cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
CCR5 Haplotypes and Mother-to-Child HIV Transmission in Malawi
Creators: name: Kamwendo, Deborah
name: Meshnick, Steven R.
name: Mwapasa, Victor
name: Molyneux, Malcolm
name: Blood, Melinda
name: North, Kari
name: Pedersen, Bonnie R.
name: Rogerson, Stephen J.
name: Zimmerman, Peter
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: BackgroundCCR5 and CCR2 gene polymorphisms (SNPs) have been associated with protection against HIV transmission in adults and with delayed progression to AIDS. The CCR5 Δ32 deletion and SNP -2459G are associated with reduced expression of the CCR5 protein.Methodology/Principal FindingsWe investigated the association between infant CCR2/CCR5 diplotype and HIV mother to child transmission (MTCT) in Malawi. Blood samples from infants (n = 552) of HIV positive women who received nevirapine were genotyped using a post-PCR multiplex ligase detection reaction and haplotypes were identified based on 8 CCR2/CCR5 SNPs and the open reading frame 32 base pair deletion. Following verification of Hardy-Weinberg equilibrium, log linear regression was performed to examine the association between mutations and MTCT. Overall, protection against MTCT was weakly associated with two CCR5 SNPs, -2459G (Risk ratio [RR], 0.78; confidence interval [CI], 0.54–1.12), and the linked CCR5 -2135T (RR, 0.78; CI, 0.54–1.13). No child carried the CCR5 Δ32 SNP. Maternal Viral Load (MVL) was found to be an effect measure modifier. Among mothers with low MVL, statistically significant protection against MTCT was observed for -2459G (RR, 0.50; CI, 0.27–0.91), and -2135T (RR, 0.51; CI, 0.28–0.92). Statistically significant protection was not found at high MVL.Conclusions/SignificanceResults from this study suggest that CCR5 SNPs -2459G and -2135T associated with reduced receptor expression protect against MTCT of HIV at low MVLs, whereas high MVLs may over-ride differences in coreceptor availability.
Functional COMT Val158Met Polymorphism, Risk of Acute Coronary Events and Serum Homocysteine: The Kuopio Ischaemic Heart Disease Risk Factor Study
Creators: name: Kaplan, George A.
name: Mursu, Jaakko
name: Erlund, Iris
name: Tuomainen, Tomi-Pekka
name: Salonen, Jukka T.
name: Mosher, M.J.
name: Kauhanen, Jussi
name: Virtanen, Jyrki K.
name: Voutilainen, Sari
name: Alfthan, Georg
name: Happonen, Pertti
name: Tiihonen, Jari
name: Korhonen, Maarit
name: North, Kari E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: BackgroundThe role of circulating levels of total homocysteine tHcy in the development of coronary heart disease (CHD) is still under debate. One reason for conflicting results between previous studies on homocysteine and heart diseases could be consequence of different interactions between homocysteine and genes in different study populations. Many genetic factors play a role in folate-homocysteine metabolism, like functional polymorphism (Val108Met) in the Catechol-O-methyltransferase (COMT) gene.Methodology and FindingsOur aim was to examine the role of COMT Val158Met polymorphism and interaction of this polymorphism with serum tHcy and folate concentration on the risk of acute coronary and events in middle-aged men from eastern Finland. A population-based prospective cohort of 792 men aged 46–64 years was examined as part of the Kuopio Ischaemic Heart Disease Risk Factor Study. During an average follow-up of 9.3 years, there were 69 acute coronary events in men with no previous history of CHD. When comparing the COMT low activity genotype with the others, we found an age and examination year adjusted hazard rate ratio (HRR) of 1.73 (95% confidence interval (CI), 1.07–2.79), and an age, examination year, serum LDL and HDL cholesterol, and triglyceride concentration, systolic blood pressure and smoking adjusted HRR of 1.77 (95% CI, 1.05–2.77). Although serum tHcy concentration was not statistically significantly associated with acute coronary events (HRR for the highest third versus others 1.52, 95% CI, 0.93–2.49), subjects with both high serum tHcy and the COMT low activity genotype had an additionally increased adjusted risk of HRR 2.94 (95% CI 1.50–5.76) as compared with other men.ConclusionsThis prospective cohort study suggests that the functional COMT Val158Met polymorphism is associated with increased risk of acute coronary events and it may interact with high serum tHcy levels.
Gallup Canada Poll # 1999-10: Charity/Gun Control
Creators: name: Gallup Canada, Inc.
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Federal election (2); Jean Chretien job performance (1); volunteer activities (5); charitable donations (1); reasons to save money (3); Halloween (3); laws regarding firearms (2); gun ownership (2); requirements for gun ownership (5).
