cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Knowledge Acquisition from Social Platforms Based on Network Distributions Fitting
Creators: name: Jankowski, Jarosław
name: Michalski, Radosław
name: Bródka, Piotr
name: Kazienko, Przemysław
name: Utz, Sonja
Publisher: name: arXiv
Year: 2015
Subjects: subject: Social and Information Networks (cs.SI)
subject: FOS: Computer and information sciences

description: The uniqueness of online social networks makes it possible to implement new methods that increase the quality and effectiveness of research processes. While surveys are one of the most important tools for research, the representativeness of selected online samples is often a challenge and the results are hardly generalizable. An approach based on surveys with representativeness targeted at network measure distributions is proposed and analysed in this paper. Its main goal is to focus not only on sample representativeness in terms of demographic attributes, but also to follow the measures distributions within main network. The approach presented has many application areas related to online research, sampling a network for the evaluation of collaborative learning processes, and candidate selection for training purposes with the ability to distribute information within a social network.
Fractional Weierstrass function by application of Jumarie fractional trigonometric functions and its analysis
Creators: name: Ghosh, Uttam
name: Sarkar, Susmita
name: Das, Shantanu
Publisher: name: arXiv
Year: 2015
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics

description: The classical example of no-where differentiable but everywhere continuous function is Weierstrass function. In this paper we define the fractional order Weierstrass function in terms of Jumarie fractional trigonometric functions. The Holder exponent and Box dimension of this function are calculated here. It is established that the Holder exponent and Box dimension of this fractional order Weierstrass function are the same as in the original Weierstrass function, independent of incorporating the fractional trigonometric function. This is new development in generalizing the classical Weierstrass function by usage of fractional trigonometric function and obtain its character and also of fractional derivative of fractional Weierstrass function by Jumarie fractional derivative, and establishing that roughness index are invariant to this generalization.
description: 17 pages, 2 figures, submitted to Physics Letters A
Paper spray mass spectrometry for high-throughput quantification of nicotine and cotinine
Creators: name: Glish, G.L.
name: Minges, J.T.
name: Randell, S.H.
name: Keating, J.E.
Publisher: name: Royal Society of Chemistry
Year: 2018

description: The rapid release of new tobacco products requires high-throughput quantitative methods to support tobacco research. Sample preparation for LC-MS and GC-MS is time consuming and limits throughput. Paper spray tandem mass spectrometry (PS-MS/MS) is proposed and validated as a simple and rapid method for quantification of nicotine and cotinine in complex matrices to support tobacco-related research. Air liquid interface (ALI) human tracheobronchial epithelial cell (HTBEC) cultures were exposed to tobacco smoke using a Vitrocell VC-10 smoking machine. Apical culture washes (phosphate buffered saline, PBS) and basolateral media were analyzed with the PS-MS/MS method. GC-MS/MS was used as a comparative quantitative technique. The PS-MS/MS approach allowed for direct spotting of samples on the paper substrate, whereas the GC-MS/MS method required additional sample preparation in the form of solvent-solvent extraction. Limits of quantitation (LOQs) were higher with the PS-MS/MS approach than GC-MS/MS, but still below the relevant concentrations found in HTBEC smoke exposure experiments as well as most clinical applications. PS-MS/MS is readily achieved on mass spectrometers that include atmospheric pressure inlets, and allows for convenient quantification from complex matrices that would otherwise require additional sample preparation and chromatographic separation. © 2017 The Royal Society of Chemistry.
Factor XIIIA-expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking
Creators: name: Godfrey, V.
name: Hayes, D.N.
name: Baldwin, A.S.
name: Hayward, M.C.
name: Kattula, S.
name: Wolberg, A.S.
name: Gorentla, B.K.
name: Oderup, C.
name: Ghosh, S.K.
name: Leslie, P.L.
name: Randell, S.H.
name: Porrello, A.
name: Wilkerson, M.D.
name: Pecot, C.V.
name: Azam, S.H.
name: Holtzhausen, A.
name: Harrison, E.B.
name: Makowski, L.
name: Chao, Y.L.
name: Weiss, J.
name: Earp, H.S.
name: Bae, S.
name: Waugh, T.A.
Publisher: name: Nature Publishing Group
Year: 2018

