cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Biophysical characterisation of muscle-specific proteins involved in sarcomere signalling and elasticity: MuRF1, Twitchin kinase & cardiac titin
Creators: name: Franke, Barbara
Publisher: name: University of Liverpool Repository
Year: 2013

description: Striated muscle has the ability to remodel itself in response to mechanical stress and (patho) physiological factors, through the various signalling pathways, which govern myofibril turnover. One such pathway, involving MuRF1 is the ubiquitin proteasome system, which targets proteins for degradation. The focus of this work has been placed on investigating muscle specific proteins involved in sarcomere signalling and elasticity. Emphasis has been placed in elucidating the crystal structure of the coiled coil domain of MuRF1 to 2.1Å resolution. This domain has been thought to govern homodimerization of this E3 ubiquitin ligase, but we show that the coiled coil potential of this fragment in isolation is limited, and has a promiscuous sequence capable of establishing parallel and anti-parallel self-associative interactions. We have concluded that this domain requires the presence of either the N-terminal B-box domain to set the registry of the coiled-coil or the C-terminal COS-box domain. We predict that the latter forms two short helices, which interact with the coiled coil domain to form a clamp that stabilizes the dimer interaction. MuRF1 binds to the titin cytoskeleton vicinal to the titin kinase domain. We have also examined the titin homologue twitchin (from C. elegans) to gain insight into how the kinase domain is activated by sensing mechanical strain. We have determined that these kinase domains are autoinhibited by two regulatory tails flanking the catalytic core, and can be activated by stretching forces that displace the N-terminal tail. Finally, to further understand the ability of the titin I-band to contribute to sarcomere elasticity and end-filament formation work has been carried out on a five- domain construct of the distal I-band. Preliminary results suggest that there may be key Ig “catch” domains, which are deterministic for inducing self-assembly of titin.
States in non-associative quantum mechanics: Uncertainty relations and semiclassical evolution
Creators: name: Bojowald, Martin
name: Brahma, Suddhasattwa
name: Buyukcam, Umut
name: Strobl, Thomas
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: A non-associative algebra of observables cannot be represented as operators on a Hilbert space, but it may appear in certain physical situations. This article employs algebraic methods in order to derive uncertainty relations and semiclassical equations, based on general properties of quantum moments.
description: 23 pages
Protoplanetary Disk Masses in the Young NGC 2024 Cluster
Creators: name: Mann, Rita K.
name: Andrews, Sean M.
name: Eisner, Josh A.
name: Williams, Jonathan P.
name: Meyer, Michael R.
name: Di Francesco, James
name: Carpenter, John M.
name: Johnstone, Doug
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present the results from a Submillimeter Array survey of the 887 micron continuum emission from the protoplanetary disks around 95 young stars in the young cluster NGC 2024. Emission was detected from 22 infrared sources, with flux densities from ~5 to 330 mJy; upper limits (at 3sigma) for the other 73 sources range from 3 to 24 mJy. For standard assumptions, the corresponding disk masses range from ~0.003 to 0.2Msolar, with upper limits at 0.002--0.01Msolar. The NGC 2024 sample has a slightly more populated tail at the high end of its disk mass distribution compared to other clusters, but without more information on the nature of the sample hosts it remains unclear if this difference is statistically significant or a superficial selection effect. Unlike in the Orion Trapezium, there is no evidence for a disk mass dependence on the (projected) separation from the massive star IRS2b in the NGC 2024 cluster. We suggest that this is due to either the cluster youth or a comparatively weaker photoionizing radiation field.
description: ApJ, in press
title: Diastereoselective synthesis of syn-1,3-polyols and studies towards the C1-C31 and C32-C52 fragments of amphidinol 3
Creators: name: Grisin, Aleksandr
Publisher: name: University of Liverpool Repository
Year: 2013

description: Diastereoselective Synthesis of syn-1,3-Polyols The stereoselective construction of polyacetate 1,3-diols has attracted considerable attention due to the ubiquity of this motif in complex biologically active polyene macrolides (amphotericin B, RK-397, mycoticin, candidin). We have developed a highly stereoselective bismuth(III)-mediated two-component hemiacetal/oxa-conjugate addition reaction, which directly provides syn-1,3-diols in the form of cyclic acetals having an adjacent electron-withdrawing group in the form of aldehydes and ketones. The scope and limitations of this transformation were examined and culminated with the synthesis of the C18-C28 fragment of antibiotic RK-397. Studies towards the C1-C31 and C32-C52 Fragments of Amphidinol 3 Temporary-tethered reactions provide an important strategy for target- directed synthesis, since they circumvent the problems encountered with entropically unfavorable reactions. The temporary silicon-tethered ring-closing metathesis (TST- RCM) allows for the highly (Z)-selective coupling of mixed silaketals in the formation of the medium sized rings. The latter compounds can undergo a substrate controlled stereoselective electrophilic functionalisation, for example, hydroboration, dihydroxylation or epoxidation, and produce polyoxygenated motifs that are present in many biologically important natural products. In the course of these studies we have developed a highly convergent asymmetric synthesis of the C1-C31 polyol fragment of amphidinol 3, where the TST-RCM/hydroboration reaction is successfully employed for the efficient coupling ii of the C16-C23 and C24-C30 units of the natural product with concomitant introduction of the crucial propionate-type C23-C24 stereocentres. In the final part of thesis the investigation of the stereoselective dihydroxylation reaction of mixed syn and anti eight-membered cyclic silaketals was carried out. The resulting oxygenated products can be efficiently transformed via an intramolecular cyclisation of δ-hydroxy epoxides into the highly substituted syn- and anti-tetrahydropyrans (THPs), a strategy that could also have application in related natural products, for example, ladder polyether polyketides. The merit of the developed methodology was highlighted in the asymmetric synthesis of the common C31(52)-C39(44) THP fragment of amphidinol 3, which could be ultimately used in the bidirectional route towards the bis-THP segment of the natural product.
