cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Caring, Courage and Curiosity: Reflections on our roles as scholars in organizing for a sustainable future
Creators: name: Howard-Grenville, Jennifer
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Theory Article
complexity
interdependence
organization theory
resilience
responsibility
sustainability
systems
vulnerability

description: The Covid-19 pandemic made important societal issues even more pressing and poignant to organizations. I explore how the pandemic surfaced attention to the vulnerability and resilience of organizations and organizing, and reflect on our responsibility as organizational scholars to think and act differently about our work as a result. I consider how we might do this individually and collectively, arriving at suggestions for how to advance organization theory and its relevance to contemporary organizing through: (1) directing our care to multiple issues that need attention; (2) having the courage to step away from familiar modes of inquiry and styles of theorizing to explore these; and (3) using our curiosity to develop nuanced explanations that match the complex, systemic nature of the issues themselves.
Implementation of Primary Palliative Care in five Belgian regions: A qualitative study on early identification of palliative care needs by general practitioners
Creators: name: Leysen, Bert
name: Schmitz, Olivier
name: Aujoulat, Isabelle
name: Karam, Marlène
name: Eynden, Bart Van Den
name: Wens, Johan
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: To deliver optimal palliative care, a Care Pathway for Primary Palliative Care (CPPPC) was developed. This CPPPC was implemented by general practitioners (GPs) in territories of five Belgian palliative care networks (2014–2016). Belgian doctors have much therapeutic freedom, and do not commonly follow guidelines. To assess how palliative care was provided by GPs before the CPPPC and its implementation project were presented publicly. Between 2013 and 2015, seven focus groups with GPs were conducted. Participants included 15 GPs in three French-speaking focus groups and 26 GPs in four Dutch-speaking focus groups, with diversity for age, gender, palliative care experience and practice context. Some GPs implemented the CPPPC later. GPs considered each palliative care case unique and disliked strict protocols. However, they expressed a need for peer review and reflective frameworks. GPs felt it is important to identify palliative care patients ‘timely’, but found this difficult. Screening methods help, but are not widely used. GPs struggled most with identifying palliative care needs in non-oncological patients. Bad news breaking was considered difficult. Continuity of care was considered very important. However, advance care planning seemed more widely practised by Dutch-speaking GPs than by French-speaking GPs. The taboo of palliative care provoked emotional discussions. Palliative care frameworks which help GPs to deliver ‘tailor-made’ care have more chance to be adopted than strict protocols. GPs should be given education for bad news breaking. Palliative care and advance care planning practices differ locally: guideline dissemination plans should respect these local differences.
E-RIHS IP D6.3 Report on Cooperation Activities: Approach and Advancement
Creators: name: Castillejo, Marta
name: Carmona, Paula
name: Striova, Jana
name: Benassi, Laura
name: Cazenave, Elodie
name: Caussé, Alexander
name: Petitcol, Rémi
name: Virgili, Vania
Publisher: name: Zenodo
Year: 2023
Subjects: international cooperation
collaboration strategy
common practice policies

description: This document reports on the approach that will be adopted by E-RIHS IP for setting up a collaboration strategy with relevant projects and research infrastructures at EU and global level towards the establishment of common practice policies in the framework of the future European Research Infrastructure Consortium (ERIC). This strategy is based on previous advances aiming at the same goal of precedent or still ongoing projects, like E-RIHS PP and IPERION HS, and will be described here in terms of objectives and methodology. The set of concrete actions proposed will ensure that existing links with other European Strategy Forum on Research Infrastructures (ESFRI) projects and landmarks and international research infrastructures and consortia, operating in physical, natural science and social and cultural innovation domains, are fully exploited and that new links with other relevant initiatives are created.
Ocular adverse events associated with immune checkpoint inhibitors: a novel multidisciplinary management algorithm
Creators: name: Shahzad, Orthi
name: Thompson, Nicola
name: Clare, Gerry
name: Welsh, Sarah
name: Damato, Erika
name: Corrie, Philippa
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Case Series
checkpoint inhibitor
corticosteroids
immune-related adverse events
ocular
uveitis

description: Ocular immune-related adverse events (IrAEs) associated with use of checkpoint inhibitors (CPIs) in cancer therapeutics are relatively rare, occurring in approximately 1% of treated patients. Recognition and early intervention are essential because the degree of tissue damage may be disproportionate to the symptoms, and lack of appropriate treatment risks permanent loss of vision. International guidelines on managing ocular IrAEs provide limited advice only. Importantly, local interventions can be effective and may avoid the need for systemic corticosteroids, thereby permitting the continuation of CPIs. We present a single institution case series of eight affected patients managed by our multidisciplinary team. Consistent with previously published series and case reports, we identified anterior uveitis as the most common ocular IrAE associated with CPIs requiring intervention. Based on our experience, as well as published guidance, we generated a simple algorithm to assist clinicians efficiently manage patients developing ocular symptoms during treatment with CPIs. In addition, we make recommendations for optimising treatment of uveitis and address implications for ongoing CPI therapy.
"Whippets"-induced vitamin B12 deficiency and dorsal column degeneration
Creators: name: Zeenat Qureshi Stroke Institutes
Publisher: name: Zenodo
Year: 2023

