cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Chemical abundances in Galactic planetary nebulae with Spitzer spectra
Creators: name: Garcia-Hernandez, D. A.
name: Gorny, S. K.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present new low-resolution (R~800) optical spectra of 22 Galactic PNe with Spitzer spectra. These data are combined with recent optical spectroscopic data available in the literature to construct representative samples of compact (and presumably young) Galactic disc and bulge PNe with Spitzer spectra. Attending to the nature of the dust features seen in their Spitzer spectra, Galactic disc and bulge PNe are classified according to four major dust types (oxygen chemistry or OC, carbon chemistry or CC, double chemistry or DC, featureless or F) and subtypes (amorphous and crystalline, and aliphatic and aromatic). Nebular gas abundances of He, N, O, Ne, S, Cl, and Ar, as well as plasma parameters (e.g. Ne, Te) are homogeneously derived and we study the median chemical abundances and nebular properties in Galactic disc and bulge PNe depending on their Spitzer dust types and subtypes. A comparison of the derived median abundance patterns with AGB nucleosynthesis predictions show mainly that i) DC PNe, both with amorphous and crystalline silicates, display high-metallicity (solar/supra-solar) and the highest He abundances and N/O ratios, suggesting relatively massive (~3-5 M_sun) hot bottom burning AGB stars as progenitors; ii) PNe with O-rich and C-rich unevolved dust (amorphous and aliphatic) seem to evolve from subsolar metallicity (z~0.008) and lower mass (<3 M_sun) AGB stars; iii) a few O-rich PNe and a significant fraction of C-rich PNe with more evolved dust (crystalline and aromatic, respectively) display chemical abundances similar to DC PNe, suggesting that they are related objects. A comparison of the derived nebular properties with predictions from models combining the theoretical central star evolution with a simple nebular model is also presented. Finally, a possible link between the Spitzer dust properties, chemical abundances, and evolutionary status is discussed.
description: Accepted for publication in Astronomy & Astrophysics (45 pages, 17 figures, and 14 tables); final version (language corrected)
Project RESTART (Restorative, Effective Solutions Toward Accountability, Responsibility and Treatment) Evaluation Planning Project
Creators: name: Weissman, Deborah
name: Campbell, Julia
name: Moracco, Kathryn Elizabeth
name: Carman, Danielle
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Social and Behavioral Sciences
subject: Policy Design, Analysis, and Evaluation
subject: Law
subject: FOS: Law
subject: Public Health
subject: Public Affairs, Public Policy and Public Administration
subject: Law and Gender
subject: Medicine and Health Sciences

description: This project seeks to identify measurement tools currently being used to measure existing Domestic Violence Intervention Programs (DVIPs), identify exemplary program components and recommend innovative programming, and identify and develop measurement tools to be used as programs innovate.We will use quantitative and qualitative methods to identify program components and to identify and develop measures and assessment tools. Our formative work over the past two years provides a solid foundation for the current evaluation planning grant project, and will enable our team to rapidly launch measurement development for Project RESTART, which we will conduct in three phases that correspond to well-established steps for instrument development: concept identification; item construction (Phases 1-2); validity testing (Phase 3); and reliability testing (Phase 3, time and resources permitting).
Two-body orbit expansion due to time-dependent relative acceleration rate of the cosmological scale factor
Creators: name: Iorio, Lorenzo
Publisher: name: arXiv
Year: 2013
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: By phenomenologically assuming a slow temporal variation of the percent acceleration rate $\ddot S S^{-1}$ of the cosmic scale factor $S(t)$, it is shown that the orbit of a local binary undergoes a secular expansion. To first order in the power expansion of $\ddot S S^{-1}$ around the present epoch $t_0$, a non-vanishing shift per orbit $\left\langleΔr\right\rangle$ of the two-body relative distance $r$ occurs for eccentric trajectories. A general relativistic expression, which turns out to be cubic in the Hubble parameter $H_0$ at the present epoch, is explicitly calculated for it in the case of matter-dominated epochs with Dark Energy. For a highly eccentric Oort comet orbit with period $P_{\rm b}\approx 31$ Myr, the general relativistic distance shift per orbit turns out to be of the order of $\left\langleΔr\right\rangle\approx 70$ km. For the Large Magellanic Cloud, assumed on a bound elliptic orbit around the Milky Way, the shift per orbit is of the order of $\left\langleΔr\right\rangle\approx 2-4$ pc. Our result has a general validity since it holds in any cosmological model admitting the Hubble law and a slowly varying $\ddot S S^{-1}(t)$. More generally, it is valid for an arbitrary Hooke-like extra-acceleration whose \virg{elastic} parameter $\mathcal{K}$ is slowly time-dependent, irrespectively of the physical mechanism which may lead to it. The coefficient $\mathcal{K}_1$ of the first-order term of the power expansion of $\mathcal{K}(t)$ can be preliminarily constrained in a model-independent way down to a $\mathcal{K}_1\lesssim 2\times 10^{-13}$ yr$^{-3}$ level from latest Solar System's planetary observations. The radial velocities of the double lined spectroscopic binary $α$ Cen AB yield $\mathcal{K}_1\lesssim 10^{-8}$ yr$^{-3}$.
description: LaTex2e, 9 pages, no figures, no tables, 28 references. Accepted for publication in Galaxies. Typos fixed
Experimental Passive Decoy-State Quantum Key Distribution
Creators: name: Sun, Qi-Chao
name: Wang, Wei-Long
name: Liu, Yang
name: Zhou, Fei
name: Pelc, Jason S.
name: Fejer, M. M.
name: Peng, Cheng-Zhi
name: Chen, Xian-Feng
name: Ma, Xiongfeng
name: Zhang, Qiang
name: Pan, Jian-Wei
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The decoy-state method is widely used in practical quantum key distribution systems to replace ideal single photon sources with realistic light sources by varying intensities. Instead of active modulation, the passive decoy-state method employs built-in decoy states in a parametric down-conversion photon source, which can decrease the side channel information leakage in decoy state preparation and hence increase the security. By employing low dark count up-conversion single photon detectors, we have experimentally demonstrated the passive decoy-state method over a 50-km-long optical fiber and have obtained a key rate of about 100 bit/s. Our result suggests that the passive decoy-state source is a practical candidate for future quantum communication implementation.
description: 14 pages, 5 figures
title: Oxycodone Ingestion Patterns in Acute Fracture Pain: a Pilot Study Using a Digital Pill
Creators: name: Innes, Brendan J.
name: Chai, Peter R.
name: Carreiro, Stephanie
name: Chapman, Brittany
name: Griswold, Matthew
name: Boyer, Edward W.
Publisher: name: eScholarship@UMMS
Year: 2017

