cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Estrogen receptor β is associated with expression of cancer associated genes and survival in ovarian cancer
Creators: name: Schüler-Toprak, Susanne
name: Weber, Florian
name: Skrzypczak, Maciej
name: Ortmann, Olaf
name: Treeck, Oliver
Publisher: name: Universität Regensburg
Year: 2018
Subjects: subject: PROGESTERONE-RECEPTOR; PROGNOSTIC VALUE; DOWN-REGULATION; ER-BETA; CARCINOMA; GROWTH; CELLS; TISSUE; TAMOXIFEN; APOPTOSIS; Estrogen receptor; Ovarian cancer; Overall survival; Progression-free survival
subject: 610 Medizin

description: BackgroundIn ovarian cancer, the role of estrogen receptors (ERs), particularly of ER, being suggested as tumor suppressor in breast and prostate cancer, remains unclear. We examined the expression of nuclear and cytoplasmic ER in ovarian cancer and correlated it with expression of ovarian cancer markers CA125, CEA and CA72-4, steroid hormone receptors ER and PR, cancer-associated genes EGFR, p53, HER2 and proliferation marker Ki-67. Additionally we examined to what extent expression of ER and the other proteins affects survival of ovarian cancer patients.MethodsWe established a tissue microarray from 171 ovarian cancer patients and performed immunohistochemical analyses of the mentioned proteins.ResultsNuclear ER was detected in 47.31% of the ovarian cancer tissues and cytoplasmic expression of this receptor was observed in 23.08%. Nuclear expression of ER was significantly decreased in the G3 subgroup compared to better differentiated cancers (p<0.01) and correlated with ovarian cancer markers CEA (95% CI 0.1598-0.4465; p<0.0001) and CA72-4 (95% CI 0.05953-0.3616; p<0.01). Cytoplasmic ER expression correlated with EGFR levels (95% CI 0.1059-0.4049; p<0.001). ER expression was associated with expression of CA125 and PR. Overall survival of patients with tumors expressing cytoplasmic ER was significant longer compared to those with ER-negative ovarian cancer (chi-square statistic of the log-rank, p<0.05). Progression-free survival was dependent on expression of PR (chi-square statistic of the log-rank, p<0.05) and Ki-67 (p=0.05).ConclusionsOur data suggest an important, but distinct role of nuclear and cytoplasmic ER expression in ovarian cancer and encourage further studies on its role in this cancer entity.
title: Lettre n°1092 de Paul d'Estournelles de Constant à Nicholas Murray Butler (3 juin 1922)
title: Letter number 1092 from Paul d'Estournelles de Constant to Nicholas Murray Butler (June 3, 1922)
Creators: name: d'Estournelles de Constant, Paul
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: Pacifisme
Guerre mondiale (1914-1918)

description: Source: Archives de la Sarthe – France
Blanfordimys bucharensis
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Blanfordimys
Blanfordimys bucharensis

description: Blanfordimys bucharensis (Vinogradov 1930)
[Microtus] bucharensis Vinogradov 1930, Rukovodstvok opredeleniyu gryzunov Srednei Azii [Key to Determine Rodents of Central Asia]: 45.
Type Locality: Tajikistan, Zeravshan Range, 8 km S Pendzhikent, near village of Zivan, 2200 m.
Vernacular Names: Bucharian Vole.
Synonyms: Blanfordimys bucharicus (Vinogradov 1931); Blanfordimys davydovi Golenishchev and Sablina 1991.
Distribution: Mountains of SW Tajikistan, possibly N Afghanistan; limits unresolved.
Conservation: IUCN – Lower Risk (nt).
Discussion: Reviewed by Gromov and Erbajeva (1995). Ellerman (1941) listed bucharensis as species, but it is usually included in afghanus (Corbet, 1978 c; Ellerman and Morrison-Scott, 1951; Ognev, 1964; Pavlinov and Rossolimo, 1987). Morphometric analyses and chromosomal complement (2n = 48, FN = 52) indicate that bucharensis is distinct, with two morphological and geographical components, one newly described as the subspecies davydovi (Golenishchev and Sablina, 1991). See Pavlinov and Rossolimo (1987:195) for use of bucharensis instead of bucharicus.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 966, DOI: 10.5281/zenodo.7316535
Clinical Efficacy of a Novel Therapeutic Principle, Anakoinosis
Creators: name: Heudobler, Daniel
name: Rechenmacher, Michael
name: Lüke, Florian
name: Vogelhuber, Martin
name: Klobuch, Sebastian
name: Thomas, Simone
name: Pukrop, Tobias
name: Hackl, Christina
name: Herr, Wolfgang
name: Ghibelli, Lina
name: Gerner, Christopher
name: Reichle, Albrecht
Publisher: name: Universität Regensburg
Year: 2018
Subjects: subject: Anakoinosis, communicative reprogramming, transcriptional modulators, metronomic low-dose chemotherapy, glitazones, all-trans retinoic acid, COX-2 inhibitor, master modulators
subject: 610 Medizin

