cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Sex difference in cerebrospinal fluid/blood albumin quotients in patients with schizophreniform and affective psychosis
Creators: name: Meixensberger, Sophie
name: Bechter, Karl
name: Dersch, Rick
name: Feige, Bernd
name: Maier, Simon
name: Schiele, Miriam A.
name: Runge, Kimon
name: Denzel, Dominik
name: Nickel, Kathrin
name: Spieler, Derek
name: Urbach, Horst
name: Prüss, Harald
name: Domschke, Katharina
name: Tebartz Van Elst, Ludger
name: Endres, Dominique
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Cerebrospinal fluid
subject: Albumin quotient
subject: Protein
subject: Psychosis
subject: Sex
subject: DDC 150 / Psychology
subject: DDC 610 / Medicine & health

description: Abstract Background The importance of cerebrospinal fluid (CSF) diagnostics for psychiatry is growing. The CSF/blood albumin quotient (QAlb) is considered to be a measure of the blood–CSF barrier function. Recently, systematically higher QAlb in males than in females was described in neurological patients. The aim of this study was to investigate whether a sex difference could also be detected in a well-characterized psychiatric cohort. Methods The patient cohort comprised 989 patients, including 545 females and 444 males with schizophreniform and affective syndromes who underwent CSF diagnostics, including QAlb measurement. The basic CSF findings and antineuronal autoantibody data of this cohort have already been published. This re-analysis employed analysis of covariance with age correction for QAlb mean values and chi2-testing for the number of increased age-corrected QAlb levels to investigate sex differences in QAlb. Results The QAlb levels were elevated above reference levels by 18% across all patients, and a comparison between male and female patients revealed a statistically significant sex difference, with increased values in 26% of male patients and a corresponding rate of only 10% in female patients (chi2 = 42.625, p < 0.001). The mean QAlb values were also significantly higher in males (6.52 ± 3.69 × 10–3) than in females (5.23 ± 2.56 × 10–3; F = 52.837, p < 0.001). Discussion The main finding of this study was a significantly higher QAlb level in male compared to female patients with psychiatric disorders, complementing previously described sex differences in neurological patient cohorts. This result indicates bias from some general factors associated with sex and could be partly explained by sex differences in body height, which is associated with spine length and thus a longer distance for CSF flow within the subarachnoid space down the spine from the occipital area to the lumbar puncture site in males compared to females. Hormonal influences caused by different estrogen levels and other sex-specific factors could also play a relevant role. The significance of the study is limited by its retrospective design, absence of a healthy control group, and unavailability of exact measures of spine length.
Additional file 6 of Cross-tissue and generation predictability of relative Wolbachia densities in the mosquito Aedes aegypti
Creators: name: Mejia, Austin J.
name: Dutra, H. L. C.
name: Jones, M. J.
name: Perera, R.
name: McGraw, E. A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Zoology

description: Additional file 6: Figure S6. Crossing point values of rps17 in the eggs of mothers (P1) and tissues of daughters (F1). These data pertain to Fig. 7 in the main text. For P1 eggs n = 20 individuals, while for ovaries and carcass n = 94 individuals. Bars indicate tissue means ± SE. ns, Not significant; asterisks indicate significant difference at ****P ≤ 0.0001.
A beaker burial in Levens Park.
Creators: name: Turnbull, Percival
name: Walsh, Deborah
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 96, 13-26
description: Excavation between 1968 and 1971 in Levens medieval deer-park uncovered a Beaker burial ring cairn site including two Beakers, four burials, and flint knives. It is thought, on balance, to exhibit most affinity with Scottish and north-eastern sites rather than Yorkshire and the rest of England. Also in evidence were a pre-medieval field-system, and a sub-rectangular enclosure (possibly an early church site, stripped to reveal Roman deposits).
Additional file 1 of The smoothened agonist SAG reduces mitochondrial dysfunction and neurotoxicity of frataxin-deficient astrocytes
Creators: name: Vicente-Acosta, Andrés
name: Giménez-Cassina, Alfredo
name: Díaz-Nido, Javier
name: Loria, Frida
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1. Table S1. Human primer sequences used for qPCR. Table S2. Statistical analysis of the pan, A1 and A2 reactive marker transcripts analyzed by qPCR. Values represent the mean ± S.E.M. from four biologically independent experiments. One-way ANOVA followed by Tukey's post hoc test or a 1-sample t-test were used to test for statistical significance. n.s, not significant. Figure S1. MTS quantification of neuronal metabolic activity upon addition of ACM. For these experiments, cortical neurons were cultured for 5 days (120 h) in ACM from HAs cultured under standard conditions (untreated) or transduced with either the LV-scrambled or LV-shRNA37, treated daily or not with SAG at 1 μM.
Recent archaeological fieldwork in the Howgill Fells by the Royal Commission on the Historical Monuments of England.
Creators: name: Bowden, Mark
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 96, 1-12
description: A dearth of NMR records prompted this 1993 and 1994 survey of the Howgill Fells with Dentdale and part of Barbondale. Aerial photography records from 1992 were also utilised. Sites were few -- possibly a result of present day occupation mirroring that from prehistoric to medieval and post-medieval. The second phase of the endeavour surveyed a variety of settlements, shielings, and enclosures at twelve separate sites. Eighty NMR records have been enhanced as a result of this work and 115 sites have been added to the NMR.
The spectrum and differential diagnosis of acquired ocular motor nerve palsies : a clinical study of 502 patients
Creators: name: Hörner, Rebecca
name: Kassubek, Jan
name: Dreyhaupt, Jens
name: Ludolph, Albert C.
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Cranial nerve palsy
subject: Ocular motor nerve
subject: DDC 610 / Medicine & health
subject: Cranial nerve diseases
subject: Trochlear nerve
subject: Abducens nerve
subject: Magnetic resonance imaging
subject: Cerebrospinal fluid
subject: Hirnnervenkrankheit
subject: Abduzenslähmung
subject: Kernspintomografie
subject: Liquor cerebrospinalis

