cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Kleine Mitteilungen
Creators: name: Redaktion, Die
Publisher: name: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts
Year: 2017

description: [nicht vorhanden / not available]
description: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts, Bd. 23, Nr. 4 (1939)
The genome and lifestage-specific transcriptomes of a plant-parasitic nematode and its host reveal susceptibility genes involved in trans-kingdom synthesis of vitamin B5.
Creators: name: Siddique, Shahid
name: Radakovic, Zoran S
name: Hiltl, Clarissa
name: Pellegrin, Clement
name: Baum, Thomas J
name: Beasley, Helen
name: Bent, Andrew F
name: Chitambo, Oliver
name: Chopra, Divykriti
name: Danchin, Etienne GJ
name: Grenier, Eric
name: Habash, Samer S
name: Hasan, M Shamim
name: Helder, Johannes
name: Hewezi, Tarek
name: Holbein, Julia
name: Holterman, Martijn
name: Janakowski, Sławomir
name: Koutsovoulos, Georgios D
name: Kranse, Olaf P
name: Lozano-Torres, Jose L
name: Maier, Tom R
name: Masonbrink, Rick E
name: Mendy, Badou
name: Riemer, Esther
name: Sobczak, Mirosław
name: Sonawala, Unnati
name: Sterken, Mark G
name: Thorpe, Peter
name: Van Steenbrugge, Joris JM
name: Zahid, Nageena
name: Grundler, Florian
name: Eves-Van Den Akker, Sebastian
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022

description: Plant-parasitic nematodes are a major threat to crop production in all agricultural systems. The scarcity of classical resistance genes highlights a pressing need to find new ways to develop nematode-resistant germplasm. Here, we sequence and assemble a high-quality phased genome of the model cyst nematode Heterodera schachtii to provide a platform for the first system-wide dual analysis of host and parasite gene expression over time, covering all major parasitism stages. Analysis of the hologenome of the plant-nematode infection site identified metabolic pathways that were incomplete in the parasite but complemented by the host. Using a combination of bioinformatic, genetic, and biochemical approaches, we show that a highly atypical completion of vitamin B5 biosynthesis by the parasitic animal, putatively enabled by a horizontal gene transfer from a bacterium, is required for full pathogenicity. Knockout of either plant-encoded or now nematode-encoded steps in the pathway significantly reduces parasitic success. Our experiments establish a reference for cyst nematodes, further our understanding of the evolution of plant-parasitism by nematodes, and show that congruent differential expression of metabolic pathways in the infection hologenome represents a new way to find nematode susceptibility genes. The approach identifies genome-editing-amenable targets for future development of nematode-resistant crops.
Over-prescription of short-acting β2-agonists is associated with poor asthma outcomes: results from the African cohort of the SABINA III study
Creators: name: Khattab, Adel
name: Madkour, Ashraf
name: Ambaram, Anish
name: Smith, Clifford
name: Muhwa, Chakaya J.
name: Mecha, Jared O.
name: Alsayed, Mohamed
name: Beekman, Maarten J. H. I.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: 60506 Virology

description: The extent of short-acting β2-agonist (SABA) overuse in Africa remains poorly documented. As part of the SABA use IN Asthma (SABINA) III study, we assessed SABA prescriptions/clinical outcomes in 3 African countries. Data on disease characteristics/asthma treatments were collected from patients (≥12 years) using electronic case report forms. Patients were classified by investigator-defined asthma severity (guided by the 2017 Global Initiative for Asthma) and practice type (primary/specialist care). Multivariable regression models analyzed associations between SABA prescriptions and outcomes. Data from 1778 patients (mean age, 43.7 years) were analyzed. Most patients were female (62.4%) and had moderate-to-severe asthma (63.3%), with 57.1 and 42.9% of patients treated in specialist and primary care, respectively. Asthma was partly controlled/uncontrolled in 66.2% of patients, with 57.9% experiencing ≥1 severe exacerbation in the previous 12 months. Overall, 46.5% of patients were prescribed ≥3 SABA canisters in the preceding 12 months (over-prescription); 26.2% were prescribed ≥10 canisters. SABAs were purchased over-the-counter by 32.6% of patients, of whom 79.3% had received SABA prescriptions; 71.9% and 40.1% for ≥3 and ≥10 canisters, respectively. Higher SABA prescriptions (vs. 1–2 canisters) were associated with increased incidence rate of severe exacerbations and lower odds of having at least partly controlled asthma (except 3–5 canisters). Findings from this African cohort of the SABINA III study indicate that SABA over-prescription and SABA over-the-counter purchase are common and associated with poor asthma-related outcomes. This highlights the need for healthcare providers/policymakers to align clinical practices with the latest treatment recommendations.
Two Images: Cressfield House Ecclefechan, and Bunbeg, County Donegal
Creators: name: (:Unav)
Publisher: name: Columbia University
Year: 2019
Subjects: Dwellings
Cities and towns
Harbors

description: two images: "Cressfield House Ecclefechan" [closely resembling the front elevation of Craigenputtoch]; and Bunbeg, County Donegal [a published photoreproduction]
Additional file 1 of Expert consensus on the management of systemic sclerosis-associated interstitial lung disease
Creators: name: Rahaghi, Franck F.
name: Hsu, Vivien M.
name: Kaner, Robert J.
name: Mayes, Maureen D.
name: Rosas, Ivan O.
name: Saggar, Rajan
name: Steen, Virginia D.
name: Strek, Mary E.
name: Bernstein, Elana J.
name: Bhatt, Nitin
name: Castelino, Flavia V.
name: Chung, Lorinda
name: Domsic, Robyn T.
name: Flaherty, Kevin R.
name: Gupta, Nishant
name: Kahaleh, Bashar
name: Martinez, Fernando J.
name: Morrow, Lee E.
name: Moua, Teng
name: Patel, Nina
name: Shlobin, Oksana A.
name: Southern, Brian D.
name: Volkmann, Elizabeth R.
name: Khanna, Dinesh
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Hematology

