cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The impact of liraglutide on diabetes-related foot ulceration and associated complications in patients with type 2 diabetes at high risk for cardiovascular events: Results from the LEADER trial
Creators: name: Simpson, R.
name: Tarnow, L.
name: Tornøe, K.
name: Pratley, R.E.
name: Kaltoft, M.S.
name: Stellfeld, M.
name: Buse, J.B.
name: Dhatariya, K.
name: Bain, S.C.
Publisher: name: American Diabetes Association Inc.
Year: 2018

description: OBJECTIVE: Diabetes-related foot ulcers (DFUs) and their sequelae result in large patient and societal burdens. Long-term data determining the efficacy of individual glucose-lowering agents on DFUs are lacking. Using existing data from the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) trial, we conducted post hoc analyses assessing the impact of liraglutide versus placebo in people with type 2 diabetes and at high risk of cardiovascular (CV) events on the incidence of DFUs and their sequelae. RESEARCH DESIGN AND METHODS: The LEADER trial (NCT01179048) was a randomized, double-blind, multicenter, CV outcomes trial assessing liraglutide (1.8 mg/day) versus placebo, in addition to standard of care, for up to 5 years. Information on DFUs was collected systematically during the trial, and DFU complications were assessed post hoc through reviewing case narratives. RESULTS: During a median of 3.8 years' follow-up, similar proportions of patients reported at least one episode of DFU in the liraglutide and placebo groups (3.8% [176/4,668] versus 4.1% [191/4,672], respectively; hazard ratio [HR] 0.92 [95% CI 0.75, 1.13; P = 0.41]). Analysis of DFU-related complications demonstrated a significant reduction in amputations with liraglutide versus placebo (HR 0.65 [95% CI 0.45, 0.95; P = 0.03]). However, no differences were found for foot infections, involvement of underlying structures, or peripheral revascularization in the main analysis. CONCLUSIONS: Treatment with liraglutide in patients with type 2 diabetes and at high risk of CV events in the LEADER trial did not increase the risk of DFU events and was associated with a significantly lower risk of DFU-related amputations compared with placebo. This association, possibly due to chance, needs further investigation.
Accelerator measurements of magnetically-induced radio emission from particle cascades with applications to cosmic-ray air showers
Creators: name: Belov, K.
name: Mulrey, K.
name: Romero-Wolf, A.
name: Wissel, S. A.
name: Zilles, A.
name: Bechtol, K.
name: Borch, K.
name: Chen, P.
name: Clem, J.
name: Gorham, P. W.
name: Hast, C.
name: Huege, T.
name: Hyneman, R.
name: Jobe, K.
name: Kuwatani, K.
name: Lam, J.
name: Liu, T.
name: Nam, J.
name: Naudet, C.
name: Nichol, R.
name: Rauch, B. F.
name: Rotter, B.
name: Saltzberg, D.
name: Schoorlemmer, H.
name: Seckel, D.
name: Strutt, B.
name: Vieregg, A. G.
name: Williams, C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: For fifty years, cosmic-ray air showers have been detected by their radio emission. We present the first laboratory measurements that validate electrodynamics simulations used in air shower modeling. An experiment at SLAC provides a beam test of radio-frequency (RF) radiation from charged particle cascades in the presence of a magnetic field, a model system of a cosmic-ray air shower. This experiment provides a suite of controlled laboratory measurements to compare to particle-level simulations of RF emission, which are relied upon in ultra-high-energy cosmic-ray air shower detection. We compare simulations to data for intensity, linearity with magnetic field, angular distribution, polarization, and spectral content. In particular, we confirm modern predictions that the magnetically induced emission in a dielectric forms a cone that peaks at the Cherenkov angle and show that the simulations reproduce the data within systematic uncertainties.
description: 5 pages, 7 figures
title: Imaging of radial scars on Digital Breast Tomosynthesis: a pictorial review.
Creators: name: Zanelli, Elisa
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Breast
subject: Breast
subject: Mammography
subject: Ultrasound
subject: MR
subject: Diagnostic procedure
subject: Neoplasia
subject: Developmental disease

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Goals: 1) to illustrate the various patterns of presentations on digital breast tomosynthesis (DBT) of pathologically-proven radial scar (RS) without associated atypia; 2) to emphasize that benign RS can mimic invasive carcinoma on DBT images; 3) to...
(101367) Betsy Louisa Pepler
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
DENR Nutrient Management Plans--Supplemental Data Files
Creators: name: The University Of North Carolina At Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2019