Performance of Comorbidity, Risk Adjustment, and Functional Status Measures in Expenditure Prediction for Patients With Diabetes
Creators: name: Maciejewski, M. L.
name: Liu, C.-F.
name: Fihn, S. D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: OBJECTIVE—To compare the ability of generic comorbidity and risk adjustment measures, a diabetes-specific measure, and a self-reported functional status measure to explain variation in health care expenditures for individuals with diabetes.RESEARCH DESIGN AND METHODS—This study included a retrospective cohort of 3,092 diabetic veterans participating in a multisite trial. Two comorbidity measures, four risk adjusters, a functional status measure, a diabetes complication count, and baseline expenditures were constructed from administrative and survey data. Outpatient, inpatient, and total expenditure models were estimated using ordinary least squares regression. Adjusted R2 statistics and predictive ratios were compared across measures to assess overall explanatory power and explanatory power of low- and high-cost subgroups.RESULTS—Administrative data–based risk adjusters performed better than the comorbidity, functional status, and diabetes-specific measures in all expenditure models. The diagnostic cost groups (DCGs) measure had the greatest predictive power overall and for the low- and high-cost subgroups, while the diabetes-specific measure had the lowest predictive power. A model with DCGs and the diabetes-specific measure modestly improved predictive power.CONCLUSIONS—Existing generic measures can be useful for diabetes-specific research and policy applications, but more predictive diabetes-specific measures are needed.
Science and Technology Libraries: Collections and Services
Creators: name: Sandy, John H.
name: Skinner, A.E.
name: Ardis, Susan
name: White, Betty J.
name: Smith, Martin
name: Phillips, Virginia
Publisher: name: The University of Texas at Austin
Year: 1980
Subjects: branch libraries
library services
University of Texas Libraries

description: This publication is a booklet describing the collections, services, and facilities offered by the science and engineering libraries at the University of Texas at Austin in 1980. The booklet was written by branch librarians John H. Sandy, A.E. Skinner, Susan Ardis, Betty J. White, and Martin Smith, with assistance from Virginia Phillips, assistant director for branch services.
title: The Dilemma of an Urhobo Baptist regarding Funeral rites: an Appraisal
Creators: name: Ajagbe, Samson
name: Ajagbe, Samson O Temioda
name: Ajagbe, Samson O Temioda
Publisher: name: University of Liverpool Repository
Year: 2013

description: Michael P. Adogbo argued that religion and culture are intrinscally interwoven in the Urhobo mindset. Addressing similar phenomenon generally among Africans, Musimbi K. A. Kanyoro stated that African Christian ‘often walks with one foot in African religion and culture and another in the church and Western culture.’ This phenomenon which Kanyoro argued that could be destructive if not well managed is the main issue examined more specifically in the context of culture and religion among Urhobo Baptists. The approach of the Delta State Baptist Conference (DSBC) to this reality among the Urhobo Baptists has created religious/cultural dichotomy in their funeral rites which this research addressed by examining two key questions: First, Could an Urhobo Baptist be faithful to the Baptist faith the way it is articulated in the DSBC policies, in view of Urhobo cultural identity during funeral ceremonies? Second, Could DSBC hold to its policy on burial rites and at the same time be relevant within the Urhobo society? My experiences as a pastor among Urhobo Baptists enabled me to evaluate symbols and functions of Urhobo funeral rites in the context of some ethnographic, anthropological, and hermeneutical theories examined in this study. A major discovery is that Urhobo Baptists hold on to certain key aspects of Urohobo funeral tradition evaluated in this study in spite of their conversion to the Baptist faith. Similarly, to the Urhobo Baptists, as analysed later in the thesis, the purpose of Urhobo funeral rites does not contradict the Baptist faith. These led to the major argument in this thesis that integration of certain vital aspects of Urhobo funeral rites into the Baptist funeral process is possible, valuable and advantageous for discouraging dual funeral faith practices among Urhobo Baptists.
title: PROCURING PRODUCE IN A RURAL, APPALACHIAN COUNTY: A THEMATIC ANALYSIS OF COMMUNITY MEMBER EXPERIENCES
title: A THEMATIC ANALYSIS OF COMMUNITY MEMBER EXPERIENCES
titleType: Subtitle
Creators: name: Blincoe, Caroline
Publisher: name: University of Kentucky Libraries
Year: 2021
Subjects: subject: FOS: Health sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Rates of obesity and other health disparities are exceptionally high in rural Appalachian counties compared to the nation as a whole. One causal factor of these health disparities in Appalachian counties is the inequitable allocation of healthy food. Food insecurity and the local food environment are large drivers for obesity experienced by Martin County, Kentucky residents. Successful socioecological model (SEM) and policy, systems, and environmental (PSE) interventions have shown promising results in reducing obesity and enhancing food security in this population. Through the transcription of semi-structured focus group interviews, thematic analysis aimed to obtain perspectives on the local food system. This study identified major barriers, facilitators, and existing food programs relative to produce procurement in Martin County. Findings from this study will be used to tailor food security interventions for Appalachian counties in effort to reduce the obesity prevalence in this population.
description: Ⓒ 2021 Caroline Briscoe
Best estimation of functional linear models
Creators: name: Aletti, Giacomo
name: May, Caterina
name: Tommasi, Chiara
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistics Theory (math.ST)
subject: Methodology (stat.ME)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences

description: Observations which are realizations from some continuous process are frequent in sciences, engineering, economics, and other fields. We consider linear models, with possible random effects, where the responses are random functions in a suitable Sobolev space. The processes cannot be observed directly. With smoothing procedures from the original data, both the response curves and their derivatives can be reconstructed, even separately. From both these samples of functions, just one sample of representatives is obtained to estimate the vector of functional parameters. A simulation study shows the benefits of this approach over the common method of using information either on curves or derivatives. The main theoretical result is a strong functional version of the Gauss-Markov theorem. This ensures that the proposed functional estimator is more efficient than the best linear unbiased estimator based only on curves or derivatives.
