cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A City-Scale ITS-G5 Network for Next-Generation Intelligent Transportation Systems: Design Insights and Challenges
Creators: name: Mavromatis, Ioannis
name: Tassi, Andrea
name: Piechocki, Robert J.
name: Nix, Andrew
Publisher: name: arXiv
Year: 2018
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: As we move towards autonomous vehicles, a reliable Vehicle-to-Everything (V2X) communication framework becomes of paramount importance. In this paper we present the development and the performance evaluation of a real-world vehicular networking testbed. Our testbed, deployed in the heart of the City of Bristol, UK, is able to exchange sensor data in a V2X manner. We will describe the testbed architecture and its operational modes. Then, we will provide some insight pertaining the firmware operating on the network devices. The system performance has been evaluated under a series of large-scale field trials, which have proven how our solution represents a low-cost high-quality framework for V2X communications. Our system managed to achieve high packet delivery ratios under different scenarios (urban, rural, highway) and for different locations around the city. We have also identified the instability of the packet transmission rate while using single-core devices, and we present some future directions that will address that.
description: Accepted for publication to AdHoc-Now 2018
Kernel-based quantum regressor models learn non-Markovianity
Creators: name: Tancara, Diego
name: Dinani, Hossein T.
name: Norambuena, Ariel
name: Fanchini, Felipe F.
name: Coto, Raúl
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences

description: Quantum machine learning is a growing research field that aims to perform machine learning tasks assisted by a quantum computer. Kernel-based quantum machine learning models are paradigmatic examples where the kernel involves quantum states, and the Gram matrix is calculated from the overlap between these states. With the kernel at hand, a regular machine learning model is used for the learning process. In this paper we investigate the quantum support vector machine and quantum kernel ridge models to predict the degree of non-Markovianity of a quantum system. We perform digital quantum simulation of amplitude damping and phase damping channels to create our quantum dataset. We elaborate on different kernel functions to map the data and kernel circuits to compute the overlap between quantum states. We show that our models deliver accurate predictions that are comparable with the fully classical models.
Caenorhabditis elegans: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification
Creators: name: Pak, Stephen C.
name: Pan, Xiaoping
name: Zhang, Baohong
name: Asch, Adam S.
name: Lee, Myon Hee
name: Kobet, Robert A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The nematode Caenorhabditis elegans (C. elegans) offers a unique opportunity for biological and basic medical researches due to its genetic tractability and well-defined developmental lineage. It also provides an exceptional model for genetic, molecular, and cellular analysis of human disease-related genes. Recently, C. elegans has been used as an ideal model for the identification and functional analysis of drugs (or small-molecules) in vivo. In this review, we describe conserved oncogenic signaling pathways (Wnt, Notch, and Ras) and their potential roles in the development of cancer stem cells. During C. elegans germline development, these signaling pathways regulate multiple cellular processes such as germline stem cell niche specification, germline stem cell maintenance, and germ cell fate specification. Therefore, the aberrant regulations of these signaling pathways can cause either loss of germline stem cells or overproliferation of a specific cell type, resulting in sterility. This sterility phenotype allows us to identify drugs that can modulate the oncogenic signaling pathways directly or indirectly through a high-throughput screening. Current in vivo or in vitro screening methods are largely focused on the specific core signaling components. However, this phenotype-based screening will identify drugs that possibly target upstream or downstream of core signaling pathways as well as exclude toxic effects. Although phenotype-based drug screening is ideal, the identification of drug targets is a major challenge. We here introduce a new technique, called Drug Affinity Responsive Target Stability (DARTS). This innovative method is able to identify the target of the identified drug. Importantly, signaling pathways and their regulators in C. elegans are highly conserved in most vertebrates, including humans. Therefore, C. elegans will provide a great opportunity to identify therapeutic drugs and their targets, as well as to understand mechanisms underlying the formation of cancer.
