cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Central immunological position of the human blood group O  and phenotype-determining enzymes in growth and infectious disease.
Creators: name: Arend, Peter
Publisher: name: Figshare
Year: 2017
Subjects: Cancer

description: Development of the blood group A
phenotype is associated with the impaired formation of adaptive and innate
immunoglobulins due to clonal selection and phenotypic, glycosidic accommodation
of plasma proteins. Compared with individuals from blood group O(H),
individuals with blood group A have a significantly higher risk of developing
certain types of cancer and exhibit strong susceptibility to malaria tropica or
infection by Plasmodium falciparum. Although
malaria tertiana, caused by Plasmodium vivax, is the best-documented type of malaria, P. falciparum causes the most severe
disease. In both malaria types, the risk of developing disease is molecularly
strongly related to blood group phenotype formation, although outcomes are
reverse; while the Duffy positive (Fya) individuals
are most susceptible to P. vivax
infections but the Duffy antigen receptor
for chemokines (DARC) protein exerts marked cancer regulation, human blood
group A shows significant susceptibility to both life-threatening infection by P. falciparum and distinct types of cancer.
Aside from the molecular features of the DARC protein, the phenotype-determining
glycotransferase(s) from blood group A, affecting the levels of anti-A/Tn
cross-reactive immunoglobulins, might also explain the entry of Plasmodium merozoites into the host's red
blood cells (RBCs) via the parasite's serine repeat antigen (SERA), which when exposed
to cancerous GalNAcα1-O-Ser/Thr-R,
"A-like"
(Tn) glycosylation, suggests to provide invasion of the parasite into a cancer
cell as well. In contrast, the human blood group O is currently discussed to
have a survival advantage of the overall risk of developing cancer, it rarely
develops life-threatening malaria disease and offers the widest functional
flexibility in adaptive and germline-encoded innate immunity.
Central immunological position of the human blood group O in light of the Duffy groups.
Creators: name: Arend, Peter
Publisher: name: Figshare
Year: 2017
Subjects: Cancer

description: Development of the blood group A
phenotype is associated with the impaired formation of adaptive and innate
immunoglobulins due to clonal selection and phenotypic, glycosidic accommodation
of plasma proteins. Compared with individuals from blood group O(H),
individuals with blood group A have a significantly higher risk of developing
certain types of cancer and exhibit strong susceptibility to malaria tropica or
infection by Plasmodium falciparum. Although
malaria tertiana, caused by Plasmodium vivax, is the best-documented type of malaria, P. falciparum causes the most severe
disease. In both malaria types, the risk of developing disease is molecularly
strongly related to blood group phenotype formation, although outcomes are
reverse; while the Duffy positive (Fya) individuals
are most susceptible to P. vivax
infections but the Duffy antigen receptor
for chemokines (DARC) protein exerts marked cancer regulation, human blood
group A shows significant susceptibility to both life-threatening infection by P. falciparum and distinct types of cancer.
Aside from the molecular features of the DARC protein, the phenotype-determining
glycotransferase(s) from blood group A, affecting the levels of anti-A/Tn
cross-reactive immunoglobulins, might also explain the entry of Plasmodium merozoites into the host's red
blood cells (RBCs) via the parasite's serine repeat antigen (SERA), which when exposed
to cancerous GalNAcα1-O-Ser/Thr-R,
"A-like"
(Tn) glycosylation, suggests to provide invasion of the parasite into a cancer
cell as well. In contrast, the human blood group O is currently discussed to
have a survival advantage of the overall risk of developing cancer, it rarely
develops life-threatening malaria disease and offers the widest functional
flexibility in adaptive and germline-encoded innate immunity.
CIGRE Session 2024 C1-C4 Workshop Resilience by design (HVDC-WISE project)
Creators: name: Foote, Colin
name: Morel, Florent
Publisher: name: Zenodo
Year: 2025
Subjects: HVDC
Grids
Transmission
grid resilience

description: The HVDC-WISE project contributed to the CIGRE Paris Session “Resilience by Design” workshop on 27 August 8:30am-12:30pm (room 342 A-B, level 3), focused on the methods and best practices necessary to design and operate power grids that are more resilient to disruptions and can recover quickly from outages. The workshop featured a general presentation of the HVDC-WISE project, followed by a detailed discussion on the resilience aspects of HVDC systems and some specific project results.
Demystifying Large Language Models
Creators: name: O'Reilly, Martin
Publisher: name: Zenodo
Year: 2024
Subjects: rse

description: Large language models (LLMs) have taken the world by storm over the past year or two, sparking a huge number of LLM-powered tools, products and start-ups. However, despite being readily accessible to us all, how these models work remains a mystery to many of us.
This talk will demysitify LLMs by providing an intuitive understanding of how they build upon key prior advances to successfully cross the uncanny valley of text generation, and provide an overview of the surprising range of other tasks mastering this "one weird trick" seems to let these models perform.
Participants will gain an intuition of how LLMs work by immersive participation in a human-powered "large audience model", as well as the opportunity to pit the latest LLMs against our very own RSECon Turing test.
This talk will provide participants with a conceptual understanding of how LLMs work, the history of prior advances that made them possible, and what makes these models "foundational". It will also explore some of the strengths and limitations of these models, including examples of where they do surpisingly well and where they can struggle with suprisingly similar tasks.
This talk won't make you an expert on word embeddings, deep neural networks or transformers, but it will give you a peek behind the curtain of how these seemingly magical models work and hopefully give you some tools to explain them to friends and family in an intuitive way.
A recording of this session is available on YouTube: https://youtu.be/NnXCdG6nsWE
Additional file 1 of Combinatorial functionomics identifies HDAC6-dependent molecular vulnerability of radioresistant head and neck cancer
Creators: name: Chan, Sharon Pei Yi
name: Yeo, Celestia Pei Xuan
name: Hong, Boon Hao
name: Tan, Evelyn Mui Cheng
name: Beh, Chaw Yee
name: Yeo, Eugenia Li Ling
name: Poon, Dennis Jun Jie
name: Chu, Pek Lim
name: Soo, Khee Chee
name: Chua, Melvin Lee Kiang
name: Chow, Edward Kai-Hua
Publisher: name: figshare
Year: 2025
Subjects: Biophysics
Biochemistry
Space Science
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Hematology

