cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Astyanax cocibolca Bussing 2008
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Characiformes
Characidae
Astyanax
Astyanax cocibolca

description: Astyanax cocibolca Bussing 2008. Cocibolca Tetra; Sardina, Sardina Lagunera, Sardinilla, Sabalete, Sardinita, Plateada, Tetra, Sardina del Lago Cocibolca
Vouchers: UCR 0024-016 (924), 0024-018 (1), 0061-004 (301), 0062-002 (238), 0242-007 (4), 0536-008 (42), 0538-006 (3), 0539-006 (60), 0540-005 (3), 0542-008 (3), 0547-006 (1), 0552-003 (1) and 0553-002 (1); other collections: LACM 56648-1 (1) and 56648-2 (50). Distribution: Central America; from southern Nicaragua to northern Costa Rica, Atlantic drainages; (Nicaragua) SJ, RF and LN (Atlantic); 12–31 masl; Pri, Pot. Occurrence and conservation status: Nat; DD (2020), population trend unknown. Literature: Astorqui (1975: 80, as Astyanax sp.; brief description, including illustrations and an identification key, and information on distribution and ecology), Villa (1982: 102, as Astyanax nasutus Meek 197, in part—misidentification; detailed description, including illustrations and an identification key, and information on distribution and ecology), Bussing (1998: 85, as A. nasutus —misidentification; brief description, including illustrations and an identification key, and information on distribution, with a map, and ecology; 2008: 1362; original description), Schmitter-Soto (2017: 1379; redescription, including illustrations and an identification key, and information on distribution, with a map, and ecology), Angulo et al. (2018: 1867; identification key and information on distribution) and Angulo (2021: 25; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 23, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Mechanisms of anti-melanocytic immune responses: vitiligo as a model to gain insights for the treatment of melanoma
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: When immune cells infiltrate a tumor, an assemblage of interactions takes place that results in the elimination of the developing tumor cells or the outgrowth of a clinically evident tumor. The identification of factors that control the outcome of host cell-tumor cell interactions represents an intense area of investigation since the modulation of these factors can potentially convert inflammation-induced cancer into immune-mediated tumor rejection. Our preliminary data indicate that the S100 family of proteins contribute to a physiologic anti-melanocytic response in vitiligo, an autoimmune disease in which melanocytes are destroyed. We hypothesize that innate immune genes expressed in vitiligo may provide insight into mechanisms which may enhance melanocyte destruction and therefore identify additional pathways for adjuvant therapy in melanoma. Specifically, we plan to investigate the expression patterns of the S100 family members to determine the cell types expressing these innate immune mediators. Second, we plan to investigate the direct cytotoxic effects of S100 family members on melanocytes and melanoma cell lines. We will also test the hypothesis that the S100 induction in cells identified to express these proteins is a marker of a program induced in these cells which may induce cytotoxic effector function. These approaches will test the hypothesis that the S100A7, A8 and A9 pathways play a role in promoting anti-melanocyte/melanoma immunity. We anticipate that by investigating the role of the S100 family of proteins in promoting anti-melanocyte immune responses we will identify immune pathways accessible for adjunctive immunotherapy in the approach to melanoma.
Abrodictyum pseudorigidum Bauret & Dubuisson
Creators: name: Ahamada H. Saïd
name: Sabine Hennequin
name: Germinal Rouhan
name: Jean-Yves Dubuisson
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Abrodictyum
Abrodictyum pseudorigidum

