cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Identification of a core member of the SWI/SNF complex, BAF155/SMARCC1, as a human tumor suppressor gene
Creators: name: DelBove, Jessica
name: Knudsen, Erik S.
name: Archer, Trevor K.
name: Wang, Weidong
name: Strobeck, Matthew
name: Weissman, Bernard E.
name: Rosson, Gary
name: Chen, Jianguang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Recent studies have established that two core members of the SWI/SNF chromatin remodeling complex, BRG1 and SNF5/INI1, possess tumor-suppressor activity in human and mouse cancers. While the third core member, BAF155, has been implicated by several studies as having a potential role in tumor development, direct evidence for its tumor suppressor activity has remained lacking. Therefore, we screened for BAF155 deficiency in a large number of human tumor cell lines. We identified two cell lines, the SNUC2B colon carcinoma and the SKOV3 ovarian carcinoma, displaying a complete loss of protein expression while maintaining normal levels of mRNA expression. The SKOV3 cell line possesses a heterozygous 4 bp deletion that results in an 855AA truncated protein, while the cause of the loss of BAF155 expression in the SNUC2B cell line appears due to a post-transcriptional error. However, the lack of detectable BAF155 expression did not affect sensitivity to RB-mediated cell cycle arrest. Re-expression of full length but not a truncated form of BAF155 in the two cancer cell lines leads to reduced colony forming ability characterized by replicative senescence but not apoptosis. Collectively, these data suggest that loss of BAF155 expression represents another mechanism for inactivation of SWI/SNF complex activity in the development in human cancer. Our results further indicate that the c-terminus proline-glutamine rich domain plays a critical role in the tumor suppressor activity of this protein.
Nucleosomes in the neighborhood: New roles for chromatin modifications in replication origin control
Creators: name: Dorn, Elizabeth Suzanne
name: Cook, Jeanette Gowen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The importance of local chromatin structure in regulating replication initiation has become increasingly apparent. Most recently, histone methylation and nucleosome positioning have been added to the list of modifications demonstrated to regulate origins. In particular, the methylation states of H3K4, H3K36 and H4K20 have been associated with establishing active, repressed or poised origins depending on the timing and extent of methylation. The stability and precise positioning of nucleosomes has also been demonstrated to affect replication efficiency. Although it is not yet clear how these modifications alter the behavior of specific replication factors, ample evidence establishes their role in maintaining coordinated replication. This review will summarize recent advances in understanding these aspects of chromatin structure in DNA replication origin control.
Mono-Alkyl-Substituted Phosphinoboranes (HRP–BH2–NMe3) as Precursors for Poly(alkylphosphinoborane)s: Improved Synthesis and Comparative Study
Creators: name: Lehnfeld, Felix
name: Oswald, Tim
name: Beckhaus, Rüdiger
name: Scheer, Manfred
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: 13/15 compounds; boron; phosphorus; polymerization
subject: 540 Chemie

