cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
IN SEARCH OF A SMALL MOLECULE CURE FOR HIV-AIDS: DEVELOPMENT OF DUAL-ACTION AGENTS CAPABLE OF SIMULTANEOUSLY ACTIVATING HIV-1 LATENCY AND PREVENTING NEW INFECTION
Creators: name: kumar, Abhijith Anil
Publisher: name: Purdue University Graduate School
Year: 2025
Subjects: classificationCode: 340503
subject: Organic chemical synthesis
classificationCode: 340499
subject: Medicinal and biomolecular chemistry not elsewhere classified

description: We hypothesized that by activating latent HIV-1 cells out of latency and simultaneously preventing new infections by the same drug we would be able to potentially find a cure for HIV-AIDS. Dual-action drugs targeting HIV latency and preventing new infections is a novel approach that has not been explored previously. We have identified HDAC as the target for latency and HIV-1 protease (HIV-1 PR) as the target for preventing new infections. Macrocyclic inhibitors of HDAC and HIV PR were identified from literature, synthesized and subsequently studied in detail. New dual inhibitors were designed after extensive NMR and computational studies. The HDAC inhibitors, however, did not show the expected activity against HDAC 3. The macrocycles were modified by changing the linker, zinc-binding group (ZBG) and the stereochemistry and tested for inhibition of HIV-1 PR and HDAC 3. These modified compounds continued to show poor HDAC 3 inhibition. A different approach was taken by using amprenavir and incorporating different linkers and ZBG to develop dual inhibitors. We developed the first dual inhibitors of HDAC 3, and HIV PR showing low micromolar inhibition. The best inhibitor was tested in cells and demonstrated the ability to activate latently infected ACH-2 cells out of latency in a concentration dependent manner. Unfortunately, the molecule could not prevent new infections in any noticeable manner. We reasoned that with better HIV PR inhibition we would be able to achieve both of our goals. The first two new inhibitors synthesized were poor HDAC 3 inhibitors and we are currently in the process of developing new inhibitors.
Проблемы реализации целей устойчивого развития в России
Creators: name: Смирнова Тамара Сергеевна
name: Камышников Иван Николаевич
Publisher: name: Московский экономический журнал
Year: 2019
Subjects: ЦУР
ООН
ПРОГРАММНЫЕ ДОКУМЕНТЫ
РЕАЛИЗАЦИЯ ЦЕЛЕЙ УСТОЙЧИВОГО РАЗВИТИЯ
СБОР ИНДИКАТОРОВ ЦУР
СИСТЕМА УПРАВЛЕНИЯ УСТОЙЧИВЫМ РАЗВИТИЕМ В РОССИИ
SDG
UN
PROGRAM DOCUMENTS
IMPLEMENTATION OF SUSTAINABLE DEVELOPMENT GOALS
COLLECTION OF SDG INDICATORS
SUSTAINABLE DEVELOPMENT MANAGEMENT SYSTEM IN RUSSIA

description: В статье рассматриваются основные программные документы по реализации целей устойчивого развития, отмечаются основные проблемы реализации целей устойчивого развития в России, в том числе, что не всем целям устойчивого развития (ЦУР) уделяется должное внимание. Подчеркивается выступление Росстата с инициативой закрепления за ним обязанностей по организации и сбора индикаторов ЦУР и необходимость создания полноценной системы управления устойчивым развитием в России, которая будет включать в себя участие всех заинтересованных сторон, и использовать критерии, соответствующие критериям реализации ЦУР.The article discusses the main policy documents on the implementation of sustainable development goals, highlights the main problems of achieving the goals of sustainable development in Russia, including that not all the goals of sustainable development (SDGs) receive enough attention. The performance of Rosstat is underlined with the initiative of entrusting it with responsibilities for organizing and collecting SDG indicators and the need of creating a full-fledged system for managing sustainable development in Russia, which will include the participation of all stakeholders, and use criteria that meet the criteria for implementing the SDGs.
РЕГИОНАЛЬНАЯ ПОЛИТИКА РАЗВИТИЯ МАЛОГО И СРЕДНЕГО БИЗНЕСА В КЫРГЫЗСКОЙ РЕСПУБЛИКЕ В УСЛОВИЯХ КРИЗИСА
Creators: name: П.К. Алишева
Publisher: name: Экономика и бизнес: теория и практика
Year: 2021
Subjects: малый и средний бизнес
бизнес-среда
регионы
рынок
государственная поддержка
льготы
конкурентная среда
рабочие места
региональный потенциал
фонд развития
стратегическая программа

description: В статье исследованы проблемы, с которыми сталкиваются предприятия в условиях кризиса, меры по оказанию государственной поддержки малому и среднему бизнесу. По результатам проведенного анализа предложены рекомендации по поддержке малого и среднего бизнеса в Кыргызской Республике
Некоторые аспекты типологии лидерства в условиях управления изменениями
Creators: name: Егоров Евгений Евгеньевич
name: Виноградова Светлана Александровна
name: Лазутин Виктор Романович
Publisher: name: Московский экономический журнал
Year: 2019
Subjects: СОВРЕМЕННЫЙ МЕНЕДЖМЕНТ
ЛИДЕРСТВО
ТИПОЛОГИИ ЛИДЕРСТВА
ТРАНЗАКЦИОННОЕ И ТРАНСФОРМАЦИОННОЕ ЛИДЕРСТВО
УПРАВЛЕНИЕ ИЗМЕНЕНИЯМИ
MODERN MANAGEMENT
LEADERSHIP
LEADERSHIP TYPOLOGIES
TRANSACTIONAL AND TRANSFORMATIONAL LEADERSHIP
CHANGE MANAGEMENT

