cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Synergistic anti-tumor effects of combined gemcitabine and cisplatin nanoparticles in a stroma-rich bladder carcinoma model
Creators: name: Kim, William Y.
name: Huang, Leaf
name: Miao, Lei
name: Guo, Shutao
name: Zhang, Yuan
name: Satterlee, Andrew
name: Zhang, Jing
name: Zhang, Lu
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Tumors grown in a stroma-rich mouse model resembling clinically advanced bladder carcinoma with UMUC3 and NIH 3T3 cells have high levels of fibroblasts and an accelerated tumor growth rate. We used this model to investigate the synergistic effect of combined gemcitabine monophosphate (GMP) nanoparticles and Cisplatin nanoparticles (Combo NP) on tumor-associated fibroblasts (TAFs). A single injection of Combo NP had synergistic anti-tumor effects while the same molar ratio of combined GMP and Cisplatin delivered as free drug (Combo Free) fell outside of the synergistic range. Combo NP nearly halted tumor growth with little evidence of general toxicity while Combo Free had only a modest inhibitory effect at 16 mg/kg GMP and 1.6 mg/kg Cisplatin. Combo NP increased levels of apoptosis within the tumor by approximately 1.3 fold (TUNEL analysis) and decreased α-SMA-positive fibroblast recruitment by more than 87% (immunofluorescence) after multiple injections compared with Combo Free, GMP NP or Cisplatin NP alone. The TAF-targeting capability of Combo NP was evaluated by double staining for TUNEL and α-SMA at various time points after a single injection. On day one after injection, 57% of the TUNEL-positive cells were identified as α-SMA-positive fibroblasts. By day four, tumor stroma was 85% depleted and 87% of the remaining TAFs were TUNEL-positive. Combo NP-treated tumors became 2.75 fold more permeable than those treated with Combo Free as measured by Evans Blue. We conclude that the antineoplastic effect of Combo NP works by first targeting TAFs and is more effective as an anti-tumor therapy than Combo Free, GMP NP or Cisplatin NP alone.
The Kiselev solution in power-Maxwell electrodynamics
Creators: name: Dariescu, Marina-Aura
name: Dariescu, Ciprian
name: Lungu, Vitalie
name: Stelea, Cristian
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this work we reconsider the solution describing black holes surrounded by a `quintessence'-like fluid. This geometry was introduced by Kiselev in 2003 and its physical source was originally modeled by an anisotropic fluid. We show that the Kiselev geometry is actually an exact solution of the Einstein equations coupled to nonlinear electrodynamics. More specifically, we show that the Kiselev geometry becomes an exact solution in the context of power-Maxwell electrodynamics, using either an electric ansatz or a magnetic one. In both cases the physical source can be modeled by a power-Maxwell Lagrangian, albeit with different powers corresponding to the electric or the magnetic charges. We briefly investigate the motion of charged particles in this geometry. Finally, we give the proper interpretation of the black-hole thermodynamics in this context. Similarly to the Schwarzschild-de Sitter case, we note the presence of the Schottky peaks in the heat capacity, signaling out the possibility of this thermodynamic black hole system to function as a continuous heat machine.
description: 29 pages, 4 figures; v. 3 removed one section, improved the overall presentation
The Detection of Earth-mass Planets around Active Stars: The Mass of Kepler-78b
Creators: name: Hatzes, Artie P.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Kepler-78b is a transiting Earth-mass planet in an 8.5 hr orbit discovered by the Kepler Space Mission. We performed an analysis of the published radial velocity measurements for Kepler-78 in order to derive a refined measurement for the planet mass. Kepler-78 is an active star and radial velocity variations due to activity were removed using a Floating Chunk Offset (FCO) method where an orbital solution was made to the data by allowing the velocity offsets of individual nights to vary. We show that if we had no a priori knowledge of the transit period the FCO method used as a periodogram would still have detected Kepler-78b in the radial velocity data. It can thus be effective at finding unknown short-period signals in the presence of significant activity noise. Using the FCO method while keeping the ephemeris and orbital phase fixed to the photometric values and using only data from nights where 6-10 measurements were taken results in a K-amplitude of 1.34 +/- 0.25 m/s. a planet mass of 1.31 +/- 0.24 M_Earth, and a planet density of rho = 4.5 (-2.0/+2.2) g/cm^3. Allowing the orbital phase to be a free parameter reproduces the transit phase to within the uncertainty. The corresponding density implies that Kepler-78b may have a structure that is deficient in iron and is thus more like the Moon. Although the various approaches that were used to filter out the activity of Kepler 78 produce consistent radial velocity amplitudes to within the errors, these are still too large to constrain the structure of this planet. The uncertainty in the mass for Kepler-78b is large enough to encompass models with structures ranging from Mercury-like (iron enriched) to Moon-like (iron deficient). A more accurate K-amplitude as well as a better determination of the planet radius are needed to distinguish between these models.
description: 10 pages, 15 figures, accepted by Astronomy and Astrophysics
Energy Extraction via Magnetic Reconnection in Lorentz breaking Kerr-Sen and Kiselev Black Holes
Creators: name: Carleo, Amodio
name: Lambiase, Gaetano
name: Mastrototaro, Leonardo
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Black holes can accumulate a large amount of energy, responsible for highly energetic astrophysical phenomena Recently, fast magnetic reconnection (MR) of the magnetic field was proposed as a new way to extract energy and in this paper, we investigate this phenomena in a bumblebee Kerr-Sen BH. We find that the presence of the charge parameter strongly changes the simple Kerr case, making this extraction mechanism possible even for not extremely rotating black holes ($a \sim 0.7$). We also show that, under appropriate circumstances, MR is more efficient compared to the Blandford-Znajek mechanism. We finally compare these results with quintessence black-hole solutions not finding and enhancement respect to Kerr solution.
