cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Existence results for doubly nonlinear parabolic equations with two lower order terms and $L^1$-data
Creators: name: Benkirane, Abdelmoujib
name: Hadfi, Youssef El
name: Moumni, Mostafa El
Publisher: name: arXiv
Year: 2019
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35K55, 46E30, 74H20

description: We investigate the existence of a renormalized solution for a class of nonlinear parabolic equations with two lower order terms and $L^1$-data.
Cool stars in NGC 2547 and pre main sequence lithium depletion
Creators: name: Jeffries, R. D
name: Oliveira, J. M.
name: Navascues, D. Barrado y
name: Stauffer, J. R.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present the results of a spectroscopic survey of X-ray selected, low-mass candidate members of the young open cluster NGC 2547. Using a combination of photometry, spectroscopic indices and radial velocities we refine our candidate list and then use our spectroscopy to study the progression of lithium depletion in low-mass pre main sequence stars. We derive lithium abundances or upper limits for all our candidate members, which have effective temperatures in the range 5000>Teff>3200K, and compare these with predictions for lithium burning and depletion provided by a number of models and also with the lithium depletion seen in younger and older stars. We find that some models can reproduce the lithium abundance pattern of NGC 2547 if the cluster has an age of ~20-35Myr, which is also indicated by fits to low-mass isochrones in the Hertzsprung-Russell diagram. But the lack of significant further lithium depletion between NGC 2547 and older clusters argues for an age of at least 50Myr, more in keeping with the lack of lithium observed in even fainter NGC 2547 candidates. We show that reconciliation of these age estimates may require additions to the physics incorporated in current generations of pre main sequence models.
description: Accepted for publication in MNRAS (better version of Fig.1 available at http://www.astro.keele.ac.uk/~rdj/)
Parameters setting in the optimization problems from Reconciling periodic rhythms of large-scale biological networks by optimal control
Creators: name: Meichen Yuan
name: Junlin Qu
name: Weirong Hong
name: Li, Pu
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: 60114 Systems Biology
subject: FOS: Biological sciences
subject: Computational Biology

description: This material includes Table S1 which listed the parameters in the optimization problems of three case studies.
Scarification treatments in chepil seeds (Crotalaria longirostrata Hook. & Arn.) used to improve their germination
Creators: name: Rojas-García Adelaido, R.
name: Maldonado-Peralta María De Los Á.
name: Sánchez-Santillán Paulino
name: Ayala-Monter Marco, A.
name: Álvarez-Vázquez Perpetuo
name: Ramírez-Reynoso Omar
name: Rojas-García Adelaido, R.
name: Maldonado-Peralta María De Los Á.
name: Sánchez-Santillán Paulino
name: Ayala-Monter Marco, A.
name: Álvarez-Vázquez Perpetuo
name: Ramírez-Reynoso Omar
Publisher: name: Unknown
Year: 2021
Subjects: subject: Crop Production/Industries
subject: Farm Management
subject: Productivity Analysis
subject: legume
subject: emergence
subject: nutrition
subject: quality

description: Objective: The objective was to evaluate different scarification treatments to improve germination in chepil seeds (Crotalaria longirostrata Hook. & Arn.). Design/Methodology/Approach: The study was established in the School of Veterinary Medicine and Zootechnics N. 2 of the Universidad Autónoma de Guerrero. The chepil seeds were weighed and counted; 2 experiments were established through a CRD with 4 treatments of 4 repetitions each. Imbibition and germination were evaluated. The data were analyzed with the statistical software package SAS® 9.0.Results: The use of water at different temperatures and times presented positive results in imbibition and increased the germination percentages. The treatment with water at 100 °C until cooling reached a germination of 80%, and the control of 12.3%.Study Limitations/Implications: Chepil is a wild species that has seeds with physical dormancy, which is something that requires more research in order to accelerate and increase the germination percentages. Findings/Conclusions: The imbibition and germination was affected by the treatments applied. Chepil seeds presented physical or superficial dormancy that may be eliminated with the use of heat treatments; however, evaluations still need to be performed to accelerate and find a higher percentage of germination
Additional file 5 of Full spectrum flow cytometry-powered comprehensive analysis of PBMC as biomarkers for immunotherapy in NSCLC with EGFR-TKI resistance
Creators: name: Zhou, Juan
name: Chu, Xiangling
name: Zhao, Jing
name: Xie, Mengqing
name: Wu, Jing
name: Yu, Xin
name: Fang, Yujia
name: Li, Yazhou
name: Li, Xiyan
name: Su, Chunxia
Publisher: name: figshare
Year: 2023
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 5. Supplement figure 2. Heat map of expressions of immune checkpoint proteins in all patients.
Modal interferometric refractive index sensing in microstructured exposed core fibres
Creators: name: Maksymov, Ivan S.
name: Ebendorff-Heidepriem, Heike
name: Greentree, Andrew D.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Optics (physics.optics)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: Optical fibre-based sensors measuring refractive index shift in bodily fluids and tissues are versatile and accurate probes of physiological processes. Here, we suggest a refractive index sensor based on a microstructured exposed-core fibre (ECF). By considering a high refractive index coating of the exposed core, our modelling demonstrates the splitting of the guided mode into a surface sensing mode and a mode that is isolated from the surface. With the isolated mode acting as a reference arm, this two-mode one-fibre solution provides for robust interferometric sensing with a sensitivity of up to 60,000 rad/RIU-cm, which is suitable for sensing subtle physiological processes within hard-to-reach places inside living organisms, such as the spinal cord, ovarian tract and blood vessels.
Additional file 3 of Full spectrum flow cytometry-powered comprehensive analysis of PBMC as biomarkers for immunotherapy in NSCLC with EGFR-TKI resistance
Creators: name: Zhou, Juan
name: Chu, Xiangling
name: Zhao, Jing
name: Xie, Mengqing
name: Wu, Jing
name: Yu, Xin
name: Fang, Yujia
name: Li, Yazhou
name: Li, Xiyan
name: Su, Chunxia
Publisher: name: figshare
Year: 2023
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 3: Supplement table 2. Baseline characteristics of patients whose PBMC samples were collected (PBMC cohort) and comparison of PBMC cohort and the whole study population.
Point attractors in gastric cancer network from Reconciling periodic rhythms of large-scale biological networks by optimal control
Creators: name: Meichen Yuan
name: Junlin Qu
name: Weirong Hong
name: Li, Pu
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: 60114 Systems Biology
subject: FOS: Biological sciences
subject: Computational Biology

