cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Metallodrugs for therapy and imaging : investigation of their mechanism of action
Creators: name: Spreckelmeyer, Sarah
Publisher: name: University of British Columbia
Year: 2019

description: In this thesis, the application of metallodrugs for therapy and imaging was investigated as part of the field of medicinal inorganic chemistry. In the introduction, an overview was given on the application of organic molecules, incorporating a metal or radiometal for either therapeutic or diagnostic purposes, particularly in relation to cancer. It is evident that their mechanism of action, their pharmacokinetic behaviour and biological targets are mostly not fully elucidated yet. Thus, our overall aims included: i) to synthesize new radiopharmaceuticals for either cancer therapy or imaging, and ii) to elucidate the mechanism of cellular uptake and excretion, the anti-cancer activity and the organ toxicity of some new Au containing metallodrugs in comparison to cisplatin. To investigate the toxicity and transport mechanisms of the new cytotoxic organometallic Au(III) compounds, the ex vivo model of precision cut tissue slices and human cell cultures in vitro were used. The work described in Part A was performed at the University of British Columbia in Vancouver, BC, Canada in the Department of Medicinal Inorganic Chemistry under the supervision of Prof. Chris Orvig. Different radiotracers were developed and characterized by chemical-physical methods. Radiolabeling experiments were also performed at TRIUMF (Canada’s national laboratory for particle and nuclear physics and accelerator-based science) and in vivo animal experiments were conducted at the BC Cancer Agency. In chapter A1, we report on the synthesis of H₄neunpa and its immunoconjugate H₄neunpa-trastuzumab (Figure 1) and showed that it can be efficiently radiolabeled with ¹¹¹In³⁺ at ambient temperature within 15 min or 30 min, respectively. ¹¹¹In is a gamma emitter and can thus be used for single photon emission computed tomography (SPECT). The immunoconjugate was further investigated in an in vivo model using HER2/neu positive subcutaneous SKOV-3 ovarian cancer xenografts bearing mice. Unfortunately, our results showed an unexpected lower accumulation of 111Inneunpa- trastuzumab into the tumor compared to the gold-standard ¹¹¹In-CHX-DTPA-trastuzumab, which was supported by Immuno-SPECT images taken after 1 day, 3 days and 5 day post injection. Consequently, ¹¹¹In-neunpa-trastuzumab does not seem to be suitable for clinical application, although in vitro experiments (immunoreactivity, radiolabeling efficiencies, stability in human serum) showed similar or superior properties of this chelator compared to the goldstandard. A reason for this lower accumulation might be a difference in internalization process of the chelator- HER2/neu-receptor complex. Finally, radiolabeling of H₄neunpa with ¹⁷⁷Lu, a therapeutic radiometal, was tried but appeared unsuccessful. Comparison of In³⁺ (92pm CN=8) and Lu³⁺ (103pm CN=9)¹ leads to the hypothesis that either Lu³⁺ might be too big for H₄neunpa or the preferred coordination number is not saturated because of steric hindrance.
Conservation laws, integrability and transport in one-dimensional quantum systems
Creators: name: Sirker, J.
name: Pereira, R. G.
name: Affleck, I.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: In integrable one-dimensional quantum systems an infinite set of local conserved quantities exists which can prevent a current from decaying completely. For cases like the spin current in the XXZ model at zero magnetic field or the charge current in the attractive Hubbard model at half filling, however, the current operator does not have overlap with any of the local conserved quantities. We show that in these situations transport at finite temperatures is dominated by a diffusive contribution with the Drude weight being either small or even zero. For the XXZ model we discuss in detail the relation between our results, the phenomenological theory of spin diffusion, and measurements of the spin-lattice relaxation rate in spin chain compounds. Furthermore, we study the Haldane-Shastry model where the current operator is also orthogonal to the set of conserved quantities associated with integrability but becomes itself conserved in the thermodynamic limit.
description: 22 pages, 9 figures
Science-driven Autonomous & Heterogeneous Robotic Networks: A Vision for Future Ocean Observations
Creators: name: Thompson, Andrew F.
name: Chien, Steve
name: Chao, Yi
name: Kinsey, James
Publisher: name: Keck Institute for Space Studies
Year: 2018

description: The goal of this project was to develop the first algorithms that allow a heterogeneous group of oceanic robots to autonomously determine and implement sampling strategies with the help of numerical ocean forecasts and remotely-sensed observations. Two-way feedback with shore-based numerical models, tested in the field, had not previously been attempted. New planning algorithms were tested during two field programs in Monterey Bay during a 12-month period using three different types of autonomous vehicles.
Precession effect of the gravitational self-force in a Schwarzschild spacetime and the effective one-body formalism
Creators: name: Barack, Leor
name: Damour, Thibault
name: Sago, Norichika
Publisher: name: arXiv
Year: 2010
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Using a recently presented numerical code for calculating the Lorenz-gauge gravitational self-force (GSF), we compute the $O(m)$ conservative correction to the precession rate of the small-eccentricity orbits of a particle of mass $m$ moving around a Schwarzschild black hole of mass ${\mathsf M}\gg m$. Specifically, we study the gauge-invariant function $ρ(x)$, where $ρ$ is defined as the $O(m)$ part of the dimensionless ratio $(\hatΩ_r/\hatΩ_φ)^2$ between the squares of the radial and azimuthal frequencies of the orbit, and where $x=[Gc^{-3}({\mathsf M}+m)\hatΩ_φ]^{2/3}$ is a gauge-invariant measure of the dimensionless gravitational potential (mass over radius) associated with the mean circular orbit. Our GSF computation of the function $ρ(x)$ in the interval $0
description: 25 pages, 5 eps figures
Electrolyte-supported solid oxide fuel cells for gas sensing applications
Creators: name: Venkatesan, Vijay
Publisher: name: Loughborough University
Year: 2021
Subjects: classificationCode: 409999
subject: Other engineering not elsewhere classified

