cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
(103094) George Ashmead
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The role of extracellular matrix composition in structure and function of bioengineered skeletal muscle
Creators: name: Bian, Weining
name: Hinds, Sara
name: Bursac, Nenad
name: Dennis, Robert G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: One of the obstacles to the potential clinical utility of bioengineered skeletal muscle is its limited force generation capacity. Since engineered muscle, unlike most native muscle tissue, is composed of relatively short myofibers, we hypothesized that its force production and transmission would be profoundly influenced by cell-matrix interactions. To test this hypothesis, we systematically varied the matrix protein type (collagen I/fibrin/Matrigel) and concentration in engineered, hydrogel-based neonatal rat skeletal muscle bundles and assessed the resulting tissue structure, generation of contractile force, and intracellular Ca2+ handling. After two weeks of culture, the muscle bundles consisted of highly aligned and cross-striated myofibers and exhibited standard force-length and force-frequency relationships achieving tetanus at 40 Hz. The use of 2 mg/ml fibrin (control) yielded isometric tetanus amplitude of 1.4±0.3 mN as compared to 0.9±0.4 mN measured in collagen I-based bundles. Higher fibrin and Matrigel concentrations synergistically yielded further increase in active force generation to 2.8±0.5 mN without significantly affecting passive mechanical properties, tetanus-to-twitch ratio, and twitch kinetics. Optimized matrix composition yielded significant cellular hypertrophy (protein/DNA ratio=11.4±4.1 vs. 6.5±1.9 μg/μg in control) and a prolonged Ca2+ transient half-width (Ca50=232.8±33.3 vs. 101.7±19.8 ms). The use of growth-factor-reduced Matrigel instead of standard Matrigel did not alter the obtained results suggesting enhanced cell-matrix interactions rather than growth factor supplementation as an underlying cause for the measured increase in contractile force. In summary, biomaterial-based manipulation of cell-matrix interactions represents an important target for improving contractile force generation in engineered skeletal muscle.
(103093) Katie Dods Ashmead
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Design of ultrasonically-activatable nanoparticles using low boiling point perfluorocarbons
Creators: name: Mullin, Lee B.
name: Sheeran, Paul S.
name: Luois, Samantha H.
name: Dayton, Paul A.
name: Matsunaga, Terry O.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Recently, an interest has developed in designing in biomaterials for medical ultrasonics that can provide the acoustic activity of microbubbles, but with improved stability in vivo and a smaller size distribution for extravascular interrogation. One proposed alternative is the phase-change contrast agent. Phase-change contrast agents (PCCAs) consist of perfluorocarbons (PFCs) that are initially in liquid form, but can then be vaporized with acoustic energy. Crucial parameters for PCCAs include their sensitivity to acoustic energy, their size distribution, and their stability, and this manuscript provides insight into the custom design of PCCAs for balancing these parameters. Specifically, the relationship between size, thermal stability and sensitivity to ultrasound as a function of PFC boiling point and ambient temperature is illustrated. Emulsion stability and sensitivity can be ‘tuned’ by mixing PFCs in the gaseous state prior to condensation. Novel observations illustrate that stable droplets can be generated from PFCs with extremely low boiling points, such as octafluoropropane (b.p. −36.7°C), which can be vaporized with acoustic parameters lower than previously observed. Results demonstrate the potential for low boiling point PFCs as a useful new class of compounds for activatable agents, which can be tailored to the desired application.
(103092) Sarah Jessie Ashmead
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(103091) Mary Elizabeth Ashmead
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The effect of nitric oxide surface flux on the foreign body response to subcutaneous implants
Creators: name: Rose, Michael B.
name: Slomberg, Danielle L.
name: Brown, Nga L.
name: Klitzman, Bruce
name: Sun, Bin
name: Riccio, Daniel A.
name: Schoenfisch, Mark H.
name: Koh, Ahyeon
name: Nichols, Scott P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Although the release of nitric oxide (NO) from biomaterials has been shown to reduce the foreign body response (FBR), the optimal NO release kinetics and doses remain unknown. Herein, polyurethane-coated wire substrates with varying NO release properties were implanted into porcine subcutaneous tissue for 3, 7, 21 and 42 d. Histological analysis revealed that materials with short NO release durations (i.e., 24 h) were insufficient to reduce the collagen capsule thickness at 3 and 6 weeks, whereas implants with longer release durations (i.e., 3 and 14 d) and greater NO payloads significantly reduced the collagen encapsulation at both 3 and 6 weeks. The acute inflammatory response was mitigated most notably by systems with the longest duration and greatest dose of NO release, supporting the notion that these properties are most critical in circumventing the FBR for subcutaneous biomedical applications (e.g., glucose sensors).
