cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Dissolving microneedle patch-assisted transdermal delivery of methotrexate improve the therapeutic efficacy of rheumatoid arthritis
Creators: name: Zhao, Weiman
name: Zheng, Lijie
name: Yang, Jianhui
name: Ma, Zihui
name: Tao, Xinyi
name: Wang, Qingqing
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Methotrexate (MTX) is a first-line treatment for rheumatoid arthritis (RA), but its clinical use is greatly limited by the adverse effects and poor patient compliance caused by traditional oral administration or injection. In recent years, some transdermal drug delivery systems have received considerable attention due to overcoming these shortcomings. In this study, we developed dissolving microneedle patch (DMNP) for transdermal delivery of MTX to treat RA safely and effectively. The morphology, mechanical strength, skin insertion, drug content, in vitro transdermal delivery, and other properties of DMNP were characterized. Meanwhile, the adjuvant-induced arthritis model of rats was established to investigate the therapeutic effect of MTX-loaded DMNP in vivo. The results showed that the microneedles had excellent morphology with neat array and complete needles, good puncture performance and mechanical strength, and rapid intradermal dissolution rate. In vitro transdermal delivery results indicated that microneedles could significantly increase drug transdermal permeation compared with the cream group. The pharmacological study showed that MTX-loaded DMNP significantly alleviated paw swelling, inhibit inflammatory response via downregulating the levels of TNF-α and IL-1β, relieved synovium destruction with less cartilage erosion, and slowed the progression of RA in AIA rats. Besides, DMNP presented better therapeutic performance than cream or intragastric administration at the same dosage of MTX. In conclusion, the MTX-loaded dissolving microneedle patch has advantages of safety, convenience, and high efficacy over conventional administrations, laying a foundation for the transdermal drug delivery system treatment of rheumatoid arthritis.
In-silico drug repurposing for targeting SARS-CoV-2 main protease (Mpro)
Creators: name: Sharma, Shilpa
name: Deep, Shashank
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: COVID-19, caused by novel coronavirus or SARS-CoV-2, is a viral disease which has infected millions worldwide. Considering the urgent need of the drug for fighting against this infectious disease, we have performed in-silico drug repurposing followed by molecular dynamics (MD) simulation and MM-GBSA calculation. The main protease (Mpro) is one of the best-characterized drug targets among coronaviruses, therefore, this was screened for already known FDA approved drugs and some natural compounds. Comparison of docking and MD simulation results of complexes of drugs with that of inhibitor N3 (experimentally obtained) suggests EGCG, withaferin, dolutegravir, artesunate as potential inhibitors of the main protease (Mpro). Further, in silico docking and MD simulation suggest that EGCG analogues ZINC21992196 and ZINC 169337541 may act as a better inhibitor. Communicated by Ramaswamy H. Sarma
Theoretical and computational methods for the quantification of geometrical uncertainties in nuclear reactor physics
Creators: name: Williams, Anthony John Robert
Publisher: name: Imperial College London
Year: 2018

