cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
КОНСПЕКТ ФЛОРЫ СВЕРДЛОВСКОЙ ОБЛАСТИ. ЧАСТЬ V: ДВУДОЛЬНЫЕ РАСТЕНИЯ (ROSACEAE)
Creators: name: КНЯЗЕВ М.С.
name: ЧКАЛОВ А.В.
name: ТРЕТЬЯКОВА А.С.
name: ЗОЛОТАРЁВА Н.В.
name: ПОДГАЕВСКАЯ Е.Н.
name: ПАКИНА Д.В.
name: КУЛИКОВ П.В.
Publisher: name: Фиторазнообразие Восточной Европы
Year: 2019
Subjects: ФЛОРА
ДВУДОЛЬНЫЕ РАСТЕНИЯ
ROSACEAE
СВЕРДЛОВСКАЯ ОБЛАСТЬ
СРЕДНИЙ УРАЛ
FLORA
DICOTYLEDONOUS PLANTS
SVERDLOVSK REGION
MIDDLE URALS

description: Представлен подробный конспект флоры двудольных растений (сем. Rosaceae ) Свердловской области. Приведены сведения о распространении, биоэкологических особенностях и хозяйственном значении 138 видов, 1 подвида и 4 межвидовых гибридов сосудистых растений природной флоры Свердловской области, а также 20 наиболее распространенных культивируемых растений. Обозначены виды, нуждающиеся в охране на территории региона. Рассматривается история развития природоохранных идей и сети особо охраняемых природных территорий в Свердловской области.
p16 loss rescues functional decline of Brca1-deficient mammary stem cells
Creators: name: Scott, Alexandria
name: Bai, Feng
name: Chan, Ho Lam
name: Shiqin Liu
name: Slingerland, Joyce M
name: Robbins, David J.
name: Capobianco, Anthony J.
name: Pei, Xin-Hai
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Developmental Biology
subject: Cancer

description: Recent evidence indicates that the accumulation of endogenous DNA damage can induce senescence and limit the function of adult stem cells. It remains elusive whether deficiency in DNA damage repair is associated with the functional alteration of mammary stem cells. In this article, we reported that senescence was induced in mammary epithelial cells during aging along with increased expression of p16Ink4a (p16), an inhibitor of CDK4 and CKD6. Loss of p16 abrogated the age-induced senescence in mammary epithelial cells and significantly increased mammary stem cell function. We showed that loss of Brca1, a tumor suppressor that functions in DNA damage repair, in the mammary epithelium induced senescence with induction of p16 and a decline of stem cell function, which was rescued by p16 loss. These data not only answer the question as to whether deficiency in DNA damage repair is associated with the functional decline of mammary stem cells, but also identify the role of p16 in suppressing Brca1-deficient mammary stem cell function.
КОНСПЕКТ ЧУЖЕРОДНЫХ РАСТЕНИЙ СРЕДНЕГО ПОВОЛЖЬЯ
Creators: name: СЕНАТОР С.А.
name: ВАСЮКОВ В.М.
Publisher: name: Фиторазнообразие Восточной Европы
Year: 2019
Subjects: ЧУЖЕРОДНЫЕ ВИДЫ
НАТУРАЛИЗАЦИЯ
ИНВАЗИОННЫЕ ВИДЫ
СОСУДИСТЫЕ РАСТЕНИЯ
СРЕДНЕЕ ПОВОЛЖЬЕ
ALIEN SPECIES
NATURALIZATION
INVASIVE SPECIES
VASCULAR PLANTS
MIDDLE VOLGA REGION

description: Впервые публикуется список чужеродных растений, зарегистрированных на территории Среднего Поволжья (в границах Самарской и Ульяновской областей). Чужеродная флора Среднего Поволжья представлена 461 видом сосудистых растений, относящимися к 275 родам и 77 семействам (23.1% от всей флоры). Для каждого вида приводится информация о времени появления во флоре (археофит, неофит), способе заноса (ксенофит, эргазиофигофит), инвазионном статусе (эфемерофит, колонофит, эпекофит, агриофит), жизненной форме, географическом элементе, частоте встречаемости, спектре занимаемых местообитаний, а также дата первого упоминания. В составе чужеродной флоры Среднего Поволжья выявлено преобладание неофитов (394 вида, 85.5%) над археофитами (67 видов, 14.5%). Впервые приводятся сведения о находках таких видов, как Cleomespinosa , Echinacea purpurea , Grindelia squarrosa , Jovibarba globifera , Phaseolusvulgaris и Rudbeckia laciniata . Все перечисленные виды сопровождены комментариями. Среди чужеродных растений преобладают эпекофиты (149 видов, 32.3%) и эфемерофиты (148 видов, 32.1%), 142 вида относятся к колонофитам (30.8%) и 22 агриофитам (4.8%). К исчезнувшим относится 21 вид, они приведены в общем списке, но не включены в анализ. В настоящее время наблюдается высокий темп адвентизации региональной флоры 161 вид (35.0% от их общего числа) зафиксированы в последние 20 лет. По способам заноса чужеродные виды распределяются почти одинаково 227 ксенофитов (49.2%) и 234 эргазиофигофитов (50.8%). Выявлены наиболее распространенные в регионе чужеродные виды. Представлены результаты распределения чужеродных видов по типам местообитаний.
Additional file 1 of Bayesian estimation of scaled mutation rate under the coalescent: a sequential Monte Carlo approach
Creators: name: Ogundijo, Oyetunji E.
name: Wang, Xiaodong
Publisher: name: figshare
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material. (PDF 232 kb)
EUPHORBIA DAVIDII SUBILS (EUPHORBIACEAE) - НОВЫЙ ВИД ДЛЯ ЦЕНТРАЛЬНОГО ЧЕРНОЗЕМЬЯ (РОССИЯ)
Creators: name: ТОХТАРЬ В.К.
name: КУРСКОЙ А.Ю.
Publisher: name: Фиторазнообразие Восточной Европы
Year: 2019
Subjects: EUPHORBIA DAVIDII
ЧУЖЕРОДНЫЙ ВИД
КАРАНТИННЫЙ ВИД
ЦЕНТРАЛЬНОЕ ЧЕРНОЗЕМЬЕ
БЕЛГОРОДСКАЯ ОБЛАСТЬ
ALIEN SPECIES
QUARANTINE SPECIES
CENTRAL BLACK SOIL REGION
BELGOROD OBLAST

