cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Peer Reviewing the Rule of Law? A New Mechanism to Safeguard EU Values
Creators: name: Conzelmann, Thomas
Publisher: name: European Papers (www.europeanpapers.eu)
Year: 2022
Subjects: subject: rule of law
subject: peer review
subject: compliance
subject: European Union
subject: article 7
subject: backsliding

description: European Papers - A Journal on Law and Integration, 2022 7(2), 671-695
description: I. Situating the topic. - II. Dealing with rule transgressions. - II.1. Instrumentalist and normative approaches. - II.2. The potential of peer reviews. - III. What is wrong with the current approaches? - III.1. The Article 7 procedure and the rule of law framework. - III.2. The budget conditionality mechanism. - III.3. The Commission Rule of Law Report. - III.4. The Council's annual Rule of Law Dialogue. - IV. The EU Rule of Law Peer Review. - IV.1. History of the initiative. - IV.2. Which institutional design for the initiative? - IV.3. Can the EU peer review address the problems of the approaches? - V. Ways ahead?
description: The possible remedies that the EU can use against backsliding on the rule of law are limited: While art. 7 TEU has been widely conceived as ineffective, the recently introduced budget conditionality may become bogged down in court cases. Softer instruments like the Commission Rule of Law Report provide observations on rule of law developments, but are in themselves unable to address transgressions. Against this background, the Council has recently introduced a peer review mechanism that may exert peer and public pressure on transgressors. However, the agreed procedures show important deficits such as lacking transparency to the outside world, limited time devoted to the re-view, and the absence of clear country-specific recommendations that could become the focus of peer and public pressure. The new procedure thus needs reform to achieve results. A comparison with peer reviews among states in other international organizations show the potential that peer reviewing holds.
Condition-based maintenance with imperfect inspection for a multi-state system subject to competing and hidden failures
Creators: name: Yanjing Zhang
name: Linhan Ouyang
name: Xiaohua Meng
Publisher: name: Zenodo
Year: 2022

description: Code_ECR.m is used to generate the expected cost rates under different parameter settings (Figures 7-10; Tables 4-7). monte_carlo.m and monte_carlo_F.m are subprograms involved in Code_ECR.m. Code_MV.m is used to valiate the proposed model (Figures 13 and 14).
Asplenium escaleroense Christ, Hedwigia
Creators: name: Kessler, Michael
name: Smith, Alan R.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Polypodiales
Aspleniaceae
Asplenium
Asplenium escaleroense

description: Asplenium escaleroense Christ, Hedwigia 44: 366. 1905.
 Range:— Colombia to Bolivia (LP).
 Ecology:— Rare; epiphytic, rarely on wet rocks or cliffs near waterfalls, in humid forests; elevation in Bolivia unknown, 100–1200 m elsewhere. In Amazonian Peru, found only in forests on sandy, rather than clayey, soil (Tuomisto & Ruokolainen 1994).
description: Published as part of Kessler, Michael & Smith, Alan R., 2018, Prodromus of a fern flora for Bolivia. XXIX. Aspleniaceae, pp. 259-280 in Phytotaxa 344 (3) on pages 259-280, DOI: 10.11646/phytotaxa.344.3.6, http://zenodo.org/record/13720625
On the structure of subsets of an orderable group with some small doubling properties
Creators: name: Freiman, G. A.
name: Herzog, M.
name: Longobardi, P.
name: Maj, M.
name: Plagne, A.
name: Robinson, D. J. S.
name: Stanchescu, Y. V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Group Theory (math.GR)
subject: Combinatorics (math.CO)
subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11P70, 20F05, 20F99, 11B13, 05E15

description: The aim of this paper is to present a complete description of the structure of subsets S of an orderable group G satisfying |S^2| = 3|S|-2 and is non-abelian.
Asplenium feei Fee, Mem. Foug.
Creators: name: Kessler, Michael
name: Smith, Alan R.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Polypodiales
Aspleniaceae
Asplenium
Asplenium feei

description: Asplenium feei Kunze ex Fée, Mém. Foug. 5: 194. 1852.
 Range:— Antilles; southern Mexico to Bolivia (BE, CO, LP) and Brazil.
 Ecology:— Uncommon; epiphytic, sometimes terrestrial, in humid forests; 950–2000 m (down to sea level elsewhere). This is one of several fern species that are limited to mountain forests in Bolivia but reach the lowlands in more humid regions such as western Amazonia or the Colombian Choco region (Kessler 2001), indicating that their lower elevational distribution is determined by water availability rather than temperature (Kluge et al. 2006).
 Notes:— Perhaps conspecific with African A. anisophyllum Kunze (Smith 1993, Moran & Smith 2001).
description: Published as part of Kessler, Michael & Smith, Alan R., 2018, Prodromus of a fern flora for Bolivia. XXIX. Aspleniaceae, pp. 259-280 in Phytotaxa 344 (3) on pages 259-280, DOI: 10.11646/phytotaxa.344.3.6, http://zenodo.org/record/13720625
title: Beyond the Rule of Law Conditionality: Exploiting the EU Spending Power to Foster the Union's Values
Creators: name: Fisicaro, Marco
Publisher: name: European Papers (www.europeanpapers.eu)
Year: 2022
Subjects: subject: EU budget
subject: EU values
subject: rule of law crisis
subject: conditionality
subject: European Structural and Investment Funds
subject: Next Generation EU

