cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Metabolic N-hydroxylation of pentamidine in vitro.
Creators: name: Lombardy, R J
name: Berger, B J
name: Dykstra, C C
name: Bell, C A
name: Marbury, G D
name: Hall, J E
name: Tidwell, R R
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: By using high-performance liquid chromatography, the in vitro conversion of pentamidine to the corresponding amidoximes (N-hydroxypentamidine and N,N'-dihydroxypentamidine) was studied in supernatants of rat liver homogenate centrifuged at 9,000 x g. The presence of the two amidoxime peaks in chromatograms was confirmed by liquid secondary ion mass spectrometry and by unequivocal synthesis of the suspected metabolites. The metabolic reactions were found to be catalyzed by the cytochrome P-450 system (mixed-function oxidases). The formation of the monohydroxylated product was found to have a Km of 0.48 mM and a Vmax of 29.50 pmol/min per mg of protein, while the dihydroxylated metabolite had a Km of 0.73 mM and a Vmax of 4.10 pmol/min per mg of protein. N,N'-Dihydroxypentamidine was found to have highly reduced antiprotozoal activity in vitro relative to that of pentamidine, and neither of the hydroxylated metabolites nor pentamidine was found to be significantly mutagenic by the Ames test. Contrary to previous reports, pentamidine is readily metabolized to at least two hydroxylated products, and this conversion may be relevant to the clinical use of the compound and to future drug design.
1480-4108-1-PB (1).pdf
Creators: name: Hamson, Zulkarnain
Publisher: name: figshare
Year: 2019
Subjects: subject: 200202 Asian Cultural Studies
subject: FOS: Other humanities
subject: 200101 Communication Studies
subject: FOS: Media and communications

description: AISI menjadi organisasi instruktur yang terus memperbarui integritas anggotanya
Novel pentamidine analogs in the treatment of experimental Pneumocystis carinii pneumonia.
Creators: name: Ohemeng, K A
name: Allen, M A
name: Hall, J E
name: Jones, S K
name: Reddy, V V
name: Tidwell, R R
name: Geratz, J D
name: Morrison, S D
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: We have recently demonstrated that substitution of imidazoline moieties for the amidine groups of pentamidine produces a molecule that is effective against rat Pneumocystis carinii pneumonia and that is apparently less toxic than pentamidine. For this reason, 10 novel imidazoline substituted compounds were evaluated for their effect against rat P. carinii pneumonia. While several of the new compounds were observed to have advantages over pentamidine in the treatment of disease in the rat model, only one compound stood out as a potential new clinical agent. Treatment for 2 weeks with intravenous (i.v.) doses of 1,3-di(4-imidazolino-2-methoxyphenoxy)propane (DIMP) at 1 mg/kg per day produced an anti-P. carinii pneumonia effect equivalent to i.v. doses of pentamidine at 10 mg/kg per day. Although pentamidine and one of the test drugs, 1,3-di(4-imidazolinophenoxy)propane, showed no activity against P. carinii pneumonia when administered per os, DIMP exhibited potent anti-P. carinii pneumonia activity when given by daily gavage doses of 40 and 25 mg/kg. DIMP retained significant activity when given every other day by a gavage dose of 25 mg/kg. No toxicity was observed with the drug at any of the dose levels or by either of the routes of administration. However, the low solubility of the drug prevented testing at higher i.v. doses. Our conclusion is that DIMP has the potential of providing a safer and more effective alternative to pentamidine for the treatment of P. carinii pneumonia.
Classification of holomorphic foliations on Hopf manifolds
Creators: name: Corrêa, Maurício
name: Fernández-Pérez, Arturo
name: Ferreira, Antonio M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Geometry (math.AG)
subject: Complex Variables (math.CV)
subject: Differential Geometry (math.DG)
subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics

description: We classify nonsingular holomorphic foliations of dimension and codimension one on certain Hopf manifolds. More general, we prove that all nonsingular codimension one distributions on intermediary or generic Hopf manifolds are integrable and has holomorphic integral first. Also, we prove some results about singular holomorphic distributions on Hopf manifolds.
description: 13 pages, to appear Mathematische Annalen
The rationale for MET and EqT, and how they differ from NHST from Null regions: a unified conceptual framework for statistical inference
Creators: name: Smiley, Adam H.
name: Glazier, Jessica J.
name: Shoda, Yuichi
Publisher: name: The Royal Society
Year: 2023
Subjects: Statistics not elsewhere classified

description: Ruling out that there is absolutely no effect or association between variables may be a good first step, but it is rarely the ultimate goal of science. Yet that is the only inference provided by traditional null hypothesis significance testing (NHST), which has been a mainstay of many scientific fields. Reliance on NHST also makes it difficult to define what it means to replicate a finding, and leads to an uncomfortable quandary in which increasing precision in research reduces researchers' ability to perform theory falsification. To solve these problems, in recent years several alternatives to traditional NHST have been proposed. Yet few researchers are familiar with these alternatives because each new test is described using its own terminology and practiced in different fields. We describe a simple, unified framework for conceptualizing all these tests so that it is not necessary to learn them separately. Moreover, the framework allows researchers to conduct any of these tests by asking just one question: is the confidence interval entirely outside the null region(s)? This framework may also help researchers choose the test(s) that best answers their research question when simply ruling out ‘no effect at all’ is not enough.
100 AÑOS DE FRASES PUBLICITARIAS: CARACTERIZACIÓN DEL TEXTO PUBLICITARIO EN LA REVISTA CROMOS EN COLOMBIA
Creators: name: Aguilera, Pedro Pablo
name: Jhon Jairo León Muñoz
Publisher: name: Figshare
Year: 2019
Subjects: subject: 120307 Visual Communication Design (incl. Graphic Design)
subject: FOS: Arts (arts, history of arts, performing arts, music)
subject: 200526 Stylistics and Textual Analysis
subject: FOS: Languages and literature
subject: 200205 Culture, Gender, Sexuality
subject: FOS: Other humanities
subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications

description: Un análisis de la evolución, condicionantes y recursos del texto publicitario en la Revista Cromos. Este texto es un capítulo de un libro
Pharmacokinetics of cefepime in patients with respiratory tract infections.
Creators: name: Deenstra, M
name: Verhoef, J
name: Hart, H C
name: Hoepelman, I M
name: Rademaker, C M
name: Kovarik, J M
name: ter Maaten, J C
name: Matzke, G R
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: The steady-state pharmacokinetics of cefepime were evaluated in 10 middle-aged and elderly patients with acute lower respiratory tract infections who were receiving 1 g intravenously every 12 h. One preinfusion and 15 postinfusion serum samples and total urine output were collected over one dosing interval between days 3 and 8 of therapy. Cefepime concentrations in serum over time exhibited a multicompartmental profile. Peak and trough concentrations in serum determined by a validated high-performance liquid chromatography method were 71.2 +/- 17.2 (mean +/- standard deviation) and 6.0 +/- 4.9 mg/liter, respectively. The steady-state volume of distribution was 0.22 +/- 0.05 liter/kg. Elimination half-lives ranged from 1.93 to 6.04 h (3.92 +/- 1.28 h), and total body clearances ranged from 36.9 to 102 ml/min per 1.73 m2 (73.0 +/- 19.7 ml/min per 1.73 m2). The disposition of cefepime at steady state in patients was comparable to previous observations in healthy elderly volunteers. The predictive performance of regression equations derived from single-dose studies in volunteers relating creatinine clearance with total body and renal clearances of cefepime exhibited slight biases (mean predictive errors, -9.7 and 2.1 ml/min per 1.73 m2, respectively) and similar precisions. Predicted and observed total body clearances (63.3 +/- 25.1 versus 73.0 +/- 19.7 ml/min per 1.73 m2, respectively) and renal clearances (51.3 +/- 24.4 versus 49.3 +/- 19.6 ml/min per 1.73 m2, respectively) were not significantly different. The pharmacokinetics of cefepime in infected patients appeared to be unaltered by illness, and the steady-state disposition of cefepime was predictable from data derived from single-dose studies in volunteers.
Annular substructures in the transition disks around LkCa 15 and J1610
Creators: name: Ansdell, M.
name: Loomis, R.
name: Mayama, S.
name: Pinilla, P.
name: Facchini, S.
name: Perez, L.
name: Benisty, M.
name: Isella, A.
name: Mann, A.
name: Teague, R.
name: Bae, J.
Publisher: name: EDP Sciences
Year: 2020

description: We present high-resolution millimeter continuum ALMA observations of the disks around the T Tauri stars LkCa 15 and 2MASS J16100501-2132318 (hereafter, J1610). These transition disks host dust-depleted inner regions, which have possibly been carved by massive planets, and they are of prime interest to the study of the imprints of planet-disk interactions. While at moderate angular resolution, they appear as a broad ring surrounding a cavity, the continuum emission resolves into multiple rings at a resolution of ~60 × 40 mas (~7.5 au for LkCa 15, ~6 au for J1610) and ~7 μJy beam-1 rms at 1.3 mm. In addition to a broad extended component, LkCa 15 and J1610 host three and two narrow rings, respectively, with two bright rings in LkCa 15 being radially resolved. LkCa 15 possibly hosts another faint ring close to the outer edge of the mm emission. The rings look marginally optically thick, with peak optical depths of ~0.5 (neglecting scattering), in agreement with high angular resolution observations of full disks. We performed hydrodynamical simulations with an embedded, sub-Jovian-mass planet and show that the observed multi-ringed substructure can be qualitatively explained as the outcome of the planet-disk interaction. We note, however, that the choice of the disk cooling timescale alone can significantly impact the resulting gas and dust distributions around the planet, leading to different numbers of rings and gaps and different spacings between them. We propose that the massive outer disk regions of transition disks are favorable places for planetesimals, and possibly second-generation planet formation of objects with a lower mass than the planets carving the inner cavity (typically few MJup), and that the annular substructures observed in LkCa 15 and J1610 may be indicative of planetary core formation within dust-rich pressure traps. Current observations are compatible with other mechanisms contributing to the origin of the observed substructures, in particular with regard to narrow rings generated (or facilitated) at the edge of the CO and N2 snowlines.
1499-4225-1-PB (2).pdf
Creators: name: Hamson, Zulkarnain
Publisher: name: figshare
Year: 2019
Subjects: subject: 160503 Communications and Media Policy
subject: FOS: Political science
subject: 169903 Studies of Asian Society
subject: FOS: Sociology

