cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Association between Deepwater Horizon oil spill response and cleanup work experiences and lung function
Creators: name: Engel, L.S.
name: Lichtveld, M.Y.
name: Curry, M.D.
name: McGrath, J.A.
name: Kwok, R.K.
name: Gam, K.B.
name: Jackson, W.B.
name: Sandler, D.P.
name: Stewart, P.A.
name: Stenzel, M.R.
Publisher: name: Elsevier Ltd
Year: 2018

description: Introduction: Oil spill response and cleanup (OSRC) workers had potentially stressful experiences during mitigation efforts following the 2010 Deepwater Horizon disaster. Smelling chemicals; skin or clothing contact with oil; heat stress; handling oily plants/wildlife or dead animal recovery; and/or being out of regular work may have posed a risk to worker respiratory health through psychological stress mechanisms. Objective: To evaluate the association between six potentially stressful oil spill experiences and lung function among OSRC workers 1–3 years following the Deepwater Horizon disaster, while controlling for primary oil spill inhalation hazards and other potential confounders. Methods: Of 6811 GuLF STUDY participants who performed OSRC work and completed a quality spirometry test, 4806 provided information on all exposures and confounders. We carried out complete case analysis and used multiple imputation to assess risk among the larger sample. Potentially stressful work experiences were identified from an earlier study of these workers. The lung function parameters of interest include the forced expiratory volume in 1 s (FEV1, mL), the forced vital capacity (FVC, mL) and the ratio (FEV1/FVC, %). Results: On average, participants in the analytic sample completed spirometry tests 1.7 years after the spill. Among workers with at least 2 acceptable FEV1 and FVC curves, workers with jobs that involved oily plants/wildlife or dead animal recovery had lower values for FEV1 (Mean difference: −53 mL, 95% CI: −84, −22), FVC (Mean difference: −45 mL, 95% CI: −81, −9) and FEV1/FVC (Mean difference: −0.44%, 95% CI: −0.80, −0.07) compared to unexposed workers in analyses using multiple imputation. Conclusions: Workers involved in handling oily plants/wildlife or dead animal recovery had lower lung function than unexposed workers after accounting for other OSRC inhalation hazards.
title: Ανάπλαση νεοκλασικού διατηρητέου κτιρίου στον Πειραιά
title: Reconstruction of a neoclassical listed building in Piraeus
titleType: AlternativeTitle
Creators: name: Χρυσοφός, Γεώργιος
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2022
Subjects: Νεοκλασσικό
Πειραιάς
Διατηρητέο

description: Η πτυχιακή εργασία πραγματεύεται τον επανασχεδιασμό ενός διατηρητέου νεοκλασικού στον Πειραιά. Το εν λόγω διατηρητέο βρίσκεται στην οδό Φραγκιάδων 28 και Ευεργετών, στον Πειραιά και θα έχει τη χρήση σχολής κλασικού και σύγχρονου χορού. Κεντρική ιδέα της εργασίας, αποτελεί ο συνδυασμός της νεοκλασικής με την σύγχρονη αρχιτεκτονική. Αρχικά, πραγματοποιείται μια συνοπτική θεωρητική έρευνα στην ιστορία του Πειραιά, από τα προϊστορικά χρόνια μέχρι και σήμερα. Στη συνέχεια, γίνεται αναφορά στην ιστορία της νεοκλασικής αρχιτεκτονικής, και δίδονται απαντήσεις σε ερωτήματα όπως στο με ποιο τρόπο αυτή η αρχιτεκτονική εδραιώθηκε στην Ελλάδα και ποια είναι τα βασικά χαρακτηριστικά της. Παράλληλα, γίνεται λόγος για τη σύγχρονη αρχιτεκτονική, τα βασικά χαρακτηριστικά της, για ποιο λόγο έκανε την εμφάνιση της, και το πώς μπορεί να συνδυαστεί με την νεοκλασική αρχιτεκτονική, με τη χρήση παραδειγμάτων. Εν κατακλέιδι, διεξάγεται έρευνα πάνω στο αρχιτεκτονικό και σχεδιαστικό κομμάτι της σχολής χορού, σύμφωνα με τις ανάγκες της και τις λειτουργείες της, ενώ με την παρουσίαση κατόψεων, όψεων, τομών και φωτορεαλιστικών, θα προβάλετε η τελική πρόταση, στην οποία θα εντάσσεται εσωτερικά και η κεντρική ιδέα σχεδιασμού της.
DNA Methylation of a GC Repressor Element in the Smooth Muscle Myosin Heavy Chain Promoter Facilitates Binding of the Notch-Associated Transcription Factor, RBPJ/CSL1
Creators: name: Mack, C. P.
name: Rozenberg, J. M.
name: Musunuri, S.
name: Tesfu, D. B.
name: Taylor, J. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: OBJECTIVE: The goal of the present study was to identify novel mechanisms that regulate smooth muscle cell (SMC) differentiation marker gene expression.

APPROACH AND RESULTS: We demonstrate that the CArG-containing regions of many SMC-specific promoters are imbedded within CpG islands. A previously identified GC repressor element in the SM myosin heavy chain (MHC) promoter was highly methylated in cultured aortic SMC but not in the aorta, and this difference was inversely correlated with SM MHC expression. Using an affinity chromatography/mass spectroscopy-based approach, we identified the multifunctional Notch transcription factor, recombination signal binding protein for immunoglobulin κ J region (RBPJ), as a methylated GC repressor-binding protein. RBPJ protein levels and binding to the endogenous SM MHC GC repressor were enhanced by platelet-derived growth factor-BB treatment. A methylation mimetic mutation to the GC repressor that facilitated RBPJ binding inhibited SM MHC promoter activity as did overexpression of RBPJ. Consistent with this, knockdown of RBPJ in phenotypically modulated human aortic SMC enhanced endogenous SMC marker gene expression, an effect likely mediated by increased recruitment of serum response factor and Pol II to the SMC-specific promoters. In contrast, the depletion of RBPJ in differentiated transforming growth factor-β-treated SMC inhibited SMC-specific gene activation, supporting the idea that the effects of RBPJ/Notch signaling are context dependent.

