cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Discrepancies in Kappa Opioid Agonist Binding Revealed through PET Imaging
Creators: name: Schroeder, F.A.
name: Che, T.
name: Wang, C.
name: Wey, H.-Y.
name: Placzek, M.S.
name: Roth, B.L.
name: Neelamegam, R.
name: Hooker, J.M.
Publisher: name: American Chemical Society
Year: 2019

description: Kappa opioid receptor (KOR) modulation has been pursued in many conceptual frameworks for the treatment of human pain, depression, and anxiety. As such, several imaging tools have been developed to characterize the density of KORs in the human brain and its occupancy by exogenous drug-like compounds. While exploring the pharmacology of KOR tool compounds using positron emission tomography (PET), we observed discrepancies in the apparent competition binding as measured by changes in binding potential (BP ND , binding potential with respect to non-displaceable uptake). This prompted us to systematically look at the relationships between baseline BP ND maps for three common KOR PET radioligands, the antagonists [ 11 C]LY2795050 and [ 11 C]LY2459989, and the agonist [ 11 C]GR103545. We then measured changes in BP ND using kappa antagonists (naloxone, naltrexone, LY2795050, JDTic, nor-BNI), and found BP ND was affected similarly between [ 11 C]GR103545 and [ 11 C]LY2459989. Longitudinal PET studies with nor-BNI and JDTic were also examined, and we observed a persistent decrease in [ 11 C]GR103545 BP ND up to 25 days after drug administration for both nor-BNI and JDTic. Kappa agonists were also administered, and butorphan and GR89696 (racemic GR103545) impacted binding to comparable levels between the two radiotracers. Of greatest significance, kappa agonists salvinorin A and U-50488 caused dramatic reductions in [ 11 C]GR103545 BP ND but did not change [ 11 C]LY2459989 binding. This discrepancy was further examined in dose-response studies with each radiotracer as well as in vitro binding experiments.
Intraislet glucagon signaling is critical for maintaining glucose homeostasis
Creators: name: Doliba, N.M.
name: Matschinsky, F.M.
name: Kaestner, K.H.
name: Barella, L.F.
name: Dattaroy, D.
name: Hochgeschwender, U.
name: Wess, J.
name: Wilkins, K.J.
name: Roth, B.L.
name: Cui, Y.
name: Pham, J.
name: Wang, L.
name: Zhu, L.
Publisher: name: American Society for Clinical Investigation
Year: 2019

description: Glucagon, a hormone released from pancreatic a cells, plays a key role in maintaining proper glucose homeostasis and has been implicated in the pathophysiology of diabetes. In vitro studies suggest that intraislet glucagon can modulate the function of pancreatic ß cells. However, because of the lack of suitable experimental tools, the in vivo physiological role of this intraislet cross-talk has remained elusive. To address this issue, we generated a mouse model that selectively expressed an inhibitory designer GPCR (Gi DREADD) in a cells only. Drug-induced activation of this inhibitory designer receptor almost completely shut o? glucagon secretion in vivo, resulting in markedly impaired insulin secretion, hyperglycemia, and glucose intolerance. Additional studies with mouse and human islets indicated that intraislet glucagon stimulates insulin release primarily by activating β cell GLP-1 receptors. These fndings strongly suggest that intraislet glucagon signaling is essential for maintaining proper glucose homeostasis in vivo. Our work may pave the way toward the development of novel classes of antidiabetic drugs that act by modulating intraislet cross-talk between a and ß cells.
Efficient Simulation-Based Minimum Distance Estimation and Indirect Inference
Creators: name: Nickl, Richard
name: Pötscher, Benedikt M.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Statistics Theory (math.ST)
subject: FOS: Mathematics

description: Given a random sample from a parametric model, we show how indirect inference estimators based on appropriate nonparametric density estimators (i.e., simulation-based minimum distance estimators) can be constructed that, under mild assumptions, are asymptotically normal with variance-covarince matrix equal to the Cramer-Rao bound.
description: Minor revision, some references and remarks added
How structure informs and transforms chemogenetics
Creators: name: Roth, B.L.
Publisher: name: Elsevier Ltd
Year: 2019

description: Chemogenetic technologies such as Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are widely used to remotely control neuronal and non-neuronal signaling. DREADDs exist for most of the canonical G protein-coupled receptor signaling pathways, and provide a synthetic biology platform useful for elucidating the role of neuronal signaling for brain function. Here, a focused review is provided that shows how recent insights obtained from GPCR structural studies inform our understanding of these chemogenetic tools from a structural perspective.
title: Region One Civil Aeronautics Administration News and Monthly Digest: March 1958
title: Region One News and Monthly Digest: March 1958
titleType: AlternativeTitle
Creators: name: United States Department of Commerce: Civil Aeronautics Administration
Publisher: name: United States Department of Transportation
publisherIdentifier: https://ror.org/02xfw2e90
publisherIdentifierScheme: ROR
Year: 1958
Subjects: classificationCode: https://trt.trb.org/term/92062
subject: Aviation
classificationCode: https://trt.trb.org/term/91623
subject: Personnel
classificationCode: https://trt.trb.org/term/88724
subject: Government funding
classificationCode: https://trt.trb.org/term/91634
subject: Government employees
classificationCode: https://trt.trb.org/term/90595
subject: Transportation safety
classificationCode: https://trt.trb.org/term/90596
subject: Aviation safety
classificationCode: https://trt.trb.org/term/88618
subject: Awards

description: See the Civil Aeronautics Administration Region One News and Monthly Digests finding aid at: https://ntl.as.atlas-sys.com/repositories/2/resources/46
description: Updates on activities and projects from each division (Airports; Air Carrier Safety; Air Traffic Control; Air Navigation Facilities; Aircraft Engineering; and General Safety) of Region One (the Eastern Region) Civil Aeronautics Administration employees.
Complete Characterization of Mixing Time for the Continuous Quantum Walk on the Hypercube with Markovian Decoherence Model
Creators: name: Drezgich, Milosh
name: Hines, Andrew P.
name: Sarovar, Mohan
name: Sastry, Shankar
Publisher: name: arXiv
Year: 2008
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The n-dimensional hypercube quantum random walk (QRW) is a particularily appealing example of a quantum walk because it has a natural implementation on a register on $n$ qubits. However, any real implementation will encounter decoherence effects due to interactions with uncontrollable degrees of freedom. We present a complete characterization of the mixing properties of the hypercube QRW under a physically relevant Markovian decoherence model. In the local decoherence model considered the non-unitary dynamics are modeled as a sum of projections on individual qubits to an arbitrary direction on the Bloch sphere. We prove that there is always classical (asymptotic) mixing in this model and specify the conditions under which instantaneous mixing \textit{always} exists. And we show that the latter mixing property, as well as the classical mixing time, depend heavily on the exact environmental interaction and its strength. Therefore, algorithmic applications of the QRW on the hypercube, if they intend to employ mixing properties, need to consider both the walk dynamics and the precise decoherence model.
description: 18 pages, 3 figures. Published version. Spelling of author name changed, no content changes in v4
Lumbar Catheter Placement Using Paramedian Approach Under Fluoroscopic Guidance
Creators: name: Zeenat Qureshi Stroke Institutes
Publisher: name: Zenodo
Year: 2023

description: Background—Lumbar catheter placement under fluoroscopic guidance may reduce the rate of technicalfailures and associated complications seen with insertion guided by manually palpable landmarks.Methods—We reviewed our experience with 43 attempted lumbar catheter placements using paramedianapproach under fluoroscopic guidance and ascertained rates of technical success, and clinical events.Results—Among the 43 patients, 18, 1, and 1 patients were on aspirin (with dipyrimadole in 2), clopidogrel, and combination of both, respectively. Lumbar catheter placement was successful in 42 of 43 attemptedplacements. Floroscopic guidance was critical in three patients; one patient had severe cerebrospinal fluid(CSF) depletion (empty thecal sac phenomenon) following pituitary surgery leading to no cerebrospinalfluid return despite correct placement confirmation under fluoroscopy. Two patients had spinal needleplacement at the junction between epidural and cerebrospinal fluid spaces (junctional position) leading tocerebrospinal fluid return but inability to introduce the lumbar catheter. After confirmation of position bythe injection of contrast or radiographic landmarks the needle was advanced by indenting the subcutaneoustissue or reinserting at a spinal level above the first insertion. The lumbar catheter remained in position overa mean period (±standard deviation) of 4.1(±2.3) days. Improvement in hydrocephalus was seen in twopatients with intracranial mass lesions. One patient developed cerebrospinal fluid leakage through the insertion track following removal of catheter and required skin suturing at the site of insertion.
Phosphoproteomics Illuminates Opioid Actions
Creators: name: Che, T.
name: Roth, B.L.
Publisher: name: American Chemical Society
Year: 2018

description: Opioids are widely used analgesic medications with a high potential for tolerance and dependence and represent a frequent cause of death due to overdose. Opioids mediate their actions via a family of opioid G protein coupled receptors. Elucidating the biochemical mechanism(s) responsible for both the therapeutic and deleterious side effects of opioids could provide a biochemical roadmap for selectively targeting therapeutic signaling pathways. Here we provide a perspective on emerging findings, which illuminate these signaling pathways via unbiased and quantitative phosphoproteomic analysis. What emerged from these studies is the discovery that certain deleterious actions mediated by the κ opioid receptors appear due to specific activation of mTOR pathways. The findings imply that designing drugs, which bypass mTOR signaling, could yield safer and more effective analgesics.
Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone
Creators: name: Wang, S.
name: Levit, A.
name: Shoichet, B.K.
name: Che, T.
name: Roth, B.L.
name: Wacker, D.
Publisher: name: Nature Publishing Group
Year: 2018

