cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Long-term alpine summit vegetation cover change: Divergent trajectories driven by climate warming and fire
Creators: name: Hickman, Iris T.
name: Camac, James S.
name: Venn, Susanna E.
name: Morgan, John W.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Alpine summit vegetation, the highest point of species geographical distributions, is vulnerable to climate change (thermal niche contraction), and there is evidence of change in Northern Hemisphere summits. However, summits are experiencing multifaceted change due to warming and increasing fire frequency. Little is known about how these factors are affecting alpine summit vegetation. We used a revisitation approach to capture the long-term (eighteen years) dynamic changes in Australian alpine plant summit community patterns and to understand the mechanisms of change. We found that vegetation change was influenced by climate and moderated by site-specific factors. There was increased shrub cover over time; however, summit vegetation was largely stable unless disturbed. Fire-disturbed summits experienced higher instability in their vegetation cover over time. Linear mixed-effect models indicated that as time since fire increased and the growing degrees accumulated, there was a strong positive effect on forb and graminoid cover and a negative effect on shrub cover. Forb cover was higher at cooler, wetter, higher-elevation summits. These findings indicate the multifaceted nature of change that must be accounted for in alpine vegetation studies. We show that alpine summit vegetation will respond multidirectionally to a warming climate and changing fire regimes, with outcomes likely contingent on life history characteristics.
Partizipation In Der Projektorientierten Jugendarbeit: Ein Vergleich Von Theorie Und Praxis
Creators: name: Kuhn, Lucia
name: Wenk, Christian
Publisher: name: Zenodo
Year: 2008
Subjects: subject: gnd:4028863-8
subject: gnd:4115646-8
subject: gnd:4044789-3

description: Die vorliegende Bachelorarbeit beschäftigt sich mit der Frage, ob Diskrepanzen zwischen Theorie und Praxis betreffend Partizipation in der projektorientierten Jugendarbeit bestehen. Partizipation ist wichtiger Bestandteil der direkten Demokratie und somit auch der Soziokulturellen Animation. Im Rahmen ihrer beruflichen Tätigkeit sehen sich die Autorin und der Autor in der Umsetzung immer wieder mit Hindernissen konfrontiert. Um die Frage beantworten zu können, wurde eine Literaturrecherche vorgenommen und die Praxis mittels Experten/Expertinneninterviews untersucht. Der Vergleich von Theorie und empirischer Forschung zeigt auf, dass Unterschiede bestehen. Wie gross die Differenzen sind, variiert zwischen den drei untersuchten Themenbereichen, der Ausrichtung projektorientierter Jugendarbeit, dem Stellenwert von Partizipation in Projekten und der Analyse von Partizipation in der Arbeit. Diskrepanzen bestehen insbesondere aufgrund der gegebenen Strukturen der Arbeitsstellen und deren Einbindung ins politische System, dem Einsatz von Partizipation als Mittel oder als Ziel sowie in der Auslegung der Rolle der Professionellen. Verschiedene Handlungsansätze zeigen auf, welche Möglichkeiten bestehen, diese Diskrepanzen seitens der Praxis abzubauen. Dabei werden Empfehlungen im Umgang mit der Politik und der Öffentlichkeit, der eigenen Rolle sowie dem Einsatz von Partizipation als Ziel gemacht. Des Weiteren werden die Professionellen aufgerufen, einen pragmatischen aber reflektierten Umgang mit der Theorie zu pflegen und sich der Kernaufgabe Partizipation in der Soziokulturellen Animation bewusst zu sein.
description: + Code Diss LU: hslusa bask 2008
+ Fussnote: Bachelor-Arbeit, Hochschule Luzern - Soziale Arbeit, Ausbildungsgang Sozialarbeit, 2008
sj-pdf-2-wso-10.1177_17474930211052816 - Supplemental material for Posterior circulation stroke due to vertebral artery disease in the Chinese population
Creators: name: Zhang, Changqing
name: Li, Zixiao
name: Liu, Liping
name: Pu, Yuehua
name: Zou, Xinying
name: Yan, Hongyi
name: Pan, Yuesong
name: Zhao, Xingquan
name: Wang, Yilong
name: Wang, Yongjun
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Cardiology
subject: Medicine
subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-2-wso-10.1177_17474930211052816 for Posterior circulation stroke due to vertebral artery disease in the Chinese population by Changqing Zhang, Zixiao Li, Liping Liu, Yuehua Pu, Xinying Zou, Hongyi Yan, Yuesong Pan, Xingquan Zhao, Yilong Wang and Yongjun Wang in International Journal of Stroke
Modelo de Negocios para Campamentos Infanto Juveniles cubanos orientado al mercado internacional.
Creators: name: Ariadna García Quintana
name: Gerson Herrera Pupo
name: Fidel García González
Publisher: name: Zenodo
Year: 2025

description: El turismo en Cuba enfrenta grandes desafíos tras la pandemia, lo que exige modelos de negocio innovadores y sostenibles. El trabajo propone un modelo de negocio para campamentos infanto-juveniles dirigidos al mercado internacional, utilizando el Modelo Canvas como herramienta estratégica. Este enfoque permite identificar segmentos de clientes, diseñar propuestas de valor únicas y optimizar recursos para maximizar la rentabilidad.

