MOESM1 of Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk: an international prospective cohort of BRCA1 and BRCA2 mutation carriers
Creators: name: Mavaddat, Nasim
name: Antoniou, Antonis
name: Mooij, Thea
name: Hooning, Maartje
name: Heemskerk-Gerritsen, Bernadette
name: Noguès, Catherine
name: Gauthier-Villars, Marion
name: Caron, Olivier
name: Gesta, Paul
name: Pujol, Pascal
name: Lortholary, Alain
name: Barrowdale, Daniel
name: Frost, Debra
name: D. Evans
name: Izatt, Louise
name: Adlard, Julian
name: Eeles, Ros
name: Brewer, Carole
name: Tischkowitz, Marc
name: Henderson, Alex
name: Cook, Jackie
name: Eccles, Diana
name: Engelen, Klaartje
name: Mourits, Marian
name: Ausems, Margreet
name: Linetta Koppert
name: Hopper, John
name: John, Esther
name: Chung, Wendy
name: Andrulis, Irene
name: Daly, Mary
name: Buys, Saundra
name: Benitez, Javier
name: Caldes, Trinidad
name: Jakubowska, Anna
name: Simard, Jacques
name: Singer, Christian
name: Tan, Yen
name: Olah, Edith
name: Navratilova, Marie
name: Foretova, Lenka
name: Gerdes, Anne-Marie
name: Marie-José Roos-Blom
name: Leeuwen, Flora
name: Arver, Brita
name: Olsson, Håkan
name: Schmutzler, Rita
name: Engel, Christoph
name: Kast, Karin
name: Kelly-Anne Phillips
name: Terry, Mary
name: Milne, Roger
name: Goldgar, David
name: Rookus, Matti
name: Andrieu, Nadine
name: Easton, Douglas
Publisher: name: figshare
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Inorganic Chemistry
subject: Plant Biology
subject: Computational Biology

description: Additional file 1 : Table S1. Studies and samples included in the prospective cohort of BRCA1 and BRCA2 mutation carriers. Table S2. Distributions of dates of breast cancer diagnosis, DNA test and start of follow-up in the prospective cohort. Table S3. Characteristics of reported Risk-Reducing Salpingo-oophorectomy. Table S4. Characteristics of cohort of BRCA1 and BRCA2 mutation carriers. Table S5. Association between RRSO and breast cancer by menopausal status. Table S6. Association between RRSO and breast cancer (sensitivity analysis with RRSO status changing at the age at the questionnaire with information on RRSO status changes (all studies except HEBON)). Table S7. Association between RRSO and breast cancer (sensitivity analysis dropping individuals with missing information at baseline). Table S8. Association between RRSO and breast cancer among BRCA1 and BRCA2 mutation carriers (sensitivity analysis excluding women with RRSO before baseline). Table S9. Association between family history of breast cancer and family history of ovarian cancer and RRSO uptake. Table S10. Association between parity, age at first birth, and body mass index and RRSO uptake. Table S11. Association between RRSO and breast cancer adjusting for Body Mass Index, family history of breast cancer, family history of ovarian cancer, parity and age at first birth. Table S12. Hormone replacement therapy use among women in the cohort. Table S13. Association between RRSO and breast cancer among women not exposed to hormone replacement therapy. Table S14. Association between RRSO and breast cancer (excluding kConFab/BCFR). Table S15. Association between natural menopause and breast cancer (censoring at RRSO). Ethics Committee Approvals