description: Dopamine is a neurotransmitter that has been implicated in processes as diverse as reward, addiction, control of coordinated movement, metabolism and hormonal secretion. Correspondingly, dysregulation of the dopaminergic system has been implicated in diseases such as schizophrenia, Parkinson's disease, depression, attention deficit hyperactivity disorder, and nausea and vomiting. The actions of dopamine are mediated by a family of five G-protein-coupled receptors. The D2 dopamine receptor (DRD2) is the primary target for both typical and atypical antipsychotic drugs, and for drugs used to treat Parkinson's disease. Unfortunately, many drugs that target DRD2 cause serious and potentially life-threatening side effects due to promiscuous activities against related receptors. Accordingly, a molecular understanding of the structure and function of DRD2 could provide a template for the design of safer and more effective medications. Here we report the crystal structure of DRD2 in complex with the widely prescribed atypical antipsychotic drug risperidone. The DRD2-risperidone structure reveals an unexpected mode of antipsychotic drug binding to dopamine receptors, and highlights structural determinants that are essential for the actions of risperidone and related drugs at DRD2. © 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
title: Region One Federal Aviation Agency News and Digest: July 1959
title: Region One News and Monthly Digest: July 1959
titleType: AlternativeTitle
Creators: name: Federal Aviation Administration
Publisher: name: United States Department of Transportation
publisherIdentifier: https://ror.org/02xfw2e90
publisherIdentifierScheme: ROR
Year: 1959
Subjects: classificationCode: https://trt.trb.org/term/92062
subject: Aviation
classificationCode: https://trt.trb.org/term/91623
subject: Personnel
classificationCode: https://trt.trb.org/term/91634
subject: Government employees
classificationCode: https://trt.trb.org/term/88724
subject: Government funding
classificationCode: https://trt.trb.org/term/88618
subject: Awards
classificationCode: https://trt.trb.org/term/90595
subject: Transportation safety
classificationCode: https://trt.trb.org/term/90596
subject: Aviation safety

description: See the Civil Aeronautics Administration Region One News and Monthly Digests finding aid at: https://ntl.as.atlas-sys.com/repositories/2/resources/46
description: Updates on activities and projects from each division (Airports; Air Carrier Safety; Air Traffic Control; Air Navigation Facilities; Aircraft Engineering; and General Safety) of Region One (the Eastern Region) Civil Aeronautics Administration employees.
A Simple Representation of Three-Dimensional Molecular Structure
Creators: name: Keiser, M.J.
name: Axen, S.D.
name: Roth, B.L.
name: Gendelev, L.
name: Huang, X.-P.
name: Cáceres, E.L.
Publisher: name: American Chemical Society
Year: 2017

description: Statistical and machine learning approaches predict drug-to-target relationships from 2D small-molecule topology patterns. One might expect 3D information to improve these calculations. Here we apply the logic of the extended connectivity fingerprint (ECFP) to develop a rapid, alignment-invariant 3D representation of molecular conformers, the extended three-dimensional fingerprint (E3FP). By integrating E3FP with the similarity ensemble approach (SEA), we achieve higher precision-recall performance relative to SEA with ECFP on ChEMBL20 and equivalent receiver operating characteristic performance. We identify classes of molecules for which E3FP is a better predictor of similarity in bioactivity than is ECFP. Finally, we report novel drug-to-target binding predictions inaccessible by 2D fingerprints and confirm three of them experimentally with ligand efficiencies from 0.442-0.637 kcal/mol/heavy atom. © 2017 American Chemical Society.
The effects of photoperiod and temperature on the daily pattern of locomotor activity in juvenile sockeye salmon, Oncorhynchus nerke (Walbaum)
Creators: name: Byrne, John Edward
Publisher: name: University of British Columbia
Year: 2011

description: Supervisor: N. R. Liley The endogenous and exogenous factors contributing to a diel rhythm of locomotor activity in juvenile sockeye salmon Oncorhynchus nerka (Walbaum) were examined in the laboratory. The basic measure employed in the investigation was spontaneous locomotor activity. High frequency sound (800 kHz) was used as a monitoring technique to collect continuous activity records. Three major areas received attention. First, a description and analysis were provided for the entrained diel activity pattern under three different temperatures (5°, 10°, and 15°C) and three different photoperiods (8L 16D, 12L 12D, and 16L 8D). The combined effects of temperature and photoperiod upon the basic 24 hour response were recorded and analyzed. Juvenile sockeye salmon were nocturnally active immediately after emergence from the gravel. A diurnal activity pattern was gradually acquired during the following 14 days and was maintained for 12 months. Photoperiod was the primary environmental synchronizer for either diurnal or nocturnal activity. The endogenous component of the activity rhythm was examined in constant environmental conditions. Constant light (34.4 lux at 10°C) facilitated the free-running response while constant dark inhibited it. The spontaneous frequency in constant light was 23.30 hours but this could be altered by light intensity or periodic feeding. The final experiments focused upon the relationship between the environmental stimulus (photoperiod) and the physiological sensory mechanisms mediating the entrained response. The eyes were the primary photoreceptors mediating information about the light-dark environment. The entrained activity response disappeared when the retina was not illuminated. When the pineal body was removed or shaded, juvenile sockeye responded with increased activity. Intraperitoneal injections of melatonin (N-acetyl-5-hydroxy-tryptamine) or serotonin (5-hydroxy-tryptamine) selectively altered the activity amplitude in either the light or dark respectively. Juvenile sockeye salmon possess an endogenous circadian activity rhythm which is synchronized by the photoperiodic cycle. The fish are generally light active, except for the period immediately after emergence. However, interactions between daylength and temperature can result in temporary dark active responses. Mediation of the photoperiodic information occurs via the retina, but without transmission by optic nerve pathways. Chemical agents (melatonin and serotonin) produced by the retina and/or pineal might control the activity amplitude in light and dark, thus resulting in the characteristic entrained pattern.
How Ligands Illuminate GPCR Molecular Pharmacology
Creators: name: Roth, B.L.
name: Stevens, R.C.
name: Wacker, D.
Publisher: name: Cell Press
Year: 2017

