cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The phase space for the Einstein-Yang-Mills equations, black hole mechanics, and a condition for stationarity
Creators: name: McCormick, Stephen Michael
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: In this thesis, we study the phase space for the Einstein-Yang-Mills equations on an asymptotically flat manifold. The phase space is defined as a Hilbert manifold, which is modeled on weighted Sobolev spaces. We use an implicit function theorem argument to prove that the space of solutions to the constraint equations is a Hilbert submanifold of the phase space; this is equivalent to the statement that the Einstein-Yang-Mills constraints on an asymptotically flat manifold are linearisation stable. It is then shown that the energy, momentum, charge and angular momentum are smooth maps acting on the constraint submanifold. This framework allows us to prove that the first law of black hole mechanics provides a condition for initial data to be stationary, in two distinct cases: when the Cauchy surface has an interior boundary, and when it does not. Both cases are established using a Lagrange multipliers argument.
Alcohol congener analysis in a forensic context: detection of iso-α-acids to confirm beer consumption
Creators: name: Rodda, Luke Neil
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Alcohol abuse is a leading factor in many crimes and accidents with beer being the oldest and most widely consumed alcoholic beverage in the world. This research has focused on iso-α-acids (IAA) derived from the hop plant (Humulus lupulus L.) used in brewing and found in beer. Additionally, three structurally similar but chemically-altered IAA known as “reduced IAA” (rho-, tetrahydro- and hexahydro-IAA), are also beer-specific ingredient congeners found in beer, specifically used in green or clear bottled beer. A protein precipitation extraction and ESI-UHPLC-MS/MS method was developed and validated for the detection of these compounds in biological specimens that can confirm beer consumption. The long-term stabilities of these analytes in stored blood specimens was assessed over 8 weeks with freezing (-20 °C) and refrigeration (4 °C) conditions determined as acceptable. The analysis of blood and urine collected over 6 hours from volunteers given five different beers in five drinking studies separated by at least one week. The natural and reduced IAA were found to be bioavailable, show small inter-variable differences in concentration-time profile, and possess pharmacokinetic data such as quick absorption rates and half-lives ranging between ~30-46 minutes. Furthermore, in the assessment of 130 postmortem cases, ~57% of positive BAC cases showed beer consumption prior to death, and an even higher prevalence (87%) in casework where “beer” was mentioned in the case circumstances. Considerable postmortem redistribution, a serum to blood ratio of ~3 and a weak association between BAC and IAA groups was observed. Vitreous humour and urine specimens contained very low concentrations and prevalence of IAA groups. Lastly, the analytical method was used to assess the IAA profiles for over 30 different brown, green and clear bottled, local and international beers. This reference catalogue assists forensic toxicologists in comparing and interpreting the results of authentic and unknown casework. This novel approach can be used to provide important information on the drinking behaviour and circumstances surrounding after-drinking (hip-flask) defence cases and additional forensic applications such as coronial, drug facilitated sexual assault, research or clinical medico-legal casework. Thesis by publication is the primary structure of this PhD thesis with a total of seven peer-reviewed publications (three in review) resulting from this project that providing comprehensive knowledge for the use of this technique in forensic institutes locally and internationally.
Additional file 3: Table S2. of Conservation of polypyrimidine tract binding proteins and their putative target RNAs in several storage root crops
Creators: name: Kondhare, Kirtikumar
name: Kumar, Amit
name: Hannapel, David
name: Banerjee, Anjan
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology
subject: Virology

description: Gene-specific primers used for RT-qPCR. (PDF 106Â kb)
Verslag CRIS 2014 Rome
Creators: name: Wegh, Egon
Publisher: name: Zenodo
Year: 2019
Subjects: Current Research Information Systems (CRIS)
CRIS

description: Conference report of the conference CRIS (Current Research Information Systems) 2014 in Rome, that I attended in May of that year. The report is in Dutch and contains my personal notes on the sessions I attended.
