cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Role of herpes simplex virus type-1-encoded glycoprotein C in coagulation factor X binding to the virus
Creators: name: Livingston, Joel Reed
Publisher: name: University of British Columbia
Year: 2009

description: Members of the Herpesvirus family, including herpes simplex virus type 1 (HSV-1) have been linked to vascular disease due to their ability to promote a procoagulant phenotype within the host vasculature. Previous studies have shown that HSV-1 is able to activate the blood coagulation zymogen, factor X (FX) to factor Xa (FXa). FXa, the enzymatic portion of the prothombinase complex, cleaves prothrombin into thrombin, which causes the generation of the fibrin clot and also functions as a potent cell agonist. The production of FXa is normally limited to the site of vascular damage, where procoagulant, anionic phospholipid (aPL) and tissue factor (TF) become exposed and available to plasma clotting factors. Exposure of aPL allows FX to bind to the phospholipid membrane in a Ca²⁺-dependent manner, whereas TF exposure leads to the formation of a TF-factor Vila (FVIIa) complex, known as tenase, which activates FX to FXa. Previously, our laboratory has reported that HSV-1 possesses aPL and TF, enabling them to activate FX and subsequently generate thrombin prior to affecting the host cell. It was also shown that a TF-independent pathway for FX activation involving the virus-encoded protein, glycoprotein C (gC), exists on the HSV-1 surface. Using differential sedimentation to separate bound from free 125l-ligand, we now report that in the presence of Ca²⁺, FX binds directly to purified wild type HSV-1 with an apparent dissociation constant (Kd) of 1.5 μM and has approximately 200 binding sites per virus. Demonstrating an involvement of gC, the number of FX binding sites on gC-deficient virus was reduced to 43, and residual binding had an altered KD ( 0.7 | JM ). Engineering gC back into the deficient strain or addition of a soluble recombinant form of gC (sgC), returned binding to that of wild type. Consistent with a gC:FX stoichiometry of 1:1, approximately 100 ¹²⁵l - sgC were found to bind per virus. In the absence of Ca²⁺, the number of FX binding sites on the wild type virus was similar to the gC-deficient strain in the presence of Ca²⁺ , and direct sgC-binding was insignificant. Under these conditions, sgC inhibited the FX-virus association, suggesting a Ca²⁺-independent solution-phase interaction. Providing a molecular basis for clinical correlations between recurrent infection and vascular pathology, these data demonstrate that gC constitutes one type of direct FX-HSV-1 interaction with the likely configuration FX-gC-Ca²⁺ - virus .
Comunicação para o Turismo no Espaço Rural
Creators: name: Mariani, Milton Pasquoto
name: Gehlen, Marco Antonio
name: Mariani, Milton Pasquoto
name: Gehlen, Marco Antonio
Publisher: name: Unknown
Year: 2008
Subjects: subject: Community/Rural/Urban Development
subject: Turismo Rural
subject: Comunicação
subject: Processo Comunicacional
subject: Rural tourism
subject: Communication
subject: Communication process

description: O turismo no espaço rural é uma modalidade relativamente nova e em fase de expansão no Brasil. Atraídos por uma oportunidade de mercado, muitos empreendedores rurais encontraram no turismo rural uma alternativa de obtenção de renda extra, mas depararam-se também com iniciativas públicas e privadas ainda insuficientes para promover e fomentar a modalidade. O presente artigo apresenta algumas contribuições teóricas para uma reflexão sobre o estudo de duas áreas analisadas sob uma ótica de complementaridade: a comunicação e o turismo rural. O estudo é conduzido sob o prisma de que a atividade turística recorre à dinâmica do processo comunicacional – elemento base da comunicação – com a finalidade de estabelecer um contato cada vez mais próximo entre a oferta (atrativo turístico rural) e a procura (agências de turismo e turistas), para influenciar e conduzir o potencial turista ao “consumo” do produto turístico no espaço rural. Concluiu-se que o uso intensivo das Novas Tecnologias de Informação e Comunicação (NTICS) aparece como alternativa adequada para ampliar e fortalecer estas relações necessárias para a competitividade dos produtos turísticos no espaço rural.------------------------------In Brazil, the tourism in rural areas is relatively a new modality in expansion. Attracted by the market, many rural entrepreneurs found in rural tourism an alternative to obtain extra income, but they also encountered with both insufficient public and private initiatives to promote this kind of tourism. This article presents some theoretical contributions to the study of the two areas examined in a complementary perspective: communication and rural tourism. This study is conducted under the prism of communication process dynamics used by the tourism with the aim of establishing a close contact between supply and demand to influence and lead the potential tourists to the consumption of tourism in rural areas. It was concluded that the intense use of Information and Communication of New Technologies appears as a suitable alternative to enlarge and strengthen these relations with the rural tourism competitiveness.
Additional file 5 of Chlorhexidine for facility-based umbilical cord care: EN-BIRTH multi-country validation study
Creators: name: Sojib Bin Zaman
name: Siddique, Abu Bakkar
name: Ruysen, Harriet
name: KC, Ashish
name: Peven, Kimberly
name: Shafiqul Ameen
name: Nishant Thakur
name: Rahman, Qazi Sadeq-Ur
name: Nahya Salim
name: Rejina Gurung
name: Tazeen Tahsina
name: Rahman, Ahmed Ehsanur
name: Coffey, Patricia S.
name: Rawlins, Barbara
name: Day, Louise T.
name: Lawn, Joy E.
name: Shams El Arifeen
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy
subject: Hematology
subject: Computational Biology

