cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Clarithromycin ion pair in a liposomal membrane to improve its stability and reduce its irritation caused by intravenous administration
Creators: name: Geng, Sicong
name: Liu, Xiaolin
name: Xu, Hang
name: Cai, Cuifang
name: Zhang, Yu
name: Yao, Qing
name: Xu, Helin
name: Gou, Jingxin
name: Yin, Tian
name: Xiao, Wei
name: Tang, Xing
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biophysics
Biochemistry
Space Science
Physical Sciences not elsewhere classified
Cell Biology
Neuroscience
Pharmacology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Cancer
Mental Health

description: Objective: The aim of this study was to improve the drug loading (DL) and stability of clarithromycin (CLA)-loaded liposomes, and reduce the irritation caused by intravenous administration of CLA. Methods: A CLA–cholesteryl hemisuccinate (CHEMS) ion pair (CIP) was prepared by the solvent evaporation method and confirmed by fourier transform infrared spectroscopy, 1H-nuclear magnetic resonance, differential scanning calorimetry and X-ray powder diffraction. Subsequently, CIP liposomes (CIP-Lip) were prepared by the thin-film dispersion method and evaluated in terms of their size, zeta-potential, in vitro release, stability, in vitro antimicrobial activity and irritation. Results: The CIP-Lip exhibited a homogeneous round shape, and their size, ζ-potential, encapsulation efficiency (EE) and DL were 71.89 ± 2.6 nm, −9.91 ± 0.82 mV, 95.1 ± 1.5% and 7.8 ± 0.3%, respectively. The physical appearance and drug content of CIP-Lip over a three-month storage remained almost unchanged. The release of CLA in CIP-Lip was pH-dependent, with a more rapid release at pH 6.0 than at pH 7.4. Although the in vitro antimicrobial activity of CIP-Lip was comparable with free CLA, the irritation produced by CIP-Lip was significantly reduced compared with CLA solution. Conclusions: These findings suggest that CIP-Lip is a promising intravenous drug delivery system, especially on account of its high DL and reduced irritation.
Review of William Loaders Sexuality and the Jesus tradition
Creators: name: Carden, Michael
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Michael Carden reviews William Loaders Sexuality and the Jesus tradition (Grand Rapids: Eerdmans, 2005). Copyright 2006 Michael Carden. No part of this article may be reproduced by any means without the written consent of the publisher.
Review of Anders Gerdmar, Roots of Theological Anti-Semitism: German Biblical Interpretation and the Jews, from Herder and Semler to Kittel and Bultmann: (Leiden and Boston, 2009)
Creators: name: Fuchs, Esther
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: No description provided Copyright 2010 Esther Fuchs. No part of this article may be reproduced by any means without the written consent of the publisher.
Golden Oldies
Creators: name: Aichele, George
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: George Aichele reviews:Shimon Bar-Efrats Narrative Art in the Bible (Journal for the Study of the Old Testament Supplement Series; 70. London: T&T Clark International; 2004. pp. 295. ISBN0567084957). And;Philip Daviess Whose Bible Is It Anyway? (Second edition. London: T&T Clark International; 2004. pp. 159. ISBN: 0567080730). Copyright 2005 George Aichele. No part of this article may be reproduced by any means without the written consent of the publisher.
Comparative analysis of essential oil composition from flower and leaf of Magnolia kwangsiensis Figlar & Noot.
Creators: name: Zheng, Yan-Fei
name: Ren, Fan
name: Liu, Xiong-Min
name: Lai, Fang
name: Ma, Li
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: The essential oils from Magnolia kwangsiensis Figlar & Noot. were obtained using hydrodistillation, and analysed by GC and GC–MS. A total of 31, 27 and 26 constituents were identified in the oils from male flower, female flower and leaf of M. kwangsiensis, and they comprised 99.2, 98.5 and 96.2% of the oils, respectively. Monoterpene hydrocarbons predominated in the oils and accounted for 48.3% of male flower oil, 54.0% of female flower oil and 44.6% of leaf oil. The compositions of flower oils were quite similar but with different content, and were different from those of leaf oil.
Review of Ellen F. Davis, Scripture, Culture, and Agriculture: An Agrarian Reading of the Bible: (New York: Cambridge University Press, 2008)
Creators: name: Mitchell, Christine
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: No description provided Copyright 2009 Christine Mitchell. No part of this article may be reproduced by any means without the written consent of the publisher.
Review of Carolyn Osiek and Margaret Y. MacDonalds A womans place
Creators: name: Bird, Jennifer
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Jennifer Bird reviews Carolyn Osiek and Margaret Y. MacDonalds A womans place: House churches in earliest Christianity, with Janet H. Tulloch (Minneapolis: Fortress, 2006). Copyright 2006 Jennifer Bird. No part of this article may be reproduced by any means without the written consent of the publisher.
Review of J. W. Rogerson, According to the Scriptures: The Use of the Bible in Social, Moral, and Political Questions: (London: Equinox, 2007)
Creators: name: Martin, Craig
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: No description provided Copyright 2009 Craig Martin. No part of this article may be reproduced by any means without the written consent of the publisher.
Two new diacetylene glycosides: bhutkesoside A and B from the roots of Ligusticopsis wallichiana
Creators: name: Adhikari, Bibek
name: Prasad Devkota, Hari
name: Raj Joshi, Khem
name: Watanabe, Takashi
name: Yahara, Shoji
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Two new diacetylene glycosides: bhutkesoside A (1) and B (2), along with 10 known compounds, i.e. falcarindiol (3), chlorogenic acid (4), 5-O-p-coumaroyl-quinic acid (5), 3,5-di-O-caffeoyl-quinic acid (6), 4-hydroxy-7-methoxy-phenylethanol (7), ferulic acid (8), dehydrodiconiferyl alcohol-4-O-β-d-glucopyranoside (9), 5,7-dihydroxy-2-methylchromone-7-O-rutinoside (10), schumanniofioside B (11) and marmesinin (12) were isolated from the roots of Ligusticopsis wallichiana (DC) Pimenov & Kljuykov (Apiaceae), commonly known as ‘Bhutkesh’ in Nepal. The structures were determined on the basis of spectroscopic data. Compounds 4 and 6 showed potent antioxidant activity on DPPH free radical scavenging assay.
Review of Daniel Bodi, The Michal Affair
Creators: name: Miscall, Peter D
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Peter Miscall reviews The Michal Affair: From Zimri-Lim to the Rabbis by Daniel Bodi (in collaboration with Brigitte Donnet-Guez). Hebrew Bible Monographs, 3. Sheffield: Sheffield Phoenix, 2005. Copyright 2007 Peter D. Miscall. No part of this article may be reproduced by any means without the written consent of the publisher.
Review of Susan Ackermans When heroes love
Creators: name: Heacock, Anthony
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Anthony Heacock reviews Susan Ackermans When heroes love: The ambiguity of eros in the stories of Gilgasmesh and David (Columbia University Press, 2005. Gender, Theory and Religion. ISBN: 0-231-13260-3). Copyright 2006 Anthony Heacock. No part of this article may be reproduced by any means without the written consent of the publisher.
Review of Sylvie Gambaudo, Kristeva, Psychoanalysis and Culture: Subjectivity in Crisis: (Aldershot: Ashgate, 2007)
Creators: name: Jorgensen, Darren
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: No description provided Copyright 2008 Darren Jorgensen. No part of this article may be reproduced by any means without the written consent of the publisher.
Review of Kevin Harts Postmodernism: A Beginners Guide
Creators: name: Miscall, Peter D
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Peter Miscall reviews Kevin Harts Postmodernism: A Beginners Guide (Oxford: One World, 2004). Copyright 2007 Peter D. Miscall. No part of this article may be reproduced by any means without the written consent of the publisher.
Mesenchymal Stem Cells Modulate Light-induced Activation of Retinal Microglia Through CX3CL1/CX3CR1 Signaling
Creators: name: Huang, Libin
name: Xu, Guoxing
name: Guo, Jian
name: Xie, Maosong
name: Chen, Lisha
name: Xu, Wei
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Hematology