description: Contains all the sprayfields for Duplin county only, lagoons for Duplin and Sampson counties only, and the corrected point location of the swine CAFO for Duplin county only. NC DENR has publicly available all point locations of swine CAFOs, but sometimes they are wrong. Provided here are correct point locations of the swine CAFO for Duplin county. Every sprayfield, lagoon, and point have the permit ID associated with them that can be used to link the three files together. NMPs require that each swine CAFO prove that there is enough acreage with enough crops to absorb the nutrients in the swine manure. The metric that NMPs use to figure out this balance is called "plant available nitrogen" abbreviated as PAN. The PAN sprayed onto fields from manure (PAN_spray) has to be less than the PAN that the crops can absorb (PAN_crops). The PAN_bal (balance) is the difference between the two. Attributes of the sprayfields include information on the PAN_spray, PAN_crop, and PAN_balance. Additionally, PAN_crop and PAN_balance was re-calculated using remote-sensing rather than what was reported in the NMP. As such there are PAN reported values as well as PAN calculated values at the sprayfield scale. Two sub-watershed shapefiles are included for Duplin county. These sub-watersheds are at the catchment scale and HUC12 scale. The catchment scale is smaller than the HUC12 scale. PAN metrics were aggregated at these sub-watershed scales. The sprayfield shapefile has attributes that identify the catchment and HUC12 that their centroid is in, however PAN metrics are calculated based on areal percent of sprayfield within each catchment/HUC12.
Incretin-based therapies and diabetic retinopathy: Real-world evidence in older U.S. adults
Creators: name: Wang, T.
name: Buse, J.B.
name: Hong, J.-L.
name: Pate, V.
name: Stürmer, T.
name: Gower, E.W.
name: Garg, S.
Publisher: name: American Diabetes Association Inc.
Year: 2018

description: OBJECTIVE: Recent large trials yield conflicting results on the association between incretin-based therapies (IBTs) and diabetic retinopathy (DR). We examined whether IBTs increase DR risk compared with other antihyperglycemics. RESEARCH DESIGN AND METHODS: We implementedan active comparator, new-user cohort design using anationwide 20% random sample of fee-for-service U.S. Medicare beneficiaries aged 65 years or older with Parts A, B, and D coverage between 2007 and 2015. We identified the following cohorts without prior treatment for retinopathy: dipeptidyl peptidase 4 inhibitors (DPP4i) versus sulfonylureas (SU), DPP4i versus thiazolidinediones (TZD), glucagon-like peptide-1receptor agonists (GLP1RA)versus long-acting insulin (LAI), and GLP1RA versus TZD. Primary outcome was advanced diabetic retinopathy requiring treatment (ADRRT), defined as a procedure code for retinopathy treatment. Incident diabetic retinopathy (IDR), identified by a diagnosis code, was a secondary outcome. We estimated propensity scores to balance confounders and adjusted hazard ratios (95% CI) using weighted Cox proportional hazards models. RESULTS: We identified 213, 652 eligible patients. During a median duration of 0.58 to 0.87 years across comparisons, with a rate from 6.0 to 12.8 per 1,000 person-years, IBTs were not associated with increased ADRRT or IDR risk. The adjusted hazard ratios (95% CI) for ADRRT were 0.91 (0.79-1.04) by comparing DPP4i to SU (n = 39,292 and 87,073); 0.91 (0.75-1.11), DPP4i to TZD (n = 51, 410 and 22, 231); 0.50 (0.39-0.65), GLP1RA to LAI (n = 9, 561 and 82, 849); and 0.75 (0.53-1.06), GLP1RA to TZD (n = 10, 355 and 27, 345). CONCLUSIONS: Our population-based cohort study of older U.S. adults with diabetes suggests that IBTs used for approximately 1 year do not increase the DR risk.
Characterization of the Martian atmosphere: global model comparison with NOMAD data
Creators: name: Galindo, Francisco González
name: Valverde, Miguel Ángel López
name: Brines, Adrián
name: Ashimananda Modak
name: Stolzenbach, Aurelien
name: Funke, Bernd
name: Moreno, José Juan López
name: Francois Forget
name: Ehouarn Millour
name: Lefévre, Franck
name: Vals, Margaux
name: Montmessin, Franck
name: Patel, Manish
name: Bellucci, Giancarlo
name: Ann-Carine Vandaele
Publisher: name: Zenodo
Year: 2022

description: Poster for the SEA 2022 meeting describing the comparison between ExoMars NOMAD solar occultation observations retrieved at the Instituto de Astrofísica de Andalucía and the predictions of a ground-to-exobase Global Climate Model. The temperature structure and the abundances of CO2, CO, and H2O in the mesosphere (up to ~100 km) are compared.
description: This work was supported by the Spanish Ministry of Science and Innovation, the Agencia Estatal de Investigación, and by the UE FEDER funds under grants RTI2018-100920-J-I00 and PGC2018-101836-BI00. The IAA/CSIC team acknowledges financial support from the State Agency for Research of the Spanish MCIU through the 'Center of Excellence Severo Ochoa' award for the Instituto de Astrofísica de Andalucía (SEV-2017-0709)
Sotagliflozin in combination with optimized insulin therapy in adults with type 1 diabetes: The North American in Tandem1 study
Creators: name: Bailey, T.S.
name: Sawhney, S.
name: Rosenstock, J.
name: McGuire, D.K.
name: Buse, J.B.
name: Danne, T.
name: Strumph, P.
name: Garg, S.K.
name: Lapuerta, P.
name: Peters, A.L.
name: Kushner, J.A.
name: Reed, J.
name: Banks, P.
name: Lane, W.S.
name: Bode, B.W.
Publisher: name: American Diabetes Association Inc.
Year: 2018

