cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Vorausschau für den Klimaschutz: mobile Arbeit in der Zukunft
Creators: name: Kimpeler, Simone
name: Erdmann, Lorenz
Publisher: name: Umweltbundesamt
Year: 2023
Subjects: subject: Futurologie
subject: Trendanalyse
subject: Telearbeit
subject: Klimaschutz
subject: Mobilitätsverhalten
subject: Konsum
subject: Nachhaltiger Konsum
subject: Suburbanisierung
subject: Digitalisierung
subject: Zukunftsforschung
subject: Foresight
subject: Trend
subject: Mobile Arbeit
subject: Nachhaltigkeit | Strategien | Internationales

description: Künftig werden wohl immer mehr Menschen nicht mehr im Büro am Standort des Unternehmens oder der öffentlichen Einrichtung, sondern im Homeoffice, auf Dienstreisen oder in Coworking-Räumen arbeiten. Wie sieht die Mobile Arbeitswelt in der Zukunft aus? Was geschieht mit den klassischen Büroräumen? Wie verändern sich die privaten Räume? Wo siedeln sich künftig die Menschen an? Welche Konsumangebote und Dienstleistungen wird es wo geben?. Die vorliegende Broschüre aus der Reihe "Vorausschau für den Klimaschutz" untersucht, welche Trends die Mobile Arbeit in Zukunft verändern werden, wie sich das auf den Klimaschutz auswirken kann und welche Gestaltungsmöglichkeiten sich für die Klimaschutzpolitik ergeben. "Mobile Arbeit in der Zukunft" ist ein Ergebnis des Vorhabens "Strategische Früherkennung (Horizon Scanning) klimaschutzrelevanter Entwicklungen" mit dem das Bundesministerium für Wirtschaft und Klimaschutz zusammen mit dem Umweltbundesamt die Maßnahme 3.5.4.3 des 2019 beschlossenen Klimaschutzprogramms 2030 umsetzt. Quelle: www.umweltbundesamt.de
description: Künftig werden wohl immer mehr Menschen nicht mehr im Büro am Standort des Unternehmens oder der öffentlichen Einrichtung, sondern im Homeoffice, auf Dienstreisen oder in Coworking-Räumen arbeiten. Wie sieht die Mobile Arbeitswelt in der Zukunft aus? Was geschieht mit den klassischen Büroräumen? Wie verändern sich die privaten Räume? Wo siedeln sich künftig die Menschen an? Welche Konsumangebote und Dienstleistungen wird es wo geben?.Die vorliegende Broschüre aus der Reihe „Vorausschau für den Klimaschutz“ untersucht, welche Trends die Mobile Arbeit in Zukunft verändern werden, wie sich das auf den ⁠Klimaschutz⁠ auswirken kann und welche Gestaltungsmöglichkeiten sich für die Klimaschutzpolitik ergeben.„Mobile Arbeit in der Zukunft“ ist ein Ergebnis des Vorhabens „Strategische Früherkennung (Horizon Scanning) klimaschutzrelevanter Entwicklungen“ mit dem das Bundesministerium für Wirtschaft und Klimaschutz zusammen mit dem Umweltbundesamt die Maßnahme 3.5.4.3 des 2019 beschlossenen Klimaschutzprogramms 2030 umsetzt.
Early introduction of foods to prevent food allergy
Creators: name: Chan, Edmond S.
name: Abrams, Elissa M.
name: Hildebrand, Kyla J.
name: Watson, Wade
Publisher: name: BioMed Central
Year: 2018

description: Food allergy is a growing public health problem, and in many affected individuals, the food allergy begins early in life and persists as a lifelong condition (e.g., peanut allergy). Although early clinical practice guidelines recommended delaying the introduction of peanut and other allergenic foods in children, this may have in fact contributed to the dramatic increase in the prevalence of food allergy in recent decades. In January 2017, new guidelines on peanut allergy prevention were released which represented a significant paradigm shift in early food introduction. Development of these guidelines was prompted by findings from the Learning Early About Peanut Allergy study—the first randomized trial to investigate early allergen introduction as a strategy to prevent peanut allergy. This article will review and compare the new guidelines with previous guidelines on food introduction, and will also review recent evidence that has led to the paradigm shift in early food introduction.
Effect of Local Environment and Stellar Mass on Galaxy Quenching and Morphology at 0.5 z 2.0
Creators: name: Kawinwanichakij, Lalitwadee
name: Papovich, Casey
name: Quadri, Ryan F.
name: Glazebrook, Karl
name: Kacprzak, Glenn
name: Allen, Rebecca
name: Bell, Eric F.
name: Croton, Darren
name: Dekel, Avishai
name: Ferguson, Henry C.
name: Forrest, Ben
name: Grogin, Norman A.
name: Guo, Yicheng
name: Kocevski, Dale D.
name: Koekemoer, Anton M.
name: Labbe, Ivo
name: Lucas, Ray A.
name: Nanayakkara, Themiya
name: Spitler, Lee R.
name: Straatman, Caroline M.S.
name: Tran, Kim Vy H.
name: Tomczak, Adam
name: Dokkum, Pieter Van
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 510103
subject: Cosmology and extragalactic astronomy