(103090) Brackeney-Louisa Sommerfield
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The targeted intracellular delivery of cytochrome C protein to tumors using lipid-apolipoprotein nanoparticles
Creators: name: Foote, Michael B.
name: Huang, Leaf
name: Kim, Sang Kyoon
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Intracellular-acting therapeutic proteins offer a promising clinical alternative to extracellular-acting agents, but are limited in efficacy by their low permeability into the cell cytoplasm. We have developed a nanoparticle (NP) composed of lipid (DOTAP/DOPE) and apolipoprotein (APO A-I) to mediate the targeted delivery of intracellular-acting protein drugs to non-small cell lung tumors. NPs were produced with either GFP, a fluorescent model protein, or cytochrome C (cytC), an inducer of apoptosis in cancer cells. GFP and cytC were separately conjugated with a membrane permeable sequence (MPS) peptide and were admixed with DOPE/DOTAP nanoparticle formulations (NPs) to enable successful protein loading. Protein-loaded NPs were modified with DSPE-PEG-Anisamide to enable specific NP targeting to the tumor site in a xenograft model. The resulting particle was 20–30 nm in size and exhibited a 64–75% loading efficiency. H460 cells treated with the PEGylated MPS-cytC-NPs exhibited massive apoptosis. When MPS-GFP-NPs or MPS-cytC-NPs were intravenously administered in H460 tumor bearing mice, a specific tumor targeting effect with low NP accumulation in the liver was observed. In addition, MPS-cytC-NP treatment provoked a tumor growth retardation effect in H460 xenograft mice. We conclude that our NP enables targeted, efficacious therapeutic protein delivery for the treatment of lung cancer.
Particle acceleration and their escape into the heliosphere in solar flares with open magnetic field
Creators: name: Gordovskyy, Mykola
name: Browning, Philippa K.
name: Kusano, Kanya
name: Inoue, Satoshi
name: Vekstein, Gregory E.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: Energetic particle populations in the solar corona and in the heliosphere appear to have different characteristics even when produced in the same solar flare. It is not clear what causes this difference: properties of the acceleration region, the large-scale magnetic field configuration in the flare, or particle transport effects, such as scattering. In this study we use a combination of magnetohydrodynamic and test-particle approaches to investigate magnetic reconnection, particle acceleration and transport in two solar flares: an M-class flare on June 19th, 2013, and an X-class flare on September 6th, 2011. We show that in both events , the same regions are responsible for the acceleration of particles remaining in the coronal and being ejected towards the heliosphere. However, the magnetic field structure around the acceleration region acts as a filter, resulting in different characteristics (such as energy spectra) acquired by these two populations. We argue that this effect is an intrinsic property of particle acceleration in the current layers created by the interchange reconnection and, therefore, may be ubiquitous, particularly, in non-eruptive solar flares with substantial particle emission into the heliosphere.
description: This is the Accepted Manuscript version of an article accepted for publication in Astrophysical Journal. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it
SphereMap: Dynamic Multi-Layer Graph Structure for Rapid Safety-Aware UAV Planning
Creators: name: Musil, Tomáš
name: Petrlík, Matěj
name: Saska, Martin
Publisher: name: arXiv
Year: 2023
Subjects: subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: A flexible topological representation consisting of a two-layer graph structure built on-board an Unmanned Aerial Vehicle (UAV) by continuously filling the free space of an occupancy map with intersecting spheres is proposed in this \paper{}. Most state-of-the-art planning methods find the shortest paths while keeping the UAV at a pre-defined distance from obstacles. Planning over the proposed structure reaches this pre-defined distance only when necessary, maintaining a safer distance otherwise, while also being orders of magnitude faster than other state-of-the-art methods. Furthermore, we demonstrate how this graph representation can be converted into a lightweight shareable topological-volumetric map of the environment, which enables decentralized multi-robot cooperation. The proposed approach was successfully validated in several kilometers of real subterranean environments, such as caves, devastated industrial buildings, and in the harsh and complex setting of the final event of the DARPA SubT Challenge, which aims to mimic the conditions of real search and rescue missions as closely as possible, and where our approach achieved the \nth{2} place in the virtual track.
