cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Research priorities in advanced heart failure: James Lind alliance priority setting partnership
Creators: name: Taylor, Clare J
name: Huntley, Alyson L
name: Burden, John
name: Gadoud, Amy
name: Gronlund, Toto
name: Jones, Nicholas Robert
name: Wicks, Eleanor
name: McKelvie, Sara
name: Byatt, Kit
name: Lehman, Richard
name: King, Anna
name: Mumford, Bev
name: Feder, Gene
name: Mant, Jonathan
name: Hobbs, Richard
name: Johnson, Rachel
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Heart failure and cardiomyopathies
1506
heart failure
EBM
heart failure treatment
quality of care and outcomes

description: Objective: To determine research priorities in advanced heart failure (HF) for patients, carers and healthcare professionals. Methods: Priority setting partnership using the systematic James Lind Alliance method for ranking and setting research priorities. An initial open survey of patients, carers and healthcare professionals identified respondents’ questions, which were categorised to produce a list of summary research questions; questions already answered in existing literature were removed. In a second survey of patients, carers and healthcare professionals, respondents ranked the summary research questions in order of priority. The top 25 unanswered research priorities were then considered at a face-to-face workshop using nominal group technique to agree on a ‘top 10’. Results: 192 respondents submitted 489 responses each containing one or more research uncertainty. Out-of-scope questions (35) were removed, and collating the responses produced 80 summary questions. Questions already answered in the literature (15) were removed. In the second survey, 65 questions were ranked by 128 respondents. The top 10 priorities were developed at a consensus meeting of stakeholders and included a focus on quality of life, psychological support, the impact on carers, role of the charity sector and managing prognostic uncertainty. Ranked priorities by physicians and patients were remarkably divergent. Conclusions: Engaging stakeholders in setting research priorities led to a novel set of research questions that might not have otherwise been considered. These priorities can be used by researchers and funders to direct future research towards the areas which matter most to people living with advanced HF.
title: Distributed fiber optical sensing of oxygen with optical time domain reflectometry
Creators: name: Eich, Susanne
name: Schmälzlin, Elmar
name: Löhmannsröben, Hans-Gerd
Publisher: name: Universität Potsdam
Year: 2021
Subjects: subject: 620 Ingenieurwissenschaften und zugeordnete Tätigkeiten

description: In many biological and environmental applications spatially resolved sensing of molecular oxygen is desirable. A powerful tool for distributed measurements is optical time domain reflectometry (OTDR) which is often used in the field of telecommunications. We combine this technique with a novel optical oxygen sensor dye, triangular-[4] phenylene (TP), immobilized in a polymer matrix. The TP luminescence decay time is 86 ns. The short decay time of the sensor dye is suitable to achieve a spatial resolution of some meters. In this paper we present the development and characterization of a reflectometer in the UV range of the electromagnetic spectrum as well as optical oxygen sensing with different fiber arrangements.
description: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe; 1085
Rappia horstockii Boul.
Creators: name: Müller, F
Publisher: name: Zenodo
Year: 1885
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Amphibia
Anura
Hylidae
Rappia
Rappia horstockii

description: * Rappia horstockii Boul. eat.
S.-Africa. v. F M. [1]
description: Published as part of Müller, F, 1885, Vierter Nachtrag zum Katalogder herpetologischen Sammlung des Basler Museums, pp. 668-717 in Verhandlungen der Naturforschenden Gesellschaft in Basel. 7 (3) on page 671, DOI: 10.5962/bhl.part.2388, http://zenodo.org/record/15183591
Fingerprinting dark energy
Creators: name: Sapone, Domenico
name: Kunz, Martin
Publisher: name: arXiv
Year: 2009
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Dark energy perturbations are normally either neglected or else included in a purely numerical way, obscuring their dependence on underlying parameters like the equation of state or the sound speed. However, while many different explanations for the dark energy can have the same equation of state, they usually differ in their perturbations so that these provide a fingerprint for distinguishing between different models with the same equation of state. In this paper we derive simple yet accurate approximations that are able to characterize a specific class of models (encompassing most scalar-field models) which is often generically called "dark energy". We then use the approximate solutions to look at the impact of the dark energy perturbations on the dark matter power spectrum and on the integrated Sachs-Wolfe effect in the cosmic microwave background radiation.
description: 11 pages, 5 figures, minor changes to match published version
LE CORTI MARZIALI DI SALO'. IL TRIBUNALE MILITARE REGIONALE DI GUERRA DI MILANO (1943-1945)
Creators: name: TIEGHI, SAMUELE
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: THE COURTS-MARTIAL OF SALO ' THE REGIONAL MILITARY COURT OF MILAN (1943-1945) THE RESEARCH INTENDS TO HIGHLIGHT THE WORK DONE BY THE REGIONAL MILITARY COURT OF MILAN DURING THE HISTORICAL PERIOD OF THE ITALIAN SOCIAL REPUBLIC, IN PARTICULAR TO THE COURT PROCEEDINGS FILED REGARDING THE CASES OF DESERTION AND ABSENCE WITHOUT LEAVE TO MILITARY SERVICE . HOWEVER, RESEARCH CONCERNS MORE BROAD TOPICS BASED ON THREE DIFFERENT LEVELS: A)THE OPERATION OF MILITARY JUSTICE IN THE ITALIAN SOCIAL REPUBLIC B)JUDICIAL ACTION OF CRIMES TO THE JURISDICTION OF THE COURTS OF REGIONAL MILITARY C)THE CASE OF THE REGIONAL MILITARY COURT IN MILAN THROUGH THE FUNDS DEPOSITED AT THE STATE ARCHIVES OF MILAN.
Map #51, Site 5MT2032, Pithouse 110, Surface 1
Creators: name: DeVos, Jim
Year: 2018
Subjects: subject: Southwestern Colorado
valueUri: https://core.tdar.org/browse/geographic-keyword/2810/southwestern-colorado
subject: Southwestern US
valueUri: https://core.tdar.org/browse/geographic-keyword/84604/southwestern-us
subject: Basketmaker III
valueUri: https://core.tdar.org/browse/temporal-keyword/78/basketmaker-iii
subject: 5MT2032
valueUri: https://core.tdar.org/browse/site-name/118020/5mt2032
subject: Switchback site
valueUri: https://core.tdar.org/browse/site-name/118019/switchback-site