description: Сообщается о находке на территории Белгородской области (Россия) Euphorbia davidii Subils нового вида для флоры Центрального Черноземья. Общая площадь территории, занятой популяцией этого вида, составляет более 300 м2. Приводятся данные об основных диагностических различиях между близкими видами: E. davidii и E . dentata Michx. и информация о находках этого адвентивного растения в Европе и в России. В большинстве популяций E. davidii представлен небольшим числом растений, однако в ряде случаев зарегистрированы группы растений, занимающие значительные площади. Отмечено, что вид встречается, преимущественно, на железных дорогах и сельскохозяйственных угодьях и не внедряется в естественные местообитания.
МАТЕРИАЛЫ К ФЛОРЕ ЮГО-ЗАПАДА ПЕНЗЕНСКОЙ ОБЛАСТИ: БЕКОВСКИЙ И ТАМАЛИНСКИЙ РАЙОНЫ
Creators: name: ВАСЮКОВ В.М.
name: НОВИКОВА Л.А.
name: ГОРБУШИНА Т.В.
name: ИВАНОВА А.В.
name: ЛЫСЕНКО Т.М.
Publisher: name: Фиторазнообразие Восточной Европы
Year: 2019
Subjects: ФЛОРА
РЕДКИЕ ВИДЫ
КРАСНАЯ КНИГА
ПЕНЗЕНСКАЯ ОБЛАСТЬ
БЕКОВСКИЙ РАЙОН
ТАМАЛИНСКИЙ РАЙОН
FLORA
RARE SPECIES
RED BOOK
PENZA REGION
BEKOVO DISTRICT
TAMALA DISTRICT

description: В результате ботанических исследований в 2019 г. на территории Бековского и Тамалинского районов Пензенской области выявлено 620 видов сосудистых растений, в том числе 5 видов, занесенных в Красную книгу Российской Федерации (2008) Fritillaria ruthenica Wikstr., Iris aphylla L., Stipa dasyphylla (Lindem.) Czern. ex Trautv., S. pennata L. s.str., S. zalesskyi Wilensky ex Grossh. и 32 вида, занесенные в Красную книгу Пензенской области (2013). Представлены результаты флористического обследования 11 географических пунктов.
7,8-benzoflavone binding to human cytochrome P450 3A4 reveals complex fluorescence quenching, suggesting binding at multiple protein sites
Creators: name: Marsch, Glenn A.
name: Carlson, Benjamin T.
name: F. Peter Guengerich
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: Human cytochrome P450 (P450) 3A4 is involved in the metabolism of one-half of marketed drugs and shows cooperative interactions with some substrates and other ligands. The interaction between P450 3A4 and the known allosteric effector 7,8-benzoflavone (α-naphthoflavone, αNF) was characterized using steady-state fluorescence spectroscopy. The binding interaction of P450 3A4 and αNF effectively quenched the fluorescence of both the enzyme and ligand. The Hill Equation and Stern–Volmer fluorescence quenching models were used to evaluate binding of ligand to enzyme. P450 3A4 fluorescence was quenched by titration with αNF; at the relatively higher [αNF]/[P450 3A4] ratios in this experiment, two weaker quenching interactions were revealed (Kd 1.8–2.5 and 6.5 μM). A range is given for the stronger interaction since αNF quenching of P450 3A4 fluorescence changed the protein spectral profile: quenching of 315 nm emission was slightly more efficient (Kd 1.8 μM) than the quenching of protein fluorescence at 335 and 355 nm (Kd 2.5 and 2.1 μM, respectively). In the reverse titration, αNF fluorescence was quenched by P450 3A4; at the lower [αNF]/[P450 3A4] ratios here, two strong quenching interactions were revealed (Kd 0.048 and 1.0 μM). Thus, four binding interactions of αNF to P450 3A4 are suggested by this study, one of which may be newly recognized and which could affect studies of drug oxidations by this important enzyme.
СТРОЕНИЕ СОЦВЕТИЯ И РЕАЛИЗАЦИЯ СЕМЕННОЙ ПРОДУКТИВНОСТИ ALLIUM CRISTOPHII TRAUTV. В УСЛОВИЯХ МОСКОВСКОЙ ОБЛАСТИ
Creators: name: ИВАНОВА М.И.
name: БАЛЕЕВ Д.Н.
name: БУХАРОВ А.Ф.
name: КАШЛЕВА А.И.
Publisher: name: Фиторазнообразие Восточной Европы
Year: 2019
Subjects: ALLIUM CRISTOPHII TRAUTV
СЕМЕННАЯ ПРОДУКТИВНОСТЬ
МАССА 1000 СЕМЯН
КОЭФФИЦИЕНТ РЕАЛИЗАЦИИ СЕМЕННОЙ ПРОДУКТИВНОСТИ
SEED PRODUCTIVITY
MASS OF 1000 SEEDS
COEFFICIENT OF REALIZATION OF SEED PRODUCTIVITY

