cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Risk factors for Drug-Related Non-Infectious pneumonia: insights from the FDA adverse event reporting system (FAERS)
Creators: name: Meng, Peize
name: Zhang, Yi
name: Zhao, Qingnan
name: Zhang, Hang
name: Ruan, Zheng
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Mental Health

description: Non-infectious pneumonitis (NIP) is a severe adverse drug reaction. To better understand drug-induced NIP, improve patient safety, and inform clinical decision-making, this study aims to utilize the FDA Adverse Event Reporting System (FAERS) database to evaluate the association between medications and NIP, identify potential risk factors, and offer clinical alerts. We reviewed the FAERS database from the 2004 through the second quarter of 2024. Using ‘NIP’ as the search term, we sorted, counted, and analyzed cases by generic drug name and trends of reports related to NIP submitted to FAERS database. We employed four statistical methods to identify drugs associated with the NIP. From 21,433,114 reported drug adverse events (AEs), 9,224 cases were classified as NIP. Our analysis identified 20 drugs associated with NIP, with the main categories being antineoplastic agents, antibiotics and immunosuppressants. Daptomycin, methotrexate, and tacrolimus had the highest NIP-related deaths. Trends in AEs reporting indicate that the drugs showing the fastest increase in NIP reports are daptomycin, methotrexate, sertraline, and amiodarone. These findings could assist clinicians in the early identification of drug-related NIP and provide valuable insights for future research into the mechanisms underlying drug-related NIP.
sj-pdf-1-taj-10.1177_20406223211028768 – Supplemental material for Blood eosinophil count-guided corticosteroid therapy and as a prognostic biomarker of exacerbations of chronic obstructive pulmonary disease: a systematic review and meta-analysis
Creators: name: Liu, Tao
name: Xiang, Zi-Jian
name: Hou, Xiao-Meng
name: Chai, Jing-Jing
name: Yang, Yan-Li
name: Zhang, Xiao-Tong
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Cardiology
subject: Endocrinology
subject: Geriatrics and Gerontology
subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Aged Health Care
subject: Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: Psychology not elsewhere classified
subject: Psychiatry (incl. Psychotherapy)
subject: Respiratory Diseases

description: Supplemental material, sj-pdf-1-taj-10.1177_20406223211028768 for Blood eosinophil count-guided corticosteroid therapy and as a prognostic biomarker of exacerbations of chronic obstructive pulmonary disease: a systematic review and meta-analysis by Tao Liu, Zi-Jian Xiang, Xiao-Meng Hou, Jing-Jing Chai, Yan-Li Yang and Xiao-Tong Zhang in Therapeutic Advances in Chronic Disease
Knockdown of porcine endogenous retrovirus (PERV) expression by PERV-specific shRNA in transgenic pigs
Creators: name: Dieckhoff, Britta
name: Petersen, Björn
name: Kues, Wilfried A.
name: Kurth, Reinhard
name: Niemann, Heiner
name: Denner, Joachim
Publisher: name: Robert Koch-Institut
Year: 2008
Subjects: subject: Animals
subject: Humans
subject: Cells
subject: Cultured
subject: RNA
subject: Swine
subject: Genetically Modified
subject: Fibroblasts/cytology
subject: Fibroblasts/physiology
subject: Small Interfering/genetics
subject: Small Interfering/metabolism
subject: Retroviridae*/genetics
subject: Retroviridae*/metabolism
subject: Transplantation
subject: Heterologous
subject: 610 Medizin

