cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Sample size for multiple hypothesis testing in biosimilar development
Creators: name: Mielke, Johanna
name: Jones, Byron
name: Jilma, Bernd
name: König, Franz
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: In biosimilar development, often multiple endpoints within a study, multiple doses and routes of administration or multiple studies in different populations are considered. However, a regulatory requirement is that equivalence of the biosimilar and the reference drug has to be shown for all comparisons, which would typically require a large sample size for a clinical development program. One way that the sample size can be reduced, when m null hypotheses are to be considered, is to require that only k < m null hypotheses have to be rejected to get approval. In fact, this is a realistic requirement, since despite their guidelines the European Medicines Agency (EMA) has already approved applications for biosimilars where not all primary endpoints met the equivalence criteria. In this paper we investigate the properties of the test for the success of at least k out of m endpoints and discuss several multiplicity adjustments that might be useful in practice. We illustrate the impact of multiple hypothesis testing on the sample size using three real world examples of pharmacokinetic (PK) studies that were submitted to the EMA for the approval of biosimilars.
An alternative conformation of human TrpRS suggests a role of zinc in activating non-enzymatic function
Creators: name: Xiaoling Xu
name: Huihao Zhou
name: Quansheng Zhou
name: Hong, Fei
name: My-Nuong Vo
name: Wanqiang Niu
name: Zhiguo Wang
name: Xiaolin Xiong
name: Kanaha Nakamura
name: Wakasugi, Keisuke
name: Schimmel, Paul
name: Yang, Xiang-Lei
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Neuroscience
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: 60506 Virology
subject: FOS: Biological sciences
subject: Computational Biology

description: Tryptophanyl-tRNA synthetase (TrpRS) in vertebrates contains a N-terminal extension in front of the catalytic core. Proteolytic removal of the N-terminal 93 amino acids gives rise to T2-TrpRS, which has potent anti-angiogenic activity mediated through its extracellular interaction with VE-cadherin. Zinc has been shown to have anti-angiogenic effects and can bind to human TrpRS. However, the connection between zinc and the anti-angiogenic function of TrpRS has not been explored. Here we report that zinc binding can induce structural relaxation in human TrpRS to facilitate the proteolytic generation of a T2-TrpRS-like fragment. The zinc-binding site is likely to be contained within T2-TrpRS, and the zinc-bound conformation of T2-TrpRS is mimicked by mutation H130R. We determined the crystal structure of H130R T2-TrpRS at 2.8 Å resolution, which reveals drastically different conformation from that of wild-type (WT) T2-TrpRS. The conformational change creates larger binding surfaces for VE-cadherin as suggested by molecular dynamic simulations. Surface plasmon resonance analysis indicates more than 50-fold increase in binding affinity of H130R T2-TrpRS for VE-cadherin, compared to WT T2-TrpRS. The enhanced interaction is also confirmed by a cell-based binding analysis. These results suggest that zinc plays an important role in activating TrpRS for angiogenesis regulation.
Biological events and molecular signaling following MLKL activation during necroptosis
Creators: name: Gong, Yi-Nan
name: Guy, Cliff
name: Crawford, Jeremy Chase
name: Green, Douglas R.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Necroptosis is a form of programmed necrotic cell death mediated by the kinase RIPK3 and its substrate MLKL. MLKL, which displays plasma membrane (PM) pore-forming activity upon phosphorylation, functions as the executioner during necroptosis. Thus, it was previously assumed that MLKL phosphorylation is the endpoint of the necroptotic signaling pathway. Here, we summarize several events that characterize the dying necroptotic cells after MLKL phosphorylation, including Ca2+ influx, phosphatidylserine (PS) externalization, PM repair by ESCRT-III activation, and the final compromise of PM integrity. These processes add several unexpected regulatory events downstream of MLKL signaling. We have also observed that CoCl2, which may mimic hypoxia, can induce necroptosis, which suggests that in vivo triggers of necroptosis might include a transient lack of O2.
title: ADCO, Cartulaire de Cîteaux pour les domaines de Beaune (XVe siècle), Cart. 177 (11 H 289), 197 folios, f. 0391
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2015
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire

description: Cartulaire de Cîteaux pour les domaines de Beaune (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 177 (11 H 289), 197 folios, f. 0391, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour les possessions d’Izeure (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 177 (11 H 289), 197 folios, f. 0391, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Additional file 1 of Korea Hypertension Fact Sheet 2023: analysis of nationwide population-based data with a particular focus on hypertension in special populations
Creators: name: Kim, Hyeon Chang
name: Lee, Hokyou
name: Lee, Hyeok-Hee
name: Son, Dasom
name: Cho, Minsung
name: Shin, Sojung
name: Seo, Yeeun
name: kim, Eun-Jin
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy

description: Additional file 1.
Aminoacyl-tRNA Quality Control is Required for Efficient Activation of the TOR Pathway Regulator Gln3p
Creators: name: Mohler, Kyle
name: Mann, Rebecca
name: Kyle, Amanda
name: Reynolds, Noah
name: Ibba, Michael
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: The aminoacylation status of the cellular tRNA pool regulates both general amino acid control (GAAC) and target of rapamycin (TOR) stress response pathways in yeast. Consequently, fidelity of translation at the level of aminoacyl-tRNA synthesis plays a central role in determining accuracy and sensitivity of stress responses. To investigate effects of translational quality control (QC) on cell physiology under stress conditions, phenotypic microarray analyses were used to identify changes in QC deficient cells. Nitrogen source growth assays showed QC deficient yeast grew differently compared to WT. The QC deficient strain was more tolerant to caffeine treatment than wild type through altered interactions with the TOR and GAAC pathways. Increased caffeine tolerance of the QC deficient strain was consistent with the observation that the activity of Gln3p, a transcription factor controlled by the TOR pathway, is decreased in the QC deficient strain compared to WT. GCN4 translation, which is typically repressed in the absence of nutritional stress, was enhanced in the QC deficient strain through TOR inhibition. QC did not impact cell cycle regulation; however, the chronological lifespan of QC deficient yeast strains decreased compared to wild type, likely due to translational errors and alteration of the TOR-associated regulon. These findings support the idea that changes in translational fidelity provide a mechanism of cellular adaptation by modulating TOR activity. This, in turn, supports a central role for aminoacyl-tRNA synthesis QC in the integrated stress response by maintaining the proper aa-tRNA pools necessary to coordinate the GAAC and TOR.
QTL identification and candidate gene identification for monoterpene content in grape (Vitis vinifera L.) berries
Creators: name: Lin, Hong
name: Guo, Yinshan
name: Yang, Xiaoxu
name: Kondo, Satoru
name: Zhao, Yuhui
name: Liu, Zhendong
name: Li, Kun
name: Guo, Xiuwu
Publisher: name: VITIS - Journal of Grapevine Research
Year: 2020

description: Great progress has been made during the last decade in clarifying the molecular details of aroma accumulation in grape berries. However, the multigene complex controlling monoterpene accumulation in grape is not well understood. To shed light on this issue, the grapes of 149 F1 progenies from the cross 87-1 (Vitis vinifera L.) × 9-22 (Vitis vinifera L.) were characterized at the mature stage for three representative free monoterpenes during five growing seasons. A total of 202, 184 and 255 polymorphic SSR (simple sequence repeat) markers were contracted on the maternal 87-1, paternal 9-22 and consensus genetic maps, respectively. On the consensus map, we confirmed a major QTL (quantitative trait locus) for free linalool, nerol and α-terpineol content on linkage group (LG) 5, and a stable QTL for free linalool and α-terpineol was detected on LG 10. In addition, two new stable QTLs for free monoterpene (linalool, nerol and α-terpineol) contents were identified on LG 11 and LG 18 that explained up to 42.5 % of the total variance. Eleven promising candidate genes related to pentatricopeptide repeat (PPR)-containing proteins, seed maturation protein, RING finger protein, and AP2/ERF transcription factors might be potentially involved in monoterpene accumulation. The stable QTLs and candidate genes identified in this study provide new insights into free monoterpene accumulation in grape.
description: VITIS - Journal of Grapevine Research, Vol. 59 No. 1 (2020): Vitis
A rapid and inexpensive RNA-extraction method for high-throughput virus detection in grapevine
Creators: name: Steinmetz, N.
name: Michl, G.
name: Maixner, M.
name: Hoffmann, C.
Publisher: name: VITIS - Journal of Grapevine Research
Year: 2020

description: The extraction of RNA from grapevine tissue is a crucial step for virus diagnostics via multiplex reverse transcription-polymerase chain reaction (mRT-PCR). Conventional methods are either time-consuming or expensive when convenient extraction kits are used. Here we present an easy, but reliable extraction method that fulfills the requirements of epidemiological research (high sample throughput with maximum accuracy). A further advantage of the protocol beside the low costs is the absence of harmful chemicals like phenol or chloroform and the possibility to manage 'high-throughput' extractions and analyses.
description: VITIS - Journal of Grapevine Research, Vol. 59 No. 1 (2020): Vitis
Root transcriptome reveals responses to plastic film mulching and grass cover in wine grape 'Cabernet Sauvignon' root and berry
Creators: name: Wang, Rui
name: Sun, Quan
name: Xing, Xu
Publisher: name: VITIS - Journal of Grapevine Research
Year: 2020

