cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Expression of Cytokeratins 17 and 5 Identifies a Group of Breast Carcinomas with Poor Clinical Outcome
Creators: name: Botstein, David
name: Perou, Charles M.
name: Haas, Phillippe
name: Dieterich, Holger
name: Zuber, Markus
name: Tibshirani, Rob
name: van de Rijn, Matt
name: Mross, Frank
name: Kononen, Juha
name: Seitz, Rob
name: Torhorst, Joachim
name: Ross, Doug
name: Köchli, Ossi R.
name: Brown, Pat
name: Sauter, Guido
name: Kallioniemi, Olli
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: While several prognostic factors have been identified in breast carcinoma, the clinical outcome remains hard to predict for individual patients. Better predictive markers are needed to help guide difficult treatment decisions. In a previous study of 78 breast carcinoma specimens, we noted an association between poor clinical outcome and the expression of cytokeratin 17 and/or cytokeratin 5 mRNAs. Here we describe the results of immunohistochemistry studies using monoclonal antibodies against these markers to analyze more than 600 paraffin-embedded breast tumors in tissue microarrays. We found that expression of cytokeratin 17 and/or cytokeratin 5/6 in tumor cells was associated with a poor clinical outcome. Moreover, multivariate analysis showed that in node-negative breast carcinoma, expression of these cytokeratins was a prognostic factor independent of tumor size and tumor grade.
Lately Exposed Amorphous Water Ice on Comet 49P/Arend-Rigaux
Creators: name: Sivaraman, B.
name: Venkataraman, V.
name: Kalyaan, A.
name: Arora, S.
name: Ganesh, S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Comet 49P/ Arend-Rigaux, thought to be a low activity comet since the 1980's was found to be active in its recent apparitions. Recent analysis of the data obtained from Spitzer observation of the comet in 2006 compared with laboratory spectra has revealed amorphous water ice on the surface. In addition, in 2012 a jet was found to appear during its subsequent perihelion passage as witnessed during an observation carried out on 26th March 2012 using the PRL telescope at Mt. Abu. This confirms recent activity of Comet 49P/Arend-Rigaux due to the volatile subsurface materials exposed after several passages close to the Sun. Our result confirms the subsurface ices on cometary nuclei and insists for more observations for a better understanding.
Untersuchungen zum Einfluss von Druckschwankungen des Kammergases auf den Betrieb der zentralen Spurenkammer des H1-Detektors
Creators: name: Linsel, Frank
name: DESY
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 1991
Subjects: Unveröffentlichte Hochschulschrift

description: Univ. Hamburg, Diplomarbeit, 1991; DESY Thesis (1991). = Univ. Hamburg, Diplomarbeit, 1991
Oligodendrocytes and Progenitors Become Progressively Depleted within Chronically Demyelinated Lesions
Creators: name: Matsushima, Glenn K.
name: Suzuki, Kinuko
name: Mason, Jeffrey L.
name: Toews, Arrel
name: Goldman, James E.
name: Morell, Pierre
name: Hostettler, Janell D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: To understand mechanisms that may underlie the progression of a demyelinated lesion to a chronic state, we have used the cuprizone model of chronic demyelination. In this study, we investigated the fate of oligodendrocytes during the progression of a demyelinating lesion to a chronic state and determined whether transplanted adult oligodendrocyte progenitors could remyelinate the chronically demyelinated axons. Although there is rapid regeneration of the oligodendrocyte population following an acute lesion, most of these newly regenerated cells undergo apoptosis if mice remain on a cuprizone diet. Furthermore, the oligodendrocyte progenitors also become progressively depleted within the lesion, which appears to contribute to the chronic demyelination. Interestingly, even if the mice are returned to a normal diet following 12 weeks of exposure to cuprizone, remyelination and oligodendrocyte regeneration does not occur. However, if adult O4+ progenitors are transplanted into the chronically demyelinated lesion of mice treated with cuprizone for 12 weeks, mature oligodendrocyte regeneration and remyelination occurs after the mice are returned to a normal diet. Thus, the formation of chronically demyelinated lesions induced by cuprizone appears to be the result of oligodendrocyte depletion within the lesion and not due to the inability of the chronically demyelinated axons to be remyelinated.
The Vascular Endothelial Growth Factor (VEGF) Receptor Flt-1 (VEGFR-1) Modulates Flk-1 (VEGFR-2) Signaling During Blood Vessel Formation
Creators: name: Johnson, Jennifer H.
name: Kearney, Joseph B.
name: Roberts, David M.
name: Bautch, Victoria L.
name: Kumar, Rakesh
name: Rosenberg, Michael P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Mice lacking the vascular endothelial growth factor (VEGF) receptor flt-1 (VEGFR-1) die from vascular overgrowth, caused primarily by aberrant endothelial cell division (Kearney JB, Ambler CA, Monaco KA, Johnson N, Rapoport RG, Bautch VL: Vascular endothelial growth factor receptor Flt-1 negatively regulates developmental blood vessel formation by modulating endothelial cell division. Blood 2002, 99:2397–2407). Because a second high-affinity VEGF receptor, flk-1, produces a positive endothelial proliferation signal, it was logical to ask whether flt-1 affects developmental blood vessel formation by modulating signaling through flk-1. Differentiated embryonic stem cell cultures lacking flt-1 (flt-1−/−) had increased flk-1 tyrosine phosphorylation, indicating that flk-1 signaling is up-regulated in the mutant background. The selective flk-1 inhibitor SU5416 partially rescued the flt-1−/− mutant phenotype, and this rescue was accompanied by a decrease in the relative amount of flk-1 tyrosine phosphorylation. Thus reduced flk-1 signal transduction can partially compensate for the lack of flt-1. The flt-1−/− mutant phenotype was also partially rescued by Flt-1/Fc, a truncated flt-1 that binds and sequesters the VEGF ligand. Taken together, these data show that down-regulation of flk-1 signaling by two different strategies partially rescues the developmental vascular overgrowth seen in the absence of flt-1, and they support a model whereby flt-1 modulates the flk-1 signal at an early point in the pathway.
Slovakia: Bibliographical database of Slovakian journalism and media research related to risks and opportunities for deliberative communication (2000–2020)
Creators: name: Gálik, Slavomír
name: Gáliková Tolnaiová, Sabína
name: Vrabec, Norbert
name: Čábyová, Ľudmila
name: Pravdová, Hana
name: Hudíková, Zora
name: Švecová, Magdaléna
name: Brník, Andrej
name: Krajčovič, Peter
name: Mináriková, Juliana
name: Radošinská, Jana
name: Višňovský, Ján
Publisher: name: Institute of Social Studies, University of Tartu
Year: 2023
Subjects: MEDIADELCOM
Bibliography
Journalism
News media research

