cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Deep Convolutional Neural Networks Based on Semi-Discrete Frames
Creators: name: Wiatowski, Thomas
name: Bölcskei, Helmut
Publisher: name: arXiv
Year: 2015
Subjects: subject: Machine Learning (cs.LG)
subject: Information Theory (cs.IT)
subject: Functional Analysis (math.FA)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: Deep convolutional neural networks have led to breakthrough results in practical feature extraction applications. The mathematical analysis of these networks was pioneered by Mallat, 2012. Specifically, Mallat considered so-called scattering networks based on identical semi-discrete wavelet frames in each network layer, and proved translation-invariance as well as deformation stability of the resulting feature extractor. The purpose of this paper is to develop Mallat's theory further by allowing for different and, most importantly, general semi-discrete frames (such as, e.g., Gabor frames, wavelets, curvelets, shearlets, ridgelets) in distinct network layers. This allows to extract wider classes of features than point singularities resolved by the wavelet transform. Our generalized feature extractor is proven to be translation-invariant, and we develop deformation stability results for a larger class of deformations than those considered by Mallat. For Mallat's wavelet-based feature extractor, we get rid of a number of technical conditions. The mathematical engine behind our results is continuous frame theory, which allows us to completely detach the invariance and deformation stability proofs from the particular algebraic structure of the underlying frames.
description: Proc. of IEEE International Symposium on Information Theory (ISIT), Hong Kong, China, June 2015, to appear
(400874) Edith [Bellenden] Wallace
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Supplemental material from Sleep restriction caused impaired emotional regulation without detectable brain activation changes—a functional magnetic resonance imaging study
Creators: name: Tamm, Sandra
name: Nilsonne, Gustav
name: Schwarz, Johanna
name: Armita Golkar
name: Kecklund, Göran
name: Petrovic, Predrag
name: Fischer, Håkan
name: Åkerstedt, Torbjörn
name: Lekander, Mats
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Neuroscience
subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology
subject: 60801 Animal Behaviour
subject: FOS: Biological sciences

description: Figures and tables reporting results for the older group
(400873) Maria Chalmers
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Architecture and construction: topical themes in the teaching of Auguste Choisy
Creators: name: Landsberger, Martina
Publisher: name: TECHNE - Journal of Technology for Architecture and Environment
Year: 2017

description: The relationship between theory and practice, ideas and realisation, has always been a key feature in the evolution of classical architecture. Histoire de l’Architecture by Auguste Choisy, a French engineer working in the second half of the 19th century, is built precisely on a desire to illustrate this specific project feature. The purpose of this article is to throw light on the topical nature of this current of thought in reference to the work of one modern (Auguste Perret) and one contemporary (Pritzker Prize winner Paulo Mendes da Rocha) architect who have interpreted design as the outcome of thought (theory) and practice (construction).
description: TECHNE - Journal of Technology for Architecture and Environment, TECHNE 13 (2017): Theories Practice Design
Supplemental Methods from Conspecific sperm precedence is reinforced, but postcopulatory sexual selection weakened, in sympatric populations of Drosophila.
Creators: name: Castillo, Dean M.
name: Moyle, Leonie C.
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology

description: Sexual selection can accelerate speciation by driving the evolution of reproductive isolation, but forces driving speciation could also reciprocally feedback on sexual selection. This might be particularly important in the context of ‘reinforcement’, where selection acts directly to increase prezygotic barriers to reduce the cost of heterospecific matings. Using assays of sperm competition within and between two sister species, we show a signature of reinforcement where these species interact: populations of Drosophila pseudoobscura that co-occur with sister species D. persimilis have an elevated ability to outcompete heterospecific sperm, consistent with selection for increased postcopulatory isolation. We also find these D. pseudoobscura populations have decreased sperm competitive ability against conspecifics, reducing the opportunity for sexual selection within these populations. Our findings demonstrate that direct selection to increase reproductive isolation against other species can compromise the efficacy of sexual selection within species, a collateral effect of reproductive traits responding to heterospecific interactions.
A first in man phase I trial of the oral immunomodulator, indoximod, combined with docetaxel in patients with metastatic solid tumors
Creators: name: Sullivan, Daniel M.
name: Ismail-Khan, Roohi
name: Soliman, Hatem H.
name: Antonia, Scott
name: Link, Charles
name: Donald Harvey, R.
name: Han, Hyo
name: Neuger, Tony
name: Claire Dees, E.
name: Minton, Susan
name: Vahanian, Nicholas N.
name: Jackson, Erica
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: BackgroundIndoleamine 2,3-dioxygenase (IDO) is an enzyme that tumors use to create a state of immunosuppression. Indoximod is an IDO pathway inhibitor. Preclinical studies demonstrated that indoximod combined with chemotherapy was synergistic in a mouse model of breast cancer. A phase I 3+3 trial was designed to study the combination of docetaxel and indoximod.MethodsDocetaxel was administered at 60 mg/m2 intravenously every 3 weeks dose levels 1-4 and 75 mg/m2 for dose level 5. Indoximod was given at 300, 600, 1000, 2000, and 1200 mg PO twice daily continuously for levels 1-5, respectively. Serum drug levels were measured.ResultsTwenty-seven patients were treated, with 22 evaluable for response. DLTs included grade 3 dehydration (level 1), hypotension(level 4), mucositis (level 4) and grade 5 enterocolitis (level 2). Dose level 5 is the recommended phase II dose. The most frequent adverse events were fatigue (58.6%), anemia (51.7%), hyperglycemia (48.3%), infection (44.8%), and nausea (41.4%). There were 4 partial responses (2 breast, 1 NSCLC, 1 thymic tumor). No drug-drug interactions were noted.ConclusionsDocetaxel plus indoximod was well tolerated with no increase in expected toxicities or pharmacokinetic interactions. It was active in a pretreated population of patients with metastatic solid tumors.
Mer590, a novel monoclonal antibody targeting MER receptor tyrosine kinase, decreases colony formation and increases chemosensitivity in non-small cell lung cancer
Creators: name: Cummings, Christopher T.
name: Sather, Susan
name: DeRyckere, Deborah
name: Linger, Rachel M.A.
name: Cohen, Rebecca A.
name: Shelton Earp, H.
name: Graham, Douglas K.
name: Kirkpatrick, Gregory D.
name: Davies, Kurtis D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The successes of targeted therapeutics against EGFR and ALK in non-small cell lung cancer (NSCLC) have demonstrated the substantial survival gains made possible by precision therapy. However, the majority of patients do not have tumors with genetic alterations responsive to these therapies, and therefore identification of new targets is needed. Our laboratory previously identified MER receptor tyrosine kinase as one such potential target. We now report our findings targeting MER with a clinically translatable agent – Mer590, a monoclonal antibody specific for MER. Mer590 rapidly and robustly reduced surface and total MER levels in multiple cell lines. Treatment reduced surface MER levels by 87%, and this effect was maximal within four hours. Total MER levels were also dramatically reduced, and this persisted for at least seven days. Mechanistically, MER down-regulation was mediated by receptor internalization and degradation, leading to inhibition of downstream signaling through STAT6, AKT, and ERK1/2. Functionally, this resulted in increased apoptosis, increased chemosensitivity to carboplatin, and decreased colony formation. In addition to carboplatin, Mer590 interacted cooperatively with shRNA-mediated MER inhibition to augment apoptosis. These data demonstrate that MER inhibition can be achieved with a monoclonal antibody in NSCLC. Optimization toward a clinically available anti-MER antibody is warranted.
Executive design and hermeneutics of téchne
Creators: name: Nastri, Massimiliano
Publisher: name: TECHNE - Journal of Technology for Architecture and Environment
Year: 2017

description: The study concerns the contribution of technique towards the definition of the “executive” design, according to the connections with the conceptual apparatus aimed at defining the procedures and tools, both theoretical and practical, for the necessary knowledge and action within the production and construction environment. The analysis describes the work of “mediation” of technique towards the exploration of reality, according to the processes of “transcendence” and “artificial reproduction” supporting the modelling and simulation practices of the executive experience. Furthermore, the analysis focuses on the instrumentality introduced in the project by technique, with the aid of “executive models” pointing towards the anticipation and the “rational estimate” (by means of “pro-duction” and “operational representation” criteria).
description: TECHNE - Journal of Technology for Architecture and Environment, TECHNE 13 (2017): Theories Practice Design
Fachkräftesituation in Einrichtungen der Offenen Kinder- und Jugendarbeit : Länderauswertung Niedersachsen
Creators: name: Voigts, Gunda
name: Przybylski, Katharina
Publisher: name: HAW Hamburg
Year: 2025
Subjects: subject: 360: Soziale Probleme, Sozialarbeit

description: Auswertung einer Befragung von Einrichtungen der Offenen Kinder- und Jugendarbeit zur Fachkräftesituation - Länderauswertung Niedersachsen.
Supplemental Methods from Conspecific sperm precedence is reinforced, but postcopulatory sexual selection weakened, in sympatric populations of Drosophila
Creators: name: Castillo, Dean M.
name: Moyle, Leonie C.
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology

description: Sexual selection can accelerate speciation by driving the evolution of reproductive isolation, but forces driving speciation could also reciprocally feedback on sexual selection. This might be particularly important in the context of ‘reinforcement’, where selection acts directly to increase prezygotic barriers to reduce the cost of heterospecific matings. Using assays of sperm competition within and between two sister species, we show a signature of reinforcement where these species interact: populations of Drosophila pseudoobscura that co-occur with sister species D. persimilis have an elevated ability to outcompete heterospecific sperm, consistent with selection for increased postcopulatory isolation. We also find these D. pseudoobscura populations have decreased sperm competitive ability against conspecifics, reducing the opportunity for sexual selection within these populations. Our findings demonstrate that direct selection to increase reproductive isolation against other species can compromise the efficacy of sexual selection within species, a collateral effect of reproductive traits responding to heterospecific interactions.
(400872) David Neave
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Angular momentum redistribution by mixed modes in evolved low-mass stars. II. Spin-down of the core of red giants induced by mixed modes
Creators: name: Belkacem, K.
name: Marques, J. P.
name: Goupil, M. J.
name: Mosser, B.
name: Sonoi, T.
name: Ouazzani, R. M.
name: Dupret, M. A.
name: Mathis, S.
name: Grosjean, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The detection of mixed modes in subgiants and red giants by the CoRoT and \emph{Kepler} space-borne missions allows us to investigate the internal structure of evolved low-mass stars. In particular, the measurement of the mean core rotation rate as a function of the evolution places stringent constraints on the physical mechanisms responsible for the angular momentum redistribution in stars. It showed that the current stellar evolution codes including the modelling of rotation fail to reproduce the observations. An additional physical process that efficiently extracts angular momentum from the core is thus necessary. Our aim is to assess the ability of mixed modes to do this. To this end, we developed a formalism that provides a modelling of the wave fluxes in both the mean angular momentum and the mean energy equations in a companion paper. In this article, mode amplitudes are modelled based on recent asteroseismic observations, and a quantitative estimate of the angular momentum transfer is obtained. This is performed for a benchmark model of 1.3 $M_{\odot}$ at three evolutionary stages, representative of the evolved pulsating stars observed by CoRoT and Kepler. We show that mixed modes extract angular momentum from the innermost regions of subgiants and red giants. However, this transport of angular momentum from the core is unlikely to counterbalance the effect of the core contraction in subgiants and early red giants. In contrast, for more evolved red giants, mixed modes are found efficient enough to balance and exceed the effect of the core contraction, in particular in the hydrogen-burning shell. Our results thus indicate that mixed modes are a promising candidate to explain the observed spin-down of the core of evolved red giants, but that an other mechanism is to be invoked for subgiants and early red giants.
description: Accepted in A&A, 7 pages, 8 figures
Technological Culture and Urban Design – A Field Research Project in Turin
Creators: name: Toni, Michela
Publisher: name: TECHNE - Journal of Technology for Architecture and Environment
Year: 2017

description: Technological culture has greatly influenced urban design in Turin throughout the various phases of its history. In this framework, theory and practice are as one, given that outstanding technical solutions make it possible to put an ‘idea’ of the city into practice. This article illustrates the research on projects developed in recent years using metal structures. The projects in question are so specific and peculiar that they have had a decisive impact on the urban structure itself.
description: TECHNE - Journal of Technology for Architecture and Environment, TECHNE 13 (2017): Theories Practice Design
A Novel Image Steganographic Approach for Hiding Text in Color Images using HSI Color Model
Creators: name: Muhammad, Khan
name: Ahmad, Jamil
name: Farman, Haleem
name: Zubair, Muhammad
Publisher: name: arXiv
Year: 2015
Subjects: subject: Multimedia (cs.MM)
subject: FOS: Computer and information sciences

description: Image Steganography is the process of embedding text in images such that its existence cannot be detected by Human Visual System (HVS) and is known only to sender and receiver. This paper presents a novel approach for image steganography using Hue-Saturation-Intensity (HSI) color space based on Least Significant Bit (LSB). The proposed method transforms the image from RGB color space to Hue-Saturation-Intensity (HSI) color space and then embeds secret data inside the Intensity Plane (I-Plane) and transforms it back to RGB color model after embedding. The said technique is evaluated by both subjective and Objective Analysis. Experimentally it is found that the proposed method have larger Peak Signal-to Noise Ratio (PSNR) values, good imperceptibility and multiple security levels which shows its superiority as compared to several existing methods
description: An easy to follow paper of 11 pages. arXiv admin note: text overlap with arXiv:1502.07808
The culture of designing and the culture of doing. The digital approach as the innovative dimension of process
Creators: name: Falotico, Antonella
Publisher: name: TECHNE - Journal of Technology for Architecture and Environment
Year: 2017

