cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Lyman Alpha Forest in the Spectra of QSOs
Creators: name: Rauch, Michael
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Observations of redshifted Lyman alpha forest absorption in the spectra of quasistellar objects (QSOs) provide a highly sensitive probe of the distribution of gaseous matter in the universe. Over the past two decades optical spectroscopy with large ground-based telescopes, and more recently ultraviolet spectroscopy from space have yielded a wealth of information on what appears to be a gaseous, photoionized intergalactic medium, partly enriched by the products of stellar nucleosynthesis, residing in coherent structures over many hundreds of kiloparsecs. Recent progress with cosmological hydro-simulations based on hierarchical structure formation models has led to important insights into the physical structures giving rise to the forest. If these ideas are correct, a truely inter- and proto-galactic medium [at high redshift (z ~ 3), the main repository of baryons] collapses under the influence of dark matter gravity into flattened or filamentary structures, which are seen in absorption against background QSOs. With decreasing redshift, galaxies forming in the denser regions, may contribute an increasing part of the Lyman alpha absorption cross-section. Comparisons between large data samples from the new generation of telescopes and artificial Lyman alpha forest spectra from cosmological simulations promise to become a useful cosmological tool.
description: latex plus three postscript figures, uses psfig,sty; Annual Review of Astronomy and Astrophysics 1998, vol. 36 (in press)
Additional file 2 of SCR-6852, an oral and highly brain-penetrating estrogen receptor degrader (SERD), effectively shrinks tumors both in intracranial and subcutaneous ER + breast cancer models
Creators: name: Zhou, Feng
name: Yang, Guimei
name: Xue, Liting
name: Liu, Yajing
name: Guo, Yao
name: Zhu, Ji
name: Yuan, Linlin
name: Gu, Peng
name: Tang, Feng
name: Shan, Jinwen
name: Tang, Renhong
Publisher: name: figshare
Year: 2023
Subjects: Biochemistry
Cell Biology
Molecular Biology
Pharmacology
Biological Sciences not elsewhere classified
Cancer

description: Additional file 2: Target selectivity and transcription raw data.
App creation in schools for different curricula subjects - lesson learned
Creators: name: Spieler, Bernadette
name: Schindler, Christian
name: Slany, Wolfgang
name: Mashkina, Olena
Publisher: name: arXiv
Year: 2018
Subjects: subject: Computers and Society (cs.CY)
subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: The next generation of jobs will be characterized by an increased demand for people with computational and problem solving skills. In Austria, computer science topics are underrepresented in school curricula hence teaching time for these topics is limited. From primary through secondary school, only a few opportunities exist for young students to explore programming. Furthermore, today's teachers are rarely trained in computer science, which impairs their potential to motivate students in these courses. Within the "No One Left Behind" (NOLB) project, teachers were supported to guide and assist their students in their learning processes by constructing ideas through game making. Thus, students created games that referred to different subject areas by using the programming tool Pocket Code, an app developed at Graz University of Technology (TU-Graz). This tool helps students to take control of their own education, becoming more engaged, interested, and empowered as a result. To ensure an optimal integration of the app in diverse subjects the different backgrounds (technical and non-technical) of teachers must be considered as well. First, teachers were supported to use Pocket Code in the different subjects in school within the feasibility study of the project. Observed challenges and difficulties using the app have been gathered. Second, we conducted interviews with teachers and students to underpin our onsite observations. As a result, it was possible to validate Pocket Codes' potential to be used in a diverse range of subjects. Third, we focused especially on those teachers who were not technically trained to provide them with a framework for Pocket Code units, e.g., with the help of structured lesson plans and predefined templates.
description: 10 pages, 5 tables EduLearn 2017
Royena hirsuta Linnaeus, 1753, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1753
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Ericales
Ebenaceae
Royena
Royena hirsuta

description: Royena hirsuta, spec. nov.
 3. Royena foliis lanceolatis hirsutis. Roy. lugdb. 441.
 Arbutus foliis lanceolatis integerrimis hirsutis. Hort. cliff. 163.
 Staphylodendrum africanum, folio lanuginoso rosmarini latiore. Boerh. lugdb.2. p.235.
 Habitat ad Cap. b. Spei . ♄
description: Published as part of Linnaeus, Carolus, 1753, Species plantarum: exhibentes plantas rite cognitas, ad genera relatas, cum differentiis specificis, nominibus trivialibus, synonymis selectis, locis natalibus, secundum systema sexuale digestas, Stockholm :Laurentius Salvius on page 397, DOI: 10.5281/zenodo.3931989
Reminiscences of William Ambrose Prendergast, 1951
Publisher: name: Columbia University
Year: 2021
Subjects: Municipal officials and employees
Bankers
Municipal finance
Municipal government

