cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Etiology of cardiac arrest in the absence of manifest structural heart disease : update from the CASPER prospective cohort.
Creators: name: Herman, Adam
Publisher: name: University of British Columbia
Year: 2015

description: Background: The Cardiac Arrest Survivors with Preserved Ejection Fraction Registry (CASPER) enrolls patients with apparently unexplained cardiac arrest and no evident cardiac disease, and aims to identify the underlying conditions responsible for the cardiac arrest through systematic clinical testing. A combination of exercise testing, drug provocation, electrophysiological testing, advanced cardiac imaging, and targeted genetic testing may unmask the cause of cardiac arrest when a cause is not apparent. Methods and Results: The first 200 survivors (48.6 ± 14.7 years, 41% female) of unexplained cardiac arrest from CASPER, from 14 centers across Canada were evaluated to determine the results of investigation and follow-up risk of recurrence. Patients were free of evidence of coronary artery disease, left ventricular dysfunction or evident repolarization syndromes. Advanced testing determined a probable or definite diagnosis in 41% of patients. During a median follow-up of 3.15±2.34 years, 23% of patients had either a shock from their ICD or appropriate anti-tachycardia pacing or both. The annual ICD appropriate intervention rate was 0.16 per year (SEM=0.14), with no clear difference in intervention rate between diagnosed and undiagnosed subjects, or between those diagnosed with a primary electrical versus structural etiology. Conclusions: Obtaining a diagnosis in previously unexplained cardiac arrest patients requires systematic clinical testing and regular follow-up to unmask the cause of cardiac arrest. Nearly half of apparent unexplained cardiac arrest patients ultimately received a diagnosis, allowing for improved treatment and family screening. A substantial proportion of patients received appropriate ICD therapy during follow-up.
Continuous variable quantum computation with spatial degrees of freedom of photons
Creators: name: Tasca, D. S.
name: Gomes, R. M.
name: Toscano, F.
name: Ribeiro, P. H. Souto
name: Walborn, S. P.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We discuss the use of the transverse spatial degrees of freedom of photons propagating in the paraxial approximation for continuous variable information processing. Given the wide variety of linear optical devices available, a diverse range of operations can be performed on the spatial degrees of freedom of single photons. Here we show how to implement a set of continuous quantum logic gates which allow for universal quantum computation. In contrast with the usual quadratures of the electromagnetic field, the entire set of single photon gates for spatial degrees of freedom does not require optical nonlinearity and, in principle, can be performed with a single device: the spatial light modulator. Nevertheless, nonlinear optical processes, such as four-wave mixing, are needed in the implementation of two-photon gates. The efficiency of these gates is at present very low, however small scale investigations of continuous variable quantum computation are within the reach of current technology. In this regard, we show how novel cluster states for one-way quantum computing can be produced using spontaneous parametric down conversion.
description: 11 pages, 6 figures
Inline determination of residence time distribution in hot-melt-extrusion
Creators: name: Wesholowski, Jens
name: Berghaus, Andreas
name: Thommes, Markus
Publisher: name: TU Dortmund
Year: 2018
Subjects: subject: UV/Vis spectroscopy
subject: Residence Time Distribution
subject: Twin screw extrusion
subject: Process analytical tool
subject: Quality-by-Design
subject: 660
subject: UV-VIS-Spektroskopie

description: In the framework of Quality-by-Design (QbD), the inline determination of process parameters or quality attributes of a product using sufficient process analytical technology (PAT) is a center piece for the establishment of continuous processes as a standard pharmaceutical technology. In this context, Twin-Screw-Extrusion (TSE) processes, such as Hot-Melt-Extrusion (HME), are one key aspect of current research. The main benefit of this process technology is the combination of different unit operations. Several of these sub-processes are linked to the Residence Time Distribution (RTD) of the material within the apparatus. In this study a UV/Vis spectrophotometer from ColVisTec was tested regarding the suitability for the inline determination of the RTD of an HME process. Two different measuring positions within a co-rotating Twin-Screw-Extruder were compared to an offline HPLC–UV as reference method. The obtained results were overall in good agreement and therefore the inline UV/Vis spectrophotometer is suitable for the determination of the RTD in TSE. An influence of the measuring position on repeatability was found and has to be taken into consideration for the implementation of PATs. An effect of the required amount of marker on process rheology is not likely due to the low Limit-of-Quantification (LoQ).
description: Pharmaceutics : Jg.: 10, Heft: 2 | S. 49-1-49-10;
Superconformal structures on generalized Calabi-Yau metric manifolds
Creators: name: Heluani, Reimundo
name: Zabzine, Maxim
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Algebra (math.QA)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We construct an embedding of two commuting copies of the N=2 superconformal vertex algebra in the space of global sections of the twisted chiral-anti-chiral de Rham complex of a generalized Calabi-Yau metric manifold, including the case when there is a non-trivial H-flux and non-vanishing dilaton. The 4 corresponding BRST charges are well defined on any generalized Kahler manifold. This allows one to consider the half-twisted model defining thus the chiral de Rham complex of a generalized Kahler manifold. The classical limit of this result allows one to recover the celebrated generalized Kahler identities as the degree zero part of an infinite dimensional Lie superalgebra attached to any generalized Kahler manifold. As a byproduct of our study we investigate the properties of generalized Calabi-Yau metric manifolds in the Lie algebroid setting.
