cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
In silico screening of glycogen synthase kinase-3β targeted ligands against acetylcholinesterase and its probable relevance to Alzheimer’s disease
Creators: name: Jabir, Nasimudeen R.
name: Shakil, Shazi
name: Tabrez, Shams
name: Khan, Mohd Shahnawaz
name: Rehman, Md Tabish
name: Ahmed, Bakrudeen Ali
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Computational Biology

description: Alzheimer’s disease (AD) is a growing global health concern that affects 10% of the population aged above 65 years. A growing body of evidence indicates that multi-targeted drugs might be useful therapeutic options owing to the heterogeneity of AD pathology. The current study exploited advanced computational biology tools to identify ligands that might display effective binding to two protein targets in the context of AD. The present study used in silico virtual screening of small molecules library to identify effectiveness against two AD targets viz. acetyl cholinesterase (AChE) and glycogen synthase kinase-3β (GSK-3β). PyRX-Python prescription with AutodockVina was used to generate binding energy profiles. Further screening was accomplished using SwissADME and molecular interaction studies. The present study obtained 48 ligands (absolute binding energy >8 kcal/mol), by virtual screening of 100 ligands. Among those, 13 ligands (BRW, 6VK, 6Z5, SMH, X37, 55E, 65 A, IQ6, 6VL, 6VM, F1B, 6Z2 and GVP) were selected based on blood brain barrier (BBB) permeability, acceptable ADME properties as well as their molecular interaction profiles with the aforementioned AD-targets. The present study has predicted certain molecules that appear worthy to be tested for effectiveness against two AD targets, namely AChE and GSK-3β. However, the results warrant further wet laboratory validation, as computational studies are merely predictive in nature. This approach might be useful for future treatment of AD. Communicated by Ramaswamy H. Sarma
title: „Kunstblut wird nicht nur in Hollywood gebraucht“ – Auftritt der Lehrklinik in der Öffentlichkeit anlässlich der Landesgartenschau 2018 in Würzburg
Creators: name: Knochenhauer, Tim
name: Peter-Kern, Martina
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Inhalte und Ablauf des Medizinstudiums sind der Bevölkerung nur wenig bekannt. Deshalb nutzten wir als Team der Lehrklinik Würzburg das Angebot unserer Presseabteilung bei der Landesgartenschau im dortigen Wissenschaftspavillon unser Skills Lab zu präsentieren. Landesgartenschauen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 14. Internationales SkillsLab Symposium 2019
title: Subjektiver Wissenszuwachs durch Skillslab Sonographiekurse
Creators: name: Richter, Henrike
name: Ruland, Markus
name: Reschke, Marc
name: Schmitt, Fiona
name: Groetschel, Hanjo
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Die Sonographie ist ein Schlüsselelement in der klinischen Diagnostik. Im stationären Alltag werden fundierte Kenntnisse in der Sonographie häufig vorausgesetzt, jedoch erlernen die wenigsten Studierenden diese Fähigkeit vor Beginn ihrer Laufbahn als Arzt.     Neben [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 14. Internationales SkillsLab Symposium 2019
Additional file 1 of Human in silico trials for parametric computational fluid dynamics investigation of cerebrospinal fluid drug delivery: impact of injection location, injection protocol, and physiology
Creators: name: Khani, Mohammadreza
name: Burla, Goutham Kumar Reddy
name: Sass, Lucas R.
name: Arters, Ostin N.
name: Xing, Tao
name: Wu, Haiming
name: Martin, Bryn A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 1. Spatial-temporal experimental (EXP) and computational fluid dynamics (CFD) results. EXP results provided only for verification studies conducted for the ICV, CM, and LP case (Fig. 4). CFD results provided for all injection scenarios. Rows represent axial position along the model with a spacing of 380 microns (76 cm total model length) and top row representing the cranial end of the model. Columns represent time steps with a resolution of 900 ms per step (180 min total simulation time) and left column representing time = 0.
title: Abdominal examination trainer as a successful tool to enhance clinical skills learning
Creators: name: Kozinc, Špela
name: Kosi, Špela
name: Koštomaj, Urška
name: Mihevc, Matic
name: Petreski, Tadej
name: Bevc, Sebastjan
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Background: Simulation-based learning (SBL) has become an important part of medical education. SBL is defined as an artificial representation of a real-world process to achieve educational goals through experimental learning, feedback, and reflection. Based on similarity to real-life situations, simulators[for full text, please go to the a.m. URL]
description: 14. Internationales SkillsLab Symposium 2019
Additional file 1 of Co-payments and equity in care: enhancing hospitalisation policy for Palestine refugees in Lebanon
Creators: name: Valente de Almeida, Sara
name: Paolucci, Gloria
name: Seita, Akihiro
name: Ghattas, Hala
Publisher: name: figshare
Year: 2022
Subjects: Medicine
Biotechnology
Science Policy

description: Additional file 1 Supplementary proofs, maps, figures, tables.