description: Lung cancer is the leading cause of cancer-related deaths worldwide, and lung squamous carcinomas (LUSC) represent about 30% of cases. Molecular aberrations in lung adenocarcinomas have allowed for effective targeted treatments, but corresponding therapeutic advances in LUSC have not materialized. However, immune checkpoint inhibitors in sub-populations of LUSC patients have led to exciting responses. Using computational analyses of The Cancer Genome Atlas, we identified a subset of LUSC tumors characterized by dense infiltration of inflammatory monocytes (IMs) and poor survival. With novel, immunocompetent metastasis models, we demonstrated that tumor cell derived CCL2-mediated recruitment of IMs is necessary and sufficient for LUSC metastasis. Pharmacologic inhibition of IM recruitment had substantial anti-metastatic effects. Notably, we show that IMs highly express Factor XIIIA, which promotes fibrin cross-linking to create a scaffold for LUSC cell invasion and metastases. Consistently, human LUSC samples containing extensive cross-linked fibrin in the microenvironment correlated with poor survival.
(101831) Georgina Caroline Annie Taylor
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Photoproduction of $a_0(980)$ and $f_0(980)$
Creators: name: Donnachie, A.
name: Kalashnikova, Yu S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: There is no generally accepted view of the structure of the light-quark non-strange scalar mesons. A variety of models have been proposed that encompass $qq\bar{q}\bar{q}$, molecular, $q\bar{q}$ and glueball states in various combinations. Previously we considered scalar-meson photoproduction in a simple Regge-pole model and showed that it was experimentally viable. Recent data on the photoproduction of $a_0(980)$ and $f_0(980)$ confirm this. We extend our model to incorporate Regge cuts, based on our knowledge of $π^0$ photoproduction. The theoretical predictions are compared to the $a_0(980)$ and $f_0(980)$ photoproduction data.
description: Minor rewording, inclusion of NS predictions in addition to KL predictions, figures 3 and 4 modified accordingly
{23}Na nuclear spin-lattice relaxation studies of Na2Ni2TeO6
Creators: name: Itoh, Y.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We report on {23}Na NMR studies of a honeycomb lattice antiferromagnet Na2Ni2TeO6 by {23}Na nuclear spin-echo techniques. The {23}Na nuclear spin-lattice relaxation rate 1/{23}T_1 exhibits critical divergence near a Neel temperature T_N = 26 K, a narrow critical region, and a critical exponent w = 0.34 in 1/{23}T_1 = a (T/T_N - 1)^{-w} for Na2Ni2TeO6, and T_N = 18 K for Na2(Ni{0.5}Cu{0.5})2TeO6. Although the uniform magnetic susceptibility of Na2Ni2TeO6 exhibits a broad maximum at 35 K characteristic of low dimensional spin systems, the NMR results indicate three dimensional critical phenomenon around the Neel temperature.
description: 4 pages, 6 figures
Transient particle energies in shortcuts to adiabatic expansions of harmonic traps
Creators: name: Cui, Yang-Yang
name: Chen, Xi
name: Muga, J. G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The expansion of a harmonic potential that holds a quantum particle may be realized without any final particle excitation but much faster than adiabatically via "shortcuts to adiabaticity" (STA). While ideally the process time can be reduced to zero, practical limitations and constraints impose minimal finite times for the externally controlled time-dependent frequency protocols. We examine the role of different time-averaged energies (total, kinetic, potential, non-adiabatic) and of the instantaneous power in characterizing or selecting different protocols.Specifically, we prove a virial theorem for STA processes, set minimal energies for specific times or viceversa, and discuss their realizability by means of Dirac impulses or otherwise.
description: 8 pages, 4 figures
CBS News Poll: Halloween/Horror Movies/Comic Books
Creators: name: CBS News
Publisher: name: Roper Center for Public Opinion Research
Year: 2019

description: Internet hackers (1); Veterans Administration (1); visit an art museum (1); fine art pricing (1); personally own a musical instrument (1); read comic books (1); daylight savings time (1); get by without electricity (1); love letters (1); trick-or-treating at Halloween (1); scariest horror film character (1); religious affiliation (1); personal finances (1); political party preference (1).
Beware Cold Agglutinins in Organ Donors! Ex Vivo Lung Perfusion From an Uncontrolled Donation After Circulatory-Determination-of-Death Donor With a Cold Agglutinin: A Case Report
Creators: name: Funkhouser, W.K.
name: Blackwell, J.W.
name: Birchard, K.R.
name: Simmons, W.T.
name: Randell, S.H.
name: Beamer, S.E.
name: Egan, T.M.
name: Venkataraman, A.
Publisher: name: Elsevier USA
Year: 2017

description: Background We began to recover lungs from uncontrolled donation after circulatory determination of death to assess for transplant suitability by means of ex vivo lung perfusion (EVLP) and computerized tomographic (CT) scan. Our first case had a cold agglutinin with an interesting outcome. Case report A 60-year-old man collapsed at home and was pronounced dead by Emergency Medical Services personnel. Next-of-kin consented to lung retrieval, and the decedent was ventilated and transported. Lungs were flushed with cold Perfadex, removed, and stored cold. The lungs did not flush well. Medical history revealed a recent hemolytic anemia and a known cold agglutinin. Warm nonventilated ischemia time was 51 minutes. O2-ventilated ischemia time was 141 minutes. Total cold ischemia time was 6.5 hours. At cannulation for EVLP, established clots were retrieved from both pulmonary arteries. At initiation of EVLP with Steen solution, tiny red aggregates were observed initially. With warming, the aggregates disappeared and the perfusate became red. After 1 hour, EVLP was stopped because of florid pulmonary edema. The lungs were cooled to 20°C; tiny red aggregates formed again in the perfusate. Ex vivo CT scan showed areas of pulmonary edema and a pyramidal right middle lobe opacity. Dissection showed multiple pulmonary emboli—the likely cause of death. However, histology showed agglutinated red blood cells in the microvasculature in pre- and post-EVLP biopsies, which may have contributed to inadequate parenchymal preservation. Conclusions Organ donors with cold agglutinins may not be suitable owing to the impact of hypothermic preservation.
(101833) Henry Augustus Ward Taylor
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Quantification and localization of ischaemic lesions on computed tomography myocardial perfusion imaging visualized using different color scales
Creators: name: Zabala-Travers, Silvina
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Cardiac
subject: CT-Quantitative
subject: CT
subject: Perception image
subject: Observer performance
subject: Localisation
subject: Quality assurance