description: Additional file 5. STROBE statement.
Additional file 6 of Chlorhexidine for facility-based umbilical cord care: EN-BIRTH multi-country validation study
Creators: name: Sojib Bin Zaman
name: Siddique, Abu Bakkar
name: Ruysen, Harriet
name: KC, Ashish
name: Peven, Kimberly
name: Shafiqul Ameen
name: Nishant Thakur
name: Rahman, Qazi Sadeq-Ur
name: Nahya Salim
name: Rejina Gurung
name: Tazeen Tahsina
name: Rahman, Ahmed Ehsanur
name: Coffey, Patricia S.
name: Rawlins, Barbara
name: Day, Louise T.
name: Lawn, Joy E.
name: Shams El Arifeen
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy
subject: Hematology
subject: Computational Biology

description: Additional file 6. Individual-level validation in exit-survey report of umbilical cord care practices, EN-BIRTH study (n = 12,379).
Fragment tailoring strategy to design novel chemical entities as potential binders of novel corona virus main protease
Creators: name: Chinmayee Choudhury
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: The recent pandemic of severe acute respiratory syndrome–coronavirus2 (SARS-CoV-2) infection (COVID-19) has put the world on serious alert. The main protease of SARS-CoV-2 (SARS-CoV-2-MPro) cleaves the long polyprotein chains to release functional proteins required for replication of the virus and thus is a potential drug target to design new chemical entities in order to inhibit the viral replication in human cells. The current study employs state of art computational methods to design novel molecules by linking molecular fragments which specifically bind to different constituent sub-pockets of the SARS-CoV-2-MPro binding site. A huge library of 191678 fragments was screened against the binding cavity of SARS-CoV-2-MPro and high affinity fragments binding to adjacent sub-pockets were tailored to generate new molecules. These newly formed molecules were further subjected to molecular docking, ADMET filters and MM-GBSA binding energy calculations to select 17 best molecules (named as MP-In1 to MP-In17), which showed comparable binding affinities and interactions with the key binding site residues as the reference ligand. The complexes of these 17 molecules and the reference molecule with SARS-CoV-2-MPro, were subjected to molecular dynamics simulations, which assessed the stabilities of their binding with SARS-CoV-2-MPro. Fifteen molecules were found to form stable complexes with SARS-CoV-2-MPro. These novel chemical entities designed specifically according to the pharmacophoric requirements of SARS-CoV-2-MPro binding pockets showed good synthetic feasibility and returned no exact match when searched against chemical databases. Considering their interactions, binding efficiencies and novel chemotypes, they can be further evaluated as potential starting points for SARS-CoV-2 drug discovery.
The Halo Spin Transition as a Probe of Dark Energy
Creators: name: Lee, Jounghun
name: Libeskind, Noam I
Publisher: name: arXiv
Year: 2020
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present a numerical evidence supporting the claim that the mass-dependent transitions of the halo spin orientations from the intermediate to the minor principal directions of the local tidal fields can in principle be a useful discriminator of dark energy models. We first define a spin transition zone as the mass range of the halos, $Δm_{t}$, for which the intrinsic spin alignments with the minor tidal principal directions become as strong as that with the intermediate principal directions. Then, utilizing the halo samples from the DEUS simulations performed separately for the WMAP7 $Λ$CDM, phantom DE and quintessence models, we investigate if and how the three different dark energy models differ in $Δm_{t}$. It is shown that the differences in $Δm_{t}$ among the three dark energy models are significant enough to discriminate the models from one another and robust against the variations of the smoothing scale of the tidal field and redshift. Noting that a narrower spin transition zone is more powerful as a probe of dark energy, we also show that the spin transition zones become narrower at higher redshifts, in the filamentary environments and for the case that the tidal fields are smoothed on the smaller scales. Our result is consistent with the scenario that $Δm_{t}$ is mainly determined by how fast the nonlinear evolution of the tidal field proceeds, which in turn sensitively depends on the background cosmology.
description: accepted for publication in ApJ, 13 figures, 2 tables, minor revision
Additional file 7 of Chlorhexidine for facility-based umbilical cord care: EN-BIRTH multi-country validation study
Creators: name: Sojib Bin Zaman
name: Siddique, Abu Bakkar
name: Ruysen, Harriet
name: KC, Ashish
name: Peven, Kimberly
name: Shafiqul Ameen
name: Nishant Thakur
name: Rahman, Qazi Sadeq-Ur
name: Nahya Salim
name: Rejina Gurung
name: Tazeen Tahsina
name: Rahman, Ahmed Ehsanur
name: Coffey, Patricia S.
name: Rawlins, Barbara
name: Day, Louise T.
name: Lawn, Joy E.
name: Shams El Arifeen
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy
subject: Hematology
subject: Computational Biology

