cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Automated calibration of consensus weighted distance-based clustering approaches using sharp
Creators: name: Bodinier, Barbara
name: Vuckovic, Dragana
name: Rodrigues, Sabrina
name: Filippi, Sarah
name: Chiquet, Julien
name: Chadeau-Hyam, Marc
Publisher: name: arXiv
Year: 2023
Subjects: subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: In consensus clustering, a clustering algorithm is used in combination with a subsampling procedure to detect stable clusters. Previous studies on both simulated and real data suggest that consensus clustering outperforms native algorithms. We extend here consensus clustering to allow for attribute weighting in the calculation of pairwise distances using existing regularised approaches. We propose a procedure for the calibration of the number of clusters (and regularisation parameter) by maximising a novel consensus score calculated directly from consensus clustering outputs, making it extremely computationally competitive. Our simulation study shows better clustering performances of (i) models calibrated by maximising our consensus score compared to existing calibration scores, and (ii) weighted compared to unweighted approaches in the presence of features that do not contribute to cluster definition. Application on real gene expression data measured in lung tissue reveals clear clusters corresponding to different lung cancer subtypes. The R package sharp (version 1.4.0) is available on CRAN.
Hole spin dynamics and hole $g$ factor anisotropy in coupled quantum well systems
Creators: name: Gradl, C.
name: Kempf, M.
name: Schuh, D.
name: Bougeard, D.
name: Winkler, R.
name: Schüller, C.
name: Korn, T.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Due to its p-like character, the valence band in GaAs-based heterostructures offers rich and complex spin-dependent phenomena. One manifestation is the large anisotropy of Zeeman spin splitting. Using undoped, coupled quantum wells (QWs), we examine this anisotropy by comparing the hole spin dynamics for high- and low-symmetry crystallographic orientations of the QWs. We directly measure the hole $g$ factor via time-resolved Kerr rotation, and for the low-symmetry crystallographic orientations (110) and (113a), we observe a large in-plane anisotropy of the hole $g$ factor, in good agreement with our theoretical calculations. Using resonant spin amplification, we also observe an anisotropy of the hole spin dephasing in the (110)-grown structure, indicating that crystal symmetry may be used to control hole spin dynamics.
How do professional development programs on comparing solution methods and classroom discourse affect students' achievement in mathematics? The mediating role of students’ subject matter justifications
Creators: name: Mok, Sog Yee
name: Hämmerle, Christian S.
name: Rüede, Christian
name: Staub, Fritz
Publisher: name: My University
Year: 2022
Subjects: subject: Classroom talk
subject: Comparing solution methods
subject: Teachers' professional development
subject: Reasoning in mathematics
subject: 370 - Erziehung, Schul- und Bildungswesen

description: Comparing solution methods fosters strategy flexibility in equation solving. Productive classroom discourse such as Accountable Talk (AT) orchestrated by teachers can improve students’ justifications during classroom discussions and achievement. Do students’ subject matter justifications during classroom discourse mediate the effect of teachers’ professional development (PD) programs focused on comparing and AT on students’ mathematics achievement? We investigated whether two PD programs (comparing or comparing+AT) compared to a control group increased the number of students justifications, and whether this affected mathematics achievement (strategy flexibility, procedural knowledge, and conceptual knowledge). The study (739 9th and 10th grade students in 39 classes) had an experimental pre-post control group design. Both PD programs significantly increased students justifications compared to the control group. The results of our multilevel path models showed significant small mediation effects in the comparing+AT group on procedural and conceptual knowledge. No mediation effects were found in the comparing group.
MPEC 2023-D53 : SEVEN NEW TNOS
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: SEVEN NEW TNOS

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Vittorio Emanuele Orlando e la “questione romana”
Creators: name: Melillo, Leone
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2018

description: SOMMARIO: 1. Premessa – 2. Dalle “condizioni svariate e complesse della coscienza giuridica del popolo” alla “sovranità dello Stato” – 3. Il mancato accordo politico – 4. Conclusione. Vittorio Emanuele Orlando and the "Roman question" ABSTRACT: The motivation that leads Orlando to negotiate the solution of the “Roman Question” with Monsignor Bonaventura Cerretti, that he “met” in Paris, as “sent” by Benedict XV, focuses on the work of political agreement, on the “crisis” of the “Orlando ministry” and, therefore, on the Lateran Pacts of 11th February 1929, which mark the overcoming of a politics, founded on the “law of guarantees”, and give a “not very different text from that of Orlando - Cerretti’s one”.
description: Stato, Chiese e pluralismo confessionale, 2018: 12 febbraio
title: Αξιολόγηση πολιτισμικής ικανότητας προπτυχιακών φοιτητών νοσηλευτικής Τ.Ε.Ι. Θεσσαλίας
titleType: AlternativeTitle
title: Assessment of cultural competence in undergraduate TEI of Thessaly nursing students
Creators: name: Γκλιμπάτσα, Νεκταρία
Publisher: name: University of Thessaly
Year: 2018
Subjects: subject: Διαπολιτισμική νοσηλευτική
subject: Διαπολιτισμική νοσηλευτική -- Εκπαίδευση
subject: Πολιτιστική ικανότητα -- Εκπαίδευση

