cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Stabilizing A Vascularized Autologous Matrix with Flexible Magnesium Scaffolds to Reconstruct Dysfunctional Left Ventricular Myocardium in a Large-Animal Feasibility Study
Creators: name: Schilling, Tobias
name: Cebotari, Serghei
name: Kaufeld, Tim
name: Tudorache, Igor
name: Brandes, Gudrun
name: Hartung, Dagmar
name: Wacker, Frank
name: Bauer, Michael
name: Haverich, Axel
name: Hassel, Thomas
Publisher: name: Basel : MDPI
Year: 2023
Subjects: subject: cardiac surgery
subject: magnesium degradation
subject: magnesium scaffold
subject: regenerative myocardial prostheses
subject: transmural left ventricular reconstruction
subject: Dewey Decimal Classification::500 | Naturwissenschaften::570 | Biowissenschaften, Biologie

description: The surgical reconstruction of dysfunctional myocardium is necessary for patients with severe heart failure. Autologous biomaterials, such as vascularized patch materials, have a regenerative potential due to in vivo remodeling. However, additional temporary mechanical stabilization of the biomaterials is required to prevent aneurysms or rupture. Degradable magnesium scaffolds could prevent these life-threatening risks. A left ventricular transmural defect was reconstructed in minipigs with a piece of the autologous stomach. Geometrically adaptable and degradable scaffolds made of magnesium alloy LA63 were affixed on the epicardium to stabilize the stomach tissue. The degradation of the magnesium structures, their biocompatibility, physiological remodeling of the stomach, and the heart’s function were examined six months after the procedure via MRI (Magnetic Resonance Imaging), angiography, µ-CT, and light microscopy. All animals survived the surgery. Stable physiological integration of the stomach patch could be detected. No ruptures of the grafts occurred. The magnesium scaffolds showed good biocompatibility. Regenerative surgical approaches for treating severe heart failure are a promising therapeutic alternative to the currently available, far from optimal options. The temporary mechanical stabilization of viable, vascularized grafts facilitates their applicability in clinical scenarios.
Pseudodifferential operators on filtered manifolds as generalized fixed points
Creators: name: Ewert, Eske
Publisher: name: Zurich : EMS Publ.
Year: 2023
Subjects: subject: filtered manifolds
subject: generalized fixed point algebras
subject: index theory
subject: Pseudodifferential calculus
subject: Rockland condition
subject: tangent groupoid
subject: Dewey Decimal Classification::500 | Naturwissenschaften::510 | Mathematik

description: On filtered manifolds one can define a different notion of order for the differential operators. In this paper, we use generalized fixed point algebras to construct a pseudodifferential extension that reflects this behaviour. In the corresponding calculus, the principal symbol of an operator is a family of operators acting on certain nilpotent Lie groups. The role of ellipticity as a Fredholm condition is replaced by the Rockland condition on these groups. Our approach allows to understand this in terms of the representations of the corresponding algebra of principal symbols. Moreover, we compute the K-theory of this algebra.
Additional file 1: of Management of late-term pregnancy in midwifery- and obstetrician-led care
Creators: name: Kortekaas, Joep
name: Bruinsma, Aafke
name: Keulen, Judit
name: Vandenbussche, Frank
name: Dillen, Jeroen
name: Esteriek Miranda
Publisher: name: Figshare
Year: 2019
Subjects: subject: Cell Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: SF 2 checklist for reporting result of internet Esurveys (CHERRIES) on both questionnaires. (DOCX 24 kb)
Learning with Square Loss: Localization through Offset Rademacher Complexity
Creators: name: Liang, Tengyuan
name: Rakhlin, Alexander
name: Sridharan, Karthik
Publisher: name: arXiv
Year: 2015
Subjects: subject: Machine Learning (stat.ML)
subject: Machine Learning (cs.LG)
subject: Statistics Theory (math.ST)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: We consider regression with square loss and general classes of functions without the boundedness assumption. We introduce a notion of offset Rademacher complexity that provides a transparent way to study localization both in expectation and in high probability. For any (possibly non-convex) class, the excess loss of a two-step estimator is shown to be upper bounded by this offset complexity through a novel geometric inequality. In the convex case, the estimator reduces to an empirical risk minimizer. The method recovers the results of \citep{RakSriTsy15} for the bounded case while also providing guarantees without the boundedness assumption.
description: 21 pages, 1 figure
Development of an inhibiting antibody against equine interleukin 5 to treat insect bite hypersensitivity of horses
Creators: name: Langreder, Nora
name: Schäckermann, Dorina
name: Meier, Doris
name: Becker, Marlies
name: Schubert, Maren
name: Dübel, Stefan
name: Reinard, Thomas
name: Figge-Wegener, Stefanie
name: Roßbach, Kristine
name: Bäumer, Wolfgang
name: Ladel, Simone
name: Hust, Michael
Publisher: name: [London] : Macmillan Publishers Limited, part of Springer Nature
Year: 2021
Subjects: subject: Allergens
subject: Animals
subject: Ceratopogonidae
subject: Horse Diseases
subject: Horses
subject: Dewey Decimal Classification::500 | Naturwissenschaften
subject: Dewey Decimal Classification::600 | Technik

