cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A note on anti-coordination and social interactions
Creators: name: Cao, Zhigang
name: Yang, Xiaoguang
Publisher: name: arXiv
Year: 2012
Subjects: subject: Computer Science and Game Theory (cs.GT)
subject: Computational Complexity (cs.CC)
subject: Multiagent Systems (cs.MA)
subject: FOS: Computer and information sciences
subject: F.2.2
subject: 91-08

description: This note confirms a conjecture of [Bramoullé, Anti-coordination and social interactions, Games and Economic Behavior, 58, 2007: 30-49]. The problem, which we name the maximum independent cut problem, is a restricted version of the MAX-CUT problem, requiring one side of the cut to be an independent set. We show that the maximum independent cut problem does not admit any polynomial time algorithm with approximation ratio better than $n^{1-ε}$, where $n$ is the number of nodes, and $ε$ arbitrarily small, unless P=NP. For the rather special case where each node has a degree of at most four, the problem is still MAXSNP-hard.
description: 7 pages
Postural Tremor and Ataxia Progression in Spinocerebellar Ataxias
Creators: name: Gan, Shi-Rui
name: Wang, Jie
name: Figueroa, Karla P.
name: Pulst, Stefan M.
name: Tomishon, Darya
name: Lee, Danielle
name: Perlman, Susan
name: Wilmot, George
name: Gomez, Christopher M.
name: Schmahmann, Jeremy
name: Paulson, Henry
name: Shakkottai, Vikram G.
name: Ying, Sarah H.
name: Zesiewicz, Theresa
name: Bushara, Khalaf
name: Geschwind, Michael
name: Xia, Guangbin
name: Subramony, S. H.
name: Ashizawa, Tetsuo
name: Kuo, Sheng-Han
Publisher: name: Columbia University
Year: 2017
Subjects: subject: Ataxia
subject: Tremor
subject: Genetics
subject: FOS: Biological sciences
subject: Neurosciences
subject: FOS: Clinical medicine
subject: Neurology

description: Background: Postural tremor can sometimes occur in spinocerebellar ataxias (SCAs). However, the prevalence and clinical characteristics of postural tremor in SCAs are poorly understood, and whether SCA patients with postural tremor have different ataxia progression is not known.

Methods: We studied postural tremor in 315 patients with SCA1, 2, 3, and 6 recruited from the Clinical Research Consortium for Spinocerebellar Ataxias (CRC-SCA), which consists of 12 participating centers in the United States, and we evaluated ataxia progression in these patients from January 2010 to August 2012.

Results: Among 315 SCA patients, postural tremor was most common in SCA2 patients (SCA1, 5.8%; SCA2, 27.5%; SCA3, 12.4%; SCA6, 16.9%; p = 0.007). SCA3 patients with postural tremor had longer CAG repeat expansions than SCA3 patients without postural tremor (73.67 ± 3.12 vs. 70.42 ± 3.96, p = 0.003). Interestingly, SCA1 and SCA6 patients with postural tremor had a slower rate of ataxia progression (SCA1, β = –0.91, p < 0.001; SCA6, β = –1.28, p = 0.025), while SCA2 patients with postural tremor had a faster rate of ataxia progression (β = 1.54, p = 0.034). We also found that the presence of postural tremor in SCA2 patients could be influenced by repeat expansions of ATXN1 (β = –1.53, p = 0.037) and ATXN3 (β = 0.57, p = 0.018), whereas postural tremor in SCA3 was associated with repeat lengths in TBP (β = 0.63, p = 0.041) and PPP2R2B (β = –0.40, p = 0.032).

Discussion: Postural tremor could be a clinical feature of SCAs, and the presence of postural tremor could be associated with different rates of ataxia progression. Genetic interactions between ataxia genes might influence the brain circuitry and thus affect the clinical presentation of postural tremor.
title: Assessment of Empirical Relationships between Beach-Face Slope and Sediment Size Using Field Data (Burgas Bay Case)
Creators: name: Eftimova, Petya
name: Valchev, Nikolay
name: Prodanov, Bogdan
name: Andreeva, Nataliya
name: Lambev, Todor
name: Dimitrov, Liubomir
Publisher: name: Proceeding of 1st International Conference on Environmental Protection and Disaster RISKs, 2020, p. 405-419
Year: 2020
Subjects: subject: FOS: Earth and related environmental sciences

