cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Desmella Munro 1957
Creators: name: El-Hawagry, Magdi S.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Tephritidae
Desmella

description: Genus DESMELLA Munro
Desmella Munro, 1957: 986. Type species: Trypeta anceps Loew, 1861, original designation.
description: Published as part of El-Hawagry, Magdi S., 2017, Catalogue of Egyptian Tephritoidea (Diptera: Schizophora: Acalyptratae), pp. 151-190 in Zootaxa 4299 (2) on page 170, DOI: 10.11646/zootaxa.4299.2.1, http://zenodo.org/record/843233
Targeted manipulation of tumor-associated reactive astrocytes in glioblastoma
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Glioblastoma is the most common and aggressive primary brain cancer, with 3 - 4 cases per 100,000 people in the United States and Europe. Prognosis is poor with median survival rates of 14-16 months, and no cure is currently available. These aggressive tumors are initiated from transformed astrocytes and other glial cells, whose normal role in healthy brain function is trophic and metabolic support of neurons. Evidence suggests that tumor-associated reactive astrocytes (TAAs) feed tumor growth by secreting growth factors and inflammatory mediators. Therefore, development of new strategies to target and reprogram or eliminate TAAs could offer a unique therapeutic strategy to degrade and eliminate these tumors. Unfortunately, currently available tools cannot distinguish between the healthy supportive astrocytes in the rest of the brain from the TAAs feeding the tumor. We have recently developed a new transgenic approach to selectively target and manipulate TAAs, while leaving the healthy astrocytes intact and able to continue their normal supportive functions. Using this new tool, we will first characterize its expression in TAAs in animal models of glioblastoma already on hand in our lab. We will then perform a pilot transcriptome analysis of TAAs using fluorescence cell sorting and bulk sequencing, which will reveal uniquely altered genes in TAAs relative to healthy astrocytes and reactive astrocytes in other disease states (databases which are already available). Transcriptome analysis will reveal unique characteristics of TAAs for further study and novel targets for therapy. Last, we will selectively eliminate TAAs through targeted expression of diptheria toxin A, removing the supportive environment for tumor growth and allowing the body's natural immune response to attach and degrade the tumor. These studies have the potential to transform the field through development of translational therapies targeting tumor-associated reactive astrocytes.
The comparative immune-oncology of canine and human brain tumors designed to improve glioma outcomes
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: High-grade gliomas (HGGs) are uniformly lethal primary brain tumors of children and adults. Despite their shared aggressiveness, pediatric and adult HGGs are genetically and immunologically distinct tumors, requiring tailored, and likely independent, immunotherapeutic approaches. Anti-tumor immunotherapy has shown promising preclinical efficacy in both pediatric and adult HGG but have failed to translate into increased survival time for human patients. Thus, there is an urgent need for complementary preclinical models which more closely predict therapeutic efficacy in HGG patients. Canine HGGs, which develop de novo in an outbred, immunocompetent host, are increasingly pursued as a therapeutic model for human HGG. Similar to adult HGG, we demonstrated that canine HGG is highly inflammatory, with a robust GAM infiltrate and increased cytokine and chemokine expression. In contrast, genomic analysis indicated that canine HGG aligns closely with pediatric HGG. This discrepancy presents two challenges for canine HGG as a translational model: 1) Which therapeutic interventions are appropriate to evaluate in canine HGG, and 2) which human patient population(s) is most appropriate to translate these findings? A comprehensive analysis of the immune microenvironment is lacking in canine HGG, precluding optimized therapeutic targeting and application of canine trials to human patients. Single-cell RNA sequencing (scRNA-seq) will provide a powerful tool for a comprehensive analysis of immune cell populations in canine HGG. Based on our laboratory’s work, we hypothesize that canine HGG exhibits a heterogenous and functionally distinct immune cell infiltrate, comprised of inflammatory microglia and immunosuppressed macrophages and lymphocytes. Our proposed studies will 1) define the cellular identities and molecular signatures of canine HGG immune cells using scRNA-seq for comparison with human HGG and 2) will inform the use of therapeutic approaches in canine HGG and their subsequent translation to human patients. These data will provide necessary direction and preliminary data for a NIH R01 submission June 2023, while providing a detailed transcriptome of the aged canine CNS immune cell landscape in health and under the influence of glioma that will be made available to the scientific community.
Desmella conyzae
Creators: name: El-Hawagry, Magdi S.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Tephritidae
Desmella
Desmella conyzae

