cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Severe Maternal Morbidity According to Mode of Delivery Among Pregnant Patients With Cardiomyopathies
Creators: name: Krishnamoorthy, Vijay
name: Quist-Nelson, Johanna
name: Shah, Svati H
name: Meng, Marie-Louise
name: Fuller, Matthew
name: Federspiel, Jerome J
name: McNeil, Ashley
name: Habib, Ashraf S
name: Engelhard, Matthew
Publisher: name: Elsevier
Year: 2023

description:
BACKGROUND: Women with cardiomyopathies are at risk for pregnancy complications. The optimal mode of delivery in these patients is guided by expert opinion and limited small studies. OBJECTIVES: The objective of this study is to examine the association of delivery mode with severe maternal morbidity events during delivery hospitalization and readmissions among patients with cardiomyopathies. METHODS: The Premier inpatient administrative database was used to conduct a retrospective cohort study of pregnant patients with a diagnosis of a cardiomyopathy. Utilizing a target trial emulation strategy, the primary analysis compared outcomes among patients exposed to intended vaginal delivery vs intended cesarean delivery (intention to treat). A secondary analysis compared outcomes among patients who delivered vaginally vs by cesarean (as-treated). Outcomes examined were nontransfusion severe maternal morbidity during the delivery hospitalization, blood transfusion, and readmission. RESULTS: The cohort consisted of 2,921 deliveries. In the primary analysis (intention to treat), there was no difference in nontransfusion morbidity (adjusted OR [aOR]: 1.17; 95% CI: 0.91-1.51), blood transfusion (aOR: 1.27; 95% CI: 0.81-1.98), or readmission (aOR: 1.03; 95% CI: 0.73-1.44) between intended vaginal delivery and intended cesarean delivery. In the as-treated analysis, cesarean delivery was associated with a 2-fold higher risk of nontransfusion morbidity (aOR: 2.44; 95% CI: 1.85-3.22) and blood transfusion (aOR: 2.26; 95% CI: 1.34-3.81) when compared with vaginal delivery. CONCLUSIONS: In patients with cardiomyopathies, a trial of labor does not confer a higher risk of maternal morbidity, blood transfusion, or readmission compared with planned cesarean delivery.
DS_10.1177_0022034520902128 – Supplemental material for Improving Oral Cancer Outcomes with Imaging and Artificial Intelligence
Creators: name: B. Ilhan
name: K. Lin
name: P. Guneri
name: P. Wilder-Smith
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine
subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, DS_10.1177_0022034520902128 for Improving Oral Cancer Outcomes with Imaging and Artificial Intelligence by B. Ilhan, K. Lin, P. Guneri and P. Wilder-Smith in Journal of Dental Research
Communicating Science Through Press Releases to News Media: The Case Study of What Is Controlling the Fabled Water Clarity of Lake Tahoe
Creators: name: Melack, John
name: Nava, Veronica
name: Paerl, Hans W.
name: Suenaga, Erin
name: Coil, John
name: Priscu, John C.
name: Chandra, Sudeep
name: Bess, Zach
name: Goldman, Charles R.
name: Lovejoy, Connie
name: Brett, Michael T.
Publisher: name: Wiley
Year: 2023

description:
Transparent scientific discourse creates public trust of science and thus may support the use of science to develop policies to protect the environment. Scientific discourse commonly proceeds through independent peer review leading to scientific manuscripts that may guide management actions. Prior to peer review, institutions may release information via press releases which may be circulated near verbatim by news organizations and social media; these organizations have demands to produce content in a timely manner (Autzen 2014). If later found to be inaccurate, the resulting dissemination of information can impact public trust and alter science priorities to address environmental challenges.
Appendix_B_Demo_using_CAT – Supplemental material for Capturing Team Dynamics in the Wild: The Communication Analysis Tool
Creators: name: Klonek, Florian E.
name: Meinecke, Annika L.
name: Hay, Georgia
name: Parker, Sharon K.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 10105 Group Theory and Generalisations
subject: FOS: Mathematics
subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business

description: Supplemental material, Appendix_B_Demo_using_CAT for Capturing Team Dynamics in the Wild: The Communication Analysis Tool by Florian E. Klonek, Annika L. Meinecke, Georgia Hay and Sharon K. Parker in Small Group Research
Opportunities, challenges, and future directions for simulation modeling the effects of structural racism on cancer mortality in the United States: a scoping review
Creators: name: Ogunsina, Kemi
name: Ish, Jennifer L
name: Kamil, Dalya
name: Le, Randy
name: Ezeani, Adaora
name: Woo, Jennifer M P
name: Cohen, Camryn M
name: Fernandez, Jessica R
name: Kefi, Safa El
name: Butera, Gisela
name: Lewis-Thames, Marquita W
name: Dash, Chiranjeev
name: Wojcik, Kaitlyn M
name: Bhattacharya, Manami
name: Chang, Che-Jung
name: Ramanathan, Amrita L
name: Jayasekera, Jinani
name: Grant, Shakira J
name: Bethea, Traci N
name: Chapman, Christina
name: Forde, Allana T
name: Ponce, Stephanie
name: Zhang, Julia
Publisher: name: Oxford University Press (OUP)
Year: 2023