description: We study galactic star formation activity as a function of environment and stellar mass over 0.5 < z < 2.0 using the FourStar Galaxy Evolution (ZFOURGE) survey. We estimate the galaxy environment using a Bayesian-motivated measure of the distance to the third nearest neighbor for galaxies to the stellar mass completeness of our survey, log(M / M-circle dot)> 9(9.5) at z = 1.3 (2.0). This method, when applied to a mock catalog with the photometric-redshift precision (sigma(z) (1+ z) less than or similar to 0.02) of ZFOURGE, accurately recovers galaxies in low-and high-density environments. We quantify the environmental quenching efficiency and show that at z > 0.5, it depends on galaxy stellar mass, demonstrating that the effects of quenching related to (stellar) mass and environment are not separable. In high-density environments, the mass and environmental quenching efficiencies are comparable for massive galaxies (log(M / M-circle dot) greater than or similar to 10.5) at all redshifts. For lower-mass galaxies (log(M / M)(circle dot)) less than or similar to 10), the environmental quenching efficiency is very low at z greater than or similar to 1.5, but increases rapidly with decreasing redshift. Environmental quenching can account for nearly all quiescent lower-mass galaxies (log(M / M-circle dot) similar to 9-10), which appear primarily at z less than or similar to 1.0. The morphologies of lower-mass quiescent galaxies are inconsistent with those expected of recently quenched star-forming galaxies. Some environmental process must transform the morphologies on similar timescales as the environmental quenching itself. The evolution of the environmental quenching favors models that combine gas starvation (as galaxies become satellites) with gas exhaustion through star formation and outflows ("overconsumption"), and additional processes such as galaxy interactions, tidal stripping, and disk fading to account for the morphological differences between the quiescent and star-forming galaxy populations.
Option B+ for prevention of vertical HIV transmission has no influence on adverse birth outcomes in a cross-sectional cohort in Western Uganda
Creators: name: Rempis, Eva M.
name: Schnack, Alexandra
name: Decker, Sarah
name: Braun, Vera
name: Rubaihayo, John
name: Tumwesigye, Nazarius Mbona
name: Busingye, Priscilla
name: Harms, Gundel
name: Theuring, Stefanie
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Human immunodeficiency virus type 1 (HIV-1)
subject: Antiretroviral therapy (ART)
subject: Prevention of mother-to-child-transmission (PMTCT)
subject: Option B+
subject: Adverse pregnancy (birth) outcomes
subject: Stillbirth
subject: Preterm delivery
subject: Small for gestational age
subject: Uganda
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background While most Sub-Saharan African countries are now implementing the WHO-recommended Option B+ protocol for prevention of vertical HIV transmission, there is a lack of knowledge regarding the influence of Option B+ exposure on adverse birth outcomes (ABOs). Against this background, we assessed ABOs among delivering women in Western Uganda. Methods A cross- sectional, observational study was performed within a cohort of 412 mother- newborn-pairs in Virika Hospital, Fort Portal in 2013. The occurrence of stillbirth, pre-term delivery, and small size for gestational age (SGA) was analysed, looking for influencing factors related to HIV-status, antiretroviral drug exposure and duration, and other sociodemographic and clinical parameters. Results Among 302 HIV-negative and 110 HIV-positive women, ABOs occurred in 40.5%, with stillbirth in 6.3%, pre-term delivery in 28.6%, and SGA in 12.2% of deliveries. For Option B+ intake (n = 59), no significant association was found with stillbirth (OR 0.48, p = 0.55), pre- term delivery (OR 0.97, p = 0.92) and SGA (OR 1.5, p = 0.3) compared to seronegative women. Women enrolled on antiretroviral therapy (ART) before conception (n = 38) had no different risk for ABOs than women on Option B+ or HIV-negative women. Identified risk factors for stillbirth included lack of formal education, poor socio-economic status, long travel distance, hypertension and anaemia. Pre-term delivery risk was increased with poor socio-economic status, primiparity, Malaria and anaemia. The occurrence of SGA was influenced by older age and Malaria. Conclusion In our study, women on Option B+ showed no difference in ABOs compared to HIV-negative women and to women on ART. We identified several non-HIV/ART-related influencing factors, suggesting an urgent need for improving early risk assessment mechanisms in antenatal care through better screening and triage systems. Our results are encouraging with regard to continued universal scale-up of Option B+ and ART programmes.
title: Lesiones del ligamento cruzado posterior: descripción de los hallazgos en RM y correlación artroscópica.
Creators: name: Baeva, Maria
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Musculoskeletal soft tissue
subject: MR
subject: Athletic injuries

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
OBJETIVOS Describir la apariencia en resonancia magnética (RM) de las lesiones del ligamento cruzado posterior (LCP) comprobadas mediante artroscopia,
con especial énfasis en los distintos planos (sagitales,
axiales y coronales) en secuencias...
title: Hallazgos en las técnicas de imagen de la neumonía organizada: Revisión de nuestra experiencia
Creators: name: Garcia Carballo, Marta
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Thorax
subject: CT-High Resolution
subject: PET-CT

