cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Enhancing quality-by-design through weighted goal programming: a case study on formulation of ultradeformable liposomes
Creators: name: Cabeza, Sonia Valverde
name: González-R, Pedro Luis
name: González-Rodríguez, María Luisa
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Optimization of pharmaceutical formulations requires advanced tools to ensure quality, safety, and efficacy. quality-by-design (QbD), introduced by the FDA, emphasizes understanding and controlling processes early in development. Advanced optimization methods, such as desirability, have surpassed traditional single-objective techniques. Others, such as weighted goal programming (WGP) offers unique advantages by integrating decision-maker preferences, enabling balanced solutions for complex drug delivery systems. This study applies WGP to optimize timolol (TM)-loaded nanoliposomes aligning with QbD principles. The optimization process followed six steps: identifying factors and responses, developing a Design of Experiments (DoE) plan, defining ideal and anti-ideal points, setting aspiration levels, assigning relative weights, and applying WGP compared to desirability function. Minimized and balanced deviations from aspiration levels served as criteria for selecting the most robust optimization results. Six responses were analyzed: vesicle size (z1), polydispersity index (z2), zeta potential (z3), deformability index (z4), phosphorus content (z5), and drug entrapment efficiency (z6). WGP produced a more balanced formulation that simultaneously optimized multiple responses. By incorporating the importance of each response, the WGP approach improved control over size, colloidal stability, and drug entrapment, based on its mathematical formulation. Comparative analysis with the desirability function confirmed that WGP effectively addressed potential tradeoffs without oversimplifying conflicting objectives. This case-study demonstrates WGP potential as an advanced multi-objective optimization tool for pharmaceutical applications, improving upon traditional methods in complex formulations. Its ability to harmonize multiple critical attributes in line with QbD highlights its value in developing high-quality pharmaceutical products.
The what and where of adding channel noise to the Hodgkin-Huxley equations
Creators: name: Goldwyn, Joshua H.
name: Shea-Brown, Eric
Publisher: name: arXiv
Year: 2011
Subjects: subject: Neurons and Cognition (q-bio.NC)
subject: Dynamical Systems (math.DS)
subject: FOS: Biological sciences
subject: FOS: Mathematics

description: One of the most celebrated successes in computational biology is the Hodgkin-Huxley framework for modeling electrically active cells. This framework, expressed through a set of differential equations, synthesizes the impact of ionic currents on a cell's voltage -- and the highly nonlinear impact of that voltage back on the currents themselves -- into the rapid push and pull of the action potential. Latter studies confirmed that these cellular dynamics are orchestrated by individual ion channels, whose conformational changes regulate the conductance of each ionic current. Thus, kinetic equations familiar from physical chemistry are the natural setting for describing conductances; for small-to-moderate numbers of channels, these will predict fluctuations in conductances and stochasticity in the resulting action potentials. At first glance, the kinetic equations provide a far more complex (and higher-dimensional) description than the original Hodgkin-Huxley equations. This has prompted more than a decade of efforts to capture channel fluctuations with noise terms added to the Hodgkin-Huxley equations. Many of these approaches, while intuitively appealing, produce quantitative errors when compared to kinetic equations; others, as only very recently demonstrated, are both accurate and relatively simple. We review what works, what doesn't, and why, seeking to build a bridge to well-established results for the deterministic Hodgkin-Huxley equations. As such, we hope that this review will speed emerging studies of how channel noise modulates electrophysiological dynamics and function. We supply user-friendly Matlab simulation code of these stochastic versions of the Hodgkin-Huxley equations on the ModelDB website (accession number 138950) and http://www.amath.washington.edu/~etsb/tutorials.html.
description: 14 pages, 3 figures, review article
A novel synthetic approach for the Piperazynyl Pyrimidine Intermediate: Focus on the cost cutting of Buspirone drug at commercial level
Creators: name: Nayak, Anjan Kumar
name: Tripathy, Divya Bajpai
name: Pendharkar, Dhananjay
name: Sharma, Vijay Kumar
name: Sharma, Gaurav
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Ecology
subject: FOS: Biological sciences
subject: Plant Biology

description: Buspirone is a critical in treatment for generalized anxiety disorder (GAD), but the synthesis of its key intermediate, 2-(piperazin-1-yl)pyrimidine faces challenges in terms of cost, yield and purity. Traditional synthesis methods are hindered by high material costs and significant by-product formation, necessitating a more efficient and economical approach. To develop a novel, cost-effective synthesis strategy for the 2-(piperazin-1-yl)pyrimidine intermediate that improves yield and purity while reducing production costs and environmental impact. A four-step synthesis process was optimized as follows: First, piperazine reacts with sulfuric acid and cyanamide, followed by precipitation with cold methanol. Next, 1,1,3,3-Tetramethoxypropane reacts with hydrochloric acid and amidine and the mixture was extracted with dichloromethane (DCM). In the third step, the product was dissolved in isopropanol (IPA), treated with charcoal and converted to the oxalate salt using oxalic acid. Finally, the oxalate salt was converted to the freebase with ammonia, followed by a final extraction with DCM. Key variables such as reagent equivalents, reaction conditions and purification techniques were systematically optimized throughout the process. The optimized process achieved a purity level of over 99% and reduced production costs by 25-30%. Significant improvements included controlled bis-product formation with cyanamide, effective addition of 1,1,3,3-Tetramethoxypropane and efficient removal of by-products through oxalate salt formation and charcoal treatment. The developed synthesis method for 2-(piperazin-1-yl)pyrimidine was both cost-effective and efficient, significantly enhancing the yield and purity. This method is highly suitable for large-scale pharmaceutical production, aligning with industry goals of improved process efficiency, cost reduction and environmental sustainability.
Nonlinear Dual-Mode Control of Variable-Speed Wind Turbines with Doubly Fed Induction Generators
Creators: name: Tang, Choon Yik
name: Guo, Yi
name: Jiang, John N.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics

description: This paper presents a feedback/feedforward nonlinear controller for variable-speed wind turbines with doubly fed induction generators. By appropriately adjusting the rotor voltages and the blade pitch angle, the controller simultaneously enables: (a) control of the active power in both the maximum power tracking and power regulation modes, (b) seamless switching between the two modes, and (c) control of the reactive power so that a desirable power factor is maintained. Unlike many existing designs, the controller is developed based on original, nonlinear, electromechanically-coupled models of wind turbines, without attempting approximate linearization. Its development consists of three steps: (i) employ feedback linearization to exactly cancel some of the nonlinearities and perform arbitrary pole placement, (ii) design a speed controller that makes the rotor angular velocity track a desired reference whenever possible, and (iii) introduce a Lyapunov-like function and present a gradient-based approach for minimizing this function. The effectiveness of the controller is demonstrated through simulation of a wind turbine operating under several scenarios.
description: 14 pages, 9 figures, accepted for publication in IEEE Transactions on Control Systems Technology
Global terrestrial water storage and drought severity under climate change
Creators: name: Yadu Pokhrel
Publisher: name: figshare
Year: 2021
Subjects: subject: 40104 Climate Change Processes
subject: FOS: Earth and related environmental sciences
subject: Climate Science
subject: Hydrology
subject: 40608 Surfacewater Hydrology

