cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
'The Barghest o' Whitby' : (a genealogical study of) death/doom metal music(al) network in Northern England
Creators: name: Yavuz, Mehmet
Publisher: name: Leeds Beckett University
Year: 2022
Subjects: Uncategorized

description: Metal music has existed in one form or another for about half a century. While the musical style and the culture started out in a relatively unified way, with the ‘extreme turn’ of late 80s and 90s, metal culture stratified. Doom metal, being one of the oldest styles in this newly formed structure, became even more fragmented. Through amalgamations with other music styles or as further alterations on these amalgamations. I call these styles extreme doom. Death/doom is such a style. These smaller styles in metal culture have so far been investigated hierarchically. However, the implication that a hierarchy has is problematic in this context. Metal music studies is a budding field, so, we need to think more critically about the way we conceptualise the history of metal academically in these early years. Yet, so far, this stratification, with its hierarchy, has not been challenged or even discussed in detail. Scholarship often mentions these so-called ‘sub-genres’ uncritically. In order to challenge this idea, there needs to be a new model. However, because of the size and breadth of metal culture, one single work cannot come even close to covering the styles existing today. In this thesis, I attempt to draw boundaries around only death/doom to propose a way of modelling a new metal history. To achieve this, I define these newer and smaller styles as marginal styles using marginality idea of Park. Following this idea, sociology of music comes to rescue with Crossley’s music worlds. Music worlds, because of its emphasis put on the musical style -it is central-, is an intriguing perspective to look at the fragmented nature of metal music. A metal music world is a social construction performed by the participants, including musicians, fans, engineers, managers, label executives, and the press, around a metal musical style. These smaller styles, then, become ideal candidates for the application of this theory. This thesis treats death/doom in such a way using ethnographic, historical, and musicological methods.
Mass media and heterogeneous bounds of confidence in continuous opinion dynamics
Creators: name: Pineda, M.
name: Buendia, G. M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Physics and Society (physics.soc-ph)
subject: FOS: Physical sciences

description: This work focus on the effects of an external mass media on continuous opinion dynamics with heterogeneous bounds of confidence. We modified the original Deffuant et al. and Hegselmann and Krause models to incorporate both, an external mass media and a heterogeneous distribution of confidence levels. We analysed two cases, one where only two bounds of confidence are taken into account, and other were each individual of the system has her/his own characteristic level of confidence. We found that, in the absence of mass media, diversity of bounds of confidence can improve the capacity of the systems to reach consensus. We show that the persuasion capacity of the external message is optimal for intermediate levels of heterogeneity. Our simulations also show the existence, for certain parameter values, of a counter-intuitive effect in which the persuasion capacity of the mass media decreases if the mass media intensity is too large. We discuss similarities and differences between the two heterogeneous versions of these continuous opinion dynamic models under the influence of mass media.
Disrupted-in-Schizophrenia-1 expression is regulated by  -site amyloid precursor protein cleaving enzyme-1-neuregulin cascade
Creators: name: Kano, S.-i.
name: Prikulis, I.
name: Seshadri, S.
name: Wong, P.
name: Eom, T.-Y.
name: Korth, C.
name: Hayashi-Takagi, A.
name: Yokota, Y.
name: Kamiya, A.
name: Sawa, A.
name: Ishizuka, K.
name: Anton, E. S.
name: Stanco, A.
name: Rao, S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Neuregulin-1 (NRG1) and Disrupted-in-Schizophrenia-1 (DISC1) are promising susceptibility factors for schizophrenia. Both are multifunctional proteins with roles in a variety of neurodevelopmental processes, including progenitor cell proliferation, migration, and differentiation. Here, we provide evidence linking these factors together in a single pathway, which is mediated by ErbB receptors and PI3K/Akt. We show that signaling by NRG1 and NRG2, but not NRG3, increase expression of an isoform of DISC1 in vitro. Receptors ErbB2 and ErbB3, but not ErbB4, are responsible for transducing this effect, and PI3K/Akt signaling is also required. In NRG1 knockout mice, this DISC1 isoform is selectively reduced during neurodevelopment. Furthermore, a similar decrease in DISC1 expression is seen in β-site amyloid precursor protein cleaving enzyme–1 (BACE1) knockout mice, in which NRG1/Akt signaling is reportedly impaired. In contrast to neuronal DISC1 that was reported and characterized, expression of DISC1 in other types of cells in the brain has not been addressed. Here we demonstrate that DISC1, like NRG and ErbB proteins, is expressed in neurons, astrocytes, oligodendrocytes, microglia, and radial progenitors. These findings may connect NRG1, ErbBs, Akt, and DISC1 in a common pathway, which may regulate neurodevelopment and contribute to susceptibility to schizophrenia.
Modeling Polyp Activity of Paragorgia arborea Using Supervised Learning
Creators: name: Johanson, Arne
name: Flögel, Sascha
name: Dullo, Wolf-Christian
name: Linke, Peter
name: Hasselbring, Wilhelm
Publisher: name: arXiv
Year: 2022
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: Machine Learning (cs.LG)
subject: FOS: Biological sciences
subject: FOS: Computer and information sciences
subject: I.2.6