CONCLUSIONS: Our results indicate that methylation-dependent binding of RBPJ to a GC repressor element can negatively regulate SM MHC promoter activity and that RBPJ can inhibit SMC marker gene expression in phenotypically modulated SMC. These results will have important implications on the regulation of SMC phenotype and on Notch-dependent transcription.
Entanglement-Breaking Indices
Creators: name: Lami, Ludovico
name: Giovannetti, Vittorio
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We study a set of new functionals (called entanglement--breaking indices) which characterize how many local iterations of a given (local) quantum channel are needed in order to completely destroy the entanglement between the system of interest over which the transformation is defined and an external ancilla. The possibility of contrasting the noisy effects introduced by the channel iterations via the action of intermediate ({\it filtering}) transformations is analyzed. We provide some examples in which our functionals can be exactly calculated. The differences between unitary and non-unitary filtering operations are analyzed showing that, at least for systems of dimension $d$ larger than or equal to 3, the non-unitary choice is preferable (the gap between the performances of the two cases being divergent in some cases). For $d=2$ (qubit case) on the contrary no evidences of the presence of such gap is revealed: we conjecture that for this special case unitary filtering transformations are optimal. The scenario in which more general filtering protocols are allowed is also discussed in some detail. The case of a depolarizing noise acting on a two--qubit system is exactly solved in a general case.
description: 17 pages, 2 figures. A new section on generalized filtering protocols has been added
Chiral three-nucleon forces and the evolution of correlations along the oxygen isotopic chain
Creators: name: Cipollone, A.
name: Barbieri, C.
name: Navrátil, P.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The impact of three-nucleon forces (3NFs) along the oxygen chain is investigated for the spectral distribution for attachment and removal of a nucleon, spectroscopic factors and matter radii. We employ self-consistent Green's function (SCGF) theory which allows a comprehensive calculation of the single particle spectral function. For the closed subshell isotopes, $^{14}$O, $^{16}$O, $^{22}$O, $^{24}$O and $^{28}$O, we perform calculations with the Dyson-ADC(3) method. The remaining open shell isotopes are studied using the newly developed Gorkov-SCGF formalism up to second order. We produce plots for the full-fledged spectral distributions. The spectroscopic factors for the dominant quasiparticle peaks are found to depend very little on the leading order (NNLO) chiral 3NFs. The latters have small impact on the calculated matter radii, which, however are consistently obtained smaller than experiment. Similarly, single particle spectra tend to be diluted with respect to experiment. This effect might hinder, to some extent, the onset of correlations and screen the quenching of calculated spectroscopic factors. The most important effects of 3NFs is thus the fine tuning of the energies for the dominant quasiparticle states, which govern the shell evolution and the position of driplines. Although present chiral NNLO 3NFs interactions do reproduce the binding energies correctly in this mass region, the details of the nuclear wave function remain at odd with the experiment showing too small radii and a too dilute single particle spectrum, similar to what already pointed out for larger masses. This suggests a lack of repulsion in the present model of NN+3N interactions which is mildly apparent already for masses in the A=14--28 range.
description: 13 pages, accepted for publication on Phys. Rev. C
NADPH Oxidase-Generated Reactive Oxygen Species Are Required for Stromal Cell-Derived Factor-1 -Stimulated Angiogenesis
Creators: name: Li, X.
name: Lockyer, P.
name: Patterson, C.
name: Pi, X.
name: Xie, L.
name: Portbury, A. L.
name: Kumar, S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Reactive oxygen species (ROS) act as signaling molecules during angiogenesis, however, the mechanisms used for such signaling events remain unclear. Stromal cell-derived factor-1α (SDF-1α) is one of the most potent angiogenic chemokines. Here we examined the role of ROS in the regulation of SDF-1α-dependent angiogenesis.
Additional file 4 of Enrichment of human nasopharyngeal bacteriome with bacteria from dust after short-term exposure to indoor environment: a pilot study
Creators: name: Konecna, Eva
name: Videnska, Petra
name: Buresova, Lucie
name: Urik, Milan
name: Smetanova, Sona
name: Smatana, Stanislav
name: Prokes, Roman
name: Lanickova, Barbara
name: Budinska, Eva
name: Klanova, Jana
name: Borilova Linhartova, Petra
Publisher: name: figshare
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 4. UpSetR plot. Visualization of bacterial genera intersections in dust and nasopharyngeal samples. UpSetR plot shows the presence of specific bacterial genera across tested groups in nasopharyngeal and dust samples. The UpSetR plot distinguishes unique and shared taxa. Genera with a group median value of at least three reads were defined as present in the group. Unassigned taxa were not involved.
Perivascular Adipose Tissue and Coronary Vascular Disease
Creators: name: Noblet, J. N.
name: Tune, J. D.
name: Sassoon, D. J.
name: Owen, M. K.
name: Conteh, A. M.
name: Goodwill, A. G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Coronary perivascular adipose tissue (PVAT) is a naturally occurring adipose tissue depot that normally surrounds the major coronary arteries on the surface of the heart. While originally thought to promote vascular health and integrity, there is a growing body of evidence to support that coronary PVAT displays a distinct phenotype relative to other adipose depots and is capable of producing local factors with the potential to augment coronary vascular tone, inflammation, and the initiation and progression of coronary artery disease. The purpose of the present review is outline previous findings regarding the cardiovascular effects of coronary PVAT and the potential mechanisms by which adipose-derived factors may influence coronary vascular function and the progression of atherogenesis.
Associations between personal care product use patterns and breast cancer risk among white and black women in the sister study
Creators: name: Engel, L.S.
name: Taylor, K.W.
name: Baird, D.D.
name: Sandler, D.P.
name: Herring, A.H.
name: Troester, M.A.
name: Nichols, H.B.
Publisher: name: Public Health Services, US Dept of Health and Human Services
Year: 2018