description: Additional file 1. Table S1. SSc-ILD Delphi Questionnaire 3 results. Table S2. SSc-ILD Delphi Supplemental Questionnaire 2 results
title: Καινοτομία, έρευνα και ανάπτυξη στις ευρωπαϊκές επιχειρήσεις
Creators: name: Παυλου Αντωνιος
Publisher: name: Technical University of Crete
Year: 2015

description: Στις μέρες μας οι έννοιες της έρευνας και ανάπτυξης και της καινοτομίας, γίνονται όλο και πιο σημαντικές για τις επιχειρήσεις. Αυτό συμβαίνει διότι μέσω των δραστηριοτήτων που αφορούν την Ε&Α ανακαλύπτονται καινούργιες τεχνολογίες, οι οποίες βοηθούν τις επιχειρήσεις να δημιουργήσουν νέα προϊόντα και υπηρεσίες και κατ’ επέκτασή τις βοηθούν στην ανάπτυξη και την σωστή λειτουργία τους. Επίσης, μέσω των δραστηριοτήτων αυτών τους δίνεται η δυνατότητα να  γίνουν ανταγωνιστικές στον κλάδο τους, καθώς και να εδραιώσουν την θέση τους σε ένα περιβάλλον που μεταβάλλεται συνεχώς.
Στην παρούσα εργασία εξετάζεται η επίδραση που έχουν δείκτες  χρηματοοικονομικών στοιχείων των επιχειρήσεων στην μεταβολή των πωλήσεων και την απόδοση του ενεργητικού των επιχειρήσεων.
Στην ανάλυση αυτή χρησιμοποιήθηκε ένα δείγμα 718 επιχειρήσεων που δραστηριοποιούνται σε χώρες της Ευρωπαϊκής Ένωσης, ενώ το χρονικό διάστημα που αντιστοιχούν τα στοιχεία του δείγματος είναι από το 2005 έως το 2013. Για την ανάλυση χρησιμοποιήθηκε το μοντέλο τυχαίων επιδράσεων μέσω του λογισμικού Stata 12.0.
Στο πρώτο μέρος της εργασίας παρουσιάζονται οι έννοιες της Ε&Α και της καινοτομίας  και στο δεύτερο μέρος γίνεται μια ανασκόπηση της βιβλιογραφίας που αφορά άλλες εργασίες που έχουν πραγματοποιηθεί και αφορούν την Ε&Α και καινοτομία. Στο τρίτο μέρος παρουσιάζεται αναλυτικά το μοντέλο που χρησιμοποιήθηκε, κάποια στατιστικά στοιχεία του δείγματος καθώς και των μεταβλητών που χρησιμοποιήθηκαν και τα αποτελέσματα που εξήχθησαν. Τέλος, στο τέταρτο μέρος παρουσιάζονται τα συμπεράσματα που προέκυψαν καθώς και προτάσεις για περαιτέρω έρευνα.
Hamburger Foto-Flut. Zwischen Aufklärung, Information und Augenwischerei
Creators: name: Weinke, Wilfried
Publisher: name: AKMB-news: Informationen zu Kunst, Museum und Bibliothek
Year: 2017

description: -
description: AKMB-news: Informationen zu Kunst, Museum und Bibliothek, Bd. 22, Nr. 1 (2016): AKMB-news
Measurement of hard double-parton interactions in W->lv+ 2 jet events at sqrt(s)=7 TeV with the ATLAS detector
Creators: name: ATLAS Collaboration
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The production of W bosons in association with two jets in proton-proton collisions at a centre-of-mass energy of sqrt(s)=7 TeV has been analysed for the presence of double-parton interactions using data corresponding to an integrated luminosity of 36/pb, collected with the ATLAS detector at the LHC. The fraction of events arising from double-parton interactions, fDP(D) has been measured through the momentum balance between the two jets and amounts to fDP(D) = 0.08 +- 0.01 (stat.) +- 0.02 (sys) for jets with transverse momentum PT > 20 GeV and rapidity |y|<2.8. This corresponds to a measurement of the effective area parameter for hard double-parton interactions of σ_eff = 15 +- 3 (stat.) +5 -3 (sys.) mb.
description: 23 pages plus author list (45 pages total), 10 figures, 2 tables, submitted to NJP. All figures including auxiliary figures are available at http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2011-29/ -Note that v2 differs from v1 only in that the author list was updated-
title: Development of an industrial production line simulation for crystalline silicon photovoltaic panel recycling
title: Ανάπτυξη βιομηχανικής γραμμής παραγωγής ανακύκλωσης φωτοβολταϊκών πινάκων κρυσταλλικού πυριτίου
Creators: name: Ρεντουμης Μελετιος
Publisher: name: Technical University of Crete
Year: 2015

