cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Structure of the Local Interstellar Medium. VI. New MgII, FeII, and MnII Observations Toward Stars Within 100 Parsecs
Creators: name: Malamut, Craig
name: Redfield, Seth
name: Linsky, Jeffrey L.
name: Wood, Brian E.
name: Ayres, Thomas R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We analyze high-resolution spectra obtained with the Space Telescope Imaging Spectrograph onboard the Hubble Space Telescope toward 34 nearby stars (<100 pc) to record MgII, FeII and MnII absorption due to the local interstellar medium (LISM). Observations span the entire sky, probing previously unobserved regions of the LISM. We detected one to six individual absorption components along any given sight line, and the number of absorbers roughly correlates with the pathlength. This high-resolution near-ultraviolet (NUV) spectroscopic survey was specifically designed for sight lines with existing far-UV (FUV) observations. The FUV spectra include many intrinsically broad absorption lines (i.e., of low atomic mass ions) and often observed at medium resolution. The LISM NUV narrow-line absorption component structure presented here can be used to more accurately interpret the archival FUV observations. As an example of this synergy, we present a new analysis of the temperature and turbulence along the line of sight toward epsilon Ind. The new observations of LISM velocity structure are also critical in the interpretation of astrospheric absorption derived from fitting the saturated HI Lyman-alpha profile. As an example, we reanalyze the spectrum of lambda And and find that this star likely does have an astrosphere. Two stars in the sample that have circumstellar disks (49 Cet and HD141569) show evidence for absorption due to disk gas. Finally, the substantially increased number of sight lines is used to test and refine the three-dimensional kinematic model of the LISM, and search for previously unidentified clouds within the Local Bubble. We find that every prediction made by the Redfield & Linsky (2008) kinematic model of the LISM is confirmed by an observed component in the new lines of sight.
description: 58 pages, 25 figures. Accepted for publication in ApJ
Variational Truncated Wigner Approximation
Creators: name: Sels, Dries
name: Brosens, Fons
Publisher: name: arXiv
Year: 2013
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In this paper we reconsider the notion of an optimal effective Hamiltonian for the semiclassical propagation of the Wigner distribution in phase space. An explicit expression for the optimal effective Hamiltonian is obtained in the short time limit by minimizing the Hilbert-Schmidt distance between the semiclassical approximation and the real state of the system. The method is illustrated for the quartic oscillator.
title: Gene Expression Profiling of Islet Cell Subtypes
Creators: name: Blodgett, David M.
name: Pechhold, Susanne
name: Pechhold, Klaus
name: Harlan, David
Publisher: name: eScholarship@UMMS
Year: 2011

