cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Analysis of the Basidiomycete Coprinopsis cinerea Reveals Conservation of the Core Meiotic Expression Program over Half a Billion Years of Evolution
Creators: name: Burns, Claire
name: Pukkila, Patricia J.
name: Lieb, Jason D.
name: Lilly, Walt W.
name: Zolan, Miriam E.
name: Hanlon, Sean E.
name: Gathman, Allen C.
name: Casselton, Lorna
name: Stajich, Jason E.
name: Wilke, Sarah K.
name: Savytskyy, Oleksandr P.
name: Rechtsteiner, Andreas
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Coprinopsis cinerea (also known as Coprinus cinereus) is a multicellular basidiomycete mushroom particularly suited to the study of meiosis due to its synchronous meiotic development and prolonged prophase. We examined the 15-hour meiotic transcriptional program of C. cinerea, encompassing time points prior to haploid nuclear fusion though tetrad formation, using a 70-mer oligonucleotide microarray. As with other organisms, a large proportion (∼20%) of genes are differentially regulated during this developmental process, with successive waves of transcription apparent in nine transcriptional clusters, including one enriched for meiotic functions. C. cinerea and the fungi Saccharomyces cerevisiae and Schizosaccharomyces pombe diverged ∼500–900 million years ago, permitting a comparison of transcriptional programs across a broad evolutionary time scale. Previous studies of S. cerevisiae and S. pombe compared genes that were induced upon entry into meiosis; inclusion of C. cinerea data indicates that meiotic genes are more conserved in their patterns of induction across species than genes not known to be meiotic. In addition, we found that meiotic genes are significantly more conserved in their transcript profiles than genes not known to be meiotic, which indicates a remarkable conservation of the meiotic process across evolutionarily distant organisms. Overall, meiotic function genes are more conserved in both induction and transcript profile than genes not known to be meiotic. However, of 50 meiotic function genes that were co-induced in all three species, 41 transcript profiles were well-correlated in at least two of the three species, but only a single gene (rad50) exhibited coordinated induction and well-correlated transcript profiles in all three species, indicating that co-induction does not necessarily predict correlated expression or vice versa. Differences may reflect differences in meiotic mechanisms or new roles for paralogs. Similarities in induction, transcript profiles, or both, should contribute to gene discovery for orthologs without currently characterized meiotic roles.
Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk
Creators: name: Liu, Yan
name: Sanoff, Hanna K.
name: Wang, Zefeng
name: Jeck, William R.
name: Burd, Christin E.
name: Sharpless, Norman E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Human genome-wide association studies have linked single nucleotide polymorphisms (SNPs) on chromosome 9p21.3 near the INK4/ARF (CDKN2a/b) locus with susceptibility to atherosclerotic vascular disease (ASVD). Although this locus encodes three well-characterized tumor suppressors, p16INK4a, p15INK4b, and ARF, the SNPs most strongly associated with ASVD are ∼120 kb from the nearest coding gene within a long non-coding RNA (ncRNA) known as ANRIL (CDKN2BAS). While individuals homozygous for the atherosclerotic risk allele show decreased expression of ANRIL and the coding INK4/ARF transcripts, the mechanism by which such distant genetic variants influence INK4/ARF expression is unknown. Here, using rapid amplification of cDNA ends (RACE) and analysis of next-generation RNA sequencing datasets, we determined the structure and abundance of multiple ANRIL species. Each of these species was present at very low copy numbers in primary and cultured cells; however, only the expression of ANRIL isoforms containing exons proximal to the INK4/ARF locus correlated with the ASVD risk alleles. Surprisingly, RACE also identified transcripts containing non-colinear ANRIL exonic sequences, whose expression also correlated with genotype and INK4/ARF expression. These non-polyadenylated RNAs resisted RNAse R digestion and could be PCR amplified using outward-facing primers, suggesting they represent circular RNA structures that could arise from by-products of mRNA splicing. Next-generation DNA sequencing and splice prediction algorithms identified polymorphisms within the ASVD risk interval that may regulate ANRIL splicing and circular ANRIL (cANRIL) production. These results identify novel circular RNA products emanating from the ANRIL locus and suggest causal variants at 9p21.3 regulate INK4/ARF expression and ASVD risk by modulating ANRIL expression and/or structure.
Problem Classification for Tailored Helpdesk Auto-Replies
Creators: name: Nicholls, Reece
name: Fellows, Ryan
name: Battle, Steve
name: Ihshaish, Hisham
Publisher: name: arXiv
Year: 2022
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: IT helpdesks are charged with the task of responding quickly to user queries. To give the user confidence that their query matters, the helpdesk will auto-reply to the user with confirmation that their query has been received and logged. This auto-reply may include generic `boiler-plate' text that addresses common problems of the day, with relevant information and links. The approach explored here is to tailor the content of the auto-reply to the user's problem, so as to increase the relevance of the information included. Problem classification is achieved by training a neural network on a suitable corpus of IT helpdesk email data. While this is no substitute for follow-up by helpdesk agents, the aim is that this system will provide a practical stop-gap.