description: Insect bite hypersensitivity (IBH) is the most common allergic skin disease of horses. It is caused by insect bites of the Culicoides spp. which mediate a type I/IVb allergy with strong involvement of eosinophil cells. No specific treatment option is available so far. One concept could be the use of a therapeutic antibody targeting equine interleukin 5, the main activator and regulator of eosinophils. Therefore, antibodies were selected by phage display using the naïve human antibody gene libraries HAL9/10, tested in a cellular in vitro inhibition assay and subjected to an in vitro affinity maturation. In total, 28 antibodies were selected by phage display out of which eleven have been found to be inhibiting in the final format as chimeric immunoglobulin G with equine constant domains. The two most promising candidates were further improved by in vitro affinity maturation up to factor 2.5 regarding their binding activity and up to factor 2.0 regarding their inhibition effect. The final antibody named NOL226-2-D10 showed a strong inhibition of the interleukin 5 binding to its receptor (IC50 = 4 nM). Furthermore, a nanomolar binding activity (EC50 = 8.8 nM), stable behavior and satisfactory producibility were demonstrated. This antibody is an excellent candidate for in vivo studies for the treatment of equine IBH.
National Diabetes Data Group vs Carpenter-Coustan criteria to diagnose gestational diabetes
Creators: name: Stuebe, Alison M.
name: Jonsson Funk, Michele
name: Berggren, Erica K.
name: Boggess, Kim A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: To compare perinatal outcomes among women diagnosed with gestational diabetes by National Diabetes Data Group (NDDG) with women only meeting Carpenter-Coustan criteria.
Testosterone therapy and cancer risks among men in the SEER-Medicare linked database
Creators: name: Curry, M.
name: Butler, E.N.
name: McMenamin, Ú.
name: Bradley, M.C.
name: Zhou, C.K.
name: Cook, M.B.
name: Cardwell, C.
name: Graubard, B.I.
Publisher: name: Springer Nature
Year: 2023

description: Background: We examined associations between two forms of testosterone therapy (TT) and risks of seven cancers among men. Methods: SEER-Medicare combines cancer registry data from the Surveillance, Epidemiology, and End Results programme with Medicare claims. Our population-based case–control study included incident cancer cases diagnosed between 1992–2015: prostate (n = 130,713), lung (n = 105,466), colorectal (n = 56,433), bladder (n = 38,873), non-Hodgkin lymphoma (n = 17,854), melanoma (n = 14,241), and oesophageal (n = 9116). We selected 100,000 controls from a 5% random sample of Medicare beneficiaries and used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI). Results: TT was associated with lower risk of distant-stage prostate cancer (injection/implantation OR = 0.72, 95% CI: 0.60–0.86; topical OR = 0.50, 95% CI: 0.24–1.03). We also observed inverse associations for distant-stage colorectal cancer (injection/implantation OR = 0.75, 95% CI: 0.62–0.90; topical OR = 0.11, 95% CI: 0.05–0.24). Risks of distant-stage colorectal and prostate cancers decreased with time after initiating TT by injection/implantation. By contrast, TT was positively associated with distant-stage melanoma (injection/implantation OR = 1.70, 95% CI: 1.37–2.11). TT was not associated with bladder cancer, oesophageal cancer, lung cancer or non-Hodgkin lymphoma. Conclusion: TT was inversely associated with distant-stage prostate and colorectal cancers but was positively associated with distant-stage melanoma. These observations may suggest an aetiologic role for TT or the presence of residual confounding.
Pharmacokinetics of 17-hydroxyprogesterone caproate in multifetal gestation
Creators: name: Malone, Fergal D.
name: Caritis, Steve N.
name: Thorp, John M.
name: Sciscione, Anthony
name: Sharma, Shringi
name: Peaceman, Alan M.
name: Spong, Catherine Y.
name: Mercer, Brian M.
name: Harper, Margaret
name: Carpenter, Marshall
name: Iams, Jay D.
name: Ramin, Susan
name: Rouse, Dwight J.
name: Lo, Julie
name: Varner, Michael W.
name: Sorokin, Yoram
name: Venkataramanan, Raman
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: To define the pharmacokinetic (PK) parameters of 17-hydroxyprogesterone caproate (17-OHPC) in multifetal gestation.
Pb/InAs nanowire Josephson junction with high critical current and magnetic flux focusing
Creators: name: Paajaste, J.
name: Amado, M.
name: Roddaro, S.
name: Bergeret, F. S.
name: Ercolani, D.
name: Sorba, L.
name: Giazotto, F.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We have studied mesoscopic Josephson junctions formed by highly $n$-doped InAs nanowires and superconducting Ti/Pb source and drain leads. The current-voltage properties of the system are investigated by varying temperature and external out-of-plane magnetic field. Superconductivity in the Pb electrodes persists up to $ \sim 7$ K and with magnetic field values up to 0.4 T. Josephson coupling at zero backgate voltage is observed up to 4.5 K and the critical current is measured to be as high as 615 nA. The supercurrent suppression as a function of the magnetic field reveals a diffraction pattern that is explained by a strong magnetic flux focusing provided by the superconducting electrodes forming the junction.
description: 6 pages, 5 color figures
A physics-informed Bayesian framework for characterizing ground motion process in the presence of missing data
Creators: name: Chen, Yu
name: Patelli, Edoardo
name: Edwards, Benjamin
name: Beer, Michael
Publisher: name: New York, NY [u.a.] : Wiley
Year: 2023
Subjects: subject: Bayesian model updating
subject: earthquake ground motion
subject: evolutionary power spectra
subject: missing data
subject: stochastic variational inference
subject: uncertainty quantification
subject: Dewey Decimal Classification::500 | Naturwissenschaften::550 | Geowissenschaften

