cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Techlash in Times of Corona
Creators: name: Seidl, Timo
Publisher: name: Zenodo
Year: 2020
Subjects: Techlash
Corona virus

description: The Corona pandemic has made us all painfully aware of how dependent we are on tech companies. This should not put an end to critical debates around tech regulation but reinforce the argument to treat these companies as what they are: public utilities.
Marine microbial community structure assessed from combined metagenomic analysis and ribosomal amplicon deep-sequencing
Creators: name: Denonfoux, Jeremie
name: Viscogliosi, Eric
name: Christaki, Urania
name: Genitsaris, Savvas
name: Monchy, Sebastien
name: Ferreira, Stephanie
name: Kormas, Konstantinos Ar.
name: Telesphore Sime-Ngando
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Genetics
subject: Microbiology

description: ABSTRACTThe microbial taxonomic composition of the three domains of life in two coastal plankton samples was assessed by random total community metagenomic sequencing and PCR-based rDNA amplicon deep-sequencing in order to compare the resulting diversity and investigate possible limitations and complementarities of each method. The various universal primer sets, used to amplify different hypervariable rDNA regions, revealed the same major high-level taxonomic groups in Bacteria and unicellular Eukaryota, and showed a scarce Archaea apparent richness. However, significant differences were found between the different primer sets (p-value < 0.05, with the Kolmogorov–Smirnov test), regarding both operational taxonomic unit (OTU) richness and relative abundance of the major high-level taxonomic groups detected. Based on the metagenomic approach, the phylum Bacteroidetes dominated the prokaryotic community, followed by Proteobacteria, while the detected eukaryotic unicellular taxa belonged to the groups of Alveolata, Fungi, Chlorophyta, Stramenopiles and Phaeophyceae. These groups were found to carry genes typically found in microbial communities, which are linked to DNA, RNA and protein metabolism and the synthesis of nucleotides, amino acids, carbohydrates and vitamins. Although our findings suggest that the total community metagenomic approach can provide a more comprehensive picture of the planktonic microbial community structure, a number of issues associated with this approach emerged. These issues include the still relatively high cost compared to amplicon sequencing, the possible low coverage of the full marine diversity, the insufficiency of databases for other gene markers than the small subunit gene, and the bias towards bacterial sequences because of their higher abundance relative to eukaryotes in marine environments.RESPONSIBLE EDITOR Torsten Struck
title: Simulative investigation of rubber damper elements for planetary touch-down bearings
Creators: name: Schüssler, Benedikt
name: Hopf, Timo
name: Rinderknecht, Stephan
Publisher: name: PAS, Division IV Technical Sciences
Year: 2022

description: Designing touch-down bearings (TDB) for outer rotor flywheels operated under high vacuum conditions constitutes a challenging task. Due to their large diameters, conventional TDB cannot suited well, and a planetary design is applied, consisting of a number of small rolling elements distributed around the stator. Since the amplitude of the peak loads during a drop-down lies close to the static load rating of the bearings, it is expected that their service life can be increased by reducing the maximum forces. Therefore, this paper investigates the influence of elastomer rings around the outer rings in the TDB using simulations. For this purpose, the structure and the models used for contact force calculation in the ANEAS simulation software are presented, especially the modelling of the elastomers. Based on the requirements for a TDB in a flywheel application, three different elastomers (FKM, VMQ, EPDM) are selected for the investigation. The results of the simulations show that stiffness and the type of material strongly influence the maximum force. The best results are obtained using FKM, leading to a reduction of the force amplitude in a wide stiffness range.
IN03174 Anurādhapura Stone Steps near 'Burrows' Pavilion' Inscription 3
Creators: name: Paranavitana, S.
Publisher: name: Zenodo
Year: 2020
Subjects: IN03174
Epigraphia Zeylanica
Anuradhapura

description: IN03174 Anurādhapura Stone Steps near ‘Burrows’ Pavilion’ Inscription 3 - Transcript and Translation Source: Paranavitana, S. (1934–41). ‘No. 16. Inscriptions on the Steps near ‘Burrows’ Pavilion’ at Anurādhapura,’ Epigraphia Zeylanica 4, pp. 136–141.
title: 01_0665
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Coding Instrumental Gestures. Towards a quantitative description of instrumental gestures in excitation-continuous musical instruments
Creators: name: Maestre, Esteban
Publisher: name: Zenodo
Year: 2006

