cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Extracting galaxy merger timescales I: Tracking haloes with WhereWolf and spinning orbits with OrbWeaver
Creators: name: Poulton, Rhys J. J.
name: Power, Chris
name: Robotham, Aaron S. G.
name: Elahi, Pascal J.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Hierarchical models of structure formation predict that dark matter halo assembly histories are characterised by episodic mergers and interactions with other haloes. An accurate description of this process will provide insights into the dynamical evolution of haloes and the galaxies that reside in them. Using large cosmological N-body simulations, we characterise halo orbits to study the interactions between substructure haloes and their hosts, and how different evolutionary histories map to different classes of orbits. We use two new software tools - WhereWolf, which uses halo group catalogues and merger trees to ensure that haloes are tracked accurately in dense environments, and OrbWeaver, which quantifies each halo's orbital parameters. We demonstrate how WhereWolf improves the accuracy of halo merger trees, and we use OrbWeaver to quantify orbits of haloes. We assess how well analytical prescriptions for the merger timescale from the literature compare to measured merger timescales from our simulations and find that existing prescriptions perform well, provided the ratio of substructure-to-host mass is not too small. In the limit of small substructure-to-host mass ratio, we find that the prescriptions can overestimate the merger timescales substantially, such that haloes are predicted to survive well beyond the end of the simulation. This work highlights the need for a revised analytical prescription for the merger timescale that more accurately accounts for processes such as catastrophic tidal disruption.
description: 22 pages, 24 figures, accepted for publication in MNRAS
Design and construction of novel pyridine-pyrimidine hybrids as selective COX-2 suppressors: anti-inflammatory potential, ulcerogenic profile, molecular modeling and ADME/Tox studies
Creators: name: Shaker, Mohamed E.
name: Goma, Hesham A. M.
name: Alsalahat, Izzeddin
name: Elkanzi, Nadia A. A.
name: Azouz, Amany A.
name: Abdel-Bakky, Mohamed Sadek
name: Ghoneim, Mohammed M.
name: Hazem, Sara H.
name: El-Mesery, Mohamed E.
name: Farouk, Amr
name: Alzarea, Sami I.
name: Alsahli, Tariq G.
name: Alotaibi, Nasser Hadal
name: Musa, Arafa
name: Abdelgawad, Mohamed A.
name: Bakr, Rania B.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: NSAIDs represent a mainstay in pain and inflammation suppression, and their actions are mainly based on inhibiting COX-1 and COX-2 enzymes. Due to the adverse effects of these drugs, especially on the stomach and heart, scientists efforts have been directed to manufacture selective COX-2 without cardiovascular side effects and with minimal effects on the stomach. The cardiovascular side effects are thought to be related to the chemical composition rather than mechanism of action of these drugs. Novel pyridopyrimidines, 9a-j, were prepared and their chemical structures were confirmed by NMR, mass and IR Spectra, and elemental analysis. The effect of the 9a-j compounds on COX-1 and COX-2 was assessed and it was found that 2-hydrazino-5-(4-methoxyphenyl)-7-phenyl-3H-pyrido[2,3-d)pyrimidin-4-one (9d) was the most potent COX-2 inhibitor (IC50 = 0.54 uM) compared to celecoxib (IC50 = 1.11 uM) with selectivity indices of 6.56 and 5.12, respectively. The in vivo inhibition of paw edema of novel compounds 9a-j was measured using carrageenan-induced paw edema method, and that 2-hydrazino-5-(4-methoxyphenyl)-7-phenyl-3H-pyrido[2,3-d)pyrimidin-4-one (9d) showed the best inhibitory activity in comparison with the other compounds and celecoxib. The gastroprotective effect of the potent derivatives 9d, 9e, 9f, 9 g and 9h was investigated. 2-Hydrazino-5-(4-methoxyphenyl)-7-phenyl-3H-pyrido[2,3-d)pyrimidin-4-one (9d) and 7-(chlorophenyl)-hydrazino-5-(4-methoxyphenyl)-3H-pyrido[2,3-d)pyrimidin-4-one (9e) showed ulcer indices comparable to celecoxib (1 and 0.5 vs 0.5, respectively). Docking studies were carried out and they confirmed the mechanistic action of the designed compounds
Prostanoids in scleroderma microangiopathy: clinical and pharmacoeconomic comparison between two intravenous regimens
Creators: name: S Barsotti
name: V Lorenzoni
name: M Di Battista
name: A D’Ascanio
name: B Silvia
name: L Puccetti
name: G Turchetti
name: A Della Rossa
name: M Mosca
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Science Policy

description: Objectives: Intravenous iloprost (ILO) has widely demonstrated its effectiveness and safety in systemic sclerosis (SSc) patients. Unfortunately, there is no clear consent about dosage, duration, frequency, and infusion modality. The aim of this study was to compare two different therapeutic schemes in the same cohort of consecutive SSc subjects, evaluating differences in terms of effectiveness [digital ulcer (DU) outcome], safety, and direct healthcare costs. Method: This was a retrospective observational study of 47 patients classified with SSc treated with intravenous ILO for severe Raynaud’s phenomenon and/or DUs. Two regimens were compared: a continuous inpatient scheme and a daily outpatient scheme. Demographics and clinical data, concomitant therapies, adverse events, and data on resource use and costs were collected. Results: The number of DUs rose slightly with the switch from the continuous to the daily scheme (0.61 ± 1.2 vs 1.1 ± 1.7). Moreover, in the daily scheme there was an increase in the number of therapeutic cycles (2.4 ± 0.7 vs 4.71 ± 1.4, p Conclusion: Treatment with a daily scheme of ILO is characterized by worse tolerability and a higher dropout rate compared to a low-flow regimen, with similar costs. We suggest that a low-flow continuous therapeutic scheme is preferable in SSc patients.