description: A new synthetic pathway to various mono-alkyl-substituted phosphinoboranes HRP–BH2–NMe3 has been developed. The new synthetic route starting from alkyl halides and NaPH2 followed by metalation and salt metathesis is performed in a one-pot procedure and leads to higher yields and purity of the resulting phosphinoboranes, as compared to previously reported routes. Additionally, the scope of accessible compounds could be expanded from short-chained linear alkyl substituents to longer-chained linear alkyl substituents as well as secondary or functionalized alkyl substituents. The reported examples include primary alkyl-substituted phosphinoboranes RHP-BH2-NMe3 (R = n-butyl, n-pentyl, n-hexyl; 1a–c), the secondary alkyl-substituted derivatives iPrPH-BH2-NMe3 (2), and the functionalized alkyl-substituted 4-bromo-butyl-phosphinoborane (BrC4H8)PH-BH2-NMe3 (3). Compounds 1a, 1c, and 2 were additionally used for preliminary polymerization reactions via a thermal and a transition metal-catalyzed pathway, revealing the formation of high-molecular-weight polymers under certain conditions. Detailed investigations on the influence of temperature, concentration, substituents and reaction time on the respective polymerization reactions were performed.
Reactivation of MASPIN in non-small cell lung carcinoma (NSCLC) cells by artificial transcription factors (ATFs)
Creators: name: Beltran, Adriana S.
name: Blancafort, Pilar
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Tumor suppressor genes have antiproliferative and antimetastatic functions and thus, they negatively affect tumor progression. Reactivating specific tumor suppressor genes would offer an important therapeutic strategy to block tumor progression. Mammary serine protease inhibitor (MASPIN) is a tumor suppressor gene that is not mutated or rearranged in tumor cells, but is silenced during metastatic progression by transcriptional and epigenetic mechanisms. In this work, we have investigated the ability of artificial transcription factors (ATFs) to reactivate MASPIN expression and to reduce tumor growth and metastatic dissemination in non-small cell lung carcinoma (NSCLC) cell lines carrying a hypermethylated MASPIN promoter. We found that the ATFs linked to transactivator domains were able to demethylate the MASPIN promoter. Consistently, we observed that co-treatment of ATF-transduced cells with methyltransferase inhibitors enhanced MASPIN expression as well as induction of tumor cell apoptosis. In addition to tumor suppressive functions, restoration of endogenous MASPIN expression was accompanied by inhibition of metastatic dissemination in nude mice. ATF-mediated reactivation of MASPIN lead to changes in cell motility and to induction of E-CADHERIN. These data suggest that ATFs are able to reprogram aggressive lung tumor cells towards a more epithelial, differentiated phenotype and represent novel therapeutic agents for metastatic lung cancers.
The Neutrino Opacity of Neutron Star Inner Crust
Creators: name: Alcain, P. N.
name: Dorso, C. O.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The study of neutron rich matter, present in neutron star, proto-neutron stars and core-collapse supernovae, can lead to further understanding of the behavior of nuclear matter in highly asymmetric nuclei. Heterogeneous structures are expected to exist in these systems, often referred to as nuclear pasta. We have carried out a systematic study of neutrino opacity for different thermodynamic conditions in order to assess the impact that the structure has on it. We studied the dynamics of the neutrino opacity of the heterogeneous matter at different thermodynamic conditions with semiclassical molecular dynamics model already used to study nuclear multifragmentation. For different densities, proton fractions and temperature, we calculate the very long range opacity and the cluster distribution. The neutrino opacity is of crucial importance for the evolution of the core-collapse supernovae and the neutrino scattering.
Magic angle conditions for twisted 3D topological insulators
Creators: name: Dunbrack, Aaron
name: Cano, Jennifer
Publisher: name: arXiv
Year: 2021
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We derive a general low-energy theory for twisted moiré heterostructures comprised of Dirac materials. We apply our theory to heterostructures on the surface of a three dimensional topological insulator (3D TI). First, we consider the interface between two 3D TIs arranged with a relative twist angle. We prove that if the two TIs are identical, then a necessary condition for a magic angle where the Dirac cone velocity vanishes is to have an interlayer spin-flipping hopping term. Without this term, the Dirac cone velocities can still be significantly renormalized, decreasing to less than half of their original values, but they will not vanish. Second, we consider graphene on the surface of a TI arranged with a small twist angle. Again, a magic angle is only achievable with a spin-flipping hopping term. Without this term, the Dirac cone is renormalized, but not significantly. In both cases, our perturbative results are verified by computing the band structure of the continuum model. The enhanced density of states that results from decreasing the surface Dirac cone velocity provides a tunable route to realizing interacting topological phases.
Performance Analysis of a Gas Cyclone with a Dustbin Inverted Hybrid Solid Cone
Creators: name: Dehdarinejad, E.
name: Parvaz, F.
name: Hosseini, S. H.
name: Ahmadi, G.
name: Elsayed, K.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: This study uses the CFD technique to investigate the influence of a twisted inverted hybrid solid cone (TIHSC) placed at the gas cyclone dustbin on the separator performance. This new design improves the stability and reduces the length of the vortex finder, resulting in a stronger swirl in the cyclone with a higher tangential velocity. The study showed that an increase in the height of the TIHSC increases the maximum tangential velocity up to 2.9 times the inlet velocity. Overall, using TIHSC leads to a significant increase in particle separation efficiency compared to the conventional cyclone. In addition, with an increase in the height of TIHSC, the pressure drop significantly decreases while the separation efficiency increases. For the optimized model, the particle cut size improves from 0.97 to 0.85 µm at 50% separation and from 6.2 to 4.7 µm at 100% separation, while the pressure drop is reduced by 12.7%.
Exhaustivity in the pen33-Cleft in Thai: A formal semantics account
Creators: name: Upsorn Tawilapakul
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2017
Subjects: clefts
exhaustivity
Thai
parthood relation
pen33

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 17, 2, 102-126
The influence of one-carbon metabolism on gene promoter methylation in a population-based breast cancer study
Creators: name: Garbowski, Gail
name: Jefferson, Elizabeth
name: Santella, Regina M.
name: Neugut, Alfred I.
name: Gammon, Marilie D.
name: Teitelbaum, Susan L.
name: Terry, Mary Beth
name: Cho, Yoon Hee
name: Chen, Jia
name: Wetmur, James G.
name: Hibshoosh, Hanina
name: Bradshaw, Patrick T.
name: Xu, Xinran
name: Zhang, Yujing
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Abnormal methylation in gene promoters is a hallmark of the cancer genome; however, factors that may influence promoter methylation have not been well elucidated. As the one-carbon metabolism pathway provides the universal methyl donor for methylation reactions, perturbation of this pathway might influence DNA methylation and, ultimately, affect gene functions. Utilizing approximately 800 breast cancer tumor tissues from a large population-based study, we investigated the relationships between dietary and genetic factors involved in the one-carbon metabolism pathway and promoter methylation of a panel of 13 breast cancer-related genes. We found that CCND2, HIN1 and CHD1 were the most “dietary sensitive” genes, as methylation of their promoters was associated with intakes of at least two out of the eight dietary methyl factors examined. On the other hand, some micronutrients (i.e., B2 and B6) were more “epigenetically active” as their intake levels correlated with promoter methylation status in 3 out of the 13 breast cancer genes evaluated. Both positive (hypermethylation) and inverse (hypomethylation) associations with high micronutrient intake were observed. Unlike what we saw for dietary factors, we did not observe any clear patterns between one-carbon genetic polymorphisms and the promoter methylation status of the genes examined. Our results provide preliminary evidence that one-carbon metabolism may have the capacity to influence the breast cancer epigenome. Given that epigenetic alterations are thought to occur early in cancer development and are potentially reversible, dietary modifications may offer promising venues for cancer intervention and prevention.
Arrenurus (Arrenurus) torae Lundblad 1969
Creators: name: Pešić, Vladimir
name: Chatterjee, Tapas
name: Bordoloi, Sabitry
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Arrenuridae
Arrenurus
Arrenurus torae

