cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Structure and sequence elements of the CR4/5 domain of medaka telomerase RNA important for telomerase function
Creators: name: Kim, Nak Kyoon
name: Zhang, Qi
name: Feigon, Juli
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Telomerase is a unique reverse transcriptase that maintains the 3′ ends of eukaryotic chromosomes by adding tandem telomeric repeats. The RNA subunit (TR) of vertebrate telomerase provides a template for reverse transcription, contained within the conserved template/pseudoknot domain, and a conserved regions 4 and 5 (CR4/5) domain, all essential for catalytic activity. We report the nuclear magnetic resonance (NMR) solution structure of the full-length CR4/5 domain from the teleost fish medaka (Oryzias latipes). Three helices emanate from a structured internal loop, forming a Y-shaped structure, where helix P6 stacks on P5 and helix P6.1 points away from P6. The relative orientations of the three helices are Mg2+ dependent and dynamic. Although the three-way junction is structured and has unexpected base pairs, telomerase activity assays with nucleotide substitutions and deletions in CR4/5 indicate that none of these are essential for activity. The results suggest that the junction is likely to change conformation in complex with telomerase reverse transcriptase and that it provides a flexible scaffold that allows P6 and P6.1 to correctly fold and interact with telomerase reverse transcriptase.
Simple-current algebra constructions of 2+1D topological orders
Creators: name: Schoutens, Kareljan
name: Wen, Xiao-Gang
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Self-consistent (non-)abelian statistics in 2+1D are classified by modular tensor categories (MTC). In recent works, a simplified axiomatic approach to MTCs, based on fusion coefficients $N^{ij}_k$ and spins $s_i$, was proposed. A numerical search based on these axioms led to a list of possible (non-)abelian statistics, with rank up to $N=7$. However, there is no guarantee that all solutions to the simplified axioms are consistent and can be realised by bosonic physical systems. In this paper, we use simple-current algebra to address this issue. We explicitly construct many-body wave functions, aiming to realize the entries in the list (\ie realize their fusion coefficients $N^{ij}_k$ and spins $s_i$). We find that all entries can be constructed by simple-current algebra plus conjugation under time reversal symmetry. This supports the conjecture that simple-current algebra is a general approach that allows us to construct all (non-)abelian statistics in 2+1D. It also suggests that the simplified theory based on $(N^{ij}_k,s_i)$ is a classifying theory at least for simple bosonic 2+1D topological orders (up to invertible topological orders).
description: 19 pages, revtex4; v2 has small corrections and extended introduction
Effects of nutritive solution electrical conductivity and plant density on growth, yield and quality of sweet basil grown in gullies by subirrigation
Creators: name: Morano, G.
name: Amalfitano, C.
name: Sellitto, M.
name: Cuciniello, A.
name: Maiello, R.
name: Caruso, G.
Publisher: name: Advances in Horticultural Science
Year: 2017

description: The increasing demand for basil in the last decade has arisen from consumer tendency towards high nourishing produce. Soilless growing of this crop is a current farm strategy and the quality targets are affected by nutritive solution as well as by plants density per pot. Research was carried out with the aim of assessing plant growth, yield and leaves quality of basil (Ocimum basilicum L., cv. Gecom FT) grown in pots (peat-lapil) and fed by subirrigation inside plastic gullies, under a heated greenhouse. Comparisons were made of four electrical conductivities (EC: 2.2, 2.5, 2.8, 3.1 mS·cm-1) in factorial combination with four plant densities (9, 12, 15, 18 plants per pot) and a split plot design was arranged with three replicates. The 2.8 mS.cm-1 EC resulted in the best yield, growth indexes and biometrical parameters values. Water absorption was highest under the 2.8 mS.cm-1 EC, whereas the highest nutrient consumptions as well as the best quality indicators and chemical composition corresponded to the 2.8 to 3.1 mS.cm-1 EC range. The 12 plants per pot density gave the best results, in terms of yield, growth indexes and biometrical parameters, also showing the highest plant water and nutrient uptakes. The leaves quality attributes and chemical composition always displayed decreasing trends as a function of the plant density increase, the highest values corresponding to 9 and 12 plants per pot; only the nitrates concentration showed an opposite trend compared to the other nutrients. In conclusion, the 2.8 mS.cm-1 nutritive solution and the 12 plants per pot density resulted in the best yield and leaves quality. Further enhancement of both experimental factors level even caused the reduction of water and nutrient efficiency use.
description: Advances in Horticultural Science, Vol 31 No 1 (2017)
Magnetic-dipolar-mode Fano resonances for microwave spectroscopy of high absorption matter
Creators: name: Vaisman, G.
name: Kamenetskii, E. O.
name: Shavit, R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Study of interaction between high absorption matter and microwave radiated energy is a subject of great importance. Especially, this concerns microwave spectroscopic characterization of biological liquids. Use of effective testing methods to obtain information about physical properties of different liquids on the molecular level is one of the most important problems in biophysics. However, the standard methods based on the microwave resonant techniques are not sufficiently suitable for biological liquids because the resonance peak in a resonator with high-loss liquids is so broad that the material parameters cannot be measured correctly. Although molecular vibrations of biomolecules may have microwave frequencies, it is not thought that such resonant coupling is significant due to their low energy compared with thermal energy and the strongly dampening aqueous environment. This paper presents an innovative microwave sensing technique for different types of lossy materials, including biological liquids. The technique is based on the combination of the microwave perturbation method and the Fano-resonance effects observed recently in microwave structures with embedded magnetic-dipolar quantum dots. When frequency of the magnetic-dipolar-mode (MDM) resonance is not equal to the cavity resonance frequency, one gets Fano transmission intensity. With tuning, by a bias magnetic field, the MDM resonance frequency to the cavity resonance frequency, one observes a Lorentz line shape. Use of an extremely narrow Lorentzian peak allows exact probing the resonant frequency of a cavity loaded by a high-lossy-material sample. For different kinds of samples, one has different frequencies of Lorentzian peaks. This gives a picture for precise spectroscopic characterization of high absorption matter in microwaves.
Vicinal: a method for the determination of ncRNA ends using chimeric reads from RNA-seq experiments
Creators: name: Lu, Zhipeng
name: Matera, A. Gregory
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Non-coding (nc)RNAs are important structural and regulatory molecules. Accurate determination of the primary sequence and secondary structure of ncRNAs is important for understanding their functions. During cDNA synthesis, RNA 3′ end stem-loops can self-prime reverse transcription, creating RNA–cDNA chimeras. We found that chimeric RNA–cDNA fragments can also be detected at 5′ end stem-loops, although at much lower frequency. Using the Gubler–Hoffman method, both types of chimeric fragments can be converted to cDNA during library construction, and they are readily detectable in high-throughput RNA sequencing (RNA-seq) experiments. Here, we show that these chimeric reads contain valuable information about the boundaries of ncRNAs. We developed a bioinformatic method, called Vicinal, to precisely map the ends of numerous fruitfly, mouse and human ncRNAs. Using this method, we analyzed chimeric reads from over 100 RNA-seq datasets, the results of which we make available for users to find RNAs of interest. In summary, we show that Vicinal is a useful tool for determination of the precise boundaries of uncharacterized ncRNAs, facilitating further structure/function studies.
title: Pegelabhängigkeit des Overshoots in statistischen und reproduzierbaren Rauschmaskierern
Creators: name: Klitzing, Regine von
name: Kohlrausch, Armin
Publisher: name: Deutsche Gesellschaft für Akustik e.V.
Year: 2023