description: While the distribution patterns of cold-water corals, such as Paragorgia arborea, have received increasing attention in recent studies, little is known about their in situ activity patterns. In this paper, we examine polyp activity in P. arborea using machine learning techniques to analyze high-resolution time series data and photographs obtained from an autonomous lander cluster deployed in the Stjernsund, Norway. An interactive illustration of the models derived in this paper is provided online as supplementary material. We find that the best predictor of the degree of extension of the coral polyps is current direction with a lag of three hours. Other variables that are not directly associated with water currents, such as temperature and salinity, offer much less information concerning polyp activity. Interestingly, the degree of polyp extension can be predicted more reliably by sampling the laminar flows in the water column above the measurement site than by sampling the more turbulent flows in the direct vicinity of the corals. Our results show that the activity patterns of the P. arborea polyps are governed by the strong tidal current regime of the Stjernsund. It appears that P. arborea does not react to shorter changes in the ambient current regime but instead adjusts its behavior in accordance with the large-scale pattern of the tidal cycle itself in order to optimize nutrient uptake.
description: 25 pages
The Pulsating Arc Discharge As A Sound Source For Use In The Measurement Of Acoustic Stability Parameters In Operational Combustion Systems
Creators: name: Vuillermoz, Maxime
Publisher: name: London South Bank University
Year: 1984

description: A brief review of previous work on acoustic instabilities in combustion is presented, drawing the conclusion that a sound source of known strength located at the flame could provide an improved technique for determining the important acoustic stability parameters of working combustion systems. A theoretical and experimental investigation of the properties of a pulsating are discharge as a sound source is described, which indicates that such a source would be particularly suitable for that purpose. The investigation adds to and modifies the results of other workers on sound emission from gaseous discharge, specifically in interpreting the influence on sound output of the temperature of the discharge and the acoustic coupling between the source and the radiation field. A formula is derived giving the equivalent free-field acoustic strength of the are for use at low frequencies which is shown to accord with the experimental findings. The pulsating are source, used in a laboratory model combustion system, is capable of providing the acoustic impedance relevant to sound power emission and those transfer terms which describe any acoustic amplification brought about by the combustion process. The impedance measurements are shown to be in general agreement with theoretical prediction and an analysis of the system, based on a simple electrical analogue and using the measured transfer terms, is shown to give the correct stability boundaries for the system examined. The analysis, which differs from that of previous workers, treats the flame and the system as a single component in a feed-back loop; but distinguishes the specific contribution to stability conditions of local acoustic pressure and the volume velocity generated by the source process. Limitations of the technique are discussed and other uses for the are considered, including its operation as a suitable source for anti-sound.
title: ГЕМАНГИОМА ЛЕВОЙ ДОЛИ ПЕЧЕНИ:КЛИНИЧЕСКОЕ НАБЛЮДЕНИЕ
Creators: name: Одишелашвили, Гиви Доментиевич
name: Пахнов, Дмитрий Владимирович
name: Одишелашвили, Ната Гивиевна
Publisher: name: Астраханский государственный медицинский университет
Year: 2022
Subjects: subject: Clinical medicine
subject: FOS: Clinical medicine

description: Рассмотрен результат успешного лечения пациентки с гемангиомой печени. Детально описана лечебно-диагностическая тактика при указанной патологии. Клинический материал представлен случаем из практики лечения. Из анамнестических данных установлено, что в марте 2017 г. во время очередного обследования, проводимого в рамках диспансерного наблюдения, при ультразвуковом исследовании у пациентки было обнаружено образование в левой доле печени. При постановке диагноза руководствовались выполнением необходимых лабораторных и инструментальных исследований. Лечебная тактика имела этапный подход: на первом этапе выполнено эндоваскулярное вмешательство, на втором  – гемигепатэктомия слева. После проведенного лечения состояние больной улучшилось, в удовлетворительном состоянии она была выписана.
Quality Assurance of Weld Seams Using Laser Triangulation Imaging and Deep Neural Networks
Creators: name: Spruck, Andreas
name: Seiler, Jürgen
name: Roll, Michael
name: Dudziak, Thomas
name: Eckstein, Jürgen
name: Kaup, André
Publisher: name: arXiv
Year: 2022
Subjects: subject: Image and Video Processing (eess.IV)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In this paper, a novel optical inspection system is presented that is directly suitable for Industry 4.0 and the implementation on IoT-devices controlling the manufacturing process. The proposed system is capable of distinguishing between erroneous and faultless weld seams, without explicitly defining measurement criteria . The developed system uses a deep neural network based classifier for the class prediction. A weld seam dataset was acquired and labelled by an expert committee. Thereby, the visual impression and assessment of the experts is learnt accurately. In the scope of this paper laser triangulation images are used. Due to their special characteristics, the images must be pre-processed to enable the use of a deep neural network. Furthermore, two different approaches are investigated to enable an inspection of differently sized weld seams. Both approaches yield very high classification accuracies of up to 96.88\%, which is competitive to current state of the art optical inspection systems. Moreover, the proposed system enables a higher flexibility and an increased robustness towards systematic errors and environmental conditions due to its ability to generalize. A further benefit of the proposed system is the fast decision process enabling the usage directly within the manufacturing line. Furthermore, standard hardware is used throughout the whole presented work, keeping the roll-out costs for the proposed system as low as possible.
title: Combining sandwich care with work: Interviews with Chinese young working sandwich caregivers
Creators: name: He, Ling
Publisher: name: University of Glasgow
Year: 2023