description: Abrodictyum pseudorigidum Bauret & Dubuisson
Abrodictyum pseudorigidum Bauret & Dubuisson in Dubuisson et al., Phytotaxa 284: 161 (2016). – Type: Madagascar, F. Rakotondrainibe 2708 (holo-: P00059914!).
‘ Trichomanes dregei Bosch’, Nederlandsch kruidkundig archief 4: 372 (1858). – Type: South Africa, Natal, J.F. Drège s.n. (holo-: P?, not located; iso-?: S-P-18091!). Note: Van den Bosch did not provide any description for this species but only a reference to South-African Trichomanes rigidum sensu Kunze (1836) based on specimens collected by Drège. Therefore, we cannot accept this name as valid.
Trichomanes rigidum Sw. var. lugubre H.Christ, Bulletin de l’Herbier Boissier, sér. 2 1 (9): 849 (1901).
– Type: DRC, Kisantu, J.B. Gillet s.n. (holo-: BR0000013468675!).
Trichomanes rigidum Sw. var. annobonense Brause, Botanische Jahrbücher 53: 378 (1915). – Type: Equatorial Guinea, Annobon Island, G.W.J. Mildbraed 6700 (holo-: BW200093175!).
Short description
Terrestrial or lithophytic, often near streams; thick, short and erect rhizomes with robust roots and clustered erect fronds; fronds well stipitate, up to 35 cm long, mostly triangular or less often sublanceolate to narrowly ovate, tripinnate-pinnatifid, with linear uni-veined ultimate segments; sori numerous, paratactic, cylindrical, truncated to slightly bilabiate with a slightly dilated mouth.
Global distribution
Tropical Africa, Comoros, Madagascar.
Distribution in Comoros
Anjouan, Grande Comore, Mohéli.
Additional specimens examined
COMOROS: s. loc., 1885, L.Humblot 1328 (P00139639, P00312496, P01430231, P01430232, P01526319, P01526320); s. loc., s.d., L.H.Boivin s.n. (P00301468). ANJOUAN, s. loc., May 1850, L.H.Boivin s.n. (P00139623); s. loc., 1875, M.Lavanchie s.n. (P00139638); s. loc., 1875, J.M.Hildebrandt 1793 (P00139637); Mjimandra, 1 Apr. 2011, E.Bidault et al. 109 (P02439773). GRANDE COMORE, La Convalescence, versant ouest, 23 Nov. 2002, F.Rakotondrainibe et al. 6771 (P00312031); versant ouest du volcan Karthala, bois proche de Convalescence, 24 Oct. 2008, M.Pignal et al. 3381 (P02439785), M.Pignal et al. 3391 (P02439789). MOHÉLI, Forêt de Saint Antoine, 21 Sep. 1995, N.Moulaert F.099 (P01485567); Chalet St Antoine, 5 Nov. 2008, M.Pignal et al. 3473 (P00684891).
description: Published as part of Ahamada H. Saïd, Sabine Hennequin, Germinal Rouhan & Jean-Yves Dubuisson, 2017, Disentangling the diversity and taxonomy of Hymenophyllaceae (Hymenophyllales, Polypodiidae) in the Comoros, pp. 1-53 in European Journal of Taxonomy 313 on page 10, DOI: 10.5852/ejt.2017.313, http://zenodo.org/record/896401
Astyanax nasutus Meek 1907
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Characiformes
Characidae
Astyanax
Astyanax nasutus

description: Astyanax nasutus Meek 1907. Managua Tetra; Sardina, Sardina Lagunera, Sardinilla, Sabalete, Sardinita, Plateada, Tetra, Sardina del Lago Managua
Vouchers: FMNH 5908 (14), 5909 (1) and 5910 (1). Distribution: Central America; endemic to the Lago Xolotlán (Managua), Nicaragua; (Nicaragua) LN (Atlantic); 30–31 masl; Pri, Pot. Occurrence and conservation status: Nat, End; DD (2020), population trend unknown. Literature: Meek (1907: 108; brief description, including an identification key, and information on distribution and ecology), Astorqui (1975: 85, as Hemybrycon sp.— misidentification; brief description, including illustrations and an identification key, and information on distribution and ecology), Villa (1982: 102; detailed description, including illustrations and an identification key, and information on distribution and ecology) and Schmitter-Soto (2017: 62; redescription, including illustrations and an identification key, and information on distribution, with a map, and ecology).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 23, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Political stereotyping and perceived entitativity from a terror management theory perspective
Creators: name: Rubinstein, Rachel Sarah
Publisher: name: No Publisher Supplied
Year: 2013

description: This research examined the intersection of Terror Management Theory (TMT) (J. Greenberg, T. Pyszczynski, & S. Solomon, 1986; S. Solomon, J. Greenberg, & T. Pyszczynski, 1991) with stereotyping of and perceived entitativity of political groups. Three hypotheses were tested.  The first was that mortality salience would engender stereotyping of conservative Republicans and liberal Democrats.  The second was that mortality salience would increase the perceived entitativity of conservative Republicans and liberal Democrats.  The final hypothesis was that perceived entitativity would mediate the proposed relationship between mortality salience and stereotyping.  Although none of these hypotheses were supported, findings revealed that overall, liberal Democrats were stereotyped more than were conservative Republicans.  Specifically, conservative Republican participants stereotyped the liberal Democrat target group significantly more than the conservative Republican target group, while moderate participants and liberal Democrat participants did not stereotype either target group significantly more than the other.
Comparing the conditions and design of stormwater detention basins built between 19&0 and 2011 to estimate service life
Creators: name: Salisbury, Allyson Brooks
Publisher: name: No Publisher Supplied
Year: 2013

description: Stormwater detention basins have been utilized for stormwater management for over 40 years. During this time, regulatory and technological changes have made older detention basin designs obsolete. Additionally little is known about the longevity of the physical and biological components of these systems. To gain a better understanding of the potential service life of detention basins this thesis compares conditions at basins built between 19&0 and 2011. The study specifically examines soil infiltration rate, the ability of older designs to fulfill new regulatory requirements, the condition of concrete structures, and the diversity of plant communities in Middlesex and Mercer Counties, New Jersey detention basins. Basin age had little effect on the soil infiltration rates. Basins built before 2004 are able to meet their original peak flow reduction standards however overall they cannot meet New Jersey’s 2004 peak flow, groundwater recharge, or water quality requirements. Age also had little effect on the condition of concrete structures in the detentions basins and on maintenance concerns such as sediment accumulation. There was a weak negative correlation between basin age and plant diversity. Additionally, plant growth was strongly associated with sediment clogging in inlets. Overall, research suggests that with proper maintenance, after 30 years detention basins can continue to perform their original functions. However new standards may necessitate basin replacement or retrofitting.
Tetramorium steinheili Forel
Creators: name: Bolton, B.
Publisher: name: Zenodo
Year: 1979
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium steinheili

