cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Revised System Architecture
Creators: name: Francois Carrez
Publisher: name: Zenodo
Year: 2022

description: This revised architecture document is the second in a series of three incremental versions. It aims to give a revision and extension of the system architecture which consists of a set of architecture views and perspectives. We tackle here many aspects of the desired DEDICAT 6G architecture, especially functional and non-functional and provide an improved and more precise understanding of which functionalities the platform will provide and which qualities (in terms of performance, trust, reliability - to name just a few) this platform will feature. Before introducing the architecture, it is worth reminding the main technical objectives of DEDICAT 6G, that are the three following pillars: 1) dynamic coverage extension of existing legacy 5G Network, 2) dynamic intelligence distribution towards (mobile) edge nodes and 3) novel solutions for trust management based on federated learning. The architecture work follows a precise and logical methodology that encompasses various steps, starting from an extensive requirement engineering process including a few new requirements from D2.3 (included in the new Volere template), followed by a revised functional decomposition that gives a full catalog at the functionalities which must be specified and implemented in order to fulfill those project technical objectives and an updated description of the non-functional properties it must implement. Other steps involve defining the technical perimeter of the platform (what is in and what is out), elucidating the role of the external entities (human or not) and their interactions with the DEDICAT 6G system and most importantly, defining an extensive list of system use-cases (already introduced graphically and textually in the initial version) featuring precise sequence diagrams. The Network Deployment view includes now, in addition to the generic view provided in D2.2, a customized network deployment view for each of the four project Use Cases. Finally, the new Information view provides an extensive list of interfaces for most of the platform components with associated data models. Those interfaces are referred to, in the system use-case sequence diagrams. The perspective section has been extended with the Performance perspective, in order to complement the existing Privacy, Security and Trust ones. This second version of the architecture document will be complemented by a third and final iteration (D2.5), the main goal of which, will be to be fully aligned with WP3, 4 and 5 technical results. The overall planned improvements for D2.5 are listed in the conclusion section.
CURRENCY RISK MANAGEMENT AT COMPANIES OF AGRO-INDUSTRIAL COMPLEX
Creators: name: Yu. Yu. Platonova
name: T. N. Bondarenko
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: risks
currency risks
assessment tools
risk hedging
management optimization

description: This article examines the economic relations arising in the process of managing and minimizing currency risks. There was presented a comprehensive classification of currency risks and systematic methods of managing them. The commodity structure of Russian exports was analyzed and there was determined the current state of Russian exports of agricultural products. Moreover, based on the study and analysis of foreign and Russian experience in currency risk management, proposals were developed for comprehensive optimization of hedging methods and currency risk management on the example of an export-oriented enterprise in the field of agriculture.
An overview of clinical and commercial impact of drug delivery systems
Creators: name: Anselmo, A.C.
name: Mitragotri, S.
Publisher: name: Elsevier B.V.
Year: 2014

description: Drug delivery systems are widely researched and developed to improve the delivery of pharmaceutical compounds and molecules. The last few decades have seen a marked growth of the field fueled by increased number of researchers, research funding, venture capital and the number of start-ups. Collectively, the growth has led to novel systems that make use of micro/nano-particles, transdermal patches, inhalers, drug reservoir implants and antibody-drug conjugates. While the increased research activity is clearly an indication of proliferation of the field, clinical and commercial translation of early-stage research ideas is critically important for future growth and interest in the field. Here, we will highlight some of the examples of novel drug delivery systems that have undergone such translation. Specifically, we will discuss the developments, advantages, limitations and lessons learned from: (i) microparticle-based depot formulations, (ii) nanoparticle-based cancer drugs, (iii) transdermal systems, (iv) oral drug delivery systems, (v) pulmonary drug delivery, (vi) implants and (vii) antibody-drug conjugates. These systems have impacted treatment of many prevalent diseases including diabetes, cancer and cardiovascular diseases, among others. At the same time, these systems are integral and enabling components of products that collectively generate annual revenues exceeding US $100 billion. These examples provide strong evidence of the clinical and commercial impact of drug delivery systems.
Sonnenfleckenzeichnung Nr. 264.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 14.11.1985, 09:15, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1985

