cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1: of miR-29c plays a suppressive role in breast cancer by targeting the TIMP3/STAT1/FOXO1 pathway
Creators: name: Li, Wan
name: Yi, Jie
name: Zheng, Xiangjin
name: Liu, Shiwei
name: Fu, Weiqi
name: Ren, Liwen
name: Li, Li
name: Hoon, Dave
name: Wang, Jinhua
name: Du, Guanhua
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Plant Biology

description: Table S1. Sequence of DNMT3B siRNA. Table S2. Primers of miR-29c and DNMT3B. Table S3. Primers of TIMP3 for methylation specific PCR and unmethylation PCR. Figure S1. Quantification of protein expression level of DNMT3B in human breast cancer tissues and the paired adjacent non-tumor tissues. Figure S2. Migration and invasion of cells. Figure S3. miR-29c inhibited proliferation, migration and invasion, colony formation and growth in 3D Matrigel of MDA-MB-436 cells. Figure S4. DNMT3B promoted migration, invasion, colony formation and growth in 3D Matrigel of MDA-MB-231 miR-29c cells. Figure S5. Colony formation of cells. Figure S6. miR-29c reduced luciferase activity of wild type 3â UTR of DNMT3B-luciferase reporter, and not the mutant type 3â UTR of DNMT3B reporter in MCF-7 cells. Figure S7. Expression of DNMT3B, TIMP3, STAT1 and FOXO1. Figure S8. Migration and invasion of cells. (DOCX 3215 kb)
Additional file 10 of Whole-genome sequencing and genetic characteristics of representative porcine reproductive and respiratory syndrome virus (PRRSV) isolates in Korea
Creators: name: Kim, Seung-Chai
name: Moon, Sung-Hyun
name: Jeong, Chang-Gi
name: Park, Gyeong-Seo
name: Park, Ji-Young
name: Jeoung, Hye-Young
name: Shin, Go-Eun
name: Ko, Mi-Kyeong
name: Kim, Seoung-Hee
name: Lee, Kyoung-Ki
name: Cho, Ho-Seong
name: Kim, Won-Il
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 10. P value of seven methods (RDP, GENECONV, BootScan, Maxchi, Chimaera, SiScan, and 3Seq) applied in RDP4 software.
Clinicopathological and biochemical findings of thyroid amyloid in hereditary transthyretin amyloidosis with and without liver transplantation
Creators: name: Guannan Huang
name: Ueda, Mitsuharu
name: Tasaki, Masayoshi
name: Yamashita, Taro
name: Misumi, Yohei
name: Masuda, Teruaki
name: Suenaga, Genki
name: Yasuteru Inoue
name: Kinoshita, Yumiko
name: Matsumoto, Sayaka
name: Mizukami, Mayumi
name: Yukimoto Tsuda
name: Nomura, Toshiya
name: Konen Obayashi
name: Ando, Yukio
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer

description: Hereditary transthyretin (TTR) amyloidosis is a fatal disease causing systemic organ dysfunctions. Histopathological studies revealed that thyroid glands are major target tissues. However, details about thyroid functions remain to be fully elucidated in this disease. For patient treatment, liver transplantation (LT) reportedly prolongs patient survival, but thyroid gland function after LT still remains poorly understood. In this study, we investigated the thyroid functions in 101 patients with hereditary TTR amyloidosis and the effects of LT on thyroid functions in those patients. In addition, we investigated histopathological and biochemical findings of thyroid specimens obtained at autopsy. Disease duration and age at examination inversely correlated with serum levels of free triiodothyronine (fT3) in hereditary TTR amyloidosis. On the contrary, in patients who underwent transplantation, time from disease onset to transplantation and age at transplantation clearly correlated with serum fT3and thyroid stimulating hormone (TSH) levels. In autopsy studies, amounts of thyroid amyloid deposits in patients with transplantation were significantly lower than those in patients without transplantation. Mass spectrometric analyzes also revealed that proportions of wild-type (WT) TTR in thyroid amyloid deposits in patients with hereditary TTR amyloidosis who underwent transplantations were higher than those in patients without transplantation. Thyroid hormone functions may diminish according to the disease progression. LT could prevent thyroid dysfunction in hereditary TTR amyloidosis.
Additional file 2 of Whole-genome sequencing and genetic characteristics of representative porcine reproductive and respiratory syndrome virus (PRRSV) isolates in Korea
Creators: name: Kim, Seung-Chai
name: Moon, Sung-Hyun
name: Jeong, Chang-Gi
name: Park, Gyeong-Seo
name: Park, Ji-Young
name: Jeoung, Hye-Young
name: Shin, Go-Eun
name: Ko, Mi-Kyeong
name: Kim, Seoung-Hee
name: Lee, Kyoung-Ki
name: Cho, Ho-Seong
name: Kim, Won-Il
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2. Representative PRRSV strains used in this study.
Additional file 6 of Whole-genome sequencing and genetic characteristics of representative porcine reproductive and respiratory syndrome virus (PRRSV) isolates in Korea
Creators: name: Kim, Seung-Chai
name: Moon, Sung-Hyun
name: Jeong, Chang-Gi
name: Park, Gyeong-Seo
name: Park, Ji-Young
name: Jeoung, Hye-Young
name: Shin, Go-Eun
name: Ko, Mi-Kyeong
name: Kim, Seoung-Hee
name: Lee, Kyoung-Ki
name: Cho, Ho-Seong
name: Kim, Won-Il
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 6. BLAST results of newly assembled PRRSV whole-genome sequences.
Additional file 1: of Novel aggrecan variant, p. Gln2364Pro, causes severe familial nonsyndromic adult short stature and poor growth hormone response in Chinese children
Creators: name: Xu, Dandan
name: Sun, Chengjun
name: Zhou, Zeyi
name: Wu, Bingbing
name: Yang, Lin
name: Chang, Zhuo
name: Zhang, Miaoying
name: Xi, Li
name: Cheng, Ruoqian
name: Ni, Jinwen
name: Luo, Feihong
Publisher: name: figshare
Year: 2018
Subjects: Medicine
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Developmental Biology

