cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Biology, Metastatic Patterns, and Treatment of Patients with Triple-Negative Breast Cancer
Creators: name: Anders, Carey K.
name: Carey, Lisa A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Of the estimated 1 million cases of breast cancer diagnosed annually worldwide, it is estimated that over 170,000 will harbor the triple-negative (estrogen receptor/progesterone receptor/HER2–negative) phenotype. Most, though not all, triple-negative breast cancers will be basal-like on gene expression micorarrays. The basal-like molecular subtype exhibits a unique molecular profile and set of risk factors, aggressive and early pattern of metastasis, limited treatment options, and poor prognosis. Large population-based studies have identified a higher proportion of triple-negative breast tumors among premenopausal African American women, and a suggestion that increased parity, younger age at first-term pregnancy, shorter duration of breast feeding, and elevated hip-to-waist ratio might be particular risk factors. When BRCA1 mutation carriers develop breast cancer, it is usually basal-like; given the central role of BRCA1 in DNA repair, this could have profound therapeutic implications. When diagnosed, triple-negative breast cancers illustrate preferential relapse in visceral organs, including the central nervous system. Although initial response to chemotherapy might be more profound, relapse is early and common among triple-negative breast cancers compared with luminal breast cancers. The armamentarium of “targeted therapeutics” for triple-negative breast cancer is evolving and includes strategies to inhibit angiogenesis, epidermal growth factor receptor, and other kinases. Finally, the positive association between triple-negative breast cancer and BRCA mutations makes inhibition of poly(adenosine diphosphate-ribose) polymerase–1 an attractive therapeutic strategy that is in active study.
Phase II Study of Bortezomib and Pegylated Liposomal Doxorubicin in the Treatment of Metastatic Breast Cancer
Creators: name: Perou, Charles
name: Collichio, Frances A.
name: Bernard, Philip S.
name: Orlowski, Robert Z.
name: Stijleman, Inge J.
name: Ivanova, Anastasia
name: Chiu, Wing Keung
name: Dees, E. Claire
name: Carey, Lisa A.
name: Irvin Jr., William J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Based on preclinical studies and a phase I trial of the combination of bortezomib and pegylated liposomal doxorubicin (PLD), which both showed activity in breast cancer, we conducted a phase II study of this regimen in patients with metastatic breast cancer.
title: Demyelinating diseases differential diagnosis: Looking beyond the Multiple Sclerosis (MS)
Creators: name: Guia Yerovi, Cyndy Suzette
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Neuroradiology brain
subject: MR
subject: MR-Diffusion/Perfusion
subject: Education
subject: Inflammation
subject: Ischaemia / Infarction

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Know the main diseases included in the differential diagnosis of multiple sclerosis (MS) and their characteristics. Identify the general and key radiology features that make one entity different from...
COVID-19: From epidemiology to treatment
Creators: name: Sheahan, T.P.
name: Falces, C.
name: Pericàs, J.M.
name: Miro, J.M.
name: Marcos, M.A.
name: Tuset, M.
name: Vilella, A.
name: Quintana, E.
name: Ambrosioni, J.
name: Hospital Clinic Cardiovascular Infections Study Group
name: Hernandez-Meneses, M.
name: Moreno, A.
name: Sandoval, E.
Publisher: name: Oxford University Press
Year: 2020

description: The COVID-19 pandemic has greatly impacted the daily clinical practice of cardiologists and cardiovascular surgeons. Preparedness of health workers and health services is crucial to tackle the enormous challenge posed by SARS-CoV-2 in wards, operating theatres, intensive care units, and interventionist laboratories. This Clinical Review provides an overview of COVID-19 and focuses on relevant aspects on prevention and management for specialists within the cardiovascular field.
(401282) James Anderson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Vector meson spectral function and dilepton rate in the presence of strong entanglement effect between the chiral and the Polyakov loop dynamics
Creators: name: Islam, Chowdhury Aminul
name: Majumder, Sarbani
name: Mustafa, Munshi G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: In this work we have re-explored our earlier study on the vector meson spectral function and its spectral property in the form of dilepton rate in a two-flavour Polyakov loop extended Nambu-Jona-Lasinio (PNJL) model in presence of a strong entanglement between the chiral and Polyakov loop dynamics. The entanglement considered here is generated through the four-quark scalar type interaction in which the coupling strength depends on the Polyakov loop and runs with temperature and chemical potential. The entanglement effect is also considered for the four-quark vector type interaction in the same manner. We observe that the entanglement effect relatively enhances the color degrees of freedom due to the running of the both scalar and vector couplings. This modifies the vector meson spectral function and thus the spectral property such as the dilepton production rate in low invariant mass also gets modified.