description: The study examines the relationships between the beach-face slopes and sediment sizes for several coastal stretches located in Burgas Bay using limited field data, and explores the applicability of a number of previously developed formulations for local geomorphic, lithologic and wave conditions. Knowledge on the clear dependence between considered parameters is of particular importance for many engineering applications such as calculation of maximum run-up, shoreline changes, beach berm erosion potential, and assessment of coastal flood and erosion hazards. The results have shown that none of the considered empirical relationships can be used straightforwardly, although some of them might be considered for future analysis. Hence, it is necessary to enrich the database with wider ranges of beachface slopes, sediment sizes coming from areas with different wave exposure and morphodynamics state in order to elaborate a reliable native relationship suitable for local to regional specifics of the western Black Sea coast. This underpins the importance of regular coastal monitoring.
description: Proceeding of 1st International Conference on Environmental Protection and Disaster RISKs, 2020, p. 405-419
Helicity dependent parton distributions
Creators: name: Scopetta, Sergio
name: Vento, Vicente
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The helicity dependent parton distributions describe the number density of partons with given longitudinal momentum x and given polarization in a hadron polarized longitudinally with respect to its motion. After the discovery, more than 70 years ago, that the proton is not elementary, the observation of Bjorken scaling in the late 1960s lead to the idea of hadrons containing almost pointlike constituents, the partons. Since then, Deep Inelastic Scattering (DIS) has played a crucial role in our understanding of hadron structure. Through DIS experiments it has been possible to link the partons to the quarks, and to unveil the presence of other pointlike constituents, the gluons, which lead into a dynamical theory of quarks and gluons - quantum chromodynamics (QCD). Polarized DIS, i.e. the collision of a longitudinally polarized lepton beam on a polarized target (either longitudinally or transversely polarized), provides a complementary information regarding the structure of the nucleon. Whereas ordinary DIS probes simply the number density of partons with a fraction x of the momentum of the parent hadron, polarized DIS can partly answer the question as to the number density of partons with given x and given spin polarization in a hadron of definite polarization, either parallel or transverse with respect to the motion of the hadron. In here, the phenomenology associated with DIS off longitudinally polarized targets, and the present theoretical understanding of the dynamics involved, are described.
description: 16 pages, 9 figures, invited Report for "Scholarpedia" (www.scholarpedia.org); revised version, reference added; matches the published version:http://www.scholarpedia.org/article/Longitudinal_polarization_functions
title: Dynamic invariance in the phonetic expression of syllable structure
title: a case study of Moroccan Arabic consonant clusters
titleType: Subtitle
Creators: name: Shaw, Jason A.
name: Gafos, Adamantios I.
name: Hoole, Philip
name: Zeroual, Chakir
Publisher: name: Universität Potsdam
Year: 2019

description: We asked whether invariant phonetic indices for syllable structure can be identified in a language where word-initial consonant clusters, regardless of their sonority profile, are claimed to be parsed heterosyllabically. Four speakers of Moroccan Arabic were recorded, using Electromagnetic Articulography. Pursuing previous work, we employed temporal diagnostics for syllable structure, consisting of static correspondences between any given phonological organisation and its presumed phonetic indices. We show that such correspondences offer only a partial understanding of the relation between syllabic organisation and continuous indices of that organisation. We analyse the failure of the diagnostics and put forth a new approach in which different phonological organisations prescribe different ways in which phonetic indices change as phonetic parameters are scaled. The main finding is that invariance is found in these patterns of change, rather than in static correspondences between phonological constructs and fixed values for their phonetic indices.
description: Postprints der Universität Potsdam : Humanwissenschaftliche Reihe, 516
Energy spectra of \textbf{2D} gravity and capillary waves with narrow frequency band excitation
Creators: name: Kartashova, Elena
Publisher: name: arXiv
Year: 2011
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Mathematical Physics (math-ph)
subject: Atmospheric and Oceanic Physics (physics.ao-ph)
subject: FOS: Physical sciences

description: In this Letter we present a new method, called chain equation method (CEM), for computing a cascade of distinct modes in a two-dimensional weakly nonlinear wave system generated by narrow frequency band excitation. The CEM is a means for computing the quantized energy spectrum as an explicit function of frequency $ø_0$ and stationary amplitude $A_0$ of excitation. The physical mechanism behind the generation of the quantized cascade is modulation instability. The CEM can be used in numerous \textbf{2D} weakly nonlinear wave systems with narrow frequency band excitation appearing in hydrodynamics, nonlinear optics, electrodynamics, convection theory etc. In this Letter the CEM is demonstrated with examples of gravity and capillary waves with dispersion functions $ø(k) \sim k^{1/2}$ and $ø(k) \sim k^{3/2}$ respectively, and for two different levels of nonlinearity $\eps=A_0k_0$: small ($\eps\sim 0.1$ to 0.25) and moderate ($\eps\sim 0.25$ to 0.4).
description: Submitted
Orofacial Involuntary Movements in Neurosyphilis: Beyond the Candy Sign
Creators: name: Lenka, Abhishek
name: Thota, Naveen
name: Stezin, Albert
name: Pal, Pramod Kumar
name: Yadav, Ravi
Publisher: name: Columbia University
Year: 2017
Subjects: subject: Neurosyphilis
subject: Face--Movement disorders
subject: Neurology
subject: Neurosciences
subject: FOS: Clinical medicine

description: Background: Involvement of the central nervous system in patients with syphilis (neurosyphilis) may result in several neuropsychiatric symptoms. Rarely, patients with neurosyphillis may develop movement disorders with different phenomenology. Subtle orofacial dyskinesias have been reported in patients with neurosyphilis, known as the candy sign.

Case Report: We describe a patient with neurosyphilis who presented with severe orofacial involuntary movements.