description:
PURPOSE: Structural racism could contribute to racial and ethnic disparities in cancer mortality via its broad effects on housing, economic opportunities, and health care. However, there has been limited focus on incorporating structural racism into simulation models designed to identify practice and policy strategies to support health equity. We reviewed studies evaluating structural racism and cancer mortality disparities to highlight opportunities, challenges, and future directions to capture this broad concept in simulation modeling research. METHODS: We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses-Scoping Review Extension guidelines. Articles published between 2018 and 2023 were searched including terms related to race, ethnicity, cancer-specific and all-cause mortality, and structural racism. We included studies evaluating the effects of structural racism on racial and ethnic disparities in cancer mortality in the United States. RESULTS: A total of 8345 articles were identified, and 183 articles were included. Studies used different measures, data sources, and methods. For example, in 20 studies, racial residential segregation, one component of structural racism, was measured by indices of dissimilarity, concentration at the extremes, redlining, or isolation. Data sources included cancer registries, claims, or institutional data linked to area-level metrics from the US census or historical mortgage data. Segregation was associated with worse survival. Nine studies were location specific, and the segregation measures were developed for Black, Hispanic, and White residents. CONCLUSIONS: A range of measures and data sources are available to capture the effects of structural racism. We provide a set of recommendations for best practices for modelers to consider when incorporating the effects of structural racism into simulation models.
Inequalities in urban greenness and epigenetic aging: Different associations by race and neighborhood socioeconomic status
Creators: name: Nieuwenhuijsen, Mark J
name: Vaughan, Douglas E
name: Nannini, Drew R
name: Zhang, Kai
name: Shikany, James M
name: Joyce, Brian T
name: Gordon-Larsen, Penny
name: Lloyd-Jones, Donald M
name: Hu, Ming
name: Kim, Kyeezu
name: Zheng, Yinan
name: Hou, Lifang
Publisher: name: American Association for the Advancement of Science (AAAS)
Year: 2023

description:
Slower epigenetic aging is associated with exposure to green space (greenness); however, the longitudinal relationship has not been well studied, particularly in minority groups. We investigated the association between 20-year exposure to greenness [Normalized Difference Vegetation Index (NDVI)] and epigenetic aging in a large, biracial (Black/white), U.S. urban cohort. Using generalized estimating equations adjusted for individual and neighborhood socioeconomic characteristics, greater greenness was associated with slower epigenetic aging. Black participants had less surrounding greenness and an attenuated association between greenness and epigenetic aging [βNDVI5km: -0.80, 95% confidence interval (CI): -4.75, 3.13 versus βNDVI5km: -3.03, 95% CI: -5.63, -0.43 in white participants]. Participants in disadvantaged neighborhoods showed a stronger association between greenness and epigenetic aging (βNDVI5km: -3.36, 95% CI: -6.65, -0.08 versus βNDVI5km: -1.57, 95% CI: -4.12, 0.96 in less disadvantaged). In conclusion, we found a relationship between greenness and slower epigenetic aging, and different associations by social determinants of health such as race and neighborhood socioeconomic status.
Race-Based Care and Beliefs Regarding the Etiology of Racial Differences in Health Outcomes
Creators: name: Bonham, Vence L
name: Persaud, Anitra
name: Okah, Ebiere
name: Crow, Brendan
name: Cronholm, Peter F
name: Westby, Andrea
Publisher: name: Elsevier
Year: 2023

description:
INTRODUCTION: Physicians' perspectives regarding the etiology of racial health differences may be associated with their use of race in clinical practice (race-based practice). This study evaluates whether attributing racial differences in health to genetics, culture, or social conditions is associated with race-based practice. METHODS: This is a cross-sectional analysis, conducted in 2022, of the Council of Academic Family Medicine Education Research Alliance 2021 general membership survey. Only actively practicing U.S. physicians were included. The survey included demographic questions; the Racial Attributes in Clinical Evaluation (RACE) scale (higher scores imply greater race-based practice); and 3 questions regarding beliefs that racial differences in genetics, culture (e.g., health beliefs), or social conditions (e.g., education) explained racial differences in health. Three multivariable linear regressions were used to evaluate the relationship between RACE scores and beliefs regarding the etiology of racial differences in health. RESULTS: Of the 4,314 survey recipients, 949 (22%) responded, of whom 689 were actively practicing U.S. physicians. In multivariable regressions controlling for age, gender, race, ethnicity, and practice characteristics, a higher RACE score was associated with a greater belief that differences in genetics (β=3.57; 95% CI=3.19, 3.95) and culture (β=1.57; 95% CI=0.99, 2.16)-in but not social conditions-explained differences in health. CONCLUSIONS: Physicians who believed that genetic or cultural differences between racial groups explained racial differences in health outcomes were more likely to use race in clinical care. Further research is needed to determine how race is differentially applied in clinical care on the basis of the belief in its genetic or cultural significance.
Supplementary1_Holocene – Supplemental material for Decadal high-resolution multi-proxy analysis to reconstruct natural and human-induced environmental changes over the last 1350 cal. yr BP in the Altai Tavan Bogd National Park, western Mongolia
Creators: name: Unkelbach, Julia
name: Kashima, Kaoru
name: Gaadan Punsalpaamuu
name: Shumilovskikh, Lyudmila
name: Behling, Hermann
Publisher: name: SAGE Journals
Year: 2020
Subjects: Geography
History

description: Supplemental material, Supplementary1_Holocene for Decadal high-resolution multi-proxy analysis to reconstruct natural and human-induced environmental changes over the last 1350 cal. yr BP in the Altai Tavan Bogd National Park, western Mongolia by Julia Unkelbach, Kaoru Kashima, Gaadan Punsalpaamuu, Lyudmila Shumilovskikh and Hermann Behling in The Holocene
“Mm-hm,” “Uh-uh”: are non-lexical conversational sounds deal breakers for the ambient clinical documentation technology?
Creators: name: Zheng, Kai
name: Tai-Seale, Ming
name: Reynolds, Tera L
name: Tran, Brian D
name: Lafata, Jennifer Elston
name: Latif, Kareem
name: Park, Jihyun
Publisher: name: Oxford University Press (OUP)
Year: 2023

