title: Design and Development of Magnetoelectric Multilayer Capsules for Enhanced Intracellular Drug Release: an Innovative Strategy for Improving Cancer Treatment Efficacy
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: ÐÐ¸Ð·Ð°Ð¹Ð½ Ð¸ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¼Ð°Ð³Ð½Ð¸ÑÐ¾ÑÐ»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¼Ð½Ð¾Ð³Ð¾ÑÐ»Ð¾Ð¹Ð½ÑÑ ÐºÐ°Ð¿ÑÑÐ» Ð´Ð»Ñ ÑÑÐ¸Ð»ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð²Ð½ÑÑÑÐ¸ÐºÐ»ÐµÑÐ¾ÑÐ½Ð¾Ð³Ð¾ Ð²ÑÑÐ²Ð¾Ð±Ð¾Ð¶Ð´ÐµÐ½Ð¸Ñ Ð»ÐµÐºÐ°ÑÑÑÐ²: Ð¸Ð½Ð½Ð¾Ð²Ð°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÑÑÐ°ÑÐµÐ³Ð¸Ñ Ð¿Ð¾Ð²ÑÑÐµÐ½Ð¸Ñ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð»ÐµÑÐµÐ½Ð¸Ñ ÑÐ°ÐºÐ°
Creators: name: ÐÐ¾ÑÑÐ¸, ÐÐ¹Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2023
Subjects: ÐÐ¸Ð¾ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸Ñ
Ð¼Ð°Ð³Ð½Ð¸ÑÐ¾ÑÐ»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð¼Ð½Ð¾Ð³Ð¾ÑÐ»Ð¾Ð¹Ð½ÑÐµ ÐºÐ°Ð¿ÑÑÐ»Ñ
Ð´Ð¾ÑÑÐ°Ð²ÐºÐ° Ð»ÐµÐºÐ°ÑÑÑÐ²
ÑÑÐ±Ð¼Ð¸ÐºÑÐ¾ÑÐ°ÑÑÐ¸ÑÑ
Ð½Ð°Ð½Ð¾ÑÐ°ÑÑÐ¸ÑÑ
Ð»ÐµÑÐµÐ½Ð¸Ðµ ÑÐ°ÐºÐ°
Ñ Ð¸Ð¼Ð¸Ð¾ÑÐµÑÐ°Ð¿Ð¸Ñ
Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ Ð¼Ð°Ð³Ð½Ð¸ÑÐ½Ð¾Ð³Ð¾ Ð¿Ð¾Ð»Ñ
Ð¿ÑÐµÐ·Ð¾ÑÐ»ÐµÐºÑÑÐ¸ÑÐµÑÐºÐ°Ñ Ð¾Ð±Ð¾Ð»Ð¾ÑÐºÐ°
magnetoelectric multilayer capsules
drug delivery
sub microparticles
nanoparticles
cancer treatment
chemotherapy
magnetic field exposure
piezoelectric shell

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description: The given work is devoted to improving the current cancer treatment methods that cause severe side effects and are often ineffective such as chemotherapy due to poor drug delivery to the tumor site, to address this issue, magnetoelectric multilayer capsules have been developed as an innovative approach for targeted and controlled intracellular delivery of doxorubicinThe capsules consist of a magnetic layer, a piezoelectric layer, and a polyelectrolyte layer containing the drug, the magnetic layer allows for external magnetic field guidance, while the piezoelectric layer responds to the magnetic field and generates mechanical stress to induce drug release. The capsules were successfully synthesized and characterized using various analytical techniques, Tasks to be solved during the project: 1. Developing novel synthesis methods that enable the sequential inclusion of Magnetoelectric nanoparticles (MEMs) within magnetoelectric multilayer capsules (MEMCS). 2. Characterization of the obtained magnetoelectric multilayer capsules (MEM-CAPs) using physio-chemical methods. 3. Investigate the potential of magnetoelectric multilayer capsules (MEMCs) for targeted and controlled release of doxorubicin (Dox) in cancer cells. 4. Investigate the potential toxic effects and impact on cell growth of the developed multilayer capsules through in vitro studies on cell lines The work was carried out based on Skolkovo institute of science and technology and SPbPU, where most of the work was performed: the development of protocol for the synthesis of all particles and capsules, in vitro experiments, and all characterization of magnetoelectric nanoparticles and magnetoelectric multilayer capsules except ferroelectric and ferromagnetic analysis, the results showed that the capsules were able to control the target cancer cells and release the drug in a controlled manner, resulting in improved cytotoxicity compared to free doxorubicin. This approach has the potential to revolutionize cancer treatment by providing an effective and targeted drug delivery system that minimizes side effects and improves treatment outcomes.