description: Processed data needed to reproduce the figures in the main text of the paper (Pokhrel et al., 2021, Nature Climate Change).
Global terrestrial water storage and drought severity under climate change
Creators: name: Yadu Pokhrel
Publisher: name: figshare
Year: 2020
Subjects: subject: 40104 Climate Change Processes
subject: FOS: Earth and related environmental sciences
subject: Climate Science
subject: Hydrology
subject: 40608 Surfacewater Hydrology

description: Processed data needed to reproduce the figures in the main text of the paper (Pokhrel et al., 2021, Nature Climate Change).
Phonological Targets and Northern Cape York Sandhi
Creators: name: Crowley, Terry (Ed.)
Publisher: name: Pacific Linguistics
Year: 1980

description: PHONOLOGICAL TARGETS AND NORTHERN CAPE YORK SANDHI. 241 0. Introduction 241 1. Background 241 2. Sandhi in the Northern Cape York Sub-group 243 2.1. Atampaya Sandhi 243 2.2. Explanation of the Correspondences 247 2.3. Yadhaykenu Sandhi 249 2.4. Angkamuthi Sandhi 251 3. Proto-Northern Paman and its Daughter Languages 252 4. Frills on the Anti-VV Constraint 255Notes 257Bibliography 258
Design concept for an IoT-based earthquake early warning platform
Creators: name: Taale, Alireza
Publisher: name: University of British Columbia
Year: 2021

description: This dissertation aims to present a full-stack concept design for an earthquake early warning platform utilizing a dense array of sensors embedded in consumer electronic devices. The proposed design includes four systems: observation, estimation, prediction, and decision systems, each with a specific type of intelligence. A novel change detection technique, specially devised for the observation system, is responsible for detecting and estimating the arrival time. Knowing the geographical location and arrival times collected from various sensors allows the platform to compute an approximate location of the event through an optimization method. The performance results on 732 ground motions indicate that the error in arrival time estimation is less than 1.5 𝑠, on average. Meanwhile, the event location estimation average error is less than 16 𝑘𝑚, with a 99% confidence level. Furthermore, a novel earthquake intensity prediction model based on a neural network structure is responsible for evaluating the size of the event. The proposed prediction model yields 57% standard error over 4691 carefully selected ground motions. In contrast, the performance results of the voting process responsible for updating the alarm status indicate the overall accuracy of 75% for the platform; that is, three-quarters of the ground motions are correctly classified, on average. However, the average false alarm rates are 20% to 30%. Accordingly, investigating the effect of the threshold value on the false alarm rates illustrates that consideration of the practicality in the design concept allows the selection of an optimal alarm threshold. Utilizing the Internet of Things (IoT) infrastructure for earthquake early warning is a compelling and challenging alternative compared to conventional platforms. Future works require collaboration between academia and industry to devise guidelines for reconfiguring IoT infrastructure and improving the performance of individual earthquake early warning systems.
title: Evaluating selective culling with vaccination to control wildlife disease: badgers and bovine tuberculosis (bTB)
Creators: name: Smith, G. C.
name: Wilkinson, D.
Publisher: name: Julius Kühn-Institut
Year: 2011
Subjects: subject: cattle
subject: combined control strategies
subject: Mycobacterium bovis
subject: perturbation
subject: spatial model

description: Julius-Kühn-Archiv; 432; 201-202
On the initial-value problem of the Maxwell-Lorentz equations
Creators: name: Perlick, Volker
name: Carr, Anthony
Publisher: name: arXiv
Year: 2010
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We consider the Maxwell-Lorentz equations, i.e., the equation of motion of a charged dust coupled to Maxwell's equations, on an arbitrary general-relativistic spacetime. We decompose this system of equations into evolution equations and constraints, and we demonstrate that the evolution equations are strongly hyperbolic. This result guarantees that the initial-value problem of the Maxwell-Lorentz equations is well-posed. We illustrate this general result with a discussion of spherically symmetric solutions on Minkowski spacetime.
description: 13 pages, 3 figures. One reference added. To appear in J. Phys. A
ENHANCING QUALITY-BY-DESIGN THROUGH WEIGHTED GOAL PROGRAMMING: A CASE STUDY ON FORMULATION OF ULTRADEFORMABLE LIPOSOMES
Creators: name: Cabeza, Sonia Valverde
name: González-R, Pedro Luis
name: González-Rodríguez, María Luisa
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Optimization of pharmaceutical formulations requires advanced tools to ensure quality, safety, and efficacy. Quality-by-Design (QbD), introduced by the FDA, emphasizes understanding and controlling processes early in development. Advanced optimization methods, such as desirability, have surpassed traditional single-objective techniques. Others such as Weighted Goal Programming (WGP) offers unique advantages by integrating decision-maker preferences, enabling balanced solutions for complex drug delivery systems. This study applies WGP to optimize timolol-loaded nanoliposomes aligning with QbD principles. The optimization process followed six steps: identifying factors and responses, developing a Design of Experiments (DoE) plan, defining ideal and anti-ideal points, setting aspiration levels, assigning relative weights, and applying WGP compared to desirability function. Minimized and balanced deviations from aspiration levels served as criteria for selecting the most robust optimization results. Six responses were analyzed: vesicle size (z1), polydispersity index (z2), zeta potential (z3), deformability index (z4), phosphorus content (z5), and drug entrapment efficiency (z6). WGP produced a more balanced formulation that simultaneously optimized multiple responses. By incorporating the importance of each response, the WGP approach improved control over size, colloidal stability, and drug entrapment, based on its mathematical formulation. Comparative analysis with the desirability function confirmed that WGP effectively addressed potential trade-offs without oversimplifying conflicting objectives. This case-study demonstrates WGP potential as an advanced multi-objective optimization tool for pharmaceutical applications, improving upon traditional methods in complex formulations. Its ability to harmonize multiple critical attributes in line with QbD highlights its value in developing high-quality pharmaceutical products.
Climate Change, Terrestrial Water Storage, and Drought
Creators: name: Yadu Pokhrel
Publisher: name: figshare
Year: 2020
Subjects: subject: 40104 Climate Change Processes
subject: FOS: Earth and related environmental sciences
subject: Climate Science
subject: Hydrology
subject: 40608 Surfacewater Hydrology

