cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Start@unito as Open Educational Practice in Higher Education
Creators: name: Marchisio, Marina
name: Rabellino, Sergio
name: Sacchet, Matteo
Publisher: name: Journal of e-Learning and Knowledge Society
Year: 2020

description: Open Educational Practices mainly refer to the use of Open Educational Resources, the adoption of innovative pedagogical models, and educators and learners’ engagement in both formal and non-formal learning settings (Cronin & MacLaren, 2018; Koseoglu & Bozkurt, 2018). There are many experiences of open education context all over the world, and international organizations are redefining concepts of education that contribute to a change of perspective (UNESCO, 2019). In the context of open education, start@unito is an experience that delivers 50 open online courses in a Digital Learning Environment. Moreover, start@unito teaching practices are devoted to improving actual and prospective university students’ learning and training, using innovative methodologies, like automatic formative assessment and adaptive teaching and learning, and technology, with advanced tools connected via an integrated system. This research analyzes the model of start@unito to show that it falls under the Open Educational Practices. The analysis compares the pedagogical strategies and evaluates adherence to the international OpenEdu Framework (Inamorato dos Santos et al., 2016). Quantitative and qualitative data promote the positivity of the start@unito experience. This research will show how such a model can improve OEP because of some of its peculiarities, such as the continuous availability and the use of adaptive methodologies.
description: Journal of e-Learning and Knowledge Society, Vol 16 No 4 (2020): Journal of e-Learning and Knowledge Society - Special Issue on "Open Teaching"
Wikipedia as OER: the “Learning with Wikipedia” project
Creators: name: Petrucco, Corrado
name: Ferranti, Cinzia
Publisher: name: Journal of e-Learning and Knowledge Society
Year: 2020

description: The paper presents the results of the “Learning with Wikipedia” project which involved 1200 students and 30 faculty members at the University of Padova in creating and expanding encyclopedia articles on various subject-specific topics. Teaching activities were developed which considered Wikipedia not so much as a container for Open Educational Resources, but as a true learning environment, well organized with precise rules that can stimulate instructors to adopt Open Educational Practices. Students attended workshops where they were introduced to the project’s aims, the competences expected of them, and the procedures for contributing to the encyclopedia. One of the most significant points that emerged during the project was the importance of stimulating the full set of digital competences (for example finding and evaluating information). Gaining these competences is essential for the activities’ success and for participating, now and in the future in an extended community based on OER. That's why we investigated students’ and instructors’ perceptions regarding a set of digital competences gained by working with Wikipedia. The project was also able to make students and instructors understand that writing encyclopedia articles is not a mere academic exercise, but is a Service Learning activity that benefits the entire community, and that Wikipedia should be considered as a participatory social process and not just as a means of learning subject-specific content.
description: Journal of e-Learning and Knowledge Society, Vol 16 No 4 (2020): Journal of e-Learning and Knowledge Society - Special Issue on "Open Teaching"
Self-directed open educational practices for a decolonized South African curriculum: a process of localization for learning
Creators: name: Olivier, Jako
Publisher: name: Journal of e-Learning and Knowledge Society
Year: 2020

description: This conceptual article explores self-directed localized open educational practices for a decolonized South African higher education curriculum. From the historical context, language demography and especially due to student protests regarding the curriculum the need for a decolonized South African curriculum is evident. In this article, an overview is presented about the context-specific issues in relation to decolonization and language. It is proposed that in order to move towards a decolonized South African curriculum, there should be a self-directed learning approach to open educational practices which would involve carefully planned and supported localization efforts. This process also implies acknowledging both internal and external localization as done in a structured or even student-driven manner. Furthermore, localization means drawing on translations study theories pertaining to specifically dynamic equivalence. This approach would require increasingly accommodating languages other than English in the higher education context and as such language attitude planning efforts are needed. Finally, open educational practices would require an open ongoing process which provides agency to South African teachers and students to use the language of their choice to engage with content applicable and relevant to their contexts. In addition, this would imply including indigenous knowledge in order to address the needs of a decolonized curriculum. In conclusion, this article presents some practical recommendations towards self-directed localized open educational practices for a decolonized South African higher education curriculum.
description: Journal of e-Learning and Knowledge Society, Vol 16 No 4 (2020): Journal of e-Learning and Knowledge Society - Special Issue on "Open Teaching"
DEPIT application: open and shared digital artefacts for visible design
Creators: name: Laici, Chiara
name: Pentucci, Maila
Publisher: name: Journal of e-Learning and Knowledge Society
Year: 2020

