cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Adiponectin GWAS loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences
Creators: name: Raulerson, C.K.
name: Brotman, S.M.
name: Collins, F.S.
name: Narisu, N.
name: Iyengar, A.K.
name: Crain, A.T.
name: Spracklen, C.N.
name: Davis, J.P.
name: Currin, K.W.
name: Li, Y.
name: Vadlamudi, S.
name: Perrin, H.J.
name: Scott, L.J.
name: Boehnke, M.
name: Locke, A.E.
name: Jackson, A.U.
name: Wu, Y.
name: Laakso, M.
name: Mohlke, K.L.
name: Stringham, H.M.
name: Kuusisto, J.K.
name: Cannon, M.E.
name: Welch, R.P.
name: Fuchsberger, C.
name: Pajukanta, P.
Publisher: name: Public Library of Science
Year: 2020

description: Loci identified in genome-wide association studies (GWAS) can include multiple distinct association signals. We sought to identify the molecular basis of multiple association signals for adiponectin, a hormone involved in glucose regulation secreted almost exclusively from adipose tissue, identified in the Metabolic Syndrome in Men (METSIM) study. With GWAS data for 9,262 men, four loci were significantly associated with adiponectin: ADIPOQ, CDH13, IRS1, and PBRM1. We performed stepwise conditional analyses to identify distinct association signals, a subset of which are also nearly independent (lead variant pairwise r2<0.01). Two loci exhibited allelic heterogeneity, ADIPOQ and CDH13. Of seven association signals at the ADIPOQ locus, two signals colocalized with adipose tissue expression quantitative trait loci (eQTLs) for three transcripts: trait-increasing alleles at one signal were associated with increased ADIPOQ and LINC02043, while trait-increasing alleles at the other signal were associated with decreased ADIPOQ-AS1. In reporter assays, adiponectin-increasing alleles at two signals showed corresponding directions of effect on transcriptional activity. Putative mechanisms for the seven ADIPOQ signals include a missense variant (ADIPOQ G90S), a splice variant, a promoter variant, and four enhancer variants. Of two association signals at the CDH13 locus, the first signal consisted of promoter variants, including the lead adipose tissue eQTL variant for CDH13, while a second signal included a distal intron 1 enhancer variant that showed ~2-fold allelic differences in transcriptional reporter activity. Fine-mapping and experimental validation demonstrated that multiple, distinct association signals at these loci can influence multiple transcripts through multiple molecular mechanisms.
Long-range correction for tight-binding TD-DFT
Creators: name: Humeniuk, Alexander
name: Mitric, Roland
Publisher: name: arXiv
Year: 2015
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: We present two improvements to the tight-binding approximation of time-dependent density functional theory (TD-DFTB): Firstly, we add an exact Hartree-Fock exchange term, which is switched on at large distances, to the ground state Hamiltonian and similarly to the coupling matrix that enters the linear response equations for the calculation excited electronic states. We show that the excitation energies of charge transfer states are improved relative to the standard approach without the long-range correction by testing the method on a set of molecules from the database in J. Chem. Phys. (2008),128,044118. that are known to exhibit problematic charge transfer states. The degree of spatial overlap between occupied and virtual orbitals indicates where TD-DFTB and lc-TD-DFTB can be expected to produce large errors. Secondly, we improve the calculation of oscillator strengths. The transition dipoles are obtained from Slater Koster files for the dipole matrix elements between valence orbitals. In particular excitations localized on a single atom, which appear dark when using Mulliken transition charges, in this way acquire a more realistic oscillator strength. These extensions pave the way for using long-range corrected TD-DFTB (lc-TD-DFTB) to describe the electronic structure of large chromophoric polymers, where uncorrected TD-DFTB fails to describe the high degree of conjugation and produces spurious low-lying charge transfer states.
description: Keywords: DFT, TD-DFT, DFTB, TD-DFTB, tight-binding DFT, long-range correction, charge transfer
20 years of the ICRC Code of Conduct for Disaster Relief: What do we need to improve?
Creators: name: Pospieszna, Paulina
Publisher: name: figshare
Year: 2020
Subjects: subject: 160607 International Relations
subject: FOS: Political science

description: The Code of Conduct for Disaster Relief of the International Committee of the Red Cross (ICRC) was written for use by the International Red Cross, Red Crescent Movements, and non-governmental organisations (NGOs) working in disaster relief. The code was published just after the Rwanda genocide in April, 1994.1 The code consists of a purpose and four definitions; it outlines ten general principles of conduct, and includes three annexes of recommendations to governments of disaster-affected countries, donor governments, and intergovernmental organisations.
Supplemental Analysis of Preprint Service Questions from Credibility of preprints: an interdisciplinary survey of researchers
Creators: name: Soderberg, Courtney K.
name: Errington, Timothy M.
name: Nosek, Brian A.
Publisher: name: The Royal Society
Year: 2020
Subjects: subject: 179999 Psychology and Cognitive Sciences not elsewhere classified
subject: FOS: Psychology

description: A description and analysis of survey questions related to the credibility of preprint services.
Report on means to boost consumer trust and acceptability towards alternative proteins
Creators: name: Jónsdóttir, Rósa
name: Paasi, Jaakko
name: Boulton, Andy
name: Tillotson, Melissa
name: Matullat, Imke
name: Lee-Gammage, Sam
name: Sveinsdottir, Kolbrun
name: Diebel, Franziska
Publisher: name: Zenodo
Year: 2023

