cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Investigation of the Mesenchymal Manifestations of Tuberous Sclerosis Complex using Tissue-Engineered Disease Models
Creators: name: Pietrobon, Adam Derrick
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2021
Subjects: tuberous sclerosis complex
tissue engineering
disease modelling
mTORC1
lung-mimetic hydrogels
renal organoids
genome engineering
pluripotent stem cells
disease pathogenesis
therapeutics development

description: Tuberous sclerosis complex (TSC) is a multisystem tumor-forming disorder caused by biallelic inactivation of TSC1 or TSC2. The primary cause of mortality arises from mesenchymal manifestations in the lung and kidney: pulmonary lymphangioleiomyomatosis (LAM) and renal angiomyolipomas (RAMLs). Despite a well-described monogenic etiology, there remains an incomplete understanding of disease pathogenesis. Consequentially, tractable models which fully recapitulate disease characteristics are lacking. Here, I develop and study novel tissue-engineered models of TSC lung and kidney disease. In my first chapter, I demonstrate that lung-mimetic hydrogel culture of pluripotent stem cell-derived diseased cells more faithfully recapitulates human LAM biology compared to conventional culture on two-dimensional plastic. Leveraging this culture system, I conducted a three-dimensional drug screen using a custom 800-compound library, tracking cytotoxicity and invasion modulation phenotypes at the single cell level. I identified histone deacetylase (HDAC) inhibitors as a group of anti-invasive agents that are also selectively cytotoxic towards TSC2-/- cells. HDAC inhibitor therapeutic effects remained consistent in vivo upon xenotransplantation of LAM cellular models into zebrafish. In my second chapter, I develop a genetically-engineered human renal organoid model which recapitulates pleiotropic features of RAMLs in vitro and upon orthotopic xenotransplantation. I find that loss of TSC1/2 affects multiple developmental processes in the renal epithelial, stromal, and glial compartments. First, loss of TSC1/2 leads to an expanded stroma by favouring stromal cell fate acquisition and alters terminal stromal cell identity. Second, epithelial cells in the TSC1/2-/- organoids exhibit a rapamycin-insensitive epithelial-to-mesenchymal transition. Third, a melanocytic population forms exclusively in TSC1/2-/- organoids, branching from MITF+ Schwann cell precursors of a bona fide neural crest-to-Schwann cell differentiation trajectory. Through these two thesis chapters, I realize the power of tissue-engineered models for the study of TSC. This work offers novel insights into the pathogenesis of RAMLs and identifies a new class of therapeutics suitable for trialing in patients with pulmonary LAM.
Geographic variation in seed weight, some cone scale measurements and seed germination of Douglas-fir Pseudotsuga menziesii (Mirb.) Franco
Creators: name: Yao, Chang
Publisher: name: University of British Columbia
Year: 2011

description: The principal objectives of the study were to investigate geographic variation of, and relationship between, 1000-seed weight and cone-scale morphology and variation of germination percent of Douglas-fir ( Pseudotsuga menziesii (Mirb.) Franco ) from within its natural range in Northwest America. One hundred twenty four seed sources representing eight climatic regions from British Columbia to California (lat. 38°50' to 53°37', long. 117°00' to 127°27') were collected in 1966 and 1968 by the International Union of Forestry Research Organizations, Section 22. From the seed samples, filled seed (which constituted 1000-seed weight) were selected using soft X-ray fluoroscopy. Five cone-scale measurements were taken; cone-scale width, bract width, cone-scale length, 1st prong length and 2nd prong length. The position of the bract in relation to the scale was rated. For germination testing, 56 filled seeds were selected to represent each of 12 trees in each of 114 provenances. The total of 76,608 seeds from 1,368 individual trees were sown untreated in two replications on ten relatively uniform nursery beds during May, 1969. Seed weights varied greatly. One thousand-seed weight increased clinally from low to high elevation and from north to south. Latitude appeared to affect seed weights more than elevation. Cone-scale characteristics differed significantly from tree to tree, provenance to provenance, as well as sub-region to sub- region. Cone-scale widths and lengths were only significantly different between regions. These characteristics again showed a clinal variation which increased from low to high elevations and from north to south in some regions, and revealed that latitude affected cone-scale morphology more than elevation. Thousand-seed weights were generally positively correlated with cone-scale size. Germination percent was significantly affected by latitude around 36 days after sowing, but this effect disappeared by 50 days. Elevation and longitude appeared not to affect germination percent during the observed period (0 - 92 days after sowing). The results of this study illustrate the importance of geographic origin as a source of phenotypic variability in Douglas-fir.
Modeling Motility of the Kinesin Dimer from Molecular Properties of Individual Monomers
Creators: name: Fan, Dagong
name: Zheng, Wenwei
name: Hou, Ruizheng
name: Li, Fuli
name: Wang, Zhisong
Publisher: name: arXiv
Year: 2009
Subjects: subject: Biological Physics (physics.bio-ph)
subject: FOS: Physical sciences