description: The subject of this work is the exploration of methods for the characterization of instrumental gestures in music performance. More concretely, we face the case of excitation-continuous monophonic musical instruments. Instrumental gestures are understood here as the actions applied by a musician to produce the sound conveying the musical message contained in the piece or composition being performed. These actions have been measured either from the recorded audio or from physical movement measurements. After surveying some relevant research carried out in the field of instrumental gesture analysis in music performance, as well as the control techniques applied in some of state-of-the-art synthesis trends, we propose some approaches for describing quantitatively instrumental gestures as temporal contours of variables belonging to both the sound domain and the physical action domain, with the final aim of improving existing synthesis methods and opening new ways of gestural synthesis.
Interdonato lemon from Nizza di Sicilia (Italy): chemical composition of hexane extract of lemon peel and histochemical investigation
Creators: name: Salvo, Andrea
name: Bruno, Maurizio
name: Vadalà, Rossella
name: Mangano, Valentina
name: Cicero, Nicola
name: Dugo, Giacomo
name: Torre, Giovanna Loredana La
name: Mottese, Antonio Francesco
name: Saija, Emanuele
name: Casale, Katia Ermina
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences

description: Considering that the determination of authenticity and of the geographical origin of food is a very challenging issue, in this study we studied by means of histological and histochemical analyses the famous Sicilian lemon known as ‘Interdonato Lemon of Messina PGI’. Since the protected geographical indication Interdonato lemon of Messina possesses high organoleptic properties, the composition of the hexane extract of lemon peel was determined by HRGC and HRGC–MS analyses and compared with that of lemon of different cultivars. The results obtained are informative of the oil’s quality and explain the variation of the lemon essential oil composition. Given the fundamental economic implications of any fraud, the aim of this study was to determine a fingerprint able to evaluate the authentication of the geographic origin in such way to prevent frauds in national and international markets.
title: Управление разработкой интернет-проектов
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2022

description: В учебном пособии раскрывается содержание основных разделов учебной дисциплины «Управление разработкой интернет-проектов»: жизненный цикл интернет-проектов, инфраструктура и жизненный цикл разработки веб-проекта, контент для сайтов, управление командой разработчиков и специалистов, современные сервисы создания лендингов и лонгридов, CMS-системы управления сайтом, подготовка технического задания на разработку сайта, создание сайта-портфолио и интернет-магазина, веб-аналитика, метрики эффективности интернет-проектов, основы Яндекс.Метрики (Google Analytics), usability и дизайн интернет-проектов. Издание содержит теоретический материал и практические задания для лекционных и семинарских занятий, контрольные вопросы по основным темам, тестовые задания. Книга освещает вопросы применения ряда сквозных технологий, приведенных в Национальной программе «Цифровая экономика Российской Федерации», таких как технологии хранения и анализа больших данных, технологии машинного обучения и когнитивные технологии. Подготовлено с учетом требований Федерального государственного образовательного стандарта высшего образования. Учебное пособие предназначено для студентов, обучающихся по направлению подготовки 42.03.01 «Реклама и связи с общественностью», изучающих дисциплины «Управление разработкой интернет-проектов», «Маркетинг», «Реклама в цифровой среде», «Управление спецпроектами в цифровой среде», а также может быть использовано при изучении дисциплин «Управление интернет-проектами», «Технологические основы разработки и управления интернет-проектами» по направлению подготовки 38.04.05 «Бизнес-информатика». Издание будет полезно слушателям курсов по повышению квалификации и маркетологам-практикам.
title: Fostering intrapreneurship in Scotland: internal and external factors, influences and tensions
Creators: name: Dooley-Nealis, Róisín
Publisher: name: University of Glasgow
Year: 2025

description: This research investigates how intrapreneurship is facilitated in Scottish organisations across different sectors, drawing upon four strands of literature: entrepreneurship, human resource management, organisational behaviour, and organisational theory. The overarching aim is to explore how intrapreneurship is understood and enabled in organisations, emphasising the internal organisational dynamics, as well as external shocks and influences. 

The study reviews literature across individual, team, and organisational levels affecting intrapreneurship while considering external environmental impacts, synthesising these strands into a conceptual model. A comparative multi-case study approach was employed, investigating three organisations in Scotland through semi-structured interviews and documentary analysis of organisational and government policies. Interviews were conducted with management and employees at each level in the case organisations. Thematic analysis and an abductive approach were adopted to identify and analyse recurring patterns informed by the conceptual framework. 

As intrapreneurship is a complex multilevel construct, institutional logics were adopted as a lens to allow for an in-depth understanding of sectoral and industry differences in the intrapreneurship pursuit to be examined. The empirical findings show the enabling mechanisms of intrapreneurship, along with organisational tensions and competing logics. It is evident that top-down antecedents or enabling conditions are necessary to enable bottom-up ‘organic’ intrapreneurial activity. The findings demonstrate the influence of unexpected external events, pushing organisations to pursue intrapreneurship, developing antifragility and facilitating organic intrapreneurship. A multilevel model of intrapreneurship is presented, which considers all influencing factors and enabling mechanisms in its facilitation. 