Discussion: Our patient had orofacial movements at presentation and severity of the movements was much higher than the candy sign that has been reported in patients with neurosyphilis. This report contributes towards the ever-expanding clinical spectrum of neurosyphilis.
Holographic fermions in d=2+1
Creators: name: Omid, Hamid
Publisher: name: University of British Columbia
Year: 2011

description: Recently, a large amount of effort has gone towards using the AdS/CFT conjecture in condensed matter physics. First, we present a review of the conjecture, then we use the conjecture to model 2+1-dimensional fermions. We find three kinds of solutions with different kinds of discrete symmetries. We show that Chern-Simons- like electric responses, computed using a holographic model appear with the right quantized coefficients.
Hyperon and nuclear symmetry energy in the neutron star
Creators: name: Ryu, Chung-Yeol
name: Hyun, Chang Ho
name: Lee, Chang-Hwan
Publisher: name: arXiv
Year: 2011
Subjects: subject: Nuclear Theory (nucl-th)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In this work, masses and radii of neutron stars are considered to investigate the effect of nuclear symmetry energy to the astrophysical observables. A relativistic mean field model with density-dependent meson-baryon coupling constants is employed in describing the equation of state of dense nuclear matter, and the density dependencies of the symmetry energies are quoted from the recent phenomenological formulae obtained from the heavy ion data at subnuclear saturation densities. Since hyperons can take part in the $β$-equilibrium of the dense matter inside neutron stars, we include hyperons in our estimation and their roles are discussed in combination with that of the nuclear symmetry energy.
description: 17 pages, 5 figures, to be published in Physical Review C
Caveolin1 Is Required for Th1 Cell Infiltration, but Not Tight Junction Remodeling, at the Blood-Brain Barrier in Autoimmune Neuroinflammation
Creators: name: Lutz, Sarah E.
name: Smith, Julian R.
name: Kim, Dae Hwan
name: Olson, Carl V. L.
name: Ellefsen, Kyle
name: Bates, Jennifer M.
name: Gandhi, Sunil P.
name: Agalliu, Dritan
Publisher: name: Columbia University
Year: 2017
Subjects: Multiple sclerosis
Autoimmune diseases
Blood-brain barrier disorders
Tight junctions (Cell biology)
Neurology

description: Lymphocytes cross vascular boundaries via either disrupted tight junctions (TJs) or caveolae to induce tissue inflammation. In the CNS, Th17 lymphocytes cross the blood-brain barrier (BBB) before Th1 cells; yet this differential crossing is poorly understood. We have used intravital two-photon imaging of the spinal cord in wild-type and caveolae-deficient mice with fluorescently labeled endothelial tight junctions to determine how tight junction remodeling and caveolae regulate CNS entry of lymphocytes during the experimental autoimmune encephalomyelitis (EAE) model for multiple sclerosis. We find that dynamic tight junction remodeling occurs early in EAE but does not depend upon caveolar transport. Moreover, Th1, but not Th17, lymphocytes are significantly reduced in the inflamed CNS of mice lacking caveolae. Therefore, tight junction remodeling facilitates Th17 migration across the BBB, whereas caveolae promote Th1 entry into the CNS. Moreover, therapies that target both tight junction degradation and caveolar transcytosis may limit lymphocyte infiltration during inflammation.
Embankment overtopping protection by riprap considering interstitial flow
Creators: name: Wahl, Tony L.
name: Colorado State University. Department Of Engineering, Publisher
Publisher: name: Mountain Scholar
Year: 2016
Subjects: riprap design
interstitial flow
critical shear stress

description: Presented at the Protections 2016: 2nd international seminar on dam protection against overtopping: concrete dams, embankment dams, levees, tailings dams held on 7th-9th September, 2016, at Colorado State University in Fort Collins, Colorado, USA. The increasing demand for dam and levee safety and flood protection has motivated new research and advancements and a greater need for cost-effective measures in overtopping protection as a solution for overtopping concerns at levees and dams. This seminar will bring together leading experts from practice, research, development, and implementation for two days of knowledge exchange followed by a technical tour of the Colorado State University Hydraulic Laboratory with overtopping flume and wave simulator. This seminar will focus on: Critical issues related to levees and dams; New developments and advanced tools; Overtopping protection systems; System design and performance; Applications and innovative solutions; Case histories of overtopping events; Physical modeling techniques and recent studies; and Numerical modeling methods.
description: Includes bibliographical references.
description: Riprap is commonly provided to protect embankment slopes from localized erosion caused by surface runoff during rainfall events, but it can also provide erosion protection during small overtopping events. When flow rates are small, most water may flow interstitially through the riprap layer, then gradually above the riprap layer as flow rates increase. On relatively steep slopes, interstitial flow may still be a significant proportion of the total flow—even 100% of the flow—when the failure discharge is reached. In the late 1990s the Bureau of Reclamation sponsored tests on 2H:1V (50%) embankment slopes to determine allowable rates of overtopping flow for large riprap with median stone sizes up to 26-inch diameter. These tests included measurements of interstitial flow, and Mishra (1998) and Frizell et al. (1998) used the collected data to develop a design procedure for riprap on steep slopes accounting for interstitial flow. Unlike other riprap design equations that relate allowable discharge or stone size to independent variables through simple closed-form equations, the method incorporates interstitial flow in a mechanistic way through iterative calculations that add complexity to the solution process. This paper illustrates the Mishra/Frizell design method through example calculations and highlights key aspects of the solution process. Important conclusions are drawn related to the use of riprap for overtopping flow protection on typical embankment dam slopes.
Transport of non-aqueous nano-dispersed catalyst suspensions in porous media
Creators: name: Zamani, Amir
Publisher: name: University of Calgary
Year: 2010

