cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
(:unas) unassigned
Creators: name: (:Unkn) Unknown
Publisher: name: Universita' degli Studi di Salerno
Year: 2024

description: Se nel finale della Vita Nuova Dante predisponeva il lettore all’evoluzione stilistica e semantica della Commedia, nel finale del poema lo pone faccia a faccia con il limite del suo disegno poetico: l’impossibilità di plasmare una lode del femminile che sia più solenne di quella stilnovistica e al contempo meno elevata di quella religiosa. Ciò determina una problematica di natura argomentativa – che Perelman riconduce al concetto di incompatibilità retorica – identificabile anche alla base della scelta dantesca di inserire san Berardo al termine del suo percorso ultramondano. Dante risolverebbe così che l’unico modo per non rischiare di ripetersi in un’identica lode sia quello di sostituire l’oratore al momento dell’incontro con la Vergine, salvaguardando l’originalità della sua ispirazione con cui ha portato a termine l’impegno explicitario della Vita Nuova.
description: If in the finale of the Vita Nuova Dante predisposed the reader to the stylistic and semantic evolution of the Comedy, the poem's ending puts him face to face with the limitations of his poetic design: the impossibility of molding a praise of the feminine that is more solemn than the stylnovistic one and at the same time less elevated than the religious one. This determines a problematic of an argumentative nature – which Perelman leads back to the concept of rhetorical incompatibility – also identifiable at the basis of Dante's choice to insert saint Berard at the end of his ultra worldly journey. Dante would thus resolve that the only way not to risk repeating himself in an identical praise is to replace the speaker at the time of the meeting with the Virgin, safeguarding the originality of his inspiration with which he completed the final commitment of the Vita Nuova.
Mechanistic considerations for human relevance of cancer hazard of di(2-ethylhexyl) phthalate
Creators: name: Corton, J. Christopher
name: Rusyn, Ivan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Di(2-ethylhexyl) phthalate (DEHP) is a peroxisome proliferator agent that is widely used as a plasticizer to soften polyvinylchloride plastics and non-polymers. Both occupational (e.g., by inhalation during its manufacture and use as a plasticizer of polyvinylchloride) and environmental (medical devices, contamination of food, or intake from air, water and soil) routes of exposure to DEHP are of concern for human health. There is sufficient evidence for carcinogenicity of DEHP in the liver in both rats and mice; however, there is little epidemiological evidence on possible associations between exposure to DEHP and liver cancer in humans. Data are available to suggest that liver is not the only target tissue for DEHP-associated toxicity and carcinogenicity in both humans and rodents. The debate regarding human relevance of the findings in rats or mice has been informed by studies on the mechanisms of carcinogenesis of the peroxisome proliferator class of chemicals, including DEHP. Important additional mechanistic information became available in the past decade, including, but not limited to, sub-acute, sub-chronic and chronic studies with DEHP in peroxisome proliferator-activated receptor (PPAR) α-null mice, as well as experiments utilizing several transgenic mouse lines. Activation of PPARα and the subsequent downstream events mediated by this transcription factor represent an important mechanism of action for DEHP in rats and mice. However, additional data from animal models and studies in humans exposed to DEHP from the environment suggest that multiple molecular signals and pathways in several cell types in the liver, rather than a single molecular event, contribute to the cancer in rats and mice. In addition, the toxic and carcinogenic effects of DEHP are not limited to liver. The International Agency for Research on Cancer working group concluded that the human relevance of the molecular events leading to cancer elicited by DEHP in several target tissues (e.g., liver and testis) in rats and mice can not be ruled out and DEHP was classified as possibly carcinogenic to humans (Group 2B).
Wealth of children from single-parent families: Low levels and high inequality in Germany
Creators: name: Lersch, Philipp M.
name: Grabka, Markus M.
name: Rüß, Kilian
name: Schröder, Carsten
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: wealth
subject: family
subject: children
subject: inequality
subject: separation
subject: 300 Sozialwissenschaften::330 Wirtschaft::330 Wirtschaft

description: Families’ economic wealth is a resource that can provide children with crucial advantages early in their lives. Prior research identified substantial variation of wealth levels between different family types with children from single-parent families being most disadvantaged. The causes of this disadvantage, how much the disadvantage varies between children and how the non-resident parents’ wealth may potentially reduce the disadvantage remain unclear. To address these research gaps, we use data from the German Socio-Economic Panel (2002–17) to examine the level of and inequality in wealth for children from single-parent families using recentred influence function regression and decomposition analysis. We replicate earlier findings of a large wealth disadvantage for children in single-parent families. We find that the wealth disadvantage can be mainly explained with compositional differences in household income and employment characteristics. Beyond level differences, inequality between children from single-parent families is higher than for other family types and this inequality can only partly be explained by observed demographic and socio-economic characteristics. When considering the wealth of non-resident parents, the wealth disadvantage of children in single-parent families is reduced but remains substantial.
Single Fixing Barrier Fade Option Valuation
Creators: name: Lee, David
Publisher: name: Zenodo
Year: 2022
Subjects: Single Fixing Barrier Fade Option Valuation