description: Purpose: To evaluate the effect of CX3CL1/CX3CR1 signaling on the interaction between mesenchymal stem cells (MSCs) and retinal microglia. Methods: Supernatants of homogenized retina were harvested from light-damaged SD rats (ISHR) to stimulated retinal microglia. Stimulated microglia were cocultured with MSCs, CX3CL1 over-expressing MSCs (CX3CL1-MSCs) or CX3CL1-blocked MSCs (anti-CX3CL1-MSCs) for 24 hours, and their molecular and functional changes were examined. Moreover, soluble CX3CL1 was directly added to microglia cultures. Results: ISHR stimulation activated retinal microglia. MSCs coculture inhibited the protein expression of pro-inflammatory factors by activated microglia, increased the protein expression of neurotrophic factors, and was accompanied with upregulation of CX3CR1. Meanwhile, MSCs suppressed proliferative and migratory function of activated microglia, but promoted the phagocytic capability. These effects were strengthened by CX3CL1- MSCs, and reversed by anti-CX3CL1-MSCs. Soluble CX3CL1 could enhanced microglial migration. Conclusions: MSCs might restore homeostatic functions of retinal microglia responded to light damage mainly through CX3CL1/CX3CR1 signaling.
Module Preservation Across Breast Cancer RNA-seq Data Using WGCNA
Creators: name: Yuanjing Ma
Publisher: name: figshare
Year: 2017
Subjects: subject: 10402 Biostatistics
subject: FOS: Mathematics