description: The dataset is produced within the framework of the HORIZON 2020 project called MEDIADELCOM (Critical Exploration of Media Related Risks and Opportunities for Deliberative Communication: Development Scenarios of the European Media Landscape) in 2021-2022. The dataset is one of the 14 single-country data sets included in the consolidated file of country data sets (with 5623 entries), all in msw.xlsx format. All tables are searchable by 20 variables: full reference, year of publication, national/international publication, language, country the publication deals with, time of empirical data gathering, type of publication, open access/not OA, where referenced, focus on journalism domain, focus on media-related competences domain, focus on media usage patterns domain, focus on legal and ethical regulations domain, type of the approach, original key words, main topic, comments, country. As the data has been gathered specifically about the research done in four mentioned domains concerning potential ROs emanating from the news media development for deliberative communication, this database does NOT cover ALL the academic publications in the fields of media and journalism research. Consequently, the above-mentioned conditions limit the generalizations and comparisons based on the current database.
Aggravation of Anti-Myeloperoxidase Antibody-Induced Glomerulonephritis by Bacterial Lipopolysaccharide : Role of Tumor Necrosis Factor-α
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Wegener’s granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome, and idiopathic pauci-immune necrotizing crescentic glomerulonephritis are associated with myeloperoxidase (MPO)-specific anti-neutrophil cytoplasmic autoantibodies (ANCAs). Clinical and experimental evidence indicates that ANCA and proinflammatory stimuli of infectious origin act synergistically to cause vasculitis. We tested this hypothesis in a recently developed mouse model of anti-MPO IgG-induced glomerulonephritis by using bacterial lipopolysaccharide (LPS) as the proinflammatory stimulus. Systemic administration of LPS dose dependently increased renal injury induced by anti-MPO IgG as demonstrated by increased glomerular crescent formation and glomerular necrosis. In the early phase, LPS enhanced anti-MPO IgG-induced glomerular neutrophil accumulation. Furthermore, a transient induction of circulating tumor necrosis factor (TNF)-α levels, followed by a marked increase in circulating MPO levels, was observed on administration of LPS. In vitro, anti-MPO IgG induced a respiratory burst in murine neutrophils only after priming with TNF-α. Finally, anti-TNF-α treatment attenuated, but did not prevent, the LPS-mediated aggravation of anti-MPO IgG-induced glomerulonephritis. In conclusion, our study demonstrates that ANCA and proinflammatory stimuli act synergistically to induce vasculitic disease and suggests potential benefits of inhibiting TNF-α bioactivity in treating human ANCA-associated necrotizing crescentic glomerulonephritis.
Letter from Edmund Blunden to John Betjemen, September 20, 1964
Creators: name: Blunden, Edmund, 1896-1974
Publisher: name: University of Victoria Libraries
Year: 2023
Subjects: subject: Blunden, Edmund, 1896-1974
valueUri: http://id.worldcat.org/fast/55881
subject: Authors
valueUri: http://id.worldcat.org/fast/821688
subject: Literature, Modern
valueUri: http://id.worldcat.org/fast/1000172
subject: Poets, English
valueUri: http://id.worldcat.org/fast/1067870
subject: Betjeman, John, 1906-1984
valueUri: http://id.worldcat.org/fast/1427507
subject: Modernism (Literature)
valueUri: http://id.worldcat.org/fast/1024455
subject: Poets
valueUri: http://id.worldcat.org/fast/1067778
subject: Critics
valueUri: http://id.worldcat.org/fast/883769
subject: Authors, English
valueUri: http://id.worldcat.org/fast/821945
subject: Authors, English--Correspondence
valueUri: http://id.worldcat.org/fast/821953
subject: Television journalists
valueUri: http://id.worldcat.org/fast/1146949

