cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Synthesis of novel thiazoles bearing lupeol derivatives as potent anticancer and anti-inflammatory agents
Creators: name: Narendar, Kummari
name: Rao, B. Sambasiva
name: Tirunavalli, Satyakrishna
name: Jadav, Surender Singh
name: Andugulapati, Sai Balaji
name: Ramalingam, Vaikundamoorthy
name: Babu, K. Suresh
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Lupeol is one of the most important metabolite in the class of terpenoids and possess excellent anticancer, anti-inflammatory, anti-diabetic activities etc. In the present study, the different thiazoles and oxazoles bearing lupeol derivatives were prepared to enhance their biological activity. Initially, the in vitro cytotoxic activity results showed that the synthesized lupeol derivatives (9a–9j and 10a–10e) showed significant activity against various cancer cells and the compounds 9h and 10b exhibited excellent activity against CAL27 cells. Further, these compounds 9h and 10b arrest the cell cycle at S phase and induce the late apoptosis in CAL27 cells by downregulating the BcL2 and vimentin expression and upregulating the Bax gene expression. Moreover, the lupeol derivatives showed dose-dependent anti-inflammatory activity by inhibiting the secretion of IL-6 cytokines in LPS-induced Raw 264.7 cells. Together, these results clearly indicated that the thiazoles and oxazoles bearing lupeol derivatives can used as chemotherapeutic drugs against cancer and inflammatory diseases.
Analysis of phytochemical components of Tibetan medicine Pedicularis flava and Pedicularis muscicola by GC-MS and UHPLC-TOF-MS
Creators: name: Yu, Wentao
name: Luo, Man
name: Wu, Huan
name: Yu, Yayun
name: Li, Junmao
name: He, Minzhen
name: Feng, Yunlin
name: Yang, Shilin
name: Zhang, Wugang
name: Yao, Min
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Space Science
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Traditional medicine, ‘LuRu’, is a commonly used Tibetan medicine for clearing away heat and detoxifying. Dried products of Pedicularis flava and Pedicularis muscicola are often used as ‘LuRu’ in the market. This study aims to compare the chemical constituents of P. flava and P. muscicola using GC-MS and UPLC-TOF-MS, and confirm which plant species is more suitable to be used as ‘LuRu’. A total of 46 and 68 compounds were identified from the volatile and non-volatile components, respectively. Out of these, 17 and 37 volatile and non-volatile components, respectively, had pharmacological activities. P. flava showed a higher content of the same active components than P. muscicola. Good biological activities are only observed in the unique components in P. flava, and not in P. muscicola. The two herbs should not be mixed in clinical medication. Our study shows that P. flava is better suited as a high-quality herb for the Tibetan medicine, ‘LuRu’. Volatile components of Tibetan Pedicularis flava and Pedicularis muscicola were analysed for the first timewiooi.Non-volatile components of Tibetan Pedicularis flava and Pedicularis muscicola were analysed for the first time.Differences in chemical composition and content between Pedicularis flava and Pedicularis muscicola were studied. Volatile components of Tibetan Pedicularis flava and Pedicularis muscicola were analysed for the first timewiooi. Non-volatile components of Tibetan Pedicularis flava and Pedicularis muscicola were analysed for the first time. Differences in chemical composition and content between Pedicularis flava and Pedicularis muscicola were studied.
Taxotrophises A and B, two new polyphenols from the stems of Taxotrophis ilicifolius
Creators: name: Van Do, Truong Nhat
name: Nguyen, Hai Xuan
name: Le, Tho Huu
name: Dang, Phu Hoang
name: Nguyen, Nhan Trung
name: Nguyen, Mai Thanh Thi
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: From the EtOAc extract of the wood of the stems of Taxotrophis ilicifolius (Moraceae), two new secondary metabolites, named taxotrophises A (1) and B (2), were isolated, together with five known compounds (3–7). Their chemical structures have been elucidated by extensive NMR spectroscopic analysis. All isolated compounds have been evaluated for α-glucosidase inhibitory activity. In the present work, compounds 1 and 4 showed the strongest α-glucosidase inhibitory activity with IC50 values of 6.5 and 1.5 μM, respectively, and stronger than that of a positive control, acarbose (IC50; 214.5 μM).
Tomography of the environment of the COSMOS/AzTEC-3 submillimeter galaxy at z=5.3 revealed by Lyalpha and MUSE observations
Creators: name: Guaita, L.
name: Aravena, M.
name: Gurung-Lopez, S.
name: Cantalupo, S.
name: Marino, R.
name: Riechers, D.
name: da Cunha, E.
name: Wagg, J.
name: Algera, H. S. B.
name: Dannerbauer, H.
