cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Evaluating local capacity for climate change adaptation and disaster risk reduction : the case of Pulilan Bulacan, Philippines
Creators: name: Brown, Christa Louise
Publisher: name: The University of British Columbia
Year: 2015

description: Climate change is often discussed as something that will happen in the future. However, in many places around the world such as the Philippines, extreme weather events and changing weather patterns that may be attributed to climate change are already occurring and the destructive impacts are very real for communities that are exposed and vulnerable to natural hazards. Climate Change Adaptation (CCA) and Disaster Risk Reduction (DRR) are now commonly viewed as interrelated policy areas, linked together through a shared focus on weather and climate, and with many overlapping objectives. Both complex issues in their own right and rife with uncertainty, CCA and DRR create new challenges for planning, policy formulation, decision making, and implementation. In the Philippines, authority has been delegated to Local Government Units (LGUs) – provinces, cities and municipalities, and barangays – for the implementation and maintenance of both climate change and disaster risk reduction programs. It is therefore essential to ensure that LGUs tasked with planning for climate change adaptation and associated hazard mitigation possess the capacity required to do so. This project utilizes an asset-based approach to evaluate the local capacity for CCA and DRR of one LGU within the Angat Watershed, the Municipality of Pulilan. Drawing from Appreciative Inquiry – an action research methodology that not only allows for better understanding and appreciation of current capacity, but can also provide for the possibility of innovative transformation to occur within an organization – it focuses on the existing strengths and past successes of the Municipality in order to assess existing adaptive capacity. Adaptive capacity is the ability of a system or community to cope with, prepare for, avoid, or recover from the exposure to the effects of climate change. High adaptive capacity reduces the vulnerability of a community by serving as a counterweight to the community’s exposure and sensitivity to climate change impacts and associated hazards.
Tissue remodelling in the colonic wall of patients with ulcerative colitis
Creators: name: Ippolito, Chiara
name: Segnani, Cristina
name: Dini, Sauro
name: Battolla, Barbara
name: Castagna, Maura
name: Buccianti, Piero
name: Dolfi, Amelio
name: Bernardini, Nunzia
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2013
Subjects: Fibrotic remodelling; neoangiogenesis; immunohistochemistry; ulcerative colitis

description: Inflammation-driven tissue remodelling may develop to fibrotic rearrangement. With regard to inflammatory bowel diseases, fibrotic remodelling has been evaluated in Crohn’s disease, while little attention to such processes has been paid to ulcerative colitis (UC) [1]. The present study evaluated the distribution of connective tissue and angiogenesis in colon of patients with UC, paying particular attention to the tonaca muscularis, which is poorly considered in histopathological studies. Full-thickness left colonic samples were obtained from 10 patients with established, severe and pharmacologically unresponsive UC, who underwent bowel resection. Routine histology, histochemistry and immunohistochemistry were conducted in paraffin cross-sections. The distribution of collagen and elastic fibers was evaluated and quantified by both histochemical (Van Gieson, orcein, Verroheff staining) and immunohistochemical (anti-collagen I and III, anti-elastin) assays. The vascular network pattern was studied by anti-CD31 and nestin immunostaining. For comparison, the same evaluations were performed in healthy colonic control samples obtained from 10 subjects, who underwent surgery for uncomplicated colon cancer. A significant increase in collagen fibers and a decrease in elastin content were detected in the UC inflamed colon, as compared with controls. In particular, enhanced collagen deposition (mainly collagen type III) were found at level of submucosa, and tonaca muscularis within the longitudinal muscle (mainly along the serosal side) and circular muscle layer, and in perivascular connective tissue. By contrast, elastic fibers were significantly reduced throughout the whole muscle compartment, with particular regard for the myenteric ridge. Microvessel density was significantly higher in both submucosa and tonaca muscularis of colonic samples from UC patients compared with those from healthy control individuals. The present findings indicate that a significant tissue remodelling occurs in the inflamed colonic wall in patients with UC, also at the level of muscle layers. This rearrangement of the connective fibers and vascular network, together with the known alterations affecting the myenteric neurons and interstitial cells of Cajal, may contribute to the development of enteric dysmotility, and, accordingly, to the serious digestive symptoms which afflict patients with UC.
description: Italian Journal of Anatomy and Embryology, Vol 117, No 2 (Supplement) 2012
title: Ð¡Ð¸ÑÑÐµÐ¼Ð° ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ ÐºÐ¾Ð²Ð¾ÑÐ½ÑÐ¼ Ð¼Ð¾Ð»Ð¾ÑÐ¾Ð¼
title: Ð´Ð¸Ð¿Ð»Ð¾Ð¼Ð½ÑÐ¹ Ð¿ÑÐ¾ÐµÐºÑ
titleType: Subtitle
Creators: name: ÐÐ¾ÑÐ¸ÑÐµÐ½ÐºÐ¾, ÐÐ»Ð°Ð´Ð¸Ð¼Ð¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2016
Subjects: ÑÑÐ½Ð´Ð°Ð¼ÐµÐ½ÑÐ½ÑÐ¹ Ð±Ð»Ð¾Ðº
ÑÐ°Ð±Ð¾Ñ
ÑÑÐ½Ð´Ð°Ð¼ÐµÐ½ÑÐ½ÑÐµ Ð¾Ð¿Ð¾ÑÑ

