cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Framing the third cycling century
Creators: name: Bunte, Heike
name: Grafl, Katherina
name: Dziekan, Katrin
Publisher: name: My University
Year: 2018
Subjects: subject: Radfahren
subject: Fahrradmobilität
subject: Nachhaltige Mobilität
subject: cycling
subject: bicycle mobility
subject: sustainable mobility
subject: active mobility
subject: International Cycling Conference
subject: Verkehr
subject: Transport

description: There is a tension between research and practice in the field of cycling as well as in general in environmental policy. Numerous scientific publications and knowledge do not reach the practitioners who might benefit from them. Not only was the International Cycling Conference 2017 intended to tackle this deficit with a large-scale forum, but also this publication, which takes up and continues the discussion started there. The innovative concept of the triad, consisting of scientists, practitioners and experts, produces new perspectives. The authors come from all over the world, forming together an international mosaic that incorporates their particular perceptions and experiences.
The lived experiences of middle managers in adapting global influences: a case study
Creators: name: Goodman, Clare Louise
Publisher: name: Swinburne
Year: 2024

description: This study delves into how middle managers adapt to global influences such as strategies and policies through the relationship between sensemaking and adapting. It uncovers a dual sensemaking process affecting both sense and action, prompting a reassessment of senior leaders' approach to implementing global strategies. Additionally, it sheds light on middle managers overlooked adaptive capability in co-creating these global influences.
title: Samples and data accessibility in research biobanks
title: an explorative survey
titleType: Subtitle
Creators: name: Capocasa, Marco
name: Anagnostou, Paolo
name: D'Abramo, Flavio
name: Matteucci, Giulia
name: Dominici, Valentina
name: Bisol, Giovanni Destro
name: Rufo, Fabrizio
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: Open science
subject: Data sharing
subject: Research ethics
subject: Human subjects
subject: Biorepository
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Biobanks, which contain human biological samples and/or data, provide a crucial contribution to the progress of biomedical research. However, the effective and efficient use of biobank resources depends on their accessibility. In fact, making bio-resources promptly accessible to everybody may increase the benefits for society. Furthermore, optimizing their use and ensuring their quality will promote scientific creativity and, in general, contribute to the progress of bio-medical research. Although this has become a rather common belief, several laboratories are still secretive and continue to withhold samples and data. In this study, we conducted a questionnaire-based survey in order to investigate sample and data accessibility in research biobanks operating all over the world. The survey involved a total of 46 biobanks. Most of them gave permission to access their samples (95.7%) and data (85.4%), but free and unconditioned accessibility seemed not to be common practice. The analysis of the guidelines regarding the accessibility to resources of the biobanks that responded to the survey highlights three issues: (i) the request for applicants to explain what they would like to do with the resources requested; (ii) the role of funding, public or private, in the establishment of fruitful collaborations between biobanks and research labs; (iii) the request of co-authorship in order to give access to their data. These results suggest that economic and academic aspects are involved in determining the extent of sample and data sharing stored in biobanks. As a second step of this study, we investigated the reasons behind the high diversity of requirements to access biobank resources. The analysis of informative answers suggested that the different modalities of resource accessibility seem to be largely influenced by both social context and legislation of the countries where the biobanks operate.
Varied Genomic Responses to Maladaptive Gene Flow and Their Evidence
Creators: name: Roesti, Marius
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Adaptation to a local environment often occurs in the face of maladaptive gene flow. In this perspective, I discuss several ideas on how a genome may respond to maladaptive gene flow during adaptation. On the one hand, selection can build clusters of locally adaptive alleles at fortuitously co-localized loci within a genome, thereby facilitating local adaptation with gene flow (‘allele-only clustering’). On the other hand, the selective pressure to link adaptive alleles may drive co-localization of the actual loci relevant for local adaptation within a genome through structural genome changes or an evolving intra-genomic crossover rate (‘locus clustering’). While the expected outcome is, in both cases, a higher frequency of locally adaptive alleles in some genome regions than others, the molecular units evolving in response to gene flow differ (i.e., alleles versus loci). I argue that, although making this distinction is important, we commonly lack the critical empirical evidence to do so. This is mainly because many current approaches are biased towards detecting local adaptation in genome regions with low crossover rates. The importance of low-crossover genome regions for adaptation with gene flow, such as in co-localizing relevant loci within a genome, thus remains unclear. Future empirical investigations should address these questions by making use of comparative genomics, where multiple de novo genome assemblies from species evolved under different degrees of genetic exchange are compared. This research promises to advance our understanding of how a genome adapts to maladaptive gene flow, thereby promoting adaptive divergence and reproductive isolation.
The 2dF galaxy redshift survey: Correlation with the ROSAT-ESO flux-limited X-ray galaxy cluster survey
Creators: name: Hilton, Matt
name: Collins, Chris
name: De Propris, Roberto
name: Baldry, Ivan K.
name: Baugh, Carlton M.
name: Bland-Hawthorn, Joss
name: Bridges, Terry
name: Cannon, Russell
name: Cole, Shaun
name: Colless, Matthew
name: Couch, Warrick
name: Dalton, Gavin B.
name: Driver, Simon P.
name: Efstathiou, George
name: Ellis, Richard S.
name: Frenk, Carlos S.
name: Glazebrook, Karl
name: Jackson, Carole A.
name: Lahav, Ofer
name: Lewis, Ian
name: Lumsden, Stuart
name: Maddox, Steve J.
name: Madgwick, Darren
name: Norberg, Peder
name: Peacock, John A.
name: Peterson, Bruce A.
name: Sutherland, Will
name: Taylor, Keith
Publisher: name: Swinburne
Year: 2024