description: The term communication pattern is commonly referred to as a model but the intention is the same, namely a system consisting of various components related to each other to achieve goals. Communication patterns in the community can be used as a way t o e x a m i n e t h e a p p l i c a t i o n o f c o m m u n i c a t i o n t h a t i s b u i l t a n d r u n n i n g , a l s o characterizes the life of the organization. Many activities are carried out to identify how communication patterns can be applied in the community. An understanding of what is meant by communit y is needed. Community definition is a group of people who are members of a forum or organization that has a specific purpose because of the same background of interest. In the community there is an interaction process. Community Service Activities (PKM) a ims to provide knowledge as well as direction, to adolescents who are members of the Makassar Literacy Addict Community, in order to help them recognize health literacy, which has been a reading, and also know how communication patterns are formed within t he community
Structure-activity relationships of analogs of pentamidine against Plasmodium falciparum and Leishmania mexicana amazonensis.
Creators: name: Ohemeng, K A
name: Tidwell, R R
name: Kyle, D E
name: Allen, M A
name: Grogl, M
name: Hall, J E
name: Bell, C A
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: The antiprotozoal compound 1,5-di(4-amidinophenoxy)pentane (pentamidine) and 36 of its analogs were screened for in vitro activity against Leishmania mexicana amazonensis clone 669 C4S (MHOM/BR/73/M2269) and Plasmodium falciparum clones W2 (Indochina III/CDC) and D6 (Sierra Leone I/CDC). Pentamidine and each of the analogs tested exhibited activity in vitro against L. m. amazonensis and P. falciparum. The pentamidine analogs were more effective against the P. falciparum clones than against L. m. amazonensis. P. falciparum was extremely susceptible to these compounds, with 50% inhibitory concentrations as low as 0.03 microM. While none of the analogs exhibited marked improvement in antileishmanial activity compared with pentamidine, 12 of the pentamidine analogs showed activity approximately equal to or greater than that of the parent compound. From the promising activity exhibited by the pentamidine analogs in this in vitro study and their potential for reduced toxicity relative to the parent drug, pentamidine-related compounds hold promise as new agents for the treatment of protozoal infections.
Activity of pentamidine and pentamidine analogs against Toxoplasma gondii in cell cultures.
Creators: name: Blagburn, B L
name: Lindsay, D S
name: Hall, J E
name: Tidwell, R R
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: The capabilities of pentamidine and nine pentamidine analogs to inhibit the development of Toxoplasma gondii were examined in vitro. Treatment of infected cultures with pentamidine and five of its analogs caused a significant (P less than 0.05) reduction in the numbers of tachyzoites produced. Analogs of pentamidine may be useful agents in the treatment of toxoplasmosis.
$D_{sJ}(2860)$ From The Semileptonic Decays Of $B_s$ Mesons
Creators: name: Gan, Long-Fei
name: Zhang, Jian-Rong
name: Huang, Ming-Qiu
name: Zhuo, Hong-Bin
name: Ma, Yan-Yun
name: Zhu, Qing-Jun
name: Liu, Jian-Xun
name: Zhang, Guo-Bo
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In the framework of heavy quark effective theory, the leading order Isgur-Wise form factors relevant to semileptonic decays of the ground state $\bar{b}s$ meson $B_{s}$ into orbitally excited $D$-wave $\bar{c}s$ mesons, including the newly observed narrow $D^{*}_{s1}(2860)$ and $D^{*}_{s3}(2860)$ states by the LHCb Collaboration, are calculated with the QCD sum rule method. With these universal form factors, the decay rates and branching ratios are estimated. We find that the decay widths are $Γ(B_s\rightarrow D^{*}_{s1}\ell\barν) =1.25^{+0.80}_{-0.60}\times10^{-19} \mbox{GeV}$, $Γ(B_s\rightarrow D^{'}_{s2}\ell\barν) =1.49^{+0.97}_{-0.73}\times10^{-19} \mbox{GeV}$, $Γ(B_s\rightarrow D_{s2}\ell\barν) =4.48^{+1.05}_{-0.94}\times10^{-17} \mbox{GeV}$, and $Γ(B_s\rightarrow D^{*}_{s3}\ell\barν) = 1.52^{+0.35}_{-0.31}\times10^{-16} \mbox{GeV}$. The corresponding branching ratios are $\mathcal {B}(B_s\rightarrow D^{*}_{s1}\ell\barν) =2.85^{+1.82}_{-1.36}\times 10^{-7}$, $\mathcal {B}(B_s\rightarrow D^{'}_{s2}\ell\barν) =3.40^{+2.21}_{-1.66}\times 10^{-7}$, $\mathcal {B}(B_{s}\rightarrow D_{s2}\ell\barν) =1.02^{+0.24}_{-0.21}\times 10^{-4}$, and $\mathcal {B}(B_s\rightarrow D^{*}_{s3}\ell\barν) = 3.46^{+0.80}_{-0.70}\times 10^{-4}$. The decay widths and branching ratios of corresponding $B^{*}_{s}$ semileptonic processes are also predicted.
description: 13 pages, 4 figures. arXiv admin note: substantial text overlap with arXiv:1112.5227, arXiv:1009.0980
In vitro activity of orally administered antimicrobial agents against Haemophilus influenzae recovered from children monitored longitudinally in a group day-care center.
Creators: name: Gilligan, P H
name: Henderson, F W
name: George, M J
name: Kitch, B
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: To determine whether the prevalence of resistance to commonly used oral antimicrobial agents varied over time, we compared the in vitro susceptibilities of 217 strains of Haemophilus influenzae recovered from nasopharyngeal secretions of children in a day-care center studied longitudinally between 1979 and 1987. The overall rate of beta-lactamase production in these strains was 18%, with rates of 57% in type b isolates (n = 21) and 14% in non-type b isolates (n = 196). The percentages of isolates for which MICs were less than or equal to 1.0 micrograms/ml for amoxicillin alone, amoxicillin in combination with clavulanic acid, and cefuroxime alone were 82, 92, and 93%, respectively. The percentage of strains for which cefaclor MICs were less than or equal to 1.0 micrograms/ml was only 0.5%. Isolates for which chloramphenicol MICs were greater than 2.0 micrograms/ml or for which trimethoprim-sulfamethoxazole MICs were greater than 0.5/9.5 micrograms/ml were uncommon: 1 and less than 1%, respectively. High concentrations of erythromycin alone and in combination with sulfisoxazole were required to inhibit the majority of test strains; there was no evidence of erythromycin-sulfisoxazole synergy. In vitro susceptibility to commonly used oral antimicrobial agents remained at a constant level when H. influenzae isolates collected from children in a day-care center during 1979 through 1983 were compared with strains collected during 1984 through 1987.
Formulas for Rational-Valued Separability Probabilities of Random Induced Generalized Two-Qubit States
Creators: name: Slater, Paul B.
name: Dunkl, Charles F.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Mathematical Physics (math-ph)
subject: Probability (math.PR)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 81P45, 62E17

