cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Mutations in phospholipase C eta-1 ( PLCH1 ) are associated with holoprosencephaly
Creators: name: Drissi, Ichrak
name: Fletcher, Emily
name: Shaheen, Ranad
name: Nahorski, Michael
name: Alhashem, Amal M
name: Lisgo, Steve
name: Fernández-Jaén, Alberto
name: Schon, Katherine
name: Tlili-Graiess, Kalthoum
name: Smithson, Sarah F
name: Lindsay, Susan
name: J Sharpe, Hayley
name: Alkuraya, Fowzan S
name: Woods, Geoff
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Neurogenetics
1506
cerebellar diseases
congenital
hereditary
and neonatal diseases and abnormalities
genetics
mutation

description: Funder: NIHR Cambridge Biomedical Research centre
description: Background: Holoprosencephaly is a spectrum of developmental disorder of the embryonic forebrain in which there is failed or incomplete separation of the prosencephalon into two cerebral hemispheres. To date, dominant mutations in sonic hedgehog (SHH) pathway genes are the predominant Mendelian causes, and have marked interfamilial and intrafamilial phenotypical variabilities. Methods: We describe two families in which offspring had holoprosencephaly spectrum and homozygous predicted-deleterious variants in phospholipase C eta-1 (PLCH1). Immunocytochemistry was used to examine the expression pattern of PLCH1 in human embryos. We used SHH as a marker of developmental stage and of early embryonic anatomy. Results: In the first family, two siblings had congenital hydrocephalus, significant developmental delay and a monoventricle or fused thalami with a homozygous PLCH1 c.2065C>T, p.(Arg689*) variant. In the second family, two siblings had alobar holoprosencephaly and cyclopia with a homozygous PLCH1 c.4235delA, p.(Cys1079ValfsTer16) variant. All parents were healthy carriers, with no holoprosencephaly spectrum features. We found that the subcellular localisation of PLCH1 is cytoplasmic, but the p.(Cys1079ValfsTer16) variant was predominantly nuclear. Human embryo immunohistochemistry showed PLCH1 to be expressed in the notorcord, developing spinal cord (in a ventral to dorsal gradient), dorsal root ganglia, cerebellum and dermatomyosome, all tissues producing or responding to SHH. Furthermore, the embryonic subcellular localisation of PLCH1 was exclusively cytoplasmic, supporting protein mislocalisation contributing to the pathogenicity of the p.(Cys1079ValfsTer16) variant. Conclusion: Our data support the contention that PLCH1 has a role in prenatal mammalian neurodevelopment, and deleterious variants cause a clinically variable holoprosencephaly spectrum phenotype.
Frozen Orbits at high eccentricity and inclination: Application to Mercury orbiter
Creators: name: Delsate, N.
name: Robutel, P.
name: Lemaitre, A.
name: Carletti, T.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We hereby study the stability of a massless probe orbiting around an oblate central body (planet or planetary satellite) perturbed by a third body, assumed to lie in the equatorial plane (Sun or Jupiter for example) using an Hamiltonian formalism. We are able to determine, in the parameters space, the location of the frozen orbits, namely orbits whose orbital elements remain constant on average, to characterize their stability/unstability and to compute the periods of the equilibria. The proposed theory is general enough, to be applied to a wide range of probes around planet or natural planetary satellites. The BepiColombo mission is used to motivate our analysis and to provide specific numerical data to check our analytical results. Finally, we also bring to the light that the coefficient J_2 is able to protect against the increasing of the eccentricity due to the Kozai-Lidov effect.
description: 26 pages, 14 figures
Anzeige der Berufung von Joseph Wolfgang von Deschwanden (1819-1866) durch den Bundesrat, zum Professor der darstellenden Geometrie an der eidgenössischen polytechnischen Schule in Zürich, mitgeteilt durch den Schweizerischen Schulrat
Creators: name: Schule, Eidgenössische Polytechnische, Behörden, Lehrkörper und Verwaltung
Publisher: name: [s.n.]
Year: 1855

description: Mitteilung der Berufung am 24.3.1855 und Übertragung der Leitung des Vorbereitungskurses an J. W. von Deschwanden.
Unterzeichnet von Johann Konrad Kern (1808-1888), Präsident des Schweiz. Schulrats, und von Johann Gustav Stocker (1820-1889), Sekretär
Fast minimum variance wavefront reconstruction for extremely large telescopes
Creators: name: Thiebaut, Eric
name: Tallon, Michel
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We present a new algorithm, FRiM (FRactal Iterative Method), aiming at the reconstruction of the optical wavefront from measurements provided by a wavefront sensor. As our application is adaptive optics on extremely large telescopes, our algorithm was designed with speed and best quality in mind. The latter is achieved thanks to a regularization which enforces prior statistics. To solve the regularized problem, we use the conjugate gradient method which takes advantage of the sparsity of the wavefront sensor model matrix and avoids the storage and inversion of a huge matrix. The prior covariance matrix is however non-sparse and we derive a fractal approximation to the Karhunen-Loeve basis thanks to which the regularization by Kolmogorov statistics can be computed in O(N) operations, N being the number of phase samples to estimate. Finally, we propose an effective preconditioning which also scales as O(N) and yields the solution in 5-10 conjugate gradient iterations for any N. The resulting algorithm is therefore O(N). As an example, for a 128 x 128 Shack-Hartmann wavefront sensor, FRiM appears to be more than 100 times faster than the classical vector-matrix multiplication method.
description: to appear in the Journal of the Optical Society of America A
Comparing associations between sexual function, sexual distress, and psychological symptoms in women with and without sexual function difficulties
Creators: name: Kolbuszewska, Marta
Publisher: name: University of British Columbia
Year: 2023

