cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Increasing Cardiomyocyte Atrogin-1 Reduces Aging-Associated Fibrosis and Regulates Remodeling in Vivo
Creators: name: Schisler, J.C.
name: Eaton, S.C.
name: Patterson, C.
name: Mota, R.
name: Sandri, M.
name: Tulasi, D.
name: Mwiza, J.M.
name: Zaglia, T.
name: Yates, C.C.
name: Willis, M.S.
name: Parry, T.L.
name: Qiang, Z.
Publisher: name: Elsevier Inc.
Year: 2018

description: The muscle-specific ubiquitin ligase atrogin-1 (MAFbx) has been identified as a critical regulator of pathologic and physiological cardiac hypertrophy; it regulates these processes by ubiquitinating transcription factors [nuclear factor of activated T-cells and forkhead box O (FoxO) 1/3]. However, the role of atrogin-1 in regulating transcription factors in aging has not previously been described. Atrogin-1 cardiomyocyte-specific transgenic (Tg + ) adult mice (α-major histocompatibility complex promoter driven) have normal cardiac function and size. Herein, we demonstrate that 18-month-old atrogin-1 Tg + hearts exhibit significantly increased anterior wall thickness without functional impairment versus wild-type mice. Histologic analysis at 18 months revealed atrogin-1 Tg + mice had significantly less fibrosis and significantly greater nuclei and cardiomyocyte cross-sectional analysis. Furthermore, by real-time quantitative PCR, atrogin-1 Tg + had increased Col 6a4, 6a5, 6a6, matrix metalloproteinase 8 (Mmp8), and Mmp9 mRNA, suggesting a role for atrogin-1 in regulating collagen deposits and MMP-8 and MMP-9. Because atrogin-1 Tg + mice exhibited significantly less collagen deposition and protein levels, enhanced Mmp8 and Mmp9 mRNA may offer one mechanism by which collagen levels are kept in check in the aged atrogin-1 Tg + heart. In addition, atrogin-1 Tg + hearts showed enhanced FoxO1/3 activity. The present study shows a novel link between atrogin-1–mediated regulation of FoxO1/3 activity and reduced collagen deposition and fibrosis in the aged heart. Therefore, targeting FoxO1/3 activity via the muscle-specific atrogin-1 ubiquitin ligase may offer a muscle-specific method to modulate aging-related cardiac fibrosis.
title: Imaging of Pulmonary Ventilation Under Free-Breathing Using Dual-Echo Ultra-Short Echo Time Sequence: A Preliminary Report
Creators: name: Sugimori, Hiroyuki
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Chronic obstructive airways disease
subject: Technical aspects
subject: Imaging sequences
subject: MR
subject: MR physics
subject: Lung

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Recent development of the pointwise encoding time reduction with radial acquisition (PETRA) [1] allows MR imaging with ultra-short echo time (TE). This technique provides high quality images of organs and tissues, free of distortions; and has been...
title: The carbon footprint of radiology - measuring energy consumption of CT scanners and identifying opportunities for energy saving
Creators: name: Heye, Tobias
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Professional issues
subject: Computer applications
subject: CT
subject: Cost-effectiveness
subject: Technology assessment
subject: Technical aspects
subject: Economics
subject: Quality assurance

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To measure the energy consumption of modern CT scanners in a university hospital radiology department and to identify energy saving potential during the clinical...
(101546) John William Partridge
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
การปฏิบัติทางการเกษตรอินทรีย์ ความได้เปรียบทางการแข่งขัน และผลการดำเนินงานด้านต้นทุนของเกษตรกรไทย
Creators: name: พิทวัส  เอื้อสังคมเศรษฐ์
Publisher: name: โรงพิมพ์แห่งจุฬาลงกรณ์มหาวิทยาลัย
Year: 2019
Subjects: เกษตรอินทรีย์
การปฏิบัติทางการเกษตรอินทรีย์
ความได้เปรียบทางการแข่งขัน
ผลการดำเนินงานด้านต้นทุน
ความยั่งยืน
Organic Agriculture
Organic Agriculture Practice
Competitive Advantage
Cost Performance
Sustainability

