cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
АКУШЕРСКИЕ ОСЛОЖНЕНИЯ ПРИ АНТИФОСФОЛИПИДНОМ СИНДРОМЕ.
Creators: name: Салимова, Мадина
name: Атаева, Ф.Н.
Publisher: name: Zenodo
Year: 2024

description: Данная статья посвящена вопросам антифосфолипидного синдрома,  в которой описаны: этиология, патогенез, диагностика, профилактика и лечение.            Антифосфолипидный синдром (АФС)– аутоиммунное приобретенное тромбофилическое заболевание, связанное с наличием антител, проявляющееся артериальными или венозными тромбозами и неблагоприятным течением беременности. Наличие синдрома осложняет течение беременности, часто бывает причиной гибели плода, прерывания беременности. В основе развития патологии лежит образование иммунной системой антител к фосфолипидам, входящим в структуру клеточных мембран. Антитела атакуют собственные клетки, что и приводит к нарушению в их работе
Oral history interview with David Kellum 1971
Publisher: name: Columbia University
Year: 2019
Subjects: Journalism--Social aspects
Journalism--Political aspects
Journalists
African American press
African American journalists
African Americans--Civil rights

description: In his 1971 interview with Henry La Brie III, Kellum discusses how he began to work at the Chicago Defender. Later, he describes the origins of the Bud Billiken Club, his collaboration with Lucius Harper, the first Bud Billiken Parade and the involvement of the blackface comics behind Amos 'n' Andy. Kellum also outlines the process of rewriting news stories from a "black angle" and his work after leaving the Defender. Kellum discusses his role in bringing black and white children together for the Bud Billiken Parade during a period of racial segregation, as well as his efforts toward civil rights and humanitarian work as a journalist.
On entropic uncertainty relations for measurements of energy and its "complement"
Creators: name: Rastegin, Alexey E.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Heisenberg's uncertainty principle in application to energy and time is a powerful heuristics. This statement plays the important role in foundations of quantum theory and statistical physics. If some state exists for a finite interval of time, then it cannot have a completely definite value of energy. It is well known that the case of energy and time principally differs from more familiar examples of two non-commuting observables. Since quantum theory was originating, many approaches to energy-time uncertainties have been proposed. Entropic way to formulate the uncertainty principle is currently the subject of active researches. Using the Pegg concept of complementarity of the Hamiltonian, we obtain uncertainty relations of the "energy-time" type in terms of the Rényi and Tsallis entropies. Although this concept is somehow restricted in scope, derived relations can be applied to systems typically used in quantum information processing. Both the state-dependent and state-independent formulations are of interest. Some of the derived state-independent bounds are similar to the results obtained within a more general approach on the basis of sandwiched relative entropies. The developed method allows us to address the case of detection inefficiencies.
description: 10 pages, one figure. Minor corrections in v3. Except for the style, it matches the journal version
The Painleve Property, W Algebras and Toda Field Theories associated with Hyperbolic Kac-Moody Algebras
Creators: name: Gebert, Reinhold W.
name: Inami, Takeo
name: Mizoguchi, Shun'ya
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We show that the Painlevé test is useful not only for probing (non-)integrability but also for finding the values of spins of conserved currents (W currents) in Toda field theories (TFTs). In the case of the TFTs based on simple Lie algebras the locations of resonances are shown to give precisely the spins of conserved W currents. We apply this test to TFTs based on strictly hyperbolic Kac-Moody algebras and show that there exist no resonances other than that at n=2, which corresponds to the energy-momentum tensor, indicating their non-integrability. We also check by direct calculation that there are no spin-3 nor -4 conserved currents for all the hyperbolic TFTs in agreement with the result of our Painlevé analysis.
description: 27 pages, latex, a uuencoded file for a table available
Consistent off-shell $πN N$ vertex and nucleon self-energy
Creators: name: Kondratyuk, S.
name: Scholten, O.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We present a consistent calculation of half-off-shell form factors in the pion-nucleon vertex and the nucleon self-energy. Numerical results are presented. Near the on-shell point the pion-nucleon vertex is dominated by the pseudovector coupling, while at large nucleon invariant masses we find a sizable pseudoscalar admixture.
description: 23 pages, 7 figures, REVTeX, submitted to Phys. Rev. C, replaced with corrected version
title: Materielle Kultur? Fragestellungen, Entwicklungen, Potenziale
Creators: name: Hahn, Hans Peter
Publisher: name: Institut für Realienkunde des Mittelalters und der frühen Neuzeit
Year: 2019
Subjects: Wissenschaftsgeschichte
Materielle Kultur
material culture
history of science
History