description: Processed data needed to reproduce the figures in the main text of the paper (Pokhrel et al., 2021).
title: Ð¡Ð¾Ð²ÐµÑÑÐµÐ½ÑÑÐ²Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸Ð¸ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²Ð° Ð±Ð¸ÑÐºÐ²Ð¸ÑÐ½Ð¾Ð³Ð¾ Ð¿Ð¾Ð»ÑÑÐ°Ð±ÑÐ¸ÐºÐ°ÑÐ° Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð·ÐµÐ»ÐµÐ½Ð¾Ð³Ð¾ ÑÐ°Ñ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Improving the production technology of biscuit cake with the use of green tea
Creators: name: ÐÐ½Ð°Ð½ÑÑÐº, ÐÐ°ÑÐ¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2019
Subjects: Ð±Ð¸ÑÐºÐ²Ð¸ÑÐ½ÑÐ¹ Ð¿Ð¾Ð»ÑÑÐ°Ð±ÑÐ¸ÐºÐ°Ñ
Ð·ÐµÐ»ÐµÐ½ÑÐ¹ ÑÐ°Ð¹
Ð¼ÑÑÐ½ÑÐµ ÐºÐ¾Ð½Ð´Ð¸ÑÐµÑÑÐºÐ¸Ðµ Ð¸Ð·Ð´ÐµÐ»Ð¸Ñ
ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¿Ð¾ÐºÐ°Ð·Ð°ÑÐµÐ»Ð¸
ÑÐµÐ½ÑÐ°
biscuit cake mix
green tea
flour confectionery
tech-nological indicators
sencha

description: ÐÑÐ¾Ð¸Ð·Ð²ÐµÐ´ÐµÐ½ Ð°Ð½Ð°Ð»Ð¸Ð· ÑÑÐ½ÐºÐ° Ð¼ÑÑÐ½ÑÑ ÐºÐ¾Ð½Ð´Ð¸ÑÐµÑÑÐºÐ¸Ñ Ð¸Ð·Ð´ÐµÐ»Ð¸Ð¹ Ð¸ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸Ðº Ð·ÐµÐ»ÐµÐ½Ð¾Ð³Ð¾ ÑÐ°Ñ, Ð²ÑÐ»ÐµÐ´ÑÑÐ²Ð¸Ðµ ÑÐµÐ³Ð¾ Ð±ÑÐ»Ð° Ð¾Ð±Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð° Ð°ÐºÑÑÐ°Ð»ÑÐ½Ð¾ÑÑÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ñ Ð·ÐµÐ»ÐµÐ½Ð¾Ð³Ð¾ ÑÐ°Ñ Ð² Ð±Ð¸ÑÐºÐ²Ð¸ÑÐ½Ð¾Ð¼ Ð¿Ð¾Ð»ÑÑÐ°Ð±ÑÐ¸ÐºÐ°ÑÐµ. ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ñ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¿Ð¾ÐºÐ°Ð·Ð°ÑÐµÐ»Ð¸ Ð¿ÑÐµÐ½Ð¸ÑÐ½Ð¾Ð¹ Ð¼ÑÐºÐ¸, Ð·ÐµÐ»ÐµÐ½Ð¾Ð³Ð¾ ÑÐ°Ñ, Ð¸Ñ ÑÐ¼ÐµÑÐµÐ¹ Ð¸ Ð±Ð¸ÑÐºÐ²Ð¸ÑÐ½ÑÑ Ð¿Ð¾Ð»ÑÑÐ°Ð±ÑÐ¸ÐºÐ°ÑÐ¾Ð² Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð·ÐµÐ»ÐµÐ½Ð¾Ð³Ð¾ ÑÐ°Ñ. Ð¢Ð°ÐºÐ¶Ðµ Ð±ÑÐ» ÑÐ¿ÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½ ÐºÐ¾Ð½Ð´Ð¸ÑÐµÑÑÐºÐ¸Ð¹ ÑÐµÑ Ð¿Ð¾ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²Ñ Ð±Ð¸ÑÐºÐ²Ð¸ÑÐ½ÑÑ Ð¸Ð·Ð´ÐµÐ»Ð¸Ð¹ Ð¸ Ð¿ÑÐ¾ÑÐ¸ÑÑÐ¾Ð»ÐµÐ¹. Ð Ð°ÑÑÑÐ¸ÑÐ°Ð½Ñ Ð¿Ð»Ð¾ÑÐ°Ð´Ð¸ Ð¿Ð¾Ð¼ÐµÑÐµÐ½Ð¸Ð¹ Ð¸ Ð¾Ð±Ð¾ÑÑÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð½Ð° Ð´Ð°Ð½Ð½Ð¾Ð¼ Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ð¸. Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ñ ÑÑÐµÐ¼Ñ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²Ð° Ð´Ð»Ñ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¸ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¿ÑÐ¾ÑÐµÑÑÐ°, Ð¾Ð±ÐµÑÐ¿ÐµÑÐ¸Ð²Ð°ÑÑÐ¸Ðµ Ð±ÐµÐ·Ð¾Ð¿Ð°ÑÐ½ÑÐµ Ð¸ ÐºÐ¾Ð¼ÑÐ¾ÑÑÐ½ÑÐµ ÑÑÐ»Ð¾Ð²Ð¸Ñ ÑÑÑÐ´Ð°.
description: The analysis of the market of flour confectionery products and characteristics of green tea was made, as a result of which the relevance of using green tea in biscuit semi-finished product was justified. The technological parameters of wheat flour, green tea, their mixtures and biscuit semi-finished products using green tea were studied. A confectionery shop for the production of biscuit products and profiteroles was also designed. Calculated space and equipment in the enterprise. Developed production schemes for the organization of the technological process, ensuring safe and comfortable working conditions.
Ten Months of Digital Reading
Creators: name: Petras, Vivien
name: Braslavski, Pavel
name: Likhosherstov, Valery
name: Gäde, Maria
Publisher: name: Humboldt-Universität zu Berlin
Year: 2016
Subjects: subject: digital reading
subject: reading behavior
subject: user modeling
subject: log analysis
subject: 020 Bibliotheks- und Informationswissenschaften

