cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Semantics derived automatically from language corpora contain human-like biases
Creators: name: Caliskan, Aylin
name: Bryson, Joanna J.
name: Narayanan, Arvind
Publisher: name: arXiv
Year: 2016
Subjects: subject: Artificial Intelligence (cs.AI)
subject: Computation and Language (cs.CL)
subject: Computers and Society (cs.CY)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Artificial intelligence and machine learning are in a period of astounding growth. However, there are concerns that these technologies may be used, either with or without intention, to perpetuate the prejudice and unfairness that unfortunately characterizes many human institutions. Here we show for the first time that human-like semantic biases result from the application of standard machine learning to ordinary language---the same sort of language humans are exposed to every day. We replicate a spectrum of standard human biases as exposed by the Implicit Association Test and other well-known psychological studies. We replicate these using a widely used, purely statistical machine-learning model---namely, the GloVe word embedding---trained on a corpus of text from the Web. Our results indicate that language itself contains recoverable and accurate imprints of our historic biases, whether these are morally neutral as towards insects or flowers, problematic as towards race or gender, or even simply veridical, reflecting the {\em status quo} for the distribution of gender with respect to careers or first names. These regularities are captured by machine learning along with the rest of semantics. In addition to our empirical findings concerning language, we also contribute new methods for evaluating bias in text, the Word Embedding Association Test (WEAT) and the Word Embedding Factual Association Test (WEFAT). Our results have implications not only for AI and machine learning, but also for the fields of psychology, sociology, and human ethics, since they raise the possibility that mere exposure to everyday language can account for the biases we replicate here.
description: 14 pages, 3 figures
Metodología para implementar una infraestructura de red que soporte servicios webcast para apoyo docente en la Universidad de Cartagena
Creators: name: Díaz Del Castillo, Edgardo José
name: Pertuz Prieto, Freddy Andrés
Publisher: name: Universidad de Cartagena
Year: 2015
Subjects: Redes

description: Tesis (Ingeniero de Sistemas).--Universidad de Cartagena. Facultad de Ciencias E Ingenierías. Programa de Ingeniería de Sistemas, 2015
description: La presente tesis está orientada a la implementación de una infraestructura de red que soporte servicios webcast para apoyo docente que optimice el aprendizaje de los estudiantes del Programa de Ingenierías de Sistemas a distancia de la Universidad de Cartagena.
On multilevel Monte Carlo methods for deterministic and uncertain hyperbolic systems
Creators: name: Hu, Junpeng
name: Jin, Shi
name: Li, Jinglai
name: Zhang, Lei
Publisher: name: arXiv
Year: 2022
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: In this paper, we evaluate the performance of the multilevel Monte Carlo method (MLMC) for deterministic and uncertain hyperbolic systems, where randomness is introduced either in the modeling parameters or in the approximation algorithms. MLMC is a well known variance reduction method widely used to accelerate Monte Carlo (MC) sampling. However, we demonstrate in this paper that for hyperbolic systems, whether MLMC can achieve a real boost turns out to be delicate. The computational costs of MLMC and MC depend on the interplay among the accuracy (bias) and the computational cost of the numerical method for a single sample, as well as the variances of the sampled MLMC corrections or MC solutions. We characterize three regimes for the MLMC and MC performances using those parameters, and show that MLMC may not accelerate MC and can even have a higher cost when the variances of MC solutions and MLMC corrections are of the same order. Our studies are carried out by a few prototype hyperbolic systems: a linear scalar equation, the Euler and shallow water equations, and a linear relaxation model, the above statements are proved analytically in some cases, and demonstrated numerically for the cases of the stochastic hyperbolic equations driven by white noise parameters and Glimm's random choice method for deterministic hyperbolic equations.
"Comentarios a nuestra legislación penal de menores"
Creators: name: Borge Mendoza, Rafael
Publisher: name: Universidad de Cartagena
Year: 1972
Subjects: Legislación penal - Colombia

description: Tesis (Abogado) -- Universidad de Cartagena. Facultad de Derecho y Ciencias Políticas. Programa de Derecho, 1972
description: La lucha contra la delincuencia juvenil, como política social del estado, en el cual se debe comprender, uno de los capítulos indispensables al estudio y expedición al código del niño, al estilo que se rige hoy en la república oriental.
SU(N) affine Toda solitons and breathers from transparent Dirac potentials
Creators: name: Thies, Michael
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Superconductivity (cond-mat.supr-con)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences

description: Transparent scalar and pseudoscalar potentials in the one-dimensional Dirac equation play an important role as self-consistent mean fields in 1+1 dimensional four-fermion theories (Gross-Neveu, Nambu-Jona Lasinio models) and quasi-one dimensional superconductors (Bogoliubov-De Gennes equation). Here, we show that they also serve as seed to generate a large class of classical multi-soliton and multi-breather solutions of su(N) affine Toda field theories, including the Lax representation and the corresponding vector. This generalizes previous findings about the relationship between real kinks in the Gross-Neveu model and classical solitons of the sinh-Gordon equation to complex twisted kinks.
description: 10 pages, 1 figure; v2: several improvements, matches version accepted for publication by JPhysA
Practice And Challenges Of Succession Planning At Ethiopian Shipping And Logistics Services Enterprise
Creators: name: Hailu, Eyobed
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2018

description: The study aimed at assessing succession planning practices and challenges at Ethiopian Shipping and Logistics Services Enterprise. Specifically, the study aimed in finding answers to four objectives. It assessed the practice of succession planning it also examined the challenges facing human resources succession planning in the enterprise. Furthermore, the study assessed the factors influencing human resources succession planning in the enterprise. Finally, the study looked at strategies used for enhancing the application of human resource succession planning in Ethiopian Shipping and Logistics Services Enterprise. The study employed questionnaire and interview for data collection. The data were analyzed using descriptive statistics such as percentages, mean and standard deviation. The study findings indicate that majority of the respondents have knowledge on the concept of human resource succession planning. The study finding also showed that the enterprise did not properly practice the enable factors of human resource succession planning such as ability to motivate and retain key employees, focusing on roles and responsibilities across a carrier plan and Lack of Plenty of information about employees. Moreover, the enterprise did not properly use various strategies of enhancing human resources succession which included attracting and recruiting potential employees, effective leadership and management development and improving budget. Furthermore, the study recommended that the enterprise should properly implement the positive or success factors of succession planning such as attracting and recruiting the potential employees, rewarding and recognizing hard working employees, effective management and performance Management system.
title: Football and finance: essays on the impact of regulation, governance strategies and covid-19
Creators: name: Alabi, Mobolaji Oluwafisayo
Publisher: name: University of Reading
Year: 2025

description: Football is the most popular sport globally, with audiences worldwide. European football has experienced tremendous growth in the past thirty years and is not just a source of entertainment but a vital contributor to countries' economies as an industry. While the literature is growing with insights into various aspects of the game and business, some gaps exist. This thesis contributes to the literature with three essays on regulation, governance strategies and covid�19. The first paper provides evidence of the impact of UEFA’s financial fair play (FFP) regulation on clubs' financial performance. We use panel data from 37 clubs and the difference-in�differences model to investigate the impact of FFP. The results indicate that while the profitability and indebtedness of clubs exposed to FFP improved, only the improvement in profitability is statistically significant. The result is robust to alternative definitions of exposed clubs and placebo tests. The findings provide evidence for regulators and valuable information to clubs for strategic planning. The second paper contributes to the literature on the relationship between on-field and off-field performances. We use a mixed method case study approach to analyse the competitive and financing strategies and financial management and how they influenced Manchester United and Chelsea’s on-field and off-field performances. The results show that financial regulation, managerial turnover and the role of the sporting director, in addition to the interplay of competitive and financing strategies and financial management, influence on-field and on-field success. The findings provide possible strategies for new and existing club owners. The final paper contributes to the literature on the impact of covid-19 on clubs’ financial performance, using panel data from 36 English clubs. The result suggests that the clubs' profitability, indebtedness and financial stability deteriorated during the pandemic due to lost matchday revenue, though only the deterioration in profitability is statistically significant.
title: Ex vivo activation of naturally occurring IL-17-producing T cells does not require IL-6
Creators: name: Hofstetter, Harald
name: Smolianov, Vsevolod
name: Dehmel, Thomas
name: Kieseier, Bernd C.
name: Hartung, Hans Peter
Publisher: name: German Medical Science GMS Publishing House
Year: 2015
Subjects: subject: 610 Medical sciences; Medicine

description: Interleukin (IL-)17 is a potent proinflammatory cytokine for which an important role in the immune response against infections and in autoimmune diseases has been demonstrated. Recently, it has been shown that - in addition to mature T cells which are primed in the immune periphery - this cytokine can[for full text, please go to the a.m. URL]
description: 60th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN)
Identifying stochastic oscillations in single-cell live imaging time series using Gaussian processes
Creators: name: Phillips, Nick E.
name: Manning, Cerys
name: Papalopulu, Nancy
name: Rattray, Magnus
Publisher: name: arXiv
Year: 2016
Subjects: subject: Quantitative Methods (q-bio.QM)
subject: Molecular Networks (q-bio.MN)
subject: FOS: Biological sciences

