cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Mixed Wind Farm Optimzation
Creators: name: PJ Stanley
Publisher: name: figshare
Year: 2016
Subjects: subject: 90608 Renewable Power and Energy Systems Engineering (excl. Solar Cells)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: A paper discussing the optimization of a mixed turbine type wind farm including HAWTs and VAWTs
"21-asrda Gender tenglikning  mehnat munosabatidagi muammolari va dolzarb jihatlari "
Creators: name: Rajabova Zamira Ravshanbekovna
Publisher: name: Zenodo
Year: 2023

description: Annotatsiya: Ushbu maqolada gender stereotiplarining ayollar hayoti va faoliyatiga taʼsirini, xususan ularga nisbatan ishga kirishda, kasb tanlashda va mehnat faoliyati davomida kuzatiladigan diskriminatsiya holatlarini  va bu boradagi hal qilinishi kerak bo’lgan muammoli vaziatlar haqida so’z boradi.

Kalit so‘zlar:Ayollar huquqlari, gender tenglik, xotin-qizlar, qonun, mehnat,teng huquqlilik,gender masalalar.
Research on the Development and Management of Online Fitness Services
Creators: name: FANG, JI
Publisher: name: Monash University
Year: 2024
Subjects: classificationCode: 420302
subject: Digital health
classificationCode: 490108
subject: Operations research

description: This research project investigates the challenging issues stemming from the widespread adoption of the Internet of Things (IoT) by almost all healthcare service providers in recognising the heterogeneity of user attributes. From the perspective of a service provider, an innovative business model is needed to achieve a win-win outcome between the service provider and a high-quality user experience. However, the unique characteristics of users, eg., their physical heterogeneity, changing exercise preferences, and unpredictable behaviour, present challenges for health information systems. The thesis explored the current developments in online fitness services, focusing on the integration of IoT and Artificial Intelligence methodologies.
Optimization of a Fanduel Salary Cap League Fantasy Football Team.pdf
Creators: name: Smith, Matt
Publisher: name: figshare
Year: 2016
Subjects: subject: Computer Engineering
subject: Mechanical Engineering
subject: FOS: Mechanical engineering

description: One-day fantasy football leagues are becoming more popular each season and fantasy players are looking for any kind of advantage to win their leagues. One of these salary cap leagues is hosted by the website FanDuel. Fantasy Football team owners can improve their chances to win by selecting an optimized team based off the previous week’s statistics. Two methods were written in order to maximize the total points scored by a FanDuel roster with a salary cap constraint. We implemented MATLAB’s built-in genetic algorithm function to create an optimal lineup based on the projected points per game of each player, and reliable lineups based on the uncertainty of each player to achieve a minimum target score. The genetic algorithm proved to be the best gradient-free optimization method for this approach. Gradient-free methods will help fantasy football team owners select a roster that helps them select a roster each week that will maximize their points while not going over the allotted salary cap. The discussed optimization methods can easily be applied to other fantasy sport leagues with a salary cap.
tornado-observation-application.pdf
Creators: name: Okeson, Trent
name: Packer, Ryan
Publisher: name: figshare
Year: 2016
Subjects: subject: Aerospace Engineering
subject: FOS: Mechanical engineering

description: Tornadoes are devastating natural disasters that not only destroy communities and accumulate property damage that amounts to millions of dollars but also affect the lives of many people. Extensive research has been done to improve tornado detection and help meteorologists better understand these storms through atmospheric data collection. Unmanned aerial vehicles (UAV's) have been used to collect data and observe storms in safer and more meaningful ways. A common problem that remains is how to effectively use this technology with human error and the costs of damaging the UAV. The focus of this paper was to optimize the flight path of a UAV to be as close as possible to a tornado but also allow for a safe landing away from the tornado. This was accomplished by first creating a two-dimensional, stationary tornado environment for the UAV to fly through. In this environment a circular vortex was created which had wind speeds reaching near 110 miles per hour. The flight path was optimized by minimizing the distance between the UAV and the tornado and constraining the path based on energy costs and landing feasibility. The optimized path resulted in a smooth flight plan that came as close as 25 m from the tornado and ended in wind speeds less than 1 m/s. The applications of these results range from improving UAV storm observation, collecting more meaningful data, and decreasing flight error due to human control to reducing the costs of damaged UAV's.
Optimization of a Prosthetic Foot Designed by 2ft Prosthetics
Creators: name: Quinn, Steven
name: Quinn, Chris
name: Whipple, Nicholas
Publisher: name: figshare
Year: 2016
Subjects: subject: 90399 Biomedical Engineering not elsewhere classified
subject: FOS: Medical engineering

description: Optimization of a prosthetic foot design.
LEGO® Metadaten für die Reproduzierbarkeit
Creators: name: Biernacka, Katarzyna
Publisher: name: Zenodo
Year: 2020
Subjects: Forschungsdaten
Schulungsmaterialien
Forschungsdatenmanagement
Dokumentation
Metadaten
FDM
Training
Schulung

