cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Adverse clinical outcomes associated with sickle cell trait at high altitude.
Creators: name: Patell, Rushad
name: Key, Nigel S
name: Osataphan, Soravis
name: Stafford, Katherine A
Publisher: name: Ferrata Storti Foundation (Haematologica)
Year: 2024

description: Sickle cell trait (SCT) is a prevalent condition affecting more than 300 million individuals
worldwide. Although formerly regarded as a benign carrier state, with complications rarely
occurring outside of high-altitude or extreme physiologic conditions, recent population-level
data has revealed an increased risk for chronic kidney disease (CKD) and pulmonary
embolism (PE) in general populations. In this study, we sought to evaluate whether chronic,
moderately high altitude exposure can increase the breadth and severity of SCT
complications compared to sea-level cohorts. We used data from Colorado, which has the
highest mean elevation of any State in the USA (2,070 m). We found that the risk for known
SCT complications such as CKD and PE, as well as other clinical outcomes in which prior
evidence was either weak or mixed, were significantly increased. In the latter category,
adverse pregnancy outcomes including pre-eclampsia and intra-uterine death were
particularly notable. The strength of the associations observed in this study generally
exceeds prior reports and suggests that SCT patients living at high-altitude are at greater
risk for morbidity than their sea-level counterparts.
Coupled Cluster Method Calculations Of Quantum Magnets With Spins Of General Spin Quantum Number
Creators: name: Farnell, D. J. J.
name: Bishop, R. F.
name: Gernoth, K. A.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We present a new high-order coupled cluster method (CCM) formalism for the ground states of lattice quantum spin systems for general spin quantum number, $s$. This new ``general-$s$'' formalism is found to be highly suitable for a computational implementation, and the technical details of this implementation are given. To illustrate our new formalism we perform high-order CCM calculations for the one-dimensional spin-half and spin-one antiferromagnetic {\it XXZ} models and for the one-dimensional spin-half/spin-one ferrimagnetic {\it XXZ} model. The results for the ground-state properties of the isotropic points of these systems are seen to be in excellent quantitative agreement with exact results for the special case of the spin-half antiferromagnet and results of density matrix renormalisation group (DMRG) calculations for the other systems. Extrapolated CCM results for the sublattice magnetisation of the spin-half antiferromagnet closely follow the exact Bethe Ansatz solution, which contains an infinite-order phase transition at $Δ=1$. By contrast, extrapolated CCM results for the sublattice magnetisation of the spin-one antiferromagnet using this same scheme are seen to go to zero at $Δ\approx 1.2$, which is in excellent agreement with the value for the onset of the Haldane phase for this model. Results for sublattice magnetisations of the ferrimagnet for both the spin-half and spin-one spins are non-zero and finite across a wide range of $Δ$, up to and including the Heisenberg point at $Δ=1$.
description: 5 Figures. J. Stat. Phys. 108, p. 401 (2002)
Collective in-plane magnetization in a 2D XY macrospin system within the framework of generalized Ott-Antonsen theory
Creators: name: Tyulkina, Irina V.
name: Goldobin, Denis S.
name: Klimenko, Lyudmila S.
name: Poperechny, Igor S.
name: Raikher, Yuriy L.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: The problem of magnetic transitions between the low-temperature (macrospin ordered) phases in 2D XY arrays is addressed. The system is modeled as a plane structure of identical single-domain particles arranged in a square lattice and coupled by the magnetic dipole-dipole interaction; all the particles possess a strong easy-plane magnetic anisotropy. The basic state of the system in the considered temperature range is an antiferromagnetic (AF) stripe structure, where the macrospins (particle magnetic moments) are still involved in thermofluctuational motion: the superparamagnetic blocking $T_b$ temperature is lower than that ($T_\text{af}$) of the AF transition. The description is based on the stochastic equations governing the dynamics of individual magnetic moments, where the interparticle interaction is added in the mean field approximation. With the technique of a generalized Ott-Antonsen theory, the dynamics equations for the order parameters (including the macroscopic magnetization and the antiferromagnetic order parameter) and the partition function of the system are rigorously obtained and analysed. We show that inside the temperature interval of existence of the AF phase, a static external field tilted to the plane of the array is able to induce first order phase transitions from AF to ferromagnetic state; the phase diagrams displaying stable and metastable regions of the system are presented.
description: 18 pages, 3 figures
The Biodiversity Intactness Index: Flyer for the World Biodiversity Forum
Creators: name: Purvis, Andy
Publisher: name: figshare
Year: 2020
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 50202 Conservation and Biodiversity

description: Short flyer outlining the the Biodiversity Intactness Index as produced by the PREDICTS project. To explore the projections of BII displayed in this flyer in more detail, see here: https://adriana-de-palma.shinyapps.io/ssp_explore/. To see a more detailed explanation of the statistical methods, see here: https://adrianadepalma.github.io/BII_tutorial/bii_example.html
Challenges and opportunities for enhancing groundwater data access and usability in low- and middle-income countries: insights and recommendations from WaSH researchers and practitioners
Creators: name: Kelly, Emma
name: Landa, Silvia
name: Gregory, Allison
name: Samo, June
name: McManus, Catherine
name: Sobsey, Mark D.
name: Lopez, Jason
name: Burrows, Geraint
name: Muthike, Denis M.
name: Salzberg, Aaron
name: Cronk, Ryan
Publisher: name: IWA Publishing
Year: 2024