description: Additional file 7. Exit-survey reported health-worker communication of Chlorhexidine application, EN-BIRTH study (n = 11,639 live births).
Optical enhancement of NMR signals in CdTe
Creators: name: Leung, Isaac J. H.
Publisher: name: University of British Columbia
Year: 2009

description: Optical pumping is a powerful tool for increasing the sensitivity of NMR experiments. While it has been widely studied in GaAs, InP and other semiconductors, no previous observations have been made using direct RF inductive NMR techniques on CdTe. We have observed optically enhanced NMR signals from ¹²³Te, ¹²⁵Te, ¹¹¹Cd and ¹¹³Cd in a single crystal of CdTe under excitation with near band-gap illumination. Unlike GaAs or InP, CdTe is unique in that the NMR observable isotopes naturally exist in very low abundances. This provided an opportunity to test the validity of two models describing the mechanism of optical enhancement. From a comparison of the amplitudes of the NMR signals observed from the different nuclear species, we conclude that the optical enhancement of the nuclear spin polarization in the bulk semiconductor is not consistent with a mechanism that relies on spin diffusion, but may be consistent with a recently proposed mechanism involving the direct polarization of the bulk from optically excited excitons. Optically enhanced NMR signals are observed at temperatures as high as 100 K using a tuneable 1 W laser.
Leveraging inter-firm influence in the diffusion of energy efficiency technologies: An agent-based model
Creators: name: Shi, Yingying
name: Zeng, Yongchao
name: Engo, Jean
name: Han, Botang
name: Li, Yang
name: Muehleisen, Ralph T
Publisher: name: arXiv
Year: 2020
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Systems and Control (eess.SY)
subject: FOS: Physical sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Energy efficiency technologies (EETs) are crucial for saving energy and reducing carbon dioxide emissions. However, the diffusion of EETs in small and medium-sized enterprises is rather slow. Literature shows the interactions between innovation adopters and potential adopters have significant impacts on innovation diffusion. Enterprises lack the motivation to share information, and EETs usually lack observability, which suppress the inter-firm influence. Therefore, an information platform, together with proper policies encouraging or forcing enterprises to disclose EET-related information, should help harness inter-firm influence to accelerate EETs' diffusion. To explore whether and how such an information platform affects EETs' diffusion in small and medium-sized enterprises, this study builds an agent-based model to mimic EET diffusion processes. Based on a series of controlled numerical experiments, some counter-intuitive phenomena are discovered and explained. The results show that the information platform is a double-edged sword that notably accelerates EETs' diffusion by approximately 47% but may also boost negative information to diffuse even faster and delay massive adoption of EETs. Increasing network density and the intensity of inter-firm influence are effective to speed EET diffusion, but their impacts diminish drastically after reaching some critical values (0.05 and 0.15 respectively) and eventually harm the stability of the system. Hence, the findings implicate that EET suppliers should carefully launch their promising but immature products; policies that can reduce the perceived risk by enterprises and the effort to maintain an informative rather than judgmental information platform can prominently mitigate the negative side effects brought by high fluidity of information.
ENERGIAS RENOVÁVEIS: FUTURO DO PLANETA E INCLUSÃO SOCIAL
Creators: name: Pacheco, Carlos Thadeu
name: Pacheco, Carlos Thadeu
Publisher: name: Unknown
Year: 2008
Subjects: subject: Resource /Energy Economics and Policy
subject: biodiesel
subject: produção
subject: consumo
subject: petróleo
subject: energético
subject: production
subject: oil
subject: energy

