cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Snow topography on undeformed Arctic sea ice captured by an idealized "snow dune" model
Creators: name: Popović, Predrag
name: Finkel, Justin
name: Silber, Mary C.
name: Abbot, Dorian S.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Pattern Formation and Solitons (nlin.PS)
subject: Atmospheric and Oceanic Physics (physics.ao-ph)
subject: Geophysics (physics.geo-ph)
subject: FOS: Physical sciences

description: Our ability to predict the future of Arctic sea ice is limited by ice's sensitivity to detailed surface conditions such as the distribution of snow and melt ponds. Snow on top of the ice decreases ice's thermal conductivity, increases its reflectivity (albedo), and provides a source of meltwater for melt ponds during summer that decrease the ice's albedo. In this paper, we develop a simple model of pre-melt snow topography that accurately describes snow cover of flat, undeformed Arctic sea ice on several study sites for which data was available. The model considers a surface that is a sum of randomly sized and placed "snow dunes" represented as Gaussian mounds. This model generalizes the "void model" of Popović et al. (2018) and, as such, accurately describes the statistics of melt pond geometry. We test this model against detailed LiDAR measurements of the pre-melt snow topography. We show that the model snow-depth distribution is statistically indistinguishable from the measurements on flat ice, while small disagreement exists if the ice is deformed. We then use this model to determine analytic expressions for the conductive heat flux through the ice and for melt pond coverage evolution during an early stage of pond formation. We also formulate a criterion for ice to remain pond-free throughout the summer. Results from our model could be directly included in large-scale models, thereby improving our understanding of energy balance on sea ice and allowing for more reliable predictions of Arctic sea ice in a future climate.
title: Schwerer Verlauf eines Ramsay-Hunt-Syndroms bei einem professionellen Sänger
Creators: name: Cordier, Dahlia
name: Gergoe, Alena
name: Hackenberg, Berit
name: Läßig, Anne
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund Als Ramsay-Hunt-Syndrom (RHS) wird ein Zoster oticus in Verbindung mit akuter Fazialisparese sowie einer Assoziation mit vestibulocochleärer Dysfunktion bezeichnet, auch weitere Hirnnerven III–XII können betroffen sein. Das RHS umfasst die Symptome Otalgie, aurikuläre/retroaurikuläre[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Phoniatrisch-pädaudiologische Aspekte 2020
Photomanipulation of Minimal Synthetic Cells: Area Increase, Softening, and Interleaflet Coupling of Membrane Models Doped with Azobenzene-Lipid Photoswitches
Creators: name: Aleksanyan, Mina
name: Grafmüller, Andrea
name: Crea, Fucsia
name: Georgiev, Vasil N.
name: Yandrapalli, Naresh
name: Block, Stephan
name: Heberle, Joachim
name: Dimova, Rumiana
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: atomic force microscopy (AFM)
subject: azo-PC
subject: bending rigidity
subject: giant vesicles
subject: membrane capacitance
subject: molecular dynamics simulations
subject: photoswitchable lipids
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

description: Light can effectively interrogate biological systems in a reversible and physiologically compatible manner with high spatiotemporal precision. Understanding the biophysics of photo-induced processes in bio-systems is crucial for achieving relevant clinical applications. Employing membranes doped with the photolipid azobenzene-phosphatidylcholine (azo-PC), a holistic picture of light-triggered changes in membrane kinetics, morphology, and material properties obtained from correlative studies on cell-sized vesicles, Langmuir monolayers, supported lipid bilayers, and molecular dynamics simulations is provided. Light-induced membrane area increases as high as ≈25% and a ten-fold decrease in the membrane bending rigidity is observed upon trans-to-cis azo-PC isomerization associated with membrane leaflet coupling and molecular curvature changes. Vesicle electrodeformation measurements and atomic force microscopy reveal that trans azo-PC bilayers are thicker than palmitoyl-oleoyl phosphatidylcholine (POPC) bilayers but have higher specific membrane capacitance and dielectric constant suggesting an increased ability to store electric charges across the membrane. Lastly, incubating POPC vesicles with azo-PC solutions results in the insertion of azo-PC in the membrane enabling them to become photoresponsive. All these results demonstrate that light can be used to finely manipulate the shape, mechanical and electric properties of photolipid-doped minimal cell models, and liposomal drug carriers, thus, presenting a promising therapeutic alternative for the repair of cellular disorders.
An antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity
Creators: name: Ramesh, Niraja
name: Escher, Marc
name: Turrel, Oriane
name: Lützkendorf, Janine
name: Matkovic, Tanja
name: Liu, Fan
name: Sigrist, Stephan J.
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: plasticity
subject: active zone
subject: memory
subject: neurotransmission
subject: homeostasis
subject: presynaptic plasticity
subject: D. melanogaster
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: We still face fundamental gaps in understanding how molecular plastic changes of synapses intersect with circuit operation to define behavioral states. Here, we show that an antagonism between two conserved regulatory proteins, Spinophilin (Spn) and Syd-1, controls presynaptic long-term plasticity and the maintenance of olfactory memories in Drosophila. While Spn mutants could not trigger nanoscopic active zone remodeling under homeostatic challenge and failed to stably potentiate neurotransmitter release, concomitant reduction of Syd-1 rescued all these deficits. The Spn/Syd-1 antagonism converged on active zone close F-actin, and genetic or acute pharmacological depolymerization of F-actin rescued the Spn deficits by allowing access to synaptic vesicle release sites. Within the intrinsic mushroom body neurons, the Spn/Syd-1 antagonism specifically controlled olfactory memory stabilization but not initial learning. Thus, this evolutionarily conserved protein complex controls behaviorally relevant presynaptic long-term plasticity, also observed in the mammalian brain but still enigmatic concerning its molecular mechanisms and behavioral relevance.
Deoxygenative perfluoroalkylthiolation of carboxylic acids with benzothiazolium reagents
Creators: name: Haswell, Alex
name: Tironi, Matteo
name: Wang, Haoyue
name: Hopkinson, Matthew N.
Publisher: name: Freie Universität Berlin
Year: 2024
Subjects: subject: Fluorine
subject: Thioesters
subject: Benzothiazolium reagents
subject: Perfluoroalkyl groups
subject: Deoxygenative reactions
subject: Carboxylic acids
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

