cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Implementing a Reverse Dictionary, based on word definitions, using a Node-Graph Architecture
Creators: name: Thorat, Sushrut
name: Choudhari, Varad
Publisher: name: arXiv
Year: 2016
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences
subject: I.2.7

description: In this paper, we outline an approach to build graph-based reverse dictionaries using word definitions. A reverse dictionary takes a phrase as an input and outputs a list of words semantically similar to that phrase. It is a solution to the Tip-of-the-Tongue problem. We use a distance-based similarity measure, computed on a graph, to assess the similarity between a word and the input phrase. We compare the performance of our approach with the Onelook Reverse Dictionary and a distributional semantics method based on word2vec, and show that our approach is much better than the distributional semantics method, and as good as Onelook, on a 3k lexicon. This simple approach sets a new performance baseline for reverse dictionaries.
description: Included publication information
More Goosebumps : authorial impositions in popular fantasy/horror fiction written 'for' children
Creators: name: Coppell, Vicki.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Enter "Exalted guest" : the role of the music in an Indonesian feature film of 1955
Creators: name: Gunn, Malcolm.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Zur Praxis des elektronischen Publizierens an der Hochschule: Textformate, Grafikformate
Creators: name: Braun, Kim
name: Liebetruth, Martin
Publisher: name: Univ
Year: 2002
Subjects: subject: 020

description: In diesem Tutorium soll der Weg einer Publikation ins Leben auf dem www beschrieben werden. Neben grundsätzlichen Bedingungen zur Veröffentlichung einer online-Publikation wird an einem Beispiel Schritt für Schritt eine mögliche Vorgehensweise geschildert und dargestellt, eine Publikation im www zu veröffentlichen. Das Spektrum der Publikationen kann dabei von der online-Dissertation über andere wissenschaftliche Beiträge bis hin zum Vorlesungsverzeichnis oder Unterrichtsmaterial reichen. In dem Tutorium wird weniger das Schreiben einer html-Seite als vielmehr die Erstellung eines pdf-Dokuments im Vordergrund stehen. Dabei soll auf verschiedene Punkte eingegangen werden: Anlieferungsformate, benötigte Software, Möglichkeiten des Konvertierens, Wandelns und Bearbeitens der Dateien, Dateigrößen, Darstellung auf dem Server usw. Selbstverständlich wird gezeigt, wie prima das alles funktioniert, aber auch immer wieder auftauchende Probleme sollen erwähnt und mit den Teilnehmern besprochen werden. Erfahrungen, Probleme und Lösungsansätze für diese sollen im aktiven Dialog miteinander ausgetauscht werden. Besondere Vorkenntnisse sind für dieses Tutorium nicht erforderlich.
Avalanches and force drops in displacement-driven compression of porous glasses
Creators: name: Navas-Portella, Víctor
name: Corral, Álvaro
name: Vives, Eduard
Publisher: name: arXiv
Year: 2016
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Similarities between force-driven compression experiments of porous materials and earthquakes have been recently proposed. In this manuscript, we measure the acoustic emission during displacement-driven compression of a porous glass. The energy of acoustic-emission events shows that the failure process exhibits avalanche scale-invariance and therefore follows the Gutenberg-Richter law. The resulting exponents do not exhibit significant differences with respect the force-driven case. Furthermore, the force exhibits an avalanche-type behaviour for which the force drops are power-law distributed and correlated with the acoustic emission events.
description: 18 pages, 8 figures
An analysis of two fuel moisture models and their application in wet sclerophyll forests
Creators: name: Maughan, Duncan P. C.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
More than a meal : a cross-generational study of an Australian family's food habits
Creators: name: Grant, Marla Boye.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
title: Problemorientierte Lernumgebungen im Eingangsstudium des Faches Chemie
title: Entwicklung und Fallstudienevaluation am Beispiel der Lehrveranstaltrung Allgemeine und Experimentelle Chemie an der Ruhr-Universität Bochum
titleType: AlternativeTitle
Creators: name: Ruttert, Matthias
Publisher: name: Universität Dortmund
Year: 2002
Subjects: subject: Problemorientiertes Lernen
subject: Situiertes Lernen
subject: Lernen im Kontext
subject: Authentisches Lernen
subject: Träges Wissen
subject: Konstruktivistische Lehr- und Lernansätze
subject: Metakognitive Kontrollstrategien
subject: Projektarbeit
subject: Prozessorientierte Lernumgebungen
subject: Gruppendiskussionen am Experiment
subject: Concept Maps
subject: Problemzentrierte Interviews
subject: 370

