cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Design, synthesis, molecular modeling, and biological evaluations of novel chalcone based 4-Nitroacetophenone derivatives as potent anticancer agents targeting EGFR-TKD
Creators: name: Mir, Showkat Ahmad
name: Murmu, Narayan
name: Meher, Rajesh Kumar
name: Baitharu, Iswar
name: Nayak, Binata
name: Khan, Andleeb
name: Khan, Mohammad Imran
name: Abdulaal, Wesam H.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biophysics
Biochemistry
Cell Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: A series of chalcone-based 4-Nitroacetophenone derivatives were designed and synthesized by the single-step condensation method. These compounds were identified by 1H NMR,13C NMR, MS, and FTIR analysis. Further, the derivatives were evaluated against four cancer cell lines H1299, MCF-7, HepG2, and K526. The IC50 value of potent compounds NCH-2, NCH-4, NCH-5, NCH-6, NCH-8, and NCH-10 was 4.5–11.4 μM in H1299, 4.3–15.7 μM in MCF-7, 2.7–4.1 μM in HepG2 and 4.9–19.7 μM in K562. To assess the toxicity against healthy cells all potent molecules were evaluated against the HEK-293T cell line, and IC50 values exhibited by NCH-2, and NCH-3 were 77.8, 74.3, and other molecules showed IC50 values > 100 μM. The EGFR expression was determined by using rabbit anti-EGFR monoclonal antibody and significant EGFR expression was knocked down observed in H1299 treated with NCH-10 as well as erlotinib. The underlying mechanism behind cell death was investigated through bioinformatics. First, the molecules were optimized and docked to the binding site of the EGFR kinase domain. The best complexes were simulated for 100-ns and compounds NCH-2, NCH-4, and NCH-10 achieved stability similar to the erlotinib bound kinase domain. The free energy binding (ΔGbind) of NCH-10 was found to be more negative −226.616 ± 2.148 kJ/mol calculated by Molecular Mechanics Poisson Boltzmann’s Surface Area (MM-PBSA) method. Both in vitro and in silico results conclude that the present class of chalcone-based 4-Nitroacetophenone derivatives are potent anti-cancer agents targeting EGFR-TKD and are 39 folds more effective against H1299, MCF-7, HepG2, and K562 carcinoma cell lines than healthy HEK-293T cell lines.
Experiencias de proyectos de investigación en Guardalavaca y Gibara para la transformación sostenible de destinos turísticos
Creators: name: Justa Ramona Medina Labrada
Publisher: name: Zenodo
Year: 2025

description: La COVID 19 aceleró cambios que se venían produciendo en la gestión turística a nivel internacional, entre ellos la gestión de destinos turísticos, enfocada en la actualidad con el nuevo paradigma de los destinos turísticos inteligentes, que se sustenta en la gestión de cinco ejes fundamentales: desarrollo sostenible, innovación, impulso a la accesibilidad universal, gobernanza turística y una infraestructura tecnológica de vanguardia. En este contexto se llevan adelante los proyectos de investigación “Desarrollo turístico inteligente y sostenible del destino Guardalavaca” desde 2023 y “Desarrollo turístico sostenible e inteligente del destino Gibara” desde 2024, en los cuales se han propuestos metodologías cubanas a partir de las mejores experiencias internacionales para la gestión de cada uno de los ejes. Su aplicación en Guardalavaca permitió proponer a los gestores turísticos estrategias de gobernanza y para la transformación digital del destino y planes de acción para la gestión de la innovación comercial, de la sostenibilidad del destino y para incrementar la accesibilidad de las organizaciones presentes en Guardalavaca, que están en proceso de implementación en estos momentos. En el caso de Gibara se diseñan productos turísticos rurales, náuticos y de ciudad, se estudia la percepción de la población local sobre el desarrollo del turismo y se gestan proyectos de desarrollo local, en función de incrementar los flujos turísticos y la competitividad de dicho destino.

 

Palabras clave: destino turístico inteligente, desarrollo turístico sostenible, proyectos de investigación, innovación comercial, accesibilidad universal.
Additional file 1 of Comprehensive DNA methylation profiling by MeDIP-NGS identifies potential genes and pathways for epithelial ovarian cancer
Creators: name: Gautam, Priyanka
name: Gupta, Sameer
name: Sachan, Manisha
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 1
ZAMONAVIY HUQUQIY BILISH RIVOJIDA TANQIDIY TAFAKKURDAN SAMARALI FOYDALANISHNING IJTIMOIY-MADANIY OMILLARI
Creators: name: Nuritdinov, Navruz
Publisher: name: Zenodo
Year: 2024