description: Bibliography: p. 172-177
description: Many pages are in colour.
description: Vast heavy oil and bitumen resources and the current environmental challenges associated with their exploitation beckon new ideas for improved production technology. One promising new idea is the proposed in-situ upgrading of heavy oil during thermal recovery by catalytic hydrogenation using nanometer size dispersed catalysts. This requires placement of the ultra-dispersed catalysts deep into the formation where it can accelerate the high temperature upgrading reactions. This dissertation presents the results of several experiments that were carried out to systematically examine the propagation of nano-dispersed catalyst suspensions in sand packs at simulated reservoir conditions. These experiments involved injection of nano-size catalyst particles suspended in oil into a sand pack. The concentration and size distribution of the particles injected at the inlet and produced at the production end were measured. The pressure drops in different segments along length of the sand pack were monitored continuously. The retention behavior of particles in the sand was examined by measuring the catalyst concentration in the bed as a function of the distance from the injection end. Propagation of ultra-dispersed catalysts suspended in oil with and without commercial surfactant through the sand beds was examined. Effects of several parameters, including connate water salinity, absolute permeability, system temperature, and particle concentration were also evaluated. At the end, the propagation behavior of ultra-dispersed catalyst particles in Athabasca reservoir sand was examined at two different flow rates. The results show that it is possible to propagate the ultra-dispersed catalyst suspensions through sand beds. However, the catalydt particle deposit along the sand pack in a way that much higher retention occurs in the entrance region of the bed. Particles appear to be deposited on sand surface by an attachment mechanism deep inside the bed but larger particle appear to be trained by mechanical trapping near the inlet face. The deposition of particles was found to be almost irreversible. A phenomenological approach was used to model the macroscopic propagation behavior of suspended particles in the porous medium. The model was used to history match the effluent composition profile observed in the experiments and the deposition profile obtained from post-mortem analysis.
Multi-objective optimal designs in comparative clinical trials with covariates: The reinforced doubly adaptive biased coin design
Creators: name: Antognini, Alessandro Baldi
name: Zagoraiou, Maroussa
Publisher: name: arXiv
Year: 2012
Subjects: subject: Methodology (stat.ME)
subject: Statistics Theory (math.ST)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: The present paper deals with the problem of allocating patients to two competing treatments in the presence of covariates or prognostic factors in order to achieve a good trade-off among ethical concerns, inferential precision and randomness in the treatment allocations. In particular we suggest a multipurpose design methodology that combines efficiency and ethical gain when the linear homoscedastic model with both treatment/covariate interactions and interactions among covariates is adopted. The ensuing compound optimal allocations of the treatments depend on the covariates and their distribution on the population of interest, as well as on the unknown parameters of the model. Therefore, we introduce the reinforced doubly adaptive biased coin design, namely a general class of covariate-adjusted response-adaptive procedures that includes both continuous and discontinuous randomization functions, aimed to target any desired allocation proportion. The properties of this proposal are described both theoretically and through simulations.
description: Published in at http://dx.doi.org/10.1214/12-AOS1007 the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Speech–Language Pathology Evaluation and Management of Hyperkinetic Disorders Affecting Speech and Swallowing Function
Creators: name: Barkmeier-Kraemer, Julie M.
name: Clark, Heather M.
Publisher: name: Columbia University
Year: 2017
Subjects: Speech disorders
Dystonia
Movement disorders--Treatment
Chorea
Myoclonus
Neurology

description: Background: Hyperkinetic dysarthria is characterized by abnormal involuntary movements affecting respiratory, phonatory, and articulatory structures impacting speech and deglutition. Speech–language pathologists (SLPs) play an important role in the evaluation and management of dysarthria and dysphagia. This review describes the standard clinical evaluation and treatment approaches by SLPs for addressing impaired speech and deglutition in specific hyperkinetic dysarthria populations.

Methods: A literature review was conducted using the data sources of PubMed, Cochrane Library, and Google Scholar. Search terms included 1) hyperkinetic dysarthria, essential voice tremor, voice tremor, vocal tremor, spasmodic dysphonia, spastic dysphonia, oromandibular dystonia, Meige syndrome, orofacial, cervical dystonia, dystonia, dyskinesia, chorea, Huntington’s Disease, myoclonus; and evaluation/treatment terms: 2) Speech–Language Pathology, Speech Pathology, Evaluation, Assessment, Dysphagia, Swallowing, Treatment, Management, and diagnosis.

Results: The standard SLP clinical speech and swallowing evaluation of chorea/Huntington’s disease, myoclonus, focal and segmental dystonia, and essential vocal tremor typically includes 1) case history; 2) examination of the tone, symmetry, and sensorimotor function of the speech structures during non-speech, speech and swallowing relevant activities (i.e., cranial nerve assessment); 3) evaluation of speech characteristics; and 4) patient self-report of the impact of their disorder on activities of daily living. SLP management of individuals with hyperkinetic dysarthria includes behavioral and compensatory strategies for addressing compromised speech and intelligibility. Swallowing disorders are managed based on individual symptoms and the underlying pathophysiology determined during evaluation.