Con la aplicación del mismo se logrará diseñar una propuesta de valor única y diferenciadora para estos campamentos, enfocada en la combinación de actividades educativas, recreativas y culturales en un entorno seguro y enriquecedor. Esta innovación es clave para destacarse en un mercado turístico cada vez más competitivo.  Gracias al análisis detallado de los bloques del modelo Canvas, se podrá identificar y optimizar los recursos necesarios para la operación de los campamentos infantojuveniles, desde el personal especializado hasta las instalaciones y servicios adicionales, lo que contribuye a una gestión eficiente de costos y una mayor rentabilidad del negocio a largo plazo. También se identificarán posibles alianzas estratégicas con otros actores del sector turístico internacional, como agencias de viajes, operadores o instituciones educativas, que pueden potenciar la comercialización y promoción de los campamentos, ampliando su alcance y llegando a nuevos segmentos de clientes.

La aplicación del Modelo Canvas a este producto sienta las bases para su sostenibilidad y éxito. Al tener una visión integral y estratégica del negocio, se pueden tomar decisiones informadas, identificar oportunidades de mejora y garantizar la viabilidad y rentabilidad del proyecto en un entorno turístico dinámico y cambiante.

 

Palabras claves: Turismo Educativo, Modelo de Negocios para productos turísticos, Modelo Canvas, Campamentos Infanto Juveniles.
Additional file 1 of Attenuating mitochondrial dysfunction and morphological disruption with PT320 delays dopamine degeneration in MitoPark mice
Creators: name: Wang, Vicki
name: Tseng, Kuan-Yin
name: Kuo, Tung-Tai
name: Huang, Eagle Yi-Kung
name: Lan, Kuo-Lun
name: Chen, Zi-Rong
name: Ma, Kuo-Hsing
name: Greig, Nigel H.
name: Jung, Jin
name: Choi, Ho-II
name: Olson, Lars
name: Hoffer, Barry J.
name: Chen, Yuan-Hao
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Cancer

description: Supplementary Material 1.
Structural insights into non-hotspot KRAS mutations and their potential as targets for effective cancer therapies
Creators: name: Ding, Cong
name: Wang, Gaoyuan
name: Zou, Wenqing
name: Mao, Yanping
name: Ma, Jun
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Kirsten rat sarcoma virus protein (KRAS) is a protein that plays a central role in signal transduction using extracellular signal regulated kinase (ERK) and mitogen activated protein kinase (MAPK) cellular signaling pathway. KRAS is a frequently mutated oncogene and plays a pivotal role in tumor initiation and progression. Hotspot mutations on codon 12, 13 and 61 in KRAS are well-known for their role in drug resistance and non-hotspot mutations also play a significant part in contributing to resistance mechanisms. The understanding of how these non-hotspot mutations might affect the signal transduction of KRAS and their contribution towards drug resistance is understudied. Here we provide structural insights into the interaction of non-hotspot KRAS mutants with GTP (the native ligand) using a molecular docking and molecular dynamics simulation approach. Extensive molecular docking and simulation studies suggest that non-hotspot mutations (E31D and E63K) show stable interaction with native ligand using all five trajectories, as evidenced by root mean square of distance (RMSD), root mean square of fluctuation (RMSF), radius of gyration (RoG), coulomb short-range energy and MMGBSA analysis. These results suggest that non-hotspot mutations do not undermine the oncogenic nature of KRAS. This observation is consistent with previous findings where overexpressing E31D and E63K mutations share phenotypic features with G12D and G13D transfected cells, including increased proliferative capacity, actin cytoskeleton organization, and migration rates. We further test whether FDA-approved KRAS inhibitors sotorasib and adagrasib successfully inhibit the E31D and E63K mutants. Results suggest that these two non-hotspot mutants can be inhibited by both drugs with following trend of structural stability (E31D > E63K > wild-KRAS > Q61H > G12C). Based on sharp coherence in trajectories between wild KRAS and non-hotspot mutants, it is suggested that these novel mutants do not contribute to drug resistance mechanism. Overall, we provide a comprehensive understanding of the impact of non-hotspot mutations on KRAS and their potential as targets for effective cancer therapies.
Report On The Open Access Database
Creators: name: Trumpy, Eugenio
name: Manzella, Adele
name: Botteghi, Serena
Publisher: name: Zenodo
Year: 2016
Subjects: geothermal energy
exploration
europe
mexico
los humeros
acoculco
database
dataset
geophysics
geology
geochemistry

description: This report includes the description of the GEMex Open Access Database implementation and the collection of data. Geothermal data, in the form of maps, datasets and models will be organized and stored in an Open Access Database and will be made available in a Spatial Data Infrastructure according to international standards and protocols.