description: Desmella conyzae (Frauenfeld, 1857)
Trypeta conyzae Frauenfeld, 1857: 555. Egypt (Cairo: Esbekieh). Syntypes (NHMW). Distribution. PA: Egypt.
Egyptian localities. Coastal Strip: Abu Mena. Lower Nile Valley & Delta: Cairo, Koubba, Maadi, Mansouria. Host plants. Horseweed (Conyza aegyptiaca (L.) Aiton). Source: Efflatoun (1924a). Dates of collection. February to October.
description: Published as part of El-Hawagry, Magdi S., 2017, Catalogue of Egyptian Tephritoidea (Diptera: Schizophora: Acalyptratae), pp. 151-190 in Zootaxa 4299 (2) on page 170, DOI: 10.11646/zootaxa.4299.2.1, http://zenodo.org/record/843233
Investigating the Role of Transposable Elements During Cell Fate Commitment
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Transposable elements (TEs) are repetitive DNA regions that occupy roughly 50% of mammalian genomes. On the one hand, TEs pose a constant threat to genomic integrity due to their capacity to replicate and insert into new genomic locations. On the other hand, TEs present an important asset for gene evolution and regulation of gene expression. In higher eukaryotes, TEs are activated in the early embryo during reprogramming of the parental genomes, but then rapidly silenced and they normally remain dormant for the rest of the life of an organism. Intriguingly, TEs can become aberrantly reactivated in cancer and their activity can contribute to tumorigenesis. Therefore, it is important to understand how TEs are regulated and how their activation may affect cell fate. We and others have previously shown a critical role of chromatin assembly in silencing of TEs during reprogramming of somatic to pluripotent cells, in embryonic stem cells, and during preimplantation development. However, how chromatin assembly and the associated changes in chromatin accessibility influence TE expression and how TEs in turn impact cell fate control during lineage differentiation has not been explored. To address this problem, we propose to investigate the regulation of TEs and consequences of their reactivation by taking differentiation of the myeloid lineage as a well-defined study paradigm. Our preliminary results reveal discrete, TE-rich heterochromatic regions whose restricted chromatin accessibility is important for maintenance of the myeloid progenitor state. We propose to dissect the mechanisms sustaining the silent status of TEs and their impact on cell fate decisions by (1) defining transcriptional and epigenetic maps of TEs in normal myeloid progenitors, their normal differentiated progeny, and upon genetic perturbation of chromatin accessibility (2) assessing the function of activated TEs through genetic and biochemical approaches. Our studies will shed light on the regulation of TEs during normal cell differentiation and the impact of their misregulation in cancer.
Astyanax ajuricaba Marinho & Lima 2009
Creators: name: Langeani, Francisco
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Characiformes
Characidae
Astyanax
Astyanax ajuricaba

description: Astyanax ajuricaba Marinho & Lima (2009).
Paratypes: 1 lot, 5 specimens; DZSJRP 11286, 59.3–64.7 mm SL, rio Tapajós, Maloquinha, Itaituba, Pará, Brazil, 4°17’S, 55°59’W, cols. Expedição Permanente à Amazônia, 11–13 November 1970.
description: Published as part of Langeani, Francisco, 2017, Annotated catalog of the type specimens deposited at the fish collection of the " Universidade Estadual Paulista, Câmpus de São José do Rio Preto ", São Paulo, Brazil (DZSJRP), pp. 435-460 in Zootaxa 4319 (3) on page 437, DOI: 10.11646/zootaxa.4319.3.2, http://zenodo.org/record/890303
Dioxyna Frey 1945
Creators: name: El-Hawagry, Magdi S.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Tephritidae
Dioxyna

