cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Workshop to Identify Critical Windows of Exposure for Children's Health: Neurobehavioral Work Group Summary
Creators: name: Rice, D.C.
name: Spear, Linda
name: Barone, Stan
name: Susser, Ezra
name: LaMantia, Anthony
name: Philen, Rossanne
name: Adams, Jane
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: This paper summarizes the deliberations of a work group charged with addressing specific questions relevant to risk estimation in developmental neurotoxicology. We focused on eight questions. a) Does it make sense to think about discrete windows of vulnerability in the development of the nervous system? If it does, which time periods are of greatest importance? b) Are there cascades of developmental disorders in the nervous system? For example, are there critical points that determine the course of development that can lead to differences in vulnerabilities at later times? c) Can information on critical windows suggest the most susceptible subgroups of children (i.e., age groups, socioeconomic status, geographic areas, race, etc.)? d) What are the gaps in existing data for the nervous system or end points of exposure to it? e) What are the best ways to examine exposure-response relationships and estimate exposures in vulnerable life stages? f) What other exposures that affect development at certain ages may interact with exposures of concern? g) How well do laboratory animal data predict human response? h) How can all of this information be used to improve risk assessment and public health (risk management)? In addressing these questions, we provide a brief overview of brain development from conception through adolescence and emphasize vulnerability to toxic insult throughout this period. Methodological issues focus on major variables that influence exposure or its detection through disruptions of behavior, neuroanatomy, or neurochemical end points. Supportive evidence from studies of major neurotoxicants is provided.
ПОПУЛЯРИЗАЦИЯ БИОЛОГИЧЕСКОЙ ЗАЩИТЫ РАСТЕНИЙ – В СЛУЧАЕ ЧАСТИЧНОГО ОТКАЗА ОТ ВРЕДНЫХ ДЛЯ ОРГАНИЗМА ЧЕЛОВЕКА ХИМИКАТОВ.
Creators: name: Рузиев, Рахматжон
name: Собирова, Ирода
name: Чутбаев, Сардор
Publisher: name: Zenodo
Year: 2023

description: Широкое применение биологических методов при выращивании высококачественной продукции из сельскохозяйственных культур, с небольшим содержанием вредных для организма человека веществ, а также в борьбе с болезнями растений и вредными насекомыми с целью достижения высокой продуктивности.
An Invertebrate Model of the Developmental Neurotoxicity of Insecticides: Effects of Chlorpyrifos and Dieldrin in Sea Urchin Embryos and Larvae
Creators: name: Lauder, Jean M.
name: Slotkin, Theodore A.
name: Nikitina, Lyudmila A.
name: Buznikov, Gennady A.
name: Padilla, Stephanie
name: Bezuglov, Vladimir V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Chlorpyrifos targets mammalian brain development through a combination of effects directed at cholinergic receptors and intracellular signaling cascades that are involved in cell differentiation. We used sea urchin embryos as an invertebrate model system to explore the cellular mechanisms underlying the actions of chlorpyrifos and to delineate the critical period of developmental vulnerability. Sea urchin embryos and larvae were exposed to chlorpyrifos at different stages of development ranging from early cell cleavages through the prism stage. Although early cleavages were unaffected even at high chlorpyrifos concentrations, micromolar concentrations added at the mid-blastula stage evoked a prominent change in cell phenotype and overall larval structure, with appearance of pigmented cells followed by their accumulation in an extralarval cap that was extruded from the animal pole. At higher concentrations (20-40 microM), these abnormal cells constituted over 90% of the total cell number. Studies with cholinergic receptor blocking agents and protein kinase C inhibitors indicated two distinct types of effects, one mediated through stimulation of nicotinic cholinergic receptors and the other targeting intracellular signaling. The effects of chlorpyrifos were not mimicked by chlorpyrifos oxon, the active metabolite that inhibits cholinesterase, nor by nonorganophosphate cholinesterase inhibitors. Dieldrin, an organochlorine that targets GABA(A )receptors, was similarly ineffective. The effects of chlorpyrifos and its underlying cholinergic and signaling-related mechanisms parallel prior findings in mammalian embryonic central nervous system. Invertebrate test systems may thus provide both a screening procedure for potential neuroteratogenesis by organophosphate-related compounds, as well as a system with which to uncover novel mechanisms underlying developmental vulnerability.
Assessing Exposure to Disinfection By-products in Women of Reproductive Age Living in Corpus Christi, Texas, and Cobb County, Georgia: Descriptive Results and Methods
Creators: name: Bonin, Michael
name: Ashley, David
name: Langlois, Peter
name: Henry, Judy
name: Tadkod, Altaf
name: Mendola, Pauline
name: Lin, Bruce
name: Speight, Vanessa
name: Miles, Amy
name: Small, Leanne
name: Nuckols, J.R.
name: Wilkes, Charles
name: Lynberg, Michele
name: Forrester, Mathias B.
name: Singer, Philip
name: Zeitz, Perri
name: Krapfl, Heidi
name: Miles, Eileen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: We conducted a field study in Corpus Christi, Texas, and Cobb County, Georgia, to evaluate exposure measures for disinfection by-products, with special emphasis on trihalomethanes (THMs). Participants were mothers living in either geographic area who had given birth to healthy infants from June 1998 through May 1999. We assessed exposure by sampling blood and water and obtaining information about water use habits and tap water characteristics. Two 10-mL whole blood samples were collected from each participant before and immediately after her shower. Levels of individual THM species (chloroform, bromodichloromethane, dibromochloromethane, and bromoform) were measured in whole blood [parts per trillion (pptr)] and in water samples (parts per billion). In the Corpus Christi water samples, brominated compounds accounted for 71% of the total THM concentration by weight; in Cobb County, chloroform accounted for 88%. Significant differences in blood THM levels were observed between study locations. For example, the median baseline blood level of bromoform was 0.3 pptr and 3.5 pptr for participants in Cobb County and Corpus Christi, respectively (p = 0.0001). Differences were most striking in blood obtained after showering. For bromoform, the median blood levels were 0.5 pptr and 17 pptr for participants in Cobb County and Corpus Christi, respectively (p = 0.0001). These results suggest that blood levels of THM species vary substantially across populations, depending on both water quality characteristics and water use activities. Such variation has important implications for epidemiologic studies of the potential health effects of disinfection by-products.
Vários, De doctrina loannis Duns Scoti. Acta Congressus Scotistici Internationalis. Ed. Commissio Scotistica. 4 vols. de XIX+438 ps. (Documenta et studia in Duns Scotum introductoria);
Creators: name: Faria, Manuel Ferreira De
Publisher: name: Theologica
Year: 1969