description: Due to the challenges and opportunities offered by the digital culture, it is necessary to study the role of the new information tools to understand how some of the scenarios belonging to the design practices and industrial and building culture have changed. This paper deals with the issues about the design constructability, with reference to the use of digital methodologies that encouraging collaborations, control and previsions, seem to shorten significantly the distances between design and construction.
description: TECHNE - Journal of Technology for Architecture and Environment, TECHNE 13 (2017): Theories Practice Design
Self-assembly of SDS and DTAB mixed surfactants with dyes in aqueous mixtures from Self-assembly of sodium dodecylsulfate and dodecyltrimethylammonium bromide mixed surfactants with dyes in aqueous mixtures.
Creators: name: K. M. Sachin
name: Karpe, Sameer A.
name: Singh, Man
name: Ajaya Bhattarai
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: 30699 Physical Chemistry not elsewhere classified
subject: FOS: Chemical sciences

description: Electronic Supplementary Information (ESI)
Ribosomal proteins as unrevealed caretakers for cellular stress and genomic instability
Creators: name: Zhang, Yanping
name: Kim, Tae Hyung
name: Leslie, Patrick
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Ribosomal proteins (RPs) have gained much attention for their extraribosomal functions particularly with respect to p53 regulation. To date, about fourteen RPs have shown to bind to MDM2 and regulate p53. Upon binding to MDM2, the RPs suppress MDM2 E3 ubiquitin ligase activity resulting in the stabilization and activation of p53. Of the RPs that bind to MDM2, RPL5 and RPL11 are the most studied and RPL11 appears to have the most significant role in p53 regulation. Considering that more than 17% of RP species have been shown to interact with MDM2, one of the questions remains unresolved is why so many RPs bind MDM2 and modulate p53. Genes encoding RPs are widely dispersed on different chromosomes in both mice and humans. As components of ribosome, RP expression is tightly regulated to meet the appropriate stoichiometric ratio between RPs and rRNAs. Once genomic instability (e.g. aneuploidy) occurs, transcriptional and translational changes due to change of DNA copy number can result in an imbalance in the expression of RPs including those that bind to MDM2. Such an imbalance in RP expression could lead to failure to assemble functional ribosomes resulting in ribosomal stress. We propose that RPs have evolved ability to regulate MDM2 in response to genomic instability as an additional layer of p53 regulation. Full understanding of the biological roles of RPs could potentially establish RPs as a novel class of therapeutic targets in human diseases such as cancer.
Development of biodegradable nanoparticles for targeting Tumor Associated Macrophages: synthesis, investigation of the role of the surfactant and surface decoration in complex media
Creators: name: CELLA, CLAUDIA
Publisher: name: Universit� degli Studi di Milano
Year: 2016

description: Tumor Associated Macrophages (TAMs) are involved in cancer proliferation, thus strategies to deplete them represent promising tools for chemotherapy. Pharmacological agents with multiple activities such as curcumin and RNA interference have been proposed; however their employment in therapeutics has been limited because of low systemic bioavailability. Accordingly, this thesis described as an innovative therapeutic approach for cancer treatment the development of polymeric nanoparticles (NPs) able to (i) increase pharmacokinetics properties of biomacromolecules and poor water soluble drugs, and (ii) guarantee TAMs specific targeting. The safe and versatile polymer Poly(Lactic-co-Glycolic)Acid (PLGA) has been used for the synthesis of NPs by both single (OW) and double (WOW) emulsion-solvent evaporation techniques. Different synthetic parameters have been taken into consideration, with particular focus on the surfactant role. As alternative to the commonly used Poly Vinyl Alcohol (PVA), a newly synthetized polymer (amino-PVA) and Calcium Sterate (CSt) have been investigated for their ability to modulate surface charge and biocompatibility. NPs with solid or core-shell structures, whose size was tailored between 200 and 300 nm, were obtained and a thorough characterization has been performed, with the help of innovative techniques such as single particle optical extinction and scattering (SPES) method. Both amino-PVA and CSt stabilized NPs were found to be able to load curcumin and biomacromolecules, either alone or in combination. Strategies for surface decoration with the employment of D-mannose as specific molecule to guarantee TAMs recognition were proposed. Finally, cytocompatibility of the amino-PVA and CSt stabilized NPs have been assessed.
Morphometric characterization of the limpet Patella ferruginea along the Tunisian coasts
Creators: name: TLIG-ZOUARI, Sabiha
name: RABAOUI, Lotfi
name: FGUIRI, Hosni
name: DIAWARA, Moctar
name: BEN HASSINE, Oum Kalthoum
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2011