description: OBJECTIVE: Evaluate the efficacy and safety of the dual sodium-glucose cotransporter 1 (SGLT1) and SGLT2 inhibitor sotagliflozin in combination with optimized insulin in type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: The in Tandem1 trial, a double-blind, 52-week phase 3 trial, randomized North American adults with T1D to placebo (n = 268), sotagliflozin 200 mg (n = 263), or sotagliflozin 400mg(n =262) after6 weeks ofinsulin optimization. The primary end point was HbA1c change from baseline at 24 weeks. HbA1c, weight, and safety were also assessed through 52 weeks. RESULTS: From a mean baseline of 7.57%, placebo-adjusted HbA1c reductions were 0.36% and 0.41% with sotagliflozin 200 and 400 mg, respectively, at 24 weeks and 0.25% and 0.31% at 52 weeks (all P < 0.001). Among patients with a baseline HbA1c ≥7.0%, an HbA1c <7% was achieved by 15.7%, 27.2%, and 40.3% of patients receiving placebo, sotagliflozin 200 mg, and sotagliflozin 400 mg, respectively (P ≤ 0.003 vs. placebo) at 24 weeks. At 52 weeks, mean treatment differences between sotagliflozin 400 mg and placebo were 21.08 mmol/L for fasting plasma glucose, 24.32 kg for weight, and 215.63% for bolus insulin dose and 211.87% for basal insulin dose (all P < 0.001). Diabetes Treatment Satisfaction Questionnaire scores increased significantly by 2.5 points with sotagliflozin versus placebo (P < 0.001) at 24 weeks. Genital mycotic infections and diarrhea occurred more frequently with sotagliflozin. Adjudicated diabetic ketoacidosis (DKA) occurred in 9 (3.4%) and 11 (4.2%) patients receiving sotagliflozin 200 and 400 mg, respectively, and in 1 (0.4%) receiving placebo. Severe hypoglycemia occurred in 17 (6.5%) patients from each sotagliflozin group and 26 (9.7%) patients receiving placebo. CONCLUSIONS: In a 1-year T1D study, sotagliflozin combined with optimized insulin therapy was associated with sustained HbA1c reduction, weight loss, lower insulin dose, fewer episodes of severe hypoglycemia, improved patient-reported outcomes, and more DKA relative to placebo (ClinicalTrials.gov, NCT02384941).
Multiple stellar populations in Magellanic Cloud clusters. III. The first evidence of an extended main sequence turn-off in a young cluster: NGC1856
Creators: name: Milone, A. P.
name: Bedin, L. R.
name: Piotto, G.
name: Marino, A. F.
name: Cassisi, S.
name: Bellini, A.
name: Jerjen, H.
name: Pietrinferni, A.
name: Aparicio, A.
name: Rich, R. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Recent studies have shown that the extended main-sequence turn off (eMSTO) is a common feature of intermediate-age star clusters in the Magellanic Clouds (MCs). The most simple explanation is that these stellar systems harbor multiple generations of stars with an age difference of a few hundred Myrs. However, while an eMSTO has been detected in a large number of clusters with ages between ~1-2 Gyrs, several studies of young clusters in both MCs and in nearby galaxies do not find any evidence for a prolonged star-formation history, i.e. for multiple stellar generations. These results have suggested alternative interpretation of the eMSTOs observed in intermediate-age star clusters. The eMSTO could be due to stellar rotation mimicking an age spread or to interacting binaries. In these scenarios, intermediate-age MC clusters would be simple stellar populations, in close analogy with younger clusters. Here we provide the first evidence for an eMSTO in a young stellar cluster. We exploit multi-band Hubble Space Telescope photometry to study the ~300-Myr old star cluster NGC1856 in the Large Magellanic Cloud and detected a broadened MSTO that is consistent with a prolonged star-formation which had a duration of about 150 Myrs. Below the turn-off, the MS of NGC1856 is split into a red and blue component, hosting 33+/-5% and 67+/-5% of the total number of MS stars, respectively. We discuss these findings in the context of multiple-stellar-generation, stellar-rotation, and interacting-binary hypotheses.
description: 14 pages, 10 figures, accepted for publication in MNRAS
Revisiting the Early August 1972 Solar Storms
Creators: name: Cid, Consuelo
name: Saiz, Elena
name: Flores-Soriano, Manuel
Publisher: name: Zenodo
Year: 2022
Subjects: Solar storms
Space Weather
Interplanetary medium

description: Abstract. Between 6 and 4 August 1972 the McMath Region 11976 produced a series of brilliant flares and ejections. Their consequences were recorded at different places in the Heliosphere and on the ground. These observations allow us to revisit, in light of our most current understanding, the scenario of the propagation of the ejections through the Heliosphere. It is a complex scenario were two forward shocks observed at 0.8 AU overcome a previous one resulting in a unique shock at 2.2 AU. Also, a reverse shock is developed due to the interaction of the counterpart of an ejection and the fast stream from a coronal hole. Additionally, the radial alignment between Pioneer 9 and 10 provides an opportunity to study the radial evolution of the ejections, specifically of one driving the fourth forward shock which is non-perturbed. Using in-situ measurements of the magnetic field and the speed we determine the local expansion parameter supporting previous results where the expansion parameter is proposed to be independent of radial distance.
description: This work was supported by the MINICNN project ToWINActiveSun (PID2020-119407GB-I00) and UAH project PROMETE (2022/00081/001). We acknowledge the use of CDAWeb database (https://cdaweb.sci.gsfc.nasa.gov/index.html/) as source of Pioneer 10 data and to Ankit Rohatgi for free software WebPlotDigitizer (https://automeris.io/WebPlotDigitizer) which allowed us to digitize data from Pionner 9 and 10 and also from Prognoz and Heos.
Primum non nocere: Refocusing our attention on severe hypoglycemia prevention
Creators: name: Buse, J.B.
name: Kahkoska, A.R.
Publisher: name: American Diabetes Association Inc.
Year: 2018

