cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
[PDF/Kindle] Le livre de l'intranquillité by Fernando Pessoa
Creators: name: Herrmann
Publisher: name: Zenodo
Year: 2024

description: Le livre de l'intranquillité pan Fernando Pessoa

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Le livre de l'intranquillité

Fernando Pessoa

Nb. de pages: 610

Format: Pdf, ePub, MOBI, FB2

ISBN: 9782267021776

Editeur: Christian Bourgois

Date de parution: 2011

 

 

 

Télécharger gratuitement ebook joomla Le livre de l'intranquillité en francais 9782267021776 iBook par Fernando Pessoa

 

Overview

« En ces heures où le paysage est une auréole de vie, j'ai élevé, mon amour, dans le silence de mon intranquillité, ce livre étrange... » qui alterne chronique du quotidien et méditation transcendante. Le livre de l'intranquillité est le journal que Pessoa a tenu pendant presque toute sa vie, en l'attribuant à un modeste employé de bureau de Lisbonne , Bernardo Soares. Sans ambition terrestre, mais affamé de grandeur spirituelle, réunissant esprit critique et imagination déréglée, attentif aux formes et aux couleurs du monde extérieur mais aussi observateur de « l'infiniment petit de l'espace du dedans », Bernardo Soares, assume son "intranquillité" pour mieux la dépasser et, grâce à l'art, aller à l'extrémité de lui-même, à cette frontière de notre condition ou les mystiques atteignent la plénitude « parce qu'ils sont vidés de tout le vide du monde ». Il se construit un univers personnel vertigineusement irréel, et pourtant plus vrai en un sens que le monde réel. Le livre de l’intranquillité est considéré comme le chef-d’oeuvre de Fernando Pessoa.
Recently Identified Factors that Regulate Hemostasis and Thrombosis
Creators: name: Mackman, Nigel
name: Geddings, Julia E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The blood coagulation cascade is essential for hemostasis but excessive activation can cause thrombosis. Importantly, recent studies have identified factors that contribute to thrombosis but not hemostasis. These include factor XII (FXII), tissue factor-positive microparticles (MPs) and neutrophil extracellular traps (NETs). Recent studies have shown that FXII plays a role in thrombosis but not hemostasis. FXII is activated in vivo by a variety of negatively-charged polyphosphates, which include extracellular RNA, DNA and inorganic polyphosphate (PolyP) that are released during cell damage and infection. These findings have triggered the development of nucleic acid-binding polymers as a new class of anticoagulant drug. Other studies have analyzed the role of MPs in experimental thrombosis. MPs are small membrane vesicles released from activated or apoptotic cells. We and others have found that tissue factor-positive MPs enhance thrombosis in mouse models and are elevated in the plasma of pancreatic cancer patients. Finally, NETs have been shown to contribute to experimental venous thrombosis in mouse models and are present in human thrombi. NETs are composed of chromatin fibers that are released from neutrophils undergoing cell death. NETs can capture platelets and increase fibrin deposition. The recent advances in our understanding of the factors contributing to thrombosis in animal models provide new opportunities for the development of safer anticoagulant drugs.
Age-Related Effects on the Potency of Human Adipose-Derived Stem Cells: Creation and Evaluation of Superlots and Implications for Musculoskeletal Tissue Engineering Applications
Creators: name: Bodle, Josephine C.
name: Bernacki, Susan H.
name: Loboa, Elizabeth G.
name: Hardin, Joseph W.
name: Hluck, Brandon H.
name: Teeter, Stephanie D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Human adipose-derived stem cells (hASC) are now a prevalent source of adult stem cells for studies in tissue engineering and regenerative medicine. However, researchers utilizing hASC in their investigations often encounter high levels of donor-to-donor variability in hASC differentiation potential. Because of this, conducting studies with this primary cell type can require extensive resources to generate statistically significant data. We present a method to generate pooled donor cell populations, termed “superlots,” containing cell populations derived from four to five age-clustered donors. The goal of generating these superlots was to 1) increase experimental throughput, 2) to utilize assay resources more efficiently, and 3) to begin to establish global hASC differentiation behaviors that may be associated with donor age. With our superlot approach, we have validated that pooled donor cell populations exhibit proliferative activity representing the combined behavior of each individual donor cell line. Further, the superlots also exhibit differentiation levels roughly approximating the average combined differentiation levels of each individual donor cell line. We established that high donor-to-donor variability exists between the pre-, peri-, and postmenopausal age groupings and that proliferation and differentiation characteristics can vary widely, independent of age. Interestingly, we did observe that cell lines derived from postmenopausal donors demonstrated a relatively high proclivity for osteogenic differentiation and a relatively lowered proclivity for adipogenic differentiation as compared with cells derived from pre- and perimenopausal donors. In general, superlots effectively represented the average differentiation behavior of each of their contributing cell populations and could provide a powerful tool for increasing experimental throughput to more efficiently utilize resources when studying hASC differentiation.
Supplementary Table 7 from Taxonomy assignment approach determines the efficiency of identification of OTUs in marine nematodes.
Creators: name: Holovachov, Oleksandr
name: Haenel, Quiterie
name: Bourlat, Sarah J.
name: Jondelius, Ulf
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60301 Animal Systematics and Taxonomy
subject: 60310 Plant Systematics and Taxonomy