description: Breast cancer is the most common cancer in US, 61,000 new cases are expected to be diagnoised in 2016. Even though a list of differentially expressed genes and frequently mutated genes have been identified, the differential co-expression network and the module preservation between normal breast tissue and early stage in breast carcinogenesis haven’t been explored. Here, we constructed the weighted gene co-expression network and used extensive module preservation statistics to identify unique modules for normal breast tissue and stage 1 breast cancer. We identified several pathways that have been validated to be important during breast cancer development including PI3K-AKT pathway, Hippo pathway and extraceullar matrix pathway; we also found the pathway enriched in stage-specfic module is potential to inform drug repurposing. The results have demonstrated great potential in the identification of drug targets and prognostic markers.
Review of J. Cheryl Exums The Bible in Film The Bible and Film
Creators: name: Carden, Michael
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Michael Carden reviews The Bible in Film The Bible and Film, edited by J. Cheryl Exum (Leiden: Brill, 2006). Copyright 2007 Michael Carden. No part of this article may be reproduced by any means without the written consent of the publisher.
On animals: reviewing Agamben, Atterton & Calarco
Creators: name: Chrulew, Matthew
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Matthew Chrulew reviews two publications: The Open: Man and Animal, by Giorgio Agamben (Kevin Attell, translator; W. Hamacher, editor. California: Stanford University Press; 2004. MERIDIAN: Crossing Aesthetics series), and Animal Philosophy: Essential Readings in Continental Thought, edited by Matthew Calarco and Peter Atterton (London and New York: Continuum; 2004). Copyright 2005 Matthew Chrulew. No part of this article may be reproduced by any means without the written consent of the publisher.
Review of Elisabeth Schssler Fiorenza, The Power of the Word: Scripture and the Rhetoric of Empire: (Minneapolis: Fortress, 2007)
Creators: name: Bird, Jennifer
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: No description provided Copyright 2008 Jennifer Bird. No part of this article may be reproduced by any means without the written consent of the publisher.
The Story of Hannah (1 Sam 1:12:11) from a perspective of Han: the three-phase transformative process
Creators: name: Kim, Yung Suk
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: This article explores how Hannah undergoes her difficult life experience called han, and how she is being transformed beyond the logic of us or them hermeneutics. In the process of transformation Hannah engages three phases of attitude or moments of life: I am nothing, I am something, and I am anything. The story of Hannah becomes a story of public, holistic transformation that involves self, community and society. Copyright 2008 Yung Suk Kim. No part of this article may be reproduced by any means without the written consent of the publisher.
Synthesis of homochiral helical metal–organic frameworks based on lactate derivatives
Creators: name: Xu, Zhong-Xuan
name: Xiao, Yu
name: Zhang, Jian
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: A pair of homochiral metal–organic frameworks (HMOFs) based on semi-rigid 5-(1-carboxyethoxy)isophthalic acid (H3CIA), [Zn5((R)-CIA)3(OH)2(H2O)4]·NH2(CH3)2·4.5H2O (1-D) and [Zn5((S)-CIA)3(OH)2(H2O)4]·NH2(CH3)2·4.5H2O (1-L), were synthesized and structurally characterized. They are enantiomers and exhibit 3-D framework structures. In each structure, the CIA ligands link the Zn centers into a homochiral open framework with tetranuclear and trinuclear Zn-clusters. An interesting double helix built from the connectivity between CIA ligands and Zn centers is presented. The chiral nature of 1-D and 1-L was further confirmed by CD spectra. Photoluminescence of 1-D was also investigated in the solid state at room temperature.
Quantification and bio-assay of α-glucosidase inhibitors from the roots of Glycyrrhiza uralensis Fisch.
Creators: name: Gou, San-hu
name: Liu, Jie
name: He, Miao
name: Qiang, Yin
name: Ni, Jing-man
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: This work aimed to investigate the α-glucosidase inhibitor from the roots of Glycyrrhiza uralensis Fisch. Seven flavonoids were isolated, and the total content of compounds 1–7 were more than 50% in Glycyrrhiza total flavones (GTF), and the content of compound 1 and 2 was abundant in GTF. The results of the α-glucosidase inhibitory activities indicated that compounds 1–6 and GTF respectively with the IC50 values of 31.303, 30.263, 23.363, 19.528, 10.854, 26.454 and 21.641 μg/mL exhibited the more potent activity than acarbose with the IC50 values of 38.995 μg/mL. These result suggested that Glycyrrhiza flavonoids may become a valid alternative of potential basis for new hypoglycaemic and antidiabetic agents.
Specificity and selectivity of arbuscular mycorrhizal fungal polymerase chain reaction primers in soil samples by clone library analyses
Creators: name: Xiang, Dan
name: Chen, Baodong
name: Li, Huan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Ecology
subject: Cancer

description: An open question with regard to the community ecology of arbuscular mycorrhizal fungi (AMF) concerns how to best amplify AMF in the soil, which contains a large proportion of DNA from AM extra-radical mycelium and spores. However, to date, a direct comparison of AMF primers for soil samples, which would systematically assess their amplification efficiency, is still missing. In our present study, we compared and characterized four widely used primer sets targeting AMF 18S rDNA or SSU-ITS-LSU rDNA from three soil samples as follows: (1) SSUmAf/LSUmAr + SSUmCf/LSUmBr, (2) GeoA2/Geo11 + NS31/AM1, (3) AML1/AML2 + NS31/AM1 and (4) AMV4.5NF/AMDGR. These primer sets were compared in terms of the proportion of Glomeromycota detected, AMF diversity and community composition. Our data revealed that the newly combined primer set 3 was the most suitable one for amplifying AMF from soil samples. It yielded the highest AMF alpha diversity, and was very specific to Glomeromycota. Primer set 2 was unable to amplify Claroideoglomus from soil 1, which was the dominant AMF clade as proved by other three primer sets. Primer set 4 demonstrated its instability among different soil samples, since the proportion of AMF in total sequences varied from 5% to 83%. Although primer set 1 showed the highest proportion of AMF (95–100%) in the soil samples, it captured the lowest AMF diversity, and the operational taxonomic units obtained by this primer set were only 36.4% of that by primer set 4. Taken together, our data suggested that AMF diversity in soil samples could be underestimated by primer set 1, 2 and 4. Our result confirmed the important role of the choice of AMF primers for analyzing AMF communities in soil and explored the most suitable one for amplifying AMF from soil samples.
Selective cytotoxic eremophilane-type sesquiterpenes from Penicillium citreonigrum
Creators: name: Yuan, Bo
name: Zhao, Yu
name: Lee, Kuo-Hsiung
name: Yuan, Wei-Hua
name: Goto, Masuo
name: Hsieh, Kan-Yen
name: L Morris-Natschke, Susan.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Science Policy
Cancer
Information and Computing Sciences
Biological Sciences
Chemistry
Earth and Environmental Sciences
Engineering
Biochemistry