description: Additional file 1 (Fig. S1 Characterization of in vitro isogenic models of radioresistance generated from serial irradiation method. a Survival curve of WT and RR FaDu and HK-1 cells following increasing doses of 0 to 4 Gy X-irradiation. b Growth curve of WT and RR FaDu and HK-1 cells derived from CTG luminescence values taken at the indicated timepoints. c Wound scratch assay performed on WT and RR FaDu cells with (i) representative images and accompanying quantification of (ii) area of wound closure (%), rate of migration (μM/h) and scratch width (μM). d Wound scratch assay performed on WT and RR HK-1 cells with (i) representative images and accompanying quantification of (ii) area of wound closure (%), rate of migration (μM/h) and scratch width (μM). All data presented as mean ± SD of three biological replicates. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. All statistical analyses were performed using two-tailed Student’s t test.)
title: Die Zentrallage Kassels
Creators: name: Vahrenkamp, Richard
Publisher: name: Universität Kassel
Year: 2020
Subjects: subject: Kassel
subject: Guxhagen
subject: Verkehrspolitik
subject: 1920er Jahre
subject: Hafraba
subject: Busverkehr
subject: Rudolf Herz
subject: Holocaust Denkmal
subject: Vollmarshausen
subject: Zwangsarbeit
subject: Henschel LKW
subject: Henschel Dampfwagen
subject: Tankstelle
subject: Heiligenrode
subject: Homberg
subject: Fuldabrücke
subject: Eisenach
subject: Nörten
subject: Vollbehr
subject: Hannoversch Münden
subject: Werratalbrücke
subject: Henschelbus
subject: Stromlinienform
subject: Schloss Neuenstein
subject: Arbeitslager
classificationCode: 330
subject: 330
classificationCode: 900
subject: 900
classificationCode: Kassel
subject: Kassel
classificationCode: Guxhagen
subject: Guxhagen
classificationCode: Werratalbrücke Hörschel (Eisenach)
subject: Werratalbrücke Hörschel (Eisenach)
classificationCode: HAFRABA e.V.
subject: HAFRABA e.V.
classificationCode: Verkehrspolitik
subject: Verkehrspolitik
classificationCode: Autobahnbau
subject: Autobahnbau
classificationCode: Zwangsarbeit
subject: Zwangsarbeit
classificationCode: Arbeitslager
subject: Arbeitslager
classificationCode: Geschichte 1920-2000
subject: Geschichte 1920-2000

description:
Das Paper zeigt die verkehrspolitische Diskussion in Kassel 1920 bis 1935 auf, die Planungen der Hafraba in Hessen und Kassel, das Autobahnprojekt in der NS-Zeit und den Autobahnbau in Nordhessen und die Propagandashows der Eröffnungen. Geschildert werden Arbeitslager und Zwangsarbeit.
Hecullus balli Beamer 1937
Creators: name: Zahniser, James N.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadellidae
Hecullus
Hecullus balli

description: balli Beamer, 1937 (United States)
bracteatus Ball, 1901 (United States)
mexicanus n. sp. (Mexico)
Key to species of Hecullus
1. Female 8.0 mm or longer (43A1,B1, 48A,B); female head length 1.7x or more interocular width (43A1, 48A); known males (H. balli) with forewings pale and without distinct shading along veins (43A2,B2), head and pronotum without distinct longitudinal banding pattern (43A2), aedeagus in lateral view with apex rounded (43H), and ventral processes of aedeagus projecting caudad from ventral side of aedeagal base (43H)............................................................ 2
1’. Female 7.0 mm or less (44A1,B1); female head length 1.3x or less interocular width (44A1); male forewings with brown shading along vein margins (44A2,B2), head and pronotum with distinct longitudinal banding pattern (44A2), aedeagus in lateral view with apex attenuated to sharp apex (44H), and ventral processes not projecting caudad and closely following curvature of aedeagus (44H)............................................................................ H. bracteatus
2. Female head length 2.0x or more interocular width (43A1); face without distinct broad brown bands or other distinct brown markings (43B1)................................................................................ H. balli
2’. Female head length 1.7–1.8x interocular width (48A); face with broad brown to dark brown band along anterolateral portion of frontoclypeus, continuing beneath eye and onto ventral side of thorax (48B,C,Q); face with brown mark from basolateral corner of clypellus to medial margin of lorum, widening along lorum margin toward apex (48C).................. H. mexicanus
description: Published as part of Zahniser, James N., 2021, Revision of the New World leafhopper tribe Faltalini (Hemiptera: Cicadellidae: Deltocephalinae) and the evolution of brachyptery, pp. 1-160 in Zootaxa 4954 (1) on page 71, DOI: 10.11646/zootaxa.4954.1.1, http://zenodo.org/record/4690775
Pseudonagoda Holloway 1990
Creators: name: Wu, Jun
name: Yang, Xiao-Feng
name: Han, Hui-Lin
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Limacodidae
Pseudonagoda

