cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A Phase I Clinical Trial of Systemically Delivered NEMO Binding Domain Peptide in Dogs with Spontaneous Activated B-Cell like Diffuse Large B-Cell Lymphoma
Creators: name: Mason, Nicola J.
name: Patel, Reema
name: Propert, Kathleen J.
name: Flood, Patrick
name: Krick, Erika
name: May, Michael J.
name: Habineza Ndikuyeze, Georges
name: Gaurnier-Hausser, Anita
name: Baldwin, Albert S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Activated B-Cell (ABC) Diffuse Large B-Cell Lymphoma (DLBCL) is a common, aggressive and poorly chemoresponsive subtype of DLBCL, characterized by constitutive canonical NF-κB signaling. Inhibition of NF-κB signaling leads to apoptosis of ABC-DLBCL cell lines, suggesting targeted disruption of this pathway may have therapeutic relevance. The selective IKK inhibitor, NEMO Binding Domain (NBD) peptide effectively blocks constitutive NF-κB activity and induces apoptosis in ABC-DLBCL cells in vitro. Here we used a comparative approach to determine the safety and efficacy of systemic NBD peptide to inhibit constitutive NF-κB signaling in privately owned dogs with spontaneous newly diagnosed or relapsed ABC-like DLBCL. Malignant lymph nodes biopsies were taken before and twenty-four hours after peptide administration to determine biological effects. Intravenous administration of <2 mg/kg NBD peptide was safe and inhibited constitutive canonical NF-κB activity in 6/10 dogs. Reductions in mitotic index and Cyclin D expression also occurred in a subset of dogs 24 hours post peptide and in 3 dogs marked, therapeutically beneficial histopathological changes were identified. Mild, grade 1 toxicities were noted in 3 dogs at the time of peptide administration and one dog developed transient subclinical hepatopathy. Long term toxicities were not identified. Pharmacokinetic data suggested rapid uptake of peptide into tissues. No significant hematological or biochemical toxicities were identified. Overall the results from this phase I study indicate that systemic administration of NBD peptide is safe and effectively blocks constitutive NF-κB signaling and reduces malignant B cell proliferation in a subset of dogs with ABC-like DLBCL. These results have potential translational relevance for human ABC-DLBCL.
Scattering amplitudes in Lifshitz spacetime
Creators: name: Andrade, Tomas
name: Lei, Yang
name: Ross, Simon F.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider the calculation of scattering amplitudes in field theories dual to Lifshitz spacetimes. These amplitudes provide an interesting probe of the IR structure of the field theory; our aim is to use them to explore the observable consequences of the singularity in the spacetime. We assume the amplitudes can be related by T-duality to a Wilson loop, as in the AdS case, and determine the bulk minimal surfaces for the simplest cusp Wilson loop. We use this to determine the leading IR singularity in the amplitude. We find there is a stronger IR singularity for z >1 than for z=1, with a coefficient which vanishes as z goes to 1.
description: 14 pages, 8 figures
A Putatively Functional Polymorphism in the HTR2C Gene is Associated with Depressive Symptoms in White Females Reporting Significant Life Stress
Creators: name: Babyak, Michael A.
name: Siegler, Ilene C.
name: Brummett, Beverly H.
name: Williams, Redford B.
name: Harris, Kathleen Mullan
name: Costa, Paul T.
name: Singh, Abanish
name: Jiang, Rong
name: Georgiades, Anastasia
name: Kraus, William E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Psychosocial stress is well known to be positively associated with subsequent depressive symptoms. Cortisol response to stress may be one of a number of biological mechanisms that links psychological stress to depressive symptoms, although the precise causal pathway remains unclear. Activity of the x-linked serotonin 5-HTR2C receptor has also been shown to be associated with depression and with clinical response to antidepressant medications. We recently demonstrated that variation in a single nucleotide polymorphism on the HTR2C gene, rs6318 (Ser23Cys), is associated with different cortisol release and short-term changes in affect in response to a series of stress tasks in the laboratory. Based on this observation, we decided to examine whether rs6318 might moderate the association between psychosocial stress and subsequent depressive symptoms. In the present study we use cross-sectional data from a large population-based sample of young adult White men (N = 2,366) and White women (N = 2,712) in the United States to test this moderation hypothesis. Specifically, we hypothesized that the association between self-reported stressful life events and depressive symptoms would be stronger among homozygous Ser23 C females and hemizygous Ser23 C males than among Cys23 G carriers. In separate within-sex analyses a genotype-by-life stress interaction was observed for women (p = .022) but not for men (p = .471). Homozygous Ser23 C women who reported high levels of life stress had depressive symptom scores that were about 0.3 standard deviations higher than female Cys23 G carriers with similarly high stress levels. In contrast, no appreciable difference in depressive symptoms was observed between genotypes at lower levels of stress. Our findings support prior work that suggests a functional SNP on the HTR2C gene may confer an increased risk for depressive symptoms in White women with a history of significant life stress.
Towards energy optimized cities
Creators: name: Hainoun, Ali
name: Etminan, Ghazal
Publisher: name: TECHNE - Journal of Technology for Architecture and Environment
Year: 2018