description: จุฬาลงกรณ์ธุรกิจปริทัศน์, 41, 160, 102-135
Optical Flashes from Internal Pairs Formed in Gamma-Ray Burst Afterglows
Creators: name: Panaitescu, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We develop a numerical formalism for calculating the distribution with energy of the (internal) pairs formed in a relativistic source from unscattered MeV--TeV photons. For GRB afterglows, this formalism is more suitable if the relativistic reverse-shock that energizes the ejecta is the source of the GeV photons. The number of pairs formed is set by the source GeV output (calculated from the Fermi-LAT fluence), the unknown source Lorentz factor, and the unmeasured peak energy of the LAT spectral component. We show synchrotron and inverse-Compton light-curves expected from pairs formed in the shocked medium and identify some criteria for testing a pair origin of GRB optical counterparts. Pairs formed in bright LAT afterglows with a Lorentz factor in the few hundreds may produce bright optical counterparts (R < 10) lasting for up to one hundred seconds. The number of internal pairs formed from unscattered seed photons decreases very strongly with the source Lorentz factor, thus bright GRB optical counterparts cannot arise from internal pairs if the afterglow Lorentz factor is above several hundreds.
description: 14 pages, to appear in the ApJ
Pollen Characteristics of Some Species in the Genus Bacopa
Creators: name: Yupadee Paopun
name: Piyanan Thanomchat
Publisher: name: The Microscopy Society of Thailand
Year: 2018
Subjects: Pollen, Bacopa, Scanning electron microscope

description: Microscopy and Microanalysis Research-The Journal of The Microscopy Society of Thailand, 31, 1, 24-28
Leaf Anatomy and Minimal Structure in Leaves of Hydrocotyle umbellata L., Obtained from Water Stress, were Examined under Electron Microscope and Light Microscope
Creators: name: Patcharee Umroong
Publisher: name: The Microscopy Society of Thailand
Year: 2018
Subjects: Anatomy
Ultrastructure
Hydrocotyle umbellata L
Transmission electron microscope
Light microscope

description: Microscopy and Microanalysis Research-The Journal of The Microscopy Society of Thailand, 31, 1, 29-33
Clinical Evidence Supports a Protective Role for CXCL5 in Coronary Artery Disease
Creators: name: Dai, X.
name: Patterson, C.
name: Stouffer, G.A.
name: Lee, C.R.
name: Schisler, J.C.
name: Willis, M.S.
name: Lenhart, K.
name: Hilliard, E.
name: Jensen, B.C.
name: Ravi, S.
name: Schuck, R.N.
Publisher: name: Elsevier Inc.
Year: 2017

description: Our goal was to measure the association of CXCL5 and molecular phenotypes associated with coronary atherosclerosis severity in patients at least 65 years old. CXCL5 is classically defined as a proinflammatory chemokine, but its role in chronic inflammatory diseases, such as coronary atherosclerosis, is not well defined. We enrolled individuals who were at least 65 years old and undergoing diagnostic cardiac catheterization. Coronary artery disease (CAD) severity was quantified in each subject via coronary angiography by calculating a CAD score. Circulating CXCL5 levels were measured from plasma, and both DNA genotyping and mRNA expression levels in peripheral blood mononuclear cells were quantified via microarray gene chips. We observed a negative association of CXCL5 levels with CAD at an odds ratio (OR) of 0.46 (95% CI, 0.27–0.75). Controlling for covariates, including sex, statin use, hypertension, hyperlipidemia, obesity, self-reported race, smoking, and diabetes, the OR was not significantly affected [OR, 0.54 (95% CI, 0.31–0.96)], consistent with a protective role for CXCL5 in coronary atherosclerosis. We also identified 18 genomic regions with expression quantitative trait loci of genes correlated with both CAD severity and circulating CXCL5 levels. Our clinical findings are consistent with the emerging link between chemokines and atherosclerosis and suggest new therapeutic targets for CAD.
(101547) George Partridge
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Global gene expression profiling of a mouse model of ovarian clear cell carcinoma caused by ARID1A and PIK3CA mutations implicates a role for inflammatory cytokine signaling
Creators: name: Magnuson, T.
name: Schisler, J.C.
name: Vernon, M.
name: Chandler, R.L.
name: Raab, J.R.
Publisher: name: Elsevier Inc
Year: 2015

description: Ovarian clear-cell carcinoma (OCCC) is an aggressive form of epithelial ovarian cancer (EOC). OCCC represents 5-25% of all EOC incidences and is the second leading cause of death from ovarian cancer (Glasspool and McNeish, 2013) [1]. A recent publication by Chandler et al. reported the first mouse model of OCCC that resembles human OCCC both genetically and histologically by inducing a localized deletion of ARID1A and the expression of the PIK3CAH1047R substitution mutation (Chandler et al., 2015) [2]. We utilized Affymetrix Mouse Gene 2.1 ST arrays for the global gene expression profiling of mouse primary OCCC tumor samples and animal-matched normal ovaries to identify cancer-dependent gene expression. We describe the approach used to generate the differentially expressed genes from the publicly available data deposited at the Gene Expression Omnibus (GEO) database under the accession number GSE57380. These data were used in cross-species comparisons to publically available human OCCC gene expression data and allowed the identification of coordinately regulated genes in both mouse and human OCCC and supportive of a role for inflammatory cytokine signaling in OCCC pathogenesis (Chandler et al., 2015) [2].
Silicon ring resonator based wavelength conversion via FWM at 10 Gb/s for differential phase-shift keyed signals
Creators: name: Li, F.
name: Pelusi, M.
name: Xu, D-X.
name: Ma, R.
name: Janz, S.
name: Eggleton, B. J.
name: Moss, D. J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We demonstrate all-optical wavelength conversion at 10 Gb/s for differential phase-shift keyed (DPSK) data signals in the C-band, based on four-wave mixing (FWM) in a silicon ring resonator. Error-free operation with a system penalty of ~ 4.1 dB at 10-9 BER is achieved.
description: 7 pages, 5 figures, 35 references
Preparation of Suitable Ultrathin Formvar Film for Transmission Electron Microscopic Technique
Creators: name: Piyanan Thanomchat
name: Yupadee Paopun
Publisher: name: The Microscopy Society of Thailand
Year: 2018
Subjects: Formvar film
Transmission electron microscopy
Characteristic