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Despite the increased use of color for the interpretation of medical images, no visualization guidelines are currently available. Moreover, the effect of color on the interpretation of medical images has not been addressed. Laboratory studies report...
Constraints on just enough inflation preceded by a thermal era
Creators: name: Das, Suratna
name: Goswami, Gaurav
name: Prasad, Jayanti
name: Rangarajan, Raghavan
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: If the inflationary era is preceded by a radiation dominated era in which the inflaton too was in thermal equilibrium at some very early time then the CMB data places an upper bound on the comoving temperature of the (decoupled) inflaton quanta. In addition, if one considers models of "just enough" inflation, where the number of e-foldings of inflation is just enough to solve the horizon and flatness problems, then we get a lower bound on the Hubble parameter during inflation, $H_{\rm inf}$, which is in severe conflict with the upper bound from tensor perturbations. Alternatively, imposing the upper bound on $H_{\rm inf}$ implies that such scenarios are compatible with the data only if the number of relativistic degrees of freedom in the thermal bath in the pre-inflationary Universe is extremely large (greater than $10^9$ or $10^{11})$. We are not aware of scenarios in which this can be satisfied.
description: Clearer presentation, agrees with published version
A slippery cause of a slimy problem: Mucin induction by an esterified lipid
Creators: name: Zeldin, D.C.
name: Randell, S.H.
Publisher: name: American Thoracic Society
Year: 2017

description: Secreted gel-forming mucins (1) are key components of mucociliary transport, a vital airway innate defense mechanism (2). Mucin and mucus alterations are present in asthma (3), cystic fibrosis (4), and chronic bronchitis (5), and mucin gene polymorphisms are also implicated in the pathogenesis of idiopathic pulmonary fibrosis (6). Increased numbers of mucin-producing goblet cells at locations where they are normally present (hyperplasia) or absent (metaplasia) are pathognomonic responses of the airways to diverse environmental stimuli. Although they are clearly important and protective at homeostatic levels, mucin and mucus are likely harmful when produced in excess, as most vividly and tragically illustrated in fatal asthma (Figure 1). Importantly, specific therapies targeting mucin hypersecretion in asthma and other lung pathologies are not currently available.
(101834) Isabel Charlotte Taylor
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(101829) Charlotte Anne Joll Goodenough
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Pharmacological rescue of conditionally reprogrammed cystic fibrosis bronchial epithelial cells
Creators: name: Liu, X.
name: Schlegel, R.
name: Boyles, S.E.
name: Gentzsch, M.
name: Chaudhry, I.G.
name: Dang, H.
name: Randell, S.H.
name: Quinney, N.L.
name: Cho, C.
name: Cheluvaraju, C.
Publisher: name: American Thoracic Society
Year: 2017

description: Well-differentiated primary human bronchial epithelial (HBE) cell cultures are vital for cystic fibrosis (CF) research, particularly for the development of cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs. Culturing of epithelial cells with irradiated 3T3 fibroblast feeder cells plus the RhoA kinase inhibitor Y-27632 (Y), termed conditionally reprogrammed cell (CRC) technology, enhances cell growth and lifespan while preserving cell-of-origin functionality. We initially determined the electrophysiological and morphological characteristics of conventional versus CRC-expanded non-CF HBE cells. On the basis of these findings, we then created six CF cell CRC populations, three from sequentially obtained CF lungs and three from F508 del homozygous donors previously obtained and cryopreserved using conventional culture methods. Growth curves were plotted, and cells were subcultured, without irradiated feeders plus Y, into air-liquid interface conditions in nonproprietary and proprietary Ultroser G-containing media and were allowed to differentiate. Ussing chamber studies were performed after treatment of F508 del homozygous CF cells with the CFTR modulator VX-809. Bronchial epithelial cells grew exponentially in feeders plus Y, dramatically surpassing the numbers of conventionally grown cells. Passage 5 and 10 CRC HBE cells formed confluent mucociliary air-liquid interface cultures. There were differences in cell morphology and current magnitude as a function of extended passage, but the effect of VX-809 in increasing CFTR function was significant in CRC-expanded F508 del HBE cells. Thus, CRC technology expands the supply of functional primary CF HBE cells for testing CFTR modulators in Ussing chambers.
Additional file 2 of Use and perception of risk: traditional medicines of Pakistani immigrants in Norway
Creators: name: Khalid, Saliha
name: Kristoffersen, Agnete Egilsdatter
name: Alpers, Lise-Merete
name: Borge, Christine Råheim
name: Qureshi, Samera Azeem
name: Stub, Trine
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biological Sciences not elsewhere classified
Science Policy
Mental Health