description: This is deliverable 5.4 in the Horizon 2020 funded project NextGenProteins. One of the objectives of NextGenProteins project and its WP5 ‘Market opportunities and business potential’ was to identify suitable approaches to boost consumer trust and acceptability towards alternative protein sources and processes. Special attention was paid to the three alternative protein concepts under consideration in the NextGenProteins project for food applications. This report is the summary of work done on the subject.
Supplementary information from Dynamical Ising model of spatially coupled ecological oscillators
Creators: name: Nareddy, Vahini Reddy
name: Machta, Jonathan
name: Abbott, Karen C.
name: Shadisadat Esmaeili
name: Hastings, Alan
Publisher: name: The Royal Society
Year: 2020
Subjects: subject: Biophysics
subject: 60114 Systems Biology
subject: FOS: Biological sciences
subject: 60199 Biochemistry and Cell Biology not elsewhere classified
subject: 69999 Biological Sciences not elsewhere classified

description: Details of the models and methods used in the research
Strategi Tingkatkan Sitasi dan Google Scholar
Creators: name: Harls Evan Riant Siahaan
Publisher: name: Zenodo
Year: 2020

description: Webinar RJI Jateng Seri 13 Journal Publishing Management diadakan oleh Relawan Jurnal Indonesia Pengurus Daerah Jawa Tengah pada Hari Sabtu Tanggal 17 Oktober 2020 Pukul 09.00-11.30 WIB. Materi Strategi Tingkatkan Sitasi dan Google Scholar dibawakan sendiri oleh Harls Evan Riant Siahaan (Sekolah Tinggi Teologi Pelita Bangsa).
Multi-SNP mediation intersection-union test
Creators: name: Zhong, W.
name: Zheng, X.
name: Spracklen, C.N.
name: Mohlke, K.L.
name: Fine, J.
name: Li, Y.
Publisher: name: Oxford University Press
Year: 2019

description: Tens of thousands of reproducibly identified GWAS (Genome-Wide Association Studies) variants, with the vast majority falling in non-coding regions resulting in no eventual protein products, call urgently for mechanistic interpretations. Although numerous methods exist, there are few, if any methods, for simultaneously testing the mediation effects of multiple correlated SNPs via some mediator (e.g. the expression of a gene in the neighborhood) on phenotypic outcome. We propose multi-SNP mediation intersection-union test (SMUT) to fill in this methodological gap. Our extensive simulations demonstrate the validity of SMUT as well as substantial, up to 92%, power gains over alternative methods. In addition, SMUT confirmed known mediators in a real dataset of Finns for plasma adiponectin level, which were missed by many alternative methods. We believe SMUT will become a useful tool to generate mechanistic hypotheses underlying GWAS variants, facilitating functional follow-up.
On the Cosmic Evolution of Fe/Mg in QSO Absorption Line Systems
Creators: name: Dey, Arjun
name: Torrey, Paul
name: Rubin, Kate H. R.
name: Zhu, Guangtun Ben
name: Suresh, Joshua
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We investigate the variation of the ratio of the equivalent widths of the FeII$λ$2600 line to the MgII$λλ$2796,2803 doublet as a function of redshift in a large sample of absorption lines drawn from the JHU-SDSS Absorption Line Catalog. We find that despite large scatter, the observed ratio shows a trend where the equivalent width ratio $\mathcal{R}\equiv W_{\rm FeII}/W_{\rm MgII}$ decreases monotonically with increasing redshift $z$ over the range $0.55 \le z \le 1.90$. Selecting the subset of absorbers where the signal-to-noise ratio of the MgII equivalent width $W_{\rm MgII}$ is $\ge$3 and modeling the equivalent width ratio distribution as a gaussian, we find that the mean of the gaussian distribution varies as $\mathcal{R}\propto (-0.045\pm0.005)z$. We discuss various possible reasons for the trend. A monotonic trend in the Fe/Mg abundance ratio is predicted by a simple model where the abundances of Mg and Fe in the absorbing clouds are assumed to be the result of supernova ejecta and where the cosmic evolution in the SNIa and core-collapse supernova rates is related to the cosmic star-formation rate. If the trend in $\mathcal{R}$ reflects the evolution in the abundances, then it is consistent with the predictions of the simple model.
description: 10 pages, 4 figures, final version published in MNRAS
Colocalization of GWAS and eQTL signals at loci with multiple signals identifies additional candidate genes for body fat distribution
Creators: name: Boehnke, M.
name: Wu, Y.
name: Collins, F.S.
name: Ko, A.
name: He, A.
name: Tilford, C.
name: Raulerson, C.K.
name: Stringham, H.M.
name: Fuchsberger, C.
name: Mohlke, K.L.
name: Civelek, M.
name: Narisu, N.
name: Jackson, A.U.
name: Pan, C.
name: Scott, L.J.
name: Locke, A.E.
name: Broadaway, K.A.
name: Kuusisto, J.
name: Pajukanta, P.
name: Laakso, M.
name: Lusis, A.J.
Publisher: name: Oxford University Press
Year: 2019