name: Cox, P.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We study the members of the protocluster around AzTEC3 submillimeter galaxy at z=5.3. We analyzed the data from the MUSE instrument in an area of 1.4x1.4 arcmin^2 around AzTEC3 and derived information on the Lya line in emission. We compared the Lya profile of various regions of the environment with the zELDA radiative transfer model, revealing the neutral gas distribution and kinematics. We identified 10 Lya emitting sources, including 2 regions with extended emission: one embedding AzTEC3 and LBG3, a star-forming galaxy located 12 kpc north of the SMG and another toward LBG-1, a star-forming galaxy located 90 kpc to the southeast. The sources appear distributed in an elongated configuration of about 70'' in extent. The number of sources confirms the overdensity around AzTEC3. For the AzTEC3+LBG3 system, the Lya emission appears redshifted and more spatially extended than the [CII] line emission. Similarly, the Lya line spectrum is broader in velocity than [CII] for LBG1. In the former spectrum, the Lya emission is elongated to the north of LBG3 and to the south of AzTEC3, where a faint Lya emitting galaxy is also located. The elongated structures could resemble tidal features due to the interaction of the two galaxies with AzTEC3. Also, we find a bridge of gas, revealed by the Lya emission between AzTEC3 and LBG3. The Lya emission toward LBG1 embeds its three components. The HI kinematics support the idea of a merger of the three components. Given the availability of CO and [CII] observations from previous campaigns, and our Lya information, we find evidence of starburst-driven phenomena and interactions around AzTEC-3. The stellar mass of the galaxies of the overdensity and the Lya luminosity of the HI nebula associated with AzTEC-3 imply a dark matter halo of 10^12 Msun at z=5.3 that could evolve into a cluster of 2x10^14 Msun at z=0.
description: Submitted to A&A, Accepted on Feb 4th, 2022
Discrete Anomaly Matching for the Pouliot Type Dualities
Creators: name: Kawano, Teruhiko
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We compute the 't Hooft anomalies of discrete symmetries in the Pouliot type dual theories and check their anomaly matching conditions. The Pouliot type dual theories we will consider in this paper are two dual pairs; the dual pair of ${\cal N}=1$ supersymmetric theories of a $Spin(7)$ gauge theory with spinors and a $SU(N_f-4)$ gauge theory with a symmetric tensor, fundamentals and singlets, and the other dual pair of ${\cal N}=1$ supersymmetric theories of a $Spin(10)$ gauge theory with a spinor and vectors and a $SU(N_f-5)$ gauge theory with a symmetric tensor, fundamentals and singlets. We will show that the both pairs satisfy the discrete anomaly matching conditions.
description: 32 pages, typos corrected
Integracide derivatives produced by endophyte Fusarium armeniacum M-3 isolated from Digitaria ciliaris
Creators: name: Sato, Shiho
name: Sofian, Ferry Ferdiansyah
name: Paulin, Dradre Atakuru
name: Kobayashi, Sho
name: Koseki, Takuya
name: Shiono, Yoshihito
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Two new integracides, dedimethyl integracide B (1) and integracide K (2), were isolated from rice cultures of Fusarium armeniacum M-3, an endophyte isolated from Digitaria ciliaris, together with the known terpenoids, integracide B (3) and 2-deoxy-integracide B (4). Assignment of the signals in the 1H and 13C NMR spectra of 1 and 2 was achieved using DEPT, HMQC, HMBC, and NOESY spectra. Compound 2 exhibited moderate cytotoxicity against HeLa cells.
Factors affecting assessment and back-analysis by piezometer monitoring
Creators: name: Arulrajah, Arul
name: Nikraz, H.
name: Bo, M. W.
Publisher: name: Swinburne
Year: 2024

description: The use of prefabricated vertical drains with preloading option is the most widely-used ground improvement method for the improvement of marine clays in land reclamation projects. The assessment of the degree of consolidation of the marine clay is of paramount importance prior to the removal of preload in such ground improvement projects. This analysis can be carried out by means of piezometer monitoring. Piezometer monitoring data can be analysed to obtain the degree of consolidation of the improved marine clay. Back-analysis of the piezometer data will also enable the coefficient of consolidation due to horizontal flow to be estimated. Factors that affect the analysis of piezometers include period of assessment, hydrogeologic boundary condition, settlement of piezometer tip and reduction of initial imposed load due to submergence effect. The aim of this paper is to highlight the significance and impact of the various factors that affect assessment by the piezometer monitoring method.
Isolation and identification of anti-inflammatory and analgesic polysaccharides from Coix seed (Coix lacryma-jobi L.var. Ma-yuen (Roman.) Stapf)
Creators: name: Sui, Yingling
name: Xu, Deping
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Coix seed is a nutrient-rich food and traditional Chinese medicine with anti-inflammatory and analgesic properties. Polysaccharides from Coix seed have been rarely investigated for structure and activities. In this study, the analgesic and anti-inflammatory effects were investigated in vivo and in vitro. The results showed that Coix seed had a significant influence on reducing the number of writhing, increasing the pain threshold and alleviating the swelling degree caused by acute inflammation. Column chromatography was used to obtain two active compounds of Coix seed. Compound 1 was (1→6)-α-glucan with a molecular weight of 6.81 × 105 Da. The chemical connection of compound 2 was as follows: α-Frup (2→ [1)-α-Glcp (6]5→1)-α-Glcp (4→1)-α-Glcp, which was isolated in Coix seed for the first time. LPS-induced inflammation in RAW264.7 cells was well inhibited by compounds. These findings offered a preliminary investigation into the analgesic and anti-inflammatory properties of Coix seed, which may be helpful for application.