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Topical delivery of siRNA into skin using SPACE-peptide carriers
Creators: name: Anselmo, A.C.
name: Gupta, V.
name: Chen, M.
name: Mitragotri, S.
name: Muraski, J.A.
name: Slee, D.H.
name: Zakrewsky, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Short-interfering RNAs (siRNAs) offer a potential tool for the treatment of skin disorders. However, applications of siRNA for dermatological conditions are limited by their poor permeation across the stratum corneum of the skin and low penetration into the skin's viable cells. In this study, we report the use of SPACE-peptide in combination with a DOTAP-based ethosomal carrier system to enhance skin delivery of siRNA. A DOTAP-based SPACE Ethosomal System significantly enhanced siRNA penetration into porcine skin in vitro by 6.3 ± 1.7-fold (p < 0.01) with an approximately 10-fold (p < 0.01) increase in epidermis accumulation of siRNA compared to that from an aqueous solution. Penetration of siRNA was also enhanced at the cellular level. Internalization of SPACE-peptide occurred in a concentration dependent manner marked by a shift in intracellular distribution from punctate spots to diffused cytoplasmic staining at a peptide concentration of 10 mg/mL. In vitro delivery of GAPDH siRNA by SPACE peptide led to 83.3 ± 3.0% knockdown relative to the control. In vivo experiments performed using female BALB/C mice also confirmed the efficacy of DOTAP-SES in delivering GAPDH-siRNA into skin. Topical application of DOTAP-SES on mice skin resulted in 63.2% ± 7.7% of GAPDH knockdown, which was significantly higher than that from GAPDH-siRNA PBS (p < 0.05). DOTAP-SES formulation reported here may open new opportunities for cutaneous siRNA delivery.
Collaborative creation of teaching materials: Engaging students and lecturers in producing storytelling examples and cartoons
Creators: name: Demirbas, Erkan
name: Bird, Davina
name: Haque, Abdul
name: Charlesworth, Jane
Publisher: name: University of Lincoln
Year: 2024
Subjects: L100 - Economics

description: This presentation aims to explain how educators and students collaboratively develop stories and cartoons to teach economics.
Dephasing due to quasiparticle tunneling in fluxonium qubits: a phenomenological approach
Creators: name: Spilla, Samuele
name: Hassler, Fabian
name: Napoli, Anna
name: Splettstoesser, Janine
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The fluxonium qubit has arisen as one of the most promising candidate devices for implementing quantum information in superconducting devices, since it is both insensitive to charge noise (like flux qubits) and insensitive to flux noise (like charge qubits). Here, we investigate the stability of the quantum information to quasiparticle tunneling through a Josephson junction. Microscopically, this dephasing is due to the dependence of the quasiparticle transmission probability on the qubit state. We argue that on a phenomenological level the dephasing mechanism can be understood as originating from heat currents, which are flowing in the device due to possible effective temperature gradients, and their sensitivity to the qubit state. The emerging dephasing time is found to be insensitive to the number of junctions with which the superinductance of the fluxonium qubit is realised. Furthermore, we find that the dephasing time increases quadratically with the shunt-inductance of the circuit which highlights the stability of the device to this dephasing mechanism.
description: published version
ПРОБЛЕМНЫЕ АСПЕКТЫ УПРАВЛЕНИЯ ЦИФРОВЫМИ РЕСУРСАМИ
Creators: name: И. М. Пожарицкая
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: цифровые ресурсы
цифровая трансформация
управление
бизнеспроцессы
цифровой капитал
цифровое предпринимательство

description: Рассмотрены виды цифровых ресурсов: цифровой капитал, цифровые активы, цифровые знания, цифровые трудовые ресурсы, цифровое предпринимательство. Приведены проблемные вопросы управления по каждому виду цифровых ресурсов в условиях цифровой трансформации бизнес-процессов. Уточнены элементы управления цифровым предпринимательством.
Sonnenfleckenzeichnung Nr. 205.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 08.09.1985, 07:00, erstellt von Marco Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1985

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Sonnenfleckenzeichnung Nr. 265.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 15.11.1985, 08:30, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1985