description: This thesis explores the caregiving experience of young sandwich caregivers in work. Mainstream sandwich care literature, due to its simplistic view on care as mainly involves instrumental and tangible forms, largely neglects the scope and complexity of sandwich care. The key aim of this thesis is therefore to make further theoretical and empirical developments to the conceptualisation of care. Theoretically, this research contributes to extending the theorisation of care in sandwich care literature by exploring the aspects of care that remain hidden and under-researched. Concerning complexity of caregiving, the gendered power dynamics inherent in a variety of caring relations and caregivers’ context-bounded agency are investigated. From an empirical perspective, the contributions are twofold as the results not only highlight the struggle experienced by young workers, but also offer insights about caregiving and dynamic relations in Chinese Confucian context, which has not been developed adequately in the field of sandwich care. This thesis adopts a qualitative approach following symbolic interactionism. Using data collected from 40 sandwich caregivers in work, the thesis makes theoretical contributions to the conceptualisation of care and sandwich caregivers through perspectives of hidden elements and power-laden nature of care. The findings demonstrate that care involves a variety of forms, and the hidden forms (i.e., technological and lingual care) play significant roles in shaping young workers’ experience of care. Combining sandwich care with work is challenging at the stage when parents/parents-in-law are relatively young and when children are dependent, as young workers are facing the unique sandwichness caused by both present and future worries. Yet, young workers do not always unthinkingly perform care and work. Importantly, they have certain level of agency in navigating the complexity of care through reciprocal relationships in the workplace and family realms, and by crafting certain impressions on audiences. This agency, however, has largely been constrained by structural and cultural factors and with gendered implications, reflecting Confucian values surrounding respect to hierarchy, and usually the gendered hierarchy characterising women’ subordination and men’s privilege.
The EU Web Accessibility Directive – and what it means for school websites
Creators: name: Marcus Quinn, Ann
name: Hourigan, Tríona
Publisher: name: University of Limerick
Year: 2022
Subjects: Language, communication and culture

description: Since the 1990s, the majority of post-primary schools in Ireland have had an online presence. For many schools this is now a school website. Everyone involved in the school community will have some interaction with the school website, whether it is to check the school calendar or to read a school policy (Gilleece & Eivers, 2018; Lalchandani et al, 2022). However, for some, this task is much more difficult than for others (Orero & Quested, 2022).
Distinct forms of Gq-receptor-dependent plasticity of excitatory transmission in the BNST are differentially affected by stress
Creators: name: Nobis, W. P.
name: Winder, D. G.
name: Klug, J. R.
name: Grueter, B. A.
name: McElligott, Z. A.
name: Patel, S.
name: Kash, T. L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Long-term depression (LTD) is an important synaptic mechanism for limiting excitatory influence over circuits subserving cognitive and emotional behavior. A major means of LTD induction is through the recruitment of signaling via Gq-linked receptors activated by norepinephrine (NE), acetylcholine, and glutamate. Receptors from these transmitter families have been proposed to converge on a common postsynaptic LTD maintenance mechanism, such that hetero- and homosynaptic induction produce similar alterations in glutamate synapse efficacy. We report that in the dorsolateral and ventrolateral bed nucleus of the stria terminalis (BNST), recruitment of Gq-linked receptors by glutamate or NE initiates mechanistically distinct forms of postsynaptically maintained LTD and these LTDs are differentially regulated by stress exposure. In particular, we show that although both mGluR5- and α1-adrenergic receptor (AR)-dependent LTDs involve postsynaptic endocytosis, the α1-AR-initiated LTD exclusively involves modulation of signaling through calcium-permeable AMPA receptors. Further, α1-AR- but not mGluR5- dependent LTD is disrupted by restraint stress. α1-AR LTD is also impaired in mice chronically exposed to ethanol. These data thus suggest that in the BNST, NE- and glutamate-activated Gq-linked signaling pathways differentially tune glutamate synapse efficacy in response to stress.
Engineering a protein-protein interface using a computationally designed library
Creators: name: Kuhlman, B.
name: Guntas, G.
name: Purbeck, C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Computational algorithms for protein design can sample large regions of sequence space, but suffer from undersampling of conformational space and energy function inaccuracies. Experimental screening of combinatorial protein libraries avoids the need for accurate energy functions, but has limited access to vast amounts of sequence space. Here, we test if these two traditionally alternative, but potentially complementary approaches can be combined to design a variant of the ubiquitin-ligase E6AP that will bind to a nonnatural partner, the NEDD8-conjugating enzyme Ubc12. Three E6AP libraries were constructed: (i) a naive library in which all 20 amino acids were allowed at every position on the target-binding surface of E6AP (13 positions), (ii) a semidirected library that varied the same residue positions as in the naive library but disallowed mutations computationally predicted to destabilize E6AP, and (iii) a directed library that used docking and sequence optimization simulations to identify mutations predicted to be favorable for binding Ubc12. Both of the directed libraries showed > 30-fold enrichment over the naive library after the first round of screening with a split-dihydrofolate reductase complementation assay and produced multiple tight binders (Kd < 100 nM) after four rounds of selection. Four rounds of selection with the naive library failed to produce any binders with Kd’s lower than 50 μM. These results indicate that protein design simulations can be used to create directed libraries that are enriched in tight binders and that in some cases it is sufficient to computationally screen for well-folded sequences without explicit binding calculations.
Total-variation-based methods for gravitational wave denoising
Creators: name: Torres, Alejandro
name: Marquina, Antonio
name: Font, José A.
name: Ibáñez, José M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: We describe new methods for denoising and detection of gravitational waves embedded in additive Gaussian noise. The methods are based on Total Variation denoising algorithms. These algorithms, which do not need any a priori information about the signals, have been originally developed and fully tested in the context of image processing. To illustrate the capabilities of our methods we apply them to two different types of numerically-simulated gravitational wave signals, namely bursts produced from the core collapse of rotating stars and waveforms from binary black hole mergers. We explore the parameter space of the methods to find the set of values best suited for denoising gravitational wave signals under different conditions such as waveform type and signal-to-noise ratio. Our results show that noise from gravitational wave signals can be successfully removed with our techniques, irrespective of the signal morphology or astrophysical origin. We also combine our methods with spectrograms and show how those can be used simultaneously with other common techniques in gravitational wave data analysis to improve the chances of detection.
description: 14 pages, 12 figures, to appear on Physical Review D
The Tort of Misuse of Public Office: Suggested Clarifications and Reforms
Creators: name: Gray, Anthony
Publisher: name: Monash University
Year: 2023
Subjects: Administrative law
Public law not elsewhere classified
Tort law