description: A Single Fixing Single Barrier Fade In Option gives a European payoff at expiry if a contractually fixed single barrier has been knocked on a specified single fixing (observation) date and gives nothing if otherwise. The “Out” version gives nothing if the barrier is knocked and a European payoff otherwise.
description: https://finpricing.com/lib/EqBarrier.html
Hydrogen Balmer Continuum in Solar Flares Detected by the Interface Region Imaging Spectrograph (IRIS)
Creators: name: Heinzel, Petr
name: Kleint, Lucia
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present a novel observation of the white-light flare (WLF) continuum, which was significantly enhanced during the X1 flare on March 29, 2014 (SOL2014-03-29T17:48). Data from the Interface Region Imaging Spectrograph (IRIS) in its NUV channel show that at the peak of the continuum enhancement, the contrast at the quasi-continuum window above 2813 Å reached 100 - 200 % and can be even larger closer to the Mg II lines. This is fully consistent with the hydrogen recombination Balmer continuum emission, which follows an impulsive thermal and non-thermal ionization caused by the precipitation of electron beams through the chromosphere. However, a less probable photospheric continuum enhancement cannot be excluded. The light curves of the Balmer continuum have an impulsive character with a gradual fading, similar to those detected recently in the optical region on Hinode/SOT. This observation represents a first Balmer-continuum detection from space far beyond the Balmer limit (3646 Å), eliminating seeing effects known to complicate the WLF detection. Moreover, we use a spectral window so far unexplored for flare studies, which provides the potential to study the Balmer continuum, as well as many metallic lines appearing in emission during flares. Combined with future ground-based observations of the continuum near the Balmer limit, we will be able to disentangle between various scenarios of the WLF origin. IRIS observations also provide a critical quantitative measure of the energy radiated in the Balmer continuum, which constrains various models of the energy transport and deposition during flares.
description: accepted by ApJL
The Role of ABCC6 Transporter in the Purinergic System: from Oncology to Regenerative Medicine
Creators: name: Abruzzese, Vittorio
Publisher: name: Universita degli studi di Salerno
Year: 2022
Subjects: subject: BIO/10 BIOCHIMICA

description: 2020 - 2021
description: ABCC6 is a member of ATP-binding cassette family of transporters, a class of membrane transporters sharing a common structural organization. Mutations in ABCC6 are associated with Pseudoxantoma elasticum (PXE) and with a minority of cases of Generalized Arterial Calcification of Infancy (GACI), two metabolic diseases characterized by an abnormal ectopic calcification of soft tissues. It is now recognized that ABCC6-mediated efflux of ATP from the liver is the main source of inorganic pyrophosphate, which is a strong anti- mineralization factor and is lacking in serum of patients with PXE or GACI. Extracellular ATP is not only important in controlling mineralization processes, as it is also a signaling molecule and is the main source of extracellular adenosine. Both ATP and adenosine can act as autocrine/paracrine signals, participating to the regulation of a variety of pathophysiological processes, through specific receptors. Purinergic signaling has a profound impact on tumor progression, affecting cancer cells proliferation, apoptosis, invasiveness and interaction with host immune response. Most of studies on ABCC6 focused on the identification of substrates in relation to its role in mineralization processes, but little information is available in regard of the consequences of transport activity in cells expressing ABCC6 protein. In this thesis we studied the effects of ABCC6 gene silencing and pharmacological inhibition on migration and cytoskeleton rearrangement of cancer cells, focusing at first on liver cancer cell line HepG2. Encouraged by results obtained in these cells, we tried to extend the relevance of our findings to extra hepatic tumors as well. We investigated the effects of pharmacological inhibition on two colorectal cancer cell lines, Caco2 and HT29, which significantly differ in the levels of expression of ABCC6. Finally, we evaluated the feasibility of using hepatocytes- like cells (HLCs) derived from amniotic epithelial stem cells as a substitute of primary hepatocytes to assess the potential toxic effects arising from ABCC6 inhibition in normal cells. Results reported here clearly show that in tumors where ABCC6 is highly expressed, it could have an important role in controlling cancer cells migration, through the modulation of extracellular purinergic signaling, thus representing a potential target for anti-cancer treatments aimed to reduce tumor invasiveness. HLCs derived from pluripotent stem cells represent a promising tool not only for regenerative medicine but also for disease modeling and toxicological studies. However, improvements in current protocols of in vitro differentiation are required to broaden the scope of this technology to routine toxicological studies. [edited by Author]
Trichloroethylene biotransformation and its role in mutagenicity, carcinogenicity and target organ toxicity
Creators: name: Rusyn, Ivan
name: Lash, Lawrence H.
name: Chiu, Weihsueh A.
name: Guyton, Kathryn Z.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Metabolism is critical for the mutagenicity, carcinogenicity, and other adverse health effects of trichloroethylene (TCE). Despite the relatively small size and simple chemical structure of TCE, its metabolism is quite complex, yielding multiple intermediates and end-products. Experimental animal and human data indicate that TCE metabolism occurs through two major pathways: cytochrome P450 (CYP)-dependent oxidation and glutathione (GSH) conjugation catalyzed by GSH S-transferases (GSTs). Herein we review recent data characterizing TCE processing and flux through these pathways. We describe the catalytic enzymes, their regulation and tissue localization, as well as the evidence for transport and inter-organ processing of metabolites. We address the chemical reactivity of TCE metabolites, highlighting data on mutagenicity of these end-products. Identification in urine of key metabolites, particularly trichloroacetate (TCA), dichloroacetate (DCA), trichloroethanol and its glucuronide (TCOH and TCOG), and N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine (NAcDCVC), in exposed humans and other species (mostly rats and mice) demonstrates function of the two metabolic pathways in vivo. The CYP pathway primarily yields chemically stable end-products. However, the GST pathway conjugate S-(1,2-dichlorovinyl)glutathione (DCVG) is further processed to multiple highly reactive species that are known to be mutagenic, especially in kidney where in situ metabolism occurs. TCE metabolism is highly variable across sexes, species, tissues and individuals. Genetic polymorphisms in several of the key enzymes metabolizing TCE and its intermediates contribute to variability in metabolic profiles and rates. In all, the evidence characterizing the complex metabolism of TCE can inform predictions of adverse responses including mutagenesis, carcinogenesis, and acute and chronic organ-specific toxicity.
Firm foundations: The statistical footprint of multinational corporations as a problem for political economy
Creators: name: Ergen, Timur
name: Kohl, Sebastian
name: Braun, Benjamin
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: growth models
subject: financialization
subject: multinational corporations
subject: economic indicators
subject: comparative methods
subject: globalization
subject: 300 Sozialwissenschaften::330 Wirtschaft::330 Wirtschaft

