cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 7: of Similarity of the dog and human gut microbiomes in gene content and response to diet
Creators: name: Coelho, Luis
name: Kultima, Jens
name: Costea, Paul
name: Fournier, Coralie
name: Pan, Yuanlong
name: Czarnecki-Maulden, Gail
name: Hayward, Matthew
name: Forslund, Sofia
name: Schmidt, Thomas
name: Descombes, Patrick
name: Jackson, Janet
name: Li, Qinghong
name: Bork, Peer
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Figure S1. Gene accumulation curve for dog, pig, mouse, and human gut microbiomes. (PDF 1676Â kb)
title: Reversible photoregulation of cell-cell adhesions with opto-E-cadherin
Creators: name: Nzigou Mombo, Brice
name: Bijonowski, Brent M.
name: Raab, Christopher A.
name: Niland, Stephan
name: Brockhaus, Katrin
name: Müller, Marcus
name: Eble, Johannes A.
name: Wegner, Seraphine V.
Publisher: name: University of Muenster, Institutional Repository MIAMI
Year: 2025
Subjects: subject: 572 Biochemistry

description: E-cadherin-based cell-cell adhesions are dynamically and locally regulated in many essential processes, including embryogenesis, wound healing and tissue organization, with dysregulation manifesting as tumorigenesis and metastasis. However, the lack of tools that would provide control of the high spatiotemporal precision observed with E-cadherin adhesions hampers investigation of the underlying mechanisms. Here, we present an optogenetic tool, opto-E-cadherin, that allows reversible control of E-cadherin-mediated cell-cell adhesions with blue light. With opto-E-cadherin, functionally essential calcium binding is photoregulated such that cells expressing opto-E-cadherin at their surface adhere to each other in the dark but not upon illumination. Consequently, opto-E-cadherin provides remote control over multicellular aggregation, E-cadherin-associated intracellular signalling and F-actin organization in 2D and 3D cell cultures. Opto-E-cadherin also allows switching of multicellular behaviour between single and collective cell migration, as well as of cell invasiveness in vitro and in vivo. Overall, opto-E-cadherin is a powerful optogenetic tool capable of controlling cell-cell adhesions at the molecular, cellular and behavioural level that opens up perspectives for the study of dynamics and spatiotemporal control of E-cadherin in biological processes.
description: Finanziert über die DEAL-Vereinbarung mit Wiley, Springer oder Elsevier 2019–2023.
Additional file 8: of Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities
Creators: name: Garrett, Matthew
name: Sperry, Jantzen
name: Braas, Daniel
name: Yan, Weihong
name: Le, Thuc
name: Mottahedeh, Jack
name: Ludwig, Kirsten
name: Eskin, Ascia
name: Qin, Yue
name: Levy, Rachelle
name: Breunig, Joshua
name: Pajonk, Frank
name: Graeber, Thomas
name: Radu, Caius
name: Christofk, Heather
name: Prins, Robert
name: Lai, Albert
name: Liau, Linda
name: Coppola, Giovanni
name: Kornblum, Harley
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: IDH1 mutant overexpression leads to high levels of 2-HG and the c227 inhibitor is an effective inhibitor of 2-HG formation. IDH wildtype gliomaspheres transduced with the IDH1 mutant enzyme (308 + IDH1mut) and endogenous IDH1 mutant cells treated with 5 μM c227 inhibitor (213 + c227) for 24 h are compared to their respective controls (308 and 213) for 2-HG levels as determined by LC-MS. Data represent the means ± SEM of three replicates per condition. (PDF 22 kb)
First Life, un social network civico, al servizio della cooperazione internazionale
Creators: name: Cerutti, Monica
name: Boella, Guido
name: Dansero, Egidio
name: Mosca, Marta
name: Rondelli, Alberto
name: Sonzogni, Chiara
name: Viano, Cristina
Publisher: name: JUNCO | Journal of UNiversities and international development COoperation
Year: 2024

