cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Next-step conditioned deep convolutional neural networks improve protein secondary structure prediction
Creators: name: Akosua Busia
name: Jaitly, Navdeep
Publisher: name: F1000Research
Year: 2017

description: Recently developed deep learning techniques have significantly improved the accuracy of various speech and image recognition systems. We show how to adapt some of these techniques to create a novel chained convolutional architecture with next-step conditioning for improving performance on protein sequence prediction problems. We explore its value by demonstrating its ability to improve performance on eight-class secondary structure prediction. We first establish a state-of-the-art baseline by adapting recent advances in convolutional neural networks which were developed for vision tasks. This model achieves 70.0% per amino acid accuracy on the CB513 benchmark dataset without use of standard performance-boosting techniques such as ensembling or multitask learning. We then improve upon this state-of-the-art result using a novel chained prediction approach which frames the secondary structure prediction as a next-step prediction problem. This sequential model achieves 70.3% Q8 accuracy on CB513 with a single model; an ensemble of these models produces 71.4% Q8 accuracy on the same test set, improving upon the previous overall state of the art for the eight-class secondary structure problem. Our models are implemented using TensorFlow, an open-source machine learning software library available at TensorFlow.org
Model-driven user interface generation and adaptation in process-aware information systems
Creators: name: Kolb, Jens
name: Hübner, Paul
name: Reichert, Manfred
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: Model-driven user interfaces
subject: Process-aware information systems
subject: DDC 004 / Data processing & computer science
subject: Computer-aided software engineering
subject: Human-computer interaction
subject: Information management systems
subject: Benutzeroberfläche

description: The increasing adoption of process-aware information systems (PAISs) has resulted in a large number of implemented business processes. To react on changing needs, companies should be able to quickly adapt these process implementations if required. Current PAISs, however, only provide mechanisms to evolve the schema of a process model, but do not allow for the automated creation and adaptation of their user interfaces (UIs). The latter may have a complex logic and comprise, for example, conditional elements or database queries. Creating and evolving the UI components of a PAIS manually is a tedious and error-prone task. This technical report introduces a set of patterns for transforming fragments of a business process model, whose activities are performed by the same user role, to UI components of the PAIS. In particular, UI logic can be expressed using the same notation as for process modeling. Furthermore, a transformation method is introduced, which applies these patterns to automatically derive UI components from a process model by establishing a bidirectional mapping between process model and UI. This mapping allows propagating UI changes to the process model and vice versa. Overall, our approach enables process designers to rapidly develop and update complex UI components in PAISs.
Assessing reproducibility of metagenomics studies and diversity of public transport systems microbiome profiles of New York, Boston and Sacramento cities
Creators: name: Frolova, Alina
Publisher: name: F1000Research
Year: 2017

description: This work was submitted within open CAMDA (Critical Assessment of Massive Data Analysis) challenge. As a new members of MetaSUB Consortium we were greatly interested in analyzing Boston, New York and Sacramento cities microbiome profiles to point out important issues and problems before upcoming global City Sampling Day 2017. Here we performed detailed quality control of raw sequences, evaluated collected metadata in the context of creating uniform specification for data collection, assessed reproducibility of OTU abundances calculation, and investigated biodiversity vs biolocation. We conclude that it is important to sample fewer, more controlled environments with greater specificity and uniform coverage of meta-variables.
Attitudes towards risk and optimal use of inputs in maize production in the Mekong Delta, Vietnam
Creators: name: Le, V.D.
name: Pham, L.T.
Publisher: name: Unknown
Year: 2024
Subjects: subject: Crop Production/Industries
subject: Production Economics
subject: Risk and Uncertainty
subject: Risk attitude
subject: maize production
subject: input use
subject: profit maximization

description: The paper is aimed at measuring the risk attitude of maize farmers and testing the relationship between farmers' risk attitudes and optimal use of inputs in production. The experimental method of Eckel and Grossman (2002) associated with the constant partial risk utility function was employed to measure the farmers’ risk attitude. Then, allocative efficiency coefficients were calculated from the output elasticities of inputs estimated from the Cobb-Douglas production function associated with the profit-maximizing condition in using inputs. The data was collected from a survey of 130 farm households located in large and concentrated maize production areas in the Mekong Delta. It is found that the majority of farmers are found to be risk-averse, accounting for 69.05%. Generally, the more risk averse the farmers are, the less purchased inputs are used in production. Then, most of farmers are not able to maximize profits.
Genome-based comparison of all species of the genus moorella, and status of the species moorella thermoacetica and moorella thermoautotrophica
Creators: name: Redl, Stephanie
name: Poehlein, Anja
name: Esser, Carola
name: Bengelsdorf, Frank R.
name: Jensen, Torbjørn Ø.
name: Jendresen, Christian B.
name: Tindall, Brian J.
name: Daniel, Rolf
name: Dürre, Peter
name: Nielsen, Alex T.
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: anaerobic
subject: gas fermentation
subject: syngas fermentation
subject: Moorella thermoacetica
subject: Moorella
subject: thermophile
subject: acetogen
subject: DDC 570 / Life sciences
subject: Microbial biotechnology
subject: Fermentation
subject: Thermophilic microorganisms
subject: Fermentation
subject: Thermophile Bakterien
subject: Acetogene Bakterien

