cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Accompagnement doctoral à l'écriture et à l'évaluation scientifiques : objectivation du dispositif expérimenté autour des articles du numéro 3 de La Revue LEeE
Creators: name: Mottier Lopez, Lucie
name: Girardet, Céline
Publisher: name: La Revue LEeE
Year: 2021
Subjects: accompagnement doctoral
écriture scientifique
évaluation scientifique
évaluation entre pairs
évaluation pour apprendre durablement

description: Les textes des doctorant∙es et des chercheur∙ses présentés dans ce numéro 3 de La Revue LEeE ont fait l’objet d’un dispositif d’accompagnement à l’écriture et à l’évaluation scientifique. Ce dispositif a pour caractéristique, notamment, de s’appuyer sur des démarches plurielles d’évaluations entre pairs qui visent une « évaluation continue pour apprendre durablement »), au sein de séminaires et dans le cadre de l’évaluation ouverte et collaborative proposée par La Revue LEeE. L’article commence par problématiser l’écriture et l’évaluation scientifiques dans un contexte doctoral, puis il présente le dispositif d’accompagnement qui a duré deux ans, ainsi que les activités principales réalisées. Suite à une présentation des profils des auteur∙rices et des rétroacteur∙rices novices et expert∙es qui ont contribué à ce numéro 3, l’article expose quelques témoignages de doctorant∙es en fin de démarche d’accompagnement portant sur la façon dont ellesils ont reçu les feedbacks des pairs dans une perspective d’évaluation durable, vue comme favorable au développement de leurs compétences scientifiques, d’écriture et d’évaluation. Il se termine sur quelques constats du point de vue des directeurs et directrices de thèse intéressé∙es par une démarche de ce type.
Additional file 1 of Measuring medically unjustified hospitalizations in Switzerland
Creators: name: Eggli, Yves
name: Halfon, Patricia
name: Piaget-Rossel, Romain
name: Bischoff, Thomas
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 1. List of diagnostic categories (SQLape®).
Archives for a new world : revolutionary personal records in the Filipino-Canadian diaspora
Creators: name: Carlin, Isabel
Publisher: name: University of British Columbia
Year: 2022

description: The aim of this thesis is to investigate the relationship between personal records and politics in members of the Filipino diaspora living in Canada. The author conducted semi-structured interviews with their mother and three fellow activists, and used qualitative coding and personal writing as methods of analysis. The thesis applies archival theories of haunting, imagined records, corollary records, personal records, community archives, and other social justice-oriented archival theories through the lens of historical materialism to conclude that: (1) records, as items and aggregations, are embodied records of class struggle; (2) custody over and access to records is a form of political power; and (3) records are created in and by historical contexts of contradiction.
Therapie bei mir oder bei dir? Eine fachliche Auseinandersetzung mit den beiden Settings "aufsuchend" und "Pull-out" im logopädischen Frühbereich
Creators: name: Biastoch, Nina
name: Schwarz, Martina
Publisher: name: Zenodo
Year: 2016
Subjects: Logopädie
Bachelorarbeit

description: Die Frage nach dem Wo einer logopädischen Intervention im Frühbereich stellt sich in der Deutschschweiz kaum. Doch neben dem klassischen Pull-out gibt es auch das aufsuchende Setting, wo die Therapie in der Familie stattfindet. Die Stiftung Netz bietet beide Therapiesettings an. Sie zeigte Interesse an einer Auseinandersetzung mit ihrer Arbeitsweise. Die Arbeit beantwortet die an ICF orientierte Frage, welche Einschränkungen der Körperfunktionen, Kontextfaktoren oder externen Gegebenheiten aus Sicht von Fachpersonen für oder gegen das aufsuchende resp. das Pull-out-Setting bei logopädischen Interventionen im Frühbereich sprechen. Zur Bearbeitung der Frage wurde ein mehrstufiges Vorgehen gewählt: Literaturstudium, Internetrecherche, Befragung und Gruppendiskussion mit fünf Fachpersonen. Ein Zusammenspiel aus fachlichen und organisatorischen Gründen bildet die Grundlage für die Setting-Wahl.
Additional file 2 of Measuring medically unjustified hospitalizations in Switzerland
Creators: name: Eggli, Yves
name: Halfon, Patricia
name: Piaget-Rossel, Romain
name: Bischoff, Thomas
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 2. Most frequent diagnoses categories (all Swiss hospitals, 2016).
Logopädie Therapie mit Playmobil Teilevaluation dreidimensional inszenierter Spielsequenzen für Kinder von 4-6 Jahren mit spezifischen Spracherwerbsstörungen - Förderschwerpunkt Syntax
Creators: name: Augustin, Judit
Publisher: name: Zenodo
Year: 2016
Subjects: Logopädie
Therapie
Sprachentwicklungsstörung
Kind
Bachelorarbeit