description: Background: Xenotransplantation using porcine cells, tissues or organs may be associated with the transmission of porcine endogenous retroviruses (PERVs). More than 50 viral copies have been identified in the pig genome and three different subtypes of PERV were released from pig cells, two of them were able to infect human cells in vitro. RNA interference is a promising option to inhibit PERV transmission. Methods: We recently selected an efficient si (small interfering) RNA corresponding to a highly conserved region in the PERV DNA, which is able to inhibit expression of all PERV subtypes in PERV-infected human cells as well as in primary pig cells. Pig fibroblasts were transfected using a lentiviral vector expressing a corresponding sh (short hairpin) RNA and transgenic pigs were produced by somatic nuclear transfer cloning. Integration of the vector was proven by PCR, expression of shRNA and PERV was studied by in-solution hybridization analysis and real-time RT PCR, respectively. Results: All seven born piglets had integrated the transgene. Expression of the shRNA was found in all tissues investigated and PERV expression was significantly inhibited when compared with wild-type control animals. Conclusion: This strategy may lead to animals compatible with PERV safe xenotransplantation.
Potentially inappropriate anticholinergic drug use among older adults in primary healthcare: prevalence and determinants
Creators: name: Rodrigues, Daniela A.
name: Herdeiro, Maria Teresa
name: Mateos-Campos, Ramona
name: Figueiras, Adolfo
name: Roque, Fátima
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Considering the vulnerability of older adults to adverse drug reactions, medications with strong anticholinergic properties are considered potentially inappropriate for this population. This study aims to characterize older adults’ profile of anticholinergics use and to identify the factors associated with their potentially inappropriate use. A retrospective study was conducted on 1200 older adults in primary health care centers of Portugal between April 2021 and August 2022. Potentially inappropriate use was assessed according to the 2023 Beers criteria. Logistic regression analyses were performed to determine associations between independent variables and potentially inappropriate use. A 8.9% (95% CI 0.074–0.107) of the older adults were exposed to one or more potentially inappropriate anticholinergics, and amitriptyline was the most used (2.0%). Multivariate analysis revealed that use was associated with a higher mean number of medications (OR 1.173, 95% CI 1.115–1.234), diagnoses of depression (OR 2.889, 95% CI 1.785–4.674) and psychiatric disorders (OR 1.654, 95% CI 1.003–2.729). This study underscores the importance of vigilance in prescribing anticholinergic medications to older adults, particularly those with higher medication burdens and mental health diagnoses. By identifying factors associated with potentially inappropriate use, healthcare providers can better tailor medication regimens to mitigate risks and optimize the well-being of older adults.
Additional file 1 of An equine iPSC-based phenotypic screening platform identifies pro- and anti-viral molecules against West Nile virus
Creators: name: Cochet, Marielle
name: Piumi, François
name: Gorna, Kamila
name: Berry, Noémie
name: Gonzalez, Gaëlle
name: Danckaert, Anne
name: Aulner, Nathalie
name: Blanchet, Odile
name: Zientara, Stéphan
name: Donadeu, Francesc Xavier
name: Munier-Lehmann, Hélène
name: Richardson, Jennifer
name: Benchoua, Alexandra
name: Coulpier, Muriel
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 1. List of 41 selected compounds tested for their antiviral activity in WNV-infected eNPCs.
Prioritisation of infectious diseases in public health - call for comments
Creators: name: Krause, Gérard
Publisher: name: Robert Koch-Institut
Year: 2008
Subjects: subject: Communicable Diseases/classification
subject: Humans
subject: Germany
subject: Public Health
subject: Population Surveillance
subject: Europe
subject: Feedback
subject: Resource Allocation/organization & administration
subject: 610 Medizin

description: In order to allocate rationally resources for research and surveillance of infectious diseases at the level of the German public health institute (RKI), we prioritised pathogens by public health criteria. After screening the relevant literature we developed a standardised methodology including a three-tiered scoring system for selected pathogens. The pathogens were rated in four categories containing a total of 12 criteria: burden of disease including incidence, severity, mortality; epidemiologic dynamic including outbreak potential, trend, emerging potential; information need including evidence on risk factors/groups, validity of epidemiologic information, evidence for pathogenesis; international duties and public attention; health gain opportunity including preventability, treatability. For each criterion a numerical score of +1, 0 or -1 was given and each criterion received a weight by which the numerical score of each criterion was to be multiplied. The total weighted scores ranged from +22.7 (influenza) to - 64.4 (cholera) with the median being -22.9 (rubella). Relevant changes were observed between weighted and unweighted scores. The chosen approach proved to be feasible and the result plausible. However, in order to further improve the methodology we invite experts to give feedback on the methodology via a structured web-based questionnaire at www.rki.de/EN > Prevention of infection > Infectious Disease Surveillance > Pathogen prioritization. Results of this survey will be included in a modification of the methodology.
IDENTIFICATION OF FIRMS CAPABLE OF PRODUCING RENEWABLE ENERGY COMPONENTS IN THE KENTUCKY BLUGRASS REGION: A COMPARISON OF REPP STANDARDS CLASSIFICATION USAGE VERSUS SELF-IDENTIFICATION USING ONLINE SURVEYS
Creators: name: Abney, Scott A
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Logistics
Supply chains

description: While the energy field has been primarily dominated by fossil fuels such as coal and oil, there is evidence that renewable energy sources are starting to gain a stronger foothold in the energy market to accommodate growth (Debbage, 2008; Intelligent, 2008; Sterzinger, 2006). This has been the result of greater social concern, as well as tax and other government incentives (Intelligent, 2008; Debbage, 2008). Due to these trends, a growing market opportunity exists for cities and states to increase their renewable energy component production (Intelligent, 2008; Regional, 2013; Debbage, 2008; IPCC, 2014). The primary purpose of this study was to survey existing manufacturers in the Bluegrass Region of Kentucky to obtain information and identify manufacturers who: were currently in the renewable energy market, interested in entering the renewable energy market, or have no interest in entering the renewable energy market. Respondents also addressed potential barriers to the growth of the renewable energy field including workforce development, government policy, and investment capital. A total of 25 companies responded to the survey. Correlation analysis was used and determined that no significant correlation existed between surveyed companies who identified themselves as suppliers of renewable energy components and those companies who were identified as possible suppliers of renewable energy components within the REPP (Renewable Energy Policy Project) standards. This study builds on previous methodology used by Debbage (2008) for North Carolina.
sj-pdf-1-ijb-10.1177_13670069211023144 – Supplemental material for Towards a coherent methodology for the documentation of small-scale multilingualism: Dealing with speech data
Creators: name: Di Carlo, Pierpaolo
name: Ojong Diba, Rachel A.
name: Good, Jeff
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Education
subject: 200399 Language Studies not elsewhere classified
subject: FOS: Languages and literature
subject: Sociology
subject: FOS: Sociology