Dispersion and confinement of multiwall carbon nanotubes in immiscible polymer blends
Creators: name: Poyekar, Amrita
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: A wide spectrum of applications of carbon nanotubes (CNTs) in specific engineering applications includes high performance materials in space applications, automotive applications, electronic devices, electromagnetic shielding (EMI) and electrostatic dissipative (ESD) materials. High L/D ratio and flexibility along with attractive forces between multiwall carbon nanotubes (MWNTs) surfaces manifest in highly ‘agglomerated’ structure of ‘as-received’ MWNTs. Incorporation of MWNTs in various polymer matrices has been exploited as a strategy to obtain electrically conducting composites with superior mechanical and thermal properties. CNTs pose issues during processing with polymer matrices, arising from ‘agglomeration’ and ‘entanglement’ of MWNTs, ‘slippage’ of nanotubes during deformation and, poor polymer/MWNTs interfacial interaction. It is therefore a challenging task to achieve a uniform dispersion of MWNTs in a polymer matrix through melt-mixing technique. In order to uniformly disperse MWNTs in immiscible polymer blends, it is necessary to enhance the extent of ‘debundling’ of MWNTs and selectively localize the MWNTs in one of the phases or at the interface. It is difficult to determine the state of dispersion of MWNTs in polymer matrices using a single characterization technique. Hence, the investigation of dispersion has been carried out at various length scales in order to study the overall state of dispersion of MWNTs in the polymer blend of polyamide 6 (PA6) and acrylonitrile butadiene styrene copolymer (ABS) with the help of novel organic non-covalent modifiers in combination with a suitable reactive compatibilizer. Thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy of the Indian Institute of Technology Bombay, India and Monash University, Australia.
On the role of doubly-diffusive mixing in low-mass red giant branch stars
Creators: name: Angelou, George Christopher
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: The purpose of this thesis is to investigate mixing in red-giant stars. Thanks particularly to the observations of globular clusters, it is clear that that standard stellar evolution fails to reproduce measured stellar abundances as a function of (red giant branch) luminosity. The empirical data has demonstrated that theorists are missing vital physics in their codes during this phase of evolution. Solutions to this problem have been postulated for many decades now, with mechanisms attributed (but not limited) to rotation, magnetic fields or internal gravity waves. A recently suggested instability, namely thermohaline mixing, serves as the focus of this investigation. It is caused by the competition between heat and chemical diffusion and is only possible due to the unique conditions following dredge-up events. Using observations of lithium and carbon we determine whether this mechanism and/or its current parameterisation can influence the surface composition of red giant branch stars. The quality of the data collected from the Very Large Telescope in Chile, some of which is gathered from our own observing programs, allows us to further constrain the mixing process(es)involved and improve the stellar models.
MOESM1 of Urine proteomics of primary membranous nephropathy using nanoscale liquid chromatography tandem mass spectrometry analysis
Creators: name: Pang, Lu
name: Li, Qianqian
name: Li, Yan
name: Liu, Yi
name: Duan, Nan
name: Li, Haixia
Publisher: name: figshare
Year: 2018
Subjects: Biochemistry
Space Science
Medicine
Pharmacology
Chemical Sciences not elsewhere classified
Marine Biology

description: Additional file 1: Table S1. Clinical characteristics of patients in group A.
Novel three-DOF reconfigurable spherical motion generator
Creators: name: Ip, Shiu Hang
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: A novel Reconfigurable Spherical Motion Generator (RSMG) is developed to provide continuous spherical motion and force transmission. Unlimited spherical motion is one of the challenges of flight simulators. RSMG is a prototype of flight simulator which achieves unlimited spherical motion. RSMG is a redundant parallel manipulator. There are four robotic arms attached onto the rotor surface in order to provide 3-DOF spherical motion. Every single robotic arm is reconfigurable such that singular configurations can be avoided by reconfigurability of RSMG. The conceptual design with concept-proof devices are built. The development of RSMG is presented including the problems solving in each prototypes. Direct and inverse kinematics are presented followed by singularity analysis of the mechanism. Dynamics of RSMG is presented. Actuation strategy is developed for the proposed manipulator to avoid serial singularity. RSMG is capable to avoid serial singularity and has potential to avoid parallel singularity based on the reconfigurability such that unlimited spherical motion can be achieved.
Additional file 4: Figure S2. of Conservation of polypyrimidine tract binding proteins and their putative target RNAs in several storage root crops
Creators: name: Kondhare, Kirtikumar
name: Kumar, Amit
name: Hannapel, David
name: Banerjee, Anjan
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Ecology
subject: Developmental Biology
subject: Plant Biology

description: Catalog and alignments of PTB1/6 types in five root crops species. (PDF 828Â kb)
Struttura AF11d per AFRODITE
Creators: name: Biscari, C.
Publisher: name: INFN Open Access Repository
Year: 1986
Subjects: ADONE
AFRODITE

description: È stata disegnata una struttura uguale alla AF11B eccetto nella lunghezza del drift D4, la quale è stata aumentata di 12 cm, per aggiungere lo spazio necessario alle bobine del magnete e del primo quadrupolo dell'inserzione.