description: Σημείωση: διατίθεται συμπληρωματικό υλικό σε ξεχωριστό αρχείο.
Green's functions of multiband non-Hermitian systems
Creators: name: Hu, Yu-Min
name: Wang, Zhong
Publisher: name: arXiv
Year: 2023
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Optics (physics.optics)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Green's functions of non-Hermitian systems play a fundamental role in various dynamical processes. Because non-Hermitian systems are sensitive to boundary conditions due to the non-Hermitian skin effect, open-boundary Green's functions are closely related to the non-Bloch band theory. While the exact formula of open-boundary Green's functions in single-band non-Hermitian systems proves to be an integral along the generalized Brillouin zone (GBZ), the proper generalization in generic multiband systems remains unclear. In this work, we derive a formula of open-boundary Green's functions in multiband non-Hermitian systems by viewing the multiband GBZ on the Riemann surface. This formula can be applied to describe directional amplification in multiband systems, which can be verified at various experimental platforms.
description: 8 pages, 4 figures
Determination of mass and orbital parameters of a low-mass star HD 213597B
Creators: name: Chaturvedi, Priyanka
name: Deshpande, Rohit
name: Dixit, Vaibhav
name: Roy, Arpita
name: Chakraborty, Abhijit
name: Mahadevan, Suvrath
name: Anandarao, B. G.
name: Hebb, Leslie
name: Janardhan, P.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: HD 213597 is an eclipsing binary system which was detected by the STEREO spacecraft and was speculated to host a low-mass stellar companion. We used high-resolution spectroscopy with the 10-m Hobby-Eberly Telescope and the 1.2-m telescope in Mt Abu for radial velocity (RV) measurements of this source. We performed aperture photometry for this star on the STEREO archival data and thereby confirm the transit signature. We also did follow-up ground-based photometry with a 10-inch telescope from Mt Abu. The spectroscopic RV semi-amplitude of the primary (33.39 km s^-1) indicates that the secondary is an M dwarf making the system a short period F+M eclipsing binary. These RVs along with the inclination derived from our combined photometric analysis (i=84.9 degree), enable us to estimate the mass of the secondary as M_B ~ 0.286 M_sun and radius as R_B ~ 0.344 R_sun using an estimated mass M_A ~ 1.3 M_sun and radius R_B ~ 1.97 R_sun of the primary. Our spectral analysis returned the following parameters: T_eff = 6625 +/-121 K, [Fe/H] = -0.095 +\-0.08 and log(g) = 3.72 +/-0.22 for the primary. When log(g) is constrained to a value of 3.96, we derive T_eff = 6753 +/-52 K and [Fe/H] = -0.025+\-0.05.
description: 22 pages, 3 figures, Accepted for publication in MNRAS
The Effect of Introducing the U.S. Reinsurance System to the Korean Crop Insurance Program
Creators: name: Kang, Sujin
name: Kang, Sujin
Publisher: name: Unknown
Year: 2017
Subjects: subject: Risk and Uncertainty
subject: crop insurance
subject: government reinsurance program
subject: default risk

description: This paper is aimed towards evaluating an effectiveness of integrating health and social care for the elderly in rural areas in Korea. To quantitatively analyze the effectiveness of integrating care on care recipients’ satisfaction and care costs, the data were collected directly from two rural provinces where integrating health and social care for older people is implemented. Specifically, I used the collected data such as integrating care recipients' social care related quality of life (SCRQOL), the care recipients' demographic and socio-economic characteristics, hours of integrating care services to receive, and the care recipients' health conditions. Additionally budget data on integrating care in the two provinces are also obtained. Based on the aforementioned data, IV estimation for SCRQOL was employed, and then using this estimation, the optimal trajectory of service hours for the integrating care was calibrated. The results show that integrating health and social care improves care recipients’ SCRQOL. However cost effectiveness of the integrating care is not achieved under given budgets. This study suggests that the integrating care should be extended to achieve the optimal level of it under given budgets.
OPTIMETA - strengthening the Open Access publishing system through open citations and spatiotemporal metadata
Creators: name: Hauschke, Christian
name: Nüst, Daniel
name: Yücel, Gazi
name: Cordts, Anette
Publisher: name: Zenodo
Year: 2022
Subjects: open research information
OPTIMETA
open citations
spatio-temporal metadata
open access publishing

