cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Analysis of the Ran pathway in mitosis using a novel small molecule inhibitor
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: During the cell-division cycle cells accurately duplicate themselves and then divide into two daughter cells. Proper regulation of the events of the cell cycle is essential for successful division and the prevention of uncontrolled cell proliferation and tumorigenesis. The mitotic spindle has the essential function of correctly distributing the duplicated chromosomes prior to the onset of cytokinesis. Mitotic spindle assembly is a highly regulated and complex process that requires the function of multiple pathways. Recently, the small GTPase Ran has been identified as a key factor involved in chromatin-mediated events during spindle assembly. Ran regulates interactions between nuclear transport receptors of the importin ß family and cargoes. Several of these importin ß cargoes were shown to function during spindle assembly in Xenopus egg extracts including the tumor suppressor BRCA1. In addition, Ran and importin ß seem to regulate several proteins that were previously shown to be misregulated in cancer cells including the Aurora A kinase and the hepatoma-upregulated protein HURP. However, the role of the RanGTP-importin ß pathway during mitosis in somatic cells or in cancer cells remains unclear. We have identified a novel small molecule inhibitor of the RanGTP-importin ß interaction, termed JFS110303. The goal of this grant is to use this new compound to characterize the function of the RanGTP-importin ß pathway in mitotic spindle assembly in living cells. We propose two specific aims: (1) We will biochemically characterize JFS110303 in order to understand how the compound disrupts the RanGTP-importin ß interaction. (2) We will use the compound to inhibit the Ran-importin ß pathway in living mitotic cells and monitor the effects using a variety of approaches including immunofluorescence and time-lapse video microscopy in various cell lines, both normal and cancerous. These studies will not only help us to better understand the mechanism of mitotic spindle assembly within cells but they should also shed light on the contribution of the Ranregulated spindle assembly pathway to tumorigenesis.
Razianus xinjianganus Lourenco, Sun & Zhu 2010
Creators: name: Tang, Victoria
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Scorpiones
Buthidae
Razianus
Razianus xinjianganus

description: (1) Razianus xinjianganus Lourenço, Sun & Zhu, 2010 TYPE LOCALITY AND TYPE DEPOSITORY. China, Xinjiang Uyghur Autonomous Region, Kashgar Prefecture, near Tajikistan; MHBU (lost).
CHINESE EQUIVALENT. Dzḋn'兹x.
DISTRIBUTION (●). Xinjiang: Kashgar Prefecture.
description: Published as part of Tang, Victoria, 2025, A review of scorpiofauna of China: nomenclatural notes and updated faunistic catalogue (Arachnida: Scorpiones), pp. 1-24 in Euscorpius 404 on page 15, DOI: 10.5281/zenodo.14660932
LEF-1 translation in chronic myelogenous leukemia
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: We propose to examine alternative translation pathways in Chronic Myelogenous Leukemia (CML) with a specific focus on Lymphoid Enhancer Factor-1 (LEF-1). LEF-1 is a transcription factor that mediates Wnt signaling and is essential in CD34+ hematopoietic cells, the progenitor cells that are transformed in CML. Knockdown of LEF-1 in CML cells causes apoptosis; thus, the pathways that control LEF-1 expression play an important part in the survival of CML cancer cells. Others have observed increases in LEF-1 expression and Wnt signaling in the transition from slow growing chronic phase CML to the deadly and final blast crisis phase; it is possible that LEF-1 participates in this progression. We have discovered that LEF-1 is produced by an alternative protein translation pathway, directed by two internal ribosome entry sites (IRESes). IRESes recruit ribosomes to open reading frames without the need for a m7G-cap on the 5’ end of the mRNA. The mechanism by which this happens is unknown, but we observe that LEF-1 IRESes are upregulated by BcrAbl - the causative oncogene for CML. Inhibition of BcrAbl with the drug Imatinib (Gleevec) destroys LEF-1 protein expression in CML cells and inhibits LEF-1 IRES activity. BcrAbl stimulates general cap-dependent translation of proteins via activation of mTORC1, a cytoplasmic kinase complex that modulates recognition of capped mRNAs. However we find that Rapamycin, a drug that inhibits mTORC1 and cap-dependent translation more directly, does not have much of an affect on LEF-1. This suggests that BcrAbl controls LEF-1 translation through an mTORC1-independent mechanism. The goal of this application is to further narrow the step(s) by which BcrAbl affects LEF-1 protein levels. Specific Aim #1 will address three hypotheses: A) that BcrAbl regulates LEF-1 protein stability, B) that BcrAbl regulates LEF-1 IRES activity through an mTORC-1 independent mechanism and, C) that BcrAbl regulation requires loading of nuclear proteins onto LEF1 mRNA. Specific Aim #2 will develop an in vivo system that allows localization of LEF1 mRNA in cells and rapid isolation of it as an RNA/protein complex. LEF1 mRNAs will be tagged with bacteriophage stem loops for recognition by their cognate RNA binding protein (MS2) fusion to GFP or affinity tags. Results from Specific Aim#1 can be validated with this RNA, but ultimately this system will be used for identifying proteins that bind to LEF1 IRESes and defining the mechanisms by which they respond to BcrAbl action.
Bagre filamentosus
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Siluriformes
Ariidae
Bagre
Bagre filamentosus

