cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Isoform-Specific Upregulation of Palladin in Human and Murine Pancreas Tumors
Creators: name: Cukierman, Edna
name: Bentrem, David J.
name: McCulloch, Christopher A. G.
name: Otey, Carol A.
name: Yeh, Jen Jen
name: Kim, Hong Jin
name: Thorne, Leigh
name: Goicoechea, Silvia M.
name: Cowan, David W.
name: Volmar, Keith
name: Brentnall, Teresa
name: Bednarski, Brian
name: Rustgi, Anil K.
name: Hochwald, Steven N.
name: Stack, Christianna
name: Hwang, Rosa F.
name: Hingorani, Sunil R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Pancreatic ductal adenocarcinoma (PDA) is a lethal disease with a characteristic pattern of early metastasis, which is driving a search for biomarkers that can be used to detect the cancer at an early stage. Recently, the actin-associated protein palladin was identified as a candidate biomarker when it was shown that palladin is mutated in a rare inherited form of PDA, and overexpressed in many sporadic pancreas tumors and premalignant precursors. In this study, we analyzed the expression of palladin isoforms in murine and human PDA and explored palladin's potential use in diagnosing PDA. We performed immunohistochemistry and immunoblot analyses on patient samples and tumor-derived cells using an isoform-selective monoclonal antibody and a pan-palladin polyclonal antibody. Immunoblot and real-time quantitative reverse transcription-PCR were used to quantify palladin mRNA levels in human samples. We show that there are two major palladin isoforms expressed in pancreas: 65 and 85–90 kDa. The 65 kDa isoform is expressed in both normal and neoplastic ductal epithelial cells. The 85–90 kDa palladin isoform is highly overexpressed in tumor-associated fibroblasts (TAFs) in both primary and metastatic tumors compared to normal pancreas, in samples obtained from either human patients or genetically engineered mice. In tumor-derived cultured cells, expression of palladin isoforms follows cell-type specific patterns, with the 85–90 kDa isoform in TAFs, and the 65 kDa isoform predominating in normal and neoplastic epithelial cells. These results suggest that upregulation of 85–90 kDa palladin isoform may play a role in the establishment of the TAF phenotype, and thus in the formation of a desmoplastic tumor microenvironment. Thus, palladin may have a potential use in the early diagnosis of PDA and may have much broader significance in understanding metastatic behavior.
INFLUENCE OF CONSUMER EDUCATION ON THE PURCHASE OF ASO-EBI IN POST COVID-19 ERA IN SOUTH WEST NIGERIA (African Journal of Studies in Education, AJOSIE, 17(1), 2022)
Creators: name: Oluwagbemileke, Feranmi Boluwatife
Publisher: name: figshare
Year: 2023
Subjects: Consumer behaviour
Textile and fashion design

description: Functional consumer education is needed to help Nigerians make efficient consumption fo goodsand servicsespecially after the COVID-19 Pandemic. This study investigated the extent of peoples’ awareness of consumer education and the way they applied their knowledge in the consumption of uniform clothing in the post COVID-19 era. Three research questions and one null hypothesis guided the study. This study employed a descriptive survey research design. A sample of 1,200 respondents was selected from the population of the study (all adults in South-Western geo-political zone of Nigeria, who are estimated to be 38,783,554) using Yaro Yamane Formula. Self-structured “Consumer Education on the Choice and Usage of Aso-Ebi Questionnaire” (CECUAQ) which was validated by three experts and produced a high Cronbach’s alpha value of reliability (0.86)was used for data collection. The data were analyzed using mean, standard deviation, Pearson Product Momention coefficient (Pearson’s R), and t-test. Major findings are that the level of awareness of consumer education among aso-ebi users and the extent to which this knowledge is applied to the consumption of Aso-ebi clothing in South-West Nigeria are both high. It was therefore recommended that Consumer Protection Agencies should protect and promote the interests of aso-ebi consumers against unfair practices
LIGHT Induces Distinct Signals to Clear an AAV-Expressed Persistent Antigen in the Mouse Liver and to Induce Liver Inflammation
Creators: name: Kovalev, Grigoriy I.
name: Fu, Yang-Xin
name: Washburn, Michael L.
name: Su, Lishan
name: Koroleva, Ekaterina
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: BackgroundInfection with adeno-associated virus (AAV) vector with liver tropism leads to persistent expression of foreign antigens in the mouse liver, with no significant liver inflammation or pathology. This provides a model to investigate antigen persistence in the liver and strategies to modulate host immunity to reduce or clear the foreign antigen expressed from AAV vector in the liver.Methods/Principal FindingsWe showed that expressing LIGHT with an adenovirus vector (Ad) in mice with established AAV in the liver led to clearance of the AAV. Ad-LIGHT enhanced CD8 effector T cells in the liver, correlated with liver inflammation. LTβR-Ig proteins blocked Ad-LIGHT in clearing AAV. Interestingly, in LTβR-null mice, Ad-LIGHT still cleared AAV but caused no significant liver inflammation.Conclusions/SignificanceOur data suggest that LIGHT interaction with the LTβR plays a critical role in liver inflammation but is not required for LIGHT-mediated AAV clearance. These findings will shed light on developing novel immuno-therapeutics in treating people chronically infected with hepato-tropic viruses.