description: Deoxygenative perfluoroalkylthiolation reactions of readily available carboxylic acid derivatives have been developed using a series of 2-(perfluoroalkylthio)benzothiazolium (BT-SRF) reagents as convenient sources of perfluoroalkylthiolate anions. This method avoids pre-activation of the substrates and delivers rarely reported perfluoroalkyl thioesters featuring SRF groups up to C6F13. A survey of carboxylic acid substrates with the pentafluoroethylthiolating reagent BT-SC2F5 also revealed the generality of the approach as a method for accessing underexplored fluorinated compounds.
Regulation of cyclin E1 expression in human pluripotent stem cells and derived neural progeny
Creators: name: Varela, María Soledad Rodríguez
name: Mucci, Sofía
name: Agustín Videla Richardson, Guillermo
name: Hanon, Olivia Morris
name: Furmento, Verónica Alejandra
name: Gabriel Miriuka, Santiago
name: Emilio Sevlever, Gustavo
name: Elida Scassa, María
name: Romorini, Leonardo
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Human pluripotent stem cells (hPSCs), including embryonic and induced pluripotent stem cells (hESCs and hiPSCs) show unique cell cycle characteristics, such as a short doubling time due to an abbreviated G1 phase. Whether or not the core cell cycle machinery directly regulates the stemness and/or the differentiation potential of hPSCs remains to be determined. To date, several scenarios describing the atypical cell cycle of hPSCs have been suggested, and therefore there is still controversy over how cyclins, master regulators of the cell cycle, are expressed and regulated. Furthermore, the cell cycle profile and the expression pattern of major cyclins in hESCs-derived neuroprogenitors (NP) have not been studied yet. Therefore, herein we characterized the expression pattern of major cyclins in hPSCs and NP. We determined that all studied cyclins mRNA expression levels fluctuate along cell cycle. Particularly, after a thorough analysis of synchronized cell populations, we observed that cyclin E1 mRNA levels increased sharply in G1/S concomitantly with cyclin E1 protein accumulation in hPSCs and NP. Additionally, we demonstrated that cyclin E1 mRNA expression levels involves the activation of MEK/ERK pathway and the transcription factors c-Myc and E2Fs in hPSCs. Lastly, our results reveal that proteasome mediates the marked down-regulation (degradation) of cyclin E1 protein observed in G2/M by a mechanism that requires a functional CDK2 but not GSK3β activity. Abbreviations: hPSCs: human pluripotent stem cells; hESCs: human embryonic stem cells; hiPSCs: human induced pluripotent stem cells; NP: neuroprogenitors; HF: human foreskin fibroblasts; MEFs: mouse embryonic fibroblasts; iMEFs: irradiated mouse embryonic fibroblasts; CDKs: cyclindependent kinases; CKIs: CDK inhibitors; CNS: central nervous system; Oct-4: Octamer-4; EB: embryoid body; AFP: Alpha-fetoprotein; cTnT: Cardiac Troponin T; MAP-2: microtubule-associated protein; TUJ-1: neuron-specific class III β-tubulin; bFGF: basic fibroblastic growth factor; PI3K: Phosphoinositide 3-kinase; KSR: knock out serum replacement; CM: iMEF conditioned medium; E8: Essential E8 medium
title: Quantifizierung der zeitveränderlichen Stimmlippenmorphologie mittels Laryngovibrogrammen
Creators: name: Fehling, Mona Kirstin
name: Schuster, Maria Elke
name: Linxweiler, Maximilian
name: Lohscheller, Jörg
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung Die endoskopische Hochgeschwindigkeits-(HG-)Videolaryngoskopie erlaubt eine präzise Erfassung der Stimmlippen-(SL-)Dynamik in Echtzeit. In den vergangenen Jahren wurden zahlreiche Ansätze zur Quantifizierung des SL-Schwingungsverhaltens aus HG-Aufnahmen vorgestellt, welche zum[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Phoniatrisch-pädaudiologische Aspekte 2020
Ring-opening terpolymerisation of phthalic thioanhydride with carbon dioxide and epoxides
Creators: name: Stühler, Merlin R.
name: Gallizioli, Cesare
name: Rupf, Susanne M.
name: Plajer, Alex J.
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: ring-opening terpolymerisation
subject: phthalic thioanhydride
subject: carbon dioxide
subject: epoxides
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

