cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Do we care about the distance to the CMB? Clarifying the impact of second-order lensing
Creators: name: Bonvin, Camille
name: Clarkson, Chris
name: Durrer, Ruth
name: Maartens, Roy
name: Umeh, Obinna
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: It has recently been shown that second-order corrections to the background distance-redshift relation can build up significantly at large redshifts, due to an aggregation of gravitational lensing events. This shifts the expectation value of the distance to the CMB by 1%. In this paper we show that this shift is already properly accounted for in standard CMB analyses. We clarify the role that the area distance to the CMB plays in the presence of second-order lensing corrections.
description: 15 pages, no figure; v2: some typos and an error in eq. (20) (v1) corrected. Conclusion unchanged; v3: reference added, minor changes to the text, matches published version
Ferroelectric quantum phase transition with cold polar molecules
Creators: name: Klinsmann, Markus
name: Peter, David
name: Büchler, Hans Peter
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We analyze a system of polar molecules in a one-dimensional optical lattice. By controlling the internal structure of the polar molecules with static electric and microwave fields, we demonstrate the appearance of a quantum phase transition into a ferroelectric phase via spontaneous breaking of a $U(1)$ symmetry. The phase diagram is first analyzed within mean-field theory, while in a second step the results are verified by a mapping onto the Bose-Hubbard model for hard-core bosons. The latter is studied within the well-established bosonization procedure. We find that the ferroelectric phase is characterized by (quasi) long-range order for the electric dipole moments.
description: 8 pages, 3 figures
title: How can a façade design enhance daylight in office environments in temperate climates?: An energy-efficient approach toward sustainability
Creators: name: Attri, Mohit
Publisher: name: University of Southampton
Year: 2022
Subjects: eco-friendly, energy efficient, daylight, CO2 emissions, retrofit

description: Making a structure eco-friendly and energy efficient should be one of the foremost requirements during the design phase so that it not only fulfills the needs of the present but also satisfies the demands of the future. Daylighting is one of the most critical areas to fulfil the above requirements. Recent studies highlight that in Europe, 70% of the office buildings' lighting consumption is fulfilled by electricity resulting in additional energy requirements and CO2 emissions. This paper explains the role of daylighting in achieving energy savings by presenting different shading schemes to effectively daylight the space and also tries to find a way to minimise the use of artificial lighting by using different mitigation strategies. Annual glare, UDI (Useful Daylight Illuminance) and Daylight Autonomy have been used to quantify the impact of these strategies. Euston Tower, a 70s office building is analysed as part of this Thesis to present an alternative façade retrofit proposal.
The Study of Trimbakeshwar Tourist Center with Satisfaction Index, Nashik District, Maharashtra.
Creators: name: Dr. Mohan Kisan Shelar
Publisher: name: Zenodo
Year: 2022
Subjects: Tourist, Satisfaction Index,Trimbakeshwar tourist Center, Satisfaction level etc.

description: Abstract :- Tourism is considered an important factor in the economy of many Countries. Tourism is a tertiary activity that has increased in India as well as in Maharashtra in the recent period. The aim of this research paper is to understand the satisfaction level of tourist at the Trimbakeshwar tourist Center with different facilities. The information in this study comes from primary source. Primary data was gathered in the study region through field work and visit. A questionnaire, Observation and conversation through personal interviews are also used to collect primary data. Over all 197 questionnaire, where filled by tourist. The functional and behaviour Characteristic of the tourist are important for the future planning and development of the tourist Center. The response of the tourist where transformed into arithmetical value to calculate the satisfaction level’s of Selected 15th facilities. On the basis of this evolution levels of satisfaction by tourist where classified into four stages, such as excellent, good, satisfactory and unsatisfactory. Discussion of present satisfaction level of Trimbakeshwar tourist Center is Satisfactory with the average score of 36.14 %. Average satisfaction index value for Trimbakeshwar tourist Center would be very useful for future planning and development of this tourist Center.
Quartierspiegel Wollishofen 2020
Creators: name: (:Unkn) Unknown
Publisher: name: Zentralbibliothek Zürich
Year: 2020
Subjects: subject: 314 Allgemeine Statistiken zu Europa
subject: 710 Städtebau, Raumplanung, Landschaftsgestaltung
subject: 949 Geschichte anderer Teile Europas
subject: Zürich-Wollishofen
subject: Zürich / Kreis 2
subject: Quartier
subject: Amtliche Statistik
subject: Bevölkerungsstatistik

description: Die in dieser Ausgabe publizierten Daten beziehen sich zum grössten Teil auf folgenden Zeitabschnitt : 2019
description: Von den Pfahlbauern zu den Alemannen, von den Wohnbaugenossenschaften zur geplanten «Greencity»: Wollishofen war schon immer eine stark vom Wohnen geprägte Gegend. Doch dass die wohlhabende Gemeinde Ende des 19. Jahrhunderts überhaupt Teil der Stadt Zürich wurde, geschah gegen den erbitterten Widerstand seiner Bewohnerinnen und Bewohner.
Cheetah - OVERALL PROGRESS REPORT (January 2019 – June 2020)
Creators: name: Guerini, Massimiliano
name: Butticè, Vincenzo
name: Mancuso, Raffaele
Publisher: name: Zenodo
Year: 2020
Subjects: CHEETAH