description: Microscopy and Microanalysis Research-The Journal of The Microscopy Society of Thailand, 31, 1, 34-38
title: Pott´s disease - Tuberculosis is back!
Creators: name: Nagrani Chellaram, Satish
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Neuroradiology spine
subject: Musculoskeletal spine
subject: MR
subject: CT
subject: Education
subject: Infection

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To review spinal tuberculosis pathogenesis and the correlation with imaging findings To illustrate MRI features in the spectrum of this...
title: Prospective Clinical Study of the reliability of CT Angiography (CTA) compared with Digital Angiography (DSA) in the diagnosis of brain death. Preliminary results
Creators: name: Dimoulia , Sofia
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: CNS
subject: CT-Angiography
subject: Diagnostic procedure
subject: Contrast agent-intravenous
subject: Haemodynamics / Flow dynamics

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Introduction Brain death (BD) is the irreversible injury of the brain, with loss of all functions of the brain stem. Patients with BD represent potential organ donors. Rapid confirmation is important in order to take the organs of the donor for...
title: Non-traumatic Pediatric Acute Abdomen in Indian Population : A Retrospective analysis
Creators: name: SHIRODKAR, KAPIL K
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Abdomen
subject: Emergency
subject: Paediatric
subject: Ultrasound
subject: Fluoroscopy
subject: CT
subject: Barium meal
subject: Acute

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Acute abdomen in children is one of the most common encountered pediatric emergency. The pediatric acute abdomen poses additional diagnostic challenge as infants and young children are unable to localize the exact site of pain and unable to provide...
mTORtuous effect on the elastic heart
Creators: name: Coleman, R.A.
name: Schisler, J.C.
Publisher: name: Impact Journals LLC
Year: 2015

description: Both during normal physiological development as well as in the face of cardiac stress, the heart exhibits enormous plasticity in growth, remodeling, and atrophy. Central to this adaptive ability is the heart’s metabolic capacity to react quickly both anabolically and catabolically in order to maintain cardiac output. In response to hemodynamic stress, the heart adapts to maintain overall contractile function via pathological remodeling that often includes cardiomyocyte hypertrophy as well as changes in cardiomyocyte metabolism that eventually lead to contractile dysfunction and heart failure. It is unclear as to whether the metabolic changes that accompany pathological hypertrophy are adaptive or maladaptive; however, as in most complex biological systems, the answer likely resides somewhere in the middle. Goodwin et al. demonstrated in 1998 that hemodynamic stress increases carbohydrate use for ATP generation and induces cardiac remodeling. Numerous subsequent studies have attributed the change in metabolism and cardiac remodeling to activation of the mammalian (or mechanistic) target of rapamycin (mTOR), a kinase that is a primary regulator of myocardial protein synthesis. Recent experimental models that manipulate cardiac metabolism and mTOR signaling have provided new insights into the relationship between metabolic and structural remodeling (reviewed in detail by Kundu et al.). One hopes that such models will identify metabolic changes that precede remodeling in order to find therapeutic targets for cardiac disease.
(101549) Emily Ann Partridge
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
New startup it's issue and challenges
Creators: name: Hansda, Dr.sushila susaren
name: Driessen, J.
name: Draga, Lisa
Publisher: name: figshare
Year: 2022
Subjects: subject: 150304 Entrepreneurship
subject: FOS: Economics and business