description: Es hat sich gezeigt, dass im Bereich der Therapie grammatischer Störungen beim Evozieren der Zielstruktur Handlungsbedarf betreffend dreidimensionales Material für Kindergartenkinder besteht. Aus diesem Grund sind im Rahmen dieser Arbeit dreidimensional inszenierte Spielsequenzen für Kinder von vier bis sechs Jahren mit einer SSES - Förderschwerpunkt Syntax- entstanden und ein Teil davon evaluiert worden. Fünf Logopädinnen haben das Material getestet und wurden danach befragt. Durch eine qualitative Inhaltsanalyse sind die Befragungen ausgewertet worden. Die Ergebnisse zeigen, die Wichtigkeit ansprechendes und kindgerechtes Material zu wählen und die inszenierten Spielsequenzen so zu gestalten, dass sie sich so nahe wie möglich an der alltäglichen und individuellen Kommunikation der Kinder halten, denn nur so kann gewährleistet werden, dass gezielte Satzstrukturen evoziert werden.
Additional file 1 of Limitations of eDNA analysis for Carcinus maenas abundance estimations
Creators: name: Danziger, Ariella M.
name: Olson, Zachary H.
name: Frederich, Markus
Publisher: name: figshare
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Additional file 1: Figure S1. Photo of the filtration setup. Four filter funnels are housed in a light proof plywood box that allows for UV sterilization prior to filtration. 2 water traps collect the water and protect the vacuum pump.
SOP: Adding 3D Reference Objects to the Human Reference Atlas
Creators: name: Quardokus, Ellen M.
name: Schlehlein, Heidi
name: Bueckle, Andreas
Publisher: name: Zenodo
Year: 2023
Subjects: SOP
HuBMAP

description: The procedures outlined in this document describe how 3D reference organ objects are integrated into the Human Reference Atlas (HRA). This includes making the published models (available in the ccf-releases Github repository for each HRA release) accessible via the Human Reference Atlas (HRA) portal at https://humanatlas.io. This SOP is written for users involved in HRA publication and users that would like to download the 3D Reference Objects for use in the HRA or other user interfaces.
Cicadalna Boulard 2006, n. gen.
Creators: name: Boulard, Michel
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Cicadidae
Cicadalna

description: Espèce type: Cicadalna takensis n. sp. ci-dessous décrite. Diagnose générique. - Tête en cône à base large, plus large que le mésonotum. Marges pronotales rabattues sur le côtés et dépourvues de denticules. Opercules fermant bien les chambres acoustiques latéro-ventrales. Cymbacalyptes courts et arrondis, laissant les cymbales largement à découvert. Pygophore dépourvu de lobes latéraux. Phallicophore pourvu de lobes latéro-postérieurs développés en forts crochets copulatoires. Phallus du type cicadatréen, avec phallotrème couronné d'épines phalliques inégales. Chez les vraies Cigales (famille des Cicadidae Latreille, 1 802: KÜNCKEL D'HERCULAIS, 1885, Boulard, 1988, Moulds, 2005), ce nouveau genre prend place dans la sous-famille des Cicadinae et la tribu des Cicadini, aux côtés des genres Cicada Linné, 1758, et Cicadatra Amyot, 1 847, dont il se distingue par la forme de la tête, celle, en demi-lune, des opercules, par le port, très latéral, des cymbacalyptes et par la conformation générale du bloc génital.
description: Published as part of Boulard, Michel, 2006, Cicadalna takensis, nouvelle espèce d'un genre nouveau découverte en Thaïlande du Nord (Rhynchota, Cicadidae), pp. 529-534 in Bulletin de la Société entomologique de France 111 (4) on page 529, DOI: 10.3406/bsef.2006.16370, http://zenodo.org/record/7928612
description: {"references": ["KUnckel d'Herculais J., 1885. - Les Cicadides ou Cigales chanteuses, Cicadidae ou Stridulantia, dans: A. - E. Brehm, Merveilles de la Nature, les Insectes, les Myriopodes, les Arachnides. Paris, Bailliere, 1885: 475 - 480.", "Boulard M., 1988. - Taxonomie et Nomenclature superieures des Cicadoidea. Histoire, problemes et solutions. E. P. H. E., Biologie et Evolution des Insectes, 1, 1988: 1 - 90.", "Moulds M. S., 2005. - An appraisal of the higher classification of Cicadas (Hemiptera: Cicadoidea) with special reference to the Australian fauna. Records ofthe Australian Museum, 57: 375 - 446.", "LINNE C., 1758. - Hemiptera, dans: Systema naturae per regna tria naturae, secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis. Editio decima, reformata, 1. Stockholm, Laurentii Salri, i-iv, 1 - 824."]}
An Ecocritical Reading of Blood Meridian and Strange as This Weather Has Been
Creators: name: Zakarriya, Jihan
Publisher: name: ASJ
Year: 2019

description: This article provides a postcolonial ecocritical perspective on modern American novels by relating and examining aspects of ecological and human violence in Cormac McCarthy’s Blood Meridian: The Evening Redness in the West (1985) and Anne Pancake’s Strange as This Weather Has Been (2007). While McCarthy represents examples of ethnic and racial violence and Pancake focuses on class violence, the two novelists articulate a particular awareness of the interconnections between economic and political hierarchies and different forms of ecological and human violence in different American contexts. The two novels, then, denounce the deterministic, colonial constructions of economy, power, and knowledge in modern societies on the one hand and the validation of antagonism and violence against otherness and difference on the other. Specifically examining daily experiences, psychological-mental challenges, and changes of the fifteen-years-old female teenager, Bant, in Strange as This Weather Has Been and the male teenager, the kid, in Blood Meridian, I will show how specific individuals and groups deconstruct deterministic, colonial constructions of patriarchy and violence through their ecological awareness. My analysis exposes that colonizing and colonized countries still suffer from discrepancies and contradictions of colonial culture and modern politics and ultimately reveals the limitations of white Americans’ freedom and equality within colonial and national frameworks.
description: American studies journal; Vol. 66, No. 06, 2019. 2199-7268
description: Special Issue: Miscellaneous Articles
Kochen - als Spiel mit einem Kind
Creators: name: Schwery, Joséphine
Publisher: name: Zenodo
Year: 2016
Subjects: Psychomotorik
Psychomotoriktherapie
Kochen
Kind
Bachelorarbeit