description: Obwohl „materielle Kultur“ ein eher schwach konturiertes Theoriekonzept darstellt und die Relevanz des Materiellen bis heute kontrovers bewertet wird, ist in den letzten fünf Jahrzehnten das Interesse an der Erforschung materieller Kultur deutlich angestiegen. Als „ein Projekt in der Geschichte der Kulturwissenschaften“, das Züge eines travelling concepts trägt, ist materielle Kultur ein Impulsgeber für konzeptuelle und methodologische Innovationen. Zudem vermag sie neue empirische Felder zu erschließen und hat das Potenzial, grundlegende epistemische Probleme wie jenes der Alterität zu überwinden. Der Beitrag skizziert richtungsweisende Entwicklungen der vergangenen Dekaden auf diesem Gebiet und zeigt deren innovative Potenziale an drei konkreten Beispielen: der symmetrischen Anthropologie Bruno Latours, der materialorientierten Herangehensweise Tim Ingolds und dem konsumtheoretischen Ansatz Daniel Millers. During the past fifty years there was an ever increasing interest in material culture studies, even though „material culture“ is a rather weak theoretical concept and its relevance is being debated. However, as “a project in the history of Cultural Studies” which bears characteristics of a “travelling concept”, material culture has sparked an innovation in theories and methods. Moreover, it is able to open up new empirical fields and to overcome basic epistemic problems such as alterity. This review article gives an outline of significant developments in the field of material culture studies within the past decades. The focus lies on the innovative potentials of different methodological approaches, pointing out three examples: the non-anthropocentric model of Bruno Latour, the material-centred perspective of Tim Ingold, and the consumer-oriented concept of Daniel Miller.
description: MEMO Medieval and Early Modern Material Culture Online; Volume 2019 (5); Seitenzahl: x; ISSN: 2523-2932
MAP593.pdf
Creators: name: Coffey, Grant
Publisher: name: Crow Canyon Archaeological Center
Year: 2019
Subjects: Southwestern United States
Terminal Pueblo III
Ancestral Pueblo
Funerary and Burial Structures or Features
Non-Domestic Structures
Domestic Structure or Architectural Complex
Pollen
Ceramic
Chipped Stone
Dating Sample
Fauna
Ground Stone
Human Remains
Macrobotanical
Mineral
Architectural Documentation
Archaeological Overview
Site Evaluation / Testing

description: add description
Affine stochastic equation with triangular matrices
Creators: name: Damek, Ewa
name: Zienkiewicz, Jacek
Publisher: name: arXiv
Year: 2018
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: We study solution X of the stochastic equation X = AX +B, where A is a random matrix and B,X are random vectors, the law of (A,B) is given and X is independent of (A,B). The equation is meant in law, the matrix A is 2x2 upper triangular, A_{11}=A_{22}>0, A_{12} is real. A sharp asymptotics of the tail of X =(X _1,X_2) is obtained. We show that under "so called" Kesten-Goldie conditions P (X_2>t)\sim t^{-a} and P (X_1>t )\sim t^{-a}(\log t)^b, where b =a or a\2.
Oral history interview with David Margolis 1994
Publisher: name: Columbia University
Year: 2019
Subjects: Businessmen

description: Early childhood; College of City of New York, B.A., 1950, M.B.A., 1952; employment with Colt Industries Inc., 1959-; Edward I. Koch [Koch]: first meeting, close friendship with; fiscal advisor to Koch's first mayoral administration: Koch's responses to NYC fiscal crisis, Westway project, relationship with Transit Worker's Union [TWA], 1980 TWA strike; African-American leadership of Koch administration with media; assessment of Koch's administration's strengths and weaknesses.
MAP595.pdf
Creators: name: Coffey, Grant
Publisher: name: Crow Canyon Archaeological Center
Year: 2019
Subjects: Southwestern United States
Terminal Pueblo III
Ancestral Pueblo
Funerary and Burial Structures or Features
Non-Domestic Structures
Domestic Structure or Architectural Complex
Pollen
Ceramic
Chipped Stone
Dating Sample
Fauna
Ground Stone
Human Remains
Macrobotanical
Mineral
Architectural Documentation
Archaeological Overview
Site Evaluation / Testing

description: add description
Modulation of Sensory Nerve Function and the Cough Reflex
Creators: name: Nasra, Julie
Publisher: name: Imperial College London
Year: 2008