description: Integration of genome-wide association study (GWAS) signals with expression quantitative trait loci (eQTL) studies enables identification of candidate genes. However, evaluating whether nearby signals may share causal variants, termed colocalization, is affected by the presence of allelic heterogeneity, different variants at the same locus impacting the same phenotype. We previously identified eQTL in subcutaneous adipose tissue from 770 participants in the Metabolic Syndrome in Men (METSIM) study and detected 15 eQTL signals that colocalized with GWAS signals for waist-hip ratio adjusted for body mass index (WHRadjBMI) from the Genetic Investigation of Anthropometric Traits consortium. Here, we reevaluated evidence of colocalization using two approaches, conditional analysis and the Bayesian test COLOC, and show that providing COLOC with approximate conditional summary statistics at multi-signal GWAS loci can reconcile disagreements in colocalization classification between the two tests. Next, we performed conditional analysis on the METSIM subcutaneous adipose tissue data to identify conditionally distinct or secondary eQTL signals. We used the two approaches to test for colocalization with WHRadjBMI GWAS signals and evaluated the differences in colocalization classification between the two tests. Through these analyses, we identified four GWAS signals colocalized with secondary eQTL signals for FAM13A, SSR3, GRB14 and FMO1. Thus, at loci with multiple eQTL and/or GWAS signals, analyzing each signal independently enabled additional candidate genes to be identified.
title: Genetic analyses on male-pattern hair loss
title: Exploring links with rare variants, COVID-19 and short anagen hair syndrome
titleType: AlternativeTitle
Creators: name: Henne, Sabrina Katrin
Publisher: name: Universitäts- und Landesbibliothek Bonn
Year: 2024
Subjects: subject: ddc:570
subject: ddc:610

description: Male pattern hair loss (MPHL) is a highly heritable condition and the most common form of hair loss in men. The phenotype is characterized by progressive hair loss in the frontotemporal and vertex areas of the scalp. Molecular genetic studies into common variants have provided substantial insights into the genetic basis of MPHL, identifying 389 risk loci and implicating numerous candidate genes and pathways. However, the underlying pathobiology of the hair loss remains incompletely understood and the identified risk loci explain only a portion of MPHL's estimated heritability, suggesting the existence of as yet unidentified genetic risk factors. On an epidemiological level, MPHL has been linked to other traits and conditions, such as cardiovascular disease and prostate cancer, and has recently emerged as a putative risk factor for severe COVID-19. In addition to epidemiologic data, the availability of large-scale genetic datasets enables a systematic investigation of pleiotropic effects between traits at individual loci and on a genome-wide level. This resulted in the identification of shared genetic factors between MPHL and e.g., Parkinson’s disease and early puberty, respectively. Leveraging data from the UK Biobank, this thesis aimed (i) to identify additional genetic risk factors through the investigation of the contribution of rare variants to MPHL, and (ii) to dissect potential associations of MPHL with COVID-19 and monogenic hair disorders on an epidemiological and/or genetic level. The investigation of rare variants involved single-variant and gene-based association analyses of exome sequencing data, marking the first systematic analysis in this context. The findings provide evidence for the involvement of rare variants in five genes in MPHL etiology, including previously implicated genes (WNT10A, EDA2R) and novel candidate genes at known risk loci (HEPH) and beyond (CEPT1, EIF3F), as well as revealing an enrichment of genes causal for genotrichoses. Regarding the potential association between MPHL and severe COVID-19, no epidemiological or genome-wide genetic correlation was identified, contrasting previous studies. The assessment of potential genetic overlap between MPHL and short anagen hair syndrome (SAH) identified c.682T>A and c.321C>A in WNT10A as shared genetic determinants for both traits. In summary, this thesis provides insights into MPHL genetics, contributing to ongoing gene identification efforts and highlighting a shared genetic basis with other hair- and skin-related conditions. These findings underscore the relevance of MPHL research in a broader dermatological context.
Consumer views about the Next Generation proteins for food in Europe
Creators: name: Arvola, Anne
name: Kulju, Minna
name: Pennanen, Kyosti
name: Matullat, Imke
name: Sveinsdottir, Kolbrun
name: Briem, Helgi
name: Paasi, Jaakko
Publisher: name: Zenodo
Year: 2021

description: This is Deliverable 5.1 for the Horizon Europe funded project NextGenProteins. This study aimed to gain a European view on consumer attitudes towards the three NextGen proteins, their production processes, and the use of resulting protein ingredients in food products. The results of the study are based on online focus group discussions with selected consumers from Finland, Germany, Iceland and Italy, and an online survey implemented in Finland, Germany, Iceland, Italy, Poland, Sweden, and UK with 6600 respondents in total.
Well-being convergence in the European Union
Creators: name: Decancq, Koen
name: Gamage, Sakura P.
Publisher: name: Zenodo
Year: 2023
Subjects: convergence
decomposition
equivalent income
well-being
preferences
life satisfaction

description: In this study, a method is proposed to measure well-being inequality and to test for well-being convergence in the EU. The method considers well-being as a multidimensional concept and recognizes that individuals may have different preferences about the relative importance of the different dimensions of well-being. The focus is on interpersonal well-being convergence (i.e., a reduction in well-being inequality between all European citizens) and on intercountry well-being convergence (i.e., a reduction in the well-being inequality between the European countries). To illustrate the method, we use data from EU-SILC (2005-2019) about five dimensions of well-being: income, employment, crime, pollution and health. The relative importance of these dimensions is estimated with a life satisfaction regression. Results show interpersonal and intercountry well-being convergence over the study period, but increased well-being inequality during the Great Recession (2008-2015). Several decompositions are used to shed light on the drivers of well-being convergence in Europe.
Enhancer deletion and allelic effects define a regulatory molecular mechanism at the VLDLR cholesterol GWAS locus
Creators: name: Mohlke, K.L.
name: Zeynalzadeh, M.
name: Vadlamudi, S.
name: Iyengar, A.K.
name: Davis, J.P.
name: Roman, T.S.
Publisher: name: Oxford University Press
Year: 2019