description: BACKGROUND: Many personal care products include chemicals that might act as endocrine disruptors and thus increase the risk of breast cancer. OBJECTIVE: We examined the association between usage patterns of beauty, hair, and skin-related personal care products and breast cancer incidence in the Sister Study, a national prospective cohort study (enrollment 2003–2009). METHODS: Non-Hispanic black (4,452) and white women (n = 42,453) were examined separately using latent class analysis (LCA) to identify groups of individuals with similar patterns of self-reported product use in three categories (beauty, skin, hair). Multivariable Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between product use and breast cancer incidence. RESULTS: A total of 2,326 women developed breast cancer during follow-up (average follow-up = 5:4 y). Among black women, none of the latent class hazard ratios was elevated, but there were <100 cases in any category, limiting power. Among white women, those classified as “moderate” and “frequent” users of beauty products had increased risk of breast cancer relative to “infrequent” users [HR = 1:13 (95% CI: 1.00, 1.27) and HR = 1:15 (95% CI: 1.02, 1.30), respectively]. Frequent users of skincare products also had increased risk of breast cancer relative to infrequent users [HR = 1:13 (95% CI: 1.00, 1.29)]. None of the hair product classes was associated with increased breast cancer risk. The associations with beauty and skin products were stronger in postmenopausal women than in premenopausal women, but not significantly so. CONCLUSIONS: This work generates novel hypotheses about personal care product use and breast cancer risk. Whether these results are due to specific chemicals or to other correlated behaviors needs to be evaluated. https://doi.org/10.1289/EHP1480.
Dynamic isoperimetry and the geometry of Lagrangian coherent structures
Creators: name: Froyland, Gary
Publisher: name: arXiv
Year: 2014
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 37C05, 37C10, 53A10

description: The study of transport and mixing processes in dynamical systems is particularly important for the analysis of mathematical models of physical systems. We propose a novel, direct geometric method to identify subsets of phase space that remain strongly coherent over a finite time duration. This new method is based on a dynamic extension of classical (static) isoperimetric problems; the latter are concerned with identifying submanifolds with the smallest boundary size relative to their volume. The present work introduces \emph{dynamic} isoperimetric problems; the study of sets with small boundary size relative to volume \emph{as they are evolved by a general dynamical system}. We formulate and prove dynamic versions of the fundamental (static) isoperimetric (in)equalities; a dynamic Federer-Fleming theorem and a dynamic Cheeger inequality. We introduce a new dynamic Laplacian operator and describe a computational method to identify coherent sets based on eigenfunctions of the dynamic Laplacian. Our results include formal mathematical statements concerning geometric properties of finite-time coherent sets, whose boundaries can be regarded as Lagrangian coherent structures. The computational advantages of our new approach are a well-separated spectrum for the dynamic Laplacian, and flexibility in appropriate numerical approximation methods. Finally, we demonstrate that the dynamic Laplacian operator can be realised as a zero-diffusion limit of a newly advanced probabilistic transfer operator method (Froyland, 2013) for finding coherent sets, which is based on small diffusion. Thus, the present approach sits naturally alongside the probabilistic approach (Froyland, 2013), and adds a formal geometric interpretation.
Metanetworks of artificially evolved regulatory networks
Creators: name: Danacı, Burçin
name: Erzan, Ayşe
Publisher: name: arXiv
Year: 2014
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Physics and Society (physics.soc-ph)
subject: Populations and Evolution (q-bio.PE)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: We study metanetworks arising in genotype and phenotype spaces, in the context of a model population of Boolean graphs evolved under selection for short dynamical attractors. We define the adjacency matrix of a graph as its genotype, which gets mutated in the course of evolution, while its phenotype is its set of dynamical attractors. Metanetworks in the genotype and phenotype spaces are formed, respectively, by genetic proximity and by phenotypic similarity, the latter weighted by the sizes of the basins of attraction of the shared attractors. We find that populations of evolved networks form giant clusters in genotype space, have Poissonian degree distributions but exhibit hierarchically organized $κ$-core decompositions. Nevertheless, at large scales, they form tree-like expander graphs. Random populations of Boolean graphs are typically so far removed from each other genetically that they cannot form a metanetwork. In phenotype space, the metanetworks of evolved populations are super robust both under the elimination of weak connections and random removal of nodes.
description: 15 pages, 27 figures
A nested case-control study of polychlorinated biphenyls, organochlorine pesticides, and thyroid cancer in the Janus Serum Bank cohort
Creators: name: Ward, M.H.
name: Sjödin, A.
name: Choo-Wosoba, H.
name: Grimsrud, T.K.
name: Albert, P.
name: Engel, L.S.
name: Lerro, C.C.
name: Jones, R.R.
name: Langseth, H.
Publisher: name: Academic Press Inc.
Year: 2018