description: Site 5MT2032, Pithouse 110, Surface 1
Optimization-based configuration of engineer-to-order products
Creators: name: Vidner, Olle
name: Wiberg, Anton
name: Pettersson, Robert
name: Persson, Johan A.
name: Ölvander, Johan
Publisher: name: Zenodo
Year: 2023

description: -
description: Funded by Stiftelsen tekn.dr. Erik Johnssons stipendiefond
Map #72, Site 5MT10631, Topography
Creators: name: DeVos, Jim
Year: 2019
Subjects: subject: Southwestern Colorado
valueUri: https://core.tdar.org/browse/geographic-keyword/2810/southwestern-colorado
subject: Southwestern US
valueUri: https://core.tdar.org/browse/geographic-keyword/84604/southwestern-us
subject: Basketmaker III
valueUri: https://core.tdar.org/browse/temporal-keyword/78/basketmaker-iii
subject: Pueblo II
valueUri: https://core.tdar.org/browse/temporal-keyword/55/pueblo-ii
subject: 5MT10631
valueUri: https://core.tdar.org/browse/site-name/118036/5mt10631
subject: Mueller Little House
valueUri: https://core.tdar.org/browse/site-name/118035/mueller-little-house

description: Site 5MT10631, Topography
Mutational characterization of HBV reverse transcriptase gene and the genotype-phenotype correlation of antiviral resistance among Chinese chronic hepatitis B patients
Creators: name: Fu, Ya
name: Wu, Songhang
name: Hu, Yuhai
name: Chen, Tianbin
name: Zeng, Yongbin
name: Liu, Can
name: Ou, Qishui
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology
subject: Computational Biology

description: Background and Aims: The drug resistance of hepatitis B virus (HBV) originates from mutations within HBV reverse transcriptase (RT) region during the prolonged antiviral therapy. So far, the characteristics of how these mutations distribute and evolve in the process of therapy have not been clarified yet. Thus we aimed to investigate these characteristics and discuss their contributing factors. Methods: HBV RT region was direct-sequenced in 285 treatment-naive and 214 post-treatment patients. Mutational frequency and Shannon entropy were calculated to identify the specific mutations differing between genotypes or treatment status. A typical putative resistance mutation rtL229V was further studied using in-vitro susceptibility assays and molecular modeling. Results: The classical resistance mutations were rarely detected among treatment-naive individuals, while the putative resistance mutations were observed at 8 AA sites. rtV191I and rtA181T/V were the only resistance mutations identified as genotype-specific mutation. Selective pressure of drug usage not only contributed to the classical resistance mutations, but also induced the changes at a putative resistance mutation site rt229. rtL229V was the major substitution at the site of rt229. It contributed to the most potent suppression of viral replication and reduced the in-vitro drug susceptibility to entecavir (ETV) when coexisting with rtM204V, consistent with the hypothesis based on the molecular modeling and clinical data analysis. Conclusions: The analysis of mutations in RT region under the different circumstances of genotypes and therapy status might pave the way for a better understanding of resistance evolution, thus providing the basis for a rational administration of antiviral therapy.
Freedom and addiction in four discursive registers: A comparative historical study of values in addiction science
Creators: name: Weinberg, Darin
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Articles
addiction
freedom
history
science
values

