cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Guidance, navigation and control for autonomous spacecraft based on convex optimization techniques
Creators: name: Bernardini, Nicolò
Publisher: name: University of Surrey
Year: 2024
Subjects: GNC
Space Mission Design
Convex Optimization
Differential algebra
Astrodynamics
Autonomous Vehicles
Navigation and Guidance Systems

description: In the recent decade, we witnessed a remarkable proliferation of spacecraft orbiting around Earth and venturing farther into our Solar system. As the number of operated spacecraft increases, the complexity of managing multiple missions escalates, along with the associated costs. Deep space missions will require spacecraft to navigate through challenging trajectories with limited and delayed communications. This makes autonomy crucial for ensuring the success of these missions. Convex optimization has emerged as a promising technique for autonomous guidance and navigation algorithms thanks to its computational speed and convergence properties. Only recently convex optimization has been adopted to solve non-linear optimization problems thanks to the introduction of successive convex programming (SCVX) enabling its application to a wide range of astrodynamics problems. In this research, differential algebra techniques are applied to improve the performances of SCVX by introducing a novel state-dependent trust region that enhances the robustness and optimality of SCVX techniques. The application of SCVX is then successfully expanded to operations around small celestial bodies. Furthermore, to improve the targeting of periodic and quasi-periodic orbits a new methodology based on the representation of these trajectories with their Fourier series is introduced. As spacecraft trajectories are susceptible to various sources of errors, the covariance of the state is included in the optimal control problem to obtain covariance robust trajectories that enable the containing of the expansion of the uncertainties. At the same time, differential algebra is applied to include the effects of the measurements in the optimization process. Finally, a novel convex-based autonomous guidance and navigation algorithm based on high-order Taylor expansions is presented. The new guidance and navigation algorithm enables the exploration of different penalty functions for the estimation process. At the same time, using high-order polynomials allows for the improvement of the computational efficiency of the guidance and navigation algorithm.
title: Flanking sequences influence the activity of TET1 and TET2 methylcytosine dioxygenases and affect genomic 5hmC patterns
Creators: name: Adam, Sabrina
name: Bräcker, Julia
name: Klingel, Viviane
name: Osteresch, Bernd
name: Radde, Nicole E.
name: Brockmeyer, Jens
name: Bashtrykov, Pavel
name: Jeltsch, Albert
Publisher: name: Universität Stuttgart
Year: 2022
Subjects: subject: 540

description: TET dioxygenases convert 5-methylcytosine (5mC) preferentially in a CpG context into 5-hydroxymethylcytosine (5hmC) and higher oxidized forms, thereby initiating DNA demethylation, but details regarding the effects of the DNA sequences flanking the target 5mC site on TET activity are unknown. We investigated oxidation of libraries of DNA substrates containing one 5mC or 5hmC residue in randomized sequence context using single molecule readout of oxidation activity and sequence and show pronounced 20 and 70-fold flanking sequence effects on the catalytic activities of TET1 and TET2, respectively. Flanking sequence preferences were similar for TET1 and TET2 and also for 5mC and 5hmC substrates. Enhanced flanking sequence preferences were observed at non-CpG sites together with profound effects of flanking sequences on the specificity of TET2. TET flanking sequence preferences are reflected in genome-wide and local patterns of 5hmC and DNA demethylation in human and mouse cells indicating that they influence genomic DNA modification patterns in combination with locus specific targeting of TET enzymes.
Bürden des Krieges
Creators: name: Theissen, Christopher
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Kinder sind Vietnams Zukunft. Dort möchte die Führung in Hanoi hin. Doch noch nicht gelöste Probleme erlauben keinen zweiten Schritt vor dem ersten. Ein großes Problem stellt dabei die mangelnde Versorgung behinderter Kinder dar.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 18 Nr. 3 (2002): Kindsköpfe: Kinder in Südostasien
Exploring the Role of Self-Compassion and Self-Criticism on Maternal-Infant Attachment and Infant Feeding
Creators: name: NEWMAN, REBECCA
Publisher: name: University of Surrey
Year: 2022