description: Supplementary Material 2
Contents Literaturverwaltung Kurzanleitungen
Creators: name: Hehl, Hans
Publisher: name: Zenodo
Year: 2022
Subjects: Literaturverwaltung, Zeitschriftentitel, Aufsatznachweise, sachliche Erschliessung

description: Diese Literaturverwaltung ist eine Besonderheit, insofern sie mit den einfachsten Mitteln auch von einem Nichtfachmann entwickelt und aufgebaut werden kann. Ausreichende Kenntnisse in HTML und JavaScript und ein gewöhnliches Notebook genügen. Zwei umfangreiche, eng miteinander verbundene Datenbanken, eine Liste mit ca. 90000 Zeitschriftentiteln, ergänzt durch thematische und Standortdaten, und ca. 100000 Aufsatznachweise, übernommen aus relevanten Fachdatenbanken, bilden die Datenbasis.
 Deponiert sind diese Daten ausschliesslich in Webformularen, wofür bisher keine Beispiele bekannt sind.
การพัฒนาแอปพลิเคชันสำหรับการเลือกใช้สถิติในงานวิจัย
Creators: name: สุดา เธียรมนตรี
Publisher: name: มหาวิทยาลัยแม่โจ้
Year: 2018
Subjects: แอปพลิเคชันช่วยเลือกสถิติสำหรับงานวิจัย
สถิติทดสอบ
ระบบกฎ

description: วารสารแม่โจ้เทคโนโลยีสารสนเทศและนวัตกรรม, 4, 2, 22 ถึง 33
title: Intracranial Solitary Fibrous Tumors: Imaging Features and Differential Diagnosis
Creators: name: Soliman, Radwa
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Neoplasia
subject: Screening
subject: MR
subject: CNS

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The purpose of our educational exhibit is to get an overview of intracranial Solitary Fibrous Tumors (SFTs), clinical significance, pathological features and management plan. Discuss the imaging features of SFTs and get an approach for the...
title: Imaging of malignant renal tumors in children: A pictorial essay
Creators: name: Gulseren, Yildiz
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Tissue characterisation
subject: Cancer
subject: Imaging sequences
subject: Ultrasound
subject: MR
subject: CT
subject: Paediatric
subject: Kidney
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The correct diagnosis of renal tumors may be coercive so a thorough understanding of the distinctive imaging features is helpful to analyze and describe lesions. We aimed to review the radiologic findings of pediatric renal tumors and evaluate the...
การพัฒนาแอปพลิเคชันเพื่อการเรียนรู้บนสมาร์ทโฟน เรื่อง สัตว์มีกระดูกสันหลัง สำหรับนักเรียนชั้นมัธยมศึกษาปีที่ 3 โรงเรียนวรดิตถ์วิทยาประสูทน์
Creators: name: สุเมธ ปัจฉิมสุภาคม
Publisher: name: มหาวิทยาลัยแม่โจ้
Year: 2018
Subjects: แอปพลิเคชันเพื่อการเรียนรู้
สมาร์ทโฟน
สัตว์มีกระดูกสันหลัง

description: วารสารแม่โจ้เทคโนโลยีสารสนเทศและนวัตกรรม, 4, 2, 46 ถึง 57
Generation of longitudinal electric current by the transversal electromagnetic field in collisional plasma
Creators: name: Latyshev, A. V.
name: Yushkanov, A. A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences
subject: 81V10, 81V99, 82B40

description: Kinetic Vlasov equation for collisional plasmas with BGK (Bhatnagar-Gross-Krook) collision integral is used. The case of arbitrary temperature (i.e. arbitrary degree of degeneration of electronic gas) is considered. From kinetic Vlasov equation the distribution function in square-law approximation on size of transversal electromagnetic field is received. The formula for calculation electric current is deduced. This formula contains one-dimension quadrature. It is shown, that the nonlinearity account leads to occurrence the longitudinal electric current directed along the wave vector. This longitudinal current is perpendicular to the known transversal classical current, received at the linear analysis. When frequency of collisions tends to zero, all received results for collisional plasma pass in known corresponding formulas for collisionless plasma. The case of small values of wave number is considered. It is shown, that the received quantity of longitudinal current at tendency of frequency of collisions to zero also passes in known corresponding expression of current for collisionless plasmas. Graphic research of dimensionless density of the current depending on wave number, frequency of oscillations of electromagnetic field and frequency of electron collisions with plasma particles is carried out.
description: 22 pages, 6 figures
การพัฒนาโมบายแอปพลิเคชันสำหรับร้านอาหารจานด่วน
Creators: name: สุดา เธียรมนตรี
Publisher: name: มหาวิทยาลัยแม่โจ้
Year: 2018
Subjects: โมบายแอปพลิเคชัน
การตรวจสอบปริมาณวัตถุดิบ
ร้านอาหารจานด่วน