description: Mainstream addiction science is today widely marked by an antinomy between a neurologically determinist understanding of the human brain ‘hijacked’ by the biochemical allure of intoxicants and a liberal voluntarist conception of drug use as a free exercise of choice. Prominent defenders of both discourses strive, ultimately without complete success, to provide accounts that are both universal and value-neutral. This has resulted in a variety of conceptual problems and has undermined the utility of such research for those who seek to therapeutically care for people presumed to suffer from addictions. This article contrasts these two contemporary discourses to two others that played vital historical roles in initiating both scientific and popular concern for addiction. These are the Puritan and civic republican discourses that dominated scholarly discussions of addiction in the early modern era. In each case, the place of values in these discussions is highlighted. By comparing them to their early modern historical antecedents, this article seeks to reflexively explore and develop more intellectually sound and therapeutically relevant alternatives to the troubled attempts at universality and value-neutrality now fettering debates in mainstream addiction science.
Collective excitation frequencies and stationary states of trapped dipolar Bose-Einstein condensates in the Thomas-Fermi regime
Creators: name: van Bijnen, R. M. W.
name: Parker, N. G.
name: Kokkelmans, S. J. J. M. F.
name: Martin, A. M.
name: O'Dell, D. H. J.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We present a general method for obtaining the exact static solutions and collective excitation frequencies of a trapped Bose-Einstein condensate (BEC) with dipolar atomic interactions in the Thomas-Fermi regime. The method incorporates analytic expressions for the dipolar potential of an arbitrary polynomial density profile, thereby reducing the problem of handling non-local dipolar interactions to the solution of algebraic equations. We comprehensively map out the static solutions and excitation modes, including non-cylindrically symmetric traps, and also the case of negative scattering length where dipolar interactions stabilize an otherwise unstable condensate. The dynamical stability of the excitation modes gives insight into the onset of collapse of a dipolar BEC. We find that global collapse is consistently mediated by an anisotropic quadrupolar collective mode, although there are two trapping regimes in which the BEC is stable against quadrupole fluctuations even as the ratio of the dipolar to s-wave interactions becomes infinite. Motivated by the possibility of fragmented BEC in a dipolar Bose gas due to the partially attractive interactions, we pay special attention to the scissors modes, which can provide a signature of superfluidity, and identify a long-range restoring force which is peculiar to dipolar systems. As part of the supporting material for this paper we provide the computer program used to make the calculations, including a graphical user interface.
description: 23 pages, 11 figures
Rural Zoning in the United States
Creators: name: Solberg, Erling D.
name: Solberg, Erling D.
Publisher: name: Unknown
Year: 1952
Subjects: Agricultural and Food Policy
Community/Rural/Urban Development
Land Economics/Use

description: Excerpt from the report: This publication summarizes the main rural zoning powers now conferred on counties, on towns and townships, and on miscellaneous local governments by rural-zoning enabling statutes of the 38 States that have enacted such laws. Further, it shows the manner and the extent to which the powers granted in the enabling laws were exercised in slightly more than 40 percent of the 173 county rural-zoning ordinances in effect when the study was made. Town and township zoning ordinances were not examined; and zoning in incorporated cities, towns, and villages is not included. Data on rural-zoning enabling laws are for the period ending January 1951, and those relating to county zoning ordinances are for the period ending May 1949.
Open data and open-source tools throughout research data life cycle: KCDC example
Creators: name: Tokareva, V.
Publisher: name: Zenodo
Year: 2023
Subjects: astroparticle physics
cosmic rays
research data management
KCDC
PUNCH4NFDI
FAIR data
open data
data life cycle
data center
outreach

description: Open science essentials include open data, open source software, open access materials, open educational resources, etc. They provide substantial benefits to society like reproducibility of research, increased transparency and public acceptance of studies, simplified publication process, and enhanced public education. Ultimately, new opportunities become available for unique interdisciplinary studies performed by large diverse teams of specialists on publicly available datasets. Established in 2013, the KASCADE Cosmic Ray Data Centre (KCDC) exists simultaneously as an open archive for data of high-energy astroparticle physics experiments (such as KASCADE, KASCADE-Grande, LOPES, Maket-Ani, etc.), open source software and a web portal providing access to open educational resources. KCDC allows data selection with custom user data cuts using GUI or REST API and interactive online analysis of the selected data with integrated Jupyter Notebooks. From this talk, one can learn more about KCDC's functionality and get better understanding of open science and research data life cycle concepts. An example of machine learning based analysis employing the KCDC platform and deployment of the results as an application using Streamlit will be discussed. This work is partially supported by the DFG fund ``NFDI 39/1" for the PUNCH4NFDI consortium.
description: V. Tokareva for KCDC Team
Die Bedeutung von Lehrpreisen für Preisträger*innen und ihr Beitrag zur Lehrentwicklung - Befunde der Schweizer Lehrpreisstudie
Creators: name: Scheidig, Falk
name: Tremp, Peter
Publisher: name: Zenodo
Year: 2020
Subjects: Lehrpreise
Role Model
Lehrentwicklung
akademische Reputation

description: Lehrpreise haben sich auch im deutschen Sprachraum weitgehend etabliert. Welche Bedeutung schreiben Träger*innen eines Lehrpreises dieser Auszeichnung zu? Wurden sie eingeladen, ihre Lehrexpertise weiterzugeben – und sind sie dazu überhaupt bereit? Der Beitrag präsentiert ausgewählte Befunde einer Schweizer Lehrpreisstudie und diskutiert sowohl die individuelle Bedeutung von Lehrpreisen also auch den Beitrag von Lehrpreisen zur institutionellen Lehrentwicklung.
description: + ID der Publikation: phlu_12837 + Art des Beitrages: Buchkapitel/Beitrag in Sammelband + Seiten: 59 - 81 + Nummer des Reihentitels: 4 + Sprache: Deutsch + Bemerkungen: Rückfragen: sandra.betschart@phlu.ch + Letzte Aktualisierung: 2021-01-11 17:35:48
Water jet impingement in run-out table cooling
Creators: name: Alakbari, Abdullah Al
Publisher: name: University of British Columbia
Year: 2023

