cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
ESHITISHDA NUQSONI BO'LGAN BOLALARNI IJTIMOIY HAYOTGA YO'NALTIRISH
Creators: name: Ahmedova, Maftuna
Publisher: name: Zenodo
Year: 2025

description: Ushbu maqolada eshitishda nuqsoni bo’lgan bolalarni ijtimoiy hayotdagi o’rni va ularni jamiyatga moslashtirish jarayonlarini o’rgatadi.Xulosalar shuni ko’rsatadiki bu toifadagi bolalarning kommunikativ ko’nikmalarini rivojlantirib,ularni ijtimoiy muhitga integratsiyasini ta’minlash va o’zini anglash hissini shakillantirishga qaratilgan yondashuvlar  ko’rib chiqiladi. SHuningdek, oilaviy, pedogagik va psixolagik qo’llab-quvvatlahsning ro’li kata. Asosiy maqsad-eshitishda nuqsoni bo’lgan bolalarning to’laqonli hayot kechirishlari uchun zarur sharoitlarni yaratish va ularni jamiyatga faol jalb etish yo’llarini ko’rsatishdir.
title: Newsletter Institut für Allgemeinmedizin und Palliativmedizin Ausgabe Januar 2022
Creators: name: Medizinische Hochschule Hannover
Publisher: name: Medizinische Hochschule Hannover Bibliothek
Year: 2022
Subjects: subject: 610

description: Newsletter Allgemeinmedizin und Palliativmedizin, vol. 2022, no. 1
La mise en forme juridique de l’expertise psychiatrique sur la traitabilité des « délinquants dangereux » : l’état du droit criminel canadien
Creators: name: Euchi, Haythem
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: droit criminel
expertise psychiatrique
traitabilité
délinquants dangereux
théorie des systèmes
nouvelle pénologie

description: La présente recherche est de type exploratoire et porte sur la mise en forme juridique de l’expertise psychiatrique quant à la traitabilité des « délinquants dangereux ». Les observations sont menées en contexte canadien et couvrent quatre provinces, soit l’Alberta, le Québec, l’Ontario et la Nouvelle-Écosse de 2008 à 2012. La recherche est basée sur deux apports théoriques : l’avènement de la « nouvelle pénologie » et la théorie des systèmes autopoïétiques de Niklas Luhmann. La « traitabilité » est ainsi conçue comme un médium de communication auquel se réfèrent les systèmes psychiatrique et juridique pour construire, respectivement, leur propre conception de la traitabilité. Nos analyses démontrent que, du point de vue psychiatrique, la « traitabilité » renvoie, comme mise en forme principale, à la capacité de changement chez le délinquant. Pour les experts, le médium est ainsi investi pour promouvoir un idéal réhabilitatif et transformatif de l’individu : la forte majorité des délinquants sont, à différents niveaux, considérés traitables. Apparaît dans ce cadre une distinction entre le désir déviant et sa transposition en comportements déviants. Si le désir déviant ne peut pas être changé, le comportement, lui, peut être altéré ou refoulé par l’entremise de l’intervention thérapeutique. Pour les experts, la présence du désir ne représente pas un problème en soi si celui-ci ne débouche pas sur des actes concrets. Dans le contexte de la détermination de la peine, ces communications psychiatriques sont récupérées et réinvesties par le système juridique. Les principes réhabilitatifs promus par les experts cèdent la place à de nouveaux sens et à de nouvelles significations proprement juridiques. Ces dernières puisent leur essence principalement dans la neutralisation et la protection de la société, moins dans la capacité de changement du délinquant. Si la « traitabilité » dans son sens réhabilitatif est fortement représentée dans le discours des experts, le même médium ainsi que ces mises en forme psychiatriques sont investis tout autrement dans le système juridique. Pour ce système, dans l’ordre des priorités, le changement individuel apparaît secondaire par rapport à la protection de la société, vue comme prioritaire. La neutralisation de l’individu, notamment par son incarcération, se présente alors comme la meilleure protection. Le risque de récidive est non seulement neutralisé, mais la responsabilité du traitement en détention est en même temps transférée sur le délinquant. Le système, ainsi, s’autodécrit comme protégeant la société contre le crime. D’un point de vue sociologique, on remarque en même temps que ce faisant, le système se ‘’protège’’ lui-même contre la critique qui voudrait lui imputer la responsabilité de la non réhabilitation.
Quantification of Neurological Blood-Based Biomarkers in Critically Ill Patients With Coronavirus Disease 2019
Creators: name: Cooper, Jennifer
name: Stukas, Sophie
name: Hoiland, Ryan
name: Fergusson, Nicholas
name: Thiara, Sonny
name: Foster, Denise
name: Mitra, Anish
name: Stoessl, A. Jon
name: Panenka, William J.
name: Sekhon, Mypinder S.
name: Wellington, Cheryl L.
Publisher: name: Wolters Kluwer
Year: 2021