description: Aufbauend auf Theorien und Ansätzen des 'situierten Lernens' wurde für das Eingangsstudium im Fach Chemie an der Ruhr-Universität Bochum ein Curriculum konzipiert, in dem die Studierenden in problemorientierten Lernumgebungen flexibel anwendbares Wissen erwerben sollen, das sie zu einem kompetenten Handeln befähigt. Kernidee dieses problemorientierten Curriculums ist, dass die Lernenden schon zu Beginn des Studiums - und nicht erst in der Abschlussphase ihres Studiums - lernen, komplexe und authentische Problemstellungen selbständig zu bearbeiten. Die Problemstellungen zeichnen sich dadurch aus, dass ihre Komplexität im Laufe der Lehrveranstaltung zunimmt und nicht bereits im Vorfeld durch den Lehrenden reduziert wurde - auf diese Weise bieten die Problemstellungen mehrere alternative Lösungswege. Authentizität bedeutet, dass die kognitiven Prozesse, die die Lernenden bei der Lösung der Problemstellungen anwenden, denen bei der Lösung realer Probleme entsprechen. Die Lernenden müssen das Problem in sinnvolle Teilprobleme zerlegen, mit anderen Studierenden über Schwierigkeiten diskutieren, Ergebnisse aus- und bewerten und veröffentlichen.Den Erwerb solchen 'intelligenten Wissens' zu unterstützen, ist nicht trivial: Es gilt, eine Balance zwischen der notwendigen (Lerner-)Konstruktion und der wohlorganisierten (Lehrer-)Instruktion zu finden. Mit Hilfe prozessorientierter Evaluationsmethoden soll untersucht werden, inwieweit durch dieses Curriculum der Erwerb flexibel anwendbaren chemischen Wissens und chemischer Strategien tatsächlich gefördert werden kann und inwieweit die Lernenden ihr Handeln durch metakognitive Strategien kontrollieren.
Amtliche Mitteilungen der Technischen Universität Dortmund Nr. 2/2008
Creators: name: (:Unkn) Unknown
Publisher: name: Technische Universität Dortmund
Year: 2008
Subjects: subject: 080

description: Grundsätze für studienbegleitende Prüfungsverfahren der Technischen Universität Dortmund
description: Promotionsordnung der Technischen Universität Dortmund für die Fakultät Erziehungswissenschaften und Soziologie vom 1. Februar 2008
description: Prüfungsordnung zum Studiengang Bachelor of Science in Chemie an der Technischen Universität Dortmund vom 30. Januar 2008
description: Prüfungsordnung zum Studiengang Bachelor of Science in Chemischer Biologie an der Technischen Universität Dortmund vom 30. Januar 2008
description: Studienordnung für den Bachelor-Studiengang Chemie an der Technischen Universität Dortmund vom 30. Januar 2008
description: Studienordnung für den Bachelor-Studiengang Chemische Biologie an der Technischen Universität Dortmund vom 30. Januar 2008
description: Verwaltungs- und Benutzungsordnung des Zentrums für Weiterbildung der Technischen Universität Dortmund
description: Amtliche Mitteilungen der Technischen Universität Dortmund ; 2, 2008
ENLACE: Recruitment and Screening Forms
Creators: name: Institute, Latino Research
Publisher: name: The University of Texas at Austin
Year: 2023
Subjects: Enlace
Latino
Latina
Hispanic
women
promotora
community outreach
physical activity
border
rural
exercise
fitness
South Texas
screening
recruitment
script

description: The study “ENLACE: A Promotora-Led Physical Activity Intervention Trial for Latinas in Texas” is a clinical trial (NCT00869583) funded by the National Institute of Health (NIH) (R01HL111718).
description: Forms used to screen and recruit participants for the Enlace study. This includes an initial contact form, participant communication log, and appointment log (all in Spanish), as well as eligibility screenings scripts and forms (in English and Spanish).
Amtliche Mitteilungen der Technischen Universität Dortmund Nr. 03/2014
Creators: name: (:Unkn) Unknown
Publisher: name: Technische Universität Dortmund
Year: 2014
Subjects: subject: 080

description: Richtlinie für die Erteilung und Vergütung von Lehraufträgen an der Technischen Universität Dortmund
description: Amtliche Mitteilungen der Technischen Universität Dortmund ; 3, 2014
title: Investigation of local minima in autonomous potential field agents/vehicles in pure dynamic environment
Creators: name: Statheros, Thomas
Publisher: name: University of Kent
Year: 2023

description: Autonomous vehicle navigation can be divided into two major areas of research: Collision avoidance and Track-Keeping. This study focuses on Collision avoidance which is one of the major issues that unmanned autonomous vehicles have to face. Collision avoidance may be further grouped into classical and soft computing based categories. Classical techniques are based on mathematical models and algorithms, while soft-computing techniques are based on Artificial Intelligence. In this study, we focus on the Classical techniques and more specifically in the Potential Field Methods. The potential field algorithms rapidly gained popularity due to their simplicity and elegance. In other words, Potential Field Methods are generic, computationally efficient and generate naturally smooth trajectories. On the other hand, PFM algorithms experience local minima. Nevertheless, local minima for PFM are extensively studied in different environments; they have never studied in a Pure Dynamic Environment (PDE). PDE is a new dynamic environment in which all its elements are guaranteed to be dynamic at their initial state. In this way we have managed to identify and define the causes of Potential Field Agent local minima and trajectory inefficiencies in a number of collision scenarios within PDE. To efficiently and accurately identify and define these causes of local minima and traj ectory inefficiencies, we have introduced the novel concept of the Monovular Autonomous Agent Correlation. Based on this concept we have identified and mathematically defined the Trajectory Equilibrium State (TES) for the first time. This state is responsible for local minima and trajectory inefficiencies of Monovular Autonomous Agents in PDE. Because of TES identification and definition we have designed a lUle based mathematical algorithm that efficiently navigates the Autonomous Agents out of local minima and trajectory inefficiencies in PDE in a number of generic collision scenarios. The algorithm's performance is tested in a number of simulated water based collision scenarios.
Supporting material for a PubPeer comment on Blasco-Moreno et al. (2019)
Creators: name: Totterman, Stephen
Publisher: name: Zenodo
Year: 2023

