cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Hydrogen bonding and proton exchange in trifluoroacetic acid-quinoline and methanolorthochlorophenol mixtures by nuclear magnetic resonance spectroscopy.
Creators: name: Krakower, Earl
Publisher: name: University of British Columbia
Year: 2011

description: High resolution nuclear magnetic resonance is used to investigate proton exchange in two hydrogen bonded systems. The change of the chemical shift of the acid proton with concentration in mixtures of trifluoroacetic acid and quinoline have been used to indicate the formation of a strongly hydrogen bonded ion pair in the pure acid-base system and in acetonitrile as solvent. Spectra at -18°C show resolved peaks for the ≽NH⁺ and -COOH protons confirming the nature of the exchange process. The kinetic processes involved in the exchange are discussed but the experimental difficulty in carrying out a low temperature (0 to -60°C) study of an equimolar mixture of the two components prevents any detailed investigation of the rate processes. The chemical shifts measured for the acid and hetero-ring protons are averages for the various environments so that charge density changes on protonation of a basic species are not proportional to the observed chemical shift changes. Intermolecular hydrogen bonding and proton transfer rates between methanol and orthochlorophenol have been experimentally investigated in the slow exchange approximation for the modified Bloch Equations (0°C to -41.1°C). Interpolations of the results to the fast exchange limit are consistent with experimental line widths in this region. The activation energy obtained for the first order kinetics is 4.58 Kcal mole⁻¹. It is considered that the intramolecular hydrogen bond in orthochlorophenol does not impede the proton exchange process in the two component system. Variations in the line width of the exchange averaged -OH resonance signal are used to indicate the effect of small quantities of water added to the methanol-orthochlorophenol mixtures.
Modelling the light-curves of objects tidally disrupted by a black hole
Creators: name: Kostic, U.
name: Gomboc, A.
name: Cadez, A.
name: Calvani, M.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Tidal disruption by massive black holes is a phenomenon, during which a large part of gravitational energy can be released on a very short time-scale. The time-scales and energies involved during X-ray and IR flares observed in Galactic centre suggest that they may be related to tidal disruption events. Furthermore, aftermath of a tidal disruption of a star by super-massive black hole has been observed in some galaxies, e.g. RX J1242.6-1119A. All these discoveries increased the demand for tools for tidal disruption study in curved space-time. Here we summarise our study of general relativistic effects on tidal deformation of stars and compact objects.
description: 2 pages, to appear in the proceedings of the JENAM 2008, Symposium 7: "Grand Challenges in Computational Astrophysics"
Efficacy and safety of dupilumab in chronic rhinosinusitis with nasal polyps: a systematic review and meta-analysis
Creators: name: Sim, Linger
name: Shukri, Norasnieda Md
name: Yaacob, Najib Majdi
name: Periasamy, Chenthilnathan
name: Cornelia, Musat Gabriela
name: Abdullah, Baharudin
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Space Science
subject: Medicine
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Chronic rhinosinusitis with nasal polyps (CRSwNP) primarily displays type 2 inflammation, characterized by the activation of interleukin (IL)-4, IL-5, and IL-13 in the pathway. The purpose of this study is to determine the efficacy and safety of dupilumab (an IL-4 antagonist) in treating CRSwNP. A detailed search was performed in PubMed, Embase and the Cochrane Library databases. All published English-language randomized controlled trials (RCTs) that employed dupilumab to treat CRSwNP in adult patients (≥18 years old) were considered. Three RCTs and 25 studies with 784 individuals were included. The use of dupilumab revealed improvement in polyp size (MD −1.80; 95% CI −2.25 to −1.36), Lund-Mackay score (MD −7.01, 95% CI −9.64 to −4.38), congestion (MD −0.86, 95% CI −0.99 to −0.73), smell (MD 10.83, 95% CI 9.59 to 12.08) and health-related quality of life (MD −19.61, 95% CI −22.53 to −16.69). Systemic corticosteroid use (RR 0.28, 95% CI 0.20–0.39) and revision surgery (RR 0.17, 95% CI 0.05–0.52) were reduced. Serious adverse events were reduced in dupilumab group (RR 0.47; 95% CI 0.29 to 0.76) with no change in risk of adverse events (RR 0.98, 95% CI 0.87 to 1.11). Dupilumab is effective with minimal adverse events. www.crd.york.ac.uk/prospero identifier is CRD42023413004.
title: A Critical Review of Research on Formative Assessments: The Limited Scientific Evidence of the Impact of Formative Assessments in Education
Creators: name: Dunn, Karee E.
name: Mulvenon, Sean W.
Publisher: name: University of Massachusetts Amherst
Year: 2009