description: Objectives: To provide an objective characterization of acute neurologic injury in critically ill patients with coronavirus disease 2019. Design: Prospective observational study. Demographics, comorbidities, and daily clinical physiologic and laboratory data were collected. Plasma levels of neurofilament-light chain, total tau, ubiquitin carboxyterminal hydrolase L1, and glial fibrillary acidic protein were measured. The primary neurologic outcome was delirium defined by the Intensive Care Delirium Screening Checklist (scale 1–8). Associations among plasma biomarkers, respiratory failure, and inflammation were analyzed. Setting: Multicenter study in ICUs. Patients: Critically ill patients with respiratory failure, with coronavirus disease 2019, or without (ICU control). Measurements and Main Results: A total of 27 patients with coronavirus disease 2019 and 19 ICU controls were enrolled. Compared with ICU controls with pneumonia of other etiology, patients with coronavirus disease 2019 had significantly higher glial fibrillary acidic protein (272 pg/mL [150–555 pg/mL] vs 118 pg/mL [78.5–168 pg/mL]; p = 0.0009). In coronavirus disease 2019 patients, glial fibrillary acidic protein (rho = 0.5115, p = 0.0064), ubiquitin carboxy-terminal hydrolase L1 (rho = 0.4056, p = 0.0358), and neurofilament-light chain (rho = 0.6223, p = 0.0005) positively correlated with Intensive Care Delirium Screening Checklist score and were increased in patients with delirium (Intensive Care Delirium Screening Checklist ≥ 4) in the coronavirus disease 2019 group but not in ICU controls. There were no associations between the measures of respiratory function or cytokines with glial fibrillary acidic protein, total tau, ubiquitin carboxy-terminal hydrolase L1, or neurofilament-light chain levels in patients with coronavirus disease 2019. Conclusions: Plasma glial fibrillary acidic protein is two-fold higher in critically ill patients with coronavirus disease 2019 compared with ICU controls. Higher levels of glial fibrillary acidic protein, ubiquitin carboxy-terminal hydrolase L1, and neurofilament-light chain associate with delirium in patients with coronavirus disease 2019. Elevated plasma glial fibrillary acidic protein, ubiquitin carboxy-terminal hydrolase L1, and neurofilament-light chain are independent of respiratory function and peripheral cytokines.
title: Newsletter Institut für Allgemeinmedizin und Palliativmedizin Ausgabe Juni 2022
Creators: name: Medizinische Hochschule Hannover
Publisher: name: Medizinische Hochschule Hannover Bibliothek
Year: 2022
Subjects: subject: 610

description: Newsletter Allgemeinmedizin und Palliativmedizin, vol. 2022, no. 2
Improving a Smartphone Wearable Mobility Monitoring System with Feature Selection and Transition Recognition
Creators: name: Capela, Nicole Alexandra
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Feature Selection
Activity Recognition
Smartphone
Signals

description: Modern smartphones contain multiple sensors and long lasting batteries, making them ideal platforms for mobility monitoring. Mobility monitoring can provide rehabilitation professionals with an objective portrait of a patient’s daily mobility habits outside of a clinical setting. The objective of this thesis was to improve the performance of the human activity recognition within a custom Wearable Mobility Measurement System (WMMS). Performance of a current WMMS was evaluated on able-bodied and stroke participants to identify areas in need of improvement and differences between populations. Signal features for the waist-worn smartphone WMMS were selected using classifier-independent methods to identify features that were useful across populations. The newly selected features and a transition state recognition method were then implemented before evaluating the improved WMMS system’s activity recognition performance. This thesis demonstrated: 1) diverse population data is important for WMMS system design; 2) certain signal features are useful for human activity recognition across diverse populations; 3) the use of carefully selected features and transition state identification can provide accurate human activity recognition results without computationally complex methods.
title: Newsletter Institut für Allgemeinmedizin und Palliativmedizin Ausgabe Dezember 2022
Creators: name: Medizinische Hochschule Hannover
Publisher: name: Medizinische Hochschule Hannover Bibliothek
Year: 2022
Subjects: subject: 610

description: Newsletter Allgemeinmedizin und Palliativmedizin, vol. 2022, no. 3
The Principle of Integration in Sustainable Development Through the Process of Treaty Interpretation: Addressing the Balance Between Consensual Constraints and Incorporation of Normative Environment
Creators: name: Hagiwara, Kazuki
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Sustainable development
International law
Vienna Convention on the Law of Treaties
Treaty interpretation
Environmental law
WTO

description: Considering that the concept of sustainable development has a function of normative integration in international law, Article 31(3)(c) provides a legitimate basis of such systemic integration. At the same time, it displays the limitations of the harmonious solution drawn from its application because it works only within the rigid consent-based framework in which the referenced rules should be legal “rules” and should be “applicable in the relations between the parties.” International jurisprudence suggests supplemental elements to overleap the consensual limitations in the application of Article 31(3)(c): a generic term and the object and purpose of the treaty. These text-based and the object-and-purpose-based developmental interpretative techniques enable interpreters to consider legal rules that are not “any relevant rules of international law applicable in the relations between the parties” under Article 31(3)(c).
title: Newsletter Institut für Allgemeinmedizin und Palliativmedizin Ausgabe Nov 2023
Creators: name: Medizinische Hochschule Hannover
Publisher: name: Medizinische Hochschule Hannover Bibliothek
Year: 2023
Subjects: subject: 610