description: European Papers - A Journal on Law and Integration, 2022 7(2), 697-719
description: I. Introduction. - II. Protecting EU values through ESI funds: The new fundamental rights "enabling conditions". - III. Decentralising the "politics of values": The potential of the Justice, Rights and Values Fund. - IV. The Recovery and Resilience Facility: Shaping Europe's recovery in line with EU values. - V. Conclusions.
description: In recent years, the EU budget has emerged as an attractive instrument to foster compliance with the fundamental values enshrined in art. 2 TEU. Especially following the exceptional increase in EU expenditure, the power of the purse seems to provide indeed more persuasive arguments compared with the existing EU rule-of-law toolbox. While most of the attention has focused exclusively on the rule-of-law conditionality regime ultimately introduced with Regulation (EU, Euratom) 2020/2092, this Article argues that the EU budget offers further, and arguably more promising, avenues to protect, promote and enforce the EU common values through financial means. Most notably, this Article explores the potential and challenges of the EU budget as a values-oriented policy instrument focus-ing on three elements of the new budgetary framework: i) the set of fundamental rights "enabling conditions" attached to the European Structural and Investment Funds, among which stands out an horizontal enabling condition related to the EU Charter of Fundamental Rights; ii) the "Justice, Rights and Values Fund", with special attention to the reforms concerning the financing of civil society organisations; iii) the "Recovery and Resilience Facility", which provides valuable instruments to police compliance with rule of law and fundamental rights standards thanks to its connection with the European Semester and the European Pillar of Social Rights.
Semi-analytical approach to criteria for ignition of excitation waves
Creators: name: Bezekci, B.
name: Idris, I.
name: Simitev, R. D.
name: Biktashev, V. N.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Pattern Formation and Solitons (nlin.PS)
subject: FOS: Physical sciences

description: We consider the problem of ignition of propagating waves in one-dimensional bistable or excitable systems by an instantaneous spatially extended stimulus. Earlier we proposed a method (Idris and Biktashev, PRL, vol 101, 2008, 244101) for analytical description of the threshold conditions based on an approximation of the (center-)stable manifold of a certain critical solution. Here we generalize this method to address a wider class of excitable systems, such as multicomponent reaction-diffusion systems and systems with non-self-adjoint linearized operators, including systems with moving critical fronts and pulses. We also explore an extension of this method from a linear to a quadratic approximation of the (center-)stable manifold, resulting in some cases in a significant increase in accuracy. The applicability of the approach is demonstrated on five test problems ranging from archetypal examples such as the Zeldovich--Frank-Kamenetsky equation to near realistic examples such as the Beeler-Reuter model of cardiac excitation. While the method is analytical in nature, it is recognised that essential ingredients of the theory can be calculated explicitly only in exceptional cases, so we also describe methods suitable for calculating these ingredients numerically.
description: 31 page, 20 figures, as resubmitted to Phys Rev E on 2015/09/20 and accepted on 2015/09/22
Hyperbranched polymer stars with Gaussian chain statistics revisited
Creators: name: Polinska, P.
name: Gillig, C.
name: Wittmer, J. P.
name: Baschnagel, J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Conformational properties of regular dendrimers and more general hyperbranched polymer stars with Gaussian statistics for the spacer chains between branching points are revisited numerically. We investigate the scaling for asymptotically long chains especially for fractal dimensions $d_f = 3$ (marginally compact) and $d_f = 2.5$ (diffusion limited aggregation). Power-law stars obtained by imposing the number of additional arms per generation are compared to truly self-similar stars. We discuss effects of weak excluded volume interactions and sketch the regime where the Gaussian approximation should hold in dense solutions and melts for sufficiently large spacer chains.
description: 13 pages, 14 figures
Predicting clinical outcome from reward circuitry function and white matter structure in behaviorally and emotionally dysregulated youth
Creators: name: Bonar,
name: Sunshine,
name: Horwitz,
name: Phillips,
name: Forbes,
name: Iyengar,
name: Travis,
name: Holland,
name: Bertocci,
name: Fournier,
name: Versace,
name: Fristad,
name: Almeida,
name: Bebko,
name: Gill,
name: Frazier,
name: Schirda,
name: Perlman,
name: Arnold,
name: Findling,
name: Diwadkar,
name: Axelson,
name: Youngstrom,
name: Birmaher,
name: Kowatch,
name: Olino,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Behavioral and emotional dysregulation in childhood may be understood as prodromal to adult psychopathology. Additionally, there is a critical need to identify biomarkers reflecting underlying neuropathological processes that predict clinical/behavioral outcomes in youth. We aimed to identify such biomarkers in youth with behavioral and emotional dysregulation in the Longitudinal Assessment of Manic Symptoms (LAMS) study. We examined neuroimaging measures of function and white matter in the whole brain using 80 youth aged 14.0(sd=2.0) from 3 clinical sites. Linear regression using the LASSO method for variable selection was used to predict severity of future behavioral and emotional dysregulation [measured by the Parent General Behavior Inventory-10 Item Mania Scale (PGBI-10M)] at a mean of 14.2 months follow-up after neuroimaging assessment. Neuroimaging measures, together with near-scan PGBI-10M, a score of manic behaviors, depressive behaviors, and sex, explained 28% of the variance in follow-up PGBI-10M. Neuroimaging measures alone, after accounting for other identified predictors, explained approximately one-third of the explained variance, in follow-up PGBI-10M. Specifically, greater bilateral cingulum length predicted lower PGBI-10M at follow-up. Greater functional connectivity in parietal-subcortical reward circuitry predicted greater PGBI-10M at follow-up. For the first time, data suggest that multimodal neuroimaging measures of underlying neuropathologic processes account for over a third of the explained variance in clinical outcome in a large sample of behaviorally and emotionally dysregulated youth. This may be an important first step toward identifying neurobiological measures with the potential to act as novel targets for early detection and future therapeutic interventions.
Eigenvector dynamics under perturbation of modular networks
Creators: name: Sarkar, Somwrita
name: Chawla, Sanjay
name: Robinson, Peter A.
name: Fortunato, Santo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Information Retrieval (cs.IR)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Rotation dynamics of eigenvectors of modular network adjacency matrices under random perturbations are presented. In the presence of $q$ communities, the number of eigenvectors corresponding to the $q$ largest eigenvalues form a "community" eigenspace and rotate together, but separately from that of the "bulk" eigenspace spanned by all the other eigenvectors. Using this property, the number of modules or clusters in a network can be estimated in an algorithm-independent way. A general argument and derivation for the theoretical detectability limit for sparse modular networks with $q$ communities is presented, beyond which modularity persists in the system but cannot be detected. It is shown that for detecting the clusters or modules using the adjacency matrix, there is a "band" in which it is hard to detect the clusters even before the theoretical detectability limit is reached, and for which the theoretically predicted detectability limit forms the sufficient upper bound. Analytic estimations of these bounds are presented, and empirically demonstrated.
description: 7 pages, 4 figures
Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans
Creators: name: Feitosa,
name: Kardia,
name: Schick,
name: Olfson,
name: Van Duijn,
name: Franco,
name: Amin,
name: Breslau,
name: Culverhouse,
name: Hetrick,
name: Brown,
name: Vojinovic,
name: Foltz,
name: Fox,
name: Uitterlinden,
name: Ridker,
name: Gogarten,
name: Fox,
name: Laurie,
name: Bartz,
name: Hatsukami,
name: Rice,
name: Goate,
name: Johnson,
name: Grove,
name: Chen,
name: Rose,
name: Reiner,
name: Arnett,
name: Franceschini,
name: Ware,
name: Marosy,
name: Borecki,
name: Wang,
name: Zhao,
name: Stitzel,
name: Morrison,
name: Guo,
name: Rao,
name: Bertelsen,
name: Barr,
name: Bierut,
name: Saccone,
name: Hartz,
name: Musani,
name: Psaty,
name: Wilson,
name: Rice,
name: Hofman,
name: Doheny,
name: Chasman,
name: Schwander,
name: Yao,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The common nonsynonymous variant rs16969968 in the α5 nicotinic receptor subunit gene (CHRNA5) is the strongest genetic risk factor for nicotine dependence in European Americans and contributes to risk in African Americans. To comprehensively examine whether other CHRNA5 coding variation influences nicotine dependence risk, we performed targeted sequencing on 1582 nicotine dependent cases (Fagerström Test for Nicotine Dependence score≥4) and 1238 non-dependent controls, with independent replication of common and low frequency variants using 12 studies with exome chip data. Nicotine dependence was examined using logistic regression with individual common variants (MAF≥0.05), aggregate low frequency variants (0.05>MAF≥0.005), and aggregate rare variants (MAF<0.005). Meta-analysis of primary results was performed with replication studies containing 12 174 heavy and 11 290 light smokers. Next-generation sequencing with 180X coverage identified 24 nonsynonymous variants and 2 frameshift deletions in CHRNA5, including 9 novel variants in the 2820 subjects. Meta-analysis confirmed the risk effect of the only common variant (rs16969968, European ancestry: OR=1.3, p=3.5×10−11; African ancestry: OR=1.3, p=0.01) and demonstrated that 3 low frequency variants contributed an independent risk (aggregate term, European ancestry: OR=1.3, p=0.005; African ancestry: OR=1.4, p=0.0006). The remaining 22 rare coding variants were associated with increased risk of nicotine dependence in the European American primary sample (OR=12.9, p=0.01) and in the same risk direction in African Americans (OR=1.5, p=0.37). Our results indicate that common, low frequency and rare CHRNA5 coding variants are independently associated with nicotine dependence risk. These newly identified variants likely influence risk for smoking-related diseases such as lung cancer.
Asplenium flabellulatum Kunze, Linnaea
Creators: name: Kessler, Michael
name: Smith, Alan R.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Polypodiales
Aspleniaceae
Asplenium
Asplenium flabellulatum