description: В статье изложены некоторые аспекты применения типологии лидерства. Целью данной статьи является выявление наиболее актуальных типов лидерства и определение наиболее востребованных компетенций руководителей современных организаций. Типология лидерства рассматривается с точки зрения управления изменениями в современном мире. Приводится сравнение двух типологий лидерства. Рассматриваются традиционные и современные типологии лидерства. Основное внимание уделяется сравнению транзакционного и трансформационного стиля лидерства в управлении организацией. Также рассматриваются основные качества, которые должны быть присущи современному лидеру в эпоху неопределенности, сложности и динамичности окружающей среды.The article outlines some aspects of the use of leadership typology. The purpose of this article is to identify the most relevant types of leadership and identify the most sought-after competencies of managers of modern organizations. The typology of leadership is viewed from the perspective of change management in the modern world. A comparison of two typologies of leadership is given. We consider the traditional and modern typologies of leadership. The focus is on comparing the transactional and transformational leadership styles in managing an organization. It also discusses the main qualities that should be inherent in the modern leader in an era of uncertainty, complexity and dynamic environment.
Υπερκυκλικά διανύσματα φραγμένων τελεστών
Creators: name: Παπαθανασίου, Δημήτρης Αργυρίου
Publisher: name: Aristotle University of Thessaloniki
Year: 2013
Subjects: κοινά υπερκυκλικά διάνυσματα
υπερκυκλικός τελεστής
καθολική οικογένεια
common hypercyclic vectors
hypercyclic operator
universal family

description: Η παρούσα διπλωματική εργασία αφορά στη μελέτη της ύπαρξης κοινών υπερκυκλικών διανυσμάτων υπεραριθμήσιμων οικογενειών τελεστών. Αρχικά, περιγράφονται συνοπτικά οι έννοιες των υπερκυκλικών τελεστών και των αντίστοιχων υπερκυκλικών διανυσμάτων τους, καθώς επίσης και τα βασικά αποτελέσματα που σχετίζονται με αυτές. Στη συνέχεια, αποδεικνύονται κάποιες γενικές συνθήκες για την ύπαρξη κοινών υπερκυκλικών διανυσμάτων. Με χρήση των συνθηκών αυτών αποδεικνύεται η ύπαρξη κοινών υπερκυκλικών διανυσμάτων μερικών συγκεκριμένων οικογενειών τελεστών όπως είναι οι τελεστές μετατόπισης, στον χώρο των ακεραίων συναρτήσεων, οι συζηγείς πολλαπλασιαστικοί τελεστές, στον χώρο Hardy και οι τελεστές που μετατίθενται με τον τελεστή διαφόρισης. Τέλος, αποδεικνύεται μια αναγκαία συνθήκη για την ύπαρξη κοινών υπερκυκλικών διανυσμάτων μιας τριπαραμετρικής οικογένειας τελεστών και σαν πορίσματα αυτής, παρατίθενται κάποιες οικογένειες τελεστών που δεν έχουν κοινά υπερκυκλικά διανύσματα.
description: The main subject of this master thesis is the existence of common hypercyclic vectors for uncountable families of hypercyclic operators. Firstly, we describe the notions of a hypercyclic operator and its correspondent hypercyclic vectors as well as the fundamental results related to them. Additionally, we prove some general conditions concerning the existence of common hypercyclic vectors. Using these conditions, we prove the existence of common hyprcyclic vectors for some specific families of operators like the translation operators acting on the space of entire functions, the adjoint multiplication operators acting on the Hardy space and operators commuting with the differentiation operator. Finally, we prove a necessary condition for the existence of common hypercyclic vectors for a three-parametric family of operators. As a corollary we present some families of operators that do not share any hypercyclic vector.
Numerical Analysis of the Anderson Localization
Creators: name: Markos, Peter
Publisher: name: arXiv
Year: 2006
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The aim of this paper is to demonstrate, by simple numerical simulations, the main transport properties of disordered electron systems.
description: submitted to acta physica slovaca
ОСОБЕННОСТИ ПРИМЕНЕНИЯ МАРКЕТИНГОВЫХ ИНСТРУМЕНТОВ В ПРОДВИЖЕНИИ УСЛУГ
Creators: name: В.К. Романович
name: П.В. Андрюк
Publisher: name: Экономика и бизнес: теория и практика
Year: 2021
Subjects: продвижение
услуга
сфера услуг
маркетинговые инструменты
реклама
стимулирование сбыта
личная продажа
социальные сети
паблик рилейшнз

description: В статье рассмотрены особенности маркетингового инструментария, применяемого при продвижении услуг на рынке. Выявлены основные отличия услуг от товаров и определены наиболее эффективные методы их продвижения. Подробно изучены и предложены дополнительные методы продвижения услуг на рынке с учетом современных требований потребителей. Также рассмотрены новые методы продвижения услуг на основе использования современной техники и технологий
Εφαρμογή τεχνολογιών και υπηρεσιών σημασιολογικού ιστού στην αυτοματοποίηση της βιομηχανικής παραγωγής
Creators: name: Χατζής, Σπυρίδων Αλκιβιάδη
Publisher: name: Aristotle University of Thessaloniki
Year: 2013
Subjects: Ιστός
Υπηρεσίες
Σημασιολογία
Web
Services
Semantics