description: Newsletter Allgemeinmedizin und Palliativmedizin, vol. 2023, no. 2
Preparing for a Safety Evaluation of Rotavirus Vaccine Using Health Services Data in Ontario: The Development of a Diagnostic Algorithm for Intussusception, an Estimation of Baseline Incidence and an Evaluation of Methods
Creators: name: Ducharme, Robin Beverly
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Rotavirus vaccine
Intussusception
Algorithm
Health Services Data
Methodological Review

description: In view of the recent implementation of a publicly funded rotavirus vaccination program in Ontario, we undertook studies to help guide the design of a safety evaluation of the vaccine with respect to intussusception. We used administrative data to develop and validate an algorithm for intussusception, and quantified its incidence in Ontario. We also conducted a systematic review of study designs used to evaluate post-licensure vaccine safety, and discussed each design’s strengths and weaknesses. The validated algorithm for intussusception was sensitive (89.3%) and highly specific (>99.9%). We observed the highest mean incidence (34 / 100,000) in males <1 year of age. While other designs are more robust, the inability to ascertain individual vaccination status from Ontario’s administrative data dictated our selection of an ecological design for safety evaluation of rotavirus vaccine. Data assimilated from this thesis represent a critical step toward the timely evaluation of rotavirus vaccine safety in Ontario.
Le détournement publicitaire sur Internet : quelles sont les influences sur le récepteur?
Creators: name: Faucher, Marie-France
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Internet
Détournement publicitaire
subvertising
effets
publicité
médias sociaux
design quasi expérimental

description: Le détournement publicitaire est une nouvelle pratique par laquelle l’internaute modifie une publicité dans le but, entre autres, de dénoncer, de se moquer ou de s’amuser aux dépens d’un produit ou d’une marque. Cette publicité détournée générée par les utilisateurs (DPGU) peut être propagée via les médias sociaux et atteindre un nombre d’internautes et de visionnements important. Mais influence-t-elle le récepteur? Peut-elle nuire à l’entreprise ou à la marque? Dans le cadre de cette étude quasi expérimentale, nous analysons la cognition envers le DPGU et la cible, c’est-à-dire la compréhension qu’en a le récepteur. Puis, nous mesurons son attitude (niveau d’appréciation) envers le DPGU et la cible. Enfin, nous voyons si ces deux variables modifient l’intention d’acheter des récepteurs. En parallèle, nous nous intéressons à la question de la propagation des DPGU dans la communauté virtuelle.
Supplementary document for Signal properties of split-spectrum amplitude decorrelation angiography for quantitative optical coherence tomography-based velocimetry - 5420487.pdf
Creators: name: Nakamichi, Yu
name: Chiu, Kai-Shih
name: Sun, Chia-Wei
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Uncategorized

description: Supplemental document and figures
Aokana: A GPU-Driven Voxel Rendering Framework for Open World Games
Creators: name: Fang, Yingrong
name: Wang, Qitong
name: Wang, Wei
Publisher: name: arXiv
Year: 2025
Subjects: subject: Graphics (cs.GR)
subject: FOS: Computer and information sciences

description: Voxels are among the most popular 3D geometric representations today. Due to their intuitiveness and ease-of-editing, voxels have been widely adopted in stylized games and low-cost independent games. However, the high storage cost of voxels, along with the significant time overhead associated with large-scale voxel rendering, limits the further development of open-world voxel games. In this paper, we introduce Aokana, a GPU-Driven Voxel Rendering Framework for Open World Games. Aokana is based on a Sparse Voxel Directed Acyclic Graph (SVDAG). It incorporates a Level-of-Details (LOD) mechanism and a streaming system, enabling seamless map loading as players traverse the open-world game environment. We also designed a corresponding high-performance GPU-driven voxel rendering pipeline to support real-time rendering of the voxel scenes that contain tens of billions of voxels. Aokana can be directly applied to existing game engines and easily integrated with mesh-based rendering methods, demonstrating its practical applicability in game development. Experimental evaluations show that, with increasing voxel scene resolution, Aokana can reduce memory usage by up to ninefold and achieves rendering speeds up to 4.8 times faster than those of previous state-of-the-art approaches.
title: MHH - ganz nah! Fünf Tage im Stadtlabor aufhof
Creators: name: Zorn, Stefan
Publisher: name: Medizinische Hochschule Hannover Bibliothek
Year: 2024
Subjects: subject: 610

description: MHHinfo: Das Magazin der Medizinischen Hochschule Hannover, no. 1
Measurement of Stigma and Relationships Between Stigma, Depression, and Attachment Style Among People with HIV and People with Hepatitis C
Creators: name: Cabrera, Christine M.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: HIV Stigma
HCV Stigma
Item Response Theory
Attachment Theory

