cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 3 of An empirical evaluation of approximate and exact regression-based causal mediation approaches for a binary outcome and a continuous or a binary mediator for case-control study designs
Creators: name: Caubet, Miguel
name: L’Espérance, Kevin
name: Koushik, Anita
name: Lefebvre, Geneviève
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy
subject: Computational Biology

description: Additional file 3. Additional simulation results when n = 1000. We present the average regression parameters estimated using the studied strategies in our main simulations with n = 1000. We also present figures showing the impact of the misspecification of the prevalence parameter $$\pi$$ π on the performance of the exact and approximate approaches with IPW in the simulations with n = 1000.
The Engineering of Radioluminescent Nanoparticles as Therapeutic Agents for Multimodal Cancer Treatment
Creators: name: Pizzuti, Vincenzo J
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Chemical engineering not elsewhere classified

description: Under the guidance of cancer treatment data, this thesis emphasizes the development of radiation-responsive nanomaterials for the effective implementation of localized, multimodal therapy for solid tumors. Evidence from decades of treatment outcomes underscores the benefits provided by employing multiple therapeutic agents in concert to improve prognoses for cancer patients. As a pillar of standard care in oncology, radiation therapy (RT) is a particularly appropriate choice as a component of combination therapies, acting as a localized tool for achieving long-term tumor control. By combing primary RT with radio-sensitizing, polymer-encapsulated formulations of crystalline calcium tungstate nanoparticles (CWO NPs), this work has shown significant improvements in efficacy in in vitro and murine xenograft models of primary human head and neck tumors as well as in spontaneous sarcoma in a clinical case study. Under X-ray radiation, CWO NPs emit long-wavelength ultraviolet (UV-A) and visible light, a property referred to as radioluminescence. This work focuses on utilizing these properties in combination with encapsulant functionalization strategies to further improve therapeutic outcomes through specific mechanistic enhancements.
Ordinarily used primarily to improve biocompatibility and colloidal stability, the polymeric materials used to encapsulate the CWO NPs were tailored to serve distinct functions in the overall combination therapy scheme. Approaches explored in this work include surface functionalization of these polymers with a cancer-specific ligand, folic acid, and the incorporation of photo-responsive/sensitizing bilirubin-polymer conjugates as an encapsulant. The predicted outcomes of surface functionalization and photo-active encapsulation were confirmed to significantly enhance radiotherapy efficacy. Finally, exploration of intratumoral NP distribution after dose administration was conducted to preliminarily evaluate strategies for dose homogeneity improvement. Mechanical agitation of the injection site somewhat improves distribution of NPs in tumor xenografts but requires future exploration for improved understanding and implementation.
Two consecutive large outbreaks of Salmonella Muenchen linked to pig farming in Germany, 2013 to 2014: Is something missing in our regulatory framework?
Creators: name: Schielke, Anika
name: Rabsch, Wolfgang
name: Prager, Rita
name: Simon, Sandra
name: Fruth, Angelika
name: Helling, R.
name: Schnabel, M.
name: Siffczyk, C.
name: Wieczorek, S.
name: Schroeder, S.
name: Ahrens, B.
name: Oppermann, Hanna
name: Pfeiffer, S.
name: Merbecks, S. S.
name: Rosner, Bettina
name: Frank, Christina
name: Weiser, A. A.
name: Luber, P.
name: Gilsdorf, Andreas
name: Stark, Klaus
name: Werber, Dirk
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2017
Subjects: subject: 610 Medizin

description: In 2013, raw pork was the suspected vehicle of a large outbreak (n = 203 cases) of Salmonella Muenchen in the German federal state of Saxony. In 2014, we investigated an outbreak (n = 247 cases) caused by the same serovar affecting Saxony and three further federal states in the eastern part of Germany. Evidence from epidemiological, microbiological and trace-back investigations strongly implicated different raw pork products as outbreak vehicles. Trace-back analysis of S. Muenchen-contaminated raw pork sausages narrowed the possible source down to 54 pig farms, and S. Muenchen was detected in three of them, which traded animals with each other. One of these farms had already been the suspected source of the 2013 outbreak. S. Muenchen isolates from stool of patients in 2013 and 2014 as well as from food and environmental surface swabs of the three pig farms shared indistinguishable pulsed-field gel electrophoresis patterns. Our results indicate a common source of both outbreaks in the primary production of pigs. Current European regulations do not make provisions for Salmonella control measures on pig farms that have been involved in human disease outbreaks. In order to prevent future outbreaks, legislators should consider tightening regulations for Salmonella control in causative primary production settings.
Additional file 4 of An empirical evaluation of approximate and exact regression-based causal mediation approaches for a binary outcome and a continuous or a binary mediator for case-control study designs
Creators: name: Caubet, Miguel
name: L’Espérance, Kevin
name: Koushik, Anita
name: Lefebvre, Geneviève
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy
subject: Computational Biology