description: Total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) are heritable risk factors for cardiovascular disease, yet the molecular mechanisms underlying the majority of blood lipid-associated genome-wide association studies signals remain elusive. One association signal is located in intron 3 of VLDLR; rs3780181-A is a risk allele associated (P ≤ 2 × 10-9) with increased TC and LDL-C.We investigated variants, genes and mechanisms underlying this association signal.We used a functional genetic approach to show that the intronic region spanning rs3780181 exhibited 1.6-7.6-fold enhancer activity in human HepG2 hepatocyte, THP-1 monocyte and Simpson-Golabi-Behmel Syndrome (SGBS) preadipocyte cells and that the rs3780181-A risk allele showed significantly less enhancer activity compared with the G allele, consistent with the direction of an expression quantitative trait locus in liver. In addition, rs3780181 alleles showed differential binding to multiple nuclear proteins, including stronger IRF2 binding to the rs3780181 G allele.We used a CRISPR-cas9 approach to delete 475 and 663 bp of the putative enhancer element in HEK293T kidney cells; compared to expression of mock-edited cell lines, the homozygous enhancer deletion cell lines showed 1.2-fold significantly (P < 0.04) decreased expression of VLDLR, as well as 1.5-fold decreased expression of SMARCA2, located 388 kb away. Together, these results identify an enhancer of VLDLR expression and suggest that altered binding of one or more factors bound to rs3780181 alleles decreases enhancer activity and reduces at least VLDLR expression, leading to increased TC and LDL-C.
Planar radiation zeros in five-parton QCD amplitudes
Creators: name: Harland-Lang, L. A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We demonstrate the existence of `planar', or `type-II', radiation zeros in 5-parton QCD scattering processes. That is, the Born amplitudes are shown to completely vanish for particular kinematic configurations, when all the particle 3-momenta lie in a plane. This result is shown to follow particularly simply from the known BCJ relations between the colour-ordered tree amplitudes, and the MHV formalism is used to express the additional kinematic constraint as a relatively simple expression in terms of only rapidity differences between the final-state partons. In addition, we find that zeros exist for non-planar configurations of the final-state partons, but for which the normal `type-I' conditions on the particle four-momenta do not generally apply. We present numerical results and comment on the possibility of observing planar radiation zeros in hadronic collisions, via central exclusive three-jet production.
description: 22 pages, 5 figures. Version accepted for publication in JHEP
Sensitivity to Triple Higgs Couplings via Di-Higgs Production in the 2HDM at the (HL-)LHC
Creators: name: Arco, F.
name: Heinemeyer, S.
name: Mühlleitner, M.
name: Radchenko Serdula, Kateryna
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2022
Subjects: coupling, Higgs
gluon, fusion
potential, Higgs
dimension, 2
CERN LHC Coll, upgrade
Higgs particle
sensitivity
new physics
GeV
benchmark
suppression
TeV

description: An important task of the LHC is the investigation of the Higgs-boson sector. Of particular interest is the reconstruction of the Higgs potential, i.e. the measurement of the Higgs self-couplings. Based on previous analyses, within the 2HDMs type~I and~II, we analyze several two-dimensional benchmark planes that are over large parts in agreement with all theoretical and experimental constraints. For these planes we evaluate di-Higgs production cross sections at the (HL-)LHC with a center-of-mass energy of 13 TeV at NLO in the heavy top-quark limit with the code HPAIR. We investige in particular the process $gg \to hh$, with $h$ being the Higgs boson discovered at the LHC with a mass of about 125 GeV. The top box diagram of the loop-mediated gluon fusion process into Higgs pairs interferes with the $s$-channel exchange of the two CP-even 2HDM Higgs bosons $h$ and $H$ involving the trilinear couplings $\lambda_{hhh}$ and $\lambda_{hhH}$, respectively. Depending on the size of the involved top-Yukawa and triple Higgs couplings as well as on the mass of $H$, the contribution of the $s$-channel $H$~diagram can be dominating or be highly suppressed. We find regions of the allowed parameter space in which the di-Higgs production cross section can differ by many standard deviations from its SM prediction, indicating possible access to deviations in $\lambda_{hhh}$ from the SM value $\lambda_{\rm SM}$ and/or contributions involving $\lambda_{hhH}$. The sensitivity to $\lambda_{hhH}$ is further analyzed employing the $m_{hh}$ distributions. We demonstrate how a possible measurement of $\lambda_{hhH}$ depends on the various experimenal uncertainties. Depending on the underlying parameter space, the HL-LHC may have the option not only to detect beyond-the-Standard-Model triple Higgs couplings, but also to provide a first rough measurement of their sizes.
Deciphering the Emerging Complexities of Molecular Mechanisms at GWAS Loci
Creators: name: Mohlke, K.L.
name: Cannon, M.E.
Publisher: name: Cell Press
Year: 2018