description: Overall progress report of RISIS DATASET CHEETAH. Reporting period 1 (January 2019 – June 2020).
VICO - OVERALL PROGRESS REPORT (January 2019 – June 2020)
Creators: name: Tenca, Francesca
name: Montanaro, Benedetta
name: Guerini, Massimiliano
Publisher: name: Zenodo
Year: 2020
Subjects: VICO

description: Overall Progress Report of RISIS DATASET VICO. Reporting period 1 (January 2019 – June 2020).
First-principles study of two-dimensional van der Waals heterojunctions
Creators: name: Hu, Wei
name: Yang, Jinlong
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Research on graphene and other two-dimensional (2D) materials, such as silicene, germanene, phosphorene, hexagonal boron nitride (h-BN), graphitic carbon nitride (g-C3N4), graphitic zinc oxide (g-ZnO) and molybdenum disulphide (MoS2), has recently received considerable interest owing to their outstanding properties and wide applications. Looking beyond this field, combining the electronic structures of 2D materials in ultrathin van der Waals heterojunctions has also emerged to widely study theoretically and experimentally to explore some new properties and potential applications beyond their single components. Here, this article reviews our recent theoretical studies on the structural, electronic, electrical and optical properties of 2D van der Waals heterojunctions using density functional theory calculations, including the Graphene/Silicene, Graphene/Phosphorene, Graphene/g-ZnO, Graphene/MoS2 and g-C3N4/MoS2 heterojunctions. Our theoretical simulations, designs and calculations show that novel 2D van der Waals heterojunctions provide a promising future for electronic, electrochemical, photovoltaic, photoresponsive and memory devices in the experiments.
description: 12 pages, 5 figures in Computational Materials Science (2015). arXiv admin note: text overlap with arXiv:1411.0357
Frictional dynamics of viscoelastic solids driven on a rough surface
Creators: name: Landes, Francois P.
name: Rosso, Alberto
name: Jagla, E. A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We study the effect of viscoelastic dynamics on the frictional properties of a (mean field) spring-block system pulled on a rough surface by an external drive. When the drive moves at constant velocity V, two dynamical regimes are observed: at fast driving, above a critical threshold Vc, the system slides at the drive velocity and displays a friction force with velocity weakening. Below Vc the steady sliding becomes unstable and a stick-slip regime sets in. In the slide-hold-slide driving protocol, a peak of the friction force appears after the hold time and its amplitude increases with the hold duration. These observations are consistent with the frictional force encoded phenomenologically in the rate-and-state equations. Our model gives a microscopical basis for such macroscopic description.
description: 10 figures, 7 pages, +4 pages of appendix
Online Appendixes for Productivity Impulses from Regional Integration: Lessons from Road Openings
Creators: name: Holmen, Rasmus Bøgh
Publisher: name: Zenodo
Year: 2022
Subjects: urban economics; rural economics; infrastructure, productivity; wider economic impacts; market access; road constructions; transportation appraisal

description: Online Appendixes for a paper: Holmen, R. B. (2022). Productivity Impulses from Regional Integration: Lessons from Road Openings. Insights into Regional Development, 4(4), 83-125. http://doi.org/10.9770/IRD.2022.4.4(6)
Spin-transfer torque effects in the dynamic forced response of the magnetization of nanoscale ferromagnets in superimposed ac and dc bias fields in the presence of thermal agitation
Creators: name: Byrne, D. J.
name: Coffey, W. T.
name: Kalmykov, Y. P.
name: Titov, S. V.
name: Wegrowe, J. E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Spin-transfer torque (STT) effects on the stationary forced response of nanoscale ferromagnets subject to thermal fluctuations and driven by an ac magnetic field of arbitrary strength and direction are investigated via a generic nanopillar model of a spin-torque device comprising two ferromagnetic strata representing the free and fixed layers and a nonmagnetic conducting spacer all sandwiched between two ohmic contacts. The STT effects are treated via the Brown magnetic Langevin equation generalized to include the Slonczewski STT term thereby extending the statistical moment method [Y. P. Kalmykov et al., Phys. Rev. B 88, 144406 (2013)] to the forced response of the most general version of the nanopillar model. The dynamic susceptibility, nonlinear frequency-dependent dc magnetization, dynamic magnetic hysteresis loops, etc. are then evaluated highlighting STT effects on both the low-frequency thermal relaxation processes and the high-frequency ferromagnetic resonance, etc., demonstrating a pronounced dependence of these on the spin polarization current and facilitating interpretation of STT experiments.
Efficiency of Human Activity on Information Spreading on Twitter
Creators: name: Morales, A. J
name: Borondo, J.
name: Losada, J. C.
name: Benito, R. M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Social and Information Networks (cs.SI)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Understanding the collective reaction to individual actions is key to effectively spread information in social media. In this work we define efficiency on Twitter, as the ratio between the emergent spreading process and the activity employed by the user. We characterize this property by means of a quantitative analysis of the structural and dynamical patterns emergent from human interactions, and show it to be universal across several Twitter conversations. We found that some influential users efficiently cause remarkable collective reactions by each message sent, while the majority of users must employ extremely larger efforts to reach similar effects. Next we propose a model that reproduces the retweet cascades occurring on Twitter to explain the emergent distribution of the user efficiency. The model shows that the dynamical patterns of the conversations are strongly conditioned by the topology of the underlying network. We conclude that the appearance of a small fraction of extremely efficient users results from the heterogeneity of the followers network and independently of the individual user behavior.
description: 29 pages, 10 figures
BdSL47: A complete dataset of sign alphabet and digits of Bangla Sign Language (BdSL) using depth information via MediaPipe
Creators: name: Rayeed, S. M.
Publisher: name: Zenodo
Year: 2022
Subjects: Bangla Sign Language
Depth Information
Hand Gesture Recognition
Sign Language Recognition
Bangla Sign Digits
Bangla Sign Alphabet