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
General Covariance Constraints on Cosmological Correlators
Creators: name: Armendariz-Picon, Cristian
name: Neelakanta, Jayanth T.
name: Penco, Riccardo
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We study the extent to which diffeomorphism invariance restricts the properties of the primordial perturbations in single scalar field models. We derive a set of identities that constrain the connected correlators of the cosmological perturbations, as well as the one-particle-irreducible vertices of the theory in any gauge. These identities are the analogues of Slavnov-Taylor identities in gauge theories, and follow essentially from diffeomorphism invariance alone. Yet because quantization requires diffeomorphism invariance to be broken, they not only reflect invariance under diffeomorphisms, but also how the latter has been broken by gauge fixing terms. In order to not lose the symmetry altogether, we cannot simply set some fields to zero, as is usually done in cosmological perturbation theory, but need to decouple them smoothly and make sure that they do not contribute to cosmological correlators in the decoupling limit. We use these identities to derive a set of consistency relations between bispectra and power spectra of cosmological perturbations in different gauges. Without additional assumptions, these consistency relations just seem to reflect the redundancy implied by diffeomorphisms. But when combined with analyticity, in a formulation of the theory in which auxiliary fields have been integrated out, we recover novel and previously derived relations that follow from invariance under both time and spatial diffeomorphisms.
title: ÐÑÐ¾ÑÐµÑÑÑ Ð¿ÐµÑÐµÐ½Ð¾ÑÐ° Ð² Ð´Ð¸Ð½Ð°Ð¼Ð¸ÑÐµÑÐºÐ¸ Ð½ÐµÑÐ°Ð²Ð½Ð¾Ð²ÐµÑÐ½ÑÑ Ð³ÑÐ°Ð´Ð¸ÐµÐ½ÑÐ½ÑÑ ÑÐµÑÐµÐ½Ð¸ÑÑ Ð² ÐºÐ°Ð½Ð°Ð»Ðµ
title: ÑÐ¿ÐµÑÐ¸Ð°Ð»ÑÐ½Ð¾ÑÑÑ 1.3.14. Ð¢ÐµÐ¿Ð»Ð¾ÑÐ¸Ð·Ð¸ÐºÐ° Ð¸ ÑÐµÐ¾ÑÐµÑÐ¸ÑÐµÑÐºÐ°Ñ ÑÐµÐ¿Ð»Ð¾ÑÐµÑ Ð½Ð¸ÐºÐ°
titleType: Subtitle
Creators: name: Ð¨Ð°ÐºÐ¸ÑÐ¾Ð², Ð Ð°Ð´Ð¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: Ð¢ÐµÐ¿Ð»Ð¾ÑÐµÑ Ð½Ð¸ÐºÐ°
Ð¢ÑÑÐ±ÑÐ»ÐµÐ½ÑÐ½Ð¾Ðµ ÑÐµÑÐµÐ½Ð¸Ðµ
Ð´Ð¸Ð½Ð°Ð¼Ð¸ÑÐµÑÐºÐ°Ñ Ð½ÐµÑÐ°Ð²Ð½Ð¾Ð²ÐµÑÐ½Ð¾ÑÑÑ Ð¿Ð¾ÑÐ¾ÐºÐ°
ÑÐµÐ¿Ð»Ð¾Ð¾ÑÐ´Ð°ÑÐ° Ð½Ð° ÑÑÐµÐ½ÐºÐµ
Ð¾Ð¿ÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð¸Ð·Ð¼ÐµÑÐµÐ½Ð¸Ñ

