cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Muraenesocidae Kaup 1859
Creators: name: Ebersole, Jun A.
name: Cicimurri, David J.
name: Stringer, Gary L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Anguilliformes
Muraenesocidae

description: Muraenesocidae indet. Fig. 69 E–F
Material examined
UNITED STATES OF AMERICA – Alabama • 3 otoliths; GLS otolith comparative collection (2 specimens), MSC 39064.
Description
Shape best described as ovate (sensu Smale et al. 1995); height/length ratios approximately 60%. Length ranges from 6.5–7.5 mm. Margins smooth except for dorsal and posterodorsal margins, which may be coarsely lobed or crenulated. Anterior margin short and tapered. Anterodorsal margin slighted inflated, fairly steep, long. Dorsal margin short, irregularly lobed. Posterodorsal margin broadly rounded; posterior margin short, very slightly rounded outwardly, almost vertical. Posteroventral, ventral, anteroventral margins evenly but not deeply rounded. Inner face slightly convex, marked by conspicuous sulcus. Sulcus extending approximately 80% length of inner face; slightly flexed toward the posteroventral margin. Sulcus apparently undivided. Anterior upper margin of sulcus appears upwardly turning near anterodorsal margin. Posterior portion of sulcus more deeply excavated than anterior portion. Posterior end of sulcus rounded. Indications of possible crista superior. No ventral furrow visible. Outer face slightly convex, especially at center. Dorsal portion of outer face more undulating.
Remarks
Unfortunately, all three specimens are eroded, and it was difficult to ascertain detailed morphological features that would have assisted identification beyond the family level. Müller (1999) named Muraenesox rhomboideus from the Piney Point Formation of Virginia, which is Claibornian (Lutetian) in age.
Stratigraphic and geographic range in Alabama
This species was recovered only from the “upper” Lisbon Formation at site ACh-8. Bartonian, zones NP16 and NP17.
description: Published as part of Ebersole, Jun A., Cicimurri, David J. & Stringer, Gary L., 2019, Taxonomy and biostratigraphy of the elasmobranchs and bony fishes (Chondrichthyes and Osteichthyes) of the lower-to-middle Eocene (Ypresian to Bartonian) Claiborne Group in Alabama, USA, including an analysis of otoliths, pp. 1-274 in European Journal of Taxonomy 585 on page 189, DOI: 10.5852/ejt.2019.585, http://zenodo.org/record/3660259
Experiences of receiving formal psychological support following lower limb amputation: a qualitative study
Creators: name: Malouta, Rania
name: Bouquillon, Linda
name: Murray, Craig D.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: This study sought to explore the experiences of receiving formal psychological support following non-vascular-related lower limb amputation. Semi-structured interviews were conducted with five individuals (3 males, 2 females, aged 38–56) with lower limb loss. Two had unilateral above knee amputations, one a unilateral below knee amputation, one a unilateral through-knee amputation, and one had bilateral above knee amputations. Four had trauma-related amputations, one had an amputation due to cancer. All had received formal psychological support related to their amputation. Interpretative phenomenological analysis was used for the analysis of the data. Four themes were developed: (1) The need for psychological intervention—denial and acceptance; (2) “Safe space”—being valued, heard, and validated; (3) The importance of focus, transparency, and specialist knowledge; and (4) The most helpful techniques and approaches. Findings highlighted aspects of psychological support that were helpful and unhelpful. The findings provide insights into how psychological support for people with lower limb amputation can be delivered or improved. These include: the importance of psychological support throughout rehabilitation; the benefit of transparency and collaborative goal setting in sessions; and participants’ preference that those providing formal psychological support have limb loss specific knowledge. Psychological support for lower limb amputation needs to be provided throughout the rehabilitation process.Transparency regarding the stages of therapy, models used, and decisions made as well as collaborative goal setting need to be incorporated in psychological sessions.Psychologists and other mental health professionals offering support to individuals with lower limb amputation need to have specialist knowledge on limb loss and its psychological entailments. Psychological support for lower limb amputation needs to be provided throughout the rehabilitation process. Transparency regarding the stages of therapy, models used, and decisions made as well as collaborative goal setting need to be incorporated in psychological sessions. Psychologists and other mental health professionals offering support to individuals with lower limb amputation need to have specialist knowledge on limb loss and its psychological entailments.
D5.3 Use-case Plan, Reports & Recommendations
Creators: name: Karvounis, Manos
Publisher: name: Zenodo
Year: 2024

description: This deliverable outlines the methodologies for piloting and evaluating the EFRA use-cases and also describes the specific scenarios that will be tested, along with the activities and Key Performance Indicators (KPIs) associated with them. The methodology comprises two distinct evaluation phases: formative and summative, each targeting different stages of the use-case development.

The formative evaluation focuses on the early development stages, involving user interaction with preliminary tool versions. This phase is pivotal for gauging initial performance through KPIs like accuracy, AI model efficacy, and usability. Feedback from this phase, particularly from decision-makers, is integral for refining the tools, paving the way for the second cycle. The summative evaluation then assesses the final tool versions, aiming to validate their compliance with targeted KPIs, such as enhanced accuracy, user satisfaction, and overall business impact. This phase is crucial for confirming the technical robustness and practical utility of the developed tools in real-world settings.