Part of this report is in the form of a handbook to help user to access the available information. The database is available by a dedicated link in the project website and will be updated by the end of the project.
description: H2020
description: {"references": ["GeoNode web site \u2013 http://geonode.org", "GeoNode documentation: http://docs.geonode.org", "GeoNode Development Team \u2013 GeoNode Documentation, Release 2.4. \u2013 2015. Available on line at the URL: https://media.readthedocs.org/pdf/GeoNode/latest/GeoNode.pdf", "OGC Services - OGC Services \u2013 http://www.opengeospatial.org/", "Open Geospatial Consortium \u2013 http://en.wikipedia.org/wiki/Open_Geospatial_Consortium"]}
sj-pdf-1-prs-10.1177_20414196211052062 – Supplemental material for Blast mitigation using polymeric 3D printed auxetic re-entrant honeycomb structures: A preliminary study
Creators: name: Critchley, Richard
name: Hazael, Rachael
name: Bhatti, Kamran
name: Wood, David
name: Peare, Alan
name: Johnson, Stephen
name: Temple, Tracey
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, sj-pdf-1-prs-10.1177_20414196211052062 for Blast mitigation using polymeric 3D printed auxetic re-entrant honeycomb structures: A preliminary study by Richard Critchley, Rachael Hazael, Kamran Bhatti, David Wood, Alan Peare, Stephen Johnson and Tracey Temple in International Journal of Protective Structures
Optimización del sistema de control de gestión del Hotel Brisas Santa Lucía
Creators: name: Manuel Ignacio Menéndez Sánchez
name: Elena Lorenzo Kómova
Publisher: name: Zenodo
Year: 2025

description: El sector hotelero enfrenta constantes desafíos en la gestión eficiente de sus operaciones. Este estudio optimiza el sistema de control de gestión del Hotel Brisas Santa Lucía, donde se identificaron problemas como análisis operativos fragmentados, detección tardía de desviaciones y falta de integración entre áreas. Estas limitaciones afectaban la eficiencia organizacional y la capacidad de respuesta ante cambios del mercado. Materiales y métodos: Se desarrolló una metodología estructurada en seis fases: diagnóstico inicial, formulación estratégica, diseño de indicadores clave, implementación gradual, evaluación sistemática y retroalimentación continua. El enfoque combinó técnicas cuantitativas y cualitativas, integrando perspectivas financieras, operativas y de desarrollo organizacional. Se establecieron mecanismos para monitorear resultados y factores impulsores del desempeño. Resultados: La implementación demuestra mejoras significativas en gestión de recursos y coordinación interdepartamental. El sistema proporciona información actualizada para seguimiento de objetivos, fomenta una actitud proactiva ante desafíos y evalúa la efectividad de las acciones ejecutadas. Los datos muestran incrementos en eficiencia operativa y calidad de servicio. Discusión: Los resultados validan la efectividad de sistemas de control multidimensionales en hotelería. La integración de perspectivas financieras y operativas resulta crucial para la toma de decisiones estratégicas. La investigación destaca la importancia de procesos continuos de evaluación y ajuste, proponiendo este modelo como referencia para organizaciones turísticas que busquen mejorar su competitividad mediante gestión basada en datos.

Palabras clave: competitividad turística, control de gestión hotelera, eficiencia operativa, modelo integral, toma de decisiones.
sj-pdf-1-epx-10.1177_08959048211049429 – Supplemental material for Teacher Quality and Students’ Post-Secondary Outcomes
Creators: name: Graham, Jerome
name: Flamini, Monica
Publisher: name: SAGE Journals
Year: 2021
Subjects: Education

description: Supplemental material, sj-pdf-1-epx-10.1177_08959048211049429 for Teacher Quality and Students’ Post-Secondary Outcomes by Jerome Graham and Monica Flamini in Educational Policy
Antiviral actions of natural compounds against dengue virus RNA dependent RNA polymerase: insights from molecular dynamics and Gibbs free energy landscape
Creators: name: Rabaan, Ali A.
name: Al Kaabi, Nawal A.
name: Muzaheed
name: Alfaresi, Mubarak
name: Garout, Mohammed
name: Alotaibi, Nouf
name: Alwashmi, Ameen S. S.
name: Alsayyah, Ahmed
name: Alali, Neda A.
name: Sulaiman, Tarek
name: Alotaibi, Jawaher
name: Alissa, Mohammed
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Information Systems not elsewhere classified
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Dengue fever, a major global health challenge, affects nearly half the world’s population and lacks effective treatments or vaccines. Addressing this, our study focused on natural compounds that potentially inhibit the dengue virus’s RNA-dependent RNA polymerase (RdRp), a crucial target in the viral replication cycle. Utilizing the MTiOpenScreen webserver, we screened 1226 natural compounds from the NP-lib database. This screening identified four promising compounds ZINC000059779788, ZINC0000044404209, ZINC0000253504517 and ZINC0000253499146), each demonstrating high negative binding energies between −10.4 and −9.9 kcal/mol, indicative of strong potential as RdRp inhibitors. These compounds underwent rigorous validation through re-docking and a detailed 100 ns molecular dynamics (MD) simulation. This analysis affirmed the dynamic stability of the protein-ligand complexes, a critical factor in the effectiveness of potential drug candidates. Additionally, we conducted essential dynamics and free energy landscape calculations to understand the structural transitions in the RdRp protein upon ligand binding, providing valuable insights into the mechanism of inhibition. Our findings present these natural molecules as promising therapeutic agents against the dengue virus. By targeting the allosteric site of RdRp, these compounds offer a novel approach to hinder the viral replication process. This research significantly contributes to the search for effective anti-dengue treatments, positioning natural compounds as potential key players in dengue virus control strategies.
1,2,3, many: perceptual order is computed by patches containing 3x3 "repetitions" of Motifs
Creators: name: Katkov, Mikhail
name: Harris, Hila
name: Sagi, Dov
Publisher: name: F1000Research
Year: 2017