description: Tetramorium steinheili Forel
(Figs 12, 15)
Tetramorium (Xiphomyrmex) steinheili Forel, 1892: 520. Syntype workers, females, Madagascar: Foret d'Andrangoloaka, confins de l'lmerina {Sikora) (MHN, Geneva) [examined].
Worker. TL 4.3 - 4.4, HL 1.00, HW 0.94 - 0.96, CI 94 - 96, SL 0.72 - 0.76, SI 77 - 80, PW 0.68 - 0.72, AL 118 - 1.20 (2 measured).
Mandibles striate; median clypeal carina sharp. Extensions of frontal carinae long and strong, slightly sinuate from origin to behind the level of the eyes and then strongly divergent, directed towards the occipital corners. Pronotum and mesonotum obtusely marginate at the sides, in dorsal view separated by an impression. Metanotal groove absent, not impressed in profile. Propodeal spines long and stout, metapleural lobes elongate-triangular, acute or blunted apically. Petiole node anteroposteriorly compressed, in dorsal view much broader than long. Dorsum of head regularly longitudinally rugulose, the alitrunk more coarsely rugose, predominantly longitudinal but the rugae meandering and with a few crossmeshes present. Pedicel and gaster unsculptured, smooth and shining. All dorsal surfaces of head and body with numerous fine, erect to suberect hairs. Leading (anterior) edges of antennal scapes with short, projecting, suberect to subdecumbent hairs which are shorter than the maximum width of the scape. Colour reddish brown, the gaster paler than the alitrunk.
In overall appearance steinheili resembles some of the members of the tortuosum-group, but the unsculptured pedicel segments and the fact that the petiole is distinctly anteroposteriorly compressed seem to indicate that the affinities of steinheili are with humbloti and its relatives. Despite this I feel that there is a distinct possibility that this species may truly be related to andrei and its allies, and convergent upon the weitzeckeri-group in pedicel structure.
Material examined
Madagascar: Andranobe, Route d'Andriamena (A. Peyrieras); Bemanevika, Souspref. Bealanana {A. Peyrieras).
description: Published as part of Bolton, B., 1979, The ant tribe Tetramoriini (Hymenoptera: Formicidae). The genus Tetramorium Mayr in the Malagasy region and in the New World., pp. 129-181 in Bulletin of the British Museum (Natural History) Entomology 38 on page 143
Robust time-series retrieval using adaptive segmental alignment
Creators: name: Shariat Talkhoonche, Shahriar
Publisher: name: No Publisher Supplied
Year: 2013