description: Genus DIOXYNA Frey
Dioxyna Frey, 1945: 62. Type species: Trypeta sororcula Wiedemann, 1830, original designation.
Dioxyna sororcula (Wiedemann, 1830)
Trypeta sororcula Wiedemann, 1830: 509. Unspecified type. Canary Is. (Teneriffa [= Tenerife]) (NHMW, Holotype probably lost).
Ensina vacillans Wollaston, 1858: 117. Syntypes. Portugal (Madeira: near Funchal) (BMNH).
Acinia valida Wollaston, 1858: 116. Syntypes. Portugal (Madeira: Porto Santo & "the two southern Dezertas ") (BMNH).
Leptomyza variipennis Wulp, 1897: 143. Holotype. Sri Lanka (Kandy) (MNM? or RMNH?, see Norrbom et al. 1999).
Ensina bisetosa Enderlein 1911: 455. Lectotype. Taiwan (Takao) (PAN).
Ensina bisetosa var. nigrinotum Enderlein, 1911: 456. Holotype. Taiwan (Takao) (PAN).
Paroxyna sororcula f. madeirensis Lindner, 1928: 30. Syntypes. Portugal (Madeira: nr. Funchal) (SMNS).
Paroxyna seguyi Zia, 1939: 12. Lectotype. China (Guangxi:
Yangso [= Yangshuo]) (IZAS).
Distribution. AF, AU, NT, NE, OR, PA: Widespread over Tropics and Subtropics of the world, Japan, Australia, s. Europe, Korea. Throughout new world from southern Canada to Chile; India; Hawaii (introduced). Egyptian localities. Coastal Strip: Abu Qir, Alexandria, Mariout, Salloum. Eastern Desert: Ismailiya, Wadi Um Elek. Gebel Elba:?. Fayoum:?. Lower Nile Valley and Delta: Abu Rawash, Cairo, Ezbet El-Nakhl, Helwan, Maadi, Shubra.
Host plants. Black-jack (Bidens pilosa L.). Source: Freidberg & Kugler (1989).
Dates of collection. Throughout the year.
description: Published as part of El-Hawagry, Magdi S., 2017, Catalogue of Egyptian Tephritoidea (Diptera: Schizophora: Acalyptratae), pp. 151-190 in Zootaxa 4299 (2) on pages 170-171, DOI: 10.11646/zootaxa.4299.2.1, http://zenodo.org/record/843233
Dysregulated immune signals in the developing liver promote pediatric hepatoblastoma
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Development and cancer are two sides of the same coin. Precise regulation of developmental pathways ensures normal cellular differentiation; dysregulation of these same pathways, however, supports unfettered cellular growth and malignant transformation. The immune system plays an important role in both settings by regulating homeostasis in embryonic tissues and by regulating tumor growth. The well-established association between immune dysregulation and preterm delivery, and the 1,200-times higher incidence of hepatoblastoma (HB) among premature infants compared to term newborns indicates that aberrant immune signals during liver development may promote malignant transformation of hepatoblasts. Our analysis of pediatric HB specimens identified a distinct population of tumor-associated macrophages (TAMs) that express several pro-tumorigenic genes, promote HB growth in an in vitro co-culture system, and are most notably distinguished from normal liver macrophages by their attenuated expression of the class A scavenger receptor MARCO. In contrast to the high levels of MARCO on macrophages in human and mouse fetal liver, the expression of MARCO on macrophages is suppressed during perinatal liver inflammation. These data support MARCO as a mechanism by which liver inflammation alters a developmentally conserved immune signaling pathway and promotes hepatoblast transformation. We hypothesize that loss of MARCO on macrophages establishes a tumor-permissive environment and that inflammation-mediated suppression of MARCO on macrophages promotes HB formation. We will use innovative tools to 1) determine whether MARCO deficiency creates a tumor permissive immune environment by enhancing immunosuppressive functions in the neonatal liver, and 2) determine whether suppression of MARCO signaling by perinatal inflammation promotes malignancy in a novel model of HB in immunocompetent neonatal mice. Successful completion of this proposal will establish how alterations to homeostatic immune pathways in the developing liver promote HB. This research will also provide the foundation for broader investigations focused on how immune functions in developing tissues are responsible for maintaining homeostasis and, when dysregulated, contribute to neonatal and pediatric cancers.
Flexible Robotic Evacuator for Minimally Invasive Brain Tumor Therapy
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The goal of this project is to design, fabricate, and test a flexible robotic evacuator that can be deployed by meso-scale steerable robots inside a brain tumor and controlled to evacuate tumor tissue at multiple locations towards conformal tumor evacuation. Glioblastoma multiforme (GBM) is one of the most challenging cancers to cure. Each year, nearly 12,000 new cases of GBM are diagnosed in the US, with the overall median survival being only 12 to 18 months. GBM rarely metastasizes to other organs; however, standard therapies with surgery via a craniotomy combined with adjuvant radiation and FDA-approved drugs can barely prevent the recurrence of GBM. For recurrent GBM (rGBM), although re-surgery can provide the best survival on select patients, most patients cannot afford re-surgery due to their generally poor health conditions. Thus, minimally invasive techniques arise to address this challenge. Nevertheless, existing tools are straight and rigid, and thus are not adequate to remove large and irregularly shaped tumors. Hence, there is an urgent need to develop a steerable robot that can be introduced through a small burr hole and manipulated throughout the tumor to remove the tumor in a minimally invasive manner. This project aims to develop and demonstrate a flexible robotic evacuator that can be integrated with steerable neurosurgical robots. The device will be made of flexible material so that it can be delivered through the curved channel of a steerable robot. In this project, we will: 1) design and fabricate a flexible robotic evacuator with a capability of aspiration and irrigation, 2) Integrate the evacuator with a steerable robot, and 3) evaluate the functionality of the robot system. With the success of this pilot project, we will pursue a NIH RO1 grant to improve the robot design, develop a planning and control system, and perform in vivo studies on normal and GBM pigs.
Optogenetic control of chromosome segregation
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: During cell division, chromosomes are segregated into two daughter cells by the mitotic spindle. Spindle microtubules pull on chromosomes through kinetochores, large protein complexes that link chromosomes to spindle microtubules. Chromosome segregation errors are one of the hallmarks of cancer. However, how such segregation errors and resulting aneuploidy causally relate to cancer cell proliferation or malignancy has remained largely obscure. A central challenge to understanding this relationship is the paucity of experimental tools to acutely and accurately control chromosome dynamics in dividing cells. Building on our recent advances in optogenetic control of intracellular dynamics in which we, for example, show that acute inhibition of microtubule plus end interactions can change mitotic spindle and chromosome dynamics, I propose to engineer innovative optogenetic tools to control chromosome movement and induce and analyze chromosome missegregation events with high spatial and temporal accuracy in live dividing cells. We will develop and evaluate three alternative approaches to optogenetically modulate chromosome segregation: 1. Design a photosensitive version of the Ndc80 complex, a highly conserved core component of the kinetochore-microtubule attachment machinery in eukaryotic cells; 2. Optogenetically inactivate the spindle assembly checkpoint to allow premature chromosome segregation; and 3. Develop an optogenetic chromosome trap. Once optimized, these optogenetic actuators will be stably integrated by genome editing into normal epithelial cells and cancer models expressing specific oncogenes to control chromosome dynamics globally and locally and ask under which conditions this is sufficient to generate chromosome segregation errors and aneuploid daughter cells. In the long-term, the optogenetic kinetochore toolbox generated in this pilot project will allow us to test hypotheses how aneuploidy causes malignant transformation and/or promotes cancer cell fitness and position us favorably for subsequent extramural grant applications.
Euarestella Hendel 1927
Creators: name: El-Hawagry, Magdi S.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Tephritidae
Euarestella