This research contributes to knowledge, policy and practice, building upon the growing body of research on intrapreneurship. It moves beyond the individual level of analysis to provide insights into the multilevel causal mechanisms that facilitate intrapreneurship, revealing the tensions organisations face in enabling it and emphasising the need to navigate these tensions and achieve harmony. Intrapreneurship is highlighted as a key driver of innovation in the cross-sectoral cases with the potential to create change from within existing organisations. Robust evidence is provided as to how intrapreneurship may unlock untapped potential in existing organisations in Scotland and further afield.
title: Особенности разработки и эксплуатации гражданских беспилотных авиационных систем с технологиями искусственного интеллекта в Арктической зоне Российской Федерации
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2022

description: Монография освещает вопросы применения таких сквозных технологий Национальной программы «Цифровая экономика Российской Федерации», как технологии компонентов робототехники и мехатроники, искусственный интеллект. Издание представляет собой результаты научно-аналитического исследования по разработке и эксплуатации беспилотных авиационных систем с системами искусственного интеллекта в регионах Арктической зоны Российской Федерации. Автором — внешним пилотом беспилотного воздушного судна — рассмотрены особенности конструкции беспилотных воздушных судов, правила использования на территории РФ, возможности использования в различных сферах и практика применения БВС на территориях Крайнего Севера. Книга предназначена для специалистов, работающих в промышленности в области создания соответствующих систем, научных сотрудников и аспирантов, специалистов сферы беспилотной авиации. Она будет полезна также и для студентов средних специальных и высших учебных заведений, обучающихся по профильным специальностям, в т.ч. 25.02.08 «Эксплуатация беспилотных авиационных систем», поскольку ее содержание соответствует программам специальных профессиональных дисциплин. Особая аудитория издания — руководители компаний — потенциальных заказчиков услуг с применением беспилотных воздушных судов.
Impact of soil solarization on the ciliate community structure of a greenhouse soil
Creators: name: Murase, Jun
name: Asakawa, Susumu
name: Shinohara, Yoko
name: Yokoe, Kazunori
name: Matsuda, Risa
name: Hashimoto, Tomoyoshi
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Biological Sciences
subject: Ecology
subject: Earth and Environmental Sciences
subject: Microbiology

description: Soil solarization is an ecologically friendly method of controlling various plant pathogens and pests, but also affects non-pathogenic members of the soil biota. Here, we studied the impact of soil solarization on the community structure of soil ciliates using a culture-independent molecular approach, namely denaturing gradient gel electrophoresis (DGGE) of targeted 18S rRNA gene fragments. Greenhouse soil with added organic fertilizers was solarized for 33 days at an average temperature of 47–48°C. Solarization caused a drastic change in the ciliate community. The variation between replicates was large, which suggested that the distribution of ciliates was spatially heterogeneous in the soil, probably due to their decreased numbers. In contrast, non-solarized soil had a stable and homogeneous ciliate community during the experimental period. In solarized soil, most of the original ciliate community recovered 76 days after solarization. Sequence analysis of DGGE fragments indicated that both r-selected and K-selected species of ciliates were affected by solarization but recovered with time after solarization. Our results demonstrated both the vulnerability and resilience of the ciliate community to soil solarization and also the utility of using molecular-based analysis of ciliate communities as bioindicators of soil stress caused by solarization.
title: 01_1830
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
title: Цифровые технологии в строительстве
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2022

description: Учебное пособие освещает вопросы применения в строительстве сквозной технологии «Новые производственные технологии TechNet», приведенной в Национальной программе «Цифровая экономика Российской Федерации». В издании обоснована объективность применения цифровых технологий в строительстве как продолжение системы автоматизированного проектирования (САПР) и инновационного информационного менеджмента с использованием технологии информационного моделирования (BIM/ТИМ). Цель учебного пособия — познакомить будущих инженеров с перспективами процесса диджитализации и примерами применения цифровых технологий для повышения эффективности и качества строительства, цифрового проекта производства работ и опыта 3D-печати. В книге содержатся основные требования по составу ПОС (проекта организации строительства), основам и порядку ведения строительного документооборота исполнительной документации при осуществлении строительства и требования, предъявляемые к актам освидетельствования скрытых работ, ответственных конструкций в мобильных приложениях. Подготовлено с учетом требований Федерального государственного образовательного стандарта высшего образования. Учебное пособие предназначено для студентов, обучающихся по направлениям подготовки 08.03.01, 08.04.01 «Строительство» и специальности 23.05.06 «Строительство железных дорог, мостов и транспортных тоннелей», изучающих дисциплину «ОПУС» («Организация, планирование и управление в строительстве»).
A simulation study to examine the sensitivity of the Pettitt test to detect abrupt changes in mean
Creators: name: Villarini, Gabriele
name: Mallakpour, Iman
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Earth and Environmental Sciences
subject: Molecular Biology
subject: Biochemistry