description: Background Ocular motor nerve palsies (OMNP) frequently cause patients to present in an emergency room. In the following study, we report the differential diagnosis of OMNP by use of magnetic resonance imaging (MRI) and CSF examination as a standard. Method We performed a data analysis of N = 502 patients who presented with oculomotor, trochlear, and/or abducens nerve palsy in the emergency room of the Department of Neurology, University of Ulm, between January 2006 and December 2019. We report clinical and MRI scan findings in all patients; furthermore, the CSF of 398 patients has been analysed. Results Abducens nerve palsies were most common (45%), followed by palsies of the oculomotor (31%) (CNP III) and trochlear nerve (15%). Multiple OMNPs were seen in 9% of our cohort. The most common causes included inflammations (32.7%), space-occupying lesions, such as aneurysms or neoplasms (17.3%), diabetes mellitus (13.3%), and brainstem infarctions (11%). Still 23.4% of the patients could not be assigned to any specific cause after differential diagnostic procedures and were described as idiopathic. One of three patients with an inflammation and 39% of the patients with space-occupying lesions showed additional cranial nerve deficits. Conclusion Inflammation and space-occupying processes were the most frequent causes of OMNP, although brainstem infarctions also play a significant role, in particular in CNP III. The presence of additional CNPs increases the probability of an inflammatory or space-occupying cause.
Supplemental figures, tables, and discussion to accompany “Handicap principle implies emergence of dimorphic ornaments”
Creators: name: Clifton, Sara M.
name: Braun, Rosemary I.
name: Abrams, Daniel M.
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: 10202 Biological Mathematics
subject: FOS: Mathematics

description: 8 supplemental figures, 2 supplemental tables, and 11 supplemental sections to accompany "Handicap principle implies emergence of dimorphic ornaments"; Figure S1: Probability density function; Figure S2: Example potential functions; Figure S3: Perturbation calculation; Figure S4: Comparison of Hartigans' dip test and our bootstrap dip test; Figure S5: Additional ornament data sets (birds); Figure S6: Additional ornament data sets; Figure S7: Bimodal body size data sets; Figure S8: Bimodal forest data sets; Table I: Dip test results; Table II: Gaussian mixture model fit results; Section I: The connection between potential and fitness; Section II: Fixed points for general class of potential functions with minimum of 2 morphs; Section III: Fixed points for general class of potential functions with maximum of 2 morphs; Section IV: Continuum limit; Section V: Eigenvalues of system as N to infinity; Section VI: Alternative multiplicative form for potential; Section VII: Mechanisms for bimodality; Section VIII: Applicability of model; Section IX:; Statistical analysis of ornamentation data; Section X: Additional Data and Analysis; Section XI: Connection to speciation models
Additional file 7 of Cross-tissue and generation predictability of relative Wolbachia densities in the mosquito Aedes aegypti
Creators: name: Mejia, Austin J.
name: Dutra, H. L. C.
name: Jones, M. J.
name: Perera, R.
name: McGraw, E. A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Zoology

description: Additional file 7: Figure S7. Relative Wolbachia densities (ankyrin repeat domain to rps17) in the ovaries and the carcass of Ae. aegypti in the same generation of daughters (F1). n = 79, P = 0.21 (paired t-test). Bars indicate tissue means ± SE. ns, Not significant.
Chronon Wave Time Theory
Creators: name: Monroe, Scott
Publisher: name: Zenodo
Year: 2025

description: Chronon Wake Time Theory proposes that time is not a built-in dimension of the universe, but rather an emergent effect generated by the movement of photons. According to this framework, light does not travel through time — it creates time in its wake. As photons propagate through space, they leave behind discrete, ripple-like disturbances called chronons. These chronons are not particles or waves in the traditional sense, but quantized shifts in the causal structure of spacetime. Massive observers, unable to travel at light speed, lag behind these causal crests and accumulate chronons along their paths, which gives rise to the experience of time.

This theory reinterprets time as a phase lag relative to light's motion, rather than as a universal backdrop. It aligns with key principles of special relativity, such as the fact that photons experience no proper time, and extends into general relativity by allowing the causal wake structure to evolve in curved spacetime. It also connects naturally to quantum gravity approaches like causal set theory and loop quantum gravity by offering a discrete, observer-relative account of temporal evolution. Rather than treating time as a preexisting axis, the model treats it as a geometric consequence of causal separation from light.