description: The discipline of comparative political economy (CPE) relies heavily on aggregate, country-level economic indicators. However, the practices of multinational corporations have increasingly undermined this approach to measurement. The problem of indicator drift is well documented by a growing critical literature and calls for systematic methodological attention in CPE. We present the case for a rocky but ultimately rewarding middle road between indicator fatalism and indicator faith. We illustrate our argument by examining two important cases—Sweden’s recent export success and the financialization of non-financial corporations in France. A careful parsing of the data suggests corrections to common characterizations of the two cases. Swedish exports have been reshaped by intragroup trade among foreign subsidiaries of domestic corporations. The growth of financial assets held by French firms is attributable to the growth of foreign direct investment and to cumulative revaluation effects, while what remains of financialization is concentrated among the very largest firms. Based on these findings, we propose a methodological routine that parses data by zooming in on the qualitative specifics of countries, sectors, and firms, while using all available options for disaggregation.
Religiöse Identitäten als Problem wechselseitiger Identifizierungen und Kategorisierungen: Aktuelle theoretische Konzepte und Fragen ihrer Operationalisierung in der empirischen Religionsforschung
Creators: name: Liedhegener, Antonius (Author)
Publisher: name: Zenodo
Year: 2016

description: Keine Beschreibung
description: + ID der Publikation: unilu_7837 + Reihe: Politik und Religion + Sprache: Deutsch + Letzte Aktualisierung: 2018-06-27 17:46:14
A VLA monitoring study of JVAS B1422+231: investigation of time delays and detection of extrinsic variability
Creators: name: Biggs, A. D.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present an analysis of two seasons of archival, multi-frequency VLA monitoring of the quad lens system JVAS B1422+231, the 15-GHz data of which have previously been published. The 8.4- and 15-GHz variability curves show significant variability, especially in polarization, but lack features on short time-scales that would be necessary for an accurate measurement of the very short predicted time delays ($\le$1 d) between the three bright images. Time delays can only realistically be measured to the very faint image D and for the first time we detect its long-term variability and determine its polarization properties. However, image-dependent (extrinsic) variability (including variations on time-scales of hours) is present in multiple images and the magnitude of this is largest in image D at 15 GHz ($\pm$10 per cent). As the variations appear to increase in amplitude with frequency, we suggest that the most likely cause is microlensing by compact objects in the lensing galaxy. Combining the monitoring data allows us to detect a faint arc of emission lying between images B and C and the jets responsible for this are imaged using archival VLBA data. Finally, we have also measured the rotation measure of the three bright images and detected the polarization properties of image D.
description: 12 pages, 9 figures, accepted for publication in MNRAS
Functional Characterization and Atomic Force Microscopy of a DNA Repair Protein Conjugated to a Quantum Dot
Creators: name: Croteau, Deborah L.
name: Erie, Dorothy A.
name: Tessmer, Ingrid
name: Wang, Hong
name: Van Houten, Bennett
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Quantum dots (QDs) possess highly desirable optical properties that make them ideal fluorescent labels for studying the dynamic behavior of proteins. However, a lack of characterization methods for reliably determining protein–quantum dot conjugate stoichiometry and functionality has impeded their widespread use in single-molecule studies. We used atomic force microscopic (AFM) imaging to demonstrate the 1:1 formation of UvrB–QD conjugates based on an antibody-sandwich method. We show that an agarose gel-based electrophoresis mobility shift assay and AFM can be used to evaluate the DNA binding function of UvrB–QD conjugates. Importantly, we demonstrate that quantum dots can serve as a molecular marker to unambiguously identify the presence of a labeled protein in AFM images.
Fabrication of Sub-5 nm Nanochannels in Insulating Substrates Using Focused Ion Beam Milling
Creators: name: Menard, Laurent D.
name: Ramsey, J. Michael
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The use of focused ion beam (FIB) milling to fabricate nanochannels with critical dimensions extending below 5 nm is described. FIB milled lines have narrowing widths as they are milled deeper into a substrate. This focusing characteristic is coupled with a two-layered architecture consisting of a relatively thick (>100 nm) metal film deposited onto a substrate. A channel is milled through the metal layer until it penetrates a prescribed depth into the substrate material. The metal is then removed, leaving a nanochannel with smooth surfaces and lateral dimensions as small as sub-5 nm. These open nanochannels can be sealed with a cover plate and the resulting devices are well-suited for single-molecule DNA transport studies. This methodology is used with quartz, single-crystal silicon, and polydimethylsiloxane substrates to demonstrate its general utility.
On the Application of Generic Summarization Algorithms to Music
Creators: name: Raposo, Francisco
name: Ribeiro, Ricardo
name: de Matos, David Martins
Publisher: name: arXiv
Year: 2014
Subjects: subject: Information Retrieval (cs.IR)
subject: Machine Learning (cs.LG)
subject: Sound (cs.SD)
subject: FOS: Computer and information sciences
subject: H.5.5