description: Im Rahmen der vorliegenden Arbeit habe ich im Sinne eines Entwicklungsprojektes ein Kochbuch zur feinmotorischen Förderung entwickelt: „Kochen-als Spiel mit einem Kind“. Der Inhalt des Kochbuches orientiert sich an psychomotorischem Gedankengut. Jedes Rezept enthält Schritte zur Erschwerung oder Erleichterung der Durchführung. Diese basieren auf handmotorischen Entwicklungstheorien. Überlegungen zum kindlichen Lernen und Fördern erhielten eine richtungsweisende Rolle.
Additional file 3 of NRG1 fusions in breast cancer
Creators: name: Howarth, Karen D.
name: Mirza, Tashfina
name: Cooke, Susanna L.
name: Chin, Suet-Feung
name: Pole, Jessica C.
name: Turro, Ernest
name: Eldridge, Matthew D.
name: Garcia, Raquel Manzano
name: Rueda, Oscar M.
name: Boursnell, Chris
name: Abraham, Jean E.
name: Caldas, Carlos
name: Edwards, Paul A. W.
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3: Supplementary Textfile 1. Representative sequences of NRG1 fusion transcripts.
Additional file 1 of Dual SGLT-1 and SGLT-2 inhibition improves left atrial dysfunction in HFpEF
Creators: name: Bode, David
name: Semmler, Lukas
name: Wakula, Paulina
name: Hegemann, Niklas
name: Primessnig, Uwe
name: Beindorff, Nicola
name: Powell, David
name: Dahmen, Raphael
name: Ruetten, Hartmut
name: Oeing, Christian
name: Alogna, Alessio
name: Messroghli, Daniel
name: Burkert M. Pieske
name: Heinzel, Frank R.
name: Hohendanner, Felix
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 1: Figure S1. (A) Longitudinal and (B) transversal LV fractional shortening as observed in echocardiography (parasternal long axis view). (C) Correlation of longitudinal and (D) transversal LV fractional shortening with LA volume. (E) Exemplary electrocardiogram to monitor atrial fibrillation (excerpt of 30 min continuous recording). (F) Total occurrence of atrial fibrillation during screened time intervals. (G) Serum concentration of creatinine and (H) urea. Statistical analysis: Two-way ANOVA followed by post-hoc Bonferroni (G, H). n = animals. 10.016, 2
SOP: Using 3D Reference Objects
Creators: name: Bueckle, Andreas
name: Browne, Kristen
name: Herr II, Bruce W.
name: Borner, Katy
Publisher: name: Zenodo
Year: 2021
Subjects: SOP
HuBMAP

description: The procedures outlined in this document describe how approved 3D reference organ objects are integrated into the CCF Portal 3D Reference Object Library on the CCF Portal, the Registration User Interface (RUI), and the Exploration User Interface (EUI).
Additional file 6 of Differential CpG DNA methylation of peripheral B cells, CD4+ T cells, and salivary gland tissues in IgG4-related disease
Creators: name: Wu, Xunyao
name: Wang, Anqi
name: Wang, Mu
name: Peng, Yu
name: Chen, Yingying
name: Li, Jieqiong
name: Liu, Zheng
name: Lu, Hui
name: Zhou, Jiaxin
name: Peng, Linyi
name: Zhao, Yan
name: Zeng, Xiaofeng
name: Fei, Yunyun
name: Zhang, Wen
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 6: Supplementary Table 6. The top 25 hypermethylated CpG sites in salivary gland tissues of IgG4-RD patients.
Campylobacter jejuni 1291 in cell morphology and pathogenesis
Creators: name: Dechka, Jennifer
Publisher: name: University of British Columbia
Year: 2022

description: Campylobacter jejuni is a widespread enteric pathogen that causes mild to severe gastroenteritis in humans. Despite the prevalence of C. jejuni, its virulence mechanisms are poorly understood. It had long been postulated that C. jejuni’s characteristic helical shape was important for pathogenesis, which our group has now shown to be the case. Peptidoglycan remodelling enzymes play a key role in maintaining cell shape. The LytM domain-containing protein 1291 was identified while searching the C. jejuni genome for peptidoglycan peptidases. As 1291 was predicted to lack proteolytic activity, it was subsequently predicted to activate the C. jejuni amidase, AmiA. Deletion of 1291 caused distinct phenotypic changes compared to wild type C. jejuni. The 1291 deletion mutant demonstrated a long chain-like cellular morphology similar to an amiA deletion strain and contributed to key pathogenesis phenotypes. In comparison to wild type, ∆1291 displayed severe motility and autoagglutination defects, as well as an increase in biofilm formation. Both 1291 and the E. coli LytM domain-containing amidase activator EnvC showed cross-species complementation. Specifically, 1291 was able to complement the severe chaining phenotype of an E. coli amidase activator deletion strain, and EnvC was able to complement the chain-like phenotype of ∆1291. This work provides evidence that 1291 acts as a pathogenesis factor in C. jejuni and is involved in cellular morphological changes, likely through the activation of C. jejuni’s sole amidase, AmiA.
SOP: Using 3D Reference Objects
Creators: name: Quardokus, Ellen M.
name: Bueckle, Andreas
Publisher: name: Zenodo
Year: 2022
Subjects: SOP
HuBMAP

