cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Factors influencing magnetic resonance imaging finding of endopelvic fascial edema after ultrasound-guided high-intensity focused ultrasound ablation of uterine fibroids
Creators: name: Liu, Yuhang
name: Liu, Yang
name: Lv, Fajin
name: Zhong, Yuqing
name: Xiao, Zhibo
name: Lv, Furong
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Space Science
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Marine Biology
Science Policy

description: Investigate the relationships between endopelvic fascial edema and its influencing factors after ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation of uterine fibroids. This retrospective study included 688 women with uterine fibroids treated by USgHIFU; based on post-treatment MRI, the patients were divided into two groups: endopelvic fascial edema group and nonedema group. The specific location of fascial edema of each patient was also recorded. Fascial edema and fibroid features and treatment parameters were set as the dependent and independent variables, respectively, and the correlations were studied using univariate and multivariate analyses. The relationship between the pain-related adverse events and location of fascial edema was analyzed by χ2 and fisher's exact tests. Edema and nonedema groups had 556 and 112 patients, respectively. Among the edema patients, posterior fascial edema incidence was the highest. Multifactorial analysis showed that the energy efficiency factor (EEF), fibroid location, and enhancement type were positively associated with endopelvic fascial edema (p < 0.05), while the distance from dorsal surface of the fibroid to sacrum was negatively correlated (p < 0.001). Patients with anterior, posterior and perirectal, and right lateral fascial edemas were associated with lower abdominal pain, sacrococcygeal pain, and leg numbness/pain, respectively. Post-USgHIFU ablation, patients were prone to developing endopelvic fascial edema, and some of them experienced pain-related adverse events. The fibroid location, its types of contrast enhancement, the distance from the dorsal surface of the fibroid to the sacrum, and EEF were the influencing factors resulting in the endopelvic fascial edema after USgHIFU ablation.
Additional file 1 of Fluorescent carbon dots with excellent moisture retention capability for moisturizing lipstick
Creators: name: Dong, Chen
name: Xu, Mingsheng
name: Wang, Shuna
name: Ma, Menghui
name: Akakuru, Ozioma U.
name: Ding, Haizhen
name: Wu, Aiguo
name: Zha, Zhengbao
name: Wang, Xuemei
name: Bi, Hong
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Marine Biology
subject: Computational Biology

description: Additional file 1: Fig. S1. High-resolution TEM image of Car-CDs. Fig. S2. Raman spectra of Car-CDs (λex = 532 nm). Fig. S3. Absolute fluorescence quantum yield of Car-CDs in methanol. Fig. S4. PL emission spectra of the Car-CDs and carmine cochineal under different conditions. Fig. S5. PL emission spectra with different excitation wavelengths of Car-CDs in methanol. Fig. S6. PL lifetime of Car-CDs. Fig. S7. The relationship between hygroscopicity and time at RH = 43% a and RH = 81% b for different samples. The relationship between moisture retention and time at RH = 43% c and RH = 81% d for different samples.
Quantum Surface and Intertwiner Dynamics in Loop Quantum Gravity
Creators: name: Feller, Alexandre
name: Livine, Etera R.
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We introduce simple generic models of surface dynamics in loop quantum gravity (LQG). A quantum surface is defined as a set of elementary patches of area glued together. We provide it with an extra structure of locality (nearest neighbors), thought of as induced by the whole spin network state defining the 3d bulk geometry around the quantum surface. Here, we focus on classical surface dynamics, using a spinorial description of surface degrees of freedom. We introduce two classes of dynamics, to be thought as templates for future investigation of LQG dynamics with in mind the dynamics of quantum black holes. The first defines global dynamics of the closure defect of the surface, with two basic toy-models, either a dissipative dynamics relaxing towards the closure constraint or a Hamiltonian dynamics precessing the closure defect. The second class of dynamics describes the isolated regime, when both area and closure defect are conserved throughout the evolution. The surface dynamics is implemented through U(N) transformations and generalizes to a Bose-Hubbard Hamiltonian with a local quadratic potential interaction. We briefly discuss the implications of modeling the quantum black hole dynamics by a surface Bose-Hubbard model.
description: 20 pages
A Riemann Zeta magnitude growth function based on the Riemann Siegel Theta function closely mirrors the $|t^{-0.1548}\zeta(0.5+it)|$ behaviour for t < 10000.
Creators: name: Martin, John
Publisher: name: figshare
Year: 2018
Subjects: subject: 10199 Pure Mathematics not elsewhere classified
subject: FOS: Mathematics