description: FirstLife è il social network civico sviluppato dal Dipartimento di Informatica dell’Università di Torino per la creazione, la condivisione e lo scambio di informazioni tra tutti gli attori privati e pubblici coinvolti in iniziative territoriali civiche, sociali, commerciali e ricreative e nella gestione dei servizi locali, a diverse scale che vanno dalla piazza alla città e oltre. Si tratta di una piattaforma di crowdsourcing basata su una mappa interattiva in cui i contenuti riguardano le attività e i progetti associati ai luoghi dove si può interagire con gli altri utenti partecipando a discussioni, gruppi tematici ed eventi.
description: JUNCO | Journal of UNiversities and international development COoperation, Vol. 5 No. 2 (2021): ICT, sviluppo e cooperazione: ricerca visuale e partecipazione
Microscopic-SEM-BSE images of investigated metabasites. Using palaeomagnetic and isotopic data to investigate late to post-Caledonian tectonothermal processes within the Western Terrane of Svalbard
Creators: name: Michalski, Krzysztof
name: Manby, Geoffrey
name: Nejbert, Krzysztof
name: Domańska-Siuda, Justyna
name: Burzyński, Mariusz
Publisher: name: Geological Society of London
Year: 2017
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: Supplementary data 5 - Microscopic-SEM-BSE images of investigated metabasites
Additional file 8: of Similarity of the dog and human gut microbiomes in gene content and response to diet
Creators: name: Coelho, Luis
name: Kultima, Jens
name: Costea, Paul
name: Fournier, Coralie
name: Pan, Yuanlong
name: Czarnecki-Maulden, Gail
name: Hayward, Matthew
name: Forslund, Sofia
name: Schmidt, Thomas
name: Descombes, Patrick
name: Jackson, Janet
name: Li, Qinghong
name: Bork, Peer
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Figure S2. (a) Distance between samples from multiple hosts (and from two separate human cohorts as a control) measured by abundance-weighted Jaccard distance (b) overlap in detected (named) genera (genera with prevalence >â 1%) [number of genera]. (PDF 49Â kb)
Additional file 9: of Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities
Creators: name: Garrett, Matthew
name: Sperry, Jantzen
name: Braas, Daniel
name: Yan, Weihong
name: Le, Thuc
name: Mottahedeh, Jack
name: Ludwig, Kirsten
name: Eskin, Ascia
name: Qin, Yue
name: Levy, Rachelle
name: Breunig, Joshua
name: Pajonk, Frank
name: Graeber, Thomas
name: Radu, Caius
name: Christofk, Heather
name: Prins, Robert
name: Lai, Albert
name: Liau, Linda
name: Coppola, Giovanni
name: Kornblum, Harley
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: IDH1 mutant enzyme does not affect glucose labeling of nucleotide precursors. Cells were treated and analyzed as described for Supporting Figure S4 in order to determine the percent labeling of nucleotide precursors. There is no significant difference when comparing IDH1 mutant overexpression or endogenous mutant inhibition to their respective controls. (PDF 64Â kb)
Structure–property relationships in twist-bend nematogens: the influence of terminal groups
Creators: name: Abberley, Jordan P.
name: Jansze, Suzanne M.
name: Walker, Rebecca
name: Paterson, Daniel A.
name: Henderson, Peter A.
name: Marcelis, Antonius T. M.
name: Storey, John M. D.
name: Imrie, Corrie T.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Plant Biology
subject: FOS: Biological sciences

description: The synthesis and characterisation of a range of non-symmetric liquid crystal dimers designed to exhibit the twist-bend nematic phase is reported. Beginning with 1-(4-cyanobiphenyl-4′-yloxy)-6-(4-cyanobiphenyl-4′-yl) hexane, each nitrile group is exchanged systematically for a methoxy group. The behaviour of these dimers is interpreted in terms of their bent shape being the predominant driving force for the formation of the twist-bend nematic phase, and the small differences between the twist-bend nematic–nematic transition temperatures are attributed to the differences between the interaction strength parameters of the mesogenic units. The 4-alkyloxyphenyl 4-[6-(4′-cyanobiphenyl-4-yl)hexyloxy]benzoates with ethyl, butyl, hexyl and octyl chains show the twist-bend nematic phase, whereas the corresponding 4-alkyloxyphenyl 4-[5-(4′-cyanobiphenyl-4-yloxy)pentyloxy]benzoates do not. This difference in behaviour is attributed to the more bent structure of the former. Increasing the terminal chain length initially decreases the twist-bend nematic–nematic transition temperature and this suggests that the chain disrupts the interactions between the mesogenic units. Subsequent increases in chain length have a smaller effect suggesting that the chain can be accommodated within an intercalated arrangement. The transitional behaviour of 1-(4-cyanobiphenyl-4′-yloxy)-6-(4-butyloxybiphenyl-4′-yl) hexane is compared to that of 1-(4-cyanobiphenyl-4′-yloxy)-6-(4-((S)-2-methyl)butyloxybiphenyl-4′-yl) hexane, and it is shown that chain branching strongly destabilises the twist-bend nematic phase. This is attributed to difficulties associated with packing the dimers.
Additional file 9: of Similarity of the dog and human gut microbiomes in gene content and response to diet
Creators: name: Coelho, Luis
name: Kultima, Jens
name: Costea, Paul
name: Fournier, Coralie
name: Pan, Yuanlong
name: Czarnecki-Maulden, Gail
name: Hayward, Matthew
name: Forslund, Sofia
name: Schmidt, Thomas
name: Descombes, Patrick
name: Jackson, Janet
name: Li, Qinghong
name: Bork, Peer
Publisher: name: figshare
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Figure S3. Mapping rates of human reads to the gut gene catalogs of the four mammalian hosts considered (humans, mice, dogs, and pigs). (PDF 1848Â kb)
Non medical factors influencing the admission to intensive care at the end of life
Creators: name: Escher, Monica
Publisher: name: Université de Genève
Year: 2015
Subjects: info:eu-repo/classification/ddc/617
Intensive care
End of life
Decision making