description: In the complex contexts of nowadays classes, there is the need for a Learning Design not limited to linearize both objectives and contents, but that is guide, orientation, support to the teaching-learning process. This contribution describes the implementation of DEPIT app for learning design, developed as a part of a project financed by the European Community and carried out by three networks of schools and 4 universities through DBIR methodology. This app produces visual, digital and multimodal design artefacts, which can be used with students in a classroom during the action and shared with a community of teachers. According to OER principles, this app is internationally disseminated through a MOOC available on a European platform. Teachers' design becomes common heritage (Open Educational Practices) between teachers and students and it is replicable and reusable in different contexts. The experimentation of this app highlighted its transformative feature in comparison with the teachers' design practices, which become explicit, sustainable and shared with students.
description: Journal of e-Learning and Knowledge Society, Vol 16 No 4 (2020): Journal of e-Learning and Knowledge Society - Special Issue on "Open Teaching"
A competition of secondary and primary nucleation controls amyloid fibril formation of the parathyroid hormone
Creators: name: Voigt, Bruno
name: Ott, Maria
name: Balbach, Jochen
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 530

description: Functional amyloids belong to an increasing class of non-toxic biologic material, in contrast to the prominent disease-related amyloids. Herein, this work reports on the fibril formation of the parathyroid hormone PTH84 as a representative candidate following the same generic principles of primary and secondary nucleation. Employing Thioflavin T monitored kinetics analyses and negative-staining transmission electron microscopy, an intricate, concentration dependent behavior of time dependent generation and morphologies of PTH84 fibrils are found. While at low peptide concentrations, fibril formation is driven by surface catalyzed secondary nucleation, an increased amount of peptides cause a negative feedback on fibril elongation and secondary nucleation. Moreover, the source of primary nuclei is found to regulate the overall macroscopic fibrillation. As a consequence, the concentration dependent competition of primary versus secondary nucleation pathways is found to dominate the mechanism of fibril generation. This work is able to hypothesize an underlying monomer-oligomer equilibrium providing high-order species for primary nucleation and, additionally, negatively affecting the available monomer pool.
An Open and Multi-Layer Web Platform for Higher Music Education
Creators: name: Baratè, Adriano
name: Ludovico, Luca Andrea
Publisher: name: Journal of e-Learning and Knowledge Society
Year: 2020

description: This paper describes an open platform for the advanced experience of music information. Based on the IEEE 1599 standard, such an environment supports an integrated and synchronized multi-layer description of music pieces. This approach can be particularly suitable in higher music education, where the structured organization of a multiplicity of free resources can foster advanced and engaging learning activities. After addressing the subject of openness in music education and introducing the key features of the IEEE 1599 format, some clarifying examples and educational scenarios will be discussed.
description: Journal of e-Learning and Knowledge Society, Vol 16 No 4 (2020): Journal of e-Learning and Knowledge Society - Special Issue on "Open Teaching"
Open pedagogy practices: a case study in undergraduate education
Creators: name: Paviotti, Gigliola
name: D'Angelo, Ilaria
name: Giaconi, Catia
name: Cavicchi, Alessio
Publisher: name: Journal of e-Learning and Knowledge Society
Year: 2020

description: The study reports about an open education practice in undergraduate education, by analysing the openness of a course in which the teacher was not a ‘self-declared’ open educator. It explores data from involved educators, students and entrepreneurs, who participated in a project-based learning pathway carried out online. Data collection included observation of the process by an external researcher, final questionnaires and interviews to participants. Conclusions argue that open education practices (OEPs) can also be found in courses which have not been designed purposely as ‘open’, and that further work is needed to understand students’ perceptions in open practices.
description: Journal of e-Learning and Knowledge Society, Vol 16 No 4 (2020): Journal of e-Learning and Knowledge Society - Special Issue on "Open Teaching"
Power, self-esteem, and body Image
Creators: name: Körner, Robert
name: Schütz, Astrid
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 150

description: We expected power – the perceived capacity to influence others – to be an antecedent of positive body image because power is closely linked to self-esteem, which in turn is linked to body image. In a cross-sectional study (N = 318), sense of power was positively related to body appreciation and satisfaction with one’s appearance. Self-esteem partially mediated this effect. In an experimental study (N = 114), participants assigned to a high-power group indicated more body appreciation, reported more body satisfaction, and estimated themselves to be taller than participants assigned to a low-power group. Self-esteem mediated all the effects. Altogether, power affected body image directly but also indirectly through elevated self-esteem. Implications refer to clinical prevention and intervention programs.
Leave for Family Reasons
Creators: name: Daly, Mary
name: Ryu, Sunwoo
name: Polat, Ertugrul
Publisher: name: University of Oxford
Year: 2023
Subjects: classificationCode: 440799
subject: Policy and administration not elsewhere classified

description: There was an extension to the existing leave for family reasons (congé pour raisons familiales extraordinaire) for parents who needed to look after their children due to COVID-19-related circumstances
More than colonial vestige? : afternoon tea as heritage practice in Penang (Malaysia)
Creators: name: Pampus, Mareike
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 392

