cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Perceptions of Year 9 English teachers in Darwin about the backwash effects of NAPLAN Reading Testing
Creators: name: Borlagdan, Jean
Publisher: name: Charles Darwin University
Year: 2014

description: In recent years the National Assessment Program-Literacy and Numeracy (NAPLAN) has played an increasingly important role in Australian education and there is evidence that it has become a high-stakes measure of achievement. Research suggests that this kind of largescale, high-stakes accountability testing has a profound impact on teaching and learning. This effect is generally referred to as “backwash”. This study focused on the perceptions of Year 9 English teachers in selected schools in Darwin in relation to the backwash effects of NAPLAN Reading testing. Those participating in this study teach a number of students whose NAPLAN achievement in 2008-13 was either just above the National Minimum Standard in Reading or below it. This demonstrates the apparent challenge facing them as they need to cater for older students who have reading difficulties and must undertake the NAPLAN test. A descriptive survey method was used to gather data on how teachers perceived the NAPLAN Reading testing and its effects on (i) their instructional decisions in class and (ii) the learning outcomes of their students. Data showed that although teachers were polarised on whether they felt positively or negatively towards NAPLAN, they generally viewed NAPLAN as a high-stakes test which put extra pressure on them and their students. On the whole teachers had negative perceptions of testing and its effects; most teachers reported that they engaged in test-preparation practices such as “teaching to the test”, thereby distorting and narrowing the curriculum. However, some teachers expressed a contrary view, claiming that the testing has positive effects (beneficial backwash) or no effect (neutral backwash) on their instructional decisions and student learning. As it is unlikely that high-stakes testing and accountability pressures on Australian teachers will be reduced, understanding the phenomenon of backwash and how teachers perceive testing is a useful way of contributing to the debate about the value of national tests such as these.
[M{κ2S,S-S2C-piperazine-C2H4N=C(R)}n] {Co(III), Ni(II), Cu(II) or Zn(II)} complexes bearing pendant Schiff base moieties: spectral characterization, fluorescence, cyclic voltammetric and TGA/DTA study
Creators: name: Verma, Sanjay K.
name: Singh, Vinay K.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Physiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Cell Biology
subject: Microbiology
subject: Physics
subject: Biochemistry
subject: Biophysics

description: A series of neutral mononuclear complexes [M{κ2S,S-S2C-piperazine-C2H4N=C(R)}n] {R = Ph; M = Co(III) 1, Ni(II) 2, Cu(II) 3, Zn(II) 4; R = Naph; M = Co(III) 5, Ni(II) 6, Cu(II) 7, Zn(II) 8; n = 2 for 2–4, 6–8 and n = 3 for 1, 5} bearing pendant Schiff base moieties were synthesized through self-assembly involving N-[phenylmethylidene]-2-piperazin-1-ylethanamine (L1) or N-[naphthylmethylidene]-2-piperazin-1-ylethanamine (L2) with two equivalents each of CS2 and corresponding metal acetates. The complexes 1–8 were characterized by microanalysis, ESI-MS, IR, 1H, 13C NMR, DEPT 135, UV–visible absorption, and emission spectroscopy. Complexes 1, 3, and 8 exhibit fluorescence emissions at 342, 344, and 348 nm upon excitation at 273 (for 1 and 3) and 263 (for 8) with concomitant Stokes shifts of 69, 71, and 85 nm. The spectral and magnetic moment data support octahedral geometry around Co(III) and square planar/tetrahedral geometry around other metal centers. Thermal stabilities of 1–8 have been investigated by thermogravimteric analysis. The cyclic voltammograms clearly suggest that the complexes exhibit electroreduction principally associated with pendant imine moieties except Cu(II) complex 7 which displays quasi-reversible reduction corresponds to the Cu(II)/Cu(I) redox couples, in addition to reversible electroreduction of pendant imine groups associated with the coordinated ligands.
title: LEONARD-11-2_07_25
Creators: name: Morgenstern, Aliyah
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2014
Subjects: subject: Français
subject: fra

description: C'est l'heure du dîner de Léonard. Il regarde la caméra.
description: Conforms to: doi:10.34847/cocoon.49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
description: Conforms to: Format CHAT
title: LEONARD-12-2_11_03
Creators: name: Morgenstern, Aliyah
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2014
Subjects: subject: Français
subject: fra

description: C'est l'heure du dîner de Léonard. Il regarde la caméra.
description: Conforms to: doi:10.34847/cocoon.49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
description: Conforms to: Format CHAT
title: Fortifier un lieu, une ville, un territoire
Publisher: name: Institut Français d'Études Anatoliennes Georges Dumézil
Year: 2010