description: Recently the Federal Court of Australia found that a Commonwealth Minister had committed the tort of misuse of public office. While this claim is often brought, it is usually unsuccessful, making this case noteworthy. The case shines a spotlight on this unusual tort. While it has a lengthy history in the common law, many of its contours remain unresolved. This article will explain the basis of the tort, before considering how it has developed in the United Kingdom and Australia. It will consider differences, or possible differences, between the tort in the two jurisdictions. It then critically considers some important aspects of the tort about which there continues to be controversy, including the notion of a public office, the question of vicarious liability, the question whether a duty of care is necessary, and the mental element required. It suggests some important changes in how courts should apply these principles in future cases, to better reflect the realities of government today, the rationale of the tort, and to make it consistent with the courts’ approach to other intent-based torts with which the High Court has specifically related to this novel tort.
On the Class II Methanol Maser Periodic Variability due to the Rotating Spiral Shocks in the Gaps of Disks Around Young Binary Stars
Creators: name: Parfenov, S. Yu.
name: Sobolev, A. M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We argue that the periodic variability of Class II methanol masers can be explained by variations of the dust temperature in the accretion disk around proto-binary star with at least one massive component. The dust temperature variations are caused by rotation of hot and dense material of the spiral shock wave in the disk central gap. The aim of this work is to show how different can be the Class II methanol maser brightness in the disk during the Moment of Maximum Illumination by the Spiral Shock material (hereafter MMISS) and the Moment when the disk is Illuminated by the Stars Only (MISO). We used the code CLOUDY (v13.02) to estimate physical conditions in the flat disk in the MISO and the MMISS. Model physical parameters of the disk were then used to estimate the brightness of 6.7, 9.9, 12.1 and 107 GHz masers at different impact parameters $p$ using LVG approximation. It was shown that the strong masers experience considerable brightness increase during the MMISS with respect to MISO. There can happen both flares and dips of the 107 GHz maser brightness under the MMISS conditions, depending on the properties of the system. The brightest 9.9 GHz masers in the MMISS are situated at the greater $p$ than the strong 6.7, 12.1 and 107 GHz masers that are situated at $p<200$ AU. The brightness of 9.9 GHz maser in the MMISS suppressed at $p<200$ AU and increase at $p>200$ AU.
description: Accepted for publication in MNRAS, 9 figures
CoreTrustSeal Trustworthy Data Repositories Requirements: Extended Guidance 2023-2025. Nederlandse vertaling
Creators: name: Data Archiving And Networked Services (DANS-KNAW)
Publisher: name: Zenodo
Year: 2022
Subjects: CoreTrustSeal
Certification
Requirements
Trustworthy Digital Repository
Translation
Certificering
Toelichting

