cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Multi-'omics comparison of lung cancers from current and never smokers
Creators: name: Thu, Kelsie L.
Publisher: name: University of British Columbia
Year: 2013

description: Lung cancer is the leading cause of cancer death worldwide and a better understanding of the molecular alterations driving tumour biology is required to improve patient prognosis. This is especially true for never smokers (NS), which account for up to 25% of lung cancer cases globally. As the population of current smokers (CS) decreases due to smoking cessation and prevention initiatives, in the coming decades NS and former smokers (FS) will comprise a greater proportion of cases. We used an integrative 'omics approach to study lung cancer genomes of CS and NS to elucidate differential mechanisms and patterns of gene and pathway disruption likely to contribute to lung tumourigenesis. Lung cancers in CS and NS exhibit different clinical features and are known to preferentially select specific mutations (e.g. EGFR, KRAS, EML4-ALK), suggesting they are distinct diseases. Thus, we hypothesize that lung tumours of CS and NS exhibit disparate patterns of molecular alterations on a genome wide scale, reflecting the assumption that they develop through the differential selection of genes and pathways. A large scale, multi-dimensional, genomics study has yet to be performed and holds great potential to reveal novel insights into the mechanisms of lung tumourigenesis in CS and NS. Therefore, we performed DNA copy number, methylation, gene expression and microRNA expression profiling on a panel of lung adenocarcinoma tumours from CS and NS in an attempt to characterize the genomic and epigenomic landscapes of these tumours. In addition to identifying commonly disrupted genes and pathways, our integrative genomic analysis revealed numerous differences between CS and NS lung tumours including: differing extents of copy number and methylation alterations, different patterns of miRNA disruption, and preferential disruption of genes and cellular pathways. Importantly, some of the prominently disrupted genes that drive deregulation of tumour promoting pathways may represent novel therapeutic targets and intervention points. Collectively, this work provides further evidence that lung tumours of CS and NS develop through different molecular alterations which suggests patients will benefit from specific management strategies tailored to their smoking status.
Advanced multi chip module solutions for RF and digital space applications: status and perspective
Creators: name: Comparini, M.C.
name: Di Marcantonio, U.
name: Feudale, M.
name: Piloni, V.
name: Suriani, A.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2005
Subjects: ING-INF/01 Elettronica

description: The evolution of space modules and equipment hardware is strictly related to the progress of enabling technologies in terms of available high reliable processes and devices, advanced interconnection and packaging techniques and high repeatability production systems. The evolution towards highly integrated microwave and digital hybrids implies an integrate study of electrical, thermal and mechanical properties and proper power dissipation and thermal management techniques. The paper will go through the last solutions conceived and applied by Alenia Spazio in its broad product portfolio for telecommunication, radar and scientific space electronics application.
Impact of RFIC integration of system and subsystem blocks on MCM solutions
Creators: name: Reedy, Ronald E.
name: Camparini, Massimo Claudio
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2005
Subjects: ING-INF/01 Elettronica

description: Wireless systems of all types, from mobile phones to satellites have developed based on a combination of integrated circuits (IC) and multi chip modules (MCM). Digital sections of these systems have benefited from increasing levels of integration at the IC level thanks to a seemingly endless ability of Si CMOS to scale itself. However, RF sections have, for a variety of reasons, evolved much more toward MCM solutions. The primary reason for this trend is that RF sections require a wide variety of subsystems that differ substantially from each other whereas virtually all digital subsystems can be constructed from Si CMOS. In addition, RF sections have substantial passive requirements for filtering, matching and tuning. However, MCM solutions are large and expensive when compared to a possible IC solution. In this paper we present a hybrid option: use of UltraCMOS® technology in subsystem-level RFIC integration to reduce size and cost of MCM system solutions. Examples from both commercial and satellite applications will be presented and discussed.
Physical properties of galactic winds using background quasars
Creators: name: Bouche, N.
name: Hohensee, W.
name: Vargas, R.
name: Kacprzak, G. G.
name: Martin, C. L.
name: Cooke, J.
name: Churchill, C. W.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Background quasars are potentially sensitive probes of galactic outflows provided that one can determine the origin of the absorbing material since both gaseous disks and strong bipolar outflows can contribute to the absorption cross-section. Using a dozen quasars passing near spectroscopically identified galaxies at $z\sim0.1$, we find that the azimuthal orientation of the quasar sight-lines with strong MgII absorption (with EW>0.3 Å) is bi-modal: about half the MgII sight-lines are aligned with the major axis and the other half are within 30deg. of the minor axis, showing that bipolar outflows contribute significantly to the MgII cross-section. This bi-modality is also present in the instantaneous star-formation rates (SFRs) of the hosts. For the sight-lines aligned along the minor axis, a simple bi-conical wind model is able to reproduce the observed MgII kinematics and the MgII dependence with impact parameter b, (EW $\propto b^{-1}$). Using our wind model, we can directly extract key wind properties such as the de-projected outflow speed $V_{out}$ of the cool material traced by MgII and the outflow rates. The outflow speeds are found to be 150-300 \kms, i.e. of the order of the circular velocity, and smaller than the escape velocity by a factor of ~2. The outflow rates are typically two to three times the instantaneous SFRs. Our results demonstrates how background quasars can be used to measure wind properties with high precision.
description: 16pages, 15 figures, accepted to MNRAS, accepted version
Stability of rank-3 Lazarsfeld-Mukai bundles on K3 surfaces
Creators: name: Lelli-Chiesa, Margherita
Publisher: name: arXiv
Year: 2011
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics

description: Given an ample line bundle L on a K3 surface S, we study the slope stability with respect to L of rank-3 Lazarsfeld-Mukai bundles associated with complete, base point free nets of type g^2_d on curves C in the linear system |L|. When d is large enough and C is general, we obtain a dimensional statement for the variety W^2_d(C). If the Brill-Noether number is negative, we prove that any g^2_d on any smooth, irreducible curve in |L| is contained in a g^r_e which is induced from a line bundle on S, thus answering a conjecture of Donagi and Morrison. Applications towards transversality of Brill-Noether loci and higher rank Brill-Noether theory are then discussed.
description: 29 pages, final version, to appear in Proc. Lon. Math. Soc
TX system-level analysis by behavioral modeling
of RF building blocks: the IEEE802.11a and
IEEE802.15.3a case studies
Creators: name: Cidronali, A.
name: Camprini, M.
name: Magrini, I.
name: Bertran, E.
name: Athanasopoulos, N.
name: Makri, R.
name: Cignani, R.
name: Vannini, G.
name: Portilla, J.
name: Casas, P.
name: Vryssas, K.
name: Samelis, A.
name: Manes, G.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2005
Subjects: ING-INF/01 Elettronica

description: The paper highlights some of the newest
results achieved in the framework of the Transmitter
Modeling for wideband access transmitters work package
within the IST-EU Network of Excellence TARGET. Two
cases of study have been considered to discuss the outcome,
namely the IEEE 802.11a WLAN and the IEEE 802.15.3a
UWB. A specific discussion about the subsystem modeling
requirements in terms of key parameters allow the
construction of subsystem models capable of numerical
efficiency and accuracy. The subsequent insertion of such
subsystem behavioral models allows fast and accurate cosimulations of complete transmitters for the performance
investigation.
A suggestion for simplifying the theory of asset prices
Creators: name: Cesari, Riccardo
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2005
Subjects: SECS-P/03 Scienza delle finanze

description: Using an ordinal approach to utility, in the spirit of Hicks (1962, 1967a), it is possible to greatly simplify the theory of
asset prices. The basic assumption is to summarize any probability distribution into its moments so that preferences
over distributions can be mapped into preferences over vectors of moments. This implies that assets, like Lancaster’s
(1966) consumption goods, are bundles of characteristics and can be directly priced, at the margin, in terms of the
market portfolio. Expected utility is not required and both St.Petersburg and Allais paradoxes may be easily solved.
The role of general and firm-specific training for new technology adoption and economic growth: a critical review
Creators: name: Antonietti, Roberto
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2005
Subjects: SECS-P/06 Economia applicata

description: Aim of this article is to present an overview of the main economic literature focusing on the issue of how technology adoptionand  the accumulation of technical skills by firms affects the aggregate performance of economic systems. Since the analysis is labour‐demand oriented, a differentiation between a ‘mainstream’ and a ‘non‐mainstream’ approach is supposed to be crucial, the first being consistent with the neoclassical paradigm of the firm and human capital, while the second with the Schumpeterian paradigm and the so called view of the firm as a ‘learning organization’. Going through the basic models, the paper argues that while the mainstream approach is primarily based on production costs analyses and the capacity of the maket and hierarchies to provide the specific skills in order  for workers to deal with new technologies, non‐mainstream approaches are mainly oriented to the analysis of dynamic competition,  entrepreneurial/managerial skills and within‐firm organizational learning processes that are necessary in order to cope with a changing environment.
Prospect theory and the law of small
numbers in the evaluation of asset prices
Creators: name: Luppi, Barbara
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2005
Subjects: SECS-P/03 Scienza delle finanze

description: We develop a model of one representative agent and one asset. The
agent evaluates the earnings according to Prospect Theory and he does
not know exactly the stochastic process generating earnings. While
the earnings are generated by a random walk process, the agent considers
a Markovian process, according to which firm’s earnings move
between two regimes, represented by a mean-reverting process and a
trend process, as in Barberis, Shleifer and Vishny (1998). We study
how an agent who is loss averse evaluates the price of a stock when
she takes into account the wrong stochastic process. This twofold departure
from rationality determines permanent effects on stock prices,
even in long run. First, the model shows that agent who evaluates
the asset according to Prospect Theory consistently underestimates
the asset, due to loss aversion bias. This is shown under two different
assumption regarding the functional form of utility. A kinked linear
utility function (as in Bernatzi and Thaler, 1985) and the original and
more general specification of Kahneman and Tversky (1979) are used.
The model allows to explain observed phenomenon in the cross-section
earnings return distribution. We solve this model and according to
Barberis et all (1998), we evaluate the framework by using artificial
data sets of earnings and prices simulated from the model. For plausible
range of parameter values, it generates the empirical predictions
of overreaction and underreaction observed in the data are explained.
Additional file 1 of Mutagenicity of carcinogenic heterocyclic amines in Salmonella typhimurium YG strains and transgenic rodents including gpt delta
Creators: name: Nohmi, Takehiko
name: Watanabe, Masahiko
Publisher: name: figshare
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1.
Additional file 7 of Metabolomics analysis reveals Embden Meyerhof Parnas pathway activation and flavonoids accumulation during dormancy transition in tree peony
Creators: name: Zhang, Tao
name: Yuan, Yanchao
name: Zhan, Yu
name: Cao, Xinzhe
name: Liu, Chunying
name: Zhang, Yuxi
name: Gai, Shupeng
Publisher: name: figshare
Year: 2020
Subjects: subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 7: Figure S2. Venn diagram of 4 comparative metabolites. (a) up-regulated metabolites. (b) down-regulated metabolites.
Monitoring team production by design
Creators: name: Bono, Giovanni
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2005
Subjects: SECS-P/08 Economia e gestione delle imprese