description: This study was designed to investigate the influence of grass and film mulching on grape (V. vinifera) fruit quality and root transcriptome. The groundcovers (plastic film and seeds of herba portulacae and E. humifusa Willd) were set or sawn on the ground under wine grape plants ('Cabernet Sauvignon'). Test plots in the control group were treated with clean tillage. Properties of plant biochemicals under covers and grape berry quality were determined after two years. RNA-seq was analyzed for grape roots under different treatments. E. humifusa Willd cover increased plant total N and P; and film mulching increased plant total P and decreased plant total K. Herba portulacae cover decreased berry tannin and increased anthocyanin, soluble solid and titratable acid; E. humifusa Willd cover increased anthocyanin, soluble solid and titratable acid. Film mulching increased the contents of berry total phenols, soluble solid, and decreased titratable acid significantly in comparison with clean tillage. Root RNA-seq showed that there were 1, 0, and 42 differently expressed genes (DEGs) in Herba portulacae, E. humifusa Willd and film cover, compared with clean tillage, respectively. Film mulching increased the expression of root high-affinity nitrate transporter 2.1 (NRT2.1), NRT2.4 and glutamine synthetase, which associated with 'Nitrogen metabolism', and decreased the expression of root small class I/II heat shock proteins. Plastic film mulching increased grapple quality properties via activating N metabolism. Film mulching was a more excellent mulching for improving grape quality than grass cover in Ningxia, China.
description: VITIS - Journal of Grapevine Research, Vol. 59 No. 1 (2020): Vitis
Estimation of grapevine predawn leaf water potential based on hyperspectral reflectance data in Douro wine region
Creators: name: Tosin, R.
name: Pôças, I.
name: Gonçalves, I.
name: Cunha, M.
Publisher: name: VITIS - Journal of Grapevine Research
Year: 2020

description: Hyperspectral data collected through a handheld spectroradiometer (400-1010 nm) were tested for assessing the grapevine predawn leaf water potential (ѱpd) measured by a Scholander chamber in two test sites of Douro wine region. The study was implemented in 2017, being a year with very hot and dry summer, conditions prone to severe water shortage. Three grapevine cultivars, 'Touriga Nacional', 'Touriga Franca' and 'Tinta Barroca' were sampled both in rainfed and irrigated vineyards, with a total of 325 plants assessed in four post-flowering dates. A large set of vegetation indices computed with the hyperspectral data and optimized for the ѱpd values, as well as structural variables, were used as predictors in the model. From a total of 631 possible predictors, four variables were selected based on a stepwise forward procedure and the Wald statistics: irrigation treatment, test site, Anthocyanin Reflectance Index Optimized (ARIopt_656,647) and Normalized Ratio Index (NRI711,700). An ordinal logistic regression model was calibrated using 70 % of the dataset randomly selected and the 30 of the remaining observations where used in model validation. The overall model accuracy obtained with the validation dataset was 73.2 %, with the class of ѱpd corresponding to the high-water deficit presenting a positive prediction value of 79.3 %. The accuracy and operability of this predictive model indicates good perspectives for its use in the monitoring of grapevine water status, and to support the irrigation tasks.
description: VITIS - Journal of Grapevine Research, Vol. 59 No. 1 (2020): Vitis
Analysis of mechanics of side impact test defined in UN/ECE Regulation 129
Creators: name: Baranowski, Pawel
name: Damaziak, Krzysztof
name: Lukasz Mazurkiewicz
name: Malachowski, Jerzy
name: Muszynski, Artur
name: Vangi, Dario
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Objective: This article discusses differences between a side impact procedure described in United Nations/Economic Commission for Europe (UN/ECE) Regulation 129 and scenarios observed in real-world cases. Methods: Numerical simulations of side impact tests utilizing different boundary conditions are used to compare the severity of the Regulation 129 test and the other tests with different kinematics of child restraint systems (CRSs). In the simulations, the authors use a validated finite element (FE) model of real-world CRSs together with a fully deformable numerical model of the Q3 anthropomorphic test device (ATD) by Humanetics Innovative Solution, Inc. Results: The comparison of 5 selected cases is based on the head injury criterion (HIC) index. Numerical investigations reveal that the presence of oblique velocity components or the way in which the CRS is mounted to the test bench seat fixture is among the significant factors influencing ATD kinematics. The results of analyses show that the side impact test procedure is very sensitive to these parameters. A side impact setup defined in Regulation 129 may minimize the effects of the impact. Conclusions: It is demonstrated that an artificial anchorage in the Regulation 129 test does not account for a rotation of the CRS, which should appear in the case of a realistic anchorage. Therefore, the adopted procedure generates the smallest HIC value, which is at the level of the far-side impact scenario where there are no obstacles. It is also shown that the presence of nonlateral acceleration components challenges the quality of a CRS and its headrest much more than a pure lateral setup.
Molecular biology and evolution of cancer: from discovery to action.
Creators: name: Somarelli, Jason A
name: Gardner, Heather
name: Cannataro, Vincent L
name: Gunady, Ella F
name: Boddy, Amy M
name: Johnson, Norman A
name: J Nicholas Fisk
name: Gaffney, Stephen G
name: Chuang, Jeffrey H
name: Li, Sheng
name: Ciccarelli, Francesca D
name: Panchenko, Anna R
name: Megquier, Kate
name: Kumar, Sudhir
name: Dornburg, Alex
name: DeGregori, James
name: Townsend, Jeffrey P
Publisher: name: The Francis Crick Institute
Year: 2020
Subjects: Genetics & Genomics
Genome Integrity & Repair
Gene Expression
Computational & Systems Biology