description: Ð¡ ÑÐµÐ»ÑÑ ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸Ð¸ Ð¼ÐµÑÐ°Ð»Ð° Ð² Ð¼Ð°ÑÐ¸Ð½Ð¾ÑÑÑÐ¾ÐµÐ½Ð¸Ð¸ ÑÐ°Ð¼Ð¾Ðµ ÑÐ¸ÑÐ¾ÐºÐ¾Ðµ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ðµ Ð½Ð°ÑÐ»Ð¸ Ð¿ÑÐ¾ÑÐµÑÑÑ ÑÐ²Ð¾Ð±Ð¾Ð´Ð½Ð¾Ð¹ ÐºÐ¾Ð²ÐºÐ¸ Ð¿ÑÐ¸ Ð¿Ð¾Ð¼Ð¾ÑÐ¸ ÐºÐ¾Ð²Ð¾ÑÐ½ÑÑ Ð¼Ð¾Ð»Ð¾ÑÐ¾Ð² Ð´Ð²Ð¾Ð¹Ð½Ð¾Ð³Ð¾ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ. ÐÑÐ¾ÑÐµÑÑÑ ÑÐ²Ð¾Ð±Ð¾Ð´Ð½Ð¾Ð¹ ÐºÐ¾Ð²ÐºÐ¸ Ð¾ÐºÐ°Ð·ÑÐ²Ð°ÑÑ Ð¿ÐµÑÐ¸Ð¾Ð´Ð¸ÑÐµÑÐºÐ¾Ðµ ÑÐ¸Ð»Ð¾Ð²Ð¾Ðµ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ Ð½Ð° Ð¾Ð±ÑÐ°Ð±Ð°ÑÑÐ²Ð°ÐµÐ¼ÑÑ Ð¿Ð¾ÐºÐ¾Ð²ÐºÑ, ÑÑÐ¾ Ð¼Ð¾Ð¶ÐµÑ Ð²ÑÐ·Ð²Ð°ÑÑ Ð½ÐµÐ¶ÐµÐ»Ð°ÑÐµÐ»ÑÐ½ÑÐµ ÑÐµÐ·Ð¾Ð½Ð°Ð½ÑÐ½ÑÐµ ÑÐ²Ð»ÐµÐ½Ð¸Ñ Ð² ÑÐ¸ÑÑÐµÐ¼Ðµ ÑÐ°Ð±Ð¾Ñ - ÑÑÐ½Ð´Ð°Ð¼ÐµÐ½Ñ. ÐÐ¾ÑÑÐ¾Ð¼Ñ, Ð²ÑÐ±Ð¾Ñ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¿ÑÐ¾ÑÐµÑÑÐ° Ð´Ð¾Ð»Ð¶ÐµÐ½ Ð±ÑÑÑ ÑÐ²ÑÐ·Ð°Ð½ Ñ ÐºÐ¾ÑÑÐµÐ»ÑÑÐ¸ÐµÐ¹ ÑÐ°ÑÑÐ¾ÑÑ ÑÐ¸Ð»Ð¾Ð²Ð¾Ð³Ð¾ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð¿Ð°Ð´Ð°ÑÑÐµÐ¹ Ð±Ð°Ð±Ñ Ð¸ ÑÐ¾Ð±ÑÑÐ²ÐµÐ½Ð½ÑÐ¼Ð¸ ÑÐ°ÑÑÐ¾ÑÐ°Ð¼Ð¸ ÑÐ¸ÑÑÐµÐ¼Ñ ÑÐ°Ð±Ð¾Ñ - ÑÑÐ½Ð´Ð°Ð¼ÐµÐ½Ñ. ÐÑÐ¾Ð¸Ð·Ð²ÐµÐ´ÐµÐ½ Ð³Ð°ÑÐ¼Ð¾Ð½Ð¸ÑÐµÑÐºÐ¸Ð¹ Ð°Ð½Ð°Ð»Ð¸Ð· ÑÐ¸Ð»Ð¾Ð²Ð¾Ð³Ð¾ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð¿Ð°Ð´Ð°ÑÑÐµÐ¹ Ð±Ð°Ð±Ñ. Ð ÑÐ°Ð±Ð¾ÑÐµ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð¸Ð¸ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ñ ÐÐ°Ð³ÑÐ°Ð½Ð¶Ð° Ð±ÑÐ» ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½ Ð°Ð»Ð³Ð¾ÑÐ¸ÑÐ¼ Ð½Ð°ÑÐ¾Ð¶Ð´ÐµÐ½Ð¸Ñ ÑÐ¾Ð±ÑÑÐ²ÐµÐ½Ð½ÑÑ ÑÐ°ÑÑÐ¾Ñ ÑÐ¸ÑÑÐµÐ¼Ñ ÑÐ°Ð±Ð¾Ñ - ÑÑÐ½Ð´Ð°Ð¼ÐµÐ½Ñ, ÐºÐ¾ÑÐ¾ÑÑÐ¹ ÑÐµÐ°Ð»Ð¸Ð·Ð¾Ð²Ð°Ð½ Ð¿ÑÐ¸ Ð¿Ð¾Ð¼Ð¾ÑÐ¸ ÑÐ¸ÑÑÐµÐ¼Ñ MATHCAD.
Methods for the design and analysis of higher-order mode couplers applied to superconducting accelerating structures
Creators: name: Papke, Kai
Publisher: name: Universität Rostock
Year: 2020
Subjects: subject: 530 Physics
subject: 620 Engineering & allied operations
subject: 621.3 Electrical Engineering, Electronics