description: We address digital reading practices in Russia analyzing 10 months of logging data from a commercial ebook mobile app.We describe the data and focus on three aspects: reading schedule, reading speed, and book abandonment. The exploratory study proves a high potential of the data and proposed approach.
title: Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° ÐºÐ»Ð¸ÐµÐ½Ñ-ÑÐµÑÐ²ÐµÑÐ½Ð¾Ð³Ð¾ Ð¿ÑÐ¸Ð»Ð¾Ð¶ÐµÐ½Ð¸Ñ Ð´Ð»Ñ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ñ ÐºÐ°Ð»Ð¾ÑÐ¸Ð¹Ð½Ð¾ÑÑÐ¸ ÑÐ¿Ð¾ÑÑÐµÐ±Ð»ÑÐµÐ¼ÑÑ Ð¿ÑÐ¾Ð´ÑÐºÑÐ¾Ð²
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Development of a mobile application to determine the caloric content of the product from a photo
Creators: name: ÐÐ¸ÑÐ¾Ð½Ð¾Ð², ÐÑÑÐµÐ¼
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2019
Subjects: Ð½ÐµÐ¹ÑÐ¾Ð½Ð½ÑÐµ ÑÐµÑÐ¸
ÐºÐ»Ð°ÑÑÐµÑÐ¸Ð·Ð°ÑÐ¸Ñ
Ð¼Ð°ÑÐ¸Ð½Ð½Ð¾Ðµ Ð¾Ð±ÑÑÐµÐ½Ð¸Ðµ
Ð¾Ð±ÑÑÐµÐ½Ð¸Ðµ Ñ ÑÑÐ¸ÑÐµÐ»ÐµÐ¼
Ð¾Ð±ÑÑÐµÐ½Ð¸Ðµ Ð±ÐµÐ· ÑÑÐ¸ÑÐµÐ»Ñ
Ð¾Ð±ÑÑÐ°ÑÑÐ¸Ð¹ ÐºÐ¾ÑÑÑÐ¸ÑÐ¸ÐµÐ½Ñ
Ð½ÐµÐ¹ÑÐ¾Ð½
ÑÐµÐºÑÑÑÐµÐ½ÑÐ½ÑÐµ ÑÐµÑÐ¸
neural networks
clustering
machine learning
teacher training
unsupervised learning
learning coefficient
neuron
recurrent networks

description: Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ Ð²ÑÐ¿ÑÑÐºÐ½Ð¾Ð¹ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð¸Ð·ÑÑÐµÐ½Ñ Ð½ÐµÐ¹ÑÐ¾Ð½Ð½ÑÐµ ÑÐµÑÐ¸ Ð¸ Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð¾ Ð¿ÑÐ¸Ð»Ð¾Ð¶ÐµÐ½Ð¸Ðµ, ÑÐ¿Ð¾ÑÐ¾Ð±Ð½Ð¾Ðµ Ð¿Ð¾ ÑÐ¾ÑÐ¾Ð³ÑÐ°ÑÐ¸Ð¸ Ð¿ÑÐ¾Ð´ÑÐºÑÐ° Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÑÑÑ ÐµÐ³Ð¾ ÐºÐ°Ð»Ð¾ÑÐ¸Ð¹Ð½Ð¾ÑÑÑ. Ð¡ÑÑÑÐºÑÑÑÐ° ÑÐ°Ð±Ð¾ÑÑ Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ð° ÑÐµÑÑÑÑÐ¼Ñ Ð³Ð»Ð°Ð²Ð°Ð¼Ð¸, Ð·Ð°ÐºÐ»ÑÑÐµÐ½Ð¸ÐµÐ¼ Ð¸ ÑÐ¿Ð¸ÑÐºÐ¾Ð¼ Ð»Ð¸ÑÐµÑÐ°ÑÑÑÑ. Ð Ð¿ÐµÑÐ²Ð¾Ð¹ Ð³Ð»Ð°Ð²Ðµ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ñ Ð°ÐºÑÑÐ°Ð»ÑÐ½Ð¾ÑÑÑ ÑÐµÐ¼Ñ, ÑÐµÐ»Ð¸ Ð¸ Ð·Ð°Ð´Ð°ÑÐ¸, Ð¿Ð¾ÑÑÐ°Ð²Ð»ÐµÐ½Ð½ÑÐµ Ð² ÑÐ°Ð±Ð¾ÑÐµ, Ð¾Ð±ÑÐµÐºÑ Ð¸ Ð¿ÑÐµÐ´Ð¼ÐµÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ. Ð Ð·Ð°ÐºÐ»ÑÑÐµÐ½Ð¸Ð¸, ÑÐ´ÐµÐ»Ð°Ð½Ñ Ð²ÑÐ²Ð¾Ð´Ñ Ð¾ Ð¿ÑÐ¾Ð´ÐµÐ»Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð¸ Ð¿Ð¾Ð´Ð²ÐµÐ´ÐµÐ½ Ð¸ÑÐ¾Ð³ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ.
description: In this final qualifying work, neural networks are studied and an application has been developed that is capable of determining its caloric content from a photo of a product.
The structure of the work is represented by four chapters, conclusion and list of references.
The first chapter identifies the relevance of the topic, goals and objectives set in the work, the object and subject of research. In conclusion, conclusions were drawn on the work done and the research was summarized.
Implications of the Fermi-LAT diffuse gamma-ray measurements on annihilating or decaying Dark Matter
Creators: name: Hütsi, Gert
name: Hektor, Andi
name: Raidal, Martti
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We analyze the recently published Fermi-LAT diffuse gamma-ray measurements in the context of leptonically annihilating or decaying dark matter (DM) with the aim to explain simultaneously the isotropic diffuse gamma-ray and the PAMELA, Fermi and HESS (PFH) anomalous $e^\pm$ data. Five different DM annihilation/decay channels $2e$, $2μ$, $2τ$, $4e$, or $4μ$ (the latter two via an intermediate light particle $ϕ$) are generated with PYTHIA. We calculate both the Galactic and extragalactic prompt and inverse Compton (IC) contributions to the resulting gamma-ray spectra. To find the Galactic IC spectra we use the interstellar radiation field model from the latest release of GALPROP. For the extragalactic signal we show that the amplitude of the prompt gamma-emission is very sensitive to the assumed model for the extragalactic background light. For our Galaxy we use the Einasto, NFW and Isothermal DM density profiles and include the effects of DM substructure assuming a simple subhalo model. Our calculations show that for the annihilating DM the extragalactic gamma-ray signal can dominate only if rather extreme power-law concentration-mass relation $C(M)$ is used, while more realistic $C(M)$ relations make the extragalactic component comparable or subdominant to the Galactic signal. For the decaying DM the Galactic signal always exceeds the extragalactic one. In the case of annihilating DM the PFH favored parameters can be ruled out only if power-law $C(M)$ relation is assumed. For DM decaying into $2μ$ or $4μ$ the PFH favored DM parameters are not in conflict with the Fermi gamma-ray data. We find that, due to the (almost) featureless Galactic IC spectrum and the DM halo substructure, annihilating DM may give a good simultaneous fit to the isotropic diffuse gamma-ray and to the PFH $e^\pm$ data without being in clear conflict with the other Fermi-LAT gamma-ray measurements.
description: Accepted for publication in JCAP, added missing references, new Figs. 9 \& 10, 35 pages
The behavior of a many particle cathode in a lithium-ion battery
Creators: name: Dreyer, Wolfgang
name: Guhlke, Clemens
name: Huth, Robert
Publisher: name: Weierstrass Institute
Year: 2009
Subjects: subject: lithium-ion batteries
subject: thermodynamics
subject: phase transistion
subject: hysteresis
subject: many particle system
subject: chemical potential
subject: elasticity
subject: 74N30
subject: 74A15
subject: 74F20
subject: 74G65
subject: 82.47.Aa
subject: 82.60.Hc
subject: 82.60.Qr
subject: 83.10.Tv

