cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Sequential Targeting of CD52 and TNF Allows Early Minimization Therapy in Kidney Transplantation
title: From a Biomarker to Targeting in a Proof-Of-Concept Trial
titleType: Subtitle
Creators: name: Viklicky, Ondrej
name: Hruba, Petra
name: Tomiuk, Stefan
name: Schmitz, Sabrina
name: Gerstmayer, Bernhard
name: Sawitzki, Birgit
name: Miqueu, Patrick
name: Mrazova, Petra
name: Tycova, Irena
name: Svobodova, Eva
name: Honsova, Eva
name: Janssen, Uwe
name: Volk, Hans-Dieter
name: Reinke, Petra
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background There is high medical need for safe long-term immunosuppression monotherapy in kidney transplantation. Selective targeting of post-transplant alloantigen-(re)activated effector-T cells by anti-TNF antibodies after global T cell depletion may allow safe drug minimization, however, it is unsolved what might be the best maintenance monotherapy. Methods In this open, prospective observational single-centre trial, 20 primary deceased donor kidney transplant recipients received 2x20 mg Alemtuzumab (d0/d1) followed by 5 mg/kg Infliximab (d2). For 14 days all patients received only tacrolimus, then they were allocated to either receive tacrolimus (TAC, n = 13) or sirolimus (SIR, n = 7) monotherapy, respectively. Protocol biopsies and extensive immune monitoring were performed and patients were followed-up for 60 months. Results TAC-monotherapy resulted in excellent graft survival (5yr 92%, 95%CI: 56.6–98.9) and function, normal histology, and no proteinuria. Immune monitoring revealed low intragraft inflammation (urinary IP-10) and hints for the development of operational tolerance signature in the TAC- but not SIR-group. Remarkably, the TAC-monotherapy was successful in all five presensitized (ELISPOT+) patients. However, recruitment into SIR-arm was stopped (after n = 7) because of high incidence of proteinuria and acute/chronic rejection in biopsies. No opportunistic infections occurred during follow-up. Conclusions In conclusion, our novel fast-track TAC- monotherapy protocol is likely to be safe and preliminary results indicated an excellent 5-year outcome, however, a full–scale study will be needed to confirm our findings. Trial Registration EudraCT Number: 2006-003110-18
Three essays on the effects of the Affordable Care Act on insurance coverage, health, and cost of coverage
Creators: name: Oyeka, Onyinye
Publisher: name: University of Iowa
Year: 2025
Subjects: public abstract

description: One of the goals of the Patient Protection Affordable Care Act was to improve access to affordable coverage by creating the HIMs, mandating coverage, and expanding Medicaid eligibility. However, federal legislative and regulatory changes have led to rising premiums, insurer exit, and disenrollment from the health insurance marketplaces (HIM). Public health and economic crises during the pandemic may have reversed the health gains through Medicaid expansion. In this dissertation, I empirically examine factors that may have contributed to declining enrollment, health, and affordability of coverage. Specifically, in the first study, I employ a difference-differences and synthetic control methods model to examine the effect of the state-based individual mandate on insurance coverage and enrollment. In the second study, I assess the protective effects of the Medicaid expansion on adverse mental health during the pandemic using a difference-in-differences model. In the third paper, I use a difference-in-differences and synthetic control method to examine the effect of the section 1332 reinsurance program on premiums and insurer participation.
Sund og cykelvenlig skolevej
Creators: name: Jensen, Henriette
Publisher: name: Proceedings from the Annual Transport Conference at Aalborg University
Year: 2012

description: Kræftens Bekæmpelse har udgivet en cykelmanual ”Sund og cykelvenlig skolevej – manual med idéer til sund og aktiv transport”. Manualen sætter fokus på, hvordan kommuner, gennem strukturel forebyggelse, kan gøre cykling til den sundeste, sikreste og letteste transport til og fra skole. I manualen gives eksempler og idéer på strukturelle tiltag, der fremmer den aktive transport til og fra skole. Tiltagene er valgt ud fra løsninger, som er realistiske og effektive. Der er ikke omtalt de meget dyre anlægsprojekter. Tværtimod er flere af løsningerne ret billige og kan derfor umiddelbart implementeres mange steder. Gode skoleveje er en forudsætning for at flere børn kan færdes på egen hånd til og fra skole. Manualen er målrettet kommunerne således, at det bliver nemmere at skabe sunde og cykelvenlige skoleveje og dermed motivere flere børn og unge til at cykle mere. Hensigten er, for det første, at argumentere for at det er vigtigt at arbejde med strukturel forebyggelse, og for det andet, at skabe et overblik over området og samtidig give konkret inspiration til handling. Hidtil har der primært været fokus på, hvordan forskellige forbedringer i infrastruktur medførte nedgang i antallet af ulykker, hvilket den nye cykelmanual også bærer præg af. I fremtiden vil det være lige så vigtigt at have fokus på, hvor mange flere vi kan få til at cykle til og fra skole ved at lave intelligente løsninger.
description: Proceedings from the Annual Transport Conference at Aalborg University, Vol. 1 No. 1 (2012): Proceedings from the Annual Transport Conference at Aalborg University
Internationale Trends der UVP- und SUP-Forschung und -Praxis
Creators: name: Rehhausen, Anke
name: Günther, Markus
name: Odparlik, Lisa
Publisher: name: My University
Year: 2018
Subjects: subject: Umweltprüfung
subject: Umweltverträglichkeitsprüfung
subject: Strategische Umweltprüfung
subject: UVP
subject: SUP
subject: Nachhaltigkeit | Strategien | Internationales

