cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Analysis of Single Nucleotide Polymorphisms and Radiation Sensitivity of the Lung Assessed With an Objective Radiologic Endpoin
Creators: name: Owzar, Kouros
name: Vujaskovic, Zeljko
name: Jackson, Isabel L.
name: Kelsey, Chris R.
name: Marks, Lawrence B.
name: Langdon, Scott
name: Das, Shiva
name: Hubbs, Jessica
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: To explore the possibility that underlying genetic susceptibility influences radiation-induced lung injury, we studied pulmonary damage after radiation therapy for lung cancer and single nucleotide polymorphisms implicated in radiation sensitivity. An objective radiologic method (perfusion single photon emission computed tomography) was used to assess radiation sensitivity. An association between single nucleotide polymorphisms in XRCC1 and BRCA1 and radiation sensitivity of the lungs was noted.
(400948) Kenneth Alexander Park
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(400946) John Stewart Park
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Multimodality imaging of midtarsal joint injuries. A biomechanic-oriented didactic approach.
Creators: name: Viglino, Umberto
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Anatomy
subject: Extremities
subject: Musculoskeletal joint
subject: MR
subject: Ultrasound
subject: Diagnostic procedure
subject: Education
subject: Education and training
subject: Trauma

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To illustrate the normal anatomy of the midtarsal joint stabilizing ligaments and to describe the appearance among different imaging modalities. Midtarsal ligaments traumatic injuries US-MRI findings will be elucidated with anatomical schemes, with...
The Simultaneous Strong Metric Dimension of Graph Families
Creators: name: Estrada-Moreno, A.
name: García-Gómez, C.
name: Ramírez-Cruz, Y.
name: Rodríguez-Velázquez, J. A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05C12, 05C05

description: Let ${\cal G}$ be a family of graphs defined on a common (labeled) vertex set $V$. A set $S\subset V$ is said to be a simultaneous strong metric generator for ${\cal G}$ if it is a strong metric generator for every graph of the family. The minimum cardinality among all simultaneous strong metric generators for ${\cal G}$, denoted by $Sd_s({\cal G})$, is called the simultaneous strong metric dimension of ${\cal G}$. We obtain general results on $Sd_s({\cal G})$ for arbitrary families of graphs, with special emphasis on the case of families composed by a graph and its complement. In particular, it is shown that the problem of finding the simultaneous strong metric dimension of families of graphs is $NP$-hard, even when restricted to families of trees.
description: arXiv admin note: text overlap with arXiv:1312.1987 by other authors
Stable scalable control of soliton propagation in broadband nonlinear optical waveguides
Creators: name: Peleg, Avner
name: Nguyen, Quan M.
name: Huynh, Toan T.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Pattern Formation and Solitons (nlin.PS)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We develop a method for achieving scalable transmission stabilization and switching of $N$ colliding soliton sequences in optical waveguides with broadband delayed Raman response and narrowband nonlinear gain-loss. We show that dynamics of soliton amplitudes in $N$-sequence transmission is described by a generalized $N$-dimensional predator-prey model. Stability and bifurcation analysis for the predator-prey model are used to obtain simple conditions on the physical parameters for robust transmission stabilization as well as on-off and off-on switching of $M$ out of $N$ soliton sequences. Numerical simulations for single-waveguide transmission with a system of $N$ coupled nonlinear Schrödinger equations with $2 \le N \le 4$ show excellent agreement with the predator-prey model's predictions and stable propagation over significantly larger distances compared with other broadband nonlinear single-waveguide systems. Moreover, stable on-off and off-on switching of multiple soliton sequences and stable multiple transmission switching events are demonstrated by the simulations. We discuss the reasons for the robustness and scalability of transmission stabilization and switching in waveguides with broadband delayed Raman response and narrowband nonlinear gain-loss, and explain their advantages compared with other broadband nonlinear waveguides.
description: 37 pages, 7 figures, Eur. Phys. J. D (accepted)
title: A close up on the imaging of orbital meningioma, multiple presentations and one goal: preserving vision.
Creators: name: Masmoudi, Jaouhar
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Eyes
subject: Neuroradiology brain
subject: Oncology
subject: CT
subject: MR
subject: Education
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Illustrate different imaging presentations of orbital meningioma in both MRI and CT findings: primary orbital meningioma, secondary orbital meningioma, sphenoid wing en plaque meningioma, locally aggressive meningioma. Detail the role of MRI imaging...
