cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
MPEC 2024-R248 : 2024 RM11
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 RM11

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Additional file 1 of Modelling and predicting the spatio-temporal spread of COVID-19 in Italy
Creators: name: Giuliani, Diego
name: Dickson, Maria Michela
name: Espa, Giuseppe
name: Santi, Flavio
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1 Supplemental information 1 Methodological details, and further results.
(501232) Elizabeth [Hunt]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(501234) Mary Brereton
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Influence of cosmic-ray variability on the monsoon rainfall and temperature
Creators: name: Badruddin
name: Aslam, O. P. M
Publisher: name: arXiv
Year: 2014
Subjects: subject: Space Physics (physics.space-ph)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Atmospheric and Oceanic Physics (physics.ao-ph)
subject: FOS: Physical sciences

description: We study the role of galactic cosmic ray (GCR) variability in influencing the rainfall variability in Indian Summer Monsoon Rainfall (ISMR) season. We find that on an average during 'drought' (low ISMR) periods in India, GCR flux is decreasing, and during 'flood' (high ISMR) periods, GCR flux is increasing. The results of our analysis suggest for a possibility that the decreasing GCR flux during the summer monsoon season in India may suppress the rainfall. On the other hand, increasing GCR flux may enhance the rainfall. We suspect that in addition to real environmental conditions, significant levitation/dispersion of low clouds and hence reduced possibility of collision/coalescence to form raindrops suppresses the rainfall during decreasing GCR flux in monsoon season. On the other hand, enhanced collision/coalescence efficiency during increasing GCR flux due to electrical effects may contribute to enhancing the rainfall. Based on the observations, we put forward the idea that, under suitable environmental conditions, changing GCR flux may influence precipitation by suppressing/enhancing it, depending upon the decreasing/increasing nature of GCR flux variability during monsoon season in India, at least. We further note that the rainfall variability is inversely related to the temperature variation during ISMR season. We suggest an explanation, although speculative, how a decreasing/increasing GCR flux can influence the rainfall and the temperature. We speculate that the proposed hypothesis, based on the Indian climate data can be extended to whole tropical and sub-tropical belt, and that it may contribute to global temperature in a significant way. If correct, our hypothesis has important implication for the sun - climate link.
description: 13 pages, 5 figures and 6 tables. Accepted to J. Atmos. Solar-Terr. Phys., 2014(http://dx.doi.org/10.1016/j.jastp.2014.11.005)
(501229) Helen Davenport
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Thiol-based chemical probes exhibit antiviral activity against SARS-CoV-2 via allosteric disulfide disruption in the spike glycoprotein
Creators: name: Yang, Jing
name: Radi, Rafael
name: Boucher, Richard C.
name: Carroll, Kate S.
name: Fu, Ling
name: Zeida, Ari
name: Shi, Yunlong
name: Mallory, Michael L.
name: Pickles, Raymond J.
name: Edwards, Caitlin E.
name: Machado, Matías R.
name: Liu, Keke
name: Baric, Ralph S.
name: Sastre, Santiago
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: The development of small-molecules targeting different components of SARS-CoV-2 is a key strategy to complement antibody-based treatments and vaccination campaigns in managing the COVID-19 pandemic. Here, we show that two thiol-based chemical probes that act as reducing agents, P2119 and P2165, inhibit infection by human coronaviruses, including SARS-CoV-2, and decrease the binding of spike glycoprotein to its receptor, the angiotensin-converting enzyme 2 (ACE2). Proteomics and reactive cysteine profiling link the antiviral activity to the reduction of key disulfides, specifically by disruption of the Cys379–Cys432 and Cys391–Cys525 pairs distal to the receptor binding motif in the receptor binding domain (RBD) of the spike glycoprotein. Computational analyses provide insight into conformation changes that occur when these disulfides break or form, consistent with an allosteric role, and indicate that P2119/P2165 target a conserved hydrophobic binding pocket in the RBD with the benzyl thiol-reducing moiety pointed directly toward Cys432. These collective findings establish the vulnerability of human coronaviruses to thiol-based chemical probes and lay the groundwork for developing compounds of this class, as a strategy to inhibit the SARS-CoV-2 infection by shifting the spike glycoprotein redox scaffold.
Rotation group bias and the persistence of misclassification errors in the Current Population Surveys
Creators: name: Feng, Shuaizhang
name: Hu, Yingyao
name: Sun, Jiandong
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: We develop a general misclassification model to explain the so-called “Rotation Group Bias (RGB)” problem in the Current Population Surveys, where different rotation groups report different labor force statistics. The key insight is that responses to repeated questions in surveys can depend not only on unobserved true values, but also on previous responses to the same questions. Our method provides a framework to understand why unemployment rates in rotation group one are higher than those in other rotation groups in the CPS, without imposing any a priori assumptions on the existence and direction of RGB. Using our method, we provide new estimates of the U.S. unemployment rates, which are much higher than the official series, but lower than previous estimates that ignored persistence in misclassification.
Entanglement Verification with Deep Semi-supervised Machine Learning
Creators: name: Zhang, Lifeng
name: Chen, Zhihua
name: Fei, Shao-Ming