description: Es wurden Messungen zur zeitlichen Struktur der Simultanverdeckung in statistischen und reproduzierbaren Rauschmaskierern vorgestellt. Bei den Experimenten in frozen noise wurde die Wechselwirkung zwischen Testsignal und Feinstruktur des Maskierers berücksichtigt. Die Mithörschwellen zeigen ein Abhängigkeit von der Anfangsphase des Testtones. Daher wurden die Messungen zum Overshootphänomen in frozen noise für die beiden Testtonphasen durchgeführt, bei denen die Schwellen in den Experimenten zur Phasenabhängigkeit ihren maximalem bzw. minimalen Wert annehmen. Ein Zusammenhang zwischen dem Einfluß der Phase auf die Mithörschwellen und der Größe des Overshoot tritt besonders deutlich bei einem Rauschpegel von 50 dB SPL auf. Aufgrund des großen Signal-Rauschverhältnisses zu Maskiererbeginn ist dort die Phasenabhängigkeit verglichen mit den Resultaten am Maskiererende sehr gering. Die Ergebnisse zeigen, daß der Overshoot in frozen noise sowohl von der Startphase des Testtones als auch vom Rauschpegel abhängt. Die Overshootwerte, die für die beiden Phasen in frozen noise ermittelt wurden, bilden i.a. die obere und untere Begrenzung für die Werte in running noise. Die Möglichkeit zur Auswertung der Maskiererfeinstruktur führt demnach nicht generell zu einer Verringerung des Overshoots.
Flower anatomy related to blooming development of Berberis microphylla G. Forst Berberida microphylla G. Forst (berberidaceae)
Creators: name: Radice, S.
name: Arena, M.
Publisher: name: Advances in Horticultural Science
Year: 2017

description: Berberis microphylla G. Forst. is a Patagonian native shrub commonly named “calafate”, which has a growing economic potential due to its dark blue berries that are consumed fresh, as jams and preserves, and are used for the production of soft drinks and ice cream. Moreover, the fruits have a high content of carbohydrates, phenols and antioxidants. The objective of this work was to show the changes observed in the flower from the emergence in relation to the floral phases and the importance that they have on pollination and fertilization. During the anthesis, the nectar is excreted inside and outside of the petal through the epidermis of the secretory tissue. The epidermis of the stigma is papillae with cells of greater length in the periphery of this structure simulating an additional ring. Secretory tissue is also present on the area of the fusion carpel. During anthesis, the epidermis glands of the stigma showed active secretion and these conditions favor pollen grain germination. Germinated pollen grains were observed after 12 hours of pollination and ten days later the pollen tube reached the ovule area. Pollen tube grew surrounded the ovules and probably some of them already accomplished the fertilization.
description: Advances in Horticultural Science, Vol 31 No 1 (2017)
Additional file 1 of In-silico activity prediction and docking studies of some flavonol derivatives as anti-prostate cancer agents based on Monte Carlo optimization
Creators: name: Tajiani, Faezeh
name: Ahmadi, Shahin
name: Lotfi, Shahram
name: Kumar, Parvin
name: Almasirad, Ali
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
classificationCode: 80699
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Plant Biology
subject: Computational Biology

