cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Multi-Frequency Monitoring of the Seyfert 1 Galaxy NGC~4593 II: a Small, Compact Nucleus ?
Creators: name: Santos-Lleo, M.
name: Clavel, J.
name: Barr, P.
name: Glass, I. S.
name: Pelat, D.
name: Peterson, B. M.
name: Reichert, G.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We discuss the results of a campaign to monitor spectral variations in the low-luminosity Seyfert~1 galaxy NGC~4593, at X-rays, ultraviolet, optical and near IR frequencies. The observations and data analysis have been described in a companion paper (Santos-Lleó et al. 1994; Paper~1). The active nucleus in this galaxy is strongly and rapidly variable in all wavebands, implying that the continuum source is unusually compact. Its energy distribution from 1.2~$μ$m to 1200~Å\/ obeys a power-law whose index is significantly steeper than is usual in Seyfert's or QSO's; the ``big bump'' is either absent or shifted to wavelengths shorter than 1200~Å\/. The variations of the soft-X~ray {\em excess\/} do not correlate with those of the UV or hard X-ray continuum. The far UV and optical fluxes are well correlated, while the correlation between the hard X-rays and 1447 Å continuum is only marginally significant. Moreover, the optical flux cannot lag behind the UV by more than 6 days. These results cannot be accommodated in the framework of the standard geometrically thin accretion disk model. Rather, they suggest that the bulk of the UV and optical flux originates from thermal reprocessing of X-rays irradiating the disk. The soft X-ray excess is probably the only spectral component which originates from viscous dissipation inside the disk and the near infrared is probably emitted by hot dust heated by the UV radiation. Such a model is consistent with NGC~4593 having a relatively small black-hole mass of the order of $2\times10^{6}{\rm M_{\odot}}$ as inferred from the line variability study. The high ionization/excitation emission lines are very broad and strongly variable and their variations correlate with those of the continuum. The low excitation lines are significantly narrower and remain constant within the accuracy of our measurements. These results suggest a stratified BLR, where the degree of ionization and the velocity dispersion of the gas increase toward small radii. The \lya\ line responds to the variations of the continuum with a delay $\leq 4$ days. To a first order approximation, the BLR in NGC~4593 is well modelled with two different zones at distances of $\sim$~15 and 3 lt-ds from the ionizing source respectively.
description: 36 pages, postscript, compressed. tables included; Figures available upon request. MNRAS in press.
Reminiscences of Stephen C. Shadegg, 1967
Publisher: name: Columbia University
Year: 2020
Subjects: Public relations consultants
Presidents--Election--1952.--United States
Presidents--Election--1960.--United States
Presidents--Election--1964.--United States

description: Campaigns of Dwight Eisenhower, Richard Nixon, Barry Goldwater; Charles Percy Committee
Eprinomectin nanoemulgel for transdermal delivery against endoparasites and ectoparasites: preparation, in vitro and in vivo evaluation
Creators: name: Mao, Yujuan
name: Chen, Xiaolan
name: Xu, Bohui
name: Shen, Yan
name: Ye, Zixuan
name: Chaurasiya, Birendra
name: Liu, Li
name: Li, Yi
name: Xing, Xiaoling
name: Chen, Daquan
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Nanoemulgels are composed of O/W nanoemulsion and hydrogels and are considered as ideal carriers for the transdermal drug delivery because these have high affinity to load hydrophobic drugs. The stable formulation of eprinomectin (EPR) is very challenging because of it is high hydrophobic nature. In this work, we have prepared EPR loaded nanoemulgel for the treatment of endo- and ectoparasites. The surface morphology of optimized formulations was characterized by scanning electron microscopy. Additionally, skin permeability and irritation tests were conducted for in vitro safety and in vivo skin retention and pearmeation test of EPR nanoemulgel were conducted for efficacy study. Obtained results indicated that the optimized formulation had good shear-thinning behavior, bioadhesiveness properties, and are nanosized droplets with porous internal structure, which are required for topical application. Furthermore, this formulation has showed good skin permeability in comparison to suspension and has no skin irritating property. Overall, the obtained results proved that nanoemulgel is a promising carrier for transdermal drug delivery and EPR nanoemulgel is a promising formulation for the treatment of endo- and ectoparasites.
Cascading effects in bioprocessing: the impact of cell culture environment on CHO cell behaviour and host cell protein species
Creators: name: Goey, Cher Hui
Publisher: name: Imperial College London
Year: 2016

description: One of the reasons for the rejection of new drugs during clinical trials is the presence of host cell proteins (HCPs) in the drug formulation. HCPs are immunogenic impurities that can compromise patient safety. Moreover, proteolytic and binding HCPs compromise the integrity, and, hence, the stability and efficacy of a recombinant protein. Therefore, HCPs should be removed from the bioprocess train as soon as possible. Current downstream purification platforms are challenged by HCP-mAb co-elution. A Quality by Design strategy to overcome this problem is to reduce the number of HCPs in the downstream feedstock by tracing their source back to upstream culture and eliminating it. Previous studies have shown that upstream cell culture parameters, e.g. harvest time and culture temperature, significantly affect HCP profiles. However, little is known about how host cells coordinate and regulate their molecular machinery under different cell culture environment that results in different HCP profiles. This study presents experimental results linking cell culture temperature and key process indicators of CHO cell cultures and post-Protein A purification (mAb titre, HCP level and HCP species) by considering the cellular behaviour in terms of cell growth, cell cycle distribution and cell health). This study involved the application of single-use fed-batch bioreactors to culture IgG4 producing GS-CHO cell line, cell health and cell cycle analysis with NucleoCounter, Protein A purification and proteomic analysis with HCP ELISA kits and LC-MS/MS. Cells were more robust under mild hypothermia: over 90% of cells were maintained in a healthy state until the decline phase, and the onset of apoptosis was less evident compared to the results for physiological temperature. IgG4 titre and HCP level at harvest were comparable between the two cases. However, mild hypothermia reduced the HCP variety in HCCF by 36%, including 44% and 27% lower proteases and chaperones, respectively. The differences in HCP variety at harvest resulted in a significantly different HCP profile post-Protein A purification between the two cases. Half of the critically immunogenic HCPs species as determined by the CHOPPI tool were different between the two cases. This study shows that cell culture conditions significantly affect the HCP profile at harvest and that of purified samples.
Reminiscences of Stephen A. Mitchell 1967
Publisher: name: Columbia University
Year: 2019
Subjects: Politicians
Lawyers
Presidents--Election--1952.--United States
Presidents--Election--1956.--United States
Presidents--Election--1960.--United States

