cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Ras transformation results in cleavage of reticulon protein Nogo-B that is associated with impairment of IFN response
Creators: name: Dae-Gyun Ahn
name: Sharif, Tanveer
name: Chisholm, Kenneth
name: Devanand M Pinto
name: Gujar, Shashi A
name: Lee, Patrick WK
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cell Biology
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Dysregulation of Ras signaling is the major cause of various cancers. Aberrant Ras signaling, however, provides a favorable environment for many viruses, making them suitable candidates as cancer-killing therapeutic agents. Susceptibility of cancer cells to such viruses is mainly due to impaired type I interferon (IFN) response, often as a result of activated Ras/ERK signaling in these cells. In this study, we searched for cellular factors modulated by Ras signaling and their potential involvement in promoting viral oncolysis. We found that upon Ras transformation of NIH-3T3 cells, the N-terminus of Nogo-B (reticulon 4) was proteolytically cleaved. Interestingly, Nogo knockdown (KD) in non-transformed and Ras-transformed cells both enhanced virus-induced IFN response, suggesting that both cleaved and uncleaved Nogo can suppress IFN response. However, pharmacological blockade of Nogo cleavage in Ras-transformed cells significantly enhanced virus-induced IFN response, suggesting that cleaved Nogo contributes to enhanced IFN suppression in these cells. We further showed that IFN suppression associated with Ras-induced Nogo-B cleavage was distinct from but synergistic with that associated with an activated Ras/ERK pathway. Our study therefore reveals an important and novel role of Nogo-B and its cleavage in the suppression of anti-viral immune responses by oncogenic Ras transformation.
Akt suppresses DLK for maintaining self-renewal of mouse embryonic stem cells
Creators: name: Cheng-Chung Wu
name: Wu, Hong-Jin
name: Chia-Hui Wang
name: Chia-Hua Lin
name: Shu-Ching Hsu
name: Chen, Yi-Rong
name: Hsiao, Michael
name: Schuyler, Scott C
name: Lu, Frank Leigh
name: Nianhan Ma
name: Lu, Jean
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Developmental Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Biochemistry

description: Mouse embryonic stem cells (ES cells) can proliferate indefinitely. To identify potential signals involved in suppression of self-renewal, we previously screened a kinase/phosphatase expression library in ES cells, and observed that inhibition of Dual Leucine zipper-bearing Kinase (DLK) increased relative cell numbers. DLK protein was detected in both the pluripotent and differentiated states of mouse ES cells while DLK kinase activity increased upon differentiation. Overexpression of DLK in mouse ES cells displayed reductions in relative cell/colony numbers and Nanog expression, suggesting a suppressive role of DLK in self-renewal. By examining protein sequences of DLK, we identified 2 putative Akt phosphorylation sites at S584 and T659. Blocking PI3K/Akt signaling with LY-294002 enhanced DLK kinase activity dramatically. We found that Akt interacts with and phosphorylates DLK. Mutations of DLK amino acid residues at putative Akt phosphorylation sites (S584A, T659A, or S584A and T659A) diminished the level of DLK phosphorylation. While the mutated DLKs (S584A, T659A, or S584A and T659A) were expressed, a further reduction in cell/colony numbers and Nanog expression appeared in mouse ES cells. In addition, these mutant DLKs (S584A, T659A, or S584A and T659A) exhibited more robust kinase activity and cell death compared to wild type DLK or green fluorescence (GFP) controls. In summary, our results show that DLK functions to suppress self-renewal of mouse ES cells and is restrained by Akt phosphorylation.
Akt suppresses DLK for maintaining self-renewal of mouse embryonic stem cells
Creators: name: Cheng-Chung Wu
name: Wu, Hong-Jin
name: Chia-Hui Wang
name: Chia-Hua Lin
name: Shu-Ching Hsu
name: Chen, Yi-Rong
name: Hsiao, Michael
name: Schuyler, Scott C
name: Lu, Frank Leigh
name: Nianhan Ma
name: Lu, Jean
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Mouse embryonic stem cells (ES cells) can proliferate indefinitely. To identify potential signals involved in suppression of self-renewal, we previously screened a kinase/phosphatase expression library in ES cells, and observed that inhibition of Dual Leucine zipper-bearing Kinase (DLK) increased relative cell numbers. DLK protein was detected in both the pluripotent and differentiated states of mouse ES cells while DLK kinase activity increased upon differentiation. Overexpression of DLK in mouse ES cells displayed reductions in relative cell/colony numbers and Nanog expression, suggesting a suppressive role of DLK in self-renewal. By examining protein sequences of DLK, we identified 2 putative Akt phosphorylation sites at S584 and T659. Blocking PI3K/Akt signaling with LY-294002 enhanced DLK kinase activity dramatically. We found that Akt interacts with and phosphorylates DLK. Mutations of DLK amino acid residues at putative Akt phosphorylation sites (S584A, T659A, or S584A and T659A) diminished the level of DLK phosphorylation. While the mutated DLKs (S584A, T659A, or S584A and T659A) were expressed, a further reduction in cell/colony numbers and Nanog expression appeared in mouse ES cells. In addition, these mutant DLKs (S584A, T659A, or S584A and T659A) exhibited more robust kinase activity and cell death compared to wild type DLK or green fluorescence (GFP) controls. In summary, our results show that DLK functions to suppress self-renewal of mouse ES cells and is restrained by Akt phosphorylation.
title: Vid :
title: Directrices para la ejecución del examen de la distinción, la homogeneidad y la estabilidad.
titleType: Subtitle
Creators: name: (:Unas)
Publisher: name: Unknown
Year: 2008