description: Self-compassion is currently a rapidly expanding area of research. One area in which self-compassion is being applied is during pregnancy and in the first year postnatal. This time is known to be a point where women experience increased vulnerability to mental health difficulties and a drop in their overall wellbeing. Maternal psychological distress has been linked to poorer maternal-infant attachment and poor mother and infant outcomes. One area which women report as an area of difficulty is infant feeding, the challenges and method in which women feed their children has been associated with feelings of shame and guilt. I have been struck while talking to people about this just how intense and long lasting these feelings can be. Self-compassion has been reported to protect against feelings of shame in a range of contexts. Part one of this portfolio presents empirical research into a self-compassion intervention and the relationships between self-compassion, shame and guilt associated with infant feeding, maternal infant attachment and breastfeeding outcomes. While the intervention was not found to significantly impact levels of self-compassion, the study found significant evidence for self-compassion’s relationship with shame, guilt, maternal-infant attachment and breastfeeding outcomes, highlighting the role of self-compassion in maternal wellbeing in the perinatal period. Part two of this portfolio presents a systematic review of the relationship between self-compassion and wellbeing in the perinatal period. Despite the recent interest both therapeutically and in research, to date no review has been published on self-compassion’s application to wellbeing in the perinatal period. The reviews findings suggest there is significant relationship between wellbeing and self-compassion in the perinatal period. Self-compassion interventions also showed good promise for a range of psychosocial outcomes.
Manche Kinder haben's gut, andere haben's besser: Die großen Unterschiede zwischen den Lebensbedingungen der Kinder
Creators: name: Wünsch, Susanne
name: Knappe, Eberhard
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: In unseren Nachrichten und Artikeln sind die problematischen Strukturen der vietnamesischen Gesellschaft immer wieder angeklungen. Die großen schnell wachsenden Städte, die der Motor des wirtschaftlichen Wachstums sind, haben eine große Anziehungskraft auch für Kinder und Jugendliche. Schon hier, in den urbanen Inseln gibt es große Unterschiede zwischen den Lebensbedingungen der Kinder aus eingesessenen Familien, die an Fortschritt und Wachstum partizipierend und gut versorgt leben können und denen, die sich allein oder mit weniger erfolgreichen Eltern durchs Leben schlagen.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 18 Nr. 3 (2002): Kindsköpfe: Kinder in Südostasien
Eine andere Historie – Frauen und die »Frühe Moderne«
Creators: name: Bey, Ulrike
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Buchbesprechung von: Barbara Watson Andaya (ed.), Other Pasts: Women, Gender and History in Early Modern Southeast Asia. Center for Southeast Asian Studies University of Hawai ’ i at Mânoa, Honolulu, 2000. ISBN 1-930734-00-X.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 18 Nr. 3 (2002): Kindsköpfe: Kinder in Südostasien
12 year follow up of enzyme-replacement therapy in two siblings with attenuated mucopolysaccharidosis I: the important role of early treatment
Creators: name: Gabrielli, Orazio
name: Clarke, Lorne A
name: Ficcadenti, Anna
name: Santoro, Lucia
name: Zampini, Lucia
name: Volpi, Nicola
name: Coppa, Giovanni V
Publisher: name: BioMed Central
Year: 2018

description: Background: Mucopolysaccharidosis type I is an autosomal recessive disorder caused by deficiency of α-L-iduronidase and characterized by a progressive course with multisystem involvement. Clinically, Mucopolysaccharidosis type I is classified into two forms: severe (Hurler syndrome), which presents in infancy and is characterized by rapid progressive neurological involvement and attenuated (Hurler/Scheie and Scheie syndromes), which presents with slower progression and absent to mild nervous system involvement. The specific treatment for attenuated Mucopolysaccharidosis type I consists of enzyme-replacement therapy with laronidase (human recombinant α-L-iduronidase, Aldurazyme). We present here the clinical and laboratory results in an 12-year-old patient affected by the attenuated form of Mucopolysaccharidosis type I treated by enzyme-replacement therapy from the age of 5 months, compared with his 17 year old affected sister, who started therapy at 5 years of age. Case Presentation: Clinical evaluation of these siblings shows that initiation of therapy prior of the onset of clinically detectable disease resulted in considerable improvement in outcome in the young sibling. After 12 years of enzyme-replacement therapy, facial appearance, linear growth rate, and liver and spleen volumes were normal; moreover, the degree of joint disease, vertebral, and cardiac valvular involvement were only minimal compared with those of his sister. Conclusion: This study demonstrates that early diagnosis and early initiation of enzyme-replacement therapy substantially modify the natural history of the attenuated form of Mucopolysaccharidosis type I.
Neue Tendenzen in der Sozialpolitik
Creators: name: Von Hauff, Michael
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Buchbesprechung von: Johannes Jäger, Gerhard Melinz, Susan Zimmermann (Hrsg.), Sozialpolitik in der Peripherie — Entwicklungsmuster und Wandel in Lateinamerika, Afrika, Asien und Osteuropa. 1. Auflage, Reihe Historische Sozialkunde 19/Internationale Entwicklung, Brandes & Apsel; Wien: Südwind, 2001, ISBN 3-86099-213-9.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 18 Nr. 3 (2002): Kindsköpfe: Kinder in Südostasien
Der Kindergipfel
Creators: name: Redaktion, Die
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Erstmals lud die UNO Kinder aus der ganzen Welt zum Kindergipfel. Ginge es nach ihnen, wären wir schon ein ganzes Stück weiter.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 18 Nr. 3 (2002): Kindsköpfe: Kinder in Südostasien
Startchancen: Mother Support — ein Ansatz für die besten Bedingungen der Entwicklung unserer Kinder
Creators: name: König, Thomas
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: »Die Global Initiative for Mother Support (GIMS) für das Stillen ist eine weltweite Initiative, die sich auf die Bereiche adäquate und wertfreie Information, Unterstützung in unterschiedlichen Lebensumständen und Gesundheitsversorgung für Frauen konzentriert. Hierbei richtet sich die Initiative in der Zeit vor, während und nach der Schwangerschaft nach den Bedürfnissen und den Rechten von Frauen. Die Initiative betrachtet in einem ganzheitlichen Ansatz den Reproduktionszyklus von Frauen und fördert unterschiedliche Methoden, um Müttern und ihren Kindern eine optimale Erfahrung durch das Stillen zu ermöglichen.«
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 18 Nr. 3 (2002): Kindsköpfe: Kinder in Südostasien
The role of three-body interactions on the equilibrium and non-equilibrium properties of fluids from molecular simulation
Creators: name: Marcelli, Gianluca
Publisher: name: Swinburne
Year: 2024