description: Previously, a formula, incorporating a $5F4$ hypergeometric function, for the Hilbert-Schmidt-averaged determinantal moments $\left\langle \left\vert ρ^{PT}\right\vert ^{n}\left\vert ρ\right\vert ^{k}\right\rangle /\left\langle \left\vert ρ\right\vert ^{k}\right\rangle$ of $4 \times 4$ density-matrices ($ρ$), and their partial transposes ($ρ^{PT}|$) was applied with $k=0$ to the generalized two-qubit separability-probability question. The formula can, further, be viewed we note here, as an averaging over "induced measures in the space of mixed quantum states". The associated induced-measure separability probabilities ($k =1, 2,\ldots$) are found--{\it via} a high-precision density approximation procedure--to assume interesting, relatively simple rational values in the two-re[al]bit ($α= \frac{1}{2}$), (standard) two-qubit ($α= 1$) and two-quater[nionic]bit ($α=2$) cases. We deduce rather simple companion (rebit, qubit, quaterbit,\ldots) formulas that successfully reproduce the rational values assumed for {\it general} $k$. These formulas are observed to share certain features, possibly allowing them to be incorporated into a single master formula.
description: 18 pages, 2 figures, revised version to appear in Advances in Mathematical Physics
Effectiveness Of Industrial Community Development Control With An Environmental Insight In South Sulawesi Province
Creators: name: Hamson, Zulkarnain
Publisher: name: figshare
Year: 2020
Subjects: subject: 200206 Globalisation and Culture
subject: FOS: Other humanities

description: Program pemberdayaan masyarakat yang dikemas dalam bentuk Tanggung Jawab Sosial Korporat (CSR) dengan Pengembangan Masyarakat (Comdev) untuk memberdayakan masyarakat lokal yang melakukan operasi perdamaian tanpa format kontrol yang jelas tidak menunjukkan pengaruh pengukuran dalam pembuatan dan penerapan program.
Ebay_data_AP.csv
Creators: name: Heinrich, Sarah
name: Ross, Joshua
name: Phill Cassey
Publisher: name: Figshare
Year: 2019
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: original Ebay dataset accompanying :

Heinrich S, Ross JV, Cassey P. Of cowboys, fish, and pangolins: US trade in exotic leather. Conservation Science and Practice.2019;e75. https://doi.org/10.1111/csp2.75
Cyclic Peptides Targeting SPSB Proteins as Potential Anti-Infective Agents
Creators: name: MAIADA MOHSEN MOHAMED SADEK HASSAN
Publisher: name: Monash University
Year: 2019
Subjects: subject: 30499 Medicinal and Biomolecular Chemistry not elsewhere classified
subject: FOS: Chemical sciences

