cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Evaluation of the Effectiveness of Herbal Components Based on Their Regulatory Signature on Carcinogenic Cancer Cells
Creators: name: Esmaeili, F
name: Lohrasebi, T
name: Mohammadi Dehcheshmeh, Manijeh
name: Ebrahimie, Esmaeil
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3102
subject: Bioinformatics and computational biology
classificationCode: 32
subject: Biomedical and clinical sciences

description: Predicting cancer cells’ response to a plant-derived agent is critical for the drug discovery process. Recently transcriptomes advancements have provided an opportunity to identify regulatory signatures to predict drug activity. Here in this study, a combination of meta-analysis and machine learning models have been used to determine regulatory signatures focusing on differentially ex-pressed transcription factors (TFs) of herbal components on cancer cells. In order to increase the size of the dataset, six datasets were combined in a meta-analysis from studies that had evaluated the gene expression in cancer cell lines before and after herbal extract treatments. Then, categorical feature analysis based on the machine learning methods was applied to examine transcription factors in order to find the best signature/pattern capable of discriminating between control and treated groups. It was found that this integrative approach could recognize the combination of TFs as predictive biomarkers. It was observed that the random forest (RF) model produced the best combination rules, including AIP/TFE3/VGLL4/ID1 and AIP/ZNF7/DXO with the highest modulating capacity. As the RF algorithm combines the output of many trees to set up an ultimate model, its predictive rules are more accurate and reproducible than other trees. The discovered regulatory signature suggests an effective procedure to figure out the efficacy of investigational herbal compounds on particular cells in the drug discovery process.
Nature and society in marine research - Perspectives for interdisciplinary cooperation in the Anthropocene
Creators: name: Bogusz, Tanja
name: Holtappels, Moritz
name: Hodapp, Dorothee
name: Schlüter, Achim
name: Breckwoldt, Annette
Publisher: name: Zenodo
Year: 2024

description: The human-induced environmental crises are becoming increasingly clear and visible; in the oceans just as on land. The natural and technical sciences in particular have contributed to raising public awareness of the threatened state of the oceans and coasts through large-scale research initiatives. However, the results and recommendations to date have not yet led to effective societal action. This requires a better understanding of the interactions between social and ecological processes. In order to capture these interactions, cooperation between the major disciplinary groups of the natural and technical sciences on the one hand, and the social and cultural sciences on the other must be significantly intensified and professionalized. This cooperation requires structural support and strategically viable implementation in research and training. Against the background of the ongoing UN-Decade of Ocean Science for Sustainable Development (2021-2030), this position paper presents five areas of development for future interdisciplinary marine research and puts them up for discussion: 1. Establishing connectivity between academic scientific cultures; 2. Reforms in training to professionalize interdisciplinary research and teaching; 3. Reforms of marine research organisations; 4. Adaptation of project funding and project organisation and 5. Structural opening into society. In summary, we conclude that interdisciplinary research requires not only the expertise of the individual disciplines but also a reflection on the different scientific cultures in order to identify the conditions and potential for collaboration. Interdisciplinary collaboration then arises from a solution-oriented view of jointly defined problems, so that solutions can be based on both natural and social knowledge. This can be promoted by aligning funding objectives with action knowledge and by taking interdisciplinary needs into account at the operational level (networking and determining phases for the recruitment of potential partners). The development of interdisciplinary excellence, however, also requires a development path for interdisciplinary scientific training, providing the basis for both transdisciplinary and non-academic careers. The establishment of interdisciplinary assessment mechanisms in the various evaluation committees is also important, and these should be multidisciplinary and equipped with interdisciplinary expertise. At the same time, there is a need to expand interdisciplinary competence in the individual research institutions, in turn contributing to the structured expansion of transdisciplinary cooperation with non-academic actors.
Proposal For Offering Tex Courses And Relevant Resources In Chongqing University
Creators: name: LI Zhennan
name: WU Chenyu
name: LIU Chunlei
name: ZHAO Pinyong
Publisher: name: Zenodo
Year: 2016
Subjects: TeX Courses
LaTeX Training
Chongqing University
Proposal
CTAN Mirror

description: UPDATED VERSION available at Github: https://github.com/CQUtug/TeXProposal