description: Artificial Neural Networks and Machine Learning, ICANN 2022, 31st International Conference on Artificial Neural Networks, Bristol, UK, September, 2022, Proceedings; Part IV (445 454)
Genome-Wide Meta-Analysis for Serum Calcium Identifies Significantly Associated SNPs near the Calcium-Sensing Receptor (CASR) Gene
Creators: name: Mooser, Vincent
name: Gudbjartsson, Daniel F.
name: DeSilva, Ranil
name: Stefansson, Kari
name: Waeber, Gérard
name: Milaneschi, Yuri
name: Singleton, Andrew B.
name: Hernandez, Dena G.
name: Bandinelli, Stefania
name: Elliott, Paul
name: Sigurdsson, Gunnar
name: Li, Yun
name: Zhang, Weihua
name: Kooner, Jaspal S.
name: Guralnik, Jack M.
name: Marek, Diana
name: Chambers, John
name: DiIorio, Angelo
name: Ferrucci, Luigi
name: Holm, Hilma
name: Waterworth, Dawn
name: Kapur, Karen
name: Beckmann, Noam D.
name: Tanaka, Toshiko
name: Eyjolfsson, Gudmundur I.
name: Thorsteinsdottir, Unnur
name: Bjornsdottir, Unnur S.
name: Johnson, Toby
name: Sehmi, Joban
name: Styrkarsdottir, Unnur
name: Kutalik, Zoltán
name: Scott, James
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Calcium has a pivotal role in biological functions, and serum calcium levels have been associated with numerous disorders of bone and mineral metabolism, as well as with cardiovascular mortality. Here we report results from a genome-wide association study of serum calcium, integrating data from four independent cohorts including a total of 12,865 individuals of European and Indian Asian descent. Our meta-analysis shows that serum calcium is associated with SNPs in or near the calcium-sensing receptor (CASR) gene on 3q13. The top hit with a p-value of 6.3×10-37 is rs1801725, a missense variant, explaining 1.26% of the variance in serum calcium. This SNP had the strongest association in individuals of European descent, while for individuals of Indian Asian descent the top hit was rs17251221 (p = 1.1×10-21), a SNP in strong linkage disequilibrium with rs1801725. The strongest locus in CASR was shown to replicate in an independent Icelandic cohort of 4,126 individuals (p = 1.02×10-4). This genome-wide meta-analysis shows that common CASR variants modulate serum calcium levels in the adult general population, which confirms previous results in some candidate gene studies of the CASR locus. This study highlights the key role of CASR in calcium regulation.
Parameterizing the semantics of fuzzy attribute implications by systems of isotone Galois connections
Creators: name: Vychodil, Vilem
Publisher: name: arXiv
Year: 2014
Subjects: subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences
subject: I.2.3; I.2.4
subject: 03B52, 68P20, 06A15

description: We study the semantics of fuzzy if-then rules called fuzzy attribute implications parameterized by systems of isotone Galois connections. The rules express dependencies between fuzzy attributes in object-attribute incidence data. The proposed parameterizations are general and include as special cases the parameterizations by linguistic hedges used in earlier approaches. We formalize the general parameterizations, propose bivalent and graded notions of semantic entailment of fuzzy attribute implications, show their characterization in terms of least models and complete axiomatization, and provide characterization of bases of fuzzy attribute implications derived from data.
Sant’Agabio Resiliente: inclusion and solidarity for the urban environment
Creators: name: Carli, Paolo
name: Fabris, Luca
name: Granello, Guido
Publisher: name: TECHNE - Journal of Technology for Architecture and Environment
Year: 2018

description: This paper presents the work of the Politecnico di Milano for the “Together It Can Be Done: Sant’Agabio Resiliente” project funded by the Cariplo foundation (2016). Inspired by the principles of the Transition Towns movement, the study intervenes in a multiethnic neighborhood of the Municipality of Novara with innovative actions that enhance the quality of urban environment. The original contribution of the project was the activation of the resilience of a community that is in the process of rehabilitation with goals of solidarity, inclusiveness, participation, and autonomy for the future. The strategies adopted have allowed the involvement of associations in activities relevant to environmental resilience and the facilitation of concrete actions able to generate empathy.
description: TECHNE - Journal of Technology for Architecture and Environment, TECHNE 15 (2018): Architectural resilience
Enhancement of quantum correlations between two particles under decoherence in finite temperature environment
Creators: name: Doustimotlagh, Nasibollah
name: Wang, Shuhao
name: You, Chenglong
name: Long, Gui-Lu
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Enhancing the quantum correlations in realistic quantum systems interacting with the environment of finite temperature is an important subject in quantum information processing. In this paper, we use weak measurement and measurement reversal to enhance the quantum correlations in a quantum system consisting of two particles. The transitions of the quantum correlations measured by the local quantum uncertainty of qubit-qubit and qutrit-qutrit quantum systems under generalized amplitude damping channels are investigated. We show that, after the weak measurement and measurement reversal, the joint system shows more robustness against decoherence.