description: Ce séminaire mensuel s'attachera à présenter un large panel de sites fortifiés bâtis entre le Xe et le XVe siècle en Anatolie et dans les régions voisines. Cette période est marquée entre autre par les dernières splendeures de l'empire byzantin avant sa désagrégation et l'avènement de l'empire ottoman. À travers les exemples présentés (Constantinople, Ani, Diyarbakır,...), les intervenants aborderont des questions liées à l'architecture militaire et, à une échelle plus large, à des notions de géostratégie ou de protection du territoire.   La période qui s'étend du Xe au XVe siècle a été fortement marquée par de nombreux remaniements géopolitiques en Asie Mineure. En effet, des reconquêtes byzantines réalisées par les empereurs macédoniens jusqu'à l'avènement de l'empire ottoman marqué par la prise de Constantinople en 1453, cette partie d
Third Thing: Digital Skills Training at the University of Melbourne
Creators: name: LOVELACE-TOZER, MEIRIAN
name: Shermon, Alexander
Publisher: name: The University of Melbourne
Year: 2024
Subjects: classificationCode: 460909
subject: Information systems philosophy, research methods and theory

description: Do you want to learn to code in Python, R, or MATLAB? Are the prohibitive costs of learning research software like NVivo a barrier to entry? Are you interested in 3D printing and data, but don’t know where to start? Have you thought about using a tool like LaTeX to make it easier to type your thesis or publish an article? Maybe you just want to talk to someone who understands how difficult this whole thing is?The Digital Skills Training team provides online and in-person workshops for a range of tools across the lifespan of your research journey. Our free, accessible, and high-quality research software training is available to all researchers across the University, and helps build communities of practice among scholars. We are part of the Melbourne Data Analytics Platform, a team of research data and academic specialists enabling data-intensive and collaborative research across the University of Melbourne.
Workshop Poster Abstracts - Modeling the Spread and Control of Ebola in W. Africa
Creators: name: Ebola Modeling Workshop At Georgia Tech
Publisher: name: figshare
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Summary: Compendium of poster abstracts presented as part of the workshop: "Modeling the Spread and Control of Ebola in W. Africa" that took place January 22-23, 2015. Workshop title: Modeling the Spread and Control of Ebola in W. Africa Organizers: Prof. Joshua Weitz (Chair, Georgia Institute of Technology), Prof. Rustom Antia (Emory University), Prof. John M. Drake (University of Georgia-Athens), Prof. Jonathan Dushoff (McMaster), Dr. John Glasser (Centers for Disease Control and Prevention), Prof. Pinar Keskinocak (Georgia Institute of Technology), Prof. Lauren Meyers (University of Texas-Austin), Prof. Fredrik Vannberg (Georgia Institute of Technology) Website: bit.ly/ebm_gt Mission: A two day-workshop to: report on and discuss the use of dynamical models to support, interpret and enhance public-health practices to stop the spread of Ebola in West Africa. Location: Historic Academy of Medicine at the Georgia Institute of Technology, Atlanta, GA Dates: January 22-23, 2015
title: Drug-susceptibility and molecular characterization of epidemic and endemic malaria in Kenya
Creators: name: Omar, SA
Publisher: name: London School of Hygiene & Tropical Medicine
Year: 2002

description: Malaria in Kenya continues to pose a great threat to health. Trials with sulfadoxine/ pyrimethamine (SP), currently recommended to replace chloroquine (CQ) in drug-resistant areas, were carried out between 1997 and 1999 in Plasmodium falciparum endemic and epidemic sites. In vitro assays showed that over 50% of isolates were resistant to CQ and SP and sensitive to both quinine and mefloquine. In Busia, an endemic site, efficacy of combination treatment with C Q and SP was compared with SP alone. The combination was more effective in fever resolution. SP and co-trimoxazole (sulfamethoxazole/trimethoprim) were compared in the Oyugis and Tiwi endemic sites and all outcomes were found to be equivalent. Codon changes in dhps and dhfr genes (on chromosomes 8 and 4) conferring in vitro resistance to sulfadoxine and pyrimethamine, predicted SP treatment failures in Mosoriot, an epidemic site, but age-related recovery seen in the endemic site Tiwi masked the influence of mutations in dhps. Resistance- related mutations in dhfr and dhps were mutually associated in both sites, which probably indicates drug selection acting on both gene-products. Mutations in pfmdr1 and pfert genes (chromosomes 7 and 5) associated with in vitro C Q resistance, were examined in the Mwea endemic site. The pfertThr76 mutation was found on presentation in all CQ-susceptible and resistant cases. The pfmdr1 mutations, Tyr86 and Tyrl246, were similarly present in most of the pre-treatment infections, but an increase in prevalence was seen in samples from recrudescent infections. Genotyping of parasite strains revealed that parasites from both endemic and epidemic areas were genetically diverse suggesting that the source of epidemic outbreaks was endemic sites of high transmission. Quantitation of parasite-specific RNA by nucleic acid sequence-based amplification (QT-NASBA) was evaluated for the detection of low malaria parasitaemias. The test maybe useful in monitoring therapeutic response to drugs.
title: SE(3) Equivariant Neural Networks for Regression on Molecular Properties
title: The QM9 Benchmark
titleType: Subtitle
Creators: name: Miller, Benjamin Kurt
Publisher: name: Freie Universität Berlin
Year: 2020
Subjects: subject: qm9
subject: deep learning
subject: neural network
subject: quantum chemistry
subject: machine learning
subject: equivariance
subject: 000 Computer science, information, and general works::000 Computer Science, knowledge, systems::004 Data processing and Computer science
subject: 600 Technology, Medicine, Applied sciences::600 Technology::600 Technology, Medicine, Applied sciences
subject: 500 Natural sciences and mathematics::540 Chemistry and allied sciences::541 Physical and theoretical chemistry