description: Σκοπός της εργασίας ήταν η διερεύνηση της εφαρμογής τεχνολογιών και υπηρεσιών σημασιολογικού ιστού στην αυτοματοποίηση της βιομηχανικής παραγωγής. Παρουσιάστηκε μία ανασκόπηση ορισμένων προτάσεων και χαρακτηριστικών υλοποιήσεων τέτοιων εφαρμογών από τη διεθνή βιβλιογραφία. Στη συνέχεια σχεδιάστηκε και αναπτύχθηκε μία εφαρμογή επιτήρησης και συλλογής δεδομένων σε γραμμή συσκευασίας προϊόντων. Η σχεδίαση της εφαρμογής βασίστηκε στην αρχιτεκτονική των υπηρεσιών και για την επικοινωνία των μηχανών υιοθετήθηκαν τα πρωτοκόλλα και τα πρότυπα του παγκόσμιου ιστού. Ταυτόχρονα, ο εξοπλισμός της γραμμής συσκευασίας μοντελοποιήθηκε συνοπτικά με μία οντολογία εξοπλισμού και οι υπηρεσίες περιγράφησαν με οντολογία ως υπηρεσίες σημασιολογικού ιστού. Τέλος, η εφαρμογή υλοποιήθηκε ως προσομοίωση σε υπολογιστή με εγκατάσταση των προτεινόμενων υπηρεσιών και αξιοποίησή τους από εφαρμογή - πελάτη.
description: The aim of the present thesis was to investigate the application of technologies and services of the semantic web in automation of industrial production. An overview of some proposals and notable implementations of such applications was presented by the international literature. Then, a monitoring and data collection application was designed and developed for a packaging production line. The application design was based on the architecture of services, and for the communication of the machines the protocols and standards of the web were adopted. At the same time, the packaging line equipment was briefly modeled with an equipment ontology and the services were described with a service ontology as semantic web services. Finally, the application was implemented as a computer simulation with the deployment of the proposed services and their use by a client application.
description: Σε συνεργασία με το τμήμα Λογιστικής και Χρηματοοικονομικής (Πανεπιστήμιο Μακεδονίας)
Wilson-like real-space renormalization group and low-energy effective spectrum of the XXZ chain in the critical regime
Creators: name: Okunishi, Kouichi
Publisher: name: arXiv
Year: 2007
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We present a novel real-space renormalization group(RG) for the one-dimensional XXZ model in the critical regime, reconsidering the role of the cut-off parameter in Wilson's RG for the Kondo impurity problem. We then demonstrate the RG calculation for the XXZ chain with the free boundary. Comparing the hierarchical structure of the obtained low-energy spectrum with the Bethe ansatz result, we find that the proper scaling dimension is reproduced as a fixed point of the RG transformation.
description: 4 pages, 6 figures, typos corrected, final version
Состояние электронной торговли России и перспективы ее развития в Забайкальском крае
Creators: name: Лиценберг Ирина Ивановна
Publisher: name: Московский экономический журнал
Year: 2019
Subjects: ЦИФРОВАЯ ЭКОНОМИКА
ЭЛЕКТРОННАЯ ТОРГОВЛЯ
ИНТЕРНЕТ-МАГАЗИН
B-2-B-МАРКЕТПЛЕЙС
DIGITAL ECONOMY
E-COMMERCE
ONLINE STORE
B-2-B-MARKETPLACE

description: Около 50% цифровой экономики РФ в 2018 г. составила электронная торговля [25]. Однако, в регионах она развита слабо. Целью данного исследования является анализ состояния электронной торговли РФ и выявление перспектив ее развития в Забайкальском крае. Автором статьи использованы общенаучные методы: анализ, синтез, систематизация, формализация. На основе статистических данных Федеральной службы государственной статистики, Российской ассоциации электронных коммуникаций, Ассоциации компаний интернет-торговли, результатов исследований консалтинговых компаний A.T. Kearney и Nielsen и других количественных сведений проведен анализ состояния и динамики электронной торговли. С целью определения количества онлайн-магазинов, осуществляющих дистанционную торговлю товарами с территории Забайкальского края, проведено разведочное исследование путем мониторинга информации в поисковых системах Интернет. Основное внимание уделено ключевым характеристикам отечественного рынка интернет-торговли по секторам B-2-G, B-2-B, B-2-C, C-2-C. Предложены актуальные направления развития электронной торговли в Забайкальском крае для организации сбыта продукции региональных товаропроизводителей на внутреннем и внешнем рынках.A significant share of the digital economy of the Russian Federation is e-commerce (50% by the end of 2018) [25]. However, in the regions it is underdeveloped. The purpose of this study is to analyze the state of electronic commerce in the Russian Federation and to identify the prospects for its development in the Trans-Baikal Territory. The author of the article used general scientific methods: analysis, synthesis, systematization, formalization. Based on statistical data of the Federal State Statistics Service, the Russian Association of Electronic Communications, the Association of E-commerce Companies, the results of research by consulting companies A.T. Kearney and Nielsen and other quantitative information carried out an analysis of the state and dynamics of electronic commerce. In order to determine the number of online stores engaged in distant trade in goods from the territory of the Trans-Baikal Territory, an exploratory study was conducted by monitoring information in Internet search engines. The main attention is paid to the key characteristics of the domestic e-commerce market by sectors B-2-G, B-2-B, B-2-C, C-2-C. The current directions for the development of e-commerce in the Trans-Baikal Territory for the organization of sales of products of regional producers in the domestic and foreign markets are proposed.
Basal forebrain cholinergic neurons: regulation by dopamine and responses to arousing stimuli
Creators: name: Day, Jamie Catherine
Publisher: name: University of British Columbia
Year: 2009

