cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Mit den Augen des Kindes
Creators: name: Ryszka, Deborah
name: Fuchs, Kevin
Publisher: name: Medienimpulse
Year: 2018

description: Schulunterricht soll digitaler werden, um junge Menschen besser auf eine von Computern und Algorithmen geprägte Welt vorzubereiten. Doch ab welchem Alter und in welcher Form ist dies sinnvoll? Sollten digitale Medien bereits im Grundschulunterricht zum Einsatz kommen? Ziel des folgenden Literature Review ist es diese Fragen zu beantworten. Je nach Altersstufe weisen Kinder ein Ensemble aus bereits erworbenen und noch fehlenden Fähigkeiten auf. Dies bestimmt ihre Wahrnehmung und Interaktion mit der Welt, worin sie sich teilweise erheblich von Erwachsenen unterscheiden. Es ist naheliegend, dass dies auch einen Einfluss darauf hat, wie Kinder digitale Medien wahrnehmen. Obwohl die kognitive Entwicklung von Kindern gut erforscht ist, fehlt in dieser Diskussion nicht nur der Rekurs auf eben diese Erkenntnisse. Vielmehr erfährt das Fehlen dieses Rekurses selbst kaum Beachtung. Dieser Artikel soll mögliche Streitpunkte dieser Thematik aufzeigen. Mithilfe entwicklungspsychologischer Theorien versuchen wir Ansatzpunkte herauszuarbeiten, um zukünftig eine bessere E-Learning-Theorie für Grundschulkinder zu inspirieren.
description: Medienimpulse, Bd. 56 Nr. 3 (2018): 3/2018 - Literaturvermittlung/Digitale Literarizität, Literalität und Literaturproduktion
Spectral modeling of gaseous metal disks around DAZ white dwarfs
Creators: name: Werner, K.
name: Nagel, T.
name: Rauch, T.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We report on our attempt for the first non-LTE modeling of gaseous metal disks around single DAZ white dwarfs recently discovered by Gaensicke et al. and thought to originate from a disrupted asteroid. We assume a Keplerian rotating viscous disk ring composed of calcium and hydrogen and compute the detailed vertical structure and emergent spectrum. We find that the observed infrared CaII emission triplet can be modeled with a hydrogen-deficient gas ring located at R=1.2 R_sun, inside of the tidal disruption radius, with Teff about 6000 K and a low surface mass density of about 0.3 g/cm**2. A disk having this density and reaching from the central white dwarf out to R=1.2 R_sun would have a total mass of 7 10**21 g, corresponding to an asteroid with about 160 km diameter.
description: Proceedings, 16th European White Dwarf Workshop, Barcelona, 2008
Additional file 4 of BAP1 regulates HSF1 activity and cancer immunity in pancreatic cancer
Creators: name: Yuan, Weiwei
name: Zhang, Qiyue
name: Zhao, Yuhan
name: Xia, Wentao
name: Yin, Shilin
name: Liang, Xueyi
name: Chen, Taoyu
name: Li, Gaofeng
name: Liu, Yanshen
name: Liu, Zhiqiang
name: Huang, Jinxi
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Supplementary Material 4
Energy-momentum tensor correlators and viscosity
Creators: name: Meyer, Harvey B.
Publisher: name: arXiv
Year: 2008
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: Collective flow has been observed in heavy ion collisions, with a large anisotropic component, and ideal hydrodynamic calculations had significant successful in describing the distribution of produced particles at the RHIC experiments. In order to account for this near ideal fluid behavior, the shear and bulk viscosity of the quark gluon plasma (QGP) must be computed from first principles in a regime where the QGP is not weakly coupled. In this talk I describe recent progress in computing energy-momentum tensor correlators on the lattice from which the viscosities can be extracted via Kubo formulas. I also show how to cumulate information from several channels, including at non-vanishing spatial momentum, in order to best constrain the viscosities. These methods should soon yield predictions at the higher temperatures that will be explored at the LHC experiments.
description: Plenary talk at 26th International Symposium on Lattice Field Theory (Lattice 2008), Williamsburg, Virginia, USA, July 14 - 19, 2008
Complex variable function Gaussian beam in strongly nonlocal nonlinear media
Creators: name: Deng, Dengmei
name: Guo, Qi
name: Hu, Wei
Publisher: name: arXiv
Year: 2008
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We introduce a novel class of spatial complex variable function Gaussian (CVF-Gaussian) beam, which is the product of an arbitrary analytic complex variable function and a Gaussian function, in strongly nonlocal nonlinear media (SNNM). The CVF-Gaussian beam rotates generally during propagation. By choosing the input power of the beam, we can obtain the CVF-Gaussian breather or the CVF-Gaussian soliton. We reveal that stable CVF-Gaussian beam can exist in SNNM with different forms, including rotating dipole, and rotating elliptic donut. A distribution factor which is the parameter for the description of the transverse distribution of the CVF-Gaussian beam is discussed.
description: This paper has been withdrawn by the authors. 10 pages, 2 figures
Moments of exit times from wedges for non-homogeneous random walks with asymptotically zero drifts
Creators: name: MacPhee, Iain M.
name: Menshikov, Mikhail V.
name: Wade, Andrew R.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60J10 (Primary), 60G40, 60G50 (Secondary)