description: In seeking to expand the portfolio of accessible polymer structures from CO2 waste, we report the ring-opening terpolymerisation (ROTERP) of phthalic thioanhydride with CO2 and epoxides, forming statistical poly(ester-thioester-carbonates) by employing heterobimetallic catalysts. Both metal choice and ligand chemistry modulate the amount of CO2 incorporated into the polymer microstructure. Terpolymerisation occurs when maintaining polymerisation rates of the faster parent ring-opening copolymerisation and this finding led us to develop the formation of CO2-derived terpolymers with butylene oxide at low CO2 pressure under bicomponent catalysis. Tetrapolymerisation with added phthalic anhydride leads to the preferential polymerisation of phthalic anhydride before the polymerisation of sulfur derivatives with CO2 and epoxides. Finally, we show that the presence of sulfur-containing thioester links leads to polymers with degradability benefits compared to those from all-oxygen derivatives.
title: Defektverschluss nach tumorchirurgischer Resektion im oberen Aerodigestivtrakt durch polymere Implantatmaterialien – Fiktion oder Realität?
Creators: name: Rickert, Dorothee
name: Steinhart, Helmut
name: Lendlein, Andreas
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund Die Regenerative Medizin wird als vielversprechender Bereich der modernen Biomedizin angesehen. Die Verwendung von polymeren Implantatmaterialien zum Defektverschluss nach tumorchirurgischer Resektion im Bereich des oberen Aerodigestivtraktes anstelle von Hautmuskellappen würde eine[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Phoniatrisch-pädaudiologische Aspekte 2020
Cramér moderate deviations for a supercritical Galton-Watson process
Creators: name: Doukhan, Paul
name: Fan, Xiequan
name: Gao, Zhi-Qiang
Publisher: name: arXiv
Year: 2021
Subjects: subject: Probability (math.PR)
subject: Statistics Theory (math.ST)
subject: FOS: Mathematics
subject: 60G42, 60F10, 60E15, 62F03

description: Let $(Z_n)_{n\geq0}$ be a supercritical Galton-Watson process. The Lotka-Nagaev estimator $Z_{n+1}/Z_n$ is a common estimator for the offspring mean.In this paper, we establish some Cramér moderate deviation results for the Lotka-Nagaev estimator via a martingale method. Applications to construction of confidence intervals are also given.
Additional file 3 of An age-group analysis on the efficacy of chemotherapy in older adult patients with metastatic biliary tract cancer: a Japanese cancer registry cohort study
Creators: name: Hirao, Takeru
name: Ikezawa, Kenji
name: Morishima, Toshitaka
name: Daiku, Kazuma
name: Seiki, Yusuke
name: Watsuji, Ko
name: Kawamoto, Yasuharu
name: Higashi, Sena
name: Urabe, Makiko
name: Kai, Yugo
name: Takada, Ryoji
name: Yamai, Takuo
name: Mukai, Kaori
name: Nakabori, Tasuku
name: Uehara, Hiroyuki
name: Miyashiro, Isao
name: Ohkawa, Kazuyoshi
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: Supplementary Material 3
Creating Inclusive Spaces for Students in Higher Education with Caregiving Responsibilities
Creators: name: Moreau, Marie-Pierre
Publisher: name: Anglia Ruskin University
Year: 2019
Subjects: subject: Education
subject: 130103 Higher Education
subject: FOS: Educational sciences
subject: Sociology
subject: FOS: Sociology

description: Policy Briefing:Creating Inclusive Spaces for Students in Higher Education with Caregiving Responsibilities
title: Aphagie bei Pharynxnekrose als Spätfolge nach Radiochemotherapie eines Carcinoms der Pharynxhinterwand
Creators: name: Lodes, Sophia
name: Steinbichler, Theresa
name: Gassner, Eva-Maria
name: Zorowka, Patrick
name: Galvan, Oliver
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund Schluckstörungen sind häufige und z.T. schwerwiegende Folgen einer onkologischen Behandlung im Kopf-Hals-Bereich und stellen einen Risikofaktor für Malnutrition dar. Insbesondere Tumore der Mundhöhle und des Oropharynx sind assoziiert mit einer schlechteren Schluckfunktion.[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Phoniatrisch-pädaudiologische Aspekte 2020
Underwater Thematic Services Assessment Report
Creators: name: Quintana, Josep
name: Campos, Ricard
name: Karantzalos, Konstantinos
name: Wintersteller, Paul
Publisher: name: Zenodo
Year: 2022
Subjects: Underwater
Bathymetry
Seabed classification