description: Results of phylogeny-based taxonomy assignment using mothur and PaPaRa-based alignments.
Role of slotting fees and trade promotions in shaping how tobacco is marketed in retail stores
Creators: name: Bloom, Paul N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: OBJECTIVE—To examine how the retail environment in which tobacco is sold has changed because of the slotting fees and trade promotions paid by the tobacco companies. Public policy options for dealing with this environment are also evaluated.DATA SOURCES—A literature review, telephone interviews, and observation.RESULTS—The tobacco companies have been dramatically increasing the volume of slotting fees and trade promotions they pay to retailers, creating a more tobacco friendly retail environment containing self service displays and ample point-of-sale advertising. Critics express concern that these payments have kept prices lower and more varied than they might be otherwise, created more opportunities for pilferage and underage selling, and provided more youth exposure to tobacco promotions. Public policy makers could either ban these payments, institute policies designed to mitigate their harmful effects, or leave the situation as it is, relying on enforcement of existing statutes as well as market forces to reduce harm. Actions that might mitigate harmful effects would include putting minimum retail prices on tobacco products, banning self service displays, requiring retailers to be licensed, and adding more warning signs at the point of sale.CONCLUSION—Additional research is needed before determining the most appropriate public policy stance.Keywords: promotion; slotting; retailing; merchandising
Increasing availability and consumption of single cigarettes: trends and implications for smoking cessation from the ITC Mexico Survey
Creators: name: Reynales-Shigematsu, Luz Myriam
name: Hall, Marissa G.
name: Arillo-Santillán, Edna
name: Fleischer, Nancy L.
name: Thrasher, James F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Determine (1) trends in single cigarette availability and purchasing in Mexico, and (2) the association between neighborhood access to singles and cessation behavior among adult Mexican smokers.
DOWNLOADS 28 ans d'angoisse  - Parce qu'il est possible de vivre avec !
Creators: name: Mason
Publisher: name: Zenodo
Year: 2024

description: 28 ans d'angoisse - Parce qu'il est possible de vivre avec ! pan Noholito, Stéphane Faury, Gabriele Musolesi

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28 ans d'angoisse - Parce qu'il est possible de vivre avec !

Noholito, Stéphane Faury, Gabriele Musolesi

Nb. de pages: 191

Format: Pdf, ePub, MOBI, FB2

ISBN: 9782266330299

Editeur: Pocket

Date de parution: 2023

 

 

 

Télécharger des livres joomla 28 ans d'angoisse - Parce qu'il est possible de vivre avec ! par Noholito, Stéphane Faury, Gabriele Musolesi en francais

 

Overview

Un livre façon journal intime à la fois sensible et drôle dans lequel Noholito parle des crises d'angoisse. Noholito, sans fard ni tabou. A toi, lectrice ou lecteur, Avec ce journal intime, tu tiens un peu de ma vie entre tes mains. (Ne serre pas si fort miskine.) Tu me connais pour mon humour, mais tu sais bien que parfois, derrière, on se cache un peu, on tait certaines choses. J'ai passé 28 ans de ma vie à ne pas m'écouter et à me trimballer des maladies psychologiques qui m'ont empêché de vivre. J'ai voulu vaincre mes crises d'angoisse avant d'essayer de comprendre d'où elles venaient. C'était là mon erreur, gourgandine ! Il faut plonger dedans et se poser, pour les comprendre... Et pour enfin s'accepter. Parce que c'est possible ! Et aujourd'hui je peux te le dire : James aime James. (Oui, c'est mon vrai prénom, gousse d'ail.) Ce livre, je l'ai d'abord écrit pour moi, mais j'espère qu'il pourra te servir et t'apporter les conseils que j'aurais voulu avoir. La période qu'on vit n'est pas rose... mais parfois le ciel se dégage et devient bleu. (Ou lavande ! J'adore ce lavande ! )
Higher Rank Numerical Ranges of Normal Operators and unitary dilations
Creators: name: Dey, Pankaj
name: Mukherjee, Mithun
Publisher: name: arXiv
Year: 2021
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 47A12, 47A20, 47B15, 15A60, 81P68