description: One new eremophilane-type sesquiterpene (1, citreopenin) was isolated from Penicillium citreonigrum (HQ738282), and the structure was elucidated by a combination of spectroscopic data interpretation and single-crystal X-ray diffraction analysis using Cu Kα radiation (CCDC 1030588). Compound 1 showed weak activity against KB-VIN (IC50 = 11.0 ± 0.156 μM), while the known compound 3 exhibited selective cytotoxicity against MDA-MB-231 triple-negative breast cancer (TNBC) (IC50 = 5.42 ± 0.167 μM).
Shaping Digital Sustainable Development in Chemical Companies
Creators: name: Keller, Wolfram
name: Bette, Nadine
Publisher: name: Institut für betriebswirtschaftliches Management im Fachbereich Chemie und Pharmazie
Year: 2020
Subjects: subject: 330 Economics

description: Both, digitalization and sustainable development are two megatrends with significant impact on the chemical industry in Germany through to 2025, according to a recent survey among 60 chemists. Digitalization is as seen a driver for sustainable development, even though there is no quantitative correlation in the importance of the two megatrends. When implementing Corporate Digital Sustainable Responsibility (CDSR) chemical companies need to find the right balance between business, technology, society, responsibility and mindset-related facets that chemical practitioners refer to when arguing in favor of digitalization being a driver for sustainability or against it.
Optimized LC–ESI-ion trap MS to determine simultaneously isocorynoxeine and its phase I and II metabolites in rats with application to pharmacokinetics and mass balance investigation
Creators: name: Wang, Wei
name: Li, Bo
name: Ping Chen, Ya
name: Hong Li, Mei
name: Hattori, Masao
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer

description: Isocorynoxeine (ICOR) is one of the bioactive oxindole alkaloids in Uncaria species. This study presents the pharmacokinetics and mass balance of ICOR in rats after oral dose of 40.0 mg/kg and intravenous dose of 4.0 mg/kg through detection of ICOR and its in vivo metabolites, using an optimized LC-MS with recoveries ranged from 94 to 104%, accuracy varied from 96 to 103%, and relative standard deviation for assay being less than 5%. ICOR reached its Cmax of 336.7 ng/mL in plasma 3 hr after oral dose. The phase I metabolites of ICOR, 11-hydroxyisocorynoxeine (M1), and 10-hydroxyisocorynoxeine (M2) were detected in rat heart, kidneys, urine, and feces; whereas, in rat liver and bile, M1, M2, along with phase II metabolites, 11-hydroxyisocorynoxeine 11-O-β-D-glucuronide, and 10-hydroxyisocorynoxeine 10-O-β-D-glucuronide were identified. ICOR (77.0%) was excreted into feces and urine after oral administration within 72 hr, 0.93% drained into bile in 8 hr, 17.9% biotransformed into M1 and M2 at a ratio of ca. 1:1, and 0.028% detected in main organs at tmax, in which brain uptake index is 3.2 ng/g. This work affords a developed and validated LC-MS for simultaneous determination of ICOR and its in vivo metabolites with improved precision and accuracy.
An Optimized LC-ESI-Ion Trap MS to Determine Simultaneously Isocorynoxeine and Its Phase I and II Metabolites in Rats with Application to Pharmacokinetics and Mass Balance Investigation
Creators: name: Wang, Wei
name: Li, Bo
name: Ping Chen, Ya
name: Hong Li, Mei
name: Hattori, Masao
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Pharmacology
subject: Physiology
subject: FOS: Biological sciences
subject: Microbiology
subject: Medicine
subject: Biochemistry