Parallel to these methodologies, the deliverable presents concrete use-cases that will undergo these piloting phases. These include scenarios like root cause analysis for salmonella in poultry farms, enhanced predictive capabilities for pest alarms, and automated regulatory analysis. Each use-case is accompanied by specific activities designed to test and refine the tools in question.

For instance, the poultry farm use-case involves leveraging historical data and AI algorithms to predict salmonella outbreaks, with KPIs focusing on model accuracy and user satisfaction. Similarly, the pest alarm enhancement scenario aims to improve prediction algorithms using diverse data, with real-life tests planned to evaluate the model's accuracy and efficiency. The automated regulatory analysis module targets reducing manual effort in data interpretation, with KPIs focusing on the accuracy of automated summaries and user time saved.

In summary, this deliverable lays out a structured approach to piloting and evaluating EFRA tools and details the specific use-cases that will be put to the test. It highlights the planned activities and KPIs for each scenario, ensuring a comprehensive and focused approach to validating and enhancing the project's outputs. Through this dual emphasis on methodology and practical application, EFRA aims to deliver solutions that are technically sound and directly applicable and beneficial in addressing realworld challenges in the food safety and risk prevention sectors.
Dysoxylum loureiroi Pierre ex Laness., Pl. Util. Col. Franç.
Creators: name: Holzmeyer, Laura
name: Hauenschild, Frank
name: Mabberley, David J.
name: Muellner-Riehl, Alexandra N.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Sapindales
Meliaceae
Dysoxylum
Dysoxylum loureiroi

description: 10. Dysoxylum loureiroi (Pierre) Pierre ex Laness., Pl. Util. Col. Franç.: 309. 1886
≡ Epicharis loureiroi Pierre in Bull. Mens. Soc.Linn.Paris 1:291.1881 – Type: Vietnam, Dong Nai Prov., Bien Hoa, Pierre 1646 (syntypes: P barcodes P00476761 [image!], P06672122 [image!], P06672124 [image!], P06672125 [image!], P06672126 [image!], P06672128 [image!], P06672130 [image!], P06672131 [image!]).
Distribution. – Cambodia and S Vietnam.
description: Published as part of Holzmeyer, Laura, Hauenschild, Frank, Mabberley, David J. & Muellner-Riehl, Alexandra N., 2021, Confirmed polyphyly, generic recircumscription and typification of Dysoxylum (Meliaceae), with revised disposition of currently accepted species, pp. 1248-1272 in TAXON 70 (6) on page 1263, DOI: 10.1002/tax.12591, http://zenodo.org/record/14047415
Heat shock proteins as biomarkers of lung oxidant stress
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Tobacco smoke is comprised of many different compounds that are potentially harmful to the lung. As a matter of fact both the smoke taken in by smokers, as well as the second-hand smoke that others in the vicinity are exposed to, contains over 4000 potentially toxic agents. One of the major ways that many of these materials can cause injury is by oxidant damage. Oxidant damage occurs when oxygen atoms in the cell, either free and on their own (or as part of another molecule), become reactive and interact with many other molecules in the cells. The first line of defense for cells is to “soak” up this damaging oxygen by allowing it to react with an abundant cellular molecule without harming the cell. Glutathione (GSH) is such an abundant molecule found in cells. Heat shock proteins (Hsps) are another important group of proteins in cells that are capable of repairing damage to the cell from oxidants if GSH is unable to prevent this injury. Hsps have also been found to have the potential to protect both individual cells and the intact lung from injury if they can be produced prior to exposure to potentially damaging conditions. Levels of GSH in tissues are important in the initial protection of animals from oxidant injury, and Hsps seem to be associated with this protective attempt. It would be valuable if we could use the easily detectable presence of Hsps as biomarkers of evidence of tobacco oxidant exposure in the lung. The smallest airways of the lung, the terminal bronchioles, are the last portion of the lung that inhaled materials pass through before the air, and materials in it, reach the region of gas exchange. A common cell type in the terminal bronchiole, the Clara cell, is capable of taking pollutants in tobacco smoke or other forms of air pollution and converting them into another, potentially more toxic material in an attempt to rid the body of them. Naphthalene (NA) is an example of a very common toxin in tobacco smoke that the Clara cell tries to break down, but instead creates other compounds that can cause oxidant injury in the lung. Because of this we will use NA to recreate a potential scenario in the lung that mimics the changes that may occur after tobacco use. This will address a priority of TRDRP, the issue of biomarkers in lung injury after exposure to an important constituent found in tobacco smoke. Additionally we expect to gain considerable knowledge about how the lung protects itself from tobacco constituent-induced lung injury. Our aim is to provide, through these studies, some insight into how tobacco smoke interacts with two of the critical protective measures taken by the lung; further we will attempt to identify a valuable biomarker of oxidant stress and tissue injury after exposure to an abundant tobacco smoke constituent.
Ariosoma Swainson 1838
Creators: name: Ebersole, Jun A.
name: Cicimurri, David J.
name: Stringer, Gary L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Anguilliformes
Congridae
Ariosoma

