cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Unravelling the potentialities of tocilizumab for the development of a potential immunotherapeutic regimen against COVID-19—A narrative review
Creators: name: Dhawan, Manish
name: Dhama, Kuldeep
name: Parmar, Manisha
name: Sharma, Alisha
name: Angural, Steffy
Publisher: name: [Gwalior] : Open Science Publishers LLP
Year: 2021
Subjects: subject: COVID-19
subject: Cytokine storm
subject: hyperinflammation
subject: interleukin-6 (IL-6)
subject: SARSCoV-2
subject: tocilizumab (TCZ)
subject: Dewey Decimal Classification::600 | Technik::610 | Medizin, Gesundheit

description: The severity of COVID-19 (coronavirus disease 2019) disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been associated with hyperinflammation induced by excessive release of a range of cytokines and chemokines. Among a plethora of cytokines, interleukin-6 (IL-6) plays a pivotal role in the immunopathology of SARS-CoV-2 infection as IL-6 has been proposed to initiate hypersecretion of cytokines by activating the Janus kinases-signal transducer and activator of transcription (JAK-STAT) pathway. Hence, targeting IL-6 and its receptor can be an appropriate therapeutic strategy to treat SARS-CoV-2 infection. However, tocilizumab (TCZ) is a well-known monoclonal antibody for its anti-inflammatory activities. TCZ has been designed to bind two different IL-6 receptors, viz., membrane-bound and soluble receptors. As an antagonist of IL-6 receptors, TCZ inhibits the JAK-STAT signaling pathway, which is essential for the transcriptional activation of cytokines-producing genes.Hence, the inhibition of IL-6 receptors can substantially reduce hyperinflammation, a key characteristic of severely infected patients with SARS-CoV-2 infection. TCZ has much promise in terms of treating SARS-CoV-2-related hyperinflammation, acute respiratory distress syndrome, and multiple organ damage. Hence, TCZ has been proposed as a potential therapeutic drug for treating COVID-19 disease. However, several discrepancies still exist, such as a well-defined molecular mechanism, efficacy, and safety parameters. In this context, various databases, including Medline, ResearchGate, PubMed, Science Direct, Scopus, and Google Scholar, were explored employing keywords such as “Cytokine storm”, “COVID-19”, “hyper inflammation”, “IL-6”, “TCZ”, and “SARS-COV-2” up to May 2021. The authors independently collected and evaluated research papers for inclusion in the current review, relying on their relatedness to the main theme of the literature review. So, this narrative review aims to provide updated information about the molecular mechanism, efficacy, and safety of TCZ in the treatment of COVID-19. However,several contradictions and challenges associated with TCZ use in the treatment of severely infected patients with COVID-19 have also been discussed.
Lotta liest Der Lesevorgang im Logogen Modell visualisiert
Creators: name: Heer, Daniela
name: Höppli, Urs
Publisher: name: Zenodo
Year: 2017
Subjects: Logopädie
Lesestörung
Bachelorarbeit

description: Logopädische Fachleute sind gefragt, Schwierigkeiten beim Lesen zu erkennen, einzuordnen und zielgerichtet zu therapieren. Dazu muss der Lesevorgang in seinen Teilprozessen verstanden wer-den. Das Logogen Modell stellt diese als Kästchen und Pfeile dar. Das vereinfacht und bietet die Möglichkeit, Abläufe und Relationen visuell darzustellen. Es ist aber auch abstrakt. Davon lassen sich viele Fachpersonen abschrecken und schöpfen die diagnostischen und therapeutischen Ein-satzmöglichkeiten des Modells nicht aus. Wie kann das Modell den tatsächlichen Vorgängen angenähert werden? Die neuronalen Prozesse während des Lesens sind dynamisch. Das ist auch eine Animation. Die Animation ‘Lotta liest’ begleitet ein Mädchen beim Vorlesen und zeigt auf, was bei den einzelnen Stationen des Logogen Modells passiert. Komm mit und erlebe, wie vielseitig und interessant diese Entdeckungsreise ist!
ПРОГНОЗИРОВАНИЕ РИСКА БАНКРОТСТВА ПРЕДПРИЯТИЯ ПРИ ПОМОЩИ ОТЕЧЕСТВЕННЫХ МОДЕЛЕЙ С ЦЕЛЬЮ СОХРАНЕНИЯ ПЛАТЕЖЕСПОСОБНОСТИ
Creators: name: Ю. Н. Галицкая
name: О. О. Терещенко
Publisher: name: Экономика и бизнес: теория и практика
Year: 2019
Subjects: риск банкротства
модели прогнозирования вероятности банкротства
модель Зайцевой О.П.
модель Савицкой Г.В.
модель Беликова-Давыдовой
несостоятельность
платежеспособность

description: Платежеспособность выступает ключевой характеристикой анализа финансового состояния предприятия. Оценка платежеспособности позволяет спрогнозировать вероятность банкротства хозяйствующего субъекта. Модели прогнозирования вероятности банкротства предприятия отечественных авторов являются адаптированными к особенностям российской экономики, а также имеют отраслевую направленность, что позволяет получить объективную картину прогнозирования банкротства предприятия. В данной статье мы рассмотрели модели российских авторов – Зайцевой О.П., Савицкой Г.В. и модель Беликова-Давыдовой.
Comparative Assessment of Healthcare Service Quality and Customer Satisfaction in Some Selected Public and Private Hospitals in Addis Ababa
Creators: name: Wondwosen, Kassa
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2019

