cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs
Creators: name: Jimbo, Masaya
name: Yeo, Charles
name: Katz, L. Jay
name: Comstock, Clay E. S.
name: Spaeth, George L.
name: Hark, Lisa
name: Mattick, John S.
name: Rostami, Abdolmohamad
name: Hollingsworth, Michael A.
name: Gomella, Leonard
name: Rigoutsos, Isidore
name: Van Roosbroeck, Katrien
name: Nelson, Peter T.
name: Cozzitorto, Joseph
name: Shaw, Chad A.
name: Delgrosso, Kathleen
name: Witkiewicz, Agnieszka
name: Brody, Jonathan R.
name: Yeh, Jen Jen
name: Zupo, Simona
name: McKenzie, Steven E.
name: Knudsen, Karen E.
name: Fortina, Paolo
name: Calin, George A.
name: Keating, Michael J.
name: Jimenez, Sergio A.
name: Bray, Paul
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: MicroRNAs (miRNAs) are small ∼22-nt RNAs that are important regulators of posttranscriptional gene expression. Since their initial discovery, they have been shown to be involved in many cellular processes, and their misexpression is associated with disease etiology. Currently, nearly 2,800 human miRNAs are annotated in public repositories. A key question in miRNA research is how many miRNAs are harbored by the human genome. To answer this question, we examined 1,323 short RNA sequence samples and identified 3,707 novel miRNAs, many of which are human-specific and tissue-specific. Our findings suggest that the human genome expresses a greater number of miRNAs than has previously been appreciated and that many more miRNA molecules may play key roles in disease etiology.
Risk-Averse Optimization for Resilience Enhancement of Complex Engineering Systems under Uncertainties
Creators: name: Wu, Jiaxin
name: Wang, Pingfeng
Publisher: name: arXiv
Year: 2020
Subjects: subject: Systems and Control (eess.SY)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: With the growth of complexity and extent, large scale interconnected network systems, e.g. transportation networks or infrastructure networks, become more vulnerable towards external disruptions. Hence, managing potential disruptive events during the design, operating, and recovery phase of an engineered system therefore improving the system's resilience is an important yet challenging task. In order to ensure system resilience after the occurrence of failure events, this study proposes a mixed-integer linear programming (MILP) based restoration framework using heterogeneous dispatchable agents. Scenario-based stochastic optimization (SO) technique is adopted to deal with the inherent uncertainties imposed on the recovery process from nature. Moreover, different from conventional SO using deterministic equivalent formulations, additional risk measure is implemented for this study because of the temporal sparsity of the decision making in applications such as the recovery from extreme events. The resulting restoration framework involves a large-scale MILP problem and thus an adequate decomposition technique, i.e. modified Lagrangian dual decomposition, is also employed in order to achieve tractable computational complexity. Case study results based on the IEEE 37-bus test feeder demonstrate the benefits of using the proposed framework for resilience improvement as well as the advantages of adopting SO formulations.
Using 3D Spectroscopy to Probe the Orbital Structure of Composite Bulges
Creators: name: Erwin, Peter
name: Saglia, Roberto
name: Thomas, Jens
name: Fabricius, Maximilian
name: Bender, Ralf
name: Rusli, Stephanie
name: Nowak, Nina
name: Beckman, John E.
name: Beltrán, Juan Carlos Vega
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Detailed imaging and spectroscopic analysis of the centers of nearby S0 and spiral galaxies shows the existence of "composite bulges", where both classical bulges and disky pseudobulges coexist in the same galaxy. As part of a search for supermassive black holes in nearby galaxy nuclei, we obtained VLT-SINFONI observations in adaptive-optics mode of several of these galaxies. Schwarzschild dynamical modeling enables us to disentangle the stellar orbital structure of the different central components, and to distinguish the differing contributions of kinematically hot (classical bulge) and kinematically cool (pseudobulge) components in the same galaxy.
description: LaTeX, 2 pages, 1 PDF figure. To appear in "Proceedings of IAU Symposium 309: Galaxies in 3D across the Universe", eds. B. L. Ziegler, F. Combes, H. Dannerbauer, and M. Verdugo
Base-enhanced catalytic water oxidation by a carboxylate–bipyridine Ru(II) complex
Creators: name: Meyer, Thomas J.
name: Coggins, Michael K.
name: Vannucci, Aaron K.
name: Rudd, Jennifer A.
name: Binstead, Robert A.
name: Song, Na
name: Dares, Christopher J.
name: Concepcion, Javier J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Development of rapid, robust water oxidation catalysts remains an essential element in solar water splitting by artificial photosynthesis. We report here dramatic rate enhancements with added buffer bases for a robust Ru(II) polypyridyl catalyst with a calculated half-time for water oxidation of ∼7 μs in 1.0 M phosphate. The results of detailed kinetic studies provide insight into the water oxidation mechanism and an important role for added buffer bases in accelerating water oxidation by concerted atom–proton transfer.
Zero subsums in vector spaces over finite fields
Creators: name: Pohoata, Cosmin
name: Zakharov, Dmitriy
Publisher: name: arXiv
Year: 2020
Subjects: subject: Combinatorics (math.CO)
subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: The Olson constant $\mathcal{O}L(\mathbb{F}_{p}^{d})$ represents the minimum positive integer $t$ with the property that every subset $A\subset \mathbb{F}_{p}^{d}$ of cardinality $t$ contains a nonempty subset with vanishing sum. The problem of estimating $\mathcal{O}L(\mathbb{F}_{p}^{d})$ is one of the oldest questions in additive combinatorics, with a long and interesting history even for the case $d=1$. In this paper, we prove that for any fixed $d \geq 2$ and $ε> 0$, the Olson constant of $\mathbb{F}_{p}^{d}$ satisfies the inequality $$\mathcal{O}L(\mathbb{F}_{p}^{d}) \leq (d-1+ε)p$$ for all sufficiently large primes $p$. This settles a conjecture of Hoi Nguyen and Van Vu.
Buried ionizable networks are an ancient hallmark of G protein-coupled receptor activation
Creators: name: Dohlman, Henrik G.
name: Isom, Daniel G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: In the early 1980s, scientists began searching for cell-surface receptors that bind to hormones and neurotransmitters. Among the first was the β-adrenergic receptor, a G protein-coupled receptor (GPCR) that is activated by norepinephrine and epinephrine. Recent breakthroughs have provided more than 100 new GPCR structures, including several in activated conformations. This new structural information presents an opportunity to identify features that distinguish unactivated and activated receptors. Here we use a computational approach to identify structural signatures unique to activated GPCRs. Remarkably, we find that these signatures also are present in distantly related receptors from archaea and bacteria. We propose that these new structural indicators are central to GPCR function and are indicative of GPCR activation.
On a theorem of Wiegerinck
Creators: name: Szőke, Róbert
Publisher: name: arXiv
Year: 2020
Subjects: subject: Complex Variables (math.CV)
subject: FOS: Mathematics