description: We study quantitative asymptotics of planar random walks that are spatially non-homogeneous but whose mean drifts have some regularity. Specifically, we study the first exit time $τ_α$ from a wedge with apex at the origin and interior half-angle $α$ by a non-homogeneous random walk on the square lattice with mean drift at $x$ of magnitude $O(1/|x|)$ as $|x| \to \infty$. This is the critical regime for the asymptotic behaviour: under mild conditions, a previous result of the authors (see arXiv:0910.1772) stated that $τ_α< \infty$ a.s. for any $α$ (while for a stronger drift field $τ_α$ is infinite with positive probability). Here we study the more difficult problem of the existence and non-existence of moments $E[τ_α^s]$, $s>0$. Assuming (in common with much of the literature) a uniform bound on the walk's increments, we show that for $α< π/2$ there exists $s_0 \in (0,\infty)$ such that $E[τ_α^s]$ is finite for $s < s_0$ but infinite for $s > s_0$; under specific assumptions on the drift field we show that we can attain $E[τ_α^s] = \infty$ for any $s > 1/2$. We show that for $α\leq π$ there is a phase transition between drifts of magnitude $O(1/|x|)$ (the critical regime) and $o(1/|x|)$ (the subcritical regime). In the subcritical regime we obtain a non-homogeneous random walk analogue of a theorem for Brownian motion due to Spitzer, under considerably weaker conditions than those previously given (including work by Varopoulos) that assumed zero drift.
description: 35 pages, 2 figures; most of the material in v1 (which had a different title) appears in revised form in v2 or the companion paper arXiv:0910.1772
Additional file 5 of BAP1 regulates HSF1 activity and cancer immunity in pancreatic cancer
Creators: name: Yuan, Weiwei
name: Zhang, Qiyue
name: Zhao, Yuhan
name: Xia, Wentao
name: Yin, Shilin
name: Liang, Xueyi
name: Chen, Taoyu
name: Li, Gaofeng
name: Liu, Yanshen
name: Liu, Zhiqiang
name: Huang, Jinxi
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Supplementary Material 5
The influence of conversational role on phonetic alignment toward voice-AI and human interlocutors
Creators: name: Zellou, Georgia
name: Cohn, Michelle
name: Kline, Tyler
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Two studies investigated the influence of conversational role on phonetic imitation toward human and voice-AI interlocutors. In a Word List Task, the giver instructed the receiver on which of two lists to place a word; this dialogue task is similar to simple spoken interactions users have with voice-AI systems. In a Map Task, participants completed a fill-in-the-blank worksheet with the interlocutors, a more complex interactive task. Participants completed the task twice with both interlocutors, once as giver-of-information and once as receiver-of-information. Phonetic alignment was assessed through similarity rating, analysed using mixed effects logistic regressions. In the Word List Task, participants aligned to a greater extent toward the human interlocutor only. In the Map Task, participants as giver only aligned more toward the human interlocutor. Results indicate that phonetic alignment is mediated by the type of interlocutor and that the influence of conversational role varies across tasks and interlocutors.
The influence of early and late breeding of dairy cows on fertility, weight changes and on milk production of the present and subsequent lactation
Creators: name: Schneider, F. (Fritz)
Publisher: name: University of British Columbia
Year: 2010