description: the best information from the two samples of functions and derivatives: a strong version of the Gauss-Markov theorem. Relaxed an hidden hypothesis on linear independence of the Riesz representation of the Karhunen-Loeve base
Multi-Level Restricted Maximum Likelihood Covariance Estimation and Kriging for Large Non-Gridded Spatial Datasets
Creators: name: Castrillon-Candas, Julio E.
name: Genton, Marc G.
name: Yokota, Rio
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computation (stat.CO)
subject: FOS: Computer and information sciences

description: We develop a multi-level restricted Gaussian maximum likelihood method for estimating the covariance function parameters and computing the best unbiased predictor. Our approach produces a new set of multi-level contrasts where the deterministic parameters of the model are filtered out thus enabling the estimation of the covariance parameters to be decoupled from the deterministic component. Moreover, the multi-level covariance matrix of the contrasts exhibit fast decay that is dependent on the smoothness of the covariance function. Due to the fast decay of the multi-level covariance matrix coefficients only a small set is computed with a level dependent criterion. We demonstrate our approach on problems of up to 512,000 observations with a Matern covariance function and highly irregular placements of the observations. In addition, these problems are numerically unstable and hard to solve with traditional methods.
description: Spatial Statistics, Available online 10 November 2015
Preservation of  -Cell Function in Autoantibody-Positive Youth With Diabetes
Creators: name: Marcovina, S.
name: Dabelea, D.
name: Pihoker, C.
name: Anderson, A. M.
name: Mayer-Davis, E. J.
name: Imperatore, G.
name: Dolan, L. M.
name: Greenbaum, C. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: OBJECTIVETo determine the extent of β-cell function in youth with diabetes and GAD65 and/or IA2 autoantibodies.RESEARCH DESIGN AND METHODSFasting C-peptide levels from 2,789 GAD65- and/or IA2 autoantibody-positive youth aged 1–23 years from the SEARCH for Diabetes in Youth study were used. Preserved β-cell function was defined on the basis of cut points derived from the Diabetes Control and Complications Trial (DCCT) (fasting C-peptide ≥0.23 ng/ml) and from the U.S. adolescent population of the National Health and Nutrition Examination Survey (NHANES) 5th percentile for fasting C-peptide (≥1.0 ng/ml). We compared the clinical characteristics between those with and without preserved β-cell function.RESULTSWithin the first year of diagnosis, 82.9% of youth had a fasting C-peptide ≥0.23 ng/ml and 31.2% had values ≥1.0 ng/ml. Among those with ≥5 years of diabetes duration, 10.7% had preserved β-cell function based on the DCCT cutoff and 1.0% were above the 5th percentile of the NHANES population.CONCLUSIONSWithin the 1st year of diagnosis, four of five youth with autoantibody-positive diabetes have clinically significant amounts of residual β-cell function and about one-third have fasting C-peptide levels above the 5th percentile of a healthy adolescent population. Even 5 years after diagnosis, 1 of 10 has fasting C-peptide above a clinically significant threshold. These findings have implications for clinical classification of youth with diabetes as well as clinical trials aimed to preserve β-cell function after diabetes onset.
Type 1 and Type 2 Diabetes in Asian and Pacific Islander U.S. Youth: The SEARCH for Diabetes in Youth Study
Creators: name: Marcovina, S. M.
name: Yi, J. P.
name: Dabelea, D. M.
name: Beyer, J.
name: Rodriguez, B. L.
name: Dolan, L. M.
name: Mayer-Davis, E. J.
name: Waitzfelder, B. E.
name: Fujimoto, W. Y.
name: Lawrence, J. M.
name: Liu, L. L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: OBJECTIVE —Given limited reports on diabetes among U.S. Asian and Pacific Islander youth, we describe the clinical characteristics, incidence, and prevalence of diabetes among Asian, Pacific Islander, and mixed Asian–Pacific Islander youth. RESEARCH DESIGN AND METHODS —Data were collected from 245 Asian, Pacific Islander, and Asian–Pacific Islander participants in the SEARCH for Diabetes in Youth Study, a population-based study of diabetes in youth (aged 33 kg/m2. In those with type 1 diabetes, Pacific Islanders were more likely to be obese, with a mean BMI of 26 vs. 20 kg/m2 for Asian and Asian–Pacific Islander youth ( P < 0.0001). The incidence of type 1 diabetes for youth aged 0–9 years was 6.4 per 100,000 person-years and 7.4 per 100,000 person-years for youth aged 10–19 years. The incidence of type 2 diabetes was 12.1 per 100,000 person-years for youth aged 10–19 years. CONCLUSIONS —While Asian and Asian–Pacific Islanders with type 1 and type 2 diabetes had lower mean BMIs than Pacific Islanders, all Asian, Pacific Islander, and Asian–Pacific Islanders with type 2 diabetes had mean BMIs above adult ethnicity-specific definitions of obesity. While the majority of Asian, Pacific Islander, and Asian–Pacific Islander youth had type 1 diabetes, older Asian, Pacific Islander, and Asian–Pacific Islander youth (aged 10–19 years) have an incidence of type 2 diabetes almost double that of type 1 diabetes. Public health efforts to prevent type 2 diabetes and obesity in Asian, Pacific Islander, and Asian–Pacific Islander adolescents are needed.
