cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
La preservación digital en Colombia: un análisis desde la perspectiva normativa.
Creators: name: Grupo De Investigación Información, Conocimiento Y Sociedad
Publisher: name: figshare
Year: 2020
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences

description: Since 2012, Colombia began the process of implementing digital preservation in archives, based on the publication of policies issued by the Ministry of Culture [Ministerio de Cultura] and the General Archive of the Nation [Archivo General de la Nación]; however, standardized technical criteria, that indicate the use of models or standardized technological tools applied for the preservation of digital documents, are minimal. This is a necessary situation in the social and archival context of the country. Therefore, the current regulations on digital preservation that apply in Colombia to identify archival and technological needs in relation to the research object are identified and analyzed. The results described in this article are presented in the master thesis entitled: “Digital Preservation in Colombia from the Archival Perspective: An Analysis of Policies, Levels of Compliance and a Digital Preservation Scheme for Colombia” [Preservación digital en Colombia desde la perspectiva archivística: análisis de políticas, niveles de cumplimiento y un esquema de preservación digital para Colombia] in order to complete the Master's degree in Gestión Documental, Transparencia y Acceso a la Información of the Autonomous University of Barcelona in 2017.
Desde el año 2012, Colombia inició el proceso de implementación de la preservación digital en los archivos, a partir de la publicación de políticas expedidas por el Ministerio de Cultura y el Archivo General de la Nación; sin embargo, son mínimos los criterios técnicos normalizados que señalen la utilización de modelos o herramientas tecnológicas estandarizadas aplicadas para la preservación de los documentos digitales; situación que es necesaria en el contexto social y archivístico del país. Por lo tanto, se identifican y analizan las normas vigentes sobre preservación digital que aplican en Colombia para determinar las necesidades archivísticas y tecnológicas en relación con el objeto de investigación. Los resultados descritos en este artículo se presentan en virtud de la tesis de fin de máster titulada: Preservación digital en Colombia desde la perspectiva archivística: análisis de políticas, niveles de cumplimiento y un esquema de preservación digital para Colombia, para optar al título de Máster en Gestión Documental, Transparencia y Acceso a la Información de la Universidad Autónoma de Barcelona en el año 2017.
Additional file 5 of Establishment of a novel assessment of the quality of human spermatozoa measuring mitochondrial oxygen metabolism
Creators: name: Taniguchi, Hisanori
name: Matsuo, Yoshiyuki
name: Shimoi, Kayo
name: Yoshimura, Masahiro
name: Hirota, Kiichi
name: Kinoshita, Hidefumi
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Additional file 5: Figure S4. Optimization of the FCCP reagent concentration.
Biologically informed Deep Learning graph-based framework for unveiling critical lncRNAs in CLL
Creators: name: Vasileiou, Vasileios
name: Gavriilidis, George
name: Mraz, Marek
name: Zeni, Pedro
name: Giannakakis, Antonis
name: Pavlopoulos, Georgios
name: Psomopoulos, Fotis
Publisher: name: Zenodo
Year: 2024

