cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Dynamics of biological markets with multiple biosimilar competitors in the United States
Creators: name: Mouslim, Morgane C.
name: Socal, Mariana P.
name: Trujillo, Antonio J.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: The dynamics of biological markets with multiple biosimilar competitors in the United States are poorly understood. Moreover, due to confidentiality issues, the relationship between originator biologic net prices, rebates, and biosimilar entry is largely unexplored. We conducted a review of the Food Drug Administration (FDA) purple book and manufacturer websites to identify all originator biologics with multiple competitors and their characteristics. We leveraged a novel data source to examine originator biologic net prices and rebates over time and used descriptive statistics and interrupted time-series analyses to assess their relationship with biosimilar entry. By December 2022, only five originator biologics had three or more available biosimilar competitors. Mean time between biosimilar approval and biosimilar launch was 9 months (SD = 7.04 months). By third biosimilar competitor, entry net prices for originator biologics had decreased by 9.34% to 50.93%, while rebates had increased by 25.35% to 89.71%. Very few originator biologics have multiple available biosimilar competitors. Barrier to biosimilar availability seems to be at the approval level as the time between approval and launch is relatively short. However, originator biologics respond quickly to biosimilar competition, mainly through an increase in rebates.
Additional file 4: of Objectively measured physical activity and sedentary time in youth: the International childrenâ  s accelerometry database (ICAD)
Creators: name: Cooper, Ashley
name: Goodman, Anna
name: Page, Angie
name: Sherar, Lauren
name: Esliger, Dale
name: Sluijs, Esther Van
name: Andersen, Lars
name: Anderssen, Sigmund
name: Cardon, Greet
name: Davey, Rachel
name: Froberg, Karsten
name: Hallal, Pedro
name: Janz, Kathleen
name: Kordas, Katarzyna
name: Kreimler, Susi
name: Pate, Russ
name: Jardena Puder
name: Reilly, John
name: Salmon, Jo
name: Sardinha, Luis
name: Timperio, Anna
name: Ekelund, Ulf
Publisher: name: Figshare
Year: 2015
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy

description: Avon Longitudinal Study of Parents and Children (ALSPAC). (DOC 27 kb)
Co-opting Equity: Advancing a Neoliberal Agenda in Manitoba Education Reforms
Creators: name: Bees, Ellen
Publisher: name: Critical Education
Year: 2024

description: This paper uses critical policy analysis to investigate how the concept of equity has been co-opted to promote a neoliberal agenda in education reforms in Manitoba. Early provincial reform documents contained a narrow definition of equity focused primarily on closing achievement gaps between Indigenous and non-Indigenous students. These reform documents were rejected by the public, in part due to concerns about equity. The Manitoba Education Action Plan was introduced in 2022, which more explicitly focused on achieving equity as part of the education reform process. However, the framing of equity in the Action Plan was narrow, emphasizing individualism rather than a more systemic pursuit of equity. While some recommended actions in the Action Plan have promoted a more inclusive and culturally responsive education system, other actions have advanced a neoliberal agenda focused on work-readiness and accountability, while actions to remove barriers to education have been undertaken with limited urgency.
description: Critical Education, Vol. 15 No. 2 (2024): Defending and Strengthening Public Education as a Common Good
Additional file 1: Table S1. of How and how much does RAD-seq bias genetic diversity estimates?
Creators: name: Cariou, Marie
name: Duret, Laurent
name: Charlat, Sylvain
Publisher: name: Figshare
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology

description: Genomic sequences used for the in silico RAD-seq experiments. 2. Polymorphism heterogeneity along the genome of Schizophyllum commune. Figure S1. Theoretical and observed distributions of genetic distances (number of SNPs between RAD tags) between two American S. commune individuals (A10 and A13, on the left) and between 2 Russian individuals (K1 and K3, on the right). Blue: observed distribution of genetic distances; red: Poisson distribution, expected under a model of homogeneous polymorphism along the genome. Kolmogorov-Smirnov test, D = 0.2404, p-value
MOESM4 of Targeted bisulfite sequencing of the dynamic DNA methylome
Creators: name: Ziller, Michael
name: Stamenova, Elena
name: Hongcang Gu
name: Gnirke, Andreas
name: Meissner, Alexander
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Plant Biology

description: Additional file 4: Figure S3 a. Heatmap and clustering of all GTEx samples based on the Pearson correlation coefficient (PCC) across the methylation levels of the union of all differentially methylated regions between any of the samples. Figure S3b. Pie chart showing the number of differentially methylated 200-bp tiles identified across all GTEx samples, those that arise in addition when adding DyMe-Seq data for hESCs (HUES64) and those that still remain static.
Additional file 3: of Hyperhomocysteinemia induced by excessive methionine intake promotes rupture of cerebral aneurysms in ovariectomized rats
Creators: name: Korai, Masaaki
name: Kitazato, Keiko
name: Yoshiteru Tada
name: Miyamoto, Takeshi
name: Shimada, Kenji
name: Matsushita, Nobuhisa
name: Kanematsu, Yasuhisa
name: Satomi, Junichiro
name: Hashimoto, Tomoki
name: Nagahiro, Shinji
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Evolutionary Biology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Marine Biology