description: 5 pages, 5 figures
Theoretical comparison of real-time feedback-driven single-particle tracking techniques
Creators: name: van Heerden, Bertus
name: Krüger, Tjaart P. J.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Chemical Physics (physics.chem-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Real-time feedback-driven single-particle tracking is a technique that uses feedback control to enable single-molecule spectroscopy of freely diffusing particles in native or near-native environments. A number of different RT-FD-SPT approaches exist, and comparisons between methods based on experimental results are of limited use due to differences in samples and setups. In this study, we used statistical calculations and dynamical simulations to directly compare the performance of different methods. The methods considered were the orbital method, the Knight`s Tour (grid scan) method and MINFLUX, and we considered both fluorescence-based and interferometric scattering (iSCAT) approaches. There is a fundamental trade-off between precision and speed, with the Knight`s Tour method being able to track the fastest diffusion but with low precision, and MINFLUX being the most precise but only tracking slow diffusion. To compare iSCAT and fluorescence, different biological samples were considered, including labeled and intrinsically fluorescent samples. The success of iSCAT as compared to fluorescence is strongly dependent on the particle size and the density and photophysical properties of the fluorescent particles. Using a wavelength for iSCAT that is negligibly absorbed by the tracked particle allows an increased illumination intensity, which results in iSCAT providing better tracking for most samples. This work highlights the fundamental aspects of performance in RT-FD-SPT and should assist with the selection of an appropriate method for a particular application. The approach used can easily be extended to other RT-FD-SPT methods.
description: 29 Pages, 8 figures. Replaced submitted manuscript with accepted manuscript. This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. The published article may be found at https://doi.org/10.1063/5.0096729
Performance and Clique Analysis of the Iranian Universities and Research Institutions Informetrics: 10 Years Study
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2016

description: Objective: The current research aims to investigate the co-authorship network of Iranian universities and research institutions in informetrics research during 2002-2012 using social network analysis. Methodology: Using scientometric approach and social network analysis measures, this paper studies co-authorship network of Iranian universities and research institutions in informetrics research. The research population includes 779 articles published in both English and Persian and indexed in 4th edition of scientometrics bibliography during 2002-2012. First, the co-authorship matrix of institutions was drawn by using excel software second, the UCINET and VOSviewer software were utilized for data analysis. Findings: Results revealed that institutions like Tehran University, Tehran University of Medical Sciences, Islamic Azad University, Tarbiat Modares University, Shahed University, Shahid Chamran University of Aheaz, Regional Information Center for Science and Technology, and National Research Institute for Science Policy play the most important and central roles in the informetrics collaboration network based on productivity, centrality, and collaboration measures. The highest number of co-authored papers in this network have been written by the following pairs of institutions: “Tarbiat Modares University- Shahed University”, “Payame Noor University- Regional Information Center for Science and Technology”, and “Shahed University- National Research Institute for Science Policy” respectively. Conclusion: Results of the clique analysis showed that this network is made of 12 cliques with at least 5 institutions. Tehran University and Islamic Azad University were in the highest number of subgroups of the network with 7 cliques.
The Caenorhabditis elegans Homolog of Gen1/Yen1 Resolvases Links DNA Damage Signaling to DNA Double-Strand Break Repair
Creators: name: Freeman, Alasdair
name: Gartner, Anton
name: Lilley, David M. J.
name: Hall, Julie
name: Bailly, Aymeric P.
name: Déclais, Anne-Cécile
name: Ahmed, Shawn
name: Alpi, Arno
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: DNA double-strand breaks (DSBs) can be repaired by homologous recombination (HR), which can involve Holliday junction (HJ) intermediates that are ultimately resolved by nucleolytic enzymes. An N-terminal fragment of human GEN1 has recently been shown to act as a Holliday junction resolvase, but little is known about the role of GEN-1 in vivo. Holliday junction resolution signifies the completion of DNA repair, a step that may be coupled to signaling proteins that regulate cell cycle progression in response to DNA damage. Using forward genetic approaches, we identified a Caenorhabditis elegans dual function DNA double-strand break repair and DNA damage signaling protein orthologous to the human GEN1 Holliday junction resolving enzyme. GEN-1 has biochemical activities related to the human enzyme and facilitates repair of DNA double-strand breaks, but is not essential for DNA double-strand break repair during meiotic recombination. Mutational analysis reveals that the DNA damage-signaling function of GEN-1 is separable from its role in DNA repair. GEN-1 promotes germ cell cycle arrest and apoptosis via a pathway that acts in parallel to the canonical DNA damage response pathway mediated by RPA loading, CHK1 activation, and CEP-1/p53–mediated apoptosis induction. Furthermore, GEN-1 acts redundantly with the 9-1-1 complex to ensure genome stability. Our study suggests that GEN-1 might act as a dual function Holliday junction resolvase that may coordinate DNA damage signaling with a late step in DNA double-strand break repair.