description: The aim of this work is to use molecular simulation to investigate the role of three-body interatomic potentials in noble gas systems for two distinct phenomena: phase equilibria and shear flow. In particular we studied the vapour-liquid coexisting phase for pure systems (argon, krypton and xenon) and for an argon-krypton mixture, utilizing the technique called Monte Carlo Gibbs ensemble. We also studied the dependence of the shear viscosity, pressure and energy with the strain rate in planar Couette flow, using a non-equilibrium molecular simulation (NEMD) technique. The results we present in this work demonstrate that three-body interactions play an important role in the overall interatomic interactions of noble gases. This is demonstrated by the good agreement between our simulation results and the experimental data for both equilibrium and non-equilibrium systems. The good results for vapour-liquid coexisting phases encourage performing further computer simulations with realistic potentials. This may improve the prediction of quantities like critical temperature and density, in particular of substances for which these properties are difficult to obtain from experiment. We have demonstrated that use of accurate two- and three-body potentials for shearing liquid argon and xenon displays significant departure from the expected strain rate dependencies of the pressure, energy and shear viscosity. For the first time, the pressure is convincingly observed to vary linearly with an apparent analytic y2 dependence, in contrast to the predicted y3/2 dependence of mode -coupling theory. Our best extrapolation of the zero -shear viscosity for argon gives excellent agreement (within 1%) with the known experimental data. To the best of our knowledge, this the first time that such accuracy has been achieved with NEMD simulations. This encourages performing simulations with accurate potentials for transport properties.
Relational Communication Style in Business, Marketing and Service Interactions
Creators: name: SCHERSCHEL, KATRIN
Publisher: name: University of Surrey
Year: 2022

description: Verbal communication (i.e. text or spoken language use) can be evaluated under two aspects, namely content and style. Thereby, communication style is independent of the content (what is conveyed) and consist of stylistic elements concerning how a sentence is expressed. This dissertation concentrates on three different aspects which influence how interactants communicate aka factors influencing communication style: (1) the relationship between interactants i.e. doctors and patients, (2) the interaction as a representation of a relationship i.e. marketing communication, and (3) individual differences i.e. empathy.
description: First, synthesizing marketing communication research in a meta-analytic review, shows that communication style in marketing can be summarized containing five dimensions, namely, arousal, composure, dominance, intimacy and task-orientation. The influence of the five communication styles on marketing outcomes, attitude, intention and behavior is established and boundary conditions are examined.
description: Second, the framework of communication styles deduced in the meta-analysis is used to examine how these dimensions influence perceptions of patients about their relationship with a health service professional. Using customer reviews of patients and exploiting text analysis to extract the dimensions in the verbatim review comments provides evidence for the dimensional structure of communication styles in doctor-patient relationships. Further, the individual and joint effects of the dimensions are linked to patient satisfaction.
description: Third, the concept of empathy, being a relevant variable in communication, is examined through bibliometric techniques. Applying bibliographic coupling shows that research on empathy in the business field is built on five clusters, two concept related clusters (perspective taking and empathic concern), and three content related clusters (ethics, sales and leadership). Content and co-word analysis provides additional insights, e.g. similarities or differences in conceptualization, definitions, keywords or methodologies, within and across clusters. Further, for all three topics regarded in this dissertation, research gaps are identified and translated into future research directions.
Investigating behaviours related to antibiotic use and exploring the viability of phage therapy as an alternative antimicrobial in UK companion animal medicine
Creators: name: GRIST, LUCY
Publisher: name: University of Surrey
Year: 2020

description: Antimicrobial resistance (AMR) is a significant threat to global health. Both human and veterinary medicine depend on the availability of effective antibiotics. With pets currently residing in nearly 50% of UK households, human and animal health are more closely connected than ever. A One Health approach that encourages prudent use of antibiotics, and development of alternatives, is of increasing importance and was adopted in this project to investigate the social, psychological and biological challenges of producing and implementing an alternative antimicrobial, phage therapy, into companion animal medicine.
description: Semi-structured interviews and thematic analyses were used to obtain vets and pet owners’ views and experiences of antibiotic use in pets. A quantitative survey involving 157 UK vets and pet owners was also developed to assess views on phage therapy and identify potential barriers to its implementation. Concurrently, laboratory studies were undertaken to find phage(s) appropriate for treating canine E. coli infections. Phage were isolated from environmental samples and screened for their ability to kill E. coli isolates found in canine wound and urinary tract infections. Promising candidates were characterised for their host range, burst size and stability.
description: Interviews with UK vets and pet owners revealed complexities in vet-owner interactions, including differing perceptions of responsibility for prudent antimicrobial use, suggesting that antibiotic use in companion animals is vulnerable to the same human behaviours as those seen in human medicine. We found that 71% of UK vets and pet owners were open to using phage therapy as an alternative antimicrobial to treat companion animals. Of 200 phages isolated from soil and sewage samples, five candidates were selected and showed varying degrees of lytic activity against E. coli. The most promising candidates were effective against four out of ten clinical isolates.
description: In conclusion, UK vets and pet owners displayed positive attitudes to alternative therapies, although larger scale surveys are needed to confirm this. Environmental samples were abundant in lytic phage; however, labour-intensive processing and limited host-ranges of selected phage highlighted the practical challenges associated with developing effective phage therapy treatments.
Autonomous Visual Inspection for generic defect detection in Nuclear Fusion Facilities
Creators: name: Skilton, Robert Mark
Publisher: name: University of Surrey
Year: 2023
Subjects: Anomaly
Defect
Robotic Inspection
Tokamak Maintenance
Visual Inspection