description: A 32 year old pregnant woman at 11th week gestation presented with 2 weeks of progressive gait difficulty and ascending weakness. Patient admitted to recreational inhalation of nitrous oxide from whipped-cream bulbs "whippets". On examination, she had mild weakness in her extremities. Laboratory examination was significant for a low serum cobalamin (vitamin B12) level. Furthermore, homocysteine and methylmalonic acid were elevated. Parietal cell and intrinsic factor antibodies were negative. She was started on vitamin B12 injections and transferred to an acute rehabilitation facility
Extract : informing microservice extraction decisions from the bottom-up
Creators: name: Akamoto, Shizuko
Publisher: name: University of British Columbia
Year: 2023

description: Microservice architectures are a popular approach for modernizing legacy monolithic systems. However, transforming an existing monolith into microservices is a complex task for developers. In practice, developers typically perform the decomposition iteratively, extracting one service at a time. Unfortunately, most existing tools do not adequately support such extraction tasks, as they aim to transform a monolith into microservices architecture at once. This paper presents Extract, a prototype tool that aligns with the developer's individual workflow for performing a single microservice extraction task. Extract empowers developers to analyze the particular classes and methods within the monolith that they intend to migrate to a new microservice. Moreover, it offers human-in-the-loop support, allowing developers to make well-informed decisions regarding the extraction process and explore alternative designs. We evaluate Extract with four case studies involving open-source monolithic applications. These studies serve to demonstrate how the approach aids developers in making practical decisions during the extraction process. Furthermore, we compare the outcomes of Extract's service designs with manually decomposed microservices for further analysis.
Map #20, 5MT10684, Kiva 108, Surface 1
Creators: name: DeVos, Jim
Year: 2019
Subjects: subject: Southwestern Colorado
valueUri: https://core.tdar.org/browse/geographic-keyword/2810/southwestern-colorado
subject: Southwestern US
valueUri: https://core.tdar.org/browse/geographic-keyword/84604/southwestern-us
subject: Basketmaker III
valueUri: https://core.tdar.org/browse/temporal-keyword/78/basketmaker-iii
subject: Pueblo II
valueUri: https://core.tdar.org/browse/temporal-keyword/55/pueblo-ii
subject: Pueblo III
valueUri: https://core.tdar.org/browse/temporal-keyword/56/pueblo-iii
subject: 5MT10684
valueUri: https://core.tdar.org/browse/site-name/118034/5mt10684
subject: Dry Ridge site
valueUri: https://core.tdar.org/browse/site-name/118033/dry-ridge-site

description: Site 5MT10684, Kiva 108, Surface 1.
NOTCH3 variants are more common than expected in the general population and associated with stroke and vascular dementia: an analysis of 200 000 participants
Creators: name: Cho, Bernard P H
name: Nannoni, Stefania
name: Harshfield, Eric L
name: Tozer, Daniel
name: Gräf, Stefan
name: Bell, Steven
name: Markus, Hugh S
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Cerebrovascular disease
1506

description: Background: Cysteine-altering NOTCH3 variants identical to those causing the rare monogenic form of stroke, CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy), have been reported more common than expected in the general population, but their clinical significance and contribution to stroke and dementia risk in the community remain unclear. Methods: Cysteine-altering NOTCH3 variants were identified in UK Biobank whole-exome sequencing data (N=200 632). Frequency of stroke, vascular dementia and other clinical features of CADASIL, and MRI white matter hyperintensity volume were compared between variant carriers and non-carriers. MRIs from those with variants were visually rated, each matched with three controls. Results: Of 200 632 participants with exome sequencing data available, 443 (~1 in 450) carried 67 different cysteine-altering NOTCH3 variants. After adjustment for various covariates, NOTCH3 variant carriers had increased risk of stroke (OR: 2.33, p=0.0004) and vascular dementia (OR: 5.00, p=0.007), and increased white matter hyperintensity volume (standardised difference: 0.52, p<0.001) and white matter ultrastructural damage on diffusion MRI (standardised difference: 0.72, p<0.001). On visual analysis of MRIs from 47 carriers and 148 matched controls, variants were associated with presence of lacunes (OR: 5.97, p<0.001) and cerebral microbleeds (OR: 4.38, p<0.001). White matter hyperintensity prevalence was most increased in the anterior temporal lobes (OR: 7.65, p<0.001) and external capsule (OR: 13.32, p<0.001). Conclusions: Cysteine-changing NOTCH3 variants are more common in the general population than expected from CADASIL prevalence and are risk factors for apparently ‘sporadic’ stroke and vascular dementia. They are associated with MRI changes of small vessel disease, in a distribution similar to that seen in CADASIL.
Burden of metabolic syndrome among primary care patients in Crete, Greece: A descriptive study
Creators: name: Anastasaki, Marilena
name: Papadakis, Sophia
name: Linardakis, Manolis
name: Anyfantakis, Dimitrios
name: Symvoulakis, Emmanouil K.
name: Lionis, Christos
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Metabolic Syndrome (MetS) is a clustering of abdominal obesity, hypertriglyceridaemia, low HDL cholesterol, hyperglycaemia and hypertension. Early identification of MetS is important for preventing cardiovascular disease (CVD). MetS has not been systematically explored in Greek primary care. To examine MetS frequency among primary care patients 40 years of age or older in Crete. A descriptive study was conducted (July–December 2015). General practitioners, randomly selected from regional physician listings, recruited consecutive patients, 40 years of age or older, visiting their practice. Chart audits were completed for eligible patients using medical records, including demographics and cardiovascular risk factors (hypertension, dyslipidaemia, diabetes mellitus). MetS was defined using the revised NCEP ATP III criteria. Frequencies with 95% confidence intervals were calculated. Gender differences were explored using Chi-square and Mann–Whitney tests. Our sample consisted of 815 patients (55.7% female; mean age 65.2 years; range 40–98 years) from 44 GP practices. Overall, 73.6% (95% CI 70.4, 76.6) were identified with MetS, with a higher proportion of males (75.6%; 95% CI 71.0, 79.8) than females (72.0%; 95% CI 67.8, 76.0). Among the total sample, relatively high rates of hypertension (males: 64.5%; 95% CI 59.9, 70.0 and females: 61.1%; 95% CI 56.8, 65.8), dyslipidaemia (males: 69.3%; 95% CI 64.3, 74.1 and females: 63.5%; 95% CI 59.3, 68.0), diabetes mellitus (males: 46.9%; 95% CI 42.2, 52.4 and females: 36.5%; 95% CI 32.5, 41.6) and coronary heart disease (males: 21.2%; 95% CI 17.0, 25.2 and females: 6.2%; 95% CI 4.2, 8.6) were documented. MetS and CVD risk factors were encountered at high frequencies in the studied population of primary care patients in Crete.
Arsenic cmQTL
Creators: name: O'Connor, Callan
name: Keele, Gregory R
name: Gatti, Daniel
name: Martin, Whitney
name: Stodola, Tim
name: Hoffman, Brian
name: Churchill, Gary
name: Korstanje, Ron
name: Reinholdt, Laura
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 310506
subject: Gene mapping
classificationCode: 310509
subject: Genomics

