cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Farrodes bimaculatus Peters and Alayo 1971
Creators: name: L, Carlos Naranjo
name: Peters, Janice G.
name: del, Pedro López
name: Castillo
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Ephemeroptera
Leptophlebiidae
Farrodes
Farrodes bimaculatus

description: A.14. Farrodes bimaculatus Peters and Alayo, 1971
Figures 7, 40.
 Farrodes bimaculatus Peters and Alayo in Peters 1971:8 (male and female imagos); Kluge 1994:252 (nymph, egg).
 Holotype. Male imago, [Province Mayabeque], Río Güines, March 1966, P. Alayo.
 Farrodes bimaculatus was originally described from an adult from Mayabeque Province (Peters and Alayo in Peters 1971). The nymph was described by Kluge (1994) from localities in the provinces of Pinar del Río, Sancti Spíritus, Guantánamo, and Santiago de Cuba. It is most easily recognized by the large subapical denticle on the claws.
 Ecology. According to the literature, nymphs of this species prefer rocky-bottomed or muddy-rocky rivers and actively seek refuge under stones. The species is abundant at all altitudes but mostly between 100 and 750 m and especially above 500 m. In the collections are 353 specimens collected from diverse habitats from backwaters to rapids, with a preference for rapids. Nymphs have been collected throughout the year, indicating a non-seasonal life cycle.
 Geographic distribution. Based on data of Peters (1971), Kluge (1994), and the review of the collections used for this work, the species is widespread throughout the Cuban Archipelago and has been collected from all four regions of Cuba (Fig. 7).
description: Published as part of L, Carlos Naranjo, Peters, Janice G., del, Pedro López & Castillo, 2019, Ephemeroptera (Insecta) in Cuba, pp. 1-52 in Insecta Mundi 2019 (736) on page 11, DOI: 10.5281/zenodo.5170691
Bond Graph Model of Cerebral Circulation: Toward Clinically Feasible Systemic Blood Flow Simulations
Creators: name: Su, Shan
name: Blanco, Pablo J.
name: Müller, Lucas O.
name: Hunter, Peter J.
name: Safaei, Soroush
Publisher: name: Physiome
Year: 2020
Subjects: Cell Biology
Biochemistry
Computational Biology

description: The primary paper Safaei et al. (2018) proposed an anatomically detailed model of the human cerebral circulation that runs faster than real-time on a desktop computer and is designed for use in clinical settings when the speed of response is important. Based on a one-dimensional formulation of the flow of an incompressible fluid in distensible vessels, a lumped parameter model was developed for 218 arterial segments. The proposed model improved simulation speed by approximately 200-fold while preserved accuracy. Bond graph formulation was used to ensure mass and energy conservation. The model predicted the pressure and flow signatures in the body.
Structure modification and anti-tumor activity evaluation on sesquiterpene lactones TBA and TBB from Sphagneticola trilobata
Creators: name: Xiuqiao, Zhou
name: Jiling, Yi
name: Guangying, Chen
name: Zhixiang, Liu
name: Yang, Hui
name: Wenhao, Chen
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biophysics
Biochemistry
Space Science
Medicine
Cell Biology
Pharmacology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Thirteen sesquiterpene lactone derivatives were designed and synthesised using the sesquiterpene lactone epimers TBA and TBB as the parent molecules, isolated from Sphagneticola trilobata. Their structures were elucidated by extensive spectroscopic studies and chemical evidence. Furthermore, the structures of 1a, 4b and 5a were confirmed by X-ray single-crystal diffraction analyses. All of the compounds were further examined for their in vitro antiproliferative activity against human cancer cell lines HeLa and MCF-7. Unfortunately, the activity of all derivatives were weaker than that of the parental compounds.
PS1-STRM: Neural network source classification and photometric redshift catalogue for PS1 $3π$ DR1
Creators: name: Beck, Róbert
name: Szapudi, István
name: Flewelling, Heather
name: Holmberg, Conrad
name: Magnier, Eugene
Publisher: name: arXiv
Year: 2019
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The Pan-STARRS1 (PS1) $3π$ survey is a comprehensive optical imaging survey of three quarters of the sky in the $grizy$ broad-band photometric filters. We present the methodology used in assembling the source classification and photometric redshift (photo-z) catalogue for PS1 $3π$ Data Release 1, titled Pan-STARRS1 Source Types and Redshifts with Machine learning (PS1-STRM). For both main data products, we use neural network architectures, trained on a compilation of public spectroscopic measurements that has been cross-matched with PS1 sources. We quantify the parameter space coverage of our training data set, and flag extrapolation using self-organizing maps. We perform a Monte-Carlo sampling of the photometry to estimate photo-z uncertainty. The final catalogue contains $2,902,054,648$ objects. On our validation data set, for non-extrapolated sources, we achieve an overall classification accuracy of $98.1\%$ for galaxies, $97.8\%$ for stars, and $96.6\%$ for quasars. Regarding the galaxy photo-z estimation, we attain an overall bias of $\left=0.0005$, a standard deviation of $σ(Δz_{\mathrm{norm}})=0.0322$, a median absolute deviation of $\mathrm{MAD}(Δz_{\mathrm{norm}})=0.0161$, and an outlier fraction of $O=1.89\%$. The catalogue will be made available as a high-level science product via the Mikulski Archive for Space Telescopes at https://doi.org/10.17909//t9-rnk7-gr88.
description: 12 pages, 6 figures. Submitted to MNRAS
Transparency in reporting of phase 3 cancer clinical trial results
Creators: name: Roshal R. Patel
name: Verma, Vivek
name: Fuller, Clifton D.
name: McCaw, Zachary R.
name: Ludmir, Ethan B.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: Transparency in reporting of phase 3 cancer clinical trial results
AUV observations under the sea-ice around grounded icebergs (D2.2)
Creators: name: Wåhlin, Anna
Publisher: name: Zenodo
Year: 2024

