cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Garcinia harmandii Pierre 1882
Creators: name: Nazre, M.
name: Newman, M. F.
name: Pennington, R. T.
name: Middleton, D. J.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Malpighiales
Clusiaceae
Garcinia
Garcinia harmandii

description: 6. Garcinia harmandii Pierre (1882: ad pl. 60).
 Lectotype (designated here):— CAMBODIA, Kampong Thom, Compong Soai, February 1876, Harmand 349 (P!). [Figure 11].
 Small bushy tree, 6–10 m tall. Bole: no information. Exudate yellow. Twigs round and slightly angled, wrinkled longitudinally when dry, pale grey-brown to yellowish or blackish. Petiole dark brown or blackish, very finely transversely striate and slightly keeled, stout and short, 0.2–0.9 cm long. Lamina leathery, grey-brown or dark brown, spathulate or obovate, occasionally elliptic, 3.5–9.2 × 1.3–3.6 cm, apex sharply acuminate to mucronate, base cuneate to acute; margin entire and finely revolute; midrib flattened or slightly sunken above, raised below; secondary veins visible and slightly raised on both surfaces, cladodromous with intra-marginal veins; tertiary veins inconspicuous and fine, weakly and transversely ramified and reticulate. Glands very fine, inconspicuous to nearly invisible below, invisible above, in short wavy lines running across secondary veins. Inflorescences terminal; 2–6 flowers in a cluster, usually triads in males; sepals and petals 4; bracts triangular to 2 mm long. Male flowers [in bud] 3(–6); nearly sessile or on a very short pedicel; sepals concave, orbiculate or obovate, coriaceous, to 4 mm long; petals elliptic to oblong, to 8 mm long; stamens 4-lobed, opposite petals; pistillodes fungiform. Female flowers solitary or in a triad, pedicel short to 3 mm long; bracteole present; sepals concave, orbiculate, to 3.5 mm long; petals ovate, to 4 mm long; ovary sub-globose tipped with a black, rugose stigma. Fruits small, globose or ovoid, 7–10 × 6–11 mm, turning purplish when mature, wall rough and wrinkled when dry; tipped with sessile, black rugose, discoid or skull-cap-like stigma; seeds with a white, sweet aril.
 Distribution and Habitat:—Lowland and hill forest in Cambodia and Vietnam.
 Taxonomic Notes:—Little information is available for this species which is poorly represented in herbaria. The species is characterised by a spathulate leaf with a short pointed apex.
 Additional specimens examined:— CAMBODIA: Mekong, 1866, Thorel 1018 (K!); Samrong Tong, Sruoi, March 1870, Pierre 776 (K!, P!); Kompong Speu, 1 June 1930, Poilane 17388 (P!).
 VIETNAM: Dong Nai: April 1873, Pierre 1371 (A!, K!).
description: Published as part of Nazre, M., Newman, M. F., Pennington, R. T. & Middleton, D. J., 2018, Taxonomic Revision of Garcinia Section Garcinia (Clusiaceae), pp. 1-52 in Phytotaxa 373 (1) on page 29, DOI: 10.11646/phytotaxa.373.1.1, http://zenodo.org/record/13727567
Evolution of low-frequency contribution in emission of steep-spectrum radio sources
Creators: name: Miroshnichenko, Alla
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We consider evolution properties of galaxies and quasars with steep radio spectrum at the decametre band from the UTR-2 catalogue. The ratios of source's monochromatic luminosities at the decametre and high-frequency bands display the dependence on the redshift, linear size, characteristic age of examined objects. At that, the mean values of corresponding ratios for considered galaxies and quasars have enough close quantities, testifying on the unified model of sources. We analyse obtained relations for two types of steep-spectrum sources (with linear steep spectrum (S) and low-frequency steepness after a break (C+)) from the UTR-2 catalogue.
description: to Proceedings of IAU Symposium No.308
Chimeric Antigen Receptor T Cell Bearing Herpes Virus Entry Mediator Co-stimulatory Signal Domain Exhibits High Functional Potency
Creators: name: Ye, Chaobaihui
name: Nunoya, Jun-ichi
name: Su, Lishan
name: Masuda, Michiaki
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2019