description: The existence of a plethora of empirical evidence documenting the improvement of educational outcomes through the use of formative assessment is conventional wisdom within education. In reality, a limited body of scientifically based empirical evidence exists to support that formative assessment directly contributes to positive educational outcomes. The use of formative assessments, or other diagnostic efforts within classrooms, provides information that should help facilitate improved pedagogical practices and instructional outcomes. However, a review of the formative assessment literature revealed that there is no agreed upon lexicon with regard to formative assessment and suspect methodological approaches in the efforts to demonstrate positive effects that could be attributed to formative assessments. Thus, the purpose of this article was two-fold. First, the authors set out to clarify the terminology related to formative assessment and its usage. Finally, the article provides a critical analysis of the seminal literature on formative assessment, beginning with Black and Wiliam (1998), and extending through current published materials. Accessed 61,395 times on https://pareonline.net from March 20, 2009 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right.
title: Multiple Constructs and the Effects of Accommodations on Standardized Test Scores for Students with Disabilities
Creators: name: Cawthon, Stephanie W.
name: Ho, Eching
name: Patel, Puja G.
name: Potvin, Deborah C.
name: Trundt, Katherine M.
Publisher: name: University of Massachusetts Amherst
Year: 2009

description: Students with disabilities frequently use accommodations to participate in large-scale, standardized assessments. Accommodations can include changes to the administration of the test, such as extended time, changes to the test items, such as read aloud, or changes to the student's response, such as the use of a scribe. Some accommodations or modifications risk changing the difficulty of the test items or decreasing the validity of how test scores are interpreted. Questions regarding the validity of accommodated tests are heightened when scores are used in high-stakes decisions such as grade promotion, graduation, teacher merit pay, or other accountability initiatives. The purpose of this article is to review existing literature on multiple constructs that affect validity of interpretations of accommodated assessment scores. Research on assessment accommodations continues to grow but offers few conclusive findings on whether they facilitate fair and accurate measurement of student knowledge and skill. The validity of an accommodated score appears to vary depending on several factors such as student characteristics, test characteristics, and the accommodations themselves. A multiple construct approach may facilitate more accurate evaluations of the effects of accommodated test scores Accessed 12,923 times on https://pareonline.net from October 19, 2009 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right.
Quantum Ratchet Effect for Vortices
Creators: name: Majer, J. B.
name: Peguiron, J.
name: Grifoni, Milena
name: Tusveld, M.
name: Mooij, J. E.
Publisher: name: Universität Regensburg
Year: 2003
Subjects: subject: 530 Physik

description: We have measured a quantum ratchet effect for vortices moving in a quasi-one-dimensional Josephson junction array. In this solid-state device the shape of the vortex potential energy, and consequently the band structure, can be accurately designed. This band structure determines the presence or absence of the quantum ratchet effect. In particular, asymmetric structures possessing only one band below the barrier do not exhibit current rectification at low temperatures and bias currents. The quantum nature of transport is also revealed in a universal/nonuniversal power-law dependence of the measured voltage-current characteristics for samples without/with rectification.
title: A comparison of two approaches to correction of restriction of range in correlation analysis
Creators: name: Wiberg, Marie
name: Sundström, Anna
Publisher: name: University of Massachusetts Amherst
Year: 2009

description: A common problem in predictive validity studies in the educational and psychological fields, e.g. in educational and employment selection, is restriction in range of the predictor variables. There are several methods for correcting correlations for restriction of range. The aim of this paper was to examine the usefulness of two approaches to correcting for range restriction; Thorndike's case 2 correction and ML estimates obtained from the EM algorithm, by comparing the corrected correlations with the correlation from an unrestricted sample. The unrestricted sample consisted of examinees who took the practical Swedish driving-license test regardless of their result on the theory test. Examinees that passed the theory test and took the practical test were regarded as a restricted sample. The result provided empirical support for the appropriateness of Thorndike's case 2 correction method. Although using the EM algorithm yielded a good estimate of the correlation in the unrestricted sample, further studies are needed on this topic Accessed 26,598 times on https://pareonline.net from March 18, 2009 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right.
gamma-ray emission from LS I +61 303: The impact of basic system uncertainties
Creators: name: Sierpowska-Bartosik, Agnieszka
name: Torres, Diego F.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: LS I +61 303 has been recently detected as a periodic gamma-ray source by the Major Atmospheric Imaging Cerenkov (MAGIC) telescope. A distinctive orbital correlation of the $γ$-ray emission was found. This work shows that the range of uncertainties yet at hand in the orbital elements of the binary system LSI as well as in the possible assumptions on the stellar wind of the optical companion play a non-negligible role in the computation of opacities to high energy processes leading to $γ$-ray predictions. The geometry influence on the propagation and escape of $γ$-ray photons is explored. With this study at hand, we analyse the results of a pulsar wind zone model for the production of gamma-rays and compare it with recent MAGIC observations.
description: 27 pages, 12 figures. References corrected. Journal Ref. with publication details added
Adverse reactions associated with SSRIs and PD-1/PD-L1 inhibitors: a disproportionality analysis of the FDA Adverse Event Reporting System
Creators: name: Dong, Jiaqi
name: Liu, Mingyue
name: Li, Suning
name: Zhang, Siqi
name: Fu, Pengbin
name: Liu, Mengya
name: Jin, Shasha
name: Fan, Chunliang
name: Fang, Mingzhu
name: Wu, Liang
name: Li, Zhe
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health