description: This work deals with the application of a bottom-up and scenario-based approach to analyse the future urban energy development. For this purpose, consistent scenarios of long term socio-economic, technological and demographic developments of the considered urban area are prepared. The key development parameters focus on technology and infrastructure transformation related to EE improvement and electrification in all consumption sectors, including the shifts in mobility modes and lifestyle changes driven by financial incentives and environmental awareness. The concept systematically relates the specific energy needs for producing various services and commodities to the social, economic and technological factors that affect the demand for a particular fuel.
description: TECHNE - Journal of Technology for Architecture and Environment, TECHNE: Special Series Vol. 1
Caliothrips phaseoli (thysanoptera: thripidae) como depredador facultativo del ácaro rojo tetranychus merganser boudreaux (Acari:Tetranychidae)
Creators: name: Villagrana Mancilla, Carlos.
Publisher: name: Universidad Autónoma de Baja California, Ensenada.
Year: 2023
Subjects: subject: Ácaros Agronomía||Tesis y disertaciones académicas.
subject: SB940 V55 2022

description: La aparición de plagas en los cultivos bajo condiciones de invernadero como los trips es sorpresiva. Estos insectos se han encontrado presentes en una amplia gama de cultivos, tornándose una plaga de importancia económica en varias regiones del mundo por sus hábitos alimenticios y por las patologías que transmite a los cultivos.
Linking future energy systems with heritage requalification in Smart Cities. On-going research and experimentation in the city of Trento (IT)
Creators: name: Andreucci, Maria Beatrice
Publisher: name: TECHNE - Journal of Technology for Architecture and Environment
Year: 2018

description: Future Energy Systems in midsized Italian Smart Cities are highly dependent upon the pursuit of a smarter grid based on active end-user engagement, the use of distributed energy resources and real-time demand response. In Trento, due to its climatic conditions, the issue of smart energy systems is particularly relevant and its future smart electric grid is expected to produce energy efficiency improvements to the city’s historic municipal buildings, as well as to private residences and businesses. With the contribution of Trento’s Smart City Municipal Office, latest evidence of current approach to urban smart energy systems is presented, highlighting strategies and innovative solutions, benefitting the whole
description: TECHNE - Journal of Technology for Architecture and Environment, TECHNE: Special Series Vol. 1
Characterization of Interface Traps in SiO$_2$/SiC Structures Close to the Conduction Band by Deep-Level Transient Spectroscopy
Creators: name: Hatakeyama, Tetsuo
name: Sometani, Mitsuru
name: Yonezawa, Yoshiyuki
name: Fukuda, Kenji
name: Okumura, Hajime
name: Kimoto, Tsunenobu
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The effects of the oxidation atmosphere and crystal faces on the interface-trap density was examined by using constant-capacitance deep-level transient spectroscopy to clarify the origin of them. By comparing the DLTS spectra of the low-mobility interfaces oxidized in a N$_2$O atmosphere with those of the high-mobility interfaces on C-face oxidized in a wet atmosphere, it was found that a high density of traps are commonly observed around the energy of 0.16 eV from the edge of the conduction band ($C1$ traps) in low-mobility interfaces irrespective of crystal faces. It was also found that the generation and elimination of traps specific to crystal faces: (1) the $C1$ traps can be eliminated by wet oxidation only on the C-face, and (2) the $O2$ traps (0.37 eV) can be observed in the SiC/SiO$_2$ interface only on the Si-face. The generation of $O2$ traps on the Si-face and the elimination of $C1$ traps on the C-face by wet oxidation may be caused by the oxidation reaction specific to the crystal faces.
description: 12 pages, 4 figures
Estimation of BDS-3 Differential Code Bias with Satellite Phase Center Offset Correction Applied
Creators: name: Wang, Ningbo
name: Li, Yang
name: Li, Zishen
name: Wang, Liang
name: Li, Zongyi
Publisher: name: Zenodo
Year: 2022

description: The precise different code bias (DCB) correction information is basically required in the high-precision applications of multi-frequency Global Navigation Satellite Systems (GNSS). It is noted that the phase center offset (PCO) errors have not yet been properly handled in the generation of GNSS DCBs. In this paper, we first checked the variation characteristics of satellite PCOs of BeiDou global navigation satellite system (BDS-3), and analyzed the PCO effects on the generated BDS-3 DCBs. The empirical PCO correction model for DCBs (i.e., PCO-corrected-DCB) is then proposed, and the DCB estimation method with PCO correction applied (i.e., PCO-estimated-DCB) is also presented. Using BDS-3 observation data from the International GNSS Service (IGS) stations, the BDS-3 C2I/C1P/C1X-C6I DCBs with/without PCO corrections are estimated. The BDS-3 C2I/C1P single-frequency standard point positioning (SF-SPP) utilizing precise satellite orbits and clocks is performed to check the quality of the generated DCBs. Results show that the differences between DCBs estimated with and without PCO corrections reach 0.60 ns. The DCB discrepancy between different satellite types of BDS-3 is up to 1.16 ns, indicating the PCO errors in the generated DCBs can not be ignored in the associated positioning applications. Compared to the BDS-3 SF-SPP result applying DCBs without PCO corrections, the positioning accuracy improves by 1.0% and 9.6% in horizontal and vertical components for PCO-corrected-DCBs, which corresponds to 5.6% and 15.7% for PCO-estimated-DCBs. Since the temporal variation of PCO errors are properly handled in the estimated DCBs with PCO correction applied, the notable improvement in PCO-estimated-DCB based positioning can be foreseen, compared to the PCO-corrected-DCB based solution.
ผลของการใช้ไลน์แอปพลิเคชันสื่อสารข้อมูลทันตสุขภาพในผู้ปกครองเด็กปฐมวัย อำเภอลอง จังหวัดแพร่
Creators: name: ปฐมพงษ์ คำแดง
Publisher: name: สำนักทันตสาธารณสุข กรมอนามัย
Year: 2023
Subjects: การสื่อสารข้อมูลทันตสุขภาพ
ผู้ปกครอง
เด็กปฐมวัย
ไลน์แอปพลิเคชัน
ทฤษฎีอุปนิสัย 21 วัน

