cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The ciliary protein RPGRIP1L governs autophagy independently of its proteasome-regulating function at the ciliary base in mouse embryonic fibroblasts
Creators: name: Struchtrup, Andreas
name: Wiegering, Antonia
name: Stork, Björn
name: Rüther, Ulrich
name: Gerhardt, Christoph
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Science Policy
subject: Developmental Biology

description: Previously, macroautophagy/autophagy was demonstrated to be regulated inter alia by the primary cilium. Mutations in RPGRIP1L cause ciliary dysfunctions resulting in severe human diseases summarized as ciliopathies. Recently, we showed that RPGRIP1L deficiency leads to a decreased proteasomal activity at the ciliary base in mice. Importantly, the drug-induced restoration of proteasomal activity does not rescue ciliary length alterations in the absence of RPGRIP1L indicating that RPGRIP1L affects ciliary function also via other mechanisms. Based on this knowledge, we analyzed autophagy in Rpgrip1l-negative mouse embryos. In these embryos, autophagic activity was decreased due to an increased activation of the MTOR complex 1 (MTORC1). Application of the MTORC1 inhibitor rapamycin rescued dysregulated MTORC1, autophagic activity and cilia length but not proteasomal activity in Rpgrip1l-deficient mouse embryonic fibroblasts demonstrating that RPGRIP1L seems to regulate autophagic and proteasomal activity independently from each other.
Memories of William Cameron Shaw OBE
Creators: name: Project Team, Their Finest Hour
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: I have come to tell you about my paternal grandfather, William Cameron Shaw. He was a commander in the Navy. Originally, he was with the Merchant Navy and he got seconded into the navy during WWII. He ended up getting an OBE. I have brought along the OBE.
I have a photograph of him.
I have a photocopy of the London Gazette.
I have a newspaper clipping of him showing a Duchess his boat.
I have his field medical card. He was discharged on medical grounds. I have also brought along a picture of my maternal grandfather - Peter Manderson - with the Home Guard. I also have a photo of my Dad, William Cameron Shaw. He was seconded into the Royal Scottish Fusiliers after the war. He was given a commission second lieutenant and discharged in 1948.
title: ADCO, Huitième cartulaire de Saint-Étienne de Dijon (1661-1667), Cart. 31 (G 135), 549 folios, f. 0467
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Huitième cartulaire de Saint-Étienne de Dijon (1661-1667), Archives départementales de la Côte-d'Or, Cart. 31 (G 135), 549 folios, f. 0467, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Huitième cartulaire de Saint-Étienne de Dijon (1661-1667), Archives départementales de la Côte-d'Or, Cart. 31 (G 135), 549 folios, f. 0467, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Prognostic and predictive biomarkers of abdominal aortic aneurysm growth rate
Creators: name: Deeg, Mark A.
name: Arnoud Meijer, C.
name: Chan, Lai Shan
name: Shen, Lei
name: H. N. Lindeman, Jan
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Physiology
subject: Pharmacology
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Objectives: To test the utility of clinical and circulating biomarkers to predict abdominal aortic aneurysm (AAA) growth rate and response to doxycycline therapy. Methods: Plasma samples were obtained in the Pharmaceutical Aneurysm Stabilization Trial that tested the effect of doxycycline (n = 44) vs. placebo (n = 49) in patients with a 35–50 mm AAA. Approximately 200 biomarkers were evaluated in a candidate approach that included markers of matrix turnover and cathepsin S activity and a broad-based approach of predominantly inflammation-related and clinical biomarkers. Results: In a recursive partitioning based analysis, total cholesterol, baseline AAA size, and apolipoprotein B were prognostic of AAA growth in the placebo group whereas elastin and biglycan degradation products were predictive of AAA growth with doxycycline treatment. Univariate analysis of these biomarkers showed that baseline total cholesterol (r = 0.38, unadjusted P = 0.011), apolipoprotein B (r = 0.41, unadjusted P = 0.005), and baseline AAA size (r = 0.35, unadjusted P = 0.013) correlated with AAA growth in the placebo but not the doxycycline group. Elastin fragments were associated with 18 month AAA growth (r = 0.33, unadjusted P = 0.031) in the doxycycline group. Limitations: Limitations of this study include small sample size, a retrospective growth analysis, and translatability of the method used to measure the analytes. Conclusions: This study implies that total cholesterol, baseline AAA size, and apolipoprotein B are predictors of AAA growth. Levels of elastin and biglycan fragments are predictive of doxycycline effects on AAA growth and provide a clue towards this unexpected negative effect.
First Spectroscopic Confirmations of z ~ 7.0 Lya Emitting Galaxies in the LAGER Survey
Creators: name: Hu, Weida
name: Wang, Junxian
name: Zheng, Zhenya
name: Malhotra, Sangeeta
name: Infante, Leopoldo
name: Rhoads, James
name: Gonzalez, Alicia
name: Walker, Alistair R.
name: Jiang, Linhua
name: Jiang, Chunyan
name: Hibon, Pascale
name: Barrientos, L. Felipe
name: Finkelstein, Steven
name: Galaz, Gaspar
name: Kang, Wenyong
name: Kong, Xu
name: Tilvi, Vithal
name: Yang, Huan
name: Zheng, XianZhong
Publisher: name: arXiv
Year: 2017
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Narrowband imaging is a highly successful approach for finding large numbers of high redshift Lya emitting galaxies (LAEs) up to z~6.6. However, at z>~7 there are as yet only 3 narrowband selected LAEs with spectroscopic confirmations (two at z~6.9-7.0, one at z~7.3), which hinders extensive studies on cosmic reionization and galaxy evolution at this key epoch. We have selected 23 candidate z~6.9 LAEs in COSMOS field with the large area narrowband survey LAGER (Lyman-Alpha Galaxies at the End of Reionization). In this work we present spectroscopic followup observations of 12 candidates using IMACS on Magellan. For 9 of these, the observations are sufficiently deep to detect the expected lines. Lya emission lines are identified in six sources (yielding a success rate of 2/3), including 3 luminous LAEs with Lya luminosities of L(Lya) ~ 10^{43.5} erg/s, the highest among known spectroscopically confirmed galaxies at >~7.0. This triples the sample size of spectroscopically confirmed narrowband selected LAEs at z>~7, and confirms the bright end bump in the Lya luminosity function we previously derived based on the photometric sample, supporting a patchy reionization scenario. Two luminous LAEs appear physically linked with projected distance of 1.1 pMpc and velocity difference of ~ 170 km/s. They likely sit in a common ionized bubble produced by themselves or with close neighbors, which reduces the IGM attenuation of Lya. A tentative narrow NV$λ$1240 line is seen in one source, hinting at activity of a central massive black hole with metal rich line emitting gas.
description: 6 pages, 3 figures, 2 tables, accepted by ApJL
The role of frame analysis in cognitive semantics for understanding how language encodes and expresses gender concepts and issues.
Creators: name: Safarova Zarnigor Zohid's daughter
Publisher: name: Zenodo
Year: 2024