description: A Bayesian framework to characterize ground motions even in the presence of missing data is developed. This approach features the combination of seismological knowledge (a priori knowledge) with empirical observations (even incomplete) via Bayesian inference. At its core is a Bayesian neural network model that probabilistically learns temporal patterns from ground motion data. Uncertainties are accounted for throughout the framework. Performance of the approach has been quantitatively demonstrated via various missing data scenarios. This framework provides a general solution to dealing with missing data in ground motion records by providing various forms of representation of ground motions in a probabilistic manner, allowing it to be adopted for numerous engineering and seismological applications. Notably, it is compatible with the versatile Monte Carlo simulation scheme, such that stochastic dynamic analyses are still achievable even with missing data. Furthermore, it serves as a complementary approach to current stochastic ground-motion models in data-scarce regions under the growing interests of PBEE (performance-based earthquake engineering), mitigating the data-model dependence dilemma due to the paucity of data, and ultimately, as a fundamental solution to the limited data problem in data scarce regions.
Fatal prostate cancer incidence trends in the United States and England by race, stage, and treatment
Creators: name: Rosenberg, P.S.
name: Cook, M.B.
name: Coupland, V.H.
name: Butler, E.N.
name: Kelly, S.P.
Publisher: name: Springer Nature
Year: 2020

description: Background: Differential uptake of prostate-specific antigen testing in the US and UK has been linked to between-country differences for prostate cancer incidence. We examined stage-specific fatal prostate cancer incidence trends in the US and England, by treatment and race/ethnicity. Methods: Using data from the National Cancer Institute’s Surveillance, Epidemiology, and End Results program and Public Health England’s National Cancer Registration and Analysis Service, we identified prostate cancer patients diagnosed between 1995 and 2005, aged 45–84 years. Fatal prostate cancer was defined as death attributed to the disease within 10 years of diagnosis. We used age–period–cohort models to assess trends in fatal prostate cancer incidence. Results: Fatal prostate cancer incidence declined in the US by −7.5% each year and increased in England by 7.7% annually. These trends were primarily driven by locoregional disease in the US and distant disease in England. Black men in both countries had twofold to threefold higher fatal prostate cancer incidence rates, when compared with their white counterparts; however, receipt of radical prostatectomy lessened this disparity. Conclusions: We report a significant increasing rate of fatal prostate cancer incidence among English men. The black–white racial disparity appears pervasive but is attenuated among those who received radical prostatectomy in the US.
Placental endothelial nitric oxide synthase in multiple and single dose betamethasone exposed pregnancies
Creators: name: O'Sullivan, Mary J.
name: Spong, Catherine Y.
name: Mertz, Heather L.
name: Ramin, Susan M.
name: Carpenter, Marshall
name: Caritis, Steve N.
name: Wapner, Ronald J.
name: Sorokin, Yoram
name: Iams, Jay D.
name: Dudley, Donald J.
name: Rouse, Dwight J.
name: Miodovnik, Menachem
name: Mercer, Brian M.
name: Mele, Lisa
name: Sibai, Baha
name: Thorp, John M.
name: Leveno, Kenneth J.
name: Peaceman, Alan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: To compare endothelial nitric oxide synthase (eNOS ) expression and capillary density (CDS) in placentas exposed to single or multiple courses of betamethasone.
title: Gravimetric and morpho-structural analyses in the superhot geothermal system Los Humeros: an example from central Mexico
Creators: name: Cornejo-Triviño, Natalia
name: Liotta, Domenico
name: Piccardi, Luigi
name: Brogi, Andrea
name: Kruszewski, Michal
name: Perez-Flores, M.A
name: Carrillo, Jonathan
name: Calcagno, Philippe
name: Sass, Ingo
name: Schill, Eva
Publisher: name: SpringerOpen
Year: 2025

description: The influence of deep and regional geological structures is becoming increasingly important in superhot geothermal systems due to their proximity to the transition between brittleness and ductility. In the Los Humeros geothermal field in Mexico, where subsurface fluids reach temperatures of over 350 °C, the surface structures resulting from the collapse of calderas have so far only been interpreted at the local scale. The aim of this work is to place the recent tectonic and volcano-tectonic geomorphologic evolution and structures in the Los Humeros volcanic area in a regional context. NE- and NW-striking dominant structures resulting from a morpho-structural analysis on a regional scale are confirmed by negative and positive anomalies, respectively, after Butterworth filtering of gravity field data with different wavelengths over a local area of about 1000 km². By analyzing the slip and dilation trends of the observed directions, we show the relevance of the regional context for reservoir exploration. The magnitudes of the principal stresses we estimate indicate a trans-tensional fault regime, a combination of strike-slip and normal faulting. The structures derived from the gravity and morpho-structural analyses, which are parallel to the maximum horizontal stress, have the highest potential for tensile and shear failure. Therefore, the corresponding negative gravity anomalies could be related to fracture porosity. Consequently, we hypothesize that these structures near the transition between brittleness and ductility control fluid flow in the Los Humeros geothermal field.
Die "Verinnerlichung der Normen" als naturalistisches Problem
Creators: name: Löw, Reinhard
Publisher: name: Internationale katholische Zeitschrift Communio
Year: 2022