description: Dit document is een Nederlandse vertaling van 'CoreTrustSeal Trustworthy Digital Repositories Requirements 2023-2025 Extended Guidance' (https://doi.org/10.5281/zenodo.7051096), gecreëerd door DANS ten behoeve van de Wegwijzer Certificering (https://wegwijzercertificering.nl/nl). De Wegwijzer Certificering is een voorziening van het Netwerk Digitaal Erfgoed, geborgd door DANS, die ondersteuning biedt aan erfgoedinstellingen om aan de slag te gaan met de certificering van hun archief. De Nederlandse vertaling van de CoreTrustSeal documenten kan worden gebruikt in het aanmeldingsproces om de Requirements beter te begrijpen in de eigen context.
description: NB: Dit document is niet door CoreTrustSeal gecreëerd en is daarom niet leidend. De originele CoreTrustSeal documentatie is de enige gezaghebbende (https://doi.org/10.5281/zenodo.7051096). Aanmeldingen voor CoreTrustSeal certificering dienen in het Engels ingediend te worden.
Exposing malaria in-host diversity and estimating population diversity by capture-recapture using massively parallel pyrosequencing
Creators: name: Wongsrichanalai, C.
name: Mwapasa, V.
name: Juliano, J. J.
name: Sem, R.
name: Rogers, W. O.
name: Porter, K.
name: Read, A.
name: Ariey, F.
name: Meshnick, S. R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Malaria infections commonly contain multiple genetically distinct variants. Mathematical and animal models suggest that interactions among these variants have a profound impact on the emergence of drug resistance. However, methods currently used for quantifying parasite diversity in individual infections are insensitive to low-abundance variants and are not quantitative for variant population sizes. To more completely describe the in-host complexity and ecology of malaria infections, we used massively parallel pyrosequencing to characterize malaria parasite diversity in the infections of a group of patients. By individually sequencing single strands of DNA in a complex mixture, this technique can quantify uncommon variants in mixed infections. The in-host diversity revealed by this method far exceeded that described by currently recommended genotyping methods, with as many as sixfold more variants per infection. In addition, in paired pre- and posttreatment samples, we show a complex milieu of parasites, including variants likely up-selected and down-selected by drug therapy. As with all surveys of diversity, sampling limitations prevent full discovery and differences in sampling effort can confound comparisons among samples, hosts, and populations. Here, we used ecological approaches of species accumulation curves and capture-recapture to estimate the number of variants we failed to detect in the population, and show that these methods enable comparisons of diversity before and after treatment, as well as between malaria populations. The combination of ecological statistics and massively parallel pyrosequencing provides a powerful tool for studying the evolution of drug resistance and the in-host ecology of malaria infections.
Genome-wide model for the normal eukaryotic DNA replication fork
Creators: name: Mieczkowski, Piotr A.
name: McElhinny, Stephanie A. Nick
name: Lujan, Scott A.
name: Resnick, Michael A.
name: Gordenin, Dmitry A.
name: Kunkel, Thomas A.
name: Larrea, Andres A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: To investigate DNA replication enzymology across the nuclear genome of budding yeast, deep sequencing was used to establish the pattern of uncorrected replication errors generated by an asymmetric mutator variant of DNA polymerase δ (Pol δ). Sequencing of 16 genomes identified 1,206-bp substitutions generated over 33 generations by L612M Pol δ in a mismatch repair defective strain. Alignment of sequences flanking these substitutions identified “hotspot” motifs for Pol δ replication errors. The substitutions were distributed evenly across all 16 chromosomes. The vast majority were transitions that occurred with a strand bias that varied in a predictable manner relative to known functional origins of replication. This strand bias strongly supports the idea that Pol δ is primarily a lagging strand polymerase during replication across the entire nuclear genome.
Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy
Creators: name: Wang, L.
name: Olson, E. N.
name: Konno, T.
name: Kawana, M.
name: Gorham, J. M.
name: Seidman, J. G.
name: Wakimoto, H.
name: Pandya, K.
name: Chen, D.
name: Smithies, O.
name: Seidman, C. E.
name: Naya, F. J.
name: Teekakirikul, P.
name: Eminaga, S.
name: Nayor, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Unknown molecular responses to sarcomere protein gene mutations account for pathologic remodeling in hypertrophic cardiomyopathy (HCM), producing myocyte growth and increased cardiac fibrosis. To determine if hypertrophic signals activated myocyte enhancer factor-2 (Mef2), we studied mice carrying the HCM mutation, myosin heavy-chain Arg403Gln, (MHC403/+) and an Mef2-dependent β-galactosidase reporter transgene. In young, prehypertrophic MHC403/+ mice the reporter was not activated. In hypertrophic hearts, activation of the Mef2-dependent reporter was remarkably heterogeneous and was observed consistently in myocytes that bordered fibrotic foci with necrotic cells, MHC403/+ myocytes with Mef2-dependent reporter activation reexpressed the fetal myosin isoform (βMHC), a molecular marker of hypertrophy, although MHC403/+ myocytes with or without βMHC expression were comparably enlarged over WT myocytes. To consider Mef2 roles in severe HCM, we studied homozygous MHC403/403 mice, which have accelerated remodeling, widespread myocyte necrosis, and neonatal lethality. Levels of phosphorylated class II histone deacetylases that activate Mef2 were substantially increased in MHC403/403 hearts, but Mef2-dependent reporter activation was patchy. Sequential analyses showed myocytes increased Mef2-dependent reporter activity before death. Our data dissociate myocyte hypertrophy, a consistent response in HCM, from heterogeneous Mef2 activation and reexpression of a fetal gene program. The temporal and spatial relationship of Mef2-dependent gene activation with myocyte necrosis and fibrosis in MHC403/+ and MHC403/403 hearts defines Mef2 activation as a molecular signature of stressed HCM myocytes that are poised to die.
Semiparametric estimation of duration models when the parameters are subject to inequality constraints and the error distribution is unknown
Creators: name: Ranasinghe, Kulan
name: Silvapulle, Mervyn J.
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: The parameters in duration models are usually estimated by a Quasi Maximum Likelihood Estimator [QMLE]. This estimator is efficient if the errors are iid and exponentially distributed. Otherwise, it may not be the most efficient. Motivated by this, a class of estimators has been introduced by Drost and Werker (2004). Their estimator is asymptotically most efficient when the error distribution is unknown. However, the practical relevance of their method remains to be evaluated. Further, although some parameters in several common duration models are known to be nonnegative, this estimator may turn out to be negative. This paper addresses these two issues. We propose a new semiparametric estimator when there are inequality constraints on parameters, and a simulation study evaluates the two semiparametric estimators. The results lead us to conclude the following when the error distribution is unknown: (i) If there are no inequality constraints on parameters then the Drost-Werker estimator is better than the QMLE, and (ii) if there are inequality constraints on parameters then the estimator proposed in this paper is better than the Drost-Werker estimator and the QMLE. In conclusion, this paper recommends estimators that are better than the often used QMLE for estimating duration models.
title: Properties of a model of sequential random allocation
Creators: name: Stewart, Laura
Publisher: name: University of Glasgow
Year: 2023