description: Background: Opioids are prescribed for acute pain as needed, but no data exists on how patients take opioids after discharge from the ED. This places the onus of dosing on the patient and contributes to variable prescribing by ED physicians. ED opioid prescriptions serve as a source for unintentional exposure and contribute to the opioid epidemic. We deployed a digital pill to measure opioid ingestion patterns in individuals discharged after acute fractures.

Methods: This pilot study involved individuals without chronic opioid use (i.e. prescribed opioids > 1 week) who were discharged from the ED following acute fracture. Participants were trained to use a digital pill system comprising a single pill (5 mg oxycodone tablet + radiofrequency emitter) and a hip mounted receiver. Upon contact with gastric contents, the digital pill transmitted a radio signal to the receiver, which relayed time of ingestion via cellular 3G signal in real-time to a cloud based server. Participants were instructed to take 1-2 oxycodone digital pills as needed every 8 hours for pain. Participants returned unused medication at orthopedic follow up or 1 week post discharge where any discrepancies between digital pill data and pill counts were reconciled.

Results: We enrolled 10 participants (mean age 42). 50% of fractures were managed operatively and 50% were managed nonoperatively. The system recorded ingestions with 85% accuracy. Participants ingested a mean 43 mg oxycodone during the 1 week study period with dose de-escalation occurring after 24 hours. Participants ingested a mean 75.8% of their 1 week total dose in the first 72 hours. 40% of participants stopped taking opioids by 96 hours. 40% of participants remained on opioids 1 week after injury; all required operative treatment.

Conclusions: This is the first study to determine opioid ingestion patterns in ED patients discharged with acute fracture pain. Participants self-tapered opioids after 24 hours, most ingestion occurred in the first 72 hours, and a substantial proportion (40%) stopped ingesting oxycodone by 96 hours. Our data shows individuals may require less opioid analgesics than previously considered for acute fracture pain. Additional studies should address ingestion patterns in other painful conditions and development of ED-based interventions to minimize outpatient opioid use while controlling pain.
Experimental observation of a transition from amplitude to oscillation death in coupled oscillators
Creators: name: Banerjee, Tanmoy
name: Ghosh, Debarati
Publisher: name: arXiv
Year: 2014
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: We report the first experimental evidence of an important transition scenario, namely the transition from amplitude death (AD) to oscillation death (OD) state in coupled limit cycle oscillators. We consider two Van der Pol oscillators coupled through mean-field diffusion and show that this system exhibits a transition from AD to OD, which was earlier shown for Stuart-Landau oscillators under the same coupling scheme [T. Banerjee and D. Ghosh, arXiv:1403.2907, 2014]. We show that the AD-OD transition is governed by the density of mean-field and beyond a critical value this transition is destroyed; further, we show the existence of a nontrivial AD state that coexists with OD. Next, we implement the system in an electronic circuit and experimentally confirm the transition from AD to OD state. We further characterize the experimental parameter zone where this transition occurs. The present study may stimulate the search for the practical systems where this important transition scenario can be observed experimentally.
description: 5 pages, 4 figures, Accepted version in Physical Review E
title: Health Applications of Network Science and Computational Social Science
Creators: name: Kitts, James A.
Publisher: name: eScholarship@UMMS
Year: 2017