description: Childhood on the East Side, New York City; business and finance; National Association of Credit Men, 1899-1905; national bankruptcy act, 1906; interest in politics, lecturing; New York City finances; the Office of Comptroller, 1909; New York State and City politics; Board of Estimate and Apportionment; Gaynor Charter; Progressive Party; 1912 Republican National Convention; new subway system, 1913; Mayor William Gaynor and New York City finances; Municipal Reference Library; New York State Constitutional Convention, 1915; Gary plan, 1915; legislative investigations, World War I, 1915-16; West Side improvement plan; "land deals," 1917; retrospections; impressions of prominent New Yorkers, including Theodore Roosevelt, Bainbridge Colby, Herbert Parsons, Henry L. Stimson
CLUSTERING AND LARGE SCALE STRUCTURE WITH THE SDSS
Creators: name: Bahcall, Neta A.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The Sloan Digital Sky Survey (SDSS) will provide a complete imaging and spectroscopic survey of the high-latitude northern sky. The 2D survey will image the sky in five colors and will contain nearly 5 x 107 galaxies to g ~ 23m. The spectroscopic survey will obtain spectra of the brightest 106 galaxies, 105 quasars, and 103.5 rich clusters of galaxies (to g~18.3-19.3m, respectively). I summarize some of the science opportunities that will be made possible by this survey for studying the clustering and large-scale structure of the universe. The survey will identify a complete sample of several thousand rich clusters of galaxies, both in 2D and 3D - the largest automated sample yet available. The extensive cluster sample can be used to determine critical clustering properties such as the luminosity-function, velocity-function, and mass-function of clusters of galaxies (a critical test for cosmological models), detailed cluster dynamics and W(dyn), the cluster correlation function and its dependence on richness, cluster evolution, superclustering and voids to the largest scales yet observed, the motions of clusters and their large-scale peculiar velocity field, as well as detailed correlations between x-ray and optical properties of clusters, the density-morphology relation, and cluster-quasar associations. The large redshift survey, reaching to a depth of 600h-1 Mpc, will accurately map the largest scales yet observed, determine the power-spectrum and correlation function on these large scales for different type galaxies, and study the clustering of quasars to high redshifts (z 4). The implications of the survey for cosmological models, the dark matter, and W are also discussed.
description: compressed PostScript, invited talk presented at the AAS meeting, Minneapolis, June 1994, to appear in PASP 1995; for the figures contact neta@astro.princeton.edu;
Reminiscences of William Averell Harriman, 1979
Publisher: name: Columbia University
Year: 2021
Subjects: Governors--United States
Government executives--United States
Presidents--Election--1952.--United States
Presidents--Election--1956.--United States
Governors--New York (State)

description: Campaign for governor of New York, 1954; Governor, New York, 1955-1958: appointments, policies, programs, and problems; candidate for Democratic presidential nomination, 1952, 1956; Democratic politics, 1950s, national convention, 1956; negotiations with Soviet Union, 1974-79; special representative for various Democratic administrations; Democratic national politics, 1960-79; impressions of Leonid Brezhnev, Tito
A New Dual-Component Photoionization Model for the Narrow Emission-Line Regions in Active Galactic Nuclei
Creators: name: Murayama, Takashi
name: Taniguchi, Yoshiaki
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Having found that type 1 Seyfert nuclei have excess [FeVII]6087 emission with respect to type 2s, Murayama & Taniguchi have proposed that the high-ionization nuclear emission-line region (HINER) traced by the [FeVII]6087 emission resides in the inner wall of dusty tori. The covering factor of the torus is usually large (e.g., ~ 0.9). Further, electron density in the tori (e.g., ~ 10^7-10^8 cm-3) is considered to be higher significantly than that (e.g., ~ 10^3-10^4 cm^-3) in the narrow-line region (NLR). Therefore it is expected that the torus emission contributes to the majority of the higher-ionization emission lines. Taking this HINER component into account, we have constructed new dual-component (i.e., a typical NLR with a HINER torus) photoionization models. Comparison of our model with the observations show that that if the torus emission contributes ~ 10 % of the NLR emission, our dual-component model can explain the observed high [FeVII]6087/[OIII]5007 intensity ratios of the Seyfert 1s without invoking any unusual assumptions (e.g., the overabundance of iron).
description: 12 pages (aaspp4.sty), 2 postscript figures. Accepted for publication in Astrophysical Journal Letters
Functional RNAi analysis of novel regulators of adhesion with further characterisation of the role of LZTFL1 in keratinocytes and heart disease
Creators: name: Bruche, Susann
Publisher: name: Imperial College London
Year: 2014

description: Adherens junctions mediate intercellular adhesion in most tissues. Cell-cell contacts need to be regulated in a variety of biological processes including developmental morphogenesis, wound healing and transendothelial migration. Actin remodelling is crucial for adherens junction control and members of the family of Rho small GTPases are key regulators of adherens junction formation, maintenance and turnover. Although only a few Rho GTPases have been show to date to control adherens junctions, they govern a large number of cellular processes downstream of cadherin interaction by activating different effector proteins. Considering the complexity of adherens junction biology, a complex network of actin-binding proteins and Rho GTPase effectors are likely to mediate adherens junction assembly and preservation. Therefore, we performed RNAi screens and identified several actin-binding proteins and Rho GTPase effectors as novel adherens junction regulators. Here, I validate the role of several of these proteins during adherens junction assembly and further investigate the mechanisms involved for a few of them. Skin and heart are under constant mechanical stress and therefore require specialised cell-cell contacts to ensure tissue integrity. In addition to adherens junctions, epithelial cells and cardiomyocytes possess desmosomes and both complexes warrant junction stability. In this study, I identify LZTFL1 as a protein involved in the stabilisation of cell-cell contacts. LZTFL1 is a tumour suppressor and is involved in trafficking towards cilia. Here I show that LZTFL1 depletion negatively affects adherens junction-associated E-cadherin and actin as well as desmosome-coupled desmoplakin and keratin 14. I further demonstrate that LZTFL1 can bind to α-catenin and keratin 14 and thus might be able to mediate crosstalk between different cell-cell contact complexes. In cardiovascular disease, contraction and mechanical coupling of neighbouring cardiomyocytes need to adapt to changes in pressure and volume load. In accordance with its cell-cell contact-stabilising function in epithelial cells, I detect changes in LZTFL1 expression levels in different cardiac pathologies. These changes are specific to certain pathologies and disease stages and likely represent adaptations to altered mechanical requirements of the heart.
Magnetocaloric properties of La(Fe,Si)13 compounds
Creators: name: Lovell, Edmund
Publisher: name: Imperial College London
Year: 2016

