cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Beyond protein factories : expanding the synthetic biology toolkit for engineering mammalian hosts
Creators: name: Cheng, Joseph Kit
name: 0000-0002-5150-4984
Publisher: name: The University of Texas at Austin
Year: 2017
Subjects: Mammalian cell engineering
Promoter engineering
Terminator engineering

description: The incredible clinical and commercial successes of recombinant protein therapeutics cemented the use of mammalian cells as the premier production hosts for these products. However, we can further exploit these cells to harness their potential for addressing current and future medical needs through metabolic and advanced engineering of these cells. To do so, we need a deeper understanding of the intricate gene regulation network that governs these cells and the ability to attain precise control of gene expression levels. In addition, some of these applications, such as gene therapy and immunotherapy, could benefit greatly by refraining from using viral-derived genetic elements. Therefore, this work seeks to establish additional transcriptional control elements to improve our ability to regulate expression with generalizable approaches and methods, facilitating the adaptation of these techniques for any mammalian cell type of interest. Here, we successfully demonstrated three key genetic elements can be utilized to tune gene expression in a rational manner. First, we conducted a genome-wide screen to survey genomic integration sites that support high transcriptional activity. We showed that CRISPR/Cas9-mediated de novo integration into one of these transcriptional hot-spots at the GRIK1 locus resulted in a 2.4-fold increase in heterologous gene expression over random integration. Subsequently, we set the groundwork necessary to evaluate a cell line development strategy that aims to increase the frequency of successful de novo targeted integrations. Second, we utilized two approaches for rational promoter engineering. We established a transcriptomics-guided workflow for de novo synthetic promoter design based on the Design-Build-Test paradigm. By using this workflow, we generated two synthetic designs that were comparable to a strong viral promoter and a strong endogenous promoter. We also employed an alternative approach by creating hybrid promoters, which resulted in a hybrid promoter variant that was also comparable to the same viral and endogenous promoters. Third, we exploited the general mammalian terminator structure and created a synthetic terminator that was comparable to a strong viral terminator. We evaluated 12 endogenous and 30 synthetic terminators for heterologous gene expression and revealed interactions between several key components of the terminator. Critically, we showed that transgene expression was 1.9x higher with endogenous and synthetic elements when compared with strong viral-derived elements. Ultimately, we showed that transgene expression can be finely adjusted by the approaches and methods described in this dissertation, and that viral-derived elements can be readily substituted by our synthetic designs.
PARÁMETROS DE LA CALIDAD DEL HUEVO Y LAS FORMAS COMERCIALES EN EL DISTRITO DE MIRAFLORES, PERIODO 2009
Creators: name: Shiroma, Patricia
Publisher: name: figshare
Year: 2016
Subjects: Medicine

description:   This work of investigation was realized with the aim of determining the relation that exists between the parameters of quality of the egg with the commercial forms in the district of Miraflores in period 2009. Because of that, it was used a card of data collection with the parameters of quality established by the guides and norms of commercialization of the hen egg. 382 eggs were distributed in two groups: group A (traditional commerce) and group B (commerce in supermarket regime) to be evaluated. Therefore, 186 eggs came from traditional commerce (store, points of sale of the supply market and bioferia) and 186 of the commerce in supermarket regime (supermarket, supermarket specialized and mini supermarket). Of the results, a smaller percentage of eggs was observed than they fulfilled the parameters of external quality (44), packaged (16,70) in group A with respect to the group B, in what a 100% of eggs are commercialize packaging and 81,20 % fulfill the parameters of external quality. On the other hand, group A commercialize a smaller percentage (39,80) of eggs stored between 7 and 12, with respect to group B (86,6). Despite a percentage of high breach (95,16%) as far as the parameters of internal quality in both groups exists, Therefore, it was observed significant differences (p<0,05) Therefore, it was observed significant differences as far as the parameters of external quality, packaging and freshness of eggs between both groups. Then, the traditional commerce does not carry out a quality control of eggs received before being commercialized the consumer.
Asymptotics for the number of directions determined by $[n] \times [n]$ in $\mathbb{F}_p^2$
Creators: name: Martin, Greg
name: White, Ethan Patrick
name: Yip, Chi Hoi
Publisher: name: arXiv
Year: 2021
Subjects: subject: Number Theory (math.NT)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 11D45, 11D09, 11B30, 11L05

description: Let $p$ be a prime and $n$ a positive integer such that $\sqrt{\frac p2} + 1 \leq n \leq \sqrt{p}$. For any arithmetic progression $A$ of length $n$ in $\mathbb{F}_p$, we establish an asymptotic formula for the number of directions determined by $A \times A \subset \mathbb{F}_p^2$. The key idea is to reduce the problem to counting the number of solutions to the bilinear Diophantine equation $ad+bc=p$ in variables $1\le a,b,c,d\le n$; our asymptotic formula for the number of solutions is of independent interest.
description: 22 pages, 1 figure
title: Colección general de las providencias hasta aquí tomadas por el gobierno... de los regulares de la Compañía... de España, Indias e islas Filipinas
Creators: name: Anonyme
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: 4°
description: Reliure
description: Source: Bibliothèque patrimoniale Villon (Rouen), fonds Liber, Mt m 20546
Additional file 1 of Harm of circadian misalignment to the hearts of the adolescent wistar rats
Creators: name: Wang, YunLei
name: Hou, YuanYuan
name: Song, ShaoFei
name: Zuo, Yao
name: Yu, Yan
name: Chi, YaFei
name: Zhang, Tong
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Mental Health

