cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Resolution Adaptive Fixed Rank Kriging
Creators: name: Tzeng, ShengLi
name: Hsin-Cheng Huang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Plant Biology

description: The spatial random effects model is flexible in modeling spatial covariance functions and is computationally efficient for spatial prediction via fixed rank kriging (FRK). However, the model depends on a class of basis functions, which if not selected properly, may result in unstable or undesirable results. Additionally, the maximum likelihood (ML) estimates of the model parameters are commonly computed using an expectation- maximization (EM) algorithm, which further limits its applicability when a large number of basis functions are required. In this research, we propose a class of basis functions extracted from thin-plate splines. The functions are ordered in terms of their degrees of smoothness with higher-order functions corresponding to larger-scale features and lower-order ones corresponding to smaller-scale details, leading to a parsimonious representation of a (nonstationary) spatial covariance function with the number of basis functions playing the role of spatial resolution. The proposed class of basis functions avoids the difficult knot-allocation or scale-selection problem. In addition, we show that ML estimates of the random effects covariance matrix can be expressed in simple closed forms, and hence the resulting FRK can accommodate a much larger number of basis functions without numerical difficulties. Finally, we propose to select the number of basis functions using Akaike's information criterion, which also possesses a simple closed-form expression. The whole procedure, involving no additional tuning parameter, is efficient to compute, easy to program, automatic to implement, and applicable to massive amounts of spatial data even when they are sparsely and irregularly located. Proofs of the theorems and an R package autoFRK are provided in supplementary materials available online.
Reusable Poly(allylamine)-Based Solid Materials for Carbon Dioxide Capture Under Continuous Flow of Ambient Air
Creators: name: Tipirneni, Anil
name: Zerze, Hasan
name: Hallak, Daniel
name: McHugh, Anthony J.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: Poly(allylamine) (PAA) is prepared via free-radical polymerization and physically impregnated on fumed silica at various amine loadings. The PAA-silica composites were found to have significant potential as trace carbon dioxide adsorbents under ambient conditions. The sorbent materials are shown to have high adsorption capacities with desirable adsorption-desorption characteristics. The effects of temperature and humidity on adsorption capacity and kinetics were studied at near ambient conditions. Sorbent regenerative ability was confirmed within around 8% change following subsequent adsorption-desorption cycles and thermogravimetric analysis.
Efficient multicomponent synthesis of spiro[indoline-3,4′-thiopyran]-2-ones
Creators: name: Kurva, Srinivas
name: Vinodkumar Sriramoju
name: Sridhar Madabhushi
name: Jagadeesh Babu Nanubolu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Plant Biology

description: Synthesis of new thiopyran fused spirooxindoles (spiro[indoline-3,4′-thiopyran]-2-ones) were achieved by a multicomponent reaction of N-methyl isatin, malononitrile/ethyl cyanoacetate, and β-oxodithioester using N,N′-dimethylaminopyridine as the catalyst.
APPLICATION OF THERAPEUTIC COMMUNICATION AS A TALKING TECHNIQUE BETWEEN NURSES AND PATIENTS
Creators: name: Loso Judijanto
name: Siti Solihat Holida
name: Ganjar Safari
name: Nia Restiana
name: Fitri Nurlina
name: Miftahul Falah
name: Andiyan Andiyan
Publisher: name: Zenodo
Year: 2024
Subjects: Communication, Therapeutic, Patient, Nurse, Interpersonal.

description: Abstract

One of the main health issues in developing countries is the problem of public health disruption caused Therapeutic communication encompasses interpersonal interactions that facilitate mutual comprehension and empathy between nurses and patients. The essential problem of communication is the mutual dependency between nurses and patients, therefore falling under the category of personal communication between nurses and patients. Research design is a methodology used by researchers to gather and examine pertinent material in relation to their research inquiry. The research design is used to ascertain the framework of the investigation. The research design adopted in this study is descriptive. Therapeutic communication is a crucial kind of communication that is intentionally designed and focused on facilitating the patient's healing and recovery. Nurses should ensure that all their actions and statements directed towards patients have a therapeutic aim. Therapeutic communication involves the nurse's manner of communication and the establishment of a mutually beneficial connection with the patient, with the goal of promoting the patient's recovery. The interaction between the patient and the therapeutic nurse is a mutually beneficial educational encounter that contributes to the patient's emotional well-being. Effective therapeutic communication between patients and nurses is essential for fostering mutual respect.
Interaction between the ADH1B*3 allele and drinking motives on alcohol use among Black college students
Creators: name: Zaso, Michelle J.
name: Desalu, Jessica M.
name: Jueun Kim
name: Suryadevara, Kavita
name: Belote, John M.
name: Aesoon Park
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Background: Black young adults have lower rates of alcohol use than other racial groups. Genetic factors may protect against drinking. Specifically, the ADH1B*3 allele is present almost exclusively in Black populations and has been protective against alcohol use and alcohol use disorder. The protective effects of the ADH1B*3 allele, however, may differ as a function of alcohol-promoting cognitions. Objectives: The current study examined whether ADH1B*3 moderated relations of drinking motives with alcohol consumption among Black college drinkers. Methods: Participants were 241 undergraduate students of self-identified Black race (mean age = 20 years; 66% female) who reported consuming alcohol at least once in the past 30 days. Results: ADH1B*3 was not significantly associated with drinking motives or drinking behaviors. However, significant, albeit small, interaction effects of ADH1B*3 with drinking motives on drinking behavior were found; the presence of an ADH1B*3 allele protected against greater drinking quantity among students with high social motives (incidence rate ratio [IRR] = 0.95, 95% CI [0.92, 0.99]) and against frequent drinking among students with low coping motives (IRR = 1.06, 95% CI [1.01, 1.11]). Conclusion: These findings represent a novel demonstration of genetic modulation of alcohol-related cognitions within Black college drinkers, although replication is needed. Results represent an initial step toward better characterizing individual differences in associations of drinking motives with drinking behavior, with potential implications for interventions aimed at motivational processes in alcohol use.
Potential applications of luminescent molecular rotors in food science and engineering
Creators: name: Fatemah M. Alhassawi
name: Corradini, Maria G.
name: Rogers, Michael A.
name: Ludescher, Richard D.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Plant Biology