description: This dissertation is composed of three studies that examined illness-related stigma, depressive symptoms and attachment style among patients living with HIV and Hepatitis C (HCV). The first study examined the psychometric properties of a brief HIV Stigma Scale (B-HSS) in a sample of adult patients living with HIV (PHA) (n=94). The second study developed and explored the psychometric properties of the HCV Stigma Scale in a sample of adult patients living with HCV (PHC) (n =92). Psychometric properties were evaluated with classical test theory and item response theory methodology. The third study explored whether illness-related stigma mediated the relationship between insecure attachment styles (anxious attachment or avoidant attachment) and depressive symptoms among PHA (n =72) and PHC (n=83). From June to December 2008, patients were recruited to participate in a questionnaire study at the outpatient clinics in The Ottawa Hospital. Findings indicated that the 9-item B-HSS is a reliable and valid measure of HIV stigma with items that are highly discriminatory, which indicates that items are highly effective at discriminating patients with different levels of stigma. The 9-item HCV Stigma Scale was also found to be reliable and valid with highly discriminatory items that effectively differentiate PHC. Construct validity for both scales was supported by relationships with theoretically related constructs: depression and quality of life. Among PHA, when HIV stigma was controlled the relationship between anxious attachment style and depression was not significant. However, the relationship between avoidant attachment style and depressive symptoms decreased but remained significant. Among PHC when HCV stigma was controlled the relationship between insecure attachment styles and depressive symptoms was not significant. Dissertation results emphasize the importance of identifying patients experiencing illness-related stigma and the relevance of addressing stigma and attachment style when treating depressive symptoms among PHA and PHC.
Stakeholder Participation in Primary Care System Change: A Case Study Examination of the Introduction of the First Nurse Practitioner-Led Clinic in Ontario
Creators: name: O'Rourke, Tammy
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Stakeholder
Vision
Nurse Practitioner
Change

description: Purpose: To examine stakeholder participation in the primary care system change process that led to the introduction of the first Nurse Practitioner-Led Clinic in Ontario. Design: Qualitative case study guided by the principles of stakeholder and system change theory. Setting: Northern Community in Ontario, Canada. Participants: Purposeful sample of healthcare providers, healthcare managers and health policy stakeholders. Procedures: This case study was bound by place (Sudbury), time (January 2006–January 2008), activity (stakeholder participation), and process (introduction of an innovation, the first Nurse Practitioner-Led Clinic in Ontario, during a primary care system change). Semi-structured individual interviews were conducted with participants who represented the clinic, the local community, and the province. Public documents, such as newspaper articles published during the 2 year time boundary for this case and professional healthcare organization publications, were also examined. Interviews were analyzed using qualitative content analysis and public documents were reviewed for key messages to complement the interview findings. Field notes written during data collection and analysis were used to provide additional depth, contribute insights to the data, and ascribe meaning to the results. Main Findings: Sixteen interviews were conducted with key stakeholders. Twenty public documents which yielded the most specific information relevant to the case study time boundaries and activities were selected and reviewed. Six main themes are reported: felt need, two visions for change (one for a Nurse Practitioner-Led Clinic and one for Family Health Teams [FHTs]), vision processes related to ensuring the visions became or continued to be a reality in Ontario’s healthcare system (shaping, sharing, and protecting the vision), stakeholder activities, and sustaining and spreading the vision. Conclusions: In this case, stakeholder participation influenced policy decisions and was a key contributor to the primary care system change process to introduce the first Nurse Practitioner-Led Clinic in Ontario. Stakeholders are motivated by various needs to engage in activities to introduce an innovation in primary care. One of the most common needs felt by both those who supported the introduction of the first Nurse Practitioner-Led Clinic and those who were opposed to it was the need for improved patient access to primary care.
The epigenomics of sarcoma
Creators: name: Nacev, Benjamin A.
name: Jones, Kevin B.
name: Intlekofer, Andrew M.
name: Yu, Jamie
name: Allis, C. David
name: Tap, William D.
name: Ladanyi, Marc
name: Nielsen, Torsten
Publisher: name: Nature Reviews Cancer
Year: 2021

description: Epigenetic regulation is critical to physiological control of development, cell fate, cell proliferation, genomic integrity, and fundamentally, transcriptional regulation. This epigenetic control occurs at multiple levels including through DNA methylation, histone modification, nucleosome remodeling, and modulation of the three-dimensional chromatin structure. Alterations in genes that encode chromatin regulators are common among mesenchymal neoplasms, a collection of more than 160 tumor types including over 60 malignant variants (sarcomas) that have unique and varied genetic, biological and clinical characteristics. Herein, we review those sarcomas in which chromatin pathway alterations drive disease biology. Specifically, we emphasize examples of dysregulation of each level of epigenetic control though mechanisms that include alterations in metabolic enzymes that regulate DNA methylation and histone posttranslational modifications, mutations in histone genes, subunit loss or fusions in chromatin remodeling and modifying complexes, and disruption of higher-order chromatin structure. Epigenetic mechanisms of tumorigenesis have been implicated in mesenchymal tumors ranging from chondroblastoma and giant cell tumor of bone to chondrosarcoma, malignant peripheral nerve sheath tumor, synovial sarcoma, epithelioid sarcoma and Ewing sarcoma: all aggressive diseases which present in a younger patient population than most cancers. Finally, we review current and potential future approaches for the development of sarcoma therapies based on this emerging understanding of chromatin dysregulation.
Factors associated with the use of supervised consumption facilities among women who inject drugs in a Canadian setting
Creators: name: Ickowicz, Sarah
name: Grant, Cameron
name: Nosova, Ekaterina
name: Boyd, Jade
name: Brar, Rupinder
name: Milloy, M-J
name: Hayashi, Kanna
name: Nolan, Seonaid
name: Milloy, M-J
Publisher: name: The University of British Columbia
Year: 2022

