cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Investigation of the use of histone deacetylase inhibitors for the treatment of inherited disorders of the glycolytic pathway
Creators: name: Makarona, Kalliopi
Publisher: name: Imperial College London
Year: 2013

description: Histone acetylation by histone acetyltransferases (HATs) and deacetylation by histone deacetylases (HDACs) regulate gene expression by activating or repressing transcription, respectively. HDAC inhibitors (HDACIs) are a diverse class of drugs used to treat haemoglobinopathies, urea cycle disorders and several types of malignancies. Recent evidence from genome-wide as well as gene-specific epigenetic studies suggest a model whereby active genes are more likely than silent genes to be hyperacetylated and increase their transcription levels in response to HDACIs, a process underpinned by the dynamic recruitment and antagonistic activities of HATs and HDACs. Based on this model and from a therapeutic perspective, I hypothesised that the ability of HDACIs to increase expression of active genes might be relevant for diseases caused by genes that encode proteins with enzymatic function. HDACI-mediated increase in gene transcription, even in the presence of missense, disease-causing mutations, might lead to increased enzymatic activity and amelioration of the cellular and clinical phenotype. I tested this hypothesis on a group of genes involved in the glycolytic and pentose phosphate pathway (GPPP) which, when mutated, cause chronic or episodic haemolytic anaemia. Using RT-qPCR (B cell lines) and gene expression profiling (primary, in vitro generated human erythroid precursors and CD4+ T cells) I found that of the 17 GPPP genes, only Glucose-6-Phosphate Dehydrogenase (G6PD) mRNA levels increased in response to HDACIs in a time-dependent manner. Epigenetic analysis in B cells by ChIP-qPCR showed that histone hyper-acetylation and increased recruitment of HATs and HDACs underpin the selective G6PD transcriptional activation in response to HDACIs. Pharmacological and genetic assays showed that increase in G6PD transcription was also dependent on Sp1, a generic transcription factor known to recruit both HDACs and HATs. Finally, I directly tested the hypothesis that HDACIs may increase enzymatic activity in G6PD deficient cells. Using B cell lines and primary erythroid cells from patients with G6PD deficiency, I found that HDACIs induce the same epigenetic changes in the mutant as in the wild type G6PD gene; more importantly, they lead to increased levels of the mutant mRNA and protein, associated with an up to 3-fold increase in enzymatic activity. These findings are potentially of great therapeutic significance for correction of G6PD deficiency in up to 300 million individuals worldwide with the polymorphic variants of G6PD deficiency (e.g., G6PDMed and G6PDA-).
Nonradiative emission and absorption rates of quantum emitters embedded in metallic systems: microscopic description and their determination from electronic transport
Creators: name: Neto, M. B. Silva
name: D'Angelis, F. M.
name: Foster, P. P. P.
name: Pinheiro, F. A.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: We investigate nonradiative emission and absorption rates of two-level quantum emitters embedded in a metal at low temperatures. We obtain the expressions for both nonradiative transition rates and identify a unique, experimentally accessible way to obtain the nonradiative decay rates via electronic transport in the host metallic system. Our findings not only provide a microscopic description of nonradiative decay channels in metals, but they also allows one to identify and differentiate them from other decay channels, which is crucial to understand and control light-matter interactions at the nanoscale.
description: 7 pages, 4 figures
Highly instrumented static, dynamic, and impact testing of high performance materials
Creators: name: Cwik, Tomasz
Publisher: name: Imperial College London
Year: 2013

