cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Improvements to multiple overlapping thin slab three-dimensional acquisition magnetic resonance angiography
Creators: name: Robison, Ronald Orie
Publisher: name: University of Utah
Year: 2012
Subjects: MRI Image Improvememen

description: This thesis project summarizes improvements that have been made to the multiple overlapping thin slab three-dimensional acquisition magnetic resonance angiography (MOTSA MRA) technique. The primary research hypothesis states that images of the cervical carotid artery obtained using the MOTSA MRA technique can be improved by 1) optimizing imaging parameters during acquisition, 2) processing overlapping slice information, and 3) reducing background signal from fat tissue.  Three parameters that affect quality during acquisition are flip angle (FA), repetition time (TR), and the slab excitation fraction (SEF).  Be increasing the slab excitation fraction from 07.75 to 1.10, the slab boundary artifact was reduced by 29-56% (p<0.0001).  The contrast-to-noise ratio (CNR) of the cervical catorid artery can be increased approximately sixfold (p<0.0001) by increasing the flip angle from 10° to 50°.  The effect of the repetition time on image quality was not statistically significant for the range studied (52-70ms).  To determine the utility of processing overlapping slice information, a study measuring the slab boundary artifact (V/P SNR) both with and without utilization of overlapping slice information was performed.  For the three imaging parameter combinations studies (FA=30°, TR=52ms, SEF=0.75; FA=30°, TR=52ms, SF=1.10; FA=50°, TR=52ms, SEF=1.10), the V/P SNRs without utilizing overlapping slice information was 0.74, 0.86, and 0.83 respectively.  Following postprocessing of the overlapping information, the V/P SNRs improved to 0.86, 0.91, and 0.93 respectively.  This represents an average improvement of 46% of the slab boundary artifact.  To reduce the background signal from fat tissue surrounding the carotid artery bifurcation, the 1331 fat saturation pulse was implemented into the MOTSA MRA pulse sequence.  The saturation pulse flip angel (SPFA) and interpulse delay (tau) were studied to identify the values that produce the best vessel visibility.  The optimal values for the SPFA and tau were 60° (7.5°,-22.5°, 22.5°, -7.5°) and 2.0-3.0ms respectively.   AT these values there was a 1.56-fold increase (SD=±0.12, p<0.01) in the CNR between the left internal carotid artery and fat compared to the study without fat saturation.  A threefold increase was noted for the smaller left occipital artery.  In can be concluded that the slab boundary artifact of the MOTSA MRA technique can be reduced significantly by optimizing imaging acquisition parameters and processing overlapping slice information.  The cervical carotid artery visibility can be significantly improved by optimizing imaging parameters and reducing background signal from fat tissue.
Burschen d. Paedagogia W/S 1887/1888
Creators: name: Várady, Adam Borbély
Publisher: name: [s.n.]
Year: 1887
Subjects: Porträtfotografie
Meyer, Heinrich1870-1930
Mähly, Otto1869-1953

description: Gruppenporträt der Burschen der Pädagogia Basel im Wintersemester 1887/1888
description: A. Varady
description: Abzug auf eine Kabinettkarte montiert
description: Titel, Datierung sowie Namen der abgelichteten Personen gemäss handschriftlicher Notiz auf der Rückseite der Kabinettkarte
description: Namen der abgelichteten Personen (hintere Reihe, von links nach rechts):Wilhelm Brückner v/o Motsch, Heinrich Meyer v/o Storch, Fritz Fichter v/o Ex, August Vögelin v/o Steiz, Fritz Metzger v/o Müll; (untere Reihe, von links nach rechts) Otto Maehly v/o Klotz, Alfred Wieland v/o Rollmops
Cyclocephala lunulata Burmeister 1847
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala lunulata

description: Cyclocephala lunulata Burmeister, 1847
Cyclocephala lunulata Burmeister 1847: 62 (Brazil)
Distribution. Guyana: Bodkin 1919: 215; Endrödi 1966a: 242; Moore et al. 2018b: 201. Suriname: MHCN - NEW COUNTRY RECORD (Suriname, Saramacca, Groningen, Plantage Misgunst, (5°46′20″N, 55°29′00″W). 4/ 6-IX-2015. M. A. Hielkema. On HPL.). French Guiana: Endrödi 1966a: 242; Duranton 2011: 13; Ponchel 2011: 60; Dupuis 2016b: 109; Moore et al. 2018b: 201. Brazil: Burmeister 1847: 62; Blackwelder 1944: 252; Endrödi 1966a: 242; Moore et al. 2018b: 201. Venezuela: Endrödi 1966a: 242; Moore et al. 2018b: 201. Other: Arrow 1937b: 12 (Mexico, South America); Blackwelder 1944: 252 (Argentina, Belize, Costa Rica, Guatemala, Mexico, Nicaragua, Panama); Endrödi 1966a: 242 (Argentina, Bolivia, Colombia, Costa Rica, Ecuador, El Salvador, Guatemala, Honduras, Mexico, Nicaragua, Panama, Paraguay, Peru, Trinidad and Tobago, U.S.A.), 1985a: 97, 138 (Argentina–U.S.A.); Lachaume 1992: 15 (Argentina–U.S.A.); Ratcliffe 2003: 148 (Argentina/Paraguay–Mexico); Moore et al. 2018b: 201 (Argentina, Belize, Bolivia, Colombia, Costa Rica, Ecuador, El Salvador, Guatemala, Honduras, Mexico, Nicaragua, Panama, Paraguay, Peru, Trinidad and Tobago, U.S.A.).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 172, DOI: 10.5281/zenodo.3678492
Selective inhibition of carbonic anhydrase IX and XII by coumarin and psoralen derivatives
Creators: name: Meleddu, Rita
name: Deplano, Serenella
name: Maccioni, Elias
name: Ortuso, Francesco
name: Cottiglia, Filippo
name: Secci, Daniela
name: Onali, Alessia
name: Sanna, Erica
name: Angeli, Andrea
name: Angius, Rossella
name: Alcaro, Stefano
name: Supuran, Claudiu T.
name: Distinto, Simona
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: A small library of coumarin and their psoralen analogues EMAC10157a-b-d-g and EMAC10160a-b-d-g has been designed and synthesised to investigate the effect of structural modifications on their inhibition ability and selectivity profile towards carbonic anhydrase isoforms I, II, IX, and XII. None of the new compounds exhibited activity towards hCA I and II isozymes. Conversely, both coumarin and psoralen derivatives were active against tumour associated isoforms IX and XII in the low micromolar or nanomolar range of concentration. These data further corroborate our previous findings on analogous derivatives, confirming that both coumarins and psoralens are interesting scaffolds for the design of isozyme selective hCA inhibitors.
Channel capacity, signaling design, and statistical detection for multiple-antenna channels
Creators: name: Wan, Hong
Publisher: name: University of Utah
Year: 2012
Subjects: Detection
Equalization
MCMC
MIMO
Multiuser
Channel capacity
Signaling design