description: Non medical factors may significantly influence medical decisions in situations of great uncertainty. Triage of a seriously ill patient or a frail elderly to intensive care represents one such situation. Uncertainty as to the patient outcome, limited opportunity to involve him in the decision, time-pressured circumstances and scarcity of the health care resource make the task especially complex. Variability in the provision of life-sustaining treatments at the end of life was observed. Non medical factors were associated with the ICU admission decision. They are organisational, patient-related and physician-related. Physicians' reasons for ICU admission or refusal at the end of life, and how influential non medical factors are on the decision remain unclear. Facilitating triage and ensuring a fair and transparent decision making process are important to improve patient end of life care and to optimize the use of ICU health care resource. Advance care planning and a better understanding of the ICU admission decision process are two promising areas for research.
Periostin a bone matrix protein involved in bone anabolism, implication in bone health from basic to clinical research
Creators: name: Bonnet, Nicolas
Publisher: name: Université de Genève
Year: 2015
Subjects: info:eu-repo/classification/ddc/616
Bone formation
Periostin
Osteocyte
Exercise
Parathyroid hormone

description: Osteoporosis is a major chronic disease of aging, causing fractures, pain and disability. This skeletal fragility results from excessive bone catabolism in the face of declining bone anabolism. Whereas anti-resorptive drugs are well developed, only parathyroid hormone is capable to rebuild the altered bone structure. Hence, by gaining novel insights in the anabolic molecular processes of the matricellular protein called periostin, we hope to delineate new therapeutic targets to restore bone strength. By virtue of its signaling pathway and its spatial localization in osteocyte and osteoblast of the periosteal surface of cortical bone, we demonstrate its important role in the skeletal adaptations, and we are on the verge of revealing molecular mechanisms by which periostin regulates bone formation. Moreover, by its multiple facets, we highlight that periostin is a promising tool to improved therapeutic strategies and/or diagnosis of bone fragility through its association with cortical bone microarchitecture.
The role of polymerase chain reaction in the diagnosis of early syphilis
Creators: name: Gayet-Ageron, Angèle
Publisher: name: Université de Genève
Year: 2015
Subjects: info:eu-repo/classification/ddc/613
Syphilis
Polymerase chain reaction
Sexually transmitted infection
Diagnostic performance
Sensitivity
Specificity

description: Syphilis is a sexually-transmitted bacterial infection that re-emerged in the early 2000s. The treatment of syphilis is easy, cheap, and well tolerated, but its diagnosis remains challenging. In particular, it may be missed in the early phase of the disease and then evolve to more advanced stages, or provide a portal of entry for human immunodeficiency virus. Since the early 1990s, Treponema pallidum polymerase chain reaction (Tp-PCR) has been investigated as a complementary diagnostic tool. We first assessed the diagnostic performance of Tp-PCR in various biological specimens and syphilis stages and demonstrated Tp-PCR performed better in ulcers or skin lesions. We secondly conducted a multicentre prospective clinical study to evaluate the accuracy of Tp-PCR compared to darkfield microscopy in ulcers and we concluded that Tp-PCR could even replace darkfield microscopy in routine screening. Finally, we showed that the two current genes targeted for Tp-PCR could be univocally used.
MOESM1 of Characterisation of an efficient atrazine-degrading bacterium, Arthrobacter sp. ZXY-2: an attempt to lay the foundation for potential bioaugmentation applications
Creators: name: Zhao, Xinyue
name: Wang, Li
name: Ma, Fang
name: Yang, Jixian
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Figure S1. Time courses of atrazine degradation of strain ZXY-2 containing different initial atrazine concentrations. Figure S2. Atrazine-degrading gene amplification of Arthrobacter sp. ZXY-2. Table S1. Comparison of degradation rates with reported atrazine-degrading strains. Table S2. Sequence of the primer pairs used in PCR study. Table S3. The detail information of three identified atzB proteins in the whole genome nucleotide sequence.
Chromium(III) complexes bearing bis(benzotriazolyl)pyridine ligands: synthesis, characterization and ethylene polymerization behavior
Creators: name: Hurtado, John
name: Nuñez-Dallos, Nelson
name: Movilla, Santiago
name: Miscione, Gian Pietro
name: Peoples, Brian C.
name: Rojas, René
name: Valderrama, Mauricio
name: Fröhlich, Roland
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Computational Biology