description: The procedures outlined in this document describe how 3D reference organ objects are integrated into the CCF Portal 3D Reference Object Library on the CCF Portal, the Registration User Interface (RUI), and the Exploration User Interface (EUI).
Bindung und Familienzeichnung Eine Arbeit über den Zusammenhang von gezeigten Bindungserfahrungen im Geschichtenergänzungsverfahren und den dargestellten Beziehungsstrukturen auf Familienzeichnungen
Creators: name: Kappeler, Céline
Publisher: name: Zenodo
Year: 2016
Subjects: Psychomotorik
Psychomotoriktherapie
Zeichnung
Familie
Bachelorarbeit

description: Die Bindung, das emotionale Band zwischen Kindern und ihren Fürsorgepersonen, nimmt eine überlebenswichtige Funktion im Leben des Kindes ein. Auch für den Therapieerfolg ist die Bedeutung der therapeutischen Beziehung empirisch gut belegt. Oft gestaltet sich der Beziehungsaufbau jedoch als schwieriger, Bindungsauffälligkeiten können vorliegen. Diese zu diagnostizieren braucht meist viel Zeit und die Kinder sind häufig Stress ausgesetzt. Gibt es auch eine einfachere Methode? Ausgehend von diesen Überlegungen beleuchtet diese Arbeit den Zusammenhang zwischen gezeigten Bindungserfahrungen im Geschichtenergänzungsverfahren und der familiären Beziehungsstruktur, wie sie im Verfahren Familie in Tieren zeichnerisch dargestellt wird. Es wird aufgezeigt, dass ein Zusammenhang entsteht und eine grobe Gliederung in sicher und unsicher gebundene Kinder anhand der Zeichnungen vorgenommen werden kann.
title: [Rezension zu:] Mario Ascheri, The Laws of Late Medieval Italy (1000–1500). Foundations for a European Legal System, Leiden, Boston (Brill) 2013, XVI–427 p., 3 b/w ill.,ISBN 978-90-04-21186-5, EUR 139,00.
Creators: name: Baumgärtner, Ingrid
Publisher: name: Universität Kassel
Year: 2014
Subjects: subject: 900
subject: Italien
subject: Recht
subject: Rezension

description: CC BY-NC-ND 3.0
Additional file 7 of Differential CpG DNA methylation of peripheral B cells, CD4+ T cells, and salivary gland tissues in IgG4-related disease
Creators: name: Wu, Xunyao
name: Wang, Anqi
name: Wang, Mu
name: Peng, Yu
name: Chen, Yingying
name: Li, Jieqiong
name: Liu, Zheng
name: Lu, Hui
name: Zhou, Jiaxin
name: Peng, Linyi
name: Zhao, Yan
name: Zeng, Xiaofeng
name: Fei, Yunyun
name: Zhang, Wen
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 7: Supplementary Table 7. The top 25 hypomethylated CpG sites in salivary gland tissues of IgG4-RD patients.
Additional file 1 of NRG1 fusions in breast cancer
Creators: name: Howarth, Karen D.
name: Mirza, Tashfina
name: Cooke, Susanna L.
name: Chin, Suet-Feung
name: Pole, Jessica C.
name: Turro, Ernest
name: Eldridge, Matthew D.
name: Garcia, Raquel Manzano
name: Rueda, Oscar M.
name: Boursnell, Chris
name: Abraham, Jean E.
name: Caldas, Carlos
name: Edwards, Paul A. W.
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Supplementary Figure 1. Sashimi plots of RNA sequencing of fusion in MDA-MB-175. Supplementary Figure 2. RNA expression levels in MDA-MB-175 by RNA-seq. Supplementary Figure 3. Additional gene fusions in MDA-MB-175. Supplementary Figure 4. Examples of verification by PCR of fusions in MDA-MB-175. Supplementary Figure 5. Genomic localisation of fusion in breast cancer cell line MDA-MB-175, by FISH. Supplementary Figure 6. Genomic copy number changes in MDA-MB-175. Supplementary Figure 7. Expression of NRG1 fusion proteins by transfection in HEK 293T cells. Supplementary Figure 8. Simplest reconstruction of NRG1 rearrangements that create the ZNF704-NRG1 fusion.
A transgenic macrophage-based platform to assess the efficacy and specificity of HuR modulators in inflammation
Creators: name: Dushku, Esmeralda
name: Gavriilidis, Maxim
name: Mavrommatis-Parasidis, Panagiotis
name: Kontoyiannis, Dimitris L
Publisher: name: Journal of Biological Research - Thessaloniki
Year: 2023
Subjects: post-transcriptional regulation; RNA-binding proteins; animal models; AU-rich elements; chemotherapeutics; cancer; preclinical evaluation