description: This work addresses the optimal design of the monitoring technology for
a team when collective liability can not form. It shows that the principal’s
optimal design choice is then to concentrate monitoring on the less
productive agent in a team. By controlling the less productive agent she
fully discipline the more productive. This result helps in studying the interplay
between the institutional set-up and the technological capabilities
of teams.
Investigation of the influence of asymmetric long chain ceramides [NP] and [AP] on stratum corneum lipid matrix architecture with neutron diffraction
Creators: name: Schmitt, Thomas
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2018
Subjects: subject: Haubarriere; Ceramide; Lipide; Stratum corneum; Lipidmatrix; Neutronendiffraktion
subject: barrier; Ceramides; Lipids; stratum corneum; Lipid matrix; Neutron diffraction
subject: 572

description: Die Oberste Hautschicht, Stratum corneum, stellt die wichtigste Barriere des Körpers gegenüber Schadfaktoren wie Pathogenen oder Chemikalien dar. In dieser Arbeit wurde die Nanostruktur der Lipidmatrix als wichtigste Struktur für diese Funktion untersucht. Die hierfür angewendete Methode der Neutronendiffraktion erlaubt eine Nanometer-genaue Auflösung der multilamellaren Struktur der Lipidmatrix. Der Fokus lag dabei auf den C24/18 Ceramiden [NP] und [AP], als zwei der häufigsten und damit vermutlich wichtigsten Moleküle der Lipidmatrix. Durch die Verwendung von Deuterium-markierten Ceramiden konnte auch die räumliche Organisation der andernfalls nicht detektierbaren Kohlenwasserstoffketten analysiert werden. Eine Struktur mit sich wiederholenden 5.45 nm langen Lamellen mit überlappenden C24 Ketten konnte gezeigt werden. Weiterhin konnte eine deutlich unterschiedliche Struktur für die beiden D- und L-Isomere des Ceramids [AP] gezeigt werden. Das nicht natürlich vorkommende L-Ceramid [AP] erzeugte dabei eine deutlich Kristallinere Struktur. Weiterhin wurde beobachtet, dass sich trotz des Zusatzes eines deutlich langkettigeren C46/18 Ceramids, einem Analog des natürlichen Ceramids [EOS], die lamellare struktur nicht nennenswert verändert.
description: The oppermost skin layer, stratum corneum, represents the most important barrier of the body against hazards like pathogens or chemicals. In this Thesis, the nanostructure of the lipid matrix as most important structure for this function was investigated. The method applied for this purpose, the neutron diffraction allows for a nanometre scale resolution of the multilamellar structure. The focus was on the C24/18 Ceramides [NP] and [AP], as two of the most abundant and thus most likely most important molecules of the lipid matrix. Due to the use of deuterium-labelled ceramides it was furthermore possible, to resolve the spatial organisation of the otherwise undetectable hydrocarbon chains. A structure consisting of repeating 5.45 nm long lamellae with overlapping C24 chains was described. Furthermore, it was possible, to show that the two D- and L-Isomers of the ceramide [AP] resulted in notably different structures. The not naturally occurring L-ceramide [AP] results in a more crystalline structure. Beyond that, it was possible, to show, that the lamellar structure is almost uninfluenced by the addition of a very long C46/18 Ceramide, an analogue of the natural ceramide [EOS].
Identifying Contributions to the Stellar Halo from Accreted, Kicked-Out, and In Situ Populations
Creators: name: Sheffield, Allyson A.
name: Majewski, Steven R.
name: Johnston, Kathryn V.
name: Cunha, Katia
name: Smith, Verne V.
name: Cheung, Andrew M.
name: Hampton, Christina M.
name: David, Trevor J.
name: Wagner-Kaiser, Rachel
name: Johnson, Marshall C.
name: Kaplan, Evan
name: Miller, Jacob
name: Patterson, Richard J.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: [Abridged] We present a medium-resolution spectroscopic survey of late-type giant stars at mid-Galactic latitudes of (30$^{\circ}\sim$-0.6) with some contribution from the metal-rich component of the nearby halo. Here we report first results for 1799 stars. The distribution of radial velocity (RV) as a function of l for these stars shows (1) the expected thick disk population and (2) local metal-rich halo stars moving at high speeds relative to the disk, that in some cases form distinct sequences in RV-$l$ space. High-resolution echelle spectra taken for 34 of these "RV outliers" reveal the following patterns across the [Ti/Fe]-[Fe/H] plane: seventeen of the stars have abundances reminiscent of the populations present in dwarf satellites of the Milky Way; eight have abundances coincident with those of the Galactic disk and more metal-rich halo; and nine of the stars fall on the locus defined by the majority of stars in the halo. The chemical abundance trends of the RV outliers suggest that this sample consists predominantly of stars accreted from infalling dwarf galaxies. A smaller fraction of stars in the RV outlier sample may have been formed in the inner Galaxy and subsequently kicked to higher eccentricity orbits, but the sample is not large enough to distinguish conclusively between this interpretation and the alternative that these stars represent the tail of the velocity distribution of the thick disk. Our data do not rule out the possibility that a minority of the sample could have formed from gas {\it in situ} on their current orbits.
description: 43 pages, 9 figures, 4 tables, published in the Astrophysical Journal
Copyleft vs copyright:
some competitive effects of Open
Source
Creators: name: Lanzi, Diego
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2005
Subjects: SECS-P/06 Economia applicata