description: Social network analysis has proliferated rapidly across the social and behavioral sciences, with increasingly apparent implications for human health. Shifting our focus from individuals to the patterns of social ties that connect them has enriched our understanding of a great variety of health-related phenomena, including the spread of STDs on contact networks, the spread of health care practices on practitioners’ professional networks, the dynamics of patient transfers on networks of clinics, and the spread of health behaviors on adolescent friendship networks. The advent of computational social science has augmented such contributions by introducing scalable methods of automatically monitoring and rigorously modeling these phenomena. Sample applications include analysis of electronic health records and other time-stamped communication traces among health care practitioners; streams of behavioral and biometric data from wearable sensors, location-aware devices, or electronic calendars; automated analysis of text in documents using natural language processing; and mapping networks of scientific collaboration by citations and co-authorships in clinical research literatures. Whereas much work in computational social science has offered new ways of empirically monitoring health behavior and health care behavior, a further contribution has been to directly model these social processes using system dynamics, microsimulation, discrete event simulation, and agent-based models. These approaches allow for computational ‘virtual’ experiments that assist in predicting, interpreting, and evaluating outcomes from health interventions. This poster will highlight some of my recent and pending work in this broad domain, aiming to identify potential collaborators in UMCCTS for projects that involve social networks or computational social science.
Cutting Roadside Trees
Publisher: name: Online Ethics Center
Year: 2006
Subjects: Community Relations
Environmental Justice
Ethics and Society
Public Well-being
Research and Practice
Risk
Safety
Social Responsibility
Sustainability
Workplace Ethics

description: For each of the past 7 years at least one person has suffered a fatal automobile accident by crashing into trees closely aligned along a 3 mile stretch of Forest Drive. Many other accidents have also occurred, causing serious injuries, wrecked cars, and damaged trees. Some of the trees are quite close to the pavement. Two law suits have been filed against the road commission for not maintaining sufficient road safety along this 3 three mile stretch. Both were dismissed because the drivers were going well in excess of the 45 mph speed limit.
Subleading corrections to the Double Coset Ansatz preserve integrability
Creators: name: Koch, Robert de Mello
name: Graham, Stuart
name: Mabanga, Wandile
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this article we compute the anomalous dimensions for a class of operators, belonging to the SU(3) sector of the theory, that have a bare dimension of order N. For these operators the large N limit and the planar limit are distinct and summing only the planar diagrams will not capture the large N dynamics. Although the spectrum of anomalous dimensions has been computed for this class of operators, previous studies have neglected certain terms which were argued to be small. After dropping these terms diagonalizing the dilatation operator reduces to diagonalizing a set of decoupled oscillators. In this article we explicitly compute the terms which were neglected previously and show that diagonalizing the dilatation operator still reduces to diagonalizing a set of decoupled oscillators.
description: 1 + 39 pages; v2: references added
US Parts
Publisher: name: Online Ethics Center
Year: 2006
Subjects: Employer/Employee Relationships
Engineer/Client Relationships
Research and Practice
Workplace Ethics

description: John Budinski, quality control engineer at Clarke Engineering, has a problem. Clarke contracted with USAWAY to supply a product subject to the requirement that all parts are made in the United States. Although the original design clearly specifies that all parts must satisfy this requirement, one of Clarke's suppliers failed to note that one of the components has two special bolts that are made only in another country. There is not time to design a new bolt if the terms of the contract are to be met. USAWAY is a major customer, and not meeting the deadline can be expected to have unfortunate consequences for Clarke.
Sequencing DNA with Linux Cores and Nanopores
Creators: name: Eccles, David
Publisher: name: Zenodo
Year: 2019
Subjects: nanopore
sequencing
education
outreach

description: Sequenced reads (including signal-containing FAST5 files) from sequencing runs carried out as part of preparation for my LCA 2019 talk: Sequencing DNA with Linux Cores and Nanopores.

This is a mixed yoghurt, tomato and strawberry sample. DNA was extracted using the Qiagen PowerWater kit, and concentrated using Ampure XP beads to 18ng/μl. 7.5μl of the concentrated DNA sample was then processed with the Oxford Nanopore Rapid Barcoding kit, and sequenced for 15 minutes on an Oxford Nanopore MinION.

This is a backup dataset for my demonstration at the conference, in the very likely event that sample preparation does not produce sufficient amounts of DNA on the day for a good 15-minute sequencing run. It will be updated after the conference with any additional sequencing runs that are carried out.

If you're interested in purchasing the "genes in a T-shirt" that I'll probably be wearing during my talk, here's the Zazzle link to my virtual shop:

https://www.zazzle.co.nz/gringene
title: Pharmacotherapy Use in Older Patients with Heart Failure and Reduced Ejection Fraction Living in Skilled Nursing Facilities
Creators: name: Li, Lin
name: Jesdale, William M.
name: Hume, Anne
name: Gambassi, Giovanni
name: Goldberg, Robert J.
name: Lapane, Kate L.
Publisher: name: eScholarship@UMMS
Year: 2017

description: Background: Little is known about the use of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) and β-blockers among older adults with heart failure and reduced ejection fraction (HFrEF) in skilled nursing facilities (SNFs).