A symplectic rearrangement of the four dimensional non-geometric scalar potential
Creators: name: Shukla, Pramod
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We present a symplectic rearrangement of the effective four-dimensional non-geometric scalar potential resulting from type IIB superstring compactification on Calabi Yau orientifolds. The strategy has two main steps. In the first step, we rewrite the four dimensional scalar potential utilizing some interesting flux combinations which we call new generalized flux orbits. After invoking a couple of non-trivial symplectic relations, in the second step, we further rearrange all the pieces of scalar potential into a completely `symplectic-formulation' which involves only the symplectic ingredients (such as period matrix etc.) without the need of knowing Calabi Yau metric. Moreover, the scalar potential under consideration is induced by a generic tree level Kähler potential and (non-geometric) flux superpotential for arbitrary numbers of complex structure moduli, Kähler moduli and odd-axions. Finally, we exemplify our symplectic formulation for the two well known toroidal examples based on type IIB superstring compactification on ${\mathbb T}^6/{({\mathbb Z}_2 \times {\mathbb Z}_2)}$-orientifold and ${\mathbb T}^6/{{\mathbb Z}_4}$-orientifold.
description: version 3: 43 pages, some improvements, to appear in JHEP
Supplementary methods and results - species specific impacts of suspended sediments on gill structure and function in coral reef fishes.
Creators: name: Hess, Sybille
name: Leteisha Prescott
name: Hoey, Andrew S.
name: McMahon, Shannon
name: Wenger, Amelia S.
name: Rummer, Jodie L.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Science
subject: Ecology

description: This file contains supplementary information on larval rearing conditions, the experimental set-up for sediment resuspension, respirometry protocol, gill analysis, and additional results.
Phase I Clinical Trial of Valacyclovir and Standard of Care Cyclophosphamide in Children With Endemic Burkitt Lymphoma in Malawi
Creators: name: Mechanic, Oren
name: Tang, Weihua
name: Mwansambo, Charles
name: Nguluwe, Nelson
name: Olson, Daniel
name: Hosseinipour, Mina
name: Gulley, Margaret L.
name: Shores, Carol
name: Gold, Stuart H.
name: Wokocha, Clifford
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Treatment options for Epstein-Barr virus (EBV)-associated Burkitt lymphoma in Africa are limited because of chemotherapy-associated toxicity. Since other EBV-associated diseases respond to antiviral agents, we investigated adding an antiviral agent, valacyclovir, to the current chemotherapy regimen in Malawi. In this phase I safety study, we showed that cyclophosphamide combined with valacyclovir was safe. Phase II efficacy trials should now be undertaken.
Histological characteristics of singleton placentas delivered before the 28th week of gestation
Creators: name: Hecht, Jonathan L.
name: Bhan, Ina
name: Leviton, Alan
name: Senagore, Patricia Kaman
name: Doss, Barbara J.
name: Roberts, Drucilla
name: Husain, Aliya
name: Ross, Dennis W.
name: Allred, Elizabeth N.
name: Zambrano, Eduardo
name: Pflueger, Solveig M.V.
name: Livasy, Chad A.
name: Chang, Chung Ho
name: Kliman, Harvey J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The placenta is a record of the fetal environment and its examination may provide information about the baby’s subsequent growth and development. We describe the histological characteristics of 947 singleton placentas from infants born between 23 and 27 weeks gestation.
Stability of the effective potential of the gauge-less top-Higgs model in curved spacetime
Creators: name: Czerwińska, Olga
name: Lalak, Zygmunt
name: Nakonieczny, Łukasz
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We investigate stability of the Higgs effective potential in curved spacetime. To this end, we consider the gauge-less top-Higgs sector with an additional scalar field. Explicit form of the terms proportional to the squares of the Ricci scalar, the Ricci tensor and the Riemann tensor that arise at the one-loop level in the effective action has been determined. We have investigated the influence of these terms on the stability of the scalar effective potential. The result depends on background geometry. In general, the potential becomes modified both in the region of the electroweak minimum and in the region of large field strength.
description: 32 pages, 13 figures; version accepted for publication in JHEP
Supplementary methods and results - species specific impacts of suspended sediments on gill structure and function in coral reef fishes
Creators: name: Hess, Sybille
name: Leteisha Prescott
name: Hoey, Andrew S.
name: McMahon, Shannon
name: Wenger, Amelia S.
name: Rummer, Jodie L.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Science
subject: Ecology

description: This file contains supplementary information on larval rearing conditions, the experimental set-up for sediment resuspension, respirometry protocol, gill analysis, and additional results.
