title: ÐÐ°ÑÐ³Ð°Ð½ÐµÑ-Ð¸Ð½Ð´ÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐµ Ð°ÑÑÐµÐºÑÐ¸Ð²Ð½ÑÐµ ÑÐ°ÑÑÑÑÐ¾Ð¹ÑÑÐ²Ð° Ñ ÐºÑÑÑ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Manganese-induced affective disorders in rats
Creators: name: ÐÑÐ´ÑÐ¸Ð½ÑÐºÐ°Ñ, ÐÐ°Ð»ÐµÐ½ÑÐ¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: Ð¼Ð°ÑÐ³Ð°Ð½ÐµÑ
Ð¼Ð°ÑÐ³Ð°Ð½ÑÐµÐ²Ð°Ñ ÑÐ½ÑÐµÑÐ°Ð»Ð¾Ð¿Ð°ÑÐ¸Ñ
ÑÐµÑÐ¾ÑÐ¾Ð½Ð¸Ð½
Ð°ÑÑÐµÐºÑÐ¸Ð²Ð½ÑÐµ ÑÐ°ÑÑÑÑÐ¾Ð¹ÑÑÐ²Ð°
Ð´ÐµÐ¿ÑÐµÑÑÐ¸Ñ
ÑÑÐµÐ²Ð¾Ð¶Ð½Ð¾ÑÑÑ
manganese
manganism
serotonin
affective disorders
depression
anxiety

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description: The WHO estimates that approximately 5% of the global population experiences depression, which is attributed to an imbalance in neurotransmitters, in part due to adverse environmental factors. The inhalation of vapours containing manganese compounds, which are released into the atmosphere as a result of anthropogenic exposure, may potentially lead to the development of affective disorders. One potential reason for the development of these disorders may be manganese-induced damage to the serotoninergic system. However, there is a paucity of literature devoted to the study of the mechanisms by which elevated levels of manganese and its compounds exert influence on the serotoninergic system of the CNS. Consequently, the study of these mechanisms underlying the development of affective disorders represents a significant biomedical undertaking. The objective of this study was to assess the impact of chronic intranasal administration of manganese chloride on the development of affective disorders in rats. The results of this study demonstrated that animals administered manganese chloride solution exhibited increased anxiety and depressive-like behaviour. In response to chronic manganese intoxication, the brain of experimental animals exhibits multidirectional changes in the levels of serotonin and its metabolite 5-HIAA. These changes may be associated with impaired expression of metabolic enzymes of the serotoninergic system.