description: Genus EUARESTELLA Hendel
Euarestella Hendel, 1927a: 23. Type species: Trypeta megacephala Loew, 1846, by subsequent designation (Hendel 1927a: 174).
Euarestella kugleri Freidberg, 1974
Euarestella kugleri Freidberg, 1974: 56. Holotype. Israel (s. Negev, Elat) (TAU). Distribution. PA: Egypt, Israel.
Egyptian localities. Sinai: Bir Zrir, Nabaq, Sharm El-Sheikh, Tur, Wadi Firan, Wadi Hibran, Wadi Nazeb, Wadi Watir (Freidberg 1974) and near Nuweiba (Merz 1999).
Host plants. Iphiona scabra DC. ex Decne.
Dates of collection. April to September.
description: Published as part of El-Hawagry, Magdi S., 2017, Catalogue of Egyptian Tephritoidea (Diptera: Schizophora: Acalyptratae), pp. 151-190 in Zootaxa 4299 (2) on page 171, DOI: 10.11646/zootaxa.4299.2.1, http://zenodo.org/record/843233
Creagrutus varii Ribeiro, Benine & Figueiredo 2004
Creators: name: Langeani, Francisco
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Characiformes
Characidae
Creagrutus
Creagrutus varii

description: Creagrutus varii Ribeiro, Benine & Figueiredo (2004).
Paratypes: 1 lot, 8 specimens; DZSJRP 5424 (1 c&s), 16.5–32.5 mm SL, córrego da Prata, rio São Marcos, rio Paranaíba basin, Catalão, Goiás, Brazil, 17°47’26”S, 47°35’48”W, cols. E.S.R. Sá & C.A. Figueiredo, 25 April 2002.
description: Published as part of Langeani, Francisco, 2017, Annotated catalog of the type specimens deposited at the fish collection of the " Universidade Estadual Paulista, Câmpus de São José do Rio Preto ", São Paulo, Brazil (DZSJRP), pp. 435-460 in Zootaxa 4319 (3) on page 438, DOI: 10.11646/zootaxa.4319.3.2, http://zenodo.org/record/890303
Developing computational assay for oncogenic MYC/MAX dimerization and search on DNA
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The MYC transcription factor (TF) regulates cell growth and proliferation in both normal and cancer conditions. Over-expression or deregulation of MYC can lead to many types of human cancer. To function, MYC usually dimerizes with MAX, which controls a network of associated proteins to regulate transcription of thousands of target genes. Either mutation or malfunction of protein associations can contribute to cancer developments. In monomeric forms, the MYC/MAX bHLHLZ domain (DNA binding and dimerization) can be disordered so that targeting on individual protein sites is difficult. In contrast, regulating Myc-Max dimerization can be highly promising for cancer therapeutics. Previous biochemical studies indicate that the MYC and MAX monomers preferentially bind DNA and dimerize on the DNA. Our recently published work suggests that Myc-Max moves along DNA via coordinated inchworm stepping, and the dimer can also dissociate into monomers on DNA. It thus becomes feasible to develop a computational assay to characterize monomer vs dimer propensity of MYC/MAX and related proteins on the DNA from original to mutant or engineered systems. We plan to employ state-of-art modeling and structure-based simulations, at both residue (coarse-grained or CG) and atomic scales, to firstly calibrate Myc-Max dimerization or dissociation into monomers on DNA, based on published experimental results, e.g., on relative association strength of Myc-Max to Max-Max and Mad-Max. Once the dimerization strength tuned in the modeling produces consistent results with existing measurements, molecular dynamics (MD) simulations at both CG and atomic levels can be conducted iteratively revealing structural mechanisms. Via the computational assay, one can analyze dimer vs monomer dynamical equilibrium in the MYC/MAX interaction network under therapeutically relevant conditions, such as incorporating a newly discovered ligand that stabilizes Max-Max dimer, and testing the highly promising mutant Omomyc that competitively dimerizes with Myc as cancer therapeutics. The visualization capability of the assay also helps understanding Myc molecular biology, e.g. revealing how related dimeric TFs associate/dissociate and search along DNA at resolution beyond current experimental technologies can afford, in the original and modified systems, thus further support cancer therapeutics design.
Therapy of Myeloproliferative Neoplasms by JAK2V617F specific Trans-Splicing Ribozymes
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The proposed research will address Philadelphia chromosome negative Myeloproliferative Neoplasms (MPNs), which overproduce terminally differentiated cells of the myeloid lineage. They are associated with a reduced life expectancy and can progress to universally fatal leukemic blast transformation. Currently, the only treatment with curative potential is allogenic hematopoietic stem cell transplantation, which has a severe co-morbidity/mortality and the potential for relapse. About 70% of MPNs harbor the Janus kinase 2 pathogenic variant V617F (JAK2VF) in hematopoietic stem cells, considered the likely driver of the disease.
 We propose to optimize engi¬neered, catalytic RNA molecules (ribozymes) that can differentiate between JAK2VF and wild type (WT) JAK2 to specifically kill diseased cells, for a new therapeutic strategy with curative potential for JAK2VF+ MPNs. The approach uses engineered, trans-splicing variants of naturally cis-splicing group I intron ribozymes from the species Tetrahymena. These trans-splicing ribozymes can recognize a specific sequence on a target mRNA and replace the 3'-portion of the mRNA with the ribozyme's 3'-exon. If the 3'-exon encodes a cytotoxic peptide and this exon is spliced in-frame into the target mRNA then translation from the target mRNA leads to cell death due to the cytotoxin. Importantly, the V617F mutation can be recognized by the ribozyme to facilitate cell death specifically for JAK2VF+ cells.
 The proposed research activities will optimize the specificity of ribozyme trans-splicing on JAK2VF mRNA. A high specificity is essential to the proposed therapy because off-target splicing could kill healthy cells. Together with a collaborator, we have previously shown that a designed, but not optimized ribozyme can indeed splice at the intended target site. To optimize the ribozyme's specificity for JAK2VF mRNA we will generate combinatorial libraries of this ribozyme with partially randomized sequences. These libraries will be exposed to JAK2VF mRNA in a high background of competitor RNA to select for specific splicing on JAK2VF mRNA. Successful ribozyme variants will transfer a unique barcode from their 3'-exon into splice products, where they are identified by High Throughput Sequencing.
Biomonitoring a new pathway to breast cancer: Effects of steroidogenic chemicals on the metabolome
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: This study targets a novel hypothesis and a new class of endocrine disrupting chemicals (EDC) that increase estradiol (E2) and progesterone (P4) production - and then directly measures hormone levels and the blood biomarkers to detect early biological effects of EDC exposures to elucidate functional pathways linking exposure and hormone levels. While previous research has focused on chemicals that mimic estrogen, our study targets two different hormonal pathways -- chemicals that stimulate the production of natural E2 or P4. Our team identified almost 300 chemicals shown to increase production of these hormones in a cell culture assay (H295R). To connect these laboratory results to human health, we will test the hypothesis that chemicals that increase the ability of cells to produce E2 and P4 are also associated with higher levels of these hormones in women’s blood, strongly suggesting that exposures could increase breast cancer risk.
 We will use urine and serum from the Women Workers Biomonitoring Collaborative (WWBC) 2019 cohort of nurses and office workers along with existing metabolomic data to pursue the following aims:
 Aim 1: Measure associations between steroid hormone levels and exposures to EDCs that increase E2 and P4 in cells in a lab. EDC exposures include aromatic amines, bisphenols, phthalates, parabens, and UV filters, all widely used in consumer products and workplaces.
 Aim 2: Identify associations between targeted EDC exposures and early biological effects of relevance to breast cancer.
 Aim 3: Compare nurse and office worker exposures using a non-targeted screening approach. Use existing non-targeted chemical screening data to compare nurses and office workers and try to identify chemicals that are more common and higher in nurses.
 If we find that exposures to our targeted chemicals are associated with higher E2 or P4 levels in women, it would demonstrate the relevance of the H295R lab assay for human exposure and hormonal effects and support classifying chemicals that alter hormones in women as breast carcinogens; these results in turn would help accelerate screening of environmental chemicals and strengthen regulations for exposure reduction and reformulation of these compounds to avoid them.
Additional file 1: of Time series livestock diet optimization: cost-effective broiler feed substitution using the commodity price spread approach
Creators: name: Alqaisi, Othman
name: Oghaiki Ndambi
name: Williams, Ryan
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Plant Biology
subject: Computational Biology