description: Arrenurus (Arrenurus) torae Lundblad, 1969
Remarks: Lundblad (1969) did not feel certain about the locality of his specimens, they were either from Calcutta (India) or Colombo (Sri Lanka).
Distribution: India or Sri Lanka.
description: Published as part of Pešić, Vladimir, Chatterjee, Tapas & Bordoloi, Sabitry, 2010, A checklist of the water mites (Acari: Hydrachnidia) of India, with new records and description of one new species, pp. 1-54 in Zootaxa 2617 (1) on page 49, DOI: 10.11646/zootaxa.2617.1.1, http://zenodo.org/record/197964
General Covariance from the Viewpoint of Stacks
Creators: name: Dul, Filip
Publisher: name: arXiv
Year: 2021
Subjects: subject: Mathematical Physics (math-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Differential Geometry (math.DG)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: General covariance is a crucial notion in the study of field theories in curved spacetime. A field theory defined with respect to a semi-Riemannian metric is generally covariant if two metrics which are related by a diffeomorphism produce equivalent physics. From a purely mathematical perspective, this suggest that we try to understand the quotient stack of metrics modulo diffeomorphism. We'll use the language of groupoids to do this concretely. Then we'll inspect the tangent complex of this stack at a fixed metric, which when shifted up by one defines a differential graded Lie algebra. By considering the action of this Lie algebra on the observables for the Batalin-Vilkovisky free scalar field theory, we recover a novel expression of the stress-energy tensor for that example. We'll describe how this construction nicely encapsulates but also broadens the usual presentation in the physics literature and discuss applications of the formalism.
OHEJP COVRIN D0.3.4 Report on Final meeting Dec 2022.
Creators: name: Horton, Daniel
name: Marston, Denise
Publisher: name: Zenodo
Year: 2023
Subjects: OHEJP
COVRIN
SARS-CoV-2
One Health
final meeting report

description: Report on the final meeting for COVRIN. To note the slide deck can be accessed here: https://zenodo.org/record/7781504
Subsystem entropies of shifts of finite type and sofic shifts on countable amenable groups
Creators: name: Bland, Robert
name: McGoff, Kevin
name: Pavlov, Ronnie
Publisher: name: arXiv
Year: 2022
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 37B10 (Primary) 37B40, 37B51 (Secondary)

description: In this work we study the entropies of subsystems of shifts of finite type (SFTs) and sofic shifts on countable amenable groups. We prove that for any countable amenable group $G$, if $X$ is a $G$-SFT with positive topological entropy $h(X) > 0$, then the entropies of the SFT subsystems of $X$ are dense in the interval $[0, h(X)]$. In fact, we prove a "relative" version of the same result: if $X$ is a $G$-SFT and $Y \subset X$ is a subshift such that $h(Y) < h(X)$, then the entropies of the SFTs $Z$ for which $Y \subset Z \subset X$ are dense in $[h(Y), h(X)]$. We also establish analogous results for sofic $G$-shifts.
description: 32 pages, 4 figures
title: Inter-American Indemnity: Internal Security and the Mutual Security Program for Latin America (1951-1961)
Creators: name: Baker, Robert George
Publisher: name: Old Dominion University Libraries
Year: 1991

