title: Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¾Ð¿ÑÐ¸Ð¼Ð°Ð»ÑÐ½ÑÑ ÑÐµÐ¶Ð¸Ð¼Ð¾Ð² HIFU-Ð°Ð±Ð»ÑÑÐ¸Ð¸ Ð½Ð° Ð¼Ð¾Ð´ÐµÐ»ÑÑ Ð¿ÐµÑÐµÐ²Ð¸Ð²Ð°ÐµÐ¼ÑÑ Ð¾Ð¿ÑÑ Ð¾Ð»ÐµÐ¹ Ñ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÑ Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÑ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Development of optimal HIFU ablation regimes on transplantable tumour models in experimental animals
Creators: name: ÐÑÐ¼Ð°ÐºÐ¾Ð²Ð°, ÐÐ»ÐµÐ½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: Ð²ÑÑÐ¾ÐºÐ¾Ð¸Ð½ÑÐµÐ½ÑÐ¸Ð²Ð½ÑÐ¹ ÑÑÐ¾ÐºÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐ¹ ÑÐ»ÑÑÑÐ°Ð·Ð²ÑÐº (HIFU)
Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð¾Ð¿ÑÑ Ð¾Ð»ÐµÐ²Ð¾Ðµ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ
Ð·Ð»Ð¾ÐºÐ°ÑÐµÑÑÐ²ÐµÐ½Ð½ÑÐµ Ð½Ð¾Ð²Ð¾Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ñ
Ð´Ð¾Ð±ÑÐ¾ÐºÐ°ÑÐµÑÑÐ²ÐµÐ½Ð½ÑÐµ Ð¾Ð¿ÑÑ Ð¾Ð»Ð¸
Ð¾Ð¿ÑÑ Ð¾Ð»Ñ Ð­ÑÐ»Ð¸Ñ Ð°
Ð½ÐµÐ¸Ð½Ð²Ð°Ð·Ð¸Ð²Ð½ÑÐµ Ð¼ÐµÑÐ¾Ð´Ñ
high-intensity focused ultrasound (HIFU)
antitumour activity
malignant tumours
benign tumours
Ehrlich tumour
non-invasive methods

description: ÐÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð½Ð° ÑÐµÐ¼Ñ Â«Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¾Ð¿ÑÐ¸Ð¼Ð°Ð»ÑÐ½ÑÑ ÑÐµÐ¶Ð¸Ð¼Ð¾Ð² HIFU-Ð°Ð±Ð»ÑÑÐ¸Ð¸ Ð½Ð° Ð¼Ð¾Ð´ÐµÐ»ÑÑ Ð¿ÐµÑÐµÐ²Ð¸Ð²Ð°ÐµÐ¼ÑÑ Ð¾Ð¿ÑÑÐ¾Ð»ÐµÐ¹ Ñ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÑ Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÑÂ» Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐµ ÑÑÑÐµÐºÑÐ¸Ð²Ð½ÑÑ Ð¸ Ð±ÐµÐ·Ð¾Ð¿Ð°ÑÐ½ÑÑ ÑÐµÐ¶Ð¸Ð¼Ð¾Ð² HIFU Ð°Ð±Ð»ÑÑÐ¸Ð¸ Ð½Ð° Ð¼Ð¾Ð´ÐµÐ»ÑÑ Ð¿ÐµÑÐµÐ²Ð¸Ð²Ð°ÐµÐ¼ÑÑ Ð¾Ð¿ÑÑÐ¾Ð»ÐµÐ¹ Ñ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÑ Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÑ Ñ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸ÐµÐ¼ Ð¾Ð¿ÑÑÐ½Ð¾Ð³Ð¾ Ð¾Ð±ÑÐ°Ð·ÑÐ° Ð¼ÐµÐ´Ð¸ÑÐ¸Ð½ÑÐºÐ¾Ð³Ð¾ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ° Â«ÐÐÐÐ¢ÐÐ Â». Ð­ÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½Ð°Ñ ÑÐ°ÑÑÑ ÑÐ°Ð±Ð¾ÑÑ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð° Ð² Ð½Ð°ÑÑÐ½Ð¾Ð¹ Ð»Ð°Ð±Ð¾ÑÐ°ÑÐ¾ÑÐ¸Ð¸ ÑÐ¸Ð¼Ð¸Ð¾Ð¿ÑÐ¾ÑÐ¸Ð»Ð°ÐºÑÐ¸ÐºÐ¸ ÑÐ°ÐºÐ° Ð¸ Ð¾Ð½ÐºÐ¾ÑÐ°ÑÐ¼Ð°ÐºÐ¾Ð»Ð¾Ð³Ð¸Ð¸ Ð¤ÐÐÐ£ Â«ÐÐÐÐ¦ Ð¾Ð½ÐºÐ¾Ð»Ð¾Ð³Ð¸Ð¸ Ð¸Ð¼. Ð.