Should statutory oppression remedies apply to unit trusts? A comparison of unitholder and shareholder rights
Creators: name: Bergman, Ari Braham
Publisher: name: Monash University
Year: 2019
Subjects: Uncategorized

description: This thesis analyses the case for amendments to be made to the Corporations Act 2001 (Cth) (‘the CA’) to afford Australian unitholders the same rights of recourse as Australian shareholders under statutory oppression remedies. Australian unit trusts and companies operate under similar commercial conditions, and the types of disputes that arise concerning shareholders and unitholders are comparable. However, there are distinct structural differences between unit trusts and companies that affect the legal principles that apply to such disputes. Given these differences, the unit trust structure may not adequately protect the interests of the venturers if the business relationship breaks down. One of the most common forms of dispute in such circumstances involves allegations of oppressive conduct. For companies, Part 2F.1 of the CA (which contains the statutory oppression remedies) can provide effective relief to oppressed shareholders. In contrast, unit trusts are predominantly subject to traditional trust law principles, which lack tailored oppression remedies that shareholders enjoy under Part 2F.1. In particular, this thesis demonstrates that the grounds for securing relief under trust law principles are more difficult for oppressed unitholders to establish. Even where such grounds are successfully established, the remedies available are often inadequate to provide substantive and effective relief to unitholders. Notwithstanding the CA has only limited jurisdiction over unit trusts (especially private unit trusts), oppressed unitholders have sometimes sought relief under Part 2F.1 in an attempt to access more effective remedies than those available under trust law. While a number of earlier decisions determined unitholders are entitled to relief under Part 2F.1, it is argued that the judicial grounds used to support such relief are debatable, therefore the status of the law remains unclear. In addition, several recent court decisions have rejected these earlier findings. Such contradictory decisions expose the abstruseness of the legislation in this area. Therefore, with inadequate protections against oppression afforded to unitholders under trust law, it is submitted there is a strong argument for legislative reform, ideally by extending the rights of unitholders to access statutory oppression remedies under Part 2F.1 of the CA.
The politics of decentralisation in Cambodia: the district level
Creators: name: Eng, Netra
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Decentralisation has been implemented by the Cambodian government with international donor support. Western aid donors expected that decentralisation would contribute to good governance and democratisation in Cambodia. This thesis examines the actual outcomes of decentralisation, particularly at the district level, since the first election of local councils at commune level in 2002. Through extensive interviews with elected councillors, appointed local administrators, officials in central government ministries, and representatives of non-governmental organisations and aid donors, the research investigates the ways in which the decentralisation programme has been understood, designed and implemented by the government and the ruling party – the Cambodian People’s Party (CPP). It also discusses the effects of decentralisation on future governance in Cambodia. Adopting a political economy approach to the study of decentralisation, the thesis argues that the donor-promoted decentralisation in Cambodia has been designed and implemented in a context where power has been successfully consolidated in the hands of the CPP and its informal patronage network within the bureaucracy, the armed forces and the private sector. Because of this, the decentralisation has helped keep the CPP in power and consequently has militated against the emergence of empowered and independent sub-national authorities operating according to rules-based governance. Thus, it has disappointed the goals envisaged by western donors. The CPP’s preferred mode of governance, combining predation and neo-patrimonialism, differs sharply from the Western aid donor prescriptions for good governance being promoted through decentralisation. In this context, the behaviour of local actors – local councils and the administration – who occupy the decentralised institutions, the authority and resources given to them, and the accountability relationships that are produced by elections and reform processes can best be understood as having been shaped by rather than challenging the pre-existing power hierarchy. Consequently, the thesis shows that there are unlikely to be democratic gains from decentralisation. The research further suggests that a significant shift of political and economic power from national level elites to local leaders closer to the people, necessary for decentralisation to achieve the goals intended by western donors, is not likely to occur. This state of affairs is expected to remain unchanged in the foreseeable future in spite of the CPP’s surprisingly poor performance in the July 2013 national election, when it won twenty-seven fewer seats in the National Assembly than in the 2008 election.
Mimicking self-similar Markov martingales and extensions
Creators: name: Fan, Jie Yen
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: As stochastic processes are not uniquely defined by their marginal distributions, it is of interest to construct different processes that match the marginal distributions of a given process — we call this mimicking process. In this thesis, we provide a construction scheme to mimic any self-similar, Markov, martingale process. Given such a process, we can construct a family of processes that are also self-similar and Markovian, and can be chosen to be martingales under certain condition. This mimicking can be done by randomising the transition function, or by time-changing the process together with an appropriate scaling. We obtain also the infinitesimal generator and some properties of the resulting processes. Some examples are also provided, together with the computations of the infinitesimal generators and the predictable quadratic variations of the resulting processes. We then extend our construction to mimic a broader class of processes, including some non-Markov processes.