Aspirin for primary prevention of cardiovascular events in people with diabetes: A position statement of the american diabetes association, a scientific statement of the american heart association, and an expert consensus document of the american college of cardiology foundation
Creators: name: Wilson, Peter W.
name: Mukherjee, Debabrata
name: Williams, Craig D.
name: Rosenson, Robert S.
name: Cushman, Mary
name: Inzucchi, Silvio E.
name: Kirkman, M. Sue
name: Pignone, Michael
name: Alberts, Mark J.
name: Colwell, John A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The burden of cardiovascular disease (CVD) among patients with diabetes is substantial. Individuals with diabetes are at two- to fourfold increased risk of cardiovascular events compared with age- and sex-matched individuals without diabetes. In diabetic patients over the age of 65 years, 68% of deaths are from coronary heart disease (CHD) and 16% are from stroke (1). A number of mechanisms for the increased cardiovascular risk with diabetes have been proposed, including increased tendency toward intracoronary thrombus formation (2), increased platelet reactivity (3), and worsened endothelial dysfunction (4). The increased risk for cardiovascular events and mortality in patients with diabetes has led to considerable interest in identifying effective means for cardiovascular risk reduction. Aspirin has been shown to be effective in reducing cardiovascular morbidity and mortality in high-risk patients with myocardial infarction (MI) or stroke (secondary prevention) (5). The Food and Drug Administration has not approved aspirin for use in primary prevention, and its net benefit among patients with no previous cardiovascular events is more controversial, for both patients with and without a history of diabetes (5). The U.S. Preventive Services Task Force recently updated its recommendation about aspirin use for primary prevention. The Task Force recommended encouraging aspirin use in men age 45–79 years and women age 55–79 years and not encouraging aspirin use in younger adults. They did not differentiate their recommendations based on the presence or absence of diabetes (6,7). In 2007, the American Diabetes Association (ADA) and the American Heart Association (AHA) jointly recommended that aspirin therapy (75–162 mg/day) be used as a primary prevention strategy in those with diabetes at increased cardiovascular risk, including those who are over 40 years of age or who have additional risk factors (family history of CVD, hypertension, smoking, dyslipidemia, or albuminuria) (8). These recommendations were …
title: Εννοιολογική ανάλυση του σχολικού περιβάλλοντος και ο ρόλος της παιδαγωγικής ηγεσίας στην διαμόρφωση του σχολικού κλίματος
title: Conceptual analysis of the school environment and the role of pedagogical leadership in shaping the school climate
titleType: AlternativeTitle
Creators: name: Κάρλοβιτς, Μαρία
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2023
Subjects: Εκπαιδευτική ηγεσία
Μοντέλα ηγεσίας
Σχολική κουλτούρα
Αντιλήψεις εκπαιδευτικών
Σχολικό περιβάλλον

description: Σκοπός της παρούσας μελέτης αποτέλεσε η κριτική προσέγγιση του ρόλου που διαδραματίζει η ηγεσία στην Εκπαίδευση. Ειδικότερα αναλύσαμε και καταγράψαμε τις ηγετικές θεωρίες, τα θεμελιώδη στοιχεία που την απαρτίζουν, τα μοντέλα ηγεσίας καθώς αποτυπώθηκαν και τα χαρακτηριστικά ενός ηγέτη. Με την παρούσα εργασία επιχειρείται η διερεύνηση των αντιλήψεων πέντε εκπαιδευτικών πρωτοβάθμιας εκπαίδευσης του νομού Αττικής αναφορικά με τη σημαντικότητα που διαδραματίζει η Παιδαγωγική ηγεσία στο να διαμορφώνει ένα θετικό σχολικό κλίμα και να αναπτύσσει μια σύγχρονη σχολική κουλτούρα. Η μεθοδολογία που αναπτύχθηκε περιλαμβάνει μία ποιοτική έρευνα με τη χρήση της ημιδομημένης συνέντευξης , έγινε προσπάθεια ανάδειξης των αντιλήψεων αναφορικά με το κλίμα και την κουλτούρα των εκπαιδευτικών και του διευθυντή στη σχολική μονάδα .Επίσης, έγινε αναφορά στο στυλ ηγεσίας στη διαμόρφωση θετικού κλίματος και θετικής κουλτούρας ,καθώς και τις προσδοκίες των εκπαιδευτικών για το ρόλο του αποτελεσματικού ηγέτη. Τα αποτελέσματα της ποιοτικής έρευνας ανέδειξαν εκπαιδευτικούς με θετικό πνεύμα και κοινές πεποιθήσεις μάθησης οι οποίοι θεωρούν πως η εκάστοτε Ηγεσία διαμορφώνει το κλίμα και την κουλτούρα που θα διαμορφώσει το μαθησιακό περιβάλλον. Συμφωνούν επίσης ότι οι προσδοκίες τους για να διαμορφωθεί ένα θετικό κλίμα πρέπει να δημιουργηθούν κατάλληλες συνθήκες, που θα οδηγήσουν τον Ηγέτη-Διευθυντή να γίνει πιο αποτελεσματικός και αποδοτικός. Ο ηγέτης θα πρέπει να έχει έναν συνδυασμό διοικητικών και ηγετικών ικανοτήτων και όραμα.
Liouville theory with a central charge less than one
Creators: name: Ribault, Sylvain
name: Santachiara, Raoul
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We determine the spectrum and correlation functions of Liouville theory with a central charge less than (or equal) one. This completes the definition of Liouville theory for all complex values of the central charge. The spectrum is always spacelike, and there is no consistent timelike Liouville theory. We also study the non-analytic conformal field theories that exist at rational values of the central charge. Our claims are supported by numerical checks of crossing symmetry. We provide Python code for computing Virasoro conformal blocks, and correlation functions in Liouville theory and (generalized) minimal models.
description: 24 pages, Python code available at https://github.com/ribault/bootstrap-2d-Python, v3: corrected eq. (4.6)
A strain-level dataset of phage-bacteria interactions
Creators: name: 李敏(Min Li)
Publisher: name: CNGB
Year: 2024
Subjects: Phenotype or Genotype
Proteome
Virus sequences
Multiisolate
Other
Microbiome, Virus

description: This dataset contains proteome data of 101 bacterial strains, 129 bacteriophage strains, and phenotypic data of their interaction experiments.