Parameter-free dissipation in simulated sliding friction
Creators: name: Benassi, Andrea
name: Vanossi, Andrea
name: Santoro, Giuseppe E.
name: Tosatti, Erio
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Non-equilibrium molecular dynamics simulations, of crucial importance in sliding friction, are hampered by arbitrariness and uncertainties in the way Joule heat is removed. We implement in a realistic frictional simulation a parameter-free, non-markovian, stochastic dynamics, which, as expected from theory, absorbs Joule heat precisely as a semi-infinite harmonic substrate would. Simulating stick-slip friction of a slider over a 2D Lennard-Jones solid, we compare our virtually exact frictional results with approximate ones from commonly adopted empirical dissipation schemes. While the latter are generally in serious error, we show that the exact results can be closely reproduced by a viscous Langevin dissipation at the boundary layer, once the back-reflected frictional energy is variationally optimized.
Compendium theologice veritatis
Creators: name: [Unknown]
Publisher: name: [France?] : [publisher not identified]
Year: 2014

description: Manuscript on parchment.

 Text in a small gothic bookhand, lettered in 2 columns on both sides of leaves.

 Large and small initials in red and blue, chapter headings in red.

 First leaf wanting. Vellum binding.
title: Chirurgie & Orthopädie im MAMBA Skillslab
Creators: name: Pietz, Corinna
name: Schelp, Adrian
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Der Fachbereich Chirurgie und Orthopädie des Magdeburger Ausbildungszentrums für medizinische Basisfertigkeiten (MAMBA) bietet seinen Studierenden in verschiedenen Kursen die Möglichkeit, fachspezifische Fertigkeiten zu erlernen und auszubauen.    Materialien und Methoden:[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 14. Internationales SkillsLab Symposium 2019
Elastic electron-deuteron scattering and two-body current operators in the Light-Front Hamiltonian Dynamics
Creators: name: Frederico, Tobias
name: Marinho, J. Adnei
name: Pace, Emanuele
name: Salme`, Giovanni
Publisher: name: arXiv
Year: 2010
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The electromagnetic properties of the deuteron are investigated within a Light-Front Hamiltonian Dynamics framework, with a current operator that contains both one-body and two-body contributions. In this work, we are considering new two-body contributions, with a dynamical nature generated within a Yukawa model and a structure inspired by a recent analysis of the current operator, that acts on the three-dimensional valence component and fulfills the Ward-Takahashi identity. Preliminary results for the magnetic moment are shown.
description: 11 pages and 1 figure. Contribution to Light-Cone 2010, Valencia, June 14-18, 2010, to appear in PoS(LC2010)
title: Innere Medizin im MAMBA Skillslab
Creators: name: Musil, Jakob
name: Riedel, Jan Niklas
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Der Fachbereich Innere Medizin des Magdeburger Ausbildungszentrums für medizinische Basisfertigkeiten (MAMBA) hebt sich mit seinen studentisch geleiteten Peer Teaching Kursen durch innovative Simulationen und strukturierte Kurskonzepte hervor. Das fakultative Kursangebot vermittelt[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 14. Internationales SkillsLab Symposium 2019
title: 10 Jahre interdisziplinäres Skills Lab Maris – Das Skills Lab als Ort medizindidaktischer Professionalität und Innovationsentwicklung
Creators: name: Stibane, Tina
name: Schönbauer, Andrea
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Im Oktober 2008 wurde das Marburger interdisziplinäre Skills Lab Maris gegründet. Am Beginn seiner Entwicklung entstand ein konzeptioneller Rahmen, der für die Entwicklung der Institution entscheidend wurde. Die Säulen „Curriculare Lehre und praktische Prüfungen“,[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 14. Internationales SkillsLab Symposium 2019
Precision measurements in ion traps using slowly moving standing waves
Creators: name: Walther, A.
name: Poschinger, U.
name: Singer, K.
name: Schmidt-Kaler, F.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The present paper describes the experimental implementation of a measuring technique employing a slowly moving, near resonant, optical standing wave in the context of trapped ions. It is used to measure several figures of merit that are important for quantum computation in ion traps and which are otherwise not easily obtainable. Our technique is shown to offer high precision, and also in many cases using a much simpler setup than what is normally used. We demonstrate here measurements of i) the distance between two crystalline ions, ii) the Lamb-Dicke parameter, iii) temperature of the ion crystal, and iv) the interferometric stability of a Raman setup. The exact distance between two ions, in units of standing wave periods, is very important for motional entangling gates, and our method offers a practical way of calibrating this distance in the typical lab situation.