description: Selective serotonin reuptake inhibitors (SSRIs) are the primary choice for antidepressant therapy in cancer patients with depression. Programmed death-1 and programmed cell death-ligand 1 (PD-1/PD-L1) play a critical role in immune checkpoint inhibitors. To date, there have been no studies reporting adverse events (AEs) associated with the real-world use of PD-1/PD-L1 inhibitors-SSRIs combination. This study included a comprehensive evaluation of AE cases covered PD-1/PD-L1 inhibitors-SSRIs combination (first quarter of 2004 to second quarter of 2024) using the FDA Adverse Event Reporting System (FAERS) database, and compared with the use of PD-1/PD-L1 inhibitors or SSRIs alone. By extracting a total of 807 reports of related AEs, the combination therapy was associated with a distinct AE profile characterized by an increased incidence of immune-related and systemic disorders, as well as a higher signal for adverse pregnancy and perinatal outcomes. This study represents the largest report to date on PD-1/PD-L1 inhibitors-SSRIs -related AEs, providing valuable insights into the potential side effects of SSRIs for cancer patients with depression. Clinicians should exercise caution when prescribing SSRIs alongside PD-1/PD-L1 inhibitors, particularly in vulnerable populations such as pregnant women and those with significant comorbidities.
title: Understanding and Using Factor Scores: Considerations for the Applied Researcher
Creators: name: DiStefano, Christine
name:  Zhu, Min
name: Mîndrilã, Diana
Publisher: name: University of Massachusetts Amherst
Year: 2009

description: Following an exploratory factor analysis, factor scores may be computed and used in subsequent analyses. Factor scores are composite variables which provide information about an individual's placement on the factor(s). This article discusses popular methods to create factor scores under two different classes: refined and non-refined. Strengths and considerations of the various methods, and for using factor scores in general, are discussed. Accessed 118,299 times on https://pareonline.net from October 26, 2009 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right.
Generating abelian groups by addition only
Creators: name: Klopsch, Benjamin
name: Lev, Vsevolod F.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Group Theory (math.GR)
subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 20K01, 20F05

description: We define the positive diameter of a finite group $G$ with respect to a generating set $A\subset G$ to be the smallest non-negative integer $n$ such that every element of $G$ can be written as a product of at most $n$ elements of $A$. This invariant, which we denote by $\diam_A^+(G)$, can be interpreted as the diameter of the Cayley digraph induced by $A$ on $G$. In this paper we study the positive diameters of a finite abelian group $G$ with respect to its various generating sets $A$. More specifically, we determine the maximum possible value of $\diam_A^+(G)$ and classify all generating sets for which this maximum value is attained. Also, we determine the maximum possible cardinality of $A$ subject to the condition that $\diam_A^+(G)$ is "not too small". Conceptually, the problems studied are closely related to our earlier work and the results obtained shed a new light on the subject. Our original motivation came from connections with caps, sum-free sets, and quasi-perfect codes.
Using Statistical Moment Invariants and Entropy in Image Retrieval
Creators: name: Amr, Ismail I.
name: Amin, Mohamed
name: Kafrawy, Passent El
name: Sauber, Amr M.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Multimedia (cs.MM)
subject: Information Retrieval (cs.IR)
subject: FOS: Computer and information sciences

description: Although content-based image retrieval (CBIR) is not a new subject, it keeps attracting more and more attention, as the amount of images grow tremendously due to internet, inexpensive hardware and automation of image acquisition. One of the applications of CBIR is fetching images from a database. This paper presents a new method for automatic image retrieval using moment invariants and image entropy, our technique could be used to find semi or perfect matches based on query by example manner, experimental results demonstrate that the purposed technique is scalable and efficient.
description: IEEE format, International Journal of Computer Science and Information Security, IJCSIS January 2010, ISSN 1947 5500, http://sites.google.com/site/ijcsis/
title: Reporting Subscores from College Admission Tests
Creators: name: Lyrén, Per-Erik
Publisher: name: University of Massachusetts Amherst
Year: 2009

description: The added value of reporting subscores on a college admission test (SweSAT) was examined in this study. Using a CTT-derived objective method for determining the value of reporting subscores, it was concluded that there is added value in reporting section scores (Verbal/Quantitative) as well as subtest scores. These results differ from a study of the SAT I and a study of a basic skills test and thus highlight the need for practitioners and researchers to gather empirical evidence to support the reporting of subscores. The cause of the disparate results seems to be related to differences in the composition of the tests rather than differences in the composition of the examinee groups. Accessed 9,127 times on https://pareonline.net from March 17, 2009 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right.
title: Using Power Tables to Compute Statistical Power in Multilevel Experimental Designs
Creators: name: Konstantopoulos, Spyros
Publisher: name: University of Massachusetts Amherst
Year: 2009