"SALOTI MAS'UDIY" ASARINING BOBLARGA KО'RA TASNIFI
Creators: name: Usmanova, Xulkar
Publisher: name: Zenodo
Year: 2024

description: Mas’ud Samarqandiyning (XIII asr oxiri va XIV asr boshlari) “Saloti Mas’udiy” asari boshida keltirilgan aqida risolasi musulmonlarga о‘z e’tiqodlarini mustahkamlashga yordam bersa, fiqhiy qismi esa ibodatlari, xulqlari va hayot tarzlarini chiroyli qilib qurishlariga kо‘mak beradi. Shuningdek, ularning diniy-huquqiy sohadagi kо‘plab savollariga yetarlicha, asosli javob beradi. Mazkur maqolada asarning boblarga kо‘ra mavzulari yoritib berilgan.
ObjectMix: Data Augmentation by Copy-Pasting Objects in Videos for Action Recognition
Creators: name: Kimata, Jun
name: Nitta, Tomoya
name: Tamaki, Toru
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: In this paper, we propose a data augmentation method for action recognition using instance segmentation. Although many data augmentation methods have been proposed for image recognition, few of them are tailored for action recognition. Our proposed method, ObjectMix, extracts each object region from two videos using instance segmentation and combines them to create new videos. Experiments on two action recognition datasets, UCF101 and HMDB51, demonstrate the effectiveness of the proposed method and show its superiority over VideoMix, a prior work.
description: ACM Multimedia Asia (MMAsia '22), December 13--16, 2022, Tokyo, Japan
Maternal Investment Influences Expression of Resource Polymorphism in Amphibians: Implications for the Evolution of Novel Resource-Use Phenotypes
Creators: name: Pfennig, David W.
name: Martin, Ryan A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Maternal effects—where an individual's phenotype is influenced by the phenotype or environment of its mother—are taxonomically and ecologically widespread. Yet, their role in the origin of novel, complex traits remains unclear. Here we investigate the role of maternal effects in influencing the induction of a novel resource-use phenotype. Spadefoot toad tadpoles, Spea multiplicata, often deviate from their normal development and produce a morphologically distinctive carnivore-morph phenotype, which specializes on anostracan fairy shrimp. We evaluated whether maternal investment influences expression of this novel phenotype. We found that larger females invested in larger eggs, which, in turn, produced larger tadpoles. Such larger tadpoles are better able to capture the shrimp that induce carnivores. By influencing the expression of novel resource-use phenotypes, maternal effects may play a largely underappreciated role in the origins of novelty.
Propagation and energy deposition of cosmic rays' muons on terrestrial environments
Creators: name: Marinho, Franciole
name: Paulucci, Laura
name: Galante, Douglas
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Earth is constantly struck by radiation coming from the interstellar medium. The very low energy end of the spectrum is shielded by the geomagnetic field but charged particles with energies higher than the geomagnetic cutoff will penetrate the atmosphere and are likely to interact, giving rise to secondary particles. Some astrophysical events, such as gamma ray bursts and supernovae, when happening at short distances, may affect the planet's biosphere due to the temporary enhanced radiation flux. Muons are abundantly produced by high energy cosmic rays in the Earth's atmosphere. These particles, due to their low cross section, are able to penetrate deep underground and underwater, with the possibility of affecting biological niches normally considered shielded from radiation. We investigate the interaction of muons produced by high energy cosmic rays on Earth's atmosphere using the Geant4 toolkit. We analyze penetration power in water and crust and also the interaction effects within bacteria-like material according to particle type and energy, and notice the possibility of off-track damage due to secondary particles.
description: 15 pages, 6 figures
Canadian Gallup Poll # 299
Creators: name: Canadian Institute Of Public Opinion (Gallup)
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Federal election vote intent(1); past federal elections vote(1); unification of churches(1); Prime Minister and the opposition leader job performances(4); Canada and the Common Market(2); TV news reporting(4); trade with communist countries(1); chances of world war(1); right to strike(2); nuclear weapons for Canadian armed forces(1). Note: Demographics(12).
Faster Separators for Shallow Minor-Free Graphs via Dynamic Approximate Distance Oracles
Creators: name: Wulff-Nilsen, Christian
Publisher: name: arXiv
Year: 2014
Subjects: subject: Data Structures and Algorithms (cs.DS)
subject: FOS: Computer and information sciences
subject: E.1; G.2.2

description: Plotkin, Rao, and Smith (SODA'97) showed that any graph with $m$ edges and $n$ vertices that excludes $K_h$ as a depth $O(\ell\log n)$-minor has a separator of size $O(n/\ell + \ell h^2\log n)$ and that such a separator can be found in $O(mn/\ell)$ time. A time bound of $O(m + n^{2+ε}/\ell)$ for any constant $ε> 0$ was later given (W., FOCS'11) which is an improvement for non-sparse graphs. We give three new algorithms. The first has the same separator size and running time $O(\mbox{poly}(h)\ell m^{1+ε})$. This is a significant improvement for small $h$ and $\ell$. If $\ell = Ω(n^{ε'})$ for an arbitrarily small chosen constant $ε' > 0$, we get a time bound of $O(\mbox{poly}(h)\ell n^{1+ε})$. The second algorithm achieves the same separator size (with a slightly larger polynomial dependency on $h$) and running time $O(\mbox{poly}(h)(\sqrt\ell n^{1+ε} + n^{2+ε}/\ell^{3/2}))$ when $\ell = Ω(n^{ε'})$. Our third algorithm has running time $O(\mbox{poly}(h)\sqrt\ell n^{1+ε})$ when $\ell = Ω(n^{ε'})$. It finds a separator of size $O(n/\ell) + \tilde O(\mbox{poly}(h)\ell\sqrt n)$ which is no worse than previous bounds when $h$ is fixed and $\ell = \tilde O(n^{1/4})$. A main tool in obtaining our results is a novel application of a decremental approximate distance oracle of Roditty and Zwick.