description: BdSL47 is the first open-access complete dataset in Bangla Sign Language that contains hand signs from both 10 sign digits (from sign ০ to sign ৯) and 37 sign alphabet (from sign অ to sign ँ). Dataset summary : 100 RGB images per sign (total 47 signs) from each of 10 users Total input images : 100×47×10 = 47000 Input images are processed via MediaPipe, which provided an output image with hand key-points being detected 3D coordinate values of 21 predefined key-points Total 63 coordinate values for each sample The values are stored in csv files 1 CSV file contains values from 100 samples of 1 sign from 1 user Total CSV files : 47×10 = 470 The dataset has been made public for further research purposes. It is also available upon request here.
description: Funding provided by: Institute for Advanced Research*
Crossref Funder Registry ID:
Award Number: UIU-IAR-01-2022-SE-37Funding provided by: United International University
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100019458
Award Number: UIU-IAR-01-2022-SE-37
Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery
Creators: name: Chiarella, A.M.
name: Butler, K.V.
name: Hathaway, N.A.
name: Pomella, S.
name: Lu, D.
name: Jin, J.
name: Yu, X.
name: Wang, T.A.
name: Gryder, B.E.
name: Khan, J.
Publisher: name: Nature Research
Year: 2020

description: Gene expression can be activated or suppressed using CRISPR­–Cas9 systems. However, tools that enable dose-dependent activation of gene expression without the use of exogenous transcription regulatory proteins are lacking. Here we describe chemical epigenetic modifiers (CEMs) designed to activate the expression of target genes by recruiting components of the endogenous chromatin-activating machinery, eliminating the need for exogenous transcriptional activators. The system has two parts: catalytically inactive Cas9 (dCas9) in complex with FK506-binding protein (FKBP) and a CEM consisting of FK506 linked to a molecule that interacts with cellular epigenetic machinery. We show that CEMs upregulate gene expression at target endogenous loci up to 20-fold or more depending on the gene. We also demonstrate dose-dependent control of transcriptional activation, function across multiple diverse genes, reversibility of CEM activity and specificity of our best-in-class CEM across the genome.
Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma
Creators: name: Stanton, B.Z.
name: Rota, R.
name: Walton, A.
name: Chou, H.-C.
name: Vakoc, C.R.
name: Shern, J.F.
name: Chen, J.
name: Wen, X.
name: Wu, X.S.
name: Chiarella, A.M.
name: Pomella, S.
name: Gryder, B.E.
name: Song, Y.
name: Khan, J.
name: Bagchi, S.
name: Sinniah, R.S.
name: Zhao, K.
name: Hathaway, N.A.
name: Sayers, C.
Publisher: name: Nature Research
Year: 2019

description: Core regulatory transcription factors (CR TFs) orchestrate the placement of super-enhancers (SEs) to activate transcription of cell-identity specifying gene networks, and are critical in promoting cancer. Here, we define the core regulatory circuitry of rhabdomyosarcoma and identify critical CR TF dependencies. These CR TFs build SEs that have the highest levels of histone acetylation, yet paradoxically the same SEs also harbor the greatest amounts of histone deacetylases. We find that hyperacetylation selectively halts CR TF transcription. To investigate the architectural determinants of this phenotype, we used absolute quantification of architecture (AQuA) HiChIP, which revealed erosion of native SE contacts, and aberrant spreading of contacts that involved histone acetylation. Hyperacetylation removes RNA polymerase II (RNA Pol II) from core regulatory genetic elements, and eliminates RNA Pol II but not BRD4 phase condensates. This study identifies an SE-specific requirement for balancing histone modification states to maintain SE architecture and CR TF transcription.
Racial microaggressions: Their effects on mental and physical health
Creators: name: Alabi, Jaena
Publisher: name: Network of the National Library of Medicine, Region 4
Year: 2022
Subjects: racial microaggressions

description: In this webinar session, Jaena Alabi will present a brief history of racial microaggressions research, focusing on the negative mental and physical health outcomes associated with experiencing subtle racism. Strategies for mitigating the negative effects of racial microaggressions, such as incorporating cultural competence into one’s practice, will also be shared.
Fighting Fire with Fire? Inequality, Populism and Voter Turnout
Creators: name: Schwander, Hanna
name: Gohla, Dominic
name: Schäfer, Armin
Publisher: name: Humboldt-Universität zu Berlin
Year: 2020
Subjects: subject: Voter turnout
subject: Populism
subject: Inequality
subject: Participation
subject: Political sociology
subject: Wahlbeteiligung
subject: Populismus
subject: Ungleichheit
subject: Politische Soziologie
subject: 320 Politikwissenschaft (Politik und Regierung)