description:
OBJECTIVES: Ambient clinical documentation technology uses automatic speech recognition (ASR) and natural language processing (NLP) to turn patient-clinician conversations into clinical documentation. It is a promising approach to reducing clinician burden and improving documentation quality. However, the performance of current-generation ASR remains inadequately validated. In this study, we investigated the impact of non-lexical conversational sounds (NLCS) on ASR performance. NLCS, such as Mm-hm and Uh-uh, are commonly used to convey important information in clinical conversations, for example, Mm-hm as a "yes" response from the patient to the clinician question "are you allergic to antibiotics?" MATERIALS AND METHODS: In this study, we evaluated 2 contemporary ASR engines, Google Speech-to-Text Clinical Conversation ("Google ASR"), and Amazon Transcribe Medical ("Amazon ASR"), both of which have their language models specifically tailored to clinical conversations. The empirical data used were from 36 primary care encounters. We conducted a series of quantitative and qualitative analyses to examine the word error rate (WER) and the potential impact of misrecognized NLCS on the quality of clinical documentation. RESULTS: Out of a total of 135 647 spoken words contained in the evaluation data, 3284 (2.4%) were NLCS. Among these NLCS, 76 (0.06% of total words, 2.3% of all NLCS) were used to convey clinically relevant information. The overall WER, of all spoken words, was 11.8% for Google ASR and 12.8% for Amazon ASR. However, both ASR engines demonstrated poor performance in recognizing NLCS: the WERs across frequently used NLCS were 40.8% (Google) and 57.2% (Amazon), respectively; and among the NLCS that conveyed clinically relevant information, 94.7% and 98.7%, respectively. DISCUSSION AND CONCLUSION: Current ASR solutions are not capable of properly recognizing NLCS, particularly those that convey clinically relevant information. Although the volume of NLCS in our evaluation data was very small (2.4% of the total corpus; and for NLCS that conveyed clinically relevant information: 0.06%), incorrect recognition of them could result in inaccuracies in clinical documentation and introduce new patient safety risks.
supporting_information – Supplemental material for A new lignan from Schefflera arboricola
Creators: name: Ye, Chang-Qing
name: Zhang, Jia-Yi
name: Ye, Zhi-Cheng
name: Xiao, Mei-Tian
name: Zhou, Xu-Dong
name: Ye, Jing
Publisher: name: SAGE Journals
Year: 2020
Subjects: Materials Engineering not elsewhere classified

description: Supplemental material, supporting_information for A new lignan from Schefflera arboricola by Chang-Qing Ye, Jia-Yi Zhang, Zhi-Cheng Ye, Mei-Tian Xiao, Xu-Dong Zhou and Jing Ye in Journal of Chemical Research
Global carbon uptake of cement carbonation accounts 1930–2021
Creators: name: Niu, Le
name: Friedlingstein, Pierre
name: Yu, Ying
name: Qiu, Yijiao
name: Xi, Fengming
name: Huang, Zi
name: Wang, Jiaoyue
name: Liu, Zhu
name: Guo, Rui
name: Tong, Dan
name: Bing, Longfei
name: Ma, Mingjing
name: Canadell, Josep G.
name: Andrew, Robbie M.
Publisher: name: Copernicus Publications
Year: 2023

description:
The main contributor to the greenhouse gas (GHG) footprint of the cement industry is the decomposition of alkaline carbonates during clinker production. However, systematic accounts for the reverse of this process – namely carbonation of calcium oxide and other alkaline oxides and/or hydroxides within cement materials during cements' life cycles – have only recently been undertaken. Here, adopting a comprehensive analytical model, we provide the most updated estimates of CO2 uptake by cement carbonation. The accumulated amount of global CO2 uptake by cements produced from 1930 to 2021 is estimated to be 22.9 Gt CO2 (95 % confidence interval, CI: 19.6–26.6 Gt CO2). This amount includes the CO2 uptake by concrete, mortar, construction waste and kiln dust, accounting for 30.1 %, 58.5 %, 4.0 % and 7.1 % respectively. The cumulative carbon uptake by cement materials from 1930 to 2021 offsets 55.1 % of the emissions from cement production (41.6 Gt CO2, 95 % CI: 38.7–47.2 Gt CO2) over the same period, with the greater part coming from mortar (58.5 % of the total uptake). China has the highest cement carbon uptake, with cumulative carbonation of 7.06 Gt CO2 (95 % CI: 5.22–9.44 Gt CO2) since 1930. In addition, the carbon uptake amounts of the USA, EU, India and the rest of the world took 5.0 %, 23.2 %, 5.6 % and 34.8 % separately. As a result of rapidly increased production in recent years, over three-quarters of the cement carbon uptake has occurred since 1990. Additionally, our results show little impact by the COVID-19 pandemic on cement production and use, with carbon uptake reaching about 0.92 Gt CO2 (95 % CI: 0.78–1.10 Gt CO2) in 2020 and 0.96 Gt CO2 (95 % CI: 0.81–1.15 Gt CO2) in 2021. Our uniformly formatted and most updated cement uptake inventories provide coherent data-based support for including cement carbon uptake into future carbon budgets from the local to global scale. The latest version contains the uptake data till 2021, showing the global uptake's increasing pattern and offering more usable and relevant data for evaluating cement's carbon uptake capacity. All the data described in this study are accessible at https://doi.org/10.5281/zenodo.7516373 (Bing et al., 2023).
Electronic_supporting_Information – Supplemental material for A derivatization-directed three-component synthesis of fluorescent spiro [dihydropyridine-4,3ʹ-indoline]s
Creators: name: Faranak Najafizadeh
name: Kurosh Rad-Moghadam
name: Kalurazi, Soraya Yaghoubi
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, Electronic_supporting_Information for A derivatization-directed three-component synthesis of fluorescent spiro [dihydropyridine-4,3ʹ-indoline]s by Faranak Najafizadeh, Kurosh Rad-Moghadam and Soraya Yaghoubi Kalurazi in Journal of Chemical Research
Applications of Artificial Intelligence in the Automatic Diagnosis of Focal Liver Lesions: A Systematic Review.
Creators: name: Masier, Annalisa
name: Popa, Stefan Lucian
name: Peserico, Giulia
name: Fantin, Alberto
name: Grad, Simona
name: Brata, Vlad Dumitru
name: Chiarioni, Giuseppe
name: Dumitrascu, Dinu Iuliu
Publisher: name: Romanian Society of Gastroenterology and Hepatology
Year: 2023