Pseudogap Phase: Exchange Energy Driven vs. Kinetic Energy Driven
Creators: name: Gu, Zhengcheng
name: Li, Tao
name: Weng, Zheng-Yu
Publisher: name: arXiv
Year: 2004
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We show that both kinetic and superexchange energies of the t-J model may be read off from the optical data, based on an optical sum rule for the Hubbard model. Then we comparatively study two mean-field theories of pseudogap phase based on the t-J model. We find that while the pseudogap phase is superexchange-energy-driven in the slave-boson resonating-valence-bond (RVB) state, it is kinetic-energy-driven in the bosonic RVB state. The sharp contrast in the mechanisms of the pseudogap phases can be attributed to the fact that the antiferromagnetic (AF) correlations behave quite differently in two mean-field states, which in turn distinctly influence the kinetic energy of charge carriers. We elaborate this based on some detailed studies of the superexchange energy, kinetic energy, uniform spin susceptibility, equal-time spin correlations, dynamic spin susceptibility, as well as the optical conductivity. The results provide a consistent picture and understanding on two physically opposite origins of pseudogap phase. In comparison with experimental measurements, we are led to conclude that the pseudogap phase in the cuprates should be kinetic-energy-driven in nature.
description: 15 pages, 9 figures
MOESM2 of Effectiveness of remineralising agents in prevention and treatment of orthodontically induced white spot lesions: a protocol for a systematic review incorporating network meta-analysis
Creators: name: Huimin Hu
name: Feng, Chong
name: Zhaowei Jiang
name: Lufei Wang
name: Sonu Shrestha
name: Xiaoming Su
name: Shu, Yu
name: Ge, Long
name: Wenli Lai
name: Hua, Fang
name: Long, Hu
Publisher: name: figshare
Year: 2019
Subjects: subject: Biotechnology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2. MEDLINE search strategy.
A Quantum Non-demolition measurement of Fock states of mesoscopic mechanical oscillators
Creators: name: Santamore, D. H.
name: Doherty, A. C.
name: Cross, M. C.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We investigate a scheme that makes a quantum non-demolition measurement of the excitation level of a mesoscopic mechanical oscillator by utilizing the anharmonic coupling between two elastic beam bending modes. The non-linear coupling between the two modes shifts the resonant frequency of the readout oscillator proportionate to the excitation of the system oscillator. This frequency shift may be detected as a phase shift of the readout oscillation when driven on resonance. We show that in an appropriate regime this measurement approaches a quantum non-demolition measurement of the phonon number of the system oscillator. As phonon energies in micromechanical oscillators become comparable to or greater than the thermal energy, the individual phonon dynamics within each mode can be resolved. As a result it should be possible to monitor jumps between Fock states caused by the coupling of the system to the thermal reservoirs.
description: revised, 21 pages, 9 figures
Fluxos de Exportação de Soja do Estado do Mato Grosso: uma aplicação de programação linear
Creators: name: Ojima, Andrea Leda Ramos De Oliveira
name: Ojima, Andrea Leda Ramos De Oliveira
Publisher: name: Unknown
Year: 2006
Subjects: subject: Crop Production/Industries
subject: soja
subject: logística
subject: Mato Grosso.

description: A proposta deste artigo é estimar os fluxos das principais alternativas para a exportação da soja mato-grossense. As estimativas foram feitas através da aplicação de um modelo matemático baseado no instrumental associado às matrizes origem-destino e avaliou-se três cenários. Como principais resultados, o modelo indicou que as opções intermodais deveriam ser utilizadas para o escoamento da soja, em especial a rota rodo-hidroviária via Porto de Santarém que deteve 60% das exportações e seguida pela opção rodo-ferroviária via Porto de Santos com 21%. O artigo também aponta que a iniciativa de novos estudos neste sentido, podem trazer benefícios sobre a racionalização da infra-estrutura de transporte, assim como, sobre as potencialidades do setor.