description: We study the almost reversible storage process of charging and discharging of lithium-ion batteries. That process is accompanied by a phase transition and charging and discharging run along different paths, so that hysteretic behavior is observed. We are interested in the storage problem of the cathode of a lithium-ion battery consisting of a system of many iron phosphate (FePO4) particles. There are mathematical models, see [DGJ08], [DGGHJ09] and [DG09], that describe phase transitions and hysteresis exclusively in a single storage particle and they can describe the observed hysteretic voltage-charge plots with almost horizontal plateaus. Interestingly the models predict that the coexistence of a 2-phase system in an individual particle disappears, if its size is below a critical value. The disappearance of the phase transition in the single particle model implies the disappearance of the hysteresis. However, in the experiment hysteretic behavior survives. In other words: The behavior of a storage system consisting of many particles is qualitatively independent of the fact whether the individual particles itself develop a 2-phase system or if they remain in a single phase state. This apparent paradoxical observation will be resolved in this article by a many particle model. It will be shown that if each of the individual particles is in a homogeneous state, nevertheless the many particle ensemble exhibits phase transition and hysteresis, because one of the two phases is realized in some part of the particles while the remaining particles are in the other phase. Mathematically speaking this phenomenon is due to the non-monotonicity of the relation between the chemical potential and the lithium mole fraction. The pressure-radius relation of a spherical elastic rubber balloon also exhibits non-monotone behavior. In fact, a system of many interconnected balloons behaves correspondingly to a cathode consisting of many storage particles. This analogy between the two systems is important, because the predictions of the many particle model can easier be tested with rubber balloons of macroscopic size than with an ensemble of microscopically small (FePO4) particles.
Norman Pama Historical Phonology
Creators: name: Black, Paul (Ed.)
Publisher: name: Pacific Linguistics
Year: 1980

description: NORMAN PAMA HISTORICAL PHONOLOGY. 181Map 182 1. 'Proto-Paman' and Pre-Norman Pama 183 2. The Languages 187 3. Norman Pama as a Genetic Group 191 4. Phonologies of the Attested Languages 194 5. Pre-Norman Pama Phonology 198 6. Consonant Reflexes in Norman Pama 204 7. Consonant Loss and Lenition 206 8. Vowel Developments in Norman Pama 209 9. Walangama Phonological Developments 216Notes 219Appendix - Reconstructed Forms 220Bibliography 236
title: ÐÐ½ÐµÐ´ÑÐµÐ½Ð¸Ðµ ÑÐ¸ÑÑÐµÐ¼Ñ ÑÐ°Ð±Ð¾ÑÑ Ñ Ð·Ð°ÑÐ²ÐºÐ°Ð¼Ð¸ Ð¸ Ð¸Ð½ÑÐ¸Ð´ÐµÐ½ÑÐ°Ð¼Ð¸ GLPI Ð² ÐÐÐÐ£ Ð¡ÐÐ¨ â 655
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: implementation of the system of work with applications and incidents of glpi in GBOU SOSH â 655
Creators: name: ÐÐ¾ÑÑÑÐ¸ÐºÐ¾Ð², ÐÐ²Ð°Ð½
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2019
Subjects: Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½ÑÐµ ÑÐ¸ÑÑÐµÐ¼Ñ
Ð¸Ð½ÑÐ¸Ð´ÐµÐ½ÑÑ
Ð·Ð°ÑÐ²ÐºÐ¸
help desk
Ð°Ð²ÑÐ¾Ð¼Ð°ÑÐ¸Ð·Ð°ÑÐ¸Ñ
Ð²Ð½ÐµÐ´ÑÐµÐ½Ð¸Ðµ
information systems
incidents
applications
automation
implementation

description: ÐÐ±ÑÐµÐºÑÐ¾Ð¼ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐ²Ð»ÑÐµÑÑÑ ÑÐºÐ¾Ð»Ð° â 655.
 Ð¦ÐµÐ»ÑÑ Ð²ÑÐ¿ÑÑÐºÐ½Ð¾Ð¹ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ ÑÐ²Ð»ÑÐµÑÑÑ Ð²Ð½ÐµÐ´ÑÐµÐ½Ð¸Ðµ GLPI - ÑÐ¸ÑÑÐµÐ¼Ñ ÑÐ°Ð±Ð¾ÑÑ Ñ Ð·Ð°ÑÐ²ÐºÐ°Ð¼Ð¸ Ð¸ Ð¸Ð½ÑÐ¸Ð´ÐµÐ½ÑÐ°Ð¼Ð¸ Ð² ÑÐºÐ¾Ð»Ðµ â 655.
 Ð Ð¿ÑÐ¾ÑÐµÑÑÐµ Ð²Ð½ÐµÐ´ÑÐµÐ½Ð¸Ñ Ð±ÑÐ´ÐµÑ Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸ÑÑÑÑ ÐºÑÐ°ÑÐºÐ¸Ð¹ Ð¾Ð±Ð·Ð¾Ñ ÑÑÑÑÐºÑÑÑÑ ÑÐºÐ¾Ð»Ñ â 655, Ð° ÑÐ°ÐºÐ¶Ðµ Ð¾Ð±Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð° Ð½ÐµÐ¾Ð±ÑÐ¾Ð´Ð¸Ð¼Ð¾ÑÑÑ Ð²Ð½ÐµÐ´ÑÐµÐ½Ð¸Ñ ÑÐ¸ÑÑÐµÐ¼Ñ Ð² Ð´Ð°Ð½Ð½ÑÑ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ñ. Ð ÑÐ°Ð¼ÐºÐ°Ñ Ð¸Ð½ÑÐµÐ³ÑÐ°ÑÐ¸Ð¸ Ð±ÑÐ´ÐµÑ Ð¾Ð¿Ð¸ÑÐ°Ð½ ÑÑÐ½ÐºÑÐ¸Ð¾Ð½Ð°Ð» ÑÐ¸ÑÑÐµÐ¼Ñ Ð¸ Ð¿Ð¾Ð´ÑÐ¾Ð±Ð½ÑÐ¹ Ð¿Ð»Ð°Ð½ ÐµÐ³Ð¾ Ð²Ð½ÐµÐ´ÑÐµÐ½Ð¸Ñ. 
 Ð ÐµÐ·ÑÐ»ÑÑÐ°ÑÐ¾Ð¼ Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ ÑÑÐ°Ð½ÐµÑ Ð²Ð½ÐµÐ´ÑÐµÐ½Ð¸Ñ ÑÐ¸ÑÑÐµÐ¼Ñ Â«GLPIÂ» Ð² ÐÐÐÐ£ Ð¡ÐÐ¨ â 655(ÐÐ¾ÑÑÐ´Ð°ÑÑÑÐ²ÐµÐ½Ð½Ð¾Ðµ Ð±ÑÐ´Ð¶ÐµÑÐ½Ð¾Ðµ Ð¾Ð±ÑÐµÐ¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°ÑÐµÐ»ÑÐ½Ð¾Ðµ ÑÑÑÐµÐ¶Ð´ÐµÐ½Ð¸Ðµ ÑÑÐµÐ´Ð½ÑÑ Ð¾Ð±ÑÐµÐ¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°ÑÐµÐ»ÑÐ½Ð°Ñ ÑÐºÐ¾Ð»Ð° â 655) Ñ Ð¿Ð¾ÑÐ»Ðµ-Ð´ÑÑÑÐ¸Ð¼ Ð¾Ð±ÑÐ»ÑÐ¶Ð¸Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð²Ð½ÐµÐ´ÑÐµÐ½Ð½Ð¾Ð³Ð¾ ÑÐµÑÐµÐ½Ð¸Ñ.
description: The object of study is school number 655.
 The goal of the final qualification work is the implementation of GLPI - the system of work with applications and incidents at school No. 655.
In the process of implementation, a brief review of the structure of school No. 655 will be carried out, and the need for introducing the system into this organization will be substantiated. As part of the integration, the functionality of the system and a detailed plan for its implementation will be described.
The result of this work will be the introduction of the GLPI system in the State Budgetary Educational Establishment of Secondary School No. 655 (State Budgetary Educational Institution Secondary School No. 655) with the subsequent maintenance of the implemented solution.
High-density biocompatible hydrogels for in-vivo gastric acid relocation
Creators: name: Earl, Emily Elizabeth
Publisher: name: University of British Columbia
Year: 2023