The present proposal mainly explains the importance and necessity of introducing TeX, a typeset system often used in academic writing, to students and teachers as the counterpart of Microsoft Word. This proposal starts from a brief introduction of TeX, then steps further into its fascinating application on academic writing and dissertation formatting. In the end, a set of possible implementation strategies with regard to the proper introduction of TeX and relevant resources to our university, is proposed.
Visual scanpath training to emotional faces following severe traumatic brain injury: A single case design
Creators: name: Vassallo, Suzane
name: Douglas, Jacinta
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 52
subject: Psychology
subject: FOS: Psychology
classificationCode: 5202
subject: Biological psychology
classificationCode: 5204
subject: Cognitive and computational psychology

description: The visual scanpath to emotional facial expressions was recorded in BR, a 35-year-old male with chronic severe traumatic brain injury (TBI), both before and after he underwent intervention. The novel intervention paradigm combined visual scanpath training with verbal feedback and was implemented over a 3-month period using a single case design (AB) with one follow up session. At baseline BR's scanpath was restricted, characterised by gaze allocation primarily to salient facial features on the right side of the face stimulus. Following intervention his visual scanpath became more lateralised, although he continued to demonstrate an attentional bias to the right side of the face stimulus. This study is the first to demonstrate change in both the pattern and the position of the visual scanpath to emotional faces following intervention in a person with chronic severe TBI. In addition, these findings extend upon our previous work to suggest that modification of the visual scanpath through targeted facial feature training can support improved facial recognition performance in a person with severe TBI.
HPTLC and FTIR Fingerprinting of Olive Leaves Extracts and ATR-FTIR Characterisation of Major Flavonoids and Polyphenolics
Creators: name: Kustrin, Snezana
name: Gegechkori, V
name: Petrovich, DS
name: Ilinichna, KT
name: Morton, David
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 34
subject: Chemical sciences
subject: FOS: Chemical sciences
classificationCode: 3404
subject: Medicinal and biomolecular chemistry
classificationCode: 3405
subject: Organic chemistry

description: The aim of this study was to analyse the effect of spontaneous microbial maceration on the release and extraction of the flavonoids and phenolics from olive leaves. Bioprofiling based on thin-layer chromatography effect-directed detection followed by ATR-FTIR spectroscopy proved to be a reliable and convenient method for simultaneous comparison of the extracts. Results show that fermentation significantly enhances the extraction of phenolic compounds and flavonoids. The polyphenolic content was increased from 6.7 µg GAE (gallic acid equivalents) to 25.5 µg GAE, antioxidants from 10.3 µg GAE to 25.3 µg GAE, and flavonoid content from 42 µg RE (rutin equiv-alents) to 238 µg RE per 20 µL of extract. Increased antioxidant activity of fermented ethyl acetate extracts was attributed to the higher concentration of extracted flavonoids and phenolic terpenoids, while increased antioxidant activity in fermented ethanol extract was due to increased extraction of flavonoids as extraction of phenolic compounds was not improved. Lactic acid that is released during fermentation and glycine present in the olive leaves form a natural deep eutectic solvent (NADES) with significantly increased solubility for flavonoids.
Winners and Losers in Palliative Care Service Delivery: Time for a Public Health Approach to Palliative and End of Life Care
Creators: name: Aoun, Samar
name: Richmond, R
name: Jiang, L
name: Rumbold, Bruce
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4203
subject: Health services and systems

description: Background: Consumer experience of palliative care has been inconsistently and selectively investigated. Methods: People in Western Australia who had experienced a life limiting illness in the past five years were recruited via social media and care organisations (2020) and invited to complete a cross sectional consumer survey on their experiences of the care they received. Results: 353 bereaved carers, current carers and patients responded. The winners, those who received the best quality end-of-life care, were those who were aware of palliative care as an end-of-life care (EOLC) option, qualified for admission to and were able to access a specialist palliative care program, and with mainly a cancer diagnosis. The losers, those who received end-of-life care that was adequate rather than best practice, were those who were unaware of palliative care as an EOLC option or did not qualify for or were unable to access specialist palliative care and had mainly a non-cancer diagnosis. Both groups were well supported throughout their illness by family and a wider social network. However, their family carers were not adequately supported by health services during caregiving and bereavement. Conclusions: A public health approach to palliative and end of life care is proposed to integrate tertiary, primary, and community services through active consumer engagement in the design and delivery of care. Therefore, suggested strategies may also have relevance in many other international settings.
Post-traumatic Stress Disorder and Associated Factors 1 Year After the Beginning of the COVID-19 Pandemic Among Chinese Residents
Creators: name: Shen, X
name: Yan, S
name: Jiang, Heng
name: Cao, H
name: Dowling, Rowan
name: Feng, J
name: Lei, Z
name: Li, J
name: Han, X
name: Lv, C
name: Gan, Y
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences

description: Background: By investigating the incidence of post-traumatic stress disorder (PTSD) among residents during a period of low transmission, this study reflects the long-term impact of coronavirus disease 2019 (COVID-19) and identify which categories of residents are more likely to develop PTSD due to an acute infectious disease crisis, facilitating the development of targeted strategies to protect mental health after outbreaks of similar acute infectious diseases in the future. Methods: A cross-sectional survey was conducted in China from 4 to 26 February 2021. A convenience sampling strategy was adopted to recruit participants. Participants were asked to complete the PTSD Checklist for DSM-5 (PCL-5). A multivariable linear stepwise regression analysis model was used to identify which factors were associated with PTSD in residents of China. Results: A total of 2,361 Chinese residents completed the questionnaire. The mean PCL-5 score for the respondents was 13.65 (SD = 8.66), with 219 (9.28%) patients having probable PTSD symptoms. Respondents who were female (β = 0.038), had a relative or friend who had contracted COVID-19 (β = 0.041), and had poor health (β = 0.184) had higher PCL-5 scores, while the population aged over 60 years (β = −0.063), who agreed that COVID-19 information was released in a timely manner (β = −0.347), who had experienced a relatively limited impact of COVID-19 on their life (β = −0.069), and who agreed that the local prevention initiatives were sophisticated (β = −0.165) had lower PTSD scores. Conclusions: Outbreaks of acute infectious diseases can have long-term psychological health effects in the general population. In addition, health policy makers need to be concerned about and implement measures to support the mental health of vulnerable groups.
Introduction. The Spirit of International Solidarity, the Right to Asylum, and the Response to Displacement
Creators: name: Boyd, Jodie
name: Taylor, Savitri
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 44
subject: Human society
classificationCode: 48
subject: Law and legal studies
classificationCode: 4807
subject: Public law
classificationCode: 50
subject: Philosophy and religious studies

description: No description supplied
title: A Design of Experiments Approach to Deck Flow Characterization on an Aircraft Carrier
Creators: name: Wing, Yugapriya Sivanesan
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 2007

description: A wind tunnel model of an aircraft carrier was used to make air wake measurements. Particle image velocimetry measurements of turbulence intensity were made on a center plane intersecting the angled deck of the aircraft carrier. The factors of interest for the study were model pitch, yaw, island location, and island type. Two island types were used, a representative shape of current designs and an ideal streamlined airfoil shape. Each factor was studied at two levels in order to provide linear models using a Design of Experiments factorial design. From the data for each experimental combination, regression models for turbulence intensity were generated for five locations along the glide slope of an aircraft landing on the angled deck. Tests were also done to check the validity of the linear models. The models generated by the designed experiment were used to give recommendations on what factor settings result in the largest reduction of turbulence intensity along the glide slope. Also generated from the experiment were contour plots of velocity and turbulence intensity and line plots showing the turbulence and velocity trends along the glide slope.
Network meta-analysis for comparative effectiveness of treatments for chronic low back pain disorders: Systematic review protocol
Creators: name: Belavy, DL
name: Diwan, AD
name: Ford, Jon
name: Miller, CT
name: Hahne, Andrew
name: Mundell, N
name: Tagliaferri, S
name: Bowe, S
name: Pedder, H
name: Saueressig, T
name: Zhao, X
name: Chen, X
name: Balasundaram, AP
name: Arora, NK
name: Owen, PJ
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4201
subject: Allied health and rehabilitation science
classificationCode: 4208
subject: Traditional, complementary and integrative medicine
classificationCode: 52
subject: Psychology
subject: FOS: Psychology

description: Introduction: Chronic low back pain disorders (CLBDs) present a substantial societal burden; however, optimal treatment remains debated. To date, pairwise and network meta-analyses have evaluated individual treatment modes, yet a comparison of a wide range of common treatments is required to evaluate their relative effectiveness. Using network meta-analysis, we aim to evaluate the effectiveness of treatments (acupuncture, education or advice, electrophysical agents, exercise, manual therapies/manipulation, massage, the McKenzie method, pharmacotherapy, psychological therapies, surgery, epidural injections, percutaneous treatments, traction, physical therapy, multidisciplinary pain management, placebo, 'usual care' and/or no treatment) on pain intensity, disability and/or mental health in patients with CLBDs. Methods and analysis: Six electronic databases and reference lists of 285 prior systematic reviews were searched. Eligible studies will be randomised controlled/clinical trials (including cross-over and cluster designs) that examine individual treatments or treatment combinations in adult patients with CLBDs. Studies must be published in English, German or Chinese as a full-journal publication in a peer-reviewed journal. A narrative approach will be used to synthesise and report qualitative and quantitative data, and, where feasible, network meta-analyses will be performed. Reporting of the review will be informed by Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidance, including the network meta-analysis extension (PRISMA-NMA). The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach for network meta-analysis will be implemented for assessing the quality of the findings.
FluidNET Science Conference Abstract - Fluid inclusion isotopic signals from Variscan quartz veins using a new CRDS method
Creators: name: Akbar Huseynov
name: H.J.L. van der Lubbe
name: S.J.A. Verdegaal – Warmerdam
name: O. Postma
Publisher: name: Zenodo
Year: 2024

description: Fluid inclusion isotopic signals from Variscan quartz veins using a new CRDS method