description: Power computations for one-level experimental designs that assume simple random samples are greatly facilitated by power tables such as those presented in Cohen’s book about statistical power analysis. However, in education and the social sciences experimental designs have naturally nested structures and multilevel models are needed to compute the power of the test of the treatment effect correctly. Such power computations may require some programming and special routines of statistical software. Alternatively, one can use the typical power tables to compute power in nested designs. This paper provides simple formulae that define expected effect sizes and sample sizes needed to compute power in nested designs using the typical power tables. Simple examples are presented to demonstrate the usefulness of the formulae. Accessed 18,608 times on https://pareonline.net from May 20, 2009 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right.
title: Diagnostic Assessments in Mathematics to Support Instructional Decision Making
Creators: name: Ketterlin-Geller, Leanne R.
name: Yovanoff, Paul
Publisher: name: University of Massachusetts Amherst
Year: 2009

description: Diagnosis is an integral part of instructional decision-making. As the bridge between identification of students who may be at-risk for failure and delivery of carefully designed supplemental interventions, diagnosis provides valuable information about student's persistent misconceptions in the targeted domain. In this paper, we discuss current approaches to diagnosis in mathematics and highlight the strengths and limitations of each approach for making instructional decisions. We point to cognitive diagnostic assessments as an emerging solution for providing detailed and precise information about student's thinking that is needed to provide appropriate educational opportunities for students struggling in mathematics. Accessed 41,983 times on https://pareonline.net from October 12, 2009 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right.
title: Combining Dual Scaling with Semi-Structured Interviews to Interpret Rating Differences
Creators: name: Childs, Ruth A.
name: Ram, Anita
name: Xu, Yunmei
Publisher: name: University of Massachusetts Amherst
Year: 2009

description: Dual scaling, a variation of multidimensional scaling, can reveal the dimensions underlying scores, such as rater's judgments. This study illustrates the use of a dual scaling analysis with semi-structured interviews of raters to investigate the differences among the raters as captured by the dimensions. Thirty applications to a one-year post-Bachelor's degree teacher education program were rated by nine teacher educators. Eight of the raters were subsequently interviewed about how they rated the responses. A three-dimensional model was found to explain most of the variance in the ratings for two of the questions and a two-dimensional model was most interpretable for the third question. The interviews suggested that the dimensions reflected, in addition to differences in rater's stringency, differences in their beliefs about their roles as raters and about the types of insights that were required of applicants. Accessed 9,371 times on https://pareonline.net from May 26, 2009 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right.
title: The power of outliers (and why researchers should ALWAYS check for them)
Creators: name: Osborne, Jason W.
name: Overbay, Amy
Publisher: name: University of Massachusetts Amherst
Year: 2004

description: There has been much debate in the literature regarding what to do with extreme or influential data points. The goal of this paper is to summarize the various potential causes of extreme scores in a data set (e.g., data recording or entry errors, motivated mis-reporting, sampling errors, and legitimate sampling), how to detect them, and whether they should be removed or not.  Another goal of this paper was to explore how significantly a small proportion of outliers can affect even simple analyses.  The examples show a strong beneficial effect of removal of extreme scores.  Accuracy tended to increase significantly and substantially, and errors of inference tended to drop significantly and substantially once extreme scores were removed
A study of molecular motion in potassium caproate, caprylate, and caprate and lithium stearate by proton magnetic resonance.
Creators: name: Janzen, Wayne Roger
Publisher: name: University of British Columbia
Year: 2011