description: This thesis presents an investigation into potential improvements in the ballistic performance of high performance composite materials by hybridizing them with other polymer materials. The main focus is on extraction of quantitative information from ballistic trials with armour grade composite materials. The primary goal of the research in this thesis is to understand the behaviour of high performance composites and polymer materials during ballistic impact events. To design a novel hybrid composite material system, an in-depth knowledge of the hybrid material constituents must be gained. The research performed to meet this objective is presented in this thesis and is divided into four main parts, preceded by a literature review of these topics (Chapter 2). It is believed that the ballistic performance of armour grade composite materials is dependent to a certain extent on the tensile properties of the reinforcement phase (i.e. fibres). Therefore, the first part of the thesis (Chapter 3) presents an evaluation of the static tensile yarn performance of 16 different high tenacity fibres. The goal of part two of the research was to evaluate dynamic properties of the same fibres in dynamic conditions by means of a tensile split Hopkinson bar. Chapter 4 presents conclusions from the experiments employing standard Hopkinson pressure bar for fibre testing. The third part of the thesis (Chapter 5) focuses on the evaluation of the ballistic performance of various materials which could be utilized in a hybrid armour system. A highly instrumented ballistic setup was established to measure armour deformation characteristics during the impact event. The measured ballistic data allowed the derivation of the ballistic limit of each material system and for a relative comparison of the ballistic performance between the different material systems and their applicability as an armour. The damage within the ballistic panels were further investigated using Computed Tomography and Computed Laminography scans. The final part of this thesis (Chapter 6) presents studies dedicated to the design of novel material systems of improved ballistic performance. A wide range of hybrids were investigated and conclusions drawn on the optimum route to improve the ballistic limit of a polymer amour system.
A critical re-evaluation of the Thorne-Żytkow object candidate HV 2112
Creators: name: Beasor, Emma R.
name: Davies, Ben
name: Cabrera-Ziri, Ivan
name: Hurst, Georgia
Publisher: name: arXiv
Year: 2018
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: It has been argued in the literature that the star HV~2112 in the Small Magellanic Cloud is the first known example of a TŻO, a Red Supergiant with a degenerate neutron core. This claim is based on the star having a high luminosity ($\log (L/L_\odot)$~> 5), an extremely cool effective temperature, and a surface enriched in in lithium, calcium and various $irp$-process elements. In this paper we re-examine this evidence, and present new measurements of the stellar properties. By compiling archival photometry from blue to mid-IR for HV~2112 and integrating under it's spectral energy distribution we find a bolometric luminosity in the range of $\log (L/L_\odot)$=4.70-4.91, lower than that found in previous work and comparable to bright asymptotic giant branch (AGB) stars. We compare a VLT+XSHOOTER spectrum of HV~2112 to other late type, luminous SMC stars, finding no evidence for enhancements in Rb, Ca or K, though there does seem to be an enrichment in Li. We therefore conclude that a much more likely explanation for HV~2112 is that it is an intermediate mass($\sim$5M$_\odot$) AGB star. However, from our sample of comparison stars we identify a new TŻO candidate, HV~11417, which seems to be enriched in Rb but for which we cannot determine a Li abundance.
description: Accepted for publication in MNRAS, 5 pages, 4 figures
Strings as a Model for Parent and Baby Universes: Total Splitting Rates
Creators: name: Nirov, Khazret S.
name: Rubakov, Valery A.
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Emission of hard microscopic string (graviton) by an excited macroscopic string may be viewed as a model of branching of a $(1+1)$-dimensional baby universe off large parent one. We show that, apart from a trivial factor, the total emission rate is not suppressed by the size of the macroscopic string. This implies unsuppressed loss of quantum coherence in $(1+1)$-dimensional parent universe.
description: 12 pages, LaTeX, 2 figures (bezier.sty)
In situ synchrotron tomography of granular deformation in semi-solid Al-Cu alloys
Creators: name: Kareh, Kristina Maria
Publisher: name: Imperial College London
Year: 2013

description: Optimising casting routes involving semi-solid deformation such as semi-solid processing and high-pressure die casting requires a fundamental understanding of the globule-scale mechanisms behind the macroscopic rheological behaviour. This thesis uses time-resolved 3D imaging to directly observe and measure semi-solid alloy deformation from a microstructural perspective. Under isothermal conditions and constant strain rates, deformation mechanisms both at the crystal scale and at the specimen scale were identified during deformation in globular Al-Cu alloys at 64-93% solid. Imaging and quantifying these mechanisms has led to the emergence of a refined understanding of semi-solid deformation based on granular material concepts. It is shown that globularised crystals (above fs> 60%) exclusively rearrange as individual grains during parallel plate compression and backward extrusion at low strain rates. Crystal-crystal interactions are identified for the two loading modes and are not accompanied by plastic deformation of the individual crystals during acquisition. The ubiquitous grain rearrangement is coupled with shear-induced dilation of the solid assembly, whereby the crystals push each other apart in order to accommodate the increasing strain. It is also shown that, for specimens lacking a liquid reservoir, shear-induced dilation causes menisci to be pulled into the specimen from the surface and additionally, at high solid fractions, internal pores to grow. The origins of cracking during semi-solid processing are explored in a granular framework and linked to the shear-induced dilation associated with the solid assembly which increases the initial width of the liquid channels between the grains. Finally, the discrete grain analysis is coupled with the bulk mechanical results to explore the shape of the stress-strain curve and relate it to the imaged and quantified behaviours. All solid fractions tend to the same final stress, hinting at the possibility of a critical state analogous to that in soil mechanics, although fully testing this hypothesis requires varying the confining pressure.
High Redshift X-ray Clusters and ${Ω_{0}}$
Creators: name: Sadat, R.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: X-ray clusters are powerful tools for the determination of cosmological parameters. More specifically, the combined knowledge of the redshift distribution of X-ray clusters together with the luminosity-temperature correlation, $L_X-T_X$ provides us a new test for constraining the mean density of the universe ${Ω_{0}}$. After a brief description of this test, I will present the result of our first attempt to apply this test to current X-ray data.
description: 4 pages, Latex, 2 figures, to appear in the Proceedings on : The non-sleeping Universe, ed. T. Lago, A. Blanchard, Astronomy and Space Science (special issue) held in Porto, Nov. 1997
Oral history interview with Lucile H. Bluford, 1971
Publisher: name: Columbia University
Year: 2019
Subjects: Journalists
Editors
African American press
African American journalists
African American women journalists
Newspaper publishing--Economic aspects--United States
African Americans--Civil rights
Advertising--Newspapers

