cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
In Vitro Phosphorylation of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase by Src Kinase
Creators: name: Schaller, Michael D.
name: Cable, Jennifer
name: Campbell, Sharon L.
name: Prutzman, Kirk
name: Chen, Xian
name: Gunawardena, Harsha P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Focal adhesion kinase (FAK), a key regulator of cell adhesion and migration, is overexpressed in many types of cancer. The C-terminal focal adhesion targeting (FAT) domain of FAK is necessary for proper localization of FAK to focal adhesions and subsequent activation. Phosphorylation of Y926 in the FAT domain by the tyrosine kinase Src has been shown to promote metastasis and invasion in vivo by linking the FAT domain to the MAPK pathway via its interaction with Grb2. Several groups have reported that inherent conformational dynamics in the FAT domain likely regulate phosphorylation of Y926; however, what regulates these dynamics is unknown. In this paper, we demonstrate that there are two sites of in vitro Src-mediated phosphorylation in the FAT domain: Y926, which has been shown to affect FAK function in vivo, and Y1008, which has no known biological role. The phosphorylation of these two tyrosine residues is pH dependent, but this does not reflect the pH dependence of Src kinase activity. CD and NMR data indicate that the stability and conformational dynamics of the FAT domain are sensitive to changes in pH over a physiological pH range. In particular, regions of the FAT domain previously shown to regulate phosphorylation of Y926 as well as regions near Y1008 show pH-dependent dynamics on the μs-ms time scale.
Stellenwert der Routine-Computertomographie bei der akuten Sigmadivertikulitis
Creators: name: Bittkau, Charlotte
Publisher: name: Universität Rostock
Year: 2020
Subjects: subject: 610 Medical sciences Medicine

description: Die akute Sigmadivertikulitis ist eine der häufigsten Pathologien des Gastrointestinaltrakts der westlichen Welt und stellt mit steigenden Inzidenzen und zunehmenden Hospitalisierungsraten eine große Belastung für unser Gesundheitssystem dar. Die Durchführung einer Computertomographie ist trotz hoher Strahlenbelastung und hoher Kosten immer noch der weltweite Goldstandard in der Diagnostik dieser Erkrankung. Ziel der Arbeit war es, diesen Stellenwert der Computertomographie bei der akuten Sigmadivertikulitis zu überprüfen und einem diagnostischen Vorgehen ohne Routine-CT gegenüberzustellen.
(100647) Thomas Watkins Baker
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Holographic measurement in CFT thermofield doubles
Creators: name: Antonini, Stefano
name: Grado-White, Brianna
name: Jian, Shao-Kai
name: Swingle, Brian
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We extend the results of arXiv:2209.12903 by studying local projective measurements performed on subregions of two copies of a CFT${}_2$ in the thermofield double state and investigating their consequences on the bulk double-sided black hole holographic dual. We focus on CFTs defined on an infinite line and consider measurements of both finite and semi-infinite subregions. In the former case, the connectivity of the bulk spacetime is preserved after the measurement. In the latter case, the measurement of two semi-infinite intervals in one CFT or of one semi-infinite interval in each CFT can destroy the Einstein-Rosen bridge and disconnect the bulk dual spacetime. In particular, we find that a transition between a connected and disconnected phase occurs depending on the relative size of the measured and unmeasured subregions and on the specific Cardy state the measured subregions are projected on. We identify this phase transition as an entangled/disentangled phase transition of the dual CFT system by computing the post-measurement holographic entanglement entropy between the two CFTs. We also find that bulk information encoded in one CFT in the absence of measurement can sometimes be reconstructed from the other CFT when a measurement is performed, or can be erased by the measurement. Finally, we show that a purely CFT calculation of the Renyi entropy using the replica trick yields results compatible with those obtained in our bulk analysis.
description: 55 pages, 22 figures
Multimodale MRT-Analysen des cholinergen basalen Vorderhirns über das Alzheimerspektrum
Creators: name: Herdick, Meret
Publisher: name: Universität Rostock
Year: 2021
Subjects: subject: 610 Medical sciences Medicine

description: Ziel der Arbeit war es, die Wertigkeit für die Frühdiagnose einer Alzheimer Erkrankung in der präklinischen Phase von drei verschiedenen MRT-Modalitäten zu testen. Analysiert wurden funktionelle Konnektivität (FC), mittlere Diffusivität (MD) und Volumen im cholinergen basalen Vorderhirn, wobei eine Bestimmung der Amyloidveränderungen aus dem Liquor einbezogen wurde. Zur FC-Analyse standen 477, zur DTI-Analyse standen 243 Personendatensätze zur Verfügung. Weder die FC noch die MD zeigte eine relevante Differenzierung der Gruppen im präklinischen Bereich.
Deviation inequalities for martingales with applications to linear regressions and weak invariance principles
Creators: name: Fan, Xiequan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60G42, 60E15, 60F10