description: e3nn is an artificial neural network which operates on atomic coordinates and achieves equivariance to the special euclidean group in three dimensions by using spherical harmonics as features. The main experiment is to benchmark the model against a standard chemical data set called QM9, on which e3nn achieves state of the art performance on three of twelve regression targets. Along with empirical results, this thesis presents theoretical argumentation for why e3nn outperforms its closest relatives, SchNet and Cormorant, on some regression targets. Significant background regarding machine learning, quantum chemistry, and the special euclidean group is also presented.
[M{κ2S,S-S2C-piperazine-C2H4N=C(R)}n] {Co(III), Ni(II), Cu(II) or Zn(II)} complexes bearing pendant Schiff base moieties: spectral characterization, fluorescence, cyclic volt
Creators: name: Verma, Sanjay K.
name: Singh, Vinay K.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Physiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Cell Biology
subject: Microbiology
subject: Physics
subject: Biochemistry
subject: Biophysics

description: A series of neutral mononuclear complexes [M{κ2S,S-S2C-piperazine-C2H4N=C(R)}n] {R = Ph; M = Co(III) 1, Ni(II) 2, Cu(II) 3, Zn(II) 4; R = Naph; M = Co(III) 5, Ni(II) 6, Cu(II) 7, Zn(II) 8; n = 2 for 2–4, 6–8 and n = 3 for 1, 5} bearing pendant Schiff base moieties were synthesized through self-assembly involving N-[phenylmethylidene]-2-piperazin-1-ylethanamine (L1) or N-[naphthylmethylidene]-2-piperazin-1-ylethanamine (L2) with two equivalents each of CS2 and corresponding metal acetates. The complexes 1–8 were characterized by microanalysis, ESI-MS, IR, 1H, 13C NMR, DEPT 135, UV–visible absorption, and emission spectroscopy. Complexes 1, 3, and 8 exhibit fluorescence emissions at 342, 344, and 348 nm upon excitation at 273 (for 1 and 3) and 263 (for 8) with concomitant Stokes shifts of 69, 71, and 85 nm. The spectral and magnetic moment data support octahedral geometry around Co(III) and square planar/tetrahedral geometry around other metal centers. Thermal stabilities of 1–8 have been investigated by thermogravimteric analysis. The cyclic voltammograms clearly suggest that the complexes exhibit electroreduction principally associated with pendant imine moieties except Cu(II) complex 7 which displays quasi-reversible reduction corresponds to the Cu(II)/Cu(I) redox couples, in addition to reversible electroreduction of pendant imine groups associated with the coordinated ligands.
Autoantibody in the pathogenesis of systemic lupus erythematosus
Creators: name: Lou, Hantao
Publisher: name: Imperial College London
Year: 2017

description: SLE is an autoimmune disease characterized by the production of autoantibodies against self-antigens. Anti-dsDNA antibodies are found to correlate with SLE disease activity and it is believed that they bind to nuclear antigens to form immune complex and mediate tissue damage. The observation that serum from a subset of SLE patients impairs the neutrophil extracellular traps (NET) degradation, further suggested that autoantibodies can cause additional damage by binding to NETs. The aim of my PhD project is to study the pathogenic mechanism of the anti-dsDNA antibodies. To achieve this I cloned 200 monoclonal antibodies from two active SLE patients and characterized their reactivity to a panel of nuclear antigens including histones, chromatin, dsDNA and extractable nuclear antigens. In order to identify the pathogenic group of anti-dsDNA antibodies, their reactivity against apoptotic cells, neutrophil extracellular traps were tested by immunofluorescence and Western Blot. In addition to this, their potential binding to autoantigens in the kidney were studied by intraperitoneal injection of these mAb mice followed by immunofluorescence of the kidney specimens. Only one group of mAbs (which are histone 1 and naked dsDNA positive) deposit in the nephritic mouse kidney and they show high reactivity to both apoptotic cells and NET. Furthermore, this group of mAbs are able to stabilize the NET, prevent it from nuclease digestion. The stabilized NET-anti-dsDNA antibody immune complex enhance the type I IFN expression in monocytes. Interestingly, this mAb also facilitates apoptotic cell engulfment to suppress type I IFN expression. In summary, these findings indicate only a subgroup of anti-dsDNA antibodies are pathogenic, they deposit in diseased kidney tissue and fuel inflammation. These anti-dsDNA antibodies also stabilize NET and enhance type I IFN expression from monocytes.
Molecular diversity of neurons in the ventral tegmental area and substantia nigra pars compacta
Creators: name: Paul, Eleanor Jane
Publisher: name: Imperial College London
Year: 2017