description: The progression of cancer is an evolutionary process. During this process, evolving populations of cancer cells encounter restrictive ecological niches within the body, such as the primary tumor, the circulatory system, and diverse metastatic sites. Heterogeneous populations of cancer cells undergo selection for adaptive phenotypes, which shapes molecular genetic variation amid concomitant genetic drift. Cell lineages undergo convergent evolution toward phenotypes known as the hallmarks of cancer that promote cancer initiation, growth, and metastasis. Efforts to prevent or delay cancer evolution-and progression-require a deep understanding of the underlying molecular evolutionary processes. Herein we discuss a suite of concepts and tools from evolutionary and ecological theory that can inform-and possibly transform-cancer biology in new and meaningful ways. These concepts and tools include comparative research on cancer across diverse species and application of phylogenetic approaches to analyze the evolution of tumor progression and metastasis. Fitness landscapes can be leveraged to describe potential trajectories of cancer evolution, mapping positive selection and neutral evolution of proto-oncogenes, tumor suppressors, and other functional elements. We also highlight current challenges to applying these concepts and propose research areas that, by incorporating these concepts, could identify new therapeutic modes and vulnerabilities in cancer.
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Cart. 188 (11 H 73), f. 0208r
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Archives départementales de la Côte-d'Or, Cart. 188 (11 H 73), f. 0208r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Archives départementales de la Côte-d'Or, Cart. 188 (11 H 73), f. 0208r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
title: Carolina Beach State Park Pier Repairs
title: Endangered Species Act - Section 7 Biological Opinion Carolina Beach State Park Fishing Pier Demolition and Replacement
Creators: name: United States. National Marine Fisheries Service. Southeast Region
Publisher: name: United States. National Marine Fisheries Service. Southeast Region
Year: 2022

description: ESA Section 7 Consultation ; SERO-2021-01529
THE PRIVATE MANAGEMENT OF NOTARY AND REGISTRATIVE ACTIVITIES AND THE REFLECTIONS IN THE MANDATORY SPHERE: AN ANALYSIS FROM THE CONCENTRATED CONTROL OF CONSTITUTIONALITY
Creators: name: FRANCISCO CARDOZO OLIVEIRA
name: VERONICA POFFO TISCOSKI
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: The purpose of this article is to analyze the main consequences of the private management of notary and registration activities in the obligatory sphere. Through the analysis of direct actions of unconstitutionality, it was sought to verify which are the main elements discussed, to understand the fundamentals of each decision and to draw up a standardization of the legal nature applicable to the notarial and registry activity. By the qualitative and quantitative methods it was possible to reach the conclusion that it is a sui generis activity, whose own regime requires a more detailed analysis by those who dedicate themselves to it.
Control Strategy in Movements with Transmission Delay
Creators: name: Hoffmann, Errol R.
name: Karri, Shilpa
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The strategy used by participants was studied when making movements in a Fitts movement paradigm with transmission delay between control input and display output. Fitts' law in the modified form developed by E. R. Hoffmann (1992) gave an excellent description of the data. Movement time could also be expressed as a function of the total delay time (number of submovements × transmission delay) and Fitts' index of difficulty (ID). Two types of submovement were identified, being step and drag forms. The number of step submovements was the most important in determining movement time. These were related to a move-and-wait strategy used by participants. Number of submovements increased with the level of ID and transmission delay and was linearly related to the ID and product of ID by transmission delay.
title: Ritchey Creek Bridge Replacement
title: Endangered Species Act Section 7(a)(2) Biological Opinion and Magnuson-Stevens Fishery Conservation and Management Act Essential Fish Habitat Response for the Ritchey Creek Bridge Replacement Project near the City of Calistoga in Napa County, California (EA 04-4J990)
Creators: name: United States. National Marine Fisheries Service. West Coast Region
Publisher: name: United States. National Marine Fisheries Service. West Coast Region
Year: 2022