description: Annex 1: Corn and wheat inclusion rates in broiler diets as a function of corn-wheat price spread in the CSD model. a Starter. b Grower. c Finishers. Annex 2: SBM and RSM inclusion rates in broiler diets as a function of SBM-RSM price spread in the CWSR model. a Starter. b Grower. c Finishers. Annex 3: Correlation matrix of optimized feed composition in the simulated starter diet of the CWSR model. Annex 4: Correlation matrix of optimized feed composition in the simulated grower diet of the CWSR model. Annex 5: Correlation matrix of optimized feed composition in the simulated finisher diet of the CWSR model. Annex 6: Upper and lower simulated price boundaries of feeds in the CSD LP model between 2008 and 2016. Annex 7: Upper and lower simulated price boundaries of feeds in the CWSR LP model between 2004 and 2015. Annex 8: Simulated compound feed price for starter, grower, and finisher broiler diets in the CWSR and CSD models. (DOCX 7045 kb)
Ptyas doriae
Creators: name: Meetei, Asem Bipin
name: Das, Sunandan
name: Campbell, Patrick D.
name: Raha, Sujoy
name: Bag, Probhat
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy

description: Redescription of Ptyas doriae (Boulenger, 1888)
The original description of Ptyas doriae (as Cyclophiops doriae) by Boulenger (1888) was brief and based on two specimens only. Also, a lack of knowledge of intrapopulational variation at the time probably led to the recognition of NHML 1946.1.5.32 as belonging to adifferent species by Boulenger (1900). Subsequent treatments (e.g. Pope 1935; Smith 1943) of this species were also very brief. Hence, a thorough redescription including an account of intrapopulational variation in lepidosis and colour description of this species is necessary. Here we provide a redescription based on our material (Appendix 1).
description: Published as part of Meetei, Asem Bipin, Das, Sunandan, Campbell, Patrick D., Raha, Sujoy & Bag, Probhat, 2018, A study on Ptyas doriae (Boulenger, 1888) with comments on the status of Ptyas hamptoni (Boulenger, 1900) (Squamata: Colubridae: Colubrinae), pp. 537-548 in Zootaxa 4457 (4) on page 539, DOI: 10.11646/zootaxa.4457.4.3, http://zenodo.org/record/1458015
Grundulus cochae Roman-Valencia, Paepke & Pantoja 2003
Creators: name: Langeani, Francisco
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Characiformes
Characidae
Grundulus
Grundulus cochae