description: Cough is an important protective reflex. Sensory nerve activity mediating cough may be enhanced during disease. Current antitussives possess little clinical efficacy, therefore research is needed to investigate the modulation of airway sensory nerves in order to understand the mechanisms driving chronic cough. A conscious guinea-pig cough model using different tussive stimuli, known to elicit cough in man, was established. Corresponding in vitro effects of these tussive agents on sensory nerve activation were characterised. These agents were also characterised into sub-types as they produced distinct patterns of response. Cigarette smoke (CS) exposure elicited distinct effects on the cough reflex in conscious guinea-pigs and on sensory nerve activity measured in vitro; CS enhanced responses to citric acid (CA), capsaicin (CAPS) and bradykinin, inhibited a prostaglandin E2 (PGE2)-induced response and had no effect on the response to hypertonic saline. The CS model demonstrated neutrophilia and increased mucus in the airways. Focussing on mechanisms driving enhanced cough, revealed that nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF), may play a role in cough reflex sensitisation. An in vitro bioassay confirmed that NGF and BDNF exhibited bioactivity and the anticipated species cross-reactivity. CS exposure augmented the expression of transient receptor potential vanilloid 1 (TRPV1) in vagal sensory nerve ganglion. Pharmacological modulation of guinea-pig and human vagus nerve activation showed that TRPV1 antagonists, capsazepine and SB366791, abolished CAPS-induced depolarisation, partially inhibited low pH, bradykinin and PGE2-induced responses and had no effect on hypertonic saline. Despite positive in vitro and pharmacokinetic analyses, TRPV1 antagonists did not inhibit CAPS-induced cough in vivo. Further work is required to expand upon these findings. This thesis contains an assessment of the effects of sensory nerve modulation in guinea-pig models of cough. Understanding the neural mechanisms associated with this research may help to guide the development of novel antitussive therapies.
Collective coordinates, shape transitions and shape coexistence: a microscopic approach
Creators: name: Nakatsukasa, Takashi
name: Walet, Niels R.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We investigate a description of shape-mixing and shape-transitions using collective coordinates. To that end we apply a theory of adiabatic large-amplitude motion to a simplified nuclear shell-model, where the approximate results can be contrasted with exact diagonalisations. We find excellent agreement for different regimes, and contrast the results with those from a more standard calculation using a quadrupole constraint. We show that the method employed in this work selects diabatic (crossing) potential energy curves where these are appropriate, and discuss the implications for a microscopic study of shape coexistence.
description: 20 pages, including 6 ps files
Crack growth resistance in metallic alloys: the role of isotropic versus kinematic hardening
Creators: name: Martínez-Pañeda, Emilio
name: Fleck, Norman A.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The sensitivity of crack growth resistance to the choice of isotropic or kinematic hardening is investigated. Monotonic mode I crack advance under small scale yielding conditions is modelled via a cohesive zone formulation endowed with a traction-separation law. R-curves are computed for materials that exhibit linear or power law hardening. Kinematic hardening leads to an enhanced crack growth resistance relative to isotropic hardening. Moreover, kinematic hardening requires greater crack extension to achieve the steady state. These differences are traced to the non-proportional loading of material elements near the crack tip as the crack advances. The sensitivity of the R-curve to the cohesive zone properties and to the level of material strain hardening is explored for both isotropic and kinematic hardening.
description: Journal of Applied Mechanics (2018)
Propagation of Muons and Taus at High Energies
Creators: name: Dutta, S. Iyer
name: Reno, M. H.
name: Sarcevic, I.
name: Seckel, D.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The photonuclear contribution to charged lepton energy loss has been re-evaluated taking into account HERA results on real and virtual photon interactions with nucleons. With large $Q^2$ processes incorporated, the average muon range in rock for muon energies of $10^9$ GeV is reduced by only 5% as compared with the standard treatment. We have calculated the tau energy loss for energies up to $10^9$ GeV taking into consideration the decay of the tau. A Monte Carlo evaluation of tau survival probability and range show that at energies below $10^7-10^8$ GeV, depending on the material, only tau decays are important. At higher energies the tau energy losses are significant, reducing the survival probability of the tau. We show that the average range for tau is shorter than its decay length and reduce to 17 km in water for an incident tau energy of $10^9$ GeV, as compared with its decay length of 49 km at that energy. In iron, the average tau range is 4.7 km for the same incident energy.
description: 25 pages including 8 figures
MOESM11 of p53 modeling as a route to mesothelioma patients stratification and novel therapeutic identification
Creators: name: Tian, Kun
name: Bakker, Emyr
name: Hussain, Michelle
name: Guazzelli, Alice
name: Hasen Alhebshi
name: Meysami, Parisa
name: Constantinos Demonacos
name: Jean-Marc Schwartz
name: Mutti, Luciano
name: Krstic-Demonacos, Marija
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Additional file 11: Table S11. Approved drugs that target FEN1, MMP2 and SIAH1 indirectly and experimental drugs that target FEN1, MMP2 and SIAH1 directly or indirectly (DRUGSURV database).
The Frustration of being Odd: Universal Area Law violation in local systems
Creators: name: Giampaolo, Salvatore Marco
name: Ramos, Flávia Braga
name: Franchini, Fabio
Publisher: name: arXiv
Year: 2018
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: High Energy Physics - Theory (hep-th)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: At the core of every frustrated system, one can identify the existence of frustrated rings that are usually interpreted in terms of single--particle physics. We check this point of view through a careful analysis of the entanglement entropy of both models that admit an exact single--particle decomposition of their Hilbert space due to integrability and those for which the latter is supposed to hold only as a low energy approximation. In particular, we study generic spin chains made by an odd number of sites with short-range antiferromagnetic interactions and periodic boundary conditions, thus characterized by a weak, i.e. nonextensive, frustration. While for distances of the order of the correlation length the phenomenology of these chains is similar to that of the non-frustrated cases, we find that correlation functions involving a number of sites scaling like the system size follow different rules. We quantify the long-range correlations through the von Neumann entanglement entropy, finding that indeed it violates the area law, while not diverging with the system size. This behavior is well fitted by a universal law that we derive from the conjectured single--particle picture.
description: 19 Page, 5 figures. Updated with published version
Regulation of FoxO Transcription Factors in Breast Cancer
Creators: name: Pomeranz, Karen Miriam
Publisher: name: Imperial College London
Year: 2008