description: Plasma homocysteine level and systolic blood pressure. (PDF 35Â kb)
Additional file 1: of Hyperhomocysteinemia induced by excessive methionine intake promotes rupture of cerebral aneurysms in ovariectomized rats
Creators: name: Korai, Masaaki
name: Kitazato, Keiko
name: Yoshiteru Tada
name: Miyamoto, Takeshi
name: Shimada, Kenji
name: Matsushita, Nobuhisa
name: Kanematsu, Yasuhisa
name: Satomi, Junichiro
name: Hashimoto, Tomoki
name: Nagahiro, Shinji
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Evolutionary Biology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Marine Biology

description: Systolic blood pressure and body weight. (PDF 78Â kb)
Dynamics of biological markets with multiple biosimilar competitors in the United States
Creators: name: Mouslim, Morgane C
name: Socal, Mariana P
name: Trujillo, Antonio
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: The dynamics of biological markets with multiple biosimilar competitors in the United States are poorly understood. Moreover, due to confidentiality issues, the relationship between originator biologic net prices, rebates and biosimilar entry is largely unexplored. We conducted a review of the Food Drug Administration (FDA) purple book and manufacturer websites to identify all originator biologics with multiple competitors and their characteristics. We leveraged a novel data source to examine originator biologic net prices and rebates over time and used descriptive statistics and interrupted time series analyses to assess their relationship with biosimilar entry. By December 2022, only five originator biologics had three or more available biosimilar competitors. Mean time between biosimilar approval and biosimilar launch was 9 months (SD = 7.04 months). By third biosimilar competitor entry net prices for originator biologics had decreased by 9.34% to 50.93% while rebates had increased by 25.35% to 89.71%. Very few originator biologics have multiple available biosimilar competitors. Barrier to biosimilar availability seems to be at the approval level as time between approval and launch is relatively short. However, originator biologics respond quickly to biosimilar competition, mainly through an increase in rebates.
MOESM3 of Targeted bisulfite sequencing of the dynamic DNA methylome
Creators: name: Ziller, Michael
name: Stamenova, Elena
name: Hongcang Gu
name: Gnirke, Andreas
name: Meissner, Alexander
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Plant Biology

description: Additional file 3: Figure S2 a. Distribution of CpG level read coverage (x-axis) across 4 technical replicates of DyMe-Seq at different mean coverage levels indicated (e.g. R1, c=36.2, indicating a mean CpG coverage of 36.2 reads). Figure S2b. Distribution of the observed fraction of GC content across 200-bp tiles of the target DyMe-Seq capture set across 4 technical replicates of DyMe-Seq (R1-R4) at different mean coverage levels (see Figure S2a.) and the expected percentage based on analysis of target capture set. Figure S2c. Percentage of duplicate reads as a function of genomic DNA input in nanogram for DyMe-Seq using a standard “adapter-ligation first” library preparation method (KAPA). Error bars indicate standard error/range based on n≥2. Figure S2d. Percentage of duplicate reads as a function of genomic DNA input in nanogram for DyMe-Seq using a “bisulfite first” library preparation protocol (Swift). Error bars indicate standard error/range based on n≥2. Figure S2e. On-target rate for three independent DyMe-Seq experiments. On-target rate is defined as on and near (±250) bait bases divided by the number of passing filter bases aligned. Figure S2f. On-target rate for all DyMe-Seq experiments conducted in this study, giving a median On-target rate of 70.3%. Figure S2g. Left: Distribution of methylation level differences between two biological replicates of hESC WGBS dataset (y-axis) as a function of the methylation level in WGBS replicate R1 (x-axis) across 200-bp tiles of the DyMe-Seq target capture set. Right: This panel depicts the same distribution type of distribution as on the left, but now shows the methylation level differences between WGBS replicate R1 and a DyMe-Seq dataset for a different biological replicate of hESCs, again condition on the methylation level in WGBS hESC replicate 1.
Additional file 1: of Selected static foot assessments do not predict medial longitudinal arch motion during running
Creators: name: Langley, Ben
name: Cramp, Mary
name: Morrison, Stewart
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Science Policy