description: Groundwater provides more than half of all water for drinking and irrigation worldwide. Monitoring and managing groundwater resources is essential to achieve the Sustainable Development Goals. However, groundwater resources need to be better monitored. We explored practical approaches to improve groundwater monitoring for informed decision-making, focusing on low- and middle-income country settings. Case studies from a 2023 UNC Water and Health Conference side event highlighted innovative approaches, including open-source data modeling, groundwater monitoring in humanitarian contexts, and using in situ sensors to monitor drought resilience. The case studies described field data integration, remote sensing, and technology (e.g., Modflow-USG, ModelMuse, Drought Resilience Impact Platform). Barriers to groundwater data use were identified by side event participants, including inadequate data access, insufficient collaboration and leadership, and challenges in integrating diverse data and technology. Side event recommendations included creating a central groundwater monitoring data repository, building greater hydrogeology capacity in the WaSH sector, and increasing funding for data collection and monitoring. We urge government leaders to develop regulations and build internal capacity for sustainable groundwater management. This comprehensive approach aims to address challenges and promote informed decision-making for the long-term sustainability of groundwater resources.
Bictegravir/emtricitabine/tenofovir alafenamide in adults with HIV‐1 and end‐stage kidney disease on chronic haemodialysis
Creators: name: Dejesus, Edwin
name: Osiyemi, Olayemi
name: Arora, Priyanka
name: Ramgopal, Moti
name: Hindman, Jason T.
name: Eron, Joseph J.
name: Wilkin, Aimee
name: Blair, Christiana
name: Mckellar, Mehri
name: Slim, Jihad
Publisher: name: Wiley
Year: 2024

description: INTRODUCTION: Treatment for people with HIV-1 and end-stage kidney disease (ESKD) on haemodialysis (HD) has previously required complex dose-adjusted regimens, with limited data on the use of a single-tablet regimen in this population. Our aim was to assess the efficacy and safety of once-daily bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) and to evaluate the pharmacokinetics of bictegravir (BIC) in adults with HIV-1 and ESKD on HD.
METHODS: We performed an open-label extension (OLE) of an open-label, multicentre, single-group phase 3b study (NCT02600819) of adults with ESKD on HD and HIV-1 with virological suppression. Participants switched to elvitegravir/cobicistat/F/TAF (E/C/F/TAF) 150/150/200/10 mg for 96 weeks, following which a subgroup of US participants entered an OLE phase in which they switched to B/F/TAF 50/200/25 mg for 48 weeks, returning for study visits at weeks 4 and 12, and every 12 weeks thereafter. Study assessments included virological response, safety and pharmacokinetic analysis of BIC.
RESULTS: Ten participants entered the OLE (median age, 55 years). Virological suppression (HIV-1 RNA <50 copies/mL) was maintained in all participants over 48 weeks of B/F/TAF treatment. B/F/TAF was well tolerated, with no treatment discontinuations. Mean BIC trough concentrations were lower than those previously reported for people with HIV-1 with normal kidney function, but remained four- to seven-fold higher than the established protein-adjusted 95% effective concentration against wild-type HIV-1.
CONCLUSION: These findings support the use of the once-daily B/F/TAF single-tablet regimen for people with HIV-1 and ESKD on HD. This regimen offers a convenient treatment option for this population as it reduces the need for dose adjustment, eases pill burden and avoids potential drug-drug interactions associated with alternatives that may impact individuals on multiple medications or awaiting transplantation.
Symmetric mixtures of pusher and puller microswimmers behave as noninteracting suspensions
Creators: name: Bárdfalvy, Dóra
name: Anjum, Shan
name: Nardini, Cesare
name: Morozov, Alexander
name: Stenhammar, Joakim
Publisher: name: arXiv
Year: 2020
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Biological Physics (physics.bio-ph)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: Suspensions of rear- and front-actuated microswimmers immersed in a fluid, known respectively as ``pushers'' and ``pullers'', display qualitatively different collective behaviours: beyond a characteristic density, pusher suspensions exhibit a hydrodynamic instability leading to collective motion known as active turbulence, a phenomenon which is absent for pullers. In this Letter, we describe the collective dynamics of a binary pusher--puller mixture using kinetic theory and large-scale particle-resolved simulations. We derive and verify an instability criterion, showing that the critical density for active turbulence moves to higher values as the fraction $χ$ of pullers is increased and disappears for $χ\geq 0.5$. We then show analytically and numerically that the two-point hydrodynamic correlations of the 1:1 mixture are equal to those of a suspension of noninteracting swimmers. Strikingly, our numerical analysis furthermore shows that the full probability distribution of the fluid velocity fluctuations collapses onto the one of a noninteracting system at the same density, where swimmer--swimmer correlations are strictly absent. Our results thus indicate that the fluid velocity fluctuations in 1:1 pusher--puller mixtures are exactly equal to those of the corresponding noninteracting suspension at any density, a surprising cancellation with no counterpart in equilibrium long-range interacting systems.
Observation of shot-noise-induced asymmetry in the Coulomb blockaded Josephson junction
Creators: name: Lindell, R. K.
name: Delahaye, J.
name: Sillanpaa, M. A.
name: Heikkila, T. T.
name: Sonin, E. B.
name: Hakonen, P. J.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We have investigated the influence of shot noise on the IV-curves of a single mesoscopic Josephson junction. We observe a linear enhancement of zero-bias conductance of the Josephson junction with increasing shot noise power. Moreover, the IV-curves become increasingly asymmetric. Our analysis on the asymmetry shows that the Coulomb blockade of Cooper pairs is strongly influenced by the non-Gaussian character of the shot noise.
description: 4 pages, 5 figures, RevTEX
title: The validity of the Telic Dominance Scale
Creators: name: Murgatroyd, Stephen John
Publisher: name: The Open University
Year: 1984