description: Using methods of statistical physics we have created stimuli that vary in the amount of order. Next, created stimuli were trimmed to have different number of repeating cells (the basic unit used to tile 2D space) and different scales. We have measured the performance of human observers in discriminating patches with different amount of order and random patches. We have obtained that the human observers have the same psychometric curves for patches of 3x3 repetitions and larger, whereas 2x2 repetitions were different from chance performance only when cells had an internal structure. Scaling patches had no effect on performance, pointing to the importance of the content, and not the physical size of the patches.
sj-docx-1-cse-10.1177_20471734211050290 - Supplemental material for All things considered: The views of adolescents in vocational education on competing democratic values
Creators: name: Vaessen, Annabel
name: Daas, Remmert
name: Nieuwelink, Hessel
Publisher: name: SAGE Journals
Year: 2021
Subjects: Education

description: Supplemental material, sj-docx-1-cse-10.1177_20471734211050290 for All things considered: The views of adolescents in vocational education on competing democratic values by Annabel Vaessen, Remmert Daas and Hessel Nieuwelink in Citizenship, Social and Economics Education
Computational insights into dynamics and conformational stability of N-acetylmannosamine kinase mutations
Creators: name: Abdel-Naim, Ashraf B.
name: Kumar, Pawan
name: Bazuhair, Mohammed A.
name: Rizg, Waleed Y.
name: Niyazi, Hatoon A.
name: Alkuwaity, Khalil
name: Niyazi, Hanouf A.
name: Alharthy, Saif A.
name: Harakeh, Steve
name: Haque, Shafiul
name: Prakash, Amresh
name: Kumar, Vijay
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Virology
subject: Computational Biology

description: The activity of UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE) is essential for the biosynthesis of sialic acid, which is involved in cellular processes in health and diseases. GNE contains an N-terminal epimerase domain and a C-terminal kinase domain (N-acetylmannosamine kinase, MNK). Mutations of the GNE protein led to hypoactivity of the enzyme and cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy. Here, we used all-atom molecular dynamics (MD) simulations to comprehend the folding, dynamics and conformational stability of MNK variants, including the wild type (WT) and three mutants (H677R, V696M and H677R/V696M). The deleterious and destabilizing nature of MNK mutants were predicted using different prediction tools. Results predicted that mutations modulate the stability, flexibility and function of MNK. The effect of mutations on the conformational stability and dynamics of MNK was next studied through the free-energy landscape (FEL), hydrogen-bonds and secondary structure changes. The FEL results show that the mutations interfere with various conformational transitions in both WT and mutants, exposing the structural underpinnings of protein destabilization and unfolding brought on by mutation. We discover that, when compared to the other two mutations, V696M and H677R/V696M, H677R has the most harmful effects. These findings have a strong correlation with published experimental studies that demonstrate how these mutations disrupt MNK activity. Hence, this computational study describes the structural details to unravel the mutant effects at the atomistic resolution and has implications for understanding the GNE's physiological and pathological role.
sj-pdf-1-cpx-10.1177_21677026211049366 – Supplemental material for Effect Sizes Reported in Highly Cited Emotion Research Compared With Larger Studies and Meta-Analyses Addressing the Same Questions
Creators: name: Cristea, Ioana A.
name: Georgescu, Raluca
name: Ioannidis, John P. A.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, sj-pdf-1-cpx-10.1177_21677026211049366 for Effect Sizes Reported in Highly Cited Emotion Research Compared With Larger Studies and Meta-Analyses Addressing the Same Questions by Ioana A. Cristea, Raluca Georgescu and John P. A. Ioannidis in Clinical Psychological Science
sj-docx-1-car-10.1177_19476035211053824 – Supplemental material for Apolipoprotein D as a Potential Biomarker and Construction of a Transcriptional Regulatory-Immune Network Associated with Osteoarthritis by Weighted Gene Coexpression Network Analysis
Creators: name: Qin, Yong
name: Li, Jia
name: Zhou, Yonggang
name: Yin, Chengliang
name: Li, Yi
name: Chen, Ming
name: Du, Yinqiao
name: Li, Tiejian
name: Yan, Jinglong
Publisher: name: SAGE Journals
Year: 2021
Subjects: Orthopaedics
Sports Medicine
Surgery
Biological Sciences not elsewhere classified

description: Supplemental material, sj-docx-1-car-10.1177_19476035211053824 for Apolipoprotein D as a Potential Biomarker and Construction of a Transcriptional Regulatory-Immune Network Associated with Osteoarthritis by Weighted Gene Coexpression Network Analysis by Yong Qin, Jia Li, Yonggang Zhou, Chengliang Yin, Yi Li, Ming Chen, Yinqiao Du, Tiejian Li and Jinglong Yan in CARTILAGE
sj-pdf-1-teu-10.1177_13548166211052139 – Supplemental Material for Deep habits and travel resilience after COVID-19
Creators: name: Boto-García, David
name: Baños-Pino, José F
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Economics
subject: 150402 Hospitality Management
subject: FOS: Economics and business