description: RNA-binding proteins (RBPs) are essential controllers of RNA metabolism, and their deregulation can cause various pathologies. Human Antigen R (HuR) is an RBP engaged in the nuclear and cytoplasmic regulation of critical RNAs involved in cellular homeostasis. Conversely, its deregulation leads to tissue degeneration, cancer and immunopathology, fueling efforts for its exploitation as a target for relevant therapeutics. An expanding list of natural and synthetic compounds has been generated that disrupt HuR’s affinity for RNA, block its subcellular movements or debilitate its expression. The use of such HuR-inhibitors shows promise in the management of several cancers. However, the divergent functions of HuR on inflammatory degenerations – as revealed in animal models of HuR’s obligatory and tissue-specific ablation – raise skepticism on the use of HuRinhibitors against inflammatory reactions – including those associated with tumors. In many cases, this is due to the poor integration of appropriate cell-based assays to provide insights into applicability for controlling inflammatory reactions. Here, we present a transgenic macrophage-based platform for the functional assessment of HuR inhibitors that considers the context of HuR activities in inflammation that fail when HuR is lost. We employ this platform to assess the specificity and efficacy of three publicly available and prototypical HuR disruptors and two anti-inflammatory compounds known to alter HuR’s subcellular localization. We demonstrate that only one HuR-disruptor possesses HuR-dependent and selective anti-inflammatory activities, which do not extend the pathologic side effects incurred by the complete obliteration of HuR in immune cells. Our data provide a proof-of-principle case on appropriately assessing the modulators of HuR, highlighting the need to exploit context-specific cell-based assays for the preclinical evaluation of RBP inhibitors.
description: Journal of Biological Research - Thessaloniki, Vol 30 (2023)
Inter-organ signalling by hepatocyte-derived microRNA-122
Creators: name: Matthews, Olivia Fay
Publisher: name: The University of Edinburgh
Year: 2021
Subjects: miRNA
paracetamol
miRNA-122
acute liver injury
CYP450
signalling

description: MicroRNAs (miRNAs) are small non-protein coding RNA species involved in the regulation of gene expression. Bound to either protein or encapsulated in extracellular vesicles (EVs), miRNA are released from the cell and found within biological fluids. Following release, miRNAs have shown to play a role in cellular communication in vitro and to a lesser extent in vivo. The studies described in this thesis aimed to investigate the organ uptake of the hepatocyte enriched miRNA, miR-122, in vivo during in the absence and presence of paracetamol-related drug induced liver injury (DILI). As it is known that kidney tubules can internalise EVs containing miRNA, it was hypothesised that miR-122 released from the liver during paracetamol-related DILI, enters the kidney and has a protective role against subsequent injury. The production of miRNA is reliant on the activity of the cytoplasmic enzyme Dicer. To induced Dicer1 knockdown, Dicer1 flox/flox mice were treated with a hepatotropic Cre-AAV8 or its negative control Null-AAV8. In this model, investigation of Dicer expression via western blotting and RT-qPCR indicated a significant loss of Dicer in the liver one week following Cre-AAV8 treatment. Consequently, a time dependent loss of total hepatic miRNA was observed using RT-qPCR and in situ hybridisation. Cre-recombinase delivery was confirmed to be liver-specific with stable Dicer and organ-enriched miRNA expression in the spleen, kidney, heart, lung and brain. In the absence of DILI, It was found that the loss of total miRNA in the liver resulted in a significant reduction of miR-122 expression in the spleen and kidney. During paracetamol-induced liver injury, the well described increase of miR-122 in the circulation was not observed in the Cre-AAV8 treated mice. Subsequently, the increase of miR-122 expression in the spleen, kidney and heart was significantly diminished with the loss of hepatic miRNA production. Depletion of miR-122 resulted in an increase of CYP2E1 expression and activity in the liver and kidney following 300mg/kg paracetamol. Therefore, these findings show that under normal physiological conditions, expression of miR-122 in the spleen and kidney is reliant on miRNA transfer from the liver. During paracetamol induced hepatotoxicity, the mechanism of miR-122 signalling is upregulated and extends to the heart. Lastly, the observed upregulation of CYP2E1 following a loss of miR-122 in the kidneys indicates hepatic miRNA plays a role in regulating drug metabolism in the kidney.
Additional file 1 of A flavonoid rich standardized extract of Glycyrrhiza glabra protects intestinal epithelial barrier function and regulates the tight-junction proteins expression
Creators: name: Murugan, Sasi Kumar
name: Bethapudi, Bharathi
name: Raghunandhakumar, Subramanian
name: Purusothaman, Divya
name: Nithyanantham, Muruganantham
name: Mundkinajeddu, Deepak
name: Talkad, Muralidhar Srinivasaih
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Additional file 1: Supplementary Figure S1. The unprocessed immune blot data of individual tight junction proteins from experimental rats colon tissue sample.
The challenge of assessing effective science communication training
Creators: name: Bedolla López, Diana
Publisher: name: University of British Columbia
Year: 2022