description: Figure S1. The amino acid "Q" in red represents the conservative property in position "p. Gln2364Pro" among differet species. (PDF 416Â kb)
Additional file 8 of Whole-genome sequencing and genetic characteristics of representative porcine reproductive and respiratory syndrome virus (PRRSV) isolates in Korea
Creators: name: Kim, Seung-Chai
name: Moon, Sung-Hyun
name: Jeong, Chang-Gi
name: Park, Gyeong-Seo
name: Park, Ji-Young
name: Jeoung, Hye-Young
name: Shin, Go-Eun
name: Ko, Mi-Kyeong
name: Kim, Seoung-Hee
name: Lee, Kyoung-Ki
name: Cho, Ho-Seong
name: Kim, Won-Il
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 8. Multiple sequence alignment of PRRSV2 NSP2, with the “111 + 1 + 19” deletions indicated with black dashed-line boxes.
Additional file 2: of Novel aggrecan variant, p. Gln2364Pro, causes severe familial nonsyndromic adult short stature and poor growth hormone response in Chinese children
Creators: name: Xu, Dandan
name: Sun, Chengjun
name: Zhou, Zeyi
name: Wu, Bingbing
name: Yang, Lin
name: Chang, Zhuo
name: Zhang, Miaoying
name: Xi, Li
name: Cheng, Ruoqian
name: Ni, Jinwen
name: Luo, Feihong
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Figure S2. Black arrow: Cervical-vertebral cleft in the spine. White arrows: Apophyses in the upper and lower thoracic vertebrae. (PDF 2309Â kb)
Additional file 9 of Whole-genome sequencing and genetic characteristics of representative porcine reproductive and respiratory syndrome virus (PRRSV) isolates in Korea
Creators: name: Kim, Seung-Chai
name: Moon, Sung-Hyun
name: Jeong, Chang-Gi
name: Park, Gyeong-Seo
name: Park, Ji-Young
name: Jeoung, Hye-Young
name: Shin, Go-Eun
name: Ko, Mi-Kyeong
name: Kim, Seoung-Hee
name: Lee, Kyoung-Ki
name: Cho, Ho-Seong
name: Kim, Won-Il
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 9. SimPlot analysis querying potential major parent strains against Korean PRRSV isolates.
ФРАЗЕОЛОГИЧЕСКАЯ ЕДИНИЦА КАК ОБЪЕКТ ИЗУЧЕНИЕ ФРАЗЕОЛОГИИ
Creators: name: Убайдуллоева Наргиза учительница русского языка ПК №1 Ташкентского района
Publisher: name: Zenodo
Year: 2024

description: Фразеологические единицы занимают особое положение в структуре языка, находясь между словом (лексической единицей) и словосочетанием (синтаксической единицей). Изучение фразеологизмов является сложным объектом исследования. Фразеологические единицы являются двойственными: они образуют своеобразные устойчивые комбинации слов и одновременно имеют собственное лексическое значение, функционируя как номинативные единицы-лексемы.
Subpolygons in conway-coxeter frieze patterns
Creators: name: Cuntz, Michael
name: Holm, Thorsten
Publisher: name: Saint-Martin d’Hères : Centre Mersenne
Year: 2021
Subjects: subject: Cluster algebra
subject: Frieze pattern
subject: Polygon
subject: Quiddity cycle
subject: Tame frieze pattern
subject: Triangulation
subject: Dewey Decimal Classification::500 | Naturwissenschaften::510 | Mathematik

description: Friezes with coefficients are maps assigning numbers to the edges and diagonals of a regular polygon such that all Ptolemy relations for crossing diagonals are satisfied. Among these, the classic Conway-Coxeter friezes are the ones where all values are positive integers and all edges have value 1. Every subpolygon of a Conway-Coxeter frieze yields a frieze with coefficients over the positive integers. In this paper we give a complete arithmetic criterion for which friezes with coefficients appear as subpolygons of Conway-Coxeter friezes. This generalizes a result of our earlier paper with Peter Jørgensen from triangles to subpolygons of arbitrary size.
Additional file 1: of Factors associated with social participation amongst elders in rural Sri Lanka: a cross-sectional mixed methods analysis
Creators: name: Marsh, Celeste
name: Agius, Paul
name: Jayakody, Gamini
name: Shajehan, Roshan
name: Abeywickrema, Chandima
name: Durrant, Kelly
name: Luchters, Stanley
name: Holmes, Wendy
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Sociology
subject: FOS: Sociology
subject: Mathematical Sciences not elsewhere classified
subject: Computational Biology

description: English version of the Baseline Questionnaire used for the quantitative component of the study. (PDF 443 kb)
CONSUMER SENTIMENT ANALYSIS TO THE SERVICE PERFORMANCE OF THE INDONESIAN STATE ELECTRICITY COMPANY DURING THE COVID-19 PANDEMIC
Creators: name: NOVIE SUSANTI SUSENO
Publisher: name: Zenodo
Year: 2024
Subjects: Analytic Network Process, Marketing Mix, Naïve Bayes Classifier, Sentiment Analysis, Text Associations.