description: Multiple biological processes are driven by oscillatory gene expression at different time scales. Pulsatile dynamics are thought to be widespread, and single-cell live imaging of gene expression has lead to a surge of dynamic, possibly oscillatory, data for different gene networks. However, the regulation of gene expression at the level of an individual cell involves reactions between finite numbers of molecules, and this can result in inherent randomness in expression dynamics, which blurs the boundaries between aperiodic fluctuations and noisy oscillators. Thus, there is an acute need for an objective statistical method for classifying whether an experimentally derived noisy time series is periodic. Here we present a new data analysis method that combines mechanistic stochastic modelling with the powerful methods of non-parametric regression with Gaussian processes. Our method can distinguish oscillatory gene expression from random fluctuations of non-oscillatory expression in single-cell time series, despite peak-to-peak variability in period and amplitude of single-cell oscillations. We show that our method outperforms the Lomb-Scargle periodogram in successfully classifying cells as oscillatory or non-oscillatory in data simulated from a simple genetic oscillator model and in experimental data. Analysis of bioluminescent live cell imaging shows a significantly greater number of oscillatory cells when luciferase is driven by a {\it Hes1} promoter (10/19), which has previously been reported to oscillate, than the constitutive MoMuLV 5' LTR (MMLV) promoter (0/25). The method can be applied to data from any gene network to both quantify the proportion of oscillating cells within a population and to measure the period and quality of oscillations. It is publicly available as a MATLAB package.
description: 36 pages, 17 figures
Background Effective Action with Nonlinear Massive Gauge Fixing
Creators: name: Gies, Holger
name: Gkiatas, Dimitrios
name: Zambelli, Luca
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We combine a recent construction of a BRST-invariant, nonlinear massive gauge fixing with the background field formalism. The resulting generating functional preserves background-field invariance as well as BRST invariance of the quantum field manifestly. The construction features BRST-invariant mass parameters for the quantum gauge and ghost fields. The formalism employs a background Nakanishi-Lautrup field which is part of the nonlinear gauge-fixing sector and thus should not affect observables. We verify this expectation by computing the one-loop effective action and the corresponding beta function of the gauge coupling as an example. The corresponding Schwinger functional generating connected correlation functions acquires additional one-particle reducible terms that vanish on shell. We also study off-shell one-loop contributions in order to explore the consequences of a nonlinear gauge fixing scheme involving a background Nakanishi-Lautrup field. As an application, we show that our formalism straightforwardly accommodates nonperturbative information about propagators in the Landau gauge in the form of the so-called decoupling solution. Using this nonperturbative input, we find evidence for the formation of a gluon condensate for sufficiently large coupling, whose scale is set by the BRST-invariant gluon mass parameter.
description: 24 pages, 3 figures
All single-copy ortholog genes of Megalurothrips usitatus
Creators: name: Ma, Ling
name: Liu, Qiaoqiao
name: Wei, Shujun
name: Liu, Shanlin
name: Tian, Li
name: Song, Fan
name: Duan, Yuange
name: Cai, Wanzhi
name: Li, Hu
Publisher: name: figshare
Year: 2023
Subjects: Genomics

description: single-copy orthologous genes of Megalurothrips usitatus
Assessment of the causes of troubled irrigation construction projects (A case of Megech Dam Construction Project)
Creators: name: Yigrem, Alwoye
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2018

description: The purpose of the study was to assess the causes that make irrigation projects in trouble condition by taking the case of Megech Irrigation Dam Construction Project. Despite that the government is committed to develop large scale irrigation projects in different parts of the country, these projects are blamed for their stalling and slippages. The same is true for the ongoing project of Megech Irrigation Dam which is taking longer time. Therefore, this study is conducted to assess the causes related with management mistakes, planning mistakes and external influences that influence the performance of the project. It is a descriptive and explanatory type which employs both qualitative and quantitative approaches. Data is collected from both primary and secondary resources. Questionnaire and semi structured interview was used to collect data from the sample which are selected purposively because of their engagement in this project. The reliability test is done by Cronbach's Alpha test and yields 0.77 which is acceptable. Data analysis is by both qualitative and quantitative approaches in which mean, standard deviation are used for discussion. The findings revealed that the mistakes in the planning stages are significantly affecting the performance of the project. Failure to have a risk management plan, poor management of scope changes, lack of proper financing and forex, political unrest, poor estimation and complexity nature of irrigation projects make the management tough and troubled. Besides, the practice of having prevention strategies is insignificant rather it is intervention approach which is commonly used to recover projects. To alleviate these problems, it is essential to build the capacity of managing projects, involve stakeholders actively, and has a policy to manage risks, deploy effective cost controlling strategies and have public private partnership arrangements.
title: RNAscope: a new method to detect MGMT status?
Creators: name: Kleinlein, Irene
name: Wild, Vanessa
name: Sbiera, Silviu
name: Sbiera, Iuliu
name: Herud, Petra
name: Monoranu, Camelia-Maria
Publisher: name: German Medical Science GMS Publishing House
Year: 2015
Subjects: subject: 610 Medical sciences; Medicine