description:
BACKGROUND AND AIMS: Focal liver lesions (FLLs) are defined as abnormal solid or liquid masses differentiated from normal liver, frequently being clinically asymptomatic. The aim of this systematic review is to provide a comprehensive overview of current artificial intelligence (AI) applications, deep learning systems and convolutional neural networks, capable of performing a completely automated diagnosis of FLLs. METHODS: We searched PubMed, Cochrane Library, EMBASE, and WILEY databases using predefined keywords. Articles were screened for relevant publications about AI applications capable of automated diagnosis of FLLs. The search terms included: (focal liver lesions OR FLLs OR hepatic focal lesions OR liver focal lesions OR liver tumor OR hepatic tumor) AND (artificial intelligence OR machine learning OR neural networks OR deep learning OR automated diagnosis OR ultrasound OR US OR computer scan OR CT OR magnetic resonance imaging OR MRI OR computer-aided diagnosis OR automated computer tomography OR automated magnetic imaging). RESULTS: Our search identified a total of 32 articles analyzing complete automated imagistic diagnosis of FLLs, out of which 14 studies analyzing liver ultrasound images, 8 studies analyzing computer tomography images and 10 studies analyzing images obtained from magnetic resonance imaging. CONCLUSIONS: We found significant evidence demonstrating that implementing a complete automated system for FLLs diagnosis using AI-based applications is currently feasible. Various automated AI-based applications have been analyzed. However, there is no clear evidence about the superiority of any of the systems.
PBH_Journal_V3_Paper_04_Extinction-Studies.pdf
Creators: name: Ferwerda, Susanne
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 470209
subject: Environment and culture
classificationCode: 360603
subject: Performance art
classificationCode: 360602
subject: Fine arts

description: When an image is erased, what is lost and what remains? On September 6, 2019, Australian graphic artist Lucienne Rickard started a twelve-month duration performance called Extinction Studies . Each day, with pencil on a single piece of paper, she draws a recently extinct species, only to erase it as soon as its image is complete. The performance takes place at the Tasmanian Museum and Art Gallery (TMAG), a location saturated with histories of local mass extinction events. Two rooms away from Rickard’s performance, another exhibition shows the bones, skins and some of the last known images of the Tasmanian tiger (Thylacinus cynocephalus). The juxtaposition of these two exhibitions draws out the relationship between extinction and the act of erasing. This paper examines the affective nature of erasure and extinction. Rickard’s care for each line she draws and erases, reinforces the physical and emotional investment that twenty-first-century extinction events compel. The difference between the two exhibitions is one of scale and time. Where the permanent thylacine exhibition performs the long durée of erasure and ‘extinction afterlives’ of a single species thought lost since 1936, Extinction Studies simultaneously shows the fast-paced acts of erasure of many species thought lost since the turn of the twenty-first-century.
JOM-18-0705.R4_Supplemental_Appendix – Supplemental material for Metacritiques of Upper Echelons Theory: Verdicts and Recommendations for Future Research
Creators: name: Neely, Brett H.
name: Lovelace, Jeffrey B.
name: Cowen, Amanda P.
name: Hiller, Nathan J.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business

description: Supplemental material, JOM-18-0705.R4_Supplemental_Appendix for Metacritiques of Upper Echelons Theory: Verdicts and Recommendations for Future Research by Brett H. Neely, Jeffrey B. Lovelace, Amanda P. Cowen and Nathan J. Hiller in Journal of Management
Artificial Intelligence in Sports Medicine: Could GPT-4 Make Human Doctors Obsolete?
Creators: name: He, Yongbin
name: Wu, Haiyang
name: Xie, Ruijie
name: Lu, Yanqiu
name: Cheng, Kunming
name: Li, Cheng
name: Guo, Qiang
Publisher: name: Springer Nature
Year: 2023

description:
Sports medicine, an essential branch of orthopedics, focuses on preserving, restoring, improving, and rebuilding the function of the human motor system. As a thriving interdisciplinary field, sports medicine attracts not only the interest of the orthopedic community, but also artificial intelligence (AI). In this study, our team summarized the potential applications of GPT-4 in sports medicine including diagnostic imaging, exercise prescription, medical supervision, surgery treatment, sports nutrition, and science research. In our opinion, it is impossible that GPT-4 could make sports physicians obsolete. Instead, it could become an indispensable scientific assistant for sport doctors in future.
Artificial intelligence meets medical robotics
Creators: name: Opfermann, Justin D
name: Salcudean, Septimiu
name: Krieger, Axel
name: Yip, Michael
name: Goldberg, Ken
name: Huang, He Helen
name: Althoefer, Kaspar
name: Walsh, Conor J
name: Lee, I-Chieh
name: Menciassi, Arianna
name: Swaminathan, Krithika
Publisher: name: American Association for the Advancement of Science (AAAS)
Year: 2023