description: Dies ist eine deutsche Übersetzung von dem englischsprachigen LEGO® Metadata for Reproducibility von Donaldson, M. and Mahon, M.: Donaldson, M. and Mahon, M. (2019); LEGO® Metadata for Reproducibility. University of Glasgow. DOI: http://dx.doi.org/10.36399/gla.pubs.196477' Die Methode LEGO® Metadaten für die Reproduzierbarkeit ist eine interaktive Schulungsmethode für 4-24 Spieler, bei dem LEGO® den Forschenden hilft, die Metadaten zu bestimmen, die sie für eine bessere Reproduzierbarkeit vergeben müssen. Die Methode befasst sich unter anderem mit der Planung für die Erstellung von Metadaten, den Formaten für die Sammlung/Generierung von Metadaten, Standards und der Automatisierung. Die Methode zieht auch mehrere Parallelen zwischen der Erfassung und Kommunikation des Forschungsprozesses, und der Dokumentation und der Erstellung eines Lego-Modells. Die Methode regt die Forschenden zu Diskussionen darüber an, wie Metadaten erfasst und verbreitet werden, was wiederum die Möglichkeit bietet, auf weitere Ressourcen in diesem Bereich hinzuweisen. Das Spielepaket ist in zwei Formen erhältlich - die erste enthält PDF-Dateien, die in ihrer aktuellen Form ausgedruckt und verwendet werden können. Das zweite Paket ist editierbar - es enthält die gleichen Dokumente im .docx-Format, so dass diese bearbeitet werden können, um sie an lokale Gegebenheiten anzupassen.
Optimization of a Graded Multi-Material Composite Flywheel
Creators: name: Newton, Cory
name: Crampton, Erica B.
name: Rosquist, Parker G.
Publisher: name: figshare
Year: 2016
Subjects: subject: 91202 Composite and Hybrid Materials
subject: FOS: Materials engineering
subject: Mechanical Engineering
subject: FOS: Mechanical engineering
subject: 10303 Optimisation
subject: FOS: Mathematics

description: Storing energy is a challenge given the fleeting nature of elemental energy. Flywheels were developed to solve this problem of energy storage by transferring unused energy into controlled rotational motion with the ability to transfer it back into usable energy. Flywheel design has evolved significantly and the most sophisticated and expensive flywheels incorporate composite materials. This paper introduces a novel multi-objective approach to flywheel design where composite materials are optimally mixed together to produce the maximum amount of rotational energy while minimizing the cost for production. To determine the best mixture of materials, coefficients for a polynomial model describing this mixture are treated as design variables. This model is then optimized for every combination of fiber materials over a range of cost constraints, resulting in a Pareto front of optimal material combinations. This Pareto front provides insight into cost versus performance trends for a graded multi-material flywheel and can be used as a decision making tool for industries in flywheel design.
High-power test stand setup and final results of the high-power tests
Creators: name: I.FAST WP7 members
Publisher: name: Zenodo
Year: 2025

description: Work Package 7.4 aims to design, construct, and test two very high-gradient (above 150 MV/m at the cathode) C-band (5.712 GHz) electron RF guns. The first of these RF guns is a Standing-Wave (SW) type, featuring 2.5 accelerating cells, while the second is a multi-cell Traveling-Wave (TW) structure that incorporates the photocathode in the very first cell. This Milestone report presents details of the RF test stand and the results of the high-power tests conducted on the two fabricated guns.
THEORY OF ORGANIZATIONAL AGILITY THROUGH COMMUNICATION: THE SCRUM MODEL
Creators: name: SANTIAGO, SHIRLEY FERAER
Publisher: name: Zenodo
Year: 2023

description: The digital revolution, often referred to as the third industrial revolution, began with the shift from analog and mechanical devices to digital technology in the second half of the twentieth century. It enabled the market to respond rapidly to customer preferences and implement changes according to market conditions and business environments. In this era of digital revolution, Agile development has become highlyvalued among organizations as they need to innovate faster than ever before to survive and thrive in an ever-changing and competitive business climate and respond to marketplace changes by developing new and innovative products, modernizing existing ones, or shifting business models. Without organizational agility, they risk being left behind or becoming obsolete. Amidst these challenges, the Agile paradigm, a product development approach that addresses business agility and deals with rapid change, rose from the software development industry. There are various types of Agile frameworks that help organizations become more agile, with Scrum being the most widely used. Scrum is a framework in product development that helps people, teams, and organizations generate value as they navigate through complexities. While many organizations in information technology, banking, insurance, healthcare, fuel, energy, and power generation are adopting Scrum, some still find it challenging to embrace it to improve their agility. In this research, I aimed to discover how organizations can better adopt an Agile mindset to keep up with the digital revolution. I conducted a comprehensive study on organizational agility and the Scrum framework and analyzed how both relate to three fundamental communication theories: Theory of Diffusion of Innovation, System Theory, and Behavioral Theory. Through sensemaking, I studied organizations that have adopted Scrum and examined why Agile is vital to organizations, what hinders organizations from adopting the Agile mindset, and how Scrum can help organizations adopt the agility mindset. Additionally, through a case study, I explored how Scrum can be used as a communication tool among geographically distributed teams. In this research, I discovered three essential factors in the successful adoption of organizational agility, namely, (1) principles and praxis; (2) mindset and behavior; and (3) innovation. These three pillars have one crucial aspect in common: communication. The results of my research show that these factors will help organizations in the paradigm shift from traditional product development to a more value-driven approach. Using the lenses of the Interpretative School and Montreal School of Thought in organizational communication, the results also support the premise that acts of communication in the Scrum Model can improve agility in organizations.
Final Report.pdf
Creators: name: Fanning, Tate
name: Searle, Matthew
Publisher: name: figshare
Year: 2016
Subjects: subject: Aerospace Engineering
subject: FOS: Mechanical engineering
subject: 90199 Aerospace Engineering not elsewhere classified