description: Using the continuous composite function θ(t) + e iθ(t) ζ(0.5 + it) and imposing the condition that
max(|ζ norm (0.5 + it)|) = π(1 + γ/2), a growth factor expression for ζ(0.5 + it) can be derived.
The growth factor closely mirrors, for low t < 10000 the current known Lindelof Hypothesis bound
t −0.1548 |ζ(0.5 + it)|. The deviation for large t compared to max(|ζ norm (0.5 + it)|) = π(1 + γ/2) for
both growth estimates suggests extra functional dependence is required to improve both estimates or
max(|ζ norm (0.5 + it)|) = π(1 + γ/2) + f (t).
Galactic Chemical Evolution: the Impact of the 13C-pocket Structure on the s-process Distribution
Creators: name: Bisterzo, S.
name: Travaglio, C.
name: Wiescher, M.
name: Käppeler, F.
name: Gallino, R.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The solar s-process abundances have been analyzed in the framework of a Galactic Chemical Evolution (GCE) model. The aim of this work is to implement the study by Bisterzo et al. (2014), who investigated the effect of one of the major uncertainties of asymptotic giant branch (AGB) yields, the internal structure of the 13C pocket. We present GCE predictions of s-process elements computed with additional tests in the light of the suggestions provided in recent publications. The analysis is extended to different metallicities, by comparing GCE results and updated spectroscopic observations of unevolved field stars. We verify that the GCE predictions obtained with different tests may represent, on average, the evolution of selected neutron-capture elements in the Galaxy. The impact of an additional weak s-process contribution from fast-rotating massive stars is also explored.
description: 36 pages, 7 figures, 2 tables, accepted
Research in Retrospect: The Animal Bones from Daima, Northeast Nigeria
Creators: name: Fagan, Brian M.
Publisher: name: Brill Online
Year: 2022
Subjects: Archaeology of Asia, Africa and the Americas

description: This brief report describes the animal bones from the first millennium BC discovered during Graham Connah’s excavations at Daima Mound in northeastern Nigeria in 1965-66. The faunal research was completed by the author in 1973, but, owing to various circumstances, it has not been possible to publish the report until now. Eighty percent of the 657 positively identified bones come from domestic cattle, probably a small-statured breed. They were mostly slaughtered while young adults, which suggests they were surplus males. Small stock, probably goats, and also hunting were less important. The inhabitants consumed shallow water fish, mainly Clariidae (catfish), easily trapped in shallow pools. The small Daima collection confirms faunal data from other Lake Chad sites, which show that cattle herding was an important activity during the first millennium BC.
Draft - ISO 15530-X : Sensitivity analysis
Creators: name: Płowucha, Wojciech
Publisher: name: Zenodo
Year: 2019
Subjects: Normative, GPS, CMM, encertainty evaluation, Sensitivity analysis

description: pre-draft of a proposal for new part of ISO 15530 series dealing with "Sensitivity analysis".
description: EMPIR Grant Agreement 17NRM03 EUCoM - This project has received funding from the EMPIR programme co-financed by the Participating States and from the European Union's Horizon 2020 research and innovation programme.
SINXRON TARJIMADA GRAMMATIK TRANSFORMATSIYALARNING AHAMIYATI
Creators: name: Raufov, Miraziz
Publisher: name: Zenodo
Year: 2025

description: Mazkur maqolada sinxron tarjima jarayonida grammatik transformatsiyalarning tutgan o‘rni va ularning tarjima sifati va ma’no aniqligiga ta'siri tahlil qilinadi. Tarjima jarayonida sintaktik, morfologik va uslubiy o‘zgarishlarning zaruriyati, ularning turlari va qo‘llanish usullari haqida fikr yuritiladi. O‘zbekiston va xorijiy olimlar tadqiqotlari asosida grammatik transformatsiyalarning nazariy va amaliy jihatlari yoritiladi.
Magnetic resonance imaging parameter-based machine learning for prognosis prediction of high-intensity focused ultrasound ablation of uterine fibroids
Creators: name: Zhang, Jinwei
name: Yang, Chao
name: Gong, Chunmei
name: Zhou, Ye
name: Li, Chenghai
name: Li, Faqi
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Plant Biology
subject: FOS: Biological sciences