description: cooling process on a run-out table is a critical step that governs the final microstructure and the mechanical properties of the produced steels. In this research, we use a more recent method for obtaining the thermal history on the plate surface, which is the infrared thermal imaging technique. This technique has the advantage of capturing the surface temperature history remotely and with no contact with the plate. In this work, controlled cooling experiments under transient conditions were conducted on a hot stationary plate using an impinging top circular nozzle and a thermal camera to capture the temperature history. The measurements from the thermal camera (conducted in Abu Dhabi University) are compared with the conventional thermocouple measurements (University of British Columbia). The comparisons showed that the infrared camera gives more complete picture of the thermal history and more accurate results than thermocouple measurements. Reasons for the inaccuracy of the thermocouple (T/C) measurements include T/C response time, and distortion of the thermal field by the method of installation. These reasons are discussed in detail in the thesis. Additionally, we introduce a transient multiphase CFD numerical simulation to obtain the temperature profile on the plate surface and compare it with the experiments conducted. The numerical simulation was done using the Ansys-Fluent CFD software. A two-dimensional model was used with a highly intensive mesh near the wall region based on the wall y+ number. The surface temperature graphs for both measurements and simulation are compared at different radial locations (stagnation zone and parallel zone). Additionally, the obtained CFD results were verified and compared with the surface temperature of the experimental data.
Teaching clinicians shared decision making and risk communication online: an evaluation study
Creators: name: Hoffmann, Tammy C
name: Del Mar, Chris
name: Santhirapala, Ramai
name: Freeman, Alexandra
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Original research
1506

description: Objectives: To describe the development and initial evaluation of a brief e-learning course as a means of teaching shared decision making and risk communication skills to clinicians of all specialties. Design: Comparison pre-course and post-course of scores in subjective confidence and objective knowledge about shared decision making and risk communication. Setting: Online and open to all specialties and levels of clinical experience, including students. Participants: The course is freely available online and all who started the course from September 2018 to May 2020 were invited to participate in the evaluation study. Intervention: The self-guided e-learning course is made up of four modules and takes approximately 2 hours to complete. It is hosted on the website of the Winton Centre for Risk Communication and the UK’s National Health Service e-learning platform. Main outcome measures: Pre-course and post-course confidence in performing shared decision making (as measured by a 10-item scale adapted from the OPTION tool; total score range 10–50), and objective knowledge about basic principles of shared decision making and risk communication, as measured by performance on four knowledge questions and three calculations. At course commencement, a single item from the Berlin Numeracy Test, and the eight-item Subjective Numeracy Test were also asked. Results: Of 366 unique participants who consented and commenced the course, 210 completed all modules and the final post-course test. Participants’ mean age was 38.1 years, 69% were in current clinical practice and had a mean of 10.5 years of clinical practice. Numeracy was relatively low, with 50.7% correctly answering the Berlin Numeracy Test item pre-course. Participants who completed the course showed a significant improvement in their confidence by a mean summed score of 3.7 units (95% CI 2.9 to 4.6, p<0.0001) from a mean pre-course of 37.4 (SD 6.1) to post-course of 41.1 (SD 6.9). There was an increase in the proportion of correct answers for most knowledge questions (p<0.0001, p=0.013 for two directly compared), although no improvement in most skill questions that involved numbers (eg, calculating relative risks). Participants with higher numeracy appeared to show higher skill and confidence on most questions. Conclusions: This online, free e-learning course was successful in increasing participants’ confidence in, and some aspects of knowledge about, shared decision making and risk communication. It also highlighted the need for improvements in clinicians’ numerical skills as a vital part of training. We suggest that the course is used in combination with practical face-to-face experience and more intensive numerical skills training.
Ability of fabric face mask materials to filter ultrafine particles at coughing velocity
Creators: name: O'Kelly, Eugenia
name: Pirog, Sophia
name: Ward, James
name: Clarkson, P John
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Public health
1506
2474
1724
public health
infection control
respiratory infections
infectious diseases