description: 16 pages. Full version of the paper that appeared at ICALP'14. Minor fixes regarding the time bounds such that these bounds hold also for non-sparse graphs
Methamphetamine Use among Newly Diagnosed HIV-Positive Young Men in North Carolina, United States, from 2000 to 2005
Creators: name: Leone, Peter
name: Foust, Evelyn
name: Green, Kelly
name: Hurt, Christopher B.
name: Torrone, Elizabeth
name: Hightow-Weidman, Lisa
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: BackgroundMethamphetamine (MA) is a new arrival to the Southeastern United States (US). Incidence of HIV is also increasing regionally, but data are limited regarding any association between this trend and MA use. We examined behavioral data from North Carolina (NC) residents newly diagnosed with HIV, collected by the Department of Health between 2000-2005.Principal FindingsAmong 1,460 newly diagnosed HIV-positive young men, an increasing trend was seen from 2000-2005 in MA use (p = 0.01, total n = 20). In bivariate analyses, users of MA had significantly greater odds of reporting other substance use, including alcohol, powder or crack cocaine, marijuana, and methylenedioxymethamphetamine (MDMA, “ecstasy”). They were also more likely to have reported sexual activity while traveling outside NC; sex with anonymous partners; and previous HIV testing. In a predictive model, MA use had a negative association with nonwhite race, and strong positive associations with powder cocaine, “ecstasy,” or intravenous drug use and being a university student.ConclusionsSimilar to trends seen in more urban parts of the US, MA use among newly diagnosed, HIV-positive young men is increasing in NC. These data are among the first to demonstrate this relationship in a region with a burgeoning epidemic of MA use. Opportunities exist for MA-related HIV risk-reduction interventions whenever young men intersect the healthcare system.
A Robin-Neumann Scheme with Quasi-Newton Acceleration for Partitioned Fluid-Structure Interaction
Creators: name: Spenke, Thomas
name: Make, Michel
name: Hosters, Norbert
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computational Engineering, Finance, and Science (cs.CE)
subject: Numerical Analysis (math.NA)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: The Dirichlet-Neumann scheme is the most common partitioned algorithm for fluid-structure interaction (FSI) and offers high flexibility concerning the solvers employed for the two subproblems. Nevertheless, it is not without shortcomings: to begin with, the inherent added-mass effect often destabilizes the numerical solution severely. Moreover, the Dirichlet-Neumann scheme cannot be applied to FSI problems in which an incompressible fluid is fully enclosed by Dirichlet boundaries, as it is incapable of satisfying the volume constraint. In the last decade, interface quasi-Newton methods have proven to control the added-mass effect and substantially speed up convergence by adding a Newton-like update step to the Dirichlet-Neumann coupling. They are, however, without effect on the incompressibility dilemma. As an alternative, the Robin-Neumann scheme generalizes the fluid's boundary condition to a Robin condition by including the Cauchy stresses. While this modification in fact successfully tackles both drawbacks of the Dirichlet-Neumann approach, the price to be paid is a strong dependency on the Robin weighting parameter, with very limited a priori knowledge about good choices. This work proposes a strategy to merge these two ideas and benefit from their combined strengths. The resulting quasi-Newton-accelerated Robin-Neumann scheme is compared to both Robin- and Dirichlet-Neumann variants. The numerical tests demonstrate that it does not only provide faster convergence, but also massively reduces the influence of the Robin parameter, mitigating the main drawback of the Robin-Neumann algorithm.
description: Keywords: Partitioned Fluid-Structure Interaction, Robin-Neumann Scheme,Interface Quasi-Newton Methods
MiRNA Profile Associated with Replicative Senescence, Extended Cell Culture, and Ectopic Telomerase Expression in Human Foreskin Fibroblasts
Creators: name: Jarstfer, Michael B.
name: Bonifacio, Laura N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Senescence is a highly regulated process that limits cellular replication by enforcing a G1 arrest in response to various stimuli. Replicative senescence occurs in response to telomeric DNA erosion, and telomerase expression can offset replicative senescence leading to immortalization of many human cells. Limited data exists regarding changes of microRNA (miRNA) expression during senescence in human cells and no reports correlate telomerase expression with regulation of senescence-related miRNAs. We used miRNA microarrays to provide a detailed account of miRNA profiles for early passage and senescent human foreskin (BJ) fibroblasts as well as early and late passage immortalized fibroblasts (BJ-hTERT) that stably express the human telomerase reverse transcriptase subunit hTERT. Selected miRNAs that were differentially expressed in senescence were assayed for expression in quiescent cells to identify miRNAs that are specifically associated with senescence-associated growth arrest. From this group of senescence-associated miRNAs, we confirmed the ability of miR-143 to induce growth arrest after ectopic expression in young fibroblasts. Remarkably, miR-143 failed to induce growth arrest in BJ-hTERT cells. Importantly, the comparison of late passage immortalized fibroblasts to senescent wild type fibroblasts reveals that miR-146a, a miRNA with a validated role in regulating the senescence associated secretory pathway, is also regulated during extended cell culture independently of senescence. The discovery that miRNA expression is impacted by expression of ectopic hTERT as well as extended passaging in immortalized fibroblasts contributes to a comprehensive understanding of the connections between telomerase expression, senescence and processes of cellular aging.