description: Chimeric antigen receptor (CAR) is a hybrid molecule consisting of an antigen-binding domain and a signal transduction domain. The artificial T cells expressing CAR (CAR-T cells) are expected to be a useful tool for treatment of various diseases, such as cancer. The addition of a co-stimulatory signal domain (CSSD) to CAR is shown to be critical for modulating CAR-T cell activities. However, the interplay among types of CSSDs, effector functions, and characteristics of CAR-T cells is largely unknown. To elucidate the interplay, we analyzed effector functions, differentiation to memory T cell subsets, exhaustion, and energy metabolism of the CAR-T cells with different CSSDs. Comparing to the CAR-T cells bearing a CD28- or 4-1BB-derived CSSD, which are currently used for CAR-T cell development, we found that the CAR-T cells with a herpes virus entry mediator (HVEM)-derived CSSD exhibited enhanced effector functions and efficient and balanced differentiation to both central and effector memory subsets, associated with an elevated energy metabolism and a reduced level of exhaustion. Thus, we developed the CAR-T cells bearing the CSSD derived from HVEM with high functional potency. The HVEM-derived CSSD may be useful for developing effective CAR-T cells.
Low-energy Coulomb excitation of $^{62}$Fe and $^{62}$Mn following in-beam decay of $^{62}$Mn
Creators: name: Gaffney, L. P.
name: Van de Walle, J.
name: Bastin, B.
name: Bildstein, V.
name: Blazhev, A.
name: Bree, N.
name: Cederkäll, J.
name: Darby, I.
name: De Witte, H.
name: DiJulio, D.
name: Diriken, J.
name: Fedosseev, V. N.
name: Fransen, Ch.
name: Gernhäuser, R.
name: Gustafsson, A.
name: Hess, H.
name: Huyse, M.
name: Kesteloot, N.
name: Kröll, Th.
name: Lutter, R.
name: Marsh, B. A.
name: Reiter, P.
name: Seidlitz, M.
name: Van Duppen, P.
name: Voulot, D.
name: Warr, N.
name: Wenander, F.
name: Wimmer, K.
name: Wrzosek-Lipska, K.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Sub-barrier Coulomb-excitation was performed on a mixed beam of $^{62}$Mn and $^{62}$Fe, following in-trap $β^{-}$ decay of $^{62}$Mn at REX-ISOLDE, CERN. The trapping and charge breeding times were varied in order to alter the composition of the beam, which was measured by means of an ionisation chamber at the zero-angle position of the Miniball array. A new transition was observed at 418~keV, which has been tentatively associated to a $(2^{+},3^{+})\rightarrow1^{+}_{g.s.}$ transition. This fixes the relative positions of the $β$-decaying $4^{+}$ and $1^{+}$ states in $^{62}$Mn for the first time. Population of the $2^{+}_{1}$ state was observed in $^{62}$Fe and the cross-section determined by normalisation to the $^{109}$Ag target excitation, confirming the $B(E2)$ value measured in recoil-distance lifetime experiments.
description: 9 pages, 10 figures
Specific activation in vivo of HIV-1 by a bromodomain inhibitor from monocytic cells in humanized mice under antiretroviral therapy
Creators: name: Cheng, Liang
name: Ma, Jianping
name: Reszka-Blanco, Natalia
name: Li, Guangming
name: Chi, Liqun
name: Su, Lishan
name: Li, Feng
name: Jeffrey, Jerry
name: Zhang, Zheng
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2019

description: Combination antiretroviral therapy (cART) effectively suppresses HIV-1 replication and enables HIV-infected individuals to live long, productive lives. However, the persistence of HIV-1 reservoirs of both T and myeloid cells with latent or low-replicating HIV-1 in patients under cART makes HIV-1 infection an incurable disease. Recent studies have focused on the development of strategies to activate and purge these reservoirs. Bromodomain and extraterminal domain proteins (BETs) are epigenetic readers involved in modulating gene expression. Several bromodomain inhibitors (BETi) are reported to activate viral transcription in vitro in HIV-1 latency cell lines in a P-TEFb (CDK9/cyclin T1)-dependent manner. Little is known about BETi efficacy in activating HIV-1 reservoir cells under cART in vivo. Here we report that a BETi (I-BET151) efficiently activated HIV-1 reservoirs under effective cART in humanized mice in vivo. Interestingly, I-BET151 during suppressive cART in vivo activated HIV-1 gene expression only in monocytic cells and not in CD4 T cells. We further demonstrate that BETi preferentially enhanced HIV-1 gene expression in monocytic cells rather than in T cells and that whereas CDK9 was involved in activating HIV-1 by I-BET151 in both monocytic and T cells, CDK2 enhanced HIV-1 transcription in monocytic cells but inhibited it in T cells. Our findings reveal a role for CDK2 in differential modulation of HIV-1 gene expression in myeloid cells and in T cells and provide a novel strategy to reactivate monocytic reservoirs with BETi during cART. IMPORTANCE Bromodomain inhibitors have been reported to activate HIV-1 transcription in vitro, but their effect on activation of HIV-1 reservoirs during cART in vivo is unclear. We found that BETi (I-BET151) treatment reactivated HIV-1 gene expression in humanized mice during suppressive cART. Interestingly, I-BET151 preferentially reactivated HIV-1 gene expression in monocytic cells, but not in CD4 T cells, in cART-treated mice. Furthermore, I-BET151 significantly increased HIV-1 transcription in monocytic cells, but not in HIV-1-infected CD4 T cells, via CDK2-dependent mechanisms. Our findings suggest that BETi can preferentially activate monocytic HIV-1 reservoir cells and that a combination of reservoir activation agents targeting different cell types and pathways is needed to achieve reactivation of different HIV-1 reservoir cells during cART.
Supplementary Information from A cultural evolutionary theory that explains both gradual and punctuated change
Creators: name: Vidiella, Blai
name: Carrignon, Simon
name: Alexander Bentley, R.
name: O’Brien, Michael J.
name: Valverde, Sergi
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Environmental Science

description: Cumulative cultural evolution (CCE) occurs among humans who may be presented with many similar options from which to choose, as well as many social influences and diverse environments. It is unknown what general principles underlie the wide range of CCE dynamics and whether they can all be explained by the same unified paradigm. Here, we present a scalable evolutionary model of discrete choice with social learning, based on a few behavioural science assumptions. This paradigm connects the degree of transparency in social learning to the human tendency to imitate others. Computer simulations and quantitative analysis show the interaction of three primary factors—information transparency, popularity bias and population size—drives the pace of CCE. The model predicts a stable rate of evolutionary change for modest degrees of popularity bias. As popularity bias grows, the transition from gradual to punctuated change occurs, with maladaptive sub-populations arising on their own. When the popularity bias gets too severe, CCE stops. This provides a consistent framework for explaining the rich and complex adaptive dynamics taking place in the real-world, such as modern digital media.
Garcinia ochracea Nazre 2018, sp. nov.
Creators: name: Nazre, M.
name: Newman, M. F.
name: Pennington, R. T.
name: Middleton, D. J.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Malpighiales
Clusiaceae
Garcinia
Garcinia ochracea