description: Transcriptomic analyses elucidate complexities in diseases like Chronic Lymphocytic Leukemia (CLL), revealing specific molecules, cellular traits, and signalling patterns influencing clinical outcomes. The status of the variable region of IGHV in leukemia cells is crucial for classifying CLL cases, providing insights into their clinical condition and prognosis. Patients can be stratified based on the mutational status of the IGHV genes, with mutated CLL (M-CLL) exhibiting a more indolent course than the more aggressive unmutated CLL (U-CLL) cases. Long non-coding RNAs (lncRNAs) play diverse roles in cancer but are often overlooked due to limitations in computational approaches. To address this, we propose a biologically informed Deep Learning model-based framework for supervised patient classification, instructed by lncRNA-mRNA-pathways interactions with eXplainable Artificial Intelligence (XAI) read-outs. This pipeline utilizes NetBID2 for network-based integration of omics data, and PASNet for the deep learning analysis, further building on lncrnalyzer and EnrichR knowledge graphs as input for the biological priors. Complementing these, we deploy custom code integrating SHAP and heatmaps for interpretability, by combining a bespoke graph architecture representing lncRNA-mRNA-pathway interactions, facilitating a comprehensive analysis of regulatory mechanisms. The proposed framework is being tested by applying it into two extensive CLL transcriptomic datasets; data from ICGC-CLLES project (257 samples) are used as the training dataset, with the produced model validated on the BloodCancerMultiOmics2017 dataset (113 samples). Preliminary results showed that U-CLL cases are easily differentiated from M-CLL cases as expected, additionally revealing both biological ground-truth pathways, as well as insofar unknown but potential prognostic lncRNAs in disease.
Quarkonium suppression in heavy-ion collisions: an open quantum system approach
Creators: name: Brambilla, Nora
name: Escobedo, Miguel A.
name: Soto, Joan
name: Vairo, Antonio
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We address the evolution of heavy-quarkonium states in an expanding quark-gluon plasma by implementing effective field theory techniques in the framework of open quantum systems. In this setting we compute the nuclear modification factors for quarkonia that are $S$-wave Coulombic bound states in a strongly-coupled quark-gluon plasma. The calculation is performed at an accuracy that is leading-order in the heavy-quark density expansion and next-to-leading order in the multipole expansion. The quarkonium density-matrix evolution equations can be written in the Lindblad form, and, hence, they account for both dissociation and recombination. Thermal mass shifts, thermal widths and the Lindblad equation itself depend on only two non-perturbative parameters: the heavy-quark momentum diffusion coefficient and its dispersive counterpart. Finally, by numerically solving the Lindblad equation, we provide results for the $Υ(1S)$ and $Υ(2S)$ suppression.
description: 6 pages, 3 figures
Double-Ionization Satellites in the X-ray Emission Spectrum of Ni Metal
Creators: name: Valenza, Ryan A.
name: Jahrman, Evan P.
name: Kas, Joshua J.
name: Seidler, Gerald T.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: We report measurements of the nonresonant x-ray emission spectroscopy (XES) from Ni metal in an energy range spanning the K_beta, valence-to-core, and double-ionization (DI) satellites that appear beyond the single-particle Fermi level. We make special use of a laboratory-based x-ray spectrometer capable of both x-ray emission and x-ray absorption measurements to accurately align the XES and x-ray absorption spectra to a common energy scale. The careful alignment of energy scales is requisite for correction of the strong sample absorption of DI fluorescence above the Ni K-edge energy. The successful correction of absorption effects allows a determination of the branching ratios for the [1s3d], [1s3p], [1s2p] and [1s2s] satellites with respect to their corresponding diagram lines. We compare our results with other work, finding good agreement with prior experiments and with theoretical calculations in the multi-configuration Dirac-Fock framework.
Porcine Colostrum Protects the IPEC-J2 Cells and Piglet Colon Epithelium against Clostridioides (syn. Clostridium) difficile Toxin-Induced Effects
Creators: name: Grześkowiak, Łukasz
name: Pieper, Robert
name: Kröger, Susan
name: Martínez-Vallespín, Beatriz
name: Hauser, Anja E.
name: Niesner, Raluca
name: Vahjen, Wilfried
name: Zentek, Jürgen
Publisher: name: Freie Universität Berlin
Year: 2020
Subjects: subject: Clostridium
subject: Clostridioides difficile
subject: IPEC-J2
subject: Ussing chamber
subject: toxins
subject: colostrum
subject: milk
subject: piglet
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::636 Viehwirtschaft

description: Clostridioides difficile toxins are one of the main causative agents for the clinical symptoms observed during C. difficile infection in piglets. Porcine milk has been shown to strengthen the epithelial barrier function in the piglet’s intestine and may have the potential to neutralise clostridial toxins. We hypothesised that porcine colostrum exerts protective effects against those toxins in the IPEC-J2 cells and in the colon epithelium of healthy piglets. The IPEC-J2 cells were treated with either the toxins or porcine colostrum or their combination. Analyses included measurement of trans-epithelial electrical resistance (TEER), cell viability using propidium iodide by flow cytometry, gene expression of tight junction (TJ) proteins and immune markers, immunofluorescence (IF) histology of the cytoskeleton and a TJ protein assessment. Colon tissue explants from one- and two-week-old suckling piglets and from five-week-old weaned piglets were treated with C. difficile toxins in Ussing chamber assays to assess the permeability to macromolecules (FITC-dextran, HRP), followed by analysis of gene expression of TJ proteins and immune markers. Toxins decreased viability and integrity of IPEC-J2 cells in a time-dependent manner. Porcine colostrum exerted a protective effect against toxins as indicated by TEER and IF in IPEC-J2 cells. Toxins tended to increase paracellular permeability to macromolecules in colon tissues of two-week-old piglets and downregulated gene expression of occludin in colon tissues of five-week-old piglets (p = 0.05). Porcine milk including colostrum, besides other maternal factors, may be one of the important determinants of early immune programming towards protection from C. difficile infections in the offspring.
title: Documentation Needed for Conducting and Reporting on Integrated Ecosystem Assessments
Creators: name: Rice, Jake
name: Zwanenburg, Kees
name: O’boyle, Bob
name: O’brien, Joan
name: Arbour, Joe
name: Perimaki, Liisa
Publisher: name: ASC 2005 - P - Theme session
Year: 2024
Subjects: Technologies and data
Ecosystem observation, processes and dynamics