description: This thesis examines uncertainty quantification methods applied to geometric uncertainties in the neutron transport equation. Four methods were studied; perturbation theory, Monte Carlo and intrusive and non-intrusive forms of polynomial chaos. First, perturbation theory methods were applied to small scale surface roughness on surfaces and interfaces of materials. Several problems were examined in two dimensions, including a homogeneous region with a perturbed boundary, a two region pincell with a perturbed interface and the Feinberg-Galanin model with perturbed rod radius and pitch. Analytic solutions were sought where possible and compared to numerical solutions. Intrusive and non-intrusive polynomial chaos and Monte Carlo methods were then used to examine geometric uncertainties in a single spatial dimension. These were applied to the mono-energetic neutron diffusion equation with a finite element spatial discretisation. Comparison of these uncertainty quantification methods to analytic solutions showed that they were all capable of converging the result to high accuracy but the intrusive polynomial chaos methods scaled poorly as the number of random variables was increased. Non-intrusive polynomial chaos and Monte Carlo were then used to examine two-dimensional problems using diffusion, discrete ordinates and spherical harmonic forms of the neutron transport equation. It was seen that the non-intrusive polynomial chaos method was capable of producing highly accurate statistical moments and probability density functions using significantly fewer model samples than the Monte Carlo comparisons. The final cases examined used non-intrusive polynomial chaos and Monte Carlo applied to geometric uncertainties in the neutron transport equation with an isogeometric analysis spatial discretisation. This was used due to the superior representation of conic sections with isogeometric analysis than finite element methods. It was seen that for rectilinear geometries finite elements and isogeometric analysis gave equivalent results. However, for curved surfaces isogeometric analysis was able to reduce the geometric error to a greater extent per degree of freedom. This gives greater confidence that the spatial component of a calculation has converged, enabling greater confidence in the results of uncertainty quantification. This was used to examine a pincell with uncertain spatial dimensions as well as a layer of crud deposition of varying thickness; which is an inherently random process. Finally, a mixed-oxide assembly was examined with a burnable absorber pin and 71 fuel pins with stochastic radii which showed the limits of non-intrusive polynomial chaos to represent geometric uncertainties.
Extended Nambu Models: their relation to gauge theories
Creators: name: Escobar, C. A.
name: Urrutia, L. F.
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Yang-Mills theories supplemented by an additional coordinate constraint, which is solved and substituted in the original Lagrangian, provide examples of the so called Nambu models, in the case where such constraints arise from spontaneous Lorentz symmetry breaking. Some explicit calculations have shown that, after additional conditions are imposed, Nambu models are capable of reproducing the original gauge theories, thus making Lorentz violation unobservable and allowing the interpretation of the corresponding massless gauge bosons as the Goldstone bosons arising from the spontaneous symmetry breaking. A natural question posed by this approach in the realm of gauge theories is to determine under which conditions the recovery of an arbitrary gauge theory from the corresponding Nambu model, defined by a general constraint over the coordinates, becomes possible. We refer to these theories as extended Nambu models (ENM) and emphasize the fact that the {defining coordinate} constraint is not treated as a standard gauge fixing term. At this level, the mechanism for generating the constraint is irrelevant and the case of spontaneous Lorentz symmetry breaking is taken only as a motivation, which naturally bring this problem under consideration. Using a non-perturbative Hamiltonian analysis we prove that the ENM yields the original gauge theory after we demand current conservation for all time, together with the imposition of the Gauss laws constraints as initial conditions upon the dynamics of the ENM. The Nambu models yielding electrodynamics, Yang Mills theories and linearized gravity are particular examples of our general approach.
description: 36 pages, no figures. Revised version accepted for publication in IMJP A
Hydrogen Axion Star: Metallic Hydrogen Bound to a QCD Axion BEC
Creators: name: Bai, Yang
name: Barger, Vernon
name: Berger, Joshua
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: As a cold dark matter candidate, the QCD axion may form Bose-Einstein condensates, called axion stars, with masses around $10^{-11}\,M_{\odot}$. In this paper, we point out that a brand new astrophysical object, a Hydrogen Axion Star (HAS), may well be formed by ordinary baryonic matter becoming gravitationally bound to an axion star. We study the properties of the HAS and find that the hydrogen cloud has a high pressure and temperature in the center and is likely in the liquid metallic hydrogen state. Because of the high particle number densities for both the axion star and the hydrogen cloud, the feeble interaction between axion and hydrogen can still generate enough internal power, around $10^{13}~\mbox{W}\times(m_a/5~\mbox{meV})^4$, to make these objects luminous point sources. High resolution ultraviolet, optical and infrared telescopes can discover HAS via black-body radiation.
description: 35 pages, 7 figures
Discovery of new promising USP14 inhibitors: computational evaluation of the thumb-palm pocket
Creators: name: Adelakun, Niyi
name: Obaseki, Ikponwmosa
name: Adeniyi, Ayobami
name: Fapohunda, Oluwaseun
name: Obaseki, Eseiwi
name: Omotuyi, Olaposi
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Hematology