description: The morphometry of the limpet Patella ferruginea Gmelin, 1791 was described in four dense localities along the Northern Tunisian coastline, with use of univariate and multivariate analyses. Similarly to previous studies, the present study has confirmed the morphometric plasticity of the species. It also revealed the coexistence of the two shell forms rouxi and lamarcki in the same habitat, particularly in Zembra Island. Although it was only encountered within two localities (Kelibia and Zembra), the latter shell form was the less abundant in the study area. Multivariate analyses could highlight segregation between the four examined rouxi samples which can be matched to the geographic location of the sampling localities. Similarly, segregation between the samples was also found, on the basis of the shell form. Moreover, some intra- sample heterogeneity was also detected in each shell form group. The coexistence of the two forms in the same locality seems to reflect that within a same biotope exist specific factors, e.g. the position on the substrate (slope) and the exposure of individuals (solar radiation), which are responsible for such morphological variation.
Comparison of Very Smooth Cell-Model Trajectories Using Five Symplectic and Two Runge-Kutta Integrators
Creators: name: Hoover, William Graham
name: Hoover, Carol Griswold
Publisher: name: arXiv
Year: 2015
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Time-reversible symplectic methods, which are precisely compatible with Liouville's phase-volume-conservation theorem, are often recommended for computational simulations of Hamiltonian mechanics. Lack of energy drift is an apparent advantage of such methods. But all numerical methods are susceptible to Lyapunov instability, which severely limits the maximum time for which chaotic solutions can be "accurate". The "advantages" of higher-order methods are lost rapidly for typical chaotic Hamiltonians. We illustrate these difficulties for a useful reproducible test case, the two-dimensional one-particle cell model with specially smooth forces. This Hamiltonian problem is chaotic and occurs on a three-dimensional constant-energy shell, the minimum dimension for chaos. We benchmark the problem with quadruple-precision trajectories using the fourth-order Candy-Rozmus, fifth-order Runge-Kutta, and eighth-order Schlier-Seiter-Teloy integrators. We compare the last, most-accurate particle trajectories to those from six double-precision algorithms, four symplectic and two Runge-Kutta.
description: Seventeen pages, seven figures, to appear in Computational Methods in Science and Technology
THE ROLE OF (SUB-)STELLAR COMPANIONS ON THE DYNAMICAL EVOLUTION OF PROTOPLANETARY DISCS
Creators: name: UBEIRA GABELLINI, MARIA GIULIA
Publisher: name: Universit� degli Studi di Milano
Year: 2020

description: The study of planet formation has become progressively more important in the last few years given the great number of diverse exoplanets recently discovered. It is, indeed, only by studying extrasolar planetary systems embedded in their natal (protoplanetary) discs that we can make statistical studies of the range of outcomes of the planet formation process. In particular, the discs that present a cavity (transitional discs) or a gap in the dust radial profile are related to disc clearing mechanisms by young giant planets. In this Thesis, we analyze observations taken with the most advanced telescopes (ALMA and VLT/SPHERE) combining multi-wavelength observations to discriminate between different formation processes in systems with disc sub-structures. We provide a general overview on protoplanetary discs and planets/binaries, followed by the description of dust and gas dynamics and thermal disc structure. Moreover, we describe the two most accredited scenarios of planet formation: core accretion and gravitational instability. In the second part of the Thesis, we present a work on the dust and gas cavity of the disc around CQ Tau observed with ALMA together with thermochemical models and hydro-dynamical simulations, which provide insight on a massive planet responsible for the clearing of such disc structure. Secondly, we describe an analysis done on a survey of 22 Herbig and F/G type stars imaged by SPHERE that confirms that the large near-infrared excess observed in the SEDs of Group I Herbig stars can be explained by the presence of a large gap in their discs. We spatially resolve spirals in HD 100453, HD 100546, CQ Tau; ring-like disc in HD 169142 and HD 141569; and single inclined thin disc in AK Sco and T Cha. We compare the results with ALMA and PDI observations and with simulations. Moreover, we detect and confirm the presence of a novel gravitationally bound companion to the young MWC 297 star. Finally, we describe a novel routine that exploits the known radial variation of stellar artifacts with wavelength together with the spectral slope of the star.
A Lean Approach to Enable Sustainability in the Built Environment through BIM
Creators: name: Maltese, Sebastiano
name: Moretti, Nicola
name: Re Cecconi, Fulvio
name: Ciribini, Angelo Luigi Camillo
name: Kamara, John M.
Publisher: name: TECHNE - Journal of Technology for Architecture and Environment
Year: 2017

description: Rating systems are assumed as instruments to endorse architectural quality, reliability, energy efficiency, economic convenience and finally expose a sustainability label. Moreover, these tools can be tied to a BIM model. The aim of this research is to set up a lean methodology to fulfil CESBA requirements through Construction to Operations Building information exchange – COBie in project on existing buildings adopting the BIM Bronze approach by UK Ministry of Justice - MoJ. This will allow to develop a semantic model and to extract sustainability reports in a post-construction phase, thereby minimising the cost of gathering information on existing buildings. An illustrated example regarding energy criteria of CESBA protocol will be presented to further the proposed approach.
description: TECHNE - Journal of Technology for Architecture and Environment, TECHNE 13 (2017): Theories Practice Design
Between nature and artifice
Creators: name: Lepore, Michele
Publisher: name: TECHNE - Journal of Technology for Architecture and Environment
Year: 2017