description: A theorem of Wiegerinck says that the Bergman space over any domain in $\mathbb C$ is either trivial or infinite dimensional. We generalize this theorem in the following form. Let E be a hermitian, holomorphic vector bundle over $\mathbb P^1$, the later equipped with a volume form and $D$ an arbitrary domain in $\mathbb P^1$. Then the space of holomorphic L2 sections of $E$ over $D$ is either equal to $H^0(M,E)$ or it has infinite dimension.
description: financial support acknowledged
Das Recht von Frauen auf volle Bürgerinnenschaft und auf Entscheidungsbefugnis in der Kirche
Creators: name: Pintos, Margarita M.
Publisher: name: Concilium
Year: 1970

description: Concilium, Bd. 38 Nr. 5 (2002): Concilium: Internationale Zeitschrift für Theologie, Band 38, Heft 5
Transient lateral photovoltaic effect in patterned metal-oxide-semiconductor films
Creators: name: Cascales, J. P.
name: Martinez, I.
name: Diaz, D.
name: Rodrigo, J. A.
name: Aliev, F. G.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optics (physics.optics)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The time dependent transient lateral photovoltaic effect has been studied with us time resolution and with chopping frequencies in the kHz range, in lithographically patterned 21 nm thick, 5, 10 and 20 um wide and 1500 um long Co lines grown over naturally passivated p-type Si (100). We have observed a nearly linear dependence of the transitorial response with the laser spot position. A transitorial response with a sign change in the laser-off stage has been corroborated by numerical simulations. A qualitative explanation suggests a modification of the drift-diffusion model by including the in uence of a local inductance. Our findings indicate that the microstructuring of position sensitive detectors could improve their space-time resolution.
description: 4 pages, 4 figures
Chemical dispersants can suppress the activity of natural oil-degrading microorganisms
Creators: name: Harrison, Sarah
name: Malkin, Sairah Y.
name: Dittmar, Thorsten
name: Sogin, Mitchell L.
name: Kleindienst, Sara
name: Loftis, Kathy
name: Joye, Samantha B.
name: Field, Jennifer
name: Perkins, Matthew J.
name: Passow, Uta
name: Grim, Sharon
name: Seidel, Michael
name: Medeiros, Patricia M.
name: Ziervogel, Kai
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Oil spills are a significant source of hydrocarbon inputs into the ocean. In response to oil spills, chemical dispersants are applied to the oil-contaminated seawater to disperse surface slicks into smaller droplets that are presumed to be more bioavailable to microorganisms. We provide evidence that chemical dispersants applied to either deep water or surface water from the Gulf of Mexico did not stimulate oil biodegradation. Direct measurement of alkane and aromatic hydrocarbon oxidation rates revealed either suppression or no stimulation of oil biodegradation in the presence of dispersants. However, dispersants affected microbial community composition and enriched bacterial populations with the ability to use dispersant-derived compounds as growth substrates, while oil-alone amendments enriched for natural hydrocarbon degraders.
title: Theoretical Analysis and Numerical Investigation of Atrium Fire Engineering Design Principles
Creators: name: Chan, Tsun Bong
Publisher: name: University of Central Lancashire
Year: 2024