description: Additional file 1: Table S1. Chemical structures of flavonol derivatives and IC50 values against PC-3 prostate cancer cells.
Twisted generalized Weyl algebras and primitive quotients of enveloping algebras
Creators: name: Hartwig, Jonas T.
name: Serganova, Vera
Publisher: name: arXiv
Year: 2015
Subjects: subject: Representation Theory (math.RT)
subject: Rings and Algebras (math.RA)
subject: FOS: Mathematics

description: To each multiquiver $Γ$ we attach a solution to the consistency equations associated to twisted generalized Weyl (TGW) algebras. This generalizes several previously obtained solutions in the literature. We show that the corresponding algebras $\mathcal{A}(Γ)$ carry a canonical representation by differential operators and that $\mathcal{A}(Γ)$ is universal among all TGW algebras with such a representation. We also find explicit conditions in terms of $Γ$ for when this representation is faithful or locally surjective. By forgetting some of the structure of $Γ$ one obtains a Dynkin diagram, $D(Γ)$. We show that the generalized Cartan matrix of $\mathcal{A}(Γ)$ coincides with the one corresponding to $D(Γ)$ and that $\mathcal{A}(Γ)$ contains graded homomorphic images of the enveloping algebra of the positive and negative part of the corresponding Kac-Moody algebra. Finally, we show that a primitive quotient $U/J$ of the enveloping algebra of a finite-dimensional simple Lie algebra over an algebraically closed field of characteristic zero is graded isomorphic to a TGW algebra if and only if $J$ is the annihilator of a completely pointed (multiplicity-free) simple weight module. The infinite-dimensional primitive quotients in types $A$ and $C$ are closely related to $\mathcal{A}(Γ)$ for specific $Γ$. We also prove one result in the affine case.
description: 38 pages
Allele-specific copy-number discovery from whole-genome and whole-exome sequencing
Creators: name: Wang, Weibo
name: Wang, Wei
name: Sun, Wei
name: Crowley, James J.
name: Szatkiewicz, Jin P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Copy-number variants (CNVs) are a major form of genetic variation and a risk factor for various human diseases, so it is crucial to accurately detect and characterize them. It is conceivable that allele-specific reads from high-throughput sequencing data could be leveraged to both enhance CNV detection and produce allele-specific copy number (ASCN) calls. Although statistical methods have been developed to detect CNVs using whole-genome sequence (WGS) and/or whole-exome sequence (WES) data, information from allele-specific read counts has not yet been adequately exploited. In this paper, we develop an integrated method, called AS-GENSENG, which incorporates allele-specific read counts in CNV detection and estimates ASCN using either WGS or WES data. To evaluate the performance of AS-GENSENG, we conducted extensive simulations, generated empirical data using existing WGS and WES data sets and validated predicted CNVs using an independent methodology. We conclude that AS-GENSENG not only predicts accurate ASCN calls but also improves the accuracy of total copy number calls, owing to its unique ability to exploit information from both total and allele-specific read counts while accounting for various experimental biases in sequence data. Our novel, user-friendly and computationally efficient method and a complete analytic protocol is freely available at https://sourceforge.net/projects/asgenseng/.
Resonant inverse Faraday effect in nanorings
Creators: name: Koshelev, K. L.
name: Kachorovskii, V. Yu.
name: Titov, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: A circularly polarized light can induce a dissipationless dc current in a quantum nanoring which is responsible for a resonant helicity-driven contribution to magnetic moment. This current is not suppressed by thermal averaging despite its quantum nature. We refer to this phenomenon as the quantum resonant inverse Faraday effect. For weak electromagnetic field, when the characteristic coupling energy is small compared to the energy level spacing, we predict narrow resonances in the circulating current and, consequently, in the magnetic moment of the ring. For strong fields, the resonances merge into a wide peak with a width determined by the spectral curvature. We further demonstrate that weak short-range disorder splits the resonances and induces additional particularly sharp and high resonant peaks in dc current and magnetization. In contrast, long-range disorder leads to a chaotic behavior of the system in the vicinity of the separatrix that divides the phase space of the system into regions with dynamically localized and delocalized states.
description: 17 pages, 10 figures
Development of pollination and in vitro germination techniques to improve the hybridization in Hydrangea spp.
Creators: name: Venturieri, G.A.
name: Nesi, B.
name: Lazzereschi, S.
name: Pecchioli, S.
name: Burchi, G.
Publisher: name: Advances in Horticultural Science
Year: 2017