description: 12 Pages, 18 figures
A magnetic topological semimetal Sr1-yMn1-zSb2 (y, z< 0.1)
Creators: name: Liu, J. Y.
name: Hu, J.
name: Zhang, Q.
name: Graf, D.
name: Cao, H. B.
name: Radmanesh, S. M. A.
name: Adams, D. J.
name: Zhu, Y. L.
name: Cheng, G. F.
name: Liu, X.
name: Phelan, W. A.
name: Wei, J.
name: Tennant, D. A.
name: DiTusa, J. F.
name: Chiorescu, I.
name: Spinu, L.
name: Mao, Z. Q.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Weyl (WSMs) evolve from Dirac semimetals in the presence of broken time-reversal symmetry (TRS) or space-inversion symmetry. The WSM phases in TaAs-class materials and photonic crystals are due to the loss of space-inversion symmetry. For TRS-breaking WSMs, despite numerous theoretical and experimental efforts, few examples have been reported. In this Article, we report a new type of magnetic semimetal Sr1-yMn1-zSb2 (y,z<0.1) with nearly massless relativistic fermion behaviour (m*=0.04-0.05m0, where m0 is the free electron mass). This material exhibits a ferromagnetic order for 304K < T < 565K, but a canted antiferromagnetic order with a ferromagnetic component for T < 304K. The combination of relativistic fermion behaviour and ferromagnetism in Sr1-yMn1-zSb2 offers a rare opportunity to investigate the interplay between relativistic fermions and spontaneous TRS breaking.
description: Accepted by Nature Materials
A Phase II Study of Sagopilone (ZK 219477; ZK-EPO) in Patients With Breast Cancer and Brain Metastases
Creators: name: Harris, Gordon
name: Sun, Lixian
name: Winer, Eric P.
name: Freedman, Rachel A.
name: Bullitt, Elizabeth
name: Lin, Nancy U.
name: Krop, Ian E.
name: Partridge, Ann H.
name: Gelman, Rebecca
name: Eisenberg, Emily
name: Ligibel, Jennifer A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Treatments for women with recurrent brain metastases from breast cancer are limited. In this phase II study, we administered sagopilone to patients with breast cancer and brain metastases. We observed modest activity with a central nervous system objective response rate of 13.3%; however, median PFS was disappointing. Further studies should focus on other agents to treat this challenging clinical problem.
Inventar der als Stiftung Karl Geigy-Hagenbach der Universitätsbibliothek Basel übergebenen Autographen-Sammlung
Creators: name: Burckhardt, Max
Publisher: name: [Universitätsbibliothek]
Year: 1960
Subjects: Geigy-Hagenbach, Karl1866-1949Carl AlphonsGeigy

description: Geordnet nach Nummern des von K. Geigy-Hagenbach 1929 veröffentlichten Katalogs mit Anhang der im Katalog nicht verzeichneten Stücke
description: [erstellt von Max Burckhardt]
description: Typoskript
(401283) Janet Lownie
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Quantum-Gravity Fluctuations and the Black-Hole Temperature
Creators: name: Hod, Shahar
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Bekenstein has put forward the idea that, in a quantum theory of gravity, a black hole should have a discrete energy spectrum with concomitant discrete line emission. The quantized black-hole radiation spectrum is expected to be very different from Hawking's semi-classical prediction of a thermal black-hole radiation spectrum. One naturally wonders: Is it possible to reconcile the {\it discrete} quantum spectrum suggested by Bekenstein with the {\it continuous} semi-classical spectrum suggested by Hawking ? In order to address this fundamental question, in this essay we shall consider the zero-point quantum-gravity fluctuations of the black-hole spacetime. In a quantum theory of gravity, these spacetime fluctuations are closely related to the characteristic gravitational resonances of the corresponding black-hole spacetime. Assuming that the energy of the black-hole radiation stems from these zero-point quantum-gravity fluctuations of the black-hole spacetime, we derive the effective temperature of the quantized black-hole radiation spectrum. Remarkably, it is shown that this characteristic temperature of the {\it discrete} (quantized) black-hole radiation agrees with the well-known Hawking temperature of the {\it continuous} (semi-classical) black-hole spectrum.