description: In the project described in this thesis, computational fluid dynamics (CFD) was used comparatively with the traditional calculation approach to predict smoke behaviour in tall and long atrium geometries in order to review the empirical correlations used to this day. It is demonstrated that the empirical correlations specified in the regulations, design guides, and handbook for the industry, which were based on theory and experiments done for more than 30 to 45 years before, may not be applicable nowadays to large volumes and high atriums.
A number of correlations exist, related to cross-sectional area and height. Particular focus is made in one of the most widely used correlations for smoke mass flow rate and height defined in the National Fire Protection Association (NFPA). The constant, 0.28 used in NFPA 92: 2021 for smoke layer height applied in atrium design based on cross-sectional area is evaluated. A parametric study and the limits of applicability of the correlation are investigated by numerical analysis. A wide range of geometric characteristics, i.e., height, width, Sectional Aspect Ratio (SAR) and Plan Aspect Ratio (PAR) are investigated.
Based on the results of the current investigation, new constants are proposed to be used, namely 0.25 and 0.24 for 20-30 m and 40 m tall atrium respectively.
For long atriums, results from empirical equations for rectangular-base long atriums with different PAR have also been compared with a series of numerical simulations.
New constants 0.25 and 0.27 seem to better fit the numerical results for 10-20 m and 30-40 m long atriums. A simple table is presented for use by practitioner designers.
Current thesis results indicate that the constant is not universally applicable to atriums that are particularly high or long, and new correlations are applied with the aim of being used by fire safety engineers.
Some new results are also presented on the development of stratification in taller atria. There is an existing formula for this, valid for small atria, based upon the oxymoron of a temperature gradient. It was found that velocity profiles can identify where stratification will occur, and this influences the design strategy, such as not extracting gas above this height because it is not smoke.
TUTORING POST THE PANDEMIC ERA : USING ONLINE ORTON-GILLINGHAM LESSONS TO TEACH READING COMPREHENSION AND WORD RECOGNITION TO PRESCHOOL CHILDREN AT RISK FOR DYSLEXIA
Creators: name: Bothina Mohammed Hussien Ali
Publisher: name: Zenodo
Year: 2023

description: Purpose: The purpose of this study was to gain insight into the potential effects of online Orton-Gillingham-based instruction on improving some reading skills among children identified at risk for dyslexia. Methods: This study employed a quantitative approach using a quasi-experimental, pre-test and post-test and follow up design to investigate the effects of Orton-Gillingham-based instruction on reading comprehension and word recognition among preschool children at risk for dyslexia. Sixty children were chosen. Children received 3 training sessions a week, lasting between 40 and 45 min: (10) minutes for auditory training, (15) minutes for visual training, (10) for motor training and (10) minutes for pairing training. Results: The results indicated that using Orton-Gillingham method increased reading comprehension and word recognition among Arabic-speaking children at risk for dyslexia. Conclusion: Online Orton-Gillingham-based instruction was effective in improving some reading skills among children identified at risk for dyslexia.
Probleme der Rechtssprache und der Begrifflichkeit bei Menschenrechten aus feministischer Sicht
Creators: name: Barker, Isabelle
name: Puar, Jasbir K.
Publisher: name: Concilium
Year: 1970

description: Concilium, Bd. 38 Nr. 5 (2002): Concilium: Internationale Zeitschrift für Theologie, Band 38, Heft 5
Feynman checkers: the probability to find an electron vanishes nowhere inside the light cone
Creators: name: Novikov, Ivan
Publisher: name: arXiv
Year: 2020
Subjects: subject: Mathematical Physics (math-ph)
subject: Combinatorics (math.CO)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 82B20

description: We study Feynman checkers, the most elementary model of electron motion introduced by R. Feynman. For the model, we prove that the probability to find an electron vanishes nowhere inside the light cone. We also prove several results on the average electron velocity. In addition, we present a lot of identities related to the model.
description: 17 pages
Late time Acceleration and Role of Skewness in Anisotropic models
Creators: name: Tripathy, S. K.
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We study cosmological models with anisotropy in expansion rates in the context of the recent observations predicting an accelerating universe. In the absence of any anisotropy in the cosmic fluid, it is shown that the role of skewness in directional Hubble rates is crucial in deciding the behavior of the model. We find that incorporation of skewness leads to a more evolving effective equation of state parameter.
description: 15 pages, 4 figures, Astrophysics Space Science, 2014
Controlled analysis of nanoparticle charge on mucosal and systemic antibody responses following pulmonary immunization
Creators: name: Ting, Jenny P. Y.
name: Shen, Tammy W.
name: DeSimone, Joseph M.
name: Fromen, Catherine A.
name: Robbins, Gregory R.
name: Kai, Marc P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: To our knowledge, no other nano-based vaccine delivery platform has directly assessed the effects of nanoparticle charge on pulmonary vaccination without affecting other physio/chemical particle characteristics and/or antigen loading. The Particle Replication in Non-Wetting Templates nanoparticle fabrication process is unique in that it allows for isolation of charge as the sole variable in these studies while maintaining all other physical and chemical parameters constant. We find that positively charged nanoparticles induce robust mucosal and systemic antibody responses following pulmonary administration, whereas negatively charged nanoparticles fail to do so. Therefore, our studies underscore the importance of considering nanoparticle charge as a critical design parameter when generating pulmonary-based vaccines and may have implications for particulate vaccination through other routes of administration.
Global higher integrability for minimisers of convex functionals with (p,q)-growth
Creators: name: Koch, Lukas
Publisher: name: arXiv
Year: 2020
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: We prove global $W^{1,q}(Ω,\mathbb{R}^m)$-regularity for minimisers of convex functionals of the form $\mathscr{F}(u)=\int_ΩF(x,Du)\mathrm{d} x$. $W^{1,q}(Ω,\mathbb{R}^m)$ regularity is also proven for minimisers of the associated relaxed functional. Our main assumptions on $F(x,z)$ are a uniform $α$-Hölder continuity assumption in $x$ and controlled $(p,q)$-growth conditions in $z$ with $q<\frac{(n+α)p}{n}$.
description: 31 pages, v2 with minor changes to the introduction and typos corrected
OVERVIEW OF EARLY PREGNANCY LOSS
Creators: name: Saja mohammed brik, AFNAN AHMED SHBELI, ABDAH ESSA HARDI, Ahmed Mohammed Huraysi, Eman Abkar Outhman Aqeely, RAWAN IBRAHIM BASHEERI, HADEEL MOHAMMED ALASRI, NORAH MOHAMMED YAHYA MOBARK, SALMA ALI TORKI, GHASON ALI TORKI, Anwar Ahmed Mansour, Wael Mohammed Majrabi, Ahmad Ali Dhubali, Khalid Ahmed Khormi
Publisher: name: Zenodo
Year: 2023

