Additional file 1 of An empirical evaluation of the impact scenario of pooling bodies of evidence from randomized controlled trials and cohort studies in medical research
Creators: name: Bröckelmann, Nils
name: Stadelmaier, Julia
name: Harms, Louisa
name: Kubiak, Charlotte
name: Beyerbach, Jessica
name: Wolkewitz, Martin
name: Meerpohl, Jörg J.
name: Schwingshackl, Lukas
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Additional file 1: Appendix S1. Search strategy. Tables S1-S5. Table S1. Explanation and definition for PI/ECO similarity degree. Table S2. PI/ECO similarity degree. Table S3. Differences between published (reported) effect estimates and re-calculated effect estimates. Table S4. Reason for exclusion from the pooling scenario. Table S5. Pooling results. Figures S1-S118. Fig S1. Forest plot: Low sodium (Intervention/Exposure); All-cause mortality (Outcome). Fig. S2. Forest plot: Low sodium; Cardiovascular disease. Fig. S3. Forest plot: Intra-aortic balloon pump; All-cause mortality. Fig. S4. Forest plot: Self-administered therapy; Treatment success. Fig S5. Forest plot: Self-administered therapy; Treatment completion. Fig. S6. Forest plot: Self-administered therapy; All-cause mortality. Fig S7. Forest plot: Antiretroviral therapy; HIV infection. FigS8-Forest plot: Nonnutritive sweeteners; Body Mass Index random sequence. Fig. S9. Forest plot: Surgical abortion by mid-level providers; Failure or incomplete abortion. Fig. S10. Forest plot: Surgical abortion by mid-level providers; Complications. Fig. S11. Forest plot: Surgical abortion by mid-level providers; Abortion failure and complications. Fig. S12. Forest plot: Clopidogrel pretreatment for percutaneous coronary intervention; All-cause mortality. Fig. S13. Forest plot: Clopidogrel pretreatment for percutaneous coronary intervention; Major bleeding. Fig. S14. Forest plot: Clopidogrel pretreatment for percutaneous coronary intervention; Coronary heart disease. Fig. S15. Forest plot: P2Y12 inhibitor pretreatment in non-ST elevation acute coronary syndrome; All-cause mortality. Fig. S16. Forest plot: P2Y12 inhibitor pretreatment in non-ST elevation acute coronary syndrome; Major bleeding. Fig. S17. Forest plot: P2Y12 inhibitor pretreatment in non-ST elevation acute coronary syndrome; Main composite ischemic endpoint. Fig. S18. Forest plot: Mediterranean diet; Breast cancer. Fig. S19. Forest plot: High calcium; All fractures. Fig. S20. Forest plot: High calcium; Verterbral fractures. Fig. S21. Forest plot: High calcium; Hip fracture. Fig. S22. Forest plot: Sigmoidoscopy; Colorectal cancer mortality. Fig. S23. Forest plot: Sigmoidoscopy; Colorectal cancer incidence. Fig. S24. Forest plot: High omega-3; Cerebrovascular disease. Fig. S25. Forest plot: High α-linolenic acid; Coronary heart disease. Fig. S26. Forest plot: High omega-3; Coronary heart disease. Fig. S27. Forest plot: Omega-6; Coronary heart disease. Fig. S28. Forest plot: High calcium; Cardiovascular mortality. Fig. S29. Forest plot: High dairy; Systolic blood pressure. Fig. S30. Forest plot: Radiation therapy; Erectile dysfunction. Fig. S31. Forest plot: Radical prostatectomy; Urinary incontinence. Fig. S32. Forest plot: Radical Prostatectomy; Erectile dysfunction. Fig. S33. Forest plot: Disease-modifying drugs; Conversion to clinically definite multiple sclerosis. Fig. S34. Forest plot: Extracranial-intracranial arterial bypass; All-cause mortality. Fig. S35. Forest plot: Extracranial-intracranial arterial bypass; Stroke. Fig. S36. Forest plot: Extracranial-intracranial arterial bypass; Stroke mortality or dependency. Fig. S37. Forest plot: Transcatheter aortic valve implantation; Early all-cause mortality. Fig. S38. Forest plot: Transcatheter aortic valve implantation; Mid-term all-cause mortality. Fig. S39. Forest plot: Transcatheter aortic valve implantation; Long-term all-cause mortality. Fig. S40. Forest plot: Treating gestational diabetes mellitus; High birth weight. Fig. S41. Forest plot: Treating gestational diabetes mellitus; Large-for-gestational age neonate. Fig. S42. Forest plot: Treating gestational diabetes mellitus; Shoulder dystocia. Fig. S43. Forest plot: Treating asymptomatic bacteriuria; Pyelonephritis. Fig. S44. Forest plot: Bacillus Calmette-Guérin vaccination; All-cause mortality. Fig. S45. Forest plot: Measles containing vaccines; All-cause mortality. Fig. S46. Forest plot: Total hip arthroplasty; Reoperation. Fig. S47. Forest plot: Total hip arthroplasty; Dislocation. Fig. S48. Forest plot: Total hip arthroplasty; Deep infection. Fig. S49. Forest plot: Chest-compression-only cardiopulmonary resuscitation; Survival. Fig. S50. Forest plot: Non-calcium-based phosphat binders; All-cause mortality. Fig. S51. Forest plot: Parenteral influenza vaccine; Influenza-like illness. Fig. S52. Forest plot: Parenteral