cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Eine kognitions- und neurowissenschaftliche Erkenntnisdimension für die Mathematikdidaktik
Creators: name: Pielsticker, Felicitas
name: Witzke, Ingo
Publisher: name: Gesellschaft für Didaktik der Mathematik
Year: 2023
Subjects: subject: kognitions- und neurowissenschaftliche Erkenntnisdimension
subject: Grundlagenforschung
subject: bildgebende Verfahren
subject: Hochschule
subject: interdisziplinär
subject: Problemlösen
subject: 510

description: Anspruch der Bildungsforschung im Allgemeinen – und der Mathematikdidaktik im Besonderen – ist es Lernprozesse von Schüler*innen möglichst präzise und ganzheitlich zu beschreiben. Mit Blick auf dieses Ziel ist es sehr verwunderlich, dass neurowissenschaftliche Erkenntnisse bzw. Erkenntnisse auf Grundlage (medizinischer) Bildgebungs- und Messverfahren – zumindest mit Blick auf die deutsche mathematikdidaktische Community – nicht mehr Berücksichtigung in der bildungswissenschaftlichen Forschung finden. Jedoch lässt sich festhalten, dass durch die rasante technische Entwicklung mittlerweile gut verfügbarer digitaler Technologien wie Eye-Tracking, Bewegungs- Tracking, VR-Analyse, fMRT, EEG etc. die Möglichkeit besteht, systematisch die mathematikdidaktische Grundlagenforschung um neue Perspektiven zu bereichern (Pielsticker et al., 2022; Pielsticker, 2022).
$K^+Λ$ electroproduction above the resonance region
Creators: name: Vrancx, Tom
name: Ryckebusch, Jan
name: Nys, Jannes
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Background: In $π^+n$ and $π^-p$ electroproduction, conventional models cannot satisfactory explain the data above the resonance region, in particular the transverse cross section. Although no high-energy L-T-separated cross-section data is available to date, a similar scenario can be inferred for $K^+Λ$ electroproduction. Purpose: Develop a phenomenological model for the $p(γ^*,K^+)Λ$ reaction at forward angles and high-energies. Propose a universal framework for interpreting charged-kaon and charged-pion electroproduction above the resonance region. Method: Guided by the recent model for charged-pion electroproduction, developed by the authors, a framework for $K^+Λ$ electroproduction at high energies and forward angles is constructed. To this end, a Reggeized background model for $K^+Λ$ photoproduction is first developed. This model is used as a starting base to set up an electroproduction framework. Results: The few available data of the unseparated $p(γ^*,K^+)Λ$ cross section are well explained by the model. Predictions for the L-T-separation experiment planned with the 12 GeV upgrade at Jefferson Lab are given. The newly-proposed framework predicts an increased magnitude for the transverse structure function, similar to the situation in charged-pion electroproduction. Conclusions: Within a hadronic framework featuring Reggeized background amplitudes, $s$-channel resonance-parton effects can explain the observed magnitude of the unseparated $p(γ^*,K^+)Λ$ cross section at high energies and forward angles. Thereby, no hardening of the kaon electromagnetic form factor is required.
description: 9 pages, 7 figures
IQLIM O`ZGARISHI SHAROITIDA SUVDAN FOYDALANISH TARTIBI
Creators: name: Tursunov, Behruz
name: Pardaev, Sardor
Publisher: name: Zenodo
Year: 2023

description: Ushbu maqola suvdan foydalanish va iqlim o`zgarishi o`rtasidagi murakkab munosabatlarni o`rganadi, rivojlanayotgan iqlim naqshlari tomonidan taqdim etilgan muammolar va imkoniyatlarni ta`kidlaydi. U iqlim o`zgarishining suv tanqisligiga, qishloq xo`jaligiga, ekotizimlarga va infratuzilma barqarorligiga ta`sirini o`rganib, moslashish va ta`sirlarni yumshatish strategiyalarining shoshilinch zarurligini ta`kidlaydi. Global suv-energetika aloqasini ko`rib chiqish va barqaror amaliyotlarni qo`llab-quvvatlash orqali ushbu maqola iqlim o`zgarishini yumshatish bo`yicha sa`y-harakatlarning ajralmas qismi sifatida suv bilan bog`liq muammolarni hal qilish muhimligini ta`kidlaydi.
title: Nitric oxide as a new fumigant for postharvest pest control
Creators: name: Liu, Yong-Biao
name: Yang, Xianbing
Publisher: name: Julius Kühn-Institut
Year: 2018

description: Nitric oxide (NO) is a new fumigant for postharvest pest control. It is effective against all pests tested to date, including external and internal pests of fresh and stored product insects, and mites. Efficacious treatment time ranges from 2 h to 72 h, and NO concentrations range from 0.1% to 5%, depending on species and life stages of the pests.
Nitric oxide fumigation must be conducted under ultralow oxygen conditions because NO reacts with O2 spontaneously to produce nitrogen dioxide (NO2), which is toxic to perishable fresh products. Fresh product fumigation must, therefore, also be terminated by flushing with N2 to dilute NO at the end of fumigation to avoid damage to delicate products by NO2. Nitric oxide fumigation was safe in small-scale tests to postharvest quality of all fresh commodities when terminated with N2 flush. In addition, NO fumigation resulted in better postharvest quality of strawberries and apples as compared with controls, indicating its beneficial effects on postharvest quality of fresh products.
Twenty fresh fruit and vegetables and 10 stored products were fumigated with NO to determine residue levels of nitrate and nitrite. When terminated properly with N2 flush, NO fumigation does not increase nitrate or nitrite levels in fumigated products. NO fumigation was demonstrated to be effective against all pests, safe to fresh products, and has no toxic residues and, therefore, has the potential to be a practical alternative to methyl bromide fumigation for postharvest pest control on both fresh and stored products.
description: Julius-Kühn-Archiv, Nr. 463, Vol. 2 (2018): Proceedings of the 12th International Working Conference on Stored Product Protection (IWCSPP) in Berlin, Germany, October 7-11, 2018
title: Pre-exposure Immunoprophylaxis by Genetically Encoded DMAb anti-OspA Human Monoclonal Antibody to Prevent Lyme Disease
Creators: name: Wang, Yan
name: Flingai, Seleeke
name: Kern, Aurelie
name: Agarwal, Sangya
name: Schiller, Zachary
name: Graybeal, Kaori
name: Esquivel, Rianne
name: Patel, Ami
name: Hu, Linden
name: Weiner, David
name: Klempner, Mark S.
Publisher: name: eScholarship@UMMS
Year: 2017