description: In this article, we ask whether the presence of populist parties influences the negative effect of income inequality on voter turnout. A number of studies have shown that voter turnout is lower in unequal countries. In particular, citizens with fewer resources abstain at higher rates. Since populist parties seek to mobilize these groups, their success could lead to higher and less unequal turnout rates. To assess empirically whether this holds true, we analyzed a dataset encompassing data on 296 national parliamentary elections in 31 European countries between 1970 and 2016. The results show that there is neither a direct nor an indirect effect of populism on voter turnout. In elections with more successful populist parties, voter turnout was not significantly higher than in other elections. Higher vote shares of populist parties also do not mitigate the negative impact of income inequality on voter turnout. Finally, there does not seem to be a difference between elections with high left-wing or right-wing populist parties’ success. Neither variant of populism alters the relationship between inequality and turnout.
description: In diesem Beitrag wird die Frage gestellt, ob populistische Parteien den negativen Zusammenhang zwischen Einkommensungleichheit und der Höhe der Wahlbeteiligung beeinflussen. Eine Reihe von Studien hat gezeigt, dass die Wahlbeteiligung in ungleichen Ländern niedriger ausfällt. Vor allem Bürgerinnen und Bürger mit weniger Ressourcen bleiben dort häufiger am Wahltag zu Hause. Da populistische Parteien darauf abzielen, jene Gruppen zu mobilisieren, die eine höhere Wahrscheinlichkeit haben, nicht zu wählen, könnte ihr Erfolg zu einer höheren und weniger ungleichen Wahlbeteiligung führen. Um diesen möglichen Zusammenhang empirisch zu überprüfen, wurde ein Datensatz von Informationen über 296 Parlamentswahlen in 31 europäischen Ländern für den Zeitraum von 1970 bis 2016 analysiert. Die Ergebnisse zeigen jedoch, dass weder ein direkter noch ein indirekter Zusammenhang zwischen Populismus und Wahlbeteiligung besteht. Schneiden populistische Parteien besonders gut ab, fällt die Wahlbeteiligung nicht höher aus. Hohe Stimmenanteile dieser Parteien mildern auch nicht den negativen Zusammenhang zwischen Ungleichheit und Wahlbeteiligung ab. Schließlich konnten auch keine unterschiedlichen Effekte zwischen links- und rechtspopulistischen Parteien gefunden werden. Keine der beiden Varianten verändert die grundlegenden Zusammenhang zwischen Einkommensungleichheit und der Höhe der Wahlbeteiligung.
Department Management System for Departments of Sri Lankan Universities
Creators: name: Thuseethan, S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computers and Society (cs.CY)
subject: FOS: Computer and information sciences

description: This paper proposes a new method of data handling as well as implementation of management system for an academic department. Management system is a proven framework for managing and continually improving the organizations policies, procedures and processes. Department of Sri Lankan Universities is a division within a faculty comprising one subject area or a number of related subject areas. The time consumption and error rate of producing information is extremely high. This paper describes how to do the data handling in a department of Sri Lankan Universities using the management system. The efficiency of the management system measured with the amount of data handled by the department. Experiment results shows that this method of data handling increase the efficiency of the department in terms of processing information and the reduction of risks involved with the department activities.
Further Results on Lyapunov-Like Conditions of Forward Invariance and Boundedness for a Class of Unstable Systems
Creators: name: Gorban, A. N.
name: Tyukin, I. Yu.
name: Nijmeijer, H.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 37B25

description: We provide several characterizations of convergence to unstable equilibria in nonlinear systems. Our current contribution is three-fold. First we present simple algebraic conditions for establishing local convergence of non-trivial solutions of nonlinear systems to unstable equilibria. The conditions are based on the earlier work (A.N. Gorban, I.Yu. Tyukin, E. Steur, and H. Nijmeijer, SIAM Journal on Control and Optimization, Vol. 51, No. 3, 2013) and can be viewed as an extension of the Lyapunov's first method in that they apply to systems in which the corresponding Jacobian has one zero eigenvalue. Second, we show that for a relevant subclass of systems, persistency of excitation of a function of time in the right-hand side of the equations governing dynamics of the system ensure existence of an attractor basin such that solutions passing through this basin in forward time converge to the origin exponentially. Finally we demonstrate that conditions developed in (A.N. Gorban, I.Yu. Tyukin, E. Steur, and H. Nijmeijer, SIAM Journal on Control and Optimization, Vol. 51, No. 3, 2013) may be remarkably tight.
description: 53d IEEE Conference on Decision and Control, Los-Angeles, USA, 2014
Deferiprone: Pan-selective Histone Lysine Demethylase Inhibition Activity and Structure Activity Relationship Study
Creators: name: Sanghani, B.A.
name: Oyelere, A.K.
name: MacDonald, I.A.
name: Bridges, A.
name: Rajpurohit, P.
name: Ho, P.-Y.
name: Fan, Y.
name: Khodaverdian, V.
name: Thangaraju, M.
name: Hathaway, N.A.
name: Xu, Y.
name: Tapadar, S.
Publisher: name: Nature Publishing Group
Year: 2019