influenza vaccine Influenza. FigS53-Forest plot: Inactivated influenza vaccines; Influenza. Fig. S54. Forest plot: Inactivated influenza vaccines; Influenza-like illness. Fig. S55. Forest plot: High total flavonoids; Colorectal neoplasms. Fig. S56. Forest plot: Transfusion; All-cause mortality. Fig. S57. Forest plot: Caesarean section; Urinary incontinence. Fig. S58. Forest plot: Caesarean section; Fecal incontinence. Fig. S59. Forest plot: Antiretroviral therapy by nurses; All-cause mortality. Fig. S60. Forest plot: Antiretroviral therapy by nurses; Attrition. Fig. S61. Forest plot: Nurses for maintenance of antiretroviral therapy; All-cause mortality. Fig. S62. Forest plot: Exenatide; Acute pancreatitis. Fig. S63. Forest plot: DDP-4 inhibitors; Heart failure. Fig. S64. Forest plot: DDP-4 inhibitors; Hospital admission for heart failure. Fig. S65. Forest plot: Tamoxifen; Heart failure. Fig. S66. Forest plot: SGLT-2 inhibitors; Acute kidney injury. Fig. S67. Forest plot: Erythropoiesis stimulating agents; Venous thromboembolism. Fig. S68. Forest plot: Erythropoiesis stimulating agents; All-cause mortality. Fig. S69. Forest plot: Pneumococcal polysaccharide vaccines; Invasive pneumococcal disease. Fig. S70. Forest plot: Neoral (Cyclosporin); Acute rejection of kidney transplant. Fig. S71. Forest plot: Early intervention for NSTE-ACS; All-cause mortality. Fig. S72. Forest plot: Early intervention for NSTE-ACS; Myocardial infarction. Fig. S73. Forest plot: Early intervention for NSTE-ACS; Major bleeding. Fig. S74. Forest plot: Caesarean section; Anal incontinence; feces. Fig. S75. Forest plot: Caesarean section; Anal incontinence; flatus. Fig. S76. Forest plot: Ceramic-on-ceramic bearings for total hip arthroplasty; Harris Hip Score. Fig. S77. Forest plot: High-flexion total knee arthroplasty; Flexion in degrees. Fig. S78. Forest plot: Gender-specific total knee arthroplasty; Flexion-extension range. Fig. S79. Forest plot: Second generation antipsychotics; Sedation. Fig. S80. Forest plot: Second generation antipsychotics; Neurologic outcomes. Fig. S81. Forest plot: Surgery for achilles tendon rupture; Re-rupture. Fig. S82. Forest plot: Surgery for achilles tendon rupture; Complications. Fig. S83. Forest plot: High vitamin D; Hypertension. Fig. S84. Forest plot: Carotid endarterectomy; Ipsilateral stroke. FigS85-Forest plot: Carotid endarterectomy; Stroke. Fig. S86. Forest plot: Carotid artery stenting; Periprocedural stroke. Fig. S87. Forest plot: Nasal deconolization; Surgical site infection. Fig. S88. Forest plot: Glycopeptide prophylaxis; Surgical site infection. Fig. S89. Forest plot: Enoxaparin; All-cause mortality. Fig. S90. Forest plot: Enoxaparin; Major bleeding. Fig. S91. Forest plot: Enoxaparin; All-cause mortality or myocardial infarction. Fig. S92. Forest plot: Antiretroviral therapy; Tuberculosis infection. Fig. S93. Forest plot: High sugar intake; Weight gain. Fig. S94. Forest plot: High sugar intake; Body Mass Index. Fig. S95. Forest plot: Influenza vaccines; Influenza-like illness. Fig. S96. Forest plot: Mefloquine; Discontinuation due to adverse effects. Fig. S97. Forest plot: Mefloquine; Serious adverse events or effects. Fig. S98. Forest plot: Mefloquine; Nausea. Fig. S99. Forest plot: Live-attenuated zoster vaccines; Suspected Herpes Zoster. Fig. S100. Forest plot: High selenium; Cancer. Fig. S101. Forest plot: High selenium; Cancer mortality. FigS102-Forest plot: High selenium; Colorectal cancer. FigS103-Forest plot: Training for traditional birth attendants/ assistance by traditional birth attendants; Perinatal mortality. Fig. S104. Forest plot: Training for traditional birth attendants/ assistance by traditional birth attendants; Neonatal mortality. Fig. S105. Forest plot: Unicompartimental knee arthroplasty; Venous thromboembolism. Fig. S106. Forest plot: Unicompartimental knee arthroplasty; Flexion-extension range. Fig. S107. Forest plot: Unicompartimental knee arthroplasty; Operation duration. Fig. S108. Forest plot: Recombinant factor VII; All-cause mortality. Fig. S109. Forest plot: Recombinant factor VII; Thromboembolism. Fig. S110. Forest plot: Everolimus-eluting bioresorbable vascular scaffold; Stent thrombosis. Fig. S111. Forest plot: Everolimus-eluting bioresorbable vascular scaffold; All-cause mortality. Fig. S112. Forest plot: Everolimus-eluting bioresorbable vascular scaffold; Coronary heart disease mortality. Fig. S113. Forest plot: Percutaneous coronary intervention; All-cause mortality. Fig. S114. Forest plot: Percutaneous coronary intervention; Cardiovascular mortality. Fig. S115. Forest plot: Percutaneous coronary intervention; Myocardial infarction. Fig. S116. Forest plot: Digoxin; All-cause mortality. Fig. S117. Forest plot: Digoxin; Cardiovascular mortality. Fig. S118. Forest plot: Digoxin; Hospital admission.