description: The Pettitt test is a non-parametric test that has been used in a number of hydroclimatological studies to detect abrupt changes in the mean of the distribution of the variable of interest. This test is based on the Mann-Whitney two-sample test (rank-based test), and allows the detection of a single shift at an unknown point in time. This test is often used to detect shifts in extremes because of the lack of distributional assumptions. However, the downside of not specifying a distribution is that the Pettitt test may be inefficient in detecting breaks when dealing with extremes. Here we adopt a Monte Carlo approach to examine the sensitivity of the Pettitt test in detecting shifts in the mean under different conditions (location of the break within the series, magnitude of the shift, record length, level of variability in the data, extreme vs non-extreme records, and pre-assigned significance level). These simulation results show that the sensitivity of this test in detecting abrupt changes increases with the increase in the magnitude of the shift and record length. The number of detections is higher when the time series represents the central part of the distribution (e.g. changes in the time series of medians), while the skill decreases as we move toward either low or high extremes (e.g. changes in the time series of maxima). Furthermore, the number of detections decreases as the variability in the data increases. Finally, abrupt changes are more easily detected when they occur toward the center of the time series.Editor D. Koutsoyiannis Associate editor K. Hamed
title: Investigate the regulatory effect of human IL-37 isoform a (IL-37a) on Toll-like receptor (TLR) response in vitro and in vivo
Creators: name: Ji, Yuan
Publisher: name: University of Glasgow
Year: 2020
Subjects: subject: IL-37, TLR, Salmonella infection.

description: Background: Interleukin-37 is a newly discovered member of the IL-1 superfamily, consisting of 5 isoforms (IL-37a-e) due to different RNA splicing. Current studies are only focused on IL-37b isoform and demonstrate that IL-37b is an important immunosuppressive cytokine in TLR response in inflammatory diseases. However, the function and importance of other isoforms is still unknown. Here we investigate the function of IL-37 isoform a (IL-37a) which has a unique nuclear localisation sequence (NLS) and elastase cleavage sites in the protein N-terminal, while also containing the same receptor binding domain as IL-37b in the C-terminal. Hypothesis: As IL-37a carries the same receptor-binding domain as IL-37b, the two isoforms may share the same receptor and signalling via similar pathway in the regulation of TLR function. However, the unique N-terminal domains may confer IL-37a additional function in nuclear translocation and gene regulation. Aims: 1. To produce IL-37a and IL-37b recombinant proteins and transgenic mice. (Chapter 3). 2. To investigate the regulatory effect of IL-37a on TLR response in vitro and in a disease model (Chapter 4). 3. To explore the underlying molecular mechanism by which IL-37a and IL-37b differently affect TLR4 response in immune cells using transcriptomic analysis (Chapter 5).
Association between HIC1 promoter methylation and solid tumor: A meta-analysis
Creators: name: Zhao, Tie
name: Afrifa, Justice
name: Wang, Dong
name: Yu, Jingcui
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2020
Subjects: HIC1
hypermethylation
tumor suppressor gene

description: The epigenetic silencing of tumor suppressor genes by promoter methylation plays an increasingly important role in cancer research. A number of studies have reported the contribution of HIC1 promoter methylation towards the occurrence and development of solid tumors, even though HIC1 promoter methylation has also been found in normal and benign tissue samples. We sought to perform a more accurate and comprehensive meta-analysis to assess the association between HIC1 promoter methylation and cancer risk. We searched and retrieved all published studies on HIC1 promoter methylation in PubMed, Google Scholar, Embase, Cochrane Library, and Web of Science databases. After two reviewers checked the studies and extracted the necessary data independently, the meta-analysis was performed using STATA 12.0 software. A total of 14 case-control studies (949 cancer patients, 282 benign, and 371 normal controls) were included in our study. We report a significantly elevated HIC1 promoter methylation in tumor samples compared to normal (OR = 7.02, 95 % CI 3.12-15.78, P < 0.001) and benign controls (OR = 2.69, 95 % CI 1.13-6.42, P = 0.025). Subgroup analysis stratified by ethnicity showed a significantly reduced heterogeneity among North American (I2 = 0.0 %, P = 0.502) and European (I2 = 33.7 %, P = 0.183) samples. In addition, heterogeneity was significantly reduced among MSP based detection method (I2 = 36.4 %, P = 0.139) when samples were stratified based on the methylation detection methods. The overall outcome demonstrated that HIC1 promoter methylation may be involved in the occurrence and development of solid tumors and has the potential to serve as an epigenetic maker in various specific tumors.
description: EXCLI Journal; 19:Doc476; ISSN 1611-2156
Supplementary figures and models details from The source of individual heterogeneity shapes infectious disease outbreaks
Creators: name: Elie, Baptiste
name: Selinger, Christian
name: Alizon, Samuel
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences
subject: Computational Biology