description: Isocorynoxeine (ICOR) is one of the bioactive oxindole alkaloids in Uncaria species. This study presents the pharmacokinetics and mass balance of ICOR in rats after oral dose of 40.0 mg/kg and intravenous dose of 4.0 mg/kg through detection of ICOR and its in vivo metabolites, using an optimized LC-MS with recoveries ranged from 94 to 104%, accuracy varied from 96 to 103%, and relative standard deviation for assay being less than 5%. ICOR reached its Cmax of 336.7 ng/mL in plasma 3 h after oral dose. The phase I metabolites of ICOR, 11-hydroxyisocorynoxeine (M1) and 10-hydroxyisocorynoxeine (M2), were detected in rat heart, kidneys, urine and feces, whereas in rat liver and bile M1, M2, along with phase II metabolites, 11-hydroxyisocorynoxeine 11-O-β-D-glucuronide and 10-hydroxyisocorynoxeine 10-O-β-D-glucuronide were identified. ICOR (77.0%) was excreted into feces and urine after oral administration within 72 h, 0.93% drained into bile in 8 h, 17.9% biotransformed into M1 and M2 at a ratio of ca 1:1, and 0.028% detected in main organs at tmax, in which brain uptake index is 3.2 ng/g. This work affords a developed and validated LC-MS for simultaneous determination of ICOR and its in vivo metabolites with improved precision and accuracy.Short abstract:This study presents the pharmacokinetics and mass balance of isocorynoxeine (ICOR) in rats after oral dose of 40.0 mg/kg and intravenous dose of 4.0 mg/kg, through simultaneous detection of ICOR and its metabolites in plasma, bile, excreta, and main organs, using an optimized LC-MS with recoveries ranged from 94 to 104%, accuracy varied from 96 to 103%, and relative standard deviation for assay being less than 5%. ICOR reached its Cmax of 336.7 ng/mL in plasma 3 h after oral dose, 77.0% of ICOR excreted into feces and urine within 72 h, 0.93% ICOR drained into bile in 8 h, 17.9% of ICOR biotransformed into its phase I metabolites, and 0.028% ICOR detected in main organs at tmax with brain uptake index being of 3.2 ng/g.
Trust and communication in policy networks: The politics of transparency in the food chain
Creators: name: Fuchs, Doris A.
name: Kalfagianni, Agni
Publisher: name: Universitäts- und Landesbibliothek Münster
Year: 2020
Subjects: subject: 300 Social sciences, Anthropology
subject: 320 Political science (Politics and government)

description: We explore the relevance of structural characteristics of policy networks for policy outcomes, thereby highlighting the continuing relevance of the policy network approach for policy analysis. Focusing on networks for transparency in the food chain in the Netherlands and the EU, we examine the proposition that network interactions in the form of communication and trust make a substantial difference in the estimation and explanation of transparency policy. Thereby, we identify existing obstacles to a successful transformation of the norm of transparency into appropriate political frameworks and governance mechanisms as well as potential steps for improvement. Data were gathered in structured interviews with the network actors in the Netherlands and at the EU level and are employed in a mathematical model allowing us to highlight the impact of communication and trust relationships on policy output.
The Forgotten Monarch: Franz Joseph and the July Crisis
Creators: name: Santerre, Matthieu
Publisher: name: figshare
Year: 2017
Subjects: History

description: This dissertation explores how Emperor Franz Joseph I was the key decision-maker in Austria-Hungary during the July Crisis that led to the First World War. As the key decision-maker, the arbiter between war and peace, his decision to sanction war on 23 July 1914 proved crucial. The monarch must be studied to understand how and why the Austro-Hungarian Dual Monarchy chose war in 1914.

World War I was not inevitable. We should not read history backwards. The assassinations of the Austro-Hungarian heir to the throne Archduke Franz Ferdinand, and his wife Sophie Chotek, at Sarajevo on 28 June 1914 were a crossroad, not a way station, on the road to Armageddon. The catastrophe that fell upon Europe in the summer of 1914 did not follow a well-worn path. The European apocalypse was not preordained; rather it came because decision-makers in the capitals of the old continent failed. One of the first capitals to fail was the Austro-Hungarian: Vienna.

Austria-Hungary chose to use Sarajevo. This was not a policy of revenge or an impulsive act. Cold calculated reason led the Austro-Hungarian Emperor to bring his realms to the brink of war. When the crucial moment finally came, Franz Joseph, the one man who could stop the war machine, the one man who could disperse the gathering storm, simply failed. Aware of the consequences, with a stroke of a pen, the monarch signed the declaration of war that would soon lead Europe, and the world, to unfathomable tragedy.
Two new benzolactones from the leaves of Nicotiana tabacum and their anti-tobacco mosaic virus activities
Creators: name: Shen, Qinpeng
name: Xu, Xingmeng
name: Zhang, Fengmei
name: Xiang, Nengjun
name: He, Pei
name: Si, Xiaoxi
name: Zhu, Ruizhi
name: Wang, Kunmiao
name: Liu, Zhihua
name: Liu, Chunbo
name: Miao, Mingming
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Plant Biology
subject: Virology