description: Zamonaviy huquqiy bilimni rivojlantirishda tanqidiy fikrlashdan samarali foydalanishda ijtimoiy-madaniy omillarning ahamiyati katta. Bu omillar huquqshunoslar va olimlarning muammolarga yondashish, qonunlarni sharhlash va yechimlarni amalga oshirish usullarini shakllantiradi. Ushbu maqolada zamonaviy huquqiy bilish rivojida tanqidiy tafakkurdan samarali foydalanishning ijtimoiy-madaniy omillari yoritilgan.
Evaluation of mutations on O6-methylguanine methyl transferase structure and its interactions: molecular dynamics simulation study
Creators: name: Gharouni, Marzieh
name: Mosaddeghi, Hamid
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biophysics
Biochemistry
Molecular Biology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: O6-methylguanine DNA methyl transferase (MGMT) is a significant vehicle for the cellular clearance of alkyl lesions, particularly the methyl group of the O-6 and O-4 positions of guanine and thymine, respectively. Many publications have studied the correlation between polymorphisms in MGMT and susceptibility to various cancers. In the present study, we investigated the consequence of L84F, common single-nucleotide polymorphism, K125E, site-specific mutagenesis, and L84F/K125E on conformation, stability, and behavior of MGMT in the free form and interaction with proliferating cell nuclear antigen (PCNA) and DNA as partners in the biochemical network by using molecular dynamics simulation method. Our results showed that all free variants of MGMT differed from the native form. However, among all free variants of MGMT, the L84F/K125E variant exhibited similar properties compared with the wild-type. In contrast, in complex modes, only amino acid residues of the L84F variant are involved in the interactions with PCNA and DNA somewhat differently relative to the wild-type. Furthermore, L84F SNP showed the highest binding free energy compared to other variants and native forms. These alterations in the amino acids and binding free energy of L84F relative to the native are the reasons for changing its region connection compared to the native form. Therefore, we propose conducting further investigations into the impact of inhibitors or chemotherapeutic agents to assess their effectiveness on MGMT variants compared to the wild-type, aiming to reduce the cost of cancer treatment that will depend on inhibiting native MGMT protein.
sj-pdf-1-act-10.1177_17483026211008414 - Supplemental material for On the simplex, interior-point and objective space approaches to multiobjective linear programming
Creators: name: Nyiam, Paschal B
name: Salhi, Abdellah
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies

description: Supplemental material, sj-pdf-1-act-10.1177_17483026211008414 for On the simplex, interior-point and objective space approaches to multiobjective linear programming by Paschal B Nyiam and Abdellah Salhi in Journal of Algorithms and Computational Technology
การวิเคราะห์คุณภาพการให้บริการของหน่วยงานคลัง คณะวิทยาศาสตร์ประยุกต์ มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ โดยใช้เครื่องมือประเมินคุณภาพ "SERVQUAL"
Creators: name: เพ็ญศรี ชื่นชม
Publisher: name: มหาวิทยาลัยมหาสารคาม
Year: 2559
Subjects: คุณภาพการให้บริการ, หน่วยงานคลัง คณะวิทยาศาสตร์ประยุกต์

description: วารสารสาระคาม มหาวิทยาลัยมหาสารคาม, 7, 2
Additional file 1 of Psychological distress and musculoskeletal pain in manual therapists during the second wave of the COVID-19 pandemic in Sweden: a cross-sectional study
Creators: name: Weiss, Nathan
name: Skillgate, Eva
name: Axén, Iben
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Mental Health

description: Additional file 1: Table S1: Description of the variables included; Table S2. Characteristics of participants included in the analyses and eligible participants (source population) and results from χ2 test and independent samples t-test presented as p-values.
การจัดการทรัพยากรมนุษย์ : ขอบข่ายและกระบวนการ
Creators: name: สัญญา เคณาภูมิ
Publisher: name: มหาวิทยาลัยมหาสารคาม
Year: 2559
Subjects: ทรัพยากรมนุษย์, การจัดการ

description: วารสารสาระคาม มหาวิทยาลัยมหาสารคาม, 7, 2
Mwes And The Emotion Lexicon: Typological And Cross-Lingual Considerations
Creators: name: Fotopoulou, Aggeliki
name: Giouli, Voula
Publisher: name: Zenodo
Year: 2018

description: The work presented in this paper is aimed at studying predicates that pertain to

the semantic field of emotions, the focus being on Modern Greek verbal multiword

expressions (verbal MWEs) and their counterparts in French. A core lexicon of ver-

bal MWEs denoting emotion was extracted from existing Modern Greek lexical

resources; the initial list was further extended and revised manually in view of cor-

pus evidence. A classification of MWEs is proposed based on syntactic, selectional

and semantic properties; an attempt to map the expressions identified onto their

French counterparts was also made. The cross-linguistic study reveals similarities

and discrepancies in the two languages, and highlights the interaction between

MWEs structure and their underlying semantics, in that the intensity of the emo-

tion denoted and the degree of fixedness of the relevant expressions seem to be

highly correlated in both languages.
Additional file 1 of Assessment of urban greenhouse gas emissions towards reduction planning and low-carbon city: a case study of Montreal, Canada
Creators: name: Pashaei, Shadnoush
name: An, Chunjiang
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1. Supplementary tables and figures.
Flexibility Of Multiword Expressions And Corpus Pattern Analysis
Creators: name: Hanks, Patrick
name: El Maarouf, Ismail
name: Oakes, Michael
Publisher: name: Zenodo
Year: 2018

description: This chapter is set in the context of Corpus Pattern Analysis (CPA), a technique

developed by Patrick Hanks to map meaning onto word patterns found in corpora.

