Additional file 1 of Assessment of vulnerability dimensions considering Family History and environmental interplay in Autism Spectrum Disorder
Creators: name: Brito, Anita
name: Franco, Felipe
name: Brentani, Helena
name: Beltrão-Braga, Patrícia Cristina Baleeiro
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Additional file 1: Supplemental Figure 1. Risk Factors Distribution. Distribution of response levels for risk factors variables. The numbers of individuals (n) are displayed in the respective graphs. Supplemental Figure 2. Family History Distribution. Distribution of response levels for family history variables. In all graphs, the number of individuals (n) was 904. Autism Spectrum Disorder (ASD); Attention Deficit Disorder (ADD); Obsessive Compulsive Disorder (OCD). Supplemental Figure 3. Flowchart. Flowchart of the methodological approach. Autism Spectrum Disorder (ASD); Bipolar Disorder (BD); Attention Deficit Disorder (ADD); Intellectual Disability (ID); Obsessive Compulsive Disorder (OCD). Supplemental Figure 4. MCA with risk factors and family history variables (828 individuals and 23 variables). A,  Barplot of contribution of variables to first dimension; B, Barplot of contribution of variables to second dimension; C, MCA biplot visualization of response levels. Autism Spectrum Disorder (ASD); Bipolar Disorder (BD); Attention Deficit Disorder (ADD); Obsessive Compulsive Disorder (OCD); Intellectual Disability (ID). Supplemental Figure 5. MCA biplot of individuals by sex considering EF and FH variables. Males and females are represented by blue and red, respectively. Abbreviations: ASD: Autism Spectrum Disorder; BD, Bipolar Disorder; ADD, Attention Deficit Disorder; OCD, Obsessive Compulsive Disorder; ID, Intellectual Disability. Supplemental Table 1. Number of questions and the content of different questions used to compose different environmental exposure scores and dismissed individuals. Supplemental Table 2. Gestational environmental and FH scores between males and females. Results of the association test between biological sex versus environmental factors and Family History variables. Abbreviations: ASD: Autism Spectrum Disorder; BD, Bipolar Disorder; ADD, Attention Deficit Disorder; OCD, Obsessive Compulsive Disorder; ID, Intellectual Disability. Supplemental Table 3. Eigenvalues, Inertia, Contributions and Cos2of Risk Factors. Risk factors (1782 individuals and 8 variables) - The eigenvalues and proportion of explained inertia of the first ten dimensions, contributions for the variables and squared cosines. Bold characters correspond to positive characteristics. Supplemental Table 4. Eigenvalues, Inertia, Contributions and Cos2 of Family History. Family history for psychiatric disorders - The eigenvalues and proportion of explained inertia of the first ten dimensions, contributions for the variables and squared cosines. Bold characters correspond to positive characteristics. Autism Spectrum Disorder (ASD); Bipolar Disorder (BD); Attention Deficit Disorder (ADD); Obsessive Compulsive Disorder (OCD); Intellectual Disability (ID). Supplemental Table 5. Eigenvalues, Inertia, Contributions and Cos2 of Risk Factors and Family History. Risk factors and family history for psychiatric disorders - The eigenvalues and proportion of explained inertia of the first ten dimensions, contributions for the variables and squared cosines. Bold characters correspond to positive characteristics. Autism Spectrum Disorder (ASD); Bipolar Disorder (BD); Attention Deficit Disorder (ADD); Obsessive Compulsive Disorder (OCD); Intellectual Disability (ID).