Two new benzophenones from the moss Pogonatum spinulosum
Creators: name: Duan, Wen-Bin
name: Peng, An-tang
name: Yuan, Shi-Nong
name: Wang, Shao-Nan
name: Li, Bo-Wen
name: Duan, Xu-Hong
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biophysics
Biochemistry
Space Science
Medicine
Cell Biology
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Two new benzophenone derivatives (1 and 2), named Pogonatone C and pogonatone D, were isolated from the moss Pogonatum spinulosum. Their structures were elucidated by spectroscopic data analyses. The cytotoxicity of compounds for HepG2, HCT-116, A-549 and PANC-1 cells line was also evaluated by using the MTT method. Pogonatone C (1) displays high cytotoxicity on PANC-1 cell with IC50 value of 9.2 μM.
Two new aryltetralin-type lignans from Camellia oleifera husk
Creators: name: Cheng, Huai-yu
name: Xu, Tian-qi
name: Hu, Ya-lin
name: Shu, Qing
name: Xu, Wei
name: Fan, Chun-lin
name: Zhou, Guang-xiong
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Plant Biology
subject: FOS: Biological sciences

description: Two new aryltetralin-type lignans (1-2) were isolated from the dichloromethane fraction of 95% ethanol extract of Camellia oleifera fruit husk. Their structures were elucidated on the basis of spectroscopic analysis, and the absolute configurations of compounds 1-2 were determined by the comparison of measured ECD curves with the quantum chemical calculated ones. The new compounds were tested for their antioxidant activities and cytotoxicity against three human cancer cell lines (Huh-7, H460 and MCF-7). While compounds 1 and 2 only showed slight DPPH radical scavenging activities with the IC50 values of 38.68 ± 5.02 and 56.62 ± 1.49 μM, respectively.
Stellar population gradients at cosmic noon as a constraint to the evolution of passive galaxies
Creators: name: Ditrani, F. R.
name: Andreon, S.
name: Longhetti, M.
name: Newman, A.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Context: The radial variations of the stellar populations properties within passive galaxies at high redshift contain information about their assembly mechanisms, based on which galaxy formation and evolution scenarios may be distinguished. Aims: The aim of this work is to give constraints on massive galaxy formation scenarios through one of the first analyses of age and metallicity gradients of the stellar populations in a sample of passive galaxies at $z > 1.6$ based on spectroscopic data from the Hubble Space Telescope. Methods: We combined G$141$ deep slitless spectroscopic data and F$160$W photometric data of the spectroscopically passive galaxies at $1.6< z < 2.4$ with $H_{160} < 22.0$ in the field of view of the cluster JKCS $041$. We extracted spectra from different zones of the galaxies, and we analysed them by fitting them with a library of synthetic templates of stellar population models to obtain estimates of the age and metallicity gradients. Results: We obtained reliable measurements of age and metallicity parameters in different spatial zones of $\text{four}$ galaxies. We performed spatially resolved measurements in individual high-redshift galaxies without the need of peculiar situations (i.e. gravitational lensing) for the first time. All four galaxies exhibit negative metallicity gradients. Their amplitude, similar to that measured in galaxies in the local Universe, suggests that the stellar populations of passive galaxies from $z \sim 2$ to $z = 0$ are not redistributed. Conclusions: Although the sample we analysed is small, the results we obtained suggest that the main mechanism that determines the spatial distribution of the stellar population properties within passive galaxies is constrained in the first $3$ Gyr of the Universe. This is consistent with the revised monolithic scenario.
description: 19 pages, 25 figures. Submitted 25/10/2021, Accepted 26/01/2022
A "no-drift" runaway pile-up of pebbles in protoplanetary disks II. Characteristics of the resulting planetesimal belt
Creators: name: Hyodo, Ryuki
name: Ida, Shigeru
name: Guillot, Tristan
Publisher: name: arXiv
Year: 2022
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Forming planetesimals from pebbles is a major challenge in our current understanding of planet formation. In a protoplanetary disk, pebbles drift inward near the disk midplane via gas drag and they may enter a dead zone. In this context, we identified that the backreaction of the drag of pebbles onto the gas could lead to a runaway pile-up of pebbles, the so-called no-drift mechanism. We improve upon the previous study of the no-drift mechanism by investigating the nature and characteristics of the resultant planetesimal belt. We performed 1D diffusion-advection simulations of drifting pebbles in the outer region of a dead zone by including the backreaction to the radial drift of pebbles and including planetesimal formation via the streaming instability. We considered the parameters that regulate gas accretion and vertical stirring of pebbles in the disk midplane. In this study, the pebble-to-gas mass flux ($F_{\rm p/g}$) was fixed as a parameter. We find that planetesimals initially form within a narrow ring whose width expands as accumulating pebbles radially diffuse over time. The system finally reaches a steady-state where the width of the planetesimal belt no longer changes. A non-negligible total mass of planetesimals (more than one Earth mass) is formed for a disk having $F_{\rm p/g} \gtrsim 0.1$ for more than $\sim 10-100$ kyr with nominal parameters: a gas mass flux of $\gtrsim10^{-8} {\rm M}_\oplus$/yr, $τ_{\rm s} \simeq 0.01-0.1$, $α_{\rm mid} \lesssim 10^{-4}$, and $α_{\rm acc} \simeq 10^{-3}-10^{-2}$ at $r \lesssim 10$ au, where $r$, $τ_{\rm s}$, $α_{\rm mid}$, and $α_{\rm acc}$ are the heliocentric distance, the Stokes number, and the parameters in a dead zone controlling the efficiencies of vertical turbulent diffusion of pebbles (i.e., scale height of pebbles) and gas accretion of the $α$-disk (i.e., gas surface density), respectively.