description: Genus Ariosoma Swainson, 1838
Type species
Ophisoma acuta Swainson, 1838, Recent.
description: Published as part of Ebersole, Jun A., Cicimurri, David J. & Stringer, Gary L., 2019, Taxonomy and biostratigraphy of the elasmobranchs and bony fishes (Chondrichthyes and Osteichthyes) of the lower-to-middle Eocene (Ypresian to Bartonian) Claiborne Group in Alabama, USA, including an analysis of otoliths, pp. 1-274 in European Journal of Taxonomy 585 on page 189, DOI: 10.5852/ejt.2019.585, http://zenodo.org/record/3660259
Liriomyza cracentis Lonsdale
Creators: name: Eiseman, Charles S.
name: Lonsdale, Owen
name: Linden, John Van Der
name: Feldman, Tracy S.
name: Palmer, Michael W.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Agromyzidae
Liriomyza
Liriomyza cracentis

description: Liriomyza cf. cracentis Lonsdale
(Fig. 74)
Material examined. ILLINOIS: Cook Co., Glencoe, Chicago Botanic Gardens, McDonald Woods, 42°8′56.66″N 87°47′21.99″W, 12.vi.2018, em. by 27.vi.2018, J.F. Steffen, ex Eupatorium rugosum, CNC 1135572 (1♁).
Hosts. The label of the Liriomyza cracentis holotype indicates a host of “ Euperomum maculata ”, possibly referring to Eupatorium maculatum, a synonym of Eutrochium maculatum (L.) E.E.Lamont (Asteraceae) (Lonsdale 2017a). The Illinois specimens were reared from Ageratina altissima (L.) R.M.King & H.Rob., which like Eutrochium is in the tribe Eupatorieae.
Leaf mine. (Fig. 74) Upper-surface, greenish to whitish, entirely narrow and linear; the photographs provided by J. Steffen do not show the entire mines, but no frass is evident in the portions photographed.
Puparium. Details not recorded, but presumably formed outside the mine.
Phenology and voltinism. All known specimens tentatively identified as Liriomyza cracentis have been reared or captured between late June and mid-July. Larvae are present in June.
Distribution. The Liriomyza cracentis holotype was collected in Canada: QC, and a tentatively identified male was collected in ON. The new material is from USA: IL; also see Comments below.
Comments. Based on the host, leaf mine, and adult characters, this fly is possibly conspecific with the Massachusetts female discussed by Eiseman & Lonsdale (2018) as Liriomyza sp. 2; the mines in both cases seem consistent with Spencer & Steyskal’s (1986) unidentified leaf mine #4 (known from DC, MN, and WI). We should note, however, that the photographed mines are not the exact ones from which the Illinois specimen was reared; no host material was preserved, and after the adult emerged, J. Steffen returned to the group of plants from which the mines had been collected and photographed old, vacated mines that at least superficially resembled them.
description: Published as part of Eiseman, Charles S., Lonsdale, Owen, Linden, John Van Der, Feldman, Tracy S. & Palmer, Michael W., 2021, Thirteen new species of Agromyzidae (Diptera) from the United States, with new host and distribution records for 32 additional species, pp. 1-68 in Zootaxa 4931 (1) on page 25, DOI: 10.11646/zootaxa.4931.1.1, http://zenodo.org/record/4545337
Dysoxylum malabaricum Hiern
Creators: name: Holzmeyer, Laura
name: Hauenschild, Frank
name: Mabberley, David J.
name: Muellner-Riehl, Alexandra N.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Sapindales
Meliaceae
Dysoxylum
Dysoxylum malabaricum

description: 13. * Dysoxylum malabaricum Bedd. ex Hiern in Hooker, Fl. Brit. India 1: 548. 1875
– Holotype: India, Tamil Nadu, Beddome s.n. (K barcode K000657046!).
Distribution. – S India.
Note. – Closely allied to Dysoxylum ficiforme.
description: Published as part of Holzmeyer, Laura, Hauenschild, Frank, Mabberley, David J. & Muellner-Riehl, Alexandra N., 2021, Confirmed polyphyly, generic recircumscription and typification of Dysoxylum (Meliaceae), with revised disposition of currently accepted species, pp. 1248-1272 in TAXON 70 (6) on page 1263, DOI: 10.1002/tax.12591, http://zenodo.org/record/14047415
Hungarian Roma and African American autobiographiesin comparative perspective
Creators: name: Demeny, Tamas
Publisher: name: No Publisher Supplied
Year: 2011