Chronon Wake Time Theory offers a novel lens through which to unify discrete and continuous models of physics, and may provide insight into the origin of the arrow of time, quantum measurement timing, and even the large-scale structure of cosmological time. While conceptual in nature, it leads to testable implications, such as temporal granularity in quantum systems and phase-linked coherence effects. The framework opens a pathway toward reframing time as a product of causality — not chronology — and offers a powerful foundation for exploring the geometry of emergent temporal structure in both theoretical and experimental contexts.
Pathogen-associated selection on innate immunity genes (TLR4, TLR7) in a neotropical rodent in landscapes differing in anthropogenic disturbance
Creators: name: Heni, Alexander Christoph
name: Schmid, Julia
name: Rasche, Andrea
name: Corman, Victor Max
name: Drosten, Christian
name: Sommer, Simone
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: DDC 570 / Life sciences
subject: Ecological genetics
subject: Immunogenetics
subject: Immungenetik

description: Toll-like receptors (TLRs) form part of the innate immune system and can recognize structurally conserved pathogen-associated molecular pattern (PAMP) molecules. Their functional importance in the resistance to pathogens has been documented in laboratory experimental settings and in humans. TLR diversity, however, has been rarely investigated in wildlife species. How the genetic diversity of TLRs is associated with various pathogens and how it is shaped by habitat disturbance are understudied. Therefore, we investigated the role of genetic diversity in the functionally important parts of TLR4 and TLR7 genes in resistance towards gastrointestinal nematodes and Hepacivirus infection. We chose a generalist study species, the rodent Proechimys semispinosus, because it is highly abundant in three Panamanian landscapes that differ in their degree of anthropogenic modification. We detected only two TLR7 haplotypes that differed by one synonymous single-nucleotide polymorphism (SNP) position. The TLR4 variability was higher, and we detected four TLR4 haplotypes that differed at one synonymous SNP and at three amino acid positions within the leucine-rich repeat region. Only TLR4 haplotypes had different frequencies in each landscape. Using generalized linear models, we found evidence that nematode loads and virus prevalence were influenced by both specific TLR4 haplotypes and landscape. Here, the variable “landscape” served as a surrogate for the important influential ecological factors distinguishing landscapes in our study, i.e. species diversity and host population density. Individuals carrying the common TLR4_Ht1 haplotype were less intensely infected by the most abundant strongyle nematode. Individuals carrying the rare TLR4_Ht3 haplotype were all Hepacivirus-positive, where those carrying the rare haplotype TLR4_Ht4 were less often infected by Hepacivirus than individuals with other haplotypes. Our study highlights the role of TLR diversity in pathogen resistance and the importance of considering immune genetic as well as ecological factors in order to understand the effects of anthropogenic changes on wildlife health.
Cryo-balloon catheter localization in X-Ray fluoroscopy using U-net
Creators: name: Vernikouskaya, Ina
name: Bertsche, Dagmar
name: Dahme, Tillman
name: Rasche, Volker
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Cryo-balloon
subject: Automatic segmentation
subject: Reconstruction
subject: Semi-automatic annotation
subject: Unet
subject: DDC 610 / Medicine & health
subject: DDC 620 / Engineering & allied operations

description: Abstract Purpose Automatic identification of interventional devices in X-ray (XR) fluoroscopy offers the potential of improved navigation during transcatheter endovascular procedures. This paper presents a prototype implementation of fully automatic 3D reconstruction of a cryo-balloon catheter during pulmonary vein isolation (PVI) procedures by deep learning approaches. Methods We employ convolutional neural networks (CNN) to automatically identify the cryo-balloon XR marker and catheter shaft in 2D fluoroscopy during PVI. Training data are generated exploiting established semiautomatic techniques, including template-matching and analytical graph building. A first network of U-net architecture uses a single grayscale XR image as input and yields the mask of the XR marker. A second network of the similar architecture is trained using the mask of the XR marker as additional input to the grayscale XR image for the segmentation of the cryo-balloon catheter shaft mask. The structures automatically identified in two 2D images with different angulations are then used to reconstruct the cryo-balloon in 3D. Results Automatic identification of the XR marker was successful in 78% of test cases and in 100% for the catheter shaft. Training of the model for prediction of the XR marker mask was successful with 3426 training samples. Incorporation of the XR marker mask as additional input for the model predicting the catheter shaft allowed to achieve good training result with only 805 training samples. The average prediction time per frame was 14.47 ms for the XR marker and 78.22 ms for the catheter shaft. Localization accuracy for the XR marker yielded on average 1.52 pixels or 0.56 mm. Conclusions In this paper, we report a novel method for automatic detection and 3D reconstruction of the cryo-balloon catheter shaft and marker from 2D fluoroscopic images. Initial evaluation yields promising results thus indicating the high potential of CNNs as alternatives to the current state-of-the-art solutions.
Additional file 8 of Cross-tissue and generation predictability of relative Wolbachia densities in the mosquito Aedes aegypti
Creators: name: Mejia, Austin J.
name: Dutra, H. L. C.
name: Jones, M. J.
name: Perera, R.
name: McGraw, E. A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Zoology