description: Theologica, v. 4 n. 1 (1969)
Bernd Wacker (Hg.), Die eigentlich katholische Verschärfung...Konfession, Theologie und Politik im Werk Carl Schmitts
Publisher: name: Herder Korrespondenz
Year: 1970

description: Herder Korrespondenz, Bd. 49 Nr. 9 (1995): Herder Korrespondenz, Band 49, Heft 9
Classification and Identification of Pfiesteria and Pfiesteria-Like Species
Creators: name: Reece, Kimberly
name: Mason, Patrice
name: Scott, Paula
name: Litaker, Wayne
name: Morton, Steve
name: Vasta, Gerardo
name: Richardson, R. William
name: Blakesley, Barbara
name: Steidinger, Karen
name: Tengs, Torstein
name: Haas, Leonard
name: Seaborn, David
name: Tester, Patricia
name: Landsberg, Jan
name: Truby, Earnest
name: Oldach, David
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Dinoflagellates can be classified both botanically and zoologically; however, they are typically put in the botanical division Pyrrhophyta. As a group they appear most related to the protistan ciliates and apicomplexans at the ultrastructure level. Within the Pyrrhophyta are both unarmored and armored forms of the dominant, motile flagellated stage. Unarmored dinoflagellates do not have thecal or wall plates arranged in specific series, whereas armored species have plates that vary in thickness but are specific in number and arrangement. In armored dinoflagellates, the plate pattern and tabulation is a diagnostic character at the family, subfamily, and even genus levels. In most cases, the molecular characterization of dinoflagellates confirms the taxonomy on the basis of external morphology; this has been demonstrated for several groups. Together, both genetic and morphological criteria are becoming increasingly important for the characterization, separation, and identification of dinoflagellates species. Pfiesteria and Pfiesteria-like species are thinly armored forms with motile dinospore stages characterized by their distinct plate formulae. Pfiesteria piscicida is the best-known member of the genus; however, there is at least one other species. Other genetically and morphologically related genera, now grouped under the common names of "Lucy," "Shepherd's crook," and cryptoperidiniopsoid, are being studied and described in separate works. All these other heterotrophic dinoflagellate groups, many of which are thought to be benign, co-occur in estuarine waters where Pfiesteria has been found.
Cohort Studies of Health Effects among People Exposed to Estuarine Waters: North Carolina, Virginia, and Maryland
Creators: name: Weber, David J.
name: Moe, Christine L.
name: Turf, Megan
name: Turf, Elizabeth
name: Oldach, David
name: Haselow, Dirk
name: Grattan, Lynn
name: Hart, Robert
name: Ball, J.D.
name: Wilson, Leslie
name: McCarter, Robert
name: Stutts, Michael
name: Bell, Paula
name: Ingsrisawang, Lily
name: Hutton, Steve
name: Koltai, Deborah
name: Morris, J. Glenn
name: Savitz, David
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: A variety of human symptoms have been associated with exposure to the dinoflagellate Pfiesteria and have been grouped together into a syndrome termed "possible estuary-associated syndrome." Prospective cohort studies of health effects associated with exposure to estuarine waters that may contain Pfiesteria spp. and related organisms are in progress in North Carolina, Virginia, and Maryland. The three studies recruited cohorts of 118-238 subjects who work or engaged in recreation in estuary waters. Baseline health and neuropsychological evaluations are conducted, and study subjects are followed prospectively for 2-5 years with periodic assessments of health and performance on a battery of neuropsychological tests. Health symptoms and estuary water exposure are recorded by telephone interviews or diaries every 1-2 weeks. Water quality information, including measurements of Pfiesteria spp., is collected in the areas where the subjects are working. Because it is not possible to measure individual exposure to Pfiesteria or a toxin produced by this organism, these studies examine surrogate exposure measures (e.g., time spent in estuary waters, in a fish kill area, or in waters where Pfiesteria DNA was detected by molecular amplification). Preliminary analyses of the first 2 years (1998-2000) of data indicate that none of the three ongoing cohorts have detected adverse health effects. However, there have not been any reported fish kills associated with Pfiesteria since the studies began, so it is possible that none of the study subjects have been exposed to toxin-producing Pfiesteria spp.
Investigation Into The Formation Of Volatile Sulphur Compounds In Cooked Hens Eggs
Creators: name: Flanders, Andrew
Publisher: name: London South Bank University
Year: 1981