description: Probabilistic models of allocating shots to boxes according to a certain probability distribution have commonly been used for processes involving agglomeration. Such processes are of interest in many areas of research such as ecology, physiology, chemistry and genetics. Time could be incorporated into the shots-and-boxes model by considering multiple layers of boxes through which the shots move, where the layers represent the passing of time. Such a scheme with multiple layers, each with a certain number of occupied boxes is naturally associated with a random tree. It lends itself to genetic applications where the number of ancestral lineages of a sample changes through the generations. This multiple-layer scheme also allows us to explore the difference in the number of occupied boxes between layers, which gives a measure of how quickly merges are happening. In particular, results for the multiple-layer scheme corresponding to those known for a single-layer scheme, where, under certain conditions, the limiting distribution of the number of occupied boxes is either Poisson or normal, are derived. To provide motivation and demonstrate which methods work well, a detailed study of a small, finite example is provided. A common approach for establishing a limiting distribution for a random variable of interest is to first show that it can be written as a sum of independent Bernoulli random variables as this then allows us to apply standard central limit theorems. Additionally, it allows us to, for example, provide an upper bound on the distance to a Poisson distribution. One way of showing that a random variable can be written as a sum of independent Bernoulli random variables is to show that its probability generating function (p.g.f.) has all real roots. Various methods are presented and considered for proving the p.g.f. of the number of occupied boxes in any given layer of the scheme has all real roots. By considering small finite examples some of these methods could be ruled out for general N. Finally, the scheme for general N boxes and n shots is considered, where again a uniform allocation of shots is used. It is shown that, under certain conditions, the distribution of the number of occupied boxes tends towards either a normal or Poisson limit. Equivalent results are also demonstrated for the distribution of the difference in the number of occupied boxes between consecutive layers.
Using synchronous Boolean networks to model several phenomena of collective behavior
Creators: name: Kochemazov, Stepan
name: Semenov, Alexander
Publisher: name: arXiv
Year: 2014
Subjects: subject: Social and Information Networks (cs.SI)
subject: Artificial Intelligence (cs.AI)
subject: Multiagent Systems (cs.MA)
subject: FOS: Computer and information sciences