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum entanglement lies at the heart in quantum information processing tasks. Although many criteria have been proposed, efficient and scalable methods to detect the entanglement of generally given quantum states are still not available yet, particularly for high-dimensional and multipartite quantum systems. Based on FixMatch and Pseudo-Label method, we propose a deep semi-supervised learning model with a small portion of labeled data and a large portion of unlabeled data. The data augmentation strategies are applied in this model by using the convexity of separable states and performing local unitary operations on the training data. We verify that our model has good generalization ability and gives rise to better accuracies compared to traditional supervised learning models by detailed examples.
Non-linear hydrodynamics of axion dark matter: relative velocity effects and "quantum forces"
Creators: name: Marsh, David J. E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The non-linear hydrodynamic equations for axion/scalar field dark matter (DM) in the non-relativistic Madelung-Shcrödinger form are derived in a simple manner, including the effects of universal expansion and Hubble drag. The hydrodynamic equations are used to investigate the relative velocity between axion DM and baryons, and the moving-background perturbation theory (MBPT) derived. Axions massive enough to be all of the DM do not affect the coherence length of the relative velocity, but the MBPT equations are modified by the inclusion of the axion effective sound speed. These MBPT equations are necessary for accurately modelling the effects of axion DM on the formation of the first cosmic structures, and suggest that the 21cm power spectrum could improve constraints on axion mass by up to four orders of magnitude with respect to the current best constraints. A further application of these results uses the "quantum force" analogy to model scalar field gradient energy in a smoothed-particle hydrodynamics model of axion DM. Such a model can treat axion DM in the non-linear regime and could be incorporated into existing N-body codes.
description: 8 pages, 3 figures. v2: longer discussion of SPH smoothing. v3: some discussion added, published in PRD
Collaboration between clinical and academic laboratories for sequencing SARS-CoV-2 genomes
Creators: name: Rodino, Kyle G.
name: Hagan, Robert S.
name: Jones, Corbin D.
name: Everett, John
name: Wang, Jeremy
name: Hawken, Shawn
name: Bushman, Frederic
name: Miller, Melissa B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Genomic sequencing of SARS-CoV-2 continues to provide valuable insight into the ever-changing variant makeup of the COVID-19 pandemic. More than three million SARS-COV-2 genomes have been deposited in GISAID, but contributions from the United States, particularly through 2020, lagged behind the global effort. The primary goal of clinical microbiology laboratories is seldom rooted in epidemiologic or public health testing and many labs do not contain in-house sequencing technology. However, we recognized the need for clinical microbiologists to lend expertise, share specimen resources, and partner with academic laboratories and sequencing cores to assist in SARS-COV-2 epidemiologic sequencing efforts. Here we describe two clinical and academic laboratory collaborations for SARS-COV-2 genomic sequencing. We highlight roles of the clinical microbiologists and the academic labs, outline best practices, describe two divergent strategies in accomplishing a similar goal, and discuss the challenges with implementing and maintaining such programs.
Two-step series estimation and specification testing of (partially) linear models with generated regressors
Creators: name: Hsu, Yu-Chin
name: Liao, Jen-Che
name: Lin, Eric S.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: Evolutionary Biology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: This paper studies three semiparametric models that are useful and frequently encountered in applied econometric work—a linear and two partially linear specifications with generated regressors, i.e., the regressors that are unobserved, but can be nonparametrically estimated from the data. Our framework allows for generated regressors to appear in linear or nonlinear components of partially linear models. We propose two-step series estimators for the finite-dimensional parameters, establish their n-consistency (with sample size n) and asymptotic normality, and provide the asymptotic variance formulae that take into account the estimation error of generated regressors. Moreover, we develop a nonparametric specification test for the models considered. Numerical performances of the proposed estimators and test via simulation experiments and an empirical application illustrate the utility of our approach.
On the Capacity of the Wiener Phase-Noise Channel: Bounds and Capacity Achieving Distributions
Creators: name: Khanzadi, M. Reza
name: Krishnan, Rajet
name: Söder, Johan
name: Eriksson, Thomas
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: In this paper, the capacity of the additive white Gaussian noise (AWGN) channel, affected by time-varying Wiener phase noise is investigated. Tight upper and lower bounds on the capacity of this channel are developed. The upper bound is obtained by using the duality approach, and considering a specific distribution over the output of the channel. In order to lower-bound the capacity, first a family of capacity-achieving input distributions is found by solving a functional optimization of the channel mutual information. Then, lower bounds on the capacity are obtained by drawing samples from the proposed distributions through Monte-Carlo simulations. The proposed capacity-achieving input distributions are circularly symmetric, non-Gaussian, and the input amplitudes are correlated over time. The evaluated capacity bounds are tight for a wide range of signal-to-noise-ratio (SNR) values, and thus they can be used to quantify the capacity. Specifically, the bounds follow the well-known AWGN capacity curve at low SNR, while at high SNR, they coincide with the high-SNR capacity result available in the literature for the phase-noise channel.
description: IEEE Transactions on Communications, 2015
MPEC 2024-R249 : 2024 RN11
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 RN11