description: Grundulus cochae Román-Valencia, Paepke & Pantoja (2003).
Paratypes: 1 lot, 3 specimens; DZSJRP 7498 (1 c&s), laguna de la Cocha, vereda Romerillo, Nariño, Pasto, Colombia, el. 2809 m, 1°05’22”N, 77°09’50”W, col. C. Román-Valencia, 15 August 2000.
description: Published as part of Langeani, Francisco, 2017, Annotated catalog of the type specimens deposited at the fish collection of the " Universidade Estadual Paulista, Câmpus de São José do Rio Preto ", São Paulo, Brazil (DZSJRP), pp. 435-460 in Zootaxa 4319 (3) on page 438, DOI: 10.11646/zootaxa.4319.3.2, http://zenodo.org/record/890303
Epicutaneous immunotherapy for the treatment of peanut allergy in children and young adults
Creators: name: Lindblad, Robert W.
name: Consortium of Food Allergy Research
name: Sicherer, Scott H.
name: Pesek, Robbie D.
name: Dawson, Peter
name: Sampson, Hugh A.
name: Wood, Robert A.
name: Cho, Christine B.
name: Berin, M. Cecilia
name: Henning, Alice K.
name: Burks, A. Wesley
name: Chiang, David
name: Plaut, Marshall
name: Leung, Donald Y.M.
name: Davidson, Wendy F.
name: Jones, Stacie M.
name: Vickery, Brian P.
Publisher: name: Elsevier
Year: 2016

description:
BACKGROUND: Peanut allergy is common, life-threatening, and without therapeutic options. We evaluated peanut epicutaneous immunotherapy (EPIT) by using Viaskin Peanut for peanut allergy treatment. OBJECTIVE: We sought to evaluate the clinical, safety, and immunologic effects of EPIT for the treatment of peanut allergy. METHODS: In this multicenter, double-blind, randomized, placebo-controlled study, 74 participants with peanut allergy (ages 4-25 years) were treated with placebo (n = 25), Viaskin Peanut 100 μg (VP100; n = 24) or Viaskin Peanut 250 μg (VP250; n = 25; DBV Technologies, Montrouge, France). The primary outcome was treatment success after 52 weeks, which was defined as passing a 5044-mg protein oral food challenge or achieving a 10-fold or greater increase in successfully consumed dose from baseline to week 52. Adverse reactions and mechanistic changes were assessed. RESULTS: At week 52, treatment success was achieved in 3 (12%) placebo-treated participants, 11 (46%) VP100 participants, and 12 (48%) VP250 participants (P = .005 and P = .003, respectively, compared with placebo; VP100 vs VP250, P = .48). Median change in successfully consumed doses were 0, 43, and 130 mg of protein in the placebo, VP100, and VP250 groups, respectively (placebo vs VP100, P = .014; placebo vs VP250, P = .003). Treatment success was higher among younger children (P = .03; age, 4-11 vs >11 years). Overall, 14.4% of placebo doses and 79.8% of VP100 and VP250 doses resulted in reactions, predominantly local patch-site and mild reactions (P = .003). Increases in peanut-specific IgG4 levels and IgG4/IgE ratios were observed in peanut EPIT-treated participants, along with trends toward reduced basophil activation and peanut-specific TH2 cytokines. CONCLUSIONS: Peanut EPIT administration was safe and associated with a modest treatment response after 52 weeks, with the highest responses among younger children. This, when coupled with a high adherence and retention rate and significant changes in immune pathways, supports further investigation of this novel therapy.
Euarestella iphionae
Creators: name: El-Hawagry, Magdi S.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Tephritidae
Euarestella
Euarestella iphionae

description: Euarestella iphionae (Efflatoun, 1924)
Euaresta iphionae Efflatoun, 1924b: 152. Holotype. Egypt (Wadis Hussein, Hoff, Rishrash, Digla & Garawy) (ESEC). Euarestella iphioniae Foote, 1984: 87. Misspelling, attributed to "author".
Distribution. AF: Sudan. PA: Egypt, Iran, Israel, Saudi Arabia.
Egyptian localities. Eastern Desert: Gebel Asfar, Suez Road, Wadi Abu Nossour, Wadi Digla, Wadi Garawy, Wadi Gharagid, Wadi Hoff, Wadi Hussein, Wadi Rishrash, Wadi Um Elek, Wadi Zohleiga. Lower Nile Valley and Delta: Ezbet El-Nakhl, Faraskour, Giza, Qubba, Shoubra. Sinai: Wadi Gedeirat.
Host plants. Iphiona mucronata (Forssk.) Asch. & Schweinf.
Dates of collection. Throughout the year.
description: Published as part of El-Hawagry, Magdi S., 2017, Catalogue of Egyptian Tephritoidea (Diptera: Schizophora: Acalyptratae), pp. 151-190 in Zootaxa 4299 (2) on page 171, DOI: 10.11646/zootaxa.4299.2.1, http://zenodo.org/record/843233
Influence of growth hormones and mechanical loading on osteosarcoma progression
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Osteosarcoma (OS) is the most common primary malignant tumor of bone in children and young adults. Adjuvant chemotherapy and surgical resection has been used to treat OS for decades, with 5-year survival rates of 60-70%. Unfortunately, for those patients with metastatic disease, 5-year survival rates are dismal (less than 30%), motivating the urgent need to understand what triggers the migration of OS cells from the bone into surrounding tissue, and eventually distant metastasis to the lungs.

 When studied in monolayer culture, cancer cells are deprived of their native microenvironment and lose the tumor phenotype, making their responsiveness to therapy inaccurate. Animal models, considered essential for cancer research, also fail to accurately predict clinical outcomes. Tumor features have been created in biomaterials to model both the structural and cellular composition of the bone and marrow microenvironments. Mechanical stimuli also play a key role in tissue development and diseases such as cancer. For instance, OS thrives in a mechanically active microenvironment, especially during the teenage growth spurt. This suggests there may be a link between mechanical signaling, bone growth, and tumor formation that merits further study.