Costs and Consequences Associated With Newer Medications for Glycemic Control in Type 2 Diabetes
Creators: name: Pogach, L.
name: Hoerger, T.
name: Sinha, A.
name: Rajan, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: OBJECTIVENewer medications offer more options for glycemic control in type 2 diabetes. However, they come at considerable costs. We undertook a health economic analysis to better understand the value of adding two newer medications (exenatide and sitagliptin) as second-line therapy to glycemic control strategies for patients with new-onset diabetes.RESEARCH DESIGN AND METHODSWe performed a cost-effectiveness analysis for the U.S. population aged 25–64. A lifetime analytic horizon and health care system perspective were used. Costs and quality-adjusted life years (QALYs) were discounted at 3% annually, and costs are presented in 2008 U.S. dollars. We compared three glycemic control strategies: 1) glyburide as a second-line agent, 2) exenatide as a second-line agent, and 3) sitagliptin as a second-line agent. Outcome measures included QALYs gained, incremental costs, and the incremental cost-effectiveness ratio associated with each strategy.RESULTSExenatide and sitagliptin conferred 0.09 and 0.12 additional QALYs, respectively, relative to glyburide as second-line therapy. In base case analysis, exenatide was dominated (cost more and provided fewer QALYs than the next most expensive option), and sitagliptin was associated with an incremental cost-effectiveness ratio of $169,572 per QALY saved. Results were sensitive to assumptions regarding medication costs, side effect duration, and side effect–associated disutilities.CONCLUSIONSExenatide and sitagliptin may confer substantial costs to health care systems. Demonstrated gains in quality and/or quantity of life are necessary for these agents to provide economic value to patients and health care systems.
title: Locating religious liberty in the United Kingdom: religious exceptions and the role of reasonable accommodation
Creators: name: Gibson, Matt
Publisher: name: University of Liverpool Repository
Year: 2013

description: This thesis is concerned with the special protection afforded religion in United Kingdom (UK) anti-discrimination law. Initial discussions centre on the historical and normative bases for religious liberty in the UK. These debates assess the evolution of domestic legal protection of religion and critique prevailing principles (in particular, the idea of human dignity) underpinning the variety of that protection. Attention is then focused on religious exceptions in UK anti-discrimination law and the practical extent to which they assist religious interests. It is clear that such special measures are aimed at religion as a collective; they do not enhance protection at the individual level. This deficit becomes more acute when considering the limiting effects of recent UK jurisprudence, specifically claims involving religion and discrimination across employment and the provision of goods and services. A particularly problematic trend exhibited in the case law is the courts’ approach to determining justification and proportionality in indirect discrimination. Accordingly, an argument is made for additional special protection. A duty of reasonable accommodation is proposed as a separate claim route in UK anti-discrimination law for religious individuals wishing to be excused from a rule. This is advocated in the field employment, it being noted that the field of goods and services poses challenges for the introduction of such a duty. Comparative analyses with Canada and the United States (US) expose two different models of reasonable accommodation. These are applied to high-profile UK cases featuring religion and indirect discrimination in employment, revealing how reasonable accommodation might have assessed those claims differently. It is submitted that the Canadian model provides a more sophisticated proportionality analysis than its US counterpart. This approach affords a more factually nuanced analysis in balancing the religious claim with a competing legitimate aim. It is contended that such a duty also coheres with both the theory of human dignity and the notion of equality as it features in the conceptual framework of anti-discrimination law.
Dipeptidyl Peptidase IV and Incident Diabetes: The Atherosclerosis Risk in Communities (ARIC) study
Creators: name: Schmidt, M. I.
name: Heiss, G.
name: Hoogeveen, R. C.
name: Pankow, J. S.
name: Couper, D.
name: Luft, V. C.
name: Duncan, B. B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Dipeptidyl peptidase IV (DPP-IV) is not only important in β-cell function but also has proinflammatory actions. We aimed to investigate whether it could act as a link between low-grade chronic inflammation and diabetes.