description: Fermentation of gases provides a promising opportunity for the production of biochemicals from renewable resources, which has resulted in a growing interest in acetogenic bacteria. Thermophilic organisms provide potential advantages for the fermentation of, e.g., syngas into for example volatile compounds, and the thermophiles Moorella thermoacetica and Moorella thermoautotrophica have become model organisms of acetogenic metabolism. The justification for the recognition of the closely related species M. thermoautotrophica has, however, recently been disputed. In order to expand knowledge on the genus, we have here genome sequenced a total of 12 different M. thermoacetica and M. thermoautotrophica strains. From the sequencing results, it became clear that M. thermoautotrophica DSM 1974T consists of at least two different strains. Two different strains were isolated in Lyngby and Ulm from a DSM 1974T culture obtained from the DSMZ (Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH, Brunswick, Germany). Phylogenetic analysis revealed a close relationship between all the sequenced genomes, suggesting that the two strains detected in the type strain of the species M. thermoautotrophica could not be distinguished at the species level from M. thermoacetica. Despite genetic similarities, differences in genomic features were observed between the strains. Differences in compounds that can serve as carbon and energy sources for selected strains were also identified. On the contrary, strain DSM 21394, currently still named M. thermoacetica, obviously represents a new Moorella species. In addition, based on genome analysis and comparison M. glycerini NMP, M. stamsii DSM 26217T, and M. perchloratireducens An10 cannot be distinguished at the species level. Thus, this comprehensive analysis provides a significantly increased knowledge of the genetic diversity of Moorella strains.
АГРОЭКОЛОГИЧЕСКОЕ ИСПЫТАНИЕ ОДНОЛЕТНИХ КОРМОВЫХ КУЛЬТУР В НОВГОРОДСКОЙ ОБЛАСТИ
Creators: name: ШКОДИНА Е.П., ВОЛОДИН А.Б.
Publisher: name: Федеральный аграрный научный центр Северо-Востока имени Н.В. Рудницкого (Киров)
Year: 2018

description: Установлена возможность получения высокого урожая ка- чественной кормовой массы могара, пайзы, суданской травы и сорго- суданковых гибридов в условиях Новгородской области. Выделены наиболее продуктивные сорта и гибриды этих культур.
Entwicklung eines Simulators zur Nachbildung des lastabhängigen Spannungsverhaltens von Stromerzeugungsaggregaten
Creators: name: Kern, Heinrich
Publisher: name: Technische Hochschule Ulm
Year: 2023
Subjects: subject: DDC 600 / Technology (Applied sciences)
subject: Notstromaggregat
subject: Hubkolbenmotor
subject: Elektrowerkzeugindustrie
subject: Aggregat
subject: Prüftechnik

description: In der vorliegenden Arbeit geht es um die Entwicklung eines Simulators, mit dem das lastabhängige Spannungsverhalten von Stromerzeugungsaggregaten mit Hubkolben-Verbrennungsmotor nachgebildet werden kann. Dies ermöglicht eine Prüfung von Elektrowerkzeugen auf Funktionsfähigkeit, wenn sie an der störungsbehafteten Ausgangsspannung von mobilen Stromerzeugern betrieben werden. Nach einer Marktrecherche werden Stromerzeuger unterschiedlichen Typs beschafft: Ein Inverter und zwei Geräte mit kondensatorgeregeltem Synchrongenerator. Durch Beaufschlagung von verschiedenen Lastprofilen werden parasitäre Effekte in der Ausgangsspannung provoziert und analysiert. Dabei werden drehzahlabhängige Frequenz- und Spannungsschwankungen erkannt, die innerhalb von 0,5–1,5 Sekunden wieder abklingen. Durch die hohe Impedanz der Stromerzeuger ergibt sich in Verbindung mit phasenanschnitt-gesteuerten Elektrowerkzeugen ein Reihenschwingkreis, der zu einer gedämpften Schwingung von bis zu 3,4 kHz führt. Um diese Effekte in Abhängigkeit des Laststroms nachzubilden, wird basierend auf dem Verstärker PAS-5000 ein Simulationskonzept entwickelt. Ein Teil der Simulation wird über eine künstliche Netzimpedanz mit physikalischen Bauteilen realisiert. Die relativ langsamen, drehzahlabhängigen Effekte werden über ein PXIe-Echtzeitsystem von National Instruments berechnet. In MATLAB werden aus gemessenen Ein-und Ausgangsgrößen Übertragungsfunktionen bestimmt. Die daraus abgeleiteten Rekursionsformeln werden mit LabVIEW in ein Prüfprogramm implementiert. Nach Aufbau des Simulators erfolgt die Verifikation: Strom, Spannung und Frequenz am Simulator werden bei identischem Lastprofil mit den Messreihen am realen Stromerzeuger verglichen. Es zeigt sich, dass die gedämpfte Schwingung bei richtiger Dimensionierung der Netzimpedanz gut simuliert werden kann. Die langsameren Frequenz- und Spannungsschwankungen werden allerdings nur bei den Stromerzeugern mit Synchrongenerator in ausreichender Annäherung nachgebildet. Der Inverter-Stromerzeuger ist durch seine Mikrocontroller-Steuerung nur bedingt durch Übertragungsfunktionen modellierbar. Hard- und Software des Simulators werden erfolgreich in Betrieb genommen. Der Simulator wird bei Festool weiterentwickelt: Im nächsten Schritt soll die physikalische Netzimpedanz durch eine Softwaresimulation ersetzt werden.
Additional file 1 of A blueprint for patient and public involvement in the development of a reporting guideline for systematic reviews of outcome measurement instruments: PRISMA-COSMIN for OMIs 2024
Creators: name: Elsman, Ellen B. M.
name: Smith, Maureen
name: Hofstetter, Catherine
name: Gavin, Frank
name: Jobson, Estelle
name: Markham, Sarah
name: Ricketts, Juanna
name: Baba, Ami
name: Butcher, Nancy J.
name: Offringa, Martin
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: Additional file 1. Feedback from the evaluation surveys administered after the onboarding session and Delphi study.
sj-docx-1-tam-10.1177_17588359231220506 – Supplemental material for Nomogram to predict the presence of PSMA-negative but FDG-positive lesion in castration-resistant prostate cancer: a multicenter cohort study
Creators: name: Pan, Jian
name: Zhang, Tingwei
name: Chen, Shouzhen
name: Bu, Ting
name: Zhao, Jinou
name: Ni, Xudong
name: Shi, Benkang
name: Gan, Hualei
name: Wei, Yu
name: Wang, Qifeng
name: Wang, Beihe
name: Wu, Junlong
name: Song, Shaoli
name: Wang, Feng
name: Liu, Chang
name: Ye, Dingwei
name: Zhu, Yao
Publisher: name: SAGE Journals
Year: 2024
Subjects: Oncology and Carcinogenesis not elsewhere classified
Aged Health Care
Pharmacology and Pharmaceutical Sciences not elsewhere classified
Respiratory Diseases