description: This material lists all the point attractors of gastric cancer network in Table S6.
Head-on/Near Head-on Collisions of Neutron Stars With a Realistic EOS
Creators: name: Evans, Edwin
name: Gopakumar, A.
name: Gressman, Philip
name: Iyer, Sai
name: Miller, Mark
name: Suen, Wai-Mo
name: Zhang, Hui-Min
Publisher: name: arXiv
Year: 2003
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: It has been conjectured that in head-on collisions of neutron stars (NSs), the merged object would not collapse promptly even if the total mass is higher than the maximum stable mass of a cold NS. In this paper, we show that the reverse is true: even if the total mass is {\it less} than the maximum stable mass, the merged object can collapse promptly. We demonstrate this for the case of NSs with a realistic equation of state (the Lattimer-Swesty EOS) in head-on {\it and} near head-on collisions. We propose a ``Prompt Collapse Conjecture'' for a generic NS EOS for head on and near head-on collisions.
description: 5 pages, 7 figures, submitted to Phy. Rev. D Rapid Comm
A Note on Duality Symmetry in Nonlinear Gauge Theories
Creators: name: Banerjee, Rabin
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: An intriguing connection, based on duality symmetry, between ordinary (commutative) Born-Infeld type theory and non-commutative Maxwell type theory, is pointed out. Both discrete as well as continuous duality transformations are considered and their implications for self duality condition and Legendre transformations are analysed.
description: 9 pages, LaTex
Extrinsic Curvature Embedding Diagrams
Creators: name: Lu, J. L.
name: Suen, W. -M.
Publisher: name: arXiv
Year: 2003
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Embedding diagrams have been used extensively to visualize the properties of curved space in Relativity. We introduce a new kind of embedding diagram based on the {\it extrinsic} curvature (instead of the intrinsic curvature). Such an extrinsic curvature embedding diagram, when used together with the usual kind of intrinsic curvature embedding diagram, carries the information of how a surface is {\it embedded} in the higher dimensional curved space. Simple examples are given to illustrate the idea.
description: 22 pages, 4 figures
Lorentz Symmetry Violation in QCD and the Frustration of Asymptotic Freedom
Creators: name: Drummond, I. T.
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We study the effect of Lorentz symmetry violation (LSV) on the behaviour at high energy of SU(N) gauge theory with quarks in the fundamental representation. The approach is similar to that for QED treated in a previous paper. In contrast to QED, standard Lorentz invariant QCD is asymptotically free. Our aim is to explore the structure of the renormalisation group at high energy and hence weak coupling without requiring the Lorentz symmetry breaking to be small. The simplest type of LSV leaves the theory invariant under a subgroup of the Lorentz group that preserves a (time-like) 4-vector. We examine this case in detail and find that asymptotic freedom is frustrated. That is, at sufficiently high energy the running coupling constant attains a minimum value before increasing again, while the LSV parameter increases without bound.
description: 20 pages, 8 figures, further references, minor text changes
Optimal results of chaotic system from Reconciling periodic rhythms of large-scale biological networks by optimal control
Creators: name: Meichen Yuan
name: Junlin Qu
name: Weirong Hong
name: Li, Pu
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: 60114 Systems Biology
subject: FOS: Biological sciences
subject: Computational Biology

description: This material shows the optimal control strategies for the transition from CYA to CHA, from CYA to POA, from POA to CYA, and from POA to CHA in chaotic system, and the different guess values of state variables and control variables in the optimization program for the state transition from CHA to POA as well.
title: Ανάλυση και τάσεις βαθμοημερών θέρμανσης και ψύξης στην Μεσόγειο
title: Analysis and trends of heating and cooling degree days in the Mediterranean region
Creators: name: Καζα Ιωαννα
Publisher: name: Technical University of Crete
Year: 2021

