Additional file 1 of Effects of preoperative high-oral protein loading on short- and long-term renal outcomes following cardiac surgery: a cohort study
Creators: name: Husain-Syed, Faeq
name: Emlet, David R.
name: Wilhelm, Jochen
name: Danesi, Tommaso Hinna
name: Ferrari, Fiorenza
name: Bezerra, Pércia
name: Lopez-Giacoman, Salvador
name: Villa, Gianluca
name: Tello, Khodr
name: Birk, Horst-Walter
name: Seeger, Werner
name: Giavarina, Davide
name: Salvador, Loris
name: Fuhrman, Dana Y.
name: Kellum, John A.
name: Ronco, Claudio
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Marine Biology

description: Additional file 1: Figure S1. Study flow chart. The diagram describes the protocol used for the enrolment of patients in the present study. ACEis, angiotensin-converting-enzyme inhibitors; ARB, angiotensin II receptor blockers; IV, intravenous; NSAIDs, non-steroidal anti-inflammatory drugs. Figure S2. Changes in eGFR among patients receiving high oral protein loading compared to those receiving standard care prior to cardiac surgery. The figure illustrates the changes in eGFR among patients receiving preoperative high oral protein loading (dark-grey circles), as compared to those in patients receiving standard care (light-grey circles) at different time points (a) and compared to the preoperative values (b). Horizontal lines indicate median values, boxes indicate the inter-quartile range, and whiskers indicate the minimum and maximum values. Data beyond the whiskers are plotted as outliers (circles). The number of patients in each group at different time points for each group are presented in parentheses. eGFR, estimated glomerular filtration rate. Figure S3. Serum creatinine levels among patients receiving high oral protein loading compared to those receiving standard preoperative care prior to cardiac surgery. (a) Serum creatinine levels at the time of admission as well at 3 and 12 months after surgery. (b) Change in serum creatinine levels relative to the time of admission. Light grey: patients with standard preoperative care; dark grey: patients receiving preoperative high oral protein loading. Points are mean values with error bars indicating the 95% confidence intervals. The number of patients in each group at different time points for each group are presented in parentheses. Figure S4. Serum creatinine levels categorized by the occurrence of AKI and AKI reversal at hospital discharge among patients receiving preoperative high oral protein loading compared to those receiving standard preoperative care. (a) Serum creatinine levels at the time of admission as well at 3 and 12 months after surgery. (b) Change in serum creatinine levels, relative to the time of admission. Light grey: patients with standard preoperative care; dark grey: patients receiving preoperative high oral protein loading. Number of patients at different time points for each group are presented in parentheses. AKI, acute kidney injury. Table S1. Bioimpedance vector analysis of the protein loading group categorized by occurrence of postoperative AKI. Table S2. Baseline, operative, ICU and follow-up characteristics categorized by occurrence of AKI. Table S3. Serum creatinine levels among patients receiving high oral protein loading, as compared to those in patients receiving standard care prior to cardiac surgery.