description: Hydrangea is a genus of ornamental plants which is gaining new markets mainly as a fresh or dried cut flower, but it is also important as a pot plant and for landscaping. To expand its market, new hybrids should be developed. To increase the hybridization efficiency, some techniques were developed and tested: i) evaluation of two pollination systems; ii) comparison among fruit-cut systems before in vitro cultivation to develop embryos and to allow the growth of new genotypes; iii) evaluation of seed disinfection systems for in vitro germination; iv) sowing systems using seeds and fruits from stocks cultivated in two environments. To increase inter- and intra-specific hybridization, pollination by dispersion of previously collected pollen on the top of a corymb by a brush was more effective than pollination using the corymb itself as a brush. A longitudinal cut system can be considered the best treatment to be applied on fruits before in vitro cultivation to allow growth of seedlings. Sterilization of seeds can be done by immersion in a solution of commercial bleach for 5 minutes on MS culture medium with PPM®. When stocks are cultivated in greenhouses, in vitro contamination is lower and seeds have a better rate of germination. The results of these experiments were applied in a breeding program on Hydrangea using sexual crosses.
description: Advances in Horticultural Science, Vol 31 No 1 (2017)
title: Επιδημιολογική μελέτη του βάρους γέννησης κατά ηλικία κύησης των ζώντων νεογνών στην Ελλάδα: Δημιουργία καμπυλών αναφοράς και επιπτώσεις στις πολιτικές δημόσιας υγείας
title: Epidemiological study of Birthweight by Gestational age of liveborn neonates in Greece: Development of reference centile charts and implications for Public Health policies.
titleType: AlternativeTitle
Creators: name: Τσαγκάρη, Ανδριανή
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2020
Subjects: Birthweight centiles
Gestational Age
Βάρος γέννησης
Ηλικία κύησης
Eπιπτώσεις
Kαμπύλες αναφοράς
Reference Curves.
Consequences

description: Εισαγωγή: Το αποκλίνον βάρος γέννησης για την ηλικία κύησης έχει συνδεθεί με αυξημένη νοσηρότητα και θνησιμότητα στην περιγεννητική περίοδο και με μεγαλύτερη συχνότητα προβλημάτων υγείας στην ενήλικη ζωή. Η παρακολούθηση της ενδομήτριας ανάπτυξης των εμβρύων γίνεται με βάση διαγράμματα, ευρέως γνωστά ως καμπύλες εκατοστημορίων βάρους κατά ηλικία κύησης. Υπάρχουν πολλοί διαφορετικοί τύποι καμπυλών, μέχρι σήμερα όμως δεν υπάρχει ομοφωνία ως προς τον τύπο που θα πρέπει να χρησιμοποιείται διεθνώς. Οι περισσότερες χώρες έχουν δημιουργήσει καμπύλες αναφοράς για τον πληθυσμό τους βασιζόμενες σε συγχρονικές μελέτες καταγραφής του βάρους γέννησης κατά ηλικία κύησης. Από όσο είμαστε σε θέση να γνωρίζουμε, για την Ελλάδα δεν έχουν δημιουργηθεί έως σήμερα τέτοιες καμπύλες. Σκοπός: Η δημιουργία πληθυσμιακών καμπυλών αναφοράς βάρους γέννησης κατά ηλικία κύησης και φύλο ζώντων νεογνών από μονήρεις κυήσεις στην Ελλάδα και η ανάδειξη των επιπτώσεων απόκλισης από το κανονικό βάρος γέννησης για την ηλικία κύησης, για τη Δημόσια Υγεία. Μέθοδος: Ελήφθησαν από την Ελληνική Στατιστική Υπηρεσία δεδομένα βάρους γέννησης κατά ηλικία κύησης και φύλο όλων των ζώντων νεογνών από μονήρεις κυήσεις που έλαβαν χώρα στην Ελλάδα τα έτη 2011-2017. Με βάση αυτά, υπολογίστηκαν η 3η, 5η,10η, 25η, 50η, 75η, 90η, 95η και 97η εκατοστιαία θέση βάρους γέννησης για κάθε εβδομάδα κύησης από την 22η έως την 40η+ με χρήση της μεθόδου LMS και δημιουργήθηκαν καμπύλες αναφοράς. Αποτελέσματα: Οι ειδικές κατά φύλο καμπύλες αναφοράς που δημιουργήθηκαν, παρέχουν σημαντικές πληροφορίες για την κατανομή του βάρους γέννησης κατά ηλικία κύησης και φύλο σε εθνικό επίπεδο και αναδεικνύουν τη σημασία της ορθής ταξινόμησης των νεογνών για την εφαρμογή πολιτικών Δημόσιας Υγείας μείωσης των νεογνικών και απώτερων επιπλοκών. Συμπέρασμα: Η παρούσα ανάλυση παρέχει σύγχρονα και ακριβή διαγράμματα εκατοστημορίων βάρους γέννησης κατά ηλικία κύησης και φύλο, βασιζόμενη σε ένα εξαιρετικά μεγάλο δείγμα περισσότερων των 600.000 νεογνών και αναδεικνύει τη σημασία του βάρους γέννησης ως παράγοντα μείζονος επιδημιολογικής σημασίας για τη Δημόσια Υγεία. Λέξεις κλειδιά: Βάρος γέννησης, ηλικία κύησης, εκατοστημόρια, επιπτώσεις, καμπύλες αναφοράς.
Physiological responses of olive cultivars to salinity stress
Creators: name: Rahemi, M.
name: Karimi, S.
name: Sedaghat, S.
name: Ali Rostami, A.
Publisher: name: Advances in Horticultural Science
Year: 2017