description: Presentation at the conference "Open science and innovation in Ukraine 2022" (https://doi.org/10.25798/dqea-2r89)
Gemini Planet Imager One Button Approach
Creators: name: Dunn, Jennifer
name: Kerley, Dan
name: Saddlemyer, Leslie
name: Smith, Malcolm
name: Wooff, Robert
name: Savransky, Dmitry
name: Palmer, Dave
name: Macintosh, Bruce
name: Weiss, Jason
name: Quiroz, Carlos
name: Rantakyrö, Fredrik T.
name: Goodsell, Stephen J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The Gemini Planet Imager (GPI) is an "extreme" adaptive optics coronagraph system that is now on the Gemini South telescope in Chile. This instrument is composed of three different systems that historically have been separate instruments. These systems are the extreme Adaptive Optics system, with deformable mirrors, including a high-order 64x64 element MEMS system; the Science Instrument, which is a near-infrared integral field spectrograph; and the Calibration system, a precision IR wavefront sensor that also holds key coronagraph components. Each system coordinates actions that require precise timing. The observatory is responsible for starting these actions and has typically done this asynchronously across independent systems. Despite this complexity we strived to provide an interface that is as close to a one-button approach as possible. This paper will describe the sequencing of these systems both internally and externally through the observatory.
description: 9 pages, 2 figures. Proceedings of the SPIE, 9147-190
A systematic literature review of the economic and healthcare resource burden of cytomegalovirus
Creators: name: Diaz-Decaro, John
name: Myers, Evan
name: Mucha, Jacek
name: Neumann, Monika
name: Lewandowski, Witold
name: Kaczanowska, Magdalena
name: Schmidt, Elvira
name: Natenshon, Andrew
name: Talarico, Carla
name: Buck, Philip O.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Cytomegalovirus (CMV) can infect individuals at any age, including infants, who may contract it from infected mothers (congenital CMV [cCMV]). Whereas CMV infection is typically asymptomatic or causes mild illness in healthy individuals, infection can result in severe outcomes in immunocompromised individuals and in infants with cCMV. This systematic review aims to characterize the economic impact of CMV and cCMV infections. Medline, Embase, and LILACS databases were searched for publications reporting the economic impact of cCMV and CMV infections across all age groups. Manuscripts published between 2010 and 2020 from Australia, Latin America, Canada, Europe, Israel, Japan, the United States, and global (international, worldwide) studies were included; congress materials were excluded. Outcomes of interest included cCMV- and CMV-attributable direct costs/charges, resource utilization, and indirect/societal costs. Of 751 records identified, 518 were excluded based on duplication, population, outcome, study design, or country. Overall, 55 articles were eligible for full-text review; 25 were further excluded due to population, outcome, study design, or congress abstract. Two publications were additionally identified, resulting in economic impact data compiled from 32 publications. Of these, 24 publications reported cost studies of cCMV or CMV, including evaluation of direct costs/charges, healthcare resource utilization, and indirect/societal costs, and 7 publications reported economic evaluations of interventions. The populations, methods and outcomes used across these studies varied widely. CMV and cCMV infections impose a considerable economic impact on different countries, populations, and outcomes. There are substantial evidence gaps where further research is warranted.
Theoretical study of thorium monoxide for the electron electric dipole moment search, II: Electronic properties of $H^3Δ_1$ in ThO
Creators: name: Skripnikov, L. V.
name: Titov, A. V.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Recently an improved limits on the electron electric dipole moment, \eEDM, and dimensionless constant, $k_{T,P}$, characterizing the strength of the T,P-odd pseudoscalar$-$scalar electron$-$nucleus neutral current interaction in the $H^3Δ_1$ state of ThO molecule were obtained by ACME collaboration [Science 343, 269 (2014)]. The interpretation of the experiment in terms of fundamental quantities \eEDM\ and $k_{T,P}$ is based on the results of theoretical study of appropriate ThO characteristics, the effective electric field acting on electron, \Eeff, and a parameter of the T,P-odd pseudoscalar$-$scalar interaction, $W_{T,P}$, given in [J.Chem.Phys.\ 139, 221103 (2013)] by St.Petersburg group. To reduce the uncertainties of the given limits we report improved calculations of the molecular state$-$specific quantities \Eeff, 81.5~GV/cm, and $W_{T,P}$, 112~kHz, with the uncertainty within 7\% of the magnitudes. Thus, the values recommended to use for the upper limits of the quantities are 75.8~GV/cm and 104~kHz, correspondingly. The hyperfine structure constant, molecule-frame dipole moment of the $H^3Δ_1$ state and $H^3Δ_1\to X^1Σ^+$ transition energy which, in general, can serve as a measure of reliability of the obtained \Eeff\ and $W_{T,P}$ values are also calculated. Besides we report the first calculation of g-factor for the $H^3Δ_1$ state of ThO. The results are compared to the earlier experimental and theoretical studies, and a detailed analysis of uncertainties of the calculations is given.
Cross-fitted instrument: A blueprint for one-sample Mendelian randomization.
Creators: name: Denault, William RP
name: Bohlin, Jon
name: Page, Christian M
name: Burgess, Stephen
name: Jugessur, Astanand
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: subject: Research Article
subject: Biology and life sciences
subject: Research and analysis methods
subject: Physical sciences
subject: FOS: Physical sciences
subject: People and places