description: In this paper, we study oligopolistic competition between closed and
open source softwares. By intersecting existing economic contributions on open source,
we propose a two stage game with perfect information and product differetiation in
which producers firstly set software's quality, then they determine prices (constrained
at zero for open source programs). In doing this, we explicitly model lock-in effects,
network externality components' of software quality as well as knowledge accumulation
in software use and implementation.
With respect to a monopolistic benchmark case, we argue that in duopoly a pro-
prietary sofware producer facing an open source software will reduce its selling price
whether: (i) its network of users is larger than open source's one and its consumers are
largely experienced on its program, (ii) it has a small network of un-skilled consumers.
In opposition, after open source software's emergence, proprietary software price does
augment if proprietary software users form a large, but poorly skilled network. Fur-
thermore, we show that, in all above cases, proprietary software quality increases
because of the existence of a open source alternative to a previouisly monopolistic
program.
Finally, by modeling knowledge accumulation processes through difference equa-
tions, we show that the ratio between closed and open source programs' opportunity
costs of software learning and deployment plays a crucial role in shaping market out-
comes. Until an open source software remains too complex and technical for unskilled
or time-scarse users, a shared market solution in which both softwares are adopted is
predicted. In contrast, if opportunity costs in learning and understanding open source
programs are remarkably low, or at least equal to opportunity costs of a closed source
software, then a open source dominance outcome (i.e. all software are open ones)
phases out.
High powered incentives and fraudulent behavior: stock
based versus stock option based compensation
Creators: name: Andergassen, Rainer
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2005
Subjects: SECS-P/06 Economia applicata

description: In this paper shareholders face the trade-off between providing managers
with incentives to exert beneficial effort and to engage in costly fraudulent activity. We solve
for the optimal compensation package, given that shareholders can either grant (restricted)
stock or stock options and given fixed average compensation costs. We show that if the negative
effect of fraud on the company’s value is sufficiently large then stock based compensation
is optimal. Otherwise, stock option based compensation is optimal. Furthermore, we show
that the fraud to effort ratio is increasing in the strike price and that the optimal strike price
is decreasing in the size of the negative effects of fraud on the company’s value.
Hot Electron and Pair Production from the Texas Petawatt Laser Irradiating Thick Gold Targets
Creators: name: Taylor, Devin
name: Liang, Edison
name: Clarke, Taylor
name: Henderson, Alexander
name: Chaguine, Petr
name: Wang, Xin
name: Dyer, Gilliss
name: Serratto, Kristina
name: Riley, Nathan
name: Donovan, Michael
name: Ditmire, Todd
Publisher: name: arXiv
Year: 2012
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Accelerator Physics (physics.acc-ph)
subject: Medical Physics (physics.med-ph)
subject: FOS: Physical sciences

description: We present data for relativistic hot electron production by the Texas Petawatt Laser irradiating solid Au targets with thickness between 1 and 4 mm. The experiment was performed at the short focus target chamber TC1 in July 2011, with laser energies around 50 J. We measured hot electron spectra out to 50 MeV which show a narrow peak around 10 - 20 MeV plus high energy exponential tail. The hot electron spectral shape differs from those reported for other PW lasers. We did not observe direct evidence of positron production above background.
description: HEDLA 2012 Conference Paper. submitted to HEDP. revised 1/28/2013. 18 pages. 10 figures
An exploration of the experience of accessing primary health care for people with schizophrenia
Creators: name: Hamaguchi, Christina
Publisher: name: University of British Columbia
Year: 2013

description: People with schizophrenia have been found to experience health inequities that lead to early morbidity and mortality. Primary health care is an approach to reducing health inequities for individuals with schizophrenia. The purpose of this study was to examine what it is like for individuals with schizophrenia when they access primary health care. Exploring these experiences from the client perspective highlighted areas in which change is needed to improve access. This study used a qualitative methodology, specifically interpretive description, to analyze the data from 6 in-depth interviews with individuals with schizophrenia. The results indicate a need to address the multiple effects of stigma, the importance of considering physical and mental health care holistically, and the need to acknowledge and address the multiple losses that individuals with mental illness experience.
A Female Musician or Dancer of Iron Age in Southern Italy?
Creators: name: Bellia, Angela
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2011
Subjects: L-ART/07 Musicologia e storia della musica
L-ART/08 Etnomusicologia