The main output of CPA is the Pattern Dictionary of English Verbs (PDEV), cur-

rently describing patterns for over 1,600 verbs, many of which are acknowledged to

be multiword expressions (MWEs) such as phrasal verbs or idioms. PDEV entries

are manually produced by lexicographers, based on the analysis of a substantial

sample of concordance lines from the corpus, so the construction of the resource

is very time-consuming. The motivation for the work presented in this chapter is

to speed up the discovery of these word patterns, using methods which can be

transferred to other languages. This chapter explores the benefits of a detailed con-

trastive analysis of MWEs found in English and French corpora with a view on

English-French translation. The comparative analysis is conducted through a case

study of the pair (bite, mordre), to illustrate both CPA and the application of sta-

tistical measures for the automatic extraction of MWEs. The approach taken in

this chapter takes its point of departure from the use of statistics developed ini-

tially by Church & Hanks (1989). Here we look at statistical measures which have

not yet been tested for their ability to discover new collocates, but are useful for

characterizing verbal MWEs already found. In particular we propose measures to

characterize the mean span, rigidity, diversity, and idiomaticity of a given MWE.
The Evolution Of Differential Object Marking In Alor-Pantar Languages
Creators: name: Klamer, Marian
Publisher: name: Zenodo
Year: 2018
Subjects: Timor-AP languages
diachronic change in DOM
DOM
triggers
DOM in verbal agreement

description: This paper investigates the evolution of Differential Object Marking (DOM) in Abui and

Teiwa, two Papuan languages of the Alor-Pantar family in Eastern Indonesia. In both lan-

guages, reflexes of the same proto-morpheme are used in the differential marking of P (the

non-agentive argument in transitive constructions), but the languages contrast in the way

Ps are differentiated. We compare the synchronic DOM patterns of Abui and Teiwa with

each other as well as with the DOM patterns we reconstruct for their shared ancestor. We

establish how different patterns of DOM in this family have evolved over time, and which

semantic and morphological changes occurred in the process.

In their morphological expression, there are two strategies by which P’s are differentiated:

(i) the asymmetrical strategy involves an opposition between P as either a verbal prefix or

a free nominal, and (ii) the symmetrical strategy where the choice of a P-prefix is variable

depending on the semantics of P. Both strategies are used in both Teiwa and Abui, but the

symmetrical strategy involves a choice between two different prefixes in Teiwa and five

different prefixes in Abui.

Different factors trigger DOM in both languages: in Teiwa it is mostly based on the inherent

properties (animacy) of P, while in Abui there are many other triggers besides the animacy

of P, including the affectedness relation between the action and the P referent and the in-

flectional class of the verb. Furthermore, Abui has developed an extra, third, formal strategy

to differentiate human Ps from non-human ones in a serial verb construction.

The alignment system we reconstruct for the proto-language was semantic. It evolved into

an accusative alignment system in Teiwa, but was retained and further complexified in Abui.

Alignment systems are not static: their forms and triggers may be modified and complexified

over time.
Soziokultur: Kultur Als Handlungsfeld Der Soziokultur
Creators: name: Bauer, Dominique Suzanne
name: Iten, Isabel
Publisher: name: Zenodo
Year: 2008
Subjects: subject: gnd:4721392-9
subject: gnd:4073868-1
subject: gnd:4005895-5
subject: gnd:4042203-3
subject: gnd:4053881-3

description: Die Niederlande verfügt über eine äusserst aktive Kulturszene. Im Gegensatz zur Schweiz sind Soziokulturelle Animatorinnen und Animatoren darin solide verankert. Diese Annahmen waren ausschlaggebend für unsere Forschungsarbeit, die wir in der Schweiz und in den Niederlanden durchgeführt haben, mit der Absicht, unsere soziokulturelle Sichtweise zu erweitern.

Nach der Klärung von zentralen Begriffen und der Bildung eines eigenen Kulturverständnisses für diese Bachelorarbeit wird spezifisch auf die Soziokulturelle Animation in der Kulturarbeit eingegangen. Im Weiteren werden wesentliche Fakten der kulturpolitischen Rahmenbedingungen der Schweiz und der Niederlande beleuchtet. Die Ergebnisse der Interviews mit Expertinnen und Experten aus beiden Ländern zeigen auf, welche Tätigkeitsbereiche sich Soziokulturellen

Animatorinnen und Animatoren im Handlungsfeld der Kultur bieten, welche Funktionen sie dabei wahrnehmen können und über welche Kompetenzen sie verfügen sollten. Anhand eines speziellen Leitfadens werden spezifische Schlussfolgerungen

für die berufliche Praxis von Soziokulturellen Animatorinnen und Animatoren im Handlungsfeld der Kultur abgeleitet.

Der Ländervergleich zwischen der Schweiz und der Niederlande eröffnet neue Perspektiven für die Berufsentwicklung in der Soziokulturellen Animation im besagten Handlungsfeld. Er regt eine spannende Diskussion an über die kulturpolitischen Rahmenbedingungen, das Berufsbild sowie den Schwerpunkt «Kunst & Kultur» der untersuchten

Ausbildungsstätten in Luzern und Amsterdam.
description: + Code Diss LU: hslusa bask 2008
+ Fussnote: Bachelor-Arbeit, Hochschule Luzern - Soziale Arbeit, Ausbil-dungsgang Sozialarbeit, 2008
title: Tide and water level requirements for short-term tide stations and hydrographic surveys: specifications and deliverables
Creators: name: NOAA Center for Operational Oceanographic Products & Services
Publisher: name: NOAA Center for Operational Oceanographic Products & Services
publisherIdentifier: https://ror.org/05vcng590
publisherIdentifierScheme: ROR
Year: 2025