description: Nuclear fusion, the process that takes place in stars is a potentially game-changing source of low-carbon energy to meet future demands. It is, however, considerably challenging to sustain fusion reactions on earth. One of the critical barriers to the commercialisation of fusion energy being the ability to efficiently maintain and inspect fusion reactor systems.

description:

description: Detection of issues in plant is critical for both productivity, in terms of maximising up-time of plant, as well as for regulatory and safety related functions. Detection of general or unspecified anomalies in industrial environments using camera images is a challenging task, and one which is the focus of much current research.

description:

description: Many studies related to anomaly and defect detection are application focused, limiting wider applicability, and demonstrate results on domain-specific datasets which are often not widely available, and hence it is difficult to directly re-apply, or compare performance of new techniques.

description:

description: This work introduces the concept of Regenerative Anomaly Detection, whereby images taken in an environment are regenerated using a learned model of what the environment normally looks like, and the comparison of the two images is used as a metric of anomalousness. It explores the use of Generative Adversarial Networks (GAN)s, a deep learning-based architecture in performing generalised visual anomaly detection within the context of fusion remote maintenance. A framework for performing these operations and characterising performance is established.

description:

description: The work then focuses on three areas, where novel techniques are proposed and evaluated in order to improve capability in terms of performance through establishment of optimal image comparison metrics, combining techniques for selective in-component anomaly detection, and optimising image regeneration techniques by combining predictive and numerical approaches.

description:

description: Results and conclusions across all of these areas are presented, and then finally summarised, with a description of possible future directions of the work, and a discussion around links to other work including that in the worlds of perceptual and cognitive psychology.
Study of 208Po Populated via β+/EC Decay
Creators: name: BRUNET, MATTHEW HENRY
Publisher: name: University of Surrey
Year: 2021

description: Data collected during a decay spectroscopy experiment at the ISOLDE Decay Station (IDS) in 2016, were used to investigate the structure of 208Po populated via the β+/EC decay of 208At. This decay, and resulting structure, was most recently studied in experiments which took place in the 1980s. Thus, the aim of this analysis was to take advantage of improvements in detector technology and radioactive beam production to establish an expanded level scheme below QEC = 4999(9) keV. From this work a total of 170 transitions and 58 states were observed, including 27 newly-observed states. Ninety-three of the transitions identified in this analysis differ from prior decay studies. These consist of 43 newly-observed transitions; 33 previously-observed 208Po γ rays placed in the level scheme through this analysis; and 17 transitions moved from previous placements. Spin-parities were assigned through a combination of γ-ray placements, previously-measured αK values, and restrictions resulting from β and γ decay selection rules. In addition, electron conversion coefficients were calculated for all transitions below 1 MeV, and log ft values were determined for all populated states using intensity imbalances. From this analysis, ∼46% of the decays were found to be first-forbidden, a significant increase from the ∼37% measured in the 1980s. It is suggested that the high first-forbidden proportion of 208At and surrounding β+/EC-decaying nuclei could provide a testing ground for models of first-forbidden decay. These can then be incorporated into larger β-decay studies in the region which lack relevant data points, such as models of r-process nucleosynthesis. In addition, a low-lying 3− state at 1995 keV, which had been previously assigned (2−,3−), was identified. Through comparisons with shell model calculations and considering the underlying shell structure, it was concluded that the low energy of the state was the result of configuration mixing of an abundance of 3− states. In particular, the strength of f7/2i13/2 contributions to the octupole from both proton particle and neutron hole excitations results in stronger mixing for 3− states in 208Po with dominant f7/2i13/2 configurations. Strong octupole collectivity in the region, and observed, low-energy, core-excited states in neighbouring nuclei suggest collective character for the 1995 keV state. Although no evidence of this was found in this analysis, it is anticipated that a high statistics Coulex experiment could provide further detail into the nature of the 1995 keV state.
Literaturhinweise
Creators: name: Redaktion, Die
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 19 Nr. 1 (2003): GlobAlternativen? Fairer Handel und Verbraucherschutz in Südostasien
Impressum
Creators: name: Redaktion, Die
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 19 Nr. 1 (2003): GlobAlternativen? Fairer Handel und Verbraucherschutz in Südostasien
Neues aus dem Asienhaus
Creators: name: Redaktion, Die
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 19 Nr. 1 (2003): GlobAlternativen? Fairer Handel und Verbraucherschutz in Südostasien
»Fit for Fair«: Für menschenwürdige Arbeitsbedingungen in der weltweiten Sportartikel-Industrie!
Creators: name: Wieder, Karin
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Seit 1996 kämpft die deutsche Kampagne für 'Saubere' Kleidung für die Verbesserung der Arbeitsbedingungen in der weltweiten Bekleidungsindustrie. Sie unterstützt hierbei die bereits zwölfjährigen Aktivitäten der europaweiten Clean Clothes Campaign (CCC). Die CCC fordert die Umsetzung des von ihr erstellten Arbeitsverhaltenskodex' in den Zulieferbetrieben der europäischen Bekleidungsunternehmen sowie die externe Verifizierung dieser Umsetzung.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 19 Nr. 1 (2003): GlobAlternativen? Fairer Handel und Verbraucherschutz in Südostasien
Nachrichten
Creators: name: Aurin, Heike
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Nachrichten der Region.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 19 Nr. 1 (2003): GlobAlternativen? Fairer Handel und Verbraucherschutz in Südostasien
The Use of Virtual and Augmented Reality in Chemical Engineering Education
Creators: name: MOTEJLEK, JIRI
Publisher: name: University of Surrey
Year: 2022