MOESM2 of Urine proteomics of primary membranous nephropathy using nanoscale liquid chromatography tandem mass spectrometry analysis
Creators: name: Pang, Lu
name: Li, Qianqian
name: Li, Yan
name: Liu, Yi
name: Duan, Nan
name: Li, Haixia
Publisher: name: figshare
Year: 2018
Subjects: Biochemistry
Space Science
Medicine
Pharmacology
Chemical Sciences not elsewhere classified
Marine Biology

description: Additional file 2: Table S2. Clinical characteristics of patients in group B.
KREDIT-MODUL TIZIMI SHAROITIDA OLIY TA'LIMNI BAHOLASHNI  DIDAKTIK VAZIFALARI
Creators: name: Temirov, Abror
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqolada “Kredit-modul’ tizimi”, uning yurtimizda joriy etilishi va bunda kuzatilayotgan muammolar sharhi keltirilgan. Mazkur materialdan tegishli soha vakillari o‘zlari uchun nazariy manbaa sifatida foydalanishlari mumkin.
Perverting peacekeeping: the organisational accountability of the United Nations for sexual exploitation and abuse on peacekeeping operations
Creators: name: Nguyen, Athena Mai-Tram
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Allegations of sexual exploitation and abuse (SEA) have plagued peacekeeping operations for over a decade. Despite the United Nations (UN) extensive efforts to address the problem, acts of SEA continue to occur and cause great harm to victims and survivors, to the success of the peacekeeping operation, and to the reputation and credibility of the UN. Whilst the responsibility of the alleged perpetrator and of the State from which the perpetrator came have been considered in the literature, an area that has received less attention is the legal responsibility of the UN. In this thesis, this area of responsibility will be examined. The question will be asked: how can the organisational accountability of the UN be established for acts of SEA committed on its peacekeeping operations? To answer this question, this thesis will consider: first, whether acts of SEA are prohibited under international law and, therefore, whether these acts are a violation of international law; second, whether international organisations, such as the UN, have any obligations under international law; and, if so, if and how the UN may be held accountable for failing to uphold its obligations. In this thesis, it will be argued that the best international legal framework for the prohibition of acts of SEA is international human rights law. However, an analysis of the current legal system will demonstrate that it is difficult to hold the UN to account due to limitations in the personal and subject-matter jurisdiction of international, regional, and domestic judicial bodies. The unique contribution of this thesis will be to offer an alternative solution to establishing the organisational accountability of the UN. It will be proposed that the UN treaty bodies should be empowered with the competency to consider communications from individuals alleging a violation of their human rights through acts of SEA by UN personnel. The arguments presented in this thesis will outline: why the communications procedures of the UN treaty bodies are an effective process through which to resolve allegations of SEA; the legal and procedural changes that are needed to establish this process; the benefits for individual survivors, the UN, and the international community; and why this proposal is an effective, pragmatic, and economical solution to the problem of ensuring the organisational accountability of the UN for acts of SEA committed on its peacekeeping operations.
The McDonaldization of nursing education in Australia
Creators: name: Ralph, Nicholas
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Under the auspices of the Nursing and Midwifery Board of Australia (NMBA), the Australian Nursing and Midwifery Accreditation Council (ANMAC) was established in 2010 to set standards for and accredit programs of nursing education under the National Registration and Accreditation Scheme. The national accreditation process is central to promoting and protecting the health of the Australian community as it is the chief means of assessing whether a program of study and/or education provider affords a person who completes the program with the knowledge, skills and professional attributes necessary to register as a nurse in Australia. For such a significant undertaking, it is remarkable that the accreditation of nursing education and its impact on the design of undergraduate pre-registration nursing curricula is largely untouched in the literature. This research investigates the process of curriculum design in undergraduate nursing curricula and the role national accreditation plays in informing it. Grounded theory provides a methodological framework for this study that employs a variety of data sources including interviews and written correspondence with curriculum and accreditation stakeholders, along with documents relating to the accreditation process. By arriving at an explanatory theory of how curriculum design is conducted in the context of national accreditation processes, this study enhances the validity of the accreditation process and promotes quality in undergraduate nursing education across Australia.