description:
Artificial intelligence (AI) applications in medical robots are bringing a new era to medicine. Advanced medical robots can perform diagnostic and surgical procedures, aid rehabilitation, and provide symbiotic prosthetics to replace limbs. The technology used in these devices, including computer vision, medical image analysis, haptics, navigation, precise manipulation, and machine learning (ML) , could allow autonomous robots to carry out diagnostic imaging, remote surgery, surgical subtasks, or even entire surgical procedures. Moreover, AI in rehabilitation devices and advanced prosthetics can provide individualized support, as well as improved functionality and mobility (see the figure). The combination of extraordinary advances in robotics, medicine, materials science, and computing could bring safer, more efficient, and more widely available patient care in the future. -Gemma K. Alderton.
Prognostic and molecular multi-platform analysis of CALGB 40603 (Alliance) and public triple-negative breast cancer datasets
Creators: name: Fernandez-Martinez, Aranzazu
name: Perou, Charles M.
name: Felsheim, Brooke M.
name: Sikov, William M.
name: Carey, Lisa A.
name: Somlo, George
name: Tolaney, Sara M.
name: Hayward, Michele C.
name: Rashid, Naim U.
name: Pfefferle, Adam D.
name: Hoadley, Katherine A.
name: Fan, Cheng
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2025

description:
Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous disease that remains challenging to target with traditional therapies and to predict risk. We provide a comprehensive characterization of 238 stage II-III TNBC tumors with paired RNA and DNA sequencing data from the CALGB 40603 (Alliance) clinical trial, along with 448 stage II-III TNBC tumors with paired RNA and DNA data from three additional datasets. We identify DNA mutations associated with RNA-based subtypes, specific TP53 missense mutations compatible with potential neoantigen activity, and a consistently highly altered copy number landscape. We train exploratory multi-modal elastic net models of TNBC patient overall survival to determine the added impact of DNA-based features to RNA and clinical features. We find that mutations and copy number show little to no prognostic value, while RNA expression features, including signatures of T cell and B cell activity, along with stage, improve stratification of TNBC survival risk.
Supplementary_Figures - The Impact of Limbal Mesenchymal Stromal Cells on Healing of Acute Ocular Surface Wounds is Improved by Pre-cultivation and Implantation in the Presence of Limbal Epithelial Cells
Creators: name: Nili, Elham
name: Li, Fiona J.
name: Dawson, Rebecca A.
name: Lau, Cora
name: McEwan, Blair
name: Barnett, Nigel L.
name: Weier, Steven
name: Walshe, Jennifer
name: Richardson, Neil A.
name: Harkin, Damien G.
Publisher: name: SAGE Journals
Year: 2019
Subjects: Medicine
Cell Biology

description: Supplementary_Figures for The Impact of Limbal Mesenchymal Stromal Cells on Healing of Acute Ocular Surface Wounds is Improved by Pre-cultivation and Implantation in the Presence of Limbal Epithelial Cells by Elham Nili, Fiona J. Li, Rebecca A. Dawson, Cora Lau, Blair McEwan, Nigel L. Barnett, Steven Weier, Jennifer Walshe, Neil A. Richardson and Damien G. Harkin in Cell Transplantation
Connectome-wide Brain Signature During Fast Food Advertisement Exposure Predicts BMI At 2 Years
Creators: name: Shearrer, Grace E
name: Meyer, Katie A
name: Finn, Emily S
name: Taillie, Lindsey Smith
name: Gearhardt, Ashley N
name: Shaikh, Saame Raza
name: Yokum, Sonja
name: Hoover, Lindzey V
name: Burger, Kyle S
name: Papantoni, Afroditi
Publisher: name: Oxford University Press (OUP)
Year: 2025

description:
Food advertisements target adolescents contributing to weight gain and obesity. However, whether brain connectivity during those food advertisements can predict weight gain is unknown. Here, 121 adolescents (14.1±1.0y; 50.4% female; BMI: 23.4±4.8; 71.9% White) completed both a baseline fMRI paradigm viewing advertisements (unhealthy fast-food, healthier fast-food, and non-food) and an anthropometric assessment two years later. We used connectome-based predictive modeling (CPM) to derive brain networks that were associated with BMI both at baseline and the 2-year follow-up. During exposure to unhealthy fast-food commercials, we identified a brain network comprising high-degree nodes in the hippocampus, parahippocampal, and fusiform gyrus rich with connections to prefrontal and occipital nodes that predicted lower BMI at 2-year follow-up (r =0.17; p=0.031). A similar network was derived from baseline BMI (n=168; r =0.34; p<0.001). Functional connectivity networks during exposure to the healthier fast-food (p=0.152) and non-food commercials (p=0.117) were not significant predictors of 2-year BMI. Key brain regions in our derived networks have been previously shown to encode aspects of memory formation, visual processing, and self-control. As such, the integration of these regions may reflect a mechanism of adolescents’ ability to exert self-control towards obesogenic food stimuli.
IPS_Supp_Online_Appendix – Supplemental material for Building impartial electoral management? Institutional design, independence and electoral integrity
Creators: name: James, Toby S
name: Garnett, Holly Ann
name: Loeber, Leontine
name: Ham, Carolien Van
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 160607 International Relations
subject: FOS: Political science