description: Tick transmission of Borrelia spirochetes to humans results in significant morbidity from Lyme disease. Animal studies have demonstrated that transmission of Borrelia from tick vector to the mammalian host can be blocked by antibodies against outer surface protein A (OspA). We have recently developed borreliacidal human IgG1 monoclonal antibodies (HuMabs) directed against OspA. HuMab 319-44 was borreliacidal against B. burgdorferi (IC50Borreliatransmission after a single dose of 2 mg/kg administered on the day of tick challenge. Since passively administered IgG1 antibodies do not have a sufficient half-life to provide protection for the 6-7 month peak risk period, we investigated a novel approach of vector-mediated gene transfer of HuMabs that could potentially provide protection against Lyme disease during the seasonal risk period.

A modified HuMab, 319-44 mod, expressed by a synthetic DNA plasmid (DMAb) was optimized and characterized in in vitro OspA binding and bactericidal assays. To assess in vivo protection, mice were administered a single DMAb injection into the quadriceps followed by electroporation. The mice were then challenged by B. burgdorferi-infected nymphs. Tissue samples were monitored by dark-field microscopy for spirochete growth. Serum samples were analyzed by ELISA to determine antibody concentrations.

The modified 319-44 DMAb maintained in vitro biological activity comparable to the un-modified wild type antibody, and formulation-based delivery of DMAb resulted in long-term expression. This led to effective pre-exposure prophylaxis preventing transmission of spirochetes in 80% of mice in the murine model of tick-transmitted Lyme disease. These studies represent the first demonstration of employing DNA transfer as a rapid, novel delivery system for biologically relevant functional full-length HuMAbs in an in vivo animal model and provide support for such an approach for pre-exposure immunoprophylaxis to prevent Lyme disease.
Emoção, energia e corpo: unificando mente e sentimento
Creators: name: Reichiano, Centro
name: Henrique Volpi, Jose
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 520302
subject: Clinical psychology

description: Emoções são energias que circulam no organismo, provocam reações fisiológicas corporais que manifestam essas emoções de forma passageira ou quando se repetem frequentemente, tornam-se um padrão de funcionamento. É deste padrão que vem o estudo da couraça de Wilhelm Reich. A mente consciente esconde traumas emocionais e físicos mas eles ficam registrados na pele, no modo de respirar, nos músculos e vísceras fazendo daquela emoção não mais uma sensação e sim uma atitude em resposta ao estímulos externos. O entendimento e o tratamento das couraças fazem as emoções fluírem energeticamente sem impedimentos, flexibilizando e aumentando a vitalidade corporal. Este artigo tem como objetivo expor algumas questões relacionadas com a formação das couraças.
title: Bluefume (HCN) and EDN® as fumigation alternatives to methy bromide for control of primary stored product pests
Creators: name: Stejskal, Vaclav
name: Aulicky, Radek
name: Jonas, Adam
name: Hnatek, Jonas
name: Malkova, Jarmila
Publisher: name: Julius Kühn-Institut
Year: 2018

description: The presented paper provides preliminary results on the fumigation potential of two preparations: Bluefume (HCN - hydrogen cyanide) and EDN®. (Ethane-dinitrile). Their biological efficacy was tested on Granary weevil (Sitophilus granarius; Curculionidae; Coleoptera) as a primary stored product pest in the Czech Republic. In fumigation chamber, we tested temporal survival of various S. granarius strains following exposure of a dose of 9 g.m-3 HCN (Bluefume). We compared differential sensitivity of one laboratory (i.e. sensitive) CRI-strain and 9 field strains collected from the Czech stores and mills. The HCN Ct products required to kill the tested S. granarius strains ranged from CTp= 30.5 g.m-3.h-1 to CTp= 51.7 g.m3.h-1. The efficacy of EDN (30 g.m-3) on various developmental stages S. granarius was tested in a fumigation chamber. No live individual of S. granarius belonging to any life stage was recorded following 18 hours of EDN exposure.
description: Julius-Kühn-Archiv, Nr. 463, Vol. 2 (2018): Proceedings of the 12th International Working Conference on Stored Product Protection (IWCSPP) in Berlin, Germany, October 7-11, 2018
title: Accuracy and Coverage of Using the Assigned International Classification of Diseases, 9th and 10th Revision, Clinical Modification Codes for Detecting Bleeding Events in Electronic Health Record
Creators: name: Wang, Victoria J.
name: McManus, David D.
name: Yu, Hong
Publisher: name: eScholarship@UMMS
Year: 2017

description: Background: Hemorrhages are common events that confer significant risk for in-hospital and post-discharge morbidity and mortality among cardiovascular disease (CVD) patients treated with anticoagulation. International Classification of Diseases, 9th and 10th Revision, Clinical Modification (ICD-9-CM, ICD-10-CM) codes have been widely used in CVD research and managements.

Objective: To determine the accuracy and coverage of assigned ICD-CM codes for reporting bleeding events.

Methods: From the University of Massachusetts Medical School electronic health record (EHR) database we identified 21k patients on anticoagulation with high bleeding risks based on their ICD-9-CM or ICD-10-CM codes. Through manual chart review, we selected one unstructured note (i.e., physical exam findings, historical narratives) from each patient and identified 299 notes with and 102 free from bleeds using convenience sampling. We extracted bleeding events, labeled them as “current” or “historical”, and determined their severity (major/minor, clinically relevant/irrelevant) based on International Society on Thrombosis and Haemostasis (ISTH) criteria. Using the chart extractions as gold standard, we calculated the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of ICD-9-CM and ICD10-CM for detecting bleeding.