description: 13 pages, 7 Figures, accepted for publication in Astronomy & Astrophysics (A&A)
A novel flavonoid and other constituents from Rubus rosifolius S.Vidal (Rosaceae)
Creators: name: Yin, Yihao
name: Huang, Yunqi
name: Yang, Wencong
name: Yuan, Jie
name: Xie, Minli
name: Miao, Yongfeng
name: Yu, Jinxiu
name: Wang, Juncong
name: Zhang, Xiuping
name: Wang, Bo
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biochemistry
Pharmacology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Science Policy

description: Various reports revealed that chemical constituents from many species of Rubus exhibit diverse biological activities. In this study, a novel flavonoid with a 2-(phenanthren-9-yl)-4H-chromen-4-one structure (1), a 5-phenylthiophene-2-carbaldehyde derivative (5) first isolated from a natural source, together with five known compounds including three polyketides (2–4) and two sesquiterpenoids (6–7) were isolated from a traditional Chinese medicine Rubus rosifolius S.Vidal (Rosaceae). The structures of new compounds were elucidated by detailed spectroscopic analysis including NMR and X-ray single-crystal diffraction. The bioassays results indicated that, compound 1 displayed significant cytotoxicity against human colon cancer cell line HCT116 with IC50 value of 8.6 ± 1.9 μM, and compound 5 exhibited moderate cytotoxicity against human breast cancer cell line MDA-MB-435 with IC50 value of 24.1 ± 0.8 μM.
Calcium germanate nanowires by vanadium doping with improved photocatalytic activity
Creators: name: L.Z. Pei
name: S. Wang
name: N. Lin
name: H.D. Lin
name: H.Y. Yu
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Physiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Physics
subject: Biophysics

description: Vanadium-doped calcium germanate nanowires were prepared by a simple hydrothermal method. The samples were analysed by X-ray diffraction (XRD), scanning electron microscopy (SEM) and solid UV–Vis diffuse reflectance spectrum. The photocatalytic activity of the vanadium-doped calcium germanate nanowires was investigated by the degradation of methylene blue (MB) under solar light irradiation. The results show that the vanadium-doped calcium germanate nanowires are composed of rhombohedral Ca3GeO5 and orthorhombic CaV3O7 phases. The nanowires have the diameter and length of 50–200 nm and several dozens of micrometres, respectively. The band gap of the vanadium-doped calcium germanate nanowires strongly depends on the vanadium doping mass percentage. The absorption spectrum can be broadened to visible light region. The photocatalytic activity of the vanadium-doped calcium germanate nanowires is remarkably improved. Vanadium-doped calcium germanate nanowires with the vanadium doping mass percentage of 10% have the highest photocatalytic activity for MB degradation under solar light irradiation.
On the traversability of wormhole solutions in asymptotically safe gravity
Creators: name: Nilton, M.
name: Furtado, J.
name: Alencar, G.
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this paper we study the traversability of a wormhole in the context of Asymptotically Safe Gravity (ASG) for two different cases, namely, the spherical case and the pseudospherical case. We carried out an analysis in the throat of the wormhole with an specific choice of the cutoff function $f=ξR$. Recently, this study has been performed in Ref \cite{Moti:2020whf}, however the authors consider only a classical source with constant state parameter $ω$. Here we have generalized their study in two ways: a) with a classical state parameter which is dependent of the position $ω(r)$ and b) with an ASG improvement of the source. We have showed that it is possible to have traversability with exotic and non-exotic matter, but the kind of matter is highly dependent on the wormhole's parameters.