Wird irgendetwas mit mir geschehen? Psycho(patho)logical perspectives on Hannah Arendt’s The Banality of Evil
Creators: name: De Pieri, Veronica
Publisher: name: DIVE-IN – An International Journal on Diversity and Inclusion
Year: 2023

description: In 1961, the Eichmann trial opened in Jerusalem, and its worldwide resonance through media coverage questioned the collective conscience about responsibility for Nazi crimes. German philosopher Hannah Arendt attended the process as a special correspondent for the U.S. magazine The New Yorker. Her Eichmann in Jerusalem: A Report on the Banality of Evil (1963) caused a great scandal: the author advanced the brazen idea of collective co-responsibility for Nazi crimes, reporting the identikit of a standard bureaucrat, a seemingly ordinary man, just like any one of us. Almost sixty years after its publication, this study adopts a primarily psycho(patho)logical perspective to reflect once again on the considerations Arendt shared in the Banality of Evil. In showing the multiple facets of banality, the research investigates recent results in the analysis of the criminal mind in order to shed light on the etiology of evil.
description: DIVE-IN – An International Journal on Diversity and Inclusion, Vol. 3 No. 1 (2023): Täter, Mitläufer, and the Responsibility for Evil
Plausibility of ultraviolet burst generation in the low solar chromosphere
Creators: name: Ni, Lei
name: Cheng, Guanchong
name: Lin, Jun
Publisher: name: arXiv
Year: 2022
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Plasma Physics (physics.plasm-ph)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: Ultraviolet (UV) bursts and Ellerman bombs (EBs) are small-scale magnetic reconnection events taking place in the highly stratified, low solar atmosphere. It is still not clear whether UV bursts have to be generated at a higher atmospheric layer than EBs or whether both UV bursts and EBs can occur in the low chromosphere. We numerically studied the low $β$ magnetic reconnection process around the solar temperature minimum region (TMR). The time-dependent ionization degrees of hydrogen and helium are included in the MHD code, which lead to a more realistic magnetic diffusion caused by electron-neutral collision and ambipolar diffusion. A more realistic radiative cooling model from Carlsson & Leenaarts 2012 is included in the simulations. Our results in high resolution indicate that the plasmas in the reconnection region are heated up to more than $20,000$ K if the reconnecting magnetic field is as strong as $500$ G, which suggests that UV bursts can be generated in the dense low chromosphere. The dominant mechanism for producing the UV burst in the low chromosphere is heating, as a result of the local compression in the reconnection process. The thermal energy occurring in the reconnection region rapidly increases after the turbulent reconnection mediated by plasmoids is invoked. The average power density of the generated thermal energy in the reconnection region can reach over $1000$ erg cm$^{-3}$ s$^{-1}$, which is comparable to the average power density accounting for a UV burst. With the strength of the reconnecting magnetic field exceeding $900$ G, the width of the synthesized Si IV 1394 A line profile with multiple peaks can reach up to $100$ km s$^{-1}$, which is consistent with observations.
description: 12 pages, 10 figures
Spatially Resolved Chemistry in Nearby Galaxies III. Dense Molecular Gas in the Inner Disk of the LIRG IRAS 04296+2923
Creators: name: Meier, David S.
name: Turner, Jean L.
name: Beck, Sara C.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present a survey of 3 mm molecular lines in IRAS 04296+2923, one of the brightest known molecular-line emitting galaxies, and one of the closest LIRGs. Data are from the Owens Valley and CARMA millimeter interferometers. Species detected at ~<4" resolution include C^18O, HCN, HCO+, HNC, CN, CH_3OH and, tentatively, HNCO. Along with existing CO, ^13CO and radio continuum data, these lines constrain the chemical properties of the inner disk. Dense molecular gas in the nucleus fuels a star formation rate ~>10 M_sun/yr and is traced by lines of HCN, HCO+, HNC, and CN. A correlation between HCN and star formation rate is observed on sub-kpc scales, consistent with global relations. Toward the nucleus, CN abundances are similar to those of HCN, indicating emission comes from a collection (~40-50) of moderate visual extinction, photon-dominated region clouds. The CO isotopic line ratios are unusual: CO(1-0)/^13CO(1-0) and CO(1-0)/C^18O(1-0) line ratios are large toward the starburst, as is commonly observed in LIRGs, but farther out in the disk these ratios are remarkably low (~<3). ^13CO/C^18O abundance ratios are lower than in Galactic clouds, possibly because the C^18O is enriched by massive star ejecta from the starburst. ^13CO is underabundant relative to CO. Extended emission from CH_3OH indicates that dynamical shocks pervade both the nucleus and the inner disk. The unusual CO isotopologue ratios, the CO/HCN intensity ratio versus L_IR, the HCN/CN abundance ratio and the gas consumption time versus inflow rate, all indicate that the starburst in IRAS 04296+2923 is in an early stage of development.