description: Breast cancer is the world’s most prevalent cancer. Although several drugs and chemotherapeutic strategies have been developed to tackle breast cancer, to date most patients eventually acquire resistance to these anticancer therapies. Therefore, identifying ways to increase the efficiency of currently used chemotherapeutic drugs and the development of new drugs for breast cancer treatment is essential. One way to achieve this goal is by identifying cellular targets which play a pivotal role in tumourigenesis and tumour progression. Paclitaxel belongs to a class of naturally occurring anti microtubule agents used for the treatment of malignancies such as breast cancer. Previous work has shown that FoxO3a, a transcription factor downstream of the phosphotidylinsitol-3-kinase/Akt signalling pathway, mediates apoptosis and cell cycle arrest in breast cancer cells in response to paclitaxel treatment. In order to elucidate the significance of FoxO expression and activation in response to paclitaxel treatment and oxidative stress (which is caused by paclitaxel treatment), I investigated the regulation of FoxO in endometrial and breast cancer cells. Both paclitaxel and oxidative stress were found to upregulate FoxO expression at the protein, mRNA and gene-promoter levels. Moreover, treatment with paclitaxel and hydrogen peroxide were shown to increase FoxO3a protein stability. Paclitaxel treatment resulted in JNK mediated nuclear accumulation of FoxO3a with a corresponding reduction in Akt activity. JNK was also shown to induce FoxO3a gene-promoter activity and to phosphorylate FoxO3a at two sites. These phosphorylation events may be important in the regulation of FoxO3a stability and activity. I also investigated the function of FoxO3a, by studying the role of BTG1, a downstream target of FoxO3a. I found that BTG1 expression was induced at the gene-promoter level by FoxO3a in MCF-7 cells. The use of a BTG1 inducible MCF-7 cell line revealed that over-expression of BTG1 results in changes in the expression levels of cell cycle regulators, reduction in cell growth and accumulation of cells in the G2/M phase of the cell cycle. Taken together, these results show that FoxO expression and activity are upregulated following paclitaxel treatment and demonstrate that the PI3K/Akt/FoxO and JNK signalling pathways cross-talk at least at two levels. Furthermore, these results indicate that FoxO expression levels may serve as bio-marker for determining the effectiveness of paclitaxel treatment of breast cancer patients and that FoxOs may serve as a potential target for anti-cancer chemotherapeutic intervention.
MOESM2 of Experimenting sensitivity-based anonymization framework in apache spark
Creators: name: Al-Zobbi, Mohammed
name: Shahrestani, Seyed
name: Ruan, Chun
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 2. Anonymizing numerical data by Scala programming.
Measuring Radial Orbit Migration in the Milky Way Disk
Creators: name: Frankel, Neige
name: Rix, Hans-Walter
name: Ting, Yuan-Sen
name: Ness, Melissa K.
name: Hogg, David W.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We develop and apply a model to quantify the global efficiency of radial orbit migration among stars in the Milky Way disk. This model parameterizes the possible star formation and enrichment histories, radial birth profiles, and combines them with a migration model that relates present-day orbital radii to birth radii through a Gaussian probability, broadening with age $τ$ as $σ_\mathrm{RM8}~\sqrt{τ/8{~\mathrm{Gyr}}}$. Guided by observations, we assume that stars are born with an initially tight age--metallicity relation at given radius, which becomes subsequently scrambled by radial orbit migration, thereby providing a direct observational constraint on radial orbit migration strength $σ_\mathrm{RM8}$. We fit this model with MCMC to the observed age--metallicity distribution of low-$α$ red clump stars with Galactocentric radii between 5 and 14 kpc from APOGEE DR12, sidestepping the complex spatial selection function and accounting for the considerable age uncertainties. This simple model reproduces well the observed data, and we find a global (in radius and time) radial orbit migration efficiency in the Milky Way of $σ_\mathrm{RM8}=3.6\pm 0.1$ kpc when marginalizing over all other model aspects. This shows that radial orbit migration in the Milky Way's main disk is indeed rather strong, in line with theoretical expectations: stars migrate by about a half-mass radius over the age of the disk. The model finds the Sun's birth radius at $\sim 5.2$ kpc. If such strong radial orbit migration is typical, this mechanism plays indeed an important role in setting the structural regularity of disk galaxies.
description: Submitted to ApJ, comments are welcome
Bosonic Realization of Boundary Operators in $SU(2)$-invariant Thirring Model
Creators: name: Hou, Boyu
name: Shi, Kangjie
name: Wang, Yanshen
name: Yang, Wenli
name: Chao, Liu
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Boundary operators and boundary states in $SU(2)$-invariant Thirring model are considered from the point of view of bosonization and oscillator realizations of bulk and boundary Zamolodchikov-Faddeev algebras.
description: 13 pages, LaTeX, No figures
Bonn Potential and Shell-Model Calculations for 206,205,204Pb
Creators: name: Coraggio, L.
name: Covello, A.
name: Gargano, A.
name: Itaco, N.
name: Kuo, T. T. S.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The structure of the nuclei 206,205,204Pb is studied interms of shell model employing a realistic effective interaction derived from the Bonn A nucleon-nucleon potential. The energy spectra, binding energies and electromagnetic properties are calculated and compared with experiment. A very good overall agreement is obtained. This evidences the reliability of our realistic effective interaction and encourages use of modern realistic potentials in shell-model calculations for heavy-mass nuclei.
description: 4 pages, 4 figures, submitted to Physical Review C
STUDIES TOWARDS LACTONAMYCIN: APPROACHES TO O-GLYCOSIDE FORMATION
Creators: name: Rzepa, Paula Rocha
Publisher: name: Imperial College London
Year: 2008