description: Using changes of probability measure developed by \mbox{Grama} and Haeusler (Stochastic Process.\ Appl., 2000), we obtain two generalizations of the deviation inequalities of Lanzinger and Stadtmüller (Stochastic Process.\ Appl., 2000) and Fuk and Nagaev (Theory Probab. Appl., 1971) to the case of martingales. Our inequalities recover the best possible decaying rate of independent case. Applications to linear regressions and weak invariance principles for martingales are provided.
Interaction of the Histone mRNA Hairpin with Stem–Loop Binding Protein (SLBP) and Regulation of the SLBP–RNA Complex by Phosphorylation and Proline Isomerization
Creators: name: Marzluff, William F.
name: Thapar, Roopa
name: Tonelli, Marco
name: Lam, Tukiet T.
name: Zhang, Minyou
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: In metazoans, the majority of histone proteins are generated from replication-dependent histone mRNAs. These mRNAs are unique in that they are not polyadenylated but have a stem-loop structure in their 3′ untranslated region. An early event in 3′ end formation of histone mRNAs is the binding of Stem-Loop Binding Protein (SLBP) to the stem-loop. Here we provide insight into the mechanism by which SLBP contacts the histone mRNA. There are two binding sites in the SLBP RBD for the histone mRNA hairpin. The first binding site (Glu129-Val158) consists of a helix-turn-helix (HTH) motif that likely recognizes the unpaired uridines in the loop of the histone hairpin and upon binding, destabilizes the first G-C base-pair at the base of the stem. The second binding site lies between residues Arg180-Pro200 which appears to recognize the second G-C basepair from the base of the stem and possibly regions flanking the stem-loop. We show that the SLBP-histone mRNA complex is regulated by threonine phosphorylation and proline isomerization in a conserved TPNK sequence that lies between the two binding sites. Threonine phosphorylation increases the affinity of SLBP for histone mRNA by slowing the off-rate for complex dissociation whereas the adjacent proline acts as a critical hinge that may orient the second binding site for formation of a stable SLBP-histone mRNA complex. The NMR and kinetic studies presented here provide a framework for understanding how SLBP recognizes histone mRNA and highlight possible structural roles of phosphorylation and proline isomerization in RNA-binding proteins in remodeling ribonucleoprotein complexes.
Photo-mediated oxygen atom transfer and light-induced organocatalytic and transition metal-catalyzed amination reactions
Creators: name: Täufer, Tobias
Publisher: name: Universität Rostock
Year: 2021
Subjects: subject: 540 Chemistry & allied sciences

description: Die Arbeit beschreibt die Desoxygenierung verschiedener Pyrimidopteridin-N-Oxid-Derivate, deren photophysikalischen Untersuchungen sowie deren unterschiedliche Anwendung und mechanistischen Untersuchungen der metallfreie Hydroaminierung. Zusätzlich werden photophysikalische und elektrochemischen Eigenschaften von Pyridin-N-Oxid-Derivaten als Sauerstofftransferreagenz untersucht und die Umwandlung in das (Methylsulfonyloxy)pyridiniummethansulfonat beschrieben. Zuletzt wird eine Palladium-katalysierte C-N-Bindungsbildung zwischen Dimethylaminen und Aryltriflaten diskutiert.
Manifolds with almost contact 3-structure and metrics of Hermitian-Norden type
Creators: name: Manev, Mancho
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: Primary 53C15, 53C50, Secondary 53C26

description: It is introduced a differentiable manifold with almost contact 3-structure which consists of an almost contact metric structure and two almost contact B-metric structures. The product of this manifold and a real line is an almost hypercomplex manifold with Hermitian-Norden metrics. It is proven that the introduced manifold of cosymplectic type is at. Some examples of the studied manifolds are given.
description: 11 pages, revised, some parts are separated and further developed
Proteolytic Regulation of the Mitochondrial cAMP-Dependent Protein Kinase
Creators: name: Shell, Jennifer R.
name: Lawrence, David S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The mitochondrial cAMP-dependent protein kinase (PKA) is activatable in a cAMP-independent fashion. The regulatory (R) subunits of the PKA holoenzyme (R2C2), but not the catalytic (C) subunits, suffer proteolysis upon exposure of bovine heart mitochondria to digitonin, Ca2+, and a myriad of electron transport inhibitors. Selective loss of both the RI- and RII-type subunits was demonstrated via western blot analysis and activation of the C subunit was revealed by phosphorylation of a validated PKA peptide substrate. Selective proteolysis transpires in a calpain-dependent fashion as demonstrated by exposure of the R and C subunits of PKA to calpain and by attenuation of R and C subunit proteolysis in the presence of calpain inhibitor I. By contrast, exposure of mitochondria to cAMP fails to promote R subunit degradation, although it does result in enhanced C subunit catalytic activity. Treatment of mitochondria with electron transport chain inhibitors rotenone, antimycin A, sodium azide, and oligomycin, as well as an uncoupler of oxidative phosphorylation, also elicits enhanced C subunit activity. These results are consistent with the notion that signals, originating from cAMP-independent sources, elicit enhanced mitochondrial PKA activity.
(100648) George Edwin Baker
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
null polyphonic novel in contemporary British fiction
Creators: name: Yeşilbaş, Emre
Publisher: name: Universität Rostock
Year: 2020
Subjects: subject: 420 English
subject: 800 Literature & rhetoric
subject: 820 English & Old English literatures