description: 30 pp
Extracting cosmological signals from foregrounds in deep mm maps of the sky
Creators: name: Conversi, Luca
name: Fiadino, Paola
name: de Bernardis, Paolo
name: Masi, Silvia
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: The high Galactic latitude sky at millimeter and submm wavelengths contains significant cosmological information about the early Universe (in terms of the cosmic microwave background) but also the process of structure formation in the Universe from the far infrared background produced by early galaxies and the Sunyaev-Zeldovich effect in clusters of galaxies. As the Planck mission will produce full sky maps in this frequency range, deeper maps of selected low-foregrounds patches of the sky can produce complementary and important information. Here we analyze the performance of a balloon-borne survey covering a 10^\circ x 10^\circ patch of the sky with a few arcminute resolution and very high pixel sensitivity. We simulate the different components of the mm/submm sky (i.e., CMB anisotropies, SZ effect, radio and infrared sources, far infrared background, and interstellar dust) using current knowledge about each of them. We then combine them, adding detector noise, to produce detailed simulated observations in four observational bands ranging from 130 to 500 GHz. Finally, we analyze the simulated maps and estimate the performance of the instrument in extracting the relevant information about each of the components. We find that the CMB angular power spectrum is accurately recovered up to l ~ 3000. Using the Sunyaev-Zel'dovich effect, most of the galaxy clusters present in our input map are detected (60% efficiency overall). Our results also show that much stronger constrains can be placed on far infrared background models.
description: 10 pages, 8 figures, accepted for publication in A&A
The effects of synbiotic supplementation on serum inflammatory markers and edema volume in breast cancer survivors with lymphedema
Creators: name: Vafa, Saeideh
name: Haghighat, Shahpar
name: Janani, Leila
name: Totmaj, Ali Saneei
name: Navaei, Mehraban
name: Amirinejad, Ali
name: Emamat, Hadi
name: Salehi, Zahra
name: Zarrati, Mitra
Publisher: name: TU Dortmund
Year: 2020
Subjects: subject: Inflammation
subject: Breast cancer
subject: Lymphedema
subject: Probiotic
subject: Prebiotic
subject: Caloric restriction
subject: 610

description: Breast cancer-related lymphedema (BCRL) is one of the most common complications of breast cancer treatments, which may be exacerbated by obesity. Dysbiosis may negatively impact the management of obesity and lymphedema by increasing inflammation. The objective of this study was to assess the effects of supplementation with synbiotics on inflammatory markers, serum leptin concentration and edema volume in overweight and obese BCRL women following a low-calorie diet (LCD). In a randomized double-blind controlled clinical trial, 88 breast cancer survivors with lymphedema were supplemented once a day for 10 weeks with either a synbiotic or a placebo capsule. Both groups were under a low-calorie diet (LCD). At the end of the study, synbiotic supplementation resulted in a significant reduction in leptin (P=0.003) and TNF-α (P=0.039) between the study groups. Besides, edema volume was significantly reduced within the synbiotic group after the intervention. We did not observe any significant effects of the synbiotic supplementation in hs-CRP, and IL-1β between the study groups (P=0.550, P=0.118 respectively). Conclusively, synbiotic supplementation along with an LCD program in breast cancer survivors with lymphedema had beneficial effects on the concentration of serum inflammatory markers and edema volume.
description: EXCLI Journal;Vol.19.2020, p.1-15
Abelian symmetries in the two-Higgs-doublet model with fermions
Creators: name: Ferreira, P. M.
name: Silva, Joao P.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We classify all possible implementations of an abelian symmetry in the two-Higgs-doublet model with fermions. We identify those symmetries which are consistent with non-vanishing quark masses and a CKM matrix which is not block-diagonal. Our analysis takes us from a plethora of possibilities down to 246 relevant cases, requiring only 34 distinct matrix forms. We show that applying Z_n with n \geq 4 to the scalar sector leads to a continuous U(1) symmetry in the whole Lagrangian. Finally, we address the possibilities of spontaneous CP violation and of natural suppression of the flavour changing neutral currents. We explain why our work is relevant even for non-abelian symmetries.
description: 20 pages, RevTex
The impact of the Kasatochi eruption on the Moon's illumination during the August 2008 lunar eclipse
Creators: name: Muñoz, A. García
name: Pallé, E.
name: Osorio, M. R. Zapatero
name: Martín, E. L.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Geophysics (physics.geo-ph)
subject: FOS: Physical sciences

description: The Moon's changeable aspect during a lunar eclipse is largely attributable to variations in the refracted unscattered sunlight absorbed by the terrestrial atmosphere that occur as the satellite crosses the Earth's shadow. The contribution to the Moon's aspect from sunlight scattered at the Earth's terminator is generally deemed minor. However, our analysis of a published spectrum of the 16 August 2008 lunar eclipse shows that diffuse sunlight is a major component of the measured spectrum at wavelengths shorter than 600 nm. The conclusion is supported by two distinct features, namely the spectrum's tail at short wavelengths and the unequal absorption by an oxygen collisional complex at two nearby bands. Our findings are consistent with the presence of the volcanic cloud reported at high northern latitudes following the 7-8 August 2008 eruption in Alaska of the Kasatochi volcano. The cloud both attenuates the unscattered sunlight and enhances moderately the scattered component, thus modifying the contrast between the two contributions.