description: Additional file 1: Figure S1. (A) The time list of this experiment. (B) The photoperiod of the two groups of rats. (C) The measurement items and number distribution of the two parts rats
Win-Win: Embedding Future Librarians to Extend Service to Online Classes
Creators: name: Peters, Timothy
name: LaDell-Thomas, Julie
Publisher: name: figshare
Year: 2016
Subjects: subject: 80706 Librarianship
subject: FOS: Media and communications
subject: Library and Information Studies
subject: 80799 Library and Information Studies not elsewhere classified

description: This paper (which appears as a chapter in the book Virtually Embedded: The Librarian in an Online Environment, c 2014) details the Central Michigan University Libraries' experiences with embedding library school graduate students from San Jose State University into CMU graduate classes. The graduate students were trained, mentored, and supervised by CMU librarians as they served as embedded librarians for a semester. The experience allowed the CMU Libraries to extend its reach into online classes and the SJSU students to gain valuable professional experience.
Additional file 3 of Harm of circadian misalignment to the hearts of the adolescent wistar rats
Creators: name: Wang, YunLei
name: Hou, YuanYuan
name: Song, ShaoFei
name: Zuo, Yao
name: Yu, Yan
name: Chi, YaFei
name: Zhang, Tong
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Mental Health

description: Additional file 3: Experimental methods.
Behavioral and multiomics analysis of three-dimensional clinostat simulated microgravity effect in mice
Creators: name: 周澧(Li Zhou)
Publisher: name: CNGB
Year: 2024
Subjects: Raw sequence reads
Transcriptome or Gene expression
Metabolome
Multiisolate
Medical

description: Eighteen male 10-week-old C57BL/6J mice were randomized into three groups: mice in ordinary cages group (MC, n = 6), survival box for clinostat group (SB, n = 6), and clinostat + survival box group (CS, n = 6). Behavioral experiments (including grip strength experiment, open field test, novel object recognition test, Y Maze, elevated plus maze, tail suspension test, gait analysis, rotarod test, Morris water maze, forced swim test and fear conditioning test), femur micro-CT, brain transcriptomics, serum metabolomics and fecal microbiomics were conducted to evaluate the impact of 3D clinostat simulated microgravity effect.
Radiation from Einstein-Gauss-Bonnet de Sitter Black Hole via Tunneling Process
Creators: name: Eslamzadeh, Sareh
name: Firouzjaee, Javad T.
name: Nozari, Kourosh
Publisher: name: arXiv
Year: 2021
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this paper, we probe in 4D Einstein-Gauss-Bonnet black hole and its thermodynamics. We illustrate the three asymptotically 4D EGB spacetime as an asymptotically flat, de Sitter, and Anti-de Sitter. Also, we apply the tunneling of the massless particles from the horizon of 4D EGB gravity and we investigate the correlation between the emission modes and temperature of the horizon. In asymptotically flat spacetime, the existence of the coupling constant alone constructs the regular spacetime, the radiation deviates from the pure thermal, and the temperature of the black hole horizon would be zero in the final stage of the black hole evaporation. In Asymptotically de Sitter spacetime, results illustrate that the evolution of the temperatures is in direction of the remaining rest mass with the probably same temperature for the black hole and the cosmological horizon. In addition, the exciting result is that temperature behaviors exactly match with the temperature behaviors of a regular black hole in Lovelock gravity in a higher dimension.
description: 8 figures
title: Neither philosophy nor literature
title: the poetic truth condition
titleType: Subtitle
Creators: name: Purvis, Doug
Publisher: name: Lancaster University
Year: 2020
Subjects: subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: poetry
subject: Literature

description: This work is conceived as an antiphilosophical riposte to Alain Badiou’s ‘return of philosophy itself’ thesis, taking as its inspiration Wittgenstein’s gnomic notebook entry of the 1930s to the effect that philosophy ‘ought now to be written only as one would write poetry’. Badiou wants philosophy to be as pure as mathematics, but this only sees it distilled down to an essence whereby nothing of itself remains. In ‘fleshing out’ its ideas as living, breathing metaphors, on the other hand, transcending its habitual tautologies and pseudo-problems, it supersedes itself; it becomes figurative, which is to say poetic, and no longer contained by discursive limits. My argument unfolds through considerations of a series of key metaphors, considering the inherent Narcissism that leads Badiou to read his philosophy of the event into the works of Mallarmé and Celan. I counter his forensic, flattened, monosemic explications with ambisemic re-readings. Poetic motifs are re-interpreted in a context of synaesthetic re-awakenings rather than ‘truths,’ emphasizing a hermeneutic of the ‘perhaps,’ and contingent encounters in which communication precedes and supersedes rational understanding.
Test MM Type B by DHAI (Project) (2021) | Type-B (ID n° 476)
Creators: name: DHAI, Project
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021
Subjects: Astronomy
History of astronomy
DISHAS
Astronomical table