description: Allium cristophii Trautv. [ A. albopilosum С.H. Wright, A. bodeanum Regel; A. walteri Regel] типовой вид подсекции Cristophiana , является чрезвычайно полиморфным таксоном. Вид обладает довольно высокой семенной продуктивностью, которая изменяется в широких пределах. Изучена семенная продуктивность двух образцов, один из которых под названием A. albopilosum С.Н. Wright интродуцирован из Нидерландов, а второй A. сristophii получен из Ботанического сада Института биологии Коми НЦ УрО РАН. Возраст материнских луковиц 6-7 лет. В условиях Московской области у A. аlbopilosum и A. cristophii завязываемость плодов составила 89,2 и 88,5%, реальная семенная продуктивность 4,54 и 2,72 г на соцветие, масса 1000 семян 5,69 и 5,20 г соответственно (средние значения). Средняя осемененность A. albopilosum составила 5,54 шт./плод, при этом в нижнем ярусе отмечено формирование до 13 семян на плод, среднем 15, верхнем 11 семян на плод. Средняя осемененность A. cristophii 4,93 шт./плод, при этом в нижнем ярусе отмечено формирование до 11 семян на плод, среднем 10, верхнем 8 семян на плод.
Porsche House. La reggia di Scairolo. Nuovo Centro Porsche
Creators: name: Qovanaj, Urim
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2019

description: L’azienda AMAG di Zurigo ha deciso di realizzare il primo centro Porsche in Ticino, ampliando in questo modo il mercato anche nella Svizzera meridionale. Lo scopo del progetto è, quindi, quello di offrire ai clienti ticinesi un luogo che possa affiancarli a 360°, dall’acquisto della vettura fino al termine della sua durata di vita. La famosa casa automobilistica tedesca impone forme e materiali ben definiti. Lo showroom, ad esempio, che rappresenta il fiore all’occhiello dell’intero intervento, ha una forma semicircolare ed è realizzato mediante una striscia di 2.40 m completamente vetrata nella parte inferiore e al di sopra, in aggetto, la facciata è rivestita in Alucobond A2®.
Clique and elite: inter-organizational knowledge sharing across five star hotels in the Saudi Arabian religious tourism and hospitality industry
Creators: name: Idrees, Inaam Altayeb
Publisher: name: Zenodo
Year: 2018
Subjects: Knowledge sharing, Game theory, Grounded theory, Coopetition, Oligopoly theory, Prisoner's dilemma

description: This study focuses on knowledge sharing practices from an inter-organizational perspective in the Saudi Arabian religious tourism and hospitality industry
FINANCIAL RESOURCES PROVISION OF TREATMENT PREVENTIVE INSTITUTIONS
Creators: name: Keldiyorova, Feruza
Publisher: name: Zenodo
Year: 2024

description: In this article, we delve into the critical issue of securing adequate financial resources for treatment and preventive institutions, such as hospitals, clinics, and public health organizations. We highlight the indispensable role of financial stability in delivering quality healthcare services and implementing effective preventive measures. Through an exploration of various funding sources, including government grants, private donations, and innovative financing models, we examine the multifaceted challenges faced by these institutions in maintaining financial viability.
Evolution of the Data Quality Monitoring and Prompt Processing System in the protoDUNE-SP experiment
Creators: name: Potekhin, Maxim
Publisher: name: Zenodo
Year: 2020
Subjects: dqm
prompt processing
data quality monitoring
DUNE
neutrino
Liquid Argon

description: The DUNE Collaboration has successfully implemented and currently operates
 an experimental program based at CERN which includes a beam test and an extended
 cosmic ray run of two large-scale prototypes of the DUNE Far Detector.
 The volume of data already collected by the protoDUNE-SP (the single-phase
 Liquid Argon TPC prototype) amounts to approximately 3PB and the sustained rate
 of data sent to mass storage is of the order of O(100) MB/s. In addition to this data being
 committed to mass storage and processed in the Grid environment a small fraction of it is
 captured by the Prompt Processing System which is optimized for continuous low-latency
 calculation of the vital detector metrics and parameters as well as the output rendered as
 event display images. This system is the platform for Data Quality Monitoring in
 protoDUNE-SP and has served a crucial role starting from the commissioning of the
 apparatus and throughout its operation in 2018-2019, which continues at the time of writing.
 We present our experience in operating the system in the CERN environment, as well as
 work currently underway to make the system more scalable, resilient and to simplify system
 recovery procedures in preparation for the second run of protoDUNE-SP foreseen after
 the Long Shutdown of the LHC in the Fall of 2019.
MOESM1 of Discrimination of Radix Polygoni Multiflori from different geographical areas by UPLC-QTOF/MS combined with chemometrics
Creators: name: Tang, Jin-Fa
name: Li, Wei-Xia
name: Zhang, Fan
name: Li, Yu-Hui
name: Cao, Ying-Jie
name: Zhao, Ya
name: Li, Xue-Lin
name: Ma, Zhi-Jie
Publisher: name: figshare
Year: 2017
Subjects: Medicine
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified

description: Additional file 1. The Minimum Standards of Reporting Checklist.
title: Citizen robots
title: biopolitics, the computer, and the Vietnam period
titleType: Subtitle
Creators: name: Ryder, Mike
Publisher: name: Lancaster University
Year: 2020
Subjects: Vietnam
Biopolitics
Science Fiction
Agamben
Foucault
Deleuze
Esposito
Derrida
Drones
Vietnam War
America
Consumerism
Mass-production
Surveillance
Philip K. Dick
Robert Heinlein
Ursula Le Guin
Sam Delaney
Orson Scott Card
Ethics
Critical Theory
Robot
Computerization
Robotization
Frederik Pohl

description: The Vietnam War coincided with an intense period of technological change in the US that marked a significant turning point in the relationship between the citizen and the state. While computer technology found new and deadly uses on the field of battle, it also found its way into people’s homes, giving the state the means through which to monitor and control subjects like never before. While Michel Foucault describes Vietnam as ‘the gates of our world’, this thesis argues that Vietnam stands rather as the gates of our biopolitical world – a period in which Foucault’s original concept of biopolitics is reborn in the computer age. To this end, this thesis examines some of the early impacts and implications of the computerized biopolitical state, and the robotized human subject. It offers an exploration of the ways in which biopolitical ideas can be used alongside science fiction texts to interrogate the cultural tendencies of the USA during the Vietnam War period, stretching from the start of the war in 1955 through to the war’s end in 1975 and the shadow cast in the years that follow. In doing so, it charts how human subjects are complicit in the means of their own oppression, and the ethical implications of the blurred distinction between the human and the machine. Thus, it calls for a new cybernetic form of biopolitical insight – a techno-biopolitics – that integrates the robotic with current understandings of the human, the non-human and the animal, and how they are used as a means of discursive control.
Apprendimento rapido ed apprendimento lento. Effetti sull'esecuzione di un esercizio riguardante la capacità coordinativa del ritmo.
Creators: name: Lombardi, Andrea
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2018

description: Il presente lavoro di ricerca si è focalizzato sull'analisi dell'apprendimento rapido e l'apprendimento lento e gli effetti legati ad una notte di sonno di una classe (n = 18) di quarta elementare (SE Bellinzona) e dei suoi effetti sull'esecuzione di un esercizio riguardante la capacità coordinativa del ritmo. Per quanto riguarda l'apprendimento rapido gli allievi hanno eseguito due volte un percorso composto da dodici cerchi. Le due prove sono state intervallate da un periodo d'allenamento breve. Questa prima parte, per entrambe le variabili prese in considerazione (tempo e n° errori) non ha generato risultati significativi. L'allenamento breve non ha dunque contribuito positivamente all'apprendimento rapido. Il giorno seguente, per verificare gli effetti legati ad una notte di sonno, gli allievi sono stati testati sullo stesso percorso. In questo caso la variabile tempo ha mostrato un miglioramento significativo (in media del 15%, P < 0.05), significatività non riscontrata nella variabile n° di errori. Per quanto concerne l'apprendimento a lungo termine il gruppo classe, dopo aver svolto i primi due giorni di test, è stato separato. Un gruppo sperimentale (n = 9) ha svolto per cinque lezioni un allenamento legato al ritmo mentre un gruppo controllo (n = 9) ha svolto regolarmente le lezioni di educazione fisica. Dopo questa fase lunga d'allenamento tutti quanti gli allievi sono stati testati nuovamente sul percorso sperimentale. La variabile tempo ha mostrato una differenza significativa tra i due gruppi (mediamente del 25%, P < 0.003) mentre la variabile numero di errori non ha mostrato nessuna differenza significativa tra i due gruppi. L'allenamento lungo ha quindi contribuito in maniera positiva per quanto riguarda l'apprendimento lento. Infine è stato osservato anche il processo di transfert. Durante la fase due, oltre al percorso sperimentale, è stato proposto a tutti quanti gli allievi un percorso nuovo. Tra i due percorsi, per quanto riguarda il tempo, vi è stata differenza significativa (in media del 19%, P < 0.001) e dunque gli allievi non avrebbero, dopo una notte di sonno, trasferito il loro apprendimento. Apprendimento che è stato trasferito dopo l'allenamento lungo, nella quarta fase infatti il percorso nuovo ha generato una differenza significativa tra il gruppo sperimentale e quello controllo. Relatore: Giacomo Crivelli. Materia: Educazione fisica
Privacy of Library Records
Creators: name: Daqal, Hussin
Publisher: name: Zenodo
Year: 2020

description: Privacy is vital to create room for free speech, deliberation, and correlation. As such, library users require data privacy for their library records to facilitate the freedom of inquiry (Blanchard, 2016). In a library, users are concerned about issues such as unnecessary and sometimes uncomfortable scrutiny of their inquiries, library searches, resources chosen among other activities a user can participate in the library. Confidentiality is essential in this case.
E-books Technology
Creators: name: Daqal, Hussin
Publisher: name: Zenodo
Year: 2020