(103089) Thomas Hetherington
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Albumin-based nanoconjugates for targeted delivery of therapeutic oligonucleotides
Creators: name: Wu, Lin
name: Carver, Kyle
name: Ming, Xin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Nanoparticle-based delivery has become an important strategy to advance siRNA and antisense oligonucleotides into clinical reality. However, limited biodistribution of nanoparticles and the toxicity of some nanocarriers restrict the wider application of this strategy. To address these issues we aimed to construct oligonucleotide delivery systems which are non-cytotoxic and smaller than typical nanoparticles. Thus, a morpholino oligonucleotide was conjugated to a tumor-targeting RGD peptide, and then, multiple RGD-oligo conjugates were linked to a single molecule of human serum albumin via a reductively responsive linkage. The resultant nanoconjugates showed uniform and monodispersed size distribution with a diameter of 13 nm. A single nanoconjugate molecule contains 15 oligonucleotides as well as 15 targeting ligands on the surface of albumin. The nanoparticle demonstrated 61-fold enhancement in receptor-specific cellular delivery of oligonucleotides in integrin-expressing tumor cells compared to the non-targeted control nanoconjugates and were able to robustly enhance functional activity of the oligonucleotide at low nanomolar concentrations without causing cytotoxicity. Due to their small size, the targeted nanoconjugates could penetrate deeply and distribute throughout 3-D tumor spheroids, whereas the conventional nanoparticles with sizes over 300 nm could only deliver to the cells on the surface of the tumor spheroids. As a result of their greater cellular delivery, smaller size, and lack of cytotoxicity compared to conventional nanoparticles, the multivalent nanoconjugates may provide an effective tool for targeting oligonucleotides to tumors and other diseased tissues.
(103087) Martha Louisa Hetherington
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Operator ideals in Tate objects
Creators: name: Braunling, Oliver
name: Groechenig, Michael
name: Wolfson, Jesse
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Geometry (math.AG)
subject: Rings and Algebras (math.RA)
subject: FOS: Mathematics
subject: 18E10, 22B99

description: Tate's central extension originates from 1968 and has since found many applications to curves. In the 80s Beilinson found an n-dimensional generalization: cubically decomposed algebras, based on ideals of bounded and discrete operators in ind-pro limits of vector spaces. Kato and Beilinson independently defined '(n-)Tate categories' whose objects are formal iterated ind-pro limits in general exact categories. We show that the endomorphism algebras of such objects often carry a cubically decomposed structure, and thus a (higher) Tate central extension. Even better, under very strong assumptions on the base category, the n-Tate category turns out to be just a category of projective modules over this type of algebra.
Combinational delivery of c-myc siRNA and nucleoside analogs in a single, synthetic nanocarrier for targeted cancer therapy
Creators: name: Zhang, Yuan
name: Mumper, Russell J.
name: Huang, Leaf
name: Peng, Lei
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The treatment of aggressive non-small-cell lung cancer (NSCLC) depends on the creation of new therapeutic regimens in clinical settings. In this study, we developed a Lipid/Calcium/Phosphate (LCP) nanoparticle that combines chemotherapy with gene therapy. By encapsulating a chemodrug, gemcitabine monophosphate (GMP), and siRNA specific to the undruggable c-Myc oncogene (c-Myc siRNA) into a single nanosized vesicle and systemically administering them to nude mice, we achieved potent anti-tumor activity in both subcutaneous and orthotopic models of NSCLC. The improvements in therapeutic response over either c-Myc siRNA or GMP therapy alone, were demonstrated by the ability to effectively induce the apoptosis of tumor cells and the significant reduction of proliferation of tumor cells. The combination therapy led to dramatic inhibition of tumor growth, with little in vivo toxicity. Additionally, the current studies demonstrated the possibility of incorporating both nucleic acid molecules and phosphorylated small molecule drugs into the inner core of a single nanoparticle formulation. Co-encapsulation of an oncogene-modulating siRNA and a chemotherapeutic agent will allow simultaneous interruption of diverse anti-cancer pathways, leading to increased therapeutic efficacy and reduced toxicities.