Results: In Administrative claims data, ICD-9-CM had a sensitivity of 35.3%, 96.1% specificity, 96.7% PPV, and 31.2% NPV for detecting bleeding, whereas ICD-10-CM codes had a sensitivity of 55.0%, 96.3% specificity, 97. 9% PPV, and 40.6% NPV. Both ICD-CM codes exhibited better sensitivity for detecting current bleeds (41.1%, 73.4%) and major bleeds (50.0%, 62.9%) as compared with historical (32.4%, 43.8%) and minor ones (31.6%, 56.8%).

Conclusions: Half of all bleeding events among patients with CVD were not reflected in administrative claims data. Although the code’s precision is acceptable, the low sensitivity suggests bleeding events may be under-reported by claims data. Our findings have important clinical implications and suggest that novel methods are needed to enhance bleeding identification to improve clinical decision making.
Asynchrone mündliche Prüfungen in der fachdidaktischen Ausbildung von Lehrpersonen - Erfahrungen und Reflexion
Creators: name: Geisen, Martina
name: Zender, Joerg
Publisher: name: Gesellschaft für Didaktik der Mathematik
Year: 2023
Subjects: subject: Digitale Prüfungsformen
subject: Mathematik draußen entdecken
subject: Assessment
subject: Digitalisierung
subject: alternative Prüfungsformate
subject: 510

description: Neben digitalen Lehr- und Lernformaten werden zunehmend Prüfungen digital umgesetzt, wobei diese Prüfungsformen ergebnis- oder prozessorientiert bzw. summativ oder formativ sein können (z. B. Schaper und Kollegen, 2012; Knight, 2001). Die Auswahl der jeweiligen Prüfungsform ist schließlich abhängig von der Lehrveranstaltung und den „Learning Outcomes“ (vgl. Biggs & Tang, 2007). Auch mündliche Prüfungen lassen sich digital umsetzen, indem synchrone mündliche Prüfungen mittels Videokonferenzsystem (z. B. Zoom) abgenommen werden. Obwohl dies eine einfache Möglichkeit darstellt, mündliche Prüfungen digital umzusetzen, lassen sich Materialien (z. B. Schülerdokumente, Anschauungsmittel), die in Präsenz als Ausgangspunkt für Fragen genutzt werden, nicht problemlos und ohne großen Aufwand einsetzen In diesem Beitrag wird eine asynchrone Umsetzung einer mündlichen Prüfung mit Hilfe digitaler Werkzeuge beschrieben und reflektiert.
title: An Innovative Nurse-Managed Transition Clinic for Adolescents and Young Adults with Spina Bifida: A Pilot Study
Creators: name: Alkawaldeh, Mohammad
name: Sherlock, Rebecca
name: Carlos, Estranda
name: Alkhawaldeh, Erika
Publisher: name: eScholarship@UMMS
Year: 2017

description: Background. Transition from pediatric to adult care for patients with complex illness is challenging. The Spina Bifida Center at Boston Children’s Hospital (SBC) has approximately 650 patients, of which 25% (N=162) are ≥ 18 years of age. The SBC has not had a structured paradigm for successful transition. A first transition clinic with our pediatric and adult care urology partners was initiated in August 2016.

Methods. A 20 question (TRAQ: Transition Readiness Assessment Questionnaire) paper survey was distributed to patients in the first Spina Bifida Transition Clinic at Boston Children's Hospital. TRAQ is a validated, patient-centered questionnaire which providers and families can use to assess youths' readiness to transition to adult care.

Results. Seven young adults participated in the Spina Bifida Transition Readiness Assessment Questionnaire (TRAQ). Of the seven patients who took part in the TRAQ survey, 85.7 % (n=6) were males and 14.3% (n=1) were females. 85.7% were white-non-Hispanic or Latino, and 14.3 % were white-Hispanic or Latino. The participants' mean age was 28.1. Of the patients who completed the questionnaires, 61.4 % reported a positive response ("Yes, I have started doing this," or "Yes, I always do this when I need to.") related to their ability level regarding managing medications, appointment keeping, tracking health issues, talking with providers, and managing daily activities. 16.4% reported a negative response ("No, I do not know how,") related to the domains mentioned above, and 22.1% had a negative response but were either willing to learn or already learning how to manage and develop skills needed for the transition to adult care.

Conclusion. Transition is a multi-step process. We found that successful transition for the patient and family requires investment from pediatric and adult providers, involvement of social work and the support of local spina bifida association.
Welche Merkmale zeigen Instruktionssensitivität von Testitems?
Creators: name: Schönenberger, Stephan
name: List, Marit Kristine
name: Naumann, Alexander
name: Leininger, Stephanie
name: Hochweber, Jan
name: Hartig, Johannes
Publisher: name: Gesellschaft für Didaktik der Mathematik
Year: 2023
Subjects: subject: Unterrichtsqualität
subject: Instruktionssensitivität
subject: Aufgabenmerkmale
subject: 510