High-Throughput Sequencing of Arabidopsis microRNAs: Evidence for Frequent Birth and Death of MIRNA Genes
Creators: name: Kasschau, Kristin D.
name: Dangl, Jeffery L.
name: Sullivan, Christopher M.
name: Fahlgren, Noah
name: Law, Theresa F.
name: Cumbie, Jason S.
name: Givan, Scott A.
name: Carrington, James C.
name: Chapman, Elisabeth J.
name: Grant, Sarah R.
name: Howell, Miya D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: In plants, microRNAs (miRNAs) comprise one of two classes of small RNAs that function primarily as negative regulators at the posttranscriptional level. Several MIRNA genes in the plant kingdom are ancient, with conservation extending between angiosperms and the mosses, whereas many others are more recently evolved. Here, we use deep sequencing and computational methods to identify, profile and analyze non-conserved MIRNA genes in Arabidopsis thaliana. 48 non-conserved MIRNA families, nearly all of which were represented by single genes, were identified. Sequence similarity analyses of miRNA precursor foldback arms revealed evidence for recent evolutionary origin of 16 MIRNA loci through inverted duplication events from protein-coding gene sequences. Interestingly, these recently evolved MIRNA genes have taken distinct paths. Whereas some non-conserved miRNAs interact with and regulate target transcripts from gene families that donated parental sequences, others have drifted to the point of non-interaction with parental gene family transcripts. Some young MIRNA loci clearly originated from one gene family but form miRNAs that target transcripts in another family. We suggest that MIRNA genes are undergoing relatively frequent birth and death, with only a subset being stabilized by integration into regulatory networks.
Potent Activity of the HIV-1 Maturation Inhibitor Bevirimat in SCID-hu Thy/Liv Mice
Creators: name: Smith, Philip C.
name: Bare, Jennifer C.
name: Wild, Carl T.
name: Sloan, Barbara
name: Martin, David E.
name: Allaway, Graham P.
name: Joshi, Pheroze
name: Stoddart, Cheryl A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: BackgroundThe HIV-1 maturation inhibitor, 3-O-(3′,3′-dimethylsuccinyl) betulinic acid (bevirimat, PA-457) is a promising drug candidate with 10 nM in vitro antiviral activity against multiple wild-type (WT) and drug-resistant HIV-1 isolates. Bevirimat has a novel mechanism of action, specifically inhibiting cleavage of spacer peptide 1 (SP1) from the C-terminus of capsid which results in defective core condensation.Methods and FindingsOral administration of bevirimat to HIV-1-infected SCID-hu Thy/Liv mice reduced viral RNA by >2 log10 and protected immature and mature T cells from virus-mediated depletion. This activity was observed at plasma concentrations that are achievable in humans after oral dosing, and bevirimat was active up to 3 days after inoculation with both WT HIV-1 and an AZT-resistant HIV-1 clinical isolate. Consistent with its mechanism of action, bevirimat caused a dose-dependent inhibition of capsid-SP1 cleavage in HIV-1-infected human thymocytes obtained from these mice. HIV-1 NL4-3 with an alanine-to-valine substitution at the N-terminus of SP1 (SP1/A1V), which is resistant to bevirimat in vitro, was also resistant to bevirimat treatment in the mice, and SP1/AIV had replication and thymocyte kinetics similar to that of WT NL4-3 with no evidence of fitness impairment in in vivo competition assays. Interestingly, protease inhibitor-resistant HIV-1 with impaired capsid-SP1 cleavage was hypersensitive to bevirimat in vitro with a 50% inhibitory concentration 140 times lower than for WT HIV-1.ConclusionsThese results support further clinical development of this first-in-class maturation inhibitor and confirm the usefulness of the SCID-hu Thy/Liv model for evaluation of in vivo antiretroviral efficacy, drug resistance, and viral fitness.
Smooth bimodules and cohomology of II$_1$ factors
Creators: name: Galatan, Alin
name: Popa, Sorin
Publisher: name: arXiv
Year: 2014
Subjects: subject: Operator Algebras (math.OA)
subject: FOS: Mathematics

description: We prove that, under rather general conditions, the 1-cohomology of a von Neumann algebra $M$ with values in a Banach $M$-bimodule satisfying a combination of smoothness and operatorial conditions, vanishes. For instance, we show that if $M$ acts normally on a Hilbert space $\Cal H$ and $\Cal B_0\subset \Cal B(\Cal H)$ is a norm closed $M$-bimodule such that any $T\in \Cal B_0$ is {\it smooth} (i.e. the left and right multiplication of $T$ by $x\in M$ are continuous from the unit ball of $M$ with the $s^*$-topology to $\Cal B_0$ with its norm), then any derivation of $M$ into $\Cal B_0$ is inner. The compact operators are smooth over any $M\subset \Cal B(\Cal H)$, but there is a large variety of non-compact smooth elements as well.
description: 36 pages
Gallup Poll # 1999-12
Creators: name: Gallup Canada, Inc.
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Federal election(2) Chretion job performance(1) year 2000 economy(1) unemployment 2000(1) Quebec secession(3) items purchase(3) country's economy(2) household financial situation(1) major purchases(1) living standard(2) Christmas(11) 2000 new year's eve(2) Y2K bug(10) human race getting better or worse(4) events in the next 50 years(3) most influential nation by 2050(1)
An Integrable Deformation of the AdS5 x S5 Superstring
Creators: name: Hollowood, Timothy J.