description: Bias from weak instruments may undermine the ability to estimate causal effects in instrumental variable regression (IVR). We present here a new approach to handling weak instrument bias through the application of a new type of instrumental variable coined 'Cross-Fitted Instrument' (CFI). CFI splits the data at random and estimates the impact of the instrument on the exposure in each partition. These estimates are then used to perform an IVR on each partition. We adapt CFI to the Mendelian randomization (MR) setting and term this adaptation 'Cross-Fitting for Mendelian Randomization' (CFMR). We show that, even when using weak instruments, CFMR is, at worst, biased towards the null, which makes it a conservative one-sample MR approach. In particular, CFMR remains conservative even when the two samples used to perform the MR analysis completely overlap, whereas current state-of-the-art approaches (e.g., MR RAPS) display substantial bias in this setting. Another major advantage of CFMR lies in its use of all of the available data to select genetic instruments, which maximizes statistical power, as opposed to traditional two-sample MR where only part of the data is used to select the instrument. Consequently, CFMR is able to enhance statistical power in consortia-led meta-analyses by enabling a conservative one-sample MR to be performed in each cohort prior to a meta-analysis of the results across all the cohorts. In addition, CFMR enables a cross-ethnic MR analysis by accounting for ethnic heterogeneity, which is particularly important in meta-analyses where the participating cohorts may have different ethnicities. To our knowledge, none of the current MR approaches can account for such heterogeneity. Finally, CFMR enables the application of MR to exposures that are either rare or difficult to measure, which would normally preclude their analysis in the regular two-sample MR setting.
Weight gain after antiretroviral therapy initiation in people living with HIV in the United States: analyses of electronic medical records and prescription claims
Creators: name: Zhao, Xiaohui
name: Prajapati, Girish
name: Tse, Jenny
name: Near, Aimee M.
name: Kumar, Princy N.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Medicine
Pharmacology
Biotechnology
Environmental Sciences not elsewhere classified
Cancer
Computational Biology

description: Treatment guidelines recommend integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) regimens for treatment naïve people living with HIV (PLWH) in the United States (US). This retrospective database study compared weight changes following initiation of INSTI-, non-nucleoside reverse transcriptase inhibitor (NNRTI)-, or protease inhibitor (PI)-based ART in treatment-naïve PLWH. Adult (≥18 years) PLWH initiated on INSTI, NNRTI, or PI plus ≥2 nucleoside reverse transcriptase inhibitors (NRTI) between 1 January 2014 to 31 August 2019 were identified in IQVIA’s Ambulatory Electronic Medical Records (AEMR) linked to prescription drug claims (LRx). Weight changes over up to 36 months (M) of follow-up were compared among PLWH on INSTI- vs. NNRTI- and PI-based ART separately using non-linear mixed effect models, adjusting for demographics and baseline clinical characteristics. The INSTI, NNRTI, and PI cohorts included 931, 245, and 124 PLWH, respectively. For all three cohorts, the majority were male (78.2–81.2%) and overweight/obese (53.6–61.6%) at baseline; 40.8–45.2% of the groups were African American. The INSTI vs. NNRTI/PI cohorts were younger (median age: 38 years vs. 44 years/46 years), had lower weight at ART initiation (mean: 80.9 kg vs. 85.7 kg/85.0 kg), and had higher TAF usage during follow-up (55.6% vs. 24.1%/25.8%; all p < .05). Multivariate models showed higher weight gain among PLWH in INSTI vs. NNRTI and PI cohorts during treated follow-up (estimated weight gain after 36 M: 7.1 kg vs. 3.8 kg and 3.8 kg, both p < .05). Study findings highlight the need to monitor an increase in weight and potential metabolic complications among PLWH starting ART with INSTI.
Faster 0-1-Knapsack via Near-Convex Min-Plus-Convolution
Creators: name: Bringmann, Karl
name: Cassis, Alejandro
Publisher: name: arXiv
Year: 2023
Subjects: subject: Data Structures and Algorithms (cs.DS)
subject: FOS: Computer and information sciences

description: We revisit the classic 0-1-Knapsack problem, in which we are given $n$ items with their weights and profits as well as a weight budget $W$, and the goal is to find a subset of items of total weight at most $W$ that maximizes the total profit. We study pseudopolynomial-time algorithms parameterized by the largest profit of any item $p_{\max}$, and the largest weight of any item $w_{\max}$. Our main result are algorithms for 0-1-Knapsack running in time $\tilde{O}(n\,w_\max\,p_\max^{2/3})$ and $\tilde{O}(n\,p_\max\,w_\max^{2/3})$, improving upon an algorithm in time $O(n\,p_\max\,w_\max)$ by Pisinger [J. Algorithms '99]. In the regime $p_\max \approx w_\max \approx n$ (and $W \approx \mathrm{OPT} \approx n^2$) our algorithms are the first to break the cubic barrier $n^3$. To obtain our result, we give an efficient algorithm to compute the min-plus convolution of near-convex functions. More precisely, we say that a function $f \colon [n] \mapsto \mathbf{Z}$ is $Δ$-near convex with $Δ\geq 1$, if there is a convex function $\breve{f}$ such that $\breve{f}(i) \leq f(i) \leq \breve{f}(i) + Δ$ for every $i$. We design an algorithm computing the min-plus convolution of two $Δ$-near convex functions in time $\tilde{O}(nΔ)$. This tool can replace the usage of the prediction technique of Bateni, Hajiaghayi, Seddighin and Stein [STOC '18] in all applications we are aware of, and we believe it has wider applicability.
Calculation of elements of spin groups using generalized Pauli's theorem
Creators: name: Shirokov, D. S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: 15A66

