cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Hilbert space inner products for PT-symmetric Su-Schrieffer-Heeger models
Creators: name: Ruzicka, Frantisek
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: A Su-Schrieffer-Heeger model with added PT-symmetric boundary term is studied in the framework of pseudo-hermitian quantum mechanics. For two special cases, a complete set of pseudometrics is constructed in closed form. When complemented with a condition of positivity, the pseudometrics determine all the physical inner products of the considered model.
description: 10 pages, 5 figures
Slow but sure: the potential of slow-release nitrogen fertilizers to increase crop productivity and farm profit in Nepal
Creators: name: Pandit, Naba Raj
name: Gaihre, Yam Kanta
name: Choudhary, Dyutiman
name: Subedi, Roshan
name: Thapa, Surya Bahadur
name: Maharjan, Shashish
name: Khadka, Dinesh
name: Vista, Shree Prasad
name: Rusinamhodzi, Leonard
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Cell Biology
subject: Neuroscience
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: Reduction of nitrogen (N) input in cropping systems is critical to reduce environmental pollution and achieve sustainable development goals. Multi-location field trials for maize (n = 120) and rice (n = 84) were conducted across nine districts in Nepal during 2018 and 2019 to assess the potential of polymer coated urea (PCU) and urea briquette (UB) to increase agronomic N use efficiency (AEN), crop productivity and farm profits over conventional urea (CU). Nitrogen rates applied in PCU and UB treatments were 22% to 50% lower than CU (120 and 100 kg N ha−1 for maize and rice respectively). In maize, both PCU (8.4 t ha−1) and UB (8.5 t ha−1) applied at 50% and 25% lower N rates respectively produced similar grain yields compared with CU (7.9 t ha−1). Similar results were observed in rice where PCU and UB applied at 22% less N led to a productivity of 5.4 and 5.5 t ha−1 respectively over CU (5.1 t ha−1). Moreover, both PCU and UB increased maize and rice yields significantly compared with current farmer’s practices (FP). In both maize and rice, PCU and UB significantly increased partial factor productivity of N (PFPN) and agronomic NUE (AEN) compared with CU. Furthermore, PCU and UB increased farmer’s net income by US$88 and US$148 in maize and by US$10 and US$87 in rice respectively. These results suggest that PCU and UB could save N input by 22-50% while maintaining similar or even higher yield and higher benefit to farmers compared with CU.
Origin of Structure in the Universe: Quantum Cosmology Reconsidered
Creators: name: Anderson, Edward
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Based on a more careful canonical analysis, we motivate a reduced quantization - in the sense of superspace quantization - of slightly inhomogeneous cosmology in place of the Dirac quantization in the existing literature, and provide it in the vacuum case. This is attained through consideration of configuration space geometries at various levels of reduction. Some of these have the good fortunate of being flat. Geometrically natural coordinates for these are interpreted in terms of the original redundant formulation's well-known mode expansion coefficients.
description: 12 pages, including 1 figure. This version has 7 new pages of details, comments and references
Decay of solutions to the Maxwell equation on the Schwarzschild background
Creators: name: Andersson, Lars
name: Bäckdahl, Thomas
name: Blue, Pieter
Publisher: name: arXiv
Year: 2015
Subjects: subject: Analysis of PDEs (math.AP)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 35Q61, 83C60, 83C57

description: A new Morawetz or integrated local energy decay estimate for Maxwell test fields on the exterior of a Schwarzschild black hole spacetime is proved. The proof makes use of a new superenergy tensor $H_{ab}$ defined in terms of the Maxwell field and its first derivatives. The superenergy tensor, although not conserved, yields a conserved higher order energy current $H_{ab} (\partial_t)^b$. The tensor $H_{ab}$ vanishes for the static Coulomb field, and the Morawetz estimate proved here therefore yields integrated decay for the Maxwell field to the Coulomb solution on the Schwarzschild exterior.
description: 15 pages, updated references
Notes on Schubert, Grothendieck and Key Polynomials
Creators: name: Kirillov, Anatol N.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05E05, 05E10, 05A19