description: Higher-order modes (HOMs) may affect beam stability and refrigeration requirements of superconducting proton linacs such as the SPL which is being studied at CERN. One option being considered to limit these effects is the use of coaxial HOM couplers. In this work, potentially dangerous modes are analyzed and corresponding damping requirements derived. The design process of coaxial HOM couplers is examined under new aspects. Several prototypes are elaborated and compared in terms of mode damping, thermal loads, structural deformations, mechanical tolerances, and multipacting.
Stochastic background of gravitational waves generated by pre-galactic black holes
Creators: name: Pereira, Eduardo S.
name: Miranda, Oswaldo D.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: In this work, we consider the stochastic background of gravitational waves (SBGWs) produced by pre-galactic stars, which form black holes in scenarios of structure formation. The calculation is performed in the framework of hierarchical structure formation using a Press-Schechter-like formalism. Our model reproduces the observed star formation rate at redshifts z < 6.5. The signal predicted in this work is below the sensitivity of the first generation of detectors but could be detectable by the next generation of ground-based interferometers. Specifically, correlating two coincident advanced LIGO detectors (LIGO III interferometers), the expected signal-to-noise-ratio (S/N) could be as high as 90 (10) for stars forming at redshift z ~ 20 with a Salpeter initial mass function with slope x=0.35 (1.35), and if the efficiency of generation of gravitational waves is close to the maximum value ~ 7 x 10^{-4}. However, the sensitivity of the future third generation of detectors as, for example, the European antenna EGO could be high enough to produce (S/N)}>3 same with efficiency ~ 2 x 10^{-5}. We also discuss what astrophysical information could be derived from a positive (or even negative) detection of the SBGWs investigated here.
description: Accepted for publication in MNRAS (11 pages, 8 figures)
Role of physical activity program in the tertiary prevention of female breast cancer: a pilot study
Creators: name: Marini, Mirca
name: Mirandola, Daniela
name: Miccinesi, Guido
name: Muraca, Maria Grazia
name: Sgambati, Eleonora
name: Monaci, Marco
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2011
Subjects: physical activity; breast cancer; tertiary prevention

description: Physical activity is recognised internationally as a key factor in breast cancer prevention that is worldwide the major cause of cancer incidence and mortality in women. It is likely that physical activity is associated with decreased breast cancer risk via multiple interrelated biologic pathway that may involve adiposity, sex hormones, insulin resistence, adipokines and chronic inflammation (Recent Results Cancer Res, 2011). Although women diagnosed with breast cancer are living longer for treatment improvements, concerns about functional limitations, recurrence and survival remain paramount. Recent researches support the beneficial role that physical activity plays in reducing the risk for developing breast cancer and preventing or attenuating disease and treatment-related impairments (Methods Mol Biol, 2009). Post-diagnosis physical activity has been associated with improved quality of life and survivors should be encouraged to initiate and maintain a program of physical activity (Cancer Prev Res, 2011). However, actually it is not yet clear which duration, frequency and intensity of physical activities provide the benefits in primary or tertiary prevention; studies are also limited by incomplete reporting and methodological limitations (Cancer Treat Rev, 2010). We provided a physical activity program in breast cancer survivors (60 women; mean age 59,5 ± 9,8) recruited by Cancer Rehabilitation Center in Florence to investigate the role of physical activity on psychophysical wellness. The subjects were evaluated at the baseline and after the 8-week study period. The anthropometric parameters were measured and the subjects underwent a battery of fitness tests to assess shoulder-arm mobility and range of motion, and back flexibility. All partecipants filled out numerical rating scale and Short-Form 12 questionnaires to quantify the pain intensity to back and the shoulder of the operated arm, and to assess the quality of life, respectively. Our results demonstrated that an organized specific program of adapted physical activity may be an effective countermeasure to reduce the adverse effects after surgery and oncological therapy.
description: Italian Journal of Anatomy and Embryology, Vol 116, No 1 (Supplement) 2011
Additional file 2 of Comparison of the sex hormones’ serum level in women with recurrent aphthous stomatitis and healthy population: a cross-sectional study
Creators: name: Lavaee, Fatemeh
name: Ranjbar, Zahra
name: Jalalian, Mina
name: Amiri, Mohammad Amin
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: Additional file 2: Relationship of the evaluated hormones and age.
title: Ð£Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ðµ Ð´ÐµÐ±Ð¸ÑÐ¾ÑÑÐºÐ¾Ð¹ Ð·Ð°Ð´Ð¾Ð»Ð¶ÐµÐ½Ð½Ð¾ÑÑÑÑ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¸ (Ð½Ð° Ð¿ÑÐ¸Ð¼ÐµÑÐµ ÐÐÐ Â«ÐÐµÑÐµÑÐ±ÑÑÐ³Ð³Ð°Ð·Â»)
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
Creators: name: ÐÐ¾ÑÐ¾Ð·Ð¾Ð², ÐÐ°ÐºÑÐ¸Ð¼
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2018
Subjects: Ð´ÐµÐ±Ð¸ÑÐ¾ÑÑÐºÐ°Ñ Ð·Ð°Ð´Ð¾Ð»Ð¶ÐµÐ½Ð½Ð¾ÑÑÑ
ÑÐµÐºÐ¾Ð¼ÐµÐ½Ð´Ð°ÑÐ¸Ð¸ Ð¿Ð¾ ÑÐ»ÑÑÑÐµÐ½Ð¸Ñ
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ÑÐ°ÐºÑÐ¾ÑÐ¸Ð½Ð³

description: Ð¦ÐµÐ»ÑÑ Ð²ÑÐ¿ÑÑÐºÐ½Ð¾Ð¹ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ ÑÐ²Ð»ÑÐµÑÑÑ Ð°Ð½Ð°Ð»Ð¸Ð· Ð¸ Ð¾ÑÐµÐ½ÐºÐ° ÑÐ¸Ð½Ð°Ð½ÑÐ¾Ð²Ð¾Ð³Ð¾ Ð¿Ð¾Ð»Ð¾Ð¶ÐµÐ½Ð¸Ñ Ð³Ð¾ÑÑÐ´Ð°ÑÑÑÐ²ÐµÐ½Ð½Ð¾Ð³Ð¾ ÑÐ½Ð¸ÑÐ°ÑÐ½Ð¾Ð³Ð¾ Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ñ, Ð° ÑÐ°ÐºÐ¶Ðµ Ð¸Ð·ÑÑÐµÐ½Ð¸Ðµ Ð¸ Ð¿ÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ð¸Ðµ Ð¿ÑÑÐµÐ¹ ÑÐ»ÑÑÑÐµÐ½Ð¸Ñ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ Ð´ÐµÐ±Ð¸ÑÐ¾ÑÑÐºÐ¾Ð¹ Ð·Ð°Ð´Ð¾Ð»Ð¶ÐµÐ½Ð½Ð¾ÑÑÑÑ.
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Mitochondrial metabolism and morphology in a rat model of NAFLD
Creators: name: Solinas, Paola
name: Diana, Martina
name: Loy, Francesco
name: Isola, Michela
name: Isola, Raffaella
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2011
Subjects: mitochondria; NAFLD; OXPHOS