Identifying and weighting of key performance indicators of knowledge management2.0 in organizations
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2016

description: Main purpose of this research is identifying and weighting of key performance indicators of knowledge management2.0 in organizations. According to widespread permeation of technology, especially social media in different organizational dimensions and functional view to this phenomenon in knowledge management, performance measurement of this kind of media in order to meet organizational goals seems necessary. KM2.0 key performance indicators in this article has been identified and weighted through Delphi methodology, via questionnaire in three rounds. KM2.0 KPIs which are identified and weighted in this article are applicable in organizations that are eager to implement KM2.0 initiative and they can measure the performance of KM2.0 activities therefore this research is applicable in goal oriented approach. According to the results, KM2.0 participation process consists of 3 stages and 8 steps as mentioned below: First stage which is presence, consists of 3 steps which are registration, visit and download. Second stage which is feedback consists of 3 steps which are conversation, applause and amplification. Finally, third stage which is creation consists of 2 steps which are codification and personalization. Ultimate contribution of this research is identifying and weighting KPIs of KM2.0 in conceptual framework of KM2.0. Based on developing a conceptual framework and participation process in KM2.0 and listing related KPIs as an applicable solution in order to measure and improve the performance of organizational social media, this research has unique innovation among related and other articles.
An Investigation of Knowledge Management Processes in the Websites of Digital Library of Iran
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2016

description: The purpose of this study is to identify Knowledge Management Processes in Iranian digital library websites. This is an applied research. Statistical population of the study consists of 11 digital library websites. In order to collect data, a checklist was prepared by the researcher and then data were analyzed by (through) descriptive and inferential statistics. The findings showed that the survey of knowledge management in digital libraries is lower moderate. While the studies components scored, process identification 1.79, process acquisition 1.67, development 1.34, sharing and distribution 0.82, utilization 2.06 and retention 1.8 were lower moderate. This study which aimed to survey the Knowledge Management Processes in Iranian digital library websites is of the first once in attending Knowledge Management Processes in Iran and it can have an important role in introducing Knowledge Management Processes to digital libraries softwares developers.
The role of Nature-Based Solutions in architectural and urban design
Creators: name: Mussinelli, Elena
name: Tartaglia, Andrea
name: Bisogni, Luca
name: Malcevschi, Sergio
Publisher: name: TECHNE - Journal of Technology for Architecture and Environment
Year: 2018

description: In 2015 the European Commission published the report Towards an EU Research and Innovation policy agenda for Nature-Based Solutions and Re-Naturing Cities. The document standardised the many research and innovation opportunities linked to the new designing, realisation and management procedures which utilise the natural component as an important tool to support urban regeneration processes capable of building resilience and developing a green economy. This essay analyses critically the new technical elements of architectural and urban design that make use of nature-based solutions. The aim is to examine their actual capability to generate/regenerate ecosystem services and circular economy processes at various levels.
description: TECHNE - Journal of Technology for Architecture and Environment, TECHNE 15 (2018): Architectural resilience
The CYCLIN-A CYCA1;2/TAM Is Required for the Meiosis I to Meiosis II Transition and Cooperates with OSD1 for the Prophase to First Meiotic Division Transition
Creators: name: Girard, Chloé
name: Mercier, Raphael
name: Horlow, Christine
name: Cromer, Laurence
name: Jolivet, Sylvie
name: d'Erfurth, Isabelle
name: Copenhaver, Gregory P.
name: Sun, Yujin
name: Berchowitz, Luke E.
name: To, Jennifer P. C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Meiosis halves the chromosome number because its two divisions follow a single round of DNA replication. This process involves two cell transitions, the transition from prophase to the first meiotic division (meiosis I) and the unique meiosis I to meiosis II transition. We show here that the A-type cyclin CYCA1;2/TAM plays a major role in both transitions in Arabidopsis. A series of tam mutants failed to enter meiosis II and thus produced diploid spores and functional diploid gametes. These diploid gametes had a recombined genotype produced through the single meiosis I division. In addition, by combining the tam-2 mutation with AtSpo11-1 and Atrec8, we obtained plants producing diploid gametes through a mitotic-like division that were genetically identical to their parents. Thus tam alleles displayed phenotypes very similar to that of the previously described osd1 mutant. Combining tam and osd1 mutations leads to a failure in the prophase to meiosis I transition during male meiosis and to the production of tetraploid spores and gametes. This suggests that TAM and OSD1 are involved in the control of both meiotic transitions.