description: Anhand eines Tests zu linearen Funktionen und Gleichungen wurden Testitems entwickelt, die einerseits den Lernzuwachs abbilden und andererseits in Beziehung zu Unterrichtsqualitätsmerkmalen stehen sollen, also instruktionssensitiv sind (Polikoff, 2010). Eine zentrale Frage dabei ist, welche Merkmale der Testitems diese Beziehung beeinflussen können (Naumann, et.al.; 2019). Durch ein Expertenrating wurden Merkmale bestimmt, für welche eine Wechselwirkung vermutet werden kann. Bestimmte Merkmale wurden systematisch in der Testentwicklung zum konkreten Lerngegenstand variiert. In einer spezifischen Unterrichtsreihe in Hessen und der Schweiz untersuchen wir mit einem Prä-Post-Design, wie diese Itemmerkmale mit dem geschätzten Lernzuwachs der Schüler*innen in dem Lerngebiet unter Berücksichtigung von Merkmalen der Unterrichtsqualität in Zusammenhang stehen. Im Fokus steht insbesondere die Itementwicklung im Rahmen des Projekts (Rodriguez, 2017).
title: Effect of Exercise Training on Microvascular Function in African American and Caucasian Women
Creators: name: Yan, Huimin
name: Melendex-Rosado, Keyshla M.
name: Hickner, Robert C.
Publisher: name: eScholarship@UMMS
Year: 2017

description: African Americans (AA), especially women, exhibit long-standing disparities in cardiovascular disease (CVD) and obesity. The prevalence of endothelial dysfunction, directly linked to hypertension, is considerably greater in AA than Caucasians (C). Vascular smooth muscle function (mediating endothelium-independent vasodilation) is also related to CVD risk factors but is underappreciated because most literature in C suggest endothelium-independent vasodilatory response is resistance to change with disease (hypertension) or exercise training. Furthermore, the regulation of local skeletal muscle blood flow (an important site of peripheral resistance) has not been sufficiently assessed. Microdialysis is the only method that allows monitoring of microvascular blood flow while affecting the local tissue with pharmacological agents in the absence of systemic, or organ level, effects in humans. Microvascular blood flow was assessed by microdialysis in vivo in skeletal muscle before and after 12 weeks of aerobic exercise training in young, obese AA and C women. Our preliminary data suggested that microvascular endothelial function, assessed by percent change in blood flow from basal (Δ Blood Flow) in response to acetylcholine perfusion was improved in both obese AA (n=5) and obese C (n=4) women. Microvascular endothelium-independent blood flow, assessed by percent change in blood flow from baseline (Δ Blood Flow) upon addition of sodium nitroprusside to the perfusate, was improved in AA (n=3) but not in C (n=9) women.

Exercise training may improve endothelium-dependent vascular function in both AA and C, but improve endothelium-independent vascular function only in AA. Results of this study have potential to inform preventive interventions including lifestyle and pharmacological approaches designed to reduce disparities in hypertension and end-organ damage.
Barking Up the Wrong Tree? Industry Funding of Academic Research
Publisher: name: Online Ethics Center
Year: 2006
Subjects: Collaboration
Conflict of Interest
Environmental Justice
Ethics and Society
Mentors and Trainees
Research and Practice
Sustainability

description: This case discusses issues such as the conflict of interest that arises from the impact of private industry funding, management of a research lab, student-mentor/ post-doc workplace relationships, and integrity of the researcher.
Rekonstruktion von Denkprozessen zum Sinusbegriff in kooperativen Problemlösesituationen
Creators: name: Katter, Valentin
Publisher: name: Gesellschaft für Didaktik der Mathematik
Year: 2023
Subjects: subject: Trigonometrie
subject: Sinus
subject: Grundvorstellungen
subject: Rekonstruktion
subject: Lehramtsstudierende
subject: Argumentation
subject: Erklärung
subject: 510

description: Das Lernen und Lehren der Trigonometrie beinhaltet einige aus didaktischer Sicht besondere Herausforderungen. Diese Herausforderungen sind zum einen darin begründet, dass Funktionswerte im Allgemeinen nicht mithilfe endlich vieler Rechenoperationen bestimmt werden können, zum anderen darin, dass der Sinusbegriff in verschiedenen Sachzusammenhängen genutzt werden kann und so unterschiedliche Bedeutungen bekommt. Erkennbar wird dieser Bedeutungswechsel beispielsweise bei der Anwendung am Einheitskreis und am rechtwinkligen Dreieck. Darüber hinaus wird der Sinus eingesetzt um periodische Prozesse zu modellieren und er ist ein wichtiges innermathematisches Werkzeug bei der Fourieranalyse. Diese und weitere Zusammenhänge bilden die Grundlage für eine Reihe funktionsklassenspezifischer Grundvorstellungen, die dem Sinus aus normativer Sicht zugeschrieben werden können (Frohn & Salle, 2017) und über die bekannten allgemeinen funktionalen Grundvorstellungen (Vollrath, 1989) hinaus gehen. In diesem Beitrag wird der Frage nachgegangen inwieweit diese neuen Grundvorstellungen geeignet sind um mathematische Arbeitsprozesse von Studierenden zu analysieren.
title: Enhancement of the Abscopal Effect in Radiotherapy by In-situ Delivered CD40 Antibody: Pancreatic Adenocarcinoma Model
Creators: name: Yasmin-Karim, Sayeda
name: Moreau, Michele
name: Ngwa, Wilfred
Publisher: name: eScholarship@UMMS
Year: 2017

description: Metastasis is the cause of death in most cancers. It has been observed by Mole and others that radiotherapy at one site may lead to regression of metastatic cancer at other sites, which were not irradiated, this phenomenon is called ‘abscopal’ effect. Unfortunately, this regression is not predictable.

Few studies observed some enhancement by systemic application of immunoadjuvants, which also has limited application because of generalized adverse effect. The purpose of this study is to evaluate the enhancing and abscopal effect of radiotherapy by in-situ delivered anti-CD40 in the treatment of pancreatic cancer.

A syngeneic mouse model of pancreatic adenocarcinoma was generated in C57/BL6 background mouse using Panc02 cell lines in both flanks. The palpable sized tumors of left flanks were treated as four different randomized cohorts: control with no treatment, direct treatment with 5 Gy of radiation, intra tumor treatment with CD40 antibody, and in combination. Tumor growth was measured on both sides.