description: Supplemental material, IPS_Supp_Online_Appendix for Building impartial electoral management? Institutional design, independence and electoral integrity by Toby S James, Holly Ann Garnett, Leontine Loeber, Carolien van Ham, Carolien van Ham and Holly Ann Garnett in International Political Science Review
Effector CD8 T cell differentiation in primary and breakthrough SARS-CoV-2 infection in mice
Creators: name: Baric, Ralph C.
name: Sullivan, Jeremy A.
name: Park, Hongtae
name: Lee, Woojong
name: Kingstad-Bakke, Brock
name: Cleven, Thomas
name: Yount, Boyd L.
name: Suresh, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2025

description:
The nature of the effector and memory T cell response in the lungs following acute SARS-CoV-2 infections remains largely unknown. To define the pulmonary T-cell response to COVID-19, we compared effector and memory T-cell responses to SARS-CoV-2 and influenza A virus (IAV) in mice. Both viruses elicited potent effector T cell responses in lungs, but memory T cells showed exaggerated contraction in SARS-CoV-2-infected mice. Specifically, unlike the T-bet/EOMES-driven effector transcription program in IAV lungs, SARS-CoV-2-specific CD8 T cells embarked on a STAT-3-centric transcriptional program, a defining characteristic of a pro-fibro-inflammatory program: limited cytotoxicity, diminished expression of tissue-protective inhibitory receptors (PD-1, LAG-3, and TIGIT), and augmented mucosal imprinting (CD103). Circulating CD45RO+HLA-DR+ CD8 T cells in hospitalized COVID-19 patients expressed elevated levels of STAT-3 and low levels of TIGIT. IL-6 blockade experiments implicated IL-6 in STAT-3 induction and downregulation of PD-1 expression on SARS-CoV-2-specific primary effector CD8 T cells. Memory CD8 T cells specific to a single epitope, induced by mucosal vaccination, differentiated into cytotoxic effectors and expressed high levels of CD103, effectively reducing viral burden in lungs following a breakthrough SARS-CoV-2 infection. Our findings have implications for developing targeted immunotherapies to mitigate immunopathology and promote protective T cell immunity to SARS-CoV-2.
Sleep and Cancer
Creators: name: Vaughn, Courtney M.
name: Vaughn, Bradley V.
Publisher: name: MDPI
Year: 2025

description:
Background/Objectives: Sleep issues are common in the general population, and these problems occur even more frequently for people with cancer. Sleep problems may pre-exist a patient’s cancer diagnosis, and there is a growing interest in understanding the impact of sleep on cancer development and progression. Sleep disorders may impact cancer through altered metabolism, impacts on immune response, and alterations in hormones and gene expression. Sleep disorders may also arise after, or be aggravated by, an individual’s cancer and cancer treatment. Treating a person with cancer’s sleep disorder may help improve their healing, mental health, cognition, and overall resilience. Methods: Studies examining a variety of aspects of the relationship between sleep and cancer were found by searching the National Library of Medicine and characterized by their specific information provided on the relationship between sleep and cancer. Results: This review article summarizes our current understanding of the complex inter-relationship between sleep and cancer, the underlying mechanisms that create these connections, and the methods and impact of treating sleep issues in cancer patients. The article also outlines an approach to sleep complaints for clinicians caring for patients with cancer. Conclusions: Significant research is still needed to understand the full relationship between sleep disorders and cancer. The impact of sleep issues on cancer and of cancer on sleep appears to be specific to the tissue and the molecular type of cancer. The treatment of sleep disorders is multimodal, and offers a promising avenue to improve the health and quality of life of cancer patients.
Acceptability and feasibility of acceptance and commitment therapy for improving outcomes in hematopoietic stem cell transplant.
Creators: name: Infield, Jordan
name: Hill, Lauren
name: Winthrop, Hilary
name: Smith, Patrick J
name: Riley, J A
name: Moskovich, Ashley A
name: Sung, Anthony D
name: Bush, Amy
name: Merwin, Rhonda M
name: Mayo, Dorothy
name: Johnson, Ernaya
name: Scheiber, Francesca
name: O'Connell, Christine
Publisher: name: Public Library of Science (PLoS)
Year: 2025

description:
INTRODUCTION: Allogeneic hematopoietic stem cell transplant (HCT) has the potential to cure patients with hematologic malignancies, but treatment-related morbidity and mortality is high. Transplant outcomes are optimized by patients maintaining physical activity. The aim of the current study was to examine whether a brief Acceptance and Commitment Therapy (ACT) intervention is acceptable to HCT patients and caregivers and helps patients engage in healthy behavior despite physical and emotional discomfort. METHODS: Patients ≥ 18 years of age who were undergoing allogenic HCT for any cancer or non-cancer illness and their caregivers were invited to complete six ACT sessions between transplant day - 30 and day + 90. Multiple small cohorts of n = 3 dyads were enrolled, and the protocol content was iterated after each cohort to reflect the experiences and breadth of concerns of individuals undergoing HCT. Acceptability was indexed by session completion rates and acceptability surveys. Pre-post 6-minute walk distance was collected as an index of physical function as part of standard care. RESULTS: Sixteen HCT dyads enrolled in the study; 12 continued to treatment. Most participants completed all assigned sessions. Participants perceived ACT to be helpful and 70% (5 of 7) of the patients with pre-post 6-minute walk test data showed improvement. CONCLUSION: ACT is an acceptable and potentially useful intervention for individuals undergoing HCT. Additional controlled studies are warranted.
Extravascular coagulation regulates haemostasis independently of activated platelet surfaces in an in vivo mouse model
Creators: name: Okuyama-Nishida, Yukiko
name: Harada, Suguru
name: Matsumoto, Naoki
name: Kawasaki, Ryohei
name: Shima, Midori
name: Soeda, Tetsuhiro
name: Sakata, Asuka
name: Mackman, Nigel
name: Nogami, Keiji
name: Tatsumi, Kohei
Publisher: name: Springer Nature
Year: 2025