description: Solid Oxide Fuel Cells show an ability to generate voltage and current outputs proportional to the type and concentration of fuel being supplied, and hence show sensitivity to these measures. The single chamber concept of fuel cell sidesteps or simplifies many issues with present conventional SOFCs such as separation of fuel and air/oxygen streams, sealing requirements and thermal shock resistance. Fuel utilization and output is compromised, but this concept may be well suited to being used as a sensor, as maximum power density is not of prime importance. Thus far, sensor design and fabrication has focused on dedicated design and materials, whilst minimizing the electrolyte thickness for quick response. Electrolyte support still offers mechanical robustness, ready adaptability, handling and possible material stability. At present, these meritorious characteristics are often overlooked in favour of minimised ohmic resistance from other support structures. The electrolyte supported cell was chosen on this basis to be the evaluated platform in this study. Commercially-sourced planar electrolyte-supported cells were tested for two prospective sensing functions: (i) air-fuel ratio switching in single chamber and split-chamber configurations and (ii) hydrogen sensing in methane bulk gas, to anticipate the advent of Power-to-Gas hydrogen storage in the natural gas grid. The preliminary analysis concludes that the cell displays provisionally good sensitivity for gas species in both OCV and amperometric modes. Amperometric outputs under voltage bias produced better sensing performance, but overall results were either nonreproducible, subject to drift or are insufficiently responsive for the Air-fuel sensing case when compared to the state-of-the-art oxygen sensors. Deployment in split-chamber configuration showed more promise as a hydrogen content sensor in natural gas, especially operated in amperometric mode under voltage bias. Dedicated design, engineering and analysis is needed to maximize the sensitivity of non-specialized cells such as these to be employed as functional and reliable sensing devices. The research performed concludes that a promising route is towards a multi-channel or distributed gas flow arrangement to parse and disaggregate the sensor responses to individual gases, but the cell should be operated at a lower temperature and higher current draw to mitigate coking and degradation with the present material construction.
Synthesis, anticancer evaluation and molecular docking studies of new benzimidazole- 1,3,4-oxadiazole derivatives as human topoisomerase types I poison
Creators: name: Çevik, Ulviye Acar
name: Sağlık, Begüm Nurpelin
name: Osmaniye, Derya
name: Levent, Serkan
name: Çavuşoğlu, Betül Kaya
name: Karaduman, Abdullah Burak
name: Atlıd, Özlem
name: Eklioğlu, Özlem Atlı
name: Kaplancıklı, Zafer Asım
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: In this study, some benzimidazole-oxadiazole derivatives were synthesised and tested for their in vitro anticancer activities on five cancer cell lines, including HeLa, MCF7, A549, HepG2 and C6. Their structures were elucidated by IR, 1H-NMR, 13C-NMR, 2 D-NMR and HRMS spectroscopic methods. Among all screened compounds; 5a, 5b, 5d, 5e, 5k, 5l, 5n and 5o exhibited potent selective cytotoxic activities against various tested cancer cell lines. Especially, compounds 5l and 5n exhibited the most antiproliferative activity than Hoechst 33342 and doxorubicin against HeLa cell line, with IC50 of 0.224 ± 0.011 µM and 0.205 ± 0.010 µM, respectively. Furthermore, these potent lead cytotoxic agents were evaluated in terms of their inhibition potency against Topoisomerase I and it was determined that selected compounds inhibited the Topoisomerase I. Docking studies were performed and probable interactions in the DNA-Topo I enzyme complex was determined.
T-Carbon: A Novel Carbon Allotrope
Creators: name: Sheng, Xian-Lei
name: Yan, Qing-Bo
name: Ye, Fei
name: Zheng, Qing-Rong
name: Su, Gang
Publisher: name: arXiv
Year: 2011
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: A structurally stable crystalline carbon allotrope is predicted by means of the first-principles calculations. This allotrope can be derived by substituting each atom in diamond with a carbon tetrahedron, and possesses the same space group Fd^1 3m as diamond, which is thus coined as T- carbon. The calculations on geometrical, vibrational and electronic properties reveal that T-carbon, with a considerable structural stability and a much lower density 1.50 g/cm3, is a semiconductor with a direct band gap about 3.0 eV, and has a Vickers hardness 61.1 GPa lower than diamond but comparable with cubic boron nitride. Such a form of carbon, once obtained, would have wide applications in photocatalysis, adsoption, hydrogen storage and aerospace materials.
Landau levels and magnetopolaron effect in dilute GaAs:N
Creators: name: Krstajić, P. M.
name: Helm, M.
name: Peeters, F.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: The magnetic-field dependence of the energy spectrum of GaAs doped with nitrogen impurities is investigated. Our theoretical model is based on the phenomenological Band Anticrossing Model (BAC) which we extended in order to include magnetic field and electron - phonon interaction. Due to the highly localized nature of the nitrogen state, we find that the energy levels are very different from those of pure GaAs. The polaron correction results in a lower cyclotron resonance energy as compared to pure GaAs. The magneto-absorption spectrum exhibits series of asymmetric peaks close to the cyclotron energy.
Semi-Supervised Semantic Segmentation for Agricultural Aerial Images
Creators: name: Lu, Chen-yi
Publisher: name: Purdue University Graduate School
Year: 2023
Subjects: Computer vision
Other agricultural, veterinary and food sciences not elsewhere classified
Deep learning