description: Deferiprone (DFP) is a hydroxypyridinone-derived iron chelator currently in clinical use for iron chelation therapy. DFP has also been known to elicit antiproliferative activities, yet the mechanism of this effect has remained elusive. We herein report that DFP chelates the Fe 2+ ion at the active sites of selected iron-dependent histone lysine demethylases (KDMs), resulting in pan inhibition of a subfamily of KDMs. Specifically, DFP inhibits the demethylase activities of six KDMs - 2A, 2B, 5C, 6A, 7A and 7B - with low micromolar IC 50 s while considerably less active or inactive against eleven KDMs - 1A, 3A, 3B, 4A-E, 5A, 5B and 6B. The KDM that is most sensitive to DFP, KDM6A, has an IC 50 that is between 7- and 70-fold lower than the iron binding equivalence concentrations at which DFP inhibits ribonucleotide reductase (RNR) activities and/or reduces the labile intracellular zinc ion pool. In breast cancer cell lines, DFP potently inhibits the demethylation of H3K4me3 and H3K27me3, two chromatin posttranslational marks that are subject to removal by several KDM subfamilies which are inhibited by DFP in cell-free assay. These data strongly suggest that DFP derives its anti-proliferative activity largely from the inhibition of a sub-set of KDMs. The docked poses adopted by DFP at the KDM active sites enabled identification of new DFP-based KDM inhibitors which are more cytotoxic to cancer cell lines. We also found that a cohort of these agents inhibited HP1-mediated gene silencing and one lead compound potently inhibited breast tumor growth in murine xenograft models. Overall, this study identified a new chemical scaffold capable of inhibiting KDM enzymes, globally changing histone modification profiles, and with specific anti-tumor activities.
WOMEN LEADERSHIP IN INDIA: THE CHANGING LANDSCAPE
Creators: name: Ms. Shweta Audichya Dr Deepti Bhargava
Publisher: name: Zenodo
Year: 2022
Subjects: Indian women, Stereotypes, Barriers, Leadership.

description: ABSTRACT This study examined how Indian male and female managers perceived and used leadership styles and civility techniques in professional settings. The employment of politeness strategies and male and female leadership styles have been heavily researched in the Western context, but this research is lacking in the dynamically changing Indian setting, where society has historically been hierarchical and very paternalistic. The number of Indian women holding executive roles in the workforce has steadily increased, creating new linguistic settings. The purpose of this study is to increase public understanding of both the potential and difficulties that women managers encounter in patriarchal societies. This study shows that gender stereotypes still exist in the workplace in India because it is thought that female leadership goes against patriarchal culture and traditional religious beliefs. Gender stereotypes, patriarchy, and religious beliefs continue to devalue, degrade, and limit women. On the other hand, female managers excelled at presiding over meetings. Despite the dual roles that Indian women were required to play as mothers, wives, and professionals, they outperformed male managers. This shows that gender roles are evolving and that the paternalistic society of Indonesia is being influenced by global factors.
Pathway-Based High-Throughput Chemical Screen Identifies Compounds That Decouple Heterochromatin Transformations
Creators: name: Jin, J.
name: MacDonald, I.A.
name: Yelagandula, R.
name: Graves, L.M.
name: Clinkscales, S.E.
name: Bell, O.
name: Hathaway, N.A.
name: Herring, L.E.
name: Stecher, K.
name: Butler, K.V.
Publisher: name: SAGE Publications Inc.
Year: 2019

description: Heterochromatin protein 1 (HP1) facilitates the formation of repressive heterochromatin domains by recruiting histone lysine methyltransferase enzymes to chromatin, resulting in increased levels of histone H3K9me3. To identify chemical inhibitors of the HP1-heterochromatin gene repression pathway, we combined a cell-based assay that utilized chemical-mediated recruitment of HP1 to an endogenous active gene with high-throughput flow cytometry. Here we characterized small molecule inhibitors that block HP1-mediated heterochromatin formation. Our lead compounds demonstrated dose-dependent inhibition of HP1-stimulated gene repression and were validated in an orthogonal cell-based system. One lead inhibitor was improved by a change in stereochemistry, resulting in compound 2, which was further used to decouple the inverse relationship between H3K9 and H3K4 methylation states. We identified molecular components that bound compound 2, either directly or indirectly, by chemical affinity purification with a biotin-tagged derivative, followed by quantitative proteomic techniques. In summary, our pathway-based chemical screening approach resulted in the discovery of new inhibitors of HP1-mediated heterochromatin formation while identifying exciting new molecular interactions in the pathway to explore in the future. This modular platform can be expanded to test a wide range of chromatin modification pathways yielding inhibitors that are cell permeable and function in a physiologically relevant setting.
Multiple scattering theory for superconducting heterostructures
Creators: name: Csire, Gábor
name: Újfalussy, Balázs
name: Cserti, József
name: Győrffy, Balázs
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We generalize the screened Korringa-Kohn-Rostoker (SKKR) method for solving the corresponding Kohn-Sham-Bogoliubov-de Gennes (KSBdG) equations for surfaces and interfaces. As an application of the newly developed theory we study the quasiparticle spectrum of Au overlayers on a Nb(100) host. We find that, within the superconducting gap region, the quasiparticle spectrum consists of Andreev bound states (ABS) with a dispersion which is closely connected to the underlying electronic structure of the overlayer. We also find that the spectrum has a strongly k-dependent induced gap. The properties of the gap is discussed in relation to the thickness of the overlayer, and it is shown that certain states do not participate in the Andreev scattering process.
description: 11 pages, 7 figures
Chemical screen for epigenetic barriers to single allele activation of Oct4
Creators: name: Alejo, A.
name: Headley, K.M.
name: Purvis, J.E.
name: Lai, E.Z.-X.
name: Hathaway, N.A.
name: Kedziora, K.M.
Publisher: name: Elsevier B.V.
Year: 2019