description: Neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) are central to motivation and reward processing. These nuclei contain three core neuronal cell types: dopamine, GABA and glutamate (as well as combinatorial neurons). Dopamine neurons - the largest population - have been intensely studied, but little is known about the GABA neurons- the second largest population. They provide local inhibitory control of dopamine neurons with behavioural consequences, as well as sending long-range projections. It is unknown whether these are distinct populations of interneurons and projection neurons, or axon collaterals from the same population. Given what is known about interneurons and their control over principal cells in other networks, we hypothesised that diverse populations of interneurons are likely to be present in the VTA/SNc. However, there is no way of distinguishing them from projecting GABA populations, because there are no known molecular markers of GABA subpopulations in the VTA/SNc. My aim was to uncover novel molecular markers of subpopulations of GABA neurons in the VTA/SNc to provide new genetic entry points for future investigation of their function. First, I investigated the expression of two cardinal interneuron markers, neuronal nitric oxide synthase (nNOS) and parvalbumin (PV), in the VTA/SNc using immunostaining and viral tracing. nNOS+ neurons are present throughout the VTA/SNc and neuronal phenotype is sub-region specific. PV+ neurons are also present and they are likely to be GABA interneurons. Next, I isolated and sequenced mRNA from GABA and dopamine neurons in the midbrain using tagged polyribosomes. A comparison of transcriptomes revealed genes that are enriched in GABA neurons, offering novel candidates for subpopulation markers. These candidates were then validated through immunostaining. In conclusion, I have uncovered molecular markers of subpopulations of GABA neurons in the VTA/SNc as well as a novel population of nNOS+ glutamate neurons.
Supplementary material for ‘A sex-linked supergene with large effects on sperm traits has little impact on reproductive traits in female zebra finches’
Creators: name: Assersohn, Katherine
name: Morton, Oscar
name: Slate, Jon
name: Hemmings, Nicola
Publisher: name: The Royal Society
Year: 2024
Subjects: classificationCode: 310499
subject: Evolutionary biology not elsewhere classified
classificationCode: 3105
subject: Genetics
subject: FOS: Biological sciences
classificationCode: 310803
subject: Plant cell and molecular biology
classificationCode: 310902
subject: Animal cell and molecular biology

description: Included is a summary of the process of model interpretation: posterior predictive model checks, and probability of direction (PD) plots. Included is also: a summary of the initial attempted glmm models using a frequentist framework, a summary of the variance decomposition analysis, and samples sizes for parental genotype combinations in each analysis.
Experimental investigation and numerical simulation of creep age forming with aluminium-copper-lithium alloy 2050
Creators: name: Li, Yong
Publisher: name: Imperial College London
Year: 2017

description: This thesis presents a comprehensive research on experimental investigation and numerical modelling of the creep-ageing behaviour of a newly developed Al-Cu-Li alloy, AA2050-T34, building a solid foundation for the alloy to be manufactured through creep age forming (CAF) technology for panel products in the aerospace industry. An experimental programme has been designed and carried out to investigate the creep deformation and age hardening behaviours of the alloy at 155 ºC under both tension and compression conditions, including creep-ageing and tensile tests and microstructural observations. An asymmetric tension and compression creep-ageing behaviour and a particular double primary creep feature of the alloy have been first-time observed and the relevant mechanisms have been revealed through the microstructural analysis. A new unified constitutive model has been developed and calibrated with the experimental results. The model can well capture these microstructure-controlled mechanisms and accurately predict the asymmetric creep-ageing behaviour with the double primary creep feature of AA2050-T34. The developed constitutive equations have been implicitly resolved and implemented into the finite element (FE) software, PAM-STAMP, for CAF process simulation. CAF experiments were carried out to form some singly-curved and doubly-curved AA2050-T34 plates with different thicknesses. The simulation results of yield strength evolution during CAF and springback properties of the formed plates from CAF FE models correspond well with experimental results, validating the effectiveness of the developed FE model for CAF process simulation and prediction. The CAF FE model for AA2050-T34 developed in this thesis can now be used to assist the yield strength prediction and tool shape compensation for CAF manufacture of particular products.
Role of complement at the interface between skin and systemic inflammation
Creators: name: Giacomassi, Chiara
Publisher: name: Imperial College London
Year: 2017