description: The regulation of forebrain cholinergic systems, specifically those neurons in the cholinergic basal nuclear complex (CBC) which project to the hippocampus and cortex are of great interest, given the involvement of acetyicholine (ACh) in cognitive function. To assess the activity of CBC neurons, in vivo microdialysis has been used in the present experiments to measure ACh release in the hippocampus and cortex of freely moving rats. Dialysate concentrations of ACh in the hippocampus and cortex (and striatum) of freely moving rats were found to correlate positively and significantly with locomotor activity, a behavioural measure of arousal. Two arousing stimuli, injection of vehicle and onset of the rats’ dark phase, increased locomotor activity and ACh release in all three brain regions, as did injection of the muscarinic antagonist scopolamine. These data suggest that forebrain cholinergic neurons are responsive to arousing stimuli and that ACh release in the crtex, hippocampus and striatum generally correlates with arousal. The dopaminergic regulation of CBC neurons was examined by determining the extent to which dopamine (DA) receptor agonists and antagonists affect cortical and hippocampal ACh release. The indirect DA agonist d-amphetamine (AMPH) and the DA receptor agonist apomorphine increased ACh release in both the cortex and hippocampus as did the selective D1 receptor agonist CY 208-243. D2 receptor agonists (quinpirole and/or PHNO) had no effect on ACh release in the cortex and produced slight decreases in the hippocampus. In addition, the AMPH-induced increases in ACh release in both regions were attenuated more by the D1 receptor antagonist SCH 23390 than by the D2 antagonists haloperidol and/or raclopride, as was the apomorphine induced release of ACh in the cortex. That DA mediates AMPH-induced increases in cortical ACh release was supported by the finding that prior selective lesions of ascending dopaminergic but not noradrenergic systems attenuated this effect of AMPH. These results suggest that CBC neurons are regulated in an excitatory manner by DA acting primarily at D1 receptors. The extent to which ACh release in the cortex and hippocampus is related to the performance of a learned behavioural task was assessed in rats trained to anticipate and consume a palatable liquid diet. Hippocampal ACh release increased during the anticipatory and consummatory periods of the task, but the increase observed in rats trained with the liquid diet was not higher than the increases seen in rats trained with water or in naive rats. In contrast, cortical ACh release increased to a greater extent in rewarded rats than it did in the two control groups. This suggests that cholinergic activity in both the cortex and hippocampus is increased by a reward-independent aspect of the task, such as arousal or attention, while an additional reward-dependent component is seen with respect to cortical ACh release.
ПРОБЛЕМЫ И ПРАКТИКА ИСПОЛЬЗОВАНИЯ ЭЛЕКТРОННОЙ ЦИФРОВОЙ ПОДПИСИ
Creators: name: В.Е. Наружный
name: В.В. Макаров
name: А.А. Асеев
Publisher: name: Экономика и бизнес: теория и практика
Year: 2021
Subjects: электронная цифровая подпись
механизмы защиты документации
информатизация
электронный документооборот
конфиденциальность

description: Анализируется практика использования электронной цифровой подписи (ЭЦП), необходимой для реализации системы электронного документооборота и обладающей механизмами защиты передаваемой документации. Показываются возможности и ограничения использования простой и квалифицированной ЭЦП. Исследуются преимущества и недостатки применения электронной цифровой подписи, а также причины низкого уровня ее распространенности в РФ.
Meeting the global thirst for bioinformatics training
Creators: name: Attwood, Teresa
name: Brazas, Michelle
name: Lewitter, Fran
name: Schneider, Vicky
name: GOBLET Consortium
Publisher: name: F1000Research
Year: 2015

description: Around the world, the demand for bioinformatics training is increasing, year-on-year. To meet this demand, GOBLET – the Global Organisation for Bioinformatics Learning, Education & Training – has engaged in numerous training programs and initiatives. This poster presents some of GOBLET's recent world-wide enterprises, sharing lessons learned along the way, and discussing the impact they have had on further outreach efforts.
Collective Field Formulation of the Multispecies Calogero Model and its Duality Symmetries
Creators: name: Bardek, V.
name: Feinberg, J.
name: Meljanac, S.
Publisher: name: arXiv
Year: 2006
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We study the collective field formulation of a restricted form of the multispecies Calogero model, in which the three-body interactions are set to zero. We show that the resulting collective field theory is invariant under certain duality transformations, which interchange, among other things, particles and antiparticles, and thus generalize the well-known strong-weak coupling duality symmetry of the ordinary Calogero model. We identify all these dualities, which form an Abelian group, and study their consequences. We also study the ground state and small fluctuations around it in detail, starting with the two-species model, and then generalizing to an arbitrary number of species.
description: latex, 53 pages, no figures;v2-minor changes (a paragraph added following eq. (61))
МООС в цифровом маркетинге образовательных продуктов
Creators: name: Заворина Елена Георгиевна
Publisher: name: Московский экономический журнал
Year: 2019
Subjects: ЦИФРОВОЙ МАРКЕТИНГ
ВЫСШЕЕ ОБРАЗОВАНИЕ
ОНЛАЙН-КУРСЫ
МООК
МАРКЕТИНГ-МИКС
DIGITAL MARKETING
HIGHER EDUCATION
ONLINE COURSES
MOOC
MARKETING-MIX

description: Цифровые технологии меняют фундаментальные аспекты производства и маркетинга в различных отраслях, включая образование. Наиболее трансформативное воздействие на бизнес-модели образовательных организаций потенциально могут оказать массовые открытые онлайн-курсы (МООК). Предлагая альтернативный и бесплатный доступ к образовательным услугам, они представляют собой угрозу для традиционных вузов. Однако одновременно МООК являются уникальным маркетинговым средством, создающим возможности для глобализации бренда, радикального увеличения клиентской базы и установления долгосрочных отношений с клиентами.Digital technologies influence the basic aspects of production and marketing in various sectors including education. Massive open online-courses (MOOCs) are probably the most powerful force transforming educational and business models of universities and other educational organizations. Providing an alternative and free access to educational services, they threaten many traditional universities. But at the same time they provide new and unique marketing opportunities for global branding, extension of customer base and establishment long-term relations with their customers.
Reconstruction of B cell lineages
Creators: name: Schaik, Barbera Van
name: Doorenspleet, Marieke E
name: Klarenbeek, Paul L
name: Esveldt, Rebecca EE
name: Vries, Niek De
name: Kampen, Antoine HC Van
Publisher: name: F1000Research
Year: 2015

description: T and B cells of the adaptive immune system are highly specialized cells that orchestrate a targeted attack against pathogens. Variability in the T and B cell repertoire is introduced by somatic rearrangement of the receptor genes to recognize many antigens. In addition, B cells can increase their specificity by mutating their receptor to improve recognition of the antigen. Understanding this process might greatly enhance our understanding of immune responses in health and disease.

We will present a method to reconstruct the mutation events of B cell receptors (BCR) from sequencing data. The resulting lineage tree is represented as a directed graph were the nodes represent unique BCR sequences and the edges the parent-child relation. The properties of such trees have been shown to correlate with biological processes in the past.

We have used the mutation positions within sequences to determine parent-child relationships and gathered more evidence for a relation by using every sequence as reference once. With our method we were able to obtain reconstructed trees that were 94-100\% similar to simulated trees, which is a result we couldn't obtain when using distance based methods alone or by performing a single pass comparison between all sequences with an outgroup.