description: Severe hypoglycemia, defined as low blood glucose requiring assistance for recovery, is arguably the most dangerous complication of type 1 diabetes as it can result in permanent cognitive impairment, seizure, coma, accidents, and death. Since the Diabetes Control and Complications Trial (DCCT) demonstrated that intensive intervention to normalize glucose prevents long-term complications but at the price of a threefold increase in the rate of severe hypoglycemia, hypoglycemia has been recognized as the major limitation to achieving tight glycemic control. Severe hypoglycemia remains prevalent among adults with type 1 diabetes, ranging from ∼1.4% per year in the DCCT/EDIC (Epidemiology of Diabetes Interventions and Complications) follow-up cohort to ∼8% in the T1D Exchange clinic registry
title: Cardiac MRI in patients with pacemakers?!
Creators: name: Binder, Wolfhard
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Cardiac
subject: Cardiovascular system
subject: Paediatric
subject: MR
subject: Diagnostic procedure
subject: Complications
subject: Artifacts

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: We report our experience with cardiovascular magnetic resonance (CMR) imaging in patients with cardiac pacemakers exemplarily in two adolescents with congenital heart disease...
India is an Incredible Place for Education: A Cursory Glance
Creators: name: Hashimy, Sayed Qudrat
Publisher: name: figshare
Year: 2023
Subjects: Political theory and political philosophy
Social and political philosophy
Political economy and social change
Educational technology and computing
Educational administration, management and leadership
Educational psychology
Pacific Peoples educational methods
Educational counselling
Aboriginal and Torres Strait Islander educational methods
Applied linguistics and educational linguistics
Ngā tikanga mātauranga o te Māori (Māori educational methods)
Te Whāriki - te mātauranga kōhungahunga Māori (Māori early childhood education)
Te mātauranga reo Māori (Māori language education)
Ngā kura kaupapa Māori (Māori primary education)
Te mātauranga kura tuatoru Māori (Māori higher education)
Tō te Māori mātauranga hangarau, mātauranga atu anō, mātauranga haere tonu, me te mātauranga hapori (Māori technical, further, continuing and community education)
Te mātauranga Māori i roto i te mātauranga (Mātauranga Māori in education)
Te mātauranga kura tuarua Māori (Māori secondary education)
Te urupare me te whai wāhi Māori ki te mātauranga (Māori responsiveness and engaged education)
Music education
Higher education
Economics of education
Environmental education and extension
Pacific Peoples higher education
Inclusive education
Engineering education
Special education and disability
Other education not elsewhere classified
Continuing and community education
Vocational education and training curriculum and pedagogy
Aboriginal and Torres Strait Islander secondary education
Technical, further and workplace education
Pacific Peoples technical, further, continuing and community education
Pacific Peoples early childhood education
Indian languages
Indian literature

description: India, from ancient times, has been a center of higher learning as it is one of the oldest civilizations in the world. India is known for its tremendous cultural power that has profoundly impacted the world for thousands of years. The richness of India's culture manifests in diverse traditions, languages, faiths, and rituals that lend wealth and depth.
Can we RISE to the challenge of youth-onset type 2 diabetes?
Creators: name: Buse, J.B.
name: D'Alessio, D.A.
name: Riddle, M.C.
Publisher: name: American Diabetes Association Inc.
Year: 2018

description: Over the past three decades, type 2 diabetes (T2D) in adolescents has become steadily more prevalent, raising the specter of increasing rates of premature micro- and macrovascular disease as affected youth move into adulthood. While T2D in adolescents is clearly linked to obesity, there is otherwise no explanation for the sudden appearance of what had previously been an adult condition in young people. Despite a steadily growing body of evidence descriptive of T2D in youth, there is a paucity of information comparing diabetic phenotypes in adults and teenagers. This issue of Diabetes Care contains three papers from the Restoring Insulin Secretion (RISE) Consortium that provide the most direct examination of this question yet, with the potential for new understanding of T2D.
Neoplasms reported with liraglutide or placebo in people with type 2 diabetes: Results from the LEADER randomized trial
Creators: name: Nauck, M.A.
name: Buse, J.B.
name: Jensen, T.J.
name: Calanna, S.
name: Rosenkilde, C.
Publisher: name: American Diabetes Association Inc.
Year: 2018