description: Conventional kinesin is a homodimeric motor protein that unidirectionally transports organelles along filamentous microtubule (MT) by hydrolyzing ATP molecules. This study shows that the load modulations of ATP turnover and head diffusion are both essential in determining the performance of the dimer under loads. It is found that the consecutive run length of the dimer critically depends upon a few pathways, leading to the detachment of individual heads from MT. Modifying rates for these detachment pathways changes the run length but not the velocity of the dimer, consistent with mutant experiments. The run length may increase with or without the ATP concentration, depending upon a single rate for pure mechanical detachment. This finding provides an explanation to a previous controversy concerning ATP dependence of the run length, and related quantitative predictions of this study can be tested by a future experiment. This study also finds that the experimental observations for assisting loads can be quantitatively explained by load-biased head diffusion. We thus conclude that the dimer motility under resisting as well as assisting loads is governed by essentially the same mechanisms.
description: 6 figures
Becoming Housed: Autonomy, Embeddedness, and Ambiguity in Housing First Case Management
Creators: name: Buist, Heather
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2021
Subjects: anthropology
homelessness
autonomy
housing

description: Housing First is a housing model aimed at solving chronic homelessness. It works by offering housing to unhoused people without requiring them to get certain treatments, which reverses previous models. In this ethnographic study, I investigated how this program operates on the ground level, by interviewing and shadowing several case managers who work with clients who experience homelessness, addiction, and mental illnesses. What my research reveals are the tensions that emerge in the process of implementing Housing First programs. I explore how case managers shape the client’s choices and their relationships, to see how some forms of autonomy are valued over others and how clients are made to be individuals in some ways and a part of a community in others. Additionally, I show how case managers navigate ethical practice when the needs of the client conflict with the needs of the organizations for which the case manager works. This intervention is thought to be a solution to a widespread social problem. However, in practice, it is a market-based solution that can only work on an individual level. This results in the reinforcement of liberal understandings of autonomy and responsibility that contributed to the creation of homelessness as a social problem in the first place.
TURAS Exploitation Strategy: Deliverable 8.4 of the TURAS Project
Creators: name: McQuaid, Siobhán
name: Schuchmann, Svenja
name: Collier, Marcus J.
Publisher: name: Zenodo
Year: 2011
Subjects: Resilience
Exploitation
Cities
Urban
Strategy
Urban planning
Urban transformation
Sustainability
Urban sprawl
Urban Policy

description: The objectives of these events were to disseminate and exchange the solutions developed within the framework of TURAS foremost with other local authority officials but also with interested politicians, SMEs, academic institutions and the public. The events enabled an exchange on TURAS outcomes with actors outside the TURAS project especially regarding their adaptation to varying local contexts. These events have contributed significantly to the effective exploitation of TURAS results by the target group. The events took place either on a regional, national or international scale. They were free of charge and widely promoted through the TURAS communication channels and through the communication channels of the partners organising the events. For additional information on the TURAS project see here, or email marcus.collier@tcd.ie.
description: Suggested citation: McQuaid, S., Schuchmann, S. and Collier, M.J. (2011) TURAS Exploitation Strategy. Deliverable 8.4 of the TURAS FP7 Project. Available at: https://doi.org/10.5281/zenodo.3941799.
Fanfare for the Common Good (CORNET)
Creators: name: Elia, Anthony J.
Publisher: name: Columbia University
Year: 2013
Subjects: Music

description: This was one of various works for brass ensemble, inspired by a community band ensemble in Lawrence, Kansas. This evening concert was attended by the composer in late June 2013, and performed works, which included selections from Giuseppe Verdi's Nabucco. The "Fanfare for the Common Good" is a work dedicated to human good, progress, and community. It is arranged for 2 horns, B-flat Trumpet, B-flat Cornet, and Trombone. Tempi at discretion of conductor.
The Environmental Impacts of Digitally Enabled Mobility Platforms
Creators: name: Basak, Ecem
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: Uncategorized