description: Additional file 4. Simulation results with n = 500. We present the natural effects estimates obtained with the studied mediation approaches with generated samples of size n = 500.
sj-docx-1-jnp-10.1177_23993693211031918 – Supplemental material for Identifying patients with CKD risk at the time of nephrectomy: When to initiate nephrology consult
Creators: name: Yang, Yihe
name: Kozel, Zachary
name: Sharma, Purva
name: Yaskiv, Oksana
name: Torres, Jose
name: Pandya, Shashank
name: Jhaveri, Kenar D.
name: Bhaskaran, Madhu
name: Vira, Manish
name: Bijol, Vanesa
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: FOS: Clinical medicine

description: Supplemental material, sj-docx-1-jnp-10.1177_23993693211031918 for Identifying patients with CKD risk at the time of nephrectomy: When to initiate nephrology consult by Yihe Yang, Zachary Kozel, Purva Sharma, Oksana Yaskiv, Jose Torres, Shashank Pandya, Kenar D. Jhaveri, Madhu Bhaskaran, Manish Vira and Vanesa Bijol in Journal of Onco-Nephrology
sj-pdf-1-cjk-10.1177_20543581211029722 – Supplemental material for Peritoneal Dialysis After Liver Transplantation: A Systematic Review
Creators: name: Côté, Jean Maxime
name: Ethier, Isabelle
name: Cardinal, Héloïse
name: Pépin, Marie-Noëlle
Publisher: name: SAGE Journals
Year: 2021
Subjects: Medicine

description: Supplemental material, sj-pdf-1-cjk-10.1177_20543581211029722 for Peritoneal Dialysis After Liver Transplantation: A Systematic Review by Jean Maxime Côté, Isabelle Ethier, Héloïse Cardinal and Marie-Noëlle Pépin in Canadian Journal of Kidney Health and Disease
Supplemental Material, sj-pdf-5-tva-10.1177_15248380211030502 - Population-Based Estimates of Associations Between Child Maltreatment Types: A Meta-Analysis
Creators: name: Matsumoto, Maya
name: Piersiak, Hannah A.
name: Letterie, Mia C.
name: Humphreys, Kathryn L.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law

description: Supplemental Material, sj-pdf-5-tva-10.1177_15248380211030502 for Population-Based Estimates of Associations Between Child Maltreatment Types: A Meta-Analysis by Maya Matsumoto, Hannah A. Piersiak, Mia C. Letterie and Kathryn L. Humphreys in Trauma, Violence, & Abuse
Prolonging calcineurin inhibitor therapy post kidney allograft failure: a prospective study
Creators: name: Leal, Rita
name: Fragoso, Pedro
name: Venda, João
name: Gomes, José
name: Inácio, Maria
name: Marques, Maria Guedes
name: Rodrigues, Luís
name: Santos, Lídia
name: Romãozinho, Catarina
name: Caramelo, Francisco
name: Sá, Helena Oliveira
name: Martinho, António
name: Figueiredo, Arnaldo
name: Alves, Rui
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: The optimal immunosuppressive (IS) withdrawal strategy after kidney allograft failure remains unclear. This study evaluated the effects of prolonged calcineurin inhibitor (CNI) therapy on HLA sensitization, graft intolerance syndrome (GIS), and key clinical outcomes. We conducted a prospective cohort study involving 90 adult patients with kidney allograft failure who were candidates for re-transplantation. Patients were divided into two groups: Rapid withdrawal group (discontinuation of all IS except low-dose prednisolone) and Prolonged CNI Group (maintenance of CNI for six months plus low-dose prednisolone). Outcomes assessed over a 12-month follow-up period included HLA sensitization, defined as an increase in calculated panel reactive antibody (cPRA) and the development of de novo donor-specific antibodies (dnDSA), GIS incidence, re-transplantation, hospitalization rates, and mortality. No significant differences were observed between the groups regarding HLA sensitization one-year postgraft failure. A composite outcome of cPRA increase, dnDSA, and GIS did not differ between the groups. When evaluated separately, GIS occurred less frequently in the Prolonged CNI Group (4.8% vs. 23%; p = 0.015). Patients who continued CNI maintained better residual kidney function at 6 months (800 vs. 200 mL, p = 0.001) and experienced lower all-cause hospitalization rates (12% vs. 30%, p = 0.036), with comparable retransplantation and mortality rates. Graft removal and higher HLA mismatches were independently linked to increased sensitization at 12 months. Prolonged CNI therapy for six months postallograft loss did not prevent HLA sensitization but reduced the incidence of GIS and preserved residual kidney function without increasing hospitalization or mortality.
Additional file 5 of An empirical evaluation of approximate and exact regression-based causal mediation approaches for a binary outcome and a continuous or a binary mediator for case-control study designs
Creators: name: Caubet, Miguel
name: L’Espérance, Kevin
name: Koushik, Anita
name: Lefebvre, Geneviève
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy
subject: Computational Biology

description: Additional file 5. Additional results for the real-data analysis. We present mediation analysis results based on the data from the PROVAQ study, including the estimated mediator and outcome models for the main analysis as well as results corresponding to the simpler outcome model which omits the interaction term between the exposure and mediator.
Supplemental Material, sj-pdf-9-tva-10.1177_15248380211030502 - Population-Based Estimates of Associations Between Child Maltreatment Types: A Meta-Analysis
Creators: name: Matsumoto, Maya
name: Piersiak, Hannah A.
name: Letterie, Mia C.
name: Humphreys, Kathryn L.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law