description: We introduce common generalization of (double) Schubert, Grothendieck, Demazure, dual and stable Grothendieck polynomials, and Di Francesco-Zinn-Justin polynomials. Our approach is based on the study of algebraic and combinatorial properties of the reduced rectangular plactic algebra and associated Cauchy kernels.
The nature of $Z_b$ states from a combined analysis of $Υ(5S)\rightarrow h_b(mP) π^+ π^-$ and $Υ(5S)\rightarrow B^{(\ast)}\bar B^{(\ast)}π$
Creators: name: Huo, Wen-Sheng
name: Chen, Guo-Ying
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: With a combined analysis of data on $Υ(5S)\rightarrow h_b(1P,2P)π^+π^-$ and $Υ(5S)\rightarrow B^{(\ast)}\bar B^{(\ast)}π$ in an effective field theory approach, we determine resonance parameters of $Z_b$ states in two scenarios. In one scenario we assume that $Z_b$ states are pure molecular states, while in the other one we assume that $Z_b$ states contain compact components. We find that the present data favor that there should be some compact components inside $Z_b^{(\prime)}$ associated with the molecular components. By fitting the invariant mass spectra of $Υ(5S)\rightarrow h_b(1P,2P)π^+π^-$ and $Υ(5S)\rightarrow B^{(\ast)}\bar B^{\ast}π$, we determine that the probability of finding the compact components in $Z_b$ states may be as large as about $40\%$.
description: Discussions added, version published in EPJC
Persistence, Localization, and External Control of Transgene Expression After Single Injection of Adeno-Associated Virus into Injured Joints
Creators: name: Lee, Hannah H.
name: Qiao, Chunping
name: Friel, Nicole A.
name: Payne, Karin A.
name: O'Malley, Michael J.
name: Chu, Constance R.
name: Xiao, Xiao
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: A single intra-articular injection of adeno-associated virus (AAV) results in stable and controllable transgene expression in normal rat knees. Because undamaged joints are unlikely to require treatment, the study of AAV delivery in joint injury models is crucial to potential therapeutic applications. This study tests the hypotheses that persistent and controllable AAV-transgene expression are (1) highly localized to the cartilage when AAV is injected postinjury and (2) localized to the intra-articular soft tissues when AAV is injected preinjury. Two AAV injection time points, postinjury and preinjury, were investigated in osteochondral defect and anterior cruciate ligament transection models of joint injury. Rats injected with AAV tetracycline response element (TRE)–luciferase received oral doxycycline for 7 days. Luciferase expression was evaluated longitudinally for 6 months. Transgene expression was persistent and controllable with oral doxycycline for 6 months in all groups. However, the location of transgene expression was different: postinjury AAV-injected knees had luciferase expression highly localized to the cartilage, while preinjury AAV-injected knees had more widespread signal from intra-articular soft tissues. The differential transgene localization between preinjury and postinjury injection can be used to optimize treatment strategies. Highly localized postinjury injection appears advantageous for treatments targeting repair cells. The more generalized and controllable reservoir of transgene expression following AAV injection before anterior cruciate ligament transection (ACLT) suggests an intriguing concept for prophylactic delivery of joint protective factors to individuals at high risk for early osteoarthritis (OA). Successful external control of intra-articular transgene expression provides an added margin of safety for these potential clinical applications.
On a Lagrangian reduction and a deformation of completely integrable systems
Creators: name: Arnaudon, Alexis
Publisher: name: arXiv
Year: 2015
Subjects: subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We develop a theory of Lagrangian reduction on loop groups for completely integrable systems after having exchanged the role of the space and time variables in the multi-time interpretation of integrable hierarchies. We then insert the Sobolev norm $H^1$ in the Lagrangian and derive a deformation of the corresponding hierarchies. The integrability of the deformed equations is altered and a notion of weak integrability is introduced. We implement this scheme in the AKNS and SO(3) hierarchies and obtain known and new equations. Among them we found two important equations, the Camassa-Holm equation, viewed as a deformation of the KdV equation, and a deformation of the NLS equation.
Efficacy of a multi-dentate Schiff base and its vanadyl complex on various morphological and biochemical parameters of Vigna radiata L.
Creators: name: Acharjee, Kaushik
name: Sarkar, Jayanwita
name: Sinha, Biswajit
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: A N2O2 donor Schiff base polydentate ligand was synthesized by the condensation of benzidine and benzil in ethanolic medium. The formed ligand was condensed further with VOSO4.xH2O to get the corresponding vanadyl complex. Both the ligand and the complex were characterized by spectroscopic and elemental analyses. Mung bean (Vigna radiata L.) was selected as a plant material. Various morphological and biochemical parameters, e.g. leaf senescence assay, chlorophyll content, and different reactive oxygen species (ROS) were estimated and were compared to those with ammonium vanadate. Outcomes of the experiments revealed that the Schiff base complex has less toxic effects than ammonium vanadate on mung bean seedlings and provide better tolerance to vanadium toxicity. Though different stress marker and ROS accumulation were less and minimum pigment damage was noticed in the Schiff base complex-treated seedlings but the optimum positive impact largely depends on the dose. Beyond certain concentration, the complex may show inhibitory effects on the plants. Therefore, the present study revealed that heavy metal Schiff base complexes can be used as potential supplement to meet up micronutrient deficiency and at the same time such complexes can minimize the toxicity generated by application of different heavy metals.
Shadow of black hole surrounded by magnetized plasma: Axion-plasmon cloud
Creators: name: Khodadi, Mohsen
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: By exploiting the extreme environment of the black hole (BH) as a potential place for axion-photon interaction, we use an axion-producing model of the magnetized plasma to study the shadow of an asymptotically flat rotating BH immersed into an axion-plasmon cloud. By aiming to reveal footprints of axion in the dark shadow of BH, we in this paper explore the influence of the fixed axion-plasmon background on the motion of incident photons around the rotating BH. Under some free parameter settings, we find that axion-plasmon cloud around rotating BH affects the shape and size of the shadow in such a way that its role is distinguishable from non-magnetized plasma and standard vacuum solutions. By being limited to high rotation BH, we show that the size of the BH shadow increases as the axion-plasmon coupling gets strong. Interestingly, our analysis indicates that as the mass of axion gets heavier, it can leave a subtle imprint of itself on the shadow. Conversely, in the non-rotating limit (Schwarzschild), by recovering the spherical symmetry of the shadow shape of BH, its size decreases. In coordination with the trend of change in shadow size, the investigation of the energy emission from the BH surrounded by the magnetized plasma shows that the maximal energy emission rate from the rotating BH in the presence of axion-plasmon cloud increases compared to the non-magnetized plasma and the vacuum solutions. Subsequently, by relaxing the rotation, the axion-plasmon cloud causes a decrease in the energy emission rate from the BH.
description: 23 pages, 15 figures, for publication in " Nuclear Physics B"
Adeno-Associated Virus-Mediated Overexpression of LARGE Rescues α-Dystroglycan Function in Dystrophic Mice with Mutations in the Fukutin-Related Protein
Creators: name: Lu, Qi Long
name: Lu, Pei
name: Keramaris, Elizabeth
name: Vannoy, Charles H.
name: Xu, Lei
name: Xiao, Xiao
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Multiple genes (e.g., POMT1, POMT2, POMGnT1, ISPD, GTDC2, B3GALNT2, FKTN, FKRP, and LARGE) are known to be involved in the glycosylation pathway of α-dystroglycan (α-DG). Mutations of these genes result in muscular dystrophies with wide phenotypic variability. Abnormal glycosylation of α-DG with decreased extracellular ligand binding activity is a common biochemical feature of these genetic diseases. While it is known that LARGE overexpression can compensate for defects in a few aforementioned genes, it is unclear whether it can also rescue defects in FKRP function. We examined adeno-associated virus (AAV)-mediated LARGE or FKRP overexpression in two dystrophic mouse models with loss-of-function mutations: (1) Largemyd (LARGE gene) and (2) FKRPP448L (FKRP gene). The results agree with previous findings that overexpression of LARGE can ameliorate the dystrophic phenotypes of Largemyd mice. In addition, LARGE overexpression in the FKRPP448L mice effectively generated functional glycosylation (hyperglycosylation) of α-DG and improved dystrophic pathologies in treated muscles. Conversely, FKRP transgene overexpression failed to rescue the defect in glycosylation and improve the phenotypes of the Largemyd mice. Our findings suggest that AAV-mediated LARGE gene therapy may still be a viable therapeutic strategy for dystroglycanopathies with FKRP deficiency.
Projected dipole moments of individual two-level defects extracted using circuit quantum electrodynamics
Creators: name: Sarabi, Bahman
name: Ramanayaka, Aruna N.
name: Burin, Alexander L.
name: Wellstood, Frederick C.
name: Osborn, Kevin D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Material-based two-level systems (TLSs), appearing as defects in low-temperature devices including superconducting qubits and photon detectors, are difficult to characterize. In this study we apply a uniform dc-electric field across a film to tune the energies of TLSs within. The film is embedded in a superconducting resonator such that it forms a circuit quantum electrodynamical (cQED) system. The energy of individual TLSs is observed as a function of the known tuning field. By studying TLSs for which we can determine the tunneling energy, the actual $p_z$, dipole moments projected along the uniform field direction, are individually obtained. A distribution is created with 60 $p_z$. We describe the distribution using a model with two dipole moment magnitudes, and a fit yields the corresponding values $p=p_1= 2.8\pm 0.2$ Debye and $p=p_2=8.3\pm0.4$ Debye. For a strong-coupled TLS the vacuum-Rabi splitting can be obtained with $p_z$ and tunneling energy. This allows a measurement of the circuit's zero-point electric field fluctuations, in a method that does not need the electric-field volume.
description: Accepted to Physical Review Letters
Gene Therapy: Charting a Future Course—Summary of a National Institutes of Health Workshop, April 12, 2013
Creators: name: Kohn, Donald B.
name: Federoff, Howard J.
name: Vandenberghe, Luk H.
name: Asokan, Aravind
name: Abedi, Mehrdad
name: Zoloth, Laurie
name: Adusumilli, Prasad S.
name: Prograis, Lawrence
name: O'Reilly, Marina
name: Jambou, Robert
name: Boye, Shannon E.
name: Monahan, Paul
name: Gopal-Srivastava, Rashmi
name: Gargiulo, Linda
name: Gray, Jhanelle
name: Sena-Esteves, Miguel
name: Ikeda, Yasuhiro
name: Rosenthal, Eugene
name: Wierda, William
name: Harper, Scott Q.
name: Crystal, Ronald G.
name: Ahmed, Nabil
name: Montgomery, Maureen
name: Weber, Thomas
name: Popplewell, Leslie
name: Patterson, Amy P.
name: De Oliveira, Satiro
name: Adair, Jennifer
name: Goins, William F.
name: Sterman, Daniel H.
name: Tannous, Bakhos
name: Fong, Yuman
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Recently, the gene therapy field has begun to experience clinical successes in a number of different diseases using various approaches and vectors. The workshop Gene Therapy: Charting a Future Course, sponsored by the National Institutes of Health (NIH) Office of Biotechnology Activities, brought together early and mid-career researchers to discuss the key scientific challenges and opportunities, ethical and communication issues, and NIH and foundation resources available to facilitate further clinical advances.
Non-iterative rigid 2D/3D point-set registration using semidefinite programming
Creators: name: Khoo, Yuehaw
name: Kapoor, Ankur
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Optimization and Control (math.OC)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics
subject: G.1.6; I.4.9
subject: 90C22, 92C55