The tree reconstruction method will be used to analyze the B cell repertoire of patients with an auto-immune disease to see if the mutation process is different compared to healthy individuals. This method might also be useful for the analysis of other somatic mutation events, for example in tumor material.
Σχεδιασμός και απόδοση ηλιακά υποβοηθούμενου συστήματος θέρμανσης θερμοκηπίου με αβαθή γεωθερμία
Creators: name: Φιρφιρής, Βασίλειος Κωνσταντίνου
Publisher: name: Aristotle University of Thessaloniki
Year: 2013
Subjects: Αβαθής γεωθερμία
Θέρμανση θερμοκηπίου
Shallow geothermal energy
Heating
Greenhouse

description: Στην παρούσα εργασία εξετάζεται η δυνατότητα, θέρμανσης θερμοκηπίου με ένα σύστημα αβαθούς γεωθερμίας. Ένα θερμοκήπιο απαιτεί πρόσθετη θέρμανση κατά τις χειμερινούς μήνες ώστε να διατηρήσει τις επιθυμητές συνθήκες στο εσωτερικό του .Τα συστήματα αβαθούς γεωθερμίας αξιοποιούν τη θερμική ενέργεια που βρίσκεται σε μικρά βάθη από την επιφάνεια του εδάφους και οφείλονται κατά κύριο λόγο στην ηλιακή ακτινοβολία. Η μελέτη επικεντρώνεται στο σχεδιασμό και τη διαστασιολόγηση ενός τέτοιου συστήματος, στα περιβαλλοντικά οφέλη- καθώς και στο κατά πόσο είναι οικονομικά σκόπιμη η εγκατάσταση του. Επιπλέον εξετάζεται η δυνατότητα βελτίωσης των θερμικών ιδιοτήτων του εδάφους με την αξιοποίηση του μικροκλίματος που διαμορφώνεται στο εσωτερικό του θερμοκηπίου που λειτουργεί ως ένας μεγάλος ηλιακός συλλέκτης. Η αύξηση της θερμοκρασίας του εδάφους μακροπρόθεσμα μπορεί να βελτιώσει την απόδοση του γεωεναλλάκτη συνεπώς και το συνολικό βαθμό απόδοσης του συστήματος με ότι αυτό συνεπάγεται από ενεργειακής και περιβαλλοντικής απόψεως. Τέλος στο πρώτο κομμάτι της διατριβής γίνεται μία επισκόπηση των χρήσεων και εφαρμογών γενικότερα της γεωθερμικής ενέργειας, επικεντρώνοντας κυρίως στο κομμάτι των αγροτικών εφαρμογών.
description: In the present study the possibility of heating a greenhouse with a shallow geothermal system is examined. A greenhouse requires additional heating during the winter months to maintain the desired conditions for proper growth of the crop. Shallow geothermal systems utilize the thermal energy at shallow depths from the soil surface which are mainly due to solar radiation. The study focuses on the design and dimensioning of such a system, the environmental benefits-as well as whether it is economically feasible to install. Further step is the improvement of the thermal properties of soil by exploiting the microclimate formed inside the greenhouse- that acts as a large solar collector. The increase of soil temperature can improve the performance of the ground heat exchanger and thus the overall efficiency of the system. That leads to an improvement of the energy, environmental and economical performance of the system . Finally the first part of the thesis deals with an overview of the uses and applications of geothermal energy in general, focusing mainly on the piece of rural applications.
RAQOBAT HUQUQIDA KAMSITUVCHI SHART-SHAROITLAR
Creators: name: Razzaqova, E'zoza
Publisher: name: Zenodo
Year: 2024

description: Mazkur tezisda raqobat maydonida ma’lum bir ustun mavqega ega bo’lgan subyektlarning shartnoma shartlariga kamsituvchi bandlari kiritish holatlari va ularning oqibatlari haqida, kamsituvchi shart sharoitlarga misol keltirgan holda ko’rib chiqamiz.
Μελέτη της φωτοκαταλυτικής διάσπασης της χρωστικής Nuclear Fast Red σε υδατικά διαλύματα
Creators: name: Δελετζέ, Ευγενία Θωμά
Publisher: name: Aristotle University of Thessaloniki
Year: 2013
Subjects: Φωτοκαταλυτική διάσπαση
Χρωστική ουσία
Διοξείδιο του Τιτανίου
Photocatalytic Degradation
Nuclear Fast Red
TiO2

description: Η φωτοκαταλυτική διάσπαση υδατικών διαλυμάτων της χρωστικής ουσίας Nuclear Fast Red (NFR), μιας τυπικής ανθρακινόνης, μελετήθηκε με χρήση καταλύτη TiO2 και τεχνητής ή ορατής (>400nm) ακτινοβολίας. Βρέθηκε ότι όταν χρησιμοποιείται ηλιακή ακτινοβολία, η διάσπαση των μορίων της NFR λαμβάνει χώρα στην επιφάνεια του φωτοκαταλύτη μέσω μιας σειράς βημάτων οξείδωσης που οδηγούν στο σχηματισμό ενδιαμέσων, τα οποία στη συνέχεια οξειδώνονται περαιτέρω προς ενώσεις με προοδευτικό μικρότερο μοριακό βάρος. Τελικά, επιτυγχάνεται πλήρης αποικοδόμηση της αν-θρακινόνης, με σχηματισμό CO2 στην αέρια φάση και ανόργανα ιόντα στο διάλυμα. Σύμφωνα με τα αποτελέσματα της κινητικής μελέτης του συστήμα-τος, ο αρχικός ρυθμός αποχρωματισμού εξαρτάται από την ένταση και το μήκος κύματος της προσπίπτουσας ακτινοβολίας, από την κάλυψη της επι-φάνειας, από την αρχική συγκέντρωση της ανθρακινόνης, από τη συγκέν-τρωση του TiO2 και από το αρχικό pH.
description: The photocatalytic degradation of aqueous solutions of Nuclear Fast Red (NFR), an anthracinone-dye, is investigated with the use of TiO2 photocatalyst and artificial solar or visible (>400nm) light irradiation. It was shown that when the full solar spectrum is utilized, the dye molecules ab-sorbed on TiO2 surface undergo a series of oxidation steps, which lead to rapid decolorization and formation of a number of intermediates, which are further oxidized toward compounds of progressively lower molecular weight and eventually, to CO2 and inorganic ions. kinetic results show that the initial rate of decolorization depends on the intensity and the wavelength of incident light irradiation, the surface coverage, the initial concentration of the anthracinone-dye, the concentration of the photocatalyst and the initial pH of the solution.
РОЛЬ ФТС РОССИИ В ОСУЩЕСТВЛЕНИИ ВАЛЮТНОГО КОНТРОЛЯ
Creators: name: О.А. Майсак
name: К.А. Жильцова
name: Р.Р. Ахмедзянов
Publisher: name: Экономика и бизнес: теория и практика
Year: 2021
Subjects: валютный контроль
таможенные органы
органы валютного контроля
участник внешнеэкономической деятельности
валюта
валютные операции
валютные ценности.