description: This investigation was undertaken to examine the volatile sulphur compounds produced in cooked hens eggs and to determine the possible mechanisms by which such compounds are formed. The parameters for gas chromatographic analysis of mixtures of volatile sulphur compounds were determined for optimum separation. The response characteristics and operating conditions of a gas chromatographic flame photometric detector for the detection of sulphur were also investigated. Six methods for the isolation of volatile sulphur compounds from cooked hens eggs were evaluated, following which two were selected for further investigation. One of these methods incorporated extraction of the head space vapours of cooked hens eggs with diethyl ether, followed by liquid nitrogen cold-trapping of the mixed ethereal vapours. Eleven sulphur-containing volatiles were isolated in detectable quantities by this method. Despite the absence of artefact formation during the process, the method was found to isolate volatile sulphur compounds in a non-quantitative manner. The second method involved the adsorption of cooked egg volatiles on small columns containing Tenax GC, followed by direct desorption onto a gas chromatographic column. This porous polymer was found to effectively separate twenty-one sulphur-containing volatiles from cooked hens eggs in detectable quantities, and work with synthetic mixtures of sulphur compounds indicated that adsorption and desorption were quantitative. Artefacts did not appear to be formed at desorption temperatures. Five volatile sulphur compounds isolated by these techniques were tentatively identified by retention data and sensory evaluation of the eluted components. A modified inlet system was developed whereby a Tenax GC porous polymer pre-column could be linked directly to a Reoplex 400 capillary column. Some improvement in separation of volatile sulphur compounds was effected. This chromatographic system was interfaced with a mass spectrometer and as a result of gas chromatographic/mass spectrometric analyses six volatile sulphur compounds isolated from cooked hens eggs were identified. Volatile sulphur compounds produced in heated model systems of sulphur-containing amino acids and vitamins were separated and identified by gas chromatography/mass spectrometry. The proposed mechanisms by which the identified volatiles were formed are detailed. Information gained from these experiments has been used to elucidate the possible pathways of formation of the sulphur-containing volatiles identified in cooked hens eggs. " The differences between production of sulphur-containing volatiles in heated vitellin, albumen and specific albumen proteins have also been investigated.
Phase effects due to previous pulses in time-resolved Faraday rotation measurements
Creators: name: Trowbridge, Christopher J.
name: Sih, Vanessa
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Time-resolved Faraday rotation measurements have proved transformative in the investigation of spin dynamics in semiconductors. In materials with spin lifetimes which are on the order of, or greater than, the laser repetition time, the collective effect of spin polarization due to the whole pump pulse train becomes important. Here, we discuss a relative phase shift which results from these spins. We derive and experimentally validate a closed-form expression which describes this phase shift, and characterize it throughout parameter space. A spin lifetime measurement based on this phase shift is described, and we discuss situations in which the model used must be augmented to be applicable
description: 6 pages, with 5 figures
Differential Effects of Two Lots of Aroclor 1254 on Enzyme Induction, Thyroid Hormones, and Oxidative Stress
Creators: name: Kannan, Narayanan
name: Burgin, Deborah E.
name: Yamashita, Nobuyoshi
name: Tilson, Hugh A.
name: Birnbaum, Linda S.
name: Ward, Thomas R.
name: Kodavanti, Prasada Rao S.
name: Derr-Yellin, Ethel C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Aroclor 1254 is a commercial mixture of polychlorinated biphenyls (PCBs), which is defined as being 54% chlorine by weight. However, the congener composition varies from lot to lot. Two lots which have been used in toxicity studies, 124-191 and 6024 (AccuStandard), were analyzed for their congener composition. Lot 6024 has approximately 10 times the dioxin toxic equivalents (TEQ) of lot 124-191. The purpose of this study was to determine if the difference in the TEQ of the two lots explains the different in vivo responses seen on a weight basis. Male Long-Evans rats (70 days old) were treated orally with a single dose of 0-1,000 mg/kg of each lot. Hepatic ethoxy-, methoxy-, and pentoxyresorufin O-deethylase (EROD, MROD, and PROD, respectively) activities as well as serum thyroxine (T(4)) concentrations and measures of oxidative stress were determined 4 days after treatment. Results, on a weight basis, indicate that lot 6024 led to a greater induction of EROD, MROD, and PROD but not total T(4) reduction. The differences in TEQ between the lots explained the differential induction of EROD and MROD but did not account for the induction of PROD nor decreases in T(4). PROD induction is not due to dioxin-like congeners, whereas the decrease in serum T(4) levels may involve multiple mechanisms. Effects on the antioxidants ascorbic acid and uric acid were seen only at the highest mass dose for both lots and were not explained by the difference in TEQ. These results illustrate that the differences in the TEQ explain the differences in the strict dioxin-like effects (EROD, MROD induction), but the non-dioxin-like congeners cause other effects that are not associated with the aryl hydrocarbon receptor (e.g., PROD). In addition, supra-additive effects also occur in the mixture (T(4), oxidative stress). Thus, current results demonstrate that overall toxicity cannot be predicted on the basis of the TEQ values. It is also critical that the lot number is reported in studies conducted with Aroclor 1254 because the congener composition and therefore the effects observed can be very different.
Mechanistic Investigations on the Implications of mTORC1 and ER Stress Crosstalk in Hepatic Lipotoxicity
Creators: name: Griffiths, Alexandra M
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: Uncategorized

