SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion
Creators: name: Mlcochova, Petra
name: Kemp, Steven A.
name: Dhar, Mahesh Shanker
name: Papa, Guido
name: Meng, Bo
name: Ferreira, Isabella A. T. M.
name: Datir, Rawlings
name: Collier, Dami A.
name: Albecka, Anna
name: Singh, Sujeet
name: Pandey, Rajesh
name: Brown, Jonathan
name: Zhou, Jie
name: Goonawardane, Niluka
name: Mishra, Swapnil
name: Whittaker, Charles
name: Mellan, Thomas
name: Marwal, Robin
name: Datta, Meena
name: Sengupta, Shantanu
name: Ponnusamy, Kalaiarasan
name: Radhakrishnan, Venkatraman Srinivasan
name: Abdullahi, Adam
name: Charles, Oscar
name: Chattopadhyay, Partha
name: Devi, Priti
name: Caputo, Daniela
name: Peacock, Tom
name: Wattal, Chand
name: Goel, Neeraj
name: Satwik, Ambrish
name: Vaishya, Raju
name: Agarwal, Meenakshi
name: Mavousian, Antranik
name: Lee, Joo Hyeon
name: Bassi, Jessica
name: Silacci-Fegni, Chiara
name: Saliba, Christian
name: Pinto, Dora
name: Irie, Takashi
name: Yoshida, Isao
name: Hamilton, William L.
name: Sato, Kei
name: Bhatt, Samir
name: Flaxman, Seth
name: James, Leo C.
name: Corti, Davide
name: Piccoli, Luca
name: Barclay, Wendy S.
name: Rakshit, Partha
name: Agrawal, Anurag
name: Gupta, Ravindra K.
name: Chauhan, Himanshu
name: Dikid, Tanzin
name: Gogia, Hema
name: Lall, Hemlata
name: Verma, Kaptan
name: Singh, Manoj K.
name: Soni, Namita
name: Meena, Namonarayan
name: Madan, Preeti
name: Singh, Priyanka
name: Sharma, Ramesh
name: Sharma, Rajeev
name: Kabra, Sandhya
name: Kumar, Sattender
name: Kumari, Swati
name: Sharma, Uma
name: Chaudhary, Urmila
name: Sivasubbu, Sridhar
name: Scaria, Vinod
name: Oberoi, J. K.
name: Raveendran, Reena
name: Datta, S.
name: Das, Saumitra
name: Maitra, Arindam
name: Chinnaswamy, Sreedhar
name: Biswas, Nidhan Kumar
name: Parida, Ajay
name: Raghav, Sunil K.
name: Prasad, Punit
name: Sarin, Apurva
name: Mayor, Satyajit
name: Ramakrishnan, Uma
name: Palakodeti, Dasaradhi
name: Seshasayee, Aswin Sai Narain
name: Thangaraj, K.
name: Bashyam, Murali Dharan
name: Dalal, Ashwin
name: Bhat, Manoj
name: Shouche, Yogesh
name: Pillai, Ajay
name: Abraham, Priya
name: Potdar, Varsha Atul
name: Cherian, Sarah S.
name: Desai, Anita Sudhir
name: Pattabiraman, Chitra
name: Manjunatha, M. V.
name: Mani, Reeta S.
name: Udupi, Gautam Arunachal
name: Nandicoori, Vinay
name: Tallapaka, Karthik Bharadwaj
name: Sowpati, Divya Tej
name: Kawabata, Ryoko
name: Morizako, Nanami
name: Sadamasu, Kenji
name: Asakura, Hiroyuki
name: Nagashima, Mami
name: Yoshimura, Kazuhisa
name: Ito, Jumpei
name: Kimura, Izumi
name: Uriu, Keiya
name: Kosugi, Yusuke
name: Suganami, Mai
name: Oide, Akiko
name: Yokoyama, Miyabishara
name: Chiba, Mika
name: Saito, Akatsuki
name: Butlertanaka, Erika P.
name: Tanaka, Yuri L.
name: Ikeda, Terumasa
name: Motozono, Chihiro
name: Nasser, Hesham
name: Shimizu, Ryo
name: Yuan, Yue
name: Kitazato, Kazuko
name: Hasebe, Haruyo
name: Nakagawa, So
name: Wu, Jiaqi
name: Takahashi, Miyoko
name: Fukuhara, Takasuke
name: Shimizu, Kenta
name: Tsushima, Kana
name: Kubo, Haruko
name: Shirakawa, Kotaro
name: Kazuma, Yasuhiro
name: Nomura, Ryosuke
name: Horisawa, Yoshihito
name: Takaori-Kondo, Akifumi
name: Tokunaga, Kenzo
name: Ozono, Seiya
name: Baker, Stephen
name: Dougan, Gordon
name: Hess, Christoph
name: Kingston, Nathalie
name: Lehner, Paul J.
name: Lyons, Paul A.
name: Matheson, Nicholas J.
name: Owehand, Willem H.
name: Saunders, Caroline
name: Summers, Charlotte
name: Thaventhiran, James E. D.