description: Bagre filamentosus (Swainson 1839). Filament Sea Catfish; Bagre, Bagre Cacumo, Chulín, Tunki
Vouchers: (other collections) ANSP 25799 (1) and ANSP 25800 (1). Distribution: Western Atlantic Ocean; from Yucatan, Mexico, to central Brazil; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) WK, Pr, GM, KP, Es, BF, IM, To, SJ and LN (Atlantic); 0–11 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; NE, population trend unknown. Literature: Fowler (1923:24; brief description, including information on distribution), Villa (1982: 115; detailed description, including illustrations and an identification key, and information on distribution and ecology), González-Alemán (2006: 21, as Bagre marinus (Mitchill 1815)—misidentification; brief description, including an illustration, and information on distribution and ecology), van den Berghe (2015: 40, as B. marinus —misidentification; listed, including an illustration and information on distribution and ecology), Robertson & Van Tassell (2019: 2970, as B. marinus, in part—misidentification; detailed description, including illustrations, and information on distribution, with a map, and ecology) and Marceniuk et al. (2022: 8; redescription, including information on distribution, with a map, and ecology).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 28, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Tetramorium sericeiventre Emery
Creators: name: Bolton, B.
Publisher: name: Zenodo
Year: 1979
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium sericeiventre

description: Tetramorium sericeiventre Emery
(Figs 34, 35)
Tetramorium sericeiventre Emery, 1877: 370. Syntype worker, Ethiopia: Sciotel (Beccari) (MHN, Geneva) [examined]. Tetramorium blochmanii Forel, 1887: 384. Syntype workers, Madagascar: nr Tamatave, Bois de lÂ´Ivondro (C. Keller) (MHN, Geneva) [examined]. Syn. n.
Worker. Very close to the above but more strongly sculptured. The dorsal surfaces of the head and alitrunk with conspicuous longitudinal rugae, the spaces between which are filled with a dense reticulatepuncturation and are matt and dull. The first gastral tergite is usually completely sculptured, matt and dull, but in a few the sculpture is distinctly stronger on the basal half of the tergite than on the apical.
T. sericeiventre is perhaps the commonest member of its genus in Africa in arid or semi-desert conditions or in any locality where the soil is insolated, sandy and well drained. It occurs from the Mediterranean littoral to the Cape and from the western to the eastern coasts. In the Malagasy region it is decidedly less common and appears to take second place to quadrispinosum.
description: Published as part of Bolton, B., 1979, The ant tribe Tetramoriini (Hymenoptera: Formicidae). The genus Tetramorium Mayr in the Malagasy region and in the New World., pp. 129-181 in Bulletin of the British Museum (Natural History) Entomology 38 on pages 129-181
Reddyanus hainanensis
Creators: name: Tang, Victoria
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Scorpiones
Buthidae
Reddyanus
Reddyanus hainanensis

description: (1) Reddyanus hainanensis (Lourenço, Qi & Zhu, 2005) TYPE LOCALITY AND TYPE DEPOSITORY. China, Hainan Island, southeast region; MNHN.
PROTONYM. Isometrus (Reddyanus) hainanensis Lourenço, Qi & Zhu, 2005.
CHINESE EQUIVALENT. 海øå氏x.
DISTRIBUTION (●). Hainan (“southeast region”).
description: Published as part of Tang, Victoria, 2025, A review of scorpiofauna of China: nomenclatural notes and updated faunistic catalogue (Arachnida: Scorpiones), pp. 1-24 in Euscorpius 404 on page 15, DOI: 10.5281/zenodo.14660932
An Experimental Approach to Debuccalization and Supplementary Gestures
Creators: name: O'Brien, Jeremy
Publisher: name: No Publisher Supplied
Year: 2012