description: Genus Pseudonagoda Holloway, 1990
Pseudonagoda Holloway, 1990: 59.
Type species Pseudonagoda naessigi Holloway, 1990 by original designation. Type locality Indonesia (N. Sumatra).
description: Published as part of Wu, Jun, Yang, Xiao-Feng & Han, Hui-Lin, 2022, Discovery of the genus Pseudonagoda Holloway, 1990 (Lepidoptera: Limacodidae) from China, with description of a new species and notes on the immature stages, pp. 293-300 in Zootaxa 5099 (2) on page 294, DOI: 10.11646/zootaxa.5099.2.9, http://zenodo.org/record/6048598
Effetti degli amminoacidi a catena ramificata (BCAA) sull’eccitabilità di neuroni corticali in coltura primaria e confronto con il modello murino di sclerosi laterale amiotrofica, G93A
Creators: name: CURCIO, LIVIA
Publisher: name: Università degli Studi di Roma "Tor Vergata"
Year: 2010
Subjects: subject: patch clamp; rapamicina; neuroni; G93A; BCAA
subject: patch clamp
subject: rapamicina
subject: neuroni
subject: G93A
subject: BCAA

description: 22. ciclo
description: 1 LA SCLEROSI LATERALE AMIOTROFICA - 1.1 Ipotesi patogenetiche di SLA - 1.1.1 SOD1 (Cu/Zn‐Superossido dismutasi) - 1.1.2 Alterazioni mitocondriali, vacuolizzazione e stress ossidativo - 1.1.3 Anormalità citoscheletriche e aggregazione proteica - 1.1.4 Meccanismi intercellulari nella patogenesi della SLA - 1.1.5 Danno eccitossico - 1.1.6 I canali ionici nella SLA - 1.1.7 Fattori di rischio ambientali - 1.2 Attività fisica e insorgenza di SLA - 1.3 Ipotesi di SLA nei calciatori in Italia - 1.4 Integrazione alimentare durante l’attività sportiva - 1.5 Amminoacidi a catena ramificata - 1.6 Metabolismo e fabbisogno umano di BCAA - 1.7 Gli amminoacidi a catena ramificata nel SNC ed effetto sui meccanismi di fatica centrale - 1.8 Possibile implicazione dei BCAA nella SLA. - 2 IL COMPLESSO MTOR (MAMMALIAN TARGET OF RAPAMYCIN). - 3 I CANALI IONICI VOLTAGGIO‐DIPENDENTI E LA TRASMISSIONE SINAPTICA - 3.1 Genesi ionica dei potenziali d’azione 51 3.2 I canali ionici del sodio voltaggio dipendenti - 3.3 I canali ionici del calcio Voltaggio dipendenti - SCOPO DELLO STUDIO - 4 MATERIALI E METODI - 4.1 Colture cellulari - 4.2 Trattamento delle cellule corticali - 4.3 Registrazione elettrofisiologiche - 4.3.1 La tecnica del Patch‐Clamp - 4.3.2 Configurazioni - 4.3.3 Current‐clamp e Voltage‐clamp - 4.3.4 Le proprietà elettriche della membrana cellulare - 4.3.5 Elettrodi e soluzioni - 4.3.6 Apparato sperimentale - 4.4 Analisi dei dati. - 5 RISULTATI - 5.1 Effetto dei BCAA sulle proprietà passive e attive di neuroni corticali - 5.2 Specificità dell’effetto di BCAA - 5.3 Effetto della Rapamicina - 5.4 Confronto con il modello G93A - 5.5 Effetto dell’esposizione di BCAA sulla funzionalità dei canali ionici voltaggiodipendenti - 5.5.1 Studio dei canali ionici voltaggio‐dipendenti del Sodio: corrente transiente e persistente - 5.5.2 Caratterizzazione farmacologica dei canali ionici del calcio voltaggio dipendenti . - 6 DISCUSSIONE - 7 BIBLIOGRAFIA
Central immunological position of the human blood group O in light of the Duffy groups.
Creators: name: Arend, Peter
Publisher: name: Figshare
Year: 2017
Subjects: Cancer

description: Blood
group A phenotype development is associated with the impaired formation of
adaptive and innate immunoglobulins due to clonal selection and phenotypic,
glycosidic accommodation of the plasma proteins. This group is significantly
burdened with an increased risk of developing distinct types of cancer when
compared with the blood group O and is exerting strong susceptibility to Malaria
tropica or infection by Plasmodium
falciparum. While Malaria tertiana, caused by Plasmodium vivax, ovale and
knowlesi, is the best documented type of malaria, P. falciparum causes the most severe disease. In both malaria
types, the risk of developing the disease is molecularly
strongly related to blood group phenotype formation, although with reverse outcomes; while the Duffy positive (Fya)
individuals are most susceptible to P. vivax infections but the Duffy antigen receptor for chemokines (DARC) protein
exerts cancer regulation, the human blood group A shows significant susceptibility
to both life-threatening infection by P.
falciparum and distinct types of cancer. Aside from the molecular features
of the DARC protein, the phenotype-determining glycotransferase(s) from blood
group A, affecting the levels of anti-A/Tn cross-reactive immuno-globulins, may also
initiate the entry of Plasmodium merozoites
into the host's red blood cells (RBCs) via the parasite's serine repeat antigen
(SERA), which when exposed to cancerous GalNAcα1-O-Ser/Thr-R, "A-like" (Tn) glycosylation, may provide the invasion of the parasite
into a cancer cell as well. In contrast, the human blood group O is currently
discussed to have a survival advantage of the overall risk of developing cancer;
moreover, it rarely develops life-threatening malaria disease and offers the
widest functional flexibility in adaptive and germline-encoded innate immunity.
Hecullus balli
Creators: name: Zahniser, James N.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadellidae
Hecullus
Hecullus balli

