cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
EUSO-SPB1: Flight data classification and Air Shower Search Results
Creators: name: Damian, Abraham Diaz
Publisher: name: arXiv
Year: 2019
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: The Extreme Universe Space Observatory on a Super Pressure Balloon (EUSO-SPB1) is the second balloon pathfinder of the JEM-EUSO collaboration. It is a nadir pointing UV telescope which aims at observing Ultra High Energy Cosmic Rays (UHECR) air showers through their fluorescence emission. It was launched the 24th of April, 2017, from the NASA balloon launch site in Wanaka, New Zealand. During its flight, EUSO-SPB1 took data during 12 moonless nights until the termination of the mission. In this paper we present events found in triggered data while searching for air showers. We classify these events into different populations whose characteristics and origins we discuss. We show that the majority of our triggered events are direct Cosmic Ray hits on the detector. No air shower candidate have been found in this analysis.
description: 7 Pages, 6 Figures. Presented in 36th International Cosmic Ray Conference (Madison, USA)
Anoctamin-4 is a bona fide Ca2+-dependent non-selective cation channel
Creators: name: Reichhart, Nadine
name: Schöberl, Simon
name: Keckeis, Susanne
name: Alfaar, Ahmad S.
name: Roubeix, Christophe
name: Cordes, Magdalena
name: Crespo-Garcia, Sergio
name: Haeckel, Akvile
name: Kociok, Norbert
name: Föckler, Renate
name: Fels, Gabriele
name: Mataruga, Anja
name: Rauh, Robert
name: Milenkovic, Vladimir M.
name: Zühlke, Kerstin
name: Klussmann, Enno
name: Schellenberger, Eyk
name: Strauß, Olaf
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: anoctamins
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Changes in cell function occur by specific patterns of intracellular Ca2+, activating Ca2+-sensitive proteins. The anoctamin (TMEM16) protein family has Ca2+-dependent ion channel activity, which provides transmembrane ion transport, and/or Ca2+-dependent phosphatidyl-scramblase activity. Using amino acid sequence analysis combined with measurements of ion channel function, we clarified the so far unknown Ano4 function as Ca2+-dependent, non-selective monovalent cation channel; heterologous Ano4 expression in HEK293 cells elicits Ca2+ activated conductance with weak selectivity of K+ > Na+ > Li+. Endogenously expressed Ca2+-dependent cation channels in the retinal pigment epithelium were identified as Ano4 by KO mouse-derived primary RPE cells and siRNA against Ano4. Exchanging a negatively charged amino acid in the putative pore region (AA702-855) into a positive one (E775K) turns Ano4-elicited currents into Cl- currents evidencing its importance for ion selectivity. The molecular identification of Ano4 as a Ca2+-activated cation channel advances the understanding of its role in Ca2+ signaling.
Modeling of the saturation current of a fission chamber taking into account the distorsion of electric field due to space charge effects
Creators: name: Poujade, Olivier
name: Lebrun, Alain
Publisher: name: arXiv
Year: 2002
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Fission chambers were first made fifty years ago for neutron detection. At the moment, the French Atomic Energy Commission \textsf{(CEA-Cadarache)} is developing a sub-miniature fission chamber technology with a diameter of 1.5 mm working in the current mode (Bign). To be able to measure intense fluxes, it is necessary to adjust the chamber geometry and the gas pressure before testing it under real neutron flux. In the present paper, we describe a theoretical method to foresee the current-voltage characteristics (sensitivity and saturation plateau) of a fission chamber whose geometrical features are given, taking into account the neutron flux to be measured (spectrum and intensity). The proposed theoretical model describes electric field distortion resulting from charge collection effect. A computer code has been developed on this model basis. Its application to 3 kinds of fission chambers indicates excellent agreement between theoretical model and measured characteristics.
Spin Pseudo Gap in La2-xSrxCuO4 Studied by Neutron Scattering
Creators: name: Lee, C. H.
name: Yamada, K.
name: Hiraka, H.
name: Rao, C. R. Venkateswara
name: Endoh, Y.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Spin excitations of La2-xSrxCuO have been studied using inelastic neutron scattering techniques in the energy range of 2 meV =< w =< 12 meV and the temperature range of 8 K =< T =< 150 K. We observed a signature of a spin pseudo gap in the excitation spectrum above Tc for the slightly overdoped sample with x = 0.18. On heating, the spin pseudo gap gradually collapses between T = 80 K and 150 K. For the x = 0.15 and 0.20, although the visibility of gap-like structure at T ~ Tc is lower compared to the x = 0.18 sample, the broad bump of kai"(w) appears at w ~ 5 meV,close to the spin-gap energy at base temperature, suggests the existence of the spin pseudo gap in the normal state.