description: This deliverable consists of a high resolution bathymetry data set, obtained with an AUV-mounted multibeam, in an ice-covered region near Bear Ridge in the Amundsen Sea. In total we obtained 25 km2 of high resolution (1 m grid size) bathymetry. This can be compared to the resolution normally obtained from a ship-borne multibeam, which is 10-20 m. An initial assessment of the traces seen is also provided.
In-medium vector meson masses in a Chiral SU(3) model
Creators: name: Zschiesche, D.
name: Mishra, A.
name: Schramm, S.
name: Stöcker, H.
name: Greiner, W.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: A significant drop of the vector meson masses in nuclear matter is observed in a chiral SU(3) model due to the effects of the baryon Dirac sea. This is taken into account through the summation of baryonic tadpole diagrams in the relativistic Hartree approximation. The appreciable decrease of the in-medium vector meson masses is due to the vacuum polarisation effects from the nucleon sector and is not observed in the mean field approximation.
description: 26 pages including 10 figures; the text has been modified for clarity
Deriving star cluster parameters with convolutional neural networks. II. Extinction and cluster/background classification
Creators: name: Bialopetravičius, J.
name: Narbutis, D.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Context. Convolutional neural networks (CNNs) have been established as the go-to method for fast object detection and classification on natural images. This opens the door for astrophysical parameter inference on the exponentially increasing amount of sky survey data. Until now, star cluster analysis was based on integral or resolved stellar photometry, which limits the amount of information that can be extracted from individual pixels of cluster images. Aims. We aim to create a CNN capable of inferring star cluster evolutionary, structural, and environmental parameters from multi-band images, as well to demonstrate its capabilities in discriminating genuine clusters from galactic stellar backgrounds. Methods. A CNN based on the deep residual network (ResNet) architecture was created and trained to infer cluster ages, masses, sizes, and extinctions, with respect to the degeneracies between them. Mock clusters placed on M83 Hubble Space Telescope (HST) images utilizing three photometric passbands (F336W, F438W, and F814W) were used. The CNN is also capable of predicting the likelihood of a cluster's presence in an image, as well as quantifying its visibility (signal-to-noise). Results. The CNN was tested on mock images of artificial clusters and has demonstrated reliable inference results for clusters of ages $\lesssim$100 Myr, extinctions $A_V$ between 0 and 3 mag, masses between $3\times10^3$ and $3\times10^5$ ${\rm M_\odot}$, and sizes between 0.04 and 0.4 arcsec at the distance of the M83 galaxy. Real M83 galaxy cluster parameter inference tests were performed with objects taken from previous studies and have demonstrated consistent results.
description: 17 pages, 21 figures
Trombose do Seio Cavernoso em Criança de 4 anos com Sinusite – Complicações Oculares
Creators: name: Colaço, Maria Luísa
name: Silva, Ana
name: Bráz, Filipe
name: Franco, Mónica
name: Amorim, Ricardo
name: Silva, Tiago
name: Maia Sêco, José
Publisher: name: Revista Sociedade Portuguesa de Oftalmologia
Year: 2014

