cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Basis for monitoring the performance of Sustainable Development Goals in Organic Food Systems
A first approximation
Creators: name: Stefanovic, Lilliana
Publisher: name: Universität Kassel
Year: 2021
Subjects: subject: organic food system
subject: outcomes
subject: food systems transformation
subject: sustainable development goals
subject: 300
subject: Biologisches Lebensmittel
subject: Lebensmittelversorgung
subject: Nachhaltigkeit
subject: Ergebnis
subject: Transformation
subject: Vereinte Nationen: Agenda 2030 für nachhaltige Entwicklung

description: Zugleich: Universität Kassel, Dissertation, 2021
TLR4, NOD1 and NOD2 mediate immune recognition of putative newly identified periodontal pathogens
Creators: name: Kinney,
name: Giannobile,
name: Inohara,
name: Gerow,
name: Marchesan,
name: Jiao,
name: Schaff,
name: Paster,
name: Sheridan,
name: Morelli,
name: Rodrigues,
name: Hao,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Periodontitis is a polymicrobial inflammatory disease that results from the interaction between the oral microbiota and the host immunity. While the innate immune response is important for disease initiation and progression, the innate immune receptors that recognize both classical and putative periodontal pathogens that elicit an immune response have not been elucidated. By using the Human Oral Microbe Identification Microarray (HOMIM), we identified multiple predominant oral bacterial species in human plaque biofilm that strongly associate with severe periodontitis. Ten of the identified species were evaluated in greater depth, 6 being classical pathogens and 4 putative novel pathogens. Using human peripheral blood monocytes (HPBM) and murine bone marrow–derived macrophages (BMDM) from wild-type (WT) and toll-like receptor (TLR)-specific and MyD88 knockouts (KOs), we demonstrated that heat-killed Campylobacter concisus, Campylobacter rectus, Selenomonas infelix, Porphyromonas endodontalis, Porphyromonas gingivalis, and Tannerella forsythia mediate high immunostimulatory activity. C. concisus, C. rectus, and S. infelix exhibited robust TLR4 stimulatory activity. Studies using mesothelial cells from WT and NOD1-specific KOs and NOD2-expressing human embryonic kidney (HEK) cells demonstrated that Eubacterium saphenum, Eubacterium nodatum and Filifactor alocis exhibit robust NOD1 stimulatory activity, and that Porphyromonas endodontalis and Parvimonas micra have the highest NOD2-stimulatory activity. These studies allowed us to provide important evidence on newly-identified putative pathogens in periodontal disease pathogenesis showing that these bacteria exhibit different immunostimulatory activity via TLR4, NOD1, and NOD2 (Clinicaltrials.gov {"type":"clinical-trial","attrs":{"text":"NCT01154855","term_id":"NCT01154855"}}NCT01154855).
Dietary linoleic acid-induced alterations in pro- and anti-nociceptive lipid autacoids: Implications for idiopathic pain syndromes?
Creators: name: Taha, Ameer Y
name: Blanchard, Helene
name: Hammock, Bruce D
name: Zamora, Daisy
name: Ringel, Amit
name: Yang, Jun
name: Ramsden, Christopher E
name: Majchrzak-Hong, Sharon F
name: Davis, John M
name: Hibbeln, Joseph R
name: Loewke, James D
name: Rapoport, Stanley I
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Chronic idiopathic pain syndromes are major causes of personal suffering, disability, and societal expense. Dietary n-6 linoleic acid has increased markedly in modern industrialized populations over the past century. These high amounts of linoleic acid could hypothetically predispose to physical pain by increasing the production of pro-nociceptive linoleic acid-derived lipid autacoids and by interfering with the production of anti-nociceptive lipid autacoids derived from n-3 fatty acids. Here, we used a rat model to determine the effect of increasing dietary linoleic acid as a controlled variable for 15 weeks on nociceptive lipid autacoids and their precursor n-6 and n-3 fatty acids in tissues associated with idiopathic pain syndromes.
Measurement of exclusive $γγ\rightarrow \ell^+\ell^-$ production in proton-proton collisions at $\sqrt{s} = 7$ TeV with the ATLAS detector
Creators: name: ATLAS Collaboration
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: This Letter reports a measurement of the exclusive $γγ\rightarrow \ell^+\ell^- (\ell=e, μ)$ cross-section in proton-proton collisions at a centre-of-mass energy of 7 TeV by the ATLAS experiment at the LHC, based on an integrated luminosity of $4.6$ fb$^{-1}$. For the electron or muon pairs satisfying exclusive selection criteria, a fit to the dilepton acoplanarity distribution is used to extract the fiducial cross-sections. The cross-section in the electron channel is determined to be $σ_{γγ\rightarrow e^+e^-}^{\mathrm{excl.}} = 0.428 \pm 0.035 (\mathrm{stat.}) \pm 0.018 (\mathrm{syst.})$ pb for a phase-space region with invariant mass of the electron pairs greater than 24 GeV, in which both electrons have transverse momentum $p_\mathrm{T}>12$ GeV and pseudorapidity $|η|<2.4$. For muon pairs with invariant mass greater than 20 GeV, muon transverse momentum $p_\mathrm{T}>10$ GeV and pseudorapidity $|η|<2.4$, the cross-section is determined to be $σ_{γγ\rightarrow μ^+μ^- }^{\mathrm{excl.}} = 0.628 \pm 0.032 (\mathrm{stat.}) \pm 0.021 (\mathrm{syst.})$ pb. When proton absorptive effects due to the finite size of the proton are taken into account in the theory calculation, the measured cross-sections are found to be consistent with the theory prediction.
description: 12 pages + references + author list + cover pages (34 pages total), 4 figures, 3 tables, submitted to Phys. Lett. B, All figures including auxiliary figures are available at http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2014-13/
Conditional deletion of Pip5k1c in sensory ganglia and effects on nociception and inflammatory sensitization
Creators: name: Loo, Lipin
name: Zylka, Mark J
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Phosphatidylinositol 4-phosphate 5-kinase type 1 gamma (Pip5k1c) generates phosphatidylinositol 4,5-bisphosphate, also known as PI(4,5)P2 or PIP2. Many pronociceptive signaling pathways and receptor tyrosine kinases signal via PIP2 hydrolysis. Previously, we found that pain signaling and pain sensitization were reduced in Pip5k1c+/− global heterozygous knockout mice. Here, we sought to evaluate the extent to which dorsal root ganglia selective deletion of Pip5k1c affected nociception in mice. Initially, we crossed sensory neuron-selective Advillin-Cre mice with a conditional Pip5k1c knockout (cKO) allele (Pip5k1cfl/fl). However, these mice displayed an early onset proprioceptive deficit. To bypass this early onset phenotype, we used two different tamoxifen-inducible Cre lines (Brn3a-Cre-ERT2 and Advillin-Cre-ERT2) to conditionally delete Pip5k1c in adults. Tamoxifen induced high efficiency deletion of PIP5K1C in dorsal root ganglia and slightly reduced PIP5K1C in spinal cord and brain in Brn3a-Cre-ERT2 × Pip5k1cfl/fl (Brn3a cKO) mice while PIP5K1C was selectively deleted in dorsal root ganglia with no changes in spinal cord or brain in Advillin-Cre-ERT2 × Pip5k1cfl/fl (Advil cKO) mice. Acute thermosensation and mechanosensation were not altered in either line relative to wild-type mice. However, thermal hypersensitivity and mechanical allodynia recovered more rapidly in Brn3a cKO mice, but not Advil cKO mice, following hind paw inflammation. These data collectively suggest that PIP5K1C regulates nociceptive sensitization in more regions of the nervous system than dorsal root ganglia alone.
Ground-based multi-color observations of a young mid-M dwarf K2-25 to assess the effect of stellar activities on planetary transits
Creators: name: Mori, Mayuko
name: Ikuta, Kai
name: Fukui, Akihiko
name: Narita, Norio
Publisher: name: Zenodo
Year: 2023
Subjects: K2-25
Exoplanets
M-dwarfs
Starspots