description: Medial longitudinal arch calculation rationale and supporting data. (DOCX 1365 kb)
The Temperature versus Orbital Period relation of AM CVns: Insights from their Donors
Creators: name: Macrie, Colin W.
name: Sandoval, Liliana Rivera
name: Cavecchi, Yuri
name: Wong, Tin Long Sunny
name: Marcano, Manuel Pichardo
Publisher: name: arXiv
Year: 2024
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We studied the spectral energy distribution (SED) of 22 known AM~CVns with orbital periods ($P_{orb}$) larger than 35~min using multiwavelength public photometric data to estimate the effective temperature of the accreting white dwarf. We find an infrared (IR) excess in all systems when compared to a single blackbody, both when the disk should be extended and when it should be truncated by the accretor's magnetic field. This suggests a dominant contribution from the donor to the IR flux. When fitting two blackbodies, the temperature of the hot component decreases with $P_{orb}$, as expected by evolutionary models. Temperatures for systems with $35
description: 3 Pages, 1 Figure, Published RNAAS
A systematic review of the efficacy and safety of anti-amyloid beta monoclonal antibodies in treatment of Alzheimer’s disease
Creators: name: Chhabra, Akanksha
name: Solanki, Siddhant
name: Saravanabawan, Prithvi
name: Venkiteswaran, Arun
name: Nimmathota, NagaTarang
name: Modi, Nishi Manojkumar
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Mental Health

description: Alzheimer’s disease can cause dementia through brain matter degradation. This study investigates the monoclonal antibody usage for AD treatment, following PRISMA 2020 guidelines, and aims to discern the monoclonal antibody that offers the optimal balance of efficacy and safety for individuals with AD. A systematic search was conducted across databases such as PubMed, Cochrane Library, and clinical trial registries for randomized controlled trials. The quality of studies was assessed using the Cochrane risk of bias 2 tool. Cognitive function and daily activities were evaluated using MMSE, ADAS-Cog, and CDR-SB test data. According to CDR-SB measurements, lecanemab showed effectiveness in reducing brain amyloid and cognitive decline, with a change from baseline of 1.21. Aducanumab resulted in a decrease of -0.39 (-22%). Bapineuzumab showed no significant benefit, with scores of 2.4 (2.8). Gantenerumab, scoring 1.69 (1.37, 2.01), reduces amyloid, particularly in early Alzheimer’s stages. Crenezumab was ineffective, with a score of 3.61. The findings provide various perspectives. Lecanemab showed the most promise in brain amyloid reduction and decelerating cognitive decline compared to the other therapies. Further research is needed, highlighting the necessity of AD therapeutic research to alter AD’s trajectory and provide reliable treatment. www.crd.york.ac.uk/prospero identifier is CRD42024504358 This study investigates the safety and efficacy of treating Alzheimer’s disease (AD) with monoclonal antibodies. In order to determine which antibody could be most helpful, we looked over a number of trials. Several antibodies, such as lecanemab, solanezumab, aducanumab, bapineuzumab, gantenerumab, and crenezumab, were the subject of the study. According to our research, lecanemab is particularly effective at lowering brain amyloid plaques and delaying cognitive deterioration, two major problems associated with Alzheimer’s disease. Other antibodies, such as solanezumab and bapineuzumab, had little to no beneficial effects, making their benefits less evident. The contradictory results of aducanumab indicate that further research is necessary to ascertain its actual efficacy. When administered at the earliest stages of Alzheimer’s disease or when used at a higher dose, crenezumab may be beneficial. Even though lecanemab seems promising, research in this field is still in its infancy. To validate these results and get further insight into the potential applications of these medicines in the management of Alzheimer’s disease, additional research is required. In summary, this study emphasizes the necessity of ongoing research to discover trustworthy treatments for AD patients.
Dublin Descriptors
Creators: name: Masaev, Sergey
name: Dorrer, Georgiy
name: Vingert, Valentina
name: Yakimova, Elena
name: Klochkov, Svatoslav
Publisher: name: arXiv
Year: 2024
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics
subject: H.1

description: Dublin descriptors are under consideration. It is part of one of the global integration processes between European countries and Russia, which began in 1999. It causes a lot of controversy and approval from different sides. For the sake of clarity, an assessment is being made of the industrial application of the Dublin Descriptors. The assessment is based on the method of integral indicators. To use the method, the enterprise is formalized as a model of events at each moment in time. Each event in the enterprise is tied to the student's skill. Accordingly, students' skills are grouped by educational level. Education levels are given as Dublin descriptors. The chosen approach makes it possible to determine the correlation between levels of education and skills. It makes it possible to analyze meaningful interconnection. A universal assessment of the use of Dublin descriptors in the enterprise allows the formation of up-to-date lists of employees for higher education, professional development and training.
Ercolania Trinchese 1872
Creators: name: Wägele, Heike
name: Stemmer, Kristina
name: Burghardt, Ingo
name: Händeler, Katharina
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Sacoglossa
Limapontiidae
Ercolania