description: Introdução: Descreve-se um caso de trombose séptica do seio cavernoso numa criança pela sua raridade e riqueza de semiologia oftalmológica. Material e Métodos: ♀ 4 anos, internada por otalgia direita, cefaleias, febre, vómitos e pros- tração. O exame oftalmológico revelou ausência de perceção luminosa no olho direito (OD), proptose, edema peri-orbitário, ptose, exotropia parética de OD e anisocória por midríase OD. O disco ótico direito apresentava palidez nos quadrantes temporais. Realizou punção lombar (PL), Tomografia Computorizada (TC) e Ressonância Magnética Nuclear (RMN) crânio-encefálica (CE) e orbitária. Iniciou antibioterapia, corticoterapia e anticoagulação. Resultados: A PL foi compatível com Meningite. A TC revelou sinusite etmoidal e esfenoidal direita. Realizou etmoidectomia anterior e esfenoidectomia transnasal direita com drenagem de secreções mucopurulentas. A TC e RMN CE e orbitária revelaram defeito de captação de con- traste do seio cavernoso direito e ectasia da veia oftálmica superior, a nível orbitário observou-se estiramento do nervo ótico. Conclusão: A Trombose do Seio Cavernoso está associada a mortalidade e morbilidade signi- ficativas tendo a maioria dos sobreviventes algum défice neurológico. A doente do nosso caso apresentou sequelas oculares com diminuição da acuidade visual e parésia completa do III nervo craniano. O diagnóstico e tratamento precoces são fundamentais no prognóstico destes casos.
description: Revista Sociedade Portuguesa de Oftalmologia, Vol. 37 N.º 1 (2013)
Assigning Quantum-Mechanical Initial Conditions to Cosmological Perturbations
Creators: name: Giovannini, Massimo
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Astrophysics (astro-ph)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Quantum-mechanical initial conditions for the fluctuations of the geometry can be assigned in excess of a given physical wavelength. The two-point functions of the scalar and tensor modes of the geometry will then inherit corrections depending on which Hamiltonian is minimized at the initial stage of the evolution. The energy density of the background geometry is compared with the energy-momentum pseudo-tensor of the fluctuations averaged over the initial states, minimizing each different Hamiltonian. The minimization of adiabatic Hamiltonians leads to initial states whose back-reaction on the geometry is negligible. The minimization of non-adiabatic Hamiltonians, ultimately responsible for large corrections in the two-point functions, is associated with initial states whose energetic content is of the same order as the energy density of the background.
description: 29 pages in Latex style
Realistic modeling of wind and supernovae shocks in star clusters: addressing ${\rm ^{22}Ne/^{20}Ne}$ and other problems in Galactic cosmic rays
Creators: name: Gupta, Siddhartha
name: Nath, Biman B.
name: Sharma, Prateek
name: Eichler, David
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Cosmic ray (CR) sources leave signatures in the isotopic abundances of CRs. Current models of Galactic CRs that consider supernovae (SNe) shocks as the main sites of particle acceleration cannot satisfactorily explain the higher ${\rm ^{22}Ne/^{20}Ne}$ ratio in CRs compared to the interstellar medium. Although stellar winds from massive stars have been invoked, their contribution relative to SNe ejecta has been taken as a free parameter. Here we present a theoretical calculation of the relative contributions of wind termination shocks (WTSs) and SNe shocks in superbubbles, based on the hydrodynamics of winds in clusters, the standard stellar mass function, and stellar evolution theory. We find that the contribution of WTSs towards the total CR production is at least $25\%$, which rises to $\gtrsim 50\%$ for young ($\lesssim 10$ Myr) clusters, and explains the observed $^{22}{\rm Ne}/^{20} {\rm Ne}$ ratio. We argue that since the progenitors of apparently isolated supernovae remnants (SNRs) are born in massive star clusters, both WTS and SNe shocks can be integrated into a combined scenario of CRs being accelerated in massive clusters. This scenario is consistent with the observed ratio of SNRs to $γ$-ray bright ($L_γ\gtrsim 10^{35}$ erg s$^{-1}$) star clusters, as predicted by star cluster mass function. Moreover, WTSs can accelerate CRs to PeV energies, and solve other longstanding problems of the standard supernova paradigm of CR acceleration.
description: 19 pages, 18 figures, 1 table; Submitted to MNRAS; Comments welcome!
Coriorretinite Multifocal Periférica: Desafio Diagnóstico
Creators: name: Beselga, D.
name: Castro, M.
name: Proença, R.
name: Sousa, JPC
name: Carvalheira, F.
name: Mendes, S.
name: Neves, A.
name: Campos, J.
name: Castanheira, D.
Publisher: name: Revista Sociedade Portuguesa de Oftalmologia
Year: 2014

description: Objectivo: Apresentar o desafio do diagnóstico e da decisão terapêutica num caso de coriorreti- nite multifocal periférica (CMP) num olho único de um doente jovem, com história de trauma- tismo e cirurgia ocular no olho adelfo. Métodos: Estudo descritivo de um caso clínico com base na recolha de informação do processo clínico, observação do doente e análise de exames complementares de diagnóstico. Resultados: Doente do sexo masculino, de raça caucasiana, com 18 anos, que recorreu ao Ser- viço de Urgência por miodesópsias do olho direito, com uma semana de evolução. Apresentava uma acuidade visual de 10/10, precipitados queráticos granulomatosos e múltiplos focos perifé- ricos de coriorretinite, com vitrite e edema da papila. O olho esquerdo apresentava amaurose e desorganização estrutural, consequentes a traumatismo ocular ocorrido 6 anos antes. O estudo sistémico revelou apenas uma elevação dos níveis séricos da enzima conversora da angiotensina. As hipóteses diagnósticas colocadas foram a sarcoidose ocular e a oftalmia simpática. Com a utilização da terapêutica combinada (corticosteróides e ciclosporina A) obteve-se uma remissão completa da inflamação ocular. Após 6 meses, foi iniciada a suspensão gradual dos corticosteróides verificando-se uma recaída da inflamação intraocular. Foi tentada a suspensão da ciclosporina A, não se tendo registado recaídas, mesmo após a sua suspensão. Discussão: A evolução favorável à terapêutica combinada e o reaparecimento da uveíte anterior quando se tentou a suspensão dos corticosteróides mas não da ciclosporina A são dados a favor do diagnóstico de sarcoidose. Deste modo, não existindo critérios de diagnósticos de uma pro- vável sarcoidose, conclui-se que a resposta à terapêutica pode constituir, por si mesmo, um dado importante no diagnóstico de provável sarcoidose ocular.
description: Revista Sociedade Portuguesa de Oftalmologia, Vol. 37 N.º 1 (2013)
Hagenulus caligatus Eaton 1882
Creators: name: L, Carlos Naranjo
name: Peters, Janice G.
name: del, Pedro López
name: Castillo
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Ephemeroptera
Leptophlebiidae
Hagenulus
Hagenulus caligatus