Siena Research Institute Poll: February 2013 Siena New York State Index of Consumer Sentiment
Creators: name: Siena Research Institute, Siena College
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Personal financial situation (2); New York business conditions (2); good time to buy (1); planned future purchases (5); impact of gas prices (1); impact of food prices (1); real estate market conditions (6).
Investigating the possible connection between lambda Bootis stars and intermediate Population II type stars
Creators: name: Paunzen, E.
name: Iliev, I. Kh.
name: Fossati, L.
name: Heiter, U.
name: Weiss, W. W.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The lambda Bootis (LB) stars are located at the upper main sequence of the H-R diagram and exhibit a peculiar abundance pattern. The light elements (C, N, O, and S) present solar abundances whereas all other elements are moderately to strongly underabundant. It has not yet been determined whether that abundance pattern is intrinsic, or is restricted to the stellar surface. If we follow the hypothesis that the LB stars are intrinsically metal-weak, then there should be a connection with the intermediate Population II and F-weak objects. Such a possible affinity has not been previously investigated. We present detailed elemental abundances, including those of the light elements carbon and oxygen, for 38 bright intermediate Population II and F-weak objects. In addition, we investigate the kinematic characteristics of the groups. From photometric, spectroscopic, and kinematic data, there is no distinction between the intermediate Population II and F-weak type stars. We therefore conclude that the two groups are identical. However, it is possible to distinguish the LB stars from the intermediate Population II stars on the basis of elemental abundances, though not in terms of their kinematics. The LB stars seem to be distinct from the intermediate Population II group. Further asteroseismologic investigations and analyses of spectroscopic binary systems are needed to strengthen this conclusion.
description: 9 pages, 5 figures, 4 tables, Accepted in A&A
Development of silica nanoparticle transdermal delivery systems for cannabidiol
Creators: name: Partalis, Connie
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: There is a broad range of literature focused on Cannabis sativa but these clinical trials often feature dosages of unrefined plant products with an unknown mix of chemicals, or studies involve a combination of the two main components; cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC). When isolated, CBD is non-psychoactive with therapeutic potential in treating pain and inflammation, well-tolerated with few side effects. However, oral formulations are hampered by needing high doses to combat first-pass metabolism. It requires a more efficient route of distribution. Instead of a common oral route, this research focuses on designing a novel system for transdermal drug delivery through characterisation, stability and release measurements of CBD-encapsulated organosilica nanoparticles. A novel formulation of CBD-encapsulated nanoparticles at 15 wt% loading was casted with polyvinyl alcohol (PVA) to simulate a nanofiber mat, typical of pharmaceutical patch formulations. In degradation studies, CBD-encapsulated nanoparticles and PVA-casted mats stay stable up to 4 weeks in a storage environment of 40°C and 70% humidity. Release measurements using a dissolution bath demonstrated the ability of PVA-casted particles to enhance release of CBD by 35% in simulated sweat compared to oral media. Franz cell transdermal release corroborates previous data, the effect based on CBD-particle dispersion within the PVA-film.
Canadian Gallup Omnibus Poll # 103-1
Creators: name: Inc., The Canadian Gallup Poll
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Federal and provincial elections vote intent(2); past federal and provincial elections vote(2); Prime Minister Mulroney's handling of Canadian involvement in the Persian Gulf war(1); best choice for Prime Minister(1); federal budget(2); federal government new Citizen Forum on Canada's Future(2); North American free trade zone(4); try Saddam Hussein as war criminal(2). Note: Standard demographics(17).
Molecular Determinants of Survival Motor Neuron (SMN) Protein Cleavage by the Calcium-Activated Protease, Calpain
Creators: name: Strayer, Molly S.
name: Matera, A. Gregory
name: Fuentes, Jennifer L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Spinal muscular atrophy (SMA) is a leading genetic cause of childhood mortality, caused by reduced levels of survival motor neuron (SMN) protein. SMN functions as part of a large complex in the biogenesis of small nuclear ribonucleoproteins (snRNPs). It is not clear if defects in snRNP biogenesis cause SMA or if loss of some tissue-specific function causes disease. We recently demonstrated that the SMN complex localizes to the Z-discs of skeletal and cardiac muscle sarcomeres, and that SMN is a proteolytic target of calpain. Calpains are implicated in muscle and neurodegenerative disorders, although their relationship to SMA is unclear. Using mass spectrometry, we identified two adjacent calpain cleavage sites in SMN, S192 and F193. Deletion of small motifs in the region surrounding these sites inhibited cleavage. Patient-derived SMA mutations within SMN reduced calpain cleavage. SMN(D44V), reported to impair Gemin2 binding and amino-terminal SMN association, drastically inhibited cleavage, suggesting a role for these interactions in regulating calpain cleavage. Deletion of A188, a residue mutated in SMA type I (A188S), abrogated calpain cleavage, highlighting the importance of this region. Conversely, SMA mutations that interfere with self-oligomerization of SMN, Y272C and SMNΔ7, had no effect on cleavage. Removal of the recently-identified SMN degron (Δ268-294) resulted in increased calpain sensitivity, suggesting that the C-terminus of SMN is important in dictating availability of the cleavage site. Investigation into the spatial determinants of SMN cleavage revealed that endogenous calpains can cleave cytosolic, but not nuclear, SMN. Collectively, the results provide insight into a novel aspect of the post-translation regulation of SMN.