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
A partir de los 31 casos de NO diagnosticados en el Hospital Clínico Universitario San Carlos de Madrid,
durante los años 2000-2011,
se realiza una revisión de esta patología con el fin de: Repasar las características clínicas e...
Focal Cortical Lesions Induce Bidirectional Changes in the Excitability of Fast Spiking and Non Fast Spiking Cortical Interneurons
Creators: name: Imbrosci, Barbara
name: Neitz, Angela
name: Mittmann, Thomas
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: A physiological brain function requires neuronal networks to operate within a well-defined range of activity. Indeed, alterations in neuronal excitability have been associated with several pathological conditions, ranging from epilepsy to neuropsychiatric disorders. Changes in inhibitory transmission are known to play a key role in the development of hyperexcitability. However it is largely unknown whether specific interneuronal subpopulations contribute differentially to such pathological condition. In the present study we investigated functional alterations of inhibitory interneurons embedded in a hyperexcitable cortical circuit at the border of chronically induced focal lesions in mouse visual cortex. Interestingly, we found opposite alterations in the excitability of non fast-spiking (Non Fs) and fast-spiking (Fs) interneurons in acute cortical slices from injured animals. Non Fs interneurons displayed a depolarized membrane potential and a higher frequency of spontaneous excitatory postsynaptic currents (sEPSCs). In contrast, Fs interneurons showed a reduced sEPSCs amplitude. The observed downscaling of excitatory synapses targeting Fs interneurons may prevent the recruitment of this specific population of interneurons to the hyperexcitable network. This mechanism is likely to seriously affect neuronal network function and to exacerbate hyperexcitability but it may be important to protect this particular vulnerable population of GABAegic neurons from excitotoxicity.
Psychological experiences of mothers following a diagnosis of cancer
Creators: name: Kuswanto, Carissa Nadia
Publisher: name: Swinburne
Year: 2024

description: The research aims to explore mothers' psychological experiences and challenges after being diagnosed with breast cancer. Using Bury's biographical disruption framework, which postulates that chronic illness disrupts one's physical self, identity/role and life trajectory, the thesis presents the first study that investigates how biographical disruption predicts psychological distress, and elucidates the relationships between biographical disruption, self-compassion, posttraumatic growth and psychological distress in mothers who are breast cancer survivors. The research findings highlight the important role of healthcare professionals in addressing psychological distress and parenting concerns, and providing effective and appropriate psychosocial support for mothers who are breast cancer survivors.
The Emerson Siphon Theory: A Complete Unification of Field Theory via Inherited Motion
Creators: name: Emerson, Alec Chad
Publisher: name: Zenodo
Year: 2025
Subjects: subject: Gravity
subject: Theoretical physics
subject: Quantum physics
subject: Black holes
subject: Big bang

description: This paper presents The Emerson Siphon Theory — a novel cosmological framework that redefines gravity, mass, and universal emergence as consequences of directional kinetic flow. Unlike traditional models that treat gravity as curvature or force-at-a-distance, this theory proposes a siphon-like mechanism wherein particles are ejected from singularities under extreme compression, creating a kinetic memory corridor that binds subsequent particles into structured matter and spacetime. This directional emergence preserves information, unifies quantum entanglement with gravitational behavior, and offers a predictive explanation for phenomena like black hole collapse, gamma ray bursts, and apparent dark matter effects without invoking patchwork fixes. It challenges the foundations of current cosmology and proposes a new paradigm where the universe is not born in chaos, but ordered through directional flow — a siphon, not a bang.
Inter-relations of orthostatic blood pressure change, aortic stiffness, and brain structure and function in young adults
Creators: name: Cooper, Leroy L.
name: Himali, Jayandra J.
name: Torjesen, Alyssa
name: Tsao, Connie W.
name: Beiser, Alexa
name: Hamburg, Naomi M.
name: DeCarli, Charles
name: Vasan, Ramachandran S.
name: Seshadri, Sudha
name: Pase, Matthew
name: Mitchell, Gary F.
Publisher: name: Swinburne
Year: 2024

description: Background--Relations of orthostatic change in blood pressure with brain structure and function have not been studied thoroughly, particularly in younger, healthier individuals. Elucidation of factors that contribute to early changes in brain integrity may lead to development of interventions that delay or prevent cognitive impairment. Methods and Results--In a sample of the Framingham Heart Study Third Generation (N=2119; 53% women; mean age±SD, 47±8 years), we assessed orthostatic change in mean arterial pressure (MAP), aortic stiffness (carotid-femoral pulse wave velocity), neuropsychological function, and markers of subclinical brain injury on magnetic resonance imaging. Multivariable regression analyses were used to assess relations between orthostatic change in MAP and brain structural and neuropsychological outcomes. Greater orthostatic increase in MAP on standing was related to better Trails B-A performance among participants aged < 49 years (β±SE, 0.062±0.029; P=0.031) and among participants with carotid-femoral pulse wave velocity < 6.9 m/s (β±SE, 0.063±0.026; P=0.016). This relation was not significant among participants who were older or had stiffer aortas. Conversely, greater orthostatic increase in MAP was related to larger total brain volume among older participants (β±SE, 0.065±0.029; P=0.023) and among participants with carotid-femoral pulse wave velocity ≥6.9 m/s (β±SE, 0.078±0.031; P=0.011). Conclusions--Blunted orthostatic increase in MAP was associated with smaller brain volume among participants who were older or had stiffer aortas and with poorer executive function among persons who were younger or who had more-elastic aortas. Our findings suggest that the brain is sensitive to orthostatic change in MAP, with results dependent on age and aortic stiffness.
title: Antropometría del LCA
Creators: name: Diez Renovales, Fernando
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: MR
subject: Musculoskeletal soft tissue
subject: Extremities