description: Genome-wide association studies (GWASs) have identified thousands of loci associated with hundreds of complex diseases and traits, and progress is being made toward elucidating the causal variants and genes underlying these associations. Functional characterization of mechanisms at GWAS loci is a multi-faceted challenge. Challenges include linkage disequilibrium and allelic heterogeneity at each locus, the noncoding nature of most loci, and the time and cost needed for experimentally evaluating the potential mechanistic contributions of genes and variants. As GWAS sample sizes increase, more loci are identified, and the complexities of individual loci emerge. Loci can consist of multiple association signals, each of which can reflect the influence of multiple variants, inseparable by association analyses. Each signal within a locus can influence the same or different target genes. Experimental studies of genes and variants can differ on the basis of cell type, cellular environment, or other context-specific variables. In this review, we describe the complexity of mechanisms at GWAS loci—including multiple signals, multiple variants, and/or multiple genes—and the implications these complexities hold for experimental study design and interpretation of GWAS mechanisms.
Global fits of the two-loop renormalized Two-Higgs-Doublet model with soft $Z_2$ breaking
Creators: name: Chowdhury, Debtosh
name: Eberhardt, Otto
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We determine the next-to-leading order renormalization group equations for the Two-Higgs-Doublet model with a softly broken $Z_2$ symmetry and CP conservation in the scalar potential. We use them to identify the parameter regions which are stable up to the Planck scale and find that in this case the quartic couplings of the Higgs potential cannot be larger than 1 in magnitude and that the absolute values of the S-matrix eigenvalues cannot exceed 2.5 at the electroweak symmetry breaking scale. Interpreting the 125 GeV resonance as the light CP-even Higgs eigenstate, we combine stability constraints, electroweak precision and flavour observables with the latest ATLAS and CMS data on Higgs signal strengths and heavy Higgs searches in global parameter fits to all four types of $Z_2$ symmetry. We quantify the maximal deviations from the alignment limit and find that in type II and Y the mass of the heavy CP-even (CP-odd) scalar cannot be smaller than 340 GeV (360 GeV). Also, we pinpoint the physical parameter regions compatible with a stable scalar potential up to the Planck scale. Motivated by the question how natural a Higgs mass of 125 GeV can be in the context of a Two-Higgs-Doublet model, we also address the hierarchy problem and find that the Two-Higgs-Doublet model does not offer a perturbative solution to it beyond 5 TeV.
description: 30 pages, 29 figures. Major update of the experimental inputs; references added
Mixed matrix composite PEM with super proton conductivity developed from ionic liquid modified silica nanoparticle and polybenzimidazole
Creators: name: Gorre, Akhil
name: Das, Anupam
name: Jana, Tushar
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Phosphoric acid (PA) leaching, low proton conductivity and weak mechanical strength of the polybenzimidazole (PBI) membrane need to be improved considerably for the development of proton exchange membrane (PEM). We have addressed these issues by preparing a mixed matrix composite (MMC) membrane comprising of oxy-polybenzimidazole (OPBI) and imidazole ionic liquid modified silica (ImILSi). Imidazolium based ionic liquid was synthesized and grafted to the surface of the silica nanoparticles (SiNP) to obtain ImILSi which further blended with OPBI to obtain OPBI@ImILSi. The uniform dispersion nature of the ImILSi in the OPBI matrix and the strong H-bonded interfacial interactions between nanofillers and polymers are found to be primary reason for significant improvement of various physical properties of the MMC. TGA, DMA and stress-strain studies exhibited significant enhancement in the thermal and mechanical properties of the MMC membranes. Most importantly, due to the loading of hydrophilic ImILSi, the MMC membranes resulted higher PA loading (∼3-fold increase) which enabled the formation of facial proton transport nanochannels for their superior proton conduction under anhydrous environment and elevated temperature. For example, the OPBI@ImILSi-3% membrane showed proton conductivity value of 0.219 S cm−1 at 160 °C which is a ∼4-fold increase compared to OPBI membrane.
Tripp Bajada Canal Preliminary Field Notes
Creators: name: Lancaster, Don
Publisher: name: Synergetics Press
Year: 2022
Subjects: subject: safford arizona
valueUri: https://core.tdar.org/browse/temporal-keyword/8335/safford-arizona
subject: Mogollon
valueUri: https://core.tdar.org/browse/culture-keyword/34/mogollon
subject: Hohokam
valueUri: https://core.tdar.org/browse/culture-keyword/21/hohokam
subject: Resource Extraction / Production / Transportation Structure or Features
valueUri: https://core.tdar.org/browse/site-type/272/resource-extraction-production-transportation-structure-or-features
subject: Non-Domestic Structures
valueUri: https://core.tdar.org/browse/site-type/309/non-domestic-structures
subject: Domestic Structure or Architectural Complex
valueUri: https://core.tdar.org/browse/site-type/251/domestic-structure-or-architectural-complex
subject: bajada hanging canal Mount Graham
valueUri: https://core.tdar.org/browse/other-keyword/167431/bajada-hanging-canal-mount-graham
subject: Environment Research
valueUri: https://core.tdar.org/browse/investigation-type/13/environment-research
subject: Architectural Documentation
valueUri: https://core.tdar.org/browse/investigation-type/16/architectural-documentation
subject: Archaeological Overview
valueUri: https://core.tdar.org/browse/investigation-type/1/archaeological-overview
subject: Collections Research
valueUri: https://core.tdar.org/browse/investigation-type/3/collections-research
subject: Reconnaissance / Survey
valueUri: https://core.tdar.org/browse/investigation-type/7/reconnaissance-survey

description: Preliminary field notes for the Trip Bajada Canal, the westernmost of many dozens of newly distovered Safford area prehistoric canals. Includes links to other field notes and key papers.
АНАЛИЗ ПУБЛИКАЦИОННОЙ АКТИВНОСТИ ПО ИЗУЧЕНИЮ АКУСТИЧЕСКОГО ЗАГРЯЗНЕНИЯ ПО ВЛИЯНИЮ НА ОКРУЖАЮЩУЮ ПРИРОДНУЮ СРЕДУ И ЗДОРОВЬЕ ЧЕЛОВЕКА
Creators: name: Т. Р. Гарифьянов
name: Н. Г. Курамшина
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: шумовое воздействие
акустическое загрязение
публикационная активность
окружающая среда
здоровье человека.

