title: Ð¤Ð¾ÑÐ¾ÑÐ¸Ð·Ð¸ÑÐµÑÐºÐ¸Ðµ ÑÐ²Ð¾Ð¹ÑÑÐ²Ð° ÑÐ¾ÑÐ¾ÑÐµÐ½ÑÐ¸Ð±Ð¸Ð»Ð¸Ð·Ð°ÑÐ¾ÑÐ° Ð Ð°Ð´Ð°Ñ Ð»Ð¾ÑÐ¸Ð½ Ð¸ Ð³ÐµÐ½ÐµÑÐ°ÑÐ¸Ñ ÑÐ¸Ð½Ð³Ð»ÐµÑÐ½Ð¾Ð³Ð¾ ÐºÐ¸ÑÐ»Ð¾ÑÐ¾Ð´Ð° Ð² ÑÐ°ÑÑÐ²Ð¾ÑÐµ PBS Ð² Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÐ¸ Ð¾Ñ ÑÐµÐ¼Ð¿ÐµÑÐ°ÑÑÑÑ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Photophysical properties of the photosensitizer Radachlorin and the generation of singlet oxygen in a PBS solution depending on temperature
Creators: name: Ð§ÑÐ´Ð°ÐºÐ¾Ð², ÐÐ¸ÑÐ¸Ð»Ð»
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: ÑÐ°Ð´Ð°Ñ Ð»Ð¾ÑÐ¸Ð½
ÑÐ¾ÑÐ¾ÑÐµÐ½ÑÐ¸Ð±Ð¸Ð»Ð¸Ð·Ð°ÑÐ¾ÑÑ Ð²ÑÐµÐ¼Ñ-ÑÐ°Ð·ÑÐµÑÐµÐ½Ð½Ð°Ñ ÑÐ¿ÐµÐºÑÑÐ¾ÑÐºÐ¾Ð¿Ð¸Ñ
Ð²ÑÐµÐ¼Ñ Ð¶Ð¸Ð·Ð½Ð¸ ÑÐ¾ÑÑÐ¾ÑÐµÑÑÐµÐ½ÑÐ¸Ð¸
ÑÐ¸Ð½Ð³Ð»ÐµÑÐ½ÑÐ¹ ÐºÐ¸ÑÐ»Ð¾ÑÐ¾Ð´
radachlorin
laser pulses
photosensitizers
luminescence lifetimes
singlet oxygen

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description: Photodynamic therapy (PDT) is one of the modern actively developing methods of cancer treatment. The essence of this method is as follows: photosensitizer is injected into the body, which selectively accumulates in malignant cells, then the affected area is irradiated with a laser with a wavelength corresponding to the maximum absorption of PS and the formation of singlet oxygen, which induces cell death. There are a number of questions related to photosensitizers: what mechanisms of formation of reactive oxygen species occur when photosensitizers are excited, where does the photosensitizer accumulate in the cell, how effective is its accumulation in a cancer cell, how well is singlet oxygen generated at the temperature of a living organism? The study of the photophysical properties of photosensitizers may provide an answer to some of the above questions. The main parameters of Radachlorin phosphorescence, such as the generation and attenuation times of phosphorescence depending on temperature in an aqueous solution of PBS, were experimentally studied. The kinetics of Radachlorin luminescence under excitation in the absorption band with a wavelength of 405 nm was studied. Luminescence was recorded using the technique of counting single photons with time correlation. The review of the literature on the luminescence of biological molecules, the methodology of the experiment, the processing of experimental data, as well as the analysis of the results obtained are presented.