description: 9. Garcinia ochracea Nazre, sp. nov.
Garciniae diospyrifoliae similis sed stigmate in fructu complanato haud lobato differt.
 Type:— PAPUA NEW GUINEA, Amanab West Sepik, 25 November 1971, Streimann & Martin LAE 52886 (Holotype: E!). [Figure 16].
 Small tree to 6 m tall, slender. Bole: no information. Exudate: no information. Twigs slender, round to angled, longitudinally striate when dry; reddish brown or brownish yellow. Petiole finely transversely striate, darker colour than twigs, 0.5–0.75 cm long. Lamina thinly leathery, pale grey-brown or brownish to yellowish, darker and shiny above, slightly glaucous or opaque yellowish below, elliptic, 6–9.5 × 2.1–5.3 cm, apex acute and blunt, sometimes blunt-acuminate, base acute to cuneate; midrib yellowish, raised above, flattened or weakly raised below; margin entire and finely revolute; secondary veins inconspicuous on both sides, fine, brochidodromous, closely arranged; tertiary veins invisible. Glands faint to invisible, fine, closely arranged in dark grey-black, interrupted, wavy lines, running across the secondary veins, nearly parallel to midrib. Inflorescences terminal, 1–2-flowered, female flowers always solitary; bracts not found. Male flowers with 4 sepals and petals, leathery, outer usually thicker; pedicel 6 mm long; sepals ovate or orbiculate, to 6 mm across; petals red turning maroon when dry, oblanceolate or obovate, to 10 mm long; stamens yellow, in a mass, weakly 4-lobed, central bundle surrounding the pistillode; pistillode fungiform; anthers 2-thecous with a short filament. Female flowers not seen. Fruit globose, cream turning red, reddish or maroonbrown to brownish when dry, wall smooth, 1.8–2.3 × 1.8–2.1 cm, tipped with a black stigma, sessile, flattened on the surface but slightly sunken in the middle, margin weakly crenate, to 7 mm across; with thick leathery prominent sepals; seed unknown.
 Distribution and Habitat:—Lowland forest in New Guinea, endemic.
 Taxonomic Notes:—The fruits resemble G. diospyrifolia and G. nitida but the stigma is rather flat and without lobes. There are also vegetative characters that can differentiate the species: the leaf with faint and nearly invisible venation on the lower surface, and the glandular lines almost invisible.
 Additional specimen examined:— PAPUA NEW GUINEA: West Sepik: Amanab, Imonda Patrol post, 25 November 1971, Streimann & Martin LAE52890 (E!).
description: Published as part of Nazre, M., Newman, M. F., Pennington, R. T. & Middleton, D. J., 2018, Taxonomic Revision of Garcinia Section Garcinia (Clusiaceae), pp. 1-52 in Phytotaxa 373 (1) on page 37, DOI: 10.11646/phytotaxa.373.1.1, http://zenodo.org/record/13727567
Disruption of HBx-DDB1 by NTZ: New Mechanistic Insight Into an Old Drug With Broad Anti-infective Activities
Creators: name: Su, Lishan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2019

description: Hepatitis B virus (HBV) infection leads to chronic
hepatitis B (CHB) in approximately 250 million
people worldwide, putting them at high risk for developing
cirrhosis and hepatocellular carcinoma. HBV is a partially
double-stranded DNA virus that belongs to the Hepadnaviridae
family. After entry into host cells, the viral genome is
transported into the nucleus and converted to a covalently
closed circular DNA (cccDNA), which serves as the template
for all HBV viral RNAs. Currently available HBV
antiviral drugs inhibit the reverse transcription of HBV
pregenomic RNA but fail to suppress the established
cccDNA reservoir in infected hepatocytes, resulting in viral
rebound after therapy. In addition, HBV surface antigen
hepatitis B surface antigen expressed from the cccDNA
maintains immune tolerance to prevent induction of antibodies
to hepatitis B surface antigen, which are critical for
a functional cure of CHB in patients.
Edge conflicts do not determine geodesics in the associahedron
Creators: name: Cleary, Sean
name: Maio, Roland
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: There are no known efficient algorithms to calculate distance in the one-skeleta of associahedra, a problem that is equivalent to finding rotation distance between rooted binary trees or the flip distance between polygonal triangulations. One measure of the difference between trees is the number of conflicting edge pairs, and a natural way of trying to find short paths is to minimize successively this number of conflicting edge pairs using flip operations in the corresponding triangulations. We describe examples that show that the number of such conflicts does not always decrease along geodesics. Thus, a greedy algorithm that always chooses a transformation that reduces conflicts will not produce a geodesic in all cases. Further, for any specified amount, there are examples of pairs of all large sizes showing that the number of conflicts can increase by that amount along any geodesic between the pairs.
description: 18 pages, 8 figures. We are grateful to anonymous reviewers for suggestions leading to multiple significant improvements
Regulatory NK cells mediated between immunosuppressive monocytes and dysfunctional T cells in chronic HBV infection
Creators: name: Zhai, Naicui
name: Cui, An
name: Wang, Guangyi
name: Niu, Junqi
name: Li, Haijun
name: Song, Hongxiao
name: Su, Lishan
name: Tu, Zhengkun
name: Wang, Zhongfeng
name: Yang, Yang
name: Crispe, Ian Nicholas
name: Li, Tiangyang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: Background and aims HBV infection represents a major health problem worldwide, but the immunological mechanisms by which HBV causes chronic persistent infection remain only partly understood. Recently, cell subsets with suppressive features have been recognised among monocytes and natural killer (NK) cells. Here we examine the effects of HBV on monocytes and NK cells. Methods Monocytes and NK cells derived from chronic HBV-infected patients and healthy controls were purified and characterised for phenotype, gene expression and cytokines secretion by flow cytometry, quantitative real-time (qRT)-PCR, ELISA and western blotting. Culture and coculture of monocytes and NK cells were used to determine NK cell activation, using intracellular cytokines staining. Results In chronic HBV infection, monocytes express higher levels of PD-L1, HLA-E, interleukin (IL)-10 and TGF-β, and NK cells express higher levels of PD-1, CD94 and IL-10, compared with healthy individuals. HBV employs hepatitis B surface antigen (HBsAg) to induce suppressive monocytes with HLA-E, PD-L1, IL-10 and TGF-β expression via the MyD88/NFκ B signalling pathway. HBV-treated monocytes induce NK cells to produce IL-10, via PD-L1 and HLA-E signals. Such NK cells inhibit autologous T cell activation. Conclusions Our findings reveal an immunosuppressive cascade, in which HBV generates suppressive monocytes, which initiate regulatory NK cells differentiation resulting in T cell inhibition.
AI and IoT in managing geriatric care facilities
Creators: name: HS, Surya
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 429999
subject: Other health sciences not elsewhere classified

