Additional file 1 of Clinical trial results in context: comparison of baseline characteristics and outcomes of 38,510 RECOVERY trial participants versus a reference population of 346,271 people hospitalised with COVID-19 in England
Creators: name: Pessoa-Amorim, Guilherme
name: Goldacre, Raphael
name: Crichton, Charles
name: Stevens, Will
name: Nunn, Michelle
name: King, Andy
name: Murray, Dave
name: Welsh, Richard
name: Pinches, Heather
name: Rees, Andrew
name: Morris, Eva J. A.
name: Landray, Martin J.
name: Haynes, Richard
name: Horby, Peter
name: Wallendszus, Karl
name: Peto, Leon
name: Campbell, Mark
name: Harper, Charlie
name: Mafham, Marion
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Additional file 1: Annex I. Supplementary methods. Annex II. Supplementary tables and figures. Supplementary Figure S1. Age and sex representativeness of RECOVERY in comparison with the reference population. Supplementary Figure S2. Ethnicity over time in the RECOVERY cohort in comparison with the reference population, by age. Supplementary Figure S3. Deprivation over time in the RECOVERY cohort in comparison with the reference population, by age. Supplementary Figure S4. Charlson Comorbidity Score (excluding age) and Hospital Frailty Risk Score in the RECOVERY cohort and the reference population, by age groups. Supplementary Figure S5. Hospital Frailty Risk Score over time in the RECOVERY cohort and the reference population, by age groups. Supplementary Figure S6. Prevalence of select comorbidities in the RECOVERY cohort and reference population, by age groups. Supplementary Figure S7. 28-day mortality in the RECOVERY HES and All-England HES populations (stratified by age and sex). Supplementary Figure S8. 28-day mortality over time in RECOVERY and the reference population (by age groups). Supplementary Figure S9. Mortality rates over time in RECOVERY and the reference population, by age, comorbidity, and frailty. Supplementary Table S1. Baseline characteristics of the RECOVERY population recruited in the UK, grouped by nation (using data from the case report form only, except where stated). Supplementary Table S2. Baseline characteristics of the RECOVERY population recruited in England, grouped by HES linkage status (using data from the case report form only, except where stated). Supplementary Table S3. Number of individuals included in RECOVERY versus reference population over time, by age groups. Supplementary Table S4. 28-day mortality along time in the RECOVERY HES and All-England HES cohorts (split by age groups). Supplementary Table S5. Cross-coding of COVID-19 in HES and SGSS data within the RECOVERY population. Supplementary Table S6. Cross-coding of COVID-19 in HES (disaggregated across different ICD-10 codes) and SGSS data within the RECOVERY population. Supplementary Table S7. IMV coding cross tabulation (HES vs CRF)—15 days before randomisation. Supplementary Table S8. IMV coding cross tabulation (HES vs CRF)—30 days before randomisation. Supplementary Table S9. NIV coding cross tabulation (HES vs CRF)—15 days before randomisation. Supplementary Table S10. NIV coding cross tabulation (HES vs CRF)—30 days before randomisation. Annex III. Cross-coding of COVID-19 coding in Hospital Episode Statistics versus testing data in SGSS within the RECOVERY population. Annex IV. Cross-coding of invasive and non-invasive mechanical ventilation in the RECOVERY case report form versus Hospital Episode Statistics data