description: We describe here the higher rank numerical range, as defined by Choi, Kribs and Zyczkowski, of a normal operator on an infinite dimensional Hilbert space in terms of its spectral measure. This generalizes a result of Avendano for self-adjoint operators. An analogous description of the numerical range of a normal operator by Durszt is derived for the higher rank numerical range as an immediate consequence. It has several interesting applications. We show using Durszt's example that there exists a normal contraction $T$ for which the intersection of the higher rank numerical ranges of all unitary dilations of $T$ contains the higher rank numerical range of $T$ as a proper subset. Finally, we strengthen and generalize a result of Wu by providing a necessary and sufficient condition for the higher rank numerical range of a normal contraction being equal to the intersection of the higher rank numerical ranges of all possible unitary dilations of it.
description: 21 pages
Using Car-Parrinello simulations and microscopic order descriptors to reveal two locally favored structures with distinct molecular dipole moments and dynamics in ambient liquid water
Creators: name: Skarmoutsos, Ioannis
name: Franzese, Giancarlo
name: Guardia, Elvira
Publisher: name: arXiv
Year: 2022
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Water is essential for life and technological applications, mainly for its unique thermodynamic and dynamic properties, often anomalous or counterintuitive. These anomalies result from the hydrogen-bonds fluctuations, as evidenced by studies for supercooled water. However, it is difficult to characterize these fluctuations under ambient conditions. Here, we fill this knowledge gap thanks to the Car-Parrinello ab initio molecular dynamics (MD) simulation technique. We calculate the local structural order parameter ζ, quantifying the coordination shells separation, and find two locally-favored structures or states: High-ζ and Low-ζ. On average, High-ζ molecules have a tetrahedral arrangement, with four hydrogen bonds, and the first and the second coordination shell well separated. The Low-ζ molecules are less connected, partially merging the first and the second shells. The appearance of isosbestic points in the radial distribution functions and the collective density fluctuations at different length scales and timescales reveal that the two-state model, consistent with available experimental data for supercooled water, also holds under ambient conditions, as we confirm by analyzing the vibrational spectrum of both types of water molecules. Significant consequences of the structural differences between the two states are that High-ζ molecules have a dipole moment 6 % higher than Low-ζ. At the same time, Low-ζ structures are more disordered and with more significant angular fluctuations. These differences are also reflected in the dynamics under ambient conditions. The Low-ζ molecules decorrelate their reorientation faster than High-ζ and merge their coordination shells within 0.2 ps, while the High-ζ preserve the shell separation for longer times.
description: Added references in Section 3.3, added Figure 6, updated figures 1, 4, and 7
Search for associations containing young stars (SACY). VI. Is multiplicity universal? Stellar multiplicity in the range 3-1000 au from adaptive-optics observations
Creators: name: Elliott, P.
name: Huelamo, N.
name: Bouy, H.
name: Bayo, A.
name: Melo, C. H. F.
name: Torres, C. A. O.
name: Sterzik, M. F.
name: Quast, G. R.
name: Chauvin, G.
name: Barrado, D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Context. Young loose nearby associations are unique samples of close (<150 pc), young (approx 5-100 Myr) pre-main sequence (PMS) stars. A significant number of members of these associations have been identified in the SACY collaboration. We can use the proximity and youth of these members to investigate key ingredients in star formation processes, such as multiplicity. Aims. We present the statistics of identified multiple systems from 113 confirmed SACY members. We derive multiplicity frequencies, mass-ratio, and physical separation distributions in a consistent parameter space, and compare our results to other PMS populations and the field. Methods. We have obtained adaptive-optics assisted near-infrared observations with NACO (ESO/VLT) and IRCAL (Lick Observatory) for at least one epoch of all 113 SACY members. We have identified multiple systems using co-moving proper-motion analysis and using contamination estimates. We have explored ranges in projected separation and mass-ratio of a [3-1000 au], and q [0.1-1], respectively. Results. We have identified 31 multiple systems (28 binaries and 3 triples). We derive a multiplicity frequency (MF) of MF_(3-1000au)=28.4 +4.7, -3.9% and a triple frequency (TF) of TF_(3-1000au)=2.8 +2.5, -0.8% in the separation range of 3-1000 au. We do not find any evidence for an increase in the MF with primary mass. The estimated mass-ratio of our statistical sample (with power-law index gamma=-0.04 +/- 0.14) is consistent with a flat distribution (gamma = 0). Conclusions. We show further similarities (but also hints of discrepancies) between SACY and the Taurus region: flat mass-ratio distributions and statistically similar MF and TF values. We also compared the SACY sample to the field (in the separation range of 19-100 au), finding that the two distributions are indistinguishable, suggesting a similar formation mechanism.
description: 16 Pages, accepted in A&A 28 May 2015
(3149) Leslie Marianne Steele
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
[Kindle] EL LADRÓN DE ORQUÍDEAS descargar gratis
Creators: name: Clayson
Publisher: name: Zenodo
Year: 2024

description: EL LADRÓN DE ORQUÍDEAS de SUSAN ORLEAN

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EL LADRÓN DE ORQUÍDEAS

SUSAN ORLEAN

Número de páginas: 311

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788433940353

Editorial: ANAGRAMA

Año de edición: 2019

 

 

 

 

 

Descargas de audiolibros gratis reproductores de mp3 EL LADRÓN DE ORQUÍDEAS de SUSAN ORLEAN 9788433940353 FB2

 