description: Please note: Abstract contains images which cannot be displayed. The total synthesis of lactonamycin (1), a natural product isolated from a soil sample, by Matsomoto and co-workers1 is currently under investigation. Lactonamycin (1) possesses antimicrobal activity against Gram-Positive bacteria including MRSA and VRE as well as appreciable levels of cytotoxicity against tumor cell lines. A highly oxygenated fused perhydrofuran-furanone structural motif and a naphtha[e]isoindole ring system make up the hexacylcic core of lactonamycin (1). Adding to the structural complexity, a 2,3,6-trideoxy sugar unit is connected to the core structure via a highly hindered tertiary glycosidic linkage. Various strategies for glycosidation, using the known ABCD alcohol (±)-2 as a model for the tertiary alcohol of lactonamycin (1) are discussed. Of these include, the use of classical glycosidation approaches and more novel strategies that employ open chain glycosyl donors. In particular, the synthesis of glycoside 4 and subsequent investigations towards target compound 5 are described.
MAP611.pdf
Creators: name: Coffey, Grant
Publisher: name: Crow Canyon Archaeological Center
Year: 2019
Subjects: Southwestern United States
Terminal Pueblo III
Ancestral Pueblo
Funerary and Burial Structures or Features
Non-Domestic Structures
Domestic Structure or Architectural Complex
Pollen
Ceramic
Chipped Stone
Dating Sample
Fauna
Ground Stone
Human Remains
Macrobotanical
Mineral
Architectural Documentation
Archaeological Overview
Site Evaluation / Testing

description: add description
title: ADCO, Ordre cistercien : comptes (1499-1515) (11 H 1162), f. 00244
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: comptes
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Ordre cistercien : comptes (1499-1515), Archives départementales de la Côte-d'Or, (11 H 1162). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Ordre cistercien : comptes (1499-1515), Archives départementales de la Côte-d'Or, (11 H 1162), f. 00244, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
MAP624.pdf
Creators: name: Coffey, Grant
Publisher: name: Crow Canyon Archaeological Center
Year: 2019
Subjects: Southwestern United States
Terminal Pueblo III
Ancestral Pueblo
Funerary and Burial Structures or Features
Non-Domestic Structures
Domestic Structure or Architectural Complex
Pollen
Ceramic
Chipped Stone
Dating Sample
Fauna
Ground Stone
Human Remains
Macrobotanical
Mineral
Architectural Documentation
Archaeological Overview
Site Evaluation / Testing

description: add description
MAP636.pdf
Creators: name: Coffey, Grant
Publisher: name: Crow Canyon Archaeological Center
Year: 2019
Subjects: Southwestern United States
Terminal Pueblo III
Ancestral Pueblo
Funerary and Burial Structures or Features
Non-Domestic Structures
Domestic Structure or Architectural Complex
Pollen
Ceramic
Chipped Stone
Dating Sample
Fauna
Ground Stone
Human Remains
Macrobotanical
Mineral
Architectural Documentation
Archaeological Overview
Site Evaluation / Testing

description: add description
Development of Novel Strategies for Musculoskeletal Tissue Engineering
Creators: name: Bonzani, Ian C.
Publisher: name: Imperial College London
Year: 2008

