cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Effects of liraglutide compared with placebo on events of acute gallbladder or biliary disease in patients with type 2 diabetes at high risk for cardiovascular events in the LEADER randomized trial
Creators: name: Nauck, M.A.
name: Buse, J.B.
name: Saevereid, H.A.
name: Kreiner, E.
name: LEADER Publication Committee on behalf of the LEADER Trial Investigators
name: Ghorbani, M.L.M.
Publisher: name: American Diabetes Association Inc.
Year: 2019

description: Objective: To explore gallbladder- and biliary tract-related events reported for the liraglutide and placebo groups in the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) trial. Research Design and Methods: LEADER was an international, randomized, double-blind, controlled cardiovascular (CV) outcomes trial. Participants with type 2 diabetes at high risk for CV events (n = 9,340) were randomized 1:1 to receive either liraglutide (≤1.8mg daily; n = 4,668) or placebo (n = 4,672), with both groups also receiving standard care (treatment period: 3.5-5 years). Acute gallstone disease was a medical event of special interest. This post hoc analysis categorized captured events of acute gallbladder or biliary disease into four groups: uncomplicated gallbladder stones, complicated gallbladder stones, cholecystitis, and biliary obstruction. Time to first event by treatment group was analyzed using Cox regression. Results: There was an increased risk of acute gallbladder or biliary disease with liraglutide versus placebo (n = 141 of 4,668 vs. n = 88 of 4,672 patients, respectively; hazard ratio [HR] 1.60; 95% CI 1.23, 2.09; P < 0.001). Similar trends were observed for each of the four categories of gallbladder- or biliary tract-related events. Cholecystectomy was performed more frequently in liraglutide-treated patients (HR 1.56; 95% CI 1.10, 2.20; P = 0.013) but for similar proportions of the patients who experienced gallbladder- or biliary tract-related events (57% with liraglutide vs. 59% with placebo). Conclusions: Although LEADER was not specifically designed to assess acute gallbladder or biliary disease, the trial showed an increased risk of gallbladder- or biliary tract-related events with liraglutide versus placebo, which appeared to be consistent across four categories of these events. Further studies should investigate the relevant mechanisms.
Changes in serum calcitonin concentrations, incidence of medullary thyroid carcinoma, and impact of routine calcitonin concentration monitoring in the Exenatide study of Cardiovascular Event Lowering (EXSCEL)
Creators: name: Angelyn Bethel, M.
name: Gustavson, S.M.
name: Merrill, P.
name: Holman, R.R.
name: Reed, S.D.
name: Ahmadi, S.
name: Patel, R.A.
name: Gagel, R.F.
name: Iqbal, N.
name: Hernandez, A.F.
name: Buse, J.B.
name: Katona, B.G.
name: Ohman, P.
name: Li, Y.
name: Thompson, V.P.
Publisher: name: American Diabetes Association Inc.
Year: 2019

description: OBJECTIVE Increases in serum calcitonin, a tumor marker for medullary thyroid carcinoma (MTC), have been associated with glucagon-like peptide 1 receptor agonist use in some preclinical studies. We report calcitonin changes in exenatide-treated and placebo-administered participants and MTC incidence in the EXenatide Study of Cardiovascular Event Lowering (EXSCEL) and consider the impact of within-trial calcitonin monitoring. RESEARCH DESIGN AND METHODS EXSCEL participants were randomized 1:1 to once-weekly exenatide 2 mg or placebo. Serum calcitonin was measured at baseline (with trial medication discontinued if >40 ng/L) and annually thereafter (with trial medication discontinued if ‡50 ng/L). Median calcitonin concentrations were calculated at each time point, and thyroid malignancies were collected prospectively. Data regarding follow-up after an elevated calcitonin were collected retrospectively. RESULTS At baseline, 52 (30 exenatide and 22 placebo) participants had calcitonin >40 ng/L, and during follow-up an additional 23 participants (15 exenatide and 8 placebo) had calcitonin ‡50 ng/L in the intention-to-treat population. Median calcitonin concentrations were similar between treatment groups at baseline with no increase over time. Confirmed MTC occurred in three participants (2 exenatide and 1 placebo), all of whom had significantly elevated baseline calcitonin values (413, 422, and 655 ng/L). CONCLUSIONS During a median 3.2 years’ follow-up, no change in serum calcitonin was seen with exenatide therapy. The three confirmed cases of MTC all occurred in participants with markedly elevated baseline calcitonin levels, measured prior to trial medication administration. Regular calcitonin monitoring identified no additional cases of MTC, suggesting no benefit of routine calcitonin monitoring during exenatide treatment.
title: The many faces of myeloma in the head and neck
Creators: name: Duarte, Rosa
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Head and neck
subject: Oncology
subject: CT
subject: MR
subject: Education
subject: Comparative studies
subject: Cancer