description: Mobility services, shared modes, electrification, and automation have been transforming how cities are planned and how individuals travel. These platforms are the services that are available to individuals on an as-needed basis for short-term transportation purposes. Even though the main mission of digitally-enabled mobility platforms is to provide a reliable transportation option to everyone, these platforms can trigger environmental sustainability externalities. They have the potential to become one of the green solutions to unsustainable practices in urban areas. This could be achieved by the efficient use of these platforms causing a decrease in energy consumption, emissions, and congestion. In this dissertation, we aim to chart a new direction in Information Systems literature and to investigate the relationship between digitally-enabled mobility platforms and environmental sustainability. In the first essay, we discuss the total causal impacts of bike-sharing platforms on air quality as well as heterogeneous impacts. Air pollution is a universal problem that needs to be tackled by countries for better air quality and public health. The demand for the mobility of individuals as well as goods by road makes the problem of air pollution especially critical. In the second essay, we explore the underlying causal mechanisms between ride-hailing platforms and traffic congestion as well as the underlying mechanisms. Despite the increasing number of scientific studies and projects, the debate on the impact of ride-hailing services on congestion has produced conflicting results and has thus far failed to reach a convincing consensus on this important research question that has serious implications for urban policy. Moreover, we still lack knowledge of how much of the impact on traffic congestion is related to the indirect effect of the ride-hailing platforms. Overall, the central theme of this dissertation is to provide causal evidence that strengthens our understanding of the relationship between digitally-enabled mobility platforms and their impact on environmental sustainability.
Hysteresis in the electronic transport of V2O3 thin films: non-exponential kinetics and range scale of phase coexistence
Creators: name: Grygiel, C.
name: Pautrat, A.
name: Prellier, W.
name: Mercey, B.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The thermal hysteresis of the electronic transport properties were studied for V2O3 thin films. The temporal evolution of the resistance shows the out-of-equilibrium nature of this hysteresis with a very slow relaxation. Partial cycles reveal not only a behavior consistent with phase coexistence, but also the presence of spinodal temperatures which are largely separated. The temperature spreading of phase coexistence is consistent with the bulk phase diagram in the pressure-temperature plane, confirming that the film is effectively under an effective pressure induced by the substrate.
description: Accepted for publication in Europhysics Letters
Additional file 1 of Genetic risk factors for autoimmune hepatitis: implications for phenotypic heterogeneity and biomarkers for drug response
Creators: name: Higuchi, Takashi
name: Shomi Oka
name: Furukawa, Hiroshi
name: Tohma, Shigeto
name: Yatsuhashi, Hiroshi
name: Migita, Kiyoshi
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1: Supplementary Table S1. Logistic regression analysis of DPB1 alleles in AIH patients and controls.
Tailoring the local density of states of non-radiative field at the surface of nanolayered materials
Creators: name: Ben-Abdallah, Philippe
name: Joulain, Karl
name: Drevillon, Jérémie
name: Domingues, Gilberto
Publisher: name: arXiv
Year: 2009
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The ability to artificially grow in a controllable manner at nanoscale, from modern deposition techniques, complex structural configurations made with metallic, polar and semiconductors materials raises today the issue of the "best" achievable inner structure to tailor the near-field properties of a nanostructured medium. In the present work we make a step towards the rational design of these materials by reporting numerical experimentations demonstrating the possibility of identifying structural configurations of layered metallodielectric media specifically designed to control the electromagnetic density of states in the close vicinity of their surface. These results could find broad applications in near-field technologies.
description: to appear in Appl. Phys. Lett
X-ray emission from GPS and CSS sources
Creators: name: Siemiginowska, Aneta
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Many X-ray observations of GigaHertz Peaked Spectrum and Compact Steep Spectrum sources have been made with Chandra X-ray Observatory and XMM-Newton Observatory over the last few years. The X-ray spectra contribute the important information to the total energy distribution of the compact radio sources. In addition the spatial resolution of Chandra allows for studies of the X-ray morphology of these sources on arcsec scales and provide a direct view of their environments. This paper gives a review of the current status of the X-ray observations and their contribution to our understanding of the nature of these compact radio sources. It also describes primary physical processes that lead to the observed X-ray emission and summarize X-ray emission properties expected from interactions between an expanding radio source and the intergalactic environment.
description: 6 pages, 9 figures, to appear in the proceedings of the '4th Workshop on Compact Steep Spectrum and Gigahertz-Peaked Spectrum Radio Sources', AN in press
Coordinating Deposit and Compliance
Creators: name: Kennison, Rebecca R.
Publisher: name: Columbia University
Year: 2013
Subjects: Library science
Information technology

description: In this presentation, given at the ARL Fall Forum 2013, Center for Digital Research and Scholarship director Rebecca Kennison outlines the challenges and opportunities academic libraries face in light of the White House Office of Science and Technology Policy's public access directive of February 22, 2013.
Nonadiabatic simulation study of photoisomerization of azobenzene: Detailed mechanism and load-resisting capacity
Creators: name: Shao, Junfeng
name: Lei, Yibo
name: Wen, Zhenyi
name: Dou, Yusheng
name: Wang, Zhisong
Publisher: name: arXiv
Year: 2009
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: Nonadiabatic dynamical simulations were carried out to study cis-to-trans isomerization of azobenzene under laser irradiation and/or external mechanical loads. We used a semiclassical electron-radiation-ion dynamics method that is able to describe the coevolution of the structural dynamics and the underlying electronic dynamics in a real-time manner. It is found that azobenzene photoisomerization occurs predominantly by an out-of-plane rotation mechanism even under a nontrivial resisting force of several tens of piconewtons. We have repeated the simulations systematically for a broad range of parameters for laser pulses, but could not find any photoisomerization event by a previously suggested in-plane inversion mechanism. The simulations found that the photoisomerization process can be held back by an external resisting force of 90 - 200 pN depending on the frequency and intensity of the lasers. This study also found that a pure mechanical isomerization is possible from the cis state if the azobenzene molecule is stretched by an external force of 1250 -1650 pN. Remarkably, the mechanical isomerization first proceeds through a mechanically activated inversion, and then is diverted to an ultrafast downhill rotation that accomplishes the isomerization. Implications of these findings to azobenzene-based nanomechanical devices are discussed.
description: 9 printed pages
Beat Them with Carrots: Implementing Strategies to Encourage Deposit
Creators: name: Kennison, Rebecca R.
Publisher: name: Columbia University
Year: 2013
Subjects: Library science
Information technology