description: revtex, 7 pages, 8 eps figures, PRB (2003) in press
Less Is More - Estimation of the Number of Strides Required to Assess Gait Variability in Spatially Confined Settings
Creators: name: Kroneberg, Daniel
name: Elshehabi, Morad
name: Meyer, Anne-Christiane
name: Otte, Karen
name: Doss, Sarah
name: Paul, Friedemann
name: Nussbaum, Susanne
name: Berg, Daniela
name: Kühn, Andrea A.
name: Maetzler, Walter
name: Schmitz-Hübsch, Tanja
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: gait variability
subject: gait analysis
subject: turn detection
subject: healthy elderly
subject: movement disorders
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Gait variability is an established marker of gait function that can be assessed using sensor-based approaches. In clinical settings, spatial constraints and patient condition impede the execution of longer distance walks for the recording of gait parameters. Turning paradigms are often used to overcome these constraints and commercial gait analysis systems algorithmically exclude turns for gait parameters calculations. We investigated the effect of turns in sensor-based assessment of gait variability. Methods: Continuous recordings from 31 patients with movement disorders (ataxia, essential tremor and Parkinson's disease) and 162 healthy elderly (HE) performing level walks including 180° turns were obtained using an inertial sensor system. Accuracy of the manufacturer's algorithm of turn-detection was verified by plotting stride time series. Strides before and after turn events were extracted and compared to respective average of all strides. Coefficient of variation (CoV) of stride length and stride time was calculated for entire set of strides, segments between turns and as cumulative values. Their variance and congruency was used to estimate the number of strides required to reliably assess the magnitude of stride variability. Results: Non-detection of turns in 5.8% of HE lead to falsely increased CoV for these individuals. Even after exclusion of these, strides before/after turns tended to be spatially shorter and temporally longer in all groups, contributing to an increase of CoV at group level and widening of confidence margins with increasing numbers of strides. This could be attenuated by a more generous turn excision as an alternative approach. Correlation analyses revealed excellent consistency for CoVs after at most 20 strides in all groups. Respective stride counts were even lower in patients using a more generous turn excision. Conclusion: Including turns to increase continuous walking distance in spatially confined settings does not necessarily improve the validity and reliability of gait variability measures. Specifically with gait pathology, perturbations of stride characteristics before/after algorithmically excised turns were observed that may increase gait variability with this paradigm. We conclude that shorter distance walks of around 15 strides suffice for reliable and valid recordings of gait variability in the groups studied here.
Fractional Dark Matter decay: cosmological imprints and observational constraints
Creators: name: Xiao, Linfeng
name: Zhang, Le
name: An, Rui
name: Feng, Chang
name: Wang, Bin
Publisher: name: arXiv
Year: 2019
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: If a fraction $f_{\rm dcdm}$ of the Dark Matter decays into invisible and massless particles (so-called "dark radiation") with the decay rate (or inverse lifetime) $Γ_{\rm dcdm}$, such decay will leave distinctive imprints on cosmological observables. With a full consideration of the Boltzmann hierarchy, we calculate the decay-induced impacts not only on the CMB but also on the redshift distortion and the kinetic Sunyaev-Zel'dovich effect, while providing detailed physical interpretations based on evaluating the evolution of gravitational potential. By using the current cosmological data with a combination of Planck 2015, Baryon Acoustic Oscillation and redshift distortion measurements which can improve the constraints, we update the $1σ$ bound on the fraction of decaying DM from $f_{\rm dcdm}\lesssim5.26\%$ to $f_{\rm dcdm}\lesssim2.73\%$ for the short-lived DM (assuming $Γ_{\rm dcdm}/H_0\gtrsim10^4$). However, no constraints are improved from RSD data ($f_{\rm dcdm}\lesssim0.94\%$) for the long-lived DM (i.e., $Γ_{\rm dcdm}/H_0\lesssim10^4$). We also find the fractional DM decay can only slightly reduce the $H_0$ and $σ_8$ tensions, which is consistent with other previous works. Furthermore, our calculations show that the kSZ effect in future would provide a further constraining power on the decaying DM.
description: 34 pages, 18 figures, 5 tables, accepted for publication in JCAP
Searching for the CP-Violation Associated with Majorana Neutrinos
Creators: name: Pascoli, S.
name: Petcov, S. T.
name: Wolfenstein, L.
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The effective Majorana mass which determines the rate of the neutrinoless double beta decay, ||, is considered in the case of three-neutrino mixing and massive Majorana neutrinos. Assuming a rather precise determination of the parameters characterizing the neutrino oscillation solutions of the solar and atmospheric neutrino problems has been made, we discuss the information a measurement of || > (0.005 - 0.010) eV can provide on the value of the lightest neutrino mass and on the CP-violation in the lepton sector. The implications of combining a measurement of || with future measurement of the neutrino mass in tritium beta-decay experiments for the possible determination of leptonic CP-violation are emphasized.