Virtual-reality based examination of audiovisual prosody in cochlear implant recipients
Creators: name: Abdellatif, Khaled
name: Winter, Isa Samira
name: Wächtler, Moritz
name: Sandmann, Pascale
name: Meister, Hartmut
Publisher: name: RWTH Aachen University
Year: 2023

description: Proceedings of the 1st AUDICTIVE Conference. - June 19-22, 2023, RWTH Aachen University, Aachen, Germany / editors: Jamilla Balint, Janina Fels 1. AUDICTIVE Conference, Aachen, Germany, 19 Jun 2023 - 22 Jun 2023; Aachen : RWTH Aachen University, Institute for Hearing Technology and Acoustics 42-42 (2023).
description: Published by RWTH Aachen University, Institute for Hearing Technology and Acoustics, Aachen
The Large Deficit of HMXB Emission from Luminous Infrared Galaxies: the Case of the Circumnuclear Starburst Ring in NGC 7552
Creators: name: West, Lacey
name: Garofali, Kristen
name: Lehmer, Bret D.
name: Prestwich, Andrea
name: Eufrasio, Rafael
name: Luangtip, Wasutep
name: Roberts, Timothy P.
name: Zezas, Andreas
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Luminous infrared galaxies (LIRGs), the most extreme star-forming galaxies in the nearby (D$<$30 Mpc) Universe, show a notable X-ray emission deficiency (up to a factor of $\sim$10) compared with predictions from scaling relations of galaxy-wide high mass X-ray binary (HMXB) luminosity with star-formation rate. In the nearby ($\approx$20 Mpc) LIRG NGC 7552, the majority of the IR emission originates in a circumnuclear starburst ring, which has been resolved into several discrete knots of star formation. We present results from recent Chandra observations of NGC 7552, which reveal significant deficits in the 2-7 keV X-ray luminosities from two of the most powerful star-forming knots. We hypothesize that the expected luminous HMXB populations in these knots are either (1) obscured by very large column densities or (2) suppressed due to the knots having relatively high metallicity and/or very young ages ($\lesssim$ 5 Myr). We distinguish between these possibilities using data from recent NuSTAR observations, whose sensitivity above 10 keV is capable of uncovering heavily obscured HMXB populations, since emission at these energies is more immune to absorption effects. We find no evidence of a heavily obscured HMXB population in the central region of NGC 7552, suggesting suppressed HMXB formation. We further show that metallicity-dependent scaling relations cannot fully account for the observed deficit from the most powerful star-forming knots or the central region as a whole. Thus, we suggest that recent bursts in local star formation activity likely drive the high $L_{\rm{IR}}$ within these regions on timescales $\lesssim$ 5 Myr, shorter than the timescale required for the formation of HMXBs.
description: Accepted for publication in ApJ (17 pages, 3 tables, 8 figures)
Hyperbolic groups with boundary an n-dimensional Sierpinski space
Creators: name: Lafont, Jean-François
name: Tshishiku, Bena
Publisher: name: arXiv
Year: 2015
Subjects: subject: Geometric Topology (math.GT)
subject: Group Theory (math.GR)
subject: FOS: Mathematics

description: For n>6, we show that if G is a torsion-free hyperbolic group whose visual boundary is an (n-2)-dimensional Sierpinski space, then G=π_1(W) for some aspherical n-manifold W with nonempty boundary. Concerning the converse, we construct, for each n>3, examples of aspherical manifolds with boundary, whose fundamental group G is hyperbolic, but with visual boundary not homeomorphic to an (n-2)-dimensional Sierpinski space.
description: 11 pages
(103086) Alfred Francis Ashmead
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Jointly-Optimized Searching and Tracking with Random Finite Sets
Creators: name: Papaioannou, Savvas
name: Kolios, Panayiotis
name: Theocharides, Theocharis
name: Panayiotou, Christos G.