description: Internationale katholische Zeitschrift Communio, Bd. 22 Nr. 4 (1993): Internationale katholische Zeitschrift Communio, Band 22, Heft 4
Laser cooling a membrane-in-the-middle system close to the quantum ground state from room temperature
Creators: name: Saarinen, Sampo A.
name: Kralj, Nenad
name: Langman, Eric C.
name: Tsaturyan, Yeghishe
name: Schliesser, Albert
Publisher: name: Washington, DC : Optica
Year: 2023
Subjects: subject: Ground state
subject: Laser cooling
subject: Mirrors
subject: Resonators
subject: Room temperature
subject: Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik
subject: Dewey Decimal Classification::600 | Technik::620 | Ingenieurwissenschaften und Maschinenbau

description: Many protocols in quantum science and technology require initializing a system in a pure quantum state. In the context of the motional state of massive resonators, this enables studying fundamental physics at the elusive quantum–classical transition, and measuring force and acceleration with enhanced sensitivity. Laser cooling has been a method of choice to prepare mechanical resonators in the quantum ground state, one of the simplest pure states. However, to overcome the heating and decoherence by the thermal bath, this usually has to be combined with cryogenic cooling. Here, we laser-cool an ultracoherent, soft-clamped mechanical resonator close to the quantum ground state directly from room temperature. To this end, we implement the versatile membrane-in-the-middle setup with one fiber mirror and one phononic crystal mirror, which reaches a quantum cooperativity close to unity already at room temperature. We furthermore introduce a powerful combination of coherent and measurement-based quantum control techniques, which allows us to mitigate thermal intermodulation noise. The lowest occupancy we reach is 30 phonons, limited by measurement imprecision. Doing away with the necessity for cryogenic cooling should further facilitate the spread of optomechanical quantum technologies.
Repeated course antenatal steroids, inflammation gene polymorphisms, and neurodevelopmental outcomes at age 2
Creators: name: Mele, Lisa
name: Rouse, Dwight J.
name: Caritis, Steve N.
name: Thorp, John M.
name: Sorokin, Yoram
name: Spong, Catherine Y.
name: Peaceman, Alan
name: Iams, Jay D.
name: Carpenter, Marshall
name: Wapner, Ronald J.
name: Harper, Margaret
name: Mercer, Brian M.
name: Clark, Erin A.S.
name: Leveno, Kenneth J.
name: Ramin, Susan M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Evaluate the interaction between repeated course antenatal corticosteroids and inflammation gene polymorphisms with neurodevelopmental outcomes at age 2.
Overall and abdominal obesity and prostate cancer risk in a West African population: An analysis of the Ghana Prostate Study
Creators: name: Zhou, C.K.
name: Hoover, R.N.
name: Tettey, Y.
name: Kelly, S.P.
name: Truelove, A.
name: Hurwitz, L.M.
name: Mensah, J.E.
name: Adjei, A.A.
name: Hsing, A.W.
name: Cook, M.B.
name: Butler, E.N.
name: Biritwum, R.B.
name: Yeboah, E.D.
name: Okyne, V.
name: Tay, E.
Publisher: name: Wiley-Liss Inc.
Year: 2020

description: Obesity has been associated with an increased risk of advanced prostate cancer. However, most studies have been conducted among North American and European populations. Prostate cancer mortality appears elevated in West Africa, yet risk factors for prostate cancer in this region are unknown. We thus examined the relationship between obesity and prostate cancer using a case-control study conducted in Accra, Ghana in 2004 to 2012. Cases and controls were drawn from a population-based sample of 1037 men screened for prostate cancer, yielding 73 cases and 964 controls. An additional 493 incident cases were recruited from the Korle-Bu Teaching Hospital. Anthropometric measurements were taken at enrollment. We used logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR) and prostate cancer, adjusting for potential confounders. The mean BMI was 25.1 kg/m2 for cases and 24.3 kg/m2 for controls. After adjustment, men with BMI ≥ 30 kg/m2 had an increased risk of prostate cancer relative to men with BMI < 25 kg/m2 (OR 1.86, 95% CI 1.11-3.13). Elevated WC (OR 1.76, 95% CI 1.24-2.51) and WHR (OR 1.46, 95% CI 0.99-2.16) were also associated with prostate cancer. Associations were not modified by smoking status and were evident for low- and high-grade disease. These findings indicate that overall and abdominal obesity are positively associated with prostate cancer among men in Ghana, implicating obesity as a potentially modifiable risk factor for prostate cancer in this region.
What makes economics special: orientational paradigms
Creators: name: Hoyningen-Huene, Paul
name: Kincaid, Harold
Publisher: name: London : Routledge
Year: 2023
Subjects: subject: experimental economics
subject: Orientational paradigms
subject: production and exchange models
subject: systematicity theory
subject: Thomas Kuhn
subject: utility theory
subject: Dewey Decimal Classification::300 | Sozialwissenschaften, Soziologie, Anthropologie::330 | Wirtschaft