description: 15 pages, 5 figures; Accepted for publication in the Astrophysical Journal
A Simple Bootstrap Method for Panel Data Inferences
Creators: name: Gao, Jiti
name: Peng, Bin
name: Yan, Yayi
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: In this paper, we propose a simple dependent wild bootstrap procedure for us to establish valid inferences for a wide class of panel data models including those with interactive fixed effects. The proposed method allows for the error components having weak correlation over both dimensions, and heteroskedasticity. The asymptotic properties are established under a set of simple and general conditions, and bridge the literature on bootstrap methods and the literature of heteroskedasticity and autocorrlation consistent (HAC) approaches for panel data models. The new findings fill some gaps left by the bulk literature of the block bootstrap based panel data studies. Finally, we show the superiority of our approach over several natural competitors using extensive numerical studies.
On the saturation number for cubic surfaces
Creators: name: Wang, Yuchao
Publisher: name: arXiv
Year: 2014
Subjects: subject: Number Theory (math.NT)
subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 11D25, 11P32, 11P55, 11N36

description: We investigate the density of rational points on the Fermat cubic surface and the Cayley cubic surface whose coordinates have few prime factors. The key tools used are the weighted sieve, the circle method and universal torsors.
description: 20 pages, substantial overlaps with arXiv:1406.6963
Enhancing Reliability in 6G Networks Based on User-Driven AI
Creators: name: Betzelos, Christos
name: Uzunidis, Dimitris
name: Leligou, Helen
name: Karkazis, Panagiotis
Publisher: name: Zenodo
Year: 2024

description: In the sixth-generation (6G) era of mobile networks, services will be around users, following a user-centric approach. Inspired by the fifth-generation (5G) network paradigms, this redesigned architecture will be driven by the openness of the 6G system and the distributed edge-cloud continuum. Artificial Intelligence and Machine Learning (AI/ML) integration to the network brings the latest emerging advancements in the field. Mission-critical applications, such as remote surgery, metaverse, and autonomous vehicles, expect high Quality of Experience (QoE) which can only be ensured through strong network and service reliability. In this paper, we propose a novel framework for ensuring user-centric reliability on 6G networks, based on AI algorithms, that extends over the whole 6G edge-cloud  continuum infrastructure. In particular, we present two profiling methods (service and security) that are able to identify and act proactively against malicious activities and infrastructure-related issues using AI, taking into account the unique user characteristics. We also perform an evaluation analysis aiming to designate the need and the invaluable use of the user-centric characteristics, e.g., user position, speed, etc., when trying to optimize the QoE and ensure reliability.
Holographic Perspectives On Models Of Moduli Stabilization In M-Theory
Creators: name: Ning, Sirui
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Recent holographic analyses on IIA and IIB models of moduli stabilization have led to many interesting results. Here we extend this approach to M-Theory. We consider both flux-stabilized models and non-perturbative stabilization methods. We perform a holographic analysis to determine the spectrum of the assumed dual $CFT_{3}$ to see its AdS/CFT implication. For the flux stabilization, which relies on a large complex Chern-Simons invariant, moduli have integer dimensions similar to the DGKT flux-stabilized model in type IIA,. For the non-perturbative stabilization, the results are similar to racetrack models in type IIB.
Parameters of microdiffusion in f.c.c.-Ni-Mo solid solutions
Creators: name: Bokoch, S. M.
name: Kulish, M. P.
name: Tatarenko, V. A.
name: Radchenko, T. M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The time evolution of diffuse X-ray scattering intensities conditioned by the short-range order (SRO) in Ni-Mo solid solutions is investigated. As shown, the transition from a quenched (nonequilibrium) state to the equilibrium one is accompanied by the complex time reorganization of various SRO types. Computer simulations of local atomic configurations in alloy with use of the Monte Carlo method, inhomogeneous-SRO model, and calculation of electron density of states (DOS) at the Fermi level give the opportunity of obtaining quantitative characteristics of atomic reconfigurations. The relaxation times of diffuse X-ray scattering intensities and Fourier components of atom jumps for different wave vectors k in reciprocal space are determined. Based on the microdiffusion model for f.c.c. solid solution, the micro- and macroscopic parameters of the atom migration of both components in Ni-Mo solid solutions are investigated.
