Associations of cardiac stress biomarkers with incident type 2 diabetes and changes in glucose metabolism: KORA F4/FF4 study
Creators: name: Sujana, Chaterina
name: Seissler, Jochen
name: Jordan, Jens
name: Rathmann, Wolfgang
name: Koenig, Wolfgang
name: Roden, Michael
name: Mansmann, Ulrich
name: Herder, Christian
name: Peters, Annette
name: Thorand, Barbara
name: Then, Cornelia
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: MR-proANP
subject: Copeptin
subject: CT-proET-1
subject: MR-proADM
subject: Cardiac stress biomarkers
subject: Type 2 diabetes
subject: Prediabetes
subject: Insulin resistance
subject: Incidence
subject: Cohort study
subject: ATRIAL-NATRIURETIC-PEPTIDE
subject: INSULIN-RESISTANCE
subject: PLASMA COPEPTIN
subject: HEART-FAILURE
subject: ADRENOMEDULLIN
subject: RISK
subject: SECRETION
subject: INFLAMMATION
subject: PREVALENCE
subject: MELLITUS
subject: DDC 610 / Medicine &amp; health

description: Abstract Background High N-terminal pro-brain-type natriuretic peptide levels have been associated with a lower risk of type 2 diabetes mellitus (T2D). However, less is known about other cardiac stress biomarkers in this context. Here we evaluated the association of mid-regional pro-atrial natriuretic peptide (MR-proANP), C-terminal pro-arginine vasopressin (copeptin), C-terminal pro-endothelin-1 (CT-proET-1) and mid-regional pro-adrenomedullin (MR-proADM) with incident T2D and changes in glucose metabolism. Methods We performed a prospective cohort study using data from the population-based KORA F4/FF4 study. 1773 participants (52.3% women) with MR-proANP measurements and 960 (52.7% women) with copeptin, CT-proET-1 and MR-proADM measurements were included. We examined associations of circulating plasma levels of MR-proANP, copeptin, CT-proET-1 and MR-proADM with incident T2D, the combined endpoint of incident prediabetes/T2D and with fasting and 2 h-glucose, fasting insulin, HOMA-IR, HOMA-B and HbA1c at follow-up. Logistic and linear regression models adjusted for age, sex, waist circumference, height, hypertension, total/HDL cholesterol ratio, triglycerides, smoking, physical activity and parental history of diabetes were used to compute effect estimates. Results During a median follow-up time of 6.4 years (25th and 75th percentiles: 6.0 and 6.6, respectively), 119 out of the 1773 participants and 72 out of the 960 participants developed T2D. MR-proANP was inversely associated with incident T2D (odds ratio [95% confidence interval]: 0.75 [0.58; 0.96] per 1-SD increase of log MR-proANP). Copeptin was positively associated with incident prediabetes/T2D (1.29 [1.02; 1.63] per 1-SD increase of log copeptin). Elevated levels of CT-proET-1 were associated with increased HOMA-B at follow-up, while elevated MR-proADM levels were associated with increased fasting insulin, HOMA-IR and HOMA-B at follow-up. These associations were independent of previously described diabetes risk factors. Conclusions High plasma concentrations of MR-proANP contributed to a lower risk of incident T2D, whereas high plasma concentrations of copeptin were associated with an increased risk of incident prediabetes/T2D. Furthermore, high plasma concentrations of CT-proET-1 and MR-proADM were associated with increased insulin resistance. Our study provides evidence that biomarkers implicated in cardiac stress are associated with incident T2D and changes in glucose metabolism.