description: Annotation: This article explores the influence of gender-related terms on cognitive processes through the lens of cognitive semantics and frame analysis. It examines the impact of grammatical gender on semantic categorization and implicit associations, highlighting the role of language in shaping our understanding of gender. The article discusses the relationship between language, cognition, and gender, providing insights into the cognitive underpinnings of gender-related terms.

Keywords: Cognitive semantics, gender, frame analysis, language, social meaning cognition, grammatical gender, semantic categorization, gender terms, societal norms.
Electron temperature and tunnel coupling dependence of zero-bias and almost-zero-bias conductance peaks in Majorana nanowires
Creators: name: Setiawan, F.
name: Liu, Chun-Xiao
name: Sau, Jay D.
name: Sarma, S. Das
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: A one-dimensional semiconductor nanowire proximitized by a nearby superconductor may become a topological superconductor hosting localized Majorana zero modes at the two wire ends in the presence of spin-orbit coupling and Zeeman spin splitting (arising from an external magnetic field). The hallmark of the presence of such Majorana zero modes is the appearance of a zero-temperature quantized zero-bias conductance peak in the tunneling spectroscopy of the Majorana nanowire. We theoretically study the temperature and the tunnel coupling dependence of the tunneling conductance in such nanowires to understand possible intrinsic deviations from the predicted conductance quantization. We find that the full temperature and the tunneling transmission dependence of the tunnel conductance does not obey any simple scaling relation, and estimating the zero-temperature conductance from finite-temperature and finite-tunnel-broadening tunneling data is difficult in general. A scaling relation, however, does hold at the extreme weak-tunneling low-temperature limit where the conductance depends only on the dimensionless ratio of the temperature and tunnel broadening. We also consider the tunneling contributions from nontopological Andreev bound states which may produce almost-zero-bias conductance peaks, which are not easy to distinguish from the Majorana-induced zero-bias peaks, finding that the nontopological almost-zero-modes associated with Andreev bound states manifest similar temperature and transmission dependence as the topological Majorana modes. We comment on the Zeeman splitting dependence of the zero-bias conductance peak for finite temperature and tunnel coupling.
description: 21 pages, 30 figures. Published version
Оценка влияния блокатора АТ1-рецепторов ангиотензина II валсартана на регресс постинфарктного ремоделирования левого желудочка, нарушение микроциркуляции и инсулинорезистентности у больных ИБС, отягощенной сахарным диабетом 2-го типа
Creators: name: Нижегородцев М. Ю.
name: Тепляков А. Т.
name: Кузнецова А. В.
name: Лукинов А. В.
name: Горюцкий В. Н.
Publisher: name: Сибирский медицинский журнал (Томск)
Year: 2009
Subjects: ИБС
СД 2-го типа
валсартан
постинфарктное ремоделирование
инсулинорезистентность
антиишемические эффекты
микроциркуляция
IHD
diabetes mellitus of the 2-nd type
valtarsan
postinfarction remodeling
Insulin resistance
anti-ischemic effects
Microcirculation