description: Inhibition of the interaction between SPRY domain containing SOCS Box Proteins (SPSB) and inducible nitric oxide synthase (iNOS) increases iNOS levels and cellular NO, and has been proposed to kill intracellular pathogens. Inhibitors of this interaction were discovered previously. However, they cannot penetrate live cells to reach their target proteins. Herein, several potent inhibitors (cyclic peptides and cell penetrating peptide conjugates) were generated. The conjugates were promising in penetrating the cell membrane, although more work need to be done to confirm this. Hence, this study act as a significant step towards the development of SPSB-iNOS inhibitors as potential anti-infective agents
Sensitivity of gravitational waves from preheating to a scalar field's interactions
Creators: name: Hyde, Jeffrey M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: After inflation, a period of preheating may have produced a stochastic background of high frequency gravitational waves (GWs) that would persist until today. The nature of the inflaton's coupling to Standard Model or other fields is unknown, so it is useful to ask what features such fields may typically have, and how these affect predictions for the GW's produced. Here we consider the inflaton to be coupled to a light scalar field, and show that even a very small quartic self-interaction term will reduce the amplitude of the GW spectrum. For self-coupling $λ_χ \gtrsim g^2$, where $g^2$ is the inflaton-scalar coupling, the peak energy density goes as $Ω_{\rm gw}^{(λ_χ)} / Ω_{\rm gw}^{(λ_χ=0)} \sim (g^2/λ_χ)^{2}$. A consequence is that if the universe reheats through an inflaton-Higgs coupling then the spectrum would be suppressed but the dynamics would be sensitive to the Higgs potential near the energy scale of inflation.
description: 19 pages, 4 figures. Added Section V and some references. Version accepted by PRD
Inhibition of Cryptosporidium parvum in neonatal Hsd:(ICR)BR Swiss miceby polyether ionophores and aromatic amidines.
Creators: name: Hall, J E
name: Sundermann, C A
name: Lindsay, D S
name: Tidwell, R R
name: Blagburn, B L
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: Cryptosporidicidal effects of two polyether ionophores (maduramicin and alborixin), a fluorinated 4-quinolone (enrofloxacin), and three analogs of pentamidine were evaluated in a suckling mouse bioassay. Treatment with all compounds except enrofloxacin and one of the pentamidine analogs [1,3-di(4-imidazolinophenoxy)propane] resulted in significant (P less than 0.05) reductions in oocyst excretion.
The effective QCD phase diagram and the critical end point
Creators: name: Ayala, Alejandro
name: Bashir, Adnan
name: Cobos-Martinez, J. J.
name: Hernandez-Ortiz, Saul
name: Raya, Alfredo
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Lattice (hep-lat)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We study the QCD phase diagram on the plane of temperature T and quark chemical potential mu, modelling the strong interactions with the linear sigma model coupled to quarks. The phase transition line is found from the effective potential at finite T and mu taking into accounts the plasma screening effects. We find the location of the critical end point (CEP) to be (mu^CEP/T_c,T^CEP/T_c) sim (1.2,0.8), where T_c is the (pseudo)critical temperature for the crossover phase transition at vanishing mu. This location lies within the region found by lattice inspired calculations. The results show that in the linear sigma model, the CEP's location in the phase diagram is expectedly determined solely through chiral symmetry breaking. The same is likely to be true for all other models which do not exhibit confinement, provided the proper treatment of the plasma infrared properties for the description of chiral symmetry restoration is implemented. Similarly, we also expect these corrections to be substantially relevant in the QCD phase diagram.
description: 7 pages 3 figures; expanded discussion; added references; version to appear in Nucl. Phys. B
TOI-481 b and TOI-892 b: Two Long-period Hot Jupiters from the Transiting Exoplanet Survey Satellite
Creators: name: Zhang, H.
name: Mireles, I.
name: Bouchy, F.
name: Wright, D.J.
name: Jordán, A.
name: Vines, J.I.
name: Udry, S.
name: Segransan, D.
name: Kane, S.R.
name: Horner, J.
name: Ziegler, C.
name: Schlecker, M.
name: Shporer, A.
name: Yahalomi, D.A.
name: Wang, S.
name: Bryant, E.M.
name: Esquerdo, G.A.
name: Okumura, J.
name: Quinn, S.N.
name: Winn, J.N.
name: Collins, K.A.
name: Vanderspek, R.
name: Bakos, G.
name: Suc, V.
name: Siverd, R.J.
name: Berlind, P.
name: Wittenmyer, R.A.
name: Rabus, M.
name: Rodriguez, J.E.
name: Bowler, B.P.
name: Vuckovic, M.
name: Huang, C.X.
name: McCully, C.
name: McCormac, J.
name: Kielkopf, J.
name: Kossakowski, D.
name: Torres, P.
name: Fulton, B.J.
name: Jones, M.I.
name: Hobson, M.
name: Shahaf, S.
name: Plavchan, P.
name: Jenkins, J.M.
name: Irwin, J.
name: Henze, C.E.
name: Zapata, A.
name: Vanzi, L.
name: Espinoza, N.
name: Bhatti, W.
name: Mann, A.W.
name: Sarkis, P.
name: Trifonov, T.
name: Briceno, C.
name: Saesen, S.
name: Schlieder, J.E.
name: Addison, B.C.
name: Latham, D.W.
name: Hogan, A.
name: Caldwell, D.A.
name: Rojas, F.
name: Shiao, B.
name: Mengel, M.W.
name: Nielsen, L.D.
name: Brown, T.M.
name: Davis, A.B.
name: Vezie, M.
name: Ricker, G.
name: Tinney, C.G.
name: Guerrero, N.M.
name: Mazeh, T.
name: Tan, T.-G.
name: Charbonneau, D.
name: Henning, T.
name: Bieryla, A.
name: Seager, S.
name: Stassun, K.G.
name: Bayliss, D.
name: Brahm, R.
Publisher: name: IOP Publishing Ltd
Year: 2020

description: We present the discovery of two new 10 day period giant planets from the Transiting Exoplanet Survey Satellite mission, whose masses were precisely determined using a wide diversity of ground-based facilities. TOI-481 b and TOI-892 b have similar radii (0.99 0.01 and 1.07 0.02, respectively), and orbital periods (10.3311 days and 10.6266 days, respectively), but significantly different masses (1.53 0.03, respectively). Both planets orbit metal-rich stars ( = dex and = for TOI-481 and TOI-892, respectively) but at different evolutionary stages. TOI-481 is a = 1.14 0.02 = 1.66 0.02 G-type star (=K), that with an age of 6.7 Gyr, is in the turn-off point of the main sequence. TOI-892 on the other hand, is a F-type dwarf star (=K), which has a mass of = 1.28 0.03 and a radius of = 1.39 0.02. TOI-481 b and TOI-892 b join the scarcely populated region of transiting gas giants with orbital periods longer than 10 days, which is important to constrain theories of the formation and structure of hot Jupiters.
Inhibition of human immunodeficiency virus type 1 morphogenesis in T cells by alpha interferon.
Creators: name: Smith, M S
name: Pagano, J S
name: Thresher, R J
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: Some murine retroviruses exhibit altered release of virus when cells are treated with alpha interferon (IFN-alpha), resulting in the accumulation of intracellular virions in cytoplasmic vacuoles. In studies of the inhibitory effect of IFN-alpha (Wellferon) on acute human immunodeficiency virus type 1 infection of human T-cell lines, we found that in C3 cells, the 50% effective concentration was 9 U/ml and the 90% effective concentration was 310 U/ml. There was no apparent accumulation of intracellular particles detected by p24 antigen levels or by processing the cells for electron microscopy. Extracellular reverse transcriptase activity and p24 levels decreased in parallel with increasing IFN, whereas the intracellular viral proteins decreased only slightly. By electron microscopy, cells treated with higher concentrations of IFN (512 U/ml) disclosed very few particles budding into extracellular spaces; no intracellular particles could be seen, despite nearly normal levels of intracellular viral protein detected by the p24 antigen assay and correct processing detected by Western blot (immunoblot) analysis. Thus in human immunodeficiency virus-infected cells, the major block produced by IFN-alpha appeared to be late in the viral cycle at the morphogenesis stage of virion production. Chronically infected Jurkat cells treated with IFN appeared to be inhibited in growth rate, as virus production decreased proportionally with cell number.
Livro de Códigos Tese - A PERSPECTIVA TRANSFORMACIONAL DA COMPETÊNCIA EM INFORMAÇÃO COMO FATOR DE INOVAÇÃO SOCIAL
Creators: name: SANTOS, ALESSANDRA DE SOUZA
Publisher: name: Zenodo
Year: 2023