 

Akbar Aydin Oglu Huseynov, H.J.L van der Lubbe, S.J.A. Verdegaal – Warmerdam, O. Postma

Vrije Universiteit Amsterdam

a.huseynov@vu.nl

 

Fluid inclusions of quartz veins are essential for determining the pathways of fluids flow in the subsurface. In this study, we provide a new method for analysing the isotopic composition of fluid inclusion water via Cavity Ring-Down Spectroscopy (CRDS). The CRDS is connected to a mechanical crusher to release fluid inclusion water from the mineral it is contained in, at a temperature of around 120°C. The water vapour from the pulverised sample is introduced into a wet background that has a consistent composition and concentration of oxygen and hydrogen isotopes. The Earth Science Stable Isotope Laboratory at the Vrije Universiteit Amsterdam (VU) has designed a temperature-controlled evaporation system that ensures a consistently stable background.

 

This newly designed configuration offers accurate measurements of the combined oxygen and hydrogen isotope compositions from quartz grains. In this work, we examined quartz veins from Germany and Portugal that are associated with the Variscan orogeny. The isotopes results are consistent with the current Global Meteoric Water Line and indicate the meteoric impact on this fold-and-thrust belt. The silicon and oxygen isotopic characteristics of quartz crystals, together with microthermometric studies, provide evidence of the hydrothermal system undergoing cooling at various phases of the Variscan orogeny, in conjunction with the isotopic data obtained from fluid inclusions. This technique enables direct measurement of isotopic compositions of fluid inclusions, offering a quicker and more efficient alternative to current approaches. Moreover, it may be used to a wide range of minerals and geological environments.

 

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 956127
Building Preservice Teachers’ Confidence for Teaching and Learning STEM, Incorporating Innovative, Interdisciplinary, and Integrated (3I) Initiatives
Creators: name: Kurup, Premnadh
name: Li, Xia
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 39
subject: Education
classificationCode: 3901
subject: Curriculum and pedagogy
classificationCode: 3903
subject: Education systems

description: No description supplied
Проблема корневых гнилей пшеницы в современных агротехнологиях Зауралья
Creators: name: Немченко, Владимир Васильевич
name: Кекало, Алёна Юрьевна
Publisher: name: Zenodo
Year: 2024

description: Корневая гниль яровой пшеницы относится к вредоносным заболеваниям. В условиях УрФО, Сибири, Северного Казахстана распространены гельминтоспориозная и фузариозная корневая гниль, первичными возбудителями являются различные виды грибов рода Fusarium и гриб Bipolaris sorokiniana. Увеличение в регионе доли агротехнологии со снижением интенсивности обработки почвы помимо положительных результатов по снижению эрозионной опасности и улучшению условий воспроизведения почвенного плодородия, имеет и ряд негативных моментов, в частности усиление фитосанитарных рисков. Целью исследования было уточнение возбудителей корневой гнили пшеницы яровой и соотношение их при различных способах обработки почвы в зернопаровом севообороте и бессменном возделывании культуры в Зауралье. Проведены исследования были на базе многолетних стационарных опытов Курганского НИИСХ – филиала ФГБНУ УрФАНИЦ УрО РАН в 2021-2022 гг. Выяснено, что при использовании отвальной технологии обработки почвы доминирует обыкновенная корневая гниль, при снижении интенсивности почвообработки отмечается преобладание грибов рода Fusarium. Доминирующими являлись опасные виды F. oxysporum, F. sporotrichioides, F. graminearum.
FluidNET Science Conference Abstract - How do metamorphic fluids influence metamorphic rock time records?
Creators: name: Clare J. Warren
name: Sander Hoogendoorn
name: S.J. Kersley
name: C.J. Oldman
name: Barbara E. Kunz
name: N.M.W. Roberts
name: T.W. Argles
name: A.M. Halton
Publisher: name: Zenodo
Year: 2024

description: How do metamorphic fluids influence metamorphic rock time records?

 

C.J. Warren1*, S.B. Hoogendoorn1, S.J. Kersley1, C.J. Oldman1, B.E. Kunz1, N.M.W. Roberts, T.W. Argles1, A.M. Halton1

1School of Environment, Earth and Ecosystem Sciences, The Open University, Walton Hall, Milton Keynes, MK7 6AA, UK

2Geochronology and Tracers Facility, British Geological Survey, Keyworth, NG12 5GG, UK

* clare.warren@open.ac.uk

 

The modern field of petrochronology has made significant advances in linking “age to stage” and “date to rate” over the last decade. Through application of petrochronological techniques, it has become increasingly obvious that metamorphic cycles take place over tens of millions of years.  The extent to which metamorphism proceeds as a series of steps or as more of a continuous process in different lithologies and different tectonic settings is still unclear.  