description: This thesis examines the purpose of U.S. military aid in the American Republics from 1951 through 1961 and proves that concern for internal security became dominant during that period. At first military aid supported hemispheric defense against communist aggression, which Washington orchestrated through mutual defense agreements, but by 1953 maintenance of internal security emerged as the major aim of aid to several Central American nations. In 1956 the National Security Council determined that internal security was a vital goal of the military aid program for Latin America. The ascendance of internal security concerns is described and analyzed in three parts: first as an appendage to the anticommunist Mutual Security Program, then as an expanding program element, and finally as the dominant objective for assisting the Latin American military. Recently released U.S. government document collections are used extensively in this study, which contributes to revision of the period.
Development of drone-based filter sampling system for carbonaceous aerosol analysis using thermal–optical transmittance method
Creators: name: Park, Jaebeom
name: Kwak, Dong-Bin
name: Baek, Minwoo
name: Lee, Songhui
name: Kim, Woo Young
name: Kim, Ki Ae
name: Lee, Ji Yi
name: Ahn, Kang-Ho
name: Lee, Handol
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Application of a drone-based, high-volume (38 L min−1) sampling system developed for time-resolved monitoring of elemental and organic carbon (EC and OC) is demonstrated in this study. Filter samples collected by the samplers were analyzed by a laboratory-based, thermal-optical transmittance (TOT) method of the National Institute for Occupational Safety and Health using a Sunset Laboratory OC-EC analyzer. The EC, OC, and total carbon (TC) results for filter samples collected by the high-volume (38 L min−1) sampler are compared to those obtained by a low-volume (4 L min−1) sampler at ground level. Prior to the use of the developed high-volume sampler at 150 m, three 30-min air samples, taken from 11:00 to 15:00, and three 1-h samples, taken between 15:00 and 22:00, were collected at ground level by the drone-based system. For reference, the low-volume filter sample was collected over the 12-h period on the same day. In addition, particulate matter and black carbon concentrations were obtained as supportive data. In the ground-level test, the average EC, OC, and TC concentrations determined with the high-volume (drone) samples agree well with those determined with the 12-h, integrated, low-volume sample. Further field samplings on the ground and at 150-m were conducted over 2 days to assess the developed drone-based sampling system for measurement of carbonaceous aerosols. The EC, OC, and TC concentrations at a 150-m altitude were successfully examined via drone-based, high-volume sampling and TOT analysis. Copyright © 2023 American Association for Aerosol Research
Detection of promoter methylation of tumor suppressor genes in serum DNA of breast cancer cases and benign breast disease controls
Creators: name: Ziegler, Regina G.
name: Sturgeon, Susan R.
name: Balasubramanian, Raji
name: Muss, Hyman B.
name: Arcaro, Kathleen F.
name: Schairer, Catherine
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Tumors are capable of shedding DNA into the blood stream. This shed DNA may be recovered from serum or plasma. The objective of this study was to evaluate whether pyrosequencing promoter DNA in a panel of 12 breast cancer-related genes (APC, BRCA1, CCND2, CDH1, ESR1, GSTP1, HIN1, P16, RARβ, RASSF1, SFRP1 and TWIST) to measure the degree of methylation would lead to a useful serum-based marker of breast cancer. Serum was obtained from women who were about to undergo a breast biopsy or mastectomy at three hospitals from 1977 to 1987 in Grand Rapids, MI USA. We compared the methylation status of 12 genes in serum DNA obtained from three groups of postmenopausal women (mean age at blood collection: 63.0 y; SD 9.9; range 35–91): breast cancer cases with lymph node-positive disease (n = 241); breast cancer cases with lymph node-negative disease (n = 63); and benign breast disease control subjects (n = 234). Overall, median levels of promoter methylation were low, typically below 5%, for all genes in all study groups. For all genes, median levels of methylation were higher (by 3.3 to 47.6%) in lymph node-positive breast cancer cases than in the controls. Comparing mean methylation level between lymph-node positive cases and controls, the most statistically significant findings, after adjustment of the false-positive rate (q-value), were for TWIST (p = 0.04), SFRP1 (p = 0.16), ESR1 (p = 0.17), P16 (p = 0.19) and APC (p = 0.19). For two of these four genes (TWIST, P16), the median methylation level was also highest in lymph-node positive cases, intermediate in lymph node-negative cases and lowest in the controls. The percent of study subjects with mean methylation scores ≥ 5% was higher among lymph node-positive cases than controls for ten genes, and significantly higher for HIN1 and TWIST (22.0 vs. 12.2%, p = 0.04 and 37.9 vs. 24.5%, p = 0.004, respectively). Despite relatively consistent variation in methylation patterns among groups, these modest differences did not provide sufficient ability to distinguish between cases and controls in a clinical setting.
Altitude Plant Density Interaction on Andean Maize: Contributions to Decision Making
Creators: name: Salve, Diego
name: Maydup, Maria Lujan
name: Tambussi, Eduardo
name: Salazar, German
name: Antonietta, Mariana
Publisher: name: ITPGRFA
Year: 2023
Subjects: ARG
Yields
PR-154
ITPGRFA-BSF
Maize
Adaptation
Farmers
Conservation