description: During the past few decades, an increasing number of science communication training events have been on offer. The focus of these events is mainly on developing technical, journalistic-type skills in ‘getting the message across.’ This training often relies on the deficit model, which assumes that the public is undereducated. This assumption is problematic because it ignores that the different targeted audiences have different types and levels of knowledge and ways of interpreting information that depend on values, beliefs, and concerns. A review of the literature suggests an assessment of current practices could motivate reflection among science communication trainers on the utility of the deficit model. To date, no tool is available that assesses the effectiveness of science communication training. This study aims to address this gap by developing a framework and a tool to assess the effectiveness of science communication training. This study employs community-based participatory action research in collaboration with the Society of Environmental Toxicology and Chemistry (SETAC). Data were collected using a review of training in science communication, surveys, informal conversations, and participant observations. The framework developed in this thesis conceptualizes science communication training assessment using a modified Kirkpatrick model, the Theory of Planned Behavior, and an authentic assessment approach. The survey offers a functional tool to assess previous knowledge in science communication, expectation, and interests before the training and a change in knowledge, skills, and planned behavior after the training. In addition, this thesis provides support for the hypothesis that an assessment framework can motivate science communication trainers to reflect on the utility of the deficit model and help them design, select, and use strategies that are appropriate for their initiatives. Researching the relationship between the current state of science communication training relying on the deficit model makes it evident that a revised approach to training is needed. This study adds to the understanding of science communication assessment as the first step for improvement.
Additional file 1 of Early-stage studies to larger-scale trials: investigators’ perspectives on scaling-up childhood obesity interventions
Creators: name: von Klinggraeff, L.
name: Dugger, R.
name: Okely, A. D.
name: Lubans, D.
name: Jago, R.
name: Burkart, S.
name: Weaver, R. G.
name: Armstrong, B.
name: Pfledderer, C. D.
name: Beets, M. W.
Publisher: name: figshare
Year: 2022
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Additional file 1. Semi-Structured Interview Guide.
Additional file 2 of Early-stage studies to larger-scale trials: investigators’ perspectives on scaling-up childhood obesity interventions
Creators: name: von Klinggraeff, L.
name: Dugger, R.
name: Okely, A. D.
name: Lubans, D.
name: Jago, R.
name: Burkart, S.
name: Weaver, R. G.
name: Armstrong, B.
name: Pfledderer, C. D.
name: Beets, M. W.
Publisher: name: figshare
Year: 2022
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Additional file 2. A Priori Themes and Emergent Themes.
GESTÃO DE RISCOS E DESAFIOS: UM ESTUDO DE CASO SOBRE CONDIÇÕES DE TRABALHO E ATUAÇÃO DA CIPA
Creators: name: Araujo, Elliciane de Sousa
Publisher: name: Vistacien
Year: 2023
Subjects: CIPA
Condições de Trabalho
Gestão
Legislação Trabalhista

description: Este estudo de caso destaca as condições precárias de trabalho enfrentadas por uma grávida em uma empresa terceirizada de estacionamento, levando à ativação da CIPA. A vice-presidente da CIPA, ao perceber a gravidade, ameaçou acionar a justiça do trabalho, resultando na transferência da funcionária. A resistência da administração em relação ao cipeiro e a mudança na gestão evidenciam desafios na cultura organizacional. A persistência do gestor do SESMT na CIPA após o prazo de candidatura reflete a necessidade de fortalecer as estruturas de governança em segurança no trabalho. Destaca-se a importância da legislação trabalhista na proteção dos membros da CIPA. A atuação proativa desses representantes é crucial para garantir ambientes laborais seguros.
Sui termini del procedimento sanzionatorio dell’ARERA: perentori o ordinatori, questo è il dilemma (nota a Cons. Stato, sez. VI, 17 marzo 2021, n. 2309)
Creators: name: Delle Cave, Gianluigi
Publisher: name: CERIDAP
Year: 2022

CERIDAP, 1 (2022)
Additional file 3 of Differential CpG DNA methylation of peripheral B cells, CD4+ T cells, and salivary gland tissues in IgG4-related disease
Creators: name: Wu, Xunyao
name: Wang, Anqi
name: Wang, Mu
name: Peng, Yu
name: Chen, Yingying
name: Li, Jieqiong
name: Liu, Zheng
name: Lu, Hui
name: Zhou, Jiaxin
name: Peng, Linyi
name: Zhao, Yan
name: Zeng, Xiaofeng
name: Fei, Yunyun
name: Zhang, Wen
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 3: Supplementary Table 3. The top 10 hypomethylated CpG sites in B cells of IgG4-RD patients.
Additional file 1 of Surface charge modulation of rifampicin-loaded PLA nanoparticles to improve antibiotic delivery in Staphylococcus aureus biofilms
Creators: name: Costa, David Da
name: Exbrayat-Héritier, Chloé
name: Rambaud, Basile
name: Megy, Simon
name: Terreux, Raphaël
name: Verrier, Bernard
name: Primard, Charlotte
Publisher: name: figshare
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Cytotoxicity of plain, RIF-loaded and PLL-coated NPs. Cell viability of murine Raw 264.7 macrophages (a) and NIH/3T3 fibroblasts (b), evaluated by PrestoBlue assay. Percentages are reported to the untreated condition. Values are means ± SD of three replicates for one representative experiment out of two independent ones.
Additional file 4 of Differential CpG DNA methylation of peripheral B cells, CD4+ T cells, and salivary gland tissues in IgG4-related disease
Creators: name: Wu, Xunyao
name: Wang, Anqi
name: Wang, Mu
name: Peng, Yu
name: Chen, Yingying
name: Li, Jieqiong
name: Liu, Zheng
name: Lu, Hui
name: Zhou, Jiaxin
name: Peng, Linyi
name: Zhao, Yan
name: Zeng, Xiaofeng
name: Fei, Yunyun
name: Zhang, Wen
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 4: Supplementary Table 4. The top 10 hypermethylated CpG sites in CD4+ T cells of IgG4-RD patients.
Role of Gpr56 in mammalian haematopoiesis
Creators: name: Maglitto, Antonio
Publisher: name: The University of Edinburgh
Year: 2021
Subjects: hematopoietic stem cells
Gpr56