description: In this paper, we propose an approach for modeling and analysis of a number of phenomena of collective behavior. By collectives we mean multi-agent systems that transition from one state to another at discrete moments of time. The behavior of a member of a collective (agent) is called conforming if the opinion of this agent at current time moment conforms to the opinion of some other agents at the previous time moment. We presume that at each moment of time every agent makes a decision by choosing from the set {0,1} (where 1-decision corresponds to action and 0-decision corresponds to inaction). In our approach we model collective behavior with synchronous Boolean networks. We presume that in a network there can be agents that act at every moment of time. Such agents are called instigators. Also there can be agents that never act. Such agents are called loyalists. Agents that are neither instigators nor loyalists are called simple agents. We study two combinatorial problems. The first problem is to find a disposition of instigators that in several time moments transforms a network from a state where a majority of simple agents are inactive to a state with a majority of active agents. The second problem is to find a disposition of loyalists that returns the network to a state with a majority of inactive agents. Similar problems are studied for networks in which simple agents demonstrate the contrary to conforming behavior that we call anticonforming. We obtained several theoretical results regarding the behavior of collectives of agents with conforming or anticonforming behavior. In computational experiments we solved the described problems for randomly generated networks with several hundred vertices. We reduced corresponding combinatorial problems to the Boolean satisfiability problem (SAT) and used modern SAT solvers to solve the instances obtained.
Hsp 70/Hsp 90 organizing protein as a nitrosylation target in cystic fibrosis therapy
Creators: name: Islam, R.
name: Yemen, S.
name: Plapp, M.
name: Sun, F.
name: Clapp, P. W.
name: Erdmann-Gilmore, P.
name: Zaman, K.
name: Marozkina, N. V.
name: Liu, L.
name: Borowitz, M.
name: Randell, S. H.
name: Gaston, B.
name: Mantri, S.
name: Townsend, R. R.
name: Lichti, C. F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The endogenous signaling molecule S-nitrosoglutathione (GSNO) and other S-nitrosylating agents can cause full maturation of the abnormal gene product ΔF508 cystic fibrosis (CF) transmembrane conductance regulator (CFTR). However, the molecular mechanism of action is not known. Here we show that Hsp70/Hsp90 organizing protein (Hop) is a critical target of GSNO, and its S-nitrosylation results in ΔF508 CFTR maturation and cell surface expression. S-nitrosylation by GSNO inhibited the association of Hop with CFTR in the endoplasmic reticulum. This effect was necessary and sufficient to mediate GSNO-induced cell-surface expression of ΔF508 CFTR. Hop knockdown using siRNA recapitulated the effect of GSNO on ΔF508 CFTR maturation and expression. Moreover, GSNO acted additively with decreased temperature, which promoted mutant CFTR maturation through a Hop-independent mechanism. We conclude that GSNO corrects ΔF508 CFTR trafficking by inhibiting Hop expression, and that combination therapies—using differing mechanisms of action—may have additive benefits in treating CF.
Human tumor virus utilizes exosomes for intercellular communication
Creators: name: Kung, C.-P.
name: Meckes, D. G.
name: Shair, K. H. Y.
name: Raab-Traub, N.
name: Edwards, R. H.
name: Marquitz, A. R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The Epstein–Barr virus (EBV) latent membrane protein 1 (LMP1) is expressed in multiple human malignancies and has potent effects on cell growth. It has been detected in exosomes and shown to inhibit immune function. Exosomes are small secreted cellular vesicles that contain proteins, mRNAs, and microRNAs (miRNAs). When produced by malignant cells, they can promote angiogenesis, cell proliferation, tumor-cell invasion, and immune evasion. In this study, exosomes released from nasopharyngeal carcinoma (NPC) cells harboring latent EBV were shown to contain LMP1, signal transduction molecules, and virus-encoded miRNAs. Exposure to these NPC exosomes activated the ERK and AKT signaling pathways in the recipient cells. Interestingly, NPC exosomes also contained viral miRNAs, several of which were enriched in comparison with their intracellular levels. LMP1 induces expression of the EGF receptor in an EBV-negative epithelial cell line, and exosomes produced by these cells also contain high levels of EGF receptor in exosomes. These findings suggest that the effects of EBV and LMP1 on cellular expression also modulate exosome content and properties. The exosomes may manipulate the tumor microenvironment to influence the growth of neighboring cells through the intercellular transfer of LMP1, signaling molecules, and viral miRNAs.
Tying Spitzer's IRS Calibration to IRAC: Observations of IRS Standard Stars
Creators: name: Kraemer, Kathleen E.
name: Engelke, Charles W.
name: Renger, Bailey A.
name: Sloan, G. C.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present 3.6 and 4.5 um photometry for a set of 61 standard stars observed by Spitzer's Infrared Spectrograph (IRS). The photometry was obtained with the Infrared Array Camera (IRAC) on Spitzer in order to help tie the calibration of IRAC and the IRS, which had been anchored to the calibration of the Multiband Infrared Photometer for Spitzer (MIPS). The wavelength range of the IRS data only slightly overlaps with the IRAC 4.5 um band and not at all with the 3.6 um band. Therefore, we generated synthetic spectra from spectral templates of stars with the same spectral types and luminosity classes as our sample stars, normalized to the IRS data at 6-7 um, and compared those to the observed photometry. The new IRAC observations of IRS standard stars demonstrate that the two instruments are calibrated to within 1% of each other.
title: Atteinte axiale dans le rhumatisme psoriasique
title: Atteinte axiale dans le rhumatisme psoriasique
Creators: name: Erraoui, Mariam
Publisher: name: Revue Marocaine de Rhumatologie (RMR)
Year: 2023
Subjects: Rhumatisme psoriasique, atteinte axiale