description: Proton magnetic resonance has been measured in the temperature range -196° to 295°C for potassium caprylate, from -196° to 230°C for lithium stearate, and at -196° and 27°C for potassium caproate. Theoretical second moments for potassium caproate, caprylate and caprate at -196°C were computed using various molecular parameters and were compared with experimental values. Unfortunately the theoretical values were sufficiently alike for any one soap so that it could not be decided which of the parameters were applicable. The results do show, however, that the end methyl group rotates in potassium caproate at -196°C and probably does so in potassium caprylate and caprate. A sharp decrease in line width and second moment takes place in potassium caprylate between 50° and 55°C and between 283° and 286°C. The first transition corresponds to a known crystal phase change at 55°C. The second moment results suggest that some torsional oscillation about the longitudinal axes of the hydrocarbon chain portion of the potassium caprylate molecules takes place below 50° C. Above 55°C torsional oscillation of large amplitude or possibly even rotation of the hydrocarbon chain occurs. The transition between 283° and 286°C corresponds to onset of motion in the hydrocarbon chain restricted only by continued ordering of the polar end groups in the ionic layer of the soap. The proton magnetic resonance results in lithium stearate indicate transitions at 115°, 171+°, and 225°C. These pmr transitions correspond to known phase transitions. The second moment results suggest that the methyl group of the hydrocarbon chain in lithium stearate begins to rotate between-183° and -136°C. The second moment above 115°C is approximately equivalent to that estimated for rotation of the hydrocarbon chain about its long axis. Above 171°C very extensive motion of the chains occurs, although they are still held in position by the ionic layer. The ionic layer begins to break up in the region 215° to 218°C, with the compound becoming an isotropic liquid at about 225°C.
Efficacy and safety of dupilumab in chronic rhinosinusitis with nasal polyps: A systematic review and meta-analysis
Creators: name: Sim, Linger
name: Shukri, Norasnieda Md
name: Yaacob, Najib Majdi
name: Periasamy, Chenthilnathan
name: Cornelia, Musat Gabriela
name: Abdullah, Baharudin
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Space Science
subject: Medicine
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Chronic rhinosinusitis with nasal polyps (CRSwNP) primarily displays type 2 inflammation, characterized by the activation of interleukin (IL)-4, IL-5, and IL-13 in the pathway. The purpose of this study is to determine the efficacy and safety of dupilumab (an IL-4 antagonist) in treating CRSwNP. A detailed search was performed in PubMed, Embase and the Cochrane Library databases. All published English-language randomized controlled trials (RCTs) that employed dupilumab to treat CRSwNP in adult patients (≥18 years old) were considered. Three RCTs and 25 studies with 784 individuals were included. The use of dupilumab revealed improvement in polyp size (MD -1.80; 95% CI -2.25 to -1.36), Lund-Mackay score (MD -7.01, 95% CI -9.64 to -4.38), congestion (MD -0.86, 95% CI -0.99 to -0.73), smell (MD 10.83, 95% CI 9.59 to 12.08) and health-related quality of life (MD -19.61, 95% CI -22.53 to -16.69). Systemic corticosteroid use (RR 0.28, 95% CI 0.20-0.39) and revision surgery (RR 0.17, 95% CI 0.05-0.52) were reduced. Serious adverse events were reduced in dupilumab group (RR 0.47; 95% CI 0.29 to 0.76) with no change in risk of adverse events (RR 0.98, 95% CI 0.87 to 1.11). Dupilumab is effective with minimal adverse events. www.crd.york.ac.uk/prospero identifier is CRD42023413004.
title: Computers, The Internet, and Cheating Among Secondary School Students: Some Implications for Educators
Creators: name: Conradson, Stacey
name:  Hernández-Ramos, Pedro
Publisher: name: University of Massachusetts Amherst
Year: 2004

description: This article investigates in greater depth one particular aspect of cheating within secondary education and some implications for measuring academic achievement. More specifically, it examines how secondary students exploit the Internet for plagiarizing schoolwork, and looks at how a traditional method of educational assessment, namely paper-based report and essay writing, has been impacted by the growth of Internet usage and the proliferation of computer skills among secondary school students. One of the conclusions is that students’ technology fluency is forcing educators to revisit conventional assessment methods. Different options for combating Internet plagiarism are presented, and some software tools as well as non-technology solutions are evaluated in light of the problems brought about by “cyberplagiarism.” Accessed 102,733 times on https://pareonline.net from March 30, 2000 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right.
Long-Lived Slepton in the Coannihilation Region and Measurement of Lepton Flavour Violation at LHC
Creators: name: Kaneko, S.
name: Sato, J.
name: Shimomura, T.
name: Vives, O.
name: Yamanaka, M.
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: When the mass difference between the lightest slepton and the lightest neutralino is smaller than the tau mass, the lifetime of the lightest slepton in the constrained Minimal Supersymmetric Standard Model (MSSM) increases in many orders of magnitude with respect to typical lifetimes of other supersymmetric particles. In a general MSSM, the lifetime of the lightest slepton is inversely proportional to the square of the intergenerational mixing in the slepton mass matrices. Such a long-lived slepton would produce a distinctive signature at LHC and a measurement of its lifetime would be relatively simple. Therefore, the long-lived slepton scenario offers an excellent opportunity to study lepton flavour violation at ATLAS and CMS detectors in the LHC and an improvement of the leptonic mass insertion bounds by more than five orders of magnitude would be possible.
description: 10 pages, 2 figures, 2 tables. To appear in the proceedings of Symposium on Prospects in the Physics of Discrete Symmetries (Discrete'08), Valencia, Spain, 11-16 December 2008
Adverse reactions associated with SSRIs and PD-1/PD-L1 inhibitors: a disproportionality analysis of the FDA adverse event reporting system
Creators: name: Dong, Jiaqi
name: Liu, Mingyue
name: Li, Suning
name: Zhang, Siqi
name: Fu, Pengbin
name: Liu, Mengya
name: Jin, Shasha
name: Fan, Chunliang
name: Fang, Mingzhu
name: Wu, Liang
name: Li, Zhe
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health