description: 6 pages
Focal Adhesion Kinase Silencing Augments Docetaxel-Mediated Apoptosis in Ovarian Cancer Cells
Creators: name: Schmandt, Rosemarie
name: Nelkin, Gina M.
name: Fan, Dominic
name: Sood, Anil K.
name: Schaller, Michael D.
name: Jennings, Nicholas B.
name: Landen Jr., Charles N.
name: Halder, Jyotsnabaran
name: Lutgendorf, Susan K.
name: Li, Yang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Docetaxel causes cell death through induction of apoptosis; however, cell death characteristics for docetaxel have not yet been fully elucidated. We examined the role of focal adhesion kinase (FAK) cleavage in docetaxel-mediated apoptosis.
(401279) Beatrice Buik Webster
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Evaluation of predictive markers for the efficacy of Hepatic Infusion Therapy of liver metastases in palliative care
Creators: name: Milosevic, Aleksandar
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Interventional non-vascular
subject: Interventional vascular
subject: Oncology
subject: CT
subject: Fluoroscopy
subject: Chemotherapy
subject: Laboratory tests
subject: Treatment effects
subject: Cancer
subject: Metastases

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Hepatic Arterial Infusion Chemotherapy (HAIC) remains to this date a valuable asset in salvage therapy concepts. HAIC has been used successfully for years in palliative cancer care and, thanks to new therapeutic regimes, has increasingly moved...
Effects of a Topically Applied Bioadhesive Berry Gel on Loss of Heterozygosity Indices in Premalignant Oral Lesions
Creators: name: Shumway, Brian S.
name: Mallery, Susan R.
name: Stoner, Gary D.
name: Mumper, Russell J.
name: Lu, Bo
name: Kresty, Laura A.
name: Fields, Henry W.
name: Zwick, Jared C.
name: Larsen, Peter E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The aim of this study was to assess the effects of topical application of a 10% (w/w) freeze-dried black raspberry (FBR) gel on oral intraepithelial neoplasia (IEN) variables that included histologic diagnoses and loss of heterozygosity (LOH) indices. Microsatellite instability and/or LOH at tumor suppressor gene – associated chromosomal loci have been associated with a higher risk for oral IEN progression to oral squamous cell carcinoma. Previously, our laboratories have shown that FBRs are well tolerated and possess potent antioxidant, apoptotic, and differentiation-inducing properties.
Katalog der Autographen Geigy-Hagenbach : Nachtrag 1960
Autographen-Sammlung Geigy-Hagenbach
Creators: name: Burckhardt, Max
Publisher: name: [Universitätsbibliothek]
Year: 1939
Subjects: Geigy-Hagenbach, Karl1866-1949Carl AlphonsGeigy

description: [erstellt von Max Burckhardt]
description: Typoskript
Inhibition of the p53 E3 Ligase HDM-2 Induces Apoptosis and DNA Damage-Independent p53 Phosphorylation in Mantle Cell Lymphoma
Creators: name: Orlowski, Robert Z.
name: Jones, Richard J.
name: Bruey-Sedano, Nathalie
name: Young, Ken H.
name: Yang, Dajun
name: Chen, Qing
name: Voorhees, Peter
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The ubiquitin-proteasome pathway has been validated as a target in non-Hodgkin lymphoma through demonstration of the activity of the proteasome inhibitor bortezomib.
Proper $G_a$-actions on $\C^4$ preserving a coordinate
Creators: name: Kaliman, Shulim
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14R20, 14L30, 32M17

description: We prove that the actions mentioned in the title are translations. We show also that for certain $G_a$-actions on affine fourfolds the quotient of the action is automatically affine and describe the geometric structure of such quotients.
description: 34 page
Plasma Insulin-like Growth Factors, Insulin-like Binding Protein-3, and Outcome in Metastatic Colorectal Cancer: Results from Intergroup Trial N9741
Creators: name: Fuchs, Charles S.
name: Meyerhardt, Jeffrey A.
name: Green, Erin M.
name: Sargent, Daniel J.
name: Wolpin, Brian M.
name: Pollak, Michael
name: Pitot, Henry C.
name: Goldberg, Richard M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Insulin-like growth factor (IGF)-I and IGF-II stimulate neoplastic cell growth and inhibit apoptosis, whereas IGF-binding protein-3 (IGFBP-3) inhibits the bioavailability of IGF-I and has independent proapoptotic activity. We examined the influence of baseline plasma levels of IGF-I, IGF-II, IGFBP-3, and C-peptide on outcome among patients receiving first-line chemotherapy for metastatic colorectal cancer.