description: Abstract

This study aims to identify problems in the service performance of the State Electricity Company/PLN in Indonesia during the Covid-19 pandemic and to formulate priority solutions for service improvement. The methods used in this research are Naïve Bayes Classifier, Text Associations, and Analytic Network Process (ANP). The Naïve Bayes Classifier and Text Associations methods identify the most dominant problems based on social media's consumer perceptions. The recognized text associations refer to the marketing mix elements, including product, price, promotion, place, physical evidence, people, and process. The data sources in this study are consumer comments submitted on Twitter, Facebook, and PLN Mobile for the period March-June 2020. Furthermore, the ANP method is used to determine service improvement priorities, where the decision-makers in the weighting come from the company management. Based on Text Associations results, several dominant problems were identified: rising bills, slow response to consumer complaints, frequent power outages, unstable power supply voltages, and unreliable PLN-mobile applications. When referring to the marketing mix elements, these problems fall into product, price, and process. Furthermore, based on the ANP method's application, the main priority for improvement is to change the recording system for consumer kWh meters that are still using the conventional system (postpaid) to a token system (prepaid). This recommendation is considered appropriate to solve problems during the Covid-19 pandemic. There is no need to assign PLN employees to manually record bills through direct visits to consumer locations through its implementation. The next priority for improvement is the readjustment of distribution transformers and the upgrading of electricity grid technology. The combination of Naïve Bayes Classifier and Text Associations to Analytic Network Process (ANP) can broadly capture today's consumers' needs and wants to be used as a frame of reference in developing decision-making models to formulate priority solutions for service improvement.
Additional file 1: of N 6 -methyl-adenosine level in Nicotiana tabacum is associated with tobacco mosaic virus
Creators: name: Li, Zhurui
name: Shi, Jing
name: Yu, Lu
name: Zhao, Xiaozhen
name: Ran, Longlu
name: Hu, Deyu
name: Song, Baoan
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Hematology
subject: Plant Biology
subject: FOS: Biological sciences
subject: Virology

description: Figure S1. Calibration curves for the quantification of A in mRNA. The amounts of A ranged from 0.1–2.5 μmol. Figure S2. Calibration curves for the quantification of C in mRNA. The amounts of C ranged from 0.5–25 μmol. Figure S3. Calibration curves for the quantification of G in RNA. The amounts of G ranged from 0.25–12.5 μmol. Figure S4. Calibration curves for the quantification of U in RNA. The amounts of U ranged from 5 to 250 μmol. Figure S5. Calibration curves for the quantification of m6A in RNA. The amounts of m6A ranged from 0.005–0.250 μmol. Figure S6. Representative UHPLC-HR-MS/MS results for the quantification of A in N. tabacum K326 with selected-ion chromatograms. Figure S7. Representative UHPLC-HR-MS/MS results for the quantification of C in N. tabacum K326 with selected-ion chromatograms. Figure S8. Representative UHPLC-HR-MS/MS results for the quantification of U in N. tabacum K326 with selected-ion chromatograms. Table S1. Primer sequences for RT-qPCR analysis. (PDF 1250 kb)
The Desire to Escape from Death: A Biographical Reading of " Shadow — a Parable " by Edgar Allan Poe
Creators: name: Demir, Burak
Publisher: name: figshare
Year: 2017
Subjects: Literature

description: "Is it possible to consider an author separately from the environment he lives or his own life?" This question has been one of the most important questions debated by many critics for many years. With the progress and development of psychology, it is accepted fact that it is almost impossible to write a work completely abstracted from the life experiences and the social environment in which we interact. If the author that we are talking about is Edgar Allan Poe who is one the greatest poets who used the unfortunate circumstances of his life to write great works and experienced numerous difficulties and challenges in his forty year life, this question must examine thoroughly. This study reviews "Shadow — a Parable" in order to show how we can capture stunning clues about Poe’s life and the society he lived and also examine whether he was influenced the unfortunate circumstances of his life or not while he was writing this story.
ARRAY FACTOR OPTIMIZATION OF AN ACTIVE PLANAR PHASED ARRAY USING EVOLUTIONARY ALGORITHM
Creators: name: Bhattacharjee, Samaresh
name: Kumar, Ashish
name: Naja, Manish
Publisher: name: figshare
Year: 2018
Subjects: classificationCode: 400699
subject: Communications engineering not elsewhere classified