description: Asplenium flabellulatum Kunze, Linnaea 9: 71. 1834.
 Range:— Antilles; southern Mexico to Bolivia (BE, CO, LP) and Brazil.
 Ecology:— Common; terrestrial, often on slopes and ravine banks, in humid forests; 650–2400 m (down to sea level elsewhere).
 Notes:— Asplenium radicans L. s.l. (an historically confusing species comprising several distinct taxa), from Mexico to Peru and Brazil, has been cited for Bolivia (Foster 1958), but we have not seen specimens; however, its presence is likely. It has deeply pinnate-pinnatifid to barely 2-pinnate blade dissection intermediate between A. cirrhatum and A. flabellulatum. The rhizome scales are shorter (2–3 vs. 3–5 mm long) and the indusia longer (4–5 vs. 1–4 mm long) than in A. flabellulatum and A. uniseriale.
description: Published as part of Kessler, Michael & Smith, Alan R., 2018, Prodromus of a fern flora for Bolivia. XXIX. Aspleniaceae, pp. 259-280 in Phytotaxa 344 (3) on pages 259-280, DOI: 10.11646/phytotaxa.344.3.6, http://zenodo.org/record/13720625
The ESC/E(Z) complex, an effector of response to ovarian steroids, manifests an intrinsic difference in cells from women with premenstrual dysphoric disorder
Creators: name: Yuan,
name: Martinez,
name: Goldman,
name: Dubey,
name: Schmidt,
name: Schuebel,
name: Nieman,
name: Rubinow,
name: Hoffman,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Clinical evidence suggests that mood and behavioral symptoms in Premenstrual Dysphoric Disorder (PMDD), a common, recently recognized, psychiatric condition among women, reflect abnormal responsivity to ovarian steroids. This differential sensitivity could be due to an unrecognized aspect of hormonal signaling or a difference in cellular response. In this study, lymphoblastoid cell line cultures (LCLs) from women with PMDD and asymptomatic Controls were compared via whole transcriptome sequencing (RNA-seq) during untreated (ovarian steroid-free) conditions and following hormone treatment. The women with PMDD manifested ovarian steroid-triggered behavioral sensitivity during a hormone suppression and add-back clinical trial, and Controls did not, leading us to hypothesize that women with PMDD might differ in their cellular response to ovarian steroids. In untreated LCLs, our results overall suggest a divergence between mRNA (e.g., gene transcription) and protein (e.g., RNA translation in proteins) for the same genes. Pathway analysis of the LCL transcriptome revealed, among others, over-expression of ESC/E(Z) complex genes (an ovarian steroid-regulated gene silencing complex) in untreated LCLs from women with PMDD, with more than half of these genes over-expressed as compared to Controls, and with significant effects for MTF2, PHF19, and SIRT1 (p<0.05). RNA and protein expression of the 13 ESC/E(Z) complex genes were individually quantitated. This pattern of increased ESC/E(Z) mRNA expression was confirmed in a larger cohort by qRT-PCR. In contrast, protein expression of ESC/E(Z) genes was decreased in untreated PMDD LCLs with MTF2, PHF19, and SIRT1 all significantly decreased (p<0.05). Finally, mRNA expression of several ESC/E(Z) complex genes were increased by progesterone in Controls only, and decreased by estradiol in PMDD LCLs. These findings demonstrate that LCLs from women with PMDD manifest a cellular difference in ESC/E(Z) complex function both in the untreated condition and in response to ovarian hormones. Dysregulation of ESC/E(Z) complex function could contribute to PMDD.
Server component installation and testing of the university information and educational environment on the Moodle LMS platform
Creators: name: Erjomina, Irina
name: Rozentsvaig, Aleksandr
name: Ziatdinov, Rushan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Other Computer Science (cs.OH)
subject: FOS: Computer and information sciences