Prognostic Significance of Defective Mismatch Repair and BRAF V600E in Patients with Colon Cancer
Creators: name: Burgart, Lawrence J.
name: Shepherd, Lois
name: French, Amy J.
name: Kabat, Brian F.
name: Windschitl, Harold E.
name: Thibodeau, Stephen N.
name: Foster, Nathan R.
name: Goldberg, Richard
name: Sargent, Daniel J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Colon tumors with defective DNA mismatch repair (dMMR) have a well characterized phenotype and accounts for ~15–20% of sporadic colon cancer (CC) as well as those colon cancer patients with Lynch Syndrome. Although the presence of dMMR appears to be a favorable prognostic marker, data suggests that these patients do not respond as well to adjuvant chemotherapy.
title: Ultrasound findings in ductal carcinoma in situ of the breast: A pictorial review.
Creators: name: Sotomayor, Camilo G.
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Breast
subject: Mammography
subject: Ultrasound
subject: Education
subject: Cancer
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Show the main ultrasound findings of ductal carcinoma in situ of the breast (DCIS) of cases diagnosed in our...
title: COVID-19 pandemic: Occupational and emotional impact on a radiology and diagnostic imaging service in Colombia
Creators: name: Sisa Rodríguez, Jason
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Professional issues
subject: Radiographers
subject: Experimental
subject: Education
subject: Health policy and practice
subject: Education and training
subject: Occupational / Environmental hazards

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: The COVID 19 pandemic has generated significant changes in the provision of health services in the world [1]. Radiology services have been playing an important role in this restructuring, leading to an increase in workload, stress due to prolonged...
(401280) Bella [Anabel] Lizzie Lyon Robertson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Validation of Analytic Methods for Biomarkers Used in Drug Development
Creators: name: Chau, Cindy H.
name: McLeod, Howard
name: Rixe, Olivier
name: Figg, William D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The role of biomarkers in drug discovery and development has gained precedence over the years. As biomarkers become integrated into drug development and clinical trials, quality assurance and in particular assay validation becomes essential with the need to establish standardized guidelines for analytical methods used in biomarker measurements. New biomarkers can revolutionize both the development and use of therapeutics, but is contingent upon the establishment of a concrete validation process that addresses technology integration and method validation as well as regulatory pathways for efficient biomarker development. This perspective focuses on the general principles of the biomarker validation process with an emphasis on assay validation and the collaborative efforts undertaken by various sectors to promote the standardization of this procedure for efficient biomarker development.
Indirect determinations of the top quark mass
Creators: name: Giudice, Gian F.
name: Paradisi, Paride
name: Strumia, Alessandro
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We give a complete analysis of indirect determinations of the top quark mass in the Standard Model by introducing a systematic procedure to identify observables that receive quantum corrections enhanced by powers of $M_t$. We propose to use flavour physics as a tool to extract the top quark mass. Although present data give only a poor determination, we show how future theoretical and experimental progress in flavour physics can lead to an accuracy in $M_t$ well below 2 GeV. We revisit determinations of $M_t$ from electroweak data, showing how an improved measurement of the $W$ mass leads to an accuracy well below 1 GeV.
description: 31 pages, 6 figures. v2: final version to appear on JHEP
(401281) David Lyon Robertson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
14-3-3  Amplifies Androgen Receptor Actions in Prostate Cancer
Creators: name: Mohler, James L.
name: French, Frank S.
name: Wilson, Elizabeth M.
name: Tan, Jiann An
name: Gregory, Christopher W.
name: Subramanian, Romesh R.
name: Fu, Haian
name: Ford, O. Harris
name: Titus, Mark A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Androgen receptor (AR) abundance and AR-regulated gene expression in castration-recurrent prostate cancer (CaP) are indicative of AR activation in the absence of testicular androgen. AR transactivation of target genes in castration-recurrent CaP occurs in part through mitogen signaling that amplifies the actions of AR and its coregulators. Herein we report on the role of 14-3-3η in AR action.
title: The Traveler’s Journey: nodal dissemination of pelvic neoplasms.