description: Over the past 30 years, treatments for heartburn have primarily remained unchanged. Current medication focuses on increasing the pH of gastric reflux by altering the overall pH of gastric fluid. This is accomplished by using neutralizing agents or by impairing the body’s ability to produce gastric acid. While these methods are effective at providing symptom management, they can cause undesired side effects and do not specifically target the gastric acid pocket: a highly acidic layer of gastric acid that remains stagnant at the top of the stomach. This thesis explores the development of an alternative technique to treat heartburn that focuses on relocating the contents of the gastric acid pocket rather than neutralizing it. In order to effectively perform this relocation, high-density chitosan-based superporous hydrogels were developed to displace the fluid in the gastric acid pocket by quickly absorbing the contents and sinking to the bottom of the stomach, away from the esophagus. The efficacy of the hydrogels was determined based on four main factors: swelling ability, equilibrium swelling time, swollen density, and biocompatibility. Two main methods of hydrogel formation were compared: the gas blowing method and the freeze-drying method. Within these two methods, a variety of hydrogel formulations were prepared in which the concentrations of polymers, crosslinking agents, and high-density materials were varied to optimize the hydrogel for maximum swelling ability. Biocompatible ceramics such as titanium dioxide and zirconium dioxide were used as the high- density materials in the hydrogel, and their biocompatibility was confirmed through cell cytotoxicity studies. An optimal hydrogel formulation was developed using the freeze-drying procedure paired with density adaptation from zirconium dioxide. This formulation is capable of swelling more than 25 times its initial mass in simulated gastric fluid while maintaining a swollen density higher than that of gastric content. With this swelling ability, an estimated amount of 4 grams of hydrogel material would be required to relocate the entirety of the gastric acid pocket, outlining the potential of this technique for further study regarding heartburn management.
title: ÐÐ¸Ð·Ð°Ð¹Ð½-Ð¿ÑÐ¾ÐµÐºÑ Ð¸Ð½ÑÐµÑÐ°ÐºÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¸Ð»Ð¾Ð¶ÐµÐ½Ð¸Ñ Ð´Ð»Ñ Ð°Ð½ÑÐ¸ÐºÐ°ÑÐµ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Design project of an interactive application for anti-cafe
Creators: name: Ð¥Ð¾Ð¼ÑÐ¸Ðº, ÐÐ»Ð¸Ð·Ð°Ð²ÐµÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: Ð´Ð¸Ð·Ð°Ð¹Ð½
Ð¿ÑÐ¸Ð»Ð¾Ð¶ÐµÐ½Ð¸Ðµ
Ð¿ÑÐ¾ÑÐ¾ÑÐ¸Ð¿
ÑÐºÑÐ°Ð½
Ð¸Ð½ÑÐµÑÑÐµÐ¹Ñ
design
application
prototype
screen
interface