description: Debuccalization is a weakening phenomenon whereby various consonants reduce to laryngeals. Examples include Spanish s-aspiration (s -> h word-finally) and English t-glottalization (t -> ? glottal stop syllable-finally). Previous analyses of debuccalization view it as a lenition process that deletes or manipulates formal phonological features. This dissertation frames debuccalization based on the articulatory gestures involved rather than features. In the default case, debuccalization processes delete oral gestures and leave behind laryngeal gestures. This is captured in an Optimality Theoretic grammar by the low ranking of faithfulness to oral gestures, and the high ranking of faithfulness to laryngeal gestures. The motivation for changing the consonant is a markedness constraint which favors more articulatorily efficient consonants. When this constraint outranks oral faithfulness, consonants debuccalize.This constraint system allows us to account for many cases of debuccalization well, but it highlights other cases where the laryngeal gestures of the debuccalized consonant and the fortis version are not identical--cases which show supplementary gestures. These supplementary gestures require an explanation, and three competing analyses are considered: perceptual faithfulness, dissimilation, and neutralization avoidance. The perceptual faithfulness analysis claims that the laryngeal gesture is changed to make the resulting sound more similar to the underlying sound. The dissimilation analysis states that the laryngeal gesture is changed to make it less like its neighboring sounds. Finally, the neutralization avoidance analysis claims that laryngeal gestures must change to avoid neutralization with other phonemes.I first demonstrate that all three analyses are able to account for the case study of Indonesian k-debuccalization (k -> ? glottal stop in coda position). Moreover, all three are consistent with the principles of Optimality Theory and have plausible motivations. As such, experimental data is used to provide evidence for or against the competing analyses. A perceptual experiment was designed to verify the perceptual faithfulness and dissimilation analyses, evaluating the predictions each analysis makes regarding perceptual similarity. Some evidence is found for the perceptual faithfulness account of Indonesian. An artificial grammar learning experiment was also performed, which was used to test the possibility of a learning bias of avoiding neutralization in phoneme inventories, and the evidence from this experiment provides support for the neutralization avoidance analysis.
Additional file 2: of Enhancing Mental and Physical Health of Women through Engagement and Retention (EMPOWER): a protocol for a program of research
Creators: name: Hamilton, Alison
name: Farmer, Melissa
name: Tannaz Moin
name: Finley, Erin
name: Lang, Ariel
name: Oishi, Sabine
name: Huynh, Alexis
name: Zuchowski, Jessica
name: Haskell, Sally
name: Bevanne Bean-Mayberry
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Individual project description: Facilitating Cardiovascular Risk Screening and Risk Reduction in Women Veterans (Bevanne Bean-Mayberry (PI) and Melissa Farmer (Co-PI)). (DOCX 61Â kb)
Inflammatory reporters of tumorigenesis: Macrophage integrins
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Macrophages are recruited from surrounding tissue into tumors and make up a large portion of the tumor mass. In fact, chronic inflammation involving macrophages correlates with increased probability of tumor metastasis and a poor prognosis for cancer survival. Chronic inflammation is itself a harbinger of certain cancers, for instance development of cancer in the stomach is related to infection with heliobacter pylori, and lung cancer is casually related to cigarette smoke and asbestos. In all cases of chronic inflammation the persistent recruitment of monocyte derived macrophages establishes a microenvironment in which the extracellular matrix is broken down and enriched in growth factors and cytokines released by these cells. Tumors exploit the matrix remodeling capacities of macrophages and also may interact and signal them to enhance these secretory and mutagenic processes. Although there are many studies that have shown a correlation between the presence and effects of macrophages in tumor malignancy and invasiveness, very few have focused on the adhesion molecules and signaling mechanisms associated with tumor recognition by macrophages. Our primary hypothesis is this molecular assembly serves to coordinate subsequent macrophage response in terms of migratory activity, matrix remodeling, and synthesis of cytokines. A systems bioengineering approach will be applied to produce a microfluidics based chamber to examine the importance of adhesion receptor ligation and tumor recognition at the cell and molecular scale as described in two Specific Aims: 1) To image interactions between different tumor cell lines, macrophages, and endothelium in a custom vascular mimetic flow channel system with the goal of assessing recruitment and migration of monocytes on vascular endothelium adjacent to proliferating tumor cells. 2) Detect the repertoir of integrins and Ig Superfamily counter-receptors associated with tumor cell recognition and subsequent activation of the monocyte/macrophage. Our overall goal is to detect integrin activation on macrophages that are associated with high affinity binding to ICAMs and VCAMs on tumor cells. Imaging with fluorescent peptides and antibodies to neo-epitopes is expected to provide a valuable bio-reporter for early stages in tumorigenesis.
Results from the joint IRENA and IEECP workshop: Stakeholder-driven scenarios for a just transition to climate neutrality
Creators: name: Süsser, Diana
Publisher: name: Zenodo
Year: 2024