description: From the mid-1960s until the late 1980s, the well-known general philosophies of science of the time were applied to economics. The result was disappointing: none seemed to fit. This paper argues that this is due to a special feature of economics: it possesses ‘orientational paradigms’ in high number. Orientational paradigms are similar to Kuhn’s paradigms in that they are shared across scientific communities, but dissimilar to Kuhn’s paradigms in that they are not generally accepted as valid guidelines for further research. As will be shown by several examples, orientational paradigms provide economics with common points of reference that support its epistemic coherence and make scientific discourse more easily possible across school boundaries. With the help of systematicity theory, a newer general philosophy of science, one can further elucidate the role of orientational paradigms with regard to scientific progress.
Massive N=2 Supergravity in Three Dimensions
Creators: name: Alkac, Gokhan
name: Basanisi, Luca
name: Bergshoeff, Eric A.
name: Ozkan, Mehmet
name: Sezgin, Ergin
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: There exists two distinct off-shell ${\mathcal{N}}=2$ supergravities in three dimensions. They are also referred to as ${\mathcal{N}}=(1,1)$ and ${\mathcal{N}}=(2,0)$ supergravities, and they arise from the coupling of the Weyl multiplet to a compensating scalar or vector multiplet, respectively, followed by fixing of conformal symmetries. The ${\mathcal{N}} =(p,q)$ terminology refers to the underlying anti-de Sitter superalgebras $OSp(2,p) \oplus OSp(2,q)$ with $R$-symmetry group $SO(p) \times SO(q)$. We construct off-shell invariants of these theories up to fourth order in derivatives. As an application of these results, we determine the special combinations of the ${\mathcal{N}}=(1,1)$ invariants that admit anti-de Sitter vacuum solution about which there is a ghost-free massive spin-2 multiplet of propagating modes. We also show that the ${\mathcal{N}}=(2,0)$ invariants do not allow such possibility.
description: 32 pages, v3: Typos Corrected, Version appeared in JHEP
17 alpha-hydroxyprogesterone caproate to prevent prematurity in nulliparas with cervical length less than 30 mm
Creators: name: Tita, Alan T.N.
name: Rouse, Dwight J.
name: Tolosa, Jorge E.
name: Thorp, John M.
name: Sorokin, Yoram
name: Esplin, M. Sean
name: Mercer, Brian M.
name: Wapner, Ronald J.
name: Leveno, Kenneth J.
name: Grobman, William A.
name: Saade, George R.
name: Spong, Catherine Y.
name: Thom, Elizabeth A.
name: Iams, Jay D.
name: Caritis, Steve N.
name: Van Dorsten, J. Peter
name: Blackwell, Sean
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: To evaluate whether 17-alpha hydroxyprogesterone caproate (17-OHP) reduces preterm birth (PTB) in nulliparous women with a midtrimester cervical length (CL) less than 30 mm.
Derivation of Dark Matter Parity from Lepton Parity
Creators: name: Ma, Ernest
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: It is shown that in extensions of the standard model of quarks and leptons where additive lepton number $L$ is broken by two units, so that $Z_2$ lepton parity, i.e. $(-1)^L$ which is either even or odd, remains exactly conserved, there is the possibility of stable dark matter without additional symmetry. This applies to many existing simple models of Majorana neutrino mass with dark matter, including some radiative models. Several well-known examples are discussed. This new insight leads to the construction of a radiative Type II seesaw model of neutrino mass with dark matter where the dominant decay of the doubly charged Higgs boson $ξ^{++}$ is into $W^+W^+$ instead of the expected $l_i^+ l_j^+$ lepton pairs for the well-known tree-level model.
description: 11 pages, 6 figures, version to appear in PRL
Involving patients and their families in deciding to use next generation sequencing: Results from a nationally representative survey of U.S. oncologists
Creators: name: de Moor, J.S.
name: Klein, W.M.P.
name: Spees, L.P.
name: Prabhu Das, I.
name: Roberts, M.C.
name: Freedman, A.N.
name: Butler, E.N.
Publisher: name: Elsevier Ireland Ltd
Year: 2021