description: Objective: We examined the ability of fabrics which might be used to create home-made face masks to filter out ultrafine (0.02–0.1 µm) particles at the velocity of adult human coughing. Methods: Twenty commonly available fabrics and materials were evaluated for their ability to reduce air concentrations of ultrafine particles at coughing face velocities. Further assessment was made on the filtration ability of selected fabrics while damp and of fabric combinations which might be used to construct home-made masks. Results: Single fabric layers blocked a range of ultrafine particles. When fabrics were layered, a higher percentage of ultrafine particles were filtered. The average filtration efficiency of single layer fabrics and of layered combination was found to be 35% and 45%, respectively. Non-woven fusible interfacing, when combined with other fabrics, could add up to 11% additional filtration efficiency. However, fabric and fabric combinations were more difficult to breathe through than N95 masks. Conclusions: The current coronavirus pandemic has left many communities without access to N95 face masks. Our findings suggest that face masks made from layered common fabric can help filter ultrafine particles and provide some protection for the wearer when commercial face masks are unavailable.
Angular instability due to radiation pressure in the LIGO gravitational wave detector
Creators: name: Hirose, Eiichi
name: Kawabe, Keita
name: Sigg, Daniel
name: Adhikari, Rana
name: Saulson, Peter R.
Publisher: name: arXiv
Year: 2009
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We observed the effect of radiation pressure on the angular sensing and control system of the Laser Interferometer Gravitational-Wave Observatory (LIGO) interferometer's core optics at LIGO Hanford Observatory. This is the first measurement of this effect in a complete gravitational wave interferometer. Only one of the two angular modes survives with feedback control, since the other mode is suppressed when the control gain is sufficiently large. We developed a mathematical model to understand the physics of the system. This model matches well the dynamics that we observe.
description: Submitted to Applied Optics
The role of self-reported hearing status in the risk of hospitalisation among Chinese middle-aged and older adults
Creators: name: Ye, Xin
name: Zhu, Dawei
name: He, Ping
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Mental Health

description: To determine the association between self-reported hearing status and risk of hospitalisation among Chinese middle-aged and older adults. Prospective cohort study. Discrete-time hazards models and negative binomial models were fitted to examine the relationship. About 11,902 participants aged 45 years or older with no hospitalisation at baseline. 49.28–62.70% of the participants reported their hearing as fair or poor. For older adults aged 60 and above, compared to people with excellent and very good hearing, those with good, fair or poor hearing reported shorter time to first hospitalisation [hazard ratio (HR) = 1.38, 1.38, 1.63, respectively]. They also manifested greater number of hospitalisations [incident rate ratio (IRR) = 1.21, 1.25, 1.54, respectively], and longer duration of hospitalisation (IRR = 1.36, 1.26, 1.53, respectively). However, there was no significant association between hearing status and hospitalisation for middle-aged adults for none of the hearing categories. Although no significant relationship between hearing and hospitalisation was found for middle-aged adults, older adults with poorer hearing experienced greater risk of hospitalisation. Given that hearing impairment is highly prevalent among older adults, future analyses are needed to investigate whether hearing rehabilitative therapies could help mitigate hospitalisations in hearing-impaired older adults.
Probing Local Variations of Superconductivity on the Surface of Ba(Fe1-xCox)2As2 Single Crystals
Creators: name: Kim, T. -H.
name: Jin, R.
name: Walker, L. R.
name: Howe, J. Y.
name: Pan, M. H.
name: Wendelken, J. F.
name: Thompson, J. R.
name: Sefat, A. S.
name: McGuire, M. A.
name: Sales, B. C.
name: Mandrus, D.
name: Li, A. P.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The spatially resolved electrical transport properties have been studied on the surface of optimally-doped superconducting Ba(Fe1-xCox)2As2 single crystal by using a four-probe scanning tunneling microscopy. While some non-uniform contrast appears near the edge of the cleaved crystal, the scanning electron microscopy (SEM) reveals mostly uniform contrast. For the regions that showed uniform SEM contrast, a sharp superconducting transition at TC = 22.1 K has been observed with a transition width (delta)Tc = 0.2 K. In the non-uniform contrast region, TC is found to vary between 19.6 and 22.2 K with (delta)Tc from 0.3 to 3.2 K. The wavelength dispersive x-ray spectroscopy reveals that Co concentration remains 7.72% in the uniform region, but changes between 7.38% and 7.62% in the non-uniform region. Thus the variations of superconductivity are associated with local compositional change.
description: 18 pages, 5 figures
Map #57, Site 5MT2032, Pit Room 113, Nonstructure 114, and Arbitrary Unit 208, Stratigraphic Profile
Creators: name: DeVos, Jim
Year: 2017
Subjects: subject: Southwestern Colorado
valueUri: https://core.tdar.org/browse/geographic-keyword/2810/southwestern-colorado
subject: Southwestern US
valueUri: https://core.tdar.org/browse/geographic-keyword/84604/southwestern-us
subject: Basketmaker III
valueUri: https://core.tdar.org/browse/temporal-keyword/78/basketmaker-iii
subject: 5MT2032
valueUri: https://core.tdar.org/browse/site-name/118020/5mt2032
subject: Switchback site
valueUri: https://core.tdar.org/browse/site-name/118019/switchback-site

description: Site 5MT2032, Pit Room 113, Nonstructure 114, and Arbitrary Unit 208, Stratigraphic Profile
Birth weight, family history of diabetes and diabetes onset in schizophrenia
Creators: name: Fernandez-Egea, Emilio
name: Walker, Ryan
name: Ziauddeen, Hisham
name: Cardinal, Rudolf N
name: Bullmore, Edward T
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Cardiovascular and Metabolic Risk
1506
1870
clozapine
development
psychiatry