LCA environmental impacts of Europe’s housing stock and prevention scenarios
Creators: name: Lavagna, Monica
name: Sala, Serenella
Publisher: name: TECHNE - Journal of Technology for Architecture and Environment
Year: 2018

description: Resilience is defined as the capacity of a system to cope with impacts by minimising their effects (through adaptation and mitigation). In practice, upstream measures on the causes, in terms of reducing the emissions or using resource more efficiently, should constitute the main action strategy for reducing the environmental impacts. The article describes the results of a research aiming at quantifing the average environmental impacts associated with the current housing stock in Europe through the construction of statistically-based representative models and the application of the Life Cycle Assessment (LCA) method. Knowledge of the characteristics and the environmental performances of the building stock – particularly the residential building stock – is of fundamental importance to establish effective policies and priority actions for the prevention of impacts and the strengthening of the resilience.
description: TECHNE - Journal of Technology for Architecture and Environment, TECHNE 15 (2018): Architectural resilience
The Histone H3K36 Methyltransferase MES-4 Acts Epigenetically to Transmit the Memory of Germline Gene Expression to Progeny
Creators: name: Egelhofer, Thea A.
name: Kimura, Hiroshi
name: Lieb, Jason D.
name: Wang, Wenchao
name: Rechtsteiner, Andreas
name: Phippen, Taryn M.
name: Ercan, Sevinc
name: Strome, Susan
name: Takasaki, Teruaki
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Methylation of histone H3K36 in higher eukaryotes is mediated by multiple methyltransferases. Set2-related H3K36 methyltransferases are targeted to genes by association with RNA Polymerase II and are involved in preventing aberrant transcription initiation within the body of genes. The targeting and roles of the NSD family of mammalian H3K36 methyltransferases, known to be involved in human developmental disorders and oncogenesis, are not known. We used genome-wide chromatin immunoprecipitation (ChIP) to investigate the targeting and roles of the Caenorhabditis elegans NSD homolog MES-4, which is maternally provided to progeny and is required for the survival of nascent germ cells. ChIP analysis in early C. elegans embryos revealed that, consistent with immunostaining results, MES-4 binding sites are concentrated on the autosomes and the leftmost ∼2% (300 kb) of the X chromosome. MES-4 overlies the coding regions of approximately 5,000 genes, with a modest elevation in the 5′ regions of gene bodies. Although MES-4 is generally found over Pol II-bound genes, analysis of gene sets with different temporal-spatial patterns of expression revealed that Pol II association with genes is neither necessary nor sufficient to recruit MES-4. In early embryos, MES-4 associates with genes that were previously expressed in the maternal germ line, an interaction that does not require continued association of Pol II with those loci. Conversely, Pol II association with genes newly expressed in embryos does not lead to recruitment of MES-4 to those genes. These and other findings suggest that MES-4, and perhaps the related mammalian NSD proteins, provide an epigenetic function for H3K36 methylation that is novel and likely to be unrelated to ongoing transcription. We propose that MES-4 transmits the memory of gene expression in the parental germ line to offspring and that this memory role is critical for the PGCs to execute a proper germline program.
MoNGUE project for the sustainable development of Mozambique
Creators: name: Baiardi, Liala
name: Puglisi, Valentina
Publisher: name: TECHNE - Journal of Technology for Architecture and Environment
Year: 2018

description: The project fits into the context of management of climatic threats and natural disasters in developing countries. It is example Mozambique, seat of deepening of research, where the negative effects of climatic threats are amplified by the low level of resilience of the built environment. For the progress of the country and the development of the territory. The ability of resilience, adaptability and transformability play a fundamental role in the new forecasting processes and project aimed at the improvement of systems of settlements. The article describes the application testing of a methodology of investigation repeatable in similar contexts, time to outline a cognitive basis to trace possible actions for improvement in respect of the identity of the place.
description: TECHNE - Journal of Technology for Architecture and Environment, TECHNE 15 (2018): Architectural resilience
Scenario’s evaluation by design. A “scenarios approach” to resilience
Creators: name: Di Giulio, Roberto
name: Emanueli, Luca
name: Lobosco, Gianni
Publisher: name: TECHNE - Journal of Technology for Architecture and Environment
Year: 2018

description: This contribution describes opportunities and advantages related to the use of the “scenarios” approach in the design of resilient anthropic systems. A methodology that aims to support, from the early stages of the decision-making process, strategical choices concerning complex works and areas by duration, size and interactions with the environment. A model that, given the current situation of extreme economic and environmental uncertainty, could represent an effective collaboration protocol between decision makers, designers and experts of various disciplines, especially in the development of large-scale infrastructure systems and human settlements that involve extended planning and implementation timings, requiring a high degree of programmed adaptability.
description: TECHNE - Journal of Technology for Architecture and Environment, TECHNE 15 (2018): Architectural resilience
A Conserved PHD Finger Protein and Endogenous RNAi Modulate Insulin Signaling in Caenorhabditis elegans
Creators: name: Mansisidor, Andres R.
name: Chavez, Violeta
name: Tan, Man-Wah
name: Grishok, Alla
name: Kennedy, Lisa M.
name: Kawli, Trupti
name: Lieb, Jason D.
name: Cecere, Germano
name: Jensen, Morten B.
