The Somatic Genomic Landscape of Glioblastoma
Creators: name: Chin, Lynda
name: Pihl, Todd D.
name: Bose, Bikash
name: Liu, Yuexin
name: Eschbacher, Jennifer
name: Barnholtz-Sloan, Jill
name: Van Den Berg, Scott R.
name: Campos, Benito
name: Chen, Ken
name: Ljubimova, Julia Y.
name: Bootwalla, Moiz S.
name: Antipin, Yevgeniy
name: Kim, Jaegil
name: Iacocca, Mary
name: Chakravarty, Debyani
name: Xiao, Yonghong
name: Mills Shaw, Kenna R.
name: Sander, Chris
name: Jacobsen, Anders
name: Goldstein, Theodore
name: Brennan, Cameron W.
name: Zhang, Jianhua
name: Saksena, Gordon
name: Berens, Michael
name: Chen, Peng Chieh
name: Lander, Eric S.
name: Bressler, Ryan
name: Park, Peter J.
name: Scarpace, Lisa
name: Ardlie, Kristin
name: Benz, Christopher
name: Jing, Rui
name: Topal, Michael D.
name: Pollo, Bianca
name: Lai, Phillip H.
name: Salama, Sofie R.
name: Ciriello, Giovanni
name: Berman, Samuel H.
name: Craft, Brian
name: Protopopov, Alexei
name: Swanson, Patricia
name: Wu, Junyuan
name: Devi, Narra S.
name: Ayala, Brenda
name: Gabriel, Stacey
name: Saini, Marco
name: Lau, Ching
name: Rastogi, Pawan
name: Gao, Jianjiong
name: Yachnis, Anthony
name: Myers, Jerome
name: Goldman, Mary
name: Cohen, Mark L.
name: Mallery, David
name: Li, Ling
name: Schumacher, Steve
name: Shen, Ronglai
name: Fulton, Lucinda L.
name: Olson, Jeffrey J.
name: Weisenberger, Daniel J.
name: Aksoy, B. Arman
name: Curley, Erin
name: Tucker, Kelly
name: Black, Keith L.
name: Penny, Robert
name: Mallard, Will
name: O'Neill, Brian P.
name: Lin, Biaoyang
name: Leinonen, Kalle
name: Yung, W. K.
name: Shukla, Sachet A.
name: Devine, Karen
name: Zhang, Zhaobin
name: Beroukhim, Rameen
name: Lee, Semin
name: Zhu, Jing
name: Boulos, Madgy
name: Genovese, Giannicola
name: Davidsen, Tanja
name: Ma, Singer
name: Yalamanchii, Kennedy
name: Cerami, Ethan
name: Wilson, Richard
name: Kahn, Ari
name: Waltman, Peter
name: Pot, David A.
name: Schultz, Nikolaus
name: Guha, Abhijit
name: Carlin, Daniel
name: Cherniack, Andrew D.
name: Sanborn, J. Zachary
name: Bigner, Darell D.
name: Dillon, Laura A.L.
name: Ellrott, Kyle
name: Aldape, Kenneth
name: Noble, Mike
name: Guyer, Mark S.
name: Seidman, Jonathan
name: Sherman, Mark
name: Stuart, Joshua
name: Chen, Qing Rong
name: DiCara, Daniel
name: Boulos, Paul T.
name: Hoadley, Katherine A.
name: Brat, Daniel
name: Eoli, Marica
name: Eakin, Andrea
name: Hayes, D. Neil
name: Raghunathan, Aditya
name: Kalkanis, Steven
name: Otey, Ilana P.
name: Fulton, Robert S.
name: Kitko, Teresa
name: Poisson, Laila M.
name: Eckman, John
name: Zhang, Wei
name: Wilson, Richard K.
name: Czerinski, Christine
name: Ferguson, Martin L.
name: Thorsson, Vesteinn
name: Van Den Berg, David J.
name: Tarnuzzer, Roy
name: Cho, Juok
name: Spellman, Paul
name: Zhang, Hailei
name: Berger, Mitchel S.
name: Mikkelsen, Tom
name: Wan, Yunhu
name: Harr, Jodi
name: Lash, Alex
name: Weinstein, John N.
name: Yung, W. K.Alfred
name: Frentzen, Barbara
name: Mastrogianakis, Gena M.
name: Cuppini, Lucia
name: Fuller, Gregory N.
name: Swatloski, Teresa
name: Maderna, Emanuela
name: Carter, Scott L.
