cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Robust Gait Recognition by Integrating Inertial and RGBD Sensors
Creators: name: Zou, Qin
name: Ni, Lihao
name: Wang, Qian
name: Li, Qingquan
name: Wang, Song
Publisher: name: arXiv
Year: 2016
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Gait has been considered as a promising and unique biometric for person identification. Traditionally, gait data are collected using either color sensors, such as a CCD camera, depth sensors, such as a Microsoft Kinect, or inertial sensors, such as an accelerometer. However, a single type of sensors may only capture part of the dynamic gait features and make the gait recognition sensitive to complex covariate conditions, leading to fragile gait-based person identification systems. In this paper, we propose to combine all three types of sensors for gait data collection and gait recognition, which can be used for important identification applications, such as identity recognition to access a restricted building or area. We propose two new algorithms, namely EigenGait and TrajGait, to extract gait features from the inertial data and the RGBD (color and depth) data, respectively. Specifically, EigenGait extracts general gait dynamics from the accelerometer readings in the eigenspace and TrajGait extracts more detailed sub-dynamics by analyzing 3D dense trajectories. Finally, both extracted features are fed into a supervised classifier for gait recognition and person identification. Experiments on 50 subjects, with comparisons to several other state-of-the-art gait-recognition approaches, show that the proposed approach can achieve higher recognition accuracy and robustness.
Novel inhibitors with sulfamethazine backbone: synthesis and biological study of multi-target cholinesterases and α-glucosidase inhibitors
Creators: name: Türkeş, Cüneyt
name: Akocak, Suleyman
name: Işık, Mesut
name: Lolak, Nebih
name: Taslimi, Parham
name: Durgun, Mustafa
name: Gülçin, İlhami
name: Budak, Yakup
name: Beydemir, Şükrü
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 60506 Virology

description: The underlying cause of many metabolic diseases is abnormal changes in enzyme activity in metabolism. Inhibition of metabolic enzymes such as cholinesterases (ChEs; acetylcholinesterase, AChE and butyrylcholinesterase, BChE) and α-glucosidase (α-GLY) is one of the accepted approaches in the treatment of Alzheimer’s disease (AD) and diabetes mellitus (DM). Here we reported an investigation of a new series of novel ureido-substituted derivatives with sulfamethazine backbone (2a-f) for the inhibition of AChE, BChE, and α-GLY. All the derivatives demonstrated activity in nanomolar levels as AChE, BChE, and α-GLY inhibitors with KI values in the range of 56.07–204.95 nM, 38.05–147.04 nM, and 12.80–79.22 nM, respectively. Among the many strong N-(4,6-dimethylpyrimidin-2-yl)-4-(3-substitutedphenylureido) benzenesulfonamide derivatives (2a-f) detected against ChEs, compound 2c, the 4-fluorophenylureido derivative, demonstrated the most potent inhibition profile towards AChE and BChE. A comprehensive ligand/receptor interaction prediction was performed in silico for the three metabolic enzymes providing molecular docking investigation using Glide XP, MM-GBSA, and ADME-Tox modules. The present research reinforces the rationale behind utilizing inhibitors with sulfamethazine backbone as innovative anticholinergic and antidiabetic agents with a new mechanism of action, submitting propositions for the rational design and synthesis of novel strong inhibitors targeting ChEs and α-GLY. Communicated by Ramaswamy H. Sarma
OBESITY AND METABOLIC SYNDROME: PLASMA LIPOPROTEINS ALTERATIONS
Creators: name: CAMEROTTO, CARLA
Publisher: name: Universit� degli Studi di Milano
Year: 2011