description: Recent technological developments have allowed virtual reality (VR) to become more affordable and readily accessible within the gaming community, inspiring its use in other fields, including education. The use of VR in chemical engineering education provides a means for contextualising learning through authentic and engaging scenarios, e.g. the touring and operation of a chemical plant. Given the speed of progress of the field technical terms relating to VR are being misused and there are cases of a general misunderstanding about VR in the literature. To make the field more understandable and to make the meaning behind technical language clear a new taxonomy was developed using a rigorous methodology. The new taxonomy was used to structure a VR/AR application survey and to evaluate relevant applications and research articles in chemical engineering as well as in other disciplines where VR/AR is successfully used. With the goal of testing whether VR can be used as a training tool in chemical engineering, several prototypes were developed with different technological implementation considerations based on the new taxonomy. These findings, together with the technological limitations of the other prototypes, suggested that it is feasible to further develop one of the prototypes. The prototype developed to be used as a training tool in chemical engineering is a VR version of a chemical plant set up in the premises of the University of Surrey. Three studies were performed to assess the use of this VR version of the chemical plant on the main three educational areas outlined in the taxonomy: teaching, training and the motivational aspects of chemical engineering education. The VR learning resource was well received by the students. The results of this study confirm that it is possible to produce a VR experience that students find helpful and achieve a set of educational goals. The study provides evidence that teaching and training in a virtual plant using VR can be as effective as an experience received in a real plant, paving the way for the use of VR as a means of eliminating logistical, safety and other concerns of teaching and training chemical engineers and students on the real chemical plant. The methodological approach outlined in this thesis in creating the educational content allowed for such outcomes to be measurable.
Exploring the understanding and experience of cognitive impairment in chronic opiate users : an interpretative phenomenological analysis.
Creators: name: Bates, Sophie
Publisher: name: University of Surrey
Year: 2020

description: Introduction: Cognitive difficulties are evidenced in opiate-dependent populations, whether they are caused by drug use per se, or other associated life-style factors. To date no research exists which explores the subjective experience of cognitive impairment in opiate-dependent populations attending drug and alcohol services. In comparable fields such as brain injury and dementia, the subjective experience of cognitive impairment has been explored with important and beneficial results. Method: Using a qualitative design, data were collected from in-depth interviews with six working-age adults with a diagnosis of opiate-use disorder, attending a service for opiate-substitution therapy, who self-identified as experiencing memory and thinking difficulties. Transcripts were analysed in accordance with Interpretative Phenomenological Analysis. Results: Three superordinate themes emerged: “a damaged brain and mind” which included the extent of the impairment and how participants made sense of such difficulties; “perceptions of the self as spoiled” which explored the perceived changes in independence and dependence and resultant negative feelings about the self; and “coping with a lesser self” which included acceptance and adaptation, and familiar but maladaptive coping strategies. Conclusions: Participants’ understanding and experience of their cognitive difficulties contributed to their sense of well-being, and further impacted on chosen coping strategies. Consideration of cognitive impairment is important to effectively support individuals attending drug and alcohol services.
Beendet den Krieg in Mindanao! Ein Aufruf der Friedensinitiative Mindanao Peoples' Peace Movement
Creators: name: (Mindanao Peoples' Peace Movement), MPPM
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Die Mindanao Peoples' Peace Movement (MPPM), ein Zusammenschluss mehrerer Menschenrechts- und Friedensorganisationen, verurteilt die neuerliche Eskalation dieses Krieges, der Zentralmindanao weiter zerstört und viele Tausend Zivilist/innen aus ihren Häusern vertreibt.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 19 Nr. 1 (2003): GlobAlternativen? Fairer Handel und Verbraucherschutz in Südostasien
Alter Terror und neue Bomben: ln den Südphilippinen fordert »zweite Front gegen den Terror« immer mehr zivile Opfer
Creators: name: Werning, Rainer
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Die Regierung in Manila betreibt wie vor drei Jahren unter dem damaligen Präsidenten Joseph Estrada eine »Politik des totalen Krieges« gegen den Moro-Widerstand, um ihn militärisch zu brechen und ihm einen Diktatfrieden aufzuzwingen.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 19 Nr. 1 (2003): GlobAlternativen? Fairer Handel und Verbraucherschutz in Südostasien
title: CONSERVA Beiträge zur Erhaltung von Kunst- und Kulturgut, Nr. 1 (2003): Beiträge zur Erhaltung von Kunst- und Kulturgut
title: Beiträge zur Erhaltung von Kunst- und Kulturgut
titleType: AlternativeTitle
Creators: name: CONSERVA Beiträge Zur Erhaltung Von Kunst- Und Kulturgut
Publisher: name: CONSERVA Beiträge zur Erhaltung von Kunst- und Kulturgut
Year: 2025