description: Η παγκόσμια κλιματική αλλαγή είναι ένα από τα πιο καίρια ζητήματα της σύγχρονης ζωής καθώς έχει σημαντικές επιπτώσεις σε πολλούς τομείς της ανθρώπινης ζωής. Ένας από αυτούς του τομείς είναι αυτός της ενέργειας. Η έρευνα αυτή επικεντρώνεται στην περιοχή της Μεσογείου, η οποία είναι ιδιαίτερα ευαίσθητη στις επιπτώσεις τις κλιματικής αλλαγής, και αποσκοπεί στην ανάλυση των τάσεων των ενεργειακών απαιτήσεων από το 1970 έως το 2100, μελετώντας όχι μόνο ιστορικά δεδομένα θερμοκρασίας αλλά και μελλοντικές προσομοιώσεις σύμφωνα με περιοχικά κλιματικά μοντέλα για επτά Μεσογειακές πόλεις διαφορετικούς μεγέθους/ πληθυσμού και γεωγραφικών χαρακτηριστικών. Οι βαθμοημέρες θέρμανσης (Heating Degree Days-HDD) και ψύξης (Cooling Degree Days-CDD) υπολογίστηκαν με σκοπό να προσδιοριστεί η τάση των ενεργειακών απαιτήσεων για θέρμανση και ψύξη. Η έρευνα αναδεικνύει μια στατιστικά σημαντική μείωση στις απαιτήσεις θέρμανσης σε όλες τις υπό μελέτη πόλεις, ενώ οι απαιτήσεις για ψύξη αυξάνονται με ρυθμό που φτάνει τους 64 βαθμούς ανά δεκαετία. Ταυτόχρονα, οι μελλοντικές προσομοιώσεις υποδεικνύουν μια αξιοσημείωτη αύξηση της διάρκειας της περιόδου που υπάρχουν ενεργειακές ανάγκες για ψύξη, με ρυθμό 5 ως 6 ημέρες/δεκαετία έως το τέλος του 21ου αιώνα, τη στιγμή που η διάρκεια της περιόδου που υπάρχουν ενεργειακές ανάγκες για θέρμανση παρουσιάζει αρνητική τάση με ρυθμό -4 ως -7 ημέρες/δεκαετία.
description: Global climate change is one of the most crucial issues of contemporary life as it has   important impacts on many aspects of human life, one of which is the energy sector. This research focuses on a very responsive to climate change area, the Mediterranean, and attempts to analyze the energy demand trends from 1970 through 2100, processing not only historical temperature records but future simulations from Regional Climate Models concerning seven Mediterranean cities of different sizes and geographical characteristics. Cooling degree days (CDD) and heating degree days (HDD) have been estimated in order to point out the trends in the amount of energy demands. The research has shown a statistically significant decrease in heating demands at all cities, while cooling demands are increasing at rates reaching up to 64 degrees per decade. On the other hand, future simulations suggest a remarkable expansion of the duration of the cooling demands period, at rates of 5 to 6 days per decade till the end of the century. At the same time, the duration of heating demands period presents a negative trend, at rates between -4 to -7 days per decade.
On the Kinematics of Galaxies and Associated QSO Absorption Systems
Creators: name: Kollmeier, Juna Ariele
Publisher: name: California Institute of Technology
Year: 2000
Subjects: Astrophysics
Physics

description: The methods available for studying galaxies directly, both individually and
as a class of objects, limit astronomers to certain regions of parameter space.
Since most observational techniques are rooted in the collection and analysis
of photons, there is always the danger of preferentially studying those
objects for which this information is more readily obtained. Such selection
effects can dramatically alter the physical picture one deduces. For example,
detailed studies of galaxies at optical wavelengths becomes extremely
difficult for objects located at distances corresponding to z approx. 1.5-3.
Furthermore, certain structures are too diffuse and/or faint to detect from
their emission signatures alone, even at relatively low redshifts. For example,
for material in the outer regions of the galaxy, where only small amounts
of star formation are occuring, it is very difficult to detect the presence of
the material from optical images alone despite the advent of ever bigger and
better instruments and telescopes. Fortunately, several methods exist that
allow astronomers to avoid these observational hurdles. One such method
is the use of quasar (QSO) absorption line systems.
Electromagnetic Response for High-Frequency Gravitational Waves in the GHz to THz Band
Creators: name: Li, Fang-Yu
name: Tang, Meng-Xi
name: Shi, Dong-Ping
Publisher: name: arXiv
Year: 2003
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We consider the electromagnetic (EM) response of a Gaussian beam passing through a static magnetic field to be the high-frequency gravitational waves (HFGW) as generated by several devices discussed at this conference. It is found that under the synchroresonance condition, the first-order perturbative EM power fluxes will contain a ''left circular wave'' and a ''right circular wave'' around the symmetrical axis of the Gaussian beam. However, the perturbative effects produced by the states of + polarization and \times polarization of the GW have a different physical behavior. For the HFGW of $ν_{g}=3GHz$, $h=10^{-30}$ (which corresponds to the power flux density $~ 10^{-6} W m^{-2}$) to $ν_{g}=1.3THz$, $ h=10^{-28}$ (which corresponds to the power flux density $~10^{3} W m^{-2}$) expected by the HFGW generators described at this conference, the corresponding perturbative photon fluxes passing through a surface region of $10^{-2} m^{2}$ would be expected to be $10^{3} s^{-1} - 10^{4} s^{-1}$. They are the orders of magnitude of the perturbative photon flux we estimated using typical laboratory parameters that could lead to the development of sensitive HFGW receivers. Moreover, we will also discuss the relative background noise problems and the possibility of displaying the HFGW. A laboratory test bed for juxtaposed HFGW generators and our detecting scheme is explored and discussed.
description: 19 pages, 3 figures
Primordial Magnetic Fields and Causality
Creators: name: Durrer, Ruth
name: Caprini, Chiara
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We discuss the implications of causality on a primordial magnetic field. We show that the residual field on large scales is much more suppressed than usually assumed and that a helical component is even more reduced. Due to this strong suppression, even maximal primordial fields generated at the electroweak phase transition can just marginally seed the fields in clusters, but they cannot leave any detectable imprint on the cosmic microwave background.
description: New version accepted for publication in JCAP, modified and improved, conclusions unchanged
Fidelity of Kane's Binary Gate
Creators: name: Dani, Keshav  Moreshwar
Publisher: name: California Institute of Technology
Year: 2000
Subjects: subject: Kane's Binary Gate
subject: Kane quantum computer
subject: Mathematics
subject: FOS: Mathematics
subject: quantum gate