description: SSH CENTRE (Social Sciences and Humanities for Climate, Energy aNd Transport Research Excellence) is a Horizon Europe project, engaging directly with stakeholders across research, policy, and business (including citizens) to strengthen social innovation, SSH-STEM collaboration, transdisciplinary policy advice, inclusive engagement, and SSH communities across Europe, accelerating the EU’s transition to carbon neutrality. SSH CENTRE is based in a range of activities related to Open Science, inclusivity and diversity – especially with regards Southern and Eastern Europe and different career stages –  including: development of novel SSH-STEM collaborations to facilitate the delivery of the EU Green Deal; SSH knowledge brokerage to support regions in transition; and the effective design of strategies for citizen engagement in EU R&I activities. Outputs include action-led agendas and building stakeholder synergies through regular Policy Insight events.This is captured in a high-profile virtual SSH CENTRE generating and sharing best practice for SSH policy advice, overcoming fragmentation to accelerate the EU’s journey to a sustainable future.The documents uploaded here are part of WP2 whereby novel, interdisciplinary teams were provided funding to undertake activities to develop a policy recommendation related to EU Green Deal policy. Each of these policy recommendations, and the activities that inform them, will be written-up as a chapter in an edited book collection. Three books will make up this edited collection - one on climate, one on energy and one on mobility. On the 22 November 2023, the International Energy Agency (IRENA) and the Institute for European Energy and Climate Policy (IEECP) organised a hybrid workshop on stakeholder-driven energy scenarios for a just transition. It brought together the scientific community, modellers in governmental institutions, and other energy and climate actors to discuss the importance of developing more partcipatory scenarios for a more inclusive and just transition, as well as the possibilities of involving the wider and interdisciplinary scientific community in national energy scenario planning. The wokshop summary present the results of the offline and online interactions.
Didymoglossum lorencei (Tardieu) Ebihara & Dubuisson
Creators: name: Ahamada H. Saïd
name: Sabine Hennequin
name: Germinal Rouhan
name: Jean-Yves Dubuisson
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Didymoglossum
Didymoglossum lorencei

description: Didymoglossum lorencei (Tardieu) Ebihara & Dubuisson
Didymoglossum lorencei (Tardieu) Ebihara & Dubuisson in Ebihara et al., Blumea 51: 236 (2006). –
Trichomanes lorencei Tardieu, Adansonia, sér. 2, 17 (2): 147, pl. 1, t. 7–13 (1977). – Type: Mauritius, D.H. Lorence 1175 (holo-: P00477828!).
Short description
Epiphytic or lithophytic; long-creeping filiform rhizomes, rootless and densely covered by dense black trichomes, bearing widely separated pending fronds; fronds sessile to subsessile, up to 1.5 cm long, oblong to obovate, entire with entire to undulate margins, with palmate venation and false veins parallel to true veins, hairy with dark not pedunculated trichomes on lamina margins; one single terminal sorus per fertile frond, cylindrical with lips usually parallel and with brown margins.
Global distribution
Comoros, Madagascar, Mauritius, La Réunion.
Distribution in Comoros
Mayotte, Mohéli.
Additional specimens examined
COMOROS: MAYOTTE, Mont Tchaourembo à 2.5 km au SE de la ville de Ouangani, 13 Nov. 2002, F.Rakotondrainibe et al. 6688 (P00311404). MOHÉLI, Piste entre Miringoni et le Chalet St Antoine, 4 Nov. 2008, G.Rouhan et al. 874 (P00684865).
Note
Didymoglossum lorencei has simple and entire fronds bearing marginal starred hairs and always a single sorus, while the morphologically close D. robinsonii (Hook. ex Baker) Copel. (presented here-after) has fronds often lobed to pinnatifid (see Fig. 2B) and often more than one sorus.
description: Published as part of Ahamada H. Saïd, Sabine Hennequin, Germinal Rouhan & Jean-Yves Dubuisson, 2017, Disentangling the diversity and taxonomy of Hymenophyllaceae (Hymenophyllales, Polypodiidae) in the Comoros, pp. 1-53 in European Journal of Taxonomy 313 on page 15, DOI: 10.5852/ejt.2017.313, http://zenodo.org/record/896401
Role of growth signaling pathways in cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Our laboratory is focused on understanding a class of pediatric genetic syndromes, including Sotos, Beckwith-Wiedemann and Simpson-Golabi-Behmel, in which there is tissue overgrowth. Patients affected with these syndromes have an increased risk of specific cancers, including Wilms tumor, rhabdomyosarcomas, neuroblastomas, and leukemias. In these syndromes, abnormal gene regulation results in uncontrolled tissue growth and cancer predisposition. Recent studies have identified a novel signaling pathway required for the regulation of tissue growth, termed the Hippo signaling pathway. We hypothesize that hyper-activation of growth signaling pathways, such as Hippo, leads to overgrowth and cancer predisposition. We have developed a Drosophila melanogaster model of tissue overgrowth and cancer predisposition. This in vivo model will be used to perform a compound screen to identify small molecules capable of rescuing the lethality from the overgrowth phenotype. A large library of compounds will be screened by feeding larvae and assaying for suppression of tissue overgrowth. Our studies could have therapeutic implications for pediatric solid tumors and may aid in our understanding the genetic basis of human overgrowth syndromes.
Reddyanus assamensis
Creators: name: Tang, Victoria
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Scorpiones
Buthidae
Reddyanus
Reddyanus assamensis