description: วิทยาสารทันตสาธารณสุข, 28, , 118-131
title: British Journal for Military History, Vol 8 No 2 (2022): Special Issue - Prof. Sir Michael Howard
title: Special Issue - Prof. Sir Michael Howard
titleType: AlternativeTitle
Creators: name: British Journal For Military History
Publisher: name: British Journal for Military History
Year: 2022

description: Editorial...1 War, Technology and Narrative Hierarchies...119-124 Michael Howard and the Historian’s Craft: An Introduction to the Michael Howard Special Issue...2-26 A liberal tries to be conscientious about teaching war in the shadow of Sir Michael Howard...27-35 A European History of Michael Howard’s War in European History...36-54 The Unrepentant Historian: Sir Michael Howard and the birth of War Studies...55-76 Revisiting the Translators and Translations of Clausewitz’s On War...77-102 Deterrence & Reassurance: Sir Michael Howard and the Nuclear Strategy Debate in the 1980s...103-118
Quels niveaux de connaissances des traitements antirétroviraux pour la prévention du VIH chez les immigrés d'Afrique subsaharienne vivant en situation de précarité en Île-de-France ? Résultats du projet Makasi
Creators: name: Coulibaly, Karna
Publisher: name: Zenodo
Year: 2022

description: En France, les immigrés originaires d’Afrique subsaharienne sont particulièrement touchés par l’infection VIH. Les outils de la prévention combinée, notamment les traitements antirétroviraux comme le traitement comme prévention (TasP), la prophylaxie préexposition (PrEP) et le traitement post-exposition (TPE) constituent une approche novatrice pour éviter les nouvelles infections dans cette population. A partir des données collectées auprès de 601 personnes dans le projet Makasi entre février 2019 et décembre 2020, nous décrivons la connaissance de ces traitements chez les immigrés originaires d’Afrique subsaharienne en situation de précarité et ce qui favorise ces connaissances. L’étude Makasi a inclus une population qui cumule d’importantes situations de précarité : 69% sans activité professionnelle, 74% sans titre de séjour, 46% sans couverture maladie et 72% sans logement stable. Dans cette population, les niveaux de connaissance des outils de la prévention combinée sont hétérogènes. Les résultats montrent que les services de santé sexuelles sont connus et le dépistages est très pratiqué. A l’inverse, les traitements antirétroviraux sont faiblement connus. Ces résultats invitent à accentuer la communication autour de la prévention du VIH dans cette population en situation de précarité.
Revisiting the Translators and Translations of Clausewitz’s On War
Creators: name: Melvin, Mungo
Publisher: name: British Journal for Military History
Year: 2022

description: The English translations of Carl von Clausewitz’s On War from that of Colonel John James Graham (1873) through Matthijs Jolles (1943) to the most commonly read today by Michael Howard and Peter Paret (1976) differ in readability and reliability. Although the latter is widely considered as the most accessible and has become accepted as the modern ‘standard’, it contains a number of unfortunate mistranslations. If On War is to reflect more faithfully what Clausewitz meant while remaining relevant for today it demands a new translation of a text that holds many challenges.
description: British Journal for Military History, Vol 8 No 2 (2022): Special Issue - Prof. Sir Michael Howard
A Rare Duplication on Chromosome 16p11.2 Is Identified in Patients with Psychosis in Alzheimer's Disease
Creators: name: Zheng, Xiaojing
name: Sweet, Robert A.
name: Barmada, M. Michael
name: Lopez, Oscar L.
name: Kamboh, M. Ilyas
name: Feingold, Eleanor
name: Demirci, F. Yesim
name: Richardson, Gale A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Epidemiological and genetic studies suggest that schizophrenia and autism may share genetic links. Besides common single nucleotide polymorphisms, recent data suggest that some rare copy number variants (CNVs) are risk factors for both disorders. Because we have previously found that schizophrenia and psychosis in Alzheimer's disease (AD+P) share some genetic risk, we investigated whether CNVs reported in schizophrenia and autism are also linked to AD+P. We searched for CNVs associated with AD+P in 7 recurrent CNV regions that have been previously identified across autism and schizophrenia, using the Illumina HumanOmni1-Quad BeadChip. A chromosome 16p11.2 duplication CNV (chr16: 29,554,843-30,105,652) was identified in 2 of 440 AD+P subjects, but not in 136 AD subjects without psychosis, or in 593 AD subjects with intermediate psychosis status, or in 855 non-AD individuals. The frequency of this duplication CNV in AD+P (0.46%) was similar to that reported previously in schizophrenia (0.46%). This duplication CNV was further validated using the NanoString nCounter CNV Custom CodeSets. The 16p11.2 duplication has been associated with developmental delay, intellectual disability, behavioral problems, autism, schizophrenia (SCZ), and bipolar disorder. These two AD+P patients had no personal of, nor any identified family history of, SCZ, bipolar disorder and autism. To the best of our knowledge, our case report is the first suggestion that 16p11.2 duplication is also linked to AD+P. Although rare, this CNV may have an important role in the development of psychosis.
A European History of Michael Howard’s War in European History
Creators: name: Wilcox, Vanda
Publisher: name: British Journal for Military History
Year: 2022

