title: ÐÑÐµÐ½ÐºÐ° ÑÐ¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸Ñ Ð¼Ð°Ð»Ð¾Ð½Ð¾Ð²Ð¾Ð³Ð¾ Ð´Ð¸Ð°Ð»ÑÐ´ÐµÐ³Ð¸Ð´Ð° Ð¸ Ð²Ð¾ÑÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð³Ð»ÑÑÐ°ÑÐ¸Ð¾Ð½Ð° Ð² ÑÐºÐ°Ð½ÑÑ Ð¿ÐµÑÐµÐ½Ð¸ Ð¸ Ð³Ð¾Ð»Ð¾Ð²Ð½Ð¾Ð³Ð¾ Ð¼Ð¾Ð·Ð³Ð° Ñ Ð¼ÑÑÐµÐ¹ Ñ Ð¸Ð½ÑÑÐ°ÐºÑÐ°Ð½Ð¸Ð°Ð»ÑÐ½ÑÐ¼Ð¸ Ð¾Ð¿ÑÑ Ð¾Ð»ÑÐ¼Ð¸ Ð¿ÑÐ¸ Ð»ÐµÑÐµÐ½Ð¸Ð¸ Ð»Ð¾Ð¼ÑÑÑÐ¸Ð½Ð¾Ð¼
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Assessment of the content of malondialdehyde and reduced glutathione in liver and brain tissues in mice with intracranial tumors during treatment with lomustine
Creators: name: ÐÐ°ÑÐºÐ°ÑÐ¾Ð²Ð°, ÐÐ»Ð¸Ð·Ð°Ð²ÐµÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: Ð»Ð¸Ð¼ÑÐ¾ÑÐ°ÑÐºÐ¾Ð¼Ð°
Ð»Ð¾Ð¼ÑÑÑÐ¸Ð½
Ð½ÐµÐ²ÑÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÑÐ°ÑÑÑ
Ð¼Ð°Ð»Ð¾Ð½Ð¾Ð²ÑÐ¹ Ð´Ð¸Ð°Ð»ÑÐ´ÐµÐ³Ð¸Ð´
Ð²Ð¾ÑÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð½ÑÐ¹ Ð³Ð»ÑÑÐ°ÑÐ¸Ð¾Ð½
lymphosarcoma
lomustin
neurological status
malondialdehyde
reduced glutathione

description: Ð¦ÐµÐ»Ñ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ â Ð¸Ð·ÑÑÐ¸ÑÑ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ ÑÐ¸Ð¼Ð¸Ð¾Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ° Ð»Ð¾Ð¼ÑÑÑÐ¸Ð½ Ð½Ð° ÑÐ¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸Ðµ Ð¼Ð°Ð»Ð¾Ð½Ð¾Ð²Ð¾Ð³Ð¾ Ð´Ð¸Ð°Ð»ÑÐ´ÐµÐ³Ð¸Ð´Ð° (Ð¼Ð°ÑÐºÐµÑ Ð¾ÐºÑÐ¸Ð´Ð°ÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ ÑÑÑÐµÑÑÐ°) Ð¸ Ð²Ð¾ÑÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð³Ð»ÑÑÐ°ÑÐ¸Ð¾Ð½Ð° (Ð¼Ð°ÑÐºÐµÑ Ð°Ð½ÑÐ¸Ð¾ÐºÑÐ¸Ð´Ð°Ð½ÑÐ½Ð¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ Ð·Ð°ÑÐ¸ÑÑ) Ð² ÑÐºÐ°Ð½ÑÑ Ð¿ÐµÑÐµÐ½Ð¸ Ð¸ Ð³Ð¾Ð»Ð¾Ð²Ð½Ð¾Ð³Ð¾ Ð¼Ð¾Ð·Ð³Ð° Ñ Ð¼ÑÑÐµÐ¹ Ñ ÑÑÐ°Ð½ÑÐ¿Ð»Ð°Ð½ÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð¹ Ð¸Ð½ÑÑÐ°ÐºÑÐ°Ð½Ð¸Ð°Ð»ÑÐ½Ð¾ Ð»Ð¸Ð¼ÑÐ¾ÑÐ°ÑÐºÐ¾Ð¼Ð¾Ð¹ ÐÐÐ-1. Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð½Ð°ÑÑÐ½Ð¾-Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°ÑÐµÐ»ÑÑÐºÐ¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ ÑÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð¾, ÑÑÐ¾ Ð»Ð¾Ð¼ÑÑÑÐ¸Ð½ Ð¾Ð±Ð»Ð°Ð´Ð°ÐµÑ Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð¾Ð¿ÑÑÐ¾Ð»ÐµÐ²Ð¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑÑ Ñ Ð¼ÑÑÐµÐ¹ Ð»Ð¸Ð½Ð¸Ð¸ BALÐ/Ñ Ñ ÑÑÐ°Ð½ÑÐ¿Ð»Ð°Ð½ÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð¹ Ð¸Ð½ÑÑÐ°ÐºÑÐ°Ð½Ð¸Ð°Ð»ÑÐ½Ð¾ Ð»Ð¸Ð¼ÑÐ¾ÑÐ°ÑÐºÐ¾Ð¼Ð¾Ð¹ ÐÐÐ-1, ÑÐ¾Ð³Ð»Ð°ÑÐ½Ð¾ Ð½ÐµÐ²ÑÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ð¼ Ð¸ Ð±Ð¸Ð¾ÑÐ¸Ð¼Ð¸ÑÐµÑÐºÐ¸Ð¼ Ð¿Ð¾ÐºÐ°Ð·Ð°ÑÐµÐ»ÑÐ¼ Ð½Ð°Ð¸Ð±Ð¾Ð»ÐµÐµ Ð²ÑÑÐ°Ð¶ÐµÐ½Ð¾ ÑÐµÑÐ°Ð¿ÐµÐ²ÑÐ¸ÑÐµÑÐºÐ¾Ðµ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ Ð»Ð¾Ð¼ÑÑÑÐ¸Ð½Ð° Ð½Ð° 7 ÑÑÑÐºÐ¸ Ð¿Ð¾ÑÐ»Ðµ ÑÑÐ°Ð½ÑÐ¿Ð»Ð°Ð½ÑÐ°ÑÐ¸Ð¸ Ð¾Ð¿ÑÑÐ¾Ð»Ð¸. ÐÐ°Ð½Ð½ÑÐµ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐ¾Ð² Ð½ÐµÐ²ÑÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ ÑÐµÑÑÐ¾Ð² Ð¿Ð¾ Ð¾ÑÐµÐ½ÐºÐµ ÑÐ¾ÑÑÐ¾ÑÐ½Ð¸Ñ Ð½ÐµÑÐ²Ð½Ð¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÑ Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÑ Ð¸ Ð±Ð¸Ð¾ÑÐ¸Ð¼Ð¸ÑÐµÑÐºÐ¸Ð¼Ð¸ Ð¼Ð°ÑÐºÐµÑÐ°Ð¼Ð¸ Ð¾ÐºÑÐ¸Ð´Ð°ÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ ÑÑÑÐµÑÑÐ° (Ð¼Ð°Ð»Ð¾Ð½Ð¾Ð²ÑÐ¹ Ð´Ð¸Ð°Ð»ÑÐ´ÐµÐ³Ð¸Ð´) Ð¸ Ð°Ð½ÑÐ¸Ð¾ÐºÑÐ¸Ð´Ð°Ð½ÑÐ½Ð¾Ð¹ Ð·Ð°ÑÐ¸ÑÑ (Ð²Ð¾ÑÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð½ÑÐ¹ Ð³Ð»ÑÑÐ°ÑÐ¸Ð¾Ð½) ÐºÐ»ÐµÑÐ¾Ðº ÑÐºÐ°Ð½ÐµÐ¹ Ð³Ð¾Ð»Ð¾Ð²Ð½Ð¾Ð³Ð¾ Ð¼Ð¾Ð·Ð³Ð° Ð¸ Ð¿ÐµÑÐµÐ½Ð¸ Ð¿Ð¾ÐºÐ°Ð·ÑÐ²Ð°ÑÑ Ð·Ð°ÐºÐ¾Ð½Ð¾Ð¼ÐµÑÐ½Ð¾ÑÑÑ ÐºÐ°Ðº Ð½Ð° ÑÐ¾Ð½Ðµ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ Ð¾Ð¿ÑÑÐ¾Ð»Ð¸, ÑÐ°Ðº Ð¸ Ð¿ÑÐ¸ Ð»ÐµÑÐµÐ½Ð¸Ð¸ Ð»Ð¾Ð¼ÑÑÑÐ¸Ð½Ð¾Ð¼. Ð ÐµÐºÐ¾Ð¼ÐµÐ½Ð´Ð¾Ð²Ð°Ð½Ð¾ Ð¿ÑÐ¾Ð´Ð¾Ð»Ð¶ÐµÐ½Ð¸Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¹ Ð¿Ð¾ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ ÑÐ¾Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸ÑÐµÐ»ÑÐ½Ð¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸ Ð½Ð° Ð¼Ð¾Ð´ÐµÐ»ÑÑ Ð¸Ð½ÑÑÐ°ÐºÑÐ°Ð½Ð¸Ð°Ð»ÑÐ½ÑÑ Ð¾Ð¿ÑÑÐ¾Ð»ÐµÐ¹, ÐºÐ¾ÑÐ¾ÑÐ°Ñ Ð¾Ð±Ð»Ð°Ð´Ð°ÐµÑ Ð°Ð½ÑÐ¸Ð¾ÐºÑÐ¸Ð´Ð°Ð½ÑÐ½ÑÐ¼Ð¸ ÑÐ²Ð¾Ð¹ÑÑÐ²Ð°Ð¼Ð¸. ÐÑÐ¸ Ð²ÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð¸Ð¸ Ð»Ð¸ÑÐµÑÐ°ÑÑÑÐ½Ð¾Ð³Ð¾ Ð¾Ð±Ð·Ð¾ÑÐ° Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð»Ð¸ÑÑ ÑÐ»ÐµÐ´ÑÑÑÐ¸Ðµ Ð±Ð°Ð·Ñ Ð´Ð°Ð½Ð½ÑÑ eLIBRARY.RU, Elsevier ScienceDirect, Scopus, PubMed, PubChem, MDPI â Publisher of Open Access Journals, MDPI â Publisher of Open Access Journals, cyberleninka. Ð¡ÑÐ°ÑÐ¸ÑÑÐ¸ÑÐµÑÐºÑÑ Ð¾Ð±ÑÐ°Ð±Ð¾ÑÐºÑ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÑ Ð´Ð°Ð½Ð½ÑÑ Ð¾ÑÑÑÐµÑÑÐ²Ð»ÑÐ»Ð¸ Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð¿Ð°ÐºÐµÑÐ° Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼ Microsoft Excel, GraphPad Prism Ð²ÐµÑÑÐ¸Ð¸ 8.0, ÑÐ·ÑÐºÐ° Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Python 3.10.
description: The purpose of this research is to study the effect of the chemotherapy drug lomustin on the content of malondialdehyde (a marker of oxidative stress) and reduced glutathione (a marker of the antioxidant defense system) in liver and brain tissues in mice with transplanted intracranial lymphosarcoma LIO-1. As a result of research work, it was found that lomustin has antitumor activity in BALB/c mice with intracranially transplanted lymphosarcoma LIO-1, according to neurological and biochemical parameters, the therapeutic effect of lomustin is most pronounced on the 7th day after tumor transplantation. The data of the results of neurological tests to assess the state of the nervous system of experimental ani-mals and biochemical markers of oxidative stress (malondialdehyde) and antioxi-dant protection (reduced glutathione) of brain and liver tissue cells show regularity both against the background of tumor development and during treatment with lo-mustine. It is recommended to continue research on the use of concomitant therapy on models of intracranial tumors, which has antioxidant properties. The following databases were used to perform the literature review: eLi-brary.RU, Elsevier ScienceDirect, Scopus, PubMed, PubChem, MDPI â Publisher of Open Access Journals, MDPI â Publisher of Open Access Journals, cyberlenin-ka. Statistical processing of experimental data was carried out using the Microsoft Excel software package, GraphPad Prism version 8.0, and the Python 3.10 programming language.