description: Ubiquitin-specific protease 14 (USP14) is a member of the deubiquitinating enzymes (DUBs) involved in disrupting the ubiquitin-proteasome regulation system, responsible for the degradation of impaired and misfolded proteins, which is an essential mechanism in eukaryotic cells. The involvement of USP14 in cancer progression and neurodegenerative disorders has been reported. Thereof USP14 is a prime therapeutic target; hence, designing efficacious inhibitors against USP14 is central in curbing these conditions. Herein, we relied on structural bioinformatics methods incorporating molecular docking, molecular mechanics generalized born surface area (MM-GBSA), molecular dynamics simulation (MD simulation), and ADME to identify potential allosteric USP14 inhibitors. A library of over 733 compounds from the PubChem repository with >90% match to the IU1 chemical structure was screened in a multi-step framework to attain prospective drug-like inhibitors. Two potential lead compounds (CID 43013232 and CID 112370349) were shown to record better binding affinity compared to IU1, but with subtle difference to IU1-47, a 10-fold potent compound when compared to IU1. The stability of the lead molecules complexed with USP14 was studied via MD simulation. The molecules were found to be stable within the binding site throughout the 50 ns simulation time. Moreover, the protein–ligand interactions across the simulation run time suggest Phe331, Tyr476, and Gln197 as crucial residues for USP14 inhibition. Furthermore, in-silico pharmacological evaluation revealed the lead compounds as pharmacological sound molecules. Overall, the methods deployed in this study revealed two novel candidates that may show selective inhibitory activity against USP14, which could be exploited to produce potent and harmless USP14 inhibitors. Communicated by Ramaswamy H. Sarma
Compact Groups analysis using weak gravitational lensing
Creators: name: Chalela, Martín
name: Gonzalez, Elizabeth Johana
name: Lambas, Diego Garcia
name: Foëx, Gael
Publisher: name: arXiv
Year: 2017
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present a weak lensing analysis of a sample of SDSS Compact Groups (CGs). Using the measured radial density contrast profile, we derive the average masses under the assumption of spherical symmetry, obtaining a velocity dispersion for the Singular Isothermal Spherical model, $σ_V = 270 \pm 40 \rm ~km~s^{-1}$, and for the NFW model, $R_{200}=0.53\pm0.10\,h_{70}^{-1}\,\rm Mpc$. We test three different definitions of CGs centres to identify which best traces the true dark matter halo centre, concluding that a luminosity weighted centre is the most suitable choice. We also study the lensing signal dependence on CGs physical radius, group surface brightness, and morphological mixing. We find that groups with more concentrated galaxy members show steeper mass profiles and larger velocity dispersions. We argue that both, a possible lower fraction of interloper and a true steeper profile, could be playing a role in this effect. Straightforward velocity dispersion estimates from member spectroscopy yields $σ_V \approx 230 \rm ~km~s^{-1}$ in agreement with our lensing results.
description: 12 pages, 10 figures. Submitted to MNRAS
Additional file 1: Figure S1. of Methylation patterns in serum DNA for early identification of disseminated breast cancer
Creators: name: Widschwendter, Martin
name: Evans, Iona
name: Jones, Allison
name: Shohreh Ghazali
name: Reisel, Daniel
name: Ryan, Andy
name: Gentry-Maharaj, Aleksandra
name: Zikan, Michal
name: Cibula, David
name: Eichner, Johannes
name: Alunni-Fabbroni, Marianna
name: Koch, Julian
name: Janni, Wolfgang
name: Paprotka, Tobias
name: Wittenberger, Timo
name: Menon, Usha
name: Wahl, Benjamin
name: Rack, Brigitte
name: Lempiäinen, Harri
Publisher: name: figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Plant Biology
subject: FOS: Biological sciences
subject: Computational Biology
subject: Cardiology