name: Polycarpou, Marios M.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Systems and Control (eess.SY)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In this paper, we investigate the problem of joint searching and tracking of multiple mobile targets by a group of mobile agents. The targets appear and disappear at random times inside a surveillance region and their positions are random and unknown. The agents have limited sensing range and receive noisy measurements from the targets. A decision and control problem arises, where the mode of operation (i.e., search or track) as well as the mobility control action for each agent, at each time instance, must be determined so that the collective goal of searching and tracking is achieved. We build our approach upon the theory of random finite sets (RFS) and we use Bayesian multi-object stochastic filtering to simultaneously estimate the time-varying number of targets and their states from a sequence of noisy measurements. We formulate the above problem as a non-linear binary program (NLBP) and show that it can be approximated by a genetic algorithm. Finally, to study the effectiveness and performance of the proposed approach we have conducted extensive simulation experiments.
description: arXiv admin note: text overlap with arXiv:2302.00518
Effects of partial ionization on magnetic flux emergence in the Sun
Creators: name: Chouliaras, Georgios
name: Syntelis, P.
name: Archontis, V.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We have performed 3-D numerical simulations to investigate the effect of partial ionization on the process of magnetic flux emergence. In our study, we have modified the single-fluid MHD equations to include the presence of neutrals and have performed two basic experiments: one that assumes a fully ionized plasma (FI case) and one that assumes a partially ionized plasma (PI case). We find that the PI case brings less dense plasma to and above the solar surface. Furthermore, we find that partial ionization alters the emerging magnetic field structure, leading to a different shape of the polarities in the emerged bipolar regions compared to the FI case. The amount of emerging flux into the solar atmosphere is larger in the PI case, which has the same initial plasma beta as the FI case, but a larger initial magnetic field strength. The expansion of the field above the photosphere occurs relatively earlier in the PI case, and we confirm that the inclusion of partial ionization reduces cooling due to adiabatic expansion. However, it does not appear to work as a heating mechanism for the atmospheric plasma. The performance of these experiments in three dimensions shows that PI does not prevent the formation of unstable magnetic structures, which erupt into the outer solar atmosphere.
Nanoparticle drug loading as a design parameter to improve docetaxel pharmacokinetics and efficacy
Creators: name: Wang, Andrew Z.
name: Luft, James C.
name: Schorzman, Allison N.
name: Bowerman, Charles J.
name: Zamboni, William C.
name: Chu, Kevin S.
name: Madden, Andrew J.
name: DeSimone, Joseph M.
name: Finniss, Mathew C.
name: Peng, Lei
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Nanoparticle (NP) drug loading is one of the key defining characteristics of a NP formulation. However, the effect of NP drug loading on therapeutic efficacy and pharmacokinetics has not been thoroughly evaluated. Herein, we characterized the efficacy, toxicity and pharmacokinetic properties of NP docetaxel formulations that have differential drug loading but are otherwise identical. Particle Replication in Non-wetting Templates (PRINT®), a soft-lithography fabrication technique, was used to formulate NPs with identical size, shape and surface chemistry, but with variable docetaxel loading. The lower weight loading (9%-NP) of docetaxel was found to have a superior pharmacokinetic profile and enhanced efficacy in a murine cancer model when compared to that of a higher docetaxel loading (20%-NP). The 9%-NP docetaxel increased plasma and tumor docetaxel exposure and reduced liver, spleen and lung exposure when compared to that of 20%-NP docetaxel.
Competency Analysis of Education Administrators in the Office of Secondary Educational Service Area in the Disruptive Era
Creators: name: Unchalee Maithong
Publisher: name: DR.KEN Institute of Academic Development and Promotion.
Year: 2023
Subjects: Educational Administrators Competency
, Disruption
Education Management
Secondary Education Service Area Office

description: Interdisciplinary Academic and Research Journal, 3, 5, 425-446
(103082) Eleanor Frances Warre
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Problem-based Learning Management with Graphic Organizer to improve Collaborative Problem-Solving Competency and Academic Achievement for Grand 11 Students on Photosynthesis
Creators: name: Nissara Bunloisong
Publisher: name: DR.KEN Institute of Academic Development and Promotion.