description: ÐÐ¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ Ð¿ÑÐ¾Ð´Ð¾Ð»ÑÐ½Ð¾Ð³Ð¾ Ð³ÑÐ°Ð´Ð¸ÐµÐ½ÑÐ° Ð´Ð°Ð²Ð»ÐµÐ½Ð¸Ñ Ð½Ð° Ð¿Ð¾Ð³ÑÐ°Ð½Ð¸ÑÐ½ÑÐ¹ ÑÐ»Ð¾Ð¹, ÐºÐ°Ðº Ð¿ÑÐ°Ð²Ð¸Ð»Ð¾, Ð¿ÑÐ¸Ð²Ð¾Ð´Ð¸Ñ Ðº Ð²Ð¾Ð·Ð½Ð¸ÐºÐ½Ð¾Ð²ÐµÐ½Ð¸Ñ Ð´Ð¸Ð½Ð°Ð¼Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð½ÐµÑÐ°Ð²Ð½Ð¾Ð²ÐµÑÐ½Ð¾ÑÑÐ¸ ÑÐµÑÐµÐ½Ð¸Ñ. Ð­ÑÐ¾ Ð·Ð½Ð°ÑÐ¸ÑÐµÐ»ÑÐ½Ð¾ Ð·Ð°ÑÑÑÐ´Ð½ÑÐµÑ Ð¿ÑÐ¾Ð³Ð½Ð¾Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð¿Ð¾Ð³ÑÐ°Ð½Ð¸ÑÐ½Ð¾Ð³Ð¾ ÑÐ»Ð¾Ñ Ð¸ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ðµ Ð¸Ð½ÑÐµÐ³ÑÐ°Ð»ÑÐ½ÑÑ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸Ðº ÑÐµÑÐµÐ½Ð¸Ñ (ÑÐµÐ¿Ð»Ð¾Ð¾ÑÐ´Ð°ÑÐ°, Ð³Ð¸Ð´ÑÐ°Ð²Ð»Ð¸ÑÐµÑÐºÐ¾Ðµ ÑÐ¾Ð¿ÑÐ¾ÑÐ¸Ð²Ð»ÐµÐ½Ð¸Ðµ). ÐÐ°ÑÑÐ¾ÑÑÐ¸Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ñ Ð½Ð° ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÑ Ð¼ÐµÑÐ¾Ð´Ð¾Ð² Ð¿ÑÐ¾Ð³Ð½Ð¾Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÑÐµÐ¿Ð»Ð¾Ð¾ÑÐ´Ð°ÑÐ¸ Ð¸ ÑÑÑÐ±ÑÐ»ÐµÐ½ÑÐ½Ð¾ÑÑÐ¸ Ð² Ð´Ð¸Ð½Ð°Ð¼Ð¸ÑÐµÑÐºÐ¸ Ð½ÐµÑÐ°Ð²Ð½Ð¾Ð²ÐµÑÐ½ÑÑ Ð³ÑÐ°Ð´Ð¸ÐµÐ½ÑÐ½ÑÑ ÑÐµÑÐµÐ½Ð¸ÑÑ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¹ Ð² Ð´Ð¸ÑÑÑÐ·Ð¾ÑÐ½ÑÑ Ð¸ ÐºÐ¾Ð½ÑÑÐ·Ð¾ÑÐ½ÑÑ ÐºÐ°Ð½Ð°Ð»Ð°Ñ. ÐÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð¾ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½Ð¾Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÑÑÑÐºÑÑÑÑ Ð¿Ð¾ÑÐ¾ÐºÐ° Ð¸ ÐºÐ¾Ð½Ð²ÐµÐºÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ ÑÐµÐ¿Ð»Ð¾Ð¾Ð±Ð¼ÐµÐ½Ð° Ð² ÑÑÐ»Ð¾Ð²Ð¸ÑÑ Ð¿ÑÐ¾Ð´Ð¾Ð»ÑÐ½Ð¾Ð³Ð¾ Ð³ÑÐ°Ð´Ð¸ÐµÐ½ÑÐ° Ð´Ð°Ð²Ð»ÐµÐ½Ð¸Ñ Ð² Ð´Ð¸ÑÑÑÐ·Ð¾ÑÐ½ÑÑ Ð¸ ÐºÐ¾Ð½ÑÑÐ·Ð¾ÑÐ½ÑÑ ÐºÐ°Ð½Ð°Ð»Ð°Ñ. ÐÑÑÐ²Ð»ÐµÐ½Ñ Ð·Ð°ÐºÐ¾Ð½Ð¾Ð¼ÐµÑÐ½Ð¾ÑÑÐ¸ ÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÐºÐ¸Ð½ÐµÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÐ½ÐµÑÐ³Ð¸Ð¸ ÑÑÑÐ±ÑÐ»ÐµÐ½ÑÐ½Ð¾ÑÑÐ¸ Ð² Ð³ÑÐ°Ð´Ð¸ÐµÐ½ÑÐ½ÑÑ ÑÐµÑÐµÐ½Ð¸ÑÑ. ÐÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ñ ÑÐ°ÑÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ñ ÐºÐ¾ÑÑÑÐ¸ÑÐ¸ÐµÐ½ÑÐ° ÑÐµÐ¿Ð»Ð¾Ð¾ÑÐ´Ð°ÑÐ¸ Ð²Ð´Ð¾Ð»Ñ Ð½Ð°Ð³ÑÐµÑÐ¾Ð¹ ÑÑÐµÐ½ÐºÐ¸. ÐÐ¾Ð»ÑÑÐµÐ½Ñ Ð½Ð¾Ð²ÑÐµ ÐºÑÐ¸ÑÐµÑÐ¸Ð°Ð»ÑÐ½ÑÐµ Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÐ¸ Ð¸ Ð·Ð°ÐºÐ¾Ð½Ð¾Ð¼ÐµÑÐ½Ð¾ÑÑÐ¸, ÑÐ²ÑÐ·ÑÐ²Ð°ÑÑÐ¸Ðµ ÑÑÑÑÐºÑÑÑÑ Ð¿Ð¾ÑÐ¾ÐºÐ° Ð¸ ÑÐµÐ¿Ð»Ð¾Ð¾ÑÐ´Ð°ÑÑ Ð² Ð³ÑÐ°Ð´Ð¸ÐµÐ½ÑÐ½ÑÑ ÑÐµÑÐµÐ½Ð¸ÑÑ.
Sonnenfleckenzeichnung Nr. 231.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 04.10.1985, 08:30, erstellt von Michele Bianda, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1985

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Topical delivery of hyaluronic acid into skin using SPACE-peptide carriers
Creators: name: Gupta, V.
name: Mitragotri, S.
name: Anselmo, A.C.
name: Chen, M.
name: Muraski, J.A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Topical penetration of macromolecules into the skin is limited by their low permeability. Here, we report the use of a skin penetrating peptide, SPACE peptide, to enhance topical delivery of a macromolecule, hyaluronic acid (HA, MW: 200-325 kDa). The peptide was conjugated to phospholipids and used to prepare an ethosomal carrier system (~ 110 nm diameter), encapsulating HA. The SPACE-ethosomal system (SES) enhanced HA penetration into porcine skin in vitro by 7.8 +/- 1.1-fold compared to PBS. The system also enhanced penetration of HA in human skin in vitro, penetrating deep into the epidermis and dermis in skin of both species. In vivo experiments performed using SKH1 hairless mice also confirmed increased dermal penetration of HA using the delivery system; a 5-fold enhancement in penetration was found compared to PBS control. Concentrations of HA in skin were about 1000-fold higher than those in blood; confirming the localized nature of HA delivery into skin. The SPACE-ethosomal delivery system provides a formulation for topical delivery of macromolecules that are otherwise difficult to deliver into the skin.
Site-specific structural analysis of a yeast prion strain with species-specific seeding activity
Creators: name: Marcelino-Cruz, A.M.
name: Anselmo, A.C.
name: Bhattacharya, M.
name: Tessier, P.M.
Publisher: name: Landes Bioscience
Year: 2011