description: Samples from the SUCCESS trial analyzed within this study. Figure S2. Samples from the UKCTOCS cohort analyzed within this study (nested case/control setting). Figure S3. Absolute pattern counts for all patterns detected in the region of marker EFC#93 in Serum Set 1 samples. Figure S4. Pattern frequency of EFC#93 serum DNAme in two prospectively independently collected cohorts. Figure S5. DNA amount per mL serum in the prospectively collected serum (Set 1 and 2), SUCCESS cohort, and UKCTOCS cohort. Figure S6. Pattern frequency for EFC#93 measured in SUCCESS serum set samples from women with no, 1–4 or ≥ 5 CTCs in the matched blood sample before (A) or after (B) chemotherapy. Figure S7. Impact of the presence (+ve, ≥ 1 cancer cell in blood sample) or absence (-ve) of CTCs on patient outcome. Figure S8. Impact of the presence (+ve, EFC#93 pattern frequency ≥ 0.00008) or absence (-ve) of serum DNA methylation in CTC + ve (≥1 cancer cell in pre-chemotherapy blood sample) or absence CTC-ve patients. Figure S9. Relapse-free and overall survival according to samples taken after chemotherapy. Figure S10. Relapse-free and overall survival according to samples taken after chemotherapy. Figure S11. Average serum DNA amount correlates with average UK temperature. Figure S12. Average serum DNA fragment size correlates with average UK temperature. Figure S13. Correlation of DNA fragment size and DNA amount. Figure S14. Overall survival of women whose samples were taken before and after chemotherapy and before anti-hormonal treatment in hormone receptor-negative and -positive SUCCESS participants. Figure S15. Overall survival of women whose samples were taken before and after chemotherapy and before anti-hormonal treatment in hormone receptor-negative and -positive SUCCESS participants. (PDF 2123 kb)
Poloxamer sols endowed with in-situ gelability and mucoadhesion by adding hypromellose and hyaluronan for prolonging corneal retention and drug delivery
Creators: name: Chen, Ling-Chun
name: Lin, Shyr-Yi
name: Cheng, Wei-Jie
name: Sheu, Ming-Thau
name: Chung, Chi-Yun
name: Hsu, Chen-Hsuan
name: Lin, Hong-Liang
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biochemistry
Space Science
Medicine
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: The purpose of this study was to develop poloxamer (P407)-based in-situ thermogellable hydrogels with reducing concentration of P407 by adding hypromellose (HPMC) and with enhancing mucoadhesion of resulting hydrogels by adding hyaluronic acid (HA) for prolonging ocular delivery of hydroxypropyl-β-cyclodextrin (HPβCD)-solubilized testosterone (TES). Results demonstrated that 0.5% TES solution was successfully solubilized with adding 10% HPβCD. Non-gellable 13% P407 sol became in-situ gellable with adding 2.0-2.5% HPMC and mucoadhesibility was further imporved with adding 0.3% HA-L (low MW) or HA-H (high MW). Optimized 0.5% HPβCD-solubilized TES P407-based thermogellable hydrogels with enhancement of mucoadhesion for prolonging ocular delivery comprised 13% P407, 2.5% HPMC, and 0.3% HA-L or HA-H. Furthermore, rheological measurements under simulated eye blinking confirmed that non-thixotropic properties of optimized hydrogels could be spreaded evenly and retain a greater amount of drug-loaded hydrogels on the ocular surface for a longer period to prolong drug delivery. Compared with conventional eye drops, the prolonged residence time of optimized hydrogels from ex vivo and in vivo studies were observed, indicating relationships between rheological properties and in vivo performances. It was concluded that P407-based thermosensitive hydrogels with reducing concentration of P407 and enhancing mucoadhesion was successfully formulated by adding 2.5% HPMC and 0.3% HA in 13% P407 for potentially accomplishing effective clinical treatment of DED.
Resonant x-ray scattering reveals possible disappearance of magnetic order under hydrostatic pressure in the Kitaev candidate $γ$-Li$_2$IrO$_3$
Creators: name: Breznay, Nicholas P.
name: Ruiz, Alejandro
name: Frano, Alex
name: Bi, Wenli
name: Birgeneau, Robert J.
name: Haskel, Daniel
name: Analytis, James G.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Honeycomb iridates such as $γ$-Li$_2$IrO$_3$ are argued to realize Kitaev spin-anisotropic magnetic exchange, along with Heisenberg and possibly other couplings. While systems with pure Kitaev interactions are candidates to realize a quantum spin liquid ground state, in $γ$-Li$_2$IrO$_3$ it has been shown that the balance of magnetic interactions leads to the incommensurate spiral spin order at ambient pressure below 38 K. We study the fragility of this state in single crystals of $γ$-Li$_2$IrO$_3$ using resonant x-ray scattering (RXS) under applied hydrostatic pressures of up to 3.0 GPa. RXS is a direct probe of the underlying electronic order, and we observe the abrupt disappearance of the $q$=(0.57, 0, 0) spiral order at a critical pressure $P_c = 1.5\ $GPa with no accompanying change in the symmetry of the lattice. This dramatic disappearance is in stark contrast with recent studies of $β$-Li$_2$IrO$_3$ that show continuous suppression of the spiral order in magnetic field; under pressure, a new and possibly nonmagnetic ground state emerges.
Branes and the vacuum structure of supersymmetric gauge theories
Creators: name: Cabrera Marquez, Santiago
Publisher: name: Imperial College London
Year: 2019

description: The study of quantum field theories and supersymmetric quantum field theories has thrived in the recent decades. An aspect of this study has a particularly geometrical nature and as such has also started to spearhead progress in related fields of mathematics. This aspect is the study of vacua. Traditional computations in quantum field theory understand particle states as perturbations around a vacuum state. Many theories have a plethora of candidates to be this vacuum state. Different choices of vacuum imply different properties of the particles in the theory. These physical differences can be understood by creating a moduli space: an affine variety in which each point of the variety corresponds to a different vacuum of the theory. The physical properties of the vacua are then realized as geometrical properties of the different points in the variety. In this thesis we analyse these properties and develop new techniques to further their study: the Kraft-Procesi transition and the magnetic quivers. In order to do so we employ a particular fruitful approach to this type of problems: embedding the quantum field theories at hand in a string theoretical background. By this procedure, the low energy dynamics of branes in the string theory set up correspond to motions along the moduli space of vacua of the theory. The new results that we present here aim to be a set of tools that can readily be applied to the analysis of many different supersymmetric quantum field theories. The goal is that the tools are based on manipulations of simple diagrams, which should make them easy to remember and easy to implement.
Additional file 2 of Recombinant annexin A2 inhibits peripheral leukocyte activation and brain infiltration after traumatic brain injury
Creators: name: Liu, Ning
name: Han, Jinrui
name: Li, Yadan
name: Jiang, Yinghua
name: Shi, Samuel X.
name: Lok, Josephine
name: Whalen, Michael
name: Dumont, Aaron S.
name: Wang, Xiaoying
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2: Supplemental Figure 2. Effect of rA2 on monocytes and T lymphocytes in blood after TBI. (A) Representative gating strategy of peripheral monocytes (CD11b+ Ly6C+), T lymphocytes (CD3+) from single-cell suspensions, and the expression of IL-6, TNF-α, IL-10 in monocytes, and the expression of IL-6, TNF-α, CD69 in T lymphocytes. All gates were set using FMO controls. (B,D) Counts of peripheral monocytes (B) and T lymphocytes (D) of Sham, TBI, and TBI + rA2 mice at 24 h after TBI, n = 6–8. (C) Quantitative analysis shows the expression of IL-6, TNF-α, and IL-10 in monocytes, n = 4–6. (E) Quantitative analysis shows the expression of IL-6, TNF-α, and CD69 in T lymphocytes, n = 4–6. Data are expressed as mean ± SEM, * p < 0.05 compared to sham, # p < 0.05 compared to TBI.
In vitro comparative study of multimodal imaging nano-assembled microspheres with two clinical drug-eluting beads loaded with doxorubicin
Creators: name: He, Yiwei
name: Xu, Tiancheng
name: Ding, Tingting
name: Gong, Yuanchuan
name: Zeng, Hui
name: Xi, Zihan
name: Ye, Yuanxin
name: Song, Ziyang
name: Pan, Ting
name: Zhang, Zhewei
name: Ma, Qian
name: Li, Lihua
name: Zhang, Yuqing
name: Shao, Guoliang
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Space Science
Medicine
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Cancer