description: MGMT promoter methylation is a strong prognostic biomarker in glioblastoma patients treated with temozolomide. Methylation-specific PCR and pyrosequencing are the most commonly used DNA-based diagnostic methods for promoter methylation. Both are time- and cost-intensive methods harboring limitations,[for full text, please go to the a.m. URL]
description: 60th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN)
Ultrastrong waveguide QED with giant atoms
Creators: name: Terradas-Briansó, Sergi
name: González-Gutiérrez, Carlos A.
name: Nori, Franco
name: Martín-Moreno, Luis
name: Zueco, David
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum optics with giant emitters has shown a new route for the observation and manipulation of non-Markovian properties in waveguide-QED. In this paper we extend the theory of giant atoms, hitherto restricted to the perturbative light-matter regime, to deal with the ultrastrong coupling regime. Using static and dynamical polaron methods we address the low energy subspace of a giant atom coupled to an Ohmic waveguide beyond the standard rotating wave approximation. We analyze the equilibrium properties of the system by computing the atomic frequency renormalization as a function of the coupling characterizing the localization-delocalization quantum phase transition for a giant atom. We show that virtual photons dressing the ground state are non-exponentially localized around the contact points but decay as a power-law. Dynamics of an initially excited giant atom are studied, pointing out the effects of ultrastrong coupling on the Lamb shift and the spontaneous emission decay rate. Finally we comment on the existence of the so-called oscillating bound states beyond the rotating wave approximation.
description: 12 pages, 6 figures
Change-point detection in high-dimensional covariance structure
Creators: name: Avanesov, Valeriy
name: Buzun, Nazar
Publisher: name: arXiv
Year: 2016
Subjects: subject: Statistics Theory (math.ST)
subject: FOS: Mathematics
subject: 62M10, 62H15 (Primary) 91B84, 62P10 (Secondary)

description: In this paper we introduce a novel approach for an important problem of break detection. Specifically, we are interested in detection of an abrupt change in the covariance structure of a high-dimensional random process -- a problem, which has applications in many areas e.g., neuroimaging and finance. The developed approach is essentially a testing procedure involving a choice of a critical level. To that end a non-standard bootstrap scheme is proposed and theoretically justified under mild assumptions. Theoretical study features a result providing guaranties for break detection. All the theoretical results are established in a high-dimensional setting (dimensionality $p \gg n$). Multiscale nature of the approach allows for a trade-off between sensitivity of break detection and localization. The approach can be naturally employed in an on-line setting. Simulation study demonstrates that the approach matches the nominal level of false alarm probability and exhibits high power, outperforming a recent approach.
description: Acknowledgement correction
Problema social agrario
Creators: name: Meza P., Luis Del C.
Publisher: name: Universidad de Cartagena
Year: 1972
Subjects: Reforma agraria - Colombia

description: Tesis (Abogado) -- Universidad de Cartagena. Facultad de Derecho y Ciencias Políticas. Programa de Derecho, 1972
description: Desequilibrio socio-económico existente en el sector rural, cuando la estructura de la tenencia de la tierra está viciada por defectos que impiden al desarrollo económico o el bienestar social.
Fragment-based lead discovery of novel inhibitors of HIV-1 RT
Creators: name: La, Jennifer
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: The emergence of drug-resistant strains of human immunodeficiency virus (HIV) threatens the efficacy of current therapeutics. Novel drugs are required that are active against these mutants to be successful as a preventative agent and to provide therapeutic options. In this study we have focused on the HIV type 1 (HIV-1) reverse transcriptase (RT) enzyme, which was the first successful anti- acquired immunodeficiency syndrome (AIDS) target. RT remains as relevant as it was 25 years ago, with half of the anti-AIDS drugs approved by the Food and Drug Administration (FDA) being directed at this enzyme in addition to many ongoing studies to identify new RT inhibitors. The purpose of this study was to identify novel inhibitors of HIV-1 RT using a fragment- based drug design approach. The hypothesis was that since HIV RT is a multifunctional enzyme highly dependent on conformational changes for activity, there may be a number of allosteric sites in HIV-1 RT that could be exploited other than those already identified in the literature, and that these sites could be found by probing the HIV-1 RT using fragments. Molecular modelling studies identified 29 novel pockets in HIV-1 RT that could be targeted by small molecule inhibitors. A screen was conducted using a library of fragments and saturation transfer difference (STD) nuclear magnetic resonance (NMR), to identify new binding sites in RT for the design of novel inhibitors, which led to the identification of seven fragment inhibitors of HIV-1 RT. These hits were characterised using an in vitro RT inhibition assay. Steady state kinetic assays showed that two of these fragments, V89 and 2C4, compete with the dNTP substrate and a third, 4A2, competes with DNA substrate. These fragments were tested for inhibitory activity against common drug resistant mutants of HIV-1 RT, K103N, Y181C, G190A as well as against murine moloney leukemia virus (MoMLV) RT and klenow DNA polymerase. In an RNase H activity assay, fragment 4A2 was shown to inhibit RNase H activity of HIV-1 RT. Fragment 4A2 is also an active inhibitor when tested in an anti-HIV assay using TZMbl cells. The fragments identified in this screen were found to possess distinct mechanisms of action from currently available drugs and are promising leads for the development of novel HIV-1 RT inhibitors.
Hydrodynamic charge transport in GaAs/AlGaAs ultrahigh-mobility two-dimensional electron gas
Creators: name: Wang, Xinghao
name: Jia, Peizhe
name: Du, Rui-Rui
name: Pfeiffer, L. N.
name: Baldwin, K. W.
name: West, K. W.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Viscous fluid in an ultrahigh-mobility two-dimensional electron gas (2DEG) in GaAs/AlGaAs quantum wells is systematically studied through measurements of negative magnetoresistance (NMR) and photoresistance under microwave radiation, and the data are analyzed according to recent theoretical work by e.g., Alekseev, Physical Review Letters 117,166601 (2016). Size-dependent and temperature dependent NMR are found to conform to the theoretical predictions. In particular, transport of 2DEG with relatively weak Coulomb interaction (interparticle interaction parameter r_s<1) manifests a crossover between viscous liquid and viscous gas. The size dependence of microwave induced resistance oscillations and that of the '2nd harmonic' peak indicate that 2DEG in a moderate magnetic field should be regarded as viscous fluid as well. Our results suggest that the hydrodynamic effects must be considered in order to understand semiclassical electronic transport in a clean 2DEG.
title: Behandlung mit Neuen oralen Antikoagulantien in Hausarztpraxen
Creators: name: Dinkel, K.
name: Weckbecker, K.
name: Bleckwenn, M.
Publisher: name: German Medical Science GMS Publishing House
Year: 2015
Subjects: subject: Antikoagulation
subject: Hausarztpraxis
subject: NOAK
subject: 610 Medical sciences; Medicine