title: Αξιοποίηση νέων τεχνολογιών και εκπαιδευτικών λογισμικών για την εκπαίδευση μαθητών με ΔΕΠ-Υ στα πλαίσια της συμπερίληψης
title: Utilization of new technologies and educational software for the education of students with ADHD in the context of inclusion
titleType: AlternativeTitle
Creators: name: Μέλη, Καλλιόπη
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2023
Subjects: ΔΕΠ-Υ
Συμπερίληψη
Επιτελικές λειτουργίες
Μνήμη εργασίας
Απροσεξία

description: Η Διαταραχή Ελλειμματικής Προσοχής - Υπερκινητικότητα (ΔΕΠ-Υ), αποτελεί μια νευροαναπτυξιακή διαταραχή οργανικής αιτιολογίας που χαρακτηρίζεται από ένα εύρος συμπτωμάτων τα οποία επηρεάζουν τη λειτουργικότητα του παιδιού και του προκαλούν σημαντικές δυσκολίες σε πολλούς τομείς της καθημερινής του ζωής. Τα τρία βασικά χαρακτηριστικά της είναι η απροσεξία, η υπερκινητικότητα και η παρορμητικότητα. Η εμφάνισή της αποδίδεται κυρίως σε γενετικούς παράγοντες και σε ένα μικρό ποσοστό σε περιβαλλοντικούς. Ταξινομείται σε τρεις μορφές ανάλογα με τα χαρακτηριστικά που εμφανίζονται - Απρόσεκτος Τύπος, Υπερκινητικός - Παρορμητικός, Συνδυασμένος Τύπος. Σύμφωνα με το επίσημο εγχειρίδιο τυπολογικής ταξινόμησης DSM IV τα συμπτώματα πρέπει να έχουν κάνει την εμφάνισή τους πριν από το 7ο έτος ηλικίας του παιδιού και να μην αντιστοιχούν στο αναπτυξιακό του επίπεδο. Υπάρχει μια πολύπλευρη προσέγγιση όσον αφορά τη θεραπευτική παρέμβαση για τη ΔΕΠ-Υ αφού σχεδόν όλοι οι τομείς της ζωή του παιδιού φαίνεται να επηρεάζονται. Η συμπεριληπτική εκπαίδευση αποτελεί κεντρική ιδέα σε όλα τα σύγχρονα εκπαιδευτικά συστήματα και σε συνδυασμό με την αξιοποίηση των νέων τεχνολογιών συμβάλει τον ριζικό μετασχηματισμό του σχολείου ώστε να μπορεί να ανταποκριθεί αποτελεσματικότερα στις ανάγκες όλων μαθητών. Οι δυνατότητες που παρέχουν οι νέες τεχνολογίες συμβάλουν στην καλύτερη πρόσβαση στη γνώση και στην ανάπτυξη δεξιοτήτων, παρέχοντας ανάπτυξη κινήτρων και ενίσχυση της ανακαλυπτικής μάθησης. Ενδεδειγμένα εκπαιδευτικά λογισμικά μπορούν να χρησιμοποιηθούν συμπληρωματικά με τις παραδοσιακές μεθόδους διδασκαλίας εμπλουτίζοντας και καθιστώντας τη μάθηση περισσότερο ενδιαφέρουσα προσαρμοσμένη στις ιδιαίτερες ανάγκες των παιδιών με ΔΕΠ-Υ.
DURATION-1: Exenatide Once Weekly Produces Sustained Glycemic Control and Weight Loss Over 52 Weeks
Creators: name: Taylor, K. L.
name: Porter, L. E.
name: Shen, L. Z.
name: Buse, J. B.
name: Trautmann, M.
name: Hu, H.
name: Kim, T.
name: Walsh, B.
name: Wilhelm, K.
name: Drucker, D. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: OBJECTIVEIn the Diabetes Therapy Utilization: Researching Changes in A1C, Weight and Other Factors Through Intervention with Exenatide Once Weekly (DURATION-1) study, the safety and efficacy of 30 weeks of treatment with the glucagon-like peptide-1 receptor agonist exenatide once weekly (exenatide QW; 2 mg) was compared with exenatide BID in 295 patients with type 2 diabetes. We now report the safety and efficacy of exenatide QW in 1) patients who continued treatment for an additional 22 weeks (52 weeks total) and 2) patients who switched from exenatide BID to exenatide QW after 30 weeks.RESEARCH DESIGN AND METHODSIn this randomized, multicenter, comparator-controlled, open-label trial, 258 patients entered the 22-week open-ended assessment phase (n = 128 QW-only; n = 130 BID→QW). A1C, fasting plasma glucose (FPG), body weight, blood pressure, fasting lipids, safety, and tolerability were assessed.RESULTSPatients continuing exenatide QW maintained A1C improvements through 52 weeks (least squares mean −2.0% [95% CI −2.1 to −1.8%]). Patients switching from exenatide BID to exenatide QW achieved further A1C improvements; both groups exhibited the same A1C reduction and mean A1C (6.6%) at week 52. At week 52, 71 and 54% of all patients achieved A1C <7.0% and ≤6.5%, respectively. In both treatment arms, FPG was reduced by >40 mg/dl, and body weight was reduced by >4 kg after 52 weeks. Nausea occurred less frequently in this assessment period and was predominantly mild. No major hypoglycemia was observed.CONCLUSIONExenatide QW elicited sustained improvements in glycemic control and body weight through 52 weeks of treatment. Patients switching to exenatide QW experienced further improvements in A1C and FPG, with sustained weight loss.
Believing through belonging: a sociological study of Christian conversion of Chinese migrants in Britain
Creators: name: Li, Richard
Publisher: name: Loughborough University
Year: 2019
Subjects: subject: 169999 Studies in Human Society not elsewhere classified
subject: FOS: Sociology

description: This study is the first in-depth sociological inquiry into Chinese migrant Christian communities in Britain, through the examination of different pathways to and stages of conversion to Christianity among contemporary Chinese migrants. In the last four decades, the rapid growth of Christianity among the Chinese worldwide has also sparked a growth in academic research. The Chinese has become the fourth largest ethnic minority group in Britain. However, their religious attachments and experiences have hitherto received scant scholarly attention. The study seeks to fill the identified research gap by providing explorative sociological accounts of the socio-religious dynamics of the Chinese Christian communities in Britain, with a main focus on the issue of religious conversion. It draws on social scientific theories of religious conversion to develop a sequential framework for the documentation of typical conversion trajectories among Chinese Christian converts in Britain. The study takes a qualitative approach, employing in-depth interviews and multi-sited ethnography as the main investigative instruments, documenting three stages, namely, encounter, initiation and commitment, in Christian conversion. It proposes a thesis of believing-through-belonging for the understanding of Christian conversion of Chinese migrants in Britain. Moreover, the thesis points to the commitment-centred conversion, as promulgated by Chinese migrant Christian institutions and practiced by individual Chinese Christians, as a key to understand the continuous growth of Chinese Christian communities in Britain.