description: Background: Polychlorinated biphenyls (PCBs) and organochlorine pesticides have been associated with altered thyroid hormone levels in humans, but their relationship with thyroid cancer is unknown. Methods: We conducted a nested case-control study of thyroid cancer in the Norwegian Janus Serum Bank cohort using pre-diagnostic blood samples from 1972 to 1985. Incident thyroid cancer (n = 108) was ascertained through 2008. Controls were matched 2:1 by age, date of blood draw, gender, and county. We used gas chromatography/mass spectrometry to quantify 36 PCB congeners and metabolites of pesticides DDT, chlordane, hexachlorocyclohexane, and hexachlorobenzene. PCBs and pesticide metabolites were evaluated individually and summed by degree of chlorination and parent compound, respectively. Odds ratios (OR) and 95% confidence intervals (CI) were computed using conditional logistic regression per specified increase in lipid-adjusted concentration. We additionally stratified analyses by birth cohort (1923–1932, 1933–1942, 1943–1957). Results: Increasing concentration of DDT metabolites (OR per 1000 ng/g = 0.80, 95%CI = 0.66–0.98) was inversely associated with thyroid cancer. Associations for PCBs were null or in inverse direction. We observed interactions for total PCBs, moderately-chlorinated PCBs, and chlordane metabolites with birth cohort (p ≤ 0.04). Among participants born 1943–1957, total PCBs (OR per 100 ng/g = 1.25, 95%CI = 1.00–1.56), moderately-chlorinated PCBs (OR per 100 ng/g = 1.31, 95%CI = 1.01–1.70), and chlordane metabolites (OR per 10 ng/g = 1.78, 95%CI = 1.09–2.93) were positively associated with thyroid cancer. For individuals born before 1943, associations were generally null or in the inverse direction. Conclusions: Emissions of PCBs and OC pesticides varied over time. Different risk patterns by birth cohort suggest the potential importance of timing of exposure in thyroid cancer risk. Further evaluation of these associations is warranted.
IPBES Invasive Alien Species Assessment, data management report for cross-chapter literature review on Indigenous Peoples and local communities and invasive alien species
Creators: name: Howard, Patricia L.
name: Ryan-Colton, Ellen
name: Ikegami, Makihiko
name: Lipinskaya, Tatsiana
name: Stoett, Peter
name: Saeedi, Hanieh
name: Rahlao, Sebataolo
name: Tawake, Alifereti
name: Tricarico, Elena
name: Ikeda, Tohru
name: Per, Esra
name: Pallewatta, P. K. T. Nirmalie S.
name: Hiremath, Ankila J.
name: Martinou, Angeliki F.-Kelly
name: Fernandez, Romina d.
name: Preda, Cristina
name: Sheppard, Andy W.
name: Egawa, Chika
name: Bwalya, Bridget
name: Rono, Betty
name: Ksenofontov, Stanislav
name: Shrestha, Bharat B.
name: Tambo, Justice A.
name: Puri, Rajindra
name: Fisher, Judith L.
Publisher: name: Zenodo
Year: 2023
Subjects: IPBES
Assessment
Invasive alien species
Data management report
Indigenous Peoples and local communities
ILK

description: In order to respond to the IPBES mandate on indigenous and local knowledge (ILK), and to the scoping document for the IPBES thematic assessment of invasive alien species (IAS) and their control, the expert group conducted a cross-chapter literature review on the relationships between invasive alien species (IAS) and indigenous peoples and local communities (IPLC). This literature review provides evidence on IPLC perception, and indigenous and local knowledge on trends, drivers, impacts, management and governance of invasive alien species.
The deepwater horizon oil spill coast guard cohort study: A cross-sectional study of acute respiratory health symptoms
Creators: name: Barrett, J.
name: Schwartz, E.G.
name: Olaiya, N.
name: Weems, L.
name: Engel, L.S.
name: Alexander, M.
name: Wang, L.
name: Rusiecki, J.A.
Publisher: name: Academic Press Inc.
Year: 2018

description: Introduction Over 8500 United States Coast Guard (USCG) personnel were deployed in response to the Deepwater Horizon (DWH) oil spill; however, human respiratory effects as a result of spill-related exposures are relatively unknown. Methods USCG personnel who responded to the DWH oil spill were queried via survey on exposures to crude oil and oil dispersant, and acute respiratory symptoms experienced during deployment. Adjusted log binomial regressions were used to calculate prevalence ratios (PRs) and 95% confidence intervals (CI), investigating the associations between oil spill exposures and respiratory symptoms. Results 4855 USCG personnel completed the survey. More than half (54.6%) and almost one-fourth (22.0%) of responders were exposed to crude oil and oil dispersants, respectively. Coughing was the most prevalent symptom (19.4%), followed by shortness of breath (5.5%), and wheezing (3.6%). Adjusted analyses showed an exposure-response relationship between increasing deployment duration and likelihood of coughing, shortness of breath, and wheezing in the pre-capping period. A similar pattern was observed in the post-capping period for coughing and wheezing. Adjusted analyses revealed increased PRs for coughing (PR=1.92), shortness of breath (PR=2.60), and wheezing (PR=2.68) for any oil exposure. Increasing frequency of inhalation of oil was associated with increased likelihood of all three respiratory symptoms. A similar pattern was observed for contact with oil dispersants for coughing and shortness of breath. The combination of both oil and oil dispersants presented associations that were much greater in magnitude than oil alone for coughing (PR=2.72), shortness of breath (PR=4.65), and wheezing (PR=5.06). Conclusions Results from the present study suggested strong relationships between oil and oil dispersant exposures and acute respiratory symptoms among disaster responders. Future prospective studies will be needed to confirm these findings.
Small Dense Low-Density Lipoprotein-Cholesterol Concentrations Predict Risk for Coronary Heart Disease: The Atherosclerosis Risk in Communities (ARIC) Study
Creators: name: Dodge, R. C.
name: Boerwinkle, E.
name: Couper, D.
name: Sun, W.
name: Crosby, J. R.
name: Gaubatz, J. W.
name: Hoogeveen, R. C.
name: Ballantyne, C. M.
name: Virani, S. S.
name: Jiang, J.
name: Kathiresan, S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: OBJECTIVE: To investigate the relationship between plasma levels of small dense low-density lipoprotein-cholesterol (sdLDL-C) and risk for incident coronary heart disease (CHD) in a prospective study among Atherosclerosis Risk in Communities (ARIC) study participants.