description: As global populations age rapidly, the need for efficient and compassionate elderly care becomes increasingly critical. Geriatric care facilities are facing mounting challenges in delivering personalized, timely, and quality healthcare to older adults, many of whom suffer from multiple chronic conditions and cognitive decline. The integration of Artificial Intelligence (AI) and the Internet of Things (IoT) in managing these facilities is revolutionizing the way eldercare is administered. This paper explores the technological underpinnings, applications, and benefits of AI and IoT in geriatric settings, from remote health monitoring and predictive analytics to intelligent environmental control and cognitive support. It also addresses implementation challenges, ethical concerns, and the potential for future innovation in enhancing the quality of life for older adults.
An Origin for Multi-Phase Gas in Galactic Winds and Halos
Creators: name: Thompson, Todd A.
name: Quataert, Eliot
name: Zhang, Dong
name: Weinberg, David
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The physical origin of high velocity cool gas seen in galactic winds remains unknown. Following Wang (1995), we argue that radiative cooling in initially hot thermally-driven outflows can produce fast neutral atomic and photoionized cool gas. The inevitability of adiabatic cooling from the flow's initial 10^7-10^8K temperature and the shape of the cooling function for T<10^7K imply that outflows with hot gas mass-loss rate relative to star formation rate of beta=Mdot_hot/Mdot_star > 0.5 cool radiatively on scales ranging from the size of the energy injection region to tens of kpc. We highlight the beta and star formation rate surface density dependence of the column density, emission measure, radiative efficiency, and velocity. At r_cool, the gas produces X-ray and then UV/optical line emission with a total power bounded by 10^{-2} L_star if the flow is powered by steady-state star formation with luminosity L_star. The wind is thermally unstable at r_cool, potentially leading to a multi-phase medium. Cooled winds decelerate significantly in the extended gravitational potential of galaxies. The cool gas precipitated from hot outflows may explain its prevalence in galactic halos. We forward a picture of winds whereby cool clouds are initially accelerated by the ram pressure of the hot flow, but are rapidly shredded by hydrodynamical instabilities, thereby increasing beta, seeding radiative and thermal instability, and cool gas rebirth. If the cooled wind shocks as it sweeps up the circumgalactic medium, its cooling time is short, thus depositing cool gas far out into the halo. Finally, conduction can dominate energy transport in low-beta hot winds, leading to flatter temperature profiles than otherwise expected, potentially consistent with X-ray observations of some starbursts.
description: 15 pages, 5 figures. Accepted to MNRAS
A novel hybrid data mining approach for knowledge extraction and classification in medical databases
Creators: name: Hassan, Syed Zahid
Publisher: name: CQUniversity
Year: 2022
Subjects: Data mining and knowledge discovery

description: Over the past several years, there has been an explosion in the amount of medical data generated and subsequently collected in medical domain. Data mining techniques have been used extensively in mining the medical data. Obtaining high quality data mining results is very challenging because of the inconsistency of the results of different data mining algorithms and noise in the medical data. This thesis presents a novel hybrid data mining approach for knowledge extraction and classification in medical databases. The proposed approach is formulated to cluster extracted features from medical databases into soft clusters using unsupervised learning strategies and fuse the decisions using serial and parallel data fusion techniques. The idea is to observe associations in the features and fuse the decisions made by learning algorithms to find the strong clusters which can make impact on overall classification accuracy. The novel techniques such as serial cascaded data fusion, parallel majority-voting based neural data fusion and parallel neural network based data fusion are proposed that allow integration of various clustering algorithms for hybrid data mining approach. The proposed approach has been implemented and evaluated on the benchmark databases such as Digital Database for Screening Mammograms, Wisconsin Breast Cancer, Pima Indian Diabetics and ECG Heart Arrhythmia. A comparative performance analysis of the proposed hybrid data mining approach with other existing approaches for knowledge extraction and classification is presented. The experimental results demonstrate the effectiveness of the proposed approach in terms of improved classification accuracy on benchmark medical databases.
Insights into the properties of the Local (Orion) spiral arm. NGC 2302: First results and description of the program
Creators: name: Costa, E.
name: Moitinho, A.
name: Radiszc, M.
name: Munoz, R.
name: Carraro, G.
name: Vazquez, R.
name: Servajean, E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The spiral structure of the Milky Way is highly uncertain and is the subject of much discussion nowadays. We present the first result from a program that determines the properties of the Local spiral arm (LOA), together with a full description of the program. In this context we have made a comprehensive study of the young LOA open cluster NGC 2302, which includes a UBVRI photometric analysis and determination of its kinematic properties - proper motion and radial velocity - and of its orbital parameters. We determined the mean PM of NGC 2302 relative to the local field of disk stars, and, through a comparison with the UCAC4 catalog, we transformed this relative PM into an absolute one. Using medium-resolution spectroscopy of 26 stars in the field of NGC 2302, we derived its mean RV. Isochrone fits to the photometric diagrams allowed us to determine the fundamental parameters of NGC 2302, including reddening, distance, and age. The kinematic data and derived distance allowed us to determine the space motion of NGC 2302. This was done by adopting a time-independent, axisymmetric, and fully analytic gravitational potential for the MW. We obtained an absolute PM for NGC 2302 of ($μ_α \cosδ,μ_δ) = (-2.09,-2.11)$ mas/yr, with standard errors of 0.410 and 0.400 mas/yr. The mean RV of NGC 2302 turned out to be 31.2 km/sec with a standard error of 0.7 km/sec. Isochrone fits displaced for this reddening and for a distance modulus of (m-M)o = 10.69 indicate an age of log(t) = 7.90-8.00 with a slight tendency toward the younger age. Inspection of the shape of the orbit of NGC 2302 and the resulting orbital parameters indicate that it is a typical population I object.
description: 14 pages, 9 eps figures, in press in Astronomy and Astrophysics
Garcinia erythrosperma Lauterbach 1922
Creators: name: Nazre, M.
name: Newman, M. F.
name: Pennington, R. T.
name: Middleton, D. J.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Malpighiales
Clusiaceae
Garcinia
Garcinia erythrosperma