description: The aim of this study was to evaluate the tolerance of seven promising olive cultivars for southern parts of Iran (‘Amigdalilolia’, ‘Dakal’, ‘Zard’, ‘Dezful’, ‘Tokhm-e-Kabki’, ‘Shiraz’, and ‘Conservalia’) against salinity stress. Biochemical and physiological responses of the cultivars irrigated with saline water application (control, 4, 8, and 12 dS m-1) were evaluated and the tolerant cultivars were identified. In contrast to the tolerant cultivars, the sensitive ones continue to grow with lower rate and died under salinity stress. In general, growth indices of olive cultivars were reduced with increasing salinity stress and the lowest growth indices were obtained under 12 dS m-1 treatment. Results indicated that the accumulation of higher levels of soluble carbohydrates and proline in the leaves of the tolerant cultivars helps them to deal with salinity stress. The results showed that saline waters up to 4 dS m-1 for irrigation can be used for olive cultivars, however, based on the result of this study, it is not recommended to use water sources with higher electric conductivities to irrigate sensitive olive cultivars. We concluded that the tolerant cultivars stopped growth and used their energy to defend against the salinity stress.
description: Advances in Horticultural Science, Vol 31 No 1 (2017)
An intrinsically disordered region of methyl-CpG binding domain protein 2 (MBD2) recruits the histone deacetylase core of the NuRD complex
Creators: name: Webb, Heather D.
name: Ginder, Gordon D.
name: Scarsdale, J. Neel
name: Williams, David C.
name: Desai, Megha A.
name: Walavalkar, Ninad M.
name: Sinanan, Leander M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The MBD2-NuRD (Nucleosome Remodeling and Deacetylase) complex is an epigenetic reader of DNA methylation that regulates genes involved in normal development and neoplastic diseases. To delineate the architecture and functional interactions of the MBD2-NuRD complex, we previously solved the structures of MBD2 bound to methylated DNA and a coiled-coil interaction between MBD2 and p66α that recruits the CHD4 nucleosome remodeling protein to the complex. The work presented here identifies novel structural and functional features of a previously uncharacterized domain of MBD2 (MBD2IDR). Biophysical analyses show that the MBD2IDR is an intrinsically disordered region (IDR). However, despite this inherent disorder, MBD2IDR increases the overall binding affinity of MBD2 for methylated DNA. MBD2IDR also recruits the histone deacetylase core components (RbAp48, HDAC2 and MTA2) of NuRD through a critical contact region requiring two contiguous amino acid residues, Arg286 and Leu287. Mutating these residues abrogates interaction of MBD2 with the histone deacetylase core and impairs the ability of MBD2 to repress the methylated tumor suppressor gene PRSS8 in MDA-MB-435 breast cancer cells. These findings expand our knowledge of the multi-dimensional interactions of the MBD2-NuRD complex that govern its function.
Annotated Bibliography from A restatement of the natural science evidence base on the effects of endocrine disrupting chemicals on wildlife.
Creators: name: H. Charles J. Godfray
name: Stephens, Andrea E. A.
name: Jepson, Paul D.
name: Jobling, Susan
name: Johnson, Andrew C.
name: Matthiessen, Peter
name: Sumpter, John P.
name: Tyler, Charles R.
name: McLean, Angela R.
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Environmental Science
subject: Ecology
subject: FOS: Biological sciences
subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: Annotated Bibliography to accompany: A restatement of the natural science evidence base regarding the impacts of endocrine disrupting chemicals on wildlife.
„Das soll so richtig Bähm machen!“
Creators: name: Hempel, Christopher
Publisher: name: PraxisForschungLehrer*innenBildung. Zeitschrift für Schul- und Professionsentwicklung.
Year: 2022