description: In this interview, Bluford discusses: her tenure at the Kansas City Call; the legal and cultural gains of the black press; her family’s move to Kansas City from Salisbury, North Carolina; her work on her high school paper; and her summer job at the Call. Bluford mentions her year at the Atlanta Daily World, after which she became a general reporter and then city editor at the Call under Frank A. Young. She discusses the philosophy of Chester A. Franklin, Kansas City Call founder, and his battle with Parkinson’s Disease. Bluford describes: the Call’s limited resources, citing challenges in advertising, staff, and customer feedback; her work with young black journalists; the role of the black press as a historic protest tool for social change, as well as a record-keeping tool in black communities; and the pros and cons of increasing coverage of black communities by the white media. She concludes with a conversation on Louis R. Lautier, the United Press International, and the evolving hiring practices at both the Call and the Kansas City Star.
Plasmonics at liquid-liquid interfaces
Creators: name: Turek, Vladimir
Publisher: name: Imperial College London
Year: 2014

description: The PhD has studied gold nanoparticles (NPs) at the liquid-liquid interface (LLI). Some of the key aspects of the work are listed below. • Centrifugation as a novel and efficient method for adsorbing a controlled number of NPs to the LLI. • Controlled and tuneable 2D interparticle separation at the LLI as evidenced by the plasmon ruler. • Reversible adsorption of 16 nm gold nanoparticles at the water-DCE interface. • Centrifugation as a novel method to form an ultra-concentrated NP aqueous phase. • Controlled and tuneable 3D inter-particle separation in water by ultra-concentration. • The ultra-concentrated NP solution has some ‘record-breaking’ physical properties – e.g. densities in excess of 4.5 gcm-3; optical densities in excess of 70,000; and active surface areas of in excess of 70 m2/mL. • Ultra-concentration is also demonstrated as an efficient purification and NP size-separation technique with efficiencies in excess of 99.9% and 99.5%, respectively. • Close-packed NPs at the LLI are also demonstrated to be an efficient sensing platform through surface enhanced Raman spectroscopy. • The platform benefits from: fmole detection limits; extremely facile, quick and cheap assembly; applicability to a wide range of target analytes; both hydrophilic and hydrophobic detection capabilities simultaneously. • Through evaporation of the organic phase, the platform is also demonstrated to be able to identify and estimate concentrations of airborne analytes. • Finally, 1,8-diaminonaphthalene and its analogues are demonstrated to be extremely efficient mercury reporters when combined with SERS at the LLI. • A dramatic increase in SERS intensity is observed in the presence of mercury – though the exact reason for such an increase is still under investigation, some potential mechanisms are provided. • As with other analytes, NPs at the liquid-air interface demonstrate airborne mercury detection capabilities and this is demonstrated for the first time using SERS.
title: ADCO, Grènetier de Cîteaux : comptes (1497-1504) (11 H 1172), f. 00276
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: comptes
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172), f. 00276, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
The Integrative Physiology of the Plasma Membrane Calcium ATPase in Platelets
Creators: name: Solomon, Antonia Bibiana
Publisher: name: Imperial College London
Year: 2011

description: Plasma Membrane Calcium-ATPases (PMCA’s) extrude calcium from a variety of cell types and have recently been shown to regulate signalling events and function in the cardiovascular system. PMCA (isoform 4) is expressed in platelets, however its functional role remains undefined. The aims of this project were to investigate the roles of PMCA in regulating calcium homeostasis and human platelet function during the various stages of platelet activation by evaluating the effects of a pharmacological inhibitor of PMCA, carboxyeosin, upon a range of in vitro and in vivo assays. Additional experiments were performed to determine the functional consequences of PMCA4 ablation using platelets from PMCA4 knock-out mice and the roles of PMCA were contrasted with other calcium transporters. Finally, the mechanism of action of PMCA in platelets was investigated by integrating molecular studies with the functional assays. The findings presented in this thesis suggest that PMCA plays an important role in regulating calcium both basally and during platelet activation. PMCA positively regulates platelet aggregation through the modulation of negative signalling pathways but negatively regulates the earlier and later stages of activation measured as adhesion and clot retraction respectively. PMCA also regulates platelet function in vivo. Experiments in PMCA4 knock-out mice implicated the PMCA4 isoform in the regulation of platelet function. Comparison of PMCA, SERCA (sarcoendoplasmic reticulum ATPase) and NCX (Na+/Ca2+-exchanger) pumps indicated that all three calcium transporters play pivotal but contrasting roles in platelet function and calcium homeostasis. In conclusion, PMCA is a key regulator of calcium homeostasis and differentially regulates the various stages of platelet activation. PMCA regulates intracellular signalling events in platelets although the mechanisms remain to be fully determined. PMCA is therefore a key modulator of haemostasis and thrombosis and may be a potential target in the treatment of conditions such as arterial thrombosis and stroke.
Fractional jumps: complete characterisation and an explicit infinite family
Creators: name: Guidi, Federico Amadio
name: Micheli, Giacomo
Publisher: name: arXiv
Year: 2018
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: In this paper we provide a complete characterisation of transitive fractional jumps by showing that they can only arise from transitive projective automorphisms. Furthermore, we prove that such construction is feasible for arbitrarily large dimension by exhibiting an infinite class of projectively primitive polynomials whose companion matrix can be used to define a full orbit sequence over an affine space.
Gap junction remodelling and conduction abnormalities in the heart
Creators: name: Chowdhury, Rasheda Amin
Publisher: name: Imperial College London
Year: 2011