description: ESA Section 7 Consultation ; WCRO-2021-00706
Additional file 1 of Association between Impella device support and elevated rates of gout flares: a retrospective propensity-matched study
Creators: name: Sinclair De Frías, Jorge
name: Isha, Shahin
name: Olivero, Lorenzo
name: Raavi, Lekhya
name: Narra, Sai Abhishek
name: Paghdar, Smit
name: Jonna, Sadhana
name: Satashia, Parthkumar
name: Hannon, Rachel
name: Blasavage, Jessica
name: White, Layton
name: Olanipekun, Titilope
name: Bansal, Pankaj
name: Kiley, Sean
name: Leoni, Juan Carlos
name: Nativí, Jose
name: Lyle, Melissa
name: Thomas, Mathew
name: Sareyyupoglu, Basar
name: Pham, Si
name: Smith, Michael
name: Moreno Franco, Pablo
name: Patel, Parag
name: Sanghavi, Devang
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Cancer
subject: Science Policy

description: Supplementary Material 1
ANALYSIS OF ACCOUNTING DEVELOPMENTS AS AN AUXILIARY TOOL FOR DECISION MAKING OF STAKEHOLDERS: STUDY IN AGRIBUSINESS COMPANIES
Creators: name: JANDESON DANTAS DA SILVA
name: WÊNYKA PRESTON LEITE BATISTA DA COSTA
name: LAILSON DA SILVA REBOUÇAS
name: ERIKA MAIA DA ROCHA
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: Agribusiness in Brazil has a significant participation in the economy of the country, for example, not 2016 GDP was 23% with a prospect of expansion of 2% to 2017. In 2016 the sector accounted for 45.9% of the country's total exports. The research is justified by the need to generate information that helps decision-making by stakeholders, including shareholders, government, employees, society, suppliers, financiers and clients. Constitution the research problem: Which entities involved better performance among the public or private capital of the agribusiness, in terms of liquidity, indebtedness, profitability, return and EBITDA? Forming the following objective, identify a performance of open and closed entities in the agribusiness sector related to the liquidity, indebtedness, profitability, return and EBITDA indices. The methodology used to obtain the statements of the companies of this branch of publicly traded on BM & FBOVESPA and do not refer to privately held companies were searched entities operating in Rio Grande do Norte - RN. It is based on a quantitative case study with the use of descriptive statistics techniques, it is emphasized that the data period will be from 2014 to 2015. The findings show that, in relation to the private entity, The highest indexes and no increase in the composition of indebtedness, as capital companies represent their indices in constant changes, both positively and negatively.
title: Alpine Road Undercrossing Bridge Seismic Restoration Project
title: Endangered Species Act Section 7(a)(2) Biological for the Alpine Road Undercrossing Bridge Seismic Restoration Project
Creators: name: United States. National Marine Fisheries Service. West Coast Region
Publisher: name: United States. National Marine Fisheries Service. West Coast Region
Year: 2022

description: ESA Section 7 Consultation ; WCRO-2021-02652
title: Ricelands Juvenile Salmonid Rearing Project
title: Endangered Species Act Section 7(a)(2) Biological Opinion and Magnuson-Stevens Fishery Conservation and Management Act Essential Fish Habitat Response for the Ricelands Juvenile Salmonid Rearing Technical Guidelines and Management Activity Specifications Research Project
Creators: name: United States. National Marine Fisheries Service. West Coast Region
Publisher: name: United States. National Marine Fisheries Service. West Coast Region
Year: 2022

description: ESA Section 7 Consultation ; WCRO-2021-02725
title: Joint Lower Alameda Creek Fish Passage Improvements Project
title: Endangered Species Act Section 7(a)(2) Biological Opinion and Magnuson-Stevens Fishery Conservation and Management Act Essential Fish Habitat Response for the Joint Lower Alameda Creek Fish Passage Improvements Project in Fremont, California (Corps File No. 2013-00083S)
Creators: name: United States. National Marine Fisheries Service. West Coast Region
Publisher: name: United States. National Marine Fisheries Service. West Coast Region
Year: 2017