(:unas) unassigned
Creators: name: (:Unkn) Unknown
Publisher: name: Universita' degli Studi di Salerno
Year: 2024

description: L’Olimpiade è una delle opere più note di Pietro Metastasio, considerata “esemplare” della sua idea di teatro nella fase matura, come Didone abbandonata per la fase giovanile. Fu musicata da almeno cinquanta compositori e alcune arie di questo dramma per musica furono conosciutissime e cantate come canzoni popolari; per questo risulta di un certo interesse parlare della fortuna di Olimpiade attraverso una di queste celebri arie: «Più non si trovano | fra mille amanti». Di questo cavallo di battaglia seguiamo i percorsi teatral-musicali dagli esordi viennesi fino agli anni Ottanta del Settecento, quando il testo di «Più non si trovano» suscitò l’attenzione di Mozart.
description: The Olimpiade is one of the best known works by Pietro Metastasio: it is considered “exemplary” for his idea of theatre in the mature phase, like Dido abandoned for the youth phase. It was set to music by at least fifty composers, and some arias of this musical drama were well known and sung as popular songs; for this reason, it is of some interest to talk about the fortune of the Olimpiade through one of these famous arias: «Più non si trovano | fra mille amanti». We follow the theatrical-musical paths of this workhorse from the Viennese beginnings up to the 1780s, when the text of «Più non si trovano» aroused Mozart’s attention.
Neural Activity Patterns in Response to Interspecific and Intraspecific Variation in Mating Calls in the Túngara Frog
Creators: name: Burmeister, Sabrina S.
name: Mangiamele, Lisa A.
name: Chakraborty, Mukta
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: BackgroundDuring mate choice, individuals must classify potential mates according to species identity and relative attractiveness. In many species, females do so by evaluating variation in the signals produced by males. Male túngara frogs (Physalaemus pustulosus) can produce single note calls (whines) and multi-note calls (whine-chucks). While the whine alone is sufficient for species recognition, females greatly prefer the whine-chuck when given a choice.Methodology/Principal FindingsTo better understand how the brain responds to variation in male mating signals, we mapped neural activity patterns evoked by interspecific and intraspecific variation in mating calls in túngara frogs by measuring expression of egr-1. We predicted that egr-1 responses to conspecific calls would identify brain regions that are potentially important for species recognition and that at least some of those brain regions would vary in their egr-1 responses to mating calls that vary in attractiveness. We measured egr-1 in the auditory brainstem and its forebrain targets and found that conspecific whine-chucks elicited greater egr-1 expression than heterospecific whines in all but three regions. We found no evidence that preferred whine-chuck calls elicited greater egr-1 expression than conspecific whines in any of eleven brain regions examined, in contrast to predictions that mating preferences in túngara frogs emerge from greater responses in the auditory system.ConclusionsAlthough selectivity for species-specific signals is apparent throughout the túngara frog brain, further studies are necessary to elucidate how neural activity patterns vary with the attractiveness of conspecific mating calls.
Prethermal nematic order and staircase heating in a driven frustrated Ising magnet with dipolar interactions
Creators: name: Jin, Hui-Ke
name: Pizzi, Andrea
name: Knolle, Johannes
Publisher: name: arXiv
Year: 2022
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Many-body systems subject to a high-frequency drive can show intriguing thermalization behavior. Prior to heating to a featureless infinite-temperature state, these systems can spend an exponentially long time in prethermal phases characterized by various kinds of order. Here, we uncover the rich non-equilibrium phase diagram of a driven frustrated two-dimensional Ising magnet with competing short-range ferromagnetic and long-range dipolar interactions. We show that the ordered stripe and nematic phases, which appear in equilibrium as a function of temperature, underpin subsequent prethermal phases in a new multi-step heating process en route towards the ultimate heat death. We discuss implications for experiments on ferromagnetic thin films and other driving induced phenomena in frustrated magnets.
description: 6 pages + 4 figures
Canadian Gallup Poll # 460-1A
Creators: name: Canadian Institute Of Public Opinion (Gallup)
Publisher: name: Roper Center for Public Opinion Research
Year: 2020

description: Federal election vote intent(1); past federal elections vote(1); family life(1); teachers in the community(2); ideal number of children in family(1); labor unions(1); job satisfaction(1); Russia's global influence(1); threat of dissolution of the Confederation(1). Note: Demographics(15).