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To review the spectrum of radiologic appearances of multiple myeloma in the head and neck, including solitary plasmacytoma of bone, non-osseous extramedullary plasmacytoma as well as extension of the disease using cross-sectional imaging techniques....
(101387) John Mahon
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Improved time in range and glycemic variability with sotagliflozin in combination with insulin in adults with type 1 diabetes: A pooled analysis of 24-week continuous glucose monitoring data from the IntanDEM program
Creators: name: Cariou, B.
name: Danne, T.
name: Banks, P.
name: Peters, A.L.
name: Garg, S.K.
name: Kushner, J.A.
name: Strumph, P.
name: McGuire, D.K.
name: Sawhney, S.
name: Buse, J.B.
name: Rosenstock, J.
Publisher: name: American Diabetes Association Inc.
Year: 2019

description: OBJECTIVE To evaluate effects of the dual sodium–glucose cotransporter (SGLT) 1 and SGLT2 inhibitor sotagliflozin in combination with insulin on glucose time in range (TIR) and glucose excursions, postprandial glucose (PPG), and other glycemic metrics in adults with type 1 diabetes using masked continuous glucose monitoring (CGM). RESEARCH DESIGN AND METHODS Data sets from the inTandem1 (clinical trial reg. no. NCT02384941) and inTandem2 (clinical trial reg. no. NCT02421510) double-blind randomized trials evaluating sotagliflozin versus placebo in adults with type 1 diabetes treated with optimized insulin were pooled for analyses of masked CGM data from a subset of participants in each trial. The pooled cohort included patients randomized to receive placebo (n = 93), sotagliflozin 200 mg (n = 89), or sotagliflozin 400 mg (n = 96). The primary outcome was change from baseline to week 24 in glucose TIR (3.9–10.0 mmol/L [70–180 mg/dL]). Secondary end points included time below and above the target range and 2-h PPG level assessed after a standardized mixed meal. RESULTS Mean percentage of glucose TIR/percentage time spent at <3.9 mmol/L (<70 mg/dL) during week 24 was 51.6%/5.9%, 57.8%/5.5%, and 64.2%/5.5% with placebo, sotagliflozin 200 mg, and sotagliflozin 400 mg, respectively, which corresponded to a placebo-adjusted change from a baseline of +5.4%/20.3% (P = 0.026; +1.3/20.1 h/day) for sotagliflozin 200 mg and +11.7%/20.1% (P < 0.001; +2.8/20.02 h/day) for sotagliflozin 400 mg. Placebo-adjusted PPG reductions were 1.9 6 0.7 mmol/L (35 6 13 mg/dL; P = 0.004) and 2.8 6 0.7 mmol/L (50 6 13 mg/dL; P < 0.001) with sotagliflozin 200 and 400 mg, respectively. CONCLUSIONS Combined with optimized insulin in type 1 diabetes, sotagliflozin significantly increased glucose TIR without increasing time spent at <3.9 mmol/L and reduced PPG, thereby improving glycemic control.
Assessing the association between GLP-1 receptor agonist use and diabetic retinopathy through the FDA adverse event reporting system
Creators: name: Wang, T.
name: Gower, E.W.
name: Lu, W.
name: Tang, H.
name: Stürmer, T.
name: Buse, J.B.
Publisher: name: American Diabetes Association Inc.
Year: 2019

description: Recently, the Trial to Evaluate Cardiovascular and Other Long-term Outcomes With Semaglutide in Subjects With Type 2 Diabetes (SUSTAIN-6) suggested that semaglutide may increase the risk for diabetic retinopathy (DR) adverse events (AEs) compared with placebo. Other trials of glucagon-like peptide 1 receptor agonists (GLP-1RA) showed a numerically higher incidence of DR AEs for liraglutide but not exenatide. However, these trials did not systematically assess DR. Our population-based cohort study of older U.S. adults suggested that GLP-1RA use for approximately 1 year does not increase DR risk. As current evidence on GLP-1RA–associated DR risk is still limited, we conducted a disproportionality analysis of the U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database to examine the association between GLP-1RA and DR events.
นโยบายพลังงานแสงอาทิตย์ผลิตไฟฟ้า กรณีศึกษาโครงการนำร่องพลังงานแสงอาทิตย์ ผลิตไฟฟ้าติดตั้งบนหลังคาอย่างเสรีของผู้ผลิตและผู้ใช้ไฟฟ้าประเภทครัวเรือน
Creators: name: นวลประกาย เลิศกิรวงศ์
Publisher: name: คณะบริหารการพัฒนาสิ่งแวดล้อม สถาบันบัณฑิตพัฒนบริหารศาสตร์
Year: 2019
Subjects: นโยบายพลังงานทดแทน
นโยบายพลังงานแสงอาทิตย์ผลิตไฟฟ้า
โครงการนำร่องพลังงานแสงอาทิตย์ผลิตไฟฟ้าติดตั้งบนหลังคาอย่างเสรี
การจัดทำบริการสาธารณะ
มาตรการส่งเสริมการผลิตไฟฟ้าใช้เอง