description: Supplemental material, sj-docx-1-tam-10.1177_17588359231220506 for Nomogram to predict the presence of PSMA-negative but FDG-positive lesion in castration-resistant prostate cancer: a multicenter cohort study by Jian Pan, Tingwei Zhang, Shouzhen Chen, Ting Bu, Jinou Zhao, Xudong Ni, Benkang Shi, Hualei Gan, Yu Wei, Qifeng Wang, Beihe Wang, Junlong Wu, Shaoli Song, Feng Wang, Chang Liu, Dingwei Ye and Yao Zhu in Therapeutic Advances in Medical Oncology
sj-docx-1-pie-10.1177_09544089231223021 - Supplemental material for Comparative performance evaluation between ta-C and TiAlCrN coated tools during milling of additively manufactured CFRP composite
Creators: name: Das, Anshuman
name: Barrenkala, Dineshwar
name: Das, Sudhansu Ranjan
name: Patel, Saroj Kumar
name: Somani, Nalin
name: Kumar, Ch Sateesh
Publisher: name: SAGE Journals
Year: 2024
Subjects: Engineering not elsewhere classified
Materials Engineering not elsewhere classified

description: Supplemental material, sj-docx-1-pie-10.1177_09544089231223021 for Comparative performance evaluation between ta-C and TiAlCrN coated tools during milling of additively manufactured CFRP composite by Anshuman Das, Dineshwar Barrenkala, Sudhansu Ranjan Das, Saroj Kumar Patel, Nalin Somani and Ch Sateesh Kumar in Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering
Additional file 2 of A blueprint for patient and public involvement in the development of a reporting guideline for systematic reviews of outcome measurement instruments: PRISMA-COSMIN for OMIs 2024
Creators: name: Elsman, Ellen B. M.
name: Smith, Maureen
name: Hofstetter, Catherine
name: Gavin, Frank
name: Jobson, Estelle
name: Markham, Sarah
name: Ricketts, Juanna
name: Baba, Ami
name: Butcher, Nancy J.
name: Offringa, Martin
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: Additional file 2. Heatmap of evaluation surveys’ quantitative results.
The Role of the MAPK Signaling, Topoisomerase and Dietary Bioactives in Controlling Cancer Incidence
Creators: name: Selim, Khaled A.
name: Abdelrasoul, Hend
name: Aboelmagd, Mohamed
name: Tawila, Ahmed M.
Publisher: name: Universität Ulm
Year: 2017
Subjects: subject: dietary antioxidants
subject: MAPK kinases
subject: MAPK phosphatases
subject: ROS
subject: topoisomerase
subject: DDC 570 / Life sciences
subject: DDC 610 / Medicine & health
subject: Reactive Oxygen Species
subject: Mitogen-Activated Protein Kinase kinases
subject: Mitogen-Activated Protein Kinase phosphatases
subject: Pterocarpans
subject: DNA topoisomerases
subject: Functional food
subject: Antioxidants
subject: Reaktive Sauerstoffspezies
subject: MAP-Kinase
subject: DNS-Topoisomerase I
subject: Ernährung
subject: Functional Food
subject: Antioxidans