description: NOAA technical report NOS CO-OPS ; 113
description: The Office of Coast Survey (OCS) maintains a technical document known as the Hydrographic Survey Specifications and Deliverables (HSSD). This technical document provides OCS members and contractors a detailed description of everything related to hydrographic surveying. In the past, OCS would request the Center for Operational Oceanographic Products and Services (CO-OPS) support to maintain and update chapter 4 titled Tides and Water Level Requirements. However, for FY2023, OCS streamlined the HSSD and ultimately removed chapter 4. In order to prevent the loss of information, CO-OPS extracted chapter 4 from the HSSD 2022 and created this document. The specs contained have been updated to reflect current technical specifications for short-term stations and will be used by CO-OPS members, partners, and contractors to understand those specific requirements laid forth in this document. This document will not be updated in the future when technical specifications are changed or newly established.
Turismo gerontológico y envejecimiento saludable: fundamentos para un recorrido turístico alternativo en la ciudad de Camagüey
Creators: name: Jorge Anniel Ruiz Acosta
name: Ana María Ramos Monteagudo
name: Mirtha Juliana Yordi García
Publisher: name: Zenodo
Year: 2025

description: El envejecimiento demográfico es un fenómeno mundial que se ha expresado de manera exponencial desde inicios del presente siglo. Cuba se sitúa entre los países de mayor envejecimiento demográfico en Latinoamérica y ello impone una serie de desafíos al Estado en ámbitos tales como: la salud, la economía, la educación, los servicios de atención y cuidados y el turismo entre otros.

Con el aumento del grupo de personas de 60 y más años se ha promocionado el llamado turismo gerontológico, que promueve diversos productos turísticos dirigidos a personas mayores. No obstante, es preciso considerar el enfoque del envejecimiento activo y saludable en la promoción de un turismo sostenible, amigable para todas las edades.

A partir del análisis documental, la aplicación de encuestas a personas mayores y la consulta de expertos se propone un recorrido turístico como alternativa viable para estimular el turismo gerontológico, activo y saludable en la ciudad de Camagüey.

Se resalta la importancia de promocionar recorridos turísticos acordes a las necesidades de ocio, participación, entendimiento, protección y creación, como aspectos claves para el bienestar de las personas mayores en concordancia con los objetivos de la Agenda 2030 para el desarrollo. La propuesta es una contribución a la promoción de un turismo sostenible que promocione sus productos en correspondencia no sólo con las tendencias del mercado; los nuevos marcos jurídicos, institucionales y de gobernanza sino también con los cambios demográficos que acontecen en el mundo.

 

Palabras claves: Turismo gerontológico, envejecimiento saludable, personas mayores, recorrido turístico.
Pharmaceutical manifestation of Knoevenagel condensed metal (II) complexes through virtual, in vitro and in vivo assessments
Creators: name: Michael, Samuel
name: Jeyaraman, Porkodi
name: Marimuthu, Bhuvaneswari
name: Rajamanikam, Rajasekar
name: Thanasamy, Radha
name: Kumar, Karuppiah Arunsunai
name: Mitu, Liviu
name: Raman, Natarajan
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Pharmacology
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Sulphur containing compounds possess a great deal of interest due to wide range of beneficial activities towards biotic species. This work also deals with the study of biological examination of newly synthesized sulphur containing Cu(II) and Zn(II) complexes derived from (E)-4-(phenylimino)-3-((E)-1-(phenylimino)ethyl)pent-2-ene-1-thiol Schiff bases. Moreover, the DNA nuclease efficiency of the synthesized metal complexes is studied by UV absorption studies, Fluorescence studies, Viscosity and CV titrations which confirm the intercalative mode of binding. Pharmacokinetic studies and drug like activity of these compounds are screened with the help of SWISS ADME online freeware. Their morphological nature is corroborated by various spectral techniques. Optimized geometry and biologically accessible nature of the synthesized compounds are investigated by Gaussian 09 W software. Interestingly, molecular docking studies are carried out against cancer DNA and 6J10 cancer cell. Anti–inflammatory and in vitro antioxidant activities have been studied to validate the theoretical prediction. Based on these preliminary pharmacological activities, the in vitro cytotoxicity and in vivo antitumor activities are examined using MCF-7, HeLa, Hep-2, HepG-2 and Ehrlich ascites carcinoma (EAC) cell lines. All the above examinations reveal that the nitro substituted transition metal complexes possess higher biological bustle. Cu(II) and Zn(II) complexes incorporating Knoevenagel β-diketimine Schiff bases The quantum mechanical examinations using Gaussian 09W software Investigation of possible interactions with DNA by Molecular docking studies In silico, in vitro and in vivo analyses of the synthesized compounds
sj-pdf-5-wso-10.1177_17474930211052816 - Supplemental material for Posterior circulation stroke due to vertebral artery disease in the Chinese population
Creators: name: Zhang, Changqing
name: Li, Zixiao
name: Liu, Liping
name: Pu, Yuehua
name: Zou, Xinying
name: Yan, Hongyi
name: Pan, Yuesong
name: Zhao, Xingquan
name: Wang, Yilong
name: Wang, Yongjun
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Cardiology
subject: Medicine
subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-5-wso-10.1177_17474930211052816 for Posterior circulation stroke due to vertebral artery disease in the Chinese population by Changqing Zhang, Zixiao Li, Liping Liu, Yuehua Pu, Xinying Zou, Hongyi Yan, Yuesong Pan, Xingquan Zhao, Yilong Wang and Yongjun Wang in International Journal of Stroke
การศึกษาปัญหาและความต้องการในการทำโครงงานพิเศษของนักศึกษาภาควิชาเทคโนโลยีอุตสาหกรรมเกษตร อาหารและสิ่งแวดล้อม คณะวิทยาศาสตร์ประยุกต์ มหาวิทยาลัย เทคโนโลยีพระจอมเกล้าพระนครเหนือ
Creators: name: อัจจิมา สมท่า
Publisher: name: มหาวิทยาลัยมหาสารคาม
Year: 2559
Subjects: ปัญหาในการทำโครงงานพิเศษ, ความต้องการในการทำโครงงานพิเศษ