description: Supplemental Material, sj-pdf-9-tva-10.1177_15248380211030502 for Population-Based Estimates of Associations Between Child Maltreatment Types: A Meta-Analysis by Maya Matsumoto, Hannah A. Piersiak, Mia C. Letterie and Kathryn L. Humphreys in Trauma, Violence, & Abuse
Viral genetic variation accounts for a third of variability in HIV-1 set-point viral load in Europe
Creators: name: Blanquart, François
name: Wymant, Chris
name: Cornelissen, Marion
name: Gall, Astrid
name: Bakker, Margreet
name: Bezemer, Daniela
name: Hall, Matthew
name: Hillebregt, Mariska
name: Ong, Swee Hoe
name: Albert, Jan
name: Bannert, Norbert
name: Fellay, Jacques
name: Fransen, Katrien
name: Gourlay, Annabelle J.
name: Grabowski, M. Kate
name: Gunsenheimer-Bartmeyer, Barbara
name: Günthard, Huldrych F.
name: Kivelä, Pia
name: Kouyos, Roger
name: Laeyendecker, Oliver
name: Liitsola, Kirsi
name: Meyer, Laurence
name: Porter, Kholoud
name: Ristola, Matti
name: Sighem, Ard Van
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2017
Subjects: subject: 610 Medizin

description: HIV-1 set-point viral load—the approximately stable value of viraemia in the first years of chronic infection—is a strong predictor of clinical outcome and is highly variable across infected individuals. To better understand HIV-1 pathogenesis and the evolution of the viral population, we must quantify the heritability of set-point viral load, which is the fraction of variation in this phenotype attributable to viral genetic variation. However, current estimates of heritability vary widely, from 6% to 59%. Here we used a dataset of 2,028 seroconverters infected between 1985 and 2013 from 5 European countries (Belgium, Switzerland, France, the Netherlands and the United Kingdom) and estimated the heritability of set-point viral load at 31% (CI 15%–43%). Specifically, heritability was measured using models of character evolution describing how viral load evolves on the phylogeny of whole-genome viral sequences. In contrast to previous studies, (i) we measured viral loads using standardized assays on a sample collected in a strict time window of 6 to 24 months after infection, from which the viral genome was also sequenced; (ii) we compared 2 models of character evolution, the classical “Brownian motion” model and another model (“Ornstein–Uhlenbeck”) that includes stabilising selection on viral load; (iii) we controlled for covariates, including age and sex, which may inflate estimates of heritability; and (iv) we developed a goodness of fit test based on the correlation of viral loads in cherries of the phylogenetic tree, showing that both models of character evolution fit the data well. An overall heritability of 31% (CI 15%–43%) is consistent with other studies based on regression of viral load in donor–recipient pairs. Thus, about a third of variation in HIV-1 virulence is attributable to viral genetic variation.
Spectral Properties and Generation of Realistic Networks
Creators: name: Eikmeier, Nicole E
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Theory of computation not elsewhere classified
Applied mathematics not elsewhere classified

description: Picture the life of a modern person in the western world: They wake up in the morning and check their social networking sites; they drive to work on roads that connect cities to each other; they make phone calls, send emails and messages to colleagues, friends, and family around the world; they use electricity flowing through power-lines; they browse the Internet, searching for information. All of these typical daily activities rely on the structure of networks. A network, in this case, is a set of nodes (people, web pages, etc) connected by edges (physical connection, collaboration, etc). The term graph is sometimes used to represent a more abstract structure - but here we use the terms graph and network interchangeably. The field of network analysis concerns studying and understanding networks in order to solve problems in the world around us. Graph models are used in conjunction with the study of real-world networks. They are used to study how well an algorithm may do on a real-world network, and for testing properties that may further produce faster algorithms. The first piece of this dissertation is an experimental study which explores features of real data, specifically power-law distributions in degrees and spectra. In addition to a comparison between features of real data to existing results in the literature, this study resulted in a hypothesis on power-law structure in spectra of real-world networks being more reliable than that in the degrees. The theoretical contributions of this dissertation are focused primarily on generating realistic networks through existing and novel graph models. The two graph models presented are called HyperKron and the Triangle Generalized Preferential Attachment model. Both of the models incorporate higher-order structure - leading to more sophisticated properties not examined in traditional models. We use the second of our models to further validate the hypothesis on power-laws in the spectra. Due to the structure of our model, we show that the power-law in the spectra is more resilient to sub-sampling. This gives some explanation for why we see power-laws more frequently in the spectra in real world data.
Letter to the editor: “Association of Geriatric Nutritional Risk Index with short-term mortality in patients with severe acute kidney injury: retrospective cohort study”
Creators: name: Pais, Mariana Dias
name: Coelho, Sílvia
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Hematology
subject: Computational Biology

description: Letter to the editor: “Association of Geriatric Nutritional Risk Index with short-term mortality in patients with severe acute kidney injury: retrospective cohort study”
Fruit consumption among adults in Germany
Creators: name: Mensink, Gert
name: Schienkiewitz, Anja
name: Lange, Cornelia
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2017
Subjects: subject: ADULTS
subject: GERMANY
subject: HEALTH MONITORING
subject: FRUIT
subject: INTERVIEW SURVEY
subject: 610 Medizin