description: This dissertation addresses several key challenges in multiple-antenna communications, including information-theoretical analysis of channel capacity, capacity-achieving signaling design, and practical statistical detection algorithms.  The first part of the thesis studies the capacity limits of multiple-input multiple-output (MIMO) multiple access channel (MAC) via virtual representation (VR)  model. The VR model captures the physical scattering environment via channel gains in the angular domain, and hence is a realistic MIMO channel model that  includes many existing channel models as special cases. This study provides analytical characterization of the optimal input distribution that achieves the sum-capacity of MAC-VR. It also investigates the optimality of beamforming, which is a simple scalar coding strategy desirable in practice. For temporally correlated channels, beamforming codebook designs are proposed that can efficiently exploit channel correlation.  The second part of the thesis focuses on statistical detection for time-varying frequency-selective channels. The proposed statistical detectors are developed based  on Markov Chain Monte Carlo (MCMC) techniques. The complexity of such detectors grows linearly in system dimensions, which renders them applicable to inter-symbol-interference (ISI) channels with long delay spread, for which the traditional trellis-based detectors fail due to prohibitive complexity. The proposed MCMC detectors provide substantial gain over the de facto turbo minimum-mean square-error (MMSE) detector for both synthetic channel and underwater acoustic (UWA) channels. The effectiveness of the proposed MCMC detectors is successfully validated through experimental  data collected from naval at-sea experiments.
Charles Perrochet s/l Taig
Creators: name: Taeschler-Signer, Carl
Publisher: name: [s.n.]
Year: 1882
Subjects: Porträtfotografie

description: Burstbild von Charles Perrochet zusammen mit einem Farbenbruder.
description: Taeschler, Photogr.
description: Titel gemäss handschriftlicher Widmung auf der Rückseite der Kabinettkarte
description: Abzug auf eine Kabinettkarte montiert
Small molecule inhibitors of cyclin-dependent kinase 9 for cancer therapy
Creators: name: Alsfouk, Aisha
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Cyclin-dependent kinase 9 (CDK9) plays a vital role in transcription through regulation of short-lived anti-apoptotic genes required for cancer cell survival. Therefore, targeting CDK9 with small molecule inhibitors has emerged as a potential cancer therapy. This article reviews the most recent CDK9 patent literature (2012–2020) related to small molecule inhibitors in cancer along with their selectivity profile and biological results in preclinical studies.
A. Hoffmann stud. med. s/l A Sulger stud. iur. z. fr. Er
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1875
Subjects: Porträtfotografie
Sulger, August1856-1922
Hoffmann, Albert1856-1924
Kündig, Rudolf1857-1923

description: Gruppenporträt der farbentragenden Studenten (von links nach rechts) Rudolf Kündig-Koechlin, Albert Hoffmann-Paravicini und August Sulger
description: J. Jungmann
description: Abzug auf Kabinettkarte montiert
description: Titel und Datierung gemäss handschriftlicher Notiz auf der Rückseite der Kabinettkarte
SSI: Distributed Workflow Management Research and Software in Support of Science
Creators: name: Deelman, Ewa
name: Vahi, Karan
name: Rynge, Mats
name: Mayani, Rajiv
name: Papadimitriou, George
name: Jain, Aditi
name: Livny, Miron
name: Bollig, Cole
Publisher: name: Zenodo
Year: 2022
Subjects: Pegasus, workflow management system, CSSI

description: This is a poster about the Pegasus Workflow Management System presented at the 2022 NSF Cyberinfrastructure for Sustained Scientific Innovation (CSSI) Principal Investigator meeting.
description: Pegasus WMS is funded by the National Science Foundation CSSI program grant #1664162
Zuggi und Spatz i/l Guzzi z. fr. Er
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1875
Subjects: Porträtfotografie
Merian, Rudolf1856-1921