description: Ð¢ÐµÐ¼Ð° Ð²ÑÐ¿ÑÑÐºÐ½Ð¾Ð¹ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ: Â«ÐÐ¸Ð·Ð°Ð¹Ð½-Ð¿ÑÐ¾ÐµÐºÑ Ð¸Ð½ÑÐµÑÐ°ÐºÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¸Ð»Ð¾Ð¶ÐµÐ½Ð¸Ñ Ð´Ð»Ñ Ð°Ð½ÑÐ¸ÐºÐ°ÑÐµÂ».Ð¦ÐµÐ»ÑÑ Ð´Ð¸Ð¿Ð»Ð¾Ð¼Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ ÑÐ²Ð»ÑÐµÑÑÑ ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ðµ Ð¿ÑÐ¾ÑÐ¾ÑÐ¸Ð¿Ð° Ð¸Ð½ÑÐµÑÐ°ÐºÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð¼Ð¾Ð±Ð¸Ð»ÑÐ½Ð¾Ð³Ð¾ Ð¿ÑÐ¸Ð»Ð¾Ð¶ÐµÐ½Ð¸Ñ Ð´Ð»Ñ Ð°Ð½ÑÐ¸ÐºÐ°ÑÐµ Ð² Ð°Ð·Ð¸Ð°ÑÑÐºÐ¾Ð¹ ÑÐµÐ¼Ð°ÑÐ¸ÐºÐµ.Ð ÑÐ¾Ð´Ðµ Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ð½Ð¾Ð¹ Ð²ÑÐ¿ÑÑÐºÐ½Ð¾Ð¹ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ ÑÐµÑÐ°Ð»Ð¸ÑÑ ÑÐ»ÐµÐ´ÑÑÑÐ¸Ðµ Ð·Ð°Ð´Ð°ÑÐ¸:ÐÑÐ¾Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°ÑÑ Ð¸ Ð²ÑÑÐ²Ð¸ÑÑ Ð°ÐºÑÑÐ°Ð»ÑÐ½ÑÐµ ÑÐµÐ½Ð´ÐµÐ½ÑÐ¸Ð¸ UX/UI Ð´Ð¸Ð·Ð°Ð¹Ð½Ð°;Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°ÑÑ ÑÐ¸ÑÐ¼ÐµÐ½Ð½ÑÐ¹ ÑÑÐ¸Ð»Ñ Ð´Ð»Ñ Ð°Ð½ÑÐ¸ÐºÐ°ÑÐµ Ð² Ð°Ð·Ð¸Ð°ÑÑÐºÐ¾Ð¹ ÑÐµÐ¼Ð°ÑÐ¸ÐºÐµ;Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°ÑÑ Ð¿ÑÐ¾ÑÐ¾ÑÐ¸Ð¿ Ð¿ÑÐ¸Ð»Ð¾Ð¶ÐµÐ½Ð¸Ñ Ð´Ð»Ñ Ð°Ð½ÑÐ¸ÐºÐ°ÑÐµ.Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ ÑÐ°Ð±Ð¾ÑÑ Ð±ÑÐ» ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½ Ð¿ÑÐ¾ÑÐ¾ÑÐ¸Ð¿ Ð¸Ð½ÑÐµÑÐ°ÐºÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð¼Ð¾Ð±Ð¸Ð»ÑÐ½Ð¾Ð³Ð¾ Ð¿ÑÐ¸Ð»Ð¾Ð¶ÐµÐ½Ð¸Ñ Ð´Ð»Ñ Ð°Ð½ÑÐ¸ÐºÐ°ÑÐµ Ð² Ð°Ð·Ð¸Ð°ÑÑÐºÐ¾Ð¹ ÑÐµÐ¼Ð°ÑÐ¸ÐºÐµ.
description: The subject of the final bachelor's graduate qualification work is Â«Design project of an interactive application for anti-cafeÂ».The aim of the study is to creation of a prototype of an interactive mobile application for an anti-cafe with an Asian theme.In the course of the presented final qualification work, the following tasks were solved:Analyze and identify current trends in UX / UI design;Develop a corporate identity for an Asian-themed anti-cafe;Develop a prototype app for anti-cafe.As a result of the work, a prototype of an interactive mobile application for an Asian-themed anti-cafe was developed.
Mössbauer spectroscopy, anti-tubercular activity, docking, and HSA binding studies of Fe (III) complexes of selenosemicarbazones
Creators: name: Malhi, Rinku
name: Singh, Iqubal
name: Mir, Irtiqa Ashraf
name: Kubrin, Stanislav P.
name: Savci, Ahmet
name: Sharma, Rekha
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Physiology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology

description: Reaction of cyclohexanone selenosemicarbazone (Hcysesc), 2-furfural selenosemicarbazone (2-Hfursesc), 1-methyl isatinselenosemicarbazone (1-Hmeistsesc), 3-indole selenosemicarbazone (3-Hinsesc), and 3-acetyl indole selenosemicarbazones with iron(III) acetate in 3: 1 (L: M) yielded complexes of stoichiometry, [Fe(L)3] (L = anionic form of cysesc 1; 2-fursesc 2; 5-ClHinsesc) 5, 1-meistsesc 6; 3-insesc 7; 3-acinsesc 8), whereas with 2-thiophene selenosemicarbazoe (2-Hthiosesc) and N-methyl-2-pyrrole selenosemicarbazone (N-Hmepysesc) formed complexes, [Fe(2-thiosesc)2](CH3COO) 3 and [Fe(N-mepysesc)2](CH3COO) 4, respectively. Complexes were characterized using elemental analysis, IR, and mass and Mössbauer spectroscopy. Isomer shift and quadrupole splitting of major species in 1, 2, 5–8 indicates high-spin Fe(III) in octahedral environment, whereas data supports coordination number four in 3 and 4. VSM analysis of complexes indicates that iron in these complexes is magnetically soft. All the complexes were tested for their anti-tubercular and antioxidant activities. The better ferric reducing antioxidant power of 3 (11.96 μg TE/mL) and 5 (16.56 μg TE/mL) can be correlated with the geometry or their coordination numbers. Results of anti-microbial activity showed a significant enhancement in the activity of 2, 4, 5, and 7 as compared to free ligands that are well supported by HSA binding studies and molecular modeling.
Characterization of the Livestock Production Systems and the Potential of Feed-based Interventions for Improving Livestock Productivity in Cheborgei, Roret and Buret Division in Kericho County (Kenya)
Creators: name: Wafula, Sylvia
name: Kirui, Josephine
name: Lukuyu, Ben
Publisher: name: Gates Open Research
Year: 2019

description: Characterization of the Livestock Production Systems and the Potential of Feed-based Interventions for Improving Livestock Productivity in Cheborgei, Roret and Buret Division in Kericho County (Kenya)
Super-Polynomial Quantum Speed-ups for Boolean Evaluation Trees with Hidden Structure
Creators: name: Zhan, Bohua
name: Kimmel, Shelby
name: Hassidim, Avinatan
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We give a quantum algorithm for evaluating a class of boolean formulas (such as NAND trees and 3-majority trees) on a restricted set of inputs. Due to the structure of the allowed inputs, our algorithm can evaluate a depth $n$ tree using $O(n^{2+\logω})$ queries, where $ω$ is independent of $n$ and depends only on the type of subformulas within the tree. We also prove a classical lower bound of $n^{Ω(\log\log n)}$ queries, thus showing a (small) super-polynomial speed-up.
description: 30 pages, 2 figures, v3: clarified exposition, matches journal reference
Epigenetic dysregulation in lymphoid leukemias
Creators: name: Islam, Rashedul
Publisher: name: University of British Columbia
Year: 2023