description: Atualmente, cerca de 5% de toda a energia produzida no planeta é de fonte renovável. O grande mercado energético brasileiro e mundial poderá dar sustentação a um imenso programa de geração de emprego e renda a partir da produção do biodiesel. Mais do que opções de matérias-primas, existem diferenças importantes com relação aos conhecimentos tecnológicos utilizados para a produção e consumo de biodiesel e derivados de petróleo, que os configuram como trajetórias tecnológicas distintas e concorrentes no mercado de combustíveis.-----------------------------------Currently, about 5% of all the energy produced in the planet it is of renewable source. The great Brazilian and world-wide energy market iwill be able to give to sustentation to an immense program of generation of job and income from the production of biodiesel. More than what raw material options, exist important differences with regard to the technological knowledge used for the production and consumption of biodiesel and derivatives of oil, configure that them as distinct and competing technological trajectories in the fuel market.
Noncommutative Geometry and Cosmology
Creators: name: Barbosa, G. D.
name: Pinto-Neto, N.
Publisher: name: arXiv
Year: 2004
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We study some consequences of noncommutativity to homogeneous cosmologies by introducing a deformation of the commutation relation between the minisuperspace variables. The investigation is carried out for the Kantowski-Sachs model by means of a comparative study of the universe evolution in four different scenarios: the classical commutative, classical noncommutative, quantum commutative, and quantum noncommutative. The comparison is rendered transparent by the use of the Bohmian formalism of quantum trajectories. As a result of our analysis, we found that noncommutativity can modify significantly the universe evolution, but cannot alter its singular behavior in the classical context. Quantum effects, on the other hand, can originate non-singular periodic universes in both commutative and noncommutative cases. The quantum noncommutative model is shown to present interesting properties, as the capability to give rise to non-trivial dynamics in situations where its commutative counterpart is necessarily static.
description: 22 pages, 5 figures, substantial changes in the presentation, results are the same, to appear in Physical Review D
Additional file 8 of Chlorhexidine for facility-based umbilical cord care: EN-BIRTH multi-country validation study
Creators: name: Sojib Bin Zaman
name: Siddique, Abu Bakkar
name: Ruysen, Harriet
name: KC, Ashish
name: Peven, Kimberly
name: Shafiqul Ameen
name: Nishant Thakur
name: Rahman, Qazi Sadeq-Ur
name: Nahya Salim
name: Rejina Gurung
name: Tazeen Tahsina
name: Rahman, Ahmed Ehsanur
name: Coffey, Patricia S.
name: Rawlins, Barbara
name: Day, Louise T.
name: Lawn, Joy E.
name: Shams El Arifeen
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy
subject: Hematology
subject: Computational Biology

description: Additional file 8. Validation register-recorded umbilical cord care practices, EN-BIRTH study (n = 10,772).
What is the Deal with Local Food Systems: Or, Local Food Systems from a Regional Science Perspective
Creators: name: Hughes, David W.
name: Eades, Daniel C.
name: Robinson, Kenneth L.
name: Carpio, Carlos E.
name: Isengildina, Olga
name: Brown, Cheryl
name: Hughes, David W.
name: Eades, Daniel C.
name: Robinson, Kenneth L.
name: Carpio, Carlos E.
name: Isengildina, Olga
name: Brown, Cheryl
Publisher: name: Unknown
Year: 2007
Subjects: Community/Rural/Urban Development

description: Various types of local food systems are being touted as a means of engendering local economic growth and reducing environmental impacts of food production in general (by reducing the so-called food mile). These systems include farmers’ markets, community supported agriculture (CSAs), u-pick operations, and other forms of direct to consumers marketing. Also included are direct linkages between farmers and local restaurants or grocery stores. However, most discussions of local food systems have not received rigorous analysis based on tools of regional science. Using the Porter Diamond as a starting point, we will provide a preliminary critique of the current literature and how regional science may be used in analyzing local food systems. We also include some discussion concerning local food systems as an economic development tool. Also included is an analysis of the literature concerning the potential environmental benefits of local food systems.
description: Paper presented at the 54th Annual North American Meetings of the Regional Science Association International, Savannah GA, November 7th -10th, 2007. Preliminary version, please do not quote without permission of the contact author.
Elaboración de vinos
Creators: name: FLORES, GINNA
Publisher: name: figshare
Year: 2021
Subjects: subject: 70604 Oenology and Viticulture
subject: FOS: Agriculture, forestry and fisheries

description: Elaboración de vino casero, utilizando uvas de la variedad Moscatel, Red globe, Borgoña, utilizando los parámetros visuales, olfativo y gustativo para la evaluación final.
Intracluster Planetary Nebulae in the Virgo Cluster III: Luminosity of the Intracluster Light and Tests of the Spatial Distribution
Creators: name: Feldmeier, John
name: Ciardullo, Robin
name: Jacoby, George
name: Durrell, Patrick
Publisher: name: arXiv
Year: 2004
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Intracluster planetary nebulae are a useful tracer of the evolution of galaxies and galaxy clusters. We analyze our catalog of 318 intracluster planetary nebulae candidates found in 0.89 square degrees of the Virgo cluster. We give additional evidence for the great depth of the Virgo cluster's intracluster stellar population, which implies that the bulk of the intracluster stars come from late-type galaxies and dwarfs. We also provide evidence that the intracluster stars are clustered on the sky on arcminute scales, in agreement with tidal-stripping scenarios of intracluster star production. Although significant systematic uncertainties exist, we find that the average fraction of intracluster starlight in the Virgo is 15.8% +/- 3.0% (statistical) +/- 5.0% (systematic), and may be higher if the intracluster stars have a large spatial line-of-sight depth. We find that the intracluster star density changes little with radius or projected density over the range surveyed. These results, along with other intracluster star observations, imply that intracluster star production in Virgo is ongoing and consistent with the cluster's known dynamical youth.
description: Accepted for publication by the Astrophysical Journal. 36 pages, 5 figures v2: Fixed a typo in the abstract and text. Added additional references on request. Conclusions unchanged from previous version
Learning Vector Quantization for the Real-World: Privacy, Robustness, and Sparsity
Creators: name: Brinkrolf, Johannes
Publisher: name: Universität Bielefeld
Year: 2023
Subjects: subject: 006

description: Machine Learning (ML) methods are increasingly used and outperform humans in many specified and well-defined tasks. Considerable research focuses on optimizing the performance of such methodologies. However, the nature of application areas poses further challenges. For example, in critical domains, a false model behavior poses the risk of fatal mistakes. This is particularly relevant in traffic or medicine. In the latter, the data frequently contains sensitive information which should be preserved. Further, much data are recorded on distributed devices with limited computational power, like smartphones and peripheral devices. Hence, models of low complexity are required. As due to technical, legal, or strategic constraints, data transfer is limited employing intelligent mechanisms is crucial. This requires the consideration of further aspects beyond mere accuracy, namely privacy, robustness, efficiency, and distribution of the data itself.