description: Introduction: It is typical to experience early pregnancy loss or the loss of an intrauterine pregnancy during the first trimester in clinical practice. A non-viable pregnancy up to 20 weeks of gestation is commonly called early pregnancy loss, sometimes known as miscarriage or spontaneous abortion. The most frequent type of pregnancy loss is early pregnancy loss, which happens in the first trimester (i.e., up to 12+6 weeks gestation). People who have experienced pregnancy loss are assessed to rule out any disease that needs immediate medical attention, and they are then given advice on the various therapy choices, including expectant, pharmaceutical, and surgical treatments. Obstetricians and gynecologists should be familiar with the use of various diagnostic techniques to distinguish between viable and unviable pregnancies and should be able to provide patients with the complete spectrum of therapeutic choices, including expectant, medicinal, and surgical management.
Aim of the study: The objective of the review is to identify miscarriage-related emergencies, outline typical history, physical, and laboratory evaluation, summarise available management options, and outline interprofessional team strategies for enhancing care coordination and patient communication.
Methodology: The present review is a comprehensive research of PUBMED since the year 1995 to 2022.
Conclusion: A pregnancy loss before 20 weeks gestation is referred to as Early loss of pregnancy. Early loss of pregnancy losses occur before 12 weeks of gestation as a result of chromosomal abnormalities. Smoking, being overweight, and having high blood pressure in the mother can all raise the risk of miscarriage. There is evidence that older mothers are more likely to miscarry, with rates for those over 40 reaching 74%. To ascertain whether a pregnancy is viable, transvaginal ultrasound evaluation is crucial. All three treatment methods (medical, surgical, or expectant management) have been shown to be equally safe and successful for women without co-morbid disorders.
Keywords: Early loss of pregnancy, ultrasound, emergency management
Dengue virus infection elicits highly polarized CX3CR1 + cytotoxic CD4 + T cells associated with protective immunity
Creators: name: Weiskopf, Daniela
name: Kolla, Ravi V.
name: De Silva, Aruna D.
name: Peters, Bjoern
name: Crotty, Shane
name: de Silva, Aravinda M.
name: Sidney, John
name: Sette, Alessandro
name: Bangs, Derek J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Infections with any of the four dengue virus serotypes (DENV 1–4) are the most prevalent and rapidly spreading mosquito-borne viral infections in humans. There is no treatment or vaccine currently available. We found that the virus-specific cells display a highly polarized cytotoxic phenotype that correlated with expression of a protective HLA DR allele. Although the occurrence of cytotoxic CD4+ T cells in humans has been described in the context of some chronic viral infections, to our knowledge, this is the first report of ex vivo cytotoxic CD4+ activity after exposure with an acute virus. These results will help shed light on the specific role of CD4+ T cells in DENV infection and may help in finding a correlate of protection.
Migration von Haushaltshilfen und Geschlechterungleichheiten in der neuen globalen Wirtschaft
Creators: name: Parreñas, Rhacel Salazar
Publisher: name: Concilium
Year: 1970