description: The Telic Dominance Scale (TDS) is a 42 item pencil and paper psychometric instrument intended to measure the extent to which a person is seriousminded, planning orientated, arousal avoiding and telic or paratelic dominant. Using test related reliability methods, this study demonstrates that the TDS is a reliable instrument over a variety of time intervals up to one year. Reviewing a variety of studies, including a number in which the author was the sole or a collaborative researcher, it is suggested that the TDS is a valid instrument in the sense in which 'validity ' is used in the psychometric tradition. Some doubts concerning the phenomenological grounding of the TDS are examined in the context of a multi-method validation study. Using a principal components analysis with varimax rotation, a factor analysis of TDS responses suggests that the factor structure of responses does not match the structure implied in the sub-scale structure in the TDS. The implications of this finding are fully discussed.
„Ist jetzt alles wieder normal?“ Ehrenamtliche Mitarbeit in der Stadtbibliothek Melle in Zeiten der Corona-Pandemie
Creators: name: Koop, Ulrike
Publisher: name: Humboldt-Universität zu Berlin
Year: 2021
Subjects: subject: Ehrenamt
subject: Freiwilliges Engagement
subject: Öffentliche Bibliothek
subject: Corona-Pandemie
subject: Volunteering
subject: civic involvement
subject: public library
subject: corona pandemic
subject: 020 Bibliotheks- und Informationswissenschaften

description: Der Artikel beschreibt den Umfang und die Organisation ehrenamtlicher Mitarbeit in einer Mittelstadtbibliothek sowie deren (bisherige) Veränderung durch die Corona-Pandemie.
description: The article describes the scope and organization of voluntary work in a medium-sized public library and how it has changed (so far) due to the corona pandemic.
Proposed Changes Would Increase the Cost and Decrease the Benefit of Listing Species as Endangered
Creators: name: Sims, Charles
name: Palikhe, Himadri
name: Sims, Charles
name: Palikhe, Himadri
Publisher: name: Unknown
Year: 2019
Subjects: subject: Environmental Economics and Policy
subject: Institutional and Behavioral Economics
subject: Conservation
subject: Endangered species
subject: Natural capital
subject: Real options

description: The most dramatic and controversial of the recent proposed changes to the Endangered Species Act involves the regulations surrounding listing and delisting species. Based on past economic analyses, we find that these proposed changes will likely increase the cost and decrease the benefit of species protection.
Biological and prognostic relevance of epigenetic regulatory genes in high-grade gliomas (HGGs)
Creators: name: Hinton, Andrew
name: Kesari, Santosh
name: Xiu, Joanne
name: Sumrall, Ashley Love
name: Aulakh, Sonikpreet
name: Darabi, Sourat
name: Ashley, David M
name: Glantz, Michael J
name: Sengupta, Soma
name: Spetzler, David
name: Demeure, Michael J
Publisher: name: Oxford University Press (OUP)
Year: 2024

description: Background High-grade gliomas (HGGs) are the most aggressive type of gliomas and have the poorest outcomes. Chromatin remodeling (CR) genes have been implicated in multiple oncogenic pathways in numerous cancer types. In gliomagenesis, CR genes have been implicated in regulating stemness of glioma cells, the tumor microenvironment (TME), and resistance to therapies.   Methods We performed molecular profiling of 4244 HGGs and evaluated associations of CR mutations with other cancer related biomarkers, infiltration by immune cells, and immune gene expression. We also evaluated the association between CR mutations and survival in IDH WT HGG patients.   Results Nearly 10% of HGGs carry mutations in CR genes, with higher prevalence (15%) in HGGs with IDH mutations. Analysis of co-occurrence with other biomarkers revealed that CR-mutated HGGs possess favorable genetic alterations which may have prognostic value. CR-mutated HGGs with wild type IDH demonstrated colder TME and worse OS overall compared to the CR-wild type HGGs.   Conclusions Our study reveals the prognostic effects of CR mutations in HGG and points to several biomarker candidates that could suggest sensitivity to emerging therapeutic strategies.
Korea-Chile FTA Agreement and Policy Implications
Creators: name: Lim, Jeongbin
name: Lim, Jeongbin
Publisher: name: Unknown
Year: 2004
Subjects: subject: International Relations/Trade
subject: Free Trade Agreement
subject: Market Liberalization
subject: Agricultural Trade
subject: Chile
subject: Tariff Elimination