description: We develop an analytical model for the head loss in a stepped converging-diverging (CD) nozzle through which liquid water flows. Under these conditions, the liquid water is modeled as steady and incompressible. The CD nozzle is composed of a series of finite steps. The head loss including major and minor losses is obtained for a variable number of steps as a function of the area of each step and the length of these stepped segments. The optimization problem considered here is to obtain the set of cross-sectional areas which minimize head loss. For the diffuser, we constrain each cross-sectional area in a segment to be greater than or equal to the area of the segment immediately upstream. For the nozzle, we constrain each cross-sectional area in a segment to be less than or equal to the area of the segment immediately upstream. We consider a constraint where we specify the velocity at a specific segments of the nozzle and of the diffuser supposing that measurements or process requirements mandate this constraint. Under these constraints, we obtain the optimal head loss and corresponding design variables for cases including or excluding friction and for cases with and without the velocity constraint. We find that minimizing minor losses dominates the selection of cross-sectional areas. The optimal solution adapts to the addition of major losses by increasing the areas of each segment slightly. We find that the concavity of the optimal cross-sectional area profile depends on the length of the diffuser with concave-up profiles encountered for short lengths and profiles which transition from concave-up to concave-down for longer lengths.
Carbon Fiber Beam Optimization
Creators: name: Sacks, Derek
Publisher: name: figshare
Year: 2016
Subjects: subject: 91202 Composite and Hybrid Materials
subject: FOS: Materials engineering

description: A Matlab program was written to optimize the design of a carbon ber I-Beam for the conditionsand constraints provided by the Utah SAMPE competition. This program has an objective function tominimize the mass of the beam subject to stress constraints. The variables that comprise the solutionspace are the ange width, the web height, the layer thicknesses as well as the layer orientations. Theprogram utilizes a user-supplied starting point for each of the design variables and a gradient basedoptimization technique (fmincon, using SQP method) to nd the minimum mass of the beam subject tothe constraints. The rules given by the Utah SAMPE committee are that the beam must hold a weightof 15,000 pounds, be no more than 4 x4 inches while spanning a 24 gap, and be able to accommodatea distributed load of 4 x4 administered as a three point bending test. The program returns the optimalbeam dimensions, the weight of the beam, the stress in each layer, as well as the optimal layer orientations.
THEORY OF ORGANIZATIONAL AGILITY  THROUGH COMMUNICATION:  THE SCRUM MODEL
Creators: name: SANTIAGO, SHIRLEY FERAER
Publisher: name: Zenodo
Year: 2023