description: Non-alcoholic fatty liver disease (NAFLD) is a type of chronic liver disease intimately related to obesity and considered the hepatic manifestation of metabolic syndrome. A central mechanism underlying NAFLD pathogenesis is hepatic lipotoxicity, defined as the dysfunction and cell death caused by the accumulation of toxic lipids in hepatocytes. Despite intense investigations over last several decades, the exact mechanisms underscoring lipotoxicity remain elusive. Palmitate, a 16-C saturated fatty acid (SFA), is the most abundant SFA in human circulation and is widely used to induce lipotoxicity in cell culture systems. Using exogenous palmitate exposure of hepatocytes (AML-12 and primary hepatocytes) as our primary in vitro hepatolipotoxicity model, three Research Projects were conducted in this thesis to investigate the cellular and molecular mechanisms accounting for palmitate-induced cell death, with a focus on how endoplasmic reticulum (ER) stress and mTORC1 crosstalk to contribute to palmitate-induced lipotoxicity. We demonstrated that exogenous palmitate exposure induced ER stress and activated mTORC1 signaling pathway in hepatocytes, contributing to palmitate-elicited hepatocyte cell death. Further mechanistic investigations revealed that the cross-talk between these two pathways exists. We identified that mTORC1 activation was required for palmitate-elicited activation of IRE1alpha and ATF4, two of the three canonical signaling pathways activated by ER stress. Inhibition of either kinase activity or endoribonuclease activity of IRE1alpha ameliorated palmitate lipotoxicity, suggesting that the mTORC1-IRE1alpha pathway activation contributes to palmitate-induced lipotoxicity in hepatocytes (Project 1). We were the first to identify ATF4 as a transcription factor for hepatic nicotinamide N-methyltransferase (NNMT) expression. Here, we further demonstrated that NNMT upregulation derived from the mTORC1-ATF4 pathway activation contributes to palmitate-induced hepatocyte cell death via preserving PKA activity (Project 2). Finally, we showed that palmitate upregulated CD36 expression in a PPARγ-independent fashion in hepatocytes. Further mechanistic investigation unraveled that ATF4 activation plays a critical role in mediating palmitate-elicited hepatic CD36. Importantly, genetic knockdown of CD36 confers protection against palmitate-induced cell death, suggesting that the ATF4-CD36 pathway activation contributes to palmitate-induced hepatic lipotoxicity (Project 3). Collectively, studies in this thesis provide evidence that mTORC1 activation and ER stress induction coordinately implicate palmitate-induced hepatolipotoxicity.
Von Allmen, Jean Jacques e Outros. Vocabulaire Biblique. Edit. Delachux y Niestlé. Vol. de 318 ps. 175x240. Neuchâtel (Suíça) 1964
Creators: name: Arieiro, José
Publisher: name: Theologica
Year: 1969

description: Theologica, v. 4 n. 1 (1969)
Review of the Epidemiologic Literature on EMF and Health
Creators: name: Savitz, David
name: Swerdlow, Anthony
name: Ahlbom, Anders
name: Cardis, Elisabeth
name: Green, Adele
name: Linet, Martha
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Exposures to extremely low-frequency electric and magnetic fields (EMF) emanating from the generation, transmission, and use of electricity are a ubiquitous part of modern life. Concern about potential adverse health effects was initially brought to prominence by an epidemiologic report two decades ago from Denver on childhood cancer. We reviewed the now voluminous epidemiologic literature on EMF and risks of chronic disease and conclude the following: a) The quality of epidemiologic studies on this topic has improved over time and several of the recent studies on childhood leukemia and on cancer associated with occupational exposure are close to the limit of what can realistically be achieved in terms of size of study and methodological rigor. b) Exposure assessment is a particular difficulty of EMF epidemiology, in several respects: i) The exposure is imperceptible, ubiquitous, has multiple sources, and can vary greatly over time and short distances. ii) The exposure period of relevance is before the date at which measurements can realistically be obtained and of unknown duration and induction period. iii) The appropriate exposure metric is not known and there are no biological data from which to impute it. c) In the absence of experimental evidence and given the methodological uncertainties in the epidemiologic literature, there is no chronic disease for which an etiological relation to EMF can be regarded as established. d) There has been a large body of high quality data for childhood cancer, and also for adult leukemia and brain tumor in relation to occupational exposure. Among all the outcomes evaluated in epidemiologic studies of EMF, childhood leukemia in relation to postnatal exposures above 0.4 microT is the one for which there is most evidence of an association. The relative risk has been estimated at 2.0 (95% confidence limit: 1.27-3.13) in a large pooled analysis. This is unlikely to be due to chance but, may be, in part, due to bias. This is difficult to interpret in the absence of a known mechanism or reproducible experimental support. In the large pooled analysis only 0.8% of all children were exposed above 0.4 microT. Further studies need to be designed to test specific hypotheses such as aspects of selection bias or exposure. On the basis of epidemiologic findings, evidence shows an association of amyotrophic lateral sclerosis with occupational EMF exposure although confounding is a potential explanation. Breast cancer, cardiovascular disease, and suicide and depression remain unresolved.
MDPI-Figshare
Creators: name: Zhao, Jing
Publisher: name: figshare
Year: 2022
Subjects: subject: Biomarkers
subject: 111201 Cancer Cell Biology
subject: FOS: Clinical medicine
subject: 111202 Cancer Diagnosis
subject: 111203 Cancer Genetics
subject: 111204 Cancer Therapy (excl. Chemotherapy and Radiation Therapy)
subject: 111402 Obstetrics and Gynaecology