description: Epigenetic modification to DNA and the histone proteins that package it maintains genome stability and helps to define the transcription program within a cell. Epigenetic programming is a dynamically regulated process essential for normal differentiation including in the blood system, a process known as hematopoiesis. Failures in normal epigenetic programming, driven by genetic mutations to, or changes in expression of, epigenetic modifiers are recurrently observed in specific blood cancers including leukemia. How epigenomic dysregulation contributes to transformation in leukemia is poorly understood and the focus of this thesis. T-cell acute lymphoblastic leukemia (T-ALL) and B-cell chronic lymphocytic leukemia (CLL) arise from the lymphoid hematopoietic lineages and are defined by the block of maturation of T- and B-cells, respectively. To characterize epigenetic dysregulation associated with T-ALL and CLL, I performed an integrative analysis spanning multiple layers of epigenomic and transcriptomic datasets generated from sorted primary leukemic blasts and cell line models. My analysis revealed a common theme of enhancer reprogramming driving an oncogenic transcription program in these leukemias. Gain-of-function mutations to NOTCH1 are amongst the most frequent genetic lesions in T-ALL. In NOTCH1 activated T-ALL cell lines, I found that Runt-related transcription factor 1 (RUNX1), a key hematopoietic transcription factor, regulates the occupancy of the active enhancer mark (H3K27ac) genome-wide. I showed that RUNX1 is required for NOTCH1 to acetylate H3K27 residues and to co-regulate the expression of known NOTCH1 target genes including MYC, NOTCH3, HES4, and DTX1. Using a bioinformatic pipeline I developed, I classified CLL patients into IGHV subtypes using RNA-seg. In the epigenomic profiles generated from primary CLL blasts classified by my pipeline, I observed that CLL has a unique landscape of enhancer marks (H3K27ac and H3K4me1) compared to normal B-cell counterparts. De novo gain of CLL-specific enhancers contributes to the generation of super-enhancers and clusters of neighboring enhancers associated with the expression of proto-oncogenes including BCL2, LEF1, FGR, and CBFA2T3. My analysis further showed differences in DNA methylation at CLL-specific enhancers classify CLL samples into two novel clinical subgroups, independent of IGHV subtype.
A New Evolutionary Phase of Supernova Remnant 1987A
Creators: name: Park, Sangwook
name: Zhekov, Svetozar A.
name: Burrows, David N.
name: Racusin, Judith L.
name: Dewey, Daniel
name: McCray, Richard
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We have been monitoring the supernova remnant (SNR) 1987A with {\it Chandra} observations since 1999. Here we report on the latest change in the soft X-ray light curve of SNR 1987A. For the last $\sim$1.5 yr (since day $\sim$8000), the soft X-ray flux has significantly flattened, staying (within uncertainties) at $f_{\rm X}$ $\sim$ 5.7 $\times$ 10$^{-12}$ erg cm$^{-2}$ s$^{-1}$ (corresponding to $L_{\rm X}$ $\sim$ 3.6 $\times$ 10$^{36}$ erg s$^{-1}$) in the 0.5--2 keV band. This remarkable change in the recent soft X-ray light curve suggests that the forward shock is now interacting with a decreasing density structure, after interacting with an increasing density gradient over $\sim$10 yr prior to day $\sim$8000. Possibilities may include the case that the shock is now propagating beyond a density peak of the inner ring. We briefly discuss some possible implications on the nature of the progenitor and the future prospects of our {\it Chandra} monitoring observations.
description: 11 pages, 2 tables, 1 color figure, Accepted by ApJ Letters
title: Assessing classical swine fever disease control measures using an individual-based model
Creators: name: Lange, M.
name: Kramer-Schadt, S.
name: Thulke, H.-H.
Publisher: name: Julius Kühn-Institut
Year: 2011
Subjects: subject: Classical Swine Fever
subject: disease control
subject: epidemiological modelling
subject: individual-based model
subject: oral mass immunization
subject: uncertainty
subject: virulence

description: Julius-Kühn-Archiv; 432; 203
Synthesis, characterization and photophysical properties of some water soluble Zn(II) azide complexes with (E)-2,4-dimethoxy-N-((pyridin-2-yl)methylene)benzenamine derived from 2-pyridinecarboxaldehyde
Creators: name: Kundu, Sajal
name: Debbarma, Pirkha
name: Roy, Subhadip
name: Sieroń, Lesław
name: Dinda, Soumitra
name: Maniukiewicz, Waldemar
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Biophysics
Biochemistry
Physical Sciences not elsewhere classified
Cell Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified

description: Five new zinc(II) azide complexes with the composition [Zn(N3)2(Ln)], where Ln = (E)-2,4-dimethoxy-N-((pyridin-2-yl)methylene)benzenamine, are reported herein. The complexes were characterized using UV-vis, fluorescence, IR, and 1H NMR spectroscopy, along with elemental analysis. The single-crystal structural analysis of compound 1 is presented. The mononuclear Zn(II) complex crystallized in the monoclinic system with the centrosymmetric space group P21/n. The asymmetric unit of complex 1 consists of two crystallographically independent molecules with quite similar geometries. The five-coordination geometry of the Zn(II) ions in 1 is irregular, best described as halfway between trigonal bipyramidal and square pyramidal geometries. Efforts to obtain single crystals of compounds 2–5 suitable for X-ray crystal structure analysis were unsuccessful. However, based on spectroscopic data and the structures of related zinc(II) complexes reported in the literature, complex 2 is proposed to have a geometry similar to that of complex 1, and complexes 3–5 are anticipated to have a four-coordinated tetrahedral geometry. All complexes were obtained in moderate-to-good yields and behave as non-electrolytes in acetonitrile solution. UV-vis and fluorescence spectral studies of complexes 1–5 indicate ligand-to-ligand (intra-ligand, π-π*) charge transfer transitions.
Localization of light on a cone: theoretical evidence and experimental demonstration for an optical fiber
Creators: name: Sumetsky, M.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The classical motion at a conical surface is bounded at one (narrower) side of the cone and unbounded at the other. However, it is shown here that a dielectric cone with a small half-angle gamma can perform as a high Q-factor optical microresonator which completely confines light. The theory of the discovered localized conical states is in excellent agreement with experimental data. It provides both a unique approach for extremely accurate local characterization of optical fibers (which usually have gamma ~10^-5 or less) and a new paradigm in the field of high Q-factor resonators.
High resolution spectroscopy of the three dimensional cosmic web with close QSO groups
Creators: name: Cappetta, M.
name: D'Odorico, V.
name: Cristiani, S.
name: Saitta, F.
name: Viel, M.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We study the three-dimensional distribution of matter at z~2 using high resolution spectra of QSO pairs and simulated spectra drawn from cosmological hydro-dynamical simulations. We present a sample of 15 QSOs, corresponding to 21 baselines of angular separations evenly distributed between ~1 and 14 arcmin, observed with the Ultraviolet and Visual Echelle Spectrograph (UVES) at the European Southern Observatory-Very Large Telescope (ESO-VLT). The observed correlation functions of the transmitted flux in the HI Lya forest transverse to and along the line of sight are in agreement, implying that the distortions in redshift space due to peculiar velocities are relatively small and - within the relatively large error bars - not significant. The clustering signal is significant up to velocity separations of ~300 km/s, corresponding to about 5 h^{-1} comoving Mpc. Compatibility at the 2 sigma level has been found both for the Auto- and Cross-correlation functions and for the set of the Cross correlation coefficients. The analysis focuses in particular on two QSO groups of the sample. Searching for alignments in the redshift space between Lya absorption lines belonging to different lines of sight, it has been possible to discover the presence of a wide HI structures extending over about ten Mpc in comoving space, and give constraints on the sizes of two cosmic under-dense regions in the intergalactic medium.
description: Accepted by MNRAS, version matching the published one