description: The problem of time-series retrieval arises in many fields of science and constitutes many important sub-problems including indexing, storage, representation, similarity measurement, etc. The center piece of time-series retrieval is, however, measurement of similarity between the query and the stored sequences in the data-base. Since different time-series sampled from similar phenomena can have variable lengths and/or warping, simple distance metrics such as Euclidean distance are either undefined or do not provide an accurate similarity measure. Therefore, alignment methods such as dynamic time warping have been proposed. They essentially rely on the distance between every sample point of contrasting sequences and recover their alignment using dynamic programming. These algorithms are effective when the sequences are noise-free and causal.    In this work we introduce the concept of segmental sequence alignment. We claim that dynamically dividing the contrasting sequences into subsequences and recovering the optimal and monotonic matching between them instead of individual time-points can result in constructing a similarity measure more robust to noise and non-causality.  We propose two different approaches and variants of them to accomplish segmental sequence alignment.     The first proposed approach is an isotonic extension of Canonical Correlation Analysis (CCA) properly constrained to satisfy the time monotonicity constraint necessary for an alignment algorithm. The second approach is an extension of pair-HMM, which is a probabilistic model for aligning sequences. We have defined a proper observation model and efficient learning and inference algorithms to jointly recover the segmentation and alignment from segmental pair-HMM. We also propose a relaxation to the probabilistic model to increase the computational efficiency.    We have shown the utility of our proposed techniques through extensive experiments on both synthetic and real-world data. We have applied our methods to various data sets from EEG signals to human activity. Our methods showed generally significant improvement over traditional models especially in instances when the sequences are corrupted by high levels of noise or are locally non-causal.
Development of micro-scale western blotting for clinical cancer diagnostics
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Although the success of modern medicine is largely predicated on understanding how groups of people respond to a treatment or intervention, it is apparent that there is significant individual variation that can lead to treatment failure or missed diagnoses. Thus, one of the most widely anticipated changes in modern healthcare is the deployment of personalized medicine strategies in the diagnosis and treatment of diseases, such as cancer. Two key advances have driven the field. First, DNA sequencing has identified differences among cancer genomes. Second, elucidation of the molecular mechanisms of disease has identified novel targets for therapy. Personalized medicine is particularly valuable in cancer treatment, since there is significant genetic heterogeneity among cancers that are morphologically and clinically similar. In some cases, patient care can be stratified on the basis of DNA sequence differences (e.g., K-ras). However, it is likely that differences in protein levels, protein activity or in the post-translational modification of proteins are better predictors of biological differences, because these bio-molecular differences are more closely linked to function. While DNA sequence information can be very accurately determined in the modern clinical diagnostics laboratory, differences in the proteome (e.g., the level of protein expression or the extent of modification) are not as easy to measure accurately and reproducibly. Currently, there is a heavy reliance on immunohistochemistry, which is fraught with quality control problems and is semi-quantitative at best. Thus, in this proposal we seek to combine lasercapture micro-dissection of tissue sections with a micro-scale western blotting technology to quantitate protein expression in very small cancer tissue samples. We propose to use this seed funding to develop and test proto-type devices. In future studies, we will apply this technology to the molecular profiling of human prostate cancers, to determine if it can be used to predict tumor behavior.
Characterization of human committed T cell progenitors capable of enhancing immune reconstitution post stem cell transplantation
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The overall goal of our research is to understand the molecular mechanisms of stem cell fate decisions - how does a stem cells decide what mature cell type it will differentiate into? Leukemias and lymphomas are cancers of the blood system. Specific types of blood cancers have been shown to arise during stem cell maturation into specialized cells, and it is likely that errors in this maturation process is the cause of a wide range of other cancers as well. Blood stem cells are responsible for generating a stable and lifelong supply of mature blood cells. Each stem cell is capable of making all of the mature blood cell types with widely different functions: some blood cells specialize in carrying oxygen, others fight off infections, and others yet prevent bleeding in the process of blood clotting. We want to understand how stem cells make the decision to become a particular type of mature blood cell, and how this process goes wrong to cause cancer. The packaging of DNA into chromatin regulates gene expression and determines the identity of different cell types. In this proposal, we will investigate how chromatin structure changes as blood stem cells differentiate into mature cells. We will use chromatin immunoprecipitation experiments and whole-genome sequencing to map chromatin modifications to specific genomic sites. Bioinformatic analyses will be used to correlate chromatin modifications with gene expression and cellular function. In addition, we will identify candidate regulators of stem cell chromatin structure. The results will improve the understanding of normal blood cell development, carcinogenesis, and mechanisms of stem cell transplantation. The long-term goal is to be able to prevent, detect, and cure blood related disorders such as leukemia and lymphoma.
Crepidomanes C. Presl (Presl 1849
Creators: name: Ahamada H. Saïd
name: Sabine Hennequin
name: Germinal Rouhan
name: Jean-Yves Dubuisson
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Crepidomanes

description: Genus Crepidomanes (C. Presl) C.Presl (Presl 1849)
This genus is mostly paleotropical with more than 25 species including two taxa in Americas (Dubuisson et al. 2013b). All species are epiphytic or lithophytic, dwarf to medium-size plants characterized by long-creeping, filiform and rootless rhizomes bearing pending flabellate (for the smallest) to highly divided (for the largest) fronds. The marginal sori have a tubular base and lips more or less developed (see Fig. 2C). In addition, laminae often exhibit false veins (Fig. 2E) or folds imitating veins.
description: Published as part of Ahamada H. Saïd, Sabine Hennequin, Germinal Rouhan & Jean-Yves Dubuisson, 2017, Disentangling the diversity and taxonomy of Hymenophyllaceae (Hymenophyllales, Polypodiidae) in the Comoros, pp. 1-53 in European Journal of Taxonomy 313 on page 10, DOI: 10.5852/ejt.2017.313, http://zenodo.org/record/896401
Additional file 6: Figure S5. of Temporal and spatial distribution of lumpy skin disease outbreaks in Ethiopia in the period 2000 to 2015
Creators: name: W. Molla
name: M. De Jong
name: K. Frankena
Publisher: name: Figshare
Year: 2017
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: LSD outbreak forecasts based on Holt-Winters analysis for January 2016 to December 2018. (DOCX 24 kb)
The spirodiepoxide
Creators: name: Sharma, Rojita
Publisher: name: No Publisher Supplied
Year: 2013