description: Accepted for publication in Geophysical Research Letters
title: Flirting with death: Traumatic aortic pseudoaneurysm in a street racer
Creators: name: Radhakrishnan, Jayakrishnan
Publisher: name: EURORAD
Year: 2021
Subjects: subject: Cardiovascular
subject: Arteries / Aorta
subject: CT-Angiography
subject: Acute
subject: Trauma
subject: Clinical Cases

description: Clinical History: A 24-year-old man presenting to the emergency department following a motorcycle accident.

description: 24 years, male
Neural Processes of Psychological Stress and Relaxation Predict the Future Evolution of Quality of Life in Multiple Sclerosis
Creators: name: Meyer-Arndt, Lil
name: Schmitz-Hübsch, Tanja
name: Bellmann-Strobl, Judith
name: Brandt, Alexander U.
name: Haynes, John-Dylan
name: Gold, Stefan M.
name: Paul, Friedemann
name: Weygandt, Martin
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: multiple sclerosis
subject: quality of life
subject: neuropsychiatric symptoms
subject: psychological stress
subject: functional magnet resonance imaging (fMRI)
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Health-related quality of life (HRQoL) is an essential complementary parameter in the assessment of disease burden and treatment outcome in multiple sclerosis (MS) and can be affected by neuropsychiatric symptoms, which in turn are sensitive to psychological stress. However, until now, the impact of neurobiological stress and relaxation on HRQoL in MS has not been investigated. We thus evaluated whether the activity of neural networks triggered by mild psychological stress (elicited in an fMRI task comprising mental arithmetic with feedback) or by stress termination (i.e., relaxation) at baseline (T0) predicts HRQoL variations occurring between T0 and a follow-up visit (T1) in 28 patients using a robust regression and permutation testing. The median delay between T0 and T1 was 902 (range: 363-1,169) days. We assessed HRQoL based on the Hamburg Quality of Life Questionnaire in MS (HAQUAMS) and accounted for the impact of established HRQoL predictors and the cognitive performance of the participants. Relaxation-triggered activity of a widespread neural network predicted future variations in overall HRQoL (t = 3.68, p(family-wise error [FWE])-corrected = 0.008). Complementary analyses showed that relaxation-triggered activity of the same network at baseline was associated with variations in the HAQUAMS mood subscale on an alpha(FWE) = 0.1 level (t = 3.37, p(FWE) = 0.087). Finally, stress-induced activity of a prefronto-limbic network predicted future variations in the HAQUAMS lower limb mobility subscale (t = -3.62, p(FWE) = 0.020). Functional neural network measures of psychological stress and relaxation contain prognostic information for future HRQoL evolution in MS independent of clinical predictors.
Don’t take a chance go see a doctor
Creators: name: (:Unav)
Publisher: name: Columbia University
Year: 2019
Subjects: Sexually transmitted diseases
Public health

description: "Glazer was taking part in an experiment by the Public Health Service, began in the late 1940s, called “VD Radio Project” (the “VD” was a nicer way of saying venereal disease). He wrote and performed this little song to introduce seven short announcements about venereal disease and the importance of getting seen by a doctor"--Sandy Rodriguez. Venereal Disease and Country Music, August 5, 2013
Case Report: Behavioral Disorder Following Hemispherotomy: A Valproate Effect?
Creators: name: Makridis, Konstantin L.
name: Triller, Sebastian
name: Atalay, Deniz A.
name: Prager, Christine
name: Elger, Christian E.
name: Kaindl, Angela M.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: drug resistant epilepsy
subject: pediatrics
subject: behavioral problems
subject: children
subject: valproic acid
subject: epilepsy surgery
subject: hemispherotomy
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Hemispherotomy is an epilepsy surgery procedure applied to cure particularly pharmacorefractory lesional epilepsy due to unihemispheric pathologies. Such a disconnection of an entire hemisphere is followed by reorganizational processes. Methods: We describe an acute aggravation of behavioral problems following a hemispherotomy in a patient treated with valproic acid, which subsided once valproate was discontinued. Results: A 9-year-old boy with drug-resistant epilepsy caused by the residua of a perinatal stroke treated for several years with valproic acid and lamotrigine underwent hemispherotomy. Shortly after surgery, minimal preoperative behavioral problems intensified dramatically, and aggression occurred as a new symptom. Assuming a correlation between valproate treatment and the postoperative altered neuronal network, we tapered off valproate. The behavioral problems decreased in intensity with the reduction of valproate dose and disappeared after drug discontinuation. Conclusion: We describe severe behavioral problems after hemispherotomy that subsided when valproate was tapered off. While we cannot rule out a spontaneous correction of a post-hemispherotomy network dysregulation, our report raises awareness to possible altered effects of the anticonvulsant valproic acid parallel to reorganizational processes after hemispherotomy.