description: Anxiety and depressive symptoms, as well as anxiety and depressive disorders, are highly comorbid with sexual dysfunction (i.e., persistent distressing problems with sexual desire, arousal, orgasm, and pain) in women; however, little research has examined this comorbidity at the symptom level, or how it may differ for women with versus without sexual function problems. The present research used network analysis to compare how dimensions of sexual function (i.e., orgasm, satisfaction, lubrication, arousal, desire, pain), sexual distress, and anxiety and depressive symptoms relate to one another in women with (N = 150) and without (N = 575) sexual function problems. For both women with and without sexual function problems, arousal was particularly central. Additionally, somatic symptoms (e.g., tension, cardiovascular symptoms) were central to the networks of anxiety and sexual function symptoms while sadness and anhedonia were central to the networks of depression and sexual function symptoms. We found no differences in the density of symptom networks for women with versus without sexual function problems. In sum, the current study uses network analysis to provide a novel examination of associations between sexual function, sexual distress, and psychological symptoms, as well as how these associations differ in women with and without clinically significant problems with sexual function.
Superconducting nanowire single photon detectors for quantum information and communications
Creators: name: Wang, Zhen
name: Miki, Shigehito
name: Fujiwara, Mikio
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Physics (quant-ph)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Superconducting nanowire single photon detectors (SNSPD or SSPD) are highly promising devices in the growing field of quantum information and communications technology. We have developed a practical SSPD system with our superconducting thin films and devices fabrication, optical coupling packaging, and cryogenic technology. The SSPD system consists of six-channel SSPD devices and a compact Gifford-McMahon (GM) cryocooler, and can operate continuously on 100 V ac power without the need for any cryogens. The SSPD devices were fabricated from high-quality niobium nitride (NbN) ultra-thin films that were epitaxially grown on single-crystal MgO substrates. The packaged SSPD devices were temperature stabilized to 2.96 K +/- 10 mK. The system detection efficiency for an SSPD device with an area of 20x20 $μm^2$ was found to be 2.6% and 4.5% at wavelengths of 1550 and 1310 nm, respectively, at a dark count rate of 100 c/s, and a jitter of 100 ps full width at half maximum (FWHM). We also performed ultra-fast BB84 quantum key distribution (QKD) field testing and entanglement-based QKD experiments using these SSPD devices.
description: 7 pages, 10 figures
On Classical de Sitter Vacua in String Theory
Creators: name: Wrase, Timm
name: Zagermann, Marco
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We review the prospect of obtaining tree-level de Sitter (dS) vacua and slow-roll inflation models in string compactifications. Restricting ourselves to the closed string sector and assuming the absence of NSNS-sources, we classify the minimal classical ingredients that evade the simplest no-go theorems against dS vacua and inflation. Spaces with negative integrated curvature together with certain combinations of low-dimensional orientifold planes and low-rank RR-fluxes emerge as the most promising setups of this analysis. We focus on two well-controlled classes that lead to an effective 4D, N=1 supergravity description: Type IIA theory on group or coset manifolds with SU(3)-structure and O6-planes, as well as type IIB compactifications on SU(2)-structure manifolds with O5- and O7-planes. While fully stabilized AdS vacua are generically possible, a number of problems encountered in the search for dS vacua are discussed.
description: 4 pages, proceedings of the 9th Hellenic School on Elementary Particle Physics and Gravity, Corfu 2009
Gribov horizon and BRST symmetry: a pathway to confinement
Creators: name: Sorella, S. P.
name: Baulieu, L.
name: Dudal, D.
name: Guimaraes, M. S.
name: Huber, M. Q.
name: Vandersickel, N.
name: Zwanziger, D.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We summarize the construction of the Gribov-Zwanziger action and how it leads to a scenario which explains the confinement of gluons, in the sense that the elementary gluon excitations violate positivity. Then we address the question of how one can construct operators within this picture whose one-loop correlation functions have the correct analytic properties in order to correspond to physical excitations. For this we introduce the concept of i-particles.
description: 5 pages, proceedings of XII Mexican Workshop on Particles and Fields 2009
Mietvertrag, ausgestellt von J. A. Ottiker in Oberstrass, zuhanden von Joseph Wolfgang von Deschwanden (1819-1866)
Creators: name: Ottiker, J. A.
Publisher: name: [s.n.]
Year: 1858

description: Handschriftlicher Vertrag betr. Vermietung einer 6-Zimmer-Wohnung in der dritten Etage, mit dem Zins von 800 Franken jährlich, unterzeichnet von J. A. Ottiker in Oberstrass
Anticoagulation trends in adults aged 65 years and over with atrial fibrillation: a cohort study
Creators: name: Lund, Jenny
name: Saunders, Catherine L
name: Edwards, Duncan
name: Mant, Jonathan
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Arrhythmias and sudden death
1506
anticoagulation
atrial fibrillation
epidemiology