description: In a Holstein herd (125 cows) the influence of early and late breeding post partum on reproduction and production was investigated. At calving the cows were randomly assigned to two groups. The early bred group was scheduled to be bred at the first visible heat following 50 days post partum which resulted in an average interval of 73 ± 18 days from parturition to the first service. The average interval from parturition to conception was 88 ± 33 days. The cows in the early bred group conceived after an average of 1.50 (range: 1 to 3) services per conception. The late bred group was scheduled to be bred at the first visible heat following 80 days post partum which resulted in an average interval of 93 ± 17 days from parturition to the first service. The average interval from parturition to conception was 120 ± 40 days. The cows in the late bred group conceived after an average of 1.96 (range: 1 to 5) services per conception. The number of services per conception was significantly (P£.05) higher for the late bred group. The early post partum reproductive activity was monitored with milk progesterone analyses. A sample of milk strippings was analysed by a radioimmunoassay technique every second day from 6 days post partum until conception occurred or the animal was removed from the herd. Cows which did not conceive were excluded from the statistical analyses. The average length of the first estrous cycle was 17 ± 7.5 days. The first progesterone detected heat occurred 33 ± 10 days post partum compared to the first visible heat which occurred 48 ± 26 days post partum. Calving associated problems and the calving during the pasture season delayed conception in the late bred group but not in the early bred group. The late bred group produced more fat corrected milk (FCM) in the 305 day lactation and in the first 150 days of the subsequent lactation and also gained more (P≤.05) weight between calvings. Cows calving during the pasture season produced more FCM in the 305 day lactation but gained significantly (P≤.01) less weight between calvings than cows calving in the non-pasture season. There was no difference between early and late bred group, health status groups or groups according to the calving season in terms of average daily milk and FCM yield calculated over the entire period of this experiment (beginning of current lactation to day 150 of the subsequent lactation, including the dry period). Calving difficulties and early post partum reproductive problems were not related to production traits.
Concurrent listening affects speech planning and fluency: the roles of representational similarity and capacity limitation
Creators: name: He, Jieying
name: Meyer, Antje S.
name: Brehm, Laurel
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: In a novel continuous speaking-listening paradigm, we explored how speech planning was affected by concurrent listening. In Experiment 1, Dutch speakers named pictures with high versus low name agreement while ignoring Dutch speech, Chinese speech, or eight-talker babble. Both name agreement and type of auditory input influenced response timing and chunking, suggesting that representational similarity impacts lexical selection and the scope of advance planning in utterance generation. In Experiment 2, Dutch speakers named pictures with high or low name agreement while either ignoring Dutch words, or attending to them for a later memory test. Both name agreement and attention demand influenced response timing and chunking, suggesting that attention demand impacts lexical selection and the planned utterance units in each response. The study indicates that representational similarity and attention demand play important roles in linguistic dual-task interference, and the interference can be managed by adapting when and how to plan speech.
Importance of dxy orbital and electron correlation in iron-based superconductors revealed by phase diagram for 1111-system
Creators: name: Kawashima, T.
name: Miyasaka, S.
name: Tsuji, H.
name: Yamamoto, T.
name: Uekubo, M.
name: Takemori, A.
name: Lai, K. T.
name: Tajima, S.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The structural flexibility at three substitution sites in LaFeAsO enabled investigation of the relation between superconductivity and structural parameters over a wide range of crystal compositions. Substitutions of Nd for La, Sb or P for As, and F or H for O were performed. All these substitutions modify the local structural parameters, while the F/H-substitution also changes band filling. It was found that the superconducting transition temperature $T_{c}$ is strongly affected by the pnictogen height $h_{Pn}$ from the Fe-plane that controls the electron correlation strength and the size of the $d_{xy}$ hole Fermi surface (FS). With increasing $h_{Pn}$, weak coupling superconductivity switches to the strong coupling one where the $d_{xy}$ hole FS is crucially important.
description: 10 pages, 6 figures. This is a preprint of an article published in Scientific Reports. The final authenticated version is available online at: https://doi.org/10.1038/s41598-021-89231-2
Microscopic diagonal entropy and its connection to basic thermodynamic relations
Creators: name: Polkovnikov, Anatoli
Publisher: name: arXiv
Year: 2008
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: High Energy Physics - Theory (hep-th)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We define a diagonal entropy (d-entropy) for an arbitrary Hamiltonian system as $S_d=-\sum_n ρ_{nn}\ln ρ_{nn}$ with the sum taken over the basis of instantaneous energy states. In equilibrium this entropy coincides with the conventional von Neumann entropy $S_n=-{\rm Tr}\, ρ\lnρ$. However, in contrast to $S_n$, the d-entropy is not conserved in time in closed Hamiltonian systems. If the system is initially in stationary state then in accord with the second law of thermodynamics the d-entropy can only increase or stay the same. We also show that the d-entropy can be expressed through the energy distribution function and thus it is measurable, at least in principle. Under very generic assumptions of the locality of the Hamiltonian and non-integrability the d-entropy becomes a unique function of the average energy in large systems and automatically satisfies the fundamental thermodynamic relation. This relation reduces to the first law of thermodynamics for quasi-static processes. The d-entropy is also automatically conserved for adiabatic processes. We illustrate our results with explicit examples and show that $S_d$ behaves consistently with expectations from thermodynamics.
description: revised and expanded as published, clarified common misconceptions about additivity of the entropy
Spectrum-Energy Correlations and Swift GRBs
Creators: name: Amati, Lorenzo
Publisher: name: arXiv
Year: 2008
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The correlation between the photon energy at which the redshift corrected nFn spectrum peaks (hence called "peak energy", Ep,i) and the isotropic equivalent radiated energy (Eiso), is one of the most intriguing and debated observational evidences in Gamma- Ray Bursts (GRB) astrophysics. In order to fully exploit this correlation to understand GRB physics and use them as a cosmological tool, we need to understand and reduce selection effects and biases in the sample of GRBs with known redshift. The Swift satellite, thanks to its scientific payload and unprecedented slewing capabilities, is providing us new observational evidences and a reduction of selection effects in the process of GRB redshift estimate. I discuss the location of Swift GRBs in the Ep,i-Eiso plane and the main implications, with particular emphasis on selection effects, the existence and nature of sub-energetic long GRBs, the GRB-SN connection, the difference between long and short GRBs and the recently discovered sub-class of long GRBs without association with a hypernova. I also briefly review the impact of Swift observations on 3-parameters spectrum-energy correlations, which have been proposed as a potentially powerful tool to standardize GRBs for the estimate of cosmological parameters.
description: 4 pages, 2 figures, Figure 1 and references have been updated with respect to published paper
Learning analytics and its metrics – approaching an educational frame via a social semiotic pathway
Creators: name: Bachmair, Ben
name: Turvey, Keith
name: Cook, John
name: Pachler, Norbert
Publisher: name: Medienimpulse
Year: 2018