description: DC Beads and CalliSpheres are commonly used microspheres in clinical transcatheter arterial chemoembolization, but these microspheres cannot be visualized by themselves. Therefore, in our previous study, we developed multimodal imaging nano-assembled microspheres (NAMs), which are visualized under CT/MR and the location of embolic microspheres can be determined during postoperative review, facilitating the evaluation of embolic areas and guiding subsequent treatment. Moreover, the NAMs can be carried with positively and negatively charged drugs, increasing the choice of drugs. Systematic comparative analysis of the pharmacokinetics of NAMs with commercially available DC Bead and CalliSpheres microspheres is important for evaluating the clinical application of NAMs. In our study, we compared the similarities and differences between NAMs and two drug-eluting beads (DEBs) in respect to drug loading capacity, drug release profiles, diameter variation and morphological characteristics. The results indicate that NAMs had good drug delivery and release characteristics as well as DC Bead and CalliSpheres in vitro experimental stage. Therefore, NAMs have a good application prospect in transcatheter arterial chemoembolization treatment of hepatocellular carcinoma.
MOESM1 of Elucidating adolescent aspirational models for the design of public mental health interventions: a mixed-method study in rural Nepal
Creators: name: Sauharda Rai
name: Safar Adhikari
name: Acharya, Nanda
name: Kaiser, Bonnie
name: Kohrt, Brandon
Publisher: name: figshare
Year: 2017
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy

description: Additional file 1. Examples of coding queries exported from Nvivo 11.
Generative Adversarial Networks recover features in astrophysical images of galaxies beyond the deconvolution limit
Creators: name: Schawinski, Kevin
name: Zhang, Ce
name: Zhang, Hantian
name: Fowler, Lucas
name: Santhanam, Gokula Krishnan
Publisher: name: arXiv
Year: 2017
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Observations of astrophysical objects such as galaxies are limited by various sources of random and systematic noise from the sky background, the optical system of the telescope and the detector used to record the data. Conventional deconvolution techniques are limited in their ability to recover features in imaging data by the Shannon-Nyquist sampling theorem. Here we train a generative adversarial network (GAN) on a sample of $4,550$ images of nearby galaxies at $0.01
description: Accepted for publication in MNRAS, for the full code and a virtual machine set up to run it, see http://space.ml/proj/GalaxyGAN.html
SARS-CoV-2 mutations and where to find them: an in silico perspective of structural changes and antigenicity of the spike protein
Creators: name: Gonçalves, Ricardo Lemes
name: Leite, Túlio César Rodrigues
name: de Paula Dias, Bruna
name: da Silva Caetano, Camila Carla
name: de Souza, Ana Clara Gomes
name: da Silva Batista, Ubiratan
name: Barbosa, Camila Cavadas
name: Reyes-Sandoval, Arturo
name: Coelho, Luiz Felipe Leomil
name: de Mello Silva, Breno
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 60506 Virology

description: Communicated by Ramaswamy H. Sarma
title: ADCO, Ordre cistercien et abbaye de Cîteaux : comptes pour l'ordre (1337-1347), comptes du boursier (1377-1402) (11 H 1160), f. 00411
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2017
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Chartes de la Bourgogne du Moyen Âge
subject: comptes
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi

description: Ordre cistercien et abbaye de Cîteaux : comptes pour l'ordre (1337-1347), comptes du boursier (1377-1402), Archives départementales de la Côte-d'Or, (11 H 1160). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Ordre cistercien et abbaye de Cîteaux : comptes pour l'ordre (1337-1347), comptes du boursier (1377-1402), Archives départementales de la Côte-d'Or, (11 H 1160), f. 00411, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Ultra-light and strong: the massless harmonic oscillator and its singular path integral
Creators: name: Modanese, G.
Publisher: name: arXiv
Year: 2017
Subjects: subject: General Physics (physics.gen-ph)
subject: FOS: Physical sciences