Creators: name: Ramirez, Diego
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Genital / Reproductive system female
subject: Genital / Reproductive system male
subject: Lymph nodes
subject: CT
subject: MR-Diffusion/Perfusion
subject: PET-CT
subject: Education
subject: Staging
subject: Cancer

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Know the anatomy and nomenclature of the lymph nodes (LN) groups. Evaluate the patterns of lymphatic spread of the main pelvic neoplasms, in computed tomography (CT), positron emission tomography - computed tomography (PET-CT) and magnetic resonance...
A Multi-Institutional Phase II Study of the Efficacy and Tolerability of Lapatinib in Patients with Advanced Hepatocellular Carcinomas
Creators: name: Lee, Ruey Min
name: Balint, Catherine
name: Zalupski, Mark
name: Villalona-Calero, Miguel
name: O'Neil, Bert
name: Heerema, Nyla
name: Bekaii-Saab, Tanios
name: Chen, Helen
name: Dai, Zunyan
name: Wei, Lai
name: Sadee, Wolfgang
name: Campbell, Angela
name: Papp, Audrey
name: Markowitz, Joseph
name: Eng, Charis
name: Culler, Kristy
name: Grever, Michael
name: Prescott, Nichole
name: Dancey, Janet
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Hepatocellular carcinoma (HCC) is on the rise worldwide. HCC responds poorly to chemotherapy. Lapatinib is an inhibitor of EGFR and HER2/NEU both implicated in hepatocarcinogenesis. This trial was designed to determine the safety and efficacy of lapatinib in HCC.
(401277) John George Lyon Webster
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Beyond bronchial arteries: Other causes of hemoptysis
Creators: name: Abello Jofre, Myriam Lorena
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Anatomy
subject: Pulmonary vessels
subject: Thorax
subject: CT-Angiography
subject: Education
subject: Acute
subject: Cavitation
subject: Hyperplasia / Hypertrophy

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Explain the suitable CT protocol when assisting patients with hemoptysis. Illustrate the radiological anatomy of bronchial arteries. Describe the CT findings and pathophysiological mechanisms of various causes of...
Fermionic extensions of the Standard Model in light of the Higgs couplings
Creators: name: Bizot, Nicolas
name: Frigerio, Michele
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: As the Higgs boson properties settle, the constraints on the Standard Model extensions tighten. We consider all possible new fermions that can couple to the Higgs, inspecting sets of up to four chiral multiplets. We confront them with direct collider searches, electroweak precision tests, and current knowledge of the Higgs couplings. The focus is on scenarios that may depart from the decoupling limit of very large masses and vanishing mixing, as they offer the best prospects for detection. We identify exotic chiral families that may receive a mass from the Higgs only, still in agreement with the $hγγ$ signal strength. A mixing $θ$ between the Standard Model and non-chiral fermions induces order $θ^2$ deviations in the Higgs couplings. The mixing can be as large as $θ\sim 0.5$ in case of custodial protection of the $Z$ couplings or accidental cancellation in the oblique parameters. We also notice some intriguing effects for much smaller values of $θ$, especially in the lepton sector. Our survey includes a number of unconventional pairs of vector-like and Majorana fermions coupled through the Higgs, that may induce order one corrections to the Higgs radiative couplings. We single out the regions of parameters where $hγγ$ and $hgg$ are unaffected, while the $hγZ$ signal strength is significantly modified, turning a few times larger than in the Standard Model in two cases. The second run of the LHC will effectively test most of these scenarios.
description: v2: a few clarifications and references added, improved treatment of the constraint from Z-b-bbar, Higgs couplings updated by using the combined ATLAS+CMS fit
Activation of Host Wound Responses in Breast Cancer Microenvironment
Creators: name: Schneider, Sallie Smith
name: Joseph Jerry, D.
name: Troester, Melissa A.
name: Pirone, Jason R.
name: Carter, Matthew
name: Fan, Cheng
name: Lee, Myung Hee
name: Perou, Charles M.
name: Cowan, David W.
name: Perez, Erick Roman
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Cancer progression is mediated by processes that are also important in wound repair. As a result, cancers have been conceptualized as overhealing wounds or wounds that do not heal, and gene expression signatures reflective of wound repair have shown value as predictors of breast cancer survival. Despite the widespread acknowledgment of commonalities between host responses to wounds and host responses to cancer, the gene expression responses of normal tissue adjacent to cancers have not been well characterized. Using RNA extracted from histologically normal breast tissue from 107 patients, including 60 reduction mammoplasty patients and 47 cancer patients, we measured whole genome expression profiles and identified a gene expression signature that is induced in response to breast cancer. This signature represents an in vivo wound response signature that is differentially expressed in the normal tissue of breast cancer patients compared to those without disease and is highly accurate (at least 92% sensitivity and 98% specificity) in distinguishing diseased and nondiseased. The in vivo wound response signature is highly prognostic of breast cancer survival and there is a strong association between the groups identified by this signature and those identified using serum-treated fibroblasts and other microenvironment-derived or -related signatures. The prevalence of the wound response signature in histologically normal tissue adjacent to breast cancer suggests that microenvironment response is an important variable in breast cancer progression and may be an important target for clinical interventions.