description: This document is a final overall report on the assessment and evaluation of the NEANIAS UNDERWATER services mainly from user perspective, but also including their technical assessment. Assessment and evaluations processes have been performed for each of the UNDERWATER services release cycles (from release #1 to the latest release #3) involving users internal to the NEANIAS consortium as well as external to the consortium, mainly belonging to academic and research institutes. Also, user feedbacks have been collected and, finally, a technical assessment has been performed thanks to template checklists made available by WP7.
Extragalactic star-forming galaxies with hypernovae and supernovae as high-energy neutrino and gamma-ray sources: the case of the 10 TeV neutrino data
Creators: name: Senno, Nicholas
name: Mészáros, Peter
name: Murase, Kohta
name: Baerwald, Philipp
name: Rees, Martin J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In light of the latest IceCube data, we discuss the implications of the cosmic ray energy input from hypernovae and supernovae into the Universe, and their propagation in the hosting galaxy and galaxy clusters or groups. The magnetic confinement in these environments may lead to efficient $pp$ collisions, resulting in a diffuse neutrino spectrum extending from PeV down to 10 TeV energies, with a spectrum and flux level compatible with that recently reported by IceCube. If the diffuse 10 TeV neutrino background largely comes from such the CR reservoirs, the corresponding diffuse gamma-ray background should be compatible with the recent \textit{Fermi} data. In this scenario, the CR energy input from hypernovae should be dominant over that of supernovae, implying that the starburst scenario does not work if the supernova energy budget is a factor of two larger than the hypernova energy budget. Thus, this strong case scenario can be supported or ruled out in near future.
description: 9 pages, 4 figures, ApJ, in press
Mitochondria-targeted antioxidant SkQ1 suppresses fibrosarcoma and rhabdomyosarcoma tumour cell growth
Creators: name: Titova, Ekaterina
name: Shagieva, Galina
name: Ivanova, Olga
name: Domnina, Lidiya
name: Domninskaya, Maria
name: Strelkova, Olga
name: Khromova, Natalya
name: Kopnin, Pavel
name: Chernyak, Boris
name: Skulachev, Vladimir
name: Dugina, Vera
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: Plant Biology

description: Mitochondria are important regulators of tumour growth and progression due to their specific role in cancer metabolism and modulation of apoptotic pathways. In this paper we describe that mitochondria-targeted antioxidant SkQ1 designed as a conjugate of decyl-triphenylphosphonium cation (TPP+) with plastoquinone, suppressed the growth of fibrosarcoma HT1080 and rhabdomyosarcoma RD tumour cells in culture and tumour growth of RD in xenograft nude mouse model. Under the same conditions, no detrimental effect of SkQ1 on cell growth of primary human subcutaneous fibroblasts was observed. The tumour growth suppression was shown to be a result of the antioxidant action of low nanomolar concentrations of SkQ1. We have revealed significant prolongation of mitosis induced by SkQ1 in both tumour cell cultures. Prolonged mitosis and apoptosis could be responsible for growth suppression after SkQ1 treatment in RD cells. Growth suppression in HT1080 cells was accompanied by the delay of telophase and cytokinesis, followed by multinuclear cells formation. The effects of SkQ1 on the cell cycle were proved to be at least partially mediated by inactivation of Aurora family kinases. Abbreviations: TPP+: Triphenylphosphonium cation; ROS: Reactive oxygen species; mtROS: Mitochondrial reactive oxygen species; NAC: N-acetyl-L-cysteine; DCFH-DA: Dichlorodihydrofluorescein diacetate; APC: Anaphase promoting complex; ABPs: Actin-binding proteins; DMEM: Dulbecco’s modified Eagle media; SDS: sodium dodecyl sulfate; HEPES: 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid
Creating Inclusive Spaces for Academic Staff with Caregiving Responsibilities
Creators: name: Moreau, Marie-Pierre
Publisher: name: Anglia Ruskin University
Year: 2019
Subjects: subject: Education
subject: 130103 Higher Education
subject: FOS: Educational sciences
subject: Sociology
subject: FOS: Sociology

description: Policy Briefing: Creating Inclusive Spaces for Academic Staff with Caregiving Responsibilities
title: Die PhonoSens-Behandlung phonologischer Aussprachestörungen bei Kindern. Eine randomisiert-kontrollierte Wirksamkeitsstudie
Creators: name: Siemons-Lühring, Denise
name: Neumann, Katrin
name: Euler, Harald
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund Die Wirksamkeit des Behandlungsprogramms PhonoSens für funktionelle Aussprachestörungen von Kindern im Praxisalltag wird in einer randomisiert-kontrollierten Studie evaluiert (Siemons-Lühring et al., under review). PhonoSens verwendet einen integrierten Ansatz aus kategorialer[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Phoniatrisch-pädaudiologische Aspekte 2020
Microtubules play an essential role in the survival of primary acute lymphoblastic leukemia cells advancing through G1 phase
Creators: name: Delgado, Magdalena
name: C. Chambers, Timothy
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: We recently reported that primary acute lymphoblastic leukemia (ALL) cells are susceptible to the microtubule depolymerizing agent vincristine (VCR) in G1 phase. This finding prompted testing another G1 phase-active compound, palbociclib (PCB), a highly selective inhibitor of cyclin-dependent kinases 4/6 (CDK4/6), alone and in combination with VCR. PCB used alone caused G1 arrest in ALL cells with no effect on cell viability, and similar results were obtained for the retinoblastoma (RB)-proficient T98G glioblastoma cell line. In contrast, HeLa cells failed to arrest in the presence of PCB, consistent with their lack of dependence on the CDK4/6-RB pathway. When ALL cells were pretreated with PCB, they became refractory to death in G1 phase induced by VCR treatment, whereas HeLa cells retained VCR sensitivity after PCB pretreatment. Immunofluorescence microscopy showed that PCB did not disrupt the microtubule network nor prevent VCR from doing so. Furthermore, ALL cells pretreated with PCB retained susceptibility to the Bcl-2/Bcl-xL inhibitor ABT-263, indicating that downstream apoptotic signaling was unaffected. When released from PCB-enforced arrest, ALL cells reinitiated cycling and regained sensitivity to VCR. ALL cells treated with cycloheximide also arrested in G1 phase and became insensitive to VCR, independently reinforcing conclusions derived from PCB-imposed arrest. Thus, primary ALL cells advancing through G1 phase are strictly dependent on functional microtubules for survival whereas microtubules are dispensable for G1-arrested cells. These findings provide novel insight into interphase microtubule function and, from a therapy standpoint, strongly caution against combining microtubule targeting agents and CDK4/6 inhibitors for ALL.
Transport-majorization to analytic and geometric inequalities
Creators: name: Melbourne, James
name: Roberto, Cyril
Publisher: name: arXiv
Year: 2021
Subjects: subject: Functional Analysis (math.FA)
subject: Probability (math.PR)
subject: FOS: Mathematics