Methods: Using national data Minimum Data Set 3.0 cross-linked with Medicare data (2011-2012), we studied 31,675 patients with HFrEF (ICD-9 codes: 428.2 or 428.4) aged ≥65 years admitted to 9,659 SNFs. We estimated the prevalence of a Part D claim for ACEIs/ARBs or β-blockers during 3 months before the SNF stay and used log-binomial models to evaluate correlates of use by estimating prevalence ratios (PR) and 95% confidence intervals (CI).

Results: The median age of the study population was 83 years, 60% were women, and 10% and 4% were African Americans and Hispanics, respectively. Approximately 46% had ≥3 important risk factors for HFrEF. Fifty-seven percent received an ACEI/ARB and 47% a β-blocker; 25% received neither. Older age was inversely associated with receipt of these therapies: adjusted PRs were 0.94 (95% CI: 0.91-0.96) for ACEIs/ARBs and 0.86 (95% CI: 0.84-0.89) for β-blockers for patients aged ≥85 years compared with those aged 65-74 years. Compared with Whites, use of these therapies was higher among African Americans (adjusted PRs were 1.07 [95% CI: 1.04-1.10] for ACEIs/ARBs and 1.11 [95% CI: 1.08-1.15] for β-blockers) and Hispanics (adjusted PRs were 1.13 [95% CI: 1.09-1.18] for ACEIs/ARBs and 1.12 [95% CI: 1.07-1.18] for β-blockers). The prevalence of ACEI/ARB use was greater in patients with ≥3 important risk factors than in those with ≤1 factor: adjusted PR was 1.16 (95% CI 1.13-1.19).

Conclusions: Use of guideline-directed medications may be suboptimal in older patients with HFrEF receiving SNF care. Whether this is a result of adverse drug events from prior use or insufficient evidence in vulnerable populations needs to be examined.

Acknowledgements: Lin Li has received funding from a National Institutes of Health Ruth L. Kirschstein National Research Service Award Institutional Research Training Grant (5T32HL120823-02)
Question of Delegating Responsibilities
Publisher: name: Online Ethics Center
Year: 2006
Subjects: Employer/Employee Relationships
Ethics and Society
Public Well-being
Research and Practice
Risk
Safety
Social Responsibility
Workplace Ethics

description: Dan Dorset had been looking forward to this trip for weeks. Once he was assigned to help Rancott install its equipment for Boulding, Inc., he arranged his vacation at a nearby ski resort. The installation would be completed on the 12th, and his vacation would begin on the 13th. Unfortunately, not all of Rancott's equipment arrived on time.
Associations between socio-economic status and school-based physical Activity. A scoping review
Creators: name: Cheval, Boris
name: Chalabaev, Aïna
name: SAOUDI, Ilyes
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Social and Behavioral Sciences

description: The aims of this scoping review are to: 1. Assess whether and to what extent school, classroom and/or student’s SES is associated with school-based PA. 2. Identify what theoretical models and type of methodology have been used to examine these associations.
Reactor antineutrino monitoring with a plastic scintillator array as a new safeguards method
Creators: name: Oguri, S.
name: Kuroda, Y.
name: Kato, Y.
name: Nakata, R.
name: Inoue, Y.
name: Ito, C.
name: Minowa, M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We developed a segmented reactor-antineutrino detector made of plastic scintillators for application as a tool in nuclear safeguards inspection and performed mostly unmanned field operations at a commercial power plant reactor. At a position outside the reactor building, we measured the difference in reactor antineutrino flux above the ground when the reactor was active and inactive.
description: 25 pages, 9 figures; Typos in Figure 6 corrected
title: Selective Environmentally Benign Synthesis of Isotope Labeled Compounds: Introduction of Deuterium into Compounds of Medicinal Relevance
Creators: name: Kokel, Anne
name: Kadish, Dora
name: Torok, Bela
Publisher: name: eScholarship@UMMS
Year: 2017

description: Deuterium (2H) is a less abundant isotope of hydrogen that possesses an additional neutron resulting in significant differences in the properties of a 1H-containing-molecule compared to its 2H homologues. Deuterium labeled organic compounds are valuable in medicinal chemistry as they offer widespread applications. For instance, in imaging deuteratium labeling can serve as biological tracers, thus, deuterated drugs can provide better understanding of the metabolic pathways; they can also help localize the metabolites of the drug and assess their toxicity. While metabolic enzymes easily transform drug molecules to metabolites that the body can excrete, the introduction of deuterium to drugs appears to strengthen the resistance of drugs toward metabolism. In fact, the carbon-deuterium bond is known to be six to ten times stronger than its C-1H counterpart. The higher the stability, the longer the drug remains intact, which allows lower dosage, potentially causing fewer side effects. Due to the carbon-deuterium bond strength, deuterated drugs can also prevent the formation of toxic metabolites observed with its hydrogen-containing homologue.