description: Hecullus balli (Beamer)
(Figs. 43, 47)
Hecalus balli Beamer, 1937:12 [original description, morphology]
Hecullus balli: Oman, 1949: 31 [listed, classification]; Hamilton, 2000: 434–436 [morphology, misidentification]; Zahniser, 2007 [online catalogue]
Diagnosis. H. balli can be distinguished from the other species in the genus by its size (male 5.0– 5.5 mm, female 8.5–9.5 mm), female head length 2x or more interocular width, female face without distinct broad brown bands or other distinct brown markings, males with forewings pale and without distinct shading along veins, male head and pronotum without distinct striping, aedeagus in lateral view with apex rounded, and ventral processes of aedeagus projecting caudad from ventral side of aedeagal base.
Material examined. 10♂, 8♀, 1n: AZ: Cochise, 24-VIII-1935, R.H. Beamer [USNM]. 1♂, 1♀, same data [INHS]. 3♂: AZ: Wilcox, 19-VIII-1934 [USNM]. 15♂, 25♀, 13n: ZA: Wilcox, 6-IX-1936, E.D. Ball [USNM]. 10♂: AZ: Benson, 10-IX-1935, E.D. Ball [USNM]; 1♂: AZ: Patagonia, 7-VIII-1929, E.D. Ball [USNM].
Distribution. H. balli is known from the United States in a limited area of southeastern Arizona.
Remarks. Illustrations stated to be of H. balli by Hamilton (2000; Figs. 7, 14) appear to be of H. bracteatus. The illustrations given here are the first for this species.
description: Published as part of Zahniser, James N., 2021, Revision of the New World leafhopper tribe Faltalini (Hemiptera: Cicadellidae: Deltocephalinae) and the evolution of brachyptery, pp. 1-160 in Zootaxa 4954 (1) on pages 72-73, DOI: 10.11646/zootaxa.4954.1.1, http://zenodo.org/record/4690775
Central immunological position of the human blood group O in light of the Duffy groups.
Creators: name: Arend, Peter
Publisher: name: Figshare
Year: 2017
Subjects: Cancer

description: Blood
group A phenotype development is associated with the impaired formation of
adaptive and innate immunoglobulins due to clonal selection and phenotypic,
glycosidic accommodation of the plasma proteins. This group is significantly
burdened with an increased risk of developing distinct types of cancer when
compared with the blood group O and is exerting strong susceptibility to Malaria
tropica or infection by Plasmodium
falciparum. While Malaria tertiana, caused by Plasmodium vivax, ovale and
knowlesi, is the best documented type of malaria, P. falciparum causes the most severe disease. In both malaria
types, the risk of developing the disease is, although with reverse outcomes, molecularly
strongly related to blood group phenotype formation; while the Duffy positive (Fya)
individuals are most susceptible to P. vivax infections but the Duffy antigen receptor for chemokines (DARC) protein
exerts cancer regulation, the human blood group A shows significant susceptibility
to both life-threatening infection by P.
falciparum and distinct types of cancer. Aside from the molecular features
of the DARC protein, the phenotype-determining glycotransferase(s) from blood
group A, affecting the levels of anti-A/Tn cross-reactive immuno-globulins, may also
initiate the entry of Plasmodium merozoites
into the host's red blood cells (RBCs) via the parasite's serine repeat antigen
(SERA), which when exposed to cancerous O-GalNAc
"A-like" (Tn) glycosylation, may provide the invasion of the parasite
into a cancer cell as well. In contrast, the human blood group O is currently
discussed to have a survival advantage of the overall risk of developing cancer;
moreover, it rarely develops life-threatening malaria disease and offers the
widest functional flexibility in adaptive and germline-encoded innate immunity.
Additional file 4 of Combinatorial functionomics identifies HDAC6-dependent molecular vulnerability of radioresistant head and neck cancer
Creators: name: Chan, Sharon Pei Yi
name: Yeo, Celestia Pei Xuan
name: Hong, Boon Hao
name: Tan, Evelyn Mui Cheng
name: Beh, Chaw Yee
name: Yeo, Eugenia Li Ling
name: Poon, Dennis Jun Jie
name: Chu, Pek Lim
name: Soo, Khee Chee
name: Chua, Melvin Lee Kiang
name: Chow, Edward Kai-Hua
Publisher: name: figshare
Year: 2025
Subjects: Biophysics
Biochemistry
Space Science
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Hematology

description: Additional file 4 (Fig. S4 Target validation screen using Class I or II selective HDAC inhibitors. a Single drug and combination dose response curves of AZD7762 with either Romidepsin (Class I selective HDAC inhibitor) or Roybinostat (Class II selective inhibitor) across (i) WT and (ii) RR FaDu, with accompanying b Fa-CI (fraction affected-combination index) plot. c Single drug and combination dose response curves of AZD7762 with either Romidepsin or Roybinostat across (i) WT and (ii) RR HK-1, with accompanying d Fa-CI plot. Combination indices of log(CI) <0 across a range of effect sizes (Fa) is indicative of a synergistic interaction. Data presented as means ± SD of two technical replicates.)
AUDIT CHALLENGES IN PUBLIC HOSPITALS IN RWANDA: A CASE STUDY OF BUDGET EXECUTION
Creators: name: 1Mbonigaba Celestin, 2Abdourahman Farah & 3Ahmed Mansour, 4Kiuri Daniel
Publisher: name: Zenodo
Year: 2013

description: This study investigates audit challenges in Rwandan public hospitals, focusing on budget execution. Using a qualitative case study methodology, data were collected from secondary sources, including government and audit reports from 2008 to 2012. Statistical analysis revealed significant issues such as discrepancies averaging 460 million RWF between allocated and actual expenditures (t = 8.15, p < 0.01), inadequate staffing with only 47.6% of required auditors available by 2012, and declining adherence to procurement procedures (compliance dropped from 80% in 2008 to 60% in 2012). Furthermore, logistic regression demonstrated that improved procurement compliance reduced misallocation likelihood by 40% (p < 0.001). These findings underscore the urgent need for reforms in financial reporting, auditor capacity building, and enforcement of procurement standards. Recommendations include streamlining reporting systems, increasing auditor training, and enhancing oversight mechanisms to promote transparency and accountability in public healthcare financial management.
Central immunological position of the human blood group O phenotype in light of the Duffy groups.
Creators: name: Arend, Peter
Publisher: name: Figshare
Year: 2017
Subjects: Cancer