Dust ring and gap formation by gas flow induced by low-mass planets embedded in protoplanetary disks $\rm I$. Steady-state model
Creators: name: Kuwahara, Ayumu
name: Kurokawa, Hiroyuki
name: Tanigawa, Takayuki
name: Ida, Shigeru
Publisher: name: arXiv
Year: 2022
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Recent high-spatial-resolution observations have revealed dust substructures in protoplanetary disks such as rings and gaps, which do not always correlate with gas. Because radial gas flow induced by low-mass, non-gas-gap-opening planets could affect the radial drift of dust, it potentially forms these dust substructures in disks. We investigate the potential of gas flow induced by low-mass planets to sculpt the rings and gaps in the dust profiles. We first perform three-dimensional hydrodynamical simulations, which resolve the local gas flow past a planet. We then calculate the trajectories of dust influenced by the planet-induced gas flow. Finally, we compute the steady-state dust surface density by incorporating the influences of the planet-induced gas flow into a one-dimensional dust advection-diffusion model. The outflow of the gas toward the outside of the planetary orbit inhibits the radial drift of dust, leading to dust accumulation (the dust ring). The outflow toward the inside of the planetary orbit enhances the inward drift of dust, causing dust depletion around the planetary orbit (the dust gap). Under weak turbulence ($α_{\rm diff}\lesssim10^{-4}$, where $α_{\rm diff}$ is the turbulence strength parameter), the gas flow induced by the planet with $\gtrsim1\,M_{\oplus}$ (Earth mass) generates the dust ring and gap in the distribution of small dust grains ($\lesssim1$ cm) with the radial extent of $\sim1\text{--}10$ times gas scale height around the planetary orbit without creating a gas gap and pressure bump. The gas flow induced by low-mass, non-gas-gap-opening planets can be considered a possible origin of the observed dust substructures in disks. Our results may be helpful to explain the disks whose dust substructures were found not to correlate with those of the gas.
description: 25 pages, 20 figures, Accepted for publication in Astronomy and Astrophysics (A&A)
Manipulating the orientation of an organic adsorbate on silicon: a NEXAFS study of acetophenone on Si(001)
Creators: name: O'Donnell, Kane M.
name: Warschkow, Oliver
name: Suleman, Asif
name: Fahy, Adam
name: Thomsen, Lars
name: Schofield, Steven R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We investigate the chemical and structural configuration of acetophenone on Si(001) using synchrotron radiation core-level spectroscopy techniques and density functional theory calculations. Samples were prepared by vapour phase dosing of clean Si(001) surfaces with acetophenone in ultrahigh vacuum. Near edge X-ray adsorption fine structure spectroscopy and photoelectron spectroscopy measurements were made at room temperature as a function of coverage density and post-deposition anneal temperature. We show that the dominant room temperature adsorption structure lies flat on the substrate, while moderate thermal annealing induces the breaking of Si-C bonds between the phenyl ring and the surface resulting in the reorientation of the adsorbate into an upright configuration.
description: 7 figures, 16 pages
Untangling the Galaxy. IV. Empirical Constraints on Angular Momentum Evolution and Gyrochronology for Young Stars in the Field
Creators: name: Kounkel, Marina
name: Stassun, Keivan G.
name: Bouma, Luke G.
name: Covey, Kevin
name: Hillenbrand, Lynne A.
name: Curtis, Jason Lee
Publisher: name: arXiv
Year: 2022
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present a catalog of ~100,000 periodic variable stars in TESS FFI data among members of widely distributed moving groups identified with Gaia in the previous papers in the series. By combining the periods from our catalog attributable to rotation with previously derived rotation periods for benchmark open clusters, we develop an empirical gyrochronology relation of angular momentum evolution that is valid for stars with ages 10-1000 Myr. Excluding stars rotating faster than 2 days, which we find are predominantly binaries, we achieve a typical age precision of ~0.2-0.3 dex and improving at older ages. Importantly, these empirical relations apply to not only FGK-type stars but also M-type stars, due to the angular momentum distribution being much smoother, simpler, continuous and monotonic as compared to the rotation period distribution. As a result, we are also able to begin tracing in fine detail the nature of angular momentum loss in low-mass stars as functions of mass and age. We characterize the stellar variability amplitudes of the cool stars as functions of mass and age, which may correlate with the starspot covering fractions. We also identify pulsating variables among the hotter stars in the catalog, including $δ$ Scuti, $γ$ Dor and SPB-type variables. These data represent an important step forward in being able to estimate precise ages of FGK- and M-type stars in the field, starting as early as the pre-main-sequence phase of evolution.
description: 24 pages, 14 figures, accepted to AJ
A Search for Unbound Stellar Companions to Pulsar J1124-5916
Creators: name: Kochanek, C. S.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We searched for and found no higher mass (>3Msun) unbound binary stellar companions to the progenitor of pulsar J1124-5916. There are lower mass candidates, but they all have high probabilities of being false positives. There are no candidates for it now being a fully unbound triple system. Even if one of the lower mass candidates is an unbound companion, it seems unlikely that it could have contributed to stripping the progenitor prior to the supernova. The stars are too low mass to be significant mass gainers, and they are too slowly moving to be the survivors of a compact, post-common envelope binary. The addition of one more system slightly improves the statistical constraints on the binary and triple status of supernova progenitors just before and after death.
description: submitted to MNRAS
Alle wollen Open Access, aber nicht alle setzen sich durch.