description: Die Studie "Internationale Trends der ⁠UVP⁠- und SUP-Forschung und -Praxis" fasst den aktuellen Stand der vor allem in englischsprachigen Fachzeitschriften laufenden Fachdiskussionen im Themenfeld Umweltprüfungen zusammen und zeigt darüber hinaus ausländische Beispiele guter fachlicher Praxis bei Umweltverträglichkeitsprüfungen und Strategischen Umweltprüfungen auf. Die Studie dient dem Wissenstransfer und benennt Forschungs- und Implementierungsbedarfe für Deutschland.
Thrombopoiesis is spatially regulated by the bone marrow vasculature
Creators: name: Stegner, David
name: Van Eeuwijk, Judith M. M.
name: Angay, Oğuzhan
name: Gorelashvili, Maximilian G.
name: Semeniak, Daniela
name: Pinnecker, Jürgen
name: Schmithausen, Patrick
name: Meyer, Imke
name: Friedrich, Mike
name: Dütting, Sebastian
name: Brede, Christian
name: Beilhack, Andreas
name: Schulze, Harald
name: Nieswandt, Bernhard
name: Heinze, Katrin G.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: hematopoietic stem-cells
subject: in-vivo
subject: megakaryocyte migration
subject: platelet-aggregation
subject: integrin activation
subject: thrombus formation
subject: mice
subject: biogenesis
subject: niches
subject: identification
subject: molecular medicine
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: In mammals, megakaryocytes (MKs) in the bone marrow (BM) produce blood platelets, required for hemostasis and thrombosis. MKs originate from hematopoietic stem cells and are thought to migrate from an endosteal niche towards the vascular sinusoids during their maturation. Through imaging of MKs in the intact BM, here we show that MKs can be found within the entire BM, without a bias towards bone-distant regions. By combining in vivo two-photon microscopy and in situ light-sheet fluorescence microscopy with computational simulations, we reveal surprisingly slow MK migration, limited intervascular space, and a vessel-biased MK pool. These data challenge the current thrombopoiesis model of MK migration and support a modified model, where MKs at sinusoids are replenished by sinusoidal precursors rather than cells from a distant periostic niche. As MKs do not need to migrate to reach the vessel, therapies to increase MK numbers might be sufficient to raise platelet counts.
Integreret cykelplanlægning i Aalborg for pendlere, turister og børn
Creators: name: Nielsen, Anne Marie Lautrup
Publisher: name: Proceedings from the Annual Transport Conference at Aalborg University
Year: 2012

description: Aalborg Kommune har siden september 2008 deltaget i EU projektet CIVITAS ARCHIMEDES. Projektet har givet Aalborg Kommune en unik mulighed for at sætte særligt fokus på cyklismen og skabe gode forhold for cyklister gennem en række tiltag. I denne artikel præsenteres tre af de centrale projekter, der alle har haft målsætninger om at få flere op på cyklen ved at arbejde specifikt med projekter målrettet særlige grupper. Projekterne omfatter en cykelpendlerrute til Universitet, bycykler og en ”cykle til skole” kampagnen. Artiklen vil indeholde en præsentation af projekterne og deres koncept, samtidig med at resultater også vil blive præsenteret. Endelig vil der blive reflekteret over udbyttet af projekterne og de fremtidige planer for cykelplanlægning i Aalborg Kommune.
description: Proceedings from the Annual Transport Conference at Aalborg University, Vol. 1 No. 1 (2012): Proceedings from the Annual Transport Conference at Aalborg University
Light-induced reflectivity transients in black-Si nanoneedles
Creators: name: Ščajev, P.
name: Malinauskas, T.
name: Seniutinas, G.
name: Arnold, M. D.
name: Gentle, A.
name: Aharonovich, I.
name: Gervinskas, G.
name: Michaux, P.
name: Hartley, J. S.
name: Mayes, E. L.H.
name: Stoddart, Paul
name: Juodkazis, Saulius
Publisher: name: Swinburne
Year: 2024

description: The change in reflectivity of black-Si (b-Si) upon optical excitation was measured by the pump-probe technique using picosecond laser pulses at 532 (pump) and 1064 nm (probe) wavelengths. The specular reflection from the random pattern of plasma-etched b-Si nano-needles was dominated by the photo-excited free-carrier contribution to the reflectivity. The kinetics of the reflectivity were found to be consistent with surface structural and chemical analysis, performed by scanning and transmission electron microscopy, and spectroscopic ellipsometry. The surface recombination velocity on the b-Si needles was estimated to be ~102cm/s. Metalization of b-Si led to much faster recombination and alteration of reflectivity. The reflectivity spectra of random b-Si surfaces with different needle lengths was modeled by a multi-step refractive index profile in the Drude formalism. The dip in the reflectivity spectra and the sign reversal in the differential reflectivity signal at certain b-Si needle sizes is explained by the model.
Development of a novel shuttle system for the transfer of gonococcal genes between Escherichia coli and Neisseria gonorrhoeae.
Creators: name: Gauthier, Benoit R.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Biology, Molecular.