description: วารสารการจัดการสิ่งแวดล้อม, 15, 1, 4-27
title: What the pediatric lateral ventricles tell us.
Creators: name: Dominguez Piedra, Rodrigo
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Paediatric
subject: Neuroradiology brain
subject: Ultrasound
subject: MR
subject: CT
subject: Diagnostic procedure
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The pediatric brain is increasingly being studied through a wide range of technics. The lateral ventricles, which could give us extra-information, are very important to make the correct diagnosis of the subjacent cause. To study the lateral...
ถอดบทเรียนการจัดการน้ำด้วยฝายมีชีวิต บ้านนาโหนด ตำบลกำแพงเซา อำเภอเมือง จังหวัดนครศรีธรรมราช
Creators: name: รัตนา ไกรนรา
Publisher: name: คณะบริหารการพัฒนาสิ่งแวดล้อม สถาบันบัณฑิตพัฒนบริหารศาสตร์
Year: 2019
Subjects: ถอดบทเรียน
การจัดการน้ำ
ฝายมีชีวิต
นครศรีธรรมราช

description: วารสารการจัดการสิ่งแวดล้อม, 15, 1, 28-45
Assessing the association between dipeptidyl peptidase 4 inhibitor use and inflammatory bowel disease through drug adverse event reporting
Creators: name: Tang, H.
name: Lu, W.
name: Wang, T.
name: Yang, J.Y.
name: Stürmer, T.
name: Buse, J.B.
name: Li, D.
Publisher: name: American Diabetes Association Inc.
Year: 2019

description: Inflammatory bowel disease (IBD), including Crohn disease (CD) and ulcerative colitis (UC), is an autoimmune digestive system disease. A recent cohort study using the U.K. Clinical Practice Research Datalink (CPRD) involving 7,231 dipeptidyl peptidase 4 inhibitor (DPP4i) users with 49 IBD cases indicated that new use of DPP4is over a median duration of 1.6 years was associated with IBD risk in patients with type 2 diabetes compared with other noninsulin antihyperglycemic drugs (hazard ratio 1.75, 95% CI 1.22, 2.49). Current evidence regarding the effect of DPP4is on IBD risk is very limited. We thus performed a disproportionality analysis using the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) database, which contains all adverse events spontaneously reported to the Food and Drug Administration since 2004.
(101384) Sarah Ann Williams
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: ADC – MRI indicator of breast carcinoma treatment response
Creators: name: Ninčević, Josip
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Breast
subject: Genital / Reproductive system female
subject: MR
subject: MR-Functional imaging
subject: Chemotherapy
subject: Staging
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The rapid proliferation of cancer can be detected using functional MR imaging technique such as diffusion-weighted imaging (DWI) . DWI, by measuring diffusion constant of water molecules, gives informations about changes during cancer...
ปฏิบัติการของการอนุรักษ์สิ่งแวดล้อมผ่านกลไกตลาด: โครงการเรดด์พลัสในพื้นที่ป่าชุมชนบ้านหัวทุ่งอำเภอเชียงดาว จังหวัดเชียงใหม่
Creators: name: ฉัตราภรณ์ สุริวรรณ
Publisher: name: คณะบริหารการพัฒนาสิ่งแวดล้อม สถาบันบัณฑิตพัฒนบริหารศาสตร์
Year: 2019
Subjects: การปกครองชีวญาณทางด้านสิ่งแวดล้อม
การปกครองสิ่งแวดล้อมผ่านกลไกตลาดโดยหน่วยงานที่ไม่ใช่รัฐ
เรดด์พลัส
ป่าไม้

description: วารสารการจัดการสิ่งแวดล้อม, 15, 1, 46-61
title: Granulomatous Mastitis: more frequent than expected
Creators: name: Muro Paz, Victor
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Inflammation
subject: Infection
subject: Diagnostic procedure
subject: Biopsy
subject: Ultrasound
subject: MR
subject: Mammography
subject: Breast

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Inflammatory breast diseases are frequently and sometimes can mmic the clinical and radiological appearance of breast cancer(1). Granulomatous mastitis (GM) is an inflammatory breast disease, it was defined in 1972(2) by Kessler and Wolloch. GM is a...
International consensus on risk management of diabetic ketoacidosis in patients with type 1 diabetes treated with sodium-glucose cotransporter (SGLT) inhibitors
Creators: name: Ampudia-Blasco, F.J.
name: Peters, A.L.
name: Yokote, K.
name: Parkin, C.G.
name: Ferrannini, E.
name: Skyler, J.S.
name: Battelino, T.
name: Schatz, D.
name: Mathieu, C.
name: Cariou, B.
name: Tamborlane, W.V.
name: Bode, B.W.
name: Phillip, M.
name: Garg, S.
name: Pieber, T.R.
name: Alexander, C.M.
name: Kurian, M.J.
name: Henry, R.R.
name: Pettus, J.H.
name: Oron, T.
name: Buse, J.B.
name: Kushner, J.A.
name: Dandona, P.
name: Close, K.L.
name: Dutta, S.
name: Danne, T.
name: Fourlanos, S.
name: Grunberger, G.
name: Heller, S.R.
name: Rodbard, H.W.
Publisher: name: American Diabetes Association Inc.
Year: 2019