Year: 2023
Subjects: Problem-based Learning Management Graphic organizer
Problem-solving Competency
Academic achievement

description: Interdisciplinary Academic and Research Journal, 3, 5, 447-464
(103081) George Fitzclarence Slade
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(103080) Edmond John Warre Slade
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Systemic delivery of gemcitabine triphosphate via LCP nanoparticles for NSCLC and pancreatic cancer therapy
Creators: name: Huang, Leaf
name: Kim, William Y.
name: Zhang, Yuan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Nucleoside analogues are a significant class of anticancer agent. As prodrugs, they terminate the DNA synthesis upon transforming to their active triphosphate metabolites. We have encapsulated a biologically activate nucleotide analogue (i.e. gemcitabine triphosphate (GTP)), instead of the nucleoside (i.e. gemcitabine) derivative, into a novel Lipid/Calcium/Phosphate nanoparticle (LCP) platform. The therapeutic efficacy of LCP-formulated GTP was evaluated in a panel of human non-small-cell lung cancer (NSCLC) and human pancreatic cancer models after systemic administrations. GTP-loaded LCPs induced cell death and arrested the cell cycle in the S phase. In vivo efficacy studies showed that intravenously injected GTP-loaded LCPs triggered effective apoptosis of tumor cells, significant reduction of tumor cell proliferation and cell cycle progression, leading to dramatic inhibition of tumor growth, with little in vivo toxicity. Broadly speaking, the current study offers preclinical proof-of-principle that many active nucleotide or phosphorylated nucleoside analogues could be encapsulated in the LCP nanoplatform and delivered systemically for a wide variety of therapeutic applications.
(103076) Isabella Louisa Daniell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Alveolar epithelial differentiation of human induced pluripotent stem cells in a rotating bioreactor
Creators: name: Raredon, Micha Sam B.
name: Sivarapatna, Amogh
name: Ghaedi, Mahboobe
name: Mendez, Julio J.
name: Bove, Peter F.
name: Niklason, Laura E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Traditional stem cell differentiation protocols make use of a variety of cytokines including growth factors (GFs) and inhibitors in an effort to provide appropriate signals for tissue specific differentiation. In this study, iPSC-derived type II pneumocytes (iPSC-ATII) as well as native isolated human type II pneumocytes (hATII) were differentiated toward a type I phenotype using a unique air–liquid interface (ALI) system that relies on a rotating apparatus that mimics in vivo respiratory conditions. A relatively homogenous population of alveolar type II-like cells from iPSC was first generated (iPSC-ATII cells), which had phenotypic properties similar to mature human alveolar type II cells. iPSC-ATII cells were then cultured in a specially designed rotating culture apparatus. The effectiveness of the ALI bioreactor was compared with the effectiveness of small molecule-based differentiation of type II pneumocytes toward type 1 pneumocytes. The dynamics of differentiation were examined by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR), flow cytometry and immunocytochemistry. iPSC-ATII and hATII cells cultured in the ALI bioreactor had higher levels of type I markers, including aquaporin-5(AQ5), caveolin-1, and T1α, at both the RNA and protein levels as compared with the flask-grown iPSC-ATII and hATII that had been treated with small molecules to induce differentiation. In summary, this study demonstrates that a rotating bioreactor culture system that provides an air–liquid interface is a potent inducer of type I epithelial differentiation for both iPS-ATII cells and hATII cells, and provides a method for large-scale production of alveolar epithelium for tissue engineering and drug discovery.
IT and Lacan / IT i Lacan
Creators: name: Fuks, Adam Mateusz Jan
Publisher: name: Zenodo
Year: 2022
Subjects: lacan, psychoanalysis, haskell, scheme, lisp, c++, category theory, computer security

description: EN Towards formalization of Lacanian Psychoanalysis. The paper applies computer science and mathematical terms to psychoanalytical concepts to aid formalization of Lacanian Psychoanalysis. This paper is a work in progress. PL Ku formalizacji Psychoanalizy Lacanowskiej. W artykule terminy informatyczne i matematyczne stosowane są do pojęć psychoanalitycznych celem formalizacji Psychoanalizy Lacanowskiej. Prace nad artykułem są w toku. https://github.com/aammff/lacan
description: {"references": ["https://github.com/aammff/lacan"]}
The Effect of Learning Management Based on Constructivist Theory Using Hand-on Activities of Grade 6 Students’ Geometrical Concepts on Triangle
Creators: name: Natnicha Bunyodom
Publisher: name: DR.KEN Institute of Academic Development and Promotion.
Year: 2023
Subjects: Constructivist
Hand – on activities
Geometrical concepts

description: Interdisciplinary Academic and Research Journal, 3, 5, 481-496
(103074) Herbert de Rougemont
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Comment on "Searching for Topological Defect Dark Matter via Nongravitational Signatures"
Creators: name: Avelino, P. P.
name: Sousa, L.
name: Lobo, Francisco S. N.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In the letter by Stadnik and Flambaum [Phys. Rev. Lett. 113, 151301 (2014)] it is claimed that topological defects passing through pulsars could be responsible for the observed pulsar glitches. Here, we show that, independently of the detailed network dynamics and defect dimensionality, such proposal is faced with serious difficulties.
description: 2 pages
Analytical Thinking and Academic Achievement in Biology on Chromosomes and Genetic Material of Mathayomsuksa 4 students receiving Cooperative Learning Management in STAD format together with Concept Map
Creators: name: Panthip Kongkham
Publisher: name: DR.KEN Institute of Academic Development and Promotion.
Year: 2023
Subjects: STAD
Concept map
Analytical Thinking

description: Interdisciplinary Academic and Research Journal, 3, 5, 97-510
Influence of polyethylene glycol density and surface lipid on pharmacokinetics and biodistribution of lipid-calcium-phosphate nanoparticles
Creators: name: Huang, Leaf
name: Hu, Yunxia
name: Liu, Yang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The pharmacokinetics (PK) and biodistribution of nanoparticles (NPs) are controlled by a complex array of interrelated, physicochemical and biological factors of NPs. The lipid-bilayer core structure of the Lipid-Calcium-Phosphate (LCP) NPs allows us to examine the effects of the density of polyethylene glycol (PEG) and the incorporation of various lipids onto the surface on their fate in vivo. Fluorescence quantification estimated that up to 20% (molar percent of outer leaflet lipids) could be grafted on the surface of LCP NPs. Contrary to the common belief that high level of PEGylation could prevent the uptake of NPs by the reticuloendothelial system (RES) organs such as liver and spleen, a significant amount of the injected dose was observed in the liver. Confocal microscopy revealed that LCP NPs were largely localized in hepatocytes not Kupffer cells. It was further demonstrated that the delivery to hepatocytes was dependent on both the concentration of PEG and the surface lipids. LCP NPs could be directed from hepatocytes to Kupffer cells by decreasing PEG concentration on the particle surface. In addition, LCP NPs with 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) exhibited higher accumulation in the hepatocytes than LCP NPs with dioleoylphosphatidylcholine (DOPC). Analysis of the proteins bound to NPs suggested that apolipoprotein E (apoE) might serve as an endogenous targeting ligand for LCP-DOTAP NPs, but not LCP-DOPC NPs. The significant uptake of NPs by the hepatocytes is of great interest to formulation design for oncologic and hepatic drug deliveries.
Lipid–calcium phosphate nanoparticles for delivery to the lymphatic system and SPECT/CT imaging of lymph node metastases
Creators: name: Guley, Kevin
name: Tseng, Yu Cheng
name: Xu, Zhenghong
name: Huang, Leaf
name: Yuan, Hong
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: A lipid/calcium/phosphate (LCP) nanoparticle (NP) formulation (particle diameter ~25 nm) with superior siRNA delivery efficiency was developed and reported previously. Here, we describe the successful formulation of 111In into LCP for SPECT/CT imaging. Imaging and biodistribution studies showed that, polyethylene glycol grafted 111In-LCP preferentially accumulated in the lymph nodes at ~70% ID/g in both C57BL/6 and nude mice when the improved surface coating method was used. Both the liver and spleen accumulated only ~25% ID/g. Larger LCP (diameter ~67 nm) was less lymphotropic. These results indicate that 25 nm LCP was able to penetrate into tissues, enter the lymphatic system, and accumulate in the lymph nodes via lymphatic drainage due to 1) small size, 2) a well-PEGylated lipid surface, and 3) a slightly negative surface charge. The capability of intravenously injected 111In-LCP to visualize an enlarged, tumor-loaded sentinel lymph node was demonstrated using a 4T1 breast cancer lymph node metastasis model. Systemic gene delivery to the lymph nodes after IV injection was demonstrated by the expression of red fluorescent protein cDNA. The potential of using LCP for lymphatic drug delivery is discussed.