description: Stellar magnetic activity affects exoplanet transit observations. In particular, unocculted spots and flares pose a problem in accurately measuring the depth of planetary transits in each wavelength, which result in misinterpretations of the planetary transmission spectra. Therefore, it is essential to evaluate stellar activities before attempting dedicated planetary characterization. Here, we focus on a young M4.5 dwarf K2-25. It is a well-studied system that shows brightness variations in the K2 light curves due to spots with a rotation period of 1.88 days. We conducted monitoring observations of K2-25 using the LCOGT worldwide ground-based telescopes in g- and z- bands for five months, including the TESS observation period. The derived monitoring light curves showed 1.88 days modulations in all bands. They showed clear differences in the modulation amplitudes, which are useful to constrain spot temperature and spot covering fractions. At the same time as the monitoring observations, we observed six transits of its planet K2-25b with the four-optical-band photometry instruments MuSCAT2 and 3. Although the transit depth variations due to the stellar activity were not detected, considering their uncertainties, the transit depth at each wavelength was useful to rule out the extreme stellar activity.
description: {"references": ["Rackham et al. (2018) ApJ 853 122", "Mann et al. (2016) ApJ 818 46", "Narita et al. (2018) JATIS 015001", "Narita et al. (2020) SPIE Proc. 114475K", "Kreidberg (2015) PASP 127 1161", "Foreman-Mackey et al. (2017) AJ 154 220", "Foreman-Mackey et al. (2013) PASP 125 306", "Morris et al. (2018), ApJ, 857, 39"]}
Social, environmental accounting and sustainability reporting (Lecture notes for Master and PhD students)
Creators: name: PASKO, Oleh
Publisher: name: Zenodo
Year: 2022
Subjects: Sustainability
Social accounting
Environmental accounting
Sustainability reporting
Sustainability-related assurance

description: Deliverable D1.2 - Didactic materials of the course Social and environmental accounting, sustainability reporting. Project “EU BEST PRACTICE OF LIFE CYCLE ASSESSMENT, SOCIAL, ENVIRONMENTAL ACCOUNTING AND SUSTAINABILITY REPORTING” 101047667 — EULASTING — ERASMUS-JMO-2021-HEI-TCH-RSCH https://bit.ly/3Bbvquw Pasko O. (2022) Social, environmental accounting and sustainability reporting [Electronic resource]: Lecture notes for Master and PhD students of the Faculty of Economics and Management, special. 071 Accounting and taxation and 073 – Management / Oleh Pasko; Sumy National Agrarian University. – Electronic text data. – Sumy: SNAU, 2022. – 167 p. – Access mode: https://zenodo.org/deposit/7262949 free (access date: dd.mm.yyyy). – Title from the screen. https://doi.org/10.5281/zenodo.7262949
The culture and consequences of Anglican church redundancy, 1945-1995: Leicestershire and Lincolnshire
Creators: name: Bonnette-Anderson, Denise
Publisher: name: University of Leicester
Year: 2023
Subjects: Uncategorized