name: Miramontes, J. Luis
name: Schmidtt, David M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The S-matrix on the world-sheet theory of the string in AdS5 x S5 has previously been shown to admit a deformation where the symmetry algebra is replaced by the associated quantum group. The case where q is real has been identified as a particular deformation of the Green-Schwarz sigma model. An interpretation of the case with q a root of unity has, until now, been lacking. We show that the Green-Schwarz sigma model admits a discrete deformation which can be viewed as a rather simple deformation of the F/F_V gauged WZW model, where F=PSU(2,2|4). The deformation parameter q is then a k-th root of unity where k is the level. The deformed theory has the same equations-of-motion as the Green-Schwarz sigma model but has a different symplectic structure. We show that the resulting theory is integrable and has just the right amount of kappa-symmetries that appear as a remnant of the fermionic part of the original gauge symmetry. This points to the existence of a fully consistent deformed string background.
description: 23 pages, improved and expanded discussion of metric and B field
Radial Glial Dependent and Independent Dynamics of Interneuronal Migration in the Developing Cerebral Cortex
Creators: name: Watson, Hannah
name: Ghashghaei, H. T.
name: Anton, E.S.
name: Han, Christine
name: Yokota, Yukako
name: Campbell, Kenneth J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Interneurons originating from the ganglionic eminence migrate tangentially into the developing cerebral wall as they navigate to their distinct positions in the cerebral cortex. Compromised connectivity and differentiation of interneurons are thought to be an underlying cause in the emergence of neurodevelopmental disorders such as schizophrenia. Previously, it was suggested that tangential migration of interneurons occurs in a radial glia independent manner. Here, using simultaneous imaging of genetically defined populations of interneurons and radial glia, we demonstrate that dynamic interactions with radial glia can potentially influence the trajectory of interneuronal migration and thus the positioning of interneurons in cerebral cortex. Furthermore, there is extensive local interneuronal migration in tangential direction opposite to that of pallial orientation (i.e., in a medial to lateral direction from cortex to ganglionic eminence) all across the cerebral wall. This counter migration of interneurons may be essential to locally position interneurons once they invade the developing cerebral wall from the ganglionic eminence. Together, these observations suggest that interactions with radial glial scaffold and localized migration within the expanding cerebral wall may play essential roles in the guidance and placement of interneurons in the developing cerebral cortex.
Regional Decline of Coral Cover in the Indo-Pacific: Timing, Extent, and Subregional Comparisons
Creators: name: Selig, Elizabeth R.
name: Bruno, John F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: A number of factors have recently caused mass coral mortality events in all of the world's tropical oceans. However, little is known about the timing, rate or spatial variability of the loss of reef-building corals, especially in the Indo-Pacific, which contains 75% of the world's coral reefs.
Single and multiple doping effects on electron transport in zigzag silicene nanoribbons
Creators: name: Chen, J.
name: Wang, X. F.
name: Vasilopoulos, P.
name: Chen, A. B.
name: Wu, J. C.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: A nonequilibrium Green's function technique combined with density functional theory is used to study the spin-dependent electronic band structure and transport properties of zigzag silicene nanoribbons (ZSiNRs) doped with aluminum (Al) or phosphorus (P) atoms. The presence of a single Al or P atom induces quasibound states in ZSiNRs that can be observed as new dips in the electron conductance. The Al atom acts as an acceptor whereas the P atom acts as a donor when it is placed at the center of the ribbon. This behavior is reversed when the dopant is placed on the edges. Accordingly, an acceptor-donor transition is observed in ZSiNRs upon changing the dopant's position. Similar results are obtained when two silicon atoms are replaced by two impurities (Al or P atoms) but the conductance is generally modified due to the impurity-impurity interaction. When the doping breaks the two-fold rotational symmetry about the central line, the transport becomes spin dependent.
Nikkei Research Poll: March 2014 Nikkei Regular Telephone Interview Poll
Creators: name: Nikkei Research, Inc.
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Support for Shinzo Abe's Cabinet (2); reason for supporting Abe Cabinet (1); reason for not supporting Abe Cabinet (1); political party preference (2); consumption tax hike (3); future household income (1); future usage of nuclear power plants (1); policy focus for new budget (1); making concessions in foreign relations (1); future relations with North Korea (1); response to Crimea situation (1).
Gallup Poll # 1960-0637: Politics/Elections
Creators: name: Gallup
Publisher: name: Roper Center for Public Opinion Research
Year: 2020

description: Inflation (2); most important problems facing the country (1); political party best able to handle problems (2); voting in your neighborhood (4); interest in politics (1); frequency of voting (1); 1960 presidential election (14) Dwight Eisenhower job performance (1); political party able to keep US out of WWIII (1); most important branch of the military in the event of another World War (1); 1960 presidential debates (2); United Nations (3); spoken about the 1960 presidential election to others (2); campaign workers contacted respondent (2); participated in a political campaign (2); respect for US from other countries (1); politicians/foreign countries job performance (9); number of times respondent has left their homes yesterday (3); Congressional election (1); church attendance (1).