description: A high content imaging approach to studying the genetics of chemical exposure using dose response modeling of MMAIII-induced cell morphological changes.
Penetration of topical diclofenac into synovial tissue and fluid of osteoarthritic knees: a multicenter, randomized, placebo-controlled, pharmacokinetic study
Creators: name: Seefried, Lothar
name: Blyth, Mark
name: Maheshwari, Rohit
name: McDonnell, Stephen M.
name: Frappin, Guillaume
name: Hagen, Martina
name: Maybaum, Nadine
name: Moreira, Sebastian
name: Pandit, Hemant
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Original Research
diclofenac
nonsteroidal anti-inflammatory agents
osteoarthritis
pharmacokinetics; tissue distribution

description: Funder: GSK Consumer Healthcare S.A., Nyon, Switzerland
description: Background:: Topical diclofenac, a nonsteroidal anti-inflammatory drug, has proven efficacy and safety in the management of osteoarthritis pain. We investigated penetration of topical diclofenac into knee synovial tissue and fluid (primary objective) and evaluated relative exposure in the knee versus plasma (secondary objective). Methods:: In this phase I, double-blind, multicenter study, patients scheduled for arthroplasty for end-stage knee osteoarthritis were randomly assigned 2:1 to 4 g diclofenac diethylamine 2.32% w/w gel (92.8 mg diclofenac diethylamine, equivalent to 74.4 mg diclofenac, per application) or placebo gel, applied to the affected knee by a trained nurse/designee every 12 h for 7 days before surgery. Diclofenac concentrations were measured in synovial tissue, synovial fluid and plasma from samples obtained during surgery ⩾12 h after last application. Treatment-emergent adverse events (TEAEs) were evaluated. Results:: Evaluable synovial tissue or fluid samples were obtained from 45 (diclofenac n = 29; placebo n = 16) of 47 patients. All diclofenac-treated participants had measurable diclofenac concentrations in synovial tissue [geometric mean 1.57 (95% confidence interval (CI) 1.12, 2.20) ng/g] and fluid [geometric mean 2.27 (95% CI 1.87, 2.76) ng/ml] ⩾12 h after the last dose. Geometric mean (95% CI) ratio of diclofenac in synovial tissue:plasma was 0.32 (0.23, 0.45) and in synovial fluid:plasma was 0.46 (0.40, 0.54). TEAE rates were similar for diclofenac (55.2%) and placebo (58.8%); none were treatment related. Conclusions:: Topical diclofenac diethylamine 2.32% w/w gel penetrated into the osteoarthritic knee after repeated application and remained detectable in synovial tissue and fluid at the end of the final 12 h dosing cycle.
Map #30, Site 5MT2037, Midden 106 and Arbitrary Unit 104, Stratigrphic Profile
Creators: name: DeVos, Jim
Year: 2019
Subjects: subject: Southwestern Colorado
valueUri: https://core.tdar.org/browse/geographic-keyword/2810/southwestern-colorado
subject: Southwestern US
valueUri: https://core.tdar.org/browse/geographic-keyword/84604/southwestern-us
subject: Basketmaker III
valueUri: https://core.tdar.org/browse/temporal-keyword/78/basketmaker-iii
subject: Pueblo II
valueUri: https://core.tdar.org/browse/temporal-keyword/55/pueblo-ii
subject: Pueblo III
valueUri: https://core.tdar.org/browse/temporal-keyword/56/pueblo-iii
subject: 5MT2037
valueUri: https://core.tdar.org/browse/site-name/118042/5mt2037
subject: Pasquin Site
valueUri: https://core.tdar.org/browse/site-name/118041/pasquin-site