description: The excavations conducted by Paola Zancani Montuoro between 1963 and 1969 in the necropolis at
Macchiabate (Cosenza), an anonymous city that in the archaic period gravitated under Sybarite rule,
brought to light the Tomb T.60 that belonging to a woman that dated back to the VIII century B.C. The
things that were found, were distinguished, from other burial places in the same necropolis, for the
exceptional nature of the findings. This led to the theory that the dead woman was a person of importance
in that community. The funeral equipment, now kept in the Museo Archeologico Nazionale della
Sibaritide, consisted of ceramics, ornaments and bronze objects that were either worn by or placed
around the skeleton; amongst these were musical instruments and objects.
Under the dead woman’s elbow was a ‘ladden sistrum’ (19,8x11,3x1,8 cm) made up of 15 spirals held
together by two plates that terminated in a lateral volute. Above the musical instrument there was an
object consisting of seventeen little tubes (average diameter 7 mm and maximum length 96 mm) which, in
comparison with similar integral examples that had bells with clapper, found in Sicily, must have formed
the extremity of a rattle made of big rings, probably to be worn around the neck. Above there was a
musical object consisting of nine concentric elements (H. 40 cm.) which turned around an internal
support that has been lost. Above all these objects were two cymbals and a ‘raschiatoio’ made of forty
one rings. It was found in perfect condition which probably meant there had been a support inside the
object along which the rings could slide. It was probably made of perishable material. These objects were
probably produced locally and seemed to have been influenced by oriental handicraft.
At the moment there were no studies which give an interpretation of the presence of musical
instruments and objects in this part of Southern Italy which, on one hand, could be proof of cultural and
commercial exchanges in the Iron Age between the local population and the Orient. This is widely
documented by archaeological findings. On the other hand, it is evidence of a particular funeral rite and
a precise cultural sphere, to which the woman of Francavilla seems to have belonged and whose sacred
status is also denoted by the musical objects found among the funeral equipment.
Stereoselektive Pharmakokinetik und CYP2C19-Genotypisierung als Prädiktoren des Therapieerfolges einer Omeprazol-Therapie bei Patienten mit GERD, Entwicklung eines neuen Analyseverfahrens
Creators: name: Reiche, Ines
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2012
Subjects: subject: Arzneimitteldosis
subject: Online-Publikation
subject: Hochschulschrift
subject: 615

description: Der Protonenpumpenhemmer Omeprazol wird enantioselektiv über die Enzyme CYP3A4 und CYP2C19 metabolisiert, wobei CYP2C19 einem Genpolymorphismus unterliegt. Im Rahmen dieser Arbeit konnte erstmalig eine HPLC-Methode entwickelt werden, welche es ermöglicht, enantioselektiv sowohl Omeprazol als auch seine beiden Hauptmetabolite, 5-Hydroxyomeprazol und Omeprazol-Sulfon, quantitativ in humanem Serum zu bestimmen. Die Probenaufbereitung erfolgte mittels Festphasenextraktion. Nachfolgend fand die chirale Trennung im Normalphasen-Modus mit tandem-massenspektrometrischer Detektion statt, wobei die Ionisation durch Photonen unter Atmosphärendruck erreicht wurde. Mit Hilfe der entwickelten Analytik wurde eine klinische Pilotstudie durchgeführt, die keinen signifikanten Vorteil für die vorhergehende Bestimmung des CYP2C19-Genotyps vor einer Omeprazol-Therapie bei Patienten mit einer gastroösophagealen Refluxkrankheit (GERD) fand. Hingegen konnten zwei Fälle von dosisabhängigen, unerwünschten Arzneimittelwirkungen durch Protonenpumpenhemmer aufgeklärt werden, die in dieser Form zuvor noch nicht beschrieben wurden und die Bedeutung der Pharmakokinetik verdeutlichen.
CsCAT3, a catalase gene from Cucumis sativus, confers resistance to a variety of stresses to Escherichia coli
Creators: name: Zhou, Yong
name: Liu, Shiqiang
name: Yang, Zijian
name: Yang, Yingui
name: Jiang, Lunwei
name: Hu, Lifang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified

description: Catalase (CAT) is a key scavenging enzyme for the degradation of hydrogen peroxide (H2O2) and plays an important role in the tolerance to diverse abiotic stresses in many different organisms. In this study, we characterized the function of a catalase gene (CsCAT3) previously isolated from Cucumis sativus in the defence against a variety of stresses. Protein alignment and phylogenetic analysis revealed that CsCAT3 was clustered in the dicot group and shared 41%–95% identity with other plant CATs. Expression analyses revealed that the expression of CsCAT3 was induced by diverse abiotic stresses such as heat, polyethylene glycol, cold and NaCl treatment, as well as by signalling molecules such as abscisic acid (ABA) and H2O2. An Escherichia coli heterologous expression system was constructed to characterize the function of CsCAT3 in vitro. Its overexpression in E. coli could increase the tolerance to heat, cold, salinity and osmotic conditions. These results indicate that CsCAT3 plays important roles in abiotic stress tolerance and that CsCAT3 confers tolerance in E. coli recombinants against abiotic stresses, which may be due to the increased activities of antioxidant enzymes that reduce the oxidative damage caused by stress conditions.
Gli strumenti musicali nelle immagini della Grecia antica.
Percorso di didattica museale musicale
Creators: name: Bellia, Angela
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2009
Subjects: L-ART/07 Musicologia e storia della musica
L-ART/04 Museologia e critica artistica e del restauro