description: This poster is the result of a research done  by Diego Salve et al., associated with the project  PR-154-Argentina "Conservación y uso sostenible de los recursos fitogenéticos locales para la alimentación y la agricultura (RFAA) para contribuir a la seguridad alimentaria de los pequeños agricultores de Argentina"project funded in the 4th cycle of the Benefit Sharing Fund (BSF) of the International Treaty on Plant Genetic Resources for Food and Agriculture (ITPGRFA) of the Food and Agriculture Organization (FAO) . The research explores whether maize crop yields are limited by a progressive decrease in temperature with increasing altitude in the E-W direction of the Northwest of Argentina. To conduct this research, partners sampled plant density and yields from 8 registered farmer's fields. They found that increased plant density can improve light interception, in so doing, improving yield in high altitude environments. However, further work will be required to explore these conclusions.
Epigenetic reprogramming of cancer cells via targeted DNA methylation
Creators: name: Stolzenburg, Sabine
name: Rots, Marianne G.
name: Beltran, Adriana S.
name: Strahl, Brian D.
name: Blancafort, Pilar
name: Yuan, Xinni
name: Rivenbark, Ashley G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: An obstacle in the treatment of human diseases such as cancer is the inability to selectively and effectively target historically undruggable targets such as transcription factors. Here, we employ a novel technology using artificial transcription factors (ATFs) to epigenetically target gene expression in cancer cells. We show that site-specific DNA methylation and long-term stable repression of the tumor suppressor Maspin and the oncogene SOX2 can be achieved in breast cancer cells via zinc-finger ATFs targeting DNA methyltransferase 3a (DNMT3a) to the promoters of these genes. Using this approach, we show Maspin and SOX2 downregulation is more significant as compared with transient knockdown, which is also accompanied by stable phenotypic reprogramming of the cancer cell. These findings indicate that multimodular Zinc Finger Proteins linked to epigenetic editing domains can be used as novel cell resources to selectively and heritably alter gene expression patterns to stably reprogram cell fate.
Probing QCD critical point and induced gravitational wave by black hole physics
Creators: name: Cai, Rong-Gen
name: He, Song
name: Li, Li
name: Wang, Yuan-Xu
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Locating the critical endpoint of QCD and the region of a first-order phase transition at finite baryon chemical potential is an active research area for QCD matter. We provide a gravitational dual description of QCD matter at finite baryon chemical potential and finite temperature using the non-perturbative approach from gauge/gravity duality. After fixing all model parameters using state-of-the-art lattice QCD data at zero chemical potential, the predicted equations of state and QCD trace anomaly relation are in quantitative agreement with the latest lattice results. We then give the exact location of the critical endpoint as well as the first-order transition line, which is within the coverage of many upcoming experimental measurements. Moreover, using the data from our model at finite baryon chemical potential, we calculate the spectrum of the stochastic gravitational wave background associated with the first-order QCD transition in the early universe, which could be observable via pulsar timing in the future.
description: 5 + 10 pages, 13 figures
Mixed Hodge structure on complements of complex coordinate subspace arrangements
Creators: name: Eliyashev, Yury V.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Algebraic Geometry (math.AG)
subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics

description: We compute the mixed Hodge structure on the cohomology ring of complements of complex coordinate subspace arrangements. The mixed Hodge structure can be described in terms of the special bigrading on the cohomology ring of complements of complex coordinate subspace arrangements. Originally this bigrading was introduced in the setting of toric topology by V.M. Buchstaber and T.E. Panov.
description: arXiv admin note: text overlap with arXiv:1305.2549 Final version, minor corrections, some reference added
of Factors associated with No-Shows and rescheduling MRI appointments
Creators: name: AlRowaili, Majeed
name: Ahmed, Anwar
name: Areabi, Hasan
Publisher: name: figshare
Year: 2019
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: of Factors associated with No-Shows and rescheduling MRI appointments
Применение формалина для обработки навоза подстилки дойных коров
Creators: name: Frolov, Dmitry I.
name: Potapov, M.A.
Publisher: name: figshare
Year: 2022
Subjects: subject: 70201 Animal Breeding
subject: FOS: Animal and dairy science