description: Ercolania Trinchese, 1872
Type species: Ercolania siotii Trinchese, 1872, by subsequent designation (Iredale & O’Donoghue 1923).
Diagnosis. According to Baba and Hamatani (1970), Schmekel and Portmann (1982) and Jensen (1985, 1993), the genus Ercolania is characterized by the following features: Presence of cerata, which are fusiform or inflated; digitiform rhinophores, which are circular or slightly flattened in cross-section; elongate or inconspicuous reno-pericardial prominence; presence of sabot-shaped teeth; presence of a curved penial stylet; probably absence of albumen gland in the cerata.
description: Published as part of Wägele, Heike, Stemmer, Kristina, Burghardt, Ingo & Händeler, Katharina, 2010, Two new sacoglossan sea slug species (Opisthobranchia, Gastropoda): Ercolania annelyleorum sp. nov. (Limapontioidea) and Elysia asbecki sp. nov. (Plakobranchoidea), with notes on anatomy, histology and biology, pp. 1-28 in Zootaxa 2676 on page 5, DOI: 10.5281/zenodo.199203
Additional file 4: of Gentisic acid sodium salt, a phenolic compound, is superior to norepinephrine in reversing cardiovascular collapse, hepatic mitochondrial dysfunction and lactic acidemia in Pseudomonas aeruginosa septic shock in dogs
Creators: name: Mink, Steven
name: Chowdhury, Subir Roy
name: Gotes, Jose
name: Zhao-Qin Cheng
name: Krika Kasian
name: Fernyhough, Paul
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: Table S3. Selective blood and hematology parameters in the septic control group (n = 13). (DOC 40 kb)
Online controller optimization for a voltage-doubler boost rectifier with high power factor
Creators: name: Bayona, Jhon
name: Gélvez, Nancy
name: Espitia, Helbert
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Computational Biology

description: The design of converters is essential for the proper use of electrical energy. Half-bridge topology represents a suitable conversion scheme to implement a boost rectifier converter. Consequently, this article proposes the parameter optimization of a proportional-integral-derivative (with filter) controller for a half-bridge boost rectifier with a high power factor. Regarding the high simulation time for the converter, stochastic hill-climbing and simulated annealing algorithms are employed for the optimization process. The results display that the optimized controller allows suitable values for the power factor and output waveform. The controller parameters obtained through optimization algorithms result in a high power factor of 0.9934 when the half-bridge boost rectifier is operating at full load.
MOESM2 of LEAFDATA: a literature-curated database for Arabidopsis leaf development
Creators: name: Dรณra Szakonyi
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Additional file 2: Table S1. Number of results retrieved by keywords search using different terms for large-leaf phenotype.
Imperialist competition algorithm with quasi-opposition-based learning for function optimization and engineering design problems
Creators: name: Lei, Dongge
name: Cai, Lulu
name: Wu, Fei
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Space Science
Biotechnology
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified

description: Imperialist competitive algorithm (ICA) is an efficient meta-heuristic algorithm by simulating the competitive behaviour among imperialist countries. However, it still suffers from slow convergence and deficiency in exploration. To address these issues, an improved ICA is proposed by combining ICA with a quasi-opposition-based learning (QOBL) strategy, which is named QOBL-ICA. The improvements include two aspects. First, the QOBL strategy is adopted to generate a population of fitter individuals. Second, a QOBL-assisted assimilation strategy is proposed to enhance the exploration ability of ICA. As a result, the proposed QOBL-ICA has more powerful exploration ability than ICA as well as faster convergence speed. The effectiveness of the proposed QOBL-ICA is verified by testing on 20 benchmark functions and 3 engineering design problems. Experimental results show that the performance of QOBL-ICA is superior to most state-of-the-art meta-heuristic algorithms in terms of global optimum reached and convergence speed.
НАРУШЕНИЕ ПСИХИЧЕСКИХ ФУНКЦИЙ У ЭКСПЕРИМЕНТАЛЬНЫХ КРЫС ПРИ ГИПЕРТИРЕОЗЕ
Creators: name: Раджабова, Феруза
name: Джаббарова, Г.М.
Publisher: name: Zenodo
Year: 2024

description: Известно, что гипертиреоз характеризуется усиленными метаболическими процессами и повышенными уровнями свободных тиреоиднных гормонов в сыворотке крови. Симптоматика данной патологии включает сердцебиение, утомляемость, потерю веса, непереносимость жары, тревогу и тремор. Диагностика основана как на клинических проявлениях, так и результатах лабораторной оценки функции щитовидной железы. Коррекция во многом зависит от течения заболевания.
Additional file 1: of Pharmacological strategies to reduce exacerbation risk in COPD: a narrative review
Creators: name: Miravitlles, Marc
name: DâUrzo, Anthony
name: Singh, Dave
name: Koblizek, Vladimir
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Supplementary material. Table S1. Comparison of guidelines and recommendations definitions of exacerbations of COPD. Table S2. Comparison of guidelines and recommendations assessment of exacerbation risk. (DOCX 30Â kb)
Additional file 4: Table S3. of Genetic differentiation over a small spatial scale of the sand fly Lutzomyia vexator (Diptera: Psychodidae)
Creators: name: Neal, Allison
name: Ross, Max
name: Schall, Jos
name: Vardo-Zalik, Anne
Publisher: name: Figshare
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology
subject: Computational Biology