description: Obesity, especially if associated with metabolic syndrome, promotes oxidative stress, a low grade chronic inflammatory state, and modify the composition and function of plasma lipoproteins. Oxidative damage to lipoproteins not only make LDL atherogenic but can also alter HDL reducing their anti-atherogenic properties. The possibility of monitoring the lipid peroxidation of the individual regions of LDL and HDL could lead to more detailed information on the molecular mechanisms that are the basis of the increased risk of cardiovascular diseases observed in obesity and metabolic syndrome. The object of this study was to investigate the susceptibility to peroxidation of plasma and of the hydrophobic core and the surrounding envelope of LDL and HDL in obese male (BMI between 25 and 35 Kg mq) with (SM, n=20)) or without (OB, n =40) metabolic syndrome. The susceptibility of plasma to peroxidation was higher in SM and OB than in normo-weight controls (CT, n=60), but not significant differences were observed between these two obese groups. Also the susceptibility to peroxidation of isolated LDL and HDL was higher in both obese groups than in CT. LDL and HDL in SM presented an higher content of triacylglicerols than the corresponding HDL of OB. Moreover, the hydrophobic core of HDL showed a risk of peroxidation significantly higher in SM than in OB. This last parameter was inversely correlated with the waist to hip ratio, an index of visceral obesity. This last evidence seems to indicate that the increase of inflammation typical of the visceral adipose tissue could be one of the major causes of the higher susceptibility to peroxidation found in the hydrophobic core of HDL. The evaluation of the susceptibility to peroxidation of the core and the envelope of LDL and HDL might contribute to the identification of a subset of patients at increased risk of metabolic and cardiovascular complications. Future ?ad hoc? randomized clinical trials should be designed to address the effects of weight reduction and /or different diet and/or nutritional supplementation on these parameters.
A spatial loss model for small rural catchments
Creators: name: Rajendran, Rajanayagam
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Rational design of hyper-glycosylated human follicle-stimulating hormone analogs (a bioinformatics approach)
Creators: name: Bahadori, Zohreh
name: Shabani, Ali Akbar
name: Minuchehr, Zarrin
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: N-glycosylation is a complex mechanism in which the carbohydrate molecules bind to the Asn amino acid in the N-glycan consensus sequence (AsnXxxThr/Ser sequon, where Xxx is any residue, excluding Pro). Introduction of additional N-linked glycosylation site into proposed location in the protein causes to its hyper-glycosylation and can enhance the protein characteristics to provide promising prospects in treatment. Glycoengineering is a favorably used strategy to design and generate hyper-glycosylated variants. In this research, human follicle-stimulating hormone (HuFSH) was considered to identify appropriate positions for adding novel N-glycan sites. A rational computational strategy was applied to predict functional/structural variations induced through changes in polypeptide chain. We analyzed the amino acid chain of FSH to find out the proper locations to introduce asparagine and/or threonine for creating novel N-glycan positions. This analysis resulted in the recognition of 40 possible N-glycosylation positions, and then the eight adequate ones were chosen for additional investigation. The model validation techniques were used to examine 3-dimensional structures of the chosen mutant proteins. Finally, 2 mutants with a further glycan site were recommended as eligible FSH hyper-glycosylated analogs, which may be regarded for subsequent experimental studies. Our in silico approach may decrease tedious and time-wasting laboratory researches of the mutants. Communicated by Ramaswamy H. Sharma
Type-II surface brightness profiles in edge-on galaxies produced by flares
Creators: name: Borlaff, Alejandro
name: Eliche-Moral, M. Carmen
name: Beckman, John
name: Font, Joan
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Previous numerical studies had apparently ruled out the possibility that flares in galaxy discs could give rise to the apparent breaks in their luminosity profiles when observed edge-on. However the studies have not, until now, analyzed this hypothesis systematically using realistic models for the disc, the flare, and the bulge. We revisit this theme by analyzing a series of models which sample a wide range of observationally based structural parameters for these three components. We have considered realistic distributions of bulge to disc ratios, morphological parameters of bulges and discs, vertical scale heights of discs and their radial gradients defining the flare for different morphological types and stellar mass bins, based on observations. The surface brightness profiles for the face-on and edge-on views of each model were simulated to find out whether the flared disc produces a Type-II break in the disc profile when observed edge-on, and if so under what conditions. Contrary to previous claims, we find that discs with realistic flares can produce significant breaks in discs when observed edge-on. Specifically a flare with the parameters of that of the Milky Way would produce a significant break of the disc at a Rbreak of ~8.6 kpc if observed edge-on. Central bulges have no significant effects on the results. These simulations show that flared discs can explain the existence of many Type-II breaks observed in edge-on galaxies, in a range of galaxies with low-to-intermediate break strength values of -0.25
description: Published in Astronomy & Astrophysics. 5 pages, 5 figures. Language corrections by the journal included in this new version
On the design of controllers to reduce interaction in multichannel electrohydraulic drives
Creators: name: Pannala, Adisesha Sastry
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
The adhesion of thermally sprayed coatings
Creators: name: Ostojic, Peter
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
On the Observation and Simulation of Solar Coronal Twin Jets
Creators: name: Liu, Jiajia
name: Fang, Fang
name: Wang, Yuming
name: McIntosh, Scott W.
name: Fan, Yuhong
name: Zhang, Quanhao
Publisher: name: arXiv
Year: 2016
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present the first observation, analysis and modeling of solar coronal twin jets, which occurred after a preceding jet. Detailed analysis on the kinetics of the preceding jet reveals its blowout-jet nature, which resembles the one studied in Liu et al. 2014. However the erupting process and kinetics of the twin jets appear to be different from the preceding one. In lack of the detailed information on the magnetic fields in the twin jet region, we instead use a numerical simulation using a three-dimensional (3D) MHD model as described in Fang et al. 2014, and find that in the simulation a pair of twin jets form due to reconnection between the ambient open fields and a highly twisted sigmoidal magnetic flux which is the outcome of the further evolution of the magnetic fields following the preceding blowout jet. Based on the similarity between the synthesized and observed emission we propose this mechanism as a possible explanation for the observed twin jets. Combining our observation and simulation, we suggest that with continuous energy transport from the subsurface convection zone into the corona, solar coronal twin jets could be generated in the same fashion addressed above.
description: 7 pages, 5 figures
Exploring transdisciplinary performance and creation in Le corps qui habite en moi for solo flute
Creators: name: Durante, Leticia Maia
name: Mani, Pedro Yugo Sano
Publisher: name: ÍMPAR: Online Journal for Artistic Research
Year: 2023