description: Fluorescent molecular rotors (MRs) are compounds whose emission is modulated by segmental mobility; photoexcitation generates a locally excited (LE), planar state that can relax either by radiative decay (emission of a photon) or by formation of a twisted intramolecular charge transfer (TICT) state that can relax nonradiatively due to internal rotation. If the local environment around the probe allows for rapid internal rotation in the excited state, fast non-radiative decay can either effectively quench the fluorescence or generate a second, red-shifted emission band. Conversely, any environmental restriction to twisting in the excited state due to free volume, crowding or viscosity, slows rotational relaxation and promotes fluorescence emission from the LE state. The environmental sensitivity of MRs has been exploited extensively in biological applications to sense microviscosity in biofluids, the stability and physical state of biomembranes, and conformational changes in macromolecules. The application of MRs in food research, however, has been only marginally explored. In this review, we summarize the main characteristics of fluorescent MRs, their current applications in biological research and their current and potential applications as sensors of physical properties in food science and engineering.
Automatização de Processos como Estratégia de Redução de Custos e Aumento de Eficiência: Uma Análise Integrada com Práticas de Melhoria Contínua
Creators: name: Kellner, Fátima Serralheiro
Publisher: name: Zenodo
Year: 2025
Subjects: Fátima Serralheiro Kellner

description: Profissional com formação jurídica e sólida atuação em gestão estratégica e financeira nos EUA, especialista em inovação, contratos e liderança, com foco em eficiência operacional, sustentabilidade e desenvolvimento de pequenas empresas.
Identification of Acinetobacter baumannii Type VI Secretion System Targets and Toxins
Creators: name: TIMOTHY CRAIG FITZSIMONS
Publisher: name: Monash University
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: The pathogen Acinetobacter baumannii utilises its T6SS to kill rival bacteria. We identified three toxins required for bacterial killing as well as the immunity proteins that protect A. baumannii from killing its sister cells. One of these toxins was confirmed to act by degrading target cell DNA. Each of these three toxins was found to be dependent upon a co-encoded VgrG protein for its secretion. Finally, analysis of the genomes of a variety of A. baumannii genomes identified significant diversity among potential secreted toxins at the strain level providing insight into how strains of A. baumannii have become globally distributed.
Efficient Multicomponent Synthesis of Spiro[Indoline-3,4′-thiopyran]-2-ones
Creators: name: Kurva, Srinivas
name: Vinodkumar Sriramoju
name: Sridhar Madabhushi
name: Jagadeesh Babu Nanubolu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Plant Biology

description: Synthesis of new thiopyran fused spirooxindoles (spiro[indoline-3,4′-thiopyran]-2-ones) were achieved by a multicomponent reaction of N-methyl isatin, malononitrile/ethyl cyanoacetate and β-oxodithioester using DMAP as the catalyst.
Potential Applications of Luminescent Molecular Rotors in Food Science and Engineering
Creators: name: Fatemah M. Alhassawi
name: Corradini, Maria G.
name: Rogers, Michael A.
name: Ludescher, Richard D.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Plant Biology