description: This thesis offers an alternative history of contemporary British fiction by centralizing the conception of genre as a ‘way of seeing and conceptualizing the world. By recontextualizing and reintroducing the polyphonic novel as a distinctive, emergent (cf. Williams) genre that mediates the contradictions of neoliberal individualism and its cultural manifestation, postmodernism, this thesis offers a distinctive perspective on cultural diversity and social fragmentation in contemporary Britain and aims to complement aesthetic and postmodernist literary histories that prioritize diversity.
The Second Chromophore in Drosophila Photolyase/Cryptochrome Family Photoreceptors
Creators: name: Sancar, Aziz
name: Selby, Christopher P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: The photolyase/cryptochrome family of proteins are FAD-containing flavoproteins which carry out blue-light dependent functions including DNA repair, plant growth and development, and regulation of the circadian clock. In addition to FAD, many members of the family contain a second chromophore which functions as a photoantenna, harvesting light and transferring the excitation energy to FAD and thus increasing the efficiency of the system. The second chromophore is methenyltetrahydrofolate (MTHF) in most photolyases characterized to date and FAD, FMN, or 5-deazariboflavin in others. To date no second chromophore has been identified in cryptochromes. Drosophila contains 3 members of the cryptochrome/photolyase family: cyclobutane pyrimidine dimer (CPD) photolyase, (6-4) photoproduct photolyase, and cryptochrome. We developed an expression system capable of incorporating all known second chromophores into the cognate cryptochrome/photolyase family members. Using this system we demonstrate that Drosophila CPD photolyase and (6-4) photolyase employ 5-deazariboflavin as their second chromophore but Drosophila cryptochrome, which is evolutionarily closer to (6-4) photolyase than the CPD photolyase, lacks a second chromophore.
Asymptotically charged BTZ Black Holes in Gravity's Rainbow
Creators: name: Hendi, Seyed Hossein
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Motivated by the wide applications of BTZ black holes and interesting results of gravity's rainbow, we consider three dimensional rainbow solutions and investigate their thermodynamic properties. In addition to investigate black holes thermodynamics related to AdS/CFT correspondence, one may regard gravity's rainbow to to encode quantum gravity effects into the black hole solutions. We take into account the various models of linear and nonlinear electrodynamics and study their effects on the gravity's rainbow spacetime. We also examine thermal stability and find that obtained three dimensional rainbow black holes are thermally stable.
description: 8 pages, no figure, Accepted in GERG
Identification of novel integrin binding partners for CIB1: structural and thermodynamic basis of CIB1 promiscuity
Creators: name: Leisner, Tina M.
name: Wu, Yi I.
name: Dokholyan, Nikolay V.
name: Black, Justin L.
name: Freeman, Thomas C.
name: Bray, Holly G.
name: Dagliyan, Onur
name: Parise, Leslie V.
name: Tripathy, Ashutosh
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The short cytoplasmic tails of the α and β chains of integrin adhesion receptors regulate integrin activation and cell signaling. Significantly less is known about proteins that bind to α-integrin cytoplasmic tails (CTs) than β-CTs to regulate integrins. CIB1 was previously identified as an αIIb binding partner that inhibits agonist-induced activation of the platelet-specific integrin, αIIbβ3. A sequence alignment of all α-integrin CTs revealed that key residues in the CIB1 binding site on αIIb are well-conserved, and was used to delineate a consensus binding site (I/L-x-x-x-L/M-W/Y-K-x-G-F-F). Because the CIB1 binding site on αIIb is conserved in all α-integrins, and CIB1 expression is ubiquitous, we asked if CIB1 could interact with other α-integrin CTs. We predicted that multiple α-integrin CTs were capable of binding to the same hydrophobic binding pocket on CIB1 with docking models generated by all-atom replica exchange discrete molecular dynamics. After demonstrating novel in vivo interactions between CIB1 and other whole integrin complexes with co-immunopreceipitations, we validated the modeled predictions with solid-phase competitive binding assays showing that other α-integrin CTs compete with the αIIb CT for binding to CIB1 in vitro. Isothermal titration calorimetry measurements indicated that this binding is driven by hydrophobic interactions and depends on residues in the CIB1 consensus binding site. These new mechanistic details of CIB1-integrin binding imply that CIB1 could bind to all integrin complexes and act as a broad regulator of integrin function.
Heterogeneous Combustion of AP / HTPB / RDX with Detailed Kinetics
Creators: name:  PIERRE BERNIGAUD
name:   DMITRY DAVIDENKO
name:   LAURENT CATOIRE
Publisher: name: Proceedings of the Aerospace Europe Conference - EUCASS - CEAS - 2023
Year: 2023
Subjects: AP
HTPB
RDX
COMPOSITE PROPELLANTS
HETEROGENEOUS COMBUSTION
DETAILED KINETICS