description: Several generic summarization algorithms were developed in the past and successfully applied in fields such as text and speech summarization. In this paper, we review and apply these algorithms to music. To evaluate this summarization's performance, we adopt an extrinsic approach: we compare a Fado Genre Classifier's performance using truncated contiguous clips against the summaries extracted with those algorithms on 2 different datasets. We show that Maximal Marginal Relevance (MMR), LexRank and Latent Semantic Analysis (LSA) all improve classification performance in both datasets used for testing.
description: 12 pages, 1 table; Submitted to IEEE Signal Processing Letters
Is it still disintermediated? The role of the influencer news-maker in the social platform era
Creators: name: Acampa, Suana
name: Crescentini, Noemi
name: Giuseppe Michele, Padricelli
Publisher: name: Universita' degli Studi di Salerno
Year: 2022
Subjects: Journalism studies
Social media analysis
Content analysis

description: n the last 20 years, the Internet revolution has driven the traditional news-models featured by the journals' gatekeeping towards a brand-new disintermediated logic made by prosumers. This phenomenon has drastically reshaped the logics of the news dissemination, forcing a rethink of journalists’ role. Through a research design based on a content analysis conducted on Facebook, the aim of this paper is to identify the features of the journalists’ reinvention today we can define as influencer news-makers. To achieve our research goal, we identified five of the most influential Italian journalists on social media, and the respective publishers they work with. Analyzing about 20,000 social media posts, the main results from this study concern the emergence of two different profiles: the journalist who reinvents traditional news making practices by exploiting the logics of social media and the journalist who integrates the promotion practices of his own content in the gatekeeping process
Transparency and Openness in Peer Review - Examples from a Student Journal
Creators: name: Keles, Amelya
name: Speh, Jonathan
name: Leuner, Raphael
Publisher: name: Zenodo
Year: 2022
Subjects: peer review
student research
preprint
public review
scientific publishing

description: This presentation was held at the german Open Science Festival 2022 in Hanover as a part of the Workshop "Transparency and Openness in Peer Review: Towards a new publication and evaluation culture." The Workshop was co-organised by members of Berlin Exchange Medicine and Ludo Waltman from the Centre for Science and Technology Studies at Leiden University, whose presentation can be found here.
Relationships between riverine fish and woody debris: implications for lowland rivers
Creators: name: Crook, D. A
name: Robertson, A. I
Publisher: name: La Trobe
Year: 2023

description: La Trobe University Faculty of Science, Technology and Engineering Murray Darling Freshwater Research Centre

MDFRC item.

This paper reviews studies of relationships between riverine fish and woody debris at micro- and meso-habitat scales, and discusses the potential functions of instream structure for lowland river fish. Experimental research, mainly in North America, has identified three main functions of woody debris as microhabitat for fish in upland streams: overhead cover that decreases predation risk both vertically and horizontally; horizontal visual isolation that reduces contact between fish; and velocity refuge which minimizes energetic costs. As with habitat features in other aquatic environments, increasing spatial complexity of woody debris may modify predator–prey interactions and provide greater surface areas for the growth of prey items. Woody debris may also provide spatial reference points for riverine fish to assist them in orienting within their surroundings. Lowland rivers differ from upland streams in terms of a number of physical variables, including turbidity, depth and water turbulence. Relationships between fish and woody debris in lowland rivers are likely to rely on mechanisms different to those in upland streams. Recent initiatives involving the reintroduction of woody debris into previously cleared lowland rivers to replace lost fish habitat are a positive development for lowland river restoration. However, if woody debris reintroduction is to maximally benefit lowland river fisheries, there is a requirement for better understanding of the ecological functions of woody debris in lowland rivers.
Potent Engineered PLGA Nanoparticles by Virtue of Exceptionally High Chemotherapeutic Loadings
Creators: name: Napier, Mary E.
name: Luft, J. Christopher
name: DeSimone, Joseph M.
name: Enlow, Elizabeth M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Herein we report the fabrication of engineered poly(lactic acid-co-glycolic acid) nanoparticles via the PRINT® (Particle Replication In Non-wetting Templates) process with high and efficient loadings of docetaxel, up to 40% (w/w) with encapsulation efficiencies >90%. The PRINT process enables independent control of particle properties leading to a higher degree of tailorability than traditional methods. Particles with 40% loading display better in vitro efficacy than particles with lower loadings and the clinical formulation of docetaxel, Taxotere®.
Data Stewards of the Data Science Center at the University of Bremen | Roles and perspectives
Creators: name: Lilkendey, Julian
name: Thöricht, Heike
name: Zänkert, Sandra
Publisher: name: Zenodo
Year: 2022
Subjects: Data Steward
Data Stewardship
Research Data Management