description: Correspondence between John Betjemen and Edmund Blunden (English poet, writer, and critic). Blunden recently went to the dentist, and his dentist asked for Betjeman's autograph as payment for the treatment. Blunden asks Betjeman for this favour and gives him Miles Hely's address if he decides to do so. Blunden and his family have also bought a house and talks about moving. Has address of "Hall Mill Long Melford Suffolk" at the top.
Analysis of Orthologous Gene Expression between Human Pulmonary Adenocarcinoma and a Carcinogen-Induced Murine Model
Creators: name: Geraci, Mark W.
name: Chan, Zeng
name: Hirsch, Fred R.
name: Dwyer-Nield, Lori
name: Blaine, Stacy A.
name: Franklin, Wilbur A.
name: Zerbe, Laura
name: Baron, Anna E.
name: Johnson, Gary L.
name: Keith, Robert L.
name: Malkinson, Alvin M.
name: Stearman, Robert S.
name: Bunn, Paul A.
name: Merrick, Daniel T.
name: Nemenoff, Raphael A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Human adenocarcinoma (AC) is the most frequently diagnosed human lung cancer, and its absolute incidence is increasing dramatically. Compared to human lung AC, the A/J mouse-urethane model exhibits similar histological appearance and molecular changes. We examined the gene expression profiles of human and murine lung tissues (normal or AC) and compared the two species’ datasets after aligning ∼7500 orthologous genes. A list of 409 gene classifiers (P value <0.0001), common to both species (joint classifiers), showed significant, positive correlation in expression levels between the two species. A number of previously reported expression changes were recapitulated in both species, such as changes in glycolytic enzymes and cell-cycle proteins. Unexpectedly, joint classifiers in angiogenesis were uniformly down-regulated in tumor tissues. The eicosanoid pathway enzymes prostacyclin synthase (PGIS) and inducible prostaglandin E2 synthase (PGES) were joint classifiers that showed opposite effects in lung AC (PGIS down-regulated; PGES up-regulated). Finally, tissue microarrays identified the same protein expression pattern for PGIS and PGES in 108 different non-small cell lung cancer biopsies, and the detection of PGIS had statistically significant prognostic value in patient survival. Thus, the A/J mouse-urethane model reflects significant molecular details of human lung AC, and comparison of changes in orthologous gene expression may provide novel insights into lung carcinogenesis.
A Study on Consumer Perception, Intention and Satisfaction Towards FMCG In Coimbatore City of Tamilnadu
Creators: name: Dr.T.Nathiya, Shobika.M
Publisher: name: Zenodo
Year: 2025

description: In the Indian economy, the Fast-Moving Consumer Goods (FMCG) industry is crucial since it greatlyinfluences consumer purchasing trends. This study investigates how Coimbatore, Tamil Nadu, consumersperceive, intend to buy, and are satisfied with FMCG products. The goal of the study is to comprehendhow consumer decisions are influenced by several elements, such as pricing, brand image, promotionaltactics, and product quality. Structured questionnaires were used to gather information from a broadsample of customers in a number of different demographic groups. Price sensitivity and special offershave a substantial impact on purchase intention, but product quality and brand trust are important factorsinfluencing consumer opinion, according to the report.
ETNIK GURUHLAR PSIXOLOGIYASI
Creators: name: Rashidova, Zamira
Publisher: name: Zenodo
Year: 2023

description: Hozirgi vaqtda etnopsixologiya turli etnik guruhlar vakillari oʻrtasidagi psixologik farqlarni va ularning jamiyat darajasidagi madaniy, ijtimoiy, iqtisodiy va ekologik oʻzgaruvchilar bilan aloqalarini oʻrganadi. Zamonaviy sharoitda etnopsixologiyada etnik nizolarning psixologik sabablarini o'rganish, ularni hal etishning samarali yo'llarini izlash, shuningdek, milliy nizolarning o'sish manbalarini aniqlashga alohida e'tibor qaratilmoqda. o'z-o'zini anglash, uning turli ijtimoiy va milliy muhitda rivojlanishi muhim ahamiyatga egadir.
The Role of Neutrophils in the Induction of Glomerulonephritis by Anti-Myeloperoxidase Antibodies
Creators: name: Xiao, Hong
name: Hu, Peiqi
name: Jennette, J. Charles
name: Falk, Ronald J.
name: Heeringa, Peter
name: Liu, Zhi
name: Maeda, Nobuyo
name: Huugen, Dennis
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: In humans, circulating anti-neutrophil cytoplasm autoantibodies (ANCAs) with specificity for myeloperoxidase (MPO) are strongly associated with the development of pauci-immune necrotizing and crescentic glomerulonephritis (NCGN). In mice, we have demonstrated that intravenous injection of mouse antibodies specific for mouse MPO induces NCGN that closely mimics the human disease. We now report that the development of NCGN in this experimental model is accompanied by glomerular accumulation of neutrophils and macrophages. Neutrophil infiltration was most conspicuous at sites of glomerular necrosis and crescent formation, with macrophages also most numerous in crescents. Lymphocytes, however, were sparse in acute lesions. Importantly, mice that were depleted of circulating neutrophils with NIMP-R14 rat monoclonal antibodies were completely protected from anti-MPO IgG-induced NCGN. These findings provide direct evidence that neutrophils play a major role in the pathogenesis of anti-MPO-induced NCGN in this animal model and implicate neutrophils in the induction of human ANCA disease. This raises the possibility that therapeutic strategies to reduce circulating neutrophils could be beneficial to patients with ANCA-induced NCGN.
Analysis of the Transcriptome of Group A Streptococcus in Mouse Soft Tissue Infection
Creators: name: Porcella, Stephen F.
name: Parkins, Larye D.
name: Barry, William T.
name: Long, R. Daniel
name: Graham, Morag R.
name: Virtaneva, Kimmo
name: Welty, Diane M.
name: Wright, Fred A.
name: Gardner, Donald J.
name: Musser, James M.
name: Johnson, Claire A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Molecular mechanisms mediating group A Streptococcus (GAS)-host interactions remain poorly understood but are crucial for diagnostic, therapeutic, and vaccine development. An optimized high-density microarray was used to analyze the transcriptome of GAS during experimental mouse soft tissue infection. The transcriptome of a wild-type serotype M1 GAS strain and an isogenic transcriptional regulator knockout mutant (covR) also were compared. Array datasets were verified by quantitative real-time reverse transcriptase-polymerase chain reaction and in situ immunohistochemistry. The results unambiguously demonstrate that coordinated expression of proven and putative GAS virulence factors is directed toward overwhelming innate host defenses leading to severe cellular damage. We also identified adaptive metabolic responses triggered by nutrient signals and hypoxic/acidic conditions in the host, likely facilitating pathogen persistence and proliferation in soft tissues. Key discoveries included that oxidative stress genes, virulence genes, genes related to amino acid and maltodextrin utilization, and several two-component transcriptional regulators were highly expressed in vivo. This study is the first global analysis of the GAS transcriptome during invasive infection. Coupled with parallel analysis of the covR mutant strain, novel insights have been made into the regulation of GAS virulence in vivo, resulting in new avenues for targeted therapeutic and vaccine research.
SCALABLE - D3.5 Adaptation of pre-processing
Creators: name: Kuate, Raphael
Publisher: name: Zenodo
Year: 2022