description: Family background; education; law practice in Chicago; activities in Democratic Party; World War II; Stevenson campaign, 1948; Stevenson's attitude towards politics; Ellen Borden Stevenson; pressures of public office; Chairman Democratic National Committee, 1952-55; 1952 campaign: Harry Truman, party unity; 1956 campaign: civil rights plank, the Kennedys; impressions of various political figures.
Nesting and brood-rearing opportunities for farmland birds in and around Miscanthus and short rotation coppice biomass crops
Creators: name: Pringle, Henrietta
Publisher: name: Imperial College London
Year: 2015

description: Reaching the EU target for renewable energy is likely to encourage a rapid expansion of biomass crop production in the UK. This expansion could pose a considerable threat to farmland birds, via the loss of suitable nesting habitat for ground-breeding birds or by decline in availability and accessibility of foraging resource for other farmland birds. Alternatively, the low-input management of biomass crops may provide benefits over more intensively managed arable crops. The potential impacts of biomass expansion on nesting and foraging opportunities were therefore investigated by examining the nesting success of lapwings (Vanellus vanellus) in Miscanthus, and the faecal components of songbirds nesting in boundaries of Miscanthus and short rotation coppice (SRC) willow fields. Despite similar nest densities and field occupancy across crop types, lapwing clutches experienced lower hatching success in Miscanthus fields than in arable crops. This result was mainly influenced by increased losses in 2012; a particularly wet breeding season. In years of already unfavourable breeding conditions, nests in Miscanthus may therefore be more vulnerable and suffer higher predation rates than those in arable crops. More invertebrates were found in SRC crop than in Miscanthus, and this was reflected in the faeces of whitethroat (Sylvia communis) chicks nesting in the boundaries of SRC and Miscanthus fields. Despite lower availability of Coleoptera in Miscanthus fields than SRC, this was not reflected in faeces of whitethroats or yellowhammers (Emberiza citronella), suggesting birds nesting in Miscanthus may supplement chick diet with food found elsewhere. Converting land to biomass crop cultivation may pose some risk to farmland birds, but while nesting and foraging opportunities may be limited in Miscanthus crop, SRC provides a more abundant foraging resource. The extent of any risk will depend on the crops being replaced, the position of biomass crops within the landscape and the extent of biomass crop uptake throughout the UK. It is vital that government energy targets are met in a sustainable manner, which could be achieved if the expansion of the industry is managed sensitively.
title: Computer Networks - Laboratory Exercises
title: Εργαστηριακές ασκήσεις δικτύων Η/Υ
Creators: name: Cheilas, Konstantinos
name: Vakaloudis, Alexandros
name: Politis, Anastasios
Publisher: name: Kallipos, Open Academic Editions
Year: 2016
Subjects: ΔΙΚΤΥΑ ΥΠΟΛΟΓΙΣΤΩΝ
ΑΝΑΛΥΣΗ ΠΡΩΤΟΚΟΛΛΩΝ
ΠΡΟΣΟΜΟΙΩΣΗ ΔΙΚΤΥΩΝ
ΕΛΕΓΧΟΣ ΛΕΙΤΟΥΡΓΙΑΣ
ΕΛΕΓΧΟΣ ΛΕΙΤΟΥΡΓΙΑΣ ΔΙΚΤΥΩΝ
ΑΠΟΣΦΑΛΜΑΤΩΣΗ ΔΙΚΤΥΩΝ
ΒΑΣΙΚΕΣ ΑΡΧΕΣ ΣΧΕΔΙΑΣΜΟΥ ΙΣΤΟΣΕΛΙΔΩΝ
ΑΣΦΑΛΕΙΑ ΔΙΚΤΥΩΝ
Computer Networks
Protocol Analysis
Network Simulation
Basic Troubleshooting Commands
Basic Web Design
HTML
Network Security
CSS

description: Το παρόν σύγγραμμα είναι ένας εργαστηριακός αυτός οδηγός απευθύνεται σε προπτυχιακούς φοιτητές Πληροφορικής ή συναφών αντικειμένων, που διδάσκονται κάποιο μάθημα Τεχνολογίας Δικτύων Η/Υ.

Περιλαμβάνει μια σειρά εργαστηριακών ασκήσεων με στόχο την εισαγωγή και εξοικείωση του φοιτητή με τις βασικές αρχές λειτουργίας των δικτύων. Είναι σχεδιασμένες με τέτοιον τρόπο ώστε να διαρκούν κατά μέσο όρο 2 (οι περισσότερες) ή 4 διδακτικές ώρες. Η ακριβής διάρκεια μπορεί να κυμανθεί ανάλογα με τη συζήτηση που θα γίνει εντός του εργαστηρίου. Επίσης, οι ασκήσεις είναι με τέτοιον τρόπο δομημένες ώστε να μπορούν να εκτελεστούν από τον φοιτητή χωρίς επίβλεψη και χωρίς άλλον εξοπλισμό.