In this thesis, I address these additional aspects, namely privacy, robustness, efficiency, and distribution of the data for prototype-based classifiers. In particular, I focus on Generalized Learning Vector Quantization (GLVQ) models and their variation to metric adaptations.
I show that the original GLVQ model bears the risk of revealing private information of samples present during the training. I propose three versions of training schemes provably obeying privacy. Further, I propose a novel reject option scheme for GLVQ models. Thereby increasing the robustness of the model is achieved. To reduce the complexity of a model and obtain a sparse representation of feature vectors, I apply regularization to the GLVQ scheme. Finally, I propose a methodology fusing model parameters of several models trained on distributed data sets.
A Comprehensive Review of Wind Energy in Malaysia: Past, Present and Future Research Trends
Creators: name: Noman, Fuad
name: Alkawsi, Gamal
name: Abbas, Dallatu
name: Alkahtani, Ammar
name: Tiong, Seih Kiong
name: Ekanyake, Janaka
Publisher: name: arXiv
Year: 2020
Subjects: subject: Systems and Control (eess.SY)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Wind energy has gained a huge interest in the recent years in various countries due to the high demand of energy and the shortage of traditional electricity sources. This is because it is cost effective and environmentally friendly source that could contribute significantly to the reduction of the ever-increasing carbon emissions. Wind energy is one of the fastest growing green technology worldwide with a total generation share of 564 GW as the end of 2018. In Malaysia, wind energy has been a topic of interest in both academia and green energy industry. In this paper, the current status of wind energy research in Malaysia is reviewed. Different contributing factors such as potentiality and assessments, wind speed and direction modelling, wind prediction and spatial mapping, and optimal sizing of wind farms are extensively discussed. This paper discusses the progress of all wind studies and presents conclusions and recommendations to improve wind research in Malaysia.
description: 25 pages, 3 figures
Polski system medialny w procesie zmian. T. 1
Creators: name: (:Unav)
Publisher: name: Wydawnictwo Uniwersytetu Jana Kochanowskiego w Kielcach
Year: 2021

description: The Polish media system in the process of transformation is a multi-author monograph focusing on contemporary media and related topics, including the crisis of print media and the function of internet radio. The authors of these articles assess the influence of new technologies on the media system, transformations in the press, radio and television, and analyse the role of social media in politics and shaping public opinion. The publication consists of three parts: Old and new media, Broadcasters and their messages and New style communication. Part One focuses on media itself – old media (press, radio and film) and new media (social media), which has developed due to the internet. The Polish media system also addresses issues such as media in crisis situations, journalism as a profession, the professionalism of creators, and media content (Part Two). No study of contemporary media could go without discussion of platforms like Facebook, Twitter and YouTube, as well as new professions like ‘influencer’ and ‘YouTuber’. Part Three examines the popularity of negative influencers, video games and sports channels. The collection of articles ends with a subsection on the processes of activating and operating Child Alert – a media system whose purpose is to recover missing children.
description: Polski system medialny w procesie zmian to wieloautorska monografia ujmująca zagadnienia dotyczące współczesnych mediów i zjawisk z nimi związanych, takich jak kryzys mediów papierowych czy funkcjonowanie radia w internecie. Autorzy w artykułach szukają odpowiedzi na pytania o wpływ nowych technologii na system medialny, o przeobrażenia zachodzące w prasie, radiu i telewizji, o rolę mediów społecznościowych w polityce i w kształtowaniu opinii publicznej. Publikacja składa się z trzech części: Media stare i nowe, Nadawcy i ich przekazy oraz Komunikowanie w nowym stylu. Część pierwsza skupia się na samych mediach – starych, czyli prasie, radiu, filmie, oraz nowych, rozwijających się dzięki internetowi mediach społecznościowych. Polski system medialny dotyka także kwestii roli mediów w sytuacjach kryzysowych oraz zawodu dziennikarskiego, profesjonalizmu twórców, kontentu mediów (część druga). W dysertacji na temat nowoczesnych mediów nie mogło zabraknąć rozważań o portalach: Facebooku, Twitterze i YouTubie, a także takich nowych zawodach, jak influencer i youtuber. W części trzeciej pojawiły się również zagadnienia popularności tzw. patocelebrytów, gier wideo, kanałów sportowych. Zbiór zamyka podrozdział przedstawiający proces uruchamiania i działania Child Alert – systemu medialnego mającego na celu odszukanie zaginionego dziecka.
A charged residue in the turret or outer pore mouth of hKv1.5 alters macroscopic current kinetics
Creators: name: Lee, Logan Eric Elmer
Publisher: name: University of British Columbia
Year: 2009

