title: ÐÐ¾Ð½ÑÐ°ÐºÑÐ½Ð¾Ðµ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ ÐºÑÐ¾Ð²Ð¸ ÑÐµÐ»Ð¾Ð²ÐµÐºÐ° Ñ Ð³ÐµÐ¼Ð¾ÑÐ¾ÑÐ±ÐµÐ½ÑÐ°Ð¼Ð¸ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ ÑÐ¸Ð»Ð¸ÐºÐ°Ð³ÐµÐ»ÐµÐ¹ Ð¸ Ñ Ð¸ÑÐ¾Ð·Ð°Ð½Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Contact interaction of human blood with hemosorbents based on silica and chitosan
Creators: name: ÐÐ¸ÑÐ¸ÑÑÐº, ÐÐºÑÐ°Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: Ð¼Ð°Ð»Ð¾Ð¾Ð±ÑÐµÐ¼Ð½Ð°Ñ Ð³ÐµÐ¼Ð¾Ð¿ÐµÑÑÑÐ·Ð¸Ñ
ÐºÐ¾Ð½ÑÐ°ÐºÑÐ½Ð°Ñ Ð°ÐºÑÐ¸Ð²Ð°ÑÐ¸Ñ ÐºÑÐ¾Ð²Ð¸
Ð³ÐµÐ¼Ð¾ÑÐ¾ÑÐ±ÐµÐ½ÑÑ
ÑÐ¸Ð»Ð¸ÐºÐ°Ð³ÐµÐ»Ñ
Ñ Ð¸ÑÐ¾Ð·Ð°Ð½
Ð³ÐµÐ¼Ð¾Ð»Ð¸Ð·
Ð³ÐµÐ¼Ð¾ÑÐ¾Ð²Ð¼ÐµÑÑÐ¸Ð¼Ð¾ÑÑÑ
low-volume hemoperfusion
contact activation of blood
hemosorbents
silica
chitosan
hemocompatibility
hemolysis

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description: The activation potential and hemocompatibility of sorbents on a base of Silochrom S-120 and chitosan were studied in this work. The experiments were carried out in vitro using a donorâs venous blood. The adhesion of platelets, leukocytes and their subpopulations (granulocytes and agranulocytes) was evaluated. Hemocompatibility was evaluated by the degree of hemolysis of red blood cells using spectrophotometry of blood plasma. During the contact of blood with each of the studied sorbents, the adhesion of cells to the surface of sorbents of varying intensity was observed. The best activation characteristics in the Silochrom group were observed on the CSCF sorbent, in the chitosan group - on the 0% CNF sorbent. Most of the sorbents of the Silochrom group cause intensive hemolysis of red blood cells during the contact with blood. The best hemocompatibility in this group was shown by the CSCF sorbent. In the chitosan group, all the studied sorbents showed sorption rather than the hemolytic effect on blood cells. All types of sorbents based on chitosan fibers are well hemocompatible. Comparing to the reference Carbon sorbent, CSCF has a significantly better activation potential and its hemocompatibility is close to the reference sorbent during the first 5 minutes of the experiment. The activation characteristics of the 0% CNF sorbent are close to that of Carbon, however, the hemocompatibility of chitosan fibers is much better than that of the reference hemosorbent throughout the entire experiment.