description: Objective: To describe patterns of anticoagulation prescription and persistence for those aged ≥65 years with atrial fibrillation (AF). Methods: Descriptive cohort study using electronic general practice records of patients in England, who attended an influenza vaccination aged ≥65 years and were diagnosed with AF between 2008 and 2018. Patients were stratified by 10-year age group and year of diagnosis. Proportion anticoagulated, type of anticoagulation (direct oral anticoagulant (DOAC) or warfarin) initiated at diagnosis and persistence with anticoagulation over time are reported. Results: 42 290 patients (49% female), aged 65–74 (n=11 722), 75–84 (n=19 055) and 85+ (n=11 513) years at AF diagnosis are included. Prescription of anticoagulation at diagnosis increased over the time period from 55% to 86% in people aged 65–74 years, from 54% to 86% in people aged 75–84 years and from 27% to 75% in people aged 85 years and over. By 2018, 92% of patients with newly diagnosed AF were started on a DOAC. Survivor function for 5-year persistence in patients prescribed DOAC was 0.80 (95% CI 0.77 to 0.82) and for warfarin 0.71 (95% CI 0.70 to 0.72). Survivor function for any anticoagulation at 5 years was 0.79 (95% CI 0.78 to 0.81), 0.73 (95% CI 0.72 to 0.75) and 0.58 (95% CI 0.59 to 0.64) for people aged 65–74, 75–84 and 85+ years, respectively. Conclusions: Rates of anticoagulation in AF in those aged ≥65 years have increased from 2008 to 2018, over which time period there has been a shift from initiating anticoagulation with warfarin to DOAC. Persistence with anticoagulation is higher in people on DOACs than on warfarin and in people aged <85 years.
From Patañjali to the “Gospel of Sweat”: Yoga’s Remarkable Transformation from a Sacred Movement into a Thriving Global Market
Creators: name: Munir, Kamal
name: Ansari, Shahzad (Shaz)
name: Brown, Deborah
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Articles
social movements
moral markets
commodification
commensuration
values
morality
yoga

description: Movements seeking to infuse markets with moral values often end up utilizing the market mechanism and support from mainstream actors to scale up, even if it comes at the cost of diluting their founding ethos. But this process can be particularly challenging for movements that are explicitly opposed to using a market mechanism as a means of scaling up. Our analysis of yoga between 1975 and 2016 reveals how a countercultural movement fundamentally opposed to a capitalist market economy but seeking to grow can paradoxically become syncretic with or infiltrated by concepts and beliefs that are core to the market system but incompatible with the movement’s original ethos. We show how, before such a movement can be commodified, it must be de-essentialized, a process that requires stripping away key aspects of its history, context, and religious commitments and transforming collective goals into individual ones. This process involves not only external entrepreneurs looking to mine the movement but also movement leaders seeking wider enrollment of resource-rich actors to scale the movement up. We show how codes borrowed from parallel movements and templates borrowed from markets can be instrumental in driving such a movement’s transformation. Through this extreme case of the yoga movement, we advance understandings of how movements can become syncretic with values and practices they fundamentally oppose.
Die Wohntopographie des preußischen Hofes und seiner Nachbarn im 19. Jahrhundert. Daten und Visualisierung
Creators: name: Bittner, Anja
name: Große, Annelie
name: Klappenbach, Lou
name: Wierzoch, Jan
Publisher: name: Zenodo
Year: 2023
Subjects: Kartenvisualisierung, Digital Humanities, Digital History, Geodaten

description: Das im Rahmen der Digital History Tagung 2023 veröffentlichte Poster stellt das Projekt "Wohntopographie" des Akademienvorhabens „Anpassungsstrategien der späten mitteleuropäischen Monarchie am preußischen Beispiel 1786-1918“ und der DH-Abteilung TELOTA der Berlin-Brandenburgischen Akademie der Wissenschaften vor. Die Wohntopographie stellt die Wohnorte von Mitgliedern des preußischen Königshofes und ihrer Nachbarn während des 19. Jahrhunderts dar, um so mit Hilfe digitaler Methoden die räumlich-soziale Integration des preußischen Hofe im Berlin des 19. Jahrhunderts zu untersuchen und mögliche Kontaktpunkte und Verflechtungen zwischen Hof und Berliner Stadtgesellschaft abzubilden. Das Poster betrachtet den Ablauf und die Innovationspotenzial der dazu erstellten Geodaten und ihrer webbasierten Kartenvisualisierung gegenüber statischen Datenvisualisierungen in den Geschichtswissenschaften. Die Wohntopographie versteht sich als Teil einer aktuellen Entwicklung in den DH, in der vermehrt Projekte entstehen, die sich durch Offenheit der Daten sowie Interaktivität auszeichnen
Hexaquarks in the coupled-channel formalism
Creators: name: Gerasyuta, S. M.
name: Matskevich, E. E.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The relativistic six-quark equations are found in the framework of the dispersion relation technique. The approximate solutions of these equations using the method based on the extraction of leading singularities of the amplitudes are obtained. The relativistic six-quark amplitudes of hexaquarks including the quarks of three flavors ($u$, $d$, $s$) are calculated. The poles of these amplitudes determine the masses of six-quark systems.
description: 24 pages, latex
The small-scale solar surface dynamo
Creators: name: Graham, Jonathan Pietarila
name: Danilovic, Sanja
name: Schuessler, Manfred
Publisher: name: arXiv
Year: 2010
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The existence of a turbulent small-scale solar surface dynamo is likely, considering existing numerical and laboratory experiments, as well as comparisons of a small-scale dynamo in MURaM simulations with Hinode observations. We find the observed peaked probability distribution function (PDF) from Stokes-V magnetograms is consistent with a monotonic PDF of the actual vertical field strength. The cancellation function of the vertical flux density from a Hinode SP observation is found to follow a self-similar power law over two decades in length scales down to the ~200 km resolution limit. This provides observational evidence that the scales of magnetic structuring in the photosphere extend at least down to 20 km. From the power law, we determine a lower bound for the true quiet-Sun mean vertical unsigned flux density of ~43 G, consistent with our numerically-based estimates that 80% or more of the vertical unsigned flux should be invisible to Stokes-V observations at a resolution of 200 km owing to cancellation. Our estimates significantly reduce the order-of-magnitude discrepancy between Zeeman- and Hanle-based estimates.
description: Proceedings of the Second Hinode Science Meeting, ASP Series 2009. 8 pages, 4 figures
Quantitative Checklist for Autism in Toddlers (Q-CHAT). A population screening study with follow-up: the case for multiple time-point screening for autism
Creators: name: Allison, Carrie
name: Matthews, Fiona E
name: Ruta, Liliana
name: Pasco, Greg
name: Soufer, Renee
name: Brayne, Carol
name: Charman, Tony
name: Baron-Cohen, Simon
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Screening
1506
autism
screening