name: Hoersch, Sebastian
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Insulin signaling has a profound effect on longevity and the oxidative stress resistance of animals. Inhibition of insulin signaling results in the activation of DAF-16/FOXO and SKN-1/Nrf transcription factors and increased animal fitness. By studying the biological functions of the endogenous RNA interference factor RDE-4 and conserved PHD zinc finger protein ZFP-1 (AF10), which regulate overlapping sets of genes in Caenorhabditis elegans, we identified an important role for these factors in the negative modulation of transcription of the insulin/PI3 signaling-dependent kinase PDK-1. Consistently, increased expression of pdk-1 in zfp-1 and rde-4 mutants contributed to their reduced lifespan and sensitivity to oxidative stress and pathogens due to the reduction in the expression of DAF-16 and SKN-1 targets. We found that the function of ZFP-1 in modulating pdk-1 transcription was important for the extended lifespan of the age-1(hx546) reduction-of-function PI3 kinase mutant, since the lifespan of the age-1; zfp-1 double mutant strain was significantly shorter compared to age-1(hx546). We further demonstrate that overexpression of ZFP-1 caused an increased resistance to oxidative stress in a DAF-16–dependent manner. Our findings suggest that epigenetic regulation of key upstream signaling components in signal transduction pathways through chromatin and RNAi may have a large impact on the outcome of signaling and expression of numerous downstream genes.
A rating system for building resilience
Creators: name: Re Cecconi, Fulvio
name: Moretti, Nicola
name: Maltese, Sebastiano
name: Dejaco, Mario
name: Kamara, John
name: Heidrich, Oliver
Publisher: name: TECHNE - Journal of Technology for Architecture and Environment
Year: 2018

description: Measuring and rating resilience of assets is a key enabler for asset and portfolio management. This paper presents a resilience rating system for buildings by utilising a Building Information Modelling approach. The assessment is carried out through a calculation following the Analytical Hierarchy Process. This methodology can be applied to different types of buildings, without a loss of precision or reliability. This resilience rating forms an integral part of more comprehensive array of Key Performance Indicators frameworks for asset and portfolio management, and therefore can significantly influence strategic investment choices for designers, engineers and building owners.
description: TECHNE - Journal of Technology for Architecture and Environment, TECHNE 15 (2018): Architectural resilience
Adaptive exoskeleton systems for the resilience of the built environment
Creators: name: Bellini, Oscar
name: Marini, Alessandra
name: Passoni, Chiara
Publisher: name: TECHNE - Journal of Technology for Architecture and Environment
Year: 2018

description: The concept of resilience can be applied to postwar buildings, which are increasingly exposed to seismic events. Today this threat can be dealt with through preventive practices, based on the use of adaptive exoskeletons: prosthetic systems that identify a field of experimentation marked by an undoubted social, environmental and economic value. This technique is based on a design that simultaneously allows seismic upgrade, energy retrofit, plant-engineering adjustment and the remodelage of those structurally, aesthetically and functionally obsolete and highly vulnerable residential buildings, on which resilience can activate targeted policies aimed at the preservation of human life, environmental sustainability and the rational use of the scarce economic resources available.
description: TECHNE - Journal of Technology for Architecture and Environment, TECHNE 15 (2018): Architectural resilience
A Framework for Creation & Diffusion of Knowledge for Knowledge Management in Enterprise 2.0
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2016

description: Certainly in modern organizations knowledge & its management is basic & one of the most important issues. Powerful organizations in knowledge management are pioneer & always are in the first line of competition. It is obvious that rate & quality in creation, dissemination & use of knowledge are competitive advantage for organizations. As regards modern organizations use technology & new tools, enterprise 2.0 is known as a good organization in use of web 2.0 tools & high cooperation of staff. Passing of Enterprise 1.0 to Enterprise 2.0 & try for creation &diffusion of knowledge in Enterprise 2.0 have its own problems that without knowing of them & a certain framework, the probability of success is very low. This Research presents the framework of creation & diffusion of knowledge in Enterprise 2.0 according of library resources & presents learning 2.0, communications 2.0, generated content & collaboration 2.0 as 4 stages of creation &diffusion of knowledge in Enterprise 2.0. Then we investigate any of stages according of human, knowledge & technology. Also this research emphasizes that for creation &diffusion of knowledge in Enterprise 2.0 in addition of web 2.0 tools usage as a good communication tools, Cultural interaction, Consultation & association in a free Environment are very important too.
Weighted simplicial complexes and their representation power of higher-order network data and topology
Creators: name: Baccini, Federica
name: Geraci, Filippo
name: Bianconi, Ginestra
Publisher: name: arXiv
Year: 2022
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Computational Geometry (cs.CG)
subject: Social and Information Networks (cs.SI)
subject: Algebraic Topology (math.AT)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences
subject: FOS: Mathematics
subject: J.2

description: Hypergraphs and simplical complexes both capture the higher-order interactions of complex systems, ranging from higher-order collaboration networks to brain networks. One open problem in the field is what should drive the choice of the adopted mathematical framework to describe higher-order networks starting from data of higher-order interactions. Unweighted simplicial complexes typically involve a loss of information of the data, though having the benefit to capture the higher-order topology of the data. In this work we show that weighted simplicial complexes allow to circumvent all the limitations of unweighted simplicial complexes to represent higher-order interactions. In particular, weighted simplicial complexes can represent higher-order networks without loss of information, allowing at the same time to capture the weighted topology of the data. The higher-order topology is probed by studying the spectral properties of suitably defined weighted Hodge Laplacians displaying a normalized spectrum. The higher-order spectrum of (weighted) normalized Hodge Laplacians is here studied combining cohomology theory with information theory. In the proposed framework, we quantify and compare the information content of higher-order spectra of different dimension using higher-order spectral entropies and spectral relative entropies. The proposed methodology is tested on real higher-order collaboration networks and on the weighted version of the simplicial complex model "Network Geometry with Flavor".
description: 20 pages, 11 figures
Hydrochus pertuberculatus Perkins
Creators: name: Perkins, Philip D.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Hydrochidae
Hydrochus
Hydrochus pertuberculatus

description: Hydrochus pertuberculatus Perkins
Figs. 1, 35
Hydrochus pertuberculatus Perkins 2020a: 297.