description: Michael Howard’s War in European History, published in 1976, was one of his most influential works. This article traces its reception in France, Italy and West Germany, contextualising the book within the post-Second World War development of military history in those countries. The ‘war and society’ approach for which Howard is celebrated developed along distinctive lines in each, so international scholars focused on different aspects of the book. War in European History was also used by Umberto Eco to explore the relationship between force and power. His insights offer fresh ways to examine more recent developments in the field of military history.
description: British Journal for Military History, Vol 8 No 2 (2022): Special Issue - Prof. Sir Michael Howard
Estudio de la influencia de los grupos hidroxilo en el depósito por capa atómica para el crecimiento de ZnO sobre grafeno
Creators: name: Borbón Núñez, Hugo Alejandro.
Publisher: name: Universidad Autónoma de Baja California, Ensenada.
Year: 2023
Subjects: Ingeniería||Tesis y disertaciones académicas.

description: La sinergia entre el grafeno y el ZnO para la formación de nanomateriales híbridos con propiedades novedosas y de interés para la industria tecnológica requiere del desarrollo de procesos y técnicas que permitan su crecimiento controlado.
Regional Energy Transition (RET): how to improve the connection of praxis and theory?
Creators: name: Engelenburg, Barend
name: Maas, Nienke
Publisher: name: TECHNE - Journal of Technology for Architecture and Environment
Year: 2018

description: A regional energy transition (RET) implies a drastic transformation of the energy system and, hence, a lot of challenges. A RET calls for an integrative local approach. In this essay we describe and compare the current practice and the state of knowledge on this topic. We find that theory has not yet developed sufficiently to address the practical challenges. Part of the problem is that what has been developed has too little connection with local practice. We conclude that the development of theoretical knowledge must be better attuned to the needs of the practitioners.
description: TECHNE - Journal of Technology for Architecture and Environment, TECHNE: Special Series Vol. 1
A Small Amount of Dietary Carbohydrate Can Promote the HFD-Induced Insulin Resistance to a Maximal Level
Creators: name: Bennett, Brian J.
name: Guo, Huailan
name: Yang, Xuefeng
name: Li, Xuefeng
name: Mei, Shuang
name: Cao, Wenhong
name: Gu, Haihua
name: Cai, Junwei
name: Liu, Zhenqi
name: Zha, Longying
name: He, Ling
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Both dietary fat and carbohydrates (Carbs) may play important roles in the development of insulin resistance. The main goal of this study was to further define the roles for fat and dietary carbs in insulin resistance. C57BL/6 mice were fed normal chow diet (CD) or HFD containing 0.1–25.5% carbs for 5 weeks, followed by evaluations of calorie consumption, body weight and fat gains, insulin sensitivity, intratissue insulin signaling, ectopic fat, and oxidative stress in liver and skeletal muscle. The role of hepatic gluconeogenesis in the HFD-induced insulin resistance was determined in mice. The role of fat in insulin resistance was also examined in cultured cells. HFD with little carbs (0.1%) induced severe insulin resistance. Addition of 5% carbs to HFD dramatically elevated insulin resistance and 10% carbs in HFD was sufficient to induce a maximal level of insulin resistance. HFD with little carbs induced ectopic fat accumulation and oxidative stress in liver and skeletal muscle and addition of carbs to HFD dramatically enhanced ectopic fat and oxidative stress. HFD increased hepatic expression of key gluconeogenic genes and the increase was most dramatic by HFD with little carbs, and inhibition of hepatic gluconeogenesis prevented the HFD-induced insulin resistance. In cultured cells, development of insulin resistance induced by a pathological level of insulin was prevented in the absence of fat. Together, fat is essential for development of insulin resistance and dietary carb is not necessary for HFD-induced insulin resistance due to the presence of hepatic gluconeogenesis but a very small amount of it can promote HFD-induced insulin resistance to a maximal level.
A Small Molecule p75NTR Ligand, LM11A-31, Reverses Cholinergic Neurite Dystrophy in Alzheimer's Disease Mouse Models with Mid- to Late-Stage Disease Progression
Creators: name: Finkle, Carly
name: Massa, Stephen M.
name: Banerjee, Gargi
name: Longo, Frank M.
name: Simmons, Danielle A.
name: Belichenko, Nadia P.
name: Knowles, Juliet K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Degeneration of basal forebrain cholinergic neurons contributes significantly to the cognitive deficits associated with Alzheimer's disease (AD) and has been attributed to aberrant signaling through the neurotrophin receptor p75 (p75NTR). Thus, modulating p75NTR signaling is considered a promising therapeutic strategy for AD. Accordingly, our laboratory has developed small molecule p75NTR ligands that increase survival signaling and inhibit amyloid-β-induced degenerative signaling in in vitro studies. Previous work found that a lead p75NTR ligand, LM11A-31, prevents degeneration of cholinergic neurites when given to an AD mouse model in the early stages of disease pathology. To extend its potential clinical applications, we sought to determine whether LM11A-31 could reverse cholinergic neurite atrophy when treatment begins in AD mouse models having mid- to late stages of pathology. Reversing pathology may have particular clinical relevance as most AD studies involve patients that are at an advanced pathological stage. In this study, LM11A-31 (50 or 75 mg/kg) was administered orally to two AD mouse models, Thy-1 hAPPLond/Swe (APPL/S) and Tg2576, at age ranges during which marked AD-like pathology manifests. In mid-stage male APPL/S mice, LM11A-31 administered for 3 months starting at 6–8 months of age prevented and/or reversed atrophy of basal forebrain cholinergic neurites and cortical dystrophic neurites. Importantly, a 1 month LM11A-31 treatment given to male APPL/S mice (12–13 months old) with late-stage pathology reversed the degeneration of cholinergic neurites in basal forebrain, ameliorated cortical dystrophic neurites, and normalized increased basal forebrain levels of p75NTR. Similar results were seen in female Tg2576 mice. These findings suggest that LM11A-31 can reduce and/or reverse fundamental AD pathologies in late-stage AD mice. Thus, targeting p75NTR is a promising approach to reducing AD-related degenerative processes that have progressed beyond early stages.
A Survey on Hong Kong Secondary School Students' Knowledge of Emergency Management of Dental Trauma
Creators: name: Wong, Kin Yau
name: Cheung, Lim K.
name: Young, Cecilia
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: ObjectivesTo investigate Hong Kong secondary school students' knowledge of emergency management of dental trauma.MethodA questionnaire survey on randomly selected secondary school students using cluster sampling.ResultsOnly 36.6% (209/571) of the respondents were able to correctly identify the appropriate place for treatment of dental injury. 55.2% of the respondents knew the suitable time for treatment. Only 24.7% of the respondents possessed the knowledge of how to correctly manage fractured teeth. Only 23.6% of them knew how to manage displaced teeth. 62.5% of them correctly answered that knocked-out deciduous teeth should not be replanted to the original position, but few of them (23.6%) knew that permanent teeth should be replanted. Moreover, 37.1% of the respondents correctly identified at least one of the appropriate media for storing a knocked-out tooth. First-aid training and acquisition of dental injury information from other sources were significant factors that positive responses from these questions would lead to higher scores.ConclusionHong Kong secondary school students' knowledge of emergency management of dental trauma is considered insufficient. An educational campaign in secondary schools dedicated to students is recommended. Prior first-aid training and acquisition of dental injury information from other sources positively relate to the level of knowledge. Dental trauma emergency management is recommended to be added to first-aid publications and be taught to students and health professionals.Trial Registration: Hong Kong Clinical Trial CentreHKCTR-1344
Michael Howard and the Historian’s Craft: An Introduction to the Michael Howard Special Issue
Creators: name: Kitchen, James E
name: Mitchell, Stuart
Publisher: name: British Journal for Military History
Year: 2022