Elemental evaluation, nutritional analysis, GC-MS analysis and ameliorative effects of Artocarpus communis J.R.Forst. & G.Forst. seeds’ phytoconstituents on metabolic syndrome via in silico approach
Creators: name: Ogunlakin, Akingbolabo Daniel
name: Ojo, Oluwafemi Adeleke
name: Gyebi, Gideon Ampoma
name: Akinwumi, Idayat Adeola
name: Adebodun, Great Oluwamayokun
name: Ayokunle, Damilare Iyinkristi
name: Ambali, Owoola Azeezat
name: Ayeni, Peluola Olujide
name: Awosola, Oyindamola Esther
name: Babatunde, Dare Ezekiel
name: Akintunde, Emmanuel Adewuni
name: Ajayi-Odoko, Omolola Adenike
name: Dahunsi, Olatunde Samuel
name: Sonibare, Mubo Adeola
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: The nutritional as well as beneficial effects of the Artocarpus communis seed on metabolic syndrome complications have not been studied. In this research, the aim was to investigate the nutritional composition and beneficial effects of Artocarpus communis seeds’ phytoconstituents on the p53 core, fat mass and obesity-associated (FTO) protein and cytochrome P450 CYP11A1 domains. The elements and phytochemicals in the seed were determined through atomic absorption spectroscopy assay and gas chromatography–mass spectrometry (GC-MS) analysis, respectively. Also, the compounds detected were docked to the p53 core, FTO protein and cytochrome P450 CYP11A1 domains protein. Artocarpus communis seed contains sodium (7.824 ± 0.0134 ppm), magnesium (10.187 ± 0.0239 ppm) and iron (1.924 ± 0.0017), while zinc and cadmium were undetected. Phenolics and flavonoids were the most abundant phytochemicals in the seed. Phytoconstituents, such as pentadecanoic acid, hexadecanoic acid and methyl ester, possessing different therapeutic effects were identified via GC-MS analysis. In A. communis seed, 3-methyl-4-nitro-5-(1-pyrazolyl) pyrazole and phenanthrene were able to bind more peculiarly and specifically to the p53 core, FTO protein and cytochrome P450 CYP11A1 domains. One of the important processes that were hypothesized for the recovery of metabolic syndrome in affected victims is shown by the molecular dynamics analysis, which shows that the binding of these chemicals to the targeted structure stabilized the proteins. Therefore, Artocarpus communis seeds could be a new strategy for the management of metabolic syndrome.
Tricondyla (Tricondyla) deuvei : Naviaux 2002
Creators: name: Wiesner, Jürgen
name: Bandinelli, Aligi
name: Matalin, Andrey
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Carabidae
Tricondyla
Tricondyla deuvei

description: 4.  Tricondyla (Tricondyla) deuvei  Naviaux, 2002 (Fig. 4, 201)
 Tricondyla (Tricondyla) deuvei: Naviaux 2002: 40-42.
 Published data. NORTHEAST: Lang Son (Mont Mau Son) (Naviaux 2002: 40); RED RIVER DELTA: Vinh Phuc (Tam Dao) (Naviaux 2002: 40).
 Distribution. Vietnam (Lang Son, Vinh Phuc).
description: Published as part of Wiesner, Jürgen, Bandinelli, Aligi & Matalin, Andrey, 2017, Notes on the tiger beetles (Coleoptera: Carabidae: Cicindelinae) of Vietnam. 135. Contribution towards the knowledge of Cicindelinae, pp. 1-131 in Insecta Mundi 2017 (589) on page 6, DOI: 10.5281/zenodo.5169363
Additional file 2 of Effect of collaborative quality improvement on stillbirths, neonatal mortality and newborn care practices in hospitals of Telangana and Andhra Pradesh, India: evidence from a quasi-experimental mixed-methods study
Creators: name: Zamboni, Karen
name: Samiksha Singh
name: Tyagi, Mukta
name: Zelee Hill
name: Hanson, Claudia
name: Schellenberg, Joanna
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2: Annex 2: Post-hoc before and after comparison (intervention and comparison groups combined)
Experimental characterization of modal noise in multimode fibers for astronomical spectrometers
Creators: name: Oliva, E.
name: Rainer, M.
name: Tozzi, A.
name: Sanna, N.
name: Iuzzolino, M.
name: Brucalassi, A.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Starting from our puzzling on-sky experience with the GIANO-TNG spectrometer we set up an infrared high resolution spectrometer in our laboratory and used this instrument to characterize the modal noise generated in fibers of different types (circular and octagonal) and sizes. Our experiment includes two conventional scrambling systems for fibers: a mechanical agitator and an optical double scrambler. We find that the strength of the modal noise primarily depends on how the fiber is illuminated. It dramatically increases when the fiber is under-illuminated, either in the near field or in the far field. The modal noise is similar in circular and octagonal fibers. The Fourier spectrum of the noise decreases exponentially with frequency; i.e., the modal noise is not white but favors broad spectral features. Using the optical double scrambler has no effect on modal noise. The mechanical agitator has effects that vary between different types of fibers and input illuminations. In some cases this agitator has virtually no effect. In other cases, it mitigates the modal noise, but flattens the noise spectrum in Fourier space; i.e., the mechanical agitator preferentially filters the broad spectral features. Our results show that modal noise is frustratingly insensitive to the use of octagonal fibers and optical double scramblers; i.e., the conventional systems used to improve the performances of spectrographs fed via unevenly illuminated fibers. Fiber agitation may help in some cases, but its effect has to be verified on a case-by-case basis. More generally, our results indicate that the design of the fiber link feeding a spectrograph should be coupled with laboratory measurements that reproduce, as closely as possible, the conditions expected at the telescope
description: 7 pages, 6 figures, accepted by Astronomy and Astrophysics
High-throughput virtual screening, pharmacophore modelling and antagonist effects of small molecule inhibitors against cytotoxin-induced cytotoxicity
Creators: name: Lim, En Qi
name: Ahemad, Nafees
name: Yap, Michelle Khai Khun
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer

description: Cobra venom cytotoxins (CTX) cause dermonecrosis in envenomed patients who suffered from limb amputations due to the limitation of serotherapy-based antivenoms. This study aimed to identify small molecule inhibitors against CTX. A structure-based high-throughput virtual screening (HTVS) was conducted based on a conserved CTX, using the Natural Product Activity and Species Source (NPASS) screening library. The hits were valerenic acid, 1-oxo-2H-isoquinoline-4-carboxylic acid, acenaphthene, and 5-bromopyrrole-2-carboxamide, which interacted with contemporary antivenom binding site A and functional loops I–III of CTX, respectively, in molecular docking studies. Furthermore, molecular dynamic simulations were performed along with analysis of ligand fitness through their pharmacophore and pharmacokinetics properties. The antagonist effects of these hits on CTX-induced cytotoxicity were examined in human keratinocytes (HaCaT). Despite having a low binding affinity (KD = 14.45 × 10−4 M), acenaphthene demonstrated a significant increase of cell viability at 6 h and 24 h in experimental envenomed HaCaT. It also demonstrated the highest neutralization potency against CTX with a median effective concentration (EC50) of 0.05 mL/mg. Acenaphthene interacted with the functional loop II, which is the crucial cytotoxic site of CTX. It has an aromatic ring as its primary pharmacophoric feature, commonly used for rational drug design. In conclusion, acenaphthene could be a promising lead compound as a small molecule inhibitor.