description: Fluorescent molecular rotors are compounds whose emission is modulated by segmental mobility; photoexcitation generates a locally excited (LE), planar state that can relax either by radiative decay (emission of a photon) or by formation of a twisted intramolecular charge transfer (TICT) state that can relax non-radiatively due to internal rotation. If the local environment around the probe allows for rapid internal rotation in the excited state, fast non-radiative decay can either effectively quench the fluorescence or generate a second, red-shifted emission band. Conversely, any environmental restriction to twisting in the excited state due to free volume, crowding or viscosity, slows rotational relaxation and promotes fluorescence emission from the LE state. The environmental sensitivity of molecular rotors has been exploited extensively in biological applications to sense microviscosity in biofluids, the stability and physical state of biomembranes, and conformational changes in macromolecules. The application of molecular rotors in food research, however, has been only marginally explored. In this review, we summarize the main characteristics of fluorescent molecular rotors, their current applications in biological research and their current and potential applications as sensors of physical properties in food science and engineering.
Additional file 2 of Recurrent colorectal liver metastasis patients could benefit from repeat hepatic resection
Creators: name: Liu, Wei
name: Liu, Jia-Ming
name: Wang, Kun
name: Wang, Hong-Wei
name: Xing, Bao-Cai
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 2: Figure S2. The definition of early recurrence using the minimum p value approach by an optimal cutoff point regarding the time to first recurrence.
Promiscuous Signaling by a Regulatory System Unique to the Pandemic PMEN1 Pneumococcal Lineage
Creators: name: Anagha Kadam
name: Eutsey, Rory
name: Rosch, Jason
name: Xinyu Miao
name: Longwell, Mark
name: Wenjie Xu
name: Woolford, Carol
name: Hillman, Todd
name: Anfal Shakir Motib
name: Yesilkaya, Hasan
name: Mitchell, Aaron
name: Hiller, Natalia
Publisher: name: Carnegie Mellon University
Year: 2017
Subjects: subject: 60408 Genomics
subject: FOS: Biological sciences
subject: 60111 Signal Transduction

description: Streptococcus pneumoniae (pneumococcus) is a leading cause of death and disease in children and elderly. Genetic variability among isolates from this species is high. These differences, often the product of gene loss or gene acquisition via horizontal gene transfer, can endow strains with new molecular pathways, diverse phenotypes, and ecological advantages. PMEN1 is a widespread and multidrug-resistant pneumococcal lineage. Using comparative genomics we have determined that a regulator-peptide signal transduction system, TprA2/PhrA2, was acquired by a PMEN1 ancestor and is encoded by the vast majority of strains in this lineage. We show that TprA2 is a negative regulator of a PMEN1-specific gene encoding a lanthionine-containing peptide (lcpA). The activity of TprA2 is modulated by its cognate peptide, PhrA2. Expression of phrA2 is density-dependent and its C-terminus relieves TprA2-mediated inhibition leading to expression of lcpA. In the pneumococcal mouse model with intranasal inoculation, TprA2 had no effect on nasopharyngeal colonization but was associated with decreased lung disease via its control of lcpA levels. Furthermore, the TprA2/PhrA2 system has integrated into the pneumococcal regulatory circuitry, as PhrA2 activates TprA/PhrA, a second regulator-peptide signal transduction system widespread among pneumococci. Extracellular PhrA2 can release TprA-mediated inhibition, activating expression of TprA-repressed genes in both PMEN1 cells as well as another pneumococcal lineage. Acquisition of TprA2/PhrA2 has provided PMEN1 isolates with a mechanism to promote commensalism over dissemination and control inter-strain gene regulation.
Additional file 3 of Recurrent colorectal liver metastasis patients could benefit from repeat hepatic resection
Creators: name: Liu, Wei
name: Liu, Jia-Ming
name: Wang, Kun
name: Wang, Hong-Wei
name: Xing, Bao-Cai
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 3: Figure S3. Kaplan-Meier curve showing the OS and DFS of 867 patients.
Drapieżne czasopisma jako przykład nieetycznego publikowania
Creators: name: Burdzik, Tomasz
Publisher: name: figshare
Year: 2020
Subjects: subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: 130103 Higher Education
subject: FOS: Educational sciences

description: Publication name:  Burdzik, T. (2017). Drapieżne czasopisma jako przykład nieetycznego publikowania. Filozofia i Nauka. Studia filozoficzne i interdyscyplinarne, 5, 131–149. doi: 10.6084/m9.figshare.5155939 Abstrakt: Artykuł opisuje zjawisko “drapieżnych czasopism”, przedstawia ich charakterystyczne cechy, takie jak spamowanie czy wykorzystywanie fałszywych metryk oraz opisuje spowodowane tym problemy przynoszące szkodę nauce. Drapieżne czasopisma często nie prowadzą rzetelnego procesu recenzyjnego, pozwalając na tworzenie pseudonauki pod pozorem prawdziwej nauki. Drapieżne czasopisma często mają fikcyjny zespół redakcyjny, nie są przejrzyste w kwestiach finansów oraz siedziby, zawierają plagiaty i publikują niemalże wszystko. Wydawcy drapieżnych czasopism zachowują się nieetycznie. W zakończeniu artykułu wskazane jest, jak można uniknąć bycia ofiarą drapieżnych czasopism oraz jak można walczyć z drapieżnymi czasopismami. Słowa kluczowe: drapieżne czasopisma, drapieżni wydawcy, etyka publikacyjna, etyka w nauce Abstract: This paper describes the phenomenon of predatory journals, the characteristics of predatory journals, including spamming and using fake metrics, and the problems they cause for science. Predatory journals often fail to properly manage peer review, allowing pseudo-science to be published dressed up as authentic science. Predatory journals frequently have imaginary editorial boards, do not operate any quality control, are unclear about payment requirements and about ownership or location, include plagiarised content. Predatory publishers generally behave unethically. Towards the end of the paper it is discussed what can and should be done to eliminate or reduce the effects of this development and how researchers can avoid becoming victimized by them. Keywords: predatory journals, predatory publishers, publication ethics , ethics in science
D4.10 Games release - Final
Creators: name: STARS4ALL Project
Publisher: name: figshare
Year: 2017
Subjects: subject: 50206 Environmental Monitoring
subject: FOS: Earth and related environmental sciences