The Flavonoid Luteolin Worsens Chemical-Induced Colitis in NF-κBEGFP Transgenic Mice through Blockade of NF-κB-Dependent Protective Molecules
Creators: name: Karrasch, Thomas
name: Jobin, Christian
name: Kim, Joo-Sung
name: Jang, Byung Ik
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: BackgroundThe flavonoid luteolin has anti-inflammatory properties both in vivo and in vitro. However, the impact of luteolin on experimental models of colitis is unknown.Methodology/Principal FindingsTo address the therapeutic impact of luteolin, NF-κBEGFP transgenic mice were fed a chow diet containing 2% luteolin- or isoflavone-free control chow (AIN-76), and acute colitis was induced using 3% dextran sodium sulfate (DSS). Additionally, development of spontaneous colitis was evaluated in IL-10−/−;NF-κBEGFP transgenic mice fed 2% luteolin chow diet or control chow diet. Interestingly, NF-κBEGFP transgenic mice exposed to luteolin showed worse DSS-induced colitis (weight loss, histological scores) compared to control-fed mice, whereas spontaneous colitis in IL-10−/−;NF-κBEGFP mice was significantly attenuated. Macroscopic imaging of live resected colon showed enhanced EGFP expression (NF-κB activity) in luteolin-fed mice as compared to control-fed animals after DSS exposure, while cecal EGFP expression was attenuated in luteolin-fed IL-10−/− mice. Interestingly, confocal microscopy showed that EGFP positive cells were mostly located in the lamina propria and not in the epithelium. Caspase 3 activation was significantly enhanced whereas COX-2 gene expression was reduced in luteolin-fed, DSS-exposed NF-κBEGFP transgenic mice as assessed by Western blot and immunohistochemical analysis. In vitro, luteolin sensitized colonic epithelial HT29 cells to TNFα-induced apoptosis, caspase 3 activation, DNA fragmentation and reduced TNFα-induced C-IAP1, C-IAP2 and COX-2 gene expression.Conclusions/SignificanceWe conclude that while luteolin shows beneficial effects on spontaneous colitis, it aggravates DSS-induced experimental colitis by blocking NF-κB-dependent protective molecules in enterocytes.
Gallup Poll # 1963-0678: Kennedy Administration/Russia/Race Relations
Creators: name: Gallup
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: President John F. Kennedy job performance (1); Kennedy Administration and racial integration (1); preferred age at which son would begin military service (1); ideology of Senator Barry Goldwater (1); ideology of Governor Nelson Rockefeller (1); US-Russian relations (3); 1964 presidential election (6); racial integration/relations (1); television/radio to play speeches of presidential candidates (1); opinion of Kennedy Administration's spending record (2).
Evolution of Highly Pathogenic H5N1 Avian Influenza Viruses in Vietnam between 2001 and 2007
Creators: name: Cox, Nancy J.
name: Do, Hoa T.
name: Luo, Feng
name: Matsuoka, Yumiko
name: Jadhao, Samadhan
name: Klimov, Alexander
name: Lindstrom, Stephen E.
name: Wan, Xiu-Feng
name: Shu, Bo
name: Balish, Amanda
name: Carrel, Margaret
name: Smith, Catherine B.
name: Mai, Duong T.
name: Emch, Michael
name: Nguyen, Tung
name: Davis, C. Todd
name: Donis, Ruben O.
name: Inui, Kenjiro
name: Zhao, Zi-Ming
name: Nguyen, Cam V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Highly pathogenic avian influenza (HPAI) H5N1 viruses have caused dramatic economic losses to the poultry industry of Vietnam and continue to pose a serious threat to public health. As of June 2008, Vietnam had reported nearly one third of worldwide laboratory confirmed human H5N1 infections. To better understand the emergence, spread and evolution of H5N1 in Vietnam we studied over 300 H5N1 avian influenza viruses isolated from Vietnam since their first detection in 2001. Our phylogenetic analyses indicated that six genetically distinct H5N1 viruses were introduced into Vietnam during the past seven years. The H5N1 lineage that evolved following the introduction in 2003 of the A/duck/Hong Kong/821/2002-like viruses, with clade 1 hemagglutinin (HA), continued to predominate in southern Vietnam as of May 2007. A virus with a clade 2.3.4 HA newly introduced into northern Vietnam in 2007, reassorted with pre-existing clade 1 viruses, resulting in the emergence of novel genotypes with neuraminidase (NA) and/or internal gene segments from clade 1 viruses. A total of nine distinct genotypes have been present in Vietnam since 2001, including five that were circulating in 2007. At least four of these genotypes appear to have originated in Vietnam and represent novel H5N1 viruses not reported elsewhere. Geographic and temporal analyses of H5N1 infection dynamics in poultry suggest that the majority of viruses containing new genes were first detected in northern Vietnam and subsequently spread to southern Vietnam after reassorting with pre-existing local viruses in northern Vietnam. Although the routes of entry and spread of H5N1 in Vietnam remain speculative, enhanced poultry import controls and virologic surveillance efforts may help curb the entry and spread of new HPAI viral genes.