description: TRMT6 expression in OV
Conspiracy beliefs and majority influence
Creators: name: Pummerer, Lotte
name: Fock, Lukas
name: Winter, Kevin
name: Sassenberg, Kai
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Mental Health

description: Conspiracy beliefs (i.e. beliefs in specific conspiracy theories or the more general conspiracy mentality) are associated with a need for uniqueness and lower adherence to social norms. These findings suggest that conspiracy beliefs might be generally associated with less influence by majority opinions – absolutely and compared to minority opinions. In five experiments involving scenarios unrelated to conspiracy theories (overall N = 1669), participants were informed about the majority/minority opinion on a given issue (e.g. the building of a tunnel), afterward indicating their evaluation or voting intentions regarding the issue. We then tested whether the influence of a majority/minority opinion on evaluation or voting intentions is moderated by conspiracy beliefs. Across studies, we find no significant moderation. A meta-analysis confirms no correlation between conspiracy beliefs and susceptibility to majority influence. Taken together, our studies provide no evidence for the assumption that those holding conspiracy beliefs reject majority opinions per se.
Salas, Antonio, O. S. A., Discurso escatológico prelucano. Ed. Real Monasterio de el Escorial. Vol. de 236 ps. 170x240. Madrid 1967
Creators: name: Correia, Francisco Carvalho
Publisher: name: Theologica
Year: 1969

description: Theologica, v. 4 n. 1 (1969)
The Role of Nutrient Loading and Eutrophication in Estuarine Ecology
Creators: name: Pinckney, James L.
name: Richardson, Tammi L.
name: Tester, Patricia
name: Paerl, Hans W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Eutrophication is a process that can be defined as an increase in the rate of supply of organic matter (OM) to an ecosystem. We provide a general overview of the major features driving estuarine eutrophication and outline some of the consequences of that process. The main chemical constituent of OM is carbon (C), and therefore rates of eutrophication are expressed in units of C per area per unit time. OM occurs in both particulate and dissolved forms. Allochthonous OM originates outside the estuary, whereas autochthonous OM is generated within the system, mostly by primary producers or by benthic regeneration of OM. The supply rates of limiting nutrients regulate phytoplankton productivity that contributes to inputs of autochthonous OM. The trophic status of an estuary is often based on eutrophication rates and can be categorized as oligotrophic (<100 g C m(-2) y(-1), mesotrophic (100-300 g C m(-2) y(-1), eutrophic (300-500 g C m(-2) y(-1), or hypertrophic (>500 g C m(-2) y(-1). Ecosystem responses to eutrophication depend on both export rates (flushing, microbially mediated losses through respiration, and denitrification) and recycling/regeneration rates within the estuary. The mitigation of the effects of eutrophication involves the regulation of inorganic nutrient (primarily N and P) inputs into receiving waters. Appropriately scaled and parameterized nutrient and hydrologic controls are the only realistic options for controlling phytoplankton blooms, algal toxicity, and other symptoms of eutrophication in estuarine ecosystems.
ENES Data Space: an open, cloud-enabled data science environment for climate analysis
Creators: name: Antonio, Fabrizio
name: Elia, Donatello
name: Gianotta, Andrea
name: Nuzzo, Alessandra
name: Levavasseur, Guillaume
name: Ben Nasser, Atef
name: Nassisi, Paola
name: D'Anca, Alessandro
name: Fiore, Sandro
name: Joussaume, Sylvie
name: Giovanni, Aloisio
Publisher: name: Zenodo
Year: 2022