description: Results from a statistical test for linkage disequilibrium for eight Lutzomyia vexator loci. * indicates P  0.0018. (DOCX 13 kb)
Contrast enhancement of digital images using dragonfly algorithm
Creators: name: Saha, Soumyajit
name: Chatterjee, Somnath
name: Sen, Shibaprasad
name: Oliva, Diego
name: Perez-Cisneros, Marco
name: Sarkar, Ram
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Space Science
Medicine
Neuroscience
Pharmacology
Information Systems not elsewhere classified

description: Contrast enhancement aims to amplify the visual quality of images by modifying the contrast level because digital images may get distorted by casual acquisition. The article deals with contrast enhancement as an optimization problem and uses the Dragonfly Algorithm (DA) to find the optimal grey-level intensity values. The DA for contrast enhancement uses five control parameters (entropy, number of edges, total intensities of edges, the variance of the probability of occurrence of each grey value, and the number of grey levels) to generate an objective function. An ablation study is also performed to understand how different controlling parameter combinations contribute to determining the optimal solution. The proposed approach considers 24 grey-scale images from the Kodak dataset and metrics as Peak Signal-to-Noise Ratio (PSNR), Visual Information Fidelity (VIF), and Structural Similarity Index Measure (SSIM) to verify the output's performance. The PSNR, VIF, and SSIM values in the experiments are 30.87, 0.7451, and 0.9523, respectively. The experimental observations reveal that the proposed DA-based image contrast enhancement produces high-quality images from its low-contrast counterparts. Comparisons with state-of-art methods ensure the superiority of the proposed algorithm. The Python implementation of the proposed approach is available in this Github repository.
Additional file 4: Figure S1. of CD49d is a disease progression biomarker and a potential target for immunotherapy in Duchenne muscular dystrophy
Creators: name: Pinto-Mariz, Fernanda
name: Carvalho, Luciana Rodrigues
name: Araujo, Alexandra Prufer De Queiroz Campos
name: Mello, Wallace De
name: MĂĄrcia GonĂ§Alves Ribeiro
name: Cunha, Maria
name: Cabello, Pedro
name: Riederer, Ingo
name: Negroni, Elisa
name: Desguerre, Isabelle
name: Veras, Mariana
name: Yada, Erica
name: Allenbach, Yves
name: Benveniste, Olivier
name: Voit, Thomas
name: Mouly, Vincent
name: Silva-Barbosa, Suse
name: Butler-Browne, Gillian
name: Savino, Wilson
Publisher: name: Figshare
Year: 2015
Subjects: subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Computational Biology

description: Gating procedures for cytofluorometric labeling of CD49d in freshly isolated leukocytes from the blood of normal subjects and Duchenne muscular dystrophy patients. (DOC 108 kb)
Additional file 3: Table S3. of The impact of increasing income inequalities on educational inequalities in mortality - An analysis of six European countries
Creators: name: Hoffmann, Rasmus
name: Yannan Hu
name: Gelder, Rianne De
name: Menvielle, Gwenn
name: Bopp, Matthias
name: Mackenbach, Johan
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Sensitivity analysis comparing all-cause and non-smoking related mortality. (DOCX 12Â kb)
Additional file 2: Table S2. of A pilot cohort study of cerebral autoregulation and 2-year neurodevelopmental outcomes in neonates with hypoxic-ischemic encephalopathy who received therapeutic hypothermia
Creators: name: Burton, Vera
name: Gerner, Gwendolyn
name: Cristofalo, Elizabeth
name: Shang-En Chung
name: Jennings, Jacky
name: Charlamaine Parkinson
name: Koehler, Raymond
name: Chavez-Valdez, Raul
name: Johnston, Michael
name: Northington, Frances
name: Lee, Jennifer
Publisher: name: Figshare
Year: 2015
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Marine Biology
subject: Science Policy

description: Blood pressure in relation to the optimal mean arterial blood pressure and the Mullen score. (DOC 49Â kb)
Elysia Risso 1818
Creators: name: Wägele, Heike
name: Stemmer, Kristina
name: Burghardt, Ingo
name: Händeler, Katharina
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Sacoglossa
Plakobranchidae
Elysia