Kaiser Family Foundation/Washington Post/Harvard Poll: Survey of Detroit Area Residents
Creators: name: Harvard University
name: Kaiser Family Foundation
name: Washington Post
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Part of Detroit (1); length of time in counties within Detroit area (1); thinking about Detroit (1); future of Detroit (1); raising a family in Detroit (1); problems facing Detroit (1); Detroit's offerings (1); Detroit's economy (1); life satisfaction (1); standard of living (2); economic situation (1); worries (6); financial problems/problems paying for things (4); city vs. suburb, travel into (5); future of community (1); safe from crime (2); unification of people (2); division (1); racial discrimination (1); neighborhood gone up/down (1); quality of neighborhood amenities/services (3); five year neighborhood outlook (2); altering living conditions (1); planning to move (1); employment situation (1); housemate employment (1); income source (1); education level for best employment (1); working desired number of hours (1); likelihood of losing job (1); likelihood of pay/hour cut (1); housemate job experiences (3); employer's main line of business (2); parents working for manufacturing (1); children in manufacturing (3); best years ahead or behind (1); outlook for economic changes (1); economic changes influencing Detroit (1); confidence in Washington (1); confidence in Lansing government (1); confidence in local government (1); government's role in economy (1); government fostering innovation in economy (1); government programs to improve job growth (3); tax incentive priorities (1); impression of political parties (2); Barack Obama job performance (1); Obama handling certain issues (3); influence of government dealing with economic situation (5); auto industry problems hurting family (1); automobile industry making comeback (1); blame for auto industry failures (3); auto industry comeback improving Detroit economic situation (1); green energy in Detroit (1); government involvement with General Motors (1); Jennifer Granholm job performance (1); Dave Bing job performance (1); sacrifices to fix budget problems (1); political corruption (2); comparing Detroit to New Orleans after Katrina (1).
Pew Research Center Poll: Biennial Media Consumption Survey
Creators: name: Pew Research Center
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Satisfied/dissatisfied with direction of country (1); where would get news first in certain events (6); read daily newspaper[s] (3); watch TV news programs (3); listen to news on radio (2); watch major TV network evening news programs (1); followed news stories in past month (5); read magazines (2); how often watch/listen to certain TV and radio programs (23); how often read certain types of publications (5); enjoy keeping up with news (1); listen to radio shows that invite listeners to call in to discuss current events (1); feel overloaded with information/like having so much information available (1); Alan Greenspan (1); Federal Reserve Bank (1); Dow Jones Industrial (1); satisfied with choices on TV (2); follow different types of news (17); satisfied with media coverage of certain people/events (4); cable TV (2); political views (1); more important to get general information about events/news about personal interests (1); statements about news (4); use a computer (1); ever go online (1); online news (11); news sources (7); stock (4); decisions about how and where to invest money (2); how often get information about financial markets (1); sources for stock market updates and quotes for stocks/mutual funds (12); how often get information about investing (1); sources for information about investing (6); own certain items (6); 1996 presidential election (1).
Long time-scale behavior of the Blazhko effect from rectified Kepler data
Creators: name: Benkő, J. M.
name: Plachy, E.
name: Szabó, R.
name: Molnár, L.
name: Kolláth, Z.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: In order to benefit from the 4-year unprecedented precision of the Kepler data, we extracted light curves from the pixel photometric data of the Kepler space telescope for 15 Blazhko RR Lyrae stars. For collecting all the flux from a given target as accurately as possible, we defined tailor-made apertures for each star and quarter. In some cases the aperture finding process yielded sub-optimal result, because some flux have been lost even if the aperture contains all available pixels around the star. This fact stresses the importance of those methods that rely on the whole light curve instead of focusing on the extrema (O-C diagrams and other amplitude independent methods). We carried out detailed Fourier analysis of the light curves and the amplitude independent O-C diagram. We found 12 (80%) multiperiodically modulated stars in our sample. This ratio is much higher than previously found. Resonant coupling between radial modes, a recent theory to explain of the Blazhko effect, allows single, multiperiodic or even chaotic modulations. Among the stars with two modulations we found three stars (V355 Lyr, V366 Lyr and V450 Lyr) where one of the periods dominate in amplitude modulation, but the other period has larger frequency modulation amplitude. The ratio between the primary and secondary modulation periods is almost always very close to ratios of small integer numbers. It may indicate the effect of undiscovered resonances. Furthermore, we detected the excitation of the second radial overtone mode $f_2$ for three stars where this feature was formerly unknown. Our data set comprises the longest continuous, most precise observations of Blazhko RR Lyrae stars ever published. These data which is made publicly available will be unprecedented for years to come.
description: 19 pages, 17 figures, accepted for publication in Astrophys. J. Suppl. Rectified data are here: http://www.konkoly.hu/KIK/data.html
Siena Research Institute Poll: October 2011 Siena New York State Consumer Confidence Index
Creators: name: Siena Research Institute, Siena College
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Financial situation (1); future financial situation (1); New York business conditions (1); New York future economic situation (1); good time to buy (1); future purchases (5); effects of gasoline prices (1); effects of food prices (1); real estate market improvements (2); selling properties (2); buying properties (2); volunteer activities (2).
An apparatus for applying fire-like heat flux to bench-scale samples
Creators: name: Seweryn, Aleksandra
name: Lucherini, Andrea
name: Franssen, Jean-Marc
Publisher: name: figshare
Year: 2023
Subjects: Fire safety engineering

description: The research study presented in this paper concerns an experimental electricity-powered apparatus for applying fire-like heat flux to bench-scale samples. It consists of various elements, of which the most important are ceramic heating pads used to impose a defined heat flux on the exposed side of the sample mounted in a steel holder. The test method allows to control the heating pads’ temperature as well as to adjust the distance between the heating pads and the specimen to obtain heat fluxes up to 150 kW/m2. The thickness of the convective boundary layer at the heating pads’ surface is estimated to be around 3 cm, significantly lower than in case of gas-fired radiant panels. The performance of the apparatus was analysed in a case study on soda-lime-silica glass specimen. Experimental results were compared to numerical modelling. This analysis showed that a thermal exposure compared to the ISO 834 fire curve can be imposed on the exposed side of the specimen. There are many research possibilities for future applications of the presented experimental methodology: among others, tests with bigger specimens with heating pads surface up to 1.34 m2, and tests in controlled atmosphere.