description: Hintergrund: Mit Einführung der neuen oralen Antikoagulantien (NOAK) stehen für die Prävention von kardioembolischen Komplikationen bei nicht-valvulärem Vorhofflimmern erstmals Alternativen zu den klassischen Vitamin-K-Antagonisten (VKA) zur Verfügung. In der DEGAM-Handlungsempfehlung[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 49. Kongress für Allgemeinmedizin und Familienmedizin
Design, synthesis and pharmacological evaluation of molecular probes targeting the dopamine D2 receptor
Creators: name: Shonberg, Jeremy
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: The dopamine D2 receptor (D2R) is a member of the GPCR superfamily, and is inextricably linked to a number of important disease states, including schizophrenia and Parkinson’s disease. This thesis focuses on the design and synthesis of novel compounds to probe emerging concepts in D2R structure and function, including allosterism, dimerization, biased agonism, bitopic ligands and bivalent ligands. Firstly, a recent report highlighted SB269652 as the first drug-like allosteric antagonist of the D2R. However SB269652 shares structural homology with a number of orthosteric D2R antagonists and partial agonists. To understand this mechanism of action, we designed and synthesized truncated derivatives of SB269652 with the aim of discovering purely allosteric and orthosteric fragments (Chapter 2). Utilizing this approach, we found that SB269652 binds in a bitopic (dual orthosteric/allosteric) mode within one protomer whilst allosterically modulating a second protomer as part of a dimeric (or higher order) complex. Chapter 2 has been submitted for publication in Nature Chemical Biology. In Chapter 3 we explore the current knowledge surrounding the principles of partial and biased agonism at GPCRs. We outline recent challenges and successes, with particular focus on relating ligand structure to function. Chapter 3 forms the basis of a review article planned for submission to the Journal of Medicinal Chemistry, and includes extensive focus on the D2R; a major theme of the thesis. To further our understandings of biased agonism, Chapter 4 focuses on the synthesis of novel D2R ligands able to fine-tune efficacy and biased agonism using subtle structural modifications based on the hit D2R partial agonist, MIPS1026. The findings imply that biased ligands interact with a secondary D2R binding site, and thus potentially represent the first D2R bitopic ligands. Chapter 4 has been prepared for submission to the Journal of Medicinal Chemistry. Finally, Chapter 5 (published as a review; Shonberg, J. et al. ChemMedChem 2011, 6 (6), 963-974.) and Chapter 6 focus on the synthesis of bivalent ligands to explore the structure and function of D2R dimers and higher order oligomeric complexes. In Chapter 6, bivalent ligands were designed based on the aporphine scaffold with variations in linker attachment position and spacer length. We found that at certain lengths, bivalent ligands exhibited full recovery of functional efficacy equivalent to the potent D2R agonist, apomorphine. Chapter 6 has been prepared for submission to ACS Medicinal Chemistry Letters. Overall, this thesis successfully uses novel molecular probes to further our understandings of the D2R structure and function. We show the ability to design D2R biased agonists, allosteric fragments, bitopic ligands, and bivalent ligands with various effects, and diverse implications on the structure and function of the D2R.
Inverse Hamiltonian design by automatic differentiation
Creators: name: Inui, Koji
name: Motome, Yukitoshi
Publisher: name: arXiv
Year: 2022
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: An ultimate goal of materials science is to deliver materials with desired properties at will. In the theoretical study, a standard approach consists of constructing a Hamiltonian based on phenomenology or first principles, calculating physical observables, and improving the Hamiltonian through feedback. However, there is also an approach that bypasses such a cumbersome procedure, namely, to obtain an appropriate Hamiltonian directly from the desired properties. Solving the inverse problem has the potential to reach qualitatively different principles, but most research to date has been limited to quantitative determination of parameters within known models. Here, we present a general framework that enables the inverse design of Hamiltonians by optimizing numerous parameters using automatic differentiation. By applying it to the quantum anomalous Hall effect (AHE), we show that our framework can not only rediscover the Haldane model but also automatically generate a new Hamiltonian that exhibits a six-times larger AHE. In addition, the application to the photovoltaic effect (PVE) gives an optimal Hamiltonian for electrons moving on a noncoplanar spin texture, which can generate $\sim 900$~A/m$^2$ under solar radiation. This framework would accelerate materials exploration by establishing unprecedented models and principles beyond human intuition and empirical rules.
title: German Climate Observing Systems. Inventory report on the Global Climate Observing System (GCOS)
Creators: name: Deutscher Wetterdienst
Publisher: name: Deutscher Wetterdienst
Year: 2017

