cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Development and characterization of water-soluble, photo-luminescent gold nanoparticles for bio-imaging
Creators: name: Lee, Chang-won
Publisher: name: University of Utah
Year: 2012
Subjects: Bioimaging
Gold nanoparticle
PH sensor

description: In this dissertation, we explored the synthesis of water-soluble and photoluminescence behavior near infrared emitting (610 nm) gold nanoparticles terminated by mercaptoalkanoic acid and possessing UV range (200~350 nm) excitation. Different effects were monitored as a function of reaction condition including different gold and ligand concentrations, types of ligands, solvents and pH. It is understood that Gold-thiol complexes were formed and developed into nanoparticle-supported complexes. Analyses of the excitation spectra suggests the origin of the photoluminescence to be transitions from the triplet energy state of LMMCT with the electrons transferred from excited orbitals of Au/Au(I) sites of the gold surface. It is also the reason for the enhanced photostability compared with those produced as free molecules via other synthesis methods. The pH dependency of the emission intensity and excitation spectra alteration of the gold nanoparticles was also explored. The emission intensity of the gold nanoparticle showed linear dependency on the pH change in the weak acidic to basic region above the pH 6 with a small peak appearance at pH 4. This trend was accompanied by a distinctive excitation peak wavelength change from 280-290 nm to 250-260 nm at pH 6.. A brush configuration change of the surface ligands was proposed to explain the pH dependency. In the charged and extended form of the carboxylic acid ligands, the accessibility of water to the gold nanoparticles surface is greater than in the uncharged collapsed form. Thus, in the collapsed form, the local hydrophobicity at the gold surface is higher and theCT excitation spectrum shifts to the blue. Its biocompatibility, as suggested by the cytotoxicity test and reactive oxygen species (ROS) generation test, provides broader opportunities for this product to be utilized in biological systems.
In vitro–ex vivo correlations between a cell-laden hydrogel and mucosal tissue for screening composite delivery systems
Creators: name: Blakney, Anna K.
name: Little, Adam B.
name: Jiang, Yonghou
name: Woodrow, Kim A.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Composite delivery systems where drugs are electrospun in different layers and vary the drug stacking-order are posited to affect bioavailability. We evaluated how the formulation characteristics of both burst- and sustained-release electrospun fibers containing three physicochemically diverse drugs: dapivirine (DPV), maraviroc (MVC) and tenofovir (TFV) affect in vitro and ex vivo release. We developed a poly(hydroxyethyl methacrylate) (pHEMA) hydrogel release platform for the rapid, inexpensive in vitro evaluation of burst- and sustained-release topical or dermal drug delivery systems with varying microarchitecture. We investigated properties of the hydrogel that could recapitulate ex vivo release into nonhuman primate vaginal tissue. Using a dimethyl sulfoxide extraction protocol and high-performance liquid chromatography analysis, we achieved >93% recovery from the hydrogels and >88% recovery from tissue explants for all three drugs. We found that DPV loading, but not stacking order (layers of fiber containing a single drug) or microarchitecture (layers with isolated drug compared to all drugs in the same layer) impacted the burst release in vitro and ex vivo. Our burst-release formulations showed a correlation for DPV accumulation between the hydrogel and tissue (R2= 0.80), but the correlation was not significant for MVC or TFV. For the sustained-release formulations, the PLGA/PCL content did not affect TFV release in vitro or ex vivo. Incorporation of cells into the hydrogel matrix improved the correlation between hydrogel and tissue explant release for TFV. We expect that this hydrogel-tissue mimic may be a promising preclinical model to evaluate topical or transdermal drug delivery systems with complex microarchitectures.
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 07.12.1970, erstellt von Peter Rovithis, Eugenides Planetarium in Athen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Eugenides Planetarium in Athen der Eugenides Stiftung, Griechenland. Später wurden ergänzende Angaben aufgrund weiterer Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Instrument: Zeiss (Coudé-Refraktor 150mm, projiziertes Sonnenbild D = 25cm)
Performance of reinforced concrete panels during blast loading
Creators: name: Garfield, Timothy T.
Publisher: name: University of Utah
Year: 2012
Subjects: Explosion
Fiber concrete
Glass fiber reinforced polymer
Reinforced concrete