description: Background: Supervised consumption facilities (SCFs) are evidence-based harm reduction interventions that have been shown to reduce the risk of social and health-related harms associated with injection drug use. Previous qualitative studies have highlighted important motivations for SCF use among women who use drugs. However, factors associated with SCF use among women have not previously been evaluated. Methods: Data were obtained from two longitudinal community-recruited cohorts of people who use drugs in Vancouver, Canada between 2003 and 2017. Multivariable generalized estimating equations were used to calculate the odds of SCF use associated with social and structural risk factors for drug-related harm among women who reported injection drug use in the preceding sixmonths. Results: A total of 795 participants were included in the study, contributing to 6302 interviews, with 602 participants (76%) reporting SCF use in at least one interview. Multivariable analysis demonstrated daily heroin and crystal methamphetamine injection (Adjusted Odds Ratio [AOR]=1.32 and 1.65 respectively), injecting in public (AOR=1.77), binge injection (AOR =1.22) and lack of housing (AOR=1.74) to be associated with SCF use. Conclusions: The current study demonstrates higher intensity patterns of drug use, including daily heroin and crystal methamphetamine injection, injecting in public and binge injection, as well as homelessness to be associated with SCF use among women. Future research should identify barriers to SCF use among women to minimize the risk of overdose and other drug-related harms.
title: Ein großer Stratege der Psychiatriereform: Erinnerung an Manfred Bauer
Creators: name: Elgeti, Hermann
name: Haselbeck, Helmut
Publisher: name: Psychiatrie Verlag
Year: 2024
Subjects: subject: 610

description: Sozialpsychiatrische Informationen, vol. 54, no. 2, p. 60
title: NEWSLETTER Gastroenterologie, Hepatologie und Endokrinologie 03/24
Creators: name: Medizinische Hochschule Hannover
Publisher: name: Medizinische Hochschule Hannover Bibliothek
Year: 2024
Subjects: subject: 610

description: NEWSLETTER Gastroenterologie, Hepatologie und Endokrinologie, vol. 2024, no. 3
Elucidating the Biochemical and Structural Features Required for SMYD5 Mediated Methylation of Histone H4 and Other Potential Substrates
Creators: name: Mongeon, Vanessa
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Methylation
SMYD5
Histone
Peptide Array

description: Lysine methylation modulates diverse biological processes and is catalyzed by SET domain methyltransferases such as the SMYDs (SMYD1-5), which possess a SET domain split by a MYND motif. Through association with NCoR, the H4 Lys20 methyltransferase activity of SMYD5 represses inflammation by restricting TLR-4 mediated expression in macrophages, yet biochemical and structural features required for SMYD5 methylation activity remain elusive. To determine how SMYD5 catalyses methylation, crystallization screens were conducted with SMYD5 in complex with the co-factor AdoMet and histone H4. Screens yielded lead conditions but no crystals. To determine the motif recognized by SMYD5 and decipher its methylome, peptide arrays were conducted to produce a methylation motif used to identify putative substrates. Surprisingly, arrays revealed that substitution of Lys16, not Lys20, is detrimental to SMYD5 activity. Further enzymatic assays are required to determine if SMYD5 methylates residues other than Lys20 on the H4 tail, or if structural determinants or interacting partners restrict methylation of target lysines.
Towards Context-based Fatigue Detection System in Vehicular Area Network
Creators: name: Alhazmi, Sultan
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Driver Fatigue Detection

description: Driver fatigue is responsible for up to 30% of fatal car accidents. This issue has been addressed by many scholars in order to save thousands of lives and reduce many costs. The goal of this work is to reduce the number of car accidents caused by mental fatigue or drowsiness. In order to achieve this goal, we propose a personalized Bayesian Network (BN) to detect driver’s fatigue. The detection of driver fatigue is enhanced by combining data that reflects the driver’s performance with context-aware information. The parameters of the system are the angular velocity of the steering wheel, the pressure applied to the gas and brake pedals, the grip force on the steering wheel, weather conditions, current traffic, and time of day. The aforementioned parameters of the network are updated on a regular basis, which makes fatigue detection more reliable. Besides, these parameters allow the system to detect a driver’s fatigue through driving performance which is both individualized and context aware. In our experiment, subjects drove a driving simulator game during six sessions, for a total of one hour. After each session, every subject used the Karolinska Sleepiness Scale (KSS) to rate her fatigue’s level. The system was trained on the data collected separately from each user, allowing BN to be personalized for each subject. The proposed system showed an average accuracy of 96%, and ability to overcome the issue of individual differences and uncertainties which are involved in fatigue detection process.
title: Der Mensch im Mittelpunkt: wie künstliche Intelligenz die Medizin verändert
Creators: name: Zorn, Stefan
Publisher: name: Medizinische Hochschule Hannover Bibliothek
Year: 2024
Subjects: subject: 610