description: La finalidad de estas directrices (“directrices de examen”) es elaborar los principios que figuran en la Introducción General (documento TG/1/3) y sus documentos TGP conexos, con objeto de que sirvan de orientación práctica y detallada para el examen armonizado de la distinción, homogeneidad y estabilidad (DHE) y en particular, para identificar los caracteres apropiados para el examen DHE y producir descripciones armonizadas de variedades.
The role of female cephalopod researchers: past and present
Creators: name: A. Louise Allcock
name: Boletzky, Sigurd Von
name: Bonnaud-Ponticelli, Laure
name: Brunetti, Norma E.
name: Néstor J. Cazzaniga
name: Hochberg, Eric
name: Ivanovic, Marcela
name: Lipinski, Marek
name: Marian, José E. A. R.
name: Chingis Nigmatullin
name: Nixon, Marion
name: Robin, Jean-Paul
name: Rodhouse, Paul G. K.
name: Vidal, Erica A. G.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Cancer
subject: Marine Biology
subject: Mathematics
subject: FOS: Mathematics
subject: Immunology
subject: FOS: Clinical medicine
subject: Evolutionary Biology
subject: FOS: Biological sciences

description: This paper explores the contribution that women past and present have made to cephalopod research. It includes short biographies of eight female cephalopod researchers who are now deceased: Jeanne Villepreux-Power, Anne Massy, Grace Watkinson, Grace Pickford, Anna Bidder, Zulma Castellanos, Katharina Mangold and Martina Roeleveld. In addition, biographies are provided for six female cephalopod researchers who are now retired but who have made an enormous contribution to cephalopod knowledge during their lifetimes: Nancy Voss, Marion Nixon, Joyce Wells, Julia Filippova, Eve Boucaud-Camou, and Renata Boucher-Rodoni. Online supplementary information provides a bibliography of the research outputs of these 14 researchers, who between them, since 1837 have published more than 800 scientific papers making an in-depth contribution to the field of cephalopod research.
Synthesis, characterization, and in vitro antioxidant and anticancer studies of ruthenium(III) complexes of symmetric and asymmetric tetradentate Schiff bases
Creators: name: Ikechukwu P. Ejidike
name: Ajibade, Peter A.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Cancer
Developmental Biology
Biological Sciences
Chemistry
Earth and Environmental Sciences
Biotechnology
Cell Biology
Biochemistry

description: Ruthenium(III) complexes of three tetradentate Schiff bases with N2O2 donors formulated as [RuCl(LL1)(H2O)], [RuCl(LL2)(H2O)] and [RuCl(LL3)(H2O)] were synthesized and characterized by elemental analyses, molar conductance, FTIR, and electronic spectral measurements. The FTIR data showed that the tetradentate Schiff base ligands coordinate to Ru ions through the azomethine nitrogen and enolic oxygen. The antioxidant activities of the complexes were investigated through scavenging activity on 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radicals. The DPPH activity for [RuCl(LL2)(H2O)] with IC50 = 0.031 mg mL−1 was higher than the values obtained for the other Ru(III) compounds. The study revealed that the synthesized Ru(III) complexes of the tetradentate Schiff base exhibited strong scavenging activities against DPPH and moderate against ABTS radicals. In addition, the antiproliferative studies of the complexes were also tested against human renal cancer cells (TK10), human melanoma cancer cells (UACC62), and human breast cancer cells (MCF7) using the SRB assay. The results indicated that the Ru(III) complexes showed low anticancer activities against the tested human cancer cell lines.
Zinc(II) complexes derived from imidazo[1,2-a]pyridin-2-ylacetic acid (HIP-2-ac): [Zn(IP-2-ac)2(H2O)] and unexpectedly, [Zn3(IP-2-ac)6(H2O)]·11H2O
Creators: name: Dylong, Agnieszka
name: Michał Sowa
name: Goldeman, Waldemar
name: Ślepokura, Katarzyna
name: Drożdżewski, Piotr
name: Bogumiła Szponar
name: Matczak-Jon, Ewa
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Chemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Medicine
subject: Biochemistry
subject: Biophysics

description: Two zinc(II) complexes based on imidazo[1,2-a]pyridin-2-ylacetate (IP-2-ac), [Zn(IP-2-ac)2(H2O)] (1) and [Zn3(IP-2-ac)6(H2O)]·11H2O (2), were synthesized and characterized by single-crystal X-ray diffraction. In both 1 and 2, zinc(II) ions are five-coordinate with N2O3 donor set, best described as a distorted trigonal-bipyramidal geometry. In 1, two IP-2-ac ligands chelate zinc(II) through a N,O donor set, whereas in 2, both bidentate and μ-bridging binding modes of IP-2-ac are observed. The crystal of 1 comprises discrete Zn(IP-2-ac)2(H2O) coordination entities combined into layers by hydrogen bonds. Inter-layer stabilization of the 3-D crystal lattice is provided by weak C–H⋯O contacts and π⋯π interactions. The structure of 2 consists of discrete trinuclear Zn3(IP-2-ac)6(H2O) coordination entities joined into crystal lattice by multiple water molecules.Compound 1 was characterized by FTIR and FT-Raman spectroscopy, and in terms of thermal stability. Furthermore, its antibacterial activity was tested against selected gram-positive, gram-negative bacteria, and Candida albicans yeast and compared with activity of previously reported [M(IP-2-ac)2(H2O)2]·2H2O (M = Co, Ni, Mn, Cd) complexes.
Synthesis, characterization, in vitro antioxidant and anticancer studies of ruthenium(III) complexes of symmetric and asymmetric tetradentate Schiff bases
Creators: name: Ikechukwu P. Ejidike
name: Ajibade, Peter A.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Cancer
Developmental Biology
Biological Sciences
Chemistry
Earth and Environmental Sciences
Biotechnology
Cell Biology
Biochemistry