description: Η παραγωγή ενέργειας από φωτοβολταϊκές (φ/β) κυψελίδες είναι μια καθιερωμένη και πολλά υποσχόμενη τεχνολογία που εκμεταλλεύεται στο έπακρο την ηλιακή ενέργεια, η οποία είναι ανανεώσιμη. Παρόλο που έχουν παρουσιαστεί πολυάριθμες μέθοδοι ανά την υφήλιο σχετικά με την ανακύκλωση φ/β πινάκων, η Ελλάδα δεν έχει λάβει κάποια αξιόλογη δράση έως σήμερα. Σε παγκόσμια κλίμακα, το μεγαλύτερο μερίδιο της αγοράς (≈90%) βασίζεται στη χρήση κρυσταλλικού πυριτίου ως ημιαγωγό για τις φ/β κυψελίδες. Επιπλέον, σύμφωνα με εκτιμήσεις αναμένεται πως η συνολική ποσότητα φ/β αποβλήτων στην Ευρώπη θα αγγίξει τους 3.500.000 τόνους μέχρι το 2040, ενώ στην Ελλάδα αναμένονται 264.000 τόνοι μέχρι το 2038. Σαν αποτέλεσμα, κρίνεται σκόπιμη η παρουσίαση μίας ενοποιημένης μεθόδου διαχείρισης φ/β πινάκων όταν εκείνοι φτάνουν το τέλος της χρήσιμης ζωής τους με στόχο την επιτυχή ανάκτηση υλικών όπως: πυρίτιο, αλουμίνιο, άργυρο και γυαλί. Ο στόχος της παρούσης μεταπτυχιακής διατριβής είναι η προσομοίωση μιας μεθόδου ανακύκλωσης φ/β πινάκων κρυσταλλικού πυριτίου, εφαρμόσιμη σε βιομηχανικό επίπεδο, με χρήση της πλατφόρμας σχεδίασης CATIA. Ο σχεδιασμός της διαδικασίας ανακύκλωσης πραγματοποιήθηκε παραμετρικά, με στόχο τη δυνατότητα εύκολης προσαρμογής της χωροθέτησης και διαστασιολόγησης κάθε μηχανήματος και κατ’ επέκταση του πεδίου ανακύκλωσης στο σύνολό του.
description: Power generation from photovoltaic (PV) cells is a well-established and promising technology that takes full advantage of solar energy, which is a renewable energy source. Although numerous methods of PV recycling have been proposed worldwide, Greece has not taken any serious corresponding action until now. In global scale, the largest market share (≈90%) is based on c-Si as a semiconductor for the PV cells. Moreover, estimations expect that the overall quantity of PV waste in Europe will reach 3.500.000 tones until 2040 while in Greece, until 2038 the amount will be in the range of 264.000 tones. As a result, it is essential to propose a unified management of PV end-of-life (EOL) process, in order to achieve a successful recovery of materials such as silicon, aluminum, silver and glass. The scope of this dissertation is the simulation of an integrated c-Si PV recycling process, applicable to the industrial level, with the use of CATIA software. The design of this recycling process is parametric, in order to allow the location and sizing configuration of each machine and installation type that can be used.
Large Primordial Fluctuations in Gravitational Waves from Phase Transitions
Creators: name: Bodas, Arushi
name: Sundrum, Raman
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: It is well-known that first order phase transitions in the early universe can be a powerful source of observable stochastic gravitational wave backgrounds. Any such gravitational wave background must exhibit large-scale anisotropies at least as large as those seen in the CMB $\sim 10^{-5}$, providing a valuable new window onto the (inflationary) origins of primordial fluctuations. While significantly larger fractional anisotropies are possible (for example, in multi-field inflation) and would be easier to interpret, it has been argued that these can only be consistent with CMB bounds if the gravitational wave signal is correspondingly smaller. In this paper, we show that this argument, which relies on assuming radiation dominance of the very early universe, can be evaded if there is an era of early matter dominance of a certain robust type. This allows large gravitational wave anisotropies to be consistent with observable signals at proposed future gravitational wave detectors. Constraints from the CMB on large scales, as well as primordial black hole and mini-cluster formation on small scales, and secondary scalar-induced gravitational waves are all taken into account.
description: 21 pages, 6 figures
Casimir Energy and Entropy between perfect metal Spheres
Creators: name: Rodriguez-Lopez, Pablo
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Physics (quant-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We calculate the Casimir energy and entropy for two perfect metal spheres in the large and short separation limit. We obtain nonmonotonic behavior of the Helmholtz free energy with separation and temperature, leading to parameter ranges with negative entropy, and also nonmonotonic behavior of the entropy with temperature and with the separation between the spheres. The appearance of this anomalous behavior of the entropy is discussed as well as its thermodynamic consequences.
description: 10 pages and 8 figures. Accepted for publication in the Proceedings of the tenth conference on Quantum Field Theory under the influence of external conditions - QFEXT'11
title: Πρόβλεψη υδατικών αναγκών στο Λουτράκι Κορινθίας
Creators: name: Ζογκας Δημητριος
Publisher: name: Technical University of Crete
Year: 2015