description: In this talk, given as a Repositories Support Project webinar, Rebecca Kennison, Director of the Center for Digital Research and Scholarship at Columbia University, presents examples of how to encourage deposits for an institutional repository and how advocacy for deposits can be implemented among academics.
An interval version of separation by semispaces in max-min convexity
Creators: name: Nitica, Viorel
name: Sergeev, Sergei
Publisher: name: arXiv
Year: 2009
Subjects: subject: Metric Geometry (math.MG)
subject: FOS: Mathematics
subject: 52A01, 52A30, 08A72

description: We study separation of a closed box from a max-min convex set by max-min semispace. This can be regarded as an interval extension of known separation results. We give a constructive proof of the separation in the case when the box and the max-min convex set satisfy certain condition, and we show that separation is never possible if this condition does not hold. We also study separation of max-min convex sets by boxes and by box and semispace.
Heartland: for Brass Ensemble (TROMBONE)
Creators: name: Elia, Anthony J.
Publisher: name: Columbia University
Year: 2013
Subjects: Music

description: "Heartland" is another work for brass ensemble inspired by the community band performance attended by the composer in Lawrence, Kansas in late June 2013. This work is scored for 2 horns, B-flat trumpet, B-flat cornet, trombone, and Tuba in F. The work is of a more moderate to slow tempo, but can be up to the discretion of the conductor.
E-Book Program Development Study: Quarterly Report June 1 – August 31, 2013
Creators: name: Carroll, Jeffrey D.
name: Goertzen, Melissa J.
Publisher: name: Columbia University
Year: 2013
Subjects: Library science
Education and state
School management and organization

description: The E-Book Program Development Study is an ambitious assessment project aimed at gathering essential data to drive the development of policies related to e-book development programs. The results will provide a set of recommendations and strategies for internal and external stakeholders as they collaborate on the implementation of e-book initiatives. The objective of the first quarter was to review the e-book landscape at Columbia University Libraries and understand how needs and challenges across campus fit into the larger context of e-book management and collection development within the academic community.
Banjo Quartet (1st Movement)
Creators: name: Elia, Anthony J.
Publisher: name: Columbia University
Year: 2013
Subjects: Music

description: The Banjo Quartet (for Banjo, Violin, Viola, and ‘Cello) was inspired by the music of Béla Fleck. After hearing an interview of Fleck on a NYC radio show, along with classical works he had written, the composer set out to write works for banjo and mixed classical instrumentation. This is the first work for banjo written by Elia, and is dedicated to Béla Fleck and his impeccable craft and skill. This is the first movement of a planned three-movement banjo quartet.
Dynamical control of two-level system's decay and long time freezing
Creators: name: Zhang, Wenxian
name: Zhuang, Jun
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We investigate with exact numerical calculation coherent control of a two-level quantum system's decay by subjecting the two-level system to many periodic ideal $2π$ phase modulation pulses. For three spectrum intensities (Gaussian, Lorentzian, and exponential), we find both suppression and acceleration of the decay of the two-level system, depending on difference between the spectrum peak position and the eigen frequency of the two-level system. Most interestingly, the decay of the two-level system freezes after many control pulses if the pulse delay is short. The decay freezing value is half of the decay in the first pulse delay.
description: 6 pages, 6 figures, published in Phys. Rev. A
Fanfare for the Common Good (for Brass Ensemble)--FULL SCORE
Creators: name: Elia, Anthony J.
Publisher: name: Columbia University
Year: 2013
Subjects: Music

description: This was one of various works for brass ensemble, inspired by a community band ensemble in Lawrence, Kansas. This evening concert was attended by the composer in late June 2013, and performed works, which included selections from Giuseppe Verdi's Nabucco. The "Fanfare for the Common Good" is a work dedicated to human good, progress, and community. It is arranged for 2 horns, B-flat Trumpet, B-flat Cornet, and Trombone. Tempi at discretion of conductor.
Heartland: for Brass Ensemble (CORNET)
Creators: name: Elia, Anthony J.
Publisher: name: Columbia University
Year: 2013
Subjects: Music

description: "Heartland" is another work for brass ensemble inspired by the community band performance attended by the composer in Lawrence, Kansas in late June 2013. This work is scored for 2 horns, B-flat trumpet, B-flat cornet, trombone, and Tuba in F. The work is of a more moderate to slow tempo, but can be up to the discretion of the conductor.
The Short History and Long Future of Human Rights Documentation: A Tale of Three Archives
Creators: name: Graham, Pamela M.
Publisher: name: Columbia University
Year: 2012
Subjects: Library science
Information science