description: The ROSAT-European Southern Observatory (ESO) flux-limited X-ray (REFLEX) galaxy cluster survey and the Two-degree Field Galaxy Redshift Survey (2dFGRS), respectively, comprise the largest, homogeneous X-ray selected cluster catalogue and completed galaxy redshift survey. In this work, we combine these two outstanding data sets in order to study the effect of the large-scale cluster environment, as traced by X-ray luminosity, on the properties of the cluster member galaxies. We measure the LX−σr relation from the correlated data set and find it to be consistent with recent results found in the literature. Using a sample of 19 clusters with LX≥ 0.36 × 1044 erg s−1 in the 0.1–2.4 keV band, and 49 clusters with lower X-ray luminosity, we find that the fraction of early spectral type (η≤−1.4) , passively evolving galaxies is significantly higher in the high-LX sample within R200. We extend the investigation to include composite bJ cluster luminosity functions, and find that the characteristic magnitude of the Schechter-function fit to the early-type luminosity function is fainter for the high-LX sample compared to the low-LX sample (ΔM*= 0.58 ± 0.14) . This seems to be driven by a deficit of such galaxies with MbJ∼−21. In contrast, we find no significant differences between the luminosity functions of star-forming, late-type galaxies. We believe these results are consistent with a scenario in which the high-LX clusters are more dynamically evolved systems than the low-LX clusters.
title: Bupropion for the treatment of apathy in Huntington’s disease
title: A multicenter, randomised, double-blind, placebo-controlled, prospective crossover trial
titleType: Subtitle
Creators: name: Gelderblom, Harald
name: Wuestenberg, Torsten
name: McLean, Tim
name: Muetze, Lisanne
name: Fischer, Wilhelm
name: Saft, Carsten
name: Hoffmann, Rainer
name: Priller, Josef [U.A.]
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Objective To evaluate the efficacy and safety of bupropion in the treatment of apathy in Huntington’s disease (HD). Methods In this phase 2b multicentre, double-blind, placebo-controlled crossover trial, individuals with HD and clinical signs of apathy according to the Structured Clinical Interview for Apathy—Dementia (SCIA-D), but not depression (n = 40) were randomized to receive either bupropion 150/300mg or placebo daily for 10 weeks. The primary outcome parameter was a significant change of the Apathy Evaluation Scale (AES) score after ten weeks of treatment as judged by an informant (AES-I) living in close proximity with the study participant. The secondary outcome parameters included changes of 1. AES scores determined by the patient (AES-S) or the clinical investigator (AES-C), 2. psychiatric symptoms (NPI, HADS-SIS, UHDRS-Behavior), 3. cognitive performance (SDMT, Stroop, VFT, MMSE), 4. motor symptoms (UHDRS-Motor), 5. activities of daily function (TFC, UHDRS-Function), and 6. caregiver distress (NPI-D). In addition, we investigated the effect of bupropion on brain structure as well as brain responses and functional connectivity during reward processing in a gambling task using magnetic resonance imaging (MRI). Results At baseline, there were no significant treatment group differences in the clinical primary and secondary outcome parameters. At endpoint, there was no statistically significant difference between treatment groups for all clinical primary and secondary outcome variables. Study participation, irrespective of the intervention, lessened symptoms of apathy according to the informant and the clinical investigator. Conclusion Bupropion does not alleviate apathy in HD. However, study participation/placebo effects were observed, which document the need for carefully controlled trials when investigating therapeutic interventions for the neuropsychiatric symptoms of HD. Trial registration ClinicalTrials.gov 01914965
Optimization of PEGylation for cationic triacyl lipid-based siRNA lipoplexes prepared using the modified ethanol injection method for tumor therapy
Creators: name: Hattori, Yoshiyuki
name: Shinkawa, Mizuki
name: Kurihara, Aya
name: Shimizu, Ryohei
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology

description: We previously developed a modified ethanol injection (MEI) method to construct small interfering RNA (siRNA) lipoplexes by mixing a lipid–ethanol solution with an siRNA-containing phosphate-buffered saline solution. Here, we constructed siRNA lipoplexes with 11-((1,3-bis(dodecanoyloxy)-2-((dodecanoyloxy)methyl)propan-2-yl)amino)-N,N,N-trimethyl-11-oxoundecan-1-aminium bromide (TC-1-12), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, and poly(ethylene glycol) (PEG)–lipid using our MEI method. The siRNA lipoplexes were PEGylated with 1, 3, 5, and 10 mol% PEG cholesteryl ether (PEG–Chol), 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol (mPEG–DMG), or 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(methoxy[polyethylene glycol]) (mPEG–DSPE). PEGylation of siRNA lipoplexes with PEG–Chol did not attenuate the inhibitory effects of Luc and polo-like kinase 1 (PLK1) siRNA lipoplexes on the luciferase (Luc) activity and proliferation of human cervical carcinoma HeLa-Luc, human ovarian cancer SK-OV-3-Luc, and human breast cancer MCF-7-Luc cells stably expressing Luc. In contrast, PEGylated lipoplexes with 10 mol% mPEG–DMG inhibited Luc activity by Luc siRNA but considerably attenuated the PLK1 siRNA-mediated cytotoxic effects. For PEGylated siRNA lipoplexes with mPEG–DSPE, inhibitory effect of Luc siRNA on Luc activity decreased with increasing amounts of PEG modification, and PLK1 siRNA-mediated cytotoxic effects disappeared at more than 3 mol% PEGylation. Erythrocyte aggregation and hemolysis induction by the siRNA lipoplexes were effectively inhibited by 10 mol% PEGylation, irrespective of the PEG–lipid. Compared to those with 1 mol% PEG–Chol, PEGylated siRNA lipoplexes with 10 mol% PEG–Chol potently reduced siRNA accumulation in mouse lungs post-intravenous administration. Overall, TC-1-12-based siRNA lipoplexes with 10 mol% PEG–Chol exerted PLK1 siRNA-mediated cytotoxic effects, without inducing hemolysis and erythrocyte aggregation.
"African barbarism" and "Anglo-Saxon civilization": The mythic foundations of school segregation and African-Canadian resistance in Canada West
Creators: name: McLaren, Kristin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Religion, General.
subject: History, Black.
subject: History, Canadian.
subject: Education, History of.

description: The legend of the Underground Railroad and the ideal of Canada as a promised land for African-American fugitive slaves have been pervasive in the Canadian imagination. In the mid-nineteenth century, myths describing British Canada West as a moral exemplar and guarantor of equal rights to all provided a sense of transcendent meaning and orientation to citizens of British and African heritage. British-Canadian school promoters hoped to lay the foundations of an ideal British society in the emerging public school system. The main proponent of this system, Egerton Ryerson, boasted of the merits of a Christian and moral education provided to all Canadians without discrimination. However, African Canadians were largely excluded from public education in Canada West, or forced into segregation, a practice that was against the spirit of egalitarian British laws. British-Canadian mythologies that called for the protection of Anglo-Saxon racial purity allowed for the introduction of this practice of school segregation. In response, many African-Canadian leaders called upon Canadian society to live up to its egalitarian ideals and promoted integration. This work examines dominant discourses that presented the British-Canadian people as a culturally pure group, unchanged by their historical environment, and contrasts these mythologies with African-Canadian mythologies that reflected the culturally diverse nature of Canadian society and emphasized the potential for human transformation in mid-nineteenth century Canada West.
title: Aquatic suspended particulate matter as source of eDNA for fish metabarcoding
title: Aquatic suspended particulate matter as source of eDNA for fish metabarcoding
titleType: AlternativeTitle
Creators: name: Díaz, Cecilia
name: Koschorreck, Jan
name: Wege, Franziska-Frederike
name: Tang, Cuong Q.
Publisher: name: My University
Year: 2020

description: The use of environmental DNA (eDNA) for monitoring aquatic macrofauna allows the non-invasive species determination and measurement of their DNA abundance and typically involves the analysis of eDNA captured from water samples. In this proof-of-concept study, we focused on the novel use of eDNA extracted from archived suspended particulate matter (SPM) for identifying fish species using metabarcoding, which benefits from the prospect of retrospective monitoring and also analysis of fish communities through time. We used archived SPM samples of the German Environmental Specimen Bank (ESB), which were collected using sedimentation traps from different riverine points in Germany. Environmental DNA was extracted from nine SPM samples differing in location, organic content, and porosity (among other factors) using four different methods for the isolation of high-quality DNA. Application of the PowerSoil DNA Isolation Kit with an overnight incubation in lysis buffer, resulted in DNA extraction with the highest purity and eDNA metabarcoding of these eDNA fragments was used to detect a total of 29 fish taxa among the analyzed samples. Here we demonstrated for the first time that SPM is a promising source of eDNA for metabarcoding analysis, which could provide valuable retrospective information (when using archived SPM) for fish monitoring, complementing the currently used approaches. © 2020 Springer Nature Limited
Experimental and theoretical studies of ion-molecule complexes and of some ionized diketones in the gas-phase
Creators: name: Wang, Xian
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Chemistry, General.