There are several known methods for the introduction of deuterium to organic compounds; most methods, however, do not conform to the recent expectations and standards of sustainable synthesis. Therefore, a green synthesis of deuterated organic compounds would be an important advance in producing these compounds in an environmentally sustainable way. Thus, we have turned our attention to the Al-H2O system that is commonly applied for hydrogenation reactions. Replacing the H2O with its deuterated version D2O in the system constitutes an easy, economic and safe source of deuterium. The application of either the commercially available Ni-Al alloy or Al in combination with Pd, a common hydrogenation catalyst, for the H-D exchange of compounds with reactive C-H bonds was performed, while yielding no harmful byproducts. The low reactivity of the aluminum metal was significantly enhanced by the application of ultrasonic irradiation prior to the reaction. The H-D exchange reaction was carried out under microwave irradiation and achieved good yields in no more than 1h. The success of the method was demonstrated by applying a broad variety of compounds from essential amino acids to actual drug compounds.
Cost of Design Improvement
Publisher: name: Online Ethics Center
Year: 2006
Subjects: Corporate Social Responsibility
Engineer/Client Relationships
Ethics and Society
Research and Practice
Social Responsibility
Workplace Ethics

description: WPI begins production and ships the first portion of the order to GFI on time. GFI, at this point, is very happy with the component and wants WPI to ship the final three quarters of the order as soon as feasible. As Philip is working on the component he thinks of an apparent solution to the 'nagging problem' that bothered him in the design. It would involve a small change in the production process, while increasing the cost to three dollars more per component. Philip is convinced that, had they known about this improvement earlier, GFI would have wanted it.
Optical and Ultraviolet Observations of the Narrow-Lined Type Ia SN 2012fr in NGC 1365
Creators: name: Zhang, JuJia
name: Wang, XiaoFeng
name: Bai, JinMing
name: Zhang, TianMeng
name: Wang, Bo
name: Liu, ZhengWei
name: Zhao, XuLin
name: Chen, JunCheng
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Extensive optical and ultraviolet (UV) observations of the type Ia supernova (SN Ia) 2012fr are presented in this paper. It has a relatively high luminosity, with an absolute $B$-band peak magnitude of about $-19.5$ mag and a smaller post-maximum decline rate than normal SNe Ia [e.g., $Δm _{15}$($B$) $= 0.85 \pm 0.05$ mag]. Based on the UV and optical light curves, we derived that a $^{56}$Ni mass of about 0.88 solar masses was synthesized in the explosion. The earlier spectra are characterized by noticeable high-velocity features of \ion{Si}{2} $λ$6355 and \ion{Ca}{2} with velocities in the range of $\sim22,000$--$25,000$ km s$^{-1}$. At around the maximum light, these spectral features are dominated by the photospheric components which are noticeably narrower than normal SNe Ia. The post-maximum velocity of the photosphere remains almost constant at $\sim$12,000 km s$^{-1}$ for about one month, reminiscent of the behavior of some luminous SNe Ia like SN 1991T. We propose that SN 2012fr may represent a subset of the SN 1991T-like SNe Ia viewed in a direction with a clumpy or shell-like structure of ejecta, in terms of a significant level of polarization reported in Maund et al. (2013).
description: 14 pages, 11 figures, 9tables. Accepted for publication in AJ
Software developers, moods, emotions, and performance
Creators: name: Graziotin, Daniel
name: Wang, Xiaofeng
name: Abrahamsson, Pekka
Publisher: name: arXiv
Year: 2014
Subjects: subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: Studies show that software developers' happiness pays off when it comes to productivity.
description: 6 pages. Accepted (before copyediting and typesetting) version
title: Combination Photodynamic Therapy and Chemotherapy for Temozolomide-Resistant Glioblastoma
Creators: name: Kydd, Janel
name: Jadia, Rahul
name: Rai, Prakash
Publisher: name: eScholarship@UMMS
Year: 2017