Characterization of Solar Telescope Polarization Properties Across the Visible and Near-Infrared Spectrum. Case Study: The Dunn Solar Telescope
Creators: name: Socas-Navarro, Hector
name: Elmore, David
name: Ramos, Andres Asensio
Publisher: name: arXiv
Year: 2010
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Accurate astrophysical polarimetry requires a proper characterization of the polarization properties of the telescope and instrumentation employed to obtain the observations. Determining the telescope and instrument Muller matrix is becoming increasingly difficult with the increase in aperture size of the new and upcoming solar telescopes. We have carried out a detailed multi-wavelength characterization of the Dunn Solar Telescope (DST) at the National Solar Observatory/Sacramento Peak as a case study and explore various possibilites for the determination of its polarimetric properties. We show that the telescope model proposed in this paper is more suitable than that in previous work in that it describes better the wavelength dependence of aluminum-coated mirrors. We explore the adequacy of the degrees of freedom allowed by the model using a novel mathematical formalism. Finally, we investigate the use of polarimeter calibration data taken at different times of the day to characterize the telescope and find that very valuable information on the telescope properties can be obtained in this manner. The results are also consistent with the entrance window polarizer measurements, opening very interesting possibilities for the calibration of future large-aperture solar telescopes such as the ATST or the EST.
description: To be submitted to A&A (instrumentation section)
Three-Dimensional Iron Oxide Nanoparticle-Based Contrast-Enhanced Magnetic Resonance Imaging for Characterization of Cerebral Arteriogenesis in the Mouse Neocortex
Creators: name: De Bortoli, Till
name: Boehm-Sturm, Philipp
name: Koch, Stefan P.
name: Nieminen-Kelhä, Melina
name: Wessels, Lars
name: Mueller, Susanne
name: Ielacqua, Giovanna D.
name: Klohs, Jan
name: Vajkoczy, Peter
name: Hecht, Nils
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: contrast-enhanced MRI
subject: cerebral blood volume
subject: iron oxide nanoparticles
subject: stroke
subject: cerebrovascular disease
subject: vessel imaging
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose: Subsurface blood vessels in the cerebral cortex have been identified as a bottleneck in cerebral perfusion with the potential for collateral remodeling. However, valid techniques for non-invasive, longitudinal characterization of neocortical microvessels are still lacking. In this study, we validated contrast-enhanced magnetic resonance imaging (CE-MRI) for in vivo characterization of vascular changes in a model of spontaneous collateral outgrowth following chronic cerebral hypoperfusion. Methods: C57BL/6J mice were randomly assigned to unilateral internal carotid artery occlusion or sham surgery and after 21 days, CE-MRI based on T2*-weighted imaging was performed using ultra-small superparamagnetic iron oxide nanoparticles to obtain subtraction angiographies and steady-state cerebral blood volume (ss-CBV) maps. First pass dynamic susceptibility contrast MRI (DSC-MRI) was performed for internal validation of ss-CBV. Further validation at the histological level was provided by ex vivo serial two-photon tomography (STP). Results: Qualitatively, an increase in vessel density was observed on CE-MRI subtraction angiographies following occlusion; however, a quantitative vessel tracing analysis was prone to errors in our model. Measurements of ss-CBV reliably identified an increase in cortical vasculature, validated by DSC-MRI and STP. Conclusion: Iron oxide nanoparticle-based ss-CBV serves as a robust, non-invasive imaging surrogate marker for neocortical vessels, with the potential to reduce and refine preclinical models targeting the development and outgrowth of cerebral collateralization.
Perkaderan HMI dan Pendidikan Karakter: Potret dari HMI Cabang Gowa Raya
Creators: name: Wekke, Ismail Suardi
Publisher: name: Zenodo
Year: 2021
Subjects: himpunan mahasiswa islam
pembinaan anggota
perkaderan
canag gowa raya

description: Bedah Buku, Pengurus Besar Himpunan Mahasiswa Islam, Bidang Pembinaan Anggota, Selasa, 21 September 2021.
George Hicks interviews syphilis patients
Creators: name: (:Unav)
Publisher: name: Columbia University
Year: 2019
Subjects: Syphilis--Patients
Public health
Syphilis

description: "Part of V.D. Radio Project. In 1949, the American Public Health Service, in tandem with Columbia University, produced a number of programs aimed to stamp out syphilis."--WNYC
The impact of experiential training on group counsellor development
Creators: name: Hoover, Stuart Michael
Publisher: name: University of British Columbia
Year: 2015

description: To lead effective psychotherapy groups, counsellors must perform a complex array of skills with both confidence and competence. Best practices in training group counsellors advocate an integration of didactic and experiential learning (Barlow, 2012; CACREP, 2009). Experiential training is considered an invaluable training method for group counselling and has been shown to develop skill usage and understanding of group process in trainees (Stockton, Morran & Krieger, 2004). However, no study to date has experimentally examined the impact of experiential training on counsellor trainee development of confidence and competence. Therefore, this dissertation introduces an experiential training program seated in social cognitive theory and provides qualitative and quantitative evaluations of the impacts of the program on counsellor trainee confidence and competence variables.