description: OBJECTIVE: This study explored neoplasm risk with liraglutide versus placebo in the LEADER (Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results) cohort. RESEARCH DESIGN AND METHODS: LEADER (NCT01179048) was an international, phase 3b, randomized, double-blind, controlled trial. Participants aged ≥50 years with type 2 diabetes and high cardiovascular risk were assigned 1:1 to receive liraglutide (≤1.8 mg daily; n = 4, 668) or placebo (n = 4, 672) in addition to standard care and monitored for 3.5-5 years (median follow-up 3.8 years). The occurrence of neoplasms was a prespecified, exploratory secondary end point. Post hocanalyses of the time to the first confirmed neoplasms were conducted using a Cox regression model. RESULTS: Neoplasm was confirmed in 10.1% of patients with liraglutide versus 9.0% with placebo (hazard ratio [HR] 1.12 [95% CI 0.99; 1.28]). The HR (95% CI) for liraglutide versus placebo was 1.06 (0.90; 1.25) for malignant neoplasms and 1.16 (0.93; 1.44) for benign neoplasms. Sensitivity analyses excluding neoplasms occurring <1 year or <2 years after randomization and analyses by sex provided similar results. In our main analyses, the 95% CI for the HR included one for all malignant neoplasms evaluated (including pancreatic and thyroid neoplasms) except for prostate neoplasms, which occurred in fewer liraglutide-treated patients. CONCLUSIONS: LEADER was not primarily designed to assess neoplasm risk. Firm conclusions cannot be made regarding numeric imbalances observed for individual neoplasm types (e.g., pancreatic cancer) that occurred infrequently. LEADER data do, however, exclude a major increase in the risk of total malignant neoplasms with liraglutide versus placebo. Additional studies are needed to assess longer-term exposure.
title: Screening for intracranial aneurysms: when and when not.
Creators: name: Filipe, João
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Aneurysms
subject: Screening
subject: Embolisation
subject: Cost-effectiveness
subject: MR-Angiography
subject: CT-Angiography
subject: Catheter arteriography
subject: Neuroradiology brain
subject: Interventional vascular

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Recommendationsforscreening and methodsofscreeningforunruptured intracranial aneurysms(UIA) arediscussedhere. 1. Target populations 1.1 Relatives of patients with cerebral aneurysms 1.1.1 One affected first­degree relative 1.1.2 Two or more...
India is an Incredible Place for Education: A Cursory Glance
Creators: name: Hashimy, Sayed Qudrat
Publisher: name: figshare
Year: 2022
Subjects: Political theory and political philosophy
Social and political philosophy
Political economy and social change
Educational technology and computing
Educational administration, management and leadership
Educational psychology
Pacific Peoples educational methods
Educational counselling
Aboriginal and Torres Strait Islander educational methods
Applied linguistics and educational linguistics
Ngā tikanga mātauranga o te Māori (Māori educational methods)
Te Whāriki - te mātauranga kōhungahunga Māori (Māori early childhood education)
Te mātauranga reo Māori (Māori language education)
Ngā kura kaupapa Māori (Māori primary education)
Te mātauranga kura tuatoru Māori (Māori higher education)
Tō te Māori mātauranga hangarau, mātauranga atu anō, mātauranga haere tonu, me te mātauranga hapori (Māori technical, further, continuing and community education)
Te mātauranga Māori i roto i te mātauranga (Mātauranga Māori in education)
Te mātauranga kura tuarua Māori (Māori secondary education)
Te urupare me te whai wāhi Māori ki te mātauranga (Māori responsiveness and engaged education)
Music education
Higher education
Economics of education
Environmental education and extension
Pacific Peoples higher education
Inclusive education
Engineering education
Special education and disability
Other education not elsewhere classified
Continuing and community education
Vocational education and training curriculum and pedagogy
Aboriginal and Torres Strait Islander secondary education
Technical, further and workplace education
Pacific Peoples technical, further, continuing and community education
Pacific Peoples early childhood education
Indian languages
Indian literature

description: India, from ancient times, has been a center of higher learning as it is one of the oldest civilizations in the world. India is known for its tremendous cultural power that has profoundly impacted the world for thousands of years. The richness of India's culture manifests in diverse traditions, languages, faiths, and rituals that lend wealth and depth.
(101363) Albert Cecil Lloyd
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Hypoglycemia, cardiovascular outcomes, and death: The LEADER experience
Creators: name: Zinman, B.
name: Christiansen, E.
name: Marso, S.P.
name: Buse, J.B.
name: Rasmussen, S.
name: Calanna, S.
Publisher: name: American Diabetes Association Inc.
Year: 2018