description: Проведен анализ публикационной активности по акустическому загрязнению за рубежом, показаны тенденции и хронология ее развития. Проанализированы информационные и графические материалы, обоснована актуальность темы, показан анализ цитирования публикаций в различных областях науки. Результаты исследования могут быть использованы специалистами в области защиты от акустического воздействия. Проведенный статистический анализ показателей баз данных в целом показал растущий интерес к изучению акустического загрязнения.
ВЗАИМОСВЯЗЬ МЕХАНИЧЕСКОГО И АГРЕГАТНОГО СОСТАВА ПОЧВЫ С ЕЕ МИКРОБИОЛОГИЧЕСКОЙ АКТИВНОСТЬЮ
Creators: name: В. А. Лыхман
name: М. Н. Дубинина
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: почвенная микрофлора
коллоиды почвы
аэробные и анаэробные микроорганизмы
аэрация почвы
дисперсность почвы
почвенная структура.

description: Количество и качество почвенных структурных фракций находится во взаимосвязи с почвенной микрофлорой. Работами Худякова доказано, что бактерии в почве поглощаются наиболее мелкими ее частями и это поглощение находится в прямой зависимости от содержания иловатых и пылеватых частиц диаметром до 0,01 мм. Путем диспергирования почвенных коллоидов можно вызвать усиление активности поглощенных бактерий и ускорить минерализацию органических соединений, находящихся в почве. Доказано, чем крупнее частица, тем больше она содержит воздушных полостей, тем больше влаги она способна задержать, тем большей обсемененностью она обладает, тем ценнее данная фракция в агрономическом отношении. Низкая активность микрофлоры мелких частиц объясняется большей однородностью химического состава, большей плотностью и низкой аэрацией.
title: Before COVID-19 : the effect of the 1918 pandemic on Scotland's children
Creators: name: Connelly, Graham
name: Lawrence, Michael
Publisher: name: Strathprints - University of Strathclyde
Year: 2020

description: The erroneously named 'Spanish Flu' pandemic of 1918-1920 was responsible for the deaths of at least 50 million people worldwide. Its point of arrival in the UK was Glasgow, Scotland, probably brought by troops returning from the battlefields of the Great War. The first infections were in factories and a boys' industrial school and the first recorded deaths were of eight children at the former Smyllum Orphanage in Lanark. The British Newspaper Archive is a valuable online source of reports about the pandemic from local Scottish newspapers of the time, but there is more research to be done in the National Records of Scotland and in local archives. The authors welcome advice on potential sources of the effects of the 1918 pandemic on Scottish orphanages, children's homes and industrial schools.
2020_IJFGCN_Life Share-A localized Blood Donor Connector Using chatbots.pdf
Creators: name: U P, Narendra
Publisher: name: figshare
Year: 2022
Subjects: subject: 109999 Technology not elsewhere classified
subject: FOS: Other engineering and technologies

description: The web application will periodically update the details pertaining to donors and  recipients promptly. And the administrators access all web application information, with an  interactive chat bot in order to process queries and provides quick response that will speed up the  process. Also, the proposed work includes Push technology that will alert users for blood requirement  via message, which is bound to a specific location during emergencies. This web-based framework is  easy to scale, effective and adaptable to the growing need for blood non-availability. This technique  of optimization can save life’s at risk.
A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression
Creators: name: Huyghe, J.R.
name: Welch, R.P.
name: Albanus, R.D.
name: Lawlor, N.
name: Stitzel, M.L.
name: Kursawe, R.
name: Vadlamudi, S.
name: Mathur, A.
name: Kuusisto, J.
name: Ucar, D.
name: Boehnke, M.
name: Parker, S.C.J.
name: Laakso, M.
name: Wolford, B.N.
name: Mohlke, K.L.
name: Fuchsberger, C.
name: Bolisetty, M.
name: Uyar, A.
name: Kycia, I.
name: Khetan, S.
Publisher: name: Cell Press
Year: 2018

description: Genome-wide association studies (GWASs) and functional genomics approaches implicate enhancer disruption in islet dysfunction and type 2 diabetes (T2D) risk. We applied genetic fine-mapping and functional (epi)genomic approaches to a T2D- and proinsulin-associated 15q22.2 locus to identify a most likely causal variant, determine its direction of effect, and elucidate plausible target genes. Fine-mapping and conditional analyses of proinsulin levels of 8,635 non-diabetic individuals from the METSIM study support a single association signal represented by a cluster of 16 strongly associated (p < 10−17) variants in high linkage disequilibrium (r2 > 0.8) with the GWAS index SNP rs7172432. These variants reside in an evolutionarily and functionally conserved islet and β cell stretch or super enhancer; the most strongly associated variant (rs7163757, p = 3 × 10−19) overlaps a conserved islet open chromatin site. DNA sequence containing the rs7163757 risk allele displayed 2-fold higher enhancer activity than the non-risk allele in reporter assays (p < 0.01) and was differentially bound by β cell nuclear extract proteins. Transcription factor NFAT specifically potentiated risk-allele enhancer activity and altered patterns of nuclear protein binding to the risk allele in vitro, suggesting that it could be a factor mediating risk-allele effects. Finally, the rs7163757 proinsulin-raising and T2D risk allele (C) was associated with increased expression of C2CD4B, and possibly C2CD4A, both of which were induced by inflammatory cytokines, in human islets. Together, these data suggest that rs7163757 contributes to genetic risk of islet dysfunction and T2D by increasing NFAT-mediated islet enhancer activity and modulating C2CD4B, and possibly C2CD4A, expression in (patho)physiologic states.
ПРОБЛЕМА ВЛИЯНИЯ ПОЧВЕННОЙ АЭРАЦИИ НА ЖИЗНЕДЕЯТЕЛЬНОСТЬ РАЗЛИЧНЫХ ГРУПП МИКРООРГАНИЗМОВ В ТРУДАХ ОТЕЧЕСТВЕННЫХ И ЗАРУБЕЖНЫХ УЧЕНЫХ
Creators: name: В. А. Лыхман
name: М. Н. Дубинина
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: почвенная микрофлора
сапрофиты
актиномицеты
аэрация почвы
почвенная структура.