description: Objective: Next generation sequencing (NGS) may aid in tumor classification and treatment. Barriers to shared decision-making may influence use of NGS. We examined, from oncologists’ perspectives, whether barriers to involving patients/families in decision-making were associated with NGS use. Methods: Using data from the first national survey of medical oncologists’ perspectives on precision medicine (N = 1281), we approached our analyses in two phases. Bivariate analyses initially evaluated associations between barriers to involving patients/families in deciding to use NGS and provider- and organizational-level characteristics. Modified Poisson regressions then examined associations between patient/family barriers and NGS use. Results: Approximately 59 % of oncologists reported at least one barrier to involving patients/families in decision-making regarding NGS use. Those reporting patient/family barriers tended to have fewer genomic resources at their practices, to be in rural or suburban areas, and to have a higher proportion of Medicaid patients. However, these barriers were not associated with NGS use. Conclusions: Oncologists encounter barriers to involving patients/families in NGS testing decisions. Organizational barriers may also potentially play a role in testing decisions. Practice implications: To foster patient-centered care, strategies to support patient involvement in genomic testing decisions are needed, particularly among practices in low-resource settings.
The Host Galaxies of X-ray Quasars Are Not Strong Star Formers
Creators: name: Barger, A. J.
name: Cowie, L. L.
name: Owen, F. N.
name: Chen, C. -C.
name: Hasinger, G.
name: Hsu, L. -Y.
name: Li, Y.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We use ultradeep SCUBA-2 850um observations (~0.37 mJy rms) of the 2 Ms Chandra Deep Field-North (CDF-N) and 4 Ms Chandra Deep Field-South (CDF-S) X-ray fields to examine the amount of dusty star formation taking place in the host galaxies of high-redshift X-ray AGNs. Supplementing with COSMOS, we measure the submillimeter fluxes of the 4-8 keV sources at z>1, finding little flux at the highest X-ray luminosities but significant flux at intermediate luminosities. We determine gray body and MIR luminosities by fitting spectral energy distributions to each X-ray source and to each radio source in an ultradeep Karl G. Jansky Very Large Array (VLA) 1.4 GHz (11.5uJy at 5-sigma) image of the CDF-N. We confirm the FIR-radio and MIR-radio correlations to z=4 using the non-X-ray detected radio sources. Both correlations are also obeyed by the X-ray less luminous AGNs but not by the X-ray quasars. We interpret the low FIR luminosities relative to the MIR for the X-ray quasars as being due to a lack of star formation, while the MIR stays high due to the AGN contribution. We find that the FIR luminosity distributions are highly skewed and the means are dominated by a small number of high-luminosity galaxies. Thus, stacking or averaging analyses will overestimate the level of star formation taking place in the bulk of the X-ray sample. We conclude that most of the host galaxies of X-ray quasars are not strong star formers, perhaps because their star formation is suppressed by AGN feedback.
description: 16 pages, updated to The Astrophysical Journal accepted version
Fetal male gender and the benefits of treatment of mild gestational diabetes mellitus
Creators: name: Peaceman, Alan M.
name: Carpenter, Marshall W.
name: Caritis, Steve N.
name: Sciscione, Anthony
name: Mele, Lisa
name: Casey, Brian
name: Tolosa, Jorge E.
name: Harper, Margaret
name: Rouse, Dwight J.
name: Thorp, John M.
name: Bahado-Singh, Ray O.
name: Varner, Michael W.
name: Wapner, Ronald J.
name: Saade, George
name: Landon, Mark B.
name: Ramin, Susan M.
name: Catalano, Patrick
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: We evaluated whether improvements in pregnancy outcomes after treatment of mild GDM differed in magnitude based on fetal gender.
Integrability and unitarity
Creators: name: Brandhuber, Andreas
name: Penante, Brenda
name: Travaglini, Gabriele
name: Young, Donovan
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We show how generalised unitarity can be used to determine the one-loop dilatation operator in N=4 super Yang-Mills. Our analysis focuses on two sectors, namely the bosonic SO(6) sector and the SU(2|3) sector. The calculation is performed on shell, with no off-shell information introduced at any stage. In this way, we establish a direct connection between scattering amplitudes and the dilatation operator of the N=4 theory.
description: 13 pages. v2: references and comparison of different on-shell approaches added. v3: typos corrected, comments added
Die egalitäre Gesellschaft und ihre Gefahren
Creators: name: Schipperges, Karl-Josef
Publisher: name: Internationale katholische Zeitschrift Communio
Year: 2022

description: Internationale katholische Zeitschrift Communio, Bd. 22 Nr. 3 (1993): Internationale katholische Zeitschrift Communio, Band 22, Heft 3
Erinnerungen aus der Zeit um und mit Romano Guardini
Creators: name: Baier, Walther
Publisher: name: Internationale katholische Zeitschrift Communio
Year: 2022

description: Internationale katholische Zeitschrift Communio, Bd. 22 Nr. 3 (1993): Internationale katholische Zeitschrift Communio, Band 22, Heft 3
Effective Temperature of Non-equilibrium Dense Matter in Holography
Creators: name: Hoshino, Hironori
name: Nakamura, Shin
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We study properties of effective temperature of non-equilibrium steady states by using the anti-de Sitter spacetime/conformal field theory (AdS/CFT) correspondence. We consider non-equilibrium systems with a constant flow of current along an electric field, in which the current is carried by both the doped charges and those pair created by the electric field. We find that the effective temperature agrees with that of the Langevin systems if we take the limit where the pair creation is negligible. The effect of pair creation raises the effective temperature whereas the current by the doped charges contributes to lower the effective temperature in a wide range of the holographic models.
description: 18 pages, 7 figures
Systematic approach for the development of an FE-based process simulation framework for wet compression moulding of continuously reinforced composites
Creators: name: Poppe, Christian
name: Dörr, Dominik
name: Kärger, Luise
Publisher: name: Karlsruhe
Year: 2019
Subjects: Lightweight-Design
Forming simulation
Infiltration
Fluid-Structure-Interaction

description: Wet compression moulding (WCM) provides large-scale production potential for continuously fibre reinforced structural components as a promising alternative to resin transfer moulding (RTM). Lower cycle times are enabled by parallelisation of the key process steps draping, infiltration and curing during moulding, which is called viscous draping. Experimental and theoretical investigations prove strong mutual dependencies between the physical mechanisms, especially between the resin (fluid) and the stacked laminate [1-4]. To enable a time and cost efficient product and process development throughout all design stages, accurate process simulation tools are desirable. Hitherto, a lack of systematic investigation and understanding of these mutual dependencies prevent further development of suitable numerical methods. Existing sequential draping and mould filling simulations models that are suitable for the RTM process cannot be directly applied to the WCM process, due to the above outlined physical couplings [5]. Numerical approaches published within the field of liquid composite moulding (LCM) [6] or vacuum assisted processes [7] already contain fluid-structure-interaction approaches. However, they cannot be applied either, since they cannot account for desired forming behaviour (large deformations, large contact area and boundary condition), which is necessary for WCM process.
Image analysis with deep learning to predict breast cancer grade, ER status, histologic subtype, and intrinsic subtype
Creators: name: Williams, L.A.
name: Perou, C.M.
name: Marron, J.S.
name: Niethammer, M.
name: Troester, M.A.
name: Geradts, J.
name: Butler, E.N.
name: Nyante, S.J.
name: Couture, H.D.
Publisher: name: Nature Publishing Group
Year: 2018