On Hopf algebras over basic Hopf algebras of dimension 24
Creators: name: Xiong, Rongchuan
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Algebra (math.QA)
subject: FOS: Mathematics

description: We determine finite-dimensional Hopf algebras over an algebraically closed field of characteristic zero, whose Hopf coradical is isomorphic to a non-pointed basic Hopf algebra of dimension $24$ and the infinitesimal braidings are indecomposable objects. In particular, we obtain families of new finite-dimensional Hopf algebras without the dual Chevalley property.
description: 22 pages
Lithium in Kepler Red Giants: Defining Normal and Anomalous
Creators: name: Tayar, Jamie
name: Carlberg, Joleen K.
name: Aguilera-Gómez, Claudia
name: Sayeed, Maryum
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The orders of magnitude variation in lithium abundances of evolved stars have long been a puzzle. Diluted signals, ambiguous evolutionary states and unknown masses have made it challenging to both map the expected lithium signals and explain the anomalously lithium-rich stars. We show here using a set of asteroseismically characterized evolved stars that the base lithium abundance in red giant stars is mass dependent, with higher mass stars having higher `normal' lithium abundances, while highly lithium enhanced stars may cluster around 0.8 or 1.8 M$_\odot$. We confirm previous studies that have shown that lithium enhancement and rapid rotation are often coincident, but find that the actual correlation between lithium abundance and the rotation rate, whether surface rotation, internal rotation, or radial differential rotation, is weak. Our data support previous assertions that most lithium rich giants are in the core-helium burning phase. We also note a tentative correlation between the highest lithium abundances and unusual carbon to nitrogen ratios, which is suggestive of binary interactions, though we find no simple correlation between lithium richness and indicators of binarity.
description: 19 pages, 9 figures, accepted for publication in AJ
Control of the magnetic phase coexistence in NdFe$_3$(BO$_3$)$_4$ by electric fields
Creators: name: Partzsch, S.
name: Hamann-Borrero, J. E.
name: Mazzoli, C.
name: Herrero-Martin, J.
name: Vasiliev, A.
name: Bezmaternykh, L.
name: Büchner, B.
name: Geck, J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We present a resonant x-ray diffraction study of the magnetic order in NdFe$_3$(BO$_3$)$_4$ and its coupling to applied electric fields. Our high-resolution measurements reveal A coexistence of two different magnetic phases, which can be triggered effectively by external electric fields. More in detail, the volume fraction of the collinear magnetic phase is found to strongly increase at the expense of helically ordered regions when an electric field is applied. These results confirm that the collinear magnetic phase is responsible for the ferroelectric polarization of NdFe$_3$(BO$_3$)$_4$ and, more importantly, demonstrate that magnetic phase coexistence provides an alternative route towards materials with a strong magnetoelectric response.
description: 5 pages, 3 figures
(102935) Minnie Lucretia Lloyd
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Electromagnetically induced transparency resonances inverted in magnetic field
Creators: name: Sargsyan, A.
name: Sarkisyan, D.
name: Pashayan-Leroy, Y.
name: Leroy, C.
name: Cartaleva, S.
name: Wilson-Gordon, A. D.
name: Auzinsh, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The electromagnetically induced transparency (EIT) phenomenon has been investigated in a $Λ$-system of the $^{87}$Rb D$_1$ line in an external transverse magnetic field. Two spectroscopic cells having strongly different values of the relaxation rates $γ_{rel}$ are used: a Rb cell with antirelaxation coating ($L\sim$1 cm) and a Rb nanometric-thin cell (nano-cell) with thickness of the atomic vapor column $L$=795nm. For the EIT in the nano-cell, we have the usual EIT resonances characterized by a reduction in the absorption (i.e. dark resonance (DR)), whereas for the EIT in the Rb cell with an antirelaxation coating, the resonances demonstrate an increase in the absorption (i.e. bright resonances). We suppose that such unusual behavior of the EIT resonances (i.e. the reversal of the sign from DR to BR) is caused by the influence of alignment process. The influence of alignment strongly depends on the configuration of the coupling and probe frequencies as well as on the configuration of the magnetic field.
description: 9 pages,23 figures
The kagomé metals RbTi$_3$Bi$_5$ and CsTi$_3$Bi$_5$
Creators: name: Werhahn, Dominik
name: Ortiz, Brenden R.
name: Hay, Aurland K.
name: Wilson, Stephen D.