description: Three figures and R code (https://www.r-project.org/) supporting material for a PubPeer comment on: Blasco‐Moreno A., Pérez‐Casany M., Puig P., Morante M. & Castells E. (2019). What does a zero mean? Understanding false, random and structural zeros in ecology. Methods in Ecology and Evolution 10: 949–959. https://doi.org/10.1111/2041-210X.13185 The data is available at https://ddd.uab.cat/record/194390 One can read the comment by searching for the above DOI on https://pubpeer.com/
On the Lack of a Radio Afterglow from Some Gamma-ray Bursts - Insight into Their Progenitors?
Creators: name: Lloyd-Ronning, Nicole M.
name: Fryer, Christopher L.
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We investigate the intrinsic properties of a sample of bright (E_iso > 10^52 erg) gamma-ray bursts, comparing those with and without radio afterglows. We find that the sample of bursts with no radio afterglows has a significantly shorter mean intrinsic duration of the prompt gamma-ray radiation, and the distribution of this duration is significantly different from those bursts with a radio afterglow. Although the sample with no radio afterglow has on average lower isotropic energy, the lack of radio afterglow does not appear to be a result of simply energetics of the burst, but a reflection of a separate physical phenomenon likely related to the circumburst density profile. We also find a weak correlation between the isotropic gamma-ray energy and intrinsic duration in the sample with no radio afterglow, but not in the sample which have observed radio afterglows. We give possible explanations for why there may exist a sample of GRBs with no radio afterglow depending on whether the radio emission comes from the forward or reverse shock, and why these bursts appear to have intrinsically shorter prompt emission durations. We discuss how our results may have implications for progenitor models of GRBs.
description: Final version, accepted to MNRAS
Cantharidin and Its Analogue Norcantharidin Inhibit Metastasis—Inducing Genes S100A4 and MACC1
Creators: name: Schöpe, Paul Curtis
name: Zinnow, Viktoria
name: Ishfaq, Muhammad Ahtisham
name: Smith, Janice
name: Herrmann, Pia
name: Shoemaker, Robert H.
name: Walther, Wolfgang
name: Stein, Ulrike
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2023
Subjects: subject: colorectal cancer
subject: metastasis
subject: MACC1
subject: cantharidin
subject: norcantharidin
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Colorectal cancer (CRC) is the third most prevalent and second deadliest cancer worldwide. In addition, metastasis directly causes up to 90% of all CRC deaths, highlighting the metastatic burden of the disease. Biomarkers such as S100A4 and MACC1 aid in identifying patients with a high risk of metastasis formation. High expression of S100A4 or MACC1 and to a greater extent the combination of both biomarkers is a predictor for metastasis and poor patient survival in CRC. MACC1 is a tumor-initiating and metastasis-promoting oncogene, whereas S100A4 has not been shown to initiate tumor formation but can, nevertheless, promote malignant tumor growth and metastasis formation. Cantharidin is a natural drug extracted from various blister beetle species, and its demethylated analogue norcantharidin has been shown in several studies to have an anti-cancer and anti-metastatic effect in different cancer entities such as CRC, breast cancer, and lung cancer. The impact of the natural compound cantharidin and norcantharidin on S100A4 and MACC1 gene expression, cancer cell migration, motility, and colony formation in vitro was tested. Here, for the first time, we have demonstrated that cantharidin and norcantharidin are transcriptional inhibitors of S100A4 and MACC1 mRNA expression, protein expression, and motility in CRC cells. Our results clearly indicate that cantharidin and, to a lesser extent, its analogue norcantharidin are promising compounds for efficient anti-metastatic therapy targeting the metastasis-inducing genes S100A4 and MACC1 for personalized medicine for cancer patients.
title: Entrepreneurial networks in backpacker businesses in Mexico and Malaysia
Creators: name: Fricke, Jörn
Publisher: name: University of Kent
Year: 2023