description: Η παρούσα διπλωματική εργασία ασχολείται με την πρόβλεψη των υδατικών αναγκών της πόλης του Λουτρακίου. Λαμβάνοντας υπόψη τις ιδιαιτερότητες του Λουτρακίου, του υδροφόρου ορίζοντα του νερού Λουτρακίου  και του δικτύου ύδρευσης καθώς και τα αποτελέσματα που προέκυψαν με βάση τις αναλύσεις και τις προβλέψεις, κατέληξα σε μια σειρά προτάσεων, άμεσα υλοποιήσιμων. Ενέργειες οι οποίες μπορούν να δώσουν συγκεκριμένες λύσεις για την εξοικονόμηση υδατικών πόρων αλλά και την εύρεση νέων.
Η διπλωματική εργασία είναι διαρθρωμένη σε εφτά κεφάλαια.
Το πρώτο κεφάλαιο αναφέρεται στην παγκόσμια χρήση του νερού και στο πως κατανέμεται αυτή σε κάθε περιοχή του πλανήτη. Η παγκόσμια έλλειψη νερού και κατ’ επέκταση η λειψυδρία, η οποία μαστίζει πολλούς συνανθρώπους μας, κατέχει ένα σημαντικό κομμάτι στο πρώτο κεφάλαιο, καθώς όλα συνηγορούν στο ότι θα είναι το νέο μεγάλο ζήτημα που θα καλεστούμε να αντιμετωπίσουμε τα επόμενα χρόνια. Στην συνέχεια αναλύεται η κατάσταση που υπάρχει στον Ελλαδικό χώρο και το πώς κατανέμονται οι χρήσεις νερού. Τέλος αναφέρονται οι παράγοντες που ευθύνονται για την έλλειψη υδατικών πόρων σε αρκετές περιοχές της Ελλάδας.
Στο δεύτερο κεφάλαιο υπάρχουν πληροφορίες για τον Δήμο Λουτρακίου – Περαχώρας – Αγ. Θεοδώρων και ειδικότερα για την πόλη του Λουτρακίου καθώς και για τον υδροφόρο ορίζοντα μεταλλικού νερού Λουτρακίου (γενικά στοιχεία, γεωγραφική θέση της πόλης, πληθυσμιακή κατανομή, πολεοδόμηση περιοχής Λουτρακίου, γεωμορφολογικές παρατηρήσεις, υφιστάμενη κατάσταση υδροφόρου ορίζοντα, χημικές αναλύσεις νερού Λουτρακίου).
Στο τρίτο κεφάλαιο γίνεται μια ανάλυση των χρήσεων νερού ανά καταναλωτή για την περίοδο 2003-2014, σύμφωνα με τα στοιχεία που μου χορηγήθηκαν από την Δημοτική Επιχείρηση Ύδρευσης – Αποχέτευσης (ΔΕΥΑΛ-ΑγΘ).
Στο τέταρτο κεφάλαιο αναλύεται η μεθοδολογία με βάση την όποια υπολογίστηκε ο πληθυσμός του Λουτρακίου για το έτος 2040.
Στο πέμπτο κεφάλαιο παρουσιάζεται η εκτίμηση των συνολικών υδατικών αναγκών του Λουτρακίου για το έτος 2040.
Στο έκτο κεφάλαιο περιλαμβάνονται οι προτάσεις για την εύρεση νέων υδατικών πόρων αλλά και την εξοικονόμηση των ήδη υπαρχόντων (έλεγχος διαρροών,  αντικατάσταση υδροδικτύου όπου κριθεί απαραίτητο, χρήση ανακυκλωμένου νερού από τον βιολογικό καθαρισμό μέσω τριτοβάθμιας επεξεργασίας, κατασκευή υδροδικτύων άρδευσης για την επέκταση σχεδίου πόλης Λουτρακίου έτους 1979 – περιοχή «Λειβαδάκι). Οι συγκεκριμένες προτάσεις δεν αφορούν μόνο το έτος 2040. Μπορούν να δώσουν σημαντικές λύσεις και στο σημερινό πρόβλημα που αντιμετωπίζει το Λουτράκι με την διαφαινόμενη υπεράντληση του υδροφόρου ορίζοντα και την επερχόμενη έλλειψη πόρων νερού.
Τέλος, στο έβδομο κεφάλαιο παραθέτονται τα συμπεράσματα που προκύπτουν από την μελέτη και την πρόβλεψη των υδατικών αναγκών του Λουτρακίου.
Calibration strategy of the PROSPECT-II detector with external and intrinsic sources
Creators: name: Andriamirado, M.
name: Balantekin, A. B.
name: Bass, C. D.
name: Bergeron, D. E.
name: Bernard, E. P.
name: Bowden, N. S.
name: Bryan, C. D.
name: Carr, R.
name: Classen, T.
name: Conant, A. J.
name: Delgado, A.
name: Diwan, M. V.
name: Dolinski, M. J.
name: Erickson, A.
name: Foust, B. T.
name: Gaison, J. K.
name: Galindo-Uribarri, A.
name: Gilbert, C. E.
name: Gokhale, S.
name: Grant, C.
name: Hans, S.
name: Hansell, A. B.
name: Heeger, K. M.
name: Heffron, B.
name: Jaffe, D. E.
name: Jayakumar, S.
name: Ji, X.
name: Jones, D. C.
name: Koblanski, J.
name: Kunkle, P.
name: Lane, C. E.
name: Langford, T. J.
name: LaRosa, J.
name: Littlejohn, B. R.
name: Lu, X.
name: Maricic, J.
name: Mendenhall, M. P.
name: Meyer, A. M.
name: Milincic, R.
name: Mueller, P. E.
name: Mumm, H. P.
name: Napolitano, J.
name: Neilson, R.
name: Nikkel, J. A.
name: Nour, S.
name: Palomino, J. L.
name: Pushin, D. A.
name: Qian, X.
name: Roca, C.
name: Rosero, R.
name: Searles, M.
name: Surukuchi, P. T.
name: Sutanto, F.
name: Tyra, M. A.
name: Venegas-Vargas, D.
name: Weatherly, P. B.
name: Wilhelmi, J.
name: Woolverton, A.
name: Yeh, M.
name: Zhang, C.
name: Zhang, X.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: This paper presents an energy calibration scheme for an upgraded reactor antineutrino detector for the Precision Reactor Oscillation and Spectrum Experiment (PROSPECT). The PROSPECT collaboration is preparing an upgraded detector, PROSPECT-II (P-II), to advance capabilities for the investigation of fundamental neutrino physics, fission processes and associated reactor neutrino flux, and nuclear security applications. P-II will expand the statistical power of the original PROSPECT (P-I) dataset by at least an order of magnitude. The new design builds upon previous P-I design and focuses on improving the detector robustness and long-term stability to enable multi-year operation at one or more sites. The new design optimizes the fiducial volume by elimination of dead space previously occupied by internal calibration channels, which in turn necessitates the external deployment. In this paper, we describe a calibration strategy for P-II. The expected performance of externally deployed calibration sources is evaluated using P-I data and a well-benchmarked simulation package by varying detector segmentation configurations in the analysis. The proposed external calibration scheme delivers a compatible energy scale model and achieves comparable performance with the inclusion of an additional AmBe neutron source, in comparison to the previous internal arrangement. Most importantly, the estimated uncertainty contribution from the external energy scale calibration model meets the precision requirements of the P-II experiment.
description: 19 pages, 10 figures
Variation in costs due to virtual switching from free- to fixed-triple LABA/LAMA/ICS combinations among COPD patients: an analysis using a primary care database
Creators: name: Lapi, Francesco
name: Marconi, Ettore
name: Lombardo, Francesco Paolo
name: Micheletto, Claudio
name: Cricelli, Claudio
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Chronic obstructive pulmonary disease (COPD) is a condition with a relevant clinical and economic burden. Only 10% to 40% of COPD patients reporting a regular use of respiratory medications, including those who suffered from severe disease being prescribed with triple combination therapy, nominally long-acting beta agonist (LABA), long-acting muscarinic antagonist (LAMA) and inhaled corticosteroid (ICS). The recent market launch of fixed-triple LABA/LAMA/ICS therapy might contribute to improve medications adherence and costs containment, given the use of a single instead of two or three inhalers. Few data are available on costs due to triple therapy prescribed for COPD. In specific, there are no studies providing data on the potential costs saving whether COPD patients exposed to free-triple combination therapy were switched to fixed-triple combination. In this respect, we simulated some scenarios of virtual switching and calculated the related cost savings.
Noncommutative Quantum Gravity
Creators: name: Faizal, Mir
Publisher: name: arXiv
Year: 2013
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We discuss the BRST and anti-BRST symmetries for perturbative quantum gravity in noncommutative spacetime. In this noncommutative perturbative quantum gravity the sum of the classical Lagrangian density with a gauge fixing term and a ghost term is shown to be invariant the noncommutative BRST and the noncommutative anti-BRST transformations. We analyse the gauge fixing term and the ghost term in both linear as well as non-linear gauges. We also discuss the unitarity evolution of the theory and analyse the violation of unitarity of by introduction of a bare mass term in the noncommutative BRST and the noncommutative anti-BRST transformations.
description: 11 pages, 0 figures, accepted for publication in Mod. Phys. Lett. A
Impact of apixaban treatment discontinuation on the risk of hospitalization among patients with nonvalvular atrial fibrillation and COVID-19
Creators: name: Deitelzweig, Steven
name: Zhu, Julia
name: Jiang, Jenny
name: Luo, Xuemei
name: Keshishian, Allison
name: Ferri, Mauricio
name: Rosenblatt, Lisa
name: Schuler, Patricia
name: Gutierrez, Cynthia
name: Dhamane, Amol D.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: Hematology