description: The Indian government in 2016 began an initiative called – Startup India to help create an enabling environment for entrepreneurs. Startup India provides support in three areas: it provides subsidies and assistance financially, it reduces regulatory burden, and it helps provide an environment for industry-academic partnerships by establishing bootcamps and innovation labs. However, the funds of Startup India have been invested in less than 1% of all Indian startups, meaning most of them still depend on private funding. Additionally, the distribution and funding for these startups are highly concentrated in large urban cities with few options for those in rural areas. There is a disparity of investments among different sectors as well, with IT-enabled technology sectors attracting most of the funding. The success of the entire ecosystem depends on the diversification of investments into sectors like agriculture, healthcare, education, and social services.This paper discusses few issues and challenges that an Indian startup has to face and the opportunities that the country can provide in the current ecosystem.
Extension of the Lieb-Schupp theorem to the Heisenberg models with higher order interactions
Creators: name: Tanaka, Kengo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We extend the Lieb-Schupp theorem to the Heisenberg models with higher order interactions on non-frustrated or frustrated finite lattices. These lattices are constructed by even numbered rings with or without crossing bonds and have reflection symmetry. The results show that all ground states have total spin zero in wide interaction parameters region which is not covered with the results of the Marshall-Lieb-Mattis type arguments.
description: Version 2, some changes were made
Scalarly charged particles and interparticle interaction with the Higgs potential
Creators: name: Ignat'ev, Yu. G.
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Asymptotically exact solutions are obtained for a spherically symmetric field with the Higgs potential generated by a point scalar charge, and a method for numerical integration of the equation for a scalar field with the Higgs potential of a point charge is proposed. Examples of numerical modeling of the equation of the scalar field of a single charge are given. With the help of the solution obtained, solutions of the relativistic equations of motion of a scalar charge in an external scalar field of the Higgs type of a singular scalar source are found and some unique properties of the interparticle scalar interaction are revealed.
description: 8 pages, 7 figures, 10 referenses
An_Inclusive_Education.pdf
Creators: name: Wilsher, Mark
name: Wilsher, Mark
Publisher: name: National Teaching Repository
Year: 2023
Subjects: classificationCode: 360602
subject: Fine arts
classificationCode: 360699
subject: Visual arts not elsewhere classified
classificationCode: 360601
subject: Crafts
classificationCode: 360603
subject: Performance art
classificationCode: 360604
subject: Photography, video and lens-based practice

description: A set of interviews with staff at Norwich University of the Arts describing steps they have taken to introduce reasonable adjustments within creative arts education, with the aim of supporting students who have particular access needs.
 This document is aimed at showing how easy it can be to make changes that have an impact for our students.
Emerging evidence of coding mutations in the ubiquitin-proteasome system associated with cerebellar ataxias
Creators: name: Ronnebaum, S.M.
name: Patterson, C.
name: Schisler, J.C.
Publisher: name: Nature Publishing Group
Year: 2014

description: Cerebellar ataxia (CA) is a disorder associated with impairments in balance, coordination, and gait caused by degeneration of the cerebellum. The mutations associated with CA affect functionally diverse genes; furthermore, the underlying genetic basis of a given CA is unknown in many patients. Exome sequencing has emerged as a cost-effective technology to discover novel genetic mutations, including autosomal recessive CA (ARCA). Five recent studies that describe how exome sequencing performed on a diverse pool of ARCA patients revealed 14 unique mutations in STUB1, a gene that encodes carboxy terminus of Hsp70-interacting protein (CHIP). CHIP mediates protein quality control through chaperone and ubiquitin ligase activities and is implicated in alleviating proteotoxicity in several neurodegenerative diseases. However, these recent studies linking STUB1 mutations to various forms of ataxia are the first indications that CHIP is directly involved in the progression of a human disease. Similar exome-sequencing studies have revealed novel mutations in ubiquitin-related proteins associated with CA and other neurological disorders. This review provides an overview of CA, describes the benefits and limitations of exome sequencing, outlines newly discovered STUB1 mutations, and theorizes on how CHIP and other ubiquitin-related proteins function to prevent neurological deterioration.
Nature of the many-body excitations in a quantum wire: theory and experiment
Creators: name: Tsyplyatyev, O.
name: Schofield, A. J.
name: Jin, Y.
name: Moreno, M.
name: Tan, W. K.
name: Anirban, A. S.
name: Ford, C. J. B.
name: Griffiths, J. P.
name: Farrer, I.
name: Jones, G. A. C.
name: Ritchie, D. A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The natural excitations of an interacting one-dimensional system at low energy are hydrodynamic modes of Luttinger liquid, protected by the Lorentz invariance of the linear dispersion. We show that beyond low energies, where quadratic dispersion reduces the symmetry to Galilean, the main character of the many-body excitations changes into a hierarchy: calculations of dynamic correlation functions for fermions (without spin) show that the spectral weights of the excitations are proportional to powers of $\mathcal{R}^{2}/L^{2}$, where $\mathcal{R}$ is a length-scale related to interactions and $L$ is the system length. Thus only small numbers of excitations carry the principal spectral power in representative regions on the energy-momentum planes. We have analysed the spectral function in detail and have shown that the first-level (strongest) excitations form a mode with parabolic dispersion, like that of a renormalised single particle. The second-level excitations produce a singular power-law line shape to the first-level mode and multiple power-laws at the spectral edge. We have illustrated crossover to Luttinger liquid at low energy by calculating the local density of state through all energy scales: from linear to non-linear, and to above the chemical potential energies. In order to test this model, we have carried out experiments to measure momentum-resolved tunnelling of electrons (fermions with spin) from/to a wire formed within a GaAs heterostructure. We observe well-resolved spin-charge separation at low energy with appreciable interaction strength and only a parabolic dispersion of the first-level mode at higher energies. We find structure resembling the second-level excitations, which dies away rapidly at high momentum in line with the theoretical predictions here.
description: 23 pages, 10 figures, 2 tables
title: Differential diagnosis between cerebral toxoplasmosis and primary CNS lymphoma (PCNSL) in patients with HIV/AIDS.
Creators: name: Dugova, Mariya
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: CNS
subject: Neuroradiology brain
subject: Oncology
subject: MR
subject: Education
subject: Treatment effects
subject: Imaging sequences
subject: AIDS
subject: Lymphoma
subject: Infection