description: The physics of information and computation has been a recognized discipline for several decades. This is not surprising. Information is, after all, encoded in the state of a physical system. Our abilities to compute and process information depend directly on the physics of the system. A computation is something that can be carried out on an actual physically realizable device.  Hence the study of information and computation is linked to the study of the underlying physical process. From the perspective of developing state-of-the-art computing technology, study of the principles of physics and material science is essential. From a more abstract and theoretical point of view, there have been noteworthy milestones in our understanding of how physics constrains our ability to use and manipulate information e.g. Landauer's Principle, Reversible Computation, Explanation of Maxwell's Daemon, etc.
Dopamine D2/3 receptor availability in alcohol use disorder and individuals at high risk: Towards a dimensional approach
Creators: name: Gleich, Tobias
name: Spitta, Gianna
name: Butler, Oisin
name: Zacharias, Kristin
name: Aydin, Semiha
name: Sebold, Miriam
name: Garbusow, Maria
name: Rapp, Michael
name: Schubert, Florian
name: Buchert, Ralph
name: Heinz, Andreas
name: Gallinat, Juergen
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: alcohol
subject: D2/3 receptors
subject: dependence
subject: dopamine
subject: high risk
subject: PET
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Alcohol use disorder (AUD) is the most common substance use disorder worldwide. Although dopamine-related findings were often observed in AUD, associated neurobiological mechanisms are still poorly understood. Therefore, in the present study, we investigate D2/3 receptor availability in healthy participants, participants at high risk (HR) to develop addiction (not diagnosed with AUD), and AUD patients in a detoxified stage, applying F-18-fallypride positron emission tomography (F-18-PET). Specifically, D2/3 receptor availability was investigated in (1) 19 low-risk (LR) controls, (2) 19 HR participants, and (3) 20 AUD patients after alcohol detoxification. Quality and severity of addiction were assessed with clinical questionnaires and (neuro)psychological tests. PET data were corrected for age of participants and smoking status. In the dorsal striatum, we observed significant reductions of D2/3 receptor availability in AUD patients compared with LR participants. Further, receptor availability in HR participants was observed to be intermediate between LR and AUD groups (linearly decreasing). Still, in direct comparison, no group difference was observed between LR and HR groups or between HR and AUD groups. Further, the score of the Alcohol Dependence Scale (ADS) was inversely correlated with D2/3 receptor availability in the combined sample. Thus, in line with a dimensional approach, striatal D2/3 receptor availability showed a linear decrease from LR participants to HR participants to AUD patients, which was paralleled by clinical measures. Our study shows that a core neurobiological feature in AUD seems to be detectable in an early, subclinical state, allowing more individualized alcohol prevention programs in the future.
A dynamic epistemic logic analysis of the equality negation task
Creators: name: Goubault, Eric
name: Lazic, Marijana
name: Ledent, Jeremy
name: Rajsbaum, Sergio
Publisher: name: arXiv
Year: 2019
Subjects: subject: Logic in Computer Science (cs.LO)
subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Computer and information sciences

description: In this paper we study the solvability of the equality negation task in a simple wait-free model where processes communicate by reading and writing shared variables or exchanging messages. In this task, two processes start with a private input value in the set {0,1,2}, and after communicating, each one must decide a binary output value, so that the outputs of the processes are the same if and only if the input values of the processes are different. This task is already known to be unsolvable; our goal here is to prove this result using the dynamic epistemic logic (DEL) approach introduced by Goubault, Ledent and Rajsbaum in GandALF 2018. We show that in fact, there is no epistemic logic formula that explains why the task is unsolvable. We fix this issue by extending the language of our DEL framework, which allows us to construct such a formula, and discuss its utility.
Culicoides leoni Barbosa 1952
Creators: name: Huerta
name: Rodríguez, Ana M.
name: William L. Grogan, Jr.
name: Ibáñez-Bernal, Sergio
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Ceratopogonidae
Culicoides
Culicoides leoni