description: The drastic rise in the world’s population coupled to an ever increasing aging population poses a considerable challenge to the orthopaedic community to maintain healthy activity levels. The field of Tissue Engineering and Regenerative Medicine aims to tackle these challenges by implementing more biomimetic strategies to improve upon current treatments. The success of new therapeutic developments in musculoskeletal tissue engineering relies on our ability to study and understand the complex biological interactions between cells, materials, and native tissues so that we may subsequently guide neotissue formation. This thesis is focused on the development of novel, welldefined, and reproducible in-vitro tissue culture models to explore, characterise, and control cellular behaviour and differentiation for osteochondral regeneration. In particular, these models utilised combinations of polymeric biomaterials, differentiated osteoblasts, human periosteal stem cells, and physico-chemical cell signalling cues. In a commercial venture with PolyNovo Ltd (Melbourne, Australia), a novel two-component injectable polymer platform was synthesized and evaluated for uses as a biomaterial construct in orthopaedic applications. The second aspect of this thesis focuses on the harvest, isolation, expansion, and extensive characterisation of human periosteal cells in-vitro. The periosteum is a bi-layered membrane that covers the outside of cortical bone and has been recently identified as a potential stem cell source; with the ability to form osteogenic, chondrogenic, adipogenic, and myogenic tissue types. To detail the heterogeneous cellular features and behaviours of human periosteal cells in-vitro, cells were isolated from surgical explants, expanding in monolayer in the absence of differentiation supplements, and characterised for changes in morphology, growth rate, cell-cycle, gene expression, and phenotype. Additionally, enrichment techniques were designed to preferentially isolate distinct progenitor cell types identified in periosteal cell cultures. Most interestingly, a novel cell-sorting platform utilising droplet microfluidic approaches, was developed and evaluated for its ability to identify and separate periosteal progenitor cells. In the third part of this thesis, a 3-dimensional agarose culture model was created to control and monitor lineage specific human periosteal cell differentiation in various biomechanical and biochemical environments. The work presented herein further demonstrates the potential of human periosteal cells for osteochondral repair and more importantly provides critical information regarding human periosteal cell expansion, phenotype, and differentiation.
Safe, Site-specific Gene Delivery using Ultrasound and Microbubble Technology
Creators: name: Alete, Julia Alice
Publisher: name: Imperial College London
Year: 2008

description: The following study investigates the use of diagnostic ultrasound in combination with microbubbles (ultrasound contrast agents) as a physical enhancer for non-viral gene delivery. The aim of this work was firstly, to demonstrate that ultrasound exposure using settings within the range of diagnostic ultrasound, in combination with microbubbles can improve gene delivery, and secondly, to show that it is a safe, site-specific technique which mitigates the risk of tissue damage often seen with other physical enhancers of gene delivery such as, electroporation. Initially, a feasibility study was carried out to test the efficiency and safety of microbubble ultrasound (MBUS) in a reporter gene setting. Experiments using intravenous injections of a luciferase reporter gene established that MBUS is a safe, site-specific technique which improved levels of the luciferase expression in the organ targeted by MBUS. Luciferase was successfully delivered to the liver and heart, showing significantly higher levels compared to injections without MBUS, and with no detectable expression in other non-target organs. A therapeutic application of MBUS was tested using the mdx mouse, an animal model for Duchenne Muscular Dystrophy (DMD), a genetic disorder caused by the lack of functional dystrophin in muscle fibres due to premature termination of translation. The most successful treatment approach in the mdx mouse thus far had been the injection of Phosphorodiamidate Morpholino Oligomers (PMOs), which by inducing exon skipping, re-introduced dystrophin expression in most muscles in the body, with the exception of the heart. Injections of PMOs with MBUS to the heart successfully re-introduced dystrophin expression in cardiomyocytes. Furthermore, treatment parameters were investigated in more detail in order to optimize PMO delivery to the heart. Finally, an investigation into different types of commercially available microbubbles compared the efficiencies (with respect to gene delivery) of the different bubbles, in order to understand why different microbubbles show different results when used for MBUS, potentially enabling the design of microbubbles specifically for gene delivery.
MOESM10 of p53 modeling as a route to mesothelioma patients stratification and novel therapeutic identification
Creators: name: Tian, Kun
name: Bakker, Emyr
name: Hussain, Michelle
name: Guazzelli, Alice
name: Hasen Alhebshi
name: Meysami, Parisa
name: Constantinos Demonacos
name: Jean-Marc Schwartz
name: Mutti, Luciano
name: Krstic-Demonacos, Marija
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Additional file 10: Table S10. KEGG pathways.
A study of the adaptive immune system in coronary thromboaspirate during human acute myocardial infarction
Creators: name: Ghimire, Gopal
Publisher: name: Imperial College London
Year: 2010