Deployment of Reliable Visual Inertial Odometry Approaches for Unmanned Aerial Vehicles in Real-world Environment
Creators: name: Bednář, Jan
name: Petrlík, Matěj
name: Vivaldini, Kelen Cristiane Teixeira
name: Saska, Martin
Publisher: name: arXiv
Year: 2023
Subjects: subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: Integration of Visual Inertial Odometry (VIO) methods into a modular control system designed for deployment of Unmanned Aerial Vehicles (UAVs) and teams of cooperating UAVs in real-world conditions are presented in this paper. Reliability analysis and fair performance comparison of several methods integrated into a control pipeline for achieving full autonomy in real conditions is provided. Although most VIO algorithms achieve excellent localization precision and negligible drift on artificially created datasets, the aspects of reliability in non-ideal situations, robustness to degraded sensor data, and the effects of external disturbances and feedback control coupling are not well studied. These imperfections, which are inherently present in cases of real-world deployment of UAVs, negatively affect the ability of the most used VIO approaches to output a sensible pose estimation. We identify the conditions that are critical for a reliable flight under VIO localization and propose workarounds and compensations for situations in which such conditions cannot be achieved. The performance of the UAV system with integrated VIO methods is quantitatively analyzed w.r.t. RTK ground truth and the ability to provide reliable pose estimation for the feedback control is demonstrated onboard a UAV that is tracking dynamic trajectories under challenging illumination.
Merged-beams Reaction Studies of O + H_3^+
Creators: name: de Ruette, N.
name: Miller, K. A.
name: O'Connor, A. P.
name: Urbain, X.
name: Buzard, C. F.
name: Vissapragada, S.
name: Savin, D. W.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We have measured the reaction of O + H3+ forming OH+ and H2O+. This is one of the key gas-phase astrochemical processes initiating the formation of water molecules in dense molecular clouds. For this work, we have used a novel merged fast-beams apparatus which overlaps a beam of H3+ onto a beam of ground-term neutral O. Here, we present cross section data for forming OH+ and H2O+ at relative energies from \approx 3.5 meV to \approx 15.5 and 0.13 eV, respectively. Measurements were performed for statistically populated O(3PJ) in the ground term reacting with hot H3+ (with an internal temperature of \approx 2500-3000 K). From these data, we have derived rate coefficients for translational temperatures from \approx 25 K to \approx 10^5 and 10^3 K, respectively. Using state-of-the-art theoretical methods as a guide, we have converted these results to a thermal rate coefficient for forming either OH+ or H2O+, thereby accounting for the temperature dependence of the O fine-structure levels. Our results are in good agreement with two independent flowing afterglow measurements at a temperature of \approx 300 K, and with a corresponding level of H3+ internal excitation. This good agreement strongly suggests that the internal excitation of the H3+ does not play a significant role in this reaction. The Langevin rate coefficient is in reasonable agreement with the experimental results at 10 K but a factor of \approx 2 larger at 300 K. The two published classical trajectory studies using quantum mechanical potential energy surfaces lie a factor of \approx 1.5 above our experimental results over this 10-300 K range.
description: 43 pages, 11 figures. Submitted to the Astrophysical Journal
IT and Lacan / IT i Lacan
Creators: name: Fuks, Adam Mateusz Jan
Publisher: name: Zenodo
Year: 2022
Subjects: lacan, psychoanalysis, haskell, scheme, lisp, c++, category theory

description: EN Towards formalization of Lacanian Psychoanalysis. The paper applies computer science and mathematical terms to psychoanalytical concepts to aid formalization of Lacanian Psychoanalysis. This paper is a work in progress. PL Ku formalizacji Psychoanalizy Lacanowskiej. W artykule terminy informatyczne i matematyczne stosowane są do pojęć psychoanalitycznych celem formalizacji Psychoanalizy Lacanowskiej. Prace nad artykułem są w toku. https://github.com/aammff/lacan
description: {"references": ["https://github.com/aammff/lacan"]}