description: The main objective of SCALABLE for CS GROUP is the improvement of LaBS deployment in bigger clusters of thousands of cores, achieved by a transfer of performance technology from WaLBerla. In the earlier work package 3.1, we have investigated the choice of an appropriate data structure organization for LaBS. We have shown that neither structured nor mixed structured/unstructured data organization were significantly more efficient compared to the current LaBS unstructured data design on industrial applications involving complex simulations. Therefore, this work package 3.5 focusses on adapting the pre-process step of LaBS for a solver step targeting GPU processors.
Letter from Edmund Blunden to John Betjemen, August 07, 1947
Creators: name: Blunden, Edmund, 1896-1974
Publisher: name: University of Victoria Libraries
Year: 2023
Subjects: subject: Authors, English--Correspondence
valueUri: http://id.worldcat.org/fast/821953
subject: Critics
valueUri: http://id.worldcat.org/fast/883769
subject: Literature, Modern
valueUri: http://id.worldcat.org/fast/1000172
subject: Television journalists
valueUri: http://id.worldcat.org/fast/1146949
subject: Betjeman, John, 1906-1984
valueUri: http://id.worldcat.org/fast/1427507
subject: Modernism (Literature)
valueUri: http://id.worldcat.org/fast/1024455
subject: Authors, English
valueUri: http://id.worldcat.org/fast/821945
subject: Poets
valueUri: http://id.worldcat.org/fast/1067778
subject: Poets, English
valueUri: http://id.worldcat.org/fast/1067870
subject: Authors
valueUri: http://id.worldcat.org/fast/821688
subject: Blunden, Edmund, 1896-1974
valueUri: http://id.worldcat.org/fast/55881

description: Correspondence between John Betjemen and Edmund Blunden (English poet, writer, and critic). Blunden sends Betjeman something (a document?) that might help him with his future research.
Sweden: Bibliographical database of Swedish journalism and media research related to risks and opportunities for deliberative communication (2000–2020)
Creators: name: Ots, Mart
name: Rapado, Irene
name: Berglez, Peter
name: Nord, Lars
Publisher: name: Institute of Social Studies, University of Tartu
Year: 2023
Subjects: MEDIADELCOM
Bibliography
Journalism
News media research

description: The dataset is produced within the framework of the HORIZON 2020 project called MEDIADELCOM (Critical Exploration of Media Related Risks and Opportunities for Deliberative Communication: Development Scenarios of the European Media Landscape) in 2021-2022. The dataset is one of the 14 single-country data sets included in the consolidated file of country data sets (with 5623 entries), all in msw.xlsx format. All tables are searchable by 20 variables: full reference, year of publication, national/international publication, language, country the publication deals with, time of empirical data gathering, type of publication, open access/not OA, where referenced, focus on journalism domain, focus on media-related competences domain, focus on media usage patterns domain, focus on legal and ethical regulations domain, type of the approach, original key words, main topic, comments, country. As the data has been gathered specifically about the research done in four mentioned domains concerning potential ROs emanating from the news media development for deliberative communication, this database does NOT cover ALL the academic publications in the fields of media and journalism research. Consequently, the above-mentioned conditions limit the generalizations and comparisons based on the current database.
The influence of patients’ sex on paramedic administration of analgesia: a rapid review
Creators: name: Dahoud, Sooaad
name: Naidoo, Navindhra
name: Simpson, Paul
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Public Health
subject: Emergency Medicine
subject: Pharmacy and Pharmaceutical Sciences
subject: Other Medical Specialties
subject: Medicine and Health Sciences
subject: Medical Specialties
subject: Other Medicine and Health Sciences
subject: Primary Care
subject: Acute Pain
subject: Ambulance
subject: Analgesia
subject: Emergency medical services
subject: gender disparity
subject: pain
subject: pain management
subject: paramedic
subject: paramedicine
subject: prehospital

description: This rapid review will be analysing whether a sex-specific discrepancy exists in the administration of analgesia for pain, in patients presenting prehospitally to an ambulance service.
Bibliographical data of media and journalism research related to risks and opportunities for deliberative communication in 14 countries (in 2000-2020): Austria, Bulgaria, Croatia, Czechia, Estonia, Germany, Greece, Hungary, Italy, Latvia, Poland, Romania, Slovakia, and Sweden
Creators: name: MEDIADELCOM
Publisher: name: Institute of Social Studies, University of Tartu
Year: 2023
Subjects: MEDIADELCOM
Bibliography
Journalism
News media research