description: Additional file 8: Figure S8. Relationship between relative Wolbachia densities in the ovaries and the carcass of Ae. aegypti in the same generation of daughters (F1). n = 79.
Habit formation in context : context-specific and context-free measures for tracking fruit consumption habit formation and behaviour
Creators: name: Diefenbacher, Svenne
name: Lally, Philippa
name: Gardner, Benjamin
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: automaticity
subject: behaviour change
subject: fruit consumption
subject: habit formation
subject: health behaviour
subject: prospective study
subject: DDC 150 / Psychology
subject: Behavior modification
subject: Habit
subject: Measurement
subject: Health behavior
subject: Automatism; Psychology
subject: Unconscious, Psychology
subject: Verhaltensmodifikation
subject: Automatismus
subject: Gesundheitsverhalten
subject: Messung

description: Objectives Interventions promoting habitual fruit consumption have the potential to bring about long-term behaviour change. Assessing the effectiveness of such interventions requires adequate habit and behaviour measures. Habits are based on learned context-behaviour associations, so measures that incorporate context should be more sensitive to expected habit and behaviour changes than context-free measures. This study compared context-specific and context-free measures of fruit consumption habit and behaviour following a 3-week habit formation intervention. Design Prospective online study (n = 58). Methods Behaviour frequency was assessed across five timepoints, retrospectively (Time 1 [T1], T5) or via daily diary data (uploaded weekly at T2, T3 and T4). Habit strength was assessed before (T1) and immediately after the intervention (T4), and again 2 weeks later (T5). Analyses of variance were run, with time and context specificity as within-subject factors, and habit and behaviour frequency as dependent measures. Results An interaction between time and context specificity was found in both analyses (habit: F(2,114) = 12.848, p < .001, part.η2 = .184; behaviour: F(2,114) = 6.714, p = .002, part.η2 = .105). Expected habit formation patterns 5 weeks post-baseline were only detected by the context-specific habit measure. Likewise, increased behaviour frequency was only found when the target context was specified (p's < .001). Conclusions Assessments of purposeful dietary habit and behaviour change attempts should incorporate context-specific measurement.
Patient satisfaction & use of health care: a cross-sectional study of asylum seekers in the Freiburg initial reception centre
Creators: name: Bockey, Annabelle J.
name: Janda, Aleš
name: Braun, Cornelia
name: Müller, Anne-Maria
name: Stete, Katarina
name: Kern, Winfried V.
name: Rieg, Siegbert R.
name: Lange, Berit
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Delivery of health care
subject: Patient satisfaction
subject: Refugees & Asylum Seekers
subject: Germany
subject: DDC 610 / Medicine & health

description: Abstract Background In response to a high number of incoming asylum seekers and refugees (AS&R) in Germany, initial reception centres were established to provide immediate shelter, food and health support. This study evaluates the satisfaction with and use of the health care available at the Freiburg initial reception centre (FIRC) where an integrated health care facility (ICF) was set up in 2015. Methods We assessed use and satisfaction with health services available to resident AS&R within and outside the FIRC in a cross-sectional design. Data were collected in 2017 using a questionnaire with both open and closed ended items. Results The majority of 102 included participants were young (mean age 24.2; 95%CI 22.9–25.5, range 18–43) males (93%), from Sub-Saharan Africa (92%). High use frequencies were reported from returning patients of the ICF; with 56% fortnightly use and 19% daily use reported. The summary of satisfaction scores indicated that 84% (CI95 76–89%) of respondents were satisfied with the ICF. Multivariate analysis showed female gender and non-English speaking as risk factors for low satisfaction. Outside the FIRC, the satisfaction scores indicated that 60% of participants (95%CI 50–69%) were satisfied with the health care received. Conclusion Our study shows that AS&R residing in the FIRC are generally satisfied with the services at the ICF, though strategies to enhance care for females and non-English speakers should be implemented. Satisfaction with health care outside of the FIRC was not as high, indicating the need to improve quality of care and linkage to regular health care services.
AN ANALYSIS ON JARGON USED IN INDONESIA LAWAK KLUB (ILK) PROGRAM ON TRANS 7
Creators: name: Astutik, Yuli
Publisher: name: figshare
Year: 2016
Subjects: subject: Linguistics
subject: FOS: Languages and literature