Discussion: SLPs play an important role in contributing to the differential diagnosis and management of impaired speech and deglutition associated with hyperkinetic disorders.
Additional file 1 of Effect of e-health interventions on HIV prevention: a protocol of systematic review and meta-analysis
Creators: name: Wang, Lei
name: Yan, Xiang-yu
name: Mei, Lin
name: Jia, Zhong-wei
name: Hao, Rui-gang
name: Xu, Ji-hong
name: Zhang, Bo
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1. PRISMA-P 2015 Checklist.
Development of Hyperkinesias after Long-term Pallidal Stimulation for Idiopathic Segmental Dystonia
Creators: name: Wloch, Andreas
name: Blahak, Christian
name: Abdallat, Mahmoud
name: Heissler, Hans E.
name: Wolf, Marc E.
name: Krauss, Joachim K.
Publisher: name: Columbia University
Year: 2017
Subjects: Globus pallidus
Brain stimulation--Therapeutic use
Dystonia
Hyperkinesia
Neurology

description: Background: Chronic deep brain stimulation (DBS) of the globus pallidus internus (GPi) has become an established treatment for dystonia. While bradykinetic symptoms may occur on chronic stimulation, the appearance of hyperkinetic movements has not been well characterized.

Case Report: We report on the development of hyperkinesias after more than 10 years of GPi DBS.

Discussion: Hyperkinesias may evolve upon long-term GPi DBS in dystonia. This might be related to a combined effect consisting of a reduced threshold for effective GPi stimulation for dystonia and spread of current to the globus pallidus externus.
Chaotic diffusion of the Vesta family induced by close encounters with massive asteroids
Creators: name: Delisle, J. -B.
name: Laskar, J.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We numerically estimate the semi-major axis chaotic diffusion of the Vesta family asteroids induced by close encounters with 11 massive main belt asteroids : (1) Ceres, (2) Pallas, (3) Juno, (4) Vesta, (7) Iris, (10) Hygiea, (15) Eunomia, (19) Fortuna, (324) Bamberga, (532) Herculina, (704) Interamnia. We find that most of the diffusion is due to Ceres and Vesta. By extrapolating our results, we are able to constrain the global effect of close encounters with all the main belt asteroids. A comparison of this drift estimate with the one expected for the Yarkovsky effect shows that for asteroids whose diameter is larger than about 40 km, close encounters dominate the Yarkovsky effect. Overall, our findings confirm the standard scenario for the history of the Vesta family.
description: 9 pages, 9 figures, 1 Table, submitted
Huntington Disease: The Complexities of Making and Disclosing a Clinical Diagnosis After Premanifest Genetic Testing
Creators: name: McCusker, Elizabeth
name: Loy, Clement T.
Publisher: name: Columbia University
Year: 2017
Subjects: Huntington's disease
Medical ethics
Genetic disorders--Diagnosis
Cognition disorders

description: The management of patients and families affected by Huntington disease (HD) is complicated by several factors, both practical and ethical. It can be difficult to determine the onset of clinically manifest HD (mHD). In addition, it can be challenging to decide when to disclose the diagnosis to the affected individual. Firstly, the features of HD, an incurable, inherited, neurocognitive disorder that often manifests in young adulthood, influence how the person presents and accepts a diagnosis. Secondly, a positive genetic test for HD may result in a genetic diagnosis, sometimes years before the development of clinical features and the diagnosis of mHD. Thirdly, observational studies of unaffected gene expansion carriers documented HD manifestations up to 10 years before the typical presentation for diagnosis. These developments may permit earlier genetic diagnosis and information regarding the patient’s likely status with respect to the development of clinical disease. Making the genetic diagnosis of HD and providing information regarding disease status, earlier rather than later, respects the person’s right to know and preserves honesty in the doctor/patient relationship. Conversely, delaying the diagnosis respects the right not to know, avoids potential discrimination, and permits the person to live a “normal” life for longer, in the context of a disease without cure. This discussion has implications for other inherited and neurocognitive disorders.
Recent Updates on Acquired Hepatocerebral Degeneration
Creators: name: Shin, Hae-Won
name: Park, Hee Kyung
Publisher: name: Columbia University
Year: 2017
Subjects: Liver--Cirrhosis
Neurology
Movement disorders

description: Background: Acquired hepatocerebral degeneration (AHD) refers to a chronic neurological syndrome in patients with advanced hepatobiliary diseases. This comprehensive review focuses on the pathomechanism and neuroimaging findings in AHD.

Methods: A PubMed search was performed using the terms “acquired hepatocerebral degeneration,” “chronic hepatocerebral degeneration,” “Non-Wilsonian hepatocerebral degeneration,” “cirrhosis-related parkinsonism,” and “manganese and liver disease.”

Results: Multiple mechanisms involving the accumulation of toxic substances such as ammonia or manganese and neuroinflammation may lead to widespread neurodegeneration in AHD. Clinical characteristics include movement disorders, mainly parkinsonism and ataxia-plus syndrome, as well as cognitive impairment with psychiatric features. Neuroimaging studies of AHD with parkinsonism show hyperintensity in the bilateral globus pallidus on T1-weighted magnetic resonance images, whereas molecular imaging of the presynaptic dopaminergic system shows variable findings. Ataxia-plus syndrome in AHD may demonstrate high-signal lesions in the middle cerebellar peduncles on T2-weighted images.