description: 12 pages, 10 figures. Two figures included. Matches version accepted in Phys. Rev. D
Atmospheric processes affecting methane on Mars
Creators: name: Grenfell, John Lee
name: Wunderlich, Fabian
name: Sinnhuber, Miriam
name: Herbst, Konstantin
name: Lehmann, Ralph
name: Scheucher, Markus
name: Gebauer, Stefanie
name: Arnold, Gabrielle
name: Rauer, Heike
Publisher: name: arXiv
Year: 2022
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: It is currently uncertain as to whether methane exists on Mars. Data from the Curiosity Rover suggests a background methane concentration of a few tenths parts per billion whereas data from the Trace Gas Orbiter suggest an upper limit of twenty parts per trillion. If methane exists on Mars then we do not understand fully the physical and chemical processes affecting its lifetime. Atmospheric models suggest an over-estimate in the lifetime by a factor of around six hundred compared with earlier observations. In the present work we assume the Curiosity Rover background methane value and estimate the uncertainty in atmospheric chemistry and mixing processes in our atmospheric column model 1D TERRA. Results suggest that these processes can only explain a factor of ~sixteen lowering in the methane lifetime. This implies that if methane is present then additional, currently unknown processes are required to explain the observed lifetime.
Characterization of thymol derivatives from Eupatorium fortunei Turcz. aerial parts
Creators: name: Nguyen-Ngoc, Hieu
name: Trang, Bui Thi Thu
name: Thu, Do Thi Hoai
name: Nguyen, Huu Tung
name: Hoang, Vu Dinh
name: De Tran, Quang
name: Nguyen, Tuan Ngoc
name: Quang, Dang Ngoc
name: Pham, Giang Nam
name: Le Dang, Quang
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Virology

description: From the aerial parts of Eupatorium fortunei, four thymol derivatives (1-4) were isolated and structurally elucidated by NMR and mass spectroscopic methods. Of which, a new dimeric thymol derivative (1) was characterized and its absolute configuration was established by electronic circular dichroism quantum method. In addition, the 1D and 2D NMR as well as HR-ESI mass spectral data of 2 were provided for the first time. Compounds 2-4 were evaluated for their inhibitory activity against α-glucosidase and acetylcholinesterase enzymes. All tested compounds showed weak inhibition at the concentration range of 1–256 μg/mL in both enzymatic assays.
Analyzing the Hubble tension through hidden sector dynamics in the early universe
Creators: name: Aboubrahim, Amin
name: Klasen, Michael
name: Nath, Pran
Publisher: name: arXiv
Year: 2022
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The recent analysis from the SH0ES Collaboration has confirmed the existence of a Hubble tension between measurements at high redshift ($z> 1000$) and at low redshift ($z<1$) at the $5σ$ level with the low redshift measurement giving a higher value. In this work we propose a particle physics model that can help alleviate the Hubble tension via an out-of-equilibrium hidden sector coupled to the visible sector. The particles that populate the dark sector consist of a dark fermion, which acts as dark matter, a dark photon, a massive scalar and a massless pseudo-scalar. Assuming no initial population of particles in the dark sector, feeble couplings between the visible and the hidden sectors via kinetic mixing populate the dark sector even though the number densities of hidden sector particles never reach their equilibrium distribution and the two sectors remain at different temperatures. A cosmologically consistent analysis is presented where a correlated evolution of the visible and the hidden sectors with coupled Boltzmann equations involving two temperatures, one for the visible sector and the other for the hidden sector, is carried out. The relic density of the dark matter constituted of dark fermions is computed in this two-temperature formalism. As a consequence, BBN predictions are upheld with a minimal contribution to $ΔN_{\rm eff}$. However, the out-of-equilibrium decay of the massive scalar to the massless pseudo-scalar close to the recombination time causes an increase in $ΔN_{\rm eff}$ that can help weaken the Hubble tension.
description: 28 pages, 7 figures, 1 table (Accepted for publication in JCAP)
New alkaloids from Polygonatum zanlanscianense Pamp
Creators: name: Zhang, Xue-Ke
name: Han, Zhu-Zhen
name: Yang, Li
name: Zhang, Peng-Fei
name: Zhang, Hong
name: Liu, Shou-Jin
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Sixteen alkaloid compounds were isolated from the dried rhizomes of P. zanlanscianense, including a pair of new enantiomers (R/S)-7'-ethoxy-trans-p-couma-royltyramine (1a/1b) and 14 known compounds (2-14) isolated from this plant for the first time. The structures of new compounds were identified by IR, NMR and MS spectroscopic analysis, and their absolute configurations were determined by comparison of the experimental and calculated ECD data.
Breaking Orion's Veil bubble with fossil outflows
Creators: name: Kavak, U
name: Goicoechea, J. R.
name: Pabst, C. H. M.
name: Bally, J.
name: van der Tak, F. F. S.