description: Reaction of benzotriazole with 2,6-bis(bromomethyl)pyridine and 2,6-pyridinedicarbonyl dichloride yields the tridentate ligands 2,6-bis(benzotriazol-1-ylmethyl)pyridine (1) and 2,6-bis(benzotriazol-1-ylcarbonyl) pyridine (2). The molecular structures of the ligands were determined by single-crystal X-ray diffraction. These ligands react with CrCl3(THF)3 in THF to form neutral complexes, [CrCl3{2,6-bis(benzotriazolyl)pyridine-N,N,N}] (3, 4), which are isolated in high yields as air stable green solids and characterized by mass spectra (ESI), FTIR spectroscopy, UV–Visible, thermogravimetric analysis (TGA), and magnetic measurements. After reaction with methylaluminoxane (MAO), the chromium(III) complexes are active in the polymerization of ethylene showing a bimodal molecular weight distribution. A DFT computational investigation of the polymerization reaction mechanism shows that the most likely reaction pathway originates from the mer configuration when the spacer is CH2 (complex 3) and from the fac configuration when the spacer is CO (complex 4).
Specific clusters of fatty acids (FA) across multiple serum lipid fractions underlie pathophysiological features of type 2 diabetes in the Canadian PROMISE cohort
Creators: name: Johnston, Luke
name: Liu, Zhen
name: Retnakaran, Ravi
name: Harris, Stewart B.
name: P. Bazinet, Richard
name: J. Hanley, Anthony
Publisher: name: figshare
Year: 2018
Subjects: classificationCode: 420299
subject: Epidemiology not elsewhere classified
classificationCode: 320220
subject: Pathology (excl. oral pathology)

description: Poster presented at the European Diabetes Epidemiology Group Meeting in Elsinore, Denmark from April 21-24, 2018.
Structural studies of the cadmium(II) chloride / sparteine system
Creators: name: Sigrist, Lukas
name: Schwenk, Rino
name: Czarniecki, Barbara
name: Togni, Antonio
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Inorganic Chemistry
subject: Computational Biology

description: The reaction of dichlorocadmium(II) and (-)-sparteine (sp) provides two products, [CdCl2(sp)]) (1) and (Hsp)3[Cd2Cl7] (2). The latter represents one of the rare known examples exhibiting an isolated Cd2Cl73− trianion. Both products are formed in the same reaction mixture and single crystals of one of the two products can be obtained selectively by crystallization depending on the co-solvent. The formation and structural characterization of (H2sp)[CdCl4] (3) is also reported, crystallizing with either dichloromethane (3a) or water (3b) as guest molecules.
Design of potent fluoro-substituted chalcones as antimicrobial agents
Creators: name: Burmaoglu, Serdar
name: Oztekin Algul
name: Gobek, Arzu
name: Anil, Derya Aktas
name: Ulger, Mahmut
name: Busra Gul Erturk
name: Kaplan, Engin
name: Dogen, Aylin
name: Aslan, Gönül
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Owing to ever-increasing bacterial and fungal drug resistance, we attempted to develop novel antitubercular and antimicrobial agents. For this purpose, we developed some new fluorine-substituted chalcone analogs (3, 4, 9–15, and 20–23) using a structure–activity relationship approach. Target compounds were evaluated for their antitubercular efficacy against Mycobacterium tuberculosis H37Rv and antimicrobial activity against five common pathogenic bacterial and three common fungal strains. Three derivatives (3, 9, and 10) displayed significant antitubercular activity with IC50 values of ≤16,760. Compounds derived from trimethoxy substituent scaffolds with monofluoro substitution on the B ring of the chalcone structure exhibited superior inhibition activity compared to corresponding hydroxy analogs. In terms of antimicrobial activity, most compounds (3, 9, 12–14, and 23) exhibited moderate to potent activity against the bacteria, and the antifungal activities of compounds 3, 13, 15, 20, and 22 were comparable to those of reference drugs ampicillin and fluconazole.
L'optimisation du support nutritionnel pour le patient de soins intensifs
Creators: name: Heidegger, Claudia Paula
Publisher: name: Université de Genève
Year: 2014
Subjects: info:eu-repo/classification/ddc/617