description: Haematopoietic stem cells (HSCs) can differentiate into all blood cell types, making HSC transplantation a promising treatment for many blood-related disorders. Allogenic heathy HSCs can be transplanted into patients, although this approach is limited by availability and compatibility of the donor. Moreover, there are no protocols available to generate transplantable HSCs from pluripotent stem cells (PSC), or expand HSCs ex vivo, as the molecules involved in HSC ontogeny remain poorly understood. Embryonically, HSCs derive from a subset of aortic endothelial cells that undergo endothelial-to-hematopoietic transition to become HSCs. During this dynamic process, Gpr56 is the most upregulated receptor in emerging HSCs. The Gpr56 protein is a cell-surface receptor that is likely involved in the regulation of HSC function. However, its role in mammalian haematopoiesis remains unknown. In this study, we examine the function of Gpr56 during in vivo and in vitro HSC development. To explore the effect of Gpr56 loss-of-function, we characterize the functional role of mouse embryonic stem cell (ESC) derived hematopoietic stem and progenitor cells (HSPCs) and in vivo mouse HSCs that lack Gpr56. Gpr56-deficient HSPCs have a differentiation bias towards myeloid cells and the upregulation of another GPCR, Gpr97 appeared to compensate for Gpr56 deletion. The simultaneous deletion of Gpr56 and Gpr97 severely impaired the production of HSPCs, suggesting that both GPCRs are required in vitro for HSPC generation. Conversely, Gpr56 overexpression during human in vitro PSC differentiation resulted in an important HSPC expansion. In summary, these data demonstrate that the lack of Gpr56 alters the HSPC differentiation output, while its overexpression enhances human in vitro HSPCs generation. This work represents the most comprehensive and current study of Gpr56 in mammalian haematopoiesis and these findings will improve novel strategies to generate de novo HSC and/or promote their ex vivo expansion.
Additional file 1 of Assessment of the quality of the vital registration system for under-5 mortality in Yucatan, Mexico
Creators: name: Hernandez, Bernardo
name: Rodriguez Angulo, Elsa
name: Johnson, Louisa M.
name: Palmisano, Erin B.
name: Ojeda, Ricardo
name: Ojeda, Rafael
name: Gómez Carro, Salvador
name: Chen, Alan
name: Camarda, Joseph
name: Johanns, Casey
name: Flaxman, Abraham
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Additional file 1. GC13 Adult Gold Standard Diagnoses.
Additional file 1 of Two-year prevalence rates of mental health and substance use disorder diagnoses among repeat arrestees
Creators: name: Magee, Lauren A.
name: J. Dennis Fortenberry
name: Rosenman, Marc
name: Aalsma, Matthew C.
name: Gharbi, Sami
name: Wiehe, Sarah E.
Publisher: name: figshare
Year: 2021
Subjects: subject: Cell Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: Additional file 1.
Coarse-grained theories for fluids
Creators: name: Luo, Siwei
Publisher: name: University of British Columbia
Year: 2022

description: Coarse-grained (CG) models reduce the number of degrees of freedom in a system, allowing the dynamics of large systems to be studied for longer times. Many biological simulations today are performed using CG potentials. However, the use of Newtonian equations of motion (EOM) for mesoscopic variables only yields correct equilibrium properties but with the wrong dynamics. Conventional CG mapping schemes such as the center-of-mass mapping are also not suitable for coarse-graining nonbonded fluid systems. The conservative terms in the CG EOM derived using Mori-Zwanzig theory are studied. The fluid systems are divided into cubic subcells with equal volumes. Atomistic particles associated with a subcell are mapped to a set of position-dependent CG variables using either a Heaviside function or a fuzzy function. A diffusion blob model is developed to qualitatively understand the correlation between two subcells. The distribution of CG mass is found to change from symmetric and discrete to skewed and continuous. The form of the CG potential can be approximated as a multivariate Gaussian. Distribution function theory is used to derive the parameters of the CG potential analytically. The behaviour of the potential parameters as a function of different geometric relationships, the size of the subcell or the fuzziness of the subcell boundary, is discussed. A density-based expansion method is developed to quantitatively understand the behaviour of the one-dimensional distribution of CG variables. The origin of the skewed mass distribution comes from the asymmetry in the variance of CG mass distribution conditioned on a fixed number of atoms. The projected fluxes are studied with distribution function theory and Gaussian process regression. This work provides a basis for correctly simulating complex fluid systems at a mesoscopic scale without any ad-hoc assumptions. The Gaussian-like CG potential is general for single-component, atomic fluids. Parameters of a CG potential are, for the first time, computed from analytical theories. Understanding the source of the skewed mass gives a complete solution to finding the correct fluctuation for densities. This solves a long-standing problem in fluctuating hydrodynamics. The density-based expansion formula gives a complete solution to the back-mapping problem in performing multiscale simulations.
title: Governance der Klimaanpassung: Akteursstrukturen im Traben-Trarbacher Weintourismus
Creators: name: Wiegleb, Viviana
Publisher: name: Universität Trier
Year: 2023
Subjects: subject: Governance
valueUri: http://d-nb.info/gnd/4639012-1
subject: Klimaänderung
valueUri: http://d-nb.info/gnd/4164199-1
subject: Tourismus
valueUri: http://d-nb.info/gnd/4018406-7
subject: Traben-Trarbach Region
valueUri: http://d-nb.info/gnd/7593251-9
subject: Weinbau
valueUri: http://d-nb.info/gnd/4065136-8