description: In this work, the effect of hexogen (RDX) inclusion in conventional ammonium perchlorate (AP)/ hydroxy 1terminated polybutadiene (HTPB) composite propellants is investigated. To this end, a detailed gas-phase kinetic mechanism for AP/HTPB/RDX combustion is assembled and tested. The combustion of a single RDX particle surrounded by a layer of homogenized AP/HTPB binder is simulated with this kinetic model for various pressures and RDX particle sizes. A phenomenological description of the heterogeneous flame structure forming above the propellant is proposed. Two combustion modes are identified: hot and mild. Critical conditions for the combustion mode change are determined in terms of ambient pressure and RDX particle size.
(100649) Eliza Jane Baker
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Vergleichende Untersuchung von biodegradierbaren PLLA/P4HB-Polymerstents mit und ohne SIR-eluierender Beschichtung und unter der Gabe einer oralen Hochdosistherapie Atorvastatin im peripheren arteriellen Gefäßsystem des Landschweins
Creators: name: Moreth, Felix
Publisher: name: Universität Rostock
Year: 2021
Subjects: subject: 610 Medical sciences Medicine

description: Die in dieser Studie dargelegten Ergebnisse dokumentieren einen weiteren Schritt in der Entwicklung bioresorbierbarer PLLA/P4HB-Stents als Alternative zu herkömmlichen permanenten 316L-Metallstents. Bekannte Defizite, wie die im Vergleich zu permanenten Stents vermehrt beobachtete reaktive inflammatorische Reaktion oder die im Applikationsprozess lediglich indirekte Visualisierung der Stents, konnten durch Inkorporation eines antiproliferativen Agens und einer Röntgenmarkierung verbessert und das etablierte Tiermodell zur transluminalen Applizierung neuer PLLA/P4HB-Stents optimiert werden.
Kinetic Mechanism of Human Histidine Triad Nucleotide Binding Protein 1
Creators: name: Chou, Tsui Fen
name: Wagner, Carston R.
name: Adams, Joseph
name: Park, Chin Ju
name: Wolfenden, Richard
name: Zhou, Xin
name: Aubol, Brandon E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Human histidine triad nucleotide binding protein 1 (hHint1) is a member of a ubiquitous and ancient branch of the histidine triad protein superfamily. hHint1 is a homodimeric protein that catalyzes the hydrolysis of model substrates, phosphoramidate and acyl adenylate, with a high efficiency. Recently, catalytically inactive hHint1 has been identified as the cause of inherited peripheral neuropathy [Zimon, M., et al. (2012) Nat. Genet. 44, 1080-1083]. We have conducted the first detailed kinetic mechanistic studies of hHint1 and have found that the reaction mechanism is consistent with a double-displacement mechanism, in which the active site nucleophile His112 is first adenylylated by the substrate, followed by hydrolysis of the AMP-enzyme intermediate. A transient burst phase followed by a linear phase from the stopped-flow fluorescence assay indicated that enzyme adenylylation was faster than the subsequent intermediate hydrolysis and product release. Solvent viscosity experiments suggested that both chemical transformation and diffusion-sensitive events (product release or protein conformational change) limit the overall turnover. The catalytic trapping experiments and data simulation indicated that the true koff rate of the final product AMP is unlikely to control the overall kcat. Therefore, a protein conformational change associated with product release is likely rate-limiting. In addition, the rate of Hint1 adenylylation was found to be dependent on two residues with pKa values of 6.5 and 8, with the former pKa agreeing well with the nuclear magnetic resonance titration results for the pKa of the active site nucleophile His112. In comparison to the uncatalyzed rates, hHint1 was shown to enhance acyl-AMP and AMP phosphoramidate hydrolysis by 10(6)-10(8)-fold. Taken together, our analysis indicates that hHint1 catalyzes the hydrolysis of phosphoramidate and acyl adenylate with high efficiency, through a mechanism that relies on rapid adenylylation of the active residue, His112, while being partially rate-limited by intermediate hydrolysis and product release associated with a conformational change. Given the high degree of sequence homology of Hint proteins across all kingdoms of life, it is likely that their kinetic and catalytic mechanisms will be similar to those elucidated for hHint1.
Behavioral patterns of individuals and groups during co-located collaboration on large, high-resolution displays
Creators: name: Sigitov, Anton
Publisher: name: Universität Rostock
Year: 2021
Subjects: subject: 004 Data processing Computer sciences