description: La(Fe,Si)13-based compounds are extremely promising for use in magnetocaloric cooling applications. This thesis aims to address multiple challenges to their use in cooling systems, as well as contribute to the fundamental understanding of their first-order magnetic phase transition. A significant field rate dependence in the field-induced paramagnetic (PM) to ferromagnetic (FM) transition in the first-order composition is determined to be a result of non-isothermal conditions from the inherent heating or cooling from the magnetocaloric effect (MCE). Reduction of the magnetic hysteresis has been shown with improved thermal linkage with the thermal bath. Metastability between the phases is demonstrated by magnetic temporal evolution (relaxation). The completion of this evolution is arrested by physical cracks and the sample shape (demagnetising field effects). The onset of the transition is shown to be dominated by the demagnetising fields, and as such a method to reduce magnetic hysteresis via sample shape is demonstrated. These effects are shown to not dominate for samples which show a second-order transition. Mn substitution on the Fe site decreases the strength of the first-order character which is correlated with the relaxation rate, the latent heat decrease and the heat capacity peak increase. Similar correlations are observed with increasing temperature and both the relaxation rate and latent heat go to zero at the critical point, defined by the temperature at which the first-order character (latent heat and hysteresis) disappears. The electronic and spin wave contributions to the low temperature heat capacity are investigated and significant enhancement of the former is shown. This is further enhanced with increased Mn-doping but to a much lesser extent when interstitial hydrogen is introduced to the compound. Suppression of this further enhancement in magnetic field suggest that there are two enhancement mechanisms: a base enhancement likely from electron-phonon interactions, and a second which is magnetic in origin.
Extreme value analysis of ultrasonic thickness measurements
Creators: name: Benstock, Daniel
Publisher: name: Imperial College London
Year: 2015

description: Modern infrastructure and industrial plants have a finite design life. Their effective and profitable operation depends on well organised maintenance and condition assessments. Non-destructive evaluation and inspection is a key tool for condition assessment. However, despite best efforts, full inspection coverage of a plant is not always possible because of access problems, time constraints and limited budgets. Many inspection companies are beginning to use partial coverage inspection (PCI) techniques to solve this problem. PCI describes the use of inspection data collected from a small area of the component to extrapolate to the condition an the rest of the component. Extreme value analysis (EVA) is a technique of particular interest for this application as it allows an inspector to construct a statistical model of the smallest thickness measurements across the component. This model can then be used to extrapolate to the most likely minimum thickness. In this thesis, an analysis of the uncertainties that can arise when using EVA for extrapolation is performed. A clear outline of the uncertainties expected to result from EVA extrapolation is presented and it is made usable for inspectors. In addition, a simple test algorithm to analyse when EVA is suitable for a set of inspection data is described. It is hoped that the work described in this thesis will enhance confidence in the practical use of the technique in the field. Furthermore, the effect of surface roughness on ultrasonic thickness measurements is investigated with joint experimental and computational studies. It is shown that the thickness measurement distribution can differ significantly from the actual thickness distribution, particularly for the smallest values of thickness and with rougher surface conditions. Consequently, extrapolations from extreme value models using ultrasonic thickness data are shown to be conservative compared to the true condition of the component.
MOESM1 of Development of a strictly regulated xylose-induced expression system in Streptomyces
Creators: name: Noguchi, Yuji
name: Kashiwagi, Norimasa
name: Uzura, Atsuko
name: Ogino, Chiaki
name: Kondo, Akihiko
name: Ikeda, Haruo
name: Sota, Masahiro
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additional file 1: Figure S1. SDS-PAGE gels of S. avermitilis protein expression profiles for (A) cell extracts and (B) culture supernatants: 2.0% 1. Glycerol, 2. D-glucose, 3. D-xylose, 4. D-galactose, 5. D-fructose, and 6. no sugar. M: molecular weight marker. Arrows indicate Xylose isomerase (XylA) protein.
Diospyros austroafricana De Winter 1961
Creators: name: Jarvis, Charlie
Publisher: name: Linnaean Society of London in association with the Natural History Museum
Year: 2007
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Ericales
Ebenaceae
Diospyros
Diospyros austroafricana