 

Crustal fluids – including silicate melts and hydrous fluids – play an important, but not always fully considered, role in catalysing and driving chronometer reactions.  Fluids may promote crystallisation, thus starting the record, or may erase or erode an earlier history through promoting dissolution, alteration or thermal disturbance. The result can be a patchy geochronological record across a sample suite, which might appear recorded as one protracted event rather than individual stages. This contribution will explore how combinations of geochronological data, independent geochemical datasets, petrological observations and modelling provide a strong foundation to constrain the timing, timescales and pulsed or continuous evolution of metamorphic processes to be constrained more tightly.

 

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 956127
Comprehensive Evaluation and Application of Special Medicinal Materials Germplasm Resources
Creators: name: 陈芳(ChenFang)
Publisher: name: CNGB
Year: 2025
Subjects: Raw sequence reads
Multiisolate
Agricultural

description: The development of genome-wide genetic markers to evaluate genetic diversity and phylogenetic relationships of germplasm resources. The research findings will lay the foundation for genetic breeding studies and the establishment of germplasm fingerprinting.
Community-based social interventions for people with severe mental illness: a systematic review and narrative synthesis of recent evidence
Creators: name: Killaspy, Helen
name: Harvey, Carol
name: Brasier, Catherine
name: Brophy, Lisa
name: Ennals, Priscilla
name: Fletcher, Justine
name: Hamilton, Bridget
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 3202
subject: Clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4201
subject: Allied health and rehabilitation science
classificationCode: 4203
subject: Health services and systems

description: No description supplied
I teach; therefore, I lead: teacher leadership and teacher evaluation to enhance the effectiveness of Greek primary schools
Creators: name: Chasioti, Vasiliki
Publisher: name: Anglia Ruskin Research Online (ARRO)
Year: 2025

description: This research investigates teachers' perceptions of teacher leadership and teacher evaluation. This research also examines the connection between teacher evaluation and teacher leadership in a context of distributed leadership, based on the "Critical Pedagogy" model, suggesting that teachers should be committed to emancipatory educational practices rather than simple transmission of skills and knowledge. Hence, this study draws on a wide range of research literature to explore the available empirical data on teacher leadership and evaluation. In a mixed-methods approach, an exploratory sequential mixed-methods design is selected. The sample of participants consists of 372 primary school teachers and headteachers of an urban area in Greece. Based on specific criteria, fifteen volunteers were selected among the respondents to participate in semi-structured interviews. Results were analysed using descriptive and inferential statistics as well as thematic and discourse analysis before being presented in a comprehensive interpretation. The research shows that the participants' views on teacher leadership inform their views on teacher evaluation. Most teachers participating in the study believe that primary education teachers act as leaders in their educational community. Most respondents are favourably disposed towards teacher evaluation. The factors of age, work status (headteachers, deputy headteachers, permanent or substitute teachers), and years of service in the same school affect teachers` perceptions of teacher leadership. The themes of time, trust and training are linked with teacher leadership and evaluation. This research provides empirical evidence about the potential of teacher leadership and explores a new model of teacher evaluation linked to the role of teacher leaders. Additionally, the study provides insight into teachers` perceptions of an optimum evaluation model, the Teacher Leadership for Teacher Evaluation Model, designed to help teachers improve their professional practice and contribute to school effectiveness. Ultimately, this research brings together the ideas of critical pedagogy and distributed leadership models, indicating that they are compatible educational approaches leading to school effectiveness by empowering teachers to act as leaders in their schools and take ownership of their evaluation.
Enacting Safety and Omitting Gender: Australian Human Rights Scrutiny Processes Concerning Alcohol and Other Drug Laws
Creators: name: Seear, Kate
name: Mulcahy, Sean
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 44
subject: Human society

description: No description supplied.
Enacting Safety and Omitting Gender: Australian Human Rights Scrutiny Processes Concerning Alcohol and Other Drug Laws
Creators: name: Seear, Kate
name: Mulcahy, Sean
Publisher: name: La Trobe
Year: 2022