description: Reactive oxygen species (ROS) are common products of mitochondrial oxidative phosphorylation, xenobiotics metabolism and are generated in response to several environmental stress conditions. Some of them play important biochemical roles in cellular signal transduction and gene transcription. On the other hand, ROS are known to be involved in a wide range of human diseases, including cancer. The excessive production of such ROS together with disruption of homeostasis detoxifying mechanisms can mediate a series of cellular oxidative stresses. The oxidative stress of redundant free radicals production can lead to oxidative denaturation of cellular macromolecules including proteins, lipids and DNA. Moreover, oxidative damage is one of the major causes of DNA mutations, replication errors and genomic abnormalities which result in either inhibition or induction of transcription, and end with the disturbance of signal transduction pathways. Among affected signaling pathways are redox-sensitive kinases. The stimulation of these kinases induces several transcription factors through the phosphorylation of their module proteins. The activation of such pathways induces proliferation and cellular transformation. A diet rich in antioxidant compounds has potential health benefits, and there is a growing interest in the role of natural antioxidants in nutrition for prevention and cure of cancer diseases. A controversy has risen regarding the relation between antioxidants and the significant decrease in the risk of cancer incidence. In this review, we will focus on redox-sensitive kinases signaling pathways, highlighting the effects of dietary antioxidant on the prevention, incidence, prognosis or even treatment of human cancers. In addition, we will place emphasis on the chemical classes of pterocarpans as natural anti-oxidants/cancers as well as their underlying mechanisms of action, including their effects on MAPKs and topoisomerase activities.
sj-docx-1-ahd-10.1177_00914150231218934 - Supplemental material for Depressive Symptoms in Later Life in China: Situating “Long Arm” of Child Physical Maltreatment Within a Family Context
Creators: name: Han, Chengming
name: Bhatta, Tirth
name: Kahana, Eva
name: Kahana, Boaz
name: Gran, Brian
name: Zhou, Nan
Publisher: name: SAGE Journals
Year: 2024
Subjects: Geriatrics and Gerontology

description: Supplemental material, sj-docx-1-ahd-10.1177_00914150231218934 for Depressive Symptoms in Later Life in China: Situating “Long Arm” of Child Physical Maltreatment Within a Family Context by Chengming Han, Tirth Bhatta, Eva Kahana, Boaz Kahana, Brian Gran and Nan Zhou in The International Journal of Aging and Human Development
ИЗУЧЕНИЕ НОВЫХ СОРТОВ КОРМОВОГО СОРГО В УСЛОВИЯХ СЕВЕРНОГО ПРИКАСПИЯ
Creators: name: БУЛАХТИНА Г.К., КУДРЯШОВ А.В.
Publisher: name: ФГБНУ "Прикаспийский НИИ аридного земледелия"
Year: 2018

description: Многолетнее сорго - крупнотравный вид кормовых культур силосного направления для использования в системе зеленого конвейера, на сено и травяную муку. В 2017 году на опытных участках Прикаспийского НИИ аридного земледелия были проведены первые посевы двух сортов этой культуры «Караван» и «Травинка», результаты которых отражены в статье.
Wikiprovenance: Are There Enough References To Every (Known) Fact On Wikidata?
Creators: name: Samuel, John
Publisher: name: Zenodo
Year: 2018

description: In a collaborative website like Wikidata, contributors add statements about an item like a person, a scientific subject, a historical place etc. Each of these statements need to be backed by a reference. Yet a large number of statements are added without references. Even well-described items (i.e., the items with a lot of statements) like Douglas Adams, Albert Einstein do not have references on all these facts. During the past few years, there has been a lot of focus on increasing the number of statements of items usually referred to as the item completion efforts. Yet, the references to statements cannot be undermined. That being said, it is equally important to understand the use of external identifiers and links to existing multilingual Wikimedia projects for these items. Since many of these sources also contain a large number of references. Both contributors and users need to get an overview on the reference statistics. With WikiProvenance, the goal is to understand and delve into details of the usage of references, the links to external sources in an open and transparent manner.
Architecture independent massive parallelization of Divide-and-Conquer algorithms
Creators: name: Achatz, Klaus
name: Schulte, Wolfram
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: DDC 004 / Data processing & computer science
subject: Parallel processing: Electronic computers
subject: Automatische Parallelisierung
subject: Divide-and-conquer-Verfahren

description: N/A
From descriptive specifications to operational ones: a powerful transformation rule, its applications and variants
Creators: name: Achatz, Klaus
name: Partsch, Helmut
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: DDC 004 / Data processing & computer science
subject: Set functions
subject: Mengenwertige Funktion

description: This paper introduces, discusses and proves a transformation rule to convert specification of set-valued functions defined by set comprehension into functional implementations. Variants of the rule for specifications involving existential quantification and arbitrary choice are presented and illustrated by representative examples.
Initial evaluation of the concept-2 rowing ergometer's accuracy using a motorized test rig
Creators: name: Treff, Gunnar
name: Mentz, Lennart
name: Mayer, Benjamin
name: Winkert, Kay
name: Engleder, Thomas
name: Steinacker, Jürgen M.
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: automated testing
subject: validity
subject: power output
subject: home-based training
subject: VARIABILITY
subject: AGREEMENT
subject: DDC 610 / Medicine & health
subject: Automated vehicles
subject: Indoor rowing
subject: Performance
subject: Gültigkeit
subject: Variabilität

