cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Increased Circulating Osteoprotegerin Levels in Type 1 Diabetes Mellitus: A Systematic Review and Meta-analysis Based on Observational Studies
Creators: name: Chun-Cui Duan
name: Chengcheng Ma
name: Tang, Hai-Qin
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Objectives: Type 1 diabetes mellitus (T1D) has been disclosed to be associated with an elevated risk of cardiovascular disease (CVD), as well as increased risks of losing bone mass and progression of osteoporosis (OP). Osteoprotegerin (OPG), as a decoy receptor, has been demonstrated to play a critical role in bone metabolism homeostasis and vascular atherosclerotic diseases. This meta-analysis aimed to investigate the associations between OPG levels and T1D. Methods: Related literatures were searched and identified from the database of the Cochrane Library database, PubMed and EMbase inception to August 3, 2019 in English. The pooled standard mean difference (SMD) with its 95% confidence interval (CI) was calculated in using random-effect model analysis. Chi-square Q statistic and I2 test were performed to evaluate and quantified the presence of heterogeneity. Results: Twelve studies with 1288 subjects (794 T1D patients and 494 healthy controls) were finally included. The incorporated results indicated that T1D patients have higher plasma/serum OPG levels than in healthy individuals (SMD = 0.64, 95% CI: 0.06, 1.22). Subgroup analyses suggested that Caucasian and glycosylated hemoglobin A1c (HbA1c) <8.5% groups showed higher OPG levels, however, there was no significant differences of OPG levels regarding subgroups of BMI ≥ or <25, children-adolescents or adults and HbA1c ≥8.5%. Conclusions: The current evidence suggested that circulating OPG levels are significantly higher in T1D than in healthy controls, and the increase of OPG levels are influenced by factors of race and HbA1c.
35 Jahre Fotografie für die Archäologische Denkmalpflege Freiburg
Creators: name: Fingerlin, Gerhard
name: Fingerlin, Ilse
Publisher: name: Archäologische Nachrichten aus Baden
Year: 2021

description: Archäologische Nachrichten aus Baden, Bd. 72/73 (2006): Archäologische Nachrichten aus Baden
Jamming transition of a granular pile below the angle of repose
Creators: name: Deboeuf, S.
name: Bertin, E. M.
name: Lajeunesse, E.
name: Dauchot, O.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: We study experimentally the relaxation towards mechanical equilibrium of a granular pile which has just experienced an avalanche and discuss it in the more general context of the granular jamming transition. Two coexisting dynamics are observed in the surface layer: a short time exponential decay consisting in rapid and independent moves of grains and intermittent bursts consisting in spatially correlated moves lasting for longer time. The competition of both dynamics results in long-lived intermittent transients, the total duration of which can late more than a thousand of seconds. We measure a two-time relaxation function, and relate it via a simple statistical model to a more usual two-time correlation function which exhibits strong similarities with auto-correlation functions found in aging systems. Localized perturbation experiments also allow us to test the pile surface layer receptivity.
description: 9 pages, 10 figures
Spontaneous Hawking radiation and beyond: Observing the time evolution of an analogue black hole
Creators: name: Kolobov, Victor I.
name: Golubkov, Katrine
name: de Nova, Juan Ramón Muñoz
name: Steinhauer, Jeff
Publisher: name: arXiv
Year: 2019
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We observe the time dependence of the Hawking radiation in an analogue black hole. Soon after the formation of the horizon, there is little or no Hawking radiation. The Hawking radiation then ramps up during approximately one period of oscillation, until it reaches the quantity expected for spontaneous emission. This is similar to a black hole created from gravitational collapse. The spectrum remains approximately constant at the spontaneous level for some time, similar to a stationary black hole. An inner horizon then forms, in analogy with a charged black hole. The inner horizon causes stimulated Hawking radiation. Both types of stimulation predicted by Ted Jacobson and coworkers likely contribute, but the monochromatic stimulation probably contributes more than does the black-hole lasing.
Overview of Researches on Rural Industrial Development in China’s New Socialist Countryside Construction
Creators: name: Peng, Jie-Wu
name: Peng, Jie-Wu
Publisher: name: Unknown
Year: 2012
Subjects: subject: Agribusiness
subject: New socialist countryside construction
subject: Rural industrial development
subject: Overview