description: The structural integrity of reinforced concrete structures subjected to blast loading is important for critical facilities. This thesis presents experimental data generated that evaluate the performance of reinforced concrete wall panels with a wide range of construction details under blast loading. The test specimens were 4 ft. square wall panels constructed using Normal Weight Concrete (NWC) or Fiber Reinforced Concrete (FRC). FRC consists of macrosynthetic fibers dispersed in NWC. Five types of panels were tested: NWC panels with steel bar reinforcement (Type A); FRC panels without additional reinforcement (Type B); FRC panels with steel bar reinforcement (Type C); NWC panels with glass fiber reinforced polymer (GFRP) bar reinforcement (Type D); and NWC panels reinforced with steel bar reinforcement and external bidirectional GFRP overlays on both faces (Type E). Three additional Type D panels were used as control specimens (CON). Each panel type was constructed with three thicknesses: 6 in., 10 in., and 14 in. The panels were instrumented with strain gauges, and accelerometers; in addition, pressure sensors and high speed video were used during the blast events.  Panel types C and E consistently were visually damaged the least by the explosion; the damage that was visually inspected was the crack width, loss of concrete by fragmentation, and deflection of the panel. Based on these criteria panel types C and E were the best panels at resisting the blast loading. The 6 in. and 10 in. thick type B panels consistently broke into two pieces causing complete structural failure of the panel; panel type B was the worst performing panel because of the complete structural failure. The spacing of the reinforcement proves to be very important. The closer the spacing the better the panel performed at resisting damage caused by the blast. The FRC concrete performed better than the NWC, and the thickness of the panels proved to be equally important at resisting the shearing forces caused by the blast.
title: Materials in nuclear energy applications
Creators: name: McKinney, Logan
Publisher: name: URMSE
Year: 2020

description: Nuclear energy is growing in importance as a form of clean energy, and many of the limiting factors for its development are materials based. There is a need for materials that can make reactor components that are resilient to extreme environments. This review article highlights multiple studies regarding the state of materials development for nuclear energy. Among the topics discussed are tritium production and how it causes failure, methods of simulating component damage, thermomechanical properties of multi-principal element alloys, and corrosion resistance of nickel alloys. Simulations involving the conditions found in fast and fusion reactors show that fast neutrons cause much shallower and more uniform damage compared to the heavier ions found in fusion reactors. Another important finding is that nickel-based alloys have much higher corrosion resistance than steels, and higher nickel content in these alloys translates to higher resistance.
Sonnenfleckenzeichnung Nr. 23380.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 22.06.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
title: Advances in ion injection in organic electrochemical transistors
Creators: name: Mee, Erin
Publisher: name: URMSE
Year: 2020

description: Organic electrochemical transistors (OECTs) utilize conjugated polymer’s ability to conduct both ions and electronic holes to create devices that can interface with biology along with being used in neuromorphic and memory applications. Improving OECT design means better understanding the physics of ion injection and the effects of hydration on different conjugated polymers. Recent studies have found that OECT performance benefits from hydrophilic side chains on conjugated polymers. Performance has also been found to decrease in highly crystalline polymers. Additionally, ionic liquids have been utilized either in doping a conjugated polymer or in creating an ion exchange gel interface to improve performance. Finally, certain polymers exhibit a phase change upon ion injection resulting in a sharp ion front.
Sonnenfleckenzeichnung Nr. 23365.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 07.06.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Synthesis and reactivities of related halo- and aminohalophosphine species
Creators: name: Snow, Sarah Severson
Publisher: name: University of Utah
Year: 2015
Subjects: Halophosphine
Chemistry
Synthesis
Reactivity