description: Ruthenium(III) complexes of three tetradentate Schiff bases with N2O2 donors formulated as [RuCl(LL1)(H2O)], [RuCl(LL2)(H2O)] and [RuCl(LL3)(H2O)] were synthesized and characterized by elemental analyses, molar conductance, FTIR and electronic spectral measurements. The FTIR data showed that the tetradentate Schiff base ligands coordinate to Ru ions through the azomethine nitrogen and enolic oxygen. The antioxidant activities of the complexes were investigated through scavenging activity on DPPH and ABTS radicals. The DPPH activity for [RuCl(LL2)(H2O)] with IC50 = 0.031 mg/mL was higher than the values obtained for the other Ru(III) compounds. The study revealed that the synthesized Ru(III) complexes of the tetradentate Schiff base exhibited strong scavenging activities against DPPH and moderate against ABTS radicals. In addition, the antiproliferative studies of the complexes were also tested against human renal cancer cells (TK10), human melanoma cancer cells (UACC62) and human breast cancer cells (MCF7) using the SRB assay. The results indicated that the Ru(III) complexes showed low anticancer activities against the tested human cancer cell lines.
Zinc(II) complexes derived from imidazo[1,2-a]pyridin-2-ylacetic acid (HIP-2-ac): [Zn(IP-2-ac)2(H2O)] and unexpectedly, [Zn3(IP-2-ac)6(H2O)]·11H2O
Creators: name: Dylong, Agnieszka
name: Michał Sowa
name: Goldeman, Waldemar
name: Ślepokura, Katarzyna
name: Drożdżewski, Piotr
name: Bogumiła Szponar
name: Matczak-Jon, Ewa
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Chemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Medicine
subject: Biochemistry
subject: Biophysics

description: Two zinc(II) complexes based on imidazo[1,2-a]pyridin-2-ylacetate (IP-2-ac), [Zn(IP-2-ac)2(H2O)] (1) and [Zn3(IP-2-ac)6(H2O)]·11H2O (2), were synthesized and characterized by single-crystal X-ray diffraction. In both 1 and 2 zinc(II) ions are five-coordinate with N2O3 donor set, best described as a distorted trigonal-bipyramidal geometry. In 1, two IP-2-ac ligands chelate zinc(II) through a N,O donor set, whereas in 2 both bidentate and μ-bridging binding modes of IP-2-ac are observed. The crystal of 1 comprises discrete Zn(IP-2-ac)2(H2O) coordination entities combined into layers by hydrogen bonds. Inter-layer stabilization of the three-dimensional crystal lattice is provided by weak C—H···O contacts and π···π interactions. The structure of 2 consists of discrete trinuclear Zn3(IP-2-ac)6(H2O) coordination entities joined into crystal lattice by multiple water molecules.Compound 1 was characterized by FT-IR and FT-Raman spectroscopy, and in terms of thermal stability. Furthermore, its antibacterial activity was tested against selected Gram-positive, Gram-negative bacteria and C. albicans yeast and compared with activity of previously reported [M(IP-2-ac)2(H2O)2]·2H2O (M = Co, Ni, Mn, Cd) complexes.
Zinc(II) complexes derived from imidazo[1,2-a]pyridin-2-ylacetic acid (HIP-2-ac): [Zn(IP-2-ac)2(H2O)] and unexpectedly, [Zn3(IP-2-ac)6(H2
Creators: name: Dylong, Agnieszka
name: Michał Sowa
name: Goldeman, Waldemar
name: Ślepokura, Katarzyna
name: Drożdżewski, Piotr
name: Bogumiła Szponar
name: Matczak-Jon, Ewa
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Chemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Medicine
subject: Biochemistry
subject: Biophysics

description: Two zinc(II) complexes based on imidazo[1,2-a]pyridin-2-ylacetate (IP-2-ac), [Zn(IP-2-ac)2(H2O)] (1) and [Zn3(IP-2-ac)6(H2O)]·11H2O (2), were synthesized and characterized by single-crystal X-ray diffraction. In both 1 and 2, zinc(II) ions are five-coordinate with N2O3 donor set, best described as a distorted trigonal-bipyramidal geometry. In 1, two IP-2-ac ligands chelate zinc(II) through a N,O donor set, whereas in 2, both bidentate and μ-bridging binding modes of IP-2-ac are observed. The crystal of 1 comprises discrete Zn(IP-2-ac)2(H2O) coordination entities combined into layers by hydrogen bonds. Inter-layer stabilization of the 3-D crystal lattice is provided by weak C–H⋯O contacts and π⋯π interactions. The structure of 2 consists of discrete trinuclear Zn3(IP-2-ac)6(H2O) coordination entities joined into crystal lattice by multiple water molecules.Compound 1 was characterized by FTIR and FT-Raman spectroscopy, and in terms of thermal stability. Furthermore, its antibacterial activity was tested against selected gram-positive, gram-negative bacteria, and Candida albicans yeast and compared with activity of previously reported [M(IP-2-ac)2(H2O)2]·2H2O (M = Co, Ni, Mn, Cd) complexes.
The natural yeast extract isolated by ethanol precipitation inhibits melanin synthesis by modulating tyrosinase activity and downregulating melanosome transfer
Creators: name: Lee, Woo Jin
name: Rhee, Do Young
name: Bang, Seung Hyun
name: Kim, Su Yeon
name: Won, Chong Hyun
name: Lee, Mi Woo
name: Choi, Jee Ho
name: Chang, Sung Eun
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Cancer
Developmental Biology
Biological Sciences
Chemistry
Earth and Environmental Sciences
Biotechnology
Molecular Biology
Cell Biology
Biochemistry