description: Anpassung an den Klimawandel stellt eine komplexe gesellschaftliche Herausforderung dar und hat Bezug zu steuerungstheoretischen Fragen um Governance. Klimaanpassung zeichnet sich aus durch die Zusammenarbeit staatlicher und nicht-staatlicher Akteure, netzwerkartige Strukturen, flexible Steuerungsmechanismen sowie formelle und informelle Koordinationsstrukturen. Für die erfolgreiche Gestaltung von Klimaanpassungspolitik müssen vielfältige Akteurs- und Interessenskonstellationen berücksichtigt werden. Ziel der vorliegenden Studie ist es, das Traben-Trarbacher Akteurs- und Stakeholdernetzwerk aus Perspektive der Klimaanpassung zu analysieren. Ein besonderer Fokus liegt hierbei auf den regionalwirtschaftlich bedeutenden Sektoren Weinbau und Tourismus, die integriert und im Kontext von kommunalen, regionalen und überregionalen Strukturen betrachtet werden. Im Rahmen der Analyse wurden das Beziehungsgeflecht, die Reichweite und Diversität des Netzwerks sowie die Zusammensetzung der Akteurslandschaft dargestellt. Darüber hinaus konnten wichtige Schlüsselakteure, potenzielle Multiplikatoren, Interdependenzen zwischen Weinbau und Tourismus sowie Informations- und Wissensquellen identifiziert werden. Die Ergebnisse der Stakeholderanalyse geben wichtige Hinweise darauf, welche Akteure in Steuerungsprozesse von Klimaanpassung einbezogen und welche lokalen Gegebenheiten und Beziehungen hierbei berücksichtig werden müssen. Besonders die Zusammensetzung der Akteure hat entscheidenden Einfluss auf den Verlauf und Erfolg der Steuerung von Klimaanpassung. Die vorliegende Stakeholderanalyse schafft also eine wichtige Grundlage zur Etablierung eines Governance-Netzwerks für die Erarbeitung und Erprobung von Klimawandelanpassungsmaßnahmen in Traben-Trarbach und der Moselregion. Damit dient die Analyse der langfristigen Verankerung von Klimaanpassung in der Region und kann auch als Anregung für weitere Kommunen genutzt werden, die vor ähnlichen Herausforderungen stehen wie Traben-Trarbach.
title: Induced lupus : paradigm and particularities
title: Le lupus induit : paradigme et particularités
Creators: name: Chekkouri, Fatima Zahra
Publisher: name: Revue Marocaine de Rhumatologie (RMR)
Year: 2021
Subjects: Lupus induit; Modulateur biologique; Facteurs génétiques.

description: Induced lupus (IL) is defined as a lupic syndrome secondary to continuous exposure to a drug, which is responsible for the induction of auto-immunity phenomena. Its mechanism remains unclear, involving several factors, in particular genetic and environmental factors. The clinical, biological and histological aspects are similar to those of systemic lupus erythematosus (SLE). The lower severity of symptoms, the rarity of systemic attacks and the regression of signs when the inducing drug is stopped are in favor of IL. The treatment of IL involves the interruption of the drug in question, with a favorable evolution often after the causative drug has been stopped.
description: Le lupus induit (LI) est défini comme un syndrome lupique secondaire à une exposition continue à un médicament, responsable d’induction de phénomènes d’auto immunité. Son mécanisme reste mal élucidé faisant intervenir plusieurs facteurs génétiques et environnementaux. Les aspects cliniques, biologiques et histologiques sont proches de ceux du lupus érythémateux systémique (LES). La moindre sévérité des symptômes, la rareté d’atteintes systémiques et la régression des signes à l’arrêt du médicament sont en faveur du LI. Le traitement du LI passe par la reconnaissance et l’interruption du médicament incriminé. L’évolution est souvent favorable après l’arrêt du médicament responsable.
title: Styles of Romano-British cremation and associated deposition in south-east England
Creators: name: Weekes, Jason Richard
Publisher: name: University of Kent
Year: 2005

description: This thesis develops and tests an analytical method of delineating ritual styles within the context of a particular type of ritual sequence: Roman period cremation and associated deposition. Part one deals with theoretical issues, initially discussing the inherent problem of seeking `monolithic' meanings for ritual sequences, focussing attention on the reconstruction of ritual action from the archaeological record, and developing diagnostic indices (selection and modification of objects, temporal and spatial features) along which ritual sequences might be compared, and profiles of ritual styles at regional, local, site- and burial- level produced. A method that will take account not only of homogeneity but also diversity at these levels is proposed. Current theoretical debates on cremation and associated deposition are then re-evaluated. Finally the methodology used is outlined and discussed, with particular emphasis on transparency of analytical criteria. Parts two and three report findings, developing profiles of cremation and associated cremation burials from east Kent case studies focussed on Canterbury and comparative case studies from Colchester, Essex, and east London respectively. Part four compares the profiles generated in previous chapters, delineating homogeneity and diversity in ritual styles and meaning. Cremation practices appear to have been quite uniform, governed by the need for specialist knowledge and skill; there is some evidence however that pyre side ritual could be more diverse. The data suggest an overall increase in cremation burials in the second and third centuries, and while general traditions in certain components of burials are clear, so too is considerable and increasing diversity at local, and especially burial level in terms of accessories. Each ritual sequence seems to have had the capacity to incorporate region wide references, as well as many more diverse meanings contingent on the locality and even personality of ritual participants and those whose remains were afforded such treatment.
Additional file 2 of Assessment of the quality of the vital registration system for under-5 mortality in Yucatan, Mexico
Creators: name: Hernandez, Bernardo
name: Rodriguez Angulo, Elsa
name: Johnson, Louisa M.
name: Palmisano, Erin B.
name: Ojeda, Ricardo
name: Ojeda, Rafael
name: Gómez Carro, Salvador
name: Chen, Alan
name: Camarda, Joseph
name: Johanns, Casey
name: Flaxman, Abraham
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Additional file 2. Table 1: Vital Statistics Performance Index (VSPI) scores by place of death for under-5 deaths in Yucatan, Mexico, 2015–2016.