Originally described from Guatemala. Following are new locality data records for Guatemala and Mexico. Images of the habitus and male genitalia of the holotype, and detailed description of the male genitalia are given in Perkins (2020a).
Material examined (10): Guatemala: Peten, Parque National El Rosario, E of Sayaxche, (16°31’26.9’’N, 90°9’36.32’’W), 2-3.x.2013, leg. R. S. Zack (1 WSU). Mexico: Cotaxtla, Cotaxtla Exp. Sta., 1.vii.1962, leg. D. H. Janzen (1 NMNH); Chiapas, 5 Mi. S. Las Cruces, 23.viii.1965, leg. Paul J. Spangler (3 NMNH); Veracruz, 20 mi. NW Rt. 144 Huatusco, 28.vi.1963, leg. Robt. E. Woodruff (4 NMNH); Cordoba, 19 mi. NE, 1.vii.1952, leg. collector unknown (1 SEMC).
Differential diagnosis. Among Central American species, recognized by the combination of moderately large size (ca. 3.56 mm), the moderately low and relatively impunctate pronotal reliefs, the large tubercle of the 5 th interstria, and the male genitalia. This species has a generalized Hydrochus habitus; reliable determinations will require dissection of males. The male genitalia are superficially somewhat similar to that of H. nayaritensis n. sp., in being slender and having a very narrow aedeagus; however, the parameres, especially the sagittate tips, the basal piece shape, and the adbl shape and size are very different in H. pertuberculatus.
description: Published as part of Perkins, Philip D., 2021, Taxonomy of Central American water beetles in the genus Hydrochus Leach, 1817 (Coleoptera: Hydrochidae), pp. 459-503 in Zootaxa 4974 (3) on page 478, DOI: 10.11646/zootaxa.4974.3.2, http://zenodo.org/record/4777839
Unbiased water and methanol maser surveys of NGC 1333
Creators: name: Lyo, A-Ran
name: Kim, Jongsoo
name: Byun, Do-Young
name: Lee, Ho-Gyu
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present the results of unbiased 22 GHz H2O water and 44 GHz class I CH3OH methanol maser surveys in the central 7x10 arcmin area of NGC 1333 and two additional mapping observations of a 22 GHz water maser in a ~3x3arcmin area of the IRAS4A region. In the 22 GHz water maser survey of NGC 1333 with sensitivity of sigma~0.3Jy, we confirmed masers toward H2O(B) in the region of HH 7-11 and IRAS4B. We also detected new water masers at ~20arcsec away in the western direction of IRAS4B or ~25arcsec away in the southern direction of IRAS4A. We could not however find young stellar objects or molecular outflows associated with them. They showed two different velocity components of ~0 and ~16 km/s, which are blue- and red-shifted relative to the adopted systemic velocity of ~7 km/s for NGC 1333. They also showed time variabilities in both intensity and velocity from multi-epoch observations and an anti-correlation between the intensities of the blue- and the red-shifted velocity components. We suggest that the unidentified powering source of these masers might be in the earliest evolutionary stage of star formation before the onset of molecular outflows. Finding this kind of water masers is only possible by an unbiased blind survey. In the 44 GHz methanol maser survey with sensitivity of sigma~0.5 Jy, we confirmed masers toward the IRAS4A2 and the eastern shock region of the IRAS2A. Both sources are also detected in 95 and 132 GHz methanol maser lines. In addition, we had new detections of methanol masers at 95 and 132 GHz toward IRAS4B. In terms of the isotropic luminosity, we detected the methanol maser sources brighter than ~5x1025 erg/s from our unbiased survey.
description: 20 pages including 5 figures, accepted by AJ
A Phenomics-Based Strategy Identifies Loci on APOC1, BRAP, and PLCG1 Associated with Metabolic Syndrome Phenotype Domains
Creators: name: Heiss, Gerardo
name: North, Kari E.
name: Pendergrass, Sarah A.
name: Ambite, Jose L.
name: Wilkens, Lynne R.
name: Kooperberg, Charles
name: Fornage, Myriam
name: Boerwinkle, Eric
name: Ritchie, Marylyn D.
name: Rotter, Jerome I.
name: Pankow, James S.
name: Hindorff, Lucia A.
name: Lin, Dan Yu
name: Avery, Christy L.
name: Meigs, James B.