description: 15 pages, LATEX, 2 figures. Results unchanged; few clarifying remarks and one reference added. Version to be published in Phys. Lett. B
On infinitesimal generators of sublinear Markov semigroups
Creators: name: Kühn, Franziska
Publisher: name: arXiv
Year: 2019
Subjects: subject: Probability (math.PR)
subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 47H20, 60J35, 47J35, 49L25

description: We establish a Dynkin formula and a Courrège-von Waldenfels theorem for sublinear Markov semigroups. In particular, we show that any sublinear operator $A$ on $C_c^{\infty}(\mathbb{R}^d)$ satisfying the positive maximum principle can be represented as supremum of a family of pseudo-differential operators: $$Af(x) = \sup_{α\in I} (-q_α(x,D) f)(x).$$ As an immediate consequence, we obtain a representation formula for infinitesimal generators of sublinear Markov semigroups with a sufficiently rich domain. We give applications in the theory of non-linear Hamilton--Jacobi--Bellman equations and Lévy processes for sublinear expectations.
A new iron(II) complex as bi-functional electrocatalyst for hydrogen evolution reaction and hydrogen peroxide sensing
Creators: name: Wu, Qing
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified

description: In this paper, a new Fe(II) complex, [FeCl2(BBP)]·(IPA)2 (BBP = 1,3-bis(1H-benzimidazole-2-yl)propane, IPA = isopropanol), was synthesized and characterized by single crystal X-ray diffraction, elemental analysis, IR and UV/Vis spectroscopy. The crystal analysis showed that the Fe(II) complex is mononuclear, and its Fe(II) center is four coordinate in a slightly distorted tetrahedron. The electrocatalytic activity towards HER and the electrochemical sensing performance to H2O2 of the Fe(II) complex was investigated by fabricating a composite electrode (a carbon paste electrode doped with the Fe(II) complex, Fe-CPE for short). Electrochemical studies have shown that the Fe-CPE only required a low overpotential of −0.481 V to drive the current density of 10 mA cm−2 with a smaller Tafel slope of 0.142 V dec−1 for HER in 0.5 M H2SO4 at 298 K. Additionally, Fe-CPE serves as a H2O2 sensor with superior electrocatalytic activity and a low detection limit of 0.36 μM (S/N = 3) in a linear range from 5.0 × 10−7 to 4.0 × 10−3 M in 0.5 M NaOH at −0.7 V. The above studies prove that the Fe(II) complex can be used as an effective bi-functional molecular electrocatalyst for HER and H2O2 sensing.
Chi3l3 induces oligodendrogenesis in an experimental model of autoimmune neuroinflammation
Creators: name: Starossom, Sarah C.
name: Garcia, Juliana Campo
name: Woelfle, Tim
name: Romero-Suarez, Silvina
name: Olah, Marta
name: Watanabe, Fumihiro
name: Cao, Li
name: Yeste, Ada
name: Tukker, John J.
name: Quintana, Francisco J.
name: Imitola, Jaime
name: Witzel, Franziska
name: Schmitz, Dietmar
name: Morkel, Markus
name: Paul, Friedemann
name: Infante-Duarte, Carmen
name: Khoury, Samia J.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: multiple sclerosis
subject: oligodendrogenesis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: In demyelinating diseases including multiple sclerosis (MS), neural stem cells (NSCs) can replace damaged oligodendrocytes if the local microenvironment supports the required differentiation process. Although chitinase-like proteins (CLPs) form part of this microenvironment, their function in this differentiation process is unknown. Here, we demonstrate that murine Chitinase 3-like-3 (Chi3l3/Ym1), human Chi3L1 and Chit1 induce oligoden-drogenesis. In mice, Chi3l3 is highly expressed in the subventricular zone, a stem cell niche of the adult brain, and in inflammatory brain lesions during experimental autoimmune encephalomyelitis (EAE). We find that silencing Chi3l3 increases severity of EAE. We present evidence that in NSCs Chi3l3 activates the epidermal growth factor receptor (EGFR), thereby inducing Pyk2-and Erk1/2- dependent expression of a pro-oligodendrogenic transcription factor signature. Our results implicate CLP-EGFR-Pyk2-MEK-ERK as a key intrinsic pathway controlling oligodendrogenesis.
Toward an accurate strongly-coupled many-body theory within the equation of motion framework
Creators: name: Litvinova, Elena
name: Schuck, Peter
Publisher: name: arXiv
Year: 2019
Subjects: subject: Nuclear Theory (nucl-th)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Non-perturbative aspects of the quantum many-body problem are revisited, discussed and advanced in the equation of motion framework. We compare the approach to the two-fermion response function truncated on the two-body level by the cluster expansion of the dynamical interaction kernel to the approach known as time blocking approximation. Such a comparison leads to an extended many-body theory with non-perturbative treatment of high-order configurations. The present implementation of the advanced theory introduces a new class of solutions for the response functions, which include explicitly beyond-mean-field correlations between up to six fermions. The novel approach, which includes configurations with two quasiparticles coupled to two phonons (2q$\otimes$2phonon), is discussed in detail for the particle-hole nuclear response and applied to medium-mass nuclei. The proposed developments are implemented numerically on the basis of the relativistic effective meson-nucleon Lagrangian and compared to the models confined by two-fermion and four-fermion configurations, which are considered as state-of-the-art for the response theory in nuclear structure calculations. The results obtained for the dipole response of $^{42,48}$Ca and $^{68}$Ni nuclei in comparison to available experimental data show that the higher configurations are necessary for a successful description of both gross and fine details of the spectra in both high-energy and low-energy sectors.