description: Supplemental material, sj-pdf-1-ijb-10.1177_13670069211023144 for Towards a coherent methodology for the documentation of small-scale multilingualism: Dealing with speech data by Pierpaolo Di Carlo, Rachel A. Ojong Diba and Jeff Good in International Journal of Bilingualism
Non-Gaussian Interference in High Frequency, Underwater Acoustic, and Molecular Communication
Creators: name: Lo, Hung-Yi
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Electrical engineering not elsewhere classified

description: The implications of non-Gaussian interference for various communication systemsare explored. The focus is on the Kappa distribution, Generalized Gaussian distribu-tions, and the distribution of the interference in molecular communication systems.A review of how dynamic systems that are not in equilibrium are modeled by theKappa distribution and how this distribution models interference in HF communica-tions systems at sunrise is provided. The channel model, bit error rate for single andmultiple antennas, channel capacity, and polar code performance are shown.
Next, a review of the Generalized Gaussian distribution that has been found tomodel the interference resulting from surface activities is provided. This modeling isextended to find the secrecy capacity so that information cannot be obtained by theeavesdropper.
Finally, future nanomachnines are examined. The vulnerability to a receptorantagonist of a ligand-based molecule receiver is explored. These effects are consideredto be interference as in other wireless systems and the damage to signal reception isquantified.
Control of Flagellar Gene Regulation in Legionella pneumophila and Its Relation to Growth Phase
Creators: name: Albert-Weissenberger, Christiane
name: Sahr, Tobias
name: Sismeiro, Odile
name: Hacker, Jörg
name: Heuner, Klaus
name: Buchrieser, Carmen
Publisher: name: Robert Koch-Institut
Year: 2009
Subjects: subject: Animals
subject: Western
subject: Cell Line
subject: Flagellin/genetics
subject: Flagellin/metabolism
subject: Gene Expression Regulation
subject: Polymerase Chain Reaction
subject: Mice
subject: Microscopy
subject: Mutation
subject: Bacterial Proteins/genetics
subject: Electron
subject: Blotting
subject: Bacterial Proteins/physiology
subject: Cyclic GMP/analogs & derivatives
subject: Cyclic GMP/metabolism
subject: Cyclic GMP/physiology
subject: Flagella/genetics
subject: Flagella/physiology
subject: Flagella/ultrastructure
subject: Bacterial*/genetics
subject: Bacterial*/physiology
subject: Legionella pneumophila/genetics
subject: Legionella pneumophila/growth & development
subject: Legionella pneumophila/metabolism
subject: Legionella pneumophila/ultrastructure
subject: Transmission
subject: Oligonucleotide Array Sequence Analysis
subject: 610 Medizin

description: The bacterial pathogen Legionella pneumophila responds to environmental changes by differentiation. At least two forms are well described: replicative bacteria are avirulent; in contrast, transmissive bacteria express virulence traits and flagella. Phenotypic analysis, Western blotting, and electron microscopy of mutants of the regulatory genes encoding RpoN, FleQ, FleR, and FliA demonstrated that flagellin expression is strongly repressed and that the mutants are nonflagellated in the transmissive phase. Transcriptome analyses elucidated that RpoN, together with FleQ, enhances transcription of 14 out of 31 flagellar class II genes, which code for the basal body, hook, and regulatory proteins. Unexpectedly, FleQ independent of RpoN enhances the transcription of fliA encoding sigma 28. Expression analysis of a fliA mutant showed that FliA activates three out of the five remaining flagellar class III genes and the flagellar class IV genes. Surprisingly, FleR does not induce but inhibits expression of at least 14 flagellar class III genes on the transcriptional level. Thus, we propose that flagellar class II genes are controlled by FleQ and RpoN, whereas the transcription of the class III gene fliA is controlled in a FleQ-dependent but RpoN-independent manner. However, RpoN and FleR might influence flagellin synthesis on a posttranscriptional level. In contrast to the commonly accepted view that enhancer-binding proteins such as FleQ always interact with RpoN to fullfill their regulatory functions, our results strongly indicate that FleQ regulates gene expression that is RpoN dependent and RpoN independent. Finally, FliA induces expression of flagellar class III and IV genes leading to the complete synthesis of the flagellum.
Quantification of longitudinal patient-reported burden of adverse drug reactions attributed to the use of TNF-α inhibitors in inflammatory rheumatic diseases: an observational prospective cohort study
Creators: name: König, Benthe H.
name: Gosselt, Helen R.
name: van Lint, Jette A.
name: Kosse, Leanne J.
name: van den Bemt, Bart J. F.
name: Klooster, Peter M. ten
name: Vonkeman, Harald E.
name: Jessurun, Naomi T.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: There is a lack of knowledge on patient perspectives on adverse drug reactions (ADRs) attributed to the use of biologics. The aim of this study is to quantify the burden over time of ADRs attributed to TNF-α inhibitors in patients with inflammatory rheumatic diseases (IRDs) and investigate whether the burden over time differs between different types of ADRs. Data were used from the Dutch Biologic Monitor (DBM), an observational prospective cohort study for patient-reported ADRs attributed to biologics. Patients with an IRD using a TNF-α inhibitor reporting an ADR, lasting for three consecutive questionnaires, were included. Questionnaires were sent every 2 months and the burden was scored on a 5-point Likert-type scale. Burden scores were analyzed using linear mixed models. Data from 166 unique patients reporting 274 ADRs were included. The burden score decreased every month by 0.29 points (95% CI −0.34 – −0.24) on average on a 5-point Likert-type scale. The burden score for infections and infestations decreased significantly faster than the burden score for injection site reactions. Patient-reported burden of ADRs attributed to the use of a TNF-α inhibitor in patients with IRDs decreased significantly over time, especially for infections and infestations.
Los continentes y las poblaciones de nuestros sueños: La niñez en "Mala letra", de Sara Mesa
Creators: name: Díaz-Navarro, Epicteto
Publisher: name: iberoamericana Vervuert
Year: 2019
Subjects: subject: Spanish literature
subject: Short stories