description: Selective serotonin reuptake inhibitors (SSRIs) are the primary choice for antidepressant therapy in cancer patients with depression. Programmed death-1 and programmed cell death-ligand 1 (PD-1/PD-L1) play a critical role in immune checkpoint inhibitors. To date, there have been no studies reporting adverse events (AEs) associated with the real-world use of PD-1/PD-L1 inhibitors-SSRIs combination. This study included a comprehensive evaluation of AE cases covered PD-1/PD-L1 inhibitors-SSRIs combination (1st quarter of 2004 to 2nd quarter of 2024) using the FDA Adverse Event Reporting System (FAERS) database, and compared with the use of PD-1/PD-L1 inhibitors or SSRIs alone. By extracting a total of 807 reports of related AEs, the combination therapy was associated with a distinct AE profile characterized by an increased incidence of immune-related and systemic disorders, as well as a higher signal for adverse pregnancy and perinatal outcomes. This study represents the largest report to date on PD-1/PD-L1 inhibitors-SSRIs -related AEs, providing valuable insights into the potential side effects of SSRIs for cancer patients with depression. clinicians should exercise caution when prescribing SSRIs alongside PD-1/PD-L1 inhibitors, particularly in vulnerable populations such as pregnant women and those with significant comorbidities.
Mining and analysis of adverse events associated with aducanumab: a real-world study using FDA Adverse Event Reporting System database
Creators: name: Wu, Shuangshuang
name: Qi, Yiming
name: Jiang, Cheng
name: Zheng, Junxian
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Mental Health

description: Aducanumab, a monoclonal antibody, received approval for the treatment of Alzheimer’s disease in 2021. However, it remains controversial over the security of this drug. In this study, aducanumab-related adverse events (AEs) were evaluated through data mining based on the FDA Adverse Event Reporting System (FAERS) database. The AE reports induced by aducanumab as the primary suspected drug were extracted from the FAERS database. The clinical characteristics of aducanumab-associated reports were analyzed. The potential new AE signals of aducanumab were explored using four disproportionality analysis methods. Furthermore, the difference in aducanumab-associated AE signals was investigated concerning sex, age, weight, dose, onset time, and continent. In total, 328 reports and 793 AEs associated with aducanumab were identified. Six new AEs were identified. No significant sex and weight difference in aducanumab-related signals was found. Notably, nervous system disorders, especially ‘amyloid related imaging abnormality-edema/effusion’ and ‘amyloid related imaging abnormality-microhaemorrhages and haemosiderin deposits,’ were more frequently to be reported within 121–240 days, particularly in Europe. This study contributes real-world evidence regarding the safety of aducanumab.
Additional file 1 of PD-L1+ macrophages are associated with favorable features in primary mediastinal (thymic) large B-cell lymphoma
Creators: name: Steiner, Raphael E.
name: Parra, Edwin R.
name: Vega, Francisco
name: Feng, Lei
name: Westin, Jason R.
name: Neelapu, Sattva S.
name: Strati, Paolo
name: Green, Michael R.
name: Flowers, Christopher R.
name: Solis, Luisa M.
name: Wistuba, Ignacio I.
name: Ahmed, Sairah
name: Nair, Ranjit
name: Hagemeister, Fredrick B.
name: Noorani, Mansoor
name: Marques-Piubelli, Mario L.
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1: Methods; Figure S1. Representative pictures showing different cell densities of CD30+PD-L1+ cells. A-C) Multiplex immunofluorescence image of a case with low cell density of CD30+, PD-L1+, and CD30+PD-L1+ cells median: 20.46 cells/mm2, respectively. D-E) Multiplex immunofluorescence image of a case with high cell density of CD30+, PD-L1+, and CD30+PD-L1+ cells (median: 604.62 cells/mm2), respectively. Supplementary Table 1.
FULL-POTENTIAL SCATTERED-WAVE CALCULATIONS FOR MOLECULES AND CLUSTERS: FUNDAMENTAL TESTS OF THE METHOD
Creators: name: D. L. FOULIS
name: R. F. PETTIFER
name: C. R. NATOLI
name: M. BENFATTO
Publisher: name: INFN Open Access Repository
Year: 1991

