cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Four-parameter paired response curve for serial dilution assays
Creators: name: Fong, Youyi
name: Permar, Sallie R.
name: Tomaras, Georgia D.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: Computational Biology

description: Newer immunoassay platforms offer improved signal-to-noise ratio but are more expensive. Thus, it is more cost efficient to perform these assays at a few selected, rather than a full series of, sample dilutions. We propose a new four-parameter paired response curve to model the relationship between assay outcomes from two sample dilutions and study likelihood-based inference. Given a fitted paired response curve, we can predict assay outcomes for de novo dilutions of samples, which enables cross-protocol comparison of immune response biomarkers even when different protocols use different sample dilutions. Numerical studies on both simulated and real data are presented.
Recent Increases in Tasmanian Huon Pine Ring Widths from a Subalpine Stand: Natural Climate Variability, CO2 Fertilisation, or Greenhouse Warming?
Creators: Cook, Edward R.
Francey, R. J.
Buckley, Brendan M.
D'Arrigo, Rosanne Dorothy
Publisher: name: Columbia University
Year: 1996
Subjects: Dendroclimatology
Huon pine
Paleoclimatology
Botany
Climatic changes

description: Tasmanian subalpine Huon pines from the extreme high-altitude limit of the species distribution provide a summer temperature reconstruction extending back beyond 800 Be. Compared to low elevation Huon pine sites, the subalpine ring-widths exhibit a straightforward direct response to current growth-season temperatures and indicate anomalous warming of 0.33 ± O.06°C from 1967- 91. This warming is consistent with Tasmanian instrumental records and with hemispheric and global records. The possibility that the trees are responding directly to CO2 fertilisation is explored, using a high-precision record of CO2, obtained from air in Antarctic ice and firn, plus direct measurements of air from Cape Grim. The temperature forcing appears capable of explaining the ring-width variations in the alpine trees over the full range of observed periods, whereas CO2 fertilisation would require a more complex interaction and is not supported by other arguments. Two millennia-long tree-ring reconstructions of summer temperatures from South America do not exhibit the recent warming, nor other features found in the Tasmanian record on decadal to century time-scales. In fact, the South American chronologies bear little resemblance to each other, but do, however, reflect their own regional instrumental records. The Mt Read ring-width chronology, and the instrumental temperature series used for its calibration, also co-vary with climate influences of a distinctly regional character, yet still replicate many of the features reported as hemispheric and global temperatures over the last century. Spectral analysis of the Mt Read tree-ring data over the full 2,792 years suggests that at least part of the recent warming in the instrumental records could be a consequence of "natural forcing" of the record, complicating an interpretation in terms of a greenhouse-forced warming.
Street Audits to Measure Neighborhood Disorder: Virtual or In-Person?
Creators: name: Sheehan, D.M.
name: Galea, S.
name: Goldmann, E.
name: Aiello, A.E.
name: Lovasi, G.S.
name: Teitler, J.O.
name: Mooney, S.J.
name: Bader, M.D.M.
name: Rundle, A.G.
name: Koenen, K.C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Neighborhood conditions may influence a broad range of health indicators, including obesity, injury, and psychopathology. In particular, neighborhood physical disorder - a measure of urban deterioration - is thought to encourage crime and high-risk behaviors, leading to poor mental and physical health. In studies to assess neighborhood physical disorder, investigators typically rely on time-consuming and expensive in-person systematic neighborhood audits. We compared 2 audit-based measures of neighborhood physical disorder in the city of Detroit, Michigan: One used Google Street View imagery from 2009 and the other used an in-person survey conducted in 2008. Each measure used spatial interpolation to estimate disorder at unobserved locations. In total, the virtual audit required approximately 3% of the time required by the in-person audit. However, the final physical disorder measures were significantly positively correlated at census block centroids (r = 0.52), identified the same regions as highly disordered, and displayed comparable leave-one-out cross-validation accuracy. The measures resulted in very similar convergent validity characteristics (correlation coefficients within 0.03 of each other). The virtual audit-based physical disorder measure could substitute for the in-person one with little to no loss of precision. Virtual audits appear to be a viable and much less expensive alternative to in-person audits for assessing neighborhood conditions.
title: Speeches by Secretary of Transportation Samuel K. Skinner: July-December 1991
Creators: name: Skinner, Samuel  1938-
name: United States Department of Transportation
Publisher: name: United States Department of Transportation
publisherIdentifier: https://ror.org/02xfw2e90
publisherIdentifierScheme: ROR
Year: 1991
Subjects: classificationCode: https://trt.trb.org/term/87904
subject: Transportation
classificationCode: https://trt.trb.org/term/89768
subject: Transportation planning
classificationCode: https://trt.trb.org/term/88891
subject: Transportation policy
classificationCode: https://trt.trb.org/term/90595
subject: Transportation safety
classificationCode: https://trt.trb.org/term/91422
subject: Economic and social factors
classificationCode: https://trt.trb.org/term/92116
subject: Federal government
classificationCode: https://trt.trb.org/term/92130
subject: Transportation departments