description: Article: 28 pages, 19 figures
MOESM2 of Therapist perceptions of a rehabilitation research study in the intensive care unit: a trinational survey assessing barriers and facilitators to implementing the CYCLE pilot randomized clinical trial
Creators: name: Reid, Julie
name: McCaskell, Devin
name: Kho, Michelle
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: Additional file 2. CYCLE RCT Survey additional file 2. Electronic Supplement for Therapist Perceptions of ICU Rehab Research. This additional file contains a copy of the electronic survey.
Entanglement of individual photon and atomic ensembles
Creators: name: Guo, Guo-Ping
name: Guo, Guang-Can
Publisher: name: arXiv
Year: 2002
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Here we present an experimentally feasible scheme to entangle flying qubit (individual photon with polarization modes) and stationary qubit (atomic ensembles with long-lived collective excitations). This entanglement integrate two different species can act as a critical element for the coherent transform of quantum information between flying and stationary qubits. The entanglement degree can be also adjusted expediently with linear optics. Furthermore, the present scheme can be modified to generate this entanglement in a way event-ready with the employment of a pair of entangled photons. Then successful preparation can be unambiguously heralded by coincident between two single-photon detectors. Its application for individal photons quantum memory is also analyzed. The physical requirements of all those preparation and applications processing are moderate, and well fit the present technique.
Doctors on the move: a qualitative study on the driving factors in a group of Egyptian physicians migrating to Germany
Creators: name: Schumann, Marwa
name: Maaz, Asja
name: Peters, Harm
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: Medical migration
subject: Egyptian physicians
subject: Germany
subject: Driving forces
subject: Push and pull factors
subject: Facilitators and barriers
subject: Licensing and registration of foreign physicians
subject: Qualitative study
subject: Social networks
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Migration of physicians has become a global phenomenon with significant implications for the healthcare delivery systems worldwide. The motivations and factors driving physician's migration are complex and continuously evolving. Purpose of this study is to explore the driving forces in a group of Egyptian physicians and final-years medical students preparing to migrate to Germany. Methods: A qualitative study was conducted based on social constructivism epistemology. In five focus group discussions, there participated a total 12 residents and 6 final-year medical students from 7 different training and workplace locations in Egypt. The participants provided information about their motivation and planning for migration. We applied a coding framework based on the concept of push/pull factors and barriers/facilitators for migration, and used Atlas.ti software for analysis. Results: The thematic analysis indicated that the migration within the study's participants results from a specific weighting of push and pull factors. Push factors are considered to be more important than pull factors. Factors related to professional development play a leading role. The route of migration towards Germany is mainly determined by the low hurdle registration and licensing requirements in this destination country compared to other countries. In some cases, Germany is regarded as a "transit country", a step on the road to other European countries. The intent, planning and preparation of migration is assisted considerably by the local formation of a community and culture of migration with multiple ways for information exchange, identity building and social support through face-to-face and online channels. Conclusions: This study specifies - in a group of Egyptian physicians and final-year medical students - the perceived push and pull factors which influenced their intent to migrate to Germany. In addition to the general wealth gap, their particular route of migration is mainly determined by the requirements in licensing and registration procedures for foreign physicians in the potential destination country. The planning and preparation of a move is substantially facilitated by their joining a social network and a community of migrating physicians.
New Type of String Solutions with Long Range Forces
Creators: name: Hiramatsu, Takashi
name: Ibe, Masahiro
name: Suzuki, Motoo
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We explore the formation and the evolution of the string network in the Abelian Higgs model with two complex scalar fields. A special feature of the model is that it possesses a global $U(1)$ symmetry in addition to the $U(1)$ gauge symmetry. Both symmetries are spontaneously broken by the vacuum expectation values of the two complex scalar fields. As we will show the dynamics of the string network is quite rich compared with that in the ordinary Abelian Higgs model with a single complex scalar field. In particular, we find a new type of string solutions in addition to the conventional Abrikosov-Nielsen-Olesen (local) string solution. We call this the uncompensated string. An isolated uncompensated string has a logarithmic divergent string tension as in the case of the global strings, although it is accompanied by a non-trivial gauge field configuration. We also perform classical lattice simulations in the $2+1$ dimensional spacetime, which confirms the formation of the uncompensated strings at the phase transition. We also find that most of the uncompensated strings evolve into the local strings at later time when the gauge charge of the scalar field with a smaller vacuum expectation value is larger than that of the scalar field with a larger vacuum expectation value.