description: Изучению и управлению такими физико-химическими процессами, как перераспределение органического вещества почвы, формирование и деградация структуры, газообмен в почвенной среде, посвящены многочисленные труды отечественных и зарубежных ученых. Доказано, что повышенное уплотнение почвенных слоев приводит к снижению поступления кислорода и замедлению окислительных процессов, поэтому регулирование жизнедеятельности аэробных микроорганизмов возможно за счет механической обработки почвы, рыхления и дренажа. Развитие анаэробных микроорганизмов, происходящее в верхних слоях почвы, регламентируется наличием в почвенных комочках углекислого газа. Как следует из экспериментов Мишустина, Муромцева и других исследователей, микроорганизмы, населяющие почвенные частицы, регулируют преобразования почвенного органического вещества и обладают способностью сдерживать рост неспецифических почвенных микроорганизмов, попадающих из воздуха.
Using models to model-check recursive schemes
Creators: name: Salvati, Sylvain
name: Walukiewicz, Igor
Publisher: name: arXiv
Year: 2015
Subjects: subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences

description: We propose a model-based approach to the model checking problem for recursive schemes. Since simply typed lambda calculus with the fixpoint operator, lambda-Y-calculus, is equivalent to schemes, we propose the use of a model of lambda-Y-calculus to discriminate the terms that satisfy a given property. If a model is finite in every type, this gives a decision procedure. We provide a construction of such a model for every property expressed by automata with trivial acceptance conditions and divergence testing. Such properties pose already interesting challenges for model construction. Moreover, we argue that having models capturing some class of properties has several other virtues in addition to providing decidability of the model-checking problem. As an illustration, we show a very simple construction transforming a scheme to a scheme reflecting a property captured by a given model.
description: Long version of a paper presented at TLCA 2013
title: Effectiveness and Heterogeneous Effects of Purchase Grants for Electric Vehicles
Creators: name: Haan, Peter
name: Santonja, Adrián
name: Zaklan, Aleksandar
Publisher: name: Hertie School
Year: 2023

description: We evaluate German purchase subsidies for battery electric vehicles (BEVs) and plug-in hybrid electric vehicles (PHEVs) using data on new vehicle registrations in Germany during 2015-2022. We account for confounding time trends and interacting EU-level CO2 standards using neighboring countries as a control group. The program was cost-ineffective, as only 40% of BEV and 25% of PHEV registrations were subsidy-induced, and had strong distributional effects, with greater uptake in wealthier and greener counties. The implied abatement cost of 870 euro per ton of CO2 for BEVs and 2,470 euro for PHEVs suggests that subsidies to PHEVs were especially cost-ineffective.
ВЛИЯНИЕ РАЗЛИЧНЫХ СИСТЕМ ЗАЩИТЫ РАСТЕНИЙ НА ФЕРМЕНТАТИВНУЮ АКТИВНОСТЬ ЧЕРНОЗЕМА
Creators: name: О. И. Наими
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: чернозем обыкновенный
средства защиты растений
каталаза
инвертаза
фосфатаза.

description: Изучали влияние химических и биологических средств защиты растений на ферментативную активность чернозема обыкновенного под посевами нута. Установлено, что при обработке средствами химической защиты растений активность каталазы и инвертазы и снижается, а активность фосфатазы – увеличивается. Обработка средствами биологической защиты растений стимулирует активность каталазы и ингибирует активность инвертазы. При этом активность фосфатазы сохраняется на одном уровне.
СПЕЦИФИКА РАЗВИТИЯ СОВЕТСКОЙ ЭСТРАДНОЙ ПЕСНИ ВТОРОЙ ПОЛОВИНЫ 1980-х–1991
Creators: name: С. В. Николаев
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: музыка
эстрада
культура
песня
искусство
советская песенная культура
отечественная массовая музыкальная культура.

description: Статья посвящена особенностям развития советской эстрадной музыки во второй половине 1980-х – 1991 гг. В работе рассмотрены особенности ведущих музыкальных жанров отечественной эстрадной песни. Раскрываются культурноисторические мотивы развития эстрадной музыки. Определяется социокультурное значение и особенность работы отдельных эстрадных деятелей. Определяются предпосылки для дальнейшего развития эстрадной музыки в деятельности шоу-бизнеса. В обособившемся порядке говорится об особенности эволюционирования песенной культуры.
ПАТРИОТИЗМ И ФОРМЫ ЕГО ПРОЯВЛЕНИЯ У ШКОЛЬНИКОВ ГОРОДА КУЙБЫШЕВ В ПЕРИОД ВЕЛИКОЙ ОТЕЧЕСТВЕННОЙ ВОЙНЫ
Creators: name: Д. А. Афанасьева
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: Великая Отечественная война
Куйбышев
тыловые процессы
педагогика
патриотизм.