description: Electrical coupling between mammalian cardiac myocytes allows orderly spread of excitation and is mediated by gap junction (GJ) channels composed of connexin (Cx) proteins. In normal myocardium, gap junctions within the intercalated disc allow intercellular transfer of ions and represent low resistance pathways for electrical propagation. GJ remodelling describes either a change in connexin expression and/or redistribution toward the lateral cell borders. This remodelling is thought to play a crucial role in arrhythmogenesis. Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. AF becomes more persistent over time (“AF begets AF”). This self perpetuating nature of AF is poorly understood and may be associated with GJ remodelling. The aim of this thesis was to characterise the GJ structural remodelling that occurs alongside electrical changes in AF and to investigate the role of gap junction modulation on changes in electrical propagation, using animal and cell models. The findings of the in vivo goat burst-pacing model suggest that late AF-induced electrical remodelling occurs with a similar time course to connexin remodelling. These consistencies in the timescale of remodelling suggest that structural GJ remodelling is a likely determinant of the development of persistent AF. Although electrical remodelling is unaffected by the angiotensin receptor blocker, candesartan, its administration does attenuate GJ remodelling. HL-1 is a cardiac muscle cell line with a phenotype that is similar to atrial myocytes, particularly in connexin expression. Rapid pacing did not induce a change in the pattern of activation. GJ uncoupling with carbenoxolone resulted in reversible slowing of conduction and could be used as a method of modifying conduction. This thesis provides an insight into the role of gap junctions in conduction propagation both in the intact myocardium in an animal model of AF and in an in vitro cell model.
Oral history interview with Lucius D. Clay, 1971
Publisher: name: Columbia University
Year: 2020
Subjects: Government executives--United States
Veterans
Military education
Military engineering
New Deal, 1933-1939
Depressions--1929--United States

description: Alexander Stephen Clay: political career, United States Senate, 1897- 1915; Europe, 1919; Marietta, Georgia politics, the Negro vote during early 1900s; West Point, 1914-21, 1924-28; military training, instructorship; beginning of Reserve Officers Training Corps; assignment to Panama, mapping the terrain; Rivers and Harbors Division; the Depression in Pittsburgh; effect of New Deal, Works Progress Administration policies on Rivers and Harbors; Franklin D. Roosevelt, Harry Hopkins; Los Angeles Flood Control project; Europe during early 1930s; Tennessee Valley Authority controversy; Harold Ickes; flood control bill in early 1930s; Douglas MacArthur; duty in the Philippines; building Denison Dam, Texas; Sam Rayburn
Foundations for Behavioural Model Elaboration Using Modal Transition Systems
Creators: name: Fischbein, Dario
Publisher: name: Imperial College London
Year: 2011

description: Modal Transition Systems (MTS) are an extension of Labelled Transition Systems (LTS) that have been shown to be useful to reason about system behaviour in the context of partial information. MTSs distinguish between required, proscribed and unknown behaviour and come equipped with a notion of refinement that supports incremental modelling where unknown behaviour is iteratively elaborated into required or proscribed behaviour. A particularly useful notion in the context of software and requirements engineering is that of “merge”. Merging two consistent models is a process that should result in a minimal common refinement of both models where consistency is defined as the existence of one common refinement. One of the current limitations of MTS merging is that a complete and correct algorithm for merging has not been developed. Hence, an engineer attempting to merge partial descriptions may be prevented to do so by overconstrained algorithms or algorithms that introduce behaviour that does not follow from the partial descriptions being merged. In this thesis we study the problems of consistency and merge for the existing MTSs semantics - strong and weak semantics - and provide a complete characterization of MTS consistency as well as a complete and correct algorithm for MTS merging using these semantics. Strong and weak semantics require MTS models to have the same communicating alphabet, the latter allowing the use of a distinguished unobservable action. In this work we show that the requirement of fixing the alphabet for MTS semantics and the treatment of observable actions are limiting if MTSs are to support incremental elaboration of partial behaviour models. We present a novel observational semantics for MTS, branching alphabet semantics, inspired by branching LTS equivalence, which supports the elaboration of model behaviour including the extension of the alphabet of the system to describe behaviour aspects that previously had not been taken into account. Furthermore, we show that some unintuitive refinements allowed by weak semantics are avoided, and prove a number of theorems that relate branching refinement with alphabet refinement and consistency. These theorems, which do not hold for other semantics, support the argument for considering branching alphabet as a sound semantics to support behaviour model elaboration.
Asymptotic Analysis for Markovian models in non-equilibrium Statistical Mechanics
Creators: name: Ottobre, Michela
Publisher: name: Imperial College London
Year: 2011