description: We describe a convex programming framework for pose estimation in 2D/3D point-set registration with unknown point correspondences. We give two mixed-integer nonlinear program (MINP) formulations of the 2D/3D registration problem when there are multiple 2D images, and propose convex relaxations for both of the MINPs to semidefinite programs (SDP) that can be solved efficiently by interior point methods. Our approach to the 2D/3D registration problem is non-iterative in nature as we jointly solve for pose and correspondence. Furthermore, these convex programs can readily incorporate feature descriptors of points to enhance registration results. We prove that the convex programs exactly recover the solution to the original nonconvex 2D/3D registration problem under noiseless condition. We apply these formulations to the registration of 3D models of coronary vessels to their 2D projections obtained from multiple intra-operative fluoroscopic images. For this application, we experimentally corroborate the exact recovery property in the absence of noise and further demonstrate robustness of the convex programs in the presence of noise.
description: 15 pages, 7 figures
K137R Mutation on Adeno-Associated Viral Capsids Had Minimal Effect on Enhancing Gene Delivery In Vivo
Creators: name: Zhao, Chunxia
name: Xiao, Xiao
name: Samulski, R. Jude
name: Li, Jianbin
name: Qiao, Chunping
name: Grieger, Joshua
name: Li, Juan
name: Bian, Tao
name: Li, Chengwen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The adeno-associated viral (AAV) vector has emerged as an attractive vector for gene therapy applications. Development of AAV vectors with enhanced gene transduction efficiency is important to ease the burden of AAV production and minimize potential immune responses. Rational mutations on AAV capsids have gained attention as a simple method of enhancing AAV transduction efficiency. A single-amino acid mutation, K137R, on AAV1 and AAV8 was recently reported to increase liver transgene expression by 5–10-fold. To determine whether the same mutation on other AAV serotypes would result in similar gene enhancement effects, K137R mutants were generated on AAV7, AAV8, and AAV9, and their effects were evaluated in vivo. Two reporter genes were utilized: the nuclear LacZ gene driven by the cytomegalovirus promoter and the luciferase gene driven by the CB promoter. Surprisingly, we found no difference in luciferase gene expression in the liver or other tissues using either the wild-type AAV8 capsid or AAV8-K137R. LacZ gene expression in the liver by AAV8-K137R was about onefold higher than that of wild-type AAV8. However, no difference was found in other tissues, such as skeletal muscle and cardiac muscle. In addition, no difference was found in transgene expression with either AAV7-K137R or AAV9-K137R mutants. Our results indicated that the K137R mutation on AAV7, AAV8, and AAV9 had minimal to no effect on transduction efficiency in vivo.
Adeno-Associated Virus at 50: A Golden Anniversary of Discovery, Research, and Gene Therapy Success—A Personal Perspective
Creators: name: Hastie, Eric
name: Samulski, R. Jude
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Fifty years after the discovery of adeno-associated virus (AAV) and more than 30 years after the first gene transfer experiment was conducted, dozens of gene therapy clinical trials are in progress, one vector is approved for use in Europe, and breakthroughs in virus modification and disease modeling are paving the way for a revolution in the treatment of rare diseases, cancer, as well as HIV. This review will provide a historical perspective on the progression of AAV for gene therapy from discovery to the clinic, focusing on contributions from the Samulski lab regarding basic science and cloning of AAV, optimized large-scale production of vectors, preclinical large animal studies and safety data, vector modifications for improved efficacy, and successful clinical applications.
Self-attractive semiflexible polymers under an external force field
Creators: name: Lamura, A.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: The dynamical response of a tethered semiflexible polymer with self-attractive interactions and subjected to an external force field is numerically investigated by varying stiffness and self-interaction strength. The chain is confined in two spatial dimensions and placed in contact with a heat bath described by the Brownian multiparticle collision method. For strong self-attraction the equilibrium conformations range from compact structures to double-stranded chains, and to rods when increasing the stiffness. Under the external field at small rigidities, the initial close-packed chain is continuously unwound by the force before being completely elongated. For double-stranded conformations the transition from the folded state to the open one is sharp being steeper for larger stiffnesses. The discontinuity in the transition appears in the force-extension relation as well as in the probability distribution function of the gyration radius. The relative deformation with respect to the equilibrium case along the direction normal to the force is found to decay as the inverse of the applied force.
description: Accepted for publication in Polymers
Employing a Gain-of-Function Factor IX Variant R338L to Advance the Efficacy and Safety of Hemophilia B Human Gene Therapy: Preclinical Evaluation Supporting an Ongoing Adeno-Associated Virus Clinical Trial
Creators: name: Wu, Zhijian
name: Gui, Tong
name: McPhee, Scott W.J.
name: Booth, Carmen J.
name: Sun, Junjiang
name: Kafri, Tal
name: Monahan, Paul E.
name: Hu, Genlin
name: Stafford, Darrel W.
name: Hannah, William B.
name: Suwanmanee, Thipparat
name: Samulski, R. Jude
name: Grieger, Joshua C.
name: Wichlan, David G.
name: Li, Chengwen
name: Samulski, Jade J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: AbstractVector capsid dose-dependent inflammation of transduced liver has limited the ability of adeno-associated virus (AAV) factor IX (FIX) gene therapy vectors to reliably convert severe to mild hemophilia B in human clinical trials. These trials also identified the need to understand AAV neutralizing antibodies and empty AAV capsids regarding their impact on clinical success. To address these safety concerns, we have used a scalable manufacturing process to produce GMP-grade AAV8 expressing the FIXR338L gain-of-function variant with minimal (<10%) empty capsid and have performed comprehensive dose–response, biodistribution, and safety evaluations in clinically relevant hemophilia models. The scAAV8.FIXR338L vector produced greater than 6-fold increased FIX specific activity compared with wild-type FIX and demonstrated linear dose responses from doses that produced 2–500% FIX activity, associated with dose-dependent hemostasis in a tail transection bleeding challenge. More importantly, using a bleeding model that closely mimics the clinical morbidity of hemophilic arthropathy, mice that received the scAAV8.FIXR338L vector developed minimal histopathological findings of synovitis after hemarthrosis, when compared with mice that received identical doses of wild-type FIX vector. Hemostatically normal mice (n=20) and hemophilic mice (n=88) developed no FIX antibodies after peripheral intravenous vector delivery. No CD8+ T cell liver infiltrates were observed, despite the marked tropism of scAAV8.FIXR338L for the liver in a comprehensive biodistribution evaluation (n=60 animals). With respect to the role of empty capsids, we demonstrated that in vivo FIXR338L expression was not influenced by the presence of empty AAV particles, either in the presence or absence of various titers of AAV8-neutralizing antibodies. Necropsy of FIX–/– mice 8–10 months after vector delivery revealed no microvascular or macrovascular thrombosis in mice expressing FIXR338L (plasma FIX activity, 100–500%). These preclinical studies demonstrate a safety:efficacy profile supporting an ongoing phase 1/2 human clinical trial of the scAAV8.FIXR338L vector (designated BAX335).
High-Pressure Transvenous Perfusion of the Upper Extremity in Human Muscular Dystrophy: A Safety Study with 0.9% Saline
Creators: name: Valley, Robert
name: Lin, Weili
name: An, Hongyu
name: Kocis, Keith
name: Chen, Yasheng
name: Muenzer, Joseph
name: Chopra, Manisha
name: Powers, William
name: Howard, James F.
name: Fan, Zheng
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: We evaluated safety and feasibility of high-pressure transvenous limb perfusion in an upper extremity of adult patients with muscular dystrophy, after completing a similar study in a lower extremity. A dose escalation study of single-limb perfusion with 0.9% saline was carried out in nine adults with muscular dystrophies under intravenous analgesia. Our study demonstrates that it is feasible and definitely safe to perform high-pressure transvenous perfusion with 0.9% saline up to 35% of limb volume in the upper extremities of young adults with muscular dystrophy. Perfusion at 40% limb volume is associated with short-lived physiological changes in peripheral nerves without clinical correlates in one subject. This study provides the basis for a phase 1/2 clinical trial using pressurized transvenous delivery into upper limbs of nonambulatory patients with Duchenne muscular dystrophy. Furthermore, our results are applicable to other conditions such as limb girdle muscular dystrophy as a method for delivering regional macromolecular therapeutics in high dose to skeletal muscles of the upper extremity.
Hunger and Meaning in the Novels of Cristina García
Creators: name: Pino, Alessandra
Publisher: name: University of Westminster
Year: 2022