description: The digital revolution, often referred to as the third industrial revolution, began with the shift from analog and mechanical devices to digital technology in the second half of the twentieth century. It enabled the market to respond rapidly to customer preferences and implement changes according to market conditions and business environments. In this era of digital revolution, Agile development has become highlyvalued among organizations as they need to innovate faster than ever before to survive and thrive in an ever-changing and competitive business climate and respond to marketplace changes by developing new and innovative products, modernizing existing ones, or shifting business models. Without organizational agility, they risk being left behind or becoming obsolete. Amidst these challenges, the Agile paradigm, a product development approach that addresses business agility and deals with rapid change, rose from the software development industry. There are various types of Agile frameworks that help organizations become more agile, with Scrum being the most widely used. Scrum is a framework in product development that helps people, teams, and organizations generate value as they navigate through complexities. While many organizations in information technology, banking, insurance, healthcare, fuel, energy, and power generation are adopting Scrum, some still find it challenging to embrace it to improve their agility. In this research, I aimed to discover how organizations can better adopt an Agile mindset to keep up with the digital revolution. I conducted a comprehensive study on organizational agility and the Scrum framework and analyzed how both relate to three fundamental communication theories: Theory of Diffusion of Innovation, System Theory, and Behavioral Theory. Through sensemaking, I studied organizations that have adopted Scrum and examined why Agile is vital to organizations, what hinders organizations from adopting the Agile mindset, and how Scrum can help organizations adopt the agility mindset. Additionally, through a case study, I explored how Scrum can be used as a communication tool among geographically distributed teams. In this research, I discovered three essential factors in the successful adoption of organizational agility, namely, (1) principles and praxis; (2) mindset and behavior; and (3) innovation. These three pillars have one crucial aspect in common: communication. The results of my research show that these factors will help organizations in the paradigm shift from traditional product development to a more value-driven approach. Using the lenses of the Interpretative School and Montreal School of Thought in organizational communication, the results also support the premise that acts of communication in the Scrum Model can improve agility in organizations.
Overcoming difficulties on synthesis of cardiac troponin-I
Creators: name: S. Mert Selimoglu
name: Kasap, Murat
name: Gurler Akpinar
name: Karadenizli, Aynur
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Human cardiac troponin-I (cTnI) is one of the most sensitive and specific indicators, used in the diagnosis of myocardial infarction. To produce the protein efficiently, Escherichia coli and Pichia pastoris systems were used. Initial trials for the expression in E. coli were not successful, although different expression vectors with different promoters were tested. This led us to use P. pastoris for the expression. After several trials with two different expression strains of P. pastoris, it was concluded that P. pastoris was also not an optimal expression host for cTnI. Comprehensive analysis of the expression systems indicated that an efficient expression is only possible when the gene is optimized for expression in E. coli. For this purpose, the gene was optimized in-silico, but edited manually afterwards. It was synthesized and cloned into pQE-2 vector. Expression was performed using routine experimental conditions. Thus, cTnI could be efficiently expressed from the optimized gene in E. coli. The expression and purification were practical and may be used for commercial purposes since a total yield of 25µg highly pure protein per milliliter of culture could be obtained. The protein was in its ready-to-use form for many biological applications, including as a standard in diagnostic tests and an antigen for antibody production.
Investigating gilding techniques on Gandharan stone sculptures and architectural components: a preliminary note
Creators: name: Ramasso, Claudia
Publisher: name: Restauro Archeologico
Year: 2019

description: Taking into account the reports on archaeological excavation and the resulting successive publications, the present article wants to define the exact place of origin and an accurate dating for a schist bracket showing traces of gilding, currently preserved in the MAO Museo d’Arte Orientale in Turin (Inv. n. IAp/151). The bracket has been unearthed during excavations carried out between 1956 and 1962 by the Missione Archeologica Italiana at the site of Butkara I (Pakistan). In 2016, the conspicuous gilding still present and the bole underneath it have been scientifically analyzed by the ISCR, Istituto Superiore per la Conservazione e il Restauro based in Rome. At present, the ISCR is carrying out important studies at international level on the polychromy and the gilding of stone and stucco elements pertaining to the Buddhist artistic production of the ancient region of Gandhara, an area at present situated between the two nation-states of Pakistan and Afghanistan.
description: Restauro Archeologico, Vol. 27 No. 1 (2019)
Clays and colours: Tracking technologies and theories of vision in the ancient Buddhist art of Afghanistan
Creators: name: Forgione, Giulia
Publisher: name: Restauro Archeologico
Year: 2019

description: New, targeted and comparative studies are under way on clay sculptures recovered in Afghanistan, thanks to a collaborative project between the Italian Archaeological Mission in Afghanistan and the Archaeology Institute of Afghanistan. The specific target of the preliminary analyses are the sculptures from the Buddhist site of Tapa Sardar, which have been excavated between the 1960’s and the 1970’s by the Italian mission in the Ghazni area, and those, only partially published, that have been brought to light at Tepe Narenj, a site in the Kabul area under excavation since 2004 under the aegis of the Archaeology Institute of Afghanistan. Our aim is to analyse their physical, technical, stylistic and iconographic features, in order to identify patterns that might be associated to a coherent aesthetic system. This would be of fundamental importance to the understanding of the ideological frames of reference that shaped the art-making process in a period of great artistic vitality and innovations, which roughly spans the second half of the first millennium A.C.
description: Restauro Archeologico, Vol. 27 No. 1 (2019)
SHOLI POYASINI DIMETILSULFOKSID VA ULTRATOVUSH YORDAMIDA ISHLOV BERISH TEXNOLOGIYASI
Creators: name: Urozov, M.
name: Yusupova, N.F.
name: Usmanova, Z.U.
Publisher: name: Zenodo
Year: 2024

description: Ultratovush kuchini ko‘proq darajada oshirish GS fraktsiyasi tarkibidagi sholi poyasi biomassasidan va kamroq darajada lignin fraktsiyasi tarkibidagi aralashmalarni olib tashlashga yordam beradi.
Collections gandhariennes et afghanes à Paris, Musée national des arts asiatiques-Guimet
Creators: name: Cambon, Pierre
Publisher: name: Restauro Archeologico
Year: 2019

description: Les collections de Paris occupent une position singulière en Europe parce qu’elles font le lien entre les collections anglaises, ou bien encore allemandes, largement gandhariennes, au sens de Peshawar (Londres, British Museum; Berlin, Museum für Asiatische Kunst), et les collections italiennes, qui, elles, renvoient généralement au Swat (Rome, Museo Nazionale d’Arte Orientale «Giuseppe Tucci», maintenant fusionné dans le Museo delle Civiltà).
description: Restauro Archeologico, Vol. 27 No. 1 (2019)
One-pot multicomponent diastereoselective synthesis of novel dihydro-1H-furo[2,3-c]pyrazoles
Creators: name: Venkata Swamy Tangeti
name: G. V. Siva Prasad
name: Jagadeesh Panda
name: K. Ramesh Varma
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology

description: An efficient method was developed for the diastereoselective synthesis of novel fused dihydro-1H-furo[2,3-c]pyrazole by a one-pot, four-component reaction of β-keto ester, hydrazine, aromatic aldehyde, and pyridinium ylide in the presence of triethylamine under microwave irradiation in solvent-free conditions in good yields. The merits of this cascade Knoevenagel condensation/Michael addition/cyclization sequence include its high atom economy, good yields, and efficiency of producing three new bonds (two C–C and one C–O) and two stereocenters in a single operation.
The Gandharan Collection of the Civic Archaeological Museum of Milan
Creators: name: Provenzali, Anna
Publisher: name: Restauro Archeologico
Year: 2019

description: The Civic Archaeological Museum of Milan holds a small but remarkable collection of Gandharan Art, acquired by the former Director Ermanno Arslan, between the 70s and the 90s of the 20th century. Archaeological method, that is to say contextualization, must apply also to objects without provenance. Cultural diversity is the starting point to understand/detect relations, connections, mutual interferences between cultures. Through museum exhibitions, we can transmit the notion that archaeological objects, more than being works of art to be admired for their beauty, are a cluster of various information regarding the ancient culture to which they belong.
description: Restauro Archeologico, Vol. 27 No. 1 (2019)
Effects of pre- and postnatal exposure to extremely low-frequency electric fields on mismatch negativity component of the auditory event-related potentials: Relation to oxidative stress
Creators: name: Akpınar, Deniz
name: Gok, Deniz Kantar
name: Hidisoglu, Enis
name: Mutay Aslan
name: Sukru Ozen
name: Agar, Aysel
name: Piraye Yargicoglu
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: In our previous study, the developmental effects of extremely low-frequency electric fields (ELF-EF) on visual and somatosensory evoked potentials in adult rats were studied. There is no study so far examining the effects of 50 Hz electric field (EF) on mismatch negativity (MMN) recordings after exposure of rats during development. Therefore, our present study aimed to investigate MMN and oxidative brain damage in rats exposed to EF (12 kV/m, 1 h/day). Rats were divided into four groups, namely control (C), prenatal (Pr), postnatal (Po), and prenatal+postnatal (PP). Pregnant rats of Pr and PP groups were exposed to EF during pregnancy. Following birth, rats of PP and Po groups were exposed to EF for three months. After exposure to EF, MMN was recorded by electrodes positioned stereotaxically to the surface of the dura, and then brain tissues were removed for histological and biochemical analyses. The MMN amplitude was higher to deviant tones than to standard tones. It was decreased in all experimental groups compared with the C group. 4-Hydroxy-2-nonenal (4-HNE) levels were significantly increased in the Po group with respect to the C group, whereas they were significantly decreased in the PP group compared with Pr and Po groups. Protein carbonyl levels were significantly decreased in the PP group compared with C, Pr, and Po groups. EF decreased MMN amplitudes were possibly induced by lipid peroxidation.
Large-scale meta-analysis of human medial frontal cortex reveals tripartite functional organization
Creators: name: Vega, Alejandro De La
name: Chang, Luke J
name: Banich, Marie T
name: Wager, Tor D
name: Yarkoni, Tal
Publisher: name: figshare
Year: 2016
Subjects: Neuroscience

description: The functional organization of human medial frontal cortex (MFC) is a subject of intense study. Using functional magnetic resonance imaging (fMRI), the MFC has been associated with diverse psychological processes including motor function, cognitive control, affect, and social cognition. However, there have been few large-scale efforts to comprehensively map specific psychological functions to sub-regions of medial frontal anatomy. Here we applied a meta-analytic data-driven approach to nearly 10,000 fMRI studies to identify putatively separable regions of MFC and determine which psychological states preferentially recruit their activation. We identified regions at several spatial scales on the basis of meta-analytic co-activation, revealing three broad functional zones along a rostro-caudal axis composed of 2-4 smaller sub-regions each. Multivariate classification analyses aimed at identifying the psychological functions most strongly predictive of activity in each region revealed a tripartite division within MFC, with each zone displaying a relatively distinct functional signature. The posterior zone was associated preferentially with motor function, the middle zone with cognitive control, pain, and affect, and the anterior with reward, social processing and episodic memory. Within each zone, the more fine-grained sub-regions showed distinct, but subtler, variations in psychological function. These results provide hypotheses about the functional organization of medial prefrontal cortex that can be tested explicitly in future studies.
Modelling prognostic trajectories of cognitive decline due to Alzheimer's disease.
Creators: name: Giorgio, Joseph
name: Landau, Susan M
name: Jagust, William J
name: Tino, Peter
name: Kourtzi, Zoe
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Cognition
Machine Learning
Mild Cognitive Impairment
Alzheimer's Disease Brain Imaging