Phase Diagram of a Strongly Interacting Spin-Imbalanced Fermi Gas
Creators: name: Olsen, Ben A.
name: Revelle, Melissa C.
name: Fry, Jacob A.
name: Sheehy, Daniel E.
name: Hulet, Randall G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We obtain the phase diagram of spin-imbalanced interacting Fermi gases from measurements of density profiles of $^6$Li atoms in a harmonic trap. These results agree with, and extend, previous experimental measurements. Measurements of the critical polarization at which the balanced superfluid core vanishes generally agree with previous experimental results and with quantum Monte Carlo (QMC) calculations in the BCS and unitary regimes. We disagree with the QMC results in the BEC regime, however, where the measured critical polarizations are greater than theoretically predicted. We also measure the equation of state in the crossover regime for a gas with equal numbers of the two fermion spin states.
description: 7 pages, 5 figures
title: Pulmonary aspergillosis: different aspects and tips
Creators: name: El Ouazzani, Lamiaa
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Lung
subject: Conventional radiography
subject: CT
subject: Diagnostic procedure
subject: Pathology

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Objective: Demonstrate the value of imaging in the positive diagnosis and follow-up of pulmonary aspergillosis. Know how to differentiate the different types of pulmonary aspergillosis. To look for secondary localizations of the...
Tigecycline therapy for carbapenem-resistant Klebsiella pneumoniae (CRKP) bacteriuria leads to tigecycline resistance
Creators: name: Cober, E. D.
name: Cline, M.
name: Salata, R. A.
name: Kaye, K. S.
name: Richter, S. S.
name: Bonomo, R. A.
name: Kalayjian, R. C.
name: Evans, S. R.
name: Fowler, V. G.
name: van Duin, D.
name: Perez, F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is an increasing global threat. Here, we describe the prevalence and impact of tigecycline use in a cohort of patients with CRKP bacteriuria nested within a multicenter, prospective study. In the 21 month study period, 260 unique patients were included. Tigecycline was given to 80 (31%) patients. The use of tigecycline during the index hospitalization was significantly associated with the subsequent development of tigecycline resistance in the same patient (OR 6.13, 95%CI 1.15–48.65, p=0.03). In conclusion, the use of tigecycline with CRKP bacteriuria is common, and is associated with the subsequent development of tigecycline resistance.
Dual simulation of the 2-dimensional lattice U(1) gauge-Higgs model with a topological term
Creators: name: Gattringer, Christof
name: Kloiber, Thomas
name: Müller-Preussker, Michael
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: The 2-dimensional U(1) gauge-Higgs model with a topological term is a simple example of a lattice field theory where the complex action problem comes from the topological term. We show that the model can be exactly rewritten in terms of dual variables, such that the dual partition sum has only real and positive contributions. Using suitable algorithms the dual formulation allows for Monte Carlo simulations at arbitrary values of the vacuum angle. We demonstrate the feasibility of the dual simulation and study the continuum limit, as well as the phase diagram of the system.
description: 15 pages, 12 figures; comments and references added; final version to appear in Phys. Rev. D
title: Deep learning-based characterization of COVID-19-related lung parenchyma disease and risk of invasive mechanical ventilation in a Chilean University Hospital
Creators: name: Sotomayor, Camilo G.
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Lung
subject: CT
subject: Computer Applications-General
subject: Outcomes analysis
subject: Infection

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Computed tomography-based quantification of overall lung parenchyma disease (both ground glass opacities and consolidation) is relevant for initial assessment, follow-up and prognosis of COVID-19 patients. However, high-interobserver variability...
Supplementary Information from X-ray physico-chemical imaging during activation of cobalt-based Fischer–Tropsch synthesis catalysts.