description: Unmanned Aerial Systems (UAS) have been an essential tool for field scouting, nutrient applications, and farm management. However, assessing the aerial images captured by UAS is labor-intensive, and human assessment can be misleading, introducing bias. Deep learning based image segmentation has been proposed to assist in segmenting different areas of interest in the field, but it usually requires significant pixel-level annotated data. To address this, we propose a semi-supervised learning algorithm, AgSemSeg, to train a robust image segmentation model with less annotated data. Semi-supervised semantic segmentation aims to predict accurate pixel-level segmentation results via incorporating unlabeled images. Existing methods rely on computing the consistency loss on the output predictions between pseudo-labels and unlabeled images. In AgSemSeg, we exploit the intermediate feature representations rather than only using the output predictions to improve the overall performance of the model. Specifically, we add a projection layer on the output of the backbone encoder, and inject consistency loss between intermediate feature representations with Sliced-Wasserstein distance. We evaluate AgSemSeg using Agriculture-Vision dataset and outperform the supervised baseline by up to 9.71%. We also evaluate AgSemSeg on benchmark datasets such as PASCAL VOC 2012 and Cityscapes datasets, and it outperforms supervised baselines by up to 24.6% and 7.5% mIoU, respectively. We also perform extensive ablation studies to show that our proposed components are key to the performance improvements of our method.
The structure of graphite oxide: Investigation of its surface chemical groups
Creators: name: Lee, D. W.
name: V., L. De Los Santos
name: Seo, J. W.
name: Felix, L. Leon
name: D., A. Bustamante
name: Cole, J. M.
name: ~Barnes, C. ~H. ~W.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The structure of graphite oxide (GO) has been systematically studied using various tools such as SEM, TEM, XRD, Fourier transform infrared spectroscopy (FT-IR), X-ray photoemission spectroscopy (XPS), 13C solid state NMR, and O K-edge X-ray absorption near edge structure (XANES). The TEM data reveal that GO consists of amorphous and crystalline phases. The XPS data show that some carbon atoms have sp3 orbitals and others have sp2 orbitals. The ratio of sp2 to sp3 bonded carbon atoms decreases as sample preparation times increase. The 13C solid-state NMR spectra of GO indicate the existence of -OH and -O- groups for which peaks appear at 60 and 70 ppm, respectively. FT-IR results corroborate these findings. The existence of ketone groups is also implied by FT-IR, which is verified by O K-edge XANES and 13C solid-state NMR. We propose a new model for GO based on the results; -O-, -OH, and -C=O groups are on the surface.
description: J. Phys. Chem. B 2010, 114, 5723-5728
title:   EFFECT OF MENSTRUAL CYCLE PHASE ON THE REWARDING PROPERTIES OF ALCOHOL IN WOMEN
Creators: name: Griffith, Annie
Publisher: name: University of Kentucky Libraries
Year: 2023
Subjects: subject: FOS: Psychology
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Compared with men, women are disproportionately affected by alcohol, including greater risks of behavioral impairment and relapse. One likely mechanism underlying this disparity is fluctuations of ovarian hormones, particularly estradiol (E2), across phases of the menstrual cycle. Pre-clinical and clinical studies have shown that higher E2 levels correlate with heavier patterns of alcohol consumption, suggesting E2 may modulate drinking. This relationship is thought to be mediated by the rewarding properties of alcohol. The present thesis tested the hypothesis that elevated E2 during the late follicular phase would increase the rewarding properties of alcohol. Fifty young-adult women participated in a within-subjects placebo-controlled study of the acute effect of 0.6 g/kg alcohol on the rewarding properties of alcohol, measured by attentional bias towards alcohol and subjective reports. Measures were obtained following alcohol and placebo during the early follicular phase of the cycle when E2 was low and the late follicular phase (i.e., ovulation) when E2 was elevated. Results showed that the rewarding effect of alcohol was greater during the late follicular phase. These findings highlight the rewarding properties of alcohol as a potential mechanism by which elevated E2 during the late follicular phase might exacerbate risk for excessive alcohol use among women.
description: © 2023 Annie K. Griffith
3D-Simulation of Novel Quantum Wire Transistors
Creators: name: Wegscheider, Werner
name: Pigorsch, C.
name: Klix, W.
name: Stenzel, R.
Publisher: name: Universität Regensburg
Year: 1997
Subjects: subject: 530 Physik
subject: 73.40.Lq; 73.61.±r