KRAS Mutation in Stage III Colon Cancer and Clinical Outcome Following Intergroup Trial CALGB 89803
Creators: name: Niedzwiecki, Donna
name: Mayer, Robert J.
name: Hantel, Alexander
name: Ogino, Shuji
name: Saltz, Leonard B.
name: Meyerhardt, Jeffrey A.
name: Goldberg, Richard M.
name: Benson III, Al B.
name: Schaefer, Paul
name: Irahara, Natsumi
name: Hollis, Donna
name: Whittom, Renaud
name: Bertagnolli, Monica M.
name: Fuchs, Charles S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Alterations in the RAS and RAF pathway relate to epigenetic and epigenomic aberrations, and are important in colorectal carcinogenesis. KRAS mutation in metastatic colorectal cancer predicts resistance to anti-EGFR targeted therapy (cetuximab or panitumumab). However, it remains uncertain whether KRAS mutation predicts prognosis or clinical outcome of colon cancer patients independent of anti-EGFR therapy.
title: Rectal cancer management after neoadjuvant therapy: a review of the pivotal role of MRI
Creators: name: Santos, Sofia
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Gastrointestinal tract
subject: Management
subject: Oncology
subject: MR
subject: Comparative studies
subject: Cancer
subject: Multidisciplinary cancer care

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To elucidate the role of magnetic resonance imaging (MRI) in patients with rectal cancer, after neoadjuvant chemoradiotherapy. To illustrate MRI findings in the post-chemoradiotherapy setting, including how to identify signs of complete response and...
p27Kip1 in Stage III Colon Cancer: Implications for Outcome following Adjuvant Chemotherapy in Cancer and Leukemia Group B Protocol 89803
Creators: name: Jewell, Scott D.
name: Redston, Mark
name: Loda, Massimo
name: Saltz, Leonard B.
name: Bertagnolli, Monica M.
name: Hall, Margaret
name: Niedzwiecki, Donna
name: Mueller, Elke
name: Hahn, Hejin P.
name: Compton, Carolyn C.
name: S.Warren, Robert
name: Mayer, Robert J.
name: Goldberg, Richard M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: In retrospective studies, loss of p27Kip1 (p27), a cyclin dependent kinase inhibitor, has been associated with poor prognosis following colorectal cancer treatment. In a prospective study, we validated this relationship in patients enrolled on a trial of adjuvant chemotherapy for Stage III colon cancer.
Lattice study on QCD-like theory with exact center symmetry
Creators: name: Iritani, Takumi
name: Itou, Etsuko
name: Misumi, Tatsuhiro
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We investigate QCD-like theory with exact center symmetry, with emphasis on the finite-temperature phase transition concerning center and chiral symmetries. On the lattice, we formulate center symmetric $SU(3)$ gauge theory with three fundamental Wilson quarks by twisting quark boundary conditions in a compact direction ($Z_3$-QCD model). We calculate the expectation value of Polyakov loop and the chiral condensate as a function of temperature on 16^3 x 4 and 20^3 x 4 lattices along the line of constant physics realizing $m_{PS}/m_{V}=0.70$. We find out the first-order center phase transition, where the hysteresis of the magnitude of Polyakov loop exists depending on thermalization processes. We show that chiral condensate decreases around the critical temperature in a similar way to that of the standard three-flavor QCD, as it has the hysteresis in the same range as that of Polyakov loop. We also show that the flavor symmetry breaking due to the twisted boundary condition gets qualitatively manifest in the high-temperature phase. These results are consistent with the predictions based on the chiral effective model in the literature. Our approach could provide novel insights to the nonperturbative connection between the center and chiral properties.
description: 25 pages, 6 figures, to apper in JHEP
Phase I and Pharmacokinetic Study of Pegylated Liposomal CKD-602 in Patients with Advanced Malignancies
Creators: name: Ramalingam, Suresh
name: Stoller, Ronald G.