description: Introduction The Concept 2 (C2) rowing ergometer is used worldwide for home-based training, official competitions, and performance assessment in sports and science. Previous studies reported a disparate underestimation of mechanical power output positively related to an unclearly defined stroke variability. The aim of this study was to quantify the accuracy of the C2 while controlling for the potentially influencing variables of the rowing stroke by using a test rig for air-braked rowing ergometers and thus excluding biological variability. Methods A unique motorized test rig for rowing ergometers was employed. Accuracy was assessed as the difference in mechanical power output between C2 and a reference system during steady (i.e., minimal variations of stroke power within a series of 50 spacemark, no -strokes) and unsteady simulated rowing (i.e., persistent variations during measurement series) while manipulating the stroke variables shape, force, or rate. Results During steady simulated rowing, differences between C2 and the reference system ranged 2.9–4.3%. Differences were not significantly affected by stroke shapes (P = 0.153), but by stroke rates ranging 22–28 min−1 (P < 0.001). During unsteady simulated rowing with alterations of stroke force and rate, mean differences of 2.5–3.9% were similar as during steady simulated rowing, but the random error increased up to 18-fold. C2 underestimated mechanical power output of the first five strokes by 10–70%. Their exclusion reduced mean differences to 0.2–1.9%. Conclusion Due to the enormous underestimation of the start strokes, the nominal accuracy of the C2 depends on the total number of strokes considered. It ranges 0.2–1.9%, once the flywheel has been sufficiently accelerated. Inaccuracy increases with uneven rowing, but the stroke shape has a marginal impact. Hence, rowers should row as even as possible and prefer higher stroke rates to optimize C2 readings. We recommend external reference systems for scientific and high-performance assessments, especially for short tests designs where the start strokes will have a major impact.
Additional file 1 of Quantitative and qualitative condylar changes following stabilization splint therapy in patients with temporomandibular joint disorders with and without skeletal lateral mandibular asymmetry: a cone beam computed tomographic study
Creators: name: Musa, Mazen
name: Awad, Riham
name: Izeldin, Salma
name: Zhao, Yunshan
name: Wu, Hao
name: Wang, Lu
name: Al-hadad, Saba Ahmed
name: Saif, Bdr Sultan
name: Ahmed, Madiha Mohammed Saleh
name: Chen, Xi
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Supplementary Material 1: Shows the quantitative and qualitative TMJ landmarks definition
O DIREITO FUNDAMENTAL AO MEIO AMBIENTE  ECOLOGICAMENTE EQUILIBRADO E A EDUCAÇÃO  AMBIENTAL NO BRASIL
Creators: name: Ivy de Souza Abreu
name: Luisa Cortat Simonetti Gonçalves
Publisher: name: Zenodo
Year: 2013

description: RESUMEN: Este artículo se propone a analizar la educación ambiental en el contexto de garantía al derecho fundamental al medio ambiente ecológicamente equilibrado. Para eso, son discutidos el derecho fundamental al medio ambiente equilibrado, la temática ambiental en la Constitución brasileña de 1988 y el principio de la educación ambiental. La conciencia ecológica derivada de la Educación ambiental posibilita a los individuos un actuar reflexivo, ético y activo para la transformación de la realidad destructiva del medio natural, construyendo la ciudadanía ambiental y efectuando los valores y principios de conservación del ambiente expresos en la Constitución de 1988. PALABRAS CLAVE: educación ambiental, medio ambiente ecológicamente equilibrado, derecho fundamental.
Additional file 2 of Quantitative and qualitative condylar changes following stabilization splint therapy in patients with temporomandibular joint disorders with and without skeletal lateral mandibular asymmetry: a cone beam computed tomographic study
Creators: name: Musa, Mazen
name: Awad, Riham
name: Izeldin, Salma
name: Zhao, Yunshan
name: Wu, Hao
name: Wang, Lu
name: Al-hadad, Saba Ahmed
name: Saif, Bdr Sultan
name: Ahmed, Madiha Mohammed Saleh
name: Chen, Xi
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Supplementary Material 2: The intra-class correlation coefficient (ICC) results for intra- and inter-observer agreement of TMJ measurements
Fatal Puumala Hantavirus infection in a patient with common variable immunodeficiency (CVID)
Creators: name: Steininger, Philipp
name: Herbst, Larissa
name: Bihlmaier, Karl
name: Willam, Carsten
name: Körper, Sixten
name: Schrezenmeier, Hubert
name: Klüter, Harald
name: Pfister, Frederick
name: Amann, Kerstin
name: Weiss, Sabrina
name: Krüger, Detlev H.
name: Zimmermann, Robert
name: Korn, Klaus
name: Hofmann, Jörg
name: Harrer, Thomas
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: Puumala hantavirus
subject: common variable immunodeficiency
subject: convalescent plasma
subject: DDC 610 / Medicine & health
subject: Hantavirus infections
subject: Encephalitis
subject: Immunity
subject: Ribavirin
subject: Antibodies, Viral
subject: Plasma
subject: Hanta-Virus
subject: Immunität
subject: Ribavirin
subject: Antikörper
subject: Blutplasma