description: G protein-coupled receptors (GPCRs), which are modulated by a variety of endogenous and synthetic ligands, represent the largest family of druggable targets in the human genome. Recent structural and molecular studies have both transformed and expanded classical concepts of receptor pharmacology and have begun to illuminate the distinct mechanisms by which structurally, chemically, and functionally diverse ligands modulate GPCR function. These molecular insights into ligand engagement and action have enabled new computational methods and accelerated the discovery of novel ligands and tool compounds, especially for understudied and orphan GPCRs. These advances promise to streamline the development of GPCR-targeted medications. © 2017 Elsevier Inc.
Flexible shape models for image analysis in an automated lobster catch assessment system
Creators: name: Knights, MS
Publisher: name: University Of Tasmania
Year: 2023

description: Management of fisheries is an evolving science combining multiple techniques and strategies. The involvement of the computer in industry management and research continues to grow. The area of image analysis is currently limited but continues to grow as computing equipment becomes faster and cheaper. Locating a particular object in an image and processing information about that object is a significant task that requires a great deal of processing power and finesse. The benefits of a functioning automated task that processes data on an object, such as a lobster, simply by processing an image of that object would greatly enhance the ability to manage a fishery with accurate, up to date data. The Tasmanian Aquaculture and Fisheries Institute (TAFI) intend to create a lobster-sorting tray, which can be used on lobster fishing vessels as standard equipment. This tray would include functionality to take an image of the current lobster and estimate its sex and weight from pertinent measurements on the lobster. This research demonstrates that through the use of the Active Shape Modeller (ASM) these details can be identified and processed from an image of the lobster. The ASM is used within an image analysis process, which can be fully automated, to draw out the required salient details of a lobster from an area of interest in the images. A series of experiments showed that the ASM was able to draw out and fully identify 77.3% images in a test set of 216 images. These images then had pertinent lengths and a sex estimated based on these measurements where 90% of the matched lobsters were sexed correctly.
Discovery of new GPCR ligands to illuminate new biology
Creators: name: Irwin, J.J.
name: Roth, B.L.
name: Shoichet, B.K.
Publisher: name: Nature Publishing Group
Year: 2017

description: Although a plurality of drugs target G-protein-coupled receptors (GPCRs), most have emerged from classical medicinal chemistry and pharmacology programs and resemble one another structurally and functionally. Though effective, these drugs are often promiscuous. With the realization that GPCRs signal via multiple pathways, and with the emergence of crystal structures for this family of proteins, there is an opportunity to target GPCRs with new chemotypes and confer new signaling modalities. We consider structure-based and physical screening methods that have led to the discovery of new reagents, focusing particularly on the former. We illustrate their use against previously untargeted or orphan GPCRs, against allosteric sites, and against classical orthosteric sites that selectively activate one downstream pathway over others. The ligands that emerge are often chemically novel, which can lead to new biological effects. © 2017 Nature America, Inc., part of Springer Nature. All rights.
The mass profile of early-type galaxies in overdense environments: the case of the double source plane gravitational lens SL2SJ02176-0513
Creators: name: TU, H.
name: Gavazzi, R.
name: Limousin, M.
name: Cabanac, R.
name: Marshall, P. J.
name: Fort, B.
name: Treu, T.
name: Péllo, R.
name: Jullo, E.
name: Kneib, J. -P.
name: Sygnet, J. -F.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: SL2SJ02176-0513 is a remarkable lens for the presence of two multiply-imaged systems at different redshifts lensed by a foreground massive galaxy at $z_{\rm lens}=0.656$: a bright cusp arc at $z_{\rm arc}=1.847$ and an additional double-image system at an estimated redshift of $z_{\rm dbl}\sim2.9$ based on photometry and lensing geometry. The system is located about 400 kpc away from the center of a massive group of galaxies. Mass estimates for the group are available from X-ray observations and satellite kinematics. Multicolor photometry provides an estimate of the stellar mass of the main lens galaxy. The lensing galaxy is modeled with two components (stars and dark matter), and we include the perturbing effect of the group environment, and all available constraints. We find that classic lensing degeneracies, e.g. between external convergence and mass density slope, are significantly reduced with respect to standard systems and infer tight constraints on the mass density profile: (i) the dark matter content of the main lens galaxy is in line with that of typical galaxies $f_{\rm dm}(
description: 10 pages, 6 figures, submitted to A&A
5-HT2C Agonists Modulate Schizophrenia-Like Behaviors in Mice
Creators: name: Pogorelov, V.M.
name: Roth, B.L.
name: Huang, M.
name: Cheng, J.
name: Meltzer, H.Y.
name: Wetsel, W.C.
name: Rodriguiz, R.M.
name: Schmerberg, C.M.
name: Kozikowski, A.P.
Publisher: name: Nature Publishing Group
Year: 2017