description: Alzheimer's disease (AD) is characterised by a dynamic process of neurocognitive changes from normal cognition to mild cognitive impairment (MCI) and progression to dementia. However, not all individuals with MCI develop dementia. Predicting whether individuals with MCI will decline (i.e. progressive MCI) or remain stable (i.e. stable MCI) is impeded by patient heterogeneity due to comorbidities that may lead to MCI diagnosis without progression to AD. Despite the importance of early diagnosis of AD for prognosis and personalised interventions, we still lack robust tools for predicting individual progression to dementia. Here, we propose a novel trajectory modelling approach based on metric learning (Generalised Metric Learning Vector Quantization) that mines multimodal data from MCI patients in the Alzheimer's disease Neuroimaging Initiative (ADNI) cohort to derive individualised prognostic scores of cognitive decline due to AD. We develop an integrated biomarker generation- using partial least squares regression- and classification methodology that extends beyond binary patient classification into discrete subgroups (i.e. stable vs. progressive MCI), determines individual profiles from baseline (i.e. cognitive or biological) data and predicts individual cognitive trajectories (i.e. change in memory scores from baseline). We demonstrate that a metric learning model trained on baseline cognitive data (memory, executive function, affective measurements) discriminates stable vs. progressive MCI individuals with high accuracy (81.4%), revealing an interaction between cognitive (memory, executive functions) and affective scores that may relate to MCI comorbidity (e.g. affective disturbance). Training the model to perform the same binary classification on biological data (mean cortical β-amyloid burden, grey matter density, APOE 4) results in similar prediction accuracy (81.9%). Extending beyond binary classifications, we develop and implement a trajectory modelling approach that shows significantly better performance in predicting individualised rate of future cognitive decline (i.e. change in memory scores from baseline), when the metric learning model is trained with biological (r = -0.68) compared to cognitive (r = -0.4) data. Our trajectory modelling approach reveals interpretable and interoperable markers of progression to AD and has strong potential to guide effective stratification of individuals based on prognostic disease trajectories, reducing MCI patient misclassification, that is critical for clinical practice and discovery of personalised interventions.
Catalyst-free synthesis of 3-(1-arylsulfonylalkyl)indoles via three-component reaction of indoles, carbonyls, and arenesulfinic acids
Creators: name: Wenzhong Huang
name: Yang, Juan
name: Xiangguang Li
name: Yuan, Lin
name: Yinhai Ma
name: Qinglong Zhou
name: Deqiang Liang
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: A catalyst-free three-component reaction of indoles, carbonyls, and arenesulfinic acids performed at room temperature provides direct access to biologically important 3-(1-arylsulfonylalkyl)indoles. This process features mild conditions, low cost, broad substrate scope, and high yields, and mechanistically bis(indolyl)methanes were identified as the key intermediates.
Effectiveness of influenza vaccine against influenza A in Europe in seasons of different A(H1N1)pdm09 and the same A(H3N2) vaccine components (2016–17 and 2017–18)
Creators: name: Kissling, Esther
name: Pozo, Francisco
name: Buda, Silke
name: Vilcu, Ana-Maria
name: Rizzo, Caterina
name: Gherasim, Alin
name: Horváth, Judit Krisztina
name: Brytting, Mia
name: Domegan, Lisa
name: Meijer, Adam
name: Paradowska-Stankiewicz, Iwona
name: Machado, Ausenda
name: Višekruna Vučina, Vesna
name: Lazar, Mihaela
name: Johansen, Kari
name: Dürrwald, Ralf
name: Van Der Werf, Sylvie
name: Bella, Antonino
name: Larrauri, Amparo
name: Ferenczi, Annamária
name: Zakikhany, Katherina
name: O'Donnell, Joan
name: Dijkstra, Frederika
name: Bogusz, Joanna
name: Guiomar, Raquel
name: Kurečić Filipović, Sanja
name: Pitigoi, Daniela
name: Penttinen, Pasi
name: Valenciano, Marta
name: I-MOVE/I-MOVE+ Study Team
Publisher: name: Robert Koch-Institut
Year: 2019
Subjects: subject: Influenza
subject: Influenza vaccine
subject: Vaccine effectiveness
subject: multicentre study
subject: Case-control study
subject: Europe
subject: 610 Medizin und Gesundheit