description: Puumala hantavirus (PUUV) infections usually show a mild or moderate clinical course, but may sometimes also lead to life-threatening disease. Here, we report on a 60-year-old female patient with common variable immunodeficiency (CVID) who developed a fatal PUUV infection with persistent renal failure, thrombocytopenia, and CNS infection with impaired consciousness and tetraparesis. Hantavirus-specific antibodies could not be detected due to the humoral immunodeficiency. Diagnosis and virological monitoring were based on the quantitative detection of PUUV RNA in blood, cerebrospinal fluid, bronchial lavage, and urine, where viral RNA was found over an unusually extended period of one month. Due to clinical deterioration and virus persistence, treatment with ribavirin was initiated. Additionally, fresh frozen plasma (FFP) from convalescent donors with a history of PUUV infection was administered. Despite viral clearance, the clinical condition of the patient did not improve and the patient died on day 81 of hospitalization. This case underlines the importance of the humoral immune response for the course of PUUV disease and illustrates the need for PCR-based virus diagnostics in those patients. Due to its potential antiviral activity, convalescent plasma should be considered in the therapy of severe hantavirus diseases.
Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids
Creators: name: Liberta, Falk
name: Lörch, Sarah
name: Rennegarbege, Matthies
name: Schierhorn, Angelika
name: Westermark, Per
name: Westermark, Gunilla T.
name: Hazenberg, Bouke P. C.
name: Grigorieff, Nikolaus
name: Fändrich, Marcus
name: Schmidt, Matthias
Publisher: name: Universität Ulm
Year: 2019
Subjects: subject: Cryoelectron microscopy
subject: Protein aggregation
subject: Structural biology
subject: DDC 570 / Life sciences
subject: Prions
subject: Protein folding
subject: Prion
subject: Proteinfaltung
subject: Strukturbiologie

description: Systemic AA amyloidosis is a worldwide occurring protein misfolding disease of humans and animals. It arises from the formation of amyloid fibrils from the acute phase protein serum amyloid A. Here, we report the purification and electron cryo-microscopy analysis of amyloid fibrils from a mouse and a human patient with systemic AA amyloidosis. The obtained resolutions are 3.0 Å and 2.7 Å for the murine and human fibril, respectively. The two fibrils differ in fundamental properties, such as presence of right-hand or left-hand twisted cross-β sheets and overall fold of the fibril proteins. Yet, both proteins adopt highly similar β-arch conformations within the N-terminal ~21 residues. Our data demonstrate the importance of the fibril protein N-terminus for the stability of the analyzed amyloid fibril morphologies and suggest strategies of combating this disease by interfering with specific fibril polymorphs.
Additional file 3 of LDLR c.415G > A causes familial hypercholesterolemia by weakening LDLR binding to LDL
Creators: name: Wang, Kaihan
name: Hu, Tingting
name: Tai, Mengmeng
name: Shen, Yan
name: Chai, Haocheng
name: Lin, Shaoyi
name: Chen, Xiaomin
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Supplementary Material 3: The certificate of language editing
Additional file 4 of LDLR c.415G > A causes familial hypercholesterolemia by weakening LDLR binding to LDL
Creators: name: Wang, Kaihan
name: Hu, Tingting
name: Tai, Mengmeng
name: Shen, Yan
name: Chai, Haocheng
name: Lin, Shaoyi
name: Chen, Xiaomin
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Supplementary Material 4: The proof report of the overall similarity index
sj-docx-1-ras-10.1177_00208523221126860 - Supplemental material for Corruption risk analysis in local public procurement: a look at the Àrea Metropolitana de Barcelona
Creators: name: Díaz, Javier Miranzo
name: Martinez, Agustí Cerrillo i
name: Caldés, Ramon Galindo
name: Carranza, Judith Castro
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 160607 International Relations
subject: FOS: Political science
subject: 160509 Public Administration

description: Supplemental material, sj-docx-1-ras-10.1177_00208523221126860 for Corruption risk analysis in local public procurement: a look at the Àrea Metropolitana de Barcelona by Javier Miranzo Díaz, Agustí Cerrillo i Martinez, Ramon Galindo Caldés and Judith Castro Carranza in International Review of Administrative Sciences
sj-docx-2-nnr-10.1177_15459683221131791 – Supplemental material for Motor Cognitive Dual-Task Testing to Predict Future Falls in Multiple Sclerosis: A Systematic Review
Creators: name: Abou, Libak
name: Peters, Joseph
name: Fritz, Nora E.
name: Sosnoff, Jacob J.
name: Kratz, Anna L.
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: Neuroscience

description: Supplemental material, sj-docx-2-nnr-10.1177_15459683221131791 for Motor Cognitive Dual-Task Testing to Predict Future Falls in Multiple Sclerosis: A Systematic Review by Libak Abou, Joseph Peters, Nora E. Fritz, Jacob J. Sosnoff and Anna L. Kratz in Neurorehabilitation and Neural Repair
sj-docx-1-jop-10.1177_02698811221131989 – Supplemental material for Belief changes associated with psychedelic use
Creators: name: Nayak, Sandeep M.
name: Singh, Manvir
name: Yaden, David B.
name: Griffiths, Roland R.
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)

description: Supplemental material, sj-docx-1-jop-10.1177_02698811221131989 for Belief changes associated with psychedelic use by Sandeep M. Nayak, Manvir Singh, David B. Yaden and Roland R. Griffiths in Journal of Psychopharmacology
Performance analysis of a hybrid agent for quantum-accessible reinforcement learning
Creators: name: Hamann, Arne
name: Wölk, Sabine
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: quantum reinforcement learning
subject: amplitude amplification
subject: hybrid quantum–classical algorithm
subject: quantum search
subject: DDC 530 / Physics
subject: DDC 620 / Engineering & allied operations
subject: Reinforcement learning
subject: Bestärkendes Lernen (Künstliche Intelligenz)