description: Introduction: The prevalence of diabetes in schizophrenia is twice that in the general population, but there are few reliable predictors of which individuals will develop glucose dysregulation. Objective: To test if abnormal birth weight (either too low or too high) and parental diabetes, both variables that can be ascertained in the clinic, can predict diabetes onset in patients with schizophrenia. Research design and methods: Electronic records of a cohort of 190 clozapine-treated patients (37% treated for more than 20 years) and Cox regression survival analysis (with any type of glucose dysregulation as the event) to account for differences in length of treatment before the event and age at clozapine treatment initiation. Results: Age at clozapine initiation (Exp(B)=1.098; p<0.001), family history of diabetes (Exp(B)=2.299; p=0.049) and birth weight2 (Exp(B)=0.999; p=0.013) were significant predictors of glucose dysregulation onset, while gender was not (Exp(B)=0.1.350; p=0.517). Among individuals with 10 years of follow-up, 80% of those with both abnormal birth weight and a family history of diabetes developed diabetes compared with 56% with only abnormal birth weight, 40% with only a family history of diabetes and 20% in those with neither. Conclusions: Since 48% of cases had at least one risk factor and 6% had both risk factors, there is a substantial proportion of patients for whom preventive strategies could be implemented.
Factorization Structure of Gauge Theory Amplitudes and Application to Hard Scattering Processes at the LHC
Creators: name: Chiu, Jui-yu
name: Fuhrer, Andreas
name: Kelley, Randall
name: Manohar, Aneesh V.
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Previous work on electroweak radiative corrections to high energy scattering using soft-collinear effective theory (SCET) has been extended to include external transverse and longitudinal gauge bosons and Higgs bosons. This allows one to compute radiative corrections to all parton-level hard scattering amplitudes in the standard model to NLL order, including QCD and electroweak radiative corrections, mass effects, and Higgs exchange corrections, if the high-scale matching, which is suppressed by two orders in the log counting, and contains no large logs, is known. The factorization structure of the effective theory places strong constraints on the form of gauge theory amplitudes at high energy for massless and massive gauge theories, which are discussed in detail in the paper. The radiative corrections can be written as the sum of process-independent one-particle collinear functions, and a universal soft function. We give plots for the radiative corrections to q qbar -> W_T W_T, Z_T Z_T, W_L W_L, and Z_L H, and gg -> W_T W_T to illustrate our results. The purely electroweak corrections are large, ranging from 12% at 500 GeV to 37% at 2 TeV for transverse W pair production, and increasing rapidly with energy. The estimated theoretical uncertainty to the partonic (hard) cross-section in most cases is below one percent, smaller than uncertainties in the parton distribution functions (PDFs). We discuss the relation between SCET and other factorization methods, and derive the Magnea-Sterman equations for the Sudakov form factor using SCET, for massless and massive gauge theories, and for light and heavy external particles.
description: 44 pages, 30 figures. Refs added, typos fixed. ZL ZL plots removed because of a possible subtlety
Impact of adult weight management interventions on mental health: a systematic review and meta-analysis protocol
Creators: name: Jones, Rebecca A
name: Lawlor, Emma R
name: Griffin, Simon J
name: Van Sluijs, Esther M F
name: Ahern, Amy L
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Public health
1506
1724
public health
mental health
epidemiology

description: Introduction: The effects of interventions targeting weight loss on physical health are well described, yet the evidence for mental health is less clear. It is essential to better understand the impact of weight management interventions on mental health to optimise care and minimise risk of harm. We will assess the effect of behavioural weight management interventions on mental health in adults with overweight and obesity. Methods and analysis: The systematic review will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidance. We will include behavioural weight management interventions with a diet and/or physical activity component focusing on weight loss for adults with a body mass index ≥25 kg/m2. Randomised controlled trials (RCTs) and cluster RCTs will be the only eligible study designs. Outcomes of interest will be related to mental health. The following databases were searched from inception to 07 May 2019: MEDLINE, Embase, Cochrane database (CENTRAL), PsycINFO, ASSIA, AMED and CINAHL. The search strategy was based on four concepts: (1) adults, defined as ≥18 years, with overweight/obesity, defined as BMI ≥25kg/m², (2) weight management interventions, (3) mental health outcomes and (4) study design. The search was restricted to English-language published papers, with no other restrictions applied. Two stage screening for eligibility will be completed by two independent reviewers, with two independent reviewers completing data extraction and risk of bias assessment. Data permitting, a random-effects meta-analysis of outcomes, subgroup analyses and meta-regression will be conducted. If not appropriate, narrative synthesis and ‘levels of evidence’ assessment will be completed. Ethics and dissemination: Ethical approval is not required as primary data will not be collected. The completed systematic review will be disseminated in a peer-reviewed journal, at conferences and contribute towards the lead author’s PhD thesis. PROSPERO registration number: CRD42019131659.
A Composite Endpoint for Treatment Benefit According to Patient Preference
Creators: name: Lu, Ying
name: Zhao, Qian
name: Zou, Jiying
name: Yan, Shiyan
name: Tamaresis, John S.
name: Nelson, Lorene
name: Tu, Xin M.
name: Chen, Jie
name: Tian, Lu
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Space Science
Medicine
Pharmacology
Mathematical Sciences not elsewhere classified
Science Policy