description: The dataset is produced within the framework of the HORIZON 2020 project called MEDIADELCOM (Critical Exploration of Media Related Risks and Opportunities for Deliberative Communication: Development Scenarios of the European Media Landscape) in 2021-2022.
description: The dataset includes a consolidated file of 14 country data sets (with 5624 entries) and 14 single country data sets, all in msw.xlsx format. All tables are searchable by 20 variables: full reference, year of publication, national/international publication, language, country the publication deals with, time of empirical data gathering, type of publication, open access/not OA, where referenced, focus on journalism domain, focus on media related competences domain, focus on media usage patterns domain, focus on legal and ethical regulations domain, type of the approach, original key words, main topic, comments, country.
Simple model of Feshbach resonance in the strong-coupling regime
Creators: name: Wasak, T.
name: Krych, M.
name: Idziaszek, Z.
name: Trippenbach, M.
name: Avishai, Y.
name: Band, Y. B.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We use the dressed potentials obtained in the adiabatic representation of two coupled channels to calculate s-wave Feshbach resonances in a 3D spherically symmetric potential with an open channel interacting with a closed channel. Analytic expressions for the s-wave scattering length $a$ and number of resonances are obtained for a piecewise constant model with a piecewise constant interaction of the open and closed channels near the origin. We show analytically and numerically that, for strong enough coupling strength, Feshbach resonances can exist even when the closed channel does {\em not} have a bound state.
description: 9 pages, 8 figures
Inducible Nitric Oxide Synthase Mediates Prostaglandin H2 Synthase Nitration and Suppresses Eicosanoid Production
Creators: name: Gamss, Caryn
name: Shen, Hao
name: Kraemer, Rosemary
name: Maeda, Nobuyo
name: Deeb, Ruba S.
name: Gross, Steven S.
name: Hajjar, David P.
name: Lainé, Muriel
name: Summers, Barbara D.
name: Gavrilova, Tatyana
name: Hao, Gang
name: Upmacis, Rita K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Nitric oxide (NO) modulates the biological levels of arachidonate-derived cell signaling molecules by either enhancing or suppressing the activity of prostaglandin H2 isoforms (PGHS-1 and PGHS-2). Whether NO activates or suppresses PGHS activity is determined by alternative protein modifications mediated by NO and NO-derived species. Here, we show that inducible NO synthase (iNOS) and PGHS-1 co-localize in atherosclerotic lesions of ApoE−/− mouse aortae. Immunoblotting and immunohistochemistry revealed Tyr nitration in PGHS-1 in aortic lesions but markedly less in adjacent nonlesion tissue. PGHS-2 was also found in lesions, but 3-nitrotyrosine incorporation was not detected. 3-Nitrotyrosine formation in proteins is considered a hallmark reaction of peroxynitrite, which can form via NO-superoxide reactions in an inflammatory setting. That iNOS-derived NO is essential for 3-nitrotyrosine modification of PGHS-1 was confirmed by the absence of 3-nitrotyrosine in lesions from ApoE−/−iNOS−/− mice. Mass spectrometric studies specifically identified the active site residue Tyr385 as a 3-nitrotyrosine modification site in purified PGHS-1 exposed to peroxynitrite. PGHS-mediated eicosanoid (PGE2) synthesis was more than fivefold accelerated in cultured iNOS−/− versus iNOS-expressing mouse aortic smooth muscle cells, suggesting that iNOS-derived NO markedly suppresses PGHS activity in vascular cells. These results further suggest a regulatory role of iNOS in eicosanoid biosynthesis in human atherosclerotic lesions.
ФИБРОБЛАСТЛАР ЎСИШ ОМИЛИ-23 ВА КЛОТО ОҚСИЛИ ЎҚИНИНГ ДИАБЕТИК НЕФРОПАТИЯСИДА ЎЗГАРИШИ
Creators: name: Назарова, Нозимахон
name: Алиханова, Нодира
Publisher: name: Zenodo
Year: 2023

description: Сўнги йилларда тадқиқотчилар диққати СБКнинг янги биомаркерлари: СБКда фосфат, кальций ва Д витамини алмашинувида иштирок этувчи Фибробластлар ўсиш омили-23 (FGF23)  ва Клото оқсилига қаратилган [1]. Мавжуд маълумотлар шуни кўрсатадики, фосфор гомеостазининг марказий модулятори бўлган Клото оқсили ва FGF23 эндокрин фаолликга эга бўлиб, сурункали буйрак кассалиги билан касалланган беморларда томирлар кальцификациясида ва ЮКТК ривожланишида иштирок этади [2].
Language Instructors’ Digital Competences in the Context of Emergency Remote Teaching: A Professional Didactics Perspective
Creators: name: Landry, Jill
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2022
Subjects: ERT
French
language
Instructor
online
digital
didactics
pandemic
Covid-19