description: Eating fruit is part of a healthy diet and can help prevent various chronic diseases. According to GEDA 2014/2015- EHIS data, 54.2% of women and 38.1% of men eat fruit daily. 38.0% of women and 25.5% of men aged 18 to 29 years eat fruit daily; and in the age group of 65 and older this figure rises to 72.6% for women and 61.1% for men. In the age groups under 65, women with higher levels of education are more likely to eat fruit every day, for men this correlation applies only to those aged between 45 and 64. In Brandenburg, Mecklenburg-West Pomerania, Saxony, Saxony-Anhalt and Thuringia, the proportion of women and men who eat fruit daily is higher than the German average, and in Bavaria and Saarland the proportion of men who eat fruit daily is lower than the German average.
Community-Led Design: A Framework for Writing and Designing with Community Partners
Creators: name: Knight, Aimee
Publisher: name: Humanities Commons
Year: 2022
Subjects: subject: Service learning
subject: Teaching
subject: Equity
subject: Inclusive education
subject: Design

description: WHAT IS COMMUNITY-LED DESIGN?  Community-led design is a grassroots approach to community-university research partnerships. It provides practitioners with a roadmap for implementation that centers community-driven change. This flexible framework focuses on a collaborative practice of iterating, making, and testing that puts the community first. The community-led design framework represents a commitment toward more equitable, inclusive, and justice-oriented design processes. It recognizes that every successful design lies within the heart of the community it serves.
Parents with mental health problems and their children in a German population based sample: Results of the BELLA study
Creators: name: Plass-Christl, Angela
name: Haller, Anne-Catherine
name: Otto, Christiane
name: Barkmann, Claus
name: Wiegand-Grefe, Silke
name: Hölling, Heike
name: Schulte-Markwort, Michael
name: Ravens-Sieberer, Ulrike
name: Klasen, Fionna
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2017
Subjects: subject: 610 Medizin

description: Background: Mental health problems (MHP) of parents are associated with an increased risk of psychological and developmental difficulties in their children. This study aims at analyzing population-based data of parents with MHP and their children and the effects of associated risk factors in order to further targeted preventive and therapeutic interventions. Methods: The BELLA study is the mental health module of the German National Health Interview and Examination Survey among Children and Adolescents. MHP in parents and in their children as well as associated risk factors were examined in a sample of N = 1158 parents with children aged 11 to 17 years. Results: Parental MHP were identified in 18.6% of the sample. Risk factors associated with parental MHP were low SES, parental unemployment, stressful life events, parental daily strain, parental chronic disease, and child MHP. A rate of 19.1% of the children of parents with MHP reported MHP themselves, the corresponding rate among children of parents without MHP was 7.7%. In multiple regression analyses the risk for children of parents with MHP to report MHP themselves was almost two times higher than the risk of children of parents without MHP. Other significant associations with child MHP included gender, the parents’ age, and stressful life events. Conclusions: Parental MHP constitute a significant risk for the mental health of their children. Targeted screening methods and preventive interventions are needed.
Community-Led Design: A Framework for Writing and Designing with Community Partners
Creators: name: Knight, Aimee
Publisher: name: unknown
Year: 2022
Subjects: subject: Teaching
subject: Equity
subject: Service learning
subject: Inclusive education
subject: Design

description: WHAT IS COMMUNITY-LED DESIGN?
Community-led design is a grassroots approach to community-university research partnerships. It provides practitioners with a roadmap for implementation that centers community-driven change. This flexible framework focuses on a collaborative practice of iterating, making, and testing that puts the community first. The community-led design framework represents a commitment toward more equitable, inclusive, and justice-oriented design processes. It recognizes that every successful design lies within the heart of the community it serves.
Bericht zur gesundheitlichen Lage der Männer in Deutschland – Fazit und Herausforderungen für eine gendersensible Gesundheitsberichterstattung
Creators: name: Starker, Anne
name: Rommel, Alexander
name: Saß, Anke-Christine
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2016
Subjects: subject: Daten
subject: Männergesundheit
subject: Gesundheitsbericht
subject: Gendersensible Gesundheitsberichterstattung
subject: Forschung
subject: 610 Medizin