description: Blood
group A phenotype development is associated with the impaired formation of
adaptive and innate immunoglobulins due to clonal selection and phenotypic,
glycosidic accommodation of the plasma proteins. This group is significantly
burdened with an increased risk of developing distinct types of cancer when
compared with the blood group O and is exerting strong susceptibility to Malaria
tropica or infection by Plasmodium
falciparum. While Malaria tertiana, caused by Plasmodium vivax, ovale and
knowlesi, is the best documented type of malaria, P. falciparum causes the most severe disease. In both malaria
types, the risk of developing the disease is, although with reverse outcomes, molecularly
strongly related to blood group phenotype formation; while the Duffy positive (Fya)
individuals are most susceptible to P. vivax infections but the Duffy antigen receptor for chemokines (DARC) protein
exerts cancer regulation, the human blood group A shows significant susceptibility
to both life-threatening infection by P.
falciparum and distinct types of cancer. Aside from the molecular features
of the DARC protein, the phenotype-determining glycotransferase(s) from blood
group A, affecting the levels of anti-A/Tn cross-reactive immunoglobulins, may also
initiate the entry of Plasmodium merozoites
into the host's red blood cells (RBCs) via the parasite's serine repeat antigen
(SERA), which when exposed to cancerous O-GalNAc
"A-like" (Tn) glycosylation, may provide the invasion of the parasite
into a cancer cell as well. In contrast, the human blood group O is currently
discussed to have a survival advantage of the overall risk of developing cancer;
moreover, it rarely develops life-threatening malaria disease and offers the
widest functional flexibility in adaptive and germline-encoded innate immunity.
Additional file 5 of Combinatorial functionomics identifies HDAC6-dependent molecular vulnerability of radioresistant head and neck cancer
Creators: name: Chan, Sharon Pei Yi
name: Yeo, Celestia Pei Xuan
name: Hong, Boon Hao
name: Tan, Evelyn Mui Cheng
name: Beh, Chaw Yee
name: Yeo, Eugenia Li Ling
name: Poon, Dennis Jun Jie
name: Chu, Pek Lim
name: Soo, Khee Chee
name: Chua, Melvin Lee Kiang
name: Chow, Edward Kai-Hua
Publisher: name: figshare
Year: 2025
Subjects: Biophysics
Biochemistry
Space Science
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Hematology

description: Additional file 5 (Fig. S5 Class II selective HDAC inhibitor preferentially targets RR-HNC models. Representative immunoblots of histone and non-histone proteins regulated by HDACs in WT and RR a FaDu and b HK-1 treated singly with Romidepsin (class I selective HDACi) or Roybinostat (class II selective HDACi), or in combination with AZD7762 for 48h.)
Artists Making Books. Pages of Refuge Lettura della mostra all’American Academy (Roma 2024)
Creators: name: Benedetti, Asia
Publisher: name: La Rivista di Engramma
Year: 2024
Subjects: Artists
Books
Medium
Exhibition

description: The American Academy in Rome is hosting an exhibition called "Artists making Books. Pages of Refuge", which showcases an anthology of exceptional artworks from the 20th century until today. In this exhibition, artists explore the use of books as a creative medium. The exhibition features a diverse range of books in various forms, formats, and with verbal and visual elements. These artworks demonstrate artistic operations and material verifications centered around the book-form. The artists use books as carriers of ideas and experiences, reflecting the evolution of artistic languages and societal changes. The exhibition emphasizes the liberation and playfulness that comes with utilizing the page as a space, allowing artists to break free from the dominance of verbal language. This article traces the exhibition, highlighting the dialogue between the artists' thoughts and aesthetic elaborations on the medium, while also showcasing the similarities between the artistic poetics of different artists.
Acropimpla didyma
Creators: name: Varga, Oleksandr
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Ichneumonidae
Acropimpla
Acropimpla didyma

description: Acropimpla didyma (Gravenhorst, 1829)
Records. Eastern Ukraine (Kasparyan, 1981).
Material examined. Cherkasy Reg.: 1 ♀, Kaniv NR, SN, 12.v.1972, leg. V. Tolkanitz; Khmelnytskyi Reg.: 1 ♀, Netishyn, SN, 29.vii.1999; Kyiv Reg.: 1 ♀, Kyiv, Pyrogiv, SN, 12.viii.2000, leg. A. Kotenko.
Distribution. Palaearctic; Ukraine: Cherkasy, Khmelnytskyi and Kyiv Regs.
Biology. CEMF, EEFS. May–August.
description: Published as part of Varga, Oleksandr, 2019, Taxonomy and distribution of pimpline parasitoids (Hymenoptera, Ichneumonidae, Pimplinae) in Ukraine, pp. 1-65 in Zootaxa 4693 (1) on page 13, DOI: 10.11646/zootaxa.4693.1.1, http://zenodo.org/record/3529018
Towards adoption of FAIR4RS: equipping researchers with FAIR research software skills
Creators: name: James, Tamora
name: Thomas, Romain
Publisher: name: Zenodo
Year: 2024
Subjects: rse