description: This study analyses the trends of agricultural trade between Korea and Chile after the effectuation of bilateral FTA, and seeks to the policy implication on the future FTA agreements with other countries. The value of trade between Korea and Chile is increased after the launch of FTA. As our expectation, the export of Korean manufactured goods such as automobiles, wireless phone, TV and video camera has sharply been increased through the effects of tariff elimination whereas the import of Chilean agricultural products such as wine, pork, kiwi, and fruit preparation has been increased. However the import of Chilean fresh fruit such as grape and peach has not been greatly increased rather than prior expectation. It is mainly because of seasonal tariff measure for grape and plant quarantine for peach and other fruits. Particularly the negative impacts on the Korean fruit industry of FTA with Chile will be shown in the mid-term (3∼10years) according to the effects of extinguishing quarantine measure. Therefore this paper overviews the process of mid-term effects of Korea-Chiles FTA on agricultural sector and presents the Korean FTA strategies in order to minimize the negative impacts on agricultural sector.
Production of Enhanced Beam Halos via Collective Modes and Colored Noise
Creators: name: Sideris, Ioannis V.
name: Bohn, Courtlandt L.
Publisher: name: arXiv
Year: 2004
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: We investigate how collective modes and colored noise conspire to produce a beam halo with much larger amplitude than could be generated by either phenomenon separately. The collective modes are lowest-order radial eigenmodes calculated self-consistently for a configuration corresponding to a direct-current, cylindrically symmetric, warm-fluid Kapchinskij-Vladimirskij equilibrium. The colored noise arises from unavoidable machine errors and influences the internal space-charge force. Its presence quickly launches statistically rare particles to ever-growing amplitudes by continually kicking them back into phase with the collective-mode oscillations. The halo amplitude is essentially the same for purely radial orbits as for orbits that are initially purely azimuthal; orbital angular momentum has no statistically significant impact. Factors that do have an impact include the amplitudes of the collective modes and the strength and autocorrelation time of the colored noise. The underlying dynamics ensues because the noise breaks the Kolmogorov-Arnol'd-Moser tori that otherwise would confine the beam. These tori are fragile; even very weak noise will eventually break them, though the time scale for their disintegration depends on the noise strength. Both collective modes and noise are therefore centrally important to the dynamics of halo formation in real beams.
description: For full resolution pictures please go to http://www.nicadd.niu.edu/research/beams/
University student retention and the international student : engaging universities in student success programming
Creators: name: Verkerk, Kathryn
Publisher: name: The University of British Columbia
Year: 2017

description: The Government of Canada has prioritized international students1 as an important avenue for immigration; as such, the government plans to double the number of international students entering Canada by 2022 (Government of Canada, 2010). Likewise, the Province of British Columbia, in support of this initiative, would like 50% of Canada’s international students to be studying at an institution within the province (British Columbia Ministry of Higher Education, 2012). As a result, British Columbia’s universities, such as the University of British Columbia (UBC) and Simon Fraser University (SFU), are pushing to increase their enrollment of international students by 2020. Although the enrollment of international students is on the rise, many universities have not differentiated their academic and social services in support of the unique needs of international students in academic difficulty. As institutions invest more resources in recruiting increasing numbers of international students, “it is in their best interest to retain these students and gain the full educational, cultural, and economical benefits of an internationally diverse student body” (Mamiseishvili, 2012, p. 2). Student retention is much more cost effective than recruiting new students; therefore, universities should focus equal attention on retention, rather than limiting their scope to recruitment and admission. This paper will explore the support services available to international students, specifically those in academic difficulty, with an analysis of student success programs. Through a detailed literature review, I will evaluate how universities support their international student population and the types of student success programs that exist for those in academic difficulty (i.e. on academic probation and/or required to withdraw). I will conclude by tracing the history of SFU’s Back on Track program and suggest an institutional framework, which is informed by the literature on international student retention.
Petrel geological model of the Groningen gas field, the Netherlands
Publisher: name: Utrecht University
Year: 2020
Subjects: subject: Natural Sciences - Earth and related environmental sciences (1.5)
subject: Groningen gas field
subject: Reservoir
subject: Model
subject: Petrel
subject: Geology
subject: FOS: Earth and related environmental sciences
subject: Faults
subject: NAM
subject: EPOS-NL

description: Geological model and data of the Groningen gas field, the Netherlands, developed by the Nederlandse Aardolie Maatschappij (NAM) and distributed by the Dutch research infrastructure of solid earth sciences, EPOS-NL. The static model helps geoscientists to develop stratigraphic and structural understanding of the Groningen gas reservoir, allowing to move seamlessly from 2D maps to 3D models and so to provide accuracy throughout the exploration, development, and (post-)production stages. Before usage, please note the following points:

• This model was developed in and is compatible with Petrel software, version 2018
• The model has taken years of expert development. Please use only if you are a skilled Petrel user.
• This model includes well log and seismic data that is also openly accessible on the NLOG webpage.
• This data publication includes a RESCUE 3d grid data export of the Petrel model. The RESCUE data can be read by many open source software.
• Please reference use of this data publication as: NAM (2020). Petrel geological model of the Groningen gas field, the Netherlands. Open access through EPOS-NL. Yoda data publication platform Utrecht University. https://doi.org/10.24416/UU01-1QH0MW
• EPOS-NL takes genuine interest in which parties use the model. If you intend on using the model, please let us know by emailing to: info@epos-nl.nl • If you encounter problems in accessing the model, please contact EPOS-NL: info@epos-nl.nl
• For technical questions relating to model use, please contact Dr. Fred Beekman at Utrecht University: fred.beekman@uu.nl
Projektbericht: Erfahrungen mit bürgerschaftlichem Engagement in der Stadtbibliothek Aachen am Beispiel der ‚Dialog in Deutsch‘-Gesprächsrunden für Zugewanderte
Creators: name: Lohe, Anne
Publisher: name: Humboldt-Universität zu Berlin
Year: 2021
Subjects: subject: Ehrenamt in Öffentlichen Bibliotheken in Zusammenarbeit mit ausgebildeten hauptamtlichen Mitarbeitenden
subject: Konversationstreffen in Deutsch für Migrant*innen
subject: Veränderungsmanagement
subject: Auswirkungen der Coronapandemie auf das ehrenamtliche Integrationsprojekt
subject: Volunteering in public libraries in cooperation with trained full-time staff
subject: Conversation meeting in German language for immigrants
subject: Change Management
subject: Impact of the Corona pandemic on the voluntary integration project
subject: 020 Bibliotheks- und Informationswissenschaften