description: This thesis describes some research in gas-phase ion chemistry, using mass spectrometry techniques combined with theoretical calculations. Metastable ion and collision-induced dissociation mass spectra, kinetic energy release and isotopic labelling were used to characterize and identify precursor and fragment ions and to predict reasonable reaction mechanisms which were then further elucidated by calculations. MP2, B3-LYP and G3 levels of theory were employed to obtain the structures corresponding to energy minima and transition states and thus to obtain a complete potential energy surface for each system. A major focus of this work was to investigate the unimolecular reactions of some ion-molecule complexes, especially the isomerizations that take place within them and then to discover the mechanisms by which such reactions take place. Particular attention was devoted to ion-molecule complexes that comprise ketones (including aldehydes), enols and distonic ions of alcohols. The first two systems studied were acetaldehyde associated with the distonic methanol cation (•CH2OH2 +), [CH3CHO/H+O(H)CH2 •], and with its conventional isomer (CH3OH +•), [CH3CHO/+•HOCH3]. The isomerization barrier for ionized acetaldehyde to rearrange to its enol isomer, vinyl alcohol CH2CHOH+•, was lowered significantly (by 133 kJ/mol) by its association with •CH 2OH2+. This reaction resulted from a H +/H• transfer mechanism, involving a transition state of low energy requirement. In contrast, the CH3OH +• ion did not facilitate the rearrangement of acetaldehyde to its enol ion. Similar observations were obtained for ion-molecule complexes of acetone and methanol, [(CH3)2C=O/H+O(H)CH 2•] and [(CH3)2C=O/ +•HOCH3]. One metastable ion dissociation of the latter involved the loss of a methyl radical, producing a new [C3H 7O2]+ isomer, [CH3C+···(H)OCH 3], whose structure was assigned by calculations. A water molecule is one of the smallest species that have been used as a catalyst within an ion-molecule complex, thus the gas-phase reactions of the ion [CH3CHO/H2O]+• were also investigated in this thesis. The metastable ion (MI) mass spectrum revealed that this ion-molecule complex decomposed spontaneously by the losses of H 2O, CO and •CH3. Hydrogen-bridged water complexes were found to be the major products of the losses of CO and •CH3. The CO loss produced the [•CH 3···H3O+] ion and involved a backside displacement mechanism. The product ions arising from • CH3 loss (via two different reaction channels) were assigned by theory to be the isomers, [OC···H3O +] and [CO···H3O+], and their 298 K enthalpy values, calculated at the G3 level of theory are Delta fH[OC···H3O+] = 420 kJ/mol and DeltafH[CO···H3O+ ] = 448 kJ/mol. (Abstract shortened by UMI.)
Unterschätztes Treibhausgas Methan
Creators: name: Appelhans, Johanna
name: Böttcher, Christian
name: Kessler, Kai
name: Mielke, Christian
name: Nowack, Anja
name: Purr, Katja
name: Schwetje, Anja
name: Sorg, Diana
name: Tambke, Jens
Publisher: name: Umweltbundesamt
Year: 2022
Subjects: subject: Methan
subject: Treibhausgas
subject: Klimaschutz
subject: Ozonbildung
subject: Emissionsminderung
subject: Landwirtschaft
subject: Abfallwirtschaft
subject: Energiewirtschaft
subject: Klima | Energie
subject: Luft
subject: Abfall | Ressourcen
subject: Landwirtschaft

description: Methan ist nach Kohlendioxid das zweitwichtigste Treibhausgas. Daneben ist Methan ein wichtiger Vorläuferstoff für die Bildung von bodennahem Ozon. Ozon ist mit negativen Gesundheitseffekten verbunden und schädigt Ökosysteme und Nutzpflanzen. Eine Minderung der Methanemissionen trägt also sowohl zum Klimaschutz als auch zum Schutz der menschlichen Gesundheit und zum Schutz von Ökosystemen bei. Es ist daher wichtig, in den kommenden Jahren weltweit eine Minderung der Methanemissionen anzustoßen und weiter voranzubringen. Seit einigen Jahren gibt es sowohl auf internationaler als auch auf europäischer Ebene Bestrebungen, die Methanemissionen deutlich zu senken und konkrete Minderungsziele festzulegen. Trotz der angestoßenen Initiativen zur Methanminderung ist jedoch vielen Menschen noch nicht bewusst, wie notwendig eine Reduzierung der CH4-Emissionen ist und welchen Nutzen sie bringen kann. Das Positionspapier des Umweltbundesamtes informiert über die Wirkungen und die wichtigsten Emissionsquellen von Methan und zeigt konkrete Handlungsempfehlungen und Maßnahmen zur Methanreduktion auf nationaler Ebene und weltweit auf. Das UBA-Papier richtet sich vor allem an politische Entscheidungsträger*innen. Quelle: www.umweltbundesamt.de
description: Methan ist nach Kohlendioxid das zweitwichtigste ⁠Treibhausgas⁠. Daneben ist Methan ein wichtiger Vorläuferstoff für die Bildung von bodennahem Ozon. Ozon ist mit negativen Gesundheitseffekten verbunden und schädigt Ökosysteme und Nutzpflanzen. Eine Minderung der Methanemissionen trägt also sowohl zum ⁠Klimaschutz⁠ als auch zum Schutz der menschlichen Gesundheit und zum Schutz von Ökosystemen bei. Es ist daher wichtig, in den kommenden Jahren weltweit eine Minderung der Methanemissionen anzustoßen und weiter voranzubringen. Seit einigen Jahren gibt es sowohl auf internationaler als auch auf europäischer Ebene Bestrebungen, die Methanemissionen deutlich zu senken und konkrete Minderungsziele festzulegen. Trotz der angestoßenen Initiativen zur Methanminderung ist jedoch vielen Menschen noch nicht bewusst, wie notwendig eine Reduzierung der CH4-Emissionen ist und welchen Nutzen sie bringen kann.Das Positionspapier des Umweltbundesamtes informiert über die Wirkungen und die wichtigsten Emissionsquellen von Methan und zeigt konkrete Handlungsempfehlungen und Maßnahmen zur Methanreduktion auf nationaler Ebene und weltweit auf. Das ⁠UBA⁠-Papier richtet sich vor allem an politische Entscheidungsträger*innen.
DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer
Creators: name: Mamlouk, Soulafa
name: Childs, Liam Harold
name: Aust, Daniela
name: Heim, Daniel
name: Melching, Friederike
name: Oliveira, Cristiano
name: Sers, Christine [U. V. M.]
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Cancer
subject: Tumour heterogeneity
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Genetic heterogeneity between and within tumours is a major factor determining cancer progression and therapy response. Here we examined DNA sequence and DNA copy-number heterogeneity in colorectal cancer (CRC) by targeted high-depth sequencing of 100 most frequently altered genes. In 97 samples, with primary tumours and matched metastases from 27 patients, we observe inter-tumour concordance for coding mutations; in contrast, gene copy numbers are highly discordant between primary tumours and metastases as validated by fluorescent in situ hybridization. To further investigate intra-tumour heterogeneity, we dissected a single tumour into 68 spatially defined samples and sequenced them separately. We identify evenly distributed coding mutations in APC and TP53 in all tumour areas, yet highly variable gene copy numbers in numerous genes. 3D morpho-molecular reconstruction reveals two clusters with divergent copy number aberrations along the proximal–distal axis indicating that DNA copy number variations are a major source of tumour heterogeneity in CRC.
The 2dF Galaxy Redshift Survey: Power-spectrum analysis of the final data set and cosmological implications
Creators: name: Cole, Shaun
name: Percival, Will J.
name: Peacock, John A.
name: Norberg, Peder
name: Baugh, Carlton M.
name: Frenk, Carlos S.
name: Baldry, Ivan
name: Bland-Hawthorn, Joss
name: Bridges, Terry
name: Cannon, Russell
name: Colless, Matthew
name: Collins, Chris
name: Couch, Warrick
name: Cross, Nicholas J G
name: Dalton, Gavin
name: Eke, Vincent R.
name: De Propris, Roberto
name: Driver, Simon P.
name: Efstathiou, George
name: Ellis, Richard S.
name: Glazebrook, Karl
name: Jackson, Carole
name: Jenkins, Adrian
name: Lahav, Ofer
name: Lewis, Ian
name: Lumsden, Stuart
name: Maddox, Steve
name: Madgwick, Darren
name: Peterson, Bruce A.
name: Sutherland, Will
name: Taylor, Keith
Publisher: name: Swinburne
Year: 2024