description:
While the conventional understanding of haemostatic plug formation is that coagulation proceeds efficiently on the surface of activated platelets at the vascular injury site to form a robust haemostatic plug, this understanding does not explain the clinical reality that platelet dysfunction results in a mild bleeding phenotype, whereas coagulation disorders exhibit severe bleeding phenotypes, particularly in deep tissues. Here, we introduce an in vivo imaging method to observe internal bleeding and subsequent haemostatic plug formation in mice and report that haemostatic plug formation after internal bleeding, coagulation occurs primarily outside the blood vessel rather than on platelets. Experiments in mice with impaired platelet surface coagulation, depleted platelets, haemophilia A or reduced tissue factor expression suggest that this extravascular coagulation triggers and regulates haemostatic plug formation. Our discovery of the important role of extravascular coagulation in haemostasis may contribute to refining the treatment of haemostatic abnormalities and advancing antithrombotic therapy.
Evaluation of enzyme activity predictions for variants of unknown significance in Arylsulfatase A
Creators: name: Pucci, Fabrizio
name: Glagovsky, Ailin
name: Joshi, Dinesh
name: Pejaver, Vikas
name: Katsonis, Panagiotis
name: Cedillo, Luis R.
name: Trinidad, Marena
name: Srinivasan, Rajgopal
name: Pradhan, Swatantra
name: Raimondi, Daniele
name: Barrón, Laura T. Jiménez
name: de la Cruz, Xavier
name: Jones, Cameron
name: Brenner, Steven E.
name: Kwee, Sofia
name: Rahimi, Kobra
name: Kazi, Sufyan
name: Suhr, Dean
name: Shen, Yang
name: Rana, Sadhna
name: Chen, Ken
name: Padilla, Natàlia
name: Zeiberg, Daniel
name: Wang, Boqi
name: Acuna-Hidalgo, Rocio
name: Berardelli, Silvia
name: Jain, Shantanu
name: Grafmüller, Andrea
name: Velyunskiy, Michelle
name: Sun, Yuanfei
name: Kamandula, Akash
name: Sajeed, Rakshanda
name: Li, Sindy
name: Jones, Kaiya
name: Xu, Jierui
name: Cia, Gabriel
name: Babbi, Giulia
name: Jernigan, Robert
name: Long, Kinsey
name: Sterling, Teague
name: Bakolitsa, Constantina
name: Lugo-Martinez, Jose
name: Moran, Giankaleb
name: Faraggi, Eshel
name: Lichtarge, Olivier
name: Özkan, Selen
name: Nguyen, Thanh Binh
name: Clark, Wyatt T.
name: Radivojac, Predrag
name: Astore, Courtney
name: Özden, Buse
name: Ramola, Rashika
name: Casadio, Rita
name: Neto, Santiago Diaz
name: Goldstein, Jennifer L.
name: Ge, Fang
name: Manfredi, Matteo
name: Song, Zigang
name: Martelli, Pier Luigi
name: Chen, Ella
name: Williams, Amanda
name: Kloczkowski, Andrzej
name: Rooman, Marianne
name: Zhu, Shaowen
name: Savojardo, Castrense
name: Suhr, Teryn
name: Çalıcı, Sümeyra Zeynep
name: Hermans, Pauline
name: Mishra, Reet
Publisher: name: Springer Nature
Year: 2025

description:
Continued advances in variant effect prediction are necessary to demonstrate the ability of machine learning methods to accurately determine the clinical impact of variants of unknown significance (VUS). Towards this goal, the ARSA Critical Assessment of Genome Interpretation (CAGI) challenge was designed to characterize progress by utilizing 219 experimentally assayed missense VUS in the Arylsulfatase A (ARSA) gene to assess the performance of community-submitted predictions of variant functional effects. The challenge involved 15 teams, and evaluated additional predictions from established and recently released models. Notably, a model developed by participants of a genetics and coding bootcamp, trained with standard machine-learning tools in Python, demonstrated superior performance among submissions. Furthermore, the study observed that state-of-the-art deep learning methods provided small but statistically significant improvement in predictive performance compared to less elaborate techniques. These findings underscore the utility of variant effect prediction, and the potential for models trained with modest resources to accurately classify VUS in genetic and clinical research.
Supplemental_Material_ – Supplemental material for Do German Children Differ? A Validation of Conners Early Childhood™
Creators: name: Türk, Selina
name: Harbarth, Simon
name: Bergold, Sebastian
name: Steinmayr, Ricarda
name: Neidhardt, Eva
name: Kamp-Becker, Inge
name: Equit, Monika
name: Wunsch, Katja
name: Christiansen, Hanna
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: Education
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, Supplemental_Material_ for Do German Children Differ? A Validation of Conners Early Childhood™ by Selina Türk, Simon Harbarth, Sebastian Bergold, Ricarda Steinmayr, Eva Neidhardt, Inge Kamp-Becker, Monika Equit, Katja Wunsch and Hanna Christiansen in Journal of Attention Disorders
Supplementary_Appendix - The African economic growth experience and tourism receipts: A threshold analysis and quantile regression approach
Creators: name: Sahni, Herman
name: Nsiah, Christian
name: Fayissa, Bichaka
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: Economics
subject: 150402 Hospitality Management
subject: FOS: Economics and business