description: One zipped folder containing digitized PDFs. See the Secretary of Transportation Speeches Collection's finding aid at: https://ntl.as.atlas-sys.com/repositories/2/resources/4
description: Speeches by Secretary of Transportation Samuel K. Skinner from July 1991 through December 1991.
Aspects of warm-flat directions
Creators: name: Matsuda, Tomohiro
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Considering the mechanism of dissipative slow-roll that has been used in warm inflation scenario, we show that dissipation may alter usual cosmological scenarios associated with SUSY-flat directions. We mainly consider SUSY-flat directions that have strong interactions with non-flat directions and may cause strong dissipation both in thermal and non-thermal backgrounds. An example is the Affleck-Dine mechanism in which dissipation may create significant (both qualitative and quantitative) discrepancies between the conventional scenario and the dissipative one. We also discuss several mechanisms of generating curvature perturbations in which the dissipative field, which is distinguished from the inflaton field, can be used as the source of cosmological perturbations. Considering the Morikawa-Sasaki dissipative coefficient, the damping caused by the dissipation may be significant for many MSSM flat directions even if the dissipation is far from thermal equilibrium.
description: 22 pages, accepted for publication in International Journal of Modern Physics A
Invited commentary: Evolution of social networks, health, and the role of epidemiology
Creators: name: Aiello, A.E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Almost 40 years ago, Berkman and Syme demonstrated that social networks were related to the risk of early mortality (Am J Epidemiol. 1979;109(2):186-204). Their study was highly innovative because they directly measured and quantified social networks in a large prospective population-based survey with mortality follow-up. The results of the study showed robust network gradients, whereby those with fewer networks and weaker social ties had significantly higher mortality rates. The important influence of social networks that Berkman and Syme noted many years ago is likely to heighten in the future, as demographic characteristics shift and individuals become more inclined to socialize through online platforms instead of real-world interactions. Berkman and Syme's research in 1979 continues to play a key role in shaping recent efforts to uncover the influence of social networks on health. Looking back on their findings may help epidemiologists better understand the importance of both online and offline networks for population health today.
On the spinfoam expansion in cosmology
Creators: name: Rovelli, Carlo
name: Vidotto, Francesca
Publisher: name: arXiv
Year: 2009
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We consider the technique introduced in a recent work by Ashtekar, Campiglia and Henderson, which generate a spinfoam-like sum from a Hamiltonian theory. We study the possibility of using it for finding the generalized projector of a constraint on physical states, without first deparametrising the system. We illustrate this technique in the context of a very simple example. We discuss the infinities that appear in the calculation, and argue that they can be appropriately controlled. We apply these ideas to write a spinfoam expansion for the "dipole cosmology".
description: 6 pages (typos corrected)
Precipitation, Temperature, and Teleconnection Signals across the Combined North American, Monsoon Asia, and Old World Drought Atlases
Creators: Baek, Seung Hun
Smerdon, Jason E.
Coats, Sloan John
Williams, A. Park
Cook, Benjamin I.
Cook, Edward R.
Seager, Richard
Publisher: name: Columbia University
Year: 2017
Subjects: Climatic changes
Climatic changes--Models
Hydrologic models--Evaluation

description: The tree-ring-based North American Drought Atlas (NADA), Monsoon Asia Drought Atlas (MADA), and Old World Drought Atlas (OWDA) collectively yield a near-hemispheric gridded reconstruction of hydroclimate variability over the last millennium. To test the robustness of the large-scale representation of hydroclimate variability across the drought atlases, the joint expression of seasonal climate variability and teleconnections in the NADA, MADA, and OWDA are compared against two global, observation-based PDSI products. Predominantly positive (negative) correlations are determined between seasonal precipitation (surface air temperature) and collocated tree-ring-based PDSI, with average Pearson’s correlation coefficients increasing in magnitude from boreal winter to summer. For precipitation, these correlations tend to be stronger in the boreal winter and summer when calculated for the observed PDSI record, while remaining similar for temperature. Notwithstanding these differences, the drought atlases robustly express teleconnection patterns associated with El Niño–Southern Oscillation (ENSO), the North Atlantic Oscillation (NAO), the Pacific decadal oscillation (PDO), and the Atlantic multidecadal oscillation (AMO). These expressions exist in the drought atlas estimates of boreal summer PDSI despite the fact that these modes of climate variability are dominant in boreal winter, with the exception of the AMO. ENSO and NAO teleconnection patterns in the drought atlases are particularly consistent with their well-known dominant expressions in boreal winter and over the OWDA domain, respectively. Collectively, the findings herein confirm that the joint Northern Hemisphere drought atlases robustly reflect large-scale patterns of hydroclimate variability on seasonal to multidecadal time scales over the twentieth century and are likely to provide similarly robust estimates of hydroclimate variability prior to the existence of widespread instrumental data.
title: Speeches by Secretary of Transportation Rodney E. Slater: August-December 1997
Creators: name: Slater, Rodney E.
name: United States Department of Transportation
Publisher: name: United States Department of Transportation
publisherIdentifier: https://ror.org/02xfw2e90
publisherIdentifierScheme: ROR
Year: 1997
Subjects: classificationCode: https://trt.trb.org/term/87904
subject: Transportation
classificationCode: https://trt.trb.org/term/89768
subject: Transportation planning
classificationCode: https://trt.trb.org/term/88891
subject: Transportation policy
classificationCode: https://trt.trb.org/term/90595
subject: Transportation safety
classificationCode: https://trt.trb.org/term/91422
subject: Economic and social factors
classificationCode: https://trt.trb.org/term/92116
subject: Federal government
classificationCode: https://trt.trb.org/term/92130
subject: Transportation departments