description: Evolutionary algorithms (EAs) have the potential to handle complex, multi-dimensional optimization problems in the field of phased array. Out of different EAs, particle swarm optimization (PSO) is a popular choice. In a phased array, antenna element failure is a common phenomenon and this leads to degradation of the array factor (AF) pattern, primarily in terms of increased side lobe levels (SLLs), displacement of nulls and reduction in the null depths. The recovery of a degraded pattern using a cost and time-effective approach is on demand. In this context, an attempt made to obtain an optimized AF pattern after fault in a 49 elements quasi-circular aperture equilateral triangular grid active planar phased array using PSO. In the paper, multiple cases on recovery are discussed having a maximum 20% element failure. Each recovery is also further evaluated by different statistical analyses. A dedicated software tool was developed to carry out the work presented in this paper
Economic evaluation of adverse events of dabrafenib plus trametinib versus nivolumab in patients with advanced BRAF-mutant cutaneous melanoma for adjuvant therapy in Germany
Creators: name: Wahler, S.
name: Müller, A.
name: Koll, C.
name: Seyed-Abbaszadeh, P.
name: Von Der Schulenburg, J.M.
Publisher: name: London : Taylor & Francis Group
Year: 2020
Subjects: subject: Combi-treatment
subject: cost burden
subject: dabrafenib
subject: nivolumab
subject: therapeutic strategy
subject: trametinib
subject: Dewey Decimal Classification::300 | Sozialwissenschaften, Soziologie, Anthropologie::330 | Wirtschaft

description: Background: Adjuvant treatment options have become the standard therapy for stage III and IV resectable cutaneous melanoma. Two recent studies led to the registration of dabrafenib and trametinib as targeted therapies for BRAF-mutated melanoma, and of immunotherapy with nivolumab irrespective of BRAF-mutation status. Both therapies have different spectrums of adverse events. Objective: To estimate the financial impact of side effects from the perspective of the German statutory sick funds to compare both therapeutic options and to relate the burden to the overall costs of the treatment. Study design and setting: Thirty-six adverse event categories for the combination of dabrafenib and trametinib (‘combi treatment’) and for nivolumab were extracted from the original publications of the studies named COMBI-AD and CheckMate 238. Patients and intervention: For all event categories a diagnosis and therapy recommendation were determined according to current national or international guidelines or from leading German textbooks. Main outcome measure: The resulting diagnostic steps, treatments, and therapies were evaluated with unit costs based on the German fee schedule for ambulatory physicians, the German G-DRG scheme, and the German drug price list. Results: The number of events with nivolumab per one hundred treatments amounted to 3.8 mandatory hospitalizations, 3.5 emergency care events and 0.8 life-threatening events. For the combi treatment, the respective number of events per one hundred treatments was 2.7, 1.8, and 0.5. The overall cost burden was calculated as €899 for nivolumab and €861 for combi-treatment. Conclusion: The treatment of adverse events resulting from adjuvant melanoma therapy showed comparable costs for both therapies.
The twisted forms of a semisimple group over an fq-curve
Creators: name: Bitan, Rony A.
name: Köhl, Ralf
name: Schoemann, Claudia
Publisher: name: Talence : Institut de Mathématiques de Bordeaux, Université Bordeaux
Year: 2021
Subjects: subject: Hasse principle
subject: Mots-clefs. Class number
subject: Tamagawa number
subject: étale cohomology
subject: Dewey Decimal Classification::500 | Naturwissenschaften::510 | Mathematik
subject: Dewey Decimal Classification::000 | Allgemeines, Wissenschaft::000 | Informatik, Wissen, Systeme::004 | Informatik

description: Let C be a smooth, projective and geometrically connected curve defined over a finite field Fq . Given a semisimple C −S-group scheme G where S is a finite set of closed points of C, we describe the set of (OS-classes of) twisted forms of G in terms of geometric invariants of its fundamental group F (G).
The Effects of Bilingualism on Bilingual People
Creators: name: Demir, Burak
Publisher: name: figshare
Year: 2017
Subjects: subject: Linguistics
subject: FOS: Languages and literature

description: The purpose of this study was to examine the effects of bilingualism on bilinguals, and their lives. Before starting study, the most important question in my mind was “how does bilingualism affect people?” I have made this study by reading many articles about bilingualism and talking a few bilinguals who live Trabzon. Bilingualism in children is positively related to classification, creativity, ability to thinking. They have more flexibility in thinking, greater sensitivity to language, and a better ear for listening. Research has shown positive effects of bilingualism on those linguistic abilities: early word segregation; sensitivity to language structure, control of language processing. Bilingual people can easily understand people from other countries and their cultures. Being bilingual has also been shown in the literature to have some advantages over being monolingual. Bilingual people also have advantages in education, due to cognitive development, and mental flexibility. The dominant belief at this time is that there is a superiority of different thinking abilities among bilinguals.
The Extended List of Turkish Loanwords in English Language
Creators: name: Demir, Burak
Publisher: name: figshare
Year: 2017
Subjects: subject: Linguistics
subject: FOS: Languages and literature