description: The chemistry of a r e la t iv e ly simple halophosphine, difluorophosphine, has created a surpr ising amount of controversy and in te re s t in the l i te ra tu re for the la s t 20 years. The re la t iv e base strength of PF2 H vs PF3 , PH3 and related compounds has been questi oned. This work reviews the PF2H l i te ra tu re and examines the unusual or unexplained factors involved, and then delves into the problem via new experimental pathways. An e f fe c t ive route to NiL4 complexes (L = PC 13 , PF3 , PF2 C1, Me2 NPF2 , PF2 H) has been developed to f a c i l i ta t e the study of the Ni-P bond strength in ^ ^ 3 )4 , Ni(PF2 H) 4 and N i (P H 3 ) 4 and related species. Selected ligand exchange reactions are described. Phosphine substituted nickel carbonyl compounds were also of in te re s t . The f i r s t procedure for the qu ant i ta t ive preparation of (CO)3 NiL (L = Me2 NPF2, (Me2 N)2PF and CH3 NCH2 CH2 (CH3 )NPF) is presented. Synthetic routes to two new PF2H complexes, (CO)3 Ni(PF2 H) and (C0)2 N i (PF2 H) 2 are also developed. Both PF2H complexes are f u l ly characterized, and th e i r inf rared data are used to help cor relate the r e la t iv e sigma base/pi acid character of PF2 H. Ligand exchange reactions involving the disubst ituted species are described. PF2 H appears to behave normally with respect to nickel; the re la t iv e sigma base/pi acid character of PF2H is intermediate between those of PF3 and PH3 . Our in te re s t in the chemistry of PF2 H stimulated an in te re s t in P-H compounds in general and (R2 N)2PH type compounds in p a r t ic u la r . Four new secondary aminophosphines (Me2 N)2 PH, CH3 NCH2 CH2 (CH37 n])H, (C0)3 Ni[(Me2 N)2 PH] and (CO)3 Ni[CH3 NCH2 CH2 (CH3 )NPH] have been synthesized and characterized. A new nickel phosphorus cation, (CO) 3 Ni[CH3 NCH2 CH2 (CH3 )NPD+, has also been prepared. New routes to PF2H were also sought. PF2H could not be prepared via the reduction of PF2 C1 by L-Selectride, N-Selectride, KSe le c t r id e , B2 H6, LiAl[0C(CH3)3]3H or [(CH3 )2 CHCH2 ]2 A1H. (Me2 N)2PH and (C0)3 N i[(Me2 N)2 PH] have been investigated as possible precursors for PF2H species. I n i t i a l re s u l ts from the reactions of these species with HF indicate that PF2H and (CO)3 Ni(PF2 H) can be prepared. These reactions are described.
Sonnenfleckenzeichnung Nr. 23390.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 02.07.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Automation of performance measures
Creators: name: Orton, Janette Anderson
Publisher: name: University of Utah
Year: 2012
Subjects: Health Care Quality, Access, and Evaluation

description: Performance of generic indicators is measurements that are designed to provide insight into the processes of a hospital or medical staff.   Since their beginning in the 1980's, generic indicators have traditionally provided clinical and satisfaction data. A balanced report including financial, utilization and satisfaction indicators provides a comprehensive high-level picture for the administration and medical staff leadership.  This information lends itself to a consistent, automated process to compare information across hospitals and medical staff departments.  This thesis describes the efforts of the Automation Team of the Quality Resource of the Urban Central Region Intermountain Health Care, Inc. to (1)  standardize corporately defined genetic indicators definition, (2) publish the indicator data quarterly for governing board, medical executive committee and medial staff departments through an automated application, (3) provide a method for statistical analysis for each indicator and (4) evaluate the process of Performance Measures Report (PMR) production though a study of content and efficiency of report production.  Standardized definitions and data sources were developed and provided on IHC's Intranet.  Quarterly reports were produced using the Intranet.  Analysis of the reports did not demonstrate a significant improvement in the consistency of required elements on the PMR.  The percentage of indicator with special cause variation did not change, but the automated application provided a method to identify indicators with this variation prior to the presentation of the reports to the medical staff department.  The efficiency of report production was statistically improved (10.51 hours vs. 7.01 hours, p = .0004).  A decrease in independent data sources used to produce the report was also noted (7.05 vs 5.36 sources p = .0005).  The process of automation provide vale to IHC through providing consistent, reproducible definition, standardized data sources, identification of report standards, and a consistent method for statistical analysis.
Sonnenfleckenzeichnung Nr. 23344.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 15.05.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
title: Textile recycling via ionic liquids
Creators: name: Robinson, Emily Grace
Publisher: name: URMSE
Year: 2020