description: This thesis explores what makes a church redundant and designated for closure in the modern era between 1945 and 1995 in the Church of England. Its central research focus is the culture embedded in the church redundancy process and the consequences of church closure for many communities. Following detailed exploration of the weighty ecclesiastical and parliamentary policy established to protect church buildings and create a formal church redundancy process, the inner workings, culture and the consequences of the Church of England’s attempts to cope with rapid social change in this period are analysed. The degree to which the secularisation debate became entrenched and how it shaped decision making are examined, and other socio-cultural issues are appraised for their effect on church redundancy. Refined case-study analyses of churches in the dioceses of Leicester and Lincoln draw on national data, and the heritage sector’s influence is explored. Finally, the social realities of the church communities in parishes where churches became redundant are considered afresh by examining objections to redundancy.This thesis uncovers more complex factors that affected churches’ viability than previously offered by historians and sociologists. The Church of England’s slow, bureaucratic working culture impeded some parish churches’ sustainability. While attempting to respond to rapid social change the Church and local planning authorities failed to foresee the consequences of policy decisions for local communities. Hence, each redundancy occurred for differing and sometimes overlapping reasons. Redundancy was not inevitable future for churches with low attendance and usually resulted from a series of circumstances over time. Few cases were connected directly with secularisation, often reflecting a combination of a changing population, financial challenges, maintenance issues and a shortage of clergy. These problems were exacerbated by tensions and conflict between heritage bodies seeking to protect historic buildings, the Church trying to maintain its spiritual mission and the parish community endeavouring to worship in its church.
Asplenium drepanophyllum Kunze, Linnaea
Creators: name: Kessler, Michael
name: Smith, Alan R.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Polypodiales
Aspleniaceae
Asplenium
Asplenium drepanophyllum

description: Asplenium drepanophyllum Kunze, Linnaea 9: 66. 1834.
 Range:— Peru to northwestern Argentina, Paraguay, and southeastern Brazil. In Bolivia, in BE, CH, CO, LP, and SC.
 Ecology:— Fairly common; terrestrial, rarely on rocks, mostly in semihumid forests; 450–1700 m.
 Notes:— Differs from A. bangii by more strongly biserrate pinnae, fewer pinnae per blade, and forked basiscopic veins; from A. discrepans differing by having more deeply toothed, biserrate pinna margins and more apically acute pinnae.
description: Published as part of Kessler, Michael & Smith, Alan R., 2018, Prodromus of a fern flora for Bolivia. XXIX. Aspleniaceae, pp. 259-280 in Phytotaxa 344 (3) on pages 259-280, DOI: 10.11646/phytotaxa.344.3.6, http://zenodo.org/record/13720625
Reduction Sensitive PEG Hydrogels for Codelivery of Antigen and Adjuvant To Induce Potent CTLs
Creators: name: Tian, Shaomin
name: Perry, Jillian L.
name: Kapadia, Chintan H.
name: Desimone, Joseph M.
name: Luft, J. Christopher
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Educating our immune system via vaccination is an attractive approach to combat infectious diseases. Eliciting antigen specific cytotoxic T cells (CTLs), CD8 + effector T cells, is essential in controlling intracellular infectious diseases such as influenza (Flu), tuberculosis (TB), hepatitis, and HIV/AIDS, as well as tumors. However, vaccination utilizing subunit peptides to elicit a potent CD8 + T cell response with antigenic peptides is typically ineffective due to poor immunogenicity. Here we have engineered a reduction sensitive nanoparticle (NP) based subunit vaccine for intracellular delivery of an antigenic peptide and immunostimulatory adjuvant. We have co-conjugated an antigenic peptide (ovalbumin-derived CTL epitope [OVA 257-264 : SIINFEKL]) and an immunostimulatory adjuvant (CpG ODNs, TLR9 agonist) to PEG hydrogel NPs via a reduction sensitive linker. Bone-marrow derived dendritic cells (BMDCs) treated with the SIINFEKL conjugated NPs efficiently cross-presented the antigenic peptide via MHC-I surface receptor and induced proliferation of OT-I T cells. CpG ODN-conjugated NPs induced maturation of BMDCs as evidenced by the overexpression of CD80 and CD40 costimulatory receptors. Moreover, codelivery of NP conjugated SIINFEKL and CpG ODN significantly increased the frequency of IFN-γ producing CD8 + effector T cells in mice (∼6-fold improvement over soluble antigen and adjuvant). Furthermore, the NP subunit vaccine-induced effector T cells were able to kill up to 90% of the adoptively transferred antigenic peptide-loaded target cell. These results demonstrate that the reduction sensitive NP subunit vaccine elicits a potent CTL response and provide compelling evidence that this approach could be utilized to engineer particulate vaccines to deliver tumor or pathogen associated antigenic peptides to harness the immune system to fight against cancer and infectious diseases.
Physics Teachers' Technological Pedagogical Content Knowledge and Problems in the Instructional Management under the Secondary Educational Service Area Office Sukhothai in the Situation of Coronavirus Pandemic
Creators: name: Arrak Praprom
Publisher: name: Science Education Association (Thailand)
Year: 2022
Subjects: Technological Pedagogical Content Knowledge
Problems in Physics Instructional Management
COVID-19 Pandemic

description: International Journal of Science Education and Teaching, 1, 2, 87-95
title: Usual and Unusual Suspect in Protecting EU Values: An Introduction
Creators: name: Bonelli, Matteo
name: Claes, Monica
name: De Witte, Bruno
name: Podstawa, Karolina
Publisher: name: European Papers (www.europeanpapers.eu)
Year: 2022
Subjects: subject: EU values
subject: rule of law
subject: Court of Justice
subject: conditionality
subject: peer review
subject: constitutional crises