description: วารสารแม่โจ้เทคโนโลยีสารสนเทศและนวัตกรรม, 4, 2, 11 ถึง 21
Conditional reprogramming and long-term expansion of normal and tumor cells from human biospecimens
Creators: name: Yuan, H.
name: Kallakury, B.
name: Sripadhan, P.
name: Albanese, C.
name: Choudhury, S.
name: Dakic, A.
name: Agarwal, S.
name: Chen, C.
name: Suprynowicz, F.A.
name: Darling, T.
name: Dritschilo, A.
name: Thangapazham, R.
name: Zheng, Y.-L.
name: Hou, T.-W.
name: Timofeeva, O.
name: Lu, J.
name: Randell, S.H.
name: Liu, X.
name: Schlegel, R.
name: Krawczyk, E.
name: Simic, V.
name: Palechor-Ceron, N.
name: Tang, D.
Publisher: name: Nature Publishing Group
Year: 2017

description: Historically, it has been difficult to propagate cells in vitro that are derived directly from human tumors or healthy tissue. However, in vitro preclinical models are essential tools for both the study of basic cancer biology and the promotion of translational research, including drug discovery and drug target identification. This protocol describes conditional reprogramming (CR), which involves coculture of irradiated mouse fibroblast feeder cells with normal and tumor human epithelial cells in the presence of a Rho kinase inhibitor (Y-27632). CR cells can be used for various applications, including regenerative medicine, drug sensitivity testing, gene expression profiling and xenograft studies. The method requires a pathologist to differentiate healthy tissue from tumor tissue, and basic tissue culture skills. The protocol can be used with cells derived from both fresh and cryopreserved tissue samples. As approximately 1 million cells can be generated in 7 d, the technique is directly applicable to diagnostic and predictive medicine. Moreover, the epithelial cells can be propagated indefinitely in vitro, yet retain the capacity to become fully differentiated when placed into conditions that mimic their natural environment.
Simulating thermal boundary conditions of spin-lattice models with weighted averages
Creators: name: Wang, Wenlong
Publisher: name: arXiv
Year: 2015
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Thermal boundary conditions has played an increasingly important role in revealing the nature of short-range spin glasses and is likely to be relevant also for other disordered systems. Diffusion method initializing each replica with a random boundary condition at the infinite temperature using population annealing has been used in recent large-scale simulations. However, the efficiency of this method can be greatly suppressed because of temperature chaos. For example, most samples have some boundary conditions that are completely eliminated from the population in the process of annealing at low temperatures. In this work, I study a weighted average method to solve this problem by simulating each boundary conditions separately and collect data using weighted averages. The efficiency of the two methods are studied using both population annealing and parallel tempering, showing that the weighted average method is more efficient and accurate.
description: 7 pages, 8 figures
The dual phosphodiesterase 3 and 4 inhibitor RPL554 stimulates CFTR and ciliary beating in primary cultures of bronchial epithelia
Creators: name: Matthes, E.
name: Billet, A.
name: Ferguson, A.J.
name: Hanrahan, J.W.
name: Abbott-Banner, K.
name: Turner, M.J.
name: Thomas, D.Y.
name: Ostrowski, L.E.
name: Randell, S.H.
Publisher: name: American Physiological Society
Year: 2016

description: Cystic fibrosis (CF), a genetic disease caused by mutations in the CFTR gene, is a life-limiting disease characterized by chronic bacterial airway infection and severe inflammation. Some CFTR mutants have reduced responsiveness to cAMP/PKA signaling; hence, pharmacological agents that elevate intracellular cAMP are potentially useful for the treatment of CF. By inhibiting cAMP breakdown, phosphodiesterase (PDE) inhibitors stimulate CFTR in vitro and in vivo. Here, we demonstrate that PDE inhibition by RPL554, a drug that has been shown to cause bronchodilation in asthma and chronic obstructive pulmonary disease (COPD) patients, stimulates CFTR-dependent ion secretion across bronchial epithelial cells isolated from patients carrying the R117H/F508del CF genotype. RPL554-induced CFTR activity was further increased by the potentiator VX-770, suggesting an additional benefit by the drug combination. RPL554 also increased cilia beat frequency in primary human bronchial epithelial cells. The results indicate RPL554 may increase mucociliary clearance through stimulation of CFTR and increasing ciliary beat frequency and thus could provide a novel therapeutic option for CF.
Stability conditions for one-dimensional optical solitons in cubic-quintic-septimal media
Creators: name: Reyna, Albert S.
name: Malomed, Boris A.
name: de Araujo, Cid B.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: Pattern Formation and Solitons (nlin.PS)
subject: FOS: Physical sciences