Result shows that in-situ application of CD40 antibody significantly enhances the effect of radiotherapy. Reduction of tumor volume was observed in both sides. The treated tumors (left) show average of 75% reduction of tumor volume by combination treatment compare to 32% reduction by radiation alone. On the untreated side (right), it was 86% reduction with combination treatment compare to 20% reduction with the radiation alone which may be reminiscent of an abscopal effect. This result shows potential for translational studies to significantly extend the use of radiotherapy for the treatment of both localized and metastatic cancers.
title: Improved analysis of propylene oxide, propylene chlorohydrin and propylene bromohydrin
Creators: name: Hall, Wiley A.
name: Walse, Spencer S.
name: Jimenez, Leonel
Publisher: name: Julius Kühn-Institut
Year: 2018

description: The benefits and deficiencies of several methods of analysis for PPO and PXH, including the aqueous extraction used in ASTA method 23.1 and the MTBE extraction method previously reported by the authors, will be discussed. Novel methods utilizing dynamic headspace extraction and solid phase microextraction (SPME) will also be reported with particular emphasis on preventing artefactual effects. Preliminary experiments have found that dynamic headspace sampling can lower detection limits by up to 3 orders of magnitude.
description: Julius-Kühn-Archiv, Nr. 463, Vol. 2 (2018): Proceedings of the 12th International Working Conference on Stored Product Protection (IWCSPP) in Berlin, Germany, October 7-11, 2018
title: Using mHealth App to Support TKR Decision Making for Knee Arthritis Patients
Creators: name: Zheng, Hua
name: Tulu, Bengisu
name: Choi, Wonchan
name: Franklin, Patricia D.
Publisher: name: eScholarship@UMMS
Year: 2017

description: Introduction: Mobile health (mHealth) technology can be used to integrate into medical decision making for patients with advanced knee arthritis. We explored patient preferences on content and design of a mobile health app to facilitate daily symptom capture and summary feedback reporting, in order to inform treatment decisions, including use of total knee replacement surgery (TKR).

Methods: We developed an Android-based smart phone app for knee arthritis patients to assess arthritis symptoms and individual readiness for TKR surgery. Patient focus groups were conducted to gather requirements for mHealth app development and to refine the design and content of the app. Clinician (physical therapist, surgeon) interviews were conducted to understand clinician expectations from the summary trend report generated by the app.

Results: Sixteen patients attended focus groups with an average age of 67 and 63% female, and three clinicians participated in clinician interviews. The preliminary findings revealed that the patients preferred easy tap user interfaces to multi-tap or slider methods, and vertical question layout to horizontal orientation. Patients liked to be engaged by progress feedback reports and educational tips. Both patients and clinicians found a trended outcome summary report helpful which provides more precise details on whether and how the symptoms are changing over time.

Discussion: User input can inform the design and implementation of mHealth technology to deliver tailored knowledge to patients through a user-defined, patient-centered smart phone app. The tool will support future knee arthritis patient decisions regarding the need for, and timing of TKR surgery.
Minisymposium 04: Alternative Prüfungsformate - digital und kompetenzorientiert
Creators: name: Geisen, Martina
name: Zender, Joerg
name: Buchholtz, Nils
Publisher: name: Gesellschaft für Didaktik der Mathematik
Year: 2023
Subjects: subject: Assessment
subject: alternative Prüfungsformate
subject: Digitalisierung
subject: 510

description: Während der Covid19-Pandemie 2020/2021 war an Universitäten und Hochschulen aufgrund von Hygiene- und Abstandsregeln größtenteils keine Präsenzlehre möglich. Studierende waren durch die Verlagerung der Lehre in das Digitale in besonderer Weise betroffen, da z. B. schulische Praxiserfahrungen für Lehramtsstudierende nicht in Präsenz durchführbar waren. Generell waren auch Präsenzprüfungen im Studium, die die im regulären Studium erworbenen Kompetenzen kriteriell überprüfen, vielfach nicht durchführbar, weshalb kurzfristig neue Formate im Prüfungswesen erforderlich waren, und Prüfungsleistungen neu gedacht und entsprechend auch digital konzipiert werden mussten. Dieses notwendige Umdenken hinsichtlich neuer Prüfungsformate bietet für die zukünftige Überprüfung neu gewonnener Kompetenzen von Studierenden Chancen für eine integrierte und an den beruflichen Anforderungen von Lehrpersonen orientierte Leistungsmessung. Die gewissermaßen aus der Not geborene Transformation von analogen zu digitalen Prüfungsformaten birgt aber auch Schwierigkeiten, z. B. auf normativer, technischer, operationaler oder datenschutzrechtlicher Ebene. In Bezug auf bereits eingesetzte Prüfungsformate ergibt sich aus der vorliegenden Forschungslage ein differenziertes Bild. So sagten z. B. Lin und Dwyer dem computergestützten Prüfen bereits 2006 ein großes Potential voraus, wobei allerdings die prüfungsrechtliche Dimension nicht außer Acht gelassen werden darf (Fischer & Dieterich, 2020). Auch Weiterentwicklungen klassischer Prüfungsformate wie etwa Multiple-Choice scheint mithilfe von Technik sinnvoll möglich und kann Reflexionsanlässe in Prüfungen schaffen (Gardner-Medvin & Curtin, 2007). Im Folgenden werden die im Symposium diskutierten Prüfungsformen vorgestellt und diskutiert.
title: Direct-to-Patient PRO Collection to Support Quality Improvement in TJR
Creators: name: Zheng, Hua
name: Lemay, Celeste A.
name: Yang, Wenyun
name: Franklin, Patricia D.
Publisher: name: eScholarship@UMMS
Year: 2017

description: Introduction: Patient-reported outcomes (PROs) are widely used in orthopedic clinical research to evaluate quality of care. However, it is difficult to capture complete post-operative PRO data through surgeon office visits. The UK and Sweden collect post-TJR PRO measures directly from patients in their homes. We compared two US post-operative PRO collection processes- PROs in clinic at scheduled office visits and direct-to-patient collection, to evaluate timing and completeness of both approaches.