name: Maruca, Lauren
name: Belani, Chandra P.
name: Friedland, David M.
name: Ramanathan, Ramesh K.
name: Zamboni, Beth A.
name: Strychor, Sandra
name: Zamboni, William C.
name: Edwards, Robert P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: S-CKD602 is a pegylated liposomal formulation of CKD-602, a semi-synthetic camptothecin analogue. Pegylated (STEALTH®) liposomes can achieve extended drug exposure in plasma and tumor. Based on promising preclinical data, the first phase I study of S-CKD602 was performed in patients (pts) with refractory solid tumors.
Morita Equivalence and Spectral Triples on Noncommutative Orbifolds
Creators: name: Harju, Antti J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: Mathematical Physics (math-ph)
subject: Operator Algebras (math.OA)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: Let $G$ be a finite group. Noncommutative geometry of unital $G$-algebras is studied. A geometric structure is determined by a spectral triple on the crossed product algebra associated with the group action. This structure is to be viewed as a representative of a noncommutative orbifold. Based on a study of classical orbifold groupoids, a Morita equivalence for the crossed product spectral triples is developed. Noncommutative orbifolds are Morita equivalence classes of the crossed product spectral triples. As a special case of this Morita theory one can study freeness of the $G$-action on the noncommutative level. In the case of a free action, the crossed product formalism reduced to the usual spectral triple formalism on the algebra of $G$-invariant functions.
(401278) Elizabeth Stenhouse Webster
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: The CT findings of abdominal anticoagulant-related hematomas
Creators: name: Saldanha, Gonçalo
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Emergency
subject: CT
subject: Complications
subject: Diagnostic procedure
subject: Haemorrhage

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Explain the Computed Tomography (CT) study protocol in case of suspected abdominal hematoma; Review and illustrate the main CT image findings of anticoagulant therapy-induced abdominal hematomas; Increase radiologists’ awareness of these findings,...
Philodemus, Index Academicorum, edited by Kilian J. Fleischer
Creators: name: Fleischer, Kilian J.
Publisher: name: Zenodo
Year: 2023
Subjects: subject: Digital Humanities
subject: Digital Papyrology
subject: Computational Philology
subject: Classics
subject: Philosophy (ancient philosophy)
subject: Papyrology
subject: Ancient history epigraphy
subject: Archaeology
subject: Literary Studies
subject: FOS: Languages and literature

description: Philodemus’ History of the Academy represents a valuable treatise on Greek philosophical schools containing much unique information on Plato and on the development of the Academy under his successors. The so called Index Academicorum is a draft version preserved in a Herculaneum papyrus, which has been reread and reedited on the basis of innovative papyrological criteria and pioneering imaging techniques. The text is now very different from former editions and reveals countless new facts on various Academic philosophers. The edition provides new insights of interdisciplinary relevance into ancient philosophy, biography, literature and the ancient process of writing a book.
Intrinsic Breast Tumor Subtypes, Race, and Long-Term Survival in the Carolina Breast Cancer Study
Creators: name: Cole, Stephen R.
name: Millikan, Robert C.
name: O'Brien, Katie M.
name: Geradts, Joseph
name: Foulkes, William D.
name: Carey, Lisa A.
name: Tse, Chiu Kit
name: Perou, Charles M.
name: Dressler, Lynn G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Previous research identified differences in breast cancer-specific mortality across four "intrinsic" tumor subtypes: luminal A, luminal B, basal-like, and human epidermal growth factor receptor 2 positive/estrogen receptor negative (HER2+/ER−).
(401274) Thomas Ewan
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Lung Squamous Cell Carcinoma mRNA Expression Subtypes Are Reproducible, Clinically Important, and Correspond to Normal Cell Types
Creators: name: Liu, Yufeng
name: Bernard, Philip S.
name: Parsons, Alden M.
name: Muldrew, Kenneth
name: Thorne, Leigh
name: Socinski, Mark A.
name: Perou, Charles M.
name: Randell, Scott H.
name: Miller, C. Ryan
name: Hayward, Michele C.
name: Wilkerson, Matthew D.
name: Roberts, Patrick J.
name: Hayes, D. Neil
name: Lee, Carrie B.
name: Hoadley, Katherine A.
name: Yin, Xiaoying
name: Funkhouser, William K.
name: Cabanski, Christopher R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Lung squamous cell carcinoma (SCC) is clinically and genetically heterogeneous and current diagnostic practices do not adequately substratify this heterogeneity. A robust, biologically-based SCC subclassification may describe this variability and lead to more precise patient prognosis and management. We sought to determine if SCC mRNA expression subtypes exist, are reproducible across multiple patient cohorts, and are clinically relevant.
title: Respiratory distress in newborns: what the radiologist needs to know.