description: This research aims to analyze the jargon used in Indonesia Lawak Klub (ILK) program on Trans 7. The problems formulated are: 1) What are the jargons and types of jargon used in Indonesia Lawak Klub (ILK) program on Trans 7?, 2) What is the dominant type of jargon used in Indonesia Lawak Klub (ILK) program on Trans 7?. The method used in this research was descriptive qualitative design. In applying this method, the writer used the technique of observation because the writer wanted to pay attention, watch and listen carefully to the sources of the data. The writer also observed the conversation that occurred among the entertainers in ILK program by using video and tape recorder. After conducted the observation on the date of 12, 13 and 20 of October 2015, the result showed that there were 37 (100%) jargons used by the comedians and the guest in ILK program on Trans 7 when they talked with each other. Then, there were three types of jargon used in this program such as 24 (64, 86%) abbreviations, 11 (29, 72%) deviation words and 2 (5, 4%) deviation names. The most dominant type of jargon used in Indonesia Lawak Klub (ILK) program was abbreviation.
Criminal victimization, cognitive social capital and mental health in an urban region in Germany : a path analysis
Creators: name: Kilian, Reinhold
name: Müller-Stierlin, Annabel Sandra
name: Lamp, Natalie
name: Von Gottberg, Carolin
name: Becker, Thomas
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Criminal victimization
subject: Cognitive social capital
subject: DDC 150 / Psychology
subject: DDC 610 / Medicine & health
subject: Victims of crimes
subject: Crime victims
subject: Mental health
subject: Depression
subject: Anxiety
subject: Viktimisierung
subject: Verbrechensopfer
subject: Psychische Gesundheit
subject: Angst
subject: Depression

description: Purpose There is ample evidence that experiencing a criminal victimization is associated with lasting emotional problems among victims. To date, the mechanisms behind this association are not well understood. Based on the theoretical assumptions derived from a transactional stress-appraisal and coping model this study analyses the role of cognitive social capital (SC) in the association between criminal victimization (CV) and victims’ mental health. Methods A cross-sectional, computer-aided telephone survey including a representative sample of 3005 persons from three German cities was conducted. Respondents were asked about CV during their lifetime, cognitive SC, perceived victimization risk, perceived safety and perceived ability to prevent victimization. The PHQ-4 was used as a measure of anxiety and depression. The data were analyzed by means of logistic regression models and a path model controlled for sociodemographic characteristics. Results Lifetime CV with any type of crime was associated with a clinically relevant increased risk of mental disorder (PHQ-4 ≥ 9; OR 1.8, p ≤ 0.05). Path analyses revealed that the direct association between CV and PHQ-4 (β = 0.454; p ≤ 0.01) was significantly diminished by cognitive SC (β =  − 0.373; p ≤ 0.05). Conclusion Our results suggest that cognitive SC is an individual resilience factor against negative experiences related to CV and that it holds the potential to diminish negative mental health consequences of CV. Further research should explore to what extent an enhancement of cognitive SC can help to prevent anxiety and depression among crime victims.
Vertical root fracture resistance and crack formation of root canal-treated teeth restored with different post-luting systems
Creators: name: Rathke, Andreas
name: Frehse, Henry
name: Hrusa, Beatrice
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Dentin crack
subject: Fiber-reinforced composite
subject: Post
subject: Staircase
subject: Vertical root fracture
subject: DDC 610 / Medicine & health
subject: Fibrous composites
subject: Staircases
subject: Treppe

description: The aim was to investigate the vertical root fracture (VRF) resistance and crack formation of root canal-treated teeth restored with different post-luting systems. Human maxillary lateral incisors of similar size were decoronated, assigned to five groups (n = 18, power = 0.9) and embedded in acrylic blocks with artificial periodontal ligament. After root canal filling, post spaces were prepared to place coated fiber-reinforced composite (FRC) or sandblasted titanium (Ti) posts of the same shape and size. Half of the posts were zinc phosphate cemented (C), while the other half was adhesively luted (A). Untreated teeth served as control. After thermal cycling and staircase loading in a chewing simulator, the crack formation on the root dentin surface was microscopically examined and classified as no defect, craze line, vertical crack, and horizontal crack. Subsequently, the samples were loaded until root fracture. Data were analyzed by one-way ANOVA, Tukey’s test, and Fisher’s exact test. All samples survived the chewing simulation without VRF, but crack formation was significantly different between the groups (P = 0.009). The control showed significantly fewer defects than FRC/C, Ti/C, and Ti/A (P = 0.001, P = 0.008, P = 0.008, respectively). FRC/C showed the highest incidence of vertical cracks. FRC/A had the lowest incidence of defects. There was no significant difference in VRF resistance between the groups (P = 0.265). Adhesively luted FRC posts did not increase VRF resistance but reduced the risk of defects. Most defects were craze lines and vertical root cracks.
Classifier‐Guided Visual Correction of Noisy Labels for Image Classification Tasks
Creators: name: Bäuerle, Alex
name: Neumann, Heiko
name: Ropinski, Timo
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: CCS Concepts
subject: DDC 004 / Data processing & computer science
subject: Machine learning
subject: Expert systems
subject: Human-computer interaction
subject: User-centered system design
subject: Information visualization
subject: Maschinelles Lernen
subject: Expertensystem
subject: Mensch-Maschine-Kommunikation