description: This thesis offers a novel interpretation of the relationship between food and cultural memory starting from the concept of Gothic food and its relationship to colonialism. This work evolves from anthropologist Fernando Ortiz’s contribution to Cuban cultural memory and his metaphor of transculturación through Cuba’s national dish, the ajiaco. The ajiaco, a soup, will be considered in connection to slavery and forced labour on the sugar plantations in Cuba. It symbolises the amalgamation of all the different cultures that interacted on the island because of the colonisation of the indigenous populations and the slave trade starting from the arrival of Christopher Columbus. The Cuban food metaphor provides an opportunity to compare the different ways in which cultural memory operates and specifically how the metaphor has been translated outside of Cuba, through the work of Cuban-American diasporic writer Cristina García in the U.S. The five García novels I have selected to be the focus of this study are: Dreaming in Cuban (1992), The Agüero Sisters (1997), Monkey Hunting (2003), The Lady Matador’s Hotel (2010) and King of Cuba (2013). I consider these works to be representative of an idea of hunger that highlights the paradox of its contemporary attitudes to consumption and globalisation in light of colonialism and its legacies. The five novels selected for analysis exemplify how, in the specific context of the 1959 Cuban Revolution and its aftermath, food and consumption are carriers of a notion of hunger which harbours the violence of colonialism revived by revolutionary upheaval. The thesis introduces the original idea of “dark food”, exemplified by sugar, as a concept able to provide an insight into the legacies of slavery and its relationship to capitalism. The aim of this project is to recentre food in relation to models of memory that shed light on the negative consequences of globalization and capitalism. There is an infinite Western hunger for excess portrayed in García’s texts in contrast with the hunger for basic commodities in Cuba that provides the opportunity to discuss the conflation between an insatiable appetite and the losses caused by historical upheavals. The idea of dark food is to provide a lens through which it is possible to observe contrasts from a middle ground, a place that encapsulates how consumption can both passively and actively shed light on complex identitarian issues that allow for alternative interpretations of the past.
Ferret and Pig Models of Cystic Fibrosis: Prospects and Promise for Gene Therapy
Creators: name: Engelhardt, John F.
name: Olsen, John C.
name: Hu, Jim
name: Stewart, Zoe A.
name: Yan, Ziying
name: Sinn, Patrick L.
name: McCray, Jr., Paul B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Large animal models of genetic diseases are rapidly becoming integral to biomedical research as technologies to manipulate the mammalian genome improve. The creation of cystic fibrosis (CF) ferrets and pigs is an example of such progress in animal modeling, with the disease phenotypes in the ferret and pig models more reflective of human CF disease than mouse models. The ferret and pig CF models also provide unique opportunities to develop and assess the effectiveness of gene and cell therapies to treat affected organs. In this review, we examine the organ disease phenotypes in these new CF models and the opportunities to test gene therapies at various stages of disease progression in affected organs. We then discuss the progress in developing recombinant replication-defective adenoviral, adeno-associated viral, and lentiviral vectors to target genes to the lung and pancreas in ferrets and pigs, the two most affected organs in CF. Through this review, we hope to convey the potential of these new animal models for developing CF gene and cell therapies.
การวิจัยเชิงปฏิบัติการเพื่อส่งเสริมการเรียนรู้ในการจัดการศึกษาแบบมีส่วนร่วมขององค์กรในชุมชน: กรณีศึกษาชุมชนลำพญา จังหวัดนครปฐม
Creators: name: ศิริพร แย้มนิล
Publisher: name: College of Politics and Governance (COPAG), Mahasarakham University
Year: 2020
Subjects: Action Research
Promoting Learning
Participatory Education
Sustainable Development