description: NAFLD (non-alcoholic fatty liver disease) is a condition, characterized by fatty liver, that, if untreated, can progress to NASH (non-alcoholic steatohepatitis) and, finally, to cirrhosis. Mitochondrial dysfunction is a crucial element for the progression of NAFLD to NASH. Our objective was studying both morphological and physiological mitochondrial alterations in a rat model of NAFLD and NASH. Sprague Dawley rats were fed either by a standard diet (35% of energy from fat) or by a high fat diet (HFD) (71% of energy from fat). Diets were given ad libitum for a maximum of four weeks and then rats were killed by decapitation after 1, 2, 3, and 4 weeks. A portion of liver samples was processed for light and transmission electron microscopy (TEM) for steatosis assessment, a part for high resolution scanning electron microscopy (HRSEM) to evaluate 3D mitochondria morphology, the remaining part for oxidative phosphorylation experiments (OXPHOS). Measurements of OXPHOS were performed on freshly isolated mitochondria in a Clark-type oxygen electrode. Several substrates were added to mitochondria to test the efficiency of electron transport chain complexes (ETC) and to test the efficiency of several enzymes involved in fatty acid oxidation (FAO). At three and four weeks of HFD, signs of hepatic steatosis were evident (as an increased amount of intracellular lipid droplets) on histological sections and TEM images. OXPHOS measurements indicated that, compared to controls, in the first week, HFD rats had an increased oxygen consumption with each substrate, in the second, third and fourth week OXPHOS efficiency had a tendency to decline with substrates inherent to glycolitic metabolism, but it was higher with substrates stimulating FAO. There were not notable differences in Respiratory Control Ratio and ADP/O ratio between HFD and controls, proving that the integrity of mitochondria was preserved and coupled to phosphorylation. HRSEM observations indicated that variations on inner mitochondrial morphology in HFD rats, appeared in the third and fourth week, when mitochondrial cristae were less, and cristal shape was often lamellar rather than tubular. Concluding, following HFD mitochondria exhibited first an increase in oxidative metabolism (with normal ultrastructural morphology) and later an alteration in the oxidative phosphorylation apparatus associated to mitochondrial cristae injury. These preliminary results suggest that in order to develop a consistent mitochondrial impairment associated to NASH is necessary to extend HFD treatment for longer.  This study was supported by a grant by RAS (Regione Autonoma della Sardegna).
description: Italian Journal of Anatomy and Embryology, Vol 116, No 1 (Supplement) 2011
A geometrical approach to the dynamics of spinor condensates I: Hydrodynamics
Creators: name: Barnett, Ryan
name: Podolsky, Daniel
name: Refael, Gil
Publisher: name: arXiv
Year: 2008
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: In this work, we derive the equations of motion governing the hydrodynamics of spin-F spinor condensates. We pursue a description based on standard physical variables (total density and superfluid velocity), alongside 2F `spin-nodes': unit vectors that describe the spin F state, and also exhibit the point-group symmetry of a spinor condensate's mean-field ground state. The hydrodynamic equations of motion consist of a mass continuity equation, 2F Landau-Lifshitz equations for the spin-nodes, and a modified Euler equation. In particular, we provide a generalization of the Mermin-Ho relation to spin one, and find an analytic solution for the skyrmion texture in the incompressible regime of a spin-half condensate. These results exhibit a beautiful geometrical structure that underlies the dynamics of spinor condensates.
description: 12 pages. First paper in two-part series
title: ÐÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ½Ð¾Ðµ Ð´Ð¸Ð·Ð°Ð¹Ð½-Ð³ÑÐ°ÑÐ¸ÑÐµÑÐºÐ¾Ðµ ÑÐ¾Ð¿ÑÐ¾Ð²Ð¾Ð¶Ð´ÐµÐ½Ð¸Ðµ ÐºÐ¾Ð»Ð»ÐµÐºÑÐ¸Ð¸ Ð¾Ð´ÐµÐ¶Ð´Ñ
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: ÐÐ¼Ð¸Ð½Ð¸Ð½Ð°, ÐÐ°ÑÐ¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: ÐºÐ¾Ð»Ð»ÐµÐºÑÐ¸Ñ Ð¾Ð´ÐµÐ¶Ð´Ñ
Ð³ÑÐ°ÑÐ¸ÑÐµÑÐºÐ¾Ðµ ÑÐ¾Ð¿ÑÐ¾Ð²Ð¾Ð¶Ð´ÐµÐ½Ð¸Ðµ
Ð³ÑÐ°ÑÐ¸ÑÐµÑÐºÐ¸Ð¹ Ð´Ð¸Ð·Ð°Ð¹Ð½
Ð²ÐµÐ±-ÑÐ°Ð¹Ñ
Ð¿Ð»Ð°ÐºÐ°Ñ
Ð±ÑÐºÐ»ÐµÑ