description: Comprehensive information is the basis of every decision in politics and business. Knowledge about the state of the climate system in the past, present and future plays an important role.

For the first time, this report provides an almost complete overview of the services and programmes currently in operation in Germany to survey the climate variables that are essential for our country.
$μ$Puppet: A Declarative Subset of the Puppet Configuration Language
Creators: name: Fu, Weili
name: Perera, Roly
name: Anderson, Paul
name: Cheney, James
Publisher: name: arXiv
Year: 2016
Subjects: subject: Programming Languages (cs.PL)
subject: FOS: Computer and information sciences

description: Puppet is a popular declarative framework for specifying and managing complex system configurations. The Puppet framework includes a domain-specific language with several advanced features inspired by object-oriented programming, including user-defined resource types, 'classes' with a form of inheritance, and dependency management. Like most real-world languages, the language has evolved in an ad hoc fashion, resulting in a design with numerous features, some of which are complex, hard to understand, and difficult to use correctly. We present an operational semantics for $μ$Puppet, a representative subset of the Puppet language that covers the distinctive features of Puppet, while excluding features that are either deprecated or work-in-progress. Formalising the semantics sheds light on difficult parts of the language, identifies opportunities for future improvements, and provides a foundation for future analysis or debugging techniques, such as static typechecking or provenance tracking. Our semantics leads straightforwardly to a reference implementation in Haskell. We also discuss some of Puppet's idiosyncrasies, particularly its handling of classes and scope, and present an initial corpus of test cases supported by our formal semantics.
description: Full version of ECOOP 2017 conference paper
Drivers of Employee Engagement: The Case of Ethiopian Insurance Corporation
Creators: name: Tezera, Masresha
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2018