description: We present a power-spectrum analysis of the final 2dF Galaxy Redshift Survey (2dFGRS), employing a direct Fourier method. The sample used comprises 221 414 galaxies with measured redshifts. We investigate in detail the modelling of the sample selection, improving on previous treatments in a number of respects. A new angular mask is derived, based on revisions to the photometric calibration. The redshift selection function is determined by dividing the survey according to rest-frame colour, and deducing a self-consistent treatment of k-corrections and evolution for each population. The covariance matrix for the power-spectrum estimates is determined using two different approaches to the construction of mock surveys, which are used to demonstrate that the input cosmological model can be correctly recovered. We discuss in detail the possible differences between the galaxy and mass power spectra, and treat these using simulations, analytic models and a hybrid empirical approach. Based on these investigations, we are confident that the 2dFGRS power spectrum can be used to infer the matter content of the universe. On large scales, our estimated power spectrum shows evidence for the 'baryon oscillations' that are predicted in cold dark matter (CDM) models. Fitting to a CDM model, assuming a primordial ns= 1 spectrum, h= 0.72 and negligible neutrino mass, the preferred parameters are Ωmh= 0.168 ± 0.016 and a baryon fraction Ωb/Ωm= 0.185 ± 0.046 (1σ errors). The value of Ωmh is 1σ lower than the 0.20 ± 0.03 in our 2001 analysis of the partially complete 2dFGRS. This shift is largely due to the signal from the newly sampled regions of space, rather than the refinements in the treatment of observational selection. This analysis therefore implies a density significantly below the standard Ωm= 0.3: in combination with cosmic microwave background (CMB) data from the Wilkinson Microwave Anisotropy Probe (WMAP), we infer Ωm= 0.231 ± 0.021 .
Digital Play and Learning in Young Children
Creators: name: Guy, Jessica
Publisher: name: Swinburne
Year: 2024

description: This research investigated the impact of touchscreen and other digital media on young children's play, learning, and development. Utilising systematic and narrative literature reviews alongside empirical studies, it examined whether children could acquire knowledge via screen-based media and assessed the implications for social interactions, play, and overall well-being. Findings indicated positive educational outcomes from touchscreen use and nuanced effects on parent-child interactions. This research highlighted the importance of a multifaceted approach integrating developmental psychology, learning theories, and public health to optimise children’s digital media use and offers critical insights for educators and caregivers for enhancing developmental outcomes in the digital age.
Satisfaction of sojourner couples residing in Nepal: The mediating role of social support and personal and couple resources.
Creators: name: James, Joan Susan.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Psychology, Social.

