New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Creators: name: Loos, Ruth J. F.
name: Kanoni, Stavroula
name: Fatemifar, Ghazaleh
name: Laatikainen, Tiina
name: Menni, Cristina
name: Lu, Yingchang
name: Vinkhuyzen, Anna A. E.
name: Blüher, Matthias
name: Mägi, Reedik
name: Harris, Tamara B.
name: Ahluwalia, Tarunveer Singh
name: Cederholm, Tommy
name: Leach, Irene Mateo
name: Perry, John R. B.
name: Dehghan, Abbas
name: Luan, Jian'an
name: De Jager, Philip L.
name: Spector, Tim D.
name: Eriksson, Johan G.
name: Friedrich, Nele
name: Wareham, Nicholas J.
name: Hillege, Hans
name: Bishop, D. Timothy
name: McKenzie, Colin A.
name: Jula, Antti
name: Boehnke, Michael
name: Justice, Anne E.
name: Döring, Angela
name: Dhonukshe-Rutten, Rosalie A. M.
name: Spira, Dominik
name: Esko, Toñu
name: Rudan, Igor
name: Stumvoll, Michael
name: Loh, Marie
name: Palmer, Cameron D.
name: Czerwinski, Stefan A.
name: Fumeron, Frédéric
name: Vartiainen, Erkki
name: Bouchard, Claude
name: Forouhi, Nita G.
name: Kovacs, Peter
name: Liu, Tian
name: Bertram, Lars
name: Lichtner, Peter
name: Havulinna, Aki S.
name: Widén, Elisabeth
name: Sung, Yun Ju
name: Kähönen, Mika
name: Kumari, Meena
name: Choi, Hyung Jin
name: Knekt, Paul B.
name: Srikanth, Priya
name: Hansen, Torben
name: Lyytikaïnen, Leo-Pekka
name: Forrester, Terrence
name: Schadt, Eric E.
name: Van Der Velde, Nathalie
name: Zhu, Zhihong
name: Kiel, Douglas P.
name: Li, Xin
name: Orwoll, Eric S.
name: Langenberg, Claudia
name: Pérusse, Louis
name: Ohlsson, Claes
name: Franke, Lude
name: Buchkovich, Martin L.
name: Van Duijn, Cornelia M.
name: Naranäiä, Nina Smolej
name: Cho, Nam H.
name: Enneman, Anke W.
name: Viikari, Jorma S.
name: Vohl, Marie-Claude
name: Peters, Annette
name: Heliövaara, Markku
name: Cousminer, Diana L.
name: Vandenput, Liesbeth
name: Day, Felix R.
name: Eckardt, Rahel
name: Uitterlinden, André G.
name: Palotie, Aarno
name: Nielson, Carrie M.
name: Raitakari, Olli T.
name: Fox, Caroline
name: Bishop, Julia A. N.
name: Murabito, Joanne M.
name: Hysi, Pirro G.
name: Verweij, Niek
name: Rice, Treva K.
name: Michaëlsson, Karl
name: Sarzynski, Mark A.
name: Wright, Alan F.
name: Cupples, L. Adrienne
name: Kent, Jack W.
name: Luke, Amy
name: Karpe, Fredrik
name: Gansevoort, Ron T.
name: Lobbens, Stéphane
name: Männistö, Satu
name: Na, Jianbo
name: Blangero, John
name: Qi, Qibin
name: Schmidt, Ellen M.
name: Gärtner, Simone
name: Tayo, Bamidele O.
name: Yang, Jian
name: Campbell, Harry
name: Pers, Tune H.
name: Taittonen, Leena
name: Jackson, Anne U.
name: Oostra, Ben A.
name: Hayward, Caroline
name: Osmond, Clive
name: Han, Bok-Ghee
name: Tanaka, Toshiko
name: Swart, Karin M. A.
name: Morris, Andrew P.
name: Cooper, Richard S.
name: McCarthy, Mark I.
name: Wilson, James F.
name: Yengo, Loïc
name: Lind, Lars
name: Gustafsson, Stefan
name: Curran, Joanne E.
name: Zhang, Weihua
name: Boettcher, Yvonne
name: Salomaa, Veikko
name: Hunter, David J.