description: วารสารสาระคาม มหาวิทยาลัยมหาสารคาม, 7, 2
Jugendtreff Fussballstadion: Wie Aktives, Kreatives Fanverhalten Gestärkt Werden Kann
Creators: name: Kayser, Kathrin
name: Mettler, Colette
name: Widmer, Jürg
Publisher: name: Zenodo
Year: 2008
Subjects: subject: gnd:4131123-1
subject: gnd:4028863-8
subject: gnd:4036733-2
subject: gnd:4053881-3

description: Die Bachelorarbeit „Jugendtreff Fussballstadion“ befasst sich mit Einflussfaktoren, die ein aktives, kreatives Fanverhalten jugendlicher Fussballfans begünstigen. Jugendliche befinden sich in der Lebensphase der Adoleszenz, welche hohe Anforderungen an die Entwicklung der Heranwachsenden stellt. Die Resilienzforschung zeigt verschiedene individuelle und soziale Ressourcen, die die Jugendlichen in ihrer Entwicklung stärken. Die Ergebnisse aus der quantitativen Umfrage bei den Fans zeigen, dass die Lebenswelten Individuum, Familie, Peergroup, Paarbeziehung, Schule und Beruf sowie der Fanclub für jugendliche Fans relevant sind. Die spezifischen Verhältnisse der Lebenswelten beeinflussen die Entwicklung und das Verhalten der jugendlichen Fans. Dieser Umstand wird in Leitfadeninterviews mit Fanarbeitenden thematisiert. Dabei liegt der Fokus darauf, welche Einflussfaktoren als Risikio- und welche als Schutzfaktoren zu gewichten sind. Denn Einflussfaktoren können auf das Individuum sowohl schützen wie auch gefährden. Die jugendlichen Fussballfans sind gefordert, ein Gleichgewicht zwischen diesen Faktoren herzustellen, um anstehende Entwicklungsaufgaben meistern zu können und aktives, kreatives Fanverhalten aufzuweisen. Um das Verhalten der Fans zu erklären, nehmen wir einen lebensweltorientierten Fokus ein. Auch die Fanarbeit, die als Akteur der Sozialen Arbeit im Stadion agiert, wird aufgefordert, einen lebensweltorientierten Blick einzunehmen um aktives, kreatives Fanverhalten zu fördern. Zudem wird die interinstitutionelle Zusammenarbeit zwischen verschiedensten Organisationen aus den Lebenswelten und der Fanarbeit gefordert - zum Wohle der Jugendlichen und des Sports.
description: + Code Diss LU: hslusa basa 2008 be
+ Fussnote: Bachelor-Arbeit, Hochschule Luzern - Soziale Arbeit, Ausbildungsgang Sozialarbeit, 2008
sj-pdf-1-imr-10.1177_03000605211047277 - Supplemental material for Bloodstream infection caused by Bacteroides caccae in a patient with renal hypertension: a case report
Creators: name: Yang, Yang
name: Zhang, Qingfang
name: Hu, Haitao
name: Zhang, Wenyun
name: Lu, Taohong
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Health and Community Services
subject: Cardiology
subject: Dentistry not elsewhere classified
subject: Emergency Medicine
subject: Endocrinology
subject: Geriatrics and Gerontology
subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Nursing not elsewhere classified
subject: Nutrition and Dietetics not elsewhere classified
subject: Oncology and Carcinogenesis not elsewhere classified
subject: Orthopaedics
subject: Sports Medicine
subject: Otorhinolaryngology
subject: Aged Health Care
subject: Paediatrics
subject: Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: Psychology not elsewhere classified
subject: Psychiatry (incl. Psychotherapy)
subject: Public Health and Health Services not elsewhere classified
subject: Respiratory Diseases
subject: Sociological Methodology and Research Methods
subject: Surgery

description: Supplemental material, sj-pdf-1-imr-10.1177_03000605211047277 for Bloodstream infection caused by Bacteroides caccae in a patient with renal hypertension: a case report by Yang Yang, Qingfang Zhang, Haitao Hu, Wenyun Zhang and Taohong Lu in Journal of International Medical Research
THE INFLUENCE OF RELIGIOUS BELIEFS ON CONSUMER BEHAVIOR: EXAMINING REACTIONS TO CONTROVERSIAL PRODUCTS AND OFFENSIVE ADVERTISING APPEALS
Creators: name: Ahmed Ali, Khan
name: Fatima Zahra, Ahmed
Publisher: name: CARSON JOURNAL
Year: 2024
Subjects: Religiosity, Consumer Behavior, Controversial Products, Advertising Appeals, Marketing Strategies.