description: Im Dezember 2014 erschien der „Bericht zur gesundheitlichen Lage der Männer in Deutschland“ im Rahmen der Gesundheitsberichterstattung des Bundes (GBE). Er deckt ein breites Themenspektrum ab, von Erkrankungen und Todesursachen über das Gesundheitsverhalten bis zu männerspezifischer Prävention. Fokuskapitel widmen sich dem Einfluss von Arbeit und Lebensformen auf die Gesundheit. Auf der Grundlage methodischer Vorarbeiten zu geschlechtersensibler GBE wurde für die Berichterstellung ein mehrstufiges Verfahren angestrebt: Über eine geschlechtervergleichende Perspektive hinaus sollten innerhalb der Gruppe der Männer Unterschiede hinsichtlich Belastungen, Risiken und Ressourcen thematisiert werden und die Ergebnisse vor dem Hintergrund politischer und gesellschaftlicher Rahmenbedingungen eingeordnet sowie theoriegeleitet interpretiert werden. Das Projektteam des Männergesundheitsberichtes wirft im vorliegenden Artikel einen kritischen Blick auf seine Arbeit: Welche Schritte auf dem Weg zu einer geschlechtersensiblen GBE konnten im Bericht realisiert werden? Und wo besteht weiterhin Handlungsbedarf? Denn geschlechtersensible GBE kann dazu beitragen, die gesundheitliche Situation von Männern und Frauen besser zu beschreiben und damit eine solide empirische Grundlage für die Umsetzung einer geschlechtergerechten Gesundheitsversorgung liefern.
Reduced efficacy of albendazole against Ascaris lumbricoides in Rwandan schoolchildren
Creators: name: Krücken, Jürgen
name: Fraundorfer, Kira
name: Mugisha, Jean Claude
name: Ramünke, Sabrina
name: Sifft, Kevin C.
name: Geus, Dominik
name: Habarugira, Felix
name: Ndoli, Jules
name: Sendegeya, Augustin
name: Mukampunga, Caritas
name: Bayingana, Claude
name: Aebischer, Toni
name: Demeler, Janina
name: Gahutu, Jean Bosco
name: Mockenhaupt, Frank P.
name: Samson-Himmelstjerna, Georg Von
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2017
Subjects: subject: Resistance
subject: Soil-transmitted helminth
subject: Benzimidazole
subject: Albendazole
subject: Ascaris
subject: Deworming
subject: Tubulin
subject: 610 Medizin

description: Control of human soil-transmitted helminths (STHs) relies on preventive chemotherapy of schoolchildren applying the benzimidazoles (BZ) albendazole or mebendazole. Anthelmintic resistance (AR) is a common problem in nematodes of veterinary importance but for human STHs, information on drug efficacy is limited and routine monitoring is rarely implemented. Herein, the efficacy of single dose albendazole (400 mg) was evaluated in 12 schools in the Huye district of Rwanda where Ascaris is the predominant STH. Ascaris eggs were detected by wet mount microscopy and the Mini-FLOTAC method to assess cure rate (CR) and faecal egg count reduction (FECR). Blood and faecal samples were analysed for co-infections with Plasmodium sp. and Giardia duodenalis, respectively. Ascaris positive samples collected before and after treatment were analysed for putatively BZ-resistance associated β-tubulin gene single nucleotide polymorphisms. The overall CR was 69.9% by Mini-FLOTAC and 88.6% by wet mount microscopy. The FECR was 75.4% and the 95% calculated confidence intervals were 50.4–87.8% using sample variance, 55.4–88.8% by bootstrapping, and 75.0–75.7% applying a Markov Chain Monte Carlo Bayesian approach. FECR varied widely between 0 and 96.8% for individual schools. No putative BZ-resistance associated polymorphisms were found in the four Ascaris β-tubulin isotype genes examined. Since FECRs
Additional file 1 of Renal damage and old age: risk factors for thrombosis in patients with ANCA-associated vasculitis
Creators: name: Chen, Xin
name: Zhang, Shuo
name: You, Ruilian
name: Ma, Yixin
name: Xia, Peng
name: Shi, Xiaoxiao
name: Wu, Haiting
name: Zheng, Ke
name: Qin, Yan
name: Tian, Xinping
name: Chen, Limeng
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy
subject: Hematology

description: Supplementary Material 1: sFigure 1. Calibration curves of the predicted nomogram. The x-axis represents the predicted probability calculated by the nomogram, and the y-axis is the observed actual probability of thrombotic events in AAV patients. Results of the Hosmer-Lemeshow test demonstrate that the P-value of 0.541. sFigure 2. The decision curve analysis (DCA) of the nomogram. The horizontal line indicates no AAV patients with thrombosis, and the red diagonal line indicates AAV patients with thrombosis. The solid blue line indicates the risk nomogram. In DCA, the nomogram shows more net benefit THAN full or no treatment across a threshold probability range. sTable 1. The rate of thrombosis in different AAV classifications. sTable 2. The clinical characteristics between thrombosis and non-thrombosis in MPA. sTable 3. The clinical characteristics between thrombosis and non-thrombosis in GPA. sTable 4. The clinical characteristics between thrombosis and non-thrombosis in EGPA.
Association between lipid-lowering drug targets and the risk of cystic kidney disease: a drug-target Mendelian randomization analysis
Creators: name: Lian, Zhiwen
name: Liang, Zijie
name: Chen, Qiyan
name: Xie, Chao
name: Kong, Yaozhong
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer
subject: Science Policy