Canadian Gallup Poll # 309
Creators: name: Canadian Institute Of Public Opinion (Gallup)
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Federal election vote intent(1); past federal elections vote(1); predictions for 1965(1); war with Russia, China(2); birth control(1); federal Parliament job performance(2); best choice for Prime Minister(1); labor unions(1); losing weight(2). Note: Demographics(10). Dropped: religion, language, car.
Canadian Gallup Poll # 351
Creators: name: Canadian Institute Of Public Opinion (Gallup)
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Federal election vote intent(1); past federal elections vote(1); UN approval(1); US capital in Canada(2); Quebec's separatism(2); current party preference(1); welfare system(1); political leaders approval(3). Note: Demographics(11).
Hippocampus Shape Analysis and Late-Life Depression
Creators: name: MacFall, James R.
name: Zhao, Zheen
name: Styner, Martin
name: Krishnan, K. Ranga R.
name: Taylor, Warren D.
name: Steffens, David C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Major depression in the elderly is associated with brain structural changes and vascular lesions. Changes in the subcortical regions of the limbic system have also been noted. Studies examining hippocampus volumetric differences in depression have shown variable results, possibly due to any volume differences being secondary to local shape changes rather than differences in the overall volume. Shape analysis offers the potential to detect such changes. The present study applied spherical harmonic (SPHARM) shape analysis to the left and right hippocampi of 61 elderly subjects with major depression and 43 non-depressed elderly subjects. Statistical models controlling for age, sex, and total cerebral volume showed a significant reduction in depressed compared with control subjects in the left hippocampus (F1,103 = 5.26; p = 0.0240) but not right hippocampus volume (F1,103 = 0.41; p = 0.5213). Shape analysis showed significant differences in the mid-body of the left (but not the right) hippocampus between depressed and controls. When the depressed group was dichotomized into those whose depression was remitted at time of imaging and those who were unremitted, the shape comparison showed remitted subjects to be indistinguishable from controls (both sides) while the unremitted subjects differed in the midbody and the lateral side near the head. Hippocampal volume showed no difference between controls and remitted subjects but nonremitted subjects had significantly smaller left hippocampal volumes with no significant group differences in the right hippocampus. These findings may provide support to other reports of neurogenic effects of antidepressants and their relation to successful treatment for depressive symptoms.
Vacancy Effects on Electric and Thermoelectric Properties of Zigzag Silicene Nanoribbons
Creators: name: An, R. L.
name: Wang, X. F.
name: Vasilopoulos, P.
name: Liu, Y. S.
name: Chen, A. B.
name: Dong, Y. J.
name: Zhai, M. X.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study the crystal reconstruction in the presence of monovacancies (MVs), divacancies (DVs) and linear vacancies (LVs) in a zigzag silicene nanoribbon (ZSiNR) with transversal symmetry. Their influence on the electric and thermoelectric properties is assessed by the density functional theory combined with the nonequilibrium Green's functions. In particular, we focus on the spin resolved conductance, magnetoresistance and current-voltage curves. A 5-atom-ring is formed in MVs, a 5-8-5 ring structure in DVs, and a 8-4-8-4 ring structure in LVs. The linear conductance becomes strongly spin dependent when the transversal symmetry is broken by vacancies especially if they are located on the ribbon's edges. The giant magnetoresistance can be smeared by asymmetric vacancies. Single spin negative differential resistance may appear in the presence of LVs and asymmetric MVs or DVs. A strong spin Seebeck effect is expected at room temperature in ZSiNRs with LVs.
Canadian Gallup Poll # 326
Creators: name: Canadian Institute Of Public Opinion (Gallup)
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Federal election vote intent(1); past federal elections vote(1); predictions for 1968(3); labor unions(1); threat to world peace(2); opinion about political leaders(3); Quebec's separatism(2); war in Vietnam(1); Medicare(1). Note: Demographics(11).
The insignificant evolution of the richness-mass relation of galaxy clusters
Creators: name: Andreon, S.
name: Congdon, P.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Applications (stat.AP)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: We analysed the richness--mass scaling of 23 very massive clusters at $0.15
description: A&A, in press. Fixed pdf generation problem
Three-Nucleon Forces
Creators: name: Sauer, Peter U.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The role of three-nucleon forces in ab initio calculations of nuclear systems is investigated. The difference between genuine and induced many-nucleon forces is emphasized. Induced forces arise in the process of solving the nuclear many-body problem as technical intermediaries towards calculationally converged results. Genuine forces make up the Hamiltonian; they represent the chosen underlying dynamics. The hierarchy of contributions arising from two-, three- and many-nucleon forces is discussed. Signals for the need of the inclusion of genuine three-nucleon forces are studied in nuclear systems, technically best under control, especially in three-nucleon and four-nucleon systems. Genuine three-nucleon forces are important for details in the decription of some observables. Their contributions to observables are small on the scale set by two-nucleon forces.