description: Inhalt
Titelei
Das Kultbäumchen von Manching...74-79
Konsolidierung einer Malschicht mittels Aerosol in einem spätmittelalterlichen Büchsenmeisterbuch...129-135
Der doppelte Hitler...114-116
„Unter Dampf“...162-163
Die restauratorische und konservatorische Neubearbeitung einer Deichselzier aus Bronze...69-73
Die Bergung zweier frühneuzeitlicher Holzfragmente mittels Paraffin...94-96
Anschnürtechniken für lose Buchdeckel...121-128
Propulsion Airframe Integration: Aerodynamic Modeling of Boundary Layer Ingestion
Creators: name: KOB, LUCAS LEANDER
Publisher: name: University of Surrey
Year: 2022

description: "Propulsion airframe integration offers a range of benefits, while opening the realm of design options for future air-vehicle configurations. The aerodynamic complexity resulting from interaction between airframe and propulsion system, however, still lacks understanding. Current modeling approaches either neglect the aerodynamic interdependence by treating external vehicle aerodynamics and propulsion aerodynamics separately, or by applying non-valid assumptions on the behaviour of boundary layer during boundary layer ingestion (BLI). This work develops an aerodynamic modeling approach capable of accurately predicting the flow-field around a fully installed propulsion system, in-line of an axisymmetric body, ingesting its body boundary layer. This is accomplished by developing an empirical model of velocity component profiles at the fan inlet and exit which is then capable of delivering adaptive engine boundary conditions for CFD. The empirical model in turn is developed from experimental measurements. A low-cost modular experimental wind tunnel model is developed that allows for parametric investigation of various propulsion system shape variations. The experimentally generated flow-field data is then used for validation of CFD and the empirical model. Comparison between the experimentally generated data of the flow-field and surface pressures agrees well with CFD. A full net-thrust and drag prediction through a control volume analysis is performed and agrees well with experiment. This is evidence that accurate while efficient modeling of an air-vehicle configuration employing boundary layer ingestion is possible. Analysis of the boundary layer ingested showed that assessment of vorticity serves as a more accurate metric for definition of boundary layer edge than free stream velocity in these particular flow conditions. The presented modeling approach further highlights discrepancies between conventional modeling of boundary layer ingesting propulsion systems by comparison with the newly presented approach. Viscous body drag on the boat-tail upstream of the fan is thereby miscalculated by conventional methods by up to 8%; whereas pressure drag contributions are under-predicted by up to 28% for the cases compared. The numerical model is further coupled with a gradient based optimizer to showcase capability for shape and performance optimization. For the first time optimization for an installed BLI configuration with experimentally validated adaptive engine boundary conditions is presented."
Presente: Erinnerungen an Günter Reese
Creators: name: Schmidt, Klaus
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Unsere Wege kreuzten sich über 30 Jahre lang. In den 1970er Jahren arbeiteten wir redaktionell in einer gesellschaftskritischen Kirchenreform-Zeitschrift zusammen. Ich erzählte ihm von Vietnam-Demonstrationen und meinen Erfahrungen im Kölner Studentenpfarramt, er mir von den heftigen Reaktionen auf seinen Vorschlag, zwei Kirchengrundstücke zugunsten eines Dritte-Welt-Projektes von »Brot für die Welt« zu veräußern — wo doch Besitzstandswahrung in jeder Institution fast ein heiliges Prinzip ist!
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 19 Nr. 1 (2003): GlobAlternativen? Fairer Handel und Verbraucherschutz in Südostasien
Prevalence of alcohol and drug use in injured British Columbia drivers
Creators: name: Brubacher, Jeffrey
name: Chan, Herbert
name: Martz, Walter
name: Schreiber, William Edward, 1954-
name: Asbridge, Mark
name: Eppler, Jeffrey
name: Lund, Adam
name: Macdonald, Scott
name: Drummer, Olaf
name: Purssell, Roy
name: Andolfatto, Gary
name: Mann, Robert E.
name: Brant, Rollin
Publisher: name: BMJ Open
Year: 2022