description: All FDA-approved antipsychotic drugs (APDs) target primarily dopamine D2 or serotonin (5-HT2A) receptors, or both; however, these medications are not universally effective, they may produce undesirable side effects, and provide only partial amelioration of negative and cognitive symptoms. The heterogeneity of pharmacological responses in schizophrenic patients suggests that additional drug targets may be effective in improving aspects of this syndrome. Recent evidence suggests that 5-HT2C receptors may be a promising target for schizophrenia since their activation reduces mesolimbic nigrostriatal dopamine release (which conveys antipsychotic action), they are expressed almost exclusively in CNS, and have weight-loss-promoting capabilities. A difficulty in developing 5-HT2C agonists is that most ligands also possess 5-HT2B and/or 5-HT2A activities. We have developed selective 5-HT2C ligands and herein describe their preclinical effectiveness for treating schizophrenia-like behaviors. JJ-3-45, JJ-3-42, and JJ-5-34 reduced amphetamine-stimulated hyperlocomotion, restored amphetamine-disrupted prepulse inhibition, improved social behavior, and novel object recognition memory in NMDA receptor hypofunctioning NR1-knockdown mice, and were essentially devoid of catalepsy. However, they decreased motivation in a breakpoint assay and did not promote reversal learning in MK-801-treated mice. Somewhat similar effects were observed with lorcaserin, a 5-HT2C agonist with potent 5-HT2B and 5-HT2A agonist activities, which is approved for treating obesity. Microdialysis studies revealed that both JJ-3-42 and lorcaserin reduced dopamine efflux in the infralimbic cortex, while only JJ-3-42 decreased it in striatum. Collectively, these results provide additional evidence that 5-HT2C receptors are suitable drug targets with fewer side effects, greater therapeutic selectivity, and enhanced efficacy for treating schizophrenia and related disorders than current APDs. Neuropsychopharmacology advance online publication, 12 April 2017; doi:10.1038/npp.2017.52.
Lorcaserin and pimavanserin: Emerging selectivity of serotonin receptor subtype-targeted drugs
Creators: name: Meltzer, H.Y.
name: Roth, B.L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Serotonin (5-hydroxytryptamine, or 5-HT) receptors mediate a plethora of physiological phenomena in the brain and the periphery. Additionally, serotonergic dysfunction has been implicated in nearly every neuropsychiatric disorder. The effects of serotonin are mediated by fourteen GPCRs. Both the therapeutic actions and side effects of commonly prescribed drugs are frequently due to nonspecific actions on various 5-HT receptor subtypes. For more than 20 years, the search for clinically efficacious drugs that selectively target 5-HT receptor subtypes has been only occasionally successful. This review provides an overview of 5-HT receptor pharmacology and discusses two recent 5-HT receptor subtype-selective drugs, lorcaserin and pimavanserin, which target the 5HT2C and 5HT2A receptors and provide new treatments for obesity and Parkinson's disease psychosis, respectively.
title: Centric: June-September 1977
Creators: name: National Highway Traffic Safety Administration: National Center for Statistics and Analysis
Publisher: name: United States Department of Transportation
publisherIdentifier: https://ror.org/02xfw2e90
publisherIdentifierScheme: ROR
Year: 1977
Subjects: classificationCode: https://trt.trb.org/term/96717
subject: Statistics
subject: FOS: Mathematics
classificationCode: https://trt.trb.org/term/91623
subject: Personnel
classificationCode: https://trt.trb.org/term/97439
subject: Conferences
classificationCode: https://trt.trb.org/term/88648
subject: Continuing education
classificationCode: https://trt.trb.org/term/89022
subject: Contracts
classificationCode: https://trt.trb.org/term/90775
subject: Fatalities
classificationCode: https://trt.trb.org/term/93814
subject: Seat belts
classificationCode: https://trt.trb.org/term/93815
subject: Seat belt use
classificationCode: https://trt.trb.org/term/90601
subject: Traffic safety
classificationCode: https://trt.trb.org/term/90602
subject: Highway safety
classificationCode: https://trt.trb.org/term/92827
subject: Highways

description: Newsletter distributed by the National Highway Traffic Safety Administration, National Center for Statistics and Analysis covering current highway accident research.
Large polaron formation induced by Rashba spin-orbit coupling
Creators: name: Grimaldi, C.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Here the electron-phonon Holstein model with Rashba spin-orbit interaction is studied for a two dimensional square lattice in the adiabatic limit. It is demonstrated that a delocalized electron at zero spin-orbit coupling localizes into a large polaron state as soon as the Rashba term is nonzero. This spin-orbit induced polaron state has localization length inversely proportional to the Rashba coupling $γ$, and it dominates a wide region of the $γ$-$λ$ phase diagram, where $λ$ is the electron-phonon interaction.
description: 5 pages, 3 figures, version as published
Our Lady of Guadalupe: Sources in English
Creators: name: González, Frank
Publisher: name: Benson Latin American Collection
Year: 1996
Subjects: Mexican Americans--Religion
Mexican Americans in popular culture
Mexico

description: According to tradition, the Virgin of Guadalupe appeared to Juan Diego, an Indian, on a hill near the outskirts of Mexico City on a December morning in 1531. Before the Conquest, the site of her apparition, Tepeyac, had been a sacred place dedicated to the Aztec goddess, Tonantzin. Her image, imprinted on Juan Diego's mantle, was one of a brown-skinned madonna with pre-Columbian vestiges, and struck a chord with her early supplicants. A cult soon developed around "La Morenita." She was adopted as a symbol of Mexican nationalism, and has become a rallying point for political and social movements from the Mexican countryside of the insurgents to the fields of California's farmworkers. To her devotees, La Virgen de Guadalupe invokes faith, hope, and compassion; she embraces the cause of the poor, the ignored, the voiceless, the oppressed. In short, La Reina de México and Emperatriz de las Américas, as she is often referred to, has left a profound impact of the religious and cultural life of Mexicans and Mexican Americans.
Factors affecting capsule and seed set in Eucalyptus globulus seed orchards
Creators: name: Suitor, S
Publisher: name: University Of Tasmania
Year: 2023