description: (2) Reddyanus assamensis (Oates, 1888)
TYPE LOCALITY AND TYPE DEPOSITORY. India, Assam State, Dhburi District; NHMUK.
PROTONYM. Isometrus assamensis Oates, 1888.
SYNONYM. Isometrus (Reddyanus) tibetanus Lourenço & Zhu, 2008 (●). Syn. n.
CHINESE EQUIVALENT. ḃṽñå氏x.
DISTRIBUTION (○). Guangdong (?): Zhuhai City (Beikou Village). Xizang: Shigatse City (Drongpa County: “region of Chesu”).
description: Published as part of Tang, Victoria, 2025, A review of scorpiofauna of China: nomenclatural notes and updated faunistic catalogue (Arachnida: Scorpiones), pp. 1-24 in Euscorpius 404 on page 16, DOI: 10.5281/zenodo.14660932
Elucidation of molecular mechanisms inactivating the retinoblastoma tumor suppressor protein
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The retinoblastoma protein (Rb) regulates the G1-S transition of the cell cycle by binding and inhibiting the E2F family of transcription factors. Rb is inactivated by phosphorylation, which leads to dissociation of the Rb-E2F complex and activation of genes that induce S phase and cell cycle progression. Accordingly, the Rb pathway has antiproliferative function, and genetic alterations to components of the pathway are often found in human cancer. This proposal seeks to understand the molecular mechanisms underlying phosphorylation induced Rb-inactivation. The general hypothesis is that phosphorylation events at distinct sites in Rb alter specific sets of biochemical interactions that stabilize the Rb-E2F complex. The goal is to understand in molecular detail how interactions are changed and which precise sequences are responsible for these changes. To this end, a number of structural and biophysical techniques will be applied to examine effects in binding affinity upon phosphorylation of particular sites and to attain atomic resolution images of how phosphorylation disrupts or induces biochemical interactions. These studies will provide insight into the mechanism of Rb tumor suppressor inactivation and establish a framework for future development of approaches to rescue Rb function in cells where Rb regulation is impaired.
Bagre panamensis .
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Siluriformes
Ariidae
Bagre
Bagre panamensis

description: Bagre panamensis (Gill 1863). Chihuil Sea-Catfish; Bagre, Bagre Chihuil, Cuminate Chihuil
Vouchers: Not available. Distribution: Eastern Pacific Ocean; from southern California, USA, to northern Peru; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) ER and PN (Pacific); 0–6 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; LC (2010), population trend unknown. Literature: Villa (1982: 116; detailed description, including illustrations and an identification key, and information on distribution and ecology) and Robertson & Allen (2015: 580; detailed description, including illustrations, and information on distribution, with a map, and ecology).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 29, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
title: «NaTech bewegt»: MINT-Unterricht mit BNE- und Digitalitätsfokus am Beispiel der nachhaltigen Stadt
Creators: name: Furrer, Florian
name: Hasselmann, Franziska
name: Maurer, Björn
name: Bürgisser, Alex
name: Hagen, Dominik
Publisher: name: Publikationsserver der Pädagogischen Hochschule Thurgau
Year: 2024