description: Improvements in transportation have made it more feasible for families to relocate greater distances, sometimes even to other countries. Although this is now a frequent occurrence, the family dynamics associated with adjusting to a new culture have been virtually ignored by researchers. When investigating sojourner families (families who live in foreign countries), researchers rarely integrate the family stress literature, which focuses on stresses incurred in one's native country, and the sojourner literature, which is based on stresses inherent in living in a foreign country. The aim of the present study was to develop and test a model of intercultural family relocation based on an integration of the family stress and sojourner literatures. The model, based on the Double ABCX model, was tested with expatriate couples $(N=205)$ stationed in Nepal with aid agencies, mission organizations, and corporations. More specifically, personal resources identified in the sojourner literature and traditional family stress mediators were investigated to determine whether they played a significant role in mediating the stress-satisfaction relation. The model was tested using structural equation modeling. The results indicated that personal resources (locus of control and self-esteem) and social support did mediate the stress-satisfaction relation, as hypothesized. The family variables, on the other hand, coherence (confidence and acceptance) and couple resources (communication, adaptability, and cohesion), did not directly influence the stress-satisfaction relation. Even though the Double ABCX model is one of the most popular models in family psychology, it was only partially supported by empirical investigation with the sojourner couples living in Nepal. Thus, the results call into question the model's overall validity and generalizability. Future research will need to address this question by testing the model with families in various contexts.
Effiziente Trocknung durch Inline-Messtechnik (Factsheet)
Creators: name: NEFI New Energy for Industry
Publisher: name: NEFI
Year: 2024
Subjects: NEFI
Innovationsnetzwerk
Energie
Industrie
New Energy for Industry
Klima- und Energiefonds
Vorzeigeregion
Trocknung
Inline-Messtechnik
Produzierende Industrie
Prozessoptimierung
Produktfeuchtesensorik
Nachhaltigkeit

description: Trocknungsprozesse sind ein entscheidender Bestandteil in einer Vielzahl von Industriezweigen, darunter Lebensmittel, Chemie, Pharma, Keramik, Zement, Holz und viele mehr. Diese Branchen umfassen eine breite Palette von Produkten mit unterschiedlichen Typen und Zuständen, einschließlich grob- und feinkörnigen Pulvern, Flüssigkeiten und Feststoffen. Angesichts der Vielfalt der Produkte und der Bedeutung der Produktqualität ist eine präzise Prozesskontrolle und Qualitätsüberwachung von größter Relevanz, um sicherzustellen, dass die Trocknungsprozesse effizient und zuverlässig ablaufen.
Gender differences in a resources-demands model in the general population
Creators: name: Kocalevent, Rüya-Daniela
name: Klapp, Burghard F.
name: Albani, Cornelia
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 100 Philosophie und Psychologie::150 Psychologie

description: Background The population-based study examined postulated effects, derived from a resources-demands-model about gender-related aspects of self-efficacy, optimism, chronic stress, and exhaustion. Methods Data acquisition was carried out by a market research institute with a multi-topic questionnaire in the general population (N = 2,552). Instruments administered were the Questionnaire for Self-Efficacy and Optimism, the Trier Inventory for Chronic Stress, and the Chalder-Fatigue-Scale. Households and target persons were selected randomly. The analyses focused on structural equation modeling. Results There were significant differences in structural relations among the resource paths. In particular, significant gender differences were found with respect to self-efficacy, and among the exhaustion paths, namely in the mental dimension of exhaustion. The observed measures of chronic stress were found to be operating equivalently for both genders. Results suggest that resources play an important role in the understanding of how chronic stress is preceded and may lead to exhaustion in both genders. Conclusion Personal resources seem to be more expressed by men than by woman, for whom the relation of resources to health is of greater importance than for men.
title: How to behave? Visitor guidelines for the Antarctic
title: How to behave? Visitor guidelines for the Antarctic
titleType: AlternativeTitle
Creators: name: (:Unkn) Unknown
Publisher: name: Umweltbundesamt
Year: 2020
Subjects: subject: Antarktisvertrag
subject: Fremdenverkehr
subject: Öffentlichkeitsarbeit
subject: Verhaltensmuster
subject: Antarktis
subject: Antarctica
subject: antarctic agreement
subject: tourism
subject: public relations
subject: behaviour pattern
subject: Nachhaltigkeit | Strategien | Internationales
subject: Sustainability | Strategies | International matters

description: Since the beginning of Antarctic tourism, which focuses mainly on the Antarctic Peninsula, visitor numbers have increased considerably. In order to maintain the unique fauna and flora in its original state despite the growing visitor interest, internationally binding visitor guidelines to the Antarctic apply. Please observe these guidelines during your stay and make a personal contribution to the protection of the Antarctic. Quelle: https://www.umweltbundesamt.de
description: Since the beginning of Antarctic tourism, which focuses mainly on the Antarctic Peninsula, visitor numbers have increased considerably. In order to maintain the unique fauna and flora in its original state despite the growing visitor interest, internationally binding visitor guidelines to the Antarctic apply. Please observe these guidelines during your stay and make a personal contribution to the protection of the Antarctic.
Evaluation of buccal swabs for pharmacogenetics
Creators: name: Aloise, Martin N
name: Dawes, Diana
name: Dempster, Maryn G
name: Fraser, Robert
name: Paterson, Andrea
name: Stanley, Paul
name: Suarez-Gonzalez, Adriana
name: Dawes, Martin
name: Katzov-Eckert, Hagit
name: Ang, J. Sidney
Publisher: name: BioMed Central
Year: 2018