description: Low capsule seed set is a major factor limiting seed production in Eucalyptus globulus seed orchards. Trials were conducted in two Tasmanian E. globulus seed orchards to identify mechanisms involved in capsule abortion and low reproductive success. Key areas of investigation included identification of the timing of abortion relative to stage of capsule development, the impact of irrigation management and other treatments imposed to alter resource allocation, the influence of the maternal and paternal genotype, and relationship between floral characteristics and propensity of capsules to abort.
Engineered G-protein coupled receptors are powerful tools to investigate biological processes and behaviors
Creators: name: Roth, B.L.
name: Nichols, C.D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Understanding how discreet tissues and neuronal circuits function in relation to the whole organism to regulate physiological processes and behaviors is a fundamental goal of modern biological science. Powerful and important new tools in this discovery process are modified G-protein coupled receptors (GPCRs) known as 'Receptors Activated Solely by Synthetic Ligands (RASSLs),' and 'Designer Receptors Exclusively Activated by a Designer Drug (DREADDs).' Collectively, these are GPCRs modified either through rational design (RASSLs) or directed molecular evolution (DREADDs), that do not respond to native ligand, but functionally respond only to synthetic ligands. Importantly, the utility of these receptors is not limited to examination of the role of GPCR-coupled effector signal transduction pathways. Due to the near ubiquitous expression of GPCRs throughout an organism, this technology, combined with whole animal transgenics to selectively target expression, has the ability to regulate activity of discreet tissues and neuronal circuits through effector pathway modulation to study function and behavior throughout the organism. Advantages over other systems currently used to modify in vivo function include the ability to rapidly, selectively and reversibly manipulate defined signal transduction pathways both in short term and long term studies, and no need for specialized equipment due to convenient systemic treatment with activating ligand. © 2009 Nichols and Roth.
Carnival in Brazil: Selected Sources
Creators: name: McCann, Katherine
Publisher: name: Benson Latin American Collection
Year: 1997
Subjects: Carnival--Brazil--Rio de Janeiro
Brazil--Social life and customs
Brazil

description: Carnival, the annual celebration before Lent, is perhaps the most widely attended of Brazilian festivals and certainly the most widely recognized internationally. Scholars and writers from various disciplines continue to examine Carnival, Carnaval in Portuguese, as both a reflection and a distortion of national identity. This bibliography is intended to help the reader locate materials that describe the history, music, and images of Carnival, and its role in Brazilian popular culture. Many more sources can be located through the General Libraries' online catalog, UTCAT.
Hercules and Augustus : Propertius 4.9: a political reading
Creators: name: Berry, Michael
Publisher: name: University Of Tasmania
Year: 2023

description: This thesis offers a political reading of Propertius 4.9 ‚Äö- Propertius' account of Hercules' arrival at the site of future Rome. Specifically, it argues that the ninth elegy in Propertius' fourth book provides a critique of Augustan propaganda surrounding the Battle of Actium (31 BC), the ensuing triple triumph (29 BC) and Augustus' later attempts at social, moral and poetic censorship. Central to the argument is the nature and extent of the relationship between Hercules and Augustus and Hercules' status as a paradigm for the princeps. Accordingly, the thesis begins with an investigation of this association, firstly, by examining the sources and, secondly, by analysing the affinity between 4.9 and the Aeneid ‚Äö- particularly the eighth book ‚Äö- where Hercules assumes such an exemplary role. Detailed readings of the elegy follow. The first word, Amphitryoniades, is examined closely as it sets the tone for the elegy as a whole and reaffirms Hercules' status as a model for Augustus. The first episode of the elegy ‚Äö- Hercules' conflict with Cacus ‚Äö- is then subjected to a close reading from the perspective that it functions as an allegorical representation of the Battle of Actium and, finally, Hercules' encounter with the worshippers of Bona Dea ‚Äö- the elegy's second episode ‚Äö- is given close attention. It is argued that this final episode offers a critique of Augustus' legislative reforms ‚Äö- namely the lex Iulia de maritandis ordinibus and the lex Iulia de adulteriis coercendis of 18 BC. The thesis thus reveals a hitherto overlooked critique of Augustus' rise to power and his attempts at social, moral and poetic censorship.
Erratum: Synthesis and receptor profiling of Stemona alkaloid analogues reveal a potent class of sigma ligands (Proceedings of the National Academy of Sciences of the United States of America (2011) 108, 17, (6727-6732) DOI: 10.1073/pnas.1016558108)
Creators: name: Frankowski, K.J.
name: Evans, J.M.
name: Neuenswander, B.
name: Roth, B.L.
name: Aubé, J.
name: Setola, V.
Publisher: name: National Academy of Sciences
Year: 2012

description: [No abstract available]
Cultural Magazines: Latin America and the Caribbean
Creators: name: Delepiani, Oscar E.
Publisher: name: Benson Latin American Collection
Year: 1997
Subjects: Latin American periodicals
Latin America--Civilization
Popular culture--Latin America