description: Die gemeinsame Planung fächerübergreifenden Unterrichts erfordert allgemeindidaktische Reflexionen zur Unterrichtsgestaltung und evoziert hierauf bezogene Aushandlungen zwischen Lehrkräften. Im Kontext einer Schulbegleitforschung wurden diese Aushandlungen von drei Lehrer*innenteams unterschiedlicher Schulen, die Konzepte fächerübergreifenden Unterrichts neu entwickelten und planten, beobachtet und aufgezeichnet. Mittels Dokumentarischer Methode werden die didaktischen Prämissen sowie die kommunikativen Bezugnahmen auf die Schüler*innen analysiert, die die Unterrichtsplanung strukturieren. Dabei zeigt sich über alle drei Teams hinweg ein Anspruch an den fächerübergreifenden als außergewöhnlichen Unterricht, der unterschiedlich bestimmt wird: bezogen auf den je besonderen Unterrichtsinhalt (instruktivistisch), den Unterrichtsprozess (konstruktivistisch) oder das Unterrichtsergebnis (produktionistisch). Die mit diesen Reflexionshorizonten verbundenen Aushandlungspraxen gehen mit je spezifischen Thematisierungsweisen der Schüler*innen einher und werden begrenzt durch organisatorische Zwänge einerseits und einen kollegialen Modus der Zusammenarbeit andererseits.
description: PraxisForschungLehrer*innenBildung. Zeitschrift für Schul- und Professionsentwicklung., Bd. 4 Nr. 1 (2022): PraxisForschungLehrer*innenBildung – Ausgabe 4
Context-specific role of SOX9 in NF-Y mediated gene regulation in colorectal cancer cells
Creators: name: Mori-Akiyama, Yuko
name: Mistretta, Toni Ann
name: Zhao, Yanling
name: Yang, Jianhua
name: Maity, Sankar N.
name: Henning, Susan J.
name: Chiang, Chi I.
name: Shi, Zhongcheng
name: Labhart, Paul
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Roles for SOX9 have been extensively studied in development and particular emphasis has been placed on SOX9 roles in cell lineage determination in a number of discrete tissues. Aberrant expression of SOX9 in many cancers, including colorectal cancer, suggests roles in these diseases as well and recent studies have suggested tissue- and context-specific roles of SOX9. Our genome wide approach by chromatin immunoprecipitation sequencing (ChIP-seq) in human colorectal cancer cells identified a number of physiological targets of SOX9, including ubiquitously expressed cell cycle regulatory genes, such as CCNB1 and CCNB2, CDK1, and TOP2A. These novel high affinity-SOX9 binding peaks precisely overlapped with binding sites for histone-fold NF-Y transcription factor. Furthermore, our data showed that SOX9 is recruited by NF-Y to these promoters of cell cycle regulatory genes and that SOX9 is critical for the full function of NF-Y in activation of the cell cycle genes. Mutagenesis analysis and in vitro binding assays provided additional evidence to show that SOX9 affinity is through NF-Y and that SOX9 DNA binding domain is not necessary for SOX9 affinity to those target genes. Collectively, our results reveal possibly a context-dependent, non-classical regulatory role for SOX9.
Accuracy of home blood pressure measurement: the ACCURAPRESS study – a proposal of Young Investigator Group of the Italian Hypertension Society (Società Italiana dell’Ipertensione Arteriosa)
Creators: name: Mancusi, Costantino
name: Bisogni, Valeria
name: Maloberti, Alessandro
name: Manzi, Maria Virginia
name: Visco, Valeria
name: Biolcati, Marco
name: Giani, Valentina
name: Spannella, Francesco
name: Monticone, Silvia
name: Saladini, Francesca
name: Rivasi, Giulia
name: Turrin, Giada
name: Pucci, Giacomo
name: Pengo, Martino
name: Bertacchini, Fabio
name: Ferri, Claudio
name: Grassi, Guido
name: Muiesan, Maria Lorenza
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Home blood pressure monitoring (HBPM) might be considered a valid alternative to ambulatory blood pressure monitoring (ABPM) for both the diagnosis and management of hypertension. Correct information on how to perform HBPM are crucial for its reliability. The aim of the present survey was to assess if hypertensive patients followed current recommendation on how to correctly perform HBPM measurements. The survey included 30 different items on how to perform the HBPM. It was developed by the ‘Young Investigators’ group of the Italian Society of Arterial Hypertension (SIIA) and it was administered during the office visit between May 2019 and December 2021. A total of 643 hypertensive patients participated in the study. Main results show that, despite the rate of informed patients was relatively high (71% of the whole population), unacceptable number of patients did not follow indications on how to perform a correct HBPM. Patients who were informed on how to measure home BP had a significantly higher rate of correct position during measurement (78 vs. 22%, p < 0.01), avoidance of talking and moving during measurement (68 vs. 32%, p < 0.0001), and correct number and time interval between two measurements (85 vs. 15%, p < 0.001). More accurate measurements of home BP were associated with less prevalence of carotid plaque. Correct performance for HBPM is low among patients treated in Italian hypertension centers. These findings shed light on the importance of correct HBPM measurements for the detection of accurate BP values for the proper management of hypertensive patients.
The impact of fruit temperature dynamics on heat stress tolerance of selected oil pumpkin genotypes
Creators: name: Urban Krajnc, A.
name: Rakun, J.
name: Berk, P.
name: Ivancic, A.
Publisher: name: Advances in Horticultural Science
Year: 2017

description: Fruit temperature is a key parameter for fruit growth and quality which is affected by climate, plant vigorousity, solar exposure and fruit thermal properties. In the present study, the variability in temperature dynamics of Styrian oil pumpkin fruits and selected interspecific hybrids involving Cucurbita argyrosperma, C. moschata, C. pepo was analysed in two different periods of hot weather. The temperatures were measured with thermistors on (a) attached fruits, (b) detached fruits exposed to the sun and (c) artificially black coloured fruits. The highest average temperatures were determined in the Styrian oil pumpkin, whereas the lowest temperatures were determined in genotypes with lighter fruit exteriors suggesting that those are less sensitive to heat stress conditions and may represent a good option for the improvements of adaptability to climatic changes. In order to combine lighter and harder pericarp, the most promising genotypes were crossed with wild Cucurbita okeechobeensis. The histological analysis showed that C. okeechobeensis was a good source of genes for obtaining a thicker sclerenchymatic layer within pericarp
description: Advances in Horticultural Science, Vol 31 No 1 (2017)
title: Πρότυπα ηλεκτρολογικών εγκαταστάσεων και σύγχρονα λογισμικά σχεδίασης ηλεκτρολογικών σχεδίων αυτοματισμού και ισχύος
title: Electrical installation standards and modern automation and power electrical schematic design software
titleType: AlternativeTitle
Creators: name: Τσάνας, Βασίλειος
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2022
Subjects: Πρότυπα ηλεκτρολογικών εγκαταστάσεων
Ηλεκτρολογικές εγκαταστάσεις
Σύγχρονα λογισμικά σχεδίασης
Εγκαταστάσεις
Πρότυπο IEC
Πρότυπο HD 384
AutoCAD
EPLAN Electric P8
Ηλεκτρολογικοί πίνακες
Καλωδίωση
Πίνακας αυτοματισμού
Ηλεκτρικά σύμβολα
Ballast water treatment system
Διακόπτες ισχύος
Προστασία
Πίνακες διανομής
Ηλεκτρολογικό σχέδιο