description: «NaTech bewegt» ist ein schulisches Bildungsangebot, das darauf abzielt, den Erwerb naturwissenschaftlicher Kompetenzen mit der Arbeit an zentralen Herausforderungen der Nachhaltigen Entwicklung zu verbinden. Ausgangspunkt ist der Anspruch, dass MINT-Bildung in einer «Kultur der Digitalität» im Sinne Stalders (2016) die Notwendigkeit betont, das Verständnis und die Nutzung von (digitaler) Technologie und Digitalisierung als Ergebnis eines gesellschaftlichen Aushandlungsprozesses zu verstehen, der die Perspektive verschiedener Akteur:innen einbezieht und sich an Prinzipien der Nachhaltigkeit orientiert. Anstatt also technik-deterministischen oder technik-solutionistischen Ideologien zu folgen, setzen sich Schüler:innen der 5. und 6. Klasse mit der Frage auseinander, welchen Beitrag naturwissenschaftliche Kompetenzen und der Einsatz von Technologie zur Nachhaltigen Entwicklung leisten können, wo die Grenzen liegen und wo gegebenenfalls weitere Perspektiven einzubeziehen sind. Das Thema «Nachhaltige Stadt» bietet allen Schüler:innen einen sinnstiftenden Rahmen für Reflexion und Kompetenzerwerb. Sie werden mit einem Modell einer nicht nachhaltigen Stadt konfrontiert und haben den Auftrag, das Modell so umzugestalten, dass es den (aktuellen) Grundgedanken einer Nachhaltigen Entwicklung gerecht wird. Im Beitrag wird das Konzept des Angebots vorgestellt und mit fachdidaktischem Fokus beziehungsweise aus Sicht von BNE in einer Kultur der Digitalität diskutiert.
description: Medien - Bildung - Nachhaltige Entwicklung: Inter- und transdisziplinäre Diskurse, p. 144
Regulation of sphingolipid signaling and biosynthesis by Target Of Rapamycin Complex 2 (TORC2)
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Our long-term goal is to understand the molecular mechanisms by which cell growth is controlled by the rapamycin-sensitive TOR kinases. Recent studies have demonstrated that TOR functions as part of two distinct protein complexes, TORC1 and TORC2. We have recently discovered that inhibition of TORC2 affects dramatically the earliest steps of the sphingolipid pathway, in particular the formation of ceramides. Ceramides, as well as their immediate precursors, the fatty acid long chain bases (LCBs), represent classes of lipids that are increasingly recognized as playing crucial roles in malignant cell growth and tumorogenesis. Thus, both TOR and ceramide biosynthesis represent important areas for cancer investigation and our findings indicate for the first time that they are intimately linked. In the experiments proposed here, we will identify the step(s) in ceramide biosynthesis that is controlled by TORC2 as well as begin to delineate the signaling pathway involved in this regulation. First, we will dentify the specific step(s) of ceramide biosynthesis regulated by TORC2. Our preliminary results suggest that TORC2 regulates a step at or prior to the conversion of Phytospingosine (PHS) to PHS-ceramides. We will therefore examine the synthesis of upstream intermediates, including fatty acid LCBs, to determine whether TORC2 acts directly at the step of ceramide synthase or at a prior step. Second, we will identify signaling components that link TORC2 to ceramide production. In this regard, recent studies have identified a distinct number of downstream effectors of TORC2 that could potentially link the activity of this complex to ceramide biosynthesis. We will determine whether one or more of these candidate proteins conveys a signal from TORC2 to this biosynthetic pathway or whether this represents a novel branch of TORC2-dependent activity. Through these studies, we aim to begin to understand the mechanism by which TOR is linked to the ceramide biosynthetic pathway in yeast, culminating in a foundation for ultimately addressing this question in higher eukaryotes, including human cells. Importantly, this proposal uses CRCC funds for the development of a completely new project for my laboratory that is directly relevant for the study of cancer.
Tetramorium simillimum
Creators: name: Bolton, B.
Publisher: name: Zenodo
Year: 1979
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium simillimum

description: The simillimum -group
For definition of the group see page 169.
Madagascar has five representatives of this successful group of small species, two of which are restricted to the region (anodontion and scytalum) although closely related to the African parentstock of the group. The other three species are shared with the Ethiopian region, one of them being very widespread in eastern and southern Africa (delagoense), whilst the final two, simillimum and caldarium, are both accomplished tramp species with a very wide distribution outside Africa, their place of origin. These two tramp species are discussed under the section dealing with the New World fauna.
description: Published as part of Bolton, B., 1979, The ant tribe Tetramoriini (Hymenoptera: Formicidae). The genus Tetramorium Mayr in the Malagasy region and in the New World., pp. 129-181 in Bulletin of the British Museum (Natural History) Entomology 38 on page 155
Additional file 3: Figure S2. of Analyses of methylomes of upland and lowland switchgrass (Panicum virgatum) ecotypes using MeDIP-seq and BS-seq
Creators: name: Mollee Dworkin
name: Shaojun Xie
name: Saha, Malay
name: Jyothi Thimmapuram
name: Venu Kalavacharla
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Plant Biology

description: Violin plot of length of TE that were associated with DMRs. (PDF 19Â kb)
Didymoglossum Desv. (Desvaux 1827
Creators: name: Ahamada H. Saïd
name: Sabine Hennequin
name: Germinal Rouhan
name: Jean-Yves Dubuisson
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Didymoglossum

description: Notes on genus Didymoglossum in Comoros
Didymoglossum lorencei, D. robinsonii and D. erosum are new for the archipelago. They were never reported, likely due to confusions with morphologically close taxa. We can, however, note here that D. erosum, absent in the archipelago according to Tardieu-Blot (1951) and Roux (2009), would be nevertheless present according to the type of Trichomanes erosum var. laciniatum which would have been collected in Comoros. But this type specimen could not be observed nor studied, and its identification remains questionable. Sterile D. erosum is also indeed easily confused with small sterile D. cuspidatum. The confusion is also easy between D. rotundifolium and small D. erosum specimens with entire laminae. The first species never displays lobed fronds contrary to the second. Didymoglossum lorencei and D. robinsonii are often found growing as epiphyte and mixed and confused with other species of Didymoglossum. Only microscopic observation of marginal hairs allows the distinction. It explains that the occurrence of D. lorencei in La Réunion has been reported only recently, because the species is quite discrete and mostly grows on tree-fern trunks in association with the much more abundant D. cuspidatum (pers. obs.; Grangaud 2010).
description: Published as part of Ahamada H. Saïd, Sabine Hennequin, Germinal Rouhan & Jean-Yves Dubuisson, 2017, Disentangling the diversity and taxonomy of Hymenophyllaceae (Hymenophyllales, Polypodiidae) in the Comoros, pp. 1-53 in European Journal of Taxonomy 313 on page 20, DOI: 10.5852/ejt.2017.313, http://zenodo.org/record/896401
Tetramorium anodontion Bolton, 1979, sp. n.
Creators: name: Bolton, B.
Publisher: name: Zenodo
Year: 1979
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium anodontion