description: Изучались антиишемические, кардиопротективные, гемодинамические и метаболические эффекты, а также влияние на регресс нарушений микроциркуляции инсулинорезистентности блокатора АТ1-рецепторов ангиотензина II валсартана в комбинации с тиазидным диуретиком гидрохлортиазидом во вторичной профилактике хронической сердечной недостаточности у больных с постинфарктным ремоделированием левого желудочка, ишемической дисфункцией сердца, отягощенной СД 2-го типа. В исследование включено 25 пациентов в среднем возрасте 59,2±5,8 лет. В ходе 3-месячной курсовой терапии блокатором АТ1-рецепторов А II валсартаном в индивидуально подобранной дозе 106,0±36,3 мг/сут в комбинации с гидрохлортиазидом в дозе 18,7±6,2 мг/сут отмечена высокая антиишемическая и кардиопротективная эффективность, а также положительное влияние на углеводный обмен и липидный спектр крови. По результатам исследования установлен существенный рост физической толерантности на 42,6%. Дистанция 6-минутной ходьбы возросла на 43,3%. Это сопутствовало регрессу коронарной недостаточности. Качество жизни улучшилось на 13,7%. В ходе исследования произошел регресс массы миокарда ЛЖ на 10,9%, а также улучшение диастолической функции ЛЖ. Показатели микроциркуляторного русла (МЦР) претерпевали положительные изменения, выражающиеся увеличением резервного кровотока на фоне уменьшения влияния атерогенной дислипопротеидемии, а также снижения степени инсулинорезистентности на 41,2%, базальной гипергликемии на 25,3% и постпрандиальной гликемии на 15,6%, косвенно отражающих пропорциональный регресс тканевой инсулинорезистентности.
description: Anti-ischemic, cardioprotective, hemodynamic and metabolic affects as well as influence on regress of insulin resistance microcirculation injuries of valtarsan which was used in combination with tiasid diuretics hydrochlortiasid were studied in the secondary prevention of chronic heart failure in patients with left ventricular postinfarction remodeling, ischemic cardiac dysfunction aggravated with the diabetes mellitus of the 2-nd type. The study included 25 patients aged 59,2±5,8 years. Results of 3-months treatment with these drugs revealed their high anti-ischemic and cardioprotective efficacy. The study results showed markedly increased physical tolerance and quality of life of such patients.
Biopiracy,Trips Review and the Inadequacy of the National Contract-Based Approach: a Developing Countries’ Perspective
Creators: name: Abdelgawad, Walid
Publisher: name: figshare
Year: 2018
Subjects: subject: 180107 Conflict of Laws (Private International Law)
subject: FOS: Law
subject: 180106 Comparative Law
subject: 180105 Commercial and Contract Law
subject: 180111 Environmental and Natural Resources Law
subject: 180115 Intellectual Property Law
subject: 180117 International Trade Law
subject: Law

description: In order to tackle Biopiracy under the form of erroneously granted patents, many developing countries have proposed to amend the Trips agreement to introduce a mandatory disclosure requirement of the origin of biological resources and associated traditional knowledge in patent applications within the framework of the TRIPS Council’s work. To oppose this initiative, the United Stated and Japan, have launched the “national contract-based approach” and have argued that the best way to address the misappropriation of these resources would be to refer to bilateral contracts based on national laws in order to regulate the access and benefit sharing. This legal framework may use private international law mechanisms such as the choice of law and international arbitration. It could also refer to additional tools like databases on traditional knowledge and patents re-examination proceedings. This article seeks to conduct a critical examination and assessment of the American and Japanese proposal and to demonstrate the inadequacy of the “national contract-based approach” to prevent biopiracy and effectively protect indigenous communities and developing countries’ interests. It proves that this approach contains many disadvantages for developing countries for several reasons: its misjudgement of the international dimension of biopiracy, its very high transaction cost, its dismissal of the widespread economic impact of biopiracy and their discriminatory, unbalanced and unfair features for developing countries. This article also reveals the failure of the private international law mechanisms and of the free market based solution to protect the weak party in international bioprospecting contracts and to effectively fight against biopiracy.
Automated Techniques for Measuring Metadata Quality
Creators: name: Spencer, Samuel
name: White, Harry
Publisher: name: Zenodo
Year: 2019
Subjects: metadata
data curation
quality insurance

description: Modern statistical agencies and data library put an increased focus on metadata assets alongside traditional data products. However, as the volume of data grows data managers face increasing volumes of information requiring quality assurance. To combat this techniques for automating quality checks within metadata systems are required to help data managers improve throughput of data into data catalogues and archives.

 While there is still significant expertise in gauging the correctness and quality of content, more basic tasks such as checking for the presence of fields, simple spelling and grammar checks, and uniqueness of codes are all within the realm of automated systems.