description: This paper is intended to determine the drivers of employee engagement in the case of Ethiopian Insurance Corporation. In order to identify whether the drivers considered as having an impact on the engagement of employees, it is necessary to examine the engagement level using the appropriate measurement tool and then establish the relationship between the drivers and the engagement level. In view of this, the researcher employed a validated engagement measurement tool known as the Utrecht Work Engagement Scale (UWES). Data were collected by distributing questionnaires to 230 employees of EIC. Respondents were requested to mark their agreement level which is based on 5-point Likert Scale. The question related to engagement consists of the factors that are supposed to drive engagement: a) Training, Development and Career Opportunity b) Immediate Management c) Performance and Appraisal d) Equal Opportunity and Fair treatment, e) Nature of the job. The engagement measurement criteria designed by Schaufeli& Baker (2004) which has three aspects namely, vigour, dedication and absorption which in total consist 17 items were measured. The data gathered was entered into SPSS in order to analyse by the statistical tools such as descriptive statistics which involves percentage analysis, mean analysis and correlation of independent and dependent variables. The findings indicated that the mean value of all engagement dimensions i.e. Vigour, Dedication and Absorption is above average and the aggregate mean value of engagement is 3.49 which are moderately engaged. Furthermore, the result of engagement drivers shows that the management of EIC need to address issues related to training, development and career opportunity as well as performance management and appraisal as employees rating is well below the acceptable range. If the factors that affect engagement level are addressed there will be an improvement in the engagement level of employees since the regression analysis result indicate R Square value of .77 and P<.001. This means that 77% of variance in employee engagement level is explained by the engagement factors and the 23% is attributed to other factors. Therefore, there is a strong relationship between the independent variables and the dependent variables that the factors identified as drivers of employee engagement need to be addressed well in order to improve employee engagement
Characterisation of GABAergic neurons derived from mouse embryonic stem cells
Creators: name: Khaira, Simer Kaur
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Mouse embryonic stem (mES) cells possess a virtually unlimited differentiation potential and have been utilised to generate a variety of different cell types. A great deal of stem cell research focuses on the enrichment of differentiated cultures with a desired cell type. However, differentiation protocols rarely result in homogeneous populations of cells. Generally, embryonic stem cells will differentiate into neural progenitors by default, often giving rise to GABAergic neurons; GABA (γ-aminobutyric acid) is the main inhibitory neurotransmitter in the brain. In this thesis, I investigate some of the physiological properties of GABAergic neurons differentiated from mouse embryonic stem cells. Nearly all mES cell derived neurons derived using a forebrain differentiation protocol responded to the addition of the common neurotransmitters ATP, noradrenaline, acetylcholine and glutamate with elevations of intracellular calcium (Chapter 3). Purinergic receptors have been shown to play a role in modulating GABAergic neuron behaviour in vitro via the P2X2, P2X4 and P2X7 receptor subtypes (Amadio et al., 2007; Papp et al., 2004). The exact subtype(s) of purinergic receptor present on these cultured GABAergic neurons was examined using a variety of agonists and antagonists, as well as pH and Zinc (Chapter 4). The majority of these purinergic receptors were shown to be P2X2, P2X4 and P2Y1. Although reverse transcriptase PCR indicated the presence of other receptor subtypes in culture, the location(s) of these receptors were not pharmacologically characterised. Altering the timing of growth factor addition drove cells towards a midbrain, rather than forebrain, phenotype and the resultant GABAergic neurons responded differently to stimulation with neurotransmitters, particularly dopamine. The dopamine receptor subtype(s) involved in this response were investigated further (Chapter 5). In addition, classification of the types of GABAergic neurons present in cultures was attempted by examining the presence of calcium binding proteins and neuropeptides in culture. Forebrain and midbrain phenotypes were immunoreactive for Neuropeptide Y, however only neurons directed towards a midbrain phenotype displayed co-localisation with cholecystokinin. The role of genes, particularly Math1, Ptf1a and Pitx2, previously associated with GABAergic, or neuronal, differentiation was investigated using lentiviral transduction (Chapter 6). Mis-expression of these genes did not alter the GABAergic neuronal yield, however Math1 transduced mES cells generated more neurons. An siRNA-mediated reduction in Pitx2 gene expression during differentiation did not affect the ability of the cultures to generate GABAergic neurons, but the pharmacological properties of resultant neurons was altered. Cells transfected with Pitx2 siRNA had reduced responses to noradrenaline, acetylcholine and dopamine.
Semi-Supervised Subspace Clustering via Tensor Low-Rank Representation
Creators: name: Jia, Yuheng
name: Lu, Guanxing
name: Liu, Hui
name: Hou, Junhui
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: In this letter, we propose a novel semi-supervised subspace clustering method, which is able to simultaneously augment the initial supervisory information and construct a discriminative affinity matrix. By representing the limited amount of supervisory information as a pairwise constraint matrix, we observe that the ideal affinity matrix for clustering shares the same low-rank structure as the ideal pairwise constraint matrix. Thus, we stack the two matrices into a 3-D tensor, where a global low-rank constraint is imposed to promote the affinity matrix construction and augment the initial pairwise constraints synchronously. Besides, we use the local geometry structure of input samples to complement the global low-rank prior to achieve better affinity matrix learning. The proposed model is formulated as a Laplacian graph regularized convex low-rank tensor representation problem, which is further solved with an alternative iterative algorithm. In addition, we propose to refine the affinity matrix with the augmented pairwise constraints. Comprehensive experimental results on eight commonly-used benchmark datasets demonstrate the superiority of our method over state-of-the-art methods. The code is publicly available at https://github.com/GuanxingLu/Subspace-Clustering.
title: Biomarker selection for M1- and M2-polarized canine microglia/macrophages
Creators: name: Heinrich, Franziska
name: Spitzbarth, Ingo
name: Kalkuhl, Arno
name: Deschl, Ulrich
name: Baumgärtner, Wolfgang
name: Ulrich, Reiner
Publisher: name: German Medical Science GMS Publishing House
Year: 2015
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: Microglia/Macrophages (M/M) are a heterogeneous cell population involved in tissue homeostasis, inflammation and immunity of the central nervous system. Depending on the micromilieu, M/M exhibit different pro- (M1) and anti-inflammatory (M2) phenotypes. Currently, dogs are[for full text, please go to the a.m. URL]
description: 60th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN)
1573 single copy genes kept after trimming alignment, and SRH testing
Creators: name: Ma, Ling
name: Liu, Qiaoqiao
name: Wei, Shujun
name: Liu, Shanlin
name: Tian, Li
name: Song, Fan
name: Duan, Yuange
name: Cai, Wanzhi
name: Li, Hu
Publisher: name: figshare
Year: 2023
Subjects: Genomics