Overview

La fascinación por las orquídeas viene de muy lejos. En la Inglaterra victoriana, llamaron «orquidelirio» a la locura por estas flores, una pasión equivalente a la «fiebre del oro». Los ricos coleccionistas de la época enviaban expediciones armadas a explorar territorios ignotos en busca de nuevos ejemplares, y la rivalidad entre ellas era tan feroz que terminaba en violentas batallas.La fascinación por las orquídeas viene de muy lejos. En la Inglaterra victoriana, llamaron «orquidelirio» a la locura por estas flores, una pasión equivalente a la «fiebre del oro». Los ricos coleccionistas de la época enviaban expediciones armadas a explorar territorios ignotos en busca de nuevos ejemplares, y la rivalidad entre ellas era tan feroz que terminaba en violentas batallas.En esta hipnótica historia real sobre la obsesión y la belleza, el bucanero a la caza, el ladrón de orquídeas de nuestros días, es John Laroche, un sujeto al borde de la legalidad, que está acusado, junto con tres indios seminolas, de robar especies protegidas en los pantanos de la reserva india de Fakahatchee (Florida).Pero este libro es mucho más que la historia de Laroche y sus hazañas. Su autora se ha sumergido en un mundo pantanoso, lleno de personajes ambiguos y complejos. Quizá porque la orquídea es también la más enigmática de las flores: es considerada el símbolo de las mujeres fatales, de la feminidad, pero su nombre viene del griego «orchid», «testículos»...
The Hubble Space Telescope UV Legacy Survey of Galactic Globular Clusters. IV. Helium content and relative age of multiple stellar populations within NGC 6352
Creators: name: Nardiello, D.
name: Piotto, G.
name: Milone, A. P.
name: Marino, A. F.
name: Bedin, L. R.
name: Anderson, J.
name: Aparicio, A.
name: Bellini, A.
name: Cassisi, S.
name: D'Antona, F.
name: Hidalgo, S.
name: Ortolani, S.
name: Pietrinferni, A.
name: Renzini, A.
name: Salaris, M.
name: van der Marel, R. P.
name: Vesperini, E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: In this paper we combine WFC3/UVIS F275W, F336W, and F438W data from the "UV Legacy Survey of Galactic Globular Clusters: Shedding Light on Their Populations and Formation" (GO-13297) HST Treasury program with F606W, F625W, F658N, and F814W ACS archive data for a multi-wavelength study of the globular cluster NGC 6352. In the color-magnitude and two-color diagrams obtained with appropriate combination of the photometry in the different bands we separate two distinct stellar populations and trace them from the main sequence to the subgiant, red giant, horizontal and asymptotic giant branches. We infer that the two populations differ in He by Delta Y=0.029+/-0.006. With a new method, we also estimate the age difference between the two sequences. Assuming no difference in [Fe/H] and [alpha/Fe], and the uncertainties on Delta Y, we found a difference in age between the two populations of 10+/-120 Myr. If we assume [Fe/H] and [alpha/Fe] differences of 0.02 dex (well within the uncertainties of spectroscopic measurements), the total uncertainty in the relative age rises to ~300 Myr.
description: 12 pages, 6 figures (3 at low resolution), 3 tables. Accepted for publication in MNRAS on April 29, 2015
ALITER DULCIA. PASTELES CON HISTORIA ISABEL PEREZ SARDIÑA ePub gratis
Creators: name: Payton
Publisher: name: Zenodo
Year: 2024

description: ALITER DULCIA. PASTELES CON HISTORIA de ISABEL PEREZ SARDIÑA

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Ficha técnica

ALITER DULCIA. PASTELES CON HISTORIA

ISABEL PEREZ SARDIÑA

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788419483461

Editorial: COL&COL EDICIONES

Año de edición: 2023

 

 

 

 

 

Descarga gratuita de la computadora del libro ALITER DULCIA. PASTELES CON HISTORIA

 