description: No abstracts are to be cited without prior reference to the author.Implementation of Canada's Ocean Strategy, by the Department of Fisheries and Oceans, features preparation of Ecosystem Overviews and Ecosystem Assessments as core tools for many parts of ocean planning and integrated management. Five different Large Ocean Management Areas have been selected for the initial phase of implementation. Two of these areas - the Eastern Scotian Shelf Integrated Management area and the Gulf of St. Lawrence Integrated Management area - progressed to the stage where documentation for the Overviews and Assessments was reviewed in winter 2005 by DFO Science Branch, under the aegis of the Canadian Science Advisory Secretariat. The review gave particular attention to both the usefulness and the soundness of the documentation.
title: Effectiveness of ultrasonography and nerve conduction studies in the diagnosing of carpal tunnel syndrome: clinical trial on accuracy
Creators: name: Rabay Pimentel, Benedito Felipe
name: Faloppa, Flavio
name: Tamaoki, Marcel
name: Belloti, João Carlos
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: carpal tunnel syndrome
subject: diagnostic accuracy
subject: diagnostic practices
subject: clinical diagnosis
subject: surgical treatment
subject: ultrasonography
subject: ultrasound
subject: nerve conduction studies
subject: electrodiagnostic testing
subject: electromyograph
subject: 610 Medical sciences; Medicine

description: Objectives: The aim of this study was to evaluate the effectiveness of two diagnostic tests routinely used for diagnosing carpal tunnel syndrome, ultrasonography and nerve conduction studies by comparing their accuracy based on surgical results, with the remission of paresthesia as the reference standard.[for full text, please go to the a.m. URL]
description: 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT)
A Survey of Active Attacks on Wireless Sensor Networks and their Countermeasures
Creators: name: Shahzad, Furrakh
name: Pasha, Maruf
name: Ahmad, Arslan
Publisher: name: arXiv
Year: 2017
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences

description: Lately, Wireless Sensor Networks (WSNs) have become an emerging technology and can be utilized in some crucial circumstances like battlegrounds, commercial applications, habitat observing, buildings, smart homes, traffic surveillance and other different places. One of the foremost difficulties that WSN faces nowadays is protection from serious attacks. While organizing the sensor nodes in an abandoned environment makes network systems helpless against an assortment of strong assaults, intrinsic memory and power restrictions of sensor nodes make the traditional security arrangements impractical. The sensing knowledge combined with the wireless communication and processing power makes it lucrative for being abused. The wireless sensor network technology also obtains a big variety of security intimidations. This paper describes four basic security threats and many active attacks on WSN with their possible countermeasures proposed by different research scholars.
title: Development of an Integrated Management Plan for the Eastern Scotian Shelf, Nova Scotia, Canada
Creators: name: Arbour, Joseph
name: Coffen-Smout, Scott
name: Hall, Tim
name: Herbert, Glen
Publisher: name: ASC 2005 - P - Theme session
Year: 2024
Subjects: Technologies and data
Ecosystem observation, processes and dynamics

description: No abstracts are to be cited without prior reference to the author.The Scotian Shelf, located off the east coast of Canada, is an area of intense multiple ocean use that has been identified as one of five priority areas in Canada for the development of Integrated Management Plans under Canada's Oceans Action Plan. It is an area with an historic and productive fishing industry including groundfish, invertebrates and pelagic species. Recently the area has come under development for oil and gas resources. It is also used to route undersea cables and contains important shipping routes for eastern North America. For the eastern portion of this continental margin a planning initiative has been underway since 1998 to implement Integrated Management taking an ecosystem-based approach. The primary building blocks for the plan are science-based ecosystem objectives that are being developed through a dedicated science team drawing on broad multi-stakeholder input. Human use objectives (e.g., socio-economic and institutional) are being developed in parallel and mechanisms are being developed to integrate the ecosystem and human use objectives within the plan. A draft plan was released in February 2005 and is currently being reviewed by stakeholders and government agencies. The draft plan includes 28 ecosystem objectives that focus on biodiversity, productivity and habitat, as well as a series of management strategies and actions to achieve these objectives. This paper describes the evolution of this planning initiative and the approach used in developing and incorporating ecosystem objectives, and the overall collaborative process used in plan development.
title: Diagnosis und therapy of isolated flexor pollicis longus fascicle lesions
Creators: name: Mayer
, Johannes

name: Gohritz, Andreas
name: Salminger, Stefan
name: Bodner, Gerd
name: Friden, Jan
name: Aszmann, Oskar C.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: nerve lesion
subject: reconstruction
subject: AIN
subject: iatrogenic
subject: 610 Medical sciences; Medicine