description: Elysia Risso, 1818
Type species: Notarchus timidus Risso, 1818, by monotypy.
Comments and diagnosis. In spite of several older diagnoses of the genus, Jensen (1996) could not identify any apomorphic characters which are shared by all species referred to the genus Elysia, and this is still valid. Nevertheless, recent phylogenetic analyses based on several molecular markers (Händeler et al. 2009) indicate the monophyly of the genus Elysia. We refer here to one of the most recent descriptions (Jensen 1993) indicating the most prominent character for Elysia: pharynx without pharyngeal pouches (although this is shared by many sacoglossan genera, except within the Plakobranchoidea). Furthermore Elysia species are described with long blade-shaped radular teeth with a median denticulate cutting edge (Bouchet 1984; Thompson & Jaklin, 1988; Gosliner 1995) and broad parapodia (Thompson 1973).
description: Published as part of Wägele, Heike, Stemmer, Kristina, Burghardt, Ingo & Händeler, Katharina, 2010, Two new sacoglossan sea slug species (Opisthobranchia, Gastropoda): Ercolania annelyleorum sp. nov. (Limapontioidea) and Elysia asbecki sp. nov. (Plakobranchoidea), with notes on anatomy, histology and biology, pp. 1-28 in Zootaxa 2676 on page 16, DOI: 10.5281/zenodo.199203
Additional file 5: Figure S2. of CD49d is a disease progression biomarker and a potential target for immunotherapy in Duchenne muscular dystrophy
Creators: name: Pinto-Mariz, Fernanda
name: Carvalho, Luciana Rodrigues
name: Araujo, Alexandra Prufer De Queiroz Campos
name: Mello, Wallace De
name: MĂĄrcia GonĂ§Alves Ribeiro
name: Cunha, Maria
name: Cabello, Pedro
name: Riederer, Ingo
name: Negroni, Elisa
name: Desguerre, Isabelle
name: Veras, Mariana
name: Yada, Erica
name: Allenbach, Yves
name: Benveniste, Olivier
name: Voit, Thomas
name: Mouly, Vincent
name: Silva-Barbosa, Suse
name: Butler-Browne, Gillian
name: Savino, Wilson
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer

description: Lack of differences between DMD patients and healthy control in relative numbers of CD14/CD49dhi and CD19/CD49dhi cells. (DOC 69 kb)
title: Kinetic study of H-terminated silicon nanowires oxidation in very first stages
Creators: name: Bashouti, Muhammad Y.
name: Sardashti, Kasra
name: Ristein, Jürgen
name: Christiansen, Silke H.
Publisher: name: Freie Universität Berlin
Year: 2013
Subjects: subject: Silicon nanowires
subject: Oxidation
subject: Kinetics
subject: Activation energy
classificationCode: 530
subject: Physik

description: Oxidation of silicon nanowires (Si NWs) is an undesirable phenomenon that has a detrimental effect on their electronic properties. To prevent oxidation of Si NWs, a deeper understanding of the oxidation reaction kinetics is necessary. In the current work, we study the oxidation kinetics of hydrogen- terminated Si NWs (H-Si NWs) as the starting surfaces for molecular functionalization of Si surfaces. H-Si NWs of 85-nm average diameter were annealed at various temperatures from 50°C to 400°C, in short-time spans ranging from 5 to 60 min. At high temperatures (T ≥ 200°C), oxidation was found to be dominated by the oxide growth site formation (made up of silicon suboxides) and subsequent silicon oxide self-limitation. Si-Si backbond oxidation and Si-H surface bond propagation dominated the process at lower temperatures (T < 200°C).
Novel role of autophagy-associated Pik3c3 gene in gonadal white adipose tissue browning in aged C57/Bl6 male mice
Creators: name: Ghosh, AK
name: Mau, T
name: O'Brien, M
name: Yung, R
Publisher: name: Impact Journals, LLC
Year: 2018
Subjects: ER-Stress
adipose tissue
aging
autophagy
inflammation
Adipose Tissue, Brown
Adipose Tissue, White
Adiposity
Aging
Animals
Autophagy
Class III Phosphatidylinositol 3-Kinases
Endoplasmic Reticulum Stress
Inflammation
Male
Mice
Mice, Inbred C57BL
Mice, Knockout

description: Adipose tissue dysfunction is associated with inflammation, metabolic syndrome and other diseases in aging. Recent work has demonstrated that compromised autophagy activity in aging adipose tissue promotes ER stress responses, contributing to adipose tissue and systemic inflammation in aging. Phosphatidylinositol 3- kinase catalytic subunit type 3 (Pik3c3) is an 887 amino acid lipid kinase that regulates intracellular membrane trafficking and autophagy activity. To address the mechanistic link between autophagy and ER stress response in aging adipose tissue, we generated a line of adipose tissue-specific Pik3c3 knock out (~mutant mice) with the Fabp4 (Fatty acid binding protein 4) promoter driven Cre recombinase system. We found elevated ER stress response signaling with reduced autophagy activity without any significant change on adiposity or glucose tolerance in early life of Pik3c3 mutant mice. Interestingly, middle- and old-aged mutant mice exhibited improved glucose tolerance (GTT) and reduced adiposity compared to age and sex-matched littermates. In addition, adipose tissue-specific Pik3c3 mutants display reduced expression of adiposity-associated genes with the signature of adipose tissue browning phenotypes in old age. Overall, the results suggest that altered adipose tissue characteristics due to autophagy inhibition early in life has beneficial effects that promote adipose tissue browning and improves glucose tolerance in late-life.
Polygenic risk score analysis reveals shared genetic burden between epilepsy and psychiatric comorbidities
Creators: name: Campbell, C.
name: Lewis-Smith, D.
name: Leu, C.
name: Martins, H.
name: Wolking, Stefan
name: Krause, R.
name: O'Brien, T.
name: Sill, G.
name: Zara, F.
name: Koeleman, B.
name: Depondt, C.
name: Marson, A.
name: Stefánnson, H.
name: Stefánnson, K.
name: Craig, J.
name: Johnson, M. R.
name: Striano, P.
name: Jorgensen, A.
name: Lerche, H.
name: Delanty, N.
name: The EpiPGX Consortium
name: Sisodiya, S. M.
name: Thomas, R. H.
name: Cavalleri, G. L.
Publisher: name: RWTH Aachen University
Year: 2023