description: Two new benzolactones, 5-methyl-6-prenyl-isobenzofuran-1(3H)-one (1), 5-hydroxymethyl-6-prenyl-isobenzofuran-1(3H)-one (2), together with four known phenolic compounds (3–6), were isolated from the leaves of Nicotiana tabacum. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1–6 were evaluated for their anti-tobacco mosaic virus (anti-TMV) activities. The results showed that compounds 1–6 exhibited high anti-TMV activities with inhibition rates in the range of 16.9–26.2%, respectively.
A new sesquiterpenoid from Polyalthia petelotii
Creators: name: Yang, Caiqiong
name: Peng, Wei
name: Yang, Bijuan
name: Zhang, Junjie
name: Chen, Yegao
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: A new sesquiterpenoid (‒)-ethyl dihydrophaseate (1) was isolated from the stems and leaves of Polyalthia petelotii, together with two clerodane diterpenoids, 16α-hydroxycleroda-3,13(14)Z-dien-15,16-olide (2), 15-hydroxy-cis-ent-cleroda-3,13(E)-diene (3), a eudesmane sesquiterpenoid, eudesm-4(15)-ene-7α,11-diol (4), an aromatic aldehyde, vanillin (5), a bisisoquinolines alkaloid, spinosine (6) and an aporphine alkaloid, (‒)-oliveroline-β-N-oxide (7). Their structures were established by extensive spectroscopic analysis, including 2D-NMR techniques. Compounds 3, 4 and 6 were isolated from the genus Polyalthia for the first time and the others obtained originally from P. petelotii. The isolates were assessed for their cytotoxicity against five human tumour lines (HL-60, SMMC-7721, A-549, MCF-7 and SW-480), and the result showed that only 2 displayed weak inhibitory activity.
High performance corrosion resistant polyaniline/alkyd ecofriendly coatings
Creators: name: Ufana Riaz
Publisher: name: figshare
Year: 2017
Subjects: subject: 30301 Chemical Characterisation of Materials
subject: FOS: Chemical sciences
subject: Environmental Chemistry
subject: 30305 Polymerisation Mechanisms

description: The growing environmental concerns have led to the formulation of new coating strategies by employing inherently conductive polymers
(ICPs) as a key component in order to eliminate the toxic heavy metals from protective coatings. Also, the renewable resources are
given increasing priority within chemical industry and the energy community. Emphasis is therefore, being laid on the production and
processing of polymers from renewable resources which show advantages when compared with petrochemical raw materials and are
regarded as an ideal raw material. The present work reports the investigations on the corrosion-resistance performance of soya oil alkyd,containing nano polyaniline (PANI) against mild steel (MS). The corrosion-protective performance was evaluated in terms of physicomechanical
properties, corrosion rate, open circuit potential measurements (OCP) and scanning electron microscopy (SEM) studies. The
performance was compared to the reported PANI coatings.
Frequency of skeletal-related events and associated healthcare resource use and costs in US patients with multiple myeloma
Creators: name: Nash Smyth, Emily
name: Conti, Ilaria
name: E. Wooldridge, James
name: Bowman, Lee
name: Li, Li
name: Nelson, David R.
name: E. Ball, Daniel
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Molecular Biology
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy
subject: Hematology

description: Objective: A potential complication for all new multiple myeloma (MM) patients is the clinical presentation of osteolytic lesions which increase the risk for skeletal-related events (SREs). However, the contribution of SREs to the overall economic impact of MM is unclear. The impact of SREs on healthcare resource utilization (HCRU) and costs for US patients with MM was analyzed in Truven Health Marketscan Commercial Claims and Medicare Supplemental Databases. Methods: Adults diagnosed with MM between January 1, 2005 and December 31, 2010 with ≥2 claims ≥30 days apart (first claim = index date) were included. SREs included: hypercalcemia, pathologic fracture, surgery for the prevention and treatment of pathologic fractures or spinal cord compression, and radiation for bone pain. Rates of HCRU (outpatient [OP], inpatient [IP], emergency room [ER], orthopedic consultation [OC], and ancillary) and healthcare costs were compared between MM patients with and without SREs. Inverse propensity weighting was applied to adjust for potential bias. Results: Of 1028 MM patients (mean age = 67, standard deviation = 13.2), 596 patients with ≥1 SRE and 432 without SREs were assessed. HCRU rates in IP, ER, and ancillary (p < 0.01) and mean total costs of OP, IP, and ER were significantly higher (p < 0.05) for patients with vs without SREs during follow-up. HCRU rates also increased with SRE frequency (p < 0.05 in OP, IP, ER, OC, and ancillary), as did mean total healthcare costs, except for OC (p < 0.001). Limitations: A broad assessment of pharmacotherapy for the treatment of MM was not an objective of the current study. Bisphosphonate use was evaluated; however, results were descriptively focused on frequency of utilization only and were not included in the broader cost and HCRU analysis. Conclusions: Among US patients with MM, higher SRE frequency was associated with a significant trend of higher HCRU and total healthcare costs in several settings.
Frequency of skeletal-related events and associated health care resource use and costs in US patients with multiple myeloma
Creators: name: Li, Li
name: Nelson, David R.
name: Nash Smyth, Emily
name: Conti, Ilaria
name: E. Wooldridge, James
name: Bowman, Lee
name: E. Ball, Daniel
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: Science Policy
subject: Marine Biology
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Medicine