description: Recent studies have uncovered the pivotal role of locally produced complement in shaping the adaptive immune responses and in modulating tissue damage in peripheral organs. However, the function played by complement during skin inflammation remains poorly understood. To investigate this, I used a model of psoriasis induced by the topical application of TLR-7 agonist 5% Imiquimod cream (IMQ). In the absence of C3, psoriatic clinical features were significantly attenuated, consistently with a contracted skin neutrophil infiltrate and production of IL-17 by gamma-delta T cells. In the skin of WT IMQ-treated animals, C3 was present only in the dermis, suggesting that C3 may act in this model as a mediator of the cross-talk between stromal cells and the innate-adaptive immune response. Guided by these observations, I then explored whether the different local inflammatory response observed in C3-/- mice translated also in altered systemic inflammation in a model of autoimmunity induced by long-term topical application of IMQ. I found that IMQ generated only a mild autoimmune response, and this was not influenced by the lack of C3. While IMQ failed to trigger an overt autoimmune response, the prolonged topical stimulation of TLR7 with R848 led to a striking monocytosis and to systemic lupus erythematosus (SLE)-features. These effects were unique to the topical application of R848 and were not influenced by the lack of C3 or C1q. Topical R848 induced a rapid enhancement of the bone marrow myelopoiesis. The monocytosis occurred independently of IFN-alpha, IL-1, CX3CR1 and CCR2, two crucial receptors involved in monocyte trafficking and homeostasis. My findings suggest a novel role for cutaneous TLR7 activation in promoting systemic immune changes. As viral ssRNA and endogenous nucleic acids represent TLR7 ligands, this model recapitulates SLE exacerbations induced by viral agents or excessive apoptosis in the skin secondary to UV-exposure.
title: LEONARD-13-2_11_30
Creators: name: Morgenstern, Aliyah
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2014
Subjects: subject: Français
subject: fra

description: C'est l'heure du dîner de Léonard. Il regarde la caméra.
description: Conforms to: doi:10.34847/cocoon.49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
description: Conforms to: Format CHAT
Identification and characterisation of novel T3SS effector proteins of Salmonella enterica serovar Typhi
Creators: name: Byrne, Alexander Matthew Patrick
Publisher: name: Imperial College London
Year: 2017

description: Salmonella enterica serovar Typhi (S. Typhi) is a Gram-negative, intracellular, human pathogen that is the causative agent of typhoid fever, responsible for 200,000 deaths worldwide, per year. Central to S. enterica pathogenesis are two type III secretion systems (T3SS), that are used to translocate up to 40 effector proteins to enable invasion, replication and manipulation of host immune responses. These proteins have been largely characterised in other S. enterica serovars and many are pseudogenes or absent from the genome of S. Typhi. The identification of a putative effector protein in S. Typhi, StoD, a member of the NleG family of bacterial E3 ubiquitin-ligase effectors, suggested that there may be more effectors in S. Typhi, than previously thought. In this study, a containment level three laboratory was established to enable the study of S. Typhi pathogenesis, and the role of novel T3SS effector proteins in this. A genome-wide machine-learning approach was then used to identify five putative effectors in S. Typhi, four of which, as well as StoD, were experimentally validated as being T3SS effectors. Whilst none of these novel effectors were found to be required for S. Typhi invasion or replication, StoD, and another novel effector, StoE, were found to localise in a punctate fashion in HeLa cells. For StoE, this localisation was shown to be dependent on a N-terminal transmembrane domain, whilst StoD was found to colocalise with the eukaryotic protein, ubiquitin, involved in protein regulation and cellular signalling. This colocalisation was demonstrated to be dependent on the E3 ubiquitin-ligase activity of StoD and whilst it was not possible to identify any substrates of StoD, further biochemical characterisation found that StoD preferentially bound K63-linked, di-ubiquitin. These findings increase the known repertoire of S. Typhi T3SS effectors from 23 to 28 proteins and suggest that further effectors could be identified.
Fourth Thing: Reference Management
Creators: name: CHARING, SARAH
name: GILMOUR, BENJAMIN
name: WALSH, GEMMA
Publisher: name: The University of Melbourne
Year: 2024
Subjects: classificationCode: 460909
subject: Information systems philosophy, research methods and theory

description: Managing your references for a research project or thesis can be time-consuming and confusing. Reference management software can make things much quicker and simpler.Using reference management software can helpOrganise your research into topic areas, chapter groups, or by paper theme to make it easier to keep track of what you are working onStore and annotate PDFsKeep notes with the bibliographic details of each item, meaning information is all kept together.Create your own personal searchable databaseEnable collaboration through sharing of groups
Responding to & Aligning with an Evolving Research Landscape
Creators: name: Lowenberg, Daniella
Publisher: name: Zenodo
Year: 2020

description: Presentation at NIH's COVID Webinar - April 24, 2020. https://datascience.nih.gov/news/nih-to-host-webinar-on-sharing-discovering-and-citing-covid-19-data-and-code-in-generalist-repositories-on-april-24
Is scholarship of teaching and learning in practical legal training a professional responsibility?
Creators: name: Greaves, Kristoffer
Publisher: name: figshare
Year: 2015
Subjects: subject: Law
subject: FOS: Law
subject: Education

description: Greaves, K 2015, 'Is scholarship of teaching and learning in practical legal training a professional responsibility?', The Law Teacher, pp. 1-17. This article focuses on responses to a paramount obligation proposition put to 34 PLT practitioners during semi-structured interviews: Might lawyers' paramount obligations to the court intersect with PLT practitioners' teaching and assessment practices?
title: LEONARD-14-3_02_25
Creators: name: Morgenstern, Aliyah
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2014
Subjects: subject: Français
subject: fra