Epidemiologic Relationships Between A1C and All-Cause Mortality During a Median 3.4-Year Follow-up of Glycemic Treatment in the ACCORD Trial
Creators: name: Seaquist, E. R.
name: Malozowski, S.
name: Margolis, K. L.
name: Byington, R. P.
name: Schnall, A.
name: Buse, J. B.
name: Goff, D. C.
name: Probstfield, J. L.
name: Brillon, D. J.
name: Cohen, R. M.
name: Riddle, M. C.
name: Ambrosius, W. T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: OBJECTIVERandomized treatment comparing an intensive glycemic treatment strategy with a standard strategy in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial was ended early because of an unexpected excess of mortality in the intensive arm. As part of ongoing post hoc analyses of potential mechanisms for this finding, we explored whether on-treatment A1C itself had an independent relationship with mortality.RESEARCH DESIGN AND METHODSParticipants with type 2 diabetes (n = 10,251 with mean age 62 years, median duration of diabetes 10 years, and median A1C 8.1%) were randomly assigned to treatment strategies targeting either A1C <6.0% (intensive) or A1C 7.0–7.9% (standard). Data obtained during 3.4 (median) years of follow-up before cessation of intensive treatment were analyzed using several multivariable models.RESULTSVarious characteristics of the participants and the study sites at baseline had significant associations with the risk of mortality. Before and after adjustment for these covariates, a higher average on-treatment A1C was a stronger predictor of mortality than the A1C for the last interval of follow-up or the decrease of A1C in the first year. Higher average A1C was associated with greater risk of death. The risk of death with the intensive strategy increased approximately linearly from 6–9% A1C and appeared to be greater with the intensive than with the standard strategy only when average A1C was >7%.CONCLUSIONSThese analyses implicate factors associated with persisting higher A1C levels, rather than low A1C per se, as likely contributors to the increased mortality risk associated with the intensive glycemic treatment strategy in ACCORD.
Incretin-Based Therapies for the Treatment of Type 2 Diabetes: Evaluation of the Risks and Benefits
Creators: name: Sherman, S. I.
name: Drucker, D. J.
name: Gorelick, F. S.
name: Buse, J. B.
name: Bergenstal, R. M.
name: Sherwin, R. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Limited evidence suggests that GLP-I may also preserve ventricular function and improve outcomes in human subjects with heart failure or myocardial infarction (11,12). [...] both exenatide and liraglutide reduce blood pressure, body weight, and plasma lipid profiles in subjects with type 2 diabetes (13), raising the hope that longterm treatment with these agents may reduce the incidence of cardiovascular events.\n However, two safety issues have been raised - pancreatitis and medullary carcinoma of the thyroid.
Magnesium Intake in Relation to Systemic Inflammation, Insulin Resistance, and the Incidence of Diabetes
Creators: name: Yokota, K.
name: Jacobs, D. R.
name: He, K.
name: Kim, D. J.
name: Loria, C.
name: Liu, K.
name: Xun, P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: OBJECTIVETo investigate the long-term associations of magnesium intake with incidence of diabetes, systemic inflammation, and insulin resistance among young American adults.RESEARCH DESIGN AND METHODSA total of 4,497 Americans, aged 18–30 years, who had no diabetes at baseline, were prospectively examined for incident diabetes based on quintiles of magnesium intake. We also investigated the associations between magnesium intake and inflammatory markers, i.e., high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and fibrinogen, and the homeostasis model assessment of insulin resistance (HOMA-IR).RESULTSDuring the 20-year follow-up, 330 incident cases of diabetes were identified. Magnesium intake was inversely associated with incidence of diabetes after adjustment for potential confounders. The multivariable-adjusted hazard ratio of diabetes for participants in the highest quintile of magnesium intake was 0.53 (95% CI, 0.32–0.86; Ptrend < 0.01) compared with those in the lowest quintile. Consistently, magnesium intake was significantly inversely associated with hs-CRP, IL-6, fibrinogen, and HOMA-IR, and serum magnesium levels were inversely correlated with hs-CRP and HOMA-IR.CONCLUSIONSMagnesium intake was inversely longitudinally associated with incidence of diabetes in young American adults. This inverse association may be explained, at least in part, by the inverse correlations of magnesium intake with systemic inflammation and insulin resistance.
Prevalence of the Metabolic Syndrome Among U.S. Workers
Creators: name: McCollister, K. E.
name: LeBlanc, W. G.
name: Fleming, L. E.
name: Goodman, E.
name: Arheart, K. L.
name: Davila, E. P.
name: Caban-Martinez, A. J.
name: Clark, J. C.
name: Clarke, T.
name: Florez, H.
name: Lee, D. J.
name: Christ, S. L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: OBJECTIVEDifferences in the prevalence of cardiovascular disease (CVD) and its risk factors among occupational groups have been found in several studies. Certain types of workers (such as shift workers) may have a greater risk for metabolic syndrome, a precursor of CVD. The objective of this study was to assess the differences in prevalence and risk of metabolic syndrome among occupational groups using nationally representative data of U.S. workers.RESEARCH DESIGN AND METHODSData from 8,457 employed participants (representing 131 million U.S. adults) of the 1999–2004 National Health and Nutrition Examination Survey were used. Unadjusted and age-adjusted prevalence and simple and multiple logistic regression analyses were conducted, adjusting for several potential confounders (BMI, alcohol drinking, smoking, physical activity, and sociodemographic characteristics) and survey design.RESULTSOf the workers, 20% met the criteria for the metabolic syndrome, with “miscellaneous food preparation and food service workers” and “farm operators, managers, and supervisors” having the greatest age-adjusted prevalence (29.6–31.1%) and “writers, artists, entertainers, and athletes,” and “engineers, architects, scientists” the lowest (8.5–9.2%). In logistic regression analyses “transportation/material moving” workers had significantly greater odds of meeting the criteria for metabolic syndrome relative to “executive, administrative, managerial” professionals (odds ratio 1.70 [95% CI 1.49–2.52]).CONCLUSIONSThere is variability in the prevalence of metabolic syndrome by occupational status, with “transportation/material moving” workers at greatest risk for metabolic syndrome. Workplace health promotion programs addressing risk factors for metabolic syndrome that target workers in occupations with the greatest odds may be an efficient way to reach at-risk populations.