description: Using hKvl.5 expressed in HEK-293 cells the roles of R487 and H463 in the processes of permeation and inactivation were studied. Mutation of the arginine at position 487 to a valine (R487V) alters the I-Vrelationship through Kvl.5 such that the normalized current at positive voltages, in symmetrical 140 mM K+ , is less than at negative voltages. The magnitude of current reduction at positive voltages was unaffected by extracellular acidification suggesting that the protonation state of H463 does not effect the rate of K + exit or entry at the outer pore mouth. Using an Eyring-rate model we have ascertained that the reduction in the normalized outward currents through R487V occurs through a change at the outer pore mouth that alters the permeation process. In addition to the role of R487V in the process of permeation, it has also been shown that a histidine residue at position 463 in Kvl.5 confers sensitivity to external protons and affects the rate, of inactivation. To further investigate the role these residues, R487 and H463, on Kvl.5 macroscopic current kinetics we engineered a double mutant that swapped the residues at positions 463 and 487. In Kvl.5 H463R/R487H there was a decrease in the time constant for inactivation and an increase in the time constant for recovery from inactivation. Elevation of K + 0 (140 mM) increased the time constant for inactivation and deactivation through a 'foot-in-the-door' mechanism by which elevated K + 0 occupies an outer and inner binding site, respectively, at the selectivity filter and prevents the pore from collapsing. These results support the hypothesis that processes of activation/deactivation and inactivation are not separate entities, but rather, alterations of one parameter can have dramatic effects on the other in Kvl.5.
How Does a Fundamental String Stretch its Horizon?
Creators: name: Sen, Ashoke
Publisher: name: arXiv
Year: 2004
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: It has recently been shown that if we take into account a class of higher derivative corrections to the effective action of heterotic string theory, the entropy of the black hole solution representing elementary string states correctly reproduces the statistical entropy computed from the degeneracy of elementary string states. So far the form of the solution has been analyzed at distance scales large and small compared to the string scale. We analyze the solution that interpolates between these two limits and point out a subtlety in constructing such a solution due to the presence of higher derivative terms in the effective action. We also study the T-duality transformation rules to relate the moduli fields of the effective field theory to the physical compactification radius in the presence of higher derivative corrections and use these results to find the physical radius of compactification near the horizon of the black hole. The radius approaches a finite value even though the corresponding modulus field vanishes. Finally we discuss the non-leading contribution to the black hole entropy due to space-time quantum corrections to the effective action and the ambiguity involved in comparing this result to the statistical entropy.
description: LaTeX file, 38 pages; v2: minor changes and added references
A Low-Cost, Open-Source Automated System for the Assessment of Rat Cognitive Behavior
Creators: name: Namdarzadeh, Behnaz
name: Faraji, Parisa
name: Naji, Alireza
name: Vahabie, Abdol-hossein
name: Rezayat, Ehsan
Publisher: name: Zenodo
Year: 2023
Subjects: rat behavior
cognitive assessment
automation
open-source software
low-cost setup

description: Introduction:

The study of cognitive functions in animal models, particularly rats, plays an essential role in advancing our understanding of brain mechanisms and potential interventions. Yet, the challenge faced by many researchers and institutions is the prohibitive cost and the task-specific limitations of commercial behavioral assessment systems. Addressing these challenges, we sought to develop and validate a flexible, economical system suitable for a broad range of cognitive tasks.

Methods:

The newly developed automated system is driven by a user-friendly, open-source software platform. This setup prioritizes adaptability, allowing potential modifications to accommodate diverse cognitive tasks. We detail the design criteria, materials used, and software architecture, ensuring its replicability across various research settings. To validate its efficacy, we employed this system in a specific cognitive task tailored to evaluate rat cognitive behavior.

Results:

Preliminary findings revealed that our system reliably assessed the designated cognitive task, delivering consistent and reproducible results. The data generated was comparable to those obtained from more established, high-cost systems, showcasing the system's robustness and precision. Further, the open-source nature of the software allowed for streamlined data extraction, analysis, and interpretation, thus simplifying the research workflow.