description: Here we utilized the chromatin in vivo assay (CiA) mouse platform to directly examine the epigenetic barriers impeding the activation of the CiA:Oct4 allele in mouse embryonic fibroblasts (MEF)s when stimulated with a transcription factor. The CiA:Oct4 allele contains an engineered EGFP reporter replacing one copy of the Oct4 gene, with an upstream Gal4 array in the promoter that allows recruitment of chromatin modifying machinery. We stimulated gene activation of the CiA:Oct4 allele by binding a transcriptional activator to the Gal4 array. As with cellular reprograming, this process is inefficient with only a small percentage of the cells re-activating CiA:Oct4 after weeks. Epigenetic barriers to gene activation potentially come from heavy DNA methylation, histone deacetylation, chromatin compaction, and other posttranslational marks (PTM) at the differentiated CiA:Oct4 allele in MEFs. Using this platform, we performed a high-throughput chemical screen for compounds that increased the efficiency of activation. We found that Azacytidine and newer generation histone deacetylase (HDAC) inhibitors were the most efficient at facilitating directed transcriptional activation of this allele. We found one hit form our screen, Mocetinostat, improved iPSC generation under transcription factor reprogramming conditions. These results separate individual allele activation from whole cell reprograming and give new insights that will advance tissue engineering.
Identifizierung der Natur aktiver Chromkatalysatoren in der Tetramerisierung von Ethen mittels in situ Spektroskopie
Creators: name: Grauke, Reni Marie Elise
Publisher: name: Universität Rostock
Year: 2019
Subjects: subject: 540 Chemistry & allied sciences

description: Die 1-Octen-Selektivität ist stark abhängig von der Natur des Präkusors, des Aktivators und des Liganden. Für die Katalysatorentwicklung sind genaue Informationen über die Bildung der tatsächlich aktiven Komplexe und deren Einfluss auf die katalytische Leistung erforderlich. Ziel ist es, die Wirkung von verschiedenen AlR3-Aktivatoren, Liganden und unterschiedlichen Präkursoren auf die Natur der katalytisch aktiven Cr-Spezies zu analysieren mit Hilfe einer maßgeschneiderten Kombination spektroskopischer In-situ-Methoden.
A Luminous Red Nova in M31 and its Progenitor System
Creators: name: Williams, S. C.
name: Darnley, M. J.
name: Bode, M. F.
name: Steele, I. A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present observations of M31LRN 2015 (MASTER OT J004207.99+405501.1), discovered in M31 in 2015 January, and identified as a rare and enigmatic luminous red nova (LRN). Spectroscopic and photometric observations obtained by the Liverpool Telescope showed the LRN becoming extremely red as it faded from its M(V) = -9.4 +/- 0.2 peak. Early spectra showed strong Halpha emission that weakened over time as a number of absorption features appeared, including Na I D and Ba II. At later times strong TiO absorption bands were also seen. A search of archival Hubble Space Telescope data revealed a luminous red source to be the likely progenitor system, with pre-outburst Halpha emission also detected in ground-based data. The outburst of M31LRN 2015 shows many similarities, both spectroscopically and photometrically, with that of V838 Mon, the best studied LRN. We finally discuss the possible progenitor scenarios.
description: 5 pages, 3 figures, 1 table, accepted for publication in the Astrophysical Journal Letters. Some minor changes, clarification, and additional references following feedback and the typesetting stage of publication
COVID-19 risk perception and hoax beliefs in the US immediately before and after the announcement of President Trump's diagnosis.
Creators: name: Tanase, Lisa-Maria
name: Kerr, John
name: Freeman, Alexandra L J
name: Schneider, Claudia R
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Misinformation
Risk Perception
Covid-19

description: A notable challenge of the SARS-CoV-2 pandemic has been public scepticism over the severity of the disease, or even its existence. Such scepticism is politically skewed in the USA, with conservatives more likely to downplay or deny the risks of the virus. However, the hospitalization of President Trump with COVID-19 in October 2020 served as a high-profile exemplar of the reality and risks of the virus, and as such may have influenced opinions, particularly for US conservatives. We investigate whether President Trump testing positive was associated with changes in public attitudes towards the virus. In two studies, we surveyed independent representative US samples before and after the announcement of Trump's illness. In Study 1, measuring risk perceptions of the virus, we find that participants surveyed before and after the announcement did not differ in their risk perception regardless of political orientation. In Study 2, measuring belief that the virus is a hoax, we find that among those on the far right of the political spectrum, hoax belief was lower for those surveyed after the announcement, suggesting that Trump's hospitalization may have affected the beliefs of those most receptive to the President's earlier suggestions that the virus might be a hoax.
Contribution of promoter DNA sequence to heterochromatin formation velocity and memory of gene repression in mouse embryo fibroblasts
Creators: name: Vignaux, P.A.
name: Bregio, C.
name: Hathaway, N.A.
Publisher: name: Public Library of Science
Year: 2019