description: This introduction to the Michael Howard Special Issue offers a short background to his life, contextualises the themes found across the contributions to this issue, and then provides a more detailed analysis of Howard and his two ‘careers’ as a Captain and a Professor. Howard’s life as a soldier is too often compartmentalised from his work as a historian; this introduction examines where and how Howard’s military experiences shaped his later intellectual interests, academic career, and historiographical ideas. It then moves on to look at Howard’s landmark lecture and article ‘The Use and Abuse of Military History’, the influences on his methodology, and two prominent lectures he gave at Oxford as Regius Professor of History. The picture that emerges of Howard is one of a life dedicated to understanding the past and nurturing through good faith the generations that would follow him.
description: British Journal for Military History, Vol 8 No 2 (2022): Special Issue - Prof. Sir Michael Howard
Abriendo Puertas: Baseline Findings from an Integrated Intervention to Promote Prevention, Treatment and Care among FSW Living with HIV in the Dominican Republic
Creators: name: Perez, Martha
name: Donastorg, Yeycy
name: Barrington, Clare
name: Kerrigan, Deanna
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Female sex workers (FSW) are often the focus of primary HIV prevention efforts. However, little attention has been paid to the prevention, treatment, and care needs of FSW living with HIV. Based on formative research, we developed an integrated model to promote prevention and care for FSW living with HIV in Santo Domingo, Dominican Republic, including (1) individual counseling and education; (2) peer navigation; (3) clinical provider training; and (4) community mobilization. We enrolled 268 FSW living with HIV into the intervention and conducted socio-behavioral surveys, sexually transmitted infection (STI) testing, and viral load (VL) assessments. We used multivariate logistic regression to identify behavioral and socio-demographic factors associated with detectable VL (>50 copies/mL) and STI prevalence. Over half of all participants (51.9%) had a detectable VL, even though most received HIV-related care in the last 6 months (85.1%) and were currently on anti-retroviral treatment (ART) (72.4%). Factors positively associated with a detectable VL included being 18–35 years of age (Adjusted Odds Ratio [AOR] 2.46, 95% CI 1.31–4.60), having ever used drugs (AOR 2.34, 95% CI 1.14–4.79), and having ever interrupted ART (AOR 3.09, 95% CI 1.44–6.59). Factors protective against having a detectable VL included being single (AOR 0.45, 95% 0.20–0.98) and being currently on ART (AOR 0.17, 95% CI 0.07–0.41). Nearly one-quarter (23.1%) had an STI, which was associated with being single (AOR 3.21, 95% CI 1.27–8.11) and using drugs in the last 6 months (AOR 3.54, 95% CI 1.32–9.45). Being on ART was protective against STI (AOR 0.51, 95% CI 0.26–1.00). Baseline findings indicate significant barriers to VL suppression and STI prevention among FSW living with HIV and highlight gaps in the continuum of HIV care and treatment. These findings have important implications for both the individual health of FSW and population-level HIV transmission dynamics.
Numerical simulations of bonded post-tensioned concrete bridge girders under hydrocarbon fire
Creators: name: Wu, Xiqiang
name: Huang, Ting
name: Au, Francis Tat Kwong
Publisher: name: figshare
Year: 2023
Subjects: Fire safety engineering