description: Conditions for stable propagation of one-dimensional bright spatial solitons in media exhibiting optical nonlinearities up to the seventh-order are investigated. The results show well-defined stability regions even when all the nonlinear terms are focusing. Conditions for onset of the supercritical collapse of the optical beam are identified too. A variational approximation is used to predict dependence of the soliton propagation constant on the norm, and respective stability regions are identified using the Vakhitov-Kolokolov criterion. Analytical results obtained by means of the variational approximation are corroborated by numerical simulations of the cubic-quintic-septimal nonlinear Schroedinger equation.
description: Physical Review A, in press
An Official American Thoracic Society Workshop Report 2015. Stem Cells and Cell Therapies in Lung Biology and Diseases
Creators: name: ATS Subcommittee on Stem Cells and Cell Therapies
name: Waddell, T.
name: Thébaud, B.
name: Weiss, D.J.
name: Wagner, D.E.
name: Majka, S.
name: Randell, S.H.
name: Ott, H.
name: Cardoso, W.V.
name: Gilpin, S.E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The University of Vermont College of Medicine, in collaboration with the NHLBI, Alpha-1 Foundation, American Thoracic Society, Cystic Fibrosis Foundation, European Respiratory Society, International Society for Cellular Therapy, and the Pulmonary Fibrosis Foundation, convened a workshop, "Stem Cells and Cell Therapies in Lung Biology and Lung Diseases," held July 27 to 30, 2015, at the University of Vermont. The conference objectives were to review the current understanding of the role of stem and progenitor cells in lung repair after injury and to review the current status of cell therapy and ex vivo bioengineering approaches for lung diseases. These are all rapidly expanding areas of study that both provide further insight into and challenge traditional views of mechanisms of lung repair after injury and pathogenesis of several lung diseases. The goals of the conference were to summarize the current state of the field, discuss and debate current controversies, and identify future research directions and opportunities for both basic and translational research in cell-based therapies for lung diseases. This 10th anniversary conference was a follow up to five previous biennial conferences held at the University of Vermont in 2005, 2007, 2009, 2011, and 2013. Each of those conferences, also sponsored by the National Institutes of Health, American Thoracic Society, and respiratory disease foundations, has been important in helping guide research and funding priorities. The major conference recommendations are summarized at the end of the report and highlight both the significant progress and major challenges in these rapidly progressing fields.
(101827) Ellen Payne
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: MRI pattern of hepatic metastases from uveal melanoma: can it be correlated with patients' prognosis?
Creators: name: Zawaideh, Jeries
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Metastases
subject: Imaging sequences
subject: MR-Diffusion/Perfusion
subject: MR
subject: Oncology
subject: Liver
subject: Abdomen

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Uveal melanoma is a rare pathology with an estimated incidence of 7 cases per million per year, from a minimum of 2 per million in registries of Spain and southern Italy up to 8 per million in Norway and Denmark [1]. Uveal melanoma has often a poor...
(101828) Thomas David Taylor
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Mutations in RSPH1 cause primary ciliary dyskinesia with a unique clinical and ciliary phenotype
Creators: name: Nickerson, D.A.
name: Zariwala, M.A.
name: Olson, C.A.
name: Yin, W.
name: Ostrowski, L.E.
name: Kohl, S.
name: Gee, H.Y.
name: Sagel, S.D.
name: Olivier, K.N.
name: Carson, J.L.
name: Milla, C.E.
name: Hazucha, M.J.
name: Dang, H.
name: Otto, E.A.
name: Sannuti, A.
name: Bamshad, M.J.
name: Wolf, W.E.
name: Noone, P.G.
name: Krischer, J.
name: Metjian, H.M.
name: Patrone, M.V.
name: Leigh, M.W.
name: Sears, P.R.
name: Shendure, J.
name: Dell, S.D.
name: Randell, S.H.
name: Hurd, T.W.
name: Lee, H.-S.
name: Rosenfeld, M.
name: Davis, S.D.
name: Hildebrandt, F.
name: Kircher, M.
name: Ferkol, T.W.
name: Noone, P.J.
name: Knowles, M.R.
name: Halbritter, J.
Publisher: name: American Thoracic Society
Year: 2014