description: Durable gene silencing through the formation of compact heterochromatin domains plays a critical role during mammalian development in establishing defined tissues capable of retaining cellular identity. Hallmarks of heterochromatin gene repression are the binding of heterochromatin protein 1 (HP1), trimethylation of lysine 9 on histone H3 (H3K9me3) and the methylation of cytosine residues of DNA. HP1 binds directly to the H3K9me3 histone modification, and while DNA methyltransferases have been found in complex with histone methyltransferases and HP1, there remains much to be known about the relationship between DNA sequence and HP1 in differentiated mammalian cells. To further explore this interplay in a controlled system, we designed a system to test the effect of promoter CpG content on the formation kinetics and memory of an HP1-mediated heterochromatin domain in mouse embryo fibroblasts (MEF)s. To do this, we have constructed a side-by-side comparison of wild-type (CpGFull) and CpG-depleted (CpGDep) promoter-driven reporter constructs in the context of the Chromatin in vivo Assay (CiA), which uses chemically-induced proximity (CIP) to tether the chromoshadow domain of HP1α (csHP1α) to a fluorescent reporter gene in a reversible, chemically-dependent manner. By comparing the response of CpGFull and CpGDep reporter constructs, we discovered that the heterochromatin formation by recruitment of csHP1α is unaffected by the underlying CpG dinucleotide content of the promoter, as measured by the velocity of gene silencing or enrichment of H3K9me3 at the silenced gene. However, recovery from long-term silencing is measurably faster in the CpG-depleted reporter lines. These data provide evidence that the stability of the HP1 heterochromatin domain is reliant on the underlying DNA sequence. Moreover, these cell lines represent a new modular system with which to study the effect of the underlying DNA sequences on the efficacy of epigenetic modifiers. © 2019 Vignaux et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
An adapting auditory-motor feedback loop can contribute to generating vocal repetition
Creators: name: Wittenbach, Jason
name: Bouchard, Kristofer E.
name: Brainard, Michael S.
name: Jin, Dezhe Z.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Neurons and Cognition (q-bio.NC)
subject: FOS: Biological sciences

description: Consecutive repetition of actions is common in behavioral sequences. Although integration of sensory feedback with internal motor programs is important for sequence generation, if and how feedback contributes to repetitive actions is poorly understood. Here we study how auditory feedback contributes to generating repetitive syllable sequences in songbirds. We propose that auditory signals provide positive feedback to ongoing motor commands, but this influence decays as feedback weakens from response adaptation during syllable repetitions. Computational models show that this mechanism explains repeat distributions observed in Bengalese finch song. We experimentally confirmed two predictions of this mechanism in Bengalese finches: removal of auditory feedback by deafening reduces syllable repetitions; and neural responses to auditory playback of repeated syllable sequences gradually adapt in sensory-motor nucleus HVC. Together, our results implicate a positive auditory-feedback loop with adaptation in generating repetitive vocalizations, and suggest sensory adaptation is important for feedback control of motor sequences.
Nucleosome Turnover Regulates Histone Methylation Patterns over the Genome
Creators: name: Bell, O.
name: Neel, D.S.
name: Hathaway, N.A.
name: Crabtree, G.R.
name: Calarco, J.P.
name: Chory, E.J.
Publisher: name: Cell Press
Year: 2019

description: Recent studies have indicated that nucleosome turnover is rapid, occurring several times per cell cycle. To access the effect of nucleosome turnover on the epigenetic landscape, we investigated H3K79 methylation, which is produced by a single methyltransferase (Dot1l) with no known demethylase. Using chemical-induced proximity (CIP), we find that the valency of H3K79 methylation (mono-, di-, and tri-) is determined by nucleosome turnover rates. Furthermore, propagation of this mark is predicted by nucleosome turnover simulations over the genome and accounts for the asymmetric distribution of H3K79me toward the transcriptional unit. More broadly, a meta-analysis of other conserved histone modifications demonstrates that nucleosome turnover models predict both valency and chromosomal propagation of methylation marks. Based on data from worms, flies, and mice, we propose that the turnover of modified nucleosomes is a general means of propagation of epigenetic marks and a determinant of methylation valence. © 2018Previous work has revealed that “writers” and “erasers” of histone modifications play a critical role in regulating gene expression. Now, studies by Chory et al. reveal that, in addition, the patterns, kinetics, and topology of histone modifications over the genome can be shaped by the rate of nucleosome turnover.
Ring finger protein 121 is a potent regulator of adeno-associated viral genome transcription
Creators: name: Yuziuk, J.A.
name: Chiarella, A.M.
name: Tse, L.V.
name: Asokan, A.
name: Tyson, T.O.
name: Hathaway, N.A.
name: Meganck, R.M.
name: Madigan, V.J.
name: Elmore, Z.C.
Publisher: name: Public Library of Science
Year: 2019