description: Ð¡Ð¾Ð·Ð´Ð°Ð½Ð¾ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ½Ð¾Ðµ Ð³ÑÐ°ÑÐ¸ÑÐµÑÐºÐ¾Ðµ ÑÐ¾Ð¿ÑÐ¾Ð²Ð¾Ð¶Ð´ÐµÐ½Ð¸Ðµ ÐºÐ¾Ð»Ð»ÐµÐºÑÐ¸Ð¸ Ð¾Ð´ÐµÐ¶Ð´Ñ ÐÐ¾ÑÐ¸Ð¾ ÐÑÐ±Ð¾. ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¾ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð°Ð½Ð°Ð»Ð¾Ð³Ð¾Ð². ÐÐ·ÑÑÐµÐ½Ñ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ñ Ð´Ð»Ñ ÑÐµÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ ÑÐ¾ÑÑÐ°Ð²Ð»ÑÑÑÐ¸Ñ Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ. Ð¡Ð¾Ð·Ð´Ð°Ð½Ñ Ð¿Ð»Ð°ÐºÐ°ÑÑ, Ð±ÑÐºÐ»ÐµÑ, Ð¿ÑÐ¸Ð³Ð»Ð°ÑÐµÐ½Ð¸Ñ, Ð¼Ð°ÐºÐµÑ ÑÐ°Ð¹ÑÐ°.
title: ÐÑÐµÐ½ÐºÐ° Ð¼Ð¾ÑÐ¸Ð²Ð°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ¾ÑÑÐ°Ð²Ð»ÑÑÑÐµÐ¹ Ð² ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ð¸ Ð¿ÐµÑÑÐ¾Ð½Ð°Ð»Ð¾Ð¼
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: ÐÐ°Ð»Ð¸Ð¼ÑÐ»Ð»Ð¸Ð½Ð°, ÐÐ°Ð»ÐµÑÐ¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: Ð¼Ð¾ÑÐ¸Ð²Ð°ÑÐ¸Ð¸ Ð¿ÐµÑÑÐ¾Ð½Ð°Ð»Ð°
ÑÐµÐ¾ÑÐ¸Ð¸ Ð¼Ð¾ÑÐ¸Ð²Ð°ÑÐ¸Ð¸
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MeerTRAP: Twelve Galactic fast transients detected in a real-time, commensal MeerKAT survey
Creators: name: Bezuidenhout, M. C.
name: Barr, E.
name: Caleb, M.
name: Driessen, L. N.
name: Jankowski, F.
name: Kramer, M.
name: Malenta, M.
name: Morello, V.
name: Rajwade, K.
name: Sanidas, S.
name: Stappers, B. W.
name: Surnis, M.
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: MeerTRAP is a real-time untargeted search project using the MeerKAT telescope to find single pulses from fast radio transients and pulsars. It is performed commensally with the MeerKAT large survey projects (LSPs), using data from up to 64 of MeerKAT's 13.96~m dishes to form hundreds of coherent beams on sky, each of which is processed in real time to search for millisecond-duration pulses. We present the first twelve Galactic sources discovered by MeerTRAP, with DMs in the range of 33--381~pc~cm$^{-3}$. One source may be Galactic or extragalactic depending on the Galactic electron density model assumed. Follow-up observations performed with the MeerKAT, Lovell, and Parkes radio telescopes have detected repeat pulses from seven of the twelve sources. Pulse periods have been determined for four sources. Another four sources could be localised to the arcsecond-level using a novel implementation of the tied-array beam localisation method.
description: 16 pages, 14 figures
Expression of TLR7 in the murine eye during the embryonic period and in the adult animal
Creators: name: Barajon, Isabella
name: Rasile, Marco
name: Arnaboldi, Francesca
name: Menon, Alessandra
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2013
Subjects: Toll-like receptors; TLR7; eye; development

description: In the present study, we evaluated Toll-like receptor 7 (TLR7) expression at different stages of the murine eye development and in the adult organ. In mammals, TLRs are best known for their immunitary function, however data from the literature are demonstrating that in analogy to their Drosophila homologue Toll, they also participate in developmental mechanisms (Okun, Griffioen and Mattson 2011, Shechter et al. 2008). Immunohistochemistry for TLR7 and double immunofluorescence for TLR7/PCNA were performed on E12, E14 and E16 formalin-fixed paraffin-embedded mouse heads and on eyes enucleated from 3 months adult mice Results of experiments indicate that TLR7 expression is present in different compartments of the mouse eye (cornea, pigmented epithelium, neural retina, and lens) during gestation both in proliferating and differentiating cells and that such expression persists also in the adult organ. These observations indicate that besides being involved in protective mechanisms in the adult eye, TLR7 is also likely involved in the morphogenetic processes of this complex organ to which cells and tissues of different embryological origin contribute.
description: Italian Journal of Anatomy and Embryology, Vol 117, No 2 (Supplement) 2012
Expression of Toll-like receptors 4 and 7 in the embryonic and adult pancreas, liver and adrenal gland of the mouse
Creators: name: Barajon, Isabella
name: Menon, Alessandra
name: Rasile, Marco
name: Arnaboldi, Francesca
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2013
Subjects: Toll-like receptors; adrenal gland; liver; pancreas; embryo