description: We formulate generalizations of Pauli's theorem on the cases of real and complex Clifford algebras of even and odd dimensions. We give analogues of these theorems in matrix formalism. Using these theorems we present an algorithm for computing elements of spin groups that correspond to elements of orthogonal groups as double cover.
description: Advances in Applied Clifford Algebras, 2014 (to appear)
Efficient tensor-network simulation for the few-atom multimode Dicke model via coupling-matrix transformation
Creators: name: Ryu, Christopher J.
name: Na, Dong-Yeop
name: Chew, Weng C.
name: Kudeki, Erhan
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present a novel generalization of the chain mapping technique that applies to multi-atom, multimode systems by making use of coupling matrix transformations. This is extremely useful for tensor network simulations of multimode Dicke model and multi-spin-boson model because their coupling structures are altered from the star form to the chain form with near-neighbor interactions. Our approach produces an equivalent Hamiltonian with the latter coupling form, which we call the band Hamiltonian, and we demonstrate its equivalence to the multimode Dicke Hamiltonian. In the single atom case, our approach reduces to the chain mapping technique. When considering several tens of field modes, we have found that tensor network simulation of two atoms in the ultrastrong coupling regime is possible with our approach. We demonstrate this by considering a pair of entangled atoms confined in a cavity, interacting with thirty electromagnetic modes.
Understanding US healthcare provider preferences for consumption of publication content: opportunities to leverage omnichannel approaches
Creators: name: Bessler, Jessica B.
name: Fazzone, William
name: Sladicka, Nancy
name: Ruth, Adam
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Understanding the healthcare provider (HCP) journey of discovering and consuming medical and scientific information is critical for optimizing publication reach. A survey was conducted in 2019-2020 to understand how HCPs in the United States discover, review, and share publications of interest. A follow-up survey was conducted in 2021-2022 to assess how HCP behavior in the United States has evolved over the past 2 years, including due to the COVID-19 pandemic. Expanding on the survey completed in March 2020, a 24-question, online survey was conducted via SurveyMonkey. Survey invitations were sent via email list, social media, and personal outreach to practicing US-based HCPs with MD or DO degrees. Thirty-nine HCPs responded in 2020. Of the 33 HCPs who responded in 2021-2022, 67% were community practitioners; 45% had practiced for >20 years, while 30% had practiced for <5 years. Medical media channels (preferred by 73%) were the most common means of discovering publications of interest (vs targeted PubMed/Embase searches in early 2020). Sixty-seven percent of HCPs found supplemental digital information (also called publication enhancers) moderately/very useful for understanding article content vs 56% in the 2020 survey. When asked about pandemic-related behavior changes, HCPs reported increases in social media use (55%), medical media use (52%), direct reading of research articles (45%), accessing supplemental digital information (39%), and sharing/recommending articles to colleagues (33%). These survey results suggest that how HCPs interact with publication content is evolving and that these changes appear accelerated by the COVID-19 pandemic. This evolution is important to understand, and be accounted for, in the framework of omnichannel publication planning.
Teclistamab: First Approval
Creators: name: Kang, Connie
Publisher: name: Adis Journals
Year: 2022
Subjects: Medicine
Cancer

description: Declarations Funding The preparation of this review was not supported by any external funding. Authorship and Conflict of interest During the peer review process the manufacturer of the agent under review was offered an opportunity to comment on the article. Changes resulting from any comments received were made by the authors on the basis of scientific completeness and accuracy. Connie Kang is a salaried employee of Adis International Ltd/Springer Nature, and declares no relevant conflicts of interest. All authors contributed to the review and are responsible for the article content. Ethics approval, Consent to participate, Consent to publish, Availability of data and material, Code availability Not applicable.
 Additional information about this Adis Drug Review can be found here.
 Abstract Teclistamab (TECVAYLI®), a bispecific antibody that targets CD3 and B cell maturation antigen (BCMA), is being developed by Janssen Research and Development for the treatment of relapsed or refractory multiple myeloma. Teclistamab was recently granted conditional approval in the EU for the treatment of adult patients with relapsed and refractory multiple myeloma who have received three or more prior therapies (including an immunomodulatory agent, a proteasome inhibitor and an anti-CD38 antibody) and have demonstrated disease progression on the last therapy. This article summarizes the milestones in the development of teclistamab leading to this first approval for relapsed or refractory multiple myeloma.
 © Springer Nature Switzerland AG 2022
title: Παίζοντας με τον φανταστικό μου φίλο
titleType: AlternativeTitle
Creators: name: Κρεμμυδιώτου, Σοφία Π.
Publisher: name: University of Thessaly
Year: 2017
Subjects: subject: Φαντασία στα παιδιά
subject: Φανταστικοί συμπαίκτες
subject: Παιχνίδι

description: Σημείωση: διατίθεται συμπληρωματικό υλικό σε ξεχωριστό αρχείο.
L’equilibrio nei rapporti tra Corti europee e Corti nazionali: un’autentica quadratura del cerchio possibile solo in prospettiva de iure condendo
Creators: name: Ruggeri, Antonio
Publisher: name: Universita' degli Studi di Salerno
Year: 2021
Subjects: Relations between European and national courts
Interpretative techniques
Decision-making techniques
Changes in the rules on trials
The markedly political role of judges