A Birds-Eye (Re)View of Acid-Suppression Drugs, COVID-19, and the Highly Variable Literature
Creators: name: Mura, Cameron
name: Preissner, Saskia
name: Preissner, Robert
name: Bourne, Philip E.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: COVID-19
subject: histamine (H2) receptor
subject: famotidine
subject: knowledge graph
subject: disease ontology
subject: antagonist action
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: This Perspective examines a recent surge of information regarding the potential benefits of acid-suppression drugs in the context of COVID-19, with a particular eye on the great variability (and, thus, confusion) that has arisen across the reported findings, at least as regards the popular antacid famotidine. The degree of inconsistency and discordance reflects contradictory conclusions from independent, clinical-based studies that took roughly similar approaches, in terms of both experimental design (retrospective, observational, cohort-based, etc.) and statistical analysis workflows (propensity-score matching and stratification into sub-cohorts, etc.). The contradictions and potential confusion have ramifications for clinicians faced with choosing therapeutically optimal courses of intervention: e.g., do any potential benefits of famotidine suggest its use in a particular COVID-19 case? (If so, what administration route, dosage regimen, duration, etc. are likely optimal?) As succinctly put this March in Freedberg et al. (2021), "…several retrospective studies show relationships between famotidine and outcomes in COVID-19 and several do not." Beyond the pressing issue of possible therapeutic indications, the conflicting data and conclusions related to famotidine must be resolved before its inclusion/integration in ontological and knowledge graph (KG)-based frameworks, which in turn are useful for drug discovery and repurposing. As a broader methodological issue, note that reconciling inconsistencies would bolster the validity of meta-analyses which draw upon the relevant data-sources. And, perhaps most broadly, developing a system for treating inconsistencies would stand to improve the qualities of both 1) real world evidence-based studies (retrospective), on the one hand, and 2) placebo-controlled, randomized multi-center clinical trials (prospective), on the other hand. In other words, a systematic approach to reconciling the two types of studies would inherently improve the quality and utility of each type of study individually.
Development of novel salicylic acid–donepezil–rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer’s disease
Creators: name: Zhou, Yi
name: He, Ying
name: Teng, Xue
name: Mi, Jing
name: Yang, Jing
name: Wei, Rongrui
name: Liu, Wenmin
name: Ma, Qinge
name: Tan, Zhenghuai
name: Sang, Zhipei
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Information Systems not elsewhere classified
subject: Mental Health
subject: Hematology

description: Alzheimer’s disease (AD) is a chronic, progressive brain degenerative disease that is common in the elderly. So far, there is no effective treatment. The multi-target-directed ligands (MTDLs) strategy has been recognised as the most promising approach due to the complexity of the pathogenesis of AD. Herein, novel salicylic acid–donepezil–rivastigmine hybrids were designed and synthesised. The bioactivity results exhibited that 5a was a reversible and selective eqBChE inhibitor (IC50 = 0.53 μM), and the docking provided the possible mechanism. Compound 5a also displayed potential anti-inflammatory effects and significant neuroprotective effect. Moreover, 5a exhibited favourable stabilities in artificial gastrointestinal solution and plasma. Finally, 5a demonstrated potential cognitive improvement in scopolamine-induced cognitive dysfunction. Hence, 5a was a potential multifunctional lead compound against AD.
Unconventional modes in lasers with spatially varying gain and loss
Creators: name: Ge, Li
name: Chong, Y. D.
name: Rotter, S.
name: Türeci, H. E.
name: Stone, A. D.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We discuss a class of lasing modes created by a spatially inhomogeneous gain profile. These lasing modes are "extra modes", in addition to, and very different from, conventional lasing modes, which arise from the passive cavity resonances. These new modes do not have high intensity across the entire gain region, but instead are localized at the gain boundary and throughout the gain-free region. They are surface modes, originating from the transmission resonances of the gain-free region. Using an S-matrix description we connect these surface modes to the lasing modes in PT-symmetric (balanced gain-loss) cavities.
description: 8 pages, 7 figures
Topological Anderson Insulator in Three Dimensions
Creators: name: Guo, H. -M.
name: Rosenberg, G.
name: Refael, G.
name: Franz, M.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Disorder, ubiquitously present in solids, is normally detrimental to the stability of ordered states of matter. In this letter we demonstrate that not only is the physics of a strong topological insulator robust to disorder but, remarkably, under certain conditions disorder can become fundamentally responsible for its existence. We show that disorder, when sufficiently strong, can transform an ordinary metal with strong spin-orbit coupling into a strong topological `Anderson' insulator, a new topological phase of quantum matter in three dimensions.
description: 5 pages, 2 figures. For related work and info visit http://www.physics.ubc.ca/~franz/
Extracellular Matrix Protein Ratios in the Human Heart and Vessels: How to Distinguish Pathological From Physiological Changes?