description: Objectives/Interrogation: Isolated flexor pollicis longus (FPL) nerve fascicle lesion represents a rare differential diagnosis of thumb flexion deficiency. Iatrogenic lesions of the FPL nerve fascicles can occur during operations in the forearm (e.g. osteosynthesis, removal of osteosynthesis material)[for full text, please go to the a.m. URL]
description: 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT)
Multi Agent Driven Data Mining For Knowledge Discovery in Cloud Computing
Creators: name: Jain, Vishal
name: Madan, Mahesh Kumar
Publisher: name: arXiv
Year: 2017
Subjects: subject: Databases (cs.DB)
subject: FOS: Computer and information sciences

description: Today, huge amount of data is available on the web. Now there is a need to convert that data in knowledge which can be useful for different purposes. This paper depicts the use of data mining process, OLAP with the combination of multi agent system to find the knowledge from data in cloud computing. For this, I am also trying to explain one case study of online shopping of one Bakery Shop. May be we can increase the sale of items by using the model, which I am trying to represent.
ELIXIR-Luxembourg – Node activities in training
Creators: name: Codoni, Veronica
name: Popleteeva, Marina
name: Zizovic, Milena
name: Pinar Alper
name: Ded, Vilem
name: Tran, Jenny Thuy Dung
name: Nene Djenaba  Barry
name: Adam, Xavier
name: Krause, Roland
name: Kamlovskaya, Katya
Publisher: name: F1000 Research Limited
Year: 2024

description: Since 2016 Elixir Luxembourg, installed at the Luxembourg Centre for Systems Biomedicine (LCSB), has been steadily expanding its training portfolio, establishing consolidated courses to support the professional development of all-level stage researchers. This growth reflects a commitment to enhance the skills of academic researchers through training programs that are relevant, impactful, and aligned with trends in life science.

Since 2023 Elixir Luxembourg integrated the Luxembourg National Data Service (LNDS) into its node, now encompassing two centres. This strategic enhancement aims to increase the capacity and enable a higher degree of specialisation in its course offerings. The centres aim to deliver training programs that address the needs of diverse audiences, including those in industry and public institutions and to provide a platform for deeper engagement, fostering expertise in key areas and promoting collaboration among researchers.

We present the current node activities, the training landscape in Luxembourg, our interactions with other nodes and our plans for the immediate future.
Additional file 1 of Identifying transferable lessons from cholera epidemic responses by Médecins Sans Frontières in Mozambique, Malawi and the Democratic Republic of Congo, 2015–2018: a scoping review
Creators: name: D’Mello-Guyett, Lauren
name: Cumming, Oliver
name: Rogers, Elliot
name: D’hondt, Rob
name: Mengitsu, Estifanos
name: Mashako, Maria
name: Van den Bergh, Rafael
name: Welo, Placide Okitayemba
name: Maes, Peter
name: Checchi, Francesco
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Preferred Reporting Items for Systematic Reviews and Meta Analyses extension for Scoping Reviews (PRISMA-ScR) checklist.
TRINCO: una estrategia para la transformación de la información en conocimiento con el uso de los SID
Creators: name: Grupo De Investigación Información, Conocimiento Y Sociedad
Publisher: name: figshare
Year: 2020
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences

description: This article presents an instructional strategy theoretically and methodologically founded in order to allow professors, as users of the information, to approach to the documental information systems to teach their higher education students how to use those systems, making easier for them to solve their information needs and transform the information into knowledge. This is the main objective of the Ph.D. dissertation, The Documental Information Systems –DIS– as instructional media: from information to knowledge, and some of its results are shared in this article as well. It is organized from a set of questions answered from the theoretical reflection as what an instructional strategy is and the methodology used for its design; the structure of the instructional strategy TRINCO designed from the methodological reflection is also explained, and final considerations arising after this research work are presented.
Presenta una estrategia didáctica, fundamentada teórica y metodológicamente que permita a los profesores como usuarios de la información acercarse a los sistemas de información documental, para que sean ellos quienes enseñen a los estudiantes de la educación superior a utilizarlos a fin de que les faciliten resolver sus necesidades de información y transformar la información en conocimiento, es el objetivo central de la tesis doctoral denominada Los sistemas de información documental –SID– como medios didácticos: de la información al conocimiento, de la cual se socializan algunos de sus resultados en este artículo. Este se organiza a partir de una serie de preguntas que se responden desde la reflexión teórica, como qué es una estrategia didáctica y la metodología empleada para el diseño de la misma; se explica la estructura de la estrategia didáctica TRINCO que se diseñó desde la reflexión metodológica, y se presentan además las consideraciones finales que surgen luego de esta labor investigativa.
title: Does timing of carpal tunnel release influence the results?
Creators: name: Nemeth, Zoltan
name: Lenkei, Balazs
name: Lakatos, Adrienn
name: Szabo, Zsolt
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: carpal tunnel syndrome
subject: symptomes
subject: timing of operation
subject: results
subject: 610 Medical sciences; Medicine