description: MHHinfo: Das Magazin der Medizinischen Hochschule Hannover, no. 2
The Genetic Heterogeneity of Brachydactyly Type A1: Identifying the Molecular Pathways
Creators: name: Racacho, Lemuel Jean
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Human genetics
Mutations
High-throughput sequencing
Cis-regulation
BMP-SMAD
Brachymesophalangies
Copy number variation
Targeted resequencing
IHH
GDF5
BMPR1B
Mendelian disorder

description: Brachydactyly type A1 (BDA1) is a rare autosomal dominant trait characterized by the shortening of the middle phalanges of digits 2-5 and of the proximal phalange of digit 1 in both hands and feet. Many of the brachymesophalangies including BDA1 have been associated with genetic perturbations along the BMP-SMAD signaling pathway. The goal of this thesis is to identify the molecular pathways that are associated with the BDA1 phenotype through the genetic assessment of BDA1-affected families. We identified four missense mutations that are clustered with other reported BDA1 mutations in the central region of the N-terminal signaling peptide of IHH. We also identified a missense mutation in GDF5 cosegregating with a semi-dominant form of BDA1. In two families we reported two novel BDA1-associated sequence variants in BMPR1B, the gene which codes for the receptor of GDF5. In 2002, we reported a BDA1 trait linked to chromosome 5p13.3 in a Canadian kindred (BDA1B; MIM %607004) but we did not discover a BDA1-causal variant in any of the protein coding genes within the 2.8 Mb critical region. To provide a higher sensitivity of detection, we performed a targeted enrichment of the BDA1B locus followed by high-throughput sequencing. We report the identification of a novel 9.5 Kb intergenic tandem duplication in two unrelated BDA1-affected families. In-vitro and in-vivo reporter assays demonstrated the enhancer activity of noncoding conserved sequence elements found within the microduplication. We also show an upregulation of the neighboring genes, NPR3 and PDZD2, in the patients' fibroblasts that suggests a gain-of-function through the duplication of cis-regulatory elements on dose sensitive genes. By expanding the repertoire of BDA1-causing mutations in IHH, GDF5, BMPR1B and at the BDA1B locus, we have begun to elucidate a common genetic pathway underlying phalangeal formation and elongation.
Supplementary document for Light-Sheet Fluorescence Microscopy for the in vivo study of microtubule dynamics in the zebrafish embryo - 5420919.pdf
Creators: name: Bernardello, Matteo
name: marsal, maria
name: Manzano, Emilio Gualda
name: Loza-Alvarez, Pablo
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Supplement 1
Active Video Games and Energy Balance in Male Adolescents
Creators: name: Gribbon, Aidan
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Exergaming
Appetite
Energy intake
Energy expenditure
Food
Obesity
Teenagers

description: Active video games (AVG) have been shown to acutely increase energy expenditure when compared to seated video games; however, the compensatory effects on energy intake and subsequent energy expenditure are largely unknown. The main objective of this thesis was to examine the acute effects of AVG on energy intake and expenditure in male adolescents. Our results suggest that male adolescents compensate for one hour of AVG play by decreasing their physical activity levels for the remainder of the day. There was no compensation in acute energy intake with AVG play. The results from this thesis suggest that the benefits of one hour of Kinect™ AVG play are offset within 24 hours in male adolescents. Therefore, caution must be exercised when prescribing AVG for interventions aimed at preventing/treating childhood obesity.
title: NEWSLETTER Gastroenterologie, Hepatologie und Endokrinologie 06/24
Creators: name: Medizinische Hochschule Hannover
Publisher: name: Medizinische Hochschule Hannover Bibliothek
Year: 2024
Subjects: subject: 610

description: NEWSLETTER Gastroenterologie, Hepatologie und Endokrinologie, vol. 2024, no. 6
title: Der Weg aus der Stille: seit 40 Jahren: Hören dank Cochlea Implantaten
Creators: name: Zorn, Stefan
Publisher: name: Medizinische Hochschule Hannover Bibliothek
Year: 2024
Subjects: subject: 610

description: MHHinfo: Das Magazin der Medizinischen Hochschule Hannover, no. 3
The Effects of Aerobic and Resistance Exercise Training on the Cardiometabolic Health of Adolescents with Obesity
Creators: name: Alberga, Angela S.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Obesity
Adolescent
Physical activity
Exercise
Body composition
Fitness
Overweight
Aerobic training
Resistance training
Cardiovascular disease risk markers
Musculoskeletal