Οι ασκήσεις καλύπτουν θέματα τόσο σε χαμηλά επίπεδα λειτουργίας (π.χ. ΙEEE 802.11b) όσο και σε υψηλότερα. Μερικά από τα αντικείμενα που καλύπτονται είναι:

Εντολές ελέγχου δικτύου. Τεχνικές αποσφαλμάτωσης.
Ανάλυση της δομής και των χαρακτηριστικών ενός δικτύου.
Η έννοια της ενθυλάκωσης των πακέτων και τις διαστρωμάτωσης των πρωτοκόλλων.
Στοιχεία λειτουργίας βασικών διαδικτυακών πρωτοκόλλων (IP, ICMP, TCP, FTP, HTTP)
Προσομοίωση δικτύων (με παραδείγματα από τη λειτουργία ασύρματων δικτύων).
Σενάρια ασφάλειας δικτύων (Firewalls, DMZ, Access Lists)
Βασική δομή της γλώσσας HTML.
Βασικά στοιχεία συγγραφής και μορφοποίησης ιστοσελίδων
Robinia pseudoacacia Linnaeus 1753
Creators: name: Jarvis, Charlie
Publisher: name: Linnaean Society of London in association with the Natural History Museum
Year: 2007
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Fabales
Fabaceae
Robinia
Robinia pseudoacacia

description: Robinia pseudoacacia Linnaeus, Species Plantarum 2: 722. 1753.
"Habitat in Virginia." RCN: 5449.
Replaced synonym of: Robinia acacia L. (1759), nom. illeg.
Lectotype (Barrie in Jarvis & al., Regnum Veg. 127: 82. 1993): Herb. Clifford: 354, Robinia 1, sheet B (BM-000646538).
Generitype of Robinia Linnaeus (vide Green, Prop. Brit. Bot.: 174. 1929).
Current name: Robinia pseudoacacia L. (Fabaceae: Faboideae).
Note: Polhill (in Bosser & al., Fl. Mascareignes 80: 80. 1990) indicated 913.1 (LINN) as type, but this sheet lacks the Species Plantarum number (i.e. “1”) and is a post-1753 addition to the herbarium, and not original material for the name. Brummitt & Taylor (in Taxon 39: 303. 1990) discussed the orthography of the specific epithet, concluding that “pseudoacacia” is correct.
description: Published as part of Jarvis, Charlie, 2007, Chapter 7: Linnaean Plant Names and their Types (part R), pp. 785-805 in Order out of Chaos. Linnaean Plant Types and their Types, London :Linnaean Society of London in association with the Natural History Museum on page 798, DOI: 10.5281/zenodo.291971
Annual modulation sensitivity in cold dark matter searches
Creators: name: Hasenbalg, F.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The sensitivity of experiments looking for annual modulated signals is discussed and analyzed. The choice of energy intervals for rate integration and enhancing the signal-to-noise ratio of the predicted WIMP signal is addressed. Special emphasis is placed on quantifying the minimum required exposure, MT, under experimental conditions. The difficulty reduces to establish the proper separation between the rate due to the unmodulated part of the WIMP signal and the rate of spurious background present in any experiment. The problem is solved by placing an upper bound to the unmodulated part of the signal using the best exclusion plot. We find that the lowest backgrounds achieved result in exposures in the range MT ~ 5 - 100 kg yr for masses m_χ > 100 GeV depending on the energy threshold of the detector. While our results are valid for Ge and NaI detectors, the formulae derived apply to other elements as well. Prescriptions are given to estimate exposures for higher background experiments.
description: Accepted in Astroparticle Phys., ReVTeX 7 pages, 6 Postscript figs
Self-Similar Evolution of Cosmological Density Fluctuations
Creators: name: Jain, Bhuvnesh
name: Bertschinger, Edmund
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The gravitational evolution of scale free initial spectra $P(k)\propto k^n$ in an Einstein-de Sitter universe is widely believed to be self-similar for $-3
description: 26 pages, uuencoded compressed postscript file, no figures. Submitted to ApJ
THREE-DIMENSIONAL HYDRODYNAMIC BONDI-HOYLE ACCRETION. IV. SPECIFIC HEAT RATIO 4/3.
Creators: name: Ruffert, M.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We investigate the hydrodynamics of three-dimensional classical Bondi-Hoyle accretion. A totally absorbing sphere of different sizes (1, 0.1 and 0.02 accretion radii) exerts gravity on and moves at different Mach numbers (0.6, 1.4, 3.0 and 10) relative to a homogeneous and slightly perturbed medium, which is taken to be an ideal gas ($γ=4/3$). We examine the influence of Mach number of the flow and size of the accretor upon the physical behaviour of the flow and the accretion rates. The hydrodynamics is modeled by the ``Piecewise Parabolic Method'' (PPM). The resolution in the vicinity of the accretor is increased by multiply nesting several $32^3$-zone grids around the sphere, each finer grid being a factor of two smaller in zone dimension than the next coarser grid. This allows us to include a coarse model for the surface of the accretor (vacuum sphere) on the finest grid while at the same time evolving the gas on the coarser grids. For small Mach numbers (0.6 and~1.4) the flow patterns tend towards a steady state, while in the case of supersonic flow (Mach~3 and~10) and small enough accretors, (radius of~0.1 and~0.02 accretion radii) an unstable Mach cone develops, destroying axisymmetry. Our 3D models do not show the highly dynamic flip-flop flow so prominent in 2D calculations performed by other authors. In the gamma=4/3 models, the shock front remains closer to the accretor and the mass accretion rates are higher than in the gamma=5/3 models, whereas the rms of the specific angular momentum accreted does not change.
description: uuencoded compressed postscript. 12 pages. includes some figures.
Investigating the impact of anaesthesia and surgery on Alzheimer's disease and the potential therapeutic role of Statin
Creators: name: Lloyd, Dafydd
Publisher: name: Imperial College London
Year: 2015