description: Collaboration among multiple users on large screens leads to complicated behavior patterns and group dynamics. To gain a deeper understanding of collaboration on vertical, large, high-resolution screens, this dissertation builds on previous research and gains novel insights through new observational studies. Among other things, the collected results reveal new patterns of collaborative coupling, suggest that territorial behavior is less critical than shown in previous research, and demonstrate that workspace awareness can also negatively affect the effectiveness of individual users.
(100645) Jane Gallagher
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Random walk hierarchy measure: What is more hierarchical, a chain, a tree or a star?
Creators: name: Czégel, Dániel
name: Palla, Gergely
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: FOS: Physical sciences

description: Signs of hierarchy are prevalent in a wide range of systems in nature and society. One of the key problems is quantifying the importance of hierarchical organisation in the structure of the network representing the interactions or connections between the fundamental units of the studied system. Although a number of notable methods are already available, their vast majority is treating all directed acyclic graphs as already maximally hierarchical. Here we propose a hierarchy measure based on random walks on the network. The novelty of our approach is that directed trees corresponding to multi level pyramidal structures obtain higher hierarchy scores compared to directed chains and directed stars. Furthermore, in the thermodynamic limit the hierarchy measure of regular trees is converging to a well defined limit depending only on the branching number. When applied to real networks, our method is computationally very effective, as the result can be evaluated with arbitrary precision by subsequent multiplications of the transition matrix describing the random walk process. In addition, the tests on real world networks provided very intuitive results, e.g., the trophic levels obtained from our approach on a food web were highly consistent with former results from ecology.
A method to generate a constrained terrain following trajectory using circular path
Creators: name:  HYUNJU LEE
name:   SANGCHUL LEE
Publisher: name: Proceedings of the Aerospace Europe Conference - EUCASS - CEAS - 2023
Year: 2023
Subjects: TERRAIN FOLLOWING
TRAJECTORY
PATH

description: Terrain following(TF) flight could minimize the risks to be revealed by enemy while having proper trajectory. There are some constraints on initial position and terminal position of TF trajectory because IF trajectory should reflect the terrain profile and the aircraft position. In this paper, the method to generate constrained IF trajectory is proposed. The circular path method is conducted to IF path which is generated by using 3-mask morphology. After generating IF path, it is converted into IF trajectory. Generated IF trajectory is confirmed that the aircraft could follow by the tracking simulation.
Nonconserved Active Site Residues Modulate CheY Autophosphorylation Kinetics and Phosphodonor Preference
Creators: name: Bourret, Robert B.
name: Immormino, Robert M.
name: Silversmith, Ruth E.
name: Thomas, Stephanie A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: In two-component signal transduction, response regulator proteins contain the catalytic machinery for their own covalent phosphorylation and can catalyze phosphotransfer from a partner sensor kinase or autophosphorylate using various small molecule phosphodonors. Although response regulator autophosphorylation is physiologically relevant and a powerful experimental tool, the kinetic determinants of the autophosphorylation reaction and how those determinants might vary for different response regulators and phosphodonors are largely unknown. We characterized the autophosphorylation kinetics of 21 variants of the model response regulator Escherichia coli CheY that contained substitutions primarily at nonconserved active site positions D+2 (CheY residue 59) and T+2 (CheY residue 89), two residues C-terminal to conserved D57 and T87, respectively. Overall, the CheY variants exhibited a >105-fold range of rate constants (kphos/KS) for reaction with phosphoramidate, acetyl phosphate, or monophosphoimidazole, with the great majority of rates enhanced over wild type CheY. Although phosphodonor preference varied substantially, nearly all the CheY variants reacted faster with phosphoramidate than acetyl phosphate. Correlation between increased positive charge of the D+2/T+2 side chains and faster rates indicated electrostatic interactions are a kinetic determinant. Moreover, sensitivities of rate constants to ionic strength indicated that both long-range and localized electrostatic interactions influence autophosphorylation kinetics. Increased nonpolar surface area of the D+2/T+2 side chains also correlated with enhanced autophosphorylation rate, especially for reaction with phosphoramidate and monophosphoimidazole. Computer docking suggested that highly accelerated monophosphoimidazole autophosphorylation rates for CheY variants with a tyrosine at position T+2 likely reflect structural mimicry of phosphotransfer from the sensor kinase histidyl phosphate.
title: Веб-технологии: основы верстки сайтов
Creators: name: ELS IPR BOOKS
Publisher: name: Южно-Уральский технологический университет
Year: 2021