description: Objectives: To develop and apply magnetic resonance imaging (MRI) parameter-based machine learning (ML) models to predict non-perfused volume (NPV) reduction and residual regrowth of uterine fibroids after high-intensity focused ultrasound (HIFU) ablation. Methods: MRI data of 573 uterine fibroids in 410 women who underwent HIFU ablation from the Chongqing Haifu Hospital (training set, N = 405) and the First Affiliated Hospital of Chongqing Medical University (testing set, N = 168) were retrospectively analyzed. Fourteen MRI parameters were screened for important predictors using the Boruta algorithm. Multiple ML models were constructed to predict NPV reduction and residual fibroid regrowth in a median of 203.0 (interquartile range: 122.5–367.5) days. Furthermore, optimal models were used to plot prognostic prediction curves. Results: Fourteen features, including postoperative NPV, indicated predictive ability for NPV reduction. Based on the 10-fold cross-validation, the best average performance of multilayer perceptron achieved with R2 was 0.907. In the testing set, the best model was linear regression (R2 =0.851). Ten features, including the maximum thickness of residual fibroids, revealed predictive power for residual fibroid regrowth. Random forest model achieved the best performance with an average area under the curve (AUC) of 0.904 (95% confidence interval (CI), 0.869–0.939), which was maintained in the testing set with an AUC of 0.891 (95% CI, 0.850–0.929). Conclusions: ML models based on MRI parameters can be used for prognostic prediction of uterine fibroids after HIFU ablation. They can potentially serve as a new method for learning more about ablated fibroids.
MOESM2 of Putative biomarkers for predicting tumor sample purity based on gene expression data
Creators: name: Li, Yuanyuan
name: Umbach, David
name: Bingham, Adrienna
name: Li, Qi-Jing
name: Zhuang, Yuan
name: Li, Leping
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: Additional file 2: Table S1. Number of samples with both ABSOLUTE tumor purity data and RNA-seq gene expression data for each of the 33 tumor types.
Dependence of homogeneous crystal nucleation in water droplets on their radii and its implication for modeling the formation of ice particles in cirrus clouds
Creators: name: Djikaev, Yuri S.
name: Ruckenstein, Eli
Publisher: name: arXiv
Year: 2017
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Atmospheric and Oceanic Physics (physics.ao-ph)
subject: FOS: Physical sciences

description: We propose an approximation for the total ice nucleation rate J=J(T,R) in supercooled water droplets as a function of both droplet radius R and temperature T, taking account of both volume-based and surface-stimulated nucleation modes. Its crucial idea is that, even in the surface-stimulated mode crystal nuclei initially emerge (as sub-critical clusters) homogeneously in the sub-surface layer, not "pseudo-heterogeneously" at the surface. This mode is negligible in large droplets, but becomes increasingly important with decreasing droplet size and is dominant in small droplets. The crossover droplet radius for the transition of homogeneous ice nucleation from the volume-based mode to the surface-stimulated mode nonmonotonically depends on T from 233 K to 239.5 K, ranging there from about 2 microns to about 100 microns. Using experimental data on ice nucleation rates in small droplets, we determine that the ice-air interfacial tension of basal facets of ice crystals monotonically increases from about 89 dyn/cm at T=234.8 K to about 91 dyn/cm at T=236.2 K.
description: arXiv admin note: text overlap with arXiv:1702.02500
MOESM8 of DeepMF: deciphering the latent patterns in omics profiles with a deep learning method
Creators: name: Chen, Lingxi
name: Xu, Jiao
name: Li, Shuai
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Mental Health
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 8 DMF imputation and factorization results on 70% sparse cancer data sets. A-D The heatmap presentation and Silhouette width of four cancer data sets with 70% random dropout. The gray tiles in heatmap indicate missing entries. From left to right: matrix with 70% random dropout, after DMF. The bottom: hierarchical clustering plots for sample latent matrice generated by DMF. A Medulloblastoma data set; B Leukemia data set; C TCGA BRCA data set; D SRBCT data set.
Individual project on theme "Phoca largha Pallas, 1881" (MOOC: CompTech in biology)
Creators: name: Koltysheva, Polina
Publisher: name: Zenodo
Year: 2022