Phenex: Ontological Annotation of Phenotypic Diversity
Creators: name: Dahdul, Wasila M.
name: Vision, Todd J.
name: Westerfield, Monte
name: Mabee, Paula
name: Lapp, Hilmar
name: Midford, Peter E.
name: Kothari, Cartik R.
name: Balhoff, James P.
name: Lundberg, John G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: BackgroundPhenotypic differences among species have long been systematically itemized and described by biologists in the process of investigating phylogenetic relationships and trait evolution. Traditionally, these descriptions have been expressed in natural language within the context of individual journal publications or monographs. As such, this rich store of phenotype data has been largely unavailable for statistical and computational comparisons across studies or integration with other biological knowledge.Methodology/Principal FindingsHere we describe Phenex, a platform-independent desktop application designed to facilitate efficient and consistent annotation of phenotypic similarities and differences using Entity-Quality syntax, drawing on terms from community ontologies for anatomical entities, phenotypic qualities, and taxonomic names. Phenex can be configured to load only those ontologies pertinent to a taxonomic group of interest. The graphical user interface was optimized for evolutionary biologists accustomed to working with lists of taxa, characters, character states, and character-by-taxon matrices.Conclusions/SignificanceAnnotation of phenotypic data using ontologies and globally unique taxonomic identifiers will allow biologists to integrate phenotypic data from different organisms and studies, leveraging decades of work in systematics and comparative morphology.
Potential high-$T_{c}$ superconductivity in YCeH$_{x}$ and LaCeH$_{x}$ under pressure
Creators: name: Song, Peng
name: Hou, Zhufeng
name: Nakano, Kousuke
name: Hongo, Kenta
name: Maezono, Ryo
Publisher: name: arXiv
Year: 2022
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Lanthanum, yttrium, and cerium hydrides are the three most well-known superconducting binary hydrides (La-H, Y-H, and Ce-H systems), which have gained great attention in both theoretical and experimental studies. Recent studies have shown that ternary hydrides composed of lanthanum and yttrium can achieve high superconductivity around 253 K. In this study we employ the evolutionary-algorithm-based crystal structure prediction (CSP) method and first-principles calculations to investigate the stability and superconductivity of ternary hydrides composed of (Y, Ce) and (La, Ce) under high pressure. Our calculations show that there are multiple stable phases in Y-Ce-H and La-Ce-H systems, among which $P4/mmm$-YCeH$_{8}$, $P\bar{6}m2$-YCeH$_{18}$, $R\bar{3}m$-YCeH$_{20}$, $P4/mmm$-LaCeH$_{8}$, and $R\bar{3}m$-LaCeH$_{20}$ possessing H$_{18}$, H$_{29}$ and H$_{32}$ clathrate structures can maintain both the thermodynamic and lattice-dynamic stabilities. In addition, we also find that these phases also maintain a strong resistance to decomposition at high temperature. Electron-phonon coupling calculations show that only three of these five phases can exhibit high-temperature superconductivity. The superconducting transition temperatures ($T_\mathrm{c}$) of $R\bar{3}m$-YCeH$_{20}$, $R\bar{3}m$-LaCeH$_{20}$, and $P\bar{6}m2$-YCeH$_{18}$ are predicted using the Allen-Dynes-modified McMillan formula to be 122 K at 300 GPa, 116 K at 250 GPa, and 173 K at 150 GPa, respectively. Moreover, the pressure to stabilize $P\bar{6}m2$-YCeH$_{18}$ can be lowered to 150 GPa, suggesting an accessible condition for its high-pressure synthesis.
description: 5 figures
Factors affecting the family development index in Indonesia: a survey in Aceh, a region with 30-years armed conflict and under Shariah law
Creators: name: Yani, Muhammad
Publisher: name: figshare
Year: 2022
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Master data for a submission entitled “Factors affecting the family development index in Indonesia: a survey in Aceh, a region with 30-years armed conflict and under Shariah law” submitted to F1000 Research
Potential Tumor Suppressor Role for the c-Myb Oncogene in Luminal Breast Cancer
Creators: name: Parker, Joel S.
name: Hoadley, Katherine A.
name: Thorner, Aaron R.
name: Perou, Charles M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: BackgroundThe transcription factor c-Myb has been well characterized as an oncogene in several human tumor types, and its expression in the hematopoietic stem/progenitor cell population is essential for proper hematopoiesis. However, the role of c-Myb in mammopoeisis and breast tumorigenesis is poorly understood, despite its high expression in the majority of breast cancer cases (60–80%).Methodology/Principal FindingsWe find that c-Myb high expression in human breast tumors correlates with the luminal/ER+ phenotype and a good prognosis. Stable RNAi knock-down of endogenous c-Myb in the MCF7 luminal breast tumor cell line increased tumorigenesis both in vitro and in vivo, suggesting a possible tumor suppressor role in luminal breast cancer. We created a mammary-derived c-Myb expression signature, comprised of both direct and indirect c-Myb target genes, and found it to be highly correlated with a published mature luminal mammary cell signature and least correlated with a mammary stem/progenitor lineage gene signature.Conclusions/SignificanceThese data describe, for the first time, a possible tumor suppressor role for the c-Myb proto-oncogene in breast cancer that has implications for the understanding of luminal tumorigenesis and for guiding treatment.