Clinical efficacy of external beam radiotherapy complementing incomplete transarterial chemoembolization for hepatocellular carcinoma
Creators: name: Sunmin Park
name: Yoon, Won Sup
name: Jang, Mi Hee
name: Rim, Chai Hong
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Cancer

description: Purpose: External beam radiotherapy (EBRT) has been commonly applied as salvage or a combination locoregional modality after transarterial chemoembolization (TACE) for hepatocellular carcinomas (HCCs). This study reports oncologic outcomes and feasibility after application of the two modalities in our center. Methods: Forty consecutive patients who underwent EBRT due to incomplete responses of TACE were evaluated. Fourteen patients (35.0%) received stereotactic body radiotherapy (SBRT) and the remaining patients received conventionally fractionated radiotherapy (RT). A majority of patients who underwent SBRT received doses of 27 to 48 Gy in 3–4 fractions (median *EQD2: 57.0 Gy). Conventionally fractionated RT was performed with a median EQD2 of 47.8 Gy. Results: The median follow-up duration was 14.4 months (range: 2.6–83.0 months). A majority (77.5%) of patients were regarded as having Child-Pugh grade A. The median tumor size was 3.4 cm (range: 0.8–20.1 cm). Ten patients (25.0%) had thrombosis at a main portal branch. The 1- and 2-year overall survival (OS) and progression-free survival (PFS) rates were 82.2% and 42.1% and 55.8% and 32.1%, respectively. The local control rates were 89.1% and 89.1% at 1 and 2 years, respectively. The albumin level was a significant factor affecting OS (p = 0.002), and the BCLC stage significantly affected PFS (p = 0.001). Intrahepatic, out-of-field recurrence was the main cause of disease progression (60.0%), and distant metastasis developed in 12 patients (30.0%) during follow-up. Non-classic radiation-induced liver disease was seen in five (12.5%) patients, and two (5%) patients experienced grade ≥3 hepatic toxicities. Conclusions: EBRT after incomplete TACE was feasible and yielded favorable oncologic outcomes. However, disease progression related to intrahepatic failure remained a hindrance. *EQD2: Equivalent dose in 2 Gy per fraction radiotherapy
MOESM1 of Effectiveness of remineralising agents in prevention and treatment of orthodontically induced white spot lesions: a protocol for a systematic review incorporating network meta-analysis
Creators: name: Huimin Hu
name: Feng, Chong
name: Zhaowei Jiang
name: Lufei Wang
name: Sonu Shrestha
name: Xiaoming Su
name: Shu, Yu
name: Ge, Long
name: Wenli Lai
name: Hua, Fang
name: Long, Hu
Publisher: name: figshare
Year: 2019
Subjects: subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Additional file 1. PRISMA-P checklist.
Additional file 3 of Effect of collaborative quality improvement on stillbirths, neonatal mortality and newborn care practices in hospitals of Telangana and Andhra Pradesh, India: evidence from a quasi-experimental mixed-methods study
Creators: name: Zamboni, Karen
name: Samiksha Singh
name: Tyagi, Mukta
name: Zelee Hill
name: Hanson, Claudia
name: Schellenberg, Joanna
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 3: Annex 3: Table 5 – Leadership, Table 6 – Contextual challenges for QI team mobilisation and capacity building, Table 7 - Perceptions of programme by health workers, Table 8 – mechanisms of change
Tricondyla (Tricondyla) gestroi subsp. scabra Fleutiaux 1920
Creators: name: Wiesner, Jürgen
name: Bandinelli, Aligi
name: Matalin, Andrey
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Carabidae
Tricondyla
Tricondyla gestroi
Tricondyla (tricondyla) gestroi scabra fleutiaux, 1920

description: 9.  Tricondyla (Tricondyla) gestroi scabra  Fleutiaux, 1920 (Fig. 9, 206)
 Tricondyla Gestroi scabra: Horn 1924: 4; 1929: 18.