description: This article builds on insights from both critical heritage studies and Indian Ocean studies to argue that there is a need to delve deeply into how, by whom, and why heritage is practiced. Empirically, the practice of afternoon tea in Penang (Malaysia) provides insights into habits, manners, and customs in order to explore heritage as a social practice. Drawing on ethnographic field research on the island of Penang in Malaysia, this article demonstrates how the multiple forms, as well as the changing production, practice, and preservation, of local cultural heritage are used to strategically and situationally create identities in dependence of the “other” and in response to a national heritage narrative. In contrast to what is nowadays often considered a colonial vestige, I maintain that these cultural heritage elements are not foreign but part of specific local cultural heritages.
Glyphidrilus
Creators: name: Chanabun, Ratmanee
name: Sutcharit, Chirasak
name: Tongkerd, Piyoros
name: Panha, Somsak
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Clitellata
Haplotaxida
Glossoscolecidae
Glyphidrilus

description: Genus Glyphidrilus Type species. Glyphidrilus weberi Horst, 1889. Type species by original designation in Horst (1889: 77). Diagnosis. Prostomium zygolobous. Body shape nearly circular in cross section in anterior part, and becoming quadrangular in posterior part or behind clitellum. Anus dorsal or dorso-terminal. A longitudinal lamellar ridge at maturity from body wall on each side, in bc, through several of the clitellar segments (wi). Dorsal pores absent. Se tae four pairs per segment. Clitellum annular. Genital apertures, all minute and superficial. Male pores inconspicuous, located ventral to wi. Spermathecal pores usually all behind the testis segments. Gi in 7 or 8 sometime extending into an adjacent segment; strengthening of the musculature at the beginning of the intestine present or absent, no well marked intestinal gi. Calciferous glands absent. Sv usually short, each confined to segment of origin or one more; usually four pairs in 9-12. Holonephridia. Nephrostomes avesiculate and without sphincters or intestinal caeca. Testis and funnels free in 10 and 11; male ducts intramural. Ov fan shaped and with several egg strings. Ovisacs present or absent. Prostate glands absent. Sc adiverticulate. Distribution. The genus Glyphidrilus has widely distributed range from Tanzania in Africa to South Asia and Southeast Asia. In Asia many species were recorded from Yunnan, southwest China, Hainan, Indochina, Malaysia, Laos, Thailand, Singapore, and some Sunda Shelf islands such as Sumatra, Java, Borneo and Celebes (Horst 1893, Chen 1938, Gates 1958, 1972, Chen and Xu 1977, Shen and Yeo 2005, Chanabun et al. 2011, 2012a, b). It occurs along the river banks, lakes, canals, swamps and in paddy rice systems.
description: Published as part of Chanabun, Ratmanee, Sutcharit, Chirasak, Tongkerd, Piyoros & Panha, Somsak, 2013, The semi-aquatic freshwater earthworms of the genus Glyphidrilus Horst, 1889 from Thailand (Oligochaeta, Almidae) with re-descriptions of several species, pp. 1-76 in ZooKeys 265 on pages 8-9, DOI: 10.3897/zookeys.265.3911
The role of the tutor in the university context and in distance learning: an exploratory research
Creators: name: Vegliante, Rosa
name: Sannicandro, Katia
Publisher: name: Journal of e-Learning and Knowledge Society
Year: 2020

description: The contribution focuses on the role of the tutor in online courses also in relationship to recent Italian regulation Ministerial Decree n. 6/2019 (“Auto-evaluation, evaluation, initial and periodic accreditation of the venues and courses of study”), that has introduced concrete indications on the presence of tutors in distance learning courses. In the first part, the study examines the evolution and skills of the tutor, with relation to the international debate on the spreading of distance learning. The second part concerns an exploratory survey conducted with the aim of collect the opinions and satisfaction levels of instructors and tutors on the tools used to monitor learning and support students in online courses (MOOCs) on EduOpen portal (https://learn.eduopen.org/). The need to strengthen and rethink the role of the tutor (greater professional recognition) has increased, particularly in the context of distance learning; in many cases the tutor is the main interlocutor of the students and as a support figure for the team of instructors is at the core of processes of didactic innovation.
description: Journal of e-Learning and Knowledge Society, Vol 16 No 3 (2020): Journal of e-Learning and Knowledge Society - Regular Issue N. 3/2020
Additional file 2 of Functional implication of heat shock protein 70/90 and tubulin in cold stress of Dermacentor silvarum
Creators: name: Agwunobi, Desmond O.
name: Wang, Tongxuan
name: Zhang, Meng
name: Wang, Tianhong
name: Jia, Qingying
name: Zhang, Miao
name: Shi, Xinyue
name: Yu, Zhijun
name: Liu, Jingze
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Figure S2. Primer verification by PCR amplification of target genes (a: Dshsp90; b: Dshsp70; c: Dermacentor silvarum tubulin gene).
Atomistic MD simulations of n-alkanes in a phospholipid bilayer : CHARMM36 versus Slipids
Creators: name: Wurl, Anika
name: Ferreira, Tiago M.
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 530