description: In the complex relationship between nature and artifice, establishing new modes of environmental balance between the anthropogenic transformations and ecosystems are established. The article, referring to the references for the basic concepts definitions of, focuses on the connections that follow one another in time from the first concepts of “conservation” by G. Pinchot to the expression “deep ecology” introduced in environmental literature on 1973 by the philosopher A. Naess, to the holistic approach of E. P. Odum, until the more famous environmentalist idea in the eighties: Gaia, ideas in economics of H. Daly, the great American economist father of the theory of sustainable development, leading to some considerations on the influences in the field of environmental design.
description: TECHNE - Journal of Technology for Architecture and Environment, TECHNE 13 (2017): Theories Practice Design
A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy
Creators: name: Kim, Sang Yong
name: Wang, Qiang
name: Lin, Sin Jin
name: Hung, Chia Yang
name: Qian, Keduo
name: Su, Wu Chou
name: Goto, Masuo
name: Hsu, Tsung I.
name: Chang, Wen Chang
name: Lai, Ming Derg
name: Wang, Yi Chang
name: Lee, Kuo Hsiung
name: Zhao, Yu
name: Hung, Jan Jong
name: Chen, Ying Jung
name: Kashiwada, Yoshiki
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Herein, we evaluated the anti-cancer effect and molecular mechanisms of a novel betulinic acid (BA) derivative, SYK023, by using two mouse models of lung cancer driven by KrasG12D or EGFRL858R. We found that SYK023 inhibits lung tumor proliferation, without side effects in vivo or cytotoxicity in primary lung cells in vitro. SYK023 triggered endoplasmic reticulum (ER) stress. Blockage of ER stress in SYK023-treated cells inhibited SYK023-induced apoptosis. In addition, we found that the expression of cell cycle-related genes, including cyclin A2, B1, D3, CDC25a, and CDC25b decreased but, while those of p15INK4b, p16INK4a, and p21CIP1 increased following SYK023 treatment. Finally, low doses of SYK023 significantly decreased lung cancer metastasis in vitro and in vivo. Expression of several genes related to cell migration, including synaptopodin, were downregulated by SYK023, thereby impairing F-actin polymerization and metastasis. Therefore, SYK023 may be a potentially therapeutic treatment for metastatic lung cancer.
The role of technological culture in the theoretical dichotomy between technique and form
Creators: name: Vitrano, Rosa Maria
Publisher: name: TECHNE - Journal of Technology for Architecture and Environment
Year: 2017

description: The technological culture explains the relationship between form and technique on the basis of a concrete and existential dimension. «The existential dimension “truth” becomes manifest in history, but its meaning transcend the historical situation. In general the concretization of the existential dimension depends on how things are made, that is, it depends on form and technology» (Schulz, 1979). In this perspective the essay explores theories and praxis of technological culture on the relationship between form and material, and between architecture and technique starting from the concept of technology: from the historical evolution of techniques and building systems to the value of innovation, probing material social and ideological issues that alternate in modern and contemporary process.
description: TECHNE - Journal of Technology for Architecture and Environment, TECHNE 13 (2017): Theories Practice Design
(400871) Jane Nicholl Neave
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
First cases of albinism recorded in the marble electric ray Torpedo marmorata (Chondrichthyes: Torpedinidae)
Creators: name: LIPEJ, Lovrenc
name: MAVRIC, Borut
name: ZIZA, Valter
name: CAPAPÉ, Christian
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2011

description: Two albinos specimens, one male and one female, of the electric marbled ray Torpedo marmorata Risso, 1810 were captured in the Slovenian marine waters, off Piran (northern Adriatic). Both specimens were juvenile, completely unpigmented on both body surfaces, with red eyes, constituting a case of total albinism. These are the first records on albinism observed to date in T. marmorata.
New Spinor Fields on Lorentzian 7-Manifolds
Creators: name: Bonora, L.
name: da Rocha, Roldao
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: This paper deals with the classification of spinor fields according to the bilinear covariants in 7 dimensions. The previously investigated Riemannian case is characterized by either one spinor field class, in the real case of Majorana spinors, or three non-trivial classes in the most general complex case. In this paper we show that by imposing appropriate conditions on spinor fields in 7d manifolds with Lorentzian metric, the formerly obtained obstructions for new classes of spinor fields can be circumvented. New spinor fields classes are then explicitly constructed. In particular, on 7-manifolds with asymptotically flat black hole background, these spinors can define a generalized current density which further defines a time Killing vector at the spatial infinity.
description: 13 pages, improved, to match the final version accepted in JHEP
CARATTERIZZAZIONE FUNZIONALE DEI MUTANTI DEL RECETTORE PER LA TIREOTROPINA (TSH)
Creators: name: GELMINI, GIULIA
Publisher: name: Universit� degli Studi di Milano
Year: 2013