Ð. ÐÐµÑÑÐ¾Ð²Ð°Â» ÐÐ¸Ð½Ð·Ð´ÑÐ°Ð²Ð° Ð Ð¾ÑÑÐ¸Ð¸ (Ð·Ð°Ð²ÐµÐ´ÑÑÑÐ¸Ð¹ Ð½Ð°ÑÑÐ½Ð¾Ð¹ Ð»Ð°Ð±Ð¾ÑÐ°ÑÐ¾ÑÐ¸ÐµÐ¹ â Ð´.Ð¼.Ð½., Ð´Ð¾ÑÐµÐ½Ñ ÐÐµÑÐ¿Ð°Ð»Ð¾Ð² Ð.Ð.). Ð­ÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÑ, Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸Ð¼ÑÐµ Ð½Ð° Ð»Ð°Ð±Ð¾ÑÐ°ÑÐ¾ÑÐ½ÑÑ Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÑ (Ð¼ÑÑÐ¸ Ð¸ ÐºÑÑÑÑ), Ð²ÐºÐ»ÑÑÐ°Ð»Ð¸: Ð¾ÑÑÐ°Ð±Ð¾ÑÐºÑ Ð¾Ð¿ÑÐ¸Ð¼Ð°Ð»ÑÐ½ÑÑ Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÐ¾Ð² Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¸Ñ Ð°Ð±Ð»ÑÑÐ¸Ð¸ Ð²ÑÑÐ¾ÐºÐ¾Ð¸Ð½ÑÐµÐ½ÑÐ¸Ð²Ð½ÑÐ¼ ÑÑÐ¾ÐºÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐ¼ ÑÐ»ÑÑÑÐ°Ð·Ð²ÑÐºÐ¾Ð¼ (High Intensity Focused Ultrasound, HIFU); Ð¼Ð¾ÑÑÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÑÑ Ð¾ÑÐµÐ½ÐºÑ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð²ÑÐ±ÑÐ°Ð½Ð½Ð¾Ð³Ð¾ ÑÐµÐ¶Ð¸Ð¼Ð° HIFU-Ð°Ð±Ð»ÑÑÐ¸Ð¸ ÐºÐ°Ðº Ð½Ð° Ð¼ÑÑÐµÑÐ½Ð¾Ð¹, ÑÐ°Ðº Ð¸ Ð½Ð° Ð¾Ð¿ÑÑÐ¾Ð»ÐµÐ²Ð¾Ð¹ ÑÐºÐ°Ð½Ð¸, Ð³Ð´Ðµ Ð·Ð° ÐºÑÐ¸ÑÐµÑÐ¸Ð¹ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¿ÑÐ¸Ð½Ð¸Ð¼Ð°Ð»Ð¾ÑÑ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ðµ ÐºÐ¾Ð°Ð³ÑÐ»ÑÑÐ¸Ð¾Ð½Ð½Ð¾Ð³Ð¾ Ð½ÐµÐºÑÐ¾Ð·Ð°; ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ðµ Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð¾Ð¿ÑÑÐ¾Ð»ÐµÐ²Ð¾Ð³Ð¾ ÑÑÑÐµÐºÑÐ° HIFU-Ð°Ð±Ð»ÑÑÐ¸Ð¸ Ð¸ ÑÐ¸ÑÐ¾ÑÑÐ°ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ° ÑÐ¸ÐºÐ»Ð¾ÑÐ¾ÑÑÐ°Ð¼Ð¸Ð´Ð° Ñ Ð¼ÑÑÐµÐ¹ Ñ Ð¿ÐµÑÐµÐ²Ð¸ÑÐ¾Ð¹ Ð¾Ð¿ÑÑÐ¾Ð»ÑÑ Ð­ÑÐ»Ð¸ÑÐ°; Ð¾ÑÐµÐ½ÐºÑ Ð¼ÐµÑÐ¾Ð´Ð¾Ð¼ Ð£ÐÐ-ÑÐ»Ð°ÑÑÐ¾Ð³ÑÐ°ÑÐ¸Ð¸ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ð¹ Ð² Ð¼ÑÑÐµÑÐ½Ð¾Ð¹ ÑÐºÐ°Ð½Ð¸ Ð¿Ð¾ÑÐ»Ðµ HIFU- Ð°Ð±Ð»ÑÑÐ¸Ð¸. ÐÑÐ±ÑÐ°Ð½ Ð¾Ð¿ÑÐ¸Ð¼Ð°Ð»ÑÐ½ÑÐ¹ ÑÐµÐ¶Ð¸Ð¼ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¸Ñ HIFU-Ð°Ð±Ð»ÑÑÐ¸Ð¸, Ð¿ÑÐ¸ ÑÑÐ¾Ð¼ ÐµÐ³Ð¾ Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð¾Ð¿ÑÑÐ¾Ð»ÐµÐ²Ð¾Ðµ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ Ð½Ð° Ð¾Ð¿ÑÑÐ¾Ð»Ñ Ð­ÑÐ»Ð¸ÑÐ° Ð±ÑÐ»Ð¾ Ð±Ð¾Ð»ÐµÐµ Ð²ÑÑÐ°Ð¶ÐµÐ½Ð½ÑÐ¼, ÑÐµÐ¼ Ñ ÑÐ¸ÐºÐ»Ð¾ÑÐ¾ÑÑÐ°Ð¼Ð¸Ð´Ð°. Ð ÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¼Ð¾Ð³ÑÑ Ð±ÑÑÑ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ñ Ð² ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½Ð¾Ð¹ Ð¼ÐµÐ´Ð¸ÑÐ¸Ð½Ðµ Ð¿ÑÐ¸ Ð´Ð°Ð»ÑÐ½ÐµÐ¹ÑÐ¸Ñ ÐºÐ»Ð¸Ð½Ð¸ÑÐµÑÐºÐ¸Ñ Ð¸ÑÐ¿ÑÑÐ°Ð½Ð¸ÑÑ HIFU-Ð°Ð±Ð»ÑÑÐ¸Ð¸.
description: The subject of the graduate qualification work is: âThe development of optimal HIFU-ablation regimes on transplantable tumour models in experimental animals.â This work is aimed to develop effective and safe HIFU-ablation regimes on transplantable tumour models in experimental animals using a prototype of the DIATER medical complex. All experiments were performed on the basis of the FSBI âSRC for Oncology named after N.N. Petrovâ, Ministry of Health of Russia, in the laboratory of chemoprevention of cancer and oncopharmacology (head of laboratory â PhD, MD, Vladimir G. Bespalov). Experiments in laboratory animals (in mice and rats) included the following: development of optimal parameters for ablation with High Intensity Focused Ultrasound (HIFU); evaluation by standard histological methods of the effectiveness of the selected HIFU ablation regimes on both muscle and tumour tissue, the development of coagulation necrosis was to be considered as an efficiency criterion; antitumour effect comparison of the HIFU-ablation and of cytostatic preparation â cyclophosphamide in mice with a transplanted Ehrlich tumour; assessment of changes in muscle tissue after HIFU ablation by ultrasound elastography. During the studies, the optimal regime for HIFU-ablation was selected. Its antitumour effect on the Ehrlich tumour was more pronounced than that of cyclophosphamide. The results of this work could be applied in experimental medicine in further clinical trials of HIFU-ablation.