description: Backpacker tourism, as a niche market of international tourism, is experiencing on-going signs of massification and commodification, and it is served by entrepreneurs with a variety of business motivations that range from lifestyle-orientation to profit-motivation. Since its beginnings in the 1970s, increasing numbers of former backpackers have turned from consumers to producers of tourist services and resettled into popular destinations - often into so-called 'backpacker enclaves'. In these enclaves, they open small accommodation facilities or other services, but little is known about the development of backpacker supply services. While network analysis has been applied in a variety of academic research areas, in the field of tourism studies, the study of networks has not been applied to backpacker tourism and its service providers. The subject of this research is therefore to shed light on the changing dynamics of social, communication and exchange networks between providers and consumers of services in the context of increasingly commoditised backpacker tourism. In two well-established urban and two rural backpacker destinations in Mexico and Malaysia, in-depth interviews were held with backpacker entrepreneurs. Both countries have a history of backpacker tourism since the 1960s and are located on regional backpacker trails. This research has shown that there the nature of backpacker tourism and its services is a reaction to the changing composition of the backpacker market and regulatory framework. Strategic skills in backpacker services that used to be acquired through strong social networks between hosts and guests have changed to exchange networks between growth oriented service providers and consumers. In Malaysia, as a result of weaker social and stronger exchange networks, the entrepreneurs' knowledge and innovation is now often acquired by means of copying other businesses approaches. In these highly commoditised and concentrated backpacker enclaves, the result is a strong division between producers and consumers, while in dispersed enclaves such as in the urban enclave of San Cristobal de las Casas, where backpackers spend extended amounts of time and lifestyle, entrepreneurs-run businesses, social networks between producers and consumers of backpacker services continue to thrive. As a result, not only are social networks stronger, allowing backpacker services to continue to innovate, but lifestyle entrepreneurs continue to run businesses successfully, and the division between producer and consumer is less clear. Network analysis has proven to be a useful tool to explain the dynamics of the commodification of backpacker services, and with increasing commodification, the shift from social to exchange networks give insight into the development of backpacker tourist services, its massification and the reaction of service providers to that change.
Core Formation in Asymmetric Deterring Groups
Creators: name: Melin, John
Publisher: name: University of Chicago
Year: 2022
Subjects: subject: Deterrence
subject: Cooperation
subject: Multilateralism
subject: Core Formation
subject: Asymmetric Alliances

description: This paper studies a cooperative model of multilateral deterrence with a focus on how parametric heterogeneities in the deterring group affect core formation. Alongside basic analysis, two notably contrasting results are derived. First, it is shown that no parametrically symmetric deterring group of size n>=4 can support a core allocation. Second, a sufficient condition for core existence is derived for "single-differing-agent" groups (groups in which all agents except one outlier are parametrically identical up to a positive scale factor) which does not depend upon the specific nature of the individual non-outliers, and thus holds for groups of arbitrarily large size. Finally, computational analysis of this condition is used to show that it holds in many cases in which the outlier is sufficiently dominant in either retaliatory capability or incentive to deter.
Percy Grainger : champion of the wind band : a study of the contribution of Percy Aldridge Grainger to the repertory of the contemporary wind band, including an examination, interpretive analysis and performance of selected works from Grainger's "Chosen gems for winds"
Creators: name: Carpenter, Stephen .
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
A large-scale disturbance mapping ensemble through data-driven regionalization
Creators: name: Bueno, Inacio Thomaz
name: Hird, Jennifer
name: McDermid, Gregory John
name: Galvão, Lênio Soares
name: Júnior, Fausto Weimar Acerbi
Publisher: name: Taylor & Francis
Year: 2023
Subjects: classificationCode: 59999
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
classificationCode: 80699
subject: Information Systems not elsewhere classified
subject: Plant Biology
subject: Computational Biology

description: Mapping and monitoring disturbances in vegetation over large areas demand reliable approaches and accurate end-user maps. Methods and algorithms have been developed to meet satisfactory disturbance map accuracies, and the combination of multiple approaches has shown promise as a reliable alternative to any single method. However, extracting meaningful disturbance information from these combined methods is still challenging. Data variance from environmental conditions and disturbance drivers leads to spatial-temporal heterogeneity in land surfaces over large areas, which results in mapping errors. We evaluated the effectiveness of ensemble classification and data-driven regionalization for mapping vegetation disturbances at a broad scale. Using Google’s Earth Engine cloud computing platform, our ensemble approach combines multispectral LandTrendr outputs reflecting preliminary disturbance information in a Random Forest model to map disturbances in Minas Gerais, Brazil. We then applied an unsupervised clustering technique to perform data-driven regionalization of our study area using several sources of environmental and anthropogenic information and analysed gains and losses in map accuracies. Our results indicated gains in accuracy by the ensemble method compared to non-ensemble methods of disturbance mapping, which ranged from 7.3 to 29.9% in overall accuracy at the 5% significance level. Data-driven regionalization addressed complexities arising from variability in vegetation types, local climate, and topography across our study area, identifying climate and seasonal metrics as important variables for reducing uncertainties in vegetation disturbance maps. The integration of these techniques has revealed significant potential for increasing map accuracy and has provided important insights into the development of disturbance mapping methods in heterogeneous environments.
The Role of the Gut Microbiome and Trimethylamine Oxide in Atherosclerosis and Age-Related Disease
Creators: name: El Hage, Racha
name: Al-Arawe, Nada
name: Hinterseher, Irene
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2023
Subjects: subject: gut microbiome
subject: atherosclerosis
subject: TMAO
subject: aging
subject: gut dysbiosis
subject: probiotics
subject: short chain fatty acids
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: The gut microbiome plays a major role in human health, and gut microbial imbalance or dysbiosis is associated with disease development. Modulation in the gut microbiome can be used to treat or prevent different diseases. Gut dysbiosis increases with aging, and it has been associated with the impairment of gut barrier function leading to the leakage of harmful metabolites such as trimethylamine (TMA). TMA is a gut metabolite resulting from dietary amines that originate from animal-based foods. TMA enters the portal circulation and is oxidized by the hepatic enzyme into trimethylamine oxide (TMAO). Increased TMAO levels have been reported in elderly people. High TMAO levels are linked to peripheral artery disease (PAD), endothelial senescence, and vascular aging. Emerging evidence showed the beneficial role of probiotics and prebiotics in the management of several atherogenic risk factors through the remodeling of the gut microbiota, thus leading to a reduction in TMAO levels and atherosclerotic lesions. Despite the promising outcomes in different studies, the definite mechanisms of gut dysbiosis and microbiota-derived TMAO involved in atherosclerosis remain not fully understood. More studies are still required to focus on the molecular mechanisms and precise treatments targeting gut microbiota and leading to atheroprotective effects.
Hepatic Energy Metabolism under the Local Control of the Thyroid Hormone System
Creators: name: Seifert, Joshua
name: Chen, Yingfu
name: Schöning, Wenzel
name: Mai, Knut
name: Tacke, Frank
name: Spranger, Joachim
name: Köhrle, Josef
name: Wirth, Eva Katrin
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2023
Subjects: subject: T3
subject: T4
subject: NAFLD
subject: energy metabolism
subject: deiodinase
subject: cholesterol
subject: lipid metabolism
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: The energy homeostasis of the organism is orchestrated by a complex interplay of energy substrate shuttling, breakdown, storage, and distribution. Many of these processes are interconnected via the liver. Thyroid hormones (TH) are well known to provide signals for the regulation of energy homeostasis through direct gene regulation via their nuclear receptors acting as transcription factors. In this comprehensive review, we summarize the effects of nutritional intervention like fasting and diets on the TH system. In parallel, we detail direct effects of TH in liver metabolic pathways with regards to glucose, lipid, and cholesterol metabolism. This overview on hepatic effects of TH provides the basis for understanding the complex regulatory network and its translational potential with regards to currently discussed treatment options of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) involving TH mimetics.
Anomalous Electronic Structure and Pseudogap Effects in Nd1.85Ce0.15CuO4
Creators: name: Armitage, N. P.
name: Damascelli, A.
name: Kim, C.
name: Lu, D. H.
name: Shen, K. M.
Publisher: name: The American Physical Society
Year: 2001
Subjects: subject: 530