description: Journal of Politics and Governance, 10, 1, 74-90
Translational Data from Adeno-Associated Virus-Mediated Gene Therapy of Hemophilia B in Dogs
Creators: name: Whitford, Margaret H.
name: Kay, Mark A.
name: Arruda, Valder R.
name: Nichols, Timothy C.
name: High, Katherine A.
name: Stedman, Hansell H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Preclinical testing of new therapeutic strategies in relevant animal models is an essential part of drug development. The choice of animal models of disease that are used in these studies is driven by the strength of the translational data for informing about safety, efficacy, and success or failure of human clinical trials. Hemophilia B is a monogenic, X-linked, inherited bleeding disorder that results from absent or dysfunctional coagulation factor IX (FIX). Regarding preclinical studies of adeno-associated virus (AAV)-mediated gene therapy for hemophilia B, dogs with severe hemophilia B (<1% FIX) provide well-characterized phenotypes and genotypes in which a species-specific transgene can be expressed in a mixed genetic background. Correction of the hemophilic coagulopathy by sustained expression of FIX, reduction of bleeding events, and a comprehensive assessment of the humoral and cell-mediated immune responses to the expressed transgene and recombinant AAV vector are all feasible end points in these dogs. This review compares the preclinical studies of AAV vectors used to treat dogs with hemophilia B with the results obtained in subsequent human clinical trials using muscle- and liver-based approaches.
CheepSync: A Time Synchronization Service for Resource Constrained Bluetooth Low Energy Advertisers
Creators: name: Sridhar, Sabarish
name: Misra, Prasant
name: Gill, Gurinder Singh
name: Warrior, Jay
Publisher: name: arXiv
Year: 2015
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Computer and information sciences