description: The informational educational environment (IEE) of an institution is a complex multilevel system which, along with methodical, organizational and cultural resources, accumulates the intellectual and technical potential of a university, as well as the informative and activity components of the learners and teachers. In practice, the formation of IEE is actually based on the creation of information technologies and their integration into the existing educational environment of the institution. The management of this system is carried out using specialized equipment and software. For the successful formation and operation of IEE, in the present work we review software products that form the basis of the organization of interactive and web interactions between students, teachers and all participants of the educational process. We analyse the technical capabilities that have provided users with IEE services such as the Apache web server with connected modules PHP, MySQL, the Java virtual machine and the Red5 server. We demonstrate the possibility of obtaining results from the interaction of these products, and reports on users' work in webinars, video conferences and web conferences.
description: in Russian
Small-scale magnetic fields of binary stars
Creators: name: Hahlin, Axel
name: Kochukhov, Oleg
name: Pouilly, Kim
Publisher: name: Zenodo
Year: 2023
Subjects: Stars: magnetic fields
binaries: spectroscopic
stars: variables: T Tauri
techniques: spectroscopic

description: This work aims to investigate the small-scale magnetic fields of a pair of binary T Tauri stars, V1878 Ori and V4046 Sgr. This is done in order to provide a more complete picture of their magnetic field, as so far only the large-scale structures have been studied using Zeeman Doppler imaging (ZDI) by Lavail et al. (2020) and Donati et al. (2011) respectively. In addition, the two binaries have very similar components, indicating that the magnetic field generation should be similar for the two components. We use observations taken by ESPaDOnS at the CFHT. In order to study the small scale fields we use Zeeman intensification, an effect that increases the equivalent widths of spectral lines in the presence of magnetic fields. We find that the magnetic fields on the components are similar to each other. This is in contrast to the large-scale fields which show significant difference in both strength and structure. Our results indicate that the small-scale fields is a more stable measure of the magnetic dynamo whereas the large-scale fields of cool stars are prone to variability.
description: {"references": ["Donati, J. F., Gregory, S. G., Montmerle, T. et al. 2011, MNRAS, 417, 1747", "Hahlin, A. & Kochukhov, O. 2022, A&A, 659, A151", "Lavail, A., Kochukhov, O., & Hussain, G. A. J. 2019, A&A, 630, A99", "Lavail, A., Kochukhov, O., Hussain, G. A. J., et al. 2020, MNRAS, 497, 632", "Pouilly, K., Kochukhov, O., K\u00f3sp\u00e1l, A. et al. 2023, MNRAS, 518, 5072"]}
Toward a conceptual framework for early brain and behavior development in autism
Creators: name: Zylka,
name: Elison,
name: Piven,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Studies of infant siblings of older autistic probands, who are at elevated risk for autism, have demonstrated that the defining features of autism are not present in the first year of life but emerge late in the first and into the second year. A recent longitudinal neuroimaging study of high-risk siblings revealed a specific pattern of brain development in infants later diagnosed with autism, characterized by cortical surface area hyper-expansion in the first year followed by brain volume overgrowth in the second year that is associated with the emergence of autistic social deficits. Together with new observations from genetically defined autism risk alleles and rodent model, these findings suggest a conceptual framework for the early, post-natal development of autism. This framework postulates that an increase in the proliferation of neural progenitor cells and hyper-expansion of cortical surface area in the first year, occurring during a pre-symptomatic period characterized by disrupted sensorimotor and attentional experience, leads to altered experience-dependent neuronal development and decreased elimination of neuronal processes. This process is linked to brain volume overgrowth and disruption of the refinement of neural circuit connections and is associated with the emergence of autistic social deficits in the second year of life. A better understanding of the timing of developmental brain and behavior mechanisms in autism during infancy, a period which precedes the emergence of the defining features of this disorder, will likely have important implications for designing rational approaches to early intervention.
New Signatures of the Milky Way Formation in the Local Halo and Inner Halo Streamers in the Era of Gaia
Creators: name: Fiorentin, Paola Re
name: Lattanzi, Mario G.
name: Spagna, Alessandro
name: Curir, Anna
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We explore the vicinity of the Milky Way through the use of spectro-photometric data from the Sloan Digital Sky Survey and high-quality proper motions derived from multi-epoch positions extracted from the Guide Star Catalogue II database. In order to identify and characterise streams as relics of the Milky Way formation, we start with classifying, select, and study $2417$ subdwarfs with $\rm{[Fe/H] < -1.5}$ up to $3$ kpc away from the Sun as tracers of the local halo system. Then, through phase-space analysis, we find statistical evidence of five discrete kinematic overdensities among $67$ of the fastest-moving stars, and compare them to high-resolution N-body simulations of the interaction between a Milky-Way like galaxy and orbiting dwarf galaxies with four representative cases of merging histories. The observed overdensities can be interpreted as fossil substructures consisting of streamers torn from their progenitors, such progenitors appear to be satellites on prograde and retrograde orbits on different inclinations. In particular, of the five detected overdensities, two appear to be associated, yelding twenty-one additional main-sequence members, with the stream of Helmi et al. (1999) that our analysis confirms on a high inclination prograde orbit. The three newly identified kinematic groups could be associated with the retrograde streams detected by Dinescu (2002) and Kepley et al. (2007), whatever their origin, the progenitor(s) would be on retrograde orbit(s) and inclination(s) within the range $10^{\circ} ÷60^{\circ}$. Finally, we use our simulations to investigate the impact of observational errors and compare the current picture to the promising prospect of highly improved data expected from the Gaia mission.
description: 16 pages, 10 figures, 6 Tables. Accepted for publication in The Astronomical Journal
Entry time statistics to different shrinking sets
Creators: name: Cipriano, Italo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics

description: We consider $ψ$-mixing dynamical systems $(\mathcal{X},T,B,μ)$ and we find conditions on families of sets $\{\mathcal{U}_n\subset \mathcal{X}:n\in\mathbb{N}\}$ so that $μ(\mathcal{U}_n)τ_n$ tends in law to an exponential random variable, where $τ_n$ is the entry time to $\mathcal{U}_n.$
Partizipation in der Pflegekinderhilfe: Eine qualitative Forschungsarbeit
Creators: name: Greber, Urs
name: Rüegg, Tabea
Publisher: name: Zenodo
Year: 2022

description: Die Pflegekinderhilfe in der Schweiz ist einem ständigen Wandel ausgesetzt. In der Politik, aber auch in Fachkreisen der Sozialen Arbeit herrscht ein Diskurs darüber, wie die Rahmenbedingungen dieser Kinderschutzmassnahme gestaltet sein müssen, damit den betroffenen Kindern möglichst optimale Entwicklungsmöglichkeiten geboten werden können. Die Erhebung des Forschungsstandes in der Pflegekinderhilfe zeigt, dass die Umsetzung von Partizipation in der Praxis der Schweizer Pflegekinderhilfe nach wie vor zu wenig erforscht ist. Deshalb befasst sich die Forschungsarbeit «Partizipation in der Pflegekinderhilfe» von Tabea Rüegg und Urs Greber mit folgender Fragestellung: «Wie werden die Pflegeeltern, Pflegekinder und Herkunftseltern in der Praxis über den gesamten Prozess eines Pflegeverhältnisses in der Pflegekinderhilfe partizipativ miteinbezogen?» Zur Beantwortung wurden zehn leitfadengestützte Expert*inneninterviews geführt, welche nach Meuser und Nagel ausgewertet wurden. Die Forschungsergebnisse zeigen, dass der Begriff Partizipation von den Beteiligten unterschiedlich wahrgenommen und auch die rechtlichen Rahmenbedingungen unterschiedlich ausgelegt werden. Zudem konnte festgestellt werden, dass Erziehungspartnerschaften auf Augenhöhe zwischen Herkunftseltern, Pflegeeltern und Fachpersonen nicht der untersuchten Praxis entsprechen. Aussagen decken auf, dass unpassende Partizipationsmöglichkeiten überfordernd wirken können. Am Beispiel von Standortgesprächen haben die Autorin und der Autor einen Reflexionsfragebogen für Fachpersonen erstellt, welcher dazu beitragen soll, dass Beteiligte adäquate Partizipationsmöglichkeiten erfahren dürfen.
description: + Code Diss LU: hslusa basa be + Code Diss LU: hslusa basp be + Fussnote: Bachelor-Arbeit, Hochschule Luzern – Soziale Arbeit, Studienrichtung Sozialarbeit & Sozialpädagogik, 2022 + NL-Code: NLLUHSA202209
title: General-Charte von Teutschland; 1821
title: auf der vom Hauptmann Weiland gezeichneten Charte Geognostisch begraenzt
titleType: Subtitle
Creators: name: Keferstein, Christian
name: Weiland, Karl Ferdinand
name: Keferstein, Christian
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2013

description: Maßstab in graph. Form (Deutsche Meilen). - Mit Bergstrichen. - Legende: Geognostischer Atlas. Tafel I. - Als Beil. zu: Teutschland, geognostisch-geologisch dargestellt / hrsg. von Christian Keferstein. - Bd. 1,1 (1821) erschienen
Asplenium formosum Willd., Sp. Pl.
Creators: name: Kessler, Michael
name: Smith, Alan R.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Polypodiales
Aspleniaceae
Asplenium
Asplenium formosum