description: Physical Review Letters
Glucose-Induced Hemodynamic and Metabolic Response of Skeletal Muscle in Heart Failure Patients with Reduced vs. Preserved Ejection Fraction—A Pilot Study
Creators: name: Boschmann, Michael
name: Klug, Lars
name: Edelmann, Frank
name: Sandek, Anja
name: Haehling, Stephan Von
name: Düngen, Hans-Dirk
name: Springer, Jochen
name: Anker, Stefan D.
name: Doehner, Wolfram
name: Jauert, Nadja
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: insulin resistance
subject: skeletal muscle
subject: metabolism
subject: microdialysis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: (1) Background: Insulin resistance (IR) is a characteristic pathophysiologic feature in heart failure (HF). We tested the hypothesis that skeletal muscle metabolism is differently impaired in patients with reduced (HFrEF) vs. preserved (HFpEF) ejection fraction. (2) Methods: carbohydrate and lipid metabolism was studied in situ by intramuscular microdialysis in patients with HFrEF (59 +/- 14y, NYHA I-III) and HFpEF (65 +/- 10y, NYHA I-II) vs. healthy subjects of similar age during the oral glucose load (oGL); (3) Results: There were no difference in fasting serum and interstitial parameters between the groups. Blood and dialysate glucose increased significantly in HFpEF vs. HFrEF and controls upon oGT (both p < 0.0001), while insulin increased significantly in HFrEF vs. HFpEF and controls (p < 0.0005). Muscle tissue perfusion tended to be lower in HFrEF vs. HFpEF and controls after the oGL (p = 0.057). There were no differences in postprandial increases in dialysate lactate and pyruvate. Postprandial dialysate glycerol was higher in HFpEF vs. HFrEF and controls upon oGL (p = 0.0016); (4) Conclusion: A pattern of muscle glucose metabolism is distinctly different in patients with HFrEF vs. HFpEF. While postprandial IR was characterized by impaired tissue perfusion and higher compensatory insulin secretion in HFrEF, reduced muscle glucose uptake and a blunted antilipolytic effect of insulin were found in HFpEF.
Gezielte Therapien der Psoriasis
Creators: name: Kokolakis, Georgios
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2023
Subjects: subject: Psoriasis
subject: Therapy
subject: Biologics
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Psoriasis ist eine chronisch-entzündliche Erkrankung, die außer der Haut und den Nägeln auch die Enthesen und die Gelenke betreffen kann. Durch die Fortschritte im Verständnis der Immunpathogenese der Psoriasis wurden neue hochwirksame gezielte Therapien entwickelt. Diese neuen Therapien ermöglichen individuelle Therapiekonzepte für die Betroffenen. Solche personalisierten Therapien garantieren die höchste Wirksamkeit mit den geringsten Nebenwirkungen. Die TNFα-Inhibitoren sind die ersten gezielten Therapien für Psoriasis. Darüber hinaus bietet die Entwicklung von Antikörpern gegenüber IL-12/IL-23, IL-17 und IL-23 mehr Therapiemöglichkeiten für Psoriasis. In dieser Arbeit wurde die Anwendung von den verschiedenen Klassen von Biologika (Adalimumab, Brodalumab und Ustekinumab) bei Psoriasispatienten:innen in besonderen Situationen untersucht. Das Ziel dieser Arbeit war die Unterstützung der Therapieentscheidung bei Psoriasispatienten:innen basierend auf einem klinischen Profiling.
title: Popularisierung von Wissenschaft in der Wissensgesellschaft
title: eine Exploration von Theorien und Dokumenten
titleType: AlternativeTitle
Creators: name: Eichholz, Daniela
Publisher: name: Technische Universität Dortmund
Year: 2010
Subjects: subject: Soziologie
subject: Wissenschaftssoziologie
subject: Wissenssoziologie
subject: Wissensgesellschaft
subject: Popularisierung
subject: Wissenschaftskommunikation
subject: Science communication
subject: Science Centers
subject: Wissenschaftsjournalismus
subject: Science Events
subject: Public Understanding of Science (PUS)
subject: Öffentlichkeit
subject: Scientific citizen
subject: Scientific literacy
subject: Nichtwissen
subject: Risiko
subject: Technikfolgenabschätzung
subject: Konsensuskonferenzen
subject: 300