Methods: At a large TJR center that has collected PROs at office visits routinely for years, post-TJR patients complete a PRO survey on a computer at follow-up clinic visits. In contrast, the national FORCE-TJR cohort manages post-operative PRO surveys across dozens of offices by sending PROs to patients directly via web-based questionnaires or scannable paper forms. We calculated post-operative PRO response rates and timing from these two approaches and compared patient physical outcomes between them.

Results: In the clinic, 892 patients had TJR surgery during the study period. Of these, 392 (44%) completed post-operative surveys; 115 (29%) between 5 months and 7 months after surgery, and 85 (22%) after 7 months. Direct to patient PRO surveys were centrally distributed in month 5 after surgery. Of 11,702 TJR patients, 8283 (71%) completed the PRO survey within 5 to 9 months post-op. Of these, 90% were returned between 5 and 7 months. SF36 PCS scores were comparable between these two approaches.

Discussion: While PRO collection at the office visit can support individual patient care decisions, patients return to the surgeon office at varied time points after TJR based on their recovery progress and convenience. Direct to patient PRO collection with appropriate retention processes can lead to uniform data timing and optimal completeness. Quality monitoring programs will benefit from consistent data across providers and should consider these factors in designing PRO procedures.
Tumour Control Probability in Cancer Stem Cells Hypothesis
Creators: name: Dhawan, A.
name: Kohandel, M.
name: Hill, R. P.
name: Sivaloganathan, S.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Quantitative Methods (q-bio.QM)
subject: Tissues and Organs (q-bio.TO)
subject: FOS: Biological sciences

description: The tumour control probability (TCP) is a formalism derived to compare various treatment regimens of radiation therapy, defined as the probability that given a prescribed dose of radiation, a tumour has been eradicated or controlled. In the traditional view of cancer, all cells share the ability to divide without limit and thus have the potential to generate a malignant tumour. However, an emerging notion is that only a sub-population of cells, the so-called cancer stem cells (CSCs), are responsible for the initiation and maintenance of the tumour. A key implication of the CSC hypothesis is that these cells must be eradicated to achieve cures, thus we define TCP_S as the probability of eradicating CSCs for a given dose of radiation. A cell surface protein expression profile, such as CD44high/CD24low for breast cancer, is often used as a biomarker to monitor CSCs enrichment. However, it is increasingly recognized that not all cells bearing this expression profile are necessarily CSCs, and in particular early generations of progenitor cells may share the same phenotype. Thus, due to the lack of a perfect biomarker for CSCs, we also define a novel measurable TCP_CD+, that is the probability of eliminating or controlling biomarker positive cells. Based on these definitions, we use stochastic methods and numerical simulations to compare the theoretical TCP_S and the measurable TCP_CD+. We also use the measurable TCP to compare the effect of various radiation protocols.
description: 18 pages, 5 figures
title: Monitoring of post-harvest fumigation with Gasmet Multikomponent FTIR gas detection systems
Creators: name: Arnold, Frank
Publisher: name: Julius Kühn-Institut
Year: 2018

description: Julius-Kühn-Archiv, Nr. 463, Vol. 2 (2018): Proceedings of the 12th International Working Conference on Stored Product Protection (IWCSPP) in Berlin, Germany, October 7-11, 2018
Lerngelegenheiten zum Teile-Ganzes-Konzept in Mathematikschulbüchern der ersten Jahrgangsstufe
Creators: name: Lenz, Katja
name: Wittmann, Gerald
Publisher: name: Gesellschaft für Didaktik der Mathematik
Year: 2023
Subjects: subject: Teile-Ganzes-Konzept
subject: Zahlzerlegungen
subject: Rechnenlernen
subject: Schulbuchanalyse
subject: qualitative Inhaltsanalyse
subject: Grundschule
subject: Arithmetik
subject: Sonstiges
subject: 510

description: Die Entwicklung des Teile-Ganzes-Konzepts ist von grundlegender Bedeutung für die Entwicklung des Zahlbegriffs und das Rechnenlernen und deshalb eine zentrale Aufgabe des arithmetischen Anfangsunterrichts. Gleichwohl besteht bislang wenig Erkenntnis darüber, welche Lerngelegenheiten Schulbücher für die 1. Klasse bezüglich des Teile-Ganzes-Konzepts bieten.
title: Roux-en-Y Gastric Bypass Surgery Regulates Mitochondrial Dynamics Proteins in Primary Human Myotubes Derived from Severely Obese Humans
Creators: name: Zou, Kai
name: Hinkley, J. Matthew
name: Park, Sanghee
name: Zheng, Donghai
name: Dohm, G. Lynis
name: Houmard, Joseph A.
Publisher: name: eScholarship@UMMS
Year: 2017

description: Mitochondrial dynamics including mitochondrial fission (e.g., Dynamin-related protein 1 (Drp1) and Fission 1 (Fis1)) and fusion (e.g., Mitofusin 2 (MFN 2)) regulates mitochondrial homeostasis. Defects in mitochondrial dynamics are suggested to contribute to skeletal muscle mitochondrial dysfunction and insulin resistance associated with severe obesity. Roux-en-Y gastric bypass (RYGB) surgery markedly improves metabolic health as indicated by enhanced substrate oxidation and insulin action in skeletal muscle. However, the underlying cellular mechanisms responsible for these are unclear and could possibly be due to the improvement of mitochondrial dynamics.

PURPOSE: The purpose of this study was to determine whether RYGB surgery improves mitochondria dynamics proteins in primary human myotubes from severely obese humans.

METHODS: Primary skeletal muscle cells were isolated from muscle biopsies obtained from six lean subjects (BMI = 23.4 ± 0.6 kg/m2) and six RYGB patients prior to, 1-month and 7-months after surgery (BMI = 50.2 ± 2.0, 43.2 ± 2.8 and 35.7 ± 2.2 kg/m2, respectively) and were differentiated to myotubes. On day 7 of differentiation, myotubes were harvested for further assessing the expressions of mitochondria dynamics proteins.