Conclusion:

Our low-cost, open-source automated system provides a promising alternative for cognitive behavioral assessments in rats. While the initial validation focused on one specific task, the system's inherent flexibility underscores its potential applicability across a multitude of cognitive tasks. By bridging the gap between cost and functionality, this system is poised to democratize cognitive assessments, making sophisticated setups more accessible to a broader range of researchers and institutions. Future endeavors could expand the system's repertoire, adapting it to a more extensive array of cognitive tasks and potentially even other animal models.
Embodied Wisdom as Groundbreaking Practice
Creators: name: O'Donnell, Joan
Publisher: name: figshare
Year: 2020
Subjects: subject: 170112 Sensory Processes, Perception and Performance
subject: FOS: Psychology

description: Account of first person process for developing embodied awareness of how to "unstick" the self from habitual ways of being by aligning body, suspending judgement, redirecting attention and letting go. Based on Social Presencing Theatre and Phenomenology
RELATIONSHIP BETWEEN SPATIAL PRICE TRANSMISSION AND GEOGRAPHICAL DISTANCE IN BRAZIL
Creators: name: Hernandez-Villafuerte, Karla Vanessa
name: Hernandez-Villafuerte, Karla Vanessa
Publisher: name: Unknown
Year: 2011
Subjects: subject: Demand and Price Analysis
subject: cointegration
subject: price transmission
subject: geographical distance
subject: structural breaks
subject: principal component regression
subject: rice
subject: Brazil

description: The price transmission between markets is often interpreted as providing insights into the market’s infrastructure efficiency and transaction costs. Thus, finding a possible explanation for the degree of integration has become an issue of special interest. Recent researchers have pointed out the distance between markets as one of the possible factors. However, the distance is closely related with other elements, such as road quality and the proximity to an export point, which affect transport costs, opportunity costs and thus the integration. Therefore, what the most important factor is when determining the relationship among markets remains unclear. The cointegration framework, OLS and principal component regressions are applied in order to investigate the influence of geographical distance on the cointegration relationship between Brazil`s rice markets. In response to changes of the agricultural policies during the period of investigation, the presence of multiple structural breaks in the long run equation is allowed. The results point out a weak, negative and significant relation between distance and the elasticity of cointegration. Moreover, the region in which the market is located and a better access to export points are the main variables which defined the strength of the price transmission.
Analysis of Technical and Policy Changes for Belgian Dairy Farms Using an Estimated Augmented SGM Cost Function
Creators: name: De Blander, Rembert
name: Frahan, Bruno Henry De
name: De Blander, Rembert
name: Frahan, Bruno Henry De
Publisher: name: Unknown
Year: 2011
Subjects: Livestock Production/Industries

description: This paper provides some evidence on the evolution of marginal and average costs of dairy farms in Belgium between 1990 and 2007. It investigates the effect of the 2003 Mid-Term Review by adding time trends and linear splines to an augmented multi-input multi-output symmetric generalized McFadden cost function and estimating it using a panel of Belgian dairy farms. Existence of size, scale and scope economies in the dairy sub-sector is also examined. This exercise increases our understanding of dairy farm responses to reforms and helps envision the possible effects of ending the milk quota system as it is now planned for 2015.
Dynamics of granular avalanches caused by local perturbations
Creators: name: Emig, Thorsten
name: Claudin, Philippe
name: Bouchaud, Jean-Philippe
Publisher: name: arXiv
Year: 2004
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Surface flow of granular material is investigated within a continuum approach in two dimensions. The dynamics is described by a non-linear coupling between the two `states' of the granular material: a mobile layer and a static bed. Following previous studies, we use mass and momentum conservation to derive St-Venant like equations for the evolution of the thickness R of the mobile layer and the profile Z of the static bed. This approach allows the rheology in the flowing layer to be specified independently, and we consider in details the two following models: a constant plug flow and a linear velocity profile. We study and compare these models for non-stationary avalanches triggered by a localized amount of mobile grains on a static bed of constant slope. We solve analytically the non-linear dynamical equations by the method of characteristics. This enables us to investigate the temporal evolution of the avalanche size, amplitude and shape as a function of model parameters and initial conditions. In particular, we can compute their large time behavior as well as the condition for the formation of shocks.
description: 25 pages, 12 figures
QISHLOQ XO'JALIGIDA INNOVATSION TEXNOLOGIYALAR VA ULARNING IQTISODIY SAMARADORLIGI
Creators: name: Odiljonov Islomjon Ravshan o'g'li
Publisher: name: Zenodo
Year: 2024

description: Ushbu tezisda qishloq xo’jaligida innovatsion texnologiyalar ularning iqtisodiy samaradorligini oshirish bo’yicha fikr boradi.

Kalit so’zlar: Innovatsion faoliyat, Transfert, integratsiya
ProteinLens: a web-based application for the analysis of allosteric signalling on atomistic graphs of biomolecules
Creators: name: Mersmann, Sophia
name: Strömich, Léonie
name: Song, Florian
name: Vianello, Francesca
name: Barahona, Mauricio
name: Yaliraki, Sophia N.
Publisher: name: figshare
Year: 2020
Subjects: subject: 80301 Bioinformatics Software
subject: FOS: Computer and information sciences
subject: 60102 Bioinformatics
subject: 80505 Web Technologies (excl. Web Search)
subject: 30406 Proteins and Peptides
subject: FOS: Chemical sciences
subject: Structural Biology
subject: 10202 Biological Mathematics
subject: FOS: Mathematics

description: Allostery describes the effect of a distant binding event towards the orthosteric site activity of the same protein. Drug discovery efforts targeting allosteric modes of action have gained traction over the past decades, as allosteric binding sites provide selectivity and sensitivity advantages, especially in large protein families. However, allosteric site discovery has traditionally been serendipitous or connected to time- and effort-intensive high-throughput screenings. Computational methodologies that can provide a more targeted approach to investigate allosteric effects in protein structures are of great interest.
 We present ProteinLens, a user-friendly and interactive web application for the investigation of allosteric sites and pathways based on atomistic graph-theoretical methods. ProteinLens first obtains an atomistic, energy-weighted graph description of biomolecular structures and subsequently provides access to two computationally efficient methods for the analysis of allosteric signalling and communication, Markov transients and Bond-to-bond propensities. We obtain an atomistic graph from the 3D coordinates of proteins or protein/DNA complexes and capture the physicochemical detail by first detecting and then weighting the graph edges according to covalent and weak interactions (hydrogen bonds, electrostatic and hydrophobic interactions) between atoms. ProteinLens then further implements and scores bonds and residues through Markov transient and Bond-to-bond propensitiy analysis. The results of both methodologies are presented to the user with interactive plots and adjustable 3D structure viewers, which can also be downloaded. A putative allosteric site can be further scored in comparison to a random site through bootstrapping. Thus, ProteinLens allows the investigation of communication in structures of interest and the detection of allosteric sites and pathways. ProteinLens is implemented in Python/SQL and freely available to use at www.proteinlens.io.
Measuring the Influence of Information Networks on Transaction Costs Using a Non-parametric Regression Technique
Creators: name: Henningsen, Geraldine
name: Henningsen, Arne
name: Henning, Christian H.C.A.
name: Henningsen, Geraldine
name: Henningsen, Arne
name: Henning, Christian H.C.A.
Publisher: name: Unknown
Year: 2011
Subjects: Resource /Energy Economics and Policy

description: All business transactions as well as achieving innovations take up resources, subsumed under the concept of transaction costs (TAC). One of the major factors in TAC theory is information. Information networks can catalyse the interpersonal information exchange and hence, increase the access to nonpublic information. Our analysis shows that information networks have an impact on the level of TAC. Many resources that are sacrificed for TAC are inputs that also enter the technical production process. As most production data do not separate between these two usages of inputs, high transaction costs are unveiled by reduced productivity. A cross-validated local linear non-parametric regression shows that good information networks increase the productivity of farms. A bootstrapping procedure confirms that this result is statistically significant.
Additional file 1 of Birthweight measurement processes and perceived value: qualitative research in one EN-BIRTH study hospital in Tanzania
Creators: name: Gladstone, Miriam E.
name: Nahya Salim
name: Karama Ogillo
name: Shamba, Donat
name: Gore-Langton, Georgia R.
name: Day, Louise T.
name: Blencowe, Hannah
name: Lawn, Joy E.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Computational Biology

description: Additional file 1: Literature review search strategy, EN-BIRTH study.
Econometric Analysis of the Effects of Subsidies on Farm Production in Case of Endogenous Input Quantities
Creators: name: Henningsen, Arne
name: Kumbhakar, Subal C.
name: Lien, Gudbrand D.
name: Henningsen, Arne
name: Kumbhakar, Subal C.
name: Lien, Gudbrand D.
Publisher: name: Unknown
Year: 2011
Subjects: Agricultural and Food Policy
Productivity Analysis

description: The effect of subsidies on farm production has been a major topic in agricultural economics for several decades. We present a new approach for analyzing the effects of different types of coupled and decoupled subsidies on farm production with econometric methods. In contrast to most previous studies, our approach is entirely based on a theoretical microeconomic model, explicitly allows subsidies to have an impact on input use, and takes linkages between the farm and the farm household into account.
Superconducting Kondo phase in an orbitally-separated bilayer
Creators: name: Sousa-Júnior, Sebastião dos Anjos
name: de Lima, José P.
name: Costa, Natanael C.
name: Santos, Raimundo R. dos
Publisher: name: arXiv
Year: 2020
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: The nature of superconductivity in heavy-fermion materials is a subject under intense debate, and controlling this many-body state is central for its eventual understanding. Here, we examine how proximity effects may change this phenomenon, by investigating the effects of an additional metallic layer on the top of a Kondo-lattice, and allowing for pairing in the former. We analyze a bilayer Kondo Lattice Model with an on-site Hubbard interaction, $-U$, on the additional layer, using a mean-field approach. For $U=0$, we notice a drastic change in the density-of-states due to multiple-orbital singlet resonating combinations. It destroys the well-known Kondo insulator at half filling, leading to a metallic ground state, which, in turn, enhances antiferromagnetism through the polarization of the conduction electrons. For $U\neq 0$, a superconducting Kondo state sets in at zero temperature, with the occurrence of unconventional pairing amplitudes involving $f$-electrons. We establish that this remarkable feature is only possible due to the proximity effects of the additional layer. At finite temperatures we find that the critical superconducting temperature, $T_c$, decreases with the interlayer hybridization. We have also established that a zero temperature superconducting amplitude tracks $T_c$, which reminisces the BCS proportionality between the superconducting gap and $T_c$.
description: 11 pages, 10 figures