description: Supplemental Material, sj-pdf-1-teu-10.1177_13548166211052139 for Deep habits and travel resilience after COVID-19 by David Boto-García and José F Baños-Pino in Tourism Economics
Additional file 2 of The phenotypic spectrum of terminal 6q deletions based on a large cohort derived from social media and literature: a prominent role for DLL1
Creators: name: Engwerda, Aafke
name: Kerstjens-Frederikse, Wilhelmina S.
name: Corsten-Janssen, Nicole
name: Dijkhuizen, Trijnie
name: van Ravenswaaij-Arts, Conny M. A.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Additional file2. Figure S1: Case collection from the Chromosome 6 Project and literature. Figure S2: Developmental delay in children older than 2 years of age. Figure S3: Delayed Myelination. Figure S4: Dental problems. Table S2: HI and pLI scores. Table S4: Genes mentioned in the Discussion and the clinical characteristics to which they may contribute.
sj-pdf-1-jag-10.1177_07334648211053000 – Supplemental Material for Mind–Body Interventions in Patients With Heart Failure: State of the Science
Creators: name: Suksatan, Wanich
name: Tankumpuan, Thitipong
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: 110308 Geriatrics and Gerontology
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental Material, sj-pdf-1-jag-10.1177_07334648211053000 for Mind–Body Interventions in Patients With Heart Failure: State of the Science by Wanich Suksatan and Thitipong Tankumpuan in Journal of Applied Gerontology
Potential bioactive compound and hub gene identification of endometrial carcinoma using systems biology
Creators: name: Rishikesan, Shanmugapriya
name: Brindhadevi, Parthiban
name: K., Rajakumari
name: Srinath, N.
name: Balamugundhan, M.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Endometrial carcinoma is a frequent cancer of the female genital tract. Endometrial carcinoma accounts for 97% of all uterine malignancies and 3 % of sarcomas that develop from the endometrium’s glands. Endometrial cancer is frequently found in its early stages since most women quickly report postmenopausal vaginal hemorrhage. The need for more advanced medications to improve survival in such situations is still unfulfilled. As a result, there is growing interest in employing an herbal treatment to treat endometriosis, which seems to be an effective strategy. We have discovered a few unintended targets (ligands) in our investigation that are active components of common therapeutic herbs. The differentially expressed genes (DEG - target protein) for endometrial cancer were found using the NCBI and CIViC databases. In our investigation, the protein used for docking and simulation was PDB ID: 3THW. Using the Cytoscape server, the gene-encoding protein network has been identified. It was discovered that the Protein 3THW's binding energy to the bioactive substance (Asarone) was −7.15 Kcal/mol. It was discovered that the crucial interacting amino acid residues were ILE648, PHE650, ILE651, VAL802, TYR815, VAL817. The properties of the pharmaceutical target are further investigated by employing a molecular simulation study for 100 ns with NAMD software. Low RMSD and SASA (Solvent accessible surface area), high RMSF, High hydrogen bonds, between Asarone and MSH2 demonstrated their potency as endometrial cancer inhibitor compounds. Based on these analyses we infer that the bioactive substances originating from medicinal plants may be an effective treatment for endometrial cancer.
sj-docx-4-tct-10.1177_15330338211052150 - Supplemental material for LncRNA OIP5-AS1 Promotes the Autophagy-Related Imatinib Resistance in Chronic Myeloid Leukemia Cells by Regulating miR-30e-5p/ATG12 Axis
Creators: name: Dai, Hongdan
name: Wang, Jianming
name: Huang, Zhenglan
name: Zhang, Hui
name: Wang, Xin
name: Li, Qian
name: Feng, Wenli
Publisher: name: SAGE Journals
Year: 2021
Subjects: Oncology and Carcinogenesis not elsewhere classified
Radiology and Organ Imaging
Biochemistry

description: Supplemental material, sj-docx-4-tct-10.1177_15330338211052150 for LncRNA OIP5-AS1 Promotes the Autophagy-Related Imatinib Resistance in Chronic Myeloid Leukemia Cells by Regulating miR-30e-5p/ATG12 Axis by Hongdan Dai, Jianming Wang, Zhenglan Huang, Hui Zhang, Xin Wang, Qian Li and Wenli Feng in Technology in Cancer Research & Treatment
Network-base approaches to identify therapeutic biomarkers in hepatocellular carcinoma and search for drug hunting utilizing molecular dynamics simulations
Creators: name: Ayaz, Hassan
name: Ahmad, Faisal
name: Ahmad, Sajjad
name: Arfan, Qaiser
name: Alasmari, Abdullah F.
name: Siddique, Farhan
name: Rehman, Bushra
name: Zeb, Adnan
name: Crovella, Sergio
name: Ali, Syed Shujait
name: Waheed, Yasir
name: Suleman, Muhammad
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biophysics
Biochemistry
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Cancer
Virology
Computational Biology