description: Concilium, Bd. 38 Nr. 5 (2002): Concilium: Internationale Zeitschrift für Theologie, Band 38, Heft 5
An Inverse Problem for the Relativistic Boltzmann Equation
Creators: name: Balehowsky, Tracey
name: Kujanpää, Antti
name: Lassas, Matti
name: Liimatainen, Tony
Publisher: name: arXiv
Year: 2020
Subjects: subject: Analysis of PDEs (math.AP)
subject: Mathematical Physics (math-ph)
subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We consider an inverse problem for the Boltzmann equation on a globally hyperbolic Lorentzian spacetime $(M,g)$ with an unknown metric $g$. We consider measurements done in a neighbourhood $V\subset M$ of a timelike path $μ$ that connects a point $x^-$ to a point $x^+$. The measurements are modelled by a source-to-solution map, which maps a source supported in $V$ to the restriction of the solution to the Boltzmann equation to the set $V$. We show that the source-to-solution map uniquely determines the Lorentzian spacetime, up to an isometry, in the set $I^+(x^-)\cap I^-(x^+)\subset M$. The set $I^+(x^-)\cap I^-(x^+)$ is the intersection of the future of the point $x^-$ and the past of the point $x^+$, and hence is the maximal set to where causal signals sent from $x^-$ can propagate and return to the point $x^+$. The proof of the result is based on using the nonlinearity of the Boltzmann equation as a beneficial feature for solving the inverse problem.
description: 60 pages. 4 figures. In this version, we have have improved the presentation of Section 4, which includes added motivation for Definition 4.1. We have also added more exposition in the introduction, in particular a more thorough discussion of Definition 1.2. Minor typos were fixed throughout the paper. This version coincides with the published version of our work, to appear in CMP
Individual project on theme "Thermus Brock & Freeze" (MOOC: CompTech in biology)
Creators: name: Maslov, Roman
Publisher: name: Zenodo
Year: 2023

description: Данный кейс является результатом реализации индивидуального проекта Романа Маслова по теме "Thermus Brock & Freeze" в рамках онлайн курса "Компьютерные технологии в биологии" (автор – А.В. Ваганов) (https://stepik.org/course/60859/promo)
Possible role of coronal streamer as magnetically-closed structure in shock-induced energetic electrons and metric type II radio bursts
Creators: name: Kong, Xiangliang
name: Chen, Yao
name: Guo, Fan
name: Feng, Shiwei
name: Wang, Bing
name: Du, Guohui
name: Li, Gang
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Two solar type II radio bursts, separated by ~24 hours in time, are examined together. Both events are associated with coronal mass ejections (CMEs) erupting from the same active region (NOAA 11176) beneath a well-observed helmet streamer. We find that the type II emissions in both events ended once the CME/shock fronts passed the white-light streamer tip, which is presumably the magnetic cusp of the streamer. This leads us to conjecture that the closed magnetic arcades of the streamer may play a role in electron acceleration and type II excitation at coronal shocks. To examine such a conjecture, we conduct a test-particle simulation for electron dynamics within a large-scale partially-closed streamer magnetic configuration swept by a coronal shock. We find that the closed field lines play the role of an electron trap, via which the electrons are sent back to the shock front for multiple times, and therefore accelerated to high energies by the shock. Electrons with an initial energy of 300eV can be accelerated to tens of keV concentrating at the loop apex close to the shock front with a counter-streaming distribution at most locations. These electrons are energetic enough to excite Langmuir waves and radio bursts. Considering the fact that most solar eruptions originate from closed field regions, we suggest that the scenario may be important to the generation of more metric type IIs. This study also provides an explanation to the general ending frequencies of metric type IIs at or above 20-30 MHz and the disconnection issue between metric and interplanetary type IIs.
description: 27 pages, 10 figures, accepted by ApJ
Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade
Creators: name: Wu, Bingruo
name: Xu, Longquan
name: Grant, Ruriko
name: Hiller, Sylvia
name: Hathaway, Catherine K.
name: Kim, Hyung-Suk
name: Kakoki, Masao
name: Smithies, Oliver
name: Chang, Albert S.
name: Bagnell, C. Robert
name: Rojas, Mauricio
name: Madden, Victoria J.
name: Hagaman, John R.
name: Zhou, Bin
name: Li, Feng
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Congestive heart failure develops in human patients and experimental animals when the left ventricle becomes dilated. In the present study, mice were generated having graded genetic levels of endothelin-1 from 20% normal to 350% normal by modifying the 3′ untranslated region of the endothelin-1 gene. The 20% and 65% hypomorphs develop dilated cardiomyopathy, whereas the 350% hypermorph has a hypertrophic heart. Increases in superoxide levels and overexpression of matrix metalloproteinase 9 (MMP9) are involved in the development of the dilated cardiomyopathy in the 20% hypomorph. Our results show that endothelin-1 is critical for maintaining normal cardiac contractile function, for controlling superoxide and Mmp9 levels, and for ensuring that the myocardium has sufficient collagen to prevent overstretching.
Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins
Creators: name: Zimmerman, Seth P.
name: Guntas, Gurkan
name: Williams, Tishan
name: Hallett, Ryan A.
name: Bear, James E.
name: Yumerefendi, Hayretin
name: Kuhlman, Brian
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Photoactivatable proteins are powerful tools for studying biological processes. Light-induced dimers are especially useful because they can be turned on and off with high spatial and temporal resolution in living systems, allowing for control of protein localization and activity. Here, we develop and apply methods for identifying mutations that improve the effectiveness of a light-induced dimer. The engineered switch is modular, can be used in most organisms, has more than 50-fold change in binding affinity upon light stimulation, and can be used to initiate signaling pathways in a specific region of a cell.
A Primer on HIBS -- High Altitude Platform Stations as IMT Base Stations
Creators: name: Euler, Sebastian
name: Lin, Xingqin
name: Tejedor, Erika
name: Obregon, Evanny
Publisher: name: arXiv
Year: 2021
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Mobile communication via high-altitude platforms operating in the stratosphere is an idea that has been on the table for decades. In the past few years, however, with recent advances in technology and parallel progress in standardization and regulatory bodies like 3GPP and ITU, these ideas have gained considerable momentum. In this article, we present a comprehensive overview of HIBS - High Altitude Platform Stations as IMT Base Stations. We lay out possible use cases and summarize the current status of the development, from a technological point of view as well as from standardization in 3GPP, and regarding spectrum aspects. We then present preliminary system level simulation results to shed light on the performance of HIBS. We conclude with pointing out several directions for future research.
description: 7 pages, 5 figures
Electronic waiting-time distribution of a quantum-dot spin valve
Creators: name: Sothmann, Björn
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We discuss the electronic waiting-time distribution of a quantum-dot spin valve, i.e. a single-level quantum dot coupled to two ferromagnetic electrodes with magnetizations that can point in arbitrary directions. We demonstrate that the rich transport physics of this setup such as dynamical channel blockade and spin precession in an interaction-driven exchange field shows up in the waiting-time distribution and analyze the conditions necessary to observe the various effects.
description: 7 pages, 5 figures, published version
Asymptotic Scattering by Poissonian Thermostats
Creators: name: Komorowski, Tomasz
name: Olla, Stefano
Publisher: name: arXiv
Year: 2021
Subjects: subject: Mathematical Physics (math-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences
subject: 82C70