description: There is known heterogeneity between individuals in infectious disease transmission patterns. The source of this heterogeneity is thought to affect epidemiological dynamics but studies tend not to control for the overall heterogeneity in the number of secondary cases caused by an infection. To explore the role of individual variation in infection duration and transmission rate on parasite emergence and spread, while controlling for this potential bias, we simulate stochastic outbreaks with and without parasite evolution. As expected, heterogeneity in the number of secondary cases decreases the probability of outbreak emergence. Furthermore, for epidemics that do emerge, assuming more realistic infection duration distributions leads to faster outbreaks and higher epidemic peaks. When parasites require adaptive mutations to cause large epidemics, the impact of heterogeneity depends on the underlying evolutionary model. If emergence relies on within-host evolution, decreasing the infection duration variance decreases the probability of emergence. These results underline the importance of accounting for realistic distributions of transmission rates to anticipate the effect of individual heterogeneity on epidemiological dynamics.
Uncertainty and variability in human exposure limits – a chemical-specific approach for ciprofloxacin and methotrexate
Creators: name: Huijbregts, Mark A. J.
name: Oldenkamp, Rik
name: Ragas, Ad M. J.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 60506 Virology
subject: FOS: Biological sciences
subject: Cancer
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Pharmacology
subject: Genetics
subject: Medicine
subject: Engineering
subject: Biochemistry

description: Human exposure limits (HELs) for chemicals with a toxicological threshold are traditionally derived using default assessment factors that account for variations in exposure duration, species sensitivity and individual sensitivity. The present paper elaborates a probabilistic approach for human hazard characterization and the derivation of HELs. It extends the framework for evaluating and expressing uncertainty in hazard characterization recently proposed by WHO-IPCS, i.e. by the incorporation of chemical-specific data on human variability in toxicokinetics. The incorporation of human variability in toxicodynamics was based on the variation between adverse outcome pathways (AOPs). Furthermore, sources of interindividual variability and uncertainty are propagated separately throughout the derivation process. The outcome is a two-dimensional human dose distribution that quantifies the population fraction exceeding a pre-selected critical effect level with an estimate of the associated uncertainty. This enables policy makers to set separate standards for the fraction of the population to be protected and the confidence level of the assessment. The main sources of uncertainty in the human dose distribution can be identified in order to plan new research for reducing uncertainty. Additionally, the approach enables quantification of the relative risk for specific subpopulations. The approach is demonstrated for two pharmaceuticals, i.e. the antibiotic ciprofloxacin and the antineoplastic methotrexate. For both substances, the probabilistic HEL is mainly influenced by uncertainty originating from: (1) the point of departure (PoD), (2) extrapolation from sub-acute to chronic toxicity and (3) interspecies extrapolation. However, when assessing the tails of the two-dimensional human dose distributions, i.e. the section relevant for the derivation of human exposure limits, interindividual variability in toxicodynamics also becomes important.
Humanística e Teologia, v. 22 n. 2 (2001)
Creators: name: Humanística E Teologia
Publisher: name: Humanística e Teologia
Year: 2001

description: O cristianismo no limiar dos novos tempos...155-158 Europa, os seus fundamentos espirituais, ontem, hoje e amanhã...159-175 O cristianismo e a cultura portuguesa...177-188 A identidade da fé cristã perante o plurialismo religioso...189-214 A teologia moral, a tolerância e o pluralismo ético...215-228 A fé cristã, inspiradora de criação artística...229-234 Economia, globalização e conceito cristão de Justiça...235-248 Reflexão cristológica e pluralismo cultural: sabedoria ou profecia?...249-259 A fé num tempo de incerteza. A esperança num tempo de cepticismo. A caridade num tempo de individualismo...287-293 Esperança, fé e caridade...295-299
Humanística e Teologia, v. 22 n. 1 (2001)
Creators: name: Humanística E Teologia
Publisher: name: Humanística e Teologia
Year: 2001