description: Garcinia erythrosperma Lauterbach (1922: 26).
 Type:— PAPUA NEW GUINEA, Hunstein Range, Hunsteinspitze, 4 March 1913, Ledermann 11305 (B, destroyed, WRSL, lost).
 Tree 10–12 m high, slender. Bole with grey-brown bark. Exudate yellow. Twigs subangular, longitudinally wrinkled when dry. Petiole 12–15 mm long; coarse towards lamina. Lamina lanceolate, 10–15 × 5–7 cm, coriaceous, apex acuminate and short, base acute; margin sub-revolute; secondary veins brochidodromous, c. 20 pairs, prominent. Male flowers terminal, solitary, pedicel thick, as long as petiole; sepals 4, persistent, sub-coriaceous, 2 small, lanceolate, sub-acute, 2 larger, concave, widely ovate, subrotundate; staminodes c. 12, free, filaments thread like; anthers elliptic, 2-thecous, dehiscent longitudinally. Female flowers not seen. Fruits yellow, globose, 4.5 cm diameter; pedicel 15 mm long; sepals persistent 7–10 × 4–9 mm; stigma with 8–9 nearly free lobes, 10 mm across; pericarp fleshy; seeds c. 8, lanceolate or crescent shaped, 12–17 × 4–8 mm long, covered by dark red aril with a reddish black seed when dry.
 Distribution and Habitat:—Mossy montane forest of Papua New Guinea.
 Taxonomic Notes:—The description of this species is taken from Lauterbach (1922) as we have not seen any specimens. The original type material in Berlin was destroyed during the Second World War. Duplicate material was traced in Wroc ł aw (WRSL) but the specimen was lost in the post to Edinburgh.
description: Published as part of Nazre, M., Newman, M. F., Pennington, R. T. & Middleton, D. J., 2018, Taxonomic Revision of Garcinia Section Garcinia (Clusiaceae), pp. 1-52 in Phytotaxa 373 (1) on page 46, DOI: 10.11646/phytotaxa.373.1.1, http://zenodo.org/record/13727567
TLR3 agonist and CD40-targeting vaccination induces immune responses and reduces HIV-1 reservoirs
Creators: name: Zurawski, Sandra
name: Levy, Yves
name: Zhang, Zheng
name: Pantaleo, Giuseppe
name: Perreau, Matthieu
name: Yasui, Fumihiko
name: Yu, Haisheng
name: Li, Guangming
name: Su, Lishan
name: Ma, Jianping
name: Wang, Li
name: Banga, Riddhima
name: Cheng, Liang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: Activation of HIV-1 reservoirs and induction of anti–HIV-1 T cells are critical to control HIV-1 rebound after combined
antiretroviral therapy (cART). Here we evaluated in humanized mice (hu-mice) with persistent HIV-1 infection the therapeutic
effect of TLR3 agonist and a CD40-targeting HIV-1 vaccine, which consists of a string of 5 highly conserved CD4+ and CD8+
T cell epitope-rich regions of HIV-1 Gag, Nef, and Pol fused to the C-terminus of a recombinant anti-human CD40 antibody
(αCD40.HIV5pep). We show that αCD40.HIV5pep vaccination coadministered with poly(I:C) adjuvant induced HIV-1–specific
human CD8+ and CD4+ T cell responses in hu-mice. Interestingly, poly(I:C) treatment also reactivated HIV-1 reservoirs.
When administrated in therapeutic settings in HIV-1–infected hu-mice under effective cART, αCD40.HIV5pep with poly(I:C)
vaccination induced HIV-1–specific CD8+ T cells and reduced the level of cell-associated HIV-1 DNA (or HIV-1 reservoirs) in
lymphoid tissues. Most strikingly, the vaccination significantly delayed HIV-1 rebound after cART cessation. In summary,
the αCD40.HIV5pep with poly(I:C) vaccination approach both activates replication of HIV-1 reservoirs and enhances the anti–
HIV-1 T cell response, leading to a reduced level of cell-associated HIV-1 DNA or reservoirs. Our proof-of-concept study has
significant implication for the development of CD40-targeting HIV-1 vaccine to enhance anti–HIV-1 immunity and reduce HIV-1
reservoirs in patients with suppressive cART.
اثر توافق الفرد مع لوظيفة والمنظمة على اداء المهام والاداء السياقي : نية ترك الخدمة كوسيط في الغلاقة
Creators: name: الشركسي, أبوبكر
Publisher: name: figshare
Year: 2023
Subjects: Business systems in context