description: Revealed are studies on the reactivity and mechanism of spirodiepoxides and their utilization in the synthesis of highly functionalized diverse motifs. New spirodiepoxide based methodologies have been discussed including the method for synthesis of syn substituted hydroxyketone, diendiol, diyndiol, α′-hydroxy-γ-enone, dihydrofuranone, butenolide, and δ-lactone. Two complementary and stereochemically divergent methods for the synthesis of oxetan-3-ones starting from allenes via spirodiepoxides are also presented. Spirodiepoxide based cascades have also been used in the studies towards the synthesis of pectenotoxin 4 (PTX4). An unprecedented hydrogen bond directed allene epoxidation and spontaneous opening of the spirodiepoxide by the free hydroxyl group was employed in the synthesis of the F ring of PTX4. Improved protocol for the synthesis of allene and a new method for the synthesis of bromohydroxyketone have also been disclosed.
Investigating the role of content knowledge, argumentation, and situational features to support genetics literacy
Creators: name: Shea, Nicole Anne
Publisher: name: No Publisher Supplied
Year: 2013

description: Science curriculum is often used as a means to train students as future scientists with less emphasis placed on preparing students to reason about issues they may encounter in their daily lives  (Feinstein, Allen, & Jenkins, 2013; Roth & Barton, 2004). The general public is required to think scientifically to some degree throughout their life and often across a variety of issues. From an empirical standpoint, we do not have a robust understanding of what scientific knowledge the public finds useful for reasoning about socio-scientific issues in their everyday lives (Feinstein, 2011). We also know very little about how the situational features of an issue influences reasoning strategy (i.e., the use of knowledge to generate arguments). Rapid advances in science - particularly in genetics - increasingly challenge the public to reason about socio-scientific issues. This raises questions about the public’s ability to participate knowledgeably in socio-scientific debates, and to provide informed consent for a variety of novel scientific procedures. This dissertation aims to answer the questions: How do individuals use their genetic content knowledge to reason about authentic issues they may encounter in their daily lives? Individuals' scientific knowledge is a critical aspect of scientific literacy, but what scientific literacy looks like in practice as individuals use their content knowledge to reason about issues comprised of different situational features is still unclear. The purpose of this dissertation is to explore what knowledge is actually used by individuals to generate and support arguments about a variety of socio-scientific issues, and how the features of those issues influences reasoning strategy. Three studies were conducted to answer questions reflecting this purpose. Findings from this dissertation provide important insights into what scientific literacy looks like in practice.
Tetramorium tortuosum
Creators: name: Bolton, B.
Publisher: name: Zenodo
Year: 1979
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium tortuosum

description: The tortuosum -group
Antennae with 11 segments, the sting appendage spatulate. Petiole nodiform; one or both pedicel segments with rugose or rugulose sculpture in all Malagasy and New World species. Mandibles sculptured. Large species usually with HW> 0.80, rarely less. Legs usually with dense or fairly dense pilosity which is suberect to subdecumbent on the dorsal (outer) surfaces of the middle and hind tibiae.
Within the genus Tetramorium this is the largest species-group with 11 - merous antennae. The group is represented by about 25 species in the Old World tropics and subtropics, and 7 of these species occur only in Madagascar.
description: Published as part of Bolton, B., 1979, The ant tribe Tetramoriini (Hymenoptera: Formicidae). The genus Tetramorium Mayr in the Malagasy region and in the New World., pp. 129-181 in Bulletin of the British Museum (Natural History) Entomology 38 on page 143
Additional file 8: Table S2. of Temporal and spatial distribution of lumpy skin disease outbreaks in Ethiopia in the period 2000 to 2015
Creators: name: W. Molla
name: M. De Jong
name: K. Frankena
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: 36 month forecast of the number of LSD outbreaks based on ARIMA (1, 1, 1) x (1, 1, 1)12. (DOCX 17 kb)
Tumor-infiltrating myeloid cells and therapeutic resistance in ovarian cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: In the complex milieu of the tumor, there are a multitude of host-derived non-malignant cells that interact with the cancer cells. Mounting evidence suggests these heterotypic interactions modulate the aggressive behaviors and therapeutic resistance of the tumor. Tumor-infiltrating myeloid cells (TIMs), including macrophages and myeloid-derived suppressive cells, are the host initial innate defense against the tumor. Yet, they are known to promote the contrary effect of cancer progression and metastasis. CSF1/CSF1R signaling pathway is critical for the differentiation and growth of TIMs. Treatment with a novel selective CSF1R kinase inhibitor GW2580 dramatically reduced the burden of TIMs in several tumor models and improved therapeutic outcome. Abundant infiltrating myeloid cells (TIMs) are present in ovarian carcinomas and malignant ascites. However, the precise identity and function of these TIMs are not understood. In this project, we will employ murine ID8 ovarian cancer model implanted in the ovarian bursa. This orthotopic, immunocompetent model recapitulates the progression of human disease, including the development of ascites and recruitment of TIMs. In the first aim, we will fully characterize the evolution and the journey of TIMs from their bone marrow origin to peripheral tumor and tissue sites. We will profile the gene expression of the isolated TIMs as well as their sensitivity to GW2580 blockade. The development of platinum-resistance in ovarian cancer presents a major therapeutic challenge that leads to the poor outcome of this disease. We and other have shown that TIMs provide a favorable environment to tumor cell by heightening tumoral angiogenesis, tissue remodeling and immune suppression. Hence, in the second aim we will assess whether blockade of TIMs recruitment by GW2580 can induce a more durable and effective response to cisplatin therapy. We will employ bioluminescence imaging to track tumor growth, dissemination and treatment response. Collectively, this proposed study aims to decipher the contribution of a dominant population of innate inflammatory cells (TIMs) to therapeutic resistance in ovarian cancer. By co-targeting tumor cells as well as the sustaining components in the tumor microenvironment, we hope to achieve more effective therapeutic strategies to surmount the lethality of ovarian carcinoma.
Sovereign credit, conflict, and international relations
Creators: name: Shea, Patrick
Publisher: name: No Publisher Supplied
Year: 2013