description: This thesis is mainly concerned with the problem of exponential convergence to equilibrium for open classical systems. We consider a model of a small Hamiltonian system coupled to a heat reservoir, which is described by the Generalized Langevin Equation (GLE) and we focus on a class of Markovian approximations to the GLE. The generator of these Markovian dynamics is an hypoelliptic non-selfadjoint operator. We look at the problem of exponential convergence to equilibrium by using and comparing three different approaches: classic ergodic theory, hypocoercivity theory and semiclassical analysis (singular space theory). In particular, we describe a technique to easily determine the spectrum of quadratic hypoelliptic operators (which are in general non-selfadjoint) and hence obtain the exact rate of convergence to equilibrium.
The Transcription Factor ERG is a Gatekeeper of Endothelial Cell Homeostasis
Creators: name: Dryden, Nicola Helen
Publisher: name: Imperial College London
Year: 2012

description: Endothelial cells (EC) maintain homeostasis through the tightly controlled balance between expression of protective genes and repression of pro-inflammatory genes, and loss of this balance can cause endothelial dysfunction, leading to inflammatory diseases including atherosclerosis. We have previously shown that the ETS transcription factor Erg is involved in maintaining EC homeostasis through transactivation of genes involved in key functions including angiogenesis, migration and survival. In addition to the role for Erg as a transcriptional activator, recent genome wide gene expression analysis has also highlighted a role for Erg in the repression of multiple pro-inflammatory genes. In this Thesis I describe a novel mechanism for Erg-mediated repression of these pro-inflammatory genes using ICAM-1 as a model. We identify two ETS binding sites (EBS) within the ICAM-1 promoter (EBS-118 and -181) which are required for Erg mediated repression. One of these EBS is within a functional NF-κB binding site. We show that the increase in ICAM-1 expression upon Erg inhibition is NF-κB dependent, and that Erg prevents NF-κB p65 from binding to the ICAM-1 promoter, suggesting a direct mechanism of interference. Gene Set Enrichment Analysis (GSEA) of transcriptome profiles of Erg and NF-κB dependent genes, together with chromatin immunoprecipitation (ChIP) studies, reveals that this mechanism is common to other pro-inflammatory genes, including cIAP2 and IL8. We investigate the role of chromatin modifying enzymes and histone modifications in Erg-mediated repression and show that in quiescent EC the ICAM-1 promoter is also bound by the histone methyltransferase ESET, and by HDAC1, both indicators of a repressed chromatin structure. Moreover, in silico data on histone modifications suggest that in quiescent EC the ICAM-1 promoter is in a repressed conformation. The results from this Thesis suggest that Erg acts as a gatekeeper to inhibit transactivation of pro-inflammatory genes in quiescent EC, providing an important barrier to protect against inappropriate endothelial activation.
DIGITAL ECONOMY
Creators: name: Torayev Erkin Eshkabilovich
Publisher: name: Zenodo
Year: 2024

description:  ANNOTATION

 The article analyzes trends in the socio-economic life of the society as a result of the development of the digital economy.  The digital economy is formed due to the improvement of the means of production with a new important element - an automated (digital) control unit.  This has led to significant changes in people's economic activities.