description: This study was conducted to examine the effects of EP-2, a natural yeast extract isolated by ethanol precipitation from Saccharomyces cerevisiae, on melanogenesis and to determine its underlying mechanism of action. Our results show that although EP-2 is not a direct tyrosinase inhibitor, when EP-2 was added to the culture media of B16F10 melanoma cells, intracellular tyrosinase activity was decreased. However, EP-2 had no effect on the expression of microphthalmia-associated transcription factor or tyrosinase. EP-2 was found to inhibit melanogenesis and melanosome transfer when it was added to melanocytes and keratinocytes in coculture. In addition, protease-activated receptor 2, a key protein associated with melanosome transfer from melanocytes to keratinocytes, was downregulated in the presence of EP-2. In conclusion, EP-2 is a potent inhibitor of melanogenesis and its hypomelanogenic effect is related to the inhibition of tyrosinase activity and transfer of melanosomes.
Pressurised fluid extraction of polycyclic aromatic hydrocarbons and their polar oxidation products from atmospheric particles
Creators: name: Cochran, Richard E.
name: Kubátová, Alena
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Ecology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Molecular Biology
subject: Cell Biology
subject: Microbiology
subject: Medicine
subject: Engineering
subject: Biochemistry

description: An effective method utilising pressurised fluid extraction (PFE) to simultaneously extract polycyclic aromatic hydrocarbons (PAHs) and their polar oxidation products from atmospheric particulate matter (PM) is presented. The PFE method is advantageous over the traditional Soxhlet extraction due to its lower solvent consumption (9 mL compared to 90 mL) and shorter extraction time (15 min versus 18 h). Seventy compounds including PAHs and polar PAH oxidation products containing carbonyl (oxy-PAHs), hydroxyl (hydroxy-PAHs), and carboxylic acid (carboxy-PAHs) groups were targeted in the extraction of two different PM matrices: wood smoke (WS) and diesel exhaust (DE) PM. The PFE method was optimised and then compared to Soxhlet extraction for both PM matrices. The overall amounts of PAHs and their derivatives extracted from WS PM were slightly higher for the optimised PFE method (1849 ± 21 and 1863 ± 25 µg g−1 with dichloromethane (DCM) and methanol (MeOH), respectively) than those obtained with Soxhlet extraction (1726 ± 33 and 1769 ± 22 µg g−1 with DCM and MeOH, respectively). For DE PM (standard reference material (SRM) 2975) the overall amounts extracted by both methods were similar (average of 165 ± 6 µg g−1), agreeing with previously published values. The detailed evaluation of extraction efficiencies for WS PM showed similar amounts for unfunctionalised PAHs (1100 µg g−1) for both methods and solvents. For DE PM the mass yields for PAHs using PFE with DCM (62 ± 1 µg g−1) were the highest and nearly 20% higher than those obtained with MeOH (53 ± 2 µg g−1). The total mass yields of carboxy and hydroxy-PAHs from WS PM were also similar (412 ± 18 and 407 ± 11 µg g−1) for PFE and Soxhlet with MeOH, and higher than when DCM was used (371 ± 5 and 379 ± 12 µg g−1 for PFE and Soxhlet, respectively). For both matrices, the PFE yields for oxy-PAHs were higher than those obtained with Soxhlet.
Level of knowledge, attitude and practice of food outlet operators in Raub, Pahang morning market regarding the usage of repeatedly heated cooking oil- A cross sectional study
Creators: name: Iqbal, Zahid
name: Sivananthan1*, Manoharan
name: Elamaran2, Manoharan
name: Jasmin1, Kaur
name: Rajandran Kushha1
Publisher: name: figshare
Year: 2015
Subjects: subject: Education
subject: Microbiology
subject: FOS: Biological sciences
subject: Marine Biology
subject: Biophysics
subject: Biological Engineering
subject: Molecular Biology
subject: Genetics