description: We introduce a transport-majorization argument that establishes a majorization in the convex order between two densities, based on control of the gradient of a transportation map between them. As applications, we give elementary derivations of some delicate Fourier analytic inequalities, which in turn yield geometric "slicing-inequalities" in both continuous and discrete settings. As a further consequence of our investigation we prove that any strongly log-concave probability density majorizes the Gaussian density and thus the Gaussian density maximizes the Rényi and Tsallis entropies of all orders among all strongly log-concave densities.
description: 26 pages, online at Journal of Functional Analysis
title: Entwicklung von auditiven Verarbeitungs- und Wahrnehmungsleistungen bei Grundschulkindern mit und ohne AVWS
Creators: name: Nickisch, Andreas
name: Nickisch, Leonie
name: Kiese-Himmel, Christiane
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund Die Reifung des zentral-auditorischen Systems kann bei hörgesunden Kindern mit objektiven Untersuchungsverfahren belegt werden [ref:1], [ref:6]; in subjektiven Tests ist dies mit zunehmendem Lebensalter bzw. bei Schulkindern mit ansteigender Schuljahresstufe an[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Phoniatrisch-pädaudiologische Aspekte 2020
Numerical simulations of the magnetorotational instability in protoneutron stars: I. Influence of buoyancy
Creators: name: Guilet, Jerome
name: Mueller, Ewald
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The magneto-rotational instability (MRI) is considered to be a promising mechanism to amplify the magnetic field in fast rotating protoneutron stars. In contrast to accretion disks, radial buoyancy driven by entropy and lepton fraction gradients is expected to have a dynamical role as important as rotation and shear. We investigate the poorly known impact of buoyancy on the non-linear phase of the MRI, by means of three dimensional numerical simulations of a local model in the equatorial plane of a protoneutron star. The use of the Boussinesq approximation allows us to utilise a shearing box model with clean shearing periodic boundary conditions, while taking into account the buoyancy driven by radial entropy and composition gradients. We find significantly stronger turbulence and magnetic fields in buoyantly unstable flows. On the other hand, buoyancy has only a limited impact on the strength of turbulence and magnetic field amplification for buoyantly stable flows in the presence of a realistic thermal diffusion. The properties of the turbulence are, however, significantly affected in the latter case. In particular, the toroidal components of the magnetic field and of the velocity become even more dominant with respect to the poloidal ones. Furthermore, we observed in the regime of stable buoyancy the formation of long lived coherent structures such as channel flows and zonal flows. Overall, our results support the ability of the MRI to amplify the magnetic field significantly even in stably stratified regions of protoneutron stars.
description: 22 pages, 15 figures, accepted for publication in MNRAS
Ultrafast and terahertz spintronics: Guest editorial
Creators: name: Kampfrath, Tobias
name: Kirilyuk, Andrei
name: Mangin, Stéphane
name: Sharma, Sangeeta
name: Weinelt, Martin
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: Spin-based electronics
subject: spintronics
subject: ultrafast
subject: terahertz
subject: 500 Naturwissenschaften und Mathematik::530 Physik::530 Physik

description: Spin-based electronics (spintronics) aims at extending electronic functionalities, which rely on the electron charge as information carrier, by the spin of the electron. To make spintronics competitive and compatible with other information carriers like photons and electrons, their speed needs to be pushed to femtosecond time scales and, thus, terahertz frequencies. In ultrafast and terahertz spintronics, femtosecond optical and terahertz electromagnetic pulses are used to induce spin torque and spin transport and to monitor the subsequent time evolution. The two approaches, sometimes referred to as femto-magnetism and terahertz magnetism, have provided new, surprising, and relevant insight as well as applications for spintronics. Examples include the ultrafast optical switching of magnetic order and the generation of broadband terahertz electromagnetic fields. This APL Special Topic Collection is dedicated to provide a platform for the newest developments and future trends in the very active, dynamic, and exciting research field of ultrafast and terahertz spintronics.
title: Handlungsempfehlungen für das Universitätsklinikum Münster zur Prävention und Behandlung der Mangelernährung bei Säuglingen und Kindern mit angeborenem Herzfehler; systematische Literaturrecherche und Erfassung der Ernährungstherapie in ausgewählten Herzzentren
Creators: name: Kolte, Sonja
Publisher: name: FH Münster
Year: 2017
Subjects: subject: 610 Medizin und Gesundheit