description: Sodium-glucose cotransporter (SGLT) inhibitors are new oral antidiabetes medications shown to effectively reduce glycated hemoglobin (A1C) and glycemic variability, blood pressure, and body weight without intrinsic properties to cause hypoglycemia in people with type 1 diabetes. However, recent studies, particularly in individuals with type 1 diabetes, have demonstrated increases in the absolute risk of diabetic ketoacidosis (DKA). Some cases presented with near-normal blood glucose levels or mild hyperglycemia, complicating the recognition/diagnosis of DKAand potentially delaying treatment. Several SGLT inhibitors are currently under review by the U.S. Food and Drug Administration and European regulatory agencies as adjuncts to insulin therapy in people with type 1 diabetes. Strategies must be developed and disseminated to the medical community to mitigate the associated DKA risk. This Consensus Report reviews current data regarding SGLT inhibitor use and provides recommendations to enhance the safety of SGLT inhibitors in people with type 1 diabetes.
Insights Into Patients' Experience With Type 1 Diabetes: Exit Interviews From Phase III Studies of Sotagliflozin
Creators: name: Danne, T.
name: Ervin, C.
name: Evans, E.
name: Reaney, M.
name: Lapuerta, P.
name: Joish, V.N.
name: Buse, J.B.
name: DiBenedetti, D.
name: Preblick, R.
name: Castro, R.
Publisher: name: Excerpta Medica Inc.
Year: 2019

description: Purpose: The purpose of this study was to conduct qualitative participant interviews to provide context to the meaningfulness of improvements in end points seen in 2 large-scale Phase III sotagliflozin trials in participants with type 1 diabetes. Methods: Participants were eligible for an interview if they had exited one of the clinical trials within the previous 12 months. Participants were recruited by investigators at the clinical trial sites, and interviews were conducted by independent interviewers by telephone in accordance with a semistructured interview guide. Both interviewers and participants were blinded to treatment assignment. Qualitative analysis was conducted using ATLAS-ti version 7.5, and descriptive statistics were computed and summarized. Findings: Across 3 countries, 41 participants were interviewed. Difficulty maintaining blood glucose within a desired range, described by participants as lack of blood glucose “stability,” was the most concerning symptom that they reported, wanting to see it improved during the clinical trial because it negatively impacted their physical, mental, and emotional lives. Participants who reported symptom improvement also reported a positive psychosocial impact while taking the clinical trial medication. All participants who monitored ketones described themselves as being “pretty confident” to “very confident” that they could avoid diabetic ketoacidosis by monitoring both ketone levels and understanding the physical signs and symptoms of hyperglycemia. Implications: Improvements in glucose stability and control were important to participants with type 1 diabetes, as these improvements were correlated with improvements in the participants' lives. ClinicalTrials.gov identifiers: NCT02384941; NCT02421510.
title: Imaging of the operated shoulder: a pictorial review
Creators: name: Andreani , Olivier
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Musculoskeletal joint
subject: CT
subject: MR
subject: Ultrasound
subject: Diagnostic procedure
subject: Education and training
subject: Prostheses

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The aims of this poster is to explain the normal and pathological post operative aspects of shoulder surgery, according to three steps : I) Rotator cuff and biceps surgery II) Instability surgery III) Prosthetic...
(101385) Thomas Charles Mills
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(101386) Frank Townsend
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A deep Herschel/PACS observation of CO(40-39) in NGC 1068: a search for the molecular torus
Creators: name: Janssen, A. W.
name: Bruderer, S.
name: Sturm, E.
name: Contursi, A.
name: Davies, R.
name: Hailey-Dunsheath, S.
name: Poglitsch, A.
name: Genzel, R.
name: Graciá-Carpio, J.
name: Lutz, D.
name: Tacconi, L.
name: Fischer, J.
name: González-Alfonso, E.
name: Sternberg, A.
name: Veilleux, S.
name: Verma, A.
name: Burtscher, L.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Emission from high-J CO lines in galaxies has long been proposed as a tracer of X-ray dominated regions (XDRs) produced by AGN. Of particular interest is the question of whether the obscuring torus, which is required by AGN unification models, can be observed via high-J CO cooling lines. Here we report on the analysis of a deep Herschel-PACS observation of an extremely high J CO transition (40-39) in the Seyfert 2 galaxy NGC 1068. The line was not detected, with a derived 3$σ$ upper limit of $2 \times 10^{-17}\,\text{W}\,\text{m}^{-2}$. We apply an XDR model in order to investigate whether the upper limit constrains the properties of a molecular torus in NGC 1068. The XDR model predicts the CO Spectral Line Energy Distributions for various gas densities and illuminating X-ray fluxes. In our model, the CO(40-39) upper limit is matched by gas with densities $\sim 10^{6}-10^{7}\,\text{cm}^{-3}$, located at $1.6-5\,\text{pc}$ from the AGN, with column densities of at least $10^{25}\,\text{cm}^{-2}$. At such high column densities, however, dust absorbs most of the CO(40-39) line emission at $λ= 65.69\, μ$m. Therefore, even if NGC 1068 has a molecular torus which radiates in the CO(40-39) line, the dust can attenuate the line emission to below the PACS detection limit. The upper limit is thus consistent with the existence of a molecular torus in NGC 1068. In general, we expect that the CO(40-39) is observable in only a few AGN nuclei (if at all), because of the required high gas column density, and absorption by dust.
description: 22 pages, accepted for publication in ApJ
title: Characterization of testicular adrenal rests tumors in children using ultrasonography
Creators: name: Stetca, Vlad
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Hyperplasia / Hypertrophy
subject: Congenital
subject: Diagnostic procedure
subject: Ultrasound-Colour Doppler
subject: Ultrasound
subject: Paediatric
subject: Genital / Reproductive system male