description: Asplenium formosum Willd., Sp. Pl. 5(1): 329. 1810.
 Range:— Antilles; Mexico to Brazil and Argentina; Africa; Madagascar; southern India and Sri Lanka. In Bolivia, mainly in CH, SC, and TA, with a single record from a dry valley in LP.
 Ecology:— Fairly common, terrestrial and saxicolous, occasionally epiphytic, often on rocks near streams, in semihumid forests; to 1500(2000) m. In Mexico, viable spores have been found in soil spore bank down to at least 30 cm depth (del Rosario Ramírez-Trejo et al. 2004).
 Notes:— Part of the Asplenium monanthes complex (Dyer et al. 2012).
description: Published as part of Kessler, Michael & Smith, Alan R., 2018, Prodromus of a fern flora for Bolivia. XXIX. Aspleniaceae, pp. 259-280 in Phytotaxa 344 (3) on pages 259-280, DOI: 10.11646/phytotaxa.344.3.6, http://zenodo.org/record/13720625
Gaplessness and the Coulomb anomaly in the strongly disordered films of Molybdenum Carbide
Creators: name: Kulkarni, P.
name: Szabo, P.
name: Zemlicka, M.
name: Grajcar, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Gaplessness was observed in the disordered films of MoC on approaching to the superconductor to insulator transition by reducing the film thickness. The gaplessness is attributed to the enhanced Coulomb interactions due to the loss of screening in the presence of strong disorder in the films.
description: 3 pages, 5 figures
A DNA methylation biomarker of alcohol consumption
Creators: name: Liu,
name: Stolk,
name: Hernandez,
name: Prokisch,
name: Kühnel,
name: Wray,
name: Brody,
name: Ferrucci,
name: Visscher,
name: Boer,
name: Lind,
name: Almli,
name: Tsai,
name: Castillo-Fernandez,
name: Bell,
name: Liang,
name: Ding,
name: Huan,
name: McRae,
name: Liu,
name: Trevisi,
name: Wiggins,
name: Marioni,
name: Irvin,
name: Guo,
name: Elks,
name: Wang,
name: Mendelson,
name: Spector,
name: Kretschmer,
name: Yet,
name: Bandinelli,
name: Zhi,
name: Schwartz,
name: Love,
name: Sotoodehnia,
name: Aslibekyan,
name: Baccarelli,
name: Guan,
name: Pfeiffer,
name: Just,
name: Reynolds,
name: Conneely,
name: Waldenberger,
name: Yao,
name: London,
name: Shah,
name: Deary,
name: Gustafsson,
name: North,
name: Binder,
name: Joehanes,
name: Van Meurs,
name: Ressler,
name: Ingelsson,
name: Tanaka,
name: Peters,
name: Levy,
name: Uitterlinden,
name: Lohman,
name: Smith,
name: Ong,
name: Li,
name: Strauch,
name: Duan,
name: Vokonas,
name: Wareham,
name: Herder,
name: Fornage,
name: Sandling,
name: Hedman,
name: Arnett,
name: Absher,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: The lack of reliable measures of alcohol intake is a major obstacle to the diagnosis and treatment of alcohol-related diseases. Epigenetic modifications such as DNA methylation may provide novel biomarkers of alcohol use. To examine this possibility, we performed an epigenome-wide association study of methylation of cytosine-phosphate-guanine dinucleotide (CpG) sites in relation to alcohol intake in 13 population-based cohorts (ntotal=13 317; 54% women; mean age across cohorts 42–76 years) using whole blood (9643 European and 2423 African ancestries) or monocyte-derived DNA (588 European, 263 African and 400 Hispanic ancestry) samples. We performed meta-analysis and variable selection in whole-blood samples of people of European ancestry (n=6926) and identified 144 CpGs that provided substantial discrimination (area under the curve=0.90–0.99) for current heavy alcohol intake (⩾42 g per day in men and ⩾28 g per day in women) in four replication cohorts. The ancestry-stratified meta-analysis in whole blood identified 328 (9643 European ancestry samples) and 165 (2423 African ancestry samples) alcohol-related CpGs at Bonferroni-adjusted P<1 × 10−7. Analysis of the monocyte-derived DNA (n=1251) identified 62 alcohol-related CpGs at P<1 × 10-7. In whole-blood samples of people of European ancestry, we detected differential methylation in two neurotransmitter receptor genes, the γ-Aminobutyric acid-A receptor delta and γ-aminobutyric acid B receptor subunit 1; their differential methylation was associated with expression levels of a number of genes involved in immune function. In conclusion, we have identified a robust alcohol-related DNA methylation signature and shown the potential utility of DNA methylation as a clinically useful diagnostic test to detect current heavy alcohol consumption.
Acute engagement of Gq-mediated signaling in the bed nucleus of the stria terminalis induces anxiety-like behavior
Creators: name: Magness,
name: DiBerto,
name: Hurd,
name: Kash,
name: Falls,
name: Pati,
name: McElligott,
name: Michaelides,
name: Mazzone,
name: Hardaway,
name: Duffy,
name: Tipton,
name: Hammack,
name: Anderson,
name: McKlveen,
name: Fox,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: The bed nucleus of the stria terminalis (BNST) is a brain region important for regulating anxiety-related behavior in both humans and rodents. Here we used a chemogenetic strategy to investigate how engagement of G protein-coupled receptors (GPCR) signaling cascades in genetically defined GABAergic BNST neurons modulates anxiety-related behavior and downstream circuit function. We saw that stimulation of vesicular γ-Aminobutyric acid (GABA) transporter (VGAT)-expressing BNST neurons using hM3Dq, but neither hM4Di nor rM3Ds Designer Receptors Exclusively Activated by a Designer Drug (DREADDs), promotes anxiety-like behavior. Further, we identified that activation of hM3Dq receptors in BNST VGAT neurons can induce a long-term depression (LTD)-like state of glutamatergic synaptic transmission, indicating DREADD-induced changes in synaptic plasticity. Further, we used DREADD-assisted metabolic mapping (DREAMM) to profile brain-wide network activity following activation of Gq-mediated signaling in BNST VGAT neurons and saw increased activity within ventral midbrain structures, including the ventral tegmental area (VTA), and hindbrain structures such as the locus coeruleus (LC) and parabrachial nucleus (PB). These results highlight that Gq-mediated signaling in BNST VGAT neurons can drive downstream network activity that correlates with anxiety-like behavior, and points to the importance of identifying endogenous GPCRs within genetically defined cell populations. We next used a microfluidics approach to profile the receptorome of single BNST VGAT neurons. This approach yielded multiple Gq-coupled receptors that are associated with anxiety-like behavior and several potential novel candidates for regulation of anxiety-like behavior. From this, we identified that stimulation of the Gq-coupled receptor 5-HT2CR in the BNST is sufficient to elevate anxiety-like behavior in an acoustic startle task. Together, these results provide a novel profile of receptors within genetically defined BNST VGAT neurons that may serve as therapeutic targets for regulating anxiety states and provide a blueprint for examining how G-protein mediated signaling in a genetically defined cell type can be used to assess behavior and brain-wide circuit function.
The Orion Star-Formation Complex as a training set for machine learning techniques
Creators: name: Roquette, Julia
name: Audard, Marc
name: Pavlidou, Tatiana
name: Marton, Gabor
name: Hernandez, David
name: Dionatos, Odysseas
name: Gezer, Ilknur
Publisher: name: Zenodo
Year: 2023
Subjects: Star Formation
Low Mass Stars
Data
Young Stellar Objects