description: Learning Analytics und ihre Metriken – Annäherung an einen pädagogischen Rahmen über einen sozialsemiotischen Weg Der Beitrag stellt sich die Aufgabe, Metriken auf Bildung anzuwenden und schlägt dazu vor, Lernanalytik und ihre metrischen Verfahren in ein sozialsemiotisches Konzept von Lernen als Entwicklung von Bedeutung einzuordnen. Solch ein sozialsemiotischen Rahmen definiert Metriken als eine qualitative und quantitative Modalität der Repräsentation von Lernpraxis, die empirische Belege von und für pädagogische Praxis bietet. Arbeiten aus den Bereichen der Kulturwissenschaften und Medienwissenschaften der 1970er Jahren, die TV-vermittelte Massenkommunikation als Bedeutung konstituierende Praktiken definierte, dienen als Anregung, um Metriken als einen Repräsentationsmodus in und von Bildungsprozessen zu bestimmen. Dabei gilt es zu bedenken, dass Bildung zunehmend mit den Auswirkungen der Digitalisierung und mit der dazu gehörigen Automatisierung konfrontiert ist. Aufgabe von Pädagogik ist nun, Metriken sinnvoll für Lernen aufzubereiten, indem Metriken und Metrifizierung der Dynamik der persönlichen Entwicklung einer/s Lernenden sowie derer bzw. dessen Entwicklungskontext gerecht werden. Das ist vor allem eine pädagogische Aufgabe und keine, die sich auf Verwertbarkeit ausrichtet. Der Beitrag schlägt dazu vor, Metriken als einen Repräsentationsmodus von Lernprozessen und Lernergebnissen zu bestimmen. Hilfreich ist dabei, sich auf Narrative als einen Repräsentationsmodus von Lernprozessen und Lernergebnissen zu konzentrieren, nicht zuletzt, weil Narrative eine vertraute Form von Reflexivität bieten. Darüber hinaus schlägt der Beitrag vor, Lernpraktiken als eine Form von Context Awareness zu sehen, was mit Beispielen aus Grundschule und Universität veranschaulicht wird.
description: Medienimpulse, Bd. 56 Nr. 3 (2018): 3/2018 - Literaturvermittlung/Digitale Literarizität, Literalität und Literaturproduktion
Thermal Trigger for Solar Flares III: Effect of the Oblique Layer Fragmentation
Creators: name: Ledentsov, Leonid
Publisher: name: arXiv
Year: 2021
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: We consider the oblique fragmentation of the current layer as a result of the thermal instability described in Ledentsov (Sol. Phys. 296, 74, 2021a). It is shown that the fragmentation transverse to the current is a natural feature of the model. The fragmentation tilt does not exceed a few degrees for realistic preflare parameters of the coronal plasma. As a consequence, oblique fragmentation generally does not have a strong impact on the simulation results, however, extreme changes can reach an order of magnitude. Thus, oblique fragmentation can lead to a decrease in the estimate of the spatial period of the location of elementary energy release in solar flares to 0.1-1 Mm instead of 1-10 Mm obtained earlier.
description: This is a post-peer-review, pre-copyedit version of an article published in Solar Physics
Digitale Grundbildung im Pilotversuch
Creators: name: Swertz, Christian
Publisher: name: Medienimpulse
Year: 2018

description: Die im Schuljahr 2018/2019 erfolgende flächendeckende Einführung der verbindlichen Übung "Digitale Grundbildung" in Österreich wurde im Schuljahr 2017/2018 mit einem Pilotversuch vorbereitet. In 15 der beteiligten Schulen wurden Lehrende und Lernende zu ihren Erfahrungen befragt und Unterrichtsstunden beobachtet. Die Ergebnisse zeigen, dass vor allem die Verständigung in den Kollegien und bereits vorliegende Erfahrungen Erfolgsfaktoren sind. Probleme mit der Geräteausstattung konnten kaum beobachtet werden. Als problematisch erwiesen sich in den beobachteten Schulen fehlende Materialien und Kompetenzen für die Vermittlung von Medienkompetenz und digitalen Kompetenzen (Fachdidaktik Informatik). Das gilt sowohl für die Integration in die Fächer als auch für gewidmete Stunden. Damit wird als Aufgabe für die Medienpädagogik und die Fachdidaktik Informatik interpretiert.
description: Medienimpulse, Bd. 56 Nr. 3 (2018): 3/2018 - Literaturvermittlung/Digitale Literarizität, Literalität und Literaturproduktion
Syntactic representations encode grammatical functions: evidence from the priming of mapping between grammatical functions and thematic roles in Cantonese
Creators: name: Song, Yoonsang
name: Lai, Ryan K. Y.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Neuroscience
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: A structural priming study examined whether the mapping between grammatical functions (e.g. subject) and thematic roles (e.g. agent) persists across utterances. Specifically, we tested whether native Cantonese speakers are more likely to produce a standard subject–verb–object (SVO) active or a standard passive sentence after repeating an active sentence in object–subject–verb (OSV) order where the direct object (i.e. patient) is grammatically marked as a topic. Such Topic-OSV and standard active sentences share the same agent–subject and patient–direct object mapping, but they differ in all other important aspects including constituent structure, information structure, and linear thematic role order. In contrast, Topic-OSV and passive sentences only share information structure and thematic role order. The results demonstrated that Topic-OSV prime sentences primed SVO actives rather than passives, suggesting that grammatical function–thematic role mapping is a major source of structural priming. We thus argue that our sentence representations encode grammatical functions.
eReader: Leicht und praktisch und digital Lesen?
Creators: name: Berger, Christian
Publisher: name: Medienimpulse
Year: 2018

description: Medienimpulse, Bd. 56 Nr. 3 (2018): 3/2018 - Literaturvermittlung/Digitale Literarizität, Literalität und Literaturproduktion
Erstes Algorithmisieren über die Darstellung von Bewegungen mittels grafischer Symbole
Creators: name: Wagner, Wolfgang
Publisher: name: Medienimpulse
Year: 2018