description: C'est l'heure du dîner de Léonard. Il regarde la caméra.
description: Conforms to: doi:10.34847/cocoon.49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
description: Conforms to: Format CHAT
Fifth Thing: Project Management
Creators: name: Colla, Eleanor
Publisher: name: The University of Melbourne
Year: 2024
Subjects: classificationCode: 460909
subject: Information systems philosophy, research methods and theory

description: When projects are managed well, it helps ensure that the target objective can be delivered on time and within allocated resources. Eleanor Colla describes how each phase of the project management can help you to successfully complete your research projects.What is project management?While we all manage projects (life!) all the time, there are instances where taking a more formalised approach is required. Project management is the use of specific knowledge, skills, tools, and techniques to plan, develop, and implement a body of work with defined start and end goals and time periods.The project lifecycle is often divided into defined phases to keep on track and reach targets.
Hydrogen bonded liquid crystalline heterodimers incorporating alkoxystilbazoles and alkoxy-4-pyridones
Creators: name: Wolf, Jeremy R.
name: Dyer, Daniel J.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Biotechnology
subject: Pharmacology
subject: Cell Biology
subject: Microbiology
subject: FOS: Biological sciences
subject: Physics
subject: Biochemistry
subject: Biophysics

description: The preparation and characterisation of a series of hydrogen bonded liquid crystalline dimers containing benzoic acid, alkanoic acid and phenol donors and alkoxy-stilbazole or alkoxy-4-pyridone hydrogen bond acceptors are reported. These heterodimers possess strong intermolecular donor–acceptor hydrogen bonding. The heterodimers, as well some of the individual components used in their preparation, possess liquid crystalline phases.
Isolation and molecular characterisation of chicken parvovirus from Brazilian flocks with enteric disorders
Creators: name: E. Mettifogo
name: L.F.N. Nuñez
name: S.H. Santander Parra
name: C.S. Astolfi-Ferreira
name: A.J. Piantino Ferreira
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Medicine
subject: 60506 Virology
subject: FOS: Biological sciences
subject: Biological Sciences
subject: Ecology
subject: Earth and Environmental Sciences
subject: Genetics
subject: Cell Biology
subject: Microbiology

description: 1. The presence of parvovirus in chickens with enteric disease was investigated in commercial flocks in Brazil.2. The intestinal contents of chickens exhibiting clinical signs of diarrhoea, weight loss or mortality were examined, and chicken parvovirus (chPV) was identified using a polymerase chain reaction (PCR) assay. The samples were sequenced and inoculated into specific-pathogen-free (SPF) embryonated eggs to isolate the virus.3. Necropsies showed that the embryos were dwarfish, haemorrhagic and oedematous. The presence of chPV was confirmed by PCR and DNA sequencing.4. The molecular characterisation of chPV strains circulating in the Brazilian flocks showed that they were genetically related to sequences from North America, Europe and Asia. Phylogenetic analyses clustered the Brazilian chPV sequences with those from Europe (Croatia, Hungary) and Asia (South Korea).5. This study is the first report of the molecular characterisation of chPV circulating in the commercial flocks in Brazil and indicates high genetic similarity with chPV sequences from around the world.
Agile software development – do we really calculate the costs? A multivocal literature review
Creators: name: Fogarty, Aidan
name: Edgeworth, Aaron
name: Smith, Oishin
name: Dowling, Michael
name: Yilmaz, Murat
name: MacMahon, Silvana Togneri
name: Clarke, Paul
Publisher: name: University of Limerick
Year: 2024
Subjects: classificationCode: 4612
subject: Software engineering

description: Agile software development methods, in their various different forms, have become the basis for most software projects in today’s world. The methodology is present in almost all organisations today. However, despite the popularity, failure rates in software projects remain high. This paper identifies why agile methodologies have become so successful. In addition, the paper discusses certain factors that may often be overlooked in organisations that have adopted agile methods, such as rework, maintainability, adoption, turnover rates and the potential costs associated with each. The research carried out was a multivocal literature review (MLR). Multiple white and grey literature which was deemed to be relevant was selected. 32 contributions from white literature were selected for use in the review as well as 8 from grey literature sources. We find that while agile has many advantages, organisations may overlook the potential downsides of using an agile methodology. If not managed or implemented correctly, organisations risk taking on more hidden and expensive costs, for example in relation to rework. It is important that organisations are sufficiently trained in agile methods in order to succeed.
Learning at every age? Life cycle dynamics of adult education in Europe
Creators: name: Beblavy, Miroslav
name: Anna-Elizabeth Thum
name: Potjagailo, Galina
Publisher: name: figshare
Year: 2015
Subjects: Education