description: From the perspective of rural industrial development, this paper summed up representative research results of China’s new countryside construction, including approval of criteria for classification of rural industrial structure, definition and scope of rural industrial development, introduction and application of industrial development theory, existing problems, causes and countermeasures of three times of industrial development in rural areas, and experience of foreign rural industrial development model. Among these researches, most researches are general and narrow about achievements in rural industrial development, while the causes are little touched upon. In future, it is expected that the research on rural industrial development in new socialist countryside construction will be deepened and specified.
Protein degradation by human 20S proteasomes elucidates the interplay between peptide hydrolysis and splicing.
Creators: name: Soh, Wai Tuck
name: Roetschke, Hanna P
name: Cormican, John A
name: Teo, Bei Fang
name: Chiam, Nyet Cheng
name: Raabe, Monika
name: Pflanz, Ralf
name: Henneberg, Fabian
name: Becker, Stefan
name: Chari, Ashwin
name: Liu, Haiyan
name: Urlaub, Henning
name: Liepe, Juliane
name: Mishto, Michele
Publisher: name: The Francis Crick Institute
Year: 2024
Subjects: classificationCode: Biochemistry & Proteomics
subject: Biochemistry & Proteomics
classificationCode: Immunology
subject: Immunology
subject: FOS: Clinical medicine
classificationCode: Tumour Biology
subject: Tumour Biology

description: If and how proteasomes catalyze not only peptide hydrolysis but also peptide splicing is an open question that has divided the scientific community. The debate has so far been based on immunopeptidomics, in vitro digestions of synthetic polypeptides as well as ex vivo and in vivo experiments, which could only indirectly describe proteasome-catalyzed peptide splicing of full-length proteins. Here we develop a workflow-and cognate software - to analyze proteasome-generated non-spliced and spliced peptides produced from entire proteins and apply it to in vitro digestions of 15 proteins, including well-known intrinsically disordered proteins such as human tau and α-Synuclein. The results confirm that 20S proteasomes produce a sizeable variety of cis-spliced peptides, whereas trans-spliced peptides are a minority. Both peptide hydrolysis and splicing produce peptides with well-defined characteristics, which hint toward an intricate regulation of both catalytic activities. At protein level, both non-spliced and spliced peptides are not randomly localized within protein sequences, but rather concentrated in hotspots of peptide products, in part driven by protein sequence motifs and proteasomal preferences. At sequence level, the different peptide sequence preference of peptide hydrolysis and peptide splicing suggests a competition between the two catalytic activities of 20S proteasomes during protein degradation.
Vom städtischen Wohnhaus zum Jesuitenkolleg - Baugeschichtliche Beobachtungen im Keller der „Alten Universität" in Freiburg
Creators: name: Schoenenberg, Valerie
Publisher: name: Archäologische Nachrichten aus Baden
Year: 2021

description: Archäologische Nachrichten aus Baden, Bd. 72/73 (2006): Archäologische Nachrichten aus Baden
When $\tan β$ meets all the mixing angles
Creators: name: Hernández, Antonio E. Cárcamo
name: Dib, Claudio O.
name: Saldaña-Salazar, Ulises J.
Publisher: name: arXiv
Year: 2020
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Models with two-Higgs-doublets and natural flavour conservation contain $\tan β= v_2 / v_1$ as a physical parameter. We offer here a generalization of a recently proposed idea where only the Cabibbo angle, $θ_\text{c} \simeq 0.22$, was related to $\tan β$ by virtue of the $\mathbb{D}_{4}$ dihedral symmetry group. The original proposal consisted of a massless first generation of quarks and no mixing with the third generation. In our case, through the addition of a third Higgs doublet with a small vacuum-expectation-value but very large masses, thus later decoupling, all quarks become massive and quark mixing is fully reproduced. In fact, all quark mixing angles are expressed in terms of $\tan β$ and one recovers trivial mixing in the limit $β\rightarrow 0$. We also explore the consequences in lepton mixing by adopting a type I seesaw mechanism with three heavy right-handed neutrinos.
description: Major improvement to the overall content of the paper; 15 pages, 8 figures, new sections, appendices and references; Matches published version in PLB
Effect of Class Switch Recombination Defect on the Phenotype of Ataxia-Telangiectasia Patients
Creators: name: Amirifar, Parisa
name: Mozdarani, Hossein
name: Yazdani, Reza
name: Kiaei, Fatemeh
name: Tannaz Moeini Shad
name: Shahkarami, Sepideh
name: Abolhassani, Hassan
name: Samaneh Delavari
name: Sohani, Mahsa
name: Arezou Rezaei
name: Gholamreza Hassanpour
name: Akrami, Seyed Mohammad
name: Aghamohammadi, Asghar
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Objectives: Ataxia-telangiectasia (A-T) is an autosomal recessive neurodegenerative disorder with multisystem involvement caused by homozygous or compound heterozygous mutations in the ataxia telangiectasia mutated (ATM) gene which encodes a serine/threonine protein kinase. The aims of this study were to investigate class switch recombination (CSR) and to review the clinical and immunologic phenotypes of 3 groups of A-T patients, including A-T patients with CSR defects (CSR-D), A-T patients with selective immunoglobulin A deficiency (IgA-D) and A-T patients with normal Ig level. Methods: In this study, 41 patients with confirmed diagnosis of A-T (16 A-T patients with HIgM, 15 A-T patients with IgA-D, and 10 A-T patients with normal Ig levels) from Iranian immunodeficiency registry center were enrolled. B-cell proliferation, in vitro CSR toward IgE and IgA were compared between three groups as well as G2 radiosensitivity assay. Results: Earliest presentation of telangiectasia was a significant hallmark in A-T patients with CSR-D (p = .036). In this investigation, we found that the frequency of respiratory infection (p = .002), pneumonia (p = .02), otitis media (p = .008), chronic fever (p p = .02) and hepatosplenomegaly (p = .03) in A-T patients with HIgM phenotype were significantly higher than the other groups. As expected IgE production stimulation and IgA CSR were perturbed in HIgM patients that were aligned with the higher readiosenstivity scores in this group. Conclusion: A-T patients with HIgM compared to other A-T patients presenting more infections and noninfectious complications, therefore, early detection and careful management of these patients is necessary.
BSDEs and log-utility maximization for Lévy processes
Creators: name: Di Tella, Paolo
name: Engelbert, Hans-Jürgen
Publisher: name: arXiv
Year: 2019
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: In this paper we establish the existence and the uniqueness of the solution of a special class of BSDEs for Lévy processes in the case of a Lipschitz generator of sublinear growth. We then study a related problem of logarithmic utility maximization of the terminal wealth in the filtration generated by an arbitrary Lévy process.
description: Published at https://doi.org/10.15559/19-VMSTA144 in the Modern Stochastics: Theory and Applications (https://vmsta.org/) by VTeX (http://www.vtex.lt/)
The Realization Path of Japan's Agricultural Modernization and Its Precious Experience for China
Creators: name: Zhang, Xiu-Guang
name: Xie, Ping
name: Zhang, Xiu-Guang
name: Xie, Ping
Publisher: name: Unknown
Year: 2012
Subjects: subject: Agribusiness
subject: Japan
subject: Agricultural modernization
subject: Realization path
subject: Peasant economy