description: Comparative studies have been carried out on the use of formalin at concentrations of 2% and 4% for the treatment of fresh and aged manure from litter from dairy cows for the purpose of disinfection. To do this, we monitored the change in the number of microorganisms contained in the fertilizer, as well as pathogenic test strains of Proteus vulgaris, Pseudomonas aeruginosa and Staphylococcus epidermidis, which are resistant to gentamicin and tetracycline antibiotics. Test bacteria were introduced in the amount of 105 CFU/g of their total content. It has been established that formalin treatment at two test concentrations of 2% and 4% ensures the inactivation of pathogenic test microorganisms and Clostridium perfringens contained in the tested samples of fresh and rotted manure, even after a day. Inactivation of Escherichia coli found in both manure samples was achieved after 48 hours when treated with 2% formalin, and only after 24 hours at a concentration of 4%. In fresh manure, after treatment with 4% formalin, all microorganisms died after 96 hours, and in aged manure - even after 72 hours. The introduction of 2% formalin ensures the destruction of all microorganisms in fresh and aged cattle manure within 120 hours. The use of formalin at a final concentration of 4% does not give much better results than doubling the lowest concentration of 2%, which is recommended for use..
Association between hypermethylation of DNA repetitive elements in white blood cell DNA and early-onset colorectal cancer
Creators: name: Walters, Rhiannon J.
name: Win, Aung Ko
name: Giles, Graham G.
name: Young, Joanne P.
name: Parry, Susan
name: Baron, John A.
name: Williamson, Elizabeth J.
name: Walsh, Michael D.
name: Clendenning, Mark
name: Ahnen, Dennis J.
name: Hopper, John L.
name: English, Dallas R.
name: Rosty, Christophe
name: Buchanan, Daniel D.
name: Jenkins, Mark A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Changes in the methylation levels of DNA from white blood cells (WBCs) are putatively associated with an elevated risk for several cancers. The aim of this study was to investigate the association between colorectal cancer (CRC) and the methylation status of three DNA repetitive elements in DNA from peripheral blood. WBC DNA from 539 CRC cases diagnosed before 60 years of age and 242 sex and age frequency-matched healthy controls from the Australasian Colorectal Cancer Family Registry were assessed for methylation across DNA repetitive elements Alu, LINE-1 and Sat2 using MethyLight. The percentage of methylated reference (PMR) of cases and controls was calculated for each marker. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multivariable logistic regression adjusted for potential confounders. CRC cases demonstrated a significantly higher median PMR for LINE-1 (p < 0.001), Sat2 (p < 0.001) and Alu repeats (p = 0.02) when compared with controls. For each of the DNA repetitive elements, individuals with PMR values in the highest quartile were significantly more likely to have CRC compared with those in the lowest quartile (LINE-1 OR = 2.34, 95%CI = 1.48–3.70; p < 0.001, Alu OR = 1.83, 95%CI = 1.17–2.86; p = 0.01, Sat2 OR = 1.72, 95%CI = 1.10–2.71; p = 0.02). When comparing the OR for the PMR of each marker across subgroups of CRC, only the Alu marker showed a significant difference in the 5-fluoruracil treated and nodal involvement subgroups (both p = 0.002). This association between increasing methylation levels of three DNA repetitive elements in WBC DNA and early-onset CRC is novel and may represent a potential epigenetic biomarker for early CRC detection.
Breaking through an epigenetic wall: Re-activation ofOct4by KRAB-containing designer zinc finger transcription factors
Creators: name: Juárez-Moreno, Karla
name: Stolzenburg, Sabine
name: Blancafort, Pilar
name: Erices, Rafaela
name: Qian, Haili
name: Owen, Gareth I.
name: Cuello-Fredes, Mauricio
name: Beltran, Adriana S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The gene Oct4 encodes a transcription factor critical for the maintenance of pluripotency and self-renewal in embryonic stem cells. In addition, improper re-activation of Oct4 contributes to oncogenic processes. Herein, we describe a novel designer zinc finger protein (ZFP) capable of upregulating the endogenous Oct4 promoter in a panel of breast and ovarian cell lines carrying a silenced gene. In some ovarian tumor lines, the ZFP triggered a strong reactivation of Oct4, with levels of expression comparable with exogenous Oct4 cDNA delivery. Surprisingly, the reactivation of Oct4 required a KRAB domain for effective upregulation of the endogenous gene. While KRAB-containing ZFPs are traditionally described as transcriptional repressors, our results suggest that these proteins could, in certain genomic contexts, function as potent activators and, thus, outline an emerging novel function of KRAB-ZFPs. In addition, we document a novel ZFP that could be used for the epigenetic reprograming of cancer cells.
ตำแหน่งการปกครองและระบบไพก์ในอาณาจักรอาหม ค.ศ. 1228 - 1826
Creators: name: ขนบพร วงศ์กาฬสินธุ์
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2017
Subjects: อาหม
ไท
การปกครองอาหม
ไพก์
ไพร่

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 17, 2, 127-159
Purification of SLC9B2 from Expi293FTM Cells
Creators: name: David B. Sauer
name: Huanyu Li
name: Sagar Raturi
name: Andreea Scacioc
name: Tina Bohstedt
name: Abilasha Balakrishnan
Publisher: name: Zenodo
Year: 2022
Subjects: Protocol

description: This protocol is used to purify the SLC transporter expressed in Expi293FTM Cells using detergent solubilization followed by a series of different chromatographic methods. Depending on the nature of the expression construct and experimental requirements, the GFP tag can be removed using a proteolytic reaction.
Strong error analysis of Euler methods for overdamped generalized Langevin equations with fractional noise: Nonlinear case
Creators: name: Dai, Xinjie
name: Hong, Jialin
name: Sheng, Derui
name: Zhou, Tau
Publisher: name: arXiv
Year: 2022
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 65C20, 65C30, 65C05, 60H07