description: The purpose of this study was to examine the Turkish loanwords in English language whether they are common or archaic. Loanwords (can also be spelled loan words or loan-words) are words adobted by the speakers of one language from a different language. Borrowing is a consequence of cultural contact between two language communities. Loanwords can go in both directions between the two languages in contact, but often there is an asymmetry, that more words go from one side to the other. English language has gone through many periods in which large numbers of words from a particular language were borrowed. These periods coincide with times of major cultural contact between English speakers and those speaking other languages. The waves of borrowing during periods of especially strong cultural contacts are not sharply delimited, and can overlap. For example, the Norse influence on English began already in the 8th century and continued strongly well after the Norman Conquest. This study extendedly lists of Turkish loanwords which are used in English language.
Robust multi-objective optimization in product development with respect to user-scenario and manufacturing uncertainties
Creators: name: Wolniak, Philipp
name: Cramer, Jakob
name: Lachmayer, Roland
Publisher: name: Cambridge : Cambridge University Press
Year: 2021
Subjects: subject: Computational design methods
subject: Multi-objective optimization
subject: Robust design
subject: Uncertainty
subject: User-scenario
subject: Konferenzschrift
subject: Dewey Decimal Classification::600 | Technik::620 | Ingenieurwissenschaften und Maschinenbau

description: In product development, user-scenarios are a way of tailoring requirements to defined customer groups. Furthermore, a product design often involves multiple conflicting objectives that are analyzed within an iterative process. The models typically used for the analysis often do not accurately reflect the real-world representation. This can be alleviated by finding robust product designs. While usually uncertainties due to manufacturing tolerances are investigated, we additionally consider uncertainties in the user-scenario. Therefore, we present a robustness evaluation in a multi-objective numerical optimization in product development. For this, we consider manufacturing tolerances using an adjusted Latin Hypercube Sampling as well as deviations in the user-scenario by means of a Gaussian distribution. In the case study, we present the robust development of a customer specific coffee machine, where we show the robustness evaluation and the impact of the proposed adjustments. The advantage of the presented process is a product design tailored to the customer's requirements under specified uncertainties. In addition, this enables a time benefit in the product development due to the automated analysis used in the optimization.
Three Ways in Which Pandemic Models May Perform a Pandemic
Creators: name: Van Basshuysen, Philippe
name: White, Lucie
name: Khosrowi, Donal
name: Frisch, Mathias
Publisher: name: Rotterdam : Erasmus Univ.
Year: 2021
Subjects: subject: Covid-19
subject: epidemiological models
subject: model evaluation
subject: performativity
subject: prediction
subject: success
subject: Dewey Decimal Classification::100 | Philosophie
subject: Dewey Decimal Classification::300 | Sozialwissenschaften, Soziologie, Anthropologie::330 | Wirtschaft

description: Models not only represent but may also influence their targets in important ways. While models' abilities to influence outcomes has been studied in the context of economic models, often under the label ‘per-formativity', we argue that this phenomenon also pertains to epidemiological models, such as those used for forecasting the trajectory of the Covid-19 pandemic. After identifying three ways in which a model by the Covid-19 Response Team at Imperial College London (Ferguson et al. 2020) may have influenced scientific advice, policy, and individual responses, we consider the implications of epidemiological models' performative capacities. We argue, first, that performativity may impair models' ability to successfully predict the course of an epidemic; but second, that it may provide an additional sense in which these models can be successful, namely by changing the course of an epidemic.
Hypotheses
Creators: name: Salomon, Tom
Publisher: name: OSF Registries
Year: 2018

description: Hypotheses: Main experimental hypotheses: 1. Associative learning effect for trained IAPS stimuli: In probe choices, participants will choose the Go item over the No-Go training items in greater rates in comparison with baseline. 2. Generalization of learning effect for untrained IAPS stimuli: In probe choices, participants will choose the Go item over the No-Go generalization stimuli in greater rates in comparison with baseline. 3. Generalization of learning effect for untrained face stimuli: In probe choices, participants will choose the Go item over the No-Go face stimuli in greater rates in comparison with baseline. Secondary hypotheses: 4. Decline of the effect with generalization: We expect the preferences modification effects to be strongest for the IAPS stimuli that were in the training procedure (training stimuli set), lesser for the IAPS stimuli of the same arousal level that were not in the training task (generalization stimuli), and weakest (yet still significant) for the face stimuli.
Small-sized magnesium cylinders influence subchondral bone quality in osteoarthritic rabbits an – in vivo pilot study
Creators: name: Angrisani, N.
name: Willumeit-Römer, R.
name: Windhagen, H.
name: Mavila Chathoth, B.
name: Scheper, V.
name: Wiese, B.
name: Helmholz, H.
name: Reifenrath, J.
Publisher: name: Aberystwyth, Wales : Univ. of Wales
Year: 2021
Subjects: subject: bone density
subject: bone structure
subject: cartilage
subject: degradation
subject: In vivo
subject: magnesium
subject: osteoarthritis progression
subject: Dewey Decimal Classification::600 | Technik::610 | Medizin, Gesundheit
subject: Dewey Decimal Classification::500 | Naturwissenschaften::540 | Chemie