description: A.15. Hagenulus caligatus Eaton, 1882
Figures 8, 43.
 Hagenulus caligatus Eaton 1882:207 (male subimago), 1884:113; Morrison 1919:144 (nymph); Peters 1971:20; Kluge 1994:259 (egg).
 Holotype. Male subimago, “ Rangel Mountains, Cuba (Poëy, Chas Wright and Gundlach).
 Hagenulus caligatus was described by Eaton (1882) from a male subimago, and the nymph was later illustrated by Morrison (1919). Hagenulus nymphs are recognized by their filter-feeding maxillae and forelegs. The nymphs of Hagenulus caligatus can be separated from those of H. morrisonae by a very broad labrum which exceeds the width of the head.
 Ecology. Nymphs of this species are abundant (Alayo 1977). They live in clean rivers and fast flowing rocky streams where they are found attached to the surface of the rocks, sometimes in large numbers (Alayo in Peters 1971; Alayo 1977). Alayo (in Peters 1971) found imagos and subimagos in the early morning resting on branches near the water about 2−3 m above the ground. Subimagos molted to imagos in approximately 24 hours.
 Geographic distribution. Peters (1971) and Kluge (1994) report that this species is found only in the Western region (Fig. 8). Aldana and Fonseca (2001) also reported the species from the Nipe-Sagua-Baracoa Massif, but after reexamination by the senior author the record must be considered a misidentification.
description: Published as part of L, Carlos Naranjo, Peters, Janice G., del, Pedro López & Castillo, 2019, Ephemeroptera (Insecta) in Cuba, pp. 1-52 in Insecta Mundi 2019 (736) on pages 11-12, DOI: 10.5281/zenodo.5170691
Theory of pseudogaps in charge density waves in application to photo electron or tunneling spectroscopy
Creators: name: Matveenko, S. I.
name: Brazovskii, S.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: For a one-dimensional electron-phonon system we consider the photon absorption involving electronic excitations within the pseudogap energy range. In the framework of the adiabatic approximation for the electron - phonon interactions these processes are described by nonlinear configurations of an instanton type. We calculate the subgap absorption as it can be observed by means of photo electron or tunneling spectroscopies. In details we consider systems with gapless modes: 1D semiconductors with acoustic phonons and incommensurate charge density waves. We find that below the free particle edge the pseudogap starts with the exponential decrease of transition rates changing to a power law deeply within the pseudogap, near the absolute edge.
description: International Workshop on Electronic Crystals, September 2002
MOESM1 of Sub-national levels and trends in contraceptive prevalence, unmet need, and demand for family planning in Nigeria with survey uncertainty
Creators: name: Mercer, Laina
name: Lu, Fred
name: Proctor, Joshua
Publisher: name: figshare
Year: 2019
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Computational Biology

description: Additional file 1 Supplementary materials.
Size, Productivity and Exit Decisions in Dairy Farms
Creators: name: Dong, Fengxia
name: Hennessy, David A.
name: Jensen, Helen H.
name: Dong, Fengxia
name: Hennessy, David A.
name: Jensen, Helen H.
Publisher: name: Unknown
Year: 2013
Subjects: subject: Agribusiness
subject: Farm Management
subject: dairy farms
subject: herd size
subject: productivity
subject: exit decision