description: Валютный контроль является ключевым средством достижения главных целей валютной политики государства, одной из которых является устранение нелегального вывоза капитала. В статье анализируется деятельность ФТС России в сфере валютного контроля, рассматривается взаимодействие с другими государственными органами и определяется ее роль в данном процессе. Также в статье приводятся некоторые проблемы валютного контроля в России.
Anomalies of the Achucarro-Ortiz black hole
Creators: name: Xiao, Kui
name: Liu, Wenbiao
name: Zhang, Hongbao
Publisher: name: arXiv
Year: 2007
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Considering anomalies of quantum field in the (1+1)-dimensional Achucarro-Ortiz black hole background, the stress tensor near and out of the horizon is calculated, meanwhile, the relationship between anomalies and Hawking radiation of the black hole is discussed.
description: 6 pages
MUALLIF MUSHOHADASINI IFODALOVCHI SEMANTIK-STILISTIK VOSITALAR
Creators: name: Xamroyeva, Shaxzoda
Publisher: name: Zenodo
Year: 2024

description: XX asrning ikkinchi yarmida tilshunoslikka antroposentrik yondashuv asosida kognitiv tilshunoslik vujudga keldi shu bilan birga matn ortidagi muallif mushohasining kognitiv talqiniga oid ilmiy izlanishlar ko’zga tashlandi. Dissertatsiyamizning maqsadidan kelib chiqib muallif mushohadasi termini kiritildi va bu bizga ushbu hodisani yanada kengroq ya’ni adabiy tushuncha hisoblangan muallif chekinishini “muallif mushohadasi” termini ostida tilshunoslikning badiiy diskurs nuqtai nazaridan semantik-stilistik, struktur va kognitiv aspektida ko'rib chiqishga imkon beradi.
DeepCervix: A Deep Learning-based Framework for the Classification of Cervical Cells Using Hybrid Deep Feature Fusion Techniques
Creators: name: Rahaman, Md Mamunur
name: Li, Chen
name: Yao, Yudong
name: Kulwa, Frank
name: Wu, Xiangchen
name: Li, Xiaoyan
name: Wang, Qian
Publisher: name: arXiv
Year: 2021
Subjects: subject: Image and Video Processing (eess.IV)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences

description: Cervical cancer, one of the most common fatal cancers among women, can be prevented by regular screening to detect any precancerous lesions at early stages and treat them. Pap smear test is a widely performed screening technique for early detection of cervical cancer, whereas this manual screening method suffers from high false-positive results because of human errors. To improve the manual screening practice, machine learning (ML) and deep learning (DL) based computer-aided diagnostic (CAD) systems have been investigated widely to classify cervical pap cells. Most of the existing researches require pre-segmented images to obtain good classification results, whereas accurate cervical cell segmentation is challenging because of cell clustering. Some studies rely on handcrafted features, which cannot guarantee the classification stage's optimality. Moreover, DL provides poor performance for a multiclass classification task when there is an uneven distribution of data, which is prevalent in the cervical cell dataset. This investigation has addressed those limitations by proposing DeepCervix, a hybrid deep feature fusion (HDFF) technique based on DL to classify the cervical cells accurately. Our proposed method uses various DL models to capture more potential information to enhance classification performance. Our proposed HDFF method is tested on the publicly available SIPAKMED dataset and compared the performance with base DL models and the LF method. For the SIPAKMED dataset, we have obtained the state-of-the-art classification accuracy of 99.85%, 99.38%, and 99.14% for 2-class, 3-class, and 5-class classification. Moreover, our method is tested on the Herlev dataset and achieves an accuracy of 98.32% for binary class and 90.32% for 7-class classification.
description: 12 pages, 8 figures, Published in Computers in Biology and Medicine
Examining the effect of technology enhanced learning (TEL) support models and organisational culture on the adoption of TEL in United Kingdom (UK) higher education
Creators: name: Voce, Julie
Publisher: name: Lancaster University
Year: 2019
Subjects: Technology Enhanced Learning (TEL)
Organisational Culture
higher education
support models
support structures