description: OBJECTIVE: In the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) cardiovascular (CV) outcomes trial (NCT01179048), liraglutide significantly reduced the risk of CV events (by 13%) and hypoglycemia versus placebo. This post hoc analysis examines the associations between hypoglycemia and CV outcomes and death. RESEARCH DESIGN AND METHODS: Patients with type 2 diabetes and high risk for CV disease (n = 9, 340) were randomized 1:1 to liraglutide or placebo, both in addition to standard treatment, and followed for 3.5-5 years. The primary end point was time to first major adverse cardiovascular event (MACE) (1, 302 first events recorded), and secondary end points included incidence of hypoglycemia. We used Cox regression to analyze time to first MACE, CV death, non-CV death, or all-cause death with hypoglycemia as a factor or time-dependent covariate. RESULTS: A total of 267 patients experienced severe hypoglycemia (liraglutide n = 114, placebo n = 153; rate ratio 0.69; 95% CI 0.51, 0.93). These patients had longer diabetes duration, higher incidence of heart failure and kidney disease, and used insulin more frequently at baseline than those without severe hypoglycemia. In combined analysis (liraglutide and placebo), patients with severe hypoglycemia were more likely to experience MACE, CV death, and all-cause death, with higher risk shortly after hypoglycemia. The impact of liraglutide on risk of MACE was similar in patients with and without severe hypoglycemia (P-interaction = 0.90). CONCLUSIONS: Patients experiencing severe hypoglycemia were at greater risk of CV events and death, particularly shortly after the hypoglycemic episode. While causality remains unclear, reducing hypoglycemia remains an important goal in diabetes management.
title: CT anatomy of paranasal sinuses.
Creators: name: Dib, Othmane
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Anatomy
subject: Ear / Nose / Throat
subject: CT
subject: Education
subject: eLearning
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: •To recall the normal anatomy of paranasal sinuses. •To know anatomic variations of paranasal sinuses. •To have a systematic way in looking for these variations in a CT...
Adiponectin, free fatty acids, and cardiovascular outcomes in patients with type 2 diabetes and acute coronary syndrome
Creators: name: Nicholls, S.J.
name: Malmberg, K.
name: Schwartz, G.G.
name: Mellbin, L.
name: Buse, J.B.
name: Stähli, B.E.
name: Schrieks, I.C.
name: Svensson, A.
name: Weichert, A.
name: Henry, R.R.
name: Neal, B.
name: Rydén, L.
name: Grobbee, D.E.
name: Tardif, J.-C.
name: Wedel, H.
name: Nozza, A.
name: Lincoff, A.M.
Publisher: name: American Diabetes Association Inc.
Year: 2018

description: OBJECTIVE: In observational cohorts, adiponectin is inversely associated and free fatty acids (FFAs) are directly associated with incident coronary heart disease (CHD). Adiponectin tends to be reduced and FFAs elevated in type 2 diabetes. We investigated relationships of adiponectin and FFA and major adverse cardiovascular events (MACEs) and death in patients with acute coronary syndrome (ACS) and type 2 diabetes using data from the AleCardio (Effect of Aleglitazar on Cardiovascular Outcomes After Acute Coronary Syndrome in Patients With Type 2 Diabetes Mellitus) trial, which compared the PPAR-α/γ agonist aleglitazar with placebo. RESEARCH DESIGN AND METHODS: Using Cox regression adjusted for demographic, laboratory, and treatment variables, we determined associations of baseline adiponectin and FFAs, or the change in adiponectin and FFAs from baseline, with MACEs (cardiovascular death, myocardial infarction, or stroke) and death. RESULTS: A twofold higher baseline adiponectin (n = 6, 998) was directly associated with risk of MACEs (hazard ratio [HR] 1.17 [95% CI 1.08-1.27]) and death (HR 1.53 [95% CI 1.35-1.73]). A doubling of adiponectin from baseline to month 3 (n = 6, 325) was also associated with risk of death (HR 1.20 [95%CI 1.03-1.41]). Baseline FFAs(n=7,038), but not change in FFAs from baseline (n = 6, 365), were directly associated with greater risk of MACEs and death. There were no interactions with study treatment. CONCLUSIONS: In contrasttoprior observational data for incident CHD, adiponectin is prospectively associated with MACEs and death in patients with type 2 diabetes and ACS, and an increase in adiponectin from baseline is directly related to death. These findings raise the possibility that adiponectin has different effects in patients with type 2 diabetes and ACS than in populations without prevalent cardiovascular disease. Consistent with prior data, FFAs are directly associated with adverse outcomes.
Spallation reactions. A successful interplay between modeling and applications
Creators: name: David, J. -C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The spallation reactions are a type of nuclear reaction which occur in space by interaction of the cosmic rays with interstellar bodies. The first spallation reactions induced with an accelerator took place in 1947 at the Berkeley cyclotron (University of California) with 200 MeV deuterons and 400 MeV alpha beams. They highlighted the multiple emission of neutrons and charged particles and the production of a large number of residual nuclei far different from the target nuclei. The same year R. Serber describes the reaction in two steps: a first and fast one with high-energy particle emission leading to an excited remnant nucleus, and a second one, much slower, the de-excitation of the remnant. In 2010 IAEA organized a worskhop to present the results of the most widely used spallation codes within a benchmark of spallation models. If one of the goals was to understand the deficiencies, if any, in each code, one remarkable outcome points out the overall high-quality level of some models and so the great improvements achieved since Serber. Particle transport codes can then rely on such spallation models to treat the reactions between a light particle and an atomic nucleus with energies spanning from few tens of MeV up to some GeV. An overview of the spallation reactions modeling is presented in order to point out the incomparable contribution of models based on basic physics to numerous applications where such reactions occur. Validations or benchmarks, which are necessary steps in the improvement process, are also addressed, as well as the potential future domains of development. Spallation reactions modeling is a representative case of continuous studies aiming at understanding a reaction mechanism and which end up in a powerful tool.
description: 59 pages, 54 figures, Review
(101364) Emily Hearder Lloyd
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The risk of acute pancreatitis after initiation of dipeptidyl peptidase 4 inhibitors: Testing a hypothesis of subgroup differences in older U.S. adults
Creators: name: Funk, M.J.
name: Pate, V.
name: Hong, J.-L.
name: Stürmer, T.
name: Buse, J.B.
Publisher: name: American Diabetes Association Inc.
Year: 2018