description: Das zentrale Forschungsanliegen, das der Dissertation zugrunde liegt, besteht in einer Analyse potentieller Relationen zwischen der augenfälligen Prominenz des Begriffs der Wissensgesellschaft (einerseits) und der im vergangenen Jahrzehnt beobachtbaren Zunahme von ‚öffentlichkeitswirksamen‘ Formaten der Wissenschaftspopularisierung (andererseits). Im ersten Teil der Arbeit werden Theorien der Wissensgesellschaft sowie die politische und die sozialwissenschaftliche Debatte um diese Zeitdiagnose vorgestellt. Aus einer vergleichenden Gegenüberstellung unterschiedlicher kursierender Begriffsverständnisse wird eine systematisierende Typologie ursprünglicher und aktueller Charakterisierungen von Wissensgesellschaften – einschließlich artverwandter gesellschaftlicher Szenarien – abgeleitet. Im zweiten Teil der Arbeit werden Praxisfelder der Wissenschaftspopularisierung und ihre jeweils typischen Praxisprobleme skizziert. Daran anschließend werden die Verwendungsweisen des Begriffs ‚Wissensgesellschaft‘ in den Praxisfeldern ‚Popularisierungsinitiativen‘, ‚Wissenschaftsjournalismus‘ und ‚Science Centers‘ (mithilfe der dramatologischen Perspektive) daraufhin interpretiert, inwiefern der Begriff ‚Wissensgesellschaft‘ zur Legitimation der Wissenschaftspopularisierung eingesetzt wird und ob anhand der Thematisierung von Wissensgesellschaft in den genannten Praxisbereichen die (Mit-)Konstruktion einer Wissensgesellschaft erkennbar wird. Unter Einbezug verschiedener Öffentlichkeitstheorien werden die Fragen nach zukünftigen Entwicklungstrends in diversen Praxisbereichen der Wissenschaftspopularisierung bearbeitet sowie die Möglichkeit der Konstruktion einer Wissensgesellschaft erörtert.
Fiction and empire : contemporary Australian fiction which recreates the settlement of Australia reflects the relationship between culture and empire
Creators: name: Watkins, Catherine.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Enhanced Apoptosis and Loss of Cell Viability in Melanoma Cells by Combined Inhibition of ERK and Mcl-1 Is Related to Loss of Mitochondrial Membrane Potential, Caspase Activation and Upregulation of Proapoptotic Bcl-2 Proteins
Creators: name: Peng, Zhe
name: Gillissen, Bernhard
name: Richter, Antje
name: Sinnberg, Tobias
name: Schlaak, Max S.
name: Eberle, Jürgen
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2023
Subjects: subject: melanoma
subject: apoptosis
subject: Bcl-2 proteins
subject: Mcl-1
subject: Bim
subject: Puma
subject: Noxa
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Targeting of MAP kinase pathways by BRAF inhibitors has evolved as a key therapy for BRAF-mutated melanoma. However, it cannot be applied for BRAF-WT melanoma, and also, in BRAF-mutated melanoma, tumor relapse often follows after an initial phase of tumor regression. Inhibition of MAP kinase pathways downstream at ERK1/2, or inhibitors of antiapoptotic Bcl-2 proteins, such as Mcl-1, may serve as alternative strategies. As shown here, the BRAF inhibitor vemurafenib and the ERK inhibitor SCH772984 showed only limited efficacy in melanoma cell lines, when applied alone. However, in combination with the Mcl-1 inhibitor S63845, the effects of vemurafenib were strongly enhanced in BRAF-mutated cell lines, and the effects of SCH772984 were enhanced in both BRAF-mutated and BRAF-WT cells. This resulted in up to 90% loss of cell viability and cell proliferation, as well as in induction of apoptosis in up to 60% of cells. The combination of SCH772984/S63845 resulted in caspase activation, processing of poly (ADP-ribose) polymerase (PARP), phosphorylation of histone H2AX, loss of mitochondrial membrane potential, and cytochrome c release. Proving the critical role of caspases, a pan-caspase inhibitor suppressed apoptosis induction, as well as loss of cell viability. As concerning Bcl-2 family proteins, SCH772984 enhanced expression of the proapoptotic Bim and Puma, as well as decreased phosphorylation of Bad. The combination finally resulted in downregulation of antiapoptotic Bcl-2 and enhanced expression of the proapoptotic Noxa. In conclusion, combined inhibition of ERK and Mcl-1 revealed an impressive efficacy both in BRAF-mutated and WT melanoma cells, and may thus represent a new strategy for overcoming drug resistance.
The Immune Checkpoint Landscape in Tumor Cells of Pancreatic Ductal Adenocarcinoma
Creators: name: Loch, Florian N.
name: Kamphues, Carsten
name: Beyer, Katharina
name: Schineis, Christian
name: Rayya, Wael
name: Lauscher, Johannes C.
name: Horst, David
name: Dragomir, Mihnea P.
name: Schallenberg, Simon
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2023
Subjects: subject: pancreatic ductal adenocarcinoma
subject: immune checkpoints
subject: survival
subject: immune checkpoint inhibitors
subject: immune checkpoint treatment
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Immune checkpoint therapy (ICT) has shown promising potential in the treatment of multiple solid tumors. However, the role of ICT in pancreatic ductal adenocarcinoma (PDAC) remains limited. Patterns of immune checkpoints (ICs) in PDAC represent the basis for establishing a potent ICT. The aim of this study is to create a profile of IC expression and its prognostic relevance in cancer cells of PDAC. Therefore, tumor cells from peripheral and central tissue microarray (TMA) spots from histologically confirmed PDAC of 68 patients after tumor resection were investigated in terms of expressions of TIM3, IDO, B7H4, LAG3, VISTA, and PD-L1 using immunohistochemistry. The presence of the respective ICs was compared to overall survival (OS). The presence of VISTA and PD-L1 significantly correlates with shorter OS (median OS: 22 months vs. 7 months and 22 months vs. 11 months, respectively, p < 0.05). For the presence of TIM3, IDO, B7H4, and LAG3, no difference in OS was observed (p > 0.05). The analysis of OS of combined subgroups for VISTA and PD-L1 (VISTA and PD-L1 neg., VISTA pos. and PD-L1 neg., VISTA neg. and PD-L1 pos., and VISTA and PD-L1 pos.) yielded overall statistical significance difference (p = 0.02). These results suggest that the presence of VISTA and PD-L1 is of prognostic relevance and potentially qualifies them as targets for ICT.
Serum CXCL5 Detects Early Hepatocellular Carcinoma and Indicates Tumor Progression
Creators: name: Laschtowitz, Alena
name: Lambrecht, Joeri
name: Puengel, Tobias
name: Tacke, Frank
name: Mohr, Raphael
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2023
Subjects: subject: hepatocellular carcinoma (HCC)
subject: chemokines
subject: biomarker
subject: cirrhosis
subject: etiology
subject: C-X-C motif chemokine ligand (CXCL) 5
subject: CXCL9
subject: CXCL10
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Chemokines or chemotactic cytokines play a pivotal role in the immune pathogenesis of liver cirrhosis and hepatocellular carcinoma (HCC). Nevertheless, comprehensive cytokine profiling data across different etiologies of liver diseases are lacking. Chemokines might serve as diagnostic and prognostic biomarkers. In our study, we analyzed serum concentrations of 12 inflammation-related chemokines in a cohort of patients (n = 222) with cirrhosis of different etiologies and/or HCC. We compared 97 patients with cirrhosis and treatment-naive HCC to the chemokine profile of 125 patients with cirrhosis but confirmed absence of HCC. Nine out of twelve chemokines were significantly elevated in sera of cirrhotic patients with HCC compared to HCC-free cirrhosis controls (CCL2, CCL11, CCL17, CCL20, CXCL1, CXCL5, CXCL9, CXCL10, CXCL11). Among those, CXCL5, CXCL9, CXCL10, and CXCL11 were significantly elevated in patients with early HCC according to the Barcelona Clinic Liver Cancer (BCLC) stages 0/A compared to cirrhotic controls without HCC. In patients with HCC, CXCL5 serum levels were associated with tumor progression, and levels of CCL20 and CXCL8 with macrovascular invasion. Importantly, our study identified CXCL5, CXCL9, and CXCL10 as universal HCC markers, independent from underlying etiology of cirrhosis. In conclusion, regardless of the underlying liver disease, patients with cirrhosis share an HCC-specific chemokine profile. CXCL5 may serve as a diagnostic biomarker in cirrhotic patients for early HCC detection as well as for tumor progression.
Q2-evolution of parton densities at small x values. Charm contribution in the combined H1 and ZEUS F2 data
Creators: name: Kotikov, A. V.
name: Shaikhatdenov, B. G.
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The Bessel-inspired behavior of parton densities at small x, obtained in the case of the flat initial conditions for DGLAP evolution equations, is used in the fixed flavor scheme to analyze precise H1+ZEUS combined data on the structure function F2.
description: 4 pages, 1 figure, talk given at the International Session-Conference SNP PSD RAS "Physics of Fundamental Interactions", April 12 - 15, 2016
Towards a new Russian identity : the rhetoric of Znamia, January-June 1995
Creators: name: Wymond, Margaret Anne.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Moderation & Regeln für ein Doktorandenkolloquium
Creators: name: Metz-Göckel, Sigrid
Publisher: name: Hochschuldidaktisches Zentrum der Technischen Universität Dortmund
Year: 2001
Subjects: subject: 370