description: According to Maceviciute et al. (2017), the development of e-books has led to a significant shift in the market by increasing the capacity of libraries without requiring intensive capital injections. Libraries have transformed how they acquire and utilize resources after the advent of e-books. Maceviciute et al. (2017) also explain that e-books have changed the relationship between libraries and booksellers such that publishers now incorporate an aggregator rather than going through booksellers. An aggregator is a commercial e-book provider under a publishing company (Maceviciute et al. 2017).
Intercomparison of chemical mechanisms for air quality policy formulation and assessment under North American conditions
Creators: name: Derwent, Richard
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: The intercomparison of seven chemical mechanisms for their suitability for air quality policy formulation and assessment is described. Box modeling techniques were employed using 44 sets of background environmental conditions covering North America to constrain the chemical development of the longer lived species. The selected mechanisms were modified to enable an unbiased assessment of the adequacy of the parameterizations of photochemical ozone production from volatile organic compound (VOC) oxidation in the presence of NOx. Photochemical ozone production rates responded differently to 30% NOx and VOC reductions with the different mechanisms, despite the striking similarities between the base-case ozone production rates. The 30% reductions in NOx and VOCs also produced changes in OH. The responses in OH to 30% reductions in NOx and VOCs appeared to be more sensitive to mechanism choice, compared with the responses in the photochemical ozone production rates. Although 30% NOx reductions generally led to decreases in OH, 30% reductions in VOCs led to increases in OH, irrespective of mechanism choice and background environmental conditions. The different mechanisms therefore gave different OH responses to NOx and VOC reductions and so would give different responses in terms of changes in the fate and behavior of air toxics, acidification and eutrophication, and fine particle formation compared with others, in response to ozone control strategies. Policymakers need to understand that there are likely to be inherent differences in the responses to ozone control strategies between different mechanisms, depending on background environmental conditions and the extents of NOx and VOC reductions under consideration. Implications: The purpose of this paper is to compare predicted ozone responses to NOx and VOC reductions with seven chemical mechanisms under North American conditions. The good agreement found between the tested mechanisms should provide some support for their application in the air quality models used for policymaking.
Additional file 14: Figure S7. of Telomere heterogeneity linked to metabolism and pluripotency state revealed by simultaneous analysis of telomere length and RNA-seq in the same human embryonic stem cell
Creators: name: Wang, Hua
name: Zhang, Kunshan
name: Liu, Yifei
name: Fu, Yudong
name: Gao, Shan
name: Gong, Peng
name: Wang, Haiying
name: Zhou, Zhongcheng
name: Zeng, Ming
name: Wu, Zhenfeng
name: Sun, Yu
name: Chen, Tong
name: Li, Siguang
name: Liu, Lin
Publisher: name: figshare
Year: 2017
Subjects: subject: Space Science
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Developmental Biology
subject: Hematology

description: PluriNet score analysis of pluripotency state of human ESCs and differentiated cells. (a) Verification of PluriNet score for characterization of the pluripotency level. We validated the pluripotency score (named PluriNet score) using the single cell data of human pluripotent stem cells and differentiation cells from Thomsonâ s group [45]. PluriNet score displayed higher in undifferentiated hESCs than did differentiated cells from the same precursor cell. (b) Heat-map shows expression of PluriNet genes in all hESCs. Gene list of PluriNet was obtained from the GSEA website (Additional file 14: Table S6). The vertical color scale is shown as log(TPMâ +â 1). (PDF 4032 kb)
title: Community-based hygiene education to reduce diarrhoeal disease in rural Zaire: a prospective, longitudinal study
Creators: name: Haggerty, PA
Publisher: name: London School of Hygiene & Tropical Medicine
Year: 1991

