Metadata supporting the article: Accuracy of Breast MRI in Evaluating Nodal Status After Neoadjuvant Therapy in Invasive Lobular Carcinoma
Creators: name: Abel, Mary Kathryn
name: Greenwood, Heather
name: Kelil, Tatiana
name: Guo, Ruby
name: Case Brabham
name: Hylton, Nola
name: Wong, Jasmine
name: Alvarado, Michael
name: Ewing, Cheryl
name: Esserman, Laura J.
name: Boughey, Judy C.
name: Mukhtar, Rita A.
Publisher: name: figshare
Year: 2021
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: FOS: Biological sciences
subject: Cancer
subject: Medicine
subject: 111202 Cancer Diagnosis
subject: FOS: Clinical medicine
subject: FOS: Clinical medicine
subject: 111205 Chemotherapy

description: Neoadjuvant therapy in breast cancer can downstage axillary lymph nodes and reduce extent of axillary surgery. As such, accurate determination of nodal status after neoadjuvant therapy and before surgery impacts surgical management. There are scarce data on the diagnostic accuracy of breast magnetic resonance imaging (MRI) for nodal evaluation after neoadjuvant therapy in patients with invasive lobular carcinoma (ILC), a diffusely growing tumor type. In this study, the authors evaluated a cohort of ILC patients treated with either neoadjuvant chemotherapy or endocrine therapy and determined the accuracy of post-treatment MRI for predicting pathologic nodal status in both clinically node negative and clinically node positive patients.<br> <b>Data access</b>: The data that support the findings of this study, contain clinical outcomes for which IRB requires approval prior to analysis. Therefore, the data are not publicly available. The data will be made available to authorized researchers who have obtained institutional review board (IRB) approval from their own institution and from the University of California, San Francisco (UCSF) IRB. For data access requests, please contact the corresponding author, Dr. Rita Mukhtar, email address: rita.mukhtar@ucsf.edu. <br> <b>Study approval</b>: This retrospective study was approved by the UCSF Institutional Review Board.<br> <b>Study aims and methodology: </b>In this study, the authors evaluated the performance of breast MRI in predicting the status of axillary nodes in the setting of either neoadjuvant chemotherapy or neoadjuvant endocrine therapy, in a cohort of patients with ILC. The study used data from 79 patients. The authors retrospectively analyzed patients with stage 1-3 ILC who underwent pre-operative breast MRI after either neoadjuvant chemotherapy or endocrine therapy at the University of California, San Francisco, between 2006-2019. Two breast radiologists reviewed MRIs and evaluated axillary nodes for suspicious features. All patients underwent either sentinel node biopsy or axillary dissection. The authors evaluated sensitivity, specificity, negative and positive predictive values, and overall accuracy of the post-treatment breast MRI in predicting pathologic nodal status. For more details on the methodology, please refer to the related article.<br> <b>Data supporting the figures and tables</b>: Dataset <b>ILC database 6.28.19.xls</b> is in .xls file format and supports figure 1 and tables 1-4 in the related article.