description: Supplementary_Appendix for The African economic growth experience and tourism receipts: A threshold analysis and quantile regression approach by Herman Sahni, Christian Nsiah and Bichaka Fayissa in Tourism Economics
Destigmatizing borderline personality disorder with social justice and intersectional cultural humility: How researchers can construct and deconstruct stigma
Creators: name: Ma, Ruofan
name: Else-Quest, Nicole M.
Publisher: name: SAGE Publications
Year: 2025

description:
Borderline personality disorder (BPD) is a serious psychiatric condition, especially stigmatized in women. Stigma is a social injustice, as it discredits and reduces the wholeness of a person to one of taint and discount. Psychological scientists play a uniquely powerful role in the stigmatization and destigmatization of BPD by constructing the meaning of BPD at each step of the research process. We discuss this powerful role and how to destigmatize BPD by incorporating an intersectionality framework that includes disability as a category of difference (as with gender, race, and sexuality). This framework centers the role of systems and structures in creating and maintaining stigma, while emphasizing the close interactions between interpersonal and structural stigma. This article illustrates researchers’ power to assign meaning to BPD in research and highlights the importance of considering individuals as embedded in intersectional social categories, which are multidimensional and dynamic in nature. We propose that intersectional cultural humility, with its social justice aim and feminist origins, can guide BPD researchers to conduct nonstigmatizing and rigorous research on BPD. To inform clinical practice and advance social justice, we offer action steps for researchers to destigmatize BPD with intersectional cultural humility at multiple steps in the research process.
Supplementary_Table – Supplemental material for Developing and Validating a Pediatric Potentially Avoidable Transfer Quality Metric
Creators: name: Rosenthal, Jennifer L.
name: Oluseun Atolagbe
name: Hamline, Michelle Y.
name: Su-Ting T. Li
name: Toney, Alexis
name: Witkowski, Jessica
name: McKnight, Heather
name: Tancredi, Daniel J.
name: Romano, Patrick S.
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, Supplementary_Table for Developing and Validating a Pediatric Potentially Avoidable Transfer Quality Metric by Jennifer L. Rosenthal, Oluseun Atolagbe, Michelle Y. Hamline, Su-Ting T. Li, Alexis Toney, Jessica Witkowski, Heather McKnight, Daniel J. Tancredi and Patrick S. Romano in American Journal of Medical Quality
Additional file 2 of Association of triglycerides to high-density lipoprotein cholesterol ratio to identify future prediabetes and type 2 diabetes mellitus: over one-decade follow-up in the Iranian population
Creators: name: Tohidi, Maryam
name: Asgari, Samaneh
name: Chary, Abdolreza
name: Safiee, Siavash
name: Azizi, Fereidoun
name: Hadaegh, Farzad
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Mathematical Sciences not elsewhere classified
subject: Hematology

description: Additional file 2. Table S2 HRs (95% CIs)* of TG/HDL-C for incident prediabetes† and T2DM†† among total population.
Coping With ‘Scanxiety’: Within-Person Processes in Lung Cancer
Creators: name: Neupert, Shevaun D.
name: Dunsmore, Victoria J.
Publisher: name: SAGE Publications
Year: 2025

description:
Background: Patients with early-stage lung cancer undergo potentially curative therapy, and continue to undergo regularly scheduled CT scans to determine if cancer has reappeared, spread, or stayed the same. This process can be fraught with anxiety, coined ‘Scanxiety’. The present study examined how coping and scan-related anxiety fluctuate within-person before one’s scan. Method: Twenty five individuals with lung cancer who had received curative intent treatment (M age = 62.33, [SD = 8.10], 96% women, 80% white) participated in the study, which had two parts. First, participants provided information about proactive coping and scan-related anxiety every 30 days. Next, a daily diary study was implemented for 7 consecutive days before their CT scan, as well as the day of their CT scan, where participants reported on their daily anticipatory coping and scan-related anxiety. The 25 participants provided 59 monthly and 146 daily surveys for analysis. Results: Multilevel models revealed significant main effects of monthly proactive coping on monthly scan-related anxiety, as well as daily anticipatory coping on daily scan-related anxiety. On months when participants decreased their use of proactive coping, they also reported decreases in scan-related anxiety for that month. On days when participants reported decreases in outcome fantasy and stagnant deliberation, they reported decreases in scan-related anxiety for that day. Finally, a significant interaction was found such that on days when middle-aged adults reported increases in problem analysis, they also reported increases in scan-related anxiety for that day. Conclusion: These findings are the first to characterize how participants’ coping and scanxiety fluctuate in the months and days prior to their CT scans. Results indicated that focusing on the present may be more beneficial in reducing scan-related anxiety rather than thinking about the future. Future work should implement strategies to reduce scanxiety by focusing on the present among those with lung cancer.
Additional file 1 of Clinicodemographic correlates of psychotic features in bipolar disorder – a multicenter study in China
Creators: name: Zhang, Zhi-Fang
name: Huang, Juan
name: Zhu, Xue-Quan
name: Yu, Xin
name: Yang, Hai-Chen
name: Xu, Xiu-Feng
name: Fang, Yi-Ru
name: Tan, Qing-Rong
name: Li, Hui-Chun
name: Wang, Gang
name: Zhang, Ling
Publisher: name: figshare
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Neuroscience
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health
subject: Hematology

description: Additional file 1: Table S1. Socio-demographic and clinical characteristics of the patients with BD I with or without psychotic symptoms. Table S2. Multivariate logistic regression analysis of bipolar I disorder with psychotic symptoms. Table S3. Socio-demographic and clinical characteristics of the patients with BD II with or without psychotic symptoms. Table S4. Multivariate logistic regression analysis of bipolar II disorder with psychotic symptoms.