description: Training data plays an essential role in modern applications of machine learning. However, gathering labeled training data is time-consuming. Therefore, labeling is often outsourced to less experienced users, or completely automated. This can introduce errors, which compromise valuable training data, and lead to suboptimal training results. We thus propose a novel approach that uses the power of pretrained classifiers to visually guide users to noisy labels, and let them interactively check error candidates, to iteratively improve the training data set. To systematically investigate training data, we propose a categorization of labeling errors into three different types, based on an analysis of potential pitfalls in label acquisition processes. For each of these types, we present approaches to detect, reason about, and resolve error candidates, as we propose measures and visual guidance techniques to support machine learning users. Our approach has been used to spot errors in well-known machine learning benchmark data sets, and we tested its usability during a user evaluation. While initially developed for images, the techniques presented in this paper are independent of the classification algorithm, and can also be extended to many other types of training data.
title: OFROM: interview avec unine15a89d
Creators: name: Delafontaine, François
name: Rothenbühler, Julie
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.a9c66239.v2#d8480239f54812730d0c0fc89f6117d7d95300c5
Additional file 1 of Teaching design thinking as a tool to address complex public health challenges in public health students: a case study
Creators: name: Ingram, Carolyn
name: Langhans, Tessa
name: Perrotta, Carla
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1.
Short-term metreleptin treatment of patients with anorexia nervosa: rapid on-set of beneficial cognitive, emotional, and behavioral effects
Creators: name: Milos, Gabriella
name: Antel, Jochen
name: Kaufmann, Lisa-Katrin
name: Barth, Nikolaus
name: Koller, Antonia
name: Tan, Susanne
name: Wiesing, Urban
name: Hinney, Anke
name: Libuda, Lars
name: Wabitsch, Martin
name: Von Känel, Roland
name: Hebebrand, Johannes
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Psychiatric disorders
subject: Scientific community
subject: DDC 610 / Medicine & health

description: Abstract To examine the hypothesis that normalization of low circulating leptin levels in patients with anorexia nervosa ameliorates hyperactivity, three seriously ill females with hyperactivity were treated off-label with metreleptin (recombinant human leptin) for up to 14 days. Drive for activity, repetitive thoughts of food, inner restlessness, and weight phobia decreased in two patients. Surprisingly, depression improved rapidly in all patients. No serious adverse events occurred. Due to obvious limitations of uncontrolled case series, placebo-controlled clinical trials are mandatory to confirm the observed rapid onset of beneficial effects. Our findings suggest an important role of hypoleptinemia in the mental and behavioral phenotype of anorexia nervosa.
CCND3 is indispensable for the maintenance of B-cell acute lymphoblastic leukemia
Creators: name: Ketzer, Franz
name: Abdelrasoul, Hend
name: Vogel, Mona
name: Marienfeld, Ralf
name: Müschen, Markus
name: Jumaa, Hassan
name: Wirth, Thomas
name: Ushmorov, Alexey
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Leukaemia
subject: FOXO1
subject: MYC
subject: Kinase
subject: DDC 610 / Medicine & health
subject: Cancer
subject: Leukemia
subject: Neoplasms
subject: Cell division
subject: Cyclin D3
subject: Forkhead transcription factors
subject: Phosphotransferases
subject: Krebs
subject: Leukämie
subject: Zellteilung
subject: Forkhead-Box-Proteine

description: The D-type cyclins (CCND1, CCND2, and CCND3) in association with CDK4/6 are known drivers of cell cycle progression. We reported previously that inactivation of FOXO1 confers growth arrest and apoptosis in B-ALL, partially mediated by subsequent depletion of CCND3. Given that previously the canonical MYC target CCND2 has been considered to play the major role in B-ALL proliferation, further investigation of the role of FOXO1 in CCND3 transcription and the role of CCND3 in B-ALL is warranted. In this study, we demonstrated that CCND3 is essential for the proliferation and survival of B-ALL, independent of the mutational background. Respectively, its expression at mRNA level exceeds that of CCND1 and CCND2. Furthermore, we identified FOXO1 as a CCND3-activating transcription factor in B-ALL. By comparing the effects of CCND3 depletion and CDK4/6 inhibition by palbociclib on B-ALL cells harboring different driver mutations, we found that the anti-apoptotic effect of CCND3 is independent of the kinase activity of the CCND3-CDK4/6 complex. Moreover, we found that CCND3 contributes to CDK8 transcription, which in part might explain the anti-apoptotic effect of CCND3. Finally, we found that increased CCND3 expression is associated with the development of resistance to palbociclib. We conclude that CCND3 plays an essential role in the maintenance of B-ALL, regardless of the underlying driver mutation. Moreover, downregulation of CCND3 expression might be superior to inhibition of CDK4/6 kinase activity in terms of B-ALL treatment.
A watching brief at 46-52 Lowther Street, Carlisle.
Creators: name: Flynn, Paul
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 95, 278-282
description: Reprint of an article from the previous edition of the journal to include previously omitted figures (also featured as 97/531).
Linear/Ridge expansions : enhancing linear approximations by ridge functions
Creators: name: Greif, Constantin
name: Junk, Philipp
name: Urban, Karsten
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Linear approximation
subject: Ridge functions
subject: Particle grid algorithm
subject: Nonlinear model reduction
subject: DDC 510 / Mathematics
subject: Wave functions
subject: Nichtlineare modellprädiktive Regelung