description: In Japan, the per capita arable land area is small, the natural resources are short, and agricultural production has the typical characteristics of the peasant economy. Even if there are many unfavorable conditions, the level of agricultural modernization of Japan has exceeded that of many developed countries. We conduct comparative analysis on the development characteristics of China's agriculture and Japan's agriculture, and summarize the realization path of Japan's agricultural modernization. Based on the reality of China, we can draw on the following experience from Japan: establishing and improving the agricultural legislation for agriculture; improving the rural cooperative economic organizations; deepening the reform of the agricultural land property right system; increasing the government's direct funds input of into agriculture; improving the agricultural technology extension system.
Vom Oberrhein zur jungen Donau: Die Straße durch den südlichen Schwarzwald in keltischer, römischer und frühmittelalterlicher Zeit
Creators: name: Fingerlin, Gerhard
Publisher: name: Archäologische Nachrichten aus Baden
Year: 2021

description: Archäologische Nachrichten aus Baden, Bd. 72/73 (2006): Archäologische Nachrichten aus Baden
MOESM1 of Statin-induced anti-HMGCR myopathy: successful therapeutic strategies for corticosteroid-free remission in 55 patients
Creators: name: Meyer, Alain
name: Troyanov, Yves
name: Drouin, Julie
name: Oligny-Longpré, Geneviève
name: Landon-Cardinal, Océane
name: Hoa, Sabrina
name: Hervier, Baptiste
name: Bourré-Tessier, Josiane
name: Mansour, Anne-Marie
name: Hussein, Sara
name: Morin, Vincent
name: Rich, Eric
name: Jean-Richard Goulet
name: Chartrand, Sandra
name: Hudson, Marie
name: Nehme, Jessica
name: Makhzoum, Jean-Paul
name: Zarka, Farah
name: Villeneuve, Edith
name: Raynauld, Jean-Pierre
name: Landry, Marianne
name: O’Ferrall, Erin
name: Ferreira, Jose
name: Ellezam, Benjamin
name: Karamchandani, Jason
name: Larue, Sandrine
name: Massie, Rami
name: Isabelle, Catherine
name: Deschênes, Isabelle
name: Leclair, Valérie
name: Couture, Hélène
name: Targoff, Ira
name: Fritzler, Marvin
name: Senécal, Jean-Luc
Publisher: name: figshare
Year: 2020
Subjects: subject: Space Science
subject: Molecular Biology
subject: Neuroscience
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: Additional file 1 : Table S1. Definitions for therapy, remission, maintenance and severity of anti-HMGCR myopathy.
Entanglement control of two-level atoms in dissipative cavities
Creators: name: Salah, Reyad
name: Farouk, Ahmed M.
name: Farouk, Ahmed
name: Abdel-Aty, M.
name: Obada, A. -S. F.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: An open quantum bipartite system consisting of two independent two-level atoms interacting non-linearly with a two-mode electromagnetic cavity field is investigated by proposing a suitable non-Hermitian generalization of Hamiltonian. The mathematical procedure of obtaining the corresponding wave function of the system is clearly given. Panchartnam phase is studied to give a precise information about the required initial system state, which is related to artificial phase jumps, to control the Degree of Entanglement (DEM) and get the highest Concurrence. We discuss the effect of time-variation coupling, and dissipation of both atoms and cavity. The effect of the time-variation function appears as frequency modulation (FM) effect in the radio waves. Concurrence rapidly reaches the disentangled state (death of entanglement) by increasing the effect of field decay. On the contrary, the atomic decay has no effect.
description: 5 pages, 9 figures
MOESM1 of A sustainable process for biodiesel production using Zn/Mg oxidic species as active, selective and reusable heterogeneous catalysts
Creators: name: Navas, Marisa
name: Ruggera, José
name: Lick, Ileana
name: Casella, Mónica
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology

description: Additional file 1. Additional figures.
The pre-history of quantum computation
Creators: name: Potgieter, P. H.
Publisher: name: arXiv
Year: 2004
Subjects: subject: General Literature (cs.GL)
subject: FOS: Computer and information sciences
subject: F.1.2

description: The main ideas behind developments in the theory and technology of quantum computation were formulated in the late 1970s and early 1980s by two physicists in the West and a mathematician in the former Soviet Union. It is not generally known in the West that the subject has roots in the Russian technical literature. The author hopes to present as impartial a synthesis as possible of the early history of thought on this subject. The role of reversible and irreversible computational processes is examined briefly as it relates to the origins of quantum computing and the so-called Information Paradox in physics.
description: 11 pages, in Afrikaans (title: Die voorgeskiedenis van kwantumberekening) with English abstract
VMD, chiral loops, sigma-meson, and omega-rho mixing in omega-->pi^0 pi^0 gamma decay
Creators: name: Gokalp, A.
name: Kucukarslan, A.
name: Yilmaz, O.
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In an attempt to explain the latest experimental result about the branching ratio of $ω\to π^0π^0γ$ decay we reexamine the decay mechanism of this decay in a phenomenological framework in which the contributions of VMD, chiral loops, $σ$-meson intermediate state amplitudes and the effects of $ω-ρ$ mixing are considered. We conclude that in order to obtain the experimental value of the branching ratio $B(ω\to π^0π^0γ)$ $σ$-meson amplitude which makes a substantial contribution should be included into the reaction mechanism and the effects of $ω-ρ$ mixing should be taken into account. We also estimate the coupling constant $g_{ωσγ}$ as $g_{ωσγ}=0.11$ which is much smaller than the values suggested by light cone QCD sum rules calculations.
description: to be published in Phys. Rev. D
How to orient cells in micro-cavities for high resolution imaging of cytokinesis and lumen formation
Creators: name: Bhat, Alka
name: Lu, Linjie
name: Wang, Chen-Ho
name: Vecchio, Simon Lo
name: Maraspini, Riccardo
name: Honigmann, Alf
name: Riveline, Daniel
Publisher: name: arXiv
Year: 2019
Subjects: subject: Quantitative Methods (q-bio.QM)
subject: Image and Video Processing (eess.IV)
subject: FOS: Biological sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Imaging dynamics of cellular morphogenesis with high spatial-temporal resolution in 3D is challenging, due to the low spatial resolution along the optical axis and photo-toxicity. However, some cellular structures are planar and hence 2D imaging should be sufficient, provided that the structure of interest can be oriented with respect to the optical axis of the microscope. Here, we report a 3D microfabrication method which positions and orients cell divisions very close to the microscope coverglass. We use this approach to study cytokinesis in fission yeasts and polarization to lumen formation in mammalian epithelial cells. We show that this method improves spatial resolution on range of common microscopies, including super-resolution STED. Altogether, this method could shed new lights on self-organization phenomena in single cells and 3D cell culture systems.
RS1, Custodial Isospin and Precision Tests
Creators: name: Agashe, Kaustubh
name: Delgado, Antonio
name: May, Michael J.
name: Sundrum, Raman
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study precision electroweak constraints within a RS1 model with gauge fields and fermions in the bulk. The electroweak gauge symmetry is enhanced to SU(2)_L \times SU(2)_R \times U(1)_{B-L}, thereby providing a custodial isospin symmetry sufficient to suppress excessive contributions to the T parameter. We then construct complete models, complying with all electroweak constraints, for solving the hierarchy problem, without supersymmetry or large hierarchies in the fundamental couplings. Using the AdS/CFT correspondence our models can be interpreted as dual to a strongly coupled conformal Higgs sector with global custodial symmetry, gauge and fermionic matter being fundamental fields external to the CFT. This scenario has interesting collider signals, distinct from other RS models in the literature.
description: 32 pages, 6 figures, latex2e, minor changes, references added
Fundsachen: Ein römischer Spiegel aus einem Brandgrab von Hüfingen/Brigobannis
Creators: name: Fingerlin, Gerhard
Publisher: name: Archäologische Nachrichten aus Baden
Year: 2021