Creators: name: Beale, Andrew M.
name: Jacques, Simon D. M.
name: Michiel, Marco Di
name: J. Frederick W. Mosselmans
name: Price, Stephen W. T.
name: Senecal, Pierre
name: Vamvakeros, Antonios
name: Paterson, James
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 30199 Analytical Chemistry not elsewhere classified
subject: 30399 Macromolecular and Materials Chemistry not elsewhere classified
subject: 30699 Physical Chemistry not elsewhere classified
subject: 100799 Nanotechnology not elsewhere classified
subject: FOS: Nanotechnology

description: Additional reference spectra and 2D images
(400941) Thomas Park
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Bacterial Contamination of Blood Components
Creators: name: Hay, Shauna N.
name: Brecher, Mark E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Blood for transfusion is a potential source of infection by a variety of known and unknown transmissible agents. Over the last 20 years, astounding reductions in the risk of viral infection via allogeneic blood have been achieved. As a result of this success, bacterial contamination of blood products has emerged as the greatest residual source of transfusion-transmitted disease. This paper summarizes the current status of detection, prevention, and elimination of bacteria in blood products for transfusion.
Basic Concepts of Microarrays and Potential Applications in Clinical Microbiology
Creators: name: Tang, Yi Wei
name: Miller, Melissa B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Summary: The introduction of in vitro nucleic acid amplification techniques, led by real-time PCR, into the clinical microbiology laboratory has transformed the laboratory detection of viruses and select bacterial pathogens. However, the progression of the molecular diagnostic revolution currently relies on the ability to efficiently and accurately offer multiplex detection and characterization for a variety of infectious disease pathogens. Microarray analysis has the capability to offer robust multiplex detection but has just started to enter the diagnostic microbiology laboratory. Multiple microarray platforms exist, including printed double-stranded DNA and oligonucleotide arrays, in situ-synthesized arrays, high-density bead arrays, electronic microarrays, and suspension bead arrays. One aim of this paper is to review microarray technology, highlighting technical differences between them and each platform's advantages and disadvantages. Although the use of microarrays to generate gene expression data has become routine, applications pertinent to clinical microbiology continue to rapidly expand. This review highlights uses of microarray technology that impact diagnostic microbiology, including the detection and identification of pathogens, determination of antimicrobial resistance, epidemiological strain typing, and analysis of microbial infections using host genomic expression and polymorphism profiles.
(400942) Jessie Park
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(400943) William Park
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The Brownian web, the Brownian net, and their universality
Creators: name: Schertzer, Emmanuel
name: Sun, Rongfeng
name: Swart, Jan M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60K35, 82C21

description: The Brownian web is a collection of one-dimensional coalescing Brownian motions starting from everywhere in space and time, and the Brownian net is a generalization that also allows branching. They appear in the diffusive scaling limits of many one-dimensional interacting particle systems with branching and coalescence. This article gives an introduction to the Brownian web and net, and how they arise in the scaling limits of various one-dimensional models, focusing mainly on coalescing random walks and random walks in i.i.d. space-time random environments. We will also briefly survey models and results connected to the Brownian web and net, including alternative topologies, population genetic models, true self-repelling motion, planar aggregation, drainage networks, oriented percolation, black noise and critical percolation. Some open questions are discussed at the end.
description: Based on a course given in the IHP trimestre program "Disordered Systems, Random Spatial Processes and Some Applications" (Jan 5-Apr 3, 2015)
Using Epstein-Barr Viral Load Assays To Diagnose, Monitor, and Prevent Posttransplant Lymphoproliferative Disorder
Creators: name: Gulley, Margaret L.
name: Tang, Weihua
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Summary: Epstein-Barr virus (EBV) DNA measurement is being incorporated into routine medical practice to help diagnose, monitor, and predict posttransplant lymphoproliferative disorder (PTLD) in immunocompromised graft recipients. PTLD is an aggressive neoplasm that almost always harbors EBV DNA within the neoplastic lymphocytes, and it is often fatal if not recognized and treated promptly. Validated protocols, commercial reagents, and automated instruments facilitate implementation of EBV load assays by real-time PCR. When applied to either whole blood or plasma, EBV DNA levels reflect clinical status with respect to EBV-related neoplasia. While many healthy transplant recipients have low viral loads, high EBV loads are strongly associated with current or impending PTLD. Complementary laboratory assays as well as histopathologic examination of lesional tissue help in interpreting modest elevations in viral load. Circulating EBV levels in serial samples reflect changes in tumor burden and represent an effective, noninvasive tool for monitoring the efficacy of therapy. In high-risk patients, serial testing permits early clinical intervention to prevent progression toward frank PTLD. Restoring T cell immunity against EBV is a major strategy for overcoming PTLD, and novel EBV-directed therapies are being explored to thwart virus-driven neoplasia.