description: Site 5MT2037, Midden 106 and Arbitrary Unit 104, Stratigrphic Profile
Surinam
Creators: name: Şentürk, Recep
Publisher: name: Zenodo
Year: 2009
Subjects: Surinam
İslamiyet
Tarih
İslam Birliği

description: Surinam Güney Amerika'da en fazla göç veren ülkelerden biridir ve göç edilen ülkelerin ilk sırasında tarihi, kültürel ve ekonomik sebeplerden dolayı Hollanda bulunur. Azlığına rağmen nüfus çok çeşitli etnik ve dini topluluklardan meydana gelmektedir. Başlıca etnik gruplar Hintliler (% 27), Kreoller (% 18), Cavalılar (% 15), Marunlar (% 15), Melezler (% 13), yerli Kızılderililer '(% 4), Çinliler (% 2) ve beyazlardır (% 1). Siyah derili Kreoller ile kıyıdaki plantasyonlardan kaçarak ormanlara sığınan Marunlar eski Afrikalı kölelerin torunlarıdır. Marunlar'la Kızılderililer iç kesimdeki yağmur ormanlarında daha çok avetlık ve toplayıcılık yaparak geçinirler. Hintliler'le Cavalılar tarım ve diğer sektörlerde çalışır, Çinliler ticaretle uğraşırlar; beyazlar ise zengin sınıfı oluşturmaktadır. Nüfusun dini yapısı Hindu (% 27,4), Protestan(% 25,2), Katolik (% 22,8), müslüman(% 19,6) ve animistlerden (% 5) oluşur. Afrika kökenlilerin çoğunluğu hıristiyandır.
title: Green-field exploration strategy for de-risking geothermal projects in the Aachen-Weisweiler area, Germany – The “Field Scale Laboratory for Deep Geothermal Energy Rhineland” Project
Creators: name: Wellmann, Florian
name: Ritzmann, Oliver
name: Kettermann, Michael
name: Niederau, Jan
name: Aßhoff, Kira
name: Jüstel, Alexander
name: Strozyk, Frank
name: Reinsch, Thomas
name: Bracke, Rolf
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
The subsurface of the Aachen-Weisweiler area with its Carboniferous and Devonian carbonates is a green-field target location for testing and developing deep geothermal energy systems in North Rhine-Westphalia, Germany. Despite subsurface mining, surface mapping and isolated deep exploration wells and crustal seismic data, only sparse information on the deeper structures (down to 4,000 m), the spatial distribution of the reservoirs and reservoir properties has so far been recorded and/or published. Therefore, the complex structures of the faulted and folded Paleozoic layers remain unknown requiring further investigations. With the “Field Scale Laboratory for Deep Geothermal Energy Rhineland”, we aim to characterize the subsurface of the Aachen-Weisweiler area including its structural uncertainties, to quantify the reservoir properties of the carbonates and their associated parametric uncertainties to better describe the geological risk in exploring the reservoirs. Firstly, we constrain a geological model based on the publicly available surface and subsurface data and quantify its structural uncertainties. The model and the uncertainties are revised after the integration of vintage and newly acquired seismic data. Planned deep exploration wells will provide further constraints for the structural model but also deliver in-situ measurements of reservoir properties and geomechanical properties for subsequent thermo-hydraulic-mechanical modeling. The investigations contribute to the characterization of the potential geothermal reservoirs in this region, aid in the exploitation of the reservoirs, finding drilling locations for wells, and expand geological knowledge of the carbonates from other regions into Germany, hence, de-risking the geothermal plays in the Aachen-Weisweiler area.  
Blame Game Theory: Scapegoating, Whistleblowing and Discursive Struggles following Accusations of Organizational Misconduct
Creators: name: Roulet, Thomas J.
name: Pichler, Rasmus
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Theory Article
blame game
crisis
discourse theory
misconduct
scapegoating
whistleblowing