description: Sara Mesa's narratives show us that a good part of our assumptions about childhood, about innocence and new experiences, do not correspond to that stage that cannot be understood in terms of adult life. They place us before the unspeakable, before the limitations of our thinking of an enigmatic other that seemed easy to understand.
sj-pdf-1-spo-10.1177_17479541211031170 - Supplemental material for Can discreet performance banding, as compared to bio-banding, discriminate technical skills in male adolescent soccer players? A preliminary investigation
Creators: name: Moran, Jason
name: Cervera, Victor
name: Jones, Benjamin
name: Hope, Edward
name: Drury, Ben
name: Sandercock, Gavin
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Sociology
subject: FOS: Sociology

description: Supplemental material, sj-pdf-1-spo-10.1177_17479541211031170 for Can discreet performance banding, as compared to bio-banding, discriminate technical skills in male adolescent soccer players? A preliminary investigation by Jason Moran, Victor Cervera, Benjamin Jones, Edward Hope, Ben Drury and Gavin Sandercock in International Journal of Sports Science & Coaching
sj-pdf-1-erp-10.1177_08902070211028696 - Supplemental material for Examining the Longitudinal Associations Between Repeated Narration of Recent Transgressions Within Individuals’ Romantic Relationships and Character Growth in Empathy, Humility, and Compassion
Creators: name: ER Blackie, Laura
name: Jayawickreme, Eranda
name: Blackie, Laura E. R.
name: McLean, Kate C.
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, sj-pdf-1-erp-10.1177_08902070211028696 for Examining the Longitudinal Associations Between Repeated Narration of Recent Transgressions Within Individuals’ Romantic Relationships and Character Growth in Empathy, Humility, and Compassion by Laura E. R. Blackie and Kate C. McLean in European Journal of Personality
Implementation of Microphone Array Processing Techniques on A Synthetic Array for Fluid Power Noise Diagnostics
Creators: name: Ding, Dan
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Mechanical engineering not elsewhere classified
Acoustics and noise control (excl. architectural acoustics)

description: Fluid power is widely used in a variety of applications such as construction machines, aerospace, automotive, agricultural machinery, manufacturing, etc. Although this technology has many obvious advantages such as compactness, robustness, high power density, and so forth, there is much room for improvement, of which one of the most important and challenging problems is the noise.
Different institutes have been researching fluid power noise for decades. However, much of the experimental investigation was based on simple measurement and analysis techniques, which left the designers/researchers no method of understanding the complicated phenomena. A microphone array is a powerful tool that unfortunately has not been introduced to the fluid power noise research. By capturing the magnitude and phase information in space, a microphone array enables the noise source identification, separation, localization and so forth.
This thesis focuses on implementing the microphone array processing techniques on a synthetic microphone array for fluid power noise diagnostics. Differing from traditional scan-based approaches, the synthetic array is created by synchronizing the non-synchronous measurements to achieve the equivalent effect of a multi-microphone snapshot. The final results will show the power of microphone arrays and provide an economical solution to achieve approximate results when a real microphone array is not available.
A real-world disproportionality analysis of baloxavir marboxil: post-marketing pharmacovigilance data
Creators: name: Zhou, Jie
name: Ye, Junchang
name: Chen, Maohua
name: Zheng, Xinlei
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine

description: Baloxavir marboxil (hereafter referred to as baloxavir) is the only cap-dependent endonuclease inhiabitor approved for the treatment and prevention of influenza. However, as a new drug marketed in 2018, the long-term safety of baloxavir in large sample population was unclear. This study aims to evaluate baloxavir-associated adverse events (AEs) through data mining of the international pharmacovigilance database of US FDA Adverse Event Reporting System (FAERS). Disproportionality analysis was conducted to assess the association between baloxavir and its AEs. Data were collected from FAERS from March 2018 to June 2023. After standardizing the data, signal quantification techniques including ROR, PRR, BCPNN and MGPS were used for analysis. A total of 49 significant baloxavir-related preferred terms (PTs) in 20 system organ classes (SOCs) were identified in our data analysis. Compared to baloxavir’s FDA label, some new PTs emerged, with the top 10 being pneumonia, loss of consciousness, rhabdomyolysis, seizure, altered state of consciousness, hepatic function abnormal, delirium, depressed level of consciousness, encephalopathy and cardio-respiratory arrest. In clinical application of baloxavir, attention should be paid to the new AE signals in addition to the those recorded in the labels, so as to ensure the safety of the patients.
Supplemental Material, sj-pdf-1-jic-10.1177_08850666211024184 - Intensive Care Unit Volume of Sepsis Patients Does Not Affect Mortality: Results of a Nationwide Retrospective Analysis
Creators: name: Naar, Leon
name: Hechi, Majed W. El
name: Gallastegi, Ander Dorken
name: Renne, B. Christian
name: Fawley, Jason
name: Parks, Jonathan J.
name: Mendoza, April E.
name: Saillant, Noelle N.
name: Velmahos, George C.
name: Kaafarani, Haytham M. A.
name: Lee, Jarone
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110305 Emergency Medicine
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 110203 Respiratory Diseases

description: Supplemental Material, sj-pdf-1-jic-10.1177_08850666211024184 for Intensive Care Unit Volume of Sepsis Patients Does Not Affect Mortality: Results of a Nationwide Retrospective Analysis by Leon Naar, Majed W. El Hechi, Ander Dorken Gallastegi, B. Christian Renne, Jason Fawley, Jonathan J. Parks, April E. Mendoza, Noelle N. Saillant, George C. Velmahos, Haytham M. A. Kaafarani and Jarone Lee in Journal of Intensive Care Medicine
A real-world disproportionality analysis of Baloxavir Marboxil: post-marketing pharmacovigilance data
Creators: name: Zhou, Jie
name: Ye, Junchang
name: Chen, Maohua
name: Zheng, Xinlei
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine

description: Baloxavir marboxil (hereafter referred to as baloxavir) is the only cap-dependent endonuclease inhibitor approved for the treatment and prevention of influenza. However, as a new drug marketed in 2018, the long-term safety of baloxavir in large sample population was unclear. This study aims to evaluate baloxavir-associated adverse events (AEs) through data mining of the international pharmacovigilance database of US FDA Adverse Event Reporting System (FAERS). Disproportionality analysis was conducted to assess the association between baloxavir and its AEs. Data were collected from FAERS from March 2018 to June 2023. After standardizing the data, signal quantification techniques including ROR, PRR, BCPNN and MGPS were used for analysis. A total of 49 significant baloxavir-related preferred terms (PTs) in 20 system organ classes (SOCs) were identified in our data analysis. Compared to baloxavir’s FDA label, some new PTs emerged, with the top 10 being pneumonia, loss of consciousness, rhabdomyolysis, seizure, altered state of consciousness, hepatic function abnormal, delirium, depressed level of consciousness, encephalopathy and cardio-respiratory arrest. In clinical application of baloxavir, attention should be paid to the new AE signals in addition to the those recorded in the labels, so as to ensure the safety of the patients.
sj-docx-1-tam-10.1177_17588359211028492 – Supplemental material for Characterization of circulating tumor cells in early breast cancer patients receiving neoadjuvant chemotherapy
Creators: name: Jakabova, Anna
name: Bielcikova, Zuzana
name: Pospisilova, Eliska
name: Petruzelka, Lubos
name: Blasiak, Piotr
name: Bobek, Vladimir
name: Kolostova, Katarina
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 110203 Respiratory Diseases

description: Supplemental material, sj-docx-1-tam-10.1177_17588359211028492 for Characterization of circulating tumor cells in early breast cancer patients receiving neoadjuvant chemotherapy by Anna Jakabova, Zuzana Bielcikova, Eliska Pospisilova, Lubos Petruzelka, Piotr Blasiak, Vladimir Bobek and Katarina Kolostova in Therapeutic Advances in Medical Oncology
Novel cytomegaloviruses in free-ranging and captive great apes: phylogenetic evidence for bidirectional horizontal transmission
Creators: name: Leendertz, Fabian
name: Deckers, Merlin
name: Schempp, Werner
name: Lankester, Felix
name: Boesch, Christophe
name: Mugisha, Lawrence
name: Dolan, Aidan
name: Gatherer, Derek
name: McGeoch, Duncan J.
name: Ehlers, Bernhard
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2009
Subjects: subject: Amino Acid Sequence
subject: Humans
subject: Gene Expression Regulation
subject: Phylogeny
subject: Animals
subject: Base Sequence
subject: Viral Proteins/genetics
subject: Cytomegalovirus/genetics
subject: Cytomegalovirus/isolation & purification
subject: Cytomegalovirus Infections/virology
subject: Ape Diseases/virology
subject: Zoo
subject: Cytomegalovirus/classification
subject: Cytomegalovirus Infections/veterinary
subject: Viral/physiology
subject: Gorilla gorilla/virology
subject: Pan troglodytes/virology
subject: Pongo pygmaeus/virology
subject: Viral Proteins/chemistry
subject: 610 Medizin