description: The output characteristics and the electronic behaviour of a quantum wire transistor (QWT) with a 1DEG channel have been simulated. The electron transport processes in the QWT are mainly influenced by quantum mechanical effects. A coupled microscopic/macroscopic simulation algorithm is used to calculate the electron density distribution in the electron gas under consideration of the confinement of the electrons. This algorithm includes the self-consistent solution of the Poisson and the Schrödinger equation.
A class of singular logarithmic potentials in a box with variety of skin thickness and wall interaction
Creators: name: Alhaidari, A. D.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We obtain an analytic solution for a three-parameter class of logarithmic potentials at zero energy. The potential terms are products of the inverse square and the inverse log to powers 2, 1 and 0. The configuration space is the one-dimensional box. Using point canonical transformation, we simplify the solution by mapping the problem into the oscillator problem. We also obtain an approximate analytic solution for non-zero energy when there is strong attraction to one side of the box. The wavefunction is written in terms of the confluent hypergeometric function. We also present a numerical scheme to calculate the energy spectrum for a general configuration and to any desired accuracy.
description: 9 pages, 5 figures, 3 tables
New classes of potent heparanase inhibitors from ligand-based virtual screening
Creators: name: Pala, Daniele
name: Scalvini, Laura
name: Elisi, Gian Marco
name: Lodola, Alessio
name: Mor, Marco
name: Spadoni, Gilberto
name: Ferrara, Fabiana F.
name: Pavoni, Emiliano
name: Roscilli, Giuseppe
name: Milazzo, Ferdinando M.
name: Battistuzzi, Gianfranco
name: Rivara, Silvia
name: Giannini, Giuseppe
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Hematology

description: Heparanase is a validated target in cancer therapy and a potential target for several inflammatory pathologies. A ligand-based virtual screening of commercial libraries was performed to expand the chemical space of small-molecule inhibitors. The screening was based on similarity with known inhibitors and was performed in several runs, starting from literature compounds and progressing through newly discovered inhibitors. Among the fifty-five tested compounds, nineteen had IC50 values lower than 5 µM and some showed remarkable potencies. Importantly, tere- and isophthalamides derivatives belong to new structural classes of heparanase inhibitors and some of them showed enzyme affinities (61 and 63, IC50 = 0.32 and 0.12 µM, respectively) similar to those of the most potent small-molecule inhibitors reported so far. Docking studies provided a comprehensive binding hypothesis shared by compounds with significant structural diversity. The most potent inhibitors reduced cell invasiveness and inhibited the expression of proangiogenic factors in tumour cell lines.
The Edwards-Wilkinson equation with drift and Neumann boundary conditions
Creators: name: Cheang, Seng
name: Pruessner, Gunnar
Publisher: name: arXiv
Year: 2010
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: The well known scaling of the Edwards-Wilkinson equation is essentially determined by dimensional analysis. Once a drift term is added, more sophisticated reasoning is required, which initially suggests that the drift term dominates over the diffusion. However, the diffusion term is dangerously irrelevant and the resulting scaling in fact non-trivial. In the present article we compare the resulting scaling of the Edwards-Wilkinson equation with drift and Neumann boundary conditions to the published case with Dirichlet boundary conditions.
description: 20 pages, IOP style article, in version 2 minor mistakes and typos corrected
Gene expression analysis of overwintering mountain pine beetle larvae suggests multiple systems involved in overwintering stress, cold hardiness, and preparation for spring development
Creators: name: Robert, Jeanne A.; Bonnett, Tiffany R.; Pitt, Caitlin; Spooner, Luke J.; Fraser, Jordan D.; Yuen, Macaire M. S.; Keeling, Christopher I.; Bohlmann, Jorg; Huber, Dezene P. W.
Publisher: name: University of Alberta Libraries
Year: 2016

Abstract
Effects of isovaline and involvement of metabotropic group ii glutamate receptors
Creators: name: Asseri, Khalid A. A.
Publisher: name: University of British Columbia
Year: 2019

