Additional file 1 of Effects of glycemic traits on left ventricular structure and function: a mendelian randomization study
Creators: name: Ai, Sizhi
name: Wang, Xiaoyu
name: Wang, Shanshan
name: Zhao, Yilin
name: Guo, Shuxun
name: Li, Guohua
name: Chen, Zhigang
name: Lin, Fei
name: Guo, Sheng
name: Li, Yan
name: Zhang, Jihui
name: Zhao, Guoan
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Additional file 1: Method S1. The detailed procedure and sensitive analyses of the Multivariable MR analysis. Table S1. Insulin resistance-related SNPs associated with potential confounders. Table S6. Sensitivity MR analysis of the association between glycemic traits and left ventricular parameters. Table S7. Heterogeneity and horizontal pleiotropy test of the associations between glycemic traits and left ventricular parameters. Table S8. Additional MR analysis of the association between insulin resistance and left ventricular parameters. Table S9. Heterogeneity and horizontal pleiotropy test of the associations between insulin resistance and left ventricular parameters. Table S10. The bidirectional associations between insulin resistance and hemoglobin A1c. Table S11. Heterogeneity and horizontal pleiotropy text of the associations between insulin resistance and hemoglobin A1c. Table S12. Heterogeneity and horizontal pleiotropy text of the associations between insulin resistance, hemoglobin A1c and left ventricular parameters in multivariate MR Analyses. Table S13. Effects of insulin resistance and hemoglobin A1c on heart failure in univariable and multivariate MR Analyses. Table S14. Heterogeneity and horizontal pleiotropy text of the associations between insulin resistance, hemoglobin A1c and heart failure in univariable and multivariate MR Analyses. Figure S1. Scatterplots of the causal estimates of glycemic traits and left ventricular end-diastolic volume. Figure S2. Scatterplots of the causal estimates of glycemic traits and left ventricular end-systolic volume. Figure S3. Scatterplots of the causal estimates of glycemic traits and left ventricular ejection fraction. Figure S4. Scatterplots of the causal estimates of glycemic traits and left ventricular mass. Figure S5. Scatterplots of the causal estimates of glycemic traits and left ventricular mass to end-diastolic volume ratio. Figure S6. Leave-one-out analyses of the association between glycemic traits and left ventricular end-diastolic volume. Figure S7. Leave-one-out analyses of the association between glycemic traits and left ventricular end-systolic volume. Figure S8. Leave-one-out analyses of the association between glycemic traits and left ventricular ejection fraction. Figure S9. Leave-one-out analyses of the association between glycemic traits and left ventricular mass. Figure S10. Leave-one-out analyses of the association between glycemic traits and left ventricular mass to end-diastolic volume ratio. Figure S11. Scatterplots of the bidirectional association of IR and HbA1c. Figure S12. Leave-one-out analyses of the bidirectional association of IR and HbA1c. Figure S13. A brief schematic diagram of possible assumption of the association of IR and HbA1c with cardiac morphology.