description: Globally many researches have been made in the area of patient satisfaction and service quality, however only few of them are from Africa and particularly Ethiopia. Although there are many efforts made by the government of Ethiopia, the current state of healthcare service quality in health facilities has different types of quality related issues. The purpose of this study was to assess and compare level of healthcare service quality and customers' satisfaction in public and private hospitals in Addis Ababa. The SERVQUAL measurement scale based on Gap Model was used on the study. Black Lion, Saint Paul, Korean and Hayat hospitals were selected for the study with a total of 400 sample size, 100 from each hospital. A descriptive research design was used and the study revealed that perceived healthcare service quality highly explains the satisfaction of customers. All the 22 variables of healthcare service quality and the satisfaction of customers were strongly positively correlated for all the hospitals under the study. Correlation of customer satisfaction with factors that are external to healthcare service quality shows that level of education of respondents has a weak negative correlation with customer satisfaction at Saint Paul hospital. Gender is significantly correlated with customer satisfaction at Hayat hospital. All the hospitals have service quality gap in all the five dimensions of service quality and Black Lion hospital has the highest (-1.84) gap compared to all the other hospitals. The least gap was observed in Korean hospital (-0.49). The level of satisfaction of customers in the hospitals was 20%, 31.63%, 73.25% and 43.56% for Black Lion, Saint Paul, Korean and Hayat hospital respectively. The findings of this study will help different stakeholders working to improve healthcare service quality by guiding where to act.
Insights into biological activity of ureidoamides with primaquine and amino acid moieties
Creators: name: Vlainić, Josipa
name: Kosalec, Ivan
name: Pavić, Kristina
name: Hadjipavlou-Litina, Dimitra
name: Pontiki, Eleni
name: Zorc, Branka
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Primaquine (PQ) ureidoamides 5a–f were screened for antimicrobial, biofilm eradication and antioxidative activities. Susceptibility of the tested microbial species towards tested compounds showed species- and compound-dependent activity. N-(diphenylmethyl)-2-[({4-[(6-methoxyquinolin-8-yl)amino]pentyl}carbamoyl)amino]-4-methylpentanamide (5a) and 2-(4-chlorophenyl)-N-(diphenylmethyl)-2-[({4-[(6-methoxyquinolin-8-yl)amino]pentyl}carbamoyl)amino]acetamide (5d) showed antibacterial activity against S. aureus strains (MIC = 6.5 µg/ml). Further, compounds 5c and 5d had weak antibacterial activity against Escherichia coli and Pseudomonas aeruginosa. None of the tested compounds showed a wide spectrum of antifungal activity. In contrast, most of the compounds exerted strong activity in a biofilm eradication assay against E. coli, P. aeruginosa and Candida albicans, comparable to or even higher than gentamycin, amphotericin B or parent PQ. The most active compounds were 5a and 5b. Tested compounds were inactive against biofilm formation by C. parapsylosis, Enterococcus faecalis, C. tropicalis and C. krusei. Compounds 5b–f significantly inhibited lipid peroxidation (80–99%), whereas compound 5c presented interesting LOX inhibition.
РОЛЬ «ИНКОТЕРМС 2020» В ЭЛИМИНИРОВАНИИ ЛОГИСТИЧЕСКИХ РИСКОВ
Creators: name: Е. Н. Герасикова
Publisher: name: Экономика и бизнес: теория и практика
Year: 2019
Subjects: транспортная логистика
базис поставки
условия поставки
логистический риск
исключение риска
страхование груза.

description: В статье рассмотрены основные риски логистической деятельности и пути их снижения. Отражение получили основные понятия и назначение сборника терминов международной торговой практики «Инкотермс», границы ответственности и риска поставщика и покупателя при поставках продукции и определении влияния выбранных условий поставки на цену перевозимых товарно-материальных ценностей. Изучение изменений, вносимых в его терминологию на современном этапе, позволило определить ряд новых возможностей для снижения логистических рисков участников ВЭД.
title: Διαμόρφωση κόστους και διαχειριστική πολιτική στο δημόσιο και ιδιωτικό τομέα
title: Costing and management policy in the public and private sector
titleType: AlternativeTitle
Creators: name: Τόλια, Μαρία
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2022
Subjects: Κοστολόγηση
Κόστος
Συστήματα υγείας
Διαχείριση κόστους
Τιμολόγηση υπηρεσιών υγείας
Δαπάνες υγείας
Χρηματοδότηση υγείας