description: Royena hirsuta Linnaeus, Species Plantarum 1: 397. 1753.
"Habitat ad Cap. b. Spei." RCN: 3131.
Neotype (de Winter in Dyer & al., Fl. Southern Africa 26: 64. 1963): Thunberg 383, Herb. Linn. No. 570.7 (LINN).
Current name: Diospyros austroafricana De Winter (Ebenaceae).
Note: De Winter treated 570.7 (LINN) as the type of this name. While it was clearly not available to Linnaeus in 1753, there is no original material in existence so de Winter’s choice is treated as a neotypification (Art. 9.8).
description: Published as part of Jarvis, Charlie, 2007, Chapter 7: Linnaean Plant Names and their Types (part R), pp. 785-805 in Order out of Chaos. Linnaean Plant Types and their Types, London :Linnaean Society of London in association with the Natural History Museum on page 800, DOI: 10.5281/zenodo.291971
Evaluation of Game Templates to support Programming Activities in Schools
Creators: name: Spieler, Bernadette
name: Schindler, Christian
name: Slany, Wolfgang
name: Mashkina, Olena
name: Beltran, Maria Eugenia
name: Boulton, Helen
name: Brown, David
Publisher: name: arXiv
Year: 2018
Subjects: subject: Computers and Society (cs.CY)
subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: Game creation challenges in schools potentially provide engaging, goal-oriented, and interactive experiences in classes; thereby supporting the transfer of knowledge for learning in a fun and pedagogic manner. A key element of the ongoing European project No One Left Behind (NOLB) is to integrate a game-making teaching framework (GMTF) into the educational app Pocket Code. Pocket Code allows learners to create programs in a visual Lego-style way to facilitate learning how to code at secondary high schools. The concept of the NOLB GMTF is based on principles of the Universal Design for Learning (UDL) model. This framework provides a coherent approach to learning and teaching by integrating leisure oriented gaming methods into multi-discipline curricula. One output of this framework is the integration of game-based methods via game templates that refer to didactical scenarios that include a refined set of genres, assets, rules, challenges, and strategies. These templates allows: 1) teachers to start with a well-structured program, and 2) pupils to add content and adjust the code to integrate their own ideas. During the project game genres such as adventure, action, and quiz, as well as rewards or victory point mechanisms, have been embedded into different subjects, e.g., science, mathematics, and arts. The insights gained during the class hours were used to generate 13 game templates, which are integrated in Create@School (a new version of the Pocket Code app which targets schools). To test the efficiency of these templates, user experience (UX) tests were conducted during classes to compare games created by pupils who used templates and those who started to create a game from scratch. Preliminary results showed that these templates allow learners to focus on subject-relevant problem solving activities rather than on understanding the functionality of the app.
description: 10 pages, 5 figures, 4 tables European Conference of game based learning (ECGBL)
A STRINGENT CONSTRAINT ON ALTERNATIVES TO A MASSIVE BLACK HOLE AT THE CENTER OF NGC 4258
Creators: name: Maoz, Eyal
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: There is now dynamical evidence for massive dark objects at the center of several galaxies, but suggestions that these are supermassive black holes are based only on indirect astrophysical arguments. The recent unprecedented measurement of the rotation curve of maser emission sources at the center of NGC 4258, and the remarkable discovery that it is Keplerian to high precision, provides us a unique opportunity for testing alternatives to a BH (e.g., a massive cluster of stellar remnants, brown dwarfs, low-mass stars, or halo dark matter). We use a conservative upper limit on the systematic deviation from a Keplerian rotation curve to constrain the mass distribution at the galaxy center. Based on evaporation and physical collision time-scale arguments, we show that a central cluster is ruled out, *unless* the cluster consists of *extremely* dense objects with mass less than about 0.05 solar masses (e.g., low mass BHs or elementary particles). Since both of these dynamically-allowed systems are very improbable for other astrophysical reasons, we conclude that a central dense cluster at the center of NGC 4258 is *very* improbable, thus leaving the alternative possibility of a massive BH. We also show that the mass of the BH must be at least 98% of the mass enclosed within the inner edge of the masering disk (3.6*10^7 solar masses). A substantial contribution to that mass from a density cusp in the background mass distribution is excluded.
description: Submitted to ApJ (Letters) on March 15, 1995. 11 pages including 1 figure; uuencoded, compressed postscript.
Quantification of the effects of chimerism on read mapping, differential expression and annotation following short-read de novo assembly.
Creators: name: Linheiro, Raquel
name: Archer, John
Publisher: name: Zenodo
Year: 2022