Additional file 5: Table S3. of Conservation of polypyrimidine tract binding proteins and their putative target RNAs in several storage root crops
Creators: name: Kondhare, Kirtikumar
name: Kumar, Amit
name: Hannapel, David
name: Banerjee, Anjan
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Developmental Biology
subject: Plant Biology
subject: Virology

description: Cytosine/uracil motifs in the 3Â´ UTRs of BEL5- and POTH1-like mRNAs. (PDF 148Â kb)
Online counselling for problem gambling: an analysis of client and session characteristics
Creators: name: Rodda, Simone Nicole
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Increasingly, help and support are being delivered online for highly stigmatised disorders such as problem gambling. Although popular in terms of rate of uptake, there has been very limited investigation into who attends online counselling, why they attend, or the mechanisms of online counselling. Through five empirical studies using both quantitative and qualitative approaches, this thesis investigates the characteristics, readiness to change and motivations of individuals choosing online over other options. It then explores the mechanisms of online counselling in terms of the content of a counselling session and the character of the client-counsellor interaction. Online counselling participants were most often younger than 40 years of age, more often male and also gambled online. These participants reported high readiness to change but low confidence to manage a gambling urge. Approximately half of participants sought an intervention outside of a crisis situation. Primary motivations for using online counselling, rather than another counselling modality, were related to anonymity, convenience, ease of access and a preference for writing over talking. Participants reported positive session evaluations and immediate improvement in confidence and distress following a single online session. These findings indicate online counselling is attracting a new cohort of treatment seekers who report positive experiences of this new modality. To further advance the field, the effectiveness of a single online counselling session delivered in community settings and the mechanisms (e.g., interaction between client and counsellor, content of sessions) of online counselling need to be further understood. Targeted interventions that are delivered by a clinician have the potential to make a major contribution towards reducing the impact of problem gambling. Future online counselling enhancements could include interventions matched to client motivations for help-seeking and readiness to change.
MOESM3 of Urine proteomics of primary membranous nephropathy using nanoscale liquid chromatography tandem mass spectrometry analysis
Creators: name: Pang, Lu
name: Li, Qianqian
name: Li, Yan
name: Liu, Yi
name: Duan, Nan
name: Li, Haixia
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Marine Biology

description: Additional file 3: Table S3. Clinical characteristics of healthy volunteers in group C.
MyGene2 automated match report: WWOX
Creators: name: Team, The MyGene2
Publisher: name: figshare
Year: 2017
Subjects: subject: 110311 Medical Genetics (excl. Cancer Genetics)
subject: FOS: Basic medicine

description: MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If multiple MyGene2 profiles potentially match on a shared gene of interest, MyGene2 automatically generates a match report summarizing the information in these profiles. This automated match report is shared publicly to help facilitate further research and/or connections between the submitters of the MyGene2 profiles and other interested parties. This is an automated match report for WWOX.
Changing places an archaeological study of Manilikarr Country in Western Arnhem Land
Creators: name: Shine, Denis
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: This thesis examines how human connections to place, specifically between the Manilikarr clan and their estate in the East Alligator River region of western Arnhem Land, have changed during the Holocene. I focus on the later Holocene, in particular the period since regional freshwater wetlands formed, as it is this environment that retains ontological significance for local Aboriginal groups in the East Alligator River region today. Aboriginal connections with place are also more decipherable in archaeological horizons that are comparable and contiguous with ethnographic records, as is frequently the case for ‘freshwater’ archaeological sites of recent times. As Aboriginal people engaged with wetlands, they created both freshwater places and personhoods through symbiotic processes of inscription. Freshwater landscapes in the East Alligator River region were imbued with memories, meanings and social significance and became crucial to Aboriginal economic, ecological and cosmological structures. My research examines both when, and how, processes of co-inscription between people and place occurred, primarily through archaeological excavations at three rock-shelters in Manilikarr Country (Ingaanjalwurr, Birriwilk and Bindjarran). The results of these excavations, together with subsidiary evidence from ethnographic recordings, historical sources, rock art research, and palaeoenvironmental studies, indicate that ethnographically recalled Aboriginal engagements with, and significations of, the freshwater landscape in Manilikarr Country emerged within the past 700 years. Customary Aboriginal connections with the freshwater environment remain culturally relevant today, although they are increasingly compromised by cultural change. The impacts of Western worldviews continue to pose enduring challenges for customary engagements with Country, especially among younger generations. Such challenges mean that research like that presented in this thesis, which examines Ancestral-into-present relations between wetland landscapes and people, is of social, cultural and political significance considering contemporary risks posed by rapid social and environmental change. While members of Manilikarr Country ethnographically identified as ‘freshwater people’ and continue to do so today, senior members are keenly aware that decreasing engagements of younger generations with their Ancestral landscapes (as Country) threatens the longevity and future of their identity as freshwater peoples. It is these connections to place and Country that form the subject of this thesis.