description: Abstract

Pancreatic endocrine cells are co-located into clusters called the islets of Langerhans that are comprised of glucagon producing alpha cells, insulin secreting beta cells, somatostatin generating delta cells, and other cell types. Type 1 diabetes results from an autoimmune process in which autoreactive T cells destroy the insulin producing beta cells, requiring the patient to inject insulin to regulate their blood glucose levels. Thus far, attempts to cure diabetes via islet transplantation have been limited by insufficient donor supply, inconsistent isolated islet quality, continued autoimmunity, alloimmune rejection, and limited beta cell regeneration. Diabetes research has focused on preventing the autoimmune response, promoting stem cell to beta cell differentiation, and defining the factors that influence beta cell proliferation. Islet research, in turn, has been limited to whole islet studies since, isolating the islet cell subtypes has not been possible. Using a method recently developed for mouse islet cells (Pechhold et al. Nat Biotechnol. 2009 Nov; 27(11):1038-42), that uses intracellular hormone staining and flow cytometry, we are able to sort human islets into populations uniquely expressing glucagon, insulin, or somatostatin. Further, we have developed a human gene array to measure candidate gene expression using a quantitative nuclease protection assay (qNPA). This technique uses 50 base oligomers that specifically recognize RNA from each gene of interest, overcoming limitations caused by the harsh conditions required for intracellular staining. We report gene expression analysis for specific hormones and transcription factors expressed in each islet cell population. We are further modifying this technique to study nonhuman primate islets, and investigate the specific proteome and miRNA profiles for individual islet cell populations. The goal of these studies is to characterize the genetic differences between the islet cell populations and understand which factors control beta cell regeneration and proliferation. We have shown that we can purify adult human islets into individual cellular populations. This is the first step in understanding the genetic and environmental components that regulate increased beta cell proliferation and beta cell mass. In the absence of full-length mRNA for RT-PCR or next generation sequencing, the qNPA technique provides candidate gene expression profiles for these cells.
Charmless B -> PPP Decays: the Fully-Symmetric Final State
Creators: name: Bhattacharya, Bhubanjyoti
name: Gronau, Michael
name: Imbeault, Maxime
name: London, David
name: Rosner, Jonathan L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In charmless B -> PPP decays, where P is a pseudoscalar meson, there are six possibilities for the symmetry of the final state. In this paper, for P=pi,K, we examine the properties of the fully-symmetric final state. We present expressions for all 32 B -> PPP decay amplitudes as a function of both SU(3) reduced matrix elements and diagrams, demonstrating the equivalence of diagrams and SU(3). We also give 25 relations among the amplitudes in the SU(3) limit, as well as those that appear when the diagrams E/A/PA are neglected. In the SU(3) limit, one has the equalities \sqrt{2} A(B+ -> K+ pi+ pi-)_{FS} = A(B+ -> K+ K+ K-)_{FS} and \sqrt{2} A(B+ -> pi+ K+ K-)_{FS} = A(B+ -> pi+ pi+ pi-)_{FS}, where FS denotes the fully-symmetric final state. These provide good tests of the standard model that can be carried out now by the LHCb Collaboration.
description: 24 pages, 1 figure. Several more detailed explanations added. Analysis and conclusions unchanged
Additional file 1 of Oral corticosteroids for post-infectious cough in adults: study protocol for a double-blind randomized placebo-controlled trial in Swiss family practices (OSPIC trial)
Creators: name: Merlo, Christoph
name: Essig, Stefan
name: D. Oana Brancati-Badarau
name: Leuppi, Jörg Daniel
name: Speich, Benjamin
name: Erlanger, Tobias E.
name: Hemkens, Lars G.
name: Zeller, Andreas
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Additional file 1. Ethical approval documents: a copy translated into English and a copy of the original document in German
Robustness of community structure under edge addition
Creators: name: Tian, Moyi
name: Moriano, Pablo
Publisher: name: arXiv
Year: 2023
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Social and Information Networks (cs.SI)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Communities often represent key structural and functional clusters in networks. To preserve such communities, it is important to understand their robustness under network perturbations. Previous work in community robustness analysis has focused on studying changes in the community structure as a response of edge rewiring and node or edge removal. However, the impact of increasing connectivity on the robustness of communities in networked systems is relatively unexplored. Studying the limits of community robustness under edge addition is crucial to better understanding the cases in which density expands or false edges erroneously appear. In this paper, we analyze the effect of edge addition on community robustness in synthetic and empirical temporal networks. We study two scenarios of edge addition: random and targeted. We use four community detection algorithms, Infomap, Label Propagation, Leiden, and Louvain, and demonstrate the results in community similarity metrics. The experiments on synthetic networks show that communities are more robust when the initial partition is stronger or the edge addition is random, and the experiments on empirical data also indicate that robustness performance can be affected by the community similarity metric. Overall, our results suggest that the communities identified by the different types of community detection algorithms exhibit different levels of robustness, and so the robustness of communities depends strongly on the choice of detection method.
description: 17 pages, 30 figures
title: Pilot Testing a Novel Treatment for Inflammatory Bowel Disease
Creators: name: Olendzki, Barbara C.
name: Persuitte, Gioia
name: Silverstein, Taryn
name: Baldwin, Katherine
name: Cave, David
name: Zawacki, John K.
name: Bhattacharya, Kanishka
name: Ma, Yunsheng
Publisher: name: eScholarship@UMMS
Year: 2011

description: Background: Inflammatory Bowel Disease (IBD), which includes Crohn’s disease (CD) and ulcerative colitis (UC), are chronic non specific inflammatory conditions. Standard IBD treatment typically employs a combination of anti-inflammatory and immune suppressive medications; however, the pharmacological approach is not by itself curative. The Anti-Inflammatory Diet for IBD (IBD-AID), which is derived and augmented from The Specific Carbohydrate Diet (SCD), is a nutritional regimen that restricts the intake of complex carbohydrates such as refined sugar, gluten-based grains, and certain starches from the diet. These carbohydrates are thought to provide a substrate for pro-inflammatory bacteria. The second component of the diet involves the ingestion of pre- and probiotics to help restore an anti inflammatory environment.

Study Objective: To assess the efficacy and feasibility of the Anti –Inflammatory Diet (IBD-AID) intervention for the treatment of IBD.

Intervention: Patients were recruited from the UMMHC gastroenterology clinic upon referral from their gastroenterologist. They received individual instruction of the diet and its restrictions through 5 individual nutrition sessions over approximately a 6-10 month period. Support materials were provided. Cooking classes were also available to the patients.

Conclusion: This case series indicates the potential for the IBD-AID to be used as an adjunctive or alternative therapy for the treatment of IBD. Notably, 9 out of 11 patients were able to be managed without anti-TNF therapy, and 100% of the patients had their symptoms reduced. To make clear recommendations for its use in clinical practice, randomized trials are needed alongside strategies to improve acceptability and compliance with the IBD-AID.
title: So trainieren Sie Ihren Gedächtnismuskel
Creators: name: Margelisch, Katja
Publisher: name: Weber Verlag
Year: 2022