description: Physical inactivity and obesity in adolescence are associated with an increased risk of cardiovascular disease (CVD). Although exercise is recommended for the management of obesity, we know little about which types of exercise training are the most effective in reducing excess body fat and improving CVD risk in obese adolescents. This dissertation examined the effects of aerobic training, resistance training and their combination on the cardiometabolic health (body composition, CVD risk markers, resting metabolic rate (RMR), and fitness) of obese adolescents who participated in the Healthy Eating Aerobic and Resistance Training in Youth (HEARTY) trial. After a 4-week supervised moderate-intensity exercise run-in period, 304 overweight and obese adolescents were randomized to 4 groups for 22 weeks: Aerobic training, Resistance training, Combined aerobic and resistance exercise training, or a non-exercising Control. All four groups received dietary counseling designed to promote healthy eating with a maximum daily energy deficit of 250 kcal. Participants were assessed at baseline and after 3 and 6 months. Body composition was assessed using magnetic resonance imaging. Blood tests for traditional and non-traditional CVD risk markers were measured after a 12-hour fast. RMR and cardiorespiratory fitness were assessed using indirect calorimetry at rest and during a maximal treadmill test respectively. Musculoskeletal fitness (muscular strength, endurance, flexibility) was assessed using eight repetition maximum tests (8-RM) on the leg press, chest press and upright row machines and using the Canadian Society for Exercise Physiology- Canadian Physical Activity Fitness and Lifestyle Appraisal (CSEP-CPAFLA) tests for grip strength, push-ups, sit-ups, sit and reach and vertical jump. Decreases in percent body fat and abdominal fat were greatest in the combined training group. Although body weight, RMR and traditional CVD risk markers did not improve following the exercise intervention, the combined training group showed improvements in cardiorespiratory and musculoskeletal fitness and some non-traditional CVD risk markers. Cumulatively, combined aerobic and resistance exercise training showed the greatest improvements in cardiometabolic health in overweight and obese adolescents. This thesis concludes with a knowledge translation article detailing the practical lessons learned from exercise interventions with obese youth with hopes of increasing adherence to future exercise programs and improving the overall health of children and adolescents with obesity.
Omnidirectional High Dynamic Range Imaging with a Moving Camera
Creators: name: Zhou, Fanping
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: High dynamic rang imaging
multi-view HDR
spherical image

description: Common cameras with a dynamic range of two orders cannot reproduce typical outdoor scenes with a radiance range of over five orders. Most high dynamic range (HDR) imaging techniques reconstruct the whole dynamic range from exposure bracketed low dynamic range (LDR) images. But the camera must be kept steady with no or small motion, which is not practical in many cases. Thus, we develop a more efficient framework for omnidirectional HDR imaging with a moving camera. The proposed framework is composed of three major stages: geometric calibration and rotational alignment, multi-view stereo correspondence and HDR composition. First, camera poses are determined and omnidirectional images are rotationally aligned. Second, the aligned images are fed into a spherical vision toolkit to find disparity maps. Third, enhanced disparity maps are used to warp differently exposed neighboring images to a target view and an HDR radiance map is obtained by fusing the registered images in radiance. We develop disparity-based forward and backward image warping algorithms for spherical stereo vision and implement them in GPU. We also explore some techniques for disparity map enhancement including a superpixel technique and a color model for outdoor scenes. We examine different factors such as exposure increment step size, sequence ordering, and the baseline between views. We demonstrate the success with indoor and outdoor scenes and compare our results with two state-of-the-art HDR imaging methods. The proposed HDR framework allows us to capture HDR radiance maps, disparity maps and an omnidirectional field of view, which has many applications such as HDR view synthesis and virtual navigation.
Analysis of Potential DNA Insulators in Arabidopsis thaliana
Creators: name: Rasooli, Lara
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014

description: The control of transgene expression is the key to producing transgenic organisms with beneficial traits; however, the prevention of transgene misexpression in transformed organisms has been a recurring challenge and may lead to the expression of undesirable traits. Insulators are DNA sequences that regulate gene expression through their interaction with protein factors. They function as cis-acting DNA sequences with the ability to act as enhancer-blocking elements or barrier elements, or both depending on the molecular mechanism. The functions of insulators have been tested using a model system based upon transgenic Arabidopsis thaliana plants to determine the expression of transgenes and to decrease non-specific interactions resulting in misexpression. To date, various insulators have been identified in invertebrates and vertebrates but few have been discovered and analyzed in plants. This study aims to identify insulators that can function to block enhancer-promoter interactions in transgenic plants preventing transgene misexpression. An oligonucleotide library was produced allowing for subsequent screening of putative insulators. Screening of recombinant clones was initiated to identify strong insulator candidates using vectors with different promoter/reporter systems in Arabidopsis. To date, three insulators (CLOI-3, CLOII-10, and CLOII-12) have been identified as candidate insulators that block enhancer-promoter interaction. The CLOI-3 insulator has been further analyzed through the introduction of deletions to identify crucial regions. Two replicates for both CLOII-10 and CLOII-12 indicate possible insulator activity. By characterizing new insulator sequences we will be able to further understand the mechanisms involved in gene expression and apply them to transgenic research involving other biological systems, ultimately addressing important issues such as crop development.
Marianne and Columbia in Arms: The Franco-American Relationship During the First World War
Creators: name: Sonego, Daniel
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: First World War
France-United States relations