description: Mangelernährung ist bei Säuglingen und Kindern mit angeborenen Herzfehlern ein häufiges Phänomen. Das Ziel dieser Arbeit ist die Erstellung von Handlungsempfehlungen für die Prävention und Behandlung der Mangelernährung bei Säuglingen und Kindern mit angeborenen Herzfehlern über die Analyse der prä- und postoperativen Ernährungsstrategien, Identifikation von Barrieren und die Darstellung der Ernährungstherapie in der Praxis. Dazu wurden eine systematische Literaturrecherche und Experteninterviews mit Herzzentren aus Deutschland durchgeführt. Prä- und postoperativ wird zur Vermeidung einer Mangelernährung eine erhöhte Kalorienzufuhr verwendet. Es gibt vielfältige Barrieren, die eine ausreichende Nährstoffzufuhr erschweren wie z.B. Trinkschwäche. Eine Ernährungsunterstützung mit hochkalorischer Nahrung vor der Operation verbessert die postoperativen Outcomes und den Ernährungsstatus. Nach der Operation ist der Nahrungsaufbau früh zu beginnen. Eine enterale oder orale Ernährung ist der parenteralen Ernährung vorzuziehen. Zu dem perioperativen Ernährungsmanagement gehören die regelmäßige Erfassung des Ernährungsstatus, die Zusammenarbeit im multidisziplinären Team und ein standardisiertes Monitoring. Eine individuelle Ernährungsstrategie wird angewendet. Aus den Ergebnissen ist zu folgern, dass die grundlegende Maßnahme zur Prävention und Behandlung der Mangelernährung bei angeborenen Herzfehlern eine höhere Kalorienzufuhr ist. Damit die Energieaufnahme adäquat ist, müssen die Ursachen und Barrieren aufgedeckt und behandelt werden. Eine individuelle Betreuung ist für eine bedarfsdeckende Ernährung notwendig. Eine erhöhte präoperative Kalorienzufuhr und ein früher Nahrungsaufbau nach der Operation vermeidet die Entstehung hoher Nährstoffdefizite. Die Vorbereitung der Nachsorge und eine weitere Überwachung des Wachstums sind wichtig für die Erhaltung eines guten Ernährungsstatus der Kinder.
Duality,Hidden Symmetry and Dynamic Isomerism in 2D Hinge Structures
Creators: name: Lei, Qun-Li
name: Tang, Feng
name: Hu, Ji-Dong
name: Ma, Yu-qiang
name: Ni, Ran
Publisher: name: arXiv
Year: 2021
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: Recently, a new type of duality was reported in some deformable mechanical networks which exhibit Kramers-like degeneracy in phononic spectrum at the self-dual point. In this work, we clarify the origin of this duality and propose a design principle of 2D self-dual structures with arbitrary complexity. We find that this duality originates from the (PCI) symmetry of the hinge, which belongs to a more general end-fixed scaling transformation. This symmetry gives the structure an extra degree of freedom without modifying its dynamics. This results in , i.e., dissimilar 2D mechanical structures, either periodic or aperiodic, having identical dynamic modes, based on which we demonstrate a new type of wave-guide without reflection or loss. Moreover, the PCI symmetry allows us to design various 2D periodic isostatic networks with hinge duality. At last, by further studying a 2D non-mechanical magnonic system, we show that the duality and the associated hidden symmetry should exist in a broad range of Hamiltonian systems.
description: 6 pages, 4 figures
Hot-Jupiter Inflation due to Deep Energy Deposition
Creators: name: Ginzburg, Sivan
name: Sari, Re'em
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Some extrasolar giant planets in close orbits---"hot Jupiters"---exhibit larger radii than that of a passively cooling planet. The extreme irradiation $L_{\rm eq}$ these hot Jupiters receive from their close in stars creates a thick isothermal layer in their envelopes, which slows down their convective cooling, allowing them to retain their inflated size for longer. This is yet insufficient to explain the observed sizes of the most inflated planets. Some models invoke an additional power source, deposited deep in the planet's envelope. Here we present an analytical model for the cooling of such irradiated, and internally heated gas giants. We show that a power source $L_{\rm dep}$, deposited at an optical depth $τ_{\rm dep}$, creates an exterior convective region, between optical depths $L_{\rm eq}/L_{\rm dep}$ and $τ_{\rm dep}$, beyond which a thicker isothermal layer exists, which in extreme cases may extend to the center of the planet. This convective layer, which occurs only for $L_{\rm dep}τ_{\rm dep}>L_{\rm eq}$, further delays the cooling of the planet. Such a planet is equivalent to a planet irradiated with $L_{\rm eq}\left(1+L_{\rm dep}τ_{\rm dep}/L_{\rm eq}\right)^β$, where $β\approx 0.35$ is an effective power-law index describing the radiative energy density as function of the optical depth for a convective planet $U\proptoτ^β$. Our simple analytical model reproduces the main trends found in previous numerical works, and provides an intuitive understanding. We derive scaling laws for the cooling rate of the planet, its central temperature, and radius. These scaling laws can be used to estimate the effects of tidal or Ohmic dissipation, wind shocks, or any other mechanism involving energy deposition, on sizes of hot Jupiters.
description: Consistent with published version
Comparative assessment of heavy metal contamination of abandoned and active dumpsite of Osun waste management, Ejigbo Road, Osogbo, Osun State, Nigeria.
Creators: name: Afolabi, Fatai
name: Adeyinka, Gbadebo Clement
name: Ajibola, Olaide Olawunmi
name: Bakare, Babatunde Femi
Publisher: name: Mangosuthu University of Technology (MUT)
Year: 2023
Subjects: Other chemical sciences not elsewhere classified
Conservation and biodiversity