name: Seshadri, Ram
name: Johrendt, Dirk
Publisher: name: arXiv
Year: 2022
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: The kagomé metals RbTi$_3$Bi$_5$ and CsTi$_3$Bi$_5$ were synthesized both as polycrystalline powders by heating the elements an argon atmosphere and as single crystals grown using a self-flux method. The compounds crystallize in the hexagonal crystal system isotypically to KV$_3$Sb$_5$ (P6/mmm, Z = 1, CsTi3Bi5: a = 5.7873(1) Å, c = 9.2062(1) Å; RbTi3Bi5: a = 5.773(1) Å, c = 9.065(1) Å). Titanium atoms form a kagomé net with bismuth atoms in the hexagons as well as above and below the triangles. The alkali metal atoms are coordinated by 12 bismuth atoms and form AlB$_2$-like slabs between the kagomé layers. Magnetic susceptibility measurements with CsTi$_3$Bi$_5$ and RbTi$_3$Bi$_5$ single crystals reveal Pauli-paramagnetism and traces of superconductivity caused by CsBi$_2$/RbBi$_2$ impurities. Magnetotransport measurements reveal conventional Fermi liquid behavior and quantum oscillations indicative of a single dominant orbit at low temperature. DFT calculations show the characteristic metallic kagomé band structure similar to that of CsV$_3$Sb$_5$ with reduced band filling. A symmetry analysis of the band structure does not reveal an obvious and unique signature of a nontrivial topology.
description: 20 pages, 5 Figures, submitted
Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and l-α-threofuranosyl ring systems: interactions with P2Y receptors
Creators: name: Herdewijn, Piet
name: Maddileti, Savitri
name: Vastmans, Karen
name: Kim, Hak Sung
name: Kempeneers, Veerle
name: Jacobson, Kenneth A.
name: Gao, Zhan Guo
name: Harden, T. Kendall
name: Costanzi, Stefano
name: Ohno, Michihiro
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: The ribose moiety of adenine nucleotide 3′,5′-bisphosphate antagonists of the P2Y1 receptor has been successfully substituted with a rigid methanocarba ring system, leading to the conclusion that the North (N) ring conformation is preferred in receptor binding. Similarly, at P2Y2 and P2Y4 receptors, nucleotides constrained in the (N) conformation interact equipotently with the corresponding ribosides. We now have synthesized and examined as P2Y receptor ligands nucleotide analogues substituted with two novel ring systems: (1) a (N) locked-carbocyclic (cLNA) derivative containing the oxabicyclo[2.2.1]heptane ring system and (2) L-α-threofuranosyl derivatives. We have also compared potencies and preferred conformations of these nucleotides with the known anhydrohexitol-containing P2Y1 receptor antagonist MRS2283. A cLNA bisphosphate derivative MRS2584 21 displayed a Ki value of 22.5nM in binding to the human P2Y1 receptor, and antagonized the stimulation of PLC by the potent P2Y1 receptor agonist 2-methylthio-ADP (30nM) with an IC50 of 650nM. The parent cLNA nucleoside bound only weakly to an adenosine receptor (A3). Thus, this ring system afforded some P2Y receptor selectivity. A L-α-threofuranosyl bisphosphate derivative 9 displayed an IC50 of 15.3μM for inhibition of 2-methylthio-ADP-stimulated PLC activity. L-α-Threofuranosyl-UTP 13 was a P2Y receptor agonist with a preference for P2Y2 (EC50 = 9.9μM) versus P2Y4 receptors. The P2Y1 receptor binding modes, including rotational angles, were estimated using molecular modeling and receptor docking.
Almost positive links are strongly quasipositive
Creators: name: Feller, Peter
name: Lewark, Lukas
name: Lobb, Andrew
Publisher: name: arXiv
Year: 2018
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 57M25

description: We prove that any link admitting a diagram with a single negative crossing is strongly quasipositive. This answers a question of Stoimenow's in the (strong) positive. As a second main result, we give simple and complete characterizations of link diagrams with quasipositive canonical surface (the surface produced by Seifert's algorithm). As applications, we determine which prime knots up to 13 crossings are strongly quasipositive, and we confirm the following conjecture for knots that have a canonical surface realizing their genus: a knot is strongly quasipositive if and only if the Bennequin inequality is an equality.
description: 25 pages, 11 figures, comments welcome! v2: Added applications: we determine which prime knots up to 13 crossings are strongly quasipositive, and we confirm the following conjecture for knots that have a canonical surface realizing their genus: a knot is strongly quasipositive iff the Bennequin inequality is an equality. v3: Some restructuring and added details. Accepted by Mathematische Annalen
(102934) Edith Emily Lloyd
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Documentation of wild edible fruits (WEFs) from mon District of Nagaland, India
Creators: name: Zenwang Konyak
Publisher: name: figshare
Year: 2020
Subjects: Botany

description: Mon District of Nagaland, India has tremendous potential in providing valuable Wild edible Fruits (WEFs) and very few works has been done on it. This paper deals with documentation of 65 species of WEFs belonging to 36 families and 51 genera. An attempt has been made to record the use of fruits and its treatment in various ailments. Besides medicinal values it also has high market values.