description: Documento suplementar da tese intitulada "A PERSPECTIVA TRANSFORMACIONAL DA COMPETÊNCIA EM INFORMAÇÃO COMO FATOR DE INOVAÇÃO SOCIAL". Livro de códigos gerado no software MAXQDA 2022 (versão 2022.3.0), para a pesquisa de doutorado intitulada "A PERSPECTIVA TRANSFORMACIONAL DA COMPETÊNCIA EM INFORMAÇÃO COMO FATOR DE INOVAÇÃO SOCIAL".
Vacuum energy density and pressure of a massive scalar field
Creators: name: Mera, Fernando Daniel
name: Fulling, S. A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: 81T55

description: With a view toward application of the Pauli-Villars regularization method to the Casimir energy of boundaries, we calculate the expectation values of the components of the stress tensor of a confined massive field in 1+1 space-time dimensions. Previous papers by Hays and Fulling are bridged and generalized. The Green function for the time-independent Schrodinger equation is constructed from the Green function for the whole line by the method of images; equivalently, the one-dimensional system is solved exactly in terms of closed classical paths and periodic orbits. Terms in the energy density and in the eigenvalue density attributable to the two boundaries individually and those attributable to the confinement of the field to a finite interval are distinguished so that their physical origins are clear. Then the pressure is found similarly from the cylinder kernel, the Green function associated most directly with an exponential frequency cutoff of the Fourier mode expansion. Finally, we discuss how the theory could be rendered finite by the Pauli-Villars method.
description: 18 pages; v2 and v3 have minor improvements
Differential-phase-shift QKD with practical Mach-Zehnder interferometer
Creators: name: Mizutani, Akihiro
name: Terashita, Masanori
name: Matsubayashi, Junya
name: Mori, Shogo
name: Matsukura, Ibuki
name: Tagawa, Suzuna
name: Tamaki, Kiyoshi
Publisher: name: arXiv
Year: 2024
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Differential-phase-shift (DPS) quantum key distribution stands as a promising protocol due to its simple implementation, which can be realized with a train of coherent pulses and a passive measurement unit. To implement the DPS protocol, it is crucial to establish security proofs incorporating practical imperfections in users' devices, however, existing security proofs make unrealistic assumptions on the measurement unit using a Mach-Zehnder interferometer. In this paper, we enhance the implementation security of the DPS protocol by incorporating a major imperfection in the measurement unit. Specifically, our proof enables us to use practical beam splitters with a known range of the transmittance rather than the one with exactly $50\%$, as was assumed in the existing security proofs. Our numerical simulations demonstrate that even with fluctuations of $\pm0.5\%$ in the transmittance from the ideal value, the key rate degrades only by a factor of 0.57. This result highlights the feasibility of the DPS protocol with practical measurement setups.
description: 30 pages, 8 figures
Viable phenomenologies of the normal state of cuprates
Creators: name: Khveshchenko, D. V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We revisit the problem of constructing an elusive scaling theory of the strange metal phase of the cuprates. By using the four robust experimentally established temperature dependencies as the constitutive relations we then predict the scaling behaviors of a number of other observables, all those for which the reliable data are available being in agreement with experiment. Such predictions are also contrasted against the recent proposal inspired by the holographic approach, thus allowing one to critically assess the status of the latter.
description: Latex, 4+ pages, no figures
019.pdf
Creators: name: Hamson, Zulkarnain
Publisher: name: figshare
Year: 2019
Subjects: subject: 200206 Globalisation and Culture
subject: FOS: Other humanities

description: Program pemberdayaan masyarakat yang dikemas dalam bentuk Tanggung Jawab Sosial Korporat (CSR) dengan Pengembangan Masyarakat (Comdev) untuk memberdayakan masyarakat lokal yang melakukan operasi perdamaian tanpa format kontrol yang jelas tidak menunjukkan pengaruh pengukuran dalam pembuatan dan penerapan program.
IJSDR1710008.pdf
Creators: name: Hamson, Zulkarnain
Publisher: name: figshare
Year: 2019
Subjects: subject: 169901 Gender Specific Studies
subject: FOS: Sociology
subject: 160609 Political Theory and Political Philosophy
subject: FOS: Political science

description: Voters Perception on Gender Equity in Public Elections in Makassar City, Indonesia
Inhibitory effects of acyclic nucleoside phosphonate analogs, including (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, on Epstein-Barr virus replication.
Creators: name: Pagano, J S
name: De Clercq, E
name: Lin, J C
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: (S)-9-(3-Hydroxy-2-phosphonylmethoxypropyl)adenine [(S)-HPMPA], (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)-2,6-diaminopurine [(S)-HPMPDAP], cyclic (S)-HPMPA [(S)-cHPMPA], 9-(2-phosphonylmethoxy-ethoxyethyl)-2,6-diaminopurine (PMEDAP), and (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine [(S)-HPMPC] were examined for their inhibitory effects on Epstein-Barr virus (EBV) replication.(S)-9-(3-Hydroxy-2-phosphonylmethoxypropyl)adenine [(S)-HPMPA], (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)-2,6-diaminopurine [(S)-HPMPDAP], cyclic (S)-HPMPA [(S)-cHPMPA], 9-(2-phosphonylmethoxy-ethoxyethyl)-2,6-diaminopurine (PMEDAP), and (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine [(S)-HPMPC] were examined for their inhibitory effects on Epstein-Barr virus (EBV) replication.
Procedimentos Operacionais Padrão da Casa do Idoso
Creators: name: BENDELAQUE, Dandara De Fátima Ribeiro
name: DANIN, Natasha Rayssa Gonçalves
name: NEVES, Priscila Alcone Peres
name: FREITAS, Raimunda Cristina Palheta De
name: LOUREIRO, Raphaela Santos
name: NASCIMENTO, Andreza
name: DIAS, Sandra Suely Martins
name: GARCIA, Vanessa Silva
name: ALMEIDA, Rose Mary Calderaro De
name: SILVA, Adriano Roberto Pereira Da
name: PANTOJA, Ana Paula Pureza
name: FAÇANHA, Lorena Morais
name: BASTOS, Nathália Silva De Souza
name: SILVA, Sharlene Batista Da
Publisher: name: Zenodo
Year: 2023