description: Unidades pastorais: desafio ou ameaça...5-24 Carta 43, enviada às "Quarenta e duas cartas (que não de amor)" de Fátima Andresen...25-34 A Igreja e a modernidade: um símbolo de conforto - D. Miguel da Annunciação...35-54 Função profética da vida consagrada...55-72 A filiação divina como condição transcendental de representação...73-111 Friedrich Nietzsche: influência na cultura portuguesa...115-122
title: Swadesh 207 wordlist
Creators: name: LI, Qiang
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: Lamo
subject: mis

description: Conforms to: doi:10.34847/cocoon.49aefa90-8c1f-3ba8-a099-0ebefc6a2aa7
Karolinska Psychodynamic Profile for Sexual Disorders: KAPP-SD. A proposal for a psychodynamic rating scale for sexual disorders
Creators: name: Soldati, Lorenzo
name: Köhl, John
name: Abraham, Georges
name: Demicheli, Francesco Bianchi
name: Wilczek, Alexander
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Science Policy
subject: Marine Biology
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Physiology
subject: FOS: Biological sciences
subject: Medicine
subject: Biochemistry

description: Objective: Our first objective in this paper was to review the literature on psychodynamic rating scales of sexual disorders. Our second objective, based on the findings from our review, was to develop a psychodynamic rating scale for people with sexual disorders: the KAPP-SD. Method: We developed the KAPP-SD by modifying an existing psychodynamic rating scale, which assesses stable modes of mental functioning and character traits, the Karolinska Psychodynamic Profile (KAPP). We removed items 13 and 14 of the KAPP and replaced them with three other items—sexual fantasies, conceptions and role of gender identity, and conceptions and role of sexual orientation. These items are part of the assessment of an individual's sexuality and are used to evaluate a person with a sexual disorder psychodynamically. Results: The KAPP-SD, a modified version of the KAPP, can be found in the Appendix. Conclusion: We developed the KAPP-SD in order to help sex therapists make a rigorous psychodynamic evaluation of persons with sexual disorders, which would give information on the prognosis and on the type of treatment to offer.
title: Цифровое государственное управление
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2022

description: Учебное пособие освещает вопросы применения в государственном управлении сквозных технологий «Технологии хранения и анализа больших данных» и «Информационная безопасность и технологии доверенного взаимодействия», приведенных в Национальной программе «Цифровая экономика Российской Федерации». Цель настоящего издания — представить концептуальную основу цифровизации публичной сферы современного общества и государства, раскрыть принципы построения и функционирования электронного и цифрового государственного управления, технологии которых находят все большее применение в Российской Федерации, включая проактивные госуслуги и суперсервисы, платформенные решения, технологии работы с открытыми и данными, разработки в области искусственного интеллекта, дополненной реальности и умного наблюдения, оказывающие существенное влияние на эффективность государственного управления. В учебном пособии рассматриваются вопросы перехода к типовому автоматизированному рабочему месту государственного служащего и связанные с ним технологии роботизации автоматизированных процессов управления. Издание содержит вопросы и задания для самоконтроля, тесты по всем разделам, глоссарий ключевых терминов и понятий, способствующих развитию профессиональных компетенций специалиста и навыков практического применения цифровых технологий. Подготовлено с учетом требований Федерального государственного образовательного стандарта высшего образования. Предназначено для студентов высших учебных заведений, преподавателей и научных сотрудников, государственных и муниципальных служащих, а также для широкого круга лиц, интересующихся технологиями и ключевыми направлениями цифровизации государственного управления.
Numerical experiments of rogue waves with Benney-Luke equations
Creators: name: Choi, Junho
Publisher: name: Zenodo
Year: 2022