Discussion: Future studies are needed to elucidate the exact pathomechanism and neuroimaging findings of this heterogeneous syndrome.
title: Genetic differences in the serum proteome of horses, donkeys and mules are detectable by protein profiling
Creators: name: Henze, Andrea
name: Aumer, Franziska
name: Grabner, Arthur
name: Raila, Jens
name: Schweigert, Florian J.
Publisher: name: Universität Potsdam
Year: 2019

description: Although horses and donkeys belong to the same genus, their genetic characteristics probably result in specific proteomes and post-translational modifications (PTM) of proteins. Since PTM can alter protein properties, specific PTM may contribute to species-specific characteristics. Therefore, the aim of the present study was to analyse differences in serum protein profiles of horses and donkeys as well as mules, which combine the genetic backgrounds of both species. Additionally, changes in PTM of the protein transthyretin (TTR) were analysed. Serum protein profiles of each species (five animals per species) were determined using strong anion exchanger ProteinChips (R) (Bio-Rad, Munich, Germany) in combination with surface-enhanced laser desorption ionisation-time of flight MS. The PTM of TTR were analysed subsequently by immunoprecipitation in combination with matrix-assisted laser desorption ionisation-time of flight MS. Protein profiling revealed species-specific differences in the proteome, with some protein peaks present in all three species as well as protein peaks that were unique for donkeys and mules, horses and mules or for horses alone. The molecular weight of TTR of horses and donkeys differed by 30Da, and both species revealed several modified forms of TTR besides the native form. The mass spectra of mules represented a merging of TTR spectra of horses and donkeys. In summary, the present study indicated that there are substantial differences in the proteome of horses and donkeys. Additionally, the results probably indicate that the proteome of mules reveal a higher similarity to donkeys than to horses.
description: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe, 567
Quantum criticality in Kondo quantum dot coupled to helical edge states of interacting 2D topological insulators
Creators: name: Chung, Chung-Hou
name: Silotri, Salman
Publisher: name: arXiv
Year: 2012
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We investigate theoretically the quantum phase transition (QPT) between the one-channel Kondo (1CK) and two-channel Kondo (2CK) fixed points in a quantum dot coupled to helical edge states of interacting 2D topological insulators (2DTI) with Luttinger parameter $01 that the 2CK fixed point can be unstable towards the 1CK fixed point and the system may undergo a quantum phase transition between 1CK and 2CK fixed points. The QPT in our model comes as a result of the combined Kondo and the helical Luttinger physics in 2DTI, and it serves as the first example of the 1CK-2CK QPT that is accessible by the controlled RG approach. We extract quantum critical and crossover behaviors from various thermodynamical quantities near the transition. Our results are robust against particle-hole asymmetry for 1/2
description: 17 pages, 9 figures, more details added, typos corrected, revised Sec. IV, V, Appendix A and B
A Case of Beta-propeller Protein-associated Neurodegeneration due to a Heterozygous Deletion of WDR45
Creators: name: Hermann, Andreas
name: Kitzler, Hagen H.
name: Pollack, Tobias
name: Biskup, Saskia
name: Kruger, Stefanie
name: Funke, Claudia
name: Terrile, Caterina
name: Haack, Tobias B.
Publisher: name: Columbia University
Year: 2017
Subjects: Nervous system--Degeneration
Genes
Neurology
Proteins

description: Background: Static encephalopathy of childhood with neurodegeneration in adulthood is a phenotypically distinctive, X-linked dominant subtype of neurodegeneration with brain iron accumulation (NBIA). WDR45 mutations were recently identified as causal. WDR45 encodes a beta-propeller scaffold protein with a putative role in autophagy, and the disease has been renamed beta-propeller protein-associated neurodegeneration (BPAN).

Case Report: Here we describe a female patient suffering from a classical BPAN phenotype due to a novel heterozygous deletion of WDR45. An initial gene panel and Sanger sequencing approach failed to uncover the molecular defect. Based on the typical clinical and neuroimaging phenotype, quantitative polymerase chain reaction of the WDR45 coding regions was undertaken, and this showed a reduction of the gene dosage by 50% compared with controls.

Discussion: An extended search for deletions should be performed in apparently WDR45-negative cases presenting with features of NBIA and should also be considered in young patients with predominant intellectual disabilities and hypertonia/parkinsonism/dystonia.
Justification of the two-bulge method in the theory of bodily tides
Creators: name: Efroimsky, Michael
Publisher: name: arXiv
Year: 2012
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Geophysics (physics.geo-ph)
subject: FOS: Physical sciences