description: review, 31 pages, 10 figures
Identifying Determinants of Cullin Binding Specificity Among the Three Functionally Different Drosophila melanogaster Roc Proteins via Domain Swapping
Creators: name: Simms, Jeffrey R.
name: Duronio, Robert J.
name: Reynolds, Patrick J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: BackgroundCullin-dependent E3 ubiquitin ligases (CDL) are key regulators of protein destruction that participate in a wide range of cell biological processes. The Roc subunit of CDL contains an evolutionarily conserved RING domain that binds ubiquitin charged E2 and is essential for ubiquitylation. Drosophila melanogaster contains three highly related Roc proteins: Roc1a and Roc2, which are conserved in vertebrates, and Roc1b, which is specific to Drosophila. Our previous genetic data analyzing Roc1a and Roc1b mutants suggested that Roc proteins are functionally distinct, but the molecular basis for this distinction is not known.Methodology/Principal FindingsUsing co-immunoprecipitation studies we show that Drosophila Roc proteins bind specific Cullins: Roc1a binds Cul1-4, Roc1b binds Cul3, and Roc2 binds Cul5. Through domain swapping experiments, we demonstrate that Cullin binding specificity is strongly influenced by the Roc NH2-terminal domain, which forms an inter-molecular β sheet with the Cullin. Substitution of the Roc1a RING domain with that of Roc1b results in a protein with similar Cullin binding properties to Roc1a that is active as an E3 ligase but cannot complement Roc1a mutant lethality, indicating that the identity of the RING domain can be an important determinant of CDL function. In contrast, the converse chimeric protein with a substitution of the Roc1b RING domain with that of Roc1a can rescue the male sterility of Roc1b mutants, but only when expressed from the endogenous Roc1b promoter. We also identified mutations of Roc2 and Cul5 and show that they cause no overt developmental phenotype, consistent with our finding that Roc2 and Cul5 proteins are exclusive binding partners, which others have observed in human cells as well.ConclusionsThe Drosophila Roc proteins are highly similar, but have diverged during evolution to bind a distinct set of Cullins and to utilize RING domains that have overlapping, but not identical, function in vivo.
Thermal pairing and giant dipole resonance in highly excited nuclei
Creators: name: Dang, Nguyen Dinh
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Recent results are reported showing the effects of thermal pairing in highly excited nuclei. It is demonstrated that thermal pairing included in the phonon damping model (PDM) is responsible for the nearly constant width of the giant dipole resonance (GDR) at low temperature $T $ 170 MeV.
description: 6 pages, 4 figures, invited lecture at the 11th Spring Seminar on Nuclear Physics, Ischia May 12 - 16, 2014
Securing the future : the use of strategic foresight in the security sector
Creators: name: Habegger, Beat
Publisher: name: Geneva Centre for Security Policy
Year: 2022
Subjects: Sicherheitspolitik
Risiko
Global
Frühwarnsystem
363: Umwelt- und Sicherheitsprobleme

description: The pace of change has accelerated in all areas of society. Increasing geopolitical tensions, deeper socio-economic divides, rapid technological changes, and the threat of environmental disasters have created the perception that political and economic realities are shifting and society must be reshaped. Organisations of all kinds must respond to these changes and the resulting uncertainties to successfully navigate into the future.

Security organisations – defence ministries, intelligence agencies, police forces or armed forces – are no exception. Like others, they need to improve their capacities to look ahead and think beyond. The latter is the ability to think beyond system boundaries and to integrate more perspectives into their strategic risk assessments than they were used to in the past. Security organisations must therefore broaden their scope in terms of relevant policy areas far beyond the focus on traditional security issues. On the other hand, to look ahead is the ability to think further into the future than previously seemed necessary. Security organisations must therefore extend the time horizon of their strategic outlook to five, ten or even thirty years to capture all the developments that are potentially relevant to the fulfilment of their mission.

This analysis places strategic foresight at the heart of organisational or management perspectives that help security organisations to meet the challenges they face. By sharpening their strategic foresight, security organisations and professionals can identify significant developments early on and create resilient pictures of possible future environments. This enables them to anticipate threats and opportunities, think and act in terms of alternatives, and optimise their strategic direction and operational management.
Canadian Gallup Poll # 278
Creators: name: Canadian Institute Of Public Opinion (Gallup)
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Federal elections vote intent(1); past federal elections vote(1); pay raises for railroad workers(2); space exploration(3); compact cars made in US, Canada(3); reading habits(2); euthanasia(3); labor unions(4); chances of world war(1). Note: Demographics(15). Added: children, drivers' license.
AirDet: Few-Shot Detection without Fine-tuning for Autonomous Exploration
Creators: name: Li, Bowen
name: Wang, Chen
name: Reddy, Pranay
name: Kim, Seungchan
name: Scherer, Sebastian
Publisher: name: arXiv
Year: 2021
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Few-shot object detection has attracted increasing attention and rapidly progressed in recent years. However, the requirement of an exhaustive offline fine-tuning stage in existing methods is time-consuming and significantly hinders their usage in online applications such as autonomous exploration of low-power robots. We find that their major limitation is that the little but valuable information from a few support images is not fully exploited. To solve this problem, we propose a brand new architecture, AirDet, and surprisingly find that, by learning class-agnostic relation with the support images in all modules, including cross-scale object proposal network, shots aggregation module, and localization network, AirDet without fine-tuning achieves comparable or even better results than many fine-tuned methods, reaching up to 30-40% improvements. We also present solid results of onboard tests on real-world exploration data from the DARPA Subterranean Challenge, which strongly validate the feasibility of AirDet in robotics. To the best of our knowledge, AirDet is the first feasible few-shot detection method for autonomous exploration of low-power robots. The code and pre-trained models are released at https://github.com/Jaraxxus-Me/AirDet.