 We hypothesize that OS progression and metastatic potential will be increased with exposure to pubescent growth hormones and mechanical loading. Murine OS cell lines or MC3T3 pre-osteoblasts will be entrapped in engineered constructs mimicking the composition and structure of bone marrow. Constructs will undergo dynamic compressive loading in a bioreactor for 2 h per day for 7 days in complete media or media supplemented with testosterone, β-Estradiol, or dihydrotestosterone. We will measure changes in bone formation and known metastatic signaling pathways by standard biochemical assays (e.g., PCR, RNAseq, IHC), while metastatic potential will be examined by tracking metastasis to the lungs upon murine subcutaneous implantation. We will also test efficacy of known chemotherapeutic drugs (i.e., doxorubicin) on stimulated constructs both in vitro and in vivo. The results will reveal the synergy of mechanical signaling on tumor growth in the presence of growth hormones and establish the importance of mechanical loading as potential drug targets to slow the growth and metastasis of OS.
Hasemania kalunga Bertaco & Carvalho 2010
Creators: name: Langeani, Francisco
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Characiformes
Characidae
Hasemania
Hasemania kalunga

description: Hasemania kalunga Bertaco & Carvalho (2010).
Paratypes: 1 lot, 12 specimens; DZSJRP 12339 (1 c&s), 19.8–38.6 mm SL, córrego in the road GO 241 between Cavalcante and Minaçu, tributary to rio das Almas, rio Paranã drainage, upper rio Tocantins basin, Cavalcante, Goiás, Brazil, el. 1163 m, 13°36’56.7”S, 47°31’06.6”W, cols. V.A. Bertaco, F.R. Carvalho & G. Frainer, 7 September 2009.
description: Published as part of Langeani, Francisco, 2017, Annotated catalog of the type specimens deposited at the fish collection of the " Universidade Estadual Paulista, Câmpus de São José do Rio Preto ", São Paulo, Brazil (DZSJRP), pp. 435-460 in Zootaxa 4319 (3) on page 438, DOI: 10.11646/zootaxa.4319.3.2, http://zenodo.org/record/890303
СПОСОБЫ УСИЛЕНИЯ СТАБИЛЬНОСТИ ФУНКЦИОНИРОВАНИЯ ЭКОНОМИЧЕСКОЙ СИСТЕМЫ
Creators: name: Саминжонов, Нуриллохон
Publisher: name: Zenodo
Year: 2025

description: Данная статья посвящена анализу ключевых мер, направленных на повышение стабильности функционирования экономической системы как в разрезе отдельных объектов, так и в комплексе. Мы рассмотрим различные инструменты, применяемые для повышения устойчивости и адаптивности к внешним и внутренним шокам, а также проанализируем их эффекты в контексте различных секторов экономики.
Hasemania piatan Zanata & Serra 2010
Creators: name: Langeani, Francisco
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Characiformes
Characidae
Hasemania
Hasemania piatan

description: Hasemania piatan Zanata & Serra (2010).
Paratypes: 1 lot, 20 specimens; DZSJRP 11933 (3 c&s), 23.1–33.5 mm SL, córrego das Piabas, south of Fazenda Piabas, tributary of rio de Contas, Piatã, Bahia, Brazil, el. 1336 m, 13°8’49”S, 41°50’33”W, cols. A. M. Zanata, P. Camelier & A. G. A. Borges, 13 September 2007.
description: Published as part of Langeani, Francisco, 2017, Annotated catalog of the type specimens deposited at the fish collection of the " Universidade Estadual Paulista, Câmpus de São José do Rio Preto ", São Paulo, Brazil (DZSJRP), pp. 435-460 in Zootaxa 4319 (3) on page 439, DOI: 10.11646/zootaxa.4319.3.2, http://zenodo.org/record/890303
LMS (LEARNING MANAGAMENT SYSTEM)-TAʻLIMNI BOSHQARUV TIZIMLARI
Creators: name: Qarshiyeva, Eʻzoza
name: Nurullayeva, Malika
name: Yaxiyaxonova, Muxiba
Publisher: name: Zenodo
Year: 2025

description: LMS (Learning Management System) — taʻlimni boshqarish tizimlari bugungi kunda taʻlim jarayonlarini soddalashtirish va optimallashtirishda muhim vosita sifatida xizmat qilmoqda. Ushbu annotatsiyada LMSlarning asosiy tushunchalari, funktsiyalari va taʻlim sohasidagi ahamiyati batafsil koʻrib chiqiladi. LMS - bu onlayn platforma boʻlib, oʻqituvchilar va oʻquvchilar oʻrtasidagi aloqani kuchaytirish, oʻquv materiallarini taqdim etish va baholash jarayonlarini boshqarish imkonini beradi. Taʻlim muassasalari va korporativ taʻlimda keng qoʻllanilayotgan ushbu tizimlar, oʻquvchilarga qulay sharoit yaratish, ularning bilim va koʻnikmalarini baholashda samarali vositalarni taklif etadi. LMSʻlarning asosiy funktsiyalari orasida kurslarni yaratish va boshqarish, oʻquvchilarni roʻyxatdan oʻtkazish, materiallarni yuklash, test va topshiriqlarni tayyorlash hamda baholash jarayonini avtomatlashtirish kabilar mavjud.
Euarestella pninae Freidberg 1981
Creators: name: El-Hawagry, Magdi S.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Tephritidae
Euarestella
Euarestella pninae

