Transferrin-decorated niosomes with integrated inp/zns quantum dots and magnetic iron oxide nanoparticles: Dual targeting and imaging of glioma
Creators: name: Seleci, Didem Ag
name: Maurer, Viktor
name: Barlas, Firat Baris
name: Porsiel, Julian Cedric
name: Temel, Bilal
name: Ceylan, Elcin
name: Timur, Suna
name: Stahl, Frank
name: Scheper, Thomas
name: Garnweitner, Georg
Publisher: name: Basel : MDPI
Year: 2021
Subjects: subject: Glioma imaging
subject: Iron oxide nanoparticles
subject: Multifunctional niosomes
subject: Quantum dots
subject: indium
subject: indium phosphide
subject: magnetic iron oxide nanoparticle
subject: magnetic nanoparticle
subject: niosome
subject: quantum dot
subject: transferrin
subject: unclassified drug
subject: zinc sulfide
subject: contrast medium
subject: ferric ion
subject: ferric oxide
subject: liposome
subject: macrogol
subject: nanoparticle
subject: Article
subject: contrast enhancement
subject: controlled study
subject: drug formulation
subject: flow cytometry
subject: fluorescence intensity
subject: fluorescence microscopy
subject: glioma
subject: glioma cell
subject: human
subject: human cell
subject: in vitro study
subject: nanoencapsulation
subject: neuroimaging
subject: nuclear magnetic resonance imaging
subject: transmission electron microscopy
subject: animal
subject: chemistry
subject: diagnostic imaging
subject: genetics
subject: magnetism
subject: metabolism
subject: procedures
subject: tumor cell line
subject: Animals
subject: Cell Line, Tumor
subject: Contrast Media
subject: Ferric Compounds
subject: Glioma
subject: Humans
subject: Liposomes
subject: Magnetic Iron Oxide Nanoparticles
subject: Magnetic Resonance Imaging
subject: Magnetics
subject: Microscopy, Electron, Transmission
subject: Nanoparticles
subject: Polyethylene Glycols
subject: Quantum Dots
subject: Transferrin
subject: Dewey Decimal Classification::500 | Naturwissenschaften::570 | Biowissenschaften, Biologie
subject: Dewey Decimal Classification::500 | Naturwissenschaften::540 | Chemie

description: The development of multifunctional nanoscale systems that can mediate efficient tumor targeting, together with high cellular internalization, is crucial for the diagnosis of glioma. The combination of imaging agents into one platform provides dual imaging and allows further surface modification with targeting ligands for specific glioma detection. Herein, transferrin (Tf)-decorated niosomes with integrated magnetic iron oxide nanoparticles (MIONs) and quantum dots (QDs) were formulated (PEGNIO/QDs/MIONs/Tf) for efficient imaging of glioma, supported by magnetic and active targeting. Transmission electron microscopy confirmed the complete co-encapsulation of MIONs and QDs in the niosomes. Flow cytometry analysis demonstrated enhanced cellular uptake of the niosomal formulation by glioma cells. In vitro imaging studies showed that PEG-NIO/QDs/MIONs/Tf produces an obvious negative-contrast enhancement effect on glioma cells by magnetic resonance imaging (MRI) and also improved fluorescence intensity under fluorescence microscopy. This novel platform represents the first niosome-based system which combines magnetic nanoparticles and QDs, and has application potential in dual-targeted imaging of glioma. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.