description: 27 pages, 7 figures, 1 table
MOESM1 of Therapist perceptions of a rehabilitation research study in the intensive care unit: a trinational survey assessing barriers and facilitators to implementing the CYCLE pilot randomized clinical trial
Creators: name: Reid, Julie
name: McCaskell, Devin
name: Kho, Michelle
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Additional file 1: CYCLE RCT Survey additional file 1. Electronic Supplement for Therapist Perceptions of ICU Rehab Research. This additional file contains the following: Additional survey methods. Table S1. Table of specifications. Table S2. Details of survey testing. Table S3. Summary statistics for items in the Rehabilitation Practice and Research section. Table S4. Summary statistics for items in the Cycling section. Table S5. Respondent perceptions regarding primary responsibility for implementing cycling. Table S6. Summary statistics for items in the Outcome Measures section. Clinical sensibility testing tool. Reference.
MOESM2 of A comprehensive analysis of drug resistance molecular markers and Plasmodium falciparum genetic diversity in two malaria endemic sites in Mali
Creators: name: Seidina Diakité
name: Traoré, Karim
name: Sanogo, Ibrahim
name: Taane Clark
name: Campino, Susana
name: Modibo Sangaré
name: Djeneba Dabitao
name: Dara, Antoine
name: Drissa Konaté
name: Fousseyni Doucouré
name: Amadou Cissé
name: Bourama Keita
name: Mory Doumbouya
name: Merepen Guindo
name: Mahamoudou Toure
name: Nafomon Sogoba
name: Seydou Doumbia
name: Awandare, Gordon
name: Mahamadou Diakité
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Additional file 2: Codon substitutions in drug resistance genes.
Immune Mediator Profile in Aqueous Humor Differs in Patients with Primary Acquired Ocular Toxoplasmosis and Recurrent Acute Ocular Toxoplasmosis
Creators: name: Thieme, Claudia
name: Schlickeiser, Stephan
name: Metzner, Sylvia
name: Dames, Claudia
name: Pleyer, Uwe
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: primary acquired ocular toxoplasmosis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Purpose. To compare the intraocular cytokine and chemokine profiles in patients with acute primary acquired ocular toxoplasmosis (pOT) or recurrent ocular toxoplasmosis (rOT) and to correlate them with their clinical characteristics. Methods. Aqueous humor samples were collected from 62 consecutive patients (21 pOT, 30 rOT, and 11 noninfected controls) and analyzed by multiplex assay. Correlations were assessed between cytokine/chemokine levels, type of inflammatory response (T(h)1, T(h)2, and T(h)17), and clinical characteristics. In all OT patients, the clinical diagnosis of either pOT or rOT was confirmed by positive intraocular Goldmann/Witmer-Desmonts coefficient. Correlations were assessed between a preselected panel of immune mediators and the clinical characteristics of OT. Results. In pOT patients, increased levels of IL-2, IFN-γ, TNF-α, IL-15, IL-4, IL-5, IL-9, IL-13, IL-17, IL-1Rα, IL-6, IL-1β, and chemokines MIP-1α, MIP-1β, IP-10, Eotaxin, IL-8, RANTES, PDGF-bb, GM-CSF, G-CSF, and MCP-1 were found in comparison to those in controls (p<0.05). Patients with rOT showed elevated levels of IL-2, IFN-γ, TNF-α, IL-15, IL-4, IL-5, IL-9, IL-13, IL-17, IL-1Rα, IL-6, IL-1β, and chemokines MIP-1α, IP-10, Eotaxin, IL-8, RANTES, PDGF-bb, G-CSF, and MCP-1 compared to controls (p<0.05). In addition, IL-7 (p=0.028) differed between pOT and rOT; IL-9 (p=0.054) and IL-13 (p=0.051) showed a tendency of higher concentration in pOT than in rOT. A negative correlation was found between IL-7 (p=0.017) as well as IL-9 (p=0.008) and the number of recurrences. Cytokine ratios showed no difference between pOT and rOT, indicating a dominant T(h)1-type response in both infectious groups. Moreover, a positive correlation was detected between IL-7, VEGF, IL-13 and age at aqueous humor sampling (p<0.05). Conclusions. This study for the first time shows subtle differences between the intraocular cytokine profiles in patients with either acute pOT or rOT.
Status Report on the Light Baryonic States
Creators: name: Nefkens, B. M. K.
name: Price, J. W.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The regularities in the spectrum of the light baryon resonances are reviewed and compared with those of the light mesons. We discuss the occurrence of parity doublets and clusters, and note the trends in the values of the masses, widths, spins, and parities. The importance of SU(3) flavor is illustrated and the status of quark model calculations of the baryonic spectrum is reviewed. The absence of evidence for baryonic hybrids is particularly interesting. We propose to use better symbols for the baryon resonances which do not conflict with the simple quark structure of QCD. We shall comment also on fine tuning the Star System for the hadronic states. The importance of greater support for the construction and operation of secondary beams of $π$, $K$, $\bar p$, $\vec{n}$ and $\vecγ$ up to 5 GeV/$c$ for the future of non-perturbative QCD is emphasized.
description: 10 pages, 6 figures, talk given at the 9th International Symposium on Meson - Nucleon Physics and the Structure of the Nucleon (MENU 2001), Washington, District of Columbia, 26-31 Jul 2001. To be published in pi-N Newsletter 16 (2001)
Examining Adverse Selection in Organic Crop Insurance: Where Do We Go From Here?