description: Complex disorders usually affect multiple symptom domains measured by several outcomes. The importance of these outcomes is often different among patients. Current approaches integrate multiple outcomes without considering patient preferences at the individual level. In this article, we propose a new composite Desirability of Outcome Ranking (DOOR) that integrates individual level ranking of outcome importance and define a winning probability measuring the overall treatment effect. Stratified randomization can be performed based on the participants’ baseline outcome rankings. A Wilcoxon-Mann-Whitney U-statistic is used to average the pairwise DOOR between one treated and one control patient, considering the difference in these patients’ ranking of outcome importance. We use both theoretical and empirical methods to examine the statistical properties of our method and to compare with conventional approaches. We conclude that the proposed composite DOOR properly reflects patient-level preferences and can be used in pivotal trials or comparative effectiveness trials for a patient-centered evaluation of overall treatment benefits.
Acid and inflammatory sensitisation of naked mole-rat colonic afferent nerves
Creators: name: Hockley, James RF
name: Barker, Katie H
name: Taylor, Toni S
name: Callejo, Gerard
name: Husson, Zoe M
name: Bulmer, David C
name: Smith, Ewan St. J
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Research Article
Acid
bradykinin
mechanosensation
sensitisation
visceral pain

description: Acid sensing in the gastrointestinal tract is required for gut homeostasis and the detection of tissue acidosis caused by ischaemia, inflammation and infection. In the colorectum, activation of colonic afferents by low pH contributes to visceral hypersensitivity and abdominal pain in human disease including during inflammatory bowel disease. The naked mole-rat (Heterocephalus glaber) shows no pain-related behaviour to subcutaneous acid injection and cutaneous afferents are insensitive to acid, an adaptation thought to be a consequence of the subterranean, likely hypercapnic, environment in which it lives. As such we sought to investigate naked mole-rat interoception within the gastrointestinal tract and how this differed from the mouse (Mus Musculus). Here, we show the presence of calcitonin gene-related peptide expressing extrinsic nerve fibres innervating both mesenteric blood vessels and the myenteric plexi of the smooth muscle layers of the naked mole-rat colorectum. Using ex vivo colonic-nerve electrophysiological recordings, we show differential sensitivity of naked mole-rat, compared to mouse, colonic afferents to acid and the prototypic inflammatory mediator bradykinin, but not direct mechanical stimuli. In naked mole-rat, but not mouse, we observed mechanical hypersensitivity to acid, whilst both species sensitised to bradykinin. Collectively, these findings suggest that naked mole-rat colonic afferents are capable of detecting acidic stimuli; however, their intracellular coupling to downstream molecular effectors of neuronal excitability and mechanotransduction likely differs between species.
On-chip Single Nanoparticle Detection and Sizing by Mode Splitting in an Ultra-high-Q Microresonator
Creators: name: Zhu, Jiangang
name: Ozdemir, Sahin Kaya
name: Xiao, Yun-Feng
name: Li, Lin
name: He, Lina
name: Chen, Da-ren
name: Yang, Lan
Publisher: name: arXiv
Year: 2009
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The ability to detect and size individual nanoparticles with high resolution is crucial to understanding behaviours of single particles and effectively using their strong size-dependent properties to develop innovative products. We report real-time, in-situ detection and sizing of single nanoparticles, down to 30 nm in radius, using mode-splitting in a monolithic ultra-high-Q whispering-gallery-mode (WGM) microtoroid resonator. Particle binding splits a WGM into two spectrally shifted resonance modes, forming a self-referenced detection scheme. This technique provides superior noise suppression and enables extracting accurate size information in a single-shot measurement. Our method requires neither labelling of the particles nor apriori information on their presence in the medium, providing an effective platform to study nanoparticles at single particle resolution.
description: 23 pages, 8 figures
A Composite Endpoint for Treatment Benefit According to Patient Preference
Creators: name: Lu, Ying
name: Zhao, Qian
name: Zou, Jiying
name: Yan, Shiyan
name: Tamaresis, John S.
name: Nelson, Lorene
name: Tu, Xin M.
name: Chen, Jie
name: Tian, Lu
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Space Science
Medicine
Pharmacology
Mathematical Sciences not elsewhere classified
Science Policy

description: Complex disorders usually affect multiple symptom domains measured by several outcomes. The importance of these outcomes is often different among patients. Current approaches integrate multiple outcomes without considering patient preferences at the individual level. In this paper, we propose a new composite Desirability of Outcome Ranking (DOOR) that integrates individual level ranking of outcome importance and define a winning probability measuring the overall treatment effect. Stratified randomization can be performed based on the participants’ baseline outcome rankings. A Wilcoxon-Mann-Whitney U-statistic is used to average the pairwise DOOR between one treated and one control patient, considering the difference in these patients’ ranking of outcome importance. We use both theoretical and empirical methods to examine the statistical properties of our method and to compare with conventional approaches. We conclude that the proposed composite DOOR properly reflects patient-level preferences and can be used in pivotal trials or comparative effectiveness trials for a patient-centered evaluation of overall treatment benefits.
Do mobile device apps designed to support medication adherence demonstrate efficacy? A systematic review of randomised controlled trials, with meta-analysis
Creators: name: Armitage, Laura Catherine
name: Kassavou, Aikaterini
name: Sutton, Stephen
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Public health
1506
telemedicine
primary care
PUBLIC HEALTH
World Wide Web technology
GENERAL MEDICINE (see Internal Medicine)