APPROACH AND RESULTS: Plasma sdLDL-C was measured in 11 419 men and women of the biracial ARIC study using a newly developed homogeneous assay. A proportional hazards model was used to examine the relationship among sdLDL-C, vascular risk factors, and risk for CHD events (n=1158) for a period of ≈11 years. Plasma sdLDL-C levels were strongly correlated with an atherogenic lipid profile and were higher in patients with diabetes mellitus than non-diabetes mellitus (49.6 versus 42.3 mg/dL; P<0.0001). In a model that included established risk factors, sdLDL-C was associated with incident CHD with a hazard ratio of 1.51 (95% confidence interval, 1.21-1.88) for the highest versus the lowest quartile, respectively. Even in individuals considered to be at low cardiovascular risk based on their LDL-C levels, sdLDL-C predicted risk for incident CHD (hazard ratio, 1.61; 95% confidence interval, 1.04-2.49). Genome-wide association analyses identified genetic variants in 8 loci associated with sdLDL-C levels. These loci were in or close to genes previously associated with risk for CHD. We discovered 1 novel locus, PCSK7, for which genetic variation was significantly associated with sdLDL-C and other lipid factors.

CONCLUSIONS: sdLDL-C was associated with incident CHD in ARIC study participants. The novel association of genetic variants in PCSK7 with sdLDL-C and other lipid traits may provide new insights into the role of this gene in lipid metabolism.
title: Φυσικά συστατικά στα αντηλιακά. Τοπικές συνθέσεις και αξιολόγηση in vitro του δείκτη SPF
title: Natural ingredients in sunscreens. Topical compositions and in vitro evaluation of SPF
titleType: AlternativeTitle
Creators: name: Γιαννακοπούλου, Γεωργία
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2022
Subjects: Αντηλιακό
Πρόπολη
Ενισχυτικό SPF
Εκχύλισμα echinacea purpurea

description: Η συνεχής έκθεση στη UV (Ultraviolet-Υπεριώδης) ακτινοβολία έχει δυσάρεστες συνέπειες στην υγεία του ατόμου, όπως η καταστροφή του DNA, το οξειδωτικό stress εξ αιτίας του σχηματισμού ελευθέρων ριζών κ.ο.κ. Για την προστασία από την UV ακτινοβολία, πολλές φορές δεν επαρκούν τα απλά προστατευτικά μέσα (γυαλιά, καπέλο, ρούχα), συνεπώς απαιτείται η τοπική χρήση αντηλιακών προϊόντων, τα οποία περιέχουν αντηλιακά φίλτρα που απορροφούν, σκεδάζουν ή ανακλούν την UV ακτινοβολία. Οι ουσίες αυτές αποτελούν τα δραστικά συστατικά των αντηλιακών προϊόντων, ωστόσο πολλές από αυτές μπορεί να προκαλέσουν ανεπιθύμητες ενέργειες τόσο στους χρήστες όσο και στο περιβάλλον. Ως εκ τούτου, έχει δημιουργηθεί η ανάγκη να βρεθούν φυσικά συστατικά, όπως φυτικά εκχυλίσματα, τα οποία εφόσον προστεθούν στα αντηλιακά προϊόντα, μπορεί να ενισχύσουν την προστασία απέναντι στην UV ακτινοβολία, μέσω της αύξησης του SPF (Sun Protection Factor-Αντηλιακός Δείκτης). Το όφελος από την προσθήκη αυτών των συστατικών είναι η μείωση της συγκέντρωσης των UV φίλτρων και του περιβαλλοντικού αποτυπώματος που προκύπτει. Στην παρούσα μελέτη, εξετάστηκε η επίδραση που έχει η προσθήκη ελαίου πρόπολης και εκχυλίσματος από το φυτό Echinacea purpurea σε μια σύνθεση με οργανικά και ανόργανα UV φίλτρα. Πιο συγκεκριμένα, εξετάστηκε η επίδραση του ελαίου πρόπολης και του εκχυλίσματος από το φυτό Echinacea purpurea καθώς και του συνδυασμού τους στην αύξηση του SPF.
Bifidobacterium Mechanisms of Immune Modulation and Tolerance
Creators: name: Ma, Bing
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 320408
subject: Transplantation immunology

description: Samuel J Gavzy1,2, Allison Kensiski1, Zachariah L Lee1, Emmanuel F Mongodin3#, Bing Ma3,4,*, Jonathan S Bromberg1,2,4,*1 Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD, USA2 Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA3 Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA4. Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA# Current address: Division of Lung Diseases, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, Maryland, USA* Co-corresponding authors
Gap Junction Coupling Is Required for Tumor Cell Migration Through Lymphatic Endothelium
Creators: name: Karpinich, N. O.
name: Caron, K. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The lymphatic vasculature is a well-established conduit for metastasis, but the mechanisms by which tumor cells interact with lymphatic endothelial cells (LECs) to facilitate escape remain poorly understood. Elevated levels of the lymphangiogenic peptide adrenomedullin (AM) are found in many tumors and we previously characterized that its expression is necessary for lymphatic vessel growth within both tumors and sentinel lymph nodes and for distant metastasis.
title: Φυτικά υποκατάστατα γάλακτος, πλεονεκτήματα - μειονεκτήματα στην παραγωγή προϊόντων
title: Plant-based milk substitutes, advantages - disadvantages in the production of products
titleType: AlternativeTitle
Creators: name: Παπαπαναγιώτου, Ευαγγελία
name: Σουλάνι, Αικατερίνη
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2022
Subjects: Σόγια
Φυτικά υποκατάστατα γάλακτος