description: The objective of this project was to construct a shuttle vector for the transfer of gonococcal genes between Escherichia coli and Neisseria gonorrhoeae using an in vitro-derived deletion derivative of the penicillinase-producing plasmid of N. gonorrhoeae. The ability of N. gonorrhoeae strain F62 to selectively acquire a 1.5 kb TagI fragment derived from the 4.2 kb cryptic plasmid was confirmed by uptake experiments. Neither the 1.5 kb fragment nor the oligonucleotide had any effect on the ability of chromosomal DNA to transform a strain that did not recognize the 1.5 kb fragment. However, the efficiency of transformation of the strain that did acquire the fragment was lowered by the presence of the two competing DNAs. Conjugation, using pUB307, an IncP conjugative plasmid, was the most efficient method for introducing plasmid DNA into recipient gonococci. Deletion derivatives of pJD8 (smallest deletion derivative of pJD4) were constructed in order to reduce the size of pJD8 to the smallest mobilizable plasmid. Plasmid pGRY4 was chosen as a basis for the construction of a shuttle vector. The lacZ complementation system of E. coli and the xy1E system from Pseudomonas putida were investigated as possible positive selection markers for the shuttle vector. Several problems were encountered when the proC gene of N. gonorrhoeae was cloned into pGCY1. Future transformation attempts should be performed in a restriction$\sp-$ and recA$\sp-$ strain. (Abstract shortened by UMI.)
What do US and Canadian parents do to encourage or discourage physical activity among their 5-12 Year old children?
Creators: name: Tu, Andrew W.
name: O’Connor, Teresia M.
name: Beauchamp, Mark R. (Mark Robert), 1972-
name: Hughes, Sheryl O.
name: Baranowski, Tom
name: Mâsse, Louise C.
Publisher: name: BioMed Central
Year: 2017

description: Background: Parents have the potential to substantively influence their child’s physical activity. This study identified the parenting practices of US and Canadian parents to encourage or discourage their 5-12 year-old child’s physical activity and to examine differences in parenting practices by country, parental sex, age of child, and income. Methods: The sample consisted of 134 US and Canadian parents (54.5% US; 60.4% female) recruited from a web-based panel by a polling firm. The parents answered open-ended questions about what they and other parents do to encourage or discourage their child to be active. Responses were coded using a scheme previously developed to code items used in the published literature. Coded responses were summarized by domain and dimension with differences in responses by country, parental sex, age of child, or household income assessed with a log-linear analysis. Results: The 134 parents provided 649 and 397 responses to ways that parents encourage or discourage their child’s physical activity, respectively. Over 70% of responses for practices that encourage physical activity were related to structure of the environment, parental encouragement, and co-participation. The most common response was co-participation in activity with the child. Of the practices that discourage physical activity, 67% were related to structure of the environment, lack of parental control, and modeling poor behaviors. The most common response was allowing screen time. There were no differences in response by country, parental sex, child age, or household income. Conclusions: Parents most often encouraged physical activity through structure and emotional support and discouraged physical activity through lack of structure and control. Understanding how parents influence their child’s physical activity may help improve intervention strategies. The current results will inform the development of a physical activity parenting practices instrument.
Hepatic distribution of alpha- and beta-adrenoceptors in trout: Effects of cortisol and temperature.
Creators: name: Dugan, Stephen George.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Biology, Animal Physiology.

description: Exposure of an organism to a stressor results in a primary stress response. A part of this response involves the release of the catecholamines, epinephrine and norepinephrine, which exert their actions by binding to specific membrane binding sites or receptors termed adrenergic receptors or adrenoceptors. Two adrenoceptor types exist on hepatic membranes, and their occupation results in significant changes in the biochemistry of the hepatocyte. The distribution of $\alpha\sb1$- and $\beta\sb2$-adrenoceptors on hepatic membranes is known to be species specific, and also seasonally dependent in cardiac tissue. This study tests the hypothesis that $\alpha$- and $\beta$-adrenoceptor distribution can be modified by cortisol and long term temperature acclimation. Rainbow trout (Oncorhynchus mykiss) were injected with slow release hydrogenated coconut oil implants alone (sham) or containing cortisol for 10-14 days to elevate plasma cortisol levels. Hepatic membranes were purified on discontinuous sucrose gradients and $\alpha$- and $\beta$-adrenoceptors were assayed from sham and cortisol injected trout as well as non-injected (naive) trout. No significant differences were found between any of the experimental groups for either the affinity $\rm(K\sb{d})$ or receptor number $\rm(B\sb{max})$ values of both receptor types. Cortisol treatment resulted in no change in either hepatic membrane phospholipid composition or plasma glucose, although plasma lactate decreased in cortisol injected fish. Adrenoceptor function was tested by examining glycogenolysis in isolated hepatocytes from sham and cortisol injected rainbow trout. Epinephrine significantly stimulated glucose release in sham injected trout only. This effect was blocked by both $\alpha$- and $\beta$-antagonists. In addition, studies on trout acclimated to 5 and 20$\sp\circ$C did not demonstrate different receptor characteristics. These studies do not support the hypothesis that rainbow trout exposed to cortisol alter properties of hepatic adrenoceptors.
Miljø og godstransport – miljø og klima som konkurrenceparameter for transport og logistikvirksomheder.
Creators: name: Dagnæs, Lars
Publisher: name: Proceedings from the Annual Transport Conference at Aalborg University
Year: 2012