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The present project is focusing on reviewing the spectrum of ultrasonographic (US) findings in testicular adrenal rests tumors (TARTs) detected in childhood, with the main differential...
Μία ποιοτική μελέτη για τις στρατηγικές αποφάσεις διαχείρισης της μάρκας (brand management) – Το παράδειγμα της Syngenta Hellas
Creators: name: Ρισμάνης Σπύρος Ηλία
Publisher: name: Aristotle University of Thessaloniki
Year: 2022
Subjects: Διαχείριση μάρκας Στρατηγική
Καταναλωτές
Brand management
Strategy
Consumers

description: Το brand management είναι το κλειδί όχι μόνο για τις επιχειρήσεις, αλλά και για τους καταναλωτές. Από τη μία πλευρά, η μάρκα μπορεί να είναι ένα ισχυρό εργαλείο για τις εταιρείες, υποδεικνύοντας υψηλό επίπεδο ποιότητας και προσδοκίες πελατών. Μπορεί επίσης να είναι ένας παράγοντας διάκρισης από τους ανταγωνιστές, και μπορεί να βοηθήσει στη διατήρηση της ροής των κερδών. Από την άλλη πλευρά, η μάρκα μπορεί να έχει σημαντικό αντίκτυπο στους καταναλωτές ή τους πελάτες, για διάφορους λόγους. Για έναν πελάτη θα υποδεικνύει το επίπεδο δέσμευσης για την ποιότητα από τους πωλητές, γεγονός που μειώνει τον χρόνο που απαιτείται για τη λήψη μιας απόφασης αγοράς. Η εταιρική εικόνα συνήθως αναφέρεται στη χρήση κοινών στρατηγικών μαζικού μάρκετινγκ για την επικοινωνία της ταυτότητας ενός προϊόντος ή μιας υπηρεσίας. Υπάρχουν και άλλες αγορές, όπου το brand management είναι εξίσου σημαντικό με την καταναλωτική αγορά. Στην αγορά μεταξύ των επιχειρήσεων, οι εταιρείες πρέπει να είναι σε θέση να διαφοροποιούνται από τους ανταγωνιστές τους. Η οικοδόμηση μιας αξιόπιστης επωνυμίας είναι απαραίτητη για την επιτυχία στον επιχειρηματικό κόσμο
description: Brand management has a key role not only for businesses but also for consumers. On the one side, branding can be a powerful tool for companies, indicating a high level of quality and customer expectations. It can also be a differentiating factor from competitors and help keep profits flowing. On the other side, branding can have a significant impact on consumers or customers for a number of reasons. For a customer, it will indicate the level of commitment to quality by the sellers, which reduces the time required to make a purchase decision. Branding usually refers to using common mass marketing strategies to communicate a product's or service's identity. In other markets, brand management is just as important as in the consumer market. In the business-to-business market, companies must be able to differentiate themselves from their competitors. The survival of the organism and the individual are at risk in this situation. Building a trusted brand is essential to success in the business world
title: Intra-patient variability in background parenchymal enhancement at very-short-interval follow-up breast MRI studies
Creators: name: Paravasthu, Dhivya
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Education
subject: MR
subject: Breast
subject: Biological effects

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To quantify intra-patient variability in the magnetic resonance imaging (MRI) background parenchymal enhancement (BPE) and its relationship to the timing of menstrual cycle and breast density in a cohort of premenopausal...
Bringing closure: towards achieving a better understanding of Israel
Creators: name: Zimmet, P.
name: Skyler, J.S.
name: Alberti, K.G.
name: Rosenstock, J.
name: Hirsch, I.B.
name: Schatz, D.
name: Kahn, S.
name: Buse, J.B.
name: Leroith, D.
name: Atkinson, M.
Publisher: name: Lancet Publishing Group
Year: 2019

description: We wholeheartedly endorse Richard Horton’s timely Comment, in which he addresses the global rise of anti-Semitism particularly evident in Europe and the USA. Horton stresses the need to educate medical students and health-care professionals of the evil and disastrous consequences of ignoring the historical reality of the Holocaust. It will remind the world, 75 years on, that the call Never Again remains highly relevant!
title: Imaging of cerebral venous thrombosis: key issues and pitfalls
Creators: name: Dekimpe, Chloé
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Ischaemia / Infarction
subject: Embolism / Thrombosis
subject: Acute
subject: Diagnostic procedure
subject: MR-Diffusion/Perfusion
subject: MR-Angiography
subject: CT-Angiography
subject: Neuroradiology brain
subject: Emergency