description: Objective: A simple, non-invasive sample collection method is key for the integration of pharmacogenetics into clinical practice. The aim of this study was to gain samples for pharmacogenetic testing and evaluate the variation between dry-flocked and sponge-tipped buccal swabs in yield and quality of DNA isolated. Results: Thirty-one participants collected samples using dry-flocked swabs and sponge-tipped swabs. Samples were assessed for DNA yield, quality and genotyping performance on a qPCR OpenArray platform of 28 pharmacogenetic SNPs and a CYP2D6 TaqMan copy number variant. DNA from sponge-tipped swabs had a significantly greater yield compared to DNA collected with dry-flocked swabs (p = 4.4 × 10−7). Moreover, highest genotyping call rates across all assays and highest CNV confidence scores were observed in DNA samples collected from sponge-tipped swabs (97% vs. 54% dry-flocked swabs; 0.99 vs. 0.88 dry-flocked swabs, respectively). Sample collection using sponge-tipped swabs provides a DNA source of sufficient quantity and quality for pharmacogenetic variant detection using qPCR.
The 2dF Galaxy Redshift Survey: Luminosity functions by density environment and galaxy type
Creators: name: Croton, Darren
name: Farrar, Glennys R.
name: Norberg, Peder
name: Colless, Matthew
name: Peacock, John A.
name: Baldry, I. K.
name: Baugh, C. M.
name: Bland-Hawthorn, J.
name: Bridges, T.
name: Cannon, R.
name: Cole, S.
name: Collins, C.
name: Couch, Warrick
name: Dalton, G.
name: De Propris, R.
name: Driver, S. P.
name: Efstathiou, G.
name: Ellis, R. S.
name: Frenk, C. S.
name: Glazebrook, Karl
name: Jackson, C.
name: Lahav, O.
name: Lewis, I.
name: Lumsden, S.
name: Maddox, S.
name: Madgwick, D.
name: Peterson, B. A.
name: Sutherland, W.
name: Taylor, K.
Publisher: name: Swinburne
Year: 2024

description: We use the 2dF Galaxy Redshift Survey to measure the dependence of the bJ-band galaxy luminosity function on large-scale environment, defined by density contrast in spheres of radius 8 h−1 Mpc , and on spectral type, determined from principal component analysis. We find that the galaxy populations at both extremes of density differ significantly from that at the mean density. The population in voids is dominated by late types and shows, relative to the mean, a deficit of galaxies that becomes increasingly pronounced at magnitudes brighter than MbJ−5log10h≲−18.5 . In contrast, cluster regions have a relative excess of very bright early-type galaxies with MbJ−5log10h≲−21 . Differences in the mid- to faint-end population between environments are significant: at MbJ−5log10h=−18 early- and late-type cluster galaxies show comparable abundances, whereas in voids the late types dominate by almost an order of magnitude. We find that the luminosity functions measured in all density environments, from voids to clusters, can be approximated by Schechter functions with parameters that vary smoothly with local density, but in a fashion that differs strikingly for early- and late-type galaxies. These observed variations, combined with our finding that the faint-end slope of the overall luminosity function depends at most weakly on density environment, may prove to be a significant challenge for models of galaxy formation.
title: Hallazgo de variz aneurismática del cuello en ecografía
Creators: name: Arenas López, Sonsoles
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Aneurysms
subject: Imaging sequences
subject: Ultrasound-Colour Doppler
subject: Ultrasound
subject: Veins / Vena cava
subject: Head and neck

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Hacer una revisión de esta patología , poco frecuente, que puede afectar a cualquier parte del sistema vascular,
con más frecuencia al sistema arterial,
pero también al venoso. La dilatación venosa,
afecta con preferencia a la vena yugular...
title: Papel actual de la Resonancia Magnética en el manejo y diagnóstico diferencial de la rombencefalitis aguda de causa infecciosa.
Creators: name: Gómez Herrera, Juan Jesus
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Neoplasia
subject: Inflammation
subject: Infection
subject: Localisation
subject: Education
subject: MR
subject: Neuroradiology brain

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Mostrar las características en Resonancia Magnética de la rombencefalitis aguda infecciosa. Señalar los hallazgosclavesen Resonancia Magnética que permiten realizar un diagnóstico diferencial adecuadoentrelas diferentes patologías que pueden...
Assessing and Developing Approaches for Improved Practical Question Answering System for Healthcare
Creators: name: Nguyen, Duy Anh
Publisher: name: Swinburne
Year: 2024

description: In recent years, there has been considerable advancement in Deep Learning research which has led to impressive results in many Natural Language Processing tasks including question answering. Complex domains such as healthcare are challenging due to several reasons, one of which is the lengthy context and answer that the machine needs to process. In this work, I developed techniques that allow question answering systems to perform more efficiently and effectively in such scenarios. This research contributes to the effort of building practical systems that assist humans in information retrieval services.
Equivalent Martingale measures and option pricing in jump-diffusion markets
Creators: name: Dranev, Yury
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Engineering, Electronics and Electrical.