description: AbstractIn the last decade quantum machine learning has provided fascinating and fundamental improvements to supervised, unsupervised and reinforcement learning (RL). In RL, a so-called agent is challenged to solve a task given by some environment. The agent learns to solve the task by exploring the environment and exploiting the rewards it gets from the environment. For some classical task environments, an analogue quantum environment can be constructed which allows to find rewards quadratically faster by applying quantum algorithms. In this paper, we analytically analyze the behavior of a hybrid agent which combines this quadratic speedup in exploration with the policy update of a classical agent. This leads to a faster learning of the hybrid agent compared to the classical agent. We demonstrate that if the classical agent needs on average ⟨J⟩ rewards and ⟨T⟩cl epochs to learn how to solve the task, the hybrid agent will take ⟨T⟩q⩽αsαo⟨T⟩cl⟨J⟩ epochs on average. Here, α s and α o denote constants depending on details of the quantum search and are independent of the problem size. Additionally, we prove that if the environment allows for maximally α o k max sequential coherent interactions, e.g. due to noise effects, an improvement given by ⟨T⟩q ≈ α o ⟨T⟩cl/(4k max) is still possible.
sj-docx-3-mde-10.1177_23821205231221950 - Supplemental material for Interprofessional Active Learning for Chronic Pain: Transforming Student Learning From Recall to Application
Creators: name: Helms, Jeb
name: Frankart, Laura
name: Bradner, Melissa
name: Ebersole, Jonathan
name: Regan, Beck
name: Crouch, Taylor
Publisher: name: SAGE Journals
Year: 2023
Subjects: Education

description: Supplemental material, sj-docx-3-mde-10.1177_23821205231221950 for Interprofessional Active Learning for Chronic Pain: Transforming Student Learning From Recall to Application by Jeb Helms, Laura Frankart, Melissa Bradner, Jonathan Ebersole, Beck Regan and Taylor Crouch in Journal of Medical Education and Curricular Development
sj-docx-1-cll-10.1177_09636897231221887 – Supplemental material for Relapsed/Refractory Peripheral T-Cell Lymphoma-Associated Hemophagocytic Lymphohistiocytosis With UNC13D and CD27 Germline Mutations
Creators: name: Yang, Tingting
name: Chen, Rongrong
name: Zhang, Mingming
name: Jing, Ruirui
name: Geng, Jia
name: Wei, Guoqing
name: Luo, Yi
name: Xiao, Pingnan
name: Hong, Ruimin
name: Feng, Jingjing
name: Fu, Shan
name: Zhao, Houli
name: Cui, Jiazhen
name: Huang, Simao
name: Huang, He
name: Hu, Yongxian
Publisher: name: SAGE Journals
Year: 2024
Subjects: Medicine
Cell Biology

description: Supplemental material, sj-docx-1-cll-10.1177_09636897231221887 for Relapsed/Refractory Peripheral T-Cell Lymphoma-Associated Hemophagocytic Lymphohistiocytosis With UNC13D and CD27 Germline Mutations by Tingting Yang, Rongrong Chen, Mingming Zhang, Ruirui Jing, Jia Geng, Guoqing Wei, Yi Luo, Pingnan Xiao, Ruimin Hong, Jingjing Feng, Shan Fu, Houli Zhao, Jiazhen Cui, Simao Huang, He Huang and Yongxian Hu in Cell Transplantation
Safety and efficacy of obinutuzumab alone or with chemotherapy in previously untreated or relapsed/refractory chronic lymphocytic leukaemia patients: Final analysis of the Phase IIIb GREEN study
Creators: name: Stilgenbauer, Stephan
name: Bosch, Francesc
name: Ilhan, Osman
name: Kisro, Jens
name: Mahé, Béatrice
name: Mikuskova, Eva
name: Osmanov, Dzhelil
name: Reda, Gianluigi
name: Robinson, Sue
name: Tausch, Eugen
name: Turgut, Mehmet
name: Wójtowicz, Marcin
name: Böttcher, Sebastian
name: Perretti, Thomas
name: Trask, Peter
name: Van Hoef, Marlies
name: Leblond, Véronique
name: Foà, Robin
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Obinutuzumab
subject: chronic lymphocytic leukaemia
subject: IGHV
subject: minimal residual disease
subject: DDC 610 / Medicine & health
subject: Antibodies, Monoclonal, Humanized; Therapeutic use
subject: Leukemia, Lymphoid; Drug therapy
subject: Neoplasm, Residual
subject: Safety
subject: Chronisch-lymphatische Leukämie
subject: Molekulartherapie
subject: Chemotherapie

description: Summary The manageable toxicity profile of obinutuzumab (GA101; G) alone or with chemotherapy in first‐line (1L; fit and non‐fit) and relapsed/refractory (R/R) patients with chronic lymphocytic leukaemia (CLL) was established in the primary analysis of the Phase IIIb GREEN trial (Clinicaltrials.gov: NCT01905943). The final analysis (cut‐off, 31 January 2019) is reported here. Patients received G (1000 mg) alone (G‐mono; fit and non‐fit patients) or with chemotherapy [fludarabine and cyclophosphamide (FC; fit patients); chlorambucil (non‐fit patients); bendamustine (any patient)]. Study endpoints were safety (primary) and efficacy (secondary). Subgroup analyses were performed on prognostic biomarkers in 1L CLL. Overall, 630 patients received 1L and 341 received R/R CLL treatment. At the final analysis, no new safety signals were observed [Grade ≥ 3 adverse events (AEs): 1L 82·7%, R/R 84·5%; serious AEs: 1L 58·1%, R/R 62·5%]. Neutropenia (1L 50·5%, R/R 53·4%) and thrombocytopenia (1L 14·6%, R/R 19·1%) were the most common Grade 3–5 AEs. G‐mono‐, G‐bendamustine and G‐FC‐treated patients with unmutated immunoglobulin heavy chain trended towards shorter progression‐free survival. Achievement of minimal residual disease negativity was greatest in 1L patients treated with G‐FC. In this final analysis of the GREEN trial, the safety profile of G was consistent with current risk management strategies. Biomarker analyses supported efficacy in the specific subgroups.
Virgin and the temptress: scintillae
Creators: name: Dinas, Heather
Publisher: name: RMIT University
Year: 2024