description: We presented the work of the data stewards at the University of Bremen and how they help to establish an open research culture in the multi-disciplinary U Bremen Research Alliance. Sustainable research data management (RDM) is an integral part of an open research agenda. However, modern RDM goes beyond the concept of open data. It aims at optimising the reuse of data by adhering to the FAIR principles - making data Findable, Accessible, Interoperable and Reusable. These principles affect all levels of the research data life cycle. But implementation of new tools and technologies or even a complete redesign of existing workflows can feel like an overwhelming task for researchers. At the University of Bremen, data stewards will complement the existing RDM support infrastructures and facilitate this change process. They provide practical and discipline-specific support, including data literacy trainings for scientists, help with proposal writing and putting data management plans into action. Networking and the exchange with colleagues, experts and researchers interested in RDM related topics also play an important role in our work. Therefore, we engaged in conversation with you at the Open Science Festival and shared experiences and perspectives on FAIR data and data stewardship.
Multiparametric ultrasound findings in acute kidney failure due to rare renal cortical necrosis
Creators: name: Spiesecke, Paul
name: Münch, Frédéric
name: Fischer, Thomas
name: Hamm, Bernd
name: Lerchbaumer, Markus H.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Renal cortical necrosis
subject: acute kidney failure
subject: Contrast-enhanced ultrasound
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Renal cortical necrosis (RCN) is a rare cause of acute kidney failure and is usually diagnosed on the basis of characteristic enhancement patterns on cross-sectional imaging. Contrast-enhanced ultrasound (CEUS) offers benefits in patients with kidney failure in the clinical setting including the use of a nonnephrotoxic intravascular contrast agent and the fact that it can be performed at the bedside in critical cases. Therefore, the aim of this study is to investigate whether CEUS can reliably identify typical imaging features of RCN. We retrospectively analyzed 12 patients with RCN examined in our department and confirmation of the diagnosis by either histopathology, other contrast-enhanced cross-sectional imaging tests, and/or CEUS follow-up. Assessed parameters in conventional US were reduced echogenicity, loss of corticomedullary differentiation, length and width of kidney, hypoechoic rim, resistance index and in CEUS delayed wash-in of contrast agent (>20 s), reverse rim sign, maximum nonenhancing rim and additional renal infarction. Furthermore, imaging features in RCN were compared with the findings in renal vein thrombosis (RVT), among them echogenicity, corticomedullar differentiation, hypoechoic rim, RI value, delayed cortical enhancement, total loss of cortical perfusion and enhancement of renal medulla. All 12 patients showed the reverse rim sign, while a hypoechogenic subcapsular rim was only visible in four patients on B-mode ultrasound. A resistance index (RI) was available in 10 cases and was always less than 1. RI was a strong differentiator in separating RVT from RCN (RI>1 or not measurable due to hypoperfusion as differentiator, p=0.001). CEUS showed total loss of medullary enhancement in all cases of RVT. With its higher temporal resolution, CEUS allows dynamic assessment of renal macro- and microcirculation and identification of the typical imaging findings of RCN with use of a nonnephrotoxic contrast agent.
Relativistic Polytropic Models of Charged Anisotropic Compact Object
Creators: name: Nazar, H.
name: Azam, M.
name: Abbas, G.
name: Ahmed, R.
name: Naeem, R.
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this paper, we have introduced new viable solutions of Einstein-Maxwell field equations by incorporating the features of anisotropic matter distribution in the realm of General theory of Relativity ($GR$). For this procurement, we have employed a Finch-Skea spacetime along with a generalized polytropic equation of state ($EoS$). We have constructed various models of generalized polytropes by assuming the different choices of the polytropic index i.e.,$η=\frac{1}{2}, \frac{2}{3}, 1$ and $2$. The numerous physical characteristics of these considered models have been studied via graphical analysis, which obey all the essential conditions of the astrophysical compact objects. Furthermore, such outcomes of charged anisotropic compact star models can be regained to the various cases such as linear, quadratic and polytropic $EoS$.
description: 31 Pages, 11 Figures, 1 Table. Published in Chinese Phys. C
Rural Conditions and Trends
Creators: name: USDA ERS
name: USDA ERS
Publisher: name: Unknown
Year: 1993
Subjects: Community/Rural/Urban Development