description: This paper is aimed to clarify the creation of the composition and performance of Le corps qui habite en moi, the result of the collaborative process between two artist-researchers. It is an exploration of our searches as musicians and researchers within the Western Classical Music esthetics, raising questions related to the creativity and the freedom of expression in our environment. We believe that it is necessary to go beyond some barriers and question preconceived ideas within the tradition about what is a concert, a performance and a creative process. Another central question is related to the relation of mind-body in our modern society as well as on the Western Classical Music esthetics, where the player’s body is many times effaced and renegade in the musical performance. Within the field of artistic research, the main objective was the creation of a composition and a transdisciplinary performance that could reveal the expression of a body on stage. From the composition it was created a semi-opened choreography and a series of watercolors that interact with different moments of the composition, creating a narrative elucidating the awaken of the human body as an expressive agent in the performance, as well as the intermodal character of the creative activity. The central part of this paper is the performance presented at the Post-ip Congress of the University of Aveiro in December 2022; therefore, we recommend watching the video before reading the text.
description: ÍMPAR: Online Journal for Artistic Research, vol. 6 n.º 1 (2022): IMPAR Online Journal for artistic research
Economy Wide Impact of Investment in Road Infrastructure in Ethiopia: A Recursive Dynamic Computable General Equilibrium Approach
Creators: name: Bekele, Semen
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2015

description: In current periods Ethiopia has been implementing huge investment in road infrastructure across the country. Despite the significant improvements in road length, accessibility and quality of roads, few researches were conducted on the impacts of investments in road infrastructure on economic growth, household income and consumption growth. These researches were conducted following the partial equilibrium or econometric techniques that lacks to address the interrelated effect in addition to the limitation that some of these studies were done for a specific road sector development programs and or specific areas In this study an attempt has been made to examine economy wide impact of investment in road infrastructure using a recursive dynamic CGE model. The study used an updated version of the 2005/06 EDRI Social Accounting Matrix. Six simulations were considered. While the first three simulations were based on the existing and past Ethiopia policy which considered the average road density growth in the PASDEP period, the average density growth required to reach the middle income level and the average road density growth in the GTP period, the last three simulation were considered as robustness test. Simulations with the CGE model confirm that with increasing availability of road infrastructure, there is a positive growth in the macroeconomic and sectorial indicators (Real GDP, absorption, investment, private consumption, real export, and real import) though the magnitude of the effects is relatively small compared with the high investment costs and the changes varies among the different indicators. Similarly the demand for labor, capital, land and livestock increases with increasing availability of road infrastructure. Income from livestock and land responds better compared to labor and capital as road investment increases. Welfare, measured as real consumption, increases on average and at the disaggregate level for all households. In this case the rural poor benefited more from road investment in terms of earning better income and consumption. Road infrastructure affects the production sectors differently. Manufacturing and capital-intensive activities benefit, while agricultural sectors are less favored, given the relative increase in wages.
TECHNOLOGY READINESS FOR ARTIFICIAL INTELLIGENCE INFLUENCES INDIVIDUAL’S PURCHASING INTENTION ON SOCIAL MEDIA THROUGH TECHNOLOGY ACCEPTANCE MODEL
Creators: name: Watcharapong TUNPORNCHAI
Publisher: name: Asian Administration and Management Review
Year: 2023
Subjects: Technology Readiness Index
Technology Acceptance
Purchasing Intention