description: Möglichst lange ein gutes Gedächtnis zu haben, das ist wohl für die meisten Menschen ein erstrebenswertes Ziel. Auch wenn das Gehirn kein Muskel ist, lässt es sich gemäss neuropsychologischen Erkenntnissen sehr wohl trainieren. Doch aufgepasst: Im gesunden Mass ist auch das Vergessen gesund.
Results of the SDHCAL technological prototype
Creators: name: Steen, Arnaud
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The SDHCAL technological prototype that has been completed in 2012 was exposed to beams of pions and electrons of different energies at the CERN SPS for a total time period of 5 weeks. The data has been analyzed within the CALICE collaboration. Preliminary results indicate that a highly granular hadronic calorimeter conceived for PFA application is also a powerful tool to separate pions from electrons. The SDHCAL provides also a very good resolution of hadronic showers energy measurement. The use of multi-threshold readout mode shows a clear improvement of the resolution at energies exceeding 30 GeV with respect to the binary readout mode. Simulations of the pion interactions in the SDHCAL are presented and new ideas to improve on the energy resolution using the topology of hadronic showers are mentioned.
description: Talk presented at the International Workshop on Future Linear Colliders (LCWS13), Tokyo, Japan, 11-15 November 2013
Subsystem Non-Invertible Symmetry Operators and Defects
Creators: name: Cao, Weiguang
name: Li, Linhao
name: Yamazaki, Masahito
name: Zheng, Yunqin
Publisher: name: arXiv
Year: 2023
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We explore non-invertible symmetries in two-dimensional lattice models with subsystem $\mathbb Z_2$ symmetry. We introduce a subsystem $\mathbb Z_2$-gauging procedure, called the subsystem Kramers-Wannier transformation, which generalizes the ordinary Kramers-Wannier transformation. The corresponding duality operators and defects are constructed by gaugings on the whole or half of the Hilbert space. By gauging twice, we derive fusion rules of duality operators and defects, which enriches ordinary Ising fusion rules with subsystem features. Subsystem Kramers-Wannier duality defects are mobile in both spatial directions, unlike the defects of invertible subsystem symmetries. We finally comment on the anomaly of the subsystem Kramers-Wannier duality symmetry, and discuss its subtleties.
description: 47 pages, 10 figures; v2: references added
Additional file 1 of Meal replacement in dietary management of type-2 diabetes mellitus: a scoping review protocol
Creators: name: Chen, Lew Leong
name: Ludin, Arimi Fitri Mat
name: Shahar, Suzana
name: Manaf, Zahara Abdul
name: Noorlaili Mohd Tohit
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. PRISMA-P 2015 Checklist
Einstein rings modulated by wavelike dark matter from anomalies in gravitationally lensed images
Creators: name: Amruth, Alfred
name: Broadhurst, Tom
name: Lim, Jeremy
name: Oguri, Masamune
name: Smoot, George F.
name: Diego, Jose M.
name: Leung, Enoch
name: Emami, Razieh
name: Li, Juno
name: Chiueh, Tzihong
name: Schive, Hsi-Yu
name: Yeung, Michael C. H.
name: Li, Sung Kei
Publisher: name: arXiv
Year: 2023
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Popular Physics (physics.pop-ph)
subject: FOS: Physical sciences

description: Unveiling the true nature of Dark Matter (DM), which manifests itself only through gravity, is one of the principal quests in physics. Leading candidates for DM are weakly interacting massive particles (WIMPs) or ultralight bosons (axions), at opposite extremes in mass scales, that have been postulated by competing theories to solve deficiencies in the Standard Model of particle physics. Whereas DM WIMPs behave like discrete particles ($\varrho$DM), quantum interference between DM axions is manifested as waves ($ψ$DM). Here, we show that gravitational lensing leaves signatures in multiply-lensed images of background galaxies that reveal whether the foreground lensing galaxy inhabits a $\varrho$DM or $ψ$DM halo. Whereas $\varrho$DM lens models leave well documented anomalies between the predicted and observed brightnesses and positions of multiply-lensed images, $ψ$DM lens models correctly predict the level of anomalies left over by $\varrho$DM lens models. More challengingly, when subjected to a battery of tests for reproducing the quadruply-lensed triplet images in the system HS 0810+2554, $ψ$DM is able to reproduce all aspects of this system whereas $\varrho$DM often fails. The ability of $ψ$DM to resolve lensing anomalies even in demanding cases like HS 0810+2554, together with its success in reproducing other astrophysical observations, tilt the balance toward new physics invoking axions.
description: Updated with accepted version. The Version of Record of this article is published in Nature Astronomy, and is available online at https://www.nature.com/articles/s41550-023-01943-9. Free online version : https://rdcu.be/damHj
title: Effects of high-intensity interval exercise versus moderate continuous exercise on glucose homeostasis and hormone response in patients with type 1 diabetes mellitus using novel ultra-long-acting insulin
Creators: name: Moser, Othmar
name: Tschakert, Gerhard
name: Mueller, Alexander
name: Groeschl, Werner
name: Pieber, Thomas R.
name: Obermayer-Pietsch, Barbara
name: Koehler, Gerd
name: Hofmann, Peter
Publisher: name: Universität Potsdam
Year: 2019

description: Introduction

We investigated blood glucose (BG) and hormone response to aerobic high-intensity interval exercise (HIIE) and moderate continuous exercise (CON) matched for mean load and duration in type 1 diabetes mellitus (T1DM).