description: A randomized, controlled trial of an educational intervention to improve personal and domestic hygiene practices and to reduce diarrhoeal morbidity was conducted in Bandundu, Zaire. Oiarrhoeal histories of 2082 weaning aged children living in 18 village clusters (sites) were obtained between October and December 1987, and structured observations of hygiene behaviours associated with food preparation, meal sharing, child feeding, child defecation, and yard cleanliness were made in 300 randomly selected sentinel families. This baseline information was used to design a non-formal educational intervention. The intervention was implemented by trained community volunteers for 6 months beginning in July 1988. A second diarrhoeal and second observational study were conducted between October and December 1988, in order to evaluate the intervention. After the intervention, children in intervened sites had an 11% lower risk of diarrhoea (p
State transition model: vorapaxar added to standard antiplatelet therapy to prevent thrombosis post myocardial infarction or peripheral artery disease
Creators: name: Du, Mark
name: Chase, Monica
name: Oguz, Mustafa
name: Davies, Glenn
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Objective: To evaluate long-term health benefits and risks of adding vorapaxar (VOR) to the standard care antiplatelet therapy (SC) of aspirin and/or clopidogrel, among a population with a recent myocardial infarction (MI) and/or peripheral artery disease (PAD). Research design and methods: In a state-transition model, patients transition between health states (event-free, recurrent MI, stroke, death), while at risk of experiencing non-transition-related revascularization and non-fatal bleeding events. Risk equations developed from the TRA 2°P-TIMI 50 trial’s patient-level data were used to predict cardiovascular (CV) outcomes over longer time horizons. Additional sources, including trials and US-based observational studies, informed the inputs for short-term CV risk, non-CV death, and health-related quality of life. Survival and quality-adjusted life-years (QALYs) were estimated over a lifetime horizon, discounted at 3% per year. Results: Within a cohort of 7361 patients with recent MI and/or PAD, VOR + SC relative to SC alone yielded 176 fewer CV events (MIs, strokes, or CV deaths), but 27 more major bleeding events. VOR + SC was associated with increased life expectancy and health benefits (19.93 undiscounted life-years [LYs], 9.57 discounted QALYs vs. 19.61 undiscounted LYs, 9.41 discounted QALYs). The results were most sensitive to scenarios varying time of vorapaxar initiation, and the assumptions in the 90 day period post-MI. Additional analyses showed that add-on vorapaxar provides consistent incremental benefits in high-risk subgroups. Conclusion: This study contributes to the growing literature on secondary prevention add-on therapy, as results from these modeling analyses suggest that adding vorapaxar to SC for patients at high atherothrombotic risk can provide long-term health benefits.
Additional file 16: Figure S8. of Telomere heterogeneity linked to metabolism and pluripotency state revealed by simultaneous analysis of telomere length and RNA-seq in the same human embryonic stem cell
Creators: name: Wang, Hua
name: Zhang, Kunshan
name: Liu, Yifei
name: Fu, Yudong
name: Gao, Shan
name: Gong, Peng
name: Wang, Haiying
name: Zhou, Zhongcheng
name: Zeng, Ming
name: Wu, Zhenfeng
name: Sun, Yu
name: Chen, Tong
name: Li, Siguang
name: Liu, Lin
Publisher: name: figshare
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Heat-map showing expression of marker genes for human naïve ESCs. Of the 12 selected genes related to pluripotency, genes for naïve pluripotency, NANOG, KLF2, KLF4, TBX3, DPPA3 (STELLA), DPPA5, PRDM14, ESRRB, and REX1 are expressed at high levels in human naïve ESCs, whereas OTX2, ZIC2, ZIC3, and FGF5 decreased in human naïve ESCs. The vertical color scale is shown as log(TPM + 1). (PDF 1132 kb)
title: OFROM: interview avec ilcf21a28
Creators: name: Delafontaine, François
name: Mbembe, Pitchou
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.c1deofpl.v2#b70ad2c746b3c23cc8e807ec73bef6ed58cf52ba
Knowledge and Skills for Library and Information Science
Creators: name: Daqal, Hussin
Publisher: name: Zenodo
Year: 2021
Subjects: LIS, Master in Library Information Science, Generic Skills, and disciplinespecific skills

description: This paper is a systematic literature review of LIS professionals' knowledge and competence for the library to maintain its relevance in the existing digital world. The library has experienced many changes attributed to technology, and as a result, the skills and knowledge that employers require from LIS professionals have changed. Indeed, literature has revealed that employers are looking for a range of skills, grouped into three main categories; generic skills, personals skills, and discipline-specific skills.
title: Kin and peer contexts and militant involvement
title: a narrative analysis
titleType: Subtitle
Creators: name: Copeland, Simon
Publisher: name: Lancaster University
Year: 2020

description: The importance of kin and peer networks in facilitating recruitment is taken for granted in existing scholarship on militant groups. Largely focused on plotting the composition of such networks, much of this work leaves a number of assumptions about the influence of these relationships unchallenged and fails to consider their impact over the entirety of individuals’ engagement in militancy. An exclusion of the voices of militants themselves also contributes to a tendency for ‘kin’ to refer only to connections underpinned by genetic ties – or links that whilst objectively measurable are nevertheless only constitutive of a narrow reading of kinship. This thesis takes an alternative approach, viewing kin and peers through the lens of contemporary anthropological understandings of ‘relatedness’, or simply how individuals create similarity between themselves and others, to explore the influence of these relationships in a more nuanced manner. To do so, a new framework for systematically applying narrative analysis to a dataset of militant autobiographies published between 1945 and 2015 is developed and employed to understand how these authors draw upon kin and peers in constructing their narrative storyworlds. In doing so, this thesis argues that the complex means by which militants constitute their kinship and the role of peer networks in shaping their personally held meanings are as significant as the practical openings these relationships provide in terms of understanding individuals’ participation, continued involvement and desistence from violence. At the same time, it also contributes valuable methodological innovations for the study of the self-accounts of those involved in political violence.
title: Mathieu Brancourt, "Allègement thérapeutique : la "juste posologie" protégée par un brevet"
Creators: name: Brancourt, Mathieu
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Extrait de Remaides, no 92, été 2015. 1 fichier (33 pages).
Molecular Binding Mechanism of 5-hydroxy-1-methylpiperidin-2-one with Human Serum Albumin
Creators: name: Sangilimuthu Alagar Yadav
name: Yeggoni, Daniel Pushparaju
name: Elsinraju Devadasu
name: Rajagopal Subramanyam
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Cancer
subject: Hematology
subject: Computational Biology

description: Molecular Binding Mechanism of 5-hydroxy-1-methylpiperidin-2-one with Human Serum Albumin
Towards Reliable LLM-based Software Development Tools
Creators: name: Liu, Yue
Publisher: name: Monash University
Year: 2024
Subjects: classificationCode: 460406
subject: Software and application security