description: Evidence regarding the causal relationship between lipid-lowering drugs and cystic kidney disease, including polycystic kidney disease (PKD), was limited. This study aimed to evaluate the causal relationship between lipid phenotypes mediated by lipid-lowering drug targets—3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMGCR), proprotein convertase subtilisin/kexin type-9 (PCSK9), and Niemann-Pick C1-like 1 (NPC1L1)—and the risk of cystic kidney disease and PKD. Genetic variants encoding lipid-lowering drug targets—HMGCR, PCSK9, and NPC1L1—from published genome-wide association study (GWAS) statistics were collected to perform drug target Mendelian randomization (MR) analysis. Summary statistics for the GWAS of cystic kidney disease and PKD were obtained from the FinnGen consortium and the European Bioinformatics Institute. Inverse variance weighting (IVW) was used as the primary MR analysis method, with sensitivity analyses conducted to ensure the robustness of the results. Increased gene expression of HMGCR was associated with an elevated risk of cystic kidney disease (IVW-MR: odds ratio [OR] = 3.05, 95% confidence interval [CI] = 1.19–7.84, p = 0.02) and PKD (IVW-MR: OR = 2.13, 95% CI = 1.01–4.46; p = 0.045). There was no evidence of causal effects of PCSK9 and NPC1L1 targets on cystic kidney disease and PKD. Cochran’s Q test, MR-PRESSO, and MR-Egger intercept tests showed no heterogeneity or horizontal pleiotropy among the instrumental variables. This study supported that increased HMGCR expression was associated with an increased risk of cystic kidney disease and PKD, suggesting potential benefits of statin therapy for cystic kidney disease and PKD. Further research is necessary to elucidate specific mechanisms and potential therapeutic applications of HMGCR inhibitors.
Comprehensive assessment of food and nutrient intake of children and adolescents in Germany: EsKiMo II – the eating study as a KiGGS module
Creators: name: Barbosa, Clarissa Lage
name: Brettschneider, Anna-Kristin
name: Haftenberger, Marjolein
name: Lehmann, Franziska
name: Frank, Melanie
name: Heide, Karoline
name: Patelakis, Eleni
name: Perlitz, Hanna
name: Krause, Laura
name: Houben, Robin
name: Butschalowsky, Hans
name: Richter, Almut
name: Kamtsiuris, Panagiotis
name: Mensink, Gert
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2017
Subjects: subject: Germany
subject: EsKiMo
subject: Children and adolescents
subject: Nutrition
subject: Food and nutrient intake
subject: Dietary behavior
subject: 610 Medizin

description: Background: As part of the second wave of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS Wave 2), food and nutrient intake of children and adolescents aged 6–17 years living in Germany is assessed in EsKiMo II – the Eating Study as a KiGGS Module. Methods: EsKiMo II is a cross-sectional study, conducted from June 2015 until September 2017. The study population comprises 6 to 17-year-old study participants from the cross-sectional sample of KiGGS Wave 2 in 167 KiGGS sample points, which are revisited by trained nutritionists. Dietary intake is assessed by weighted food records during three consecutive days plus one randomly selected day within the following 3 months for children aged 6–11 years. Dietary intake for adolescents aged 12–17 years is assessed by computer-assisted dietary history interviews, reflecting the past four weeks, using the software DISHES. Further information, for example, about specific diets and dietary supplement intake, is reported during a standardised computer assisted interview for all participants. Food items are coded by the German Food Code and Nutrient Database (BLS 3.02). Discussion: EsKiMo II provides actual data on the dietary behaviour of children and adolescents living in Germany and their determinants. Results of EsKiMo II will be relevant for decision-making, measures, and evaluations within nutrition, consumer and health policy.
sj-docx-1-tan-10.1177_17562864211030664 – Supplemental material for Predicting conversion to multiple sclerosis in patients with radiologically isolated syndrome: a retrospective study
Creators: name: Chaloulos-Iakovidis, Panagiotis
name: Wagner, Franca
name: Weber, Lea
name: Diem, Lara
name: Chan, Andrew
name: Salmen, Anke
name: Friedli, Christoph
name: Hoepner, Robert
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified

description: Supplemental material, sj-docx-1-tan-10.1177_17562864211030664 for Predicting conversion to multiple sclerosis in patients with radiologically isolated syndrome: a retrospective study by Panagiotis Chaloulos-Iakovidis, Franca Wagner, Lea Weber, Lara Diem, Andrew Chan, Anke Salmen, Christoph Friedli and Robert Hoepner in Therapeutic Advances in Neurological Disorders
sj-pdf-1-tar-10.1177_17534666211028072 – Supplemental material for LncRNA CASC2 is involved in the development of chronic obstructive pulmonary disease via targeting miR-18a-5p/IGF1 axis
Creators: name: Liu, Panpan
name: Zhang, Huali
name: Zeng, Haizhu
name: Meng, Yingxia
name: Gao, Hongchang
name: Zhang, Meilan
name: Zhao, Lei
Publisher: name: SAGE Journals
Year: 2021
Subjects: Aged Health Care
Pharmacology and Pharmaceutical Sciences not elsewhere classified
Respiratory Diseases

description: Supplemental material, sj-pdf-1-tar-10.1177_17534666211028072 for LncRNA CASC2 is involved in the development of chronic obstructive pulmonary disease via targeting miR-18a-5p/IGF1 axis by Panpan Liu, Huali Zhang, Haizhu Zeng, Yingxia Meng, Hongchang Gao, Meilan Zhang and Lei Zhao in Therapeutic Advances in Respiratory Disease
Supplemental Material, sj-pdf-1-psm-10.1177_14613557211026938 - Policing and collective efficacy: A rapid evidence assessment
Creators: name: Yesberg, Julia Anne
name: Bradford, Ben
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law