description: 7 pages, 5 figures
Rational design of 9-vinyl-phenyl noscapine as potent tubulin binding anticancer agent and evaluation of the effects of its combination on Docetaxel
Creators: name: Dash, Shruti Gamya
name: Suri, Charu
name: Nagireddy, Praveen Kumar Reddy
name: Kantevari, Srinivas
name: Naik, Pradeep Kumar
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Docetaxel (DOX) based combination therapy is a novel therapeutic strategy that attracts great interest in breast cancer treatment but its clinical utility got limited due to side effects. In contrast, noscapine, an antitussive drug showed antitumor activity against many cancers without any side effects that targets microtubules and attenuates its dynamic instability. In the quest for an increase in the anticancer activity of noscapine, we strategically designed a novel derivative, 9-vinyl phenyl noscapine (VPN), based on our in silico molecular docking and molecular dynamics simulation effort. Molecular docking of VPN and DOX onto microtubule revealed a docking score of −4.82 kcal/mol and −6.67 kcal/mol respectively, while the docking score of VPN was changed to −3.23 kcal/mol when it was docked onto the co-complex of tubulin-DOX. Further, the binding free energy (ΔGbind,PBSA) of VPN and DOX with tubulin showed −24.04 and −18.65 kcal/mol respectively, while the binding free energy of DOX was increased further in combination with VPN (ΔGbind, PBSA was reduced to −21.41 kcal/mol), denoting combination effect of both ligands. The IC50 value amounted to 30.17 µM and 19.92 µM for VPN and 0.621 µM and 0.193 µM for DOX, respectively for 48 h and 72 h. The dose dependent cytotoxicity of DOX has been reduced considerably with the combination dose regimen of VPN. Further, the combine effect of both the agents improved the apoptotic cell death 28.5% compared to single agent treatment 5.71% and 10.5% for VPN and DOX, respectively. Both agents bind effectively to tubulin in single and in combination to interfere with cell cycle progression in G2/M transition. This study provides novel concept of combination treatment of DOX and VPN to amend efficiency in breast cancer treatment. Communicated by Ramaswamy H. Sarma
title: Evaluation hygienisches Palpieren im Verlaufe des Studiums: Hilft Praxiserfahrung für das Anwenden hygienischer Standards?
Creators: name: Schreiber, Jakob
name: Brinkmann, Julian
name: Annika, Meyer
name: Stosch, Christoph
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Während des Studiums der Humanmedizin an der Universität zu Köln absolvieren die Studenten zwei praktische Prüfungen in Form der Objective Structured Clinical Examination (OSCE). OSCE I im Fachsemester 5 ist als Famulaturreifeprüfung „formativ“, während[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 14. Internationales SkillsLab Symposium 2019
Additional file 1 of Sex, age, and ethnic dependency of lipoprotein variants as the risk factors of ischemic heart disease: a detailed study on the different age-classes and genders in Tehran Cardiometabolic Genetic Study (TCGS)
Creators: name: Lanjanian, Hossein
name: Najd Hassan Bonab, Leila
name: Akbarzadeh, Mahdi
name: Moazzam-Jazi, Maryam
name: Zahedi, Asiyeh Sadat
name: Masjoudi, Sajedeh
name: Daneshpour, Maryam S.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Table S1. The results of r2 calculation of Linkagedisequilibrium (LD) for all investigated SNPs in this study.
title: „Fit für das Patientenzimmer“: Entwicklung und Darstellung eines neuen Kurskonzeptes zur praktischen Vorbereitung für Medizinstudierende auf Hygienestandards in der Klinik
Creators: name: Hormann, Julia
name: Skiba, Lena
name: Nockelmann, Laura
name: Rubin, Dennis
name: Schulze, Christina
name: Achenbach, Jannis
name: Thomas, Michaela
name: Schäfer, Thorsten
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Hygienisches korrektes Verhalten am Arbeitsplatz gehört zu den wichtigsten medizinischen Skills für angehende Mediziner. Während die theoretische Wissensvermittlung ein fester Bestandteil der curricularen Lehre ist, fällt die Umsetzung und Implementierung in der Praxis[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 14. Internationales SkillsLab Symposium 2019
Additional file 1 of Long-term individualized monitoring of sympatric bat species reveals distinct species- and demographic differences in hibernation phenology
Creators: name: Meier, Frauke
name: Grosche, Leo
name: Reusch, Christine
name: Runkel, Volker
name: van Schaik, Jaap
name: Kerth, Gerald
Publisher: name: figshare
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Additional file 1: Table S1. Provides a summary of observed LHP entrance dates, emergence dates and durations. Table S2. Provides calender dates of estimated LHP entrance and emergence and durations as well as ranges between minimum and maximum values during our seven year study period.
Attendance at Catholic formal religious education programs by children and youth in 1974 and 1975. By Wilfrid H. Paradis and Andrew D. Thompson.
Creators: name: Paradis, Wilfrid H.
Publisher: name: University of Notre Dame
Year: 2023

description:
 An update of ʻWhere are the 6.6 million?ʼ--[t.p.].
 Cover title.