description: European Papers - A Journal on Law and Integration, 2022 7(2), 641-650
description: I. Protecting EU values: The state of affairs. - II. Protecting EU values: The debate. - III. The Special Section. - IV. The contributions.
description: This Article introduces the Special Section "Usual and Unusual Suspects: New Actors, Roles and Mechanisms to Protect EU Values" which collects four Articles originally presented at the NOVA workshop "EU Democracy and the Rule of Law" in June 2021. The four Articles all reflect of how the EU institutions may protect and promote the common values in the Member States, in particular in the context of the ongoing constitutional crises in Hungary and Poland, but looking also at the medium and long-term efforts the EU is called to put in place to prevent new crises and promote a stronger rule of law culture in the Member States and civil society. This Article serves to place the considerations offered in those four contributions against two backgrounds: the current and evolving state of affairs, in which democratic and rule of law questions seem to emerge more and more strongly; and the institutional and academic debate that has taken place in the last decade. We argue that the Articles of this Special Section bring an original and innovative perspective to the debate, showing that the EU response must be based on a combination of political, judicial and financial tools, and that the EU needs to both try to respond to ongoing crisis and construct a stronger toolkit for the future.
Life cycle assessment: EU best practices (Didactic materials of the course)
Creators: name: Koblianska, Inna
Publisher: name: Zenodo
Year: 2022
Subjects: Life cycle assessment

description: Deliverable D1.1 - Didactic materials of the course "Life cycle assessment: EU best practices"  Project: “EU BEST PRACTICE OF LIFE CYCLE ASSESSMENT, SOCIAL, ENVIRONMENTAL ACCOUNTING AND SUSTAINABILITY REPORTING” 101047667 — EULASTING — ERASMUS-JMO-2021-HEI-TCH-RSCH https://bit.ly/3Bbvquw Koblianska I. (2022) Life cycle assessment: EU best practices [Electronic resource]: Lecture notes for Master and Ph.D. students of the Faculty of Economics and Management, special. 051 Economics and 073 – Management / Inna Koblianska; Sumy National Agrarian University. – Electronic text data. – Sumy: SNAU, 2022. – 112 p. – Access mode: https://zenodo.org/deposit/7262964 (access date: dd.mm.yyyy). – Title from the screen. https://doi.org/10.5281/zenodo.7262964
Science Pre-service Teacher Reflection on Pedagogical Knowledge and Other Essential Practical Skills Needed for Practicum according to School Context in ThailandExamining Senior High School Students' Ability in Constructing Scientific Explanation of Galvanic Cell
Creators: name: Chontawat Meedee
Publisher: name: Science Education Association (Thailand)
Year: 2022
Subjects: Scientific Explanation
Electrochemistry
Critical Action Research

description: International Journal of Science Education and Teaching, 1, 2, 96-116
Tumor-Associated Macrophage-Mediated Targeted Therapy of Triple-Negative Breast Cancer
Creators: name: Naguib, Youssef W.
name: Cui, Zhengrong
name: Niu, Mengmeng
name: Hursting, Stephen D.
name: Valdes, Solange
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Triple-negative breast cancer (TNBC) is the most aggressive form of breast cancer. TNBC is often infiltrated with a large number of macrophages, which in turn promote tumor growth and metastasis. In this study, tumor-associated macrophages (TAMs) were exploited as a target to deliver doxorubicin (DOX), a chemotherapeutic agent, to TNBC using nanoparticles surface-functionalized by i) acid-sensitive sheddable PEGylation and ii) modifying with mannose (i.e. DOX-AS-M-PLGA-NPs). In mice with orthotopic M-Wnt triple-negative mammary tumors, a single intravenous injection of DOX-AS-M-PLGA-NPs significantly reduced macrophage population in tumors within 2 days, and the density of the macrophages recovered slowly. Repeated injections of DOX-AS-M-PLGA-NPs can help maintain the population of the macrophages at a lower level. In M-Wnt tumor-bearing mice that were pre-treated with zoledronic acid to non-selectively deplete macrophages, the TAM-targeting DOX-AS-M-PLGA-NPs were not more effective than the DOX-AS-PLGA-NPs that were not surface-modified with mannose, and thus do not target TAMs, in controlling tumor growth. However, in M-Wnt tumor-bearing mice that were not pre-treated with zoledronic acid, the TAM-targeting DOX-AS-M-PLGA-NPs were significantly more effective than the non-targeting DOX-AS-PLGA-NPs in controlling the tumor growth. The AS-M-PLGA-NPs or other nanoparticles surface-functionalized similarly, when loaded with chemotherapeutic agents commonly used in adjuvant therapy of TNBC, may be developed into targeted therapy of TNBC.
Fluctuation-dissipation relation between shear stress relaxation modulus and shear stress autocorrelation function revisited
Creators: name: Wittmer, J. P.
name: Xu, H.
name: Benzerara, O.
name: Baschnagel, J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: The shear stress relaxation modulus $G(t)$ may be determined from the shear stress $τ(t)$ after switching on a tiny step strain $γ$ or by inverse Fourier transformation of the storage modulus $G^{\prime}(ω)$ or the loss modulus $G^{\prime\prime}(ω)$ obtained in a standard oscillatory shear experiment at angular frequency $ω$. It is widely assumed that $G(t)$ is equivalent in general to the equilibrium stress autocorrelation function $C(t) = βV \langle δτ(t) δτ(0)\rangle$ which may be readily computed in computer simulations ($β$ being the inverse temperature and $V$ the volume). Focusing on isotropic solids formed by permanent spring networks we show theoretically by means of the fluctuation-dissipation theorem and computationally by molecular dynamics simulation that in general $G(t) = G_{eq} + C(t)$ for $t > 0$ with $G_{eq}$ being the static equilibrium shear modulus. A similar relation holds for $G^{\prime}(ω)$. $G(t)$ and $C(t)$ must thus become different for a solid body and it is impossible to obtain $G_{eq}$ directly from $C(t)$.
description: 13 pages, 15 figures
title: Der Mini-Audio-Test (MAT) – eine Screeningmethode auf Schwerhörigkeit für Haus- und grundversorgende Fachärzte
Creators: name: Lehmann, Martin
name: Volkenstein, Stefan
name: Dazert, Stefan
name: Löhler, Jan
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Etwa 15 Millionen Menschen leiden in Deutschland an einer Schwerhörigkeit, doch nur 16% nutzen Hörgeräte. Diese Unterversorgung kann für die Betroffenen zu gravierenden Folgen, wie sozialer Isolation, Depression und Förderung einer Demenz, führen. Ein frühzeitiges[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
Information Dissemination through Motion Picture : An Overview
Creators: name: Adak, Mousumi
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 461099
subject: Library and information studies not elsewhere classified