description: The Axial psoriatic arthritis is a clinical form of psoriatic arthritis. Its diagnosis is based on clinical signs and imaging generally referring to ankylosing spondylitis. This poses a problem of definition of this entity, and of its particularity in relation to ankylosing spondylitis. In this update, we will discuss the clinical, genetic, imaging and therapeutic characteristics of axial involvement in psoriatic arthritis. Towards the end we will touch a word on perspectives.
description: Le rhumatisme psoriasique axial est une forme clinique du rhumatisme psoriasique. Son diagnostic repose sur des signes cliniques et imagerie faisant en général référence à la spondylarthrite ankylosante. Ceci pose un problème de définition de cette entité, et de sa particularité par rapport à la spondylarthrite ankylosante. Nous aborderons dans cette mise au point les caractéristiques cliniques, génétiques, imagerie et thérapeutiques de l’atteinte axiale du rhumatisme psoriasique. Vers la fin nous toucherons un mot sur les perspectives.
title: Bridging Ancient Artistry and Modern Engineering: a 3D-Printed Concrete Arch Bridge Inspired by Millennium-Old Bronze Patterns Using an Integrated Concrete 3D Printing System
Creators: name: Yang, Min
name: Yao, Xiaofei
name: Zhao, Liguo
name: Zhang, Yamei
name: Wang, Zuo
name: Wang, Xuejun
name: Ding, Xiaojun
name: Bai, Songlin
name: Liu, Shilong
Publisher: name: Universitätsbibliothek Braunschweig
Year: 2024
Subjects: subject: Concrete 3D Printing
subject: Arch Bridge
subject: Modular Construction Strategy
subject: Real-Time Cooperative Control
subject: 62

description: This study unveils an unprecedented blend of ancient cultural motifs and contemporary engineering through the design and construction of a 3D-printed concrete arch bridge. Our approach involves four key phases: System Development for 3D Concrete Printing: We developed a state-of-the-art system facilitating real-time surveillance and parameter modulation during the printing process. Cultural Integration in Design: The bridge design incorporates patterns extracted from ancient bronze artworks, blending historical significance with modern structural design. Modular Construction Strategy: The bridge's architec-ture is segmented into primary components; each segment is assigned a unique identifier, modeled in 3D, and printed separately. Systematic Assembly and Val-idation: Following the printing phase, components are assembled on-site in a numbered sequence. Post-assembly, the bridge undergoes load testing to ascer-tain its structural integrity and compliance with safety standards. This project not only demonstrates the practicality of constructing intricate structures via 3D concrete printing but also highlights the potential for incorporating traditional art into contemporary engineering designs. The successful merging of millennia-old patterns with advanced construction methods marks a significant step forward in architectural engineering, showcasing a novel paradigm in the fusion of histori-cal artistry and modern technology.
description: Digital Concrete 2024 - Supplementary Proceedings
Modelling Atmospheric Erosion for Terrestrial Planets in the Solar System
Creators: name: Alonso Tagle, Maria Luisa
name: Maggiolo, Romain
name: Gunell, Herbert
name: De Keyser, Johan
name: Cessateur, Gaël
name: Lapenta, Giovanni
name: Pierrard, Viviane
name: Vandaele, Ann Carine
Publisher: name: Zenodo
Year: 2023

description: Since the Great Oxidation Event, the oxygen escape rate on Earth has changed over time mainly due to solar evolution. Two solar agents drive the Earth’s atmospheric erosion rate: the solar wind and the EUV radiation. The first one affects the non-thermal processes by changing the plasma conditions, and the second one affects both types of processes: by increasing the atmospheric temperature, and by modifying the ion production rate. Hence EUV radiation affects atmospheric parameters, such as the exobase distance and neutral density, which influence the escape rate. In this work, we describe a model that uses in-situ measurements and physical considerations to estimate the effect of solar evolution on the atmospheric loss rate. Physical assumptions are made to describe the contribution of the solar wind pressure on each erosion mechanism. The main objective is to reproduce earlier solar conditions to constrain oxygen loss over geological time scales. Seven different mechanisms are studied, to determine the fundamental factors that have a significant impact on the oxygen escape rate in the past Earth. We discuss the effects of the exospheric parameters and solar wind drivers on the oxygen erosion rate. We examine their relevance for total oxygen loss and their influence on the stability of our atmosphere.
CoreTrustSeal Trustworthy Data Repositories Requirements: Begrippenlijst 2023-2025. Nederlandse vertaling
Creators: name: Data Archiving And Networked Services (DANS-KNAW)
Publisher: name: Zenodo
Year: 2022
Subjects: CoreTrustSeal
Certification
Translation
Glossary
Begrippenlijst
Certificering
Trustworthy Digital Repositories

description: Dit document is een Nederlandse vertaling van 'CoreTrustSeal Trustworthy Data Repositories Requirements: Glossary 2023-2025' (https://doi.org/10.5281/zenodo.7051125), gecreëerd door DANS ten behoeve van de Wegwijzer Certificering (https://wegwijzercertificering.nl/nl). De Wegwijzer Certificering is een voorziening van het Netwerk Digitaal Erfgoed, geborgd door DANS, die ondersteuning biedt aan erfgoedinstellingen om aan de slag te gaan met de certificering van hun archief. De Nederlandse vertaling van de CoreTrustSeal documenten kan worden gebruikt in het aanmeldingsproces om de Requirements beter te begrijpen in de eigen context.
description: NB: Dit document is niet door CoreTrustSeal gecreëerd en is daarom niet leidend. De originele CoreTrustSeal documentatie is de enige gezaghebbende (https://doi.org/10.5281/zenodo.7051125). Aanmeldingen voor CoreTrustSeal certificering dienen in het Engels ingediend te worden.