description: Rationale: Primary ciliary dyskinesia (PCD) is a genetically heterogeneous recessive disorder of motile cilia, but the genetic cause is not defined for all patients with PCD. Objectives: To identify disease-causingmutations in novel genes, we performed exome sequencing, follow-up characterization, mutation scanning, and genotype-phenotype studies in patients with PCD. Methods: Whole-exome sequencing was performed using NimbleGen capture and Illumina HiSeq sequencing. Sanger-based sequencing was used for mutation scanning, validation, and segregation analysis. Measurements and Main Results: We performed exome sequencing on an affected sib-pair with normal ultrastructure in more than 85% of cilia. A homozygous splice-site mutation was detected in RSPH1 in both siblings; parents were carriers. Screening RSPH1 in 413 unrelated probands, including 325 with PCD and 88 with idiopathic bronchiectasis, revealed biallelic loss-of-function mutations in nine additional probands. Five affected siblings of probands in RSPH1 families harbored the familial mutations. The 16 individuals with RSPH1 mutations had some features of PCD; however, nasal nitric oxide levels were higher than in patients with PCD with other gene mutations (98.3 vs. 20.7 nl/min; P , 0.0003). Additionally, individuals with RSPH1 mutations had a lower prevalence (8 of 16) of neonatal respiratory distress, and later onset of daily wet cough than typical for PCD, and better lung function (FEV1), compared with 75 age- and sex-matched PCD cases (73.0 vs. 61.8, FEV1 % predicted; P = 0.043). Cilia from individuals with RSPH1 mutations had normal beat frequency (6.16Hz at 258C), but an abnormal, circular beat pattern. Conclusions: The milder clinical disease and higher nasal nitric oxide in individuals with biallelic mutations in RSPH1 provides evidence of a unique genotype-phenotype relationship in PCD, and suggests that mutations in RSPH1 may be associated with residual ciliary function.
Emission line selected galaxies at $z=0.6-2$ in GOODS South: Stellar masses, SFRs, and large scale structure
Creators: name: Kochiashvili, I.
name: Møller, P.
name: Milvang-Jensen, B.
name: Christensen, L.
name: Fynbo, J. P. U.
name: Freudling, W.
name: Clément, B.
name: Cuby, J. -G.
name: Zabl, J.
name: Zibetti, S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We have obtained deep NIR narrow and broad (J and Y) band imaging data of the GOODS-South field. The narrow band filter is centered at 1060 nm corresponding to redshifts $z = 0.62, 1.15, 1.85$ for the strong emission lines H$α$, $[$OIII$]$/H$β$ and $[$OII$]$, respectively. From those data we extract a well defined sample ($M(AB)=24.8$ in the narrow band) of objects with large emission line equivalent widths in the narrow band. Via SED fits to published broad band data we identify which of the three lines we have detected and assign redshifts accordingly. This results in a well defined, strong emission line selected sample of galaxies down to lower masses than can easily be obtained with only continuum flux limited selection techniques. We compare the (SED fitting-derived) main sequence of star-formation (MS) of our sample to previous works and find that it has a steeper slope than that of samples of more massive galaxies. We conclude that the MS steepens at lower (below $M_{\star} = 10^{9.4} M_{\odot}$) galaxy masses. We also show that the SFR at any redshift is higher in our sample. We attribute this to the targeted selection of galaxies with large emission line equivalent widths, and conclude that our sample presumably forms the upper boundary of the MS. We briefly investigate and outline how samples with accurate redshifts down to those low stellar masses open a new window to study the formation of large scale structure in the early universe. In particular we report on the detection of a young galaxy cluster at $z=1.85$ which features a central massive galaxy which is the candidate of an early stage cD galaxy, and we identify a likely filament mapped out by $[$OIII$]$ and $Hβ$ emitting galaxies at $z=1.15$.
description: 18 pages, 19 figures, version accepted for publication in A&A
Case Study Research Defined [White paper]
Creators: name: Coombs, H. V.
Publisher: name: Zenodo
Year: 2022
Subjects: Case Study
Qualitative Research
Single Case Study
Multiple Case Study
White Paper