description: OBJECTIVE To examine whether dipeptidyl peptidase 4 inhibitors (DPP-4I) increase acute pancreatitis risk in older patients and whether the association varies by age, sex, and history of cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS We conducted a cohort study of DPP-4I initiators versus thiazolidinedione (TZD) or sulfonylurea initiators using U.S.Medicare beneficiaries, 2007-2014. Eligible initiators were aged 66 years or older without history of pancreatic disease or alcohol-related diseases. Patients were followed up for hospitalization due to acute pancreatitis and censored at 90 days after treatment changes. Weighted Cox models were used to estimate the hazard ratio (HR) for acute pancreatitis. Analyses were performed overall as well as within subgroups defined by age, sex, and CVD history. RESULTS We found no increased risk of acute pancreatitis comparing 49,374 DPP-4I initiators to 132,223 sulfonylurea initiators (weighted HR 1.01; 95% CI 0.83-1.24) and comparing 57,301 DPP-4I initiators to 32,612 TZD initiators (weighted HR 1.11; 95% CI 0.76-1.62). Age and sex did not modify the association. Among patients with CVD, acute pancreatitis incidence was elevated in initiators of DPP-4I and sulfonylurea (2.3 and 2.4 per 1,000 person-years, respectively) but not in TZD initiators (1.5). Among patients with CVD, higher risk of acute pancreatitis was observed with DPP- 4I compared with TZD (weighted HR 1.84; 95% CI 1.02-3.35) but not compared with sulfonylurea. CONCLUSIONS Our study provides evidence that DPP-4I is not associated with an increased risk of acute pancreatitis in older adults overall. The positive association observed in patients with CVD could be due to chance or bias but merits further investigation.
title: CT features of intra-abdominal desmoplastic small round cell tumour
Creators: name: Murazzo Vásquez, Piero
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Neoplasia
subject: Education
subject: CT
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To describe imaging findings of intra-abdominal desmoplastic small round cell tumors. To describe tumoral response after initial chemotherapy...
Increased risk of severe hypoglycemic events before and after cardiovascular outcomes in TECOSSuggests an at-risk type 2 diabetes frail patient phenotype
Creators: name: Standl, E.
name: Stevens, S.R.
name: Van De Werf, F.
name: Green, J.B.
name: Chan, J.C.N.
name: Holman, R.R.
name: Peterson, E.D.
name: Armstrong, P.W.
name: Scheen, A.
name: Travert, F.
name: Lachin, J.M.
name: Buse, J.B.
Publisher: name: American Diabetes Association Inc.
Year: 2018

description: OBJECTIVE Severe hypoglycemic events (SHEs) in type 2 diabetes are associated with subsequent cardiovascular (CV) event risk. We examined whether CV events were associated with subsequent SHE risk. RESEARCH DESIGN AND METHODS Time-dependent associations between SHEs and a composite CV end point (fatal/ nonfatal myocardial infarction or stroke, hospitalization for unstable angina, hospitalization for heart failure [hHF]) were examined post hoc in 14,671 TECOS (Trial Evaluating Cardiovascular Outcomes With Sitagliptin) participants with type 2 diabetes and CV disease followed for a median of 3.0 years. RESULTS SHEs were uncommon and unassociated with sitagliptin therapy (N = 160 [2.2%], 0.78/100 patient-years vs. N = 143 [1.9%], 0.70/100 patient-years for placebo; hazard ratio [HR] 1.12 [95%CI 0.89, 1.40], P = 0.33). Patients with (versus without) SHEs were older with longer diabetes duration, lower body weight, and lower estimated glomerular filtration rate; were more frequently women, nonwhite, and insulin treated; and more often had microalbuminuria or macroalbuminuria. Analyses adjusted for clinical factors showed SHEs were associated with increased risk of the primary composite CV end point (1.55 [1.06, 2.28], P = 0.025), all-cause death (1.83 [1.22, 2.75], P = 0.004), and CV death (1.72 [1.02, 2.87], P = 0.040). Conversely, nonfatal myocardial infarction (3.02 [1.83, 4.96], P < 0.001), nonfatal stroke (2.77 [1.36, 5.63], P = 0.005), and hHF (3.68 [2.13, 6.36], P < 0.001) were associated with increased risk of SHEs. Fully adjusted models showed no association between SHEs and subsequent CV or hHF events, but the association between CV events and subsequent SHEs remained robust. CONCLUSIONS These findings, showing greater risk of SHEs after CV events and greater risk of CV events after SHEs, suggest a common at-risk type 2 diabetes frail patient phenotype.
title: Iatrogenic injuries to celiac artery, hepatic artery and its branches during the percutaneous hepatic angiography: management, follow-up and outcomes.
Creators: name: Bangaragiri, Ajay
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Angioplasty
subject: CT-Angiography
subject: Catheter arteriography
subject: Management
subject: Interventional vascular
subject: Gastrointestinal tract
subject: Diagnostic procedure
subject: Complications
subject: Dissection
subject: Outcomes