description: From the literature survey, no published data was found regarding the topic of repeatedly heated cooking oil from Raub, Pahang. Thus this study was designed to evaluate the level of knowledge, attitude and practice of food outlet operators in Raub, Pahang morning market regarding the usage of repeatedly heated cooking oil. Food prepared from repeatedly heated cooking oil becoming a common issue in Malaysian setting. Few related articles to this topic (not focusing Raub) has been published previously also mentioning the seriousness of this practice to the health of human being. The main purpose of the food operators using repeatedly cooking oil because to saves cost. Level of knowledge, attitude and practice of food outlet operators in Raub, Pahang morning market regarding the usage of repeatedly heated cooking oil need to be improved. Many of the consumers not aware of the danger of using the repeatedly heated cooking oil. Only small portion of consumers aware of this situation. This small portion need to be changed to a bigger portion of consumers who well aware of this situation. This only can be achieved by doing campaign by health related agencies to create awareness that repeatedly heated cooking oil can cause harm to the health. Apart from these agencies, public must play a role in spreading the information to relatives, friends and family members. These spread of words can go viral if everyone aware the consequences of consuming repeatedly heated cooking oil. Prevention is better than cure.
Interaction of chenodeoxycholic acid with cholesterol in a model system studied by spin label probe method
Creators: name: Iqbal, Zahid
name: Sh. A. Kholova1
name: Kh. Sh. Dzhuraev1
name: I. Kh. Yusupov2
name: G. I. Likhtenshtein3*
Publisher: name: figshare
Year: 2015
Subjects: subject: Biotechnology
subject: Pathology
subject: Microbiology
subject: FOS: Biological sciences
subject: Education
subject: Botany
subject: Biological Techniques
subject: Molecular Biology
subject: Genetics

description: Interaction of cholesterol which is an essential structural component of animal cell membranes that is required to establish proper membrane permeability and fluidity and the bile chenodeoxycholic acid which significantly increased serum total cholesterol, and high-density-lipoprotein (HDL) cholesterol, and dissolves gallstones appears to be one of pivotal problem of biomedical gastroenterology. The methods of spin labels and spin probes have been proved to be power tools for solving structural and dynamical problems of chemistry and biology on molecular level. In present work the method of spin probes was used for investigation of quantitative interaction of cholesterol and chenodeoxycholic acid in ethanol possessing dielectric properties similar to ones of biological membranes. Using Electron Spin Resonance of nitroxide spin probe, it was shown that in the ethanol solution cholesterol molecules form aggregates, modeling a gallstone, which effectively bound chenodeoxycholic acid. The developed method can be used for study relationships between cholesterol and chenodeoxycholic acid in the in human blood, high-density-lipoproteins and gallstones.
DESCRIBE: An Instructional Approach to Support Students with Disabilities
Creators: name: Freville, Ben
name: Reardon, Colleen
Publisher: name: figshare
Year: 2022
Subjects: Education

description: This article discusses the DESCRIBE strategy that is designed to increase the accessibility of text-based primary sources for students with disabilities and other students who struggle with reading comprehension, making connections with background knowledge, and analyzing and synthesizing content information. DESCRIBE supports students in reading text-based primary sources in order to understand their unique features, contexts, main ideas, supporting details, and text-specific vocabulary in ways that are aligned with the Common Core State Standards (CCSS) and College, Career, and Civic Life Social Studies Standards (C3). The authors provide a description of the instructional steps of the strategy and a copy of the graphic organizer that is used when implementing the strategy. The article concludes with a description of a pilot study that supports the use of this strategy and points to the need for further research that includes a focus on student use of metacognitive skills.
Source Code for "Knowledge Grounded attention-based NMT model" . Inspired from DSTC-7 dialogue challenge code is customized for MT..
Creators: name: Israr, Huma
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 461104
subject: Neural networks
classificationCode: 470321
subject: Translation and interpretation studies
classificationCode: 460208
subject: Natural language processing
classificationCode: 470403
subject: Computational linguistics

description: The Source code of trained model for the Article " Knowledge-grounded Attention-based Neural machine translation Model " available in this folder.
Promoting Australian industry: CSIRO 1949-79
Creators: name: Upstill, Howard
Publisher: name: Swinburne
Year: 2024

description: This paper addresses the manner in which the Commonwealth Scientific and Industrial Research Organisation (CSIRO) transferred its technology to Australian industry during the period 1949 to 1979. The analysis is framed within the changing economic and political scene in Australia and the changing expectations for public research organisations such as CSIRO. During the 1950s and 1960s CSIRO gave little direct attention to the processes of technology transfer but instead, following the prevailing wisdom, focused on high quality science and relied on existing extension services and patenting to capture the benefits from its research. This 'science-push' approach proved successful for Australia's rural industries but, with a few exceptions, less so for the country's secondary industries. By the early 1970s CSIRO faced pressures for change, induced by a tougher economic climate and changing views on the role of public research institutions. A shift toward greater customer relevance in its research would also need to be matched by new thinking about technology transfer.
Tie heterogeneity in networks of interlocking directorates: a cost–benefit approach to firms’ tie choice
Creators: name: Brennecke, Julia
name: Rank, Olaf N.
Publisher: name: Swinburne
Year: 2024