name: Liu, Wenbin
name: Gehlenborg, Nils
name: Ng, Sam
name: Sougnez, Carrie
name: McTiernan, Raquel
name: Zou, Lihua
name: Van Meir, Erwin G.
name: Heiman, David
name: Triche, Timothy J.
name: Balu, Saianand
name: Frazer, Scott
name: Lehman, Norman L.
name: Hansen, Nathan
name: Baylin, Stephen B.
name: Shelton, Troy
name: Ostrom, Quinn
name: Zheng, Siyuan
name: Annala, Matti J.
name: Yang, Liming
name: Yena, Peggy
name: Stojanov, Petar
name: Iype, Lisa
name: Sofia, Heidi J.
name: Dees, Nathan N.
name: Yang, Lixing
name: Yoon, Jae Geun
name: Mao, Yong
name: Bernard, Brady
name: Eppley, Matthew
name: Andrews, David W.
name: Getz, Gad
name: Morris, Scott
name: Foss, Robin
name: Eley, Greg
name: Lin, Pei
name: Socci, Nicholas D.
name: Vegesna, Rahulsimham
name: Sugarman, Michael
name: Laird, Peter W.
name: Gibbs, Richard
name: Auman, J. Todd
name: Ozenberger, Bradley A.
name: Kempista, Thelma
name: Wolinsky, Yingli
name: Voet, Doug
name: Cibulskis, Kristian
name: Paulauskis, Joseph
name: Sloan, Andrew E.
name: Lu, Yiling
name: Kucherlapati, Raju
name: Lee, Eunjung
name: Brown, Jenn
name: McKenna, Aaron
name: Friedman, William
name: Grifford, Mia
name: Ladanyi, Marc
name: Marra, Marco
name: Shmulevich, Ilya
name: Liu, Yingchun Spring
name: Harshyne, Larry
name: Hothi, Parvi
name: Wu, Chang Jiun
name: Zach, Leigh Anne
name: Mardis, Elaine R.
name: Jensen, Mark A.
name: Perou, Charles M.
name: Lawrence, Michael
name: Verhaak, Roel G.W.
name: Sheth, Margi
name: Sun, Youting
name: Ding, Li
name: Shi, Yan
name: Noushmehr, Houtan
name: Reva, Boris
name: Prados, Michael
name: Kreisberg, Richard B.
name: Rovira, Hector
name: Hatfield, Martha
name: Haussler, David
name: Dunn, Gavin
name: Lipp, Eric
name: Gabriel, Stacey B.
name: Koyfman, Yakov
name: Meyerson, Matthew
name: Kanchi, Krishna Latha
name: Liang, Yupu
name: Rabeno, Brenda
name: Ren, Xiaojia
name: Bergsten, Julie
name: Miller, C. Ryan
name: Mills, Gordon B.
name: Gross, Benjamin
name: Gutmann, David H.
name: Akbani, Rehan
name: Shelton, Candace
name: Giannini, Caterina
name: Gentry, Jeff
name: Reynolds, Sheila
name: Hadjipanayis, Angela
name: Demchok, John A.
name: DiMeco, Francesco
name: Winemiller, Cindy
name: Foltz, Greg
name: Smith, Christine
name: Wang, Zhining
name: Barrett, Wendi
name: Bogler, Oliver
name: Sloan, Andrew
name: McLendon, Roger
name: Onofrio, Robert C.
name: Weinstein, John
name: Finocchiaro, Gaetano
name: Shah, Nameeta
name: Viale, Agnes
name: Tabak, Barbara
name: Borsu, Laetitia
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: We describe the landscape of somatic genomic alterations based on multi-dimensional and comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify several novel mutated genes as well as complex rearrangements of signature receptors including EGFR and PDGFRA. TERT promoter mutations are shown to correlate with elevated mRNA expression, supporting a role in telomerase reactivation. Correlative analyses confirm that the survival advantage of the proneural subtype is conferred by the G-CIMP phenotype, and MGMT DNA methylation may be a predictive biomarker for treatment response only in classical subtype GBM. Integrative analysis of genomic and proteomic profiles challenges the notion of therapeutic inhibition of a pathway as an alternative to inhibition of the target itself. These data will facilitate the discovery of therapeutic and diagnostic target candidates, the validation of research and clinical observations and the generation of unanticipated hypotheses that can advance our molecular understanding of this lethal cancer.