description: Tetramorium anodontion sp. n.
(Figs 22, 23)
Holotype worker. TL 2.6, HL 0.68, HW 0.60, CI 88, SL 0.48, SI 80, PW 042, AL 0.74.
Mandibles appearing dull and finely shagreened. (This appears to be an artifact caused by the presence of a waxy layer on the surface of the mandibular blades. In thoroughly cleaned paratypes the mandibles are shining with scattered pits.) Anterior clypeal margin entire, without notch or impression medially. Frontal carinae strong, convex along their length and surmounted by a narrow rim or flange, tending to peter out occipitally and become indistinguishable from the remaining sculpture. Eyes of moderate size, their maximum diameter 0.15, about 0.25 x HW. With the head in full-face view the sides immediately behind the eyes lacking a projecting stout hair. Outline of alitrunk as in Fig. 23, the metanotal groove very weakly marked. Propodeum absolutely unarmed, without trace of spines or teeth. Metapleural lobes broad and bluntly triangular. Node of petiole in dorsal view broader than long. Dorsum of head strongly sculptured, with numerous fine longitudinal rugulae and the interspaces packed with conspicuous reticulate-puncturation which also covers the scrobal areas. Dorsal alitrunk, petiole and postpetiole finely reticulate-rugulose, all interspaces covered by dense, distinctive reticulate-puncturation. First gastral tergite with faint shagreening basally but otherwise unsculptured. Short, stout, blunt hairs present on all dorsal surfaces of head and body. Colour medium brown, dull.
Paratype workers. TL 2.5 - 3.1, HL 0.62 - 0.76, HW 0.57 - 0.68, CI 88 - 93, SL 0.45 - 0.54, SI 76 - 80, PW 0.40 - 0.47, AL 0.72 - 0.86 (18 measured). Maximum diameter of eye 0.14 - 0.17, about 0.24 - 0.25 x HW. As holotype but in a number of workers the waxy layer on the body has been lost so that in some the gaster appears dull, in others polished. In the clean specimens the shagreening of the first gastral tergite is more conspicuous.
Holotype worker, Madagascar: ' Bekonazy to 5 km S. forest W baobabs (n. of Morondava) 24 Mar. 1969, dry forest. M 214, rot. pod of legum tree, shade' (W. L. Brown) (MCZ, Cambridge). Paratypes. 28 workers with same data as holotype (MCZ, Cambridge; BMNH).
T. anodontion is unique in the Malagasy fauna of Tetramorium as it is the only species yet discovered in which the propodeum is completely unarmed.
description: Published as part of Bolton, B., 1979, The ant tribe Tetramoriini (Hymenoptera: Formicidae). The genus Tetramorium Mayr in the Malagasy region and in the New World., pp. 129-181 in Bulletin of the British Museum (Natural History) Entomology 38 on page 156
Nano-virus electrodes for the sensitive and selective detection of prostate-specific membrane antigen in urine
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Urinalysis is not used for routine cancer surveillance, but it could be: biomarkers for both prostate cancer and bladder cancer are expressed in human urine. In order to make urinalysis for these biomarkers routinely feasible in a clinical setting, these assays must be cheap, convenient, and rapid. We propose here to develop a biosensor resembling a pH meter that will display the concentration of these biomarkers within seconds of exposing the sensor surface to urine. This biosensor consists of engineered virus particles covalently attached to a gold electrode surface. The electrical resistance of this “viruselectrode” increases by 20-50% when covalently attached virus particles recognize and bind molecules from a contacting buffer solution. Detection limits with the first generation device extend to 20 nM at present, a range close to levels necessary to detect a prostate cancer marker (PSMA) in urine. These results, constituting proof-of-concept, were recently published (Analytical Chemistry 78 (2006) 3265.) Within the next year, we believe that a revolutionary improvement in this technology can be achieved by miniaturizing this biosensor. Miniaturization will exploit a new nanofabrication technology that we have recently invented (Nature-Materials 5 (2006) 3264.). Here is the key point: Up until now, we have made an electrical measurement across a 2 nm thick phage layer. It is the increase in resistance of this layer that signals specific binding of PSMA to the immobilized phage particles. In this proposal, using the LPNE technology we have just invented, we will evaluate a biosensor in which nanoscopic gold electrodes are embedded within the phage layer. For this “Nano-Virus Electrode”, the electrical path through the ultra-thin phage layer will now be a millimeter, not 20 nm. The new device architecture will solve two practical problems: 1) The influence of the conductivity of the analyte solution (i.e., urine) is eliminated. Since the conductivity of this solution varies widely from sample to sample, it is a serious source of signal drift. The new biosensor literally removes the bulk liquid phase from the measurement, 2) A significant increase in the sensitivity and limit-of-detection of the biosensor is expected, as a consequence of the increased electrical path through the phage layer.
Anti-CD20 IgE for the therapy of B-cell lymphomas
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Anti-CD20 monoclonal antibody therapy has revolutionized the management of B cell lymphomas. The mouse/human chimeric antibody rituximab (Rituxan®, Biogen-IDEC Pharmaceuticals) binds to the CD20 antigen, a 33-35 kDa transmembrane protein expressed in over 90% of B cell non- Hodgkin’s lymphomas (NHL). Rituximab has achieved single agent response rates of 30-70% in NHL without the toxicities associated with conventional cytotoxic agents. The addition of rituximab to a standard chemotherapy regimen has improved disease-free and overall survival in several common forms of NHL. However, drug resistance to anti-CD20 antibodies eventually occurs in most patients, usually despite the continued expression of CD20 by tumor cells. The present proposal seeks to develop a novel anti-CD20 antibody composed of the variable region of rituximab and the human Fc epsilon constant regions (anti-CD20 IgE). We hypothesize that the anti-CD20 IgE will target the tumor and in so doing activate the innate immune response resulting in an acute inflammation in the tumor microenvironment with subsequent tumor destruction. The presence of dead tumor cells would allow the effective uptake and presentation of tumor antigens by antigen presenting cells (APC) resulting in an efficient priming of the adaptive (cellular and humoral) immune response. It is also expected that that immunocomplexes composed of anti-CD20 IgE and apoptotic cancer cells would be able to target APCs resulting in a highly efficient antigen internalization and presentation with the subsequent immune activation. We propose three specific aims: 1) To construct and express the humanized anti-CD20 IgE; 2) To evaluate the properties of the anti-CD20 IgE in vitro; 3) To evaluate the properties of the anti-CD20 IgE in vivo using a special animal model. In summary, the anti-HER2/neu IgE will be capable of a two-pronged attack against cancer cells, through their direct destruction and through the orchestration of a robust tumor specific immune response directed not only against the targeted antigen, but also against a wide range of other tumor antigens. We anticipate that our studies will have a significant impact in the treatment of lymphomas.
Additional file 2: of Predicting high risk births with contraceptive prevalence and contraceptive method-mix in an ecologic analysis
Creators: name: Perin, Jamie
name: Agbessi Amouzou
name: Neff Walker
Publisher: name: Figshare
Year: 2017
Subjects: subject: Molecular Biology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Marine Biology
subject: Computational Biology