description: 'The virgin, the temptress and the godess' is a visual exploration of love, longing and beauty from the carnal though to the sublime. The narrative of the research has several subtexts: one that explores female archetypes, the muse as figurative source of inspiration and also beauty as a transcendental catalyst. I have sought to represent a comprehensive vision of the female muse that embraces both the spiritual and the sensual and explores the duality of corporeal and metaphysical yearning. This is done through photographic imagery; the journey that it evokes is an interior landscape that takes place in the purgatory that is longing and ascends to a sublime state of stillness and peace through the experience of the divine.
Energy balanced sensor node organisation for maximising network lifetime
Creators: name: Sakib, Kazi Muheymin-Us
Publisher: name: RMIT University
Year: 2024

description: Recent advances in Micro-Electro-Mechanical Systems (MEMS) and low-power short-range radios have enabled rapid development of wireless sensor networks. Future sensor networks are anticipated to include hundreds or thousands of these devices in many applications, such as capturing multimedia content for surveillance, structural health monitoring, tracking of accidental chemical leaks, machine failures, earthquakes and intrusion detection.

With the increase of sensor applications, a number of challenging problems related to the network protocol design has emerged - the most important ones relating to energy efficiency and lifetime maximisation. Techniques devised for sensor networks should deal with a large number of sensors distributed in the field. Wireless sensor nodes are deployed with limited energy reserves, so the networks should operate with minimum energy overhead. In fact, the network should take into account not only individual node's energy efficiency but also consider the global picture, because surviving nodes' energy reserves in a failed network are wasted energy.

This thesis examines a node organisation technique to deal with the above challenges. The focus is on improving network lifetime via organising the nodes in a distributed and energy efficient manner. The main goal is lowering wasted energy via energy balancing and exploiting node redundancy in case of node failure.

In particular, this thesis proposes Energy Balanced Clustering (EBC) method for node self-organisation where network tasks (such as data aggregation and data forwarding) are shifted to high-energy neighbours to reduce the energy consumption of low energy nodes. After showing how to extend network lifetime by energy balanced node organisation, the effect of redundant node deployments on network lifetime is addressed. Redundant nodes consume energy by performing unnecessary tasks so a method called Self-Calculated Redundancy Check (SCRC) is proposed to deactivate redundant nodes. A deactivated redundant node can be used as a replacement for a failed node. The Asynchronous Failed Sensor node Detection (AFSD) proposed in this thesis uses the data packets exchanged between neighbours to identify failed neighbours. To restore coverage for network holes caused by failed nodes, policies are given for re-activating redundant nodes.

Detailed analytical analysis and simulation of the proposed methods demonstrate that by taking into account energy balancing, eliminating redundant tasks and replacing failed nodes sensor network lifetime can significantly be improved.
Scale in remote sensing and its impact on landscape ecology
Creators: name: Lechner, Alex
Publisher: name: RMIT University
Year: 2024

description: The use of remotely sensed derived thematic data has become ubiquitous in landscape ecology. Remote sensing data has the potential to describe broad scale landscape patterns and relate them to ecological processes such as species persistence and distribution. However, these datasets are being used without considering the spatial uncertainty that is ever present in remote sensing data. Maps derived from remote sensing data will vary in the extent, patchiness and accuracy of their landcover classes predominantly due to the inter-relationships of a number of scale dependent factors such as pixel size, minimum mappable unit and categorical resolution. Furthermore, the effect of these factors on landcover classification is more pronounced in fragmented environments which are spatially complex, with habitat patches varying in size from roadside reserves (~10m2) to large vegetation remnants contained within national parks (100km2).

This thesis investigated the interaction and the relative importance of scale dependent factors on the characterisation of landscape pattern and ecological analysis using real and synthetic landcover data and simulated species-environment models. Several key findings emerged from this research. Firstly, it found that mapping error was highest when the scale of the feature and the raster grid coincided. Ecologically important landscape elements such as small and linear vegetation patches of similar scales to the raster grid had lower classification accuracies, and were less likely to be extracted than larger more compact features. Secondly, this thesis showed that at coarser scales, subtle levels of patchiness declined. Small patches either aggregated into larger patches or completely disappeared. Thirdly, it demonstrated that the ability to identify the scale at which a species interacts with the environment, using multi-scale species-environment models is affected by the scale of the remote sensing data. In conclusion, this thesis quantified the impact of scale on the classification of landcover maps and demonstrated how spatial uncertainty in the characterisation of landscape pattern can impact on ecological analysis. Without the incorporation of uncertainty arising from scale, ecological analyses using remote sensing data will continue to produce results with unquantified uncertainties, which may result in poor and/or ineffective management decisions.