 Key words: digital economy, labor tools, economic activity, goal setting, qualification.
Casimir effect for a dilute dielectric ball at finite temperature
Creators: name: Nesterenko, V. V.
name: Lambiase, G.
name: Scarpetta, G.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The Casimir effect at finite temperature is investigated for a dilute dielectric ball; i.e., the relevant internal and free energies are calculated. The starting point in this study is a rigorous general expression for the internal energy of a system of noninteracting oscillators in terms of the sum over the Matsubara frequencies. Summation over the angular momentum values is accomplished in a closed form by making use of the addition theorem for the relevant Bessel functions. For removing the divergences the renormalization procedure is applied that has been developed in the calculation of the corresponding Casimir energy at zero temperature. The behavior of the thermodynamic characteristics in the low and high temperature limits is investigated.
description: 15 pages, REVTeX, no figures, no tables; editor corrections are introduced, version published in Phys. Rev. D 15
MOESM1 of Galectin-3 Ablation Enhances Liver Steatosis, but Attenuates Inflammation and IL-33-Dependent Fibrosis in Obesogenic Mouse Model of Nonalcoholic Steatohepatitis
Creators: name: Jeftic, Ilija
name: Jovicic, Nemanja
name: Pantic, Jelena
name: Nebojsa Arsenijevic
name: Lukic, Miodrag
name: Pejnovic, Nada
Publisher: name: figshare
Year: 2015
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Supplementary material, approximately 4116 KB.
New Bias Correction Methods for Simulating Precipitation and Runo
Creators: name: White, Rachel Helen
Publisher: name: Imperial College London
Year: 2012

description: Climate change is a huge environmental issue that our society currently faces. This thesis develops and tests two bias correction methods for regional climate simulations of precipitation and runoff . Biases in the soil water physics are corrected by including new physics in the soil moisture parameterisation and the regional model inputs are corrected statistically. Case studies are performed on the Olifants River basin in the Limpopo region of South Africa using the Weather Research and Forecasting (WRF) regional climate model. Accurate knowledge of water availability in this water-stressed region is of great importance for adaptation and future water policy development. The concept of tightly bound water, in which a reservoir of soil water is held stationary within small soil pores but is still available for evapotranspiration, is parameterised for the first time within the land surface scheme of a regional atmosphere-land surface model. Results of a WRF simulation forced by re- analysis show that the standard NOAH land surface scheme over-estimates mean annual runoff by 120% with respect to observations, despite rainfall and atmospheric conditions similar to observed. Use of the tightly bound water scheme within the NOAH model reduces this bias to 22%. Simulations with the WRF model forced with 1980s and 2040s CCSM3.0 general circulation model data show that the tightly bound water scheme significantly reduces runoff in different climates. The new scheme projects a 10% decrease in runoff by the 2040s compared to a 4% decrease projected by the standard model. A new quantile-mapping bias-correction of inputs to regional climate models is proposed. Linear correction and quantile-mapping methods are implemented to correct CCSM3.0 data using re-analysis. Simulation results show a significant difference between the correction methods. The results indicate that the quantile-mapping correction method could be developed to help produce more accurate regional climate predictions for impact studies.
Local Fractional Supersymmetry for Alternative Statistics
Creators: name: Fleury, N.
name: de Traubenberg, M. Rausch
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: A group theory justification of one dimensional fractional supersymmetry is proposed using an analogue of a coset space, just like the one introduced in $1D$ supersymmetry. This theory is then gauged to obtain a local fractional supersymmetry {\it i.e.} a fractional supergravity which is then quantized {\it à la Dirac} to obtain an equation of motion for a particle which is in a representation of the braid group and should describe alternative statistics. A formulation invariant under general reparametrization is given, by means of a curved fractional superline.
description: 15 pages, latex, no figure
Building a Circuit Breaker Mechanism Using .NET
Creators: name: Sabbag Filho, Nagib
Publisher: name: Zenodo
Year: 2025
Subjects: Circuit Breaker
.NET
Resilience
Design patterns

description: The article presents a practical approach to implementing the Circuit Breaker pattern in .NET applications using the Polly library. The Circuit Breaker is a technique that increases the system's resilience by preventing cascading failures caused by external services. Through code examples, the text demonstrates how to install and configure Polly, create Circuit Breaker policies, and test their functionality.
Observations of Two Successive EUV Waves and their Mode Conversion
Creators: name: Chandra, R.
name: Chen, P. F.
name: Joshi, R.
name: Joshi, B.
name: Schmieder, B.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: In this paper, we present the observations of two successive fast-mode extreme ultraviolet (EUV) wave events observed on 2016 July 23. Both fast-mode waves were observed by the Atmospheric Imaging Assembly (AIA) instrument on board the Solar Dynamics Observatory (SDO) satellite, with a traveling speed of ~ 675 and 640 km/s, respectively. These two wave events were associated with two filament eruptions and two GOES M-class solar flares from the NOAA active region 12565, which was located near the western limb. The EUV waves mainly move toward the south direction. We observed the interaction of the EUV waves with a helmet streamer further away in the south. When either or one of the EUV waves penetrates into the helmet streamer, a slowly propagating wave with a traveling speed of ~ 150 km/s is observed along the streamer. We suggest that the slowly-moving waves are slow-mode waves, and interpret this phenomenon as the magnetohydrodynamic (MHD) wave mode conversion from the fast mode to the slow mode. Besides, we observed several stationary fronts in the north and south of the source region.
description: 17 pages, 9 figures, Accepted for publication in ApJ
MOESM1 of Time to death and risk factors among tuberculosis patients in Northern Ethiopia
Creators: name: Asgedom, Solomon
name: Tesfaye, Daniel
name: Yirga Nirayo
name: Tesfay Atey
Publisher: name: figshare
Year: 2018
Subjects: subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Computational Biology