description: Culicoides leoni Barbosa
 Culicoides leoni Barbosa, 1952: 17 (Ecuador).
 Culicoides (Oecacta) leoni: Wirth 1974: 33 (in New World catalog south of the USA; distribution).
 Discussion. The leoni species group is composed of 7 species, 6 of which inhabit the Neotropical region (Borkent and Spinelli 2007). The 7 th species, C. reevesi Wirth, is known in the Nearctic region from Arizona, California, New Mexico and Utah (Grogan et al. 2004; Borkent and Grogan 2009). The only species previously known from this group in Mexico is C. gabaldoni Ortiz, which is widely distributed in the Neotropical region (Borkent and Spinelli 2007).
 Culicoides leoni differs from other species in the leoni group by the following combination of characters: sensilla coeloconica on flagellomeres 1, 5-8; female wing length 0.63 mm; wing pattern with the caudal extension of the post-stigmatic pale spot not oblique in cell r 3 and usually connected to vein M 1; smaller pale spot on r-m crossvein; one pale spot in cell M 1 near base; and distal pale spot in anal cell abutting wing margin.
 This species was previously known from Ecuador (Borkent and Spinelli 2007), and Colombia (Spinelli et al. 2009). We provide the first records of C. leoni from Mexico.
 New records. Veracruz, Huatusco, Rancho Tenejapa, 7 May 1993, H. Huerta, colecta con aspirador, 2 females. New country record.
 Fluvialis Species Group
description: Published as part of Huerta, Rodríguez, Ana M., William L. Grogan, Jr. & Ibáñez-Bernal, Sergio, 2012, New records of biting midges of the genus Culicoides Latreille from Mexico (Diptera: Ceratopogonidae), pp. 1-20 in Insecta Mundi 2012 (211) on page 5, DOI: 10.5281/zenodo.5174160
Angiotensin II receptor blockade alleviates calcineurin inhibitor nephrotoxicity by restoring cyclooxygenase 2 expression in kidney cortex
Creators: name: Hu, Junda
name: Xu, Yan
name: Bachmann, Sebastian
name: Mutig, Kerim
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: calcineurin inhibitors
subject: cyclooxygenase 2
subject: macula densa
subject: nephrotoxicity
subject: renin-angiotensin system
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Aim: The use of calcineurin inhibitors such as cyclosporine A (CsA) for immunosuppression after solid organ transplantation is commonly limited by renal side effects. CsA-induced deterioration of glomerular filtration rate and sodium retention may be related to juxtaglomerular dysregulation as a result of suppressed cyclooxygenase 2 (COX-2) and stimulated renin biosynthesis. We tested whether CsA-induced COX-2 suppression is caused by hyperactive renin-angiotensin system (RAS) and whether RAS inhibition may alleviate the related side effects. Methods: Rats received CsA, the RAS inhibitor candesartan, or the COX-2 inhibitor celecoxib acutely (3 days) or chronically (3 weeks). Molecular pathways mediating effects of CsA and RAS on COX-2 were studied in cultured macula densa cells. Results: Pharmacological or siRNA-mediated calcineurin inhibition in cultured cells enhanced COX-2 expression via p38 mitogen-activated protein kinase and NF-kB signalling, whereas angiotensin II abolished these effects. Acute and chronic CsA administration to rats led to RAS activation along with reduced cortical COX-2 expression, creatinine clearance and fractional sodium excretion. Evaluation of major distal salt transporters, NKCC2 and NCC, showed increased levels of their activating phosphorylation upon CsA. Concomitant candesartan treatment blunted these effects acutely and completely normalized the COX-2 expression and renal functional parameters at long term. Celecoxib prevented the candesartan-induced improvements of creatinine clearance and sodium excretion. Conclusion: Suppression of juxtaglomerular COX-2 upon CsA results from RAS activation, which overrides the cell-autonomous, COX-2-stimulatory effects of calcineurin inhibition. Angiotensin II antagonism alleviates CsA nephrotoxicity via the COX-2-dependent normalization of creatinine clearance and sodium excretion.
Universal fluctuations in the bulk of Rayleigh-Bénard turbulence
Creators: name: Xie, Yi-Chao
name: Cheng, Bu-Ying-Chao
name: Hu, Yun-Bing
name: Xia, Ke-Qing
Publisher: name: arXiv
Year: 2019
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Geophysics (physics.geo-ph)
subject: FOS: Physical sciences