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
title: Annie M.A.H. Rogers and the admission of women to the University of Oxford : a study of family, society and reform in the late nineteenth and early twentieth centuries
Creators: name: Gilbert, Rosemary
Publisher: name: University of Kent
Year: 2023

description: This thesis examines the career of Annie Rogers in relation to the movement for the admission of women to the University of Oxford. It shows that a family had an influence on the reform of a university and on the development of the professional class. It consists of two sections. The first part examines the intellectual and social formation of Annie Rogers' family in the Oxford context and its influence on her in the type of role she played. An account and analysis of her role in the admission of women to Oxford University, with an examination and comparison of the parts some other people played in it, forms the second, and larger part of the thesis. Extensive research has been undertaken into a large quantity of unpublished papers of the Rogers family housed at the Bodleian Library, the British Library and elsewhere, in addition to sources at Oxford relating to Annie Rogers, and the movement for the admission of women to the University. The history of this professional, middle-class, political, academic family runs parallel with the development of the professional middle-class, from the end of the eighteenth century to the beginning of the twentieth. It influenced Annie Rogers in the kind of person she became and the type of role she adopted in the campaign for the admission of women to the University of Oxford. Her particular strategies played a significant part in obtaining membership of the University for women, thereby contributing to their admittance to the professions and to senior posts within them.
(501227) Hilda Margaret Weaver
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(501228) George Charles Maslen
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
FORMATION OF MODERN APPROACHES TO THE DEVELOPMENT OF MANAGERIAL SKILLS AND LEADERSHIP SKILLS OF STUDENTS OF HIGHER EDUCATION ORGANIZATIONS
Creators: name: Tashlanova, Nigora
name: Xabibullayev, Muxammaddiyor
Publisher: name: Zenodo
Year: 2023