description: One zipped folder containing digitized PDFs. See the Secretary of Transportation Speeches Collection's finding aid at: https://ntl.as.atlas-sys.com/repositories/2/resources/4
description: Speeches by Secretary of Transportation Rodney E. Slater from August 1997 through December 1997.
Evolutionary Construction of Geographical Networks with Nearly Optimal Robustness and Efficient Routing Properties
Creators: name: Hayashi, Yukio
Publisher: name: arXiv
Year: 2008
Subjects: subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: Computational Geometry (cs.CG)
subject: Networking and Internet Architecture (cs.NI)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Robust and efficient design of networks on a realistic geographical space is one of the important issues for the realization of dependable communication systems. In this paper, based on a percolation theory and a geometric graph property, we investigate such a design from the following viewpoints: 1) network evolution according to a spatially heterogeneous population, 2) trimodal low degrees for the tolerant connectivity against both failures and attacks, and 3) decentralized routing within short paths. Furthermore, we point out the weakened tolerance by geographical constraints on local cycles, and propose a practical strategy by adding a small fraction of shortcut links between randomly chosen nodes in order to improve the robustness to a similar level to that of the optimal bimodal networks with a larger degree $O(\sqrt{N})$ for the network size $N$. These properties will be useful for constructing future ad-hoc networks in wide-area communications.
description: 14 pages, 10 figures, 1 table
Quantum algorithm for the Laughlin wave function
Creators: name: Latorre, J. I.
name: Picó, V.
name: Riera, A.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We construct a quantum algorithm that creates the Laughlin state for an arbitrary number of particles $n$ in the case of filling fraction one. This quantum circuit is efficient since it only uses $n(n-1)/2$ local qudit gates and its depth scales as $2n-3$. We further prove the optimality of the circuit using permutation theory arguments and we compute exactly how entanglement develops along the action of each gate. Finally, we discuss its experimental feasibility decomposing the qudits and the gates in terms of qubits and two qubit-gates as well as the generalization to arbitrary filling fraction.
description: 4 pages, 5 figures
An in-depth look into PTSD-depression comorbidity: A longitudinal study of chronically-exposed Detroit residents
Creators: name: Horesh, D.
name: Koenen, K.C.
name: Galea, S.
name: Uddin, M.
name: Aiello, A.E.
name: Lowe, S.R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Background Although PTSD-major depressive disorder (MDD) co-morbidity is well-established, the vast majority of studies have examined comorbidity at the level of PTSD total severity, rather than at the level of specific PTSD symptom clusters. This study aimed to examine the long-term associations between MDD and PTSD symptom clusters (intrusion, avoidance, hyperarousal), and the moderating role of gender in these associations. Methods 942 residents of urban Detroit neighborhoods were interviewed at 3 waves, 1 year apart. At each wave, they were assessed for PTSD, depression, trauma exposure, and stressful life events. Results At all waves, hyperarousal was the PTSD cluster most strongly correlated with MDD. For the full sample, a reciprocal relationship was found between MDD and all three PTSD clusters across time. Interestingly, the relative strength of associations between MDD and specific PTSD clusters changed over time. Women showed the same bidirectional MDD-PTSD pattern as in the entire sample, while men sometimes showed non-significant associations between early MDD and subsequent PTSD clusters. Limitations First, our analyses are based on DSM-IV criteria, as this was the existing edition at the time of this study. Second, although this is a longitudinal study, inferences regarding temporal precedence of one disorder over another must be made with caution. Conclusions Early identification of either PTSD or MDD following trauma may be crucial in order to prevent the development of the other disorder over time. The PTSD cluster of hyper-arousal may require special therapeutic attention. Also, professionals are encouraged to develop more gender-specific interventions post-trauma.
Calibration of a Liquid Xenon Detector with Kr-83m
Creators: name: Kastens, L. W.
name: Cahn, S. B.
name: Manzur, A.
name: McKinsey, D. N.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We report the preparation of a Kr-83m source and its subsequent use in calibrating a liquid xenon detector. Kr-83m atoms were produced through the decay of Rb-83 atoms trapped in zeolite molecular sieve and were then introduced into liquid xenon. Decaying Kr-83m nuclei were detected through liquid xenon scintillation. Conversion electrons with energies of 9.4 keV and 32.1 keV from the decay of Kr-83m were both observed. This calibration source will allow the characterization of the scintillation and ionization response of noble liquid detectors at low energies, highly valuable for the search for WIMP dark matter. Kr-83m may also be useful for measuring fluid flow dynamics, both to understand purification in noble liquid-based particle detectors, as well as for studies of classical and quantum turbulence in superfluid helium.
description: Minor edits to match published version
title: Speeches by Secretary of Transportation Rodney E. Slater: January-July 1997
Creators: name: Slater, Rodney E.
name: United States Department of Transportation
Publisher: name: United States Department of Transportation
publisherIdentifier: https://ror.org/02xfw2e90
publisherIdentifierScheme: ROR
Year: 1997
Subjects: classificationCode: https://trt.trb.org/term/87904
subject: Transportation
classificationCode: https://trt.trb.org/term/88891
subject: Transportation policy
classificationCode: https://trt.trb.org/term/89768
subject: Transportation planning
classificationCode: https://trt.trb.org/term/90595
subject: Transportation safety
classificationCode: https://trt.trb.org/term/91422
subject: Economic and social factors
classificationCode: https://trt.trb.org/term/92116
subject: Federal government
classificationCode: https://trt.trb.org/term/92130
subject: Transportation departments