description: As the field of star-formation follows astronomy into the era of big data, we are now faced with the challenges behind truly reliable and unbiased applications of artificial intelligence and machine learning techniques. One of these challenges is quantifying the uncertainties behind machine learning applications and evaluating how the uncertainties in our prior knowledge of the field of starformation impact the performance of such algorithms. The Orion star-formation complex is arguably the most well-studied star-forming region in the sky. With more than 8,000 refereed publications indexed by NASA/ADS and about one-tenth of those feeding data products to the CDS database, the region offers a wealth of possible attributes to be explored by machine learning techniques. In this study, we examine the region under the framework of the NEMESIS (New Evolutionary Model for Early stages of Stars with Intelligent Systems) project - which aims to reshape our understanding of star-formation by employing artificial intelligence methods to explore astronomical big-data. Towards benchmarking the Orion complex as a training set for machine learning techniques, we present a synoptic catalogue of Young Stellar Objects in the region. This catalogue combines data from large surveys (e.g., AllWISE, AKARI, Spitzer, Herschel, Gaia EDR3, etc.) with literature data 109 products, covering the whole electromagnetic spectrum from X-rays to radio and has been curated with particular attention to both time-domain and variability aspects.
description: {"references": ["Lada 1987, IAUS, 115, 1", "Andr\u00e9 et al. 1993 ApJ, 206, 122", "Evans et al. 2009, ApJS, 181, 321", "Dunham et al. 2004 PPVI prpl.conf 195", "Fang et al. 2013 ApJS, 207, 5", "Hsu et al. 2012, ApJ, 752, 59", "Newton et al. 2017, ApJ, 834, 85", "Barrado y Navascu\u00e9s & Mart\u00edn 2003, AJ, 126, 2997", "White & Basri 2003, ApJ, 582, 1109"]}
Asplenium hallbergii Mickel & Beitel, Mem.
Creators: name: Kessler, Michael
name: Smith, Alan R.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Polypodiales
Aspleniaceae
Asplenium
Asplenium hallbergii