description: Objectives/Interrogation: In case of carpal tunnel syndrome, the patients' fear of the operation may lead to long lasting symptoms. Our hypothesis was that the longer the patient waits till the operation, the worse the results will be. Methods: We performed a retrospective evaluation [for full text, please go to the a.m. URL]
description: 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT)
Additional file 1 of Physically active primary care doctors are more likely to offer exercise counselling to patients with cardiovascular diseases: a cross-sectional study
Creators: name: Selvaraj, Christine Shamala
name: Abdullah, Nurdiana
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Additional file1: Appendix 1. Fitness Questionnaire. Appendix 2. INTERNATIONAL PHYSICAL ACTIVITY QUESTIONNAIRE.
Presencia de la formación en competencias informacionales (Alfin) en las bibliotecas nacionales iberoamericanas
Creators: name: Grupo De Investigación Información, Conocimiento Y Sociedad
Publisher: name: figshare
Year: 2020
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences

description: We present a characterization of how the Ibero-American National Libraries (inl) are basing their users training approach on the paradigm of Information Literacy (il). With the aim of providing an accurate picture the phenomenon under study, this research employs a mixed methodology combining triangulation of information obtained from documentary analysis of the scientific literature, content analysis of the Websites of libraries and librarians’ viewpoints. In the context of inl, results show that the development of information literacy practice is very new and the cases highlighted correlate with the implementation of specific projects. There is no evidence that il is fundamental and transversal in this type of libraries, or that they serve as a reference for other types of libraries where it operates, despite its “guiding” function in diverse Ibero-American countries. The findings show the need for greater awareness on the part of the National Libraries of the importance of information literacy training of professionals and users which should strive to provide training focused on competence building. Moreover, the study reveals the need to promote the culture of planning, training and evaluation of information literacy and to design appropriate training proposals on the basis of identified areas of improvement.
Se presenta una caracterización de cómo las bibliotecas nacionales iberoamericanas (bni) están asumiendo su función formadora con los usuarios desde el paradigma de la alfabetización informacional (Alfin). Se utiliza una metodología mixta que combina la triangulación de información obtenida a partir del análisis documental de la literatura científica, el análisis de contenido de los sitios web de las bibliotecas y la opinión de los bibliotecarios, con el objetivo de ofrecer una radiografía lo más cercana posible al fenómeno analizado. Los resultados muestran que en el contexto de las bni el desarrollo de las prácticas sobre Alfin es muy incipiente y los casos que destacan son puntuales, con la puesta en marcha de algunos proyectos específicos. No se evidencia que Alfin sea un programa fundamental y transversal para este tipo de bibliotecas ni que sirva de referencia para otras con las que trabaja, teniendo en cuenta su función “rectora” en los diferentes países iberoamericanos. Las conclusiones evidencian, por un lado, la necesidad de una mayor concienciación por parte de las bibliotecas nacionales (bn) acerca de la importancia que tiene la formación en Alfin de profesionales y usuarios, apostando por una mayor capacitación y formación competencial; y, por otro, la necesidad de fomentar la cultura de la planificación, formación y evaluación de Alfin, para diagnosticar áreas de mejora y poder diseñar propuestas formativas adecuadas.
The function and mechanism of dopamine in the activation of CD4+ T cell
Creators: name: Shao, Yu
name: Dong, Yongli
name: Wang, Wenwen
name: Chen, Zhengrong
name: Hao, Chuangli
name: Yang, Yi
name: Zhang, Jinping
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: It has been demonstrated that dopamine (DA) plays an important role in numerous cellular processes of T cell. Accumulating evidence suggests that the outcomes of T cell treatment with DA is depended on DA concentrations, T cell subtypes and activation states. However, the detail mechanism of DA function on T cell activation or regulatory T cells is largely unclear. This study aims to explore the mechanisms by which DA regulates the activation of CD4+ T cells and the function of Tregs. T cell proliferation was detected using CCK-8, BrdU incorporation assay or eFluor 450 cell labeling assay, and Western blot were used to detect phosphorylation of p65 and Erk. Nuclear translocation of transcription factors including p65, FOXO1 and NFAT1 were observed under laser confocal microscopy. Our present study demonstrated that DA (17 µM) can directly promote CD4+ T cells activation through D2-like receptors by enhancing the phosphorylation of p65, also can impair regulatory CD4+ T cells (Tregs) stability and suppressive function through D1- and D2-like receptors by inhibiting the expression of FOXO1 and NFAT1, which are the transcriptional factors of FOXP3, and by suppressing the expression of IL-10 in Tregs. Injection of DA can inhibit tumor growth in vivo. These data indicate a critical role for DA in promotion of CD4+ T helper response, this may applicable in tumor treatment in the future.
title: Concomitant Ipsilateral Endoscopic Carpal and Cubital Tunnel Release: A Single-Center Review of 103 Consecutive Cases
Creators: name: Osterman, Lee
name: Gaspar, Michael
name: Smith, Shelby
name: Osterman, Meredith
name: Kane, Patrick
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Objectives/Interrogation: Endoscopic carpal tunnel release (eCTR) performed in conjunction with endoscopic cubital tunnel release (eCuTR) would have a high rate of success in relieving symptoms related to both carpal and cubital tunnel syndrome, with low rates of complications and revisions. [for full text, please go to the a.m. URL]
description: 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT)
title: Diagnostic Significance of Median Nerve Strain and Applied Pressure Measurement after Carpal Tunnel Release
Creators: name: Yoshii, Yuichi
name: Teramura, Shin
name: Yuine, Hiroshi
name: Ishii, Tomoo
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: median nerve
subject: strain
subject: pressure
subject: carpal tunnel syndrome
subject: ultrasound
subject: 610 Medical sciences; Medicine