description: Additional file 1. Additional figures.
Type Systems for Coordination Languages
Creators: name: Cai, Haoxuan
Publisher: name: Imperial College London
Year: 2012

description: S-Net is a declarative coordination language rooted in stream processing with a runtime that automatically distributes the computational units among available resources. It is conceived in response to the change of processor development trend, from making the speed faster to embedding more cores. For performance reasons, the S-Net compiler is responsible for generating some additional information, through type inference, which is used by the runtime to make data delivery decisions. This requires the compiler to be supported by a sound type system which can ensure that the program behaviour meets the expectations of the language designers and the programmers. However, due to S-Net's design principle of ease of use, the S-Net type system was believed to be simple and was only informally documented. As we empirically tested the type inference implementation, we gradually revealed the hidden complexity of the calculus behind the apparently easy-to-use language, which was clearly beyond the capability of the informal type system. We then attempted several formulations of the type system, each addressing more issues we have found, but a complete solution was still missing. S-Net now urgently needs a formal type system with proofs of soundness. We have identified a major issue which has been making it difficult to design a correct type system, that is the type-semantics interdependency. In this thesis, we present a new design of the S-Net semantics and type system with no type-semantics interdependency, in terms of a new language BL-Net, a reduced S-Net which preserves only the type-related behaviour, which has an operational semantics reflecting that of S-Net, and a type system with the soundness and completeness proof. Our contributions also include a bridging solution to fit the new type system into the existing compiler structure.
Ca II Triplet Spectroscopy of Giants in SMC Star Clusters: Abundances, Velocities and the Age-Metallicity Relation
Creators: name: Da Costa, G. S.
name: Hatzidimitriou, D.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We have obtained spectra at the Ca II triplet of individual red giants in seven SMC star clusters whose ages range from ~4 to 12 Gyr. The spectra have been used to determine mean abundances for six of the star clusters to a typical precision of 0.12 dex. When combined with existing data for other objects, the resulting SMC age-metallicity relation is generally consistent with that for a simple model of chemical evolution, scaled to the present-day SMC mean abundance and gas mass fraction. Two of the clusters (Lindsay 113 and NGC 339), however, have abundances that ~0.5 dex lower than that expected from the mean age-metallicity relation. It is suggested that the formation of these clusters, which have ages of ~5 Gyr, may have involved the infall of uneriched gas, perhaps from the Magellanic Stream. The spectra also yield radial velocities for the seven clusters. The resulting velocity dispersion is 16 +/- 4 km/sec, consistent with those of the SMC planetary nebula and carbon star populations.
description: 28 pages including 4 figures
Oral history interview with Lucy Komisar, 2001
Publisher: name: Columbia University
Year: 2021
Subjects: Women journalists
Civil rights movements--History--20th century.--United States
Civil rights demonstrations--United States
Second-wave feminism

description: In this interview with Sheila Michaels, Lucy Komisar discusses her awakening to issues of race, her involvement with civil rights organizations, her parent's reaction to her involvement in the civil rights movement, her college experience, and involvement in the feminist movement. Komisar recounts her involvement with the Congress of Racial Equality (CORE), the National Association for the Advancement of Colored People (NAACP), the Student Nonviolent Coordinating Committee (SNCC) and the National Student Association (NSA). Komisar participated in sit-ins at Woolworth's, Beth-El hospital, and ABC/Paramount in New York City. Komisar was a participant in the Route 40 Freedom Rides, attended the founding conference for SNCC at Shaw University in 1960, and the NSA Congress in the summer of 1962. Komisar worked on the student newspaper in both high school and college. She discusses planning a career as a language teacher after realizing that gender discrimination would keep her from pursuing her interest in journalism. Komisar discusses the details of how the Mississippi Free Press was run, its location and the support received from the community and its subscription and distribution process. Komisar also discusses changes within the civil rights movement in the mid to late 1960s. She describes how she became more attuned to discrimination against women and developed an interest in foreign policy and international human rights
Carbon Fibre Reinforced Poly(vinylidene Fluoride)
Creators: name: Shamsuddin, Siti Rosminah
Publisher: name: Imperial College London
Year: 2012