 In this presentation we present the techniques used in the Aristotle Metadata Registry to build automated workflows for ensuring metadata quality at all stages of the data lifecycle. These techniques cover new methods for authoring machine actionable metadata quality rules, asynchronous systems for continuous quality checking, and user interfaces that quickly and accurately present results to users.
Wren from World War Two Kathleen Clandillon
Creators: name: Project Team, Their Finest Hour
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: I'd like to tell the story of my mother, Kathleen Clandillon.She was in the Wrens, the womens service. She was serving on bases from where the fleet air arm where flying as an observer. Even though they were air fields it was given a royal name. So she was at HMS Vulture (in Cornwall), HMS Nightjar (in Lancashire) and HMS Landrail (in the Mull of Kintyre). She was eventually promoted to third officer. The main aircraft they were flying from the airfields were Gloster Gladiators. They did not fly they did general admin duties. When they did practice runs they were marking where bombs were dropped for accuracy. I have brought along photographs - they used to visit boats. She was usually the one designated to row the boat! She had to make sure they were back on shore by midnight. A photo of her waiting for the other Wrens to come off the boat. Photos of drones for target practice.

I have also brought along a photo from the Wren magazine of her death. She died in 1991.
Non-equilibrium 2D Ising model with stationary uphill diffusion
Creators: name: Colangeli, Matteo
name: Giardinà, Cristian
name: Giberti, Claudio
name: Vernia, Cecilia
Publisher: name: arXiv
Year: 2017
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Usually, in a non-equilibrium setting, a current brings mass from the highest density regions to the lowest density ones. Although rare, the opposite phenomenon (known as "uphill diffusion") has also been observed in multicomponent systems, where it appears as an artificial effect of the interaction among components. We show here that uphill diffusion can be a substantial effect, i.e. it may occur even in single component systems as a consequence of some external work. To this aim we consider the 2D ferromagnetic Ising model in contact with two reservoirs that fix, at the left and the right boundaries, magnetizations of the same magnitude but of opposite signs. We provide numerical evidence that a class of non-equilibrium steady states exists in which, by tuning the reservoir magnetizations, the current in the system changes from "downhill" to "uphill". Moreover, we also show that, in such non-equilibrium set-up, the current vanishes precisely when the reservoir magnetizations equal the magnetization of the corresponding equilibrium dynamics, thus establishing a novel relation between equilibrium and non-equilibrium properties.
Innovative Biomimetic Collagen-based Scaffolds for Enhanced and Longer Lasting Cartilage Repair
Creators: name: Intini, Claudio
Publisher: name: Royal College of Surgeons in Ireland
Year: 2022
Subjects: subject: Stem Cells
subject: 60405 Gene Expression (incl. Microarray and other genome-wide approaches)
subject: FOS: Biological sciences
subject: Cell Biology
subject: Anatomy
subject: 100404 Regenerative Medicine (incl. Stem Cells and Tissue Engineering)
subject: FOS: Medical biotechnology

description: This thesis has led to the development of a novel highly porous collagen-based scaffold for enhanced and longer lasting cartilage repair, by incorporating type II collagen (CII) and hyaluronic acid (HyA) within a type I collagen (CI) framework. This newly developed CI/II-HyA scaffold biomaterial has demonstrated to effectively regenerate high-quality cartilage-like tissue in vitro with promise to provide stable and long-term performance in vivo for cartilage repair. Furthermore, this platform was successfully adapted to deliver gene therapy, specifically involving the development of an innovative microRNA-activated scaffold which offers greater control of the mesenchymal stem cell (MSC) chondrogenic processes, and possibly enhanced cartilage repair in the clinic. These scaffold systems show good promise for simple and effective “off the shelf” application in patients for cartilage repair.
Supplemental material for Mapping fault geomorphology with drone-based lidar
Creators: name: Salomon, Guy
Publisher: name: Zenodo
Year: 2024
Subjects: lidar
point cloud
LASTools

description: This supplemental material includes shell scripts for the classification and rasterization of point cloud data collected by a UAV laser scanning (ULS) system (point_cloud_processing.sh and raster_difference.sh). It also includes additional visualizations. The additional figures include flight lines for each study site, comparisons made along the Eastern Denali Fault that were not included within the publication, and point cloud profiles through typical vegetation types found within in each case study.
Testing statistical Isotropy in Cosmic Microwave Background Polarization maps
Creators: name: Rath, Pranati K.
name: Samal, Pramoda Kr.
name: Panda, Srikanta
name: Mishra, Debesh D.
name: Aluri, Pavan K.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We apply our symmetry based Power tensor technique to test conformity of PLANCK Polarization maps with statistical isotropy. On a wide range of angular scales (l=40-150), our preliminary analysis detects many statistically anisotropic multipoles in foreground cleaned full sky PLANCK polarization maps viz., COMMANDER and NILC. We also study the effect of residual foregrounds that may still be present in the galactic plane using both common UPB77 polarization mask, as well as the individual component separation method specific polarization masks. However some of the statistically anisotropic modes still persist, albeit significantly in NILC map. We further probed the data for any coherent alignments across multipoles in several bins from the chosen multipole range.
description: 11 pages, 6 figures, Accepted for publication in MNRAS
مدى مساهمة التكوين أثناء الخدمة في تحسين الخدمات التوجيهية والارشادية من وجهة نظر مستشاري التوجيه والإرشاد المدرسي والمهني ( دراسة ميدانية بمركز التوجيه المدرسي والمهني بولاية بسكرة )
Creators: name: Mhamel, Imad Eddine
Publisher: name: figshare
Year: 2022
Subjects: subject: 130199 Education systems not elsewhere classified
subject: FOS: Educational sciences

