Engineered yeasts and lignocellulosic biomaterials: shaping a new dimension for biorefinery and global bioeconomy
Creators: name: Asemoloye, Michael Dare
name: Bello, Tunde Sheriffdeen
name: Oladoye, Peter Olusakin
name: Gbadamosi, Muideen Remilekun
name: Babarinde, Segun Oladiran
name: Adebami, Gboyega Ebenezer
name: Olowe, Olumayowa Mary
name: Temporiti, Marta Elisabetta Eleonora
name: Wanek, Wolfgang
name: Marchisio, Mario Andrea
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: The next milestone of synthetic biology research relies on the development of customized microbes for specific industrial purposes. Metabolic pathways of an organism, for example, depict its chemical repertoire and its genetic makeup. If genes controlling such pathways can be identified, scientists can decide to enhance or rewrite them for different purposes depending on the organism and the desired metabolites. The lignocellulosic biorefinery has achieved good progress over the past few years with potential impact on global bioeconomy. This principle aims to produce different bio-based products like biochemical(s) or biofuel(s) from plant biomass under microbial actions. Meanwhile, yeasts have proven very useful for different biotechnological applications. Hence, their potentials in genetic/metabolic engineering can be fully explored for lignocellulosic biorefineries. For instance, the secretion of enzymes above the natural limit (aided by genetic engineering) would speed-up the down-line processes in lignocellulosic biorefineries and the cost. Thus, the next milestone would greatly require the development of synthetic yeasts with much more efficient metabolic capacities to achieve basic requirements for particular biorefinery. This review gave comprehensive overview of lignocellulosic biomaterials and their importance in bioeconomy. Many researchers have demonstrated the engineering of several ligninolytic enzymes in heterologous yeast hosts. However, there are still many factors needing to be well understood like the secretion time, titter value, thermal stability, pH tolerance, and reactivity of the recombinant enzymes. Here, we give a detailed account of the potentials of engineered yeasts being discussed, as well as the constraints associated with their development and applications. Metabolic pathways of an organism depict its chemical repertoire and its genetic makeup.Autonomous synthetic microbes can be developed for lignocellulose biorefinery (LCB).LCBs can be harnessed with synthetic microbes to boost global bioeconomy.Yeasts can be engineered to enhance downstream process of LCB. Metabolic pathways of an organism depict its chemical repertoire and its genetic makeup. Autonomous synthetic microbes can be developed for lignocellulose biorefinery (LCB). LCBs can be harnessed with synthetic microbes to boost global bioeconomy. Yeasts can be engineered to enhance downstream process of LCB.