description: Данный кейс является результатом реализации индивидуального проекта Полины Колтышевой по теме "Phoca largha Pallas, 1881" в рамках онлайн курса "Компьютерные технологии в биологии" (автор – А.В. Ваганов) (https://stepik.org/course/60859/promo)
title: ADCO, Cart. 186 (11 H 71), f. 0206v
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: Petot, Frédéric
name: CBMA/CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, t. II (XVe siècle), tome II, Archives départementales de la Côte-d'Or, C
art. 186 (11 H 71). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, t. II (XVe siècle), tome II, Archives départementales de la
 Côte-d'Or, Cart. 186 (11 H 71), f. 0206v, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-
project.eu/
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
Radiotherapy and hyperthermia for breast cancer patients at high risk of recurrence
Creators: name: De-Colle, Chiara
name: Beller, Anna
name: Gani, Cihan
name: Weidner, Nicola
name: Heinrich, Vanessa
name: Lamprecht, Ulf
name: Gaupp, Stephan
name: Voigt, Otilia
name: Dohm, Oliver
name: Zips, Daniel
name: Müller, Arndt-Christian
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: To evaluate the long-term efficacy of combined radiotherapy (RT) and hyperthermia (HT) in a large mono-institutional cohort of breast cancer (BC) patients affected by recurrent, newly diagnosed non-resectable or high risk resected tumor. Records of BC patients treated with RT + HT between 1995 and 2018 were retrospectively analyzed. RT doses of 50–70 Gy concurrent to a twice per week superficial HT were applied. For HT, a temperature between 41 and 42 °C was applied for approximately 1 h. Primary endpoint was local control (LC), secondary endpoints comprised toxicity, overall survival (OS), and progression-free survival (PFS). A total of 191 patients and 196 RT + HT treatments were analyzed. In 154 cases (78.6%) RT + HT was performed for patients with recurrent BC. Among these, 93 (47.4% of the entire cohort) had received RT prior to RT + HT. Median follow up was 12.7 years. LC at 2, 5, and 10 years was 76.4, 72.8, and 69.5%, respectively. OS at 2, 5, and 10 years was 73.5, 52.3, and 35.5%, respectively. PFS at 2, 5, and 10 years was 55.6, 41, and 33.6%, respectively. Predictive factors for LC were tumor stage, distant metastases, estrogen/progesterone receptor expression, resection status and number of HT fractions. At multivariate analysis tumor stage and receptor expression were significant. No acute or late toxicities higher than grade 3 were observed. Combined RT + HT offers long-term high LC rates with acceptable toxicity for patients with recurrent, newly diagnosed non-resectable or resected BC at high risk of relapse.
Robust odd-parity superconductivity in the doped topological insulator Nb$_x$Bi$_2$Se$_3$
Creators: name: Smylie, M. P.
name: Willa, K.
name: Claus, H.
name: Snezhko, A.
name: Martin, I.
name: Kwok, W. -K.
name: Qiu, Y.
name: Hor, Y. S.
name: Bokari, E.
name: Niraula, P.
name: Kayani, A.
name: Mishra, V.
name: Welp, U.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We present resistivity and magnetization measurements on proton-irradiated crystals demonstrating that the superconducting state in the doped topological superconductor Nb$_x$Bi$_2$Se$_3$ (x = 0.25) is surprisingly robust against disorder-induced electron scattering. The superconducting transition temperature $T_c$ decreases without indication of saturation with increasing defect concentration, and the corresponding scattering rates far surpass expectations based on conventional theory. The low-temperature variation of the London penetration depth $Δλ(T)$ follows a power law ($Δλ(T)\sim T^2$) indicating the presence of symmetry-protected point nodes. Our results are consistent with the proposed robust nematic $E_u$ pairing state in this material.
description: 6 pages, 5 figures
Manipulation of entanglement sudden death in an all-optical setup
Creators: name: Singh, Ashutosh
name: Pradyumna, Siva
name: Rau, A. R. P.
name: Sinha, Urbasi
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The unavoidable and irreversible interaction between an entangled quantum system and its environment causes decoherence of the individual qubits as well as degradation of the entanglement between them. Entanglement sudden death (ESD) is the phenomenon wherein disentanglement happens in finite time even when individual qubits decohere only asymptotically in time due to noise. Prolonging the entanglement is essential for the practical realization of entanglement-based quantum information and computation protocols. For this purpose, the local NOT operation in the computational basis on one or both qubits has been proposed. Here, we formulate an all-optical experimental set-up involving such NOT operations that can hasten, delay, or completely avert ESD, all depending on when it is applied during the process of decoherence. Analytical expressions for these are derived in terms of parameters of the initial state's density matrix, whether for pure or mixed entangled states. After a discussion of the schematics of the experiment, the problem is theoretically analyzed, and simulation results of such manipulations of ESD are presented.
title: ADCO, Boursier de Cîteaux : comptes (1489-1493) (11 H 1166), f. 00113
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédéric
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: comptes
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Boursier de Cîteaux : comptes (1489-1493), Archives départementales de la Côte-d'Or, (11 H 1166). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Boursier de Cîteaux : comptes (1489-1493), Archives départementales de la Côte-d'Or, (11 H 1166), f. 00113, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Quantum dynamics of bound states under spacetime fluctuations
Creators: name: Oniga, Teodora
name: Wang, Charles H. -T.
Publisher: name: arXiv
Year: 2016
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: With recent developments in high-precision quantum measurements, the question of whether observations of decoherence from spacetime fluctuations are accessible experimentally arises. Here we investigate the dynamics of bound states interacting with an environment of gravitons under the Markov approximation. The corresponding Lindblad master equation is presented that enables gravitational decoherence and dissipation due to zero-point spacetime fluctuations to be analyzed. Specifically, we consider a one-dimensional cavity of massless scalar particles that models a light beam with negligible spin polarizations being reflected between two free masses. Numerical simulations have been performed to illustrate the wave-modal dependent decoherence and dissipation of such a configuration. We further demonstrate the existence of nontrivial collective effects akin to superradiance, providing amplifications of gravitational decoherence for a large number of identical bosonic particles.
description: 9 pages; Submitted for the IARD 2016 Proceedings
Characterization and initial demonstration of in vivo efficacy of a novel heat-activated metalloenediyne anti-cancer agent
Creators: name: Garrett, Joy
name: Metzger, Erin
name: Dewhirst, Mark W.
name: Pollok, Karen E.
name: Turchi, John J.
name: Le Poole, Isabelle C.
name: Couch, Kira
name: Lew, Logan
name: Sinn, Anthony
name: Zaleski, Jeffrey M.
name: Dynlacht, Joseph R.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Enediynes are anti-cancer agents that are highly cytotoxic due to their propensity for low thermal activation of radical generation. The diradical intermediate produced from Bergman cyclization of the enediyne moiety may induce DNA damage and cell lethality. The cytotoxicity of enediynes and difficulties in controlling their thermal cyclization has limited their clinical use. We recently showed that enediyne toxicity at 37 °C can be mitigated by metallation, but cytotoxic effects of ‘metalloenediynes’ on cultured tumor cells are potentiated by hyperthermia. Reduction of cytotoxicity at normothermia suggests metalloenediynes will have a large therapeutic margin, with cell death occurring primarily in the heated tumor. Based on our previous in vitro findings, FeSO4-PyED, an Fe co-factor complex of (Z)-N,N′-bis[1-pyridin-2-yl-meth-(E)-ylidene]oct-4-ene-2,6-diyne-1,8-diamine, was prioritized for further in vitro and in vivo testing in normal human melanocytes and melanoma cells. Clonogenic survival, apopotosis and DNA binding assays were used to determine mechanisms of enhancement of FeSO4-PyED cytotoxicity by hyperthermia. A murine human melanoma xenograft model was used to assess in vivo efficacy of FeSO4-PyED at 37 or 42.5 °C. FeSO4-PyED is a DNA-binding compound. Enhancement of FeSO4-PyED cytotoxicity by hyperthermia in melanoma cells was due to Bergman cyclization, diradical formation, and increased apoptosis. Thermal enhancement, however, was not observed in melanocytes. FeSO4-PyED inhibited tumor growth when melanomas were heated during drug treatment, without inducing normal tissue damage. By leveraging the unique thermal activation properties of metalloenediynes, we propose that localized moderate hyperthermia can be used to confine the cytotoxicity of these compounds to tumors, while sparing normal tissue.
Population of collective modes in light scattering by many atoms
Creators: name: Guerin, William
name: Kaiser, Robin
Publisher: name: arXiv
Year: 2017
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The interaction of light with an atomic sample containing a large number of particles gives rise to many collective (or cooperative) effects, such as multiple scattering, superradiance and subradiance, even if the atomic density is low and the incident optical intensity weak (linear optics regime). Tracing over the degrees of freedom of the light field, the system can be well described by an effective atomic Hamiltonian, which contains the light-mediated dipole-dipole interaction between atoms. This long-range interaction is at the origin of the various collective effects, or of collective excitation modes of the system. Even though an analysis of the eigenvalues and eigenfunctions of these collective modes does allow distinguishing superradiant modes, for instance, from other collective modes, this is not sufficient to understand the dynamics of a driven system, as not all collective modes are significantly populated. Here, we study how the excitation parameters, i.e. the driving field, determines the population of the collective modes. We investigate in particular the role of the laser detuning from the atomic transition, and demonstrate a simple relation between the detuning and the steady-state population of the modes. This relation allows understanding several properties of cooperative scattering, such as why superradiance and subradiance become independent of the detuning at large enough detuning without vanishing, and why superradiance, but not subradiance, is suppressed near resonance.
Steady state and time resolved optical characterization studies of Zn2SnO4 nanowires for solar cell applications
Creators: name: Baichhabi Yakami
Publisher: name: figshare
Year: 2018
Subjects: subject: 30303 Optical Properties of Materials
subject: FOS: Chemical sciences