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Know the diagnostic strategy for suspectedcerebral venous thrombosis (CVT) and pitfalls for the...
Evidence supports prediabetes treatment
Creators: name: Herman, W.H.
name: Barrett, E.J.
name: Grant, R.W.
name: Neumiller, J.J.
name: Hirsch, I.B.
name: Wysham, C.H.
name: Inzucchi, S.E.
name: Kalyani, R.R.
name: Buse, J.B.
name: Fonseca, V.A.
Publisher: name: American Association for the Advancement of Science
Year: 2019

description: In his News Feature on prediabetes (“Dubious diagnosis,” 8 March, p. 1026), C. Piller asserts that prediabetes diagnoses and treatment may be ineffective and sullied by conflicts of interest. As current and former chairs of the American Diabetes Association’s (ADA’s) Professional Practice Committee [the group that reviews and updates the Standards of Medical Care in Diabetes (Standards) each year], we disagree. Prediabetes is a useful term to convey future risk of diabetes, and recommendations for diabetes prevention are based on best current evidence.
Measuring temporal turnover in ecological communities
Creators: name: Shimadzu, Hideyasu
name: Dornelas, Maria
name: Magurran, Anne E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantitative Methods (q-bio.QM)
subject: Applications (stat.AP)
subject: FOS: Biological sciences
subject: FOS: Computer and information sciences

description: Range migrations in response to climate change, invasive species and the emergence of novel ecosystems highlight the importance of temporal turnover in community composition as a fundamental part of global change in the Anthropocene. Temporal turnover is usually quantified using a variety of metrics initially developed to capture spatial change. However, temporal turnover is the consequence of unidirectional community dynamics resulting from processes such as population growth, colonisation and local extinction. Here, we develop a framework based on community dynamics, and propose a new temporal turnover measure. A simulation study and an analysis of an estuarine fish community both clearly demonstrate that our proposed turnover measure offers additional insights relative to spatial-context-based metrics. Our approach reveals whether community turnover is due to shifts in community composition or in community abundance, and identifies the species and/or environmental factors that are responsible for any change.
Characteristics and Delivery of Diabetes Shared Medical Appointments in North Carolina
Creators: name: Buse, J.B.
name: Drake, C.
name: Shea, C.M.
name: Edelman, D.
name: Spratt, S.
name: Kirk, J.K.
name: Young, L.A.
name: Kahkoska, A.R.
Publisher: name: NLM (Medline)
Year: 2019

description: BACKGROUND Successful diabetes care requires patient engagement and health self-management. Diabetes shared medical appointments (SMAs) are an evidence-based approach that enables peer support, diabetes group education, and medication management to improve outcomes. The purpose of this study is to learn how diabetes SMAs are being delivered in North Carolina, including the characteristics of diabetes SMAs across the state.METHOD Twelve health systems in the state of North Carolina were contacted to explore clinical workflow and intervention characteristics with a member of the SMA care delivery team. Surveys were used to assess intervention characteristics and delivery.RESULTS Diabetes SMAs were offered in 10 clinics in 5 of the 12 health systems contacted with considerable heterogeneity across sites. The majority of SMAs were open cohorts (80%), offered monthly (60%) for 1.5 hours (60%). SMAs included a mean of 7.5 ± 3.4 patients with a maximum of 11.2 ± 2.7 patients. Survey data revealed barriers (cost-sharing and provider buy-in) to, and facilitators (leadership support and clinical champions) of, clinical adoption and sustained implementation.LIMITATIONS External validity is limited due to the small sample size and geographic clustering.CONCLUSION There is significant heterogeneity in the delivery and characteristics of diabetes SMAs in North Carolina with only modest uptake across the health systems. Further research to determine best practices and effectiveness in diverse, real-world clinical settings is required to inform implementation and dissemination efforts.
(101382) William Robert Lucas
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Initial injectable therapy in type 2 diabetes: Key considerations when choosing between glucagon-like peptide 1 receptor agonists and insulin
Creators: name: Alexopoulos, A.-S.
name: Buse, J.B.
Publisher: name: W.B. Saunders
Year: 2019

description: Managing type 2 diabetes is complex and necessitates careful consideration of patient factors such as engagement in self-care, comorbidities and costs. Since type 2 diabetes is a progressive disease, many patients will require injectable agents, usually insulin. Recent ADA-EASD guidelines recommend glucagon-like peptide 1 receptor agonists (GLP-1 RAs) as first injectable therapy in most cases. The basis for this recommendation is the similar glycemic efficacy of GLP-1 RAs and insulin, but with GLP-1 RAs promoting weight loss instead of weight gain, at lower hypoglycemia risk, and with cardiovascular benefits in patients with pre-existing cardiovascular disease. GLP-1 RAs also reduce burden of glucose self-monitoring. However, tolerability and costs are important considerations, and notably, rates of drug discontinuation are often higher for GLP-1 RAs than basal insulin. To minimize risk of gastrointestinal symptoms patients should be started on lowest doses of GLP-1 RAs and up-titrated slowly. Overall healthcare costs may be lower with GLP-1 RAs compared to insulin. Though patient-level costs may still be prohibitive, GLP-1 RAs can replace 50–80 units of insulin daily and reduce costs associated with glucose self-monitoring. Decisions regarding initiating injectable therapy should be individualized. This review provides a framework to guide decision-making in the real-world setting.
title: Entering the third dimension: How 3D-Printing can enhance the understanding of pathologies - An educational case series
Creators: name: Brantner, Philipp
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Education and training
subject: Computer Applications-3D
subject: Image manipulation / Reconstruction
subject: Computer applications