Creators: name: Glenn, Viola
name: Dale, Kelli
name: Sligh, Michael
name: Robinson, James
name: Glenn, Viola
name: Dale, Kelli
name: Sligh, Michael
name: Robinson, James
Publisher: name: Unknown
Year: 2014
Subjects: Farm Management
Risk and Uncertainty

description: Understanding when and why organic farmers use crop insurance can not only instruct the design of an equitable and financially sustainable crop insurance system but also identify production methods that decrease dependence on program-based risk management. In this article, the research team will identify factors influencing organic farmers’ decision to purchase or forgo crop insurance. Do organic farmers opt out of crop insurance because it is not cost-effective, because alternative risk management tools are preferred, due to barriers to access, or for some other reason? Understanding the drivers of and barriers to crop insurance use by organic producers can inform crop insurance designs that meet producer needs as well as illustrate alternative risk management methods that should not be lost as a result of the crop insurance safety net.
Mapping class group and global Torelli theorem for hyperkahler manifolds: an erratum
Creators: name: Verbitsky, Misha
Publisher: name: arXiv
Year: 2019
Subjects: subject: Algebraic Geometry (math.AG)
subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics

description: A mapping class group of an oriented manifold is a quotient of its diffeomorphism group by the isotopies. In the published version of "Mapping class group and a global Torelli theorem for hyperkahler manifolds" I made an error based on a wrong quotation of Dennis Sullivan's famous paper "Infinitesimal computations in topology". I claimed that the natural homomorphism from the mapping class group to the group of automorphims of cohomology of a simply connected Kahler manifold has finite kernel. In a recent preprint arXiv:1907.05693, Matthias Kreck and Yang Su produced counterexamples to this statement. Here I correct this error and other related errors, observing that the results of "Mapping class group and a global Torelli theorem" remain true after an appropriate change of terminology.
description: 9 pages, version 2.1, small improvements throughout, minor errors squashed
Quantum Chaos at Finite Temperature
Creators: name: Caron, L. A.
name: Jirari, H.
name: Kröger, H.
name: Luo, X. Q.
name: Melkonyan, G.
name: Moriarty, K. J. M.
Publisher: name: arXiv
Year: 2001
Subjects: subject: Quantum Physics (quant-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We use the quantum action to study quantum chaos at finite temperature. We present a numerical study of a classically chaotic 2-D Hamiltonian system - harmonic oscillators with anharmonic coupling. We construct the quantum action non-perturbatively and find temperature dependent quantum corrections in the action parameters. We compare Poincaré sections of the quantum action at finite temperature with those of the classical action.
description: Text (LaTeX), Figs. (ps)
MOESM4 of Influence of oxytocin receptor single nucleotide sequence variants on contractility of human myometrium: an in vitro functional study
Creators: name: F. Füeg
name: S. Santos
name: C. Haslinger
name: B. Stoiber
name: L. Schäffer
name: E. Grünblatt
name: R. Zimmermann
name: A. Simões-Wüst
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology

description: Additional file 4: Table S4. OXTR-mRNA in the various reference and variant allele groups.
Dose-Dependent Effect of Mesenchymal Stromal Cell Recruiting Chemokine CCL25 on Porcine Tissue-Engineered Healthy and Osteoarthritic Cartilage
Creators: name: Lüderitz, Luise
name: Dehne, Tilo
name: Sittinger, Michael
name: Ringe, Jochen
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: CCL25
subject: Thymus-expressed chemokine
subject: cartilage
subject: in vitro osteoarthritis model
subject: in situ tissue engineering
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Thymus-expressed chemokine (CCL25) is a potent cell attractant for mesenchymal stromal cells, and therefore it is a candidate for in situ cartilage repair approaches focusing on the recruitment of endogenous repair cells. However, the influence of CCL25 on cartilage is unknown. Accordingly, in this study, we investigated the effect of CCL25 on tissue-engineered healthy and osteoarthritic cartilage. Porcine chondrocytes were cultured in a three-dimensional (3D) micromass model that has been proven to mimic key-aspects of human cartilage and osteoarthritic alterations upon stimulation with tumor necrosis factor-α (TNF-α). Micromass cultures were stimulated with CCL25 (0, 0.05, 0.5, 5, 50, 500 nmol/L) alone or in combination with 0.6 nmol/L TNF-α for seven days. Effects were evaluated by life/dead staining, safranin O staining, histomorphometrical analysis of glycosaminoglycans (GAGs), collagen type II (COL2A1) real-time RT-PCR and Porcine Genome Array analysis. 500 nmol/L CCL25 led to a significant reduction of GAGs and COL2A1 expression and induced the expression of matrix metallopeptidases (MMP) 1, MMP3, early growth response protein 1 (EGR1), and superoxide dismutase 2 (SOD2). In concentrations lower than 500 nmol/L, CCL25 seems to be a candidate for in situ cartilage repair therapy approaches.