description: In classical mechanics, a light particle bound by a strong elastic force just oscillates at high frequency in the region allowed by its initial position and velocity. In quantum mechanics, instead, the ground state of the particle becomes completely de-localized in the limit $m \to 0$. The harmonic oscillator thus ceases to be a useful microscopic physical model in the limit $m \to 0$, but its Feynman path integral has interesting singularities which make it a prototype of other systems exhibiting a "quantum runaway" from the classical configurations near the minimum of the action. The probability density of the coherent runaway modes can be obtained as the solution of a Fokker-Planck equation associated to the condition $S=S_{min}$. This technique can be applied also to other systems, notably to a dimensional reduction of the Einstein-Hilbert action.
title: ADCO, Grènetier de Cîteaux : comptes (1497-1504) (11 H 1172), f. 00485
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: comptes
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172), f. 00485, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
MOESM4 of The malaria testing and treatment landscape in Kenya: results from a nationally representative survey among the public and private sector in 2016
Creators: name: Musuva, Anne
name: Waqo Ejersa
name: Kiptui, Rebecca
name: Memusi, Dorothy
name: Abwao, Edward
Publisher: name: figshare
Year: 2017
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Computational Biology

description: Additional file 4. Proportion of providers who report an ACT was the most effective anti-malarial medicine for a child.
Supplement Table S3
Creators: name: Lyu, Houchen
name: Zhao, Sizheng
name: Li, Jiatian
name: Li, Xiaoxiao
name: Wang, Yilun
name: Xie, Dongxing
name: Zeng, Chao
name: Lei, Guanghua
name: Wei, Jie
name: Li, Hui
Publisher: name: figshare
Year: 2022
Subjects: subject: 110306 Endocrinology
subject: FOS: Clinical medicine

description: Supplement Table S3
Additional file 3 of Recombinant annexin A2 inhibits peripheral leukocyte activation and brain infiltration after traumatic brain injury
Creators: name: Liu, Ning
name: Han, Jinrui
name: Li, Yadan
name: Jiang, Yinghua
name: Shi, Samuel X.
name: Lok, Josephine
name: Whalen, Michael
name: Dumont, Aaron S.
name: Wang, Xiaoying
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 3: Supplemental Figure 3. Effect of rA2 on the activation of microglia, macrophage and T lymphocytes in the mouse brain. (A) Representative gating strategy for the expression of CD86, IL-6, TNF-α in microglia (CD11b+CD45int) and macrophages (CD11b+ CD45high F4/80+), and the expression of CD69, IL-6, TNF-α in T lymphocytes (CD45+ CD3+), the brain tissues obtained at 24 h after TBI from Sham, TBI, and TBI + rA2 mice. All gates were set using FMO controls. (B) Cell counts of microglia expressing CD86, IL-6, and TNF-α in the brain, and cell counts of macrophage expressing CD86, IL-6, and TNF-α in the brain, and cell counts of T lymphocyte expressing CD69, IL-6, and TNF-α in brains, n = 4–8. (C) Flow cytometry plots show the expression of TLR4 and TLR2 in brain infiltrated neutrophils, macrophages, and T lymphocytes obtained from brain tissues of TBI at 24 h. (D) Quantitation of TLR4 and TLR2 expressing in brain infiltrated neutrophils, macrophages, and T lymphocytes of Sham, TBI, and TBI + rA2 mice, n = 4. Data are expressed as mean ± SEM, * p < 0.05 compared to Sham, # p < 0.05 compared to TBI.
Dynamic defects in photonic Floquet topological insulators
Creators: name: Jörg, Christina
name: Letscher, Fabian
name: Fleischhauer, Michael
name: von Freymann, Georg
Publisher: name: arXiv
Year: 2017
Subjects: subject: Optics (physics.optics)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Edge modes in topological insulators are known to be robust against defects. We investigate if this also holds true when the defect is not static, but varies in time. We study the influence of defects with time-dependent coupling on the robustness of the transport along the edge in a Floquet system of helically curved waveguides. Waveguide arrays are fabricated via direct laser writing in a negative tone photoresist. We find that single dynamic defects do not destroy the chiral edge current, even when the temporal modulation is strong. Quantitative numerical simulation of the intensity in the bulk and edge waveguides confirms our observation.
The cell type dependent sorting of CD9- and CD81 to extracellular vesicles can be exploited to convey tumor sensitive cargo to target cells
Creators: name: Zuppone, Stefania
name: Zarovni, Natasa
name: Vago, Riccardo
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Extracellular vesicles (EVs) are lipid membrane-bound particles involved in cell-to-cell communication through a delivery of regulatory molecules essential for physiological processes. Since EVs efficiently vectorize specific cargo molecules, they have been proposed as suitable vehicles for therapeutic agents. Drug loading into EVs can be achieved by active, exogenous strategies or by genetic modifications of vesicle-producing cells. With the aim to produce EVs conveying therapeutic proteins, we genetically engineered and compared HEK293 to tumor cells. Tetraspanin-based RFP fusions were found to be more stable and preferentially sorted into EVs in HEK293. EVs isolated from genetically modified HEK293 cells media were captured by cancer cells, efficiently delivering their cargo. Cathepsin B cleavage site introduced between CD9/CD81 and RFP was recognized by tumor specific proteases allowing the release of the reporter protein. Our results indicate HEK293 cells as a preferential system for the production of EVs and pave the way to the development of nano-platforms for the efficient delivery of therapeutic proteins and prodrugs to tumor cells.
Supplement Figure S1
Creators: name: Lyu, Houchen
name: Zhao, Sizheng
name: Li, Jiatian
name: Li, Xiaoxiao
name: Wang, Yilun
name: Xie, Dongxing
name: Zeng, Chao
name: Lei, Guanghua
name: Wei, Jie
name: Li, Hui
Publisher: name: figshare
Year: 2022
Subjects: subject: 110306 Endocrinology
subject: FOS: Clinical medicine