(102933) Charles Pepler Lloyd
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Anti-tumor agents 255: Novel glycyrrhetinic acid–dehydrozingerone conjugates as cytotoxic agents
Creators: name: Tatsuzaki, Jin
name: Itokawa, Hideji
name: Morris-Natschke, Susan L.
name: Lee, Kuo Hsiung
name: Nakagawa-Goto, Kyoko
name: Taniguchi, Masahiko
name: Baba, Kimiye
name: Bastow, Kenneth F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Esterification of glycyrrhetinic acid (GA) with dehydrozingerone (DZ) resulted in a novel cytotoxic GA-DZ conjugate. Based on this exciting finding, we conjugated eleven different DZ analogs with GA or other triterpenoids, including oleanoic acid (OA) or ursolic acid (UA). In an in vitro anticancer assay using nine different human tumor cell lines, most of the GA-DZ conjugates showed significant potency. Particularly, compounds 5, 29, and 30 showed significant cytotoxic effects against LN-Cap, 1A9, and KB cells with ED50 values of 0.6, 0.8, and 0.9 μM, respectively. Similar conjugates between DZ and OA or UA were inactive suggesting that the GA component is critical for activity. Notably, although GA-DZ conjugates showed potent cytotoxic activity, the individual components (GA and DZ analogs) were inactive. Thus, GA-DZ conjugates are new chemical entities and represent interesting hits for anticancer drug discovery and development.
Controlling and scripting laboratory hardware with open-source, intuitive interfaces: OpenFlexure Voice Control and OpenFlexure Blockly
Creators: name: McDermott, Samuel
name: Bowman, Richard
name: Harrington, Kerrianne
name: Wadsworth, William
name: Cicuta, Pietro
Publisher: name: arXiv
Year: 2022
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Human-Computer Interaction (cs.HC)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Making user interaction with laboratory equipment more convenient and intuitive should promote experimental work and help researchers to complete their tasks efficiently. The most common form of interaction in current instrumentation is either direct tactile, with buttons and knobs, or interfaced through a computer, using a mouse and keyboard. Scripting is another function typical of smart and automated laboratory equipment, yet users are currently required to learn bespoke programming languages and libraries for individual pieces of equipment. In this paper, we present two open-source, novel and intuitive ways of interacting with and scripting laboratory equipment. We choose the OpenFlexure family of microscopes as our exemplar, due to their open-source nature and smart control system. Firstly, we demonstrate 'OpenFlexure Voice Control' to enable users to control the microscope hands-free. Secondly, we present 'OpenFlexure Blockly' which uses the Blockly Visual Programming Language to enable users to easily create scripts for the microscope, using a drag and drop web interface. We explain the design choices when developing these tools, and discuss more typical use cases and more general applications.
Poster: Parallel Implementation of the OMNeT++ INET Framework for V2X Communications
Creators: name: Mavromatis, Ioannis
name: Tassi, Andrea
name: Piechocki, Robert J.
name: Nix, Andrew
Publisher: name: arXiv
Year: 2018
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: The field of parallel network simulation frameworks is evolving at a great pace. That is also because of the growth of Intelligent Transportation Systems (ITS) and the necessity for cost-effective large-scale trials. In this contribution, we will focus on the INET Framework and how we re-factor its single-thread code to make it run in a multi-thread fashion. Our parallel version of the INET Framework can significantly reduce the computation time in city-scale scenarios, and it is completely transparent to the user. When tested in different configurations, our version of INET ensures a reduction in the computation time of up to 43%.
description: Accepted for publication to IEEE VNC 2018
Crystal structure of the PXR–T1317 complex provides a scaffold to examine the potential for receptor antagonism
Creators: name: Willson, Timothy M.
name: Collins, Jon L.
name: Zuercher, William J.
name: Xue, Yu
name: Redinbo, Matthew R.