description: Mathematical modeling of bodily tides can be carried out in various ways. Most straightforward is the method of complex amplitudes, which is often used in the planetary science. Another method, employed both in planetary science and astrophysics, is based on decomposition of each harmonic of the tide into two bulges oriented orthogonally to one another. We prove that the two methods are equivalent. Specifically, we demonstrate that the two-bulge method is not a separate approximation, but ensues directly from the Fourier expansion of a linear tidal theory equipped with an arbitrary rheological model involving a departure from elasticity. To this end, we use the most general mathematical formalism applicable to linear bodily tides. To express the tidal amendment to the potential of the perturbed primary, we act on the tide-raising potential of the perturbing secondary with a convolution operator. This enables us to interconnect a complex Fourier component of the tidally generated potential of the perturbed primary with the appropriate complex Fourier component of the tide-raising potential of the secondary. Then we demonstrate how this interrelation entails the two-bulge description. While less economical mathematically, the two-bulge approach has a good illustrative power, and may be employed on a par with a more concise method of complex amplitudes. At the same time, there exist situations where the two-bulge method becomes more practical for technical calculations.
description: Astronomy & Astrophysics, in press
RISER: The first All- European RISC-V Cloud Server Infrastructure
Creators: name: Marazakis, Manolis
name: Louloudakis, Stelios
Publisher: name: Zenodo
Year: 2023

description: Public announcement of the RISER ('RISC-V for Cloud Services') project, in ERCIM News, issue Nr. 133 (April 2023).
Generalized method of moments : theoretical, econometric and simulation studies
Creators: name: Liang, Yitian
Publisher: name: University of British Columbia
Year: 2011

description: The GMM estimator is widely used in the econometrics literature. This thesis mainly focus on three aspects of the GMM technique. First, I derive the prooves to study the asymptotic properties of the GMM estimator under certain conditions. To my best knowledge, the original complete prooves proposed by Hansen (1982) is not easily available. In this thesis, I provide complete prooves of consistency and asymptotic normality of the GMM estimator under some stronger assumptions than those in Hansen (1982). Second, I illustrate the application of GMM estimator in linear models. Specifically, I emphasize the economic reasons underneath the linear statistical models where GMM estimator (also referred to the Instrumental Variable estimator) is widely used. Third, I perform several simulation studies to investigate the performance of GMM estimator under different situations.
Blue water dragon: China's ascent to maritime power
Creators: name: Stone, Simon E.
Publisher: name: University of Calgary
Year: 2010

description: Bibliography: p. 105-110
description: China is developing a modem, advanced blue water navy capable of projecting power over the horizon and across oceans. Building on a foundation of unique strategic heritage and military history, China is in the midst of a significant shift in strategy. Determined to retain its historical position of primacy in the region, and bolstered by a burgeoning economy, China's navy is the leading edge of a modem reformation. Beijing requires a fleet capable of protecting far-flung lines of communication and shipping lanes that deliver sustained economic growth. As such, the People's Liberation Army Navy (PLAN) is undertaking a dramatic modernization accompanied by a bold new strategic vision - the PLAN as a blue water navy.
title: British Policy Towards Cultural Relations with South Africa, 1960 to 1994
Creators: name: Feather, D
Publisher: name: Liverpool John Moores University
Year: 2022

description: This thesis analyses British policy towards cultural relations with South Africa in the period 1960 to 1994. These aspects of UK-South African relations have gained little scholarly attention, this thesis aims to rectify this, and demonstrate that these policies worked alongside more traditional diplomatic and economic links as a means of protecting Britain’s important interests in the country. British policy is analysed through three main themes, educational links, the exploitation of ‘cultural manifestations’, and sporting contact. However, as South Africa’s racialist Apartheid policies increasingly became an outlier in the post-colonial era, the British government’s (HMG) ability to utilise cultural connections became more difficult as African, Asian, and Caribbean Commonwealth members tried to isolate Pretoria, particularly through the sports boycott. This thesis highlights how HMG attempted to navigate its cultural policy options toward South Africa under these difficult circumstances, demonstrating the importance of the country in the minds of much of the UK’s political and administrative elite, even after its exit from the Commonwealth in 1961. British global power declined significantly in this period, and much of the academic literature suggests that Britain looked increasingly to Europe rather than its former imperial possessions. However, as this thesis demonstrates, officials clearly viewed South Africa as part of Britain’s ‘sphere of influence’, and were wary of attempts by both France and the United States to utilise sport or academic scholarships in order to enhance their own relationships with the Republic. Clearly, despite decolonisation, and South Africa’s exit from the Commonwealth, HMG still approached southern Africa with an imperial mind-set.
Speeding up Cylindrical Algebraic Decomposition by Gröbner Bases
Creators: name: Wilson, David J.
name: Bradford, Russell J.
name: Davenport, James H.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Symbolic Computation (cs.SC)
subject: Algebraic Geometry (math.AG)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics
subject: G.4
subject: 68W30

description: Gröbner Bases and Cylindrical Algebraic Decomposition are generally thought of as two, rather different, methods of looking at systems of equations and, in the case of Cylindrical Algebraic Decomposition, inequalities. However, even for a mixed system of equalities and inequalities, it is possible to apply Gröbner bases to the (conjoined) equalities before invoking CAD. We see that this is, quite often but not always, a beneficial preconditioning of the CAD problem. It is also possible to precondition the (conjoined) inequalities with respect to the equalities, and this can also be useful in many cases.
description: To appear in Proc. CICM 2012, LNCS 7362
Characterizing Orthostatic Tremor Using a Smartphone Application
Creators: name: Balachandar, Arjun
name: Fasano, Alfonso
Publisher: name: Columbia University
Year: 2017
Subjects: Tremor
Movement disorders--Diagnosis
Medical technology
Smartphones
Accelerometers

description: Background: Orthostatic tremor is one of the few tremor conditions requiring an electromyogram for definitive diagnosis since leg tremor might not be visible to the naked eye.