description: Supplement Figure S1
MOESM3 of The malaria testing and treatment landscape in Kenya: results from a nationally representative survey among the public and private sector in 2016
Creators: name: Musuva, Anne
name: Waqo Ejersa
name: Kiptui, Rebecca
name: Memusi, Dorothy
name: Abwao, Edward
Publisher: name: figshare
Year: 2017
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Computational Biology

description: Additional file 3. Availability of QAACT among anti-malarial stocking outlets, by strata.
Deep-HiTS: Rotation Invariant Convolutional Neural Network for Transient Detection
Creators: name: Cabrera-Vives, Guillermo
name: Reyes, Ignacio
name: Förster, Francisco
name: Estévez, Pablo A.
name: Maureira, Juan-Carlos
Publisher: name: arXiv
Year: 2017
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: We introduce Deep-HiTS, a rotation invariant convolutional neural network (CNN) model for classifying images of transients candidates into artifacts or real sources for the High cadence Transient Survey (HiTS). CNNs have the advantage of learning the features automatically from the data while achieving high performance. We compare our CNN model against a feature engineering approach using random forests (RF). We show that our CNN significantly outperforms the RF model reducing the error by almost half. Furthermore, for a fixed number of approximately 2,000 allowed false transient candidates per night we are able to reduce the miss-classified real transients by approximately 1/5. To the best of our knowledge, this is the first time CNNs have been used to detect astronomical transient events. Our approach will be very useful when processing images from next generation instruments such as the Large Synoptic Survey Telescope (LSST). We have made all our code and data available to the community for the sake of allowing further developments and comparisons at https://github.com/guille-c/Deep-HiTS.
The Maximally Symmetric Composite Higgs
Creators: name: Csaki, Csaba
name: Ma, Teng
name: Shu, Jing
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We present a novel class of calculable four dimensional composite pseudo-Goldstone boson Higgs models based on symmetric G/H coset spaces which contain a Higgs-parity operator V as well as a linear representation $Σ'$ for the Goldstone bosons. For such cosets the low-energy effective Lagrangian for the Standard Model fields can have an enhanced global symmetry which we call the maximal symmetry. We show that such a maximally symmetric case leads to a finite and fully calculable Higgs potential, which also minimizes the tuning by eliminating double tuning and reducing the Higgs mass. We present a detailed analysis of the Maximally Symmetric SO(5)/SO(4) model, and comment on its observational consequences.
description: 11 pages, LaTeX, 4 figures
MOESM2 of The malaria testing and treatment landscape in Kenya: results from a nationally representative survey among the public and private sector in 2016
Creators: name: Musuva, Anne
name: Waqo Ejersa
name: Kiptui, Rebecca
name: Memusi, Dorothy
name: Abwao, Edward
Publisher: name: figshare
Year: 2017
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Marine Biology
subject: 60506 Virology
subject: Computational Biology