Creators: name: Dellmann, Sarah
Publisher: name: Zenodo
Year: 2024

description: Nationale und internationale Förderorganisationen, Hochschulleitungen und die HRK, Hochschulen und ihre Verbände auf diversen Kontinenten, Infrastruktureinrichtungen, Behörden und Regierungen in Bund und Ländern unter Koalitionen aller couleur, die UNESCO, Forscher*inInnen, Fachgesellschaften und Praktiker*inInnen, kommerzielle Großverlage und Grassroot-Initiativen: Alle wollen Open Access. Selbst Disziplinen und Verlage, die längere Zeit zurückhaltend waren, widmen sich nun dem Thema.

Bei einer solchen Einigkeit – so sollte man meinen – wird das gemeinsame Ziel schnell erreicht. Aber die Transformation scheint nicht in näherer Zukunft abgeschlossen zu sein. Wo stockt es?

Open Access, so Ausgangspunkt dieses Beitrags, wird von diversen Stakeholdern unterschiedlich definiert und aus unterschiedlichen, sich teils widersprechenden Motivationen verfolgt. Dieser Beitrag nimmt daher die Stakeholder und ihre Motivation unter die Lupe und zeigt, an welchen Stellen der vermeintliche Konsens eine Auseinandersetzung mit unterschiedlichen Interessen und Zielen erschwert - und wem es mehr und wem es weniger gelingt, eigene Interessen unter dem Label „Open Access“ durchzusetzen. Denn auch unter Wissenschaftler*inInnen und Studierenden als Hauptzielgruppen unserer Services gibt es teils sehr unterschiedliche Vorstellungen von guter Informationsversorgung.

Dieser Beitrag ist eine Ermunterung, die Steuerungswirkung bibliothekarischer Entscheidungen bewusster wahrzunehmen und die eigene Arbeit im wissenschaftspolitischen Feld einzuordnen: Letztlich sind keine unserer Entscheidungen „neutral“, jede Entscheidung über die Verwendung von Erwerbungsetats ist immer auch eine wissenschaftspolitische Entscheidung.

Erst, wenn uns klar ist, wo wir nicht einer Meinung sind, so meine Überzeugung, können wir uns als Bibliotheksmitarbeiter*inInnen, Wissenschaftler*inInnen und Publikationsdienstleistende klar für Ziele, daraus abgeleitete Strategien und, wo nötig, Kompromisse entscheiden.
Unmodified drug used as a material to construct nanoparticles: delivery of cisplatin for enhanced anti-cancer therapy
Creators: name: Miao, Lei
name: Huang, Leaf
name: Wang, Yuhua
name: Guo, Shutao
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The poor solubility of cisplatin (CDDP) often presents a major obstacle in the formulation of CDDP in nanoparticles (NPs) by traditional methods. We have developed a novel method for synthesizing CDDP NPs taking advantage of its poor solubility. By mixing two reverse microemulsions containing KCl and a highly soluble precursor of CDDP, cis-diaminedihydroplatinum (II), we have successfully formulated CDDP NPs with a controllable size (in the range of 12–75 nm) and high drug loading capacity (approximately 80 wt%). The formulation was done in two steps. The pure CDDP NPs were first stabilized for dispersion in an organic solvent by coating with 1, 2-dioleoyl-sn-glycero-3-phosphate (DOPA). Both x-ray photoelectron spectroscopy and 1H NMR data confirmed that the major ingredient of the DOPA-coated NPs was CDDP. After purification, additional lipids were added to stabilize the NPs for dispersion in an aqueous solution. The final NPs contain a lipid bilayer coating and are named Lipid-Pt-Cl (LPC) NPs, which showed significant antitumor activity both in vitro and in vivo. Thus, CDDP precipitate serves as the major material for assembling the novel NPs. This unique method of nanoparticle synthesis may be applicable in formulating other insoluble drugs.
Binary mergers in bootstrapped Newtonian gravity: mass gap and black hole area law
Creators: name: Casadio, Roberto
name: Kuntz, Iberê
name: Micu, Octavian
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We study binary mergers in bootstrapped Newtonian gravity, where higher-order couplings are added to the non-relativistic Lagrangian for the Newtonian potential. In this theory, the Arnowitt-Deser-Misner (ADM) mass differs from both the proper mass of Newtonian gravity and the proper mass of general relativity, which affects the interpretation of astrophysical and cosmological events. The aforementioned difference particularly provides important phenomenological constraints for the mass of the emitted matter and the compactness of the final object after the merger. The interpretation of the GW150914 signal in this theory also shows that LIGO's findings do not violate the mass gap, contrary to usual claims. We indeed find that typical stellar black hole masses can fit LIGO's data for a considerable range of compactness values. We calculate the black hole entropy in this context, which leads to a generalised black hole area law. Non-linear effects are found to effectively change only the gravitational strength via the renormalization of Newton's constant in this case.
description: 14 pages, 1 figure, to appear in Phys.Lett.B
Normal versus anomalous self-diffusion in two-dimensional fluids: Memory function approach and generalized asymptotic Einstein relation
Creators: name: Shin, Hyun Kyung
name: Choi, Bongsik
name: Talkner, Peter
name: Lee, Eok Kyun
Publisher: name: arXiv
Year: 2014
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Based on the generalized Langevin equation for the momentum of a Brownian particle a generalized asymptotic Einstein relation is derived. It agrees with the well-known Einstein relation in the case of normal diffusion but continues to hold for sub- and super-diffusive spreading of the Brownian particle's mean square displacement. The generalized asymptotic Einstein relation is used to analyze data obtained from molecular dynamics simulations of a two-dimensional soft disk fluid. We mainly concentrated on medium densities for which we found super-diffusive behavior of a tagged fluid particle. At higher densities a range of normal diffusion can be identified. The motion presumably changes to sub-diffusion for even higher densities.