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
Los ligamentos cruzados de la rodilla reproducen,
en visión lateral,
un dispositivo mecánico de cuatro barras cruzadas.
Se insertan,
tanto en el fémur como en la tibia a una distancia uno del otro no cuantificada. Fig. 1 Fig. 2 Tras su...
Quebec City's Ship Carpenters, 1840 to 1893: Working Class Self-Organization on the Waterfront
Creators: name: Mathieu, Jean-Philip
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: History, Canadian.

description: In the mid-nineteenth century, the construction of wooden sailing vessels became the single most important employer in Quebec City. Thousands of people worked as shipwrights in the shipbuilding industry, but ship carpenters were the backbone of the trade. These workers displayed an extraordinary capacity for mobilization, being responsible for some of Canada's earliest labour organizations, starting in 1840 with the Societe amicale et bienveillante des charpentiers de vaisseaux de Quebec. This study demonstrates that ship carpenters' impressive capacity for organization was the result of the trade's remarkable ethnic homogeneity, as no less than 90% of ship carpenters were French Canadian, and most lived together in the working class suburb of Saint Roch. This homogeneity allowed ship carpenters to avoid the bitter internecine conflict that plagued the early labour movement, and allowed them to become part of the vanguard of the Canadian working class.
Leitfaden zur umweltfreundlichen öffentlichen Beschaffung: Windeln, Damenhygiene- und Inkontinenzprodukte (Absorbierende Hygieneprodukte)
Creators: name: (:Unkn) Unknown
Publisher: name: Umweltbundesamt
Year: 2022
Subjects: subject: Öffentliche Beschaffung
subject: Umweltfreundliche Beschaffung
subject: Windeln
subject: Einwegwindeln
subject: Babywindeln
subject: Inkontinenzprodukte
subject: Damenhygieneprodukte
subject: Wirtschaft | Konsum

description: Beim Tragen von absorbierenden Hygieneprodukten besteht ständig Hautkontakt mit diesen Produkten, sodass auch kleinste Mengen an gesundheitsschädlichen Chemikalien negative Auswirkungen haben können. Für die in den Produkten enthaltenen Materialien enthält der Leitfaden daher strenge Anforderungen und eine detaillierte Ausschlussliste an Schadstoffen und gesundheitsschädlichen Substanzen. Um das Risiko für Allergien zu vermindern, wird empfohlen, den Einsatz von Lotionen und Duftstoffen zu untersagen. Weitere Schwerpunkte liegen auf der Herkunft und Herstellung des Zellstoffs. Dieser Leitfaden basiert auf den Kriterien des Umweltzeichens Blauer Engel Windeln, Damenhygiene- und Inkontinenzprodukte (DE-UZ 208, Ausgabe Januar 2021). Quelle: www.umweltbundesamt.de
description: Beim Tragen von absorbierenden Hygieneprodukten besteht ständig Hautkontakt mit diesen Produkten, sodass auch kleinste Mengen an gesundheitsschädlichen Chemikalien negative Auswirkungen haben können.Für die in den Produkten enthaltenen Materialien enthält der Leitfaden daher strenge Anforderungen und eine detaillierte Ausschlussliste an Schadstoffen und gesundheitsschädlichen Substanzen. Um das Risiko für Allergien zu vermindern, wird empfohlen, den Einsatz von Lotionen und Duftstoffen zu untersagen. Weitere Schwerpunkte liegen auf der Herkunft und Herstellung des Zellstoffs.Dieser Leitfaden basiert auf den Kriterien des Umweltzeichens Blauer Engel Windeln, Damenhygiene- und Inkontinenzprodukte (DE-UZ 208, Ausgabe Januar 2021).
Strategic solutions to overcome emerging public health challenges with emphasis on vector-borne diseases (VBDs)
Creators: name: Ahmadi Marzaleh, Milad
name: Hamyali Ainvand, Marziyeh
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2024
Subjects: emerging challenges
global public health
vector-borne diseases
emergence diseases
climate change
disasters
emergencies

description: EXCLI Journal; 23:Doc1353; ISSN 1611-2156
Supplementary document for Modified optical response of biased semiconductor nanowires within nonlocal hydrodynamic framework - 4702116.pdf
Creators: name: Dong, Tianyu
name: Gao, Xiaoke
name: Yin, Ke
name: Xu, Chun
name: Ma, Xikui
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Additional equations not listed in the main text.
Creatine supplementation post-exercise does not enhance training-induced adaptations in middle to older aged males
Creators: name: Cooke, Matthew
name: Brabham, Brian
name: Buford, Thomas W.
name: Shelmadine, Brian D.
name: McPheeters, Matthew
name: Hudson, Geoffrey M.
name: Stathis, Christos
name: Greenwood, Mike
name: Kreider, Richard
name: Willoughby, Darryn S.
Publisher: name: Swinburne
Year: 2024