description: هدفت الدراسة إلى الكشف عن مدى مساهمة التكوين أثناء الخدمة في تحسين الخدمات التوجيهية والإرشادية من وجهة نظر مستشاري التوجيه والإرشاد المدرسي والمهني لولاية بسكرة، أجريت الدراسة على (85) فردا، تم معاينة (33) منهم بطريقة قصدية (2020 -2021)، تم استخدام المنهج الوصفي الاستكشافي التحليلي، وتم بناء استبيان مكون من (39) فقرة موزعة على(3) بدائل هي درجة مساهمة (قليلة، متوسطة، كبيرة)، تم حساب الخصائص السيكومترية للأداة، قام الباحث بقياس درجة مساهمة التكوين أثناء الخدمة في تحسين الخدمات التوجيهية والإرشادية من وجهة نظر مستشاري التوجيه والارشاد وتوصل إلى النتائج الآتية : - يساهم التكوين أثناء الخدمة في تحسين الخدمات التوجيهية والارشادية من وجهة نظر مستشاري التوجيه والإرشاد المدرسي والمهني بدرجة متوسطة. يساهم التكوين أثناء الخدمة في تحسين: - خدمات الاعلام المدرسي بدرجة متوسطة. - خدمات التوجيه المدرسي بدرجة كبيرة. - خدمات الارشاد والمرافقة النفسية بدرجة متوسطة. - خدمات التقييم والمتابعة بدرجة متوسطة. - خدمات تربية الاختيارات المدرسية والمهنية بدرجة كبيرة.
Design and standalone characterisation of a capacitively coupled HV-CMOS sensor chip for the CLIC vertex detector
Creators: name: Kremastiotis, I.
name: Ballabriga, R.
name: Campbell, M.
name: Dannheim, D.
name: Fiergolski, A.
name: Hynds, D.
name: Kulis, S.
name: Peric, I.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: The concept of capacitive coupling between sensors and readout chips is under study for the vertex detector at the proposed high-energy CLIC electron positron collider. The CLICpix Capacitively Coupled Pixel Detector (C3PD) is an active High-Voltage CMOS sensor, designed to be capacitively coupled to the CLICpix2 readout chip. The chip is implemented in a commercial $180$ nm HV-CMOS process and contains a matrix of $128\times128$ square pixels with $25$ $μ$m pitch. First prototypes have been produced with a standard resistivity of $\sim20$ $Ω$cm for the substrate and tested in standalone mode. The results show a rise time of $\sim20$ ns, charge gain of $190$ mV/ke$^{-}$ and $\sim40$ e$^{-}$ RMS noise for a power consumption of $4.8$ $μ$W/pixel. The main design aspects, as well as standalone measurement results, are presented.
description: 13 pages, 13 figures, 2 tables. Work carried out in the framework of the CLICdp collaboration
Strengthening mental health through optimism
Creators: name: Jans-Beken, Lilian
Publisher: name: figshare
Year: 2018
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: The current study aimed to examine demographic determinants of optimism, and prospective associations between optimism and measures of well-being and psychopathology, using a three-wave prospective survey design in a large general population sample of Dutch adults. Optimism showed significant positive correlations with age and education level. Optimism did not longitudinally predict psychological complaints when adjusting for the effects of demographic factors, and previous levels of psychological complaints and well-being. Optimism was, however, a significant positive longitudinal predictor of well-being, also when adjusting for the effects of demographic factors, and prior levels of well-being and psychological complaints. Our findings indicate that optimism as a disposition shows complex connections with the presence of well-being and absence of psychopathology, in line with a multidimensional representation of mental health.
Additional file 6 of A novel immune checkpoints-based signature to predict prognosis and response to immunotherapy in lung adenocarcinoma
Creators: name: Sun, Nan
name: Luo, Yuejun
name: Zheng, Bo
name: Zhang, Zhihui
name: Zhang, Chaoqi
name: Zhang, Zhen
name: Zhang, Guochao
name: Tan, Fengwei
name: Xue, Qi
name: Gao, Shugeng
name: He, Jie
Publisher: name: figshare
Year: 2022
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 6: Table S1. Primer Sequences for q-PCR. Table S2. Univariate Cox proportional regression analysis of the valued prognostic genes in TCGA cohort.
Relative quasimaps and mirror formulae
Creators: name: Battistella, Luca
name: Nabijou, Navid
Publisher: name: arXiv
Year: 2017
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14N35