description: The science of modern pedagogy develops guidelines for the comprehensive, diverse perspective of management ideas and their application in educational practice. It is impossible to imagine the solution of management problems in the process of higher education without the development of managerial skills, professional skills and leadership skills in students. The introduction of such an approach serves to prevent accidents and contingencies in management.
Additional file 1 of Tickborne disease awareness and protective practices among U.S. Forest Service employees from the upper Midwest, USA
Creators: name: Schotthoefer, Anna
name: Stinebaugh, Kathryn
name: Martin, Michael
name: Munoz-Zanzi, Claudia
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Additional file 1. The survey instrument used in the study to assess tick-borne disease Knowledge, Attitudes, and Practices (KAP) in U. S. Forest Service employees, and summaries of reported outdoor activities and tick exposures while doing outdoor activities. Table S1. Knowledge survey. The questions and correct responses used to assess employee tick-borne disease Knowledge in the survey. Table S2. Attitudes survey. The questions and possible responses used in the Attitudes section of the survey. Table S3. Practices survey. The questions and possible responses used to assess employee use of protective practices in the Practices section of the survey. Table S4. Summary of outdoor activities. Frequencies (%) of respondents that indicated that they had done the outdoor activities listed at least 3 times per year while in Wisconsin/Minnesota. Table S5. Summary of tick exposure. Frequencies (%) of respondents that indicated that they had high or low tick exposure or that they never encountered ticks while doing the listed outdoor activities.
Numerical and Experimental Investigation of a Lab-Scale Paraffin Motor with Swirl Injection of Gaseous Oxygen
Creators: name:  M.T. MIGLIORINO
name:   M. FABIANI
name:   C. PARAVAN
name:   D. BIANCHI
name:   F. NASUTI
name:   L. GALFETTI
name:   R.C. PELLEGRINI
Publisher: name: Proceedings of  the 9th European Conference for Aerospace Sciences. Lille, France, 27 June - 1 July, 2022
Year: 2022
Subjects: PROPULSION PHYSICS
HYBRID PROPULSION

description: The regression rate performance and flow physics of a lab-scale hybrid rocket motor are numerically and experimentally investigated in this paper. The motor burns gaseous oxygen and a paraffin fuel based on a commercial microcrystalline wax. The oxygen is fed to the combustion chamber through a swirl injector allowing optical access to the burning grain. A long prechamber and postchamber allow, respectively, to limit injection swirl effects and to favor propellants mixing. Tested specimens feature grain length of 50 mm, with external diameter of 30 mm and initial port diameter in the range 5 to 20 mm. Firing tests were conducted varying oxygen mass flow rate from 5 to 10 g/s, obtaining average oxidizer mass fluxes in the range 20-60 kg/(m2 s) and regression rates in the range 0.5 to 2.5 mm/s. Regression rates obtained by classical thickness-over-time (TOT) averaging procedure are compared to fuel time-resolved ballistics. Time-resolved data are obtained by an optical method enabling port diameter tracking. A numerical rebuilding of the experimental data is performed with Reynolds-averaged NavierStokes simulations. Sub-models accounting for the effects of turbulence, chemistry, radiation, fluid/surface interaction and entrainment, which were previously validated through rebuilding of other higher scale firing tests with axial injection, are not sufficient to satisfactorily rebuild the current data based on swirl injection. The model, in fact, yields regression rates which severely underpredict the experimental ones. Since the radiation contribution is modest for the small diameters and low pressures investigated, and uncertainties on thermophysical properties of paraffin do not strongly affect regression rate values, the reason for the underestimation has been identified in factors affecting convective heat transfer modelling. Indeed, it has been found that introducing an axisymmetric swirling flow strongly increases the numerically obtained regression rate, yielding a more favorable comparison with experimental data. In the final manuscript, experimental results and numerical predictions will be presented and thoroughly discussed to highlight the benefits, limitations, and future evolution of this approach as well as the gained insight into the various driving mechanisms. Acknowledgements This work is funded by the Italian Space Agency in the framework of the Hybrid Paraffin Propulsion RD Activities Programme.
Additional file 1 of The intestinal microbiome, weight, and metabolic changes in women treated by adjuvant chemotherapy for breast and gynecological malignancies
Creators: name: Atara Uzan-Yulzari
name: Morr, Maya
name: Tareef-Nabwani, Hala
name: Ziv, Oren
name: Magid-Neriya, Dafna
name: Armoni, Ran
name: Muller, Efrat
name: Leibovici, Anca
name: Borenstein, Elhanan
name: Louzoun, Yoram
name: Shai, Ayelet
name: Koren, Omry
Publisher: name: figshare
Year: 2020
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Physiology
subject: Pharmacology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Computational Biology