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To recognize 3D-Printing as a valuable addition to the radiological report To understand technical and software requirements To comprehend the process turning a volumetrical dataset into a 3D-Print To name several specialties that might profit from...
title: Phakomatosis:Diagnostic Imaging of Neurological and Extra-neurological manifestation
Creators: name: Musa, Eiman
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Congenital
subject: Computer Applications-Detection, diagnosis
subject: Ultrasound
subject: MR
subject: CT
subject: CNS
subject: Bones
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: After completing this educational activity, the reader will be able to: Distinguish between characteristic neuroimaging features of different subtypes of phakomatosis and correlate with their clinical presentations. Describe various...
(101379) Mary Thomas
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Quantifying the consistency of scientific databases
Creators: name: Šubelj, Lovro
name: Bajec, Marko
name: Boshkoska, Biljana Mileva
name: Kastrin, Andrej
name: Levnajić, Zoran
Publisher: name: arXiv
Year: 2015
Subjects: subject: Digital Libraries (cs.DL)
subject: Social and Information Networks (cs.SI)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: Science is a social process with far-reaching impact on our modern society. In the recent years, for the first time we are able to scientifically study the science itself. This is enabled by massive amounts of data on scientific publications that is increasingly becoming available. The data is contained in several databases such as Web of Science or PubMed, maintained by various public and private entities. Unfortunately, these databases are not always consistent, which considerably hinders this study. Relying on the powerful framework of complex networks, we conduct a systematic analysis of the consistency among six major scientific databases. We found that identifying a single "best" database is far from easy. Nevertheless, our results indicate appreciable differences in mutual consistency of different databases, which we interpret as recipes for future bibliometric studies.
description: 20 pages, 5 figures, 4 tables
The Bohr--Pál Theorem and the Sobolev Space $W_2^{1/2}$
Creators: name: Lebedev, Vladimir
Publisher: name: arXiv
Year: 2015
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics
subject: 42A16

description: The well-known Bohr--Pál theorem asserts that for every continuous real-valued function $f$ on the circle $\mathbb T$ there exists a change of variable, i.e., a homeomorphism $h$ of $\mathbb T$ onto itself, such that the Fourier series of the superposition $f\circ h$ converges uniformly. Subsequent improvements of this result imply that actually there exists a homeomorphism that brings $f$ into the Sobolev space $W_2^{1/2}(\mathbb T)$. This refined version of the Bohr--Pál theorem does not extend to complex-valued functions. We show that if $α<1/2$, then there exists a complex-valued $f$ that satisfies the Lipschitz condition of order $α$ and at the same time has the property that $f\circ h\notin W_2^{1/2}(\mathbb T)$ for every homeomorphism $h$ of $\mathbb T$.
A genetic locus on chromosome 2q24 predicting peripheral neuropathy risk in type 2 diabetes: Results from the ACCORD and BARI 2D studies
Creators: name: Shah, H.
name: Doria, A.
name: Wagner, M.J.
name: Mychaleckyj, J.C.
name: Ray, P.R.
name: Lenzini, P.A.
name: Campbell, H.
name: Motsinger-Reif, A.A.
name: Pop-Busui, R.
name: Tang, Y.
name: Buse, J.B.
name: Cresci, S.
name: Price, T.J.
name: Perkins, B.A.
name: Callaghan, B.
Publisher: name: American Diabetes Association Inc.
Year: 2019

description: Genetic factors have been postulated to be involved in the etiology of diabetic peripheral neuropathy (DPN), but their identity remains mostly unknown. The aim of this study was to conduct a systematic search for genetic variants influencing DPN risk using two wellcharacterized cohorts. A genome-wide association study (GWAS) testing 6.8 million single nucleotide polymorphisms was conducted among participants of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) clinical trial. Included were 4,384 white case patients with type 2 diabetes (T2D) and prevalent or incident DPN (defined as a Michigan Neuropathy Screening Instrument clinical examination score >2.0) and 784 white control subjects with T2D and no evidence of DPN at baseline or during follow-up. Replication of significant loci was sought among white subjects with T2D (791 DPN-positive case subjects and 158 DPNnegative control subjects) from the Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes (BARI 2D) trial. Association between significant variants and gene expression in peripheral nerves was evaluated in the Genotype-Tissue Expression (GTEx) database. A cluster of 28 SNPs on chromosome 2q24 reached GWAS significance (P < 5×10-8) in ACCORD. The minor allele of the lead SNP (rs13417783,minor allele frequency = 0.14) decreased DPN odds by 36%(odds ratio [OR] 0.64, 95% CI 0.55-0.74, P = 1.9×10-9). This effect was not influenced by ACCORD treatment assignments (P for interaction = 0.6) or mediated by an association with known DPN risk factors. This locus was successfully validated in BARI 2D (OR 0.57, 95%CI 0.42-0.80,P=9×10-4; summary P=7.9×10-12). In GTEx, the minor, protective allele at this locus was associated with higher tibial nerve expression of an adjacent gene (SCN2A) coding for human voltage-gated sodium channel NaV1.2 (P = 9×10-4). To conclude, we have identified and successfully validated a previously unknown locus with a powerful protective effect on the development of DPN in T2D. These results may provide novel insights into DPN pathogenesis and point to a potential target for novel interventions.
title: The utility of static fluid magnetic resonance urography in differentiation of renal parenchymal cyst and calyceal diverticulum in children
Creators: name: Sahin, Hilal
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Kidney
subject: Paediatric
subject: MR
subject: Ultrasound
subject: Comparative studies
subject: Diagnostic procedure
subject: Diverticula