description: RNA-based, multi-gene molecular assays are available and widely used for patients with ER-positive/HER2-negative breast cancers. However, RNA-based genomic tests can be costly and are not available in many countries. Methods for inferring molecular subtype from histologic images may identify patients most likely to benefit from further genomic testing. To identify patients who could benefit from molecular testing based on H&E stained histologic images, we developed an image analysis approach using deep learning. A training set of 571 breast tumors was used to create image-based classifiers for tumor grade, ER status, PAM50 intrinsic subtype, histologic subtype, and risk of recurrence score (ROR-PT). The resulting classifiers were applied to an independent test set (n = 288), and accuracy, sensitivity, and specificity of each was assessed on the test set. Histologic image analysis with deep learning distinguished low-intermediate vs. high tumor grade (82% accuracy), ER status (84% accuracy), Basal-like vs. non-Basal-like (77% accuracy), Ductal vs. Lobular (94% accuracy), and high vs. low-medium ROR-PT score (75% accuracy). Sampling considerations in the training set minimized bias in the test set. Incorrect classification of ER status was significantly more common for Luminal B tumors. These data provide proof of principle that molecular marker status, including a critical clinical biomarker (i.e., ER status), can be predicted with accuracy >75% based on H&E features. Image-based methods could be promising for identifying patients with a greater need for further genomic testing, or in place of classically scored variables typically accomplished using human-based scoring.
Maternal BMI, glucose tolerance, and adverse pregnancy outcomes
Creators: name: Sciscione, Anthony
name: Peaceman, Alan M.
name: Saade, George
name: Spong, Catherine Y.
name: Carpenter, Marshall W.
name: Catalano, Patrick
name: Wapner, Ronald J.
name: Tolosa, Jorge E.
name: Casey, Brian
name: Stuebe, Alison M.
name: Varner, Michael W.
name: Landon, Mark B.
name: Sorokin, Yoram
name: Lai, Yinglei
name: Rouse, Dwight J.
name: Harper, Margaret
name: Ramin, Susan M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: To estimate the association of pregravid body mass index (BMI), independent of 3-hour oral glucose tolerance test (OGTT) results, with pregnancy outcome.
Design of an efficient klystron
Creators: name: ARIES WP4 Members
Publisher: name: Zenodo
Year: 2021

description: Several future high energy accelerator projects implying large demands for RF power in the range of 10 to 100 MW (FCC-ee, ILC, CLIC, CompactLight, etc) will benefit from increasing the efficiency of the power sources. In this deliverable, we report about a design study of a 12 GHz and around 20 MW peak power klystron with improved efficiency by more than 10% with respect to the tubes available commercially, which could be a candi-date for use at the future CompactLight FEL.
description: {"references": ["ARIES Del4.2"]}
"Esset das Lamm schnell ..."
Creators: name: Gerl-Falkovitz, Hanna-Barbara
Publisher: name: Internationale katholische Zeitschrift Communio
Year: 2022