description: Linear alkanes (n-alkanes) are chemically the most simple linear hydrophobic molecules in nature. Studying the incorporation of n-alkanes into lipid membranes is therefore a good starting point toward understanding the behavior of hydrophobic molecules in lipid membranes and to assess how accurately molecular dynamics models describe such systems. Here, the miscibility and structure of different n-alkanes—n-decane (C10), n-eicosane (C20), and n-triacontane (C30)—in dipalmitoylphosphatidylcholine membranes are investigated using two of the most used force fields for lipid membrane molecular dynamics simulations (CHARMM36 and Slipids). The n-alkanes are miscible in the membrane up to a critical volume fraction, ϕc, that depends on the force field interaction parameters used. ϕc is dependent on alkane chain length only for the model with more disordered chains (Slipids). Below ϕc, a comparison with 2H nuclear magnetic resonance (NMR) spectra indicates that a more realistic structure of the longer alkane molecules (C20 and C30) is obtained using the Slipids force field. On the other hand, for the shorter alkane (C10), Slipids simulations underestimate molecular order and CHARMM36 simulations enable a precise prediction of its experimental spectrum. The predicted 2H NMR spectra are highly sensitive to 1–4 electrostatic interactions, and suggest that a reduction of the partial charges of the longer alkanes and acyl chains in CHARMM36 results in a better performance. The results presented indicate that lipid membranes with incorporated alkanes are highly valuable systems for the validation of force fields designed to perform lipid membrane simulations.
The effect of positive learning culture in students’ blended learning process
Creators: name: Hung, Thai The
name: Tuyet, Nguyen Thi
name: Long, Nguyen Tien
name: Hanh, Nguyen Van
Publisher: name: Journal of e-Learning and Knowledge Society
Year: 2020

description: The aim of this study is to explore the effect of positive learning culture in students’ blended learning process. The starting point of this study is the analysis of the core values of positive learning culture and its influence on students’ learning in a blended classroom environment based on literature studies. The results of analyzing data from 339 student respondents, who experienced in a blended classroom environment where successfully established positive learning cultures led to interesting findings. The existence of a positive learning culture in blended classrooms has a positive effect on students’ learning success. The results of correlation analysis recognize that there is a positive correlation between a learning culture and the blended learning process of the students. The culture of trust and respect has a positive effect on the theory lecture and lecture notes phase of the blended learning process. The culture of independence has a positive effect on VLE and RLOs phase of the blended learning process. The culture of trust, respect, and collaboration has a positive effect on physical planning. Finally, the culture of respect and independence have a positive effect on practical labs / classrooms phase of the blended learning process. These findings provide practical implications for educators in promoting more of one or more of the core values of positive learning culture in each phase of the blended learning process.
description: Journal of e-Learning and Knowledge Society, Vol 16 No 3 (2020): Journal of e-Learning and Knowledge Society - Regular Issue N. 3/2020
Impact of tumour volume and treatment delay on the outcome after linear accelerator-based fractionated stereotactic radiosurgery of uveal melanoma
Creators: name: Sreenivasa, Shanthala
name: Wösle, Markus
name: Gager, Yann
name: Vordermark, Dirk
name: Grajewski, Luise
name: Krause, Lothar
name: Ciernik, I. Frank
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Background/aims: Primary radiation therapy is used to treat malignant uveal melanoma (UM). We report our single-centre experience with fractionated radiosurgery (fSRS) with a linear accelerator (LINAC) after specific adaptation for small target volumes with HybridArc. Methods: From October 2014 to January 2020, 101 patients referred to Dessau City Hospital with unilateral UM underwent fSRS with 50 Gy given in five fractions on five consecutive days. Primary endpoints were local tumour control, globe preservation, metastasis and death. Potential prognostic features were analysed. Kaplan-Meier analysis, Cox proportional hazards model and linear models were used for calculations. Results: The median baseline tumour diameter was 10.0 mm (range, 3.0–20.0 mm), median tumour thickness 5.0 mm (range, 0.9–15.5 mm) and median gross tumour volume (GTV) 0.4 cm³ (range, 0.2–2.6 cm³). After a median follow-up of 32.0 months (range, 2.5–76.0 months), 7 patients (6.9%) underwent enucleation: 4 (4.0%) due to local recurrence and 3 (3.0%) due to radiation toxicities, and 6 patients (5.9%) revealed tumour persistence with a GTV exceeding 1.0 cm³. Of 20 patients (19.8%) who died, 8 (7.9%) were tumour-related deaths. Twelve patients (11.9%) suffered from distant metastasis. GTV showed an impact on all endpoints, and treatment delay was associated with reduced odds of eye preservation. Conclusion: LINAC-based fSRS with static conformal beams combined with dynamic conformal arcs and discrete intensity-modulated radiotherapy results in a high tumour control rate. The tumour volume is the most robust physical prognostic marker for local control and disease progression. Avoiding treatment delay improves outcomes.
Design and development of seamless learning to improving learning outcome of Islamic economic course: a case study in Indonesia
Creators: name: Safiah, Intan
name: Degeng, I Nyoman Sudhana
name: Setyosari, Punaji
name: Ulfa, Saida
Publisher: name: Journal of e-Learning and Knowledge Society
Year: 2020

description: This research aims to develop a project-based seamless learning model that integrates formal and informal learning in the Islamic economic course, using the ADDIE model. The methods used in this study are divided into two stages. The first analyzes the expert test on the developed product model using the Content Validity Index (CVI) formula. Meanwhile, the second examines the learning outcomes data using the t-test. The expert validation showed the learning design developed is in accordance with the dimensions of Mobile Seamless Learning (MSL), and the developed Seamless learning model fulfills the requirements to be implemented in learning. Likewise, the results of the trial results showed Seamless Learning design developed can improve learning outcomes in the Islamic economic system course.
description: Journal of e-Learning and Knowledge Society, Vol 16 No 3 (2020): Journal of e-Learning and Knowledge Society - Regular Issue N. 3/2020
The Development of Lung Adenocarcinoma Model Using Transgenic Oncopigs
Creators: name: Wang, Yifan
Publisher: name: University of Illinois at Chicago
Year: 2021

description: This study aims to develop a large animal model of lung adenocarcinoma using Oncopigs. Oncopigs are genetically engineered to harbor a heterozygous transgene encoding TP53R167H and KRASG12D under Lox-STOP-Lox control. Expression of the oncogenes can be switched on by introducing Cre recombinase in targeted cells. Lung tissue was harvested from Oncopigs, and primary small airway epithelial cells were enriched via antibody-mediated magnetic bead selection. The primary Oncopig small airway epithelial cells were cultured to reach confluence prior to introducing genetic perturbations in an effort to achieve oncogenic transformation.
Overexpression of TP53R167H and KRASG12D encoded by the Oncopig transgene in small airway epithelial cells lead to cell death characterized by the accumulation of large cytoplasmic vesicles. The intracellular vesicular accumulations were confirmed to be derived from pinocytosis by a dextran incorporation assay, which highlights this particular form of cell death as methuosis. Oncogenic transformation in pig lung small airway epithelial cells cannot be achieved by only expressing the Oncopig transgene encoding TP53R167H and KRASG12D.
Lentiviral-mediated overexpression of various cell cycle regulators was explored in an effort to overcome methuosis associated with expression of the Oncopig transgene. Oncopig small airway epithelial cells transduced with CDK4, hTERT and CCND1 survived and expanded upon Cre-induced expression of TP53R167H and KRASG12D for over four months, in addition to cells transduced with only one lentiviral vector encoding CDK4R24L.
Report on Stakeholder Meeting: INFRAFRONTIER / IMPC Stakeholder Meeting: Advancing Personalised Medicine with Animal Models
Creators: name: Ali Khan, Asrar
name: Raess, Michael
Publisher: name: Zenodo
Year: 2019

description: This report describes the 2nd IPAD-MD Stakeholder Meeting that was organised on 14th - 16th November 2017 in Athens (Greece) and is the deliverable D2.3 for the IPAD-MD project (grant agreement No. 653961). The main focus of the meeting was to facilitate active discussions on the advances in CRISPR/Cas9 technology with a wide range of international INFRAFRONTIER stakeholders which included international research infrastructures for phenotyping, archiving and distribution of mouse disease models, personalised medicine initiatives, rare disease networks, funders and the INFRAFRONTIER user community.
Qualitative Analysis of Digital Technology Studies in the Field of Social and Human Sciences
Creators: name: Bonami, Beatrice
name: Nocenzi, Mariella
name: Passarelli, Brasilina
Publisher: name: Journal of e-Learning and Knowledge Society
Year: 2020