description: Funder: Autism Research Trust
description: Funder: National Lottery Community Fund; FundRef: http://dx.doi.org/10.13039/501100013529
description: Funder: Collaboration for Leadership in Applied Health Research and Care (CLAHRC)
description: Objective: This is a prospective population screening study for autism in toddlers aged 18–30 months old using the Quantitative Checklist for Autism in Toddlers (Q-CHAT), with follow-up at age 4. Design: Observational study. Setting: Luton, Bedfordshire and Cambridgeshire in the UK. Participants: 13 070 toddlers registered on the Child Health Surveillance Database between March 2008 and April 2009, with follow-up at age 4; 3770 (29%) were screened for autism at 18–30 months using the Q-CHAT and the Childhood Autism Spectrum Test (CAST) at follow-up at age 4. Interventions: A stratified sample across the Q-CHAT score distribution was invited for diagnostic assessment (phase 1). The 4-year follow-up included the CAST and the Checklist for Referral (CFR). All with CAST ≥15, phase 1 diagnostic assessment or with developmental concerns on the CFR were invited for diagnostic assessment (phase 2). Standardised diagnostic assessment at both time-points was conducted to establish the test accuracy of the Q-CHAT. Main outcome measures: Consensus diagnostic outcome at phase 1 and phase 2. Results: At phase 1, 3770 Q-CHATs were returned (29% response) and 121 undertook diagnostic assessment, of whom 11 met the criteria for autism. All 11 screened positive on the Q-CHAT. The positive predictive value (PPV) at a cut-point of 39 was 17% (95% CI 8% to 31%). At phase 2, 2005 of 3472 CASTs and CFRs were returned (58% response). 159 underwent diagnostic assessment, including 82 assessed in phase 1. All children meeting the criteria for autism identified via the Q-CHAT at phase 1 also met the criteria at phase 2. The PPV was 28% (95% CI 15% to 46%) after phase 1 and phase 2. Conclusions: The Q-CHAT can be used at 18–30 months to identify autism and enable accelerated referral for diagnostic assessment. The low PPV suggests that for every true positive there would, however, be ~4–5 false positives. At follow-up, new cases were identified, illustrating the need for continued surveillance and rescreening at multiple time-points using developmentally sensitive instruments. Not all children who later receive a diagnosis of autism are detectable during the toddler period.
title: Aluminium is Now Critical – Enabling UNFC-Compliant Classification for a German Aluminium Scrap Recovery Project
Creators: name: von Vietinghoff-Scheel, Marina
name: Korf, Nathalie
name: Greb, Thorsten
name: Rotter, Vera Susanne
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
The United Nations Framework Classification for Resources (UNFC) is an assessment tool for mineral resource endowments, originally developed for side-projects concerning geogenic resources, such as mines. Given the integration of UNFC into the Critical Raw Material Act, it is crucial to develop a standardized classification method for secondary raw materials. However, the current framework lacks concrete guidance and primarily relies on mining sector definitions. This leads to the inconsistent use of various factors and methods in case studies, resulting in diminished comparability. To understand the requirements and challenges of the application on secondary raw material projects and address the recent assessment of aluminium as critical, a pioneering case study is conducted on a novel aluminium sorting plant using laser-induced-breakdown-spectroscopy to enable alloy specific sorting of old scrap.

The UNFC assessment bases on three criteria: "Environmental-Socio-Economic Viability," "Technical Feasibility," and "Degree of Confidence in the Estimate”. In this study the criteria are evaluated with newly developed and existing factors such as quantity, quality, supply continuity, technology, infrastructure, and socio-economic, legal and environmental aspects, using assessment methods like technology readiness level and material flow analysis. This results in a concrete guidance covering data demand, data sources and assessment tools.