High-throughput virtual screening approach involving pharmacophore mapping, ADME filtering, molecular docking and MM-GBSA to identify new dual target inhibitors of PfDHODH and PfCytbc1 complex to combat drug resistant malaria
Creators: name: Rawat, Ravi
name: Verma, Saurabh M.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Emerging cases of drug resistance against Artemisinin combination therapies which are the current and the last line of defense against malaria makes the situation very alarming. Due to the liability of single-target drugs to be more prone to drug resistance, the trend of development of dual or multi-target inhibitors is emerging. Recently, a malaria box molecule, MMV007571 which is a well known new permeability pathways inhibitor was investigated to be also multi-targeting Plasmodium falciparum dihydroorotate dehydrogenase and cytochrome bc1 complex. The aspiration behind this study was to use the information of its pharmacophoric features essential for binding as two of its new targets. In this regard, high throughput virtual screening involving pharmacophore mapping, ADME filtering, molecular docking, and MM-GBSA calculations were carried out. This approach has lead to the identification of two new hits namely DT00V1902 and DT00V1922 which binds with -37.85 and -24.65 kcal/mol of more stable ΔG Bind energy at two targets than the lead molecule, MMV007571. The screened compounds are indicated to be carry improvement in binding potential and pharmacokinetic characters as per in silico studies. The authors propose that DT00V1902 and DT00V1922 can be forwarded for experimental validation and clinical studies for antimalarial chemotherapy. Communicated by Ramaswamy H. Sarma
Moments of the Gaussian Chaos
Creators: name: Lehec, Joseph
Publisher: name: arXiv
Year: 2010
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: This paper deals with Latała's estimation of the moments of Gaussian chaoses. It is shown that his argument can be simplified significantly using Talagrand's generic chaining.
description: 12 pages, file might be slightly different from the published version
title: Personal- und Prozessmanagement im Rahmen der Vermittlung ärztlich-praktischer Fertigkeiten in einer multizentrischen Skills Labs Einrichtung
Creators: name: Achenbach, Jannis
name: Thomas, Michaela
name: Schäfer, Thorsten
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: In speziell für die Vermittlung und Aneignung ärztlich-praktischer Fertigkeiten ausgestatteten Simulationsräumen können Studierende der Medizinischen Fakultät der Ruhr-Universität Bochum an insgesamt sieben Standorten Lernumgebungen finden.
    Mit dezentral[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 14. Internationales SkillsLab Symposium 2019
New tools and approaches for computational protein design
Creators: name: Blacklock, Kristin
Publisher: name: No Publisher Supplied
Year: 2019

description: This dissertation describes the development, benchmarking, validation, and application of computational methods, mostly written within the Rosetta suite of macromolecular modeling software, for the design and/or analysis of proteins. The introductory chapter brings the reader into the historical context of computational protein design, while detailing important concepts referenced in subsequent chapters.The second chapter is comprised of a benchmarking study of “LooDo”, a computational algorithm for the design of novel nested-domain proteins, which are proteins where one domain is inserted into another. This algorithm, named after its primary sampling method of loop-directed domain placement, was shown to be able to recapitulate native domain orientations for a benchmark set of five nested-domain proteins, as well as recapitulate domain-domain interface sequences and rank native versus nonnative domain combinations highly.In the next chapter, to improve the therapeutic ratio of the yeast cytosine deaminase (yCD)/5-fluorocytosine (5FC) directed-enzyme prodrug therapy system for targeted chemotherapy, we hypothesized that light-induced structural changes in yCD via bifunctional azobenzene derivative cross-linking would allow for the design of a photoswitchable yCD enzyme. Using generalizable computational design methods and experimental validation, we present one such design that allowed for a roughly 2-fold increase in activity towards cytosine under UV versus blue light stimuli.The fourth chapter presents a study in which the Rosetta and Amber energy functions are systematically compared by their performance in two structural evaluation tests and afterwards combined to increase the overall performance over both individually. The minimum-sum-of-ranks method employed in this chapter reduces the RMSD of the selected decoy by 1Å in 14 cases for the ff14SBonlySC energy function in Amber and 13 cases for the current Rosetta energy function, REF2015, in a large decoy discrimination benchmark test.The final chapter investigates bioisosteric alternatives to Axitinib in order to reduce the metabolic vulnerability of the heteroaryl thioether group. Using QM calculations, Rosetta docking protocols, and Amber molecular dynamics simulations, this study computationally evaluates four proposed structures by their predicted behaviors within the VEGFR2 kinase and ABL1 T315I gatekeeper mutant kinase binding pockets.Together, the work herein represents a collection of developments in the fields of computational biology and protein design.