description: Τα τελευταία χρόνια υπάρχει μεγάλη τάση προς την κατανάλωση εναλλακτικών προϊόντων. Μία πολύ μεγάλη μερίδα ανθρώπων, επιλέγει πιο υγιεινή διατροφή στηριζόμενη κυρίως σε φυτικές ίνες (λ.χ όσπρια), με σκοπό να βελτιώσει την ποιότητα της υγείας τους. Άλλοι επιλέγουν να τρέφονται μόνο με φυτικές τροφές λόγω ιδεολογίας που συμπεριλαμβάνει την προστασία του περιβάλλοντος και των ζώων. Άλλοι πάλι, έχουν την τάση να στρέφονται σε εναλλακτικές τροφές λόγω αλλεργιών ή δυσανεξιών που μπορεί να αντιμετωπίζουν. Για όλους αυτούς τους λόγους η βιομηχανία φυτικών υποκατάστατων και κατ’ επέκταση η παραγωγή προϊόντων από φυτικά υποκατάστατα συνεχώς αυξάνεται. Τα φυτικά υποκατάστατα γάλακτος ή φυτικά εκχυλίσματα είναι υδατοδιαλυτά εκχυλίσματα οσπρίων, ελαιούχων σπόρων, δημητριακών ή ψευδοδημητριακών που μοιάζουν με το αγελαδινό γάλα, δημιουργώντας έτσι μία εναλλακτική λύση για το αγελαδινό γάλα. Στην παρούσα πτυχιακή εργασία, που αποτελεί βιβλιογραφική ανασκόπηση, αναλύονται οι πρώτες ύλες που χρησιμοποιούνται για να παραχθούν τα φυτικά υποκατάστατα γάλακτος (σόγια, αμύγδαλο, καρύδα) καθώς και τα φυτικά υποκατάστατα που προκύπτουν από αυτές (γάλα σόγιας, γάλα αμυγδάλου, γάλα καρύδας). Επιπλέον, παρουσιάζεται η διατροφική σύσταση αυτών και η σύγκριση τους με το γάλα αγελάδας όπου και διαπιστώθηκε ότι έχουν χαμηλότερη πρωτεΐνη, ασβέστιο και βιταμίνη D, αλλά υψηλότερη περιεκτικότητα νατρίου. Έκτος από αυτά, αναλύονται και άλλα υποκατάστατα που προκύπτουν όπως ζυμωμένα φυτικά προϊόντα, γιαούρτι, φυτικά τυριά, τόφου, φυτικό παγωτό κ.τ.λ.. Τέλος, αναλύονται οι τάσεις της αγοράς ως προς τα φυτικά υποκατάστατα και γίνεται σύγκριση των γαλακτοκομικών προϊόντων με τα φυτικά υποκατάστατα ως προς τα διατροφικά, δομικά και τα οργανοληπτικά χαρακτηριστικά τους, ενώ παρουσιάζονται τα μειονεκτήματα και τα πλεονεκτήματα αυτών.
Inhibition of Diaphanous Formin Signaling In Vivo Impairs Cardiovascular Development and Alters Smooth Muscle Cell PhenotypeSignificance
Creators: name: Mack, Christopher P.
name: Weise-Cross, Laura
name: Taylor, Joan M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: We and others have previously shown that RhoA-dependent stimulation of myocardin related transcription factor (MRTF) nuclear localization promotes smooth muscle cell (SMC) marker gene expression. The goal of the present study was to provide direct in vivo evidence that actin polymerization by the diaphanous-related formins contributes to the regulation of SMC differentiation and/or phenotype.
title: Intellectual property in the digital age
Creators: name: Ubaydullaeva, Anna
name: Rustambekov, Islambek
name: Gulyamov, Said
Publisher: name: Roma Tre University
publisherIdentifier: https://ror.org/05vf0dg29
publisherIdentifierScheme: ROR
Year: 2024

description:

L'era digitale ha rivoluzionato il regno della proprietà intellettuale, portando sia opportunità senza precedenti che sfide significative. “La proprietà intellettuale nell'era digitale” si addentra nelle complessità di questa trasformazione, esplorando l'impatto delle tecnologie digitali sulla legge e sulla pratica della proprietà intellettuale. Il libro copre un'ampia gamma di argomenti, tra cui la protezione dei contenuti digitali, l’esecuzione dei diritti di proprietà intellettuale online e il ruolo delle tecnologie emergenti come l'intelligenza artificiale e la blockchain nella gestione della proprietà intellettuale. Attraverso un mix di analisi teorica e casi pratici, questo libro fornisce una comprensione approfondita di come la digitalizzazione stia influenzando la proprietà intellettuale, offrendo spunti preziosi per professionisti legali, accademici e politici.
Postdiagnosis changes in cigarette smoking and survival following breast cancer
Creators: name: Bradshaw, P.T.
name: Steck, S.E.
name: Engel, L.S.
name: Conway, K.
name: Gammon, M.D.
name: Parada, H., Jr
name: Neugut, A.I.
name: Santella, R.M.
name: Teitelbaum, S.L.
Publisher: name: Oxford University Press
Year: 2017