Sex-specific regulation of cardiac microRNAs targeting mitochondrial proteins in pressure overload
Creators: name: Sanchez-Ruderisch, Hugo
name: Queirós, Ana Maria
name: Fliegner, Daniela
name: Eschen, Claudia
name: Kararigas, Georgios
name: Regitz-Zagrosek, Vera
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: Cardiac
subject: ERβ
subject: microRNA
subject: Mitochondrial
subject: Pressure overload
subject: Sex differences
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Maladaptive remodeling in pressure overload (PO)-induced left ventricular hypertrophy (LVH) may lead to heart failure. Major sex differences have been reported in this process. The steroid hormone 17β-estradiol, along with its receptors ERα and ERβ, is thought to be crucial for sex differences and is expected to be protective, but this may not hold true for males. Increasing evidence demonstrates a major role for microRNAs (miRNAs) in PO-induced LVH. However, little is known about the effects of biological sex and ERβ on cardiac miRNA regulation and downstream mitochondrial targets. We aimed at the analysis of proteins involved in mitochondrial metabolism testing the hypothesis that they are the target of sex-specific miRNA regulation. Methods: We employed the transverse aortic constriction model in mice and assessed the levels of five mitochondrial proteins, i.e., Auh, Crat, Decr1, Hadha, and Ndufs4. Results: We found a significant decrease of the mitochondrial proteins primarily in the male overloaded heart compared with the corresponding control group. Following computational analysis to identify miRNAs putatively targeting these proteins, our in vitro experiments employing miRNA mimics demonstrated the presence of functional target sites for miRNAs in the 3'-untranslated region of the messenger RNAs coding for these proteins. Next, we assessed the levels of the functionally validated miRNAs under PO and found that their expression was induced only in the male overloaded heart. In contrast, there was no significant effect on miRNA expression in male mice with deficient ERβ. Conclusion: We put forward that the male-specific induction of miRNAs and corresponding downregulation of downstream protein targets involved in mitochondrial metabolism may contribute to sex-specific remodeling in PO-induced LVH.
MOESM1 of A comprehensive analysis of drug resistance molecular markers and Plasmodium falciparum genetic diversity in two malaria endemic sites in Mali
Creators: name: Seidina Diakité
name: Traoré, Karim
name: Sanogo, Ibrahim
name: Taane Clark
name: Campino, Susana
name: Modibo Sangaré
name: Djeneba Dabitao
name: Dara, Antoine
name: Drissa Konaté
name: Fousseyni Doucouré
name: Amadou Cissé
name: Bourama Keita
name: Mory Doumbouya
name: Merepen Guindo
name: Mahamoudou Toure
name: Nafomon Sogoba
name: Seydou Doumbia
name: Awandare, Gordon
name: Mahamadou Diakité
Publisher: name: figshare
Year: 2019
Subjects: Medicine
Pharmacology
Computational Biology

description: Additional file 1: Table S1. Baseline characteristics of the participants. Table S2. Clinical characteristics of participants.
Growth of superconducting MgB2 thin films via postannealing techniques
Creators: name: Kang, W. N.
name: Choi, Eun-Mi
name: Kim, Hyeong-Jin
name: Kim, Hyun-Jung
name: Lee, Sung-Ik
Publisher: name: arXiv
Year: 2002
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We report the effect of annealing on the superconductivity of MgB2 thin films as functions of the postannealing temperature in the range from 700 C to 950 C and of the postannealing time in the range from 30 min to 120 min. On annealing at 900 C for 30 min, we obtained the best-quality MgB2 films with a transition temperature of 39 K and a critical current density of ~ 10^7 A/cm^2. Using the scanning electron microscopy, we also investigated the film growth mechanism. The samples annealed at higher temperatures showed the larger grain sizes, well-aligned crystal structures with preferential orientations along the c-axis, and smooth surface morphologies. However, a longer annealing time prevented the alignment of grains and reduced the superconductivity, indicating a strong interfacial reaction between the substrate and the MgB2 film.
description: 7 pages, 4 figures included
Tibio-femoral contact force distribution is not the only factor governing pivot location after total knee arthroplasty
Creators: name: Trepczynski, Adam
name: Kutzner, Ines
name: Schütz, Pascal
name: Dymke, Jörn
name: List, Renate
name: Roth, Philipp Von
name: Moewis, Philippe
name: Bergmann, Georg
name: Taylor, William R.