description: Το σύστημα υγείας της Ελλάδας ιδρύθηκε με το Νόμο 1397/83 κατά τον οποίο οργανώνονται τα νοσοκομεία, η εποπτεία και η διοίκηση αυτών, ενώ παράλληλα καθορίζονται οι υγειονομικές περιφέρειες της χώρας. Σκοπός ενός ορθά οργανωμένου συστήματος, είναι η όσο το δυνατόν αυξημένη ικανοποίηση των αναγκών του πληθυσμού που εξυπηρετεί, καθώς επίσης και η σωστή διαχείριση του κόστους παραγωγής των ιατρονοσηλευτικών υπηρεσιών ώστε να έχουμε το βέλτιστο οικονομικό αποτέλεσμα. Η χρηματοδότηση της υγείας, είτε μέσω των ασφαλιστικών φορέων είτε μέσω του κρατικού προϋπολογισμού είτε σύμφωνα με το ατομικό εισόδημα του πληθυσμού, κατέχει εξίσου σημαντικό ρόλο στην εξέλιξη του συστήματος υγείας αλλά και στις δαπάνες. Από την άλλη πλευρά, για να μπορέσουν να γίνουν αντιληπτές οι ανάγκες των δημόσιων νοσοκομείων και των ιδιωτικών κλινικών, σε ότι αφορά το κόστος παραγωγής των παρεχόμενων υπηρεσιών τους, οφείλουν να έχουν ένα σωστά οργανωμένο σύστημα διαχειριστικού ελέγχου με το οποίο θα τους δίνεται η δυνατότητα ανάλυσης του κόστους σε κάθε στάδιο της δραστηριότητας και η μελέτη αυτού, ώστε να μπορεί να συμφωνεί με τον προϋπολογισμό. Είναι σημαντικό να αναλύεται το νοσοκομειακό κόστος και για να επιτευχθεί τούτο, πρέπει να γίνεται σαφής κοστολόγηση της ιατρικής πράξης, στοιχείο που αποτελεί και τον βασικότερο παράγοντα του κόστους. Ακόλουθο στάδιο της κοστολόγησης των υπηρεσιών αποτελεί η τιμολόγηση, η οποία είναι με τη σειρά της το καθοριστικό στοιχείο για τον τρόπο με τον οποίο θα δημιουργηθούν κέρδη. Μπορεί το δημόσιο νοσοκομείο να μην έχει ως αυτοσκοπό την κερδοφορία, εν τούτης όμως η τιμολόγηση αποτελεί στάδιο της κοστολόγησης και είναι εξίσου σημαντική ώστε να μπορούν τα χρήματα που θα αποκτηθούν να διατεθούν εκ νέου στο ίδιο το νοσοκομείο, αναπτύσσοντας την λειτουργία του και προσφέροντας καλύτερες υπηρεσίες υγείας στον πληθυσμό. Κλείνοντας, αξίζει να σημειωθεί ότι λόγω της διαφορετικότητας στους στόχους που θέτουν οι ιδιωτικές κλινικές έναντι των δημόσιων νοσοκομείων, παρατηρούνται γενικότερα διαφορές σε όλα τα στάδια δραστηριότητας και λειτουργίας τους. Η κερδοφορία και η εύρυθμη λειτουργία του κάθε ιδρύματος, ώστε να είναι αποτελεσματικό, παραγωγικό και αποδοτικό, αποτελεί απόρροια της διασύνδεσής του με διάφορους παράγοντες όπως είναι το κόστος, η τιμολόγηση και η διαχειριστική πολιτική που ακολουθείται και οφείλει η διοίκηση να ασκεί τα καθήκοντα της έχοντας ως πρότυπο μοντέλο διοίκησης το συμμετοχικό, ώστε να συμβάλουν όλοι οι αρμόδιοι υπεύθυνοι, στη λήψη αποφάσεων, έχοντας πάντα στη σκέψη τους, το τελικό συμφέρον της υγειονομικής μονάδας.
title: ADCO, Cartulaire de Cîteaux pour les possessions de Chaugey et Maison-Dieu (Fin XVe siècle), Cart. 181 (11 H 754), 165 folios, f. 0173
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2017
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire de Cîteaux pour les possessions de Chaugey et Maison-Dieu (Fin XVe siècle), Archives départementales de la Côte-d'Or, Cart. 181 (11 H 754), 165 folios, f. 0173, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour les possessions de Chaugey et Maison-Dieu (Fin XVe siècle), Archives départementales de la Côte-d'Or, Cart. 181 (11 H 754), 165 folios, f. 0173, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Life without Replication in Bacillus subtilis
Creators: name: Munoz Gutierrez, Vivian Vanessa
Publisher: name: Hannover : Institutionelles Repositorium der Leibniz Universität Hannover
Year: 2022
Subjects: subject: Bacillus subtilis
subject: Replication
subject: oriC
subject: DnaA boxes
subject: CRISPR
subject: CRISPRi
subject: Replikation
subject: DnaA boxen
subject: Dewey Decimal Classification::500 | Naturwissenschaften

description: Bacterial replication, as the starting point of the cell cycle, enables the duplication of genomic information and ensures that each daughter cell receives one copy of the parental genetic code. Replication is initiated at the origin of replication (oriC), which contains several sequences called DnaA boxes that serve as binding sites for the master initiator protein DnaA. Absence or failure of DNA replication can lead to bacterial growth arrest or cell death. Our knowledge of the cellular effects of replication arrest comes primarily from studies using thermosensitive mutants, the addition of antibiotics, or the induction via nutrient depletion. Although these studies are useful, they do not provide a global picture of the mere absence of replication initiation in the cell, but are biased by the additional stress conditions. In this study, we aimed to uncover the global effect of life without replication in the model bacterium Bacillus subtilis. For this purpose, we developed two strategies. First, we generated a bacterial strain in which the oriC can be removed by an inducible and customized CRISPR-Cas9 system. After successful deletion of oriC, the cells were no longer able to initiate new rounds of DNA replication and they expressed a fluorescent reporter protein that enabled us to select and characterize the cells by flow cytometry and time-lapse microscopy. Thereby, we were able to produce the deletion of essential sequences for replication. Unfortunately, we found that the recovery and enrichment of non-replicating cells was insufficient and challenging to proceed with a proteomic characterization of these cells. Nevertheless, we characterized a potential tool for the characterization of essential genes and genetic elements in bacteria. In the second part of this work, we blocked replication using a CRISPRi approach by targeting DnaA boxes 6 and 7 with a specific sgRNA and dCas9 expression, which are essential for replication. We characterized the phenotype of these cells and analyzed global changes in the proteome by quantitative Mass Spectrometry. Thereby, we could observe the replication arrested cells were elongated and did not activate neither SOS nor stringent response. Additionally, we confirmed that translation activity of these cells is upregulated. These results expand our understanding of potential direct or indirect connections between replication and translation. At the same time, these experiments provide and a good starting point for better research of non-replicating but translationally active B. subtilis strains. These could also lead to interesting biotechnological applications, such as construction of improved producer strains.
The effect of ETFs on financial markets
Creators: name: Ευγενικού, Μαρία-Ελένη
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2022
Subjects: subject: Comovement
subject: Exchange-traded funds
subject: Liquidity
subject: Price discovery
subject: Volatility