description: This thesis examines the reliability of large language models (LLMs) in software development tools. It reveals significant biases in datasets used to train these models, leading to inflated performance metrics. The research also assesses the quality of code generated by ChatGPT, identifying various issues and exploring its self-repairing abilities. Additionally, the study uncovers security flaws in Visual Studio Code extensions that use LLMs, highlighting potential risks of credential-related data leakage. Overall, the thesis provides crucial insights into the challenges of using LLMs in software development and offers recommendations for improving their reliability to enhance developer productivity and software quality.
title: The development of the enzyme linked immunosorbent assay (Elisa) for schistosomiasis and its epidemiological applications
Creators: name: McLaren, ML
Publisher: name: London School of Hygiene & Tropical Medicine
Year: 1979

description: The use of immunodiagnostic techniques for studying epidemiological aspects of schistosomiasis have been of limited value in the past owing to the type of techniques adopted and the vide cross reactivity exhibited by antigens used in the tests. In this study a relatively new technique, the Enzyme Linked Immunosorbent Assay (ELISA) was used. After the development of a standardised procedure it was applied to a wide range of S. mansoni infections representative of different epidemiological situations. A number of modifications in the basic enzyme assay technique were introduced and their merits discussed. Those which proved to be of value were a) the use of ultracentrifuged antigens, b) the development of a method for the determination of the optimum value for the reference serum endpoint, c) the use of serum eluted from filter paper blood spots, d) the use of precoated antigen plates prepared by air or vacuum drying and e) the development of quality control procedures. In evaluating the diagnostic performance in human schistosomiasis ELISA was compared with conventional immunodiagnostic techniques such as skin tests, complement fixation tests (CFT), indirect fluorescent antibody tests (IEAT) and a recently developed radioimmunoassay (RIA)incorporating a species specific egg antigen. Sera from E. Africa and the West Indies were used to assess the test in relation to important diagnostic criteria. The ELISA using soluble egg antigen exhibited higher levels of sensitivity and specificity compared to skin teats, CIT and IPAT with sera from schistosome endemic and controls from non-endemic areas. Unlike the RIA however cross reactions occurred with heterologous schistosome infections and the test did not show the same degree of association with intensity of infection and responsiveness to chemotherapy. In two large control programmes, in the Gezira region of the Sudan where S. amsoni is hyperendemic, and St. Lucia where prevalence is low, an evaluation of the diagnostic reliability of the test and the relevance of antibody measurements was made in two widely different epidemiological situations. The relative merits of a serological as compared with a conventional parasitological approach in epidemiology were examined with particular emphasis on the use of serodiagnosis for measuring incidence rates and as a primary screen for the selective removal of uninfected individuals in a prevalence survey and prior to chemotherapy.
Hypervalent Iodine(III) Chemistry: Facts, Myths and Discoveries
Creators: name: Tania, Tania
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 34
subject: Chemical sciences
subject: FOS: Chemical sciences

description: A thesis submitted in total fulfillment of the requirements for the degree of Doctor of Philosophy to the School of Agriculture, Biomedicine and Environment, La Trobe University, Victoria, Australia.
title: OFROM: interview avec ilcf21a27
Creators: name: Delafontaine, François
name: Maillard, Sandy
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.96a315p2.v2#1022b3c6ee8de0a12e99869bda2f3e84bb2c94ec
Preparation and Performance of a P–N Containing Intumescent Flame Retardant Based on Hydrolyzed Starch
Creators: name: Qu, Hao
name: Ruilan Fan
name: Jianli Yuan
name: Bingbing Liu
name: Lijie Sun
name: Rongkai Tian
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified

description: Halogen-free flame retardant is receiving an increased attention recently due to its hypotoxicity and high efficiency. Intumescent flame retardant is a hot spot in research of the halogen-free flame retardant. In this work, a P–N containing intumescent flame retardant named hydrolyzed starch phosphamide from melamine was synthesized via hydrolysis of starch, phosphorylation of the starch with phosphorus oxychloride, and the reaction between the phosphorylated starch and melamine. PU/hydrolyzed starch phosphamide from melamine composites was prepared using different additive amounts of hydrolyzed starch phosphamide from melamine. Fourier transform infrared, scanning electron microscopy, and thermogravimetric analysis were used to characterize the structures and thermal stabilities of related compounds. Flame retardation performance of hydrolyzed starch phosphamide from melamine was investigated by UL94, limit oxygen index test, and cone calorimetry. Result shows that the PU/hydrolyzed starch phosphamide from melamine composites with 30.0 php of hydrolyzed starch phosphamide from melamine got a limit oxygen index of 29.0 and UL94-V0 ranking. Heat release rate, rate of smoke release, and total smoke release were decreased distinctly.
Characterisation of a Parasitic Bacterium with Lytic Capabilities on Streptococcus sp.
Creators: name: Martins, Jarrod
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 310702
subject: Infectious agents
classificationCode: 320702
subject: Medical infection agents (incl. prions)
classificationCode: 320701
subject: Medical bacteriology
classificationCode: 310706
subject: Virology

description: Submitted in total fulfilment of the degree of Master of Science to the School of Agriculture, Biomedicine and Environment, La Trobe University, Victoria, Australia.
The use of Grounded Theory in PhD research in knowledge management A model four-stage research design
Creators: name: Idrees, Inaam Altayeb
Publisher: name: Zenodo
Year: 2011