Material and Methods

Seven trained male subjects with T1DM performed a maximal incremental exercise test and HIIE and CON at 3 different mean intensities below (A) and above (B) the first lactate turn point and below the second lactate turn point (C) on a cycle ergometer. Subjects were adjusted to ultra-long-acting insulin Degludec (Tresiba/Novo Nordisk, Denmark). Before exercise, standardized meals were administered, and short-acting insulin dose was reduced by 25% (A), 50% (B), and 75% (C) dependent on mean exercise intensity. During exercise, BG, adrenaline, noradrenaline, dopamine, cortisol, glucagon, and insulin-like growth factor-1, blood lactate, heart rate, and gas exchange variables were measured. For 24 h after exercise, interstitial glucose was measured by continuous glucose monitoring system.

Results

BG decrease during HIIE was significantly smaller for B (p = 0.024) and tended to be smaller for A and C compared to CON. No differences were found for post-exercise interstitial glucose, acute hormone response, and carbohydrate utilization between HIIE and CON for A, B, and C. In HIIE, blood lactate for A (p = 0.006) and B (p = 0.004) and respiratory exchange ratio for A (p = 0.003) and B (p = 0.003) were significantly higher compared to CON but not for C.

Conclusion

Hypoglycemia did not occur during or after HIIE and CON when using ultra-long-acting insulin and applying our methodological approach for exercise prescription. HIIE led to a smaller BG decrease compared to CON, although both exercises modes were matched for mean load and duration, even despite markedly higher peak workloads applied in HIIE. Therefore, HIIE and CON could be safely performed in T1DM.
description: Postprints der Universität Potsdam : Humanwissenschaftliche Reihe, 497
The metric structure of compact rank-one ECS manifolds
Creators: name: Derdzinski, Andrzej
name: Terek, Ivo
Publisher: name: arXiv
Year: 2023
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 53C50

description: Pseudo-Riemannian manifolds with nonzero parallel Weyl tensor which are not locally symmetric are known as ECS manifolds. Every ECS manifold carries a distinguished null parallel distribution $\mathcal{D}$, the rank $d \in \{ 1, 2 \}$ of which is referred to as the rank of the manifold itself. Under a natural genericity assumption on the Weyl tensor, we fully describe the universal coverings of compact rank-one ECS manifolds. We then show that any generic compact rank-one ECS manifold must be translational, in the sense that the holonomy group of the natural flat connection induced on $\mathcal{D}$ is either trivial or isomorphic to $\mathbb{Z}_2$. We also prove that all four-dimensional rank-one ECS manifolds are noncompact, this time without assuming genericity, as it is always the case in dimension four.
description: References updated, typos fixed, and other stylistic improvements
Additional file 1 of Influence of vitamin D binding protein polymorphism, demographics and lifestyle factors on vitamin D status of healthy Malaysian pregnant women
Creators: name: Siew-Siew Lee
name: King-Hwa Ling
name: Maiza Tusimin
name: Subramaniam, Raman
name: Kartini Farah Rahim
name: Loh, Su-Peng
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Questionnaire used in this study.
Additional file 4 of Extracellular vesicles from young women’s breast cancer patients drive increased invasion of non-malignant cells via the Focal Adhesion Kinase pathway: a proteomic approach
Creators: name: Jordan, Kimberly R.
name: Hall, Jessica K.
name: Schedin, Troy
name: Borakove, Michelle
name: Xian, Jenny J.
name: Dzieciatkowska, Monika
name: Lyons, Traci R.
name: Pepper Schedin
name: Hansen, Kirk C.
name: Borges, Virginia F.
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Plant Biology

description: Additional file 4. Proteins identified by volcano plot comparing EVs from healthy donors and YWBC patients, tabulated data of the volcano plot shown in Fig. 3.
Research Ethics in Complex Humanitarian Emergencies: Summary of a Workshop
Publisher: name: Online Ethics Center
Year: 2016
Subjects: Catastrophes, Hazards, Disasters
Controversies
Diversity
Ethics and Society
Human Migration
Human Rights
Human Subjects Research
Privacy and Surveillance
Public Well-being
Safety
Social and Political Conflict
Social Responsibility