description: Archäologische Nachrichten aus Baden, Bd. 72/73 (2006): Archäologische Nachrichten aus Baden
title: La vitalità dei centri costieri degli Aurunci
Creators: name: Gallo, Alessandro
Publisher: name: Semestrale di studi e ricerche di geografia
Year: 2019

description: L'AGRO PONTINO E TERRACINA Lasciata l'Autostrada Milano-Napoli all'altezza di Frosinone, imboccata la S.S. n. 156 che scavalcando il Fiume Amaseno entra nella Provincia di Latina, notiamo, poco dopo Prossedi, i lavori in atto per la realizzazione di una variante che elimini il passaggio all'interno del centro abitato di Priverno e l' Abbazia di Fossanova.
description: Semestrale di studi e ricerche di geografia, N. 2 (1991)
Linear and Second-order Optical Response from First Principles
Creators: name: Sharma, S.
name: Ambrosch-Draxl, C.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We present a full formalism for the calculation of the linear and second-order optical response for semiconductors and insulators. The expressions for the optical susceptibilities are derived within perturbation theory. As a starting point a brief background of the single and many particle Hamiltonians and operators is provided. As an example we report calculations of the linear and nonlinear optical properties of the mono-layer InP/GaP (110) superlattice. The features in the linear optical spectra are identified to be coming from various band combinations. The main features in the second-order optical spectra are analyzed in terms of resonances of peaks in linear optical spectra. With the help of the strain corrected effective-medium-model the interface selectivity of the second-order optical properties is highlighted.
description: 10 pages 4 figures, conference & physica scripta
Contribution of long-chain fatty acid to induction of myeloid-derived suppressor cell (MDSC)-like cells – induction of MDSC by lipid vesicles (liposome)
Creators: name: Yoshida, Yoichiro
name: Tsunehisa Nagamori
name: Ishibazawa, Emi
name: Kobayashi, Hiroya
name: Kure, Tomoko
name: Sakai, Hiromi
name: Takahashi, Daisuke
name: Fujihara, Mitsuhiro
name: Azuma, Hiroshi
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Hematology
subject: Plant Biology

description: Effects of liposomal particles on immune function have not been adequately investigated. Earlier reports indicate that intravenous injection of rats with pegylated liposomes comprising chemically defined specific lipids produces myeloid derived suppressor-cell (MDSC)-like cells in the spleen. After liposome injection, we sought a cell surface marker expressed specifically on splenic macrophages. Then we assessed the immunosuppressive activity of macrophages positive for the marker. Furthermore, we investigated whether immunosuppression induction is an immunopharmacological action specific to this pegylated liposome, or not. After using a microarray system to screen genes enhanced by this liposome, we evaluated cell surface expression of gene products using flow cytometry. Liposomes of several kinds, each comprising one type of phospholipid, were prepared and evaluated for their ability to induce T-cell suppression. Microarray analysis indicated enhanced B7-H3 expression. Flow cytometry revealed that the B7-H3 molecule was expressed on splenic macrophages after liposome injection. B7-H3+ macrophages were positive for iNOS. Removing B7-H3+ cells restored T-cell proliferation. Similarly to this liposome, various liposomes with different long chain fatty acids induced T-cell suppression when accumulated in the spleen. Immunosuppressive cells induced by this pegylated liposome closely resemble MDSCs, especially B7-H3+ MDSCs. Immunosuppression induction is not a phenomenon specific to this liposome. Accumulation of long chain fatty acid in macrophages by internalization of liposomal nanoparticles might be related to macrophage acquisition of immunosuppressive activity in vivo.
Robust concurrent topology optimization of structure and its composite material considering uncertainty with imprecise probability
Creators: name: Wu, Y.
name: Li, Eric
name: He, Z. C.
name: Lin, X. Y.
name: Jiang, H. X.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Computational Engineering, Finance, and Science (cs.CE)
subject: Optimization and Control (math.OC)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: This paper studied a robust concurrent topology optimization (RCTO) approach to design the structure and its composite materials simultaneously. For the first time, the material uncertainty with imprecise probability is integrated into the multi-scale concurrent topology optimization (CTO) framework. To describe the imprecise probabilistic uncertainty efficiently, the type I hybrid interval random model is adopted. An improved hybrid perturbation analysis (IHPA) method is formulated to estimate the expectation and stand variance of the objective function in the worst case. Combined with the bi-directional evolutionary structural optimization (BESO) framework, the robust designs of the structure and its composite material are carried out. Several 2D and 3D numerical examples are presented to illustrate the effectiveness of the proposed method. The results show that the proposed method has high efficiency and low precision loss. In addition, the proposed RCTO approach remains efficient in both of linear static and dynamic structures, which shows its extensive adaptability.
Contribution of long chain fatty acid to induction of myeloid-derived suppressor cell (MDSC)-like cells – Induction of MDSC by lipid vesicles (liposome) –
Creators: name: Yoshida, Yoichiro
name: Tsunehisa Nagamori
name: Ishibazawa, Emi
name: Kobayashi, Hiroya
name: Kure, Tomoko
name: Sakai, Hiromi
name: Takahashi, Daisuke
name: Fujihara, Mitsuhiro
name: Azuma, Hiroshi
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Hematology