description: Overview: Rural Conditions Stable While Urban Conditions Slip; National Economic Conditions: Economy on the Mend; Employment: Rural Employment Picks Up in 1992; Unemployment: Rural Unemployment Finally Eases; Industry: Manufacturing Job Losses Concentrated in Urban Areas in 1990; Earnings: Earnings per Job Declined in 1990; Income: Rural Household Income Stagnates; Poverty: Rural Poverty Stable, But Still Higher Than Urban; Population: Rural Health Insurance Coverage Differs From Urban; Appendix: Data Sources and Definitions; Appendix Tables
title: Οι επιπτώσεις της πανδημίας στις ελληνικές επιχειρήσεις
title: The impact of the pandemic on Greek businesses
titleType: AlternativeTitle
Creators: name: Κότση, Σταυρούλα
Publisher: name: Πανεπιστήμιο Πελοποννήσου
Year: 2022
Subjects: subject: COVID 19- Πανδημία, 2020 -- Οικονομικές απόψεις
subject: Οικονομική κρίση
subject: Πανδημία Covid-19
subject: Ελληνικές επιχειρήσεις
subject: Κρατικές παρεμβάσεις
subject: Covid-19 pandemic
subject: Greek business
subject: State interventions

description: Μ.Δ.Ε. 13
description: Το πρώτο τρίμηνο του 2020 η παγκόσμια κοινότητα κλονίστηκε από ένα πρωτοφανές, για τουλάχιστον έναν αιώνα, γεγονός, δηλαδή, την εκδήλωση της πανδημίας του Covid-19 που ξεκίνησε από την Κίνα. Άμεσα, η πανδημία εξαπλώθηκε σε όλο τον κόσμο, προκαλώντας την νόσηση, αλλά και τον θάνατο εκατομμυρίων ανθρώπων. Μέχρι και σήμερα, σχεδόν τρία χρόνια μετά, η πανδημία εξακολουθεί να επηρεάζει την καθημερινότητα των ανθρώπων κι έχει αναμορφώσει τον τρόπο με τον οποίο λειτουργεί η οικονομία. Ως ξαφνικό και απρόσμενο γεγονός, η πανδημία ανατάραξε την διεθνή οικονομία και δημιούργησε συνθήκες ύφεσης με αβέβαιη διέξοδο. Η κοινωνική αποστασιοποίηση, η αναστολή της παραγωγικής διαδικασίας και η κάθετη μείωση των μετακινήσεων επέδρασαν αρνητικά στην πλειοψηφία των τομέων της ανθρώπινης δραστηριότητας. Αν και σαφώς ο βασικός αντίκτυπος ήταν η απειλή της ανθρώπινης ζωής, η πανδημία λειτούργησε κατασταλτικά και στην επιχειρηματική δραστηριότητα. Η παρούσα διπλωματική εργασία εστιάζει στην περίπτωση των επιπτώσεων της πανδημίας Covid-19 στις ελληνικές επιχειρήσεις. Μέσω της βιβλιογραφικής ανασκόπησης επιχειρήθηκε να αναδειχθούν τα σημαντικότερα προβλήματα που ανέκυψαν για τις ελληνικές επιχειρήσεις, εν μέσω της πανδημίας, καθώς και οι πρωτοβουλίες που αναλήφθηκαν από το κράτος ώστε να μετριαστεί η ύφεση. Η έλλειψη ρευστότητας και η απότομη μείωση στον κύκλο εργασιών, λόγω της μειωμένης ζήτησης στους περισσότερους τομείς της οικονομίας, η εκτεταμένη ζημιά στον τουρισμό και το πρόβλημα της διατήρησης της απασχόλησης φαίνεται ότι αποτέλεσαν τα βασικά προβλήματα για τους Έλληνες επιχειρηματίες. Στα πλαίσια αυτά, το κράτος προχώρησε σε έκτακτες ενισχύσεις ρευστότητας, φορολογικές ελαφρύνσεις και στήριξη της απασχόλησης.
title: Indirect impacts of a non-native ungulate browser on soil ecosystem function is variable across soil horizons in the boreal forests of Newfoundland, Canada
Creators: name: Swain, Makayla
Publisher: name: Memorial University of Newfoundland
Year: 2021

description: Herbivores are key players in ecosystem function and connect nutrient cycling across animal and plant trophic levels. Herbivore impacts on ecosystems can be direct or indirect and it is necessary to study both paths to understand herbivore impacts on above-ground and below-ground ecosystem functioning. We conducted an experiment to test the hypothesis that non-native moose on the island of Newfoundland have negative impacts on plant communities, nutrient cycling, soil composition, and soil organism communities. We collected data on plant and invertebrate communities, climate, and soils in 11 paired exclosure-control plots in eastern and central Newfoundland that provide insight into 22-25 years of moose herbivory. Structural equations models revealed that moose had direct negative impacts on palatable tree height and abundance and an indirect negative impact on soil microbial C:N ratios. We found that moose had a direct negative impact on soil horizon depth and plant material and a positive impact on soil temperature and moisture, particularly in the first soil horizon. We detected no significant impact of moose on soil total C and N, net nitrogen mineralization, or macro-invertebrate communities. Overall, we unearthed evidence of indirect cascading impacts of moose on soil functions although these impacts are relatively weak.
Delivery of Multiple siRNAs Using Lipid-Coated PLGA Nanoparticles for Treatment of Prostate Cancer
Creators: name: DeSimone, Joseph M.
name: Rolland, Jason P.
name: Hasan, Warefta
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Nanotechnology can provide a critical advantage in developing strategies for cancer management and treatment by helping to improve the safety and efficacy of novel therapeutic delivery vehicles. This paper reports the fabrication of poly(lactic acid-co-glycolic acid)/siRNA nanoparticles coated with lipids for use as prostate cancer therapeutics made via a unique soft lithography particle molding process called PRINT (Particle Replication In Nonwetting Templates). The PRINT process enables high encapsulation efficiency of siRNA into neutral and monodisperse PLGA particles (32–46% encapsulation efficiency). Lipid-coated PLGA/siRNA PRINT particles were used to deliver therapeutic siRNA in vitro to knockdown genes relevant to prostate cancer.
Multiphysics simulations of fire inside the cavity of a facade
Creators: name: Khoo Sheng Yeong, Benjamin
Publisher: name: Imperial College London
Year: 2022