description: Classic tumor therapy, consisting of cytotoxic agents and/or targeted therapy, has not overcome therapeutic limitations like poor risk genetic parameters, genetic heterogeneity at different metastatic sites or the problem of undruggable targets. Here we summarize data and trials principally following a completely different treatment concept tackling systems biologic processes: the principle of communicative reprogramming of tumor tissues, i.e., anakoinosis (ancient greek for communication), aims at establishing novel communicative behavior of tumor tissue, the hosting organ and organism via re-modeling gene expression, thus recovering differentiation, and apoptosis competence leading to cancer control – in contrast to an immediate, “poisoning” with maximal tolerable doses of targeted or cytotoxic therapies. Therefore, we introduce the term “Master modulators” for drugs or drug combinations promoting evolutionary processes or regulating homeostatic pathways. These “master modulators” comprise a broad diversity of drugs, characterized by the capacity for reprogramming tumor tissues, i.e., transcriptional modulators, metronomic low-dose chemotherapy, epigenetically modifying agents, protein binding pro-anakoinotic drugs, such as COX-2 inhibitors, IMiDs etc., or for example differentiation inducing therapies. Data on 97 anakoinosis inducing schedules indicate a favorable toxicity profile: The combined administration of master modulators, frequently (with poor or no monoactivity) may even induce continuous complete remission in refractory metastatic neoplasia, irrespectively of the tumor type. That means recessive components of the tumor, successively developing during tumor ontogenesis, are accessible by regulatory active drug combinations in a therapeutically meaningful way. Drug selection is now dependent on situative systems characteristics, to less extent histology dependent. To sum up, anakoinosis represents a new substantive therapy principle besides novel targeted therapies.
title: Lettre n°208 de Paul d'Estournelles de Constant à Nicholas Murray Butler (11 janvier 1917)
title: Letter number 208 from Paul d'Estournelles de Constant to Nicholas Murray Butler (January 11, 1917)
Creators: name: d'Estournelles de Constant, Paul
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: Pacifisme
Guerre mondiale (1914-1918)

description: Source: Archives de la Sarthe – France
Comparison of two column agglutination tests for red blood cell antibody testing
Creators: name: Sawierucha, Jonas
name: Posset, Marion
name: Hähnel, Viola
name: Johnson, Christian L.
name: Hutchinson, James A.
name: Ahrens, Norbert
Publisher: name: Universität Regensburg
Year: 2018
Subjects: subject: SYSTEMS; GEL; AUTOANTIBODIES; ALLOANTIBODIES; PERFORMANCE; PERSISTENCE;
subject: 610 Medizin

description: Background 
Several sensitive methods are available for red blood cell (RBC) antibody screening. Among these, gel and glass card systems have demonstrated comparably good performance in retrospective studies and are widely used in routine patient diagnostics, but their performance in prospective studies has not been sufficiently characterised. 
Patients and methods 
Gel card (Bio-Rad DiaMed) and glass bead-based (Ortho Clinical Diagnostics) column agglutination technologies were used to screen for antibodies prospectively (group A) and for antibody identification in stored and fresh samples known to contain RBC antibodies retrospectively (group B). Untreated reagent RBCs and either papain-treated (Bio-Rad) or ficin-treated panel C cells (Ortho) were used for antibody identification. 
Results 
RBC-reactive antibodies were detected in 22 of 1000 group A samples, three of which tested positive only by gel card agglutination, and four only by glass bead agglutination (including one false positive each). Group B comprised 202 sera with known antibodies: 33 of these samples contained 36 antibodies detected only by gel card agglutination, whereas 9 samples contained antibodies detectable only by glass bead-based agglutination. Discrepancies mostly involved weak antibodies reactive by enzyme only. Two sera contained antibody mixtures that neither system detected completely. Of note, in antibody differentiation batches one and two, anti-Lu a was reactive in 7 of 7 and 1 of 8 samples, respectively. 
Conclusion 
Both column agglutination tests for red cell antibodies had equal sensitivity and specificity with unstored samples. In stored samples, weak and enzyme-only antibodies were more frequently detected with the gel card system.
"zpt_y2_y3.txt" of "A precise measurement of the Z-boson double-differential transverse momentum and rapidity distributions in the full phase space of the decay leptons with the ATLAS experiment at $\sqrt s$ = 8 TeV"
Creators: name: ATLAS Collaboration
Publisher: name: HEPData
Year: 2024

description: Correlation for $p_T$ cross section between 0.8 < |y| < 1.2 and 1.2 < |y| < 1.6
description: CERN-LHC. This paper presents for the first time a precise measurement of the production properties of the $Z$ boson in the full phase space of the decay leptons. This is in contrast to the many previous precise unfolded measurements performed in the fiducial phase space of the decay leptons. The measurement is obtained from proton--proton collision data collected by the ATLAS experiment in 2012 at $\sqrt{s} = 8$ TeV at the LHC and corresponding to an integrated luminosity of 20.2 fb$^{-1}$. The results, based on a total of 15.3 million $Z$-boson decays to electron and muon pairs, extend and improve a previous measurement of the full set of angular coefficients describing $Z$-boson decay. The double-differential cross-section distributions in $Z$-boson transverse momentum $p_T$ and rapidity $y$ are measured in the pole region, defined as $80 < m_{\ell\ell} < 100$ GeV, over the range $|y| < 3.6$. The total uncertainty of the normalised cross-section measurements in the peak region of the $p_T$ distribution is dominated by statistical uncertainties over the full range and increases as a function of rapidity from $0.5-1.0$% for $|y| < 2.0$ to $2-7$% at higher rapidities. The results for the rapidity-dependent transverse momentum distributions are compared to state-of-the-art QCD predictions, which combine in the best cases approximate N$^4$LL resummation with N$^3$LO fixed-order perturbative calculations. The differential rapidity distributions integrated over $p_T$ are even more precise, with accuracies from $0.2-0.3$% for $|y| < 2.0$ to $0.4-0.9$% at higher rapidities, and are compared to fixed-order QCD predictions using the most recent parton distribution functions. The agreement between data and predictions is quite good in most cases.
Diagnostic performance of Gd-EOB-DTPA-enhanced MRI for evaluation of liver dysfunction: a multivariable analysis of 3T MRI sequences
Creators: name: Verloh, Niklas
name: Utpatel, Kirsten
name: Zeman, Florian
name: Fellner, Claudia
name: Schlitt, Hans J.
name: Müller, Martina
name: Stroszczynski, Christian
name: Evert, Matthias
name: Wiggermann, Philipp
name: Haimerl, Michael
Publisher: name: Universität Regensburg
Year: 2018
Subjects: subject: 610 Medizin

description: Objective: 
The aim of this study was to evaluate the diagnostic performance of a multiparametric gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced MRI examination for the estimation of liver dysfunction classified by the Model for End-Stage Liver Disease (MELD) score.