description: Der er stigende fokus på virksomhedernes muligheder for at reducere emissionerne fra transporterne fra det eksterne godstransportarbejde. Baggrunden herfor er en række udviklingstendenser: • I takt med udviklingen af de vedvarende energikilder og i takt med, at energiforbrug til produktion og opvarmning falder, tegner transport sig for en stadig større andel af den samlede CO2 emissioner. Der vil således også på politisk niveau være stigende fokus på mulighederne for at effektivisere energiforbruget ved transport. I EU er luftfartsektoren fra 2012 inddraget i kvotesystemet, og i Frankrig vil det fra 2013 være lovpligtigt for transportbranchen at dokumentere deres emissioner fra deres aktiviteter. • Stadigt flere virksomheder har fokus på de samlede emissioner fra deres aktiviteter og stadigt flere virksomheder laver klimaregnskaber. Her er der stadig større fokus på at inddrage den samlede forsyningskæde. Tendensen er, at virksomheder, som inddrager ”scope 3” i forsyningskæden vælger transport som en af de områder, der fokuseres på. • Udviklingen som beskrevet ovenfor følges op, af en lang række aktiviteter med sigte på at understøtte virksomhedernes arbejde med at opgøre deres emissioner fra transport . På europæisk plan er der således et arbejde i gang med sigte på at fastlægge en europæiske standard for at opgøre og deklarere energiforbrug og GHG emissioner fra transport. Set fra Danmark, er det vigtigt, at danske virksomheder udvikler strategier for deres arbejde med miljø og transport. Målet er at udvikle og fastholde virksomhedernes konkurrenceevne i et globalt marked samtidigt med, at de bidrager til at de samlede emissioner fra transport reduceres.
description: Proceedings from the Annual Transport Conference at Aalborg University, Vol. 1 No. 1 (2012): Proceedings from the Annual Transport Conference at Aalborg University
CBlog – et grænseoverskridende logistiksamarbejde
Creators: name: Schmidt, Claus
name: Dagnæs, Lars
Publisher: name: Proceedings from the Annual Transport Conference at Aalborg University
Year: 2012

description: Grænsen mellem Sønderjylland og Slesvig-Holsten er i dag Danmarks vigtigste port for godstransport med bil og bane. I takt med væksten i Danmarks internationale samhandel op gennem det 20’århundrede er transport er logistikerhvervet i Region Syddanmark vokset. I Tyskland er transport og logistik udpeget som et væksterhverv. Der er en tæt forbindelse mellem transport og logistikvirksomheder nord og syd for grænsen. CB-log, Cros Border Logistics, er udviklet som et 3 årigt projekt med sigte på at Region Slesvig og Region Syddanmark udvikles som en samlet grænseoverskridende logistikregion. En række forskellige aktiviteter har skullet sikre, at der gennem den 3 årige projektperiode fra 2009 til 2012, er skabt grundlag for den fortsatte udvikling af transport og logistik som en samlet styrkeposition for CB-log regionen. Hovedaktiviteterne i projektet har været: 1. Analyse – 2. Projektudvikling og vidensoverførsel – 3. Synliggørelse og markedsføring – 4. Dansk-Tysk tænketank. Projektet afsluttes efteråret 2012 og det etablerede netværk videreføres af UdviklingsRåd Sønderjylland og WIREG1. De vigtigste resultater fra CB-log projektet har været: • Først og fremmest er ”CB-log” etableret som logistikregion og samarbejdsforum internt i regionen • Samlet datamateriale om regionen og dens udviklingspotentiale • Udvikling af de grænseoverskridende netværk i regionen • De mange aktiviteter har synliggjort ”grænseoverskridende transport og logistik” som udviklingspotentiale • Ny markedsføringsplatform for CB-log regionen • En struktur for det fortsatte samarbejde • Konkrete innovationsprojekter på vej
description: Proceedings from the Annual Transport Conference at Aalborg University, Vol. 1 No. 1 (2012): Proceedings from the Annual Transport Conference at Aalborg University
What systemic factors contribute to collaboration between primary care and public health sectors? An interpretive descriptive study
Creators: name: Wong, Sabrina T.
name: MacDonald, Marjorie
name: Martin-Misener, Ruth
name: Meagher-Stewart, Donna
name: O’Mara, Linda
name: Valaitis, Ruta K.
Publisher: name: BioMed Central
Year: 2017

description: Background: Purposefully building stronger collaborations between primary care (PC) and public health (PH) is one approach to strengthening primary health care. The purpose of this paper is to report: 1) what systemic factors influence collaborations between PC and PH; and 2) how systemic factors interact and could influence collaboration. Methods: This interpretive descriptive study used purposive and snowball sampling to recruit and conduct interviews with PC and PH key informants in British Columbia (n = 20), Ontario (n = 19), and Nova Scotia (n = 21), Canada. Other participants (n = 14) were knowledgeable about collaborations and were located in various Canadian provinces or working at a national level. Data were organized into codes and thematic analysis was completed using NVivo. The frequency of “sources” (individual transcripts), “references” (quotes), and matrix queries were used to identify potential relationships between factors. Results: We conducted a total of 70 in-depth interviews with 74 participants working in either PC (n = 33) or PH (n = 32), both PC and PH (n = 7), or neither sector (n = 2). Participant roles included direct service providers (n = 17), senior program managers (n = 14), executive officers (n = 11), and middle managers (n = 10). Seven systemic factors for collaboration were identified: 1) health service structures that promote collaboration; 2) funding models and financial incentives supporting collaboration; 3) governmental and regulatory policies and mandates for collaboration; 4) power relations; 5) harmonized information and communication infrastructure; 6) targeted professional education; and 7) formal systems leaders as collaborative champions. Conclusions: Most themes were discussed with equal frequency between PC and PH. An assessment of the system level context (i.e., provincial and regional organization and funding of PC and PH, history of government in successful implementation of health care reform, etc) along with these seven system level factors could assist other jurisdictions in moving towards increased PC and PH collaboration. There was some variation in the importance of the themes across provinces. British Columbia participants more frequently discussed system structures that could promote collaboration, power relations, harmonized information and communication structures, formal systems leaders as collaboration champions and targeted professional education. Ontario participants most frequently discussed governmental and regulatory policies and mandates for collaboration.
Existing and prospective international legal restrictions on the military use of outer space.
Creators: name: MacDonald, Steven D.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Law.