description: Additional file 1: Figure S1. Dietary intake from patient that gained and those that did not gain weight after chemotherapy, based on food diaries. Figure S2. Bar graph presenting the association between weight gain and different clinical factors (LIST).
(501223) Esther Jane Weaver
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
การศึกษาวิธีการเรียนรู้เชิงรุกโดยผู้เรียนสร้างความรู้ด้วยตนเองเพื่อพัฒนาทักษะการคิดวิเคราะห์ นักเรียนชั้นประถมศึกษาปีที่ 6 โรงเรียนบ้านวังท่าดี สำนักงานเขตพื้นที่การศึกษาประถมศึกษาเพชรบูรณ์ เขต 3
Creators: name: ปฏิวัติ พุทธะศักดิ์เมธี
Publisher: name: ศูนย์สนับสนุนและพัฒนาการเรียนการสอน มหาวิทยาลัยรังสิต
Year: 2015
Subjects: Active Learning through Constructivism Activities
Analytical Thinking Skills
Prathom Suksa
การเรียนรู้แบบเชิงรุกโดยผู้เรียนสร้างความรู้ด้วยตนเอง
ทักษะการคิดวิเคราะห์
ประถมศึกษา

description: วารสารพัฒนาการเรียนการสอน, 9, 1, 68-79
Radiolabelling and preclinical characterisation of [89Zr]Zr-Df-ATG-101 bispecific to PD-L1/4-1BB
Creators: name: Cao, Zhipeng
name: Wichmann, Christian
name: Burvenich, Ingrid
name: Murray-Rust, Laura
name: Guo, Nancy
name: Rigopoulos, Angela
name: O'Keefe, Graeme Joseph
name: Scott, Fiona
name: Lorensuhewa, Nirmal
name: Lynch, Kevin Patrick
name: Scott, Andrew
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 3211
subject: Oncology and carcinogenesis
classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 320407
subject: Innate immunity
classificationCode: 3202
subject: Clinical sciences
classificationCode: 3204
subject: Immunology
subject: FOS: Clinical medicine