Additional file 2 of Long-term individualized monitoring of sympatric bat species reveals distinct species- and demographic differences in hibernation phenology
Creators: name: Meier, Frauke
name: Grosche, Leo
name: Reusch, Christine
name: Runkel, Volker
name: van Schaik, Jaap
name: Kerth, Gerald
Publisher: name: figshare
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Additional file 2: Figures S1–S3. Provides boxplots of observed LHP entrance (1), emergance (2) and duration (3) split per year and significance levels resulting from the Games-Howell test.
$α$-particle condensate states in $^{16}$O
Creators: name: Ohkubo, S.
name: Hirabayashi, Y.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The existence of a rotational band with the $α$+$^{12}$C($0_2^+$) cluster structure, in which three $α$ particles in $^{12}$C($0_2^+$) are locally condensed, is demonstrated near the four-$α$ threshold of $^{16}$O in agreement with experiment. This is achieved by studying structure and scattering for the $α$+$^{12}$C($0_2^+$) system in a unified way. A drastic reduction (quenching) of the moment of the inertia of the $0^+$ state at 15.1 MeV just above the four-$α$ threshold in $^{16}$O suggests that it could be a candidate for the superfluid state in $α$-particle condensation.
description: 5 pages, 3 figures
A direct proof of the functional Santalo inequality
Creators: name: Lehec, Joseph
Publisher: name: arXiv
Year: 2010
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 26D15 (52A40)

description: We give a simple proof of a functional version of the Blaschke-Santalo inequality due to Artstein, Klartag and Milman. The proof is by induction on the dimension and does not use the Blaschke-Santalo inequality.
description: 4 pages, file might be slighlty different from the published version
New expression for the K-shell ionization
Creators: name: Santos, J. P.
name: Guerra, M.
name: Parente, F.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: A new expression for the total K-shell ionization cross section by electron impact based on the relativistic extension of the binary encounter Bethe (RBEB) model, valid from ionization threshold up to relativistic energies, is proposed. The new MRBEB expression is used to calculate the K-shell ionization cross sections by electron impact for the selenium atom. Comparison with all, to our knowledge, available experimental data shows good agreement.
Structure based design of inhibitory peptides targeting ornithine decarboxylase dimeric interface and in vitro validation in human retinoblastoma Y79 cells
Creators: name: Muthukumaran, Sivashanmugam
name: Sulochana, K. N.
name: Umashankar, Vetrivel
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Hematology

description: Polyamine synthesis in human cells is initiated by catalytic action of Ornithine decarboxylase (ODC) on Ornithine. Elevated levels of polyamines are manifested proliferating cancer cells and are found to promote tumour cell adhesion. Di-flouro methyl orninthine is a known inhibitor of ODC, however its usage is limited due its low affinity quick clearance and incompetent cellular uptake, thus posing a need for potential inhibitors. Currently, peptides are substituting drugs, as these are highly selective, specific and potent. Hence, in this study, the interacting interfaces of native homodimeric form of ODC and its heterodimer with Antizyme were probed to design inhibitory peptides targeting ODC. The designed peptides were validated for structural fitness by extensive molecular dynamics simulations and Circular dichroism studies. Finally, these peptides were validated in Y79 retinoblastoma cells for impact on ODC activity, cytotoxicity cell cycle and cell adhesion. On collective analysis, Peptide3 (Pep 3) and Peptide4 (Pep 4) were found to be potentially targeting ODC, as these peptides showed significant decrease in intracellular polyamine levels, cell adhesion and cell cycle perturbation in Y79 cells. Thus, Pep 3 and Pep 4 shall be favourably considered as therapeutic agents for targeting ODC mediated proliferation in retinoblastoma. Communicated by Ramaswamy H. Sarma
Modification of nuclear transitions in stellar plasma by electronic processes: K-isomers in 176Lu and 180Ta under s-process conditions
Creators: name: Gosselin, G.
name: Morel, P.
name: Mohr, P.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The influence of the stellar plasma on the production and destruction of K-isomers is studied for the examples 176Lu and 180Ta. Individual electromagnetic transitions are enhanced predominantly by nuclear excitation by electron capture, whereas the other mechanisms of electron scattering and nuclear excitation by electron transition give only minor contributions. It is found that individual transitions can be enhanced significantly for low transition energies below 100 keV. Transitions with higher energies above 200 keV are practically not affected. Although one low-energy transition in 180Ta is enhanced by up to a factor of 10, the stellar transition rates from low-K to high-K states via so-called intermediate states in 176Lu and 180Ta do not change significantly under s-process conditions. The s-process nucleosynthesis of 176Lu and 180Ta remains essentially unchanged.