description: Eine Auseinandersetzung mit digitalen Medien, die zunehmend unser Leben mitgestalten, ist notwendig, um eine mündige und kritische Nutzung zu ermöglichen. Ein Verständnis über Algorithmisierungen, als Basis für die Funktion von Programmen, ist bereits im Kindergarten- bzw. Grundschulalter möglich [1] . Dieser Zugang hat für alle Kinder zu erfolgen. Ein Aufbau dieses Verständnisses für alle Kinder auf der Repräsentationsstufe der Handlung mit darauf folgenden Intermodalitätswechsel zur bildhaften und symbolhaften Ebene ermöglicht eine Automatisierung basierend auf dem Verständnis einer Grundvorstellung [2] . Im Artikel wird ein Ablauf vorgestellt, wie Kinder in frühem Alter, basierend am eigenem Tun, Denkprozesse entwickeln, mit denen sie einfache Programme mit den Befehlen FORWARD, BACKWARD, LEFT-TURN UND RIGHT-TURN [3] erstellen können. Im Sinne des konstruktivistischen Lernens und im speziellen des konstruktionistischen Lernens [4] ist es Ziel, eine Grundvorstellung des Programmierens zu generieren. Programmbefehle sind keine toten Symbole [5] , sondern mit Handlung verbundene Zeichen. Die konstruktivistische Vorgangsweise und einer damit verbundenen inneren Differenzierung ermöglichen den Aufbau eines Verständnisses des Programmierens im inklusiven Sinne für alle Kinder.
description: Medienimpulse, Bd. 56 Nr. 3 (2018): 3/2018 - Literaturvermittlung/Digitale Literarizität, Literalität und Literaturproduktion
Erziehung und Öffentlichkeit bei John Dewey
Creators: name: Lasser, Bernhard
Publisher: name: Medienimpulse
Year: 2018

description: Medienimpulse, Bd. 56 Nr. 3 (2018): 3/2018 - Literaturvermittlung/Digitale Literarizität, Literalität und Literaturproduktion
Antiviral activity of traditional medicinal plants from Ayurveda against SARS-CoV-2 infection
Creators: name: Maurya, Vimal K.
name: Kumar, Swatantra
name: Bhatt, Madan L. B.
name: Saxena, Shailendra K.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: SARS-CoV-2 is the etiological agent of COVID-19 and responsible for more than 6 million cases globally, for which no vaccine or antiviral is available. Therefore, this study was planned to investigate the antiviral role of the active constituents against spike glycoprotein of SARS-CoV-2 as well as its host ACE2 receptor. Structure-based drug design approach has been used to elucidate the antiviral activity of active constituents present in traditional medicinal plants from Ayurveda. Further, parameters like drug-likeness, pharmacokinetics, and toxicity were determined to ensure the safety and efficacy of active constituents. Gene network analysis was performed to investigate the pathways altered during COVID-19. The prediction of drug–target interactions was performed to discover novel targets for active constituents. The results suggested that amarogentin, eufoliatorin, α-amyrin, caesalpinins, kutkin, β-sitosterol, and belladonnine are the top-ranked molecules have the highest affinity towards both the spike glycoprotein and ACE2. Most active constituents have passed the criteria of drug-likeness and demonstrated good pharmacokinetic profile with minimum predicted toxicity level. Gene network analysis confirmed that G-protein coupled receptor, protein kinase B signaling, protein secretion, peptidyl-serine phosphorylation, nuclear transport, apoptotic pathway, tumor necrosis factor, regulation of angiotensin level, positive regulation of ion transport, and membrane protein proteolysis were altered during COVID-19. The target prediction analysis revealed that most active constituents target the same pathways which are found to be altered during COVID-19. Collectively, our data encourages the use of active constituents as a potential therapy for COVID-19. However, further studies are ongoing to confirm its efficacy against disease. Communicated by Ramaswamy H. Sarma
Überlegungen zur technologisierten Gesellschaft, zu technologiemündigen Subjekten und der Rolle der Werkerziehung
Creators: name: Zobl, Cornelia
Publisher: name: Medienimpulse
Year: 2018

description: Medienimpulse, Bd. 56 Nr. 3 (2018): 3/2018 - Literaturvermittlung/Digitale Literarizität, Literalität und Literaturproduktion
New insight into the molecular mechanism of the trehalose effect on urate oxidase stability
Creators: name: Taherimehr, Zahra
name: Zaboli, Maryam
name: Torkzadeh-Mahani, Masoud
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Plant Biology
subject: Computational Biology

description: Urate oxidase (EC 1.7.3.3) is a key enzyme in the purine metabolism which is applied in the treatment of gout and also, as a diagnostic reagent for uric acid detection. In the current study, the trehalose (TRE) effects as an additive on the structural stability and function of uricase were investigated. For recombinant expression of UOX in E. coli BL21 cells, firstly the coding sequence was subcloned into the pET-28a vector and after induction with IPTG, the recombinant UOX was purified by affinity chromatography using a Ni-NTA agarose column. To specify the trehalose effects on the urate oxidase (UOX) structure, optimum pH, optimum temperature, kinetic and thermodynamic parameters and also, the intrinsic fluorescence of UOX in the absence and presence of trehalose were examined. The UOX half-life is 24.32 min at 40 °C, whereas the UOX-TRE has a higher half-life (32.09 min) at this temperature. Generally, our findings confirm that trehalose has a protective effect on the enzyme structure. Optimum pH and temperature were 9 and 25 °C, respectively for both the naked and treated enzymes and their activity retained 42.18 and 64.80%, respectively after 48 h of incubation at room temperature. Also, theoretical results indicate that the random coil of the enzyme was converted to α-helix and β-sheet in the presence of trehalose which may preserve the integrity of the active site of the enzyme and increased the enzymatic activity. The MD simulation results indicated greater stability of the uricase structure in the presence of trehalose. Communicated by Ramaswamy H. Sarma
Rezension: Die Welt ist Bühne: Karlheinz Böhm. Die Biographie
Creators: name: Rogy, Raffaela
Publisher: name: Medienimpulse
Year: 2018