description: Τα ETF (διαπραγματεύσιμα αμοιβαία κεφάλαια) είναι ένα από τα ταχύτερα αυξανόμενα χρηματοπιστωτικά προϊόντα στον κόσμο. Τα συνολικά περιουσιακά στοιχεία που επενδύθηκαν σε ETFs έχουν υπερδιπλασιαστεί μέσα στα τελευταία 15 χρόνια, αγγίζοντας τα 5,1 τρισεκατομμύρια δολάρια στο τέλος του 2021. Τα ETF έχουν ορισμένα οφέλη σε σχέση με τα άλλα επενδυτικά οχήματα. Μερικά από αυτά είναι η άμεση ρευστότητα και το φθηνό κόστος συναλλαγής. Εκτός από τη συνεχιζόμενη άνοδο των ETF, το Flash Crash το 2010 ώθησε τις ρυθμιστικές αρχές να διεξήγαγαν εκτεταμένους ελέγχους σχετικά με τον τρόπο με τον οποίο τα ETF επηρεάζουν τις χρηματοπιστωτικές αγορές. Αυτή η βιβλιογραφική ανασκόπηση παρέχει μια γενική περίληψη των πρόσφατων ακαδημαϊκών μελετών που εξετάζουν τον αντίκτυπο των ETF στη ρευστότητα των υποκείμενων τίτλων, στις τιμές, τη μεταβλητότητα και την εμπορευματοποίηση των τίτλων αυτών και γενικά στον τρόπο που επηρεάζουν την αγορά.
The core in the periphery? The cluster organization as the central node in the Apulian aerospace district
Creators: name: Calignano, Giuseppe
name: Fitjar, Rune Dahl
name: Kogler, Dieter Franz
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Cell Biology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Cluster policy is often ineffective in peripheral regions with weak institutions and significant barriers to knowledge production and exchange. Nonetheless, many peripheral regions have pursued such policies in recent years, an example being technology districts in southern Italy. This paper examines one such district – the aerospace district in Apulia – where policy has focused on indirect support for networking through coordination. This has led to a substantial increase in knowledge exchange within the district, but also to a heavy dependence on the cluster organization itself as the key actor in the knowledge-exchange network.
Additional file 6 of Changes in spike protein antibody titer over 90 days after the second dose of SARS-CoV-2 vaccine in Japanese dialysis patients
Creators: name: Wakai, Haruki
name: Abe, Natsumi
name: Tokuda, Touno
name: Yamanaka, Rika
name: Ebihara, Satoshi
name: Izumaru, Kensuke
name: Ishii, Daisuke
name: Hyodo, Toru
name: Yoshida, Kazunari
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology
subject: Cardiology

description: Additional file 6. Predictive performance of spike protein antibody titers at 30 days for spike protein antibody titers >137 at 90 days.
Regional Bank Establishment and Deposit Mobilization in Ethiopia
Creators: name: Tadios, Alemayehu
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2019

description: The objective of the study was to assess Regional Bank Establishment and Deposit Mobilization in Ethiopia. More specifically, to find out the role of government policy on deposit mobilization in Ethiopian banking industry, to identify the effects of political instability, and ethnic based bank establishment on deposit mobilization in Ethiopian banking industry. Descriptive research design was employed. The sample size of this study was 370. This study used a statistical analysis program called Statistical Package for the Social Sciences (SPSS – Version 23). This study found that the government policy and financial system of Ethiopia is not facilitating deposit mobilization in the private bank of the country. Establishing, and naming of private banks in Ethiopia with the name of a specific ethnic group, the result showed that these kinds of trend have adverse consequences. This study recommended that when private banks are established, they should consider non ethnic based establishment to mobilize deposits as much as possible.
New horizons in microparticle forensics: Actinide imaging and detection of 238 Pu and 242m Am in hot particles
Creators: name: Bosco, Hauke
name: Hamann, Linda
name: Kneip, Nina
name: Raiwa, Manuel
name: Weiss, Martin
name: Wendt, Klaus
name: Walther, Clemens
Publisher: name: Washington, DC [u.a.] : Assoc.
Year: 2021
Subjects: subject: Forensic science
subject: Health risks
subject: Isotopes
subject: Cosmochemistry
subject: Environmental science
subject: Hot particles
subject: Human environment
subject: Life-sciences
subject: Micro particles
subject: Pollutant particles
subject: Potential risks
subject: Risk to human health
subject: Secondary ion-mass spectrometry
subject: Secondary ion mass spectrometry
subject: Dewey Decimal Classification::500 | Naturwissenschaften

description: Micrometer-sized pollutant particles are of highest concern in environmental and life sciences, cosmochemistry, and forensics. From their composition, detailed information on origin and potential risks to human health or environment is obtained. We combine secondary ion mass spectrometry with resonant laser ionization to selectively examine elemental and isotopic composition of individual particles at submicrometer spatial resolution. Avoiding any chemical sample preparation, isobaric interferences are suppressed by five orders of magnitude. In contrast to most mass spectrometric techniques, only negligible mass is consumed, leaving the particle intact for further studies. Identification of actinide elements and their isotopes on a Chernobyl hot particle, including 242mAm at ultratrace levels, proved the performance. Beyond that, the technique is applicable to almost all elements and opens up previously unexplored scientific applications.
title: Σχεδιασμός 3D μοντέλων (εκθεμάτων) και Εικονικής ξενάγησης (Virtual Tour) ενός πολεμικού μουσείου
title: Design of 3D models (exhibits) and Virtual Tour of a war museum
titleType: AlternativeTitle
Creators: name: Προκοπίου, Ραφαήλ
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2022
Subjects: Επαυξημένη πραγματικότητα
Augmented reality
3D Modeling
Εικονική πραγματικότητα
Virtual reality

description: Ένα πολεμικό μουσείο στο οποίο ο θεατής μπορεί να περιηγηθεί χρησιμοποιώντας την Εικονική ξενάγηση και να αξιοποιήσει κάποια εργαλεία όπως την Εικονική πραγματικότητα, την Επαυξημένη πραγματικότητα και άλλα, για σκοπούς διασκέδασης αλλά και εκπαίδευσης.
The effect of dietary energy:protein ratio, protein quality and food allocation on the efficiency of utilisation of protein by broiler chickens
Creators: name: R. M. Gous
name: A. S. Faulkner
name: H. K. Swatson
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Neuroscience
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 111714 Mental Health
subject: FOS: Health sciences