description: This conceptual paper investigates the creation of interlocking directorate ties focusing on firms’ choice between sent, received, and undirected board interlocks. Drawing on a framework on the benefits of board interlocks stemming from resource dependence theory, we synthesize prior research on the consequences of interlocks and demonstrate that each type of interlock goes along with unique knowledge-based, social influence-related, and institutional benefits and costs. We frame tie choice as a strategic decision based on a cost–benefit analysis and suggest that the tie-specific benefits and costs lead to the three types of ties not being equal alternatives. Appealing to specific motives for tie creation, these benefits and costs influence firms’ choice between the three types of interlocks. Our synthesis and cost–benefit analysis contribute to prior research by shedding light on the role of tie heterogeneity as a driver of tie creation as opposed to a factor causing firm-level outcomes. By focusing on content of ties, we extend the typically purely structural research on interlocking directorate networks. We suggest directions for future research and discuss possibilities to empirically validate our propositions on how tie-specific opportunities and constraints will affect tie choice.
ABO-phenotype protected reproduction as it is based on fucosylations
Creators: name: Arend, Peter
Publisher: name: figshare
Year: 2015
Subjects: subject: Hematology
subject: Medicine
subject: Biochemistry
subject: Cancer
subject: Biological Techniques
subject: Immunology
subject: FOS: Clinical medicine
subject: Computational Chemistry
subject: Molecular Biology
subject: Stem Cells
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Anatomy

description: Blood group ABO phenotype formation and innate IgM specificities
Development of Instructional Model Using Problem-Based Learning with Lateral Thinking on Isometric Virtual World to Enhance Creative Problem-Solving of the Undergraduate Students
Creators: name: Peerapat Chatsuwan
Publisher: name: Klungnana Vitthaya Press
Year: 2020
Subjects: Problem-based learning, Lateral thinking, Isometric Virtual World, Creative problem-solving

description: Journal of Information Science, 38, 1, 1-19
Ontological approach towards E-business process automation
Creators: name: Wu, Baolin
name: Li, Li
name: Yang, Yun
Publisher: name: Swinburne
Year: 2024

description: This paper discusses the interoperability of e-business processes by using an ontology approach with description logic and agent systems to achieve e-business automation. An innovative e-business process modeling framework is proposed that outlines the building blocks required for Internet-based e-business in order to enable e-business process automation. The framework helps in understanding the role of many proposed standards with respect to the building blocks and in identifying both overlaps and gaps among them. The domain knowledge of e-business processes is conceptualised as an e-business process ontology that enables agents’ communication in e-business application sharing and reusing. Several agent-based automation mechanisms are discussed based on the ontology that provides implementation guidelines to e-business process automation.
НОТЎЛИҚ ОИЛАЛАРДАГИ БОЛАЛАРДА ШАХСИЙ МАСЪУЛИЯТ ВА ЭМПАТИЯ ҲИССИНИ ШАКЛЛАНТИРИШНИНГ ИЖТИМОИЙ ТАРБИЯ ЙЎЛЛАРИ
Creators: name: Сафонова, Раьно
Publisher: name: Zenodo
Year: 2025

description: Мазкур мақолада нотўлиқ оилаларда ўсган болаларда шахсий масъулият ва эмпатия ҳиссини шакллантириш масаласи ижтимоий-педагогик нуқтаи назардан таҳлил қилинган. Ота ёки онасиз муҳитда вояга етаётган болаларда руҳий ҳимоясизлик, ҳиссий номувозанатлик ва ижтимоий муносабатлардаги муаммолар кузатилиши таъкидланган. Шунингдек, мактаб, маҳалла, оммавий ахборот воситалари, болалар марказлари ва нодавлат ташкилотларнинг тарбиявий ролини кучайтириш орқали бундай болаларда шахсий камолотни таъминлаш механизмлари таклиф этилган. Хорижий тажрибаларга асосланиб, миллий шароитга мос амалий ечимлар баён этилган.
Reciprocal Associations Between Parental Monitoring Knowledge and Impaired Driving in Adolescent Novice Drivers
Creators: name: Kaigang Li
name: Simons-Morton, Bruce G.
name: Vaca, Federico E.
name: Hingson, Ralph
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objective: Adolescent driving while alcohol/drug impaired (DWI) and parental monitoring knowledge may have notable interplay. However, the magnitude and direction of causality are unclear. This study examined possible reciprocal associations among adolescents between DWI and parental monitoring knowledge. Methods: The data were from waves 1, 2, and 3 (W1, W2, and W3) of the NEXT Generation Health Study, with longitudinal assessment of a nationally representative sample of 10th graders starting in 2009–2010 (n = 2,525 at W1) and analyzed in 2014. Those who had obtained an independent/unsupervised driving license were included for the analysis. Autoregressive cross-lagged path analysis was used to examine potential reciprocal associations between DWI and parental monitoring knowledge of both mothers and fathers, controlling for potential confounders. Results: Stability of fathers’ and mothers’ monitoring knowledge across 3 consecutive interview waves was identified. W1 monitoring knowledge of both fathers and mothers was prospectively associated with DWI at W2 but not for W2 with W3. A significant negative association between adolescent DWI at W2 and mothers’ monitoring knowledge at W3 was found but not between W1 and W2. None of the associations between DWI and fathers’ monitoring knowledge from W1 to W2 or from W2 to W3 were significant. Conclusions: Early (10th grade) parental monitoring knowledge may predict lower adolescent self-reported DWI in 11th grade. More notably, adolescent DWI did not seem to increase parental monitoring knowledge. Future interventions are needed to improve parental monitoring knowledge and enhance awareness of the DWI risk in their adolescent novice drivers.
The U.S.-China Phase One Trade Agreement: Implications for U.S. Forestry
Creators: name: Muhammad, Andrew
name: Smith, S. Aaron
name: Muhammad, Andrew
name: Smith, S. Aaron
Publisher: name: Unknown
Year: 2020
Subjects: subject: Demand and Price Analysis
subject: International Relations/Trade
subject: Land Economics/Use
subject: China
subject: forestry
subject: tariffs
subject: trade
subject: agreement
subject: United
subject: States