description: Nanowires are a promising option for sensitized solar cells, sensors, and display technology. Mostof the work thus far has focused on binary oxides for these nanowires, but ternary oxides haveadvantages in additional control of optical and electronic properties. Here, we report on the diffusereflectance, Low Temperature and Room Temperature Photoluminescence (PL), PL excitationspectrum, and Time Resolved PL (TRPL) of Zinc Tin Oxide (ZTO) nanowires grown by ChemicalVapor Deposition. The PL from the ZTO nanowires does not exhibit any band gap or near gapemission, and the diffuse reflectance measurement confirms that these ZTO nanowires have adirect forbidden transition. The broad PL spectrum reveals two Gaussian peaks centered at 1.86 eV(red) and 2.81 eV (blue), representing two distinct defect states or complexes. The PL spectra werefurther studied by the Time Resolved Emission Spectrum and intensity dependent PL and TRPL.The time resolved measurements show complex non-exponential decays at all wavelengths, indicativeof defect to defect transitions, and the red emissive states decay much slower than the blueemissive states. The effects of annealing in air and vacuum are studied to investigate the origin ofthe defect states in the nanowires, showing that the blue states are related to oxygen vacancies. Wepropose an energy band model for the nanowires containing defect states within the band gap andthe associated transitions between these states that are consistent with our measurements.
Additional file 1 of Regulating immune memory and reversing tumor thermotolerance through a step-by-step starving-photothermal therapy
Creators: name: Luo, Lihua
name: Qin, Bing
name: Jiang, Mengshi
name: Xie, Lin
name: Luo, Zhenyu
name: Guo, Xuemeng
name: Zhang, Junlei
name: Li, Xiang
name: Zhu, Chunqi
name: Du, Yongzhong
name: Peng, Ling
name: You, Jian
Publisher: name: figshare
Year: 2021
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1: Figure S1. The hydrated particle size of MS measured by dynamic light scattering (A) and in vitro cytotoxicity of HAuNS-Met@MS at various concentration. Figure S2. The standard curve of Met through HPLC. Figure S3. Proliferation curve of CD8+T cell. Figure S4. (A) IC50 of free 2DG, Met and 2DG plus Met on B16F10 cells. (B) Cell viability of B16F10 after being incubated with free 2DG and Met at different concentration. Figure S5. Mitochondrial membrane potential fluorescence of B16F10 tumor cells. Figure S6. (A) Mitochondrial membrane potential fluorescence of EG7-OVA tumor cells. (B) Flow cytometry plot of mitochondrial membrane potential fluorescence. (C) Quantification based on (B). Figure S7. Representative flow cytometry plots (A) and quantification (B) of apoptosis rates of EG7-OVA cells. Figure S8. Flow cytometry analysis of DC maturation by analyzing CD11c+MHCI+ DCs. Figure S9. H&E staining of skin, lymph nodes, and tumor tissues isolated from B16F10 tumor bearing mice, the red arrows indicate areas of inflammation. Figure S10. Treatment and administration strategy. Figure S11. (A) Flow cytometry plots of DC and OVA-specific DC in lymph nodes of EG7-OVA mice, (B) Quantification of flow cytometry based on (A). Figure S12. Flow cytometry of lymphocytes (A), CD3+T (B) and CD3+CD8+T cells (C) in lymph nodes of EG7-OVA mice. Figure S13. Flow cytometry plots of OVA-specific CD8+T cells in lymph nodes (A), PBMC (B) and spleen (C) of EG7-OVA mice. Figure S14. Flow cytometry of CD3+T cells in tumor of EG7-OVA mice. Figure S15. EG7-OVA tumor model on C57 mice. Figure S16. B16F10 tumor model on C57 mice. Figure S17. H&E assays of tumor cells in the MS (+) NIR plus 2DG group. Figure S18. Flow cytometry plots of CD8+ T cells in LNs, spleen and PBMCs after different treatments. Figure S19. Immunofluorescence images of Treg cells and functional CD8+T cells infiltrated tumor sections after different treatments (A); (B) Quantitation of Treg cells based on flow cytometry; (C) Quantitation of Treg cells based on immunofluorescence images.
title: 02_1160
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
EOSC Services Need Local Support
Creators: name: Assinen, Pauli
Publisher: name: Zenodo
Year: 2020
Subjects: EOSC
data management support
open science