description: Doktorandenkolloquien sind Forschungswerkstätten, wobei die Betonung auf Werkstätten liegt. Ihr Anliegen sollte es sein, die Freude am Promovieren mit der Leistungsmotivation so zu verbinden, dass positive Bestärkungen im Vordergrund stehen. Aufgrund langjähriger Erfahrungen mit einem Graduiertenkolleg und mehr als 20 Jahre Durchführung eines Doktorandenkolloquiums hat sich ein Erfahrungsschatz herausgebildet, der im folgenden kurz skizziert und zur kritischen Weiterentwicklung empfohlen wird. Ziel eines Doktorandenkolloqiums ist es, das Eremitendasein der Promovierenden zu verhindern und einen effizienten Austausch mit anderen DoktorandInnen und dem Hochschullehrer oder der Hochschullehrerin so zu gestalten, dass möglichst alle aktiv beteiligt sind. Im folgenden werden einige Regeln vorgestellt, die dies begünstigen.
description: Journal Hochschuldidaktik ; 12. Jahrgang 2001 Heft 2
Erfahrungsbericht über eine ungewöhnliche hochschuldidaktische Kooperation Tutorenqualifizierung in der Fakultät Informatik
Creators: name: Selent, Petra
Publisher: name: Hochschuldidaktisches Zentrum der Technischen Universität Dortmund
Year: 2008
Subjects: subject: 370