description: The ability to disseminate information is a major characteristic of center any information centre. Any media form can be used to maintain this character. This paper will be making an attempt to discover if this is truly achievable.RESEARCH METHODOLOGY: Steps1) Critical analysis of a few Motion Picture of Indian origin2) A detailed study of the material of said motion pictures to find potential information that they were trying to conveyDATA COLLECTION: The data were collected from a few selected motion pictures from the year 1957 to 2016.FINDINGS: With the analysis of the selected Motion Pictures we can determine that depending on the nature or class of motion picture, it can disseminate information. As it is a social medium, generally it’s in the realm of social conditions, trying to educate or grow awareness on a subject while circulating information.
Asplenium davisii Stolze, Fieldiana, Bot.
Creators: name: Kessler, Michael
name: Smith, Alan R.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Polypodiales
Aspleniaceae
Asplenium
Asplenium davisii

description: Asplenium davisii Stolze, Fieldiana, Bot., n.s. 32: 30. 1993.
 Range:— Peru and Bolivia (BE, CO, LP, SC).
 Ecology:— Uncommon; terrestrial in humid forests; 400–1700 m, to sea level elsewhere.
 Notes:— Differs from the commoner A. tricholepis by crenate pinna margins, minute, appressed, dark brown hairs abaxially on the blade surfaces (vs. glabrous), and terrestrial habit (vs. epiphytic).
description: Published as part of Kessler, Michael & Smith, Alan R., 2018, Prodromus of a fern flora for Bolivia. XXIX. Aspleniaceae, pp. 259-280 in Phytotaxa 344 (3) on pages 259-280, DOI: 10.11646/phytotaxa.344.3.6, http://zenodo.org/record/13720625
Asplenium dimidiatum Sw., Prodr.
Creators: name: Kessler, Michael
name: Smith, Alan R.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Polypodiales
Aspleniaceae
Asplenium
Asplenium dimidiatum

description: Asplenium dimidiatum Sw., Prodr. 129. 1788.
 Range:— Greater Antilles; Costa Rica; patchily from Colombia to Bolivia (LP).
 Ecology:— Fairly common; terrestrial and epiphytic, rarely saxicolous, in semihumid forests; 900–1300(2350 m), down to 650 m elsewhere.
 Notes:— Closely related to A. praemorsum, but differing in having less dissected blades and broader rhizome scales.
description: Published as part of Kessler, Michael & Smith, Alan R., 2018, Prodromus of a fern flora for Bolivia. XXIX. Aspleniaceae, pp. 259-280 in Phytotaxa 344 (3) on pages 259-280, DOI: 10.11646/phytotaxa.344.3.6, http://zenodo.org/record/13720625
Discovery and Characterization of Novel GPR39 Agonists Allosterically Modulated by Zinc
Creators: name: Kroeze, Wesley K.
name: Roth, Bryan L.
name: Huang, Xi-Ping
name: Sato, Seiji
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: In this study, we identified two previously described kinase inhibitors—3-(4-chloro-2-fluorobenzyl)-2-methyl-N-(3-methyl-1H-pyrazol-5-yl)-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine (LY2784544) and 1H-benzimidazole-4-carboxylic acid, 2-methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-6-(4-morpholinyl)- (GSK2636771)—as novel GPR39 agonists by unbiased small-molecule-based screening using a β-arrestin recruitment screening approach (PRESTO-Tango). We characterized the signaling of LY2784544 and GSK2636771 and compared their signaling patterns with a previously described “GPR39-selective” agonist N-[3-chloro-4-[[[2-(methylamino)-6-(2-pyridinyl)-4- pyrimidinyl]amino]methyl]phenyl]methanesulfonamide (GPR39-C3) at both canonical and noncanonical signaling pathways. Unexpectedly, all three compounds displayed probe-dependent and pathway-dependent allosteric modulation by concentrations of zinc reported to be physiologic. LY2784544 and GS2636771 at GPR39 in the presence of zinc were generally as potent or more potent than their reported activities against kinases in whole-cell assays. These findings reveal an unexpected role of zinc as an allosteric potentiator of small-molecule-induced activation of GPR39 and expand the list of potential kinase off-targets to include understudied G protein–coupled receptors.
title: Prävalenz von Risikofaktoren für Hörstörungen in einer Lost-to-Follow-Up Neugeborenenkohorte aus dem Neugeborenen-Hörscreening Programm
Creators: name: Thangavelu, Kruthika
name: Fabian, Silke
name: Lang, Stephan
name: Lang-Roth, Ruth
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Seit 2009 ist das universelle Neugeborenen-Hörscreening, zur Früherkennung einer Schwerhörigkeit sowie zu ihrer Frühversorgung, Teil des nationalen Screening-Programms für Neugeborene in Deutschland. Bei zur Follow-Up-Untersuchung nicht erscheinen Neugeborenen (Lost-to-Follow-up[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
title: Judicial Responses to Autocratic Legalism: The European Court of Justice in a Cleft Stick?
Creators: name: Bornemann, Jonas
Publisher: name: European Papers (www.europeanpapers.eu)
Year: 2022
Subjects: subject: autocratic legalism
subject: European Court of Justice
subject: rule of law
subject: refugee crisis
subject: Poland
subject: Hungary