description: Background: The purpose of this study was to examine whether at-diagnosis smoking and postdiagnosis changes in smoking within five years after breast cancer were associated with long-termall-cause and breast cancer-specific mortality. Methods: A population-based cohort of 1508 women diagnosed with first primary in situ or invasive breast cancer in 1996 to 1997 were interviewed shortly after diagnosis and again approximately five years later to assess smoking history. Participants were followed for vital status through December 31, 2014. After 18+ years of follow-up, 597 deaths were identified, 237 of which were breast cancer related. Multivariable Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: Compared with never smokers, risk of all-cause mortality was elevated among the 19% of at-diagnosis smokers (HR=1.69, 95% CI=1.36 to 2.11), those who smoked 20 or more cigarettes per day (HR=1.85, 95% CI=1.42 to 2.40), women who had smoked for 30 or more years (HR=1.62, 95% CI=1.28 to 2.05), and women who had smoked 30 or more pack-years (HR=1.82, 95% CI=1.39 to 2.37). Risk of all-cause mortality was further increased among the 8% of women who were at-/postdiagnosis smokers (HR=2.30, 95% CI=1.56 to 3.39) but was attenuated among the 11% women who quit smoking after diagnosis (HR=1.83, 95% CI=1.32 to 2.52). Compared with never smokers, breast cancer-specific mortality risk was elevated 60% (HR=1.60, 95% CI=0.79 to 3.23) among at-/postdiagnosis current smokers, but the confidence interval included the null value and elevated 175% (HR=2.75, 95% CI=1.26 to 5.99) when we considered postdiagnosis cumulative pack-years. Conclusions: Smoking negatively impacts long-term survival after breast cancer. Postdiagnosis cessation of smoking may reduce the risk of all-cause mortality. Breast cancer survivors may benefit from aggressive smoking cessation programs starting as early as the time of diagnosis.
Simple rules for establishment of effective marine protected areas in an age-structured metapopulation
Creators: name: Takashina, Nao
Publisher: name: arXiv
Year: 2015
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: FOS: Biological sciences

description: The implementation of effective protected areas is one of the central goals of modern conservation biology. In the context of fisheries management and marine ecosystem conservation, marine reserves often play a significant role to achieve sustainable fisheries management. Consequently, a substantial number of studies have been conducted to establish broad rules for the creation of MPAs, or to test the effects of MPAs in specific regions. However, there still exist many challenges for implementing MPAs that are effective at meeting their goals. Deducing theoretical conditions guaranteeing that the introduction of marine reserves will increase fisheries yields in age-structured population dynamics is one such challenge. To derive such conditions, a simple mathematical model is developed that follows an age-structured metapopulation dynamics of a sedentary species. The obtained results suggest that a sufficiently high fishing mortality rate and moderate recruitment success of an individual's eggs is a necessary for marine reserves to increase fisheries yields. The numerical calculations were conducted with the parameters of red abalone (Haliotis rufescens) to visualize and to check validity of the analytical results. They show good agreement with the analytical results, as well as the results obtained in the previous works.
description: 16 pages, 2 figures
Additional file 6 of Enrichment of human nasopharyngeal bacteriome with bacteria from dust after short-term exposure to indoor environment: a pilot study
Creators: name: Konecna, Eva
name: Videnska, Petra
name: Buresova, Lucie
name: Urik, Milan
name: Smetanova, Sona
name: Smatana, Stanislav
name: Prokes, Roman
name: Lanickova, Barbara
name: Budinska, Eva
name: Klanova, Jana
name: Borilova Linhartova, Petra
Publisher: name: figshare
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 6. Dust sampling head.
Examples of special quadratic birational transformations into complete intersections of quadrics
Creators: name: Staglianò, Giovanni
Publisher: name: arXiv
Year: 2014
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14E05, 14Q15, 14J30