description: This paper considers the strong error analysis of the Euler and fast Euler methods for nonlinear overdamped generalized Langevin equations driven by the fractional noise. The main difficulty lies in handling the interaction between the fractional Brownian motion and the singular kernel, which is overcome by means of the Malliavin calculus and fine estimates of several multiple singular integrals. Consequently, these two methods are proved to be strongly convergent with order nearly $\min\{2(H+α-1), α\}$, where $H \in (1/2,1)$ and $α\in(1-H,1)$ respectively characterize the singularity levels of fractional noises and singular kernels in the underlying equation. This result improves the existing convergence order $H+α-1$ of Euler methods for the nonlinear case, and gives a positive answer to the open problem raised in [4]. As an application of the theoretical findings, we further investigate the complexity of the multilevel Monte Carlo simulation based on the fast Euler method, which turns out to behave better performance than the standard Monte Carlo simulation when computing the expectation of functionals of the considered equation.
of Genomic prediction with epistasis models: on the marker-coding-dependent performance of the extended GBLUP and properties of the categorical epistasis model (CE)
Creators: name: Martini, Johannes
name: Gao, Ning
name: Diercles Cardoso
name: Wimmer, Valentin
name: Erbe, Malena
name: Cantet, Rodolfo
name: Simianer, Henner
Publisher: name: figshare
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: of Genomic prediction with epistasis models: on the marker-coding-dependent performance of the extended GBLUP and properties of the categorical epistasis model (CE)
DNA methylation and nucleosome occupancy regulate the cancer germline antigen gene MAGEA11
Creators: name: Odunsi, Kunle
name: Karpf, Adam R
name: Zhang, Wa
name: Sharma, Ashok
name: Cedeno, Carlos D
name: James, Smitha R
name: Wilson, Elizabeth M
name: Mohler, James L
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: MAGEA11 is a cancer germline (CG) antigen and androgen receptor co-activator. Its expression in cancers other than prostate, and its mechanism of activation, has not been reported. In silico analyses reveal that MAGEA11 is frequently expressed in human cancers, is increased during tumor progression, and correlates with poor prognosis and survival. In prostate and epithelial ovarian cancers (EOC), MAGEA11 expression was associated with promoter and global DNA hypomethylation, and with activation of other CG genes. Pharmacological or genetic inhibition of DNA methyltransferases (DNMTs) and/or histone deacetylases (HDACs) activated MAGEA11 in a cell line specific manner. MAGEA11 promoter activity was directly repressed by DNA methylation, and partially depended on Sp1, as pharmacological or genetic targeting of Sp1 reduced MAGEA11 promoter activity and endogenous gene expression. Importantly, DNA methylation regulated nucleosome occupancy specifically at the -1 positioned nucleosome of MAGEA11. Methylation of a single Ets site near the transcriptional start site (TSS) correlated with -1 nucleosome occupancy and, by itself, strongly repressed MAGEA11 promoter activity. Thus, DNA methylation regulates nucleosome occupancy at MAGEA11, and this appears to function cooperatively with sequence-specific transcription factors to regulate gene expression. MAGEA11 regulation is highly instructive for understanding mechanisms regulating CG antigen genes in human cancer.
การพรรณนาภาษาปู้ยังในสาธารณรัฐประชาชนจีน
Creators: name: เมชฌ สอดส่องกฤษ
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2017
Subjects: ปู้ยัง
เกอ-ยัง
ภาษาตระกูลไท
ภาษากะได

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 17, 2, 160-202
Cadmium exposure and the epigenome: Exposure-associated patterns of DNA methylation in leukocytes from mother-baby pairs
Creators: name: Wright, Fred
name: Laine, Jessica
name: Lynn Miranda, Marie
name: Swamy, Geeta
name: Ashley-Koch, Alison
name: Rojas, Daniel
name: Sanders, Alison
name: Smeester, Lisa
name: Fry, Rebecca
name: Zhou, Yi-Hui
name: DeBussycher, Tristan
name: Wu, Michael
name: Rager, Julia
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Cadmium (Cd) is prevalent in the environment yet understudied as a developmental toxicant. Cd partially crosses the placental barrier from mother to fetus and is linked to detrimental effects in newborns. Here we examine the relationship between levels of Cd during pregnancy and 5-methylcytosine (5mC) levels in leukocyte DNA collected from 17 mother-newborn pairs. The methylation of cytosines is an epigenetic mechanism known to impact transcriptional signaling and influence health endpoints. A methylated cytosine-guanine (CpG) island recovery assay was used to assess over 4.6 million sites spanning 16,421 CpG islands. Exposure to Cd was classified for each mother-newborn pair according to maternal blood levels and compared with levels of cotinine. Subsets of genes were identified that showed altered DNA methylation levels in their promoter regions in fetal DNA associated with levels of Cd (n = 61), cotinine (n = 366), or both (n = 30). Likewise, in maternal DNA, differentially methylated genes were identified that were associated with Cd (n = 92) or cotinine (n = 134) levels. While the gene sets were largely distinct between maternal and fetal DNA, functional similarities at the biological pathway level were identified including an enrichment of genes that encode for proteins that control transcriptional regulation and apoptosis. Furthermore, conserved DNA motifs with sequence similarity to specific transcription factor binding sites were identified within the CpG islands of the gene sets. This study provides evidence for distinct patterns of DNA methylation or “footprints” in fetal and maternal DNA associated with exposure to Cd.
Matthew, T. Prior (2016). Emotion and Discourse in L2 Narrative Research UK: Multilingual Matters. 260 pp. (paperback). ISBN-13: 978-1-78309-442-4.
Creators: name: Hai, Lin
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2017
Subjects: -