description: This paper aims to present how the topic of digital technology has been discussed in the field of sciences, especially education. At first, presents 10 theoretical categories dedicated to the study of education in interface with digital technology, extracted from the systematic review of, approximately, 2,300 scientific papers collected in two portals: CAPES and ERIC. Following, the paper presents a topical research carried out in the Department of Social Sciences of the University of Rome La Sapienza, in particular on the Sostenibilia Research Center which integrates transdisciplinary research in the interface of social sciences, digital technologies, education and sustainability. In the scope of the research, Professors and Researchers were interviewed about which categories they identify as the main trend of study about digital technologies. After selecting the category of “The Study of Technology as a New Paradigm of Post-Modern Societies” two groups of possible answers were elaborated: the first one about why that category was chosen; and the second about what are the challenges in the study of digital technologies in the field of humanities. We offer some discussion and remarks about the characteristics of digital technologies’ study among Education and Social Sciences’ field underlighting the role of Open Educational Resources (OER) to consider a new paradigm for educational technology. Nevertheless, we present the concept of OER that connects education, its diverse skills and digital technologies.
description: Journal of e-Learning and Knowledge Society, Vol 16 No 3 (2020): Journal of e-Learning and Knowledge Society - Regular Issue N. 3/2020
Mortality after radiotherapy or surgery in the treatment of early-stage non-small-cell lung cancer : a population-based data analysis in the clinical cancer registry of Brandenburg-Berlin
Creators: name: Müller, Jörg Andreas
name: Vordermark, Dirk
name: Medenwald, Daniel
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Purpose: Stereotactic body radiotherapy (SBRT) is an established treatment method with favorable toxicity for inoperable early-stage non-small-cell lung cancer (NSCLC) patients. This paper aims to evaluate the importance of SBRT in the treatment of early-stage lung cancer patients compared to surgery as standard of care. Methods: The German clinical cancer register of Berlin-Brandenburg was assessed. Cases of lung cancer were considered if they had a TNM stage (clinical or pathological) of T1-T2a and N0/x and M0/x, corresponding to UICC stages I and II. In our analyses, cases diagnosed between 2000 and 2015 were included. We adjusted our models with propensity score matching. We compared patients treated with SBRT or surgery regarding age, Karnofsky performance status (KPS), sex, histological grade, and TNM classification. Further, we assessed the association of cancer-related parameters with mortality; hazard ratios (HR) from Cox proportional hazards models were computed. Results: A total of 558 patients with UICC stages I and II NSCLC were analyzed. In univariate survival models, we found similar survival rates in patients who underwent radiotherapy compared with surgery (HR 1.2, 95% confidence interval [CI] 0.92–1.56; p = 0.2). Our univariate subgroup analyses of patients > 75 years showed a statistically nonsignificant survival benefit for patients treated with SBRT (HR 0.86, 95% CI 0.54–1.35; p = 0.5). Likewise, in our T1 subanalysis, survival rates were similar between the two treatment groups regarding overall survival (HR 1.12, 95% CI 0.57–2.19; p = 0.7). The availability of histological data might be slightly beneficial in terms of survival (HR 0.89, 95% CI 0.68–1.15; p = 0.4). This effect was also not significant. Regarding the availability of histological status in our subgroup analyses of elderly patients, we could show similar survival rates as well (HR 0.70, 95% CI 0.44–1.23; p = 0.14). T1-staged patients also had a statistically nonsignificant survival benefit if histological grading was available (HR 0.75, 95% CI 0.39–1.44; p = 0.4). Concerning adjusted covariates, better KPS scores were associated with better survival in our matched univariate Cox regression models. Further, higher histological grades and TNM stages were related to a higher mortality risk. Conclusion: Using population-based data, we observed an almost equal survival of patients treated with SBRT compared to surgery in stage I and II lung cancer. The availability of histological status might not be decisive in treatment planning. SBRT is comparable to surgery in terms of survival.
Additional file 1 of Prognosis does not change the landscape: palliative home care clients experience high rates of pain and nausea, regardless of prognosis
Creators: name: Williams, Nicole
name: Hermans, Kirsten
name: Stevens, Tara
name: Hirdes, John P.
name: Declercq, Anja
name: Cohen, Joachim
name: Guthrie, Dawn M.
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1: Table 1. Description of Clinical Assessment Protocol (CAP) triggering levels. A detailed description of how each individual Clinical Assessment Protocol (CAP) triggering level is defined.
Evaluation of water matrix effects on light-based small disinfection systems
Creators: name: Ketabchi, Faezeh
Publisher: name: University of British Columbia
Year: 2023

description: The global challenge of providing clean water supply for an increasing population is growing at an unprecedented pace. The most acute public health risk associated with drinking water is the potential presence of pathogens due to ineffective treatment. Therefore, there is an essential need for effective and efficient drinking water disinfection systems. Ultraviolet (UV) radiation and photocatalytic technologies are effective light-based disinfection methods that have grown in popularity, particularly in resource-limited scenarios. Due to increased cost, maintenance, and footprint, it is desirable to omit the filtration process in treatment systems utilizing UV for disinfection. However, understanding UV effectiveness for water treatment is primarily based on studies that have assumed pre-filtration and removal of particulates. To identify potential issues with applying UV to unfiltered water sources, this study investigated the effect of the water quality characteristics of unfiltered water samples on UV disinfection efficacy. UV biodosimetry tests were conducted over a year using water samples from two treatment plants that apply UV without filtration. The results showed that instead of typical water quality parameters such as turbidity and UV absorbance, the surface charge of particulate matter is the principal characteristic that describes UV dose-response relationships for unfiltered water sources. In terms of photocatalytic disinfection, this thesis focused on identifying possible interference of background natural organic matter (NOM) on photocatalytic disinfection via a novel metal-free visible-light active material, carbon nitride (CNx). In addition, any potential changes of the photocatalytic process on the character of background NOM was investigated using fluorescence spectroscopy. The results indicated that despite decreased inactivation efficiency of UV-LED disinfection system due to the particulate effect in unfiltered water samples, particles and NOM in real water matrices promoted viral inactivation by CNx photocatalytic disinfection. In addition, the results showed that even with low CNx concentrations (50 mg/L), the viral inactivation rate increased by 43%. Last but not least, the common regulatory drinking water treatment objective of 4-log removal of viruses can be satisfied with a far lower power light source.
Simplex didactics: promoting transversal learning through the training of perspective taking
Creators: name: Di Tore, Stefano
name: Aiello, Paola
name: Sibilio, Maurizio
name: Berthoz, Alain
Publisher: name: Journal of e-Learning and Knowledge Society
Year: 2020