description: Libraries have long supported original research in the humanities and social sciences by making physical collections and databases available to scholars. Today, research practices are changing radically. With more news, archives, government information, and other primary materials available in digital form, computer-assisted mining and analysis of large bodies of text and immense corpora of historical data are becoming commonplace. These changes will have an impact on the types of collections libraries build and the types of services and databases they provide for researchers. This presentation showcases the Brasil Nunca Mais project, Human Rights NGO Archives, and the Human Rights Web Archive.
From Lyapunov modes to the exponents for hard disk systems
Creators: name: Chung, Tony
name: Truant, Daniel
name: Morriss, Gary P.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: We demonstrate the preservation of the Lyapunov modes by the underlying tangent space dynamics of hard disks. This result is exact for the zero modes and correct to order $ε$ for the transverse and LP modes where $ε$ is linear in the mode number. For sufficiently large mode numbers the dynamics no longer preserves the mode structure. We propose a Gram-Schmidt procedure based on orthogonality with respect to the centre space that determines the values of the Lyapunov exponents for the modes. This assumes a detailed knowledge of the modes, but from that predicts the values of the exponents from the modes. Thus the modes and the exponents contain the same information.
Spitzer View of Young Massive Stars in the LMC HII Complex N44
Creators: name: Chen, C. -H. Rosie
name: Chu, You-Hua
name: Gruendl, Robert A.
name: Gordon, Karl D.
name: Heitsch, Fabian
Publisher: name: arXiv
Year: 2009
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The HII complex N44 in the Large Magellanic Cloud (LMC) provides an excellent site to perform a detailed study of star formation in a mild starburst, as it hosts three regions of star formation at different evolutionary stages and it is not as complicated and confusing as the 30 Doradus giant HII region. We have obtained Spitzer Space Telescope observations and complementary ground-based 4m uBVIJK observations of N44 to identify candidate massive young stellar objects (YSOs). We further classify the YSOs into Types I, II, and III, according to their spectral energy distributions (SEDs). In our sample of 60 YSO candidates, ~65% of them are resolved into multiple components or extended sources in high-resolution ground-based images. We have modeled the SEDs of 36 YSOs that appear single or dominant within a group. We find good fits for Types I and I/II YSOs,but Types II and II/III YSOs show deviations between their observed SEDs and models that do not include PAH emission. We have also found that some Type III YSOs have central holes in their disk components. YSO counterparts are found in four ultracompact HII regions and their stellar masses determined from SED model fits agree well with those estimated from the ionization requirements of the HII regions. The distribution of YSOs is compared with those of the underlying stellar population and interstellar gas conditions to illustrate a correlation between the current formation of O-type stars and previous formation of massive stars. Evidence of triggered star formation is also presented.
description: 63 pages, 15 figures, accepted for publication for ApJ; some figures in jpeg format to meet the size limit; preprint with high resolution images can be found at http://www.astro.virginia.edu/~cc5ye/n44yso.pdf
Digital landscapes as metaphorical spaces
Creators: name: Greenwood, R
Publisher: name: University Of Tasmania
Year: 2023

description: This project investigated the ways in which new technologies impact on our relationship to the landscape, and the metaphorical possibilities of boundary zones in the landscape; those found between the city and the wilderness. These zones encompass a convergence of different realms of experience; landscapes we inhabit, landscape we have passed through to get here, and the changes we have imposed in the process. In the postmodern world, modern technologies of travel and communication have shrunk the globe and population movement has increased dramatically. In defining self-identity, notions of place are no longer necessarily a dominant factor. This is the broad context of this research project, addressed in terms of my personal experience of migration and through theoretical and historical comparisons. Issues related to migration are epitomised by the experience of John Glover, and how his experience is reflected by his paintings. As an artist originating from England and dealing with pastoral themes I compare my response to his. I contextualise my images with those of contemporary Australian artists whose work addresses shifting boundaries and multiple perspectives in landscape, or whose work involves new technologies. Artists who use a horizontal or panoramic format to convey specific readings of landscape have been of particular importance and inspiration in the development of my images. The major body of images consists of fourteen large-scale computer inkjet prints, on translucent and transparent polyester paper and white glossy paper. They are based on local landscapes: 'natural' bush, urban reserves, farmland and parks. The artworks are derived from video. Colour, scale and form have been digitally altered. The artworks can be layered and illuminated in the gallery to manipulate the viewer's perspective and promote a sense of movement through rhythm and sequence. The artworks are intended to challenge traditionally fixed views of landscape, through the use of digital manipulation, to create generic and symbolic landscape images. The artworks emphasise transitory perspectives that characterise contemporary experience.
Influence of Local and Residual Structures on the Scaling Behavior and Dimensions of Unfolded Proteins
Creators: name: Wang, Zhisong
name: Plaxco, Kevin W.
name: Makarov, Dmitrii E.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: Although recent spectroscopic studies of chemically denatured proteins hint at significant nonrandom residual structure, the results of extensive small angle X-ray scattering studies suggest random coil behavior, calling for a coherent understanding of these seemingly contradicting observations. Here, we report the results of a Monte Carlo study of the effects of two types of local structures, a helix and Polyproline II (PPII) helix, on the dimensions of random coil polyalanine chains viewed as a model of highly denatured proteins. With an alpha helix content of 20%, corresponding to the Ramachandran probability of being in the helical basin, experimentally observed radii of gyration are recovered. Experimental radii are similarly recovered at an a helix content of 87%, providing an explanation for the previously puzzling experimental finding that the dimensions of the highly helical methanol-induced unfolded state are experimentally indistinguishable from those of the helix-poor urea-unfolded state. In contrast, the radius of gyration increases monotonically with increasing PPII content, and is always more expanded than the dimensions observed experimentally. These results suggest that PPII is unlikely the sole, dominant preferred conformation for unfolded proteins.
description: 6 figures
Analog-Domain Security Primitives for Internet-of-Things
Creators: name: Shylendra, Ahish
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: Uncategorized