description: Objectives/Interrogation: Characterization of the changes of ultrasound parameters after carpal tunnel release may be useful for clarifying recovery process of the carpal tunnel syndrome (CTS) treatment. We hypothesized that the strain and pressure around the median nerve may differ before and [for full text, please go to the a.m. URL]
description: 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT)
Determining reactor fuel type from continuous antineutrino monitoring
Creators: name: Jaffke, Patrick
name: Huber, Patrick
Publisher: name: arXiv
Year: 2016
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We investigate the ability of an antineutrino detector to determine the fuel type of a reactor. A hypothetical 5t antineutrino detector is placed 25m from the core and measures the spectral shape and rate of antineutrinos emitted by fission fragments in the core for a number of 90 day periods. Our results indicate that four major fuel types can be differentiated from the variation of fission fractions over the irradiation time with a true positive probability of detection at 95%. In addition, we demonstrate that antineutrinos can identify the burn-up at which weapons-grade mixed-oxide (MOX) fuel would be reduced to reactor-grade MOX on average, providing assurance that plutonium disposition goals are met. In addition, we investigate removal scenarios where plutonium is purposefully diverted from a mixture of MOX and low-enriched uranium (LEU) fuel. Finally, we discuss how our analysis is impacted by a spectral distortion around 6MeV observed in the antineutrino spectrum measured from commercial power reactors.
description: 6 pages, 3 figures
title: GoMA GOOS: A GOOS Pilot Project in the Gulf of Maine Region
Creators: name: Mountain, D.
name: Harrison, G.
name: Gabriel, W.
name: Gavaris, S.
Publisher: name: ASC 2005 - P - Theme session
Year: 2024
Subjects: Technologies and data
Ecosystem observation, processes and dynamics