description: The demand for oil in the world is expected to rise by 1.7% in the fourth quarter of 2012 compared to fourth quarter of 2011. In order to cater for this increasing demand, the oil and gas industry continues to explore and develop deep-sea oilfields where oil and gas risers and pipelines encounter extreme conditions. The combination of high pressure and temperature with aggressive media which contains of hydrocarbon, alkanes, acids, sour gas (H2S), and CO2, etc., requires superior material performance and durability. Conventional engineering materials, such as steel are heavy and require corrosion protection, which are currently used as risers, flowlines and choke and kill lines have reached their limits. This is because of the poor chemical resistance and damage tolerance and the high costs involved in supporting their own weight. This has motivated the industry to explore non-corroding and lighter alternative materials if deeper sea reservoirs are to be explored. One such material that has the potential to overcome such limitations thus enabling new design strategies for cost effective, weight and energy saving materials is fibre reinforced composites. The remarkable properties and the tailorability of fibre reinforcement along load paths to achieve excellent performance of the composites is an attribute not found in any other material. The aim of this research was to manufacture novel carbon fibre reinforced polyvinylidene fluoride (PVDF) composites by incorporating atmospheric plasma fluorination of the carbon fibres. Powder impregnation method was adapted for the manufacturing of continuous unidirectional (UD) carbon fibre reinforced PVDF composite prepregs. The resulting composite laminates were characterised through various macro-mechanical tests. The impact of atmospheric plasma fluorination of the carbon fibre on the tensile, flexural, short beam shear and tearing properties of the UD composites were investigated to determine whether the improvements observed in the single fibre model composite can be translated to macro-level composite laminates. Apart from this, the impact of combining both fibre and matrix modifications on the composite were studied and the preliminary results on micro-mechanical scale are presented. Finally, composite pipe structures, made by filament winding technique using unidirectional carbon fibre reinforced PVDF composite prepregs onto a pure PVDF liner were fabricated, and characterised with respect to its mechanical properties.
Non-Abelian Born-Infeld Action and Solitons for Critical Non-BPS Branes
Creators: name: Lambert, N. D.
name: Sachs, I.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The non-abelian flat directions in the tachyon potential of stable non-BPS branes recently found are shown to persist to all orders in alpha' at tree level in the string coupling. We also obtain the non-abelian Born-Infeld action including the tachyon potential for a stack of stable non-BPS branes on a critical orbifold. Finally we discuss stable soliton states on the non-BPS brane.
description: 12+1 pages, Latex. Typos, a reference and the discussion of the monopole solution are corrected
Composition Portfolio - David Morissette
Creators: Morissette, David E.N.
Publisher: name: University of Alberta Library
Year: 2025

This portfolio contains David Morissette's most substantial musical works of 2023-2025, all written during his time in the Master of Music program at the University of Alberta.

Audio and a video of the composition performances can be found here: https://ualberta.aviaryplatform.com/r/rv0cv4dv5g
Additional file 3: of Estimating bacteria diversity in different organs of nine species of mosquito by next generation sequencing
Creators: name: M Mancini
name: C Damiani
name: A Accoti
name: M Tallarita
name: E Nunzi
name: A Cappelli
name: J Bozic
name: R Catanzani
name: P Rossi
name: M Valzano
name: A Serrao
name: I Ricci
name: R Spaccapelo
name: G Favia
Publisher: name: figshare
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Table S1. Percentage of phyla OTUs in the reproductive organs (A) salivary glands (B) and guts (C). (DOCX 47 kb)
Novel EDTA-Ligands Containing an Integral Perylene Bisimide (PBI) Core as Optical Reporter Unit
Creators: name: Marcia, Mario
name: Singh, Prabhpreet
name: Hauke, Frank
name: Maggini, Michele
name: Hirsch, Andreas
Publisher: name: arXiv
Year: 2018
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: The synthesis, characterization and metal complexation of a new class of perylene bisimides (PBIs) being an integral part of ethylenediaminetetraacetic acid (EDTA) is reported. The simplest representative, namely derivative 1a, was synthesized both by a convergent as well as a direct approach while the elongated derivatives, 1b and 1c, were obtained only via a convergent synthetic pathway. All these new prototypes of water-soluble perylenes are bolaamphiphiles and were fully characterized by 1H- and 13C-NMR spectroscopy, matrix assisted laser desorption ionization, time of flight (MALDI-TOF) mass spectrometry and IR spectroscopy. In order to acquaint for the behaviour in solution of our PBIs bearing dentritic wedges, the simplest derivative, 1a, was chosen and tested by means of UV/Vis and fluorescence spectroscopy as well as by zeta-potential measurements. A photoexcitation induced intramolecular photo-electron transfer (PET) can be observed in these molecules. Therefore potential applications as sensor can be imagined. Model compound 1a efficiently coordinates trivalent metal cations both in water and in dimethyl sulfoxide (DMSO). Significantly, the effects of the complexation strongly depend on the aggregation state of the PBI molecules in solution. As a matter of fact, in water, the presence of M3+ ions triggers the formation of light emitting supramolecular aggregates (excimers). On the other hand, in DMSO-rich solutions metal complexation leads to the suppression of the PET and leads to a strong fluorescence enhancement.