description: Adult learning is seen as a key factor for enhancing employment, innovation and
growth. The aim of this paper is to understand the points in the life cycle at which
adult learning takes place and whether it leads to reaching a medium or high level of
educational attainment. We perform a synthetic panel analysis of adult learning for
cohorts aged 25–64 in 27 European countries using the European Union Labour Force
Survey. We find that investment across the life cycle by cohorts older than 25 still
occurs: participation in education and training as well as educational attainment
increase observably across all cohorts. We also find that the decline with age slows
down, or is even reversed for older cohorts, for both participation in education and
educational attainment. Finally, we can identify cross-country differences in approach.
In Nordic countries, adult learning is achieved primarily through participation in
education and training without adding to formal educational attainment. In central
Europe, adult learning occurs primarily in the form of increasing educational
attainment. In Ireland and the UK, a combination of both approaches to adult learning
is observable.
Chemical and morphological stability of Perovskite and organic solar cells
Creators: name: Pont, Sebastian Andrew Victor
Publisher: name: Imperial College London
Year: 2018

description: The stability of perovskite and organic solar cells remains a major challenge to realise their potential. To overcome the numerous degradation mechanisms, it is important to understand the underlying causes. This thesis will present device and material characterisation on two areas: firstly, elucidating perovskite environmental stability and, secondly, the effects of PCBM dimerisation in organic solar cells. The first results chapter investigates the environmental stability of methylammonium lead iodide. In this thesis, degradation under light and oxygen is found to be more detrimental than humidity. Injected charge (not photogenerated) also induce the degradation with oxygen; thus, all optoelectronic applications are vulnerable. Efficient electron extraction minimises superoxide generation and subsequent degradation. These results determine the dominant environmental instability and present pathways to curtail it. The second results chapter explores halide tuning of methylammonium lead iodide-bromide (MAPI-Br) to optimise environmental stability. The stability of thin films and solar cells for all halide ratios is investigated under light and oxygen stress and humid nitrogen stress. Partial bromide substitution does not improve stability. However, for MAPBr, the crystal structure and optical properties are unchanged after 120 h of light and oxygen stress. It is concluded that iodide limits mixed halide stability and MAPBr has excellent environmental stability for high voltage solar cell applications. The third results chapter investigates the morphological stability of polystyrene:PCBM blends under simultaneous light and thermal stress. Neutron reflectivity and atomic force microscopy are used to probe the vertical stratification and topography, respectively. It is found that PCBM dimerisation inhibits both surface relaxation and PCBM enrichment to the bottom PEDOT:PSS interface. Modelling the diffusion shows PCBM dimers to be effectively immobile over the timescales investigated. These results present a framework to understand polymer:fullerene morphological stability under operating conditions. The final results chapter develops a complete model to describe PCBM dimerisation. Predicting the photo-dimerisation and thermal decomposition within any polymer matrix, under any light and temperature profile. During operating conditions, the PCBM dimer will dominate the reaction equilibrium; therefore, clarifying the role of dimers is critical. Evidence of distinct dimer populations is observed with differing chemical and electronic properties. DFT simulations conclude this is due to PCBM dimer conformations. These results can rationalise the double-edged effects of PCBM dimerisation previously reported.
Evolutionary systems biology of virus-host interactions
Creators: name: Fernandes De Brito, Anderson
Publisher: name: Imperial College London
Year: 2018

description: The evolution of virus-host interactions occurs at multiple levels of biological complexity, such as organismal, genetic, and molecular levels. In the first part of this study, the evolution of associations between herpesviruses (HVs) and theirhosts are examined across more than 400 million years. Recent studies have been demonstrating that cospeciations are not always the main event driving HV evolution, asinterhost speciations and host switches also play important roles. The present study shows that more than topological incongruences, mismatches on divergence times are the main source of disagreements between host and viral phylogenies, which reveals host switches, intrahost speciations and viral losses along the evolution of HVs. Herpesviruses have large genomes encoding dozens of proteins. Apart from amino acid substitutions, these viruses also evolve by acquiring, duplicating and losing protein domains. Although the domain repertoires of HVs differ across species, a core set of domains is shared among all of them. This second part of this study reveals that 28 out 41 core domains encoded by HV ancestors are still found in present-day repertoires, which over time were expanded by domain gains and duplications. Distinct evolutionary strategies led HVs to developed very specific domain repertoires, which may explain their host range and tissue tropism, and provide hints on the origins of herpesviruses. Despite the fact that most mutations in proteins are deleterious, few of them end up improving viral fitness and defining how viruses interact with their hosts. By using an integrative approach, the third part of this study investigates the evolution of protein-protein interactions (PPIs) involving the membrane proteins Nectins, and the herpesviral envelope glycoproteins D/G. By means of ancestral sequence reconstruction and homology modelling, ancestral structures of these protein complexes were generated, and analysis of their interaction energies revealed important differences of binding affinity along their evolution.
Dissecting the mechanics of erythrocyte invasion by the Plasmodium parasite
Creators: name: Koch, Marion
Publisher: name: Imperial College London
Year: 2018