Results: 
Liver dysfunction can be assessed by different methods. In a logistic regression analysis, T1- and T2-weighted images were affected by impaired liver function. In the assessment of liver dysfunction, the reduction rate in T1 mapping sequences showed a significant correlation in simple and multiple logistic regression.

Conclusion: 
Changes in Gd-EOB-DTPA-enhanced MRI between plain images and images obtained during the hepatobiliary phase allowed good prediction of liver dysfunction, especially when using T1 mapping sequences.

Materials and Methods: 
A total of 199 patients underwent contrast-enhanced MRI with a hepatocyte-specific contrast agent at 3T. In the multivariable analysis, the full range of available MRI sequences was used to estimate the liver dysfunction of patients with various MELD scores.
Myrmecaelurini Esben-Petersen 1918
Creators: name: Badano, Davide
name: Pantaleoni, Roberto Antonio
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Neuroptera
Myrmeleontidae

description: Tribe Myrmecaelurini Esben-Petersen, 1918
Diagnosis of 3 rd instar larva. Head capsule without prominent ocular tubercles; mandibles equipped with 3 teeth; median tooth longer than the other teeth; labial palpi four-articulated, segments 2–4 longer than the basal width of the mandible. Mesothoracic spiracles sessile. Thorax and abdomen with sessile setiferous processes. VIII abdominal sternite without odontoid processes, often equipped with digging setae; IX abdominal sternite wider than long, with prominent rastra.
Biological notes. This tribe includes both ambush hunters and pit-building species able to move both forward and backward.
Comments. Myrmecaelurini are characteristic of the steppes and deserts of the Palaearctic region while few species are reported for the Afrotropical region. The members of this tribe show a considerable variation in larval and adult characters therefore the internal relationships and with closely related tribes, such as Nesoleontini, need to be clarified.
description: Published as part of Badano, Davide & Pantaleoni, Roberto Antonio, 2014, The larvae of European Myrmeleontidae (Neuroptera), pp. 1-71 in Zootaxa 3762 (1) on page 41, DOI: 10.11646/zootaxa.3762.1.1, http://zenodo.org/record/4909357
Myrmecaelurus A. Costa 1855
Creators: name: Badano, Davide
name: Pantaleoni, Roberto Antonio
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Neuroptera
Myrmeleontidae
Myrmecaelurus

description: Myrmecaelurus A. Costa, 1855
Diagnosis. Mandibles with 3 teeth, the median tooth is the largest and closer to the apical tooth than to the basal tooth; the median and apical teeth are directly in contact and not separated by setae; external margin of the mandibles covered by long setae; ocular tubercle not prominent; pronotum covered with short and robust bristles; spiracles sessile; thorax equipped with sessile setiferous processes; metathoracic legs with a fringe of setae; VIII abdominal sternite without odontoid processes and provided with numerous digging setae; IX abdominal sternite ventrally covered by digging setae and equipped with very large rastra.
Examined species. M. trigrammus (Pallas, 1771).
Comments. The mainly Palaearctic genus Myrmecaelurus is not well delimited and it is often subdivided in different subgenera (Aspöck et al. 1980), in some case raised to genus level (Krivokhatsky 2011). The presence of notable morphological differences in the larvae belonging to Aspoeckiana Hölzel, 1969 and Nohoveus Navás, 1919 (Krivokhatsky 2011) further supports their status as separated genera.
description: Published as part of Badano, Davide & Pantaleoni, Roberto Antonio, 2014, The larvae of European Myrmeleontidae (Neuroptera), pp. 1-71 in Zootaxa 3762 (1) on page 41, DOI: 10.11646/zootaxa.3762.1.1, http://zenodo.org/record/4909357
Caryomys eva Thomas 1911
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Caryomys
Caryomys eva

description: Caryomys eva Thomas 1911
Caryomys eva Thomas 1911, Abstr. Proc. Zool. Soc. Lond., 1911 (90): 4.
Type Locality: China, Gansu (Kansu), SE of Tauchow, 10,000 ft (3028 m).
Vernacular Names: Eva's Red-backed Vole.
Synonyms: Caryomys alcinous (Thomas 1911); Caryomys aquilus (G. M. Allen 1912).
Distribution: China, mountains of S Gansu and adjoining Shaanxi, Sichuan, and Hubei, 2400-3600 m; Zhang et al. (1997) included Ningxia and Qinghai provinces in the distribution.
Conservation: IUCN – Lower Risk (lc) as Eothenomys eva.
Discussion: Listed as a member of Evotomys or Clethrionomys rufocanus by Hinton (1926 a), Ellerman and Morrison-Scott (1951), and Gromov and Polyakov (1977). Correctly acknowledged and revised as a species (of Eothenomys) by G. M. Allen (1940), Corbet (1978 c), Corbet and Hill (1992), and Kaneko (1992 c), as followed by Musser and Carleton (1993) and Pavlinov et al. (1995 a). Phallic morphology described by Yang et al. (1992) and contrasted with species of Eothenomys. Corbet and Hill (1992) noted that the southern populations (alcinous) have much darker upperparts and underparts than the slight frosting of typical eva. Kaneko’s (1991) morphometric analysis associated the holotypes of alcinous and aquilus among samples of eva.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 968, DOI: 10.5281/zenodo.7316535
Are There Gender-Dependent Study Habits of Medical Students in Times of the World Wide Web?
Creators: name: Benditz, Achim
name: Pulido, L.
name: Renkawitz, T.
name: Schwarz, T.
name: Grifka, J.
name: Weber, Markus
Publisher: name: Universität Regensburg
Year: 2018
Subjects: subject: LEARNING STYLE PREFERENCES; ACHIEVEMENT;
subject: 610 Medizin