description: Objective: A potential complication for all new multiple myeloma (MM) patients is the clinical presentation of osteolytic lesions which increase the risk for skeletal-related events (SREs). However, the contribution of SREs to the overall economic impact of MM is unclear. The impact of SREs on health care resource utilization (HCRU) and costs for US patients with MM was analyzed in Truven Health Marketscan® Commercial Claims and Medicare Supplemental Databases.Methods: Adults diagnosed with MM between January 1, 2005 and December 31, 2010 with ≥2 claims ≥30 days apart (first claim=index date) were included. SREs included: hypercalcemia, pathologic fracture, surgery for the prevention and treatment of pathologic fractures or spinal cord compression, and radiation for bone pain. Rates of HCRU (outpatient [OP], inpatient [IP], emergency room [ER], orthopedic consultation [OC], and ancillary) and healthcare costs were compared between MM patients with and without SREs. Inverse propensity weighting was applied to adjust for potential bias.Results: Of 1028 MM patients (mean age 67, standard deviation 13.2), 596 patients with ≥1 SRE and 432 without SREs were assessed. HCRU rates in IP, ER, and ancillary (P<0.01) and mean total costs of OP, IP, and ER were significantly higher (P<0.05) for patients with vs. without SREs during follow-up. HCRU rates also increased with SRE frequency (P<0.05 in OP, IP, ER, OC and ancillary) as did mean total healthcare costs, except for OC (P<0.001).Limitations: A broad assessment of pharmacotherapy for the treatment of MM was not an objective of the current study. Bisphosphonate use was evaluated; however, results were descriptively focused on frequency of utilization only and were not included in the broader cost and HCRU analysis.Conclusions: Among US patients with MM, higher SRE frequency was associated with a significant trend of higher HCRU and total healthcare costs in several settings.
USE AND PHARMACEUTICAL PROPERTIES OF ROCKET (ERUCA VESICARIA) AND COMMON GOLDENROD (SOLIDAGO VIRGAUREA) PLANTS
Creators: name: Khalilova, Nigora
name: Murodova, Malika
Publisher: name: Zenodo
Year: 2025

description: This article focuses on the research of two plants—arugula (Eruca vesicaria) and European goldenrod (Solidago virgaurea)—which have been traditionally used in folk medicine and are also significant in the food industry. The study presents the results of scientific investigations into the systematics, geographic distribution, origin, and bioecology of these plant species cultivated in various regions of our country. The research also addresses important issues such as providing the population with high-quality food and medicinal plant products, and gaining a deeper understanding of their biological and agrotechnical characteristics
Autophagy is essential for ultrafine particle-induced inflammation and mucus hyperproduction in airway epithelium
Creators: name: Chen, Zhi-Hua
name: Wu, Yin-Fang
name: Wang, Ping-Li
name: Wu, Yan-Ping
name: Li, Zhou-Yang
name: Zhao, Yun
name: Zhou, Jie-Sen
name: Zhu, Chen
name: Cao, Chao
name: Mao, Yuan-Yuan
name: Xu, Feng
name: Wang, Bei-Bei
name: Cormier, Stephania A.
name: Ying, Song-Min
name: Li, Wen
name: Shen, Hua-Hao
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Environmental ultrafine particulate matter (PM) is capable of inducing airway injury, while the detailed molecular mechanisms remain largely unclear. Here, we demonstrate pivotal roles of autophagy in regulation of inflammation and mucus hyperproduction induced by PM containing environmentally persistent free radicals in human bronchial epithelial (HBE) cells and in mouse airways. PM was endocytosed by HBE cells and simultaneously triggered autophagosomes, which then engulfed the invading particles to form amphisomes and subsequent autolysosomes. Genetic blockage of autophagy markedly reduced PM-induced expression of inflammatory cytokines, e.g. IL8 and IL6, and MUC5AC in HBE cells. Mice with impaired autophagy due to knockdown of autophagy-related gene Becn1 or Lc3b displayed significantly reduced airway inflammation and mucus hyperproduction in response to PM exposure in vivo. Interference of the autophagic flux by lysosomal inhibition resulted in accumulated autophagosomes/amphisomes, and intriguingly, this process significantly aggravated the IL8 production through NFKB1, and markedly attenuated MUC5AC expression via activator protein 1. These data indicate that autophagy is required for PM-induced airway epithelial injury, and that inhibition of autophagy exerts therapeutic benefits for PM-induced airway inflammation and mucus hyperproduction, although they are differentially orchestrated by the autophagic flux.
บทปริทัศน์หนังสือ "Owning the Earth" The Transforming History of Land Ownership
Creators: name: ฐนพงศ์ ลือขจรชัย
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2017
Subjects: -

description: วารสารประวัติศาสตร์ ธรรมศาสตร์, 4, 2, 311-323
บทปริทัศน์หนังสือ "Emperor Hirohito and the Pacific War"
Creators: name: คงศักดิ์ ตรงธรรมพร
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2017
Subjects: -

description: วารสารประวัติศาสตร์ ธรรมศาสตร์, 4, 2, 325-335
A Co-operative Way Out of Exploitation: Reflections on the Manolada Strawberries Case (blog)
Creators: name: Morshed Mannan
name: Gkliati, Mariana
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: Migrants are often cast in the role of victims, as in the decision of the European Court of Human Rights in the Manolada Strawberries case. We argue that they may gain agency and institutionalise networks of solidarity by forming social cooperatives.
Software Stellarium e le occultazioni dei pianeti
Creators: name: Sparavigna, Amelia Carolina
Publisher: name: Zenodo
Year: 2020
Subjects: Archaeoastronomy
Archeoastronomia
Occultation
Occultazione
Astronomia
Stellarium