description: This study evaluated the risk of hospitalization among nonvalvular atrial fibrillation (NVAF) patients with an outpatient COVID-19 diagnosis who discontinued vs continued apixaban treatment. Adult patients with NVAF with an apixaban prescription prior to an outpatient COVID-19 diagnosis were identified from Optum Clinformatics claims database (1 April 2020–31 March 2021). Continuers were those who continued apixaban as of the index date (date of initial outpatient COVID-19 diagnosis) and discontinuers were those who had the last day of apixaban supply on or before index. Patients were followed from COVID-19 diagnosis to change of continuation/discontinuation status, switch, death, end of continuous coverage or study end, whichever occurred first. Inverse probability treatment weighting (IPTW) was performed to balance cohorts. Cox proportional hazard models were used to compare the risk of all-cause hospitalization and hospitalization for ischemic stroke (IS), venous thromboembolism (VTE), myocardial infarction (MI), bleeding and mortality. A total of 7869 apixaban patients with COVID-19 were included: 6676 continuers (84.8%) and 1193 discontinuers (15.2%). Compared with continuers, discontinuers had a higher risk of all-cause hospitalization (hazard ratio [HR]: 1.23; 95% confidence interval [CI]: 1.08–1.40), IS (HR: 2.00; 95% CI: 1.03–3.87), VTE (HR: 2.37; 95% CI: 1.06–5.27) and mortality (HR: 2.28; 95% CI: 1.85–2.80). There were no significant differences in the risk of MI (HR: 1.01; 95% CI: 0.54–1.90) or bleeding-related hospitalization (HR: 1.13; 95% CI: 0.73–1.76). NVAF patients with COVID-19 who discontinued apixaban had a higher risk of hospitalization and thrombotic events vs those who continued apixaban, with no significant difference in bleeding-related hospitalization.
Research ethics committees and post-approval activities: a qualitative study on the perspectives of European research ethics committee representatives
Creators: name: Cox, Shereen
name: Solbakk, Jan Helge
name: Bernabe, Rosemarie D. L. C.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Evolutionary Biology
subject: Science Policy
subject: Cancer