description: The critically ill patient undergoes an obligatory hypercatabolic phase and is at risk to an increasing nutrional deficit during the ICU length of stay. Exclusive enteral nutrition (EN)results in underfeeding proven to be associated with higher morbidity and mortality in the critically ill. Adequate energy and protein targets often cannot be obtained before 1 week with EN alone. We have hypothesized that supplemental parenteral nutrition (SPN) combined with EN would be an effective alternative to achieve the 100% energy target from day 4, when EN support was less than 60% by day 3. The results of such a combined nutrition support are recently published in the Swiss “SPN study” and showed clinical outcome benefits in critically ill patients with less nosocomial infections by achieving 100 % energy goals from admission day 4 to day 8. The constantly changing energy requirements during critical illness should be most accurately adapted by indirect calorimeter measurements. Indeed close nutritional and metabolic monitoring together with consequent adjustments of nutritional support improves clinical outcome of critically ill patients. In contrary, inadequate parenteral feeding in ICU patients without real indication worsens clinical outcome. With a combined nutrition support concept not only the best energy requirements but also optimized protein targets can be promoted. Whether the determination of the best protein target for the critically ill and protein support adaptation during the acute and post-acute phase of critical illness provides additional overall outcome benefits has to be ascertained in further studies. Further research should focus more on studies of more personalized nutritional management and early physical rehabilitation programs according to the individual specific needs of the ICU patient.
Molecular Bases for Combinatorial Treatment Strategies in Patients with KRAS Mutant Lung Adenocarcinoma and Squamous Cell Lung Carcinoma
Creators: name: Lazzari, Chiara
name: Verlicchi, Alberto
name: Gkountakos, Anastasios
name: Pilotto, Sara
name: Santarpia, Mariacarmela
name: Chaib, Imane
name: Serrano, Jose Luis Ramirez
name: Viteri, Santiago
name: Morales-Espinosa, Daniela
name: Dazzi, Claudio
name: de Marinis, Filippo
name: Cao, Peng
name: Karachaliou, Niki
name: Rosell, Rafael
Publisher: name: Adis Journals
Year: 2018
Subjects: Medicine
Respiratory Diseases

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Chromium(III) complexes bearing bis(benzotriazolyl)pyridine ligands: Synthesis, characterization and ethylene polymerization behavior
Creators: name: Hurtado, John
name: Nuñez-Dallos, Nelson
name: Movilla, Santiago
name: Miscione, Gian Pietro
name: Peoples, Brian C.
name: Rojas, René
name: Valderrama, Mauricio
name: Fröhlich, Roland
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Computational Biology

description: Reaction of benzotriazole with 2,6-bis(bromomethyl)pyridine and 2,6-pyridinedicarbonyl dichloride yield the tridentate ligands 2,6-bis(benzotriazol-1-ylmethyl)pyridine (1) and 2,6-bis(benzotriazol-1-ylcarbonyl) pyridine (2). The molecular structures of the ligands were determined by single-crystal X-ray diffraction. These ligands react with CrCl3(THF)3 in THF to form neutral complexes, [CrCl3{2,6-bis(benzotriazolyl)pyridine-N,N,N}] (3, 4), which are isolated in high yields as air stable green solids and characterized by mass spectra (ESI), FTIR spectroscopy, UV-visible, thermogravimetric analysis (TGA) and magnetic measurements. After reaction with methylaluminoxane (MAO) the chromium(III) complexes are active in the polymerization of ethylene showing a bimodal molecular weight distribution. A DFT computational investigation of the polymerization reaction mechanism shows that the most likely reaction pathway originates from the mer configuration when the spacer is CH2 (complex 3) and from the fac configuration when the spacer is CO (complex 4).
Multimodal and multidisciplinary strategies in the prevention of healthcare-associated infections – the example of catheter-associated bloodstream infections
Creators: name: Zingg, Walter
Publisher: name: Université de Genève
Year: 2015
Subjects: info:eu-repo/classification/ddc/616
Healthcare-associated infection
Bloodstream infection
Central line-associated bloodstream infection
Infection control
Prevention
Multimodal
Multidisciplinary
Implementation

description: Healthcare-associated infections (HAIs) affect millions of patients worldwide each year. Bloodstream infections represent about 12% of all HAI. Most healthcare-associated bloodstream infections are catheter-associated and are largely preventable. This was evidenced in a recent large systematic review about organisation and structure in infection prevention and control. Behavioural change interventions are complex and such programmes must follow a multimodal strategy developed by multidisciplinary teams, and taking into account local conditions. Multimodal strategies are a combination of technology and best practice, which are delivered by different “modes” such as lectures, visual reminders, simulation training, or any other original idea of dissemination. Two projects summarized here are examples of successful multimodal prevention strategies. They promoted comprehensive best practice procedures and both used different modes and professions to provide education and training. The major challenge of multimodal strategies is “implementation” and more research must be invested on this aspect in the future.
MAE-6226: Aerodynamics Course Syllabus
Creators: name: Barba, Lorena A.
Publisher: name: figshare
Year: 2017
Subjects: subject: Mechanical Engineering
subject: FOS: Mechanical engineering