description: A sequentially coupled 3-step modelling approach is adopted to study the failure mechanism of bonded post-tensioned concrete bridges under hydrocarbon fire. Firstly, a furnace fire model was built and solved. The adiabatic surface temperature (AST) obtained from fire modelling was then applied on the surfaces of the finite element model of the structure to determine the inner temperature field. Finally, the structural response under full range of fire was analysed based on this temperature field. It is noting that the bonding layer between strand and surround grout was modelled at both grouting and fire stages. Special attention was paid to the establishment of the furnace fire model. The calibrated models can be used for estimating the results of new fire tests. The numerical models were validated by fire tests on six scaled bridge beams. Results shows that the fire resistance of prestressed concrete structures depends largely on the strand temperature. In comparison, the box-section bridge beams have better fire resistance than the tee-section bridge beams.
Deuteration and evolution in the massive star formation process: the role of surface chemistry
Creators: name: Fontani, F.
name: Busquet, G.
name: Palau, Aina
name: Caselli, P.
name: A.
name: Sanchez-Monge
name: Tan, J. C.
name: Audard, M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: An ever growing number of observational and theoretical evidence suggests that the deuterated fraction (column density ratio between a species containing D and its hydrogenated counterpart, Dfrac) is an evolutionary indicator both in the low- and the high-mass star formation process. However, the role of surface chemistry in these studies has not been quantified from an observational point of view. In order to compare how the deuterated fractions of species formed only in the gas and partially or uniquely on grain surfaces evolve with time, we observed rotational transitions of CH3OH, 13CH3OH, CH2DOH, CH3OD at 3 and 1.3~mm, and of NH2D at 3~mm with the IRAM-30m telescope, and the inversion transitions (1,1) and (2,2) of NH3 with the GBT, towards most of the cores already observed by Fontani et al.~(2011, 2014) in N2H+, N2D+, HNC, DNC. NH2D is detected in all but two cores, regardless of the evolutionary stage. Dfrac(NH3) is on average above 0.1, and does not change significantly from the earliest to the most evolved phases, although the highest average value is found in the protostellar phase (~0.3). Few lines of CH2DOH and CH3OD are clearly detected, and only towards protostellar cores or externally heated starless cores. This work clearly confirms an expected different evolutionary trend of the species formed exclusively in the gas (N2D+ and N2H+) and those formed partially (NH2D and NH3) or totally (CH2DOH and CH3OH) on grain mantles. The study also reinforces the idea that Dfrac(N2H+) is the best tracer of massive starless cores, while high values of Dfrac(CH3OH) seem rather good tracers of the early protostellar phases, at which the evaporation/sputtering of the grain mantles is most efficient.
description: 14 pages, 7 figures, 2 Appendices
Age-Dependent Male Mating Investment in Drosophila pseudoobscura
Creators: name: Pfennig, Karin S.
name: Dhole, Sumit
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Male mating investment can strongly influence fitness gained from a mating. Yet, male mating investment often changes with age. Life history theory predicts that mating investment should increase with age, and males should become less discriminatory about their mate as they age. Understanding age-dependent changes in male behavior and their effects on fitness is important for understanding how selection acts in age-structured populations. Although the independent effects of male or female age have been studied in many species, how these interact to influence male mating investment and fitness is less well understood. We mated Drosophila pseudoobscura males of five different age classes (4-, 8-, 11-, 15-, 19-day old) to either young (4-day) or old (11-day) females, and measured copulation duration and early post-mating fecundity. Along with their independent effects, we found a strong interaction between the effects of male and female ages on male mating investment and fitness from individual matings. Male mating investment increased with male age, but this increase was more prominent in matings with young females. Male D. pseudoobscura made smaller investments when mating with old females. The level of such discrimination based on female age, however, also changed with male age. Intermediate aged males were most discriminatory, while the youngest and the oldest males did not discriminate between females of different ages. We also found that larger male mating investments resulted in higher fitness payoffs. Our results show that male and female ages interact to form a complex pattern of age-specific male mating investment and fitness.
War, Technology and Narrative Hierarchies
Creators: name: Miller, Alisa
Publisher: name: British Journal for Military History
Year: 2022