description: This study examines the impact of general anaesthesia, surgery and perioperative atorvastatin on Alzheimer's disease pathology in mice. A progressive neurodegenerative condition of complex aetiology, Alzheimer's is a common cause of dementia in humans but has no disease modifying treatment. Its long pre-symptomatic phase and lack of known biomarkers means asymptomatic individuals are exposed to modifiable risk factors in early life that influence disease progression and trajectory in the long term. Anaesthesia with surgery may be a modifiable risk factor. Neuroinflammation is a common feature of anaesthesia with surgery and Alzheimer's. Atorvastatin has potent anti-inflammatory pleiotropic effects that may be a useful perioperative intervention to modulate any acute on chronic neuroinflammatory interaction. The effects of the anaesthetic agents, isoflurane, nitrous oxide and xenon, were observed in immortal human cell lines that over-express APP and also in primary mouse hippocampal neurones incubated with amyloid beta. Altered distribution of APP, BACE-1 activity and differing expression of cleaved caspase-3 and BCL-2 were observed post exposure, with no change in gamma-secretase expression. The effects of anaesthesia, unilateral nephrectomy surgery and atorvastatin on pre-symptomatic and older APP23 mice (a murine model of Alzheimer's) were examined using behaviour techniques including Trace fear conditioning, Morris water maze and Y maze. Genotype dependent differences in learning were detected in different paradigms, as well as a post modifiable risk factor deficit in novel learning that was not seen after introduction of atorvastatin. Y maze performance showed changes in exploratory drive and working memory after the modifiable risk factor. Markers of neuroinflammation, synaptic function and amyloid beta pathology were quantified, showing a neuroinflammatory response and altered amyloid pathology, but no detectable change in synaptic marker after the modifiable risk factor. Anaesthesia with surgery does affect Alzheimer's neuropathology in mice, with perioperative atorvastatin changing both novel learning and working memory after anaesthesia with surgery.
Additional file 2 of Inhibition of GSDMD-mediated pyroptosis triggered by Trichinella spiralis intervention contributes to the alleviation of DSS-induced ulcerative colitis in mice
Creators: name: Ma, Zhen-Rong
name: Li, Zhuo-Lin
name: Zhang, Ni
name: Lu, Bin
name: Li, Xuan-Wu
name: Huang, Ye-Hong
name: Nouhoum, Dibo
name: Liu, Xian-Shu
name: Xiao, Ke-Chun
name: Cai, Li-Ting
name: Xu, Shao-Rui
name: Yang, Xue-Xian O.
name: Huang, Shuai-Qin
name: Wu, Xiang
Publisher: name: figshare
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer

description: Additional file 2: Table S1. Assessment of the disease activity index (DAI).
Assessing the Impacts of Large-Scale Water Transfer Projects on Communities: Lessons Learned from a Systematic Literature Review
Creators: name: Wang, Zelin
name: Nixon, Rebecca
name: Erwin, Anna
name: Ma, Zhao
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Space Science
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Large-scale water transfer projects (LWTPs) have been promoted to address rising water demands around the world. Scholars have been examining various impacts of LWTPs for decades; however, there is limited research that systematically examines the literature and synthesizes impacts and lessons learned from LWTPs. By conducting a systematic literature review, we assess the impacts of LWTP implementation on communities followed by the social, political, and economic factors that shape the implementation of LWTPs. Our review indicates that LWTPs can threaten livelihood strategies, jeopardize the sustainability of traditional cultures, and disrupt communities through resettlement. These impacts are shaped by the use of water as a political mechanism, the prioritization of economic interests, and unequal participation of stakeholders. Our review goes beyond individual studies of LWTPs to highlight the importance of using an environmental justice framework to guide LWTP assessments so that these assessments can address unique contexts of individual LWTPs.
A Two-Dimensional Spectroscopic Study of Emission Line Galaxies in the Faint Infrared Grism Survey (FIGS) I: Detection Method and Catalog
Creators: name: Pirzkal, Norbert
name: Rothberg, Barry
name: Ryan, Russell E.
name: Malhotra, Sangeeta
name: Rhoads, James
name: Grogin, Norman
name: Curtis-Lake, Emma
name: Chevallard, Jacopo
name: Charlot, Stephane
name: Finkelstein, Steven L.
name: Koekemoer, Anton M.
name: Ghavamian, Parviz
name: Rodrigues, Myriam
name: Hammer, François
name: Puech, Mathieu
name: Larson, Rebecca L.
name: Christensen, Lise
name: Cimatti, Andrea
name: Ferreras, Ignacio
name: Gardner, Jonathan P.
name: Gronwall, Caryl
name: Hathi, Nimish P.
name: Joshi, Bhavin
name: Kuntschner, Harald
name: Meurer, Gerhardt R.
name: O'Connell, Robert W.
name: Oestlin, Goeran
name: Pasquali, Anna
name: Pharo, John
name: Straughn, Amber N.
name: Walsh, Jeremy R.
name: Watson, Darach
name: Windhorst, Rogier A.
name: Zakamsk, Nadia L
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present the results from the application of a two-dimensional emission line detection method, EMission-line two-Dimensional (EM2D), to the near-infrared G102 grism observations obtained with the Wide-Field Camera 3 (WFC3) as part of the Cycle 22 {\em Hubble Space Telescope} Treasury Program: the Faint Infrared Grism Survey (FIGS). Using the EM2D method, we have assembled a catalog of emission line galaxies (ELGs) with resolved star formation from each of the four FIGS fields. Not only can one better assess the global properties of ELGs, but the EM2D method allows for the analysis and an improved study of the individual emission-line region {\it within} each galaxy. This paper includes a description of the methodology, advantages, and the first results of the EM2D method applied to ELGs in FIGS. The advantage of 2D emission line measurements includes significant improvement of galaxy redshift measurements, approaching the level of accuracy seen in high-spectral-resolution data, but with greater efficiency; and the ability to identify and measure the properties of multiple sites of star-formation and over scales of $\sim$ 1 kpc within individual galaxies out to z $\sim$ 4. The EM2D method also significantly improves the reliability of high-redshift ($z\sim7$) Lyman-$α$ detections. Coupled with the wide field of view and high efficiency of space-based grism observations, EM2D provides a noteworthy improvement on the physical parameters that can be extracted from grism observations.
description: Accepted by ApJ
Reminiscences of Stephen Reinhardt 1990
Publisher: name: Columbia University
Year: 2020
Subjects: Judges
Campaign management

description: Recollections of Allard K. Lowenstein: Yale Law School, Shirley Oakes Butler; involvement with California Democratic politics: California Democratic Council, Dump Johnson campaign, 1967, Robert F. Kennedy assassination conspiracy theory, Governor Jerry Brown, congressional campaign, 1974, presidential campaign, 1980
Caragana pygmaea
Creators: name: Jarvis, Charlie
Publisher: name: Linnaean Society of London in association with the Natural History Museum
Year: 2007
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Fabales
Fabaceae
Caragana
Caragana pygmaea