description: Introduction: This thesis aims to characterize the biology of solid and liquid phase coronary thromboaspirate obtained during therapeutic aspiration at primary angioplasty for ST elevation myocardial infarction (STEMI). Methods: We studied coronary thromboaspirate obtained from the coronary artery (CA) in STEMI and focussed on three lines of investigation: • Intracoronary solid phase thrombus was subjected to immunohistochemistry for characterization and quantification of the different leukocyte types and proteins involved in the thrombus. • Resident cell populations in the liquid phase filtrate from the aspirate including platelets and leukocytes along with their subpopulations were analysed by flow cytometry for phenotypic and activation markers. Comparison was made with cells in the peripheral femoral artery (FA) blood. • Paired plasma/serum from the CA filtrate and FA blood were analysed for the presence of autoreactive antibodies and cytotoxic potential. Results: • Leukocytes were heterogeneously distributed in the ex-vivo thrombus. The granulocyte population was predominant and strongly expressed CD11b and vimentin. • The CA aspirate filtrate when compared to the paired FA blood contained significantly more leukocyte-platelet conjugates, more activated platelets, and more Vimentin. • More of the CD4+ T cells in the CA than FA had lost the co-stimulatory molecule CD28 (p<0.00001) and they often expressed effector phenotype marker. • Conversely, the immune-regulatory T cells expressing the FoxP3 were more attenuated in the CA than FA (p<0.00001). • Whilst IgG and IgM antivimentin antibody titres in the CA sera were consistently lower than the titres in FA sera (p<0.001), auto-reactive non-HLA IgM were more prevalent in CA sera. The CA sera had increased potential to induce apoptosis than FA sera when incubated with endothelial cells (p<0.001). Conclusions: • Aspirated intracoronary clot contained granulocytes as the predominant leukocyte component. This investigation of the immune system in the CA during AMI therefore moved on to the adaptive system in the coronary filtrate. • Increased concentrations of pro-inflammatory immune cells and reduced concentrations of immune-modulating cells were observed in the aspirate from the culprit site of CA occlusion when compared with the FA. The presence of T memory cells implies that this subset may have been released from the ruptured coronary plaque and this phenotypic analysis may help clarify the role of the immune system in the pathogenesis of coronary plaque instability. • The higher titres of auto-reactive IGM in the CA than FA sera have the potential to activate the complement system and may contribute to myocardial injury following therapeutic restoration of coronary flow in STEMI.
THE MOSDEF SURVEY: The Nature of Mid-Infrared Excess Galaxies and a Comparison of IR and UV Star Formation Tracers at z~2
Creators: name: Azadi, Mojegan
name: Coil, Alison
name: Aird, James
name: Shivaei, Irene
name: Reddy, Naveen
name: Shapley, Alice
name: Kriek, Mariska
name: Freeman, William R.
name: Leung, Gene C. K.
name: Mobasher, Bahram
name: Price, Sedona H.
name: Sanders, Ryan L.
name: Siana, Brian
name: Zick, Tom
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present an analysis using the MOSFIRE Deep Evolution Field (MOSDEF) survey on the nature of "MIR-excess" galaxies, which have star formation rates (SFR) inferred from mid-infrared (MIR) data that is substantially elevated relative to that estimated from dust-corrected UV data. We use a sample of $\sim$200 galaxies and AGN at $1.40
MOESM1 of Experimenting sensitivity-based anonymization framework in apache spark
Creators: name: Al-Zobbi, Mohammed
name: Shahrestani, Seyed
name: Ruan, Chun
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Plant Biology
subject: Computational Biology

description: Additional file 1. Taxonomy masking algorithm.
MAP642.pdf
Creators: name: Coffey, Grant
Publisher: name: Crow Canyon Archaeological Center
Year: 2019
Subjects: Southwestern United States
Terminal Pueblo III
Ancestral Pueblo
Funerary and Burial Structures or Features
Non-Domestic Structures
Domestic Structure or Architectural Complex
Pollen
Ceramic
Chipped Stone
Dating Sample
Fauna
Ground Stone
Human Remains
Macrobotanical
Mineral
Architectural Documentation
Archaeological Overview
Site Evaluation / Testing

description: add description
H-->WW as the discovery mode for a light Higgs boson
Creators: name: Kauer, N.
name: Plehn, T.
name: Rainwater, D.
name: Zeppenfeld, D.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The production cross section for a m_H=115 GeV, SM Higgs boson in weak boson fusion at the LHC is sizable. However, the branching fraction for H-->WW is expected to be relatively small. The signal, with its two forward jets, is sufficiently different from the main backgrounds that a signal to background ratio of better than 1:1 can nevertheless be obtained, with large enough rate to allow for a 5 sigma signal with 35 fb^{-1} of data. The H-->WW signal in weak boson fusion may thus prove to be the discovery mode for the Higgs boson at the LHC.
description: 10 pages, 4 figures, uses revtex
Additional file 1 of Decreased SFRP5 correlated with excessive metabolic inflammation in polycystic ovary syndrome could be reversed by metformin: implication of its role in dysregulated metabolism
Creators: name: Zhang, Yi
name: Ran, Yuxin
name: Kong, Lingna
name: Geng, Lihong
name: Huang, Hua
name: Zhang, Hongying
name: Hu, Jun
name: Qi, Hongbo
name: Chen, Ying
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: Additional file 1: Supplemental Table 1. Coefficient of variation for all metabolic assays.
Imaging pancreatic ß-cell in vivo using manganese-enhanced magnetic resonance imaging
Creators: name: Lee, Li Wen
Publisher: name: Imperial College London
Year: 2010