description: Prion proteins misfold and aggregate into multiple infectious strain variants that possess unique abilities to overcome prion species barriers, yet the structural basis for the species-specific infectivities of prion strains is poorly understood. Therefore, we have investigated the site-specific structural properties of a promiscuous chimeric form of the yeast prion Sup35 from Saccharomyces cerevisiae and Candida albicans. The Sup35 chimera forms two strain variants, each of which selectively infect one species but not the other. Importantly, the N-terminal and middle domains of the Sup35 chimera (collectively referred to as Sup35NM) contain two prion recognition elements (one from each species) that regulate the nucleation of each strain. Mutations in either prion recognition element significantly bias nucleation of one strain conformation relative to the other. Here we have investigated the folding of each prion recognition element for the serine-to-arginine mutant at residue 17 of the Sup35NM chimera known to promote nucleation of C. albicans strain conformation. Using cysteine-specific labeling analysis, we find that residues in the C. albicans prion recognition element are solvent-shielded, while those outside the recognition sequence (including most of those in the S. cerevisiae recognition element) are solvent-exposed. Moreover, we find that proline mutations in the C. albicans recognition sequence disrupt the prion templating activity of this strain conformation. Our structural findings reveal that differential folding of complementary and non-complementary prion recognition elements within the prion amyloid core of the Sup35NM chimera is the structural basis for its species-specific templating activity.
ОЦЕНКА ЭФФЕКТИВНОСТИ ИСПОЛЬЗОВАНИЯ ЧЕЛОВЕЧЕСКИХ РЕСУРСОВ
Creators: name: М. С. Рыбянцева
name: С. А. Асланова
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: человеческие ресурсы
производство
эффективность
результат
показатель
обязанность
сотрудник

description: В статье рассматривалась взаимосвязь человеческих ресурсов и процесса производства на основе анализа трудовых и экономических показателей. Эффективно использовать ресурсы – это означает добиваться больших результатов для достижения целей организации при низких затратах ресурсов: труда, времени, средств. Развитие трудового потенциала работников предприятия является следствием принятых управленческих решений, необходимых для получения дополнительного результата от процесса производства.
Sonnenfleckenzeichnung Nr. 242.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 15.10.1985, 09:30, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1985

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Brandon White Final Dissertation.pdf
Creators: name: White, Brandon C
Publisher: name: Purdue University Graduate School
Year: 2023
Subjects: Teacher education and professional development of educators

description: This qualitative study aimed to identify teaching competencies teachers attribute to student achievement and what evaluator feedback they want and need to improve their instruction. Participants from one school district were interviewed. The data were coded through the lens of Marzano’s (2017) Art and Science of Teaching Framework. Of Marzano’s 60 competencies, teachers overwhelmingly focused on competencies around engaging students, specifically noticing when students are not engaged. The participants in this study desired evaluator feedback on strategies to better engage students, yet did not identify, by name or insinuation, those teaching competencies critical to actually engaging students, such as planning and preparing content material or how to differentiate the delivery of content to meet each student’s needs. In essence, the art of teaching trumps the science of teaching when it comes to what teachers focus their instruction on and what they want feedback on. The data from this study also suggested participants were more likely to use feedback given by an evaluator if they respected the evaluator and their professional knowledge and skill in the teacher’s content area.
К ВОПРОСУ О ВАЖНЕЙШИХ АСПЕКТАХ УЧЕТА ФИНАНСОВЫХ ВЛОЖЕНИЙ
Creators: name: М. С. Рыбянцева
name: Е. О. Жукова
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: финансовые вложения
коммерческая организация
активы
вклад
ценные бумаги.

description: На современном этапе развития рыночных отношений все большую значимость приобретают вопросы учета финансовых вложений, как ключевого источника информации при определении стратегических направлений финансово-хозяйственной деятельности любой коммерческой организации. Вместе с тем, необходимость в реформировании устаревшего механизма учета в условиях перехода на международные стандарты требует адекватного информационного обеспечения, инструментом для которого выступают достоверные сведения бухгалтерской (финансовой) отчетности.
Sonnenfleckenzeichnung Nr. 240.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 13.10.1985, 08:30, erstellt von Marco Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1985