description: For researchers EOSC services are hard to find. Organizational level support services can help to make EOSC services to be better known and to increase the use of them. On the other hand, it is not clear to all organizations how to organize support services, especially if the resources are very limited. This poster presents work done in the Finnish Open Science Open Data Expert Panel Working Group RDM support services for researcher. One aim of the working group is to make a list of things/capabilities research support services should provide to researchers to help them to use e.g. EOSC services to comply with the requirements of the responsible research data management. When we relate EOSC services to this work, we have two questions: Question 1: How to find EOSC services? Answer 1: Use one of the several portals and catalogues introducing EOSC services: eInfraCentral portal, https://einfracentral.eu/basic-page/einfracentral-catalogue EGI services and marketplace, https://www.egi.eu/services/ / https://marketplace.egi.eu/ EOSCHub services portal, https://www.eosc-hub.eu/services EOSC Marketplace, https://marketplace.eosc-portal.eu/services EOSC-portal, https://www.eosc-portal.eu/ EUDAT service catalogue, https://eudat.eu/catalogue GEANT services, https://www.geant.org/Services OpenAIRE portal, http://catalogue.openaire.eu/search and probably others not mentioned here Question 2: Should we instruct researchers to search services from these sources? Answer 2: No. They are too complicated for searching, if you are not familiar with these services. We need support services helping researcher in finding appropriate services for their discipline and data. This was feedback for example in the OpenAIRE National Event Making sense of Open Science Jungle (6). Second answer means that we need local support services to enhance the use of the EOSC services.
MPEC 2024-G149 : 2024 GB3
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 GB3