description: No optimal therapy exists to stop or cure chondral degeneration in osteoarthritis (OA). While the pathogenesis is unclear, there is consensus on the etiological involvement of both articular cartilage and subchondral bone. Compared to original bone, the substance of sclerotic bone is mechanically less solid. The osteoproliferative effect of Mg has been shown repeatedly during development of Mg-based osteosynthesis implants. The aim of the present study was to examine the influence of implanted high-purity Mg cylinders on subchondral bone quality in a rabbit OA model. 10 New Zealand White rabbits received into the knee either 20 empty drill holes or 20 drill holes, which were additionally filled with one Mg cylinder each. Follow-up was at 8 weeks. Micro-computed tomography (µCT) was performed. After euthanasia, cartilage condition was determined, bone samples were collected and processed for histological evaluation and elemental imaging by micro-Xray fluorescence spectrometry (µXRF). Articular cartilage collected post-mortem showed different stages of lesions, from mild alterations up to exposed subchondral bone, which tended to be slightly lower in animals with implanted Mg cylinders. µCT showed significantly increased bone volume in the Mg group. Also, histological evaluation revealed distinct differences. While right, operated limbs did not show any significant difference, left, non-operated controls showed significantly less changes in articular cartilage in the Mg group. A distinct influence of implanted cylinders of pure Mg on subchondral bone of osteoarthritic rabbits was shown. Subsequent evaluations, including other time points and alternative alloys, will show if this could alter OA progression.
Additional file 1 of Recursive partitioning analysis for survival stratification and early imaging prediction of molecular biomarker in glioma patients
Creators: name: Xie, Xian
name: Luo, Chen
name: Wu, Shuai
name: Qiao, Wanyu
name: Deng, Wei
name: Jin, Lei
name: Lu, Junfeng
name: Bu, Linghao
name: Duffau, Hugues
name: Zhang, Jie
name: Yao, Ye
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Cell Biology
Pharmacology
Biotechnology
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Mathematical Sciences not elsewhere classified
Cancer

description: Supplementary Material 1
title: Comparative study of antiviral IFITM proteins in reservoir bat species
Creators: name: Mak, Shui Ching Nelly
Publisher: name: The University of Edinburgh
Year: 2025
Subjects: subject: IFITM proteins
subject: Bats
subject: Antiviral immunity
subject: Alternative splicing
subject: Zoonosis

description: Species-specific innate immune responses are shaped by the virus-host arms race and contribute to the species barrier against zoonosis. Interferon-induced transmembrane proteins (IFITMs) are key players in the antiviral interferon response and act by inhibiting viral entry. The unique IFITM repertoires of different species may influence their resistance to viral infections. Bats are reservoir hosts for many zoonotic viruses and their enhanced antiviral immunity has been proposed to be important for this, but whether IFITMs play a role is unclear. In this thesis, the comparative analysis of mammalian IFITM families reveals frequent IFITM gene duplication events, highlighting the importance of IFITM diversity as a component of innate immunity. An important functional motif, the amphipathic helix, has reduced amphipathicity in bat IFITMs which is predicted to alter their antiviral activity. Characterisation of IFITMs in Chinese rufous horseshoe bat, a natural host of SARS-related coronaviruses, shows that alternatively spliced IFITM isoforms can exhibit distinct antiviral specificities against influenza A virus, Nipah virus and coronaviruses including MERS-CoV, SARS-CoV and SARS-CoV-2. Besides their antiviral function, IFITMs can modulate interferon production, suggesting that they have effects beyond restricting viral entry that may also influence viral immunopathogenesis. Further bioinformatic analysis in 206 mammals reveals that IFITM alternative splicing is an underappreciated evolutionary strategy to generate diversity and is more prevalent in bats relative to other mammals. Increased frequency of alternative splicing is also evident in immune-related genes in humans which is consistent with the selection pressures imposed by the virus-host arms race. These findings identify alternative splicing as a key source of functional innovation in immunity and a strategy that may be used by reservoir bat species to fine-tune their antiviral immune response by regulating the expression of functionally distinct IFITM isoforms. My comparative analysis showcases the power of this approach to uncover novel features of gene functions. Similar studies to understand the unique antiviral immune responses in bats can guide the development of therapeutic strategies to treat viral infections and immunopathologies.
title: Seasonal Phytoplankton Assemblages of Five Ephemeral Ponds in York County, Virginia
Creators: name: Kokolis, Michelle R.
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 2001

description: Five ephemeral ponds were identified in and around the Grafton Ponds Natural Area Preserve, approximately 56 km north of the City of Norfolk, Virginia. These ponds, which are filled seasonally by precipitation and groundwater discharge, range from 0.1 ha to 2 ha in size and from 4 cm to 3 meters in depth. Ponds for the study were chosen based on variations in their size, depth, basin cover material, canopy openness, and historical inundation period. The purpose of this study is to relate differences in the phytoplankton assemblages to the physical and chemical characteristics of the ponds. All five ponds followed the expected seasonal patterns for water temperature and depth, and maintained a stable acidity throughout 1999. There were 119 taxa identified, 36 of which were in all five ponds. Shannon Diversities ranged from 0.94 — 2.66. Bray-Curtis Dissimilarity values ranged from 3.8 — 54.3. The larger ponds were typically more similar to each other and the smaller ponds were typically more similar to each other. Three ponds exhibited seasonal patterns that were dominated by chlorophytes in the cooler months and cyanobacteria in the warmer months. Dinoflagellates dominated the fourth pond during the cooler months. The fifth pond maintained a diverse community year round. Cryptomonas erosa was predominant in all five ponds during the late summer.
title: Anti-attachment peptides
title: a novel therapeutic strategy to control group A streptococcal infection in the Northern Territory of Australia
titleType: Subtitle
Creators: name: Kennedy, Mandy
Publisher: name: Charles Darwin University
Year: 2004