description: The role of Toll protein in development and immunity is very well understood in Drosophila melanogaster (Anderson et al.,1985). Conversely, the contribution of Tolllike receptors (TLRs) in mammalian development is just beginning to be revealed. In this study, we evaluated the expression of TLR4 and TLR7 by immunohistochemistry on paraffin-embedded tissue in the adrenal gland, liver and pancreas of mouse embryos from stages E12, E14 and E16 and in the adult organs. Results show that TLR4 and TLR7 start to be detectable during embryonic development already at the first stage examined (E12). This expression follows the maturation of the organs and is still present in the adult with a different distribution pattern. Before this study no data in the literature were present on TLR4 and 7 expression in mammalian splanchnic organs development and in the adult no localization studies were available for TLR7. A possible interpretation of the results suggests that, besides their immunitary function, TLRs might be involved in a shared mechanism that regulates proliferation and differentiation both in embryonic organs and adult organs (Sato et al., 2009). These results also suggest that the contribution of TLRs in the context of carcinogenesis should be investigated not only in relation to chronic inflammation and tissue damage but also in relation to their contribution to the process of organogenesis.
description: Italian Journal of Anatomy and Embryology, Vol 117, No 2 (Supplement) 2012
The parkinsonism-inducing neurotoxin MPTP produces severe changes in the cervical spinal cord
Creators: name: Bartalucci, Alessia
name: Ryskalin, Larisa
name: Parlanti, Paola
name: Demi, Cristina
name: Vivacqua, Giorgio
name: Paparelli, Antonio
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2013
Subjects: Parkinson’s disease; spinal cord; mice; stereological procedure

description: The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is commonly used in experimental parkinsonism due to its capacity to induce degeneration of nigrostriatal dopaminergic neurons and locus coeruleus noradrenaline-containing neurons. Recently it was demonstrated that administration of MPTP to mice induces spinal cord alterations consisting of changes in the alpha-synuclein immunostaining and loss of motor neurons. Interestingly, a relationship between motor neuron degeneration and motor symptoms has been reported also in Parkinson’s disease (PD) patients. On the other hand, several non-motor sensory alterations commonly reported in PD, such as increased spinal nociception and pain sensitivity, numbness, paresthesia/dysesthesia, suggest the involvement of spinal cord pathology in PD. In the present study we carried out an in-depth investigation of the spinal cord in a mouse model of PD, consisting of a chronic treatment with MPTP. At this purpose, C57Bl mice were treated with MPTP (5 mg/kg x 2 x die) for 21 days and the cervical spinal cord was dissected. Serial sections were collected in a strict anatomical order and analyzed at light microscopy following a stereological-like procedure. Smi-32 positive lamina IX motor neurons and gephyrin-positive lamina VII interneurons were counted throughout the whole cervical tract. Moreover, the immunopositivity for met-enkephalin, which is a marker of central fibers involved in pain transmission, was investigated. Our results demonstrate that MPTP decrease specific neuronal populations in the spinal cord. Noteworthy, motor neurons were significantly decreased by MPTP administration. These data, joined with finding obtained in human patients suggest that a dysfunction in the spinal cord might play a role in Parkinsonism.
description: Italian Journal of Anatomy and Embryology, Vol 117, No 2 (Supplement) 2012
α-Actinin behavior during C2C12 along differentiation
Creators: name: Burattini, Sabrina
name: Baldassarri, Valentina
name: Salucci, Sara
name: Ferri, Paola
name: Falcieri, Elisabetta
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2013
Subjects: α -Actinin; C2C12 cells; differentiation; Z-lines

description: α-Actinin is a cytoskeletal actin-binding protein (Ogura et al., 2009) that provides structural integrity of the sarcomeres and is located in the skeletal muscle Z-lines. It creates cross-links between actin filaments and, besides, it contributes to cytoskeleton organization and muscle contraction (Sjöblom et al., 2008). The aim of this work was to clear up the behavior of sarcomeric α-actinin in Z-lines formation during myogenic differentiation. For this purpose, C2C12 cells were analyzed at 0, 3, 7 days of differentiation, monitoring cell maturation and viability by means of inverted microscopy. Immuno-labeling of sarcomeric α-actinin was investigated both at CLSM and at TEM, using a mouse anti-α-actinin antibody followed by a FITC-conjugated goat antimouse or a 10nm colloidal gold conjugated anti-mouse antibody (Ferri et al., 2009), respectively. Immunofluorescence analysis reveals that, when differentiation is induced, initially α-actinin colocalizes with membrane-associated proteins, then it aligns longitudinally across the cytoplasm and, finally, it binds actin, giving rise to Z-lines. Immunogold study generally evidences a cytoplasmic and nuclear positivity, indicating a role for α-actinin in signaling, chromatin remodeling and in shuttle between these compartments (Dingovà et al., 2009; Lin et al., 2010). This study shows an α-actinin specific distribution and dynamic organization along the differentiation process.
description: Italian Journal of Anatomy and Embryology, Vol 117, No 2 (Supplement) 2012
Piezoelectic nanoparticles for mesenchymal stem cell stimulation
Creators: name: Danti, Serena
name: Rocca, Antonella
name: Moscato, Stefania
name: Barachini, Serena
name: Petrini, Mario
name: Ciofani, Gianni
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2013
Subjects: Nanoparticles; piezoelectric; mesenchymal stem cells; cytotoxicity