description: This is a type B edition: A type-B edition corresponds to a critical edition of several table witnesses:
 it is based on several different editions, themselves based on tables from different primary sources.
 A type-B edition can be based on type-A, type-B or type-C editions.
You can find it on the DISHAS project website from this link: https://dishas.obspm.fr/table-edition/476
Structural Design Recommendations in the Early Design Phase using Machine Learning
Creators: name: Ampanavos, Spyridon
name: Nourbakhsh, Mehdi
name: Cheng, Chin-Yi
Publisher: name: arXiv
Year: 2021
Subjects: subject: Machine Learning (cs.LG)
subject: Computational Engineering, Finance, and Science (cs.CE)
subject: FOS: Computer and information sciences

description: Structural engineering knowledge can be of significant importance to the architectural design team during the early design phase. However, architects and engineers do not typically work together during the conceptual phase; in fact, structural engineers are often called late into the process. As a result, updates in the design are more difficult and time-consuming to complete. At the same time, there is a lost opportunity for better design exploration guided by structural feedback. In general, the earlier in the design process the iteration happens, the greater the benefits in cost efficiency and informed de-sign exploration, which can lead to higher-quality creative results. In order to facilitate an informed exploration in the early design stage, we suggest the automation of fundamental structural engineering tasks and introduce ApproxiFramer, a Machine Learning-based system for the automatic generation of structural layouts from building plan sketches in real-time. The system aims to assist architects by presenting them with feasible structural solutions during the conceptual phase so that they proceed with their design with adequate knowledge of its structural implications. In this paper, we describe the system and evaluate the performance of a proof-of-concept implementation in the domain of orthogonal, metal, rigid structures. We trained a Convolutional Neural Net to iteratively generate structural design solutions for sketch-level building plans using a synthetic dataset and achieved an average error of 2.2% in the predicted positions of the columns.
description: CAAD Futures 2021
A rare case of an androgen-producing stromal luteoma of the ovary in a postmenopausal woman, diagnosed by means of selective venous blood sampling
Creators: name: Bogdanou, Dimitra
name: Meyer, Gesine
name: Anja-Undine Stuecker
name: Thalhammer, Axel
name: Martin-Leo Hansmann
name: Joerg Bojunga
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Inorganic Chemistry
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: A rare case of an androgen-producing stromal luteoma of the ovary in a postmenopausal woman, diagnosed by means of selective venous blood sampling
Additional file 2 of Harm of circadian misalignment to the hearts of the adolescent wistar rats
Creators: name: Wang, YunLei
name: Hou, YuanYuan
name: Song, ShaoFei
name: Zuo, Yao
name: Yu, Yan
name: Chi, YaFei
name: Zhang, Tong
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Mental Health

description: Additional file 2: Figure S2. Summary of the findings in this study
Early-Phase Performance-Driven Design using Generative Models
Creators: name: Ampanavos, Spyridon
name: Malkawi, Ali
Publisher: name: arXiv
Year: 2021
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Current performance-driven building design methods are not widely adopted outside the research field for several reasons that make them difficult to integrate into a typical design process. In the early design phase, in particular, the time-intensity and the cognitive load associated with optimization and form parametrization are incompatible with design exploration, which requires quick iteration. This research introduces a novel method for performance-driven geometry generation that can afford interaction directly in the 3d modeling environment, eliminating the need for explicit parametrization, and is multiple orders faster than the equivalent form optimization. The method uses Machine Learning techniques to train a generative model offline. The generative model learns a distribution of optimal performing geometries and their simulation contexts based on a dataset that addresses the performance(s) of interest. By navigating the generative model's latent space, geometries with the desired characteristics can be quickly generated. A case study is presented, demonstrating the generation of a synthetic dataset and the use of a Variational Autoencoder (VAE) as a generative model for geometries with optimal solar gain. The results show that the VAE-generated geometries perform on average at least as well as the optimized ones, suggesting that the introduced method shows a feasible path towards more intuitive and interactive early-phase performance-driven design assistance.
description: CAAD Futures 2021
A cubic ring of integers with the smallest Pythagoras number
Creators: name: Krásenský, Jakub
Publisher: name: arXiv
Year: 2021
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11E25 (Primary), 11E12, 11R04, 11R16, 11R80 (Secondary)

description: We prove that the ring of integers in the totally real cubic subfield $K^{(49)}$ of the cyclotomic field $\mathbb{Q}(ζ_7)$ has Pythagoras number equal to $4$. This is the smallest possible value for a totally real number field of odd degree. Moreover, we determine which numbers are sums of integral squares in this field, and use this knowledge to construct a diagonal universal quadratic form in five variables.
description: 8 pages; comments are welcome
title: A grammar of Tigemaxo of Dia (Bozo, Mali)
Creators: name: Heath, Jeffrey
Publisher: name: University of Michigan
Year: 2025
Subjects: subject: Tigemaxo
subject: Bozo languages
subject: Linguistics
subject: FOS: Languages and literature
subject: Humanities
subject: FOS: Humanities