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Well-posedness and scattering for the Boltzmann equations: Soft potential with cut-off
Creators: name: He, Lingbing
name: Jiang, Jin-Cheng
Publisher: name: arXiv
Year: 2017
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: We prove the global existence of the unique mild solution for the Cauchy problem of the cut-off Boltzmann equation for soft potential model $γ=2-N$ with initial data small in $L^N_{x,v}$ where $N=2,3$ is the dimension. The proof relies on the existing inhomogeneous Strichartz estimates for the kinetic equation by Ovcharov and convolution-like estimates for the gain term of the Boltzmann collision operator by Alonso, Carneiro and Gamba. The global dynamics of the solution is also characterized by showing that the small global solution scatters with respect to the kinetic transport operator in $L^N_{x,v}$. Also the connection between function spaces and cut-off soft potential model $-N
description: 12 pages
MOESM3 of Putative biomarkers for predicting tumor sample purity based on gene expression data
Creators: name: Li, Yuanyuan
name: Umbach, David
name: Bingham, Adrienna
name: Li, Qi-Jing
name: Zhuang, Yuan
name: Li, Leping
Publisher: name: figshare
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Plant Biology

description: Additional file 3: Table S2. Cancer cell proportion in tumor samples from triple negative breast cancer patients.
Aspartate aminotransferase-to-platelet ratio index for predicting late recurrence of hepatocellular carcinoma after radiofrequency ablation
Creators: name: Zhang, Xinyuan
name: Xin, Yujing
name: Yang, Yi
name: Chen, Yi
name: Cao, Xiao-jing
name: Wang, Yanan
name: Fan, Qingsheng
name: Zhou, Xiang
name: Li, Xiao
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Cancer
Science Policy

description: Our study aimed to explore the prognostic value of the aspartate aminotransferase–platelet ratio index (APRI) and to develop a new nomogram for patients with hepatocellular carcinoma (HCC) who experience late recurrence after radiofrequency ablation (RFA). To date, no study has explored the value of APRI for assessing the late recurrence of HCC after RFA. The prognostic value of APRI was evaluated and validated in our multicenter retrospective analysis. A total of 466 HCC patients undergoing RFA were reviewed as a training cohort, and 234 HCC patients were included in the external validation cohort. The nomogram was built based on significant prognostic factors in a multivariate analysis and validated in the external validation cohort. The cutoff APRI score was 0.78, and it appropriately discriminated between low- and high-risk groups for late recurrence in HCC patients. The cumulative recurrence-free survival rates of the low-risk group were significantly higher than those of the high-risk group (p < 0.001), according to the Kaplan–Meier curves. Late recurrence in HCC patients after RFA was associated with APRI, sex and multiple tumors. The nomogram based on potential risk factors (APRI score, sex and multiple tumors) as indicated by multivariate Cox regression analysis showed good discrimination and calibration in the training and external verification groups. The APRI score is a feasible independent prognostic factor for the late recurrence of HCC after RFA. The proposed nomogram could aid clinicians in following disease progression and providing tailored therapy for patients.
A Universal Self-Amplification Channel for Surface Plasma Waves
Creators: name: Deng, Hai-Yao
name: Wakabayashi, Katsunori
name: Lam, Chi-Hang
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We present a theory of surface plasma waves (SPWs) in metals with arbitrary electronic collision rate $1/τ$. We show that there exists a universal intrinsic amplification channel for these waves, as a result of the unique interplay between ballistic electronic motions and the metal surface. The corresponding intrinsic amplification rate $γ_0$ is shown to be independent of $τ$. We also study its dependence on surface scattering properties.
description: 10 pages, 4 figs
Effects of human tissue acoustic properties, abdominal wall shape, and respiratory motion on ultrasound-mediated hyperthermia for targeted drug delivery to pancreatic tumors
Creators: name: Gray, Michael
name: Spiers, Laura
name: Coussios, Constantin
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biophysics
Biochemistry
Space Science
Physical Sciences not elsewhere classified
Medicine
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Cancer
Mental Health