description: This thesis presents ten interviews with French language teachers regarding their experience of emergency remote teaching (ERT) during the Covid-19 pandemic. Their responses are analysed through the lens of professional didactics (Pastré, 1999), and by looking at models that have been created to describe the adoption of technology. The interviews are placed in the context of similar studies done before or during the pandemic. The instructors in this study were asked to describe their experiences from the sudden switch to online teaching during the pandemic and for the first eighteen months of it, including how they coped, what new digital competencies they developed and how, their perception as online teachers. and the digital practices they would like to carry forward. The models to describe technology integration are revisited in the context of ERT. Recommendations are made for stakeholders for language instructors’ professional development in the case of future ERT scenarios.
Alternative Complement Pathway in the Pathogenesis of Disease Mediated by Anti-Neutrophil Cytoplasmic Autoantibodies
Creators: name: Falk, Ronald J.
name: Schreiber, Adrian
name: Xiao, Hong
name: Jennette, J. Charles
name: Heeringa, Peter
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Clinical and experimental data indicate that anti-neutrophil cytoplasmic autoantibodies (ANCAs) cause glomerulonephritis and vasculitis. Here we report the first evidence that complement is an important mediator of ANCA disease. Transfer of anti-myeloperoxidase (MPO) IgG into wild-type mice or anti-MPO splenocytes into immune-deficient mice caused crescentic glomerulonephritis that could be completely blocked by complement depletion. The role of specific complement activation pathways was investigated using mice with knockout of the common pathway component C5, classic and lectin binding pathway component C4, and alternative pathway component factor B. After injection of anti-MPO IgG, C4−/− mice developed disease comparable with wild-type disease; however, C5−/− and factor B−/− mice developed no disease. To substantiate a role for complement in human ANCA disease, IgG was isolated from patients with myeloperoxidase ANCA (MPO-ANCA) or proteinase 3 ANCA (PR3-ANCA) and from controls. Incubation of MPO-ANCA or PR3-ANCA IgG with human neutrophils caused release of factors that activated complement. IgG from healthy controls did not produce this effect. The findings suggest that stimulation of neutrophils by ANCA causes release of factors that activate complement via the alternative pathway, thus initiating an inflammatory amplification loop that mediates the severe necrotizing inflammation of ANCA disease.
title: Bataille et Hegel dans “Théorie de la religion”
Creators: name: Ernst , Gilles
Publisher: name: Roma Tre-Press
Year: 2010

description: Théorie de la religion fait partie de ce vaste cimitière de Bataille où gisent les divers projets de " somme " et les livres inachevés. Rédigé au début del 1948, cet essai devait paraître en décembre de la même année ; mais, faute d'avoiur été complété par Bataille, il n'a jamais été publié de son vivant. Le titre est à la fois exact et restrictif. Il est exact quand Bataille parle de la religion stricto sensu (adoptand le point de vue marxiste, il la considère comme la phase des mythes qui précède l'avènement de la science). Mais il est restrictif car l'essai porte plutôt sur l'omniprésence du sacré, tel que l'entend Bataille, dans le comportements humains. Théorie de la religion appartient donc au versant économico-anthropologique de la pensée de Bataille, où il complète La Part maudite et La Limite de l'utile.

description: B@belonline vol. 9 Scienza e sapienza nel Medioevo. Agostinismo e aristotelismo a confronto
Activity-induced phase separation and self-assembly in mixtures of active and passive particles
Creators: name: Stenhammar, Joakim
name: Wittkowski, Raphael
name: Marenduzzo, Davide
name: Cates, Michael E.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Biological Physics (physics.bio-ph)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: We investigate the phase behavior and kinetics of a monodisperse mixture of active (\textit{i.e.}, self-propelled) and passive isometric Brownian particles through Brownian dynamics simulations and theory. As in a purely active system, motility of the active component triggers phase separation into a dense and a dilute phase; in the dense phase we further find active-passive segregation, with "rafts" of passive particles in a "sea" of active particles. We find that phase separation from an initially disordered mixture can occur with as little as 15 percent of the particles being active. Finally, we show that a system prepared in a suitable fully segregated initial state reproducibly self-assembles an active "corona" which triggers crystallization of the passive core by initiating a compression wave. Our findings are relevant to the experimental pursuit of directed self-assembly using active particles.
IN VITRO AND IN VIVO MODELLING OF CORNELIA DE LANGE SYNDROME CAUSATIVE MUTATIONS: WNT ACTIVATION AS A POSSIBLE THERAPEUTIC APPROACH
Creators: name: GRAZIOLI, PAOLO
Publisher: name: Universit� degli Studi di Milano
Year: 2021