description: The paper highlights the inconsistencies in theoretical construction exhibited both by the jurisprudential orientations of the European Courts and by those of the national courts in the field of safeguarding fundamental rights; in particular, it highlights the lack of an organic theory of the Charters on the part of the Constitutional Court. It therefore notes the unjustified difference in the treatment reserved to the charters themselves both in terms of the theory of sources and the theory of interpretation, as well as in terms of the decisional techniques used to resolve inconsistencies between the charters in question; and suggests certain changes to be made to the canons on which the proceedings are based, in order to remedy some of the drawbacks hitherto observed. The study concludes with a brief final remark concerning the overexposure of judges and their hyperpoliticisation.
Erasure conversion in a high-fidelity Rydberg quantum simulator
Creators: name: Scholl, Pascal
name: Shaw, Adam L.
name: Tsai, Richard Bing-Shiun
name: Finkelstein, Ran
name: Choi, Joonhee
name: Endres, Manuel
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: Minimizing and understanding errors is critical for quantum science, both in noisy intermediate scale quantum (NISQ) devices and for the quest towards fault-tolerant quantum computation. Rydberg arrays have emerged as a prominent platform in this context with impressive system sizes and proposals suggesting how error-correction thresholds could be significantly improved by detecting leakage errors with single-atom resolution, a form of erasure error conversion. However, two-qubit entanglement fidelities in Rydberg atom arrays have lagged behind competitors and this type of erasure conversion is yet to be realized for matter-based qubits in general. Here we demonstrate both erasure conversion and high-fidelity Bell state generation using a Rydberg quantum simulator. We implement erasure conversion via fast imaging of alkaline-earth atoms, which leaves atoms in a metastable state unperturbed and yields additional information independent of the final qubit readout. When excising data with observed erasure errors, we achieve a lower-bound for the Bell state generation fidelity of ${\geq} 0.9971^{+10}_{-13}$, which improves to ${\geq}0.9985^{+7}_{-12}$ when correcting for remaining state preparation errors. We further demonstrate erasure conversion in a quantum simulation experiment for quasi-adiabatic preparation of long-range order across a quantum phase transition, where we explicitly differentiate erasure conversion of preparation and Rydberg decay errors. We unveil the otherwise hidden impact of these errors on the simulation outcome by evaluating correlations between erasures and the final readout as well as between erasures themselves. Our work demonstrates the capability for Rydberg-based entanglement to reach fidelities in the ${\sim} 0.999$ regime, with higher fidelities a question of technical improvements, and shows how erasure conversion can be utilized in NISQ devices.
description: PS and ALS contributed equally to this work
Evolution of dust and molecular hydrogen in the Magellanic System
Creators: name: Yozin, Cameron
name: Bekki, Kenji
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We investigate the evolution of the interstellar medium (ISM) in self-consistent, chemodynamical simulations of the Magellanic Clouds (MCs) during their recent (z<0.3) past. An explicit modelling of dust and molecular hydrogen lifecycles enables the comparison of our models against the observed properties of the ISM, including elemental depletion from the gas-phase. Combining this model with a tidal-dominated paradigm for the formation for the Magellanic Stream and Bridge, we reproduce the age-metallicity relations, long gas depletion timescales, and presently observed dust and molecular hydrogen masses of the MCs to within their respective uncertainties. We find that these models' enrichment depends sensitively on the processing of dust within the ISM and the dynamical influence of external tides/stellar bars. The ratio of characteristic dust destruction timescales in our SMC and LMC models, a governing parameter of our models' evolution, is consistent with estimates based on observed supernova (SN) rates. Our reference MC models tend to exhibit the disputed universal dust-to-metal ratio, which we argue stems from the adoption of high SNe II condensation efficiencies. Our models are the first to reproduce the one-tenth solar metallicity of the Stream/Leading Arm following tidal stripping of the SMC; the hypothesis that the LMC contributes a metal-rich filament to the Stream, as implied by recent kinematic and abundance analyses, is also appraised in this study.
description: 28 pages, 25 figures, 3 tables; accepted for publication in MNRAS
Automated Alignment and On-Sky Performance of the Gemini Planet Imager Coronagraph
Creators: name: Savransky, Dmitry
name: Thomas, Sandrine J.
name: Poyneer, Lisa A.
name: Dunn, Jennifer
name: Macintosh, Bruce A.
name: Sadakuni, Naru
name: Dillon, Daren
name: Goodsell, Stephen J.
name: Hartung, Markus
name: Hibon, Pascale
name: Rantakyrö, Fredrik
name: Cardwell, Andrew
name: Serio, Andrew
name: team, with the GPI
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The Gemini Planet Imager (GPI) is a next-generation, facility instrument currently being commissioned at the Gemini South observatory. GPI combines an extreme adaptive optics system and integral field spectrograph (IFS) with an apodized-pupil Lyot coronagraph (APLC) producing an unprecedented capability for directly imaging and spectroscopically characterizing extrasolar planets. GPI's operating goal of $10^{-7}$ contrast requires very precise alignments between the various elements of the coronagraph (two pupil masks and one focal plane mask) and active control of the beam path throughout the instrument. Here, we describe the techniques used to automatically align GPI and maintain the alignment throughout the course of science observations. We discuss the particular challenges of maintaining precision alignments on a Cassegrain mounted instrument and strategies that we have developed that allow GPI to achieve high contrast even in poor seeing conditions.
description: 11 pages, 7 figures. Proceedings of the SPIE, 9147-151
Effect of random antiferromagnetic exchange on the spin waves in a three-dimensional Heisenberg ferromagnet
Creators: name: Hameed, S.
name: Wang, Z.
name: Gautreau, D. M.
name: Joe, J.
name: Olson, K. P.
name: Chi, S.
name: Gehring, P. M.
name: Hong, T.
name: Pajerowski, D. M.
name: Williams, T. J.
name: Xu, Z.
name: Matsuda, M.
name: Birol, T.
name: Fernandes, R. M.
name: Greven, M.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Neutron scattering is used to study spin waves in the three-dimensional Heisenberg ferromagnet YTiO$_3$, with spin-spin exchange disorder introduced $via$ La-substitution at the Y site. No significant changes are observed in the spin-wave dispersion up to a La concentration of 20%. However, a strong broadening of the spectrum is found, indicative of shortened spin-wave lifetimes. Density-functional theory calculations predict minimal changes in exchange constants as a result of average structural changes due to La substitution, in agreement with the data. The absence of significant changes in the spin-wave dispersion, the considerable lifetime effect, and the reduced ordered magnetic moment previously observed in the La-substituted system are qualitatively captured by an isotropic, nearest-neighbor, three-dimensional Heisenberg ferromagnet model with random antiferromagnetic exchange. We therefore establish Y$_{1-x}$La$_x$TiO$_3$ as a model system to study the effect of antiferromagnetic spin-exchange disorder in a three-dimensional Heisenberg ferromagnet.
description: 6 pages and 5 figures in main text. Supplementary material included
Weight gain following switch to integrase inhibitors from non-nucleoside reverse transcriptase or protease inhibitors in people living with HIV in the United States: analyses of electronic medical records and prescription claims
Creators: name: Tse, Jenny
name: Prajapati, Girish
name: Zhao, Xiaohui
name: Near, Aimee M.
name: Kumar, Princy N.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Real-world data evaluating weight changes in people living with HIV (PLWH) following switch to integrase strand transfer inhibitor (INSTI), specifically bictegravir (BIC), are limited. This retrospective cohort study analyzed weight changes upon switching to INSTI from non-nucleoside reverse transcriptase inhibitor (NNRTI) or protease inhibitor (PI) in treatment-experienced PLWH. Adult PLWH (≥18 years) treated with NNRTI or PI (non-switch cohorts) and those switching to INSTI (switch cohorts) between January 1, 2014 and August 31, 2019 were identified using IQVIA’s Ambulatory Electronic Medical Records linked to a prescription drug claims database. The associations of switching to INSTI and individual INSTI agents with having ≥5% weight gain at 12 months of follow-up were evaluated, adjusting for demographics and baseline clinical characteristics. At 12 months of follow-up, PLWH in the NNRTI–INSTI switch cohort (n = 508) were more likely to have ≥5% weight gain over 12 months compared to the NNRTI non-switch cohort (n = 614; odds ratio, OR [95% CI], 1.7 [1.2–2.4]). Switching from NNRTI to dolutegravir (DTG: OR [95% CI], 2.1 [1.4–3.0]) or BIC (2.0 [1.0–4.2]) resulted in significantly higher odds of ≥5% weight gain. PI–INSTI switch (n = 295) and non-switch (n = 228) cohorts had similar proportions of PLWH with ≥5% (21.1–23.4%) or ≥10% (7.8–7.9%) weight gain, and no significant association was found between switching from PI to INSTI and weight gain. Weight gain and related metabolic health of PLWH switching from NNRTI to DTG or BIC should be closely monitored by clinicians. Further research is needed to assess other metabolic outcomes in PLWH remaining on PI and those who switch from PI to INSTI.
A short note on the continuous Rokhlin property and the universal coefficient theorem
Creators: name: Szabo, Gabor
Publisher: name: arXiv
Year: 2014
Subjects: subject: Operator Algebras (math.OA)
subject: FOS: Mathematics
subject: 46L55, 19K35