description: اثر توافق الفرد مع لوظيفة والمنظمة على اداء المهام والاداء السياقي ودور نية ترك الخدمة كوسيط في الغلاقة
Weighing neutrinos with cosmic neutral hydrogen
Creators: name: Villaescusa-Navarro, Francisco
name: Bull, Philip
name: Viel, Matteo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We investigate the signatures left by massive neutrinos on the spatial distribution of neutral hydrogen (HI) in the post-reionization era by running hydrodynamic simulations that include massive neutrinos as additional collisionless particles. We find that halos in massive/massless neutrino cosmologies host a similar amount of neutral hydrogen, although for a fixed halo mass, on average, the HI mass increases with the sum of the neutrino masses. Our results show that HI is more strongly clustered in cosmologies with massive neutrinos, while its abundance, $Ω_{\rm HI}(z)$, is lower. These effects arise mainly from the impact of massive neutrinos on cosmology: they suppress both the amplitude of the matter power spectrum on small scales and the abundance of dark matter halos. Modelling the HI distribution with hydrodynamic simulations at $z > 3$, and a simple analytic model at $z<3$, we use the Fisher matrix formalism to conservatively forecast the constraints that Phase 1 of the Square Kilometre Array (SKA) will place on the sum of neutrino masses, $M_ν\equiv Σm_ν$. We find that with 10,000 hours of interferometric observations at $3 \lesssim z \lesssim 6$ from a deep and narrow survey with SKA1-LOW, the sum of the neutrino masses can be measured with an error $σ(M_ν)\lesssim0.3$ eV (95% CL). Similar constraints can be obtained with a wide and deep SKA1-MID survey at $z \lesssim 3$, using the single-dish mode. By combining data from MID, LOW, and Planck, plus priors on cosmological parameters from a Stage IV spectroscopic galaxy survey, the sum of the neutrino masses can be determined with an error $σ(M_ν)\simeq0.06$ eV (95% CL).
description: 20 pages, 11 figures, 5 tables. ApJ in press
Vpr Targets TET2 for Degradation by CRL4 VprBP E3 Ligase to Sustain IL-6 Expression and Enhance HIV-1 Replication
Creators: name: Xiong, Yue
name: Wang, Qi
name: Su, Lishan
name: Guo, Haitao
name: Nakagawa, Tadashi
name: Lv, Lei
name: Tsao, Li-Chung
name: Xu, Yanping
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: HIV-1 expresses several accessory proteins to counteract host anti-viral restriction factors to facilitate viral replication and disease progression. One such protein, Vpr, has been implicated in affecting multiple cellular processes, but its mechanism remains elusive. Here we report that Vpr targets TET2 for polyubiquitylation by the VprBP-DDB1-CUL4-ROC1 E3 ligase and subsequent degradation. Genetic inactivation or Vpr-mediated degradation of TET2 enhances HIV-1 replication and substantially sustains expression of the pro-inflammatory cytokine interleukin-6 (IL-6). This process correlates with reduced recruitment of histone deacetylase 1 and 2 to the IL-6 promoter, thus enhancing its histone H3 acetylation level during resolution phase. Blocking IL-6 signaling reduced the ability of Vpr to enhance HIV-1 replication. We conclude that HIV-1 Vpr degrades TET2 to sustain IL-6 expression to enhance viral replication and disease progression. These results suggest that disrupting the Vpr-TET2-IL6 axis may prove clinically beneficial to reduce both viral replication and inflammation during HIV-1 infection. HIV-1 Vpr protein counteracts host anti-viral restriction factors to facilitate viral replication and disease progression. Lv et al. demonstrate that Vpr promotes degradation of TET DNA dioxygenases. TET2 deletion or depletion enhances HIV-1 replication and sustains pro-inflammatory cytokine IL-6, while blocking IL-6 reduces Vpr's ability to enhance HIV-1 replication. © 2018 Elsevier Inc.
Interpreting postoperative physiology prior to complications using continuous vital sign monitoring
Creators: name: Mølgaard, Jesper
Publisher: name: Zenodo
Year: 2023
Subjects: physiology
vital signs
complications
serious adverse events
thesis

description: PhD thesis "Interpreting postoperative physiology preceding complications using continuous vital sign monitoring" Jesper Mølgaard 1. To which extent are postoperative vital sign deviations associated with
 preoperative vital sign deviations?
 2. What is the difference between circadian vital sign values in
 postoperative patients with vs. without complications?
 3. If we provide patient care staff with continuous vital sign values and
 notifications of deviations from physiologic normal ranges, will this
 reduce the duration of severely deviating vital signs, further, does that
 mean that we can prevent complications?
description: {"references": ["Continuous wireless pre\u2010and postoperative vital sign monitoring reveal new, severe desaturations after vascular surgery J M\u00f8lgaard, SS Rasmussen, J Eiberg, HBD S\u00f8rensen, CS Meyhoff, ... Acta Anaesthesiologica Scandinavica 67 (1), 19-28"]}
Garcinia lucens Pierre 1883
Creators: name: Nazre, M.
name: Newman, M. F.
name: Pennington, R. T.
name: Middleton, D. J.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Malpighiales
Clusiaceae
Garcinia
Garcinia lucens