description: Presentation delivered at EGU 2022 (Vienna, Austria): The scientific discovery process has been deeply influenced by the data deluge started at the beginning of this century. This has caused a profound transformation in several scientific domains which are now moving towards much more collaborative processes. In the climate sciences domain, the ENES Data Space aims to provide an open, scalable, cloud-enabled data science environment for climate data analysis. It represents a collaborative research environment, deployed on top of the EGI federated cloud infrastructure, specifically designed to address the needs of the ENES community. The service, developed in the context of the EGI-ACE project, provides ready-to-use compute resources and datasets, as well as a rich ecosystem of open source Python modules and community-based tools (e.g., CDO, Ophidia, Xarray, Cartopy, etc.), all made available through the user-friendly Jupyter interface. In particular, the ENES Data Space provides access to a multi-terabyte set of specific variable-centric collections from large community experiments to support researchers in climate model data analysis experiments. The data pool of the ENES Data Space consists of a mirrored subset of CMIP datasets from the ESGF federated data archive collected by using the Synda community tool
 in order to provide the most up to date datasets into a single location. Results and output products as well as experiment definitions (in the form of Jupyter Notebooks) can be easily shared among users through data sharing services, which are also being integrated in the infrastructure, such as EGI DataHub. The service was opened in the second part of 2021 and is now accessible in the European Open Science Cloud (EOSC) through the EOSC Portal Marketplace (https://marketplace.eoscportal.eu/services/enes-data-space). This contribution will present an overview of the ENES Data Space service and its main features.
Assessing Exposure in Epidemiologic Studies to Disinfection By-Products in Drinking Water: Report from an International Workshop
Creators: name: Krasner, Stuart W.
name: Ashley, David L.
name: Nuckols, Jay R.
name: Froese, Kenneth L.
name: Richardson, Susan D.
name: Reif, John
name: Dodds, Linda
name: Waller, Kirsten
name: Lynberg, Michele
name: Benoit, Frank M.
name: Weisel, Clifford
name: Poole, Charles
name: Pegram, Rex A.
name: Schultz, Irvin R.
name: Singer, Philip
name: Arbuckle, Tye E.
name: Bachand, Annette M.
name: Hrudey, Steve E.
name: Mendola, Pauline
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: The inability to accurately assess exposure has been one of the major shortcomings of epidemiologic studies of disinfection by-products (DBPs) in drinking water. A number of contributing factors include a) limited information on the identity, occurrence, toxicity, and pharmacokinetics of the many DBPs that can be formed from chlorine, chloramine, ozone, and chlorine dioxide disinfection; b) the complex chemical interrelationships between DBPs and other parameters within a municipal water distribution system; and c) difficulties obtaining accurate and reliable information on personal activity and water consumption patterns. In May 2000, an international workshop was held to bring together various disciplines to develop better approaches for measuring DBP exposure for epidemiologic studies. The workshop reached consensus about the clear need to involve relevant disciplines (e.g., chemists, engineers, toxicologists, biostatisticians and epidemiologists) as partners in developing epidemiologic studies of DBPs in drinking water. The workshop concluded that greater collaboration of epidemiologists with water utilities and regulators should be encouraged in order to make regulatory monitoring data more useful for epidemiologic studies. Similarly, exposure classification categories in epidemiologic studies should be chosen to make results useful for regulatory or policy decision making.
Schlier, H., Principautés et dominations dans le Noueau Testament. Quaestiones disputatae 3. Ed. Desclée de Brouwer. Vol. de 80 ps. 130x201. Bruges 1968
Creators: name: Carreira, José Nunes
Publisher: name: Theologica
Year: 1969

description: Theologica, v. 4 n. 1 (1969)
Molitor, J., Grundbegriffe der Jesusüberlieferung im Lichte ihrer orientalischen Sprachgeschichte. Ed. Patmos Verlag. Vol. de 112 ps. 145x220. Düsseldorf 1968
Creators: name: Carreira, José Nunes
Publisher: name: Theologica
Year: 1969

description: Theologica, v. 4 n. 1 (1969)
Schierse, F. J., Der Brief an die Hebräer. Geistliche Schrijtlesung 18. Patmos Verlag. Vol. de 155 ps. 125x190. Düsseldorf 1968
Creators: name: Carreira, José Nunes
Publisher: name: Theologica
Year: 1969

description: Theologica, v. 4 n. 1 (1969)
Biologic Effects of Oil Fly Ash
Creators: name: Samet, James M.
name: Ghio, Andrew J.
name: Carson, Johnny L.
name: Silbajoris, Robert
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Epidemiologic studies have demonstrated increased human morbidity and mortality with elevations in the concentration of ambient air particulate matter (PM). Fugitive fly ash from the combustion of oil and residual fuel oil significantly contributes to the ambient air particle burden. Residual oil fly ash (ROFA) is remarkable in the capacity to provoke injury in experimental systems. The unique composition of this emission source particle makes it particularly useful as a surrogate for ambient air PM in studies of biologic effects testing the hypothesis that metals mediate the biologic effects of air pollution particles. A majority of the in vitro and animal model investigations support the postulate that transition metals present in ROFA (especially vanadium) participate in Fenton-like chemical reactions to produce reactive oxygen species. This is associated with tyrosine phosphorylation, nuclear factor kappa B and other transcription factor activation, induction of inflammatory mediator expression, and inflammatory lung injury. It is also evident that vanadium accounts for a significant portion of the biologic activity of ROFA. The extrapolation of this body of investigation on ROFA to the field of ambient air PM is difficult, as particles in numerous environments have such small amounts of vanadium.
Exploring and Resolving Challenges to Designing Culturally Responsive SEL Practices
Creators: name: Williams, Dwayne Donnell
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: Uncategorized