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Human immunodeficiency virus (HIV)-associated central nervous system (CNS) lymphoma is a diffuse, large-cell non-Hodgkin lymphoma of B-cell origin that usually occurs in the brain (rarely in the spinal cord). It is a late complication of HIV...
The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells
Creators: name: Weir, G.C.
name: Lu, D.
name: Newgard, C.B.
name: Mirmira, R.G.
name: Taylor, D.G.
name: Takekawa, S.
name: Becker, T.C.
name: Jensen, P.B.
name: Schisler, J.C.
name: Knop, F.K.
name: German, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: We have previously described rat insulinoma INS-1 derived cell lines with robust or poor glucose-stimulated insulin secretion (GSIS). In the current study, we have further resolved these lines into three classes: class 1, glucose-unresponsive glucagon-expressing; class 2, glucose-unresponsive glucagon-negative; and class 3, glucose-responsive glucagon-negative. The transcription factor Nkx2.2 was expressed with relative abundance of 3.3, 1.0, and 1.0 in class 1, class 2, and class 3 cells, respectively, whereas Nkx6.1 expression had the opposite trend: 1.0, 2.6, and 6.4 in class 1, class 2, and class 3 cells, respectively. In class 1 cells, overexpressed Nkx6.1 suppressed glucagon expression but did not affect the levels of several other prominent beta cell transcription factors. RNA interference (RNAi)-mediated suppression of Nkx6.1 in class 3 cells resulted in a doubling of glucagon mRNA, with no effect on Pdx1 levels, whereas suppression of Pdx1 in class 3 cells caused a 12-fold increase in glucagon transcript levels, demonstrating independent effects of Nkx6.1 and Pdx1 on glucagon expression in beta cell lines. RNAi-mediated suppression of Nkx6.1 expression in class 3 cells also caused a decrease in GSIS from 13.9- to 3.7-fold, whereas suppression of Pdx1 reduced absolute amounts of insulin secretion without affecting fold response. Finally, RNAi-mediated suppression of Nkx6.1 mRNA in primary rat islets was accompanied by a significant decrease in GSIS relative to control cells. In sum, our studies have revealed roles for Nkx6.1 in suppression of glucagon expression and control of GSIS in islet beta cells.
title: Spectrum of Congenital Heart Diseases on Computed Tomography : Pictorial essay
Creators: name: Agarwal, Deepak
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Cardiac
subject: CT-Angiography
subject: Diagnostic procedure
subject: Congenital