description: The thesis seeks to ascertain the extent of international legal (primarily treaty) constraints on the military use of outer space. These are to be found for the most part in the multilateral 1963 Partial Test Ban and 1967 Outer Space Treaties and in the bilateral U.S.-Soviet 1972 ABM Treaty. The thesis assesses the compatibility of all feasible near- and mid-term military uses of outer space with these treaties. Alternative interpretations of various provisions are assessed. The thesis contains an especially long and detailed analysis of one particular interpretation dispute under the ABM Treaty--that which concerns the treaty's effect on the development and testing of mobile ABM systems and components based on exotic technologies such as laser and particle beams. Prior to, and in the course of, assessing the evidence bearing upon this issue, the thesis examines the international law that governs the interpretation of treaties generally and the ABM Treaty in particular. The applicability of the 1969 Vienna Convention on the Law of Treaties and of the jurisprudence of the Permanent Court of International Justice and the International Court of Justice to the interpretation of the ABM Treaty is considered. The thesis concludes by assessing the desirability and feasibility of several proposed improvements to the international legal regime governing the military use of outer space.
Lepton Flavour Violation in the Left Right Symmetric Model and the Higgs Triplet Model
Creators: name: Kordiaczyńska, Magdalena
Publisher: name: Zenodo
Year: 2018

description: Introduction to the Higgs Triplet Model (HTM) and Left-Right Symmetric Model (LRSM) and analysis of LFV processes and collider signals within those models. The seminar has been presented at TU Dresden in November 2018.
Angiotensin converting enzyme intron 16 insertion/deletion genotype is associated with plasma C-reactive protein concentration in uteroplacental dysfunction
Creators: name: Häupl, Thomas
name: Zimmermann, Mathias
name: Kalus, Ulrich
name: Yürek, Salih
name: Koscielny, Jürgen
name: Hoppe, Berthold
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: Angiotensin-converting enzyme
subject: C-reactive protein
subject: uteroplacental circulation
subject: inflammation
subject: genotype
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Introduction: Disturbance of the uteroplacental circulation (UPC) and the renin-angiotensin system are involved in the pathogenesis of preeclampsia. In women with history of preeclampsia persistently elevated C-reactive protein (CRP) levels have been described. The angiotensin-converting enzyme (ACE) intron 16 insertion/deletion (I/D) genotype is associated with ACE activity and assumed to be a risk factor for preeclampsia. As ACE generates proinflammatory angiotensin II, we analysed, whether ACE intron 16 I/D genotype is associated with CRP and whether this association exhibited a relation to uteroplacental dysfunction. Materials and methods: A total of 639 women have been followed during pregnancy with repeated measurements of CRP levels (observations: n=2333). ACE intron 16 I/D genotype was determined, and its association with CRP was assessed with adjustment for non-independent observations. Results: CRP levels of ACE D allele carriers were significantly higher than those of the ACE II (wild-type) genotype (p=0.0003, p adj=0.04). This relation was allele-dose dependent (p<10−4, p adj<0.02). Association between ACE I/D and CRP was significantly restricted to patients presenting with impaired UPC in univariate (p<0.04) and multivariate analyses (p=0.01). Conclusions: The ACE I/D genotype is significantly associated with CRP elevations during pregnancies complicated by disturbed UPC. Whether this effect on CRP is involved in pathogenesis of preeclampsia has to be elucidated.
Resolving structure of the disc around HD100546 at 7 mm with ATCA
Creators: name: Wright, C. M.
name: Maddison, Sarah
name: Wilner, D. J.
name: Burton, M. G.
name: Lommen, D.
name: van Dishoeck, E. F.
name: Pinilla, P.
name: Bourke, T. L.
name: Menard, F.
name: Walsh, C.
Publisher: name: Swinburne
Year: 2024