description: reference grammar
description: may also be deposited at Zenodo, for the community "Language Description Heritage". This grammar should be used in conjunction with the more or less simultaneously deposited document "Tigemaxo (Bozo) texts recorded 2022 in Dia village (Mali), with a catalog of other Tigemaxo/Tiéyaxo recordings" (Deep Blue Documents) and with "Tigemaxo lexical spreadsheets" (Deep Blue Data). Similar documents (grammars with texts, lexical spreadsheets) were previously deposited for other Bozo languages (Cliffs Jenaama, Jenaama/Sorogaama of Djenné, Kelenga).
description: reference grammar of Tigemaxo language as spoken in Dia village, Mali.
Production of recombinant soluble dimeric C-type lectin-like receptors of rat natural killer cells
Creators: name: Vaněk, Ondřej
name: Celadova, Petra
name: Skořepa, Ondřej
name: Bláha, Jan
name: Kalousková, Barbora
name: Dvorská, Anna
name: Poláchová, Edita
name: Kavan, Daniel
name: Pompach, Petr
name: Hofbauerová, Kateřina
name: Kopecký Jr., Vladimír
name: Mesci, Aruz
name: Voigt, Sebastian
name: Carlyle, James R.
Publisher: name: Robert Koch-Institut
Year: 2019
Subjects: subject: Expression systems
subject: Glycoproteins
subject: NK cells
subject: Recombinant protein therapy
subject: Transfection
subject: 610 Medizin und Gesundheit

description: Working at the border between innate and adaptive immunity, natural killer (NK) cells play a key role in the immune system by protecting healthy cells and by eliminating malignantly transformed, stressed or virally infected cells. NK cell recognition of a target cell is mediated by a receptor “zipper” consisting of various activating and inhibitory receptors, including C-type lectin-like receptors. Among this major group of receptors, two of the largest rodent receptor families are the NKR-P1 and the Clr receptor families. Although these families have been shown to encode receptor-ligand pairs involved in MHC-independent self-nonself discrimination and are a target for immune evasion by tumour cells and viruses, structural mechanisms of their mutual recognition remain less well characterized. Therefore, we developed a non-viral eukaryotic expression system based on transient transfection of suspension-adapted human embryonic kidney 293 cells to produce soluble native disulphide dimers of NK cell C-type lectin-like receptor ectodomains. The expression system was optimized using green fluorescent protein and secreted alkaline phosphatase, easily quantifiable markers of recombinant protein production. We describe an application of this approach to the recombinant protein production and characterization of native rat NKR-P1B and Clr-11 proteins suitable for further structural and functional studies.
Factorization properties for unbounded local positive maps
Creators: name: Joiţa, Maria
Publisher: name: arXiv
Year: 2021
Subjects: subject: Operator Algebras (math.OA)
subject: FOS: Mathematics

description: In this paper we present some factorization properties for unbounded local positive maps. We show that an unbounded local positive map $ϕ$ on the minimal tensor product of the locally $C^{\ast }$-algebras $\mathcal{A}$ and $C^{\ast }(\mathcal{D}_{\mathcal{E}}),$ where $\mathcal{D}_{\mathcal{E}}$ is a Fréchet quantized domain, that is dominated by $φ\otimes $id is of the forma $ψ\otimes $id, where $ψ$ is an unbounded local positive map dominated by $φ$. As an application of this result, we show that given a local positive map $φ:$ $\mathcal{A}\rightarrow $ $\mathcal{B},$ the local positive map $φ\otimes $id$_{M_{n}\left( \mathbb{C}\right) }$ is local decomposable for some $n\geq 2$ if and only if $φ$ is a local $CP$-map. Also, we show that an unbounded local $CCP$-map $ϕ$ on the minimal tensor product of the unital locally $C^{\ast }$-algebras $\mathcal{A}$ and $\mathcal{B},$ that is dominated by $φ\otimes ψ$ is of the forma $φ\otimes \widetilde{ψ}$, where $\widetilde{ψ}$ is an unbounded local $CCP$- map dominated by $ψ$, whenever $φ$ is pure.
Evidence for a high-z ISW signal from supervoids in the distribution of eBOSS quasars
Creators: name: Kovács, A.
name: Beck, R.
name: Smith, A.
name: Rácz, G.
name: Csabai, I.
name: Szapudi, I.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The late-time integrated Sachs-Wolfe (ISW) imprint of $R\gtrsim 100~h^{-1}{\rm Mpc}$ super-structures is sourced by evolving large-scale potentials due to a dominant dark energy component in the $Λ$CDM model. The aspect that makes the ISW effect distinctly interesting is the repeated observation of stronger-than-expected imprints from supervoids at $z\lesssim0.9$. Here we analyze the un-probed key redshift range $0.8
description: 13 pages, 9 figures, accepted by MNRAS after minor corrections to text and some figures
Analytical calculation of the frequency-dependent litz wire resistance considering the wire connectors
Creators: name: Barth, Daniel
name: Leibfried, Thomas
name: Cortese, Giuseppe
Publisher: name: Karlsruhe
Year: 2019
Subjects: Wireless Power Transmission
Contactless Energy Transfer
Charging Infrastructure for EV’s
Ohmic Losses