description: Context: Effects of liposomal particles on immune function have not been adequately investigated. Earlier reports indicate that intravenous injection of rats with pegylated liposomes comprising chemically defined specific lipids produces myeloid derived suppressor-cell (MDSC)-like cells in the spleen. Objectives: After liposome injection, we sought a cell surface marker expressed specifically on splenic macrophages. Then we assessed the immunosuppressive activity of macrophages positive for the marker. Furthermore, we investigated whether immunosuppression induction is an immunopharmacological action specific to this pegylated liposome, or not. Materials and Methods: After using a microarray system to screen genes enhanced by this liposome, we evaluated cell surface expression of gene products using flow cytometry. Liposomes of several kinds, each comprising one type of phospholipid, were prepared and evaluated for their ability to induce T-cell suppression. Results: Microarray analysis indicated enhanced B7-H3 expression. Flow cytometry revealed that the B7-H3 molecule was expressed on splenic macrophages after liposome injection. B7-H3+ macrophages were positive for iNOS. Removing B7-H3+ cells restored T-cell proliferation. Similarly to this liposome, various liposomes with different long chain fatty acids induced T-cell suppression when accumulated in the spleen. Conclusions: Immunosuppressive cells induced by this pegylated liposome closely resemble MDSCs, especially B7-H3+ MDSCs. Immunosuppression induction is not a phenomenon specific to this liposome. Accumulation of long chain fatty acid in macrophages by internalization of liposomal nanoparticles might be related to macrophage acquisition of immunosuppressive activity in vivo.
MOESM1 of Genetic characterization of Stargardt clinical phenotype in South Indian patients using sanger and targeted sequencing
Creators: name: Raj, Rajendran
name: Pankaja Dhoble
name: Anjanamurthy, Rupa
name: Chermakani, Prakash
name: Manojkumar Kumaran
name: Bharanidharan Devarajan
name: Periasamy Sundaresan
Publisher: name: figshare
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: 60506 Virology