description: The facade system is highly complex and requires achieving multiple objectives to provide occupants with a safe and comfortable environment. Any attempt to improve these objectives, such as aesthetic, thermal or acoustic insulation, could potentially affect the fire safety of the facade system. This is especially true as novel materials were introduced over the last decades, resulting in an ongoing rise in facade fires. Researchers have observed that a narrow cavity in a facade system encourages rapid facade fire spread. Unfortunately, there is little knowledge of quantifying the impact of cavities on a facade fire. Computational Fluid Dynamics (CFD) fire simulation represents an excellent tool to complement experimental studies on fire inside a narrow cavity of a flammable facade. Cavity fire is a multiphysics phenomenon, and all physics, i.e. fluid flow, heat transfer, buoyancy, combustion and pyrolysis involved in the model must be coupled step-by-step for a narrow cavity fire scenario to ensure model reliability. This thesis provides a step-by-step development of a CFD simulation for a narrow cavity fire. We split the facade cavity fire into six different scenarios with increasing complexity and validated the model against experimental data in the literature to limit the compensation effect. The compensation effect is the concept where similar results could be obtained by varying two or more parameters. We studied how cavity barriers affect fire dynamics and performed parametric studies to quantify the impact of both material properties and cavity width on fire dynamics inside a cavity of a flammable facade. This work demonstrates that modelling represents a powerful tool to aid in understanding facade cavity fire to improve building fire safety.
On the central symmetry of the circumstellar envelope of RS Cnc
Creators: name: Nhung, Pham Tuyet
name: Hoai, Do Thi
name: Winters, Jan Martin
name: Darriulat, Pierre
name: Gérard, Eric
name: Bertre, Thibaut Le
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present a phenomenological study of CO(1-0) and CO(2-1) emission from the circumstellar envelope (CSE) of the Asymptotic Giant Branch (AGB) star RS\,Cnc. It reveals departures from central symmetry that turn out to be efficient tools for the exploration of some of the CSE properties. We use a wind model including a bipolar flow with a typical wind velocity of $\sim$8 km\,s$^{-1}$ decreasing to $\sim$2 km\,s$^{-1}$ near the equator to describe Doppler velocity spectral maps obtained by merging data collected at the IRAM Plateau de Bure Interferometer and Pico Veleta single dish radio telescope. Parameters describing the wind morphology and kinematics are obtained, together with the radial dependence of the gas temperature in the domain of the circumstellar envelope probed by the CO observations. Significant north-south central asymmetries are revealed by the analysis, which we quantify using a simple phenomenological description. The origin of such asymmetries is unclear.
description: accepted for publication in Research in Astronomy and Astrophysics (RAA)
Epidemiology and Outcomes in Paediatric Inflammatory Bowel Disease
Creators: name: Hussey, Seamus
Publisher: name: Royal College of Surgeons in Ireland
Year: 2025
Subjects: classificationCode: 3213
subject: Paediatrics
classificationCode: 320209
subject: Gastroenterology and hepatology

description: Background: Ireland has a single national centre for paediatric inflammatory bowel disease (IBD). Crohn’s disease (CD) and ulcerative colitis (UC) account for over 90% of subtypes. National incidence and outcomes data are limited, as are relapse predictors in CD. 
Aims: This thesis will detail the incidence and outcomes of early-inset IBD (EO-IBD), of acute severe UC (ASUC), and describe predictors of early relapse in paediatric CD. 
Methods: Retrospective and prospective data collection methods were used. Patients were phenotyped by Paris classification of IBD, and disease activity was measured by the respective paediatric indices for CD and UC. All Irish cases of EO-IBD between the years 2000 and 2014 were reviewed, and primary outcomes were remission by 1 year and surgical rates. The files of all patients with ASUC from 2009-2015 were reviewed and analysed for steroid responsiveness, colectomy rate and infliximab outcomes. Data were collected prospectively in the international GROWTH study, and predictors of relapse by 18 months were determined from data at baseline and follow-up, and a predictor tool was generated. 
Results: Between 2000 and 2014, 199 Irish children (50% males) were diagnosed with EOIBD. A significant increase in UC incidence, of 0.06/100,000 per year, was noted. Male patients with CD had more extensive distribution and severe disease activity at diagnosis than females. Isolated colonic disease and relapse rates were significantly higher in EO-IBD than in older-onset disease. There were 55 patients diagnosed with ASUC from 2009-2015. The colectomy rate fell from 88% pre-2011 to 36% afterwards, following infliximab introduction. Most (70%) required infliximab intensification but there were no clear predictors of outcomes. The GROWTH study followed 178 patients in week-12 remission. Multivariable analysis found that CRP >20mg/L, faecal calprotectin >400ug/g and PCDAI >5 were predictive of relapse in the predictor tool.
Conclusion: The incidence of EO-IBD is rising and males have worse outcomes. Infliximab has improved ASUC outcomes, including colectomy rates. Relapse risk is lower with combined clinical and inflammatory marker remission by week 12 in CD.
Measurement of the charge asymmetry in beauty-dijet production at the LHCb experiment
Creators: name: Bradley, Matt
Publisher: name: Imperial College London
Year: 2023