 Tricondyla (Tricondyla) gestroi scabra: Naviaux 2002: 47, 48.
 Published data. NORTHEAST: Lao Cai (Sa Pa) (Horn 1924: 4; 1929: 18; Naviaux 2002: 47).
 New records. NORTHEAST: Lao Cai, Sa Pa, 1250m, leg. A. Napolov, 1-5.vii.1998, 1 female (ANLC), Lao Cai, 6 km W of Sa Pa, northern slop of Fan-Si-Pan Mountain, leg. A.V. Abramov, v.2008, 3 males (ZISP), Lao Cai, Hoang Lien Son Mountain Ridge, Fan-Si-Pan Mountain, near Tram Tong, 1950-2100m, leg. D. Fedorenko, 15-30.vii.2007, 2 males, 1 female (MPU, SIEE), Lao Cai, Hoang Lien National Park, Tram Non, N22 o 21’ 11.82” E103 o 46’ 30.78”, 1800-2050m, leg. R. Gerstmeier, 16.v.2015, 2 males, 2 females (JWGC), l. c. leg. A. Skale, 13-16.v.2015, 1 male, 10 females (ASGC).
 Distribution. Vietnam (Lao Cai), China (Xizang, Yunnan), Laos (Houaphanh, Phongsaly, Xiengkhuang), Thailand (Chiang Mai, Nahkon Ratchasima).
description: Published as part of Wiesner, Jürgen, Bandinelli, Aligi & Matalin, Andrey, 2017, Notes on the tiger beetles (Coleoptera: Carabidae: Cicindelinae) of Vietnam. 135. Contribution towards the knowledge of Cicindelinae, pp. 1-131 in Insecta Mundi 2017 (589) on page 7, DOI: 10.5281/zenodo.5169363
Synthesis, structure elucidation, SC-XRD/DFT, molecular modelling simulations and DNA binding studies of 3,5-diphenyl-4,5-dihydro-1H-pyrazole chalcones
Creators: name: Mustafa, Ghulam
name: Sabir, Sabreena
name: Sumrra, Sajjad Hussain
name: Zafar, Wardha
name: Arshad, Muhammad Nadeem
name: Hassan, Abrar Ul
name: Akhtar, Arusa
name: Ashfaq, Muhammad
name: Ashfaq, Maryam
name: Asiri, Abdullah Mohamed
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Deoxyribonucleic acid (DNA) acts as the most important intracellular target for various drugs. Exploring the DNA binding interactions of small bioactive molecules offers a structural guideline for designing new drugs with higher clinical efficacy and enhanced selectivity. This study presents the facile synthesis of pyrazoline-derived compounds (4a)-(4f) by reacting substituted chalcones with hydrazine hydrate using formic acid. The structure elucidation of substituted pyrazoline compounds was carried out using 1H-NMR, FT-IR and elemental analyses. While the crystal structures of two compounds (4a) and (4b) have been resolved by single-crystal X-ray diffraction (SC-XRD) analysis. Hirshfeld surface analysis also endorsed their greater molecular stability. Computational calculations at DFT/B3LYP/6-311++G(d,p) were executed to compare the structural properties (bond angle and bond length) and explore reactivity descriptors, frontier molecular orbitals (FMO), Mulliken atomic charges (MAC), molecular electrostatic potential (MEP) and electronic properties. All the compounds were evaluated for DNA binding interactions by UV-Vis spectrophotometric analysis. The results revealed that compounds (4a)-(4f) bind to DNA via non-covalent binding mode having binding constant values ranging from 1.22 × 103 to 6.81 × 104 M−1. The negative values of Gibbs free energy also proved the interaction of studied compounds with DNA as a spontaneous process. The findings of molecular docking simulations depicted that these studied compounds showed significant binding interactions with DNA and these results were consistent with experimental findings. Compound (4b) was concluded as the most potent compound of the series with the highest binding constant (4.95 × 104) and strongest binding affinity (-8.48 kcal/mol).
Passage of uranium through human cerebral microvascular endothelial cells: influence of time exposure in mono- and co-culture in vitro models
Creators: name: C. Gloaguen
name: A. F. Raimundo
name: C. Elie
name: A. Schmitt
name: M. Floriani
name: S. Favard
name: D. Monneret
name: F. Imbert-Bismut
name: N. Weiss
name: M. A. Deli
name: K. Tack
name: P. Lestaevel
name: M. A. Benadjaoud
name: A. Legendre
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Depleted uranium (DU) has several civilian and military applications. The effects of this emerging environmental pollutant on human health raise some concerns. Previous experimental studies have shown that uranium (U) exposure can disturb the central nervous system. A small quantity of U reaches the brain via the blood, but the effects on the blood-brain barrier (BBB) remain unclear. In the present work, two cell culture models were exposed to DU for different times to study its cytotoxicity, paracellular permeability and extracellular concentration of U. The well-known immortalized human cerebral microvascular endothelial cells, hCMEC/D3, were cultured on the filter in the first model. In the second model, human primary cells of pericytes were cultured under the filter to understand the influence of cell environment after U exposure. The results show that U is not cytotoxic to hCMEC/D3 cells or pericytes until 500 µM (1.6 Bq.L−1). In addition, acute or chronic low-dose exposure of U did not disturb permeability and was conserved in both cell culture models. However, U is able to reach the brain compartment. During the first hours of exposure, the passage of U to the abluminal compartment was significantly reduced in the presence of pericytes. Electronic microscopy studies evidenced the formation of needlelike structures, like urchin-shaped precipitates, from 1 h of exposure. Analytical microscopy confirmed the U composition of these precipitates. Interestingly, precipitated U was detected only in endothelial cells and not in pericytes. U was localized in multilamellar or multivesicular bodies along the endo-lysosomal pathway, suggesting the involvement of these traffic vesicles in U sequestration and/or elimination. We show for the first time the in vitro passage of U across a human cerebral microvascular endothelial cells, and the intracellular localization of U precipitates without any cytotoxicity or modification of paracellular permeability. The difference between the results obtained with monolayers and co-culture models with pericytes illustrates the need to use complex in vitro models in order to mimic the neurovascular unit. Further in vivo studies should be performed to better understand the passage of U across the blood-brain barrier potentially involved in behavioral consequences.