description: 1. Various theories have been proposed to explain the reduced performance of broilers when given feeds excessively high in protein, but a satisfactory solution to this problem had, up to now, not been found. Three experiments were conducted to test the hypothesis that the efficiency of utilisation of protein (ep) is a linear–plateau function of the ratio between the feed apparent metabolisable energy and digestible crude protein contents (AMEn:DCP) and that dietary protein quality, feed allocation and sex do not influence this relationship. 2. A ‘linear–plateau’ model successfully described the efficiency of protein utilisation (ep) as a function of AMEn:DCP in all three experiments. In Experiment 1, with both sexes being both ad libitum and control fed, the breakpoint was at 58.6 MJ AMEn/kg DCP. In Experiment 2, both sexes were fed balanced and unbalanced protein series, and at different rates, the slopes of the ascending part of the linear–plateau relationships for the different treatments were the same for all treatments (0.0204), and the inflection point was at 71 MJ AMEn/kg DCP. Using similar treatments in Experiment 3, the breakpoint for the balanced protein was 72 MJ/kg and for the unbalanced, 64, with a combined slope of 68 MJ AMEn/kg DCP. 3. The three experiments provide adequate evidence that ep is a linear–plateau function of the dietary AMEn:DCP ratio with a breakpoint of around 66.2 ± 1.98 MJ AMEn/kg DCP. Below this critical ratio, food intake declines as does protein and lipid retention. 4. That broilers, like pigs, exhibit an energy-dependent phase when high-protein feeds are offered is of practical importance when formulating pre-starter feeds for broilers and starter feeds for turkey poults as the ep of such feeds may well fall below the maximum due to the lack of dietary energy required to process the high dietary protein contained in such feeds resulting in poorer performance than expected.
E-(m)PACT
Creators: name: Novo, Cristina
name: Torres, Ana Luísa
name: Dias, José Maurício
name: Amendoeira, José
name: Pinto, Maria Rosário
Publisher: name: Revista UIIPS
Year: 2020

description: E-(m)PACT is an Erasmus + KA202 (Cooperation for Innovation and the Exchange of Good Practices - Strategic Partnerships for vocational education and training) project. The project aims at creating a model for the efficient combining of simulation and media in the practical training of the students in healthcare education, offering in the same time guidance on how to implement it in any college. The partnership is formed of 6 partners, Romania, Denmark, Portugal, Turkey, Netherlands and Spain covering different cultures, training healthcare at various levels but having expertise in both media and healthcare training. The main objectives of the project are: to improve the quality of education in the field of healthcare (HC), to make HC education more accessible and attractive for the students and to foster the exchange of good practices among the partners and to combine their expertise in developing and delivering the intellectual results of the project. The main tangible results of the project will be: • A starter- package containing: A Handbook on how to implement the simulation in any HC college and a Guide on how media use can enhance and document simulation • A collection of scenarios for basic healthcare practice and a guide on how to produce good scenarios, accompanied by a collection of small videos illustrating the scenarios for basic healthcare practice • A collection of model tutorials for the theoretical and practical training of students used in the regular educational process of the partner institutions. The project will comprise joint short staff training events (3x 5 days) for training them into using simulation and media in training, for developing scenarios and for putting together the above-mentioned outputs and students short term motilities’ (2 x 5 days) for developing and testing scenarios. IT Responsible staff will also be a part of the project from the beginning, ensuring technical support, offering ideas and fine tuning the final versions of the outputs. The project is expected to have a big impact at EU level, offering a model for combining simulation and media in healthcare, as well as guidance into working with both.
description: Revista UIIPS, vol. 7 n.º 2 (2019): Congresso Internacional da Unidade de Investigação do IPSantarém - Parte II
Supplementary information from How calorie-rich food could help marine calcifiers in a CO2-rich future
Creators: name: Leung, Jonathan Y. S.
name: Doubleday, Zoë A.
name: Nagelkerken, Ivan
name: Chen, Yujie
name: Xie, Zonghan
name: D. Connell, Sean
Publisher: name: The Royal Society
Year: 2019

description: Seawater chemistry, nutritional quality of algae, shell properties of gastropods and statistical analysis
Verification of the code to calculate duct flow affected by external magnetic field
Creators: name: Smolyanov, I.A.
name: Shmakov, E.I.
name: Baake, E.
name: Guglielmi, M.
Publisher: name: Perm : [Verlag nicht ermittelbar]
Year: 2021
Subjects: subject: Elmer
subject: EOF-library
subject: Magnetohydrodynamics
subject: OpenFOAM
subject: Software verification
subject: Dewey Decimal Classification::600 | Technik::620 | Ingenieurwissenschaften und Maschinenbau