description: To explore the views of Research Ethics Committee (REC) representatives in the European Union (EU) on what the status quo is in terms of RECs’ activities after the approval of trial protocols for clinical studies. This is a qualitative study. The participants in this study are members or representatives of a research ethics committee from the member countries of the European Network of Research Ethics Committees (EUREC) and the United Kingdom. Thematic analysis was the method to assess interview transcripts. Interviews of REC representatives from 19 countries across Europe reveals that REC post-approval activities are predominantly limited to review and approval of protocol amendments. The majority of the RECs do not have mandatory continuing reviews or receipt of notifications of adverse events or protocol violations. In fact, most post-approval activities are the remit of the regulatory authorities. The interviewed members were also of the opinion that RECs in the EU do not have the legislative support, the organizational structure, the expert staff nor time to do active post approval follow-up. Post-approval follow-up activities for clinical studies by RECs is a valuable resource and means for early detection and resolution of protocol deviations and violations. However, a majority of RECs within Europe do not have active post-approval follow-up of approved protocols. The interviews revealed that resource challenges such as time, personnel, and organizational structure contribute to the lack of follow-up by RECs. Some RECs in the represented countries do not identify post-approval follow-up as part of their mandate but instead place emphasis on the culture of trust between the RECs and researchers. Current EU Regulations do not directly address the role of the REC after the approval of clinical trials.
Additional file 1 of Composition and variability of core phyllosphere fungal mycobiota on field-grown broccoli
Creators: name: Kim, Min-Soo
name: Park, Eun-Jin
Publisher: name: figshare
Year: 2023
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional file 1: Fig. S1. The images of the farms, broccoli plants and flower heads are provided (Kim et al., 2018). Fig. S2. (A) The statistics of pairwise comparison among the fungal communities of the farming regions on the basis of Bray-Curtis dissimilarity and Jaccard distance. Statistical significance was evaluated with Bray-Curtis dissimilarity using PERMANOVA (B) Comparison of relative abundance of core and unique ASVs in the farming regions. Statistical significance was evaluated using two-tailed Mann-Whitney U test. (C) The relative abundance of three discriminant ASVs for regional variation were shown. Fig. S3. Community-level associations between Jaccard distance-based db-RDA plots constrained to farming region and six selected agrometeorological factors were performed using Procrustes analysis. The db-RDA plots constrained to farming region were generated by excluding either core ASVs (A) or unique ASVs (B). Fig. S4. (A) Immature and mature fungal communities were compared by using Principal coordinates Analysis based on Jaccard distance. (B) Effect size scores of linear discriminant analysis calculated for differences in fungal ASVs abundance between mature and immature samples (logarithmic LDA score >3.0). Fig. S5. The clustering of fungal communities of field-grown broccoli. (A) The optimal number of clusters were defined based on Calinski-Harabasz index (lower right panel), and fungal communities were clustered into two groups. Two ASVs that had the strongest correlations with the first axis of PCoA were shown (r > 0.5, P < 0.01). (B) The abundant ASVs of cluster 1 (upper panel) and 2 (lower panel) types are shown using a rank abundance plot. Box and whisker plots are shown to min and max. (C) The relative abundances of Purpureocillium and Filobasidium ASVs were correlated with the first axis of unsupervised PCoA plot for Bray-Curtis dissimilarity. Statistical significance was determined by Pearson correlation. Total number of viable fungi (D) and diversity indices (E) of fungal communities of the two clusters were compared. All data are mean ± SD. Statistical significance was determined by two-tailed Mann-Whitney U test. Fig. S6. Total number of viable fungi and bacteria (A), and fungal diversity indices (B) were compared between Filobasidium and Purpureocillium types. All data are mean ± SD. Statistical significance was determined by two-tailed Mann-Whitney U test. (C) The abundance of the Purpureocillium ASV in the communities of four farming regions. Dots colored in red, orange, green, and purple indicate samples originated from the same farm.
A solution to the problems of cusps and rotation curves in dark matter halos in the cosmological standard model
Creators: name: Doroshkevich, A. G.
name: Lukash, V. N.
name: Mikheeva, E. V.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We discuss various aspects of the inner structure formation in virialized dark matter (DM) halos that form as primordial density inhomogeneities evolve in the cosmological standard model. The main focus is on the study of central cusps/cores and of the profiles of DM halo rotation curves, problems that reveal disagreements among the theory, numerical simulations, and observations. A method that was developed by the authors to describe equilibrium DM systems is presented, which allows investigating these complex nonlinear structures analytically and relating density distribution profiles within a halo both to the parameters of the initial small-scale inhomogeneity field and to the nonlinear relaxation characteristics of gravitationally compressed matter. It is shown that cosmological random motions of matter `heat up' the DM particles in collapsing halos, suppressing cusp-like density profiles within developing halos, facilitating the formation of DM cores in galaxies, and providing an explanation for the difference between observed and simulated galactic rotation curves. The analytic conclusions obtained within this approach can be confirmed by the N-body model simulation once improved spatial resolution is achieved for central halo regions.
description: 44 pages, 16 figures, 1 table
Oxford Latin Dictionary. Hrsg. von Peter G.W. Glare. Second Edition (2 Bde.)
Creators: name: Habermehl, Peter
Publisher: name: Forum Classicum
Year: 2017

