cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Formulation of a dual drug-loaded nanoparticulate co-delivery hydrogel system and its validation in rheumatoid arthritis animal model
Creators: name: Haloi, Prakash
name: Lokesh, B. Siva
name: Chawla, Saurabh
name: Konkimalla, V. Badireenath
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified

description: Rheumatoid arthritis (RA), a systemic autoimmune disease that dramatically affects patients’ quality of life. Given the intricacy of RA’s pathophysiology, no single treatment can completely halt the disease progression. Here, we attempted to treat RA holistically and synergistically by co-delivering methotrexate (MTX), a standard slow-acting anti-rheumatic drug, and phenethyl isothiocyanate (PEITC), a bioactive phytochemical, using a sodium alginate (SA)-pluronic F127 (PF-127) in situ hydrogel formulation. Therefore, in the current study, the co-delivery of MTX and PEITC in the nanoparticulate form could help enhance stability and solubility and facilitate greater penetration in the target arthritic tissues. The fabricated MTX NP and PEITC NE were found to have a minimum particle size, PDI, and good zeta potential. Results from in vitro release studies showed that MTX and PEITC were simultaneously released from the DD NP HG matrix over 6–7 days through diffusion and erosion mechanisms. An intra-articular (IA) injection of DD NP HG dramatically reduced chronic inflammation in adjuvant-induced arthritis (AIA) rats, delayed the onset of bone erosion, significantly reduced synovitis, and down-regulated the inflammatory cytokine expression. Most notably, the co-delivery strategy almost entirely restored the morphological features of the ankle joints of RA rats. The hepatic and renal function tests indicated good biological safety for DD NP HG in RA conditions. Taken together, these findings indicated that DD NP HG could achieve good anti-inflammatory activity and reverse cartilage disruption through a synergistic effect between two nanoparticulate forms of MTX and PEITC, which can effectively improve the drawbacks of their free forms. A nanostructured dual-drug loaded smart hydrogel (DD NP HG) was successfully constructed for the intra-articular delivery of MTX and PEITC to the affected joints of RA. The fabrication of the nanoformulation of both MTX (MTX NP) and PEITC (PEITC NE) aided in mitigating the drawbacks and drug-related side effects of the free form of drugs. DD NP HG markedly suppressed joint inflammation and protect against bone destruction in arthritic rats. This combination approach of PEITC and MTX (DD NP HG) synergistically improved anti-arthritic activity and reduced the adverse side effects in vivo.
Additional file 2: of Negative correlation between rates of molecular evolution and flowering cycles in temperate woody bamboos revealed by plastid phylogenomics
Creators: name: Ma, Peng-Fei
name: Vorontsova, Maria
name: Olinirina Nanjarisoa
name: Razanatsoa, Jacqueline
name: Guo, Zhen-Hua
name: Haevermans, Thomas
name: Li, De-Zhu
Publisher: name: figshare
Year: 2017
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology
subject: Computational Biology

description: Phylogenetic relationships among major lineages of Arundinarieae based on complete plastid genomes in unpartitioned maximum likelihood (ML) (A) and Bayesian analysis (B). Values associated with the nodes indicate the ML or Bayesian support values and the unlabeled nodes receive 100% ML bootstrap support or 1.0 Bayesian posterior probability. (PDF 389Â kb)
Evolution of Nagaoka phase with kinetic energy frustrating hoppings
Creators: name: Lisandrini, F. T.
name: Bravo, B.
name: Trumper, A. E.
name: Manuel, L. O.
name: Gazza, C. J.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We investigate, using the density matrix renormalization group, the evolution of the Nagaoka state with $t'$ hoppings that frustrate the hole kinetic energy in the $U=\infty$ Hubbard model on the anisotropic triangular lattice and the square lattice with second-nearest neighbor hoppings. We find that the Nagaoka ferromagnet survives up to a rather small $t'_c/t \sim 0.2.$ At this critical value, there is a transition to an antiferromagnetic phase, that depends on the lattice: a ${\bf Q}=(Q,0)$ spiral order, that continuously evolves with $t'$, for the triangular lattice, and the usual ${\bf Q}=(π,π)$ Néel order for the square lattice. Remarkably, the local magnetization takes its classical value for all considered $t'$ ($t'/t \le 1$). Our results show that the recently found classical kinetic antiferromagnetism, a perfect counterpart of Nagaoka ferromagnetism, is a generic phenomenon in these kinetically frustrated electronic systems.
description: 7 pages, 7 figures
title: China’s future as a low carbon economy: The Chinese hard coal industry & renewable energies in perspective
Creators: name:  Tiganj ,  Julia
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: With the recently announced climate neutrality for the year 2060, there are plenty of questions in China about the future and the existence of the hard coal mining industry. With an annual production of 4 billion tons of hard coal, China remains the biggest producer of this resource. The consequences for the environment are tremendous. Climate neutrality poses new challenges for this country with its abundance of resources: hard coal is still the easiest and safest way to guarantee the supply of energy to its citizens, whereby energy security is a high priority. The switch to and the integration of renewable energies has already started and, according to the latest 14th five-year plan, should become the main driver of growth in the coming years. The transition to green development with a low carbon economy as one of the most important objectives is imminent. These developments will have a decisive impact on the next few years and will drive structural change forward. Since China also has large reserves of rare earths, which are required in particular for the construction of regenerative energy options. But here, too, only one environmental problem is shifted to the next, since the recycling of rare earths has not yet been developed and the sustainability factor is a big question mark. What impact this will have in terms of sustainability and environmental protection is identified in the research project.
title: ADCO, Cartulaire de Cîteaux pour la grange et seigneurie d'Ouges (XVe siècle), Cart. 173 (11 H 939), 226 folios, f. 0198
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2015
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Cartulaire de Cîteaux pour la grange et seigneurie d'Ouges (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 173 (11 H 939), 226 folios, f. 0198, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour la grange et seigneurie d'Ouges (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 173 (11 H 939), 226 folios, f. 0198, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Fußbälle, nicht Taschentücher. Korpuslinguistische Analysen zum Gebrauch von caused-motion-Konstruktionen in der Fußballberichterstattung
Creators: name: Meier-Vieracker, Simon
Publisher: name: Zenodo
Year: 2022
Subjects: Construction Grammar, Caused Motion, Football, Motion