description: Recently there has been growing recognition that research software, defined as "source code files, algorithms, scripts, computational workflows and executables that were created during the research process or for a research purpose"[1], should adhere to the FAIR (Findable, Accessible, Interoperable and Reusable) principles[2], as well as meeting broader open research goals such as reproducibility. A set of FAIR guidelines for research software (FAIR4RS) has been developed to provide a framework for the development of FAIR research software[1]. However, many researchers require additional practical support to meet these guidelines. Training is one aspect of cultural change needed to promote uptake of the FAIR4RS principles[3].During this panel discussion we will consider the challenges involved in equipping researchers with the skills needed to create FAIR research software: what topics need to be covered, how can we reach our target audience, how can we fund these activities and how can we motivate trainees to carry forward the FAIR4RS principles?This panel will benefit members of the community who are involved in training researchers in better research software practices or who work in settings where research outputs include software. We invite attendees to share their experiences and pool ideas for future provision of FAIR4RS training within the RSE community.[1] Barker et al., 2022, 'Introducing the FAIR Principles for Research Software'.[2] Wilkinson et al., 2016, 'The FAIR Guiding Principles for Scientific Data Management and Stewardship'.[3] Barker et al., 2024, 'The FAIR for Research Software Principles after two years'.
Panel members
Neil Chue Hong, University of Edinburgh, Software Sustainability InstituteSarah Jaffa, University of ManchesterCarlos Martinez-Ortiz, Netherlands eScience CenterRomain Thomas, University of SheffieldSamantha Wittke, CSC - IT Center for Science, Finland
A recording of this session is available on YouTube: https://youtu.be/exOyu3dxwy0
Central immunological position of the human blood group O phenotype in light of the Duffy groups.
Creators: name: Arend, Peter
Publisher: name: Figshare
Year: 2017
Subjects: Cancer

description: Blood
group A phenotype development is associated with the impaired formation of
adaptive and innate immunoglobulins due to clonal selection and phenotypic,
glycosidic accommodation of the plasma proteins. This group is significantly
burdened with an increased risk of developing distinct types of cancer when
compared with the blood group O and is exerting strong susceptibility to Malaria
tropica or infection by Plasmodium
falciparum. While Malaria tertiana, caused by Plasmodium vivax, ovale and
knowlesi, is the best documented type of malaria, P. falciparum causes the most severe disease. In both malaria
types, the risk of developing the disease is, although with reverse outcomes, molecularly
strongly related to blood group phenotype formation; while the Duffy positive (Fya)
individuals are most susceptible to P. vivax infections but the Duffy antigen receptor for chemokines (DARC) protein
exerts cancer regulation, the human blood group A shows significant susceptibility
to both life-threatening infection by P.
falciparum and distinct types of cancer. Aside from the molecular features
of the DARC protein, the phenotype-determining glycotransferase(s) from blood
group A, affecting the levels of anti-A/Tn cross-reactive immunoglobulins, may also
initiate the entry of Plasmodium merozoites
into the host's red blood cells (RBCs) via the parasite's serine repeat antigen
(SERA), which when exposed to cancerous O-GalNAc
"A-like" (Tn) glycosylation, may provide the invasion of the parasite
into a cancer cell as well. In contrast, the human blood group O phenotype is
currently discussed to have a survival advantage of the overall risk of
developing cancer; moreover, it rarely develops life-threatening malaria disease
and offers the widest functional flexibility in adaptive and germline-encoded
innate immunity.
Additional file 8 of Combinatorial functionomics identifies HDAC6-dependent molecular vulnerability of radioresistant head and neck cancer
Creators: name: Chan, Sharon Pei Yi
name: Yeo, Celestia Pei Xuan
name: Hong, Boon Hao
name: Tan, Evelyn Mui Cheng
name: Beh, Chaw Yee
name: Yeo, Eugenia Li Ling
name: Poon, Dennis Jun Jie
name: Chu, Pek Lim
name: Soo, Khee Chee
name: Chua, Melvin Lee Kiang
name: Chow, Edward Kai-Hua
Publisher: name: figshare
Year: 2025
Subjects: Biophysics
Biochemistry
Space Science
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Hematology

description: Additional file 8 (Fig. S8 Analysis of SP1 DNA binding activity in WT and RR FaDu. Competition and knockdown assays to determine binding specificity of SP1 to its consensus sequence. C1 and C2 are resulting DNA-protein complexes formed.)
Hecullus mexicanus Zahniser 2021, n. sp.
Creators: name: Zahniser, James N.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadellidae
Hecullus
Hecullus mexicanus

description: Hecullus mexicanus n. sp.
(Figs. 10, 48)
Diagnosis. H. mexicanus can be distinguished from other Hecullus by its size (female, 8.3 mm), female head length 1.7–1.8x interocular width, female face with broad brown to dark brown band along anterolateral portion of fron-
toclypeus continuing beneath eye and onto ventral side of thorax, face with brown mark from basolateral corner of clypellus to medial margin of lorum and widening along lorum margin toward apex.
Body. Female 8.3 mm; head length 1.7–1.8x interocular width. Forewing apex truncate; with many extra crossveins, but venation not completely reticulate.
Color. Female face with broad brown to dark brown band along anterolateral portion of frontoclypeus continuing beneath eye and onto ventral side of thorax, brown bands weak at apex of frontoclypeus; frontoclypeus ivory medially; face with brown mark from basolateral corner of clypellus to medial margin of lorum and widening along lorum margin toward apex. Legs ivory with distinct brown markings basally on anterior side of profemur and subapically and apically on anterior side of meso- and metafemur; with other scattered brown markings.
Male. Unknown.
Female. Sternite VII relatively deeply excavated medially, forming pair of bluntly pointed lateral lobes; on each side, deepest excavation reaching to near midlength of sternite; medially with distinct medial rounded lobe; margin laterad of median lobe slightly undulate.
Material examined. HOLOTYPE: 1♀, MEXICO, Puebla, 6.3 km E of Azumbilla, 2350 m., 18.63385ºN 97.34344ºW, 10-XI-2005, R. Rakitov, #05-238 [INHS].
Distribution. This species is known only from a single female specimen from the state of Puebla, Mexico. It is by far the southern-most record for the genus, around 1900km SE of the nearest record in southwest New Mexico.
Etymology. The adjectival species name highlight the finding of the new species in Mexico.
Remarks. Collection locality notes (R. Rakitov, pers. comm.) recorded the habitat as a dry meadow among pine-yucca forest, with Opuntia and many dry forbs. It would be preferable to describe this species with at least one male specimen, but H. mexicanus is clearly different and easily separated from the other two species in the genus based on the female. Its discovery substantially expands the known geographic range of the genus. Future collecting efforts directed near the type locality may reveal more specimens including males.
description: Published as part of Zahniser, James N., 2021, Revision of the New World leafhopper tribe Faltalini (Hemiptera: Cicadellidae: Deltocephalinae) and the evolution of brachyptery, pp. 1-160 in Zootaxa 4954 (1) on pages 73-75, DOI: 10.11646/zootaxa.4954.1.1, http://zenodo.org/record/4690775
title: L’employee engagement e la focalizzazione sui core value quali leve di un approccio integrato alla sustainable excellence per la competitività nel lungo periodo
title: Employee engagement and focus on core values as leverages of an integrated approach to sustainable excellence for the competitiveness in the long period
titleType: AlternativeTitle
Creators: name: SPADA, CATERINA
Publisher: name: Università degli Studi di Roma "Tor Vergata"
Year: 2010
Subjects: subject: corporate sustainability; excellence; employee engagement
subject: cultura industriale
subject: corporate sustainability
subject: excellence
subject: employee engagement
subject: cultura industriale