description: Journal Hochschuldidaktik ; 19. Jahrgang 2008 Heft 2
The built-up environment modulates the association of artificial night-time lights with the urban extent
Creators: name: Rybnikova, Nataliya
name: Rybnikov, Sviatoslav
name: Broitman, Dani
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
classificationCode: 59999
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
subject: Science Policy
classificationCode: 111714
subject: Mental Health

description: Artificial night-time light (NTL) emissions, collected by satellites, are a reliable and widely used remote proxy for urban extent. Recently, it was demonstrated that NTLs are stronger associated with the total volume of the buildings than with their total footprint area, a traditional urban extent measure. However, this finding may not be a general rule: We presume that both associations are sensitive to characteristics of the built-up environment, while the latter is known to be quite heterogeneous within and between cities. Moreover, we hypothesize that at least in specific built-up environments, NTL may even stronger correlate with another urban extent measure – the total lateral surface area of the buildings, due to its more accurate proportionality to the area of light-emitting windows. The present study uses NTLs and buildings datasets of 38 European capital cities and compares the associations of NTLs with the three aforementioned urban extent measures (the total footprint area, the total volume, and the total lateral surface area of the buildings) across different built-up environments. The results indicate that in urban areas characterized by a high density of tall buildings the strongest observed association is between NTLs and the building’s footprint area. In comparison, the total volume of buildings is better related to NTLs in urban areas that host compact settings of relatively small buildings. But there is a third type of physical urban configuration, characterized by large buildings sparsely distributed in space. In this type of urban area, the strongest observed association is between NTLs and lateral surface area. We conclude that monitoring urban growth using NTLs will benefit from a preliminary assessment of the local built-up characteristics.
Disintegration of the NuRD Complex in Primary Human Muscle Stem Cells in Critical Illness Myopathy
Creators: name: Schneider, Joanna
name: Sundaravinayagam, Devakumar
name: Blume, Alexander
name: Marg, Andreas
name: Grunwald, Stefanie
name: Metzler, Eric
name: Escobar, Helena
name: Müthel, Stefanie
name: Wang, Haicui
name: Wollersheim, Tobias
name: Weber-Carstens, Steffen
name: Akalin, Altuna
name: Di Virgilio, Michela
name: Tursun, Baris
name: Spuler, Simone
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2023
Subjects: subject: epigenetic
subject: muscle stem cell
subject: critical illness
subject: histone 1
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Critical illness myopathy (CIM) is an acquired, devastating, multifactorial muscle-wasting disease with incomplete recovery. The impact on hospital costs and permanent loss of quality of life is enormous. Incomplete recovery might imply that the function of muscle stem cells (MuSC) is impaired. We tested whether epigenetic alterations could be in part responsible. We characterized human muscle stem cells (MuSC) isolated from early CIM and analyzed epigenetic alterations (CIM n = 15, controls n = 21) by RNA-Seq, immunofluorescence, analysis of DNA repair, and ATAC-Seq. CIM-MuSC were transplanted into immunodeficient NOG mice to assess their regenerative potential. CIM-MuSC exhibited significant growth deficits, reduced ability to differentiate into myotubes, and impaired DNA repair. The chromatin structure was damaged, as characterized by alterations in mRNA of histone 1, depletion or dislocation of core proteins of nucleosome remodeling and deacetylase complex, and loosening of multiple nucleosome-spanning sites. Functionally, CIM-MuSC had a defect in building new muscle fibers. Further, MuSC obtained from the electrically stimulated muscle of CIM patients was very similar to control MuSC, indicating the impact of muscle contraction in the onset of CIM. CIM not only affects working skeletal muscle but has a lasting and severe epigenetic impact on MuSC.