description: Purpose: ATG-101, a bispecific antibody that simultaneously targets the immune checkpoint PD-L1 and the costimulatory receptor 4-1BB, activates exhausted T cells upon PD-L1 crosslinking. Previous studies demonstrated promising anti-tumour efficacy of ATG-101 in preclinical models. Here, we labelled ATG-101 with 89Zr to confirm its tumour targeting effect and tissue biodistribution in a preclinical model. We also evaluated the use of immuno-PET to study tumour uptake of ATG-101 in vivo. Methods: ATG-101, anti-PD-L1, and an isotype control were conjugated with p-SCN-Deferoxamine (Df). The Df-conjugated antibodies were radiolabelled with 89Zr, and their radiochemical purity, immunoreactivity, and serum stability were assessed. We conducted PET/MRI and biodistribution studies on [89Zr]Zr-Df-ATG-101 in BALB/c nude mice bearing PD-L1-expressing MDA-MB-231 breast cancer xenografts for up to 10 days after intravenous administration of [89Zr]Zr-labelled antibodies. The specificity of [89Zr]Zr-Df-ATG-101 was evaluated through a competition study with unlabelled ATG-101 and anti-PD-L1 antibodies. Results: The Df-conjugation and [89Zr]Zr -radiolabelling did not affect the target binding of ATG-101. Biodistribution and imaging studies demonstrated biological similarity of [89Zr]Zr-Df-ATG-101 and [89Zr]Zr-Df-anti-PD-L1. Tumour uptake of [89Zr]Zr-Df-ATG-101 was clearly visualised using small-animal PET imaging up to 7 days post-injection. Competition studies confirmed the specificity of PD-L1 targeting in vivo. Conclusion: [89Zr]Zr-Df-ATG-101 in vivo distribution is dependent on PD-L1 expression in the MDA-MB-231 xenograft model. Immuno-PET with [89Zr]Zr-Df-ATG-101 provides real-time information about ATG-101 distribution and tumour uptake in vivo. Our data support the use of [89Zr]Zr-Df-ATG-101 to assess tumour and tissue uptake of ATG-101.
Additional file 1 of Modelling and predicting the spatio-temporal spread of cOVID-19 in Italy
Creators: name: Giuliani, Diego
name: Dickson, Maria Michela
name: Espa, Giuseppe
name: Santi, Flavio
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1 Supplemental information 1 Methodological details, and further results.
(501224) William Thomas Weaver
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Black American Maternal Prenatal Choline, Offspring Gestational Age at Birth, and Developmental Predisposition to Mental Illness
Creators: name: Hoffman, M.C.
name: Wyrwa, A.
name: Zeisel, S.H.
name: Noonan, K.
name: Law, A.J.
name: Nakimuli-Mpungu, E.
name: McCarthy, L.
name: Hunter, S.K.
name: Freedman, R.
name: D'Alessandro, A.
name: Christians, U.
Publisher: name: Oxford University Press
Year: 2021

description: Black Americans have increased risk for schizophrenia and other mental illnesses with prenatal origins. Prenatal choline promotes infant brain development and behavioral outcomes, but choline has not been specifically assessed in Black Americans. Pregnant women (N = 183, N = 25 Black Americans) enrolled in a study of prenatal stressors and interactions with prenatal choline. Black American women had lower 16-week gestation plasma choline than Whites. Lower choline was not related to obesity, income, or metabolic genotypes. Pregnant women in rural Uganda have higher choline levels than Black American women. Black Americans' lower choline was associated with higher hair cortisol, indicative of higher stress. Lower maternal choline was associated with offsprings' lower gestational age at birth and with decreased auditory P50 inhibition, a marker of inhibitory neuron development. Behavioral development was assessed on the Infant Behavior Questionnaire-R-SF (IBQ-R) at 3 months. Lower Black American maternal gestational choline was associated with lower infant IBQ-R Orienting/Regulation, indicating decreased attention and relation to caregivers. Additional evidence for developmental effects of choline in Black Americans comes from a randomized clinical trial of gestational phosphatidylcholine supplementation versus placebo that included 15 Black Americans. Phosphatidylcholine increased gestational age at birth and newborn P50 inhibition and decreased Social Withdrawn and Attention problems at 40 months of age in Black Americans' offspring compared to placebo. Inhibitory and behavioral deficits associated with lower prenatal choline in offspring of Black American women indicate potential developmental predispositions to later mental illnesses that might be ameliorated by prenatal choline or phosphatidylcholine supplementation.
Transitions to valence-bond solid order in a honeycomb lattice antiferromagnet
Creators: name: Pujari, Sumiran
name: Alet, Fabien
name: Damle, Kedar
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We use Quantum Monte-Carlo methods to study the ground state phase diagram of a S=1/2 honeycomb lattice magnet in which a nearest-neighbor antiferromagnetic exchange J (favoring Néel order) competes with two different multi-spin interaction terms: a six-spin interaction Q_3 that favors columnar valence-bond solid (VBS) order, and a four-spin interaction Q_2 that favors staggered VBS order. For Q_3 ~ Q_2 >> J, we establish that the competition between the two different VBS orders stabilizes Néel order in a large swathe of the phase diagram even when J is the smallest energy-scale in the Hamiltonian. When Q_3 >> (Q_2,J) (Q_2 >> (Q_3,J)), this model exhibits at zero temperature phase transition from the Néel state to a columnar (staggered) VBS state. We establish that the Néel-columnar VBS transition is continuous for all values of Q_2, and that critical properties along the entire phase boundary are well-characterized by critical exponents and amplitudes of the non-compact CP^1 (NCCP^1) theory of deconfined criticality, similar to what is observed on a square lattice. However, a surprising three-fold anisotropy of the phase of the VBS order parameter at criticality, whose presence was recently noted at the Q_2=0 deconfined critical point, is seen to persist all along this phase boundary. We use a classical analogy to explore this by studying the critical point of a three-dimensional XY model with a four-fold anisotropy field which is known to be weakly irrelevant at the three-dimensional XY critical point. In this case, we again find that the critical anisotropy appears to saturate to a nonzero value over the range of sizes accessible to our simulations.
description: 14 pages
Additional file 1 of English version of the self-administered Fabry Pain Questionnaire for adult patients
Creators: name: Jovanovic, Ana
name: Klassen, Philipp
name: Heuschmann, Peter
name: Sommer, Claudia
name: Roberts, Mark
name: Üçeyler, Nurcan
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Computational Biology