description: Έρευνα πάνω στις παραμέτρους των καλωδιώσεων, ηλεκτρολογικών πινάκων στις εγκαταστάσεις κτιρίων/ πλοίων, αναφοράα στα σύγχρονα λογισμικά σχεδίασης ηλεκτρολογικών σχεδίων και εφαρμογή όλων των παραπάνω σε μηχάνημα επιλογής.
Bosonic hard spheres in quasi-one dimensional bichromatic optical lattices
Creators: name: Gordillo, M. C.
name: Carbonell-Coronado, C.
name: De Soto, F.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We calculated the phase diagram of a continuous system of hard spheres loaded in a quasi-one dimensional bichromatic optical lattice. The wavelengths of both lattice-defining lasers were chosen to model an incommensurate arrangement. Densities of one particle and half a particle per potential well were considered. Our results can be compared directly to those of the experimental system [Fallani et al. PRL, {\bf 98} 130404 (2007)] from which our initial parameters were taken. The phase diagrams for both densities are significatively different to those obtained by describing the same experimental setup with a Bose-Hubbard model.
description: 6 figures
Additional file 1 of Antiosteoporosis effect and possible mechanisms of the ingredients of Radix Achyranthis Bidentatae in animal models of osteoporosis: systematic review and meta-analysis of in vivo studies
Creators: name: Lian, Yong
name: Zhu, Haoran
name: Guo, Xiaxia
name: Fan, Yinuo
name: Xie, Zhixing
name: Xu, Jinfan
name: Shao, Min
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1. Supplementary Table. A detailed list of excluded studies with reasons, references and number.
Resonant-bar detectors of gravitational wave as possible probe of the noncommutative structure of space
Creators: name: Saha, Anirban
name: Gangopadhyay, Sunandan
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We report the plausibility of using quantum mechanical transitions, induced by the combined effect of Gravitational wave (GW) and noncommutative (NC) structure of space, among the states of a 2-dimensional harmonic oscillator, to probe the spatial NC geometry. The phonon modes excited by the passing GW within the resonant bar-detector are formally identical to forced harmonic oscillator and they represent a length variation of roughly the same order of magnitude as the characteristic length-scale of spatial noncommutativity estimated from the phenomenological upper bound of the NC parameter. This motivates our present work. We employ various GW wave-forms that are typically expected from possible astronomical sources. We find that the transition probablities are quite sensitive to the nature of polarization of the GW. We also elaborate on the particular type of sources of GW, radiation from which can induce transitions that can be used as effective probe of the spatial noncommutative structure.
description: Title changed, Abstract rewriten, paper revised, 6 pages, RevTex, No figures
Detecting riboSNitches with RNA folding algorithms: a genome-wide benchmark
Creators: name: Qu, Kun
name: Corley, Meredith
name: Chang, Howard Y.
name: Laederach, Alain
name: Solem, Amanda
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Ribonucleic acid (RNA) secondary structure prediction continues to be a significant challenge, in particular when attempting to model sequences with less rigidly defined structures, such as messenger and non-coding RNAs. Crucial to interpreting RNA structures as they pertain to individual phenotypes is the ability to detect RNAs with large structural disparities caused by a single nucleotide variant (SNV) or riboSNitches. A recently published human genome-wide parallel analysis of RNA structure (PARS) study identified a large number of riboSNitches as well as non-riboSNitches, providing an unprecedented set of RNA sequences against which to benchmark structure prediction algorithms. Here we evaluate 11 different RNA folding algorithms’ riboSNitch prediction performance on these data. We find that recent algorithms designed specifically to predict the effects of SNVs on RNA structure, in particular remuRNA, RNAsnp and SNPfold, perform best on the most rigorously validated subsets of the benchmark data. In addition, our benchmark indicates that general structure prediction algorithms (e.g. RNAfold and RNAstructure) have overall better performance if base pairing probabilities are considered rather than minimum free energy calculations. Although overall aggregate algorithmic performance on the full set of riboSNitches is relatively low, significant improvement is possible if the highest confidence predictions are evaluated independently.
High-throughput screening identifies small molecules that enhance the pharmacological effects of oligonucleotides
Creators: name: Porter, M. A.
name: Suto, M.
name: Ming, X.
name: Yuan, A.
name: Maddry, J.
name: Janzen, W. P.
name: Laing, B.
name: Juliano, R. L.
name: Hull-Ryde, E. A.
name: Yang, B.
name: Cao, C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The therapeutic use of antisense and siRNA oligonucleotides has been constrained by the limited ability of these membrane-impermeable molecules to reach their intracellular sites of action. We sought to address this problem using small organic molecules to enhance the effects of oligonucleotides by modulating their intracellular trafficking and release from endosomes. A high-throughput screen of multiple small molecule libraries yielded several hits that markedly potentiated the actions of splice switching oligonucleotides in cell culture. These compounds also enhanced the effects of antisense and siRNA oligonucleotides. The hit compounds preferentially caused release of fluorescent oligonucleotides from late endosomes rather than other intracellular compartments. Studies in a transgenic mouse model indicated that these compounds could enhance the in vivo effects of a splice-switching oligonucleotide without causing significant toxicity. These observations suggest that selected small molecule enhancers may eventually be of value in oligonucleotide-based therapeutics.
A capstone project report submitted to the school of graduate studies of Addis Ababa University, college of Health Science, Department of Health Service Management and Policy in partial fulfillment of the requirements for the degree of Masters of science in Hospital and Health Care Administration
Creators: name: Dereje Bokan
Publisher: name: Zenodo
Year: 2019