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: • To pictorially review the Computed Tomography findings in Congenital Heart Diseases • To emphasize the role of Multidetector Computed Tomography in Congenital heart...
Keck Near-Infrared Detections of Mab and Perdita
Creators: name: Molter, Edward M.
name: de Pater, Imke
name: Moeckel, Chris
Publisher: name: arXiv
Year: 2023
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We report the first near-infrared detection of Uranus's tiny moon Mab, the presumed source of the blue and diffuse $μ$ ring, using the NIRC2 instrument at Keck Observatory. The detection was permitted by an updated shift-and-stack procedure allowing us to integrate on Mab as it moved across the detector in 23 separate exposures taken over $\sim$2 hours, as well as the very low (0.02$^{\circ}$) phase angle at the time of observation. At this phase angle, Mab has an integrated I/F of 24 $\pm$ 3 km$^2$ at 1.6 $μ$m and $\lesssim$37 km$^2$ at 2.1 $μ$m. Comparing these values with Mab's visible reflectance as derived by HST reveals that Mab is spectrally blue; its (0.5 $μ$m)/(1.6 $μ$m) color is more consistent with Miranda's value than Puck's value. Mab is therefore more likely a $\sim$6-km radius body with a Miranda-like surface than a 12-km radius body with a Puck-like surface, in agreement with prior work based on infrared upper limits, but we caution that a Puck-like color is only ruled out at the 2$σ$ level. We also report the first infrared photometry of Perdita, finding an integrated I/F of 31 $\pm$ 3 km$^2$ at 1.6 $μ$m.
description: 13 pages, 5 figures, published in Icarus Letters
Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: Application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes
Creators: name: Mirmira, R.G.
name: Schisler, J.C.
name: Garmey, J.C.
name: Newgard, C.B.
name: Iype, T.
name: Nesher, R.
name: Becker, T.C.
name: Francis, J.
name: Griffen, S.C.
name: Weir, G.C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: The homeodomain factor Pdx-1 regulates an array of genes in the developing and mature pancreas, but whether regulation of each specific gene occurs by a direct mechanism (binding to promoter elements and activating basal transcriptional machinery) or an indirect mechanism (via regulation of other genes) is unknown. To determine the mechanism underlying regulation of the insulin gene by Pdx-1, we performed a kinetic analysis of insulin transcription following adenovirus-mediated delivery of a small interfering RNA specific for pdx-1 into insulinoma cells and pancreatic islets to diminish endogenous Pdx-1 protein, insulin transcription was assessed by measuring both a long half-life insulin mRNA (mature mRNA) and a short half-life insulin pre-mRNA species by real-time reverse transcriptase-PCR. Following progressive knock-down of Pdx-1 levels, we observed coordinate decreases in pre-mRNA levels (to about 40% of normal levels at 72 h). In contrast, mature mRNA levels showed strikingly smaller and delayed declines, suggesting that the longer half-life of this species underestimates the contribution of Pdx-1 to insulin transcription. Chromatin immunoprecipitation assays revealed that the decrease in insulin transcription was associated with decreases in the occupancies of Pdx-1 and p300 at the proximal insulin promoter. Although there was no corresponding change in the recruitment of RNA polymerase II to the proximal promoter, its recruitment to the insulin coding region was significantly reduced. Our results suggest that Pdx-1 directly regulates insulin transcription through formation of a complex with transcriptional coactivators on the proximal insulin promoter. This complex leads to enhancement of elongation by the basal transcriptional machinery. © 2005 by The American Society for Biochemistry and Molecular Biology, Inc.
title: Temporomandibular joint anatomic features and pathologies – Pictorial essay
Creators: name: Tames, Hugo
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Head and neck
subject: Anatomy
subject: CT
subject: MR
subject: MR-Diffusion/Perfusion
subject: Diagnostic procedure
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To demonstrate and discuss temporomandibular joint (TMJ) anatomic features and main pathologies, reviewing the role of MR / CT imaging so that residents and radiologists can improve their standardized...
A Cluster Randomized Trial of a Community-Based Intervention Among African-American Adults: Effects on Dietary and Physical Activity Outcomes
Creators: name: Young, T.L.
name: Calancie, L.
name: Wynn, M.
name: Corbie-Smith, G.
name: Bess, K.
name: Cené, C.W.
name: McFarlin, S.
name: Frerichs, L.
name: Hoover, S.M.
name: Dave, G.
Publisher: name: Springer
Year: 2020

description: Evidence of the effectiveness of community-based lifestyle behavior change interventions among African-American adults is mixed. We implemented a behavioral lifestyle change intervention, Heart Matters, in two rural counties in North Carolina with African-American adults. Our aim was to evaluate the effect of Heart Matters on dietary and physical activity behaviors, self-efficacy, and social support. We used a cluster randomized controlled trial to compare Heart Matters to a delayed intervention control group after 6 months. A total of 143 African-American participants were recruited and 108 completed 6-month follow-up assessments (75.5%). We used mixed regression models to evaluate changes in outcomes from baseline to 6-month follow-up. The intervention had a significant positive effect on self-reported scores of encouragement of healthy eating, resulting in an increase in social support from family of 6.11 units (95% CI [1.99, 10.22]) (p <.01). However, intervention participants also had an increase in discouragement of healthy eating compared to controls of 5.59 units (95% CI [1.46, 9.73]) among family (p <.01). There were no significant differences in changes in dietary behaviors. Intervention participants had increased odds (OR = 2.86, 95% CI [1.18, 6.93]) of increased frequency of vigorous activity for at least 20 min per week compared to control participants (p <.05). Individual and group lifestyle behavior counseling can have a role in promoting physical activity levels among rural African-American adults, but more research is needed to identify the best strategies to bolster effectiveness and influence dietary change. Trial Registration Clinical Trials, NCT02707432. Registered 13 March 2016.
Финансово—экономический журнал,Выпуск 16 МНКАВ 2023
Creators: name: ООО "Институт развития образования и консалтинга"
Publisher: name: ООО "Институт развития образования и консалтинга"
Year: 2023

description: Финансово—экономический журнал,Выпуск 16 МНКАВ 2023
Recherche et veille documentaire en Histoire
Creators: name: Elsa, BRES
name: OUCHTAR, Nora
Publisher: name: Zenodo
Year: 2025
Subjects: recherche et veille documentaire
veille documentaire
histoire
doctorat

description: Objectifs : A l’issue de la formation, les apprenants sauront construire une stratégie de recherche d’information et de veille documentaire 