description: One zipped folder containing digitized PDFs. See the Secretary of Transportation Speeches Collection's finding aid at: https://ntl.as.atlas-sys.com/repositories/2/resources/4
description: Speeches by Secretary of Transportation Rodney E. Slater from January 1997 through July 1997.
The 400d Galaxy Cluster Survey Weak Lensing Programme: I: MMT/Megacam Analysis of CL0030+2618 at z=0.50
Creators: name: Israel, Holger
name: Erben, Thomas
name: Reiprich, Thomas H.
name: Vikhlinin, Alexey
name: Hildebrandt, Hendrik
name: Hudson, Daniel S.
name: McLeod, Brian A.
name: Sarazin, Craig L.
name: Schneider, Peter
name: Zhang, Yu-Ying
Publisher: name: arXiv
Year: 2009
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The mass function of galaxy clusters at high redshifts is a particularly useful probe to learn about the history of structure formation and constrain cosmological parameters. We aim at deriving reliable masses for a high-redshift, high-luminosity sample of clusters of galaxies selected from the 400d survey of X-ray selected clusters. Here, we will focus on a particular object, CL0030+2618 at z=0.50 Using deep imaging in three passbands with the MEGACAM instrument at MMT, we show that MEGACAM is well-suited for measuring gravitational shear. We detect the weak lensing signal of CL0030+2618 at 5.8 sigma significance, using the aperture mass technique. Furthermore, we find significant tangential alignment of galaxies out to ~10 arcmin or >2r_200 distance from the cluster centre. The weak lensing centre of CL0030+2618 agrees with several X-ray measurements and the position of the brightest cluster galaxy. Finally, we infer a weak lensing virial mass of M_200=7.5 10^{14} M_sun for CL0030+2618. Despite complications by a tentative foreground galaxy group in the line of sight, the X-ray and weak lensing estimates for CL0030+2618 are in remarkable agreement. This study paves the way for the largest weak lensing survey of high-redshift galaxy clusters to date.
description: 32 pages, 24 figures, submitted to Astronomy & Astrophysics; fixed some LaTeX issues, now 30 pages v3: Improved version accepted by Astronomy & Astrophysics
IRONSperm: Sperm-templated soft magnetic microrobots
Creators: name: Magdanz, Veronika
name: Khalil, Islam S.M.
name: Simmchen, Juliane
name: Furtado, Guilherme P.
name: Mohanty, Sumit
name: Gebauer, Johannes
name: Xu, Haifeng
name: Klingner, Anke
name: Aziz, Azaam
name: Medina-Sánchez, Mariana
name: Schmidt, Oliver G.
name: Misra, Sarthak
Publisher: name: Washington, DC : American Association for the Advancement of Science
Year: 2020
Subjects: subject: microrobots
subject: minimally invasive surgery
subject: biohybrid
subject: 620

description: We develop biohybrid magnetic microrobots by electrostatic self-assembly of nonmotile sperm cells and magnetic nanoparticles. Incorporating a biological entity into microrobots entails many functional advantages beyond shape templating, such as the facile uptake of chemotherapeutic agents to achieve targeted drug delivery. We present a single-step electrostatic self-assembly technique to fabricate IRONSperms, soft magnetic microswimmers that emulate the motion of motile sperm cells. Our experiments and theoretical predictions show that the swimming speed of IRONSperms exceeds 0.2 body length/s (6.8 ± 4.1 µm/s) at an actuation frequency of 8 Hz and precision angle of 45°. We demonstrate that the nanoparticle coating increases the acoustic impedance of the sperm cells and enables localization of clusters of IRONSperm using ultrasound feedback. We also confirm the biocompatibility and drug loading ability of these microrobots, and their promise as biocompatible, controllable, and detectable biohybrid tools for in vivo targeted therapy.
The effect of exercise training on arterial stiffness, physical function and self-reported health in haemodialysis patients
Creators: name: Koh, PS
Publisher: name: University Of Tasmania
Year: 2023