description: Wild great apes often suffer from diseases of unknown aetiology. This is among the causes of population declines. Because human cytomegalovirus (HCMV) is an important pathogen, especially in immunocompromised individuals, a search for cytomegaloviruses (CMVs) in deceased wild and captive chimpanzees, gorillas and orang-utans was performed. By using a degenerate PCR targeting four conserved genes (UL54-UL57), several distinct, previously unrecognized CMVs were found for each species. Sequences of up to 9 kb were determined for ten novel CMVs, located in the UL54-UL57 block. A phylogenetic tree was inferred for the ten novel CMVs, the previously characterized chimpanzee CMV, HCMV strains and Old World and New World monkey CMVs. The primate CMVs fell into four clades, containing New World monkey, Old World monkey, orang-utan and human CMVs, respectively, plus two clades that each contained both chimpanzee and gorilla isolates (termed CG1 and CG2). The tree loci of the first four clades mirrored those for their respective hosts in the primate tree, suggesting that these CMV lineages arose through cospeciation with host lineages. The CG1 and CG2 loci corresponded to those of the gorilla and chimpanzee hosts, respectively. This was interpreted as indicating that CG1 and CG2 represented CMV lineages that had arisen cospeciationally with the gorilla and chimpanzee lineages, respectively, with subsequent transfer within each clade between the host genera. Divergence dates were estimated and found to be consistent with overall cospeciational development of major primate CMV lineages. However, CMV transmission between chimpanzees and gorillas in both directions has also occurred.
Additional file 1 of An automatic system for recognizing fly courtship patterns via an image processing method
Creators: name: Chen, Ching-Hsin
name: Lin, Yu-Chiao
name: Wang, Sheng-Hao
name: Kuo, Tsung-Han
name: Tsai, Hung-Yin
Publisher: name: figshare
Year: 2024
Subjects: subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences

description: Additional file 1.Supplementary Information.
Secure Co-design: Confidentiality Preservation in Online Engineering Collaborations
Creators: name: Chaduvula, Siva Chaitanya
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Mechanical engineering not elsewhere classified

description: Research in engineering design assumes that data flows smoothly among different designers within a product realization process. This assumption is not valid in many scenarios, including when designers partner with a future competitor or when designers search for potential collaborators is hampered by an inability to share sensitive data. This information asymmetry among designers has an adverse effect on the outcomes of the product realization process. Designers need a secure yet collaborative design process that enables them to overcome these information-related risks borne from collaborators participating in their product realization process. Existing cryptographic techniques aimed at overcoming these risks are computationally intensive, making them unsuitable for heavy engineering computations such as finite element analysis (FEA). FEA is a widely used computation technique in several engineering applications, including structural analysis, heat transfer, and fluid flow. In this work, we developed a new approach, secure finite element analysis (sFEA), using which designers can perform their analysis without revealing their confidential design data to anyone, including their design collaborators even though the computed answer depends on confidential inputs from all the collaborators. sFEA is a secure, scalable, computationally lightweight, and cloud-compatible. In addition to sFEA, we developed prototypes and demonstrated that the computational framework within sFEA is general enough to be applied to different stages of the product realization process.
Kafka en España: unas notas sobre Carmen Martín Gaite y Enrique Vila-Matas
Creators: name: Díaz-Navarro, Epicteto
Publisher: name: Editorial Complutense
Year: 2013
Subjects: subject: Spanish literature
subject: Comparative literature

description: Franz Kafka is one of the most influential writers in Spanish narrative since the post-war period, from the beginnings of the work of Carmen Martín Gaite, to Enrique Vila-Matas, one of the most widely translated and well-known current novelists.
Evaluation of adding a second marker to overcome Staphylococcus aureus spa-typing homoplasies
Creators: name: Basset, P.
name: Nübel, Ulrich
name: Witte, Wolfgang
name: Blanc, D. S.
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2012
Subjects: subject: Phylogeny
subject: Staphylococcus aureus/genetics
subject: Models Genetic
subject: Staphylococcus aureus/classification
subject: Evolution Molecular
subject: Genetic Markers
subject: Multilocus Sequence Typing
subject: Polymorphism Single Nucleotide
subject: Haplotypes
subject: Adhesins Bacterial/genetics
subject: Antigens Bacterial/genetics
subject: Bayes Theorem
subject: Markov Chains
subject: Monte Carlo Method
subject: 610 Medizin