description: There is much evidence that planet formation is occurring in the disk around the Herbig Be star HD100546. To learn more about the processes occurring in this disk we conducted high resolution imaging at 43/45 GHz with the Australia Telescope Compact Array (ATCA). Multiple array configurations were used, providing a best spatial resolution of ∼ 0.15 arcsec, or 15 AU at HD100546's distance of ∼ 100 pc. Significant structure is revealed, but its precise form is dependent on the u−v plane sampling used for the image reconstruction. At a resolution of ≤ 30 AU we detected an inner gap in the disk with a radius of ∼ 25 AU and a position angle approximately along the known disk major axis. With different weighting, and an achieved resolution of ∼ 15 AU, emission appears at the centre and the disk takes on the shape of an incomplete ring, much like a horseshoe, again with a gap radius of ∼ 25 AU. The position angle of the disk major axis and its inclination from face-on are determined to be 140∘±5∘ and 40∘±5∘ respectively. The ∼ 25 AU gap radius is confirmed by a null in the real part of the binned visibilities at 320±10 kλ, whilst the non-axisymmetric nature is also confirmed through significant structure in the imaginary component. The emission mechanism at the central peak is most likely to be free-free emission from a stellar or disk wind. Overall our data support the picture of at least one, but probably several, giant planets orbiting HD100546 within 25 AU.
Tracking down old relatives: Zero relatives in subject and non-subject function in early African American English.
Creators: name: Harvie, Dawn Marie.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Language, Linguistics.

description: Relativization has been overlooked in the African American Vernacular English (AAVE) origins debate, perhaps because its variants are neither particularly stigmatized nor associated with AAVE. This thesis, a contribution to the origins debate and the understanding of relativization in English, examines relativization in Early African American English (AAE) by extending an analysis of the Ex-Slave Recordings to African Nova Scotian English and Samana English. Examination of syntactic, grammatical, discourse-contextual and semantic factors demonstrates interaction between factors and the necessity of separating subject and non-subject relatives. Nevertheless, these varieties of Early AAE appear to share a common relativization system. The sparse, contradictory evidence on relativization in AAVE and creoles precludes strong conclusions about their relation to Early AAE, but its similarities to other English varieties support an English, not creole, origin and parallel accumulating evidence for its resemblance to colonial white varieties with which it was in contact.
title: Rechtsfragen im Kontext einer Lieferkettenregulierung
title: Rechtsfragen im Kontext einer Lieferkettenregulierung
titleType: AlternativeTitle
Creators: name: Gailhofer, Peter
Publisher: name: Umweltbundesamt
Year: 2020
Subjects: subject: Rechtsfragen
subject: Lieferkettenregulierung
subject: umweltbezogene Sorgfaltspflichten
subject: Wirtschaft | Konsum
subject: Nachhaltigkeit | Strategien | Internationales

description: Die rechtliche Verankerung umweltbezogener und menschenrechtlicher Sorgfaltspflichten ist ein Ansatz zur Stärkung einer nachhaltigen Unternehmensführung in globalen Wertschöpfungsketten. Dieser Ansatz ist in den letzten Jahren zunehmend Gegenstand wissenschaftlicher Arbeiten geworden. Politische und schließlich gesetzgeberische Initiativen zur Schaffung eines Lieferkettengesetzes folgten. Das vorliegende rechtswissenschaftliche Autorenpapier soll einen Beitrag zur aktuellen Diskussion leisten. Der Papier adressiert zahlreiche Bedenken und entwickelt ein differenziertes Verständnis umweltbezogener Sorgfaltspflichten. Es wird deutlich, dass ein Gesetz im Sinne der gerade diskutierten Entwürfe schon heute ein gut austariertes Gefüge unterschiedlicher Pflichten schaffen kann, die - in Kombination mit unterschiedlichen Durchsetzungsmechanismen - eine faire, praktikable und effektive Regulierung der Lieferkette sicherstellen. Quelle: https://www.umweltbundesamt.de/
description: Die rechtliche Verankerung umweltbezogener und menschenrechtlicher Sorgfaltspflichten ist ein Ansatz zur Stärkung einer nachhaltigen Unternehmensführung in globalen Wertschöpfungsketten. Dieser Ansatz ist in den letzten Jahren zunehmend Gegenstand wissenschaftlicher Arbeiten geworden. Politische und schließlich gesetzgeberische  Initiativen zur Schaffung eines Lieferkettengesetzes folgten. Das vorliegende rechtswissenschaftliche Autorenpapier soll einen Beitrag zur aktuellen Diskussion leisten.Der Papier adressiert zahlreiche Bedenken und entwickelt ein differenziertes Verständnis umweltbezogener Sorgfaltspflichten. Es wird deutlich, dass ein Gesetz im Sinne der gerade diskutierten Entwürfe schon heute ein gut austariertes Gefüge unterschiedlicher Pflichten schaffen kann, die – in Kombination mit unterschiedlichen Durchsetzungsmechanismen – eine faire, praktikable und effektive Regulierung der Lieferkette sicherstellen.
Governing the e-subject through identity theft discourses
Creators: name: Klockars, Karl
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: subject: Sociology, Criminology and Penology.

description: This study explores the social construction of identity theft, including its meanings, risk factors, specific causes and accompanying solutions, articulated in policy documents published by the Consumer Measures Committee (a sub-committee of Industry Canada) and the Royal Bank of Canada. A qualitative analysis of the documents indicates that identity theft is predominately constructed within the documents as an individualized consumer concern. This is in keeping with the shift to neoliberalism identified by Monahan (2009) and Caeton (2007). Within this, individuals are constructed as buying into the electronic marketplace, aligning their own motivations with larger political and economic objectives, while trusting in the advice of experts to overcome manageable risks.
title: Comparison of methods for the estimation of total inorganic nitrogen deposition to forests in Germany
title: Comparison of methods for the estimation of total inorganic nitrogen deposition to forests in Germany
titleType: AlternativeTitle
Creators: name: Ahrends, Bernd
name: Geupel, Markus
name: Schmitz, Andreas
name: Prescher, Anne-Katrin
Publisher: name: My University
Year: 2020
Subjects: Stickstoff
Wald
Ablagerung
Bundesrepublik Deutschland