description: Questo percorso didattico è dedicato agli strumenti musicali della Grecia antica attraverso le immagini delle ceramiche attiche a figure nere e a figure rosse. Le scene musicali aiutano a conoscere i luoghi e i contesti dove la musica veniva praticata, gli strumenti più frequentemente utilizzati dagli esecutori, nonché la funzione comunicativa sociale della musica, rituale e simbolica. L’obiettivo educativo del percorso didattico è far conoscere la musica della Grecia antica attraverso le immagini che, sebbene non siano in grado di restituire i suoni andati irrimediabilmente perduti, consentono di ricostruire e di cogliere la funzione della musica nel passato. 
Inoltre, mira a realizzare uno strumento multimediale interattivo per Personal Computer su CD-ROM finalizzato alla creazione di segmenti di visita di un museo virtuale degli strumenti musicali della Grecia antica da inserire in un sito web (per esempio quello della scuola). Esso è uno strumento utile alla didattica per la presenza di più linguaggi (verbale-musicale-visivo-logico) in grado di favorire negli alunni processi cognitivi e metacognitivi. In tale prospettiva il percorso coniuga la comprensione dell’antico con le nuove tecnologie attraverso contenuti culturali digitali usati a fini didattici.
Mito, musica e rito nelle raffigurazioni musicali dei pinakes del Persephoneion di Locri Epizefirii (VI-V sec.a.C.)
Creators: name: Bellia, Angela
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2008
Subjects: L-ART/07 Musicologia e storia della musica
L-ANT/02 Storia greca
L-ANT/07 Archeologia classica

description: I pinakes locresi sono tavolette votive in terracotta del VI e V sec. a. C., per la maggior parte rinvenuti in frammenti, nel 1908, da Paolo Orsi, presso l’edicola tesauraria della Mannella a Locri Epizefirii, polis italiota che si distinse per la sua intensa attività cultuale e sacra e la vigile custodia di antichissime tradizioni mitiche e storiche. 
Nelle rappresentazioni dei coroplasti, talvolta veri artisti, l’ambiente locrese è individuabile attraverso la configurazione di templi dove, accanto a personaggi, animali e oggetti mitici o cultuali, sono riprodotti carri, arredamenti, vesti e drappi, suppellettili di uso e di cosmesi, e scene musicali e di danza.
Il soggetto figurativo prevalente nell’intero corpus, costituito da 5360 pinakes, è legato al grande ciclo mitologico della vita di Persephone. Le immagini illustrano il racconto del passaggio di Kore in Persephone, dal suo rapimento da parte di Hades, quando ancora vergine mortale, coglieva fiori sul prato, all’arrivo nel mondo sotterraneo, sino alla preparazione delle nozze e alla festa della presentazione dei doni da parte delle varie divinità alla dea seduta sul trono, sposa di Hades e già sovrana nel regno degli Inferi.
Le raffigurazioni dei pinakes sarebbero espressione e concorderebbero con il culto della dea, nella sua duplice qualità di divinità ctonia e di protettrice della fertilità umana, praticato nel santuario della Mannella e dei riti a lei collegati durante i quali, presumibilmente prima delle nozze, le fanciulle dedicavano alla dea le tavolette votive con scene della vita di Persephone, forse considerata metafora di quella delle giovani donne.
Nel complesso ideologico dei pinakes di Locri, la musica sembra avere avuto un ruolo nei riti di passaggio dall’adolescenza all’età adulta nell’ambito di una religiosità fortemente legata alla vita sociale.
Le raffigurazioni musicali nella coroplastica della Sicilia greca (VI-III sec. a.C.)
Creators: name: Bellia, Angela
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2011
Subjects: L-ART/07 Musicologia e storia della musica
L-ANT/07 Archeologia classica

description: Nell’ambito degli studi archeologici, le ricerche hanno ampiamente trattato aspetti musicali dell’antichità attraverso l’iconografia delle ceramiche attiche e greche in generale. Manca da questa documentazione un’analoga trattazione della coroplastica con raffigurazioni musicali del mondo greco. Con questo progetto di ricerca si è inteso avviare l’elaborazione di corpora comprendenti lo studio di questo repertorio da organizzare per regioni, a partire dalla Sicilia.
Sono stati individuati trentacinque siti di rinvenimento di statuette di suonatori, più frequentemente di suonatrici, singole o in gruppo, di aulos, tympanon, kymbala, kithara, arpa presso le aree sacre urbane ed extraurbane, gli abitati e le necropoli.
La classificazione ha consentito di prendere in considerazione un insieme omogeneo di statuette legate dalla presenza del medesimo strumento musicale e, nell’aspetto formale, da analoghe caratteristiche riconducibili ad un modello comune e di individuare i maggiori centri di produzione di statuette con raffigurazioni musicali in Sicilia, la diffusione di analoghe figurine nella Magna Graecia e nel Mediterraneo di età greca.
L’analisi dei contesti di rinvenimento ha permesso di determinare la ricorrenza delle associazioni e, nello stesso tempo, là dove possibile, un approccio al significato dell’ “offerta musicale” e alla eventuale relazione con i culti e i riti connessi agli specifici contesti votivi.
Le raffigurazioni musicali nei Cippi funerari della Collezione Casuccini del Museo Archeologico Regionale "A. Salinas" di Palermo
Creators: name: Bellia, Angela
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2010
Subjects: L-ART/07 Musicologia e storia della musica
L-ANT/06 Etruscologia e antichità italiche