description: The utility of sequencing a second highly variable locus in addition to the spa gene (e.g., double-locus sequence typing [DLST]) was investigated to overcome limitations of a Staphylococcus aureus single-locus typing method. Although adding a second locus seemed to increase discriminatory power, it was not sufficient to definitively infer evolutionary relationships within a single multilocus sequence type (ST-5).
Drug-associated pancreatic cancer: insights from real-world pharmacovigilance and network pharmacology
Creators: name: Xie, Hao
name: Xu, Qiang
name: Zhao, Bin
name: Wu, Wenming
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Mental Health

description: Pancreatic cancer’s high mortality rate necessitates our study, which aims to identify potential risk drugs and speculate on the underlying mechanisms. All pertinent reports from the FDA Adverse Event Reporting System database were extracted. The disproportionality analysis was used in signal detection and data on patient age, sex, weight, time to onset were collected. Seven databases were retrieved for network pharmacology. AutoDock Vina 1.1.2 was for molecular docking. Signals were detected among 397 drugs with pancreatic cancer report ≥3. Except 4 antineoplastic agents, only 24 drugs indicated pancreatic cancer signals in 33,948 reports including 4 dipeptidyl peptidase-4 (DPP-4) inhibitors, 3 glucagon-like peptide-1 (GLP-1) analogues, 5 compound hypoglycemic agents, 3 hypotensive agents, ranitidine, pancrelipase, fondaparinux, naldemedine, daprodustat, megestrol acetate, leuprorelin, lecanemab, and lorcaserin. Pancreatic cancer more occurred after the age of 45, with a higher proportion among male. Weight with GLP-1 analogues (median, 91 kg), and compound hypoglycemic agents (median, 82 kg) was heavier (p < 0.01). GLP1R (glucagon-like peptide 1 receptor) for GLP-1 analogues, and PTEN (phosphatase and tensin homolog) for metformin might be a potential cause of pancreatic cancer. Clinicians providing these therapies should stay vigilant to detect pancreatic cancer early.
THE INVESTIGATION OF WARM LASER SHOCK PEENING AS A POST PROCESSING TECHNIQUE TO IMPROVE JOINT STRENGTH OF LASER WELDED MATERIALS
Creators: name: Inamke, Gaurav Vilas
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Mechanical engineering not elsewhere classified

description: This study is concerned with investigating the effects of warm laser shock peening (wLSP) on the enhancement of mechanical performance of laser welded joints. A 3-D finite element model is presented which predicts the surface indentation geometry and in-depth compressive residual stresses generated by wLSP. To define the LSP pressure on the surface of the material, a 1-D confined plasma model is implemented to predict plasma pressure generated by laser-coating interaction in an oil confinement regime. Residual stresses predicted by the finite element model for wLSP reveal higher magnitude and depth of compressive residual stresses than room temperature laser shock peening. A novel dual laser wLSP experimental setup is developed for simultaneous heating of the sample, to a prescribed temperature, and to perform wLSP. The heating laser power is tuned to achieve a predefined temperature in the material through predictive analysis with a 3-D transient laser heating model.Laser welded joints of AA6061-T6 and TZM alloy in bead-on-plate (BOP) and overlap configurations, created by laser welding with a high power fiber laser, were post processed with wLSP. To evaluate the strength of the welded joints pre- and post-processing, tensile testing and tensile-shear testing were carried out. To understand the failure modes in tensile-shear testing of the samples, a 3-D finite element model of the welded joint was developed with weld regions’ material strength properties defined through microhardness testing. The stress concentration regions predicted by the finite element model clearly explain the failure regions in the experimental tensile testing analysis. The tensile tests and tensile-shear tests carried out on wLSP processed AA6061-T6 samples demonstrate an enhancement in the joint strength by about 20% and ductility improvement of about 33% over as-welded samples. The BOP welds of TZM alloy processed with wLSP demonstrated an enhancement in strength by about 30% and lap welds demonstrated an increase in joint strength by 22%.
sj-pdf-1-jht-10.1177_10963480211030313 – Supplemental material for Are hotel guests altruistic? How Positive Review Disconfirmation Affects Consumers’ Online Review Behavior
Creators: name: Li, Hengyun
name: Meng, Fang
name: Hudson, Simon
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business
subject: 150402 Hospitality Management

description: Supplemental material, sj-pdf-1-jht-10.1177_10963480211030313 for Are hotel guests altruistic? How Positive Review Disconfirmation Affects Consumers’ Online Review Behavior by Hengyun Li, Fang Meng and Simon Hudson in Journal of Hospitality & Tourism Research
sj-docx-1-sci-10.1177_00368504211031749 – Supplemental material for HMGCS2 in metabolic pathways was associated with overall survival in hepatocellular carcinoma: A LASSO-derived study
Creators: name: Ding, Rongrong
name: Chen, Tianyou
name: Zhang, Yuan
name: Chen, Xiaorong
name: Zhuang, Liping
name: Yang, Zongguo
Publisher: name: SAGE Journals
Year: 2021
Subjects: Biological Sciences not elsewhere classified