Investigating the role of copper homeostasis in the nervous system of drosophila melanogaster
Creators: name: Hwang, Ern Ci Joab
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Copper is an essential trace metal required by multiple processes within the body, such as energy metabolism, neuropeptide maturation and pigmentation. However, excess copper is toxic to the body, and a homeostatic balance must be achieved using a set of copper homeostasis proteins which strictly control the concentration of copper in the body and in cells. While much research has been carried out into the general mechanisms of copper homeostasis, little is known about the specific roles of copper and copper homeostasis in various organs and tissues, such as the nervous system. This project has sought to use Drosophila melanogaster as an in vivo model to examine the role of copper homeostasis in the nervous system. I have found that pan-neuronal overexpression of the copper importer Ctr1B (resulting in cellular copper overload) causes lethality, while pan-neuronal overexpression of the copper exporter DmATP7 (resulting in cellular copper deficiency) causes both lethality and an unexpanded wing phenotype in surviving adults. I also have found that these phenotypes are sensitive to copper and BCS (a copper chelator) feeding. For example, feeding flies which overexpress Ctr1B pan-neuronally with BCS reduces cellular copper overload and rescues the lethality phenotype. I have found that copper overload causes damage to the cell, leading to cell death, and is the likely mechanism underlying the lethality phenotype observed. Further, I have found that copper deficiency in neuropeptidergic cells lead to failure of neuropeptide processing, resulting in the unexpanded wing defect. I have also used an in vivo system based on green fluorescent protein constructs to examine the effect of mutations on DmATP7 localization and function in different tissues, and have carried out a screen based on the pan-neuronal copper overload and deficiency phenotypes to screen for new players in copper homeostasis. Rab10 emerged as a candidate gene from this screen, and I have shown that Rab10 plays a role in copper homeostasis due to its requirement for proper localization of the copper transport proteins Ctr1A and DmATP7. Finally, this study provides evidence for cellular compartmentalization of the requirement for copper, that is, different pathways and compartments in the cell having different requirements for copper. For example, it is possible to generate situations where the lethality and the unexpanded wing phenotypes of flies overexpressing DmATP7 pan-neuronally respond differently to changes in copper homeostasis. Overall, this project has established Drosophila melanogaster as a valuable in vivo model for examining the role of copper in the nervous system.
Half a proposition for a banner march and a black cube hot air balloon
Creators: name: Ishak, Raafat
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Half a proposition for a banner march and a black cube hot air balloon is a broad proposition stimulated by a position of conflict grounded in binary interpretations of historical shifts, particularly in art and architecture. Specifically, this paper investigates and discusses the 1915 painting Black Square by Kazimir Malevich (1879-1935) and its relationship to Mecca’s black cube, the holy Kaaba in Saudi Arabia, implicating both venerable objects within a singular historical trajectory. The aim is to utilise both forms in a process of demarcation towards the creation and launch of a black cube shaped hot air balloon, the principle component of this research. The paper investigates the historical and social backgrounds of both objects in an act of overt sabotage of meanings and associations and a notional imploration to liberate the square. Furthermore, the paper will investigate the historical trajectory of crowds and stadium architecture, the proposed launching site for a black cube hot air balloon. In the west, tradition, which often connotes a static, irrational and culturally monolithic past, is often contrasted with the modern, which signifies a dynamic, rational and culturally pluralistic present. What seems like a linear shift from tradition to modern is arguably a construct of vested interests. There are no clear distinctions between these variances. Less so, when considering the specific implications of language in establishing a modernist political view of the world. The shift from tradition to post-industrial modernity was highlighted by the development of a specific language, contracting a cultural response to a colonised world with a workable theory of progress. My research principally proposes that Black Square was a decisive gesture in articulating a contentious space between indeterminate positions. The black cube hot air balloon is a propositional articulation of Malevich’s Black Square and the black cube of Mecca. It intends to amalgamate two diametrically opposed historical constructs for the purpose of realigning the interpretation of cultural objects and inflicting an inclusive reading of historical events. Greek Sophism appears as the most fundamental precedent for establishing an argument, which is potentially construed as a rejection of a traditional historical trajectory, yet, is inherently, by the nature of the forms it emulates, susceptible to alternative elucidations.
Additional file 1: of In-vivo study of osseointegration in Prestige LP cervical disc prosthesis
Creators: name: Lou, Jigang
name: Wang, Beiyu
name: Wu, Tingkui
name: Wu, Wenjie
name: Li, Huibo
name: Liu, Ziyang
name: Liu, Hao
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: The original data on the Micro-CT of the operative segments in a caprine cervical disc arthroplasty model. (DOCX 16 kb)
Additional file 1: of Guanxinning tablet for patients who switch from dual antiplatelet therapy to aspirin alone after percutaneous coronary intervention: study protocol forÂ a cluster randomized controlled trial
Creators: name: Li, Jingen
name: Ju, Jianqing
name: Chen, Zhuo
name: Liu, Jing
name: Lu, Fang
name: Gao, Rui
name: Xu, Hao
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Cell Biology
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: SPIRIT 2013 Checklist. (DOC 128 kb)
Active plasmonic mode guiding in semiconductor Schottky nanostructures
Creators: name: Wijesinghe, Thamani
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Plasmonics bring hopes to overcome the bandwidth limitation in interconnectors in integrated electronic circuits, which are not capable to cater the demand for high data bandwidths in the years to come. This study investigates the light propagation in Schottky junction based nanostructures to achieve lossless plasmonic waveguides. The thesis presents analytical explanations and numerical simulations of plasmonic mode guiding in various metal-semiconductor nanostructures by incorporating an amplification scheme to improve the mode propagation length and mode confinement. The proposed techniques will largely assist in designing low-loss plasmonic interconnects for integrated nanocircuits and highly sensitive compact plasmonic sensing devices.