description: We consider approximations formed by the sum of a linear combination of given functions enhanced by ridge functions—a Linear/Ridge expansion. For an explicitly or implicitly given objective function, we reformulate finding a best Linear/Ridge expansion in terms of an optimization problem. We introduce a particle grid algorithm for its solution. Several numerical results underline the flexibility, robustness and efficiency of the algorithm. One particular source of motivation is model reduction of parameterized transport or wave equations. We show that the particle grid algorithm is able to find a Linear/Ridge expansion as an efficient nonlinear model reduction.
Additional file 1 of Transparency in quality of radiotherapy for breast cancer in the Netherlands: a national registration of radiotherapy-parameters
Creators: name: Maliko, Nansi
name: Stam, Marcel R.
name: Boersma, Liesbeth J.
name: Vrancken Peeters, Marie-Jeanne T. F. D.
name: Wouters, Michel W. J. M.
name: KleinJan, Eline
name: Mulder, Maurice
name: Essers, Marion
name: Hurkmans, Coen W.
name: Bijker, Nina
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Plant Biology

description: Additional file 1. Example of a mapping table to map ROI names to variable names. CT-scan, computed tomography scan; Gy, Gray; SIB, simultaneous integrated boost In order to let departments use their own ROIs names they had to fill out a mapping table. a. ROIs descriptions mentioned in the table are examples and may differ per institution b. Based on the average dose calculated in the ROIs and if within certain ranges, mapped to prescribed dose c. Based on total dose in the boost PTV (SIB: elective + boost dose; sequential: boost dose).
A Bronze Age Cordoned Urn, jet bead and other artefacts from Greystoke Moor, Cumbria, with notes on fusiform beads, necklaces, and Cumbrian ornaments in jet.
Creators: name: Richardson, Colin
name: Hallam, Ann M
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 95, 35-54
description: There is a separately authored `Report on the cremated skeletal material' by Joy Langston (48).
Der Tanz der kleinen Spirochäten : theatrale Hygieneaufklärung und die Bekämpfung der Geschlechtskrankheiten in der frühen Sowjetunion
Creators: name: Kosenko, O.
name: Polianski, I. J.
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Medizingeschichte
subject: Gesundheitliche Aufklärung
subject: Sexuell übertragbare Infektionen
subject: History of medicine
subject: Theatre
subject: Sexually transmitted infections
subject: DDC 610 / Medicine & health
subject: DDC 900 / History
subject: Sexually transmitted diseases; Prevention and control
subject: USSR
subject: Syphilis
subject: Health education
subject: Health promotion
subject: Drama
subject: Sowjetunion
subject: Theater
subject: Geschlechtskrankheit
subject: Gesundheitserziehung
subject: Syphilis

description: Der vorliegende Beitrag untersucht antivenerische Theateraufführungen als Mittel zur Bekämpfung von Geschlechtskrankheiten in der frühen Sowjetunion. Er fragt danach, in welchen Bildern, Figuren und Handlungen das venerologische Wissen auf der Theaterbühne zur Darstellung kam, welche Genretraditionen und kommunikative Mittel benutzt wurden sowie wie das Publikum und die Theaterkritik das Bühnengeschehen aufnahm. Zu diesem Zweck werden Archivquellen, ausgewählte Texte antivenerischer Gerichtsspiele und Dramen sowie Berichte und Rezensionen in der Tagespresse ausgewertet.
Constructing pseudowords with constraints on morphological features : application for Polish pseudonouns and pseudoverbs
Creators: name: Dołżycka, Joanna Daria
name: Nikadon, Jon
name: Formanowicz, Magdalena
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Pseudowords
subject: Linguistic processing
subject: Wuggy
subject: DDC 150 / Psychology
subject: Psycholinguistics
subject: Linguistic analysis (Linguistics)
subject: Grammar
subject: Psycholinguistik
subject: Sprachverarbeitung

description: Pseudowords allow researchers to investigate multiple grammatical or syntactic aspects of language processing. In order to serve that purpose, pseudoword stimuli need to preserve certain properties of real language. We provide a Python-based pipeline for the generation of pseudoword stimuli that sound/read naturally in a given language. The pseudowords are designed to resemble real words and clearly indicate their grammatical class for languages that use specific suffixes from parts of speech. We also provide two sets of pseudonouns and pseudoverbs in Polish that are outcomes of the applied pipeline. The sets are equipped with psycholinguistically relevant properties of words, such as orthographic Levenshtein distance 20. We also performed two studies (overall N = 640) to test the validity of the algorithmically constructed stimuli in a human sample. Thus, we present stimuli that were deprived of direct meaning yet are clearly classifiable as grammatical categories while being orthographically and phonologically plausible.
Characterization of metal oxide gas sensors via optical techniques
Creators: name: Glöckler, Johannes
name: Jäschke, Carsten
name: Tütüncü, Erhan
name: Kokoric, Vjekoslav
name: Kocaöz, Yusuf
name: Mizaikoff, Boris
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Metal oxide sensor
subject: MOX
subject: Substrate-integrated hollow waveguide
subject: iHWG
subject: Fluorescence sensor
subject: Gas sensors
subject: Infrared sensors
subject: DDC 540 / Chemistry & allied sciences
subject: DDC 570 / Life sciences
subject: Substrate integrated waveguides
subject: Methane
subject: Carbon dioxide
subject: Oxygen
subject: Methan
subject: Kohlendioxid
subject: Sauerstoff