description: Clock synchronization is highly desirable in distributed systems, including many applications in the Internet of Things and Humans (IoTH). It improves the efficiency, modularity and scalability of the system, and optimizes use of event triggers. For IoTH, Bluetooth Low Energy (BLE) - a subset of the recent Bluetooth v4.0 stack - provides a low-power and loosely coupled mechanism for sensor data collection with ubiquitous units (e.g., smartphones and tablets) carried by humans. This fundamental design paradigm of BLE is enabled by a range of broadcast advertising modes. While its operational benefits are numerous, the lack of a common time reference in the broadcast mode of BLE has been a fundamental limitation. This paper presents and describes CheepSync: a time synchronization service for BLE advertisers, especially tailored for applications requiring high time precision on resource constrained BLE platforms. Designed on top of the existing Bluetooth v4.0 standard, the CheepSync framework utilizes low-level timestamping and comprehensive error compensation mechanisms for overcoming uncertainties in message transmission, clock drift and other system specific constraints. CheepSync was implemented on custom designed nRF24Cheep beacon platforms (as broadcasters) and commercial off-the-shelf Android ported smartphones (as passive listeners). We demonstrate the efficacy of CheepSync by numerous empirical evaluations in a variety of experimental setups, and show that its average (single-hop) time synchronization accuracy is in the 10us range.
Quantum field theoretical description for the reflectivity of graphene
Creators: name: Bordag, M.
name: Klimchitskaya, G. L.
name: Mostepanenko, V. M.
name: Petrov, V. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: High Energy Physics - Theory (hep-th)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We derive the polarization tensor of graphene at nonzero temperature in (2+1)-dimensional space-time. The obtained tensor coincides with the previously known one at all Matsubara frequencies, but, in contrast to it, admits analytic continuation to the real frequency axis satisfying all physical requirements. Using the obtained representation for the polarization tensor, we develope quantum field theoretical description for the reflectivity of graphene. The analytic asymptotic expressions for the reflection coefficients and reflectivities at low and high frequencies are derived for both independent polarizations of the electromagnetic field. The dependencies of reflectivities on the frequency and angle of incidence are investigated. Numerical computations using the exact expressions for the polarization tensor are performed and application regions for the analytic asymptotic results are determined.
description: 32 pages, 7 figures, 2 tables; sign errors in Eqs. (36) and (43) are corrected; the respective corrections are made in several equations of Secs. IV and V
เครือข่ายความร่วมมือในการบริหารจัดการน้ำเพื่อการเกษตรชุมชนบ้านท่างอย ตำบลบุ่งหวาย อำเภอวารินชำราบ จังหวัดอุบลราชธานี
Creators: name: ธีรพล พงษ์บัว
Publisher: name: College of Politics and Governance (COPAG), Mahasarakham University
Year: 2020
Subjects: Collaborative networks
Water management
Agriculture