description: This study conducts a comparative assessment of two dumpsites (abandoned and active dumpsite) around Osogbo metropolis Osun State Nigeria. Ten selected heavy metals(HMs)such as arsenic, copper, cobalt, cadmium, chromium, iron, nickel, manganese, lead and zinc were determined. The soil samples were collected, at strategic points to revealed variation in samples. The concentrations of HMs were quantitatively determined using atomic absorption spectroscopy. The resultsindicated that all the HMs determined were found between below detection limit (bdl) to 0.611 mg/kg and bdl –0.880 mg/kg for abandoned and active dumpsites, respectively. The concentration factor and geo-accumulation intensity revealed no contamination to strong contamination and from uncontaminated to strong contamina?tion intensity, respectively. The concentrations for some of the HMs were below the tolerable recommendation level by National Environmental Standards and Regulation Enforcement Agency and Food and Agriculture Organization/World Health Organization in soil samples. This study recommends periodic monitoring and that possi?ble decontamination of the dumpsite are crucial because these dump?sites were currently in use for crops cultivation such as maize, vegetable bananas, and some other arable plants. Also, HM concentra?tions in crops should be investigated and monitored at these dump?sites regularly in order to avert detrimental effects of HM pollution, which could manifest many years after exposure, as they are recalci?trant in the environment
title: Welche Hör- und Sprachbefunde verbergen sich hinter der Verdachtsdiagnose AVS?
Creators: name: Kruse, Dennis
name: Häge, Andrea
name: Maier, Cornelia
name: Reiter, Rudolf
name: Mack, Imke
name: Hoffmann, Thomas
name: Brosch, Sibylle
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund Die Häufigkeit und Symptomzusammensetzung von Kindern mit dem Verdacht auf eine auditive Verarbeitungsstörung sind nach wie vor unklar. Material und Methoden In der vorliegenden Arbeit wurden 106 Kinder (5–14 Jahre) mit der Überweisungsdiagnose „auditive[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Phoniatrisch-pädaudiologische Aspekte 2020
title: Registrierung einer Veränderung des Richtungshörens durch den ERKI-Test der Schallrichtungswahrnehmung nach Versorgung unilateral schwerhöriger Patienten mit Hörhilfen
Creators: name: Schmidt, Florian
name: Bruchhage, Karl-Ludwig
name: Schönweiler, Rainer
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund Einseitiger Hörverlust vermindert die Fähigkeit, Schallrichtungen zu erkennen (Richtungshören), da die Lokalisation von Schallquellen zum großen Teil auf der Beurteilung der auf beiden Ohren wahrgenommenen Pegelunterschiede beruht. Durch Hörversorgungen werden[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Phoniatrisch-pädaudiologische Aspekte 2020
Combined optical and electrical characterisation of minority carrier lifetime in solar cells
Creators: name: Tsai, Vincent
Publisher: name: Loughborough University
Year: 2019
Subjects: subject: 91399 Mechanical Engineering not elsewhere classified
subject: FOS: Mechanical engineering

description: This thesis presents a novel method to quantify the localised carrier collection efficiency of thin film solar cells by integrating a theoretical model with data from a newly developed combined measurement system capable of measuring spectrally-resolved photoluminescence (PL), time-resolved photoluminescence (TRPL) and transient photocurrent decay (TPCD) at the same spot on the solar cell. This combined measurement approach allows for the identification and further understanding of the limiting factors in the carrier collection efficiency of solar cells. [Continues.]
Additional file 1 of DNA hypermethylation driven by DNMT1 and DNMT3A favors tumor immune escape contributing to the aggressiveness of adrenocortical carcinoma
Creators: name: Kerdivel, Gwenneg
name: Amrouche, Floriane
name: Calmejane, Marie-Ange
name: Carallis, Floriane
name: Hamroune, Juliette
name: Hantel, Constanze
name: Bertherat, Jérôme
name: Assié, Guillaume
name: Boeva, Valentina
Publisher: name: figshare
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Additional file 1: Fig. S1. related to content in Fig. 1: DNMT1 and DNMT3A expression levels are upregulated in high CIMP ACC and are associated with poor clinical outcome. (a) Expression levels of DNMT1, DNMT3A, DNMT3B, TET1, TET2 and TET3 in the ENSAT patients exhibiting lCIMP (n = 20), iCIMP (n = 14) and hCIMP (n = 6) (two-sided t test, ***p < 0.005). (b) Kaplan–Meier estimates of overall survival for ACC patients, as a function of DNMT1 or DNMT3A. Fig. S2 related to content of Fig. 2: DNMT1 and DNMT3A expression is associated with high proliferation. Correlation between DNMT1 and DNMT3A expression and cell proliferation in the ENSAT patients. hCIMP (n = 6) samples are represented in red, iCIMP (n = 14) in orange and lCIMP (n = 20) in blue. Patients for whom the CIMP status was not defined are represented in gray. Fig. S3 related to content of Table 1: Gene Set Enrichment Analysis on TCGA datasets comparing hCIMP and lCIMP samples. (a) Representative example of gene sets enriched in hCIMP. (b) Representative example of gene sets enriched in lCIMP. Fig. S4, related to content of Fig. 3: CIMP in ACC is characterized by lower abundance of tumor-infiltrating immune cells Relative abundance of tumor-infiltrating immune and non-immune stromal cell populations, computed using MCP-counter, in lCIMP (n = 20), iCIMP (n = 14) and hCIMP (n = 6) samples from the ENSAT dataset. Comparison of relative abundances of each population using Kruskal–Wallis test followed by Dunn's test with Benjamini–Hochberg corrections. Fig. S5 related to content of Fig. 4: Impact of demethylating agent on cell proliferation in ACC cell lines. Effect of a 6-day treatment with the DNA methylation inhibitor 5-azacytidine (AZA) at 1, 5, or 10 µM in the H295R (n = 4), MUC1 (n = 5) cell lines and the non-tumor HUVEC cell line (n = 5). Cell growth was estimated by neutral red proliferation assay. p values of the Kruskal–Wallis test and Dunn’s test for stochastic dominance are reported: *p value < 0.05; **p value < 0.01; ***p value < 0.005. Fig. S6 related to content of Fig. 4: Gene pathways differentially active in H295R compared to MUC-1 cells due to DNA hypermethylation. Pathway enrichment analysis on genes that exhibit a significantly hypermethylated DMR in their promoter and significantly lower expression in H295R than in MUC-1 cells. Pathways related to the immune response are highlighted in red.
title: Bedeutung der humangenetischen Hördiagnostik bei geringgradigen kindlichen Schwerhörigkeiten am Beispiel des Schwerhörigkeit-Infertilitäts-Syndroms
Creators: name: Hackenberg, Berit
name: Martin, Evgenia
name: Bartsch, Oliver
name: Läßig, Anne K.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund Mindestens 54% der kongenitalen Schallempfindungsschwerhörigkeiten sind genetisch bedingt [ref:1]. Die Bedeutung der humangenetischen Hördiagnostik bei geringgradigen kindlichen Schwerhörigkeiten wird jedoch unterschätzt, so dass diese teilweise erst[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Phoniatrisch-pädaudiologische Aspekte 2020
Brace blocks from bilinear maps and liftings of endomorphisms
Creators: name: Caranti, A.
name: Stefanello, L.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Group Theory (math.GR)
subject: FOS: Mathematics
subject: 20B05 20D45 20N99 08A35 16T25