description: Conference Details:  Genomes of Animals & Plants (GAP2022), 16 - 18th February 2022, Virtual (URL of portal where presentations are. General info here) The poster is based on a paper titled "Quantification of the effects of chimerism on read mapping, differential expression and annotation following short-read de novo assembly" that is available here. Presented by John Archer. Poster Abstract: De novo assembly is often required for analysing short-read RNA sequencing data. An under-charac- terized aspect of the contigs produced is chimerism, the extent to which affects mapping, differential expression analysis and annotation. Despite long-read sequencing negating this issue, short-reads remain in use through on-going research and archived datasets created during the last two decades. Consequently, there is still a need to quantify chimerism and its effects. Related software to this project are:
 1. CStone
 2. CSReadGen
 3. CView
 4. ChimSim <
 5. TVScript A related poster discussing the the identification of chimerism during assembly is available here. General details of the project are available here.
description: The Portuguese Foundation for Science and Technology, FCT, supported this work through project PTDC/BIA-EVL/29115/2017. JA and RL were supported by Funds through FCT under the reference POCI-01-0145-FEDER-029115.
Additional file 1 of Dissection of transcriptomic and epigenetic heterogeneity of grade 4 gliomas: implications for prognosis
Creators: name: Zeng, Chang
name: Song, Xiao
name: Zhang, Zhou
name: Cai, Qinyun
name: Cai, Jiajun
name: Horbinski, Craig
name: Hu, Bo
name: Cheng, Shi-Yuan
name: Zhang, Wei
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1. Fig. S1. (A) The percentages of genes with differential 5hmC modification and expression under different fold change cutoffs. BG denotes background gene; FDR denotes mRNA/lncRNA with FDR <0.05; Up: up-modified/expressed; down: down-modified/expressed. (B) Enriched co-regulated mRNA-mRNA (gene expression) modules are detected in normal controls, IDH1-Mut, and IDH1-WT tumors. (C) Top five enriched KEGG pathways associated with mRNA-mRNA co-regulated modules (FDR < 0.05 and gene count > 5) are shown.
Contribution to the Three--Point Function of the Cosmic Microwave Background from the Rees--Sciama Effect
Creators: name: Mollerach, Silvia
name: Gangui, Alejandro
name: Lucchin, Francesco
name: Matarrese, Sabino
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We compute the contribution to the three--point temperature correlation function of the Cosmic Microwave Background coming from the non--linear evolution of Gaussian initial perturbations, as described by the Rees--Sciama (or integrated Sachs--Wolfe) effect. By expressing the collapsed three--point function in terms of multipole amplitudes, we are able to calculate its expectation value for any power spectrum and for any experimental setting on large angular scales. We also give an analytical expression for the {\it rms} collapsed three--point function arising from the cosmic variance of a Gaussian fluctuation field. In the case of {\it COBE} DMR, we find that the predicted signal is about three orders of magnitude below that expected from the cosmic variance.
description: uuencoded compressed postscript, 10 pages text, 2 pages figures
The role of intraepithelial lymphocytes and type 2 immunity for tissue homeostasis and carcinogenesis in the skin
Creators: name: D'Alessandri, Timothy
Publisher: name: Imperial College London
Year: 2016

description: The skin is under constant renewal whilst frequently being exposed to challenges such as physiochemical disruption and ultraviolet-radiation. How homeostatic control is maintained in the tissue alongside protective mechanisms is poorly understood. Among the basal epithelial cells (EC) is a population of resident intraepithelial lymphocytes (IEL), which provide host-protective immune surveillance (IS). The mouse epidermis is home to a particular IEL termed the dendritic epidermal T cell (DETC). The induction and functions of IS and type 2 immunity at body barrier surfaces remains enigmatic. The aim of this thesis is to investigate the mechanism(s) by which DETC provide IS and maintain epidermal homeostasis. I show that DETC communicate with EC via cytokine IL13. Skin EC are activated by DETC-derived IL13, which enables a canonical EC stress response to various topical challenges. In the absence of IL13, or canonical DETC, the skin is significantly impaired with decreased ability to restore its barrier after insult and increased susceptibility to cutaneous carcinogenesis. Mechanistically, IL13 affected the rate of EC movement through the epidermis, which may explain its importance for epidermal integrity and its suppressive effect on skin carcinogenesis. These findings demonstrate that IL13 acts as a molecular bridge between DETC and EC, and that this interaction provides an integrated local tissue response to perturbation of homeostasis. Finally, I also observed that mice lacking canonical DETC had a reduced ability to repair EC DNA damage following acute carcinogen insult; revealing a hitherto unappreciated aspect of IS. These data support a critical host-defensive role particularly of type 2 immunity in regulating EC tissue homeostasis in multiple settings. Given the considerable and increasing burden of allergic and malignant disease, these data are highly germane to human medicine, and also contribute healthily to the exciting, nascent field studying allergy-cancer interactions; allergooncology.
title: ADCO, Cartulaire de Cîteaux pour les possessions de Saulon-la-Chapelle et Saulon-la-Rue, Fénay, Noiron et la rivière Cent-fonds (XVe siècle), Cart. 179 (11 H 1075), 70 folios, f. 0107
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2015
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Cartulaire de Cîteaux pour les possessions de Saulon-la-Chapelle et Saulon-la-Rue, Fénay, Noiron et la rivière Cent-fonds (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 179 (11 H 1075), 70 folios, f. 0107, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour les possessions de Saulon-la-Chapelle et Saulon-la-Rue, Fénay, Noiron et la rivière Cent-fonds (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 179 (11 H 1075), 70 folios, f. 0107, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Additional file 1 of An ensemble of mathematical models showing diauxic growth behaviour
Creators: name: Kremling, Andreas
name: Geiselmann, Johannes
name: Ropers, Delphine
name: Jong, Hidde De
Publisher: name: figshare
Year: 2018
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Additional file (Pdf format) includes the following sections: 1. Rescaled model equations, 2. Detailed description of model ensemble, 3. Results of cluster analysis, 4. Model fitting. (PDF 699 kb)
title: Θεωρία δειγματοληψίας
Creators: name: Papageorgiou, Ioulia
Publisher: name: Kallipos, Open Academic Editions
Year: 2016
Subjects: ΔΕΙΓΜΑΤΟΛΗΨΙΑ
ΠΕΠΕΡΑΣΜΕΝΟΣ ΠΛΗΘΥΣΜΟΣ
ΣΤΑΤΙΣΤΙΚΗ ΣΥΜΠΕΡΑΣΜΑΤΟΛΟΓΙΑ
Sampling
Finite Populations
Statistical Inference