description: A reliable quantification of total inorganic nitrogen (TIN) deposition to forests is required for the evaluation of ecological effects of TIN inputs to forests and to monitor the success of clean-air policy. As direct measurements are scarce, different modeling approaches have been developed to estimate TIN deposition to forests. Three common methods are the (i) "canopy budget model," (ii) "inferential method," and (iii) "emission based estimates" using a chemical transport model. Previous studies have reported considerable and site-specific differences between these methods, complicating the interpretation of results. We use data from more than 100 German intensive forest monitoring sites over a period of 16 years for a cross-comparison of these approaches. Non-linear mixed-effect models were applied to evaluate how factors like meteorology, terrain and stand characteristics affect discrepancies between the model approaches. Taking into account the uncertainties in deposition estimates, there is a good agreement between the canopy budget and the inferential method when using semi-empirical correction factors for deposition velocity. Wet deposition estimates of the emission based approach were in good agreement with wet-only corrected bulk open field deposition measurements used by the other two approaches. High precipitation amounts partly explained remaining differences in wet deposition. Larger discrepancies were observed when dry deposition estimates are compared between the emissions based approach and the other two approaches, which appear to be related to a combination of meteorological conditions and tree species effects. © 2020 Ahrends, Schmitz, Prescher, Wehberg, Geupel, Andreae and Meesenburg
Schwerpunkte 2017 - Jahrespublikation des Umweltbundesamtes
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2017
Subjects: subject: Umweltbundesamt
subject: Landwirtschaft
subject: Innenraumluft
subject: Klimaschutz
subject: Schwerpunkte
subject: Jahresbericht
subject: Das UBA
subject: Klima | Energie
subject: Luft
subject: Landwirtschaft
subject: Gesundheit

description: Die Landwirtschaft in ihrer heutigen Form ist für die Umwelt oft eine echte Belastungsprobe. / Wie gut die Luft in unseren Innenräumen ist, bestimmen wir großteils selbst. / Was das Klimaübereinkommen von Paris für Deutschland bedeutet.Ein Heft, drei Themen - die Jahrespublikation des Umweltbundesamtes vertieft aktuelle Umweltfragen aus wissenschaftlicher Sicht. Weitere Themen sind das ⁠UBA⁠ als Arbeitgeber und ob mit Kunst der Wandel im Umwelt- und Klimabewusstsein zu schaffen ist.
Assessment of biomethane potential and reactor foaming during anaerobic co-digestion of organics
Creators: name: Garrett, Alexes S.
Publisher: name: University of Iowa
Year: 2022
Subjects: anaerobic digestion
biomethane
biomethane potential
co-digestion
digester foaming
high strength wastes
public abstract

description: Process stability is an ongoing difficulty in anaerobic digestion due to the interdependent biochemical processes that convert organic wastes to methane-rich biogas. In this study we investigated excessive foaming at a rural Water Resource Recovery Facility that co-digests mixed high strength organic wastes (HSW) (COD > 100,000 mg/L). Circumstances required a disproportionate use of HSW feedstock in 2020, which triggered excessive foaming and digester overflowing (“foam-over”). Limited data on the HSW and its impacts on the digester conditions made targeted mitigation difficult. To assist, we developed a predictive model of the facility’s dual mesophilic digesters. Composition and operational data were used to calibrate the model to investigate the underlying triggers for the foaming. Our analysis suggested that the foam-over events were caused by synergetic interactions between VS loading above 0.15 lb-VS/ft3/day, enhanced biogas generation from high (≥ 50%) HSW contributions, and low residence times. We then conducted a series of biomethane potential tests on the HSW to investigate potential toxicity. The HSW did not exhibit toxicity but instead bolstered biogas production and enhanced digester nutrient content. Since the HSW is frequently used as the predominant feedstock, understanding how the interactions between the HSW, foaming, and the overall digester condition could enable targeted strategies for improving process stability.
title: Racial-ethnic disparities along the continuum of breast cancer care
title: treatment quality and survival
titleType: Subtitle
Creators: name: Herbach, Emma
Publisher: name: University of Iowa
Year: 2022
Subjects: breast
cancer
disparities
ethnicity
race
racism
public abstract