Creators: name: Wittig, Corey
name: Szulcek, Robert
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: cardiovascular
subject: elastin
subject: human
subject: extracellular matrix
subject: pathology
subject: heart
subject: aorta
subject: collagen
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Cardiovascular pathology is often accompanied by changes in relative content and/or ratios of structural extracellular matrix (ECM) proteins within the heart and elastic vessels. Three of these proteins, collagen-I, collagen-III, and elastin, make up the bulk of the ECM proteins in these tissues, forming a microenvironment that strongly dictates the tissue biomechanical properties and effectiveness of cardiac and vascular function. In this review, we aim to elucidate how the ratios of collagen-I to collagen-III and elastin to collagen are altered in cardiovascular diseases and the aged individuum. We elaborate on these major cardiovascular ECM proteins in terms of structure, tissue localization, turnover, and physiological function and address how their ratios change in aging, dilated cardiomyopathy, coronary artery disease with myocardial infarction, atrial fibrillation, aortic aneurysms, atherosclerosis, and hypertension. To the end of guiding in vitro modeling approaches, we focus our review on the human heart and aorta, discuss limitations in ECM protein quantification methodology, examine comparability between studies, and highlight potential in vitro applications. In summary, we found collagen-I relative concentration to increase or stay the same in cardiovascular disease, resulting in a tendency for increased collagen-I/collagen-III and decreased elastin/collagen ratios. These ratios were found to fall on a continuous scale with ranges defining distinct pathological states as well as a significant difference between the human heart and aortic ECM protein ratios.
Experimental generation and characterization of single-photon hybrid ququarts based on polarization-orbital angular momentum encoding
Creators: name: Nagali, Eleonora
name: Sansoni, Linda
name: Marrucci, Lorenzo
name: Santamato, Enrico
name: Sciarrino, Fabio
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Physics (quant-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: High-dimensional quantum states, or qudits, represent a promising resource in the quantum information field. Here we present the experimental generation of four-dimensional quantum states, or ququarts, encoded in the polarization and orbital angular momentum of a single photon. Our novel technique, based on the q-plate device, allows to prepare and measure the ququart in all five mutually unbiased bases. We report the reconstruction of the four dimensional density matrix through the tomographic procedure for different ququart states.
description: 7 pages, 5 figures
RNase A Inhibits Formation of Neutrophil Extracellular Traps in Subarachnoid Hemorrhage
Creators: name: Früh, Anton
name: Tielking, Katharina
name: Schoknecht, Felix
name: Liu, Shuheng
name: Schneider, Ulf C.
name: Fischer, Silvia
name: Vajkoczy, Peter
name: Xu, Ran
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: neutrophil extracellular traps
subject: neutrophils
subject: subarachnoid hemorrhage
subject: hemorrhagic stroke
subject: neuroinflammation
subject: innate immune response
subject: innate immune reaction
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Subarachnoid hemorrhage (SAH) caused by rupture of an intracranial aneurysm, is a life-threatening emergency that is associated with substantial morbidity and mortality. Emerging evidence suggests involvement of the innate immune response in secondary brain injury, and a potential role of neutrophil extracellular traps (NETs) for SAH-associated neuroinflammation. In this study, we investigated the spatiotemporal patterns of NETs in SAH and the potential role of the RNase A (the bovine equivalent to human RNase 1) application on NET burden. Methods: A total number of n=81 male C57Bl/6 mice were operated utilizing a filament perforation model to induce SAH, and Sham operation was performed for the corresponding control groups. To confirm the bleeding and exclude stroke and intracerebral hemorrhage, the animals received MRI after 24h. Mice were treated with intravenous injection of RNase A (42 mu g/kg body weight) or saline solution for the control groups, respectively. Quadruple-immunofluorescence (IF) staining for cell nuclei (DAPI), F-actin (phalloidin), citrullinated H3, and neurons (NeuN) was analyzed by confocal imaging and used to quantify NET abundance in the subarachnoid space (SAS) and brain parenchyma. To quantify NETs in human SAH patients, cerebrospinal spinal fluid (CSF) and blood samples from day 1, 2, 7, and 14 after bleeding onset were analyzed for double-stranded DNA (dsDNA) via Sytox Green. Results: Neutrophil extracellular traps are released upon subarachnoid hemorrhage in the SAS on the ipsilateral bleeding site 24h after ictus. Over time, NETs showed progressive increase in the parenchyma on both ipsi- and contralateral site, peaking on day 14 in periventricular localization. In CSF and blood samples of patients with aneurysmal SAH, NETs also increased gradually over time with a peak on day 7. RNase application significantly reduced NET accumulation in basal, cortical, and periventricular areas. Conclusion: Neutrophil extracellular trap formation following SAH originates in the ipsilateral SAS of the bleeding site and spreads gradually over time to basal, cortical, and periventricular areas in the parenchyma within 14days. Intravenous RNase application abrogates NET burden significantly in the brain parenchyma, underpinning a potential role in modulation of the innate immune activation after SAH.
Tracking the precession of compact binaries from their gravitational-wave signal
Creators: name: Schmidt, Patricia
name: Hannam, Mark
name: Husa, Sascha
name: Ajith, P.