description: Objectives: Determine the prevalence of drug use in injured drivers and identify associated demographic factors and crash characteristics. Design: Prospective cross-sectional study. Setting: Seven trauma centres in British Columbia, Canada (2010–2012). Participants: Automobile drivers who had blood obtained within 6 h of a crash. Main outcome measures: We analysed blood for cannabis, alcohol and other impairing drugs using liquid chromatography/mass spectrometry (LCMS). Results: 1097 drivers met inclusion criteria. 60% were aged 20–50 years, 63.2% were male and 29.0% were admitted to hospital. We found alcohol in 17.8% (15.6% to 20.1%) of drivers. Cannabis was the second most common recreational drug: cannabis metabolites were present in 12.6% (10.7% to 14.7%) of drivers and we detected Δ-9-tetrahydrocannabinol (Δ-9-THC) in 7.3% (5.9% to 9.0%), indicating recent use. Males and drivers aged under 30 years were most likely to use cannabis. We detected cocaine in 2.8% (2.0% to 4.0%) of drivers and amphetamines in 1.2% (0.7% to 2.0%). We also found medications including benzodiazepines (4.0% (2.9% to 5.3%)), antidepressants (6.5% (5.2% to 8.1%)) and diphenhydramine (4.7% (3.5% to 6.2%)). Drivers aged over 50 years and those requiring hospital admission were most likely to have used medications. Overall, 40.1% (37.2% to 43.0%) of drivers tested positive for alcohol or at least one impairing drug and 12.7% (10.7% to 14.7%) tested positive for more than one substance. Conclusions: Alcohol, cannabis and a broad range of other impairing drugs are commonly detected in injured drivers. Alcohol is well known to cause crashes, but further research is needed to determine the impact of other drug use, including drug–alcohol and drug–drug combinations, on crash risk. In particular, more work is needed to understand the role of medications in causing crashes to guide driver education programmes and improve public safety.
Im Zeichen des Carabao: Ein philippinisch-deutscher Nachruf auf Günter Reese (2.8.1939 - 28.12.02)
Creators: name: Hardillo, Mary Lou U.
name: Werning, Rainer
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Manila im Sommer 1977 — Barbosa Street — Quiapo. Ein quirliger Mikrokosmos des philippinischen Alltags. Hier befand sich das Domizil einer philippinischen NGO, die enge Bande zu bundesdeutschen — hauptsächlich kirchlich orientierten — Hilfswerken unterhielt, und mit deren Geschäftsführung ein Paar Kontakt pflegte, das wir ausgerechnet in der Barbosa Street kennen lernten — Anke und Günter Reese, sie rüstige Hausfrau, er promovierter Theologe.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 19 Nr. 1 (2003): GlobAlternativen? Fairer Handel und Verbraucherschutz in Südostasien
Predicting the aesthetic performance of web sites: what attracts people?
Creators: name: Haig, Andrew
name: Whitfield, Allan
Publisher: name: Swinburne
Year: 2024

description: This paper focuses upon the visual aesthetic performance of web sites. It describes an experiment in which a site, designed at three controlled levels of visual 'enrichment', was evaluated on a number of measures by two subject groups. The measures used represent the two main facets of the Categorical-Motivation model of aesthetics, and included others specific to the performance of web sites. Using Multidimensional Scaling the results were consistent with predictions derived from this model. They indicate that the drivers of site evaluation were primarily exploratory, 'collative ' variables representing 'interest', 'novelty ' and 'fun'.
Industrially relevant hydrolyzability and fermentability of sugarcane bagasse improved effectively by glycerol organosolv pretreatment
Creators: name: Sun, Fubao F
name: Zhao, Xiaoqin
name: Hong, Jiapeng
name: Tang, Yanjun
name: Wang, Liang
name: Sun, Haiyan
name: Li, Xiang
name: Hu, Jinguang
Publisher: name: BioMed Central
Year: 2016

description: Background: Previous work has demonstrated that glycerol organosolv pretreatment can effectively improve the hydrolyzability of various lignocellulosic substrates. This pretreatment process strategy is ideal to integrate a commercially successful lignocellulosic and vegetable oil biorefinery industry. However, industrially relevant high-solid-loading hydrolyzability and fermentability of the pretreated substrates have yet to be considered for enzyme-based lignocellulosic biorefineries. Results In this study, an AGO pretreatment of sugarcane bagasse was evaluated with regard to the component selectivity, structural modification, hydrolyzability, and fermentation of pretreated substrates. The results showed that the AGO pretreatment presented good component selectivity, removing approximately 70 % lignin and hemicellulose, respectively, from sugarcane bagasse with a near-intact preservation (94 %) of the overall cellulose. The pretreatment deconstructed the recalcitrant architecture of natural lignocellulosic biomass, thereby modifying the structure at the macro-/micrometer level (fiber size, surface area, average size, roughness) and supermolecular level (key chemical bond dissociation) of lignocellulosic substrates towards good hydrolyzability. Notably, extraordinarily few fermentation inhibitors (<0.2 g furfural and 5-hydromethyl furfural/kg feedstock) were generated from the AGO pretreatment process, which was apparently due to the prominent role of glycerol organic solvent in protecting monosaccharides against further degradation. The 72-h enzymatic hydrolysis of pretreated substrates at 15 % solid content achieved 90 % completion with Cellic CTec2 at 10 FPU/g dried substrate. With a simple nutrition (only 10 g/L (NH4)2SO4) addition, the fed-batch semi-SSF of AGO-pretreated substrates (30 % solid content) almost reached 50 g/L ethanol with cellulase preparation at 10 FPU/g dried substrate. These results have revealed that the pretreated substrate is susceptible and accessible to cellulase enzymes, thereafter exhibiting remarkable hydrolyzability and fermentability. Conclusion The AGO pretreatment is a promising candidate for the current pretreatment process towards industrially relevant enzyme-based lignocellulosic biorefineries.
HOX Genes in Endometrioid Ovarian Cancer
Creators: name: Idaikkadar, Praveena
Publisher: name: University of Surrey
Year: 2022