description: One of the key questions in financial mathematics is the choice of an appropriate model for the financial market. There are a number of models available, such as Geometrical Brownian motion and different types of Levy processes, that are not general enough to reflect all the characteristics of fluctuations in stock price but for which the parameters can be estimated with relative ease. There are more general semimartingale models for which parameter estimation and numerical calculation become very difficult questions. The goal of this thesis is to present a tractable model for which we can carry out computations, and it seems that by varying the parameters this model can be related to real market data. We will use the equivalent measure approach to obtain estimates of the price of European call options for our model. Since our market is incomplete, a consequence of the inclusion of jump processes in the model, we will choose the "best" equivalent martingale measure by applying various techniques and compare the results for different choices. We will also illustrate how this theory works on particular examples. We consider applications not only to the cases of continuous and Levy process markets but also to cases that reflect the main advantages of our jump diffusion model. Finally we numerically illustrate option pricing in our setting.
Decolonizing Home Economics : A Descriptive Literature Review
Creators: name: Mah, Gelaina
Publisher: name: The University of British Columbia
Year: 2025

description: This project explores how current literature informs the process of decolonizing curriculum and pedagogy in Home Economics education. Through a descriptive literature review, this gradating project examines key elements of decolonization, including self-work, collaboration, and the recognition that cultures are not commodities. Additionally, the project investigates approaches to Indigenization and provides recommendations on how to Indigenize the Home Economics curriculum by integrating Indigenous knowledge systems, pedagogical practices, and perspectives. Findings highlight the need for educators and the field of Home Economics to engage in critical self-reflection, build meaningful relationships with Indigenous communities, and challenge colonial frameworks that commodify culture. The project shows that decolonizing Home Economics requires a shift from Eurocentric perspectives toward holistic, relational, and land-based learning that honours Indigenous ways of knowing.
The roles of AMP-activated protein kinase and uncoupling protein-3 in skeletal muscle fuel metabolism
Creators: name: Costford, Sheila
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Chemistry, Biochemistry.

description: The prevalence of obesity has increased at an alarming rate over the past few decades. Obesity is caused by a positive energy balance and is associated with several major health risks, such as cardiovascular disease, type 2 diabetes mellitus (T2DM) and some cancers. This research focuses on two proteins involved in energy regulation: AMP-activated protein kinase (AMPK) and uncoupling protein-3 (UCP3). AMPK functions to maintain cellular and whole body energy homeostasis. Studies in experimental animals have demonstrated that activation of AMPK in skeletal muscle protects against insulin resistance, T2DM and obesity. The first objective of this research was to determine whether R225W, a rare mutation in the muscle-specific gamma3 subunit of AMPK, affects activity and function in human muscle. R225W was associated with increased basal and AMP-stimulated AMPK activities, increased muscle glycogen and decreased intramuscular triglyceride (IMTG). These findings are consistent with an important role for AMPKgamma3 in human muscle energy metabolism and highlight the attractiveness of this gamma isoform as a pharmaceutical target for the treatment of metabolic disorders associated with obesity, such as T2DM. UCP3 is a poorly understood mitochondrial inner membrane protein expressed predominantly in skeletal muscle. Although the function of UCP3 is unknown, the literature supports roles for UCP3 in facilitating fatty acid oxidation and mitigating oxidative stress. Moreover, lower levels of UCP3 have been observed in muscle of T2DM patients. The second objective of this research was to determine if UCP3 protects from the development of insulin resistance. UCP3 -/-, wildtype, and UCP3tg overexpressor mice were fed a 10% or 45% fat diet for 4 or 8 months. Although UCP3 overexpression protected against the accumulation of IMTG, paradoxically, both UCP3tg and UCP3 -/- mice were protected from the development of glucose intolerance and insulin resistance. UCP3tg mice were, however, protected from the development of obesity, whereas UCP3 -/- mice were not. These results therefore support a role for UCP3 in preventing the accumulation of triglyceride in both muscle and adipose tissue. It is anticipated that these findings will lead to a better understanding of the mechanisms involved in the development of disorders of energy regulation.
title: Título:  Sellado del trayecto de punción transparenquimatoso para los procedimientos percutáneos hepato-biliares y renales
Creators: name: Trueba Arguiñarena, Francisco Javier
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Kidney
subject: Interventional non-vascular
subject: Percutaneous
subject: Puncture
subject: Instrumentation
subject: Liver

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
En los procedimientos intervencionistas transparenquimatosos sobre las vías biliares ó urinarias,
al retirar el introductor empleado pueden producirse sangrados,
fístulas vasculares,
biliares ó urinarias.
Describimos una técnica para el sellado...
Adding a new dimension to the upward drawing
Creators: name: Rakotomalala, Livaniaina Hary
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Computer Science.

description: In this thesis, we principally investigated the visualization of data that can be represented by an ordered set by means of its upward drawing (Hasse Diagrams). Difficulties are such that "Upward Planarity Testing" is NP-complete [GT95] and "Upward Crossing Minimization" is NP-Hard [Lin94]. Also, the "drawing area" requirement of upward planar directed graphs using straight-line edges on a grid has an exponential lower bound [DTT92]. We present a new approach of drawing Ordered Sets which is a modified version of Hasse Diagrams. The new restriction is that all existing edges are only directed from "Bottom to Top" (upward) and from "Left to Right" (LR). This new dimension is motivated by the rise of a flow of comparability between elements and thus produces readability improvement. The idea is achieved by using special types of decompositions of the ordered set P that will serve as the underlying structure for the drawing. We propose an O( n * width(P)) algorithm which satisfies this new requirement. Furthermore, this new idea is studied for the subclass of N-free ordered sets. We present some techniques of improving the readability by locally reducing crossings around some component of the drawing. We also present a polynomial algorithm which brings an enhancement of the overall picture. The resulting rectangle used has an O(n 2) area. Additionally, to have an approximation of the general ordered set drawing, we present a space-efficient algorithm to convert any ordered set into N-Free.