description: We construct and study the theory of relative quasimaps in genus zero, in the spirit of Gathmann. When $X$ is a smooth toric variety and $Y$ is a smooth very ample hypersurface in $X$, we produce a virtual class on the moduli space of relative quasimaps to $(X,Y)$, which we use to define relative quasimap invariants. We obtain a recursion formula which expresses each relative invariant in terms of invariants of lower tangency, and apply this formula to derive a quantum Lefschetz theorem for quasimaps, expressing the restricted quasimap invariants of $Y$ in terms of those of $X$. Finally, we show that the relative $I$-function of Fan-Tseng-You coincides with a natural generating function for relative quasimap invariants, providing mirror-symmetric motivation for the theory.
description: 32 pages, 1 figure; comments welcome. v2: added a stronger version of the quantum Lefschetz theorem. v3: additional section exploring applications to relative mirror symmetry, new title and introduction. v4: final version published in IMRN
Stochastic Electron Acceleration by the Whistler Instability in a Growing Magnetic Field
Creators: name: Riquelme, Mario
name: Osorio, Alvaro
name: Quataert, Eliot
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We use 2D particle-in-cell (PIC) simulations to study the effect of the saturated whistler instability on the viscous heating and nonthermal acceleration of electrons in a shearing, collisionless plasma with a growing magnetic field, \textbf{B}. In this setup, an electron pressure anisotropy with $p_{\perp,e} > p_{||,e}$ naturally arises due to the adiabatic invariance of the electron magnetic moment ($p_{||,e}$ and $p_{\perp,e}$ are the pressures parallel and perpendicular to \textbf{B}). If the anisotropy is large enough, the whistler instability arises, efficiently scattering the electrons and limiting $Δp_e$ ($\equiv p_{\perp,e}-p_{||,e}$). In this context, $Δp_e$ taps into the plasma velocity shear, producing electron heating by the so called anisotropic viscosity. In our simulations, we permanently drive the growth of $|\textbf{B}|$ by externally imposing a plasma shear, allowing us to self-consistently capture the long-term, saturated whistler instability evolution. We find that besides the viscous heating, the scattering by whistler modes can stochastically accelerate electrons to nonthermal energies. This acceleration is most prominent when initially $β_e\sim 1$, gradually decreasing its efficiency for larger values of $β_e$ ($\equiv 8πp_e/|\textbf{B}|^2$). If initially $β_e \sim 1$, the final electron energy distribution can be approximately described by a thermal component, plus a power-law tail with spectral index $\sim 3.7$. In these cases, the nonthermal tail accounts for $\sim 5\%$ of the electrons, and for $\sim 15\%$ of their kinetic energy. We discuss the implications of our results for electron heating and acceleration in low-collisionality astrophysical environments, such as low-luminosity accretion flows.
description: 7 pages, 6 figures, accepted in The Astrophysical Journal
DDI 4 - The Potential as a Metadata Standard for Cross-Domain Research Data
Creators: name: Wackerow, Joachim
name: McEachern, Steven
Publisher: name: Zenodo
Year: 2019
Subjects: DDI4
metadata
cross-domain research data

description: The DDI Alliance released a prototype of DDI 4. DDI 4 is a large UML model library for describing research and other data. Subsets of the library--called views--are provided for specific user perspectives. Encodings in other technologies, XML Schema and OWL/RDF, are available as well.

 DDI 4 has potential as a metadata standard for cross-domain research data. Large parts of DDI 4 are independent from the social science domain. Especially in the areas of data description, conceptual, and workflows (for process description), DDI 4 will be useful for a cross-domain approach. The DDI 4 data description is based on two powerful techniques: first, the datum-based approach which enables the description of data in many forms (also data lakes and legacy forms); second, the variable cascade which links conceptual definitions down to the instance variable.

 The presentation will focus on the above mentioned features in the context of cross-domain use cases, and will describe the current status of DDI 4 development after a public review of the DDI 4 prototype release.
Investigation of a short argon arc with hot anode. Part I: numerical simulations of non-equilibrium effects in the near-electrode regions
Creators: name: Khrabry, A.
name: Kaganovich, I.
name: Nemchinsky, V.
name: Khodak, A.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: Atmospheric pressure arcs have recently found application in the production of nanoparticles. Distinguishing features of such arcs are small length and hot ablating anode characterized by intensive electron emission and radiation from its surface. We performed one-dimensional modeling of argon arc, which shows that near-electrode effects of thermal and ionization non-equilibrium play important role in operation of a short arc, because the non-equilibrium regions are up to several millimeters long and are comparable with the arc length. The near-anode region is typically longer than the near-cathode region and its length depends more strongly on the current density. The model was extensively verified and validated against previous simulation results and experimental data. Volt-Ampere characteristic (VAC) of the near-anode region depends on the anode cooling mechanism. The anode voltage is negative. In case of strong anode cooling (water-cooled anode) when anode is cold, temperature and plasma density gradients increase with current density resulting in decrease of the anode voltage (absolute value increases). Falling VAC of the near-anode region suggests the arc constriction near the anode. Without anode cooling, the anode temperature increases significantly with current density, leading to drastic increase in the thermionic emission current from the anode. Correspondingly, the anode voltage increases to suppress the emission - and the opposite trend in the VAC is observed. The results of simulations were found to be independent of sheath model used: collisional (fluid) or collisionless model gave the same plasma profiles for both near-anode and near-cathode regions.
description: 29 pages, 16 figures
Extended Data - Impact of daily, oral pre-exposure prophylaxis on the risk of bacterial sexually transmitted infections among cisgender women: a systematic review and narrative synthesis
Creators: name: Papageorgiou, Vasiliki
name: Crittendon, Erica
name: Coukan, Flavien
name: Davies, Bethan
name: Ward, Helen
Publisher: name: Zenodo
Year: 2022
Subjects: pre-exposure prophylaxis
bacterial sexually transmitted infections
cisgender women
HIV prevention