description: Die Stadtbibliothek Aachen hat seit 2015 mit den Gesprächsgruppen „Dialog in Deutsch“ ein ehrenamtlich getragenes niederschwelliges Projekt für Zugewanderte in den laufenden Betrieb integriert, das sich am Modell der Bücherhallen Hamburg orientiert. Das Beispiel illustriert das Potential für die Weiterentwicklung von einer traditionell aufgestellten Stadtbibliothek zu einem mit anderen Bildungsträgern vernetzten Kulturzentrum. Zugleich zeigt es Herausforderung und Chancen für Öffentliche Bibliotheken bei der Einbindung ehrenamtlichen Engagements angesichts eines offensichtlichen gesellschaftlichen Bedarfs an Integrationsarbeit. Abschließend beleuchtet ein Blick auf die aktuelle Situation in 2020 die Beeinträchtigung des DiD-Projekts durch die Coronapandemie.
description: Based on the model of the Hamburg public libraries, the Aachen City Library has integrated the discussion groups ‘Dialogue in German’® (DiD), a low-threshold project for immigrants, into its day-to-day operations since 2015. The example illustrates the potential for further development from a traditionally positioned municipal library to a cultural centre networking with other educational institutions. Especially regarding the obvious social need for integration work, the project shows challenges and opportunities for public libraries to integrate voluntary work. Finally, a look at the current situation in 2020 deals with the impact of the Covid-19 pandemic on the DiD project.
Truth and dare: patients dare to tell the truth when using PROMs in clinical practice
Creators: name: Blackford, Amanda L.
name: Snyder, Claire
name: Engelen, Vivian
name: van Rossum, Marion A. J.
name: Grootenhuis, Martha A.
name: Absolom, Kate
name: Luijten, Michiel A. J.
name: Velikova, Galina
name: Basch, Ethan M.
name: Haverman, Lotte
Publisher: name: Springer Nature
Year: 2024

description: Purpose As patient-reported outcome measures (PROMs) are increasingly used in clinical practice for screening, monitoring, and management, the potential for response bias has been raised (e.g., over-reporting problems for attention, under-reporting to avoid treatment changes/discontinuation). We investigated whether patients systematically bias their responses when they know clinicians will review their PROM results. Methods We conducted secondary analyses of three experimental studies evaluating PROMs in adult and pediatric care. Prior to PROM completion, intervention group patients were informed that the results would be shown to their clinicians (“feedback” arm), whereas control group patients were told that their clinicians would not see their responses (“no feedback” arm). Independent sample t-tests compared the “feedback” and “no feedback” arms’ PROM scores at baseline. Effect sizes and 95% confidence intervals were estimated using Cohen’s d statistics with Hedges’ g correction, and effect sizes > 0.50 were considered clinically relevant. Results Across the 29 domains assessed in the three studies, no between-arm differences reached an effect size of ± 0.50. Only 3/29 effect sizes exceeded ± 0.30. The confidence intervals for 14 domains included ± 0.50, with 4 favoring the “no feedback” arm and 10 favoring the “feedback” arm. Two domains reached statistical significance, one favoring the “no feedback” arm and one favoring the “feedback” arm. Conclusion This study does not support the hypothesis that patients systematically bias their PROM responses if they know that clinicians will see their results. These findings support using PROMs in clinical practice as a valid mechanism to promote patient-centered care.
Composite fermions in a wide quantum well in the vicinity of the filling factor 1/2
Creators: name: Drichko, I. L.
name: Smirnov, I. Yu.
name: Suslov, A. V.
name: Kamburov, D.
name: Baldwin, K. W.
name: Pfeiffer, L. N.
name: West, K. W.
name: Galperin, Y. M.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Using acoustic method we study dependences of transverse AC conductance, $σ(ω)$, on magnetic field, temperature and the amplitude of AC electric field in a wide (75 nm) quantum well (QW) structure focusing on the vicinity of the filling factor $ν=1/2$. Measurements are performed in the frequency domain 30-307 MHz and in the temperature domain 20-500 mK. Usually, in wide QW structures closely to $ν=1/2$ the fractional quantum Hall effect (FQHE) regime is realized at some parameters of the sample. However, in our structure, at $ν=1/2$ it is a compressible state corresponding to gas of composite fermions which is observed. This is confirmed by apparent frequency independence and weakly decreasing temperature dependence of $\mathrm{Re}\, σ(ω)$. Comparing the dependences of this quantity on temperature and power of the acoustic wave we conclude that the observed nonlinear behavior of the conductance is compatible with heating of the composite fermions by the acoustic wave. For comparison, we also study the vicinity of $ν= 3/2$ where the FQHE regime is clearly observed.
description: 6 pages, 6 figures
A “rotating menu” of medical uncertainty for families affected by telomere biology disorders: A qualitative interview study
Creators: name: Rising, Camella
name: Majid, Alina
name: Pearce, Emily
name: Gilkey, Melissa B.
name: Shepherd, Rowan Forbes
name: Thompson, Ashley S.
name: Han, Paul K.J.
name: Hutson, Sadie P.
name: Wilsnack, Catherine
name: Brown, Toniya
name: Ribisl, Kurt M.
name: Werner-Lin, Allison
name: Niknafs, Arman
name: Savage, Sharon A.
Publisher: name: Elsevier
Year: 2024