description: The First World War was the United States’ first significant foray into European conflict and their first war as part of a major international coalition. The inadequacy of the US Army for the conflict forced them to rely on extensive support from its allies to successfully prosecute the war. For most members of the American Expeditionary Force (AEF), the ally with which they most closely associated with was France who provided substantial amounts of equipment, training, and guidance. Most work on bilateral Franco-American relations during the period focus on high level diplomatic and military relations between the leaders of both nations and casts the state of relations as being antagonistic. This paper examines the more mundane experiences of AEF members with French soldiers and civilians and how those experiences shaped American views of themselves and their allies. By examining the American relationship with the French on and off the battlefield, it provides a view of the alliance outside of the staterooms and war rooms and re-examines previous characterisations of the relationship. The first chapter examines American relations with French civilians in port towns, in billets, and on leave through the opinions and behaviour of members of the AEF. The second and third chapter focus on the relationship with the French military not only through American opinions about the military competence of their ally but also examines the development of an American military identity apart from and in opposition to the French. American experience in the war allowed Americans not only to form stronger relationships than generally acknowledged with the French but also allowed them to develop a stronger sense of their own identity as a people and a country.
Biological Confinement of Zebrafish Using RNAi
Creators: name: Boratynska, Susan
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: RNAi
dnd
Zebrafish

description: The increasing demand for fish in the food industry has resulted in the extensive overfishing of wild fisheries. In efforts to alleviate the demand from the food industry, genetically modified (GM) fish were developed possessing traits such as larger mass, faster growth, and increased resistance to disease. However, the greater fitness advantage of GM fish presents potential risks for wild type populations in the event of release or escape from a confined fish facility. In addition to physical barriers, it is critical to develop a genetic mechanism in order to ensure that the spread of GM transgene to the natural populations does not occur. RNA interference (RNAi) is an endogenous mechanism used to regulate gene expression by destroying targeted mRNA molecules. Manipulation of this biological process has been successfully utilized to knockdown specific genes through the introduction of synthetic transgenes in organisms such as C. elegans, M. musculus, and D. melanogaster. Although the use of RNAi as a biological tool is still relatively new in zebrafish, recent work has explored elements of this mechanism allowing for greater knockdown efficiencies. The deadend (dnd) gene is required for primordial germ cell (PGC) development and survival. Previous studies have shown that zebrafish dnd knockouts develop into sterile adults without disrupting somatic development. In efforts to induce sterility in zebrafish, short hairpin RNA (shRNA) constructs targeting dnd were designed to exploit the endogenous RNAi pathway. Upon qualitative analysis in transient and transgenic zebrafish subjected to the synthetic RNAi construct, a reduction in the germ cell population at early stages of development was observed. However, quantification of dnd mRNA in fish from the same time points did not show significant changes in expression levels compared to their wildtype counterparts. Adult fish subjected to the transgene construct produced viable gametes. The use of RNAi as a tool for bioconfinement relies on sterility among all individuals subjected to the shRNA bearing transgene. Based on the results obtained, the verdict is still unclear as to whether shRNA is a viable mechanism for large scale bioconfinement.
Becoming Taiwanese: Negotiating Language, Culture and Identity
Creators: name: Chen, Ying-Chuan
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Taiwanese identity
language
hegemony
Mandarin
schooling
oral history
Kuomintang
Taiwan history

description: Between 1945 and 1987, as part of its efforts to impose a Chinese identity on native-born Taiwanese and to establish and maintain hegemony, Chiang Kai-shek’s Kuomintang (KMT) government pursued a unilingual, Mandarin-only policy in education. This thesis studies the changing meaning of “becoming Taiwanese” by examining the school experiences of four generations of Taiyu speakers who went to school during the Mandarin-only era: 1) those who also went to school under the Japanese; 2) those who went to school before 1949 when Taiwan was part of KMT-controlled China; 3) those who went to school during the 1950s at the height of the implementation of KMT rule; and, 4) those who went to school when Mandarin had become the dominant language. Two data types, interviews and public documents, are analyzed using two research methods, focus group interviews as the primary one, and document analysis as the secondary one. This research found that there is no direct relationship between how people negotiated language, hegemony and Taiwanese identity. First, as KMT hegemony became more secure, people’s links to their home language became weaker, so their view of Taiwanese identity as defined by Taiyu changed. Second, as exposure to hegemonic forces deepened over time, people were less able to find cultural spaces that allowed escape from hegemonic influences, and this, along with other life-course factors such as occupation, had an impact on their contestations of language and identity. The study recognizes the role of human agency and highlights the interactive and performative aspects of identity construction. The results reflect the different possibilities of living with hegemony in different eras, and also show that Taiwanese identity is not fixed, nor is there a single, “authentic” Taiwanese identity.