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
The Best Constraints on A Super-Eddington Accretion Flow: XMM-Newton Observations of An Intermediate-mass Black Hole
Creators: name: Jin, Chichuan
name: Done, Chris
name: Ward, Martin
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: RX J1140.1+0307 (hereafter RX1140) is a Narrow Line Seyfert 1 (NLS1) with one of the lowest black hole masses known in an AGN (M ${\le} 10^6$ M$_{\odot}$). We show results from two new {\it XMM-Newton} observations, showing soft 2-10~keV spectra, a strong excess at lower energies, and fast X-ray variability as is typical of this class. The soft excess can be equally well fit by either low temperature Comptonisation or highly smeared, ionised reflection models, but we use a covariance analysis of the fast X-ray variability as well as lag and coherence spectra to show that the low temperature Comptonisation model gives a better description of the break in variability properties between soft and hard X-rays. Both models also require an additional component at the softest energies, as expected from the accretion disc. However, this inner disc spectrum does not join smoothly onto the variable optical and far UV emission (which should be produced in the outer disc) unless the mass is underestimated by an order of magnitude. The variable optical and far UV emission instead suggests that $L/L_{Edd}\sim 10$ through the outer disc, in which case advection and/or wind losses are required to explain the observed broadband spectral energy distribution. However, the similarity of the X-ray properties of RX1140 to other simple NLS1 such as PG 1244+026, RE J1034+396 and RX~J0136 means it is likely that these are also super-Eddington sources. This means their spectral energy distribution cannot be used to determine black hole spin despite appearing to be disc dominated. It also means that the accretion geometry close to the black hole is unlikely to be a flat disc as assumed in the new X-ray reverberation mapping techniques.
description: 13 pages, 9 figures; submitted to MNRAS
СОВРЕМЕННЫЕ ТЕНДЕНЦИИ РАЗВИТИЯ АУДИТОРСКИХ УСЛУГ В РОССИИ
Creators: name: М. С. Рыбянцева
name: С. А. Кат
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: аудит; аудиторская деятельность в России; аудитор; аудиторские услуги; рынок аудиторских услуг

description: В данной статье анализируется современное состояние рынка аудиторских услуг в Российской Федерации. Рассмотрены динамика и структура доходов аудиторских организаций и аудиторских групп и сетей от оказания аудиторских и консалтинговых услуг. Представлены и проанализированы статистические данные о динамике деятельности аудиторских организаций. Сделан вывод об основных тенденциях, присущих российскому рынку аудиторских услуг.
Sonnenfleckenzeichnung Nr. 291.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 22.12.1985, 08:45, erstellt von Marco Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1985

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Recruitment, attrition and intervention completion in clinical trials of psychosocial interventions involving people with early and emerging psychosis: a systematic review protocol
Creators: name: Easpaig, Bróna Nic Giolla
name: Zhai, Jianxia
name: Gray, Richard
name: Brown, Ellie
name: Bressington, Daniel
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 52
subject: Psychology
subject: FOS: Psychology
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences

description: Introduction: Psychosocial interventions for people experiencing early and emerging psychosis have demonstrated efficacy in reducing symptom severity and supporting recovery; however, much remains unknown about optimising treatment and future research trials are required. Gaining a better understanding of feasibility in trials of psychosocial interventions involving this population would inform the design and planning of future research and support the development of high-quality evidence. The aim of this systematic review is to evaluate the recruitment rate, study attrition rates and intervention completion of psychosocial intervention randomised controlled trial studies involving people with early and emerging psychosis. Methods and analysis: The systematic review will be reported in adherence with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols 2015 guideline. The Cochrane Library, PubMed, Medline, PsycINFO, Web of Science and CINAHL databases will be searched from inception to September 2021 to identify potentially relevant studies. The title and abstracts of returned records will be assessed for eligibility against the inclusion/exclusion criteria by two reviewers, independently, and records which appear eligible will be included. The full texts of included records will then be assessed using the same procedure. Qualitative and quantitative synthesis will be undertaken. Proportion meta-analyses will be used to calculate the recruitment rate, study attrition rate and intervention completion rate, while subgroup analyses will explore differences among subgroups of study and intervention characteristics. Ethics and dissemination: This study will collate and analyse anonymised data from published research and therefore, ethical approval is not necessary. Study results will be disseminated via publication in academic journals.
BANQUE GÉNÉRALE КАК ВОПЛОЩЕНИЕ СИСТЕМЫ ДЖОНА ЛО
Creators: name: А. Д. Сергеева
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: Banque générale
Banque Royal
банковская деятельность
теория кредита Джона Ло
капиталотворческий эффект кредита.

description: В статье анализируются основные идеи теории кредита Джона Ло, воплощенные им в деятельности основанного во Франции в 1716 году Banque générale. Рассмотрены особенности системы Джона Ло с точки зрения возможности ее использования в современном мире. Приводится сравнение основных идей экономиста с идеями представителей таких школ, как кейнсианство и монетаризм. В результате исследования было выявлено, что идеи государственного регулирования экономики и эффективной денежно-кредитной политики используются в большинстве стран мире.
Enhancing quantum entanglement and quantum teleportation for two-mode squeezed vacuum state by local quantum-optical catalysis
Creators: name: Xu, Xue-xiang
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: I theoretically investigate how the entanglement properties of a two-mode squeezed vacuum state (TMSVS) can be enhanced by operating quantum-optical catalysis on each mode of the TMSVS. The quantum-optical catalysis is simply mixing one photon at the beam splitter and post-select the beam-splitter (BS) output based on detection of one photon, first proposed by Lvovsky and Mlynek [Phys. Rev. Lett. 88, 250401 (2002)]. I find that there exists some enhancement in the entanglement properties (namely, entanglement entropy, second-order Einstein-Podolsky-Rosen correlation, and the fidelity of quantum teleportation) in certain parameter ranges spanned by the low transmissivities of the BSs and the small squeezing parameter of the input TMSVS.
description: 13 pages, 20 figures. Close to published version. Revise a plus sign of Eq.(11) in page 5 of the journal version
Sonnenfleckenzeichnung Nr. 247.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 21.10.1985, 10:15, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1985