name: Chao, Esther
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: The human pregnane X receptor (PXR) recognizes a range of structurally- and chemically-distinct ligands and plays a key role in regulating the expression of protective gene products involved in the metabolism and excretion of potentially harmful compounds. The identification and development of PXR antagonists is desirable as a potential way to control the up-regulation of drug metabolism pathways during the therapeutic treatment of disease. We present the 2.8 Å resolution crystal structure of the PXR ligand binding domain (LBD) in complex with T0901317 (T1317), which is also an agonist of another member of the orphan class of the nuclear receptor superfamily, the liver X receptor (LXR). In spite of differences in the size and shape of the receptors' ligand binding pockets, key interactions with this ligand are conserved between human PXR and human LXR. Based on the PXR-T1317 structure, analogues of T1317 were generated with the goal of designing an PXR antagonist effective via the receptor's ligand binding pocket. We find that selectivity in activating PXR vs. LXR was achieved; such compounds may be useful in addressing neurodegenerative diseases like Niemann-Pick C. We were not successful, however, in producing a PXR antagonist. Based on these observations, we conclude that the generation of PXR antagonists targeted to the ligand binding pocket may be difficult due to the promiscuity and structural conformability of this xenobiotic sensor.
(102932) Jessie Louisa Lloyd
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The effects of Coulomb interactions on the superconducting gaps in iron-based superconductors
Creators: name: Leong, Zhidong
name: Phillips, Philip
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Recent angle-resolved photoemission spectroscopy measurements of Co-doped LiFeAs report a large and robust superconducting gap on the $Γ$-centered hole band that lies 8 meV below the Fermi level. We show that, unlike a conventional superconductor described by BCS theory, a multiband system with strong interband Coulomb interactions can explain these observations. We model LiFeAs with a five-band model in which the shallow hole band is coupled with the other bands by only Coulomb interactions. Using Eliashberg theory, we find reasonable interaction parameters that reproduce the $T_c$ and all five gaps of LiFeAs. The energy independence of the Coulomb interactions then ensures the robustness of the gap induced on the shallow band. Furthermore, due to the repulsive nature of the Coulomb interactions, the gap changes sign between the shallow band and the other hole pockets, corresponding to an unconventional $s_{\pm}$ gap symmetry. Unlike other families of iron-based superconductors, the gap symmetry of LiFeAs has not been ascertained experimentally. The experimental implications of this sign-changing state are discussed.
description: 6 pages, 5 figures
Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-Chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one
Creators: name: Altundas, Ramazan
name: Suresh Kumar, Eyunni V.K.
name: Khan, Abdul
name: Roth, Bryan L.
name: Ablordeppey, Seth Y.
name: Zhu, Xue Y.
name: Bricker, Barbara
name: Jackson, Tanise
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The synthesis and exploration of novel butyrophenones have led to the identification of a diazepane analog of haloperidol, 4-[4-(4-Chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one (Compound 13) with an interesting multireceptor binding profile. Compound 13 was evaluated for its binding affinities at DA subtype receptors, 5HT subtype receptors, H-1, M-1 receptors and at NET, DAT and SERT transporters. At each of these receptors, compound 13 was equipotent or better than several of the standards currently in use. In in vivo mouse and rat models to evaluate its efficacy and propensity to elicit catalepsy and hence EPS in humans, compound 13 showed similar efficacy as clozapine and did not produce catalepsy at five times its ED50 value.
Zenwang & Phongle 8-5-18-271 (1).pdf
Creators: name: Zenwang Konyak
Publisher: name: figshare
Year: 2020
Subjects: Botany

description: Mon District of Nagaland, India has tremendous potential in providing valuable Wild edible Fruits (WEFs) and very few works has been done on it. This paper deals with documentation of 65 species of WEFs belonging to 36 families and 51 genera. An attempt has been made to record the use of fruits and its treatment in various ailments. Besides medicinal values it also has high market values.
(102931) Florence Bessie Lloyd
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists
Creators: name: Cosyn, Liesbet
name: de Castro, Sonia
name: Grifantini, Mario
name: Van Calenbergh, Serge
name: Harden, T. Kendall
name: Ko, Hyojin
name: Zhou, Yixing
name: Besada, Pedro
name: Cappellacci, Loredana
name: Carter, Rhonda L.
name: Jacobson, Kenneth A.
name: Petrelli, Riccardo
name: Franchetti, Palmarisa
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The phosphate, uracil, and ribose moieties of uracil nucleotides were varied structurally for evaluation of agonist activity at the human P2Y2, P2Y4, and P2Y6 receptors. The 2-thio modification, found previously to enhance P2Y2 receptor potency, could be combined with other favorable modifications to produce novel molecules that exhibit high potencies and receptor selectivities. Phosphonomethylene bridges introduced for stability in analogues of UDP, UTP and uracil dinucleotides markedly reduced potency. Truncation of dinucleotide agonists of the P2Y2 receptor, in the form of Up4-sugars, indicated that a terminal uracil ring is not essential for moderate potency at this receptor and that specific SAR patterns are observed at this distal end of the molecule. Key compounds reported in this study include: 9, α,β-methylene-UDP, a P2Y6 receptor agonist; 30, Up4-phenyl ester and 34, Up4-[1]glucose, selective P2Y2 receptor agonists; 43, the 2-thio analogue of INS37217 (P1-(uridine 5′)-P4- (2′-deoxycytidine 5′) tetraphosphate), a potent and selective P2Y2 receptor agonist.