description: Textile waste is a global problem, as it comprises a significant portion of landfill mass. Textile demand is increasing, which places demands on agriculture to produce more cotton. Industry standards of spinning and dyeing cotton fibers is hazardous and consumes large amounts of energy. The viscose method of wet spinning is the most common industry method, and uses large amounts of water, time and energy. Ionic liquids (ILs) have been shown to dissolve organic matter such as cellulose fibers and have shown promise in separating waste polymer-cellulose textile blends. When the cellulose concentration is high enough, the IL-cellulose solution can be wet spun, producing recycled fibers. The remaining polymer fibers can also be respun and possess characteristics competitive to virgin polyester fibers. The process has been shown to preserve dyes, if desired, or remove the original coloring and produce neutral fibers, relieving industry strain in the dyeing process and saving time, water, and energy.
Cis and trans-acting factors that regulate hepatitis A virus translation
Creators: name: Glass, Michael John
Publisher: name: University of Utah
Year: 2012
Subjects: Picornaviruses
Cap-independent

description: Picornaviruses have been shown to translate their genomes by binding ribosomes to internal sequences withing the 5'-noncoding region (5'NCR) of the viral RNA genome.  The internal ribosome binding sites (RES) has been mapped to the 5'NCR of all picornaviruses studies so far.  The experiments presented in this dissertation have been designed to identify the cis- and trans- acting factors that effect hepatitis A virus (HAV) translation.  Studies provided in chapter II describe the minimal sequence required for cap-independent translation of HAV monocistronic RNA in vitro.  The region between nucleotides 347 and 734 is required for translation in this system.  By utilizing bicistronic RNAs containing the HAV 5'NCR, Chapter II further defines those sequences by determining that HAV also translated by internal initiation and contains an IRES element that exists between nucleotides 45 and 734.  Comparative analysis using capped and uncapped bi- and monocistronic RNAs showed that RNA synthesized with 5'-terminal methylated cap group allows for more efficient translation that RNA containing only the HAV IRES.  Studies in Chapter IV describe the existence of a trans-acting activity fournd in liver cells that stimulates HAV translation in vitro.  This activity appears to be specific to HAV RNA and could not be found in other cell of tissue culture origin or kidney, heart and brain extracts derived from the mouse.  In combination, the studies presented in this dissertation may help elucidate the possible causes for the slow-growth and pathogenicity exhibited by HAV.
Sonnenfleckenzeichnung Nr. 23334.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 01.05.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Role of the C62;5 and Dnak heat shock proteins in the response to nutritional deprivation and characterization of the C62;5 protein
Creators: name: Spence, Jean
Publisher: name: University of Utah
Year: 2012
Subjects: Yeast
Mice

description: Several eukaryotic organisms have a conserved pattern of induction of the heat shock proteins or their cognates during development that is uncoupled from the heat shock response. Two of these proteins, hsp84 and hsp70, are conserved throughout evolution and are homologous to HtpG and DnaK respectively of Escherichia coli. As the most primitive form of development is sporulation, a response to nutritional deprivation, we tested the ability of E. coli cells with mutations in dnaK or htpG to respond to starvation for carbon, nitrogen or phosphate. The htpG mutants were found to respond to starvation like their wild type parents. DnaK103 mutants, however, were highly sensitive to starvation for carbon, and to a lesser extent, to starvation for nitrogen and phosphate. Analysis of proteins induced under starvation conditions on two-dimensional gels showed that the dnaK103 mutant is defective for the synthesis of some proteins under catabolic control and some starvation induced proteins which are synthesized at high levels during the stationary phase and under all starvation conditions. Furthermore, the dnaK103 mutant synthesized a unique set of proteins during starvation. Although the synthesis of some carbon starvation proteins was altered by the dnaK103 mutation, the synthesis of proteins specifically induced by nitrogen starvation was unaffected. Similarly, the dnaK103 mutant was able to utilize glutamine or arginine as sources of nitrogen at a rate approximate to the wild type parent, but it inefficiently utilized glycerol or maltose as carbon sources. Several differences in the protein pattern of the dnaK103 mutant and wild type were observed after phosphate starvation. In addition, the highly conserved Escherichia coli protein, HtpG, was overproduced and purified by column chromatography on DEAE-52 cellulose, hydroxyapatite, and Sephacryl S-200 columns. Immunoprecipitation of labeled cells with antisera specific for HtpG demonstrated that this protein is a phosphoprotein. The native molecular weight, determined by gel filtration and sedimentation analysis, was twice the molecular weight as determined by DNA sequence analysis. Thus, like its eukaryotic homologue,hsp84, HtpG is a dimer and a phosphoprotein.
title: Manufacturing, structure, and properties of crosslinked polyethylene induced by peroxides
Creators: name: Renjie, Song
Publisher: name: URMSE
Year: 2020