Fundamental Physics with ESPRESSO, Constraining a simple parametrisation for varying $α$
Creators: name: da Fonseca, Vitor
name: Barreiro, Tiago
name: Nunes, Nelson J.
name: Cristiani, Stefano
name: Cupani, Guido
name: D'Odorico, Valentina
name: Santos, Ricardo Génova
name: Leite, Ana C. O.
name: Marques, Catarina M. J.
name: Martins, Carlos J. A. P.
name: Milaković, Dinko
name: Molaro, Paolo
name: Murphy, Michael T.
name: Schmidt, Tobias M.
name: Abreu, Manuel
name: Adibekyan, Vardan
name: Cabral, Alexandre
name: Di Marcantonio, Paolo
name: Hernández, Jonay I. González
name: Palle, Enric
name: Pepe, Francesco A.
name: Rebolo, Rafael
name: Santos, Nuno C.
name: Sousa, Sérgio G.
name: Sozzetti, Alessandro
name: Mascareño, Alejandro Suárez
name: Osorio, Maria-Rosa Zapatero
Publisher: name: arXiv
Year: 2022
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The spectrograph ESPRESSO recently obtained a limit on the variation of the fine-structure constant, $α$, through measurements along the line of sight of a bright quasar with a precision of $1.36$ ppm at $1σ$ level. This imposes new constraints on cosmological models with a varying $α$. We assume such a model where the electromagnetic sector is coupled to a scalar field dark energy responsible for the current acceleration of the Universe. We parametrise the variation of $α$ with two extra parameters, one defining the cosmological evolution of the quintessence component and the other fixing the coupling with the electromagnetic field. The objective of this work is to constrain these parameters with both astrophysical and local probes. We also carried out a comparative analysis of how each data probe may constrain our parametrisation. We performed a Bayesian analysis by comparing the predictions of the model with observations. The astrophysical datasets are composed of quasar spectra measurements, including the latest ESPRESSO data point, as well as Planck observations of the cosmic microwave background. We combined these with local results from atomic clocks and the MICROSCOPE experiment. The constraints placed on the quintessence parameter are consistent with a null variation of the field, and are therefore compatible with a $Λ$CDM cosmology. The constraints on the coupling to the electromagnetic sector are dominated by the Eötvös parameter local bound. More precise measurements with ESPRESSO will be extremely important to study the cosmological evolution of $α$ as it probes an interval of redshift not accessible to other types of observations. However, for this particular model, current available data favour a null variation of $α$ resulting mostly from the strong MICROSCOPE limits.
description: 9 pages, 7 figures, as published in A&A
Answers from the void: VIDE and its applications
Creators: name: Sutter, P. M.
name: Hamaus, N.
name: Pisani, A.
name: Lavaux, G.
name: Wandelt, B. D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We discuss various applications of VIDE, the Void IDentification and Examination toolkit, an open-source Python/C++ code for finding cosmic voids in galaxy redshift surveys and N-body simulations. Based on a substantially enhanced version of ZOBOV, VIDE not only finds voids, but also summarizes their properties, extracts statistical information, and provides a Python-based platform for more detailed analysis, such as manipulating void catalogs and particle members, filtering, plotting, computing clustering statistics, stacking, comparing catalogs, and fitting density profiles. VIDE also provides significant additional functionality for pre-processing inputs: for example, VIDE can work with volume- or magnitude-limited galaxy samples with arbitrary survey geometries, or dark matter particles or halo catalogs in a variety of common formats. It can also randomly subsample inputs and includes a Halo Occupation Distribution model for constructing mock galaxy populations. VIDE has been used for a wide variety of applications, from discovering a universal density profile to estimating primordial magnetic fields, and is publicly available at http://bitbucket.org/cosmicvoids/vide_public and http://www.cosmicvoids.net.
description: to appear as proceedings of the IAU Symposium 308 "The Zeldovich Universe, Genesis and Growth of the Cosmic Web"
Thermodynamic Stability at the Two-Particle Level
Creators: name: Kowalski, A.
name: Reitner, M.
name: Del Re, L.
name: Chatzieleftheriou, M.
name: Amaricci, A.
name: Toschi, A.
name: Medici, L. de'
name: Sangiovanni, G.
name: Schäfer, T.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We show how the stability conditions for a system of interacting fermions that conventionally involve variations of thermodynamic potentials can be rewritten in terms of one- and two-particle correlators. We illustrate the applicability of this alternative formulation in a multi-orbital model of strongly correlated electrons at finite temperatures, inspecting the lowest eigenvalues of the generalized local charge susceptibility in proximity of the phase-separation region. Additionally to the conventional unstable branches, we address unstable solutions possessing a positive, rather than negative compressibility. Our stability conditions require no derivative of free energy functions with conceptual and practical advantages for actual calculations and offer a clear-cut criterion for analyzing the thermodynamics of correlated complex systems.
description: 8+8 pages, 3+1 figures
Prostatic Acid Phosphatase Is Expressed in Peptidergic and Nonpeptidergic Nociceptive Neurons of Mice and Rats
Creators: name: Zylka, Mark J.