description: Context: Heterozygous mutations in the TSH receptor gene (TSHR) are associated with partial TSH resistance, characterized by isolated nonautoimmune hyperthyrotropinemia (NAHT). The prevalence and management of this condition is controversial. Objective: Our objective was to investigate the prevalence and clinical impact of TSHR alterations in a large series of pediatric patients with NAHT and to dissect their mechanism of action. Design and Setting: For this prospective multicenter study, clinical data and samples were collected in the clinical units and conveyed to a centralized laboratory for analysis. Patients: Subjects included 284 unrelated patients with NAHT aged 18 yr. Exclusion criteria included thyroid dysgenesis or major associated congenital defects. Main Outcome Measures: Parameters of thyroid function, TSHR gene analysis, and TSHR functional assays were evaluated. Results: The frequency of heterozygous nonpolymorphicTSHRvariationswas11.8%.Weidentified seven previously unknown variations: a frameshift (p.Q33PfsX46), two intronic (g.IVS4+ 2A
Technical development and calibration of lipofuscin quantification for the potential use as an age estimate in snow crabs Chionoecetes opilio (Decapoda: Oregoniidae)
Creators: name: ALLAIN, Renée
name: MORIYASU, Mikio
name: CRAWFORD, Bryan
name: COURTENAY, Simon
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2011

description: This study demonstrated the presence of lipofuscin granules in the olfactory lobe cell mass (OLCM) of snow crab Chionoecetes opilio and examined whether granule quantification results are subject to methodological bias. Lipofuscin quantification in histological sections of the OLCM were compared between: 1) snow crab categories (sex and two indicators of age: size and condition of carapace (evaluated by the coloration of the carapace, presence/absence of scars and epizootic and epiphytic growth); 2) sample preparation methods; and 3) microscopic image collection parameters. No significant difference was observed in lipofuscin levels between mature males and females of similar size and carapace condition. Lipofuscin was more abundant in crabs with a decalcifying (presumably, older) carapace condition. However, larger clean-shell males did not have higher lipofuscin levels than smaller old-decalcifying-shell males. Autofluorescent intensity of granules was significantly higher in brain samples post-fixed in decalcifying solution compared to formalin fixed samples; however, lipofuscin levels did not differ. Increased exposure times to laser light of up to 120 seconds significantly decreased autofluorescent intensity of lipofuscin granules. No significant differences were observed in lipofuscin levels when varying optical section thickness or when comparing single confocal planes and stacks. Lipofuscin granule size frequency histograms showed possible image analysis limitations in terms of minimum lipofuscin granule size. These results raised concerns regarding the applicability of histological lipofuscin quantification in the OLCM of snow crabs.
An investigation into stress in state primary school teachers in Queensland
Creators: name: Zafir, Peta
Publisher: name: CQUniversity
Year: 2022
Subjects: subject: 130399 Specialist Studies in Education not elsewhere classified
subject: FOS: Educational sciences

description: The concepts, causes and indicators of stress are complex and varied. This study investigated teacher stress in a sample of 40 male and 92 female teachers from nine State Primary Schools, in the south-east region of Queensland. The survey instrument implemented in this research was a modified version of one developed by Professor Alex Wearing from the Department of Psychology at the University of Melbourne. The research questions focused on identifying the most common indicators of stress and coping strategies which were used by teachers and also their suggestions about what could be done to reduce the amount of stress associated with teaching. Disruptive classroom behaviour and excessive time demands were acknowledged as being the two most frequent indicators of stress for males and females. Coping techniques that were implemented by males and females involved increasing planning and doing what they felt was expected of them. Both male and female respondents reported the need to reduce the introduction of government policies, slow the rate of change, cancel Student Performance Standards, reintroduce corporal punishment and expulsion and review discipline policies. Females also sought support from other teachers in the school, employed positive self -reinforcement methods or avoided the situation. The alleviation of teacher stress requires adjustment at many levels. Future research needs to investigate external and internal factors affecting individuals and determine changes that need to be implemented at individual, school and education department levels.
Self-assembly of SDS and DTAB mixed surfactants with dyes in aqueous mixtures from Self-assembly of sodium dodecyl sulfate and dodecyl trimethyl ammonium bromide mixed surfactants with dyes in aqueous mixtures
Creators: name: K. M. Sachin
name: Karpe, Sameer A.
name: Singh, Man
name: Ajaya Bhattarai
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: 30699 Physical Chemistry not elsewhere classified
subject: FOS: Chemical sciences

description: Electronic Supplementary Information (ESI)
Supporting information from Linking dynamical complexities from activation signals to transcription responses.
Creators: name: Genghong Lin
name: Jiao, Feng
name: Qiwen Sun
name: Moxun Tang
name: Jianshe Yu
name: Zhou, Zhan
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: 60114 Systems Biology
subject: FOS: Biological sciences
subject: Computational Biology
subject: 10202 Biological Mathematics
subject: FOS: Mathematics