RESULTS: Before surgery, Drp1Ser616 phosphorylation and Fis1 expression were significantly higher in myotubes derived from severely obese patients when compared to lean controls (41% and 26%, respectively, P < 0.05). While there were no improvements at 1-month post-surgery, Drp1Ser616 phosphorylation and Fis1 expression were significantly decreased in myotubes from severely obese humans at 7-months post-surgery (Pre vs. 7-months post: 0.046 ± 0.004 vs. 0.035 ± 0.003; 0.023 ± 0.008 vs. 0.014 ± 0.003 AU; respectively, P < 0.05), and not statistically different from lean controls. However, MFN2 expression did not change post-surgery in comparison to pre-surgery.

CONCLUSION: These data suggest that RYGB surgery reduces obesity-induced rise in mitochondrial fission, but not fusion in primary human myotubes derived from severely obese humans.
title: Patient-Perceived Breakdowns in Care: Informing Clinician Responses
Creators: name: Fisher, Kimberly A.
Publisher: name: eScholarship@UMMS
Year: 2017

description: The presentation will introduce the audience to the topic of patient-perceived breakdowns in care, with a focus on breakdowns in the critical care setting. It will highlight how patient-perceived breakdowns in care can impede the delivery of patient-centered care, including shared decision-making. It will conclude by exploring the central role of frontline clinicians in responding to patient reports of breakdowns in care, including potential facilitators and barriers to addressing patient concerns about breakdowns in care. This presentation is part of the mini-symposium entitled "Building Bridges to "Cross the Quality Chasm": The Challenges of Engaging Clinicians in Patient-Centered Care."
HVAC Design Problem
Publisher: name: Online Ethics Center
Year: 2006
Subjects: Controversies
Employer/Employee Relationships
Energy
Engineer/Client Relationships
Environmental Justice
Ethics and Society
Research and Practice
Sustainability
Workplace Ethics

description: As an engineer for an energy consulting company, you determine which materials should be used in the heating, ventilation, and air conditioning of buildings. Ethical issues arise when the contractor's designs fail to meet California Energy Standards.
title: Determination of safe storage moisture content of commercial maize (Zea mays) seeds during hermetic storage
Creators: name: Abadia, Bernadette
name: Bartosik, Ricardo
Publisher: name: Julius Kühn-Institut
Year: 2018

description: Germination declines during storage and meeting official standards (90% limit) can be challenging for the seed industry. Hermetic storage, through the establishment of self-modified atmospheres has shown to preserve germination in high-moisture maize seeds, but in the range of the low-moisture contents (m.c.) used by the seed industry, the relationship between hermetic storage and seed quality has not been fully studied. The aim of this work was to determine the safe storage m.c. of commercial maize seeds during hermetic storage considering both germination and microbiological aspects. Maize seeds with 95% initial germination were conditioned to m.c.s. between 11.5 and 14.5% and stored hermetically at 25ºC for 6 months. Germination, % oxygen, % infected grains, and colony forming units (CFU) were evaluated. Germination declined with increasing m.c.s, dropping to 50% at 14.5% m.c. Microflora respiration started to be detected at 13.5% m.c. and an anaerobic self-modified atmosphere was reached at 14.5% m.c. Despite the higher relative humidity, % infected grains and CFU count at 14.5% m.c. were lower than at 13.5%, probably due to the suppressive effect of the anaerobic atmosphere. In conclusion, 11.5% was a safe storage m.c. as it preserved germination above marketing requirements without microbiological risk. Hermetic storage was useful to generate self-modified atmospheres for m.c.s above 13.5%, but these self-modified atmospheres were not effective to protect germination. Further research on the effects of controlled and self-modified atmospheres on the quality of different maize genotypes is needed to evaluate the benefit of hermetic storage of commercial seeds.
description: Julius-Kühn-Archiv, Nr. 463, 978-3-95547-073-9 Vol. 2 (2018): Proceedings of the 12th International Working Conference on Stored Product Protection (IWCSPP) in Berlin, Germany, October 7-11, 2018
Berücksichtigung von Lernvoraussetzungen als diagnostische Fokussierung von Lehrkräften
Creators: name: Rösike, Kim-Alexandra
Publisher: name: Gesellschaft für Didaktik der Mathematik
Year: 2023
Subjects: subject: professional vision
subject: kategoriengeleitete Diagnose
subject: Expertise
subject: Professionalisierungsforschung
subject: Lehrerbildung (1., 2. und 3. Phase)
subject: interdisziplinär
subject: Sonstiges
subject: 510

description: Die Diagnose der Lernvoraussetzungen von Schülerinnen und Schülern ist eine der zentralen Anforderung an Lehrkräfte im Rahmen ihrer professionellen Tätigkeit (Prediger & Buró, 2021). Ihre professional vision (Van Es & Sherin, 2006) wird dabei gefiltert durch fachdidaktische und pädagogische Kategorien, z.B. einzelne Kompetenzaspekte oder motivational-volitionale Aspekte. Durch die Wahrnehmung und Bewertung von Lernendenleistungen unter Relevantsetzung einzelner dieser Kategorien fokussieren und beurteilen die Lehrkräfte dabei unterschiedliche Lernvoraussetzungen der Lernenden. Diese Fokussierung ist Grundlage für das weitere adaptive Agieren in der Interaktion mit den Lernenden und somit die Grundlage für pädagogische und fachdidaktische Impulssetzung. Die Fokussierung der Lehrkräfte im Sinne ihrer professional vision lässt also Rückschlüsse auf die Wahrnehmung und Ausgestaltung von Unterricht und Förderungen ziehen.
Heat Transfer Problem
Publisher: name: Online Ethics Center
Year: 2006
Subjects: Employer/Employee Relationships
Engineer/Client Relationships
Ethics and Society
Law and Public Policy
Public Health and Safety
Public Well-being
Research and Practice
Safety
Social Responsibility
Workplace Ethics