description: Учебное пособие включает в себя теоретический материал, методические рекомендации по выполнению практических работ, перечень вопросов для самопроверки, перечень вопросов для углубленного изучения темы, задания для выполнения проектов, списки рекомендуемой литературы и ссылки на полезные Интернет-ресурсы. Пособие можно использовать для самостоятельного изучения разделов дисциплин «Мультимедиа технологии и компьютерная графика» и «Основы веб-технологий», при выполнении практических работ, в проектной деятельности, а также при подготовке к экзаменам. Учебное пособие соответствует ФГОС ВО по направлению подготовки 09.03.02 «Информационные системы и технологии» (квалификация (степень) «бакалавр»). Учебное пособие предназначено для студентов, обучающихся по направлению 09.03.02 «Информационные системы и технологии», всех форм обучения.
The Development of the Non-Oil Sector and Possible Public Finances in Azerbaijan Effects
Creators: name: Asadov, Asad
Publisher: name: Zenodo
Year: 2023
Subjects: Non Oil Sector, Fiscal Policies

description: As a newly independent country, Azerbaijan has experienced the effects of globalization more in the transition period to the free market. Although it was a country that tried to take control of the economy until the 2000s, its economy started to grow after the 2000s and has become a prominent country in the region in recent years. How accurate the implemented fiscal policies are and how successful the income distribution is among the citizens has been the main subject of this study.
Potenzialanalyse zur Stickoxid- und Methanemissionsreduzierung in mittelschnelllaufenden Dual-Fuel-Motoren unter Anwendung von Mehrfacheinspritzstrategien
Creators: name: Henke, Björn
Publisher: name: Universität Rostock
Year: 2021
Subjects: subject: 620 Engineering & allied operations

description: Zur Treibhausgasreduzierung im maritimen Sektor kommen zunehmend Dual-Fuel-Motoren zum Einsatz. Prozessbedingt kommt es in diesen Motoren zu einem Trade-Off zwischen den gesetzlich limitierten Stickoxid- und den treibhausgasrelevanten Methanemissionen. Mithilfe experimenteller Analysen zum Betriebs- und Sprayverhalten eines Wide-Range-injektors und motorischer Untersuchungen an einem Einzylinder-Forschungsmotor konnten unter Anwendung von Mehrfacheinspritzstrategien sehr hohe Potenziale zum Erreichen zukünftiger Emissionsziele erarbeitet werden.
Symmetry fractionalization and twist defects
Creators: name: Tarantino, Nicolas
name: Lindner, Netanel H.
name: Fidkowski, Lukasz
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mathematical Physics (math-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Topological order in two dimensions can be described in terms of deconfined quasiparticle excitations - anyons - and their braiding statistics. However, it has recently been realized that this data does not completely describe the situation in the presence of an unbroken global symmetry. In this case, there can be multiple distinct quantum phases with the same anyons and statistics, but with different patterns of symmetry fractionalization - termed symmetry enriched topological (SET) order. When the global symmetry group $G$, which we take to be discrete, does not change topological superselection sectors - i.e. does not change one type of anyon into a different type of anyon - one can imagine a local version of the action of $G$ around each anyon. This leads to projective representations and a group cohomology description of symmetry fractionalization, with $H^2(G,{\cal A})$ being the relevant group. In this paper, we treat the general case of a symmetry group $G$ possibly permuting anyon types. We show that despite the lack of a local action of $G$, one can still make sense of a so-called twisted group cohomology description of symmetry fractionalization, and show how this data is encoded in the associativity of fusion rules of the extrinsic `twist' defects of the symmetry. Furthermore, building on work of Hermele, we construct a wide class of exactly solved models which exhibit this twisted symmetry fractionalization, and connect them to our formal framework.
description: 28 pages, 18 figures. Version 2 contains all modifications made during the review process. It now matches the version found in the New Journal of Physics
Phosphatidylserine-Induced Factor Xa Dimerization and Binding to Factor Va Are Competing Processes in Solution
Creators: name: Majumder, Rinku
name: Lentz, Barry R.
name: Koklic, Tilen
name: Rezaie, Alireza R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: A soluble, short chain phosphatidylserine, 1,2-dicaproyl-sn-glycero-3-phospho-L-serine (C6PS), binds to discrete sites on FXa, FVa, and prothrombin to alter their conformations, to promote FXa dimerization (Kd ~ 14 nM), and to enhance both the catalytic activity of FXa and the cofactor activity of FVa. In the presence of calcium, C6PS binds to two sites on FXa, one in the epidermal growth factor like (EGF) domain and one in the catalytic domain; the latter interaction is sensitive to Na+ binding and probably represents a protein recognition site. Here we ask whether dimerization of FXa and its binding to FVa in the presence of C6PS are competitive processes. We monitored FXa activity at 5, 20 and 50 nM FXa while titrating with FVa in the presence of 400 µM C6PS and 3 or 5 mM Ca2+ to show that the apparent Kd of FVa-FXa interaction increased with increasing FXa concentration at 5 mM Ca2+, but the Kd was only slightly affected at 3 mM Ca2+. A mixture of 50 nM FXa and 50 nM FVa in the presence of 400 µM C6PS yielded both Xa homodimers and Xa ·Va heterodimers but no FXa dimers bound to FVa. A mutant FXa (R165A) that has reduced prothrombinase activity showed both reduced dimerization (Kd~147 nM) and reduced FVa binding (apparent Kd, = 58, 92 and 128 nM, respectively for 5, 20 and 50 nM R165A FXa). Native gel electrophoresis showed that the GLA-EGFNC fragment of FXa (lacking the catalytic domain) neither dimerized nor formed a complex with FVa in the presence of 400 µM C6PS and 5 mM Ca2+. Our results demonstrate that the dimerization site and FVa binding site are both located in the catalytic domain of FXa and that these sites are linked thermodynamically.
(100622) Ann Avery
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Einfluss des Beschulungsortes auf das Selbstkonzept von Lernenden mit sonderpädagogischem Förderbedarf
Creators: name: Müller, Anna
Publisher: name: Universität Rostock
Year: 2021
Subjects: subject: 370 Education