description: Extended data for a systematic review on the impact of pre-exposure prophylaxis (PrEP) on the risk of bacterial sexually transmitted infections (STIs) among cisgender women which includes: Additional File 1 - PRISMA 2020 checklist Additional File 2 - Systematic review protocol Additional File 3 - PICO criteria Additional File 4 - Search strategy Additional File 5 - Standardised extraction template Additional File 6 - GRADE assessment of included studies
Determination of quinolone residues in raw cow milk. Application of polar stir-bars and ultra-high performance liquid chromatography–tandem mass spectrometry
Creators: name: Rodríguez-Gómez, Rocío
name: García-Córcoles, María Teresa
name: Morsina Çipa
name: Barrón, Dolores
name: Navalón, Alberto
name: Zafra-Gómez, Alberto
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified

description: Seventeen quinolone antibiotics were determined in cows’ milk. A method of high sensitivity, selectivity and accuracy was developed. Accuracy (trueness and precision), linearity, sensitivity, selectivity, decision limit and detection capability were established following the recommendations of the Commission Decision 2002/657/EC and the Food and Drug Administration (FDA) guideline. The use of polar stir-bar sorptive extraction (SBSE) prior to UHPLC-MS/MS analysis is proposed. The variables that affect SBSE were optimised using multivariate optimisation strategies. The ionic strength, the extraction time and the sample volume were studied. pH and stir-bar coating (polydimethylsiloxane, PDMS, and polyethyleneglycol modified silicone, PEG) were studied. PEG showed the best extraction yield at pH 6. For validation, a matrix-matched calibration and a recovery assay were carried out. Limits of quantification from 0.5 μg kg−1 for nalidixic acid, flumequine and piromidic acid, to 4.0 μg kg−1 for sarafloxacin were calculated. The precision (%, RSD) was lower than 15% for all antibiotics. Recoveries in fortified samples were between 88 and 114%.
Accelerating Innovation: Leveraging Cloud Services to Drive AI Adoption and Use
Creators: name: Vanichkina, Darya
Publisher: name: Zenodo
Year: 2024
Subjects: Machine Learning
Analytics
Other
Tools
Deep Learning
Infrastructure
Data
AI
Strategy
cloud; computing

description: Harnessing cutting-edge AI, machine learning, and data-driven research often involves leveraging cloud computing platforms. This BoF session will feature a panel of speakers who will showcase how using the AI-related services provided by Amazon Web Services (AWS), Microsoft Azure, and Google Cloud Platform (GCP) have led to research insights and discoveries at our institutions, after which the discussion will be opened to the floor.

This BoF will expose attendees to the benefits and challenges such use offers, including streamlined publication processes, extended computational resources, upskilling opportunities, as well as privacy, security, cost and reproducibility conundrums. The session will explore real-world case studies, showcasing how researchers across diverse disciplines have leveraged these technologies to accelerate their work, drive innovation, and contribute to the advancement of human knowledge.

The aim of this panel discussion is for attendees, including researchers, data scientists, software engineers, and professionals supporting research at academic, government, and not-for-profit organisations, to walk away with ideas and strategies for getting the most out of the smorgasbord that cloud providers offer.
Additional file 1 of HIMA2: high-dimensional mediation analysis and its application in epigenome-wide DNA methylation data
Creators: name: Perera, Chamila
name: Zhang, Haixiang
name: Zheng, Yinan
name: Hou, Lifang
name: Qu, Annie
name: Zheng, Cheng
name: Xie, Ke
name: Liu, Lei
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Additional file 1. Table S1: Bias (MSE) for mediation effect estimates. Table S2: FDR at significance level 0.05. Table S3: Power at significance level 0.05.
title: ADCO, Cartulaire du prieuré Notre-Dame de Bonvaux, dépendant du Val-des-Ecoliers (XVe siècle), Dijon, Cart. 228 (27 H), 68 folios, 109 actes (1211-1356), f. 0095
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2011
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi

description: Cartulaire du prieuré Notre-Dame de Bonvaux, dépendant du Val-des-Ecoliers (XVe siècle), Dijon, Archives départementales de la Côte-d'Or, Cart. 228 (27 H), 68 folios, 109 actes (1211-1356). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire du prieuré Notre-Dame de Bonvaux, dépendant du Val-des-Ecoliers (XVe siècle), Dijon, Archives départementales de la Côte-d'Or, Cart. 228 (27 H), 68 folios, 109 actes (1211-1356), f. 0095, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb15250518p
description: Provenance: http://www.idref.fr/02643413X/id
description: Provenance: https://www.geonames.org/6453767
description: Provenance: Dijon
description: Provenance: http://www.wikidata.org/entity/Q7003
Monte Carlo study of the Coincidence Resolving Time of a liquid xenon PET scanner, using Cherenkov radiation
Creators: name: Gomez-Cadenas, Juan Jose
name: Benlloch-Rodríguez, José María
name: Ferrario, Paola
Publisher: name: arXiv
Year: 2017
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Medical Physics (physics.med-ph)
subject: FOS: Physical sciences