description: Die farbentragenden Studenten Rudolf Merian und Alexander Bourcart (von links nach rechts)
description: J. Jungmann
description: Abzug auf eine Kabinettkarte montiert
description: Titel und Datierung gemäss handschriftlicher Widmung auf der Rückseite der Kabinettkarte
Mapping, cloning and characterization of the mass1 gene in Frings audiogenic seizure-susceptible mice
Creators: name: Skradski, Shana
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Frings audiogenic seizure-susceptible mice are a model for sensory-evoked reflex seizures.  Their seizure phenotype is characterized by wild running, loss of righting reflex, tonic flexion, and tonic extension in response to high intensity sound stimulation.  The present study determined that the mode of inheritance for audiogenic seizure-susceptibility in Frings mice is due to the autosomal recessive inheritance of a single gene.  This gene locus was named mass1 for monogenic audiogenic seizure susceptible and was mapped by linkage analysis to the middle region of chromosome 13.  further genetic mapping refined the nonrecombinant interval to a distant of approximately 80 kilobases, and a dense physical map spanning the region was developed.  Analysis of genomic sequence from the region identified a single novel gene.  Within this gene, a single base pair deletion was detected exclusively in Frings mouse DNA, which produces a truncated protein in vitro.  The conclusion from these data is that the novel gene is mass1 and the protein truncation is associated with Frings mouse audiogenic seizures.  Characterization of mass1 show that is a larger gene multiple exons that encodes three putative alternate transcripts.  Expression of mass1 was detected in brain, lung, and kidney.  To predict the function of mass1 protein (MASS1), we analyzed the amino acid sequence for homology to known proteins and found significant matches with a cytosolic loop region of the sodium+/calcium2+ exchanger protein family.  This homology is due to a repetitive domain within MADD1.  MASS1 also contains a multicopper oxidase consensus sequence that is located near the COOH terminus of the protein and would be missing in Frings mutant MASS1 protein.  This motif is an important putative domain that will be characterized to determine if it is functional in MASS1.  Further study of the MASS1 protein will elucidate its exact function in cells, particularly neurons, which will ultimately determine the role of the wild type protein, and how the Frings mutant MASS1 leads to audiogenic seizure-susceptibility.  Understanding the function of this protein and its role in neuronal excitability may provide novel targets for anticonvulsant agent leading to new therapies for the treatment of epilepsy.
Cyclocephala macrophylla Erichson 1847
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala macrophylla

description: Cyclocephala macrophylla Erichson, 1847
Cyclocephala macrophylla Erichson 1847: 97 (Peru - LECTOTYPE)
Distribution. Guyana: Endrödi 1966a: 245, 1985a: 101, 147; Moore et al. 2018b: 205. Other: Erichson 1847: 97 (Peru); Arrow 1937b: 12 (Peru); Blackwelder 1944: 252 (Peru); Endrödi 1966a: 245 (Bolivia, Costa Rica, Ecuador, Guadeloupe, Peru - designation LECTOTYPE Cyclocephala macrophylla), 1985a: 101, 147 (Bolivia, Costa Rica, Ecuador, Peru, Antilles); Ratcliffe 2003: 151 (Bolivia–Costa Rica); Moore et al. 2018b: 205 (Bolivia, Colombia, Costa Rica, Ecuador, Panama, Peru).
Note. Endrödi (1966a: 245) records Cyclocephala macrophylla for Guyana, which is repeated in Endrödi (1985a: 101, 147) and Moore et al. (2018b: 205). We are unaware of any other records of this species for the research area and consider its occurrence there doubtful and in need of confirmation.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 173, DOI: 10.5281/zenodo.3678492
CINES: A Scalable CyberInfrastructure for Sustained Innovation in Network Engineering and Science
Creators: name: Marathe, Madhav V.
name: Kuhlman, Chris
name: Machi, Dustin
name: Ravi, S. S.
Publisher: name: Zenodo
Year: 2022

description: This is the poster for the NSF project "CINES: A Scalable CyberInfrastructure for Sustained Innovation in Network Engineering and Science" Award OAC 1916805 University of Virginia
description: NSF Award OAC 1916805
[4 Silhouetten mit den Konterfeis der Studenten Aimé Herminjard, Karl Sartorius, Jules Duperrex und Karl Felix Burckhardt]
Creators: name: Lichtdruckanstalt Alfred Ditisheim
Publisher: name: Lichtdruckanstalt Alfred Ditisheim
Year: 1850
Subjects: Porträtfotografie

description: Unbekannte/r Künstler/in
Familie Hagenbach-Merian
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1899
Subjects: Porträtfotografie
Hagenbach, Friedrich1840-1913
Hagenbach-Merian, Friedrich1804-1900
Hagenbach-Berri, Julie1843-1927

description: Grupppenfoto der Familie Hagenbach-Merian (von links nach rechts): Friedrich Hagenbach (1840-1913), Julie Berri (1813-1927), Friedrich Hagenbach (1804-1900) und eine unbekannte Person
description: Hans Lindorff fecit
description: Abzug auf einen Karton montiert
description: Titel und Datierung gemäss handschriftlicher Notiz auf der Rückseite des Kartons
description: Im rechten Hintergrund wurde eine Person retuschiert
Liberation-limited grade/recovery curves for auriferous pyrite ores as determined by high resolution x-ray microtomography
Creators: name: Medina, Juan Francisco
Publisher: name: University of Utah
Year: 2012
Subjects: Grade/recovery
Liberation
Microtomography
Auriferous pyrite ores