Overview

Una edición especial, ampliada y actualizada, del exitoso libro de Isabel Pérez, Aliter Dulcia - Pasteles con historia. Aliter Dulcia regresa con una edición especial de su libro Pasteles con historia, celebrando así el quinto aniversario de uno de sus títulos más exitosos. Tartas, magdalenas, galletas, cheesecakes, pasteles y sus imprescindibles bizcochos se reúnen de nuevo en este libro en el que comparte 100 de sus mejores recetas y donde une a la perfección sofisticación y creatividad. Isabel Pérez mantiene intacta al tiempo su repostería elegante y tradicional, combinando las recetas más elaboradas con creaciones sencillas que el lector podrá recrear en su propio hogar. Siempre desde una perspectiva personal y cercana, la repostera e influencer gastronómica plasma en estas páginas un recorrido a través de la familia, la historia, los viajes y, por supuesto, su gran proyecto: Aliter Dulcia. A esta edición especial se suman nuevas recetas, historias y consejos para que el lector se convierta en un auténtico maestro pastelero. Entre las novedades, destacan masas levadas, como el pan de chocolate y su particular versión de los cinnamon rolls, y otras recetas exquisitas como el gajar barfi. Cómo no, no faltan recetas en torno a las elaboraciones que más le apasionan: galletas rellenas de crema de limón, tarta esterházy, croissant bicolor... Un libro único para recrear la repostería y los postres más especiales de Aliter Dulcia.
Hypoxia Stress Test Reveals Exaggerated Cardiovascular Effects in Hypertensive Rats After Exposure to the Air Pollutant Acrolein
Creators: name: Costa, Daniel L.
name: Carll, Alex P.
name: Hazari, Mehdi S.
name: Perez, Christina M.
name: Ledbetter, Allen D.
name: Farraj, Aimen K.
name: Haykal-coates, Najwa
name: Winsett, Darrell W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Exposure to air pollution increases the risk of cardiovascular morbidity and mortality, especially in susceptible populations. Despite increased risk, adverse responses are often delayed and require additional stress tests to reveal latent effects of exposure. The goal of this study was to use an episode of “transient hypoxia” as an extrinsic stressor to uncover latent susceptibility to environmental pollutants in a rodent model of hypertension. We hypothesized that exposure to acrolein, an unsaturated aldehyde and mucosal irritant found in cigarette smoke, diesel exhaust, and power plant emissions, would increase cardiopulmonary sensitivity to hypoxia, particularly in hypertensive rats. Spontaneously hypertensive and Wistar Kyoto (normotensive) rats, implanted with radiotelemeters, were exposed once for 3h to 3 ppm acrolein gas or filtered air in whole-body plethysmograph chambers and challenged with a 10% oxygen atmosphere (10min) 24h later. Acrolein exposure increased heart rate, blood pressure, breathing frequency, and minute volume in hypertensive rats and also increased the heart rate variability parameter LF, suggesting a potential role for increased sympathetic tone. Normotensive rats only had increased blood pressure during acrolein exposure. The hypoxia stress test after acrolein exposure revealed increased diastolic blood pressure only in hypertensive rats and increased minute volume and expiratory time only in normotensive rats. These results suggest that hypertension confers exaggerated sensitivity to air pollution and that the hypoxia stress test is a novel tool to reveal the potential latent effects of air pollution exposure.
Quantum homomorphic encryption from quantum codes
Creators: name: Ouyang, Yingkai
name: Tan, Si-Hui
name: Fitzsimons, Joseph
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The recent discovery of fully-homomorphic classical encryption schemes has had a dramatic effect on the direction of modern cryptography. Such schemes, however, implicitly rely on the assumptions that solving certain computation problems are intractable. Here we present a quantum encryption scheme which is homomorphic for arbitrary classical and quantum circuits which have at most some constant number of non-Clifford gates. Unlike classical schemes, the security of the scheme we present is information theoretic and hence independent of the computational power of an adversary.
description: 8 pages, double column, 3 figures, strengthened security proof
Hyperonization in compact stars
Creators: name: Sedrakian, Armen
name: Li, Jia-Jie
name: Weber, Fridolin
Publisher: name: arXiv
Year: 2021
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We review the covariant density functional approach to the equation of state of the dense nuclear matter in compact stars. The main emphasis is on the hyperonization of the dense matter, and the role played by the $Δ$-resonances. The implications of hyperonization for the astrophysics of compact stars, including the equation of state, composition, and stellar parameters are examined. The mass-radius relation and tidal deformabilities of static and rapidly rotating (Keplerian) configurations are discussed in some detail. We briefly touch upon some other recent developments involving hyperonization in hot hypernuclear matter at high- and low-densities.
description: v3: matches final version, references updated; v2: 47 pages, 11 figures, minor corrections; v1: 45 pages, 11 figures, chapter to appear in "Astrophysics in the XXI century with compact stars", World Scientific, eds. Cesar Zen Vasconcellos and Fridolin Weber
Identification of Hepatic Phospholipidosis Inducers in Sandwich-Cultured Rat Hepatocytes, a Physiologically Relevant Model, Reveals Altered Basolateral Uptake and Biliary Excretion of Anionic Probe Substrates
Creators: name: Brouwer, Kim L.R.