description: Asian Administration and Management Review, 6, 1, 27-34
Energy and Economic Growth in Ethiopia: Granger Causality Approach
Creators: name: Wondimaghegn, Mehari
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2011

description: The aim of this paper is to re-examine the causal relationship between energy consumption and economic growth in Ethiopia using annual data from 1981 to 2006, in a multivariate framework by including labor and capital as additional variables. We apply the Granger causality test, variance decomposition analysis and Generalised impulse response analysis in linear multivariate models to evaluate how important is the causal impact of energy consumption on economic growth relative to labor and capital. The results give the evidence of causality running from economic growth to energy consumption. The variance decomposition analysis reveals that energy was no more than a minor contributing factor to output growth and certainly not the most important one when compared to capital and labor. Capital and labor are the most important factors in output growth in Ethiopia.
The measurements of turbulence in tidal currents
Creators: name: Osonphasop, Chusak
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Synthesis, molecular modelling, in vitro and in vivo evaluation of conophylline inspired novel benzyloxy substituted indole glyoxylamides as potent pancreatic lipase inhibitors
Creators: name: C, Sridhar S. N.
name: Sengupta, Pracheta
name: Palawat, Saksham
name: S., Dileep P.
name: George, Ginson
name: Paul, Atish T.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: Pancreatic lipase is a digestive enzyme involved in the hydrolysis of dietary fats. Orlistat, a potent pancreatic lipase inhibitor, is widely prescribed for long-term obesity treatment. Nevertheless, orlistat is reported for severe adverse effects including hepatotoxicity and pancreatitis. In the present study, a novel series of 11 benzyloxy substituted indole glyoxylamides were designed, synthesized and evaluated for in vitro pancreatic lipase inhibitory activity. Three analogues, 10b, 11b and 11c, exhibited potent activity (IC50 ≤ 2.5 µM), with 11b exhibiting a potent IC50 of 1.68 µM comparable to orlistat (IC50 = 0.99 µM). Further, 11b exhibited reversible competitive inhibition with an inhibitory constant value of 0.98 μM. Molecular docking of these analogues was in agreement with in vitro results, wherein the MolDock scores exhibited significant correlation with their inhibitory activity (Pearson’s r = 0.7122). A 50 ns molecular dynamics simulation of 11b-pancreatic lipase complex confirmed the role of extended alkyl interactions along with π-π stacking and π-cation interactions, in stabilizing the ligand (Maximum RMSD ≈ 3 Å) in the active site. Gastro-intestinal absorption and toxicity prediction of the three potent analogues highlighted the suitability of 11b for in vivo experiments. 11b at a dose of 20 mg/kg exhibited anti-obesity efficacy comparable to orlistat (10 mg/kg), wherein the serum triglycerides were found to be 94.95 and 83.85 mg/dL, respectively. Further, faecal triglyceride quantification indicated 11b to act through pancreatic lipase inhibition similar to orlistat. The present study identified a novel pancreatic lipase inhibitory benzyloxy substituted bis(indolyl) glyoxylamide 11b, with promising anti-obesity activity. Communicated by Ramaswamy H. Sarma
Self-consistent double-hybrid density-functional theory using the optimized-effective-potential method
Creators: name: Smiga, Szymon
name: Franck, Odile
name: Mussard, Bastien
name: Buksztel, Adam
name: Grabowski, Ireneusz
name: Luppi, Eleonora
name: Toulouse, Julien
Publisher: name: arXiv
Year: 2016
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: We introduce an orbital-optimized double-hybrid (DH) scheme using the optimized-effective-potential (OEP) method. The orbitals are optimized using a local potential corresponding to the complete exchange-correlation energy expression including the second-order M{ø}ller-Plesset (MP2) correlation contribution. We have implemented a one-parameter version of this OEP-based self-consistent DH scheme using the BLYP density-functional approximation and compared it to the corresponding non-self-consistent DH scheme for calculations on a few closed-shell atoms and molecules. While the OEP-based self-consistency does not provide any improvement for the calculations of ground-state total energies and ionization potentials, it does improve the accuracy of electron affinities and restores the meaning of the LUMO orbital energy as being connected to a neutral excitation energy. Moreover, the OEP-based self-consistent DH scheme provides reasonably accurate exchange-correlation potentials and correlated densities.
description: in The Journal of Chemical Physics, American Institute of Physics, 2016
Cyclic stress-strain and pore pressure behaviour of a soft alluvial clay
Creators: name: Ng, Kok-Kuang
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Economic Valueation of Agro biodiversity and its Determinant in West Gojjam Zone, Amhara Region, Ethiopia: Choice Experiment Approach
Creators: name: Teshager, Mazengia
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2019