The study's results will highlight the distinct requirements that differ from those of the mining sector and contribute to the development of a modified methodology. These advancements aim to enhance the applicability of UNFC, enabling comprehensive evaluations of different types of resources and projects and promoting informed decision-making towards a circular economy.
Internal Heating of Old Neutron Stars: Contrasting Different Mechanisms
Creators: name: Gonzalez, Denis
name: Reisenegger, Andreas
name: Fernandez, Rodrigo
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The thermal emission detected from the millisecond pulsar J0437-4715 is not explained by standard cooling models of neutron stars without a heating mechanism. We investigated three heating mechanisms controlled by the rotational braking of the pulsar: breaking of the solid crust, superfluid vortex creep, and non-equilibrium reactions ('rotochemical heating'). We find that the crust cracking mechanism does not produce detectable heating. Given the dependence of the heating mechanisms on spin-down parameters, which leads to different temperatures for different pulsars, we study the thermal evolution for two types of pulsars: young, slowly rotating 'classical' pulsars and old, fast rotating millisecond pulsars (MSPs). We find that the rotochemical heating and vortex creep mechanism can be important both for classical pulsars and MSPs.
description: VIII Symposium in Nuclear Physics and Applications: Nuclear and Particle Astrophysics. Appearing in the American Institute of Physics (AIP) conference proceedings
Acoustic resonances in two dimensional radial sonic crystals shells
Creators: name: Torrent, Daniel
name: Sánchez-Dehesa, José
Publisher: name: arXiv
Year: 2010
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Radial sonic crystals (RSC) are fluidlike structures infinitely periodic along the radial direction. They have been recently introduced and are only possible thanks to the anisotropy of specially designed acoustic metamaterials [see Phys. Rev. Lett. {\bf 103} 064301 (2009)]. We present here a comprehensive analysis of two-dimensional RSC shells, which consist of a cavity defect centered at the origin of the crystal and a finite thickness crystal shell surrounded by a fluidlike background. We develop analytic expressions demonstrating that, like for other type of crystals (photonic or phononic) with defects, these shells contain Fabry-Perot like resonances and strongly localized modes. The results are completely general and can be extended to three dimensional acoustic structures and to their photonic counterparts, the radial photonic crystals.
Erneuerung der Wahl von Joseph Wolfgang von Deschwanden (1819-1866) zum Mitglied der Aufsichtskommission der Industrieschule Zürich, beschlossen durch den Direktor des Erziehungswesens und durch den Erziehungsrat des Kantons Zürich
Creators: name: Zürich: Kanton: Erziehungsdirektion des Kantons Zürich
Publisher: name: [s.n.]
Year: 1858

description: Auszug des Beschlusses, 13.7.1858 in Zürich, zuhanden von J. W. von Deschwanden.
Unterzeichnet durch den Direktor des Erziehungswesens, Jakob Dubs (1822-1879), und den Sekretär des Erziehungsrates, Friedrich Schweizer (1816-1899)
Discovery and surveillance of viral spillover threats using probe capture-based targeted genomic sequencing
Creators: name: Kuchinski, Kevin Stephen
Publisher: name: University of British Columbia
Year: 2023

description: Human health and agriculture are constantly threatened by viruses that spillover from wildlife. Genomic sequencing is becoming integral to protecting humanity from these threats. This technology is being used to explore viral biodiversity and identify new potential pathogens. It is also being used to monitor human, livestock, and wildlife populations for potential spillovers. Recovering and analyzing viral genomes in real-world specimens remains a challenge, however. Viral genomic material must be recovered from human, animal, and environmental specimens where it is extremely dilute, fragmented, or incomplete. This makes enrichment of viral genomic material necessary for practical, high-throughput surveillance operations. Hybridization probe capture is a powerful technique used in many fields to enrich target genomic material when preparing specimens for sequencing. This technique uses synthetic nucleotide oligomers (probes) to capture target genomic fragments while background material is washed away. To achieve this, collections of probes must be designed with sequences complementary to the target genome, which becomes problematic for viral targets with extensive genetic diversity and hypervariability. Designing compact probe panels that provide broad coverage of viral taxa presents a substantial computational challenge. A lack of accessible probe design tools has kept this powerful technique out of reach for many public health and agriculture agencies. Consequently, probe capture has not been widely deployed for large-scale discovery and routine surveillance of viral spillover threats. To address this gap, this dissertation presents ProbeTools, a user-friendly software package developed to facilitate probe panel design for diverse and hypervariable viral taxa. In this dissertation, ProbeTools is validated in silico on tens of thousands of reference genome sequences and in vitro on dozens of egg-cultured viral isolates. Next, ProbeTools is applied to two real-world viral discovery and surveillance applications. First, it is used to characterize genomes of novel coronaviruses in bats. Second, it is used to detect avian influenza viruses in environmental specimens from wild bird habitats. The validations and case studies in this dissertation demonstrate the power of probe capture for discovery and surveillance of viral spillover threats. They also demonstrate the suitability and flexibility of ProbeTools when designing probe panels for applied viral genomics.
Map #109, Site 5MT10711, Pithouse 101-103, Surface 2
Creators: name: DeVos, Jim
Year: 2018
Subjects: subject: Southwestern Colorado
valueUri: https://core.tdar.org/browse/geographic-keyword/2810/southwestern-colorado
subject: Southwestern US
valueUri: https://core.tdar.org/browse/geographic-keyword/84604/southwestern-us
subject: Basketmaker III
valueUri: https://core.tdar.org/browse/temporal-keyword/78/basketmaker-iii
subject: 5MT10711
valueUri: https://core.tdar.org/browse/site-name/118032/5mt10711
subject: Ridgeline Site
valueUri: https://core.tdar.org/browse/site-name/118031/ridgeline-site