description: Το βιβλιο αποτελεί ένα εκπαιδευτικό σύγγραμμα στον χώρο της Δειγματοληψίας. Αποτελεί ένα εισαγωγικό βιβλίο που αναπτύσσει τη Θεωρία Δειγματοληψίας. Ειδικότερα, αναπτύσσει τις Τεχνικές Δειγματοληψίας που εφαρμόζονται κατά τη διάρκεια μιας δειγματοληπτικής έρευνας με στόχο τη συλλογή ενός στατιστικού δείγματος. Αρχικά μελετώνται μία προς μία όλες οι γνωστές από την Θεωρία Δειγματοληψίας τεχνικες όπως η απλή τυχαία, η στρωματοποιημένη, η συστηματική, η κατά ομάδες δειγματοληψία και η δειγματοληψία σε πολλα στάδια. Οι κύριοι άξονες ανάπτυξης είναι ο τρόπος υλοποίησης της καθε τεχνικής δειγματοληψίας και η στατιστική συμπερασματολογία, δηλ. η εξαγωγή και επέκταση στον πληθυσμό αποτελεσμάτων που βασίζονται στο υποσύνολο των μετρήσεων του δείγματος. Η στατιστική συμπερασματολογία συμπεριλαμβάνει την εύρεση εκτιμητών για τις σημαντικότερες παραμέτρους του πληθυσμού, τον υπολογισμό tτων στατιστικών σφαλμάτων και την κατασκευή διαστημάτων εμπιστοσύνης. Την μία προς μία μελέτη των βασικότερων τεχνικών δειγματοληψίας ακολουθεί η σύγκριση μεταξύ τους κυρίως ως την ακρίβεια των αποτελεσματων. Ο συνδυασμός επίσης περισσότερων του ενός δειγματοληπτικών σχημάτων μελετάται στα πλαίσια της δειγματοληψίας σε πολλά στάδια. Τέλος μελετώνται θέματα ή προβλήματα που προκύπτουν κατά τη διάρκεια της υλοποίησης μιας δειγματοληπτικής έρευνας κι επηρρεάζουν την ακρίβεια των αποτελεσμάτων της, όπως ο καθορισμός του απαιτούμενου μεγέθους δείγματος και τα σφάλματα λόγω μη-απόκρυψης.

Για την κάθε μέθοδο δειγματοληψίας που μελετάται ανά κεφάλαιο συμπεριλαμβάνονται οι οδηγίες για την υλοποίησή τους με το στατιστικό πακέτο R. Παρέχονται επίσης οι εντολές σε γλώσσα R για την επιλογή του δείγματος και την ανάλυση των δεδομένων. Για την καλύτερη κατανόηση θα παρέχονται παραδείγματα με αριθμητικά δεδομένα. Τα δεδομενα καθώς και οι οδηγίες για τα προγράμματα θα προστεθούν είτε σ' ενα παράρτημα στο τέλος του βιβλίου είτε σ'εναν ηλεκτρονικό σύνδεσμο, author's web site.
Reminiscences of William B. Castle, 1987
Publisher: name: Columbia University
Year: 2020
Subjects: Hematology
Physicians
Pernicious anemia

description: Family history; education; choice of medicine as career; internship at Massachusetts General Hospital; appointment at Harvard School of Public Health; work at Thorndike; professional collaborations; pernicious anemia research; anemia research in Puerto Rico; involvement with American Society of Hematology; reminiscences of colleagues
The epigenetic response to platinum-induced DNA damage and repair
Creators: name: Wilson, Angela
Publisher: name: Imperial College London
Year: 2015

description: Platinum resistance causes treatment failure in a variety of cancers including ovarian cancer. Epigenetic changes can contribute to platinum resistance, as the epigenome is highly divergent between platinum-resistant and -sensitive cells, and DNA demethylating agents partially resensitise resistant cells to platinum. The mismatch repair (MMR) gene MLH1 is epigenetically silenced in certain ovarian cisplatin-resistant cells and links between DNA damage and DNA methylation have been reported. This thesis aims to address the hypothesis that platinum-induced DNA damage causes aberrant DNA methylation, which can be selected for leading to drug resistance, and that the methylation response to platinum damage is influenced by MMR status. Two ovarian cancer cell lines, derived from A2780/CP70, containing a fragment of chromosome 3 with either actively expressed MLH1 (proficient) or an epigenetically silenced MLH1 (deficient) were used to derive individual clones after mock or 5 μM (IC95) cisplatin treatment. LINE-1 methylation was significantly increased only in MLH1-proficient clones after cisplatin treatment. Using the Infinium HumanMethylation450 BeadChip array, methylation was measured at ~480,000 CpGs genome-wide in mock- and cisplatin-treated MLH1-proficient and -deficient clones (n=11 per group). Cisplatin induced bi-directional methylation changes, biased toward hypermethylation, in MLH1-proficient and -deficient clones, with a higher number of DNA methylation changes in MLH1-proficient clones. No detectable genomic location or sequence specificity was observed. In peripheral blood mononuclear cell (PBMC) DNA of ovarian cancer patients treated with carboplatin as part of the SCOTROC1 clinical trial, significant methylation changes were detected using the Infinium methylation array when comparing matched samples collected pre-treatment and at relapse. These methylation changes were, again, biased towards hypermethylation post-platinum treatment and occurred preferentially in non-promoter regions of the genome. This thesis demonstrates for the first time that platinum induces bi-directional DNA methylation changes in cell lines and in PBMCs of ovarian cancer patients and there may be both MLH1-dependent and MLH1-independent mechanisms involved in this response.
LAR@Home 2023 Team Description Paper
Creators: name: Ribeiro, Tiago
name: Gonçalves, Fernando
name: Marco, Luís
name: Eduardo, Fernandes
name: Rui, Silva
name: António, Dias
name: Nuno, Oliveira
name: Diogo, Martins
name: Syed, Fawad
name: Lopes, Gil
name: Ribeiro, A.Fernando
Publisher: name: Zenodo
Year: 2022