description: This study evaluates how medical students rate the different types of teaching materials and methods available as well as possible gender-specific differences in the use of such materials. In this descriptive, cross-sectional study a questionnaire with short, one-dimensional questions with a 4-step Likert scale was developed by a presurvey within 493 students (4th year) at a University Medical School (January-December 2015). The anonymous survey was performed from July 2016 to February 2017 with 252 students within an orthopaedic surgery course at University Medical School. After exclusion of (1) nonnative speakers and (2) incomplete forms, 233 samples were included. Practical education was regarded as the most important (n=160/68.7%) teaching method followed by Internet research (n=147/63.1%) as the most important teaching material, while traditional frontal teaching (n=19/8.2%) and e-books (n=11/4.7%) ranked last. The evaluation of gender-specific differences in the use of teaching materials showed that female students prefer to highlight text (p<0.0001) as well as a trend to Internet research (p=0.053) and small-group teaching (p=0.057). Despite some gender-specific differences, traditional learning methods retain their importance besides new learning possibilities such as Internet research.
Kronologia tabelo + Elĉerpoj (p. 12)
Creators: name: Péraire, Lucien
name: CNRS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023

description: created: 27-7-1928
HER4 expression in estrogen receptor-positive breast cancer is associated with decreased sensitivity to tamoxifen treatment and reduced overall survival of postmenopausal women
Creators: name: Wege, Anja Kathrin
name: Chittka, Dominik
name: Buchholz, Stefan
name: Klinkhammer-Schalke, Monika
name: Diermeier-Daucher, Simone
name: Zeman, Florian
name: Ortmann, Olaf
name: Brockhoff, Gero
Publisher: name: Universität Regensburg
Year: 2018
Subjects: subject: MEDIATES ACQUIRED-RESISTANCE; ENDOCRINE THERAPY; CROSS-TALK; IN-SITU; GROWTH; ERBB4; TRASTUZUMAB; MECHANISMS; PROTEIN; COEXPRESSION; HER4 receptor; Estrogen receptor positive breast cancer; Tamoxifen treatment
subject: 610 Medizin

description: BackgroundThe sensitivity of estrogen receptor-positive breast cancers to tamoxifen treatment varies considerably, and the molecular mechanisms affecting the response rates are manifold. The human epidermal growth factor receptor-related receptor HER2 is known to trigger intracellular signaling cascades that modulate the activity of coregulators of the estrogen receptor which, in turn, reduces the cell sensitivity to tamoxifen treatment. However, the impact of HER2-related receptor tyrosine kinases HER1, HER3, and, in particular, HER4 on endocrine treatment is largely unknown.MethodsHere, we retrospectively evaluated the importance of HER4 expression on the outcome of tamoxifen- and aromatase inhibitor-treated estrogen receptor-positive breast cancer patients (n=258). In addition, we experimentally analyzed the efficiency of tamoxifen treatment as a function of HER4 co-expression in vitro.ResultsWe found a significantly improved survival in tamoxifen-treated postmenopausal breast cancer patients in the absence of HER4 compared with those with pronounced HER4 expression. In accordance with this finding, the sensitivity to tamoxifen treatment of estrogen and HER4 receptor-positive ZR-75-1 breast cancer cells can be significantly enhanced by HER4 knockdown.ConclusionWe suggest an HER4/estrogen receptor interaction that impedes tamoxifen binding to the estrogen receptor and reduces treatment efficiency. Whether the sensitivity to tamoxifen treatment can be enhanced by anti-HER4 targeting needs to be prospectively evaluated.
Caryomys inez
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Caryomys
Caryomys inez

description: Caryomys inez (Thomas 1908)
[Microtus (Eothenomys)] inez Thomas 1908, Abstr. Proc. Zool. Soc. Lond., 1908 (63): 45.
Type Locality: China, Shanxi (Shansi), mtns 12 mi (19 km) NW Kolanchow, 7000 ft (2134 m).
Vernacular Names: Inez's Red-backed Vole.
Synonyms: Caryomys nux (Thomas 1910).
Distribution: N Sichuan and SE Shaanxi through Shanxi provinces, China, possibly farther east.
Conservation: IUCN – Lower Risk (lc) as Eothenomys inez.
Discussion: Following Hinton (1926 a), inez was synonymized with Clethrionomys rufocanus (Ellerman and Morrison-Scott, 1951; Gromov and Polyakov, 1977), but its distinctive status is well documented, typically within Eothenomys (G. M. Allen, 1940; Corbet, 1978 c; Corbet and Hill, 1992; Kaneko, 1992 c). Hinton (1926 a) and Ellerman and Morrison-Scott (1951) allocated nux to Clethrionomys rufocanus shanseius, but G. M. Allen (1940) treated it as a subspecies of Eothenomys inez. Kaneko’s (1991) morphometric analysis identified the holotype of nux as an example of inez, as concluded earlier by A. B. Howell (1929). Kaneko restricted the range to Shaanxi and Shanxi provinces, but Zhang et al. (1997) mapped a far broader distribution.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 968, DOI: 10.5281/zenodo.7316535
Time course of chemotaxis and chemokinesis of neutrophils following stimulation with IL-8 or FMLP
Creators: name: Hattenkofer, Matthias
name: Gruber, Michael
name: Metz, Sophia
name: Pfaehler, Sophie-Marie
name: Lehle, Karla
name: Trabold, Benedikt
Publisher: name: Universität Regensburg
Year: 2018
Subjects: subject: ; Chemotaxis; FMLP; IL-8; neutrophils; PMNs
subject: 610 Medizin