description: Additional file 1: Table S1. List of non-pathogenic variants identified in STGD patients (ID: 25, 26, 27, 28) by Targeted exome sequencing. Table S2. Segregation analysis of 11 unrelated probands. Segregation analysis was performed for parents of 11 unrelated probands; ß Consanguinity in parents; * Consanguinity in previous generation; # Non consanguinity in parents; † Genetic analysis was performed for affected sibling.
An Immunosuppressive Effect of Melanoma-derived Exosomes on NY-ESO-1 Antigen-specific Human CD8+ T Cells is Dependent on IL-10 and Independent of BRAFV600E Mutation in Melanoma Cell Lines
Creators: name: ShinLa Shu
name: Matsuzaki, Junko
name: Muzamil Y. Want
name: Conway, Alexis
name: Benjamin-Davalos, Shawna
name: Allen, Cheryl L.
name: Koroleva, Marina
name: Battaglia, Sebastiano
name: Adekunle Odunsi
name: Minderman, Hans
name: Ernstoff, Marc S.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Space Science
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: Exosomes, including human melanoma-derived exosomes (HMEX), are known to suppress the function of immune effector cells, which for HMEX has been associated with the surface presence of the immune checkpoint ligand PD-L1. This study investigated the relationship between the BRAF mutational status of melanoma cells and the inhibition of secreted HMEX exosomes on antigen-specific human T cells. Exosomes were isolated from two melanoma cell lines, 2183-Her4 and 888-mel, which are genetically wild-type BRAFWT and BRAFV600E, respectively. HMEX were isolated using a modified, size-exclusion chromatography (SEC) method shown to reduce co-isolation of non-exosome-associated cytokines compared to ultracentrifugation isolation. The immunoinhibitory effect of the exosomes was tested in vitro on patient-derived NY-ESO-1-specific CD8+ T cells challenged with NY-ESO-1 antigen. HMEX from both cell lines inhibited the immune response of antigen-specific T cells comparably, as evidenced by the reduction of IFN-γ and TNF-α in NY-ESO-1 tetramer-positive cells. This inhibition could be partially reversed by the presence of anti-PD-L1 and anti-IL-10 antibodies. IL-10 has been demonstrated to be a critical pathway for sustaining enhanced tumorigenesis in BRAFV600E mutant cells compared to BRAFWT melanoma cells. Thus, we demonstrate that HMEX inhibit antigen-specific T cell responses independent of the BRAF mutational status of the parent cells. In addition, PD-L1 and IL-10 contribute to the HMEX-mediated immunosuppression of antigen-specific human T cells. The inhibitory capacity of exosomes should be taken into consideration when developing therapies that are reliant upon the potency of customized, antigen-specific effector T cells.
MOESM5 of Time is of the essence when treating necrotizing soft tissue infections: a systematic review and meta-analysis
Creators: name: Nawijn, Femke
name: Smeeing, Diederik
name: Houwert, Roderick
name: Leenen, Luke
name: Falco Hietbrink
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 5: Results from quality assessment of articles included in meta-analyses assessing surgical timing in relation to mortality and amputation due to necrotizing soft tissue infections.
MOESM4 of Time is of the essence when treating necrotizing soft tissue infections: a systematic review and meta-analysis
Creators: name: Nawijn, Femke
name: Smeeing, Diederik
name: Houwert, Roderick
name: Leenen, Luke
name: Falco Hietbrink
Publisher: name: figshare
Year: 2020
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 4: Forest plots for all (subgroup) analyses assessing surgical timing in relation to mortality and amputation due to necrotizing soft tissue infections.
Conductivity of thermally fluctuating superconductors in two dimensions
Creators: name: Sachdev, Subir
Publisher: name: arXiv
Year: 2003
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We review recent work on a continuum, classical theory of thermal fluctuations in two dimensional superconductors. A functional integral over a Ginzburg-Landau free energy describes the amplitude and phase fluctuations responsible for the crossover from Gaussian fluctuations of the superconducting order at high temperatures, to the vortex physics of the Kosterlitz-Thouless transition at lower temperatures. Results on the structure of this crossover are presented, including new results for corrections to the Aslamazov-Larkin fluctuation conductivity.
description: 9 pages
Quantum information scrambling in a trapped-ion quantum simulator with tunable range interactions
Creators: name: Joshi, Manoj K.
name: Elben, Andreas
name: Vermersch, Benoît
name: Brydges, Tiff
name: Maier, Christine
name: Zoller, Peter
name: Blatt, Rainer
name: Roos, Christian F.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Quantum Physics (quant-ph)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: In ergodic many-body quantum systems, locally encoded quantum information becomes, in the course of time evolution, inaccessible to local measurements. This concept of "scrambling" is currently of intense research interest, entailing a deep understanding of many-body dynamics such as the processes of chaos and thermalization. Here, we present first experimental demonstrations of quantum information scrambling on a 10-qubit trapped-ion quantum simulator representing a tunable long-range interacting spin system, by estimating out-of-time ordered correlators (OTOCs) through randomized measurements. We also analyze the role of decoherence in our system by comparing our measurements to numerical simulations and by measuring Rényi entanglement entropies.
description: 9 pages and 8 figures
La differenziazione didattica: alcune strategie di differenziazione didattica per favorire l'inclusione nelle classi di scuola elementare
Creators: name: Pini, Giada
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2025
Subjects: differenziazione
inclusione
didattica inclusiva
strategie didattiche

description: Il termine differenziazione didattica viene al giorno d’oggi utilizzato frequentemente nel mondo legato alla formazione. Ma gli insegnanti conoscono veramente il suo significato? Sanno applicare una corretta e funzionale differenziazione all’interno delle proprie classi di scuola elementare? Trattandosi di un metodo educativo atto alla promozione dell’inclusione, riuscire a comprenderne gli aspetti principali, può rivelarsi una buona risorsa per l’apprendimento, nonostante la sua complessità. Infatti, partendo dall’eterogeneità delle abilità e delle conoscenze degli studenti, è possibile esaminare e costruire delle strategie pratiche, per poter adattare l’insegnamento ai bisogni individuali, valorizzando le capacità uniche di ciascuno. Attraverso questa modalità di apprendimento, viene quindi costruito un ambiente inclusivo, che riconosce e supporta le varie differenze individuali, favorendo così un apprendimento efficace e personalizzato, incidendo poi sulla motivazione e sull’autonomia degli studenti. Più nel concreto all’interno di questo lavoro di ricerca documentale vengono esplorati i concetti principali del tema, partendo da alcuni elementi maggiormente teorici, così da avere un quadro completo delle fondamenta di questo approccio educativo. Successivamente viene proposta una panoramica di alcune strategie da poter applicare nella propria classe, seguite poi da alcune riflessioni finali, che permettono un confronto più concreto delle modalità presentate.
MOESM2 of Time is of the essence when treating necrotizing soft tissue infections: a systematic review and meta-analysis
Creators: name: Nawijn, Femke
name: Smeeing, Diederik
name: Houwert, Roderick
name: Leenen, Luke
name: Falco Hietbrink
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 2: Quality assessment tool for systematic review assessing surgical timing in relation to mortality and amputation due to necrotizing soft tissue infections.
Dynamic principal component regression for forecasting functional time series in a group structure
Creators: name: Shang, Han Lin
Publisher: name: arXiv
Year: 2019
Subjects: subject: Applications (stat.AP)
subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences
subject: 97M30, 97K80