description: This dissertation examines why investors are willing to finance government wartime borrowing. I challenge the conventional wisdom that investors have dovish preferences by arguing that investors use the uncertainty of conflict outcomes to create lucrative investment opportunities. War lending provides benefits as well as risks to lenders, and the risks are minimized if conflict do not escalate into larger campaigns. As a result, investors will favor states that tend not escalate their conflicts.    To test my theory, I rely on both qualitative and quantitative methods. I examine two case studies to gauge international (19th century Austria) and domestic (inter-war Europe) reaction to war. I then use event study analysis to analyze sovereign markets’ reaction to the news of conflict. Finally, I analyze new data on sovereign lending to examine how sovereign credit costs affect decisions to initiate and escalate conflict. In sum, my analysis supports my theoretical assertions that sovereign  investors are not always doves, but are rather pragmatists. My findings have implications on how we analyze war finance, state capacity, and military mobilization.
The role of lipoprotein receptors in the uptake of maternally circulating beta-carotene by the developing tissues
Creators: name: Shete, Varsha V.
Publisher: name: No Publisher Supplied
Year: 2013

description: In human diet, beta-carotene is the principal source of vitamin A, which is essential for normal embryonic development. Beta-carotene supplementation in pregnant women has proven to be effective to counteract the detrimental effects of vitamin A deficiency. Our lab has unequivocally shown that, in mice, intact beta-carotene supplemented during pregnancy can cross the placenta and can be efficiently metabolized by the embryo to generate retinoids. However, the mechanisms by which beta-carotene is acquired by the developing tissues from the maternal blood and key regulators involved in such uptake are unknown. Furthermore, whether maternal dietary vitamin A intake and status influence the uptake of this carotenoid by the developing tissues has never been investigated.  Our study aimed at addressing these issues by investigating whether and how maternal vitamin A status and dietary intake affect uptake of beta-carotene by the developing tissues. Furthermore, since LDL-receptor internalizes majority of beta-carotene carrying lipoproteins, we investigated whether this receptor mediates beta-carotene uptake by maternal as well as the developing tissues.   We showed that marginal vitamin A deficient status of mothers, in the case of mice lacking the retinol esterification enzyme (LRAT) and retinol-binding protein (RBP), led to an increased beta-carotene uptake in the placenta. It also led to an altered metabolism of beta-carotene in the developing tissues. Furthermore, we demonstrated that upon beta-carotene supplementation of wild-type dams, placental transcription of chylomicron-remnant receptor LRP1 and VLDL-receptor were donwregulated.  We also showed that maternal excessive dietary vitamin A intake resulted in negligible accumulation of beta-carotene in embryos. Our data indicate that the regulation of placental lipoprotein assembly and secretion could control embryonic acquisition of beta-carotene.   We demonstrated that LDL-receptor (LDLr) may partially mediate the  beta-carotene uptake in maternal liver. Under the conditions of higher serum lipoprotein accumulation, in the case of mice lacking LDLr, it may facilitate placental beta-carotene uptake. Our preliminary data suggested that regulation of placental lipoprotein assembly and secretion may control the transfer of beta-carotene to the embryo in absence of both maternal and placental LDLr. Overall, these findings expanded our knowledge of mechanisms and key regulators of beta-carotene uptake in the developing tissues.
Targeting base excision repair of oxidative DNA damage with small molecules
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: New targets for cancer chemotherapeutics and new approaches for identifying molecular targets are important areas in modern cancer research. DNA repair plays an important role in maintaining genome stability and preventing mutagenesis and carcinogenesis. However, inhibition of DNA repair enzymes may also be exploited for therapeutic purposes. The objective of this proposal is to develop mammalian cell-based assays that will used to screen small molecules libraries to identify inhibitors of the base excision repair glycosylases hOGG1 and MUTYH involved in the repair of 8- oxoguanine (OG). Oxidative base-damage occurs under conditions of oxidative stress, and hOGG1 and MUTYH prevent mutations by initiating base excision repair by removal of OG from OG:C and A from OG:A base pairs, respectively. Cellular assays will utilize a luciferase reporter that contains either an OG:C and OG:A base-pair such that repair results in luciferase activity that can be monitored in a high through-put multi-well plate format. Inhibition of the repair of the relevant OG-containing mismatch will be evaluated using the chemical screening facility at UCSC with a 20,000 compound library. After initial screening, hits will be evaluated for their ability to inhibit the base excision activity of the relevant glycosylase in in vitro assays. Development of enzymatic assays that can be performed in a high-throughput fashion will also be an important component of initiating this line of research since this will allow for cycles of optimization of lead compounds targeted at the glycosylase. In addition to identifying potential inhibitors of these enzymes, this work may also reveal additional protein targets that influence the repair mediated by these glycosylases. These inhibitors may also be useful chemical and molecular biology tools for studying the effects of inhibition of a specific glycosylase in a cellular setting. In subsequent work, novel inhibitors may be examined in cancer cell lines with various repair defects to determine if these inhibitors are cytotoxic to these cells or enhance the sensitivity to other DNA repair inhibitors or oxidative stress. In addition, the small molecules inhibitors may be used as sensitizers in conjunction with DNA damaging chemotherapeutic agents or radiation therapy.
Additional file 7: Figure S6. of Temporal and spatial distribution of lumpy skin disease outbreaks in Ethiopia in the period 2000 to 2015
Creators: name: W. Molla
name: M. De Jong
name: K. Frankena
Publisher: name: Figshare
Year: 2017
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: ACF (A) and Partial ACF (B) correlogram after first order seasonal and trend differencing of the original LSD outbreak time series. (DOCX 21 kb)
DOE Next Generation Internet: Applications, Network Technology, and Network Testbed Partnerships Program
Creators: name: Hammond, Steve
name: Williams, Dean
name: Feng, Wu
name: Foster, Ian
name: Hibbard, Bill
name: Kesselman, Carl
name: Shoshani, Arie
name: Tierney, Brian
Publisher: name: Zenodo
Year: 1999