description: Polymorphonuclear cells (PMNs) attend to inflammatory sites by chemotactic movement, caused by chemoattractants (CAs) like n-formyl-l-methionyl-l-leucyl-l-phenylalanine (FMLP) and interleukin-8 (IL-8). However, distinct but applicable assays for investigations of PMNs' migration limit in vitro examination. We integrated CD15-bead-based isolation of PMNs with analysing their chemotaxis in a novel 3D-mu-Slide migration chamber. The PMNs were exposed to different concentrations of FMLP and IL-8 (1, 10 and 100 nM) and observed for 180 min in cell-physiological environment conditions. Moving PMNs' percentage (median and interquartile range) decreased from 62% (27%) to 36% (31%) without CA, from 88% (30%) to 22% (26%) for 1 nM IL-8, from 70% (22%) to 28% (13%) for 100 nM IL-8, from 30% (23%) to 18% (46%) for 1 nM FMLP and from 76% (20%) to 28% (13%) for 100 nM FMLP. Centres of cell movement turned towards the CAs (negative values) within a single 30-min observation period: 5.37 mu m (16.82 mu m) without CA, -181.37 mu m (132.18 mu m) with 10 nM and -239.34 mu m (152.19 mu m) with 100 nM IL-8; -116.2 mu m (69.07 mu m) with 10 nM and -71.59 mu m (98.58 mu m) with 100 nM FMLP. FMLP and IL-8 ensure chemotaxis without increase of chemokinesis. 3D-mu-Slide chemotaxis chambers facilitate time course analyses of PMNs' migration in stable conditions over a long time with concise distinction of chemotaxis and chemokinesis.
"zpt_y2_y4.txt" of "A precise measurement of the Z-boson double-differential transverse momentum and rapidity distributions in the full phase space of the decay leptons with the ATLAS experiment at $\sqrt s$ = 8 TeV"
Creators: name: ATLAS Collaboration
Publisher: name: HEPData
Year: 2024

description: Correlation for $p_T$ cross section between 0.8 < |y| < 1.2 and 1.6 < |y| < 2.0
description: CERN-LHC. This paper presents for the first time a precise measurement of the production properties of the $Z$ boson in the full phase space of the decay leptons. This is in contrast to the many previous precise unfolded measurements performed in the fiducial phase space of the decay leptons. The measurement is obtained from proton--proton collision data collected by the ATLAS experiment in 2012 at $\sqrt{s} = 8$ TeV at the LHC and corresponding to an integrated luminosity of 20.2 fb$^{-1}$. The results, based on a total of 15.3 million $Z$-boson decays to electron and muon pairs, extend and improve a previous measurement of the full set of angular coefficients describing $Z$-boson decay. The double-differential cross-section distributions in $Z$-boson transverse momentum $p_T$ and rapidity $y$ are measured in the pole region, defined as $80 < m_{\ell\ell} < 100$ GeV, over the range $|y| < 3.6$. The total uncertainty of the normalised cross-section measurements in the peak region of the $p_T$ distribution is dominated by statistical uncertainties over the full range and increases as a function of rapidity from $0.5-1.0$% for $|y| < 2.0$ to $2-7$% at higher rapidities. The results for the rapidity-dependent transverse momentum distributions are compared to state-of-the-art QCD predictions, which combine in the best cases approximate N$^4$LL resummation with N$^3$LO fixed-order perturbative calculations. The differential rapidity distributions integrated over $p_T$ are even more precise, with accuracies from $0.2-0.3$% for $|y| < 2.0$ to $0.4-0.9$% at higher rapidities, and are compared to fixed-order QCD predictions using the most recent parton distribution functions. The agreement between data and predictions is quite good in most cases.
Long-term survival after percutaneous irreversible electroporation of inoperable colorectal liver metastases
Creators: name: Schicho, Andreas
name: Niessen, Christoph
name: Haimerl, Michael
name: Wiesinger, Isabel
name: Stroszczynski, Christian
name: Beyer, Lukas P.
name: Wiggermann, Philipp
Publisher: name: Universität Regensburg
Year: 2018
Subjects: subject: LOCAL TUMOR PROGRESSION; RADIOFREQUENCY ABLATION; SYSTEMIC CHEMOTHERAPY; CANCER; FLUOROURACIL; LEUCOVORIN; MANAGEMENT; MARGINS; MALIGNANCIES; OXALIPLATIN; liver metastases; survival; colorectal cancer; irreversible electroporation; long-term; salvage treatment; CRLM
subject: 610 Medizin

description: Background: For colorectal liver metastases (CRLM) that are not amenable to surgery or thermal ablation, irreversible electroporation (IRE) is a novel local treatment modality and additional option. Methods: This study is a retrospective long-term follow-up of patients with CRLM who underwent IRE as salvage treatment. Results: Of the 24 included patients, 18(75.0%) were male, and the median age was 57 (range: 28-75) years. The mean time elapsed from diagnosis to IRE was 37.9 +/- 37.3 months. Mean overall survival was 26.5 months after IRE (range: 2.5-69.2 months) and 58.1 months after diagnosis (range: 14.8-180.1 months). One-, three-, and five-year survival rates after initial diagnosis were 100.0%, 79.2%, and 41.2%; after IRE, the respective survival rates were 79.1%, 25.0%, and 8.3%. There were no statistically significant differences detected in survival after IRE with respect to gender, age, T- or N-stage at the time of diagnosis, size of metastases subject to IRE, number of hepatic lesions, or time elapsed between IRE and diagnosis. Conclusion: For nonresectable CRLM, long-term survival data emphasize the value of IRE as a new minimally invasive local therapeutic approach in multimodal palliative treatment, which is currently limited to systemic or regional therapies in this setting.
Chionomys gud Satunin 1909
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Chionomys
Chionomys gud