description: 22. ciclo
Additional file 9 of Combinatorial functionomics identifies HDAC6-dependent molecular vulnerability of radioresistant head and neck cancer
Creators: name: Chan, Sharon Pei Yi
name: Yeo, Celestia Pei Xuan
name: Hong, Boon Hao
name: Tan, Evelyn Mui Cheng
name: Beh, Chaw Yee
name: Yeo, Eugenia Li Ling
name: Poon, Dennis Jun Jie
name: Chu, Pek Lim
name: Soo, Khee Chee
name: Chua, Melvin Lee Kiang
name: Chow, Edward Kai-Hua
Publisher: name: figshare
Year: 2025
Subjects: Biophysics
Biochemistry
Space Science
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Hematology

description: Additional file 9 (Fig. S9 SP1 ChIP-qPCR assay in WT and RR HK-1 cells. ChIP and qPCR analysis of SP1 binding levels at MYC, RAD51 or FOXM1 activating promoter regions in WT and RR HK-1 cells. Normal rabbit IgG antibody was used as a control for non-specific binding in ChIP assays.)
Central immunological position of the human blood group O(H) phenotype in light of the Duffy groups.
Creators: name: Arend, Peter
Publisher: name: Figshare
Year: 2017
Subjects: Cancer

description: Blood
group A phenotype development is associated with the impaired formation of
adaptive and innate immunoglobulins due to clonal selection and phenotypic,
glycosidic accommodation of the plasma proteins. This group is significantly
burdened with an increased risk of developing distinct types of cancer when
compared with the blood group O(H), and is exerting strong susceptibility to Malaria
tropica or infection by Plasmodium
falciparum. While Malaria tertiana, caused by Plasmodium vivax and ovale, is the best documented type of malaria, P. falciparum causes the most severe disease.
In both malaria types, the risk of developing the disease is, although with
reverse outcomes, molecularly strongly related to blood group phenotype
formation; while the Duffy positive (Fya) individuals are most susceptible to P. vivax infections and the
human blood group A shows statistically significant susceptibility to severe P. falciparum infection, and to distinct types of cancer, the Duffy antigen receptor for chemokines (DARC) protein
exerts a marked cancer regulating activity. Aside from the well
documented pathogenesis
characterizing the P. vivax
infections of Duffy Fya individuals, the phenotype-determining glycotransferase(s)
from blood group A, assumingly affecting the levels of anti-A/Tn cross-reactive
immunoglobulins, may also initiate the entry of Plasmodium merozoites into the host's red blood cells (RBCs) via
the parasite's serine repeat antigen (SERA), which when exposed to cancerous O-GalNAc "A-like" (Tn) glycosylation, may provide the invasion of the parasite into a cancer cell as well. Consequently, the blood group O(H) phenotype
rarely develops severe malaria disease, beyond that is currently discussed to
have a survival advantage of the overall risk of developing cancer, and appears
to offer the widest functional flexibility in adaptive and germline-encoded
innate immunity.
Additional file 10 of Combinatorial functionomics identifies HDAC6-dependent molecular vulnerability of radioresistant head and neck cancer
Creators: name: Chan, Sharon Pei Yi
name: Yeo, Celestia Pei Xuan
name: Hong, Boon Hao
name: Tan, Evelyn Mui Cheng
name: Beh, Chaw Yee
name: Yeo, Eugenia Li Ling
name: Poon, Dennis Jun Jie
name: Chu, Pek Lim
name: Soo, Khee Chee
name: Chua, Melvin Lee Kiang
name: Chow, Edward Kai-Hua
Publisher: name: figshare
Year: 2025
Subjects: Biophysics
Biochemistry
Space Science
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Hematology

description: Additional file 10 (Fig. S10 Comparative transcriptomic profiling of isogenic RR models treated with or without siHDAC6. a Correlation heatmap of 24 samples from triplicated experiment in FaDu and HK-1 models. The differences between treatment type were larger than the cell phenotypes. b Volcano plot of differentially expressed (DE) genes identified from siNC-RR compared to siNC-WT cells. c Volcano plot of differentially expressed (DE) genes identified from siHDAC6-RR compared to siNC-RR cells. d Sensitivity analysis of the output from gene selection refinement process in both FaDu and HK-1, and common genes identified from intersection analysis of both cell lines.)
Additional file 12 of Combinatorial functionomics identifies HDAC6-dependent molecular vulnerability of radioresistant head and neck cancer
Creators: name: Chan, Sharon Pei Yi
name: Yeo, Celestia Pei Xuan
name: Hong, Boon Hao
name: Tan, Evelyn Mui Cheng
name: Beh, Chaw Yee
name: Yeo, Eugenia Li Ling
name: Poon, Dennis Jun Jie
name: Chu, Pek Lim
name: Soo, Khee Chee
name: Chua, Melvin Lee Kiang
name: Chow, Edward Kai-Hua
Publisher: name: figshare
Year: 2025
Subjects: Biophysics
Biochemistry
Space Science
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Hematology