description: This file includes the derivations of mathematical equations and complete proofs of Theorem 1 and Theorem 2.
Gender und das Leisten emotionaler Unterstützung
Creators: name: Brüning, Fabian
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Social Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: Dies ist die Präregistrierung der Masterarbeitsstudie "Gender und das Leisten emotionaler Unterstützung" zu folgender Fragestellung: Unterscheiden sich cis-männliche von cis-weiblichen Personen beim Leisten emotionaler Unterstützung in Freund*innenschaften und welche Mechanismen stehen in einem Zusammenhang mit diesen Unterschieden?
ISOLATION AND DIFFERENTIATION OF STEM CELLS: SEARCHING FOR NEW MARKERS
Creators: name: BERGANTE, SONIA
Publisher: name: Universit� degli Studi di Milano
Year: 2013

description: Abstract MSCs are the most studied adult stem cells, as they can be isolated from almost any tissue, they show a good self-renewal capacity in vitro and they also possess good ?plasticity?(jiang nature). Oddly, MSCs are identified and defined by a combination of markers that are not distinctive, as they are shared by other cells including fibroblasts. Therefore, pure populations of MSCs cannot be isolated, as they are always contaminated by other adult cells that often do not possess stem cell plasticity. Thus, it would be very desirable to discover novel cell surface markers that would allow to discriminate MSCs from other cells. Moreover, new ways to control and promote cell differentiation are needed. Thus, it becomes crucial to search for new key molecules that can be modulated to increase MSCs differentiation toward the desired tissue or inhibit the differentiation when cells have to remain in an undifferentiated state. In this direction, we focused our attention on SLs, a family of lipids found in the outer leaflet of the plasma membrane and involved in many cell signaling pathways. Therefore, main aims of this work were: 1. to investigate the possible use of SLs as new surface markers for the identification, characterization and possibly isolation of human bone marrow MSCs; 2. to investigate the involvement of SLs in the preservation of the undifferentiated state of MSCs during in vitro culturing 3. to assess the possible role of SLs in the differentiation processes of MSCs upon opportune stimuli.
Stochastic pumping of a polariton fluid
Creators: name: Assmann, Marc
name: Bayer, Manfred
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We investigate the response of a polariton laser driven slightly off-resonantly using light fields differing from the routinely studied coherent pump sources. The response to driving light fields with thermal and displaced thermal statistics with varying correlation times shows significant differences in the transmitted intensity, its noise, and the position of the nonlinear threshold. We predict that adding more photons on average may actually reduce the transmission through the polariton system.
A phase 2, open-label, multicenter study of the long-term safety of siltuximab (an anti-interleukin-6 monoclonal antibody) in patients with multicentric Castleman disease
Creators: name: Qin, Xiang
name: Qi, Ming
name: Voorhees, Peter M.
name: Van Rhee, Frits
name: Kurzrock, Razelle
name: Fayad, Luis E.
name: Casper, Corey
name: Vermeulen, Jessica
name: Tromp, Brenda
name: Van de Velde, Helgi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: BackgroundMulticentric Castleman disease (MCD) is a rare, systemic lymphoproliferative disorder driven by interleukin (IL)-6 overproduction. Siltuximab, an anti-IL-6 monoclonal antibody, has demonstrated durable tumor and symptomatic responses in a multinational, randomized, placebo-controlled study of MCD.MethodsThis preplanned safety analysis was conducted to evaluate the long-term safety of siltuximab treatment among 19 patients with MCD who had stable disease or better and were enrolled in a phase-1 study and subsequent ongoing, open-label, phase-2 extension study. Dosing was 11 mg/kg administered intravenously every 3 weeks, per protocol, or every 6 weeks at the investigator's discretion. Safety monitoring focused on potential risks associated with the anti-IL-6 mechanism of action. Investigator-assessed disease control status was also documented.ResultsMedian treatment duration for the 19 patients was 5.1 (range 3.4, 7.2) years, with 14 (74%) patients treated for >4 years. Grade-≥3 adverse events (AEs) reported in >1 patient included hypertension (n = 3) and nausea, cellulitis, and fatigue (n = 2 each). Grade-≥3 AEs at least possibly attributed to siltuximab were leukopenia, lymphopenia, and a serious AE of polycythemia (n = 1 each). Hypertriglyceridemia and hypercholesterolemia (total cholesterol) were reported in 8 and 9 patients, respectively. No disease relapses were observed, and 8 of 19 patients were able to switch to an every-6-week dosing schedule.ConclusionsAll MCD patients in this extension study have received siltuximab for a prolonged duration (up to 7 years) without evidence of cumulative toxicity or treatment discontinuations and with few serious infections. All patients are alive, demonstrate sustained disease control, and continue to receive siltuximab.