Publisher: name: arXiv
Year: 2010
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We present a simple method to track the precession of a black-hole-binary system, using only information from the gravitational-wave (GW) signal. Our method consists of locating the frame from which the magnitude of the $(\ell=2,|m|=2)$ modes is maximized, which we denote the "quadrupole-aligned" frame. We demonstrate the efficacy of this method when applied to waveforms from numerical simulations. In the test case of an equal-mass nonspinning binary, our method locates the direction of the orbital angular momentum to within $(Δθ, Δϕ) = (0.05^{\circ},0.2^{\circ})$. We then apply the method to a $q = M_2/M_1 = 3$ binary that exhibits significant precession. In general a spinning binary's orbital angular momentum $\mathbf{L}$ is \emph{not} orthogonal to the orbital plane. Evidence that our method locates the direction of $\mathbf{L}$ rather than the normal of the orbital plane is provided by comparison with post-Newtonian (PN) results. Also, we observe that it accurately reproduces similar higher-mode amplitudes to a comparable non-spinning (and therefore non-precessing) binary, and that the frequency of the $(\ell=2,|m|=2)$ modes is consistent with the "total frequency" of the binary's motion. The simple form of the quadrupole-aligned waveform will be useful in attempts to analytically model the inspiral-merger-ringdown (IMR) signal of precessing binaries, and in standardizing the representation of waveforms for studies of accuracy and consistency of source modelling efforts, both numerical and analytical.
description: 11 pages, 12 figures, 1 table
Multiple Ionization Bursts in Laser-Driven Hydrogen Molecular Ion
Creators: name: Takemoto, Norio
name: Becker, Andreas
Publisher: name: arXiv
Year: 2010
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: Theoretical study on H$_2^+$ in an intense infrared laser field on the attosecond time-scale reveals that the molecular ion shows multiple bursts of ionization within a half-cycle of the laser field oscillation, in contrast to the widely accepted tunnel ionization picture for an atom. These bursts are found to be induced by transient localization of the electron at one of the nuclei, and a relation between the time instants of the localization and the vector potential of the laser light is derived. Furthermore, an experimental scheme is proposed to probe the localization dynamics by an extreme ultraviolet laser pulse.
description: 5 pages, 4 figures
Measurement of the t-channel single top quark production cross section in pp collisions at sqrt(s) = 7 TeV
Creators: name: CMS Collaboration
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Electroweak production of the top quark is measured in pp collisions at sqrt(s) = 7 TeV, using a dataset collected with the CMS detector at the LHC and corresponding to an integrated luminosity of 36 inverse picobarns. With an event selection optimized for t-channel production, two complementary analyses are performed. The first one exploits the special angular properties of the signal, together with background estimates from data. The second approach uses a multivariate analysis technique to probe the compatibility with signal topology expected from electroweak top quark production. The combined measurement of the cross section is 83.6 +/- 29.8 (stat.+syst.) +/- 3.3 (lumi.) pb, consistent with the standard model expectation.
Dicksein
Creators: name: Lyssy, Deborah
Publisher: name: Fachhochschule Nordwestschweiz FHNW - Hochschule für Soziale Arbeit
Year: 2023
Subjects: Dick
kritischer Blick
Adipositas

description: Dicksein wird gesellschaftlich als grosses Problem bezeichnet. Die Medikalisierung des idealen Körpergewichts hat mitunter dazu beigetragen, dass mit hohem Körpergewicht Angst vor Krankheit und hohem Mortalitätsrisiko einhergehen. Um die Mythen um Dicksein aufzudecken und zu durchbrechen, muss einerseits die medizinische Diskussion um Dicksein kritisch beleuchtet werden und andererseits ein gesellschaftliches Umdenken stattfinden. Vorliegend wird aufgezeigt, wie dicke Menschen aufgrund vorherrschender Vorurteile stigmatisiert werden. Anhand feministischer Theorien und Fat Studies wird das Erleben dicker Menschen ins Zentrum gerückt und gesellschaftliche Strukturen, die zur Stigmatisierung führen, in Frage gestellt. Dazu hat sich die Frage gestellt, wie das Thema Dicksein und Diskriminierung dicker Menschen in der Sozialen Arbeit thematisiert wird. Eine Umfrage an den Schweizerischen Fachhochschulen hat gezeigt, dass Fat Studies und die Diskriminierung dicker Menschen im Rahmen des Bachelor-Studiums in Sozialer Arbeit keine grosse Rolle einnehmen. Vorliegend werden Gedankenanstösse dazu gegeben, wie und weshalb Fat Studies im Bachelor-Studium in Sozialer Arbeit eine zentralere Rolle einnehmen sollten.
Individually tunable tunnelling coefficients in optical lattices using local periodic driving
Creators: name: Nixon, Georgia M.
name: Unal, F. Nur
name: Schneider, Ulrich
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Atomic Physics (physics.atom-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Ultracold atoms in optical lattices have emerged as powerful quantum simulators of translationally invariant systems with many applications in e.g.\ strongly-correlated and topological systems. However, the ability to locally tune all Hamiltonian parameters remains an outstanding goal that would enable the simulation of a wider range of quantum phenomena. Motivated by recent advances in quantum gas microscopes and optical tweezers, we here show theoretically how local control over individual tunnelling links in an optical lattice can be achieved by incorporating local time-periodic potentials. We propose to periodically modulate the on-site energy of individual lattice sites and employ Floquet theory to demonstrate how this provides full individual control over the tunnelling amplitudes in one dimension. We provide various example configurations realising interesting topological models such as extended Su-Schrieffer-Heeger models that would be challenging to realise by other means. Extending to two dimensions, we demonstrate that local periodic driving in a Lieb lattice engineers a 2D network with fully controllable tunnelling magnitudes. In a three-site plaquette, we show full simultaneous control over the relative tunnelling amplitudes and the gauge-invariant flux piercing the plaquette, providing a clear stepping stone to building a fully programmable 2D tight-binding model. We also explicitly demonstrate how utilise our technique to generate a magnetic field gradient in 2D. This local modulation scheme is applicable to many different lattice geometries.