description: Garcinia lucens Pierre (1883b: xxxvii).
 Type:— INDONESIA East Kalimantan, Borneo, 1879, Korthals s.n. (Holotype L; isotypes: BO! P!).
 Tree: size not known. Exudate: not known. Twigs slightly angled, pale brown to cream. Petiole stout, transversely striate, angled, 1.6–2 cm long. Lamina thinly leathery, elliptic to ovate, 12.5–16 × 4.9–7.7 cm, apex acute with a blunt apex, base broadly acute to obtuse; midrib flattened to slightly raised above, raised and pointed below; margin entire and weakly revolute; secondary veins brochidodromous. Glands fine, in wavy longitudinal lines, running nearly parallel to the midrib. Inflorescences terminal, only males known, in clusters of 3–10 flowers; sepals and petals 4. Male flowers:[in bud] with pedicel longer than petiole, to 25 mm; sepals ovate to broadly elliptic, 3.6–4 × 2.8–3.1 cm; petals oblong-elliptic, 3–3.5 × 5.5–6.2 cm; stamens in an annular mass, surrounding half of the pistillode; pistillode a slender fungiform shape, tipped by a 4-lobed cap; anthers 2-thecous. Female flowers not seen. Fruit Unknown.
 Distribution and Habitat:—Lowland forest in East Kalimantan.
 Taxonomic Notes:—This species is represented by several collections by Korthals of male and sterile specimens, possibly from one locality in Kalimantan. No other specimens have been found. Although it has the distinct character of a long pedicel, the male flower is still in bud making it difficult to study.
description: Published as part of Nazre, M., Newman, M. F., Pennington, R. T. & Middleton, D. J., 2018, Taxonomic Revision of Garcinia Section Garcinia (Clusiaceae), pp. 1-52 in Phytotaxa 373 (1) on page 46, DOI: 10.11646/phytotaxa.373.1.1, http://zenodo.org/record/13727567
Determination of gamma-ray widths in $^{15}$N using nuclear resonance fluorescence
Creators: name: Szücs, T.
name: Bemmerer, D.
name: Caciolli, A.
name: Fülöp, Zs.
name: Massarczyk, R.
name: Michelagnoli, C.
name: Reinhardt, T. P.
name: Schwengner, R.
name: Takács, M. P.
name: Ur, C. A.
name: Wagner, A.
name: Wagner, L.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The stable nucleus $^{15}$N is the mirror of $^{15}$O, the bottleneck in the hydrogen burning CNO cycle. Most of the $^{15}$N level widths below the proton emission threshold are known from just one nuclear resonance fluorescence (NRF) measurement, with limited precision in some cases. A recent experiment with the AGATA demonstrator array determined level lifetimes using the Doppler Shift Attenuation Method (DSAM) in $^{15}$O. As a reference and for testing the method, level lifetimes in $^{15}$N have also been determined in the same experiment. The latest compilation of $^{15}$N level properties dates back to 1991. The limited precision in some cases in the compilation calls for a new measurement in order to enable a comparison to the AGATA demonstrator data. The widths of several $^{15}$N levels have been studied with the NRF method. The solid nitrogen compounds enriched in $^{15}$N have been irradiated with bremsstrahlung. The $γ$-rays following the deexcitation of the excited nuclear levels were detected with four HPGe detectors. Integrated photon-scattering cross sections of ten levels below the proton emission threshold have been measured. Partial gamma-ray widths of ground-state transitions were deduced and compared to the literature. The photon scattering cross sections of two levels above the proton emission threshold, but still below other particle emission energies have also been measured, and proton resonance strengths and proton widths were deduced. Gamma and proton widths consistent with the literature values were obtained, but with greatly improved precision.
description: Final published version, minor grammar changes, 10 pages, 4 figures, 8 tables; An addendum is published where the last section is revised: T. Sz\"ucs and P. Mohr, Phys. Rev. C 92, 044328 (2015) [arXiv:1510.04956]
Changing perspectives: Formulations of identity in contemporary Australian literature
Creators: name: Hall, Ayesha E
Publisher: name: CQUniversity
Year: 2022
Subjects: Australian literature (excl. Aboriginal and Torres Strait Islander literature)
Culture, representation and identity

description: Questions of identity occupy a central place in the history of the development of Australian literature and its critical construction and reception. The notions of identity appealed to in the various stages of this development have been closely imbricated with prevailing cultural and critical assumptions and practices. The model of identity that was appealed to in earlier periods of Australian literature and its academic criticism was understandably circumscribed by the Anglo-centric prescriptions of the Colonial Convict period, embellished but not significantly changed by the influence of the Bush Pioneers and a growing Nationalist sentiment enhanced by the spirit of the first world war Anzacs. While, as with all identity models, this one suffered its own ambiguities and slippages, it did successfully exercise a hegemony, reinforced by the then dominant academic practices, that largely excluded the identity experiences of Indigenous people, non-white immigrants, women and those whose sexual orientations lay outside of the parameters of heteronormativity. The Identities that have subsequently been articulated by such previously excluded groups and taken up by those within the academy influenced by developments in postcolonial, feminist, poststructural and postmodern (including Queer) theory have effectively functioned to dismantle the hegemony exerted by earlier unitary and reductive notions of Australian identity. Previously neglected areas of Australian writing such as Indigenous, multicultural and youth literature, as representations of minority identities have articulated often oppositional conceptions of identity to those formulated within the former orthodoxy. Such texts, most particularly those more recent ones which engage with radical rearticulations of sexual identity, have increasingly moved towards fluid conceptions of identity which ultimately serve to pose the question of the usefulness of the unqualified notion The Australian Identity as a meaningful category of analysis for the literature now being produced within Australia.
Global Regularity for the Two-dimensional Boussinesq Equations Without Diffusivity in Bounded Domains
Creators: name: Zhou, Daoguo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35Q35, 76D05