description: This thesis is comprised of manuscripts describing effects of isovaline, metabotropic GABAB agonist, baclofen, and metabotropic glutamate (mGlu II) agonist, LY354740, on peripheral and central neurons. Our laboratory studies previously demonstrated analgesic properties of isovaline acting on peripheral GABAB receptors while in brain slices, isovaline acted as atypical GABAB agonist. Peripheral GABAB and mGlu II receptors belong to same family of G-protein-coupled receptors. We examined if isovaline activated peripheral mGlu II receptors that inhibit nociception. We assessed post- and presynaptic effects of isovaline, with comparison to baclofen and LY354740 on neurons of somatosensory thalamus. We compared effects of isovaline, baclofen and LY354740 on electrically evoked contractions of guinea-pig ileum, a standard assay for GABAB receptors. In manuscript one, we hypothesized that mGlu II receptors mediate isovaline analgesia. We utilized a model of pain induced by prostaglandin-E2 which sensitizes primary afferent fibers in hindpaw of mice. Isovaline produced analgesia which was blocked by mGlu II antagonist (LY341495). Therefore isovaline activated peripheral mGlu II receptors, in addition to GABAB receptors. In manuscript two, we hypothesized that isovaline activates presynaptic GABAB and mGlu II receptors, thereby inhibiting GABA and glutamate release. We studied effects of isovaline, baclofen and LY354740 on inhibitory and excitatory postsynaptic currents (IPSCs and EPSCs) in thalamocortical neurons. We determined effects on electrically stimulated release of transmitters which we confirmed as producing GABAergic and glutamatergic currents. The agonists decreased amplitudes of IPSCs and EPSCs during selective blockade of other postsynaptic currents, without affecting decay-time constants. GABAB antagonist (CGP52432) and LY341495 blocked isovaline effects, implicating GABAB and mGlu II receptors in transmitter release inhibition. In manuscript three, we hypothesized that isovaline activates ileal GABAB and mGlu II receptors. Isovaline decreased amplitude of muscle contractions and increased resting tension. CGP52432 antagonized baclofen-induced decreases in amplitude and tension, but not isovaline effects. LY354740 had no effect. These findings suggest novel targets for isovaline-like compounds in ileum. The thesis demonstrates for the first time that isovaline produces analgesia in hindpaw and presynaptic inhibition in thalamus by activating mGlu II in addition to GABAB receptors, while isovaline receptors are distinct from GABAB receptors in ileum.
Systematic errors in extracting nucleon properties from lattice QCD
Creators: name: Capitani, Stefano
name: Della Morte, Michele
name: Knippschild, Bastian
name: Wittig, Hartmut
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: Form factors of the nucleon have been extracted from experiment with high precision. However, lattice calculations have failed so far to reproduce the observed dependence of form factors on the momentum transfer. We have embarked on a program to thoroughly investigate systematic effects in lattice calculation of the required three-point correlation functions. Here we focus on the possible contamination from higher excited states and present a method which is designed to suppress them. Its effectiveness is tested for several baryonic matrix elements, different lattice sizes and pion masses.
description: 7 pages, 8 figures
On the controllability of the Vlasov-Poisson system in the presence of external force fields
Creators: name: Glass, Olivier
name: Han-Kwan, Daniel
Publisher: name: arXiv
Year: 2011
Subjects: subject: Analysis of PDEs (math.AP)
subject: Systems and Control (eess.SY)
subject: Optimization and Control (math.OC)
subject: FOS: Mathematics
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In this work, we are interested in the controllability of Vlasov-Poisson systems in the presence of an external force field (namely a bounded force field or a magnetic field), by means of a local interior control. We are able to extend the results of [7], where the only present force was the self-consistent electric field.
Relativistic Coulomb problem for Z larger than 137
Creators: name: Alhaidari, A. D.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Physics (quant-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We propose a relativistic one-parameter Hermitian theory for the Coulomb problem with an electric charge greater than 137. In the non-relativistic limit, the theory becomes identical to the Schrödinger-Coulomb problem for all Z. Moreover, it agrees with the Dirac-Coulomb problem to order (\alph Z)^2, where αis the fine structure constant. The vacuum in the theory is stable and does not suffer from the "charged vacuum" problem for all Z. Moreover, transition between positive and negative energy states could be eliminated. The relativistic bound states energy spectrum and corresponding spinor wavefunctions are obtained.
description: 12 pages, 4 figures
Understanding interface effects in perovskite thin films
Creators: name: Lepetit, Marie-Bernadette
name: Mercey, Bernard
name: Simon, Charles
Publisher: name: arXiv
Year: 2011
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The control of matter properties (transport, magnetic, dielectric,...) using synthesis as thin films is strongly hindered by the lack of reliable theories, able to guide the design of new systems, through the understanding of the interface effects and of the way the substrate constraints are imposed to the material. The present paper analyses the energetic contributions at the interfaces, and proposes a model describing the microscopic mechanisms governing the interactions at an epitaxial interface between a manganite and another transition metal oxide in perovskite structure (as for instance $\rm SrTiO_3$). The model is checked against experimental results and literature analysis.
A worm-inspired algorithm for the simulation of Abelian gauge theories
Creators: name: Korzec, Tomasz
name: Wolff, Ulli
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We present an algorithm in which the all-order strong coupling expansion of the Abelian U(1) gauge theory with Wilson plaquette action is sampled. In addition to the vacuum closed surface graphs of the partition function we propose to also allow for a class of defects (boundaries) related to Wilson loops in the ensemble. The efficiency of our scheme in estimating various observables is compared to a standard Metropolis algorithm.
description: 7 pages, 2 figures. Presented at the XXVIII International Symposium on Lattice Field Theory (Lattice 2010), June 14-19 2010, Villasimius, Italy
Finite-dimensional subalgebras in polynomial Lie algebras of rank one
Creators: name: Arzhantsev, I. V.
name: Makedonskii, E. A.
name: Petravchuk, A. P.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Rings and Algebras (math.RA)
subject: FOS: Mathematics
subject: 17B66, 16W25, 17A36