description: 17 pages, 14 figures
Unterstützte Kommunikation
Creators: name: Fischer, Lisa Mo
Publisher: name: Fachhochschule Nordwestschweiz FHNW - Hochschule für Soziale Arbeit
Year: 2023
Subjects: Heilmethode
Kommunikation
UK

description: Die vorliegende Bachelorarbeit befasst sich mit dem Konzept der Unterstützten Kommunikation «UK». Für die Bearbeitung der Hauptfragestellung wird in einem ersten Teil der Arbeit eine theoretische Verortung dieses Konzepts vorgenommen. Dies geschieht anhand von drei Theorien der Kommunikation, entlang der UN-Behindertenrechtskonvention, des Berufskodex AvenirSocial sowie dem Konzept der Funktionalen Gesundheit. Im Sinne der Behandlung der ersten Unterfragestellung wird aufgezeigt, dass sich aus der theoretischen Verortung der Unterstützten Kommunikation eine klare Handlungsaufforderung an die Soziale Arbeit ableiten lässt. Darauf aufbauend werden das Konzept der Unterstützten Kommunikation, dessen Zielsetzung sowie konkrete lautsprach-ergänzende und -ersetzende Kommunikationshilfen der UK erläutert. Es wird gezeigt, wie verschiedene Hilfsmittel der Unterstützten Kommunikation dazu beitragen können, die Partizipation von Menschen mit Beeinträchtigungen zu unterstützen und zu fördern. Dies wird anhand eines Praxisbeispiels veranschaulicht. Letztlich wird im Zuge der Bearbeitung der zweiten Unterfragestellung dargestellt, woraus sich die Notwendigkeit einer institutionellen Verankerung der Unterstützten Kommunikation ergibt, und wie UK konkret in sozialen Institutionen implementiert werden kann.
Überschuldung
Creators: name: Renz, Iris
Publisher: name: Fachhochschule Nordwestschweiz FHNW - Hochschule für Soziale Arbeit
Year: 2023
Subjects: Schweiz
Soziale Arbeit
Überschuldung
Handlungsoptionen

description: Diese Arbeit befasst sich mit der Frage nach einer Beschreibung der Lebenslage von überschuldeten Personen und der Frage nach Handlungsoptionen für die Soziale Arbeit. Die Lebenslage wird anhand des Modells «Dimensionen Sozialer Ungleichheit» dargestellt. Diese Dimensionen umfassen die ökonomische, wohlfahrtsstaatliche und soziale Ebene. Bei den Handlungsoptionen für die Soziale Arbeit werden aus dem Berufskodex vier Handlungsebenen abgeleitet und festgehalten, wie sich Soziale Arbeit innerhalb dieser Ebenen für ihre Klientel einsetzt. Es kann festgestellt werden, dass überschuldete Personen in mehreren Teufelskreisen gefangen sind. Diese Teufelskreise werden vom Gesetz aufrechterhalten, womit erst durch eine oder mehrere Gesetzesänderungen Perspektive auf Schuldenfreiheit für überschuldete Menschen besteht. Es werden an diesem Punkt zwei geforderte Änderungen besprochen, zum einen ein Restschuldbefreiungsverfahren, zum anderen ein freiwilliger Steuerabzug und Abzug der Krankenkassenprämien direkt vom Lohn.
Low Temperature Specific Heat of Optimally Doped BaFe$_{2-x}$$TM_x$As$_{2}$ ($TM$ = Co and Ni) Single Crystals: Constraint on the Pairing Gap
Creators: name: Zeng, Bin
name: Mu, Gang
name: Shen, Bing
name: Cheng, Peng
name: Luo, Huiqian
name: Yang, Huan
name: Shan, Lei
name: Ren, Cong
name: Wen, Hai-Hu
Publisher: name: arXiv
Year: 2010
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Low temperature specific heat has been measured in optimally doped and highly overdoped non-superconducting BaFe$_{2-x}$TM$_x$As$_{2}$ ($TM$ = Co and Ni) single crystals. By using the data of the overdoped samples, we successfully removed the phonon contribution of the optimally doped ones, and derived the electronic specific heat coefficient $γ_e$. Remarkably, we found a continuing temperature dependent $γ_e(T)$ which follows the quadratic relation $γ_e=γ_0+αT^2$ in the low temperature limit. Together with the very small residual term $γ_0$, linear magnetic field dependence of $γ_e$, it is concluded that there are either small segments of nodal lines, or point-like nodes in these samples.
description: 5 pages, 5 figures