description: Erythrocyte invasion by the malaria parasite P. falciparum is a complex molecular process encompassing numerous receptor host-parasite interactions with varying levels of redundancy. To date, much of the research into merozoite invasion has focused on the constituents and structure of the parasite's actin-myosin motor, which drives cell entry, and the essentiality of receptor-ligand interactions. However, despite significant recent advances in these areas of research, we still know very little about what many parasite ligands mechanistically do. Additionally, despite the fact that a number of erythrocyte receptors utilised during invasion are known to trigger cytoskeletal and biophysical changes when bound by antibodies, a potential role for signaling pathways within the erythrocyte has largely been ignored. The work presented here, explores whether binding of parasite ligands trigger signalling events, in particular biophysical changes, that facilitate merozoite invasion. Using two biophysical techniques, real-time deformability cytometry and flicker spectroscopy, this work demonstrates that binding of the parasite ligand EBA175 to its erythrocyte receptor GPA triggers a complex set of biophysical events in the red cell leading to an increase in erythrocyte tension and a reduction in the cell's bending modulus. Combining the biophysical work with quantitative merozoite invasion assays I show that the reduction in the red cell bending modulus is directly correlated with parasite invasion efficiency. Based on the link between erythrocyte membrane biophysics and parasite invasion, I further explored how dyslipidemia affect these properties using a mouse model of hypercholesterolemia. The work presented here strongly suggests that the change in the erythrocyte bending modulus, triggered by parasite-host interactions, lowers the energy requirement for bending the red cell membrane and significantly contributes to merozoite invasion efficiency. It further raises questions about potential links between conditions which lead to high cholesterol, such as hypercholesterolemia, red cell lipid composition and malaria.
Education and social protection policies in OECD countries: Social stratification and policy intervention
Creators: name: Beblavy, Miroslav
name: Anna-Elisabeth Thum
name: Potjagailo, Galina
Publisher: name: figshare
Year: 2015
Subjects: Education

description: We examine the relationship between education and social protection policies across OECD countries and
thereby contribute to the growing political and academic discussion on how social investment and social
protection are interrelated. We focus on how government policy in two policy domains (education, social
protection) affects social stratification. The paper is based on a principal methodological innovation, which
lies in disaggregating the ways in which policy-makers influence stratification into two distinct dimensions:
one is concerned with how much the state intervenes in the provision of education/social protection and
how much it leaves to individual, family and market, and the second is concerned with the bias towards
equality or stratification found in the state system itself. We find that countries can be grouped into a
distinct number of education–social protection typologies, which differ from traditional clusterings and
could indicate the need for multi-faceted pan-European education policies that take into account the
longstanding differences in stratification as opposed to one-size-fits-all policy initiatives.
Quantification of knee extensor muscle forces: a multimodality approach
Creators: name: Ahmadzadeh, Seyed Mohammad Hassan
Publisher: name: Imperial College London
Year: 2018

description: Given the growing interest of using musculoskeletal (MSK) models in a large number of clinical applications for quantifying the internal loading of the human MSK system, verification and validation of the model’s predictions, especially at the knee joint, have remained as one of the biggest challenges in the use of the models as clinical tools. This thesis proposes a methodology for more accurate quantification of knee extensor forces by exploring different experimental and modelling techniques that can be used to enhance the process of verification and validation of the knee joint model within the MSK models for transforming the models to a viable clinical tool. In this methodology, an experimental protocol was developed for simultaneous measurement of the knee joint motion, torques, external forces and muscular activation during an isolated knee extension exercise. This experimental protocol was tested on a cohort of 11 male subjects and the measurements were used to quantify knee extensor forces using two different MSK models representing a simplified model of the knee extensor mechanism and a previously-developed three-dimensional MSK model of the lower limb. The quantified knee extensor forces from the MSK models were then compared to evaluate the performance of the models for quantifying knee extensor forces. The MSK models were also used to investigate the sensitivity of the calculated knee extensor forces to key modelling parameters of the knee including the method of quantifying the knee centre of rotation and the effect of joint translation during motion. In addition, the feasibility of an emerging ultrasound-based imaging technique (shear wave elastography) for direct quantification of the physiologically-relevant musculotendon forces was investigated. The results in this thesis showed that a simplified model of the knee can be reliably used during a controlled planar activity as a computationally-fast and effective tool for hierarchical verification of the knee joint model in optimisation-based large-scale MSK models to provide more confidence in the outputs of the models. Furthermore, the calculation of knee extensor muscle forces has been found to be sensitive to knee joint translation (moving centre of rotation of the knee), highlighting the importance of this modelling parameter for quantifying physiologically-realistic knee muscle forces in the MSK models. It was also demonstrated how the movement of the knee axis of rotation during motion can be used as an intuitive tool for understanding the functional anatomy of the knee joint. Moreover, the findings in this thesis indicated that the shear wave elastography technique can be potentially used as a novel method for direct quantification of the physiologically-relevant musculotendon forces for independent validation of the predictions of musculotendon forces from the MSK models.