description: Chionomys gud Satunin 1909
Chionomys gud Satunin 1909, Izv. Kavkas. Mus., 4: 272.
Type Locality: Georgia, Caucasus Mtns, Gudaur, near Krestovskii Pass.
Vernacular Names: Gudaur Snow Vole.
Synonyms: Chionomys gotschobi (Shidlovsky 1919); Chionomys ighesicus (Ellerman and Morrison-Scott 1951); Chionomys lasistanius (Neuhäuser 1936); Chionomys lghesicus (Shidlovsky 1919); Chionomys lucidus (Shidlovsky 1919); Chionomys nenjukovi Formosov 1931; Chionomys oseticus (Shidlovsky 1919).
Distribution: Caucasus in Russia, Georgia, and Azerbaijan, and the E Black Sea Mtns of NE Turkey.
Conservation: IUCN – Lower Risk (nt).
Discussion: Ellerman and Morrison-Scott (1951) and Corbet (1978 c) listed gotschobi and lghesicus as synonyms of nivalis, but Pavlinov and Rossolimo (1987, 1998) and Pavlinov et al. (1995 a) included them in C. gud. Dental traits indicate a closer relationship to C. roberti than to C. nivalis (Nadachowski, 1991). In Turkey, the species has been collected at the same localities as C. nivalis but prefers more mesic habitats (Kryštufek, 1999 c).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 969, DOI: 10.5281/zenodo.7316535
"zpt_y2_y5.txt" of "A precise measurement of the Z-boson double-differential transverse momentum and rapidity distributions in the full phase space of the decay leptons with the ATLAS experiment at $\sqrt s$ = 8 TeV"
Creators: name: ATLAS Collaboration
Publisher: name: HEPData
Year: 2024

description: Correlation for $p_T$ cross section between 0.8 < |y| < 1.2 and 2.0 < |y| < 2.4
description: CERN-LHC. This paper presents for the first time a precise measurement of the production properties of the $Z$ boson in the full phase space of the decay leptons. This is in contrast to the many previous precise unfolded measurements performed in the fiducial phase space of the decay leptons. The measurement is obtained from proton--proton collision data collected by the ATLAS experiment in 2012 at $\sqrt{s} = 8$ TeV at the LHC and corresponding to an integrated luminosity of 20.2 fb$^{-1}$. The results, based on a total of 15.3 million $Z$-boson decays to electron and muon pairs, extend and improve a previous measurement of the full set of angular coefficients describing $Z$-boson decay. The double-differential cross-section distributions in $Z$-boson transverse momentum $p_T$ and rapidity $y$ are measured in the pole region, defined as $80 < m_{\ell\ell} < 100$ GeV, over the range $|y| < 3.6$. The total uncertainty of the normalised cross-section measurements in the peak region of the $p_T$ distribution is dominated by statistical uncertainties over the full range and increases as a function of rapidity from $0.5-1.0$% for $|y| < 2.0$ to $2-7$% at higher rapidities. The results for the rapidity-dependent transverse momentum distributions are compared to state-of-the-art QCD predictions, which combine in the best cases approximate N$^4$LL resummation with N$^3$LO fixed-order perturbative calculations. The differential rapidity distributions integrated over $p_T$ are even more precise, with accuracies from $0.2-0.3$% for $|y| < 2.0$ to $0.4-0.9$% at higher rapidities, and are compared to fixed-order QCD predictions using the most recent parton distribution functions. The agreement between data and predictions is quite good in most cases.
Biomarker Supervised G-CSF (Filgrastim) Response in ALS Patients
Creators: name: Johannesen, Siw Wollebæk
name: Budeus, Bettina
name: Peters, Sebastian
name: Iberl, Sabine
name: Meyer, Anne-Louise
name: Kammermaier, Tina
name: Wirkert, Eva
name: Bruun, Tim-Henrik
name: Samara, Verena C.
name: Schulte-Mattler, Wilhelm
name: Herr, Wolfgang
name: Schneider, Armin
name: Grassinger, Jochen
name: Bogdahn, Ulrich
Publisher: name: Universität Regensburg
Year: 2018
Subjects: subject: amyotrophic lateral sclerosis, granulocyte-colony stimulating factor, cytokines, hematopoietic stem and progenitor cells, HSPC, treatment
subject: 610 Medizin

description: Objective: To evaluate safety, tolerability and feasibility of long-term treatment with Granulocyte-colony stimulating factor (G-CSF), a well-known hematopoietic stem cell factor, guided by assessment of mobilized bone marrow derived stem cells and cytokines in the serum of patients with amyotrophic lateral sclerosis (ALS) treated on a named patient basis.

Methods: 36 ALS patients were treated with subcutaneous injections of G-CSF on a named patient basis and in an outpatient setting. Drug was dosed by individual application schemes (mean 464 Mio IU/month, range 90-2160 Mio IU/month) over a median of 13.7 months (range from 2.7 to 73.8 months). Safety, tolerability, survival and change in ALSFRS-R were observed. Hematopoietic stem cells were monitored by flow cytometry analysis of circulating CD34+ and CD34+CD38− cells, and peripheral cytokines were assessed by electrochemoluminescence throughout the intervention period. Analysis of immunological and hematological markers was conducted.

Results: Long term and individually adapted treatment with G-CSF was well tolerated and safe. G-CSF led to a significant mobilization of hematopoietic stem cells into the peripheral blood. Higher mobilization capacity was associated with prolonged survival. Initial levels of serum cytokines, such as MDC, TNF-beta, IL-7, IL-16, and Tie-2 were significantly associated with survival. Continued application of G-CSF led to persistent alterations in serum cytokines and ongoing measurements revealed the multifaceted effects of G-CSF.