description: We extend two constructions of Alan Koch, exhibiting methods to construct brace blocks, that is, families of group operations on a set $G$ such that any two of them induce a skew brace structure on $G$. We construct these operations by using bilinear maps and liftings of endomorphisms of quotient groups with respect to a central subgroup. We provide several examples of the construction, showing that there are brace blocks which consist of distinct operations of any given cardinality. One of the examples we give yields an answer to a question of Cornelius Greither. This example exhibits a sequence of distinct operations on the $p$-adic Heisenberg group $(G, \cdot)$ such that any two operations give a skew brace structure on $G$ and the sequence of operations converges to the original operation "$\cdot$".
description: 19 pages
A porous-media model for reactive fluid-rock interaction in a dehydrating rock
Creators: name: Zafferi, Andrea
name: Huber, Konstantin
name: Peschka, Dirk
name: Vrijmoed, Johannes
name: John, Timm
name: Thomas, Marita
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: fluid-rock
subject: dehydrating rock
subject: General Equations of Non-Equilibrium Reversible-Irreversible Coupling
subject: GENERIC
subject: 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::551 Geologie, Hydrologie, Meteorologie

description: We study the General Equations of Non-Equilibrium Reversible–Irreversible Coupling (GENERIC) structure of models for reactive two-phase flows and their connection to a porous-media model for a reactive fluid–rock interaction used in geosciences. For this, we discuss the equilibration of fast dissipative processes in the GENERIC framework. Mathematical properties of the porous-media model and first results on its mathematical analysis are provided. The mathematical assumptions imposed for the analysis are critically validated with the thermodynamical rock datasets.
Testing the Universality of Free Fall using correlated $^{39}$K -- $^{87}$Rb interferometers
Creators: name: Barrett, Brynle
name: Condon, Gabriel
name: Chichet, Laure
name: Antoni-Micollier, Laura
name: Arguel, Romain
name: Rabault, Martin
name: Pelluet, Celia
name: Jarlaud, Vincent
name: Landragin, Arnaud
name: Bouyer, Philippe
name: Battelier, Baptiste
Publisher: name: arXiv
Year: 2021
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We demonstrate how simultaneously-operated $^{39}$K -- $^{87}$Rb interferometers exhibiting a high level of correlation can be used to make competitive tests of the university of free fall. This work provides an overview of our experimental apparatus and data analysis procedure, including a detailed study of systematic effects. With a total interrogation time of $2T = 40$ ms in a compact apparatus, we reach a statistical uncertainty on the measurement of the Eötvös parameter of $7.8 \times 10^{-8}$ after $2.4 \times 10^4$ s of integration. The main limitations to our measurement arise from a combination of wavefront aberrations, the quadratic Zeeman effect in $^{39}$K, parasitic interferometers in $^{87}$Rb, and the velocity sensitivity of our detection system. These systematic errors limit the accuracy of our measurement to $η= 0.9(1.6) \times 10^{-6}$. We discuss prospects for improvements using ultracold atoms at extended interrogation times.
title: Entwicklung der Lokalisationsfähigkeit bei bimodal versorgten Patienten währen der CI-Rehabilitation
Creators: name: Ludwig, Alexandra
name: Hammel, Sabine
name: Fuchs, Michael
name: Meuret, Sylvia
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund Die aktuelle Studie untersucht die Veränderung der Lokalisationsfähigkeit nicht-sprachlicher, akustischer Signale bei Patient*innen mit bimodaler Versorgung (CI und Hörgerät) während der zweijährigen CI-Rehabilitation. Material und Methoden An[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Phoniatrisch-pädaudiologische Aspekte 2020