description: This deliverable is the final software implementation of the games developed within WP4. The current document represents the textual description of the software release.
Additional file 6 of Recurrent colorectal liver metastasis patients could benefit from repeat hepatic resection
Creators: name: Liu, Wei
name: Liu, Jia-Ming
name: Wang, Kun
name: Wang, Hong-Wei
name: Xing, Bao-Cai
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 6: Figure S5. The OS of the high-risk (score ≥ 13) and low-risk groups (score < 13) by a Kaplan-Meier curve.
D5.8 Tools for crowdsourcing activities
Creators: name: STARS4ALL Project
Publisher: name: figshare
Year: 2017
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences
subject: 80703 Human Information Behaviour
subject: FOS: Media and communications

description: This deliverable reported about the reference model for the machine learning methods to perform image classification as a complementary tool for the STARS4ALL crowdsourcing activities; the main metrics to evaluate crowdsourcing
activities and machine learning models are illustrated; a method to compare the crowdsourcing and the machine learning approaches is presented; an example
of result evaluation and comparison, based on the data collected during the Night Knights game trial phase, is also included to exemplify our approach.

Keywords Machine Learning, Image Classification, Crowdsourcing, Citizen Science, Hum
title: saint Edme
Creators: name: Centre De Recherches Historiques / Anthropologie Historique Du Long Moyen Âge
Publisher: name: EHESS (School for Advanced Studies in Social Sciences)
Year: 2019

description: Saint anglais, archevêque de Cantorbéry, mort en France en 1242 ; attributs : un enfant nu ou emmailloté, couché sur un berceau ou sur un matelas.
title: saint Bruno
Creators: name: Centre De Recherches Historiques / Anthropologie Historique Du Long Moyen Âge
Publisher: name: EHESS (School for Advanced Studies in Social Sciences)
Year: 2019

description: Fondateur du monastère de la Grande-Chartreuse, maison mère de l'ordre des chartreux, mort en 1101 ; représenté en robe blanche, il porte une étoile sur la poitrine ; la mitre et la crosse sous ses pieds; une tête de mort, un crucifix arborescent, un rameau d'olivier ; parfois il met un doigt sur ses lèvres en signe de silence.
Drapieżne czasopisma jako przykład nieetycznego publikowania
Creators: name: Burdzik, Tomasz
Publisher: name: figshare
Year: 2017
Subjects: subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: 130103 Higher Education
subject: FOS: Educational sciences

description: Publication name:  Burdzik, T. (2017). Drapieżne czasopisma jako przykład nieetycznego publikowania. Filozofia i Nauka. Studia filozoficzne i interdyscyplinarne, 5, 131–149. doi: 10.6084/m9.figshare.5155939 Abstrakt: Artykuł opisuje zjawisko “drapieżnych czasopism”, przedstawia ich charakterystyczne cechy, takie jak spamowanie czy wykorzystywanie fałszywych metryk oraz opisuje spowodowane tym problemy przynoszące szkodę nauce. Drapieżne czasopisma często nie prowadzą rzetelnego procesu recenzyjnego, pozwalając na tworzenie pseudonauki pod pozorem prawdziwej nauki. Drapieżne czasopisma często mają fikcyjny zespół redakcyjny, nie są przejrzyste w kwestiach finansów oraz siedziby, zawierają plagiaty i publikują niemalże wszystko. Wydawcy drapieżnych czasopism zachowują się nieetycznie. W zakończeniu artykułu wskazane jest, jak można uniknąć bycia ofiarą drapieżnych czasopism oraz jak można walczyć z drapieżnymi czasopismami. Słowa kluczowe: drapieżne czasopisma, drapieżni wydawcy, etyka publikacyjna, etyka w nauce Abstract: This paper describes the phenomenon of predatory journals, the characteristics of predatory journals, including spamming and using fake metrics, and the problems they cause for science. Predatory journals often fail to properly manage peer review, allowing pseudo-science to be published dressed up as authentic science. Predatory journals frequently have imaginary editorial boards, do not operate any quality control, are unclear about payment requirements and about ownership or location, include plagiarised content. Predatory publishers generally behave unethically. Towards the end of the paper it is discussed what can and should be done to eliminate or reduce the effects of this development and how researchers can avoid becoming victimized by them. Keywords: predatory journals, predatory publishers, publication ethics , ethics in science
Phosphodiesterase-5 inhibitors and their analogues as adulterants of herbal and food products: analysis of the Malaysian market, 2014–16
Creators: name: Bujang, Nur Baizura
name: Chee, Chin Fei
name: Heh, Choon Han
name: Noorsaadah Abd. Rahman
name: Buckle, Michael J. C.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Science Policy