description: We describe the testing of a non-maffin-tin extension to the scattered-wave method (due to Natoli, Benfatto and Doniach [Phys. Rev. A 34, 4682(1986)]) for the calculation of one-electron energy eigenvalues and photoionization cross sections of molecules. For bound states the hydrogen molecular ion is used, and for continuum photoionization an ionized lithium pseudocluster is used, these being excellent tests because the analytic results are also known. Comparison of the results shows that the theory is correct and that the computational approach is feasible.
Safety profile of isocitrate dehydrogenase inhibitors in cancer therapy: a pharmacovigilance study of the FDA Adverse Event Reporting System
Creators: name: Fu, Yiming
name: Lv, Ruxue
name: Li, Ruizhen
name: Li, Wenjie
name: Guo, Zhaoze
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Isocitrate dehydrogenase (IDH) inhibitors hold promise for IDH-mutated cancer patients and demonstrated favorable clinical efficacy. Nonetheless, a comprehensive understanding of the associated toxicities of IDH inhibitors remains notably lacking. This pharmacovigilance analysis utilized the FDA Adverse Event Reporting System (FAERS) database to assess notable adverse events (AEs) attributed to IDH inhibitors (enasidenib and ivosidenib) from January 2018 to December 2023. In the FAERS database, 2,905 enasidenib-associated and 1,289 ivosidenib-related AEs records were identified, respectively. The toxicity profiles of IDH1 and IDH2 inhibitors exhibited notable similarities. The most commonly significant system-organ classes induced by IDH inhibitors encompassed general disorders and administration site conditions, investigations, gastrointestinal disorders, and infections and infestations. The most common AEs included nausea, fatigue, diarrhea, decreased appetite, decreased platelet count, fever, pneumonia, weakness, sepsis, constipation, vomiting, rash, and reduced hemoglobin levels. Notably, temporal analysis of AEs shows enasidenib and ivosidenib have median onset times of 137 and 75 days, with distinct initial peak frequencies. The reversible nature of the toxicities associated with IDH inhibitors underscores their promise as a therapeutic agent with a favorable safety profile.
title: A Standards-Driven, Task-Based Assessment Approach for Teacher Credentialing with Potential for College Accreditation
Creators: name: Judy, R. Wilkerson
name: Lang, William Steve
Publisher: name: University of Massachusetts Amherst
Year: 2004

description: When the Southeast Center for Teaching Quality (2003a) studied what teachers would want to tell policy makers about highly qualified teacher requirements, they summarized their findings in this quote:  “Come to my classroom, and not just for a day.” (p. 2).  What could be a more obvious invitation to improve and expand teacher assessment?  The standardized objective tests and occasional formal observational evaluations being used to measure teacher competence today have been contested for decades as ineffective according to politicians and invalid according to researchers.    While these two long-standing and useful assessment strategies are important components of an overall assessment system, neither – alone or paired – is sufficient to identify and remediate new teacher deficiencies.  This article includes a series of recommendations, organized in steps, for developing an assessment approach that is task-based, standardsdriven, and job-related that would serve as a major component of a comprehensive beginning teacher assessment system.    These recommendations are based on a two-year effort that resulted in Florida’s Alternative Certification Program Assessment System.  This system has now been adopted by about twothirds of the Florida school districts and is beginning to be adopted by colleges of education preparing teachers through the traditional route.  The design takes into account three sets of standards:  the Florida requirements for program approval the NCATE requirements for accreditation, and the Standards of Educational and Psychological Testing (referred to as the Standards; AERA, APA, and NCME, 1999).  These standards define the ultimate purpose of decisions about initial teacher competence:  protecting the public from unqualified practitioners.Accessed 48,073 times on https://pareonline.net from June 08, 2004 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right.
Direct carbonylation of aromatic nitriles using dicabalt octacarbonyl
Creators: name: Gervay, Joseph Edmund
Publisher: name: University of British Columbia
Year: 2011

description: A new method of synthesizing N-substituted phthalimidines is described. When benzonitrile was reacted with carbon monoxide containing about 0.04 volume percent of hydrogen and in the presence of dicobalt octacarbonyl and pyridine in benzene solution at 235° and 3400 p.s.i. pressure the following compounds were produced: N-benzyphthalimidine (8%), N-phenylphthalimidine (3.7%), and benzamide (3.9%). When 40 p.s.i. hydrogen was added under the same reaction conditions, the yield of N-benzylphthalimidine increased (16%). When benzonitrile was subjected to the same reaction conditions using 240 p.s.d. hydrogen and no pyridine, N-benzylphthalimidine (15%) and sym-dibenzylurea (8%) were produced. A study on the mechanism of the ring closure process using deuterium gas revealed, that the ortho- hydrogen of the aromatic ring is not transferred directly to the unsaturated carbon-nitrogen bond in the course of the reaction. When phenylacetonitrile was reacted with carbon monoxide and 350 p.s.i. hydrogen at 250° in the presence of dicobalt octacarbonyl the following compounds were isolated: phenacetyl- β-phenethylamine (30%), di-β-phenylethylamine (23%), di- β-phenylethylurea (3.1%) and phenylacetamide (3%). When m-tolunitrile was reacted under similar reaction conditions with 185 p.s.i. hydrogen at 240°, N-m-xylylurea (9.5%), N,N'-di-m-xylylurea (13.5%), and m-toluamide (11.5%) were produced. Organometallic complexes were also obtained in all the reactions described above. The infrared spectra of all the compounds obtained, and the n.m.r.. spectra of N-benzylphthalimidine and N phenylphthalimidine are described.
High-resolution UVES/VLT spectra of white dwarfs observed for the ESO SN Ia Progenitor Survey. III. DA white dwarfs
Creators: name: Koester, D.
name: Voss, B.
name: Napiwotzki, R.
name: Christlieb, N.
name: Homeier, D.
name: Lisker, T.
name: Reimers, D.
name: Heber, U.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The ESO Supernova Ia Progenitor Survey (SPY) took high-resolution spectra of more than 1000 white dwarfs and pre-white dwarfs. About two thirds of the stars observed are hydrogen-dominated DA white dwarfs. Here we present a catalog and detailed spectroscopic analysis of the DA stars in the SPY. Atmospheric parameters effective temperature and surface gravity are determined for normal DAs. Double-degenerate binaries, DAs with magnetic fields or dM companions, are classified and discussed. The spectra are compared with theoretical model atmospheres using a chi^2 fitting technique. Our final sample contains 615 DAs, which show only hydrogen features in their spectra, although some are double-degenerate binaries. 187 are new detections or classifications. We also find 10 magnetic DAs (4 new) and 46 DA+dM pairs (10 new).
description: accepted by Astronomy and Astrophysics
Disproportionality analysis of adverse events associated with asfotase alfa: a post-marketing study using the FDA Adverse Event Reporting System
Creators: name: Wen, Wang
name: Zhe, Wang
name: Qianxiu, Chen
name: Haixia, Sun
name: Zongchao, Fu
name: Jing, Han
name: Hao, Lv
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Mental Health