description: Crosslinking of polyethylene induced by peroxides can greatly improve some of its properties such as stability and impact strength. The underlying material science is well-known yet provides great potential for process optimization as well as product amelioration. In this review, the structure-processing-property relationship of crosslinked polyethylene is introduced with a focus on the chemical reaction mechanisms involved.
Sonnenfleckenzeichnung Nr. 23353.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 25.05.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Effective intraperitoneal gene transfection system using nanobubbles and ultrasound irradiation
Creators: name: Nishimura, Koyo
name: Fumoto, Shintaro
name: Fuchigami, Yuki
name: Hagimori, Masayori
name: Maruyama, Kazuo
name: Kawakami, Shigeru
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Plant Biology
subject: Computational Biology

description: In this study, we demonstrate the low toxicity and highly efficient and spatially improved transfection of plasmid DNA (pDNA) with liposomal nanobubbles (bubble liposomes [BLs]) using ultrasound (US) irradiation in mice. Naked pDNA with BLs was intraperitoneally injected, followed by US irradiation. The injection volume, the duration of US irradiation, and the dose of BLs were optimized. Both BLs and US irradiation were essential to achieve high transgene expression from naked pDNA. We observed transgene expression in the entire peritoneal tissues, including the peritoneal wall, liver, spleen, stomach and small and large intestines. The area of transfection could be controlled with focused US irradiation. There were few changes in the morphology of the peritoneum, the peritoneal function or serum alanine aminotransferase levels, suggesting the safety of BLs with US irradiation. Using a tissue-clearing method, the spatial distribution of transgene expression was evaluated. BLs with US irradiation delivered pDNA to the submesothelial layer in the peritoneal wall, whereas transgene expression was restricted to the surface layer in the liver and stomach. Therefore, BLs with US irradiation could be an effective and safe method of gene transfection to the peritoneum.
Nursing diagnosis of left ventricular failure in acute myocardial infarction
Creators: name: Miller, Alfred Bobby
Publisher: name: University of Utah
Year: 2012
Subjects: Pathophysiological
Hemodynamic