description: Adulteration of herbal health supplements with phosphodiesterase-5 (PDE-5) inhibitors and their analogues is becoming a worldwide problem. The aim of this study was to investigate herbal and food products sold in the Malaysian market for the presence of these adulterants. Sixty-two products that claim to enhance men’s sexual health were sampled between April 2014 and April 2016. These products included unregistered products seized by the Pharmacy Enforcement Division of the Ministry of Health (n = 39), products sent to the National Pharmaceutical Regulatory Agency for pre-registration testing (n = 9) and products investigated under the post-registration market surveillance programme (n = 14). The products were tested against an in-house spectral library consisting of 61 PDE-5 inhibitors and analogues using a validated liquid chromatography-mass spectrometry ion-trap-time-of-flight (LC-MS IT-TOF) method. Thirty-two (82%) of the unregistered products and two (14%) of the registered products were found to be adulterated with at least one PDE-5 inhibitor or analogue, while none of the pre-registration products contained adulterants. A total of 16 different adulterants were detected and 36% of the adulterated products contained a mixture of two or more adulterants. This study has demonstrated that the adulteration of unregistered herbal products in the Malaysian market is an alarming issue that needs to be urgently addressed by the relevant authorities.
THE PERCEPTIONS OF SMMES OWNERS/MANAGERS TOWARDS ADOPTING AND USING SOCIAL MEDIA FOR SMMES SURVIVAL AND GROWTH DURING THE COVID-19 CRISIS IN RURAL KWAZULU-NATAL
Creators: name: SABELO  MPUNGOSE
name: LAWRENCE MPELE  LEKHANYA
name: EMEM ANWANA
Publisher: name: Zenodo
Year: 2024
Subjects: SMMEs, Social Media, Covid-19 Crisis, Survival, Growth, Rural KZN, SMMEs Perceptions.

description: Abstract

The Covid-19 crisis has posed critical challenges on survival and growth of Small, Medium and Micro Enterprises (SMMEs) worldwide, particularly in rural areas such as KwaZulu-Natal (KZN). This study investigated the influence of perceptions of rural SMMEs owners / managers regarding adoption and usage of social media as a tool for survival and growth during the Covid-19 crisis. The quantitative design was adopted, and data was collected from 374 rural SMMEs in KZN by a questionnaire. The study employed convenience, purposive, and quota sampling techniques. The data collected were analysed using the statistical package for social sciences (SPSS) (version 27.0). The study revealed that rural SMMEs had a negative perception in adopting and using social media during the Covid-19 crisis. The recommendations of the study suggested that rural SMMEs should use social media to network with more customers and SMME owners /managers need to adopt social media strategy implementation to reduce management perceptions constraints led to business failure regarding rural SMMEs survival and growth during Covid-19 crisis.
ЭФФЕКТИВНЫЕ МЕХАНИЗМЫ ПОВЫШЕНИЯ КАЧЕСТВА ОБРАЗОВАНИЯ
Creators: name: Турсунова, Луиза
name: Жураев, Сухробжон
Publisher: name: Zenodo
Year: 2024