description: A case study is a methodological research approach used to generate an in-depth understanding of a contemporary issue or phenomenon in a bounded system. A case study is one of the most widely used and accepted means of qualitative research methods in the social sciences. The case study approach is particularly useful to employ when there is a need to obtain an in-depth appreciation of an issue, event or phenomenon of interest, in its natural real-life context . Case studies provide researchers with an opportunity for greater depth of understanding of an issue. The case study design is preferred as a research strategy when “how,” “why,” and “what” questions are the interest of the researcher.
description: {"references": ["Bloomberg, L. D., & Volpe, M. (2022). Completing your qualitative dissertation: A road map from beginning to end. SAGE.", "Coombs, H. (2022). Case study research: single or multiple [White paper]. Southern Utah University. https://haydencoombs.files.wordpress.com/2022/09/case-study-research-coombs-2022-3.pdf", "Creswell, J. W., & Poth, C. N. (2018). Qualitative inquiry and research design: Choosing among five approaches. SAGE.", "Crowe, S., Cresswell, K., Robertson, A., Huby, G., Avery, A., & Sheikh, A. (2011). The case study approach. BMC medical research methodology, 11, 100. https://doi.org/10.1186/1471-2288-11-100.", "Stake, R. E. (2010). The art of case study research. SAGE.", "Yin, R. K. (2018). Case Study Research and Applications: Designs and Methods (6th ed.). SAGE."]}
Evidence for multiple roles for grainyheadlike 2 in the establishment and maintenance of human mucociliary airway epithelium
Creators: name: Vockley, C.M.
name: Gao, X.
name: Reddy, T.E.
name: Xue, Y.
name: Newberry, K.M.
name: Randell, S.H.
name: Hogan, B.L.M.
name: Pauli, F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Most of the airways of the human lung are lined by an epithelium made up of ciliated and secretory luminal cells and undifferentiated basal progenitor cells. The integrity of this epithelium and its ability to act as a selective barrier are critical for normal lung function. In other epithelia, there is evidence that transcription factors of the evolutionarily conserved grainyheadlike (GRHL) family play key roles in coordinating multiple cellular processes required for epithelial morphogenesis, differentiation, remodeling, and repair. However, only a few target genes have been identified, and little is known about GRHL function in the adult lung. Here we focus on the role of GRHL2 in primary human bronchial epithelial cells, both as undifferentiated progenitors and as they differentiate in air-liquid interface culture into an organized mucociliary epithelium with transepithelial resistance. Using a dominant-negative protein or shRNA to inhibit GRHL2, we follow changes in epithelial phenotype and gene transcription using RNA sequencing or microarray analysis. We identify several hundreds of genes that are directly or indirectly regulated by GRHL2 in both undifferentiated cells and air-liquid interface cultures. Using ChIP sequencing to map sites of GRHL2 binding in the basal cells, we identify 7,687 potential primary targets and confirm that GRHL2 binding is strongly enriched near GRHL2-regulated genes. Taken together, the results support the hypothesis that GRHL2 plays a key role in regulating many physiological functions of human airway epithelium, including those involving cell morphogenesis, adhesion, and motility.
title: Imaging findings of uveal melanoma metastases.
Creators: name: Zawaideh, Jeries
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Metastases
subject: Imaging sequences
subject: MR-Diffusion/Perfusion
subject: MR
subject: Oncology
subject: Liver
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The aim of the present poster is to illustrate the imaging aspects of metastases seen with different imaging techniques used for the evaluation of patients with a history of uveal melanoma. We reviewed in the context of uveal melanoma different...
การพัฒนาบทเรียนคอมพิวเตอร์มัลติมีเดีย เรื่อง อุปกรณ์คอมพิวเตอร์ ระดับชั้นประถมศึกษาปีที่ 2: กรณีศึกษาโรงเรียนประตูชัย จังหวัดพระนครศรีอยุธยา
Creators: name: สรียา ศิลาบุตร
Publisher: name: มหาวิทยาลัยแม่โจ้
Year: 2018
Subjects: บทเรียนคอมพิวเตอร์มัลติมีเดีย
อุปกรณ์คอมพิวเตอร์
ระดับชั้นประถมศึกษา

description: วารสารแม่โจ้เทคโนโลยีสารสนเทศและนวัตกรรม, 4, 2, 69 ถึง 80
title: Urinary system under pressure: A pictorial essay of CT Urography findings.
Creators: name: Mellou, Vasiliki
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Urinary Tract / Bladder
subject: Kidney
subject: Vascular
subject: CT
subject: Diagnostic procedure
subject: Contrast agent-other
subject: Imaging sequences
subject: Dilatation
subject: Calcifications / Calculi
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To demonstrate the imaging spectrum of compression disorders of the urinary tract and its accompanying vascular structures, such as the renal vein and its branches, on CT Urography...
β-Catenin-SOX2 signaling regulates the fate of developing airway epithelium
Creators: name: Snyder, J.C.
name: Brockway, B.L.
name: Chen, H.
name: Drake, J.A.
name: Randell, S.H.
name: Que, J.
name: Hashimoto, S.
name: Stripp, B.R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Wnt-β-catenin signaling regulates cell fate during organ development and postnatal tissue maintenance, but its contribution to specification of distinct lung epithelial lineages is still unclear. To address this question, we used a Cre recombinase (Cre)-LoxP approach to activate canonical Wnt signaling ectopically in developing lung endoderm. We found that persistent activation of canonical Wnt signaling within distal lung endoderm was permissive for normal development of alveolar epithelium, yet led to the loss of developing bronchiolar epithelium and ectasis of distal conducting airways. Activation of canonical Wnt led to ectopic expression of a lymphoid-enhancing factor and a T-cell factor (LEF and TCF, respectively) and absence of SRY (sex-determining region Y)-box 2 (SOX2) and tumor protein p63 (p63) expression in proximal derivatives. Conditional loss of SOX2 in airways phenocopied epithelial differentiation defects observed with ectopic activation of canonical Wnt. Our data suggest that Wnt negatively regulates a SOX2-dependent signaling program required for developmental progression of the bronchiolar lineage.
title: Ingestion of foreign bodies and possible intra-abdominal complications: CT Findings.
Creators: name: Brunie, Francois Xavier
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Obstruction / Occlusion
subject: Foreign bodies
subject: Abscess
subject: Computer Applications-Detection, diagnosis
subject: Complications
subject: CT
subject: Liver
subject: Gastrointestinal tract
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Review the radiological findings that can be observed in the abdomen after ingestion of foreign bodies. Distinguish the main complications secondary to ingestion of foreign...