(102930) Emma Gardler
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Synthesis and proteasome inhibition of glycyrrhetinic acid derivatives
Creators: name: Yu, Donglei
name: Ho, Phong
name: Lee, Kuo Hsiung
name: Chen, Chin Ho
name: Huang, Li
name: Qian, Keduo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: This study discovered that glycyrrhetinic acid inhibited the human 20S proteasome at 22.3 µM. Esterification of the C-3 hydroxyl group on glycyrrhetinic acid with various carboxylic acid reagents yielded a series of analogs with marked improved potency. Among the derivatives, glycyrrhetinic acid 3-O-isophthalate (17) was the most potent compound with IC50 of 0.22 µM, which was approximately 100-fold more potent than glycyrrhetinic acid.
Total synthesis of phenanthroindolizidine alkaloids (±)-antofine, (±)-deoxypergularinine, and their dehydro congeners and evaluation of their cytotoxic activity
Creators: name: Bastow, Kenneth F.
name: Su, Chung Ren
name: Lee, Kuo Hsiung
name: Wu, Tian Shung
name: Damu, Amooru G.
name: Chiang, Po Cheng
name: Morris-Natschke, Susan L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Due to their limited natural abundance and significant biochemical effects, we synthesized the alkaloids (±)-antofine (1a), (±)-deoxypergularinine (1b), and their dehydro congeners (2 and 3) starting from the corresponding phenanthrene-9-carboxaldehydes. We also evaluated their in vitro cytotoxic activity. Compounds 1a and 1b showed significant potency against various human tumor cell lines, including a drug-resistant variant, with EC50 values ranging from 0.16–16 ng/mL. Structure–activity correlations of these alkaloids and some of their synthetic intermediates were also ascertained. The non-planar structure between the two major moieties, phenanthrene and indolizidine, plays a crucial role in the cytotoxic activity of phenanthroindolizidines. Increasing the planarity and rigidity of the indolizidine moiety significantly reduced potency. A methoxy group at the 2-position (1a) was more favorable for cytotoxic activity than a hydrogen atom (1b).
UV Spectral Characterization of Low-Mass Stars With AstroSat UVIT for Exoplanet Applications: The Case Study of HIP 23309
Creators: name: Ranjan, Sukrit
name: Nayak, Prasanta K.
name: Pineda, J. Sebastian
name: Narang, Mayank
Publisher: name: arXiv
Year: 2023
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Characterizing rocky exoplanet atmospheres is a key goal of exoplanet science, but interpreting such observations will require understanding the stellar UV irradiation incident on the planet from its host star. Stellar UV mediates atmospheric escape, photochemistry, and planetary habitability, and observations of rocky exoplanets can only be understood in the context of the UV SED of their host stars. Particularly important are SEDs from observationally favorable but poorly understood low-mass M-dwarf stars, which are the only plausible targets for rocky planet atmospheric characterization for the next 1-2 decades. In this work, we explore the utility of AstroSat UVIT for the characterization of the UV SEDs of low-mass stars. We present observations of the nearby M0 star HIP 23309 in the FUV and NUV gratings of UVIT. Our FUV spectra are consistent with contemporaneous HST data and our NUV spectra are stable between orbits, suggesting UVIT is a viable tool for the characterization of the SEDs of low-mass stars. We apply our measured spectra to simulations of photochemistry and habitability for a hypothetical rocky planet orbiting HIP 23309 and elucidate the utility and limitations of UVIT in deriving UV SEDs of M-dwarf exoplanet hosts. Our work validates UVIT as a tool to complement HST in the characterization of exoplanet host stars and carries implications for its successor missions like INSIST.