description: 10 pages, 10 figures, Phys. Rev. C, accepted
Riparian forest management and regeneration : effects on forest structure and stream ecological processes in streams of eastern Amazon, Brazil
Creators: name: Rossetti De Paula, Felipe
Publisher: name: University of British Columbia
Year: 2018

description: In tropical areas, deforestation and forest degradation are major threats to forests and the surrounding ecosystems, such as riparian forests and streams. These threats to riparian forests and streams in agricultural areas can be reduced by the implementation of riparian buffers. However, disturbances from cleared areas may still impact the forests due to the high edge-to-area ratio of buffers. Selective logging inside the buffers also has the potential to degrade riparian forests and streams. Forest regeneration has the potential to restore ecosystems in degraded lands, but disturbances from ongoing agriculture are expected to arrest or delay the regeneration process in the buffers. I evaluated the efficacy of two riparian buffer management strategies: (1) land abandonment for natural regeneration and (2) the maintenance of mature forest. I also sampled additional sites of different ages to evaluate where buffer treatments fit after riparian forest alterations. I hypothesized that the riparian buffers resulting from land abandonment would have less forest canopy, simpler stand structure, less large wood, higher primary production, and higher decomposition rates than a regenerated riparian forest that was surrounded by mature forest. I expected the same outcomes when comparing the riparian buffers of mature forest versus mature riparian reference sites. I found that forest structure did not differ significantly between riparian buffer management treatments, however, my ordination analysis revealed signs of forest degradation after selective logging in the riparian buffers of mature forest. I found no significant effect of riparian buffer management in any stream variable studied. Large wood was related to channel width and stem density. Stream respiration increased and primary production decreased as the regeneration process advances. Decomposition differed among species, apparently by differences on leaf structural compounds. My results show that both buffer management strategies can be effective for protection of riparian and stream ecosystem in agricultural landscapes. Land abandonment is a viable and inexpensive restoration action where ongoing disturbances are mild and the propagules for regeneration are available. While the implementation of riparian buffers of mature forests is an effective strategy, selective logging should be excluded from these areas as disturbances may intensify in the future.
Encouraging rational antibiotic prescribing behaviour in primary care – prescribing practice among children aged 0–4 years 2016–2018: an observational study
Creators: name: Gunnlaugsdottir, Maria Run
name: Linnet, Kristjan
name: Jonsson, Jon Steinar
name: Blondal, Anna Bryndis
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: To study antibiotic prescriptions among 0- to 4-year-old children before and after implementing a quality project on prudent prescribing of antibiotics in primary healthcare in the capital region of Iceland. An observational, descriptive, retrospective study using quantitative methodology. Primary healthcare in the Reykjavik area with a total population of approximately 220,000. A total of 6420 children 0–4 years of age presenting at the primary healthcare centres in the metropolitan area over three years from 2016 to 2018. Reduction of antibiotic prescriptions and change in antibiotic profile. Data on antibiotic prescriptions for children 0–4 years of age was obtained from the medical records. Out-of-hours prescriptions were not included in the database. The number of prescriptions during the study period ranged from 263.6 to 289.6 prescriptions/1000 inhabitants/year. A reduction of 9% in the total number of prescriptions between 2017–2018 was observed. More than half of all prescriptions were for otitis media, followed by pneumonia and skin infections. Amoxicillin accounted for over half of all prescriptions, increasing between 2016 and 2018 by 51.3%. During this period, the prescribing of co-amoxiclav and macrolides decreased by 52.3% and 40.7%, respectively. These changes were significant in all cases, p The results show an overall decrease in antibiotic prescribing concurrent with a change in the choice of antibiotics prescribed and in line with the recommendations presented in the prescribing guidelines implemented by the Primary Healthcare of the Capital Area, and consistent with the project’s goals.Key pointsA substantial proportion of antibiotic prescribing can be considered inappropriate and the antibiotic prescription rate is highest in Iceland of the Nordic countries.After implementing guidance on the treatment of common infections together with feedback on antibiotic prescribing, a decrease in the total number of prescriptions accompanied by a shift in the antibiotic profile was observed. A substantial proportion of antibiotic prescribing can be considered inappropriate and the antibiotic prescription rate is highest in Iceland of the Nordic countries. After implementing guidance on the treatment of common infections together with feedback on antibiotic prescribing, a decrease in the total number of prescriptions accompanied by a shift in the antibiotic profile was observed.
Failure of t-J models in describing doping evolution of spectral weight in x-ray scattering, optical and photoemission spectra of the cuprates
Creators: name: Markiewicz, R. S.
name: Das, Tanmoy
name: Bansil, A.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We have analyzed experimental evidence for an anomalous transfer of spectral weight from high to low energy scales in both electron and hole doped cuprates as a function of doping. X-ray scattering, optical and photoemission spectra are all found to show that the high energy spectral weight decreases with increasing doping at a rate much faster than predictions of the large $U-$limit calculations. The observed doping evolution is however well-described by an intermediate coupling scenario where the effective Hubbard $U$ is comparable to the bandwidth. The experimental spectra across various spectroscopies are inconsistent with fixed-$U$ exact diagonalization or quantum Monte Carlo calculations, and suggest a significant doping dependence of the effective $U$ in the cuprates.