description: Procedimentos Operacionais Padrão da Equipe Multiprofissional da Casa do Idoso
Relaciones Intersemióticas en la Bitácora de Diseño como Estrategia Didáctica en los Procesos de Enseñanza y Aprendizaje: Aproximación Conceptual
Creators: name: Restrepo-Quevedo, Diego Aníbal
name: Pulido, Roberto Cuervo
name: Gonzalez-Tobon, Juanita
name: Hernandez-Mihajlovic, Edgar
name: Mariño, Jorge Camacho
Publisher: name: Figshare
Year: 2019
Subjects: subject: Design
subject: 139999 Education not elsewhere classified
subject: FOS: Educational sciences

description: El presente documento expone
una aproximación conceptual a las relaciones intersemióticas en los procesos de
construcción de sentido mediados por la bitácora de diseño, como facilitadora
de estrategias didácticas en los procesos de enseñanza y aprendizaje del diseño.
Las relaciones intersemióticas en la literatura se presentan como conjuntos de interacciones
entre modos y recursos semióticos, desde esta idea, la presente aproximación
conceptual permite reconocer en el espacio de formación del aprendiz de diseño,
formas por medio de las cuales el individuo hace uso material de la bitácora de
diseño para privilegiar su construcción de sentido, generando interacciones
entre otros, los modos lingüístico, visual y espacial. Lo anterior, conduce a
que existe una gestión de significado propiciada por la bitácora como agente
didáctico que se materializa en una forma modal externa al individuo, y que va
cobrando mayor relevancia con su uso continuo, propiciando una emergencia
intersemiótica.
Characteristics of Projects Funded Under the Farmers Home Administration's Water and Waste Water Disposal Program
Creators: name: Collins, Judith N.
name: Collins, Judith N.
Publisher: name: Unknown
Year: 1982
Subjects: subject: Community/Rural/Urban Development
subject: Public Economics
subject: Resource /Energy Economics and Policy
subject: Water
subject: Waste disposal
subject: Farmers Home Administration
subject: Government aid
subject: Loans
subject: Distribution
subject: Income
subject: User cost

description: The Farmers Home Administration has been a source of grants and low-cost loans for rural water and sewer facilities since 1965, and has made about 20,000 loans and 10,000 grants since then. A random sample of 327 projects funded in fiscal 1978 was studied to determine characteristics of FmHA-funded systems and communities served. Generally funds were used to build systems with fewer than 300 hookups and grants covered 40 percent of cost. FmHA tries to provide enough grant money so that debt service on the loan is 1 percent of family income. Average debt service relative to income did not significantly differ between communities; total user charges were significantly higher relative to income in poorer communities, however.
Pharmacokinetics of cefepime in patients undergoing continuous ambulatory peritoneal dialysis.
Creators: name: Knupp, C A
name: Mattern, W
name: Hak, L J
name: Dukes, G M
name: Zaccardelli, D
name: Pfeffer, M
name: Pittman, K A
name: Barbhaiya, R H
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1992

description: The pharmacokinetics of cefepime were studied in 10 male patients receiving continuous ambulatory peritoneal dialysis therapy. Five patients received a single 1,000-mg dose and the other five received a single 2,000-mg dose; all doses were given as 30-min intravenous infusions. Serial plasma, urine, and peritoneal dialysate samples were collected; and the concentrations of cefepime in these fluids were measured over 72 h by using a high-performance liquid chromatographic assay with UV detection. Pharmacokinetic parameters were calculated by noncompartmental methods. The peak concentrations in plasma and the areas under the plasma concentration-versus-time curve for the 2,000-mg dose group were twice as high as those observed for the 1,000-mg dose group. The elimination half-life of cefepime was about 18 h and was independent of the dose. The steady-state volume of distribution was about 22 liters, and values for the 1,000- and 2,000-mg doses were not significantly different. The values for total body clearance and peritoneal dialysis clearance were about 15 and 4 ml/min, respectively. No dose dependency was observed for the clearance estimates. Over the 72-h sampling period, about 26% of the dose was excreted intact into the peritoneal dialysis fluid. For 48 h postdose, mean concentrations of cefepime in dialysate at the end of each dialysis interval exceeded the reported MICs for 90% of the isolates (MIC90s) for bacteria which commonly cause peritonitis resulting from continuous peritoneal dialysis. A parenteral dose of 1,000 or 2,000 mg of cefepime every 48 h would maintain the antibiotic levels in plasma and peritoneal fluid above the MIC90s for the most susceptible bacteria for the treatment of systemic and intraperitoneal infections [corrected].
Pharmacokinetics of concomitantly administered foscarnet and zidovudine for treatment of human immunodeficiency virus infection (AIDS Clinical Trials Group protocol 053).
Creators: name: Gambertoglio, J G
name: Aweeka, F T
name: Raasch, R
name: van der Horst, C
name: Jacobson, M A
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1992