name: Tielens, A. G. G. M.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The role of feedback in the self-regulation of star formation is a fundamental question in astrophysics. The Orion Nebula is the nearest site of ongoing and recent massive star formation. It is a unique laboratory for the study of stellar feedback. Recent SOFIA [CII] 158 $μ$m observations revealed an expanding bubble, the Veil shell, being powered by stellar winds and ionization feedback. We have identified a protrusion-like substructure in the Northwest portion of the Orion Veil Shell that may indicate additional feedback mechanisms that are highly directional. Our goal is to investigate the origin of the protrusion by quantifying its possible driving mechanisms. We use the [CII] 158 $μ$m map of the Orion Nebula obtained with the upGREAT instrument onboard SOFIA. The spectral and spatial resolution of the observations are 0.3 km/s and 16 arcsec, respectively. We consider three possible origins for this protrusion: Fossil outflow cavities created by jets/outflows during the protostellar accretion phase, pre-existing clumpiness in the OMC-1 core, and the stellar wind during the main sequence phase. Based on the energetics and the morphology, we conclude that the northwestern part of the pre-existing cloud was locally perturbed by outflows ejected from massive protostars in the Trapezium cluster. This suggests that the protrusion of the Veil is the result of mechanical rather than radiative feedback. Furthermore, we argue that the location of the protrusion is a suitable place to break the Orion Veil owing to the photo-ablation from the walls of the protrusion. We conclude that the outflows of massive protostars can influence the morphology of the future \hii\,region and even cause breakages in the ionization front. Specifically, the interaction of stellar winds of main-sequence stars with the molecular core pre-processed by the protostellar jet is important.
description: Accepted by A&A on Feb 9, 2022 (20 pages, 19 figures)
On the possible existence of a soft dipole mode in 8He
Creators: name: Piekarewicz, J.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Nuclear Theory (nucl-th)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: With an extreme neutron-to-proton ratio of N/Z=3, 8He provides an ideal laboratory for the study of a variety of exotic phenomena, such as the emergence of a soft dipole mode that is dominated by transitions into the continuum. In this contribution, a covariant density functional theory (DFT) framework is used to compute ground-state properties and the dipole response of 8He. Although 8He is admittedly too light for DFT to be applicable, the great merit of the approach is that the spurious contamination associated with the center-of-mass motion is guaranteed to decouple from the physical response. Given that a strong mixing between the isoscalar and isovector dipole modes is expected for a system with such a large neutron-proton asymmetry as 8He, the narrow structures that emerged at low energies in the isovector dipole response are attributed to the shift of the spurious strength to zero (or near zero) excitation energy. Thus, the theoretical framework implemented here disfavors the emergence of a soft dipole mode in 8He.
description: 8 pages, 7 figures, and two tables. Submitted to the Physical Review C
Impact of seasonal variation on four labdane-type diterpenoids in Coleus forskholii Briq
Creators: name: Chaudhary, Mridul Kant
name: Misra, Ankita
name: Tripathi, Deepali
name: Srivastava, Prabhat Kumar
name: Srivastava, Sharad
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: The present study has been planned to evaluate the impact of seasonal variation in labdane-type diterpenoids namely isoforskolin, forskolin, 1,9-dideoxyforskolin and 1-deoxyforskolin in Coleus forskholii (roots). The plant samples were harvested in different seasons from our experimental field located at CSIR-NBRI garden, Lucknow (India) and metabolite contents were estimated through validated high performance thin layer chromatography (HPTLC) method. The HPTLC plate was developed in tertiary mobile phase of toluene-ethyl acetate-methanol (8.5-1-0.05 v/v) for separation of all the four metabolites. The metabolite content viz. isoforskolin, forskolin, 1,9-dideoxyforskolin and 1-deoxyforskolin varies from 0.0247% to 0.198%, 0.238 to 0.730%, 0.056 to 0.161% and 0.0401 to 0.332% on dry weight basis respectively. The maximum content of metabolites was recorded in winter season and was found optimum for harvesting of C. forskholii roots. Optimization of harvesting season for this industrially valuable medicinal plant will lead to sustainable sources of good quality raw material to herbal drug industry.
Diorygmones A-B, two new guaiane-sesquiterpenes from the cultured lichen mycobiont of Diorygma sp.
Creators: name: Nguyen, Huu-Hung
name: Aree, Thammarat
name: Nguyen, Huy Truong
name: Tran, Thi-Minh-Dinh
name: Nguyen, Thi-Phuong
name: Vo, Thi-Phi Giao
name: Nguyen, Ngoc-Hong
name: Duong, Thuc-Huy
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Diorygma sp. is a native crustose-lichen in Vietnam. A mycobiont of this lichen was isolated, then cultivated. The present study described the isolation and structural elucidation of two new guaiane-type sesquiterpenes, namely diorygmones A-B. Their absolute chemical structures were elucidated by extensive 1D and 2D NMR analysis, high-resolution mass spectroscopy, electronic circular dichroism (ECD), and comparisons with the literatures. Compounds 1 and 2 were evaluated for cytotoxic activity against HepG2 cell line.