description: Using a three-stage explanatory sequential design approach, this thesis examined the effectiveness of support for technology enhanced learning (TEL) within United Kingdom (UK) higher education (HE) institutions and the role of organisational culture on successful adoption of TEL. The research is framed within the perspective of institutional heads of TEL. Data were collected via a survey of 33 institutional representatives from the Heads of e-Learning Forum, followed up by in-depth interviews with five heads of TEL. The initial findings were discussed and verified via an open TweetChat with 24 participants in TEL support roles, including heads of TEL, and through a directed content analysis of the Universities and Colleges Information Systems Association (UCISA) TEL Case Studies. The findings identified a predominant TEL support model within UK HE as having a primary TEL team based in a central department, often working in conjunction with other central teams supporting TEL and alongside some local TEL support, typically unconnected from the primary TEL team. TEL support initially evolved organically within institutions; more recently there has been a shift towards planned re-organisation of TEL support. The research identified three key factors relevant to successful adoption of TEL: 1. size and location of TEL support teams; 2. how institutions identify and support local needs, and 3. governance structures for TEL. The findings also discussed the role of organisational culture on the successful adoption of TEL and identified two key factors relating to discipline specific needs and the role of influential people. One output of this thesis is the development of a draft Framework for Action, which is a set of self-reflexive, evaluative questions based on the factors identified in the research to enable heads of TEL or senior managers to reflect on their TEL support model and identify areas for change.
Μαθηματική Νόηση: μελέτη νευροφυσιολογικών δεικτών ικανών να περιγράψουν τη δυσκολία μαθηματικών προβλημάτων
Creators: name: Στεφανίδης, Βασίλειος Κυριάκου
Publisher: name: Aristotle University of Thessaloniki
Year: 2013
Subjects: subject: Νόηση
subject: Μαθηματικά
subject: Νευροφυσιολογία
subject: Εγκέφαλος
subject: Ηλεκτροεγκεφαλογράφημα
subject: Cognition
subject: Mathematics
subject: FOS: Mathematics
subject: Neurophysiology
subject: Brain
subject: Electroegephalography

description: Η συγκεκριμένη εργασία έχει σκοπό να ερευνήσει τον τρόπο αντίδρασης του ανθρώπινου εγκεφάλου σε μαθηματικά ερεθίσματα κλιμακωτής δυσκολίας. Πιο συγκεκριμένα από τη μελέτη της εγκεφαλικής αντίδρασης ζητείται η διερεύνηση ύπαρξης δεικτών οι οποίοι είναι ικανοί να περιγράψουν τη βαθμωτή δυσκολία ενός μαθηματικού προβλήματος. Η παρούσα μελέτη αφορά φυσιολογικά άτομα και ως μέσω έρευνας της εγκεφαλικής αντίδρασης θα χρησιμοποιηθεί το ηλεκτροεγκεφαλογράφημα (ΗΕΓ). Στους συμμετέχοντες της παρούσας έρευνας θα δοθούν ως μαθηματικά ερεθίσματα οι ακόλουθες μαθηματικές πράξεις: i) πρόσθεση μονοψήφιων αριθμών, ii) πολλαπλασιασμός μονοψήφιων αριθμών, iii) πρόσθεση διψήφιων αριθμών και iv) πολλαπλασιασμός διψήφιων αριθμών. Έπειτα από τις ΗΕΓ καταγραφές θα εξαχθεί μια σωρεία νευροφυσιολογικών δεικτών και με την χρήση αλγορίθμων και τεχνικών εξόρυξης γνώσης θα επιλεχθούν οι δείκτες που είναι ικανοί να περιγράψουν καλύτερα την διαφοροποίηση της εγκεφαλικής αντίδρασης σε μαθηματικά προβλήματα κλιμακωτής δυσκολίας.
description: The subject of this postgraduate thesis is how the human brain responds to mathematical stimuli with scalable difficulty. More specifically from cortical reactions, we investigated various indexes which are able to describe the scalable difficulty of mathematic problems, that the brain tries to solve the specific time. The present study concerns physiologic individuals. We implemented electroencephalography (EEG) method in those subjects in order to study the mathematical reactions, while they had been stimulated by the following maths : i) one digit addition, ii) one digit multiplication, iii) double digit addition and finally iv) double digit multiplication. After processing EEG recordings, we extracted a big amount of feature vectors. Then, by using classification algorithms and data mining methods, we found good models in order to predict and describe the differentiations of brain reaction in various math problems with scalable difficulty.
title: Knowing and caring
title: performing legitimacy in neighbourhood planning
titleType: Subtitle
Creators: name: Yuille, Andrew
Publisher: name: Lancaster University
Year: 2019
Subjects: Neighbourhood planning
Science and Technology Studies (STS)
identity and representation
Evidence
Care
expertise and lay knowledge

description: Neighbourhood Planning is a form of small-scale, community-led land-use planning, introduced to England by the Localism Act 2011. It constitutes a radical shift for UK planning and a striking example of the participatory and localist turns in governance, allowing ‘laypeople’ to write their own statutory planning policies. Its promoters portray it as a straightforward transfer of power from state to community which prioritises local experiential knowledge and care for place. However, drawing on theoretical and methodological resources from Science and Technology Studies and four years of ethnographic fieldwork at two sites in the North West of England, my research suggests a more complex picture. I show how the practices of Neighbourhood Planning reproduce the category of the expert and the expert-agency coupling by producing a new subset of lay-experts. However, they occupy a precarious position, being reliant on established expertise to stabilise their expert identity, but also subject to displacement by that expertise. They must also perform other identities alongside that of the expert to establish and maintain their legitimacy, and powerful tensions arise between these identities. Successfully enacting this composite of identities enables them to draw on complex, hybrid forms of representative, participatory, and epistemological authority. This constrains their ability to represent the neighbourhood as experienced and forces them to reframe the issues that they want to address, but also enables them to make real differences to the ways in which the neighbourhood will change. Framing the production and evaluation of evidence in terms of ‘matters of concern’ (Latour) and ‘matters of care’ (Puig de la Bellacasa), situated in a narrative context, would enable the diversity of things that matter to these groups to be addressed more directly, and allow better critical consideration of both those knowledge claims labelled as ‘objective’ and those labelled as ‘subjective’.
СИСТЕМА ВАЛЮТНОГО РЕГУЛИРОВАНИЯ РОССИЙСКОЙ ФЕДЕРАЦИИ И НАПРАВЛЕНИЯ ЕЁ РАЗВИТИЯ
Creators: name: Т.З. Сейдаметова
name: С.Х. Габдуллина
name: Н.В. Мельник
name: Р.Р. Ахмедзянов
Publisher: name: Экономика и бизнес: теория и практика
Year: 2021
Subjects: Валютное регулирование
участник внешнеэкономической деятельности
валюта
валютные операции
валютные ценности
спекулятивный капитал
валютный курс.