Creators: name: EL OUALLADI, Feryal
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Emergency
subject: Lung
subject: Paediatric
subject: Conventional radiography
subject: CT
subject: eLearning
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: - To specify the main causes of neonatal respiratory distress.- To illustrate their radiological aspects.- To highlight the limits and contribution of different imaging techniques in their...
Poly(ADP-Ribose) Polymerase Inhibition: "Targeted" Therapy for Triple-Negative Breast Cancer
Creators: name: Anders, Carey K.
name: Ford, James M.
name: Dent, Rebecca
name: Sledge, George W.
name: Silver, Daniel P.
name: Winer, Eric P.
name: Carey, Lisa A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: In contrast to endocrine-sensitive and HER2-positive breast cancer, novel agents capable of treating advanced triple negative breast cancer (TNBC) are lacking. PARP (Poly-(adenosine diphosphate [ADP]-ribose) polymerase) inhibitors are emerging as one of the most promising ‘targeted’ therapeutics to treat TNBC, with the intended ‘target’ being DNA repair. PARP's are a family of enzymes involved in multiple cellular processes including DNA repair. TNBC shares multiple clinico-pathologic features with BRCA-mutated breast cancers which harbor dysfunctional DNA repair mechanisms. Investigators hypothesized PARP inhibition, in conjunction with the loss of DNA-repair via BRCA-dependent mechanisms, would result in synthetic lethality and augmented cell death. This hypothesis has borne out in both preclinical models and in clinical trials testing PARP inhibitors in both BRCA-deficient and TNBC. The focus of this review will include an overview of the preclinical rationale for evaluating PARP inhibitors in TNBC, the presumed mechanism of action of this novel therapeutic class, promising results from several influential clinical trials of PARP inhibition in advanced breast cancer (both TNBC and BRCA-deficient), proposed mechanisms of acquired resistance to PARP inhibitors, and, finally, conclude with current challenges and future directions for the development of PARP inhibitors in the treatment of breast cancer.
title: Weird world of unexpected hosts: Pictorial review and Cases series of intra-abdominal round worms on ultrasound.
Creators: name: Babar, Khalid
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Anatomy
subject: Biliary Tract / Gallbladder
subject: Ultrasound
subject: Ultrasound-Colour Doppler
subject: Ultrasound-Power Doppler
subject: Diagnostic procedure
subject: Education
subject: Screening
subject: Biological effects
subject: Education and training
subject: Workforce

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: The aim of this pictorial essay is to demonstrate ultrasound features of round worm in abdomen and its associated complications. This contains; a) life cycle of ascaris. b) ultrasound features of worm in intestine, pancreato-biliary system and its...
(401276) Rachel Lyon Webster
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Radiosensitization of Epidermal Growth Factor Receptor/HER2-Positive Pancreatic Cancer Is Mediated by Inhibition of Akt Independent of Ras Mutational Status
Creators: name: Cox, Adrienne D.
name: Sartor, Carolyn I.
name: Vaseva, Angelina V.
name: Kimple, Randall J.
name: Tepper, Joel E.
name: Calvo, Benjamin F.
name: Shields, Janiel M.
name: Baerman, Kathryn M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Epidermal growth factor receptor family members (e.g., EGFR, HER2, HER3, and HER4) are commonly overexpressed in pancreatic cancer. We investigated the effects of inhibition of EGFR/HER2 signaling on pancreatic cancer to elucidate the role(s) of EGFR/HER2 in radiosensitization and to provide evidence in support of further clinical investigations.
title: A resident's guide: How not to get lost where we don't like to see: perianal fistulas
Creators: name: Avalos, Fernanda
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Anatomy
subject: Colon
subject: CT
subject: Fluoroscopy
subject: MR
subject: Education
subject: Abscess
subject: Fistula
subject: Inflammation

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: The objective of this article is to review the normal anatomy of the pelvis, what a fistula is, and how it is classified. Finally, propose a didactic guide to assess fistulas by...