description: No abstracts are to be cited without prior reference to the author.A GOOS pilot project in the Gulf of Maine region has been initiated by Fisheries and Oceans Canada and the US National Marine Fisheries Service. The overarching goal of the project is to develop the necessary capabilities and procedures for utilizing the Integrated Ocean Observing System (IOOS) in support of the conservation objectives for an Ecosystem Approach to Fishery Management (EAFM). To that end activities are underway in three areas. The first is identifying the decision requirements for conservation strategies of EAFM and the pertinent indicators that could be derived from ocean observations to support those decisions. The second is working with other ocean data collecting partners to implement the infrastructure for a Gulf of Maine regional IOOS so that the various, relevant data sets can be easily accessed and integrated for analysis. The third activity is initiating directed research efforts to improve the oceanographic and ecological forecast model capabilities in the region. The GoMA GOOS pilot project is scheduled to be conducted over a 5-year period.
The Function and Mechanism of Dopamine in the Activation of CD4+ T Cell
Creators: name: Shao, Yu
name: Dong, Yongli
name: Wang, Wenwen
name: Chen, Zhengrong
name: Hao, Chuangli
name: Yang, Yi
name: Zhang, Jinping
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: It has been demonstrated that dopamine (DA) plays an important role in numerous cellular processes of T cell. Accumulating evidence suggests that the outcomes of T cell treatment with DA is depended on DA concentrations, T cell subtypes and activation states. However, the detail mechanism of DA function on T cell activation or regulatory T cells is largely unclear. This study aims to explore the mechanisms by which dopamine regulates the activation of CD4+ T cells and the function of Tregs. T cell proliferation was detected using CCK-8, BrdU incorporation assay or eFluor 450 cell labelling assay, and Western blot were used to detect phosphorylation of p65 and Erk. Nuclear translocation of transcription factors including p65, FOXO1 and NFAT1 were observed under laser confocal microscopy. Our present study demonstrated that DA (17 μM) can directly promote CD4+ T cells activation through D2-like receptors by enhancing the phosphorylation of p65, also can impair regulatory CD4+ T cells (Tregs) stability and suppressive function through D1- and D2-like receptors by inhibiting the expression of FOXO1 and NFAT1, which are the transcriptional factors of FOXP3, and by suppressing the expression of IL-10 in Tregs. Injection of DA can inhibit tumor growth in vivo. These data indicate a critical role for DA in promotion of CD4+ T helper response, this may applicable in tumor treatment in the future.
Additional file 1 of The behavioural phenotype of SATB2-associated syndrome: a within-group and cross-syndrome analysis
Creators: name: Bissell, Stacey
name: Oliver, Chris
name: Moss, Joanna
name: Heald, Mary
name: Waite, Jane
name: Crawford, Hayley
name: Kothari, Vishakha
name: Rumbellow, Lauren
name: Walters, Grace
name: Richards, Caroline
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. Group characteristics and associated comparative analyses for 18 participants in SAS group who could not be matched for inclusion in cross-syndrome analyses. Post hoc cross-syndrome statistics for AS-autism comparisons. Item-level post hoc comparisons across individual SCQ items (excluding participants under 4 years).
Short Term Power Demand Prediction Using Stochastic Gradient Boosting
Creators: name: Nassif, Ali Bou
Publisher: name: arXiv
Year: 2017
Subjects: subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: Power prediction demand is vital in power system and delivery engineering fields. By efficiently predicting the power demand, we can forecast the total energy to be consumed in a certain city or district. Thus, exact resources required to produce the demand power can be allocated. In this paper, a Stochastic Gradient Boosting (aka Treeboost) model is used to predict the short term power demand for the Emirate of Sharjah in the United Arab Emirates (UAE). Results show that the proposed model gives promising results in comparison to the model used by Sharjah Electricity and Water Authority (SEWA).
La competencia informacional y derechos de autor en las bibliotecas de instituciones de educación superior de Brasil
Creators: name: Grupo De Investigación Información, Conocimiento Y Sociedad
Publisher: name: figshare
Year: 2020
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences

description: Information literacy (IL) is the natural evolution of the old “user training” in libraries, adapted to the new times where technology plays an important role. Legal and ethical use of information is one of the competencies incorporated in important international standards of IL. In order to know the impact of the ethical and legal use of information within these training plans in libraries of higher education entities in Brazil, a brief online questionnaire was designed and executed. The questionnaire aimed to research the existence of plans for IL and/or user training , the ethical and legal use of information, copyright, what kind of information they show, and the availability of staff members at libraries to address concerns on these issues. The results show that libraries of higher education entities in Brazil still have a lot of work to do in our area. Not all of them have adequate education plans for their users and those who do have them, and also include some information about copyright, the discourse focuses on disciplinary aspects, without training authors nor users about their rights, how to use the work of others, how to share their own work, amongst others.
La competencia informacional o alfabetización informacional (COINFO/ALFIN) es la evolución natural de la antigua formación de usuarios en las bibliotecas adaptada a los nuevos tiempos, donde la tecnología juega un importante papel. Por su parte, el uso ético y legal de la información es una de las competencias que conforman este tipo de formación dentro de los estándares internacionales COINFO/ALFIN. Con el objetivo de conocer la repercusión del uso ético y legal de la información dentro de estos planes formativos de las bibliotecas de educación superior en Brasil, se diseñó un breve cuestionario en línea para averiguar si poseen un plan de COINFO o de formación de usuarios, si dentro de los planes se trata el uso ético y legal de la información y los derechos de autor, en qué consiste esta información cuando se produce, y si las bibliotecas disponen de personal preparado para atender dudas sobre estas cuestiones. De los resultados se desprende que las bibliotecas de educación superior en Brasil aún tienen un largo camino por recorrer en materia de COINFO. No todas tienen planes adecuados para sus usuarios y entre los que sí tienen, cuando se habla sobre derechos de autor, el discurso se centra en los aspectos sancionadores de los mismos, sin dar cabida a la formación que permita saber a autores y usuarios qué derechos tienen, cómo usar las obras de terceros o cómo pueden compartir sus obras, entre otros.
title: An analysis of the course of carpal tunnel syndrome before operation
Creators: name: Puchalski, Piotr
name: Zyluk, Andrzej
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: Carpal tunnel syndrome
subject: Natural history
subject: Clinical course
subject: 610 Medical sciences; Medicine