description: Religiosity plays a pivotal role in shaping individuals' values, beliefs, and practices, permeating into various aspects of daily life. In the realm of consumer behavior, religiosity serves as a fascinating construct that can significantly influence consumer choices and reactions. This paper endeavors to delve into the intricate relationship between religiosity and its impact on the perception of controversial products and the offensive nature of advertising appeals. Understanding how religiosity interplays with consumer behavior is essential in today's diverse marketplace, where consumers hail from a multitude of religious backgrounds and worldviews. To shed light on this phenomenon, this research commences with an exploration of the existing literature concerning the role of religion in shaping consumer behavior. By examining previous studies and theories, we aim to provide a comprehensive foundation for our investigation. The methodology section elucidates the rigorous data collection procedures and the specific measures adopted to scrutinize the multifaceted aspects of religiosity and its implications on consumer reactions. Our research adopts a holistic approach, encompassing both qualitative and quantitative data collection methods, in order to obtain a nuanced understanding of the subject matter. Subsequently, the paper presents the empirical results derived from the comprehensive analysis of collected data. These results unveil the intricate dynamics between religiosity, controversial products, and offensive advertising appeals. We provide insights into how varying degrees of religiosity influence consumers' perceptions, attitudes, and behaviors in response to such marketing strategies. In closing, the paper reflects on the limitations inherent in this study and outlines avenues for future research in this domain. The complexities of religiosity and its implications on consumer behavior warrant continued exploration, including investigating the moderating factors and potential cultural nuances that may influence these relationships.
A Theory for the Proton and the Solar System with a Characteristic Time of One Second
Creators: name: Beardsley, Ian
Publisher: name: Zenodo
Year: 2025

description: I came up with a theory that solves the Earth/Moon/Sun system in terms of the quantum mechanics wave equation. Interesting the solution had a characteristic time of 1 second, which lead to archaeological consideration because the second came to us from the ancient Sumerians base 60 counting. It was shown such counting can account for the second as a natural constant. Further I found this characteristic time was in a physics description of the proton, linking the microcosmos to the macrocosmos. This was in my paper “The Second As A Universal Characteristic Time”. I presented it to Deep Seek to do an AI analysis of the paper. One thing it said is that I should derive my equation for the radius of a proton from first principles. I told it I had already done that in another paper (it was titled: “The Search For The Galactic Codex”). I provided to Deep Seek how I did it, and it thought it was elegant and brought together quantum mechanics and relativity. In part one of this paper I will present this discussion I had with Deep Seek, and then, in part two I will provide the paper that goes into a short presentation of the whole theory, which also includes discussing how the Big Bang theory computes the setting of the number of protons in the universe at t=1 one second  after the Big Bang. In part three I will apply our theory to Jupiter and Saturn since they are the largest and most massive planet’s in the solar system carrying the majority of their mass in its formation. In part four I will apply our theory in general to other star systems. This has applications in exobiology because it should be able to be used to help determine what kinds of stars are optimal for life, and what kind of life might emerge around different kinds of stars, as well as what to expect from a star system that is optimally habitable. Included, we find our characteristic time might be at the crux of biological systems.
Additional file 1 of Mortality rates in Norwegian HEMS—a retrospective analysis from Central Norway
Creators: name: Wekre, Stian Lande
name: Uleberg, Oddvar
name: Næss, Lars Eide
name: Haugland, Helge
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Science Policy

description: Supplementary Material 1
sj-pdf-2-imr-10.1177_03000605211047277 - Supplemental material for Bloodstream infection caused by Bacteroides caccae in a patient with renal hypertension: a case report
Creators: name: Yang, Yang
name: Zhang, Qingfang
name: Hu, Haitao
name: Zhang, Wenyun
name: Lu, Taohong
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Health and Community Services
subject: Cardiology
subject: Dentistry not elsewhere classified
subject: Emergency Medicine
subject: Endocrinology
subject: Geriatrics and Gerontology
subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Nursing not elsewhere classified
subject: Nutrition and Dietetics not elsewhere classified
subject: Oncology and Carcinogenesis not elsewhere classified
subject: Orthopaedics
subject: Sports Medicine
subject: Otorhinolaryngology
subject: Aged Health Care
subject: Paediatrics
subject: Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: Psychology not elsewhere classified
subject: Psychiatry (incl. Psychotherapy)
subject: Public Health and Health Services not elsewhere classified
subject: Respiratory Diseases
subject: Sociological Methodology and Research Methods
subject: Surgery

description: Supplemental material, sj-pdf-2-imr-10.1177_03000605211047277 for Bloodstream infection caused by Bacteroides caccae in a patient with renal hypertension: a case report by Yang Yang, Qingfang Zhang, Haitao Hu, Wenyun Zhang and Taohong Lu in Journal of International Medical Research
sj-docx-2-hss-10.1177_15563316211051295 – Supplemental material for Return to Sport and Work Following Distal Femoral Varus Osteotomy: A Systematic Review
Creators: name: Abdel Khalik, Hassaan
name: Lameire, Darius L.
name: Rubinger, Luc
name: Ekhtiari, Seper
name: Khanna, Vickas
name: Ayeni, Olufemi R.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110323 Surgery
subject: FOS: Clinical medicine

description: Supplemental material, sj-docx-2-hss-10.1177_15563316211051295 for Return to Sport and Work Following Distal Femoral Varus Osteotomy: A Systematic Review by Hassaan Abdel Khalik, Darius L. Lameire, Luc Rubinger, Seper Ekhtiari, Vickas Khanna and Olufemi R. Ayeni in HSS Journal®: The Musculoskeletal Journal of Hospital for Special Surgery
Difusión Y Visibilidad De Publicaciones Científicas En Internet
Creators: name: García-Peñalvo, F. J.
Publisher: name: Zenodo
Year: 2018
Subjects: Diseminación científica; Divulgación científica; Revisión científica; Identidad digital del investigador; Ciencia abierta; Conocimiento abierto

description: El curso “Difusión y visibilidad de publicaciones científicas en Internet” fue impartido el día 24 de mayo de 2018 en el Instituto Universitario de Ciencias de la Educación (IUCE) dentro del Plan de Formación Docente 2018 de la Universidad de Salamanca.