description: On January 15, 2020, the U.S. and China signed a “Phase One” trade deal to address desired structural reforms and other changes to the Chinese economy affecting international trade and foreign investment. The U.S.-China Phase One Trade Agreement, which is the first agreement in what is expected to be a series of agreements, focuses on reforms in the Chinese economy in the areas of intellectual property, technology transfer, agriculture, financial services, and currency and foreign exchange. The agreement also includes commitments by China to purchase additional U.S. goods over the next two years, including significant purchases of U.S. agricultural, food, fish and forest products (USTR, 2020a). Although the U.S. has agreed not to impose additional tariffs on imports from China, and China has agreed to reduce or eliminate certain tariffs imposed in retaliation, the Phase One Agreement does not specifically address the escalating tariffs between the two countries due to the ongoing trade dispute that started in 2018. However, the agreement signifies a decrease in tensions and a possible path to tariff reductions and eliminations in the future. This is particularly important for U.S. forest product exports, which suffered significant losses in 2018 and 2019 from Chinese retaliatory tariffs. In this report, we provide the context and overview of the U.S.-China Phase One Trade Agreement and implications for U.S. forest product exports. Forest products are a major agricultural and agriculture-related export for the U.S. However, the negative impact of the trade dispute on the sector has received little attention compared to other agricultural commodities such as soybeans and cotton. Over the last decade, the sector has become increasingly reliant on China for sales and suffered considerable losses from the retaliatory tariffs that China imposed (Ward, 2019; Pryor, 2019). The U.S.-China Phase One Trade Agreement sets the stage for a decrease in tensions between the two countries and the eventual removal of Chinese tariffs on U.S. products. This could result in considerable gains for the U.S. forest product sector moving forward.
Reciprocal Associations between Parental Monitoring Knowledge and Impaired Driving in Adolescent Novice Drivers
Creators: name: Kaigang Li
name: Simons-Morton, Bruce G.
name: Vaca, Federico E.
name: Hingson, Ralph
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Science Policy
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Medicine
subject: Engineering

description: Objective: Adolescent driving while alcohol/drug impaired (DWI) and parental monitoring knowledge may have notable interplay. However, the magnitude and direction of causality are unclear. This study examined possible reciprocal associations among adolescents between DWI and parental monitoring knowledge. Methods: The data were from waves 1, 2 and 3 (W1, W2 and W3) of the NEXT Generation Study, with longitudinal assessment of a nationally representative sample of 10th graders starting in 2009–2010 (n = 2,525 at W1) and analyzed in 2014. Those who had obtained an independent/unsupervised driving license were included for the analysis. Autoregressive cross-lagged path analysis was used to examine potential reciprocal associations between DWI and parental monitoring knowledge of both mothers and fathers, controlling for potential confounders. Results: Stability of fathers’ and mothers’ monitoring knowledge across three consecutive interview waves was identified. W1 monitoring knowledge of both fathers and mothers was prospectively associated with DWI at W2, but not for W2 with W3. A significant negative association between adolescent DWI at W2 and mother's monitoring knowledge at W3 was found, but not between W1 and W2. None of the associations between DWI and father's monitoring knowledge from W1 to W2, and from W2 to W3 were significant. Conclusions: Early (10th grade) parental monitoring knowledge may predict lower adolescent self-reported DWI in 11th grade. More notably, adolescent DWI did not seem to increase parental monitoring knowledge. Future interventions are needed to improve parental monitoring knowledge and enhance awareness of the DWI risk in their adolescent novice drivers.
Iracema Triques 1996
Creators: name: Carvalho, Tiago P.
name: Albert, James S.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Gymnotiformes
Rhamphichthyidae
Iracema

description: Iracema Triques, 1996 Type species. Iracema caiana Triques, 1996a: 91 by original designation and monotypy. Diagnosis. Iracema is distinguished from other rhamphichthyids by the following characteristics: 240-257 analfin rays (vs. 139-211 in Gymnorhamphichthys and 304-470 in Rhamphichthys); 15 or 16 pectoral-fin rays (vs. 10-13 in Gymnorhamphichthys and 17-22 in Rhamphichthys); a series of dark, rounded pigment blotches on the side of the body along the lateral line (vs. no pigmentation in Gymnorhamphichthys and dark oblique transverse bands or no pigmentation in Rhamphichthys); caudal filament ovoid in cross section, its depth slightly greater than its width (vs. caudal filament laterally compressed in cross section, its depth about three times its width in Gymnorhamphichthys and Rhamphichthys).
description: Published as part of Carvalho, Tiago P. & Albert, James S., 2011, Redescription and phylogenetic position of the enigmatic Neotropical electric fish Iracema caiana Triques (Gymnotiformes: Rhamphichthyidae) using x-ray computed tomography, pp. 457-469 in Neotropical Ichthyology 9 (3) on pages 458-459, DOI: 10.1590/S1679-62252011000300001, http://zenodo.org/record/5422881
Pre-reclamation in situ testing of soft soil
Creators: name: Arulrajah, Arul
name: Bo, M. W.
name: Nikraz, H.
name: Hashim, R.
Publisher: name: Swinburne
Year: 2024