description: My dissertation is a comparative study of the following Hungarian Roma and African American autobiographies: Menyhért Lakatos's Smoky Pictures, Hilda Péliné Nyári's My Little Life, Richard Wright's Black Boy, and Zora Neale Hurston's Dust Tracks on a Road. I use the rich critical literature on African American autobiographies to better understand Gypsy autobiographies, about which there is a paucity of literary scholarship. I make use of the latest developments in theoretical writings about the genre ofautobiography, particularly autoethnography. So, my study is a groundbreaking work on Hungarian Roma autobiographies, and my comparative method brings an original contribution to the fields of comparative literature and cross-cultural ethnic studies. My dissertation focuses, on the one hand, on how the Hungarian Roma and African American authors grapple with ways to understand their own cultures and presenttheir experiences and insights, and, on the other hand, on the equally complex presentations of contacts with the majority cultures. The authors search for ways to reveal the dynamics of their cultures and their special positions within them, using the language,cultural productions, and ideologies of the majority culture, finding ways to express things that are often unthinkable in the majority culture's understanding of the world. A study of the narrators' relationships with their mothers and families opens up ways ofunderstanding the complexities of their own cultures and their complicated relationships to these cultures. While descriptions of the relationships with the mothers are readily accessible to most readers, these descriptions point beyond themselves to the complicated and emotionally charged relationships to the cultures. The presentation of intercultural encounters is equally unique and difficult in eachcase, as the subject of the minority culture describes experiences of oppression and disadvantaged status. Experiences of poverty, isolation, disrespect, and lack of access to education can be difficult to transmit because these experiences penetrate the deepest levels of one's being. I study the presentations of violence because violent experiences are palpable and emotional ways of encountering oppression at the hands of the majorityculture. The understanding thus gained can explain the varying attitudes towards resistance among the four authors.
Dysoxylum macrocarpum G. Don, Gen. Hist.
Creators: name: Holzmeyer, Laura
name: Hauenschild, Frank
name: Mabberley, David J.
name: Muellner-Riehl, Alexandra N.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Sapindales
Meliaceae
Dysoxylum
Dysoxylum macrocarpum

description: 11. Dysoxylum macrocarpum (Spreng.) Blume ex G.Don, Gen. Hist. 1: 683. 1831
≡ Trichilia macrocarpa Spreng., Syst. Veg. 4(2): 252. 1827 – Lectotype (designated by Mabberley in Soepadmo & al., Tree Fl. Sabah Sarawak: 167. 2007): Indonesia, Java, G. Salak, Blume s.n [“ 527 ”; acc. 903295229] (L barcode L 0017232!).
Distribution. – Thailand and Sumatra to Philippines andSulawesi.
Note. – See also: Mabberley (2013a: 214).
description: Published as part of Holzmeyer, Laura, Hauenschild, Frank, Mabberley, David J. & Muellner-Riehl, Alexandra N., 2021, Confirmed polyphyly, generic recircumscription and typification of Dysoxylum (Meliaceae), with revised disposition of currently accepted species, pp. 1248-1272 in TAXON 70 (6) on page 1263, DOI: 10.1002/tax.12591, http://zenodo.org/record/14047415
MIR-9 targets OC2 in proliferating and differentiating neural stem cells
Creators: name: Davila, Jorge
Publisher: name: No Publisher Supplied
Year: 2011

description: MicroRNAs are key regulators of biological processes. In this thesis we identify mir-9 as a critical regulator during NSC proliferation and neuronal differentiation. Interestingly the role of mir-9 in NSCs differs depending on our experimental model. In a rat multipotential NSC, exogenous expression of mir-9 alone can enhance their neurogenic capacity. Meanwhile, in human NSCs mir-9 plays a role in NSC maintenance. These results either suggest that the role of mir-9 is not conserved across species or most likely that mir-9 can exert different cellular functions depending on the cellular context. In H1 NSCs subpopulations of cells expressing different combinations of proliferation and/or differentiation markers in cultures of neuronal differentiating cells were identified. The combined expression of differentiating and proliferating markers is a clear indication that differentiation is a “fluid” process that requires multiple overlapping steps to reach a specific phenotype. In addition, we identified OC2 as an anti-neuronal gene. Its mRNA is associated with the RISC complex during NSC neuronal differentiation where mir-9 serves to reduce OC2 protein output. These data together show that mir-9 serves to regulate NSCs in a context dependent manner and that it can canalyze neuronal differentiation by inhibiting genes that would prevent or retard neuronal differentiation.
Ariosoma nonsector - Nolf & Stringer 2003
Creators: name: Ebersole, Jun A.
name: Cicimurri, David J.
name: Stringer, Gary L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Anguilliformes
Congridae
Ariosoma
Ariosoma nonsector