Tricondyla (Tricondyla) macrodera subsp. abruptesculpta Horn 1925
Creators: name: Wiesner, Jürgen
name: Bandinelli, Aligi
name: Matalin, Andrey
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Carabidae
Tricondyla
Tricondyla macrodera
Tricondyla (tricondyla) macrodera abruptesculpta horn, 1925

description: 7.  Tricondyla (Tricondyla) macrodera abruptesculpta  Horn, 1925 (Fig. 7, 204)
 Tricondyla (Tricondyla) macrodera abruptesculpta: Naviaux 2002: 40.
 New records. RED RIVER DELTA: Vinh Phuc, Tam Dao, M. Kalabza and Z. Kostal, leg., 6-20.v.1990, 1 female (JWGC), Vinh Phuc, Tam Dao, N21 o 27’ 52” E105 o 38’ 46”, 1200 m, hand collected, leg. M. Hauser and N. von Ellenrieder, 19-22.vi.2014, 1 female (CSCA).
 Distribution. Vietnam (Vinh Phuc), China (Anhui, Fujian, Guangdong, Guizhou, Guangxi, Hunan, Jiangxi, Sichuan, Xizang, Yunnan).
 Remarks. New state record for Vietnam and new provincial record for Vinh Phuc.
description: Published as part of Wiesner, Jürgen, Bandinelli, Aligi & Matalin, Andrey, 2017, Notes on the tiger beetles (Coleoptera: Carabidae: Cicindelinae) of Vietnam. 135. Contribution towards the knowledge of Cicindelinae, pp. 1-131 in Insecta Mundi 2017 (589) on page 6, DOI: 10.5281/zenodo.5169363
Gut microbiota response to ionizing radiation and its modulation by HDAC inhibitor TSA
Creators: name: Noopur Gupta
name: Anup Kainthola
name: Tiwari, Manisha
name: Paban K. Agrawala
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Trichostatin A (TSA) has been shown to mitigate whole body γ-radiation-induced morbidity and mortality. The current study aimed at studying the effects of TSA post-irradiation treatment on gut-microbiota, especially the translocation of the microbes from the intestine to other organs in C57 Bl/6 mice model. On 1st, 3rd 5th 7th 9th 12th and 14th days after various treatments bacteria were isolated from the intestine and nearby organs (mesenteric lymph node, spleen and liver) for further analysis. The jejunum part of all animals was processed for histological analysis. The group radiation + drug showed reduced susceptibility to radiation injury as well as microbiota related anomalies compared to the irradiated alone group. This was described by increased microflora in different parts of the GI tract in the radiation + drug group compared to the irradiated group and reduced histopathological damages in the jejunum. Also, a reduced percentage of translocated bacteria were found in different organs of radiation + drug group animals. TSA treatment post-irradiation could effectively control bacterial translocation as well as GI injury in mice.
MOESM6 of Charting the diversity of uncultured viruses of Archaea and Bacteria
Creators: name: F. Coutinho
name: R. Edwards
name: F. Rodríguez-Valera
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Additional file 6: Figure S4. Prevalence of targeted host and ecosystem sources among Level-1 GL-UVAB lineages assigned through phylogenomic reconstruction and lineage expansion by closest relative identification. A) Frequency of infected host phyla across each of the 68 identified lineages. B) Frequency of ecosystem sources from which viral sequences were obtained across each of the 68 identified lineages. For clarity, only hosts and ecosystems with prevalence within a lineage equal or above 1% are shown. Numbers in parentheses indicate the total number of genomes assigned to each lineage after the step of classification through closest relative identification.