description: Let W_n(K) be the Lie algebra of derivations of the polynomial algebra K[X]:=K[x_1,...,x_n] over an algebraically closed field K of characteristic zero. A subalgebra L of W_n(K) is called polynomial if it is a submodule of the K[X]-module W_n(K). We prove that the centralizer of every nonzero element in L is abelian provided L has rank one. This allows to classify finite-dimensional subalgebras in polynomial Lie algebras of rank one.
description: 5 pages
Discovery of 3,6-disubstituted pyridazines as a novel class of anticancer agents targeting cyclin-dependent kinase 2: synthesis, biological evaluation and in silico insights
Creators: name: Sabt, Ahmed
name: Eldehna, Wagdy M.
name: Al-Warhi, Tarfah
name: Alotaibi, Ohoud J.
name: Elaasser, Mahmoud M.
name: Suliman, Howayda
name: Abdel-Aziz, Hatem A.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer

description: Human health in the current medical era is facing numerous challenges, especially cancer. So, the therapeutic arsenal for cancer should be unremittingly enriched with novel small molecules that selectively target tumour cells with minimal toxicity towards normal cells. In this context, herein a new series of 3,6-disubstituted pyridazines 11a–r has been synthesised and evaluated for in vitro anticancer activity. They possessed good anti-proliferative action towards human breast cancer T-47D (IC50 range: 0.43 ± 0.01 − 35.9 ± 1.18 µM) and MDA-MB-231 (IC50 range: 0.99 ± 0.03 − 34.59 ± 1.13 µM) cell lines, whereas they displayed weak activity against the tested ovarian cancer cell line SKOV-3. Among the studied compounds, the methyltetrahydropyran-bearing pyridazine 11m emerged as the unique submicromolar growth inhibitor herein reported towards both T-47D (IC50 = 0.43 ± 0.01 µM) and MDA-MB-231 (IC50 = 0.99 ± 0.03 µM) cell lines. In addition, the biological results indicated that pyridazines 11l and 11m exerted an efficient alteration within the cell cycle progression as well as induction of apoptosis in both T-47D and MDA-MB-231 cells. Moreover, pyridazines 11l and 11m displayed good mean tumour S. I. values of 13.7 and 16.1 upon assessment of their cytotoxicity towards non-tumorigenic breast MCF-10A cells. Furthermore, an in silico study proposed CDK2 as a probable enzymatic target for pyridazines 11, and explored their binding interactions within the vicinity of CDK2 binding site. Subsequently, pyridazines 11e, 11h, 11l, and 11m were selected to be evaluated for their ability to inhibit CDK2, where they exerted good inhibitory activity (IC50 = 151, 43.8, 55.6 and 20.1 nM, respectively). Finally, the in silico study implied that target pyridazines 11 exhibited not only an efficient anticancer activity but also an acceptable ADME, physicochemical and druglikeness properties, specifically pyridazines 11l and 11m. Overall the obtained results from this study quite sustained our strategy and gave us a robust opportunity for further development and optimisation of 3,6-disubstituted pyridazine scaffold to enrich therapeutic arsenal with efficient and safe anticancer CDK inhibitors.
Statistical approach of parton distributions: a closer look at the high-$x$ region
Creators: name: Soffer, Jacques
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We recall the physical features of the parton distributions in the quantum statistical approach of the nucleon, which allows to describe simultaneously, unpolarized and polarized Deep Inelastic Scattering data. Some predictions from a next-to-leading order QCD analysis are compared to recent experimental results and we stress the importance of some tests in the high-$x$ region, to confirm the validity of this approach.
description: 9 pages, 5 figures, Invited talk at the 3rd Int. Workshop on Nucleon Structure at Large Bjorken x, "`HiX2010"', Jefferson Lab., Newport News, Virginia, USA, October 13 - 15, 2010, to appear in the AIP Conference Proceedings
title:   ETHANOL DECREASES EXPRESSION OF DEVELOPING NEURONS, BUT NOT NEURONAL VIABILITY, IN A CULTURED RAT HIPPOCAMPUS
Creators: name: Count, Cassidy
Publisher: name: University of Kentucky Libraries
Year: 2023
Subjects: subject: FOS: Psychology
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: As of 2019, alcohol use disorders (AUDs) affect roughly 14.1 million individuals over the age of 18 and cost up to $249 billion in economic burden in the United States. In addition to central nervous system (CNS), those affected by AUDs can present with cognitive and behavioral abnormalities. Specifically, those affected by AUDs experience deficits in memory consolidation and retrieval as well as executive functioning, which may be due to cellular changes within the hippocampus. There are at least two prominent and contended theories which explain the mechanism of functional impairment caused by alcohol: 1) alcohol induces excitotoxic neuronal death in the hippocampus and/or 2) alcohol diminishes neurogenesis, reducing production and proliferation of new neuronal cells. Determining the relative involvement of neuronal death and neuronal production in alcohol-induced hippocampal dysfunction is necessary to inform potential therapeutic targets aiming to restore cognitive deficits caused by alcohol exposure. The purpose of this experiment is to examine the effects of continuous alcohol exposure and explore the relative contributions of each of these processes in the conformational changes in the hippocampus after chronic alcohol exposure and establish organotypic hippocampal slice culture as a viable method to continue exploring these changes.
description: © 2023 Cassidy Count
Maximal theorems and square functions for analytic operators on Lp-spaces
Creators: name: Merdy, Christian Le
name: Xu, Quanhua
Publisher: name: arXiv
Year: 2010
Subjects: subject: Functional Analysis (math.FA)
subject: Operator Algebras (math.OA)
subject: FOS: Mathematics
subject: 47B38, 46L52, 46A60