description: European Papers - A Journal on Law and Integration, 2022 7(2), 651-670
description: I. Introduction. - II. Autocratic legalism: a threat to the ECJ's authority. - II.1. Autocratic counter-interpretations of Union law. - II.2. An autocratic contestation of the ECJ's authority. - III. A constitutional response to a crisis of values. - III.1. A dynamic response to the formalism of autocratic legal-ism. - III.2. A flexible response to a crisis of values. - IV. Alternative responses to autocratic legalism. - IV.1. Decentralised solutions to a crisis of values. - IV.2. Administrative reasoning as a response to autocratic legalism. - V. Conclusion.
description: In recent years, the Court of Justice has become one of the most pronounced voices of opposition to illiberal projects in Europe. Its tenacity, however, has turned the Court into the target of national lawmakers who seek to undermine the authority of the Court and Union law more generally. The present investigation suggests that these attacks share recurrent features and may be qualified as "autocratic legalism". It will be argued that, above all, attacks of this nature are aimed at calling into question the authority of the European Court of Justice among national audiences. For European judges, consequently, this raises the question how to appropriately respond to such efforts. Although there may be no ideal solution in this regard, the present investigation discerns three responses in the jurisprudence of the Court and assesses these approaches in the light of the strategic objectives pursued by autocratic legalists.
Asplenium depauperatum Fee, Mem. Foug.
Creators: name: Kessler, Michael
name: Smith, Alan R.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Polypodiales
Aspleniaceae
Asplenium
Asplenium depauperatum

description: Asplenium depauperatum Fée, Mém. Foug. 7: 52, t. 15, f. 3. 1857.
 Range:— Andes of Bolivia (CH, CO, LP, SC, TA) and northwestern Argentina; southeastern Brazil, adjacent Paraguay and northeastern Argentina.
 Ecology:— Fairly common; terrestrial on open ground on steep slopes, especially in ravines, in deciduous and semideciduous forests; 500–2700 m.
 Notes:— Distinctive; all other Bolivian species with proliferous blade apices differ by their larger size, more erect growth, and much less deeply divided ultimate segments.
description: Published as part of Kessler, Michael & Smith, Alan R., 2018, Prodromus of a fern flora for Bolivia. XXIX. Aspleniaceae, pp. 259-280 in Phytotaxa 344 (3) on pages 259-280, DOI: 10.11646/phytotaxa.344.3.6, http://zenodo.org/record/13720625
title: Untersuchungen zur Endotypdefinition der chronischen Rhinosinusitis mit und ohne Polyposis basierend auf der Expression von Zelladhäsionsproteinen
Creators: name: Abbaspour, Bektasch
name: Beule, Achim Georg
name: Nierkamp, Inga
name: Stübke, Katrin
name: Rudack, Claudia
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die Epithelbarriere unterliegt bei der chronischen Rhinosinusitis immunopathologischer Umbauprozesse, welche Gegenstand unserer Untersuchungen sind. Zelladhaesivmoleküle, wie das Desmoglein 2, spielen bei dem Zell-Zell Kontakt eine tragende Rolle und garantieren die Stabilität [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
A New Molecular Mechanism To Engineer Protean Agonism at a G Protein–Coupled Receptor
Creators: name: Kloeckner, Jessica
name: Mohr, Klaus
name: Holzgrabe, Ulrike
name: Traenkle, Christian
name: Matera, Carlo
name: Muth, Mathias
name: Kostenis, Evi
name: Kenakin, Terry
name: Holze, Janine
name: De Min, Anna
name: Dallanoce, Clelia
name: Schrage, Ramona
name: Bock, Andreas
name: De Amici, Marco
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Protean agonists are of great pharmacological interest as their behavior may change in magnitude and direction depending on the constitutive activity of a receptor. Yet, this intriguing phenomenon has been poorly described and understood, due to the lack of stable experimental systems and design strategies. In this study, we overcome both limitations: First, we demonstrate that modulation of the ionic strength in a defined experimental set-up allows for analysis of G protein-coupled receptor activation in the absence and presence of a specific amount of spontaneous receptor activity using the muscarinic M2 acetylcholine receptor as a model. Second, we employ this assay system to show that a dualsteric design principle, that is, molecular probes, carrying two pharmacophores to simultaneously adopt orthosteric and allosteric topography within a G protein-coupled receptor, may represent a novel approach to achieve protean agonism. We pinpoint three molecular requirements within dualsteric compounds that elicit protean agonism at the muscarinic M2 acetylcholine receptor. Using radioligand-binding and functional assays, we posit that dynamic ligand binding may be the mechanism underlying protean agonism of dualsteric ligands. Our findings provide both new mechanistic insights into the still enigmatic phenomenon of protean agonism and a rationale for the design of such compounds for a G protein-coupled receptor.
title: Der Einsatz des 3D-Druckers in der otochirurgischen Ausbildung und präperativen Vorbereitung
Creators: name: Kansy, Benjamin
name: Christov, Florian
name: Arnolds, Judith
name: Hansen, Stefan
name: Lang, Stefan
name: Ringelstein, Adrian
name: Arweiler Harbeck, Diana
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die Einführung in die komplexere Otochirurgie findet in der Regel am humanen Präparat in Felsenbeinkursen statt. Die Anzahl der Präparate ist jedoch aufgrund der Spenderzahl und des Kostenfaktors begrenzt. Zusätzlich besteht bei komplexen Anatomischen Verhältnissen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
Compressibility and pressure correlations in isotropic solids and fluids
Creators: name: Wittmer, J. P.
name: Xu, H.
name: Polinsak, P.
name: Gillig, C.
name: Helfferich, J.
name: Weysser, F.
name: Baschnagel, J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Presenting simple coarse-grained models of isotropic solids and fluids in $d=1$, $2$ and $3$ dimensions we investigate the correlations of the instantaneous pressure and its ideal and excess contributions at either imposed pressure (NPT-ensemble, $λ=0$) or volume (NVT-ensemble, $λ=1$) and for more general values of the dimensionless parameter $λ$ characterizing the constant-volume constraint.
description: 17 pages, 9 figures
title: The Ubiquitin Ligase RNF138 Cooperates with CtIP to Stimulate Resection of Complex DNA Double-Strand Breaks in Human G1-Phase Cells
Creators: name: Averbeck, Nicole B.
name: Barent, Carina
name: Jakob, Burkhard
name: Syzonenko, Tatyana
name: Durante, Marco
name: Taucher-Scholz, Gisela
Publisher: name: MDPI
Year: 2022