description: School-based practitioners implement social and emotional learning (SEL) programming in ways that are preplanned and curriculum-centered whereby they follow prescriptive agendas when facilitating SEL lessons while completely ignoring the cultural values, community practices, and lived experiences of students of color when building social and emotional competencies (SECs). From this perspective, SEL supports are underutilized in that they target emotional regulation and social problem-solving skills, but they fail to address social conditions that students of color experience, including social injustice, inequitable treatment, and racial trauma. While scholars call for culturally responsive approaches to SEL, pre-service and in-service school-based practitioners struggle to transfer culturally responsive theories to the classroom when designing instruction, making prepackaged, prescriptive, and preplanned curricula programs of choice. Therefore, the purpose of the current study was twofold: (1) to explore problems and contradictions seven school-based practitioners experienced concerning culturally responsive SEL (CR-SEL) and (2) to co-design an intervention aimed at resolving problems and transforming contradictions in order to construct CR-SEL activities. Cultural-historical Activity Theory (CHAT)-inspired design-based research (DBR) approaches to interventions informed the study whereby school-based practitioners problematized their SEL practices and co-designed an intervention to reimagine SEL that included their students’ cultural values, community practices, and lived experiences. Practitioners engaged in a seven-week professional development training via Zoom. I analyzed their descriptions of problems based on early meetings (meetings 1 and 2), middle meetings (meetings 3 through 5), and later meetings (meetings 6 and 7). During early meetings, practitioners engaged in a focus group, where they dedicated time describing specific problems they experienced with culturally responsive teaching in general and designing culturally responsive SEL activities in particular. During middle meetings, practitioners and I iterated a co-designed culturally responsive teaching online course to address early meeting problems. During the later meetings, practitioners used tools they co-designed during the middle meetings to construct a CR-SEL design map to use for the 2021-2022 school year. I created five categories to explain the kinds of problems practitioners described concerning CR-SEL, and I showed how collective problems manifested as primary and secondary contradictions.
Comparison of Polychlorinated Biphenyl Levels across Studies of Human Neurodevelopment
Creators: name: Heinzow, Birger
name: Brock, John W.
name: Boersma, E. Rudy
name: Charles, M. Judith
name: Rogan, Walter J.
name: Pagano, James J.
name: Weisglas-Kuperus, Nynke
name: Altshul, Larisa M.
name: Winneke, Gerhard
name: Dewailly, Éric
name: Longnecker, Matthew P.
name: Grandjean, Philippe
name: Wolff, Mary S.
name: Hertz-Picciotto, Irva
name: Ayotte, Pierre
name: Jacobson, Joseph L.
name: Jacobson, Sandra W.
name: Gladen, Beth C.
name: Korrick, Susan A.
name: Jensen, Allan A.
name: Stewart, Paul
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Polychlorinated biphenyls (PCBs) are persistent pollutants that are ubiquitous in the food chain, and detectable amounts are in the blood of almost every person in most populations that have been examined. Extensive evidence from animal studies shows that PCBs are neurotoxins, even at low doses. Interpretation of human data regarding low-level, early-life PCB exposure and subsequent neurodevelopment is problematic because levels of exposure were not similarly quantified across studies. We expressed the exposure levels from 10 studies of PCB and neurodevelopment in a uniform manner using a combination of data from original investigators, laboratory reanalyses, calculations based on published data, and expert opinion. The mainstay of our comparison was the median level of PCB 153 in maternal pregnancy serum. The median concentration of PCB 153 in the 10 studies ranged from 30 to 450 ng/g serum lipid, and the median of the 10 medians was 110 ng/g. We found that (a)) the distribution of PCB 153 exposure in most studies overlapped substantially, (b)) exposure levels in the Faroe Islands study were about 3-4-fold higher than in most other studies, and (c)) the exposure levels in the two recent U.S. studies were about one-third of those in the four earlier U.S. studies or recent Dutch, German, and northern Québec studies. Our results will facilitate a direct comparison of the findings on PCBs and neurodevelopment when they are published for all 10 studies.
Determinants of Serum Polychlorinated Biphenyls and Organochlorine Pesticides Measured in Women from the Child Health and Development Study Cohort, 1963-1967
Creators: name: Hertz-Picciotto, Irva
name: Keller, Jean A.
name: Willman, Eric
name: James, Rebecca A.
name: Charles, M. Judith
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: We examined predictors of organochlorine concentrations in serum specimens from women who were pregnant in the 1960s and participated in the Child Health and Development Study in the San Francisco Bay Area of California. That study enrolled pregnant women at the Kaiser-Permanente Medical Facilities, conducted interviews, and drew blood specimens; these specimens were centrifuged and the resulting serum specimens were frozen and placed in long-term storage. For the current investigation, organochlorines were measured by dual-column GC-electron capture detection in specimens collected in 1963-1967 from 399 pregnant women during the second and third trimesters. Using multiple linear regression models adjusted for serum lipids, we evaluated factors predicting concentrations of 11 polychlorinated biphenyl (PCB) congeners, their sum, and several pesticides and metabolites. Variables evaluated were age, race, place of birth, date of blood draw, body mass index, occupation, past residence on a farm, parity, and duration of pregnancy at blood draw. Concentrations of highly chlorinated PCBs and the sum of the PCBs increased with age. Concentrations of certain PCB congeners, as well as the sum, were significantly higher among nonwhites and increased with calendar date of blood draw. (italic)p,p(/italic) -DDT and (italic)p,p(/italic) -DDE concentrations were about 50% higher for nonwhites compared with whites and for those born in California or the southeastern United States versus elsewhere in the United States. Higher body mass index was associated with lower concentrations of several PCBs and (italic)p,p(/italic) -DDE but with higher heptachlor epoxide and DDT levels. The increase in use of PCBs during the 1960s is apparently detectable as increasing concentrations in maternal sera between 1963 and 1967. Marked racial and regional differences in serum pesticide levels were likely caused by geographic variation in previous agricultural and vector-control uses. The relationship to body mass index appears to be complex.
Efficient Privacy-Preserved Processing of Multimodal Data for Vehicular Traffic Analysis
Creators: name: Mohammady, Meisam
name: Arablouei, Reza
Publisher: name: arXiv
Year: 2023
Subjects: subject: Cryptography and Security (cs.CR)
subject: Systems and Control (eess.SY)
subject: Statistics Theory (math.ST)
subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Mathematics