description: Let T : Lp --> Lp be a contraction, with p strictly between 1 and infinity, and assume that T is analytic, that is, there exists a constant K such that n\norm{T^n-T^{n-1}} < K for any positive integer n. Under the assumption that T is positive (or contractively regular), we establish the boundedness of various Littlewood-Paley square functions associated with T. As a consequence we show maximal inequalities of the form $\norm{\sup_{n\geq 0}\, (n+1)^m\bigl |T^n(T-I)^m(x) \bigr |}_p\,\lesssim\, \norm{x}_p$, for any nonnegative integer m. We prove similar results in the context of noncommutative Lp-spaces. We also give analogs of these maximal inequalities for bounded analytic semigroups, as well as applications to R-boundedness properties.
Phosphorus-modification of Pt-catalysts  boosts the catalytic performance in  cycloalkane dehydrogenation
Creators: name: Ellert, Abelina
name: Herold, Felix
name: Hutzler, Andreas
name: Janssens, Ton V. W.
name: Vennestrøm, Peter
name: Wasserscheid, Peter
name: Schühle, Patrick
Publisher: name: Zenodo
Year: 2023

description: In this study, novel P-modified Pt-catalysts supported on Al2O3 are synthesized, characterized and evaluated regarding their activity in cycloalkane dehydrogenation. The preparation involves two different methods, liquid and gas phase P-modification. Analytical techniques such as TEM, XRD, XPS and solid state NMR shed light on the nature of platinum and phosphorus in the catalyst. The catalytic performance of the materials in dehydrogenation of perhydro benzyltoluene (H12-BT) is evaluated and compared to non-doped Pt-catalysts. This work reveals that P-modification can boost the activity of Pt/Al2O3 in cycloalkane dehydrogenation.
LOTVS collection - metadata and proposal template
Creators: name: Sperandii, Marta Gaia
name: de Bello, Francesco
name: Valencia, Enrique
name: Götzenberger, Lars
name: Lepš, Jan
Publisher: name: Zenodo
Year: 2021
Subjects: LOTVS collection
permanent plots
ecosystem stability
vegetation time-series
plant communities

description: The folder contains a metadata sheet describing the datasets included in the LOTVS collection, and a proposal template to be used in data requests. Metadata will be regularly updated.
Polygamy and an absence of fine-scale structure in Dendroctonus ponderosae (Hopk) (Coleoptera: Curcilionidae) confirmed using molecular markers
Creators: name: Janes, J. K.; Roe, A. D.; Rice, A. V.; Gorrell, J. C.; Coltman, D. W.; Langor, D. W.; Sperling, F. A.
Publisher: name: University of Alberta Libraries
Year: 2016

Abstract
Excitons in T-shaped quantum wires
Creators: name: Glutsch, S.
name: Bechstedt, F.
name: Wegscheider, Werner
name: Schedelbeck, G.
Publisher: name: Universität Regensburg
Year: 1997
Subjects: subject: 530 Physik
subject: 71.35.-y, 78.66.-w

description: Binding energies and wave functions are calculated for the ground-state exciton in T-shaped quantum wires. It is shown that, if Coulomb interaction is taken into account, the hole is strongly localized by correlation with the electron. We demonstrate that no one-dimensional hole confinement is necessary for the formation of a one-dimensional exciton and that the exciton is roughly described by a two-dimensional hole, bound to a one-dimensional electron. Reasons are given for the shortcoming of the product Ansatz and the subband expansion for the pair wave function. For symmetric T structures with a thickness in the range from 5.4 to 7.0 nm, the calculated binding energies are larger than the values from approximate treatments, but smaller than the experimental results.
Distribution and diversity of aquatic RNA virus assemblages in an environmental context
Creators: name: Vlok, Marli
Publisher: name: University of British Columbia
Year: 2019