description: Diabetes is characterized by absolute or relative deficiency of insulin secretion by β-cells. Currently, there are no non-invasive diagnostic tools for assessing β-cell mass and function in situ. This thesis aims to develop and implement MRI techniques to image the β-cell in vivo. Calcium ion (Ca2+) entry occurs during insulin secretion and the manganese ion (Mn2+) has been used as a Ca2+ surrogate to study Ca2+ transport in β-cells. Mn2+ is also a positive T1 contrast agent and imaging [Mn2+] changes with manganese-enhanced MRI (MEMRI) may be used to monitor Ca2+ influx during insulin secretion. I hypothesize activated β-cells take up more manganese than resting cells after manganese chloride (MnCl2) administration; therefore, the glucose-stimulated pancreas may show higher signal intensity (SI) than the non-stimulated pancreas by T1-weighted MRI. Being thin and diffuse, the mouse pancreas is difficult to image. It was found to be best delineated by magnetization prepared rapid gradient echo (MP-RAGE) MRI. However, MP-RAGE is not conventionally used for quantitative studies and the relationship between MP-RAGE data and [Mn2+] have to be determined. First, an in vitro study was performed and showed a positive correlation between the effective R1 (R1-effective) values and [Mn2+]. Then, SI profiles and R1-effective values at increasing Mn2+ doses were obtained in the pancreas. Additionally, there was a linear correlation between tissue [Mn2+] by inductively-coupled plasma atomic emission spectrometry and R1-effective by MP-RAGE. The results showed that the MP-RAGE sequence can be used in a semi-quantitative manner. Subsequently, the methodology was applied to image the pancreas in vivo, with and without glucose challenge, in healthy and streptozotocin-induced diabetic mouse models. It revealed a statistically greater signal in the glucose-stimulated pancreas compared to control in healthy mice but not in diabetic mice. Further, Mn2+ infusion appeared to have minimal effects on blood glucose levels and islet morphology. Muscle glucose uptake is also a Ca2+-regulated process and therefore MEMRI was applied in the muscle. Results showed increased manganese uptake in glucose-stimulated muscle, suggesting MEMRI may be used for monitoring muscle glucose uptake. This thesis demonstrates an in vivo methodology to detect enhanced Mn2+ influx in the activated pancreas and skeletal muscle, opening up opportunities for assessing β-cell and skeletal muscle function during normal and abnormal glucose homeostasis.
Stacky GKM Graphs and Orbifold Gromov-Witten Theory
Creators: name: Liu, Chiu-Chu Melissa
name: Sheshmani, Artan
Publisher: name: arXiv
Year: 2018
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics

description: A smooth GKM stack is a smooth Deligne-Mumford stack equipped with an action of an algebraic torus $T$, with only finitely many zero-dimensional and one-dimensional orbits. (i) We define the stacky GKM graph of a smooth GKM stack, under the mild assumption that any one-dimensional $T$-orbit closure contains at least one $T$ fixed point. The stacky GKM graph is a decorated graph which contains enough information to reconstruct the $T$-equivariant formal neighborhood of the 1-skeleton (union of zero-dimensional and one-dimensional $T$-orbits) as a formal smooth DM stack equipped with a $T$-action. (ii) We axiomize the definition of a stacky GKM graph and introduce abstract stacky GKM graphs which are more general than stacky GKM graphs of honest smooth GKM stacks. From an abstract GKM graph we construct a formal smooth GKM stack. (iii) We define equivariant orbifold Gromov-Witten invariants of smooth GKM stacks, as well as formal equivariant orbifold Gromov-Witten invariants of formal smooth GKM stacks. These invariants can be computed by virtual localization and depend only the stacky GKM graph or the abstract stacky GKM graph. Formal equivariant orbifold Gromov-Witten invariants of the stacky GKM graph of a smooth GKM stack $\mathcal{X}$ are refinements of equivariant orbifold Gromov-Witten invariants of $\mathcal{X}$.
description: 38 pages; generalization of arXiv:1407.1370; Section 6 extends Section 9 of arXiv:1107.4712
Charge-Dependence of the Nucleon-Nucleon Interaction
Creators: name: Li, G. Q.
name: Machleidt, R.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Based upon the Bonn meson-exchange-model for the nucleon-nucleon ($NN$) interaction, we calculate the charge-independence breaking (CIB) of the $NN$ interaction due to pion-mass splitting. Besides the one-pion-exchange (OPE), we take into account the $2π$-exchange model and contributions from three and four irreducible pion exchanges. We calculate the CIB differences in the $^1S_0$ effective range parameters as well as phase shift differences for partial waves up to total angular momentum J=4 and laboratory energies below 300 MeV. We find that the CIB effect from OPE dominates in all partial waves. However, the CIB effects from the $2π$ model are noticable up to D-waves and amount to about 40% of the OPE CIB-contribution in some partial waves, at 300 MeV. The effects from 3$π$ and 4$π$ contributions are negligible except in $^1S_0$ and $^3P_2$.
description: 12 pages, RevTex, 14 figures