description: в данной статье рассматривается эффективные механизмы повышения качества образования. А именно цифровизация учебного процесса. Рассматриваются этапы цифровизации учебного процесса. Ключевые моменты, способствующие развитию цифровой грамотности у обучающихся и педагогов. Описаны методы подготовки педагогов по информационным технологиям.
Additional file 1 of Chrysoeriol suppresses hyperproliferation of rheumatoid arthritis fibroblast-like synoviocytes and inhibits JAK2/STAT3 signaling
Creators: name: Wu, Jia-Ying
name: Chen, Ying-Jie
name: Fu, Xiu-Qiong
name: Li, Jun-Kui
name: Chou, Ji-Yao
name: Yin, Cheng-Le
name: Bai, Jing-Xuan
name: Wu, Ying
name: Wang, Xiao-Qi
name: Li, Amy Sze-man
name: Wong, Lut Yi
name: Yu, Zhi-Ling
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: Additional file 1. Effects of CSR on the proliferation of IL-6/sIL-6R-stimulated MIHA and L929 cells. (a) MIHA cell viability. (b) L929 cell viability. In (a) and (b), cells were incubated with indicated concentrations of CSR for 1hr and then stimulated with IL-6/sIL-6R (100 ng/ml each) for 24 hrs. Cell viability was detected using CCK8 assays. Data are expressed as mean ± SD of 3 independent experiments.* P < 0.05 vs. IL-6/sIL-6R plus CSR solvent-treated group.
VEGFR-2 inhibitors and apoptosis inducers: synthesis and molecular design of new benzo[g]quinazolin bearing benzenesulfonamide moiety
Creators: name: Ghorab, Mostafa M.
name: Alsaid, Mansour S.
name: Soliman, Aiten M.
name: Ragab, Fatma A.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Two series of novel 4-(2-(2-(2-(substituted) hydrazinyl)-2-oxoethylthio)-4-oxobenzo[g]quinazolin-3(4H)-yl) benzenesulfonamide 5–17 and 4-(2-(2-(substituted-1H-pyrazol-1-yl)-2-oxoethylthio)-4-oxobenzo[g]quinazolin-3(4H)-yl) benzenesulfonamide 18–24 were synthesised from the starting material 4-(2-(2-hydrazinyl-2-oxoethylthio)-4-oxobenzo[g]quinazolin-3(4H)-yl) benzenesulfonamide 5, to be evaluated for their inhibitory activity towards VEGFR-2. The target compounds 5–24, were screened for their cytotoxic activity against MCF-7 breast cancer cell line and the percentage inhibition against VEGFR-2. Compounds 9, 20, 22 and 23, showed excellent VEGFR-2 inhibitory activity with IC50 ranging from 0.64 to 1.04 µm. Being the most potent, compound 9 was evaluated for its apoptotic inducer effect by studying the effect on caspase-3, it was found to increase its level. Compound 9 boosted the level of Bax and reduced the level of BCl2, compared to the control. Cell cycle analysis was conducted, compound 9 showed cell cycle arrest at G2/M phase. Moreover, mild cytotoxic effect (IC50 = 29.41 µm, respectively) in normal breast cells MCF-12 A, was observed when treated with the same compound. Finally, a molecular docking study was performed to investigate the possible binding interaction inside the active site of the VEGFR-2 enzyme.
Dynamic contrast-enhanced MRI of the microenvironment of pancreatic adenocarcinoma xenografts
Creators: name: Wegner, Catherine S.
name: Hauge, Anette
name: Jon-Vidar Gaustad
name: Andersen, Lise Mari K.
name: Simonsen, Trude G.
name: Kanthi Galappathi
name: Rofstad, Einar K.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with poor outcome. Resistance to treatment is associated with impaired vascularity, extensive hypoxia, and interstitial hypertension. In this study, the potential of dynamic contrast-enhanced (DCE)-MRI as a method for assessing the microvascular density (MVD), the fraction of hypoxic tissue, and the interstitial fluid pressure (IFP) of PDACs was investigated. Material and methods: Intramuscular BxPC-3, Capan-2, MIAPaCa-2, and Panc-1 PDAC xenografts were used as preclinical models of human PDACs. DCE-MRI with Gd-DOTA as contrast agent was conducted with a 7.05-T scanner, and the DCE-MRI series were analyzed voxelwise by using the Tofts pharmacokinetic model. Tumor MVD and hypoxia were measured in histological preparations by using pimonidazole as a hypoxia marker and CD31 as a marker of endothelial cells. IFP was measured with a Millar catheter. Results:Ktrans (the volume transfer constant of Gd-DOTA) increased with increasing MVD and decreased with increasing hypoxic fraction, but was not associated with IFP. Any association between ve (the fractional distribution volume of Gd-DOTA) and MVD, hypoxic fraction, or IFP could not be detected. Conclusions: This study shows that DCE-MRI is a useful modality for assessing important features of the microenvironment of PDAC xenografts and thus provides the basis for future preclinical and clinical DCE-MRI investigations of PDAC.
Additional file 3 of Chrysoeriol suppresses hyperproliferation of rheumatoid arthritis fibroblast-like synoviocytes and inhibits JAK2/STAT3 signaling
Creators: name: Wu, Jia-Ying
name: Chen, Ying-Jie
name: Fu, Xiu-Qiong
name: Li, Jun-Kui
name: Chou, Ji-Yao
name: Yin, Cheng-Le
name: Bai, Jing-Xuan
name: Wu, Ying
name: Wang, Xiao-Qi
name: Li, Amy Sze-man
name: Wong, Lut Yi
name: Yu, Zhi-Ling
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: Additional file 3. Original blot images of immunoblotting results in Fig. 2b. Representative images of cleaved caspase-3,cleaved caspase-9 and GAPDH are shown. Bands are shown on different films because of different exposure time
title: Zwiggi – die Federklemme
title: Didaktische Hinweise zur Fertigung der Federklemme Zwiggi
titleType: Subtitle
Creators: name: Penning, Isabelle
name: Gulich, Riccardo
name: Glugla, Markus
Publisher: name: Universität Potsdam
Year: 2024
Subjects: subject: 370 Bildung und Erziehung