description: Journal of Politics and Governance, 10, 1, 91-107
เปรียบเทียบการมีส่วนร่วมของประชาชนในการประเมินผลกระทบสิ่งแวดล้อมและสุขภาพระหว่างประเทศไทยและต่างประเทศ
Creators: name: คนางค์ คันธมธุรพจน์
Publisher: name: College of Politics and Governance (COPAG), Mahasarakham University
Year: 2020
Subjects: Environmental and Health Impact Assessment
Public Participation
Stakeholder

description: Journal of Politics and Governance, 10, 1, 108-126
แนวคิดเชิงจริยธรรมในโลกตะวันตก
Creators: name: ประโยชน์ ส่งกลิ่น
Publisher: name: College of Politics and Governance (COPAG), Mahasarakham University
Year: 2020
Subjects: Ethics
Ethical Concepts
Western World

description: Journal of Politics and Governance, 10, 1, 127-154
การพัฒนาผลสัมฤทธิ์การดำเนินงานตามเกณฑ์คุณภาพการบริหารจัดการภาครัฐของสถาบันการพลศึกษาจังหวัดสมุทรสาคร กระทรวงการท่องเที่ยวและกีฬา
Creators: name: กุลประภัสสร์ รำพึงจิตต์
Publisher: name: College of Politics and Governance (COPAG), Mahasarakham University
Year: 2020
Subjects: Management
Public Management Quality
Physical Education Institute

description: Journal of Politics and Governance, 10, 1, 155-169
An Asymptotic Preserving Two-Dimensional Staggered Grid Method for multiscale transport equations
Creators: name: Küpper, Kerstin
name: Frank, Martin
name: Jin, Shi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 82C70 41A60 65M12 65C20

description: We propose a two-dimensional asymptotic preserving scheme for linear transport equations with diffusive scalings. It is an extension of the time splitting developed by Jin, Pareschi and Toscani [SINUM,2000], but uses spatial discretizations on staggered grids, which preserves the discrete diffusion limit with a more compact stencil. The first novelty of this paper is that we propose a staggering in two dimensions that requires fewer unknowns than one could have naively expected. The second contribution of this paper is that we rigorously analyze the scheme of Jin, Pareschi, and Toscani [SINUM,2000] We show that the scheme is AP and obtain an explicit CFL condition, which couples a hyperbolic and a parabolic condition. This type of condition is common for asymptotic preserving schemes and guarantees uniform stability with respect to the mean free path. In addition, we obtain an upper bound on the relaxation parameter, which is the crucial parameter of the used time discretization. Several numerical examples are provided to verify the accuracy and asymptotic property of the scheme.
การพัฒนาทรัพยากรมนุษย์: การสื่อสารผ่านสื่อสังคมออนไลน์อย่างสร้างสรรค์
Creators: name: จีรศักดิ์ โพกาวิน
Publisher: name: College of Politics and Governance (COPAG), Mahasarakham University
Year: 2020
Subjects: Human Resources Development
Communication
Social media

