title: Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð¾Ð³Ð¾ Ð¾Ð±ÐµÑÐ¿ÐµÑÐµÐ½Ð¸Ñ Ð´Ð»Ñ ÑÐ»ÐµÐºÑÑÐ¾ÐºÐ°ÑÐ´Ð¸Ð¾Ð³ÑÐ°ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° ÑÐ°Ð±Ð¾ÑÑ ÑÐµÑÐ´ÑÐ° ÐºÑÑÑÑ Ð¿ÑÐ¸ Ð¸Ð·ÑÑÐµÐ½Ð¸Ð¸ ÑÐµÑÐ´ÐµÑÐ½Ð¾Ð¹ Ð½ÐµÐ´Ð¾ÑÑÐ°ÑÐ¾ÑÐ½Ð¾ÑÑÐ¸
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Development of software for electrocardiographic analysis of rat heart function in the study of heart failure
Creators: name: ÐÐ¾Ð²Ð¸ÐºÐ¾Ð²Ð°, ÐÐ²Ð³ÐµÐ½Ð¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2021
Subjects: ÐÐ²ÑÐ¾Ð¼Ð°ÑÐ¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐµ ÑÐ¸ÑÑÐµÐ¼Ñ Ð¿ÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ
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description: Ð¦ÐµÐ»Ñ Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ Ð·Ð°ÐºÐ»ÑÑÐ°Ð»Ð°ÑÑ Ð² ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐµ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð¾Ð³Ð¾ Ð¾Ð±ÐµÑÐ¿ÐµÑÐµÐ½Ð¸Ñ Ð´Ð»Ñ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° ÑÐ»ÐµÐºÑÑÐ¾ÐºÐ°ÑÐ´Ð¸Ð¾Ð³ÑÐ°Ð¼Ð¼Ñ Ð¼ÐµÐ»ÐºÐ¸Ñ Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÑ (Ð³ÑÑÐ·ÑÐ½Ð¾Ð²) Ð¸ Ð°Ð¿ÑÐ¾Ð±Ð°ÑÐ¸Ð¸ ÑÑÐ¾Ð³Ð¾ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð¾Ð³Ð¾ Ð¾Ð±ÐµÑÐ¿ÐµÑÐµÐ½Ð¸Ñ Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ ÐºÑÑÑÐ¸Ð½ÑÑ Ð¼Ð¾Ð´ÐµÐ»ÐµÐ¹ Ð´Ð¸Ð°Ð±ÐµÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÐºÐ°ÑÐ´Ð¸Ð¾Ð¼Ð¸Ð¾Ð¿Ð°ÑÐ¸Ð¸ Ð¸ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½Ð¾Ð³Ð¾ Ð¸Ð½ÑÐ°ÑÐºÑÐ° Ð¼Ð¸Ð¾ÐºÐ°ÑÐ´Ð°. ÐÐ»Ñ Ð´Ð¾ÑÑÐ¸Ð¶ÐµÐ½Ð¸Ñ Ð¿Ð¾ÑÑÐ°Ð²Ð»ÐµÐ½Ð½Ð¾Ð¹ ÑÐµÐ»Ð¸ Ð±ÑÐ»Ð¸ ÑÑÐ¾ÑÐ¼ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ñ ÑÐ»ÐµÐ´ÑÑÑÐ¸Ðµ Ð·Ð°Ð´Ð°ÑÐ¸: 1) Ð¡Ð¾Ð·Ð´Ð°ÑÑ Ð°Ð»Ð³Ð¾ÑÐ¸ÑÐ¼, Ð¿Ð¾ ÐºÐ¾ÑÐ¾ÑÐ¾Ð¼Ñ Ð±ÑÐ´ÐµÑ ÑÐ°Ð±Ð¾ÑÐ°ÑÑ Ð±ÑÐ´ÑÑÐµÐµ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð¾Ðµ Ð¾Ð±ÐµÑÐ¿ÐµÑÐµÐ½Ð¸Ðµ; 2) ÐÑÐ¿Ð¾Ð»ÑÐ·ÑÑ ÑÐ¸ÑÑÐµÐ¼Ñ Ð¼Ð°ÑÐµÐ¼Ð°ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ MATLAB (Ð²ÐµÑÑÐ¸Ð¸ R2018b), ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°ÑÑ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð¾Ðµ Ð¾Ð±ÐµÑÐ¿ÐµÑÐµÐ½Ð¸Ðµ. 3) ÐÑÐ¾Ð²ÐµÑÑÐ¸ Ð°Ð¿ÑÐ¾Ð±Ð°ÑÐ¸Ñ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð¾Ð³Ð¾ Ð¾Ð±ÐµÑÐ¿ÐµÑÐµÐ½Ð¸Ñ Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ ÐºÑÑÑÐ¸Ð½Ð¾Ð¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸ ÑÑÑÐµÐ¿ÑÐ¾Ð·Ð¾ÑÐ¾ÑÐ¸Ð½Ð¾Ð²Ð¾Ð³Ð¾ ÑÐ°ÑÐ°ÑÐ½Ð¾Ð³Ð¾ Ð´Ð¸Ð°Ð±ÐµÑÐ° Ð¸ Ð¿ÑÐµÐ´Ð´Ð¸Ð°Ð±ÐµÑÐ°; 4) ÐÑÐ¾Ð²ÐµÑÑÐ¸ Ð°Ð¿ÑÐ¾Ð±Ð°ÑÐ¸Ñ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð¾Ð³Ð¾ Ð¾Ð±ÐµÑÐ¿ÐµÑÐµÐ½Ð¸Ñ Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ ÐºÑÑÑÐ¸Ð½Ð¾Ð¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð¸ÑÐµÐ¼Ð¸Ð¸-ÑÐµÐ¿ÐµÑÑÑÐ·Ð¸Ð¸; Ð Ð°Ð±Ð¾ÑÐ° Ð±ÑÐ»Ð° Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð° Ð½Ð° Ð±Ð°Ð·Ðµ ÐÐ½ÑÑÐ¸ÑÑÑÐ° ÑÐ²Ð¾Ð»ÑÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ¸Ð·Ð¸Ð¾Ð»Ð¾Ð³Ð¸Ð¸ Ð¸ Ð±Ð¸Ð¾ÑÐ¸Ð¼Ð¸Ð¸ Ð¸Ð¼. Ð. Ð. Ð¡ÐµÑÐµÐ½Ð¾Ð²Ð° Ð Ð¾ÑÑÐ¸Ð¹ÑÐºÐ¾Ð¹ Ð°ÐºÐ°Ð´ÐµÐ¼Ð¸Ð¸ Ð½Ð°ÑÐº (ÐÐ­Ð¤Ð Ð ÐÐ) Ð² Ð³ÑÑÐ¿Ð¿Ðµ ÐÐµÐ¹ÑÐ¾ÑÐµÐ³ÑÐ»ÑÑÐ¸Ð¸ Ð¼ÑÑÐµÑÐ½Ð¾Ð¹ ÑÑÐ½ÐºÑÐ¸Ð¸ Ð¿Ð¾Ð´ ÑÑÐºÐ¾Ð²Ð¾Ð´ÑÑÐ²Ð¾Ð¼ Ðº.Ð±.Ð½, Ð².Ð½.Ñ. ÐÐ¾Ð±ÑÐµÑÐ¾Ð²Ð° ÐÐ°ÐºÑÐ¸Ð¼Ð° ÐÐµÐ¾ÑÐ³Ð¸ÐµÐ²Ð¸ÑÐ°.
description: The aim of presented work was to develop computer software for the analysis of small animals (rodent) electrocardiograms and to test this software using electro-cardiographic recordings obtained in rat models of diabetic cardiomyopathy and ex-perimental myocardial infarction. To achieve this goal, the following tasks were formulated: 1) Create an algorithm that will run the future software; 2) Using the MATLAB mathematical programming system (version R2018b), develop the software; 3) Testing of the developed software using a rat model of streptozotocin diabe-tes mellitus and prediabetes; 4) Testing of the developed software using a rat model of ischemia-reperfusion; 5) Draw conclusions about the work of the program. The research was conducted on the basis of the Sechenov institute of evolu-tionary physiology and biochemistry Russian academy of sciences (IEFB RAS) in the group of neuroregulation of muscle function under the guidance of Maxim G. Do-bretsov, PhD.