description: In this paper, the authors present the results of software verification for solving magnetohydrodynamic problem in duct exposed to constant magnetic fields. The proposed approach uses the following open source software: OpenFOAM for solving problems of continuum mechanics using the finite volume method, Elmer for solving magnetic field distribution based on the finite element method, and EOF-library for data exchange between these two programs. The verification results were demonstrated by fluid flow in a square duct exposed to constant uniform spanwise magnetic field. The research was carried out with a laminar fluid flow, which makes it similar to the Hartmann's problem. The existing experience of calculating such problems, their verification and application were discussed. The paper provides a brief mathematical description of the proposed solution and basic procedures for implementing the code proposed by the authors. At the first stage of verification, the comparison of fluid velocity distribution results at Hartmann’s numbers equal to 1, 10, 20 and 50 was demonstrated. These results were obtained by means of proposed software, an analytical solution, and a test problem provided by OpenFOAM developers for two-dimensional case. At the second stage of software verification, sufficient convergence of the results was shown for fluid velocity distribution in the three-dimensional case of the Hartmann’s problem compared with the OpenFOAM test problem data and the results obtained by Comsol Multiphisics and ANSYS. As a result, distributions of the fluid flow velocity between Hartmann’s walls were obtained for various study cases: a two-dimensional problem, a three-dimensional problem with electrically insulated walls, and a three-dimensional problem with walls having infinite electrical conductivity. The last stage of the study corresponds to assessing of software performance in comparison with the built-in OpenFOAM solver and commercial software Comsol Multiphysics and ANSYS. It was found that the proposed approach takes more time to calculate these problems than the built-in OpenFOAM solver, but less than Comsol. However, the problem formulation in EOF-library allows solving problems with complex geometry, which is not available in the built-in OpenFOAM solver. In conclusion, analysis of computation performance with parallelization was carried out. It showed significant reducing of computation time with the help of EOF-library in comparison with the commercial software Comsol and ANSYS.
Μοντέλο πρόβλεψης μετοχικών τιμών βασισμένο σε γενετικούς αλγορίθμους και νευρωνικά δίκτυα
Creators: name: Κεφαλά, Μαργαρίτα
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2022
Subjects: subject: Νευρωνικά δίκτυα
subject: Γενετικοί αλγόριθμοι
subject: Πρόβλεψη τιμών χρονοσειράς
subject: Πρόβλεψη χρηματιστηριακών τιμών
subject: Ενισχυτική μηχανική μάθηση
subject: Μηχανική Μάθηση
subject: Πρόβλεψη μετοχικών τιμών

description: Στην παγκόσμια οικονομία όλα επηρεάζονται αλυσιδωτά, για αυτό ακριβώς το λόγο η πρόβλεψη των τιμών του χρηματιστηρίου είναι αναγκαία όχι μόνο για επενδυτές αλλά και για άτομα που δεν ενασχολούνται με αυτό. Για παράδειγμα έστω ότι η μετοχική τιμή μιας εγχώριας τράπεζας ξεκινά και πέφτει ραγδαία, αυτομάτως σηματοδοτεί τη δυσχερή θέση της εν λόγω με αποτέλεσμα οι καταθέτες να ξεκινούν τις μαζικές και ογκώδεις αναλήψεις. Οι δανειολήπτες αυτής θα έρθουν αντιμέτωποι με μεγαλύτερα επιτόκια δανεισμού, θα «αγοράζουν χρήμα ακριβότερα». Έτσι ένας εκτός χρηματοοικονομικού κύκλου επιχειρηματίας που έχει άμεση ανάγκη από ρευστό δεν θα μπορέσει να δανειστεί από την εν λόγω τράπεζα με αποτέλεσμα ακόμη και να έρθει στη δυσμενή θέση να κλείσει την επιχείρησή του. Η αγορά των μετοχών θεωρείται ένα χαοτικό, περίπλοκο, εύθραυστο και δυναμικό περιβάλλον. Ωστόσο η πρόβλεψη των μετοχικών τιμών αποτελεί μια από τις πιο πολυσυζητημένες προκλήσεις. Η εξέλιξη της Μηχανικής Μάθησης έχει παρουσιάσει αξιοσημείωτα αποτελέσματα στην αναγνώριση ήχου, ταξινόμηση εικόνας. Εύλογα λοιπόν θεωρείται ότι οι μέθοδοι που εφαρμόζονται στην επεξεργασία ψηφιακών σημάτων μπορούν και να εφαρμοστούν σε χρηματιστηριακές τιμές καθώς και τα δυο επίπεδα αποτελούν δεδομένα χρονοσειρών. Στόχος της παρούσας διπλωματικής εργασίας είναι η πρόβλεψη μετοχικών τιμών με μοντέλο το οποίο εκπαιδεύεται σύμφωνα με την Ενισχυτική Μηχανική Μάθηση κάνοντας χρήση των Γενετικών Αλγορίθμων και των Τεχνητών Νευρωνικών Δικτύων. Ως δεδομένα για έλεγχο και επαλήθευση του μοντέλου μας χρησιμοποιήθηκαν ελληνικών τραπεζών μετοχικές τιμές, όπως έχουν οριστεί στο Χρηματιστήριο Αθηνών.
Additional file 7 of Changes in spike protein antibody titer over 90 days after the second dose of SARS-CoV-2 vaccine in Japanese dialysis patients
Creators: name: Wakai, Haruki
name: Abe, Natsumi
name: Tokuda, Touno
name: Yamanaka, Rika
name: Ebihara, Satoshi
name: Izumaru, Kensuke
name: Ishii, Daisuke
name: Hyodo, Toru
name: Yoshida, Kazunari
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology
subject: Cardiology

description: Additional file 7. a. Correlation between anti-S IgM antibody titers and anti-S IgG antibody titers. b. Correlation between anti-S IgM antibody titers and anti-S IgG antibody titers (correlation between the maximums of both titers).
Paratuposa placentis flight data
Creators: name: Kolomenskiy, Dmitry
name: Farisenkov, Sergey
name: Petrov, Pyotr
name: Lapina, Nadezhda
name: Engels, Thomas
name: Lehmann, Fritz-Olaf
name: Onishi, Ryo
name: Liu, Hao
name: Polilov, Alexey
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Physical Sciences and Mathematics
subject: Life Sciences
subject: Physics
subject: Fluid Dynamics
subject: Entomology
subject: Animal flight
subject: Bristled wing
subject: CFD
subject: Micro-insect

description: Supporting data for the article "Novel flight style and light wings boost flight performance of tiny beetles" by S. E. Farisenkov, D. Kolomenskiy, P. N. Petrov, T. Engels, N. A. Lapina, F.-O. Lehmann, R. Onishi, H. Liu & A. A. Polilov. https://doi.org/10.1038/s41586-021-04303-7 (doi link to be activated)
The Effect of Performance Management System on Organizational Effectiveness: In the Case of Ethiopian Roads Authority
Creators: name: Araya, Abraham
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2018