description: Robinia pygmaea Linnaeus, Species Plantarum 2: 723. 1753.
"Habitat in Sibiria." RCN: 5456.
Type not designated.
Original material: Gerber?, Herb. Linn. No. 913.7 (LINN); [icon] in Amman, Stirp. Rar. Ruth.: 204, t. 35. 1739.
Current name: Caragana pygmaea (L.) DC. (Fabaceae: Faboideae).
description: Published as part of Jarvis, Charlie, 2007, Chapter 7: Linnaean Plant Names and their Types (part R), pp. 785-805 in Order out of Chaos. Linnaean Plant Types and their Types, London :Linnaean Society of London in association with the Natural History Museum on page 798, DOI: 10.5281/zenodo.291971
title: Flight Dynamics and Control
title: A Linear Aproach of the Aircraft's Equations of Motion, Stability, Flying and Handling Qualities
titleType: AlternativeTitle
title: Δυναμική και έλεγχος πτήσης
title: Γραμμική Προσέγγιση των Εξισώσεων Κίνησης του Αεροσκάφους, Ευστάθεια, Χαρακτηριστικά Πτήσης και Ευκολίας Χειρισμού
titleType: AlternativeTitle
Creators: name: Antoniadis, Ioannis
Publisher: name: Kallipos, Open Academic Editions
Year: 2016
Subjects: ΔΥΝΑΜΙΚΗ ΠΤΗΣΗΣ
ΕΥΣΤΑΘΕΙΑ ΠΤΗΣΗΣ
ΕΛΕΓΧΟΣ ΠΤΗΣΗΣ
ΧΑΡΑΚΤΗΡΙΣΤΙΚΑ ΠΤΗΣΗΣ ΚΑΙ ΕΥΚΟΛΙΑΣ ΧΕΙΡΙΣΜΟΥ
Flying Dynamics And Control
Stability
Flying And Handling Qualities

description: Το βιβλιο απευθύνεται καταρχήν σε σπουδαστές των κύκλων Αεροναυπηγών Μηχανολόγων Μηχανικών των Πολυτεχνικών Σχολών της χώρας, καθώς και σε όλους εκείνους τους μηχανικούς, τεχνικούς ή/και ιπτάμενους, οι οποίοι ενδιαφέρονται να αποκτήσουν στέρεες επιστημονικές βάσεις στο αντικείμενο της Δυναμικής και Ελέγχου Πτήσης.

To βιβλίο αναφέρεται στον τρόπο με τον οποίο είναι δυνατό ένα αεροσκάφος να αποκτήσει ικανοποιητικά χαρακτηριστικά πτήσης και ευκολίας χειρισμού (flying and handling qualities). Για το λόγο αυτό ιδιαίτερη μνεία δίνεται στα δυναμικά χαρακτηριστικά και στα χαρακτηριστικά ευστάθειας και ελέγχου τα οποία αποτελούν και τη βάση για την ανωτέρω ανάλυση. Το βιβλίο πραγματεύεται τρία βασικά ερωτήματα:

1) Τη διαμόρφωση των χαρακτηριστικών ευστάθειας και ελέγχου του αεροσκάφους και πως αυτά επηρεάζουν τα χαρακτηριστικά πτήσης.
2) Τα αποδεκτά χαρακτηριστικά πτήσης, τον τρόπο που ορίζονται, ερμηνεύονται και εφαρμόζονται οι ανάλογες απαιτήσεις μέσω των κανονισμών και τον τρόπο που αυτές οι απαιτήσεις ορίζουν το φάκελο πτήσης.
3) Τον τρόπο που είναι δυνατό να βελτιωθούν τα μη αποδεκτά χαρακτηριστικά πτήσης.

Το βιβλίο αρχικά περιέχει τη θεωρία της δυναμικής συμπεριφοράς του αεροσκάφους. Αυτή περιλαμβάνει την ανάπτυξη και την επίλυση των πλήρων εξισώσεων κίνησης, την απλοποιημένη τους μορφή για διαμήκη και εγκάρσια δυναμική και τη μελέτη της απόκρισης του αεροσκάφους στα πηδάλια ελέγχου με τον καθορισμό των συναρτήσεων μεταφοράς.
Στη συνέχεια αναλύσεται ο τρόπος με τον οποίο ο πιλότος χειρίζεται το αεροσκάφος όσο ο τρόπος με τον οποίο ο άνθρωπος αντιλαμβάνεται την πτήση. Τέλος, αναλύονται οι βασικοί τρόποι ελέγχου με ανάδραση (“αυτόματοι πιλότοι”) καθώς και γενικότεροι τρόποι βελτιστοποίησης των χαρακτηριστικών πτήσης.
Το βιβλίο ειπλέον περιλιλαμβάνει εφαρμογές με δυναμικά δεδομένα μιας ποικιλίας αεροσκαφών, καθώς και μία σύντομη επισκόπηση των βασικών υποσυστημάτων του αεροσκάφους (οργανα,ελεγκτές,επενεργητές) που χρησιμοποιούνται για τον έλεγχο της πτήσης.
title: Biotechnology Biofuels
title: Βιοτεχνολογική παραγωγή βιοκαυσίμων
Creators: name: Christakopoulos, Paul
name: Topakas, Evangelos
Publisher: name: Kallipos, Open Academic Editions
Year: 2016
Subjects: ΒΙΟΤΕΧΝΟΛΟΓΙΑ
ΒΙΟΜΑΖΑ
ΒΙΟΚΑΤΑΛΥΣΗ
ΜΙΚΡΟΦΥΚΗ
ΠΕΡΙΒΑΛΛΟΝ
ΚΥΤΤΑΡΙΝΗ
ΠΡΟΚΑΤΕΡΓΑΣΙΑ ΒΙΟΜΑΖΑΣ
ΑΙΘΑΝΟΛΟΠΑΡΑΓΩΓΟΙ ΜΙΚΡΟΟΡΓΑΝΙΣΜΟΙ
ΒΙΟΚΑΥΣΙΜΑ ΔΕΥΤΕΡΗΣ ΓΕΝΙΑΣ
ΒΙΟΚΑΥΣΙΜΑ ΤΡΙΤΗΣ ΓΕΝΙΑΣ
ΠΑΡΑΓΩΓΗ ΒΙΟΜΑΖΑΣ ΜΙΚΡΟΦΥΚΩΝ
ΒΙΟΝΤΗΖΕΛ
ΔΙΕΡΓΑΣΙΕΣ ΠΑΡΑΓΩΓΗΣ
ΚΥΤΤΑΡΙΝΙΚΗ ΑΙΘΑΝΟΛΗ
Biotechnology
Biomass
Biocatalysis
Microalgae
Environment
Cellulose
Biomass Pretreatment
Ethanol Producing Microorganisms
Second Generation Biofuels
Third Generation Biofuels
Production Of Microalgae
Biodiesel
Production Process
Cellulosic Ethanol