description: Additional file 1: English version of the Würzburg Fabry Pain Questionnaire (enFPQ).
title: "I Need to Teach My Own Children"
title: A Constructivist Grounded Theory Study of Home-schooling in Trinidad and Tobago
titleType: Subtitle
Creators: name: St Rose, Nneka
Publisher: name: Lancaster University
Year: 2022

description: Home-schooling as an alternative form of education has grown exponentially globally. Its growth in developed countries has seen the educational practice carve out a distinct space in political, educational, and academic discourse. In Trinidad and Tobago (T&T), educational discourse does not integrate the home-school rhetoric despite the noted growth and its increasing popularity in the educational landscape. Families are home-schooling with limited interference within a relatively untainted framework. This study utilized a Constructivist Grounded Theory (CGT) method to better understand this practice in such a small society. It recognized the growth of home-schooling in T&T as an educational experiment, with possibilities to explore education done differently in its current incubator status. The 11 home-schooling parents of this study who were interviewed unveiled a manner of conceptualizing and enacting education that aligned closely with the writings of critical pedagogy: revealing a liberating, transformative education. Their home-school journey demonstrated a cognitive shift from many of the elements of the formal system that critical pedagogical theorists have heavily analyzed, capturing four emergent questions from the data: (a) who is my child? (b) what does he/she need? (c) how can I fulfil that need? (d) what kind of person am I educating? Keywords: Home-school, pedagogy, education, Constructivist Grounded Theory.
(501226) Alice [Dorothy] Weaver
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Who Likes Library Lingo? Evaluating Library-Specific Terminology Through First-Click Testing
Creators: name: Walston, Felicity
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022
Subjects: Libraries -- Evaluation
User experience testing
Information seeking behaviors
Library websites

description: Users of an academic library can vary widely, and it is the library’s duty to make their website accessible to everyone along that spectrum. This project aims to improve readability of three of the most accessed research tools on the website of The University of North Carolina at Chapel Hill’s University Libraries. We utilized first-click tests to compare the clarity of alternative names for these research tools using common English words. This study also collected information about participants’ English proficiency level to examine how it affects the understanding of these terms. There were not enough non-native English speakers who participated in the study to make specific conclusions based on native language. General conclusions across all participants included recommendations to keep one research term, to replace the second with the variable term we tested, and to retest the third.
Information Seeking and Behavior Among Collectors of Vinyl Records
Creators: name: Newgard, Benjamin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022
Subjects: Information-seeking behavior
Searching behavior
Phonograph records
Information literacy
Information skills
Media literacy

description: The study presented in this paper explores the information seeking and behavior of committed collectors of vinyl records. Through a series of thorough, semi-structured interviews with hobbyist collectors, this study provides a deeper understanding of how they search for, assess, share, and utilize different types of information to support their collecting activities. Patterns and themes in the interview data are evinced through qualitative coding and analysis. In doing so, this study introduces new contexts and perspectives to the field of leisure and information studies, and contributes additional insight into how non-professional collectors and other serious hobbyists address their information needs without the support of a formal institution or organization.
Vulgar Remarks Detection in Chittagonian Dialect of Bangla
Creators: name: Mahmud, Tanjim
name: Ptaszynski, Michal
name: Masui, Fumito
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences

description: The negative effects of online bullying and harassment are increasing with Internet popularity, especially in social media. One solution is using natural language processing (NLP) and machine learning (ML) methods for the automatic detection of harmful remarks, but these methods are limited in low-resource languages like the Chittagonian dialect of Bangla.This study focuses on detecting vulgar remarks in social media using supervised ML and deep learning algorithms.Logistic Regression achieved promising accuracy (0.91) while simple RNN with Word2vec and fastTex had lower accuracy (0.84-0.90), highlighting the issue that NN algorithms require more data.
description: 5 pages
Educating About/for Food Security Through Environmental Education: A Qualitative Study of Teacher Education Programs in Ontario
Creators: name: Valeri, Alishia Adele
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2020
Subjects: Food security
Integration strategies
Ways of thinking
Teacher Education
Environmental Education
Ontario
Curriculum Documents

description: Food insecurity is on the rise worldwide and within Canada due to a myriad of factors such as climatic instability, rising food prices and unsustainable food production practices. In this context, educational systems (e.g. schools and universities) can contribute to developing knowledge and awareness of food insecurity as well as fostering new ways of thinking and engaging with food premised on just and sustainable food systems. This study is situated within the field of environmental education where there is a growing body of research at the intersections of food and the environment. Likewise, it was guided by the theoretical framing of EcoJustice Education, which offers a way of teaching and learning premised on the belief that our thoughts and actions can foster and enhance more social and ecologically equitable connections between food and the environment. By engaging in semi-structured interviews with teacher educators in select teacher education programs in Ontario and conducting document reviews, I investigated how the integration of the topic of food security is taking place—or not—in the initial training of future teachers in the province. The results showed that integration is not consistent across the different organizational levels of the programs investigated (i.e. whole-program level and classroom level). Moreover, the interviews with teacher educators revealed that any practices aiming at the integration of food security topics in BEd programs were primarily guided by a sustainable cultures perspective, which sees the world as having interconnected relationships amongst all living things. This view is supported by the data analysis of interviews with teacher educators, the Ontario Ministry of Education curriculum documents, and select course syllabi. On the other hand, the school curriculum documents contained conflicting views on the topic, including an understanding of the world as being based on hierarchized relationships. This research advances the field of environmental education by further adding to the limited scholarship on the topic of food security in the context of EE, as well as contributing to an account of food security education and EE with a focus on teacher education in Ontario.
(501225) Ellen Mary Weaver
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The Picts in Perspective: How Museum Educators Can Revitalize Modern Connections with this Early Medieval Civilization
Creators: name: Reinert, Claire
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: The Picts, an early medieval Scottish civilization, are one of Britain’s most mysterious historical populations.  The mystery primarily arises from the lack of documentary evidence that can be confidently attributed to the Picts, leaving scholars with a host of questions: what was the Picts’ social identity?  What language did they speak?  Pictish scholarship offers many possible answers, but museum educators are left with the question of how to create programs about this mysterious population with little concrete evidence.  The purpose of this study is to provide museum educators with a review of ten initiatives that have been undertaken by British organizations and individuals focusing on populations similar to the Picts.  I offer a summary of each initiative with an analysis of how they could be adapted for programs about the Picts.  An important consequence of revitalizing Pictish educational programs will be a more concrete connection between modern Scottish people and their cultural heritage.
Additional file 3 of English version of the self-administered Fabry Pain Questionnaire for adult patients
Creators: name: Jovanovic, Ana
name: Klassen, Philipp
name: Heuschmann, Peter
name: Sommer, Claudia
name: Roberts, Mark
name: Üçeyler, Nurcan
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Computational Biology

description: Additional file 3: Supplementary methods.
MPEC 2024-R250 : 2024 QV5
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 QV5

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.