description: # User instructions Program that solves the Benney-Luke equations (BLE) on a 2D periodic domain using the Stormer-Verlet scheme. The simulation tracks the evolution of two or three line solitons as they interact, to produce a four or eight times higher splash than the initial height of each soliton. For more information, please refer to the paper "Numerical experiments on extreme waves through oblique-soliton interactions", written by J. Choi, O. Bokhove, A. Kalogirou, and M. A. Kelmanson. ## FILES The code consists of five files: - `BL_periodic.py` is the main file that solves BLE; - `initial_data.py` defines the initial conditions eta_0(x,y), and Phi_0(x,y); - `boundary_point.py` computes points to design a computational domain; - `call_energy.py` and `call_maximum.py` are used for plotting the evolution of energy and maximum, respectively. After the computation is finished, four sets of data are produced: - solutions eta and Phi in "*data/output.pvd*"; - evolution of energy against time in "*data/energy.csv*"; - evolution of maximum of eta against time in "*data/max.csv*"; - time in "*data/time.csv*". The computational data can be visualised as follows: - Solutions eta and Phi are pvd files that can be read with Paraview. - Time evolution of energy can be plotted by running file `call_energy.py`. - Time evolution of maximum of eta can be plotted by running file `call_maximum.py`. ## USAGE There are three Switches in `BL_periodic.py` which the user can modify: - soliton number: SP2 or SP3, corresponding to simulations of two- or three-soliton interations; - domain type: single or both, corresponding to singly (x-direction) or doubly (x- and y-directions) periodic domain; - basis type: 1, 2, 3, or 4 corresponding to continuous Galerkin basis of the respective order. To obtain the results and figures in the paper, the Switches should be chosen as follows: Figure | soliton number | domain type | basis type 8 | SP3 | single and both | CG2 9-11 | SP2 | single | CG1, CG2, and CG3 12-15 | SP3 | single | CG1, CG2, CG3, and CG4 To modify the initial condition, the user can change the values of the variables in sections Parameters, and Parameters for k_i in `BL_periodic.py`. 
DBStorm: A Cost-effective Approach for Generating Valid Workload to Test Transaction Processing
Creators: name: Anonymous
Publisher: name: Zenodo
Year: 2022
Subjects: transaction processing, testing, workload generation

description: This is the supplementary material of DBStorm, including five parts: 1. ./DBStorm.pdf is our extends paper, which describes the details of DBStorms. 2. ./DBStorm default configurations contains the default configurations of DBStorm. 3. ./YCSB-SQL is the detailed configurations of YCSB-SQL. 4. ./Bugs demonstrates the bugs found by DBStorm. 5. ./BugReporducer is the detailed reproduce step for several bugs found in TDB.
Computational Modeling of Expressive Music Performance New Machine Learning Approaches for Dealing With Real-World Data
Creators: name: Hazan, Amaury
Publisher: name: Zenodo
Year: 2006

description: We present a doctoral pre-thesis report focusing of inductive computational modeling of music performance.

 We first introduce the expressive performance phenomenon from various points of view musicology, music cognition, computer music and brain science. We then review the approaches for modeling this phenomenon with an emphasis on inductive models i.e. models built from real-world performance data. The process of building an expressive performance database from acoustical recording is explained.

 Then, we present a comparison of well-established data mining (DM) techniques for inducing models from this database. This comparison has several implications that show the limits of standard DM techniques for building expressive performance models. We then propose a new approach called Evolutionary Population of Generative Models (EPGM) based on Evolutionary Computation (EC) which is suitable for dealing with the issues that arise when using the standard DM paradigm for performance modeling. We introduce several strategies for biasing the model search towards useful solutions, and propose alternatives for evaluating the accuracy of the evolved models.

 We validate the results using the performance database presented above and study the impact of our design decisions. We discuss the potential implications this new method can have in the EC field. Finally, we present some conclusions and dress a proposal which has implications in both expressive music performance modeling, machine learning, and evolutionary computation fields.
Comparing the effect of non-medical mechanical restraint preventive factors between psychiatric units in Denmark and Norway
Creators: name: Zoffmann, Vibeke
name: Siersma, Volkert Dirk
name: Bak, Jesper
name: Sestoft, Dorte Maria
name: Almvik, Roger
name: Brandt-Christensen, Mette
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Science Policy
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Cell Biology

description: Background: The use of mechanical restraint (MR) is controversial, and large differences regarding the use of MR are often found among countries. In an earlier study, we observed that MR was used twice as frequently in Denmark than Norway. Aims: To examine how presumed MR preventive factors of non-medical origin may explain the differing number of MR episodes between Denmark and Norway. Methods: This study is a cross-sectional survey of psychiatric units. Linear regression was used to assess the confounding effects of the MR preventive factors, i.e. whether a difference in the impact of these factors is evident between Denmark and Norway. Results: Six MR preventive factors confounded [∆exp(B)> 10%] the difference in MR use between Denmark and Norway, including staff education (− 51%), substitute staff (− 17%), acceptable work environment (− 15%), separation of acutely disturbed patients (13%), patient–staff ratio (− 11%), and the identification of the patient's crisis triggers (− 10%). Conclusions: These six MR preventive factors might partially explain the difference in the frequency of MR episodes observed in the two countries, i.e. higher numbers in Denmark than Norway. One MR preventive factor was not supported by earlier research, the identification of the patient's crisis triggers; therefore, more research on the mechanisms involved is needed. Clinical implications: None of the six MR preventive factors presents any adverse effects; therefore, units in Denmark and Norway may consider investigating the effect of implementing, the identification of the patient's crisis triggers, an increased number of staff per patient, increased staff education, a better work environment and reduced use of substitute staff in practice.
Cognitive and executive functions, social cognition and sense of coherence in adults with fetal alcohol syndrome
Creators: name: Rangmar, Jenny
name: Sandberg, Annika Dahlgren
name: Aronson, Marita
name: Fahlke, Claudia
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Science Policy
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Physiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Medicine