description: Site 5MT10711, Pithouse 101-103, Surface 2
Early adulthood socioeconomic trajectories contribute to inequalities in adult cardiovascular health, independently of childhood and adulthood socioeconomic position
Creators: name: Winpenny, Eleanor M
name: Howe, Laura D
name: Van Sluijs, Esther M F
name: Hardy, Rebecca
name: Tilling, Kate
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Original research
1506
inequalities
blood pressure
cardiovascular diseases
life course epidemiology
social epidemiology

description: Background: Cardiovascular health shows significant socioeconomic inequalities, however there is little understanding of the role of early adulthood in generation of these inequalities. We assessed the contribution of socioeconomic trajectories during early adulthood (16–24 years) to cardiovascular health in mid-adulthood (46 years). Methods: Participants from the 1970 British Cohort Study with socioeconomic data available in early adulthood were included (n=12 423). Longitudinal latent class analysis identified socioeconomic trajectories, based on patterns of economic activity throughout early adulthood. Cardiometabolic risk factors (46 years) were regressed on socioeconomic trajectory class (16–24 years), testing mediation by adult socioeconomic position (46 years). Models were stratified by sex and adjusted for childhood socioeconomic position (SEP) and adolescent health. Results: Six early adulthood socioeconomic trajectories were identified: (1) Continued Education (20.2%), (2) Managerial Employment (16.0%), (3) Skilled Non-manual Employment (20.9%), (4) Skilled Manual Employment (18.9%), (5) Partly Skilled Employment (15.8%) and (6) Economically Inactive (8.1%). The ‘Continued Education’ trajectory class showed the best cardiovascular health at age 46 years, with the lowest levels of cardiometabolic risk factors. For example, systolic blood pressure was 128.9 mm Hg (95% CI 127.8 to 130.0) among men in the ‘Continued Education’ class, compared with 131.3 mm Hg (95% CI 130.4 to 132.2) among men in the ‘Skilled Manual’ class. Patterns across classes 2–6 differed by risk factor and sex. The observed associations were largely not mediated by SEP at age 46 years. Conclusion: Findings suggest an independent contribution of early adulthood socioeconomic trajectories to development of later life cardiovascular inequalities. Further work is needed to understand mediators of this relationship and potential for interventions to mitigate these pathways.
Joseph Wolfgang von Deschwanden (1819-1866) an den Präsidenten des Handwerks- und Gewerbeverein des Bezirks Zürich, Briefkonzept
Creators: name: Deschwanden, Joseph Wolfgang von
Publisher: name: [s.n.]
Year: 1858

description: Entwurf, datiert 12.12.1858 in Zürich, mit Dank an den Präsidenten J. Ch. Paur für die Ernennung zum Ehrenmitglied des Handwerks- und Gewerbevereins
Amtliche Mitteilungen der Technischen Universität Dortmund Nr. 9/2019
Creators: name: (:Unkn) Unknown
Publisher: name: Technische Universität Dortmund
Year: 2019
Subjects: subject: 080

description: Gleichstellungskonzept der Technischen Universität Dortmund 2017 bis 2021
description: Benutzungsordnung für die Sportanlagen der Technischen Universität Dortmund (Innen- und Außenanlagen)
description: Amtliche Mitteilungen der Technischen Universität Dortmund;2019,9
Wahl von Joseph Wolfgang von Deschwanden (1819-1866) zum Mitglied der Aufsichtskommission der Industrieschule Zürich, beschlossen durch den Direktor des Erziehungswesens und durch den Erziehungsrat des Kantons Zürich
Creators: name: Zürich: Kanton: Erziehungsdirektion des Kantons Zürich
Publisher: name: [s.n.]
Year: 1855

description: Auszug des Beschlusses vom 16.4.1855 in Zürich zuhanden von J. W. von Deschwanden, unter Ankündigung der Ausstellung einer separaten Wahlurkunde.
Unterzeichnung durch den Direktor des Erziehungswesens, Alfred Escher (1819-1882), und den Sekretär des Erziehungsrates, Friedrich Schweizer (1816-1899)
ReliabilitySPE
Creators: name: Hu, Mengzhen
name: Sui, Jie
name: Yuan-Rui Zheng
name: Liu, Zheng
name: Chuan-Peng, Hu
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Psychology
subject: FOS: Psychology
subject: Social and Behavioral Sciences
subject: Reliability
subject: Multiverse
subject: Self-Prioritization Effect
subject: Self-Perceptual Matching Task