description: Rezension zu: Oxford Latin Dictionary. Hrsg. von Peter G.W. Glare. Second Edition (2 Bde.). Oxford: Oxford University Press 2012. 2398 S. (ISBN 0- 19-958031-6).
description: Forum Classicum, Nr. 1 (2013): Forum Classicum
String tension from gauge invariant Magnetic Monopoles
Creators: name: Cundy, Nigel
name: Lee, Weonjong
name: Leem, Jaehoon
name: Cho, Y. M.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We investigate the relationship between colour confinement and the monopoles derived from the Cho-Duan-Ge decomposition. These monopoles, unlike Dirac and 't Hooft monopoles, do not require a singular gauge field and are defined for any choice of gauge (and are not just restricted to, for example, the maximum Abelian gauge). The Abelian decomposition is defined in terms of a colour field $n$; the principle novelty of our study is that we have used a unique definition of this field in terms of the eigenvectors of the Wilson Loop. This allows us to investigate the relationship between the gauge invariant monopoles and confinement both analytically and numerically, as well as retaining the maximal possible symmetry within the colour field so that it is able to see all the monopoles in an SU($N_C$) calculation. We describe how the Abelian decomposition is related to the Wilson Loop, so that the string tension may be calculated from the field strength related to the decomposed (or restricted) Abelian field. We discuss the structures in the colour field which may cause an area law in the Wilson Loop, which turn out to be magnetic monopoles. If these monopoles are present, they will lead to an area law scaling of the Wilson Loop and thus be at least partially responsible for confinement. We search for these monopoles in quenched lattice QCD. We show that the string tension is dominated by peaks in the restricted field strength, at least some of which are located close to structures in the colour field consistent with with theoretical expectations for the monopoles. We show that the string tension extracted from the monopole contribution to the restricted field is close to that of the entire original field; again suggesting that confinement can at least partially be explained in terms of these monopoles.
description: Lattice 2012 (Chiral Symmetry), 7 pages
A route from maximal chaoticity to integrability
Creators: name: Ma, Chen
name: Tian, Chushun
Publisher: name: arXiv
Year: 2022
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Theory (hep-th)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: We study the chaos exponent of some variants of the Sachdev-Ye-Kitaev (SYK) model, namely, the $\Ns=1$ supersymmetry (SUSY)-SYK model and its sibling, the $(N|M)$-SYK model which is not supersymmetric in general, for arbitrary interaction strength. We find that for large $q$ the chaos exponent of these variants, as well as the SYK and the $\Ns=2$ SUSY-SYK model, all follow a single-parameter scaling law. By quantitative arguments we further make a conjecture, i.e. that the found scaling law might hold for general one-dimensional (1D) SYK-like models with large $q$. This points out a universal route from maximal chaos towards completely regular or integrable motion in the SYK model and its 1D variants.
description: 23 pages, 5 figures
Evaluation of knowledge and practices about administration and regulations of high alert medications among hospital pharmacists in Pakistan: findings and implications
Creators: name: Salman, Muhammad
name: Mustafa, Zia Ul
name: Shehzadi, Naureen
name: Mallhi, Tauqeer Hussain
name: Asif, Noman
name: Khan, Yusra Habib
name: Khan, Tahir Mehmood
name: Hussain, Khalid
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Cell Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: A death of a nine months old child in Pakistan following the rapid administration of potassium chloride raised serious concerns on the awareness of appropriate use of high alert medications (HAMs) among healthcare professionals (HCPs). This study aimed to ascertain HAMs-related knowledge among hospital pharmacists in Pakistan. A cross-sectional study using exponential non-discriminative snowball sampling was conducted among hospital pharmacists in healthcare settings in Punjab, Pakistan. A validated study tool was used to determine knowledge on administration, regulation, and practices related to the HAMs. Barriers to conducting HAMs training in the hospitals were assessed from an open-ended question. All quantitative data were analyzed using SPSS 22.0 while the content analysis was performed on the qualitative data. A total of 202 hospital pharmacists were included in the study. The mean knowledge score for HAMs administration and regulation were 5.86 ± 1.89 (95% CI 5.60–6.12) and 7.25 ± 1.70 (95% CI 7.02–7.49), respectively. Approximately half of the respondents (49.5%) achieved scores ≥ 70%, demonstrating sufficient knowledge of HAMs. In the multivariable-adjusted model, increasing age and work experience were found to be the positive predictors of good HAMs knowledge. The mean practice score was 36.42 ± 1.97 (95% CI 34.05–38.77), with 62.4% of pharmacists following good HAMs-related practices. We identified several barriers to conducting HAMs training through qualitative analysis. These barriers included lack of knowledge, poor attitude and behavior of medical and paramedical staff, false beliefs, lack of active support by hospital administration, lack of cooperation between HCPs, lack of opportunities, heavy workload, insufficient human resources, financial constraints, and lack of motivation. A significant proportion of the hospital pharmacists had unsatisfactory knowledge and practices of HAMs. These findings underscore that training on HAMs should be conducted periodically as a part of hospital-based pharmacy education to maximize drug safety.
Additional file 1 of Helmet continuous positive airway pressure versus high-flow nasal cannula in COVID-19: a pragmatic randomised clinical trial (COVID HELMET)
Creators: name: Tverring, Jonas
name: Åkesson, Anna
name: Nielsen, Niklas
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Additional file 1.
On holographic thermalization and gravitational collapse of tachyonic scalar fields
Creators: name: Wu, Bin
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: In this paper we study the thermalization of a spatially homogeneous system in a strongly coupled CFT. The non-equilibrium initial state is created by switching on a relevant perturbation in the CFT vacuum during Delta t >= t >= -Delta t. Via AdS/CFT, the thermalization process corresponds to the gravitational collapse of a tachyonic scalar field (m^2 = -3) in the Poincare patch of AdS_5. In the limit Delta t < 0.02/T, the thermalization time t_T is found to be quantitatively the same as that of a non-equilibrium state created by a marginal perturbation discussed in Ref. [5]. In the case Delta t >= 1/T, we also obtain double-collapse solutions but with a non-equilibrium intermediate state at t = 0. In all the cases our results show that the system thermalizes in a typical time t_T ~ O(1)/T. Besides, a conserved energy-moment current in the bulk is found, which helps understand the qualitative difference of the collapse process in the Poincare patch from that in global AdS[9, 10].
description: 24 pages, 13 figures, minor modifications, references added, final version to appear in JHEP
Using Off-Resonance Laser Modulation for Beam Energy Spread Cooling in Generation of Short-Wavelength Radiation
Creators: name: Deng, Haixiao
Publisher: name: arXiv
Year: 2013
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Various seeding configurations have being proposed for frequency up-conversion of the electron beam density distribution, in which the energy spread, may however hinder the harmonic generation efficiency. In this Letter, a method for cooling the electron beam energy spread by off-resonance seed laser modulation is described, using a transversely dispersed beam and a modulator undulator with proper transverse gradient. With this novel mechanism, it is shown that the frequency up-conversion efficiency can be significantly enhanced. We present theoretical analysis and numerical simulations for seeded soft x-ray free electron laser and storage ring based coherent harmonic generation in extreme ultraviolet spectral region.
description: 6 pages, 5 figures
Probing de Sitter from the horizon
Creators: name: Mirbabayi, Mehrdad
name: Riccardi, Flavio
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In a QFT on de Sitter background, one can study correlators between fields pushed to the future and past horizons of a comoving observer. This is a neat probe of the physics in the observer's causal diamond (known as the static patch). We use this observable to give a generalization of the quasinormal spectrum in interacting theories, and to connect it to the spectral density that appears in the Källén-Lehmann expansion of dS correlators. We also introduce a finite-temperature effective field theory consisting of free bulk fields coupled to a boundary. In matching it to the low frequency expansion of correlators, we find positivity constraints on the EFT parameters following from unitarity.
description: 24 pages, 3 figures
ESM_Character_matrix from New fossils of Jurassic ophiurid brittle stars (Ophiuroidea; Ophiurida) provide evidence for early clade evolution in the deep sea
Creators: name: Thuy, Ben
name: Numberger-Thuy, Lea D.
name: Pineda-Einríquez, Tania
Publisher: name: The Royal Society
Year: 2021
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences
subject: 60301 Animal Systematics and Taxonomy
subject: 60310 Plant Systematics and Taxonomy