description: Link to the National Academies Report,Research Ethics in Complex Humanitarian Emergencies: Summary of a Workshop
Recursive Local Fractional Derivative
Creators: name: Kolwankar, Kiran M.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: The definition of the local fractional derivative has been generalised to the orders beyond the critical order. This makes it possible to retain more terms in the local fractional Taylor expansion leading to better approximation. This also extends the validity of the product rule.
COVID-19 Spreading Prediction and Impact Analysis by Using Artificial Intelligence for Sustainable Global Health Assessment
Creators: name: Adhikary, Subhrangshu
name: Chaturvedi, Sonam
name: Chaturvedi, Sudhir Kumar
name: Banerjee, Saikat
Publisher: name: arXiv
Year: 2023
Subjects: subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: The COVID-19 pandemic is considered as the most alarming global health calamity of this century. COVID-19 has been confirmed to be mutated from coronavirus family. As stated by the records of The World Health Organization (WHO at April 18 2020), the present epidemic of COVID-19, has influenced more than 2,164,111 persons and killed more than 146,198 folks in over 200 countries across the globe and billions had confronted impacts in lifestyle because of this virus outbreak. The ongoing overall outbreak of the COVID-19 opened up new difficulties to the research sectors. Artificial intelligence (AI) driven strategies can be valuable to predict the parameters, hazards, and impacts of such an epidemic in a cost-efficient manner. The fundamental difficulties of AI in this situation is the limited availability of information and the uncertain nature of the disease. Here in this article, we have tried to integrate AI to predict the infection outbreak and along with this, we have also tried to test whether AI with help deep learning can recognize COVID-19 infected chest X-Rays or not. The global outbreak of the virus posed enormous economic, ecological and societal challenges into the human population and with help of this paper, we have tried to give a message that AI can help us to identify certain features of the disease outbreak that could prove to be essential to protect the humanity from this deadly disease.
description: Advances in Environment Engineering and Management. Year 2021. Springer Proceedings in Earth and Environmental Sciences. Springer, Cham. https://doi.org/10.1007/978-3-030-79065-3_30
Additional file 3 of Extracellular vesicles from young women’s breast cancer patients drive increased invasion of non-malignant cells via the Focal Adhesion Kinase pathway: a proteomic approach
Creators: name: Jordan, Kimberly R.
name: Hall, Jessica K.
name: Schedin, Troy
name: Borakove, Michelle
name: Xian, Jenny J.
name: Dzieciatkowska, Monika
name: Lyons, Traci R.
name: Pepper Schedin
name: Hansen, Kirk C.
name: Borges, Virginia F.
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Plant Biology

description: Additional file 3. EVs isolated from different subsets of YWBC patients increased invasion of MCF10DCIS.com breast cancer cells, clinical characteristics of functional EVs shown in Fig. 2.
Additional file 1 of CXCR7: a β-arrestin-biased receptor that potentiates cell migration and recruits β-arrestin2 exclusively through Gβγ subunits and GRK2
Creators: name: Nguyen, Huong Thi
name: Arfaxad Reyes-Alcaraz
name: Yong, Hyo Jeong
name: Nguyen, Lan Phuong
name: Park, Hee-Kyung
name: Inoue, Asuka
name: Lee, Cheol Soon
name: Seong, Jae Young
name: Hwang, Jong-Ik
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology

description: Additional File 1: Fig. S1. Ligand-stimulated real-time luciferase activities in HEK293 cells expressing different combinations of NanoBit constructs ofCXCR7 and β-arrestin2. Fig. S2. Ligand-stimulated real-time luciferase activities in HEK293 cells expressing different combinations of NanoBit constructs of β-arrestin2 with CXCR4 or CXCR3. Fig. S3. Receptor internalization assay using NanoBit constructs. (a) Cells expressing receptor-LgBiT and SmBiT-FYVE domain of EEA1 were treated with SDF-1α and the luciferase activities were measured in real-time. (b) Cells expressing receptor-SmBiT and LgBiT-CAAX sequence were used in the NanoBit assay. Fig. S4. Optimization of NanoBit construct combinations of Gb1 and GRKs. a and b showed luciferase activities in cells expressing different combinations of NanoBiT constructs. Fig. S5. Optimization of NanoBit construct combinations of receptor and GRK2. Fig. S6. Generation of cells lacking receptors using CRISPR system. (a) Genomic DNA PCR products from cells established with CRISPRCas9were cloned and sequenced. Red color designates guide RNA target regions. (b) RT-PCR products of either CXCR4 or CXCR7 were compared in wild-type and receptor KO HeLa cell clones. β-actin products were used as the control. (c) Membrane expression of exogenous receptors was not affected by deletion of CXCR4 or CXCR7. HiBiT constructs of the receptors were expressed in wild-type and receptor KO of HEK293 and HeLa cells, and the cells were applied to the HiBiT assay.
Electronic relaxation rates in metallic ferromagnets
Creators: name: Bharadwaj, S.
name: Belitz, D.
name: Kirkpatrick, T. R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We show that the single-particle and transport relaxation rates in ferromagnetic metals, which determine the thermal and electrical conductivity, respectively, at asymptotically low temperature do not obey a power law as previously thought, but rather show an exponential temperature dependence. The reason is the splitting of the conduction band that inevitably results from a nonzero magnetization. At higher temperatures there is a sizable temperature window where the transport rate shows a T^2 temperature dependence, in accord with prior results. This window is separated from the asymptotic regime by a temperature scale that is estimated to range from tens of mK to tens of K for typical ferromagnets. We motivate and derive a very general effective theory for metallic magnets that we then use to derive these results. Comparisons with existing experiments are discussed, and predictions for future experiments at low temperatures are made.
description: 14pp, 3 figs; expanded discussion
title: Role of inflammatory monocytes in adolescent metabolic syndrome
Creators: name: Hardy, Olga T.
name: Kim, Albert
name: Ciccarelli, Carol
name: Hayman, Laura L.
name: Wiecha, Jean
Publisher: name: eScholarship@UMMS
Year: 2011