Phenomenology Shown: An iOS application (iSeismometer, ObjectGraph LLC, New York) using an Apple iPhone 5 (Cupertino, CA, USA) inserted into the patient’s sock detected a tremor with a frequency of 16.4 Hz on both legs.

Educational Value: The rapid and straightforward accelerometer-based recordings accomplished in this patient demonstrate the ease with which quantitative analysis of orthostatic tremor can be conducted and, importantly, demonstrates the potential application of this approach in the assessment of any lower limb tremor.
title: How much is too much?
title: a case report of nutritional supplement use of a high-performance athlete
titleType: Subtitle
Creators: name: Carlsohn, Anja
name: Cassel, Michael
name: Linné, Karsten
name: Mayer, Frank
Publisher: name: Universität Potsdam
Year: 2019

description: Although dietary nutrient intake is often adequate, nutritional supplement use is common among elite athletes. However, high-dose supplements or the use of multiple supplements may exceed the recommended daily allowance (RDA) of particular nutrients or even result in a daily intake above tolerable upper limits (UL). The present case report presents nutritional intake data and supplement use of a highly trained male swimmer competing at international level. Habitual energy and micronutrient intake were analysed by 3 d dietary reports. Supplement use and dosage were assessed, and total amount of nutrient supply was calculated. Micronutrient intake was evaluated based on RDA and UL as presented by the European Scientific Committee on Food, and maximum permitted levels in supplements (MPL) are given. The athlete’s diet provided adequate micronutrient content well above RDA except for vitamin D. Simultaneous use of ten different supplements was reported, resulting in excess intake above tolerable UL for folate, vitamin E and Zn. Additionally, daily supplement dosage was considerably above MPL for nine micronutrients consumed as artificial products. Risks and possible side effects of exceeding UL by the athlete are discussed. Athletes with high energy intake may be at risk of exceeding UL of particular nutrients if multiple supplements are added. Therefore, dietary counselling of athletes should include assessment of habitual diet and nutritional supplement intake. Educating athletes to balance their diets instead of taking supplements might be prudent to prevent health risks
that may occur with long-term excess nutrient intake.
description: Postprints der Universität Potsdam : Humanwissenschaftliche Reihe, 515
Additional file 2 of Effect of e-health interventions on HIV prevention: a protocol of systematic review and meta-analysis
Creators: name: Wang, Lei
name: Yan, Xiang-yu
name: Mei, Lin
name: Jia, Zhong-wei
name: Hao, Rui-gang
name: Xu, Ji-hong
name: Zhang, Bo
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 2. Search strategy.
title: Petrogenesis and tectonic evolution of metaluminous sub-alkaline granitoids from the Takab Complex, NW Iran
Creators: name: Hajialioghli, Robab
name: Moazzen, Mohssen
name: Jahangiri, Ahmad
name: Oberhänsli, Roland
name: Mocek, Beate
name: Altenberger, Uwe
Publisher: name: Universität Potsdam
Year: 2019

description: The Takab complex is composed of a variety of metamorphic rocks including amphibolites, metapelites, mafic granulites, migmatites and meta-ultramafics, which are intruded by the granitoid. The granitoid magmatic activity occurred in relation to the subduction of the Neo-Tethys oceanic crust beneath the Iranian crust during Tertiary times. The granitoids are mainly granodiorite, quartz monzodiorite, monzonite and quartz diorite. Chemically, the magmatic rocks are characterized by ASI < 1.04, AI < 0.87 and high contents of CaO (up to ∼ 14.5 wt %), which are consistent with the I-type magmatic series. Low FeO t /(FeO t +MgO) values (< 0.75) as well as low Nb, Y and K 2 O contents of the investigated rocks resemble the calc-alkaline series. Low SiO 2 , K 2 O/Na 2 O and Al 2 O 3 accompanied by high CaO and FeO contents indicate melting of metabasites as an appropriate source for the intrusions. Negative Ti and Nb anomalies verify a metaluminous crustal origin for the protoliths of the investigated igneous rocks. These are comparable with compositions of the associated mafic migmatites, in the Takab metamorphic complex, which originated from the partial melting of amphibolites. Therefore, crustal melting and a collision-related origin for the Takab calc-alkaline intrusions are proposed here on the basis of mineralogy and geochemical characteristics. The P–T evolution during magmatic crystallization and subsolidus cooling stages is determined by the study of mineral chemistry of the granodiorite and the quartz diorite. Magmatic crystallization pressure and temperature for the quartz-diorite and the granodiorite are estimated to be P ∼ 7.8 ± 2.5 kbar, T ∼ 760 ± 75 ◦C and P ∼ 5 ± 1 kbar, T ∼ 700 ◦C, respectively. Subsolidus conditions are consistent with temperatures of ∼ 620 ◦C and ∼ 600 ◦C, and pressures of ∼ 5 kbar and ∼ 3.5 kbar for the quartz-diorite and the granodiorite, respectively.
description: Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe, 570