description: Several studies have focused on Visual Perspective Taking (from here on out “PT”). PT refer to the capacity to elaborate space from different perspectives. Research results led to the hypothesis that such an ability constitutes a milestone in the development of an individual’s social skills, more specifically empathy, whose full development is at the basis of numerous school-related competencies. Even the national educational system seems to recognise the central role of the development of such skill in students’ learning. To date, there is a lack of studies and teaching methods specifically designed to favour an adequate development of PT. The objective of this paper is to present the results of the validation of an edugame specifically designed to measure and promote the PT skill development.
description: Journal of e-Learning and Knowledge Society, Vol 16 No 3 (2020): Journal of e-Learning and Knowledge Society - Regular Issue N. 3/2020
RUNX1 isoform disequilibrium promotes the development of trisomy 21–associated myeloid leukemia
Creators: name: Gialesaki, Sofia
name: Bräuer-Hartmann, Daniela
name: Alejo-Valle, Oriol
name: Regényi, Eniko
name: Ng, Michelle
name: Heckl, Dirk
name: Ihling, Christian
name: Sinz, Andrea
name: Glass, Max
name: Hüttelmaier, Stefan
name: [Und Viele Weitere]
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Gain of chromosome 21 (Hsa21) is among the most frequent aneuploidies in leukemia. However, it remains unclear how partial or complete amplifications of Hsa21 promote leukemogenesis and why children with Down syndrome (DS) (ie, trisomy 21) are particularly at risk of leukemia development. Here, we propose that RUNX1 isoform disequilibrium with RUNX1A bias is key to DS-associated myeloid leukemia (ML-DS). Starting with Hsa21-focused CRISPR–CRISPR-associated protein 9 screens, we uncovered a strong and specific RUNX1 dependency in ML-DS cells. Expression of the RUNX1A isoform is elevated in patients with ML-DS, and mechanistic studies using murine ML-DS models and patient-derived xenografts revealed that excess RUNX1A synergizes with the pathognomonic Gata1s mutation during leukemogenesis by displacing RUNX1C from its endogenous binding sites and inducing oncogenic programs in complex with the MYC cofactor MAX. These effects were reversed by restoring the RUNX1A:RUNX1C equilibrium in patient-derived xenografts in vitro and in vivo. Moreover, pharmacological interference with MYC:MAX dimerization using MYCi361 exerted strong antileukemic effects. Thus, our study highlights the importance of alternative splicing in leukemogenesis, even on a background of aneuploidy, and paves the way for the development of specific and targeted therapies for ML-DS, as well as for other leukemias with Hsa21 aneuploidy or RUNX1 isoform disequilibrium.
Digital technologies integration in teacher education: the active teacher training model
Creators: name: Rodrigues, Ana Luísa
Publisher: name: Journal of e-Learning and Knowledge Society
Year: 2020

description: The objective of this research was to identify the theoretical and practical bases that contribute to a model that will allow the implementation of an innovative teaching-learning model for the integration of digital technologies in teacher education. This model of teacher training, based on identified pedagogical trends, was characterised by a flexible approach to the training process, including active training strategies that encourage the acquisition of diversified skills, including digital. This approach can also transfer to students skills which enable them to take responsibility for their learning and creation of their own knowledge. The research method used was two-fold: i) action research in the development of training workshops in an in-service research training project and ii) a case study in a pre-service teacher education study, in Portugal. It was found in this study that the participating teachers were able to develop skills and integrate digital technologies in their own teaching-learning process and could change their teaching practices, which will support the development of online education in the future.
description: Journal of e-Learning and Knowledge Society, Vol 16 No 3 (2020): Journal of e-Learning and Knowledge Society - Regular Issue N. 3/2020
Perspective elucidating the physiology of a microbial cell : Neidhardt's Holy Grail
Creators: name: Sawers, R. Gary
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 570

description: A living microbial cell represents a system of high complexity, integration, and extreme order. All processes within that cell interconvert free energy through a multitude of interconnected metabolic reactions that help to maintain the cell in a state of low entropy, which is a characteristic of all living systems. The study of macromolecular interactions outside this cellular environment yields valuable information about the molecular function of macromolecules but represents a system in comparative disorder. Consequently, care must always be taken in interpreting the information gleaned from such studies and must be compared with how the same macromolecules function in vivo, otherwise, discrepancies can arise. The importance of combining reductionist approaches with the study of whole-cell microbial physiology is discussed regarding the long-term aim of understanding how a cell functions in its entirety. This can only be achieved by the continued development of high-resolution structural and multi-omic technologies. It is only by studying the whole cell that we can ever hope to understand how living systems function.
School-related Food Support
Creators: name: Daly, Mary
name: Ryu, Sunwoo
name: Polat, Ertugrul
Publisher: name: University of Oxford
Year: 2023
Subjects: classificationCode: 440799
subject: Policy and administration not elsewhere classified