THE PHENOMENON OF EPONYMY IN THE LINGUISTIC SYSTEM OF THE UZBEK LANGUAGE
Creators: name: Azimova, Anisa
Publisher: name: Zenodo
Year: 2023

description: This article provides detailed information about reforms in the field of culture, art, music, theater art in the Republic of Uzbekistan, the history of theater art, the development of theater art, and the issues of creating a modern hero in theater art.
title: Diagnosis of tumor invasion in hilar to lower bile duct cancer: Usefulness of diffusion-weighted imaging for differentiating other causes of bile duct wall thickening
Creators: name: Kurokawa, Hiroaki
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Biliary Tract / Gallbladder
subject: MR-Diffusion/Perfusion
subject: Imaging sequences
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Tumors derived from the common and hilar bile ducts are visualized as bile duct wall thickening and mass formation on computed tomography (CT) and magnetic resonance imaging (MRI)[1,2,3,4,5]. However, it is difficult to distinguish between malignant...
title: Role of MRI in various appearances of Multiple sclerosis and Tumefactive demyelination- a diagnostic conundrum.
Creators: name: Hafeez, Nidhin
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: CNS
subject: Neuroradiology brain
subject: MR
subject: MR-Diffusion/Perfusion
subject: MR-Spectroscopy
subject: Diagnostic procedure
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Role of MRI in rare type of multiple sclerosis - Tumefactive demyelination(TMD) mimicker of glioma, glioblastoma multiforme, lymphoma thus making accurate differentiation important. We discuss various focal and diffuse appearances of TMD with...
Supplementary Information from X-ray physico-chemical imaging during activation of cobalt-based Fischer–Tropsch synthesis catalysts
Creators: name: Beale, Andrew M.
name: Jacques, Simon D. M.
name: Michiel, Marco Di
name: J. Frederick W. Mosselmans
name: Price, Stephen W. T.
name: Senecal, Pierre
name: Vamvakeros, Antonios
name: Paterson, James
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 30199 Analytical Chemistry not elsewhere classified
subject: 30399 Macromolecular and Materials Chemistry not elsewhere classified
subject: 30699 Physical Chemistry not elsewhere classified
subject: 100799 Nanotechnology not elsewhere classified
subject: FOS: Nanotechnology

description: Additional reference spectra and 2D images
Importance of Relating Efficacy Measures to Unbound Drug Concentrations for Anti-Infective Agents
Creators: name: Gonzalez, Daniel
name: Derendorf, Hartmut
name: Schmidt, Stephan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: For the optimization of dosing regimens of anti-infective agents, it is imperative to have a good understanding of pharmacokinetics (PK) and pharmacodynamics (PD). Whenever possible, drug efficacy needs to be related to unbound concentrations at the site of action. For anti-infective drugs, the infection site is typically located outside plasma, and a drug must diffuse through capillary membranes to reach its target. Disease- and drug-related factors can contribute to differential tissue distribution. As a result, the assumption that the plasma concentration of drugs represents a suitable surrogate of tissue concentrations may lead to erroneous conclusions. Quantifying drug exposure in tissues represents an opportunity to relate the pharmacologically active concentrations to an observed pharmacodynamic parameter, such as the MIC. Selection of an appropriate specimen to sample and the advantages and limitations of the available sampling techniques require careful consideration. Ultimately, the goal will be to assess the appropriateness of a drug and dosing regimen for a specific pathogen and infection.
Enhancing the BBC's news and sports coverage with an ontology-driven information architecture
Creators: name: Howard, James
name: Oliver, Silver
Publisher: name: Zenodo
Year: 2011
Subjects: subject: BBC
subject: Sport coverage
subject: Information Architecture
subject: https://iskouk.org/subjects/PRUIHEDJ
subject: https://iskouk.org/subjects/W3ENEJYW
subject: https://iskouk.org/subjects/P5UQOBEY

description: In Tim Berners Lee’s original proposal for the Web (retrieved from http://info.cern.ch/Proposal.html) he gave us the basic ingredients to build the web of documents as we experience it today. Due to its simplicity, the Web became a victim of its own success as we were soon overwhelmed. At this point information architects were employed to group together documents into manageable piles using a variety of techniques to group sets of documents. The problem with this approach is that if we start out focusing on documents, our sites turn out document-centric and this is not how users think about the world. People are interested in things not documents. This leads us to move away from a document-orientated approach to Web development to a thing-focused one, and with this move comes the need for new tools and approaches to information architecture. This includes the use of domain-driven design to understand the things and relationships in a problem space and the use of open linked data sources to populate these models. This will be illustrated with case studies from the BBC’s Wildlife Finder and the World Cup project.