Ils auront compris comment acquérir l’information qui leur est nécessaire pour leur recherche par la mise en place de stratégie efficiente de recherche documentaire ou la mise en place d’une veille efficace.
Synapse: Synthetic Application Profiler and Emulator
Creators: name: Merzky, Andre
name: Jha, Shantenu
Publisher: name: arXiv
Year: 2015
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Computer and information sciences

description: We introduce Synapse motivated by the needs to estimate and emulate workload execution characteristics on high-performance and distributed heterogeneous resources. Synapse has a platform independent application profiler, and the ability to emulate profiled workloads on a variety of heterogeneous resources. Synapse is used as a proxy application (or "representative application") for real workloads, with the added advantage that it can be tuned at arbitrary levels of granularity in ways that are simply not possible using real applications. Experiments show that automated profiling using Synapse represents application characteristics with high fidelity. Emulation using Synapse can reproduce the application behavior in the original runtime environment, as well as reproducing properties when used in a different run-time environments.
title: An update and practical working guide to the imaging of Alzhemiers disease
Creators: name: Burd, Christian
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: CNS
subject: Neuroradiology brain
subject: CT
subject: MR
subject: Comparative studies
subject: Education
subject: Staging
subject: Dementia
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Knowledge of a standardised protocol for dementia imaging and systematic approach to interpretation. How to identify the key anatomical structures necessary in dementia imaging. Knowedge of the basic imaging findings in AD. Explanation of the visual...
Combating the Curse of Multilinguality in Cross-Lingual WSD by Aligning Sparse Contextualized Word Representations
Creators: name: Berend, Gábor
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computation and Language (cs.CL)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: In this paper, we advocate for using large pre-trained monolingual language models in cross lingual zero-shot word sense disambiguation (WSD) coupled with a contextualized mapping mechanism. We also report rigorous experiments that illustrate the effectiveness of employing sparse contextualized word representations obtained via a dictionary learning procedure. Our experimental results demonstrate that the above modifications yield a significant improvement of nearly 6.5 points of increase in the average F-score (from 62.0 to 68.5) over a collection of 17 typologically diverse set of target languages. We release our source code for replicating our experiments at https://github.com/begab/sparsity_makes_sense.
description: Presented at NAACL2022
Calidad de Vida: a systematic review of quality of life in Latino cancer survivors in the USA
Creators: name: Elkins, W.
name: Samuel, C.A.
name: Pinheiro, L.C.
name: Walker, J.S.
name: Mbah, O.M.
name: Szymeczek, M.A.
name: Padilla, N.
name: Corbie-Smith, G.
Publisher: name: Springer
Year: 2020

description: Background: Cancer is the leading cause of death among Hispanics/Latinos. Thus, understanding health-related quality of life (HRQOL) needs among this diverse racial/ethnic group is critical. Using Ferrell’s multidimensional framework for measuring QOL, we synthesized evidence on HRQOL needs among Hispanic/Latino cancer survivors. Methods: We searched MEDLINE/PubMed, EMBASE, CINAHL, and PsycINFO, for English language articles published between 1995 and January 2020, reporting HRQOL among Hispanic/Latino cancer survivors in the USA. Results: Of the 648 articles reviewed, 176 met inclusion criteria, with 100 of these studies focusing exclusively on breast cancer patients and no studies examining end-of-life HRQOL issues. Compared with other racial/ethnic groups, Hispanics/Latinos reported lower HRQOL and a higher symptom burden across multiple HRQOL domains. Over 80% of studies examining racial/ethnic differences in psychological well-being (n = 45) reported worse outcomes among Hispanics/Latinos compared with other racial/ethnic groups. Hispanic/Latino cancer survivors were also more likely to report suboptimal physical well-being in 60% of studies assessing racial/ethnic differences (n = 27), and Hispanics/Latinos also reported lower social well-being relative to non-Hispanics/Latinos in 78% of studies reporting these outcomes (n = 32). In contrast, reports of spiritual well-being and spirituality-based coping were higher among Hispanics/Latinos cancer survivors in 50% of studies examining racial/ethnic differences (n = 15). Discussion: Findings from this review point to the need for more systematic and tailored interventions to address HRQOL needs among this growing cancer survivor population. Future HRQOL research on Hispanics/Latinos should evaluate variations in HRQOL needs across cancer types and Hispanic/Latino subgroups and assess HRQOL needs during metastatic and end-of-life disease phases.
(101543) Ernest Parkman
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Trust in Community-Engaged Research Partnerships: A Methodological Overview of Designing a Multisite Clinical and Translational Science Awards (CTSA) Initiative
Creators: name: Vassar, S.
name: Thorpe, R.J., Jr
name: Black, A.
name: Cheney, A.
name: Cene, C.W.
name: Varma, D.
name: Dave, G.J.
name: Cottler, L.
name: Kim, M.M.
name: Ruktanonchai, C.
name: Burke, J.
name: Young, T.
name: Schaal, J.
name: Striley, C.
name: Frerichs, L.
name: Corbie-Smith, G.
name: Brown, A.
name: Sullivan, G.
name: Jones, J.
Publisher: name: SAGE Publications Inc.
Year: 2020