description: Ariosoma nonsector Nolf & Stringer, 2003
Fig. 69 G–H
Otolithus (Platessae) sector Koken, 1888: 292, pl. 17, figs 5–16.
Ariosoma sp. – Stringer 1979: 102, pl. 1, fig. 4; 1986: 213, pl. 3, fig. 2.
Ariosoma nonsector – Nolf & Stringer 2003: 7, pl. 2, figs 1a–6. — Nolf 2003: 3–4, pl. 1, figs 3–4; 2013: 35–37, pl. 21.
Material examined
UNITED STATES OF AMERICA – Alabama • 11 otoliths; GLS otolith comparative collection (10 specimens), MSC 39069.
Description
Species characterized by massive otoliths; height nearly the same as the length, with height/length ratios ranging from 80–86%. Margins typically smooth. Ostial rim slightly concave, most specimens exhibiting some concavity at posterodorsal rim. Posterior margin tends to taper. Ventral rim broadly rounded, marked by distinctive angular central position. Inner face mainly smooth, convex, except for some irregular depressions in upper portion of dorsal area. Sulcus wide, only slightly incised. Sulcus extends from very near anterior margin to posterior (about 85% of sagitta length). Sulcus entirely filled with colliculum, except for dorsal extremity of ostial channel. No clear division of ostial and caudal portions of sulcus. Posterior end of sulcus broadly tapered but showing some widening ventrally. No indications of ventral furrow. Outer face smooth, convex except for area near posterior end, where shallow dorsoventrally oriented depression occurs.
Remarks
This species and Paraconger sector (see below) were originally described as one species by Koken (1888), but Ariosoma nonsector was separated by Nolf & Stringer (2003). This taxon is known from middle and upper Eocene deposits in Alabama, Louisiana, Mississippi, and Virginia in the USA, and it occurs in lower Oligocene (Rupelian) strata of Alabama, Louisiana, and Mississippi.
Stratigraphic and geographic range in Alabama
Ariosoma nonsector is known only from the “upper” Lisbon Formation at sites ACh-8 and ACl-4. The lack of A. nonsector in the Gosport Sand may be related to the very sandy nature of the formation or the lack of extensive bulk sampling. Bartonian, zones NP16 and NP17.
description: Published as part of Ebersole, Jun A., Cicimurri, David J. & Stringer, Gary L., 2019, Taxonomy and biostratigraphy of the elasmobranchs and bony fishes (Chondrichthyes and Osteichthyes) of the lower-to-middle Eocene (Ypresian to Bartonian) Claiborne Group in Alabama, USA, including an analysis of otoliths, pp. 1-274 in European Journal of Taxonomy 585 on pages 189-190, DOI: 10.5852/ejt.2019.585, http://zenodo.org/record/3660259
Mechanism of apparent long-term nicotinic inactivation
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Nicotine is an important psychologically rewarding substance in tobacco. The action of nicotine on brain nicotinic receptors drives the habitual use of tobacco. Nicotine exposure for different times and at different doses is reported to produce a range of physiological effects in laboratory animals and humans ranging from elevated locomotor activity, seizures, changes in body temperature, enhancement of cognition and attention, relief of depression, and anxiolysis.

 Tolerance and withdrawal symptoms are two important features of nicotine addiction. Tolerance is the reduction in drug response that occurs after chronic exposure. Withdrawal symptoms are the adverse side-effects that occur after chronic drug exposure ends. The development of nicotine tolerance forces smokers to increase their nicotine intake to compensate for the reduced psychological effects of the drug. It also contributes to habitual smoking by reducing the adverse physiological effects of nicotine. Withdrawal symptoms also contribute to nicotine addiction by making smoking cessation more traumatic.

 Nicotine addiction, like any other biological disorder, cannot be cured until we know its biological basis. Nicotine receptors are normally activated by a chemical messenger called acetylcholine. After long nicotine exposures, it takes a long-time for these receptors to be able to respond to acetylcholine. Taking in more nicotine partially compensates for this loss of inactive receptors. Thus, the development of nicotine tolerance increases the number of cigarettes, a smoker must smoke to maintain a constant psychological reward from nicotine.

 The goal of our research is to study the mechanism responsible for apparent long-term nicotinic receptor inactivation. We hypothesize that the long-lasting effects of nicotine on brain nicotinic receptors are due to the release of nicotine from brain neurons that have taken up nicotine. Our experiments will test this hypothesis and determine if this mechanism is a factor in persistent nicotine tolerance in smokers.
Staying French
Creators: name: Daily, Andrew M. (Michael)
Publisher: name: No Publisher Supplied
Year: 2011

description: In 1946, following the Second World War, France initiated a series of constitutional reforms designed to bind the French empire more closely to the Frenchnation. As part of these reforms, the islands of Martinique and Guadeloupe – French colonies since the early 17th century – were formally incorporated into the French nation as “Overseas Departments,” juridically no different than the departments of mainlandFrance. The push for incorporation, which came to be known as assimilation, was led by prominent anti-colonial, Communist and negritude intellectuals and activists. They believed that assimilation constituted the surest means to break down the economic, social and cultural barriers between the Antilles and France. Incorporation into theFrench state promised economic and social improvements as well as increasedopportunities for Antilleans to work, study and participate in French life. Assimilationwas imagined not as an extension of colonialism but as a form of decolonization. However, the promised social and economic improvements never materialized and in the 1950s Antilleans grew disenchanted with assimilation and its failed promises. This project analyzes Antillean intellectuals’, students’ and activists’dissatisfaction with assimilation and their turn towards an overtly anti-colonial politics that posited the Antilles as separate from France. My project explores how a small people positioned and made sense of themselves in the tumultuous years of decolonization, the Cold War, world revolution and the new social movements. In order to combat Frenchcolonialism, Antilleans worked to build links with anti-colonial movements in Africa and Latin America, as well as the civil rights movement in the United States. Thinking of themselves as colonized subjects inspired an intellectual and cultural movement amongAntillean intellectuals that turned away from France and toward the Americas to study their cultural and racial identity in order to make sense of themselves as simultaneously black and European, Antillean and French, subject and citizen. My dissertationdemonstrates how this turn inward profoundly shaped Antillean culture, particularly Antillean literature and philosophy, and led to the discovery of Antilleans’ “OtherAmericanness.”
The long and winding road
Creators: name: Cronheim, Carol C.
Publisher: name: No Publisher Supplied
Year: 2011