description: We present an investigation of the root-mean-square (rms) temperature $σ_T$ and the rms velocity $σ_w$ in the bulk of Rayleigh-Bénard turbulence, using new experimental data from the current study and experimental and numerical data from previous studies. We find that, once scaled by the convective temperature $θ_*$, the value of $σ_T$ at the cell centre is a constant, i.e. $σ_{T,c}/θ_* \approx 0.85$, over a wide range of the Rayleigh number ($10^{8}\leq Ra\leq 10^{15}$) and the Prandtl number ($0.7\leq Pr \leq 23.34$), and is independent of the surface topographies of the top and bottom plates of the convection cell. A constant close to unity suggests that $θ_*$ is a proper measure of the temperature fluctuation in the core region. On the other hand, $σ_{w,c}/w_*$, the vertical rms velocity at the cell centre scaled by the convective velocity $w_*$, shows a weak $Ra$-dependence ($\sim Ra^{0.07\pm0.02}$) over $10^8\leq Ra\leq 10^{10}$ at $Pr\sim4.3$ and is independent of plate topography. Similar to a previous finding by He \& Xia ({\it Phys. Rev. Lett.,} vol. 122, 2019, 014503), we find that the rms temperature profile $σ_T(z)/θ_*$ in the region of the mixing zone with a mean horizontal shear exhibits a power-law dependence on the distance $z$ from the plate, but now the universal profile applies to both smooth and rough surface topographies and over a wider range of $Ra$. The vertical rms velocity profile $σ_w(z)/w_*$ obey a logarithmic dependence on $z$. The study thus demonstrates that the typical scales for the temperature and the velocity are the convective temperature $θ_*$ and the the convective velocity $w_*$, respectively. Finally, we note that $θ_*$ may be utilised to study the flow regime transitions in the ultra-high-$Ra$-number turbulent convection.
description: 12 pages, 6 figures; Accepted for publication in the Journal of Fluid Mechanics
Efficacy and safety of topical delgocitinib in patients with chronic hand eczema: data from a randomized, double‐blind, vehicle‐controlled phase II a study
Creators: name: Worm, Margitta
name: Bauer, Andrea
name: Elsner, Peter
name: Mahler, Vera
name: Molin, Sonja
name: Nielsen, Thor S. S.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: Dermatologic Agents
subject: Double-Blind Method
subject: Eczema
subject: Ointments
subject: Treatment Outcome
subject: Pyrroles
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Management of chronic hand eczema (CHE) remains a challenge; effective topical treatment is limited to corticosteroids. Objectives: To assess the efficacy and safety of a novel, pan-Janus kinase inhibitor (delgocitinib) in patients with CHE. Methods: In this randomized, double-blind, phase IIa study, patients with CHE received delgocitinib ointment 30 mg g(-1) or vehicle ointment for 8 weeks. The primary end point was the proportion of patients achieving treatment success ['clear'/'almost clear' skin with ≥ 2-point improvement in the Physician's Global Assessment of disease severity (PGA)] at week 8. Secondary end points included Hand Eczema Severity Index (HECSI) score changes and the proportion of patients achieving treatment success on the Patient's Global Assessment of disease severity (PaGA). Results: Ninety-one patients were randomized. More patients receiving delgocitinib (46%) than vehicle (15%) [odds ratio 4 center dot 89, 95% confidence interval (CI) 1 center dot 49-16 center dot 09; P = 0 center dot 009] achieved treatment success (PGA). Adjusted mean HECSI score at week 8 was lower with delgocitinib (13 center dot 0) than with vehicle (25 center dot 8) (adjusted mean difference -12 center dot 88, 95% CI -21 center dot 47 to -4 center dot 30; P = 0 center dot 003). More patients receiving delgocitinib than vehicle achieved treatment success by PaGA, but this did not reach statistical significance. The incidence of adverse events was similar with delgocitinib and vehicle; none led to discontinuation of delgocitinib. Conclusions: Delgocitinib ointment was efficacious and well tolerated. As a plateau of efficacy was not observed, a longer treatment period may lead to increased efficacy. Further clinical studies are warranted to confirm these findings in patients with CHE.
Culicoides (Culicoides) neopulicaris Wirth 1955
Creators: name: Huerta
name: Rodríguez, Ana M.
name: William L. Grogan, Jr.
name: Ibáñez-Bernal, Sergio
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Ceratopogonidae
Culicoides
Culicoides neopulicaris

description: Culicoides (Culicoides) neopulicaris Wirth
 Culicoides neopulicaris Wirth, 1955a: 355 (Texas, USA).
 Culicoides (Culicoides) neopulicaris: Vargas 1960: 39 (in list of New World species in subgenus Culicoides).
 Discussion. The type locality of this species is Kerrville, Kerr County, Texas, but in his original description, Wirth (1955a) also identified four females from San Luis Potosí, Mexico that he did not designate as paratypes. Subsequently, Wirth and Blanton (1969) revised the pulicaris group in North America and identified additional specimens of C. neopulicaris from Chiapas, Morelos and Veracruz, Mexico and other material from Costa Rica and El Salvador. In their Nearctic wing atlas, Wirth et al. (1985) also listed this species from Louisiana, USA. We provide the first records from the states of Hidalgo, México and Yucatán, and additional records from Chiapas, Morelos and Veracruz.
 New records. Chiapas, Punta Macuilapa, 22 May 1964, 1 female (FSCA). Hidalgo, Tlanchinol, Carretera Tlanchinol-Apantlazol, 4 km, 11 March 1997, S. B. Salceda, J. Blackaller and G. A. Pérez, Malaise trap, 1 male (FSCA). México, Otumba, Coyotepec, 24 August-14 September 2007, Z. D. Hdez., Malaise trap, 1 female. Morelos, El Salto Falls, 17 June 1969, W. & D. Hasse, light trap, 44 females (FSCA). San Luis Potosí, El Salto Falls, 9 May 1964, 2 females; same data except April 1965, H. V. Weems, 1 female; same data except 21 April 1965, 1 female (FSCA). Veracruz, Actopan, Soyacuautla, 15 May 2008, Entomological brigade JS IV, CDC UV trap, 2 females; Emiliano Zapata, Chavarrillo, 14 May 2008, CDC UV trap, 3 females; same data except 3 September 2008, Entomological brigade JS IV, 2 females; Juchique de Ferrer, Los Arroyos, 5 February 2009, CDC trap, 1 female; same data except 18 February 2010, Entomological brigade JS IV, Malaise trap, 1 female; Atzalan, Plan de Arroyos, 19 May 2009, Entomological brigade JS IV, CDC trap, 2 females; Vega de Alatorre, Emilio Carranza, 8 September 2009, Entomological brigade JS IV, CDC trap, 1 female; Misantla, Paso Blanco, 23 February 2010, Entomological brigade JS IV, Malaise trap, 1 female. Yucatán, Celestun, near Ecoparaíso, 22-25 Jul 1998, H. Huerta & R. C. Pérez, Malaise trap, 1 male; Reserva Ría Lagartos, 8 July 1997, H. Huerta, S. P. Manrique & R. R. Paz, Malaise trap, 1 male.
description: Published as part of Huerta, Rodríguez, Ana M., William L. Grogan, Jr. & Ibáñez-Bernal, Sergio, 2012, New records of biting midges of the genus Culicoides Latreille from Mexico (Diptera: Ceratopogonidae), pp. 1-20 in Insecta Mundi 2012 (211) on page 7, DOI: 10.5281/zenodo.5174160
A new benzofuran from Artemisia halodendron Turcz. ex Bess.
Creators: name: Sun, Jinfeng
name: Zhou, Wei
name: Wei, Cheng-Xi
name: Zhang, Zhihong
name: Jin, Xuejun
name: Li, Gao
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: A new benzofuran, methyl (2S,2″S,3′E)-[2-(1″-acetoxypropan-2-yl)-2,3-dihydrobenzofuran-5-yl]acrylate (1), and 13 known compounds (2–14) were isolated from an ethanol extract of Artemisia halodendron Turcz. ex Bess. The chemical structures of these compounds were determined by 1D and 2D NMR (1H-1H COSY, HMBC, HMQC and NOESY) and HR-ESI-MS spectra, and results were compared with data from the literature. The effects of compounds 1–14 were measured on NF-κB activation, with compounds 2 and 3 exhibiting inhibitory activities against TNF-α-induced NF-κB reporter gene expression in HeLa cells from 10 to 100 μM.
Long-range order induced by random fields in two-dimensional O(n) models, and the Imry-Ma state
Creators: name: Berzin, A. A.
name: Morosov, A. I.
name: Sigov, A. S.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: The influence of defects of the "random local field" type with an anisotropic distribution of random fields on two-dimensional models with continuous symmetry of the vector order parameter is considered. In the case of weak anisotropy of random fields, with decreasing temperature there takes place a smooth transition from the paramagnetic phase with dynamic fluctuations of the order parameter to the Imry-Ma phase with static fluctuations caused by fluctuations of the random field of defects. In the case of strong anisotropy of random fields, defects lead to an effective decrease in the number of components of the order parameter and the appearance of a phase transition to an ordered state at finite temperature. It is shown that in the case of the defect-free two-dimensional X-Y model, the appearance of an arbitrarily weak anisotropy in the two-dimensional space of the order parameter completely eliminates the appearance of the Berezinsky-Kosterlitz-Thouless phase and gives rise to the phase with the long-range order.
description: 16 pages, 3 figures
Towards Principled Graph Transformers
Creators: name: Müller, Luis
name: Kusuma, Daniel
name: Bonet, Blai
name: Morris, Christopher
Publisher: name: RWTH Aachen University
Year: 2024