description: Статья посвящена исследованию патриотических настроений у школьников тылового города Куйбышева в период Великой Отечественной войны. Изучена система помощи детям в условиях войны, реализуемая через систему школ и пионерских организаций, а также способы формирования ими у школьников патриотических настроений. Сделан вывод о важности роли участия школьников в жизни города, области и страны в целом в военный период.
ЭТНОКУЛЬТУРНЫЕ АСПЕКТЫ ИЗУЧЕНИЯ КЫРГЫЗСКОГО НАЦИЕСТРОИТЕЛЬСТВА
Creators: name: А. С. Кочкунов
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: этнокультурные
нациестроительство
кыргызский
этапы
язык
идентичность
советский
нация
политика

description: В статье исследуются этнокультурные аспекты нациестроительства у кыргызского народа. Рассматриваются этапы нациестроительного процесса со времен вхождения кыргызского народа в состав Российской империи и до обретения государственной независимости в результате распада СССР. Выделяется и анализируется основное содержание каждого этапа, выявляются этнокультурные аспекты нациестроительства у кыргызского народа. В ходе проведенного исследования были получены следующие результаты: установлены этапы кыргызского нациестроительства, определены задачи и результаты нациестроительства на каждом из этапов. Сделан вывод о том, что советский этап нациестроительства имел системный и всеобъемлющий характер, что привело к формированию кыргызской нации европейского типа. Также сделан вывод, что постсоветский этап кыргызского нациестроительства имеет особенности, протекает в условиях формирования общегражданской политической идентичности.
Thermals Forecast with Temps
Creators: name: Predelli, Oliver
Publisher: name: arXiv
Year: 2022
Subjects: subject: Atmospheric and Oceanic Physics (physics.ao-ph)
subject: FOS: Physical sciences

description: This paper describes a simple method for estimating the strength of a thermal updraft from a Temp (i.e., a SkewT, Emagram, or similar) showing the temperature and dew point profile of the lower atmosphere. The data of the Temp can come from relevant weather models or from radiosondes.
description: This is the English translation of an article that originally appeared in the German language journal "segelfliegen magazin"
Electromagnetic Torques, Precession and Evolution of Magnetic Inclination of Pulsars
Creators: name: Zanazzi, J. J.
name: Lai, Dong
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present analytic calculations of the electromagnetic torques acting on a magnetic neutron star rotating in vacuum, including near-zone torques associated with the inertia of dipole and quadrupole magnetic fields. We incorporate these torques into the rotational dynamics of a rigid-body neutron star, and show that the effects of the inertial torque can be understood as a modification of the moment of inertia tensor of the star. We apply our rotational dynamics equation to the Crab pulsar, including intrinsic distortions of the star and various electromagnetic torques, to investigate the possibility that the counter-alignment of the magnetic inclination angle, as suggested by recent observations, could be explained by pulsar precession. We find that if the effective principal axis of the pulsar is nearly aligned with either the magnetic dipole axis or the rotation axis, then precession may account for the observed counter-alignment over decade timescales. Over the spindown timescale of the pulsar, the magnetic inclination angle always decreases.
description: 10 pages, 6 figures
ИССЛЕДОВАНИЕ И РЕШЕНИЕ ПРОБЛЕМ КУЛЬТУРЫ В ПОЛИПРЕДМЕТНОМ ПРОСТРАНСТВЕ РЕГИОНА
Creators: name: В. И. Ионесов
Publisher: name: Международный журнал гуманитарных и естественных наук
Year: 2020
Subjects: экономика
культура
инновации
образование
проблемы
предложения
игровые технологии.

description: В рамках культурного пространства региона возникают противоречия, трудности, барьеры, переходящие в проблемы, которые необходимо исследовать и решать. Для их выявления, формулирования и разрешения существуют игровые имитационные технологии. Представлены технология, этапы, сценарий и показатели проведения проблемно-ситуационных игр, как инструмента исследования проблем и их разрешения для повышения эффективности культурного пространства региона.
Describing the practical – equity and parity in metadata for practice research
Creators: name: Vials Moore, Adam
name: Evans, Jenny
name: Stone, Alan
name: Kotarski, Rachael
Publisher: name: Zenodo
Year: 2023
Subjects: practice research
metadata
schema
taxonomy
niso plus 2023
repositories

description: We will describe our recent work on evolving a metadata schema within a repository that includes rich support for practice research and detailing the contributions of all those involved in the work. This work was performed in a co-production with researchers and infrastructure stakeholders. Key findings have produced recommendations including the below: • Agreeing on and articulating a standard for sharing practice research objects will increase the perception of their value in research recognition and evaluation mechanisms, and the wider scholarly landscape. Improving their capture, preservation and discovery will underwrite an improved sharing culture in the community • A Practice Research platform needs to be an interactive service that reflects form and function (beauty) and enables discoverability, citation and preservation of practice research. It must be embedded in the community and the digital spaces that they work within Addressing these recommendations will ensure a better environment for all research, not just practice. Following on from describing the project and these recommendations we will facilitate a discussion on capturing the attendees’ own perspectives and experiences to further enrich approaches and inform work arising from relevant initiatives
 Please list up to three questions or issues that your session will address * How do we ensure there is a pragmatic synthesis from the rich descriptive information in A&H repositories to a common ontology in global metadata? How do we ensure metadata schema embrace parity for all research, across disciplines? How do we take these schema and enable repositories to be places where research is preserved, accessed, discovered, and most importantly, used and built upon?