description: Euarestella pninae Freidberg, 1981
Euarestella pninae Freidberg, 1981: 25. Holotype. Israel (Ein Feschkha) (TAU). Distribution. PA: Egypt, Israel.
Egyptian localities. Sinai: near Nuweiba, Sinai Mts.
Host plants. Crisp-leaved fleabane (Pulicaria desertorum (DC.)). Source: Freidberg & Kugler (1989). Dates of collection. April.
description: Published as part of El-Hawagry, Magdi S., 2017, Catalogue of Egyptian Tephritoidea (Diptera: Schizophora: Acalyptratae), pp. 151-190 in Zootaxa 4299 (2) on page 171, DOI: 10.11646/zootaxa.4299.2.1, http://zenodo.org/record/843233
WUI Research for Resilience: Addressing California’s Climate, Conservation, and Housing Crises
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Housing development in the Wildland Urban Interface [WUI] is the fastest growing land use in California, and a leading cause of wildfire, natural area loss, and climate change. Yet there is no systematic research on who is moving there and why, or their related socio-environmental impacts and vulnerabilities, and thus how to integrate WUI growth in climate resiliency planning. Led by experts in the social and natural sciences, emergency management and land stewardship, this project will offer new ecological and equity related approaches to resiliency policy and planning. Centered on the Central Coast, findings will apply to regions across California and beyond.

 We develop a novel framework to analyze the "3 Ds": drivers, demographics, and dynamics of WUI growth. Combining census and GIS analysis with a survey and interview-based “affordability-desirability nexus” study, we explore push-pull factors of WUI migration, including housing cost pressures in proximal urban areas alongside lifestyle motivations. We then explore associated dynamics for affordability migrants in terms of social vulnerability, hazardous land use, and widening commute sheds. We combine select 3D variables with ecological and biophysical variables to develop distinct and significant "WUI typologies." These will be applied to map-based case studies of fire risk and habitat fragmentation in our region using ecological surveys, integrated step selection analysis, ethnography, and stakeholder interviews. Finally we combine the 3 D’s, typologies, and case study data in a novel, scalable, user-friendly web-based tool, the "WUI Equity Atlas." Integrating land use, ecological, and equity-oriented research, the Atlas informs regional planning decisions that weigh the costs, benefits, and tradeoffs of different locations for housing, conservation, and mitigation. We will also use the Atlas in regional stakeholder gatherings, including indigenous tribes, public lands, labor, agriculture, housing, and social and emergency services. Working together we will inform approaches to equitable resiliency planning at the nexus of California’s housing, conservation, and climate crises. This will advance state goals to “prioritize which indicators to include” in addressing climate change, as well as to “identify quantifiable measures to assess and identify vulnerable communities."
A fusion outlook product for predicting climate-water variation toward efficient decision making
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Unprecedented changes in climate and increasingly frequent anomalous events affect water security, agricultural (Ag) production, and local economy and communities. The occurrences and impacts of these changes are difficult to predict, impairing our ability to build resilience into the water management and Ag systems.

 Predictability of hydroclimate variability relies on climate models with simplified assumptions. Forecasts for the state of California (CA) based on NOAA’s National Multi-Model Ensemble (NMME) forecasts are not directly constrained by real-time observations and show limited skills in predicting sub-seasonal to seasonal (S2S) hydroclimate changes in CA.

 Here, we use expertise in Earth Science, remote sensing, and AI modeling to develop a novel fusion outlook product that combines NMME forecasts, in-situ and satellite-based observations for predicting S2S variations of CA hydroclimate. We devise AI techniques to fuse model-based forecasts with NASA satellite observations of changes in precipitation, terrestrial water storage, and soil moisture to enhance forecast capability. The fusion approach employs existing field datasets from CA resources and remote sensing observations to identify and correct dynamic biases in the NMME solutions. The forward-looking deliverables and uncertainties will be updated and distributed in real time. The product development and evaluation will be done in collaboration with UC-Agriculture and Natural Resources extension specialists, partners at the California Department of Water Resources, farmers, and companies who already work with stakeholders. Within this collaborative framework, we will quantify and demonstrate product skills, design, refine product interface, deploy for early adoption, and collect end users’ feedback.

 The framework constituted by our multidisciplinary team will facilitate the usage of climate science to help decision making in water and Ag management. Our S2S outlook products with enhanced forecast capacity will be incorporated into CA climate toolbox for adoption in water allocation workflows and shared with industrial partners. This work will yield quantifiable savings in water resources and energy due to improved water management efficiency. It will serve CA’s overarching climate action research priorities in Climate Adaptation Strategy, Climate dashboard, and Climate solutions.
Goniurellia Hendel 1927
Creators: name: El-Hawagry, Magdi S.
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Tephritidae
Goniurellia

description: Genus GONIURELLIA Hendel
Trypanea (Goniurellia) Hendel, 1927a: 23. Type species: Urellia tridens Hendel, 1910, by subsequent designation of I.C.Z.N. (1982: 109).
description: Published as part of El-Hawagry, Magdi S., 2017, Catalogue of Egyptian Tephritoidea (Diptera: Schizophora: Acalyptratae), pp. 151-190 in Zootaxa 4299 (2) on page 171, DOI: 10.11646/zootaxa.4299.2.1, http://zenodo.org/record/843233