description: As in all flotation separations, the separation efficiency for the flotation of pyrite from auriferous pyrite ores depends on the flotation conditions and the particle properties of the feed ore. Liberation and texture are particle properties that refer to release of valuable minerals from gangue waste minerals during size reduction and the arrangement of these mineral phases within the particles. Separation efficiency may be impacted significantly by variation in liberation and the texture of locked particles, even with locked particles having the same overall composition. Not all locked particles of the same composition will have the same flotation response. Their flotation response will also depend on their texture. Now, analysis of liberation and texture is possible using High Resolution X-ray Microtomography (HRXMT). This analytical technique can provide quantitative information on liberation and exposure (texture) for each particle in a given particle population. Products from the flotation of two types of auriferous pyrite ores, both batch scale experiments and plant operations, were analyzed by HRXMT. In this way, the degree of liberation of the pyrite grains was determined. The liberation-limited grade/recovery curves were calculated for each ore. The liberation-limited grade/recovery curves are used to determine the limits of the separation efficiency. Also, the characteristic texture of particles in each flotation product was determined and the effect of these textural features on the flotation separation efficiency discussed. It was found that the separation efficiency of auriferous pyrite was controlled principally by factors other than liberation. In general the texture analysis revealed that the pyrite-containing particles with a high exposure of pyrite grains at the particle surface have a better possibility of being recovered in the concentrate during flotation.
An investigation of 1,4-dicyanotetrazine as a building block in molecule-based magnetic materials
Creators: name: Vo, Hoa-Lan
Publisher: name: University of Utah
Year: 2012
Subjects: Molecule-based magnetic materials
1,4-dicyanotetrazine

description: Organic ligands are important components in molecule-based magnets, as they allow for control over the physical and magnetic properties. Spin-carrying radical organic ligands, specifically, have been seen to enhance magnetic properties. Investigating reactions of 1,4-dicyanotetrazine, DCNT, an organic ligand capable of being reduced to a radical anion (-0.033 V vs. SCE), with spin carrier and paramagnetic building-blocks such as decamethylferrocene, vanadium hexacarbonyl, and tetrakis(dimethylamino)-ethylene have led to mixed results. While the reaction of Fe(Cp*)2 with DCNT was expected to form 0-D chains of alternating [DCNT]•- and [FeCp*2]•+ that magnetically ordered, this was not the case as the room-temperature χT value of 0.222 emu K/mol was significantly lower than the calculated spin-only value of 0.75 emu K/mol for a system of two S = 1/2 ions. However, as the infrared spectrum indicates reduced DCNT, another bonding motif may be occurring that could include the dimerization or trimerization of DCNT. The structure of [FeCp*2][DCNT] has not been elucidated and further investigation is needed. Reaction of DCNT and V(CO)6 forms a black amorphous precipitate, similar to V[TCNE]x. Infrared spectra indicate reduced DCNT; however, the magnet data are inconclusive. TDAE and DCNT forms an electron transfer salt, in which DCNT is reduced and TDAE is oxidized to the 2+ charge. The magnetic data are also inconclusive.
Development of 2-oindolin-3-ylidene-indole-3-carbohydrazide derivatives as novel apoptotic and anti-proliferative agents towards colorectal cancer cells
Creators: name: Eldehna, Wagdy M.
name: Abo-Ashour, Mahmoud F.
name: Al-Warhi, Tarfah
name: Al-Rashood, Sara T.
name: Alharbi, Amal
name: Ayyad, Rezk R.
name: Al-Khayal, Khayal
name: Abdulla, Maha
name: Abdel-Aziz, Hatem A.
name: Ahmad, Rehan
name: El-Haggar, Radwan
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Mitochondrial anti-apoptotic Bcl2 and BclxL proteins, are overexpressed in multiple tumour types, and has been involved in the progression and survival of malignant cells. Therefore, inhibition of such proteins has become a validated and attractive target for anticancer drug discovery. In this manner, the present studies developed a series of novel isatin–indole conjugates (7a-j and 9a-e) as potential anticancer Bcl2 and BclxL inhibitors. The progression of the two examined colorectal cancer cell lines was significantly inhibited by all of the prepared compounds with IC50 ranges132–611 nM compared to IC50 = 4.6 µM for 5FU, against HT-29 and IC50 ranges 37–468 nM compared to IC50 = 1.5 µM for 5FU, against SW-620. Thereafter, compounds 7c and 7g were selected for further investigations. Interestingly, both compounds exhibited selective cytotoxicity against both cell lines with high safety to normal fibroblast (HFF-1). In addition, both compounds 7c and 7g induced apoptosis and inhibited Bcl2 and BclxL expression in a dose-dependent manner. Collectively, the high potency and selective cytotoxicity suggested that conjugates 7c and 7g could be a starting point for further optimisation to develop novel pro-apoptotic and antitumor agents towards colon cancer.
[Porträt der Anna Riggenbach-Oser zusammen mit Margaretha Altweg-Oser]
Creators: name: Höflinger, Jakob
Publisher: name: [s.n.]
Year: 1878
Subjects: Porträtfotografie
Riggenbach-Oser, Anna1852-1933