description: We consider an infinite chain of coupled harmonic oscillators with a Poisson thermostat at the origin. In the high frequency limit, we establish the reflection-transmission-scattering coefficients for the wave energy scattered off the thermostat. Unlike the case of the Langevin thermostat [5], in the macroscopic limit the Poissonian thermostat scattering generates a continuous cloud of waves of frequencies different from that of the incident wave.
Die Globalisierung und die Verletzung von Frauen- und Menschenrechten
Creators: name: Jarl, Ann-Cathrin
Publisher: name: Concilium
Year: 1970

description: Concilium, Bd. 38 Nr. 5 (2002): Concilium: Internationale Zeitschrift für Theologie, Band 38, Heft 5
Essential role for polymerase specialization in cellular nonhomologous end joining
Creators: name: Aza, Ana
name: Mieczkowski, Piotr A.
name: Pryor, John M.
name: Strom, Christina
name: Ramsden, Dale A.
name: Blanco, Luis
name: Waters, Crystal A.
name: Asagoshi, Kenjiro
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Nonhomologous end joining (NHEJ) is a DNA double-strand break repair pathway required for development of the adaptive immune response, maintenance of cellular proliferative capacity, and the response to several commonly used cancer treatments. A major challenge faced by this pathway is that chromosome breaks can have dirty end structures, making them difficult to repair. We show here that two mammalian DNA polymerases have an unexpectedly pivotal role in helping resolve such ends. Each is proficient in different contexts and has a differing impact on repair fidelity. This work sheds light on how NHEJ has evolved to be flexible during repair and identifies two polymerases as critical for this process.
MPEC 2023-R55 : 2023 RF1
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 RF1

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
On the geometry and representation theory of isomeric matrices
Creators: name: Nagpal, Rohit
name: Sam, Steven V
name: Snowden, Andrew
Publisher: name: arXiv
Year: 2021
Subjects: subject: Representation Theory (math.RT)
subject: Commutative Algebra (math.AC)
subject: FOS: Mathematics
subject: 13E05, 13A50

description: The space of $n \times m$ complex matrices can be regarded as an algebraic variety on which the group ${\bf GL}_n \times {\bf GL}_m$ acts. There is a rich interaction between geometry and representation theory in this example. In an important paper, de Concini, Eisenbud, and Procesi classified the equivariant ideals in the coordinate ring. More recently, we proved a noetherian result for families of equivariant modules as $n$ and $m$ vary. In this paper, we establish analogs of these results for the space of $(n|n) \times (m|m)$ isomeric matrices with respect to the action of ${\bf Q}_n \times {\bf Q}_m$, where ${\bf Q}_n$ is the automorphism group of the isomeric structure (commonly known as the "queer supergroup"). Our work is motivated by connections to the Brauer category and the theory of twisted commutative algebras.
description: 27 pages
Treatment decision based on unilateral index from non-ACTH stimulated and ACTH stimulated adrenal vein sampling-Supplemental materials
Creators: name: Zhang, Xizi
name: Shu, Xiaoyu
name: Yang, Jun
name: Cheng, Qingfeng
name: Du, Zhipeng
name: Song, Ying
name: Yang, Yi
name: Hu, Jinbo
name: Long, Jian
name: Wu, Feifei
name: Li, Qifu
name: Yang, Shumin
Publisher: name: figshare
Year: 2023
Subjects: Endocrinology