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
PRÓSPERO protocol.
Creators: name: Yugsi Artos, Steven Alexander
name: Viviana Vega Cando, Katherine
name: Guañuna Monteros, Odalys
name: Isabel Guzman Pichogagon, Rosa
name: Villacis Adrian Alexander, Valle
name: Alexander Oviedo Díaz, Nick
name: Ariana Solorzano Loor, Cielo
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 320221
subject: Psychiatry (incl. psychotherapy)

description: The Capgras syndrome is a rare psychotic disorder characterized by the delusional belief that one or more familiar persons have been replaced by identical impostors. The syndrome is usually associated with other neuropsychiatric conditions, such as schizophrenia, dementia, or brain injury. The exact causes and mechanisms of the Capgras syndrome are not fully understood, but some hypotheses suggest that it involves a disruption of the neural pathways that link facial recognition with emotional processing.Pharmacological treatment of Capgras syndrome is based on the underlying diagnosis and the severity of the symptoms. Antipsychotic drugs, such as haloperidol, risperidone, or olanzapine, are often prescribed to reduce delusions and hallucinations.
Antenna system characteristic and solar radio burst observation
Creators: name: Li, Sha
name: Yan, Yihua
name: Chen, Zhijun
name: Wang, Wei
name: Liu, Donghao
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Chinese Spectral Radio Heliograph (CSRH) is an advanced aperture synthesis solar radio heliograph, developed by National Astronomical Observatories, Chinese Academy of Sciences independently. It consists of 100 reflector antennas, which are grouped into two antenna arrays (CSRH-I and CSRH-II) for low and high frequency bands respectively. The frequency band of CSRH-I is 0.4-2GHz and for CSRH-II, the frequency band is 2-15GHz. In the antenna and feed system, CSRH uses an Eleven feed to receive signals coming from the Sun, the radiation pattern with lower side lobe and back lobe of the feed is well radiated. The characteristics of gain G and antenna noise temperature T effect the quality of solar radio imaging. For CSRH, measured G is larger than 60 dBi and $ T $ is less than 120K, after CSRH-I was established, we have successfully captured a solar radio burst between 1.2-1.6GHz on November 12, 2010 through this instrument and this event was confirmed through the observation of Solar Broadband Radio Spectrometer (SBRS) at 2.84GHz and Geostationary Operational Environmental Satellite (GOES). In addition, an image obtained from CSRH-I clearly reveals the profile of the solar radio burst. The other observational work is the imaging of Fengyun-2E geosynchronous satellite which is assumed to be a point source. This data processing method indicates that, the method of deleting errors about dirty image could be used for processing other surface sources.
СУЩНОСТЬ МЕТОДА «JUST-IN-TIME». ЕГО АДАПТАЦИЯ В ОТЕЧЕСТВЕННЫХ ОРГАНИЗАЦИЯХ ПИЩЕВОЙ ПРОМЫШЛЕННОСТИ
Creators: name: В. В. Сериков
name: И. А. Свищёва
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: концепция «Точно в срок»
снабженческо-заготовительный процесс
затоваривание
затраты на хранение материалов
бюджетирование
управленческий учет
экономика.

description: В условиях нестабильного рыночного механизма эффективность деятельности коммерческих организаций обуславливается не только оптимизацией производственного цикла, но и в первую очередь рациональной организацией снабженческозаготовительного процесса. В этой связи нами уточнена дефиниция и ключевые задачи метода «Just-in-Time», являющегося эффективным контуром управления. В последнее время проблема затоваривания наиболее остро затрагивает организации отрасли пищевой промышленности. С учетом данного обстоятельства, в данной статье на примере отечественного кондитерского комбината произведена адаптация зарубежной методики сокращения заготовительных затрат. Практическая значимость определяется успешной апробацией методики и выявлением экономического эффекта.
Fibrin gel enhances the antitumor effects of chimeric antigen receptor T cells in glioblastoma
Creators: name: Valdivia, A.
name: Savoldo, B.
name: Nandi, S.
name: Leon, E.
name: Du, H.
name: Khagi, S.
name: Dotti, G.
name: Gu, Z.
name: Hudson, H.
name: Hingtgen, S.
name: Yazdimamaghani, M.
name: Ligler, F.S.
name: Ogunnaike, E.A.
Publisher: name: American Association for the Advancement of Science
Year: 2021

description: Regional delivery of chimeric antigen receptor (CAR) T cells in glioblastoma represents a rational therapeutic approach as an alternative to intravenous administration to avoid the blood-brain barrier impediment. Here, we developed a fibrin gel that accommodates CAR-T cell loading and promotes their gradual release. Using a model of subtotal glioblastoma resection, we demonstrated that the fibrin-based gel delivery of CAR-T cells within the surgical cavity enables superior antitumor activity compared to CAR-T cells directly inoculated into the tumor resection cavity.
Sonnenfleckenzeichnung Nr. 289.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 20.12.1985, 08:45, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1985