description: Introduction Influenza A(H3N2) viruses predominated in Europe in 2016–17. In 2017–18 A(H3N2) and A(H1N1)pdm09 viruses co-circulated. The A(H3N2) vaccine component was the same in both seasons; while the A(H1N1)pdm09 component changed in 2017–18. In both seasons, vaccine seed A(H3N2) viruses developed adaptations/alterations during propagation in eggs, impacting antigenicity. Methods We used the test-negative design in a multicentre primary care case-control study in 12 European countries to measure 2016–17 and 2017–18 influenza vaccine effectiveness (VE) against laboratory-confirmed influenza A(H1N1)pdm09 and A(H3N2) overall and by age group. Results During the 2017–18 season, the overall VE against influenza A(H1N1)pdm09 was 59% (95% CI: 47–69). Among those aged 0–14, 15–64 and ≥65 years, VE against A(H1N1)pdm09 was 64% (95% CI: 37–79), 50% (95% CI: 28–66) and 66% (95% CI: 42–80), respectively. Overall VE against influenza A(H3N2) was 28% (95% CI: 17–38) in 2016–17 and 13% (95% CI: −15 to 34) in 2017–18. Among 0–14-year-olds VE against A(H3N2) was 28% (95%CI: −10 to 53) and 29% (95% CI: −87 to 73), among 15–64-year-olds 34% (95% CI: 18–46) and 33% (95% CI: −3 to 56) and among those aged ≥65 years 15% (95% CI: −10 to 34) and −9% (95% CI: −74 to 32) in 2016–17 and 2017–18, respectively. Conclusions Our study suggests the new A(H1N1)pdm09 vaccine component conferred good protection against circulating strains, while VE against A(H3N2) was <35% in 2016–17 and 2017–18. The egg propagation derived antigenic mismatch of the vaccine seed virus with circulating strains may have contributed to this low effectiveness. A(H3N2) seed viruses for vaccines in subsequent seasons may be subject to the same adaptations; in years with lower than expected VE, recommendations of preventive measures other than vaccination should be given in a timely manner.
One Pot Multicomponent Diastereoselective Synthesis of Novel dihydro-1 H -furo[2,3- c ]pyrazoles
Creators: name: Venkata Swamy Tangeti
name: G. V. Siva Prasad
name: Jagadeesh Panda
name: K, Ramesh Varma.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology

description: An efficient method was developed for the diastereoselective synthesis of novel fused dihydro-1H-furo[2,3-c]pyrazole by a one-pot four-component reaction of β-keto ester, hydrazine, aromatic aldehyde and pyridinium ylide in the presence of triethylamine under microwave-irradiation in solvent-free conditions in good yields. The merit of this cascade Knoevenagel condensation/Michael addition/cyclization sequence is highlighted by its high atom-economy, good yields, efficiency of producing three new bonds (two C–C and one C–O), and two stereo centers in a single operation.
Editorial do n.º normal de dezembro da Indagatio Didactica
Creators: name: Bettencourt, Teresa
Publisher: name: Indagatio Didactica
Year: 2019

description: O presente número da Revista Online Indagatio Didactica é composto por dezassete artigos distribuídos por quatro secções distintas. Começando pela rubrica Supervisão, esta é composta por quatro trabalhos, seguidos de três incluídos na secção Tecnologias da Informação em Educação. Passamos depois à rubrica Supervisão com cinco artigos, para terminar com outros cinco trabalhos inseridos na secção Desenvolvimento Curricular e Didática. Importa informar que, mais uma vez, recebemos um elevado número de submissões de propostas, continuando a reafirmar-se a vitalidade e o interesse internacional da Revista. Aos novos autores e aos revisores que gentilmente aceitaram o convite endereçado reiteramos o nosso reconhecido agradecimento. Bem como agradecemos o trabalho empenhado e altamente profissional e responsável de todos os revisores e autores que, num curtíssimo espaço de tempo – pouco mais de dois meses, contribuíram para que esta edição viesse a contar com um número considerável de artigos, todos eles de qualidade. Os quatro trabalhos inseridos na rubrica Supervisão centram-se em problemáticas distintas abarcando populações que vão desde estudantes do ensino superior à educação de infância, passando pelo contexto da prática de ensino supervisionada.
description: Indagatio Didactica, vol. 11 n.º 4 (2019)
INNOVATE ON A SHOESTRING - Product development for the Least Developed Countries and what we can re-use in the Established Markets
Creators: name: Ottosson, Hans
Publisher: name: figshare
Year: 2016
Subjects: subject: 120403 Engineering Design Methods
subject: FOS: Other engineering and technologies
subject: 91503 Engineering Practice

description: By understanding current approaches and methods of product development (PD) combined with knowledge of the needs and know-how of customers in the least developed countries (LDCs) associated risks and excessive costs can be avoided. The main purpose of this thesis is to highlight the important need of developing products and services for the LDCs and to look at current practices for PD and to distill these into one method for developing products pertinent to LDC needs and markets. Conversely, the second purpose for this thesis is to examine possible LDC based development tools that can be applicable when designing for the more established markets. There are also crucial social, cultural, economic and political reasons for addressing LDC related issues. The goal is to show companies of all sizes that it can be profitable to expand to new markets in the LDCs and also that the steps used there can help generate new revenue when implemented in their current markets, as well as to provide them a model for it. This thesis includes and clearly demonstrates the importance of development involvement on the local level and the benefit of using complementors. The thesis data and conclusions are based on literature studies and an extended stay in the Dominican Republic. It is here observed that by getting closer to the end customer, a company will get an increased understanding and knowledge that provides an advantage over the competition. And for companies to succeed in the LDCs, the three most significant things to consider are: 1) to find the specific needs of the customer, 2) design for affordability, and 3) to source and manufacture locally. It will be seen that the benefits to such an approach extend outward in essentially all directions.
Informe de investigación B-Learning CETE 2016.pdf
Creators: name: González, Byron
Publisher: name: figshare
Year: 2016
Subjects: subject: 130103 Higher Education
subject: FOS: Educational sciences