description: The need to evaluate climate change scenarios under the Kyoto accord makes climate modeling a mission critical application area. DOE’s Accelerated Climate Prediction Initiative (ACPI) seeks to address this need through the creation of an advanced climate simulation program, which will accelerate the execution of climate models one hundred-fold by 2005 relative to the execution rate of today’s climate models [ACPI98]. High-resolution, long-duration simulations performed under ACPI will produce tens of petabytes of output. The output in turn will be made available to global change impacts researchers nationwide through a network of diagnostic and regional climate centers [ACPI98, GATE99]. These distributed centers, users, models, and data will be connected in a virtual collaborative environment called the Earth System Grid (ESG). The Earth System Grid will provide scientists with virtual proximity to the distributed data and resources comprising this collaborative environment.
Crepidomanes minutum var. mascarenensis Pynee & Dubuisson
Creators: name: Ahamada H. Saïd
name: Sabine Hennequin
name: Germinal Rouhan
name: Jean-Yves Dubuisson
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Crepidomanes
Crepidomanes minutum
Crepidomanes minutum (blume) k.iwats. var. mascarenensis pynee & dubuisson

description: Crepidomanes minutum (Blume) K.Iwats. var. mascarenensis Pynee & Dubuisson
Crepidomanes minutum (Blume) K.Iwats. var. mascarenensis Pynee & Dubuisson in Pynee et al., Phytotaxa 62: 28 (2012). – Type: Mauritius, Mt. Lagrave, 18 Jan. 1974, D. Lorence s.n. (holo-: MAU- 0009282!).
Short description
Epiphytic; long-creeping filiform rhizomes, rootless and densely covered by dense black trichomes, bearing widely separated pending fronds; fronds with terete wingless stipes, and rare proliferation, up to 2.5 cm long, flabellate, palmatisect to digitate (less often pinnatifid), with sometimes, when dry, folds parallel to veins; sori few, paratactic, tubular to funnelform with a slightly dilated mouth.
Global distribution
Western Indian Ocean (the type variety is widespread from Africa to Pacific islands).
Distribution in Comoros
Anjouan, Grande Comore, Mayotte.
Additional specimens examined
COMOROS: ANJOUAN, s. loc., 1850, L.H.Boivin s.n. (P00139635). GRANDE COMORE, Forêt de la Grille, May 1963, J.Bosser 17982 (P00139636). MAYOTTE, s. loc., 1882, E.Marie s.n. (P00139634).
Note
The dwarf C. minutum (with digitate to flabellate fronds that rarely exceed 3 cm long) is usually distinguished by the presence of buds on stipes which can develop to provide a new frond, a feature called ‘stipe proliferation’ (the synapomorphy of sect. Gonocormus; Ebihara et al. 2006). However, the Comorian specimens do not exhibit such features. They could thus correspond to C. minutum var. mascarenensis that describes lowland populations of dwarf specimens without proliferation (Pynee et al. 2012).
description: Published as part of Ahamada H. Saïd, Sabine Hennequin, Germinal Rouhan & Jean-Yves Dubuisson, 2017, Disentangling the diversity and taxonomy of Hymenophyllaceae (Hymenophyllales, Polypodiidae) in the Comoros, pp. 1-53 in European Journal of Taxonomy 313 on pages 12-13, DOI: 10.5852/ejt.2017.313, http://zenodo.org/record/896401
Cellular localization of aquaporin water channels in human glial tumors
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Brain cancer and specifically tumors arising from glia are characterized by prominent macrophage infiltration and edema. Rather than eradicate the tumor, tumor associated macrophages (TAMs) are purported to promote tumor growth. In part, this is due to the immunoregulatory properties of glial tumor cells that redirect activated macrophages from destructive pro-inflammatory functions toward anti-inflammatory "wound-healing" functions. We and others have demonstrated that non-cancerous astroglial cells inhibit pro-inflammatory macrophage activation in normal brain. Studies by others have demonstrated that glial tumor cells exert similar anti-inflammatory effects on macrophages. Here, we seek to explore if there is a link between the mechanisms causing edema and the regulation of macrophage function within tumors. The edema that accompanies brain tumor growth leads to damage of noncancerous brain tissue because the skull physically limits edema-associated brain swelling, causing compression induced tissue damage. The cause of glial tumor associated edema has been linked to