name: Taylor-Blake, Bonnie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Thiamine monophosphatase (TMPase, also known as Fluoride-resistant acid phosphatase or FRAP) is a classic histochemical marker of small- to medium-diameter dorsal root ganglia (DRG) neurons and has primarily been studied in the rat. Previously, we found that TMPase was molecularly identical to Prostatic acid phosphatase (PAP) using mice. In addition, PAP was expressed in a majority of nonpeptidergic, isolectin B4-binding (IB4+) nociceptive neurons and a subset of peptidergic, calcitonin gene-related peptide-containing (CGRP+) nociceptive neurons. At the time, we were unable to determine if PAP was present in rat DRG neurons because the antibody we used did not cross-react with PAP in rat tissues. In our present study, we generated a chicken polyclonal antibody against the secretory isoform of mouse PAP. This antibody detects mouse, rat and human PAP protein on western blots. Additionally, this antibody detects PAP in mouse and rat small- to medium-diameter DRG neurons and axon terminals in lamina II of spinal cord. In the rat, 92.5% of all PAP+ cells bind the nonpeptidergic marker IB4 and 31.8% of all PAP+ cells contain the peptidergic marker CGRP. Although PAP is found in peptidergic and nonpeptidergic neurons of mice and rats, the percentage of PAP+ neurons that express these markers differs between species. Moreover, PAP+ axon terminals in the rat partially overlap with Protein kinase Cγ (PKCγ+) interneurons in dorsal spinal cord whereas PAP+ axon terminals in the mouse terminate dorsal to PKCγ+ interneurons. Collectively, our studies highlight similarities and differences in PAP localization within nociceptive neurons of mice and rats.
Canadian Gallup Omnibus Poll # 111-1
Creators: name: Inc., The Canadian Gallup Poll
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Federal election vote intent(1); past federal elections(1); Canadian Senate(1); sexual harassment(2); language rights of Canadians(2); Parliament(2); Elizabeth Taylor(1); economic recession(1); federal government job performance(1); organs donation(2); Ontario provincial elections vote intent(1); Ontario Prime Minister job performance(1); economic outlook for 1992(6); satisfaction with Canada's progress(2); Brian Mulroney(2). Note: Standard demographics(18).
Additional file 1 of Circular RNA hsa_circ_0000915 promotes propranolol resistance of hemangioma stem cells in infantile haemangiomas
Creators: name: Chen, Hongrang
name: Li, Yongsheng
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Statistics
subject: FOS: Mathematics
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: 60506 Virology

description: Additional file 1. Oligomers used in the study.
Regulation of CCR5 Expression in Human Placenta: Insights from a Study of Mother-to-Child Transmission of HIV in Malawi
Creators: name: North, Kari E.
name: Franceschini, Nora
name: Mwapasa, Victor
name: Meshnick, Steven R.
name: Joubert, Bonnie R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: BackgroundHuman promoter polymorphisms in the chemokine co-receptor 5 gene (CCR5) have been noted for association with mother-to-child transmission of HIV (HIV MTCT) as well as reduced receptor expression in vitro, but have not been clearly associated with CCR5 expression in vivo. Placental expression of CCR5 may be influenced by such polymorphisms as well as other in vivo regulatory factors.Methodology/Principal FindingsWe evaluated the associations between infant CCR5 polymorphisms, measures of maternal infection, and placental expression of CCR5 among mother-infant pairs in Blantyre, Malawi. RNA was extracted from placental tissue and used in multiplex real-time PCR to quantify gene expression. Through linear regression, we observed that CCR5-2554T (β = −0.67, 95% CI = −1.23, −0.11) and -2132T (β = −0.75, 95% CI = −0.131, −0.18) were significantly associated with reduced placental expression of CCR5. An incremental increase in CCR5 expression was observed for incremental increases in expression of two heparan sulfate genes involved in viral infection, HS3ST3A1 (β = 0.27, 95% CI = 0.18, 0.35) and HS3ST3B1 (β = 0.11, 95% CI = 0.06, 0.18). Among HIV infected mothers, an incremental increase in maternal HIV viral load was also associated with higher CCR5 expression (β = 0.76, 95% CI = 0.12, 1.39). Maternal HIV status had no overall effect (β = 0.072, 95% CI = −0.57, −0.72). Higher CCR5 expression was observed for mothers with malaria but was not statistically significant (β = 0.37, 95% CI = −0.43, 1.18).Conclusions/SignificanceThese results provide in vivo evidence for genetic and environmental factors involved in the regulation of CCR5 expression in the placenta. Our findings also suggest that the measurement of placental expression of CCR5 alone is not an adequate indicator of the risk of mother-to-child transmission of HIV.
News from the isolated ellipticals NGC 5812, NGC 7507, and NGC 7796
Creators: name: Richtler, Tom
name: Salinas, Ricardo
name: Lane, Richard
name: Hilker, Michael
name: Caso, Juan Pablo
name: Bassino, Lilia P.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We report on ongoing photometric and spectroscopic work on a sample of isolated elliptical galaxies. We investigate their globular cluster systems, and use the kinematics of globular clusters and the integrated galaxy light to constrain their dark halos, which are not found in the cases of NGC 5812 and NGC 7507
description: 2 pages, highlight talk in the IAU symposium 309: Galaxies in 3D across the Universe, Vienna, 7-11 July 2014
Additional file 2 of Circular RNA hsa_circ_0000915 promotes propranolol resistance of hemangioma stem cells in infantile haemangiomas
Creators: name: Chen, Hongrang
name: Li, Yongsheng
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Statistics
subject: FOS: Mathematics
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: 60506 Virology

description: Additional file 2. Patient’s characteristics and response to propranolol.