description: The self-prioritization effect (SPE) refers to the effect that performance on cognitive tasks is better when stimuli are related to the self than when they are not. In the last decade, the self -perceptual matching task (SPMT) has emerged as a mainstream paradigm for studying SPE due to its simplicity and elimination of familiarity effects. As a simple button-pressing task, SPMT yields two outcomes: reaction time and accuracy. Other indices can be derived from reaction times and accuracy, including sensitivity d prime under signal-detection theory, the efficiency index through a direct division between reaction times and accuracy, and drift rate (v) and starting point (z) estimated using drift-diffusion models. All these indices have been used to quantify SPE in the literature. However, the reliability of these SPE indices has never been tested. To fill this gap, we will re-analyze existing data from multiple datasets using intraclass correlation coefficient (ICC) and split-half reliability. Our results will provide a benchmark for future studies.
Photometric Properties of Six Local Volume Dwarf Galaxies from Deep Near-Infrared Observations
Creators: name: de Swardt, B.
name: Kraan-Korteweg, R. C.
name: Jerjen, H.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We have obtained deep near-infrared $J$- (1.25 $μ$m), $H$- (1.65$ μ$m) and $K_s$-band (2.15 $μ$m) imaging for a sample of six dwarf galaxies ($M_B\ga-17$ mag) in the Local Volume (LV, $D\la10$ Mpc). The sample consists mainly of early-type dwarf galaxies found in various environments in the LV. Two galaxies (LEDA 166099 and UGCA 200) in the sample are detected in the near-infrared for the first time. The deep near-infrared images allow for a detailed study of the photometric and structural properties of each galaxy. The surface brightness profiles of the galaxies are detected down to the ~$24 mag arcsec^{-2}$ isophote in the $J$- and $H$-bands, and $23 mag arcsec^{-2}$ in the $K_s$-band. The total magnitudes of the galaxies are derived in the three wavelength bands. For the brightest galaxies ($M_B\la-15.5$ mag) in the sample, we find that the Two Micron All Sky Survey (2MASS) underestimates the total magnitudes of these systems by up to $\la0.5$ mag. The radial surface brightness profiles of the galaxies are fitted with an exponential (for those galaxies having a stellar disk) or Sérsic law to derive the structure of the underlying stellar component. In particular, the effective surface brightness ($μ_e$) and effective radius ($r_e$) are determined from the analytic fits to the surface brightness profile. The $J$-$K_s$ colours for the galaxies have been measured to explore the luminosity-metallicity relation for early-type dwarfs. In addition, the $B$-$K_s$ colours of the galaxies are used to assess their evolutionary state relative to other galaxy morphologies. The total stellar masses of the dwarf galaxies are derived from the $H$-band photometric measurements. These will later be compared to the dynamical mass estimates for the galaxies to determine their dark matter content.
description: 14 pages, 8 figures, submitted to MNRAS
City of Dog
Creators: name: Ottewill-Soulsby, Sam
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Original Research Articles
St. Christopher
cynocephali
polis
monster
Ratramnus

description: To be fully human in the Greco-Roman world was to be a member of a city. This is unsurprising as cities were the building blocks of Greek and Roman culture and society. The urban landscape of post-Roman Western Europe looked dramatically different, with smaller, less economically diverse cities which played a smaller role in administration. Despite this, Greco-Roman ideas of humans as city-beings remained influential. This article explores this by investigating early medieval descriptions of cynocephali, which sought to determine whether the dog-headed men were human or not. Accounts of the cynocephali that presented them as human showed them living in urban settlements, whereas in reports of non-human cynocephali there are no cities. In exploring interactions between cynocephali and urban settings through ethnographic portrayals and hagiography, this article traces the lingering importance of the city for concepts of humanity.
Erneuerung der Wahl von Joseph Wolfgang von Deschwanden (1819-1866) zum Mitglied der Aufsichtskommission der Industrieschule Zürich, beschlossen durch den Direktor des Erziehungswesens und durch den Erziehungsrat des Kantons Zürich
Creators: name: Zürich: Kanton: Erziehungsdirektion des Kantons Zürich
Publisher: name: [s.n.]
Year: 1862

description: Auszug des Beschlusses, 26.6.1862 in Zürich, zuhanden von J. W. von Deschwanden.
Unterzeichnet durch den Direktor des Erziehungswesens, Eduard Suter (1820-1891), und den Sekretär des Erziehungsrates, Friedrich Schweizer (1816-1899)
On the Quantized Relativistic Mean Field Theory for Nuclear Matter
Creators: name: Zhang, Qi-Ren
name: Gao, Chun-Yuan
Publisher: name: arXiv
Year: 2010
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We propose a quantization procedure for the nucleon-scalar meson system, in which an arbitrary mean scalar meson field $ϕ$ is introduced. The equivalence of this procedure with the usual ones is proven for any given value of $ϕ$. By use of this procedure, the scalar meson field in the Walecka's RMFT and in Chin's RHA are quantized around the mean field. Its corrections on these theories are considered by perturbation up to the second order. The arbitrariness of $ϕ$ makes us free to fix it at any stage in the calculation. When we fix it in the way of Walecka's RMFT, the quantum corrections are big, and the result does not converge. When we fix it in the way of Chin's RHA, the quantum correction is negligibly small, and the convergence is excellent. It shows that RHA covers the leading part of quantum field theory for nuclear systems and is an excellent zeroth order approximation for further quantum corrections, while the Walecka's RMFT does not. We suggest to fix the parameter $ϕ$ at the end of the whole calculation by minimizing the total energy per-nucleon for the nuclear matter or the total energy for the finite nucleus, to make the quantized relativistic mean field theory (QRMFT) a variational method.
Mietvertrag, ausgestellt von J. Meyer Nägeli, zuhanden von Joseph Wolfgang von Deschwanden (1819-1866)
Creators: name: Meyer Nägeli, J.
Publisher: name: [s.n.]
Year: 1863

description: Handschriftlicher Vertrag betr. Vermietung einer 6-Zimmer-Wohnung, mit dem Zins von 600 Franken jährlich für die Wohnung Nr. 36 im Beckenhof, unterzeichnet von J. Meyer Nägeli im Kreuel
MPEC 2023-J162 : 2023 JT2
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 JT2