description: This article considers some of the ways communications technologies have shaped narratives of war. It touches on different military cultures and how they contend with imposed and implicit hierarchies. It then goes on to briefly discuss the ways these hierarchies are expressed in various analogue and online media, both as a reflection and a potential subverter of cultural expectations about who participates in conflicts, and how.
description: British Journal for Military History, Vol 8 No 2 (2022): Special Issue - Prof. Sir Michael Howard
Allogeneic Cardiospheres Delivered via Percutaneous Transendocardial Injection Increase Viable Myocardium, Decrease Scar Size, and Attenuate Cardiac Dilatation in Porcine Ischemic Cardiomyopathy
Creators: name: Dharmakumar, Rohan
name: Duong, Doan Trang
name: Ho, Chak-Sum
name: Malliaras, Konstantinos
name: Marbán, Linda
name: Yee, Kristine
name: Seinfeld, Jeffrey
name: Dawkins, James F.
name: Li, Debiao
name: Marbán, Eduardo
name: Middleton, Ryan C.
name: Takayama, Kentaro
name: Luthringer, Daniel J.
name: Tseliou, Eleni
name: Cheng, Ke
name: Kanazawa, Hideaki
name: Makkar, Raj R.
name: Chowdhury, Supurna
name: Minamino, Naoto
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: BackgroundEpicardial injection of heart-derived cell products is safe and effective post-myocardial infarction (MI), but clinically-translatable transendocardial injection has never been evaluated. We sought to assess the feasibility, safety and efficacy of percutaneous transendocardial injection of heart-derived cells in porcine chronic ischemic cardiomyopathy.Methods and ResultsWe studied a total of 89 minipigs; 63 completed the specified protocols. After NOGA-guided transendocardial injection, we quantified engraftment of escalating doses of allogeneic cardiospheres or cardiosphere-derived cells in minipigs (n = 22) post-MI. Next, a dose-ranging, blinded, randomized, placebo-controlled (“dose optimization”) study of transendocardial injection of the better-engrafting product was performed in infarcted minipigs (n = 16). Finally, the superior product and dose (150 million cardiospheres) were tested in a blinded, randomized, placebo-controlled (“pivotal”) study (n = 22). Contrast-enhanced cardiac MRI revealed that all cardiosphere doses preserved systolic function and attenuated remodeling. The maximum feasible dose (150 million cells) was most effective in reducing scar size, increasing viable myocardium and improving ejection fraction. In the pivotal study, eight weeks post-injection, histopathology demonstrated no excess inflammation, and no myocyte hypertrophy, in treated minipigs versus controls. No alloreactive donor-specific antibodies developed over time. MRI showed reduced scar size, increased viable mass, and attenuation of cardiac dilatation with no effect on ejection fraction in the treated group compared to placebo.ConclusionsDose-optimized injection of allogeneic cardiospheres is safe, decreases scar size, increases viable myocardium, and attenuates cardiac dilatation in porcine chronic ischemic cardiomyopathy. The decreases in scar size, mirrored by increases in viable myocardium, are consistent with therapeutic regeneration.
Contribución al estudio de la distribución e incidencia de parasitismo de Hemioniscus balani (Isopoda, Epicaridea, Cryptoniscidae) sobre la población de Chthalamus fissus (Cirripedia, Chthamalidae), en Baja California, México /
Creators: name: Guerrero Villalvazo, Magdaleno.
Publisher: name: Universidad Autónoma de Baja California, Ensenada.
Year: 2023
Subjects: subject: Oceanología||Tesis y disertaciones académicas||Ecología||Parasitismo invertebrados.
subject: QH547 G84 1987

description: El presente trabajo extiende el rango de distribución del parásito Hemioniscus balani desde Punta Morro, Bahía Todos Santos, hasta el ejido nativos del valle de Mexicali, Santo Tomás, B.C.
New natural shapes of non-Gaussianity from high-derivative interactions and their optimal limits from WMAP 9-year data
Creators: name: Behbahani, Siavosh R.
name: Mirbabayi, Mehrdad
name: Senatore, Leonardo
name: Smith, Kendrick M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Given the fantastic experimental effort, it is important to thoroughly explore the signature space of inflationary models. The fact that higher derivative operators do not renormalize lower derivative ones allows us to find a large class of technically natural single-clock inflationary models where, in the context of the Effective Field Theory of Inflation, the leading interactions have many derivatives. We systematically explore the 3-point function induced by these models and their overlap with the standard equilateral and orthogonal templates. We find that in order to satisfactorily cover the signature space of these models, two new additional templates need to be included. We then perform the optimal analysis of the WMAP 9-year data for the resulting four templates, finding that the overall significance of a non-zero signal is between 2--2.5$σ$, depending on the choice of parameter space, partially driven by the preference for nonzero $f_{NL}^{\rm orth}$ in WMAP9.
description: 22+14 pages,
Les orientations et les recours dans Makasi : résultats préliminaires
Creators: name: Eid, Julia
Publisher: name: Zenodo
Year: 2020