description: Lehrkräfte sind mit Blick auf ihre heterogenen Lerngruppen im Technikunterricht darauf angewiesen, einen differenzierten Unterricht zu gestalten, der personelle, organisatorische und sachliche Ressourcen miteinbezieht. Bei Fertigungsaufgaben bietet sich daher der Einsatz von Vorrichtungen an, über die auf die unterschiedlichen Lernvoraussetzungen von Schüler:innen reagiert werden kann. So lassen sich die Anforderungen von Fertigungsaufgaben gezielt variieren.
Die vorliegende Publikation beschreibt die Federklemme „Zwiggi“, die beispielsweise zur Fixierung von Objekten in Fertigungsprozessen, wie dem Verleimen von zwei Komponenten, eingesetzt werden kann. Sie hat eine insgesamte Länge von 17 cm und eine Breite von 11 cm. Dabei beträgt die maximale Öffnungsdistanz ca. 5cm. „Zwiggi“ besteht aus zwei identischen Schenkeln und einem aus zwei Rundstäben gefertigten Gelenk. Gummiringe aus alten Fahrradschläuchen sorgen für das Schließen und einen entsprechenden Anpressdruck der Federklemme. Der Anpressdruck kann über die Menge und Durchmesser der Gummis angepasst werden, was ein Vorteil gegenüber den meisten handelsüblichen Federklemmen darstellt.
Die Dokumentationen umfasst neben den Fertigungsunterlagen kleinschrittige Bauanleitungen, die ggf. auch gemeinsam mit Schüler:innen umgesetzt werden können. Zudem enthalten sind beispielhafte Kostenrechnungen sowie Schablonen, die zur Erleichterung des Fertigungsprozesses verwendet werden können. Des Weiteren wird durch vereinzelt beigefügte interaktive technische Zeichnungen die Adaption der Vorrichtungen ermöglicht.
Syntheses and evaluation of multicaulin and miltirone-like compounds as antituberculosis agents
Creators: name: Burmaoğlu, Serdar
name: Seçinti, Hatice
name: Mozioğlu, Erkan
name: Gören, Ahmet C.
name: Altundaş, Ramazan
name: Seçen, Hasan
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology

description: Four multicaulin and miltirone-like phenanthrene derivatives were synthesised and evaluated as antituberculosis agents. The crucial step of the synthesis was Pschorr coupling of 4-(3-isopropyl-4-methoxyphenyl)-2-(2-aminophenyl)ethane (13) to give 2-isopropyl-3-methoxy-9,10-dihydrophenanthrene (9) and 4-isopropyl-3-methoxy-9,10-dihydrophenanthrene (9a). Compound 9 was converted to multicaulin and miltirone-like phenanthrene derivatives by further reactions. The best antituberculosis activity was exhibited by 2-isopropylphenanthrene-3-ol (11).
Additional file 1 of Recurrent colorectal liver metastasis patients could benefit from repeat hepatic resection
Creators: name: Liu, Wei
name: Liu, Jia-Ming
name: Wang, Kun
name: Wang, Hong-Wei
name: Xing, Bao-Cai
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1: Figure S1. Flowchart of the enrolled cohorts.
Design, synthesis and evaluation of 2-aryl benzoxazoles as promising hit for the A2A receptor
Creators: name: Duroux, Romain
name: Renault, Nicolas
name: Cuelho, Joana Esteves
name: Agouridas, Laurence
name: Blum, David
name: Lopes, Luisa V.
name: Melnyk, Patricia
name: Saïd Yous
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Inorganic Chemistry

description: The development of adenosine A2A receptor antagonists has received much interest in recent years for the treatment of neurodegenerative diseases. Based on docking studies, a new series of 2-arylbenzoxazoles has been identified as potential A2AR antagonists. Structure-affinity relationship was investigated in position 2, 5 and 6 of the benzoxazole heterocycle leading to compounds with a micromolar affinity towards the A2A receptor. Compound F1, with an affinity of 1 μm, presented good absorption, distribution, metabolism and excretion properties with an excellent aqueous solubility (184 μm) without being cytotoxic at 100 μm. This compound, along with low-molecular weight compound D1 (Ki = 10 μm), can be easily modulated and thus considered as relevant starting points for further hit-to-lead optimisation.
Berry anthocyanin content of Cabernet Sauvignon (Vitis vinifera L.) cultivated under rain-shelter systems with different coloured plastic films
Creators: name: Pengbao Shi
name: Zuo, Lili
name: Meiying Liu
name: Changzheng Song
name: Zhenwen Zhang
name: Jiangfei Meng
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Covering vineyards with rain-shelters is an effective viticulture practice to protect grapes from adverse environments, and the rain-shelter can influence radiometric properties, canopy microclimate, and grape berry quality. We investigated the effect of rain-shelter cultivation covered with different coloured plastic films on canopy microclimate and anthocyanins in the skins of Cabernet Sauvignon grape berries through comparison with open-field cultivation (control) of two vintages (2013 and 2014) in northern China. The results show that the highest average temperature and lowest relative humidity were presented by the grape canopies in the open-field cultivation, followed by the colourless, blue, purple, yellow, and red film. Higher infrared radiation was recorded in control plants. The content of sugar in the berries under rain-shelter cultivation (except colourless film in 2013) was significantly higher than that of the control. The concentrations of most anthocyanins were significantly decreased under the yellow and colourless films in the two vintages. The red and purple films increased the concentration of 3ʹ,5ʹ-substituted, methoxylated, and acylated anthocyanins in the grapes in both vintages. The results suggest that the application of such films may be useful for the production of high-quality wine grapes in warm temperate climates with dry winter and hot summer regions.
Additional file 4: of ANLN-induced EZH2 upregulation promotes pancreatic cancer progression by mediating miR-218-5p/LASP1 signaling axis
Creators: name: Wang, Anbin
name: Dai, Haisu
name: Gong, Yi
name: Zhang, Chengcheng
name: Shu, Junjie
name: Luo, Yuandeng
name: Jiang, Yan
name: Liu, Wei
name: Bie, Ping
Publisher: name: figshare
Year: 2019
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Virology