description: A new mode of therapy has recently been advocated for the treatment of left ventricular failure (LVF) due to acute myocardial infarction (AMI). This therapy involves the use of vasodilator drugs. Current literature places little emphasis on the clinical findings of the effects of vasodilators. This is especially true of nursing literature. Registered nurses (RN) in coronary care units (CCU) throughout the country are responsible for the monitoring and administration of vasodilator therapy. The majority of RNs use hemodynamic measurements as their only data to administer vasodilators. It is a well-known fact that electronic equipment utilized to obtain hemodynamic measurements can produce inaccurate data. Several medical studies exist which document the relationships between clinical findings and hemodynamic measurements during LVF due to AMI.  Providing adequate care requires the RN to acquire appropriate skills and be capable of correlating these skills with all available data. The investigator theorized that a properly prepared RN could assess, diagnose and place patients, with LVF due to AMI, into clinical and hemodynamic subsets for purposes of management.  A continuous measurement experimental design as described by Drew (1976) was utilized. The subject population consisted of 30 patients  with AMI. The investigator utilized multiple assessments on each subject while providing a continuous measurement of the subjects'clinical progress throughout medical therapy. The majority of subjects (23) did not require hemodynamic monitoring. Correlation of clinical and hemodynamic subsets for those subjects who were monitored is not consistent.   A significant percentage (26.6%,) of the subject population were less than 50 years of age. Therapeutic regimes could not be compared because of the physicians' reluctance to record appropriate data. Appropriately prepared RNs are capable of performing cardiovascular assessments while obtaining a sound clinical data base upon which to arrive at a nursing diagnosis. Utilizing the subset classification system, the RN could begin management of patients with LVF due to AMI on a regular basis. This may reduce the number of fatalities due to LVF.
Sonnenfleckenzeichnung Nr. 23475.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 02.10.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Polyunsaturated fatty acid-based targeted nanotherapeutics to enhance the therapeutic efficacy of docetaxel
Creators: name: Ramasamy, Thiruganesh
name: Sundaramoorthy, Pasupathi
name: Ruttala, Hima Bindu
name: Choi, Yongjoo
name: Shin, Woo Hyun
name: Jeong, Jee-Heon
name: Ku, Sae Kwang
name: Choi, Han-Gon
name: Kim, Hwan Mook
name: Yong, Chul Soon
name: Kim, Jong Oh
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Since breast cancer is one of the most lethal malignancies, targeted strategies are urgently needed. In this study, we report the enhanced therapeutic efficacy of docetaxel (DTX) when combined with polyunsaturated fatty acids (PUFA) for effective treatment of multi-resistant breast cancers. Folic acid (FA)-conjugated PUFA-based lipid nanoparticles (FA-PLN/DTX) was developed. The physicochemical properties, in vitro uptake, in vitro cytotoxicity, and in vivo anticancer activity of FA-PLN/DTX were evaluated. FA-PLN/DTX could efficiently target and treat human breast tumor xenografts in vivo. They showed high payload carrying capacity with controlled release characteristics and selective endocytic uptake in folate receptor-overexpressing MCF-7 and MDA-MB-231 cells. PUFA synergistically improved the anticancer efficacy of DTX in both tested cancer cell lines by inducing a G2/M phase arrest and cell apoptosis. Combination of PUFA and DTX remarkably downregulated the expression levels of pro-apoptotic and anti-apoptotic markers, and blocked the phosphorylation of AKT signaling pathways. Compared to DTX alone, FA-PLN/DTX showed superior antitumor efficacy, with no signs of toxic effects in cancer xenograft animal models. We propose that PUFA could improve the therapeutic efficacy of anticancer agents in cancer therapy. Further studies are necessary to fully understand these findings and achieve clinical translation.
Nanoemulsion-based delivery system for enhanced oral bioavailability and Caco-2 cell monolayers permeability of berberine hydrochloride
Creators: name: Li, Yong-Jiang
name: Hu, Xiong-Bin
name: Lu, Xiu-Ling
name: Liao, De-Hua
name: Tang, Tian-Tian
name: Wu, Jun-Yong
name: Xiang, Da-Xiong
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology

description: Berberine hydrochloride (BBH) has a variety of pharmacological activities such as antitumor, antimicrobial, anti-inflammation, and reduce irritable bowel syndrome. However, poor stability and low oral bioavailability limited its usage. Herein, an oil-in-water nanoemulsion system of BBH was developed to improve its stability and oral bioavailability. The pseudoternary phase diagrams were constructed for the determination of composition of various nanoemulsions. The nanoemulsions of BBH composed of Labrafil M 1944 CS (oil phase), RH-40 (surfactant), glycerin (co-surfactant), and water (aqueous phase). The O/W nanoemulsion of BBH showed a relative bioavailability of 440.40% compared with unencapsulated BBH and was stable in our 6-month stability study. Further, there was a significant increase in intestinal permeability of BBH as assessed by Caco-2 cell monolayers and a significant reduction in efflux of BBH by the multidrug efflux pump P-glycoprotein. This study confirmed that the nanoemulsion formulation could be used as an alternative oral formulation of BBH to improve its stability, oral bioavailability and permeability.
Development, verification, and validation of the responsive boundary model for pool fire simulations
Creators: name: Eldredge, Weston M.
Publisher: name: University of Utah
Year: 2012
Subjects: Boundary conditions
Combustion
Data consistency
Pool fires
Validation
Verification