description: In recent years, internet of things (IoT) has made tremendous progress and continues to evolve to create an ever more connected world by coalescing technology and human interaction. However, since IoT edge devices are often operated in unattended, hostile environments, they are significantly vulnerable to malicious attacks such as counterfeit IC usage, side-channel, and perception attacks. Moreover, severe resource constraints (limited energy, form factor, storage, bandwidth, computational resources) of edge-devices makes detection of such malicious attacks challenging. This thesis defense presents resource efficient CMOS analog/mixed-signal solutions to secure IoT edge devices. At first, to detect use of counterfeit ICs, an intrinsic and database-free IC authentication approach using an analog-to-digital converter (ADC) is presented. In this approach, since ADC is used for data-conversion as well as authentication, energy/area efficiency is improved by avoiding dedicated authentication modules. Next, this work presents co-design of low-power/area CMOS mixed-signal frameworks with statistical modeling methods for on-the-edge, real-time, perception attack and side-channel attack detection. Adopted statistical modeling approaches include non-parametric kernel density estimation (KDE) and parametric harmonic-mean of Gaussian-like Mixture Modeling (HMGM). Unlike neural network-based approaches, statistical modeling-based approaches are computationally light-weight and can be easily updated, hence, enables low latency, energy efficient and highly accurate attack detection. Subsequently, on-silicon implementation of kernel density approach using TSMC 65nm technology is discussed for fast statistical feature extraction from time-domain signals. Proposed feature-extraction approach is co-designed with deep-learning model for anomaly detection in time-series signals.
Additional file 2 of Genetic risk factors for autoimmune hepatitis: implications for phenotypic heterogeneity and biomarkers for drug response
Creators: name: Higuchi, Takashi
name: Shomi Oka
name: Furukawa, Hiroshi
name: Tohma, Shigeto
name: Yatsuhashi, Hiroshi
name: Migita, Kiyoshi
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 2: Supplementary Table 2. Logistic regression analysis of DPB1 alleles in AIH patients with cirrhosis and controls.
Salute: for Brass Ensemble (Bb CORNET)
Creators: name: Elia, Anthony J.
Publisher: name: Columbia University
Year: 2013
Subjects: Music

description: This work, titled "Salute," is scored for seven parts/instruments, and is among the works for brass ensemble inspired by the composer's trip to Lawrence, Kansas in late June 2013, where he attended an evening community concert in the downtown park. The seven parts include 2 horns, Piccolo Trumpet (A), Bb Trumpet, Bb Cornet, Trombone, and Bb Tuba. Tempi at discretion of conductor.
A remark on the Hard Lefschetz Theorem for Kähler orbifolds
Creators: name: Wang, Z. Z.
name: Zaffran, D.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Complex Variables (math.CV)
subject: FOS: Mathematics
subject: 14F25; 53C12

description: We give a proof of the hard Lefschetz theorem for orbifolds that does not involve intersection homology. This answers a question of Fulton. We use a foliated version of the hard Lefschetz theorem due to El Kacimi.
Additional file 1 of Prevalence of metabolic syndrome among breast cancer survivors in East Coast of Peninsular Malaysia
Creators: name: Shahril, Mohd Razif
name: Amirfaiz, Syed
name: Lua, Pei Lin
name: Nurnazahiah, Ali
name: Nor Syamimi Zakarai
name: Ving Lok Kow
name: Ahmad, Aryati
name: Suhaina Sulaiman
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: 60506 Virology
subject: Computational Biology