description: Background: Primary disabilities in children with fetal alcohol syndrome (FAS) are the results of alcohol's teratogen effect on the fetal brain. Reduced cognitive and executive functions and social cognition are examples of such disabilities. Little is known about primary disabilities in adults with FAS as well as their sense of coherence (SoC). There is thus a need for knowledge about FAS in adulthood. Aims: To investigate cognitive and executive functions, social cognition and SoC in adults with FAS. Methods: Twenty adults with FAS (mean age: 30 years) were compared with 20 individuals matched on gender and age. Berg's Card-sorting Test-64, the Tower of Hanoi, Raven's Coloured Progressive Matrices, Digit Span, Faux Pas and the Swedish version of Antonovsky's Sense of Coherence Scale (SoC-29) were used. Results: The FAS group had a weak SoC and displayed deficits in the neuropsychological tests sensitive to cognitive and executive functions and social cognition. The FAS group's median SoC score was 112, lower than the comparison group's median of 133 (P < 0.001). The FAS group had median scores of 29.0 on Raven's Matrices. The median for Digit Span was 5 forwards and 3 backwards, lower than in the comparison group (P < 0.001). Conclusions: Reduced cognitive and executive functions and impaired social cognition are assumed to have a major impact on life for adults with FAS. We suggest that the findings showing that adults with FAS had a weak SoC, with particularly low scores on the manageability scale, reflect their experiences of living with those primary disabilities. Clinical implications: This study may enhance healthcare for individuals prenatally exposed to alcohol. In general, it contributes with knowledge about this group of individuals who need to be more visible in healthcare, and particularly, it demonstrates some of the neuropsychological disabilities they might have.
LIAISON "How to" Training Course. 12 hour / 4 module course
Creators: name: Aldis, Helen
name: Allamand, Ana
name: Osborn, Simone
Publisher: name: Zenodo
Year: 2022
Subjects: participatory innovation
co-creation
multi-actor
innovation systems

description: This four-module (12 hr) training course has been developed to share and disseminate key findings from the H2020 funded LIAISON project. It is designed for practitioners who are already involved in multi-actor projects or individuals who are interested in learning more about effective ways to work together in co-innovation projects. The course is designed over four three-hour sessions and includes a trainer’s guide, presentation materials, exercises, case studies and handouts. Supplementary information can be accessed from LIAISON toolbox here https://liaison2020.eu/; or by accessing the "LIAISON: Better Rural Innovation: Linking Actors, Instruments and Policies through Networks" community resources.
مصاحبه با مجله مدیریت ا رتباطات
Creators: name: Jamali, Hamid R.
Publisher: name: figshare
Year: 2015
Subjects: subject: Library and Information Studies
subject: FOS: Media and communications

description: مصاحبه مجله مدیریت ارتباطات در خصوص رسانه‌ها و ارتباطات، مصاحبه توسط الهه حسینی. صاحبه درباره جامعه اطلاعاتي و رسانه ها، مصاحبه توسط الهه حسيني، ماهنامه مديريت ارتباطات، شماره ۱۷، مهر ۱۳۹۰، ۶۵-۶۶.
title: Информационные технологии в зоотехнии
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2022

description: В учебном пособии изложены принципы и особенности традиционных и перспективных компьютерных технологий в зоотехнии. Рассмотрены структура, классификация и виды информационных систем в животноводстве. Показаны приемы освоения и работы с компьютерными программами по животноводству, в частности оптимизация кормления сельскохозяйственных животных, планирование кормовой базы с помощью компьютерных программ «Коралл» и управление стадом посредством решений «AfiFarm». Учебное пособие освещает вопросы применения в сельском хозяйстве ряда сквозных технологий, приведенных в Национальной программе «Цифровая экономика Российской Федерации», таких как технологии хранения и анализа больших данных, технологии беспроводной связи и «интернета вещей». Подготовлено с учетом требований Федерального государственного образовательного стандарта высшего образования. Предназначено для студентов, обучающихся в магистратуре по направлению подготовки 36.04.02 «Зоотехния» (профиль «Частная зоотехния, технология производства продуктов животноводства»), изучающих дисциплину «Информационные технологии в зоотехнии».