name: Wallaschofski, Henri
name: Bataille, Veronique
name: Strauch, Konstantin
name: Pospisilik, John Andrew
name: Zmuda, Joseph M.
name: Jørgensen, Torben
name: Tikkanen, Emmi
name: Kajantie, Eero
name: Rao, 
name: Karjalainen, Juha
name: Ried, Janina S.
name: Lehtimäki, Terho
name: Jousilahti, Pekka
name: Kooner, Jaspal S.
name: Ferreira, Teresa
name: Hingorani, Aroon
name: Oozageer, Laticia
name: Scott, William R.
name: Buchman, Aron S.
name: Kristiansson, Kati
name: Demuth, Ilja
name: Falchi, Mario
name: Bennett, David A.
name: Haring, Robin
name: Demirkan, Ayse
name: Walker, Ryan W.
name: Kivimaki, Mika
name: Borecki, Ingrid B.
name: Liu, Youfang
name: Choh, Audrey C.
name: Furey, Terrence S.
name: Koskinen, Seppo
name: Kuulasmaa, Teemu
name: Drong, Alexander W.
name: Li, Rui
name: Shuldiner, Alan R.
name: Kuusisto, Johanna
name: Sørensen, Thorkild I. A.
name: McKnight, Barbara
name: Rivadeneira, Fernando
name: Ingelsson, Erik
name: Hofman, Albert
name: Linneberg, Allan
name: Rankinen, Tuomo
name: Tönjes, Anke
name: North, Kari E.
name: O'Connell, Jeffrey R.
name: Hastie, Nicholas
name: Vollenweider, Peter
name: De Groot, Lisette C. P. G. M.
name: Paternoster, Lavinia
name: Mahajan, Anubha
name: Richards, J. Brent
name: Kaplan, Robert C.
name: Eklund, Niina
name: Gudnason, Vilmundur
name: Deloukas, Panos
name: Kühnel, Brigitte
name: Han, Jiali
name: Scott, Robert A.
name: Grarup, Niels
name: Garcia, Melissa E.
name: Nalls, Mike A.
name: Song, Kijoung
name: Lindgren, Cecilia
name: Wagner, Peter J.
name: Franco, Oscar H.
name: Perola, Markus
name: Evans, David M.
name: Evans, Daniel S.
name: Tranah, Gregory J.
name: Grallert, Harald
name: Iles, Mark M.
name: Westra, Harm-Jan
name: Dastani, Zari
name: Zhang, Mingfeng
name: Lee, Jong-Young
name: Vitart, Veronique
name: Kilpelaïnen, Tuomas Oskari
name: Wild, Sarah
name: Pascoe, Laura
name: Borodulin, Katja
name: Tremblay, Angelo
name: Hernandez, Dena
name: Lu, Chen
name: Chambers, John C.
name: Ong, Ken K.
name: Hedman, Åsa K.
name: Afzal, Uzma
name: Froguel, Philippe
name: Yu, Lei
name: Pedersen, Oluf
name: Zillikens, M. Carola
name: Bellis, Claire
name: Shungin, Dmitry
name: Liu, Yongmei
name: Shin, Chan Soo
name: Gieger, Christian
name: Forsen, Tom
name: Ferrucci, Luigi
name: Lee, Christine G.
name: Hirschhorn, Joel N.
name: Laakso, Markku
name: Prokopenko, Inga
name: Mohlke, Karen L.
name: Sanna, Marianna
name: Cummings, Steven R.
name: Stancáková, Alena
name: Medina-Gomez, Carolina
name: Eury, Elodie
name: Ripatti, Samuli
name: Feitosa, Mary F.
name: Van Schoor, Natasja M.
name: Walker, Mark
name: Bakker, Stephan J. L.
name: Van Der Harst, Pim
name: Locke, Adam
name: Lahti, Jari
name: Willer, Cristen J.
name: White, Charles C.
name: Jordan, Joanne M.
name: Steinhagen-Thiessen, Elisabeth
name: Kolcic, Ivana
name: Mangino, Massimo
name: Towne, Bradford
name: Bonnefond, Amélie
name: Zhao, Jing Hua
name: Polašek, Ozren
name: Ittermann, Till
name: Völzke, Henry
name: Lagou, Vasiliki
name: Teumer, Alexander
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10−8), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.