description: Medienimpulse, Bd. 56 Nr. 3 (2018): 3/2018 - Literaturvermittlung/Digitale Literarizität, Literalität und Literaturproduktion
Additional file 6 of BAP1 regulates HSF1 activity and cancer immunity in pancreatic cancer
Creators: name: Yuan, Weiwei
name: Zhang, Qiyue
name: Zhao, Yuhan
name: Xia, Wentao
name: Yin, Shilin
name: Liang, Xueyi
name: Chen, Taoyu
name: Li, Gaofeng
name: Liu, Yanshen
name: Liu, Zhiqiang
name: Huang, Jinxi
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Supplementary Material 6
Estimation of conditional laws given an extreme component
Creators: name: Fougères, Anne-Laure
name: Soulier, Philippe
Publisher: name: arXiv
Year: 2008
Subjects: subject: Statistics Theory (math.ST)
subject: FOS: Mathematics

description: Let $(X,Y)$ be a bivariate random vector. The estimation of a probability of the form $P(Y\leq y \mid X >t) $ is challenging when $t$ is large, and a fruitful approach consists in studying, if it exists, the limiting conditional distribution of the random vector $(X,Y)$, suitably normalized, given that $X$ is large. There already exists a wide literature on bivariate models for which this limiting distribution exists. In this paper, a statistical analysis of this problem is done. Estimators of the limiting distribution (which is assumed to exist) and the normalizing functions are provided, as well as an estimator of the conditional quantile function when the conditioning event is extreme. Consistency of the estimators is proved and a functional central limit theorem for the estimator of the limiting distribution is obtained. The small sample behavior of the estimator of the conditional quantile function is illustrated through simulations.
description: 32 pages, 5 figure
Molecular dynamics analysis predicts ritonavir and naloxegol strongly block the SARS-CoV-2 spike protein-hACE2 binding
Creators: name: Bagheri, Milad
name: Niavarani, Ahmadreza
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: The rapid emergence of COVID-19 pandemics has posed humans particularly vulnerable to the novel SARS-CoV-2 virus. Since de novo drug discovery is both expensive and time-consuming, drug repurposing approaches are believed to be of particular help. The SARS-CoV-2 spike (S) protein is known to attach human angiotensin-converting enzyme-2 (hACE2) through its receptor-binding domain (RBD). We screened 1930 FDA-approved ligands for the selection of optimal ones blocking this interaction. Virtual screening predicted top 25 ligands docking to any of the reported binding sites. After exclusion of those ligands which were unsuitable for systemic use, the remaining 69 RBD-ligand complexes were screened based on the masking capacity of the amino acid residues engaged in RBD-hACE2 interaction, excluding 47 RBD-ligand complexes. A short molecular dynamics (MD) simulation analysis identified 11 globally stable complexes with the lowest RMSD (root-mean-square deviation). Next, a moderately long MD analysis revealed those six RBD-ligand complexes with the lowest RMSD variation, as a measure of global stability. Finally, a long MD analysis revealed two select candidate ligands, including ritonavir and naloxegol, highly stabilizing those key residues engaged in RBD-hACE2 interaction. A similar MD analysis of a few antiviral drugs which are under clinical trials or approved for COVID-19 treatment showed them inferior to both select ligands in terms of stabilizing the RBD globally and locally at binding sites. Because of the crucial role of the S protein in virus virulence, our results highly propose ritonavir and naloxegol as the potentially helpful therapeutics against COVID-19, mandating appropriate clinical trials. Communicated by Ramaswamy H. Sarma
Interpersonal trust: the role of risk in trust behaviour
Creators: name: Charlesworth, Maxine Anne
Publisher: name: University of British Columbia
Year: 2010

description: The first two experiments examined the relationship between risk and trust behaviour in two field situations. The third experiment was a replication of Wright, Maggied, and Palmer (1975). A conceptualization of trust, which included the factors: disposition, risk assessment (level of risk and interpersonal variables), and behavioural intention was outlined. The subject group was composed of 240 female undergraduates enlisted on the premises of the main library at the University of Victoria, Canada. In the first two experiments, a between groups' trust behaviour was compared over conditions of low and high manipulated risk. In both experiments, trust behaviour, which was found to vary significantly over risk conditions, was compared with ratings of risk assessment and scores obtained on Rotter's Interpersonal Trust Scale (ITS). Preliminary indications are that trust behaviour is not significantly related to risk-taking as reflected by subjects' choice of prize for completing the experiment. The third experiment did not replicate the results of Wright, et al. (1975) and showed no relationship between the number and type of questions asked by high or low scorers on the ITS.
Rezension: Leben lesen. Zur Theorie der Biografie um 1800
Creators: name: Lenhart, Johanna
Publisher: name: Medienimpulse
Year: 2018