Investigation of a novel subset of TNFR2 expressing regulatory T cell in lung diseases
Creators: name: Mohamud, Rohimah
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: The immune system in the lung employs various mechanisms to maintain and restore lung homeostasis and protect the host against exacerbated responses to various environmental stimuli. The existence of CD3+CD4+CD25+ regulatory T cells (Treg) that actively suppress the function of T effector cells (Teff) is a key mechanism by which the immune system limits inappropriate or excessive inflammatory responses. In acute and chronic airway inflammation (e.g. allergen induced airway inflammation), Teff secreted various pro-inflammatory cytokines including activin A, TGF-b, IL-4, IL-5 and IL-13 that skew immune response towards T helper 2 cells (Th2). Lung exposure to cytokine antagonist (e.g. biological factors such as follistatin that bind activin A) decreased lung inflammatory responses with an increase in Treg, reflecting the therapeutics effects of targeting pro-inflammatory cytokines. In acute lung injury [e.g. lipopolysaccharides (LPS)-induce acute lung injury], the immune response was skewed towards Th17 cells that secreted higher levels of IL-17 together with other pro-inflammatory cytokines such as TNF, IL-10 and IL-6. Excessive pro-inflammatory cytokines secreted in the lung modify lung equilibrium of Teff and Treg altering their characteristics (e.g. proliferative capacity and function) in that microenvironment. An imbalance in Treg/Teff ratios led to the induction of acute inflammatory responses (e.g. lung injury or allergic airway inflammation) that fully resolved a month after exposure to stimuli. After the inflammation resolved, Treg/Teff ratios returned to homeostatic levels. Lung exposure to inert engineered materials [polystyrene 50 nm nanoparticles (PS50G)] did not only induce lung immune activation, however it also pre-conditioned for an increase in the frequency and the suppressive capacity of lung TNFR2 expressing Treg (i.e. increased the levels of suppressor molecules). Experimental data suggests that lung exposure to bacterial products (e.g. LPS) and PS50G protects individuals from developing allergic airway inflammation. PS50G facilitated an increase in the quantity and quality of lung TNFR2 expressing Treg which were perfectly positioned to respond rapidly to allergenic challenges and restored lung immune homeostasis. Therefore, targeting highly bioactive TNFR2 expressing Treg poses a new therapeutic avenue to promote healthy lung homeostasis. Overall, the novel findings of the effects of follistatin, LPS and engineered PS50G on TNFR2 expressing Treg may increase the chances that these stimuli will translate to new generic treatment for lung inflammation, particularly allergic diseases.
Double-stranded DNA as a model polymer: validation through rheological characterization
Creators: name: Pan, Sharadwata
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Solutions of double-stranded DNA (ds-DNA) have been investigated in the presence of excess salt to represent a model neutral polymer system. However, very recently, there have also been some contrary discussions regarding the suitability of using ds-DNA as a model polymer, based on scaling arguments and simulations. Here, we report systematic experimental investigations of dilute and semidilute unentangled ds-DNA solutions, to test the hypothesis that ds-DNA is a model polymer. In addition, we have meticulously characterized the behaviour of ds-DNA solutions far from equilibrium, in shear and extensional flows. In order to study the behaviour of ds-DNA to compare with well known results from neutral polymers, we first characterize its solutions close to equilibrium. We use the solvent quality parameter z and the dimensionless concentration c/c* (where c* is the overlap concentration), as the scaling variables. We have determined the Theta-temperature of DNA in Tris-EDTA buffer under excess salt conditions to be around 15 degree Celsius, and provide the formula to determine z for DNA of any molecular weight at any temperature above the theta temperature. We also show that the temperature crossover for dilute DNA solutions of various molecular weights (from 2.9 to 289 kilobasepairs) for the second virial coefficient, the hydrodynamic radius and the viscosity radius agree with the scaling behaviour of neutral synthetic polymers. The scaling behavior of the zero shear rate viscosity of semidilute DNA solutions, in the double crossover regime driven by temperature and concentration, is shown to have a power law dependence on the scaled concentration c/c*, with an effective exponent that depends on z, in agreement with reported Brownian dynamics simulations of flexible polymer chains. Away from equilibrium, in shear flow, the shear rate dependence of viscosity for semidilute and dilute DNA solutions, at various temperatures and concentrations, can be collapsed onto master curves when interpreted in terms of a different relaxation time based Weissenberg number. In extensional flow, the concentration dependence of the steady state uniaxial extensional viscosities of semidilute DNA solutions has been studied and compared with theoretical predictions. The material functions obtained in this work will also provide benchmark data that are useful for the characterization of industrially important semidilute systems. Equilibrium rheological characterization carried out on dilute and semidilute DNA solutions, investigated under excess salt conditions, show a remarkable agreement with other neutral synthetic polymers, asserting that DNA can be used as a model polymer for rheological studies. Thesis submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy of the Indian Institute of Technology Bombay, India and Monash University, Australia.