description: Let $G$ be a metrizable compact group, $A$ a separable C*-algebra and $α$ a strongly continuous action of $G$ on $A$. Provided that $α$ satisfies the continuous Rokhlin property, we show that the property of satisfying the UCT in E-theory passes from $A$ to the crossed product C*-algebra $A\rtimes_αG$ and the fixed point algebra $A^α$. This extends a result by Gardella in the case that $G$ is the circle and $A$ is nuclear. For circle actions on separable, unital C*-algebras with the continuous Rokhlin property, we establish a connection between the $E$-theory equivalence class of the coefficient algebra $A$ and the fixed point algebra $A^α$.
description: 7 pages
Comparative outcomes associated with rivaroxaban versus warfarin use in elderly patients with atrial fibrillation or acute venous thromboembolism managed in the United States: a systematic review of observational studies
Creators: name: Baker, William L.
name: Roberts, Matthew S.
name: Bessada, Youssef
name: Caroti, Kimberly S.
name: Ashton, Veronica
name: Bookhart, Brahim K.
name: Coleman, Craig I.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Advancing age is a risk factor for developing non-valvular atrial fibrillation (NVAF) or acute venous thromboembolism (VTE). We assessed the comparative effectiveness, safety, costs, and healthcare utilization associated with rivaroxaban versus warfarin in patients of advanced age managed in the United States (US). We conducted a systematic review of Medline and Embase through April 2023 to identify real-world evidence (RWE) studies of older adults (at least 65+ years of age) with either NVAF or VTE who received either rivaroxaban or warfarin in the US and reported an outcome of stroke or systemic embolism (SSE), ischemic stroke (IS), recurrent VTE, major bleeding, intracranial hemorrhage, costs, or healthcare resource utilization. We classified each outcome of interest per study as “positive” (lower risk), “negative” (higher risk), or “neutral” based upon the summary effect size of rivaroxaban versus warfarin. Twenty-nine RWE studies met inclusion criteria, mostly (83%) in NVAF populations. For SSE with rivaroxaban versus warfarin, 68.8% of studies showed positive effects and 31.2% showed neutral outcome. For major bleeding, 57.7% showed neutral effects, 38.5% showed negative effects, and 3.8% of studies showed positive effects with rivaroxaban versus warfarin. Of the two studies reporting cost data, both were positive, showing lower costs for SSE for rivaroxaban versus warfarin and neutral cost for major bleeding costs. This systematic review supports findings from subgroup analyses of randomized controlled trials that, compared with warfarin, rivaroxaban is associated with generally neutral or positive effects on thrombosis and a mixed picture on bleeding outcomes in older adults with either NVAF or VTE treated in the United States.
Incompleteness Theorems for Observables in General Relativity
Creators: name: Panagiotopoulos, Aristotelis
name: Sparling, George
name: Christodoulou, Marios
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: Logic (math.LO)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 03E15 (Primary), 83C45 (Secondary)