description: Medienimpulse, Bd. 56 Nr. 3 (2018): 3/2018 - Literaturvermittlung/Digitale Literarizität, Literalität und Literaturproduktion
Nonthermal fixed points and the functional renormalization group
Creators: name: Berges, J.
name: Hoffmeister, G.
Publisher: name: arXiv
Year: 2008
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Other Condensed Matter (cond-mat.other)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Nonthermal fixed points represent basic properties of quantum field theories, in addition to vacuum or thermal equilibrium fixed points. The functional renormalization group on a closed real-time path provides a common framework for their description. For the example of an O(N) symmetric scalar theory it reveals a hierarchy of fixed point solutions, with increasing complexity from vacuum and thermal equilibrium to nonequilibrium.
description: 32 pages, Nucl. Phys. B version (minor changes of wordings)
Additional file 7 of BAP1 regulates HSF1 activity and cancer immunity in pancreatic cancer
Creators: name: Yuan, Weiwei
name: Zhang, Qiyue
name: Zhao, Yuhan
name: Xia, Wentao
name: Yin, Shilin
name: Liang, Xueyi
name: Chen, Taoyu
name: Li, Gaofeng
name: Liu, Yanshen
name: Liu, Zhiqiang
name: Huang, Jinxi
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Supplementary Material 7
Rezension: Grundriss der Literaturwissenschaft
Creators: name: Pagani, Roland
Publisher: name: Medienimpulse
Year: 2018

description: Medienimpulse, Bd. 56 Nr. 3 (2018): 3/2018 - Literaturvermittlung/Digitale Literarizität, Literalität und Literaturproduktion
title: Front Matter, Table of Contents, Preface, Conference Organization
Creators: name: Bramas, Quentin
name: Gramoli, Vincent
name: Milani, Alessia
Publisher: name: Schloss Dagstuhl – Leibniz-Zentrum für Informatik
Year: 2022
Subjects: subject: Front Matter
subject: Table of Contents
subject: Preface
subject: Conference Organization
subject: Theory of computation → Distributed computing models
subject: Theory of computation → Distributed algorithms
subject: Theory of computation → Concurrent algorithms
subject: Theory of computation → Data structures design and analysis
subject: Networks → Mobile networks
subject: Networks → Wireless access networks
subject: Networks → Ad hoc networks
subject: Computing methodologies → Distributed algorithms
subject: Security and privacy → Distributed systems security
subject: Information systems → Distributed storage
subject: Computer systems organization → Dependable and fault-tolerant systems and networks
subject: Software and its engineering → Distributed systems organizing principles

description: Front Matter, Table of Contents, Preface, Conference Organization
description: LIPIcs, Vol. 217, 25th International Conference on Principles of Distributed Systems (OPODIS 2021), pages 0:i-0:xvi
Das Archiv für emanzipatorische Praxen
Creators: name: Höllwart, Renate
name: Trafo.K, Büro
Publisher: name: Medienimpulse
Year: 2018

description: Welche Strategien können wir einsetzen, um Selbstverständnisse und Routinen des "Lernens" zu unterbrechen? Und was können wir voneinander lernend verlernen? Diesen Fragen widmet sich das Büro trafo.K in vielen Projekten. Das Wiener Büro für Kunstvermittlung und kritische Wissensproduktion stellt im Folgenden ihr emanzipatorisches Online-Archiv vor, das sich gleichzeitig kritisch mit den Sammeln, Ordnen und Archivieren beschäftigt.
description: Medienimpulse, Bd. 56 Nr. 3 (2018): 3/2018 - Literaturvermittlung/Digitale Literarizität, Literalität und Literaturproduktion
Additional file 8 of BAP1 regulates HSF1 activity and cancer immunity in pancreatic cancer
Creators: name: Yuan, Weiwei
name: Zhang, Qiyue
name: Zhao, Yuhan
name: Xia, Wentao
name: Yin, Shilin
name: Liang, Xueyi
name: Chen, Taoyu
name: Li, Gaofeng
name: Liu, Yanshen
name: Liu, Zhiqiang
name: Huang, Jinxi
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Supplementary Material 8
Medienperformanz als didaktisches Prinzip medienpädagogischer Praxis
Creators: name: Roth-Ebner, Caroline
name: Duller, Nicole
Publisher: name: Medienimpulse
Year: 2018

description: Die medienpädagogische Diskussion wird stark vom Konzept der Medienkompetenz dominiert. Der Ansatz der Medienperformanz als Manifestation der kognitiven Dispositionen im konkreten auf Medien bezogenen Handeln ist demgegenüber unterbelichtet. In diesem Aufsatz wird diskutiert, wie die beiden Konzepte in medienpädagogischer Praxis aufeinander bezogen werden können. Dabei wird Medienperformanz als didaktische Grundhaltung konzipiert, welche mit den Prinzipien einer handlungs- bzw. alltagsorientierten Medienpädagogik korrespondiert. Am Beispiel des medienpädagogischen Projekts "Schaut her! Ich zeig's euch digital!" wird das didaktische Potenzial des Medienperformanz-Ansatzes dargelegt.
description: Medienimpulse, Bd. 56 Nr. 4 (2018): 4/2018 - Medienkompetenz und Medienperformanz
Nepticulini Stainton 1854
Creators: name: Pohl, Greg
name: Anweiler, Gary
name: Schmidt, Christian
name: Kondla, Norbert
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Nepticulidae