 In summary, Semantic Web-like thinking changes the way we build Web sites. Firstly it focuses us on real-world things and the relationships between them, secondly it introduces a culture of building with open vocabularies to add context and links that create richer, more useful and more findable digital products..
Viruses and Human Cancers: a Long Road of Discovery of Molecular Paradigms
Creators: name: Pagano, Joseph S.
name: Khalili, Kamel
name: White, Martyn K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: About a fifth of all human cancers worldwide are caused by infectious agents. In 12% of cancers, seven different viruses have been causally linked to human oncogenesis: Epstein-Barr virus, hepatitis B virus, human papillomavirus, human T-cell lymphotropic virus, hepatitis C virus, Kaposi's sarcoma herpesvirus, and Merkel cell polyomavirus. Here, we review the many molecular mechanisms of oncogenesis that have been discovered over the decades of study of these viruses. We discuss how viruses can act at different stages in the complex multistep process of carcinogenesis. Early events include their involvement in mutagenic events associated with tumor initiation such as viral integration and insertional mutagenesis as well as viral promotion of DNA damage. Also involved in tumor progression is the dysregulation of cellular processes by viral proteins, and we describe how this has been investigated by studies in cell culture and in experimental animals and by molecular cellular approaches. Also important are the molecular mechanisms whereby viruses interact with the immune system and the immune evasion strategies that have evolved.
On the distribution of particle acceleration sites in plasmoid-dominated relativistic magnetic reconnection
Creators: name: Nalewajko, Krzysztof
name: Uzdensky, Dmitri A.
name: Cerutti, Benoît
name: Werner, Gregory R.
name: Begelman, Mitchell C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We investigate the distribution of particle acceleration sites, independently of the actual acceleration mechanism, during plasmoid-dominated, relativistic collisionless magnetic reconnection by analyzing the results of a particle-in-cell numerical simulation. The simulation is initiated with Harris-type current layers in pair plasma with no guide magnetic field, negligible radiative losses, no initial perturbation, and using periodic boundary conditions. We find that the plasmoids develop a robust internal structure, with colder dense cores and hotter outer shells, that is recovered after each plasmoid merger on a dynamical time scale. We use spacetime diagrams of the reconnection layers to probe the evolution of plasmoids, and in this context we investigate the individual particle histories for a representative sample of energetic electrons. We distinguish three classes of particle acceleration sites associated with (1) magnetic X-points, (2) regions between merging plasmoids, and (3) the trailing edges of accelerating plasmoids. We evaluate the contribution of each class of acceleration sites to the final energy distribution of energetic electrons -- magnetic X-points dominate at moderate energies, and the regions between merging plasmoids dominate at higher energies. We also identify the dominant acceleration scenarios, in order of decreasing importance -- (1) single acceleration between merging plasmoids, (2) single acceleration at a magnetic X-point, and (3) acceleration at a magnetic X-point followed by acceleration in a plasmoid. Particle acceleration is absent only in the vicinity of stationary plasmoids. The effect of magnetic mirrors due to plasmoid contraction does not appear to be significant in relativistic reconnection.
description: 14 pages, 6 figures, 2 tables, accepted in ApJ
(400944) Mary Park
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Supplementary NMR HSQC titiration figures 1 to 6 from Heparin-bound chemokine CXCL8 monomer and dimer are impaired for CXCR1 and CXCR2 activation: implications for gradients and neutrophil trafficking.
Creators: name: Joseph, Prem Raj B.
name: Sawant, Kirti V.
name: Rajarathnam, Krishna
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Biophysics
subject: Immunology
subject: FOS: Clinical medicine
subject: Structural Biology

description: CXCR1 or CXCR2 receptor N-domain binding to heparin-bound CXCL8, and heparin binding to CXCR1 or CXCR2 receptor N-domain-bound CXCL8
title: Operator learning curve for transradial liver cancer embolization: implications for the initiation of a transradial access program
Creators: name: Tanzilli, Alessandro
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Arteries / Aorta
subject: Interventional vascular
subject: Liver
subject: Catheter arteriography
subject: Chemoembolisation
subject: Embolisation
subject: Technical aspects
subject: Neoplasia

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Transradial artery access (TRA) is considered an alternative to transfemoral artery access (TFA) for cardiac [1] and noncardiac vascular procedures with similar results. Many studies underline that TRA has several advantages over TFA such as minimal...