description: Metabolic syndrome (MetSyn) is a cluster of risk factors for cardiovascular disease and diabetes that affects 1 in 3 obese children. Inflammatory cytokines secreted from macrophages are thought to be partly responsible for the metabolic abnormalities associated with MetSyn. This study aimed to determine whether peripheral blood monocytes (macrophage precursors) from overweight individuals with MetSyn (Overwt-MetSyn) demonstrate enhanced activation of inflammatory signaling pathways when compared to metabolically normal overweight (Overwt-Healthy) or lean individuals. We conducted a cross sectional pilot study involving 24 adolescents (six boys and eighteen girls) recruited from the University of Massachusetts Boston and Worcester campuses. Six subjects were classified as Overwt-MetSyn using a modified definition proposed by the International Diabetes Federation. The Overwt-MetSyn group demonstrated an elevated expression of TLR2 and TLR4 in peripheral monocytes, and increased circulating levels of TNFa and IL6. Expression of TLR2 and TLR4 showed a positive correlation with circulating cytokines, and expression of TNFa correlated with waist circumference and BMI. Metabolic syndrome in adolescents is associated with increased activation of the TLR signaling pathway in monocytes. The knowledge gained from this study will advance our understanding of the contribution of monocytes to the pathophysiology of MetSyn.
Additional file 2 of Extracellular vesicles from young women’s breast cancer patients drive increased invasion of non-malignant cells via the Focal Adhesion Kinase pathway: a proteomic approach
Creators: name: Jordan, Kimberly R.
name: Hall, Jessica K.
name: Schedin, Troy
name: Borakove, Michelle
name: Xian, Jenny J.
name: Dzieciatkowska, Monika
name: Lyons, Traci R.
name: Pepper Schedin
name: Hansen, Kirk C.
name: Borges, Virginia F.
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Plant Biology

description: Additional file 2. Isolation of human EVs from plasma of healthy donor and breast cancer patients, results of the size exclusion chromatography separation of EVs.
FVP: Fourier Visual Prompting for Source-Free Unsupervised Domain Adaptation of Medical Image Segmentation
Creators: name: Wang, Yan
name: Cheng, Jian
name: Chen, Yixin
name: Shao, Shuai
name: Zhu, Lanyun
name: Wu, Zhenzhou
name: Liu, Tao
name: Zhu, Haogang
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Medical image segmentation methods normally perform poorly when there is a domain shift between training and testing data. Unsupervised Domain Adaptation (UDA) addresses the domain shift problem by training the model using both labeled data from the source domain and unlabeled data from the target domain. Source-Free UDA (SFUDA) was recently proposed for UDA without requiring the source data during the adaptation, due to data privacy or data transmission issues, which normally adapts the pre-trained deep model in the testing stage. However, in real clinical scenarios of medical image segmentation, the trained model is normally frozen in the testing stage. In this paper, we propose Fourier Visual Prompting (FVP) for SFUDA of medical image segmentation. Inspired by prompting learning in natural language processing, FVP steers the frozen pre-trained model to perform well in the target domain by adding a visual prompt to the input target data. In FVP, the visual prompt is parameterized using only a small amount of low-frequency learnable parameters in the input frequency space, and is learned by minimizing the segmentation loss between the predicted segmentation of the prompted target image and reliable pseudo segmentation label of the target image under the frozen model. To our knowledge, FVP is the first work to apply visual prompts to SFUDA for medical image segmentation. The proposed FVP is validated using three public datasets, and experiments demonstrate that FVP yields better segmentation results, compared with various existing methods.
title: Validation of Acute Myocardial Infarction (AMI) in the FDA’s Mini-Sentinel Distributed Database
Creators: name: Cutrona, Sarah L.
name: Toh, Darren
name: Iyer, Aarthi
name: Foy, Sarah
name: Cavagnaro, Elizabeth
name: Forrow, Susan
name: Goldberg, Robert J.
name: Gurwitz, Jerry H.
Publisher: name: eScholarship@UMMS
Year: 2011

description: The Food and Drug Administration’s (FDA) Mini-Sentinel is a pilot program that aims to conduct active surveillance to detect and refine safety signals that emerge for marketed medical products.