description: Table S4. GO terms representing cellular compartment. (DOCX 19 kb)
Supplementary Material for: Integrated High Throughput Analysis Identifies GSK3 as a Crucial Determinant of p53-Mediated Apoptosis in Lung Cancer Cells
Creators: name: Zhang, Y.
name: Zhu, C.
name: Sun, B.
name: Lv, J.
name: Liu, Z.
name: Liu, S.
name: Li, H.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Background/Aims: p53 dysfunction is frequently observed in lung cancer. Although restoring the tumour suppressor function of p53 is recently approved as a putative strategy for combating cancers, the lack of understanding of the molecular mechanism underlying p53-mediated lung cancer suppression has limited the application of p53-based therapies in lung cancer. Methods and Results: Using RNA sequencing, we determined the transcriptional profile of human non-small cell lung carcinoma A549 cells after treatment with two p53-activating chemical compounds, nutlin and RITA, which could induce A549 cell cycle arrest and apoptosis, respectively. Bioinformatics analysis of genome-wide gene expression data showed that distinct transcription profiles were induced by nutlin and RITA and 66 pathways were differentially regulated by these two compounds. However, only two of these pathways, 'Adherens junction' and 'Axon guidance', were found to be synthetic lethal with p53 re-activation, as determined via integrated analysis of genome-wide gene expression profile and short hairpin RNA (shRNA) screening. Further functional protein association analysis of significantly regulated genes associated with these two synthetic lethal pathways indicated that GSK3 played a key role in p53-mediated A549 cell apoptosis, and then gene function study was performed, which revealed that GSK3 inhibition promoted p53-mediated A549 cell apoptosis in a p53 post-translational activity-dependent manner. Conclusion: Our findings provide us with new insights regarding the mechanism by which p53 mediates A549 apoptosis and may cast light on the development of more efficient p53-based strategies for treating lung cancer.
Supplementary Material for: Identification and Characterization of Long Non-Coding RNAs in Osteogenic Differentiation of Human Adipose-Derived Stem Cells
Creators: name: Huang, G.
name: Kang, Y.
name: Huang, Z.
name: Zhang, Z.
name: Meng, F.
name: Chen, W.
name: Fu, M.
name: Liao, W.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Background/Aims: Long noncoding RNAs (lncRNAs) play important roles in stem cell differentiation. However, their role in osteogenesis of human adipose-derived stem cells (ASCs), a promising cell source for bone regeneration, remains unknown. Here, we investigated the expression profile and potential roles of lncRNAs in osteogenic differentiation of human ASCs. Methods: Human ASCs were induced to differentiate into osteoblasts in vitro, and the expression profiles of lncRNAs and mRNAs in undifferentiated and osteogenic differentiated ASCs were obtained by microarray. Bioinformatics analyses including subgroup analysis, gene ontology analysis, pathway analysis and co-expression network analysis were performed. The function of lncRNA H19 was determined by in vitro knockdown and overexpression. Quantitative reverse transcription polymerase chain reaction was utilized to examine the expression of selected genes. Results: We identified 1,460 upregulated and 1,112 downregulated lncRNAs in osteogenic differentiated human ASCs as compared with those of undifferentiated cells (Fold change ≥ 2.0, P < 0.05). Among these, 94 antisense lncRNAs, 85 enhancer-like lncRNAs and 160 lincRNAs were further recognized. We used 12 lncRNAs and 157 mRNAs to comprise a coding-non-coding gene expression network. Additionally, silencing of H19 caused a significantly increase in expression of osteogenesis-related genes, including ALPL and RUNX2, while a decrease was observed after H19 overexpression. Conclusion: This study revealed for the first time the global expression profile of lncRNAs involved in osteogenic differentiation of human ASCs and provided a foundation for future investigations of lncRNA regulation of human ASC osteogenesis.
New Kid on the (NFDI) Block: NFDI4BIOIMAGE  - A National Initiative for FAIR Data Management in Bioimaging and Bioimage Analysis
Creators: name: Wetzker, Cornelia
Publisher: name: Zenodo
Year: 2024

description: The poster introduces the consortium NFDI4BIOIMAGE with its central objectives, provides an overview of challenges in bioimage data handling, sharing and analysis and lists support options by the consortium through its data stewardship team.

It is part of the work of the German consortium NFDI4BIOIMAGE funded by the Deutsche Forschungsgemeinschaft (DFG grant number NFDI 46/1, project number 501864659) and has been presented at the conference FDM@Campus held in Göttingen September 23-25, 2024.