title: ÐÐ½Ð°Ð»Ð¸Ð· Ð²Ð¾Ð·Ð½Ð¸ÐºÐ½Ð¾Ð²ÐµÐ½Ð¸Ñ Ð»ÑÑÐµÐ²ÑÑ Ð¾ÑÐ»Ð¾Ð¶Ð½ÐµÐ½Ð¸Ð¹ Ð¿ÑÐ¸ Ð²ÑÑÐ¾ÐºÐ¾Ð´Ð¾Ð·Ð½Ð¾Ð¼ ÑÑÐµÑÐµÐ¾ÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ¾Ð¼ Ð¾Ð±Ð»ÑÑÐµÐ½Ð¸Ð¸ Ð¼ÐµÑÐ°ÑÑÐ°ÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¾Ð¿ÑÑ Ð¾Ð»ÐµÐ¹ Ð² Ð³Ð¾Ð»Ð¾Ð²Ð½Ð¾Ð¼ Ð¼Ð¾Ð·Ð³Ðµ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Analysis of radiation complications after high-dose stereotactic irradiation of metastatic brain tumors
Creators: name: Ð¡Ð°ÑÐ¸ÑÐ»Ð»Ð¸Ð½Ð°, ÐÐ°ÑÐ¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: Ð¼ÐµÑÐ°ÑÑÐ°Ð·Ñ Ð² Ð³Ð¾Ð»Ð¾Ð²Ð½Ð¾Ð¹ Ð¼Ð¾Ð·Ð³
Ð¾ÑÐ°Ð³Ð¸ Ð±Ð¾Ð»ÑÑÐ¾Ð³Ð¾ Ð¾Ð±ÑÑÐ¼Ð°
ÑÐ°Ð´Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ð¹ Ð¾ÑÐ²ÐµÑ
Ð»ÑÑÐµÐ²Ð¾Ð¹ Ð½ÐµÐºÑÐ¾Ð·
Ð³Ð¸Ð¿Ð¾ÑÑÐ°ÐºÑÐ¸Ð¾Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ
ÑÑÐµÑÐµÐ¾ÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ¾Ðµ Ð²ÑÑÐ¾ÐºÐ¾Ð´Ð¾Ð·Ð½Ð¾Ðµ Ð¾Ð±Ð»ÑÑÐµÐ½Ð¸Ðµ
ÐºÐ¸Ð±ÐµÑ-Ð½Ð¾Ð¶
brain metastases
large tumor volume
radiological response
radiation necrosis
hypofractionation
stereotactic high-dose irradiation
cyberknife

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description: The subject of the graduate qualification work is âAnalysis of radiation complications after high-dose stereotactic irradiation of metastatic brain tumorsâ. The given work is dedicated to evaluate the effects of dosimetric parameters of treatment plans and parameters of metastatic tumors on the occurrence of post-radiation complications (radiation necrosis) after hypofractionated stereotactic high-dose irradiation. The study included 92 patients and analyzed 148 metastatic tumors treated with the CyberKnife in the Medical Institute named after Berezin Sergey (MIBS) oncology clinic. The criteria for inclusion of patients in the study were the presence of at least one metastasis in the brain treated with hypofractionation and control magnetic resonance examinations, as well as the absence of previous radiation treatment in the form of whole brain radiation therapy (WBRT). The mean volume of metastatic tumors was 18.5 cm3. The prescribed dose of 24-30 Gy was delivered in three fractions. According to the study results, the volume of the metastatic tumor and the interval between fractions were statistically significant factors for the appearance of radiation necrosis. Taking these parameters into consideration, it is possible to optimize the choice of the radiation regimen in order to minimize radiation reactions while maintaining high level of local control.