description: Video: https://youtu.be/gNx9OYljlcw?si=1I-QBt1PsUUyRL3G
LR Seimo debatai 1990-2020: naujas sistemingas duomenų šaltinis politikos tyrėjams
Creators: name: Briedienė, Monika
Publisher: name: Zenodo
Year: 2021
Subjects: Seimo debatai
Stenogramos
Politikos mokslų duomenys

description: Pranešimas nacionalinės konferencijos „Lietuva po 2020 m. Seimo rinkimų“ specialioje sesijoje: „Lietuvos politinio diskurso tyrimai: 30-mečio tendencijos ir metodologinės inovacijos“. VU TSPMI, 2021 m. kovo 26 d.
description: Konferencijos sesija yra projekto "Lietuvos Seimo politinė darbotvarkė ir jos įrėminimas: 1990–2020 m. Seimo stenogramų analizė", finansuojamo Lietuvos mokslo tarybos (LMTLT) (sutarties Nr. P-MIP-20-373), dalis.
On DDO154 and Cold Dark Matter halo profiles
Creators: name: Gelato, Sergio
name: Sommer-Larsen, Jesper
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We investigate the claim by Burkert and Silk (1997) that the observed rotation curve of the dwarf irregular galaxy DDO154 cannot be reconciled with the universal CDM halo profile of Navarro, Frenk & White (1996,1997) even when allowance is made for the effect of violent gas outflow events on the structure of the galaxy. By means of N-body simulations we show that under certain conditions it is possible to obtain a reasonable fit to the observed rotation curve without invoking Burkert & Silk's proposed spheroidal MACHO component. We are able to best reproduce the observed decline in the rotation curve by postulating additional hidden disc mass, in an amount that is compatible with disc stability requirements. In the process we improve upon the results of Navarro, Eke & Frenk (1996) on the formation of halo cores by mass loss by using actual haloes from Cold Dark Matter simulations instead of Hernquist (1990) distributions.
description: LaTeX (mn.sty), 8 pages, 6 figures included; updated to match final version to appear in MNRAS
The PAU Survey: star-galaxy classification with multi narrow-band data
Creators: name: Cabayol, Laura
name: Sevilla-Noarbe, Ignacio
name: Fernández, Enrique
name: Carretero, Jorge
name: Eriksen, Martin
name: Serrano, Santiago
name: Alarcón, Alex
name: Amara, Adam
name: Casas, Ricard
name: Castander, Francisco Javier
name: de Vicente, Juan
name: Folger, Martin
name: García-Bellido, Juan
name: Gaztanaga, Enrique
name: Hoekstra, Henk
name: Miquel, Ramon
name: Padilla, Cristobal
name: Sánchez, Eusebio
name: Stothert, Lee
name: Tallada, Pau
name: Tortorelli, Luca
Publisher: name: arXiv
Year: 2018
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Classification of stars and galaxies is a well-known astronomical problem that has been treated using different approaches, most of them relying on morphological information. In this paper, we tackle this issue using the low-resolution spectra from narrow band photometry, provided by the PAUS (Physics of the Accelerating Universe) survey. We find that, with the photometric fluxes from the 40 narrow band filters and without including morphological information, it is possible to separate stars and galaxies to very high precision, 98.4% purity with a completeness of 98.8% for objects brighter than I = 22.5. This precision is obtained with a Convolutional Neural Network as a classification algorithm, applied to the objects' spectra. We have also applied the method to the ALHAMBRA photometric survey and we provide an updated classification for its Gold sample.
description: 13 pages, 10 figures, the catalog with the ALHAMBRA classification is available at http://cosmohub.pic.es
Reminiscences of William Bales 1979
Publisher: name: Columbia University
Year: 2019
Subjects: Educators
Choreographers
Dancers
Modern dance

description: Family background; drama and dance studies at Carnegie Tech, 1934; dance instructor with sister in Carnegie and Washington, PA; dance instructor, Irene Kaufman Settlement House; choreography to commemorate Edwin L. Drake's capping of oil well; debut at Radio City Music Hall; study with Jose Limon and Martha Hill; association with Humphrey-Weidman Company; Bennington Summer School of the Dance, 1936, 1938; start of dance program at Bennington; recollections of Cecil Kitkat, Doris Humphrey, Martha Hill, Martha Graham, Robert Devore Leigh, Arch Lauterer.
A faint galaxy redshift survey to B=24
Creators: name: Glazebrook, K.
name: Ellis, R.
name: Colless, M.
name: Broadhurst, T.
name: Allington-Smith, J.
name: Tanvir, N.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Using the multislit LDSS-2 spectrograph on the {\it William Herschel Telescope} we have completed a redshift survey in the magnitude range $22.51$ and includes the highest redshift galaxy ($z=1.108$) yet discovered in a field sample. The median redshift, $\zmed=0.46$, and form of the redshift distribution constitute compelling evidence against simple luminosity evolution as an explanation of the large excess of faint galaxies ($\simeq\times$2--4 no-evolution) seen in this magnitude range. Rather we identify the excess population as blue objects with $z\sim 0.4$ and $B$\, luminosities similar to local $L^*$ galaxies indicating a dramatic decrease in the density of such objects over the last Hubble time, confirming the trends found in brighter redshift surveys. We also find a marked absence of {\it very} low redshift galaxies ($z
description: uuencoded compressed postscript. The preprint are also available at URL http://www.ast.cam.ac.uk/preprint/PrePrint.html
Royena lucida Linnaeus, 1753, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1753
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Ericales
Ebenaceae
Royena
Royena lucida