description: J. Höflinger
description: Mit einer handschriftlichen Widmung und Datierung auf der Rückseite der Kabinettkarte: "Meiner l. Freundin in freundschaftlicher Erinnerung an die zusammen verbrachten Tage des Sommers 1877. Anna Oser April 1878"
description: Abzug auf eine Kabinettkarte montiert
description: Datierung gemäss handschriftlicher Notiz auf der Rückseite der Aufnahme
description: Namen der abgelichteten Personen gemäss handschriftlicher Notiz auf der Rückseite der Kabinettkarte
Modeling of wax deposition in a crude oil carrying pipeline
Creators: name: Montalvo, Preston
Publisher: name: University of Utah
Year: 2012
Subjects: Deposition
Wax
Paraffin
Pipelines

description: The oil modeled in this thesis has a large amount of paraffin and must be transported from where it is extracted to a refinery over a distance that includes changes in elevation and temperature. This study investigated the deposition that would occur due to the paraffin in the oil. In this study the paraffin containing oil was mixed with a diluent in order to lower the wax appearance temperature (WAT) of the oil for one case. The second case involved mixing the paraffin containing oil with a light crude oil that did not contain a large amount of paraffins. The cases were modeled using the DepoWax module found in the commercially available software PVTsim, by Calsep International Consultants. Both of the cases were modeled in a pipeline, when the weather would be the coldest due to the ambient temperature being much lower than the WAT. The large temperature gradient in the pipeline to the outside air causes the temperature of the oil to drop below the WAT and pipeline pressure to be quite high. High Temperature Gas Chromatography (HTGC), viscosity measurements and Fourier Transform Infrared Spectroscopy (FTIR) were used to characterize the oil. The HTGC gave the carbon number distribution of the paraffin containing oil as well as the diluent. Viscosity measurements gave rheological values for the oil at different temperatures as well as different dilutions with the diluent. The FTIR was used to determine the wax appearance temperature (WAT). The measured values from the previous tests all were used as inputs to DepoWax to characterize the oil and the mixtures to be modeled in the pipeline.
Cyclocephala maculata Burmeister 1847
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala maculata

description: Cyclocephala maculata Burmeister, 1847
Cyclocephala maculata Burmeister 1847: 40 (French Guiana - LECTOTYPE)
= Cyclocephala hielkemaorum Ratcliffe 2008: 231 (French Guiana) - Ponchel 2010b: 172 (syn. nov.)
Distribution. Guyana: Moore et al. 2018b: 205. Suriname: MHCN - NEW COUNTRY RECORD (Suriname, Sipaliwini, Arapahu Resort, (3°27′N, 57°37.5′W). 14-III-2011. A. J. Hielkema. At night on inflorescence of climbing palm Desmoncus polyacanthus.); NZCS; RMNH. French Guiana: Burmeister 1847: 40; Endrödi 1966a: 364 (designation LECTOTYPE Cyclocephala maculata), 1985a: 157 (as Mimeoma maculata); Ratcliffe 2008: 231 (as Cyclocephala hielkemaorum); Ponchel 2010b: 172 (as Mimeoma maculata), 2011: 60 (as Mimeoma maculata); Brûlé et al. 2011a: 192 (as Mimeoma maculata), 2014: 182 (as Mimeoma maculata); Duranton 2011: 17 (as Mimeoma maculata); Dupuis 2016b: 109 (as Mimeoma maculata); Moore et al. 2018b: 205; MHCN; RMNH. “Guianas”: Arrow 1937b: 5 (as Mimeoma maculata); Blackwelder 1944: 250 (as Mimeoma maculata); Endrödi 1966a: 364 (as Mimeoma maculata). Brazil: Blackwelder 1944: 250 (as Mimeoma maculata); Endrödi 1966a: 364 (as Mimeoma maculata), 1985a: 157 (as Mimeoma maculata); Moore et al. 2018b: 205. “Amazon Basin”: Arrow 1937b: 5 (as Mimeoma maculata). Other: Endrödi 1966a: 364 (Colombia - as Mimeoma maculata), 1985a: 157 (Colombia - as Mimeoma maculata); Moore et al. 2018b: 205 (Colombia).
Note. The mentioning of Cyclocephala maculata for Guyana in Moore et al. (2018b: 205) is based on the record for “Guayana” in Endrödi (1966a: 364) (M. Moore, pers. comm. 2018), which is omitted in Endrödi (1985a: 157). Although this species may well be present in Guyana, we consider its occurrence there in need of confirmation.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 173, DOI: 10.5281/zenodo.3678492
Development and characterisation of SMURF2-targeting modifiers
Creators: name: Ayyathan, Dhanoop Manikoth
name: Levy-Cohen, Gal
name: Shubely, Moran
name: Boutros-Suleiman, Sandy
name: Lepechkin-Zilbermintz, Veronica
name: Shokhen, Michael
name: Albeck, Amnon
name: Gruzman, Arie
name: Blank, Michael
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer

description: The C2-WW-HECT-domain E3 ubiquitin ligase SMURF2 emerges as an important regulator of diverse cellular processes. To date, SMURF2-specific modulators were not developed. Here, we generated and investigated a set of SMURF2-targeting synthetic peptides and peptidomimetics designed to stimulate SMURF2’s autoubiquitination and turnover via a disruption of the inhibitory intramolecular interaction between its C2 and HECT domains. The results revealed the effects of these molecules both in vitro and in cellulo at the nanomolar concentration range. Moreover, the data showed that targeting of SMURF2 with either these modifiers or SMURF2-specific shRNAs could accelerate cell growth in a cell-context-dependent manner. Intriguingly, a concomitant cell treatment with a selected SMURF2-targeting compound and the DNA-damaging drug etoposide markedly increased the cytotoxicity produced by this drug in growing cells. Altogether, these findings demonstrate that SMURF2 can be druggable through its self-destructive autoubiquitination, and inactivation of SMURF2 might be used to affect cell sensitivity to certain anticancer drugs.
Design and synthesis of novel quinazolinones conjugated ibuprofen, indole acetamide, or thioacetohydrazide as selective COX-2 inhibitors: anti-inflammatory, analgesic and anticancer activities
Creators: name: Sakr, Asmaa
name: Rezq, Samar
name: Ibrahim, Samy M.
name: Soliman, Eman
name: Baraka, Mohamed M.
name: Romero, Damian G.
name: Kothayer, Hend
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Novel quinazolinones conjugated with indole acetamide (4a–c), ibuprofen (7a–e), or thioacetohydrazide (13a,b, and 14a-d) were designed to increase COX-2 selectivity. The three synthesised series exhibited superior COX-2 selectivity compared with the previously reported quinazolinones and their NSAID analogue and had equipotent COX-2 selectivity as celecoxib. Compared with celecoxib, 4 b, 7c, and 13 b showed similar anti-inflammatory activity in vivo, while 13 b and 14a showed superior inhibition of the inflammatory mediator nitric oxide, and 7 showed greater antioxidant potential in macrophages cells. Moreover, all selected compounds showed improved analgesic activity and 13 b completely abolished the pain response. Additionally, compound 4a showed anticancer activity in tested cell lines HCT116, HT29, and HCA7. Docking results were consistent with COX-1/2 enzyme assay results. In silico studies suggest their high oral bioavailability. The overall findings for compounds (4a,b, 7c, 13 b, and 14c) support their potential role as anti-inflammatory agents.
Opiate receptor down-regulation and tolerance
Creators: name: Dean, Robin Rebecca
Publisher: name: University of Utah
Year: 2012
Subjects: Pharmacokinetics

description: The aim of the study was to investigate in the mouse the relationship between opiate-receptor down-regulation and opiate tolerance.  Animals were treated for variable periods of time either by daily i.p. administration of different doses of morphine for as long as 30 days or by pellet implantation with 75-mg morphine pellet for as long as 3 day.  Changes in morphine pharmacodynamics were assessed in two tests:  tailflick analgesia and hypothermia.  Receptor binding in specific brain structures was measured by the use of tritiated dihydromorphine and standard autoradiographic techniques. The results from the daily dose experiments indicate that in the anterior hypothalamus the periaqueductal grey and the paraventricular nucleus of the thalamus tolerance was invariably accompanied by down-regulation; however, there were treatment condition for which down-regulation occurred in the absence of tolerance, most notably, down-regulation was present without detectable tolerance after 2 days of treatment.  There were other instances in which the degree of down-regulation was not directly proportional to the degree of tolerance.  In addition, the maximum degree of down-regulation appeared limited to about 50 percent.  In the pellet experiments, receptor binding was measured in the dorsal raphe of spinal cord, as well as those areas in the daily dose experiments.  The results also illustrate that down-regulation occurs in certain instances, but the association between down-regulation and tolerance, and vice versa, is not as frequent as it is in the daily dose experiments.  Here again the maximum degree of down-regulation is limited to about 50 percent.  The data from both dosage regimes clearly demonstrate that exposure to morphine can cause opiate-receptor down-regulation; however, there appears to be no simple temporal or quantitative relationship between the down-regulation and tolerance to analgesia and hypothermia.
Cyclocephala marginalis Kirsch 1871
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala marginalis

description: Cyclocephala marginalis Kirsch, 1871
Cyclocephala marginalis Kirsch 1871: 356 (372) (Brazil)
Distribution. Guyana: Endrödi 1966a: 249, 1985a: 56, 131; Dechambre 1979c: 164; Moore et al. 2018b: 208. Suriname: MHCN - NEW COUNTRY RECORD (Suriname, Sipaliwini, Arapahu Resort, (3°27′N, 57°37.5′W). 12/ 15-III-2011. A. J. Hielkema. On UV/HPL in open area.); NZCS; RMNH. French Guiana: Endrödi 1966a: 249, 1985a: 56, 131; Dechambre 1979c: 164; Brûlé et al. 2011a: 191, 2014: 181; Duranton 2011: 13; Ponchel 2011: 60; Dupuis 2016b: 109; Moore et al. 2018b: 208; MHCN. Brazil: Kirsch 1871: 356 (372); Arrow 1937b: 12; Blackwelder 1944: 252; Endrödi 1966a: 249; Endrödi 1985a: 56, 131; Dechambre 1979c: 164; Moore et al. 2018b: 208. Other: Endrödi 1966a: 249 (Bolivia); Endrödi 1985a: 56, 131 (Bolivia); Dechambre 1979c: 164 (Bolivia); Moore et al. 2018b: 208 (Bolivia, Colombia, Peru).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 173, DOI: 10.5281/zenodo.3678492
Wildland firefighter entrapment avoidance: developing evacuation trigger points utilizing the wildland urban interface evacuation (WUIVAC) fire spread model
Creators: name: Fryer, Gregory K.
Publisher: name: University of Utah
Year: 2012
Subjects: Wildfire entrapment
Firefighter entrapment
Evacuation trigger points
FlamMap
GIS
Wildfire spread modeling
Wildland fire
Wildland urban interface evacuation