description: The supplemental data of the manuscript: Treatment decision based on unilateral index from non-ACTH stimulated and ACTH stimulated adrenal vein sampling
A Multi-Scale Analysis Scheme on Abelian Groups with an Application to Operators Dual to Hill's Equation
Creators: name: Damanik, David
name: Goldstein, Michael
name: Lukic, Milivoje
Publisher: name: arXiv
Year: 2014
Subjects: subject: Spectral Theory (math.SP)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We present an abstract multiscale analysis scheme for matrix functions $(H_{\varepsilon}(m,n))_{m,n\in \mathfrak{T}}$, where $\mathfrak{T}$ is an Abelian group equipped with a distance $|\cdot|$. This is an extension of the scheme developed by Damanik and Goldstein for the special case $\mathfrak{T} = \mathbb{Z}^ν$. Our main motivation for working out this extension comes from an application to matrix functions which are dual to certain Hill operators. These operators take the form $H_{\tildeω}=-\frac{d^2}{dx^2} + \varepsilon U(\tildeωx)$, where $U$ is a real smooth function on the torus $\mathbb{T}^ν$, $\tildeω\in \mathbb{R}^ν$ is a vector with rational components, and $\varepsilon$ is a small parameter. The group in this particular case is the quotient $\mathfrak{T} = \mathbb{Z}^ν/\{m\in\mathbb{Z}^ν:m\tildeω=0\}$. We show that the general theory indeed applies to this special case, provided that the rational frequency vector $\tildeω$ obeys a suitable Diophantine condition in a large box of modes. Despite the fact that in this setting the orbits $k + mω$, $k \in \mathbb{R}$, $m\in\mathbb{Z}^ν$ are not dense, the dual eigenfunctions are exponentially localized and the eigenvalues of the operators can be described as $E(k+mω)$ with $E(k)$ being a "nice" monotonic function of the impulse $k \ge 0$. This enables us to derive a description of the Floquet solutions and the band-gap structure of the spectrum, which we will use in a companion paper to develop a complete inverse spectral theory for the Sturm-Liouville equation with small quasi-periodic potential via periodic approximation of the frequency. The analysis of the gaps in the range of the function $E(k)$ plays a crucial role in this approach.
description: 53 pages. This paper generalizes the results from arXiv:1209.4331 to general Abelian groups
Evidence for extensive horizontal gene transfer from the draft genome of a tardigrade
Creators: name: Goldstein, Bob
name: Messina, David N.
name: Glasscock, Jarret
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Despite fascinating scientists for over 200 years, little at the molecular level is known about tardigrades, microscopic animals resistant to extreme stresses. We present the genome of a tardigrade. Approximately one-sixth of the genes in the tardigrade genome were found to have been acquired through horizontal transfer, a proportion nearly double the proportion of previous known cases of extreme horizontal gene transfer (HGT) in animals. Foreign genes have impacted the composition of the tardigrade genome: supplementing, expanding, and replacing endogenous gene families, including those families implicated in stress tolerance. Our results extend recent findings that HGT is more prevalent in animals than previously suspected, and they suggest that organisms that survive extreme stresses might be predisposed to acquiring foreign genes.
MPEC 2024-S04 : 2024 RR14
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Simple and reliable method of conductive SPM probe fabrication using carbon nanotubes
Creators: name: Dremov, Vyacheslav
name: Fedoseev, Vitaly
name: Fedorov, Pavel
name: Grebenko, Artem
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We demonstrate the procedure of Scanning Probe Microscopy (SPM) conductive probe fabrication with a single multi-walled carbon nanotube (MWNT) on a silicon cantilever pyramid. The nanotube bundle reliably attached to the metal-covered pyramid is formed using electrophoresis technique from the MWNT suspension. It is shown that the dimpled aluminium sample can be used both for shortening/modification of the nanotube bundle by applying pulse voltage between the probe and the sample, and for controlling the probe shape via Atomic Force Microscopy (AFM) imaging the sample. It allows to fabricate a probe suitable for SPM imaging in the contact and modulation regimes. The majority of such probes are conductive with conductivity not degrading within hours of SPM imaging.
description: 6 pages, 7 figures
Evolutionary origins of hepatitis A virus in small mammals
Creators: name: Gmyl, Anatoly P.
name: Kuiken, Thijs
name: Lukashev, Alexander N.
name: Drexler, Jan Felix
name: Seggewiβ, Nicole
name: Dotzauer, Andreas
name: Leijten, Lonneke M.
name: Brünink, Sebastian
name: Vallo, Peter
name: Feng, Hui
name: Drosten, Christian
name: Lemon, Stanley M.
name: Rasche, Andrea
name: Corman, Victor M.
name: van den Brand, Judith M. A.
name: Ulrich, Rainer G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The origins of human hepatitis A virus (HAV) are unknown. We conducted a targeted search for HAV-related viruses in small mammals sampled globally and discovered highly diversified viruses in bats, rodents, hedgehogs, and shrews. We demonstrate that these viruses share unique biological features with HAV, including structural, genomic, antigenic, and pathogenic properties. We found evidence of major shifts of HAV-related viruses between mammalian hosts in the past, suggesting both an origin of this viral genus in small mammals and a zoonotic origin of human HAV. Our data show that risk assessments for emerging viruses can benefit greatly from the analysis of viral infection patterns that evolved within animal reservoirs.
Global temperatures and sunspot numbers. Are they related? Yes, but non linearly. A reply to Gil-Alana et al. (2014)
Creators: name: Scafetta, Nicola
Publisher: name: arXiv
Year: 2014
Subjects: subject: Atmospheric and Oceanic Physics (physics.ao-ph)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Geophysics (physics.geo-ph)
subject: FOS: Physical sciences