Adiabatic invariants for the FPUT and Toda chain in the thermodynamic limit
Creators: name: Grava, T.
name: Maspero, A.
name: Mazzuca, G.
name: Ponno, A.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Mathematical Physics (math-ph)
subject: Analysis of PDEs (math.AP)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We consider the Fermi-Pasta-Ulam-Tsingou (FPUT) chain composed by $N \gg 1$ particles and periodic boundary conditions, and endow the phase space with the Gibbs measure at small temperature $β^{-1}$. Given a fixed ${1\leq m \ll N}$, we prove that the first $m$ integrals of motion of the periodic Toda chain are adiabatic invariants of FPUT (namely they are approximately constant along the Hamiltonian flow of the FPUT) for times of order $β$, for initial data in a set of large measure. We also prove that special linear combinations of the harmonic energies are adiabatic invariants of the FPUT on the same time scale, whereas they become adiabatic invariants for all times for the Toda dynamics.
description: 36 pg
Molecular insights into anti-Protozoal action of natural compounds against Cryptosporidium parvum: a molecular simulation study
Creators: name: Raish, Mohammad
name: Ahmad, Ajaz
name: Khan, Shahnawaz
name: Kalam, Mohd Abul
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine

description: The current study used the major target protein lactate dehydrogenase Cryptosporidium parvum to identify potential binders. Our approach was a comprehensive three-step screening of 2,569 natural compounds. First, we used molecular docking techniques, followed by an advanced DeepPurpose ML model for virtual screening. The final step involved meticulous re-docking and detailed interaction analysis. The known inhibitor FX11 was considered as a control that was used for comparative analysis. Our screening process led to the identification of three promising compounds: 5353794, 18475114, and 25229652. These compounds were chosen due to their exceptional ability to form hydrogen bonds and their high binding scores with the protein. Here, all three hits showed H-bonds with the functional residues (Asn122 and Thr231) of protein, while 25229652 also showed H-bond with the catalytic site residue (His177). RMSD behaviour reflected stable and consistent complex formation for all the compounds in their last 30 ns trajectories. Principal component analysis (PCA) and free energy landscape (FEL) showed a high frequency of favourable low free energy states. Using the MM/GBSA calculation, compounds 5353794 (ΔGTOTAL = −34.92 kcal/mol) and 18475114 (ΔGTOTAL = −34.66 kcal/mol) had the highest binding affinity with the protein however, 25229652 (ΔGTOTAL = −22.62 kcal/mol) had ΔGTOTAL comparable to the control FX11. These natural compounds not only show the potential for hindering C. parvum lactate dehydrogenase but also open new avenues in its drug development. Their strong binding properties and stable interactions mark them as the prime candidates for further research and experimental validation as anti-cryptosporidiosis agents.
A soft-photon theorem for the Maxwell-Lorentz system
Creators: name: Dybalski, Wojciech
name: Hoang, Duc Viet
Publisher: name: arXiv
Year: 2019
Subjects: subject: Mathematical Physics (math-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Analysis of PDEs (math.AP)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 35Q60

description: For the coupled system of classical Maxwell-Lorentz equations we show that the quantities \begin{equation*} \mathfrak{F}(\hat x, t)=\lim_{|x|\to \infty} |x|^2 F(x,t), \quad \mathcal{F}(\hat k, t)=\lim_{|k|\to 0} |k| \widehat{F}(k,t), \end{equation*} where $F$ is the Faraday tensor, $\hat{F}$ its Fourier transform in space and $\hat{x}:=\frac{x}{|x|}$, are independent of $t$. We combine this observation with the scattering theory for the Maxwell-Lorentz system due to Komech and Spohn, which gives the asymptotic decoupling of $F$ into the scattered radiation $F_{\mathrm{sc},\pm}$ and the soliton field $F_{v_{\pm\infty}}$ depending on the asymptotic velocity $v_{\pm\infty}$ of the electron at large positive (+), resp. negative (-) times. This gives a soft-photon theorem of the form \begin{equation*} \mathcal{F}_{\text{sc},+}(\hat{k}) - \mathcal{F}_{\text{sc},-}(\hat{k})= -( \mathcal{F}_{v_{+\infty}}(\hat{k})-\mathcal{F}_{v_{-\infty}}(\hat{k})), \end{equation*} and analogously for $\mathfrak{F}$, which links the low-frequency part of the scattered radiation to the change of the electron's velocity. Implications for the infrared problem in QED are discussed in the Conclusions.
description: 16 pages
The Economics of Land Degradation
Creators: name: Von Braun, Joachim
name: Gerber, Nicolas
name: Mirzabaev, Alisher
name: Nkonya, Ephraim M.
name: Von Braun, Joachim
name: Gerber, Nicolas
name: Mirzabaev, Alisher
name: Nkonya, Ephraim M.
Publisher: name: Unknown
Year: 2013
Subjects: subject: Agricultural and Food Policy
subject: Community/Rural/Urban Development
subject: Environmental Economics and Policy
subject: Food Consumption/Nutrition/Food Safety
subject: Food Security and Poverty
subject: International Development
subject: Land Economics/Use
subject: Resource /Energy Economics and Policy
subject: Economics of Land Degradation
subject: ecosystem services
subject: land degradation neutrality

description: Healthy soils are essential for sustaining economies and human livelihoods. In spite of this, the key ecosystem services provided by soils have usually been taken for granted and their true value – beyond market value – is being underrated. This pattern of undervaluation of soils is about to change in view of rapidly raising land prices, which is the result of increased shortage of land and raising output prices that drive implicit prices of land (with access to water) upward. Moreover, the value of soil related ecosystems services is being better understood and increasingly valued. It is estimated that about a quarter of global land area is degraded, affecting about 1.5 billion people in all agro-ecologies around the world. Land degradation has its highest toll on the livelihoods and well-being of the poorest households in the rural areas of developing countries. Vicious circles of poverty and land degradation, as well as transmission effects from rural poverty and food insecurity to national economies, critically hamper their development process. Despite the need for preventing and reversing land degradation, the problem has yet to be appropriately addressed. Policy action for sustainable land use is lacking, and a policy framework for action is missing. Key objectives of this Issue Paper and of a proposed related global assessment of the Economics of Land Degradation (ELD) are: first, to raise awareness about the need for and role of an assessment of the economic, social and environmental costs of land degradation; and second, to propose and illustrate a scientific framework to conduct such an assessment, based on the costs of action versus inaction against land degradation. Preliminary findings suggest that the costs of inaction are much higher than the costs of action.