description: MAE-6226 (Aerodynamics) Course Syllabus, as taught at the George Washington University in Spring 2017.
GW University Bulletin 2016-2017: http://bulletin.gwu.edu/search/?P=MAE+6226
The equations for Taguchi experiment design and mechanism study as well as detailed analysis data from Fe3O4 nanoparticle-coated mushroom source biomaterial for Cr(VI) polluted liquid treatment and mechanism research.
Creators: name: Wang, Can
name: Liu, Huakang
name: Liu, Zizhao
name: Gao, Yufeng
name: Wu, Bin
name: Xu, Heng
Publisher: name: The Royal Society
Year: 2018

description: STable 1 Thecy STable 2 Models equations of biosorption isotherms, kinetics and thermodynamic studies STable 3. S/N ratio for each factor in each level STable 4. The average of removal efficiency results of a certain factor in the kth level (¯R_k^A,〖 ¯R〗_k^B, ¯R_k^C, ¯R_k^D) and the average of total removal efficiency (¯R_T).
The equations for Taguchi experiment design and mechanism study as well as detailed analysis data from Fe3O4 nanoparticle-coated mushroom source biomaterial for Cr(VI) polluted liquid treatment and mechanism research
Creators: name: Wang, Can
name: Liu, Huakang
name: Liu, Zizhao
name: Gao, Yufeng
name: Wu, Bin
name: Xu, Heng
Publisher: name: The Royal Society
Year: 2018

description: STable 1 Thecy STable 2 Models equations of biosorption isotherms, kinetics and thermodynamic studies STable 3. S/N ratio for each factor in each level STable 4. The average of removal efficiency results of a certain factor in the kth level (¯R_k^A,〖 ¯R〗_k^B, ¯R_k^C, ¯R_k^D) and the average of total removal efficiency (¯R_T).
A Python Program Analysis Infrastructure to Facilitate Better Data Processing
Creators: name: Zhang, Xiangyu
name: Zhai, Juan
Publisher: name: figshare
Year: 2018
Subjects: classificationCode: 461299
subject: Software engineering not elsewhere classified

description: A powerful Python analysis infrastructure to support the three most popular kinds of analyses: static, dynamic and symbolic, just like LLVM for C/C++ and KLEE for C. This infrastructure will enable many researches across multiple CISE areas such as software engineering, programming languages, machine learning, AI and data science. With Python being the number one language in ML and data science, the infrastructure will stimulate exciting new research in improving data processing effectiveness, reliability, stability, and efficiency.
Using Robust Statistical Methodology to Evaluate the Cost Performance of Project Delivery Systems: A Case Study of Horizontal Construction
Creators: name: Dares Charoenphol
name: Stuban, Steven M. F.
name: Dever, Jason R.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: The objective of this study is to demonstrate the application of the bootstrapping M-estimator (a robust analysis of variance [ANOVA]) to test the null hypothesis of means equality among the cost performance of the three project delivery systems (PDS). A statistical planned contrast methodology is utilized after the robust ANOVA analysis to further determine where the differences of the means lie. The results of this research concluded that traditional PDS (Design-Bid-Build [DBB]) outperformed the two innovative PDS (Design-Build [DB] and Construction Manager/General Contractor [CMGC]), DBB and CMGC outperformed DB, and DBB outperformed CMGC, for the Cost Growth and the Change Order Cost Factor performance. These findings can help decision makers/owners make an informed decision regarding cost related aspects when choosing PDS for their projects. Though the case study of this research is based on the sample data obtained from the construction industry, the same methodology and statistical process can be applied to other industries and factors/variables of interest when the study sample data are unbalanced and the normality and homogeneity of variance assumptions are violated.
Oxidative amidation of benzyl alcohols with amino acid esters mediated by N-hydroxysuccinimide/phenyliodine diacetate
Creators: name: Mandipogula Mahesh
name: Veladi Panduranga
name: Girish Prabhu
name: Roopesh Kumar L
name: P. Venkata Ramana
name: Vommina V. Sureshbabu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: A simple protocol involving metal-free oxidative amidation of benzyl alcohols with amino acid esters has been presented. The amidation proceeds in a radical pathway unlike in conventional metal-mediated extrusion of dihydrogen. The method is advantageous in terms of metal-free conditions, nonexpensive commercial starting substrates. Also various substituents in the starting materials are tolerated and sterically hindered amino acid side chains could provide good yields of amide products.
Presentation Skills and Strategies
Creators: name: Albert, Paul
Publisher: name: figshare
Year: 2017
Subjects: subject: 120307 Visual Communication Design (incl. Graphic Design)
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: Thoughts on what makes for a great presentation. Includes the importance of a strong thesis, speaking style, and visual considerations.
A Python Program Analysis Infrastructure to Facilitate Better Data Processing
Creators: name: Zhang, Xiangyu
name: Zhai, Juan
Publisher: name: figshare
Year: 2018
Subjects: classificationCode: 461299
subject: Software engineering not elsewhere classified

description: p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px 'Helvetica Neue'; -webkit-text-stroke: #000000}
span.s1 {font-kerning: none}