description: Στην εποχή μας έννοιες όπως «βιοκαύσιμα», «βιομάζα», «βιοαιθανόλη», «βιοντήζελ», συχνά προκαλούν αμηχανία όχι μόνο στο ευρύτερο κοινό, αλλά πολλές φορές και στην ίδια την επιστημονική κοινότητα.
Έτσι, οι σημειώσεις αυτές και στα πλαίσια του μαθήματος «Βιοτεχνολογία και Περιβάλλον» αποτελούν μια πρώτη προσπάθεια να δώσουν στους φοιτητές μας τα εφόδια ώστε να χρησιμοποιούν τους όρους αυτούς όχι αφηρημένα αλλά ως εργαλεία της επιστήμης της Χημικής Μηχανικής που πάντα αναζητά να δώσει λύσεις φιλικές προς το περιβάλλον, προσαρμοζόμενη σε απαιτήσεις όχι μόνο επιστημονικές αλλά και ταυτόχρονα κοινωνικές.
Τέλος, ευχόμαστε ότι οι σημειώσεις αυτές θα αποτελέσουν το έναυσμα ώστε πολλοί από τους φοιτητές μας να αποτελέσουν τους πρωταγωνιστές της μεταστροφής της κοινωνίας μας για τη χρησιμοποίηση αειφόρων και ενεργειακά καθαρών πρακτικών.
Gravity with more or less gauging
Creators: name: Gielen, Steffen
name: Ardon, Rodrigo de Leon
name: Percacci, Roberto
Publisher: name: arXiv
Year: 2018
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: General Relativity is usually formulated as a theory with gauge invariance under the diffeomorphism group, but there is a 'dilaton' formulation where it is in addition invariant under Weyl transformations, and a 'unimodular' formulation where it is only invariant under the smaller group of special diffeomorphisms. Other formulations with the same number of gauge generators, but a different gauge algebra, also exist. These different formulations provide examples of what we call 'inessential gauge invariance', 'symmetry trading' and 'linking theories'; they are locally equivalent, but may differ when global properties of the solutions are considered. We discuss these notions in the Lagrangian and Hamiltonian formalism.
description: 24 pages, 1 table, 1 figure; minor changes to match published version
MOESM1 of Toll-Like Receptor 4 Engagement Inhibits Adenosine 5â ˛-Monophosphate-Activated Protein Kinase Activation through a High Mobility Group Box 1 Protein-Dependent Mechanism
Creators: name: Jean-Marc Tadie
name: Hong-Beom Bae
name: Deshane, Jessy
name: Bell, Celeste
name: Lazarowski, Eduardo
name: Chaplin, David
name: Thannickal, Victor
name: Abraham, Edward
name: Jaroslaw Zmijewski
Publisher: name: figshare
Year: 2012
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Supplementary material, approximately 549 KB.
Calogero-Sutherland Approach to Defect Blocks
Creators: name: Isachenkov, Mikhail
name: Liendo, Pedro
name: Linke, Yannick
name: Schomerus, Volker
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Extended objects such as line or surface operators, interfaces or boundaries play an important role in conformal field theory. Here we propose a systematic approach to the relevant conformal blocks which are argued to coincide with the wave functions of an integrable multi-particle Calogero-Sutherland problem. This generalizes a recent observation in 1602.01858 and makes extensive mathematical results from the modern theory of multi-variable hypergeometric functions available for studies of conformal defects. Applications range from several new relations with scalar four-point blocks to a Euclidean inversion formula for defect correlators.
description: v2: changes for clarity
Bosonization of Fermi liquids in a weak magnetic field
Creators: name: Barci, Daniel G.
name: Fradkin, Eduardo
name: Ribeiro, Leonardo
Publisher: name: arXiv
Year: 2018
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Novel controlled non-perturbative techniques are a must in the study of strongly correlated systems, especially near quantum criticality. One of these techniques, bosonization, has been extensively used to understand one-dimensional, as well as higher dimensional electronic systems at finite density. In this paper, we generalize the theory of two-dimensional bosonization of Fermi liquids, in the presence of a homogeneous weak magnetic field perpendicular to the plane. Here, we extend the formalism of bosonization to treat free spinless fermions at finite density in a uniform magnetic field. We show that particle-hole fluctuations of a Fermi surface satisfy a {\em covariant Schwinger algebra}, allowing to express a fermionic theory with forward scattering interactions as a quadratic bosonic theory representing the quantum fluctuations of the Fermi surface. By means of a coherent-state path integral formalism we compute the fermion propagator as well as particle-hole bosonic correlations functions. We analyze the presence of de Haas-van Alphen oscillations and show how the quantum oscillations of the orbital magnetization, the Lifshitz-Kosevich theory, are obtained by means of the bosonized theory. We also study the effects of forward scattering interactions. In particular, we obtain oscillatory corrections to the Landau zero sound collective mode.
description: 20 pages, 6 figures. Improved version. Two figures added. References updated. New section on forward scattering interactions added
Reminiscences of Stephen Sondheim, 1982
Publisher: name: Columbia University
Year: 2021
Subjects: Composers
Theater--Production and direction
Musicals
Composition (Music)
Musical criticism
Popular music--Writing and publishing

description: Family life, boarding school, Williams College; Westport Playhouse, apprenticeship; influence and friendship of Oscar Hammerstein; ALLEGRO; composing music for film: STAVISKY, directorial control; writing and production of SWEENEY TODD, SATURDAY NIGHT, WEST SIDE STORY, SHIELD; reflections on publicity, critics, audiences; work with Dramatists' Guild; songwriters; impressions of Lemuel Ayers, Harold Prince, Alain Resnais
The Declined Activity in the Nucleus of NGC 1316
Creators: name: Iyomoto, Naoko
name: Makishima, Kazuo
name: Tashiro, Makoto
name: Inoue, Susumu
name: Kaneda, Hidehiro
name: Matsumoto, Yukari
name: Mizuno, Tsunefumi
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: NGC 1316 (Fornax A) is a radio galaxy with prototypical double lobes, where the magnetic field intensity is accurately measured via the inverse-Compton technique. The radio-emitting electrons in the lobes are inferred to have a synchrotron life time of 0.1 Gyr. Considering the lobe energetics, we estimate the past nuclear X-ray luminosity of NGC 1316 to be at least 4 times 10^{34} W (4 times 10^{41} erg s^{-1}). Thus, the nucleus was rather active at least 0.1 Gyr ago. In contrast, we confirmed with ASCA and ROSAT that the nucleus of NGC 1316 is very faint in X-rays at present, with the 2--10 keV luminosity of any AGN-like hard component being < 2 times 10^{33} W (2 times 10^{40} erg s^{-1}) even assuming a nuclear obscuration up to 10^{28} m^{-2} (10^{24} cm^{-2}). This is at least an order of magnitude lower than the estimated past activity, indicating that the nucleus is presently very inactive. From these two results, we conclude that the nucleus of NGC 1316 has become dormant during the last 0.1 Gyr. This suggests the possible abundance of ``dormant'' quasars in nearby galaxies.
description: 7 pages, 2 figures, to be published in the Astrophysical Journal Letters
title: Εισαγωγή στον αντικειμενοστραφή προγραμματισμό με Python
title: Μια Προσέγγιση από την Πλευρά των Υπολογιστικών Συστημάτων
titleType: AlternativeTitle
Creators: name: Magoutis, Konstantinos
name: Nikolaou, Christos
Publisher: name: Kallipos, Open Academic Editions
Year: 2016
Subjects: ΠΡΟΓΡΑΜΜΑΤΙΣΜΟΣ ΥΠΟΛΟΓΙΣΤΩΝ
Computer Programming
Programming Languages

description: Ο σκοπός αυτού του συγγράμματος είναι να διδάξει σε προπτυχιακούς φοιτητές Μηχανικών Η/Υ, Επιστήμης Υπολογιστών και συναφών σχολών τις βασικές αρχές του προγραμματισμού λογισμικού με γλώσσες υψηλού επιπέδου, χρησιμοποιώντας τη γλώσσα Python. Το σύγγραμμα εισάγει τους φοιτητές στις αρχές του αντικειμενοστραφούς προγραμματισμού αλλά και σε θέματα πιο προχωρημένου επιπέδου, όπως ο προγραμματισμός συστημάτων με έμφαση σε τεχνικές συγχρονισμού πολλαπλών διεργασιών/νημάτων, τον δικτυακό προγραμματισμό και εισαγωγικά θέματα προγραμματισμού κατανεμημένων συστημάτων.

 Περιεχόμενα:
 Εισαγωγή στον προγραμματισμό
 Εισαγωγή στην Python
 Τιμές, τύποι, μεταβλητές, λέξεις-κλειδιά, εντολές
 Εκφράσεις, τελεστές, σχόλια
 Συναρτήσεις και εκτέλεση υπό συνθήκη
 Eπανάληψη με την εντολή while
 Συμβολοσειρές, λίστες, πλειάδες, λεξικά
 Αρχεία, εξαιρέσεις και εκσφαλμάτωση
 Κλάσεις και αντικείμενα
 Ταυτόχρονος προγραμματισμός και νήματα
 Δικτυακός προγραμματισμός
 Εισαγωγή στον προγραμματισμό κατανεμημένων συστημάτων λογισμικού
 Τεχνολογικές τάσεις και μελλοντικές εξελίξεις
title: ADCO, Cartulaire des Dominicains de Dijon (1286), Cart. 221 (H 53), 170 folios, f. 0071
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Cartulaire des Dominicains de Dijon (1286), Archives départementales de la Côte-d'Or, Cart. 221 (H 53), 170 folios. Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire des Dominicains de Dijon (1286), Archives départementales de la Côte-d'Or, Cart. 221 (H 53), 170 folios, f. 0071, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: Dijon
description: Provenance: http://www.wikidata.org/entity/Q7003
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb15250518p
description: Provenance: http://www.idref.fr/02643413X/id
description: Provenance: https://www.geonames.org/6453767
Additional file 3 of Inhibition of GSDMD-mediated pyroptosis triggered by Trichinella spiralis intervention contributes to the alleviation of DSS-induced ulcerative colitis in mice
Creators: name: Ma, Zhen-Rong
name: Li, Zhuo-Lin
name: Zhang, Ni
name: Lu, Bin
name: Li, Xuan-Wu
name: Huang, Ye-Hong
name: Nouhoum, Dibo
name: Liu, Xian-Shu
name: Xiao, Ke-Chun
name: Cai, Li-Ting
name: Xu, Shao-Rui
name: Yang, Xue-Xian O.
name: Huang, Shuai-Qin
name: Wu, Xiang
Publisher: name: figshare
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer

description: Additional file 3: Table S2. Primers used in the qRT-PCR experiment.
COALESCING NEUTRON STARS AS GAMMA RAY BURSTERS ?
Creators: name: Ruffert, M.
name: Janka, H. -Th.
name: Keil, W.
name: Schaefer, G.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We investigate the dynamics and evolution of coalescing neutron stars. The three-dimensional Newtonian equations of hydrodynamics are integrated by the `Piecewise Parabolic Method' However, we do include the effects of the emission of gravitational waves on the hydrodynamics. The properties of neutron star matter are described by the equation of state of Lattimer & Swesty. In addition to the fundamental hydrodynamic quantities, density, momentum, and energy, we follow the time evolution of the electron density in the stellar gas. Energy losses and changes of the electron abundance due to the emission of neutrinos are taken into account by an elaborate ``neutrino leakage scheme'', which employs a careful calculation of the lepton number and energy source terms of all neutrino types. The grid is Cartesian and equidistant with a resolution of 64**3 or 128**3, which allows us to calculate the self-gravity via fast Fourier transforms.
description: extended abstract contribution to the proceedings of the 17th Texas Symposium, 2 pages, uuencoded compressed postscript.
MOESM1 of Prime-Boost Vaccination with rBCG/rAd35 Enhances CD8+ Cytolytic T-Cell Responses in Lesions from Mycobacterium Tuberculosis-Infected Primates
Creators: name: Sayma Rahman
name: Magalhaes, Isabelle
name: Jubayer Rahman
name: Ahmed, Raija
name: Sizemore, Donata
name: Scanga, Charles
name: Weichold, Frank
name: Verreck, Frank
name: Ivanela Kondova
name: Sadoff, Jerry
name: Thorstensson, Rigmor
name: SpĂĽngberg, Mats
name: Svensson, Mattias
name: Andersson, Jan
name: Maeurer, Markus
name: Brighenti, Susanna
Publisher: name: figshare
Year: 2012
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Supplementary material, approximately 945 KB.
Recent Development and Validation of Omeprazole Analysis Methods in Capsules with Absorbance Methods and Areas under Curves Methods with UV-Vis Spectrophotometry
Creators: name: Harrizul Rivai
name: Rizqa Hasanah
name: Zikra Azizah
Publisher: name: Zenodo
Year: 2021
Subjects: Methods of absorbance
methods of area under the curve
omeprazole
UV-Vis spectrophotometry

description: To analyse omeprazole in capsules, two simple spectrophotometric methods have been developed. As a solvent in this method, sodium hydroxide 0.1 N is used. The absorbance method was used at 304.80 nm, and the under-curve area method was used at wavelengths ranging from 281.60 nm to 333.60 nm. Both methods were found to be linear over a concentration range of 10 g / mL - 18 g / mL. The correlation coefficient for the absorbance method is 0.9998, while the correlation coefficient for the area-under-curve method is 0.997. The absorbance method yielded 105.48% of generic omeprazole capsules, while the field under the curve method yielded 102.87%. The absorbance approach gives a percentage of omeprazole capsules of the trademark of 104.02%, while the field under the curve method yielded a percentage of 103.62%. The percentage of both samples that meet the criteria of Pharmacopoeia Indonesia version V, which is 90% to 110%, is 90% to 110%. For both approaches, the relative standard deviation is 2%. The absorbance approach and the region under the curve did not vary substantially (sig. 2-tailed> 0.05), according to statistical analysis. As a result, the absorbance method and UV-Vis spectrophotometry's region under the curve can be used to determine omeprazole levels in the formulation capsule.
Caragana spinosa Hornem.
Creators: name: Jarvis, Charlie
Publisher: name: Linnaean Society of London in association with the Natural History Museum
Year: 2007
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Fabales
Fabaceae
Caragana
Caragana spinosa

description: Robinia spinosa Linnaeus, Mantissa Plantarum Altera: 269. 1771.
"Habitat in Sibiriae montibus arenosis siccissimis Salengiae et Kiaechae." RCN: 5454.
Type not designated.
Original material: none traced.
Current name: Caragana spinosa (L.) Hornem. (Fabaceae: Faboideae).
description: Published as part of Jarvis, Charlie, 2007, Chapter 7: Linnaean Plant Names and their Types (part R), pp. 785-805 in Order out of Chaos. Linnaean Plant Types and their Types, London :Linnaean Society of London in association with the Natural History Museum on page 798, DOI: 10.5281/zenodo.291971
Spatio-temporal mapping of protein activity in live zebrafish using FRET FLIM OPT
Creators: name: Andrews, Natalie Julia
Publisher: name: Imperial College London
Year: 2016

description: Optical projection tomography is a “mesoscopic” imaging technique, which fills a size gap in imaging, between techniques that provide subcellular resolution such as confocal laser scanning microscopy and cellular/whole body imaging techniques such as PET/MRI. OPT provides three dimensional (3D) whole body imaging utilising absorption or fluorescence contrast in mesoscopic (1-10 mm), transparent samples. This has the potential to be developed for use in biomedical research, for example in drug screening, developmental biology, and the study of disease mechanisms. To fully exploit the advantages of OPT, we image live zebrafish. These are the optimal size for imaging, and transparent mutants are readily available resulting in less scattering of optical radiation. They are also genetically tractable and many transgenic lines with fluorophore labels have been created. This thesis reports on the use of optical projection tomography (OPT) and fluorescence lifetime imaging (FLIM) to detect enzyme activity in whole live zebrafish. FRET biosensors for Caspase 1 and 3 activity were generated and the Caspase 3 FRET biosensor was validated in mammalian cell culture. Transgenic zebrafish expressing the biosensors ubiquitously under control of the ubiquitin (Ubi), macrophage (mpeg) and neutrophil (LysC) promoters were generated and used to validate the biosensors within live zebrafish. Caspase 3 is activated as part of the apoptotic pathway, in response to gamma irradiation. After exposure to 25 Gy irradiation, Caspase 3 activity is evident in the head region of 24 hpf zebrafish ubiquitously expressing the Caspase 3 biosensor, through both confocal and OPT FLIM imaging. FLIM OPT imaging allows visualisation of activity via production of 3D lifetime maps. Programs were generated to enable qualification and quantification of the data. Preliminary validation of the novel Caspase 1 biosensor indicates the biosensor is functional and it is possible to use FLIM to detect Caspase 1 activity in live zebrafish, in response to immune activation via tail transection. Overall, these findings demonstrate that FLIM OPT is a useful tool in mesoscopic imaging, able to identify enzyme activity in a whole live zebrafish, in 3D.