description: Accepted to AJ
Four dimensional gravity as an almost Poisson system
Creators: name: Ita, Eyo E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this paper we examine the phase space structure of a noncanonical formulation of 4-dimensional gravity referred to as the Instanton representation of Plebanski gravity (IRPG). The typical Hamiltonian (symplectic) approach leads to an obstruction to the definition of a symplectic structure on the full phase space of the IRPG. We circumvent this obstruction, using the Lagrange equations of motion, to find the appropriate generalization of the Poisson bracket. It is shown that the IRPG does not support a Poisson bracket except on the vector constraint surface. Yet there exists a fundamental bilinear operation on its phase space which produces the correct equations of motion and induces the correct transformation properties of the basic fields. This bilinear operation is known as the almost-Poisson bracket, which fails to satisfy the Jacobi identity and in this case also the condition of antisymmetry. We place these results into the overall context of nonsymplectic systems.
description: 19 pages
Domain wall melting across a defect
Creators: name: Capizzi, Luca
name: Scopa, Stefano
name: Rottoli, Federico
name: Calabrese, Pasquale
Publisher: name: arXiv
Year: 2022
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We study the melting of a domain wall in a free-fermionic chain with a localised impurity. We find that the defect enhances quantum correlations in such a way that even the smallest scatterer leads to a linear growth of the entanglement entropy contrasting the logarithmic behaviour in the clean system. Exploiting the hydrodynamic approach and the quasiparticle picture, we provide exact predictions for the evolution of the entanglement entropy for arbitrary bipartitions. In particular, the steady production of pairs at the defect gives rise to non-local correlations among distant points. We also characterise the subleading logarithmic corrections, highlighting some universal features.
description: 6 pages, 6 figures
(102929) Josiah Hall
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Molecular recognition in the P2Y14 receptor: Probing the structurally permissive terminal sugar moiety of uridine-5′-diphosphoglucose
Creators: name: Kirk, Kenneth L.
name: Ko, Hyojin
name: Hajduch, Jan
name: Ivanov, Andrei A.
name: Melman, Artem
name: Das, Arijit
name: Kováč, Pavol
name: Zhou, Yixing
name: Carter, Rhonda L.
name: Fricks, Ingrid P.
name: Harden, T. Kendall
name: Joshi, Bhalchandra V.
name: Jacobson, Kenneth A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The P2Y14 receptor, a nucleotide signaling protein, is activated by uridine-5′-diphosphoglucose 1 and other uracil nucleotides. We have determined that the glucose moiety of 1 is the most structurally permissive region for designing analogues of this P2Y14 agonist. For example, the carboxylate group of uridine-5′-diphosphoglucuronic acid proved to be suitable for flexible substitution by chain extension through an amide linkage. Functionalized congeners containing terminal 2-acylaminoethylamides prepared by this stratgegy retained P2Y14 activity, and molecular modeling predicted close proximity of this chain to the 2nd extracellular loop of the receptor. In addition, replacement of glucose with other sugars did not diminish P2Y14 potency. For example, the [5″]ribose derivative had an EC50 of 0.24 μM. Selective monofluorination of the glucose moiety indicated a role for the 2″- and 6″-hydroxyl groups of 1 in receptor recognition. The β-glucoside was 2-fold less potent than the native α-isomer, but methylene replacement of the 1″-oxygen abolished activity. Replacement of the ribose ring system with cyclopentyl or rigid bicyclo[3.1.0]hexane groups abolished activity. Uridine-5′-diphosphoglucose also activates the P2Y2 receptor, but the 2-thio analogue and several of the potent modified-glucose analogues were P2Y14-selective.
Reconstruction of nuclear quadrupole interaction in (In,Ga)As/GaAs quantum dots observed by transmission electron microscopy
Creators: name: Sokolov, P. S.
name: Petrov, M. Yu.
name: Mehrtens, T.
name: Müller-Caspary, K.
name: Rosenauer, A.
name: Reuter, D.
name: Wieck, A. D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: A microscopic study of the individual annealed (In,Ga)As/GaAs quantum dots is done by means of high-resolution transmission electron microscopy. The Cauchy-Green strain-tensor component distribution and the chemical composition of the (In,Ga)As alloy are extracted from the microscopy images. The image processing allows for the reconstruction of the strain-induced electric-field gradients at the individual atomic columns extracting thereby the magnitude and asymmetry parameter of the nuclear quadrupole interaction. Nuclear magnetic resonance absorption spectra are analyzed for parallel and transverse mutual orientations of the electric-field gradient and a static magnetic field.