Los objetivos de este curso son:

	Conocer distintas herramientas y redes sociales para promocionar las publicaciones científicas en Internet.
	Adquirir conocimientos básicos sobre marca personal investigadora en la red.
	Gestionar una red de contactos profesionales para promover la producción científica.

Los contenidos del curso son:

	La importancia de la diseminación y divulgación científica
	Ciencia abierta
	Identidad digital del investigador
	Reputación científica e índices de impacto
	El ecosistema de información científica

		ORCID
		ResearcherID
		Scopus Author ID
		Dimensions
		Google Scholar
		ResearchGate
		Academia
		Kudos
		Mendeley
		Redalyc
		Publons

	Crear la identidad digital del investigador en 8 pasos
	Conclusiones
sj-pdf-1-eex-10.1177_2515127420951956 - Supplemental material for An Examination of the Effect of New Venture Ideation Exercises on Entrepreneurial Intentions
Creators: name: Mathews, Robert D.
name: Wessel, Roger
name: Goldsby, Michael
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business

description: Supplemental material, sj-pdf-1-eex-10.1177_2515127420951956 for An Examination of the Effect of New Venture Ideation Exercises on Entrepreneurial Intentions by Robert D. Mathews, Roger Wessel and Michael Goldsby in Entrepreneurship Education and Pedagogy
Extending Explicitness And Expert Blind Spots  To The Psychology Of Novices
Creators: name: Wickes, Elizabeth
Publisher: name: Zenodo
Year: 2018
Subjects: teaching
software carpentry
data carpentry
expert blind spots
CarpentryCon

description: Poster for the 2018 CarpentryCon.

How much is too much? Instructors often invite students to reach out if: “you’re stuck”, “you aren’t sure”, “need help”, etc. But what if you are a novice and everything feels confusing and you’re never sure? I argue that these phrases are another aspect of the expert blind spot and can produce feeling of being hazed and spending time on homework that exceeds the intended workload. The experience of receiving help gives the experienced markers of when we aren’t making progress, which novices have not yet built up. This poster will highlight my instructional efforts to operationally define being “stuck”. Participants will also be invited to share their own anecdotes about what it feels like to be stuck on the poster as an interactive element.
description: {"references": ["Wickes, Elizabeth. (2018, May). Hard Shouldn't be Hardship: Supporting Absolute Novices to Python. Talk presented at the 2018 Python Education Summit. http://doi.org/10.5281/zenodo.1244334"]}
Additional file 1 of Assessing organizational readiness for the Clean Cuts and Sharp Minds Collective: a barbershop health promotion network
Creators: name: Wippold, Guillermo M.
name: Crichlow, Zion R.
name: Garcia, Kaylyn A.
name: Domlyn, Ariel
name: Sanchez, Shane
name: Frank, Lucina
name: Mote, Thrisha
name: Frary, Sarah Grace
name: Woods, Terry
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Hematology

description: Supplementary Material 1.
Investigation of the interaction between S-isoalkyl derivatives of the thiosalicylic acid and human serum albumin
Creators: name: Vesović, Marina
name: Jelić, Ratomir
name: Nikolić, Miloš
name: Nedeljković, Nikola
name: Živanović, Ana
name: Bukonjić, Andriana
name: Mrkalić, Emina
name: Radić, Gordana
name: Ratković, Zoran
name: Kljun, Jakob
name: Tomović, Dušan
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Hematology

description: S-isoalkyl derivatives of thiosalicylic acid (isopropyl-(L1), isobutyl-(L2) and isoamyl-(L3)) were selected in order to investigate the binding interaction with the human serum albumin (HSA) using different spectroscopic methods and molecular docking simulation. Association constants and number of binding sites were used to analyze the quenching mechanism. The experimental results showed that the fluorescence quenching of HSA by L1, L2 and L3 occurs because of static quenching and that binding processes were spontaneous, with the leading forces in bonding by hydrogen bonding, hydrophobic interactions, and electrostatic interactions. Fluorescence spectroscopy, UV-Vis spectroscopy and synchronous fluorescence spectroscopy showed that ligands (L1, L2 and L3) can bind to HSA and that the binding of ligands induced some microenvironmental and conformational changes in HSA. The calculated distance between the donor and the acceptor according to fiFörster’s theory confirms the energy transfer efficiency between the acceptor and HSA. Results of site marker competitive experiments showed that the tested compounds bind to HSA in domain IIA (Site I). Molecular dynamics and docking calculations demonstrated that L3 binds to the Sudlow site I of HSA with lower values of binding energies compared to L1 and L2, indicating the formation of the most stable ligand-HSA complex. Understanding the binding mechanisms of S-isoalkyl derivatives of the thiosalicylic acid to HSA may provide valuable data for the future studies of their biological activity and application as potential antitumor drugs.
Discovery of hematopoietic progenitor kinase 1 inhibitors using machine learning-based screening and free energy perturbation
Creators: name: Feng, Dazhi
name: Liu, Bo
name: Chen, Zhiwei
name: Xu, Jinyi
name: Geng, Meiyu
name: Duan, Wenhu
name: Ai, Jing
name: Zhang, Hefeng
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Hematopoietic progenitor kinase 1 (HPK1) is a key negative regulator of T-cell receptor (TCR) signaling and a promising target for cancer immunotherapy. The development of novel HPK1 inhibitors is challenging yet promising. In this study, we used a combination of machine learning (ML)-based virtual screening and free energy perturbation (FEP) calculations to identify novel HPK1 inhibitors. ML-based screening yielded 10 potent HPK1 inhibitors (IC50 < 1 μM). The FEP-guided modification of the in-house false-positive hit, DW21302, revealed that a single key atom change could trigger activity cliffs. The resulting DW21302-A was a potent HPK1 inhibitor (IC50 = 2.1 nM) and potently inhibited cellular HPK1 signaling and enhanced T-cell function. Molecular dynamics (MD) simulations and ADME predictions confirmed DW21302-A as candidate compound. This study provides new strategies and chemical scaffolds for HPK1 inhibitor development.
sj-docx-1-njn-10.1177_20571585211050331 - Supplemental material for Becoming a global nurse: A thematic and interpretive analysis of bachelor's theses at the Swedish Red Cross University College
Creators: name: Paillard Borg, Stéphanie
name: Kraft, Mia
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111099 Nursing not elsewhere classified
subject: 111799 Public Health and Health Services not elsewhere classified