description: The challenge to guide and control stem cell fate has been addressed in multiple ways by researchers, making it self-evident that biomedical nanodevices can play a key role in regenerative medicine. This includes the development of nanomaterials which are chemically and/or physically active and the joint capability of controlling their response at the nanoscale. A step further in this pathway may be achieved using intracellular nanotransducers based on piezoelectric nanomaterials, since they can be activated by a wireless system (simply, ultrasound waves) placed outside the cell/tissue/ organ of interest. It is a matter of fact that nanoparticle-based strategies for nanomedical applications retain a salient potential for forefront advancements associated with important toxicological hurdles. The balance of such properties has thus become an intriguing challenge for a successful development of therapeutically effective nanosystems. Boron nitride nanotubes (BNNTs) are ceramic nanomaterials provided with excellent piezoelectric properties, enabling them to convert mechanic into electric energy, and viceversa [1]. The effectiveness of this stimulation method (i.e., US-activated BNNT-mediated stimulation) has been recently demonstrated by our group using neuronal-like cell lines [2]. Here we report our preliminary findings on the interactions of BNNTs with pluripotent cells, such as human mesenchymal stem cells (hMSCs) from the bone marrow (BM), hMSCs from trabecular bone (TB) and hMSCs from dental pulp (DP). Internalization and cytotoxicity were evaluated at different times. Our preliminary cytotoxicity assessment allowed the establishment of a non-toxic BNNT concentration to be used in vitro with MSC cultures. Moreover, investigation with transmission electron microscopy (TEM) confirmed that BNNTs were internalized at cytoplasm level, being mainly detected in membranal vesicles. Such results highlight the appealing property of biocompatible piezoelectric nanotransducers to trigger “electrically-sensitive” cell differentiation processes, thus disclosing future intriguing implications for new regenerative therapies.
description: Italian Journal of Anatomy and Embryology, Vol 117, No 2 (Supplement) 2012
On-chip manipulation of magnetic nanoparticles through domain walls conduits
Creators: name: Vavassori, P.
name: Gobbi, M.
name: Donolato, M.
name: Metlushko, V.
name: Ilic, B.
name: Cantoni, M.
name: Petti, D.
name: Brivio, S.
name: Bertacco, R.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The manipulation of geometrically constrained magnetic domain walls (DWs) in nanoscale magnetic strips has attracted much interest recently, with proposals for prospective memory and logic devices. Here we propose to use the high controllability of the motion of geometrically constrained DWs for the manipulation of individual nanoparticles on a chip with an active control of position at the nanometer scale. The proposed method exploits the fact that magnetic nanoparticles in solution can be captured by a DW, whose position can be manipulated with nanometric accuracy in a specifically designed magnetic nanowire structure. We show that the high control over DW nucleation, displacement, and annihilation processes in such structures can be used to capture, transport and release magnetic nanoparticles. As magnetic particles with functionalized surfaces are commonly used as molecule carriers or labels, the accurate control over the handling of the single magnetic nanoparticle is crucial for several applications including single molecule manipulation, separation, cells manipulation and biomagnetic sensing.
Acute treatment with relaxin attenuates the injury/ dysfunction induced by renal ischemia/reperfusion injury
Creators: name: Collino, Massimo
name: Rogazzo, Mara
name: Pini, Alessandro
name: Benetti, Elisa
name: Rosa, Arianna Carolina
name: Fantozzi, Roberto
name: Bani, Daniele
name: Masini, Emanuela
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2014
Subjects: relaxin; ischemia/reperfusion; kidney; inflammation; oxidative stress

description: Although preclinical and clinical studies have demonstrated that relaxin (RLX) ameliorates impaired renal function by exerting antifibrotic and regenerative effects, its role in renal ischemia/reperfusion (I/R) injury has never been investigated. Using a well-known rat model of 1h bilateral renal artery occlusion followed by 6 h reperfusion, we investigated the effects of human recombinant RLX (5 μg /Kg e.v.) given both at the beginning and after 3 h reperfusion. Serum and urinary indicators of renal injury and dysfunction were measured. Interestingly, administration of the exogenous RLX attenuated all markers of renal injury and dysfunction caused by I/R. Overall, we document here, for the first time, that RLX protects against I/R-induced renal injury and dysfunction. The results of this study offer good perspectives for the clinical potential of RLX in the medical treatment of renal diseases.
description: Italian Journal of Anatomy and Embryology, Vol 118, No 1 (Supplement) 2013
title: ÐÐ½Ð°Ð»Ð¸Ð· Ð²Ð½ÐµÑÐ½ÐµÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ Ð°ÑÐºÑÐ¸ÑÐµÑÐºÐ¸Ñ ÑÐµÐ³Ð¸Ð¾Ð½Ð¾Ð² ÐÐ°Ð½Ð°Ð´Ñ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
Creators: name: ÐÐ¸ÑÐ¸ÑÐ°, Ð¡Ð²ÐµÑÐ»Ð°Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2018
Subjects: ÐÑÐºÑÐ¸ÐºÐ°
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Using Agent to Coordinate Web Services
Creators: name: Liu, C. H.
name: Lin, Y. F.
name: Chen, Jason J. Y.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences

description: Traditionally, agent and web service are two separate research areas. We figure that, through agent communication, agent is suitable to coordinate web services. However, there exist agent communication problems due to the lack of uniform, cross-platform vocabulary. Fortunately, ontology defines a vocabulary. We thus propose a new agent communication layer and present the web ontology language (OWL)-based operational ontologies that provides a declarative description. It can be accessed by various engines to facilitate agent communication. Further, in our operational ontologies, we define the mental attitudes of agents that can be shared among other agents. Our architecture enhanced the 3APL agent platform, and it is implemented as an agent communication framework. Finally, we extended the framework to be compatible with the web ontology language for service (OWL-S), and then develop a movie recommendation system with four OWL-S semantic web services on the framework. The benefits of this work are: 1) dynamic web service coordination, 2) ontological reasoning through uniform representation, namely, the declarative description, and 3) easy reuse and extension of both ontology and engine through extending ontology.
description: 7 pages, International Journal of Computer Science and Information Security
Inferring the Helium abundance of extragalactic Globular Clusters using Integrated Spectra
Creators: name: Leath, Henry J.
name: Beasley, Michael A.
name: Vazdekis, Alexandre
name: Salvador-Rusiñol, Nuria
name: Gvozdenko, Anastasia
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The leading method for the determination of relevant stellar population parameters of unresolved extragalactic Globular Clusters is through the study of their integrated spectroscopy, where Balmer line-strength indices are considered to be age sensitive. Previously, a splitting in the highly optimised spectral line-strength index H$β_o$ was observed in a sample of Galactic globular clusters at all metallicities resulting in an apparent "upper branch" and "lower branch" of globular clusters in the H$β_o$ - [MgFe] diagram. This was suggested to be caused by the presence of hot Blue straggler stars (BSSs), resulting in an underestimation of 'spectroscopic' ages in the upper branch. Over a decade on, we look to re-evaluate these findings. We make use of new, large Galactic Globular Cluster integrated spectroscopy datasets. To produce a large, homogeneously combined sample we have considered a number of factors including the radial dependence of Balmer and metal lines. Using this new sample, in disagreement with previous work, we find the splitting in H$β_o$ only occurs at intermediate to high metallicities ([M/H]$>-1$), and is not the result of an increased fraction of BSSs, but rather is due to an increased Helium abundance. We explore the possible impact of varying Helium on simple stellar population models to provide a theoretical basis for our hypothesis and then use the relationship between upper branch candidacy and enhanced Helium to predict the Helium content of three M31 clusters. We discuss what this can tell us about their mass and fraction of first generation stars.
description: 15 pages, 13 figures, accepted for publication in MNRAS
D5.3 – WP 5 Scientific Report and Prototype Description – Y3
Creators: name: Amaryllis Raouzaiou
name: Sidiropoulos, Anestis
name: McCreadie, Richard
name: Poulakis, Yannis
name: Doulkeridis, Christos
name: Kousiouris, George
name: Jean-Didier Totow
name: Sgouros, Nikitas
name: Karagiorgou, Sophia
name: Petrou, Petros
name: Chatzimarkaki, Gina
name: Patiño, Marta
name: Alzúaz, Ainhoa Azqueta
Publisher: name: Zenodo
Year: 2021