elevated expression of aquaporin (AQP) water channel proteins. AQPs 1&4 regulate water transport in the healthy brain and are also expressed at elevated levels in many brain tumors. AQP4 is expressed by subsets of astroglial cells in healthy brain and by subsets of unidentified tumor cells in glial tumors. In vitro and in vivo studies have demonstrate that elevated AQP4 expression increases cell proliferation, cell motility and tumor invasiveness. It is unexamined if AQP expression alters astroglial/glial tumor regulation of macrophage function. However, increased macrophage accumulation is reported in tumor regions with increased expression of AQP4, VEGF and macrophage inhibitory factor. We propose two aims: Aim 1) Using immunohistochemical methods, we will determine (a) the localization of AQPs as a function of tumor grade, cell-type and degree of macrophage infiltration; (b) whether AQP expression correlates with macrophage expression of pro- vs. anti-inflammatory markers in human tumor samples with histologically verified diagnoses. Aim 2) Using glial tumor cell lines and primary astroglial cells, we will manipulate AQP expression and test the consequences of AQP expression on macrophage activation in co-culture systems.
Additional file 1: of Oncology practitionersâ   perspectives and practice patterns of post-treatment cancer survivorship care in the Asia-Pacific region: results from the STEP study
Creators: name: Chan, Raymond
name: Yates, Patsy
name: Qiuping Li
name: Komatsu, Hiroko
name: Lopez, Violeta
name: Myat Thandar
name: Chacko, Selva
name: So, Winnie
name: Kanaungnit Pongthavornkamol
name: Myungsun Yi
name: Pongpak Pittayapan
name: Butcon, Jessica
name: Wyld, David
name: Molassiotis, Alex
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Survivorship care items included in the questionnaire. (DOC 44 kb)
Insanity on the move
Creators: name: Shin, Ji-Hye
Publisher: name: No Publisher Supplied
Year: 2013

description: This dissertation examines the “alien insane” and their place in modern America between 1882 and 1930. It makes original contributions using the “alien insane”—allegedly insane immigrants, who were at once objects of medical surveillance and candidates of deportation, hospital commitment, and citizenship—as an analytical tool to examine how “insanity,” a diagnostic category, became understood as a bureaucratic and racial construction. It also sheds light on the contested interpretations of insanity, the development of American immigration policy and federal powers, and the involvement of state and medical bureaucracies in defining American citizenship. The “alien insane” were deeply implicated in the Progressive discourses of civilization and mobility. Analysis of the discourses explains why and how immigration came to be associated with insanity at this particular moment in American history when the field of psychiatry was professionalized and the public anxiety over new immigration grew. In addition to drawing the line between civilized and settling Europeans and uncivilized and sojourning Asians, these discourses revealed the contemporary racial ideology and gave a new meaning to immigrants’ mobility, which has been taken for granted in immigration studies. Through the “alien insane,” federal, state, and international governments as well as immigration officials, state hospital doctors, social workers, steamship companies, and immigrant communities joined to define “normal” behavior and worthy citizenship. Unlike other deportees, the “alien insane” required costly institutionalization and humanitarian attention; thus, their reception and care raised questions on the definition of citizenship for immigrants and for American citizens abroad, themselves subject to deportation by foreign states upon leaving their homeland. Moving beyond the immigration stations where historians most commonly encounter immigrant subjects, this study employs neglected and previously unavailable sources, including immigrant patient files of state mental hospitals, to investigate racialization and institutionalization of the “alien insane.” Narratives by American authors and by immigrants also help reexamine immigrants’ perspectives of insanity, assimilation, and American life. This study is about the “alien insane,” but it is also about the work they performed for American culture, for immigration policy, and for both sending and receiving countries to set national boundaries and define good citizens.