description: Graphics for the predictions in the scenarios as shown for Zambia and Nicaragua for 71 countries are included. (PDF 111Â kb)
Chaerilus conchiformus Zhu, Han & Lourenco 2008
Creators: name: Tang, Victoria
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Scorpiones
Chaerilidae
Chaerilus
Chaerilus conchiformus

description: (2) Chaerilus conchiformus Zhu, Han & Lourenço, 2008 TYPE LOCALITY AND TYPE DEPOSITORY. China, Tibet Autonomous Region, Nyingchi City, Bayi District, Bayi Town; MHBU (lost).
MISIDENTIFICATION. Chaerilus pictus (Pocock, 1890).
CHINESE EQUIVALENT. ffi形ṅfflx.
DISTRIBUTION (●). Xizang: Nyingchi City (Bayi District: Baishuwang and Bayi towns; Mainling City: Zhaxiraodeng Township and Milin Town).
description: Published as part of Tang, Victoria, 2025, A review of scorpiofauna of China: nomenclatural notes and updated faunistic catalogue (Arachnida: Scorpiones), pp. 1-24 in Euscorpius 404 on page 16, DOI: 10.5281/zenodo.14660932
Bagre pinnimaculatus
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Siluriformes
Ariidae
Bagre
Bagre pinnimaculatus

description: Bagre pinnimaculatus (Steindachner 1876). Long-Barbeled Sea-Catfish, Red Sea-Catfish; Bagre, Cuminate, Alguacil, Bagre Barbón, Cuminate Rojo, Cuminate Volador
Vouchers: Not available. Distribution: Eastern Pacific Ocean; from southern Baja California, Mexico, to northern Peru; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) ER and PN (Pacific); 0–6 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; LC (2019), population trend unknown. Literature: Villa (1982: 116; detailed description, including illustrations and an identification key, and information on distribution and ecology) and Robertson & Allen (2015: 578; detailed description, including illustrations, and information on distribution, with a map, and ecology).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 29, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788