description: This dissertation examines for the first time the impact of a 1999 statute that created General Operating Support (GOS) grants for historic sites and organizations in New Jersey, as well as a law passed in 2000 that created the New Jersey CulturalTrust to help financially stabilize arts and history organizations. The research question addressed examines what effect GOS grants have had on historyorganizations as a group and on those organizations that directly received GOS grants. In addition, this dissertation examines what effect the creation of the New Jersey Cultural Trust has had on the cultural community1 in New Jersey. Direct subsidies for culture have been called into question, but such research does not address cultural spending financed through a tax or fee that is specifically earmarked for that purpose, as is the case in New Jersey with the Hotel/Motel Occupancy Fee. The research method employed was a statewide survey of arts and history organizations in the state. The results indicate that history organization are in better financial condition and are better able to serve the public through increased programming and staffing than before operating grants were available to them.Public funding did not “crowd out” private funding as some literature suggests. More dollars are out in the economy as a result of a more financially hearty historycommunity, but economic impact studies show that the effect per million dollars in expenditures does not have as large an economic impact as it did ten years earlier.This finding, however, is true for many other industries, mainly because of the increasingly global economy. For the arts and history, a critical mass of funding isnecessary to create a positive economic impact, both for state agencies and for their grantees. The data show that we have not yet reached that critical mass. The research also shows that arts and history organizations have thought more about their long-termfinancial future and stability since the creation of the New Jersey Cultural Trust.This finding holds even if an organization only applied for but did not receive a grantfrom the Cultural Trust.
Dysoxylum magnificum Mabb.
Creators: name: Holzmeyer, Laura
name: Hauenschild, Frank
name: Mabberley, David J.
name: Muellner-Riehl, Alexandra N.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Sapindales
Meliaceae
Dysoxylum
Dysoxylum magnificum

description: 12. Dysoxylum magnificum Mabb. in Blumea 38: 309. 1994 –
Holotype: Malaysia, Sarawak, First Divn, 12th mi Penrissen rd, Sibatak Luang S24337 (FHO barcode 00125323G!).
Distribution. – Sumatra to Sarawak.
Note. – See also Mabberley (2013a: 215).
description: Published as part of Holzmeyer, Laura, Hauenschild, Frank, Mabberley, David J. & Muellner-Riehl, Alexandra N., 2021, Confirmed polyphyly, generic recircumscription and typification of Dysoxylum (Meliaceae), with revised disposition of currently accepted species, pp. 1248-1272 in TAXON 70 (6) on page 1263, DOI: 10.1002/tax.12591, http://zenodo.org/record/14047415
NMDA receptor mediated expression of Arc in dorsal and ventral hippocampus contributes to the acquisition of contextual and trace fear conditioning
Creators: name: Czerniawski, Jennifer
Publisher: name: No Publisher Supplied
Year: 2011

description: The dorsal and ventral subregions of the hippocampus are differentially involved in several of types of learning, including fear conditioning. For example, we have previously demonstrated that the integrity of ventral, but not dorsal, hippocampus is necessary for the acquisition and expression of trace fear conditioning while dorsal, but not ventral, hippocampus is critically involved in spatially-guided reinforced alternation (Czerniawski, Yoon & Otto, 2009). In contrast to the partially dissociable effects of either lesions or inactivation, however, several lines of research suggest that, in intact subjects, both subregions are normally involved in the acquisition of many hippocampal-dependent tasks. The present studies investigated the molecular basis of these forms of learning by determining whether NMDA receptor-mediated immediate early gene expression in dorsal vs. ventral hippocampus contributes to the acquisition and/or retention of trace and contextual fear conditioning. In the first set of experiments we examined the effect of NMDA receptor antagonism in dorsal or ventral hippocampus on the acquisition or expression of trace and contextual fear conditioning. Next we assessed if trace fear conditioning alters the transcription and/or translation of Arc, an immediate early gene thought to be critically involved in some forms of plasticity and learning. In addition we examined the effect of blocking Arc translation with antisense oligodeoxynucleotides on the acquisition of CS-US associations in this paradigm. Lastly, in the final experiment we determined if the learning induced increase in Arc translation is NMDA receptor-dependent. The results of these studies suggest that both NMDA-receptor antagonism and the infusion of antisense oligodeoxynucleotides for the immediate early gene Arc (activity-regulated cytoskeletal protein) into dorsal or ventral hippocampus impair the acquisition of contextual and trace fear conditioning. In addition, trace fear conditioning enhances both Arc transcription and translation. Finally, pre-training infusions of either Arc antisense oligodeoxynucleotides or the NMDA receptor antagonist APV block the learning-induced enhancement of Arc. Together these studies support the notion that NMDA-receptor mediated expression of the immediate early gene Arc in both dorsal and ventral hippocampus may underlie the acquisition of a variety of forms of hippocampal dependent learning.
Impact of nicotinic signaling on neuronal gene expression
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Tobacco smoking is the leading preventable cause of death and disease in the United States. Nicotine present in tobacco has been identified as the primary component driving its continued use despite harmful effects, but the mechanism behind nicotine abuse is not well understood. Nicotine exerts its effects in the body by acting on a family of proteins called nicotinic receptors that are responsible for relaying signals. These receptors are present on neurons and are activated by chemicals normally found in the body, namely acetylcholine. Acetylcholine can bind to and open nicotinic receptors, thereby allowing ions, including calcium, to flow into the neurons. This influx of ions can generate currents to further relay information electrically; the flow of calcium may be important for many cellular processes, such as producing changes in gene output. When these nicotinic receptors are inappropriately activated or blocked, neurological disorders such as Alzheimer’s disease, Parkinson’s disease, and schizophrenia may result. Thus, nicotinic receptors are potentially important for normal brain function.