description: 23 pages, 9 figures
Canadian Gallup Poll # 384
Creators: name: Canadian Institute Of Public Opinion (Gallup)
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Federal election vote intent(1); past federal elections vote(1); two-party system for Canada(1); unification of churches(1); 1976 Montreal Olympic Games(1); women in ministry(1); greatest problem facing city/community(1); Canada-US relations(1); unemployment(3); government anti-inflation policy(2). Note: Demographics(14).
Kepler detection of a new extreme planetary system orbiting the subdwarf-B pulsator KIC10001893
Creators: name: Silvotti, R.
name: Charpinet, S.
name: Green, E.
name: Fontaine, G.
name: Telting, J. H.
name: Ostensen, R. H.
name: Van Grootel, V.
name: Baran, A. S.
name: Schuh, S.
name: Machado, L. Fox
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: KIC10001893 is one out of 19 subdwarf-B (sdB) pulsators observed by the Kepler spacecraft in its primary mission. In addition to tens of pulsation frequencies in the g-mode domain, its Fourier spectrum shows three weak peaks at very low frequencies, which is too low to be explained in terms of g modes. The most convincing explanation is that we are seeing the orbital modulation of three Earth-size planets (or planetary remnants) in very tight orbits, which are illuminated by the strong stellar radiation. The orbital periods are P1=5.273, P2=7.807, and P3=19.48 hours, and the period ratios P2/P1=1.481 and P3/P2=2.495 are very close to the 3:2 and 5:2 resonances, respectively. One of the main pulsation modes of the star at 210.68 μHz corresponds to the third harmonic of the orbital frequency of the inner planet, suggesting that we see, for the first time in an sdB star, g-mode pulsations tidally excited by a planetary companion. The extreme planetary system that emerges from the Kepler data is very similar to the recent discovery of two Earth-size planets orbiting the sdB pulsator KIC05807616 (Charpinet et al. 2011a).
description: 6 pages, 5 figures, accepted for publication in Astronomy and Astrophysics
Metabolic and Immune Activation Effects of Treatment Interruption in Chronic HIV-1 Infection: Implications for Cardiovascular Risk
Creators: name: Tebas, Pablo
name: Matining, Roy
name: Schmitz, John
name: Powderly, William G.
name: Valdez, Hernan
name: Myers, Laurie
name: Katzenstein, David
name: Jahed, Nasreen
name: Henry, William Keith
name: Weng-Cherng, Deborah
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: BackgroundConcern about costs and antiretroviral therapy (ART)-associated toxicities led to the consideration of CD4 driven strategies for the management of HIV. That approach was evaluated in the SMART trial that reported an unexpected increase of cardiovascular events after treatment interruption (TI). Our goal was to evaluate fasting metabolic changes associated with interruption of antiretroviral therapy and relate them to changes of immune activation markers and cardiovascular risk.MethodologyACTG 5102 enrolled 47 HIV-1-infected subjects on stable ART, with <200 HIV RNA copies/mL and CD4 cell count ≥500 cells/µL. Subjects were randomly assigned to continue ART for 18 weeks with or without 3 cycles of interleukin-2 (IL-2) (cycle = 4.5 million IU sc BID x 5 days every 8 weeks). After 18 weeks ART was discontinued in all subjects until the CD4 cell count dropped below 350 cells/µL. Glucose and lipid parameters were evaluated every 8 weeks initially and at weeks 2, 4, 8 and every 8 weeks after TI. Immune activation was evaluated by flow-cytometry and soluble TNFR2 levels.Principal FindingsBy week 8 of TI, levels of total cholesterol (TC) (median (Q1, Q3) (−0.73 (−1.19, −0.18) mmol/L, p<0.0001), LDL, HDL cholesterol (−0.36(−0.73,−0.03)mmol/L, p = 0.0007 and −0.05(−0.26,0.03), p = 0.0033, respectively) and triglycerides decreased (−0.40 (−0.84, 0.07) mmol/L, p = 0.005). However the TC/HDL ratio remained unchanged (−0.09 (−1.2, 0.5), p = 0.2). Glucose and insulin levels did not change (p = 0.6 and 0.8, respectively). After TI there was marked increase in immune activation (CD8+/HLA-DR+/CD38+ cells, 34% (13, 43), p<0.0001) and soluble TNFR2 (1089 ng/L (−189, 1655), p = 0.0008) coinciding with the rebound of HIV viremia.ConclusionsOur data suggests that interrupting antiretroviral therapy does not reduce cardiovascular disease (CVD) risk, as the improvements in lipid parameters are modest and overshadowed by the decreased HDL levels. Increased immune cell activation and systemic inflammatory responses associated with recrudescent HIV viremia may provide a more cogent explanation for the increased cardiovascular risk associated with treatment interruption and HIV infection.Trial RegistrationClinicalTrials.gov NCT00015704