description: Research on organizational misconduct has examined how audiences generate discourses to make sense of behaviour that may transgress the line between right and wrong. However, when organizations are accused of misconduct, the resulting ambiguity also opens opportunities for organizations and their members to generate discourses aimed at deflecting blame. Little is known about how actors who are at risk of being held responsible actively respond to misconduct accusations by engaging in discursive strategies. To address this question, we build on crisis communication and discourse theory to integrate processes of scapegoating and whistleblowing into a holistic model. We develop a blame game theory – conceptualizing the sequence of discursive strategies employed by an organization and its members to strategically shift blame by attributing responsibility to others or denying misconduct. Our model identifies four blame game pathways as a function of two types of ambiguity: moral ambiguity and attributional ambiguity. We highlight accusations of misconduct as pivotal triggering events in the social construction of misconduct. By conceptualizing the discursive dynamics of strategic reactions to accusations of misconduct, our blame game theory contributes to the literature on organizational misconduct and has implications for research on social evaluations.
Adverse events of targeted therapies reported by patients with cancer treated in primary care
Creators: name: Roger, Samuel
name: Edeline, Julien
name: Campillo-Gimenez, Boris
name: Ventroux, Elodie
name: Marie-Eve Rouge-Bugat
name: Chapron, Anthony
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Targeted Therapies (TT) are among the therapeutic innovations for cancer treatment in outpatient settings. TT-related Adverse Events (AEs) are a source of loss of opportunity for patients if their management is inappropriate. The objective of this study was to describe the AE frequency and severity as reported by patients with cancer who received TT in ambulatory settings. A second objective was to describe the role of the general practitioner (GP) in the management of AEs. All patients who started TT at a French Regional Cancer Centre in 2017–2018 were eligible for this 12-month prospective study. A self-administered questionnaire was distributed at inclusion and returned after three months. In the questionnaire, patients listed all AEs that occurred during this period and rated their severity. Occurrence and severity were compared with the rating by a specialised nurse. Patients also indicated the health professional they contacted first for the reported AE. Among the 247 eligible patients, 15 were excluded and 144 responded to the questionnaire. Fourteen different TTs have been prescribed. Asthenia (92.4%) and anorexia (64.6%) were the most frequent AE. Patients’ AE severity rating was more severe than the nurse’s rating for all drugs (p Patients experienced an average of 4 AEs. AE severity rating was significantly different between patients and nurses. Patients do not always communicate AEs to health care professionals.
title: The role of basalts in the Earth’s carbon-cycle: lessons learnt from continental and ocean drilling investigations to tackle anthropogenic warming
Creators: name: Galerne, Christophe
name: Bach, Wolfgang
name: Lenhardt, Nils
name: Hasenclever, Jörg
name: Kopf, Achim
name: Kahl, Wolf-Achim
name: Wiggers, Christin
name: Götz, Annette
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
Permanent carbonate mineralisation in basalt is a promising solution for Carbon Capture and Storage of anthropogenic greenhouse gases without the risk of leakage. While this process is known to occur at relatively low temperatures below 100°C, new research on Large Igneous Provinces (LIPs) and young rift basins suggests that much of the thermogenic gases mobilised during contact metamorphism can remain trapped and mineralised in the sills that mobilised them. This discovery is the result of two distinct drilling investigations on land (KARIN) and at sea (IODP Exp 385). It shows that basalts may not only trigger the sudden release of thermogenic gas, but also represent an important carbon sink. The two examples of carbonate trapping in sills presented here are from the Karoo and Guaymas basins. Results indicate that a large fraction of epimagmatic fluids charged with thermogenic gas systematically penetrated inside the sills during cooling. Our numerical solutions suggest that in both cases the higher permeability of the sill acquired during cooling and crystallisation compared to that of its host, ultimately dictates the fate of the thermogenic gas that accumulates in the igneous body. On this basis, we conclude on the role of basalts in the Earth’s carbon cycle from a geological and anthropogenic perspective.
Map #471, Site 5MT10647, Pit Room 330, Surface 1; Pit Room 331, Surface 1; and Nonstructure 304 Surface 1
Creators: name: DeVos, Jim
Year: 2018
Subjects: subject: Southwestern Colorado
valueUri: https://core.tdar.org/browse/geographic-keyword/2810/southwestern-colorado
subject: Southwestern US
valueUri: https://core.tdar.org/browse/geographic-keyword/84604/southwestern-us
subject: Basketmaker III
valueUri: https://core.tdar.org/browse/temporal-keyword/78/basketmaker-iii
subject: Pueblo I
valueUri: https://core.tdar.org/browse/temporal-keyword/54/pueblo-i
subject: Pueblo II
valueUri: https://core.tdar.org/browse/temporal-keyword/55/pueblo-ii
subject: 5MT10647
valueUri: https://core.tdar.org/browse/site-name/118013/5mt10647
subject: Dillard Site
valueUri: https://core.tdar.org/browse/site-name/118012/dillard-site

description: Site 5MT10647, Pit Room 330, Surface 1; Pit Room 331, Surface 1; and Nonstructure 304 Surface 1
Multidisciplinary working in the management of axial and peripheral spondyloarthritis
Creators: name: Gudu, Tania
name: Jadon, Deepak R.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Extra-articular manifestations and comorbidities in spondyloarthritis
combined clinics
multidisciplinary team meetings
multidisciplinary working
spondyloarthritis

description: Multidisciplinary (MD) care is essential in the management of patients with spondyloarthritis (SpA) and is one of the main pillars of disease management and patient care. However, evidence supporting the effectiveness and benefits of this strategy in SpA is scarce. In this review we discuss the three types of MD care models: (i) combined clinics (MD units), including ‘face to face’, ‘parallel’ and ‘circuit approach’ clinics; (ii) MD team meetings; (iii) group consultations. The most frequently used model in SpA studies has been the ‘parallel’ combined clinic and usually encompasses a rheumatologist and another specialist, most commonly a dermatologist or a gastroenterologist, that work in tandem according to predefined referral criteria and treatment algorithms. MD working seems to improve the care of patients with SpA by a better identification and diagnosis of the disease, an earlier and more comprehensive treatment approach, and better outcomes for patients in terms of disease activity, physical function, quality of life and patient satisfaction. Nevertheless, challenges remain. Data on effectiveness and feasibility are scarce and are mostly derived from studies with design issues and often without a unidisciplinary care comparator arm. Although patient centricity is one of the core values of patient care and MD setting in SpA, the patient often does not play an active role in most of the MD settings studied or in common clinical practice. Further efforts should be made so that MD care reflects patients’ expectations and needs. Overcoming these limits will help to implement successfully SpA MD care in daily clinical practice and subsequently to achieve a higher quality of care for our patients.
title: Development of assessment tools for the identification of pain in Angus beef calves (Bos taurus)
Creators: name: Farghal Abdelnaser, Mostafa Mohamed
Publisher: name: Veterinary Medicine
Year: 2025
Subjects: subject: Pain
subject: Stress
subject: Welfare
subject: Calf grimace scale
subject: QBA
subject: Training
subject: Emotions
subject: Veterinary Science

description: Pain assessment in cattle is challenging due to limited pain assessment tools. This thesis aimed to develop a calf grimace scale (CGS) and adapt the qualitative behaviour assessment (QBA) to assess pain in Angus beef calves after surgical castration. Four studies were conducted in this thesis. In the first study, the CGS was developed, and its responsiveness to pain and stress caused by external factors was evaluated. In the second study, the impact of targeted training sessions on the reliability of the CGS was explored. In the third study, the validity of the CGS following COSMIN (Consensus-based standards for the selection of health measurement instruments) guidelines was assessed. In the last study, the use of QBA for assessing emotional states related to acute pain was investigated, and its validity was evaluated. The CGS was developed for front and side views, including 6 facial action units: ear position, orbital tightening, tension above the eye, nostril dilation, straining of chewing muscle (only side view), and mouth opening. The CGS was responsive to pain and stress factors such as changes in environment and dam separation. The CGS was a multidimensional scale with excellent intra- (ICC > 0.87) and inter-observer reliability (ICC = 0.92), robust construct validity, and moderate criterion validity (rs = 0.49 and 0.42 for front and side views, respectively). The side view of the CGS presented the best performance under unrestrained conditions with specificity, sensitivity, and accuracy above 70% when using a threshold score of 0.5/1. Observers’ training improved their reliability and helped achieve scoring consistency using the CGS. In addition, results highlighted that multiple training sessions improved observer reliability compared to one training session. The QBA was able to identify emotional states related to acute pain in beef calves with robust construct validity, strong inter- and intra-observer reliability for some dimensions, and moderate criterion validity for some dimensions (rs = 0.18–0.77). In conclusion, this thesis proposed two measures, the CGS and QBA, as reliable and valid tools for assessing pain and emotional states related to acute pain in Angus calves, respectively.
Dementia in Hungary: General practitioners’ routines and perspectives regarding early recognition
Creators: name: Balogh, Réka
name: Imre, Nóra
name: Papp, Edina
name: Kovács, Ildikó
name: Heim, Szilvia
name: Karádi, Kázmér
name: Hajnal, Ferenc
name: Pákáski, Magdolna
name: Kálmán, János
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Neuroscience
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Undetected dementia in primary care is a global problem. Since general practitioners (GPs) act as the first step in the identification process, examining their routines could help us to enhance the currently low recognition rates. The study aimed to explore, for the first time in Hungary, the dementia identification practices and views of GPs. In the context of an extensive, national survey (February-November 2014) 8% of all practicing GPs in Hungary (n = 402) filled in a self-administered questionnaire. The questions (single, multiple-choice, Likert-type) analysed in the present study explored GPs’ methods and views regarding dementia identification and their ideas about the optimal circumstances of case-finding. The vast majority of responding GPs (97%) agreed that the early recognition of dementia would enhance both the patients’ and their relatives’ well-being. When examining the possibility of dementia, most GPs (91%) relied on asking the patients general questions and only a quarter of them (24%) used formal tests, even though they were mostly satisfied with both the Clock Drawing Test (69%) and the Mini-Mental State Examination (65%). Longer consultation time was chosen as the most important facet of improvement needed for better identification of dementia in primary care (81%). Half of the GPs (49%) estimated dementia recognition rate to be lower than 30% in their practice. Hungarian GPs were aware of the benefits of early recognition, but the shortage of consultation time in primary care was found to be a major constraint on efficient case-finding.
Estrogen metabolites in a small cohort of patients with idiopathic pulmonary arterial hypertension
Creators: name: Denver, Nina
name: Homer, Natalie Z.M.
name: Andrew, Ruth
name: Harvey, Katie Y.
name: Morrell, Nicholas
name: Austin, Eric D.
name: MacLean, Margaret R.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Research Letter
pulmonary hypertension experimental
metabolism
sex
pulmonary hypertension

description: Increased risk and severity of idiopathic pulmonary arterial hypertension (iPAH) is associated with elevated estradiol in men and postmenopausal women. Pulmonary arteries synthesise estradiol via aromatase and metabolise it via CYP1B1 to mitogenic metabolites; SNPs in aromatase and CYP1B1 have been associated with PAH. This suggests that estradiol metabolism could be altered in iPAH. This proof-of-concept study profiles estradiol and several metabolites of estradiol simultaneously in serum from iPAH patients and controls. We show that the estradiol and metabolite profile is altered in iPAH and that 16-hydroxyestrone and 16-hydroxyestradiol accumulate in iPAH patients with 16-hydroxyestrone levels relating to disease severity.
An integrated system for ultrasound-based surgical navigation of iliosacral screws
Creators: name: Pandey, Prashant
Publisher: name: University of British Columbia
Year: 2023

description: Pelvic fractures require a complex surgery to realign the fracture and stabilize the pelvic ring. The conventional method for placing iliosacral screws (ISS) in the pelvis relies heavily on intraoperative fluoroscopy. However, due to the narrow sacral passage the screw must pass through, this technique is susceptible to high rates of screw malplacement which can lead to iatrogenic complications. Additionally, fluoroscopy requires ionizing radiation and therefore exposes the surgical staff to harm. This thesis proposes and evaluates an alternative surgical protocol using a navigation system based on ultrasound (US) imaging, which enables accurate bone surface imaging without requiring ionizing radiation. This system's development involves four contributions, the first two of which focus on the requirement of automatically identifying bone in US. First, we developed a multi-institutional US bone imaging dataset and corresponding evaluation framework, allowing for more systematic evaluation of US bone segmentation algorithms. Using this, we benchmarked six segmentation algorithms on thousands of US images and found deep convolutional neural networks are the most accurate. Second, we characterized a wide range of uncertainty estimation techniques and novel loss functions for US bone segmentation, and found that deep ensembling used with versions of the binary cross entropy loss can significantly improve segmentation (mean Dice: 0.75) and calibration errors (mean expected calibration error: 0.24%). Third, we validated multiple graphical visualizations, and found that bullseye visualizations achieve the best ISS targeting with mean distance and angulation errors of 0.51 mm and 0.55°. Finally, we combined these components to develop an integrated US-based surgical navigation system which we call NOFUSS (Navigated Orthopaedic Fixation using Ultrasound System). We surgically inserted ISSs in human cadaver specimens using NOFUSS, and compared its accuracy and efficiency to the conventional fluoroscopic-based surgery. We found that with NOFUSS, ISSs can be placed with comparable accuracy as fluoroscopy guidance, while requiring no intraoperative radiation and with a 60% reduction in median insertion times. This work demonstrates that combining US imaging with surgical navigation techniques is feasible and can likely enable surgeons to perform ISS insertions with accuracy and efficiency comparable to conventional procedures, but with little or no radiation exposure.
Targeting translational read-through of premature termination mutations in BMPR2 with PTC124 for pulmonary arterial hypertension
Creators: name: Long, Lu
name: Yang, Xudong
name: Southwood, Mark
name: Moore, Stephen
name: Crosby, Alexi
name: Upton, Paul D.
name: Dunmore, Benjamin J.
name: Morrell, Nicholas W.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Research Article
pulmonary endothelium
mutations
translational research

description: Pulmonary arterial hypertension is a fatal disorder of the lung circulation in which accumulation of vascular cells progressively obliterates the pulmonary arterioles. This results in sustained elevation in pulmonary artery pressure leading eventually to right heart failure. Approximately, 80% of familial and 20% of sporadic idiopathic pulmonary arterial hypertension cases are caused by mutations in the bone morphogenetic protein receptor type 2 (BMPR2). Nonsense mutations in BMPR2 are amongst the most common mutations found, where the insertion of a premature termination codon causes mRNA degradation via activation of the nonsense-mediated decay pathway leading to a state of haploinsufficiency. Ataluren (PTC124), a compound that permits ribosomal read-through of premature stop codons, has been previously reported to increase BMPR2 protein expression in cells derived from pulmonary arterial hypertension patients harbouring nonsense mutations. In this study, we characterised the effects of PTC124 on a range of nonsense BMPR2 mutations, focusing on the R584X mutation both in vitro and in vivo. Treatment with PTC124 partially restored BMPR2 protein expression in blood outgrowth endothelial cells isolated from a patient harbouring the R584X mutation. Furthermore, a downstream bone morphogenetic protein signalling target, Id1, was rescued by PTC124 treatment. Mutant cells also exhibited increased lipopolysaccharide-induced permeability, which was reversed by PTC124 treatment. Increased proliferation and apoptosis in R584X blood outgrowth endothelial cells were also significantly reduced by PTC124. Moreover, oral PTC124 increased lung BMPR2 protein expression in mice harbouring the R584X mutation (Bmpr2+/R584X). Our findings provide support for future experimental medicine studies of PTC124 in pulmonary arterial hypertension patients with specific nonsense BMPR2 mutations.
title: LabInfrastructure@Geo.X – A Laboratory Infrastructure Search Portal for the Geo.X Network
Creators: name: Luzi-Helbing, Manja
name: Hanisch, Marc
name: Fuchs, Hannes
name: Gödde, Hildegard
name: Hecht, Lutz
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
LI@Geo.X is a search portal for the laboratory infrastructure in the Geo.X network, jointly developed by the network partners. It supports collaborations and joint projects by providing information on instruments, analytical methods, contact persons, location of the laboratories, and links to their websites. LI@Geo.X is undergoing further development as LabInfrastructure@Geo.X in the framework of the Helmholtz DataHub Initiative. We extend the metadata scheme by adding, e.g., access information to the laboratories, user regulations, key and data publications. As technical improvements we implement:

a web-based user interface (change request form) for submitting new or modified laboratory metadata. This change request form is also equipped with a vocabulary tool for keywording instruments and analytical methods. For this we use the controlled vocabularies of the NASA GCMD instrument keywords and a vocabulary adapted for the Geo.X network.

a management interface which facilitates the decentralised editing and maintenance of the laboratory metadata.

semantic search options and filter functions which are aligned with the needs of the scientific target groups.

Including over 220 entries, LabInfrastructure@Geo.X cooperates with various Helmholtz initiatives and is embedded into the NFDI4Earth landscape.
Communication between Dutch community nurses and general practitioners lacks structure: An explorative mixed methods study
Creators: name: Nieuwboer, Minke S.
name: Sande, Rob Van Der
name: Maassen, Irma T.H.M
name: Rikkert, Marcel G.M Olde
name: Perry, Marieke
name: Marck, Marjolein A. Van Der
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Community nurses and general practitioners evaluate their patient-related communication to be poor. However, their actual communication has hardly been investigated and specific strategies for improvement are unclear. To explore actual community nurse-general practitioner communication in primary care and gain insights into communication style, and conversation structure and their determinants. A mixed-methods design was applied. Telephone conversations between community nurses and general practitioners in the Netherlands were recorded and transcribed verbatim. We measured structure and the duration of their conversations, and community nurses’ self-confidence towards general practitioners and their trust in and familiarity with the conversation partner. A thematic analysis was applied to the transcripts of the conversations. Correlations between these determinants were calculated using Spearman’s correlation coefficient. The 18 community nurses recorded 23 conversations with general practitioners. Qualitative analysis revealed that many conversations lacked structure and conciseness, i.e. the nurses started conversations without a clearly articulated question and did not provide adequate background information. The mean duration of their conversations with doctors was 8.8 min. Community nurses with higher self-confidence towards doctors communicated in a more structured way (p = 0.01) and general practitioners were more satisfied about the conversations (p = 0.01). This exploratory study of actual community nurse-doctor telephone conversations in primary care identified communication structure and nurse self-confidence towards general practitioners as key targets for the improvement of interprofessional communication, which may increase the effectiveness of community nurse-general practitioner collaboration.
Rana papua Less. 1758
Creators: name: Müller, F
Publisher: name: Zenodo
Year: 1885
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Amphibia
Anura
Ranidae
Rana
Rana papua

description: * Rana papua Less.
(Hylorana Dämelii Steind.)
Thursday-Insel v. F M. [1]
description: Published as part of Müller, F, 1885, Vierter Nachtrag zum Katalogder herpetologischen Sammlung des Basler Museums, pp. 668-717 in Verhandlungen der Naturforschenden Gesellschaft in Basel. 7 (3) on page 670, DOI: 10.5962/bhl.part.2388, http://zenodo.org/record/15183591
title: The tectonics of the Elbtalschiefergebirge-Osterzgebirge-Zone and the role of the Mid-Saxon-Fault
Creators: name: Schulze, Lea Marie
name: Kroner, Uwe
name: Görz, Ines
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
The Elbe zone constitutes a complex fault zone on the northern edge of the Bohemian Massif. As part of this zone, the Elbtalschiefergebirge is juxtaposed with the Lausitz to the northeast and the Osterzgebirge to the southwest. The tectonic boundary with the Osterzgebirge is traditionally defined by the Mid-Saxon-Fault. In the course of a tunnel project for the railroad line Dresden-Prague structural geological investigations were carried out. Here first results are presented. The entire area was overprinted by the Variscan orogeny and can be divided into three principal units. (i) The northeastern section consists of very low-grade metamorphic lithologies representing the remnants of an early Carboniferous synorogenic basin. The adjoining unit (ii) is predominantly made up by phyllites that differs from unit (i) by its stronger tectonic and metamorphic overprint and partly inverted stratigraphy. Mylonites on both sides of the Mid-Saxon-Fault reveal the existence of a ductile shear zone (iii) affecting high- to medium-grade metamorphic units of the Osterzgebirge as well as low-grade units of the Elbtalschiefergebirge. This Elbe-zone parallel, i.e., NW-SE striking shear zone suite is characterized by dextral strike slip tectonics and the transition from ductile to brittle-ductile material behavior. The existence of ESE-WNW to E-W stretching lineations on both sides of the Mid-Saxon-Fault , however, indicates a more complex tectonic evolution. Furthermore, the mylonites adjacent to the “Tourmaline-granite” of the Elbtalschiefergebirge resemble the shear zone rocks of the Erzgebirge. Thus, the traditional view of the Mid-Saxon-Fault as a strict tectonic boundary between both units must be questioned.