description: Polymer based nanoparticles (NPs) are useful vehicles for drug therapy in treating glioblastoma because of their ideal characteristics such as small size, to cross the blood-brain barrier, and bind to overexpressed transferrin receptors via peptide conjugation and surface modification of NPs. The use of a photosensitizer drug such as verteporfin, or BPD, in combination with a repurposed drug, Cediranib (CED), prepared as a nanoparticle therapy will provide the medical field with new research on the possible ways to treat glioblastoma. BPD-CED-loaded NPs have the potential to induce cytotoxicity in glioblastoma cells by 1) remotely triggering BPD through photodynamic therapy by irradiating laser at 690 nm and subsequent production of reactive oxygen species and 2) anti-angiogenesis mechanisms which may allow for longer progression free survival in patients and fewer systemic side effects due to the nanoparticle drug delivery. The specific aims of this research were to synthesize, using nanoprecipitation, and characterize pegylated and transferrin-peptide conjugated PLGA-CED NPs, PLGA-BPD NPs, and PLGA-BPD-CED NPs which were less than 100 nm in size for enhanced permeation and retention effects. NPs were characterized using dynamic light scatter (DLS) to determine particle size, PDI, and zeta potential, while absorbance spectroscopy was used to find encapsulation efficiency of loaded drugs. Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) were used to obtain topographical and 3-D structural imaging of NPs. The cytotoxicity of the free drugs, targeted and non-targeted single and dual-drug-loaded NPs was evaluated using MTT assay in the U87-MG cell line. MTT assay results showed increased cell death by combination nanoparticles. The size, PDI, zeta potential and encapsulation efficiency of synthesized nanoparticles were acceptable. The major goal of this research was to investigate a new combination of photodynamic-chemotherapy drugs in NP formulation to provide for a more effective targeted cell therapy in glioblastoma patients.
Radio frequency occupancy state control of a single nanowire quantum dot
Creators: name: Weiß, Matthias
name: Schülein, Florian J. R.
name: Kinzel, Jörg B.
name: Heigl, Michael
name: Rudolph, Daniel
name: Bichler, Max
name: Abstreiter, Gerhard
name: Finley, Jonathan J.
name: Wixforth, Achim
name: Koblmüller, Gregor
name: Krenner, Hubert J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Optics (physics.optics)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The excitonic occupancy state of a single, nanowire-based, heterostructure quantum dot is dynamically programmed by a surface acoustic wave. The quantum dot is formed by an interface or thickness fluctuation of a GaAs QW embedded in a AlGaAs shell of a GaAs-AlGaAs core-shell nanowire. As we tune the time at which carriers are photogenerated during the acoustic cycle, we find pronounced intensity oscillations of neutral and negatively charged excitons. At high acoustic power levels these oscillations become anticorrelated which enables direct acoustic programming of the dot's charge configuration, emission intensity and emission wavelength. Numerical simulations confirm that the observed modulations arise from acoustically controlled modulations of the electron and electron-hole-pair concentrations at the position of the quantum dot.
description: Revised manuscript, 12 pages, submitted to J. Phys. D as a contribution in a Special Issue on Nanowires
Probing Gluon Saturation through Dihadron Correlations at an Electron-Ion Collider
Creators: name: Zheng, L.
name: Aschenauer, E. C.
name: Lee, J. H.
name: Xiao, Bo-Wen
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Two-particle azimuthal angle correlations have been proposed to be one of the most direct and sensitive probes to access the underlying gluon dynamics involved in hard scatterings. In anticipation of an Electron-Ion Collider (EIC), detailed studies of dihadron correlation measurements in electron-proton and electron-ion collisions at an EIC have been performed. The impact of such measurements on the understanding of the different gluon distribution functions, as a clean signature for gluon saturation and to constrain saturation models further, has been explored. It is shown that dihadron correlation measurements will be one of the key methods to probe gluon saturation phenomena at a future EIC.
description: 13 pages, 13 eps figures
Large Projects for Small building construction companies: from the Key Diagram, to the Architectural Model, to the Local Plan
Creators: name: Pedrocco, Piero
Publisher: name: UPLanD - Journal of Urban Planning, Landscape & environmental Design
Year: 2020

description: Along 2016-2019, some educational experiments on the planning of large urban neighbourhoods were developed at the Laboratorio Integrato di Progettazione Urbanistica of Udine University, coordinated by the author with the participation of the architect Elena Olivo and the engineer Giorgio Verri. The attempt is to reverse the traditional urban planning process, anticipating the Volumetric Project, to arrive at the Local Plan only at a later time. Three cities were used: Venice, Udine and Treviso. In Venice compact forms of the lagoon settlements have been designed. Here we tried to rebalance the city with respect to the mainland districts, creating transfer opportunities for inhabitants scattered throughout the metropolitan area, and promoting a new lagoon architecture. In Udine and Treviso forms of infilling, compaction and urban regeneration were sought, with the aim of reducing the sprawl and the spread and to provide urban areas for the construction of buildings demolished in the open countryside for the purposes of landscape refurbishment. The method used is: divide the students into project groups; draw up a Key Diagram of strategies; assign an area to every group; develop analyses on the city and its historical centre and use them to design the urban areas on a 1:1000 scale; join them together in a single project and realize the volumetric model; sketch up some architectures on a 1:100 scale; finally draw up the Local Plan of the whole borough.
description: UPLanD - Journal of Urban Planning, Landscape & environmental Design, V. 5 N. 2: Healthy City
The Gladiator Sparrow: Ethical Issues in Behavioral Research on Captive Populations of Wild Animals
Publisher: name: Online Ethics Center
Year: 2006
Subjects: Animal Use
Conflict of Interest
Mentors and Trainees
Research and Practice

description: This case discusses whether humans should consider animal suffering and sentience when conducting research; and, who is stopping an experiment justified on the grounds that animal welfare takes precedence over human intellectual endeavor?
title: Clot Characterization in Acute Ischemic Stroke
Creators: name: Litchman, Joshua
name: Chueh, Juyu
name: Arslanian, Rose
name: Vedantham, Srinivasan
name: Carniato, Sarena
name: Rex, David E.
name: Howk, Mary
name: Gounis, Matthew J.
name: Puri, Ajit S.
Publisher: name: eScholarship@UMMS
Year: 2017

description: Background: In the treatment of acute ischemic stroke (AIS) with mechanical thrombectomy, revascularization depends upon integration of the thrombus into the retrieval device. The histologic and mechanical characteristics of thrombi are key determinants of effective thrombus-device interaction. Thrombi with greater calcium and fibrin content have been associated with more challenging thrombus retrievals.

Objective: To develop thrombus analogs with histologic and mechanical characteristics similar to those of challenging clinical thrombi for thrombectomy device testing.