Identification and determination of flavonoids, carotenoids and chlorophyll concentration in Cynodon dactylon (L.) by HPLC analysis
Creators: name: Saradha Devi Muthukrishnan
name: Ashokkumar Kaliyaperumal
name: Annapoorani Subramaniyan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Science Policy
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Pharmacology
subject: Molecular Biology
subject: Biochemistry

description: Cynodon dactylon (L.) is a potent medicinal plant in the traditional and current Indian medicinal systems. The objective of this research was to find out the levels of flavonoids, carotenoids and chlorophyll b in C. dactylon leaves by high-performance liquid chromatography (HPLC) equipped with a diode array detector. HPLC analysis revealed that total carotenoid and total flavonoid concentration were 62 mg/100 g and 249.1 μg/g, respectively. The mean chlorophyll b was 85.1 mg/100 g in C. dactylon. Among the flavonoids, quercetin (164.7 μg/g) was the major flavonoid followed by kaempferol (48.2 μg/g), rutin (18.4 μg/g), catechin (12.1 μg/g) and myricetin (5.7 μg/g). Of the carotenoids, β-carotene (35.2 mg/100 g) was predominant followed by lutein (17.0 mg/100 g), violaxanthin (5.8 mg/100 g) and zeaxanthin (4.2 mg/100 g). Chlorophyll b concentration was 85.1 mg/100 g in C. dactylon. The results of this investigation should be useful information for further pharmacological studies.
Synchronization Collapse Cosmology: A Recursive Emergence Model of Spacetime and Structure
Creators: name: Delaude, Julien
Publisher: name: Zenodo
Year: 2025
Subjects: Cosmology
Synchronization Collapse
Entropy Bifurcation
Spacetime Emergence
Recursive Systems

description: Initial abstract release of Synchronization Collapse Cosmology (SCC), a recursive entropy-order framework modeling spacetime, structure, and expansion as synchronization scars. This document outlines the theoretical substrate for differential expansion and cosmic web formation, forming part of PÆNDORÆ’S BOX.

KOSMÆOS_abstract.pdf — Recursive cosmological summaryLICENSE — PÆNDORÆ R&D RestrictedTIMESTAMP.SHA512 — Authorship proof and integrity record

This work is released under symbolic license for reference and alignment purposes. For licensing or theoretical integration inquiries, contact Julien Delaude.
description: A recursion-based cosmology of collapse-induced spacetime and emergent structure.
Impurity effects on binding energy, diamagnetic susceptibility and photoionization cross-section of chalcopyrite AgInSe2 Nanotadpole
Creators: name: Mantashian, Grigor A.
name: Hayrapetyan, David B.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Recently the interest in chalcopyrite semiconductor nanostructures has increased because of their non-toxicity and their wide direct bandgap. Likewise, structures with non-trivial geometry are particularly interesting because of their electronic, optical, and magnetic properties. In the current article, the finite element method was used in conjunction with the effective mass approximation to theoretically investigate the properties of a chalcopyrite AgInSe2 nanotadpole in the presence of an off-center impurity. The morphology of the nanotadpole gives it excellent hydrodynamic properties and is ideal for a wide range of applications. The probability densities for various impurity positions and energy levels were obtained. The results suggested a strong dependence of the behavior of the electron on the impurity positions and the orientation of the wave function. The binding energy's dependence on the nanotadpole's size and the impurity position was obtained. The dependence of the diamagnetic susceptibility on the impurity position was calculated. An extensive investigation of the photoionization cross-section and the oscillatory strength was carried out for the ground and the first two excited states as the initial states and the first twenty excited states as the final states.
A new phenyl 6,7-dihydroxygeranyl ether derivative from a marine-derived fungus strain of Penicillium arabicum ZH3-9
Creators: name: Yang, Jinpeng
name: Zhang, Xinwan
name: Xu, Wei
name: Xu, Xiuli
name: Song, Fuhang
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: A new phenyl 6,7-dihydroxygeranyl ether derivative, named (Z)-4-((6,7-dihydroxy-3,7-dimethyloct-2-en-1-yl)oxy)benzoic acid (1), and 8 known compounds (2–9) were characterized from a marine-derived fungus strain of Penicillium arabicum ZH3-9 isolated from a mud sample collected from the coast of Zhuhai, Guangdong Province, China. The structure of 1 was elucidated by HRESIMS, 1 D and 2 D NMR. All compounds were evaluated antimicrobial activities against Candida albicans, Staphylococcus aureus, and Escherichia coli. Compounds 4–6 displayed antibacterial activity against S. aureus with minimum inhibitory concentrations of 50, 12.5, and 50 μg/mL.
Magic Realism as a Narrative Strategy in Elechi Amadi-s Trilogy.pdf
Creators: name: Kalu, Kalu  Obasi
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 470501
subject: African literature

description: The African society is structured in a way to maintain specific functions by different elements. The supernatural remains peaceful, the peace of which transcends human society. The viciousness and evil schemes of mankind to circumvent the stipulation and position of the gods bring about social discomfort and internecine wars. But mutual respect for every element of society within the same social environment brings about lasting peace and harmony. Amadi's position is that African Gods are as powerful and as vengeful as the Christian God. Their powers pervade every sphere of human existence, and they should be accorded the recognition they deserve.maintains
The Gaia-ESO Survey: Age-chemical-clock relations spatially resolved in the Galactic disc
Creators: name: Vázquez, C. Viscasillas
name: Magrini, L.