description: Environmental resources, such as agro biodiversity has many benefits to human beings. However, absence of markets and the activity of human beings increase the loss of agro-biodiversity. In this case, application of non-market valuation methods and identifying determinant factors of agrobiodiversity have paramount importance. Therefore, this study is conducted to quantify the total economic values and determinant factors of agro-biodiversity in West Gojjam zone of Amhara region. Random parameter logit estimate revealed that farmers WTA for landrace crops, organic farming, and crop species diversity are 549.58, 430, and 228.53 birrs per year per household. To see the effect of decision maker characterstics conditional logit with interaction terms was also evaluated and it shows that age, household size, and education level of farm household are significant factors affecting demand for agro-biodiversity attributes. In addition to valuation, determinant factors of agro-biodiversity were analyzed. The result of both poisson and Tobit model estimates of cereal and horticulture crop diversity, suggests that the sign and magnitudes of the effect of a farm, household, and agro-ecological characteristics accompanied by agriculture policies are different. For instance, age, gender, and household size have an insignificant effect on cereal crop diversity, while they have a significant effect on Horticulture Crop diversity. Moreover, number of plots is an important variable for increasing cereal crop diversity, while it has no significant effect on horticulture crop diversity. The study recommends that to conserve agro biodiversity effctively the government and agriculture organizations should motivate the production of organic farming through price premiums and quick certification of organic crops, expand gene banks to restore lost traditional varieties and motivate farmers to cultivate traditional crops, give training for farmers about agro-biodiversity, improve the efficiency of irrigation water use, and scientifically identify types of crops supported in inter cropping.
Miscibility studies of poly ([epsilon]-Caprolactone)
Creators: name: Chynoweth, poly blends [manuscript] / Kevin Richard
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
In-silico evidences on filarial cystatin as a putative ligand of human TLR4
Creators: name: Das, Nabarun Chandra
name: Gupta, Parth Sarthi Sen
name: Biswal, Satyaranjan
name: Patra, Ritwik
name: Rana, Malay Kumar
name: Mukherjee, Suprabhat
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Computational Biology

description: Cystatin is a small molecular weight immunomodulatory protein of filarial parasite that plays a pivotal role in downregulating the host immune response to prolong the survival of the parasite inside the host body. Hitherto, this protein is familiar as an inhibitor of human proteases. However, growing evidences on the role of cystatin in regulating inflammatory homeostasis prompted us to investigate the molecular reasons behind the explicit anti-inflammatory trait of this protein. We have explored molecular docking and molecular dynamics simulation approaches to explore the interaction of cystatin of Wuchereria bancrofti (causative parasite of human filariasis) with human Toll-like receptors (TLRs). TLRs are the most crucial component of frontline host defence against pathogenic infections including filarial infection. Our in-silico data clearly revealed that cystatin strongly interacts with the extracellular domain of TLR4 (binding energy=-93.5 ± 10 kJ/mol) and this biophysical interaction is mediated by hydrogen bonding and hydrophobic interaction. Molecular dynamics simulation analysis revealed excellent stability of the cystatin-TLR4 complex. Taken together, our data indicated that cystatin appears to be a ligand of TLR4 and we hypothesize that cystatin-TLR4 interaction most likely to play a key role in activating the alternative activation pathways to establish an anti-inflammatory milieu. Thus, the study provokes the development of chemotherapeutics and/or vaccines for targeting the cystatin-TLR4 interaction to disrupt the pathological attributes of human lymphatic filariasis. Our findings are expected to provide a novel dimension to the existing knowledge on filarial immunopathogenesis and it will encourage the scientific communities for experimental validation of the present investigation. Communicated by Ramaswamy H. Sarma
title: Metrologie für die molekulare und zelluläre Medizin
Creators: name: Macdonald, Rainer
name: Neukammer, Jörg
name: John, Manuela
name: Kummrow, Andreas
name: Schädel, Sandra
name: Schulze, Karin
name: Witt, Klaus
name: Marcin, Frankowski
name: Tuchscheerer, Andrej
name: Schmidt, Martin
name: Voigt, Jan
name: Ebert, Bernd
name: Hoffmann, Angelika
name: Rüttinger, Steffen
name: Krämer, Benedikt
name: Roos, Martin
name: Licha, Kai
name: Eberbeck, Dietmar
name: Steinhoff, Uwe
name: Trahms, Lutz
name: Kilian, Wolfgang
name: Seifert, Frank
name: Ittermann, Bernd
Publisher: name: Physikalisch-Technische Bundesanstalt (PTB)
Year: 2014