description: BigDataStack delivers a complete high-performant stack of technologies addressing the needs of data operations and applications. The main objective of the dimensioning, modelling and interaction services building block of the overall BigDataStack environment is to provide all the interaction mechanisms, including the Process Modelling framework, the Data Toolkit, the Dimensioning Workbench, and the Visualization environment. These are required in order to exploit the added-value services of the “underlying” BigDataStack data-driven infrastructure management and the Data as a Service offerings.
Time-dependent transport via the generalized master equation through a finite quantum wire with an embedded subsystem
Creators: name: Gudmundsson, Vidar
name: Gainar, Cosmin
name: Tang, Chi-Shung
name: Moldoveanu, Valeriu
name: Manolescu, Andrei
Publisher: name: arXiv
Year: 2009
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The authors apply the generalized master equation to analyze time-dependent transport through a finite quantum wire with an embedded subsystem. The parabolic quantum wire and the leads with several subbands are described by a continuous model. We use an approach originally developed for a tight-binding description selecting the relevant states for transport around the bias-window defined around the values of the chemical potential in the left and right leads in order to capture the effects of the nontrivial geometry of the system in the transport. We observe a partial current reflection as a manifestation of a quasi-bound state in an embedded well and the formation of a resonance state between an off-set potential hill and the boundary of the system.
description: RevTeX (pdf-LaTeX), 12 pages with 19 included jpg figures
Xenograft of free or microencapsulated Sertoli cells as a potential therapy for experimental Type 2 Diabetes Mellitus
Creators: name: Luca, Giovanni
name: Calvitti, Mario
name: Mancuso, Francesca
name: Murdolo, Giuseppe
name: Arato, Iva
name: Falabella, Giulia
name: Tortoioli, Cristina
name: Lilli, Cinzia
name: Bellucci, Catia
name: Baroni, Tiziano
name: Bodo, Maria
name: Becchetti, Ennio
name: Calafiore, Riccardo
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2011

description: Introduction and Aim. Type 2 Diabetes Mellitus (T2DM), one of the world’s most important, common and costly diseases associated with devastating complications, is caused by insulin resistance mainly due to a chronic inflammation of the visceral adipose tissue with local and systemic increases in proinflammatory cytokines and adipokines such as tumor necrosis factor-α (TNF-α) and IL-6. Sertoli cells (SC), considered mere mechanical cell aids, have been recently revisited with respect to their functional competence showing that these cells may provide immunomodulatory and trophic factors that are able to ameliorate survival and development of different cell types and constitute an immuno-protective shield for transplantation in many diseases such as Type 1 Diabetes Mellitus. Aim of this work was to verify if the injection of free (subcutaneously) or microencapsulated (intraperitoneally) SC would reverse hyperglycaemia in db/db mice spontaneous T2DM Materials and Methods. Porcine pre-pubertal SC were isolated, according to previously established methods, after finely chopping the retrieval testicles, with double enzymatic digestion with Collagenase P and a mixed solution of trypsin and DNase I. SC enveloped in Barium alginate-based microcapsules (Ba-SCMCs) were prepared according to our method, by a mono air-jet device system. Free SC and Ba-SCMCs were examined as far as: (a) SC morphology by light microscopy; (b) SC viability, by fluorescence microscopy after staining with ethidium bromide and fluorescein diacetate; (c) SC in vitro function (α-aromatase activity and IGF-I secretion); (d) reversal of T2DM in spontaneous diabetes db/db mice, were concerned. Results. Ba-SCMCs showed excellent features in terms of size, morphology, sphericity and coalescence. SC viability, both in free and microencapsulated SC, was very high (over 90%). Very good α-aromatase activity and IGF-I secretion were associated with the examined SC preparations. Both subcutaneous free SC injection and intraperitoneal transplantation of Ba-SCMCs demonstrated a significant reduction, in 60% of the treated mice, of HbA1c (6.6 % vs 8.8 %) with a normalization of intraperitoneal glucose tolerance test. Conclusions. SC may be enveloped in Ba-SCMCs with no loss of their functional properties and morphology. Xenograft of SC, both free and enveloped in barium alginate microcapsules, induced an important reduction of HbA1c blood levels with a normalization of glucose tolerance test (IPGTT). This result might open new perspectives for the future therapy of human T2DM.
description: Italian Journal of Anatomy and Embryology, Vol 116, No 1 (Supplement) 2011