 The experiments proposed here will allow us to better understand the role of nicotinic receptors in calcium-induced changes in gene expression and the pathways involved in information transfer. We will examine the ability of nicotine to change the activity of a factor important for gene expression, as well as identify the individual genes that have altered expression following nicotine treatment. In addition, experiments will be performed to correlate the extent of receptor activity to the degree of changes in gene expression. Since many aspects of nicotine and drug abuse have been related to changes in gene products within brain cells, the information obtained from these studies will allow us to gain insights into the mechanisms behind nicotine addiction and toxicity.
Back-analysis of crossrail deep excavations using 3D FE modelling—development of BRICK parameters for London clay
Creators: name: Chen, Y
name: Biscontin, G
name: Pillai, AK
name: Nicholson, DP
Publisher: name: CRC Press
Year: 2018
Subjects: 40 Engineering
4019 Resources Engineering and Extractive Metallurgy

description: New underground stations up to 40 m deep for the Crossrail project in the London have been constructed. Excavations were supported by diaphragm walls or secant pile wall, using either the top-down or bottom-up construction sequence. To investigate the effects of these deep excavations on the existing adjacent buildings and tunnels, 3D FE models have been developed. The non-linear elastic plastic soil constitutive model – BRICK was used to model the behavior of London Clay and Lambeth Group. A back-analysis of the field inclinometer data from Tottenham Court Road Station – Western Ticket Hall was carried out using the 3D FEM. Revised BRICK parameters were derived from the back-analysis and applied in three other Crossrail excavations. The back analysis of four excavations has provided an intensive review on the BRICK model parameters for London Clay. The reliability of the BRICK model in London Clay to assess most probable ground movements has been demonstrated.
Dysoxylum oppositifolium F. Muell., Fragm.
Creators: name: Holzmeyer, Laura
name: Hauenschild, Frank
name: Mabberley, David J.
name: Muellner-Riehl, Alexandra N.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Sapindales
Meliaceae
Dysoxylum
Dysoxylum oppositifolium

description: 14. Dysoxylum oppositifolium F.Muell., Fragm. 5: 177. 1866
– Syntypes: Australia, Queensland, Rockingham Bay, Dallachy s.n. (MEL, several sheets).
Distribution. – Philippines to New Guinea and NE Australia.
Note. – See also Mabberley (2013b: 31).
description: Published as part of Holzmeyer, Laura, Hauenschild, Frank, Mabberley, David J. & Muellner-Riehl, Alexandra N., 2021, Confirmed polyphyly, generic recircumscription and typification of Dysoxylum (Meliaceae), with revised disposition of currently accepted species, pp. 1248-1272 in TAXON 70 (6) on page 1263, DOI: 10.1002/tax.12591, http://zenodo.org/record/14047415
Paraconger Kanazawa 1961
Creators: name: Ebersole, Jun A.
name: Cicimurri, David J.
name: Stringer, Gary L.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Anguilliformes
Congridae
Paraconger

description: Genus Paraconger Kanazawa, 1961
Type species
Echelus caudilimbatus Poey, 1867, Recent.
description: Published as part of Ebersole, Jun A., Cicimurri, David J. & Stringer, Gary L., 2019, Taxonomy and biostratigraphy of the elasmobranchs and bony fishes (Chondrichthyes and Osteichthyes) of the lower-to-middle Eocene (Ypresian to Bartonian) Claiborne Group in Alabama, USA, including an analysis of otoliths, pp. 1-274 in European Journal of Taxonomy 585 on page 190, DOI: 10.5852/ejt.2019.585, http://zenodo.org/record/3660259
NRF2 and chemoprevention
Creators: name: Cheung, Ka Lung
Publisher: name: No Publisher Supplied
Year: 2011