title: Transcription du manuscrit de Semur-en-Auxois, Bibliothèque Municipale, ms. 1, p. 62
Creators: name: Aubert, Eduardo Henrik
name: Brochard, Pierre
name: Aubert, Eduardo Henrik
name: Brochard, Pierre
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: subject: Laboratoire de médiévistique occidentale de Paris
subject: Semur-en-Auxois
subject: LaMOP

description: Transcription du manuscrit de Semur-en-Auxois, Bibliothèque Municipale, ms. 1, p. 62

production-software: eScriptorium + Kraken version 3.0.13 (PageXml)
description: Source: https://www.nakala.fr/10.34847/nkl.ce0al5v7
description: Source: https://www.nakala.fr/10.34847/nkl.e905tdea
description: Relation: https://lamop.hypotheses.org/
description: Transcription du manuscrit Semur-en-Auxois, Bibliothèque Municipale, ms. 1
description: Transcription du manuscrit Semur-en-Auxois, Bibliothèque Municipale, ms. 1
Modeling the first activation stages of a Fe(II) CVD precursor on a heated growth surface
Creators: name: Tabacchi, Gloria
name: Fois, Ettore
name: Barreca, Davide
name: Carraro, Giorgio
name: Gasparotto, Alberto
name: Maccato, Chiara
Publisher: name: figshare
Year: 2017
Subjects: subject: 30301 Chemical Characterisation of Materials
subject: FOS: Chemical sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: 30602 Chemical Thermodynamics and Energetics
subject: 30603 Colloid and Surface Chemistry
subject: Computational Chemistry
subject: Inorganic Chemistry
subject: 30299 Inorganic Chemistry not elsewhere classified
subject: 30302 Nanochemistry and Supramolecular Chemistry
subject: 39904 Organometallic Chemistry
subject: 30699 Physical Chemistry not elsewhere classified
subject: 30304 Physical Chemistry of Materials
subject: 30701 Quantum Chemistry
subject: 30306 Synthesis of Materials
subject: 30799 Theoretical and Computational Chemistry not elsewhere classified
subject: 30307 Theory and Design of Materials
subject: 30207 Transition Metal Chemistry
subject: 30607 Transport Properties and Non-equilibrium Processes
subject: Computational Physics
subject: 20403 Condensed Matter Modelling and Density Functional Theory
subject: FOS: Physical sciences
subject: Condensed Matter Physics
subject: 20499 Condensed Matter Physics not elsewhere classified
subject: 20406 Surfaces and Structural Properties of Condensed Matter
subject: 100706 Nanofabrication, Growth and Self Assembly
subject: FOS: Nanotechnology
subject: 100707 Nanomanufacturing
subject: 100708 Nanomaterials
subject: 100799 Nanotechnology not elsewhere classified

description: Green open access version of the paper:"Modeling The First Activation Stages of the Fe(hfa)2 TMEDA CVD Precursor on a Heated Growth Surface"
published in:Ceramic Engineering and Science Proceedings (2016) 36(6):83 - Advanced Processing and Manufacturing Technologies for Nanostructured and Multifunctional Materials II: A Collection of Papers Presented at the 39th International Conference on Advanced Ceramics and Composites (eds T. Ohji, M. Singh and M. Halbig), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781119211662.ch10
Which should be cited to refer to this work.
A popular summary of this paper is available at this link: https://goo.gl/MpdOpn
MOESM1 of Deep sustained response to daratumumab monotherapy associated with T-cell expansion in triple refractory myeloma
Creators: name: Usmani, Saad
name: Khan, Imran
name: Chiu, Christopher
name: Foureau, David
name: Druhan, Lawrence
name: Rigby, Katherine
name: Casneuf, Tineke
name: Sasser, A.
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Computational Biology

description: Additional file 1: Table S1. Antibodies used for flow cytometryâ based minimal residual disease assay and immune phenotyping. Table S2. Configuration of BD FACSAria II for minimal residual disease analysis.