description: Supplemental Material, sj-pdf-1-psm-10.1177_14613557211026938 for Policing and collective efficacy: A rapid evidence assessment by Julia Anne Yesberg and Ben Bradford in International Journal of Police Science & Management
The zoonotic potential of Clostridium difficile from small companion animals and their owners
Creators: name: Rabold, Denise
name: Espelage, Werner
name: Sin, Muna Abu
name: Eckmanns, Tim
name: Schneeberg, Alexander
name: Neubauer, Heinrich
name: Möbius, Nadine
name: Hille, Katja
name: Wieler, Lothar H.
name: Seyboldt, Christian
name: Lübke-Becker, Antina
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2018
Subjects: subject: 610 Medizin

description: Background: Clostridium difficile infections (CDI) in humans range from asymptomatic carriage to life-threatening intestinal disease. Findings on C. difficile in various animal species and an overlap in ribotypes (RTs) suggest potential zoonotic transmission. However, the impact of animals for human CDI remains unclear. Methods: In a large-scale survey we collected 1,447 fecal samples to determine the occurrence of C. difficile in small companion animals (dogs and cats) and their owners and to assess potential epidemiological links within the community. The Germany-wide survey was conducted from July 2012-August 2013. PCR ribotyping, Multilocus VNTR Analysis (MLVA) and PCR detection of toxin genes were used to characterize isolated C. difficile strains. A database was defined and logistic regression used to identify putative factors associated with fecal shedding of C. difficile. Results: In total, 1,418 samples met the inclusion criteria. The isolation rates for small companion animals and their owners within the community were similarly low with 3.0% (25/840) and 2.9% (17/578), respectively. PCR ribotyping revealed eight and twelve different RTs in animals and humans, respectively, whereas three RTs were isolated in both, humans and animals. RT 014/0, a well-known human hospital-associated lineage, was predominantly detected in animal samples. Moreover, the potentially highly pathogenic RTs 027 and 078 were isolated from dogs. Even though, C. difficile did not occur simultaneously in animals and humans sharing the same household. The results of the epidemiological analysis of factors associated with fecal shedding of C. difficile support the hypothesis of a zoonotic potential. Conclusions: Molecular characterization and epidemiological analysis revealed that the zoonotic risk for C. difficile associated with dogs and cats within the community is low but cannot be excluded.
CHARACTERIZATION OF INKJET PRINTED HIGH NITROGEN ENERGETIC MATERIALS AND BILAYER NANOTHERMITE
Creators: name: Patra, Adarsh
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Chemical thermodynamics and energetics
Aerospace engineering not elsewhere classified
Mechanical engineering not elsewhere classified

description: This thesis presents work on two major areas of research. The first area of research involves the use of a dual-nozzle piezoelectric inkjet printing system to print bilayer aluminum bismuth (III) oxide nanothermite samples. The combinatorial printing method allows for separate fuel and oxidizer inks to be printed adjacent to each other at prescribed offset distances. The effect of the bilayer thickness on the burning rate of the samples is investigated using high-speed imaging. Analysis of the burning rate data revealed that there is no statistically significant relationship between these two parameters. This result was used to determine the dominant processes that control the propagation rate in nanothermite systems. It was concluded that convective processes dominate the burning rate rather than diffusive processes. The second area of research involved synthesizing inks suitable for inkjet printing using two promising high nitrogen energetic materials called BTATz and DAATO3.5. The performance of the developed inks was characterized using four experiments. The thermal stability and exothermic behavior of the inks were determined using DSC and TGA analysis. The results revealed that the inks are more thermally stable than the base materials. The inks were used to print lines that were subsequently used to determine burning rates. DAATO3.5 samples were determined to have faster burning rates than BTATz. Closed pressure bomb experiments were conducted to determine the gas producing capability of the high nitrogen inks. BTATz samples showed better performance in terms of peak static pressures and pressurization rates. 3D printed microthrusters were developed to test the thrust performance of the inks. Peak thrust, total impulse, and specific impulse values are reported and were determined to be suitable for use with Class 1 micro-spacecraft. Finally, a microthruster array prototype was developed to demonstrate the capability to use additive manufacturing to create high packing density arrays.
Impfquoten bei der Schuleingangsuntersuchung in Deutschland 2016
Creators: name: Koch-Institut, Robert
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2018
Subjects: subject: 610 Medizin

description: Anlässlich der 13. Europäischen Impfwoche der Weltgesundheitsorganisation (WHO), Regionalbüro Europa, die vom 23. – 29. April 2018 stattfindet, berichten wir über die Impfquoten bei den Schulanfängern in Deutschland. Die Impfquoten sind in den letzten Jahren kontinuierlich gestiegen bzw. konstant hoch geblieben. Die Quoten der lange etablierten Kinder-Standardimpfungen bewegen sich überwiegend auf hohem Niveau. Erstmals erreichen alle Bundesländer eine Impfquote von mindestens 95 % für die erste Impfung gegen Masern, Mumps und Röteln. Dennoch besteht weiterhin Verbesserungsbedarf hinsichtlich der zweiten Impfung. Für Impfungen, die erst in den letzten zirka zehn Jahren eingeführt wurden, sollten die Impfquoten weiterhin verbessert werden. Repräsentative Impfdaten, wie sie in den Schuleingangsuntersuchungen erhoben werden, sind ein unverzichtbarer Bestandteil für die Beurteilung der gesundheitlichen Gefährdung durch Infektionskrankheiten. Zugleich geben sie wichtige Hinweise zur Effektivität von Impfprogrammen und zur Impfakzeptanz und lassen bestehende Impflücken erkennen.
Structural Insights into Phospholipase Cε Function
Creators: name: Rugema, Ngango Yvon
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Biochemistry and cell biology not elsewhere classified