description: Spätestens seit Bergs (2008) ist die caused-motion-Konstruktion, kanonisch repräsentiert in den vom Tisch geniesten Taschentüchern, zum Emblem der klassischen, argumentstrukturorientierten Konstruktionsgrammatik geworden (Goldberg 1995), auf das man kaum mehr ironiefrei Bezug nehmen kann. Für die von Bergs kritisierte Perspektive auf diese Konstruktion, der kontextfreien Durchvariation frei erdachter Beispielsätze, mag das angemessen sein. Allerdings kommt ihr tatsächlicher Gebrauch, der durch das Attribut usage-based eigentlich relevant gesetzt wird, hierbei durchgängig zu kurz, und gerade dieser eröffnet doch wieder interessante Perspektiven. Das möchte ich anhand von caused-motion-Konstruktionen in der kommunikativen Domäne der Fußballberichterstattung aufzeigen. Basierend auf den Korpora zur Fußballlinguistik (Meier 2017) werde ich in quantitativen Zugriffen Frequenzen und Varianzen von caused-Motion-Konstruktionen im Deutschen, Englischen und Niederländischen wie etwa Müller stochert den Ball über die Linie erheben, bei denen ganz im Einklang mit konstruktionsgrammatischen Deutungen die Verben durch die Konstruktion abweichende Lesarten erhalten. Die Befunde werde ich anschließend auf weiterreichende korpuslinguistische Ergebnisse zur sprachlichen Routinehaftigkeit und Schematizität der Fußballberichterstattung beziehen (Meier 2019). Über die empirische Sättigung eines konstruktionsgrammatischen Klassikers hinaus geben die Befunde somit auch erneut Anlass zur Frage, ob und wie im Konstruktionsbegriff auch eine Typik der Gebrauchssituationen und -domänen zu verankern ist (Bücker et al. 2015).
Characterising radio telescope software with the Workload Characterisation Framework
Creators: name: Grange, Y. G.
name: Lakhoo, R.
name: Petschow, M.
name: Wu, C.
name: Veenboer, B.
name: Emsley, I.
name: Dijkema, T. J.
name: Mechev, A. P.
name: Mariani, G.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Performance (cs.PF)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences
subject: D.4.8; K.6.2