description: Ovarian cancer is often referred to as the “silent killer” and represents the number one cause of mortality from gynaecological malignancy in women in the United Kingdom. Endometrioid ovarian cancer (EnOC) is an uncommon subtype of epithelial ovarian cancer. HOX genes have an important role in embryogenesis and development, but their role in oncogenesis is an exciting and rapidly developing field. They have been studied in many types of solid organ and haematological malignancies, including some subtypes of ovarian cancer, but not in endometrioid ovarian cancer.

description:

description: This thesis shows that HOX genes are dysregulated in endometrioid ovarian cancer both at the cell line level and in a large cohort of patient tumours. Some HOX genes show heightened expression in cancerous tissue, such as HOX B5, and some HOX genes are downregulated such as HOX D10. This is proven at both an RNA level with PCR and also attempted at a protein level with IHC. However, there was no correlation between HOX gene expression and pathological or clinical variables such as stage, grade, time to progression or overall survival.

description:

description: This HOX gene dysregulation can be therapeutically targeted with drugs that block HOX gene function such as the peptide HXR9. In this Thesis it is shown that HXR9 is cytotoxic to EnOC cells with an IC50 of approximately 40μM and also works in synergy with platinum chemotherapy, enhancing the sensitivity of platinum resistant ovarian cancer cells and preventing colony formation.
Von schlecht zu echt schlecht (echt!): Die wirtschaftliche Entwicklung im Jahre 2002
Creators: name: Nicolas, Sandra
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Nach gut zwei Jahren mit einer Wirtschaftswissenschaftlerin als Präsidentin stehen die Philippinen vor Rekordarbeitslosenzahlen und einer gestiegenen Armutsquote.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 19 Nr. 1 (2003): GlobAlternativen? Fairer Handel und Verbraucherschutz in Südostasien
Straßenhändler in Existenznöten
Creators: name: Lopez, Bernardo V.
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: In der Mitte des vergangenen Jahres (2002) startete die Entwicklungsbehörde von Metro Manila (Metro Manlia Development Authority; MMDA) unter Führung von Bayani Fernando eine großangelegte Kampagne gegen Straßenhändler/innen. Kleine Verkaufsstände an den Straßen sollen verschwinden, um angeblich das Stadtbild zu verschönern und den Verkehr nicht mehr zu behindern. Die Behörden gehen dabei z.T. sehr brutal gegen die Kleinhändler/innen vor und brüsten sich stolz, wenn sie einige Straßenzüge erfolgreich 'gereinigt' haben.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 19 Nr. 1 (2003): GlobAlternativen? Fairer Handel und Verbraucherschutz in Südostasien
Faire Darlehen fördern nachhaltige Entwicklung: Oikocredit-Projekte in den Philippinen
Creators: name: Schwiederski, Christel
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Markt und Moral sind miteinander vereinbar, das war der Anspruch, als 1975 die internationale Ökumenische Entwicklungsgenossenschaft Oikocredit (damals EDCS) gegründet wurde. Die Strategie: Gelder, die die Oikocredit-Mitglieder anlegen, werden als faire, also langfristige und zins ­ günstige Kredite an Kooperativen in den armen Ländern vergeben. Damit will Oikocredit benachteiligten Menschen eine bessere Zukunft ermöglichen und nachhaltig Entwicklung fördern.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 19 Nr. 1 (2003): GlobAlternativen? Fairer Handel und Verbraucherschutz in Südostasien
Die Ressourcen der Armen: Nachhaltige Landnutzung in den Philippinen
Creators: name: Groll, Herwart
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Als die Grenzen und Kehrseiten der Grünen Revolution offensichtlich wurden, gründete sich MASIPAG — ein erfolgreiches Netzwerk der »Partnerschaft von Bauern und Wissenschaftlern für die Entwicklung« (d. Red.).
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 19 Nr. 1 (2003): GlobAlternativen? Fairer Handel und Verbraucherschutz in Südostasien
Zwischen Gewinnmaximierung und sozialer Verantwortung: Bananenanbau in den Philippinen
Creators: name: Ebert, Jochen
Publisher: name: südostasien – Zeitschrift für Politik • Kultur • Dialog
Year: 2018

description: Unter den Bananen produzierenden Ländern stehen die Philippinen an vierter Stelle hinter Ecuador, Costa Rica und Kolumbien. Für getrocknete Bananen besitzt das Land weltweit nahezu ein Liefermonopol.
description: südostasien – Zeitschrift für Politik • Kultur • Dialog, Bd. 19 Nr. 1 (2003): GlobAlternativen? Fairer Handel und Verbraucherschutz in Südostasien