The Recurrent Nova U Scorpii from the 2010.1 to 2022.4 Eruptions; the Missed Eruption of 2016.78 +- 0.10 and the Critical Complex Period Changes
Creators: name: Schaefer, Bradley E.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: U Sco is a recurrent nova with eleven observed eruptions, most recently in 2010.1 and 2022.4. I report on my program (running since 1989) of measuring eclipse times and brightnesses of U Sco in quiescence, from 2010 to 2022. The orbital period suddenly increased by +22.4 +- 1.0 parts-per-million across the 2010.1 eruption. This period change is greater than the near-zero period change (+3.9 +- 6.1 parts-per-million) across the 1999.2 eruption. This period change cannot come from any of the usual mechanisms, whereas the one remaining possibility is that the period changes are dominated by the little-known mechanism of the nova ejecting asymmetric shells. From 2010.1 to 2016.78, the O-C curve showed a steady period change that was large, with P-dot equal (-21.0 +- 3.2)X 10^-9. This is greatly higher than the steady period changes in the two previous inter-eruption intervals (-3.2 +- 1.9 and -1.1 +- 1.1 X 10^-9). This large, variable, and negative P-dot apparently comes from magnetic braking of the companion star's rotation. Starting in 2016.9 +- 0.6, the O-C curve showed a strong kink that is a unique characteristic of the sudden period change (+35.4 +- 7.1 parts-per-million) across a nova event. The brightness in quiescence after 2010.4 shows that the white dwarf accreted the trigger mass for the next nova event in the year 2017.1 +- 0.6. Photometric records show the only possible time for the eruption to peak (such that its total duration of 60 days was undetectable by any observation) is during a 75 day interval inside the 2016 solar gap, thus constraining the missed eruption to 2016.78 +- 0.10.
description: MNRAS submitted, 20 pages
Building Workflows for HTR to TEI Up-Conversion and Enhancement:The Evolving Hands Project
Creators: name: Cummings, James
name: Jakacki, Diane
name: Healey, Alexandra
name: Johnson, Ian
name: Pirmann, Carrie
name: Flex, Valentina
name: Jeffrey, Evie
Publisher: name: Zenodo
Year: 2023
Subjects: TEI XML
HTR
LEAF-Writer
LEAF-VRE

description: At the TEI2022 conference, we introduced the Evolving Hands project which was undertaking three case studies ranging across document forms to demonstrate how HTR-based workflows to develop TEI resources can be iteratively incorporated into curation. The case studies cover a wide range of textual forms, from handwritten work from the 19th-20th century UNESCO-recognised Gertrude Bell Archive of letters and diaries, or 20th century artistically-printed feminist zines, to highly structured and scholarly edited legacy printed material of the Records of Early English Drama (REED) project. The printed material used as samples are all in categories where using traditional OCR would result in a substantial loss of intellectual content. By covering a wide variety of periods and document forms the project wants to explore how best cultural institutions might use HTR to convert their collections into TEI files and then further approaches for up-conversion and enhancement of these into data-rich TEI editions. Across the varying case studies different approaches have been used, such as those who attempted to do as much tagging as possible in Transkribus’ online app, those who used LEAF-Writer to add enhancements liked named entity LOD, or those who processed the output with XSLT to preserve or enhance structured information before editing it further. This short paper will present some of the interim results of developing these workflows for converting HTR-processed text into TEI P5 XML and its further enhancement. Our goal in doing so is to pass on some of the insights and lessons learned during the development phase of the project, as well as to provide a starting point for further discussions and future collaborations in the field of HTR-based workflows for TEI curation. Ultimately, the project hopes to contribute to the ongoing development of best practices for using HTR for the creation of TEI editions.