description: The Changi East Reclamation Project in the Republic of Singapore comprises the ground improvement of marine clay with the installation of prefabricated vertical drains and subsequent preloading. Prior to the commencement of land reclamation works, a series of in situ tests were conducted under marine conditions with the help of various in situ testing equipment. The In Situ Testing Site was located in the northern part of the project where the thickest compressible marine clay existed. The in situ tests carried out were with the field vane, piezocone, flat dilatometer, self-boring pressuremeter and BAT permeameter. In situ tests were conducted to determine the undrained shear strength, overconsolidation ratio, soil stiffness and coefficient of consolidation and permeability of the marine clay. In situ dissipation tests provide a means of evaluating the in situ coefficient of consolidation and hydraulic conductivity due to horizontal flow of soft soil and were used to estimate these properties of Singapore marine clay at Changi.
Electrochemically Induced N-Alkylation of Chiral 2-(Methylsulfinyl) 1H-Benzimidazole
Creators: name: Capobianco, Amedeo
name: Caruso, Tonino
name: Palombi, Laura
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Evolutionary Biology
subject: Pharmacology
subject: Molecular Biology
subject: Cell Biology

description: Galvanostatic electrolysis of chiral 2-(methylsulfinyl) 1H-benzimidazole in an acetonitrile/tetraethyl ammonium tetrafluoroborate system has been exploited to carry out the selective N-alkylation of the benzimidazole moiety with organohalides, thus obtaining chiral derivatives with potential use in drug research. Theoretical determination of the redox potential for the title compound has been effected, and plausible pathways for its electroactivation have been described. Furthermore, by means of this electrochemical strategy, the access to enantioenriched N-alkylated 2-(methylsulfinyl)benzimidazole has been established.
ABO phenotype protected reproduction as it is based on fucosylations
Creators: name: Arend, Peter
Publisher: name: figshare
Year: 2015
Subjects: subject: Hematology
subject: Medicine
subject: Biochemistry
subject: Cancer
subject: Biological Techniques
subject: Immunology
subject: FOS: Clinical medicine
subject: Computational Chemistry
subject: Molecular Biology
subject: Stem Cells
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Anatomy

description: Blood group ABO phenotype formation and innate IgM specificities
Density fingerprint of giant vortices in Fermi gases near a Feshbach resonance
Creators: name: Hu, Hui
name: Liu, Xiaji
Publisher: name: Swinburne
Year: 2024

description: The structure of multiply quantized or giant vortex states in atomic Fermi gases across a Feshbach resonance is studied within the context of self-consistent Bogoliubov-de Gennes theory. The particle density profile of vortices with K > 1 flux quanta is calculated. Owing to K discrete branches of vortex-core bound states, inside the core the density oscillates as a function of the distance from the vortex line and displays a nonmonotoic dependence on the interaction strengths, in marked contrast to the singly quantized case, in which the density depletes monotonically. This feature can make a direct visualization of the giant vortices in atomic Fermi gases.
BCS-BEC crossover in an asymmetric two-component Fermi gas
Creators: name: Liu, Xiaji
name: Hu, Hui
Publisher: name: Swinburne
Year: 2024

description: We discuss the superfluid phase transition of a strongly interacting Fermi gas with unequal (asymmetric) chemical potentials in two pairing hyperfine states, and map out its phase diagram near the BCS-BEC crossover. Our approach includes the fluctuation contributions of 'preformed Cooper pairs' to the thermodynamic potential at finite temperature. We show that, below a critical difference in chemical potentials between species, a normal gas is unstable towards the formation of either a finite-momentum paired Fulde-Ferrell-Larkin-Ovchinnikov superconducting phase or a uniform superfluid, depending on the asymmetry and interaction strengths. We determine the value of critical chemical potential mismatch, and find that it is consistent with a recent measurement by Zwierlein et al. (Science, 311 (2006) 492).
Inhibition analysis studies involving biotin and folic acid
Creators: name: Rogers, Lorene Lane, 1914-
Publisher: name: The University of Texas at Austin
Year: 1948
Subjects: subject: Chemistry, Analytic
subject: Biotin
subject: Folic acid

description: In the present investigation the methods of inhibition analysis have been applied in an effort to elucidate the function and biosynthesis of biotin and the function of folic acid
description: In the present investigation the methods of inhibition analysis have been applied in an effort to elucidate the function and biosynthesis of biotin and the function of folic acid
Syntheses of Novel Triphenylene-Aminoanthraquinone Dimers and Studies on Their Mesomorphic and Fluorescence Properties
Creators: name: Mingguang Zhu
name: Fafu Yang
name: Hongyu Guo
name: Congcong Li
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Physics
subject: 60506 Virology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Cell Biology
subject: Engineering
subject: Biochemistry
subject: Biophysics

description: Two novel triphenylene-aminoanthraquinone dimers 4a and 4b were synthesized by reacting triphenylene carboxyl derivatives 3a or 3b with 2-aminoanthracene-9,10-dione in yields of 80% and 78%, respectively. Their structures were confirmed by 1H NMR, electrospray ionization (ESI-MS), and elemental analysis. Their mesomorphic properties were studied by diffraction scanning calorimetry (DSC), polarizing optical microscopy (POM), and x-ray diffraction (XRD). The mesomorphic results suggested that they possess excellent mesophase properties. The investigation of fluorescence properties indicated that the strong cooperating fluorescence actions exist between two structural units. The fluorescence of dimers 4a and4b are seriously quenched due to the electron transfer from donor (triphenylene unit) to acceptor (aminoanthraquinone unit).