description: The pathogen Streptococcus pyogenes (group A streptococcus, GAS) is the causative agent of numerous human diseases. It can be carried asymptornatically, or may cause a variety of clinical syndromes including pharyngitis and pyoderma, and severe invasive diseases such as necrotising fasciitis and toxic shock syndrome. Whereas less severe infections are generally self-limiting, the sequelae of GAS infection are potentially life threatening. The two major non-suppurative sequelae are acute poststreptococcal glomeruloncphritis (APSGN) and acute rheumatic fever (ARF). The binding of bacterial cell surface adhesins to host receptor molecules is one of the most critical steps in microbial colonisation and pathogenesis. In GAS, attachment requires many adhesins including M protein, lipoteichoic acid and fibronectin binding proteins (FBPs). Of these, FBPs are known to be major contributors to adhesion. The aim of this study is to develop an anti-adhesion strategy to inhibit the attachment of GAS to host cells, thereby preventing colonisation and subsequent infection. In our study we aim to use synthetic peptides corresponding to one of the streptococcal FBPs to block the attachment of GAS to host cells. This approach is not expected to interfere with the body's normal flora as the peptide would bind specifically to the GAS receptor on the host cell. It is hypothesised that prevention of GAS attachment to skin or throat cells in turn will prevent the establishment of infection. Fifty six percent of NT GAS isolates tested in this study contained the gene for SfbI, a major GAS FBP. A peptide (peptide MSG) based on this adhesin inhibits fibronectin-binding by the pathogen. To test whether this peptide also blocks attachment of GAS to host cells adhesion assay were performed with strains possessing different combinations of genes for three distinct FBPs, including SfbI. This peptide successfully inhibited attachment of 40% of GAS isolates tested.Success of this inhibition was not associated with the number of FBP genes encoded by the isolate or by its fibronectin binding capacity, but appears to be dependent upon the individual GAS isolate and the target host cell. In summary,this approach has proven successful and further investigation will tell us whether the peptide tested is likely to be an effective prophylactic measure for GAS infection in this population.
Knowledge Graph Generator (KGG): An automated workflow to create disease-specific Knowledge Graphs
Creators: name: Karki, Reagon
Publisher: name: Zenodo
Year: 2024

description: The Knowledge Graph Generator (KGG) workflow allows users to create KGs representing chemotype-phenotype of diseases of interest. The KGG is developed such that it is able to generate KGs with a minimum input (i.e., standard disease id) which users are prompted to identify at the beginning of the workflow. Additionally, the users can customize the size and content of KG with options to choose number of proteins and clinical trial phase of chemicals to be represented in the KG. The final KG is composed of disease-associated entities such as proteins, protein-related pathways, biological processes and functions, chemicals, mechanism of actions, assays and adverse effects. This is achieved by embedding underlying schema of curated databases (such as OpenTargets, Uniprot, ChEMBL and so on) which resemble a clockwork-esque mechanism.
Virtual element formulation for finite strain elastodynamics
Creators: name: Cihan, Mertcan
name: Hudobivnik, BlaŽ
name: Aldakheel, Fadi
name: Wriggers, Peter
Publisher: name: Henderson, Nevada : Tech Science Press
Year: 2021
Subjects: subject: Dynamics
subject: Finite strains
subject: Three-dimensional
subject: Virtual element method
subject: Dewey Decimal Classification::000 | Allgemeines, Wissenschaft::050 | Zeitschriften, fortlaufende Sammelwerke
subject: Dewey Decimal Classification::600 | Technik::690 | Hausbau, Bauhandwerk

description: The virtual element method (VEM) can be seen as an extension of the classical finite element method (FEM) based on Galerkin projection. It allows meshes with highly irregular shaped elements, including concave shapes. So far the virtual element method has been applied to various engineering problems such as elasto-plasticity, multiphysics, damage and fracture mechanics. This work focuses on the extension of the virtual element method to efficient modeling of nonlinear elasto-dynamics undergoing large deformations. Within this framework, we employ low-order ansatz functions in two and three dimensions for elements that can have arbitrary polygonal shape. The formulations considered in this contribution are based on minimization of potential function for both the static and the dynamic behavior. Generally the construction of a virtual element is based on a projection part and a stabilization part. While the stiffness matrix needs a suitable stabilization, the mass matrix can be calculated using only the projection part. For the implicit time integration scheme, Newmark-Method is used. To show the performance of the method, various two- and three-dimensional numerical examples in are presented.
The Power of Nature and the Supernatural Powers in William Shakespeare's "Macbeth"
Creators: name: Demir, Burak
Publisher: name: figshare
Year: 2017
Subjects: Literature