description: In this paper we use detailed Monte Carlo simulations to demonstrate that liquid xenon (LXe) can be used to build a Cherenkov-based TOF-PET, with an intrinsic coincidence resolving time (CRT) in the vicinity of 10 ps. This extraordinary performance is due to three facts: a) the abundant emission of Cherenkov photons by liquid xenon; b) the fact that LXe is transparent to Cherenkov light; and c) the fact that the fastest photons in LXe have wavelengths higher than 300 nm, therefore making it possible to separate the detection of scintillation and Cherenkov light. The CRT in a Cherenkov LXe TOF-PET detector is, therefore, dominated by the resolution (time jitter) introduced by the photosensors and the electronics. However, we show that for sufficiently fast photosensors (e.g, an overall 40 ps jitter, which can be achieved by current micro-channel plate photomultipliers) the overall CRT varies between 30 and 55 ps, depending of the detection efficiency. This is still one order of magnitude better than commercial CRT devices and improves by a factor 3 the best CRT obtained with small laboratory prototypes.
description: accepted by JINST
Development of an ultrasensitive PCR assay for polycyclic musk determination in fish
Creators: name: Xiaohan Zhang
name: Huisheng Zhuang
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Polycyclic musks (PCMs) in the aquatic environment and organisms have become an emerging environmental issue because of their potential risk. The most used method for polycyclic musk determination is gas chromatography-mass spectrometry (GC-MS) with different sample extractions, which are somewhat expensive to operate, complex and laborious. In this study, a novel and ultrasensitive real-time polymerase chain reaction (PCR) assay with multiple signal amplification of carboxylic-DNA by gold nanoparticle-polyamidoamine conjugation (Au-PAMAM) was developed for determining polycyclic musks in fish. Hapten and immunogen were specially prepared. Polyclonal antibodies were produced based on the optimal immunisation, and the antibodies were characterised. Due to PAMAM’s unique nanostructure of numerous functional amino groups, polyclonal antibody and carboxylic-DNA were immobilised by Au-PAMAM conjugation to develop the antibody-Au-PAMAM-DNA probes, which were used as a signal DNA amplifier in the PCR system. Compared with real-time immuno-PCR, this biological probe-amplified immuno-PCR (BPAI-PCR) assay had higher sensitivity due to the probes’ higher ratio of signal DNA. Finally, the BPAI-PCR assay was applied to analyse AHTN (7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene,Tonalide) concentrations in fish samples in the range from 1 pg/L to 10 ng/L, giving an of LOD 0.61 pg/L. In general, due to the specificity of the antibody and novel nanoprobe design, this BPAI-PCR assay provided a potential way for trace analysis of AHTN in the aquatic organisms. The high concentrations of AHTN found in cultivated fish should encourage further toxicological studies.
A Techno-Economic MILP Optimization of Multiple Offshore Wind Concessions
Creators: name: Hardy, Stephen
name: Van Brusselen, Kristof
name: Van Hertem, Dirk
name: Ergun, Hakan
Publisher: name: Zenodo
Year: 2020
Subjects: Optimization, Offshore, Wind, MILP, Transmisison

description: Within this work, a techno-economic optimization of large offshore wind regions, consisting of multiple concessions is developed and investigated. Currently, the practice within the European offshore wind industry is for countries to designate an offshore wind power zone within their exclusive economic area (EEA). This zone is then further divided into individual concessions which are auctioned off to developers. Developers then optimize each individual concession independently. As such, research on electrical system optimization has been heavily focused at the scale of the individual concession, ignoring the possible gains that come from current or future developments in neighboring concessions within the same region [1]. It is believed that there is a significant opportunity for both cost savings and increased system reliability by optimizing an entire offshore wind zone prior to the development of each individual concession [2]. This work attempts to investigate these opportunities.
 The techno-economic optimization is formulated as a mixed integer linear program (MILP). Typical voltage levels for HVAC and HVDC transmission are included as well as mid-point reactive power compensated HVAC transmission. Mid-point compensation has been shown to extend the economic range of HVAC systems [3]. The optimization finds a global minimum for the lifetime cost of energy. To guarantee the feasibility of the results, a full “AC” analysis of the proposed technical design is performed. The lifetime costs accounted for are capital expenditures (CAPEX) related to material and labor during the construction phase, operating expenditures (OPEX) related to plant maintenance and operation, and the Expected Energy Not Served (EENS). The use of site-specific wind profiles and turbine specific power curves make for geographically and technologically relevant solutions.
 To quantify the possible benefits of optimizing an entire region, a case study within the Belgian North-sea is investigated. The offshore wind zone within the Belgian EEA consists of 10 concessions all at varying degrees of development. The zone spans an area of 175 km2 and will have a total capacity, once fully developed, exceeding 2.2GW [4]. The optimal solution is compared to the existing solution in order to extract the areas in which improvement can be made using the proposed optimization method.