description: The presence of conditions like Alpha-1 antitrypsin deficiency, hemochromatosis, non-alcoholic fatty liver diseases and metabolic syndrome can elevate the susceptibility to hepatic cellular carcinoma (HCC). Utilizing network-based gene expression profiling via network analyst tools, presents a novel approach for drug target discovery. The significance level (p-score) obtained through Cytoscape in the intended center gene survival assessment confirms the identification of all target center genes, which play a fundamental role in disease formation and progression in HCC. A total of 1064 deferential expression genes were found. These include MCM2 with the highest degree, followed by 4917 MCM6 and MCM4 with a 3944-degree score. We investigated the regulatory kinases involved in establishing the protein-protein interactions network using X2K web tool. The docking approach yields a favorable binding affinity of −8.7 kcal/mol against the target MCM2 using Auto-Dock Vina. Interestingly after simulating the complex system via AMBER16 package, results showed that the root mean square deviation values remained within 4.74 Å for a protein and remains stable throughout the time intervals. Additionally, the ligand’s fit to the protein exhibited fluctuations at some intervals but remains stable. Finally, Gibbs free energy was found to be at its lowest at 1 kcal/mol which presents the real time interactive binding of the atomic residues among inhibitor and protein. The displacement of the ligand was measured showing stable movement and displacement along the active site. These findings increased our understanding for potential biomarkers in hepatocellular carcinoma and an experimental approach will further enhance our outcomes in future.
Molecular interaction of quercetin and its derivatives against nucleolin in breast cancer: in-silico and in-vitro study
Creators: name: Shaw, Siuli
name: Chourasia, Mukesh
name: Nayak, Ranu
name: Kumeria, Tushar
name: Ghosh, Madhumita P.
name: Santoshi, Seneha
name: Bose, Sudeep
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Nucleolin, a multifaceted RNA binding domain protein is overexpressed in various cancers leading to dysfunction of several cellular signaling pathways. Quercetin, a distinctive bioactive molecule, along with its derivatives have shown exclusive physio-chemical properties which makes them appealing choices for drug development, yet their role in targeted cancer therapy is limited. Here, the RBD domain structure of Nucleolin was modeled and stabilized by MD simulations for a period of 1000 ns. Molecular docking was performed to determine the binding capability of ligands with the target. To determine the stability of the ligand inside the binding pocket of the protein, MD simulation was performed for a period of 250 ns each for Quercetin-4'-o'-Glucoside, Quercetin_9 and Quercetin complexes. Further, in-vitro studies including cytotoxicity and RT-PCR assays were performed to validate quercetin against Nucleolin. Molecular docking and MD Simulation studies suggested a potential mechanism of interaction of Quercetin-4'-o'-Glucoside, Querectin_9 and Quercetin with Nucleolin with the binding free energy of −63.653, −58.86 and −46.9 kcal/mol, respectively. Moreover, Lys 348 and Glu379 were identified as important amino acids in ligand interaction located at the RRM2 motif of Nucleolin. In-vitro studies showed significant downregulation in Nucleolin expression by 15.18 and 2.51-fold at 48h and 72h respectively in MCF-7 cells with Quercetin (IC50 = 160 µM). Our findings suggested the potential role of specific RRM motifs in interaction with natural compounds targeting Nucleolin. This could be an effective strategy in the identification of potential molecules in targeting Nucleolin which can be further explored for developing targeted therapies for breast cancer.
sj-pdf-2-imr-10.1177_03000605211049960 - Supplemental material for Associations between traditional and non-traditional anthropometric indices and cardiometabolic risk factors among inpatients with type 2 diabetes mellitus: a cross-sectional study
Creators: name: Golabi, Sahar
name: Ajloo, Sajad
name: Maghsoudi, Fatemeh
name: Adelipour, Maryam
name: Naghashpour, Mahshid
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: Cardiology
subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine
subject: 110305 Emergency Medicine
subject: 110306 Endocrinology
subject: 110308 Geriatrics and Gerontology
subject: 110904 Neurology and Neuromuscular Diseases
subject: 111099 Nursing not elsewhere classified
subject: 111199 Nutrition and Dietetics not elsewhere classified
subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: 110314 Orthopaedics
subject: 110604 Sports Medicine
subject: 110315 Otorhinolaryngology
subject: 111702 Aged Health Care
subject: 111403 Paediatrics
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 110203 Respiratory Diseases
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology
subject: 110323 Surgery

description: Supplemental material, sj-pdf-2-imr-10.1177_03000605211049960 for Associations between traditional and non-traditional anthropometric indices and cardiometabolic risk factors among inpatients with type 2 diabetes mellitus: a cross-sectional study by Sahar Golabi, Sajad Ajloo, Fatemeh Maghsoudi, Maryam Adelipour and Mahshid Naghashpour in Journal of International Medical Research
Land Use and Its Impact on Phosphorus Adsorption Capacity in a Tropical Dryland Agricultural Frontier: Insights and Predictive Modeling
Creators: name: de Souza, José Wilker G.
name: da Luz, João H. S.
name: Silva, Dayane M. R.
name: Silva, Ricardo B.
name: Paulino, Sivaldo S.
name: da S. Marques, Isabelly C.
name: de O. Galdino, Wesley
name: de Sousa, Jadielson I.
name: Do N. S. Barbosa, Luana
name: Melo, Alan F.
name: de Souza, Weslly G.
name: da S. Lira, Viviane
name: dos Santos, Valdevan R.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Cancer
subject: Plant Biology