description: Purpose – New PhD researchers sometimes face challenges when attempting to follow Grounded Theory principles to conduct their studies. These challenges may lead them to change its features or even prevent them from using the approach at all. This paper seeks to argue that, although challenging to implement, Grounded Theory is congruent with the nature of PhD research. It aims to provide an example of the application of Grounded Theory in a typically time-limited PhD research project without the need to change any of its key features and principles. Design/methodology/approach – The paper presents and discusses the research design adopted in ongoing PhD research which integrates the main guiding principles of Grounded Theory in a simplified four-stage model of theory development. Findings – The proposed model four-stage research design includes: an uncertainty stage, where the primary focus is formed; an emergence stage, where the core categories, which are the foundations of the theory, emerge; an ambiguity resolution stage, where the grey areas in the emerging theory are clarified; and a maturity stage, when relationships between categories are defined and the theory is refined. Originality/value – This research design can help new PhD researchers unfamiliar with Grounded Theory to develop a clear understanding of the process by simplifying and clarifying its main guiding principles, as well as guiding them to a clear, phased approach that takes into account the iterative and non-linear nature of this methodology. It also places boundaries on the issues that should be dealt with within each of the phases of research adopting this methodology.
Edificio residenziale con struttura in legno
Creators: name: Bottoglia, Gianluca
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2019

description: L’obbiettivo della tesi è quello di dimensionare la struttura portante dell’edificio. Esso si trova a Ligornetto, nel comune di Mendrisio, e presenta tre piani fuori terra in legno, adibiti ad appartamenti, mentre il piano interrato in calcestruzzo armato che funge da autorimessa. La struttura portante fuori terra è realizzata interamente mediante pannelli XLAM, i quali hanno lo scopo di riprendere sia le forze verticali che quelle orizzontali. Attraverso l’impiego dei pannelli XLAM come elementi di superficie, si ottengono spessori minori rispetto alle solette intelaiate, ottenendo pannelli di 120 mm in parete e 220 mm in soletta.
Additional file 1: Figure S1. of Telomere heterogeneity linked to metabolism and pluripotency state revealed by simultaneous analysis of telomere length and RNA-seq in the same human embryonic stem cell
Creators: name: Wang, Hua
name: Zhang, Kunshan
name: Liu, Yifei
name: Fu, Yudong
name: Gao, Shan
name: Gong, Peng
name: Wang, Haiying
name: Zhou, Zhongcheng
name: Zeng, Ming
name: Wu, Zhenfeng
name: Sun, Yu
name: Chen, Tong
name: Li, Siguang
name: Liu, Lin
Publisher: name: figshare
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Developmental Biology
subject: Hematology

description: Measurement of relative telomere length in single cells by scT&R-seq of various human cell lines and validation by other established methods. To validate the feasibility of this method, we analyzed the telomere length and gene expression of six single cultured osteosarcoma cells (U2OS, ALT pathway), and six single human ESCs (WA26, telomerase activity-positive). (a) Mean Ct value of single human cell after preamplification by telomere and Alu primers in WA26 and U2OS. Both Ct value of Tel and Alu of negative controls are much greater than those of single cells. (b) Standard curves used for calculation of relative telomere length by scT&R-seq. Standard curves of telomeres and Alu using human embryonic fibroblasts (HEF) show remarkable linear correlation from DNA concentrations 0.2 ng to 125 ng, indicating a high amplification efficiency of telomeres and Alu. (c) Mean Ct value of GAPDH from the same cell by scT&R-seq and value of GAPDH does not differ in these cells. OCT4/POU5F1 is highly expressed in hESC but not in U2OS, so WA26 has a low Ct value for POU5F1. (d) Comparison of telomere length by the method without separation step and scT&R-seq method. (e) Relative telomere length of individual cells from human ESC WA26 and RuES2, human cancer cells U2OS, HCT116 and HeLa, and HEF. (f) Telomere length measurement by scT&R-seq. (g) Telomere length measurement by qPCR (T/S ratio). (h) Measurement of telomere length by southern blot of terminal restriction fragments (TRF). (i) Immunofluorescence images of OCT4/POU5F1 protein expression level in WA26 and HEF cells. Scale bar = 50 μm. (j) TRAP assay of telomerase activity in hESC (WA26) and U2OS. IC, internal control; HI, heat-inactivated; NT, not treated. All values indicate mean ± SD from three independent experiments. (PDF 888 kb)
Impianto per il trattamento delle acque meteoriche autostradali Grancia
Creators: name: Dick, Fabio
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2021

description: Una delle sfide progettuali è stata la progettazione di un impianto SABA in uno spazio ridotto. Si è deciso di ipotizzare 5 nuovi impianti di piccole-medie dimensioni a ridosso dell’autostrada lungo l’intera tratta di 3km di autostrada all’altezza di Grancia. Per evitare d’intaccare il paesaggio circostante l’impianto è stato interrato ad una profondità di scavo è di 7m nella zona che confina da un lato con la strada cantonale e dall’altro con un riparo fonico di cui non si conosce l’esatta posizione della fondazione. Ad aumentare ulteriormente la difficoltà di esecuzione è la presenza di una falda acquifera ad una profondità di 4.4m.