description: 1573 single copy genes kept after trimming alignment, and SRH testing
Estudio de factibilidad para el diseño de un sistema de reutilizacion de aguas grises
Creators: name: Barros Ruiz, Ana Milena
name: Lecompte Baena, Ivan Mauricio
Publisher: name: Universidad de Cartagena
Year: 2005
Subjects: Ingeniería sanitaria
Agua

description: Tesis (Ingeniero Civil).--Universidad de Cartagena. Facultad de Ciencias E Ingenierías. Programa de Ingeniería Civil, 2005.
description: El presente estudio tiene por objeto realizar un estudio de factibilidad para el diseño de un sistema de reutilizacion de aguas grises.
Development of novel kv1.3 ion channel blockers based upon diphenoxylate
Creators: name: Nguyen, William
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Psoriasis is an autoimmune disorder of the skin that affects millions of people worldwide. Current treatments have limitations concerning their efficacy, side effect profiles and cost. The need for better treatments is clear and our research is aimed at developing a novel therapy for psoriasis with an improved profile. Previous research has shown that a drug normally used for diarrhoea (diphenoxylate) was able to treat psoriasis; however this important observation was not fully evaluated. Our preliminary work has demonstrated that diphenoxylate blocks a key potassium channel (Kv1.3) associated with the immune system. Indeed, Kv1.3 channels have been shown to have a role in autoimmune disorders such as psoriasis and may explain the observations that diphenoxylate was able to treat psoriasis. Our initial research has generated novel analogues of diphenoxylate to explore the SAR of this molecule at Kv1.3 channels. Further synthetic work has built on this initial SAR to generate compounds that are over 100 times more potent at Kv1.3 channels than our original lead, diphenoxylate. In addition these potent Kv1.3 blockers are lower in molecular weight and have reduced lipophilicity While providing a potential explanation for the observation that diphenoxylate alleviates psoriasis symptoms, many new chemotypes were also produced that block Kv1.3 channels. A selected number of these interesting leads will be progressed into functional assays to further assess their immunomodulatory activity. Ultimately, this work has provided new opportunities for the development of novel treatments that target autoimmune disorders.
title: Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A
Creators: name: Stassart, Ruth
name: Fledrich, Robert
name: Abdelaal, Tamer
name: Brück, Wolfgang
name: Nave, Klaus-Armin
name: Sereda, Michael
Publisher: name: German Medical Science GMS Publishing House
Year: 2015
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: A progressive loss of axons determines the clinical phenotype of chronic demyelinating peripheral neuropathies, such as the incurable Charcot Marie Tooth disease type 1A (CMT1A). Even though most affected patients only seek medical advice in young adulthood, a moderate walking disability[for full text, please go to the a.m. URL]
description: 60th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN)
Aspects of Superdeterminism Made Intuitive
Creators: name: Nikolaev, Vitaly
name: Vervoort, Louis
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: History and Philosophy of Physics (physics.hist-ph)
subject: FOS: Physical sciences

description: We attempt to make superdeterminism more intuitive, notably by simulating a deterministic model system, a billiard game. In this system an initial 'bang' correlates all events, just as in the superdeterministic universe. We introduce the notions of 'strong' and 'soft' superdeterminism, in order to clarify debates in the literature. Based on the analogy with billiards, we show that superdeterministic correlations may exist as a matter of principle, but be undetectable for all practical purposes. This allows us to counter classical objections to superdeterminism such as the claim that it would be at odds with the scientific method, and with the construction of new theories. Finally, we show that probability theory, as a physical theory, indicates that superdeterminism has a greater explanatory power than its competitors: it can coherently answer questions for which other positions remain powerless.
description: Paper presented at the conference "Superdeterminism and Retrocausality", Bonn, May 17-20, 2022, cf. https://superdetermined.org/
title: Multinodular and vacuolating neuronal tumor of the cerebrum
Creators: name: Niehusmann, Pitt
name: Greschus, Susanne
name: Hattingen, Elke
name: Grote, Alexander
name: Meinhardt, Matthias
name: Surges, Rainer
name: Kuchelmeister, Klaus
Publisher: name: German Medical Science GMS Publishing House
Year: 2015
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: Multinodular and vacuolating neuronal tumor of the cerebrum (MVNT) was first described in 2013. To date, only three reports with 13 cases of MVNT have been published. Objectives: To report on our single institute diagnostic experience with this newly described tumor entity. Patients[for full text, please go to the a.m. URL]
description: 60th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN)