cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
GM 23 Tutorial: TUT 5 - Studies for Planning and Execution of HVDC Transmission Projects (slides)
Creators: Robert H. Renner
Jenny Zhou
Just Hendrik
Vajira Pathirana
Sahar Pirooz Azad
Kyeon Hur
Hiranya Suriyaarachchi
Abhay Kumar
Hakan Ergun
Publisher: name: IEEE
Year: 2023

This tutorial gives an overview of general steps/studies which are necessary during planning and execution phases of an HVDC project. They are structured in: Transmission Expansion Plan, Feasibility Studies, Specification Studies, Tender Phase, Project Execution.
This tutorial gives an overview of general steps/studies which are necessary during planning and execution phases of an HVDC project. They are structured in: Transmission Expansion Plan, Feasibility Studies, Specification Studies, Tender Phase, Project Execution.
The zebrafish model to identify new genes involved in thyroid development
Creators: name: Porreca, Immacolata
Publisher: name: Università degli Studi di Napoli Federico II
Year: 2010

description: Thyroid organogenesis is a very complex developmental process that leads to the formation of an organ able to produce specific hormones through specification, migration, structural organization and functional differentiation of thyroid precursor cells. In mammals, alteration of these mechanisms might be responsible for congenital hypothyroidism (CH), the most frequent inherited endocrine disease.
Thyroid development in fish is comparable to mammals at both ontogenetic and molecular levels: the thyroid develops from the endodermal tissue, at the midline of the pharyngeal floor, and its formation is subdivided into main successive steps shared with mammals. The genetic program involved in fish thyroid differentiation, including the activity of transcription factors such as Nkx2.1a, Pax8 and Hhex, is conserved with respect to expression patterns and functions.
To gain further insights on the genetic machinery implicated in normal thyroid development, and therefore in CH disease, an oligonucleotide microarray analysis was performed in mouse with the aim to identify genes differentially expressed during gland organogenesis. This approach highlighted a list of genes enriched in embryonic mouse thyroid. In the present work, the zebrafish model was used to perform functional analysis on fish counterparts of the murine thyroid enriched genes. Looking at the expression territories of the zebrafish orthologs, a very low correlation in thyroid expression profile between mouse and zebrafish was found: indeed, very few mouse thyroid expressed genes have their zebrafish ortholog being expressed in thyroid primordium. This observation strongly suggests that some changes concerning thyroid development occurred from lower to higher vertebrates; during evolution, the thyroid of higher vertebrates probably recruited new genetic pathways/functions by means of mutations occurred in cis-regulatory elements. Despite the low correlation in expression profiles, a new conserved function relevant for thyroid development was identified with this comparative approach; an anti-apoptotic function, represented by Bcl2 in mouse and bcl2l in zebrafish, was conserved during thyroid evolution. Knock-down experiments conducted by means of morpholinos injection, have revealed that bcl2l is regulated by the thyroid transcription factors and plays a relevant role in normal thyroid development. Indeed, bcl2l thyroid expression was lost in embryos deprived of the thyroid transcription factors, leading to thyroid degeneration via apoptosis. It is feasible to hypothesize that a conserved antiapoptotic function during thyroid evolution could counteract a putative proapoptotic function, ready to intervene if something fails during normal gland morphogenesis.
Computational solvation dynamics of oxyquinolinium betaine linked to trehalose
Creators: name: Heid, Esther
name: Schröder, Christian
Publisher: name: arXiv
Year: 2021
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Studying the changed water dynamics in the hydration layers of biomolecules is an important step towards fuller understanding of their function and mechanisms, but has shown to be quite difficult. The measurement of the time-dependent Stokes shift of a chromophore attached to the biomolecule is a promising method to achieve this goal, as published in J. Phys. Chem. Lett. 5 (2014), 1845, where trehalose was used as biomolecule, 1-methyl-6-oxyquinolinium betaine as chromophore and water as solvent. An overall retardation of solvent molecules is then obtained by comparison of the linked system to the same system without trehalose, but contributions from different subgroups of solvent molecules, for example molecules close to or far from trehalose, are unknown. The difficulty arising from these unknown contributions of retarded and possibly unretarded solvent molecules is overcome in this work by conducting computer simulations on this system and decomposing the overall signal into contributions from various molecules at different locations. We performed non-equilibrium molecular dynamics simulation using a polarizable water model and a non-polarizable solute model and could reproduce the experimental time-dependent Stokes shift accurately for the linked trehalose-oxyquinolinium and the pure oxyquinolinium over a wide temperature range, indicating the correctness of our employed models. Decomposition of the shift into contributions from different solvent subgroups showed that the amplitude of the measured shift is made up only half by the desired retarded solvent molecules in the hydration layer, but to another half by unretarded bulk water, so that measured relaxation times of the overall Stokes shift are only a lower boundary for the true relaxation times in the hydration layer of trehalose.
description: 10 pages
Geodesic flows on semidirect-product Lie groups: geometry of singular measure-valued solutions
Creators: name: Holm, Darryl D.
name: Tronci, Cesare
Publisher: name: arXiv
Year: 2008
Subjects: subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Physical sciences

description: The EPDiff equation (or dispersionless Camassa-Holm equation in 1D) is a well known example of geodesic motion on the Diff group of smooth invertible maps (diffeomorphisms). Its recent two-component extension governs geodesic motion on the semidirect product ${\rm Diff}\circledS{\cal F}$, where $\mathcal{F}$ denotes the space of scalar functions. This paper generalizes the second construction to consider geodesic motion on ${\rm Diff} \circledS\mathfrak{g}$, where $\mathfrak{g}$ denotes the space of scalar functions that take values on a certain Lie algebra (for example, $\mathfrak{g}=\mathcal{F}\otimes\mathfrak{so}(3)$). Measure-valued delta-like solutions are shown to be momentum maps possessing a dual pair structure, thereby extending previous results for the EPDiff equation. The collective Hamiltonians are shown to fit into the Kaluza-Klein theory of particles in a Yang-Mills field and these formulations are shown to apply also at the continuum PDE level. In the continuum description, the Kaluza-Klein approach produces the Kelvin circulation theorem.
description: 22 pages, 2 figures. Submitted to Proc. R. Soc. A
Effects of shuanghuanglian injection on the activities of CYP1A2, 2C11, 2D1 and 3A1/2 in rats in vivo and in vitro
Creators: name: Shi, Yuan
name: Xu, Juan
name: Qiao, Yan
name: Zhang, Wenlong
name: Liu, Duo
name: Qin, Mengnan
name: Liu, Gaofeng
name: Dong, Mei
Publisher: name: Taylor & Francis
Year: 2019
Subjects: Biochemistry
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Mental Health

description: Shuanghuanglian Injection (SHLI), one of the most popular herbal prescription in China, has been commonly used to treat pneumonia, tonsillitis, and other respiratory diseases caused by bacterium and virus. This study is to investigate the effects of SHLI on the activities of Cytochrome P450 (CYP) 1A2, 2C11, 2D1 and 3A1/2 in rats.Sixteen rats were randomly divided into two groups (SHLI-treated and blank control). They were administered SHLI or physiological saline for consecutive seven days. On day eight, 16 animals were administrated cocktail drugs as probe substrates of the four CYP in vivo. In addition, other four probe drugs were added, respectively, into incubation systems of rat liver microsomes (RLM) to assess the effects of SHLI on the four CYP isoforms in vitro.SHLI exhibited an inductive effect on CYP2C11 in vivo by decreasing Cmax, t1/2 and AUC0-∞ of tolbutamide, while the main pharmacokinetic parameters of caffeine, metoprolol and dapsone have no significant changes. In vitro study, SHLI showed no significant effects on the activities of CYP1A2, 2D1 and 3A1/2, but increasing the metabolism of tolbutamide in RLM.SHLI induced the activities of CYP2C11, but had no significant effects on the activities of CYP1A2, CYP2D1 and CYP3A1/2 in rats. Shuanghuanglian Injection (SHLI), one of the most popular herbal prescription in China, has been commonly used to treat pneumonia, tonsillitis, and other respiratory diseases caused by bacterium and virus. This study is to investigate the effects of SHLI on the activities of Cytochrome P450 (CYP) 1A2, 2C11, 2D1 and 3A1/2 in rats. Sixteen rats were randomly divided into two groups (SHLI-treated and blank control). They were administered SHLI or physiological saline for consecutive seven days. On day eight, 16 animals were administrated cocktail drugs as probe substrates of the four CYP in vivo. In addition, other four probe drugs were added, respectively, into incubation systems of rat liver microsomes (RLM) to assess the effects of SHLI on the four CYP isoforms in vitro. SHLI exhibited an inductive effect on CYP2C11 in vivo by decreasing Cmax, t1/2 and AUC0-∞ of tolbutamide, while the main pharmacokinetic parameters of caffeine, metoprolol and dapsone have no significant changes. In vitro study, SHLI showed no significant effects on the activities of CYP1A2, 2D1 and 3A1/2, but increasing the metabolism of tolbutamide in RLM. SHLI induced the activities of CYP2C11, but had no significant effects on the activities of CYP1A2, CYP2D1 and CYP3A1/2 in rats.
Investigation of NOx in piloted stabilized methane-air diffusion flames using Finite-rate and Infinitely-fast chemistry based combustion models
Creators: name: Saini, Rohit
name: Prakash, Swetha
name: De, Ashoke
name: Yadav, Rakesh
Publisher: name: arXiv
Year: 2021
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: The present work reports on the numerical investigation of NOx in three turbulent piloted diffusion flames of different levels of extinction. The study involves two-dimensional axisymmetric modeling of combustion in these flames with fairly detailed chemistry, i.e. GRI 3.0 mechanism. The main focus of the study is to analyze the effects of the two different combustion model approaches, such as infinitely fast chemistry based unsteady flamelet and finite rate chemistry based EDC, in predicting the NOx formation in three piloted methane jet flames (Sandia D, E, and F). The EDC approach is able to predict the passive scalar quantities but shows over-prediction in the reactive scalar quantities and NO prediction, while the unsteady flamelet modeling is found to be essential in predicting the accurate formation of slow kinetic species like NOx. The inability of flamelet and EDC approach in capturing localized flame extinction is observed, which lead to an over-prediction of NOx at larger downstream locations. Further, the dominance of NOx formation pathways is investigated in all three flames.
Agile Design of Domain-Specific Accelerators and Compilers Slides
Creators: Priyanka Raina
Publisher: name: IEEE
Year: 2023

Webinar Slides
Abstract: With the slowing of Moore's law, computer architects have turned to domain-specific hardware accelerators to improve the performance and efficiency of computing systems. However, programming these systems entails significant modifications to the software stack to properly leverage the specialized hardware. Moreover, the accelerators become obsolete quickly as the applications evolve. What is needed is a structured approach for generating programmable accelerators and for updating the software compiler as the accelerator architecture evolves with the applications. In this talk, I will describe a new agile methodology for co-designing programmable hardware accelerators and compilers. Our methodology employs a combination of new programming languages and formal methods to automatically generate the accelerator hardware and its compiler from a single specification. This enables faster evolution and optimization of accelerators, because of the availability of a working compiler. I will showcase this methodology using Amber, a coarse-grained programmable accelerator for imaging and machine learning (ML) we designed and fabricated using our flow in TSMC 16 nm technology. I will show how we agilely evolved Amber into Onyx, our next generation accelerator, using an application-driven design space exploration framework called APEX enabled by our hardware-compiler co-design flow.
Design strong anomalous Hall effect via spin canting in antiferromagnetic nodal line materials
Creators: name: Le, Congcong
name: Felser, Claudia
name: Sun, Yan
Publisher: name: arXiv
Year: 2021
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The interplay between magnetism and topological electronic structure offers a large freedom to design strong anomalous Hall effect (AHE) materials. A nodal line from band inversion is a typical band structure to generate strong AHE. Whereas, in most collinear antiferromagnets (AFMs), the integration of Berry curvatures on Brillouin zone is forced to zero by the joint $TO$ symmetry, where $T$ and $O$ are time reversal and a space group operation, respectively. Even with inverted band structures, such kind of AFM cannot have AHE. Therefore, so far, AFM nodal line band structures constructed by spin degenerated bands didn't get much attentions in AHE materials. In this work, we illustrate that such kind of band structure indeed provides a promising starting point to generated strong local Berry curvature by perturbations and, therefore, strong intrinsic AHE. In specific AFM compounds of $A$MnBi$_2$($A$=Ca and Yb) with inverted band structure, we found a strong AHE induced by a weak spin canting, and due to nodal line in the band structure the anomalous Hall conductivity keeps growing as the canting angle increases. Since such spin-canting can be adjusted via doping experimentally, it provides another effective strategy to generate and manipulate strong AHE
Additional file 1: of Adaptation mechanism and tolerance of Rhodopseudomonas palustris PSB-S under pyrazosulfuron-ethyl stress
Creators: name: Luo, Xiang-Wen
name: Zhang, De-Yang
name: Zhu, Teng-Hui
name: Zhou, Xu-Guo
name: Peng, Jing
name: Zhang, Song-Bai
name: Liu, Yong
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Figure S1. Comparison of results obtained through protein expression analysis (blue bars) or qRT-PCR (red bars). The height of the bars indicate the fold changes. Identification numbers of the analyzed proteins are indicated. Figure S2. Gene ontology (Go) enrichment of the identified up- or down-regulated proteins in R. palustris PSB-S cells treated with 50 μg/ml pyrazosulfuron-ethyl. A protein was considered to be differentially expressed in the pyrazosulfuron-ethyl-treated R. palustris PSB-S cells if t < 0.05. The GO enrichment analyses were performed using Blast2GO. (A) Number of proteins belonging to various groups in the biological process category. (B) Number of proteins belonging to various groups in the molecular function category. (C) Number of proteins belonging to various groups in the cellular localization category. Table S1. Differentially expressed proteins during R.palustris PSB-S treated with 50 mg/L pyrazosulfuron. Table S2. Primers for qRT-PCR. (PDF 293 kb)
Normal-Superfluid Interface for Polarized Fermion Gases
Creators: name: Van Schaeybroeck, Bert
name: Lazarides, Achilleas
Publisher: name: arXiv
Year: 2008
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Recent experiments on imbalanced fermion gases have proved the existence of a sharp interface between a superfluid and a normal phase. We show that, at the lowest experimental temperatures, a temperature difference between N and SF phase can appear as a consequence of the blocking of energy transfer across the interface. Such blocking is a consequence of the existence of a SF gap, which causes low-energy normal particles to be reflected from the N-SF interface. Our quantitative analysis is based on the Hartree-Fock-Bogoliubov-de Gennes formalism, which allows us to give analytical expressions for the thermodynamic properties and characterize the possible interface scattering regimes, including the case of unequal masses. Our central result is that the thermal conductivity is exponentially small at the lowest experimental temperatures.
description: 11 pages, 5 figures
Examining the Association Between Infertility, Pregnancy Intention, and Postpartum Depression
Creators: name: Barber, Gabriela Anita
Publisher: name: Digital Repository at the University of Maryland
Year: 2019
Subjects: subject: Public health
subject: Infertility
subject: Postpartum depression
subject: PRAMS
subject: Pregnancy
subject: Pregnancy intention

description: While much research has studied postpartum depression (PPD), few studies have examined PPD in women who become pregnant through the use of fertility treatments. The process of experiencing infertility and its treatment may alter the risk of developing PPD. We utilized data from The Pregnancy Risk Assessment Monitoring System (PRAMS; unweighted N=145,036) to compare PPD symptomatology between women who had unintended pregnancies (an at-risk group for PPD), women who conceived naturally/intentionally, and women who conceived using fertility services. We show that women who used fertility treatments did not differ from women who conceived naturally in regards to PPD. The women who utilized fertility enhancing drugs in comparison to insemination or assisted reproductive technologies had higher depressive symptoms. Therefore, our results suggest that the type of fertility treatment utilized may be important for clinicians to consider when working with these women as they transition into the postpartum period.
Slides for: LiDAR for Autonomous Driving: The Principles, Challenges and Trends
Creators: You Li
Publisher: name: IEEE
Year: 2023

Slides for: SPS Webinar, June 16, 2023, Dr. You Li, Dr. Javier Ibanez-Guzman
Autonomous vehicles rely on their perception systems to acquire information about their immediate surroundings. It is necessary to detect the presence of other vehicles, pedestrians, and other relevant entities. Safety concerns and the need for accurate estimations have led to the introduction of Light Detection and Ranging LiDAR systems in complement to camera or radar based perception systems. This webinar will present a review of state of the art automotive LiDAR technologies. Meanwhile, starting from different perception requirements of autonomous driving applications, the presenter will systematically analyze the strengths of LiDAR systems and their future for autonomous vehicles.
Synthetic heme-proteins in biosensors development
Creators: name: Ringhieri, Paola
Publisher: name: Università degli Studi di Napoli Federico II
Year: 2010

description: A biosensor is an analytical device that relies on a biological recognition element, such as an enzyme, an antibody, a DNA fragment, which communicates with a signal transducer, thus providing a measurable response related to the concentration of an analyte.
Currently, electrochemical biosensors, which exploit an electron transfer (ET) event at a solid electrode for the signal transduction, are the larger and most promising biosensor category in terms of ease of construction, costs, versatility, tunability and miniaturization (up to the nanoscale) for in vivo applications. A real breakthrough toward the development of electrochemical systems with superior selectivity, stability and durability is represented by the third generation biosensors. These devices exploit the unmediated direct electron transfer occurring at interfaces made up of an electrode immobilized redox-active specie, with a current transduction of the biological interaction, resulting in an amperometric detection of the analyte. An attractive feature of systems based on direct electron transfer is the possibility of modulating the properties of the analytical device using protein modification with genetic or chemical engineering techniques. Efficient direct electron transfer (DET) reactions have been reported for a restricted number of redox enzymes. The majority of these redox enzymes contain metal sites and particularly heme. Nevertheless, several studies based on heme-proteins adsorbed or immobilized on various electrodes showed that high-molecular weight enzymes are not amenable to direct electrical communication with the electrode.
Our strategy to overcome the above limitations is the exploitation of artificial low-molecular weight proteins, designed on rational bases, to possess the required activity. In our laboratory, a new class of heme-peptide conjugate, named Mimochromes, have been developed, with the aim of understanding the effects of the peptide chain composition and conformation in  modulating the heme redox potential. The main features of these molecules are the covalent structure and the well defined helical conformation of the peptide chains linked to the deuteroporphyrin ring.
The presented work exploits the use of two different class of Mimochromes, the penta-coordinated Fe(III)-Mimochrome VI and the esa-coordinated Fe(III)-Mimochrome IV Lys3, in biosensor technology. These two artificial molecules were used as bio-recognition elements/signal transducers for biosensing. The aim of this thesis was to develop and optimise catalytic and affinity-based biosensors for the rapid screening of target analytes in complex matrices. The electrochemical properties of the two Mimochromes were studied by voltammetric techniques, then they were suitably immobilized on a gold electrode surface to achieve the biosensors construction and finally the analyte recognition was performed.
title: Berichte über Landwirtschaft - Zeitschrift für Agrarpolitik und Landwirtschaft, Sonderheft 227, Juli 2019
title: Sonderheft 227, Juli 2019
titleType: AlternativeTitle
Creators: name: Berichte über Landwirtschaft-Zeitschrift Für Agrarpolitik Und Landwirtschaft
Publisher: name: Berichte über Landwirtschaft - Zeitschrift für Agrarpolitik und Landwirtschaft
Year: 2019

description: Zur effektiven Gestaltung der Agrarumwelt- und Klimaschutzpolitik im Rahmen der Gemeinsamen Agrarpolitik der EU Stellungnahme des Wissenschaftlichen Beirates für Agrarpolitik, Ernährung und gesundheitlichen Verbraucherschutz beim BMEL (2019)
description: Zur effektiven Gestaltung der Agrarumwelt- und Klimaschutzpolitik im Rahmen der Gemeinsamen Agrarpolitik der EU Designing an effective agri-environment-climate policy as part of the post-2020 EU Common Agricultural Policy Concevoir une politique agro-environnementale et climatique efficace dans le cadre de la Politique agricole commune de l’UE après 2020
Concentration and Detection of Hydrophobic Analytes using Modified Paper-SERS
Creators: name: Virgile, Sean Michael
Publisher: name: Digital Repository at the University of Maryland
Year: 2018
Subjects: subject: Bioengineering

description: Surface Enhanced Raman Spectroscopy (SERS) has been used to measure trace quantities of analytes and cost-effective paper-based SERS substrates have been used in the field to detect heroin and fentanyl in low-resource settings. However, due to the inherent properties of paper and the manufacturing process, these SERS substrates have limited capabilities in detection of lipophilic and hydrophobic analytes. This is of critical importance in markets such as the detection of delta9-THC, which is found in trace amounts (parts per billion) in saliva of intoxicated drivers. In this defense, I will show the how the paper-based SERS substrate manufacturing process can be modified to allow for the detection of hydrophobic analytes. Then, I will show how an alternative detection protocol can be applied to concentrate and measure larger volumes of hydrophobic analytes in an aqueous solution.
Gradient Methods with Memory
Creators: name: Nesterov, Yurii
name: Florea, Mihai I.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics
subject: 68Q25, 65Y20, 90C25

description: In this paper, we consider gradient methods for minimizing smooth convex functions, which employ the information obtained at the previous iterations in order to accelerate the convergence towards the optimal solution. This information is used in the form of a piece-wise linear model of the objective function, which provides us with much better prediction abilities as compared with the standard linear model. To the best of our knowledge, this approach was never really applied in Convex Minimization to differentiable functions in view of the high complexity of the corresponding auxiliary problems. However, we show that all necessary computations can be done very efficiently. Consequently, we get new optimization methods, which are better than the usual Gradient Methods both in the number of oracle calls and in the computational time. Our theoretical conclusions are confirmed by preliminary computational experiments.
description: This is an Accepted Manuscript of an article published by Taylor \& Francis in Optimization Methods and Software on 13 Jan 2021, available at https://www.tandfonline.com/doi/10.1080/10556788.2020.1858831
Conversion of Agro-industrial Wastes into Lipids
Suitable for Biodiesel Production
Creators: name: Abu, Yousuf
Publisher: name: Università degli Studi di Napoli Federico II
Year: 2010

description: Microorganisms that can accumulate lipids at more than 20% of their dry mass are defined as oleaginous species. The majority of these lipids are triacylglycerol containing long-chain fatty acids, which are comparable to conventional vegetable oils. The recent, increasing interest towards the oleaginous microorganisms is due to the potential use of microbial triglycerides as feedstock for biodiesel production.
The oleaginous yeasts used in this thesis work appear to be very promising, due to their versatility, as they allow the use of different kinds of residues as nutrients. In particular, Lipomyces starkeyi is so far one of the best used, as it has been proved to store large amounts of lipids.
Lipomyces starkeyi were first grown in the presence of olive oil mill wastewaters (OMW), a medium difficult to process by biological treatments, due to the antimicrobial activities of their phenolic components. We demonstrated that Lipomyces can produce, without external organic supplements, a significant reduction of both the total organic carbon (TOC) and the total phenols content, leading to a significant increase of the germination index. The fatty acid distribution showed a prevalence of oleic acid, demonstrating the potential of L. starkeyi as a source of lipids to be used as a feedstock for the synthesis of II generation biodiesel. The performance of Lipomyces was improved by a preliminary dilution of OMW.
Lipomyces were able to grow also in the presence of wastewaters from cheese factory, leading to a satisfactory growth and to a significant reduction of the TOC levels.
Cellulosic agricultural residues were also evaluated as feedstock for oleaginous yeasts. Lipomyces starkeyi were first grown in the hydrolysate of tomato wastes, containing mainly peel and seeds, at different nitrogen contents. The yeasts showed a favorable growth, with no need of addition of external nutrients.
Hydrolysates of Sorghum and Giant Reed were also studied as nutrients for the Lipomyces starkeyi. The conditions to maximize the lipid yield and the efficiency of the biomass conversion were found in terms of H2SO4 concentration (for the preliminary hydrolysis) and of medium composition (for the yeasts growth). Detoxification of hydrolysate with overlime and activated charcoal was carried out to reduce the concentration of microbial growth inhibitors, improving the growth of the yeasts in the undiluted hydrolysate.
In conclusion, the potential of oleaginous yeasts was demonstrated by the satisfactory microbial growth in the presence of different waste materials, and by the favorable composition of the triglycerides. Further studies are ongoing to optimize the preliminary hydrolysis of lignocellulosic materials and the lipid fraction of the yeasts.
A SPONTANEOUS MOUSE MODEL OF X-LINKED MYOPATHY WITH EXCESSIVE AUTOPHAGY
Creators: name: Iovane, Valentina
Publisher: name: Università degli Studi di Napoli Federico II
Year: 2011

description: the subject of the thesis research project, aims to characterize a murine model for spontaneous muscle pathology comparable to human "X-Linked Vacuolar myopathy with Excessive Autophagy (XMEA)". Along with Danon disease, these myopathies are characterized by the accumulation of vacuoles within the myofiber.
In 1988, Kalimo et al. have described five cases (all males) who had progressive proximal myopathy, which did not involve the heart muscle. The muscle biopsies of all patients showed numerous vacuoles, sarcoplasmic and subsarcolemmal, many of which were positive for the lysosomal enzyme, for the morphological appearance described, was proposed the term: X-Linked Vacuolar myopathy with Excessive Autophagy (XMEA).
We used crosses of strain C57/BL6 mice of different ages and sex, we processed triceps muscles, quadriceps femoris and the cranial tibial muscle and made morphological, histochemical and immunohistochemical staining on this samples. From laboratory tests performed on muscle biopsies, we found the presence of numerous vacuoles within muscle fibers, only in males. All these characters are comparable to XMEA.
The availability of a well characterized mouse model it may help define the etiopathogenesis of this disease.
Slides for: Twenty-Five Years of Advances in Beamforming: From Convex and Nonconvex Optimization to Learning Techniques
Creators: Kumar Vijay Mishra
Publisher: name: IEEE
Year: 2023

Slides for: SPS Webinar, July 7, 2023, Dr. Kumar Vijay Mishra
Beamforming is a signal processing technique to steer, shape, and focus an electromagnetic wave using an array of sensors toward a desired direction. It has been used in several engineering applications such as radar, sonar, acoustics, astronomy, seismology, medical imaging, and communications. With the advent of multi-antenna technologies in, say, radar and communication, there has been a great interest in designing beamformers by exploiting convex or nonconvex optimization methods. Recently, machine learning is also leveraged for obtaining attractive solutions to more complex beamforming scenarios. This webinar is the outcome of our recently published article in the 75th-anniversary special issue of the IEEE Signal Processing Magazine, wherein we capture the evolution of beamforming in the last twenty-five years from convex-to-nonconvex optimization and optimization-to-learning approaches. It provides a glimpse into these important signal processing algorithms for a variety of transmit-receive architectures, transmission zones, propagation paths, and multi-disciplinary applications.
Note: Joint work with Ahmet M. Elbir (University of Luxembourg), Sergiy A. Vorobyov (Aalto University), and Robert W. Heath, Jr. (North Carolina State University).
On-line Detection of Anomalies in Mission-critical Software Systems
Creators: name: Bovenzi, Antonio
Publisher: name: Università degli Studi di Napoli Federico II
Year: 2013

description: Revealing anomalies in  mission-critical software systems that make use of commercial off-the-shelf (OTS) for minimizing costs and time to market –e.g., power grids, transportation systems, financial services – is fundamental to avoid unexpected failures that may lead to loss of business or even may endanger our lives. Revealing anomalies by monitoring the operating environment in which OTS items are deployed is a promising approach when traditional detection mechanisms have poor performance or cannot be applied. Furthermore, the approach is particularly suited for OTS-based systems since it does not require to modify the application components.
This work investigated the effectiveness and efficiency of the OS-level anomaly detection approach, and contributed to the state-of-the art with a novel detection framework, i.e., sosmon, that relies on the following key characteristics: (i) the possibilities to deploy this mechanism on different OTS systems, working at the OS-level and, hence, without modifying the monitored application components; (ii) exploiting internal algorithms that make use of statistical observations on the monitored indicators to deal with non-stationary and variable operating conditions; (iii) the possibilities of tuning the framework according to the type of dependability requirements of the systems. The ability of the anomaly-detector framework to adapt its behavior to different working scenarios and its low intrusiveness, enriched by the encouraging results obtained in the experimental campaign, lays the ground towards practical deployment of sosmon in many real systems (varying from large scale complex and mission-critical OTS-based software systems to smaller and less critical systems), which have to deal with unreliable OTS components.
title: Journal Bildende Kunst.Gestaltung.Musik.Bühne.Wissen
Creators: name: Universität Der Künste Berlin
Publisher: name: Verlag der Universität der Künste Berlin
Year: 2023
Subjects: subject: 700 Künste; Bildende und angewandte Kunst

description: Ausgabe 23 (2023, Winter)
description: Journal Bildende Kunst.Gestaltung.Musik.Bühne.Wissen; 2023, Winter
Why Do Only Some Galaxy Clusters Have Cool Cores?
Creators: name: Burns, Jack O.
name: Hallman, Eric J.
name: Gantner, Brennan
name: Motl, Patrick M.
name: Norman, Michael L.
Publisher: name: arXiv
Year: 2007
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Flux-limited X-ray samples indicate that about half of rich galaxy clusters have cool cores. Why do only some clusters have cool cores while others do not? In this paper, cosmological N-body + Eulerian hydrodynamic simulations, including radiative cooling and heating, are used to address this question as we examine the formation and evolution of cool core (CC) and non-cool core (NCC) clusters. These adaptive mesh refinement simulations produce both CC and NCC clusters in the same volume. They have a peak resolution of 15.6 h^{-1} kpc within a (256 h^{-1} Mpc)^3 box. Our simulations suggest that there are important evolutionary differences between CC clusters and their NCC counterparts. Many of the numerical CC clusters accreted mass more slowly over time and grew enhanced cool cores via hierarchical mergers; when late major mergers occurred, the CC's survived the collisions. By contrast, NCC clusters experienced major mergers early in their evolution that destroyed embryonic cool cores and produced conditions that prevented CC re-formation. As a result, our simulations predict observationally testable distinctions in the properties of CC and NCC beyond the core regions in clusters. In particular, we find differences between CC versus NCC clusters in the shapes of X-ray surface brightness profiles, between the temperatures and hardness ratios beyond the cores, between the distribution of masses, and between their supercluster environs. It also appears that CC clusters are no closer to hydrostatic equilibrium than NCC clusters, an issue important for precision cosmology measurements.
description: 17 emulateapj pages, 17 figures, replaced with version accepted to ApJ
Slides for: Recent Advances in Integrated Sensing and Communications: Fundamental Limits, Signal Processing, and Prototyping
Creators: Fan Liu
Ya-Feng Liu
Christos Masouros
Publisher: name: IEEE
Year: 2023

Slides for: SPS Webinar, June 30, 2023, Dr. Fan Liu, Dr. Ya-Feng Liu,  Dr. Christos Masouros
In this talk, we shall present our recent research progress in the area of integrated sensing and communications, ISAC, which is envisioned as a key enabling technology towards next-generation wireless networks. Throughout this talk, the Cramer-Rao bound, CRB, is employed as a performance metric for sensing. We commence by characterizing the fundamental tradeoff between CRB and communication rate for generic ISAC systems that rely on unified waveforms. We then propose multi-input multi-output, MIMO, beamforming designs towards joint radar sensing and multi-user communications based on CRB minimization and provide numerical results to verify the effectiveness of the proposed design methodologies. Finally, we shall end this webinar by briefly introducing our recent efforts in developing proof-of-concept prototypes for ISAC systems.
ANALYSIS OF PHYSICAL AND MECHANICAL PROPERTIESOF LOCAL NATIONAL FABRICS.
Creators: name: Hojimatov, Rasuljon
Publisher: name: Zenodo
Year: 2023

description: The article examines the physical and mechanical properties of local fabrics used n the design of women’s ceremonial clothing and experimented at the Centexuz Certification Center under TTECI, identified and analyzed the physical and mechanical hygienic end other parameters of the samples.
Augmented Go & See: An approach for improved bottleneck identification in production lines
Creators: name: Hofmann, C.
name: Staehr, T.
name: Cohen, S.
name: Stricker, N.
name: Haefner, B.
name: Lanza, G.
Publisher: name: Karlsruhe
Year: 2019
Subjects: Mixed reality
Learning factory
bottlenecks

description: Bottlenecks in production lines are often shifting and thus hard to identify. They lead to decreased output, longer throughput times and higher work in progress. Go & See is a well-established Lean practice where managers go to the shop floor to see the problems first hand. Mixed reality is a promising technology to improve transparency in complex production environments. Until recently, mixed reality applications have been very demanding in terms of computing power requiring high performance hardware. This paper presents an approach for real-time KPI visualization using mixed reality for bottleneck identification in production lines relying on the bring-your-own device principle. The developed application uses image recognition to identify work stations and visualizes cycle times and work in progress in augmented reality. With this additional information, it is possible to discern different root causes for bottlenecks, for example systematically higher or varying cycle times due to breakdowns. This solution can be classified according to the acatech industry 4.0 maturity model as a level 3 - transparency - application. It could be shown that the identification of bottlenecks and underlying reasons has been improved compared to standard Go & See.
Impact of a positron beam at JLab on an unbiased determination of DVCS Compton Form Factors
Creators: name: Dutrieux, H.
name: Bertone, V.
name: Moutarde, H.
name: Sznajder, P.
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The impact of potential future measurements of beam charge asymmetries on the current knowledge of Compton form factors is evaluated. Elaborating on the results of a global neural network fit to deeply virtual Compton scattering data, a Bayesian reweighting analysis quantifies the improved determination of the real part of the Compton form factor $\mathcal{H}$. Such an improvement is particularly relevant for the experimental determination of the proton mechanical properties or for universality studies of generalized parton distributions through analyses of virtual Compton scattering in both spacelike and timelike regions.
description: 8 pages, 5 figures
Z', Z_KK, Z* and all that: current bounds and theoretical prejudices on heavy neutral vector bosons
Creators: name: Contino, Roberto
Publisher: name: arXiv
Year: 2008
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: I review the current experimental bounds and theoretical predictions for different kinds of heavy neutral vector bosons.
description: Talk given at: V Workshop Italiano sulla fisica p-p ad LHC, Perugia, Italy, 30 Jan. - 2 Feb. 2008
Exploring the interactional details between aldose reductase (AKR1B1) and 3-Mercapto-5H-1,2,4-triazino[5,6-b]indole-5-acetic acid through molecular dynamics simulations
Creators: name: Zhan, Jiu-Yu
name: Ma, Ke
name: Zheng, Qing-Chuan
name: Yang, Guang-Hui
name: Zhang, Hong-Xing
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Aldose reductase (AKR1B1) has been considered as a significant target for designing drugs to counteract the development of diabetic complications. In the present study, molecular dynamics (MD) simulations and molecular mechanics generalized Born surface area (MM-GB/SA) calculations were performed to make sure which tautomer is the preferred one among three tautomeric forms (Mtia1, Mtia2, and Mtia3) of 3-Mercapto-5H-1,2,4-triazino[5,6-b]indole-5-acetic acid (Mtia) for binding to AKR1B1. The overall structural features and the results of calculated binding free energies indicate that Mtia1 and Mtia2 have more superiority than Mtia3 in terms of binding to AKR1B1. Furtherly, the local active site conformational characteristics and non-covalent interaction analysis were identified. The results indicate that the combination of Mtia2 and AKR1B1 is more stable than that of Mtia1. Furthermore, two extra hydrogen bonds between AKR1B1 and Mtia2 are found with respect to Mtia1. In addition, Mtia2 makes slightly stronger electrostatic interaction with the positively charged nicotinamide group of NADP+ than Mtia1. Based on the results above, Mtia2 is the preferred tautomeric form among the three tautomers. Our study can provide an insight into the details of the interaction between AKR1B1 and Mtia at the atomic level, and will be helpful for the further design of AKR1B1 inhibitors.
Severe Acute Respiratory Syndrome Coronavirus-2 Breakthrough Infection Among Immunized Healthcare Workers
Creators: name: Zeenat Qureshi Stroke Institutes
Publisher: name: Zenodo
Year: 2023

description: Background— Data is currently evolving regarding incidence and prevalence of breakthrough infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in fully vaccinated healthcare workers (HCWs). In this study, we report upon four immunized HCWs who acquired SARS-CoV-2 infection and examine both their risk factors and disease progression.Methods— We identified four HCWs from single tertiary care hospital in Peshawar, Pakistan, who were immunized with the Sinopharm vaccine, and were subsequently diagnosed with a SARS-CoV-2 infection by polymerase chain reaction (PCR) test on nasopharyngeal specimen. We examined disease characteristics, duration between vaccine administration and breakthrough infection, and outcomes using a standardized questionnaire.Results— The mean duration between last dose of vaccine administration and breakthrough infection was 147.5 days ± standard deviation (SD) 16.3 days. The ages of HCWs were between 20-39 years and all 4 HCWs were men. Mean duration between the first and second dose of vaccine was 25 days ± standard deviation (SD) 7.1 days. All four vaccinated HCWs experienced fever, body aches, cough, nasal congestion, loss of smell and taste, and post infection fatigue and depression.Conclusions— Our study highlights the risk of SARS-CoV-2 breakthrough infection among fully vaccinated HCWs and necessity of booster immunization
Excited-state spectroscopy on a quantum dot side-coupled to a quantum wire
Creators: name: Otsuka, Tomohiro
name: Abe, Eisuke
name: Iye, Yasuhiro
name: Katsumoto, Shingo
Publisher: name: arXiv
Year: 2008
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We report excited-state spectroscopy on a quantum dot side-coupled to a quantum wire with accurate energy estimation. Our method utilizes periodic voltage pulses on the dot, and the energy calibration is performed with reference to the bias voltage across the wire. We demonstrate the observation of the orbital excited state and the Zeeman splitting in a single dot.
description: 3 pages, 4 figures
Ultracompact energy transfer in anapole-based metachains
Creators: name: Huang, T. C.
name: Wang, B. X.
name: Zhang, W. B.
name: Zhao, C. Y.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Optics (physics.optics)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: Realization of electromagnetic energy confinement beyond the diffraction limit is of paramount importance for novel applications like nano-imaging, information processing, and energy harvest. Current approaches based on surface plasmon polaritons and photonic crystals are either intrinsically lossy or with low coupling efficiency. Herein, we successfully address these challenges by constructing an array of nonradiative anapoles that originate from the destructive far-field interference of electric and toroidal dipole modes. The proposed metachain can achieve ultracompact (1/13 of incident wavelength) and high-efficiency electromagnetic energy transfer without the coupler. We experimentally investigate the proposed metachain at mid-infrared and give the first near-field experimental evidence of anapole-based energy transfer, in which the spatial profile of anapole mode is also unambiguously identified at nanoscale. We further demonstrate the metachain is intrinsically lossless and scalable at infrared wavelengths, realizing a 90$^\circ$ bending loss down to 0.32 dB at the optical communication wavelength. The present scheme bridges the gap between the energy confinement and transfer of anapoles, and opens a new gate for more compactly integrated photonic and energy devices, which can operate in a broad spectral range.
description: 10 pages, 6 figures, comments are welcome. Supplementary materials are available upon request