description: Matrix of the character scores for all the taxa included in the phylogenetic analyses.
Antibody binding reports spatial heterogeneities in cell membrane organization
Creators: name: Arnold, Daniel P.
name: Xu, Yaxin
name: Takatori, Sho C.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: The spatial organization of cell membrane glycoproteins and glycolipids is critical for mediating the binding of ligands, receptors, and macromolecules on the plasma membrane. However, we currently do not have the methods to quantify the spatial heterogeneities of macromolecular crowding on live cell surfaces. In this work, we combine experiment and simulation to report crowding heterogeneities on reconstituted membranes and live cell membranes with nanometer spatial resolution. By quantifying the effective binding affinity of IgG monoclonal antibodies to engineered antigen sensors, we discovered sharp gradients in crowding within a few nanometers of the crowded membrane surface. Our measurements on human cancer cells support the hypothesis that raft-like membrane domains exclude bulky membrane proteins and glycoproteins. Our facile and high-throughput method to quantify spatial crowding heterogeneities on live cell membranes may facilitate monoclonal antibody design and provide a mechanistic understanding of plasma membrane biophysical organization.
description: 31 pages, 4 figures. See Supporting Information in Ancillary files (1 appendix, 3 movies)
Additional file 2 of Composition and variability of core phyllosphere fungal mycobiota on field-grown broccoli
Creators: name: Kim, Min-Soo
name: Park, Eun-Jin
Publisher: name: figshare
Year: 2023
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional file 2: Table S1. The information of sampling locations. Table S2. Sequence processing.
"Pull moves" for rectangular lattice polymer models are not fully reversible
Creators: name: Györffy, Dániel
name: Závodszky, Péter
name: Szilágyi, András
Publisher: name: arXiv
Year: 2012
Subjects: subject: Biomolecules (q-bio.BM)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: "Pull moves" is a popular move set for lattice polymer model simulations. We show that the proof given for its reversibility earlier is flawed, and some moves are irreversible, which leads to biases in the parameters estimated from the simulations. We show how to make the move set fully reversible.
description: 4 pages, 2 figures. To be published in IEEE/ACM Transactions on Computational Biology and Bioinformatics
[Gymnasium Heft 120,1,2013 / Antike Welt Heft 2/2013 / Welt und Umwelt der Bibel, Heft 68, 2/2013 …]
Creators: name: Rabl, Josef
Publisher: name: Forum Classicum
Year: 2017

description: -
description: Forum Classicum, Nr. 2 (2013): Forum Classicum
title: Πολυκριτήρια ανάλυση και οικονομική αξιολόγηση των Οργανισμών Τοπικής Αυτοδιοίκησης (Ο.Τ.Α.)
Creators: name: Χέλμης Ερμής
Publisher: name: Technical University of Crete
Year: 2011

description: Μη διαθέσιμο