Optimal entanglement-assisted discrimination of quantum measurements
Creators: name: Mikova, M.
name: Sedlak, M.
name: Straka, I.
name: Micuda, M.
name: Ziman, M.
name: Jezek, M.
name: Dusek, M.
name: Fiurasek, J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We investigate optimal discrimination between two projective single-qubit measurements in a scenario where the measurement can be performed only once. We consider general setting involving a tunable fraction of inconclusive outcomes and we prove that the optimal discrimination strategy requires an entangled probe state for any nonzero rate of inconclusive outcomes. We experimentally implement this optimal discrimination strategy for projective measurements on polarization states of single photons. Our setup involves a real-time electrooptical feed-forward loop which allows us to fully harness the benefits of entanglement in discrimination of quantum measurements. The experimental data clearly demonstrate the advantage of entanglement-based discrimination strategy as compared to unentangled single-qubit probes.
description: 7 pages, 6 figures
Microscopic approach to the evaluation of diffusion coefficients for substitutional f.c.c. solid solutions
Creators: name: Radchenko, T. M.
name: Tatarenko, V. A.
name: Bokoch, S. M.
name: Kulish, M. P.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The microscopic theory of atomic diffusion kinetics is used for f.c.c. substitutional solid solutions. Within this approach, the short-range order relaxation is due to the atomic migration. Experimental data on the time dependence of radiation diffuse scattering are used for the determination of microscopic characteristics of atomic migration. The model takes into account the discrete and anisotropic character of atomic jumps in a long-range field of the concentration heterogeneities of interacting atoms. Such a consideration is applied for a close-packed Ni-Fe solid solution. Atomic-jumps' probabilities are estimated that allows to determine the diffusion coefficients and activation energies. Independent kinetic experimental data about a time evolution of long-range order are also used to calculate diffusivities in L12-Ni-Fe alloy.
Homoeopathy a System of Holistic Healing as an Alternative Treatment for PCOS – a Review
Creators: name: DEEPTI DEWAN
name: Dr Rashmi Sharma
name: Dr Priyanka Nim
name: Dr Shweta Singh
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Medicine and Health Sciences
subject: PCOS, Review, Homoeopathy, Holistic healing, Rotterdam Criteria, Individualization

description: Polycystic ovarian syndrome (PCOS) is a complex hormonal and metabolic disorder characterized by oligomenorrhea or amenorrhea, hyperandrogenism and infertility. Global prevalence of PCOS is estimated to be between 06% and 26%. Homoeopathy, being a system of holistic healing can be accepted as one of the alternative treatments for PCOS. Aim & Objective: The aim of the study is to review clinical data, where the intervention was aimed to treat PCOS through Homoeopathy. The objective of the study is to identify the therapeutic approach, assessment criteria, treatment outcomes through an alternative therapy i.e., Homoeopathy in cases of PCOS. Methods: A systematic literature search was conducted in the month of June 2021 following International/National search databases for all clinical studies published in the period from 2000 to 2021. This search was aimed to target the entire literature of randomized trials or controlled trials, observational studies case studies/reports on PCOS in homoeopathy. Result:28 articles related to Homoeopathy on PCOS were identified. Out of these 28studies, 22 studies (01 RCT, 02 NRCT,06 observational studies,04 case series and 09 case reports) were included in this review. All studies were published in peer reviewed journals. Conclusions: To establish the evidence-based efficacy of the homoeopathic treatment in cases of RCT more pragmatic studies need to be planned in the future based on proper diagnostic criteria.
Inhomogeneous Cooling of the Rough Granular Gas in Two Dimensions
Creators: name: Pathak, Sudhir N.
name: Das, Dibyendu
name: Rajesh, R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We study the inhomogeneous clustered regime of a freely cooling granular gas of rough particles in two dimensions using large-scale event driven simulations and scaling arguments. During collisions, rough particles dissipate energy in both the normal and tangential directions of collision. In the inhomogeneous regime, translational kinetic energy and the rotational energy decay with time $t$ as power-laws $t^{-θ_T}$ and $t^{-θ_R}$. We numerically determine $θ_T \approx 1$ and $θ_R \approx 1.6$, independent of the coefficients of restitution. The inhomogeneous regime of the granular gas has been argued to be describable by the ballistic aggregation problem, where particles coalesce on contact. Using scaling arguments, we predict $θ_T=1$ and $θ_R=1$ for ballistic aggregation, $θ_R$ being different from that obtained for the rough granular gas. Simulations of ballistic aggregation with rotational degrees of freedom are consistent with these exponents.
description: 6 pages, 5 figures
L’Europa dei tradimenti. Il cosmopolitismo normativo europeo sotto attacco
Creators: name: Pendenza, Massimo
Publisher: name: Universita' degli Studi di Salerno
Year: 2017
Subjects: Europe
Cosmopolitanism
Normative-cosmopolitanism
Market-cosmopolitanism

description: The article aims to analyse the project of a cosmopolitan Europe and to show the validity not of its rejection, but rather, of its betrayal. My argument is that Europe has both historical and normative character-istics of a cosmopolitan kind. At the same time, Europe is also moving ‒due to the current economic-financial and immigration crisis ‒to-wards a cosmopolitanism of a different nature, which I call ‘market cosmopolitanism’, lacking any internal or external solidarity yet already embedded in the European Union constitutional project. In particular, I intend to develop the following three arguments: 1. that Europe can be considered a more specific historic space of potential affirmation of cosmopolitanism, resting on the principles and respect for the dignity of individuals and peoples; 2. that what I call the ‘normative cosmopol-itan’ project of Europe can be traced in the articles of the Constitu-tional Treaties and the Charter of the European fundamental rights; 3. finally, that the betrayal of the aimsof such project has been provoked by the alternative European project of ‘marketcosmopolitanism’.