The purpose of this Mini-Sentinel AMI Validation project was to:

(a) develop and design an abstraction and adjudication process to use when full text medical record review is required to confirm a coded diagnosis; and

(b) to test this approach by validating a code algorithm for acute myocardial infarction (AMI).
A pedagogical overview of quantum discord
Creators: name: Modi, Kavan
Publisher: name: arXiv
Year: 2013
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Recent measures of nonclassical correlations are motivated by different notions of classicality and operational means. Quantum discord has received a great deal of attention in studies involving quantum computation, metrology, dynamics, many-body physics, and thermodynamics. In this article I show how quantum discord is different from quantum entanglement from a pedagogical point of view. I begin with a pedagogical introduction to quantum entanglement and quantum discord, followed by a historical review of quantum discord. Next, I give a novel definition of quantum discord in terms of any classically extractable information, a approach that is fitting for the current avenues of research. Lastly, I put forth several arguments for why discord is an interesting quantity to study and why it is of interest to so many researchers in the community.
description: 17 pages, 6 figures, to appear in special OSID volume of on open systems
Additional file 1 of Extracellular vesicles from young women’s breast cancer patients drive increased invasion of non-malignant cells via the Focal Adhesion Kinase pathway: a proteomic approach
Creators: name: Jordan, Kimberly R.
name: Hall, Jessica K.
name: Schedin, Troy
name: Borakove, Michelle
name: Xian, Jenny J.
name: Dzieciatkowska, Monika
name: Lyons, Traci R.
name: Pepper Schedin
name: Hansen, Kirk C.
name: Borges, Virginia F.
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Plant Biology

description: Additional file 1. Clinical Characteristics of Enrolled Patients, study subject information.
title: Effects of a multicomponent wellness intervention on dyslipidemia in an overweight adolescent population
Creators: name: Hardy, Olga T.
name: Wiecha, Jean
name: Kim, Albert
name: Salas, Carlos
name: Bricenoc, Rayna
name: Moody, Kwesi
name: Becker, Joan
name: Glazer, Greer
name: Ciccarelli, Carol A.
name: Shi, Ling
name: Hayman, Laura L.
Publisher: name: eScholarship@UMMS
Year: 2011

description: Epidemiologic studies suggest that atherosclerotic processes begin in childhood and are associated with abnormal lipid levels. Behavioral changes are the first line of treatment for dyslipidemia in adolescents but outcome data on the effectiveness of this approach are inconsistent. This study aimed to assess the effect of a 13-week multicomponent wellness intervention program on dyslipidemia in lean and overweight/obese adolescents enrolled at a public high school in Boston, Massachusetts. The intervention was conducted at a university-based youth fitness center where 9 overweight/obese adolescents (body mass index [BMI]≥85th percentile for age and sex) and 9 lean adolescents (BMIsex) participated in weekly nutrition classes and structured cardiovascular, flexibility and strength training 2 times/week for 5 weeks, followed by up to 4 times/week for 8 weeks. Clinical measurements (BMI, percent body fat, blood pressure [BP]) and lipid profile assessment (total cholesterol [TC], high-density lipoprotein cholesterol [HDL-C], triglycerides [TG], and low-density lipoprotein cholesterol [LDL-C]) were performed at baseline and at completion of the intervention. At the completion of the study, the overweight/obese adolescents demonstrated a 15% increase in HDL-C levels (mean, 47 mg/dL vs 54 mg/dL) while there was no improvement in BMI, percent body fat, BP,TG, TC and LDL-C. The participants in the lean group showed no change in their anthropometric and serum parameters. A multicomponent wellness intervention resulted in a significant increase of cardioprotective HDL-C levels which has been associated with coronary health in adulthood. The long-term effects of this intervention on indicators of cardiometabolic health and others like it require further study.
Geometric singular perturbation theory for stochastic differential equations
Creators: name: Berglund, Nils
name: Gentz, Barbara
Publisher: name: Weierstrass Institute
Year: 2002
Subjects: subject: Singular perturbations
subject: slow-fast systems
subject: invariant manifolds
subject: dynamic bifurcations
subject: stochastic differential equations
subject: first-exit times
subject: concentration of measure
subject: 37H20
subject: 34E15
subject: 60H10

description: We consider slow-fast systems of differential equations, in which both the slow and fast variables are perturbed by additive noise. When the deterministic system admits a uniformly asymptotically stable slow manifold, we show that the sample paths of the stochastic system are concentrated in a neighbourhood of the slow manifold, which we construct explicitly. Depending on the dynamics of the reduced system, the results cover time spans which can be exponentially long in the noise intensity squared (that is, up to Kramers' time). We give exponentially small upper and lower bounds on the probability of exceptional paths. If the slow manifold contains bifurcation points, we show similar concentration properties for the fast variables corresponding to non-bifurcating modes. We also give conditions under which the system can be approximated by a lower-dimensional one, in which the fast variables contain only bifurcating modes.
Influence of Different 3SAT-to-QUBO Transformations on the Solution Quality of Quantum Annealing: A Benchmark Study
Creators: name: Zielinski, Sebastian
name: Nüßlein, Jonas
name: Stein, Jonas
name: Gabor, Thomas
name: Linnhoff-Popien, Claudia
name: Feld, Sebastian
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: To solve 3SAT instances on quantum annealers they need to be transformed to an instance of Quadratic Unconstrained Binary Optimization (QUBO). When there are multiple transformations available, the question arises whether different transformations lead to differences in the obtained solution quality. Thus, in this paper we conduct an empirical benchmark study, in which we compare four structurally different QUBO transformations for the 3SAT problem with regards to the solution quality on D-Wave's Advantage_system4.1. We show that the choice of QUBO transformation can significantly impact the number of correct solutions the quantum annealer returns. Furthermore, we show that the size of a QUBO instance (i.e., the dimension of the QUBO matrix) is not a sufficient predictor for solution quality, as larger QUBO instances may produce better results than smaller QUBO instances for the same problem. We also empirically show that the number of different quadratic values of a QUBO instance, combined with their range, can significantly impact the solution quality.
Additional file 5 of Adverse effects of Z-drugs for sleep disturbance in people living with dementia: a population-based cohort study
Creators: name: Richardson, Kathryn
name: Loke, Yoon K.
name: Fox, Chris
name: Maidment, Ian
name: Howard, Robert
name: Steel, Nicholas
name: Arthur, Antony
name: Boyd, Penelope J.
name: Aldus, Clare
name: Ballard, Clive
name: Savva, George M.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: 60506 Virology