description: 8 pages, 6 figures
IR-MCL: Implicit Representation-Based Online Global Localization
Creators: name: Kuang, Haofei
name: Chen, Xieyuanli
name: Guadagnino, Tiziano
name: Zimmerman, Nicky
name: Behley, Jens
name: Stachniss, Cyrill
Publisher: name: arXiv
Year: 2022
Subjects: subject: Robotics (cs.RO)
subject: Artificial Intelligence (cs.AI)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Determining the state of a mobile robot is an essential building block of robot navigation systems. In this paper, we address the problem of estimating the robots pose in an indoor environment using 2D LiDAR data and investigate how modern environment models can improve gold standard Monte-Carlo localization (MCL) systems. We propose a neural occupancy field to implicitly represent the scene using a neural network. With the pretrained network, we can synthesize 2D LiDAR scans for an arbitrary robot pose through volume rendering. Based on the implicit representation, we can obtain the similarity between a synthesized and actual scan as an observation model and integrate it into an MCL system to perform accurate localization. We evaluate our approach on self-recorded datasets and three publicly available ones. We show that we can accurately and efficiently localize a robot using our approach surpassing the localization performance of state-of-the-art methods. The experiments suggest that the presented implicit representation is able to predict more accurate 2D LiDAR scans leading to an improved observation model for our particle filter-based localization. The code of our approach will be available at: https://github.com/PRBonn/ir-mcl.
description: 8 pages, 5 figures. Accepted to IEEE Robotics and Automation Letters
The Path to Digital Transformation in Nigerian Higher Education
Creators: name: Muoka, Chibuzor
Publisher: name: Zenodo
Year: 2024

description: This paper examines the urgent need for digital transformation in Nigerian higher education. While global advancements in technology have revolutionized education, many Nigerian universities remain anchored in outdated practices, hindering progress. The concept of a "digital city"—where technology permeates all aspects of academic life—is essential for these institutions to thrive in the 21st century. Key reforms include infrastructural upgrades, such as renewable energy and reliable internet, as well as smart services like digital student ID cards and e-assessment platforms. Overcoming technophobia and fostering collaborations between university management, government, and international partners is crucial. Embracing digitalization will enable Nigerian universities to compete globally and offer a modern, technology-driven learning environment.
(102927) Horace Hall
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(102926) Geoffrey Lloyd
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Topology vs localization in synthetic dimensions
Creators: name: Monaco, Domenico
name: Roussigné, Thaddeus
Publisher: name: arXiv
Year: 2022
Subjects: subject: Mathematical Physics (math-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences
subject: 81-06, 81V70

description: Motivated by recent developments in quantum simulation of synthetic dimensions, e.g. in optical lattices of ultracold atoms, we discuss here $d$-dimensional periodic, gapped quantum systems for $d \le 4$, with focus on the topology of the occupied energy states. We perform this analysis by asking whether the spectral subspace below the gap can be spanned by smooth and periodic Bloch functions, corresponding to localized Wannier functions in position space. By constructing these Bloch functions inductively in the dimension, we show that if they are required to be orthonormal then in general their existence is obstructed by the first two Chern classes of the underlying Bloch bundle, with the second Chern class characterizing in particular the 4-dimensional situation. If the orthonormality constraint is relaxed, we show how $m$ occupied energy bands can be spanned by a Parseval frame comprising at most $m+2$ Bloch functions.
description: 26 pages, 3 figures. Submission for the JMP special topic 'Mathematical aspects of topological phases'. Proceedings volume for the conference 'Topological phases of matter', Leysin (CH), July 25-28, 2021. v1-->v2: small changes, matches published version
Additional file 1 of Evaluation of dyspnea of unknown etiology in HIV patients with cardiopulmonary exercise testing and cardiovascular magnetic resonance imaging
Creators: name: Patterson, Andrew J.
name: Sarode, Anuja
name: Sadeer Al-Kindi
name: Shaver, Lauren
name: Thomas, Rahul
name: Watson, Evelyn
name: Alaiti, Mohamad Amer
name: Yuchi Liu
name: Hamilton, Jessie
name: Seiberlich, Nicole
name: Rashid, Imran
name: Gilkeson, Robert
name: Schilz, Robert
name: Hoit, Brian
name: Jenkins, Trevor
name: Zullo, Melissa
name: Bossone, Eduardo
name: Longenecker, Christopher
name: Simonetti, Orlando
name: Rajagopalan, Sanjay
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 60506 Virology

description: Additional file 1 Figure S1 Bland Altman analysis of right ventricular ejection fraction (RVEF) and left ventricular ejection fraction (LVEF) contractile reserve.