name: Ferslew, Brian C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Drug-induced phospholipidosis (PLD) is characterized by phospholipid accumulation within the lysosomes of affected tissues, resulting in lysosomal enlargement and laminar body inclusions. Numerous adverse effects and toxicities have been linked to PLD-inducing drugs, but it remains unknown whether drug-induced PLD represents a distinct toxicity or cellular adaptation. In silico and immortalized cellular models have been used to evaluate the PLD potential of new drugs, but these systems have some limitations. The aims of this study were to determine whether primary sandwich-cultured hepatocytes (SCH) can serve as a sensitive and selective model to evaluate hepatic drug-induced PLD, and to evaluate the impact of PLD on the uptake and biliary excretion of probe substrates, taurocholate (TC) and rosuvastatin (RSV). Rat SCH were cultured for 48 h with prototypic hepatic PLD-inducing drugs, amiodarone (AMD), chloroquine (CHQ), desipramine (DES), and azithromycin (AZI), as well as the renal PLD inducer gentamicin (GTM). LysoTracker Red localization and transmission electron microscopy indicated enlarged lysosomal compartments and laminar body inclusions in SCH treated with AMD, CHQ, DES, and AZI, but not GTM, relative to control. PLD resulted in a 51–92% decrease in the in vitro biliary clearance of both TC and RSV; the biliary excretion index significantly decreased for TC from 88 to 35–73%. These data suggested that PLD significantly reduced both organic anion transporting polypeptide-mediated uptake, and bile salt export pump-mediated biliary transport processes. The current study demonstrates that the rat SCH system is a promising model to study hepatic PLD in vitro. Altered hepatic transport of anionic substrates secondary to drug-induced PLD is a novel finding.
The Holographic Entropy Cone
Creators: name: Bao, Ning
name: Nezami, Sepehr
name: Ooguri, Hirosi
name: Stoica, Bogdan
name: Sully, James
name: Walter, Michael
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We initiate a systematic enumeration and classification of entropy inequalities satisfied by the Ryu-Takayanagi formula for conformal field theory states with smooth holographic dual geometries. For 2, 3, and 4 regions, we prove that the strong subadditivity and the monogamy of mutual information give the complete set of inequalities. This is in contrast to the situation for generic quantum systems, where a complete set of entropy inequalities is not known for 4 or more regions. We also find an infinite new family of inequalities applicable to 5 or more regions. The set of all holographic entropy inequalities bounds the phase space of Ryu-Takayanagi entropies, defining the holographic entropy cone. We characterize this entropy cone by reducing geometries to minimal graph models that encode the possible cutting and gluing relations of minimal surfaces. We find that, for a fixed number of regions, there are only finitely many independent entropy inequalities. To establish new holographic entropy inequalities, we introduce a combinatorial proof technique that may also be of independent interest in Riemannian geometry and graph theory.
description: 48 pages, 14 figures
Trace formulas for Schrödinger operators on periodic graphs
Creators: name: Korotyaev, Evgeny
name: Saburova, Natalia
Publisher: name: arXiv
Year: 2021
Subjects: subject: Spectral Theory (math.SP)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We consider Schrödinger operators with periodic potentials on periodic discrete graphs. Their spectrum consists of a finite number of bands. We determine trace formulas for the Schrödinger operators. The proof is based on the decomposition of the Schrödinger operators into a direct integral and a specific representation of fiber operators. The traces of the fiber operators are expressed as finite Fourier series of the quasimomentum. The coefficients of the Fourier series are given in terms of the potentials and cycles in the quotient graph from some specific cycle sets. We also present the trace formulas for the heat kernel and the resolvent of the Schrödinger operators and the determinant formulas.
description: 33 pages, 3 figures
Wide-Range Tunable Dynamic Property of Carbon Nanotube-Based Fibers
Creators: name: Zhao, Jingna
name: Zhang, Xiaohua
name: Pan, Zhijuan
name: Li, Qingwen
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Carbon nanotube (CNT) fiber is formed by assembling millions of individual tubes. The assembly feature provides the fiber with rich interface structures and thus various ways of energy dissipation, as reflected by the non-zero loss tangent (>0.028--0.045) at low vibration frequencies. A fiber containing entangled CNTs possesses higher loss tangents than a fiber spun from aligned CNTs. Liquid densification and polymer infiltration, the two common ways to increase the interfacial friction and thus the fiber's tensile strength and modulus, are found to efficiently reduce the damping coefficient. This is because the sliding tendency between CNT bundles can also be well suppressed by the high packing density and the formation of covalent polymer cross-links within the fiber. The CNT/bismaleimide composite fiber exhibited the smallest loss tangent, nearly as the same as that of carbon fibers. At a higher level of the assembly structure, namely a multi-ply CNT yarn, the inter-fiber friction and sliding tendency obviously influence the yarn's damping performance, and the loss tangent can be tuned within a wide range, as similar to carbon fibers, nylon yarns, or cotton yarns. The wide-range tunable dynamic properties allow new applications ranging from high quality factor materials to dissipative systems.
Supplementary Table 7 from Taxonomy assignment approach determines the efficiency of identification of OTUs in marine nematodes
Creators: name: Holovachov, Oleksandr
name: Haenel, Quiterie
name: Bourlat, Sarah J.
name: Jondelius, Ulf
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60301 Animal Systematics and Taxonomy
subject: 60310 Plant Systematics and Taxonomy