description: Asfotase alfa (AA) is an FDA-approved enzyme replacement therapy for hypophosphatasia (HPP). Limited real-world data on its adverse events (AEs) exist. This study evaluates AA-related AEs using the U.S. FDA’s Adverse Event Reporting System (FAERS) database. Reports for AA were extracted from FAERS and analyzed per FDA guidelines. AEs were categorized using MedDRA version 26.1. Disproportionality analysis was conducted using the reporting odds ratio (ROR), proportional reporting ratio (PRR), Bayesian confidence propagation neural network (BCPNN), and empirical Bayes geometric mean (EBGM) algorithms. Time-to-onset (TTO) was calculated, with a Weibull shape parameter test to assess risk over time. Out of 13,702,373 reports, 5,040 AA-related AEs were identified, with 198 significant preferred terms (PTs). Common AEs included injection site reactions and pain, with additional PTs for ear/labyrinth disorders and infections. The median onset for 234 AEs with reported times was 170 days (IQR 18–390 days). No significant differences in AEs were found across gender or age groups. Most AEs align with known data, but newly identified ear/labyrinth disorders and infections require further investigation to enhance AA’s safety profile.
title: What's still wrong with rubrics: Focusing on the consistency of performance criteria across scale levels
Creators: name: Tierney, Robin
name: Simon, Marielle
Publisher: name: University of Massachusetts Amherst
Year: 2004

description: This article examines the guidelines and principles in current educational literature that relate to performance criteria..in scoring rubrics. The focus is on the consistency of the language that is used across the scale levels to describe performance criteria for learning and assessment. Accessed 112,155 times on https://pareonline.net from January 28, 2004 to December 31, 2019. For downloads from January 1, 2020 forward, please click on the PlumX Metrics link to the right.
Warm gas accretion onto the Galaxy
Creators: name: Bland-Hawthorn, J.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present evidence that the accretion of warm gas onto the Galaxy today is at least as important as cold gas accretion. For more than a decade, the source of the bright H-alpha emission (up to 750 mR) along the Magellanic Stream has remained a mystery. We present a hydrodynamical model that explains the known properties of the H-alpha emission and provides new insights on the lifetime of the Stream clouds. The upstream clouds are gradually disrupted due to their interaction with the hot halo gas. The clouds that follow plough into gas ablated from the upstream clouds, leading to shock ionisation at the leading edges of the downstream clouds. Since the following clouds also experience ablation, and weaker H-alpha (100-200 mR) is quite extensive, a disruptive cascade must be operating along much of the Stream. In order to light up much of the Stream as observed, it must have a small angle of attack (~20 deg) to the halo, and this may already find support in new HI observations. Another prediction is that the Balmer ratio will be substantially enhanced due to the slow shock. We find that the clouds are evolving on timescales of 100-200 Myr, such that the Stream must be replenished by the Magellanic Clouds at a fairly constant rate (>0.1 Msun/yr). The ablated material falls onto the Galaxy as a warm drizzle; diffuse ionized gas at 10^4 K is an important constituent of galactic accretion. We consider the stability of HI clouds falling towards the Galactic disk and show that most of these must break down into smaller fragments that become partially ionized. The Galactic halo is expected to have huge numbers of smaller neutral and ionized fragments. When the ionized component is accounted for, the rate of gas accretion is ~0.4 Msun/yr, roughly twice the rate deduced from HI observations alone.
description: 14 pages, 6 figures. "The Galaxy Disk in Cosmological Context," Copenhagen, IAU Symp 254, 241; published version with figures available at http://www.physics.usyd.edu.au/~jbh/share/Bland-Hawthorn-IAU254.pdf