name: Toshner, Mark
name: Weekes, Michael P.
name: Maxwell, Patrick
name: Shaw, Ashley
name: Bucke, Ashlea
name: Calder, Jo
name: Canna, Laura
name: Domingo, Jason
name: Elmer, Anne
name: Fuller, Stewart
name: Harris, Julie
name: Hewitt, Sarah
name: Kennet, Jane
name: Jose, Sherly
name: Kourampa, Jenny
name: Meadows, Anne
name: O’Brien, Criona
name: Price, Jane
name: Publico, Cherry
name: Rastall, Rebecca
name: Ribeiro, Carla
name: Rowlands, Jane
name: Ruffolo, Valentina
name: Tordesillas, Hugo
name: Bullman, Ben
name: Dunmore, Benjamin J.
name: Fawke, Stuart
name: Gräf, Stefan
name: Hodgson, Josh
name: Huang, Christopher
name: Hunter, Kelvin
name: Jones, Emma
name: Legchenko, Ekaterina
name: Matara, Cecilia
name: Martin, Jennifer
name: Mescia, Federica
name: O’Donnell, Ciara
name: Pointon, Linda
name: Pond, Nicole
name: Shih, Joy
name: Sutcliffe, Rachel
name: Tilly, Tobias
name: Treacy, Carmen
name: Tong, Zhen
name: Wood, Jennifer
name: Wylot, Marta
name: Bergamaschi, Laura
name: Betancourt, Ariana
name: Bower, Georgie
name: Cossetti, Chiara
name: De Sa, Aloka
name: Epping, Madeline
name: Gleadall, Nick
name: Grenfell, Richard
name: Hinch, Andrew
name: Huhn, Oisin
name: Jackson, Sarah
name: Jarvis, Isobel
name: Krishna, Ben
name: Lewis, Daniel
name: Marsden, Joe
name: Nice, Francesca
name: Okecha, Georgina
name: Omarjee, Ommar
name: Perera, Marianne
name: Potts, Martin
name: Richoz, Nathan
name: Romashova, Veronika
name: Yarkoni, Natalia Savinykh
name: Sharma, Rahul
name: Stefanucci, Luca
name: Stephens, Jonathan
name: Strezlecki, Mateusz
name: Turner, Lori
name: De Bie, Eckart M. D. D.
name: Bunclark, Katherine
name: Josipovic, Masa
name: Mackay, Michael
name: Rossi, Sabrina
name: Selvan, Mayurun
name: Spencer, Sarah
name: Yong, Cissy
name: Allison, John
name: Butcher, Helen
name: Clapham-Riley, Debbie
name: Dewhurst, Eleanor
name: Furlong, Anita
name: Graves, Barbara
name: Gray, Jennifer
name: Ivers, Tasmin
name: Kasanicki, Mary
name: Le Gresley, Emma
name: Linger, Rachel
name: Meloy, Sarah
name: Muldoon, Francesca
name: Ovington, Nigel
name: Papadia, Sofia
name: Phelan, Isabel
name: Stark, Hannah
name: Stirrups, Kathleen E.
name: Townsend, Paul
name: Walker, Neil
name: Webster, Jennifer
name: Scholtes, Ingrid
name: Hein, Sabine
name: King, Rebecca
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Article
/631/250/254
/631/326/596/4130
/13/31
/13/100
article

description: Abstract: The B.1.617.2 (Delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in the state of Maharashtra in late 2020 and spread throughout India, outcompeting pre-existing lineages including B.1.617.1 (Kappa) and B.1.1.7 (Alpha)1. In vitro, B.1.617.2 is sixfold less sensitive to serum neutralizing antibodies from recovered individuals, and eightfold less sensitive to vaccine-elicited antibodies, compared with wild-type Wuhan-1 bearing D614G. Serum neutralizing titres against B.1.617.2 were lower in ChAdOx1 vaccinees than in BNT162b2 vaccinees. B.1.617.2 spike pseudotyped viruses exhibited compromised sensitivity to monoclonal antibodies to the receptor-binding domain and the amino-terminal domain. B.1.617.2 demonstrated higher replication efficiency than B.1.1.7 in both airway organoid and human airway epithelial systems, associated with B.1.617.2 spike being in a predominantly cleaved state compared with B.1.1.7 spike. The B.1.617.2 spike protein was able to mediate highly efficient syncytium formation that was less sensitive to inhibition by neutralizing antibody, compared with that of wild-type spike. We also observed that B.1.617.2 had higher replication and spike-mediated entry than B.1.617.1, potentially explaining the B.1.617.2 dominance. In an analysis of more than 130 SARS-CoV-2-infected health care workers across three centres in India during a period of mixed lineage circulation, we observed reduced ChAdOx1 vaccine effectiveness against B.1.617.2 relative to non-B.1.617.2, with the caveat of possible residual confounding. Compromised vaccine efficacy against the highly fit and immune-evasive B.1.617.2 Delta variant warrants continued infection control measures in the post-vaccination era.