description: Global momentum for drug law reform is building. But how might such reform be achieved? Many argue that human rights offer a possible normative framework for guiding such reform. There has been very little research on whether human rights processes can actually achieve such aims, however. This paper responds to this knowledge gap. It explores how one human rights mechanism—the “parliamentary rights scrutiny process”—deals with alcohol and other drugs. We consider how four Australian parliaments scrutinized proposed new laws that would deal with alcohol and other drugs for their human rights “compatibility.” We find that laws that would limit the rights of people who use alcohol and other drugs were routinely seen as justifiable on the basis that alcohol and other drugs were inherently “unsafe.” Crucially, safety was conceptualized in a gender-neutral way, without regard to the potential role of gender, including specific masculinities, in the production of phenomena such as family violence and sexual violence and other public safety problems. Instead, such problems were regularly constituted as consequences, simply, of alcohol or other drug consumption. In making this argument, we build on the pioneering work of David Moore and colleagues (e.g., 2020). Their work asks important questions about how the causes of violence are constituted across different settings, including research and policy. Drawing on ideas from scholars such as Carol Bacchi and John Law, they identify “gendering practices” and “collateral realities” in research and policy on violence, in which the role of men and masculinities are routinely obscured, displaced or rendered invisible. We find similar problems underway within human rights law. In highlighting these gendering practices and collateral realities, we aim to draw attention to the limitations of some human rights processes and the need for more work in this area.
Value attitude behaviour and social stigma in the adoption of veganism: An integrated model
Creators: name: Brouwer, Anne
name: D'Souza, Clare
name: Singaraju, Stephen
name: Arango-Soler, LA
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 3006
subject: Food sciences
classificationCode: 3210
subject: Nutrition and dietetics
classificationCode: 35
subject: Commerce, management, tourism and services
classificationCode: 3503
subject: Business systems in context
classificationCode: 350304
subject: Business systems in context
classificationCode: 3506
subject: Marketing
subject: FOS: Economics and business

description: While veganism has been growing and receiving increasing attention, there is a gap on how factors such as health and environmental beliefs and anti-speciesism values, that create attitude towards their diets, influence their vegan behaviour. Furthermore, the role of social stigma experienced by vegans has not been examined within this context. Building on the value-attitude-behaviour model, the present study addresses this gap by conceptualizing these different streams of variables to build a testable conceptual framework for understanding how these factors contribute to maintaining a vegan lifestyle. The study uses structural equation modelling to analyse the data on 315 vegan consumers, testing the framework and its variables. The study shows that the value‐attitude‐behaviour model can successfully be applied to vegan behaviour. The findings show that anti-speciesism values are strong predictors of a positive attitude toward a vegan diet. Furthermore, social stigma does not inhibit consumers from maintaining a vegan lifestyle. Ultimately, the study contributes to a novel multifaceted model for understanding veganism in broader terms, allowing for the examination of other influencing factors on a complex outcome. The findings are useful for policymakers and marketing practitioners to engage in understanding behavioural segments.
Footwear comfort: a systematic search and narrative synthesis of the literature
Creators: name: Menz, Hylton
name: Bonanno, Daniel
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 3202
subject: Clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4201
subject: Allied health and rehabilitation science
classificationCode: 4207
subject: Sports science and exercise

description: Objective: To provide a narrative synthesis of the research literature pertaining to footwear comfort, including definitions, measurement scales, footwear design features, and physiological and psychological factors. Methods: A systematic search was conducted which yielded 101 manuscripts. The most relevant manuscripts were selected based on the predetermined subheadings of the review (definitions, measurement scales, footwear design features, and physiological and psychological factors). A narrative synthesis of the findings of the included studies was undertaken. Results: The available evidence is highly fragmented and incorporates a wide range of study designs, participants, and assessment approaches, making it challenging to draw strong conclusions or implications for clinical practice. However, it can be broadly concluded that (i) simple visual analog scales may provide a reliable overall assessment of comfort, (ii) well-fitted, lightweight shoes with soft midsoles and curved rocker-soles are generally perceived to be most comfortable, and (iii) the influence of sole flexibility, shoe microclimate and insoles is less clear and likely to be more specific to the population, setting and task being performed. Conclusion: Footwear comfort is a complex and multifaceted concept that is influenced not only by structural and functional aspects of shoe design, but also task requirements and anatomical and physiological differences between individuals. Further research is required to delineate the contribution of specific shoe features more clearly, and to better understand the interaction between footwear features and individual physiological attributes.
Examining the complexities of support for decision-making practice
Creators: name: Bigby, Christine
name: Douglas, Jacinta
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 44
subject: Human society
classificationCode: 4409
subject: Social work
classificationCode: 52
subject: Psychology
subject: FOS: Psychology
classificationCode: 5204
subject: Cognitive and computational psychology

description: No description supplied
PRME Chapter Australia and New Zealand
Creators: name: Nejati, Mehran
name: Gibbons, Belinda
name: Suri, Harsh
name: Azmat, Fara
name: Young-Ferris, Anna
name: Young, Suzanne
name: Nagpal, Swati
Publisher: name: La Trobe
Year: 2021
Subjects: classificationCode: 39
subject: Education
classificationCode: 3902
subject: Education policy, sociology and philosophy
classificationCode: 3904
subject: Specialist studies in education

description: What is our why and what motivates us to be here? These questions keep the Australia and New Zealand (AUSNZ) PRME Chapter conversations and actions grounded and relevant. This chapter presents our collaborations locally and internationally.
Lessons learned: Anticipatory action in a protracted crisis
Creators: name: Grace, Joanne
Publisher: name: Save the Children
Year: 2024
Subjects: anticipatory action
drought
early action