description: Additional file 2. Availability of QA AL, among all screened public sector outlets.
Phytic acid-modified manganese dioxide nanoparticles oligomer for magnetic resonance imaging and targeting therapy of osteosarcoma
Creators: name: Ju, Qian
name: Huang, Rong
name: Hu, Ruimin
name: Fan, Junjie
name: Zhang, Dinglin
name: Ding, Jun
name: Li, Rong
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: Osteosarcoma is the most common malignant tumor in the skeletal system with high mortality. Phytic acid (PA) is a natural compound extracted from plant seeds, which shows certain antitumor activity and good bone targeting ability. To develop a novel theranostics for magnetic resonance imaging (MRI) and targeting therapy of osteosarcoma, we employed PA to modify manganese dioxide nanoparticles (MnO2@PA NPs) for osteosarcoma treatment. The MnO2 NPs oligomer was formed by PA modification with uniformed size distribution and negative zeta potential. Fourier-transform infrared spectroscopy, X-ray diffraction, energy dispersive spectroscopy, X-ray photoelectron spectroscopy, and thermogravimetric analysis demonstrated that PA has been successfully modified on MnO2 NPs, and the structure of MnO2@PA NPs is amorphous. In vitro experiments demonstrated that MnO2@PA NPs oligomer can be efficiently internalized by tumor cell, and the internalized NPs can react with H2O2 under acid microenvironment to produce Mn2+ and O2. In vivo experiments demonstrated that MnO2@PA NPs oligomer can passively accumulate in tumor tissue, and the accumulated NPs can produce Mn2+ and O2 for MRI and targeting therapy of osteosarcoma. In conclusion, we prepared a novel bone-targeting nano theranostics for MRI and therapy of osteosarcoma.
Identification of barriers and enablers to rapid diagnosis along the paediatric stroke chain of recovery using Value-Focused Process Engineering
Creators: name: Mackay, Mark T.
name: Churilov, Leonid
name: Moon, Anna
name: McKenzie, Ian
name: Donnan, Geoffrey A.
name: Monagle, Paul
name: Li, Qi
name: Babl, Franz E.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: Medicine
Neuroscience
Environmental Sciences not elsewhere classified
Information Systems not elsewhere classified
Computational Biology

description: Coordinated systems of care are required to improve access to reperfusion therapies in paediatric stroke. A conceptual model was developed to map the process-of-care from symptom onset to confirmation of diagnosis. Value-Focused Process Engineering with event-driven process modelling was used to identify barriers and enablers to timely and accurate paediatric stroke diagnosis. Stakeholder interviews were conducted to inform model design, development, demonstration and validation. Barriers included: (i) ambulance dispatcher failure to allocate high-priority response, (ii) childrens’ exclusion from paramedic clinical practice guidelines, (ii) non-allocation of high triage category on hospital arrival, (iii) absence of emergency department guidelines for focal neurological deficits, and (iv) computed tomography as the first imaging investigation. Enablers included: (i) public awareness programs, (ii) childrens’ inclusion in prehospital emergency stroke algorithms, (iii) re-organisation of health services, with primary paediatric stroke centres, (iv) implementation of triage and neuroimaging decision support tools, and (iv) rapid stroke MRI imaging protocols.
The development and evaluation of hyaluronic acid coated mitochondrial targeting liposomes for celastrol delivery
Creators: name: Xiao, Simeng
name: Huang, Siying
name: Yang, Xiaojing
name: Lei, Yujie
name: Chang, Mingxiang
name: Hu, Junjie
name: Meng, Yan
name: Zheng, Guohua
name: Chen, Xinyan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: Science Policy

description: In order to precisely deliver celastrol into mitochondria of tumor cells, improve antitumor efficacy of celastrol and overcome its troublesome problems in clinical application, a novel multistage-targeted celastrol delivery system (C-TL/HA) was developed via electrostatic binding of hyaluronic acid (HA) to celastrol-loaded cationic liposomes composed of natural soybean phosphatidylcholine and cholesterol modified with mitochondrial targeting molecular TPP. Study results in this article showed that C-TL/HA successfully transported celastrol into mitochondria, effectively activated apoptosis of mitochondrial pathway, exerted higher tumor inhibition efficiency and lower toxic side effects compared with free celastrol. More importantly, HA coating not only enabled this delivery system to have good stability and safety in vivo, but also increased drug uptake and facilitated tumor targeting through recognizing CD44 receptors rich on the surface of tumor cells. Conclusively, this HA-coated mitochondrial targeting liposomes may provide a prospect for the clinical application of celastrol in tumor therapy.
Strength and toughness in spiculate tempered pottery dataset
Creators: name: Lawres, Nathan
name: Collins, David
name: Ware, Megan
name: Dees, Jessica
Year: 2022
Subjects: subject: Ceramic
valueUri: https://core.tdar.org/browse/material-type/1/ceramic
subject: experimental archaeology, sponge spicule tempered pottery
valueUri: https://core.tdar.org/browse/material-type/3398/experimental-archaeology-sponge-spicule-tempered-pottery
subject: Experimental Archaeology
valueUri: https://core.tdar.org/browse/other-keyword/27029/experimental-archaeology

description: This dataset includes information related to a series of experimental ceramic assemblages created to test the relationship between temper type and the performance characteristics of strength and toughness. Three temper groups were created: untempered, sand-tempered, and fused silica (as a proxy for siliceous sponge spicules) tempered. Each temper group was divided into to firing temperatures: 500C and 700C. All samples were subjected to testing with a Mark-10 ESM303 motorized test stand equipped with an M5-300 force gauge and three-point bend apparatus.