description: Background Medical uncertainty may cause distress and challenge medical decision-making for patients with rare diseases and their caregivers. Few studies have examined the experience and management of medical uncertainty in rare disease and the dynamics of multiple medical uncertainty sources, issues, and management strategies. Objective We explored the experience and management of uncertainty in individuals with telomere biology disorders (TBDs), a set of rare cancer-prone bone marrow failure syndromes, and their caregivers. Design Participants (N=32) in this qualitative-descriptive study were individuals with a TBD (n=17) and/or their caregivers (n=15). We thematically analyzed transcripts to describe the presence and dynamics of medical uncertainty in TBDs using categories from a previously published taxonomy. Results Individuals with TBDs and caregivers described medical uncertainty as a chronic burden embodied amidst a range of interrelated sources and issues. Scientific uncertainty included diagnostic and prognostic ambiguity. Practical uncertainty focused on logistical challenges of building and maintaining medical care teams. Personal uncertainty included difficulty realigning self-identity, goals, and relationship expectations post-diagnosis. Scientific, practical, and personal uncertainty issues were entangled. The rarity of TBDs resulted in limited scientific knowledge, which gave rise to practical and personal uncertainties affecting medical decision-making and relationship formation (e.g., creating trusted care teams where patient knowledge of TBDs may exceed that of clinicians). Participants used multiple strategies for uncertainty management, particularly information-seeking and community-building. However, these management strategies could intensify, rather than resolve, participants’ medical uncertainty. Conclusion In TBDs, medical uncertainty manifests as a network of multiple, interrelated, sources and issues, which require evolving management strategies. Researchers must be mindful that complex, synergistic uncertainty networks contribute to psychosocial challenges in TBDs. Additional research is warranted to address scientific uncertainty in TBDs, including clinical manifestations and underlying biology, and to develop psychosocial interventions that recognize and anticipate evolving uncertainty.
The Reactions and Assessments of the DDA Framework in the US
Creators: name: Kim, Jaesoo
name: Kim, Jaesoo
Publisher: name: Unknown
Year: 2004
Subjects: subject: Agricultural and Food Policy
subject: Doha Development Agenda
subject: framework
subject: domestic support
subject: market access
subject: export competition

description: The WTO/DDA framework for agriculture agreed on August 1, 2004 is very important for all member countries including Korea, although much remains to be negotiated. The views of the U.S. remain important due to its role in the WTO negotiation. Their views will somewhat determine the understanding of the framework. The U.S. sees the framework as a significant achievement along with the farm groups in the U.S., especially in the export subsidy area which requires elimination of all forms of export subsidies. The Korean agricultural sector must also prepare by examining the framework carefully, while modifying strategies for future negotiations and general domestic agricultural programs. In addition, the Korean government must obtain developing country status in continuing its negotiation to receive more favorable treatment in the implementation process.
"He Beheld the Prince of Darkness": Joseph Smith and Diabolism in Early Mormonism 1815-1831
Creators: name: Hepworth, Steven R.
Publisher: name: Utah State University
Year: 2021