description: PanDox is a Phase-1 trial of chemotherapeutic drug delivery to pancreatic tumors using ultrasound-mediated hyperthermia to release doxorubicin from thermally sensitive liposomes. This report describes trial-related hyperthermia simulations featuring: (i) new ultrasonic properties of human pancreatic tissues, (ii) abdomen deflections imposed by a water balloon, and (iii) respiration-driven organ motion. Pancreas heating simulations were carried out using three patient body models. Pancreas acoustic properties were varied between values found in the literature and those determined from our human tissue study. Acoustic beam distortion was assessed with and without balloon-induced abdomen deformation. Target heating was assessed for static, normal respiratory, and jet-ventilation-controlled pancreas motion. Human pancreatic tumor attenuation is 63% of the literature values, so that pancreas treatments require commensurately higher input intensity to achieve adequate hyperthermia. Abdominal wall deformation decreased the peak field pressure by as much as 3.5 dB and refracted the focal spot by as much as 4.5 mm. These effects were thermally counteracted by sidelobe power deposition, so the net impact on achieving mild hyperthermia was small. Respiratory motion during moving beam hyperthermia produced localized regions overheated by more than 8.0 °C above the 4.0 °C volumetric goal. The use of jet ventilation reduced this excess to 0.7 °C and yielded temperature field uniformity that was nearly identical to having no respiratory motion. Realistic modeling of the ultrasonic propagation environment is critical to achieving adequate mild hyperthermia without the use of real time thermometry for targeted drug delivery in pancreatic cancer patients.
THE ISLAMIC STATE AS A SOURCE OF TERRORIST THREATS
Creators: name: ELAK, Leszek
Publisher: name: Wiedza Obronna
Year: 2022

description: The article presents the Islamic State as a source of terrorist threats. In the eyes of ISIS fighters, the Western world is tantamount to moral corruption, and the lack of any values. By its actions, ISIS aims at pushing the followers of other religions out of the areas defined in the prophecies in the name of cleansing the world from evil. The author analyzes the activity of Islamic extremists in the context of the great wave of migration to Europe from the Middle East region. This phenomenon influenced changes in the international security environment, especially in the European Union countries. The author shows how ISIS, using ideology, pushes Islamic fundamentalists to prepare terrorist attacks. Combating such threats poses major challenges for anti-terrorist services.
description: Wiedza Obronna, Tom 278 Nr 1 (2022)
Determinants of utilization of antenatal care services among adolescent girls and young women in Indonesia
Creators: name: Efendi, Ferry
name: Ching-Min Chen
name: Kurniati, Anna
name: Sarni Maniar Berliana
Publisher: name: figshare
Year: 2018
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Due to the high number of maternal deaths, provision of antenatal care services (ANC) in Indonesia is one of the key aims of the post-Millennium Development Goals agenda. This study aimed to assess the key factors determining use of ANC by adolescent girls and young women in Indonesia. Data from the Indonesia Demographic and Health Survey 2012 were used, with a focus on married adolescent girls (aged 15–19 years, n = 543) and young women (20–24 years, n = 2,916) who were mothers. Bivariate and multiple logistic regression analyses were performed to determine the factors associated with ANC use. The findings indicated that adolescents were less likely to make ANC visits than young women. Richer women were more likely to make four ANC visits in both groups compared to the poorer women. Living in urban areas, higher educational attainment, and lower birth order were also all associated with higher levels of receiving ANC among young women. The results showed that socio-economic factors were related to the use of ANC among adolescent girls and young women. Ongoing health-care interventions should thus put a priority on adolescent mothers coming from poor socio-economic backgrounds.