description: Additional file 1: Supplementary Material Table 1. Relationship between characteristics of breast cancer survivors and metabolic syndrome.
Cosmological Constraints from calibrated Yonetoku and Amati relation implies Fundamental plane of Gamma-ray bursts
Creators: name: Tsutsui, Ryo
name: Nakamura, Takashi
name: Yonetoku, Daisuke
name: Murakami, Toshio
name: Kodama, Yoshiki
name: Takahashi, Keitaro
Publisher: name: arXiv
Year: 2008
Subjects: subject: Astrophysics (astro-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We consider two empirical relations using data only from the prompt emission of Gamma-Ray Bursts (GRBs), peak energy ($E_p$) - peak luminosity ($L_p$) relation (so called Yonetoku relation) and $E_p$-isotropic energy ($E_{\rm iso}$) relation (so called Amati relation). We first suggest the independence of the two relations although they have been considered similar and dependent. From this viewpoint, we compare constraints on cosmological parameters, $Ω_m$ and $Ω_Λ$, from the Yonetoku and Amati relations calibrated by low-redshift GRBs with $z < 1.8$. We found that they are different in 1-$σ$ level, although they are still consistent in 2-$σ$ level. This and the fact that both Amati and Yonetoku relations have systematic errors larger than statistical errors suggest the existence of a hidden parameter of GRBs. We introduce the luminosity time $T_L$ defined by $T_L\equiv E_{\rm iso}/L_p$ as a hidden parameter to obtain a generalized Yonetoku relation as $(L_p/{10^{52} \rm{erg s^{-1}}}) = 10^{-3.88\pm0.09}(E_p/{\rm{keV}})^{1.84\pm0.04} (T_L/{\rm{s}})^{-0.34\pm0.04}$. The new relation has much smaller systematic error, 30%, and can be regarded as "Fundamental plane" of GRBs. We show a possible radiation model for this new relation. Finally we apply the new relation for high-redshift GRBs with $1.8 < z < 5.6$ to obtain $(Ω_m,Ω_Λ) = (0.16^{+0.04}_{-0.06},1.20^{+0.03}_{-0.09})$, which is consistent with the concordance cosmological model within 2-$σ$ level.
description: 5 pages, 6 figures, published in JCAP
Additional file 1 of Implementing an intrapartum package of interventions to improve quality of care to reduce the burden of preterm birth in Kenya and Uganda
Creators: name: Namazzi, Gertrude
name: Achola, Kevin Abidha
name: Jenny, Alisa
name: Santos, Nicole
name: Butrick, Elizabeth
name: Phelgona Otieno
name: Waiswa, Peter
name: Walker, Dilys
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Additional file 1: Supplemental Table 1. The TIDieR (Template for Intervention Description and Replication) Checklist
Assessing through Interviews the Data Management Behaviors and Needs of an Earth and Environmental Sciences Academic Department
Creators: name: Wang, Ting
name: Simboli, Brian
Publisher: name: Columbia University
Year: 2013
Subjects: Information science

description: A post-doctoral CLIR fellow, Ting Wang, has been investigating the data management (DM) and curation behaviors and needs of faculty members in Lehigh University's Earth and Environmental Sciences (EES) department. Many EES faculty members have participated in detailed interviews as part of this investigation. The interviews have revealed a variety of data-related challenges. Some can be readily addressed by Lehigh's Library and Technology Services, while others pose new challenges. The interviewing process provides a model for similar initiatives at other university earth science programs, as well as a potential model for exploring data needs in other research venues and subject areas.
title:  Nostalgia for Fathers: Fatherly Figures in Contemporary Italian Cinema
Creators: name: Tucci, Nausica
Publisher: name: Roma Tre University
publisherIdentifier: https://ror.org/05vf0dg29
publisherIdentifierScheme: ROR
Year: 2025

description: The essay aims to highlight the ability of contemporary Italian cinema to give shape to an unconscious and collective nostalgia, that is the nostalgia of the fathers. A psychological approach shows how it is in the wake of the lack of the father that Italian cinema gives us icastic images of the process of differentiation of the child’s desire that, although can affect different mo- ments of the biological life of the individual, represents the transition from childhood to adulthood. By retracing some recent works and analyzing the father figure in relation to the role he has in the son’s life, the essay aims to bring to light the different outcomes of such process of differentiation in relation to the cinematographic structures that can narrate it (the tragic and comic-romance models, the serial structure).*

Il saggio intende mettere in luce la capacità del cinema italiano contemporaneo di dare forma a una nostalgia inconscia e collettiva, ovvero la nostalgia dei padri. Un approccio psicanalitico mostra come sia sulla scia della mancanza del padre che il cinema italiano ci consegna immagini icastiche del processo di differenziazione del desiderio infantile che, pur potendo interessare momenti diversi della vita biologica dell’individuo, rappresenta il passaggio dall’infanzia all’età adulta. Ripercorrendo alcune opere recenti e analizzando la figura del padre in relazione al ruolo che ha nella vita del figlio, il saggio intende mettere in luce i diversi esiti di tale processo di differenziazione in relazione alle strutture cinematografiche che possono raccontarlo (i modelli tragico e comico-romantico, la struttura seriale).
description: IMAGO. Studi di cinema e media. Nuova serie – Vol. 29
Data Information Literacy: Multiple Paths to a Single Goal
Creators: name: Wright, Sarah J.
name: Carlson, Jake
name: Westra, Brian
name: Jeffryes, Jon
Publisher: name: Columbia University
Year: 2013
Subjects: Information science