description: Эффективность функционирования национальной экономики в системе мирохозяйственных связей, предполагает выработку каждой страной собственной валютной политики. Валютное регулирование является одним из основных средств реализации валютной политики государства. Валютное регулирование определяется как деятельность государственных органов, направленная на регламентирование порядка совершения валютных операций. Значимость системы валютного регулирования, наличие проблем в этой сфере и необходимость их решения, перспективы и направления ее дальнейшего развития свидетельствуют об актуальности исследований в этом направлении. В статье проведен анализ функционирования системы валютного регулирования в России и сформулированы направления ее развития.
Intrinsic versus super-rough anomalous scaling in spontaneous imbibition
Creators: name: Pradas, M.
name: Hernández-Machado, A.
Publisher: name: arXiv
Year: 2006
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: We study spontaneous imbibition using a phase field model in a two dimensional system with a dichotomic quenched noise. By imposing a constant pressure $μ_{a}<0$ at the origin, we study the case when the interface advances at low velocities, obtaining the scaling exponents $z=3.0\pm 0.1$, $α=1.50\pm 0.02$ and $α_{loc}= 0.95\pm 0.03$ within the intrinsic anomalous scaling scenario. These results are in quite good agreement with experimental data recently published. Likewise, when we increase the interface velocity, the resulting scaling exponents are $z=4.0 \pm 0.1$, $α=1.25\pm 0.02$ and $α_{loc}= 0.95\pm 0.03$. Moreover, we observe that the local properties of the interface change from a super-rough to an intrinsic anomalous description when the contrast between the two values of the dichotomic noise is increased. From a linearized interface equation we can compute analytically the global scaling exponents which are comparable to the numerical results, introducing some properties of the quenched noise.
description: Accepted for publication in Physical Review E
Codes for "Heatwave future changes from an ensemble of km-scale regional climate simulations within CORDEX-FPS convection"
Creators: name: Sangelantoni, Lorenzo
Publisher: name: Zenodo
Year: 2024

description: Repository of codes to derive and analyze several heatwave metrics during historical and future periods. Codes have been developed for assessing the impact of convection-permitting resolution in the representation of heatwaves. They are designed for climate simulations performed in the CORDEX FPS Convection (Coppola et al., 2020).
Εκτιμήσεις κυρτού ολοκληρωτικού μέσου αρμονικών
Creators: name: Κελγιάννης, Γεώργιος Σωτηρίου
Publisher: name: Aristotle University of Thessaloniki
Year: 2013
Subjects: αρμονικές
εκτιμήσεις
αναδιατάξεις
harmonic
estimates
rearrangements

description: Σκοπός της διατριβής ήταν η παρουσίαση δύο θεωρημάτων που είχαν πρόσφατα αποδειχτεί και αφορούσαν τον κυρτό ολοκληρωτικό μέσο μιας αρμονικής συνάρτησης. Για το σκοπό αυτό παρουσιάσαμε κάποια σημεία της θεωρίας των αρμονικών συναρτήσεων με έμφαση στο Λήμμα Schwarz. Παρουσιάσαμε επίσης τη θεωρία των αναδιατάξεων συναρτήσεων, μαζι με κάποια αναγκαία λήμματα που αφορούσαν τις αναδιατάξεις. Τέλος δώσαμε αναλυτικά τις αποδείξεις των δύο θεωρημάτων.
description: The aim of the present thesis was the presentation of two recently proved theorems regarding the convex integral means of harmonic functions. For this purpose we presented some points from Harmonic Function Theory, with emphasis to the Schwarz Lemma. We also presented the theory of rearrangements, along with some necessary lemmas regarding symmetrizations. Finally we gave thorough proofs of both theorems.
Extracellular SQSTM1 exacerbates acute pancreatitis by activating autophagy-dependent ferroptosis
Creators: name: Yang, Liangchun
name: Ye, Fanghua
name: Liu, Jiao
name: Klionsky, Daniel J.
name: Tang, Daolin
name: Kang, Rui
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Neuroscience
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Acute pancreatitis (AP) is an abdominal inflammatory disease initiated by damaged pancreatic acinar cells and developed by systemic inflammation. SQSTM1 (sequestosome 1) has an intracellular function in mediating substrate degradation during macroautophagy/autophagy, and it can be released by macrophages and monocytes to trigger lethal inflammation during bacterial infection. Here, we report that extracellular SQSTM1 acts as a mediator of AP by enhancing the sensitivity to autophagy-dependent ferroptotic cell death. Serum SQSTM1 is elevated in AP patients as well as in mice that have cerulein-induced AP. The administration of SQSTM1-neutralizing antibodies protects against experimental AP in mice. Mechanistically, recombinant SQSTM1 protein (rSQSTM1) increases AGER (advanced glycosylation end-product specific receptor)-dependent ACSL4 (acyl-CoA synthetase long chain family member 4) expression, leading to polyunsaturated fatty acid production for autophagosome formation and subsequent ferroptosis. The rSQSTM1-elicited pathological responses during AP are attenuated in mice with the conditional deletion of Ager in the pancreas. These findings may provide not only new insights into the mechanism of autophagy-dependent cell death, but also suggest that targeting the extracellular SQSTM1 pathway is a potential strategy for the treatment of AP. 5-HETE, 5-hydroxyeicosatetraenoic acid; ACSL4, acyl-CoA synthetase long chain family member 4; AP, acute pancreatitis; ATG, autophagy related; AGER, advanced glycosylation end-product specific receptor; DAMPs, danger/damage-associated molecular patterns; FTH1, ferritin heavy chain 1; GPX4, glutathione peroxidase 4; IL, interleukin; INSR, insulin receptor; MAP1LC3B, microtubule associated protein 1 light chain 3 beta; MDA, malondialdehyde; MPO, myeloperoxidase; PRRs, pattern recognition receptors; PUFA, polyunsaturated fatty acid; RNAi, RNA interference; SQSTM1, sequestosome 1; TNF, tumor necrosis factor; TLR, toll like receptor