description: Wildland firefighters are often called on to make tactical decisions under stressful conditions in order to suppress a fire. They frequently make these decisions based on their gained intuition over time, and also by considering previous specific fire experiences. This assists them in anticipating future fire behavior and developing tactics designed to suppress the fire while avoiding entrapment. These decisions can be hindered by human factors such as insufficient knowledge of surroundings and conditions, inexperience, overextension of resources, or loss of situational awareness. One potential tool for assisting fire managers in situations where human factors can hinder decision-making is the Wildland Urban Interface Evacuation (WUIVAC) model, which models minimum fire travel times to create geographic triggers for evacuation  recommendations. Using a range of expected weather conditions and resource configurations, we generated a range of expected trigger buffer outcomes. Our objective was to use these outcomes to illustrate: (a) what spatial uncertainty is inherent in the geographic triggers produced by the range in expected conditions that contribute to fire behavior, and (b) after taking into account uncertainty, whether triggers are likely to be useful for rapid tactical decision-making. Utilizing 80 different tactical, weather, and fuel condition inputs, we demonstrated the use of WUIVAC for setting trigger points intended for use in planned firefighting operations to ensure entrapment avoidance. These triggers were used to determine when firefighting resources should disengage the fire and evacuate to a safety zone, shelter in place, turn down an assignment, or reengage and change tactics altogether based on predicted conditions. Using the 2007 Zaca Fire in the Los Padres National Forest, California as a case study, we show that WUIVAC can provide analytically driven physicallybased trigger points, and when coupled with intuitive decisions, it can assist in setting triggers for entrapment avoidance and ultimately contribute to firefighter safety.
Her und Frau Lüscher-Streckeisen
Creators: name: Taeschler-Signer, Carl
Publisher: name: [s.n.]
Year: 1880
Subjects: Porträtfotografie
Lüscher-Streckeisen, Carl1847-1911
Lüscher-Streckeisen, Helene1855-1924

description: Porträt des Ehepaars Carl und Helene Lüscher-Streckeisen
description: Taeschler, Photogr.
description: Abzug auf eine Kabinettkarte motiert
description: Titel gemäss handschriftlicher Notiz auf der Rückseite der Kabinettkarte
Strategy to enhance the father-infant relationship
Creators: name: Morkal, Colleen Carey
Publisher: name: University of Utah
Year: 2012

description: The purpose of this study was to identify the effect of a paternal orientation to newborn care and newborn behaviors on subsequent paternal attachment and caretaking behaviors.   Sixty-five subjects were randomly assigned to a treatment of a control group.  Fathers in the treatment group were shown a film about father-newborn interaction, given a demonstration about infant caregiving tasks and the opportunity to practice these tasks, and shown the infants; ability to see, hear and track an object.  Results of the study indicated that the intervention was effective in producing significantly more positive attachment behaviors in experimental group fathers.  No significant differences were found with regard to participation in infant caretaking, play, and  sex-role attitudes.
[Porträt des Gustav Christ mit Bertha Louise Ehinger]
Creators: name: Hartmann, Friedrich
Publisher: name: [s.n.]
Year: 1860
Subjects: Porträtfotografie
Christ, Gustav1836-1890
Christ-Ehinger, Bertha Luise1844-1924

description: F. Hartmann Maler und Photograph
description: Abzug auf eine Kabinettkarte montiert
description: Namen der abgelichteten Personen gemäss handschriftlicher Notiz auf der Rückseite der Kabinettkarte
D & C Heusler Christ 11 October 1884 Silberne Hochzeit
Creators: name: Taeschler-Signer, Carl
Publisher: name: [s.n.]
Year: 1884
Subjects: Porträtfotografie
Heusler-Christ, Daniel1830-1910
Heusler-Christ, Caroline1838-1907

description: Porträt des Daniel Heusler mit seiner Frau Caroline (geborene Christ) an ihrer silbernen Hochzeit
description: Taeschler, Photogr.
description: Abzug auf eine Kabinettkarte montiert
description: Titel und Datierung gemäss handschriftlicher Notiz auf der Rückseite der Kabinettkarte
Subject-specific modeling in computational cardiac electrophysiology
Creators: name: Swenson, Darrell
Publisher: name: University of Utah
Year: 2013
Subjects: Bidomain
Cardiac
Computational
Electrophysiology
Subject-specific modeling