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Sonnenfleckenzeichnung Nr. 230.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 03.10.1985, 09:30, erstellt von Sergio Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1985

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 4.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
ГОСУДАРСТВЕННАЯ ПОЛИТИКА РАЗВИТИЯ ЧЕЛОВЕЧЕСКОГО КАПИТАЛА В РОССИИ
Creators: name: Е. В. Слепцова
name: Т. И. Рындина
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: политика государственная
развитие
человеческий капитал
национальный проект.

description: Развитие человеческого капитала является приоритетной задачей реализации новой экономической политики РФ. В современной России, которая переходит в качественно новое состояние от стабилизации к инновационному социальноориентированному этапу развития, оно имеет особенное значение. Именно в этом и заключается основная концепция новой политики государства и национальных проектов. Мы считаем, что в основе формирования новой концепции и стратегии опережающего развития России должно быть развитие человеческого капитала. В статье рассмотрены ключевые вопросы государственной политики в области развития человеческого капитала
Bispecific binder redirected lentiviral vector enables in vivo engineering of CAR-T cells
Creators: name: Jacobs, T.M.
name: Dotti, G.
name: Huckaby, J.T.
name: Lai, S.K.
name: Landoni, E.
name: Savoldo, B.
Publisher: name: BMJ Publishing Group
Year: 2021

description: Background Chimeric antigen receptor (CAR) T cells have shown considerable promise as a personalized cellular immunotherapy against B cell malignancies. However, the complex and lengthy manufacturing processes involved in generating CAR T cell products ex vivo result in substantial production time delays and high costs. Furthermore, ex vivo expansion of T cells promotes cell differentiation that reduces their in vivo replicative capacity and longevity. Methods Here, to overcome these limitations, CAR-T cells are engineered directly in vivo by administering a lentivirus expressing a mutant Sindbis envelope, coupled with a bispecific antibody binder that redirects the virus to CD3 + human T cells. Results This redirected lentiviral system offers exceptional specificity and efficiency; a single dose of the virus delivered to immunodeficient mice engrafted with human peripheral blood mononuclear cells generates CD19-specific CAR-T cells that markedly control the growth of an aggressive pre-established xenograft B cell tumor. Conclusions These findings underscore in vivo engineering of CAR-T cells as a promising approach for personalized cancer immunotherapy.
Sonnenfleckenzeichnung Nr. 290.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 21.12.1985, 08:30, erstellt von Marco Cortesi, Sonnenobservatorium Specola Solare Ticinese in Locarno
Creators: name: Observatorium Specola Solare Ticinese Locarno (1957 bis 1980 Teil der Eidgenössischen Sternwarte der ETH Zürich)
Publisher: name: [s.n.]
Year: 1985

description: Bleistiftzeichnung mit schwarzer Farbe und Bleistift, erstellt als Projektionsbildzeichnung für die Beobachtungen in Locarno-Monti auf einem eigenen Vordruck. Instrument: Zeiss-Coudé-Refraktor mit 15 cm Öffnung und 225 cm Brennweite. Bildqualität (SIDC): 3.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden auf dem Vordruck eingetragen. Zusätzlich sind zuhanden der späteren statistischen Verarbeitung die Angaben für die Bestimmung der Fleckenrelativzahl notiert.
Beobachtungstätigkeit unter eigenständiger Leitung (Associazione Specola Solare Ticinese ASST)
Low-Order Mathematical Modelling of Electric Double Layer Supercapacitors Using Spectral Methods
Creators: name: Drummond, Ross
name: Howey, David A.
name: Duncan, Stephen R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Systems and Control (eess.SY)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Physical sciences

description: This work investigates two physics-based models that simulate the non-linear partial differential algebraic equations describing an electric double layer supercapacitor. In one model the linear dependence between electrolyte concentration and conductivity is accounted for, while in the other model it is not. A spectral element method is used to discretise the model equations and it is found that the error convergence rate with respect to the number of elements is faster compared to a finite difference method. The increased accuracy of the spectral element approach means that, for a similar level of solution accuracy, the model simulation computing time is approximately 50% of that of the finite difference method. This suggests that the spectral element model could be used for control and state estimation purposes. For a typical supercapacitor charging profile, the numerical solutions from both models closely match experimental voltage and current data. However, when the electrolyte is dilute or where there is a long charging time, a noticeable difference between the numerical solutions of the two models is observed. Electrical impedance spectroscopy simulations show that the capacitance of the two models rapidly decreases when the frequency of the perturbation current exceeds an upper threshold.
description: Pre-print submitted to Journal of Power Sources