description: Objectives: To estimate the efficacy of app-based interventions designed to support medication adherence and investigate which behaviour change techniques (BCTs) used by the apps are associated with efficacy. Design: Systematic review of randomised controlled trials (RCTs), with meta-analysis. Setting: Medline/PubMed, PsycINFO, Cumulative Index to Nursing and Allied Health Literature, Embase and Web of Science were searched from 1990 to November 2018 for RCTs conducted in any healthcare setting. Participants: Studies of participants of any age taking prescribed medication for any health condition and for any duration. Intervention: An app-based intervention delivered through a smartphone, tablet computer or personal digital assistant to help, support or advise about medication adherence. Comparator: One of (1) usual care, (2) a control app which did not use any BCTs to improve medication adherence or (3) a non-app-based comparator. Primary and secondary outcome measures: The primary outcome was the pooled effect size of changes in medication adherence. The secondary outcome was the association between BCTs used by the apps and the effect size. Results: The initial search identified 13 259 citations. After title and abstract screening, full-text articles of 83 studies were screened for eligibility. Nine RCTs with 1159 recruited participants were included. The mean age of participants was >50 years in all but one study. Health conditions of target populations included cardiovascular disease, depression, Parkinson’s disease, psoriasis and multimorbidity. The meta-analysis indicated that patients who use mobile apps to support them in taking medications are more likely to self-report adherence to medications (OR 2.120, 95% CI 1.635 to 2.747, n=988) than those in the comparator groups. Meta-regression of the BCTs did not reveal any significant associations with effect size. Conclusions: App-based medication adherence interventions may have a positive effect on patient adherence. Larger scale studies are required to further evaluate this effect, including long-term sustainability, and intervention and participant characteristics that are associated with efficacy and app usage. Prospero registration number: PROSPERO Protocol Registration Number: CRD42017080150.
Regularized relative risk regression : a non-GLM approach with emphasis on large p, small N simulations
Creators: name: You, Xinyuan (Chloe)
Publisher: name: University of British Columbia
Year: 2023

description: In clinical research, the determination of the association's strength between two events is paramount. This may involve probing the relationship between a risk factor and a health outcome, or evaluating the link between a treatment and its efficacy. The Odds Ratios (OR) and Relative Risks (RR) stand out as the predominant measures for such evaluations. While logistic regression is commonly employed for OR modeling, and Poisson regression for RR, each has its set of limitations in practical applications. In light of these limitations, Richardson et al. (2017) introduced a novel non-GLM binary regression approach for direct RR estimation using a log odds-product nuisance model. This technique elegantly sidesteps the intertwined dependence of RR on baseline risk. However, this method encountered challenges in high-dimensional and sparse model estimation (p > N). To address these issues, this study introduces a novel estimator founded on the binary regression model, which is further refined with an algorithm using Fast Iterative Shrinkage-Thresholding Algorithm (FISTA) to solve the optimization problem. This algorithm encourages sparsity in the solution and enables variable selection, thereby improving the utility for high-dimensional and sparse models. This thesis examines the properties of the estimator through simulation studies and discusses the potential for future enhancements and applications. The presented work represents a step forward in creating alternative methodologies for estimating relative risks in diverse data landscapes.
Marketing Facilities for Farm and Related Products at San Juan, Puerto Rico
Creators: name: Otten, Caleb J.
name: Serra, Guillermo
name: Morell, Bartolome M.
name: Otten, Caleb J.
name: Serra, Guillermo
name: Morell, Bartolome M.
Publisher: name: Unknown
Year: 1951
Subjects: subject: Agribusiness
subject: Crop Production/Industries
subject: Livestock Production/Industries
subject: Marketing
subject: FOS: Economics and business
subject: Production Economics

description: Excerpts from the report Summary: The primary defects in the San Juan market facilities for handling food and related products are: (1) The lack of sufficient warehouse facilities at shipside, (2) the splitting of market operations among several market areas, (3) excessive costs of cartage, deterioration, and spoilage, (4) the absence of a suitable livestock market with the necessary slaughtering and processing facilities for the proper handling of animals, particularly of heavier weights, (5) the lack of grain storage, feed mixing, and milling facilities for the efficient handling of imported grain and utilization of the various commodities produced on the Island that could be used in mixed feeds, and (6) the need for improved vegetable-oil-extracting facilities. To correct these defects this report proposes the construction of three types of facilities, which will provide a satisfactory outlet for an increased production of food products on the Island and for the efficient handling, processing, and distribution of these and imported products to the people in the San Juan metropolitan area, and to a lesser degree throughout the Island.