description: We address the well-posedness for the two-dimensional Boussinesq equations with zero diffusivity in bounded domains. We prove global in time regularity for rough initial data: both the initial velocity and temperature have $ε$ fractional derivatives in $L^{q}$ for some $q>2$ and $ε>0$ arbitrarily small.
description: Minor revision
Infection and depletion of CD4+group-1 innate lymphoid cells by HIV-1 via type-I interferon pathway
Creators: name: Chen, Weiwei
name: Yu, Haisheng
name: Zhang, Xin
name: Wang, Hongbo
name: Zhang, ligup
name: Fu, Qiang
name: Liu, Zhenwen
name: Zhang, Zheng
name: Tu, Bo
name: Zhao, Juanjuan
name: Su, Lishan
name: Li, Guangming
name: Wang, Qi
name: Sun, Yanling
name: Cheng, Liang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: Innate lymphoid cells (ILCs) are severely depleted during chronic HIV-1 infection by unclear mechanisms. We report here that human ILC1s comprising of CD4+and CD4-subpopulations were present in various human lymphoid organs but with different transcription programs and functions. Importantly, CD4+ILC1s expressed HIV-1 co-receptors and were productively infected by HIV-1 in vitro and in vivo. Furthermore, chronic HIV-1 infection activated and depleted both CD4+and CD4-ILC1s, and impaired their cytokine production activity. Highly active antiretroviral (HAART) therapy in HIV-1 patients efficiently rescued the ILC1 numbers and reduced their activation, but failed to restore their functionality. We also found that blocking type-I interferon (IFN-I) signaling during HIV-1 infection in vivo in humanized mice prevented HIV-1 induced depletion or apoptosis of ILC1 cells. Therefore, we have identified the CD4+ILC1 cells as a new target population for HIV-1 infection, and revealed that IFN-I contributes to the depletion of ILC1s during HIV-1 infection.
Laplacian State Transfer in Coronas
Creators: name: Ackelsberg, Ethan
name: Brehm, Zachary
name: Chan, Ada
name: Mundinger, Joshua
name: Tamon, Christino
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Combinatorics (math.CO)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We prove that the corona product of two graphs has no Laplacian perfect state transfer whenever the first graph has at least two vertices. This complements a result of Coutinho and Liu who showed that no tree of size greater than two has Laplacian perfect state transfer. In contrast, we prove that the corona product of two graphs exhibits Laplacian pretty good state transfer, under some mild conditions. This provides the first known examples of families of graphs with Laplacian pretty good state transfer. Our result extends of the work of Fan and Godsil on double stars to the Laplacian setting. Moreover, we also show that the corona product of any cocktail party graph with a single vertex graph has Laplacian pretty good state transfer, even though odd cocktail party graphs have no perfect state transfer.
description: 12 pages, 4 figures
On the distinguished spectrum of $Sp_{2n}$ with respect to $Sp_n\times Sp_n$
Creators: name: Lapid, Erez
name: Offen, Omer
Publisher: name: arXiv
Year: 2015
Subjects: subject: Number Theory (math.NT)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics

description: Given a reductive group $G$ and a reductive subgroup $H$, both defined over a number field $F$, we introduce the notion of the $H$-distinguished automorphic spectrum of $G$ and analyze it for the pairs $(GL_{2n},Sp_n)$ and $(Sp_{2n},Sp_n\times Sp_n)$. In the first case we give a complete description using results of Jacquet--Rallis, Offen and Yamana. In the second case we give an upper bound, generalizing vanishing results of Ash--Ginzburg--Rallis and a lower bound, extending results of Ginzburg--Rallis--Soudry.
Garcinia moulmeinensis Vesque 1893
Creators: name: Nazre, M.
name: Newman, M. F.
name: Pennington, R. T.
name: Middleton, D. J.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Malpighiales
Clusiaceae
Garcinia
Garcinia moulmeinensis

description: Garcinia moulmeinensis Pierre ex Vesque (1893: 394).
 Type:— MYANMAR, Moulmein, 1885, Wallich 4852E (Holotype: BR; isotypes: K-W!, P!).
 Size not known. Exudate not known. Twigs not known. Petiole short, 5–9 mm long. Lamina leathery, elliptic or oblong, 11.7–12.5 × 3.7–6 cm, pale brown, apex sharply acute or not, base broadly acute or nearly round; margin entire and revolute; midrib flattened above and raised below; secondary veins fine, visible below, a mixture of eucamptodromous and cladodromous, running nearly parallel, at c. 85º from the midrib; glandular lines faint, fine and inconspicuous below. Inflorescences perhaps terminal, in clusters of 4–6 flowers; sepals and petals 4. Male flowers not found. Female flowers nearly sessile or with a short pedicel, to 3 mm long; sepals membranous, broadly ovate; petals concave, to 5 mm long; staminodes absent; ovary short, tipped by 6-lobed, convex stigma. Fruit not found.
 Distribution and Habitat:—Lowland forest in Myanmar.
 Taxonomic Notes:—Represented only by the type specimens with immature and detached flowers.
description: Published as part of Nazre, M., Newman, M. F., Pennington, R. T. & Middleton, D. J., 2018, Taxonomic Revision of Garcinia Section Garcinia (Clusiaceae), pp. 1-52 in Phytotaxa 373 (1) on page 46, DOI: 10.11646/phytotaxa.373.1.1, http://zenodo.org/record/13727567
Proteus mirabilis C05028 Genome sequencing
Creators: name: BGI
Publisher: name: CNGB
Year: 2012
Subjects: Genome sequencing and assembly
Monoisolate

description: This is a strain isolated from the stool of a diarrhea patient in the foodborne disease outbreak in Shenzhen, China, 2005. roteus mirabilis is a Gram-negative, facultatively anaerobic, rod shaped bacterium. It shows swarming motility, and urease activity. P. mirabilis causes 90% of all Proteus infections in humans.