description: The U.S. dairy industry has seen major restructuring in the last few decades. The number of U.S. dairy farms has declined significantly and the decline has been concentrated among smaller farms. In the meantime, average dairy herd size increased from 19 cows in 1970 to 175 in 2010 and milk yield per cow doubled over the same period. Herd size, exit and technical efficiency are related in varied ways. Many farm-level production structures are cheaper to build in large scale while asset use can be more efficient on larger facilities. Economies of scale motivate a link between larger herd size and levels of profitability that would support continued production. Technical efficiency should also affect the intention to continue production and expand scale as the more productive are better motivated and likely better positioned to continue operation and increase in size. These incentives have not been explored for dairy production. The three decisions are likely interrelated and should be investigated in an integrated, systemic manner that accounts for endogeneity. Employing data from the USDA’s 2010 ARMS Phase III, Dairy Production Practices and Costs and Returns Report, we first estimate technical efficiency using Stochastic Production Frontier analysis. The efficiency estimate is then incorporated into a system of equations that includes the exit decision and herd size. The results suggest that smaller and less efficient farms are more likely to exit and more efficient dairy farms tend to expand, results which do seem consistent with theoretical considerations and with current trends in dairy structural change.
Effect of breathing motion on robustness of proton therapy plans for left-sided breast cancer patients with indication for locoregional irradiation
Creators: name: L. Klaassen
name: A. L. Petoukhova
name: S. J. M. Habraken
name: J. Jacobs
name: M. G. A. Sattler
name: K. Verhoeven
name: Y. L. B. Klaver
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: To investigate the dosimetric impact of breathing motion on robustly optimized proton therapy treatment plans for left-sided breast cancer patients with an indication for locoregional irradiation. Clinical Target Volumes (CTVs) (left-sided breast, level 1 to 4 axillary lymph nodes, interpectoral and internal mammary lymph node regions) and organs at risk were delineated on 4 D-CTs of ten female patients. After treatment planning to a prescribed dose of 40.05 Gy(RBE) in 15 fractions on the time-averaged CT, the dose was calculated on all ten phases of the breathing cycle. Robustness to setup (5 mm) and range errors (3%) was evaluated for those ten phases. Correlations were evaluated between the phases of the breathing cycle and the D98% of the CTV and the Dmean of the heart. Correlations coefficients were between −0.12 and 0.29. At the most extreme values of the 28 robustness scenarios, the clinical goals were met for all but two patients. The mean heart dose was 0.41 Gy(RBE) with a standard deviation of 0.31 Gy(RBE) of proton therapy plans. The effect of breathing motion on the robustness of proton therapy treatment plans for this patient group is minor and not of clinical significance. Based on this patient group, a deep-inspiration breath hold seems to be unnecessary to improve robustness for these patients.
Heterogeneous behavior, obesity and storability in soft drink consumption: A dynamic demand model
Creators: name: Colantuoni, Francesca
name: Rojas, Christian
name: Colantuoni, Francesca
name: Rojas, Christian
Publisher: name: Unknown
Year: 2013
Subjects: Consumer/Household Economics
Food Consumption/Nutrition/Food Safety
Institutional and Behavioral Economics
Research Methods/ Statistical Methods

description: In this paper we applied a dynamic estimation procedure to inves- tigate the role of obesity on the demand for soda. The dynamic model accounts for storing behaviors, and allowed us to study price sensitiv- ity as well as sale sensitivity of soda consumers. By matching store level data to obesity data, we considered the effect of obesity rates on soda demand. We found that higher obesity rates were associated with a higher attitude to anticipate future needs and respond to sale prices. Conversely, according to our results, a higher rate of obesity was also associated to lower price sensitivity. We also considered how some obesity predictors affected the demand for soda. Our results contribute to the existing literature by raising important elements to help establish correct policies to fight obesity. For instance, our re- search suggests that a policy intervention restricting the magnitude of sales would be more successful than a tax increase in modifying the behavior of obese consumers.
Melanoma da Conjuntiva - Relato de Um Caso de Excepção
Creators: name: Nunes, Ana Teresa
name: Almeida, Leonor
name: Crujo, Conceição
name: Monteiro Grillo, Manuel
Publisher: name: Revista Sociedade Portuguesa de Oftalmologia
Year: 2014

description: Introdução: O Melanoma Conjuntival é uma neoplasia relativamente rara associada a uma ele- vada morbi-mortalidade. Pode surgir a partir de áreas não pigmentadas (10% dos casos aproxi- madamente), de um nevus pré-existente (aproximadamente 20% dos casos), ou a partir de uma lesão plana, pigmentada (melanose primária adquirida) com atipia (60-70% dos casos). Objectivo: Os autores descrevem um caso raro de Melanoma da Conjuntiva, numa jovem de raça negra, resultante de um nevus de longa evolução. Métodos: O método utilizado foi o de apresentação de um caso clínico. Resultados: Após excisão local e crioterapia adjuvante, até ao momento não houve sinal de recidiva. Conclusão: O Melanoma Conjuntival é uma condição grave devido à sua raridade e potenciali- dade letal. O progressivo avanço no melhoramento e conhecimento da sua história natural, bem como do tratamento têm reduzido de forma notória a sua mortalidade e morbilidade. Concluímos que existem casos de Melanoma da conjuntiva que podem ser tratados pela excisão local e crio- terapia, sem recorrer a métodos mais agressivos. Um aspecto importante neste caso raro é a relevância da análise histológica da lesão excisada, que deve ser uma metodologia a incluir em lesões pigmentadas da conjuntiva com sinais de suspeita.
description: Revista Sociedade Portuguesa de Oftalmologia, Vol. 37 N.º 1 (2013)
Overexpression of human-derived DNMT3A induced intergenerational inheritance of DNA methylation and gene expression variations in rat brain and testis
Creators: name: Li, Zhenhua
name: Ma, Yuanwu
name: Wang, Guishuan
name: Wang, Hanshu
name: Dai, Yubing
name: Zhu, Yu
name: Chen, Shitao
name: Zheng, Xiaoguo
name: Sun, Fei
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: In mammals, DNA methylation patterns are established by various types of DNA methyltransferases and can be stably passed on during cell division, thus creating a paradigm for epigenetic regulation that can mediate long-lasting changes in gene expression even when the initial triggering signal has disappeared. Although functional deficiency of DNMT3A, one of the methyltransferases, leads to abnormal DNA methylation patterns that result in developmental deficits in mammals, the impacts of its overexpression on tissue gene expression and DNA methylation patterns remain unclear. Here, our previously established hDNMT3A transgenic rat model and mRNA sequencing and bisulphite sequencing PCR were used to analyse the impact of hDNMT3A overexpression on tissue transcriptome and methylome, and whether the impact could be inherited intergenerationally was subsequently investigated. Our results revealed that the overexpression of hDNMT3A could induce notable gene expression variations in rat testis and brain. More importantly, 36.02% and 38.89% of these variations could be intergenerationally inherited to offspring without the transmission of the initial endogenic trigger in the brain and testis, respectively. Furthermore, we found that intergenerationally inherited DNA methylation variations in their promoters and exons could be the underlying mechanism. Compared with inheritable variations that were passively induced by environmental factors, these variations were actively induced by endogenous epigenetic modifiers. This study provided evidence for the epigenetic inheritance of endogenous factors that actively induce gene expression and DNA methylation variations; however, more studies are needed to determine the number of generations that these variations can be stably inherited.
Ultrasensitive nanoelectromechanical mass detection
Creators: name: Ekinci, K. L.
name: Huang, X. M. H.
name: Roukes, M. L.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: We describe the application of nanoelectromechanical systems (NEMS) to ultrasensitive mass detection. In these experiments, a modulated flux of atoms was adsorbed upon the surface of a 32.8 MHz NEMS resonator within an ultrahigh vacuum environment. The mass-induced resonance frequency shifts by these adsorbates were then measured to ascertain a mass sensitivity of 2.53x10^-18 g. In these initial measurements, this sensitivity is limited by the noise in the NEMS displacement transducer; the ultimate, limits of the technique are set by fundamental phase noise processes. Our results and analysis indicate that mass sensing of individual molecules will be realizable with optimized NEMS devices.
description: Submitted to Appl. Phys. Lett. on December 22, 2003
Oclusão Venosa Central Retiniana e Trombofilias - A Propósito de Um Caso Clínico
Creators: name: Melo Cardoso, A.
name: Cardoso, J.
name: Cunha, V.
name: Machado, I.
name: Telles, P.
name: Pereira, M.
name: Campos, N.
Publisher: name: Revista Sociedade Portuguesa de Oftalmologia
Year: 2014

description: Introdução: A incidência da oclusão venosa central de retina (OVCR) varia de 2 a 8 por 1,000 e aumenta com a idade. Os factores de risco cardiovasculares, algumas trombofilias e síndromes de hiperviscosidade podem facilitar o aparecimento da OVCR. A mutação do gene da protrom- bina (G20210A) aumenta os níveis de protrombina plasmática em 30%, elevando assim o risco de trombose venosa. Não existe, no entanto, nenhum estudo científico que mostre a associação entre OVCR e esta mutação. Caso clinico: Homem de 21 anos com diminuição súbita da acuidade visual do OD, sem ante- cedentes patológicos conhecidos. Ao exame objectivo apresentava uma AV corrigida OD 0,12 e AV OE 1,0, pressão intra-ocular OD de 30mmHg e OE de 34 mmHg. A fundoscopia demonstrou edema da papila, ingurgitamento venoso temporal e nasal e hemorragias superficiais no OD. Realizou estudo imagiológico crâneo-encefálico e das órbitas, bem como analítico e genético. Detectou-se heterozigotia para a variante da protrombina 20210A. Iniciou terapêutica dirigida para a hipertensão ocular e anti-agregação plaquetária, e fez também uma injecção intra-vítrea única de Bevacizumab 1,25mg por apresentar apresentar edema macular. A evolução foi favo- rável com AV ODE=1,0. Conclusão: Apesar da associação entre a mutação do gene da protrombina e oclusão venosa da retina não estar bem esclarecida, os portadores desta mutação têm um risco aumentado de trom- bose venosa. A OVCR tem uma origem multifactorial, neste caso a hipertensão ocular poderá ser o principal factor de risco, no entanto a descoberta desta mutação é um factor que poderá elevar ainda mais este risco num doente jovem.
description: Revista Sociedade Portuguesa de Oftalmologia, Vol. 37 N.º 1 (2013)
Bargaining power and efficiency in principal-agent relationships
Creators: name: Chambers, Robert G.
name: Quiggin, John
name: Chambers, Robert G.
name: Quiggin, John
Publisher: name: Unknown
Year: 2003
Subjects: subject: Consumer/Household Economics
subject: Demand and Price Analysis
subject: Financial Economics
subject: Bargaining power
subject: efficiency
subject: principal-agent