description: ESA Section 7 Consultation ; WCRO-2013-00025
ETHICS AND THE MULTI-DIMENSIONAL SOCIAL FUNCTION IN BUSINESS ORGANIZATIONS
Creators: name: SALIM REIS DE SOUZA
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: Based on the assumption that ethics is based, essentially, on the respect of the human person. Do these technologies, associated with the maximization of the negotiating efficiency of the so-called Integrated Markets, respect the human person as the ultimate recipient of the rights that originate from the creation of these markets? Is there not the risk of reducing the human being to a mere object of manipulation in the famous quest for efficiency and the total quality of the business world? Does being a bearer of greater knowledge today lead man to recognize his duty to his neighbor, to society and to the environment in which he lives? These questions need to be solved and analyzed in the light of ethics, morality and Fundamental Rights of the Human Person. These are questions that concern all people and the community at large; but particularly to sociologists, psychologists, journalists, philosophers, theologians and also jurists; who today need to dialogue, in an interdisciplinary attitude, with the following objective: to put technological progress and the set of regulatory norms of the business world at the service of human life; of the dignity of the human person as supreme values of all kinds of harmony and social coexistence. From this, the present article concludes that it can not be forgotten that man was not made for society or for the State. It is society that is made for the human person, and plays.
title: EPA NPDES permit reissuance for the Point Loma Wastewater Treatment Plant and Ocean Outfall
title: Endangered Species Act (ESA) Section 7(a)(2) Biological opinion and Magnuson-Stevens Fishery Conservation and Management Act Essential Fish Habitat (EFH) Consultation National Marine Fisheries Service (NMFS) Evaluation of Hatchery and Genetic Management Plans for Hood Canal Salmon under Limit 6 of the Endangered Species Act Section 4(d) Rule (Reinitiation 2021)
Creators: name: United States. National Marine Fisheries Service. West Coast Region
Publisher: name: United States. National Marine Fisheries Service. West Coast Region
Year: 2022

description: ESA Section 7 Consultation ; WCRO-2021-03010
ANALYSIS OF FACTORS DETERMINING DEVELOPMENTS IN MANAUS MUNICIPAL DEBT IN THE PERIOD 2010 TO 2015
Creators: name: ANDRÉ RICARDO REIS COSTA
name: JOÃO TIAGO SOUZA DE ARAÚJO
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: The LRF outlines budgetary control mechanisms to curb public deficits. However, the effectiveness of the LRF depends on the period and the sample used, since the standardized limits are not always in agreement with the reality of the municipalities. The municipality of Manaus obeyed the limits defined by the LRF, being well below in most cases. Current intergovernmental transfers accounted for around 60% of Total Revenue and 70% of the current revenue group, while capital transfers ranged from 0.5% in 2013 to 1,374 in 2012. The most relevant group in the composition of Revenue is Current Revenues. Current Transfers provide a greater range of resources within the group, expressing dependence on Intergovernmental Transfers. The Municipality has a satisfactory equity situation where the Deposits cover Current Liabilities and Assets is sufficient to pay the Liabilities. There was a tendency to contract long-term liabilities, so Current Liabilities accounted for approximately 50% in 2010, increased to 13% in 2015. Asset gains were greater than losses or devaluations. There was frustration in the collection in 2012, 2013, 2014 and 2015, which was offset by the budget execution, with the exception of 2015.
title: The 2021 longline survey of the Gulf of Alaska and eastern Bering Sea on the FV Alaskan Leader: Cruise Report AL-21-01
Creators: name: Siwicke, K.
Publisher: name: Alaska Fisheries Science Center (U.S.) Auke Bay Laboratories (Juneau, Alaska)
Year: 2022

description: AFSC processed report ; 2022-01
Analysis of Mechanics of Side Impact Test Defined in UN/ECE Regulation 129
Creators: name: Baranowski, Pawel
name: Damaziak, Krzysztof
name: Lukasz Mazurkiewicz
name: Malachowski, Jerzy
name: Muszynski, Artur
name: Vangi, Dario
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy

description: Objective: This article discusses differences between a side impact procedure described in UN/ECE Regulation 129 and scenarios observed in real world cases. Methods: Numerical simulations of side impact tests utilizing different boundary conditions are used to compare the severity of the Regulation 129 test and the other tests with different kinematics of child resistant systems (CRS). In the simulations, the authors use a validated finite element (FE) model of real world CRS together with a fully deformable numerical model of the Q3 anthropomorphic test device (ATD) by Humanetics Innovative Solution, Inc. Results: The comparison of five selected cases is based on the head injury criterion (HIC) index. Numerical investigations reveal that the presence of oblique velocity components or the way in which the CRS is mounted to the test bench seat fixture is among the significant factors influencing ATD kinematics. The results of analyses show that the side impact test procedure is very sensitive to these parameters. A side impact setup defined in Regulation 129 may minimize the effects of the impact. Conclusions: It is demonstrated that an artificial anchorage in the Regulation 129 test does not account for a rotation of the CRS, which should appear in the case of a realistic anchorage. Therefore, the adopted procedure generates the smallest HIC value, which is at the level of the far side impact scenario where there are no obstacles. It is also shown that the presence of non-lateral acceleration components challenges the quality of a CRS and its headrest much more than a pure lateral set-up.
SIMPLE NATIONAL: A MEANS FOR COMPLIANCE WITH THE COMPANY'S SOCIAL FUNCTION
Creators: name: CELINA YAMAO
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: In 2007, after a revocation of other less comprehensive versions, the Simples Nacional appeared, a unified tax system with the promise of simplifying a taxpayer life, reducing the amount of taxes that the entrepreneur must collect to the public coffers. Thus, this article will deal with the functioning of the system and what impacts it can bring to a company and to society. Through a specific bibliographical research in this area, the union of forces between the State and private to be fulfilled as functions, in a great virtuous circle where everybody wins, entrepreneur, government and society, is concluded, because, the more all of them Work in search of common good and social responsibility, there will be more equalities and freedoms and consequently less injustice.
MEDIATION OF ARBITRATION AND CONCILIATION FOR THE RESOLUTION OF BUSINESS CONFLICTS
Creators: name: MIGUEL KFOURI NETO
name: ANDRE FATUCH NETO
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: This article seeks to identify how mediation and arbitration can help resolve corporate conflicts in Brazil and Mercosur, following the innovations brought by the Brazilian Code of Civil Procedure of 2015, emphasizing the importance for the development of arbitration in the Brazilian legal system. A historical approach was made, pointing out the necessary requirements and the difficulties encountered, whether due to the diversity of foreign systems or ideological legal reasons. The characteristics inherent to mediation, arbitration and conciliation in the three different systems will be analyzed, among others, in order to identify the treatment of alternative means of conflict resolution by Brazilian legal systems, their breadth and complexity. Its consequences and its importance.
STRATEGIC PLANNING AS A TOOL: A STUDY ON THE EFFICIENCY OF MICRO AND SMALL BRAZILIAN COMPANIES
Creators: name: SANDRO AUGUSTO TEIXEIRA DE MENDONÇA
name: ANA PAULA DE ALMEIDA RUZZÃO
name: JÉSSICA EMILY DOS SANTOS
name: LILIANE ZUIM AZADINHO
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: Micro and small companies are increasingly present along with the growth of the Brazilian economy. For these companies to remain and establish themselves in the market became necessary to use the strategic tools. This paper discussed the needs of strategic planning and organizational forms, identifying the important tools for the manager. It presents the mishaps of the importance of the application of the strategic planning by the manager, lack of knowledge of this one and how it implies in the mortality rate of the small business. Through the bibliographic research it was verified that the lack of application of the strategic planning, knowledge of the entrepreneur and the management in the micro and small companies are factors that involve in the increase of the rate of mortality of the companies.
OF THE WORK OF PEOPLE WITH DISABILITIES: NOTHING ABOUT US, WITHOUT US
Creators: name: MARIA LÚCIA DE BARROS RODRIGUES
name: ROSELIA FURMAN CARNEIRO DA SILVA
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: According to the UN, there are currently around one billion people with disabilities worldwide, of whom 25 million live in Brazil, according to the WHO. Being the "largest minority" in the world, this group of people deserves a more attentive and inclusive look. The famous motto "nothing about us, without us", adopted worldwide since the 80s, brings in its essence the ideal of full participation of people with disabilities in all decisions related to them. The motto conveys the idea that no policy should be decided by any representative without the full and direct participation of the members of the group affected by that policy. In this sense, the present bibliographical study of doctrinal and legislative basis, under the deductivequantitative method, has the objective of exposing the reflection that it is necessary for all to understand that this human being is not a victim, not a hero, is only different, because The society is deficient, that is, it was not created by / for people with disabilities, which limits many actions, despite the qualification and aptitude. On the horizon of these assumptions, it is clear that the intersection of vulnerabilities must be observed by public policies, since productive employment and decent work are key elements for achieving a fair globalization with reduction of architectural and attitudinal barriers that have not yet been overcome Only with the edition of legal norms. It is the moral norms that must be "reissued".
Additional file 1 of Flexible bronchoscopy insufflated and high-flow nasal oxygen pilot trial (BUFFALO protocol pilot trial)
Creators: name: Humphreys, Susan
name: Schibler, Andreas
name: Williams, Tara
name: Spall, Susan
name: Pham, Trang
name: Atkins, Tiffany
name: Goyal, Vikas
name: Sommerfield, David
name: Sommerfield, Aine
name: Keys, Adam
name: Hauser, Neil
name: von Ungern-Sternberg, Britta S
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Appendices.
АГРОТЕХНИКА НОВЫХ СОРТОВ И ГИБРИДОВ МАРКОВИ В УСЛОВИЯХ ФЕРГАНСКОЙ ДОЛИНЫ УЗБЕКИСТАНА
Creators: name: Мирахмедов, Ф.Ш.
name: Саксонбоева, М.Л.
name: Маннапова, У.А.
Publisher: name: Zenodo
Year: 2024