description: Adeno-associated viruses (AAV) are Dependoparvoviruses that have shown promise as recombinant vectors for gene therapy. While infectious pathways of AAV are well studied, gaps remain in our understanding of host factors affecting vector genome expression. Here, we map the role of ring finger protein 121 (RNF121), an E3 ubiquitin ligase, as a key regulator of AAV genome transcription. CRISPR-mediated knockout of RNF121 (RNF121 KO) in different cells markedly decreased AAV transduction regardless of capsid serotype or vector dose. Recombinant AAV transduction is partially rescued by overexpressing RNF121, but not by co-infection with helper Adenovirus. Major steps in the AAV infectious pathway including cell surface binding, cellular uptake, nuclear entry, capsid uncoating and second strand synthesis are unaffected. While gene expression from transfected plasmids or AAV genomes is unaffected, mRNA synthesis from AAV capsid-associated genomes is markedly decreased in RNF121 KO cells. These observations were attributed to transcriptional arrest as corroborated by RNAPol-ChIP and mRNA half-life measurements. Although AAV capsid proteins do not appear to be direct substrates of RNF121, the catalytic domain of the E3 ligase appears essential. Inhibition of ubiquitin-proteasome pathways revealed that blocking Valosin Containing Protein (VCP/p97), which targets substrates to the proteasome, can selectively and completely restore AAV-mediated transgene expression in RNF121 KO cells. Expanding on this finding, transcriptomic and proteomic analysis revealed that the catalytic subunit of DNA PK (DNAPK-Cs), a known activator of VCP, is upregulated in RNF121 KO cells and that the DNA damage machinery is enriched at sites of stalled AAV genome transcription. We postulate that a network of RNF121, VCP and DNA damage response elements function together to regulate transcriptional silencing and/or activation of AAV vector genomes.
Quartierspiegel Hirzenbach 2020
Creators: name: (:Unkn) Unknown
Publisher: name: Zentralbibliothek Zürich
Year: 2020
Subjects: subject: 314 Allgemeine Statistiken zu Europa
subject: 710 Städtebau, Raumplanung, Landschaftsgestaltung
subject: 949 Geschichte anderer Teile Europas
subject: Zürich-Schwamendingen
subject: Quartier
subject: Amtliche Statistik
subject: Bevölkerungsstatistik

description: Die in dieser Ausgabe publizierten Daten beziehen sich zum grössten Teil auf folgenden Zeitabschnitt : 2019
description: Wie die anderen Schwamendinger Quartiere ist auch Hirzenbach stark vom genossenschaftlichen Wohnungsbau geprägt: Die quartiertypischen Zeilenbauten lassen die Idee der Gartenstadt mit ihrem grosszügigen und grünen Raumkonzept allenthalben erkennen. Inzwischen hat sich aber auch die Verbindung zur Innenstadt durch den Bahnhof Stettbach stark verbessert.
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Creators: name: dkacGs Mh-, l-
Publisher: name: Zenodo
Year: 2022

description: lkjka'k %& f’k{k.k gs lekt ifjorZukps izHkkoh lk/ku vkgs-lekt thoukaP;k xjtk vk’kk&vkdka{kk vkf.k mfn~n”V;s ;kaP;k’kh f’k{k.kkpk Qkj toGpk laca/k vkgs- lektkP;k lkekftd o lkaLd`frd fopkj izokgkuk ;ksX; oG.k ns.;kps dke f’k{k.kkps vkgs- ekuokph vfLerk o vfLrRo O;oLFkhr Bsowu R;kyk LokfHkekukus vkf.k lq[kkus tx.;kpk ekxZ nk[kfo.ks gs f’k{k.kkps egRokps dk;Z vkgs- lektkph lokZaxh.k izxrh dj.;klkBh lektkrhy rGk xkGkrhy lokZauk f’k{k.k feGkys ikfgts- i.k Hkkjrh; lektkr f’k{k.k ?ks.;kpk vf/kdkj eqBHkj yksdkauk gksrk-R;keqGs cgqtu letkrhy fo|kFkhZ f’k{k.kkiklwu oafpr gksrk-
Revealing progenitors of type Ia supernovae from their light curves and spectra
Creators: name: Kutsuna, Masamichi
name: Shigeyama, Toshikazu
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: In the single degenerate (SD) scenario of type Ia supernovae (SNe Ia), the collision of the ejecta with its companion results in stripping hydrogen rich matter from the companion star. This hydrogen rich matter might leave its trace in the light curves and/or spectra. In this paper, we perform radiation hydrodynamical simulations of this collision for three binary systems. As a result, we find that the emission from the shock-heated region is not as strong as in the previous study. This weak emission, however, may be a result of our underestimate of the coupling between the gas and radiation in the shock interaction. Therefore, though our results suggest that the observed early light curves of SNe Ia can not rule out binary systems with a short separation as the progenitor system, more elaborate numerical studies will be needed to reach a fair conclusion. Alternatively, our results indicate that the feature observed in the early phase of a recent type Ia SN 2014J might result from interaction of the ejecta with a red giant companion star. We also discuss the dependence of spectral features of H alpha and Si II absorption lines on viewing angles and investigate whether they can constrain the event rate of the SD progenitor.
description: To appear in PASJ, 24 pages, 13 figures