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: 1. To diagnose the celiac, hepatic artery injuries during the hepatic angiography. 2. Intra procedural management of celiac and hepatic artery injuries. 3. Follow-up and outcome of the iatrogenic hepatic artery...
UAH VLF Antenna Python Software Development
Creators: name: Nuñez, Sergio
name: Guerrero, Antonio
name: Cid, Consuelo
Publisher: name: Zenodo
Year: 2022
Subjects: VLF antenna
Solar flares
Space weather

description: Abstract. Solar flares are powerful releases of electromagnetic energy in the solar atmosphere, which are observed at all wavelengths from radio waves to gamma-rays. For flaring monitoring, major agencies rely nowadays on measurements of solar soft X-ray emission such as from the GOES spacecraft observations, although other ground-based flare monitoring activity exist, e.g. in H-alpha observations. Nevertheless, flares can also be monitored by considering the propagation of radio waves of distant VLF transmitters which not only gives information about the flare but also about the actual impact on the Earth. The VLF monitoring station at the University of Alcala has been working since 2017 capturing the signal from different stations around the world. The recent increase in activity of the Sun has provided several flares that have allowed to obtain actual data of ionospheric disturbances and the evaluation of procedures to obtain a proper nowcasting of the disturbances towards a validation with GOES data. The objective is to have an operational product for space weather purposes. In this work we present our last results towards this objective.
description: This work was supported by the MINICNN project ToWINActiveSun (PID2020-119407GB-I00) and UAH project PROMETE (2022/00081/001). We acknowledge the use of CDAWeb database (https://cdaweb.sci.gsfc.nasa.gov/index.html/) as source of Pioneer 10 data and to Ankit Rohatgi for free software WebPlotDigitizer (https://automeris.io/WebPlotDigitizer) which allowed us to digitize data from Pionner 9 and 10 and also from Prognoz and Heos.
Morse inequalities for Fourier components of Kohn-Rossi cohomology of CR manifolds with $S^1$-action
Creators: name: Hsiao, Chin-Yu
name: Li, Xiaoshan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Complex Variables (math.CV)
subject: FOS: Mathematics

description: Let $X$ be a compact connected CR manifold of dimension $2n-1, n\geq 2$ with a transversal CR $S^1$-action on $X$. We study the Fourier components of the Kohn-Rossi cohomology with respect to the $S^1$-action. By studying the Szegö kernel of the Fourier components we establish the Morse inequalities on $X$. Using the Morse inequalities we have established on $X$ we prove that there are abundant CR functions on $X$ when $X$ is weakly pseudoconvex and strongly pseudoconvex at a point.
description: 25 pages, title changed, main results added, to be published in Math. Z
Estimates for the number of visible galaxy-spanning civilizations and the cosmological expansion of life
Creators: name: Olson, S. Jay
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Popular Physics (physics.pop-ph)
subject: FOS: Physical sciences

description: If advanced civilizations appear in the universe with an ability and desire to expand, the entire universe can become saturated with life on a short timescale, even if such expanders appear rarely. Our presence in an apparently untouched Milky Way thus constrains the appearance rate of galaxy-spanning Kardashev type III (K3) civilizations, if it is assumed that some fraction of K3 civilizations will continue their expansion at intergalactic distances. We use this constraint to estimate the appearance rate of K3 civilizations for 81 cosmological scenarios by specifying the extent to which humanity is a statistical outlier. We find that in nearly all plausible scenarios, the distance to the nearest visible K3 is cosmological. In searches for K3 galaxies where the observable range is limited, we also find that the most likely detections tend to be expanding civilizations who have entered the observable range from farther away. An observation of K3 clusters is thus more likely than isolated K3 galaxies.
description: 11 pages, 3 figures. In press, International Journal of Astrobiology. v2: Discussion added. Figures re-formated. Typos corrected. References added and updated
Strongly lensed stars at extreme magnification factors
Creators: name: Palencia, J.M.
name: J. M. Diego
name: B. J. Kavanagh
Publisher: name: Zenodo
Year: 2022
Subjects: Gravitational lensing: micro, strong - Extreme magnification factors

description: Microlensing of stars in galaxies lensed by clusters can lead to temporary extreme magnification factors (μ > 1000), boosting their apparent magnitudes above current detection thresholds. After Icarus, a series of stars have been detected at cosmological distances by the Hubble Space Telescope, and the number of such detections is expected to skyrocket with the James Webb Space Telescope. In this work we have generated state-of-the-art simulations and studied the role that different parameters play into the probability of magnification of this relatively new branch of gravitational lensing.
The demographics of dynamically-formed binary black holes in star clusters
Creators: name: Pina, Daniel Marín
Publisher: name: Zenodo
Year: 2022
Subjects: star clusters
cluster dynamics
dynamical binaries
gravitational waves

description: Dynamical binaries are formed from unbound objects by multiple-body interactions in the centre of star clusters. These binaries release energy by shrinking their orbital radius via encounters with single objects, which prevents the core collapse of globular clusters. This process is one of most important pathways for the formation of black hole mergers and the production of gravitational waves.
 If we take their formation rate, the maximum binding energy and its increase rate due to binary-single encounters, we should expect many binaries, increasing with lower cluster masses. Instead, in N-body simulations we find that there is only one dynamical binary at any given moment in a cluster. This discrepancy can be explained by binary-binary encounters, which are very effective at disrupting binaries. Such interactions may cause mergers with characteristic observables (i.e. orbital eccentricity) so neglecting them may have led us to wrongly predict the distribution of gravitational wave observables.
 Improving our understanding of these observables will open up new probes for studying star clusters.