description: Haemodialysis patients show reduced physical function and greater risk of increased arterial stiffness because of hypertension, metabolic disturbances, and vascular calcification. Exercise interventions potentially could improve their vascular risk profile. This randomized controlled study compared the effects of six months of supervised intradialytic exercise training versus home-based exercise training or usual care on arterial stiffness, physical function and self-reported health in 70 haemodialysis patients. Intradialytic-exercise patients trained three times/wk for six months on a cycle ergometer and home-based-exercise patients followed a walking program to achieve the same weekly physical activity. Usual-care patients received no specific intervention. Primary outcome measures were distance travelled during a six-minute walk test and aortic pulse wave velocity. Secondary outcome measures included augmentation index (augmentation pressure as a percentage of central pulse pressure), peripheral (brachial) and central blood pressures (measured noninvasively using radial tonometry), physical activity, and self-reported physical functioning. Following six months of exercise intervention, there were no significant differences between changes in six-minute walk test distance (intradialytic exercise, +14%; home-based exercise, +11%; usual care, +5%), pulse wave velocity (intradialytic exercise, ‚Äö-4%; home-based exercise, ‚Äö-2%; usual care, ‚Äö-5%), or any secondary outcome measure. In conclusion, there were no differences between intradialytic or home-based exercise training and usual care for vascular parameters, physical function or self-reported health in haemodialysis patients after the six-month intervention
Epigenome-wide association of PTSD from heterogeneous cohorts with a common multi-site analysis pipeline
Creators: name: Koenen, K.C.
name: Maihofer, A.X.
name: Ratanatharathorn, A.
name: Smith, A.K.
name: Ressler, K.J.
name: Kimbrel, N.A.
name: Stein, M.B.
name: Baker, D.G.
name: Vinkers, C.H.
name: Amstadter, A.B.
name: Boks, M.P.
name: Geuze, E.
name: Hauser, M.A.
name: Vermetten, E.
name: PGC PTSD Epigenetics Workgroup
name: Miller, M.W.
name: Rutten, B.P.F.
name: Nievergelt, C.M.
name: VA Mid-Atlantic MIRECC Workgroup
name: Bromet, E.
name: Mitchell, C.
name: Nugent, N.R.
name: Aiello, A.E.
name: Kuan, P.-F.
name: Garrett, M.E.
name: Ashley-Koch, A.E.
name: Beckham, J.C.
name: Dennis, M.
name: Guffanti, G.
name: Youssef, N.A.
name: Luft, B.J.
name: Kilaru, V.
name: Uddin, M.
name: Luft, B.J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Compelling evidence suggests that epigenetic mechanisms such as DNA methylation play a role in stress regulation and in the etiologic basis of stress related disorders such as Post traumatic Stress Disorder (PTSD). Here we describe the purpose and methods of an international consortium that was developed to study the role of epigenetics in PTSD. Inspired by the approach used in the Psychiatric Genomics Consortium, we brought together investigators representing seven cohorts with a collective sample size of N = 1147 that included detailed information on trauma exposure, PTSD symptoms, and genome-wide DNA methylation data. The objective of this consortium is to increase the analytical sample size by pooling data and combining expertise so that DNA methylation patterns associated with PTSD can be identified. Several quality control and analytical pipelines were evaluated for their control of genomic inflation and technical artifacts with a joint analysis procedure established to derive comparable data over the cohorts for meta-analysis. We propose methods to deal with ancestry population stratification and type I error inflation and discuss the advantages and disadvantages of applying robust error estimates. To evaluate our pipeline, we report results from an epigenome-wide association study (EWAS) of age, which is a well-characterized phenotype with known epigenetic associations. Overall, while EWAS are highly complex and subject to similar challenges as genome-wide association studies (GWAS), we demonstrate that an epigenetic meta-analysis with a relatively modest sample size can be well-powered to identify epigenetic associations. Our pipeline can be used as a framework for consortium efforts for EWAS.
Sensitivity and response of Bhutanese glaciers to atmospheric warming
Creators: Rupper, Summer
Schaefer, Joerg M.
Burgener, Landon K.
Koenig, Lora S.
Tsering, Karma
Cook, Edward R.
Publisher: name: Columbia University
Year: 2012
Subjects: Glaciology
Glaciers--Climatic factors
Global warming
Meltwater

description: Glacierized change in the Himalayas affects river-discharge, hydro-energy and agricultural production, and Glacial Lake Outburst Flood potential, but its quantification and extent of impacts remains highly uncertain. Here we present conservative, comprehensive and quantitative predictions for glacier area and meltwater flux changes in Bhutan, monsoonal Himalayas. In particular, we quantify the uncertainties associated with the glacier area and meltwater flux changes due to uncertainty in climate data, a critical problem for much of High Asia. Based on a suite of gridded climate data and a robust glacier melt model, our results show that glacier area and meltwater change projections can vary by an order of magnitude for different climate datasets. However, the most conservative results indicate that, even if climate were to remain at the present-day mean values, almost 10% of Bhutan's glacierized area would vanish and the meltwater flux would drop by as much as 30%. Under the conservative scenario of an additional 1°C regional warming, glacier retreat is going to continue until about 25% of Bhutan's glacierized area will have disappeared and the annual meltwater flux, after an initial spike, would drop by as much as 65%.
title: Speeches by Secretary of Transportation Rodney E. Slater: January-May 1998
Creators: name: Slater, Rodney E.
name: United States Department of Transportation
Publisher: name: United States Department of Transportation
publisherIdentifier: https://ror.org/02xfw2e90
publisherIdentifierScheme: ROR
Year: 1998
Subjects: classificationCode: https://trt.trb.org/term/87904
subject: Transportation
classificationCode: https://trt.trb.org/term/89768
subject: Transportation planning
classificationCode: https://trt.trb.org/term/88891
subject: Transportation policy
classificationCode: https://trt.trb.org/term/90595
subject: Transportation safety
classificationCode: https://trt.trb.org/term/91422
subject: Economic and social factors
classificationCode: https://trt.trb.org/term/92116
subject: Federal government
classificationCode: https://trt.trb.org/term/92130
subject: Transportation departments