description: In precedenza si era studiata con Stellarium l'occultazione di Aldebaran da parte della Luna, osservata e riportata da Copernico nel 1497. Nel caso di questo fenomeno, la luna è all'apparenza molto più grande della stella. Vediamo ora come si comporta il software nel caso di diametri apparenti più piccoli.
New draft item
Creators: name: Morshed Mannan
name: Gkliati, Mariana
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: Migrants are often cast in the role of victims, as in the decision of the European Court of Human Rights in the Manolada Strawberries case. We argue that they may gain agency and institutionalise networks of solidarity by forming social cooperatives.
Autophagy Is Essential for Ultrafine Particle-Induced Inflammation and Mucus Hyperproduction in Airway Epithelium
Creators: name: Chen, Zhi-Hua
name: Zhao, Yun
name: Zhu, Chen
name: Cao, Chao
name: Mao, Yuan-Yuan
name: Xu, Feng
name: Wang, Bei-Bei
name: Li, Wen
name: Wu, Yin-Fang
name: Wang, Ping-Li
name: Wu, Yan-Ping
name: Li, Zhou-Yang
name: Zhou, Jie-Sen
name: A Cormier, Stephania
name: Ying, Song-Min
name: Shen, Hua-Hao
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Physiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Cell Biology
subject: Microbiology
subject: Engineering
subject: Biophysics

description: Environmental ultrafine particulate matter (PM) is capable of inducing airway injury, while the detailed molecular mechanisms remain largely unclear. Here, we demonstrate pivotal roles of autophagy in regulation of inflammation and mucus hyperproduction induced by PM containing environmentally persistent free radicals in human bronchial epithelial (HBE) cells and in mouse airways. PM was endocytosed by HBE cells and simultaneously triggered autophagosomes, which then engulfed the invading particles to form amphisomes and subsequent autolysosomes. Genetic blockage of autophagy markedly reduced PM-induced expression of inflammatory cytokines, e.g. IL8 and IL6, and MUC5AC in HBE cells. Mice with impaired autophagy due to knockdown of autophagy-related gene Becn1 or Lc3b displayed significantly reduced airway inflammation and mucus hyperproduction in response to PM exposure in vivo. Interference of the autophagic flux by lysosomal inhibition resulted in accumulated autophagosomes/amphisomes, and intriguingly, this process significantly aggravated the IL8 production through NFKB1, and markedly attenuated MUC5AC expression via activator protein 1. These data indicate that autophagy is required for PM-induced airway epithelial injury, and that inhibition of autophagy exerts therapeutic benefits for PM-induced airway inflammation and mucus hyperproduction, although they are differentially orchestrated by the autophagic flux.
4.UGC-4ra06698g (3).pdf
Creators: name: Ufana Riaz
Publisher: name: figshare
Year: 2017
Subjects: subject: 30302 Nanochemistry and Supramolecular Chemistry
subject: FOS: Chemical sciences

description: Microwave-enhanced photodegradation of dyes is one of the emerging and promising technologies for
waste water remediation. Microwaves effectively accelerate photocatalytic degradation, but only in the
presence of a suitable photocatalyst such as TiO2, ZnO and also when a microwave electrodeless lamp
(MEL) substitutes a traditional lamp as a light source. As the existing inorganic photocatalysts have been
proven to be potentially toxic to the aquatic environment, this remediation technique can be extremely
simplified if the photocatalyst can be replaced by a benign catalyst which can work under microwave
irradiation in the absence of any external light source. In the present study, an attempt is made for the
first time to degrade and mineralize Orange G (OG) dye in a laboratory microwave oven at 30 C, using
an organic catalyst, poly(1-naphthylamine) (PNA), a conjugated polymer synthesized by an enzymatic
method. PNA was characterized by relevant experimental techniques. The degradation was carried out
by exposing the OG dye solutions to microwave irradiation for different time intervals in the absence of
UV-vis radiation and TiO2. PNA as a catalyst was found to enhance the dye degradation under
microwave irradiation by almost two times as compared to its degradation under microwave irradiation
alone. 100 ppm of OG dye solution was found to degrade up to 90% in 20 min at 30 C in the presence
of PNA. The same solution revealed mineralization up to 85% in 40 min as confirmed by the total
organic content (TOC) analysis. With the help of LC-MS, seven intermediates were identified ranging
between m/z 227 and m/z 97, on the basis of which a tentative degradation pathway for the dye has
been proposed. Dye degradation in the presence of PNA as a microwave catalyst under the present
experimental setup was found to yield results better than other photocatalytic or microwave-assisted
photocatalytic degradation methods.
Worldwide Ethnographic Wooden Spears Map
Creators: name: Milks, Annemieke
Publisher: name: figshare
Year: 2020
Subjects: subject: 160104 Social and Cultural Anthropology
subject: FOS: Sociology

description: This map accompanies the dataset in this collection, Ethnography of Wooden Spears. The dataset and map support the following publication: Milks, A. 2020. A Review of Ethnographic Wooden Spears and Implications for Pleistocene Weaponry. Open Quaternary,
It is important to note that locations are very approximate. Suggested corrections and/or additions to the map are welcome.