description: Background. Despite lower incidence of breast cancer among Black and American Indian/Alaska Native (AIAN) women, Black and AIAN women are more likely to die from the disease than non-Hispanic Whites (NHW). Differences in treatment quality contribute to these survival disparities. The purpose of this dissertation was to characterize racial-ethnic differences in quality along the continuum of breast cancer care from diagnosis through end of life.
description: Methods. We performed three studies using the Surveillance, Epidemiology, and End Results (SEER) Program data linked with Medicare Fee-For-Service (FFS) insurance claims. In the first study, we described patterns of care by race-ethnicity in terms of the individual evidence-based services recommended by clinical practice guidelines and established quality metrics. In the second study, we examined racial-ethnic disparities in guideline-concordance in the context of where patients seek care and where they live using multilevel modeling. In the final study, we explored the role of guideline-recommended care in racial-ethnic differences in survival at one- and five-years from breast cancer diagnosis.
description: Results. Black and AIAN women were consistently less likely to receive the standard of breast cancer care compared to NHW from diagnosis through first-line treatment. Patients treated at better resourced facilities were more likely to receive guideline-recommended care, while residence in medically underserved areas (e.g., racially segregated) was associated with lower quality care. Black and AIAN women had increased risk of death at one- and five-years after their breast cancer diagnosis. However, survival disparities were more affected by baseline comorbidity and frailty than by differences in treatment quality.
description: Conclusions. Racial-ethnic disparities in quality of care begin early in the clinical course; efforts to equitably deliver high-quality treatment must include equitable delivery of recommended diagnostics and clinical workup procedures. However, improving access to high-quality care without simultaneously addressing the social and structural root causes of disparities in health, healthcare, and patient outcomes may not ameliorate racial-ethnic survival disparities.
Critical Load Daten für die Berichterstattung 2015-2017 im Rahmen der Zusammenarbeit unter der Genfer Luftreinhaltekonvention (CLRTAP)
Creators: name: Schlutow, Angela
name: Nagel, Hans-Dieter
name: Bouwer, Yolandi
Publisher: name: My University
Year: 2018
Subjects: subject: Critical Load
subject: Versauerung
subject: Eutrophierung
subject: Biologische Vielfalt
subject: ökologische Belastbarkeitsgrenzen
subject: Biodiversität
subject: BERN-Modell
subject: Exceedance
subject: Luft

description: Im Rahmen der Berichtspflichten Deutschlands für die Konvention über weitreichende grenzüberschreitende Luftverunreinigungen wurde ein neuer deutscher Datensatz zu den ökosystemspezifischen Belastungsgrenzen (Critical Load) für das europäische Koordinierungszentrum bereitgestellt. Die Berechnung der Critical Load für versauernde Schwefel- und Stickstoffeinträge sowie für die eutrophierende Stickstoffbelastung erfolgte entsprechend des 2017 aktualisierten Mapping Manual nach der Massenbilanzmethode. Darüber hinaus wurden zusätzlich auch Critical Load mit dem Schutzziel ⁠Biodiversität⁠ bestimmt.
The meaning of social support: The perspective of Arab Canadians with congestive heart failure.
Creators: name: Debs-Ivall, Salma.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Health Sciences, Nursing.

description: The incidence of congestive heart failure (CHF) rises annually and, despite advances in medical treatments, the prognosis remains poor. Since CHF has no cure, the treatment is mostly supportive symptom management and prevention of exacerbation. Studies examining the impact of social support on CHF have found that social support helps to prevent hospitalization and helps patients with CHF adhere to the prescribed medication and lifestyle changes. The purpose of this study was to explore the meaning of social support to Arab Canadians with CHF. The Arab immigrant population is at risk of many health problems because of traumas associated with the immigration experience and limited knowledge of a complex health care system. The qualitative method of particularistic ethnography was used to gain a better understanding of the meaning of support in this cultural group. In depth, semi-structured, audio-taped interviews were conducted with a sample of 7 Lebanese Christian participants. The data analysis revealed 3 themes: "My family will take care of me"; "I rely on God"; and The illness is not important. Nursing implications and recommendations have been proposed to address the needs of this cultural group.
title: Asymptomatic only at first sight
title: malaria infection among schoolchildren in highland Rwanda
titleType: Subtitle
Creators: name: Sifft, Kevin C.
name: Geus, Dominik
name: Mukampunga, Caritas
name: Mugisha, Jean Claude
name: Habarugira, Felix
name: Fraundorfer, Kira
name: Bayingana, Claude
name: Ndoli, Jules
name: Umulisa, Irenee
name: Karema, Corine
name: Von Samson-Himmelstjerna, George
name: Aebischer, Toni
name: Martus, Peter
name: Sendegeya, Augustin
name: Gahutu, Jean Bosco
name: Mockenhaupt, Frank P.
Publisher: name: Freie Universität Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft

description: Background Plasmodium infection and malaria in school children are increasingly recognized as a relevant public health problem, but data on actual prevalence and health consequences are insufficient. The present study from highland southern Rwanda aimed at estimating infection prevalence among children attending school, at identifying associated factors and at assessing the clinical consequences of these infections. Methods In a survey including 12 schools in the Huye district of Rwanda, 1089 children aged 6–10 years were clinically and anthropometrically examined, malaria parasites were diagnosed by microscopy and PCR, haemoglobin concentrations were measured, and socio- economic and behavioural parameters as well as medical histories were obtained. Results Upon examination, the vast majority of children was asymptomatic (fever 2.7%). Plasmodium infection was detected in 22.4% (Plasmodium falciparum, 18.8%); 41% of these were submicroscopic. Independent predictors of infection included low altitude, higher age, preceding antimalarial treatment, and absence of electricity or a bicycle in the household. Plasmodium infection was associated with anaemia (mean haemoglobin difference of −1.2 g/dL; 95% CI, −0.8 to −1.5 g/dL), fever, underweight, clinically assessed malnutrition and histories of fever, tiredness, weakness, poor appetite, abdominal pain, and vomiting. With the exception of underweight, these conditions were also increased at submicroscopic infection. Conclusion Malaria infection is frequent among children attending school in southern highland Rwanda. Although seemingly asymptomatic in the vast majority of cases, infection is associated with a number of non-specific symptoms in the children´s histories, in addition to the impact on anaemia. This argues for improved malaria surveillance and control activities among school children.