description: This study examines the power of nature and the supernatural powers in Macbeth, the last and the shortest of Shakespeare’s great tragedies, and their influence on the course of events in the play. Macbeth is the one of Shakespeare plays that supernatural figures and elements take place at most. The mainstays of the play are developing events as a result of the prophecies of the witches, supernatural powers’ triggering human greed and as a result of this, deterioration, distortion and disorder occurring on the universal order. In this study, in which cases the harmony and balance of nature is impaired, what happens as a result of this deterioration and the perspectives of the people of Shakespeare’s era about the witches were examined with comments by famous critics.
Planning of Reserve Storage to Compensate for Forecast Errors
Creators: name: Koch, Julian
name: Bensmann, Astrid
name: Eckert, Christoph
name: Rath, Michael
name: Hanke-Rauschenbach, Richard
Publisher: name: Basel : MDPI
Year: 2024
Subjects: subject: day-ahead and intraday energy market
subject: energy management
subject: energy storage system
subject: multienergy system
subject: uncertain load forecast
subject: Dewey Decimal Classification::600 | Technik::620 | Ingenieurwissenschaften und Maschinenbau

description: Forecasts and their corresponding optimized operation plans for energy plants never match perfectly, especially if they have a horizon of several days. In this paper, we suggest a concept to cope with uncertain load forecasts by reserving a share of the energy storage system for short-term balancing. Depending on the amount of uncertainty in the load forecasts, we schedule the energy system with a specific reduced storage capacity at the day-ahead market. For the day of delivery, we examine the optimal thresholds when the remaining capacity should be used to balance differences between forecast and reality at the intraday market. With the help of a case study for a simple sector-coupled energy system with a demand for cooling, it is shown that the energy costs could be reduced by up to 10% using the optimal reserve share. The optimal reserve share depends on the forecast quality and the time series of loads and prices. Generally, the trends and qualitative results can be transferred to other systems. However, of course, an individual evaluation before the realization is recommended.
Bagging prevents russeting and decreases postharvest water loss of mango fruit cv. ‘Apple’
Creators: name: Athoo, Thomas O.
name: Yegon, Dennis
name: Owino, Willis O.
name: Knoche, Moritz
Publisher: name: Amsterdam [u.a.] : Elsevier Science
Year: 2024
Subjects: subject: Bag
subject: Cuticle
subject: Lenticel
subject: Periderm
subject: Permeance
subject: Quality
subject: Russet
subject: Transpiration
subject: Dewey Decimal Classification::500 | Naturwissenschaften::570 | Biowissenschaften, Biologie
subject: Dewey Decimal Classification::600 | Technik::630 | Landwirtschaft, Veterinärmedizin

description: In Kenya, the mango (Mangifera indica L) cultivar ‘Apple’ is commercially important but it often suffers excessive russeting, which both compromises its appearance and impairs its postharvest performance. Together, these effects seriously reduce its market potential. Exposure to surface moisture is implicated in russeting of cv. ‘Apple’ mango. The objective was to establish the effect of bagging on russeting. Developing fruit were bagged at the onset of the exponential growth phase, using brown paper bags (Blue star®). Un-bagged fruit served as controls. The brown paper bags were selected because of their high permeance to water vapor. At harvest maturity, bagged fruit were larger, less russeted and had smaller lenticels than un-bagged control fruit. Staining with aqueous acridine orange in conjunction with fluorescence microscopy revealed numerous microcracks and larger lenticels on un-bagged control fruit but these were not evident on bagged fruit. Postharvest mass loss (principally water loss) of bagged fruit was lower than of un-bagged control fruit. In the un-bagged control fruit, the skin's water permeance increased as the russeted surface area increased (r2 = 0.88 **). Fruit skins were less permeable to water vapor than the brown paper bags. The brown paper bags contributed not more than 4.2 to 9.1% of the total in-series diffusion resistance of skin + bag. The masses of isolated cuticular membranes, and of dewaxed cuticular membranes, and of wax per unit surface area were higher for un-bagged control fruit than for bagged fruit. Bagged fruit were also greener and showed less blush. There was little difference in skin carotenoid content between bagged and un-bagged control fruit, but skin anthocyanin content was lower in bagged fruit. The rates of respiration and ethylene evolution of bagged fruit were lower than those of un-bagged control fruit. There were no differences between bagged and un-bagged control fruit in their organoleptic and nutritional properties including titratable acidity, total soluble sugars, sucrose, glucose, fructose, vitamin C and calcium content. In conclusion, bagging decreased russeting and increased postharvest performance of fruit of mango cv. ‘Apple’.
Improved understanding of combined sewer systems using the Illinois Conveyance Analysis Program (ICAP)
Creators: name: Oberg, Nils
name: Schmidt, Arthur R.
name: Landry, Blake J.
name: Leon, Arturo S.
name: Waratuke, Andrew R.
name: Mier, José M.
name: García, Marcelo H.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy

description: Understanding the conveyance of sewer networks is vital, especially in cases of great variability in flow rates, such as in combined sanitary and storm sewer systems. Conventional conveyance studies in sewer systems often have extended computation times due to complexity of the solution, or alternatively make assumptions that ignore the water-surface profile within a pipe. In previous research, the hydraulic performance graph (HPG) was successfully used for open-channel capacity determination. The HPG summarizes the results of many backwater calculations for a reach so that these calculations do not need to be repeated. This article describes algorithms utilized by the Illinois Conveyance Analysis Program that uses the HPGs to describe the conveyance of a system, identify bottlenecks for varying conditions, conserve mass by tracking outflow and overflows under stepwise steady flow conditions. The software is freely available at https://github.com/obergshavefun/icap/wiki.