description: Supplemental material, sj-docx-1-sci-10.1177_00368504211031749 for HMGCS2 in metabolic pathways was associated with overall survival in hepatocellular carcinoma: A LASSO-derived study by Rongrong Ding, Tianyou Chen, Yuan Zhang, Xiaorong Chen, Liping Zhuang and Zongguo Yang in Science Progress
Additional file 1 of Clinical virtual simulation: predictors of user acceptance in nursing education
Creators: name: Padilha, José Miguel
name: Costa, Patrício
name: Sousa, Paulino
name: Ferreira, Ana
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Science Policy
subject: Hematology

description: Additional file 1. Descriptive analysis of the TAM item.
sj-pdf-2-hpq-10.1177_13591053211014597 – Financial distress and suicidal behaviour during COVID-19: Family identification attenuates the negative relationship between COVID-related financial distress and mental Ill-health
Creators: name: Stevenson, Clifford
name: Wakefield, Juliet Ruth Helen
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: sj-pdf-2-hpq-10.1177_13591053211014597 for Financial distress and suicidal behaviour during COVID-19: Family identification attenuates the negative relationship between COVID-related financial distress and mental Ill-health by Clifford Stevenson and Juliet Ruth Helen Wakefield in Journal of Health Psychology
Comprehensive safety profile of dipeptidyl peptidase-4 inhibitors: a post-marketing study based on FAERS database using signal detection algorithms
Creators: name: Yoosuf, Beema T
name: Favas, Muhammed
name: Dutta, Pinaki
name: Bansal, Dipika
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: Dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors) have acquired a foothold in managing type 2 diabetes mellitus, but few concerns have arisen regarding their overall safety profile. The aim of this study is to assess the potential risk of DPP-4 inhibitors by analyzing data from the FDA Adverse Event Reporting System (FAERS) database. This is a retrospective study which explored the FAERS database till March 2023 for the collection of safety reports. The disproportionality analysis was performed using signal detection algorithms (SDAs) incorporating frequentist-based data mining approach such as relative reporting ratio (RRR), reporting odds ratio (ROR) and proportional reporting ratio (PRR) with 95% confidence interval (CI). A total of 14,573 adverse event reports were reported in the FAERS public dashboard associated with all the included DPP-4 inhibitors. The computed PRR, ROR, and RRR indicated positive signals for DPP-4 inhibitors with cardiac failure, pancreatitis, pemphigoid, hypoglycemia, acute kidney injury and lactic acidosis. Saxagliptin showed a higher signal score for cardiac failure, while sitagliptin was more associated with pancreatitis. Moreover, alogliptin exhibited an elevated signal score associated with pancreatic carcinoma. Several significant disproportionality signals were observed with DPP-4 inhibitors. However, clinicians have to consider the comorbidities and concomitant drugs while prescribing these drugs.
From types to trees: Reconstructing the spatial spread of Staphylococcus aureus based on DNA variation
Creators: name: Nübel, Ulrich
name: Strommenger, Birgit
name: Layer, Franziska
name: Witte, Wolfgang
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2011
Subjects: subject: MRSA
subject: Phylogeography
subject: MLST
subject: PFGE
subject: spa typing
subject: MLVA
subject: SNPs
subject: 610 Medizin

description: Tracing the spatial spread of pathogens is a key objective of molecular infectious disease epidemiology. Accordingly, a wide range of genotyping approaches have been used to monitor the dissemination of Staphylococcus aureus strains, from localized outbreaks to global spread. We provide a critical review of available methods, revealing that molecular markers currently in use for typing S. aureus acquire changes so slowly that they monitor evolutionary change over timescales that are largely irrelevant to epidemiology. Moreover, the more variable markers frequently do not reflect the pathogen's evolutionary history and, hence, provide potentially misleading information about spread. More recent work has demonstrated that staphylococcal evolution proceeds sufficiently fast that the dynamics of S. aureus spatial spread can be elucidated at great detail on the basis of genome-wide single-nucleotide polymorphisms.
sj-pdf-1-tdo-10.1177_00494755211030165 - Supplemental material for Diagnostic accuracy of Alvarado, RIPASA and Tzanakis scoring system in acute appendicitis: A prospective observational study
Creators: name: Sharma, Pushkar
name: Jain, Ankit
name: Shankar, Gomathi
name: Jinkala, Sreerekha
name: Kumbhar, Uday S
name: Shamanna, Sreenath G
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-1-tdo-10.1177_00494755211030165 for Diagnostic accuracy of Alvarado, RIPASA and Tzanakis scoring system in acute appendicitis: A prospective observational study by Pushkar Sharma, Ankit Jain, Gomathi Shankar, Sreerekha Jinkala, Uday S Kumbhar and Sreenath G Shamanna in Tropical Doctor