Association of carotid intima-media thickness with cardiovascular risk factors and patient outcomes in advanced chronic kidney disease: the RRI-CKD study
Creators: name: Gillespie, Brenda W.
name: Saran, Rajiv
name: Kotanko, Peter
name: Padilla, Robin L.
name: Hinderliter, Alan
name: Finkelstein, Fredric
name: Rajagopalan, Sanjay
name: Levin, Nathan W.
name: Kiser, Margaret
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Background: Chronic kidney disease (CKD) is associated with accelerated atherosclerosis and an increased risk of adverse cardiovascular disease (CVD) outcomes. The relationships of intima-media thickness (IMT), a measure of subclinical atherosclerosis, with traditional and nontraditional risk factors and with adverse outcomes in CKD patients are not well-established. Methods: IMT, clinical characteristics, cardiovascular risk factors, and clinical outcomes were measured in 198 subjects from the Renal Research Institute (RRI) CKD study, a four-center prospective cohort of patients with estimated glomerular filtration rate (eGFR) ≤ 50 mL/min/1.73 m2 not requiring renal replacement therapy. Results: The patients averaged 61 ± 14 years of age; the mean eGFR was 29 ± 12 mL/min/1.73 m2. Maximum IMT was more closely associated with traditional cardiovascular risk factors, including age, diabetes, dyslipidemia, and systolic blood pressure, than with nontraditional risk factors or with eGFR. Higher values of maximum IMT were also independently associated with clinical CVD and with other markers of subclinical CVD. Maximum IMT ≥ 2.6 mm was predictive of the composite endpoint of CVD events and death (hazard ratio (HR): 5.47 (95% confidence interval (CI): 2.97 – 10.07, p < 0.0001)) but was not related to progression to end-stage renal disease (HR: 1.67 (95% CI: 0.74 – 3.76, p = 0.21)). Conclusion: In patients with advanced pre-dialysis CKD, higher maximum IMT was associated with traditional cardiovascular risk factors, CVD, and other markers of subclinical CVD and was an independent predictor of cardiovascular events and death. Additional research is needed to examine the clinical utility of IMT in the risk stratification and clinical management of patients with CKD.
Dipole Modulation of Cosmic Microwave Background Temperature and Polarization
Creators: name: Ghosh, Shamik
name: Kothari, Rahul
name: Jain, Pankaj
name: Rath, Pranati K.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We propose a dipole modulation model for the Cosmic Microwave Background Radiation (CMBR) polarization field. We show that the model leads to correlations between l and l+1 multipoles, exactly as in the case of temperature. We obtain results for the case of TE, EE and BB correlations. An anisotropic or inhomogeneous model of primordial power spectrum which leads to such correlations in temperature field also predicts similar correlations in CMBR polarization. We analyze the CMBR temperature and polarization data in order to extract the signal of these correlation between l and l+1 multipoles. Our results for the case of temperature using the latest PLANCK data agree with those obtained by an earlier analysis. A detailed study of the correlation in the polarization data is not possible at present. Hence we restrict ourselves to a preliminary investigation in this case.
description: 25 pages, 5 figures, major changes
(400939) Robert Park
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Phenotypic heterogeneity in females with X-linked Alport syndrome
Creators: name: Allred, Samuel C.
name: Weck, Karen E.