description: We estimate vehicular traffic states from multimodal data collected by single-loop detectors while preserving the privacy of the individual vehicles contributing to the data. To this end, we propose a novel hybrid differential privacy (DP) approach that utilizes minimal randomization to preserve privacy by taking advantage of the relevant traffic state dynamics and the concept of DP sensitivity. Through theoretical analysis and experiments with real-world data, we show that the proposed approach significantly outperforms the related baseline non-private and private approaches in terms of accuracy and privacy preservation.
Essays on Competition and Innovation: Empirical Investigations of Product Recalls and Private Labels
Creators: name: Matsumoto, Kohei
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: Uncategorized

description: This dissertation focuses on how competition influences firms’ innovation activities. Although research suggests that competition generally motivates firms to innovate, innovation as a response to competition may not always materialize because innovation is risky and resource intensive. Nuances of the competition-innovation relationship are different depending on specific contexts. This dissertation examines two unique contexts where competition may not lead to increased innovation: product recalls and private labels. Essay 1 of this dissertation focuses on product recalls. While the competitive response literature predicts that firms intensify innovation when their competitors experience product recalls and are thus vulnerable to competitive actions, I apply vicarious learning theory and show that competitors’ product recalls in fact reduce the focal firm’s new product introductions because the focal firm learns from competitors’ product recalls, which shifts its resources from new product development to product safety. Essay 2 focuses on private label products. While researchers have suggested that a potential strategy for national brand manufacturers to compete with private labels is to intensify innovation to differentiate their products, I apply threat-rigidity theory and show that the growth of private labels increases manufacturers’ exploitative innovation, but not explorative innovation. This is because the threat of private labels causes manufacturers to act rigidity, leading them to avoid taking risks but rely on well-learned actions. In both essays, I identify conditions that strengthen or weaken the above-mentioned effects. Firms’ understanding of their competitive positions and implementation of competitive actions are influenced by how they view their competitors as well as customers. My focus on competitors complements the marketing literature’s traditional emphasis on customers in firm innovation.
Learning Analytics: A Survey
Creators: name: Keshavamurthy, Usha
name: Guruprasad, H. S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Databases (cs.DB)
subject: FOS: Computer and information sciences
subject: E.0

description: Learning analytics is a research topic that is gaining increasing popularity in recent time. It analyzes the learning data available in order to make aware or improvise the process itself and/or the outcome such as student performance. In this survey paper, we look at the recent research work that has been conducted around learning analytics, framework and integrated models, and application of various models and data mining techniques to identify students at risk and to predict student performance.
J. N. L. Myres and Barbara Green, The Anglo-Saxon Cemeteries of Caistor-by-Norwich and Markshall, Norfolk
Creators: name: Schmid, Peter
Publisher: name: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts
Year: 2023

description: Rezension zu: J. N. L. Myres and Barbara Green, The Anglo-Saxon Cemeteries of Caistor-by-Norwich and Markshall, Norfolk. Reports of the Research Committee of the Society of Antiquaries of London, No. XXX. Published by The Society of Antiquaries of London, 1973. XX und 267 Seiten, 71 Abbildungen, 24 Tafeln und 3 Karten.
description: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts, Bd. 54 Nr. 2 (1976)
Facebook Data Shield: Increasing Awareness and Control over Data used by Newsfeed-Generating Algorithms
Creators: name: Sinsel, Jules
name: Jansen, Anniek
name: Colombo, Sara
Publisher: name: arXiv
Year: 2023
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: Social media platforms newsfeeds are generated by AI algorithms, which select and order posts based on user data. However, users are often unaware of what data is collected and employed for this aim, neither can they control it. To open up discussions on what data users are willing to feed the newsfeed algorithm with, we created the Facebook Data Shield, a human-size interactive installation where users can see and control what type of data is collected. By pressing buttons, data categories and/or data variables can be (de)activated. An outer rim with lights gives feedback to users about the level of personalization of the resulting newsfeed. We performed a preliminary study to get insights into what data users are willing to share, their preferred level of control, and the effect of such an installation on users' awareness. Based on our findings, we discuss implications for design and future work.