description: 38. Conference on Neural Information Processing Systems, NeurIPS 2024, Vancouver, Canada, 9 Dec 2024 - 15 Dec 2024; 28 Seiten (2024). doi:10.48550/arXiv.2401.10119
Analytical challenges of glycosaminoglycans at biological interfaces
Creators: name: Szekeres, Gergo Peter
name: Pagel, Kevin
name: Heiner, Zsuzsanna
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: Glycosaminoglycans
subject: Lipids
subject: Nonlinear spectroscopy
subject: Sum-frequency generation spectroscopy
subject: Interface/surface analysis
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

description: The analysis of glycosaminoglycans (GAGs) is a challenging task due to their high structural heterogeneity, which results in diverse GAG chains with similar chemical properties. Simultaneously, it is of high importance to understand their role and behavior in biological systems. It has been known for decades now that GAGs can interact with lipid molecules and thus contribute to the onset of atherosclerosis, but their interactions at and with biological interfaces, such as the cell membrane, are yet to be revealed. Here, analytical approaches that could yield important knowledge on the GAG-cell membrane interactions as well as the synthetic and analytical advances that make their study possible are discussed. Due to recent developments in laser technology, we particularly focus on nonlinear spectroscopic methods, especially vibrational sum-frequency generation spectroscopy, which has the potential to unravel the structural complexity of heterogeneous biological interfaces in contact with GAGs, in situ and in real time.
Chiral Perturbation on the Lightfront
Creators: name: Tang, Alfred
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: A new geometrical interpretation of chiral perturbation theory based on topological QCD is presented in picture format. This work is a written summary of a talk given at NAPP 2003 in Dubrovnik, Croatia.
description: 6 pages, 7 figures
Culicoides (Monoculicoides) occidentalis Wirth and Jones
Creators: name: Huerta
name: Rodríguez, Ana M.
name: William L. Grogan, Jr.
name: Ibáñez-Bernal, Sergio
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Ceratopogonidae
Culicoides
Culicoides occidentalis