description: Purpose: The present study evaluated the effects of creatine monohydrate (CrM) consumption post-exercise on body composition and muscle strength in middle to older males following a 12-week resistance training program. Methods: In a double-blind, randomized trial, 20 males aged between 55 and 70 years were randomly assigned to consume either CrM-carbohydrate (CHO) [20 g days -1 CrM + 5 g days-1 CHO × 7 days, then 0.1 g kg -1 CrM + 5 g CHO on training days (average dosage of ∼8.8 g)] or placebo CHO (20 g days-1 CHO × 7 days, then 5 g CHO on training days) while participating in a high intensity resistance training program [3 sets × 10 repetitions at 75 % of 1 repetition maximum (1RM)], 3 days weeks-1 for 12 weeks. Following the initial 7-day "loading" phase, participants were instructed to ingest their supplement within 60 min post-exercise. Body composition and muscle strength measurements, blood collection and vastus lateralis muscle biopsy were completed at 0, 4, 8 and 12 weeks of the supplement and resistance training program. Results: A significant time effect was observed for 1RM bench press (p = 0.016), leg press (p = 0.012), body mass (p = 0.03), fat-free mass (p = 0.005) and total myofibrillar protein (p = 0.005). A trend for larger muscle fiber cross-sectional area in the type II fibers compared to type I fibers was observed following the 12-week resistance training (p = 0.08). No supplement interaction effects were observed. Conclusion: Post-exercise ingestion of creatine monohydrate does not provide greater enhancement of body composition and muscle strength compared to resistance training alone in middle to older males. © 2014 The Author(s).
Effect of interferon beta-1a subcutaneously three times weekly on clinical and radiological measures and no evidence of disease activity status in patients with relapsing–remitting multiple sclerosis at year 1
Creators: name: Traboulsee, Anthony
name: Li, David K. B.
name: Cascione, Mark
name: Fang, Juanzhi
name: Dangond, Fernando
name: Miller, Aaron
Publisher: name: BioMed Central
Year: 2018

description: Background: In the PRISMS study, interferon beta-1a subcutaneously (IFN β-1a SC) reduced clinical and radiological disease burden at 2 years in patients with relapsing–remitting multiple sclerosis. The study aimed to characterize efficacy of IFN β-1a SC 44 μg and 22 μg three times weekly (tiw) at Year 1. Methods: Exploratory endpoints included annualized relapse rate (ARR), 3-month confirmed disability progression (1-point Expanded Disability Status Scale increase if baseline was < 6.0 [0.5-point if baseline was ≥6.0]), active T2 lesions, and no evidence of disease activity (NEDA; defined as no relapses [subanalyzed by relapse severity], 3-month confirmed progression, or active T2 lesions). Effect of IFN β-1a SC in prespecified patient subgroups was also assessed. Results: Patients were randomized to IFN β-1a 22 μg (n = 189), 44 μg (n = 184), or placebo (n = 187). At 1 year, IFN β-1a SC tiw reduced ARR (p < 0.001), risk of disability progression (p ≤ 0.029), and mean number of active T2 lesions per patients per scan (p < 0.001) versus placebo. Clinical and radiological benefits were seen as early as Month 2 and 3. Outcomes in subgroups were consistent with those in the overall population. More patients treated with IFN β-1a SC tiw achieved NEDA status, versus placebo, regardless of relapse severity (p ≤ 0.006). Conclusion: Clinical, radiological, and NEDA outcomes at Year 1 were consistent with Year 2 results. Treatment efficacy was consistent in pre-specified patient subgroups.
The Historic Dark Ride: Reimagined for Virtual Experience
Creators: name: Zika, Joel
Publisher: name: Swinburne
Year: 2024

description: The outcome of this research project is the creation of a contemporary ‘dark ride’. Dark rides are a type of amusement park entertainment that originated in the early 20th century and are still built today; including the ever popular Ghost Train and Haunted Mansion rides. Although the dark ride is a well-known aspect of popular culture, study of its history and impact on other media has been limited. This research examines what the characteristics of the early dark ride are and what influence it can provide for the creation of new entertainment experiences.
Sociocultural persuasion in advertising: Considerations for translators.
Creators: name: Cairns, Jill Kyla.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Business Administration, Marketing.

description: This thesis discusses how sociocultural meaning is layered into the rhetorical structure of advertising and illustrates how an ad's meaning achieves its goal of persuading consumers to buy a specific product. Its aim is to deepen translators' understanding of the advertising genre and elaborate a theoretical base that can help them make decisions about composing the translation specifically for the target culture. The key elements of translating advertising, namely the importance of its persuasive function, its cultural groundwork, and its communicative unity, are determined through a survey of translation literature. The recurrence of communicative variables such as the addresser-addressee relationship, intention, and purpose is furthered in an investigation of the rhetorical structure of print advertisements. A framework that describes the layering of ideologemes, values, and beliefs in persuasive language, through stereotypes and cliches, is proposed to improve translators' understanding of advertisements. This framework is then applied to four in-depth analyses of ads and their translations. Observations include translators' misunderstanding of the rhetorical importance of the textual and visual unity in ads and the importance of cliches as pivotal logical devices and carriers of sociocultural meaning.
Supplementary document for Modified optical response of biased semiconductor nanowires within nonlocal hydrodynamic framework - 4702116.pdf
Creators: name: Dong, Tianyu
name: Gao, Xiaoke
name: Yin, Ke
name: Xu, Chun
name: Ma, Xikui
Publisher: name: Optica Publishing Group
Year: 2020
Subjects: Uncategorized

description: Additional equations not listed in the main text.
Development of long-acting injectable suspensions by continuous antisolvent crystallization: An integrated bottom-up process
Creators: name: Nandi, Snehashis
name: Padrela, Luis
name: Tajber, Lidia
name: Collas, Alain
Publisher: name: University of Limerick
Year: 2024
Subjects: classificationCode: 34
subject: Chemical sciences
subject: FOS: Chemical sciences