description: В статье представлена хозяйственно-биологическая характеристика новых сортов моркови созданных для возделывания в условиях ферганской долины Узбекистана. Подробно дано описание новых сортов, обобщены результаты научно-исследовательской работы с новыми сортами за 2022-2023 годы проведенные в Андижанском институте сельского хозяйства и агротехнологий.
title: ADCO, Ordre cistercien : comptes (1499-1515) (11 H 1162), f. 00094
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: comptes
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Ordre cistercien : comptes (1499-1515), Archives départementales de la Côte-d'Or, (11 H 1162). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Ordre cistercien : comptes (1499-1515), Archives départementales de la Côte-d'Or, (11 H 1162), f. 00094, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Additional file 1 of Consequences of heterogeneity in aging: parental age at death predicts midlife all-cause mortality and hospitalization in a Swedish national birth cohort
Creators: name: Thalén, Anna
name: Ledberg, Anders
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: Cancer
subject: Computational Biology

description: Additional file 1: Figure S1. Description of the study sample selection. Figure S2. Cumulative hazards of index persons’ all-cause mortality, stratified by parental attained age based on chronological age (n= 89 688). Figure S3. Cumulative hazards of index persons’ hospitalizations, stratified by parental attained age based on chronological age (n= 89 688). Figure S4. Cumulative hazards of index persons’ all-cause mortality, stratified by quartiles of average parental attained age where the lower threshold for parental age at death was set to 65. (N= 75274). Figure S5. Cumulative hazards of index persons’ hospitalizations, stratified by quartiles of average parental attained age where the lower threshold for parental age at death was set to 65. (N= 75274). Figure S6. Cumulative hazards of index persons’ all-cause mortality, stratified by quartiles of maternal and paternal attained age on the total population (n= 89 688). Figure S7. Cumulative hazards of index persons’ hospitalizations, stratified by quartiles of paternal attained age on the total population (n= 89688). Figure S8. Cumulative hazards of index persons’ hospitalizations, stratified by quartiles of maternal attained age on the total population (n= 89688). Figure S9. Hazard rate ratios for stratified regression models using paternal and maternal attained age as exposure variable. Figure S10. Cumulative hazards of index persons’ hospitalizations, stratified by quartiles of parents attained age, men (n= 46048). Figure S11. Cumulative hazards of index persons’ hospitalizations, stratified by quartiles of parents attained age, women (n= 43640).
Madrid, Biblioteca Nacional de España, R/12531, fol. 29v-33v, transcription diplomatique (Gregorius Digital E1-1)
Creators: name: Andersen, Peter
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2025

description: Ce document Word est une transcription diplomatique de l'exemplaire Madrid, Biblioteca Nacional de España, R/12531, fol. 29v-33v, de l’édition espagnole « El Patrañuelo », Valence, Juan Mey, 1567, contient le récit du Bon Pécheur et est édité dans le cadre du projet Gregorius Digital sous le sigle E1-1 (dir. Peter Andersen – ARCHE UMR 3400 – Université de Strasbourg)
Research Hypothesis
Creators: name: Rombouts, Vicky A.
name: Foote, Jeff
name: Berg, Nathan
Publisher: name: OSF Registries
Year: 2025

description: The research examines the causal relationship between Information Providing Agent’s (IPA) motivation, including incentives, attitudes and or pressure and the behaviour to tailor, refine, modify or shape investment proposal information. Both the Theory of Planned behaviour and Agency Theory serve as a platform for evaluating how motivational factors influence the likelihood of performing or engaging in such behaviour.
SKILLS DEFINED IN THE NATIONAL CURRICULAR GUIDELINES OF THE GRADUATION COURSE IN ADMINISTRATION, BACHELOR: ARE THERE DIFFICULTIES OF EVALUATION AND CERTIFICATION IN THE DAY-TO-DAY PRACTICE IN A CLASSROOM?
Creators: name: SILAS BORGES MONTEIRO
name: SANDRA STÖCKLI ARANTES
Publisher: name: figshare
Year: 2017
Subjects: subject: Law
subject: FOS: Law

description: For the study, we opted for the case study method. Data analysis for verification and analysis through research in higher education institutions that offer undergraduate degree in Business Administration, if it occurs reviews and skills certifications, with special emphasis defined in the national curriculum guidelines. The aim of the study was defined as follows: Check the way they are contemplate the skills and provided skills in the National Curriculum Guidelines for Course Administration, Bachelor in PPC - Educational Project Course and in the syllabus of courses, its conceptual definition, and form for evaluation and measuring them in practice day to day in the classroom. The study included the following problem: From the creation of the Curriculum Management Course National Guidelines, bachelor's degree, which requires higher education institutions to fulfill it, with special emphasis on the great skills and abilities that enable minimally training required for an Administrator, evaluations and certifications of them are practiced in fact? As a result, it was found that the objective was achieved, however, the problem defined in the study, despite the practice adopted for the course, was not answered conclusively, by the limitations of the surveyed performed, it is not possible to understand the evaluations They are successful and consequently proves to certification of competencies defined within the framework of national curriculum guidelines.