Methods: Fifty thrombi were retrieved from twenty-nine patients with AIS. Clinical thrombi underwent histologic analysis to determine erythrocyte and fibrin content. Nine clinical thrombi underwent dynamic mechanical analysis to determine thrombus stiffness, which was defined as a function of stress variation at low and high strains. Results from the clinical thrombi were used to determine the key mechanical characteristics of the challenging thrombus analogs, the calcium apatite-rich and fibrin-rich thrombus analogs.

Results: Of the twenty-nine AIS cases, fifteen required multiple pass attempts. The average histologic composition of the challenging clinical thrombi was 26% erythrocyte, 54% fibrin, and 20% mixed. The average stiffness of the challenging clinical thrombi was found to be similar to that of the fibrin-rich thrombus analogs. Addition of calcium apatite increased the stiffness of the thrombus analogs at low strain approximately five-fold.

Conclusions: Thrombus analogs with mechanical characteristics similar to those of challenging clinical thrombi were successfully developed. The calcium apatite-rich thrombus analogs were found to be stiffer than the fibrin-rich red thrombus analogs.
Magnetic structure and domain conversion of quasi-2D frustrated antiferromagnet CuCrO2 probed by NMR
Creators: name: Sakhratov, Yu. A.
name: Svistov, L. E.
name: Kuhns, P. L.
name: Zhou, H. D.
name: Reyes, A. P.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We have carried out 63,65Cu NMR spectra measurements in magnetic field up to about 15.5 T on single crystal of a multiferroic triangular-lattice antiferromagnet CuCrO2. The measurements were performed for perpendicular and parallel orientation of the magnetic field with respect to the c-axis of the crystal, and the detailed angle dependence of the spectra on the magnetic field direction within ab-plane was studied. The shape of the spectra can be well described in the model of spiral spin structure proposed by recent neutron diffraction experiments. When field is rotated perpendicular to crystal c-axis, we observed, directly for the first time, a remarkable reorientation of spin plane simultaneous with rotation of the incommensurate wavevector by quantitatively deducing the conversion of less energetically favorable domain to a more favorable one. At high enough fields parallel to c-axis, the data are consistent with either a field-induced commensurate spiral magnetic structure or an incommensurate spiral magnetic structure with a disorder in the c direction, suggesting that high fields may have influence on interplanar ordering.
description: 8 pages, 10 figures
title: Sex Differences in Neighborhood Perceptions and Physical Activity among Older Adults Living in Car-dependent Neighborhoods
Creators: name: Li, Wenjun
name: Churchill, Linda C.
name: Crouter, Scott
name: Kane, Kevin J.
name: Cheng, Jie
name: Rui, Fuding
name: Tian, Jie
name: Franklin, Patricia D.
name: Ockene, Judith K.
name: Gurwitz, Jerry H.
Publisher: name: eScholarship@UMMS
Year: 2017

description: INTRODUCTION: Older adults may have more physical limitations and no longer routinely travel outside their neighborhoods to work. Their daily living, health, and well-being may depend on neighborhood resources close to their homes. Therefore, access to resources critical for healthy aging may influence health in various aspects. In this study we investigated differences in neighborhood perceptions (NP) and their influences on physical activity (PA).

METHODS: Between 2012 and 2015, 111 men and 103 women aged 65 years and older living in car-dependent neighborhoods were queried on NP, use of neighborhood resources, and frequency and location of PA. Participants wore an accelerometer for 7 consecutive days.

RESULTS: Compared to women, men had a higher daily step count (mean (SD) 4385 (2122) men vs. 3671(1723) women, p=0.008). Men reported higher frequencies of any PA and moderate-to-vigorous PA, and a lower frequency of PA inside the home. Mean daily step counts and frequency of PA outside the home decreased progressively with age for both genders. Women had a sharper decline in frequencies of self-reported PA. Men had a significant decrease in utilitarian walking, which women did not (p=0.07). Among participants who reported any PA (n=190), more women indicated exercising indoors more often than outdoors (59% vs. 44%, p=0.04). Men perceived their neighborhoods more favorably than women. However, women perceived better accessibility to neighborhood resources. Higher NPs were associated with more frequent total PA and exercise outside the home. Association of NP with recreational walking was limited to men whereas association of NP with utilitarian walking was limited to women.

CONCLUSION: Older men and women differed in levels, types and location preferences of PA, NPs and their influences on PA. Consideration of these sex differences is necessary to improve the effectiveness of active living promotion programs among older adults, especially those targeting NPs.
Some integral representations and properties of Lah numbers
Creators: name: Guo, Bai-Ni
name: Qi, Feng
Publisher: name: arXiv
Year: 2014
Subjects: subject: Combinatorics (math.CO)
subject: Classical Analysis and ODEs (math.CA)
subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 05A10, 05A19, 05A20, 11B34, 11B37, 11B65, 11B75, 11B83, 11R33, 11Y35, 11Y55, 26A48, 26A51, 33B10, 33C15, 33C20