description: Our present work elucidated the operational feasibility of direct generation and stabilization of long-acting injectable (LAI) suspensions of a practically insoluble drug, itraconazole (ITZ), by combining continuous liquid antisolvent crystallization with downstream processing (i.e., centrifugal filtration and reconstitution). A novel microchannel reactor-based bottom-up crystallization setup was assembled and optimized for the continuous production of micro-suspension. Based upon the solvent screening and solubility study, N-methyl pyrrolidone (NMP) was selected as the optimal solvent and an impinging jet Y-shaped microchannel reactor (MCR) was selected as the fluidic device to provide a reproducible homogenous mixing environment. Operating parameters such as solvent to antisolvent ratio (S/AS), total jet liquid flow rates (TFRs), ITZ feed solution concentration and the maturation time in spiral tubing were tailored to 1:9 v/v, 50 mL/min, 10 g/100 g solution, and 96 h, respectively. Vitamin E TPGS (0.5% w/w) was found to be the most suitable excipient to stabilize ITZ particles amongst 14 commonly used stabilizers screened. The effect of scaling up from 25 mL to 15 L was evaluated effectively with in situ monitoring of particle size distribution (PSD) and solid-state form. Thereafter, the suspension was subjected to centrifugal filtration to remove excess solvent and increase ITZ solid fraction. As an alternative, an even more concentrated wet pellet was reconstituted with an aqueous solution of 0.5% w/w Vitamin E TPGS as resuspending agent. The ITZ LAI suspension (of 300 mg/mL solid concentration) has the optimal PSD with a D10 of 1.1 ± 0.3 µm, a D50 of 3.53 ± 0.4 µm and a D90 of 6.5 ± 0.8 µm, corroborated by scanning electron microscopy (SEM), as remained stable after 548 days of storage at 25 ◦C. Finally, in vitro release methods using Dialyzer, dialysis membrane sac were investigated for evaluation of dissolution of ITZ LAI suspensions. The framework presented in this manuscript provides a useful guidance for development of LAI suspensions by an integrated bottom-up approach using ITZ as model API.
Business Intelligence & Analytics Adoption in Australian SMEs: Identified processes, decision-making, and leadership skills
Creators: name: Wee, Mak
Publisher: name: Swinburne
Year: 2024

description: This research provides an in-depth study of how Small and Medium Enterprises (SME) use Business Intelligence & Analytics(Bl&A) to derive business value and why many SMEs fail. Firstly, it provides an understanding of current decision-making practices in SMEs. Secondly, it suggests the use of a short simple six-step iterative Bl&A cycle and a long-termed three-phase process to derive insights for improved business process application. Lastly, the research proposes a Bl&A leadership skill framework that SME leaders can take concerning managing data, analytical skills, cultural change, and financial investment at each leadership level to attain greater business value.
The silver cross mother: A Canadian martyrology
Creators: name: Evans, Suzanne
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Religion, General.
subject: History, Canadian.

description: This dissertation compares the stories of mothers of martyrs from many different religious traditions with those of Canadian mothers who were willing to send their sons to war during World War One. Over the years in the Jewish, Christian, Islamic and Sikh traditions stories have been written, repeated, dramatized and painted of mothers who were supportive of their children's martyrdom. Between 1914 and 1918 the Canadian mothers of young men found themselves living in a world in which war was increasingly described in the religious language of sacrifice. This is evident from an examination of the newspapers, magazines, novels and poetry of the day as well as words from the politicians and the chaplains. It was within this environment and using these same media, that mothers were often depicted as offering the sacrifice of their sons for the cause of civilization, justice, truth and god. In Canada after the war the image of the proud, but mournful bereaved mother served to commemorate the battle and provide it with purpose and meaning in a world which had its belief systems shaken to the core. The images of mothers of martyrs and heroes from long ago, from World War One and from present times are all designed to have a lasting and powerful influence over public opinion, drawing supporters to the cause. This historical analysis shows how the poignant mother-child relationship has been used by leaders of states and religious communities in conflict situations as well as the mothers themselves to gain support for war. In all cases the key element in the role of the mother of the sacrificed is her acceptance of the neccessity to offer her child and for this she is compensated in a variety of ways including the receipt of the Memorial Cross, or as it is better known, the Silver Cross medal.
Zoomed paintings
Creators: name: Kreiner, Welf A.
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: Angle of view
subject: Angular scale
subject: DDC 530 / Physics
subject: Cornish, Vaughan <1862 - 1948>
subject: Visual perception
subject: Achenbach, Andreas
subject: Düsseldorf / Museum Kunst Palast
subject: Elsheimer, Adam
subject: Schönfeld, Johann Heinrich

description: When taking pictures with a camera, one usually zooms in or zooms out, depending on the situation, whether one is aiming for a narrow or wide field of view, respectively. The question is investigated whether zooming was, and still is, common practice to painters and drawers as well. It is shown that, on paintings and etchings, the angle of view can vary within a wide range, comparable to photos taken with a wide angle or a telephoto lens.
Feasibility of the bio-conversion of hydrocarbon feedstock to citric acid.
Creators: name: Crolla, Anna Maria.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Engineering, Chemical.