description: One zipped folder containing digitized PDFs. See the Secretary of Transportation Speeches Collection's finding aid at: https://ntl.as.atlas-sys.com/repositories/2/resources/4
description: Speeches by Secretary of Transportation Rodney E. Slater from January 1998 through May 1998.
Moduli stabilization and SUSY breaking in heterotic orbifold string models
Creators: name: Dundee, Ben
name: Raby, Stuart
name: Westphal, Alexander
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In this paper we discuss the issues of supersymmetry breaking and moduli stabilization within the context of E_8 x E_8 heterotic orbifold constructions and, in particular, we focus on the class of "mini-landscape" models. In the supersymmetric limit, these models admit an effective low energy field theory with a spectrum of states and dimensionless gauge and Yukawa couplings very much like that of the MSSM. These theories contain a non-Abelian hidden gauge sector which generates a non-perturbative superpotential leading to supersymmetry breaking and moduli stabilization. We demonstrate this effect in a simple model which contains many of the features of the more general construction. In addition, we argue that once supersymmetry is broken in a restricted sector of the theory, then all moduli are stabilized by supergravity effects. Finally, we obtain the low energy superparticle spectrum resulting from this simple model.
description: LaTeX, v2: 57+1 pages, 4 figures, 8 Tables, added references; this version i) discusses volume moduli stabilization with exponentials of both sign (as sometimes mandated by modular invariance); ii) includes the anomalous U(1)_A D-term & the leading Coleman-Weinberg 1-loop correction into the MSSM soft masses to prevent tachyonic results;
Additional file 1 of Abplatin(IV) inhibited tumor growth on a patient derived cancer model of hepatocellular carcinoma and its comparative multi-omics study with cisplatin
Creators: name: Li, Xing
name: Zhang, Lingpu
name: Li, Tuo
name: Li, Shumu
name: Wu, Wenjing
name: Zhao, Lingyu
name: Xie, Peng
name: Yang, Jinqi
name: Li, Peipei
name: Zhang, Yangyang
name: Xiao, Haihua
name: Yu, Yingjie
name: Zhao, Zhenwen
Publisher: name: figshare
Year: 2022
Subjects: Biochemistry
Space Science
Cell Biology
Molecular Biology
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Developmental Biology
Cancer
Mental Health