description: 28 Seiten (2023). doi:10.1101/2023.07.04.23292071
Additional file 2: Table S2. of The impact of increasing income inequalities on educational inequalities in mortality - An analysis of six European countries
Creators: name: Hoffmann, Rasmus
name: Yannan Hu
name: Gelder, Rianne De
name: Menvielle, Gwenn
name: Bopp, Matthias
name: Mackenbach, Johan
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Plant Biology
subject: FOS: Biological sciences

description: Correlation coefficients between country-specific trends in inequality in mortality and country-specific trends in income inequality. (DOCX 12Â kb)
Tracing North Atlantic volcanism and seaway connectivity across the Paleocene–Eocene Thermal Maximum (PETM)
Creators: name: Jones, Morgan T.
name: Stokke, Ella W.
name: Rooney, Alan D.
name: Frieling, Joost
name: Pogge von Strandmann, Philip A. E.
name: Wilson, David J.
name: Svensen, Henrik H.
name: Planke, Sverre
name: Adatte, Thierry
name: Thibault, Nicolas R.
name: Vickers, Madeleine L.
name: Mather, Tamsin A.
name: Tegner, Christian
name: Zuchuat, Valentin
name: Schultz, Bo P.
Publisher: name: RWTH Aachen University
Year: 2023

description: 53 Seiten (2023). doi:10.5194/egusphere-2023-36
Additional file 1: Table S1. of CD49d is a disease progression biomarker and a potential target for immunotherapy in Duchenne muscular dystrophy
Creators: name: Pinto-Mariz, Fernanda
name: Carvalho, Luciana Rodrigues
name: Araujo, Alexandra Prufer De Queiroz Campos
name: Mello, Wallace De
name: MĂĄrcia GonĂ§Alves Ribeiro
name: Cunha, Maria
name: Cabello, Pedro
name: Riederer, Ingo
name: Negroni, Elisa
name: Desguerre, Isabelle
name: Veras, Mariana
name: Yada, Erica
name: Allenbach, Yves
name: Benveniste, Olivier
name: Voit, Thomas
name: Mouly, Vincent
name: Silva-Barbosa, Suse
name: Butler-Browne, Gillian
name: Savino, Wilson
Publisher: name: Figshare
Year: 2015
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 60506 Virology

description: General characteristics of the DMD patients enrolled in the study of blood samples. (DOC 35 kb)
Additional file 1: Table S1. of The impact of increasing income inequalities on educational inequalities in mortality - An analysis of six European countries
Creators: name: Hoffmann, Rasmus
name: Yannan Hu
name: Gelder, Rianne De
name: Menvielle, Gwenn
name: Bopp, Matthias
name: Mackenbach, Johan
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Annual changes of absolute and relative inequalities in cause-specific mortality. (DOCX 14Â kb)
Online review analysis-based multi-criteria decision-making for evaluating patient satisfaction: A case study of the Haodf website
Creators: name: Chen, Zi-yu
name: Xiao, Fei
name: Wang, Yi-ting
name: Wang, Ya-nan
name: Hou, Wen-hui
name: Wang, Jian-qiang
name: Li, Lin
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: The online reviews provided by patients contain many aspects of patient satisfaction (PS). An accurate understanding of PS can help hospitals and doctors quickly find the direction of medical service improvement and help patients select appropriate doctors. However, online reviews are texts in which patients show true feelings without constraints. Therefore, identifying, measuring, and representing PS are difficult. To solve these problems, we propose the online review analysis-based multi-criteria decision-making (MCDM) method. First, an aspect extraction method integrating dependency parsing and attention-based aspect extraction (ABAE) is proposed, and nine criteria for PS evaluation are extracted from the online reviews of the Haodf website. Second, a sentiment analysis method based on multiple dictionaries and dependency relations is developed to measure PS under each criterion in reviews. Then, an MCDM method based on a probabilistic linguistic term set representing PS is used to assess PS when considering patients’ loss aversion. Finally, the proposed method is verified in the evaluation of lung cancer patients’ satisfaction with doctors. The results show that our extracted criteria have higher coherence and accuracy compared to those extracted by other aspect extraction methods, and the proposed online review analysis-based MCDM method outperforms state-of-the-art methods in PS identification, measurement, and representation.
GNSS/Multi-Sensor Fusion Using Continuous-Time Factor Graph Optimization for Robust Localization
Creators: name: Zhang, Haoming
name: Chen, Chih-Chun
name: Vallery, Heike
name: Barfoot, Timothy D.
Publisher: name: RWTH Aachen University
Year: 2023
Subjects: subject: FOS: Computer and information sciences
subject: FOS: Computer and information sciences
subject: Robotics (cs.RO)