description: It is the focus of this study to examine the feasibility of using hydrocarbon oils as the sole source of carbon for the production of citric acid and biomass. Initial lab experiments were conducted using 1875 ml batch flask fermentations to determine the yeast strain of Candida lipolytica and hydrocarbon feedstock of choice. The two yeast strains investigated were Candida lipolytica NRRL-Y-1094 and Candida lipolytica NRRL-Y-1095. The two feedstocks evaluated were kerosene (Kero 1-K) and n-paraffin solvent (Norpar 15), both obtained from Imperial Oil Ltd. To determine the optimum level of initial biomass concentration, n-paraffin concentration, iron concentration and temperature for the production of citric acid, a central composite design was developed using 200 ml batch flask fermentations. The design involved conducting 31 batch flask fermentations under various combinations of high and low values of these four parameters. These optimum levels of the above operating parameters were implemented in larger scale (7litre) fermentations. These fermentations were conducted in a 14L Chemap fermentor. The fermentations investigated the effects of aeration, agitation (mechanical agitation from the fermentor and an external agitator), and batch versus fed-batch systems on biomass and citric acid production. (Abstract shortened by UMI.)
Comparison of Depletion Strategies for the Enrichment of Low-Abundance Proteins in Urine
Creators: name: Filip, Szymon
name: Vougas, Konstantinos
name: Zoidakis, Jerome
name: Latosinska, Agnieszka
name: Mullen, William
name: Spasovski, Goce
name: Mischak, Harald
name: Vlahou, Antonia
name: Jankowski, Joachim
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Proteome analysis of complex biological samples for biomarker identification remains challenging, among others due to the extended range of protein concentrations. High-abundance proteins like albumin or IgG of plasma and urine, may interfere with the detection of potential disease biomarkers. Currently, several options are available for the depletion of abundant proteins in plasma. However, the applicability of these methods in urine has not been thoroughly investigated. In this study, we compared different, commercially available immunodepletion and ion-exchange based approaches on urine samples from both healthy subjects and CKD patients, for their reproducibility and efficiency in protein depletion. A starting urine volume of 500 μL was used to simulate conditions of a multi-institutional biomarker discovery study. All depletion approaches showed satisfactory reproducibility (n=5) in protein identification as well as protein abundance. Comparison of the depletion efficiency between the unfractionated and fractionated samples and the different depletion strategies, showed efficient depletion in all cases, with the exception of the ion-exchange kit. The depletion efficiency was found slightly higher in normal than in CKD samples and normal samples yielded more protein identifications than CKD samples when using both initial as well as corresponding depleted fractions. Along these lines, decrease in the amount of albumin and other targets as applicable, following depletion, was observed. Nevertheless, these depletion strategies did not yield a higher number of identifications in neither the urine from normal nor CKD patients. Collectively, when analyzing urine in the context of CKD biomarker identification, no added value of depletion strategies can be observed and analysis of unfractionated starting urine appears to be preferable.
Understanding University Students' Journey Using Advanced Data Analytics
Creators: name: Jayaratna, Sameera
Publisher: name: Swinburne
Year: 2024

description: Motivated by the increasing influence of data analytics in the higher education sector, this thesis focuses on enhancing the effectiveness and quality of an undergraduate student's journey. An undergraduate student's journey begins when they enrol at a university and ends once employed in the graduate labour market. Findings of this research benefits stakeholders of education, such as educational policymakers, education providers, current and prospective students in solving a variety of problems including student drop-out, low course satisfaction, and undesirable graduate employment outcomes.
Supplementary document for Electrically injected GeSn lasers on Si operating up to 100 K - 4702364.pdf
Creators: name: Zhou, Yiyin
name: Miao, Yuanhao
name: Ojo, Solomon
name: Tran, Huong
name: Abernathy, Grey
name: Grant, Joshua
name: Amoah, Sylvester
name: Salamo, Gregory
name: Du, Wei
name: Liu, Jifeng
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement 1
CARD9 Forms an Alternative CBM Complex in Richter Syndrome
Creators: name: Maier, Julia
name: Lechel, André
name: Marienfeld, Ralf
name: Barth, Thomas F. E.
name: Möller, Peter
name: Mellert, Kevin
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Richter syndrome
subject: chronic lymphocytic leukemia
subject: NF-κB
subject: DDC 610 / Medicine & health
subject: Leukemia, Lymphocytic, Chronic, B-Cell
subject: NF-kappa B
subject: Chronisch-lymphatische Leukämie
subject: Nuklearfaktor Kappa B