On Degenerate Metrics and Electromagnetism
Creators: name: Searight, T. P.
Publisher: name: arXiv
Year: 2004
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: A theory of degenerate metrics is developed and applied to the problem of unifying gravitation with electromagnetism. The approach is similar to the Kaluza-Klein approach with a fifth dimension, however no ad hoc conditions are needed to explain why the extra dimension is not directly observable under everyday conditions. Maxwell's theory is recovered with differences only at very small length scales, and a new formula is found for the Coulomb potential that is regular everywhere.
description: The published article is available on the GRG server at http://www.wkap.nl/journal
Tumor treating fields (TTF) treatment enhances radiation-induced apoptosis in pancreatic cancer cells
Creators: name: Yunhui Jo
name: Geon Oh
name: Yongha Gi
name: Heehun Sung
name: Joo, Eun Bin
name: Lee, Suk
name: Myonggeun Yoon
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Tumor treating fields (TTF) therapy is a noninvasive method that uses alternating electric fields to treat various types of cancer. This study demonstrates the combined effect of TTF and radiotherapy (RT) in vitro on pancreatic cancer, which is known to be difficult to treat. In CFPAC-I and HPAF-II pancreatic cancer cell lines, the combined in vitro effect of TTF and RT was evaluated by measuring cell counts, markers of apoptosis, and clonogenic cell survival. The synergy effects were verified using the Valeriote and Carpentier equations. TTF and RT inhibited cancer cell growth more effectively than did monotherapy with TTF or RT. The combined treatment also enhanced apoptosis more than monotherapy, as shown by assays for cleaved poly (ADP-ribose) polymerase (PARP) and annexin V. In addition, on the survival curve, this treatment method has been shown to work synergistically. These results suggest that combined treatment with TTF and RT may be a good alternative treatment for patients with pancreatic cancer.
Strong and selective interactions of palmatine with G-rich sequences in TRF2 promoter; experimental and computational studies
Creators: name: Fazelifar, Pegah
name: Cucchiarini, Anne
name: Khoshbin, Zahra
name: Mergny, Jean-Louis
name: Noureini, Sakineh Kazemi
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Virology

description: G-rich sequences have the potential to fold into G-quadruplexes (GQs). G-quadruplexes, particularly those positioned in the regulatory regions of proto-oncogenes, have recently garnered attention in anti-cancer drug design. A thermal FRET assay was employed to conduct preliminary screening of various alkaloids, aiming to identify stronger interactions with a specific set of G-rich double-labeled oligonucleotides in both K + and Na + buffers. These oligonucleotides were derived from regions associated with Kit, Myc, Ceb, Bcl2, human telomeres, and potential G-quadruplex forming sequences found in the Nrf2 and Trf2 promoters. Palmatine generally increased the stability of different G-rich sequences into their folded GQ structures, more or less in a concentration dependent manner. The thermal stability and interaction of palmatine was further studied using transition FRET (t-FRET), CD and UV-visible spectroscopy and molecular dynamics simulation methods. Palmatine showed the strongest interaction with T RF2 in both K+ and Na+ buffers even at equimolar concentration ratio. T-FRET studies revealed that palmatine has the potential to disrupt double-strand formation by the T RF2 sequence in the presence of its complementary strand. Palmatine exhibits a stronger interaction with G-rich strand DNA, promoting its folding into G-quadruplex structures. It is noteworthy that palmatine exhibits the strongest interaction with T RF2, which is the shortest sequence among the G-rich oligonucleotides studied, featuring only one nucleotide for two of its loops. Palmatine represents a suitable structure for drug design to develop more specific ligands targeting G-quadruplexes. Whether palmatine can also affect the expression of the T RF2 gene requires further studies.
Resolving stellar populations with integral field spectroscopy
Creators: name: Roth, Martin M.
name: Weilbacher, Peter M.
name: Castro, Norberto
Publisher: name: arXiv
Year: 2019
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: High-performance instruments at large ground-based telescopes have made integral field spectroscopy (IFS) a powerful tool for the study of extended objects such as galaxies, nebulae, or even larger survey fields on the sky. Here we discuss the capabilities of IFS for the study of resolved stellar populations, using the new method of PSF-fitting crowded field IFS, analogous to the well-established technique of crowded field photometry with image sensors. We review early pioneering work with first generation integral field spectrographs, the breakthrough achieved with the MUSE instrument at the ESO Very Large Telescope, the remarkable progress accomplished with MUSE in the study of globular clusters, and first results on nearby galaxies. We discuss the synergy of integral field spectrographs at 8-10m class telescopes with future facilities such as the Extremely Large Telescope (ELT).
description: 6 pages, 3 figures, accepted for AN special issue for STARS2019/SMFNS2019