description: The Jameel Observatory for Food Security Early Action funded this research
description: This paper provides key lessons from research into the effectiveness of anticipatory action carried out in Kenya and Somaliland during a protracted crisis. The research was conducted from 2021–2024 with the Jameel Observatory for Food Security Early Action and sought to better understand how anticipatory action can help prevent extreme weather events from turning into disasters that harm lives, livelihoods, and children’s futures.
Embedding wholistic learning: Designing curated eLearning processes for social work students
Creators: name: Atkins, Prue
name: Sykes, Katie
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 39
subject: Education
classificationCode: 3901
subject: Curriculum and pedagogy
classificationCode: 3903
subject: Education systems
classificationCode: 44
subject: Human society
classificationCode: 4409
subject: Social work

description: La Trobe University is implementing a new Social Work course. Several evidence-based curriculum design and teaching innovations have been identified as having the potential to support both new explicit and implicit curriculum. This paper reports on the introduction of an innovative learning technology solution to promote a student centred learning approach. The use of the technology is novel to social work coursework education so evaluating the impact on supporting learning outcomes addresses a current gap in the research literature. Supporting a student centred approach, the innovation amalgamates ePortfolios with Moodle LMS to capture learning activities and assessments in their own digital space. The project has been a collaboration between the Social Work discipline and Technology Enhanced Learning Services. Findings from our evaluation show that the use of ePortfolios is consistent with transformational learning principles whereby the software application enables critical reflection, a sense of ownership over learning and the opportunity for students to be creative. The innovation also empowers students to develop a portfolio of curated reference material along with indivdiualised evidence of knowledge that can be utilised beyond graduation for potential employers or opportunities for further study.
Entrepreneurship imperatives in higher education institutions: The case of Australian Universities
Creators: name: Nguyen, Quan
name: Maritz, Alex
name: Millemann, Jan A
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 3505
subject: Human resources and industrial relations
classificationCode: 3507
subject: Strategy, management and organisational behaviour
classificationCode: 39
subject: Education
classificationCode: 3902
subject: Education policy, sociology and philosophy
classificationCode: 3903
subject: Education systems

description: No description supplied.
Entrepreneurship imperatives in higher education institutions: The case of Australian Universities
Creators: name: Nguyen, Quan
name: Maritz, Alex
name: Millemann, Jan A
Publisher: name: La Trobe
Year: 2022

description: Earlier research has not explicitly emphasised the dynamic integration of entrepreneurship imperatives and transformation in developing the entrepreneurial university. The purpose of this research is to examine the linkage between the strategic intents articulated by universities and their corresponding level of entrepreneurship transformation. This article develops a theoretical framework to examine transformational imperatives, applying a data analytical approach to assess strategic documents using automated content analysis and complex algorithms. Australian universities were chosen for the research given the specific context of the higher education sector and the availability of strategic documents on the institutions’ websites. In the research context, the findings show that, while there are some variances with specific institutions, Australian universities in general, and several groups of universities in particular, expressed different levels of determination, ranging from moderate to moderately strong, to transform themselves into being entrepreneurial. Universities’ management can benefit from the theoretical framework developed in this research to craft strategies to further adopt entrepreneurship imperatives. Implications are also provided to inform universities, industry and government with regard to enhancing the dynamics of entrepreneurship ecosystems.
Hepatic Homeostasis of Metal Ions Following Acute Repeated Stress Exposure in Rats
Creators: name: Spiers, Jereme
name: Tan, LS
name: Anderson, ST
name: Hill, Andrew
name: Lavidis, NA
name: Chen, HJC
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3101
subject: Biochemistry and cell biology
classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3205
subject: Medical biochemistry and metabolomics
classificationCode: 3214
subject: Pharmacology and pharmaceutical sciences