Conclusions: G-CSF treatment is feasible and safe for ALS patients. It may exert its beneficial effects through neuroprotective and -regenerative activities, mobilization of hematopoietic stem cells and regulation of pro- and anti-inflammatory cytokines as well as angiogenic factors. These cytokines may serve as prognostic markers when measured at the time of diagnosis. Hematopoietic stem cell numbers and cytokine levels are altered by ongoing G-CSF application and may potentially serve as treatment biomarkers for early monitoring of G-CSF treatment efficacy in ALS in future clinical trials.
Nesoleontini Markl 1954
Creators: name: Badano, Davide
name: Pantaleoni, Roberto Antonio
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Neuroptera
Myrmeleontidae

description: Tribe Nesoleontini Markl, 1954
Diagnosis of 3 rd instar larva. Head capsule without prominent ocular tubercles; mandibles equipped with 3 teeth; median tooth longer than the other teeth; external margin of the mandible with long setae; labial palpi fourarticulated, segments 2–4 longer than the basal width of the mandible. Mesothoracic spiracles raised on a very short tubercle. Thorax and abdomen provided with sessile setiferous processes. Metathoracic legs with a fringe of setae. VIII abdominal sternite with odontoid processes; IX abdominal sternite wider than long, with prominent rastra.
Biological notes. Pit-builder antlions also able to perform ambush hunting, they can move both forward and backward.
Comments. The tribe Nesoleontini comprises only 3 genera; two of them are limited to the Afrotropical region, while Cueta is widespread in the Old World (Stange 2004). The larvae are extremely similar to those of Myrmecaelurini, from which they differ only in small details, suggesting a close relationship between these two tribes set apart due to some adult characters, notably genitalia.
description: Published as part of Badano, Davide & Pantaleoni, Roberto Antonio, 2014, The larvae of European Myrmeleontidae (Neuroptera), pp. 1-71 in Zootaxa 3762 (1) on page 43, DOI: 10.11646/zootaxa.3762.1.1, http://zenodo.org/record/4909357
title: Activité du port de Saint-Malo – 1684 – Plymouth
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: matériaux de construction
subject: textiles

description: Catégories de marchandises arrivées à Saint-Malo : matériaux de construction ; textiles
description: Cette fiche est issue de l’enquête menée par Jean Delumeau sur l’activité du port de Saint-Malo au 17e et 18e siècle. Cette fiche correspond à l’activité de l’année 1684 avec le port "Plymouth"
description: Marchandises arrivées à Saint-Malo : ardoises ; draps
description: Coverage: Grand commerce
description: Bibliographic citation: PERSON, Marie-Claire. Le Commerce maritime de Saint-Malo en 1684-1685. DES : Histoire : Rennes, 1962 (Bibliothèque François-Lebrun - Rennes 2, MH 1002)
description: date: Date de numérisation : 2021 à 2023
description: created: Années 1950-1960
Cutaneous leukemic infiltrates successfully treated with biomodulatory therapy in a rare case of therapy-related high risk MDS/AML
Creators: name: Heudobler, Daniel
name: Klobuch, Sebastian
name: Thomas, Simone
name: Hahn, Joachim
name: Herr, Wolfgang
name: Reichle, Albrecht
Publisher: name: Universität Regensburg
Year: 2018
Subjects: subject: ACUTE MYELOID-LEUKEMIA; SYSTEMS; leukemic skin infiltration; myelodysplastic syndrome; acute myeloid leukemia; biomodulatory treatment; anakoinosis
subject: 610 Medizin

description: Cutaneous manifestations in hematologic malignancies, especially in leukemia, are not common and may be very variable. Here we report a very unusual case of a patient (female, 70 years old) who was admitted to the hospital in 2016 because of skin lesions on the face, the trunk of the body and the extremities. She had a history of breast cancer in the year 2004 (pT1b, pN0, cM0, L0, V0, R0) which had been resected and treated with adjuvant radiation and chemotherapy (cyclophosphamide, methotrexate, 5-fluorouracile) as well as psoriasis treated with methotrexate and cyclosporine. Because of mild cytopenia a bone marrow aspirate/biopsy was performed showing myelodysplastic syndrome (MDS) with multilineage dysplasia. Cytogenetic review revealed a complex aberrant karyotype denoting adverse outcome. Simultaneously, a skin biopsy could confirm leukemic skin infiltration. Consequently, a therapy with azacitidine was started. After the first cycle the patient developed severe pancytopenia with a percentage of 13% peripheral blasts (previously 0-2%) as well as fever without evidence for infection which was interpreted as progressive disease. Therefore, the therapeutic regimen was changed to a biomodulatory therapy consisting of low-dose azacitidine 75 mg/day (given sc d1 -7 of 28), pioglitazone 45 mg/day per os, and all-trans-retinoic acid (ATRA) 45 mg/m(2)/day per os. After cycle 1 of this combined biomodulatory therapy the patient showed hematologic recovery; besides a mild anemia (hemoglobin 11.1 g/dl) she developed a normal blood count. Moreover, the cutaneous leukemic infiltrates which had been unaffected by the azacitidine ameliorated tremendously after 2 cycles resulting in a complete remission of the skin lesions after cycle 6. In conclusion, we report a very unusual case with cutaneous infiltrates being the first clinical manifestation of hematologic disease, preceding the development of acute myeloid leukemia. While azacitidine alone was ineffective, a combined biomodulatory approach resulted in a complete remission of the cutaneous manifestation.
Use of statins or NSAIDs and survival of patients with high-grade glioma
Creators: name: Seliger, Corinna
name: Schaertl, Julia
name: Gerken, Michael
name: Luber, Christian
name: Proescholdt, Martin
name: Riemenschneider, Markus J.
name: Leitzmann, Michael F.
name: Hau, Peter
name: Klinkhammer-Schalke, Monika
Publisher: name: Universität Regensburg
Year: 2018
Subjects: subject: NONSTEROIDAL ANTIINFLAMMATORY DRUGS; HUMAN GLIOBLASTOMA CELLS; LOW-DOSE ASPIRIN; NEWLY-DIAGNOSED GLIOBLASTOMA; PHASE-II; METRONOMIC CHEMOTHERAPY; VENOUS THROMBOEMBOLISM; ADJUVANT TEMOZOLOMIDE; CELECOXIB; PROLIFERATION;
subject: 610 Medizin