description: La sindrome di Cornelia de Lange (CdLS) � una rara malattia genetica che colpisce ogni distretto del corpo, compreso il sistema nervoso centrale, causando un ritardo variabile del neurosviluppo. Le malformazioni causate da questa sindrome derivano da mutazioni a carico di geni del complesso delle coesine (complesso proteico coinvolto nel controllo della coesione dei cromatidi fratelli) e da un?alterata regolazione di pathway molecolari durante lo sviluppo, tra cui il pathway canonico di WNT, che risulta essere meno attivo. Al fine di osservare un miglioramento del fenotipo, ho indagato i potenziali effetti positivi dell?utilizzo di cloruro di litio come attivatore del pathway canonico di WNT, avvalendomi di due modelli differenti: cellule staminali pluripotenti indotte di origine umana (hiPSCs) e Drosophila melanogaster. Per simulare un?aploinsufficienza delle coesine, le hiPSCs differenziate in precursori neurali (hNPC), sono state trattate con uno specifico inibitore della proteina HDAC8, nota per essere implicata nella patogenesi della CdLS. Dopo essere state trattate con cloruro di litio, queste cellule hanno mostrato una migliorata capacit� di differenziamento attraverso il lineage neuronale. Esemplari adulti di Drosophila melanogaster portatori di un allele loss-of-function a carico di un gene delle coesine, dopo essere stati allevati su cibo supplementato con litio come attivatore del pathway canonico di WNT, hanno mostrato un recupero statisticamente significativo della morfologia dei mushroom bodies, una struttura del sistema nervoso centrale importante per l'apprendimento olfattivo e la memoria. I risultati derivanti da questo progetto di dottorato supportano ulteriormente l?ipotesi che una perturbazione del pathway canonico di WNT, causato da mutazioni a carico delle coesine, giochi un ruolo centrale nell?eziopatogenesi della CdLS. Questa teoria � corroborata dal recupero consistente del fenotipo nei modelli sperimentali grazie alla somministrazione di cloruro di litio e apre la strada a possibili strategie terapeutiche, fortemente necessarie per la CdLS.
The clustering of baryonic matter. II: halo model and hydrodynamic simulations
Creators: name: Fedeli, C.
name: Semboloni, E.
name: Velliscig, M.
name: Van Daalen, M.
name: Schaye, J.
name: Hoekstra, H.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We recently developed a generalization of the halo model in order to describe the spatial clustering properties of each mass component in the Universe, including hot gas and stars. In this work we discuss the complementarity of the model with respect to a set of cosmological simulations including hydrodynamics of different kinds. We find that the mass fractions and density profiles measured in the simulations do not always succeed in reproducing the simulated matter power spectra, the reason being that the latter encode information from a much larger range in masses than that accessible to individually resolved structures. In other words, this halo model allows one to extract information on the growth of structures from the spatial clustering of matter, that is complementary with the information coming from the study of individual objects. We also find a number of directions for improvement of the present implementation of the model, depending on the specific application one has in mind. The most relevant one is the necessity for a scale dependence of the bias of the diffuse gas component, which will be interesting to test with future detections of the Warm-Hot Intergalactic Medium. This investigation confirms the possibility to gain information on the physics of galaxy and cluster formation by studying the clustering of mass, and our next work will consist of applying the halo model to use future high-precision cosmic shear surveys to this end.
description: 20 pages, 9 figures. Accepted for publication on JCAP
Myeloperoxidase Interacts with Endothelial Cell-Surface Cytokeratin 1 and Modulates Bradykinin Production by the Plasma Kallikrein-Kinin System
Creators: name: Falk‡, Ronald J.
name: Mahdi, Fakhri
name: Preston‡, Gloria A.
name: Jennette‡, J. Charles
name: Pendergraft, William F.
name: Schmaier, Alvin H.
name: Astern‡, Joshua M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: During an inflammatory state, functional myeloperoxidase (MPO) is released into the vessel as a result of intravascular neutrophil degradation. One mechanism of resulting cellular injury involves endothelial internalization of MPO, which causes oxidative damage and impairs endothelial signaling. We report the discovery of a protein that facilitates MPO internalization, cytokeratin 1 (CK1), identified using affinity chromatography and mass spectrometry. CK1 interacts with MPO in vitro, even in the presence of 100% human plasma, thus substantiating biological relevance. Immunofluorescent microscopy confirmed that MPO added to endothelial cells can co-localize with endogenously expressed CK1. CK1 acts as a scaffolding protein for the assembly of the vasoregulatory plasma kallikrein-kinin system; thus we explored whether MPO and high molecular weight kininogen (HK) reside on CK1 together or whether they compete for binding. The data support cooperative binding of MPO and HK on cells such that MPO masked the plasma kallikrein cleavage site on HK, and MPO-generated oxidants caused inactivation of both HK and kallikrein. Collectively, interactions between MPO and the components of the plasma kallikrein-kinin system resulted in decreased bradykinin production. This study identifies CK1 as a facilitator of MPO-mediated vascular responses and thus provides a new paradigm by which MPO affects vasoregulatory systems.
H I Kinematics of the Large Magellanic Cloud revisited : Evidence of possible infall and outflow
Creators: name: Indu, G.
name: Subramaniam, Annapurni
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The neutral atomic Hydrogen (H I) kinematics of the Large Magellanic Cloud (LMC) is revisited in light of two new proper motion estimates. We analysed the intensity weighted H I velocity maps of the ATCA/Parkes and GASS data sets. We corrected the line of sight velocity field for the systemic, transverse, precession, and nutation motions of the disk using two recent proper motion estimates, and estimated the kinematic parameters of the H I disk. The value of position angle (PA) of kinematic major axis estimated using ATCA/Parkes data is found to be similar to the recent estimate of the PA using stellar tracers. The effect of precession and nutation in the estimation of PA is found to be significant. Using ATCA/Parkes data, most of the H I gas in the LMC is found to be located in the disk. We detected 12.1% of the data points as kinematic outliers. We identified the well-known Arm E, Arm S, Arm W, Arm B and a new stream, Outer Arm, as part of outlier components. The GASS data analysis brings out the velocity details of the Magellanic Bridge (MB) and its connection to the LMC disk. We find that the Arm B and the Outer Arm are connected to the MB. We detect high velocity gas in the western disk of the LMC and the south-west and southern parts of the MB. We proposed two models (in plane and out of plane) to explain the outlier gas. We suggest that the Arm B could be an infall feature, originating from the inner MB. The Arm E could be an outflow feature. We suggest possible outflows from the western LMC disk and south and south western MB, which could be due to ram pressure. The velocity pattern observed in the MB suggests that it is being sheared. We suggest that the various outliers identified in this study may be caused by a combination of tidal effects and hydrodynamical effect due to the motion of the LMC in the Milky Way (MW) halo.