description: Internationale katholische Zeitschrift Communio, Bd. 22 Nr. 3 (1993): Internationale katholische Zeitschrift Communio, Band 22, Heft 3
High-frequency approximation for periodically driven quantum systems from a Floquet-space perspective
Creators: name: Eckardt, André
name: Anisimovas, Egidijus
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We derive a systematic high-frequency expansion for the effective Hamiltonian and the micromotion operator of periodically driven quantum systems. Our approach is based on the block diagonalization of the quasienergy operator in the extended Floquet Hilbert space by means of degenerate perturbation theory. The final results are equivalent to those obtained within a different approach [Phys.\ Rev.\ A {\bf 68}, 013820 (2003), Phys.\ Rev.\ X {\bf 4}, 031027 (2014)] and can also be related to the Floquet-Magnus expansion [J.\ Phys.\ A {\bf 34}, 3379 (2000)]. We discuss that the dependence on the driving phase, which plagues the latter, can lead to artifactual symmetry breaking. The high-frequency approach is illustrated using the example of a periodically driven Hubbard model. Moreover, we discuss the nature of the approximation and its limitations for systems of many interacting particles.
description: 48 pages, 7 figures
Relationship between 17-hydroxyprogesterone caproate concentrations and gestational age at delivery in twin gestation
Creators: name: Ramin, Susan M.
name: Peaceman, Alan M.
name: Simhan, Hyagriv N.
name: Varner, Michael W.
name: Harper, Margaret
name: Zhao, Yuan
name: Sorokin, Yoram
name: Lo, Julie
name: Malone, Fergal D.
name: Thorp, John M.
name: Rouse, Dwight J.
name: Carpenter, Marshall
name: Spong, Catherine Y.
name: Caritis, Steve N.
name: Mercer, Brian M.
name: Sciscione, Anthony
name: Iams, Jay D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: To evaluate in women with twin gestation the relationship between 17-hydroxyprogesterone caproate (17-OHPC) concentration and gestational age at delivery and select biomarkers of potential pathways of drug action.
Timing of delivery and pregnancy outcomes among laboring nulliparous women
Creators: name: Iams, Jay D.
name: Harper, Margaret
name: Ramin, Susan M.
name: Spong, Catherine Y.
name: Mercer, Brian M.
name: Sciscione, Anthony
name: Tita, Alan Thevenet N.
name: Malone, Fergal D.
name: Bloom, Steven L.
name: Caritis, Steve N.
name: Grobman, William A.
name: Thorp, John M.
name: Lai, Yinglei
name: Varner, Michael W.
name: Carpenter, Marshall W.
name: Sorokin, Yoram
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: To compare pregnancy outcomes by completed week of gestation after 39 weeks with outcomes at 39 weeks.
Lack of clinical AIDS in SIV-infected sooty mangabeys with significant CD4+ T cell loss is associated with double-negative T cells
Creators: name: Mir, K.D.
name: Brenchley, J.M.
name: Reeves, J.D.
name: Cole, K.S.
name: Cano, C.A.
name: Engram, J.
name: Gordon, S.N.
name: Hancock, K.
name: Sodora, D.L.
name: Milush, J.M.
name: Silvestri, G.
name: O'Neill, E.
name: Else, J.G.
name: Sundaravaradan, V.
name: Butler, E.
name: Anton, E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: SIV infection of natural host species such as sooty mangabeys results in high viral replication without clinical signs of simian AIDS. Studying such infections is useful for identifying immunologic parameters that lead to AIDS in HIV-infected patients. Here we have demonstrated that acute, SIV-induced CD4+ T cell depletion in sooty mangabeys does not result in immune dysfunction and progression to simian AIDS and that a population of CD3 +CD4-CD8- T cells (double-negative T cells) partially compensates for CD4+ T cell function in these animals. Passaging plasma from an SIV-infected sooty mangabey with very few CD4 + T cells to SIV-negative animals resulted in rapid loss of CD4 + T cells. Nonetheless, all sooty mangabeys generated SIV-specific antibody and T cell responses and maintained normal levels of plasma lipopolysaccharide. Moreover, all CD4- low sooty mangabeys elicited a de novo immune response following influenza vaccination. Such preserved immune responses as well as the low levels of immune activation observed in these animals were associated with the presence of double-negative T cells capable of producing Th1, Th2, and Th17 cytokines. These studies indicate that SIV-infected sooty mangabeys do not appear to rely entirely on CD4+ T cells to maintain immunity and identify double-negative T cells as a potential subset of cells capable of performing CD4+ T cell-like helper functions upon SIV-induced CD4+ T cell depletion in this species.
A prospective study of perinatal depression and trauma history in pregnant minority adolescents
Creators: name: Johnson, Nell
name: Bledsoe-Mansori, Sarah E.
name: Jackson, Christine
name: Killian, Candace
name: Hamer, Robert M.
name: Meltzer-Brody, Samantha
name: Wessel, Julia
name: Thorp, John
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Adolescent pregnancy is common and minority adolescents are at high risk. We sought the following: (1) to prospectively assess prevalence of antenatal depression (AND) and postpartum depression (PPD) in minority adolescents and (2) to examine the association of social support and adjustment, trauma, and stress on depression status.
Dirac semimetals $A_3Bi$ ($A$=Na,K,Rb) as $Z_2$ Weyl semimetals
Creators: name: Gorbar, E. V.
name: Miransky, V. A.
name: Shovkovy, I. A.
name: Sukhachov, P. O.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Theory (hep-th)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We demonstrate that the physical reason for the nontrivial topological properties of Dirac semimetals $A_3 Bi$ (A=Na,K,Rb) is connected with a discrete symmetry of the low-energy effective Hamiltonian. By making use of this discrete symmetry, we argue that all electron states can be split into two separate sectors of the theory. Each sector describes a Weyl semimetal with a pair of Weyl nodes and broken time-reversal symmetry. The latter symmetry is not broken in the complete theory because the time-reversal transformation interchanges states from different sectors. Our findings are supported by explicit calculations of the Berry curvature. In each sector, the field lines of the curvature reveal a pair of monopoles of the Berry flux at the positions of Weyl nodes. The $Z_2$ Weyl semimetal nature is also confirmed by the existence of pairs of surface Fermi arcs, which originate from different sectors of the theory.
description: 6 pages, 2 figures; published version with minor changes and an extended discussion
Advanced lipoprotein measures and recurrent preterm birth
Creators: name: Peaceman, Alan M.
name: Thorp, John M.
name: Iams, Jay D.
name: Ramin, Susan M.
name: Wapner, Ronald J.
name: Sciscione, Anthony
name: Harper, Margaret
name: Rouse, Dwight J.
name: Varner, Michael W.
name: Klebanoff, Mark
name: Sorokin, Yoram
name: Rice, Madeline Murguia
name: Mercer, Brian M.
name: Caritis, Steve N.
name: Anderson, Garland B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Lipoproteins are associated with atherogenic and inflammatory processes, and these processes may be related to adverse pregnancy outcomes. We therefore examined whether variations in lipoprotein particle size and concentration are associated with preterm birth (PTB) < 35 weeks’ gestation.