description: This bibliography is a guide to current cultural magazines in the Benson Latin American Collection. Cultural magazines, as defined here, are those containing articles on cultural topics related to the country of publication; that is, the arts, literature, history, and the humanities in general. These magazines, intended for the general reader, are usually published by cultural institutions, public or private, and by universities. They are often well illustrated and elegant in presentation, but of irregular frequency. To find additional similar periodicals in UTCAT, search the name of the country plus the words, "Civilization Periodicals" (Argentina Civilization Periodicals), as a subject in UTCAT, the online catalog. The most recent issues of the magazines which are starred (*) are located in the Periodicals Reading Area, shelved alphabetically under their titles, while older issues are in the Benson Collection stacks under their classification numbers. Unstarred magazines are located in the stacks.
A superlinear bound on the number of perfect matchings in cubic bridgeless graphs
Creators: name: Esperet, L.
name: Kardos, F.
name: Kral', D.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: Lovasz and Plummer conjectured in the 1970's that cubic bridgeless graphs have exponentially many perfect matchings. This conjecture has been verified for bipartite graphs by Voorhoeve in 1979, and for planar graphs by Chudnovsky and Seymour in 2008, but in general only linear bounds are known. In this paper, we provide the first superlinear bound in the general case.
description: 54 pages v2: a short (missing) proof of Lemma 10 was added
Additional file 6 of CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregulation in Huntington’s disease
Creators: name: Yu, Dahyun
name: Zarate, Nicole
name: White, Angel
name: Coates, De’jah
name: Tsai, Wei
name: Nanclares, Carmen
name: Cuccu, Francesco
name: Yue, Johnny S.
name: Brown, Taylor G.
name: Mansky, Rachel H.
name: Jiang, Kevin
name: Kim, Hyuck
name: Nichols-Meade, Tessa
name: Larson, Sarah N.
name: Gundry, Katherine
name: Zhang, Ying
name: Tomas-Zapico, Cristina
name: Lucas, Jose J.
name: Benneyworth, Michael
name: Öz, Gülin
name: Cvetanovic, Marija
name: Araque, Alfonso
name: Gomez-Pastor, Rocio
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 6. WGCNA modules genes assignment.
Trans-2-(2,5-dimethoxy-4-iodophenyl)cyclopropylamine and trans-2-(2,5-dimethoxy-4-bromophenyl)cyclopropylamine as potent agonists for the 5-HT 2 receptor family
Creators: name: Pigott, A.
name: Huang, X.-P.
name: McCorvy, J.D.
name: Roth, B.L.
name: Frescas, S.
name: Nichols, D.E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: A strategy to replace the ethylamine side chain of 2,5-dimethoxy-4- iodoamphetamine (DOI, 1a), and 2,5-dimethoxy-4-bromoamphetamine (DOB, 1b) with a cyclopropylamine moiety was successful in leading to compounds with high affinity at the 5-HT 2 family of receptors; and the more potent stereoisomer of the cyclopropane analogues had the expected (-)-(1R,2S)- configuration. Screening for affinity at various serotonin receptor subtypes, however, revealed that the cyclopropane congeners also had increased affinity at several sites in addition to the 5-HT 2A and 5-HT 2B receptors. Therefore, at appropriate doses - although (-)-4 and (-)-5 may be useful as tools to probe 5-HT 2 receptor function - one would need to be mindful that their selectivity for 5-HT 2A receptors is somewhat less than for DOI itself.
Mexican Americans in Texas: Notable Works, 1990-1996
Creators: name: Gutiérrez, Margo
Publisher: name: Benson Latin American Collection
Year: 1997
Subjects: Mexican Americans
Mexican Americans--Texas
Mexican American literature

description: This bibliography updates Biblionoticias No. 55, Mexican Americans in Texas: Notable Works, 1985-1989 and, with few exceptions, lists only published works that treat historical and social science topics relating to the Mexican American presence in Texas, from the Spanish colonial period to the present. Other titles that treat topics integral to the Mexican American cultural landscape are also included.
The Impact of Kaluza-Klein Fermions on Standard Model Fermion Couplings in a RS Model with Custodial Protection
Creators: name: Buras, Andrzej J.
name: Duling, Bjoern
name: Gori, Stefania
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We reconsider the impact of heavy vector-like fermions on the couplings of standard model (SM) quarks to the SM gauge bosons W and Z and to the SM Higgs boson H. Integrating out these fermions at tree level we derive general formulae that can be used in any model containing such particles. We apply these formulae to the case of the lightest Kaluza-Klein (KK) fermions in a Randall-Sundrum (RS) model with a custodial protection of flavour conserving $Zd_L^i d_L^i$ and flavour violating $Zd_L^i d_L^j$ couplings. We point out that in this model also the couplings of $Zu_R^i u_R^i$ and $Zu_R^i u_R^j$ are protected. In particular we demonstrate explicitly that this protection is not spoiled by the mixing of the SM quarks with the KK fermions, which is guaranteed by the underlying P_LR symmetry. We find that the impact of KK fermions on the Z-couplings, while not negligible, is significantly smaller than the one coming from the mixing of Z with the heavy KK gauge bosons Z_H and Z'.The situation is similar for the W couplings with the only exception of the tb coupling where the impact of KK fermions can in principle be larger than the effects that are induced by gauge boson mixing. We also show explicitly that at O(v^2/M_{KK}^2) the fermion-Higgs couplings of a Higgs placed on the infrared (IR) brane is not affected by the KK contributions up to strongly chirally suppressed contributions. The corrections to the CKM matrix, in particular the breakdown of its unitarity, are found to be small. We also investigate the right-handed couplings of W that are generated through the mixing with KK-fermions and introduce a 3x3 matrix that describes the pattern of flavour violation in these new interactions of the standard W.
description: 40 pages, 8 figures. Comments added, references added, typos corrected
Olanzapine induced weight gain in patients with cancer-related cachexia
Creators: name: Suthan Chanthawong
Publisher: name: Faculty of Pharmaceutical Sciences KKU MSU UBU
Year: 2012
Subjects: cancer-related cachexia, cancer-related anorexia, weight loss, nutritional status, olanzapine, corticosteroids