description: Results of phylogeny-based taxonomy assignment using mothur and PaPaRa-based alignments.
Semi-Supervised Hierarchical Graph Classification
Creators: name: Li, Jia
name: Huang, Yongfeng
name: Chang, Heng
name: Rong, Yu
Publisher: name: arXiv
Year: 2022
Subjects: subject: Social and Information Networks (cs.SI)
subject: Artificial Intelligence (cs.AI)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Node classification and graph classification are two graph learning problems that predict the class label of a node and the class label of a graph respectively. A node of a graph usually represents a real-world entity, e.g., a user in a social network, or a document in a document citation network. In this work, we consider a more challenging but practically useful setting, in which a node itself is a graph instance. This leads to a hierarchical graph perspective which arises in many domains such as social network, biological network and document collection. We study the node classification problem in the hierarchical graph where a 'node' is a graph instance. As labels are usually limited, we design a novel semi-supervised solution named SEAL-CI. SEAL-CI adopts an iterative framework that takes turns to update two modules, one working at the graph instance level and the other at the hierarchical graph level. To enforce a consistency among different levels of hierarchical graph, we propose the Hierarchical Graph Mutual Information (HGMI) and further present a way to compute HGMI with theoretical guarantee. We demonstrate the effectiveness of this hierarchical graph modeling and the proposed SEAL-CI method on text and social network data.
description: Accepted by TPAMI. Journal extension of arXiv:1904.05003
(3152) Charles Edward Medhurst
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Progress in Assessing Air Pollutant Risks from In Vitro Exposures: Matching Ozone Dose and Effect in Human Airway Cells
Creators: name: Devlin, Robert B.
name: Diaz-Sanchez, David
name: Carraway, Martha Sue
name: Schmitt, Michael T.
name: Hatch, Gary E.
name: Berntsen, Jon
name: Ghio, Andrew J.
name: Dailey, L. A.
name: McKee, John
name: Duncan, Kelly E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: In vitro exposures to air pollutants could, in theory, facilitate a rapid and detailed assessment of molecular mechanisms of toxicity. However, it is difficult to ensure that the dose of a gaseous pollutant to cells in tissue culture is similar to that of the same cells during in vivo exposure of a living person. The goal of the present study was to compare the dose and effect of O3 in airway cells of humans exposed in vivo to that of human cells exposed in vitro. Ten subjects breathed labeled O3 (18O3, 0.3 ppm, 2 h) while exercising intermittently. Bronchial brush biopsies and lung lavage fluids were collected 1 h post exposure for in vivo data whereas in vitro data were obtained from primary cultures of human bronchial epithelial cells exposed to 0.25–1.0 ppm 18O3 for 2 h. The O3 dose to the cells was defined as the level of 18O incorporation and the O3 effect as the fold increase in expression of inflammatory marker genes (IL-8 and COX-2). Dose and effect in cells removed from in vivo exposed subjects were lower than in cells exposed to the same 18O3 concentration in vitro suggesting upper airway O3 scrubbing in vivo. Cells collected by lavage as well as previous studies in monkeys show that cells deeper in the lung receive a higher O3 dose than cells in the bronchus. We conclude that the methods used herein show promise for replicating and comparing the in vivo dose and effect of O3 in an in vitro system.
Self-consistent theory of a homogeneous binary Bose mixture with strong repulsive interspecies interaction
Creators: name: Rakhimov, Abdulla
name: Abdurakhmonov, Tolibjon
name: Narzikulov, Zabardast
name: Yukalov, Vyacheslav I.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: Multicomponent quantum gases are ideal platforms to study fundamental phenomena arising from the mutual interaction between different constituents. Particularly, due to the repulsive interactions between two species, the system may exhibit a phase separation. We develop a mean-field-based theory for a two-component Bose mixture, which is equivalent to the Hartree-Fock-Bogoliubov approximation, and derive analytical expressions for the phase boundary and miscibility. The majority of existing theories, which are valid only for weakly interacting Bose gases, predict that the phase boundary is determined by the criterion $g_{ab}\leqslant\sqrt{g_{aa} g_{bb}}$ (where $g_{ab}$ is a coupling constant between the components $a$ and $b$). We show that in the Bose-Einstein-condensation phase ($T\leqslant T_c$) the system may remain in a stable and miscible phase also for larger values of $g_{ab}$, depending on the gas parameter $γ$ and temperature.
description: Revised version. 34 pages, 14 figures
Scalars are universal: Equivariant machine learning, structured like classical physics
Creators: name: Villar, Soledad
name: Hogg, David W.
name: Storey-Fisher, Kate
name: Yao, Weichi
name: Blum-Smith, Ben
Publisher: name: arXiv
Year: 2021
Subjects: subject: Machine Learning (cs.LG)
subject: Mathematical Physics (math-ph)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: There has been enormous progress in the last few years in designing neural networks that respect the fundamental symmetries and coordinate freedoms of physical law. Some of these frameworks make use of irreducible representations, some make use of high-order tensor objects, and some apply symmetry-enforcing constraints. Different physical laws obey different combinations of fundamental symmetries, but a large fraction (possibly all) of classical physics is equivariant to translation, rotation, reflection (parity), boost (relativity), and permutations. Here we show that it is simple to parameterize universally approximating polynomial functions that are equivariant under these symmetries, or under the Euclidean, Lorentz, and Poincaré groups, at any dimensionality $d$. The key observation is that nonlinear O($d$)-equivariant (and related-group-equivariant) functions can be universally expressed in terms of a lightweight collection of scalars -- scalar products and scalar contractions of the scalar, vector, and tensor inputs. We complement our theory with numerical examples that show that the scalar-based method is simple, efficient, and scalable.
description: NeurIPS 2021
(3153) Francis Amelia Moore
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Integrated copy number and gene expression analysis detects a CREB1 association with Alzheimer’s disease
Creators: name: Li, Y.
name: Shaw, C. A.
name: Wilhelmsen, K. C.
name: Sule, N.
name: Powell, S. Z.
name: Sheffer, I.
name: Szigeti, K.
name: Bucasas, K. L.
name: Zaidi, S. N.Y.
name: Doody, R.
name: Lupski, J. R.
name: Dawson, B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Genetic variation, both single-nucleotide variations and copy number variations (CNV), contribute to changes in gene expression. In some cases these variations are meaningfully correlated with disease states. We hypothesized that in a genetically heterogeneous disorder such as sporadic Alzheimer's disease (AD), utilizing gene expression as a quantitative trait and CNVs as a genetic marker map within the same individuals in the context of case–control status may increase the power to detect relevant loci. Using this approach an 8-kb deletion was identified that contains a PAX6-binding site on chr2q33.3 upstream of CREB1 encoding the cAMP responsive element-binding protein1 transcription factor. The association of the CNV to AD was confirmed by a case–control association study consisting of the Texas Alzheimer Research and Care Consortium and NIA-LOAD Family Study data sets.
The global build-up to intrinsic ELM bursts seen in divertor full flux loops in Jet
Creators: name: Chapman, S. C.
name: Dendy, R. O.
name: Todd, T. N.
name: Watkins, N. W.
name: Calderon, F. A.
name: Morris, J.
name: Contributors, JET
Publisher: name: arXiv
Year: 2015
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: A global signature of the build-up to an intrinsic ELM is found in the phase of signals measured in full flux azimuthal loops in the divertor region of JET. Full flux loop signals provide a global measurement proportional to the voltage induced by changes in poloidal magnetic flux; they are electromagnetically induced by the dynamics of spatially integrated current density. We perform direct time-domain analysis of the high time-resolution full flux loop signals VLD2 and VLD3. We analyze plasmas where a steady H-mode is sustained over several seconds, during which all the observed ELMs are intrinsic; there is no deliberate intent to pace the ELMing process by external means. ELM occurrence times are determined from the Be II emission at the divertor. We previously found that the occurrence times of intrinsic ELMs correlate with specific phases of the VLD2 and VLD3 signals. Here, we investigate how the VLD2 and VLD3 phases vary with time in advance of the ELM occurrence time. We identify a build-up to the ELM in which the VLD2 and VLD3 signals progressively align to the phase at which ELMs preferentially occur, on a ~ 2 -5ms timescale. At the same time, the VLD2 and VLD3 signals become phase synchronized with each other, consistent with the emergence of coherent global dynamics in the integrated current density. In a plasma that remains close to a global magnetic equilibrium, this can reflect bulk displacement or motion of the plasma. This build-up signature to an intrinsic ELM can be extracted from a time interval of data that does not extend beyond the ELM occurrence time, so that these full flux loop signals could assist in ELM prediction or mitigation.
description: 31 pages, 13 figures. The following article has been submitted to Physics of Plasmas. After it is published it will be found at http://scitation.aip.org/content/aip/journal/pop/browse
PDF [DOWNLOAD] Sweet Nightmare (Deluxe Limited Edition) by Tracy Wolff on Iphone
Creators: name: Palmer
Publisher: name: Zenodo
Year: 2024

