Additional file 1 of Comparison of gadolinium-based contrast agents for MR cholangiography in saline, blood and bile: a phantom study
Creators: name: Froehlich, Johannes M.
name: Moussa, Leen
name: Guirguis, Natalie
name: Gutzeit, Andreas
name: Wu, David
name: Sartoretti-Schefer, Sabine
name: Koh, Dow-Mu
name: Kolokythas, Orpheus
name: Matoori, Simon
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: Additional file 1: Supplementary Figure S1. Bile phantom set up. Ox bile and contrast agents were mixed in 2 mL polypropylenetubes (bile phantom, a) and placed in a sample holder b. Supplementary Figure S2. Signal intensities of gadoterate, gadobenate, and gadoxetate in saline and biological fluids on T1-weighted SE and TFE MRI. Signal intensities of gadoterate, gadobenate, and gadoxetate at different concentrations in saline (a), blood (b), and bile (c) on T1-weighted spin echo MRI. Signal intensities ofgadoterate, gadobenate, and gadoxetate at different concentrations in saline (d), blood (e), and bile (f) on T1-weighted turbo field echo MRI. *: significantly higher maximum signal intensity of the contrast agent than both other contrast agents; +: significantly higher maximum signal intensity than the contrast agent with the lowest maximum signal intensity. * or +: p &lt; 0.05,** or ++: p &lt; 0.01; *** or +++: p &lt; 0.001. The data are extracted from Figure 2. Supplementary Figure S3. Signal intensities of gadoterate, gadobenate, and gadoxetate in saline and biological fluids on 3D-mFFE and mGraSE MRI. Signal intensities of gadoterate, gadobenate, and gadoxetate at different concentrations in saline (a), blood (b), and bile (c) on 3D-mFFE MRI. Signal intensities of gadoterate, gadobenate, and gadoxetate at different concentrations in saline (d), blood (e), and bile (f) on mGraSE MRI. The data are extracted from Figure 3. Supplementary Figure S4. Signal intensities of gadoterate, gadobenate, and gadoxetate in saline and biological fluids on STIR and eTHRIVE MRI. Signal intensities of gadoterate, gadobenate, and gadoxetate at different concentrations in saline (a), blood (b), and bile (c) on STIR MRI. Signal intensities of gadoterate, gadobenate, and gadoxetateat different concentrations in saline (d), blood (e), and bile (f) on E-THRIVE MRI. The data are extracted from Figure 4. Supplementary Figure S5. Signal intensities of gadoterate, gadobenate, and gadoxetate in saline and biological fluids on T2-weighted TSE and FLAIR MRI. Signal intensities of gadoterate, gadobenate, and gadoxetate at different concentrations in saline (a), blood (b), and bile (c) on T2-weighted TSE MRI. Signal intensities of gadoterate, gadobenate, and gadoxetate at different concentrations in saline (d), blood (e), and bile (f) on FLAIR MRI. The data are extracted from Figure 6. Supplementary Table S1. Summary table of main results in the comparisons of maximum signal intensities of contrast agents.