description: Insurance contracts are frequently modelled as principal--agent relationships. Although it is commonly assumed that the principal, in this case the insurer, has complete freedom to design the contract, the problem formulation in much of the principal--agent literature presumes that the contract is constrained-Pareto-efficient. In the present paper, we consider the implications of a richer specification of the choices available to clients. In particular, we consider the entire spectrum of possible power differentials in the contracting relationship between insurers and clients. Our central result is that the agent can exploit information asymmetries to offset the bargaining power of the insurer, but that this process is socially costly.
The role of the $Δ$(1232) on the longitudinal response in the inclusive electron scattering reaction
Creators: name: Bauer, E.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We have performed a many-body calculation of the longitudinal nuclear $(e,e')$ reaction employing a Second RPA (SRPA) formalism which contains the $Δ$(1232). More explicitly, our scheme contains RPA correlations as well as Hartree-Fock and second order self-energies, where an accurate evaluation of exchange terms is achieved. Using this formalism we have evaluated the longitudinal response function for $^{40}Ca$. We give final results at momentum transfers ranging from 300 up to 500 MeV/c, obtaining a good agreement with data.
description: 27 pages, 5 figures
MOESM1 of ddRAD sequencing-based identification of inter-genepool SNPs and association analysis in Brassica juncea
Creators: name: Jebi Sudan
name: Singh, Ravinder
name: Susheel Sharma
name: Salgotra, Romesh
name: Varun Sharma
name: Gurvinder Singh
name: Sharma, Indu
name: Swarkar Sharma
name: Gupta, Surinder
name: Sajad Zargar
Publisher: name: figshare
Year: 2019
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology

description: Additional file 1: Figure S1. Workflow design for SNPs/Variants detection in CLC Genomics Workbench (Red solid lines indicate input file; blue dotted lines indicate output file). Figure S2. Bioanalyser analysis of the prepared library (Blue peaks indicate ladder peaks and red peaks at 35 and 10,380â€‰bp indicate internal standards). Table S3. Summary of ddRAD-sequence data for six genotypes. Table S4. Details of Brassica juncea genotypes used for association analysis.
Miopia Aguda Induzida pelo Topiramato – Caso Clínico
Creators: name: Rocha, Tânia
name: Mendes Carvalho, António
name: Neves, Mário
name: Silva, João Filipe
name: Roque Loureiro, António
Publisher: name: Revista Sociedade Portuguesa de Oftalmologia
Year: 2014

description: Introdução: O Topiramato é um medicamento anticonvulsivante usado regularmente pela neu- rologia e pela psiquiatria. A miopia aguda e o glaucoma de ângulo fechado são efeitos secundá- rios que, apesar de raros, podem surgir com o uso deste medicamento. Caso Clínico: Os autores descrevem um caso clínico de miopia aguda induzida pelo topiramato. Apresentam-se os resultados dos exames complementares realizados, assim como a evolução clínica. Discussão: O mecanismo de acção pelo qual o topiramato induz miopia ainda não é totalmente conhecido. Apesar de alarmante, o quadro clinico é transitório e reverte 3 a 7 dias após a suspen- são do medicamento.
description: Revista Sociedade Portuguesa de Oftalmologia, Vol. 37 N.º 1 (2013)
Hagenulus morrisonae Peters and Alayo 1971
Creators: name: L, Carlos Naranjo
name: Peters, Janice G.
name: del, Pedro López
name: Castillo
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Ephemeroptera
Leptophlebiidae
Hagenulus
Hagenulus morrisonae

description: A.16. Hagenulus morrisonae Peters and Alayo, 1971
Figures 8, 44.
 Hagenulus morrisonae Peters and Alayo in Peters 1971:21 (male and female imagos, nymph); Kluge 1994:260.
 Holotype. Male imago, [Province Santiago de Cuba], Río Boniatico (San Luis), November 1964, P. Alayo.
 This species was described by Peters and Alayo (in Peters 1971) from Santiago de Cuba Province and other localities in the Eastern and Central region. It is easily distinguished from H. caligatus by the width of the labrum which, although broad, is narrower than the width of the head.
 Ecology. Nymphs prefer stony rivers and streams with little current and clean water and are usually found at a depth of 15−30 cm (Peters 1971). Alayo (in Peters 1971) found the subimagos throughout the day and found imagos in the evening (1700 to 1800 h) flying near the surface of the water in stony areas, the number of individuals increasing as it became darker.
 Nymphs of H. morrisonae show a clear preference for a riffle microhabitat (in one survey, 2035 individuals in riffles and 58 individuals in a lentic habitats). Aldana and Fonseca (2001) confirmed that the species prefers clear, cold, running waters at altitudes between 250 and 650 m; there, nymphs were found under stones at depths of 30−90 cm. Nymphs in collections are very abundant from lowland areas, with most (527) found in the Río Cautillo basin below 200 m (Rodríguez and Pérez 1998); numbers of individuals decrease as the altitude increases. Naranjo (1986) studied six rivers in the Sierra Maestra and found the species below 600 m; in other collection records, the species has been found up to 1750 m, but the majority of specimens are recorded below 500 m. Based on the presence of mature nymphs in the collections and their respective dates, there is no seasonal trend as they were collected in every month of the year.
 Geographic distribution. The species is very abundant (Fig. 8) and has been cited from the Central, Central-East and Eastern Regions in the Cuban archipelago (Peters 1971, Kluge 1994, Naranjo and Cañizares 1999). One population from Nipe-Sagua-Baracoa Massif has been confused with H. caligatus because of its broader labrum (Fig. 44c).
description: Published as part of L, Carlos Naranjo, Peters, Janice G., del, Pedro López & Castillo, 2019, Ephemeroptera (Insecta) in Cuba, pp. 1-52 in Insecta Mundi 2019 (736) on page 12, DOI: 10.5281/zenodo.5170691
Orbitopatia Tiroideia: Diferentes Formas de Apresentação, Diferentes Abordagens Terapêuticas
Creators: name: Pina, Susana
name: Azevedo, Ana Rita
name: Pedrosa, Catarina
name: Santos, Cristina
name: Silva, Filipe
name: Santos, Maria João
name: Ferreira, Mara
name: Cabral, João
Publisher: name: Revista Sociedade Portuguesa de Oftalmologia
Year: 2014