description: Joseph Smith published his first known recorded history in the preface to the 1830 edition of the Book of Mormon. In it, he recounted the loss of the earliest portions of the book’s manuscript due to theft in a scheme the future prophet believed was concocted by the devil. Smith claimed to receive a revelation that instructed him on how to overcome the diabolic plot meant to discredit and destroy the Book of Mormon. This was not Smith’s first or last recorded encounter with the devil. He believed the devil was real and that he was engaged in a cosmic battle between God and Satan. Much of Smith’s early prophetic projects were directed at engaging and winning this cosmic battle. This important aspect of Joseph Smith’s religious thought, under-developed in the vast scholarship written about him, is crucial in understanding how he developed his prophetic identity and religious system. This thesis explores the impact Joseph Smith’s diabolism, that is his belief in and encounters with the devil, had on the formation of his prophetic identity, his production of new scripture, and the rise of early Mormonism.
Transonic aeroelasticity: a new perspective from the fluid mode
Creators: name: Gao, Chuanqiang
name: Zhang, Weiwei
Publisher: name: arXiv
Year: 2020
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: Within the transonic regime, the aeroelastic problems exhibit many unique characteristics compared with subsonic and supersonic cases. Although a lot of research has been carried out in this field, the underlying mechanisms of these complex phenomena are not clearly understood yet, resulting in a challenge in the design and use of modern aircraft. This review summarizes the recent investigations on nonclassical transonic aeroelastic problems, including transonic buzz, reduction of transonic buffet onset, transonic buffeting response and frequency lock-in phenomenon in transonic buffet flow. After introducing the research methods in unsteady aerodynamics and aeroelastic problems, the dynamical characteristics as well as the physical mechanisms of these phenomena are discussed from the perspective of the fluid mode. In the framework of the ROM (reduced order model) -based model, the dominant fluid mode (or the eigenvalue) and its coupling process with the structural model can be clearly captured. The flow nonlinearity was believed to be the cause of the complexity of transonic aeroelasticity. In fact, this review indicates that the complexity lies in the decrease of the flow stability in the transonic regime. In this condition, the fluid mode becomes a principal part of the coupling process, which results in the instability of the fluid mode itself or the structural mode, and thus, it is the root cause of different transonic aeroelastic phenomena.
Conserved cosmological perturbations
Creators: name: Lyth, David H
name: Wands, David
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: A conserved cosmological perturbation is associated with each quantity whose local evolution is determined entirely by the local expansion of the Universe. It may be defined as the appropriately normalised perturbation of the quantity, defined using a slicing of spacetime such that the expansion between slices is spatially homogeneous. To first order, on super-horizon scales, the slicing with unperturbed intrinsic curvature has this property. A general construction is given for conserved quantities, yielding the curvature perturbation $ζ$ as well as more recently-considered conserved perturbations. The construction may be extended to higher orders in perturbation theory and even into the non-perturbative regime.
description: 21 pages, latex with revtex, no figures
Βιοηθικά και νομικά ζητήματα επαγγελματιών Υγείας περί του τέλους της ζωής στην Μονάδα Εντατικής Θεραπείας
Creators: name: Ζέρη, Κυριακή Δημητρίου
Publisher: name: Aristotle University of Thessaloniki
Year: 2021
Subjects: Εντατική θεραπεία
Θάνατος
Μονάδα Εντατικής Θεραπείας
Ηθικά-νομικά-βιοηθικά διλήμματα
Critical care
Death
Intensive Care Unit
Ethical-legal-bioethical dilemmas

description: Ο πληθυσμός της γης αυξάνεται και καθώς οι ιατρικές τεχνικές, τα φαρμακευτικά προϊόντα και οι συσκευές ωθούν τα όρια των ανθρώπινων φυσιολογικών ικανοτήτων, περισσότεροι άνθρωποι θα συνεχίσουν να ζουν περισσότερο. Ωστόσο, αυτή η παρατεταμένη ύπαρξη μπορεί να δημιουργήσει ηθικά και νομικά διλλήματα, ιδιαίτερα αναφορικά με το τέλος του κύκλου ζωής, και ιδιαίτερα στη Μονάδα Εντατικής Θεραπείας (ΜΕΘ). Αυτή η αρένα περιλαμβάνει όχι μόνο ασθενείς και οικογένειες, αλλά και φροντιστές υγείας. Περιλαμβάνει εύρος θεμάτων που εκτίνονται από την οικονομία έως τον υπαρξισμό και από τη χειρουργική επέμβαση μέχρι τον πνευματισμό. Απαιτεί εκπαίδευση, επικοινωνία, αποδοχή της διαφορετικότητας και απόλυτη συγκατάθεση στο αναπόφευκτο. Η παρούσα εργασία, παρουσιάζει μια ολοκληρωμένη επισκόπηση των ΜΕΘ και των δυνατοτήτων τους, των θεμάτων που προκύπτουν αναφορικά με τη διατήρηση ή όχι της ζωής και τα ηθικά, νομικά και βιοηθικά διλλήματα, σχετικά με το τέλος της ζωής στην ΜΕΘ.
description: The population of the earth is growing, and as medical techniques, pharmaceuticals, and devices push the boundaries of human physiological capabilities, more humans will go on to live longer. However, this prolonged existence may create ethical and legal dilemmas, particularly with regard to the end-of-life cycle, and especially in the Intensive Care Unit (ICU). This cycle involves not only patients and families, but also care givers. It involves topics from economics to existentialism, and surgery to spiritualism. It requires education, communication, acceptance of diversity, and an ultimate acquiescence to the inevitable. This paper presents a comprehensive overview of ICUs and their capabilities, the issues that arise regarding the preservation or not of life and the ethical, legal and bioethical dilemmas, regarding the end-of-life in ICU.
A Study on Mechanisms for Benefit-sharing of Biodiversity and Related Knowledge: With Reference to Case Studies on Geographical Indications and Trademarks
Creators: name: Oh, Yunseok
name: Oh, Yunseok
Publisher: name: Unknown
Year: 2004
Subjects: subject: Agricultural and Food Policy
subject: Biodiversity
subject: traditional knowledge
subject: Benefit-Sharing
subject: Geographical indications
subject: Trademarks

description: This study reviews the innovative use of some legal tools to support the efforts of the people of local and indigenous communities to conserve and use sustainably their biological diversity, biological resources, and related traditional knowledge. So, this study reviews concepts of intellectual property- in particular geographical indications and trademarks- as possible incentives for the marketing of products from biological resources produced through traditional and environmentally friendly methods. It includes case studies: Kava, Rooibos, Quinoa, Basmati rice and Neem. Through the case studies, this study will review two forms of intellectual property rights, which have received relatively little attention in discussions of sustainable use or benefit-sharing derived from bioresources and traditional knowledge. Conclusionally, geographical indications and trademarks could potentially serve as tools to help holders of traditional knowledge benefit more equitable for the commercial use of their knowledge.
Analysis of bleeding outcomes in patients with hypoproliferative thrombocytopenia in the A‐TREAT clinical trial
Creators: name: Gernsheimer, Terry B.
name: Triulzi, Darrell J.
name: Brown, Siobhan P.
name: El Kassar, Nahed
name: May, Susanne
name: Herren, Heather
name: Key, Nigel S.
name: Ginsburg, Amy Sarah
name: Ilich, Anton
name: Poston, Jacqueline N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2024