A powerful Python analysis infrastructure to support the three most popular kinds of analyses: static, dynamic and symbolic, just like LLVM for C/C++ and KLEE for C. This infrastructure will enable many researches across multiple CISE areas such as software engineering, programming languages, machine learning, AI and data science. With Python being the number one language in ML and data science, the infrastructure will stimulate exciting new research in improving data processing effectiveness, reliability, stability, and efficiency.
A Python Program Analysis Infrastructure to Facilitate Better Data ProcessingUntitled Item
Creators: name: Zhang, Xiangyu
name: Zhai, Juan
Publisher: name: figshare
Year: 2018
Subjects: classificationCode: 461299
subject: Software engineering not elsewhere classified

description: p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px 'Helvetica Neue'; -webkit-text-stroke: #000000}
span.s1 {font-kerning: none}

A powerful Python analysis infrastructure to support the three most popular kinds of analyses: static, dynamic and symbolic, just like LLVM for C/C++ and KLEE for C. This infrastructure will enable many researches across multiple CISE areas such as software engineering, programming languages, machine learning, AI and data science. With Python being the number one language in ML and data science, the infrastructure will stimulate exciting new research in improving data processing effectiveness, reliability, stability, and efficiency.
title: A study on the space composition designed by Stanisław Niemczyk in the context of evolving religiousness and spirituality
Creators: name: Tomczak, Joanna
Publisher: name: Conference Proceedings XXIX International Seminar on Urban Form ISUF 2022 Urban Redevelopment and Revitalisation A Multidisciplinary Perspective/Lodz University of Technology Press
Year: 2023
Subjects: Sacrum, City, Niemczyk, Space Syntax, Justified Plan Graph.

description: The proposed paper explores whether the traditional religious space can meet the needs of individual religiousness. The primary hypothesis assumes that the appropriate sequence of urban interiors, spatial boundaries, and transition points can be conducive to religious feelings. The research concerns architectural projects of Stanisław Niemczyk which combine spatial complexity along with a common impression of the prevailing religious atmosphere. The applied graph-based method intentionally ignores the architecture of the temple and concentrates particularly on spatial aspects. At first, individual units of space are distinguished, so that connections between them can be examined. The use of geometric simplification of space makes it easier to investigate space complexity, which appears to be overlooked in both architectural and urban analyses. However, this aspect seems to be crucial in terms of space that is related to spirituality.
Additional file 1: of Intraspecific variation of residual heterozygosity and its utility for quantitative genetic studies in maize
Creators: name: Liu, Nannan
name: Liu, Jianxiao
name: Li, Wenqiang
name: Pan, Qingchun
name: Liu, Jie
name: Yang, Xiaohong
name: Yan, Jianbing
name: Xiao, Yingjie
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Figure S1. Distribution of RHR in each line in 12 populations and the RH length for all RH intervals. (PDF 179Â kb)
Additional file 3: of Intraspecific variation of residual heterozygosity and its utility for quantitative genetic studies in maize
Creators: name: Liu, Nannan
name: Liu, Jianxiao
name: Li, Wenqiang
name: Pan, Qingchun
name: Liu, Jie
name: Yang, Xiaohong
name: Yan, Jianbing
name: Xiao, Yingjie
Publisher: name: figshare
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Figure S2. Distribution of residual heterozygosity in the whole genome across 6 populations. (PDF 130Â kb)
Oxidative Amidation of Benzyl Alcohols with Amino Acid Esters Mediated by N-hydroxysuccinimide/phenyliodine Diacetate
Creators: name: Mandipogula Mahesh
name: Veladi Panduranga
name: Girish Prabhu
name: Roopesh Kumar L
name: P. Venkata Ramana
name: Vommina V. Sureshbabu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: A simple protocol involving metal free oxidative amidation of benzyl alcohols with amino acid esters has been presented. The amidation proceeds in a radical pathway unlike in conventional metal mediated extrusion of dihydrogen. The method is advantageous in terms of metal free conditions, non expensive commercial starting substrates. Also various substituents in the starting materials are tolerated and sterically hindered amino acid side chains could provide good yields of amide products.
Additional file 4: of Intraspecific variation of residual heterozygosity and its utility for quantitative genetic studies in maize
Creators: name: Liu, Nannan
name: Liu, Jianxiao
name: Li, Wenqiang
name: Pan, Qingchun
name: Liu, Jie
name: Yang, Xiaohong
name: Yan, Jianbing
name: Xiao, Yingjie
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Figure S3. Enrichment analysis of paralogous genes and repetitive sequences within RH hotspot regions. (PDF 201Â kb)
EdTech and Girls Education in Low- and Middle-Income Countries: Which Intervention Types Have the Greatest Impact on Learning Outcomes for Girls?
Creators: name: Jordan, K
name: Myers, C
Publisher: name: ACM
Year: 2022
Subjects: 4404 Development Studies
39 Education
44 Human Society
Behavioral and Social Science
3.1 Primary prevention interventions to modify behaviours or promote wellbeing
Mental health
4 Quality Education