description: Gil-Alana et al. (Physica A: 396, 42-50, 2014) compared the sunspot number record and the temperature record and found that they differ: the sunspot number record is characterized by a dominant 11-year cycle while the temperature record appears to be characterized by a singularity or pole in the spectral density function at the zero frequency. Consequently, they claimed that the two records are characterized by substantially different statistical fractional models and rejected the hypothesis that sun influences significantly global temperatures. I show that: (1) the "singularity" or "pole" in the spectral density function of the global surface temperature at the "zero" frequency does not exist - it is a typical misinterpretation that discrete power spectra of non-stationary signals can suggest; (2) appropriate continuous periodograms clarify the issue and also show a signature of the 11-year solar cycle (amplitude <0.1 K), which since 1850 has an average period of about 10.4 year, and of many other natural oscillations; (3) the solar signature in the surface temperature record can be recognized only using specific techniques of analysis that take into account non-linearity and filtering of the multiple climate change contributions; (4) the post 1880-year temperature warming trend cannot be compared or studied against the sunspot record and its 11-year cycle, but requires solar proxy models showing short and long scale oscillations plus the contribution of anthropogenic forcings, as done in the literature. Multiple evidences suggest that global temperatures and sunspot numbers are quite related to each other at multiple time scales through complex and non-linear processes. Finally, I show that the prediction of a semi-empirical model for the global temperature based on astronomical oscillations and anthropogenic forcing proposed by Scafetta since 2009 has up to date been successful.
description: 21 pages, 6 figures
MICROSCOPE's constraint on a short-range fifth force
Creators: name: Bergé, Joel
name: Pernot-Borràs, Martin
name: Uzan, Jean-Philippe
name: Brax, Philippe
name: Chhun, Ratana
name: Métris, Gilles
name: Rodrigues, Manuel
name: Touboul, Pierre
Publisher: name: arXiv
Year: 2021
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The MICROSCOPE experiment was designed to test the weak equivalence principle in space, by comparing the low-frequency dynamics of cylindrical "free-falling" test masses controlled by electrostatic forces. We use data taken during technical sessions aimed at estimating the electrostatic stiffness of MICROSCOPE's sensors to constrain a short-range Yukawa deviation from Newtonian gravity. We take advantage of the fact that in the limit of small displacements, the gravitational interaction (both Newtonian and Yukawa-like) between nested cylinders is linear, and thus simply characterised by a stiffness. By measuring the total stiffness of the forces acting on a test mass as it moves, and comparing it with the theoretical electrostatic stiffness (expected to dominate), it is a priori possible to infer constraints on the Yukawa potential parameters. However, we find that measurement uncertainties are dominated by the gold wires used to control the electric charge of the test masses, though their related stiffness is indeed smaller than the expected electrostatic stiffness. Moreover, we find a non-zero unaccounted for stiffness that depends on the instrument's electric configuration, hinting at the presence of patch-field effects. Added to significant uncertainties on the electrostatic model, they only allow for poor constraints on the Yukawa potential. This is not surprising, as MICROSCOPE was not designed for this measurement, but this analysis is the first step to new experimental searches for non-Newtonian gravity in space.
description: Accepted for publication in CQG's MICROSCOPE special issue
Semantic Chemical Data Modeling using LinkML
Creators: name: Mungall, Christopher J
Publisher: name: Zenodo
Year: 2022
Subjects: semantic-chemistry
materials-science
linked-data
FAIR-data
chemrof
linkml

description: Demonstration of the applicability of the Linked Data Modeling Language and CHEMROF ( https://chemkg.github.io/chemrof/) for semantic chemical sciences. Presented at MADICES 2022. https://github.com/MADICES/MADICES-2022
The cluster environments of radio-loud AGN
Creators: name: Ineson, Judith
name: Croston, Judith
name: Hardcastle, Martin
name: Kraft, Ralph
name: Evans, Daniel
name: Jarvis, Matt
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Radio-loud AGN play an important rôle in galaxy evolution. We need to understand their properties, and the processes that affect their behaviour in order to model galaxy formation and development. We here present preliminary results of an investigation into the cluster environments of radio galaxies. We have found evidence of a strong correlation between radio luminosity and environment richness for low excitation radio galaxies, and no evidence of evolution of the environment with redshift. Conversely, for high excitation radio galaxies, we found no correlation with environment richness, and tentative evidence of evolution of the cluster environment.
description: 2 pages, 1 figure, to appear in the Proceedings of the IAU Symposium No. 313: Extragalactic jets from every angle, Galapagos, Ecuador, 15-19 September 2014, F. Massaro, C. C. Cheung, E. Lopez, and A. Siemiginowska (Eds.), Cambridge University Press