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 17, 2, 203-205
Broad frequency and amplitude control of vibration in freestanding graphene via scanning tunneling microscopy with calculated dynamic pseudo-magnetic fields
Creators: name: Xu, P.
name: Schoelz, J. K.
name: Barber, S. D.
name: Ackerman, M. L.
name: Thibado, P. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: A technique to locally generate mechanical vibrations in freestanding graphene using scanning tunneling microscopy (STM) is presented. The frequency of the mechanical vibrations is tuned over nearly four decades and is centered around 10 Hz. The amplitude of the vibrations also changes over nearly three decades centered on 1 nm. The oscillating motion is generated in two ways: first, by scanning the STM tip on the surface and second, by scanning the bias voltage on the STM tip. The frequency and amplitude of the displaced freestanding graphene is quantitatively transformed to the frequency and strength of the locally generated pseudo-magnetic field for our specific geometry.
description: 14 pages, 2 figures
ความต้องการในการบูรณาการเนื้อหาเกี่ยวกับวัฒนธรรมในรายวิชาภาษาอังกฤษระดับมัธยมศึกษาตอนต้นของประเทศไทย
Creators: name: อติมา แก้วสอาด
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2018
Subjects: การสื่อสารระหว่างวัฒนธรรม
ทักษะการสื่อสารข้ามวัฒนธรรม
การบูรณาการสอนวัฒนธรรมกับภาษา

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 18, 1, 1-23
Characterization of a Brg1  hypomorphic allele demonstrates that genetic and biochemical activity are tightly correlated
Creators: name: Chandler, Ronald L
name: Bultman, Scott J
name: Magnuson, Terry
name: Zhang, Ying
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Mammalian SWI/SNF-related complexes are recruited to the promoters of numerous target genes, and the BRG1 catalytic subunit confers ATPase activity necessary to slide or evict nucleosomes and to regulate transcription. Based on gene-targeting experiments in mice, BRG1 is essential for early embryonic development. However, Brg1 null mutants have provided limited insight into gene-dosage considerations and structure-function relationships. To extend our knowledge of BRG1 function, we describe the genetic and biochemical characteristics of an ENU-induced hypomorphic mutation that encodes a protein with a single amino-acid substitution (E1083G) within the bilobal ATPase/chromatin-remodeling domain. Brg1ENU1/ENU1 mice have ~50% genetic activity and survive embryogenesis but exhibit a postnatal developmental phenotype associated with runting and incompletely penetrant lethality. The E1083G mutant protein is stable, and experiments with recombinant FLAG-tagged BRG1 proteins demonstrated that it retains full ATPase activity. Yet the biochemical activity of the mutant protein is diminished to ~50% of normal in chromatin-remodeling assays. Consistent with these findings, the E1083G substitution is predicted to disrupt a structurally conserved α-helix within the lobe that participates in DNA translocation but does not contain the ATPase catalytic site. We propose that this α-helix participates in the DNA translocation cycle by mechanistically linking DNA interaction surfaces at the DNA entry/anchor point to those within the Helicase C domain of lobe 2 of the bilobal ATPase motor. Taken together, these results demonstrate that BRG1 genetic and biochemical activities are tightly correlated. They also indicate that BRG1 ATPase activity is necessary but not sufficient for chromatin remodeling.
Molecfit: A general tool for telluric absorption correction II. Quantitative evaluation on ESO-VLT X-Shooter spectra
Creators: name: Kausch, W.
name: Smette, S. Noll. A.
name: Kimeswenger, S.
name: Barden, M.
name: Szyszka, C.
name: Jones, A. M.
name: Sana, H.
name: Horst, H.
name: Kerber, F.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Context: Absorption by molecules in the Earth's atmosphere strongly affects ground-based astronomical observations. The resulting absorption line strength and shape depend on the highly variable physical state of the atmosphere, i.e. pressure, temperature, and mixing ratio of the different molecules involved. Usually, supplementary observations of so-called telluric standard stars (TSS) are needed to correct for this effect, which is expensive in terms of telescope time. We have developed the software package molecfit to provide synthetic transmission spectra based on parameters obtained by fitting narrow ranges of the observed spectra of scientific objects. These spectra are calculated by means of the radiative transfer code LBLRTM and an atmospheric model. In this way, the telluric absorption correction for suitable objects can be performed without any additional calibration observations of TSS. Aims: We evaluate the quality of the telluric absorption correction using molecfit with a set of archival ESO-VLT X-Shooter visible and near-infrared spectra. Methods: Thanks to the wavelength coverage from the U to the K band, X-Shooter is well suited to investigate the quality of the telluric absorption correction with respect to the observing conditions, the instrumental set-up, input parameters of the code, the signal-to-noise of the input spectrum, and the atmospheric profiles. These investigations are based on two figures of merit, I_off and I_res, that describe the systematic offsets and the remaining small-scale residuals of the corrections. We also compare the quality of the telluric absorption correction achieved with moelcfit to the classical method based on a telluric standard star. (Abridged)
description: Acc. by A&A; Software available via ESO: http://www.eso.org/sci/software/pipelines/skytools/
Expressing Opinions: Interacting among self-efficacy, motivation, a collectivist culture and technology
Creators: name: Nantawan Chuarayapratib
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2018
Subjects: Discussion Board
a collectivist culture
self-efficacy

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 18, 1, 24-55
An Investigation of Content Validity in O-NET (English Subject) for the Upper Secondary Level (Matthayom 6)
Creators: name: Nelobol Nipakornkitti
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2018
Subjects: O-NET test
standardized test
high-stakes test
content validity
test-curriculum
alignment

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 18, 1, 56-75