description: Objectives/Interrogation: The natural history of carpal tunnel syndrome (course of untreated disease) is not well recognised. Older studies suggested that CTS progressed in time leading to median nerve compromise and subsequent loss of sensation, muscle weakness and functional impairment. However,[for full text, please go to the a.m. URL]
description: 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT)
Characterizing rare fluctuations in soft particulate flows
Creators: name: Rahbari, S. H. E.
name: Saberi, A. A.
name: Park, H.
name: Vollmer, J.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Soft particulate media include a wide range of systems involving athermal dissipative particles both in non-living and biological materials. Characterization of flows of particulate media is of great practical and theoretical importance. A fascinating feature of these systems is the existence of a critical rigidity transition in the dense regime dominated by highly intermittent fluctuations that severely affects the flow properties. Here, we unveil the underlying mechanisms of rare fluctuations in soft particulate flows. We find that rare fluctuations have different origins above and below the critical jamming density and become suppressed near the jamming transition. We then conjecture a time-independent local fluctuation relation, which we verify numerically, and that gives rise to an effective temperature. We discuss similarities and differences between our proposed effective temperature with the conventional kinetic temperature in the system by means of a universal scaling collapse.
description: 7 pages, 4 figures, to appear in Nature Communications (2017)
title: Recurrent and persistent carpal tunnel syndrome: predicting clinical outcome of revision surgery
Creators: name: Sun, Pepijn
name: Selles, Ruud
name: Jansen, Miguel
name: Slijper, Harm
name: Ulrich, Dietmar
name: Walbeehm, Erik
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: Carpal tunnel syndrome
subject: persistent
subject: recurrent
subject: revision surgery
subject: prediction
subject: Boston carpal tunnel questionnaire
subject: 610 Medical sciences; Medicine

description: Objectives/Interrogation: The aim of this study was to evaluate the outcome of revision surgery in patients with recurrent and persistent carpal tunnel syndrome(CTS) and to identify predictors of clinical outcome of revision surgery. Methods: A total of 114 hands in 112 patients were surgically[for full text, please go to the a.m. URL]
description: 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT)
Galaxy workflow for bacterial genomics exploration and chitin utilization enzyme identification: A case study exploring the Streptomyces albogriseolus PMB5 genome
Creators: name: Baev, Vesselin
name: Iliev, Ivan
name: Gozmanova, Mariyana
name: Apostolova, Elena
name: Yanitsa Ilieva
name: Yahubyan, Galina
name: Gochev, Velizar
Publisher: name: F1000 Research Limited
Year: 2024

description: Numerous symbiotic relationships between bacteria have evolved within the insect's gut. Bacterial mutualists within insect guts play a crucial role in modulating the host's metabolism and enhancing digestion to extract maximum energy from consumed food. Therefore the carnivorous insect hosts can be a valuable natural source of chitinolytic bacterial strains. In this study, we have explored and screened for chitin-degrading bacteria within the gut microbiota of the carnivorous insect Mantis religiosa. For that reason, we conducted whole-genome sequencing using Nanopore technology of the chitinase-producing Streptomyces albogriseolus PMB5 to elucidate the detailed genomic landscape of chitinase repertoire and to explore the genes essential for chitin degradation and their functions using Galaxy platform and a dedicated workflow. Furthermore, our research endeavors contribute significantly to the elucidation of the genomic architecture of Streptomyces albogriseolus, a species that has been underrepresented in scientific investigations. This effort not only expands our comprehension of its genetic landscape but also serves for future studies aiming to explore its potential applications in various fields, such as biotechnology, environmental science, and industry. Moreover, our study adds to the Galaxy workflow community by enriching its repository with a

dedicated workflow, facilitating easier data analysis for fellow researchers.
title: Clinimetrics in hand therapy: construct validity of the copm in participants with tendon injury and Dupuytren disease
Creators: name: van de Ven-Stevens, Lucelle
name: Graff, Maud
name: Geurts, Alexander
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: COPM
subject: outcome
subject: hand conditions hand injuries
subject: validity
subject: MHQ
subject: DASH
subject: clinimetrics
subject: 610 Medical sciences; Medicine

description: Background: In patient-centered practice instruments need to assess outcomes that are meaningful to patients with hand conditions. Clinical reasoning: The aim of this study was to establish the construct validity of the COPM in people with hand conditions. It was hypothesized that COPM scores would[for full text, please go to the a.m. URL]
description: 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT)