title: ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¼ÐµÑÐ¾Ð´Ð¾Ð¼ ÐÐ ÑÐ¿ÐµÐºÑÑÐ¾ÑÐºÐ¾Ð¿Ð¸Ð¸ Ð¼Ð¾Ð´Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¸ ÐºÐ¾Ð»Ð»Ð°Ð³ÐµÐ½Ð° I ÑÐ¸Ð¿Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Investigation of type I collagen modification by IR spectroscopy
Creators: name: Ð¡ÑÐ°ÑÐ¾ÑÑÐ¸Ð½Ð°, ÐÐ³Ð°ÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: ÐºÐ¾Ð»Ð»Ð°Ð³ÐµÐ½
ÑÐ¸Ð±ÑÐ¸Ð»Ð»ÑÑÐ½Ð°Ñ ÑÑÑÑÐºÑÑÑÐ°
ÐÐ-Ð¤ÑÑÑÐµ ÑÐ¿ÐµÐºÑÑÐ¾ÑÐºÐ¾Ð¿Ð¸Ñ
Ð²Ð°Ð»ÐµÐ½ÑÐ½ÑÐµ ÐºÐ¾Ð»ÐµÐ±Ð°Ð½Ð¸Ñ
Ð´ÐµÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½ÑÐµ ÐºÐ¾Ð»ÐµÐ±Ð°Ð½Ð¸Ñ
collagen
fibrillar structure
fourier transform infrared spectroscopy (FTIR)
stretching vibrations
bending vibrations

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description: The aim of the work was to study the infrared Fourier spectroscopy (FTIR) of structural forms and chemical groups formed as a result of chemical modification of collagen. The samples consisted of dried solutions of molecular and fibrillar collagen type I deposited on metal substrates, processed with hydrogen peroxide, phytic acid or glutaraldehyde. The results of the work expand the possibilities for carrying out a controlled process of modifying the collagen fibrillar structure, which is an important step towards creating complex collagen structures for biology and regenerative medicine. The present study has focused on the possibility of using the method of infrared Fourier spectroscopy to identify collagen bonds in molecular and fibrillar forms. The IR spectra of collagen modified with various agents were obtained and specific differences between them were revealed. The values of the wavenumbers corresponding to the vibrations of the identified chemical groups characteristic of a particular modification of collagen are determined.The spectral features of pure type I collagen in molecular and fibrillar form are described in detail.