description: 18 Seiten (2023). doi:10.48550/arXiv.2309.11134
Amphimedon Duchassaing & Michelotti 1864
Creators: name: Santos, George Garcia
name: Docio, Loyana
name: Pinheiro, Ulisses
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Porifera
Demospongiae
Haplosclerida
Niphatidae
Amphimedon

description: Genus Amphimedon Duchassaing & Michelotti, 1864
Definition: Niphatidae with an optically smooth surface, regular tangential ectosomal network with rounded meshes of a single size. Ends of choanosomal longitudinal primary fibers barely protruding. Spongin abundant. Microscleres absent (Desqueyroux-Faúndez & Valentine 2002).
Type species: Amphimedon compressa Duchassaing & Michelotti, 1864 (by subsequent designation, de Laubenfels 1936).
description: Published as part of Santos, George Garcia, Docio, Loyana & Pinheiro, Ulisses, 2014, Two new species of the family Niphatidae van Soest, 1980 from Northeastern Brazil (Haplosclerida: Demospongiae: Porifera), pp. 265-274 in Zootaxa 3774 (3) on page 266, DOI: 10.11646/zootaxa.3774.3.3, http://zenodo.org/record/225014
Multi-objective optimization of the auto-carrier loading and routing problem in an automotive logistics company
Creators: name: Yuan, Biao
name: Lu, Yuwei
name: Wang, Kangzhou
name: Peng, Xiaoshuai
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Information Systems not elsewhere classified
Mathematical Sciences not elsewhere classified

description: This paper presents a real-world auto-carrier loading and routing problem encountered by an automotive logistics company in China. The problem requires determining a set of routes for auto-carriers to transport vehicles from warehouses to dealers subject to several loading and routing constraints. Four objectives are considered, including the maximization of the number of loaded urgent vehicles and the number of loaded vehicles, and the minimization of the number of visits to dealers and travel distance. To solve such a multi-objective problem, we develop a two-stage iterated local search heuristic with the lexicographic optimization principle. Expressly, we assume that all vehicles are stored in one warehouse and solve the resulting problem as the first stage. Then the best-found solution is improved by considering the multiple warehouse constraints in the second stage. The effectiveness of the proposed heuristic is validated by comparing it with a commercial solver and the company’s approach. Moreover, computational results provide managerial insights for decision-makers when considering the objectives and their priorities in different scenarios.
Investigation of the FCNC couplings between the top quark and the photon in $γγ$ and $γ^{*}γ^{*}$ collisions at the CLIC
Creators: name: Alici, Eda
Publisher: name: arXiv
Year: 2024
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The investigation of flavour-changing neutral current transitions(FCNC) involving the top quark are only possible with new theoretical frameworks that extend the Standard Model(SM), given that these transitions are almost entirely suppressed within the SM. In this regard, examining these transitions with extended theories beyond the SM may provide significant insights into future experiments. To this end, we present a phenomological study about the anomalous FCNC transitions via $tqγ$ couplings with effective field theory. Here, ${γγ}{\rightarrow} {\textit{l}} ν_\textit{l} b \bar{q} $ , ${e^{+}} {e^{-}} {\rightarrow} {e^{+}} γ^{} γ^{} {\rightarrow} {e^{+}} \textit{l}{} {ν_\textit{ l}} b \bar{q} {e^{-}} $, $γγ{\rightarrow} j \bar{j} b \bar{q} $ and ${e^{+}} {e ^{-}} {\rightarrow} {e^{+}} γ^{} γ^{} {e^{-}} {\rightarrow}{e^{+}} j \bar{j} b \bar{q} {e^{-}} $ processes are investigated for the CLIC at $\sqrt{s} =1.5$TeV and 3 TeV. Thus, we have calculated the constraints at $95{\%}$ confidence level on the $BR(t\rightarrow qγ)$. As a result, the obtained constraints are at least one order of magnitude better than the available experimental ones.
Additional file 1: Table S1. of A pilot cohort study of cerebral autoregulation and 2-year neurodevelopmental outcomes in neonates with hypoxic-ischemic encephalopathy who received therapeutic hypothermia
Creators: name: Burton, Vera
name: Gerner, Gwendolyn
name: Cristofalo, Elizabeth
name: Shang-En Chung
name: Jennings, Jacky
name: Charlamaine Parkinson
name: Koehler, Raymond
name: Chavez-Valdez, Raul
name: Johnston, Michael
name: Northington, Frances
name: Lee, Jennifer
Publisher: name: Figshare
Year: 2015
Subjects: subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Marine Biology
subject: Computational Biology

description: Blood pressure data in relation to the optimal mean arterial blood pressure or gestational age, regional cerebral oxygen saturation, and neurodevelopmental disability. (DOCX 19Â kb)