title: Trust management, privacy, authorization, and authentication in cloud computing environments
title: Διαχείριση εμπιστοσύνης, ιδιωτικότητα, εξουσιοδότηση και αυθεντικοποίηση σε νεφοϋπολογιστικά περιβάλλοντα
titleType: AlternativeTitle
Creators: name: Γεωργιοπούλου, Ζαφειρούλα
name: Georgiopoulou, Zafeiroula
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2022
Subjects: subject: Νεφελώδης υπολογιστική
subject: Μοντέλα εμπιστοσύνης
subject: Μετρική εμπιστοσύνης
subject: Ιδιωτικότητα
subject: Προσωπικά δεδομένα

description: Η συγκεκριμένη διδακτορική διατριβή πραγματεύεται την ασφάλεια σε επίπεδο εμπιστοσύνης, ιδιωτικότητας και αυθεντικοποίησης σε νεφοϋπολογιστικά συστήματα. Στο πλαίσιο εύρεσης μέτρων για την εξάλειψη των κίνδυνων ορίσθηκαν οι παράγοντες που επηρεάζουν την εμπιστοσύνη του νέφους προς το χρήστη και αναπτύχθηκε αντίστοιχο μοντέλο εμπιστοσύνης με τις κατάλληλες μετρικές. Το μοντέλο προσομοιώθηκε στο περιβάλλον ενός πανεπιστημίου. Στο πλαίσιο επίσης της παρούσας διατριβής αναλύθηκε πώς ένας πάροχος υπηρεσιών νεφούπολογιστικού νέφους θα επιτύχει τη συμμόρφωση του με το Γενικό Κανονισμό για την Προστασία των Δεδομένων (GDPR) προτείνοντας τεχνικά και οργανωτικά μέτρα. Παράλληλα μελετήθηκε μέθοδος και μετρική αποτίμησης ιδιωτικότητας λαμβάνοντας υπόψη την φύση του οργανισμού και την εφαρμογή του GDPR.
Survivable mobile telecommunication systems
Creators: name: Μυκονιάτη, Μαρία
name: Mykoniati, Maria
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2022
Subjects: subject: Survivable systems
subject: Information security
subject: Business continuity
subject: Telecomunication systems

description: Επιβιώσιμα συστήματα είναι αυτά που έχουν την ικανότητα να διατηρούν τις υπηρεσίες τους λειτουργικές κατά την διάρκεια καταστροφών, αστοχιών, επιθέσεων κλπ. Ο βασικός στόχος αυτών των συστημάτων είναι η αντίσταση στην αποτυχία του συστήματος να παρέχει τις κρίσιμες υπηρεσίες του. Η παρούσα διατριβή περιγράφει αρχικά την έρευνα γύρω από τον ορισμό της επιβιωσιμότητας και των βασικών χαρακτηριστικών ενός επιβιώσιμου συστήματος. Στη συνέχεια, η έρευνα συνεχίζεται με τον καθορισμό των ιδιοτήτων που κάνουν ένα δίκτυο κινητής τηλεφωνίας επιβιώσιμο, έτσι όπως αυτές ορίζονται από το 3GPP Standard, και τη βιβλιογραφία. Δύο σημαντικές ελλείψεις σχετικά με τα χαρακτηριστικά ενός επιβιώσιμου συστήματος εντοπίζονται, και αναπτύσσονται δύο μεθοδολογίες που καλύπτουν αυτές τις ελλείψεις και ορίζονται ως απαραίτητες προϋποθέσεις που θα πρέπει να ληφθούν υπόψιν κατά την ανάπτυξη τέτοιων συστημάτων. Στη συνέχεια, η έρευνα ολοκληρώνεται με την ανάπτυξη της ζητούμενης μεθοδολογίας (SDLC) για την κατασκευή επιβιώσιμων δικτύων κινητής τηλεφωνίας. Η εφαρμογή της μεθοδολογίας γίνεται στη μελέτη περίπτωσης δικτύων 4ης γενιάς (4G LTE Networks) ώστε να διερευνηθεί η αποτελεσματικότητα της σε σχέση με την προϋπάρχουσα μεθοδολογία που ακολουθείται από τις εταιρίες ανάπτυξης συσκευών δικτύων κινητής τηλεφωνίας. Τέλος μία ποσοτική και ποιοτική ανάλυση των αποτελεσμάτων παρουσιάζεται ώστε να φανούν τα αποτελέσματα της απόδοσης της προτεινόμενης μεθοδολογίας.
Quantum Anomalous Hall Effect in Magnetic Insulator Heterostructure
Creators: name: Xu, Gang
name: Wang, Jing
name: Felser, Claudia
name: Qi, Xiao-Liang
name: Zhang, Shou-Cheng
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Based on ab initio calculations, we predict that a monolayer of Cr-doped (Bi,Sb)2Te3 and GdI2 heterostructure is a quantum anomalous Hall insulator with a non-trivial band gap up to 38 meV. The principle behind our prediction is that the band inversion between two topologically trivial ferromagnetic insulators can result in a non-zero Chern number, which offers a better way to realize the quantum anomalous Hall state without random magnetic doping. In addition, a simple effective model is presented to describe the basic mechanism of spin polarized band inversion in this system. Moreover, we predict that 3D quantum anomalous Hall insulator could be realized in (Bi2/3Cr1/3)2Te3/GdI2 superlattice.