description: Supplemental material, sj-docx-1-njn-10.1177_20571585211050331 for Becoming a global nurse: A thematic and interpretive analysis of bachelor's theses at the Swedish Red Cross University College by Stéphanie Paillard Borg and Mia Kraft in Nordic Journal of Nursing Research
sj-docx-1-jbc-110.1177_08839115211053925 – Supplemental material for Development of poly(ethyleneimine) grafted amphiphilic copolymers: Evaluation of their cytotoxicity and ability to complex DNA
Creators: name: Diaz, Ivonne L
name: Jérôme, Valérie
name: Freitag, Ruth
name: Perez, León D
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, sj-docx-1-jbc-110.1177_08839115211053925 for Development of poly(ethyleneimine) grafted amphiphilic copolymers: Evaluation of their cytotoxicity and ability to complex DNA by Ivonne L Diaz, Valérie Jérôme, Ruth Freitag and León D Perez in Journal of Bioactive and Compatible Polymers
IMPORTANCE OF INDICATORS OF NITROXIDERGIC SYSTEM IN IMPROVING THE TREATMENT OF ACUTE AND CHRONIC PURULENT SINUSITIS
Creators: name: Lutfullaev, Umrullo
name: Raximov, Farrux
name: Buriyev, Shamsiddin
name: Abdumannobov, Jaloliddin
name: Mardonov, Xoshim
Publisher: name: Zenodo
Year: 2024

description: In this article, an understanding of sinusitis, a topic relevant in today's medicine, is given, and detailed information is also given about their treatment methods. In addition, examples of new treatment measures are provided.
sj-docx-1-psx-10.1177_00323217211051191 – Supplemental material for Boris Johnson to the Rescue? How the Conservatives Won the Radical-Right Vote in the 2019 General Election
Creators: name: Evans, Geoffrey
name: de Geus, Roosmarijn
name: Green, Jane
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160607 International Relations
subject: FOS: Political science

description: Supplemental material, sj-docx-1-psx-10.1177_00323217211051191 for Boris Johnson to the Rescue? How the Conservatives Won the Radical-Right Vote in the 2019 General Election by Geoffrey Evans, Roosmarijn de Geus and Jane Green in Political Studies
sj-pdf-1-wcx-10.1177_07410883211052104 – Supplemental material for A Product- and Process-Oriented Tagset for Revisions in Writing
Creators: name: Conijn, Rianne
name: Speltz, Emily Dux
name: Zaanen, Menno van
name: Waes, Luuk Van
name: Chukharev-Hudilainen, Evgeny
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications

description: Supplemental material, sj-pdf-1-wcx-10.1177_07410883211052104 for A Product- and Process-Oriented Tagset for Revisions in Writing by Rianne Conijn, Emily Dux Speltz, Menno van Zaanen, Luuk Van Waes and Evgeny Chukharev-Hudilainen in Written Communication
sj-pdf-1-ccx-10.1177_10732748211051536 – Supplemental Material for Epidemiological Characteristics of Pancreatic Cancer in China From 1990 to 2019
Creators: name: Zhu, Bo
name: Wu, Xiaomei
name: Guo, Tianyu
name: Guan, Ning
name: Liu, Yefu
Publisher: name: SAGE Journals
Year: 2021
Subjects: Oncology and Carcinogenesis not elsewhere classified

description: Supplemental Material, sj-pdf-1-ccx-10.1177_10732748211051536 for Epidemiological Characteristics of Pancreatic Cancer in China From 1990 to 2019 by Bo Zhu, Xiaomei Wu, Tianyu Guo, Ning Guan and Yefu Liu in Cancer Control
Factors Influencing Repurchase Intentions in Inter-Provincial Bus Services: A Case Study of Transport Co., Ltd. (Bor Kor Sor) on Northern and Northeastern Routes
Creators: name: Methapat Jaovisidha
Publisher: name: University of the Thai Chamber of Commerce
Year: 2024
Subjects: Service Repurchase
Service Quality
Safety
Price Fairness
Technology Adoption

description: Journal of Family Business and Management Studies, 16, 2, 23-38