description: Foscarnet and zidovudine (ZDV) pharmacokinetic parameters were not altered in five patients receiving 14 days of concomitant therapy. Foscarnet clearance in plasma averaged (+/- standard deviation) 0.16 +/- 0.03 and 0.13 +/- 0.05 liter/h/kg of body weight in the absence and presence of ZDV. ZDV parameters were also not significantly altered, with a mean (+/- standard deviation) oral clearance of 2.7 +/- 1.0 and 2.6 +/- 0.8 liter/h/kg for the 2 study days, respectively.
TESS Hunt for Young and Maturing Exoplanets (THYME). III. A Two-planet System in the 400 Myr Ursa Major Group
Creators: name: Zhou, G.
name: Gagliano, R.
name: Bush, J.L.
name: Newton, E.R.
name: Rizzuto, A.C.
name: Massey, B.
name: Collins, K.A.
name: Johnson, M.C.
name: Schwengeler, H.M.
name: Lovis, C.
name: Tenenbaum, P.
name: Sallam, N.H.
name: Caldwell, D.A.
name: Winn, J.N.
name: Murawski, G.
name: Terentev, I.A.
name: Kraus, A.L.
name: Desidera, S.
name: Villanueva, S.
name: Glidden, A.
name: Esquerdo, G.A.
name: Rabus, M.
name: Wilson, T.G.
name: Kane, S.R.
name: Pepe, F.A.
name: Mann, A.W.
name: Dragomir, D.
name: Hill, M.L.
name: Kristiansen, M.H.
name: Vanderburg, A.
name: Barclay, T.
name: Cosentino, R.
name: Omohundro, M.
name: Rockcliffe, K.
name: Harutyunyan, A.
name: Jacobs, T.
name: Benatti, S.
name: Jenkins, J.M.
name: Doty, J.P.
name: Aitken, M.M.
name: Latham, D.W.
name: Poretti, E.
name: Vanderspek, R.
name: Seager, S.
name: Ricker, G.R.
name: Mamajek, E.E.
name: Lacourse, D.M.
name: Thao, P.C.
name: Torres, G.
name: Twicken, J.D.
name: Wood, M.L.
name: Mortier, A.
name: Quinn, S.N.
name: Berlind, P.
Publisher: name: IOP Publishing Ltd
Year: 2020

description: Exoplanets can evolve significantly between birth and maturity, as their atmospheres, orbits, and structures are shaped by their environment. Young planets (<1 Gyr) offer an opportunity to probe the critical early stages of this evolution, where planets evolve the fastest. However, most of the known young planets orbit prohibitively faint stars. We present the discovery of two planets transiting HD 63433 (TOI 1726, TIC 130181866), a young Sun-like star. Through kinematics, lithium abundance, and rotation, we confirm that HD 63433 is a member of the Ursa Major moving group (τ = 414 ± 23 Myr). Based on the TESS light curve and updated stellar parameters, we estimate that the planet radii are 2.15 ± 0.10 R ⊕ and 2.67 ± 0.12 R ⊕, the orbital periods are 7.11 and 20.55 days, and the orbital eccentricities are lower than about 0.2. Using High Accuracy Radial velocity Planet Searcher for the Northern hemisphere velocities, we measure the Rossiter-McLaughlin signal of the inner planet, demonstrating that the orbit is prograde. Since the host star is bright (V = 6.9), both planets are amenable to transmission spectroscopy, radial velocity measurements of their masses, and more precise determination of the stellar obliquity. This system is therefore poised to play an important role in our understanding of planetary system evolution in the first billion years after formation.
Policy document on the role of seed transmission on viral disease spread to Europe
Creators: name: Gowda, M.
name: Dombrovsky, A.
Publisher: name: Zenodo
Year: 2024

description: Deliverable 4.2 investigated the possibilities for the long-distance dispersal of viruses via seed. We focused our work on the two fast spreading viruses in Europe: the tomato leaf curl New Delhi virus (ToLCNDV) and tomato brown rugose fruit virus (ToBRFV). We investigated both ‘seed-borne’ and ‘seed-transmitted’ nature of both viruses.The H2020 project VIRTIGATION - Emerging viral diseases in tomatoes and cucurbits: Implementation of mitigation strategies for durable disease management - has received funding from the European Union’s Horizon 2020 research and innovation programme under Grant Agreement No. 101000570.
Influential Factors in the Loading of the Axial Bearing of the Slewing Platform Drive in Hydraulic Excavators
Creators: name: Jovanović, Vesna
name: Marinković, Dragan
name: Janošević, Dragoslav
name: Petrović, Nikola
Publisher: name: Technische Universität Berlin
Year: 2023
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::620 Ingenieurwissenschaften::620 Ingenieurwissenschaften und zugeordnete Tätigkeiten
subject: axial bearing
subject: hydraulic excavators
subject: slewing platform drive

description: The paper contains the results of the analysis of factors that influence the loading of the axial bearing of the slewing platform drive mechanism in hydraulic excavators. The following influential factors are considered: the operations of the excavator manipulation tasks, the number of drives in the slewing platform mechanism, and the configuration of the excavator kinematic chain. The importance of the influence of these factors is assessed on the basis of the comparison between certain equivalent loads of the platform drive bearing with the diagrams of allowed load capacities of available bearings. The equivalent loads of the platform drive mechanism bearing are determined using the approach of static and dynamic excavator simulation in the programs developed on the basis of the defined mathematical models of the excavator. The equivalent loads are given with regard to the duration of the manipulation task and in the form of a spectrum of equivalent loads determined in the entire operating area of the excavator. The analysis is performed for three different configurations of the kinematic chain of a tracked hydraulic excavator with the mass of around 100000 kg.