description: Ausgehend vom bio-ökologischen Modell (Bronfenbrenner & Morris, 1998) ist anzunehmen, dass Umweltsysteme und somit auch das Schulsetting das Selbstkonzept von Kindern als Teil ihrer Persönlichkeitsentwicklung stark beeinflussen. Die bisherige Forschungslage zum Einfluss des Schulsettings auf das Selbstkonzept von Lernenden mit sonderpädagogischem Förderbedarf erscheint widersprüchlich. In der vorliegenden Arbeit werden dieser Effekt sowie mögliche Einflussvariablen durch eine Metaanalyse untersucht. Dafür wurden 24 nationale und internationale Studien aus den Jahren 1990 bis 2019 einbezogen.
LOX recirculation characteristics of propellant feeding system with a filter installed at tank outlet
Creators: name:  OH-SUNG KWON
name:   JOONG-YOUP LEE
Publisher: name: Proceedings of the Aerospace Europe Conference - EUCASS - CEAS - 2023
Year: 2023
Subjects: LOX RECIRCULATION
PROPELLANT FEEDING SYSTEM
CRYOGENIC PROPELLANT

description: This paper describes the results of the propellant recirculation test, which is one of the cryogenic propellant temperature control methods. The test was conducted in a sub scaled propellant feeding system test facility using liquid oxygen. The tank diameter is 1 m and a filter is installed at the tank outlet. The evaporation of liquid oxygen in the feeding pipe during standby, liquid oxygen recirculation flowrate according to the amount of helium injection, and the effect of the propellant filling rate and pressurization of the tank on recirculation were examined. The filter installed at the tank outlet greatly affected the recirculation characteristics of the cryogenic propellant.
Principles for Understanding the Accuracy of SHAPE-Directed RNA Structure Modeling
Creators: name: Karabiber, Fethullah
name: Hajdin, Christine E.
name: Weeks, Kevin M.
name: Favorov, Oleg V.
name: Mathews, David H.
name: Leonard, Christopher W.
name: Dokholyan, Nikolay V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Accurate RNA structure modeling is an important, incompletely solved, challenge. Single-nucleotide resolution SHAPE (selective 2'-hydroxyl acylation analyzed by primer extension) yields an experimental measurement of local nucleotide flexibility that can be incorporated as pseudo-free energy change constraints to direct secondary structure predictions. Prior work from our laboratory has emphasized both the overall accuracy of this approach and the need for nuanced interpretation of some apparent discrepancies between modeled and accepted structures. Recent studies by Das and colleagues [Kladwang et al., Biochemistry 50:8049 (2011) and Nat. Chem. 3:954 (2011)], focused on analyzing six small RNAs, yielded poorer RNA secondary structure predictions than expected based on prior benchmarking efforts. To understand the features that led to these divergent results, we re-examined four RNAs yielding the poorest results in this recent work – tRNAPhe, the adenine and cyclic-di-GMP riboswitches, and 5S rRNA. Most of the errors reported by Das and colleagues reflected non-standard experiment and data processing choices, and selective scoring rules. For two RNAs, tRNAPhe and the adenine riboswitch, secondary structure predictions are nearly perfect if no experimental information is included but were rendered inaccurate by the Das and colleagues SHAPE data. When best practices were used, single-sequence SHAPE-directed secondary structure modeling recovered ~93% of individual base pairs and greater than 90% of helices in the four RNAs, essentially indistinguishable from the mutate-and-map approach with the exception of a single helix in the 5S rRNA. The field of experimentally-directed RNA secondary structure prediction is entering a phase focused on the most difficult prediction challenges. We outline five constructive principles for guiding this field forward.
(100624) Edwin Avery
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Prävalenz und Progression kognitiver Dysfunktionen bei Patienten mit Vorhofflimmern nach Behandlung mittels Katheter- Ablation oder medikamentöser Therapie
Creators: name: Nitschke, Daniel
Publisher: name: Universität Rostock
Year: 2020
Subjects: subject: 610 Medical sciences Medicine