description: Phospholipase Cε (PLCε) is a member of the PLC family of enzymes, which hydrolyze phosphatidylinositol lipids following the activation of G protein coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs). PLCε is unique among the PLC superfamily as it contains an N-terminal CDC25 domain, which has a guanine nucleotide exchange factor (GEF) activity for the small G protein Rap1A, and two C-terminal Ras association (RA) domains that bind scaffolding proteins and activated G proteins. PLCε activity plays an important role in cardiomyocyte contractility and survival. The best-characterized pathway of PLCε activation is mediated by β-adrenergic (β-AR) receptors. Stimulation of these receptors culminates in the activation of the small GTPase Rap1A, which binds to PLCε at the sarcoplasmic reticulum. There, PLCε hydrolyzes phosphatidylinol-4-phosphate (PI4P) to produce diacylglycerol (DAG). Prolonged activation of this pathway results in increased Ca2+-induced Ca2+ release (CICR) and increased expression of hypertrophy-related genes. However, the structural basis of PLCε basal activity, and the mechanism of Rap1A activation are largely unknown. We have now obtained the first high-resolution structure of PLCε. These studies, together with biochemical validation of our structure-based hypotheses, provide the first molecular insights into this enzyme.
sj-pdf-1-tar-10.1177_17534666211016071 – Supplemental material for The perplexing role of RAGE in pulmonary fibrosis: causality or casualty?
Creators: name: Perkins, Timothy N.
name: Oury, Tim D.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine
subject: 110203 Respiratory Diseases

description: Supplemental material, sj-pdf-1-tar-10.1177_17534666211016071 for The perplexing role of RAGE in pulmonary fibrosis: causality or casualty? by Timothy N. Perkins and Tim D. Oury in Therapeutic Advances in Respiratory Disease
Supplemental Material, sj-pdf-4-tva-10.1177_15248380211030502 - Population-Based Estimates of Associations Between Child Maltreatment Types: A Meta-Analysis
Creators: name: Matsumoto, Maya
name: Piersiak, Hannah A.
name: Letterie, Mia C.
name: Humphreys, Kathryn L.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law

description: Supplemental Material, sj-pdf-4-tva-10.1177_15248380211030502 for Population-Based Estimates of Associations Between Child Maltreatment Types: A Meta-Analysis by Maya Matsumoto, Hannah A. Piersiak, Mia C. Letterie and Kathryn L. Humphreys in Trauma, Violence, & Abuse
Rapid Viral Diagnosis of Orthopoxviruses by Electron Microscopy: Optional or a Must?
Creators: name: Gelderblom, Hans R.
name: Madeley, Dick
Publisher: name: Robert Koch-Institut, Biologische Sicherheit
Year: 2018
Subjects: subject: negative staining
subject: diagnostic electron microscopy (DEM)
subject: rapid viral diagnosis
subject: febrile vesicular rashes
subject: skin lesions
subject: orthopoxviruses (OPV)
subject: parapoxviruses (PPV)
subject: herpesviruses (HSV
subject: VZV)
subject: 610 Medizin

description: Diagnostic electron microscopy (DEM) was an essential component of viral diagnosis until the development of highly sensitive nucleic acid amplification techniques (NAT). The simple negative staining technique of DEM was applied widely to smallpox diagnosis until the world-wide eradication of the human-specific pathogen in 1980. Since then, the threat of smallpox re-emerging through laboratory escape, molecular manipulation, synthetic biology or bioterrorism has not totally disappeared and would be a major problem in an unvaccinated population. Other animal poxviruses may also emerge as human pathogens. With its rapid results (only a few minutes after arrival of the specimen), no requirement for specific reagents and its “open view”, DEM remains an important component of virus diagnosis, particularly because it can easily and reliably distinguish smallpox virus or any other member of the orthopoxvirus (OPV) genus from parapoxviruses (PPV) and the far more common and less serious herpesviruses (herpes simplex and varicella zoster). Preparation, enrichment, examination, internal standards and suitable organisations are discussed to make clear its continuing value as a diagnostic technique.
Supplemental Material, sj-pdf-2-tct-10.1177_15330338211033077 - EMT Participates in the Regulation of Exosomes Secretion and Function in Esophageal Cancer Cells
Creators: name: Chen, Chuangui
name: Ma, Zhao
name: Jiang, Hongjing
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: FOS: Clinical medicine
subject: 110320 Radiology and Organ Imaging
subject: Biochemistry

description: Supplemental Material, sj-pdf-2-tct-10.1177_15330338211033077 for EMT Participates in the Regulation of Exosomes Secretion and Function in Esophageal Cancer Cells by Chuangui Chen, Zhao Ma and Hongjing Jiang in Technology in Cancer Research & Treatment