description: Ce premier bilan de l’intervention Makasi a permis de décrire vers quels types de structures les participants sont orientés et quels types de recours ils entreprennent. Pour cela, une description des besoins identifiés et des orientations faites à l’issue de l’entretien a été réalisée, ainsi qu’une comparaison des recours entrepris lors des 3 derniers mois écoulés par les participants entre le moment de leur inclusion dans Makasi et 3 mois après l’intervention. Les résultats montrent que l’intervention déclenche un recours aux professionnels de santé et au travailleur social par les participants. À l’inverse, les démarches administratives avaient été engagées par les participants avant même leur inclusion dans Makasi. L’intervention Makasi est un levier intéressant pour l’accès aux professionnels de santé et au travailleur social, intervenant également sur une forme de prise de conscience des besoins de santé et de prévention par les participants.
Image patch analysis and clustering of sunspots: a dimensionality reduction approach
Creators: name: Moon, Kevin R.
name: Li, Jimmy J.
name: Delouille, Veronique
name: Watson, Fraser
name: Hero, Alfred O.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: Sunspots, as seen in white light or continuum images, are associated with regions of high magnetic activity on the Sun, visible on magnetogram images. Their complexity is correlated with explosive solar activity and so classifying these active regions is useful for predicting future solar activity. Current classification of sunspot groups is visually based and suffers from bias. Supervised learning methods can reduce human bias but fail to optimally capitalize on the information present in sunspot images. This paper uses two image modalities (continuum and magnetogram) to characterize the spatial and modal interactions of sunspot and magnetic active region images and presents a new approach to cluster the images. Specifically, in the framework of image patch analysis, we estimate the number of intrinsic parameters required to describe the spatial and modal dependencies, the correlation between the two modalities and the corresponding spatial patterns, and examine the phenomena at different scales within the images. To do this, we use linear and nonlinear intrinsic dimension estimators, canonical correlation analysis, and multiresolution analysis of intrinsic dimension.
description: 5 pages, 7 figures, accepted to ICIP 2014
Evaluación de actividad anti proliferativa y efecto citotóxico de nanopartículas de plata (AGNPS) en la línea celular de cáncer de mamá triple negativo mda-mb-231
Creators: name: Juárez Herrera, Karla Iliana.
Publisher: name: Universidad Autónoma de Baja California, Ensenada.
Year: 2023
Subjects: subject: Ingeniería||Tesis y disertaciones académicas||Metales en medicina
subject: RM666.M513 J83 2022

description: En la actualidad el uso de la nanotecnología se plantea como una alternativa en diferentes industrias.
Allogeneic Splenocyte Transfer and Lipopolysaccharide Inhalations Induce Differential T Cell Expansion and Lung Injury: A Novel Model of Pulmonary Graft-versus-Host Disease
Creators: name: Kelly, Francine L.
name: Sun, Jesse
name: Nelson, Margaret E.
name: Garantziotis, Stavros
name: Martinu, Tereza
name: Foster, W. Michael
name: Palmer, Scott M.
name: Kinnier, Christine V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: BackgroundPulmonary GVHD (pGVHD) is an important complication of hematopoietic cell transplant (HCT) and is thought to be a consequence of the HCT conditioning regimen, allogeneic donor cells, and posttransplant lung exposures. We have previously demonstrated that serial inhaled lipopolysaccharide (LPS) exposures potentiate the development of pGVHD after murine allogeneic HCT. In the current study we hypothesized that allogeneic lymphocytes and environmental exposures alone, in the absence of a pre-conditioning regimen, would cause features of pGVHD and would lead to a different T cell expansion pattern compared to syngeneic cells.MethodsRecipient Rag1−/− mice received a transfer of allogeneic (Allo) or syngeneic (Syn) spleen cells. After 1 week of immune reconstitution, mice received 5 daily inhaled LPS exposures and were sacrificed 72 hours after the last LPS exposure. Lung physiology, histology, and protein levels in bronchoalveolar lavage (BAL) were assessed. Lung cells were analyzed by flow cytometry.ResultsBoth Allo and Syn mice that undergo LPS exposures (AlloLPS and SynLPS) have prominent lymphocytic inflammation in their lungs, resembling pGVHD pathology, not seen in LPS-unexposed or non-transplanted controls. Compared to SynLPS, however, AlloLPS have significantly increased levels of BAL protein and enhancement of airway hyperreactivity, consistent with more severe lung injury. This injury in AlloLPS mice is associated with an increase in CD8 T cells and effector CD4 T cells, as well as a decrease in regulatory to effector CD4 T cell ratio. Additionally, cytokine analysis is consistent with a preferential Th1 differentiation and upregulation of pulmonary CCL5 and granzyme B.ConclusionsAllogeneic lymphocyte transfer into lymphocyte-deficient mice, followed by LPS exposures, causes features of pGVHD and lung injury in the absence of a pre-conditioning HCT regimen. This lung disease associated with an expansion of allogeneic effector T cells provides a novel model to dissect mechanisms of pGVHD independent of conditioning.
Cambios estacionales de las variables oceanográficas físicas y biogeoquímicas de cinco campañas durante el período 2019-2020 en la laguna costera de Bahía San Quintín, Baja California, México
Creators: name: Yacini Torres, Safia Celeste.
Publisher: name: Universidad Autónoma de Baja California, Ensenada.
Year: 2023
Subjects: Oceanografía||Tesis y disertaciones académicas||Costas México.

description: El estudio de las variables físicas y biogeoquímicas dentro de las lagunas costeras, nos permite conocer mejor la relación que hay entre estas y su intercambio con el océano adyacente.