description: In the paper, the authors find some integral representations and discover some properties of Lah numbers.
description: 6 pages
On a new collection of words in the Catalan family
Creators: name: Stump, Christian
Publisher: name: arXiv
Year: 2014
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05A19

description: In this note, we provide a bijection between a new collection of words on nonnegative integers of length n and Dyck paths of length 2n-2, thus proving that this collection belongs to the Catalan family. The surprising key step in this bijection is the zeta map which is an important map in the study of q,t-Catalan numbers. Finally we discuss an alternative approach to this new collection of words using two statistics on planted trees that turn out to be closely related to the Tutte polynomial on the Catalan matroid.
description: 5 pages, v2: title changed + fixed typos; final version
Can topological defects mimic the BICEP2 B-mode signal?
Creators: name: Lizarraga, Joanes
name: Urrestilla, Jon
name: Daverio, David
name: Hindmarsh, Mark
name: Kunz, Martin
name: Liddle, Andrew R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We show that the B-mode polarization signal detected at low multipoles by BICEP2 cannot be entirely due to topological defects. This would be incompatible with the high-multipole B-mode polarization data and also with existing temperature anisotropy data. Adding cosmic strings to a model with tensors, we find that B-modes on their own provide a comparable limit on the defects to that already coming from Planck satellite temperature data. We note that strings at this limit give a modest improvement to the best-fit of the B-mode data, at a somewhat lower tensor-to-scalar ratio of $r \simeq 0.15$.
description: 3 pages, 4 figures; Minor changes, matches published version
A Young Woman's Struggle for Peace
Publisher: name: Online Ethics Center
Year: 2006
Subjects: Conflict of Interest
Controversies
Cultural Awareness and Sensitivity
Dual Use Research
Ethics and Society
Human Rights
Mentors and Trainees
Military and Defense Research
Public Well-being
Research and Practice
Security
Social and Political Conflict
Social Responsibility

description: This case discusses the problems faced by a researcher when trying to reconcile faith with science, personal convictions and professional activities.
Contrasting the wide Feshbach resonances in $^6$Li and $^7$Li
Creators: name: Julienne, Paul S.
name: Hutson, Jeremy M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We compare and contrast the wide Fehbach resonances and the corresponding weakly bound states in the lowest scattering channels of ultracold $^6$Li and $^7$Li. We use high-precision measurements of binding energies and scattering properties to determine new interaction potentials, incorporating non-Born-Oppenheimer terms to account for the failure of mass scaling between $^6$Li and $^7$Li. Correction terms are needed for both the singlet and the triplet potential curves. The universal formula relating binding energy to scattering length is not accurate for either system. The $^6$Li resonance is open-channel-dominated and the van der Waals formula of Gao [J. Phys. B 37, 4273 (2004)] gives accurate results for the binding energies across much of the resonance width. The $^7$Li resonance, by contrast, is weakly closed-channel-dominated and a coupled-channels treatment of the binding energies is required. Plotting the binding energies in universal van der Waals form helps illustrate subtle differences between the experimental results and different theoretical forms near the resonance pole.
description: Version as published, with some typographical errors fixed in the equations and improved versions of Figs. 6 and 7
title: Emotional Eating is Associated with Intake of Energy-dense Foods in Latinos
Creators: name: Lopez-Cepero, Andrea
name: Frisard, Christine
name: Lemon, Stephenie C.
name: Rosal, Milagros C.
Publisher: name: eScholarship@UMMS
Year: 2017

description: Background: Latinos experience profound health disparities in diet-related chronic conditions. Emotional eating (EE) has been positively associated with such conditions, however, little is known about the relationship between EE and energy-dense food intake that may influence risk for developing these conditions.

Objective: To examine associations between EE and energy-dense food intake in Latino men and women.

Methods: Latino individuals were recruited from a community health center in Lawrence, MA. Participants completed standardized assessments. EE was measured with the Three Factor Eating Behavior Questionnaire R18-V2. Dietary intake was measured with a culturally tailored Food Frequency Questionnaire. Energy-dense food groups defined as food groups exceeding 225calories per 100 grams were identified. Covariates considered in this analysis included: age, sex, education, employment status and BMI. Statistical analysis consisted of multivariable logistic regression.

Results: A total of 201 participants were included in this analysis (53.7% female, 68.1% Dominicans). After adjusting for covariates, EE was significantly associated with high intake of sweet and/or fatty foods, namely dairy desserts (i.e., ice-cream, sherbet and frozen yogurt) (OR=1.55; 95%CI=1.08, 2.21; p=0.017), oleaginous fruits (i.e., nuts and seeds) (OR=1.44; 95%CI=1.01, 2.05; p=0.046) and baked goods (i.e., cakes, cookies, pies, doughnuts and muffins) (OR=1.54; 95%CI=1.07, 2.20; p=0.020).

Conclusion: EE was positively associated with consumption of energy-dense foods in this Latino sample. Future studies should examine longitudinal associations between EE, intake of energy-dense foods and risk of chronic health conditions. Understanding these associations can unveil potential intervention targets for Latinos at high risk of diet-related chronic health conditions.

Also presented at the Experimental Biology 2017 Annual Conference, Chicago, IL.