description: Culicoides (Monoculicoides) occidentalis Wirth and Jones
 Culicoides variipennis occidentalis Wirth and Jones, 1957: 21 (California, USA).
 Culicoides occidentalis occidentalis: Downes 1978: 63 (change in status).
 Culicoides occidentalis: Holbrook et al. 2000: 71 (genetic analysis of variipennis complex; distribution).
 Culicoides (Monoculicoides) occidentalis: Borkent and Spinelli 2000: 36 (in catalog of the Americas south of the USA; distribution); Borkent and Grogan 2009: 15 (in Nearctic catalog; distribution).
 Discussion. This western Nearctic species occurs in southern British Columbia, Canada south to California, Nevada, New Mexico and Texas in the USA, and Mexico in Baja California and Puebla (Holbrook et al. 2000; Borkent and Grogan 2009). We provide an additional record from Baja California.
 New records. Baja California Sur, Loreto, 10 mi. S. Canipole, 28 August 1959, Radford & Werner, light trap, 3 females, 2 males.
description: Published as part of Huerta, Rodríguez, Ana M., William L. Grogan, Jr. & Ibáñez-Bernal, Sergio, 2012, New records of biting midges of the genus Culicoides Latreille from Mexico (Diptera: Ceratopogonidae), pp. 1-20 in Insecta Mundi 2012 (211) on page 13, DOI: 10.5281/zenodo.5174160
Nonlinear r-Modes in Neutron Stars: Instability of an unstable mode
Creators: name: Gressman, Philip
name: Lin, Lap-Ming
name: Suen, Wai-Mo
name: Stergioulas, N.
name: Friedman, John L.
Publisher: name: arXiv
Year: 2003
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We study the dynamical evolution of a large amplitude r-mode by numerical simulations. R-modes in neutron stars are unstable growing modes, driven by gravitational radiation reaction. In these simulations, r-modes of amplitude unity or above are destroyed by a catastrophic decay: A large amplitude r-mode gradually leaks energy into other fluid modes, which in turn act nonlinearly with the r-mode, leading to the onset of the rapid decay. As a result the r-mode suddenly breaks down into a differentially rotating configuration. The catastrophic decay does not appear to be related to shock waves at the star's surface. The limit it imposes on the r-mode amplitude is significantly smaller than that suggested by previous fully nonlinear numerical simulations.
description: Published in Phys. Rev. D Rapid Comm. 66, 041303(R) (2002)
Particle Creation in Anisotropically Expanding Universe
Creators: name: Suresh, P. K.
Publisher: name: arXiv
Year: 2003
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Using squeezed vacuum state formalism of quantum optics, an approximate solution to the semiclassical Einstein equation is obtained in Bianchi type-I universe. The phenomena of nonclassical particle creation is also examined in the anisotropic background cosmology.
description: 9 pages,LATEX, no figures
Tag2Pix: Line Art Colorization Using Text Tag With SECat and Changing Loss
Creators: name: Kim, Hyunsu
name: Jhoo, Ho Young
name: Park, Eunhyeok
name: Yoo, Sungjoo
Publisher: name: arXiv
Year: 2019
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Line art colorization is expensive and challenging to automate. A GAN approach is proposed, called Tag2Pix, of line art colorization which takes as input a grayscale line art and color tag information and produces a quality colored image. First, we present the Tag2Pix line art colorization dataset. A generator network is proposed which consists of convolutional layers to transform the input line art, a pre-trained semantic extraction network, and an encoder for input color information. The discriminator is based on an auxiliary classifier GAN to classify the tag information as well as genuineness. In addition, we propose a novel network structure called SECat, which makes the generator properly colorize even small features such as eyes, and also suggest a novel two-step training method where the generator and discriminator first learn the notion of object and shape and then, based on the learned notion, learn colorization, such as where and how to place which color. We present both quantitative and qualitative evaluations which prove the effectiveness of the proposed method.
description: Accepted to ICCV 2019
ROSAR: An Adversarial Re-Training Framework for Robust Side-Scan Sonar Object Detection
Creators: name: Aubard, Martin
name: Antal, László
name: Madureira, Ana
name: Teixeira, Luis F.
name: Ábrahám, Erika
Publisher: name: RWTH Aachen University
Year: 2024

description: 7 Seiten (2024). doi:10.48550/arXiv.2410.10554
Left Prefrontal Connectivity Links Subthalamic Stimulation with Depressive Symptoms
Creators: name: Irmen, Friederike
name: Horn, Andreas
name: Mosley, Philip
name: Perry, Alistair
name: Petry‐Schmelzer, Jan Niklas
name: Dafsari, Haidar S.
name: Barbe, Michael
name: Visser‐Vandewalle, Veerle
name: Schneider, Gerd‐Helge
name: Li, Ningfei
name: Kübler, Dorothee
name: Wenzel, Gregor
name: Kühn, Andrea A.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Parkinson Disease
subject: Prefrontal Cortex
subject: Subthalamic Nucleus
subject: Depression
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objective: Subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) not only stimulates focal target structures but also affects distributed brain networks. The impact this network modulation has on non-motor DBS effects is not well-characterized. By focusing on the affective domain, we systematically investigate the impact of electrode placement and associated structural connectivity on changes in depressive symptoms following STN-DBS, which have been reported to improve, worsen, or remain unchanged. Methods: Depressive symptoms before and after STN-DBS surgery were documented in 116 patients with PD from 3 DBS centers (Berlin, Queensland, and Cologne). Based on individual electrode reconstructions, the volumes of tissue activated (VTAs) were estimated and combined with normative connectome data to identify structural connections passing through VTAs. Berlin and Queensland cohorts formed a training and cross-validation dataset used to identify structural connectivity explaining change in depressive symptoms. The Cologne data served as the test-set for which depressive symptom change was predicted. Results: Structural connectivity was linked to depressive symptom change under STN-DBS. An optimal connectivity map trained on the Berlin cohort could predict changes in depressive symptoms in Queensland patients and vice versa. Furthermore, the joint training-set map predicted changes in depressive symptoms in the independent test-set. Worsening of depressive symptoms was associated with left prefrontal connectivity. Interpretation: Fibers connecting the electrode with left prefrontal areas were associated with worsening of depressive symptoms. Our results suggest that for the left STN-DBS lead, placement impacting fibers to left prefrontal areas should be avoided to maximize improvement of depressive symptoms. ANN NEUROL 2020;87:962-975