description: Vorhofflimmern (VHF) ist weltweit die häufigste Herzrhythmusstörung und ist vor allem bei älteren Menschen mit diversen Komorbiditäten vergesellschaftet. VHF geht mit einem erhöhten Risiko für Thrombembolien und demenziellen Erkrankungen durch Mikroinfarkte im Gehirn einher. Bei Patienten mit symptomatischem VHF wird eine Rhythmuskontrolle mit einem Antiarrythmikum oder eine Ablation empfohlen. In diesem Kontext wurde die Prävalenz und Progression kognitiver Dysfunktionen bei Patienten nach Katheterablation oder medikamentöser antiarrhythmischer Therapie untersucht.
SAMUTER Experiencias alternativas en los ámbitos de la vitivinicultura globalizada: DOP Rueda
Creators: name: Rodríguez, Eugenio Baraja
name: Arnáiz, Marta Martínez
name: Luque, Daniel Herrero
Publisher: name: Zenodo
Year: 2023
Subjects: SAMUTER, Sistema Agroalimentario, Rueda

description: Las experiencias alternativas en los ámbitos de la vitivinicultura globalizada DOP Rueda forma parte del proyecto SAMUTER (Sistemas Agroalimentarios Multifuncionales y Territorializados) (https://samuter.paisajeterritoriouam.es/). El territorio vitivinícola amparado por la DO Rueda, Castilla y León, España, constituye el arquetipo de la vitivinicultura productivista, moderna y globalizada del Duero. Especializada en vinos blancos, su variedad verdeja adquirió desde los años ochenta del pasado siglo un amplio reconocimiento internacional, justificando la expansión de los viñedos por las llanuras centrales del Duero, particularmente en las campiñas meridionales. Una estrategia basada en el aprovechamiento de las economías de escala y en la explotación de una marca reconocida para posicionarse en el mercado, han terminado por generar un paisaje homogéneo, de perfil productivista e industrial. Sin embargo, cada vez cobra más fuerza una visión alternativa de la vitivinicultura que combina el anclaje territorial (DOP) y la diferenciación del producto (los vinos únicos). Como forma de adaptación a los nuevos valores sociales y de mercado, se están desarrollando prácticas que se alejan del modelo productivista para apostar por la sostenibilidad, la multifuncionalidad y la singularidad de determinados pagos y formas de elaboración. Alternative experiences in the fields of globalised viticulture Rueda PDO is part of the SAMUTER project (Multifunctional and Territorialised Agri-food Systems) (https://samuter.paisajeterritoriouam.es/).

 The wine-growing territory covered by the Rueda PDO, Castilla y León, Spain, is the archetype of the productive, modern and globalised wine-growing of the Douro region. Specialising in white wines, its verdeja variety has gained wide international recognition since the 1980s, justifying the expansion of vineyards throughout the central plains of the Duero, particularly in the southern countryside. A strategy based on taking advantage of economies of scale and exploiting a recognised brand name to position themselves in the market has ended up generating a homogeneous landscape, with a productive and industrial profile. However, an alternative vision of winemaking that combines territorial anchoring (PDO) and product differentiation (unique wines) is increasingly gaining strength. As a way of adapting to new social and market values, practices are being developed that move away from the productivist model in favour of sustainability, multifunctionality and the uniqueness of certain vineyards and production methods.
(100616) Mary Eliza Mardon
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Damping Properties of the Hair Bundle
Creators: name: Baumgart, Johannes
name: Kozlov, Andrei S.
name: Risler, Thomas
name: Hudspeth, A. James
Publisher: name: arXiv
Year: 2015
Subjects: subject: Subcellular Processes (q-bio.SC)
subject: Biological Physics (physics.bio-ph)
subject: Computational Physics (physics.comp-ph)
subject: Fluid Dynamics (physics.flu-dyn)
subject: Quantitative Methods (q-bio.QM)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: The viscous liquid surrounding a hair bundle dissipates energy and dampens oscillations, which poses a fundamental physical challenge to the high sensitivity and sharp frequency selectivity of hearing. To identify the mechanical forces at play, we constructed a detailed finite-element model of the hair bundle. Based on data from the hair bundle of the bullfrog's sacculus, this model treats the interaction of stereocilia both with the surrounding liquid and with the liquid in the narrow gaps between the individual stereocilia. The investigation revealed that grouping stereocilia in a bundle dramatically reduces the total drag. During hair-bundle deflections, the tip links potentially induce drag by causing small but very dissipative relative motions between stereocilia; this effect is offset by the horizontal top connectors that restrain such relative movements at low frequencies. For higher frequencies the coupling liquid is sufficient to assure that the hair bundle moves as a unit with a low total drag. This work reveals the mechanical characteristics originating from hair-bundle morphology and shows quantitatively how a hair bundle is adapted for sensitive mechanotransduction.
description: AIP Conference Proceeding
Municipes Vangiones
Creators: name: Nuber, Hans Ulrich
Publisher: name: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts
Year: 2023

description: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts, Bd. 50 (1972)