description: Simple Summary The transformation process of chronic lymphocytic leukemia into an aggressive lymphoma, called Richter syndrome (RS), is incompletely understood, and therapeutic options are limited. Here, we report CARD9 to be expressed in a subset of RS tissue specimen and in the first and only available RS cell line, U-RT1. In U-RT1, CARD9 attaches to BCL10 and MALT1, and knockdown of CARD9 leads to a significant reduction in cell viability. We hypothesized that CARD9 plays an oncogenic role in RS through the activation of NF-κB signaling. Our findings may help to extend the current knowledge about the pathogenesis of RS and promote the development of targeted therapies for this aggressive disease. Abstract Richter syndrome (RS) is defined as the transformation of chronic lymphocytic leukemia (CLL) into an aggressive lymphoma, mostly diffuse large B-cell lymphoma (DLBCL). Despite intensive therapy, patients with RS have an unfavorable clinical outcome. The detailed pathobiology of Richter transformation still needs to be elucidated. Here, we report high mRNA and protein levels of CARD9 in the RS cell line U-RT1. Co-immunoprecipitation revealed the assembly of a CBM complex using CARD9 instead of CARD11. CARD9 is known to be an activator of NF-кB signaling in myeloid cells. U-RT1 Western blot analyses showed phosphorylation of IκB as well as IKK, indicating a constitutively active canonical NF-кB pathway. This was further supported by the significant reduction in cell viability and CYLD cleavage products after CARD9 siRNA knockdown. We also showed immunostaining for CARD9 in 53% of cases analyzed in a series of RS tissue specimens, whereas other lymphomas rarely show CARD9 expression. This is the first report on ectopic expression and function of CARD9 in an aggressive B-cell lymphoma. Our findings suggest that CARD9 may contribute to the pathogenesis of RS.
Immunohistochemical Analysis of the Natural Killer Cell Cytotoxicity Pathway in Human Abdominal Aortic Aneurysms
Creators: name: Hinterseher, Irene
name: Schworer, Charles M.
name: Lillvis, John H.
name: Stahl, Elizabeth
name: Erdman, Robert
name: Gatalica, Zoran
name: Tromp, Gerard
name: Kuivaniemi, Helena
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: human aorta
subject: immunohistochemistry
subject: double-staining
subject: AAA
subject: aortic aneurysm
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Our previous analysis using genome-wide microarray expression data revealed extreme overrepresentation of immune related genes belonging the Natural Killer (NK) Cell Mediated Cytotoxicity pathway (hsa04650) in human abdominal aortic aneurysm (AAA). We followed up the microarray studies by immunohistochemical analyses using antibodies against nine members of the NK pathway (VAV1, VAV3, PLCG1, PLCG2, HCST, TYROBP, PTK2B, TNFA, and GZMB) and aortic tissue samples from AAA repair operations (n = 6) and control aortae (n = 8) from age-, sex- and ethnicity-matched donors from autopsies. The results confirmed the microarray results. Two different members of the NK pathway, HCST and GRZB, which act at different steps in the NK-pathway, were actively transcribed and translated into proteins in the same cells in the AAA tissue demonstrated by double staining. Furthermore, double staining with antibodies against CD68 or CD8 together with HCST, TYROBP, PTK2B or PLCG2 revealed that CD68 and CD8 positive cells expressed proteins of the NK-pathway but were not the only inflammatory cells involved in the NK-pathway in the AAA tissue. The results provide strong evidence that the NK Cell Mediated Cytotoxicity Pathway is activated in human AAA and valuable insight for future studies to dissect the pathogenesis of human AAA.
A Computational Workflow for Interdisciplinary Deep Learning Projects utilizing bwHPC Infrastructure
Creators: name: Schilling, Marcel P.
name: Neumann, Oliver
name: Scherr, Tim
name: Cui, Haijun
name: Popova, Anna A.
name: Levkin, Pavel A.
name: Götz, Markus
name: Reischl, Markus
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Computational Workflow
subject: Interdisciplinary Projects
subject: Biomedical Image Processing
subject: Deep Neural Networks
subject: HPC
subject: HTC
subject: DDC 000 / Computer science, information & general works
subject: DDC 620 / Engineering & allied operations
subject: Interdisciplinary research
subject: High performance computing
subject: Deep learning
subject: High Temperature Capillarity
subject: Hochleistungsrechnen

description: Deep neural networks have the capability to solve complex tasks through accurate function approximation. The process from submitting domain data and defining process requirements to analyzed data consists of multiple steps, disallowing a simplistic straightforward procedure. It follows that one of the core questions is: how does an application development process facilitating interaction between data scientists and domain experts look like? Practically, two connected challenges need to be addressed. Firstly, it requires a solution for handling large amounts of domain-specific data. Secondly, when dealing with complex deep neural networks, it is essential to find a concept of how model training can be designed in an computationally efficient manner. While tailored solutions for addressing these challenges in interdisciplinary deep learning projects exist, a comprehensive and structured approach is missing. Hence, we present a computational workflow to enhance these kinds of projects concerning data handling, integration of cluster computing resources such as bwHPC infrastructure, and development processes. We exemplify our proposal by means of a biomedical image analysis project.
Becoming Canadian. Federal-provincial Indian policy and the integration of Natives, 1945-1969: The case of Ontario.
Creators: name: Carisse, Karl.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: History, Canadian.

description: Since Confederation, the federal government has pursued a policy of assimilation toward Canada's First Nations. Measures such as the Indian Act, the creation of reserves, and numerous treaties were implemented to "civilize" Natives, dispose of Aboriginal land rights, and ultimately integrate Natives within Canadian society. However, by the Second World War, most federal authorities realized that the government's policy had failed. Thus, other means were adopted to achieve the goal of assimilation. The new method, first elaborated in the late 1940s, proposed that the federal government devolve its jurisdiction over First Nations to the provincial governments so that Natives could receive provincial services on the same basis as non-Natives and thus be considered "normal" citizens. Consequently, federal Indian administration, the Indian Act, and the special status of Natives could be abolished since they had received full citizenship with all its benefits and responsibilities. Throughout the 1950s and 1960s, the federal and provincial governments signed agreements to arrive at this end with Ontario leading the way. However, in 1969, this method of integration met the same forsaken fate as its predecessors. This thesis will examine the federal government's integration policy from 1945 to 1969 by focusing, but not limiting itself, to the agreements that were signed between Ontario and Ottawa regarding the delivery of social services. The study will also look at the Native reaction toward this policy and the rise of opposition which led to its demise.