description: Accepted in A&A for publication. 15 pages, 14 figures
The Cartilage Matrix Protein Subdomain of Type VII Collagen Is Pathogenic for Epidermolysis Bullosa Acquisita
Creators: name: Woodley, David T.
name: Hou, Yingping
name: Liu, Ziu
name: Chen, Mei
name: Wang, Xinyi
name: Remington, Jennifer
name: Doostan, Arvin
name: Bandyopadhyay, Pubali
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Epidermolysis bullosa acquisita (EBA) is an acquired bullous disease of the skin characterized by IgG autoantibodies against type VII (anchoring fibril) collagen. We previously defined four immunodominant antigenic epitopes within the noncollagenous 1 (NC1) domain of type VII collagen. In this study, we produced an additional recombinant fusion protein from the NC1 domain corresponding to the N-terminal 227 amino acids (residues 1 to 227), which contains homology with cartilage matrix protein (CMP). Using enzyme-linked immunosorbent assay and immunoblot analysis, we tested sera from EBA patients (n = 32), bullous systemic lupus erythematosus patients (n = 3), bullous pemphigoid patients (n = 15), and normal humans (n = 12). Twenty-six of 32 EBA sera and two of three bullous systemic lupus erythematosus sera reacted with the CMP domain, whereas none of the control sera did. Affinity-purified anti-CMP EBA antibodies injected into hairless mice produced the clinical, histological, immunological, and ultrastructural features of EBA. F(ab′)2 fragments generated from anti-CMP EBA autoantibodies did not induce disease. Our studies provide the first evidence that EBA autoantibodies to the CMP subdomain of NC1 are pathogenic and induce blister formation. This is the first antigenic epitope on type VII collagen demonstrated to be a pathogenic target for EBA autoantibodies.
Electronic Bloch oscillation in bilayer graphene gradient superlattices
Creators: name: Cheng, Hemeng
name: Li, Changan
name: Ma, Tianxing
name: Wang, Li-Gang
name: Song, Yun
name: Lin, Hai-Qing
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We investigate the electronic Bloch oscillation in bilayer graphene gradient superlattices using transfer matrix method. By introducing two kinds of gradient potentials of square barriers along electrons propagation direction, we find that Bloch oscillations up to terahertz can occur. Wannier-Stark ladders, as the counterpart of Bloch oscillation, are obtained as a series of equidistant transmission peaks, and the localization of the electronic wave function is also signature of Bloch oscillation. Forthermore, the period of Bloch oscillation decreases linearly with increasing gradient of barrier potentials.
description: 5 Pages, 7 Figures, and more discussions and references are added. Accepted for publication in Applied Physics Letters
Hot-electron cooling by acoustic and optical phonons in monolayers of MoS$_2$ and other transition-metal dichalcogenides
Creators: name: Kaasbjerg, Kristen
name: Bhargavi, K. S.
name: Kubakaddi, S. S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study hot-electron cooling by acoustic and optical phonons in monolayer MoS$_2$. The cooling power $P$ ($P_e = P/n$) is investigated as a function of electron temperature $T_e$ (0-500 $\mathrm{K}$) and carrier density $n$ ($10^{10}$-$10^{13}$ $\mathrm{cm}^{-2}$) taking into account all relevant electron-phonon (el-ph) couplings. We find that the cross over from acoustic phonon dominated cooling at low $T_e$ to optical phonon dominated cooling at higher $T_e$ takes place at $T_e \sim 50$-$75$ $\mathrm{K}$. The unscreened deformation potential (DP) coupling to the TA phonon is shown to dominate $P$ due to acoustic phonon scattering over the entire temperature and density range considered. The cooling power due to screened DP coupling to the LA phonon and screened piezoelectric (PE) coupling to the TA and LA phonons is orders of magnitude lower. In the Bloch-Grüneisen (BG) regime, $P\sim T_e^4$ ($T_e^6$) and $P\sim n^{-1/2}$ ($P_e\sim n^{-3/2}$) are predicted for unscreened (screened) el-ph interaction. The cooling power due to optical phonons is dominated by zero-order DP couplings and the Fröhlich interaction, and is found to be significantly reduced by the hot-phonon effect when the phonon relaxation time due to phonon-phonon scattering is large compared to the relaxation time due to el-ph scattering. The $T_e$ and $n$ dependence of the hot-phonon distribution function is also studied. Our results for monolayer MoS$_2$ are compared with those in conventional two-dimensional electron gases (2DEGs) as well as monolayer and bilayer graphene.
description: 14 pages, 10 figures, published version
MAKTABGACHA YOSHDAGI BOLALARDA TORTINCHOQLIK MUAMMOSI
Creators: name: Abdillayeva, Surayyo
Publisher: name: Zenodo
Year: 2023

description: Ushbu maqolada maktabgacha yoshdagi bolalarda ijtimoiy psixologik moslashuv shakllanishining o'ziga xos xususiyatlari va bu jarayonda bolada kechadigan noto'g'ri psixologik rivojlanishlarni psixologik metodikalar xulosalaridan olingan natijalarga ko'ra ya'ni tortinchoqlik, uyatchanlik, jizzakilik, o'jarlik kabilarni psixokorreksiya qilish haqida yoritib berilgan.
Entropy in the Kuramoto model and its implications for the stability of partially synchronized states
Creators: name: Nordenfelt, Anders
Publisher: name: arXiv
Year: 2014
Subjects: subject: Pattern Formation and Solitons (nlin.PS)
subject: FOS: Physical sciences

description: We discuss the concept of entropy applied to the infinite-N Kuramoto model and derive an expression for its time derivative. The time derivative of the entropy functional is shown to depend on the synchronization order parameter in a very simple way and, absent diffusion, it is never increasing. The implications of this for the stability of partially synchronized states is discussed. We conclude with a section on the entropy of the marginal density function averaged over all natural frequencies.