description: Accepted for Phys. Rev. B (2010). 7 pages, 4 figures
Electrifying Tax Reforms: Harmonizing HS Codes and Recommendations for East Africa's E-Mobility Transition
Creators: name: Kemei, Dominic Kibet
Publisher: name: Zenodo
Year: 2025

description: This policy brief analyzes the fragmented import duty, tax, and Harmonized System (HS) code landscape for electric vehicles (EVs) in the East African Community (EAC). It identifies key inconsistencies, particularly for electric two-wheelers (e-bicycles vs. e-motorcycles) and Completely Knocked Down (CKD) kits, which hinder the e-mobility transition. The brief provides recommendations for harmonizing tariffs/taxes, standardizing HS codes with specific E2W sub-categories, defining technical standards, streamlining incentives, aligning regional policies, and offers specific regulatory proposals for Kenya. The goal is to foster a coherent environment supporting sustainable e-mobility growth in East Africa. Prepared under the AFTER project (FCDO/CCG funded).
title: Peer-assisted learning: Das Lehrkonzept des modularen „Untersuchungstutoriums“ zur Aneignung einer ärztlich-körperlichen Untersuchung und dessen Evaluationsauswertung
Creators: name: Giotis, Nektaria
name: Achenbach, Jannis
name: Wüstefeld, Julia
name: Höthker, Julia
name: Thomas, Michaela
name: Schäfer, Thorsten
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Die Skills Labs der Ruhr-Universität Bochum fungieren in der medizinischen Ausbildung als integraler Bestandteil für die Aneignung praktisch relevanter Untersuchungstechniken. Als Vorteil gilt dabei die Möglichkeit der Abbildung realer klinischer Situationen, die insgesamt[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 14. Internationales SkillsLab Symposium 2019
Additional file 1 of Epidemiology of emergency ambulance service calls related to COVID-19 in Scotland: a national record linkage study
Creators: name: Fitzpatrick, David
name: Duncan, Edward A. S.
name: Moore, Matthew
name: Best, Catherine
name: Andreis, Federico
name: Esposito, Martin
name: Dobbie, Richard
name: Corfield, Alasdair R.
name: Lowe, David J.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Protocol 36 COVID-19 status by SIMD quintile.
title: Vermittlung von technischen Fertigkeiten: Peer-Teaching Konzepte und deren Evaluation zur Aneignung von „Skills“ zur Blutentnahme & Co.
Creators: name: Jahns, Roxana
name: Skiba, Lena
name: Achenbach, Jannis
name: Thomas, Michaela
name: Schäfer, Thorsten
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: In den Skills Labs der Ruhr-Universität Bochum werden insgesamt in drei thematisch-inhaltlichen Bereichen extracurriculare Kurse für Studierende der Medizinischen Fakultät angeboten. Dies sind Kurse aus folgenden Bereichen: Notfalltutorien, Untersuchungstutorien, Technische[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 14. Internationales SkillsLab Symposium 2019
Nonequilibrium Atom-Dielectric Forces Mediated by a Quantum Field
Creators: name: Behunin, Ryan Orson
name: Hu, Bei-Lok
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In this paper we give a first principles microphysics derivation of the nonequilibrium forces between an atom, treated as a three dimensional harmonic oscillator, and a bulk dielectric medium modeled as a continuous lattice of oscillators coupled to a reservoir. We assume no direct interaction between the atom and the medium but there exist mutual influences transmitted via a common electromagnetic field. By employing concepts and techniques of open quantum systems we introduce coarse-graining to the physical variables - the medium, the quantum field and the atom's internal degrees of freedom, in that order - to extract their averaged effects from the lowest tier progressively to the top tier. The first tier of coarse-graining provides the averaged effect of the medium upon the field, quantified by a complex permittivity (in the frequency domain) describing the response of the dielectric to the field in addition to its back action on the field through a stochastic forcing term. The last tier of coarse- graining over the atom's internal degrees of freedom results in an equation of motion for the atom's center of mass from which we can derive the force on the atom. Our nonequilibrium formulation provides a fully dynamical description of the atom's motion including back action effects from all other relevant variables concerned. In the long-time limit we recover the known results for the atom-dielectric force when the combined system is in equilibrium or in a nonequilibrium stationary state.
description: 24 pages, 2 figures
title: In 7 Stufen vom Tutoriat zum Peer Assessment: Das Ulmer Ausbildungscurriculum für Skills Lab-Tutor(inn)en
Creators: name: Kürten, Pauline
name: Messerer, David A. C.