description: Community-engaged research (CEnR) builds on the strengths of the Clinical and Translational Science Awards (CTSA) framework to address health in underserved and minority communities. There is a paucity of studies that identify the process from which trust develops in CEnR partnerships. This study responds to the need for empirical investigation of building and maintaining trust from a multistakeholder perspective. We conducted a multi-institutional pilot study using concept mapping with to better understand how trust, a critical outcome of CEnR partnerships, can act as “social capital.” Concept mapping was used to collect data from the three stakeholder groups community, health-care, and academic research partners across three CTSAs. Concept mapping is a mixed-methods approach that allows participants to brainstorm and identify factors that contribute to a concept and describe ways in which those factors relate to each other. This study offers important insights on developing an initial set of trust measures that can be used across CTSAs to understand differences and similarities in conceptualization of trust among key stakeholder groups, track changes in public trust in research, identify both positive and negative aspects of trust, identify characteristics that maintain trust, and inform the direction for future research.
title: Illustrated Guide to the Role of Multidisciplinary Specialists in the Management of Endometriosis.
Creators: name: Anstee, Ann
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Genital / Reproductive system female
subject: Management
subject: MR
subject: Ultrasound
subject: Education
subject: Patterns of Care

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To provide illustrated cases of endometriosis to demonstrate the necessity of a multidisciplinary approach to management. To highightthe central role ofspecialist radiology provision in defining and delineating disease in endometriosis. To...
title: Colour shading in ultrasound imaging
Creators: name: Jimenez Galvez, Francisco
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Radiographers
subject: Ultrasound physics
subject: Abdomen
subject: Ultrasound
subject: Technical aspects
subject: Perception image
subject: Outcomes

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The effectiveness of ultrasound equipment is based on both its technical specifications and its user-modifiable parameters. Within the group of dependent variables are some of high importance for any sonographer; tools such as fundamental frequency...
(101540) Sarah Parkman
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Convergence despite divergence: Views of academic and community stakeholders about the ethics of community-engaged research
Creators: name: Wynn, M.
name: Kim, J.
name: Tiwari, S.
name: Richmond, A.
name: Rennie, S.
name: Green, M.
name: Hoover, S.M.
name: Nisbeth, K.S.
name: Corbie-Smith, G.
Publisher: name: Ethnicity and Disease, Inc.
Year: 2019

description: Purpose: Stakeholder engagement and community-engaged research (CEnR) are recognized as approaches necessary to promote health equity. Few studies have examined variations in stakeholder perspectives on research ethics despite the potential for meaningful differences. Our study examines the association between stakeholders' characteristics and their perception of the importance of 15 stakeholder-developed CEnR ethical statements. Design: Quantitative analysis of close-ended Delphi survey. Participants: We recruited a national, non-random, purposive sample of people who were eligible if they endorsed conducting CEnR in public health or biomedical fields. Participants were recruited from publicly available information, professional email distributions, and snowball sampling. Main Outcome Measures: We designed our close-ended Delphi survey from the results of 15 CEnR ethical statements, which were developed from a consensus development workshop with academic and community stakeholders. Results: 259 participants completed the Delphi survey. The results demonstrated that stakeholders' characteristics (affiliation, ethnicity, number of CEnR relationships, and duration of CEnR partnerships) were not associated with their perception of the importance of 15 ethical statements. Conclusions: The strong agreement among stakeholders on these broad, aspirational ethical statements can help guide partnerships toward ethical decisions and actions. Continued research about variability among stakeholders' ethics perspectives is needed to bolster the capacity of CEnR to contribute to health equity.
Existence and stability of periodic solutions of a Lotka-Volterra system
Creators: name: Linh, Nguyen Thi Hoai
name: Quang, Ta Hong
name: Ton, Ta Viet
Publisher: name: arXiv
Year: 2015
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics

description: In this paper, we study a Lotka-Volterra model which contains two prey and one predator with the Beddington-DeAngelis functional responses. First, we establish a set of sufficient conditions for existence of positive periodic solutions. Second, we investigate global asymptotic stability of boundary periodic solutions. Finally, we present some numerical examples.