description: Eddy-current effects have an impact on the resistance of litz wire. They reduce the utilization of the wire cross section. In a certain parameter range, the dominant influencing factor is the current distribution in the wire connectors. The connector itself does not significantly contribute to the wire resistance but it results in an inhomogeneous current distribution among the strands. We quantify the resistance increase by introducing a connector skin-effect factor and give a mathematical derivation. Taking the twisting of the strands into account requires a probabilistic model of the radial strand position. Resistance measurement results validate the calculation approach. We discuss the assumptions and derive the parameter range where the model is valid.
Suppressing transthyretin production in mice, monkeys and humans using 2nd-Generation antisense oligonucleotides
Creators: name: Ackermann, Elizabeth J.
name: Shuling Guo
name: Benson, Merrill D.
name: Booten, Sheri
name: Freier, Sue
name: Hughes, Steven G.
name: Kim, Tae-Won
name: T. Jesse Kwoh
name: Matson, John
name: Norris, Dan
name: Yu, Rosie
name: Watt, Andy
name: Monia, Brett P.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Transthyretin amyloidosis (ATTR amyloidosis) is a rare disease that results from the deposition of misfolded transthyretin (TTR) protein from the plasma into tissues as amyloid fibrils, leading to polyneuropathy and cardiomyopathy. IONIS-TTRRx (ISIS 420915) is a 2nd-Generation 2′-O-(2-methoxyethyl) modified “2′-MOE” antisense oligonucleotide (ASO) that targets the TTR RNA transcript and reduces the levels of the TTR transcript through an RNaseH1 mechanism of action, leading to reductions in both mutant and wild-type TTR protein. The activity of IONIS-TTRRx to decrease TTR protein levels was studied in transgenic mice bearing the Ile84Ser human TTR mutant, in cynomolgus monkeys and in healthy human volunteers. Robust (>80%) reductions of plasma TTR protein were obtained in all three species treated with IONIS-TTRRx, which in mice and monkeys was associated with substantial reductions in hepatic TTR RNA levels. These effects were dose-dependent and lasted for weeks post-dosing. In a Phase 1 healthy volunteer study, treatment with IONIS-TTRRx for four weeks was well tolerated without any remarkable safety issues. TTR protein reductions up to 96% in plasma were observed. These nonclinical and clinical results support the ongoing Phase 3 development of IONIS-TTRRx in patients with ATTR amyloidosis.
Deterministic one-way logic gates on a cloud quantum computer
Creators: name: Yang, Zhi-Peng
name: Baishya, Alakesh
name: Ku, Huan-Yu
name: Zhang, Yu-Ran
name: Kockum, Anton Frisk
name: Chen, Yueh-Nan
name: Li, Fu-Li
name: Tsai, Jaw-Shen
name: Nori, Franco
Publisher: name: arXiv
Year: 2021
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: One-way quantum computing is a promising candidate for fault-tolerant quantum computing. Here, we propose new protocols to realize a deterministic one-way CNOT gate and one-way $X$-rotations on quantum-computing platforms. By applying a delayed-choice scheme, we overcome a limit of most currently available quantum computers, which are unable to implement further operations on measured qubits or operations conditioned on measurement results from other qubits. Moreover, we decrease the error rate of the one-way logic gates, compared to the original protocol using local operations and classical communication (LOCC). In addition, we apply our deterministic one-way CNOT gate in the Deutsch-Jozsa algorithm to show the feasibility of our proposal. We demonstrate all these one-way gates and algorithms by running experiments on the cloud quantum-computing platform IBM Quantum Experience.
Additional file 1: of DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells
Creators: name: Gu, Tianpeng
name: Lin, Xueqiu
name: Cullen, Sean
name: Luo, Min
name: Jeong, Mira
name: Estecio, Marcos
name: Shen, Jianjun
name: Hardikar, Swanand
name: Sun, Deqiang
name: Su, Jianzhong
name: Rux, Danielle
name: Guzman, Anna
name: Lee, Minjung
name: Qi, Lei
name: Chen, Jia-Jia
name: Kyba, Michael
name: Huang, Yun
name: Chen, Taiping
name: Li, Wei
name: Goodell, Margaret
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Computational Biology

description: Figure S1â S11. Figures and legends for Supplementary Figures S1â S11. (PDF 15.6Â Mb)
Additional file 1: of Estrogen-mediated gut microbiome alterations influence sexual dimorphism in metabolic syndrome in mice
Creators: name: Kaliannan, Kanakaraju
name: Robertson, Ruairi
name: Murphy, Kiera
name: Stanton, Catherine
name: Kang, Chao
name: Wang, Bin
name: Hao, Lei
name: Bhan, Atul
name: Kang, Jing
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified

description: Figure S1. Sexual dimorphism in the MS and ME and LGCI. Figure S2. Hierarchical clustering and predicted functional analysis. Figure S3. Îą-and Î˛ diversity analysis of fecal microbiota profile. Figure S4. Markers of low-grade inflammation and metabolic syndrome. Figure S5. Diversity analysis and antimicrobial peptides mRNA expression. Figure S6. The ingredients of Western diet. Table S1. Pairwise comparison of study groups with permutational multivariate analysis of variance. Table S2. Differential abundance analysis of fecal microbiota profile. Table S3. Pairwise differential abundance analysis between groups. Table S4. Primer sets used for real-time quantitative PCR. (DOC 13997 kb)
Iterative Self-consistent Parallel Magnetic Resonance Imaging Reconstruction based on Nonlocal Low-Rank Regularization
Creators: name: Pan, Ting
name: Duan, Jizhong
name: Wang, Junfeng
name: Liu, Yu
Publisher: name: arXiv
Year: 2021
Subjects: subject: Image and Video Processing (eess.IV)
subject: Signal Processing (eess.SP)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Iterative self-consistent parallel imaging reconstruction (SPIRiT) is an effective self-calibrated reconstruction model for parallel magnetic resonance imaging (PMRI). The joint L1 norm of wavelet coefficients and joint total variation (TV) regularization terms are incorporated into the SPIRiT model to improve the reconstruction performance. The simultaneous two-directional low-rankness (STDLR) in k-space data is incorporated into SPIRiT to realize improved reconstruction. Recent methods have exploited the nonlocal self-similarity (NSS) of images by imposing nonlocal low-rankness of similar patches to achieve a superior performance. To fully utilize both the NSS in Magnetic resonance (MR) images and calibration consistency in the k-space domain, we propose a nonlocal low-rank (NLR)-SPIRiT model by incorporating NLR regularization into the SPIRiT model. We apply the weighted nuclear norm (WNN) as a surrogate of the rank and employ the Nash equilibrium (NE) formulation and alternating direction method of multipliers (ADMM) to efficiently solve the NLR-SPIRiT model. The experimental results demonstrate the superior performance of NLR-SPIRiT over the state-of-the-art methods via three objective metrics and visual comparison.
Embedding EDI into research programmes: Insights from XR Stories and SIGN
Creators: name: Einarsdottir, Anna
name: Brereton, Jude
name: Swords, Jon
name: Sotiropoulou, Panagiota (Peny)
name: Reedy, Florence
name: Alormele, Naomi
Publisher: name: Zenodo
Year: 2024

description: The Screen Industries Growth Network (SIGN) and XR Stories were funded by UK Research and Innovation (UKRI) to stimulate the development of the screen industries in Yorkshire and the Humber.

From 2020–2023, SIGN developed and commissioned work on:

skills and training provision; business development support

equality, diversity and inclusion interventions

It also developed a programme of research to better understand the sector

XR Stories ran from 2018–2023 and focused on boosting R&D capacity through:

funding schemes for SMEs

academic research

internships and placements

Exclusionary practices, discrimination and exploitation are common and long-standing problems in the screen industries. Both projects aimed to embed diversity and inclusion in all activities to address them. 

As the projects ended, we commissioned AdvanceHE to evaluate what we did and how we did it and develop recommendations for similar projects.
The Implicit Desire of Conformity
Creators: name: Kolesnikov, Eugene
Publisher: name: figshare
Year: 2016
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Applied Psychology

description: The purpose of this research is to confirm the results of the Asch's experiment. We have conducted an improved Asch's experiment in the Kaplan's English School in Los Angeles and Asch's hypothesis was totally confirmed. Despite their own opinion, people don't want to stand out, so they accept the opinion of a group or an authority figure even if this opinion is going against their own beliefs.
Coronavirus Covid-19 in Papua New Guinea
Creators: name: Allen, Bryant
Publisher: name: Canberra, ACT: Dept. of Pacific Affairs, Research School of Pacific and Asian Studies, The Australian National University
Year: 2020

description: The first coronavirus Covid-19 case entered Papua New Guinea on 13 March 2020. Whether it will spread is a critical question, but it is likely. This In Brief examines two previous epidemics in PNG and then describes the population and the movements of people who will carry the virus with them, to suggest how this epidemic will develop.
Nueva versión del Campus Virtual "Studium" de la Universidad de Salamanca para afrontar el curso 2020-2021. Presentación a los representantes de los estudiantes
Creators: name: García-Peñalvo, F. J.
Publisher: name: Zenodo
Year: 2020
Subjects: Docencia universitaria; Transformación digital; Campus Virtual; Studium; COVID-19

description: Presentación de la nueva versión del Campus Virtual “Studium” de la Universidad de Salamanca a los representantes de los estudiantes, realizada en el Rectorado de la Universidad de Salamanca el 4 de septiembre de 2020.
Additional file 1 of Genome-wide identification and expression analysis of the cucumber PP2C gene family
Creators: name: Zhang, Guobin
name: Zhang, Zeyu
name: Luo, Shilei
name: Li, Xia
name: Lyu, Jian
name: Liu, Zeci
name: Wan, Zilong
name: Yu, Jihua
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Table S1. Selective pressure analysis of PP2C genes family.
Scaling Up Hardware Accelerator Verification using A-QED with Functional Decomposition
Creators: name: Chattopadhyay, Saranyu
name: Lonsing, Florian
name: Piccolboni, Luca
name: Soni, Deepraj
name: Wei, Peng
name: Zhang, Xiaofan
name: Zhou, Yuan
name: Carloni, Luca
name: Chen, Deming
name: Cong, Jason
name: Karri, Ramesh
name: Zhang, Zhiru
name: Trippel, Caroline
name: Barrett, Clark
name: Mitra, Subhasish
Publisher: name: arXiv
Year: 2021
Subjects: subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences

description: Hardware accelerators (HAs) are essential building blocks for fast and energy-efficient computing systems. Accelerator Quick Error Detection (A-QED) is a recent formal technique which uses Bounded Model Checking for pre-silicon verification of HAs. A-QED checks an HA for self-consistency, i.e., whether identical inputs within a sequence of operations always produce the same output. Under modest assumptions, A-QED is both sound and complete. However, as is well-known, large design sizes significantly limit the scalability of formal verification, including A-QED. We overcome this scalability challenge through a new decomposition technique for A-QED, called A-QED with Decomposition (A-QED$^2$). A-QED$^2$ systematically decomposes an HA into smaller, functional sub-modules, called sub-accelerators, which are then verified independently using A-QED. We prove completeness of A-QED$^2$; in particular, if the full HA under verification contains a bug, then A-QED$^2$ ensures detection of that bug during A-QED verification of the corresponding sub-accelerators. Results on over 100 (buggy) versions of a wide variety of HAs with millions of logic gates demonstrate the effectiveness and practicality of A-QED$^2$.
description: preprint of a paper to appear at FMCAD 2021, including appendix
Willingness-to-pay for value-added freshwater prawns
Creators: name: Freeman, Matthew Alan
name: Coatney, Kalyn
name: Schilling, Mark
name: Allen, Peter
name: Ciaramella, Michael
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: 60506 Virology

description: This article utilizes sensory analysis and auction experimental design to examine consumer willingness-to-pay for value-added freshwater prawns relative to the standard freshwater prawn. Although the combination of these two techniques has been previously applied to other food products, this is the first time that prawns have been the focus of such a study. Consumer willingness-to-pay was found to be significantly enhanced by two alternative salt processes, salt acclimation and marination. Results also show that salt acclimation had a stronger effect than marination on consumer bids, with flavor being the most significant sensory attribute.
The Realistic Scattering of Puffy Dark Matter
Creators: name: Wang, Wenyu
name: Xu, Wu-Long
name: Zhu, Bin
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: If dark matter has a finite size, the intrinsic interaction responsible for the structure formation is inevitable from the perspective of dark matter self-scattering. To describe the circumstance in which the binding force realizes the finite size dark protons, we first use the Eikonal approximation to simplify the convoluted scattering between dark protons into the case at the $t=0$ limit. The Chou-Yang model is then introduced to reduce the number of input parameters to one based on the simplicity and analyticity principle. A new definition of velocity dependence and the corresponding implications on the small cosmological structures from Chou-Yang dark protons are shown clearly. Even though the parameter space is not fully covered, the numerical findings show that the amplitude coefficient can alter the self-scattering cross-section, allowing us to recover the excluded parameter space without using binding force. Finally, we demonstrate that the correct relic density from thermal freeze-out production prefers super heavy dark protons.
description: 5 pages, 3 figure
Traversable wormhole solutions with non-exotic fluid in framework of $f(Q)$ gravity
Creators: name: Sharma, Umesh Kumar
name: Shweta
name: Mishra, Ambuj Kumar
Publisher: name: arXiv
Year: 2021
Subjects: subject: General Physics (physics.gen-ph)
subject: FOS: Physical sciences

description: The presence of exotic matter for the existence of the wormhole geometry has been an unavoidable problem in GR. In recent studies researchers have tried to deal with this issue using modified gravity theories where the WH geometry is explained by the extra curvature terms and NEC's are not violated signifying the standard matter in the WH geometry. In the present article we are trying to find the solutions of traversable wormholes with normal matter in the throat within the framework of symmetric teleparallel gravity $f(Q)$ where $Q$ is the non metricity scalar which defines the gravitational interaction. We will examine the wormhole geometries for three forms of function $f(Q)$. First is the linear form $f(Q)=αQ$, second a non -linear form $f(Q)=αQ^2 + β$ and third one a more general quadratic form $f(Q)=αQ^2 + βQ + γ$ with $α$, $β$ and $γ$ being the constants. For all the three cases the shape function is taken as $b(r) = {\frac{r_{0}\ln(r+1)}{\ln({r_0}+1)}}$ where $r_0$ is the throat radius. A special variable redshift function is considered for the discussion. All the energy conditions are then examined for the existence and the stability of the wormhole geometry.
description: 20 pages, 12 figures
The Role of Quality Health Services and Discussion about Birth Spacing in Postpartum Contraceptive Use in Sindh, Pakistan: A Multilevel Analysis
Creators: name: Anayat Ali
Publisher: name: figshare
Year: 2016
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Rapid population growth, stagnant contraceptive prevalence, and high unmet need for family planning present significant challenges for meeting Pakistan’s national and international development goals. Although health behaviors are shaped by multiple social and environmental factors, research on contraceptive uptake in Pakistan has focused on individual and household determinants, and little attention has been given to community characteristics that may affect access to services and reproductive behavior.
Additional file 2 of Genome-wide identification and expression analysis of the cucumber PP2C gene family
Creators: name: Zhang, Guobin
name: Zhang, Zeyu
name: Luo, Shilei
name: Li, Xia
name: Lyu, Jian
name: Liu, Zeci
name: Wan, Zilong
name: Yu, Jihua
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Table S2. Conserved motifs in the amino acid sequences of CsPP2C proteins.
title: Synthese und Charakterisierung von Submikro- und Nanodrahtarrays aus Platin und Nickel-Eisen zur Anwendung in mikroelektromechanischen Systemen
Creators: name: Hottes, Martin
Publisher: name: UNSPECIFIED
Year: 2020