description: We present a modular framework, the Workload Characterisation Framework (WCF), that is developed to reproducibly obtain, store and compare key characteristics of radio astronomy processing software. As a demonstration, we discuss the experiences using the framework to characterise a LOFAR calibration and imaging pipeline.
description: 4 pages, 4 figures; to be published in ADASS XXVI (held October 16-20, 2016) proceedings. See http://www.adass2016.inaf.it/images/posters/grange.pdf for the poster
Study of the $β$-decay of $^{100}$Tc with Total Absorption $γ$-Ray Spectroscopy
Creators: name: Guadilla, V.
name: Algora, A.
name: Tain, J. L.
name: Agramunt, J.
name: Jordan, D.
name: Montaner-Pizá, A.
name: Orrigo, S. E. A.
name: Rubio, B.
name: Valencia, E.
name: Suhonen, J.
name: Civitarese, O.
name: Äystö, J.
name: Briz, J. A.
name: Cucoanes, A.
name: Eronen, T.
name: Estienne, M.
name: Fallot, M.
name: Fraile, L. M.
name: Ganioglu, E.
name: Gelletly, W.
name: Gorelov, D.
name: Hakala, J.
name: Jokinen, A.
name: Kankainen, A.
name: Kolhinen, V.
name: Koponen, J.
name: Lebois, M.
name: Martinez, T.
name: Monserrate, M.
name: Moore, I.
name: Nácher, E.
name: Penttilä, H.
name: Pohjalainen, I.
name: Porta, A.
name: Reinikainen, J.
name: Reponen, M.
name: Rinta-Antila, S.
name: Rytkönen, K.
name: Shiba, T.
name: Sonnenschein, V.
name: Sonzogni, A. A.
name: Vedia, V.
name: Voss, A.
name: Wilson, J. N.
name: Zakari-Issoufou, A. -A.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The \b{eta}-decay of 100 Tc has been studied using the Total Absorption γ-Ray Spectroscopy technique at IGISOL. In this work the new DTAS spectrometer in coincidence with a cylindrical plastic \b{eta} detector has been employed. The \b{eta}-intensity to the ground state obtained from the analysis is in good agreement with previous high-resolution measurements. However, differences in the feeding to the first excited state as well as weak feeding to a new level at high excitation energy have been deduced from this experiment. Theoretical calculations performed in the quasiparticle random- phase approximation (QRPA) framework are also reported. Comparison of these calculations with our measurement serves as a benchmark for calculations of the double \b{eta}-decay of 100 Mo.
description: submitted to Physical Review C
New Policies and Practices for European Sharing Cities
Creators: name: Alvisi, Chiara
name: Donati, Daniele
name: Pavani, Giorgia
name: Profeti, Stefania
name: Tubertini, Claudia
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2019
Subjects: IUS/21 Diritto pubblico comparato

description: Il volume raccoglie i risultati del progetto “New Policies and Practices for European Sharing Cities –EUcity”, attivato nell’ambito dello Jean Monnet Project e co-finanziato dall’Erasmus+ Project dell’Unione Europea. Muovendo dall’assunto per il quale le città sono i principali recettori dei cambiamenti del mercato poiché si distinguono come legami interconnessi tra la società, lo Stato e l’Unione europea, gli Autori hanno analizzato il fenomeno della sharing economy, alcuni modelli di governance e di fornitura di beni e servizi sul mercato. Come illustrato dal nucleo argomentativo dell’opera, infatti, le sfide normative della sharing economy non derivano solo dalla novità del modello economico p2p, ma anche da una distribuzione completamente nuova delle responsabilità normative tra gli attori coinvolti. A differenza della regolamentazione del mercato tradizionale, la regolamentazione dell’economia della condivisione è principalmente una questione comunale. Allo stesso tempo, anche il diritto europeo offre spunti di riflessione notevoli. Attualmente, sia gli amministratori locali che gli operatori privati di alcuni settori del mercato (ad es. la casa, i trasporti, etc.), ma anche i cittadini che vogliono sperimentare nuovi servizi, sono obbligati ad agire all’interno di sistema normativo difficilmente intellegibile. In virtù delle considerazioni svolte, quindi, il testo apre un fronte critico argomentativo diviso in tre parti: 1) “Sharing cities”, in cui si introducono i temi principali relativi ai fenomeni urbani in un contesto di sharing economy; 2) “Trasporti, Turismo e politiche abitative nelle Sharing cities”, contenente un focus riguardante gli aspetti dinamici del vivere in contesti smart; 3) “Esperienze a confronto”, parte dedicata all’analisi empirica delle realtà sperimentate da Bologna e Barcellona.
Additional file 1: of Negative correlation between rates of molecular evolution and flowering cycles in temperate woody bamboos revealed by plastid phylogenomics
Creators: name: Ma, Peng-Fei
name: Vorontsova, Maria
name: Olinirina Nanjarisoa
name: Razanatsoa, Jacqueline
name: Guo, Zhen-Hua
name: Haevermans, Thomas
name: Li, De-Zhu
Publisher: name: figshare
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy

description: List of 46 bamboo taxa sampled in this study with related voucher and GenBank accession information. (DOC 97Â kb)
Fußbälle, nicht Taschentücher. Korpuslinguistische Analysen zum Gebrauch von caused-motion-Konstruktionen in der Fußballberichterstattung
Creators: name: Meier-Vieracker, Simon
Publisher: name: Zenodo
Year: 2022
Subjects: Construction Grammar, Caused Motion, Football, Motion