description: The need to understand and predict the behavior of fires and explosions is important considering the amount of property damage and the loss of life that can result. In the case of transportation pool fires (fires resulting from liquid fuel spills), predictive science is an especially valuable tool considering that experiments with large pools fires are costly and often lead to damaged or destroyed instrumentation. In the development of fire codes as well as in other areas of computational science, the need for fidelity in computational results has become a prominent issue. The various sources of error in computation, such as discretization error, machine round-off error, iterative convergence error, programmer  error, and model error, must be accounted for and, if possible, quantified if computational results are to be considered legitimate.  The current study seeks to remedy an important source of error in pool fire simulations. The error stems from the application of a simplistic fuel inlet boundary condition. Traditionally this type of boundary condition assumes that the liquid pool vaporizes fuel to feed the flame at a constant rate. Additionally the vaporization rate is assumed to be uniform over the pool surface. In reality there is a complex feedback mechanism between the pool surface and the flame. Pool vaporization rate changes with time as the pool is heated, and thermal flux to the pool will be nonuniform over the surface. The responsive Boundary model utilizes energy and mass conservation principles to model the thermal behavior of  the fuel pool and to predict the vaporization rate given thermal input from the flame.  Verification tests such as the Method of Manufactured Solutions and grid convergence and validation methods such as model input sensitivity analysis and consistency analysis are applied to the Responsive Boundary model on its own and linked with the gas-phase fire code (ARCHES). The tests verify that the code solves the continuum model that is the basis of the boundary model with acceptable error. A region of consistency is also  found between the steady vaporization fluxes predicted from the model and experimental data for a small heptane pool fire. Consistency analysis is also applied to data obtained from ARCHES simulations of a small helium plume and data taken from holographic  interferometric images.
Compliant microjoint replacements
Creators: name: Ford, Kurtis Ross
Publisher: name: University of Utah
Year: 2012
Subjects: Micro compliant bistable mechanism
Micro-compliant linkage
Mircohinge
Out-of-plane spiral actuator
Remote actuation
Scanning electron microscope
Compliant microjoints

description: Contact surfaces in micromechanical pin joints, hinges, and sliders introduce stiction and friction that disrupt motion in micro-electromechanical systems (MEMS). This thesis presents compliant design alternatives that move both in-plane and out-of-plane without introducing contact interference. This document correlates experimental results from fabricated devices to numeric models developed to predict key mechanical responses. The microsystems include the following:  • A spiral cantilever spring (shaped like a watch spring) deflects out-of-plane 70% of its largest in-plane dimension. The deflection occurs because of force imparted by injected charge from a scanning electron microscope.  • Compliant beams in torsion enable motion that is similar to that of a bushing-style substrate or scissor hinge.  • A manual torsion load turns an elastic hoop inside-out as an example of a compliant bistable threshold hinge.  • A compliant linkage symmetrically translates in-plane rotary motion to radial motion, similar to a blade aperture mechanism in a camera.  These devices exemplify microsystems that avoid failure-inducing surface contact by exploiting an increase in component compliance that occurs as a result of lower bending and torsion stress response in beams with microscale cross-sections.
Assessing the effect of adverse hospital events on the cost of hospitalization and other patient outcomes
Creators: name: Classen, David Carey
Publisher: name: University of Utah
Year: 2012
Subjects: Utah
Economics

