title: ÐÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ ÐºÐ°Ð»ÑÐ¿Ð°Ð¸Ð½Ð¾Ð² Ð² Ð¼Ð¾Ð·Ð³Ðµ ÐºÑÑÑ Ð¿ÑÐ¸ Ð¸Ð½ÑÐ¾ÐºÑÐ¸ÐºÐ°ÑÐ¸Ð¸ 3-Ð½Ð¸ÑÑÐ¾Ð¿ÑÐ¾Ð¿Ð¸Ð¾Ð½Ð¾Ð²Ð¾Ð¹ ÐºÐ¸ÑÐ»Ð¾ÑÐ¾Ð¹
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: The activity of calpain in the rat's brain with intoxocation of 3-nitropropionic acid
Creators: name: ÐÐ°ÑÑÐ°Ðº, ÐÑÑ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: 3-Ð½Ð¸ÑÑÐ¾Ð¿ÑÐ¾Ð¿Ð¸Ð¾Ð½Ð¾Ð²Ð°Ñ ÐºÐ¸ÑÐ»Ð¾ÑÐ°
ÑÑÐºÑÐ¸Ð½Ð°ÑÐ´ÐµÐ³Ð¸Ð´ÑÐ¾Ð³ÐµÐ½Ð°Ð·Ð°
ÐºÐ°Ð»ÑÐ¿Ð°Ð¸Ð½Ñ
Ð´Ð¾ÑÐ°Ð¼Ð¸Ð½
3-nitropropionic acid
succinate dehydrogenase
calpain
dopamin

description: 3-Ð½Ð¸ÑÑÐ¾Ð¿ÑÐ¾Ð¿Ð¸Ð¾Ð½Ð¾Ð²Ð°Ñ ÐºÐ¸ÑÐ»Ð¾ÑÐ° â Ð¼Ð¸ÑÐ¾ÑÐ¾Ð½Ð´ÑÐ¸Ð°Ð»ÑÐ½ÑÐ¹ ÑÐ¾ÐºÑÐ¸Ð½, Ð¸Ð½Ð³Ð¸Ð±Ð¸ÑÑÑÑÐ¸Ð¹ ÑÑÐºÑÐ¸Ð½Ð°ÑÐ´ÐµÐ³Ð¸Ð´ÑÐ¾Ð³ÐµÐ½Ð°Ð·Ñ (II ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑ Ð´ÑÑÐ°ÑÐµÐ»ÑÐ½Ð¾Ð¹ ÑÐµÐ¿Ð¸ Ð¿ÐµÑÐµÐ½Ð¾ÑÐ° ÑÐ»ÐµÐºÑÑÐ¾Ð½Ð¾Ð²). ÐÐ°Ð½Ð½ÑÐ¹ ÑÐ¾ÐºÑÐ¸Ð½ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·ÑÐµÑÑÑ Ð´Ð»Ñ Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð½ÐµÐ¹ÑÐ¾Ð´ÐµÐ³ÐµÐ½ÐµÑÐ°ÑÐ¸Ð²Ð½ÑÑ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ð¹. ÐÐ´Ð½Ð°ÐºÐ¾ Ð¼Ð½Ð¾Ð³Ð¸Ðµ Ð¿ÑÐ¾ÑÐµÑÑÑ, Ð¿ÑÐ¸Ð²Ð¾Ð´ÑÑÐ¸Ðµ Ðº Ð¿Ð¾Ð²ÑÐµÐ¶Ð´ÐµÐ½Ð¸Ñ Ð½ÐµÑÐ²Ð½Ð¾Ð¹ ÑÐºÐ°Ð½Ð¸ Ð¿Ð¾Ð´ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸ÐµÐ¼ 3-Ð½Ð¿Ðº, ÐµÑÐµ Ð½Ðµ Ð´Ð¾ ÐºÐ¾Ð½ÑÐ° ÑÑÐ½Ñ. Ð ÑÐ²ÑÐ·Ð¸ Ñ ÑÑÐ¸Ð¼, ÑÐµÐ»ÑÑ Ð½Ð°ÑÑÐ¾ÑÑÐµÐ³Ð¾ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð±ÑÐ»Ð¾: Ð² ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ñ Ð² ÑÐ¸ÑÑÐµÐ¼Ðµ in vitro Ð¸ in vivo Ð¿ÑÐ¾Ð²ÐµÑÐ¸ÑÑ ÑÐ¿Ð¾ÑÐ¾Ð±Ð½Ð¾ÑÑÑ 3-Ð½Ð¿Ðº Ð¼Ð¾Ð´ÑÐ»Ð¸ÑÐ¾Ð²Ð°ÑÑ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ ÐºÐ°Ð»ÑÑÐ¸Ð¹-Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼ÑÑ ÑÐ¸ÑÑÐµÐ¸Ð½Ð¾Ð²ÑÑ Ð¿ÑÐ¾ÑÐµÐ°Ð· ÐºÐ°Ð»ÑÐ¿Ð°Ð¸Ð½Ð¾Ð², Ð³Ð¸Ð¿ÐµÑÐ°ÐºÑÐ¸Ð²Ð°ÑÐ¸Ñ ÐºÐ¾ÑÐ¾ÑÑÑ ÑÐ²Ð»ÑÐµÑÑÑ Ð¾Ð´Ð½Ð¸Ð¼ Ð¸Ð· Ð·Ð²ÐµÐ½ÑÐµÐ² Ð½ÐµÐ¹ÑÐ¾Ð´ÐµÐ³ÐµÐ½ÐµÑÐ°ÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¾ÑÐµÑÑÐ°. ÐÐ¿ÐµÑÐ²ÑÐµ Ð±ÑÐ»Ð¾ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð½Ð¾, ÑÑÐ¾ Ð°Ð¿Ð¿Ð»Ð¸ÐºÐ°ÑÐ¸Ñ 3-Ð½Ð¿Ðº Ðº ÑÐ¸Ð½Ð°Ð¿ÑÐ¾ÑÐ¾Ð¼Ð°Ð¼ Ð²ÑÐ·ÑÐ²Ð°ÐµÑ Ð°ÐºÑÐ¸Ð²Ð°ÑÐ¸Ñ m-ÐºÐ°Ð»ÑÐ¿Ð°Ð¸Ð½Ð°, Ð½Ð¾ Ð½Ðµ ÑÐ¿Ð¾ÑÐ¾Ð±ÑÑÐ²ÑÐµÑ Ð²ÑÑÐ²Ð¾Ð±Ð¾Ð¶Ð´ÐµÐ½Ð¸Ñ ÐºÐ°Ð»ÑÐ¿Ð°Ð¸Ð½Ð¾Ð² Ð¸Ð· ÑÐ¸Ð½Ð°Ð¿ÑÐ¾ÑÐ¾Ð¼; ÐºÑÑÑÐ¾Ð²Ð¾Ðµ Ð¸Ð½ÑÑÐ°Ð¿ÐµÑÐ¸ÑÐ¾Ð½ÐµÐ°Ð»ÑÐ½Ð¾Ðµ Ð²Ð²ÐµÐ´ÐµÐ½Ð¸Ðµ 3-Ð½Ð¿Ðº ÐºÑÑÑÐ°Ð¼ Ð¿ÑÐ¸Ð²Ð¾Ð´Ð¸Ñ Ðº ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ Ð´Ð²Ð¸Ð³Ð°ÑÐµÐ»ÑÐ½ÑÑ Ð½Ð°ÑÑÑÐµÐ½Ð¸Ð¹, ÑÐ½Ð¸Ð¶ÐµÐ½Ð¸Ñ ÑÐ¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸Ñ Ð´Ð¾ÑÐ°Ð¼Ð¸Ð½Ð° Ð² ÑÑÑÐ¸Ð°ÑÑÐ¼Ðµ Ð¸ ÑÐ²ÐµÐ»Ð¸ÑÐµÐ½Ð¸Ñ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÐºÐ°Ð»ÑÐ¿Ð°Ð¸Ð½Ð¾Ð² (m- Ð¸ Ð¼Ñ) Ð² ÐºÐ»ÐµÑÐºÐ°Ñ Ð³Ð¸Ð¿Ð¿Ð¾ÐºÐ°Ð¼Ð¿Ð°.
description: 3-nitropropionic acid is a mitochondrial toxin that inhibits succinate dehydrogenase (II complex of the respiratory electron transfer chain). This toxin is used to model neurodegenerative diseases. However, many of the processes that lead to damage neurons under the influence of 3-nitropropionic acid are not yet fully clear. In this regard, the purpose of this study was to test the ability of 3- nitropropionic acid to modulate the activity of calcium-dependent cysteine proteases of calpains in experiments in vitro and in vivo. Their activation is one of the parts of the neurodegenerative process. For the first time, it was shown that the application of 3-nitropropionic acid to synaptosomes causes activation of m-calpain, but does not contribute to the release of calpain from synaptosomes; course intraperitoneal administration of 3-NPC to rats leads to the development of motor disorders, a decrease in the content of dopamine in the striatum and an increase in the activity of calpain (m - and mu) in hippocampal cells.