description: An engineer, you work for a consulting firm responsible for the renovation of old office buildings for a military base. A new regulation concerning wall materials goes into effect next year. The wall you are working on will not meet the new regulations. Conflict arises when there are differing opinions regarding which regulations to follow.
title: Agenda: 2017 UMass Center for Clinical and Translational Science Research Retreat
Creators: name: UMCCTS Research Retreat
Publisher: name: eScholarship@UMMS
Year: 2017

description: Agenda for the 7th annual UMass Center for Clinical and Translational Science Research Retreat, held Tuesday, May 16, 2017 at the University of Massachusetts Medical School, Worcester, MA.
Mt. Dioxin
Publisher: name: Online Ethics Center
Year: 2006
Subjects: Employer/Employee Relationships
Engineer/Client Relationships
Environmental Justice
Ethics and Society
Research and Practice
Risk
Social Justice
Sustainability
Workplace Ethics

description: An abandoned wood-treating facility must undergo a Superfund cleanup. The case history and other data are presented in order to provide insight into numerical and ethical problems in this situation.

This case is suitable for a junior level fluid mechanics class, or a senior level course on ethics and professionalism.
Vorstellungen von Schülerinnen und Schülern von der Bedeutung der Mathematik in einem Studium
Creators: name: Rohenroth, Dunja
name: Neumann, Irene
name: Heinze, Aiso
Publisher: name: Gesellschaft für Didaktik der Mathematik
Year: 2023
Subjects: subject: Übergang Schule-Hochschule
subject: Studierfähigkeit
subject: Mathematik
subject: Mathematik in Nicht-MINT-Fächern
subject: Sek II
subject: interdisziplinär
subject: 510

description: Die Bildungsziele des Unterrichts der gymnasialen Oberstufe umfassen neben der Trias einer vertieften Allgemeinbildung, allgemeinen Studierfähigkeit und wissenschaftspropädeutischen Bildung auch eine angemessene Information über Anforderungen des Studiums (KMK, 2006). Dennoch zeigen verschiedene Studien auf, dass der Informationsstand vieler Studienanfänger* innen über die Anforderungen ihres Studiums häufig unzureichend ist (Lewin et al., 2000; Oepke & Eberle, 2016). Dieser defizitäre Informationsstand mündet vielfach in einem Studienabbruch. In mathematisch-naturwissenschaftlichen Studienfächern und den Wirtschafts- und Sozialwissenschaften sind falsche Erwartungen für 10 % der Studienabbrecher*innen sogar abbruchentscheidend (Heublein et al., 2010). Auch mit Blick auf mathematische Anforderungen im Studium bemängeln Hochschullehrende Informationsdefizite. So merkt bspw. eine Dozentin des Studiengangs Wirtschaftspolitischer Journalismus an, dass „angehende Studierende besser darüber aufgeklärt werden [sollten], was auf sie zukommt. Viele unserer Teilnehmer: innen sind völlig überrascht von der Tatsache, dass der Studiengang recht mathematisch aufgebaut ist.“ (Neumann et al., 2021, S. 6) Auch nehmen Hochschullehrende eine Vermeidungstaktik der Studierenden wahr: „Zudem ist mein Eindruck, dass sich die meisten Studierenden für einen Studiengang der Sozialen Arbeit bzw. Sozialpädagogik entschieden haben, um mathematische Anforderungen zu vermeiden.“ (Neumann et al., 2021, S. 6).
The Ising model and Special Geometries
Creators: name: Boukraa, S.
name: Hassani, S.
name: Maillard, J-M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: G.1.7
subject: 34M55, 47E05, 81Qxx, 32G34, 34Lxx, 34Mxx, 14Kxx

description: We show that the globally nilpotent G-operators corresponding to the factors of the linear differential operators annihilating the multifold integrals $χ^{(n)}$ of the magnetic susceptibility of the Ising model ($n \le 6$) are homomorphic to their adjoint. This property of being self-adjoint up to operator homomorphisms, is equivalent to the fact that their symmetric square, or their exterior square, have rational solutions. The differential Galois groups are in the special orthogonal, or symplectic, groups. This self-adjoint (up to operator equivalence) property means that the factor operators we already know to be Derived from Geometry, are special globally nilpotent operators: they correspond to "Special Geometries". Beyond the small order factor operators (occurring in the linear differential operators associated with $ χ^{(5)}$ and $ χ^{(6)}$), and, in particular, those associated with modular forms, we focus on the quite large order-twelve and order-23 operators. We show that the order-twelve operator has an exterior square which annihilates a rational solution. Then, its differential Galois group is in the symplectic group $ Sp(12, \mathbb{C})$. The order-23 operator is shown to factorize in an order-two operator and an order-21 operator. The symmetric square of this order-21 operator has a rational solution. Its differential Galois group is, thus, in the orthogonal group $ SO(21, \mathbb{C})$.
description: 33 pages
Challenger O-Ring Data Analysis
Publisher: name: Online Ethics Center
Year: 2006
Subjects: Catastrophes, Hazards, Disasters
Employer/Employee Relationships
Ethics and Society
Lab and Workplace Safety
Research and Practice
Safety
Workplace Ethics

description: This case provides an analysis of the O-ring data from the Challenger Disaster and argues for a launch scrub. Suitable for courses in applied statistics, material, and general engineering levels 1-4.
Power requirements for cosmic ray propagation models involving re-acceleration and a comment on second order Fermi acceleration theory
Creators: name: Thornbury, Andrew
name: Drury, Luke O'C.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We derive an analytic expression for the power transferred from interstellar turbulence to the Galactic cosmic rays in propagation models which include re-acceleration. This is used to estimate the power required in such models and the relative importance of the primary acceleration as against re-acceleration. The analysis provides a formal mathematical justification for Fermi's heuristic account of second order acceleration in his classic 1949 paper.
description: 3 pages, submitted to MNRAS. some additions as requested by the referee