description: Asplenium hallbergii Mickel & Beitel, Mem. New York Bot. Gard. 46: 58. 1988.
 Range:— Mexico; Venezuela; Peru, Bolivia (CO); probably more widespread.
 Ecology:— Rare; terrestrial or saxicolous in semihumid forests; 3200–3350 m, down to 1500 m elsewhere.
 Notes:— Often bears buds sheathed in black, clathrate scales in the axils of some pinnae (buds usually lacking in the closely related A. monanthes). An apomictic member of the A. monanthes complex (Dyer et al. 2012). May be conspecific with Asplenium wagneri Mett. ex Kuhn (= A. monanthes var. wagneri (Mett. ex Kuhn) Stolze) from Ecuador to central Peru. The Bolivian record of Asplenium extensum Fée by Smith et al. (1999) has now been reidentified as this species.
description: Published as part of Kessler, Michael & Smith, Alan R., 2018, Prodromus of a fern flora for Bolivia. XXIX. Aspleniaceae, pp. 259-280 in Phytotaxa 344 (3) on pages 259-280, DOI: 10.11646/phytotaxa.344.3.6, http://zenodo.org/record/13720625
Clonal Dynamics
Creators: name: Liu, Hao
name: Dotti, Gianpietro
name: Heslop, Helen E
name: Brenner, Malcolm K
name: Dakhova, Olga
name: Wheeler, David A
name: Chang, Edmund C.
name: West, John A
name: Zhou, Xiaoou
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Safety switches are becoming relevant for the clinical translation of T-cell-based immunotherapies. In patients receiving an allogeneic hematopoietic stem cell transplant, the inducible caspase-9 gene (iC9) safety switch expressed by donor-derived T lymphocytes efficiently controls acute graft versus host disease (GvHD). However, in vivo elimination of iC9-T cells by the chemical inducer of dimerization (CID) that activates the iC9 protein is incomplete. To study this effect, we characterized the clonal diversity and dynamics of vector insertion sites (VIS) in iC9-T cells pre- and post-CID administration in four patients who developed GvHD. We identified 3,203 VIS among four patients and followed their in vivo clonal dynamics up to 161 days post-CID. VIS were categorized by their proximity to host genome elements, gene associations, and cis-modulatory relationship to mapped promoters. We found that VIS are preferentially located near open chromatin and promoter regions; furthermore, there was no evidence for selection bias among VIS surviving the CID treatment. The majority of iC9-T cells with high normalized VIS copy number at the time of GvHD onset were eliminated by CID, while iC9-T cells detectable post-CID generally have low normalized VIS copy number. We propose that suboptimal iC9 transgene expression is responsible for the incomplete elimination of iC9-T cells and illustrate here by simple model how cis-modulatory influences of local genome context and T-cell receptor activation status at time of CID treatment contribute to stochastic sparing of iC9-T cells.
Curcumin Micelles Remodel Tumor Microenvironment and Enhance Vaccine Activity in an Advanced Melanoma Model
Creators: name: Xu, Zhenghong
name: Zhao, Yi
name: Lu, Yao
name: Miao, Lei
name: Huang, Leaf
name: Shen, Youqing
name: Wang, Yuhua
name: Xiang, Guangya
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Previously, we have reported a lipid-based Trp2 peptide vaccine for immunotherapy against melanoma. The suppressive immune microenvironment in the tumor is a major hurdle for an effective vaccine therapy. We hypothesized that curcumin (CUR) would remodel the tumor microenvironment to improve the vaccine activity. Curcumin–polyethylene glycol conjugate (CUR–PEG), an amphiphilic CUR-based micelle, was delivered intravenously (i.v.) to the tumor. Indeed, in the B16F10 tumor–bearing mice, the combination of CUR–PEG and vaccine treatment resulted in a synergistic antitumor effect (P < 0.001) compared to individual treatments. In the immune organs, the combination therapy significantly boosted in vivo cytotoxic T-lymphocyte response (41.0 ± 5.0% specific killing) and interferon-γ (IFN-γ) production (sevenfold increase). In the tumor microenvironment, the combination therapy led to significantly downregulated levels of immunosuppressive factors, such as decreased numbers of myeloid-derived suppressor cells and regulatory T cells (Treg) cells and declined levels of interleukin-6 and chemokine ligand 2—in correlation with increased levels of proinflammatory cytokines, including tumor necrosis factor-α and IFN-γ as well as an elevation in the CD8+ T-cell population. The results indicated a distinct M2 to M1 phenotype switch in the treated tumors. Combining CUR–PEG and vaccine also dramatically downregulated the signal transducer and activator of transcription 3 pathway (76% reduction). Thus, we conclude that CUR–PEG is an effective agent to improve immunotherapy for advanced melanoma.
ผลของการเสริมสารสกัดจากเศษเหลือเห็ดแครง (Schizophyllum commune) ในอาหารต่อการเจริญเติบโต องค์ประกอบเลือด การตอบสนองภูมิคุ้มกัน และการป้องกันภาวะเครียดออกซิเดชั่นของปลากะพงขาว (Lates calcarifer)
Creators: name: มณี ศรีชะนันท์
Publisher: name: คณะเทคโนโลยีการเกษตร มหาวิทยาลัยราชภัฏมหาสารคาม
Year: 2022
Subjects: สารสกัดเศษเหลือเห็ดแครง
ปลากะพงขาว
สารกระตุ้นภูมิคุ้มกัน
การป้องกันภาวะเครียดออกซิเดชัน

description: วารสารเกษตรพระวรุณ, 19, 2, 17-25
Asplenium hallii Hook., Sp. Fil.
Creators: name: Kessler, Michael
name: Smith, Alan R.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Polypodiales
Aspleniaceae
Asplenium
Asplenium hallii

description: Asplenium hallii Hook., Sp. Fil. 3: 202. 1860.
 Range:— Amazonian lowlands from Colombia and Brazil to Bolivia (LP).
 Ecology:— Rare; epiphytic on tree trunks and large branches in humid forests; 1400 m in Bolivia, mainly below 400 m elsewhere.
description: Published as part of Kessler, Michael & Smith, Alan R., 2018, Prodromus of a fern flora for Bolivia. XXIX. Aspleniaceae, pp. 259-280 in Phytotaxa 344 (3) on pages 259-280, DOI: 10.11646/phytotaxa.344.3.6, http://zenodo.org/record/13720625
Asplenium hastatum Kunze, Linnaea
Creators: name: Kessler, Michael
name: Smith, Alan R.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Polypodiales
Aspleniaceae
Asplenium
Asplenium hastatum

description: Asplenium hastatum Klotzsch ex Kunze, Linnaea 23: 235, 305. 1850.
 Range:— Locally in Andes from Venezuela to Bolivia (CO).
 Ecology:— Rare; epiphytic in humid montane forests; 2100–2250 m. In Ecuador, also terrestrial in stunted ridge forest (Kessler & Lehnert 2009).
description: Published as part of Kessler, Michael & Smith, Alan R., 2018, Prodromus of a fern flora for Bolivia. XXIX. Aspleniaceae, pp. 259-280 in Phytotaxa 344 (3) on pages 259-280, DOI: 10.11646/phytotaxa.344.3.6, http://zenodo.org/record/13720625