A radio-theranostic nanoparticle with high specific drug loading for cancer therapy and imaging
Creators: name: Huang, Leaf
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: We have developed a theranostic nanoparticle delivering the model radionuclide (177)Lu based on the versatile lipid-calcium-phosphate (LCP) nanoparticle delivery platform. Characterization of (177)Lu-LCP has shown that radionuclide loading can be increased by several orders of magnitude without affecting the encapsulation efficiency or the morphology of (177)Lu-LCP, allowing consistency during fabrication and overcoming scale-up barriers typical of nanotherapeutics. The choice of (177)Lu as a model radionuclide has allowed in vivo anticancer therapy in addition to radiographic imaging via the dual decay modes of (177)Lu. Tumor accumulation of (177)Lu-LCP was measured using both SPECT and Cerenkov imaging modalities in live mice, and treatment with just one dose of (177)Lu-LCP showed significant in vivo tumor inhibition in two subcutaneous xenograft tumor models. Microenvironment and cytotoxicity studies suggest that (177)Lu-LCP inhibits tumor growth by causing apoptotic cell death via double-stranded DNA breaks while causing a remodeling of the tumor microenvironment to a more disordered and less malignant phenotype.
Time-Varying Multivariate Causal Processes
Creators: name: Gao, Jiti
name: Peng, Bin
name: Wu, Wei Biao
name: Yan, Yayi
Publisher: name: Monash University
Year: 2022
Subjects: Econometric and statistical methods
Econometrics not elsewhere classified

description: In this paper, we consider a wide class of time-varying multivariate causal processes that nests many classical and new examples as special cases. We first prove the existence of a weakly dependent stationary approximation for our model which is the foundation to initiate the theoretical development. Afterwards, we consider the QMLE estimation approach, and provide both point-wise and simultaneous inferences on the coefficient functions. In addition, we demonstrate the theoretical findings through both simulated and real data examples. In particular, we show the empirical relevance of our study using an application to evaluate the conditional correlations between the stock markets of China and U.S. We find that the interdependence between the two stock markets is increasing over time.
title: Corporate social responsibility in higher education: concept, content, improvement
Creators: name: He, Sijin
Publisher: name: University of Glasgow
Year: 2023

description: This research aims to explore the key concepts, main content, and central areas of improvements in CSR in the HE sector. Regarding this, three research questions were formulated: (1) What CSR activities are currently implemented in the HE sector? (2) What aspects of CSR should be covered in the HE sector from the stakeholders’ perspective? (3) How can CSR performance be improved in the HE sector? In research fieldwork, interview method was adopted for collecting data from 54 participants (incl. 17 HEI policymakers/executives, 17 academics, and 20 student representatives) from 20 different HEIs in China and in the UK. The data collected from these participants were analysed through thematic analysis in the forms of narrative text, thematic map, and statistical table. By discussing the findings of the data analysis, contributions were made to both theoretical development and practice. The main theoretical contribution of this research was exploring what CSR means in HE context. Other theoretical contributions made by this research include identifying characteristics of CSR in the HE sector; adding ‘instrumental aspects’ and ‘political aspects’ to explain CSR in this sector; and specifying the linkage of SDGs with CSR in the context of HE. Practical implications were made in considering the aspects of CSR in the HE sector to better serve the interests of HEI’s stakeholders. This involved taking a path to improvement of CSR performance in the HE sector, and developing CSR strategy in terms of managing the quality of CSR activities.
Fluctuation Spectroscopy: A New Probe of Old Stellar Populations
Creators: name: van Dokkum, Pieter
name: Conroy, Charlie
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We introduce a new method to determine the relative contributions of different types of stars to the integrated light of nearby early-type galaxies. As is well known, the surface brightness of these galaxies shows pixel-to-pixel fluctuations due to Poisson variations in the number of giant stars. Differential spectroscopy of pixels as a function of fluctuation strength ("fluctuation spectroscopy") effectively measures the spectral variation of stars as a function of their luminosity, information that is otherwise difficult to obtain for individual stars outside of the Local Group. We apply this technique to the elliptical galaxy NGC 4472, using HST/ACS imaging in six narrow-band ramp filters tuned to spectral features in the range 0.8-1.0 micron. Pixels with +- 5% broad-band variations show differential color variations of 0.1% - 1.0% in the narrow-band filters. These variations are primarily due to the systematic increase in TiO absorption strength with increasing luminosity on the upper giant branch. The data are very well reproduced by the same Conroy & van Dokkum (2012) stellar population synthesis model that is the best fit to the integrated light, with residuals in the range 0.03% - 0.09%. Models with ages or metallicities that are significantly different from the integrated-light values do not yield good fits. We can also rule out several modifications to the underlying model, including the presence of a significant (>3% of the light) population of late M giants. The current observations constitute a powerful test of the expected luminosities and temperatures of metal-rich giants in massive early-type galaxies. Studies of pixels with much larger (negative) fluctuations will provide unique information on main sequence stars and the stellar initial mass function.
description: Accepted for publication in the Astrophysical Journal. 19 pages, 22 figures. Fig. 1 illustrates the concept; Fig. 16 is the key science plot