description: Free school lunches as part of the Scheme 9 programme were continuously provided and delivered to eligible children's homes during school closures
A common model for tracking student learning and knowledge acquisition in different e-Learning platforms
Creators: name: Grubišić, Ani
name: Žitko, Branko
name: Stankov, Slavomir
name: Šarić-Grgić, Ines
name: Gašpar, Angelina
name: Tomaš, Suzana
name: Brajković, Emil
name: Volarić, Tomislav
name: Vasić, Daniel
name: Dodaj, Arta
Publisher: name: Journal of e-Learning and Knowledge Society
Year: 2020

description: E-Learning environment implies self-motivation and perseverance in study and completion of learning tasks. However, the more autonomy students have in managing their e-Learning, the harder they cope with distractions and remaining focused and engaged. This research study aims to assess the level of student engagement in four e-Learning platforms (CoLaB Tutor, AC-ware Tutor, CM Tutor and Moodle) in higher education. A model for Tracking Student Learning and Knowledge (TSLAK) is developed and based on two sets of variables: variables tracking student’s learning activities (VTL) and variables tracking student’s knowledge (VTK). This study aims to provide answers on how a model for tracking student online learning and knowledge can be formalized for the four e-Learning platforms and how can student learning and knowledge acquisition processes be described and measured by VTL and VTK. The results obtained by VTL and VTK indicate a significant decline in students’ engagement. Out of 218 the most engaged students, 77 (35%) of them used the CoLaB Tutor, 41 (19%) used the AC-ware Tutor, 52 (24%) used the CM Tutor, and 48 (22%) used the Moodle. The research showed that out of the total number of students only 88 (13%) of them were the most engaged and the most successful or more precisely, 63 (71%) graduates and 25 (29%) undergraduates. Such student engagement and success measured by VTL and VTK indicate the necessity of increasing students’ motivation in blended learning environments, strengthening their preparation and introduction to e-Learning platforms, and observing their feedback during a research study.
description: Journal of e-Learning and Knowledge Society, Vol 16 No 3 (2020): Journal of e-Learning and Knowledge Society - Regular Issue N. 3/2020
Impact of in vitro phytohormone treatments on the metabolome of the leafy liverwort Radula complanata (L.) Dumort
Creators: name: Blatt-Janmaat, Kaitlyn
name: Neumann, Steffen
name: Schmidt, Florian
name: Ziegler, Jörg
name: Qu, Yang
name: Peters, Kristian
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 570

description: Introduction: Liverworts are a group of non-vascular plants that possess unique metabolism not found in other plants. Many liverwort metabolites have interesting structural and biochemical characteristics, however the fluctuations of these metabolites in response to stressors is largely unknown. Objectives: To investigate the metabolic stress-response of the leafy liverwort Radula complanata. Methods Five phytohormones were applied exogenously to in vitro cultured R. complanata and an untargeted metabolomic analysis was conducted. Compound classification and identification was performed with CANOPUS and SIRIUS while statistical analyses including PCA, ANOVA, and variable selection using BORUTA were conducted to identify metabolic shifts. Results: It was found that R. complanata was predominantly composed of carboxylic acids and derivatives, followed by benzene and substituted derivatives, fatty acyls, organooxygen compounds, prenol lipids, and flavonoids. The PCA revealed that samples grouped based on the type of hormone applied, and the variable selection using BORUTA (Random Forest) revealed 71 identified and/or classified features that fluctuated with phytohormone application. The stress-response treatments largely reduced the production of the selected primary metabolites while the growth treatments resulted in increased production of these compounds. 4-(3-Methyl-2-butenyl)-5-phenethylbenzene-1,3-diol was identified as a biomarker for the growth treatments while GDP-hexose was identified as a biomarker for the stress-response treatments. Conclusion: Exogenous phytohormone application caused clear metabolic shifts in Radula complanata that deviate from the responses of vascular plants. Further identification of the selected metabolite features can reveal metabolic biomarkers unique to liverworts and provide more insight into liverwort stress responses.
Educational dinosaurs in the digital-pandemic era: the need for a digital framework and an emergency framework in education
Creators: name: Minerva, Tommaso
Publisher: name: Journal of e-Learning and Knowledge Society
Year: 2020

description: In this editorial I tell a story and indicate a point of view, a perspective. A story straddling the pandemic. A before and an after with extremely different scenarios but with identical actions on educational policies aimed at delegitimization of any digital innovation in education. The perspective is instead to integrate (mix, blend, hybridize, ...) educational activities in presence and educational activities supported by digital technologies. The pandemic has also made clear the need for a plan of actions and policies in phases of educational emergency.
description: Journal of e-Learning and Knowledge Society, Vol 16 No 3 (2020): Journal of e-Learning and Knowledge Society - Regular Issue N. 3/2020