description: The Institute of Museum and Library Services funded a two-year project for five teams (each made up of two librarians, one of whom specialized in data services, and a faculty researcher) from four institutions (Purdue University, University of Oregon, University of Minnesota, and Cornell University) to examine the data information literacy needs of graduate student researchers. After identifying the needs of their audience each team developed a tailored approach to bring instruction to their respective graduate students. The involvement of a faculty researcher in each team and pre-instruction interviews of graduate students ensured that the program developed was indeed relevant to researchers' real world data needs. This poster will outline the learning outcomes identified and highlight the instructional approaches taken by the teams. Attendees will learn which data management skills span across the science disciplines and learn of unique needs encountered by researchers in the subjects of Natural Resources, Civil Engineering, Ecology, Electrical and Computer Engineering, and Agricultural and Biological Engineering. The description of the variety of instructional programs will also provide an assortment of options for attendees to take back to their home institutions.
Discrete Self-Similarity in Type-II Strong Explosions
Creators: name: Oren, Yonatan
name: Sari, Re'em
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present new solutions to the strong explosion problem in a non-power law density profile. The unperturbed self-similar solutions discovered by Waxman & Shvarts describe strong Newtonian shocks propagating into a cold gas with a density profile falling off as $r^{-ω}$, where $ω>3$ (Type-II solutions). The perturbations we consider are spherically symmetric and log-periodic with respect to the radius. While the unperturbed solutions are continuously self-similar, the log-periodicity of the density perturbations leads to a discrete self-similarity of the perturbations, i.e. the solution repeats itself up to a scaling at discrete time intervals. We discuss these solutions and verify them against numerical integrations of the time dependent hydrodynamic equations. Finally we show that this method can be generalized to treat any small, spherically symmetric density perturbation by employing Fourier decomposition.
Building The Future: Leveraging Facilities Projects as Platforms for Organizational Change
Creators: name: Cartolano, Robert T.
name: Jaggars, Damon E.
name: Lancaster, Jeffrey R.
name: Rockenbach, Barbara A.
Publisher: name: Columbia University
Year: 2013
Subjects: Library science
Management
Organizational behavior

description: Discipline-based digital centers were implemented to support emergent research methodologies, integrated with expertise from librarians and technologists, and information resources. Planning for the facilities and service programs was driven by extensive assessment of user needs. Panelists will discuss the creation of the digital centers as platforms for implementing organizational change within a research library setting from four distinct perspectives: strategic planning and institutional alignment, operational change management, an evolving workforce, and technological innovation and infrastructure.
The Influence of Hip OA Associated Gait Impairments on Efficiency of Gait and A Possible Rehabilitation
Creators: name: Huang, Chun-Hao
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: Uncategorized

description: Gait impairment may contribute to reduced physical activity in hip osteoarthritis. Abnormal disease-related gait patterns could lead to higher energy expenditure during gait. The consequence of the greater energy used during walking due to gait impairment may contribute to reduce physical activity. However, the mechanism of how abnormal disease-related gait patterns lead to higher energy expenditure during gait and possible rehabilitation strategy in people with hip osteoarthritis is still unclear. To test the hypothesis that step length asymmetry is a modifiable factor associated with gait inefficiency, kinematic, and kinetic deviation in older adults with hip osteoarthritis, Gait analysis, oxygen consumption testing during walking, and split-belt treadmill training were conducted with women with unilateral hip osteoarthritis. Data were analyzed using Spearman correlation, linear regression models, and Repeated measures ANOVA. The results showed that the participants with hip osteoarthritis who demonstrated a greater step length asymmetry presented with lower sagittal plane hip range of motion during gait. Increased step length asymmetry was associated with lower mechanical energy exchange in people with hip osteoarthritis. In addition, more mechanical energy exchange was associated with lower O2 cost during gait. Moreover, Step length asymmetry and O2 rate significantly decreased, while mechanical energy exchange increased after split-belt treadmill training. Reduction of step length asymmetry was significantly associated with reduction of O2 rate. These results suggest that modifying step length asymmetry could enhance metabolic gait efficiency indirectly by improving mechanical energy exchange in women with hip osteoarthritis. This is important because metabolic gait inefficiency contributes to reducing daily physical activity to conserve energy.
Additional file 2 of Implementing an intrapartum package of interventions to improve quality of care to reduce the burden of preterm birth in Kenya and Uganda
Creators: name: Namazzi, Gertrude
name: Achola, Kevin Abidha
name: Jenny, Alisa
name: Santos, Nicole
name: Butrick, Elizabeth
name: Phelgona Otieno
name: Waiswa, Peter
name: Walker, Dilys
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Additional file 2: Supplementary Table 2 Equipment and Supplies Provided by Country