description: The general objective of this study was to investigate the effect of Performance Management System (PMS) on Organizational Effectiveness (OE) in Ethiopian Roads Authority (ERA). Mixed of qualitative and quantitative research methodology has been used by the research. Among the total population of 2897 employees in ERA, 200 respondents were selected through stratified sampling design and 13 interviewees were also selected through purposive sampling design. Structured type of questionnaire has been employed, while semi-structured type of interview has been also used to collect primarily data. The study used both primary and secondary sources of data to gather the required information. Thematic, content and comparative data analysis techniques have been applied to analyze the data gathered through interviews. 'Karl Pearson's Correlation Coefficients' has been put in use to do the correlation analysis, while 'Simple Linear Regression' has been also employed to provide regression analysis. The research findings have shown that there is a positively significant relationship between each dimension of PMS (performance pre-requisites, performance planning, performance execution, performance evaluation, performance review, and performance renewal and re-contraction) and OE. And the study also proved there is a positively significant association between the overall PMS and OE. HR managers can use the results of this study for identification and bridging of the gaps related to the PMS, and to get the direction and guidelines to improve the level of PMS and OE in large.
title: Η διαχείριση του ανθρώπινου δυναμικού στο χώρο της υγείας. Πρακτικές ανάπτυξης και εκπαίδευσης. Μελέτη περίπτωσης σε ιδιωτικό νοσοκομείο
title: Human resource management in the healthcare sector. Development and training practices case study in a private hospital
titleType: AlternativeTitle
Creators: name: Ελευθερίου, Χρυσαφούλα
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2022
Subjects: subject: Διοίκηση ανθρώπινου δυναμικού
subject: Διαχείριση
subject: Ανάπτυξη
subject: Εκπαίδευση

description: Αρχικά πρέπει να αναφερθεί πως στη σημερινή εποχή ο χώρος της υγείας διέρχεται από μια κατάσταση έντονων αναταράξεων λόγω της οικονομικής κρίσης που πλήττει την χώρα μας περίπου μία δεκαετία τώρα. Για τον λόγο αυτό ο ρόλος των τμημάτων Διοίκησης Ανθρωπίνου δυναμικού (HR) αποτελεί το ύψιστο σημείο που απαραίτητα χρειάζεται να διαθέτει ο κάθε οργανισμός, καθώς θεωρείται πηγή ανταγωνιστικού πλεονεκτήματος. Αξιοσημείωτο είναι επίσης να αναφερθεί ότι η Διοίκηση Ανθρωπίνου Δυναμικού αντιμετωπίζει τον άνθρωπο σαν περιουσιακό στοιχείο του οργανισμού, κάτι το οποίο είναι υψίστης σημασίας και για τον ίδιο τον άνθρωπο. Η παρούσα εργασία έχει ως σκοπό να διερευνήσει τις πρακτικές ανάπτυξης, εκπαίδευσης και διαχείρισης ανθρωπίνου δυναμικού και συγκεκριμένα στο χώρο της υγείας. Για την επίτευξη του στόχου αυτού χρησιμοποιείται ερωτηματολόγιο το οποίο διαθέτει εύστοχες ερωτήσεις σχετικά με τη Διοίκηση Ανθρωπίνου Δυναμικού. Στην έρευνα συμμετείχαν υπεύθυνοι εκπαίδευσης ανθρωπίνου δυναμικού ιδιωτικού νοσοκομείου καθώς επίσης και εργαζόμενοι νοσοκομείου και πιο συγκεκριμένα, γυναικολόγοι, νοσηλευτές, μαίες και διοικητικό προσωπικό. Τα συγκεντρωθέντα στοιχεία επεξεργάσθηκαν με την βοήθεια του Microsoft Office Excel 2010 και του στατιστικού προγράμματος Spss. Στη συνέχεια μέσω του Spss αναλύθηκαν τα αποτελέσματα και εξήχθησαν τα συμπεράσματα της έρευνας. Βασικό συμπέρασμα της έρευνας που διενεργήθηκε, αποτελεί το γεγονός πως η διοίκηση ανθρωπίνου δυναμικού αποτελεί ένα από τα βασικότερα τμήματα ενός οργανισμού - επιχείρησης. Ως στόχο μεταξύ άλλων έχει τις απαραίτητες ενέργειες για την εργασιακή και προσωπική ικανοποίηση των εργαζομένων όπως και την ανάπτυξη των καλών σχέσεων μεταξύ τους. Συνοπτικά, με βάση τα αποτελέσματα της Έρευνας είναι σαφές ότι στο νοσοκομείο Μητέρα λειτουργεί ξεχωριστό και ανεξάρτητο τμήμα Διοίκησης Ανθρωπίνων πόρων.
Three Reasons Why Aspartic Acid and Glutamic Acid Sequences Have a Surprisingly Different Influence on Mineralization
Creators: name: Lemke, Tobias
name: Edte, Moritz
name: Gebauer, Denis
name: Peter, Christine
Publisher: name: Washington, DC : Americal Chemical Society
Year: 2021
Subjects: subject: Aspartic Acid
subject: Calcium
subject: Glutamic Acid
subject: Ions
subject: Peptides
subject: Amino acids
subject: Bioinformatics
subject: FOS: Computer and information sciences
subject: Carboxylation
subject: Chlorine compounds
subject: Mineralogy
subject: Molecular dynamics
subject: aspartic acid
subject: calcium
subject: glutamic acid
subject: ion
subject: peptide
subject: Aspartic acids
subject: Carboxylate groups
subject: Chemical similarity
subject: Ion interactions
subject: Mineralization process
subject: Molecular dynamics simulations
subject: Precise control
subject: Simulation data
subject: Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik

description: Understanding the role of polymers rich in aspartic acid (Asp) and glutamic acid (Glu) is the key to gaining precise control over mineralization processes. Despite their chemical similarity, experiments revealed a surprisingly different influence of Asp and Glu sequences. We conducted molecular dynamics simulations of Asp and Glu peptides in the presence of calcium and chloride ions to elucidate the underlying phenomena. In line with experimental differences, in our simulations, we indeed find strong differences in the way the peptides interact with ions in solution. The investigated Asp pentapeptide tends to pull a lot of ions into its vicinity, and many structures with clusters of calcium and chloride ions on the surface of the peptide can be observed. Under the same conditions, comparatively fewer ions can be found in proximity of the investigated Glu pentapeptide, and the structures are characterized by single calcium ions bound to multiple carboxylate groups. Based on our simulation data, we identified three reasons contributing to these differences, leading to a new level of understanding additive-ion interactions.
The effect of Outsourcing on Organizational Performance: the case of International Livestock Research Institute /ILRI-Addis Ababa
Creators: name: Thomas, Getahun
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2019

description: In recent years, global economic challenge with resource limitations is increasingly growing pressure on competitive advantage of firm. Organizations need to find strong ways to deal with this changing environment. The success of organization depends greatly on many factors such as productivity, cost efficiency and successful strategic human resource management. With dynamic environment, outsourcing turns to be an important tool of strategic management of firm. Therefore, this study is aimed to explain the impact of outsourcing dimensions (cost driven outsourcing, innovation driven outsourcing, focus on core competencies driven outsourcing and quality driven outsourcing) on organizational performance, by focusing on International Livestock Research Institute/ILRI-Addis Ababa. A conceptual framework was used as a guideline to test the relationships between outsourcing dimensions and organizational performance. A quantitative approach is chosen in this research. In order to collect primary data, a questionnaire is designed and was given to the staff of ILRI. The target populations of the study were all ILRI permanent employees in Addis Ababa. Out of 200 distributed only 186 complete questionnaires were used for analysis. The SPSS version 20.00 for windows is used to process the data which is collected through questionnaire. Regression analysis was used to test the significance contribution of each independent variable to the dependent variable of organizational performance. The findings show that cost driven outsourcing, focus on core competencies driven outsourcing and quality driven outsourcing dimensions have significant and positive impact on organizational performance. However, the innovation driven outsourcing is positively but not significantly effect to organizational performance in ILRI-Addis Ababa. Therefore, ILRI should outsource with a clear picture in mind as to why it wants to outsource. When ILRI outsources it should have measurable indicators in form of Key Performance Indicators for the service provider.
title: Εφαρμογή φακών επαφής μετά από cross-linking
title: Contact lenses fitting post cross-linking
titleType: AlternativeTitle
Creators: name: Χριστόπουλος, Νικόλαος
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2022
Subjects: Φακοί επαφής
Cross-linking
Κερατόκωνος
Κερατοειδής
Σκληρικοί φακοί

description: Διπλωματική Εργασία
description: Στόχος της παρούσας διπλωματικής εργασίας, είναι η συγκέντρωση των διαθέσιμων γνώσεων για την εφαρμογή φακών επαφής μετά από το cross-linking σε ένα εννιαίο έργο. Ουσιαστικά, αναλύεται ο κερατόκωνος ως παθολογική οντότητα, η σταθεροποίησή του με το cross-linking καθώς και όλοι οι διαθέσιμοι φακοί επαφής που μπορούν να εφαρμοστούν εδώ. Βέβαια, βαρύτητα δίνεται στην κερατοειδική επούλωση που απαιτείται έπειτα από cross-linking καθώς και στις τοπογραφικές, παχυμετρικές, διαθλαστικές και αισθητηριακές κερατοειδικές μεταβολές, που επηρεάζουν βαθύτατα την εφαρμογή φακών επαφής μετεπεμβατικά. Επιπρόσθετα, μέσα από σαφή βιβλιογραφική τεκμηρίωση, περιγράφεται η ασφάλεια της χρήσης φακών επαφής μετεπεμβατικά αλλά και η χρονική περίοδος που απαιτείται να μεσολαβήσει μεταξύ της κερατοειδικής διασύνδεσης και της εφαρμογής φακών επαφής. Τέλος περιγράφονται τα «σημεία κλειδιά» για την εφαρμογή κάθε τύπου φακών επαφής μετεπεμβατικά.
ЗООПЛАНКТОН ПЕТРОЗАВОДСКОЙ ГУБЫ ОНЕЖСКОГО ОЗЕРА В ПОДЛЕДНЫЙ ПЕРИОД // УЧЕНЫЕ ЗАПИСКИ ПЕТРОЗАВОДСКОГО ГОСУДАРСТВЕННОГО УНИВЕРСИТЕТА. № 6 (167). 2017. С.90-95.
Creators: name: Юлия Фомина
name: СЯРКИ МАРИЯ
Publisher: name: figshare
Year: 2018
Subjects: subject: 60204 Freshwater Ecology
subject: FOS: Biological sciences

description: Подробные исследования подледного состояния зоопланктона Петрозаводской губы Онежского озера проходили в рамках проекта «Lake Ladoga: Life under ice» в марте 2015 и 2016 годов. Зимний зоопланктон характеризовался бедностью видового состава (24 вида) и количества (0,5 тыс. экз./м3 и 0,016 г/м3). Основу его по численности (91 %) и по биомассе (98 %) составляли взрослые веслоногие рачки и их науплиальные стадии. Биомасса зоопланктона в столбе воды увеличивалась с глубиной и уменьшалась в прибрежной зоне. Изучено вертикальное распределение зоопланктона и отдельных его видов. Количество зоопланктона достоверно различалось по годам. В 2015 году наблюдалась фаза конвективного перемешивания, а в 2016 году - нет, что связано со смещением фазы термического режима. Состав, структура и количество зоопланктона не изменились с 60-х годов прошлого века, что указывает на устойчивость его функционирования.