description: Background: Medical records management is one of the components of health information

system that documents information related to a patient generated during patient-to-health care

provider encounters at a health care facility. A well-managed medical records system is critical

to improve the provision of quality health care services to ensure safe medical practice, efficient

and effective services and improve the patient’s experience and satisfaction with their medical

encounter.

Objective:-To improve outpatient medical record completion from 37% to 90% in

Enchini Hospital at the end of June 2019GC
(401236) Stanley Arthur Neve
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Improving gravity inversion by geostatistical simulation of constraining data - case study: southern Africa crustal thickness model
Creators: name:  Menzel , Peter
name:  Sobh , Mohamed
name:  Fadel , Islam
name:  Gerhards , Christian
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: The inversion of gravity data for crustal thicknesses is a nonunique problem. Therefore, additional independent information (e.g., seismic data) is needed to constrain the inversion process. Despite decades of exploration efforts related to mining and the installation of more seismic stations, knowledge on the deep crustal structure of southern Africa remains limited. In this contribution we present a crustal thickness model for southern Africa: The initial model is determined by inversion of satellite gravity data. Here, we apply seismically constrained non-linear inversion, based on the modified Bott's method and Tikhonov regularization assuming spherical Earth approximation. The inversion hyper-parameters are determined by Monte-Carlo-Marcov-Chain (MCMC) simulation. The data quality of the (active and passive) seismic constraints is high in general, showing e.g. individual uncertainties per point. The problem is that the constraining data points are irregularly distributed, resulting in large areas without constraints. Therefore, in a next step, we want to validate and improve the modelling result for these unconstrained regions. We use the initial constraining data set to geostatistically simulate a homogeneous crustal thickness model for the investigation region. For this, we apply a Sequential Gaussian Simulation (SGS) based on Ordinary Kriging that includes the uncertainties of the seismic data and allows to characterize uncertainties of the simulated points. The simulated crustal thickness model is then used to qualitatively validate the inversion result. Additionally, we redo the inversion process with a new constraining data set that combines the preexisting constraining points and the simulated model.
SwiftLib: rapid degenerate-codon-library optimization through dynamic programming
Creators: name: Yumerefendi, Hayretin
name: Leaver-Fay, Andrew
name: Jacobs, Timothy M.
name: Kuhlman, Brian
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Degenerate codon (DC) libraries efficiently address the experimental library-size limitations of directed evolution by focusing diversity toward the positions and toward the amino acids (AAs) that are most likely to generate hits; however, manually constructing DC libraries is challenging, error prone and time consuming. This paper provides a dynamic programming solution to the task of finding the best DCs while keeping the size of the library beneath some given limit, improving on the existing integer-linear programming formulation. It then extends the algorithm to consider multiple DCs at each position, a heretofore unsolved problem, while adhering to a constraint on the number of primers needed to synthesize the library. In the two library-design problems examined here, the use of multiple DCs produces libraries that very nearly cover the set of desired AAs while still staying within the experimental size limits. Surprisingly, the algorithm is able to find near-perfect libraries where the ratio of amino-acid sequences to nucleic-acid sequences approaches 1; it effectively side-steps the degeneracy of the genetic code. Our algorithm is freely available through our web server and solves most design problems in about a second.
New method for evaluating artificial neural network algorithm with signal detection theory and full factorial design for detecting falls
Creators: name: Uttapon Khawnuan
name: Teppakorn Sittiwanchai
name: Nantakrit Yodpijit
Publisher: name: Faculty of Engineering, Khon Kaen University
Year: 2023
Subjects: Falls detection
Wearable sensor
Artifact Neural Network (ANN)
Signal Detection Theory (SDT)
Full factorial design (FFD)

description: Engineering and Applied Science Research, 50, 1, 33-46
Annotated Bibliography from A restatement of the natural science evidence base on the effects of endocrine disrupting chemicals on wildlife
Creators: name: H. Charles J. Godfray
name: Stephens, Andrea E. A.
name: Jepson, Paul D.
name: Jobling, Susan
name: Johnson, Andrew C.
name: Matthiessen, Peter
name: Sumpter, John P.
name: Tyler, Charles R.
name: McLean, Angela R.
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Environmental Science
subject: Ecology
subject: FOS: Biological sciences
subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: Annotated Bibliography to accompany: A restatement of the natural science evidence base regarding the impacts of endocrine disrupting chemicals on wildlife.
(401234) Albert March
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.