description: Additional file 1: Figure S1. Synthesis route and chemical structures of CisPt(IV). Figure S2. Characterization of CisPt(IV) by ESI-MS (positive mode). Figure S3. X-ray photoelectron spectroscopy (XPS) analysis of sulfur element in CisPt(IV) (A) and Abplatin(IV) (B). Figure S4. In vitro anticancer activity of cisplatin, CisPt(IV), and Abplatin(IV). Figure S5. Total percentages of BEL-7404 cells that underwent apoptosis as determined by flow cytometery after treatment with various Pt-containing drugs. Figure S6. Blood physiological and biochemical indexes of mice treated by PBS, cisplatin, and Abplatin(IV). Figure S7. The representative total ion chromatograms (TIC) of lipids extracted from the BEL-7404 cells in the positive ion mode (A) and negative ion mode (B). Figure S8. The representative total ion chromatograms (TIC) of metabolites extracted from the BEL-7404 cells in the positive ion mode (A) and negative ion mode (B). Figure S9. PLS-DA plots for discriminating the PBS, cisplatin, and Abplatin(IV) group at the lipid level in BEL-7404 cells obtained by UPLC-ESI(+)-Orbitrap-MS (A) and UPLC-ESI(-)-Orbitrap-MS (B). Figure S10. PLS-DA plots for discriminating the PBS, cisplatin, and Abplatin(IV) group at the metabolite level in BEL-7404 cells obtained by UPLC-ESI(+)-Qrbitrap-MS (A) and UPLC-ESI(-)-Orbitrap-MS (B). Figure S11. (A) Differential lipids between PBS and cisplatin-treated cells. (B) Differential metabolites between PBS and cisplatin-treated cells. Figure S12. (A) Metabolite sets enrichment overview of differential cells affected by cisplatin compared with PBS. (B) Metabolite sets enrichment overview of differential cells affected by Abplatin(IV) compared with PBS. Table S1. IC50 values of various Pt-containing drugs on various cell lines. Table S2. The significant differential genes in Abplatin(IV) treated group (s) compared with the PBS group (c). Table S3. The differential lipids in Abplatin(IV) treated group (s) compared with the PBS group (c). Table S4. The common differential metabolites in Abplatin(IV) treated group (s2), cisplatin treated group (s1) compared with the PBS group (c). Table S5. The mainly differential metabolites in Abplatin(IV) treated group (s) compared with the PBS group (c).
A putative causal relationship between genetically determined female body shape and posttraumatic stress disorder
Creators: name: Morey, R.A.
name: Garrett, M.E.
name: Roberts, A.L.
name: Ratanatharathorn, A.
name: Kessler, R.C.
name: Gelernter, J.
name: Dalvie, S.
name: Hauser, M.A.
name: Almli, L.M.
name: Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup
name: Smoller, J.W.
name: Baker, D.G.
name: Ashley-Koch, A.E.
name: Chen, C.-Y.
name: Nugent, N.R.
name: Rice, J.P.
name: Farrer, L.A.
name: Miller, M.W.
name: Aiello, A.E.
name: Nievergelt, C.M.
name: Duncan, L.E.
name: Bierut, L.J.
name: Bradley, B.
name: Wildman, D.E.
name: Daly, M.J.
name: Koen, N.
name: Polimanti, R.
name: Amstadter, A.B.
name: Ressler, K.J.
name: Galea, S.
name: King, A.
name: Bisson, J.
name: Guffanti, G.
name: Sumner, J.A.
name: Kimbrel, N.A.
name: Johnson, E.O.
name: Maihofer, A.X.
name: Ripke, S.
name: Kranzler, H.R.
name: Yehuda, R.
name: Koenen, K.C.
name: Ursano, R.J.
name: Beckham, J.C.
name: Uddin, M.
name: Gelernter, J.E.
name: Liberzon, I.
name: Zhao, H.
name: Saccone, N.L.
name: Stein, M.B.
name: Martin, A.R.
name: Stein, D.J.
name: Logue, M.W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Background: The nature and underlying mechanisms of the observed increased vulnerability to posttraumatic stress disorder (PTSD) in women are unclear. Methods: We investigated the genetic overlap of PTSD with anthropometric traits and reproductive behaviors and functions in women. The analysis was conducted using female-specific summary statistics from large genome-wide association studies (GWAS) and a cohort of 3577 European American women (966 PTSD cases and 2611 trauma-exposed controls). We applied a high-resolution polygenic score approach and Mendelian randomization analysis to investigate genetic correlations and causal relationships. Results: We observed an inverse association of PTSD with genetically determined anthropometric traits related to body shape, independent of body mass index (BMI). The top association was related to BMI-adjusted waist circumference (WCadj; R = -0.079, P < 0.001, Q = 0.011). We estimated a relative decrease of 64.6% (95% confidence interval = 27.5-82.7) in the risk of PTSD per 1-SD increase in WCadj. MR-Egger regression intercept analysis showed no evidence of pleiotropic effects in this association (Ppleiotropy = 0.979). We also observed associations of genetically determined WCadj with age at first sexual intercourse and number of sexual partners (P = 0.013 and P < 0.001, respectively). Conclusions: There is a putative causal relationship between genetically determined female body shape and PTSD, which could be mediated by evolutionary mechanisms involved in human sexual behaviors.
Prevalence of Escherichia coli carriage in the oropharynx of ambulatory children and adults with and without upper respiratory symptoms
Creators: name: Foxman, B.
name: Malosh, R.E.
name: Aiello, A.E.
name: De Lastours, V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: [No abstract available]
Thermal Hall Conductivity as a Probe of Gap Structure in Multi-band Superconductors: The Case of $\rm Ba_{1-x}K_xFe_2As_2$
Creators: name: Checkelsky, J. G.
name: Thomale, R.
name: Li, Lu
name: Chen, G. F.
name: Luo, J. L.
name: Wang, N. L.
name: Ong, N. P.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: The sign and profile of the thermal Hall conductivity $κ_{xy}$ gives important insights into the gap structure of multi-band superconductors. With this perspective, we have investigated $κ_{xy}$ and the thermal conductivity $κ_{xx}$ in $\rm Ba_{1-x}K_xFe_2As_2$ which display large peak anomalies in the superconducting state. The anomalies imply that a large hole-like quasiparticle (qp) population exists below the critical temperature $T_c$. We show that the qp mean-free-path inferred from $κ_{xx}$ reproduces the observed anomaly in $κ_{xy}$, providing a consistent estimate of a large qp population. Further, we demonstrate that the hole-like signal is consistent with a theoretical scenario where despite potentially large gap variations on the electron pockets, the minimal homogeneous gap of the superconducting phase resides at a hole pocket. Implications for probing the gap structure in the broader class of pnictide superconductors are discussed.
description: 5 pages, 4 figures. Orientation significantly updated from previous (0811.4668v1) reflecting new theoretical understanding of experimental results and physical implications. Introduction, discussion, and figures updated including additional figure for model calculation
Disparities among 2009 pandemic influenza A (H1N1) hospital admissions: A mixed methods analysis - Illinois, April-December 2009
Creators: name: Sinkowitz-Cochran, R.
name: Glover, M.
name: McDonald, M.
name: Njai, R.
name: Aiello, A.E.
name: Garcia, J.
name: Schneider, A.
name: Medina-Marino, A.
name: Soyemi, K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: During late April 2009, the first cases of 2009 pandemic influenza A (H1N1) (pH1N1) in Illinois were reported. On-going, sustained local transmission resulted in an estimated 500,000 infected persons. We conducted a mixed method analysis using both quantitative (surveillance) and qualitative (interview) data; surveillance data was used to analyze demographic distribution of hospitalized cases and follow-up interview data was used to assess health seeking behavior. Invitations to participate in a telephone interview were sent to 120 randomly selected Illinois residents that were hospitalized during April-December 2009. During April-December 2009, 2,824 pH1N1 hospitalizations occurred in Illinois hospitals; median age (interquartile range) at admission was 24 (range: 6-49) years. Hospitalization rates/100,000 persons for blacks and Hispanics, regardless of age or sex were 2-3 times greater than for whites (blacks, 36/100,000 (95% Confidence Interval ([95% CI], 33-39)); Hispanics, 35/100,000 [95%CI,32-37] (; whites, 13/100,000[95%CI, 12-14); p<0.001). Mortality rates were higher for blacks (0.9/100,000; p<0.09) and Hispanics (1/100,000; p<0.04) when compared with the mortality rates for whites (0.6/ 100,000). Of 33 interview respondents, 31 (94%) stated that they had heard of pH1N1 before being hospitalized, and 24 (73%) did not believed they were at risk for pH1N1. On average, respondents reported experiencing symptoms for 2 days (range: 1-7) before seeking medical care. When asked how to prevent pH1N1 infection in the future, the most common responses were getting vaccinated and practicing hand hygiene. Blacks and Hispanics in Illinois experienced disproportionate pH1N1 hospitalization and mortality rates. Public health education and outreach efforts in preparation for future influenza pandemics should include prevention messaging focused on perception of risk, and ensure community wide access to prevention messages and practices.
EMEP model configuration file for the study "Downscaling of air pollutants in Europe using uEMEP_v6"
Creators: name: Mu, Qing
Publisher: name: Zenodo
Year: 2021