description: Additional file 12.
Tracking the Carbon Cost of Optimization Algorithms: A case study
Creators: name: Huntley, Jessica
Publisher: name: Zenodo
Year: 2024
Subjects: rse

description: One of the biggest global challenges is tackling climate change and building a sustainable future. The IT sector is estimated to account for 2-6% of global carbon emissions and is set to rise as much as 20% by 2030. Whilst software on its own doesn't emit CO2, understanding the cost of running it is important so that the way it is developed, and the way it is used, can be optimised for minimal carbon emissions. There are several carbon tracking tools available for estimating hardware electricity power consumption, allowing users and developers to quantify the carbon cost of running a program and identify areas for improvement.
FitBenchmarking (https://fitbenchmarking.github.io/) is an open source Python package that allows users to compare the performance of different optimization algorithms and their implementations across various fitting problems, through metrics such as runtime and accuracy. In this talk, I will outline how a new carbon emissions metric has been added to FitBenchmarking, some of the challenges faced along the way, and the insight that reporting emissions offers developers and users of fitting software.
A recording of this session is available on YouTube: https://youtu.be/lEkYZxXJ3Kk
Yap is regulated by phosphorylation at the G2/M transition
Creators: name: BERTINI, EFREM
Publisher: name: Università degli Studi di Roma "Tor Vergata"
Year: 2010
Subjects: subject: yap; nocodazole; phosphorylation; mitosis; apoptosis; Hippo; Lats2; cell cycle
subject: yap
subject: nocodazole
subject: phosphorylation
subject: mitosis
subject: apoptosis
subject: Hippo
subject: Lats2
subject: cell cycle

description: 22. ciclo
description: Yap - The protein identity card - What is the role of this protein? - Yap as a pro-apoptotic protein - Hippo pathway in Drosophila and Humans - The pathway is conserved along evolution: hippo pathway in mammals - Organ size - Oncogenetic function - Yap in mitosis - Regulation of mitosis - Proteins implicated in mitosis and related to Yap. - Experimental procedures - Cell culture - Plasmids and transfection - RNA interference - Synchronization and mitotic harvesting - Protein extraction and western blot analysis - Immunoprecipitation - Immunofluorescence - RNA extraction, reverse transcription, and PCR. - Introduction to the results. – Results - 1.1 The Hippo pathway Yap1 and Lats2 interact - 1.2 Lats2 and Mob1 cause phosphorylation of Yap1 - 2.1 Effects of nocodazole on PTM of Yap - 2.2 The shifted form of Yap is linked to mitosis - 2.3 The shift is caused by phosphorylation - 2.4 The phosphorylated form of Yap is present in many cell lines - 2.5 The phosphorylation is a physiological event - 2.6 Kinetics of phosphorylation - 2.7 Localization of the protein. - Discussion - References - Curriculum Vitae of the candidate
Rhipidomys emiliae
Creators: name: Lanes, Rayque De Oliveira
name: Bonvicino, Cibele Rodrigues
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Rhipidomys
Rhipidomys emiliae

description: Rhipidomys emiliae (J.A. Allen 1916)
Synonyms
Oecomys emiliae J. A. Allen, 1916 c:525; type locality “ Rio Mojú, Pará, Brazil.”
Oryzomys [(Oecomys)] emiliae: Ellerman, 1941:358; name combination.
Rhipidomys emiliae: Goodwin, 1953:306; first use of current name combination.
Holotype: AMNH 37495, subadult male, skin only; collected by E. Snethlage at “Rio Mojú, Pará, Brazil ” on 28 February 1914 (specimen ex Museu Paraense Emílio Goeldi, Belém).
Diagnosis: median sized Rhipidomys species (Total length ~ 275.75 mm; ONL ~ 32.61 mm), with brown to light orange dorsal pelage with cream venter. Tail (~ 144.5 mm) is longer than head-body length (HB~ 131.25 mm) and ends in a tuft. The feet are wide, with a blackish dorsal metatarsal stain in juveniles and a grayish color in adult specimens. The interorbital region is anteriorly convergent. The subsquamosal foramen is narrow and elongated in adults, the hamular process is long, and the post-glenoid foramen is large (elongated). Incisive foramen rounded on the sides, with a drop shape. Mesopterygoid fossa extends beyond the plane of third upper molar, the roof sphenopalatine vacuities that ranged from small slits to slightly larger openings. Posterolateral palatal pits of medium and small sizes at the edge of the mesopterygoid fossa (Fig. 2). In the mandible, the angular process ends in the same position of the end of condyloid process.
description: Published as part of Lanes, Rayque De Oliveira & Bonvicino, Cibele Rodrigues, 2023, Reevaluation of Rhipidomys emiliae (J. A. Allen 1916) and description of a new Rhipidomys (Rodentia: Cricetidae) species from Amazonia and Cerrado, pp. 581-597 in Zootaxa 5346 (5) on page 589, DOI: 10.11646/zootaxa.5346.5.5, http://zenodo.org/record/8390768
Additional file 2 of Age-dependent differences in the association between blood interleukin-6 levels and mortality in patients with sepsis: a retrospective observational study
Creators: name: Shimazui, Takashi
name: Oami, Takehiko
name: Shimada, Tadanaga
name: Tomita, Keisuke
name: Nakada, Taka-aki
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Mental Health

description: Additional file 2.
Additional file 1 of Comparative assessment of Mini-FLOTAC, McMaster and semi-quantitative flotation for helminth egg examination in camel faeces
Creators: name: Mohammedsalih, Khalid M.
name: Hassan, Salma A.
name: Juma, Fathel-Rahman
name: Saeed, Shamsaldeen I.
name: Bashar, Ahmed
name: von Samson-Himmelstjerna, Georg
name: Krücken, Jürgen
Publisher: name: figshare
Year: 2025
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 1.