description: The quest for complete observables in general relativity has been a longstanding open problem. We employ methods from descriptive set theory to show that no complete observable on rich enough collections of spacetimes is Borel definable. In fact, we show that it is consistent with the Zermelo-Fraenkel and Dependent Choice axioms that no complete observable for rich collections of spacetimes exists whatsoever. In a nutshell, this implies that the Problem of Observables is to 'analysis' what the Delian Problem was to 'straightedge and compass'. Our results remain true even after restricting the space of solutions to vacuum solutions. In other words, the issue can be traced to the presence of local degrees of freedom. We discuss the next steps in a research program that aims to further uncover this novel connection between theoretical physics and descriptive set theory.
description: 5 pages, 2 figures
Indian Ocean Arab Navigation Studies Towards a Global Perspective: Annotated Bibliography and Research Roadmap
Creators: name: Acevedo, Juan
name: Bénard, Inês
Publisher: name: figshare
Year: 2021
Subjects: subject: 220206 History and Philosophy of Science (incl. Non-historical Philosophy of Science)
subject: FOS: Philosophy, ethics and religion
subject: 90904 Navigation and Position Fixing
subject: FOS: Environmental engineering
subject: 40599 Oceanography not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 109999 Technology not elsewhere classified
subject: FOS: Other engineering and technologies
subject: 220203 History and Philosophy of Engineering and Technology
subject: 220299 History and Philosophy of Specific Fields not elsewhere classified
subject: 210310 Middle Eastern and African History
subject: FOS: History and archaeology

description: A detailed dossier on Indian Ocean Arabic nautical sources, with links to online repositories of primary sources and specific publications.
Tailoring the mechanical properties of 3D microstructures: a deep learning and genetic algorithm inverse optimization framework
Creators: name: Shang, Xiao
name: Liu, Zhiying
name: Zhang, Jiahui
name: Lyu, Tianyi
name: Zou, Yu
Publisher: name: arXiv
Year: 2023
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Materials-by-design has been historically challenging due to complex process-microstructure-property relations. Conventional analytical or simulation-based approaches suffer from low accuracy or long computational time and poor transferability, further limiting their applications in solving the inverse material design problem. Here, we establish a deep learning and genetic algorithm framework that integrates forward prediction and inverse exploration. This framework provides an end-to-end solution to achieve application-specific mechanical properties by microstructure optimization. In this study, we select the widely used Ti-6Al-4V to demonstrate the effectiveness of this framework by tailoring its microstructure and achieving various yield strength and elastic modulus across a large design space, while minimizing the stress concentration factor. Compared with conventional methods, our framework is efficient, versatile, and readily transferrable to other materials and properties. Paired with additive manufacturing's potential in controlling local microstructural features, our method has far-reaching potential for accelerating the development of application-specific, high-performing materials.
description: 19 pages, 5 figures
AnnotationGuidelines
Creators: name: SY Wong, Zoie
Publisher: name: figshare
Year: 2022
Subjects: subject: 80702 Health Informatics
subject: FOS: Media and communications
subject: Health Care

description: Annotation Guidelines for Incident Reports of Medication Errors (for English reports and for Japanese reports) MARCH 31, 2022 (V.1.0.2)
 Prepared by the ‘AI for Patient Safety’ team, led by Dr Zoie Wong at the Graduate School of Public Health, St. Luke’s International University.