description: The configuration file of the EMEP model version rv4.36, for the study "Downscaling of air pollutants in Europe using uEMEP_v6". https://gmd.copernicus.org/preprints/gmd-2021-198/
title: Speeches by Secretary of Transportation Rodney E. Slater: June-December 1998
Creators: name: Slater, Rodney E.
name: United States Department of Transportation
Publisher: name: United States Department of Transportation
publisherIdentifier: https://ror.org/02xfw2e90
publisherIdentifierScheme: ROR
Year: 1998
Subjects: classificationCode: https://trt.trb.org/term/87904
subject: Transportation
classificationCode: https://trt.trb.org/term/89768
subject: Transportation planning
classificationCode: https://trt.trb.org/term/88891
subject: Transportation policy
classificationCode: https://trt.trb.org/term/90595
subject: Transportation safety
classificationCode: https://trt.trb.org/term/91422
subject: Economic and social factors
classificationCode: https://trt.trb.org/term/92116
subject: Federal government
classificationCode: https://trt.trb.org/term/92130
subject: Transportation departments

description: One zipped folder containing digitized PDFs. See the Secretary of Transportation Speeches Collection's finding aid at: https://ntl.as.atlas-sys.com/repositories/2/resources/4
description: Speeches by Secretary of Transportation Rodney E. Slater from June 1998 through December 1998.
Synchronous multi-decadal climate variability of the whole Pacific areas revealed in tree rings since 1567
Creators: Fang, Keyan
Cook, Edward R.
Guo, Zhengtang
Chen, Deliang
Ou, Tinghai
Zhao, Yan
Publisher: name: Columbia University
Year: 2018
Subjects: Dendrochronology
Climatic changes
Natural history
Dendroclimatology

description: Oceanic and atmospheric patterns play a crucial role in modulating climate variability from interannual to multi-decadal timescales by causing large-scale co-varying climate changes. The brevity of the existing instrumental records hinders the ability to recognize climate patterns before the industrial era, which can be alleviated using proxies. Unfortunately, proxy based reconstructions of oceanic and atmospheric modes of the past millennia often have modest agreements with each other before the instrumental period, raising questions about the robustness of the reconstructions. To ensure the stability of climate signals in proxy data through time, we first identified tree-ring datasets from distant regions containing coherent variations in Asia and North America, and then interpreted their climate information. We found that the multi-decadal covarying climate patterns of the middle and high latitudinal regions around the northern Pacific Ocean agreed quite well with the climate reconstructions of the tropical and southern Pacific areas. This indicates a synchronous variability at the multi-decadal timescale of the past 430 years for the entire Pacific Ocean. This pattern is closely linked to the dominant mode of the Pacific sea surface temperature (SST) after removing the warming trend. This Pacific multi-decadal SST variability resembles the Interdecadal Pacific Oscillation.
Temperature as a potent driver of regional forest drought stress and tree mortality
Creators: Williams, A. Park
Allen, Craig D.
Macalady, Alison K.
Griffin, D.
Woodhouse, Connie
Meko, David M.
Swetnam, Thomas W.
Rauscher, Sara A.
Seager, Richard
Grissino-Mayer, Henri D.
Dean, Jeffrey S.
Cook, Edward R.
Gangodagamage, Chandana
Cai, Michael
McDowell, Nate G.
Publisher: name: Columbia University
Year: 2012
Subjects: Forest ecology
Forest health
Forests and forestry
Droughts

description: As the climate changes, drought may reduce tree productivity and survival across many forest ecosystems; however, the relative influence of specific climate parameters on forest decline is poorly understood. We derive a forest drought-stress index (FDSI) for the southwestern United States using a comprehensive tree-ring data set representing AD 1000–2007. The FDSI is approximately equally influenced by the warm-season vapour-pressure deficit (largely controlled by temperature) and cold-season precipitation, together explaining 82% of the FDSI variability. Correspondence between the FDSI and measures of forest productivity, mortality, bark-beetle outbreak and wildfire validate the FDSI as a holistic forest-vigour indicator. If the vapour-pressure deficit continues increasing as projected by climate models, the mean forest drought-stress by the 2050s will exceed that of the most severe droughts in the past 1,000 years. Collectively, the results foreshadow twenty-first-century changes in forest structures and compositions, with transition of forests in the southwestern United States, and perhaps water-limited forests globally, towards distributions unfamiliar to modern civilization.