description: Sweet Nightmare (Deluxe Limited Edition) by Tracy Wolff

 

 

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Sweet Nightmare (Deluxe Limited Edition)

Tracy Wolff

Page: 496

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ISBN: 9781649377012

Publisher: Entangled Publishing, LLC

 

Kindle free e-book Sweet Nightmare (Deluxe Limited Edition) (English Edition) by Tracy Wolff

Overview

Notes From Your Bookseller Revisit a swirl of fae, werewolves and more at The Calder Academy in a deluxe and limited edition of the first installment of the fabulous series from Tracy Wolff. Preorder now and receive the stunning DELUXE LIMITED EDITION while supplies last―featuring gorgeous sprayed edges, as well as exclusive special design features. This breathtaking collectible is only available on a limited first print run, a must-have for any book lover while supplies last in the US and Canada only. The scariest school on earth Is about to experience real fear… Most schools are about being the best. This school? It’s about being the worst. Calder Academy is where the rogue paranormals go. The ones who break the rules or lose control. And when that happens for vamps, werewolves, witches, and dark fae? It gets pretty freaking scary. I should know. Because I’m trapped here. Look, every seventeen-year-old girl thinks their mom is a tyrant. But mine just happens to run Calder Academy, which paints a giant target on my back. The way I make it through these dark halls is by steering clear of the things—and kids—who go bump in the night. Especially Jude Abernathy-Lee. But when a freak storm hits our isolated island, I'm stuck without a backup plan. The power is gone. The lights are out. And our worst nightmares are suddenly real—and out for blood. Now the only way to survive is to align myself with one evil to avoid the other. And the only thing worse than the idea of getting close to Jude? Secretly loving every minute of it. The Calder Academy series is best enjoyed in order. Reading Order: Book #1 Sweet Nightmare Book #2 Sweet Chaos Book #3 Sweet Vengeance