name: Casali, G.
name: Tautvaišienė, G.
name: Spina, L.
name: Van der Swaelmen, M.
name: Randich, S.
name: Bensby, T.
name: Bragaglia, A.
name: Friel, E.
name: Feltzing, S.
name: Sacco, G. G.
name: Turchi, A.
name: Jiménez-Esteban, F.
name: D'Orazi, V.
name: Delgado-Mena, E.
name: Mikolaitis, Š.
name: Drazdauskas, A.
name: Minkevičiūtė, R.
name: Stonkutė, E.
name: Bagdonas, V.
name: Montes, D.
name: Guiglion, G.
name: Baratella, M.
name: Tabernero, H. M.
name: Gilmore, G.
name: Alfaro, E.
name: Francois, P.
name: Korn, A.
name: Smiljanic, R.
name: Bergemann, M.
name: Franciosini, E.
name: Gonneau, A.
name: Hourihane, A.
name: Worley, C. C.
name: Zaggia, S.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The last decade has seen a revolution in our knowledge of the Galaxy thanks to the Gaia and asteroseismic space missions and the ground-based spectroscopic surveys. To complete this picture, it is necessary to map the ages of its stellar populations. During recent years, the dependence on time of abundance ratios involving slow (s) neutron-capture and $α$ elements (called chemical-clocks) has been used to provide estimates of stellar ages, usually in a limited volume close to the Sun. We aim to analyse the relations of chemical clocks in the Galactic disc extending the range to R$_{\rm GC}\sim$6-20~kpc. Using the sixth internal data release of the Gaia-ESO survey, we calibrated several relations between stellar ages and abundance ratios [s/$α$] using a sample of open clusters, the largest one so far used with this aim. Thanks to their wide galactocentric coverage, we investigated the radial variations of the shape of these relations, confirming their non-universality. We estimated our accuracy and precision in recovering the global ages of open clusters, and the ages of their individual members. We applied the multi-variate relations with the highest correlation coefficients to the field star population. We confirm that there is no single age-chemical clock relationship valid for the whole disc, but that there is a dependence on the galactocentric position, which is related to the radial variation of the star formation history combined with the non-monotonic dependence on metallicity of the yields of the s-process elements from low- and intermediate-mass stars. Finally, the abundance ratios [Ba/$α$] are more sensitive to age than those with [Y/$α$] for young disc stars, and their slopes vary less with galactocentric distance.
description: 14 pages, 10 figures + Appendix (3 tables and 2 figures)
CESSDA SaW D2.3: Stakeholder workshop report 1
Creators: name: Paton, Nathalie
name: Milon, Jean-Baptiste
name: Ilijasic Versic, Ivana
name: Hegedus, Peter
name: Priddy, Mike
name: Tjalsma, Heiko
name: Beagrie, Neil
Publisher: name: Zenodo
Year: 2016
Subjects: Strategy and Policy
Trust and Certification
Workshop

description: Report on the “Training on Trust, Identifying Demand & Networking” workshop held in The Hague, Netherlands, on June 15th and 16th, 2016 in respect with the organizational process behind the setup of this workshop as well as the outcomes of this preparation, and outline of all sessions during 2 days.
Two new halogenated sesquiterpene lactones from Palisada intermedia
Creators: name: Doan, Vuong Trung
name: Pham, Van Thong
name: Le, Chi Hien Dat
name: Luu, Thi Thanh Nhan
name: Dam, To Uyen
name: Le, Ho Khanh Hy
name: That, Quang Ton
name: Nguyen, Kim Phi Phung
name: Ngo, Thi Thuy Duong
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Two new sesquiterpene lactones, laurenolide A (1) and laurenolide B (2), along with six known compounds, palmitic acid (3), (R,R)-hexahydrofarnesyl acetone (4), trans-phytol acetate (5), cholesterol (6), cholesteryl acetate (7), cholesteryl heptadecanoate (8) were isolated from Palisada intermedia. The chemical structures of all compounds were elucidated by 1D and 2D-NMR spectroscopy and HR-ESI-MS analysis as well as compared with data in the literature. The petroleum ether, chloroform, ethyl acetate, methanol extracts and compounds 1, 2 were tested for the inhibition of two cancer cell lines MCF-7, NCI-H460 and they showed weak or none activities.
XR4HUMAN D8.3: Promotional Video, first batch
Creators: name: Stavridi, Vana
name: Kavouras, Panagiotis
Publisher: name: Zenodo
Year: 2023

description: Within the framework of the dissemination and communication activities for XR4Human in collaboration with coordinators, WP8 worked to develop the 1st promotional video for the project. As set out in the Grant Agreement, the promotional video supports the dissemination and communication effort of the project. It aims to raise awareness of the project. The 1 st promotional video presents a summary of the project, its objectives as well as the project main outputs. It mainly targets non-expert audience and captures all basic elements of XR4Human project though pictures of real people and some antimations. The video will be made available on the project website and project YouTube channel.