description: Isan Journal ofPharmaceutical Sciences, 8, 3, 1-9
title: Notices to Airmen - Domestic/International
Creators: name: Federal Aviation Administration
Publisher: name: United States Department of Transportation
publisherIdentifier: https://ror.org/02xfw2e90
publisherIdentifierScheme: ROR
Year: 1996
Subjects: classificationCode: https://trt.trb.org/term/91103
subject: Airspace (Law)
classificationCode: https://trt.trb.org/term/97475
subject: Reports
classificationCode: https://trt.trb.org/term/88021
subject: Air routes
classificationCode: https://trt.trb.org/term/92589
subject: Airports

description: References changes to the National Airspace System.
Latin American Art: Selected Sources
Creators: name: Gutiérrez-Witt, Laura
Publisher: name: Benson Latin American Collection
Year: 1998
Subjects: Latin American arts
indigenous art
Indian art--Central America

description: The increasingly visible presence of Latin American artists and their work on the global art scene has resulted in a vast increase in the number of publications and sources of information on Latin American art. A variety of institutions such as museums, galleries, and universities as well as commercial publishers and government cultural agencies in the United States, Latin America and Europe are sponsoring and distributing these materials. Necessarily the titles selected for this bibliography represent only those works which deal with Latin American art in general. Publications which deal with the history of art in one country or with only one artist are excluded due to their sheer volume. Latin American art is here defined to include all media: painting, architecture, sculpture, photography, drawing, printmaking, textiles, decorative art such as furniture and metalwork, and contemporary folk art. The titles are limited to works and artists of the sixteenth to twentieth centuries. Materials on pre-Columbian indigenous art are excluded, again because of their volume.
The calculation of expectations for classes of diffusion processes by Lie symmetry methods
Creators: name: Craddock, Mark
name: Lennox, Kelly A.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 35C05, 35K15, 60H99, 60G99 (Primary)

description: This paper uses Lie symmetry methods to calculate certain expectations for a large class of Itô diffusions. We show that if the problem has sufficient symmetry, then the problem of computing functionals of the form $E_x(e^{-λX_t-\int_0^tg(X_s) ds})$ can be reduced to evaluating a single integral of known functions. Given a drift $f$ we determine the functions $g$ for which the corresponding functional can be calculated by symmetry. Conversely, given $g$, we can determine precisely those drifts $f$ for which the transition density and the functional may be computed by symmetry. Many examples are presented to illustrate the method.
description: Published in at http://dx.doi.org/10.1214/08-AAP534 the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org)
The relationship between demographic and health factors, social support factors and antiretroviral adherence in HIV/AIDS patients, Um-Najaroen Province, Thailand
Creators: name: Nongnit Teerawatanasuk
Publisher: name: Faculty of Pharmaceutical Sciences KKU MSU UBU
Year: 2012
Subjects: antiretroviral (ARV) medications, ARV adherence, social support

description: Isan Journal ofPharmaceutical Sciences, 8, 3, 10-23
title: Spatiotemporal variability in northern shrimp (Pandalus borealis) life-history traits in Newfoundland and Labrador
Creators: name: Beita Jiménez, Andrés
Publisher: name: Memorial University of Newfoundland
Year: 2021

description: After the collapse of the groundfish stocks in the mid-90’s, northern shrimp has become one of the most economically important fisheries in Newfoundland and Labrador. However, the biomass has drastically decline since 2006 to reach similar low biomass levels as before the mid-90’s. Several reasons have been proposed for that decline including the recovery of predators, high fishing pressure, and changes in water temperature. Collapses and slow recoveries of fisheries have often been associated with life-history changes, but this has not yet been documented for northern shrimp in Newfoundland and Labrador. The goal of this thesis is to determine if there is variability in life-histories of northern shrimp and if it has contributed to the observed decline of the stock. I first used data from onboard observers and scientific surveys to estimate variation in size at sex transition from 1995 to 2016 and evaluate which factors are driving this variation. I found that trends in size at sex transition varied depending on the data source, but a general decline was observed. Fishing and temperature were identified as the main factors driving this decline, but the decline is more likely a consequence than a cause of reduction in abundance by fishing. I suggest that a compensatory response to reduced local abundance caused by fishing is the mechanism explaining observed variation in size at sex transition. In the second part of this thesis, I updated estimation of shrimp fecundity, which has not been done for 40 years. Then, I integrated new fecundity estimates with the size structure and size at sex transition information from the previous chapter to test if the variability in life history is affecting the estimation of indices of stock reproductive potential. I found that the number of eggs at size was 30% lower in 2018 than in 1978. However, the variability in size at sex transition and fecundity had little effect on the estimation of stock reproductive potential and did not cause major changes in the categorization of the stock status within the currently precautionary approach. I suggest that for this stock, the spawning stock biomass can be considered a good, parsimonious index to represent the reproductive potential.