name: He, Qianchuan
name: Psaty, Bruce M.
name: Taylor, Kent D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Despite evidence of the clustering of metabolic syndrome components, current approaches for identifying unifying genetic mechanisms typically evaluate clinical categories that do not provide adequate etiological information. Here, we used data from 19,486 European American and 6,287 African American Candidate Gene Association Resource Consortium participants to identify loci associated with the clustering of metabolic phenotypes. Six phenotype domains (atherogenic dyslipidemia, vascular dysfunction, vascular inflammation, pro-thrombotic state, central obesity, and elevated plasma glucose) encompassing 19 quantitative traits were examined. Principal components analysis was used to reduce the dimension of each domain such that >55% of the trait variance was represented within each domain. We then applied a statistically efficient and computational feasible multivariate approach that related eight principal components from the six domains to 250,000 imputed SNPs using an additive genetic model and including demographic covariates. In European Americans, we identified 606 genome-wide significant SNPs representing 19 loci. Many of these loci were associated with only one trait domain, were consistent with results in African Americans, and overlapped with published findings, for instance central obesity and FTO. However, our approach, which is applicable to any set of interval scale traits that is heritable and exhibits evidence of phenotypic clustering, identified three new loci in or near APOC1, BRAP, and PLCG1, which were associated with multiple phenotype domains. These pleiotropic loci may help characterize metabolic dysregulation and identify targets for intervention.
Enhanced Statistical Tests for GWAS in Admixed Populations: Assessment using African Americans from CARe and a Breast Cancer Consortium
Creators: name: Nyante, Sarah J.
name: Lange, Leslie A.
name: Press, Michael F.
name: Bandera, Elisa V.
name: Cupples, L. Adrienne
name: Musani, Solomon K.
name: Lettre, Guillaume
name: Zheng, Wei
name: Ingles, Sue A.
name: Bernstein, Leslie
name: Chen, Gary K.
name: Zaitlen, Noah
name: Siscovick, David S.
name: Yang, Qiong
name: John, Esther M.
name: Li, Mingyao
name: Chanock, Stephen J.
name: Hu, Jennifer J.
name: Akylbekova, Ermeg L.
name: Zhu, Xiaofeng
name: Millikan, Robert C.
name: Divers, Jasmin
name: Larkin, Emma
name: Kao, W. H. Linda
name: Pasaniuc, Bogdan
name: Ruczinski, Ingo
name: Mychaleckyj, Joe
name: Ambrosone, Christine B.
name: Tandon, Arti
name: Fornage, Myriam
name: Ziegler, Regina G.
name: Papanicolaou, George J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: While genome-wide association studies (GWAS) have primarily examined populations of European ancestry, more recent studies often involve additional populations, including admixed populations such as African Americans and Latinos. In admixed populations, linkage disequilibrium (LD) exists both at a fine scale in ancestral populations and at a coarse scale (admixture-LD) due to chromosomal segments of distinct ancestry. Disease association statistics in admixed populations have previously considered SNP association (LD mapping) or admixture association (mapping by admixture-LD), but not both. Here, we introduce a new statistical framework for combining SNP and admixture association in case-control studies, as well as methods for local ancestry-aware imputation. We illustrate the gain in statistical power achieved by these methods by analyzing data of 6,209 unrelated African Americans from the CARe project genotyped on the Affymetrix 6.0 chip, in conjunction with both simulated and real phenotypes, as well as by analyzing the FGFR2 locus using breast cancer GWAS data from 5,761 African-American women. We show that, at typed SNPs, our method yields an 8% increase in statistical power for finding disease risk loci compared to the power achieved by standard methods in case-control studies. At imputed SNPs, we observe an 11% increase in statistical power for mapping disease loci when our local ancestry-aware imputation framework and the new scoring statistic are jointly employed. Finally, we show that our method increases statistical power in regions harboring the causal SNP in the case when the causal SNP is untyped and cannot be imputed. Our methods and our publicly available software are broadly applicable to GWAS in admixed populations.
Emergence of $p+ip$ superconductivity in $2$D strongly correlated Dirac fermions
Creators: name: Gu, Zheng-Cheng
name: Jiang, Hong-Chen
name: Baskaran, G.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Superconductivity (cond-mat.supr-con)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Searching for $p+ip$ superconducting(SC) state has become a fascinating subject in condensed matter physics, as a dream application awaiting in topological quantum computation. In this paper, we report a theoretical discovery of a $p+ip$ SC ground state (coexisting with ferromagnetic order) in honeycomb lattice Hubbard model with infinite repulsive interaction at low doping($δ< 0.2$), by using both the state-of-art Grassmann tensor product state(GTPS) approach and a quantum field theory approach. Our discovery suggests a new mechanism for $p+ip$ SC state in generic strongly correlated systems and opens a new door towards experimental realization. The $p+ip$ SC state has an instability towards a potential non-Fermi liquid with a large but finite $U$. However, a small Zeeman field term stabilizes the $p+ip$ SC state. Relevant realistic materials are also proposed.
description: 7 pages, 5 figures