description: Essential metals such as copper, iron, and zinc are cofactors in various biological processes including oxygen utilisation, cell growth, and biomolecular synthesis. The homeostasis of these essential metals is carefully controlled through a system of protein transporters involved in the uptake, storage, and secretion. Some metal ions can be transformed by processes including reduction/oxidation (redox) reactions, and correspondingly, the breakdown of metal ion homeostasis can lead to formation of reactive oxygen and nitrogen species. We have previously demonstrated rapid biochemical responses to stress involving alterations in the redox state to generate free radicals and the resultant oxidative stress. However, the effects of stress on redox-active metals including iron and copper and redox-inert zinc have not been well characterised. Therefore, this study aims to examine the changes in these essential metals following exposure to short-term repeated stress, and to further elucidate the alterations in metal homeostasis through expression analysis of different metal transporters. Outbred male Wistar rats were exposed to unrestrained (control), 1 day, or 3 days of 6 h restraint stress (n = 8 per group). After the respective stress treatment, blood and liver samples were collected for the analysis of biometal concentrations and relative gene expression of metal transporter and binding proteins. Exposure to repeated restraint stress was highly effective in causing hepatic redox imbalance. Stress was also shown to induce hepatic metal redistribution, while modulating the mRNA levels of key metal transporters. Overall, this study is the first to characterise the gene expression profile of metal homeostasis following stress and provide insight into the changes occurring prior to the onset of chronic stress conditions.
Selective Binding of Small Molecules to Vibrio cholerae DsbA Offers a Starting Point for the Design of Novel Antibacterials
Creators: name: Wang, Geqing
name: Mohanty, B
name: Williams, ML
name: Doak, BC
name: Dhouib, R
name: Totsika, M
name: McMahon, RM
name: Sharma, G
name: Zheng, D
name: Bentley, MR
name: Chin, Y Ka-Yan
name: Horne, J
name: Chalmers, DK
name: Heras, Begona
name: Scanlon, MJ
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 34
subject: Chemical sciences
subject: FOS: Chemical sciences
classificationCode: 3404
subject: Medicinal and biomolecular chemistry
classificationCode: 3405
subject: Organic chemistry

description: DsbA enzymes catalyze oxidative folding of proteins that are secreted into the periplasm of Gram-negative bacteria, and they are indispensable for the virulence of human pathogens such as Vibrio cholerae and Escherichia coli. Therefore, targeting DsbA represents an attractive approach to control bacterial virulence. X-ray crystal structures reveal that DsbA enzymes share a similar fold, however, the hydrophobic groove adjacent to the active site, which is implicated in substrate binding, is shorter and flatter in the structure of V. cholerae DsbA (VcDsbA) compared to E. coli DsbA (EcDsbA). The flat and largely featureless nature of this hydrophobic groove is challenging for the development of small molecule inhibitors. Using fragment-based screening approaches, we have identified a novel small molecule, based on the benzimidazole scaffold, that binds to the hydrophobic groove of oxidized VcDsbA with a KD of 446±10 μM. The same benzimidazole compound has ∼8-fold selectivity for VcDsbA over EcDsbA and binds to oxidized EcDsbA, with KD>3.5 mM. We generated a model of the benzimidazole complex with VcDsbA using NMR data but were unable to determine the structure of the benzimidazole bound EcDsbA using either NMR or X-ray crystallography. Therefore, a structural basis for the observed selectivity is unclear. To better understand ligand binding to these two enzymes we crystallized each of them in complex with a known ligand, the bile salt sodium taurocholate. The crystal structures show that taurocholate adopts different binding poses in complex with VcDsbA and EcDsbA, and reveal the protein-ligand interactions that stabilize the different modes of binding. This work highlights the capacity of fragment-based drug discovery to identify inhibitors of challenging protein targets. In addition, it provides a starting point for development of more potent and specific VcDsbA inhibitors that act through a novel anti-virulence mechanism.
Supplementary document for Microscopic resolution imaging of whole eye with photoacoustic microscopy - 6436433.pdf
Creators: name: Samanta, Deepayan
name: Paul, Souradip
name: Paramanick, Arijit
name: Raval, Vishal
name: Singh, Mayanglambam
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary Document
The Relationship between Cancer Caregiver Burden and Psychological Outcomes: The Moderating Role of Social Connectedness
Creators: name: Yuen, Eva
name: Wilson, Carlene
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3211
subject: Oncology and carcinogenesis

description: The present study: (a) examined the extent of caregiver burden and psychological wellbeing and (b) tested whether social connectedness moderated the association between caregiver burden and psychological symptoms in caregivers of people with cancer. The cross-sectional survey study included 189 cancer caregivers (mean age = 36.19 years, standard deviation = 11.78; 80.4% female). Data were collected on caregiver burden, social connectedness, and depression and anxiety. Moderation analysis was conducted to examine the effect of social connectedness on the relationship between caregiver burden and depression and anxiety. Caregiver burden was positively associated with depression and anxiety symptoms. Controlling for significant demographic and caregiver characteristics, the moderation model showed as perceived social connectedness increased, the relationship between caregiver burden and depression decreased (β = −0.007, se = 0.004, 95% CI: −0.014, 0.000, p = 0.05). By contrast, social connectedness did not moderate the association between caregiver burden and anxiety. Findings have implications for the management of depression in cancer caregivers. Social connectedness appears to provide a protective buffer from the negative impacts of caregiving, providing increased psychological resources to manage the burden associated with caregiving, resulting in lower depression. Research on strategies to improve caregiver wellbeing through enhancing engagement with social networks in ways that improve perceived sense of connectedness with others is warranted.