description: Computational simulation has become an indispensable tool in the study of both basic mechanisms and pathophysiology of all forms of cardiac electrical activity. Because the heart is comprised of approximately 4 billion electrically active cells, it is not possible to geometrically model or computationally simulate each individual cell. As a result computational models of the heart are, of necessity, abstractions that approximate electrical behavior at the cell, tissue, and whole body level. The goal of this PhD dissertation was to evaluate several aspects of these abstractions by exploring a set of modeling approaches in the field of cardiac electrophysiology and to develop means to evaluate both the amplitude of these errors from a purely technical perspective as well as the impacts of those errors in terms of physiological parameters. The first project used subject specific models and experiments with acute myocardial ischemia to show that one common simplification used to model myocardial ischemia-the simplest form of the border zone between healthy and ischemic tissue-was not supported by the experimental results. We propose a alternative approximation of the border zone that better simulates the experimental results. The second study examined the impact of simplifications in geometric models on simulations of cardiac electrophysiology. Such models consist of a connected mesh of polygonal elements and must often capture complex external and internal boundaries. A conforming mesh contains elements that follow closely the shapes of boundaries; nonconforming meshes fit the boundaries only approximately and are easier to construct but their impact on simulation accuracy has, to our knowledge, remained unknown. We evaluated the impact of this simplification on a set of three different forms of bioelectric field simulations. The third project evaluated the impact of an additional geometric modeling error; positional uncertainty of the heart in simulations of the ECG. We applied a relatively novel and highly efficient statistical approach, the generalized Polynomial Chaos-Stochastic Collocation method (gPC-SC), to a boundary element formulation of the electrocardiographic forward problem to carry out the necessary comprehensive sensitivity analysis. We found variations large enough to mask or to mimic signs of ischemia in the ECG.
Anti-tubercular activity and molecular docking studies of indolizine derivatives targeting mycobacterial InhA enzyme
Creators: name: Venugopala, Katharigatta N.
name: Chandrashekharappa, Sandeep
name: Deb, Pran Kishore
name: Tratrat, Christophe
name: Pillay, Melendhran
name: Chopra, Deepak
name: Al-Shar’i, Nizar A.
name: Hourani, Wafa
name: Dahabiyeh, Lina A.
name: Borah, Pobitra
name: Nagdeve, Rahul D.
name: Nayak, Susanta K.
name: Padmashali, Basavaraj
name: Morsy, Mohamed A.
name: Aldhubiab, Bandar E.
name: Attimarad, Mahesh
name: Nair, Anroop B.
name: Sreeharsha, Nagaraja
name: Haroun, Michelyne
name: Shashikanth, Sheena
name: Mohanlall, Viresh
name: Mailavaram, Raghuprasad
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: A series of 1,2,3-trisubstituted indolizines (2a–2f, 3a–3d, and 4a–4c) were screened for in vitro whole-cell anti-tubercular activity against the susceptible H37Rv and multidrug-resistant (MDR) Mycobacterium tuberculosis (MTB) strains. Compounds 2b–2d, 3a–3d, and 4a–4c were active against the H37Rv-MTB strain with minimum inhibitory concentration (MIC) ranging from 4 to 32 µg/mL, whereas the indolizines 4a–4c, with ethyl ester group at the 4-position of the benzoyl ring also exhibited anti-MDR-MTB activity (MIC = 16–64 µg/mL). In silico docking study revealed the enoyl-acyl carrier protein reductase (InhA) and anthranilate phosphoribosyltransferase as potential molecular targets for the indolizines. The X-ray diffraction analysis of the compound 4b was also carried out. Further, a safety study (in silico and in vitro) demonstrated no toxicity for these compounds. Thus, the indolizines warrant further development and may represent a novel promising class of InhA inhibitors and multi-targeting agents to combat drug-sensitive and drug-resistant MTB strains.
System for computerized interactive protocols using H.E.L.P
Creators: name: Cannon, Scott Roy
Publisher: name: University of Utah
Year: 2012
Subjects: Rural Health
Medical Technologists

description: The expanded use of physicians' assistants could reduce the burden on ambulatory care physicians and increase the availability of health care to rural underserved areas. The acceptable use of assistants depends in part on the availability of appropriate support methods t insure the quality of care provided by these nonphysicians. The utilization of paper protocols--which define decision-making logic and provide data collection guidance for patient complaints--has been plagued with usage errors and problems of user alienation. The computerized interactive protocol system described in this dissertation represents a unqieu and workable solution to the problems of protocol implementation. Four prominent features enabled the system to provide effective support to physicians' assistants in tow clinical settings: 1. The HELP system of the Department of Medical Biophysics and Computing allowed flexible definitiona and easy modification of patient care protocols. 2. A thorough and specific evlauation of patient problems was insured by interactive computer prompting when data collection was inadequate. 3. Dependabel decisions were provided by computer execution of protocol logic and through data entry routines which resulted in about one error per 100 data entries. 4. The system provided a method of auditing care which was acceptable to physicians and assistants. Protocols for urinary tract infections, upper respiratory-ear, nose, and throat complaints, chronic diabetes, adn chronic hypertension were implemented on the system and utilized in the two clinical settings. Evaluation data from use of the upper respiratory0ear, nose, and throat protocol--involving 108 patient encounters--and the hypertension protocol--involving 145 retrospective chart audits--is presented. The upper respiratory-ear, nose, and throat protocol effectively managed 89 percent of patients whil the yypertension protocol managed 72 percent of patients without physician referrals. Both protocols demonstrated low error rates for false-positive and false-negative decisions. The automated self-histories provided with the computerized protocol system were demonstrated to be effective in collecting thorough histories relating to presenting complaints. As part of the conclusion section, a proposal is presented for the implementation of the protocol system on a small in-house minicomputer for use in rural clinics with physicians' assistant. Using a computerized interactive protocol system, protocols can be effectively implemented and provide adequate support to physicians' assistants. By insuring accurate decision-making and data collection for patient problems, assistants cn manage a large fraction of complaints normally directed to physicians and provide health care in many underserved areas.
Cyclocephala martinezi Endrodi 1964
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala martinezi

description: § Cyclocephala martinezi Endrödi, 1964
Cyclocephala martinezi Endrödi 1964: 456 (Venezuela)
Distribution. Venezuela (EO): Endrödi 1964: 456 (EO), 1966a: 251 (EO), 1985a: 90, 139; Moore et al. 2018b: 210 (EO). Other: Endrödi 1966a: 251 (Colombia), 1985a: 90, 139 (Colombia); Moore et al. 2018b: 210 (Colombia).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 174, DOI: 10.5281/zenodo.3678492