description: Additional file 5. Additional exclusion criteria, frequency of missing data, dose changes during follow-up, additional analysis results tables and flowchart of patient selection.
On the Casimir operator dependences of QCD amplitudes
Creators: name: Grandou, T.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In eikonal and quenched approximations at least, it is argued that the strong coupling fermionic QCD amplitudes obtained with the help of the newly discovered effective locality property, depart from a dependence on the sole $SU_c(3)$ quadratic Casimir operator, evaluated over the fundamental gauge group representation. This result, in contradistinction with Perturbation Theory, but also with a number of non-perturbative approaches such as the MIT Bag, the Stochastic Vacuum Models, and Lattice simulations, accounts, instead, for the full algebraic content of the rank-2 $SU_c(3)$-Lie algebra
description: New Eq.(6) is more general than the previous one, and is further detailed by Eqs.(7) and (8). Conclusion is a bit more detailed, and the References completed with the titles of articles
title: Advancing Stage of Female Reproductive Life Associated with Bipolar Illness Exacerbation
Creators: name: Marsh, Wendy K.
name: Ketter, Terence
name: Crawford, Sybil L.
name: Johnson, Julia V.
name: Rothschild, Anthony J.
Publisher: name: eScholarship@UMMS
Year: 2011

description: Introduction: Perimenopause confers an increased risk of depression in the general population, yet bipolar disorder mood course remains unknown.

Methods: Clinic visits in 519 premenopausal, 116 perimenopausal including 13 women transitioning from peri- to postmenopause, and 133 postmenopausal women with bipolar disorder who received naturalistic treatment in the multisite STEP-Bipolar Disorder study over 19.8 +/- 15.5 months were analyzed for mood state.

Results: Advancing female reproductive stage was associated with significant decline in mood elevation; significant decline in euthymia; no significant difference in major depression; and symptomatic significant increase.

Conclusions: Advancing stage of female reproductive life was associated with bipolar illness exacerbation. Women transitioning from peri- to postmenopause had significantly greater depression than other female reproductive groups.
Additional file 4 of Adverse effects of Z-drugs for sleep disturbance in people living with dementia: a population-based cohort study
Creators: name: Richardson, Kathryn
name: Loke, Yoon K.
name: Fox, Chris
name: Maidment, Ian
name: Howard, Robert
name: Steel, Nicholas
name: Arthur, Antony
name: Boyd, Penelope J.
name: Aldus, Clare
name: Ballard, Clive
name: Savva, George M.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: 60506 Virology

description: Additional file 4. Study protocol registration, Definition of covariates and Multiple Imputation Methods.
Pattern QUBOs: Algorithmic construction of 3SAT-to-QUBO transformations
Creators: name: Zielinski, Sebastian
name: Nüßlein, Jonas
name: Stein, Jonas
name: Gabor, Thomas
name: Linnhoff-Popien, Claudia
name: Feld, Sebastian
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: 3SAT instances need to be transformed into instances of Quadratic Unconstrained Binary Optimization (QUBO) to be solved on a quantum annealer. Although it has been shown that the choice of the 3SAT-to-QUBO transformation can impact the solution quality of quantum annealing significantly, currently only a few 3SAT-to-QUBO transformations are known. Additionally, all of the known 3SAT-to-QUBO transformations were created manually (and not procedurally) by an expert using reasoning, which is a rather slow and limiting process. In this paper, we will introduce the name Pattern QUBO for a concept that has been used implicitly in the construction of 3SAT-to-QUBO transformations before. We will provide an in-depth explanation for the idea behind Pattern QUBOs and show its importance by proposing an algorithmic method that uses Pattern QUBOs to create new 3SAT-to-QUBO transformations automatically. As an additional application of Pattern QUBOs and our proposed algorithmic method, we introduce approximate 3SAT-to-QUBO transformations. These transformations sacrifice optimality but use significantly fewer variables (and thus physical qubits on quantum hardware) than non-approximate 3SAT-to-QUBO transformations. We will show that approximate 3SAT-to-QUBO transformations can nevertheless be very effective in some cases.