description: A measurement of the charge asymmetry in beauty-dijet production at LHCb is presented in this thesis. The measurement uses the 2016 dataset of proton-proton collisions gathered by the detector, corresponding to an integrated luminosity of 1.7 fb-1. The charge asymmetry is measured in three bins of the invariant dijet mass, with bin edges at: [50, 75, 105, 150] GeV. This represents the first measurement of the charge asymmetry in beauty-dijet production in proton-proton collisions at a centre-of-mass energy of 13 TeV. To make the measurement a charge tagging method is first developed and tested in order to distinguish between the presence of b- and anti-b-quarks in jets. The calibration of simulated events is then carried out to correct for mismodelling when compared to the data. Next, fits are performed to extract the yield of beauty-dijets in the data sample. These yields are then corrected for detector and mistagging effects. The values of the asymmetry are then calculated. Results are compared to Standard Model predictions and are found to agree to within one standard deviation in all three bins.
Stellar associations powering HII regions $\unicode{x2013}$ I. Defining an evolutionary sequence
Creators: name: Scheuermann, Fabian
name: Kreckel, Kathryn
name: Barnes, Ashley T.
name: Belfiore, Francesco
name: Groves, Brent
name: Hannon, Stephen
name: Lee, Janice C.
name: Minsley, Rebecca
name: Rosolowsky, Erik
name: Bigiel, Frank
name: Blanc, Guillermo A.
name: Boquien, Médéric
name: Dale, Daniel A.
name: Deger, Sinan
name: Egorov, Oleg V.
name: Emsellem, Eric
name: Glover, Simon C. O.
name: Grasha, Kathryn
name: Hassani, Hamid
name: Jeffreson, Sarah
name: Klessen, Ralf S.
name: Kruijssen, J. M. Diederik
name: Larson, Kirsten L.
name: Leroy, Adam K.
name: Lopez, Laura
name: Pan, Hsi-An
name: Sánchez-Blázquez, Patricia
name: Santoro, Francesco
name: Schinnerer, Eva
name: Thilker, David A.
name: Whitmore, Brad C.
name: Watkins, Elizabeth J.
name: Williams, Thomas G.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Connecting the gas in HII regions to the underlying source of the ionizing radiation can help us constrain the physical processes of stellar feedback and how HII regions evolve over time. With PHANGS$\unicode{x2013}$MUSE we detect nearly 24,000 HII regions across 19 galaxies and measure the physical properties of the ionized gas (e.g. metallicity, ionization parameter, density). We use catalogues of multi-scale stellar associations from PHANGS$\unicode{x2013}$HST to obtain constraints on the age of the ionizing sources. We construct a matched catalogue of 4,177 HII regions that are clearly linked to a single ionizing association. A weak anti-correlation is observed between the association ages and the H$α$ equivalent width EW(H$α$), the H$α$/FUV flux ratio and the ionization parameter, log q. As all three are expected to decrease as the stellar population ages, this could indicate that we observe an evolutionary sequence. This interpretation is further supported by correlations between all three properties. Interpreting these as evolutionary tracers, we find younger nebulae to be more attenuated by dust and closer to giant molecular clouds, in line with recent models of feedback-regulated star formation. We also observe strong correlations with the local metallicity variations and all three proposed age tracers, suggestive of star formation preferentially occurring in locations of locally enhanced metallicity. Overall, EW(H$α$) and log q show the most consistent trends and appear to be most reliable tracers for the age of an HII region.
description: 15 pages, 12 figures. Accepted for publication in MNRAS
PEGylated PRINT Nanoparticles: The Impact of PEG Density on Protein Binding, Macrophage Association, Biodistribution, and Pharmacokinetics
Creators: name: Herlihy, Kevin P.
name: Perry, Jillian L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: In this account, we varied PEGylation density on the surface of hydrogel PRINT nanoparticles and systematically observed the effects on protein adsorption, macrophage uptake, and circulation time. Interestingly, the density of PEGylation necessary to promote a long-circulating particle was dramatically less than what has been previously reported. Overall, our methodology provides a rapid screening technique to predict particle behavior in vivo and our results deliver further insight to what PEG density is necessary to facilitate long-circulation.