description: Gender-based inequality in access to education is an issue of global concern. The use of educational technology is often cited as a potential way to help close educational gaps and promote girls’ education. However, the existing evidence base in relation to girls’ learning outcomes when using educational technology in low-income countries is limited. The evidence base was recently boosted by a study in which findings from classic educational development studies were revisited and disaggregated by gender [7]. In this paper, we present a secondary analysis of this dataset, focusing specifically on the educational technology-focused interventions, and sourcing additional data. The analysis comprises 35 interventions, reported across 15 publications, published between 2003 and 2019.We discuss the relative efficacy of different types of educational technology interventions by comparing effect sizes of learning outcomes for girls. The findings suggest that interventions which focus on distributing hardware alone have mixed - and sometimes negative - effects on learning outcomes for girls. The impact of software-focused interventions is more positive, particularly personalised learning applications. Furthermore, we consider characteristics of the studies included in the analysis, and identify gaps in the literature which will help shape research in this field in the future.
Variability in patients with unilateral cleft lip and palate
Creators: name: Antonarakis, Gregory
Publisher: name: Université de Genève
Year: 2015
Subjects: info:eu-repo/classification/ddc/617.6

description: Patients with complete unilateral cleft lip and palate (UCLP) display considerable variability in clinical presentation. This variability relates to presentation at birth, later observed dento-alveolar and skeletal craniofacial deficiencies, response to treatment, and post-treatment stability. Possible factors affecting later observed variability are genetics, function, and iatrogenic influences. The present objectives were to investigate 1) possible associations between the severity of the cleft lip deficiency in patients with UCLP and variations in dento-facial growth and development, and 2) whether variation in stability following orthognathic surgery to permit adequate functional jaw relations and harmonious facial esthetics could be explained by the magnitude or segmentation of maxillary advancement. The results suggest that children with a more severe form of UCLP at infancy are susceptible to tooth agenesis in the cleft area, poorer dental arch relationships, and more deficient maxillary growth. The stability of maxillary advancement appears to be independent of magnitude or segmentation.
Panoramic radiography for routine dental implant planning in the posterior mandible
Creators: name: Vazquez, Lydia
Publisher: name: Université de Genève
Year: 2015
Subjects: info:eu-repo/classification/ddc/617.6
Dental implant
Inferior alveolar nerve injury
Mandibular canal
Lingual undercut
Panoramic radiography
Computed tomography
Cone beam computed tomography

description: Dental implants are a widely used treatment option to replace missing teeth. Along with the growing popularity of dental implants, 2 and 3-dimensional imaging modalities have become commonplace. In the posterior mandible, visualization of the mandibular canal is essential to select the correct implant length, thereby limiting the risk of inferior alveolar nerve injury that can lead to irreversible sensory disturbance of the lower lip and chin. Unfortunately, no preoperative imaging modality gives a “perfect” visualization of the mandibular canal. Non-essential radiation exposure should be avoided and unconsidered systematic preimplant 3-dimensional imaging is to be discouraged. For routine posterior mandibular implant planning, a thorough clinical examination of the mandibular morphology and a panoramic radiograph are recommended. When a safety margin of at least 2 mm is respected, panoramic radiography is sufficiently accurate to evaluate the available bone height above the mandibular canal.
High throughput sequencing for the diagnosis of inherited hypertrophic cardiomyopathy and other mendelian cardiac disorders
Creators: name: Fokstuen, Siv
Publisher: name: Université de Genève
Year: 2015
Subjects: info:eu-repo/classification/ddc/576.5
High throughput sequencing
Hypertrophic cardiomyopathy
Mendelian cardiac disorders

description: During the last decade, molecular genetics has provided important new insights into the pathogenesis of inherited cardiomyopathies and arrhythmias. However, their extensive genetic heterogeneity means that mutation detection by classical serial molecular techniques is time-consuming, expensive, and difficult to perform in a routine clinical screening. The situation has improved dramatically with the introduction of high throughput sequencing (HTS) platforms, which allow simultaneous screening of a large number of genes. We have developed different custom high throughput sequencing approaches for mendelian cardiac disorders. We started with a 12 gene DNA resequencing array for HCM, continued with a multiplex capture array harbouring 130 genes causative of all subtypes of inherited cardiomyopathies, their phenocopies, some arrhythmias and connective tissue disorders and ended up with a custom targeted gene panel for inherited cardiomyopathies. All these approaches showed to be reliable mutation detection tools but also highlighted the complexity of variant interpretation as the most demanding challenge of HTS methods.