description: Metal oxide (MOX) sensors are increasingly gaining attention in analytical applications. Their fundamental operation principle is based on conversion reactions of selected molecular species at their semiconducting surface. However, the exact turnover of analyte gas in relation to the concentration has not been investigated in detail to date. In the present study, two optical sensing techniques—luminescence quenching for molecular oxygen and infrared spectroscopy for carbon dioxide and methane—have been coupled for characterizing the behavior of an example semiconducting MOX methane gas sensor integrated into a recently developed low-volume gas cell. Thereby, oxygen consumption during MOX operation as well as the generation of carbon dioxide from the methane conversion reaction could be quantitatively monitored. The latter was analyzed via a direct mid-infrared gas sensor system based on substrate-integrated hollow waveguide (iHWG) technology combined with a portable Fourier transform infrared spectrometer, which has been able to not only detect the amount of generated carbon dioxide but also the consumption of methane during MOX operation. Hence, a method based entirely on direct optical detection schemes was developed for characterizing the actual signal generating processes—here for the detection of methane—via MOX sensing devices via near real-time online analysis.
Arab Nationalism’s Legal Identity and the Progress of the Gulf
Creators: name: Al-Thani, Moza Fahad
Publisher: name: Manara - Qatar Research Repository
Year: 2024
Subjects: classificationCode: 48
subject: Law and legal studies

description: No movement has swept the Arab world in modern history as much as Arab nationalism. With the ideology reaching its heyday under the rule of Gamal Abdel Nasser (1954-1970), Arabs felt that they were reborn, as they were empowered with the feeling of dignity after centuries of being subjugated to colonialism. The impact it had on the formation of the Gulf countries should not go unnoticed. Since the rise of its early features in the late 19th century, Arab nationalism had a legal identity that was reflected in its advocacy for multiple legal principles such as the end of colonialism, achieving self-determination and sovereignty. The people in the Gulf espoused Arab nationalism and its legal values. Bringing the two aspects together, Arab nationalism and law, this LLM thesis analyzes the impact of the movement on the legal development of the Gulf countries. Using a comparative approach, it demonstrates that Arab nationalism had a bigger impact on the legal progress of Bahrain and Kuwait because of the distinct economic and social structures of these countries that allowed them to modernize at an earlier stage relative to their Gulf neighbors. The concomitants that came with modernization, such as quality education and the rise of civil society created greater political opposition. This thesis argues that these factors eventually made the Arab nationalist organizations during Nasser’s tenure in Bahrain and Kuwait more robust, and in turn, the governments’ repressions to these organizations less severe. This feature of Arab nationalism has an anecdotal significance that suggests a theoretical importance regarding the deep relationship between the fields of legal history and socio-legal studies. The historical reconstruction of Arab nationalism’s role in the legal progress of the Gulf assimilates legal history into the socio-legal canon, ultimately creating a rapprochement between the two fields.
Differential forms on hyperelliptic curves with semistable reduction
Creators: name: Kunzweiler, Sabrina
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Hyperelliptic curves
subject: Semistable reduction
subject: Relative dualising sheaf
subject: Primary: 11G20
subject: 14H25
subject: Secondary: 11G40
subject: DDC 510 / Mathematics
subject: Integrals, Hyperelliptic
subject: Differential forms
subject: Differentialform

description: Let C be a hyperelliptic curve over a local field K with odd residue characteristic, defined by some affine Weierstraß equation y2=f(x). We assume that C has semistable reduction and denote by X→SpecOK its minimal regular model with relative dualising sheaf ωX/OK. We show how to directly read off a basis for H0(X,ωX/OK) from the cluster picture of the roots of f. Furthermore we give a formula for the valuation of λ such that λ⋅dx2y∧…∧xg−1dx2y is a generator for detH0(X,ωX/OK).
Beer stein blast to the head a rare case of combined blunt and sharp force trauma
Creators: name: Kunz, S. N.
name: Gorges, N.
name: Fischer, F.
name: Adamec, J.
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Beer stein
subject: Head injury
subject: Assault
subject: Blunt force
subject: Sharp force
subject: DDC 610 / Medicine & health

description: Abstract Cases of combined blunt and sharp force trauma to the head caused by one striking tool are rare. When beer steins are used as an assault weapon, they can cause blunt traumas upon initial contact phase. If the impact force exceeds the mechanical stability of the beer stein, it breaks into several sharp-edged pieces, which then can cause sharp force trauma injuries due to the interaction between the head and the stein fragments. We present a case of a 43-year old man, who suffered from blunt and sharp force head traumas due to one single blow with a 1-l beer stein. A forensic-biomechanical analysis of the event, together with witness testimony evaluation and experimental comparison helped to reconstruct the most probable chain of events. Based on these findings as well as on the medical diagnoses and treatment, the assault was assessed as a nonacute life-threatening, but potentially fatal offence. The case was indicted as grievous bodily harm.