description: Spätestens seit Bergs (2008) ist die caused-motion-Konstruktion, kanonisch repräsentiert in den vom Tisch geniesten Taschentüchern, zum Emblem der klassischen, argumentstrukturorientierten Konstruktionsgrammatik geworden (Goldberg 1995), auf das man kaum mehr ironiefrei Bezug nehmen kann. Für die von Bergs kritisierte Perspektive auf diese Konstruktion, der kontextfreien Durchvariation frei erdachter Beispielsätze, mag das angemessen sein. Allerdings kommt ihr tatsächlicher Gebrauch, der durch das Attribut usage-based eigentlich relevant gesetzt wird, hierbei durchgängig zu kurz, und gerade dieser eröffnet doch wieder interessante Perspektiven. Das möchte ich anhand von caused-motion-Konstruktionen in der kommunikativen Domäne der Fußballberichterstattung aufzeigen. Basierend auf den Korpora zur Fußballlinguistik (Meier 2017) werde ich in quantitativen Zugriffen Frequenzen und Varianzen von caused-Motion-Konstruktionen im Deutschen, Englischen und Niederländischen wie etwa Müller stochert den Ball über die Linie erheben, bei denen ganz im Einklang mit konstruktionsgrammatischen Deutungen die Verben durch die Konstruktion abweichende Lesarten erhalten. Die Befunde werde ich anschließend mit der sprachlichen Routinehaftigkeit und Schematizität der Fußballberichterstattung in Bezug setzen (Meier 2019). Über die empirische Sättigung eines konstruktionsgrammatischen Klassikers hinaus geben die Befunde somit auch erneut Anlass zur Frage, ob und wie im Konstruktionsbegriff auch eine Typik der Gebrauchssituationen und -domänen zu verankern ist (Bücker et al. 2015).
A Qualitative Exploration of the Socioecological Influences Shaping the Diagnostic Experience and Self-Management Practices Among People Newly Diagnosed With Multiple Sclerosis
Creators: name: Wills, Olivia
name: Manche, S
name: Probst, Yasmine
Publisher: name: University of Wollongong
Year: 2025
Subjects: classificationCode: 4203
subject: Health services and systems
classificationCode: 4206
subject: Public health
classificationCode: 52
subject: Psychology
subject: FOS: Psychology
classificationCode: 4205
subject: Nursing
subject: FOS: Health sciences
classificationCode: 42
subject: Health sciences

description: Background: People newly diagnosed with multiple sclerosis (MS) often pursue ‘health-related’ behaviour changes to feel in control of their diagnosis. However, little is known about the specific factors that may influence behaviour change during this crucial time. Therefore, we conducted an in-depth exploration of the socioecological influences impacting the diagnostic experience and self-management practices following an MS diagnosis. Methods: We followed a qualitative study design using a phenomenological approach to explore the lived experiences of people newly diagnosed with MS. Analysis was conducted via an iterative process, starting with deductive open coding to map onto the socioecological model, followed by inductive focused coding to extract key themes from participants' reported experiences. Results: Eight participants diagnosed with MS within the past 12 months were interviewed. Four themes were reported across the MS journey, reflecting the different levels of the socioecological model: (1) taking control of a new diagnosis to retain a sense of personal identity—individual level; (2) grief and acceptance guided by community—social connection, community and social environment; (3) practical management of MS in the wider society—policy and government regulation; and (4) global events that greatly upheave the MS journey—natural disasters and societal conflicts, such as a pandemic. These themes highlighted the complex interrelationship between socioecological factors and self-management abilities in people living with MS. Conclusions: The diagnostic experience of those with MS is highly complex. Although it varies for each person living with MS, there are shared experiences that often reflect a common cycle of grief. An MS diagnosis provides an opportunity for self-rediscovery, which can both influence and be influenced by socioecological factors. The social and technical nature of self-managing MS strongly shapes the diagnostic experience, underpinning many aspects of daily living, social interaction and physical and psychological well-being. Patient or Public Contribution: The research team worked closely with an MS-specific consumer panel for the study design. This project was raised with this group, and preliminary results were shared at a national conference for MS during a lived-experience consumer stream to gain additional insights.
Extravasation of biodegradable microspheres in the rat brain
Creators: name: van der Wijk, Anne-Eva
name: Georgakopoulou, Theodosia
name: Steendam, Rob
name: Zuidema, Johan
name: Hordijk, Peter L.
name: Bakker, Erik N.T.P.
name: van Bavel, Ed
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified

description: Drug development for neurological diseases is greatly impeded by the presence of the blood-brain barrier (BBB). We and others previously reported on extravasation of micrometer-sized particles from the cerebral microcirculation – across the BBB – into the brain tissue over the course of several weeks. This mechanism could potentially be used for sustained parenchymal drug delivery after extravasation of biodegradable microspheres. As a first step toward this goal, we set out to evaluate the extravasation potential in the rat brain of three classes of biodegradable microspheres with drug-carrying potential, having a median diameter of 13 µm (80% within 8–18 µm) and polyethylene glycol concentrations of 0%, 24% and 36%. Extravasation, capillary recanalization and tissue damage were determined in a rat cerebral microembolization model at day 14 after microsphere injection. Microspheres of all three classes had the potential to extravasate from the vessel into the brain parenchyma, with microspheres without polyethylene glycol extravasating the fastest. Microembolization with biodegradable microspheres led to impaired local capillary perfusion, which was substantially restored after bead extravasation. We did not observe overt tissue damage after microembolization with any microsphere: we found very limited BBB disruption (IgG extravasation), no microgliosis (Iba1 staining) and no large neuronal infarctions (NeuN staining). In conclusion, biodegradable microspheres with different polymer compositions can extravasate into the brain parenchyma while causing minimal tissue damage.
title: The effectiveness of sensory integration therapy and sensory based interventions for children with an autism diagnosis in enabling functional engagement in everyday occupations: A scoping review.
Creators: name: Hitch, Danielle
name: Hennessy, Victoria
Publisher: name: OSF Registries
Year: 2024
Subjects: subject: Occupational Therapy
subject: Medicine and Health Sciences
subject: Medical Specialties
subject: Rehabilitation and Therapy
subject: Pediatrics

description: Scoping review protocol
Additional file 12: of Negative correlation between rates of molecular evolution and flowering cycles in temperate woody bamboos revealed by plastid phylogenomics
Creators: name: Ma, Peng-Fei
name: Vorontsova, Maria
name: Olinirina Nanjarisoa
name: Razanatsoa, Jacqueline
name: Guo, Zhen-Hua
name: Haevermans, Thomas
name: Li, De-Zhu
Publisher: name: figshare
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Inorganic Chemistry
subject: Computational Biology

description: Sequence length and model selected for each data partition of the coding data set. (DOC 31Â kb)
An injectable hydrogel to disrupt neutrophil extracellular traps for treating rheumatoid arthritis
Creators: name: Wang, Nan
name: Ma, Jie
name: Song, Wenxia
name: Zhao, Chengwu
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology

description: Rheumatoid arthritis (RA), an autoimmune disease, is characterized by inflammatory cell infiltration that damages cartilage, disrupts bone, and impairs joint function. The therapeutic efficacy of RA treatments with the severely affected side remains unsatisfactory despite current treatment methods that primarily focus on anti-inflammatory activity, largely because of the complicatedly pathological mechanisms. A recently identified mechanism for RA development involves the interaction of RA autoantibodies with various proinflammatory cytokines to facilitate the formation of neutrophil extracellular traps (NETs), which increased inflammatory responses to express inflammatory cytokines and chemokines. Therefore, NETs architecture digestion may inhibit the positive-feedback inflammatory signal pathway and lessen joint damage in RA. In this work, deoxyribonuclease I (DNase) is connected to oxidized hyaluronic acid (OHA) via Schiff base reaction to extend the half-life of DNase. The modification does not influence the DNase activity for plasmid deoxyribonucleic acid hydrolysis and NETs’ architecture disruption. Carboxymethyl chitosan is crosslinked with DNase-functionalised OHA (DHA) to form an injectable, degradable, and biocompatible hydrogel (DHY) to further strengthen the adhesive capability of DHA. Importantly, the collagen-induced arthritis model demonstrates that intra-articular injection of DHY can significantly reduce inflammatory cytokine expression and alleviate RA symptoms, which can be significantly improved by combining methotrexate. Here, a DNase-functionalised hydrogel has been developed for RA treatment by constantly degrading the novel drug target of NETs to decrease inflammatory response in RA.
Additional file 1: of The DESiGN trial (DEtection of Small for Gestational age Neonate), evaluating the effect of the Growth Assessment Protocol (GAP): study protocol for a randomised controlled trial
Creators: name: Vieira, Matias
name: Relph, Sophie
name: Copas, Andrew
name: Healey, Andrew
name: Coxon, Kirstie
name: Alagna, Alessandro
name: Briley, Annette
name: Johnson, Mark
name: Lawlor, Deborah
name: Lees, Christoph
name: Marlow, Neil
name: McCowan, Lesley
name: Page, Louise
name: Peebles, Donald
name: Shennan, Andrew
name: Thilaganathan, Baskaran
name: Khalil, Asma
name: Sandall, Jane
name: Pasupathy, Dharmintra
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy

description: Table S1. Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) Checklist (2013): recommended items to address in a clinical trial protocol and related documents. Table S2. Distribution of small-for-gestational-age (SGA) and expected detection rates. (DOCX 41 kb)
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome I, Cart. 185 (11 H 70), f. 0117v
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome I, Archives départementales de la Côte-d'Or, Cart. 185 (11 H 70), f. 0117v, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome I, Archives départementales de la Côte-d'Or, Cart. 185 (11 H 70), f. 0117v, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Effect of surface morphology and magnetic impurities on the electronic structure in cobalt-doped BaFe2As2 superconductors
Creators: name: Zou, Qiang
name: Wu, Zhiming
name: Fu, Mingming
name: Zhang, Chunmiao
name: Rajput, Shivani
name: Wu, Yaping
name: Li, Li
name: Parker, David S.
name: Kang, Junyong
name: Sefat, Athena S.
name: Gai, Zheng
Publisher: name: arXiv
Year: 2017
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Combined scanning tunneling microscopy, spectroscopy and local barrier height (LBH) studies show that low-temperature-cleaved optimally-doped Ba(Fe1-xCox)2As2 crystals with x=0.06, with Tc = 22 K, have complicated morphologies. Although the cleavage surface and hence the morphologies are variable, the superconducting gap maps show the same gap widths and nanometer size inhomogeneities irrelevant to the morphology. Based on the spectroscopy and LBH maps, the bright patches and dark stripes in the morphologies are identified as Ba and As dominated surface terminations, respectively. Magnetic impurities, possibly due to cobalt or Fe atoms, are believed to create local in-gap state and in addition suppress the superconducting coherence peaks. This study will clarify the confusion on the cleavage surface terminations of the Fe-based superconductors, and its relation with the electronic structures.
description: Accepted to Nano Letters (5 figures)
Additional file 1 of ELK4 promotes the development of gastric cancer by inducing M2 polarization of macrophages through regulation of the KDM5A-PJA2-KSR1 axis
Creators: name: Zheng, Lei
name: Xu, Hongmei
name: Di, Ya
name: Chen, Lanlan
name: Liu, Jiao
name: Kang, Liying
name: Gao, Liming
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Table S1. Primer sequences for RT-qPCR.
Novel tetrahydrocurcumin integrated mucoadhesive nanocomposite κ-carrageenan/xanthan gum sponges: a strategy for effective local treatment of oral cancerous and precancerous lesions
Creators: name: Elbanna, Shimaa A.
name: Ebada, Heba M. K.
name: Abdallah, Ossama Y.
name: Essawy, Marwa M.
name: Abdelhamid, Hend M.
name: Barakat, Hebatallah S.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Oral cancer is one of the leading causes of death worldwide. Oral precancerous lesions (OPL) are the precursors of oral cancer, with varying degrees of progression. Tetrahydrocurcumin (THC) is a major metabolite of curcumin with superior anticancer properties against various types of cancer. However, THC’s clinical outcome is limited by its poor aqueous solubility. Herein, we developed novel mucoadhesive biopolymer-based composite sponges for buccal delivery of THC, exploiting nanotechnology and mucoadhesion for efficient prevention and treatment of oral cancer. Firstly, THC-nanocrystals (THC-NC) were formulated and characterized for subsequent loading into mucoadhesive composite sponges. The anticancer activity of THC-NC was assessed on a human tongue squamous carcinoma cell line (SCC-4). Finally, the chemopreventive activity of THC-NC loaded sponges (THC-NC-S) was examined in DMBA-induced hamster OPL. The selected THC-NC exhibited a particle size of 532.68 ± 13.20 nm and a zeta potential of −46.08 ± 1.12 mV. Moreover, THC-NC enhanced the anticancer effect against SCC-4 with an IC50 value of 80 µg/mL. THC-NC-S exhibited good mucoadhesion properties (0.24 ± 0.02 N) with sustained drug release, where 90% of THC was released over 4 days. Furthermore, THC-NC-S had a magnificent potential for maintaining high chemopreventive activity, as demonstrated by significant regression in the dysplasia degree and a decline in cyclin D1 (control: 40.4 ± 12.5, THC-NC-S: 12.07 ± 5.2), culminating in significant amelioration after 25 days of treatment. Conclusively, novel THC-NC-S represent a promising platform for local therapy of OPL, preventing their malignant transformation into cancer.
Understanding the evolution of multimedia content in the Internet through BitTorrent glasses
Creators: name: Farahbakhsh, Reza
name: Cuevas, Angel
name: Cuevas, Ruben
name: Gonzalez, Roberto
name: Crespi, Noel
Publisher: name: arXiv
Year: 2017
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: Multimedia (cs.MM)
subject: FOS: Computer and information sciences

description: Today's Internet traffic is mostly dominated by multimedia content and the prediction is that this trend will intensify in the future. Therefore, main Internet players, such as ISPs, content delivery platforms (e.g. Youtube, Bitorrent, Netflix, etc) or CDN operators, need to understand the evolution of multimedia content availability and popularity in order to adapt their infrastructures and resources to satisfy clients requirements while they minimize their costs. This paper presents a thorough analysis on the evolution of multimedia content available in BitTorrent. Specifically, we analyze the evolution of four relevant metrics across different content categories: content availability, content popularity, content size and user's feedback. To this end we leverage a large-scale dataset formed by 4 snapshots collected from the most popular BitTorrent portal, namely The Pirate Bay, between Nov. 2009 and Feb. 2012. Overall our dataset is formed by more than 160k content that attracted more than 185M of download sessions.
description: Farahbakhsh, Reza, et al. "Understanding the evolution of multimedia content in the internet through bittorrent glasses." IEEE Network 27.6 (2013): 80-88
Additional file 11: of Negative correlation between rates of molecular evolution and flowering cycles in temperate woody bamboos revealed by plastid phylogenomics
Creators: name: Ma, Peng-Fei
name: Vorontsova, Maria
name: Olinirina Nanjarisoa
name: Razanatsoa, Jacqueline
name: Guo, Zhen-Hua
name: Haevermans, Thomas
name: Li, De-Zhu
Publisher: name: figshare
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Inorganic Chemistry
subject: Computational Biology

description: Sequence length and model selected for the three data sets used in the study. (DOC 29Â kb)
Gas Accretion via Lyman Limit Systems
Creators: name: Lehner, Nicolas
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: In cosmological simulations, a large fraction of the partial Lyman limit systems (pLLSs; 162) redshifts. Here I discuss unambiguous evidence for metal-poor gas at all z probed by the pLLSs and LLSs. At z<1, all the pLLSs and LLSs so far studied are located in the CGM of galaxies with projected distances <100-200 kpc. Regardless of the exact origin of the low-metallicity pLLSs/LLSs, there is a significant mass of cool, dense, low-metallicity gas in the CGM that may be available as fuel for continuing star formation in galaxies over cosmic time. As such, the metal-poor pLLSs and LLSs are currently among the best observational evidence of cold, metal-poor gas accretion onto galaxies.
description: Invited review to appear in Gas Accretion onto Galaxies, Astrophysics and Space Science Library, eds. A. J. Fox & R. Dav\'e, to be published by Springer
title: Spatio-temporal estimation in wireless networks with message passing
title: Χωρο-χρονική εκτίμηση σε ασύρματα δίκτυα με ανταλλαγή μηνυμάτων
Creators: name: Σαμωνακη Μαρια
Publisher: name: Technical University of Crete
Year: 2022

description: In wireless networks, position information is a vital requirement for the network to function as intended. Localization is usually based on time of arrival (TOA) measurements, and thus, accurate timing information is essential for time-based localization. In this thesis, we utilize timing and ranging information exchange between neighboring nodes to overcome this problem. Initially, we approach the problem of spatio-temporal estimation in a sequential manner. We first aim to synchronize the nodes, using prior art time synchronization methods based on linear programming or Gaussian belief propagation and then estimate their locations, using (cooperative) Gaussian belief propagation. Afterwards, we attempt to solve the problem in a joint way, by estimating the clock offsets and the locations simultaneously, assuming that the nodes exchange messages with the anchors (non-cooperatively). In both methods, we focus on proposing efficient belief propagation (BP)-based algorithms that reduce communication overhead and computational complexity. Towards this goal, we approximately linearize the nonlinear terms of the factor graph (FG) messages in order to obtain a closed-form Gaussian solution of message updates. Accordingly, only the means and variances need to be updated and transmitted by the network nodes. Finally, we present the numerical results of each method and discuss their advantages and drawbacks. Considering time offsets of order ∼ 10−8 sec (10 nanosec) and a 50×50 m2 plane, with 50 agents and  9 anchors, simulations showed that the proposed cooperative GBP can provide quite accurate location estimates, just 0.8 m off from the real values, under 20 m communication range and a noise variance for ranging measurements of σd2 = 1 m2, utilizing the sequential method. Under the same circumstances, joint estimation in a non-cooperative environment demonstrates a slightly larger average error, ∼ 1 m, but lowers the communication requirements of  the network. In the joint non-cooperative case, the number of the messages that need to be exchanged is significantly reduced due to the lower number of neighbors per agent, since a circle of 20 m radius in a 50 × 50 m2 plane would contain much more agents than anchors, 15 − 20 and 5 – 7, on average, respectively.
PEGylated pH-responsive peptide-mRNA nano self-assemblies enhance the pulmonary delivery efficiency and safety of aerosolized mRNA
Creators: name: Xu, Yingying
name: Zheng, Yijing
name: Ding, Xuqiu
name: Wang, Chengyan
name: Hua, Bin
name: Hong, Shilian
name: Huang, Xiaoman
name: Lin, Jiali
name: Zhang, Peng
name: Chen, Wei
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biophysics
Biochemistry
Space Science
Medicine
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: Inhalable messenger RNA (mRNA) has demonstrated great potential in therapy and vaccine development to confront various lung diseases. However, few gene vectors could overcome the airway mucus and intracellular barriers for successful pulmonary mRNA delivery. Apart from the low pulmonary gene delivery efficiency, nonnegligible toxicity is another common problem that impedes the clinical application of many non-viral vectors. PEGylated cationic peptide-based mRNA delivery vector is a prospective approach to enhance the pulmonary delivery efficacy and safety of aerosolized mRNA by oral inhalation administration. In this study, different lengths of hydrophilic PEG chains were covalently linked to an amphiphilic, water-soluble pH-responsive peptide, and the peptide/mRNA nano self-assemblies were characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The in vitro mRNA binding and release, cellular uptake, transfection, and cytotoxicity were studied, and finally, a proper PEGylated peptide with enhanced pulmonary mRNA delivery efficiency and improved safety in mice was identified. These results showed that a proper N-terminus PEGylation strategy using 12-monomer linear monodisperse PEG could significantly improve the mRNA transfection efficiency and biocompatibility of the non-PEGylated cationic peptide carrier, while a longer PEG chain modification adversely decreased the cellular uptake and transfection on A549 and HepG2 cells, emphasizing the importance of a proper PEG chain length selection. Moreover, the optimized PEGylated peptide showed a significantly enhanced mRNA pulmonary delivery efficiency and ameliorated safety profiles over the non-PEGylated peptide and LipofectamineTM 2000 in mice. Our results reveal that the PEGylated peptide could be a promising mRNA delivery vector candidate for inhaled mRNA vaccines and therapeutic applications for the prevention and treatment of different respiratory diseases in the future. Schematic illustration of proper PEGylation strategy of pH-responsive LAH4-L1 peptide-mRNA nano self-assemblies enhances the pulmonary delivery efficiency of aerosolized mRNA.
Sustained delivery of triamcinolone acetonide from a thermosensitive microemulsion gel system for the treatment of sensorineural hearing loss
Creators: name: Nguyen, Thu Nhan
name: Yoo, So-Yeol
name: Tangchang, Warisraporn
name: Lee, Jae-Young
name: Son, Hwa-Young
name: Park, Jeong-Sook
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Space Science
Medicine
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: Intratympanic administration for the delivery of steroids has been extensively studied but limited because of low permeability of the drug through the row window membrane. Here, to effectively deliver poorly soluble triamcinolone acetonide (TA), microemulsions (ME) were prepared from Capmul MCM (oil), Cremophor RH40 (surfactant), and tetraglycol (cosurfactant) based on solubility studies, emulsifying ability test, and pseudoternary phase diagrams. Microemulsion gel (MEG) was prepared by mixing TA-ME with a poloxamer hydrogel base. The physicochemical properties of ME and MEG formulations were characterized, and the toxicity and oto-protective effectiveness were evaluated in vitro and in vivo. The ME-3 formulation showed a small droplet size (16.5 ± 0.2 nm), narrow PDI (0.067 ± 0.041), and enhanced TA solubility (2619.7 ± 57.6 μg/g). The optimized MEG demonstrated temperature-dependent gelation with a gelation time of 208 ± 10 sec at 37 °C. Slow degradation of the gel matrix sustained release of TA from MEG compared to the ME formulation. Both TA-ME and TA-MEG were found to be nontoxic to NIH3T3 cells at the test concentrations (0 to 5 µg/mL), and biocompatible after intratympanic administration to mice. The incorporation of ME into thermosensitive hydrogels prolonged retention of TA at the site of administration until 6 days. As a consequence, the enhanced drug absorption into the cochlea in TA-MEG group (approximately 2 times higher than other groups) protected hair cells, spiral ganglion neurons, and stria vascular cells from cisplatin-induced damage. Therefore, this injectable TA-loaded MEG is an effective and safe vehicle for the sustained delivery of triamcinolone acetonide into the inner ear.
Sonodynamic therapy of glioblastoma mediated by platelets with ultrasound-triggered drug release
Creators: name: Wang, Meiyao
name: Xu, Huazhen
name: Li, Tongfei
name: Li, Ke
name: Zhang, Quan
name: Chen, Siyi
name: Zhao, Li
name: Chen, Jincao
name: Chen, Xiao
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biophysics
Space Science
Medicine
Cell Biology
Neuroscience
Pharmacology
Biotechnology
Biological Sciences not elsewhere classified
Cancer
Hematology

description: Sonodynamic therapy (SDT) has aroused great interest for its potential in the treatment of glioblastoma (GBM). SDT relies on tumor-selective accumulation of a sonosensitizer that is activated by ultrasound irradiation (UI) to generate cytotoxic actions. The efficacy of GBM-SDT depends on sufficient sonosensitizer buildup in the tumor, which is, however, seriously hampered by the anatomical and biochemical barriers of the GBM. To overcome this difficulty, we herein propose a delivery strategy of ‘platelets with ultrasound-triggered release property’, which takes advantage of 1) the platelets’ ability to carry cargo and release cargo upon activation, and 2) the ROS-generating property of SDT. To provide proof of concept for the strategy, we first stably loaded platelets with IOPD-Ce6, a nano-formed sonosensitizer consisting of iron oxide nanoparticles coated with polyglycerol and doxorubicin and loaded with chlorine e6. UI of the IOPD-Ce6-loaded platelets (IOPD-Ce6@Plt) elicited ROS generation in the IOPD-Ce6@Plt, which were immediately activated to release IOPD-Ce6 into GBM cells in co-culture which, when subjected to a second time of UI, exhibited pronounced ROS production, DNA injury, viability loss, and cell death in the GBM cells. In the in vivo experiments, mice bearing intracranial GBM grafts exhibited substantial tumor distribution of IOPD-Ce6 following intravenous injection of IOPD-Ce6@Plt and subsequent UI at the tumor site. The GBM grafts then exhibited pronounced cell injury and death after another round of UI of the tumors. Finally, the growth of intra-cranial GBM grafts was significantly slowed when an SDT protocol consisting of an intravenous IOPD-Ce6@Plt injection followed by multiple times of tumor UI had been applied twice to the mice. Our results are strong evidence for the idea that platelets are sound and amenable carriers to deliver sonosensitizers in the GBM in an ultrasound-triggered manner and thus to produce highly targeted and effective SDT of GBM.