description: RNA viruses are ubiquitous and abundant in aquatic environments, but not well studied; of these, picorna-like viruses are dominant in coastal waters. They are genetically diverse, and primarily infect microbial eukaryotes; thereby, influencing microbial community composition and nutrient cycling. Few studies have elucidated the diversity of marine and freshwater RNA virus assemblages. In this dissertation, metagenomic data were used to address the hypothesis that aquatic RNA viruses are diverse and broadly distributed, as well as the abiotic factors and evolutionary pressures shaping these assemblages. Mapping reads from geographically separate sites to six reference genomes showed that these viruses were subject to purifying selection, with synonymous single-nucleotide variations dominating the mutations. These marine RNA viruses exhibited distinct biogeographic patterns with different quasispecies detectable in different areas. Marine RNA virus assemblages from polar to tropical environments were taxonomically complex. Viruses in the order Picornavirales were consistently in high relative abundance, and dominated marine RNA virus assemblages. Virus families that are thought to only occur in terrestrial systems were detected in oceanic samples, implying that these viruses infect marine organisms and, therefore, likely originated in the ocean. Freshwater RNA virus assemblages are equally diverse throughout six sites characterized by different associated land use. A complex suite of abiotic factors is associated with seasonal changes in viral diversity across all sites over 14 months, with high variability in site-specific RNA virus diversity. Certain viruses were associated with specific abiotic factors and sites, suggesting that some RNA viral taxa may be useful as indicator species. Lastly, a sequence-dependent taxonomic framework was developed to incorporate genomes assembled from metagenomic data into the current taxonomic classification system. This led to a proposed expansion of the Marnaviridae from a single isolate to 20 viruses classified into seven genera. The data presented here revealed unprecedented diversity in RNA aquatic viruses, and greatly expanded our knowledge of the distribution and dynamics of aquatic RNA viruses with consequent implications for understanding their role in aquatic ecosystems.
Supplementary document for Offset Lock with 440 GHz Range using Electro-Optic Modulation - 6067631.pdf
Creators: name: Zhou, Ocean
name: Neely, Andrew
name: Pagel, Zachary
name: Bernstein, Madeline
name: Roth, Jack
name: Mueller, Holger
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: Uncategorized

description: Supplemental document containing additional analysis and more details on experimental setup
MPEC 2023-J09 : 2023 HP7
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 HP7

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Quasi-biennial oscillations in the solar tachocline caused by magnetic Rossby wave instabilities
Creators: name: Zaqarashvili, T. V.
name: carbonell, M.
name: Oliver, R.
name: Ballester, J. L.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Quasi-biennial oscillations (QBO) are frequently observed in the solar activity indices. However, no clear physical mechanism for the observed variations has been suggested so far. Here we study the stability of magnetic Rossby waves in the solar tachocline using the shallow water magnetohydrodynamic approximation. Our analysis shows that the combination of typical differential rotation and a toroidal magnetic field with a strength > 10^5 G triggers the instability of the m=1 magnetic Rossby wave harmonic with a period of 2 years. This harmonic is antisymmetric with respect to the equator and its period (and growth rate) depends on the differential rotation parameters and the magnetic field strength. The oscillations may cause a periodic magnetic flux emergence at the solar surface and consequently may lead to the observed QBO in the solar activity features. The period of QBO may change throughout the cycle, and from cycle to cycle, due to variations of the mean magnetic field and differential rotation in the tachocline.
description: 13 pages, 4 figures, ApJ (in press)
Implementation of a marauding insect module (MIM, version 10) in the integrated bIosphere simulator (IBIS, version 26b4) dynamic vegetation–land surface model
Creators: name: Landry, Jean-Sebastion; Price, David T.; Ramankutty, Navin; Parrott, Lael; Matthews, H. Damon
Publisher: name: University of Alberta Libraries
Year: 2016

Abstract
title: „Krieg der Gelehrten“ und die Welt der Akademien 1914–1924
Creators: name: :None
Publisher: name: Wissenschaftliche Verlagsgesellschaft Stuttgart
Year: 2016
Subjects: subject: Wissenschaftsgeschichte
subject: Akademie der Wissenschaften
subject: Erster Weltkrieg
subject: 000
subject: 900

description: Acta historica Leopoldina, vol. 68
The roles of betacellulin in epithelial ovarian cancer migration and proliferation
Creators: name: Zhao, Jianfang
Publisher: name: University of British Columbia
Year: 2018

description: Epithelial ovarian cancer is the most lethal gynecological malignancy in developed countries. Although extensive studies have been done in the past decades to develop early detection methods and novel therapeutic strategies for epithelial ovarian cancer, 5-year survival rate of patients diagnosed in late stages remains lower than 30%. The epidermal growth factor (EGF) family of ligands and receptors is well-known for its roles in oncogenesis and cancer progression. As a unique member in this family, betacellulin has been shown to stimulate cell proliferation in several types of human tumors, and has also been suggested to associate with poor clinical outcome in breast cancer. However, little is known about the role and mechanism of betacellulin in epithelial ovarian cancer cell activities. In the current study, we hypothesized that betacellulin enhances epithelial ovarian cancer migration and proliferation by modulating several key target genes. Epithelial ovarian cancer cell lines OVCAR3, OVCAR4, OVCAR5 and SKOV3 were used as study models. Cancer cell migration was assessed by transwell assays; and cell proliferation was measured by MTT assays. Our results showed that betacellulin induced epithelial ovarian cancer cell migration by down-regulating E-cadherin and up-regulating Connexin43 expression; and these effects were mainly mediated by MEK/ERK and PI3K/Akt signaling via EGFR. Moreover, the potential role of ERBB4 in betacellulin signaling and ovarian cancer cell migration has also been suggested. On the other hand, we also demonstrated that betacellulin stimulated cell proliferation by up-regulating CCN1 expression. Taken together, our findings provide important insight into ovarian cancer biology and fill in the gaps of our knowledge of betacellulin, which may lead to the development of novel therapeutic tools for epithelial ovarian cancer.