description: Background High-grade glioma (HGG) is associated with a limited prognosis. Drug repurposing has become of increasing interest to improve standard therapy. Statins and NSAIDs inhibit glioma cell growth in vitro and in vivo, but data on statin and NSAID treatment in relation to survival of patients with HGG are sparse. Methods We performed multivariable adjusted Cox-regression analyses among 1,093 patients with HGG from a regional cancer registry to obtain Hazard Ratios (HRs) with 95% Confidence Intervals (CIs) for overall survival (OS) and progression-free survival (PFS) according to treatment with statins or NSAIDs. Data on dose and duration of treatment was mostly lacking in our analysis, therefore we were not able to perform dose-response analyses. Results Use of statins was unrelated to OS or PFS of glioma patients. Use of aspirin was associated with prolonged OS and PFS in patients with WHO grade III, but not WHO grade IV glioma. Use of other NSAIDs (diclofenac, ibuprofen) or non-NSAID analgesics (paracetamol) was mostly unrelated to survival of glioma patients. Use of selective COX-2 inhibitors and metamizol was related to inferior patient survival in parts of the analyses. Conclusions Use of statins or NSAIDS, including aspirin, was not associated with prolonged OS or PFS of patients with WHO grade IV glioma in our selected cohort. There was an indication for improved survival in patients with WHO grade III glioma using aspirin, but further studies are needed to confirm our first observation.
Cueta Navas 1911
Creators: name: Badano, Davide
name: Pantaleoni, Roberto Antonio
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Neuroptera
Myrmeleontidae
Cueta

description: Cueta Navás, 1911
Diagnosis. Anterior margin of the clypeo-labrum with a small median incision; mandibles with 3 teeth, the median tooth is the strongest and it is closer to the apical tooth than to the basal tooth; at least 1 seta is always present between the median and apical teeth; external margin of the mandibles provided with long setae; pronotum covered with short setae; mesothoracic spiracle raised on a very short tubercle, abdominal spiracles inconspicuous; thorax with sessile setiferous processes; metathoracic legs with a fringe of setae; VIII abdominal sternite with odontoid process and digging setae; IX sternite with an anterior group of two pairs of digging setae and two rastra each bearing 4 digging setae, one large digging seta is disposed at the base of each rastrum.
Examined species. C. lineosa (Rambur, 1842); C. beieri Hölzel, 1969.
Comments. The genus Cueta comprises at least 80 known species distributed in the arid areas of Eurasia and Africa (Stange 2004). The larvae are known only for a handful of species (Willmann 1977; Stange et al. 2003; Krivokhatsky 2011).
description: Published as part of Badano, Davide & Pantaleoni, Roberto Antonio, 2014, The larvae of European Myrmeleontidae (Neuroptera), pp. 1-71 in Zootaxa 3762 (1) on page 43, DOI: 10.11646/zootaxa.3762.1.1, http://zenodo.org/record/4909357
"zpt_y2_y6.txt" of "A precise measurement of the Z-boson double-differential transverse momentum and rapidity distributions in the full phase space of the decay leptons with the ATLAS experiment at $\sqrt s$ = 8 TeV"
Creators: name: ATLAS Collaboration
Publisher: name: HEPData
Year: 2024

description: Correlation for $p_T$ cross section between 0.8 < |y| < 1.2 and 2.4 < |y| < 2.8
description: CERN-LHC. This paper presents for the first time a precise measurement of the production properties of the $Z$ boson in the full phase space of the decay leptons. This is in contrast to the many previous precise unfolded measurements performed in the fiducial phase space of the decay leptons. The measurement is obtained from proton--proton collision data collected by the ATLAS experiment in 2012 at $\sqrt{s} = 8$ TeV at the LHC and corresponding to an integrated luminosity of 20.2 fb$^{-1}$. The results, based on a total of 15.3 million $Z$-boson decays to electron and muon pairs, extend and improve a previous measurement of the full set of angular coefficients describing $Z$-boson decay. The double-differential cross-section distributions in $Z$-boson transverse momentum $p_T$ and rapidity $y$ are measured in the pole region, defined as $80 < m_{\ell\ell} < 100$ GeV, over the range $|y| < 3.6$. The total uncertainty of the normalised cross-section measurements in the peak region of the $p_T$ distribution is dominated by statistical uncertainties over the full range and increases as a function of rapidity from $0.5-1.0$% for $|y| < 2.0$ to $2-7$% at higher rapidities. The results for the rapidity-dependent transverse momentum distributions are compared to state-of-the-art QCD predictions, which combine in the best cases approximate N$^4$LL resummation with N$^3$LO fixed-order perturbative calculations. The differential rapidity distributions integrated over $p_T$ are even more precise, with accuracies from $0.2-0.3$% for $|y| < 2.0$ to $0.4-0.9$% at higher rapidities, and are compared to fixed-order QCD predictions using the most recent parton distribution functions. The agreement between data and predictions is quite good in most cases.