description: Prevention is better than cure. The carcinogenesis could take as long as 20 to 30 years to develop from initiated cells to malignant tumor, therefore providing us various opportunities to prevent the appearance of tumors with the use of chemopreventive compounds in the early stage. Chemoprevention becomes an increasing important concept and has led to the intense research about the mechanisms of actions of various chemopreventive compounds. They can be generally classified into blocking agents and suppressing agents. The chemopreventive compounds usually prevent or slow progression of cancer by maintaining a low oxidative stress and inflammatory environment in cells. This is brought about by the activation of Nrf2, the key protein being investigated in our lab. In this dissertation, I will be discussing the use of compounds as suppressing agents and blocking agents, how compounds activates Nrf2 signaling, how novel Nrf2 interaction partner IQGAP1 mediates Nrf2-Keap1 signaling axis, how expression level of Nrf2 could be regulated epigenetically, apart from the well-known post-translational control by Keap1-Ubiquitinase-Protesome axis and finally how loss of Nrf2 could enhance intestinal tumorigenesis in Apc(min/+) mice.
Effect of estrogen on ETS-induced glyco-oxidation
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Both diabetes and environmental tobacco smoke (ETS) are very strongly associated with arterial disease but very little is known about how these factors contribute to increased disease development. A common link between these two diverse risk factors is that each increase a modification of the arterial wall that is clearly associated with arterial disease. This modification occurs through a process termed glyco-oxidation. Glyco-oxidation increases accumulation of low-density lipoprotein (LDL) in the artery wall and is positively correlated with arterial disease in many diverse populations. While estrogen is widely believed to protect against arterial disease, its mechanism of action is also poorly defined.

 The goal of this proposal is to examine the effect of estrogen on LDL accumulation in diabetic and ETS exposed animals and to examine the effect of estrogen on glyco-oxidation of collagen (a major component of the artery wall) in vitro. We hypothesize that estrogen will decrease LDL accumulation in diabetic animals but be less effective for ETS exposed animals. To test this hypothesis, we will examine the ability of estrogen to decrease glyco-oxidative modification of collagen in vitro. Such in vitro studies can provide information concerning how estrogen may act to decrease arterial modifications that can contribute to arterial disease. We will also examine the effect of estrogen on LDL accumulation caused by ETS exposure and/or diabetes in vivo.

 Information obtained from this study could potentially have a major positive impact on the understanding of how cardiovascular disease develops as a consequence of ETS exposure and diabetes. Additionally, insight into the role of estrogen in preventing arterial disease can be obtained.
Structural analyses of chaperone-substrate interactions inType III secretion systems
Creators: name: Chen, Li
Publisher: name: No Publisher Supplied
Year: 2011

description: The type III secretion system (TTSS) is used by many Gram-negative bacteria to inject virulence proteins across lipid membranes directly into the cytoplasm of eukaryotic host cells. Chaperones are important components of TTS systems wherein they assistwith the assembly and operation of the entire machinery. Generally, the absence of thechaperone results in rapid degradation, aggregation or reduced secretion of its cognate substrates. CesAB has been identified as the chaperone of the translocator EspA in one of the best characterized type III translocon, the enteropathogenic Escherichia coli (EPEC).CesAB maintains the stability of EspA in bacterial cytoplasm by forming stable complex with it. CesAB exists as a homodimer in solution and it undergoes a subunit exchange mechanism to bind to EspA. Our biophysical data have shown that CesAB is a partially folded homodimer in solution. The solution structure of CesAB homodimer was determined by nuclearmagnetic resonance (NMR) spectroscopy. Multidimensional heteronuclear NMRexperiments in combination with other biophysical techniques were used to accomplishstructure determination. Structural and dynamic NMR studies reveal that CesAB exists as a loosely packed, conformationally dynamic homodimer in solution, properties that set it apart from other chaperones. We have characterized the binding of chaperone CesAB to the substrate EspA, a process required for bacterial pathogenicity. The structure of CesAB homodimer provides atomic details of the subunit exchange mechanism to interact with EspA. CesAB adoptsan autoinhibited conformation to prevent self-aggregation and it is rapidly activated forEspA binding by transiently exposing part of the binding site in a mechanism facilitated by packing defects at its homodimeric coiled-coil subunit interface. EspA uses structural mimicry to offset the “weak spots” in CesAB and induce folding of both proteins into thestable heterodimeric complex. Our results present a novel regulatory mechanism in protein-protein interactions mediated by finely-tuned structural instability coupled with molecular mimicry. We show that this mechanism is shared by other chaperone-substrate systems.
Dysoxylum pachyrhache Merr.
Creators: name: Holzmeyer, Laura
name: Hauenschild, Frank
name: Mabberley, David J.
name: Muellner-Riehl, Alexandra N.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Sapindales
Meliaceae
Dysoxylum
Dysoxylum pachyrhache

description: 15. Dysoxylum pachyrhache Merr. in Univ. Calif. Publ. Bot. 15: 120. 1929
– Holotype: Malaysia, Sabah, Tawau, Elmer 21692 (UC No. 290195 [image!]).
Distribution. – Borneo.
Note. – See also Mabberley (2007: 171).
description: Published as part of Holzmeyer, Laura, Hauenschild, Frank, Mabberley, David J. & Muellner-Riehl, Alexandra N., 2021, Confirmed polyphyly, generic recircumscription and typification of Dysoxylum (Meliaceae), with revised disposition of currently accepted species, pp. 1248-1272 in TAXON 70 (6) on page 1263, DOI: 10.1002/tax.12591, http://zenodo.org/record/14047415