description: Background: Despite prophylactic platelet transfusions, hypoproliferative
thrombocytopenia is associated with bleeding; historical risk factors include
hematocrit (HCT) ≤25%, activated partial thromboplastin time ≥30 s, international normalized ratio ≥1.2, and platelets ≤5000/μL.
Methods: We performed a post hoc analysis of bleeding outcomes and risk
factors in participants with hematologic malignancy and hypoproliferative
thrombocytopenia enrolled in the American Trial to Evaluate Tranexamic Acid
Therapy in Thrombocytopenia (A-TREAT) and randomized to receive either
tranexamic acid (TXA) or placebo.
Results: World Health Organization (WHO) grade 2+ bleeding occurred in
46% of 330 participants, with no difference between the TXA (44%) and placebo (47%) groups (p = 0.66). Overall, the most common sites of bleeding
were oronasal (18%), skin (17%), gastrointestinal (11%), and genitourinary
(11%). Among participants of childbearing potential, 28% experienced vaginal bleeding. Platelets ≤5000/μL and HCT < 21% (after adjusting for
severe thrombocytopenia) were independently associated with increased
bleeding risk (HR 3.78, 95% CI 2.16–6.61; HR 2.67, 95% CI 1.35–5.27, respectively). Allogeneic stem cell transplant was associated with nonsignificant
increased risk of bleeding versus chemotherapy alone (HR 1.34, 95% CI
0.94–1.91).
Discussion: The overall rate of WHO grade 2+ bleeding was similar to previous reports, albeit with lower rates of gastrointestinal bleeding. Vaginal
bleeding was common in participants of childbearing potential. Platelets
≤5000/μL remained a risk factor for bleeding. Regardless of platelet count,
bleeding risk increased with HCT < 21%, suggesting a red blood cell transfusion threshold above 21% should be considered to mitigate bleeding.
More investigation is needed on strategies to reduce bleeding in this
population.
Modeling, Simulation and Optimization of Nuclear Hybrid Energy Systems Using OpenModelica and RAVEN
Creators: name: Hills, Stephen Michael
Publisher: name: Utah State University
Year: 2021

description: Nuclear hybrid energy systems (NHES) are a viable option to combine renewable energy sources, such as wind, with a less fluctuating energy source. Given recent development and their inherent safer and modular design, small modular reactors (SMRs), which are smaller versions of a nuclear reactor, can play an instrumental role in complementing renewables and supporting carbon-free power sectors in the coming decades. With increasing population and demand for clean water, Freeze desalination (FD), which uses freezing to separate water from salt, is a possible way to produce clean water while converting excess power from a SMR into stored thermal energy in an ice water tank. The stored thermal energy can then be used during peak hours to boost the power generation by improving the efficiency of the Rankine cycle of the SMR. Reverse osmosis (RO), which uses membrane and high water pressure to separate water from salt, is another possible way to use excess power generation to efficiently produce clean water.
This paper uses OpenModelica, an open source software package, to model two types of NHES to produce clean energy and water, both powered by SMRs and wind turbines. The first system uses FD and the second system uses RO to generate clean water. RAVEN and TEAL, an economic analysis plugin for RAVEN, are used to optimize both systems for two case locations, Salt Lake City, Utah and San Diego, California.
The results from the two cases show that for water prices less than $1.50 per m3, the FD system would be more economic. Since the RO system produced much more clean water, as water prices rise above $1.50 per m3, it becomes more advantageous to use the RO system, assuming that there are no negative impacts to increased water storage. The FD system is able to use the stored thermal energy to boost the power production by 12% during peak hours by increasing the efficiency of the Rankine cycle by 2%. This allows less capital investment on SMR/wind turbines, as well as less penalty due to mismatch of energy production and demand.
Economics of Conversion to Environmentally Friendly Practices of Rice Production
Creators: name: Kim, Changgil
name: Kim, Taeyoung
name: Kim, Changgil
name: Kim, Taeyoung
Publisher: name: Unknown
Year: 2004
Subjects: subject: Farm Management
subject: Environmentally friendly rice farming
subject: organic production
subject: conventional farming
subject: whole farm planning
subject: physical productivity
subject: economic performance
subject: farm-gate price premium

description: Environmentally friendly rice farming practices in Korea divide into three groups such as organic production with no synthetic pesticides of fertilizers applied, no-pesticide production not using pesticides, and low-pesticide production using low quantities of synthetic pesticides and with an appropriate nutrient manage- ment. This paper discusses some methodological aspects important for the comparative analysis of the economic performance of rice farming practices, and gives an overview of the financial performance of environmentally friendly farming practices at farm level using the survey data. The revenues of environmentally friendly and conventional rice farms are compared, and then main factors influencing profitability, especially yields, price premium and production costs are discussed. The result shows that conversion payment for promoting environmentally friendly rice farming practices need to compensate for cost increment and/or income reduction during the three to five years within switching periods depending on the realization of farm-gate premium prices.