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Ausweis, ausgestellt im Zusammenhang mit dem Wohnortswechsel (militärische Abmeldung), zuhanden von Joseph Wolfgang von Deschwanden (1819-1866)
Creators: name: Briner, K., Sektionschef
Publisher: name: [s.n.]
Year: 1863

description: Vordruck, ausgefüllt in Unterstrass, für Professor J. W. von Deschwanden, mit der Bemerkung: "ist wegen seiner Stelle dienstfrei", unterzeichnet von K. Briner, Sektionschef
Ixalus hypomelas Gu.
Creators: name: Müller, F
Publisher: name: Zenodo
Year: 1885
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Amphibia
Anura
Rhacophoridae
Ixalus
Ixalus hypomelas

description: * Ixalus hypomelas Gü. a. sp. aff. ang.
Anamallays v. F. M. [1]
description: Published as part of Müller, F, 1885, Vierter Nachtrag zum Katalogder herpetologischen Sammlung des Basler Museums, pp. 668-717 in Verhandlungen der Naturforschenden Gesellschaft in Basel. 7 (3) on page 671, DOI: 10.5962/bhl.part.2388, http://zenodo.org/record/15183591
A delay differential model of ENSO variability, Part 2: Phase locking, multiple solutions, and dynamics of extrema
Creators: name: Zaliapin, Ilya
name: Ghil, Michael
Publisher: name: arXiv
Year: 2010
Subjects: subject: Atmospheric and Oceanic Physics (physics.ao-ph)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences

description: We consider a highly idealized model for El Nino/Southern Oscillation (ENSO) variability, as introduced in an earlier paper. The model is governed by a delay differential equation for sea surface temperature in the Tropical Pacific, and it combines two key mechanisms that participate in ENSO dynamics: delayed negative feedback and seasonal forcing. We perform a theoretical and numerical study of the model in the three-dimensional space of its physically relevant parameters: propagation period of oceanic waves across the Tropical Pacific, atmosphere-ocean coupling, and strength of seasonal forcing. Phase locking of model solutions to the periodic forcing is prevalent: the local maxima and minima of the solutions tend to occur at the same position within the seasonal cycle. Such phase locking is a key feature of the observed El Nino (warm) and La Nina (cold) events. The phasing of the extrema within the seasonal cycle depends sensitively on model parameters when forcing is weak. We also study co-existence of multiple solutions for fixed model parameters and describe the basins of attraction of the stable solutions in a one-dimensional space of constant initial model histories.
description: Nonlin. Proc. Geophys., 2010, accepted
Entwurf für ein Zeugnis für Hr. Roduner in Folge eines Examens 1862 in darstellender Geometrie, verfasst von Joseph Wolfgang von Deschwanden (1819-1866)
Creators: name: Deschwanden, Joseph Wolfgang von
Publisher: name: [s.n.]
Year: 1862

description: Handschriftlicher Entwurf, verfasst vermutlich in Zürich
Joseph Wolfgang von Deschwanden (1819-18669 an J. W. Wagner, Abschrift
Creators: name: Deschwanden, Joseph Wolfgang von
Publisher: name: [s.n.]
Year: 1862

description: Eigenhändige Kopie eines Briefes an J. W. Wagner in Lublin, erstellt im Zusammenhang mit der Ausbildung des Sohnes von Wagner
Investigation of the uptake of volatile phenols in smoke exposed Vitis vinifera vines
Creators: name: Zigg, Ieva
Publisher: name: University of British Columbia
Year: 2025

description: Significant losses are incurred by the wine industry when wildfire smoke taints the grapes, causing the fermented wine to taste disagreeably burnt and ashy. These unpleasant aromas are thought to be triggered by the presence – as low as parts per billion in concentration – of volatile phenols (VPs), a class of compounds found in smoke. Current research is focused on developing ways to remove VPs from wine or blocking their entry into grapes, but due to their low concentrations and the complex grape matrix even detecting them is challenging and expensive. Moreover, VP uptake, transport, and metabolism in the grapevine are poorly understood. This thesis compared two published methods for determination of smoke volatiles in grapes. Improvements to the extraction procedure were then introduced by selectively targeting specific steps in the literature methods, combining the most efficient ones and optimizing the complex, time-consuming parts. The final, optimized method is the first (published) to date that quantitates VPs within the entire grape (vs. only juice), more accurately reflecting the red wine-making process. Improved accuracy of VP detection will result in risk reduction to winemakers. The new VP procedure was used to test if smoke can enter the berries through smoke exposed leaves or through the roots irrigated with smoke-contaminated water. Watering with tainted water had no effect on the grapes or leaves – a positive finding, indicating that irrigation with lake or rain water during wildfire season should not ruin the crops. Further, this thesis developed a smoke taint research model using greenhouse-grown, potted Shiraz grapevines and a kitchen food smoker for treatment application. Filling plastic bags tied around parts of the vine with smoke from burning local fuel sources allowed for a convenient, targeted investigation of VP uptake and transport. No volatile phenols were detected moving out of tainted grapes, but some evidence was found that they may be transported into the berries from smoke exposed leaves. Thus, in addition to providing the community a new, accurate VP method, this thesis adds to our knowledge of VP uptake and storage within smoke-exposed grapevines, providing a foundation on which to build protection efforts.
Direktion des Militärwesens, A. Voegeli, an Joseph Wolfgang von Deschwanden (1819-1866)
Creators: name: Zürich: Kanton: Militärdirektion
Publisher: name: [s.n.]
Year: 1863

description: Brief aus Zürich.
Aufforderung zur Zahlung des Militärpflichtersatzes für die Jahre 1856-1861, unterzeichnet von Arnold Voegeli, Major im eidgen. Generalstab, Direktion des Militärwesens des Kantons Zürich, Sekretär