description: When generating social policies and pricing annuity at national and subnational levels, it is essential both to forecast mortality accurately and ensure that forecasts at the subnational level add up to the forecasts at the national level. This has motivated recent developments in forecasting functional time series in a group structure, where static principal component analysis is used. In the presence of moderate to strong temporal dependence, static principal component analysis designed for independent and identically distributed functional data may be inadequate. Thus, through using the dynamic functional principal component analysis, we consider a functional time series forecasting method with static and dynamic principal component regression to forecast each series in a group structure. Through using the regional age-specific mortality rates in Japan obtained from the Japanese Mortality Database (2019), we investigate the point and interval forecast accuracies of our proposed extension, and subsequently make recommendations.
description: 19 pages, 7 figures, to appear in Scandinavian Actuarial Journal. arXiv admin note: text overlap with arXiv:1705.08001, arXiv:1609.04222
title: Characterizing sediment dewatering and fluid flow in accretionary systems – A rock magnetic approach on the example of IODP Site U1518
Creators: name: Greve (1), Annika
name: Kars (2), Myriam
name: Deckers (1), Mark J.
name: Stipp (3), Michael
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2020

description: Paleomagnetic Laboratory 'Fort Hoofddijk', Department of Earth Sciences, Utrecht University, Utrecht, The Netherlands (1); Center for Advanced Marine Core Research, Kochi University, Nankoku, Japan (2); Institute of Geosciences and Geography, Martin-Luther University Halle, Halle, Germany (3)

The dewatering and subsequent drainage of fluids from porous sediments in forearc regions control the frictional behavior of the plate boundary décollement and all other faults in the forearc. Site U1518 of International Ocean Discovery Program (IODP) Expedition 375 penetrated the Pāpaku fault, a shallow splay fault near the deformation front of the Hikurangi Subduction Margin (New Zealand). We present rock magnetic datasets that help to depict strain history, and provide information on permeability anisotropy as well as the locus of fluid and gas migration across the fault zone. A set of room temperature magnetic parameters was acquired on one sample per every meter of core recovered. Conspicuous are two anomalies at 304 - 312 m and 334 - 351 m (below seafloor), towards lower remanence intensity and coercivity. The upper interval coincides with an upper strand of high intensity fracturing and deformation within the Pāpaku fault, the lower interval to a sand-rich interval adjacent to a lower strand of high intensity deformation. Backscattered electron images show a significantly higher abundance of, and recrystallization of framboidal iron-sulfide minerals in this zone. We propose that the rock magnetic signature is due to the reduction of ferrimagnetic greigite (Fe3S4) to paramagnetic pyrite (FeS2). This is most likely caused by the drainage of methane-, and sulfide rich fluids/gas along high permeability zones. The results of magnetic fabric analyses conducted using the Anisotropy of Magnetic Susceptibility (AMS) indicate a sub-horizontal near fault-parallel alignment of paramagnetic clay minerals, which may have enhanced permeability anisotropy.
Yukawa couplings in intersecting D-brane models
Creators: name: Cremades, D.
name: Ibanez, L. E.
name: Marchesano, F.
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We compute the Yukawa couplings among chiral fields in toroidal Type II compactifications with wrapping D6-branes intersecting at angles. Those models can yield realistic standard model spectrum living at the intersections. The Yukawa couplings depend both on the Kahler and open string moduli but not on the complex structure. They arise from worldsheet instanton corrections and are found to be given by products of complex Jacobi theta functions with characteristics. The Yukawa couplings for a particular intersecting brane configuration yielding the chiral spectrum of the MSSM are computed as an example. We also show how our methods can be extended to compute Yukawa couplings on certain classes of elliptically fibered CY manifolds which are mirror to complex cones over del Pezzo surfaces. We find that the Yukawa couplings in intersecting D6-brane models have a mathematical interpretation in the context of homological mirror symmetry. In particular, the computation of such Yukawa couplings is related to the construction of Fukaya's category in a generic symplectic manifold.
description: 47 pages, using JHEP3.cls, 11 figures. Typos and other minor corrections. References added
Accelerating Deep Neural Networks for Real-time Data Selection for High-resolution Imaging Particle Detectors
Creators: name: Jwa, Yeon-Jae
name: Di Guglielmo, Giuseppe
name: Carloni, Luca P.
name: Karagiorgi, Georgia
Publisher: name: arXiv
Year: 2022
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: This paper presents the custom implementation, optimization, and performance evaluation of convolutional neural networks on field programmable gate arrays, for the purposes of accelerating deep neural network inference on large, two-dimensional image inputs. The targeted application is that of data selection for high-resolution particle imaging detectors, and in particular liquid argon time projection chamber detectors, such as that employed by the future Deep Underground Neutrino Experiment. We motivate this particular application based on the excellent performance of deep neural networks on classifying simulated raw data from the DUNE LArTPC, combined with the need for power-efficient data processing in the case of remote, long-term, and limited-access operating detector conditions.
description: 10 pages, 5 figures, 8 tables