description: Aufbauend auf der Forschung der Fachgebiete Materialanalytik [3-5], Materialforschung [6-8] und Mikrotechnik und elektromechanische Systeme [9-11] werden Nanodrahtarrays „NDAs“ und Submikrodrahtarrays „SDAs“ synthetisiert und deren Eigenschaften hinsichtlich deren technischer Anwendbarkeit untersucht. Über die Ionenspur-Templatmethode können, mit der Wahl der Lochmaske, der Polymerfoliendicke, der Fluenz und der Ätzzeit, Template mit Nanokanälen mit genau definierten geometrischen Eigenschaften hergestellt werden. Die Anpassung der elektrochemischen Abscheidebedingungen der dann eingebetteten NDAs und SDAs führt zu einer hohen Ausbeute an simultan gleichmäßig gewachsenen Arrays. Das Rasterelektronenmikroskop bestätigt eine Erhaltung ihrer Gestalt und Größe nach der Optimierung des Freilegungsprozesses der im Templat gewachsenen Arrays. Für eine systematische Studie des mechanischen Verhaltens und einen Vergleich zwischen NDAs einerseits und SDAs andererseits wurde jeweils eine Serie von Arrays aus den Materialien Platin und Nickel-Eisen hergestellt. Neben den Materialien unterscheiden sich diese Arrays hauptsächlich in der Drahtanzahl, dem Drahtdurchmesser auf Nano- und Submikrometerebene sowie der Drahtlänge. Mit der Konzipierung, dem Aufbau und der Inbetriebnahme eines neu entwickelten Nanokraftmessplatzes ist es gelungen, die freistehenden NDAs und SDAs in Hinblick auf ihr mechanisches Verhalten zu untersuchen. Dies erfolgte über die Aufzeichnung von Kraft-Weg-Kurven, die durch eine laterale Verschiebung der Arrays und der Messung der daraus resultierenden Kraft entstehen. Der Einfluss des Drahtdurchmessers, der Drahtanzahl und der Drahtlänge auf die Federkonstante der Arrays wird durch ein analytisches Modell abgebildet und mit den Messergebnissen bestätigt. Die Ergebnisse zeigen, dass die Arrays über ihre geometrischen Eigenschaften gezielt mechanisch adaptierbar sind: Erwartungsgemäß lässt sich die Federkonstante reduzieren durch kleinere Drahtdurchmesser, eine kleinere Drahtanzahl und größere Drahtlängen. Sowohl die NDAs als auch die SDAs sind sehr stabil und können erfolgreich mechanisch charakterisiert werden. Die Ergebnisse legen den Grundstein für die Anwendung in neuartigen Beschleunigungssensoren und das gewonnene Wissen kann dazu eingesetzt werden, um Arrays mit einer bestimmten Federkonstante durch Anpassung der geometrischen Eigenschaften herzustellen. Die für den geplanten Einsatz als Feder-Masse-Element im Beschleunigungssensor am besten geeigneten Arrays besitzen eine kreisförmige Grundfläche mit einem Durchmesser von 50 µm und einer Drahtlänge von 30 µm, da sie eine bemerkenswerte Flexibilität gegenüber lateralen Biegebelastungen, ausgeprägte Stabilitäten über mehrere Belastungszyklen und reproduzierbare Federkonstanten besitzen, die über den Drahtdurchmesser und die Drahtanzahl eingestellt werden können.
A new form of the Machin-like formula for pi by iteration with increasing integers
Creators: name: Abrarov, Sanjar M.
name: Siddiqui, Rehan
name: Jagpal, Rajinder K.
name: Quine, Brendan M.
Publisher: name: arXiv
Year: 2021
Subjects: subject: General Mathematics (math.GM)
subject: FOS: Mathematics
subject: 11Y60

description: We present a new form of the Machin-like formula for $π$ that can be generated by using iteration. This form of the Machin-like formula may be promising for computation of the constant $π$ due to rapidly increasing integers at each step of the iteration. The computational test we performed shows that, with an integer $k \ge 17$, the Lehmer measure remains small and practically does not increase after $18$ steps of iteration.
description: 20 pages. Link to the file 'suppliment.txt' with Mathematica programs is provided
Additional file 2: of DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells
Creators: name: Gu, Tianpeng
name: Lin, Xueqiu
name: Cullen, Sean
name: Luo, Min
name: Jeong, Mira
name: Estecio, Marcos
name: Shen, Jianjun
name: Hardikar, Swanand
name: Sun, Deqiang
name: Su, Jianzhong
name: Rux, Danielle
name: Guzman, Anna
name: Lee, Minjung
name: Qi, Lei
name: Chen, Jia-Jia
name: Kyba, Michael
name: Huang, Yun
name: Chen, Taiping
name: Li, Wei
name: Goodell, Margaret
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: Developmental Biology
subject: Marine Biology
subject: Cancer

description: Table S1. List of oligonucleotides: guide sgRNAs and primers. (PDF 52 Kb)