description: Land use significantly impacts the physical-chemical properties of soil, particularly in tropical regions where the maximum phosphorus adsorption capacity (MPAC) plays a crucial role in agricultural sustainability. This study evaluates the influence of land uses (cropland, grassland, and forest) on MPAC in dryland soils of Sergipe, Alagoas, and Bahia (SEALBA) agricultural frontier in Northeast Brazil. Soil samples from nine sites were analyzed for their physical-chemical characteristics (potential of hydrogen (pH), available phosphorus (P), remaining P, soil organic matter (SOM), calcium and magnesium content, exchangeable aluminum, potential acidity and texture) in the 0–20 cm soil depth. MPAC was determined using two isotherm models, and three predictive models were applied. The results revealed that cropland soils exhibit the highest MPAC, contrary to expectations of lower values due to legacy P from P inputs. However, MPAC varied slightly across sites, indicating specific dependencies on soil physical-chemical properties and suggesting that land use may have a more significant influence over the long term. Random forest and decision tree models identified SOM and available P as the most significant predictors of MPAC, yet with these routine soil fertility indicators alone, the maximum explanatory power (R2) was 75% with a precision (RMSE) of 77 mg kg−1 using the random forest model. Consequently, the conversion of forest to cropland can increase MPAC, and predicting MPAC can be a valuable tool for guiding land use and assisting in the formulation of more sustainable agricultural and environmental policies, particularly in dryland agricultural frontiers.
sj-docx-1-prs-10.1177_20414196211052062 – Supplemental material for Blast mitigation using polymeric 3D printed auxetic re-entrant honeycomb structures: A preliminary study
Creators: name: Critchley, Richard
name: Hazael, Rachael
name: Bhatti, Kamran
name: Wood, David
name: Peare, Alan
name: Johnson, Stephen
name: Temple, Tracey
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, sj-docx-1-prs-10.1177_20414196211052062 for Blast mitigation using polymeric 3D printed auxetic re-entrant honeycomb structures: A preliminary study by Richard Critchley, Rachael Hazael, Kamran Bhatti, David Wood, Alan Peare, Stephen Johnson and Tracey Temple in International Journal of Protective Structures
sj-docx-2-car-10.1177_19476035211053824 – Supplemental material for Apolipoprotein D as a Potential Biomarker and Construction of a Transcriptional Regulatory-Immune Network Associated with Osteoarthritis by Weighted Gene Coexpression Network Analysis
Creators: name: Qin, Yong
name: Li, Jia
name: Zhou, Yonggang
name: Yin, Chengliang
name: Li, Yi
name: Chen, Ming
name: Du, Yinqiao
name: Li, Tiejian
name: Yan, Jinglong
Publisher: name: SAGE Journals
Year: 2021
Subjects: Orthopaedics
Sports Medicine
Surgery
Biological Sciences not elsewhere classified

description: Supplemental material, sj-docx-2-car-10.1177_19476035211053824 for Apolipoprotein D as a Potential Biomarker and Construction of a Transcriptional Regulatory-Immune Network Associated with Osteoarthritis by Weighted Gene Coexpression Network Analysis by Yong Qin, Jia Li, Yonggang Zhou, Chengliang Yin, Yi Li, Ming Chen, Yinqiao Du, Tiejian Li and Jinglong Yan in CARTILAGE
sj-docx-3-car-10.1177_19476035211053824 – Supplemental material for Apolipoprotein D as a Potential Biomarker and Construction of a Transcriptional Regulatory-Immune Network Associated with Osteoarthritis by Weighted Gene Coexpression Network Analysis
Creators: name: Qin, Yong
name: Li, Jia
name: Zhou, Yonggang
name: Yin, Chengliang
name: Li, Yi
name: Chen, Ming
name: Du, Yinqiao
name: Li, Tiejian
name: Yan, Jinglong
Publisher: name: SAGE Journals
Year: 2021
Subjects: Orthopaedics
Sports Medicine
Surgery
Biological Sciences not elsewhere classified

description: Supplemental material, sj-docx-3-car-10.1177_19476035211053824 for Apolipoprotein D as a Potential Biomarker and Construction of a Transcriptional Regulatory-Immune Network Associated with Osteoarthritis by Weighted Gene Coexpression Network Analysis by Yong Qin, Jia Li, Yonggang Zhou, Chengliang Yin, Yi Li, Ming Chen, Yinqiao Du, Tiejian Li and Jinglong Yan in CARTILAGE
sj-pdf-1-asr-10.1177_00031224211049188 – Supplemental material for Does Schooling Decrease Socioeconomic Inequality in Early Achievement? A Differential Exposure Approach
Creators: name: Passaretta, Giampiero
name: Skopek, Jan
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Sociology
subject: FOS: Sociology

description: Supplemental material, sj-pdf-1-asr-10.1177_00031224211049188 for Does Schooling Decrease Socioeconomic Inequality in Early Achievement? A Differential Exposure Approach by Giampiero Passaretta and Jan Skopek in American Sociological Review
sj-docx-1-jfm-10.1177_1098612X211053484 – Supplemental material for Evaluation of a nutritional supplement for the alleviation of pain associated with feline degenerative joint disease: a prospective, randomized, stratified, double-blind, placebo-controlled clinical trial
Creators: name: Cunningham, Rachael
name: Gruen, Margaret E
name: Thomson, Andrea
name: Lascelles, B Duncan X
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 70706 Veterinary Medicine
subject: FOS: Veterinary sciences