description: In our previous works (2012, 2013), we provided a finite list of properties characterizing all potential types of quadratic birational transformations of a projective space into a factorial variety, whose base locus is smooth and irreducible. However, some existence problems remained open. Among them one had to prove that the image of a given transformation was factorial, but in two particular situations, even the mere existence of the transformation was left as an open problem. In this paper, we use computer algebra methods to construct explicitly four examples of such transformations; two of them were among those for which it was not known that the image was factorial, and the other two show the existence of the two above referred transformations.
description: Accepted for publication in the Journal of Symbolic Computation
Lean and Obese Coronary Perivascular Adipose Tissue Impairs Vasodilation via Differential Inhibition of Vascular Smooth Muscle K+ Channels
Creators: name: Noblet, J. N.
name: Owen, M. K.
name: Sassoon, D. J.
name: Goodwill, A. G.
name: Tune, J. D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The effects of coronary perivascular adipose tissue (PVAT) on vasomotor tone are influenced by an obese phenotype and are distinct from other adipose tissue depots. The purpose of this investigation was to examine the effects of lean and obese coronary PVAT on end-effector mechanisms of coronary vasodilation and to identify potential factors involved.
Evaluation of the Majorana Phases of a General Majorana Neutrino Mass Matrix: Testability of hierarchical Flavour Models
Creators: name: Samanta, Rome
name: Chakraborty, Mainak
name: Ghosal, Ambar
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We evaluate the Majorana phases for a general $3\times3$ complex symmetric neutrino mass matrix on the basis of Mohapatra-Rodejohann's phase convention using the three rephasing invariant quantities $I_{12}$, $I_{13}$ and $I_{23}$ proposed by Sarkar and Singh. We find them interesting as they allow us to evaluate each Majorana phase in a model independent way even if one eigenvalue is zero. Utilizing the solution of a general complex symmetric mass matrix for eigenvalues and mixing angles we determine the Majorana phases for both the hierarchies, normal and inverted, taking into account the constraints from neutrino oscillation global fit data as well as bound on the sum of the three light neutrino masses ($Σ_im_i$) and the neutrinoless double beta decay ($ββ_{0ν}$) parameter $|m_{11}|$. This methodology of finding the Majorana phases is applied thereafter in some predictive models for both the hierarchical cases (normal and inverted) to evaluate the corresponding Majorana phases and it is shown that all the sub cases presented in inverted hierarchy section can be realized in a model with texture zeros and scaling ansatz within the framework of inverse seesaw although one of the sub case following the normal hierarchy is yet to be established. Except the case of quasi degenerate neutrinos, the methodology obtained in this work is able to evaluate the corresponding Majorana phases, given any model of neutrino masses.
description: 27 pages, 16 figures, 4 tables, to appear in NPB
Plasma Levels of Soluble Interleukin-2 Receptor αSignificance: Associations With Clinical Cardiovascular Events and Genome-Wide Association Scan
Creators: name: Li, Jin
name: Tracy, Russell P.
name: Harris, Tamara B.
name: Lange, Ethan M.
name: Nalls, Mike A.
name: Jenny, Nancy Swords
name: Valdar, William
name: Lange, Leslie A.
name: Sabourin, Jeremy
name: Walston, Jeremy
name: Cushman, Mary
name: Reiner, Alex P.
name: Psaty, Bruce M.
name: Liu, Yongmei
name: Durda, Peter
name: Mychaleckyj, Josyf C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Interleukin-2 receptor subunit alpha (IL-2Rα) regulates lymphocyte activation, which plays an important role in atherosclerosis. Associations between soluble IL-2Rα and cardiovascular disease (CVD) have not been widely studied and little is known about the genetic determinants of sIL-2Rα levels.
Platelet Inhibitors Reduce Rupture in a Mouse Model of Established Abdominal Aortic AneurysmSignificance
Creators: name: Edwards, Todd L.
name: Owens, A. Phillip
name: Geddings, Julia E.
name: Wei, Wei-Qi
name: Daugherty, Alan
name: Jahangir, Eiman
name: Antoniak, Silvio
name: Boulaftali, Yacine
name: Bergmeier, Wolfgang
name: Mackman, Nigel
name: Denny, Joshua C.
name: Sampson, Uchechukwu K.A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Rupture of abdominal aortic aneurysms (AAAs) causes a high morbidity and mortality in the elderly population. Platelet-rich thrombi form on the surface of aneurysms and may contribute to disease progression. In this study, we used a pharmacologic approach to examine a role of platelets in established aneurysms induced by angiotensin II (AngII) infusion into hypercholesterolemic mice.
Mental health indicators associated with oil spill response and clean-up: cross-sectional analysis of the GuLF STUDY cohort
Creators: name: Galea, S.
name: Payne, J.
name: Lowe, S.R.
name: Sandler, D.P.
name: Jackson, W.B.
name: Engel, L.S.
name: Kwok, R.K.
name: McGrath, J.A.
name: Curry, M.D.
Publisher: name: Elsevier Ltd
Year: 2017

description: Background Adverse mental health effects have been reported following oil spills but few studies have identified specific responsible attributes of the clean-up experience. We aimed to analyse the effects of the 2010 Deepwater Horizon (Gulf of Mexico) disaster on the mental health of individuals involved in oil spill response and clean-up. Methods We used data from the Gulf Long-term Follow-up Study, a cohort of workers and volunteers involved in oil spill clean-up after the Deepwater Horizon disaster. We included 8968 workers (hired after completing training for oil spill response and clean-up) and 2225 non-workers (completed training but were not hired) who completed a Patient Health Questionnaire-8 and four-item Primary Care PTSD Screen to assess for probable depression and post-traumatic stress disorder (PTSD) indicators. Participants were recruited between March 28, 2011, and March 29, 2013. The mental health indicators were assessed at home visits done between May 12, 2011, and May 15, 2013. We used regression models to analyse the effect of potentially stressful job experiences, job type, and total hydrocarbon exposure on mental health indicators. Findings Oil spill response and clean-up work was associated with increased prevalence of depression (prevalence ratio [PR] 1·22, 95% CI 1·08–1·37) and PTSD (PR 1·35, 95% CI 1·07–1·71). Among workers, individuals who reported smelling oil, dispersants, or cleaning chemicals had an elevated prevalence of depression (1·56, 1·37–1·78) and PTSD (2·25, 1·71–2·96). Stopping work because of the heat was also associated with depression (1·37, 1·23–1·53) and PTSD (1·41, 1·15–1·74), as was working as a commercial fisherman before the spill (1·38, 1·21–1·57; and 2·01, 1·58–2·55, respectively). An increase in exposure to total hydrocarbons appeared to be associated with depression and PTSD, but after taking into account oil spill job experiences, only the association between the highest amount of total hydrocarbons and PTSD remained (1·75, 1·11–2·76). Interpretation Oil spill clean-up workers with high amounts of total hydrocarbon exposure or potentially stressful job experiences had an increased prevalence of depression and PTSD. These findings provide evidence that response and clean-up work is associated with adverse psychological effects and suggest the need for mental health services both before and after the event. Funding National Institutes of Health (NIH) Common Fund and the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences.
Five-dimensional Janis-Newman algorithm
Creators: name: Erbin, Harold
name: Heurtier, Lucien
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The Janis-Newman algorithm has been shown to be successful in finding new sta- tionary solutions of four-dimensional gravity. Attempts for a generalization to higher dimensions have already been found for the restricted cases with only one angular mo- mentum. In this paper we propose an extension of this algorithm to five dimensions with two angular momenta - using the prescription of G. Giampieri - through two specific examples, that are the Myers-Perry and BMPV black holes. We also discuss possible enlargements of our prescriptions to other dimensions and maximal number of angular momenta, and show how dimensions higher than six appear to be much more challenging to treat within this framework. Nonetheless this general algorithm provides a unification of the formulation in d = 3, 4, 5 of the Janis-Newman algorithm, from which which expose several examples including the BTZ black hole.
description: 27 pages