description: Nepticulini 9 * R Stigmella fuscotibiella (Clemens, 1862) E Jun – B – T: Newton and Wilkinson (1982) L: None C: POHL 10 * U Stigmella populetorum (Frey and Boll, 1878) L Jun – B – T: Newton and Wilkinson (1982) L: None C:?POHL Trifurculini 10.1 * P Ectoedemia canadensis (Braun, 1914)? M – – T: Wilkinson (1981) 11 * R Ectoedemia weaveri (Stainton, 1855) M Jul – E Aug – B – T: van Nieukerken (1986), Parenti (2000) L: Macaulay and Pohl (2005) C: NFRC
description: Published as part of Pohl, Greg, Anweiler, Gary, Schmidt, Christian & Kondla, Norbert, 2010, An annotated list of the Lepidoptera of Alberta, Canada, pp. 1-549 in ZooKeys 38 (38) on page 50, DOI: 10.3897/zookeys.38.383, http://zenodo.org/record/576629
description: {"references": ["Newton PJ, Wilkinson C (1982) A taxonomic revision of the North American species of Stigmella (Lepidoptera: Nepticulidae). Systematic Entomology 7: 367 - 463.", "van Nieukerken EJ (1986) Systematics and phylogeny of holarctic genera of Nepticulidae. Zoologische Verhandlingen (Leiden) 236: 1 - 93.", "Parenti U (2000) A guide to the microlepidoptera of Europe. Museo Regionale di Scienze Naturali Torino, Torino, Italy, 426 pp.", "Macaulay D, Pohl GR (2005) Survey of the Lepidoptera fauna in Birch Mountains Wildland Provincial Park. Report prepared for the Alberta Community Development, Parks and Protected Areas Division, Alberta Natural Heritage Information Centre, Edmonton, AB, 13 pp. + appendices. Also available at http: // www. biology. ualberta. ca / old _ site / uasm / alg / projects / inventory _ faunal. html subarctic"]}
EXAMINING CAL STATE FULLERTON'S STUDENT COMMUNICATION RESPONSE TO THE COVID-19 PANDEMIC
Creators: name: Lance, Zoe
Publisher: name: Zenodo
Year: 2021
Subjects: student communication
higher education
COVID-19
crisis communication

description: This case study documents a large, 4-year university’s transition to virtual instruction from January 2020 to June 2021 as a result of the COVID-19 pandemic. Using the situational crisis communication theoretical framework (Coombs, 2019), this analysis explores the university’s student communication response to the pandemic and a primarily virtual academic year. Based on email communications, social media posts, and interviews, there is evidence that students have new expectations for their universities of how to act and support them in a crisis of a global scale. Implications for how universities should respond to future crises using their COVID-19 pandemic experience are discussed. The case study also includes recommendations on managing future crisis communication at institutions and how to engage students as a stakeholder group on a university campus.
Im Schatten der Performanz
Creators: name: Redecker, Anke
Publisher: name: Medienimpulse
Year: 2018

description: Ausgehend von Dieter Baackes Differenzierung zwischen sprachlicher Kompetenz und Performanz lässt sich, an Bernhard Waldenfels anknüpfend, erläutern, dass die Performanz des Gesprochenen oder Geschriebenen eine nicht zur Sprache kommende Innenseite des Ausdrucks verbirgt, der eine Kompetenz anhaften kann, die es in pädagogischer Interaktion zu würdigen und zu fördern gilt. Zugleich ist „im Schatten der Performanz“ auch mit verschiedenen Quellen ungewollter Expositionen zu rechnen. Beim interaktiven Lernen im Raum des Digitalen, wie es zum Beispiel durch Chatrooms und E-Portfolios möglich wird, potenzieren sich die Praktiken des lernhinderlichen Verbergens und ungewollten Aufdeckens unter dem Druck des always on und anytime anywhere . Dass wir generell unser Erleben nicht bruchlos in sprachlichen Ausdruck überführen können und stets mit einem Überschuss des Gemeinten und Gesagten rechnen müssen, kann im Ausgang von der durch Richard Hönigswalds akzentuierten Differenz zwischen Sinn- und Gestaltganzheit, Denken und Sprechen aufgezeigt werden, um schließlich die uns und anderen fremd bleibende Innenseite des Ausdrucks, die auch bei ungewollten Offenbarungen nicht restlos nach außen gekehrt wird, mit Bernhard Waldenfels als eine schützenswerte und zugleich Interaktion ermöglichende Fremdheit zu würdigen. Eine medien- und gezielt sprachkritische Herangehensweise kann hier auf einen verantwortlichen Umgang mit verschiedenen Schattierungen des Performativen aufmerksam machen.
description: Medienimpulse, Bd. 56 Nr. 4 (2018): 4/2018 - Medienkompetenz und Medienperformanz
Supersymmetric Grand Unification and Lepton Universality in K-> l νDecays
Creators: name: Ellis, John
name: Lola, Smaragda
name: Raidal, Martti
Publisher: name: arXiv
Year: 2008
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Motivated by the prospects for an improved test of lepton universality in K -> l νdecays by the NA62 experiment at CERN, we study predictions for the possible lepton non-universality in K -> l νdecays in supersymmetric models. Violations of μ-e universality in this process may originate from mixing effects in the right-handed slepton sector, providing a unique window into this aspect of supersymmetric flavour physics in the large-\tanβregion. Minimal unification scenarios with universal soft supersymmetry-breaking terms at the GUT scale would predict negligible violation of lepton universality. However, lepton non-universality may be observable in non-minimal grand unified models with higher-dimensional terms contributing to fermion masses, in which case renormalization effects above the GUT scale may enhance the mixing among the right-handed sleptons. This could leads to observable lepton non-universality in K -> l νdecays in specific regions of the parameter space with high \tan β, large A terms and small charged Higgs boson mass. Observable non-universality in K -> l νdecays would be correlated with a large value of BR(τ-> e γ). The experimental upper limit on the electric dipole moment of the electron could be reconciled with leptogenesis, if the latter occurs at a relatively low scale, which would also alleviate the cosmological gravitino problem. Even if lepton non-universality is not seen in the near future, one may nevertheless obtain significant constraints on the model parameters and unknown aspects of right-handed fermion and sfermion mixing.
description: 19 pages, 3 figures