name: Denzinger, Maximilian
name: Friz, Patrick
name: Böckers, Anja
name: Grab, Claudia
name: Horneffer, Astrid
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Das Skills Lab der Universität Ulm bietet vor allem Studierenden der klinischen Semester die Möglichkeit, im Rahmen freier Übungsabende verschiedene praktische Fertigkeiten zu trainieren. Darüber hinaus können Studierende auf freiwilliger Basis sogenannte Praxis-Checks[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 14. Internationales SkillsLab Symposium 2019
Extraction and characterization of metabolites from Olea europaea pulp and their molecular docking against SARS-CoV-2 main-protease (Mpro)
Creators: name: Ragunathan, Venkataraghavan
name: Chithra, K.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: The present study is the first to extract the bioactive metabolites from Olea europaea fruit using the Soxhlet-maceration extraction method. The preliminary phytochemical; Fourier transform-infrared spectroscopy (FT-IR); gas chromatography-mass spectrometry (GC-MS) analyses, and their potential against SARS-CoV-2 Mpro through molecular docking were studied. The preliminary qualitative phytochemical analyses showed coumarin glycosides, tannins, terpenoids, cholesterol, carbohydrates, and proteins. FT-IR spectroscopy revealed C-H, C = O, O-H, C-N, C-O-C, C-O, CO-O-CO, C = C, and C-Br functional groups in the extract. GC-MS analysis was done and the compounds detected were docked against SARS-CoV-2 Mpro using AutoDock Vina.The squalene (ΔG = −6.2 kcal/mol) posed the best inhibition potential and was comparable with the control drug remdesivir. The compounds possessed excellent pharmacokinetic and toxicity properties and are safe and reliable. Thus, the present research unveiled the valuable metabolites from O. europaea and their antiviral potential against the SARS-CoV-2.
title: Notfallmedizin im MAMBA Skillslab
Creators: name: Brinkema, Hanno
name: Mühlen, Lars
name: Leschowski, Niklas
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Das MAMBA Skillslab Magdeburg verfügt über ein vielfältiges Angebot an notfallmedizinischen Kurskonzepten. Neben den verbreiteten Basic Life Support (BLS)- und Advanced Life Support (ALS)-Kursen existieren auch Veranstaltungen zur Reanimation von Säuglingen oder der [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 14. Internationales SkillsLab Symposium 2019
title: AG Notfallmedizin im MAMBA Skillslab
Creators: name: Brinkema, Hanno
name: Riedel, Jan Niklas
name: Pietz, Corinna
name: Schelp, Adrian
name: Leschowski, Niklas
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Studierende der medizinischen Fakultät der Otto-von-Guericke Universität Magdeburg (OvGU) betreiben seit 2015 eine studentisch geleitete AG-Notfallmedizin (AGNMD). Im Laufe der Jahre hat die AG stark von einer engen Kooperation mit dem MAMBA Skillslab profitiert und dient als [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 14. Internationales SkillsLab Symposium 2019
Coherent excitation of a single atom to a Rydberg state
Creators: name: Miroshnychenko, Y.
name: Gaëtan, A.
name: Evellin, C.
name: Grangier, P.
name: Comparat, D.
name: Pillet, P.
name: Wilk, T.
name: Browaeys, A.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present the coherent excitation of a single Rubidium atom to the Rydberg state (58d3/2) using a two-photon transition. The experimental setup is described in detail, as well as experimental techniques and procedures. The coherence of the excitation is revealed by observing Rabi oscillations between ground and Rydberg states of the atom. We analyze the observed oscillations in detail and compare them to numerical simulations which include imperfections of our experimental system. Strategies for future improvements on the coherent manipulation of a single atom in our settings are given.
Additional file 2 of Epidemiology of emergency ambulance service calls related to COVID-19 in Scotland: a national record linkage study
Creators: name: Fitzpatrick, David
name: Duncan, Edward A. S.
name: Moore, Matthew
name: Best, Catherine
name: Andreis, Federico
name: Esposito, Martin
name: Dobbie, Richard
name: Corfield, Alasdair R.
name: Lowe, David J.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2. Predictive value of Protocol 36 of COVID-19 status across the 5 month study period.
EDUCATION IS ONE OF THE MOST IMPORTANT COMPONENT OF THE DEVELOPMENT OF YOUNG GENERATION
Creators: name: Shirin Daniyarovna Iskanderova Student of Samarkand State Institute of Foreign Languages, Samarkand, Uzbekistan
Publisher: name: Zenodo
Year: 2025

description: The article draws attention to the importance of education in the development of the young generation. The author emphasizes that education plays an important role in the formation of personality, the disclosure of potential and provides opportunities for further success in life.

Key words: education, knowledge, youth development, importance of education, skills, teaching, educational technologies, learning and innovation
title: Bereit, ein Leben zu retten?
Creators: name: Lehmanski, Franziska
name: Nübel, Jonathan
name: Sprenger, Matthias
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Die Reanimation ist als grundlegende Fertigkeit für angehende Mediziner*innen im Curriculum des Brandenburger Modellstudiengangs Medizin praktisch und theoretisch im ersten und fünften Semester verankert. Studierende können außerdem freiwillig an Tutorien des Skillslabs[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 14. Internationales SkillsLab Symposium 2019