description: It is estimated that in 1992 the United States spent 14% of its gross domestic product on health care. This level of health care spending is the highest in the world and almost twice as high as any other country. It is expected that 20% of the gross domestic product of the United States will be spent on health care by the year 2000. This has raised considerable interest in methods for health care cost containment. Assessing cost outcomes of medical care is one method of measuring and comparing the costs of medical care. Hospitals account for the largest share of health care spending. Unfortunately methods for linking detailed cost outcomes with hospital care are primitive at best. This study develops a methodology to link adverse effects of clinical care in the hospital with detailed cost outcomes. This study focusses on three adverse events that are common in hospital patients and are associated with large resource use.  For this project a hospital information system known as HELP was used. This system is a comprehensive clinical information in operation at LDS Hospital where this study was performed. The HELP System is linked with an IBM Financial system. Patient hospitalizations are linked in both systems by a unique identifier, which allowed linking of clinical and financial information. The HELP system includes a variety of surveillance programs that detect various adverse events occurring in hospital patients including nosocomial surgical wound infections and urinary tract infections and adverse drug events. This study matched patients with each of these three adverse events to cohort patients base on sex, age, discharge diagnosis, severity of illness, and calendar year of discharge. Attributable differences in hospital length of stay and costs were compared using an attribution methodology.  Over the period January 1, 1990 to August 1, 1992, a total of 1,552 case patients with these adverse events were matched to 17,747 cohort patients without these events. The mean attributable difference in length of stay between cases and matched cohorts for nosocomial surgical wound infections was 5.34 days (p < .00001). The mean attributable difference in hospital costs between the nosocomial surgical wound infection patients and the matched patients was $4,935 (p < .00001). The mean attributable difference in length of stay between the cases and matched cohorts for UTIs was 3.84 days (p< .00001). The mean attributable difference in hospital costs between the urinary tract infection patients and the matched patients was $3,803 (p
Dynamic characteristics and seismic stability of expanded polystyrene geofoam embankments
Creators: name: Amini, Zahra A.
Publisher: name: University of Utah
Year: 2014
Subjects: Dynamic
Embankment
EPS
FLAC
Geofoam
Seismic

description: Expanded Polystyrene (EPS) geofoam has become a preferred material in various construction applications due to its light weight. Application of EPS accelerates the projects particularly on soft soils. The focus of this research is on the application of the EPS in embankments and its behavior mainly under harmonic vibration. The goal of this study was to investigate dynamic characteristics of freestanding vertical EPS geofoam embankment and address potential seismic issues that result from the distinguished dynamic behavior of such systems due to the layered and discrete block structure. A series of experimental studies on EPS 19 and a commercially available adhesive was conducted. Two-dimensional numerical analyses were performed to replicate the response of EPS geofoam embankment to horizontal and vertical harmonic motions. The results of the analyses have shown that for some acceleration amplitude levels interlayer sliding is expected to occur in EPS geofoam embankments almost immediately after the start of the base excitation; however, as a highly efficient energy dissipation mechanism sliding ceases rapidly. Shear keys and adhesive may be used to prevent interlayer sliding if they cover the proper extent of area of the embankment. EPS blocks placed in the corners of the embankment and at the edges of the segment prohibited from sliding may experience high stress concentrations. The embankment may show horizontal sway and rocking once sliding is prevented.
Why time away from practice improves performance: a test of three memory-based explanations
Creators: name: Sorensen, Linda Jean
Publisher: name: University of Utah
Year: 2014

description: Prior evidence from several research areas suggests that performance improvements can accrue during intervals that preclude further practice of a procedural skill; however, the mechanism underlying this improvement is unclear. In order to test competing explanations for such improvement, the author investigated the effects of varying the cognitive demands of a secondary task interpolated into a course of cognitive skill practice. The moderately complex skill task that was used presented electrical circuitry operations (logic gates) and their corresponding rules, which participants learned first through declarative instruction and thereafter through multiple blocks of procedural practice. The interpolated task was either a cognitively demanding working memory (WM) test or a noncognitively demanding period spent listening to binaural alpha-wave beats over headphones. Three theory-based explanations for skill improvement during the interpolated task, or gap facilitation, were tested: memory consolidation, release from proactive interference (PI), and mental rest. Each explanation makes unique predictions regarding parameters of a power function used to describe the trajectory of each participant's skill performance before and after the interpolated tasks. Evidence favored release from PI as being responsible for the observed gap facilitation effects. Findings are interpreted with respect to learning theory that predicts performance decline with time away from practice and in light of prior explanations of evidence to the contrary.