Additional file 1 of The effect of disease misclassification on the ability to detect a gene-environment interaction: implications of the specificity of case definitions for research on Gulf War illness
Creators: name: Haley, Robert W.
name: Dever, Jill A.
name: Kramer, Gerald
name: Teiber, John F.
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Table S1. Description and comparison of the three most commonly used case definitions of Gulf War illness. Table S2. Comparison of symptom measures used by the 3 case definitions to define GWI. Figure S1. An unrotated scree plot (top) and a second one after varimax rotation (bottom) generated by the principal components factor analysis of the 52 symptom scales from the 249 Gulf War veterans in the Developmental Sample. Figure S2. Distributions of the deployed Gulf War veterans on each of the 6 syndrome factor scales from the original Developmental study in the Naval Reserve Battalion and the 2 validation samples. Table S3. Goodness-of-fit validation statistics for structural equation model of Gulf War illness with 3 first-order factors (syndrome variants) and a second-order factor (overall Gulf War illness),a by study and sample within study. Table S4. Demographic and military characteristics of the deployed population and the controls and GWI cases by the various definitions and their overlap. Figure S3. Mean (SEM) SF-12 Mental and Physical Component Scores by GWI case definition in 6,497 deployed veterans. Table S5. Mean SF-12 Mental and Physical Component Scores by GWI case definitions measured in 6,497 deployed Gulf War veterans. Table S6. The association of having heard nerve agent alarms in the Gulf War with the various case definitions of Gulf War illness and their overlap, estimated by unweighted logistic regression in the full deployed USMHS sample, adjusted for the confounding variables age, sex, service branch, rank, active duty vs Guard/Reserve, special strata, and combat exposure scale (numerical values for Figure 3). Table S7. Percentage distribution of the PON1 Q192R genotype in the unaffected controls and groups of  cases defined by the alternative GWI case definitions in the genetics subsample of the USMHS (numerical values for Figure 4). Table S8. Interaction on the additive and multiplicative scales of hearing nerve agent alarms and PON1 Q192R genotype on GWI by the original Research case definition. Table S9. Interaction on the additive and multiplicative scales of hearing nerve agent alarms and PON1 Q192R genotype on GWI by the Research Variant 1 case definition. Table S10. Interaction on the additive and multiplicative scales of hearing nerve agent alarms and PON1 Q192R genotype on GWI by the Research Variant 2 case definition. Table S11. Interaction on the additive and multiplicative scales of hearing nerve agent alarms and PON1 Q192R genotype on GWI by the Research Variant 3 case definition. Table S12. Interaction on the additive and multiplicative scales of hearing nerve agent alarms and PON1 Q192R genotype on GWI by the CDC case definition. Table S13. Interaction on the additive and multiplicative scales of hearing nerve agent alarms and PON1 Q192R genotype on GWI by the CDC mild-to-moderate case definition. Table S14. Interaction on the additive and multiplicative scales of hearing nerve agent alarms and PON1 Q192R genotype on GWI by the CDC Severe case definition. Table S15. Interaction on the additive and multiplicative scales of hearing nerve agent alarms and PON1 Q192R genotype on GWI by the Modified Kansas without exclusions case definition. Table S16. Interaction on the additive and multiplicative scales of hearing nerve agent alarms and PON1 Q192R genotype on GWI by the Modified Kansas with exclusions case definition. Table S17. Interaction on the additive and multiplicative scales of hearing nerve agent alarms and PON1 Q192R genotype on GWI by the CDC case definition excluding those meeting the Research case definition. Table S18. Interaction on the additive and multiplicative scales of hearing nerve agent alarms and PON1 Q192R genotype on GWI by the CDC mild-to-moderate case definition excluding those meeting the Research case definition. Table S19. Interaction on the additive and multiplicative scales of hearing nerve agent alarms and PON1 Q192R genotype on GWI by the CDC Severe case definition excluding those meeting the Research case definition. Table S20. Interaction on the additive and multiplicative scales of hearing nerve agent alarms and PON1 Q192R genotype on GWI by the Modified Kansas with no exclusions case definition excluding those meeting the Research case definition. Table S21. Interaction on the additive and multiplicative scales of hearing nerve agent alarms and PON1 Q192R genotype on GWI by the Modified Kansas with exclusions case definition excluding those meeting the Research case definition. Table S22. Test for heterogeneity of the GxE interaction over age groups, by GWI case definition controlling for confounding. Table S23. Test for heterogeneity of the GxE interaction over sex, by GWI case definition controlling for confounding. Table S24. Estimation of sensitivity and specificity of GWI case definitions.