description: DNA double-strand breaks (DSBs) represent the molecular origin of ionizing-radiation inflicted biological effects. An increase in the ionization density causes more complex, clustered DSBs that can be processed by resection also in G1 phase, where repair of resected DSBs is considered erroneous and may contribute to the increased biological effectiveness of heavy ions in radiotherapy. To investigate the resection regulation of complex DSBs, we exposed G1 cells depleted for different candidate factors to heavy ions or α-particle radiation. Immunofluorescence microscopy was used to monitor the resection marker RPA, the DSB marker γH2AX and the cell-cycle markers CENP-F and geminin. The Fucci system allowed to select G1 cells, cell survival was measured by clonogenic assay. We show that in G1 phase the ubiquitin ligase RNF138 functions in resection regulation. RNF138 ubiquitinates the resection factor CtIP in a radiation-dependent manner to allow its DSB recruitment in G1 cells. At complex DSBs, RNF138′s participation becomes more relevant, consistent with the observation that also resection is more frequent at these DSBs. Furthermore, deficiency of RNF138 affects both DSB repair and cell survival upon induction of complex DSBs. We conclude that RNF138 is a regulator of resection that is influenced by DSB complexity and can affect the quality of DSB repair in G1 cells.
title: Progression of Niemann-Pick disease type C in a paediatric patient
Creators: name: Meglic, Jakob
Publisher: name: EURORAD
Year: 2023
Subjects: subject: Neuroradiology
subject: Neuroradiology brain
subject: MR
subject: Metabolic disorders
subject: Clinical Cases

description: Clinical History: A 17-year-old boy experienced daily seizures and cataplectic episodes. Audiometry revealed hearing loss on the left. Somatosensory evoked potential test showed prolonged cortical responses and central conduction, with weaker right-side cortical response. Minor liver enlargement, dysphagia, rapidly progressing learning disability, memory issues, and increased clumsiness with walking difficulties were present. The first neurological symptoms appeared at 6 years of age.

description: 17 years, male
A Scale of Agonism and Allosteric Modulation for Assessment of Selectivity, Bias, and Receptor Mutation
Creators: name: Kenakin, Terry
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: An index of agonism is described that can be used to quantify agonist receptor selectivity, bias, cell-based agonism, and the effects of receptor mutation on signaling. The parameter is derived from agonist concentration-response curves and comprises the maximal response to the agonist (max) and the EC50 in the form of Δlog(max/EC50). This parameter is derived from equations describing agonists as positive allosteric facilitators of receptor-signaling protein interaction. A similar index is also derived to quantify the potentiating effects of positive allosteric modulators, which can be used to quantify in situ positive allosteric modulator activity in vivo. These indices lend themselves to statistical analysis and are system-independent in that the effects of the system processing of agonist response and differences in assay sensitivity and receptor expression are cancelled. The various applications of the Δlog(max/EC50) scale are described for each pharmacologic application.
title: Marsupialisation einer Tornwaldt’schen Zyste mittels CO2-Laser über eine flexible Faser
Creators: name: Tache, Petrut
name: Henschke, Frank
name: Folz, Benedikt J.
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: Tornwaldtzyste
subject: Marsupialisation
subject: CO2-Laser
subject: 610 Medical sciences; Medicine