description: Supplemental material, sj-docx-1-jfm-10.1177_1098612X211053484 for Evaluation of a nutritional supplement for the alleviation of pain associated with feline degenerative joint disease: a prospective, randomized, stratified, double-blind, placebo-controlled clinical trial by Rachael Cunningham, Margaret E Gruen, Andrea Thomson and B Duncan X Lascelles in Journal of Feline Medicine and Surgery
Supplemental Material, sj-docx-1-wcc-10.1177_2631309X211050013 - What Are the Merits of Taking a Hybrid Regulatory Approach Toward the Enforcement of Corporate Financial Crime in the United Kingdom and United States of America?
Creators: name: Johnson, Diana
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law

description: Supplemental Material, sj-docx-1-wcc-10.1177_2631309X211050013 for What Are the Merits of Taking a Hybrid Regulatory Approach Toward the Enforcement of Corporate Financial Crime in the United Kingdom and United States of America? by Diana Johnson in Journal of White Collar and Corporate Crime
sj-docx-2-arpa-10.1177_02750740211050577 - Supplemental material for Walking the Talk of Social Equity? Street-Level Bureaucrats’ Decisionmaking About the Provision of Personal Resources
Creators: name: Lavee, Einat
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160607 International Relations
subject: FOS: Political science
subject: 160509 Public Administration

description: Supplemental material, sj-docx-2-arpa-10.1177_02750740211050577 for Walking the Talk of Social Equity? Street-Level Bureaucrats’ Decisionmaking About the Provision of Personal Resources by Einat Lavee in The American Review of Public Administration
Additional file 1 of Long-term effects of abatacept on atherosclerosis and arthritis in older vs. younger patients with rheumatoid arthritis: 3-year results of a prospective, multicenter, observational study
Creators: name: Yamada, Zento
name: Muraoka, Sei
name: Kawazoe, Mai
name: Hirose, Wataru
name: Kono, Hajime
name: Yasuda, Shinsuke
name: Sugihara, Takahiko
name: Nanki, Toshihiro
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Supplementary Material 1
Supplementary Material - Supplemental material for Development and Validation of a Syndrome Definition for Suspected Nonfatal Unintentional/Undetermined Intent Stimulant-Involved Overdoses
Creators: name: Pickens, Cassandra M.
name: Scholl, Lawrence
name: Liu, Stephen
name: Smith, Herschel
name: Snodgrass, Stephanie
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, Supplementary Material, for Development and Validation of a Syndrome Definition for Suspected Nonfatal Unintentional/Undetermined Intent Stimulant-Involved Overdoses by Cassandra M. Pickens, Lawrence Scholl, Stephen Liu, Herschel Smith and Stephanie Snodgrass in Public Health Reports
Pedotransfer Functions for Soil Protein Based on Random Forest Modeling for Routine Soil Health Analysis
Creators: name: Amsili, Joseph P.
name: van Es, Harold M.
name: Schindelbeck, Robert R.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: Autoclaved-citrate extractable soil protein (ACE protein, hereafter referred as “soil protein”) is a novel biological soil health indicator that can indirectly capture a soil’s capacity to supply nitrogen (N) but is relatively expensive to assess. To explore cost saving options, a dataset of 4,171 soil samples with texture, total carbon (C) and N, carbon-to-nitrogen ratio (C/N), soil protein, permanganate-oxidizable carbon (POXC), pH, and extractable magnesium (Mg) and iron (Fe), was used to develop three pedotransfer functions for soil protein. These included a full random forest (RF) model utilizing all variables, and a reduced RF model and a multiple linear regression model employing a subset of the variables. Models were validated using a US subset of the North American Project to Evaluate Soil Health Measurements dataset that contained 1,406 samples. The full RF model for soil protein reduced the root mean square error (RMSE) by 41.7 and 53.4% compared to reduced RF and multiple linear regression models, respectively. Total C was a more important variable in the model than total N. Additionally, POXC, sand, clay, and extractable Mg and Fe were found to be important in the model. Soil protein was sensitive to management at 36 of 57 long-term experiments. The full RF model was able to replicate 92% of those significant effects of management on soil protein. The new RF pedotransfer function for soil protein can improve prediction compared to traditional regression techniques and reduce the cost of comprehensive soil health assessment.
sj-docx-1-wmr-10.1177_0734242X211052846 – Supplemental material for Application of artificial intelligence to enhance collection of E-waste: A potential solution for household WEEE collection and segregation in India
Creators: name: Shreyas Madhav, AV
name: Rajaraman, Raghav
name: Harini, S
name: Kiliroor, Cinu C
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies

description: Supplemental material, sj-docx-1-wmr-10.1177_0734242X211052846 for Application of artificial intelligence to enhance collection of E-waste: A potential solution for household WEEE collection and segregation in India by AV Shreyas Madhav, Raghav Rajaraman, S Harini and Cinu C Kiliroor in Waste Management & Research
Additional file 2 of Long-term effects of abatacept on atherosclerosis and arthritis in older vs. younger patients with rheumatoid arthritis: 3-year results of a prospective, multicenter, observational study
Creators: name: Yamada, Zento
name: Muraoka, Sei
name: Kawazoe, Mai
name: Hirose, Wataru
name: Kono, Hajime
name: Yasuda, Shinsuke
name: Sugihara, Takahiko
name: Nanki, Toshihiro
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Supplementary Material 2