description: Se indaga sobre la experiencia estudiantil de usar una combinación de métodos de aprendizaje cara a cara y en línea en un curso ordinario de la carrera de Ingeniería Agronómica en la Universidad de San Carlos de Guatemala
Spatial Distribution and Molecular Diversity of Archaeal Communities in the Extreme Hypersaline Meromictic Brâncoveanu Lake (Transylvanian Basin, Romania)
Creators: name: Adrian-Ştefan Andrei
name: Baricz, Andreea
name: Păuşan, Manuela
name: Muntean, Vasile
name: Sicora, Cosmin Ionel
name: Alexe, Mircea
name: Rakosy-Tican, Elena
name: Banciu, Horia Leonard
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Dating from the Middle Miocene, the massive halite deposits lying beneath the Transylvanian Basin (Central Romania) have been valuable mineral resources quarried for millennia. Among the numerous hypersaline pit lakes that resulted from this mining, Brâncoveanu Lake is unique by its extreme salinity. Assessment of physicochemical variables, water chemistry and trophic status indicated that Brâncoveanu Lake is a permanently stratified, pH-neutral, NaCl-rich and eutrophied system. We investigated the abundance, molecular diversity and vertical distribution of archaeal community by culture-independent approaches. Additionally, the most relevant environmental parameters shaping the archaeal community composition were evaluated by statistical methods. Archaea appeared to largely outnumber Bacteria; altogether the great prevalence of Halobacteriaceae-related sequences could imply a major contribution of this group to the biogeochemical carbon turnover. The fairly distinct composition of archaeal communities reflects the lake's physicochemical stratification. Among the limnological factors, salinity and oxygen showed a significant impact on determining the composition and structure of archaeal assemblages. Furthermore, Brâncoveanu Lake might harbor novel microorganisms such as members of the recently described phylum Nanohaloarchaea. Overall, this study reported the occurrence of halophilic Archaea in a little explored hydrogeochemical system and provided a better insight into geomicrobiology of meromictic hypersaline pit lakes.
Pondscape: Schöneiche. (German version)
Creators: name: Mehner, Thomas
name: Paula, Mehner
name: Lemmens, Pieter
name: von Plüskow, Maria Louise
Publisher: name: Zenodo
Year: 2024
Subjects: Pondscape
Wetland
Ponds
Biodiversity
Nature-based solutions
Ecosystem services
Nature Contribution to people
Best practices

description: This Leaflet concerns the German pondscape "Schöneiche".

In the framework of the project PONDERFUL, a synthetic “leaflet” has been developed for each of thepondscapes making part of DEMO-sites implemented across Europe, Turkey and Uruguay. The main objective of the leaflets is to present a selection of science-based success stories in the implementation of pondscapes as Nature-based Solutions (NbS) for addressing societal challenges (such as climate change and biodiversity loss), and to promote the transferability of these practices elsewhere. The success stories are evidenced in this leaflet by the measurement of indicators of the NatureContribution to People, and by a cost-benefit analysis.

The leaflets were written and designed to interest and inspire professionals in land use planning andmanagement of natural areas, people active in NGOs, and also for a wider and more varied public.The information provided in the leaflet is intentionally simplified to avoid excessive jargon andscientific complexity and to remain accessible and understandable to a broad audience.
Electron-donating capabilities and evidence for redox activity in low oxidation state iron complexes bearing bis(amidine)pyrimidylidene ligands
Creators: name: Hilan Z. Kaplan
name: Mako, Teresa L.
name: Wilding, Matthew J. T.
name: Li, Bo
name: Byers, Jeffery A.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Low-valent iron complexes bearing bis(amidine)pyrimidylidene (or carbenodiamidine, CDA) ligands have been synthesized and characterized by X-ray crystallography, Mössbauer spectroscopy, infrared spectroscopy, EPR spectroscopy, and DFT calculations. One electron reduction of (CDA)FeCl2 (1) resulted in the formation of (CDA)FeCl (2), which demonstrated an unusual metal−N-heterocyclic carbene (NHC) interaction where a redox non-innocent NHC participates in a one electron π-interaction with the metal center. This interaction renders the complex best described as a low-spin iron(II) complex that is antiferromagnetically coupled to a singly reduced CDA ligand. Two electron reduction of 1 under an atmosphere of carbon monoxide resulted in the formation of the diamagnetic complex (CDA)Fe(CO)2 (3). Complex 3 demonstrated significantly lower CO stretching frequencies compared to previously reported bis(imino)pyridine and even bis(N-heterocyclic carbene)pyridine iron complexes, which reflects the significant σ-donating capabilities of the CDA ligands.