name: Gasim, Adil
name: Mottl, Amy K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Aims: X-linked Alport syndrome (AS) is a monogenic inherited disorder of type IV collagen, a structural protein in the kidney and cochlea. Males typically exhibit a severe phenotype with end-stage renal disease (ESRD) and/or deafness by early adulthood. Because of the presence of two X chromosomes, females often have a less severe phenotype and hence the diagnosis of AS is often not considered. Herein, we present a case of an adolescent girl with proteinuria and hematuria in the setting of a strong family history of AL. Case report: The mother and maternal aunt of the proband had both presented with dipstick positive hematuria and proteinuria at age 8 years. These girls were not evaluated by nephrology until mid-adolescence when they had worsening creatinine levels. Kidney biopsy in the younger sister demonstrated segmental glomerulosclerosis with segmental thinning and lamination of the glomerular basement membrane, consistent with AS. Kidney biopsy in the older sister was performed just prior to the need for renal replacement therapy and showed only global glomerulosclerosis. Both sisters were transplanted by the age of 20 years. Their mother subsequently developed ESRD at age 53 years. With the advent of genetic testing, the proband and her family were brought in for evaluation. It had been assumed this family of AS had autosomal dominant transmission, however, genetic testing of the proband was positive for a splice site mutation of COL4A5 located on the X-chromosome. Sequencing of genes COL4A3, COL4A4, and COL4A6 were negative for mutation. Conclusions: The current case report demonstrates the importance of considering skewed X-inactivation in females who exhibit signs or symptoms of X-linked disorders.
title: Imaging Spectrum of intracranial meningiomas: Typical and atypical presentations
Creators: name: Hkaiem, Amir
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: CNS
subject: Neuroradiology brain
subject: CT
subject: MR
subject: Education
subject: Education and training
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Explain and illustrate the typical and atypical presentations of meningiomas with histopathological correlation. Highlight the atypical radiologic features ( CT and MRI ) of meningiomas and elucidate their potential...
Modeling sympathetic cooling of molecules by ultracold atoms
Creators: name: Lim, Jongseok
name: Frye, Matthew D.
name: Hutson, Jeremy M.
name: Tarbutt, M. R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We model sympathetic cooling of ground-state CaF molecules by ultracold Li and Rb atoms. The molecules are moving in a microwave trap, while the atoms are trapped magnetically. We calculate the differential elastic cross sections for CaF-Li and CaF-Rb collisions, using model Lennard-Jones potentials adjusted to give typical values for the s-wave scattering length. Together with trajectory calculations, these differential cross sections are used to simulate the cooling of the molecules, the heating of the atoms, and the loss of atoms from the trap. We show that a hard-sphere collision model based on an energy-dependent momentum transport cross section accurately predicts the molecule cooling rate but underestimates the rates of atom heating and loss. Our simulations suggest that Rb is a more effective coolant than Li for ground-state molecules, and that the cooling dynamics are less sensitive to the exact value of the s-wave scattering length when Rb is used. Using realistic experimental parameters, we find that molecules can be sympathetically cooled to 100$μ$K in about 10s. By applying evaporative cooling to the atoms, the cooling rate can be increased and the final temperature of the molecules can be reduced to 1$μ$K within 30s.
description: 16 pages, 14 figures. Minor corrections picked up at proof stage
The endonasal approach for treatment of cerebral aneurysms: A critical review of the literature
Creators: name: Pittman, Amy L.
name: Germanwala, Anand V.
name: Heiferman, Daniel M.
name: Somasundaram, Aravind
name: Alvarado, Alexis J.
name: Zanation, Adam M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The last two decades of neurosurgery have seen flourishing use of the endonasal approach for the treatment of skull base tumors. Safe and effective resections of neoplasms requiring intracranial arterial dissection have been performed using this technique. Recently, there have been a growing number of case reports describing the use of the endonasal approach to surgically clip cerebral aneurysms. We review the use of these approaches in intracranial aneurysm clipping and analyze its advantages, limitations, and consider future directions. Three major electronic databases were queried using relevant search terms. Pertinent case studies of unruptured and ruptured aneurysms were considered. Data from included studies were analyzed. 8 case studies describing 9 aneurysms (4 ruptured and 5 unruptured) treated by the endonasal approach met inclusion criteria. All studies note the ability to gain proximal and distal control and successful aneurysm obliteration was obtained for 8 of 9 aneurysms. 1 intraoperative rupture occurred and was controlled, and delayed complications of cerebrospinal fluid leak, vasospasm, and hydrocephalus occurred in 1, 1, and 2 patients, respectively. Described limitations of this technique include aneurysm orientation and location, the need for lower profile technology, and challenges with handling intraoperative rupture. The endonasal approach for clipping of intracranial aneurysms can be an effective approach in only very select cases as demonstrated clinically and through cadaveric exploration. Further investigation with lower profile clip technology and additional studies need to be performed. Options of alternative therapy, limitations of this approach, and team experience must first be considered.