description: Il Museo Archeologico Regionale di Palermo custodisce, da oltre un secolo, la più bella e notevole raccolta di antichità chiusine fuori dalla Toscana: la Collezione Casuccini. In essa, che comprende circa diecimila reperti tra interi e frammentari, vi sono i cippi funerari con decorazione a rilievo, di cui generalmente si conserva la parte a forma di dado che conteneva le ceneri del defunto.  
I temi figurativi presenti sulle quattro facce fanno parte del repertorio iconografico etrusco di età arcaica con valenza funeraria e con richiamo alla vita del defunto e al rituale funebre. Ricorrenti sono le scene musicali legate al banchetto o al simposio, forse parte integrante della cerimonia funebre. Le immagini sono una manifestazione significativa e il riflesso dell’ideologia aristocratica e del sistema di vita della società chiusina. Le raffigurazioni sembrerebbero rievocare il rito che doveva svolgersi vicino alla sepoltura, probabilmente impegnando gli stessi parenti del defunto in esecuzioni di danza accompagnata da strumenti musicali, in particolare l’aulos e la kithara.
Kurzkettige Dehydrogenasen/Reduktasen aus Pflanzen - anwendungsbezogene Untersuchungen zu Cosubstratpräferenz und Reduktion bizyklischer Diketone
Creators: name: Schläger, Sabrina
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2017
Subjects: subject: 572

description: Für die Wirkstoffsynthese ist es aufgrund der komplexen Strukturen und dem hohen Reinheitsanspruch wichtig, effiziente und hochselektive Syntheserouten zu entwickeln. Um dieses Ziel zu erreichen, werden seit einigen Jahren Enzyme als Biokatalysatoren eingesetzt. Die beiden pflanzlichen, kurzkettigen Dehydrogenasen/Reduktasen At2g29350 und CoTR zeigten in vorherigen Arbeiten vielversprechende katalytische Eigenschaften. Die Ziele dieser Arbeit waren, die Cosubstratpräferenz der beiden NADPH-abhängigen Enzyme hin zu dem kostengünstigeren Cosubstrat NADH zu optimieren und die katalytischen Eigenschaften hinsichtlich der Reduktion des Wieland-Miescher- und Hajos-Parrish-Ketons zu testen. Beide bizyklischen Diketone sind wichtige Bausteine in der Wirkstoffsynthese. Die Cosubstratpräferenz wurde durch die Einführung von zwei Mutationen optimiert. At2g29350 zeigte eine stereospezifische Reduktion der (S)-Enantiomere der Diketone und CoTR eine stereoselektive Reduktion der (R)-Enantiomere.
description: Complex structures and the requirement of high purity for active pharmaceutical compounds demand the synthesis to be efficient and specific. To achieve this target, enzymes have been used as biocatalysts for several years. The two plant-derived, short-chain dehydrogenases/reductases At2g29350 and CoTR showed promising catalytic abilities in previous works. The aim of this thesis was the optimization of the cosubstrate preference of these NADPH-depending enzymes towards the more affordable cosubstrate NADH. Additionally, the catalytic potential of both enzymes was investigated by testing the stereoselective reduction of Wieland-Miescher and Hajos-Parrish ketone. Both bicyclic diketones are important building blocks in the synthesis of active compounds. Cosubstrate preference was optimized by inserting two mutations. At2g29350 showed a stereospecific reduction of the (S)-enantiomers of both diketones and CoTR a stereoselective reduction of both (R)-enantiomers.
Additional file 1 of Effect of epigallocatechin gallate on dental biofilm of Streptococcus mutans: An in vitro study
Creators: name: Schneider-Rayman, Mor
name: Steinberg, Doron
name: Sionov, Ronit Vogt
name: Friedman, Michael
name: Shalish, Miriam
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1. Table 1: The primers used for real-time PCR.
At the "Crossroads” : the interaction between speech rhythm and musical rhythm in Tom Waits's spoken-word song
Creators: name: Lemire, Chantal
Publisher: name: University of British Columbia
Year: 2013

description: In this study I will analyze the spoken-word song, “Crossroads,” by singer-songwriter Tom Waits. “Crossroads” combines natural speech and metrical music, which highlights the rhythmic similarities and differences between speech and music. My analysis combines analytical tools developed in linguistics and music that can examine the rhythmic sensations created through spoken word. Christopher Hasty’s theory of metric projection represents the rhythmic structure of the musical accompaniment, and Bruce Hayes’s theory of metrical stress represents the rhythmic structure of Waits’s speech. The combination of the two theories explores how the presence of natural speech changes my sensation of the musical accompaniment, and vice versa. In my analysis of “Crossroads,” I propose that combination of speech and metrical music can generate a unique sensation of rhythm and structure akin to an optical illusion. This approach offers one possible way that the analysis of spoken word can prioritize its performance aspects to the same degree as the artists who use the form.
Electronic entanglement in late transition metal oxides
Creators: name: Thunström, Patrik
name: Di Marco, Igor
name: Eriksson, Olle
Publisher: name: arXiv
Year: 2012
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Here we present a study of the entanglement in the electronic structure of the late transition metal monoxides - MnO, FeO, CoO, and NiO - obtained by means of density-functional theory in the local density approximation combined with dynamical mean-field theory (LDA+DMFT). The impurity problem is solved through Exact Diagonalization (ED), which grants full access to the thermally mixed many-body ground state density operator. The quality of the electronic structure is affirmed through a direct comparison between the calculated electronic excitation spectrum and photoemission experiments. Our treatment allows for a quantitative investigation of the entanglement in the electronic structure. Two main sources of entanglement are explicitly resolved through the use of a fidelity based geometrical entanglement measure, and additional information is gained from a complementary entropic entanglement measure. We show that the interplay of crystal field effects and Coulomb interaction causes the entanglement in CoO to take a particularly intricate form.
description: Minor changes. Journal reference added
Wirkmechanismen der Interaktion mesenchymaler Stammzellen und Karzinom-assoziierter Fibroblasten mit Brustkrebszellen
Creators: name: Leyh, Benjamin
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2019
Subjects: subject: stromale Zellen; Anti-Estrogen-Resistenz; Fulvestrant; mesenchymale Stammzellen; Tumor-assoziierte Fibroblasten; IGFBP5; Bcl-3
subject: stromal cells; anti-estrogen resistance; fulvestrant; mesenchymal stem cells; carcinoma-associated fibroblasts; IGFBP5; Bcl-3
subject: 572