name: Duda, Georg N.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: total knee arthroplasty
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Total knee arthroplasty aims to mimic the natural knee kinematics by optimizing implant geometry, but it is not clear how loading relates to tibio-femoral anterior-posterior translation or internal-external pivoting. We hypothesised that the point of pivot in the transverse plane is governed by the location of the highest axial force. Tibio-femoral loading was measured using an instrumented tibial component in six total knee arthroplasty patients (aged 65-80y, 5-7y post-op) during 5-6 squat repetitions, while knee kinematics were captured using a mobile video-fluoroscope. In the range of congruent tibio-femoral contact the medial femoral condyle remained approximately static while the lateral condyle translated posteriorly by 4.1 mm (median). Beyond the congruent range, the medial and lateral condyle motions both abruptly changed to anterior sliding by 4.6 mm, and 2.6 mm respectively. On average, both the axial loading and pivot position were more medial near extension, and transferred to the lateral side in flexion. However, no consistent relationship between pivoting and load distribution was found across all patients throughout flexion, with R-2 values ranging from 0.00 to 0.65. Tibio-femoral kinematics is not related to the load distribution alone: medial loading of the knee does not necessarily imply a medial pivot location.
Anabolic Therapies in Osteoporosis and Bone Regeneration
Creators: name: Russow, Gabriele
name: Jahn, Denise
name: Appelt, Jessika
name: Märdian, Sven
name: Tsitsilonis, Serafeim
name: Keller, Johannes
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: osteoporosis
subject: anabolic therapy
subject: bone regeneration
subject: parathyroid hormone
subject: sclerostin
subject: romosozumab
subject: denosumab
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Osteoporosis represents the most common bone disease worldwide and results in a significantly increased fracture risk. Extrinsic and intrinsic factors implicated in the development of osteoporosis are also associated with delayed fracture healing and impaired bone regeneration. Based on a steadily increasing life expectancy in modern societies, the global implications of osteoporosis and impaired bone healing are substantial. Research in the last decades has revealed several molecular pathways that stimulate bone formation and could be targeted to treat both osteoporosis and impaired fracture healing. The identification and development of therapeutic approaches modulating bone formation, rather than bone resorption, fulfils an essential clinical need, as treatment options for reversing bone loss and promoting bone regeneration are limited. This review focuses on currently available and future approaches that may have the potential to achieve these aims.
Bremsstrahlung Radiation as Coherent State in Thermal QED
Creators: name: Wang, Enke
name: Xiao, Jun
name: Zhang, Hanzhong
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Based on fully finite temperature field theory we investigate the radiation probability in the bremsstrahlung process in thermal QED. It turns out that the infrared divergences resulting from the emission and absorption of the real photons are canceled by the virtual photon exchange processes at finite temperature. The full quantum calculation results for soft photons radiation coincide completely with that obtained in the semi-classical approximation. In the framework of Thermofield Dynamics it is shown that the bremsstrahlung radiation in thermal QED is a coherent state, the quasiclassical behavior of the coherent state leads to above coincidence.
description: 8 pages, 2 figures
On the Lipophilic Nature of Autoreactive IgE in Chronic Spontaneous Urticaria
Creators: name: Lakin, Elisa
name: Church, Martin K.
name: Maurer, Marcus
name: Schmetzer, Oliver
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: chronic spontaneous urticaria
subject: IgE
subject: autoreactivity
subject: lipophilicity
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Chronic spontaneous urticaria (CSU) is a skin disease related to autoreactive IgE in at least a subgroup of patients. However, the nature of this autoreactive IgE remains poorly characterized. This investigation had three objectives: first, to quantity CSU autoreactive IgE; second, to recognize the patterns of CSU autoreactive IgE compared with healthy control IgE; and third, to investigate the physiochemical nature of CSU autoreactive IgE. Methods: IgE autoreactivity was assessed in sera from 7 CSU and 7 healthy individuals. Autoantigen recognition patterns were assessed using principal component analysis (PCA) and heatmap visualization. Lipophilicity was assessed using NanoOrange reagent. Results: First, although total IgE levels did not differ significantly, the autoreactive proportion of IgE of CSU patients was 62% +/- 37%, 1000-fold higher than that of healthy controls 0.03% +/- 0.008% (P = 0.0006). Second, CSU autoreactive IgE differed from healthy control IgE by recognizing more and different autoantigens (226 vs. 34; P = 0.01). Third, the median (with 10-90% percentiles) serum level of lipophilic IgE was 39% (38-40%) in 232 CSU patients, 1.4-fold higher than the 28% (26-29%) of 173 healthy controls (P < 0.0001). Furthermore, lipophilicity correlated with autoreactivity (r = 0.8; P < 0.0001), connecting these two observed features. Conclusion: We believe that these novel observations about CSU autoreactive IgE, particularly the finding that it is more lipophilic than that of IgE from healthy individuals, will lead to the development of new diagnostic tests and therapies for autoreactive IgE-mediated diseases.