description: Introdução: A orbitopatia tiroideia é uma patologia inflamatória orbitária, de carácter autoi- mune e que geralmente se associa a alterações endócrinas sistémicas por disfunção da glândula tiroideia. Esta patologia pode apresentar-se em diferentes estadios: numa fase activa ou inflama- tória, ou numa fase inactiva ou fibrótica, condicionando manifestações clínicas que podem ser muito variáveis. Material e Métodos: Apresenta-se uma série de cinco casos clínicos que pretendem ilustrar diferentes formas possíveis de apresentação da doença e a respectiva abordagem terapêutica. Resultados: Nos casos apresentados assistiu-se a uma melhoria sintomática, estética e funcional. Conclusão: Na orbitopatia tiroideia o tratamento deverá ser orientado de acordo com a fase da doença. Na fase activa o tratamento é sobretudo direccionado para o controlo da inflamação. Na fase cicatricial torna-se possível actuar ao nível do dismorfismo causado pela doença com recurso a diversas técnicas cirúrgicas. O diagnóstico precoce é essencial para um tratamento adequado e atempado, podendo evitar as graves consequências físicas e psicológicas que podem advir desta patologia.
description: Revista Sociedade Portuguesa de Oftalmologia, Vol. 37 N.º 1 (2013)
Labour market and employment sources in rural areas of Bulgaria
Creators: name: Ivanov, Bozhidar
name: Popov, Rumen
name: Ivanov, Bozhidar
name: Popov, Rumen
Publisher: name: Unknown
Year: 2011
Subjects: subject: Community/Rural/Urban Development
subject: International Development
subject: Labor and Human Capital
subject: Political Economy
subject: Public Economics
subject: rural areas
subject: labour market
subject: employment
subject: unemployment rate
subject: rural-urban relations
subject: drivers
subject: socio-economic situation
subject: sources of employment
subject: strategies of orientation

description: The theory of path dependency reveals that in the territories, where the population is characterized with worsened structure, the infrastructure is affected by underdeveloped problems and the amenities are not enough evinced, it is difficult to expect designation of activities, creating new employment. The appearance of innovative and knowledge basedjob in the rural areas is very hard challenge because the prepositions providing and creating them are missing. The lack of appropriate infrastructure, the demographic problems and the affected pattern of working force in the rural areas in terms of education, qualification and abilities deprive the reliance on the endogenous resources to create new employment directions. It is found that significant resources for successful development of the rural parts are available in the realm of natural and cultural capital. The main challenge is to make a mechanism, which will utilize the natural and cultural capital of the rural areas, hence will mobilize local people and will create a new and more jobs. This is the only way to shape regional identity, bring a change in the life of people from these areas, and form stabile balance between urban and rural poles.
Simulated daily plan adaptation for magnetic resonance-guided liver stereotactic body radiotherapy
Creators: name: Taylor, Edward
name: Lukovic, Jelena
name: Velec, Michael
name: Shessel, Andrea
name: Stanescu, Teodor
name: Dawson, Laura
name: Létourneau, Daniel
name: Lindsay, Patricia
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: Liver cancers are challenging to treat using image-guided radiotherapy (IGRT) due to motion and deformation of target volumes and organs at risk (OARs), as well as difficulties in visualising liver tumours using cone-beam computed tomography (CBCT) based IGRT. Liver cancer patients may thus benefit from magnetic resonance (MR)-guided daily adaptive re-planning. We evaluated the dosimetric impact of a daily plan adaptation strategy based on daily MR imaging versus CBCT-based IGRT. Ten patients were studied who were treated with CBCT-guided five-fraction stereotactic body radiotherapy (SBRT) and underwent MR imaging before each fraction. Simulated reference plans were created on computer tomography (CT) images and adapted plans were created on the daily MR images. Two plan adaptation strategies were retrospectively simulated: (1) translational couch shifts to match liver, mimicking standard CBCT guidance and (2) daily plan adaptation based on reference plan clinical goals and daily target and OAR contours. Dose statistics were calculated for both strategies and compared. Couch shifts resulted in an average reduction in GTV D99% relative to reference plan values of 5.2 Gy (−12.5% of reference values). Daily plan adaptation reduced this to 0.8 Gy (−2.0%). For six patients who were OAR dose-limited on reference plans, couch shifts resulted in OAR dose violations in 28 out of 28 simulated fractions, respectively; no violations occurred using daily plan adaptation. No OAR dose violations occurred using either strategy for the four cases not OAR dose-limited at reference planning. MR-guided daily plan adaptation ensured OAR dose constraints were met at all simulated treatment fractions while CBCT-based IGRT resulted in a systematic over-dosing of OARs in patients whose doses were limited by OAR dose at the time of reference planning.