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To assess the role of static-fluid magnetic resonance (MR) urography in differentiation of renal parenchymal cysts and calyceal diverticulum in comparison with detailed renal ultrasonography...
การสำรวจแหล่งกำเนิดสารปนเปื้อน และประเมินศักยภาพด้านคุณภาพน้ำ แม่น้ำเจ้าพระยาในหน้าแล้ง
Creators: name: สิตางศุ์ พิลัยหล้า
Publisher: name: คณะบริหารการพัฒนาสิ่งแวดล้อม สถาบันบัณฑิตพัฒนบริหารศาสตร์
Year: 2019
Subjects: แม่น้ำเจ้าพระยา
แหล่งกำเนิดสารปนเปื้อน
คุณภาพน้ำ
น้ำเสียชุมชน
ค่าความสกปรกอินทรีย์

description: วารสารการจัดการสิ่งแวดล้อม, 15, 1, 62-83
Effect of liraglutide on cardiovascular outcomes in elderly patients: A post hoc analysis of a randomized controlled trial
Creators: name: Roginski Rea, R.
name: Jodar-Gimeno, E.
name: Nauck, M.A.
name: Pratley, R.
name: Rasmussen, S.
name: Franek, E.
name: Buse, J.B.
name: Kerr Saraiva, J.F.
name: Bain, S.C.
name: Gilbert, M.P.
Publisher: name: American College of Physicians
Year: 2019

description: Background: Comorbidities and complications associ-ated with type 2 diabetes mellitus (T2DM) increase with age, making treatment of elderly persons with this condition chal-lenging. Clinical data on the effect of antihyperglycemic treat-ment on cardiovascular (CV) events in elderly persons are limited (1). The U.S. Food and Drug Administration and Euro-pean Medicines Agency recommend collecting comprehen-sive data on elderly patients with diabetes, particularly those aged 75 years or older, to inform appropriate treatment of this growing population
Pengembangan Budidaya Ikan Misbahul Munir Farm Melalui Digital Marketing Oleh Mahasiswa Kuliah Kerja Nyata Universitas Riau 2024 Di Desa Tanjung
Creators: name: Henni Noviasari, Fendri Fendri, Hanifa Sari, Alfiq Resya Pratama, Putri Lestari, Eka Fajri Jayanti, Annisa Utari, Rindiani Rindiani, Ilham Wahyudi, Erisa Putri Dwi Siska, Adamsyah Husniawan
Publisher: name: Zenodo
Year: 2024

description: Pengabdian ini membahas pengembangan Usaha Mikro, Kecil, dan Menengah (UMKM) Misbahul Munir Farm di Desa Tanjung, Kepulauan Meranti, Desa Tanjung memiliki potensi penduduknya bekerja sebagai wiraswasta dan petani. Salah satu wirausaha yang ada didesa Tanjung yaitu Budidaya ikan tawar. Misbahul Munir Farm, yang didirikan oleh Pak Munir pada tahun 2010, telah berkembang menjadi salah satu sentra budidaya ikan air tawar terkemuka di wilayah tersebut. Dalam upaya meningkatkan visibilitas dan daya saing usaha, mahasiswa Kuliah Kerja Nyata (KKN) 2024 berkolaborasi dengan Pak Munir untuk membuat Google Maps (GMAPS) dan memasang spanduk sebagai bagian dari strategi pemasaran.
มูลค่าความเสียหายทางเศรษฐกิจ ผลจาก ความเสื่อมโทรมของทรัพยากรต้นน้ำของเขื่อนภูมิพล : หลักการและเหตุผลสำหรับการคุ้มครองธรรมชาติในพื้นที่ภาคเหนือของประเทศไทย
Creators: name: นิพนธ์พันธุ์ ศศิธร
Publisher: name: คณะบริหารการพัฒนาสิ่งแวดล้อม สถาบันบัณฑิตพัฒนบริหารศาสตร์
Year: 2019
Subjects: ทรัพยากรน้ำ
มูลค่าทางเศรษฐกิจ
เขื่อนภูมิพล
การลงทุนเพื่อคุ้มครองธรรมชาติ

description: วารสารการจัดการสิ่งแวดล้อม, 15, 1, 84-103
เมื่อแหล่งน้ำกลายเป็นสีเขียว: การจัดการฟอสฟอรัสและการฟื้นฟูแหล่งน้ำจืด
Creators: name: อนุชนรา ตาลกุล คัสเธอร์
Publisher: name: คณะบริหารการพัฒนาสิ่งแวดล้อม สถาบันบัณฑิตพัฒนบริหารศาสตร์
Year: 2019
Subjects: ยูโทฟิเคชั่น
ไซยาโนแบคทีเรีย
การจัดการฟอสฟอรัส
การใส่สารส้ม
บึงประดิษฐ์แบบลอยน้ำ

description: วารสารการจัดการสิ่งแวดล้อม, 15, 1, 104-121