description: Royena lucida, spec. nov.
 1. Royena foliis ovatis scabriusculis. Hort. cliff. 149. Roy. lugdb. 411.
 Staphylodendron africanum sempervirens, foliis splendentibus. 1. p. 187. t.96.
 Staphylodendrum africanum, folio singulari lucido. Herm. parad. 232. t.232.
 Pistacia africana. Pluk. alm. 298. t. 63. f. 4. t. 317. f. 5.
 Habitat ad Cap. b. Spei . ♄
description: Published as part of Linnaeus, Carolus, 1753, Species plantarum: exhibentes plantas rite cognitas, ad genera relatas, cum differentiis specificis, nominibus trivialibus, synonymis selectis, locis natalibus, secundum systema sexuale digestas, Stockholm :Laurentius Salvius on page 397, DOI: 10.5281/zenodo.3931989
Broad strategies into engineering superior targeted gene therapy vectors derived from bacteriophage viruses
Creators: name: Tsafa, Effrosyni
Publisher: name: Imperial College London
Year: 2016

description: Chemotherapy is the most commonly used treatment for cancer. While chemotherapeutic drugs such as doxorubicin provide cure in some cases, chemotherapy is toxic and has serious side-effects. Another disadvantage is that some types of cancer develop resistance to chemotherapy. Lowering the doses of these drugs will make them safer but would decrease their efficacy. A solution to this would be to combine low doses of these anticancer drugs with a safe anticancer approach. Cancer gene therapy is an alternative and promising approach of cancer treatment. In our group we are using the adeno-associated virus/phage, named AAVP vector, which is a hybrid vector between AAV and phage genomes. AAVP vector was engineered to display the RGD4C peptide which binds to αv integrin receptors overexpressed in tumors. AAVP vector has been proven to be safe and efficient vector for targeted gene delivery to tumors, upon intravenous administration. The aim of my project was to combine low-dose of doxorubicin with AAVP vector in order to investigate the drug effects on the AAVP-mediated tumor cell killing. We also tested the combination of AAVP with the natural dietary genistein, an isoflavone present in soy, regarded as a phytoestrogen and proven for its anti-cancer activity. Epidemiological studies have shown that a soy-rich diet has cancer-preventive effects. We found that combination of low doses (non-toxic) of doxorubicin or genistein with RGD4C-AAVP-guided gene therapy resulted in greater tumor cell killing than treatment with doxorubicin, genistein or the targeted vector alone. In addition, we uncovered the mechanism that doxorubicin and genistein increased the transduction efficiency of AAVP vectors. In conclusion, our results suggest that the combined treatment of doxorubicin or genistein with targeted RGD4C-AAVP gene therapy is a novel, promising, non-invasive and, importantly, safer treatment approach. Therefore, this combined treatment should be considered for future preclinical studies to assess its efficacy in vivo in tumor-bearing animals.
Additional file 2 of Dissection of transcriptomic and epigenetic heterogeneity of grade 4 gliomas: implications for prognosis
Creators: name: Zeng, Chang
name: Song, Xiao
name: Zhang, Zhou
name: Cai, Qinyun
name: Cai, Jiajun
name: Horbinski, Craig
name: Hu, Bo
name: Cheng, Shi-Yuan
name: Zhang, Wei
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2. Fig. S2. (A) Network hubs of co-regulated 5hmC-mRNA module M1. (B) Network hubs of co-regulated 5hmC-mRNA module M5. (C-F) Network hubs of co-regulated 5hmC-5hmC module. (G-K) Network hubs of co-regulated mRNA modules. CE denotes co-expression/regulation hubs; INT denotes protein-protein interaction hubs; CE+INT denotes co-expression/regulation and protein-protein interaction hubs.
Pocket Game Jams: a Constructionist Approach at Schools
Creators: name: Petri, Anja
name: Schindler, Christian
name: Slany, Wolfgang
name: Spieler, Bernadette
name: Smith, Jonathan
Publisher: name: arXiv
Year: 2018
Subjects: subject: Computers and Society (cs.CY)
subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: The constructionist approach is more interested in constructing personal experience than about acquiring information. It states that learning is most effective when building knowledge through active engagement. Experiential and discovery learning by challenges inspire creativity, and projects allow independent thinking and new ways of learning information. This paper describes how the "No One Left Behind" (NOLB) project plans to integrate this approach into school curricula using two concepts. The first one is to enable students to create their own games with Pocket Code by using its easy-to-learn visual programming language. The second concept is to foster collaboration and teamwork through hands-on sessions by conducting Game Jams using Pocket Code, so called Pocket Game Jams. We present insights into such a Pocket Game Jam and give an outlook on how we will use this concept.
description: 5 pages, MobiHCI 2015