description: Einleitung: Die Tornwaldt'sche Zyste (TZ), eine submuköse Raumforderung in Fossa Rosenmüller, ist eine chronische Entzündung der Bursa pharyngealis. Ohne klinisches Korrelat kommt die TZ bei 4 % der Bevölkerung vor. Extensive radiologische Studien beschreiben eine Inzidenz[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
Efficient, designable, and broad-bandwidth optical extinction via aspect-ratio-tailored silver nanodisks
Creators: name: Anquillare, Emma L.
name: Miller, Owen D.
name: Hsu, Chia Wei
name: DeLacy, Brendan G.
name: Joannopoulos, John D.
name: Johnson, S. G.
name: Soljacic, Marin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Subwavelength resonators, ranging from single atoms to metallic nanoparticles, typically exhibit a narrow-bandwidth response to optical excitations. We computationally design and experimentally synthesize tailored distributions of silver nanodisks to extinguish light over broad and varied frequency windows. We show that metallic nanodisks are two-to-ten-times more efficient in absorbing and scattering light than common structures, and can approach fundamental limits to broadband scattering for subwavelength particles. We measure broadband extinction per volume that closely approaches theoretical predictions over three representative visible-range wavelength windows, confirming the high efficiency of nanodisks and demonstrating the collective power of computational design and experimental precision for developing new photonics technologies.
title: Endoscopic Treatment of Medial Orbital Wall Fractures
Creators: name: Mici, Elidon
name: Belli, Evaristo
name: Duong Dinh, Thien An
name: Westhofen, Martin
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: Isolated medial wall fractures are easily missed under clinical assessment, and those cases necessitating surgery are relatively rare. In the last decades, diagnostic imaging, surgical techniques, availability of alloplastic materials, as well as evolution of surgical instruments have [for full text, please go to the a.m. URL]
description: Jahrestagung der Vereinigung Westdeutscher Hals-Nasen-Ohren-Ärzte
A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder
Creators: name: Olsson,
name: Smoller,
name: Lichtenstein,
name: Sullivan,
name: Sellgren,
name: Walther-Jallow,
name: Ekman,
name: Larsson,
name: Vawter,
name: Erhardt,
name: Schalling,
name: Backlund,
name: Svensson,
name: Engberg,
name: Hultman,
name: Bergen,
name: Kegel,
name: Landén,
name: Magnusson,
name: Sklar,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Elevated cerebrospinal fluid (CSF) levels of the glia-derived N-methyl-D-aspartic acid receptor antagonist kynurenic acid (KYNA) have consistently been implicated in schizophrenia and bipolar disorder. Here, we conducted a genome-wide association study based on CSF KYNA in bipolar disorder and found support for an association with a common variant within 1p21.3. After replication in an independent cohort, we linked this genetic variant—associated with reduced SNX7 expression—to positive psychotic symptoms and executive function deficits in bipolar disorder. A series of post-mortem brain tissue and in vitro experiments suggested SNX7 downregulation to result in a caspase-8-driven activation of interleukin-1β and a subsequent induction of the brain kynurenine pathway. The current study demonstrates the potential of using biomarkers in genetic studies of psychiatric disorders, and may help to identify novel drug targets in bipolar disorder.
Emission lines variability of young accreting planets and brown-dwarf companions
Creators: name: Demars, Dorian
name: Bonnefoy, Mickael
name: Dougados, Catherine
name: Thanathibodee, Thanawuth
name: Delorme, Philippe
name: Aoyama, Yuhiko
name: Tessore, Benjamin
name: Palma-Bifani, Paulina
name: Petrus, Simon
name: Sousa, Alana
name: Marleau, Gabriel-Dominique
name: Bouvier, Jérôme
name: Chauvin, Gaël
name: Lagrange, Anne-Marie
Publisher: name: Zenodo
Year: 2023

description: We present the results of a monitoring campaign of the Paschen β emission lines (1.28µm) of two accreting 10-30M Jup companions with the VLT/SINFONI integral field spectrograph : GQ Lup b and GSC 06214-00210 b. We evidence variability of line intensities and profiles on minutes to years timescales on both objects. These behaviors are reminiscent of rotation-modulated variability observed on CTTS and a signpost of magnetospheric accretion. The line properties are compared to predictions from a scaled-down version of the stellar magnetospheric accretion (MA) models and to the latest disk-driven accretion models of protoplanets nested within circumstellar disks. The line properties of GQ Lup b are reproduced by MA models while those of GSC 06214-00210 b are better fitted by disk-driven accretion models (protoplanets). New MA models with inclined dipoles and monitoring observations at higher spectral resolving powers over one rotation period (1h to several days) could help confirming the mechanisms at play on these two objects. We discuss the implication of our findings for the protoplanet detection based on their line emission (e.g., VLT/MUSE, Magelan/MagAO-X).
description: {"references": ["Aoyama, Y., Ikoma, M., & Tanigawa, T. 2018, ApJ, 866, 84", "Thanathibodee, T., Calvet, N., Bae, J., Muzerolle, J., & Hern\u00e1ndez, R. F. 2019, ApJ, 885, 94"]}
title: Fischverzehr in Schwangerschaft und Stillzeit: Einige Fischarten weisen hohe Methylquecksilber-Gehalte auf: Stellungnahme Nr. 047/2023 des BfR vom 11. Oktober 2023
Creators: name: Bundesinstitut Für Risikobewertung
Publisher: name: Bundesbehörden und Einrichtungen im Geschäftsbereich des Bundesministeriums für Ernährung und Landwirtschaft (BMEL)
Year: 2023
Subjects: subject: 000

description: BfR-Stellungnahmen, vol. 2023, no. 047