description: In dieser Arbeit konnte gezeigt werden, dass mesenchymale Stammzellen (MSC) und Karzinom-assoziierte Fibroblasten (CAF) einen desensibilisierenden Effekt gegen das Anti-Estrogen Fulvestrant in ERα-positiven Brustkrebszellen induzieren. MSCs und CAFs steigerten in MCF-7-Zellen die Aktivitäten des Phosphoinositid-3-Kinase (PI3K)/AKT- Signalweges und erhöhten die Proteinexpressionen von Integrin β1, insulin-like growth factor 1 receptor (IGF1R), hypoxia-inducible factor 1-α (HIF1α), Carboanhydrase IX (CAIX) und B-cell lymphoma 3-encoded protein (Bcl-3). Weiterführende Analysen konnten zeigen, dass diese Induktionen sowie die Therapieresistenz durch eine MSC- und CAF-vermittelte parakrine Herunterregulation des IGF binding protein 5 (IGFBP5) und der Erhöhung von Bcl-3 in den MCF-7-Zellen verursacht wurde. In silico-Analysen endokrin therapierter Patientinnen zeigten, dass eine erhöhte Expression von Bcl-3 sowie eine verminderte Expression seiner Zielgene KLHL4 und SEPP1 mit einer schlechteren Prognose assoziiert sind. Des Weiteren konnte Interleukin-6 (IL6) als möglicher parakriner Faktor der stromalen Zellen identifiziert werden.
description: In this work it could be shown that mesenchymal stem cells (MSC) and carcinoma-associated fibroblasts (CAF) induce a desensitizing effect against the anti-estrogen fulvestrant in ERα-positive breast cancer cells. MSCs and CAFs increased the activities of the phosphoinositide 3-kinase (PI3K)/AKT signaling pathway in MCF-7 cells and increased protein expression of integrin β1, insulin-like growth factor 1 receptor (IGF1R), hypoxia-inducible factor 1 α (HIF1α), carbonic anhydrase IX (CAIX) and B-cell lymphoma 3-encoded protein (Bcl-3). Further analysis showed that these induction as well as treatment resistance were caused by MSC- and CAF-mediated paracrine downregulation of IGF binding protein 5 (IGFBP5) and increase of Bcl-3 in the MCF-7 cells. In-silico analyses of endocrine-treated patients showed that increased expression of Bcl-3 as well as reduced expression of its target genes KLHL4 and SEPP1 are associated with a poorer prognosis. Furthermore, interleukin-6 (IL6) could be identified as a potential paracrine factor of stromal cells.
Additional file 1 of Association of Lipoprotein (a) variants with risk of cardiovascular disease: a Mendelian randomization study
Creators: name: Xia, Juan
name: Guo, Chunyue
name: Liu, Kuo
name: Xie, Yunyi
name: Cao, Han
name: Peng, Wenjuan
name: Sun, Yanyan
name: Liu, Xiaohui
name: Li, Bingxiao
name: Zhang, Ling
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Additional file 1: Table S1. Genetic association of Lp(a) level related 13 genetic variants with cardiovascular disease subtypes. Table S2. MR base single SNP. Figure 1–1. MR leave-one-out sensitivity analysis for Lp(a) on Congestive Heart Failure. Figure 1–2. MR leave-one-out sensitivity analysis for Lp(a) on Ischemic Stroke. Figure 1–3. MR leave-one-out sensitivity analysis for Lp(a) on Atrial Fibrillation. Figure 1–4. MR leave-one-out sensitivity analysis for Lp(a) on Arrhythmia. Figure 1–5. MR leave-one-out sensitivity analysis for Lp(a) on Left Ventricular Mass Index. Figure 1–6. MR leave-one-out sensitivity analysis for Lp(a) on Left Ventricular Internal Dimension in Diastole. Figure 1–7. MR leave-one-out sensitivity analysis for Lp(a) on Left Ventricular Internal Dimension in Systole. Figure 2–1. Single SNP analysis for Lp(a) on Congestive Heart Failure. Figure 2–2. Single SNP analysis for Lp(a) on Ischemic Stroke. Figure 2–3. Single SNP analysis for Lp(a) on Atrial Fibrillation. Figure 2–4. Single SNP analysis for Lp(a) on Arrhythmia. Figure 2–5. Single SNP analysis for Lp(a) on Left Ventricular Mass Index. Figure 2–6. Single SNP analysis for Lp(a) on Left Ventricular Internal Dimension in Diastole. Figure 2–7. Single SNP analysis for Lp(a) on Left Ventricular Internal Dimension in Systole