description: Journal of Politics and Governance, 10, 1, 170-190
Common variations in noncoding regions of the human natriuretic peptide receptor A gene have quantitative effects
Creators: name: Sigel, Carlie
name: Maeda, Nobuyo
name: Erickson, Laurie
name: Guy, Vanessa
name: Wilder, Jennifer
name: Knowles, Joshua
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Genetic susceptibility to common conditions, such as essential hypertension and cardiac hypertrophy, is probably determined by various combinations of small quantitative changes in the expression of many genes. NPR1, coding for natriuretic peptide receptor A (NPRA), is a potential candidate, because NPRA mediates natriuretic, diuretic, and vasorelaxing actions of the nariuretic peptides, and because genetically determined quantitative changes in the expression of this gene affect blood pressure and heart weight in a dose-dependent manner in mice. To determine whether there are common quantitative variants in human NPR1, we have sequenced the entire human NPR1 gene and identified 10 polymorphic sites in its non-coding sequence by using DNA from 34 unrelated human individuals. Five of the sites are single nucleotide polymorphisms; the remaining five are length polymorphisms, including a highly variable complex dinucleotide repeat in intron 19. There are three common haplotypes 5’ to this dinucleotide repeat and three 3’ to it, but the 5’ haplotypes and 3’ haplotypes appear to be randomly associated. Transient expression analysis in cultured cells of reporter plasmids with the proximal promoter sequences of NPR1 and its 3’ untranslated regions showed that these polymorphisms have functional effects. We conclude that common NPR1 alleles can alter expression of the gene as much as two-fold and could therefore significantly affect genetic risks for essential hypertension and cardiac hypertrophy in humans.
การศึกษาศักยภาพบุคลากรเพื่อเตรียมพร้อมเข้าสู่องค์กรแห่งความสุขในกลุ่มคลัสเตอร์ ภาคเหนือตอนล่าง (พิษณุโลก พิจิตร เพชรบูรณ์ และสุโขทัย)
Creators: name: บุญลดา คุณาเวชกิจ
Publisher: name: College of Politics and Governance (COPAG), Mahasarakham University
Year: 2020
Subjects: Potential
Business Administration Program in the Lower Northern Cluster
Preparation for entering into a Happy Workplace
Lower Northern Cluster

description: Journal of Politics and Governance, 10, 1, 191-223
ทัศนะในการขอตำแหน่งทางวิชาการของคณาจารย์วิทยาลัยการเมืองการปกครองมหาวิทยาลัยมหาสารคาม
Creators: name: จีราวรรณ บุญคำภา
Publisher: name: College of Politics and Governance (COPAG), Mahasarakham University
Year: 2020
Subjects: Attitude on Academic Promotion
Academic Staff of College of Politics and Governance

description: Journal of Politics and Governance, 10, 1, 224-237
MPEC 2023-U160 : 2023 SL43
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 SL43

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Genetic influence on variation in serum uric acid in American Indians: the strong heart family study
Creators: name: Fabsitz, Richard R.
name: Haack, Karin
name: Lee, Elisa T.
name: Comuzzie, Anthony G.
name: Devereux, Richard B.
name: Voruganti, V. Saroja
name: Cole, Shelley A.
name: MacCluer, Jean W.
name: Best, Lyle G.
name: Almasy, Laura
name: Mottl, Amy
name: Howard, Barbara V.
name: Umans, Jason G.
name: Franceschini, Nora
name: Göring, Harald H. H.
name: Laston, Sandra
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Hyperuricemia is associated with the metabolic syndrome, gout, renal and cardiovascular disease (CVD). American Indians have high rates of CVD and 25 % of individuals in the Strong Heart Family Study (SHFS) have high serum uric acid levels. The aim of this study was to investigate the genetic determinants of serum uric acid variation in American Indian participants of the SHFS. A variance component decomposition approach (implemented in SOLAR) was used to conduct univariate genetic analyses in each of three study centers and the combined sample. Serum uric acid was adjusted for age, sex, age*sex, BMI, estimated glomerular filtration rate, alcohol intake, diabetic status and medications. Overall mean ± SD serum uric acid for all individuals was 5.14 ± 1.5 mg/dl. Serum uric acid was found to be significantly heritable (0.46 ± 0.03 in all centers, and 0.39 ± 0.07, 0.51 ± 0.05, 0.44 ± 0.06 in Arizona, Dakotas and Oklahoma, respectively). Multipoint linkage analysis showed significant evidence of linkage for serum uric acid on chromosome 11 in the Dakotas center (logarithm of odds score (LOD) = 3.02) and in the combined sample (LOD = 3.56) and on chromosome 1 (LOD = 3.51) in the combined sample. A strong positional candidate gene in the chromosome 11 region is solute carrier family22, member 12 (SLC22A12) that encodes a major uric acid transporter URAT1. These results show a significant genetic influence and a possible role for one or more genes on chromosomes 1 and 11 on the variation in serum uric acid in American Indian populations.