Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
Creators: name: Mägi, Reedik
name: Dedoussis, George
name: Ohlsson, Therese
name: Frossard, Philippe
name: Scott, Robert A.
name: Komulainen, Pirjo
name: Warren, Helen
name: Nelson, Christopher P.
name: Lind, Lars
name: Kuusisto, Johanna
name: Holmen, Oddgeir Lingaas
name: Langenberg, Claudia
name: Swift, Amy J.
name: Herzig, Karl-Heinz
name: Burgess, Stephen
name: Alam, Dewan S.
name: Moayyeri, Alireza
name: Traylor, Matthew
name: Cook, James P.
name: Verweij, Niek
name: Young, Robin
name: Franks, Steve
name: Trompet, Stella
name: Van Der Meer, Peter
name: Gambaro, Giovanni
name: Linneberg, Allan
name: Boehnke, Michael
name: Lakka, Timo A.
name: Stančáková, Alena
name: Surendran, Praveen
name: Malerba, Giovanni
name: Oksa, Heikki
name: Padmanabhan, Sandosh
name: Howson, Joanna M. M.
name: Butterworth, Adam S.
name: Zhang, He
name: Hansen, Torben
name: Karpe, Fredrik
name: De Boer, Rudolf A.
name: Kathiresan, Sekar
name: Poveda, Alaitz
name: Collins, Francis S.
name: Tuomilehto, Jaakko
name: Veronesi, Giovanni
name: Tukiainen, Taru
name: Lin, Honghuang
name: Majumder, Abdulla Al Shafi
name: Hallmans, Göran
name: Groop, Leif
name: Morris, Andrew D.
name: Rudan, Igor
name: Varga, Tibor V
name: Brown, Morris J.
name: Zeggini, Eleftheria
name: Mohlke, Karen L.
name: Käräjämäki, Annemari
name: Christensen, Cramer
name: Huyghe, Jeroen R.
name: Hoek, Maarten
name: Pedersen, Oluf
name: Donnelly, Louise A.
name: Harris, Sarah E.
name: Yiorkas, Andrianos M.
name: Deloukas, Panos
name: Thuesen, Betina
name: Ford, Ian
name: Rauramaa, Rainer
name: Lindström, Jaana
name: Zhang, Weihua
name: Trabetti, Elisabetta
name: Vasan, Ramachandran S.
name: Reilly, Dermot F.
name: Nielsen, Sune Fallgaard
name: Deary, Ian J.
name: Metspalu, Andres
name: Stirrups, Kathleen E.
name: Witkowska, Kate
name: Perola, Markus
name: Palotie, Aarno
name: Tinker, Andrew
name: Amouyel, Philippe
name: Masca, Nicholas
name: Nordestgaard, Børge Grønne
name: Staley, James R.
name: Ferreira, Teresa
name: Tuomi, Tiinamaija
name: Matchan, Angela
name: Hayward, Caroline
name: Marten, Jonathan
name: Chowdhury, Rajiv
name: Samuel, Maria
name: Markus, Hugh S.
name: Kooner, Jaspal S.
name: Farmaki, Aliki-Eleni
name: Wareham, Nick J.
name: Kee, Frank
name: Southam, Lorraine
name: McCarthy, Mark I.
name: Sever, Peter
name: Mahajan, Anubha
name: Starr, John M.
name: Rasheed, Asif
name: Marioni, Riccardo
name: Gjesing, Anette P.
name: Manning, Alisa K.
name: Liu, Chunyu
name: Ferrières, Jean
name: Kontto, Jukka
name: Stringham, Heather M.
name: Morris, Andrew P.
name: Newton-Cheh, Christopher
name: Korpi-Hyövälti, Eeva
name: Doney, Alex S. F.
name: Laakso, Markku
name: Fava, Cristiano
name: Uria-Nickelsen, Maria
name: Palmer, Colin N. A.
name: Arveiler, Dominique
name: Ripatti, Samuli
name: Connell, John M.
name: Narisu, Narisu
name: Willer, Cristen J.
name: Evangelou, Evangelos
name: Renström, Frida
name: Liewald, David C. M.
name: Sim, Xueling
name: Menni, Cristina
name: Felix, Janine F.
name: Jarvelin, Marjo-Riitta
name: Giannakopoulou, Olga
name: Mihailov, Evelin
name: Sattar, Naveed
name: Tobin, Martin D.
name: Salomaa, Veikko
name: Wain, Louise V.
name: Lieb, Wolfgang
name: Highland, Heather M.
name: Saleheen, Danish
name: Di Angelantonio, Emanuele
name: Kajantie, Eero
name: Blakemore, Alexandra I. F.
name: Virtamo, Jarmo
name: Skaaby, Tea
name: Chambers, John C.
name: Männistö, Satu
name: Jousilahti, Pekka
name: Malarstig, Anders
name: Lindgren, Cecilia M.
name: Bonnycastle, Lori L.
name: Munroe, Patricia B.
name: Melander, Olle
name: Asselbergs, Folkert W.
name: Robertson, Neil R.
name: Caulfield, Mark J.
name: Uusitupa, Matti
name: Spector, Timothy D.
name: Rolandsson, Olov
name: Tragante, Vinicius
name: Shaw-Hawkins, Susan
name: Van Der Harst, Pim
name: Marouli, Eirini
name: Freitag, Daniel F.
name: Vogt, Thomas F.
name: Porteous, David J.
name: Samani, Nilesh J.
name: Neville, Matt J.
name: Jukema, J Wouter
name: Polasek, Ozren
name: Bork-Jensen, Jette
name: Franks, Paul W.
name: Grarup, Niels
name: Brandslund, Ivan
name: Havulinna, Aki S.
name: Esko, Tõnu
name: Blankenberg, Stefan
name: Vergnaud, Anne-Claire
name: Huffman, Jennifer E.
name: Caslake, Muriel
name: Scotland, Generation
name: Rayner, N William
name: Jackson, Anne U.
name: Packard, Chris J.
name: Hveem, Kristian
name: Barnes, Daniel R.
name: Soranzo, Nicole
name: Lannfelt, Lars
name: Harakalova, Magdalena
name: De Craen, Anton J. M.
name: Tomaszewski, Maciej
name: Kuulasmaa, Kari
name: Elliott, Paul
name: Stanton, Alice V.
name: Willems, Sara M.
name: De Bakker, Paul I. W.
name: Justice, Anne E.
name: Husemoen, Lise L.
name: Luan, Jian'An
name: Drenos, Fotios
name: Müller-Nurasyid, Martina
name: Petersen, Eva R. B.
name: Zhao, Wei
name: Kraja, Aldi T.
name: Dominiczak, Anna F.
name: Ingelsson, Erik
name: Poulter, Neil
name: Hassinen, Maija
name: Groves, Christopher J.
name: Danesh, John
name: Numans, Mattijs E.
name: Yaghootkar, Hanieh
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants in up to ~192,000 individuals, and used ~155,063 samples for independent replication. We identified 31 novel blood pressure or hypertension associated genetic regions in the general population, including three rare missense variants in RBM47, COL21A1 and RRAS with larger effects (>1.5mmHg/allele) than common variants. Multiple rare, nonsense and missense variant associations were found in A2ML1 and a low-frequency nonsense variant in ENPEP was identified. Our data extend the spectrum of allelic variation underlying blood pressure traits and hypertension, provide new insights into the pathophysiology of hypertension and indicate new targets for clinical intervention.