description: PTB-Mitteilungen. Band 118 (2008), Heft 4, Seite 231 - 277. ISSN 0030-834X
Operating Performance and Capital Structure of Rural Saving and Credit Cooperatives in Ethiopia: Application of Panel Threshold Method
Creators: name: Engida, Melkamu
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2008

description: The main objective of this study was to examine whether operating performances of rural saving and credit cooperatives are under the influence of capital structure inline with loans growth, and to test if threshold relationship exists in these cooperatives of the Amhara, Oromia, SNNP and Tigray regions. A panel data of 92 rural saving and credit cooperatives from 2004 to 2007 was used and threshold regression analysis model developed by Hansen (1999) applied. Further, this study reviews the saving and loan outreach as well as financial performance of rural saving and credit cooperatives using Protection, Effective financial structure, Asset quality, Rates of return and cost, Liquidity and Signs of growth(PEARLS) monitoring system software that developed by World Credit Cooperative Union. The empirical findings depict that capital structures significantly influence rural saving and credit cooperatives. The threshold variables (net worth to loan ratio) have two values 0.11 and 0.01. When the threshold value is between these figures, every unit of growth in loans increases operating performance by 0.10 times, which is not satisfactory. The empirical findings also show that the growth in loans for the rural saving and credit cooperatives in all four regions affects operating performance. In addition, saving and loan outreach performance varies by region. While, Oromia comprises 53% of the rural saving and credit cooperatives, Amhara dominates with small number of savers (14%) but with large number of borrowers (30%). In general, the number of savers to borrowers in Amhara is 3:1, in Tigray 3.2:1, in SNNP 4:1 and in Oromia 23:1. Moreover, the empirical findings of financial performance of rural saving and credit cooperatives using monitoring system software shows that all rural saving and credit cooperatives in the country are not practicing loan loss protection and even solvency is 50% less than the standard.
A critical point in Sr2-xIrO4 and less distorted IrO6 octahedra induced by deep Sr-vacancies
Creators: name: Cheng, Jie
name: Liu, Shengli
name: Li, Bin
name: Wang, Haiyun
name: Wang, Yu
name: Xu, Wei
Publisher: name: arXiv
Year: 2016
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: For the Sr2-xIrO4 system, recent work pointed out the abnormal electronic and magnetic properties around the critical point. Here, to understand Sr-vacancy effect on spin-orbit coupled Mott insulator Sr2IrO4, the electronic structure and local structure distortion for Sr2-xIrO4 system have been investigated by x-ray absorption spectroscopy (XAS). By comparing the intensity of white-line features at the IrL2,3-edge x-ray absorption near-edge spectroscopy (XANES), we observe a sudden rise of the branching ratio in the vicinity of the critical point.Further analysis on theIrL3 -edge extended x-ray absorption fine structure (EXAFS) and calculated data demonstrated that the abrupt enhancement of the branching ratio is intimately related to the less distorted IrO6 octahedra induced by deep Sr-vacancies, which in turn alters the relatively strength of the spin-orbit coupling (SOC) and crystal electric field (CEF)that would dictate the abnormal behavior of electronic and magnetic structure near the critical point.
description: 18 pages, 5 figures. arXiv admin note: text overlap with arXiv:1610.09839
MPEC 2023-L03 : 2023 KN5
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 KN5

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Remark on higher-derivative mechanics with l-conformal Galilei symmetry
Creators: name: Masterov, Ivan
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: Based on the results in [Nucl. Phys. B 866 (2013) 212], we consider a way to construct a higher-derivative mechanical model which possesses the $l$-conformal Galilei symmetry. The dynamical system describes generalized Pais-Uhlenbeck oscillator in the presence of an effective external field.
description: V1: 1+10 pages; V2: 1+10 pages, typos corrected, clarifying remarks included into Section 2, acknowledgements added; the version published in JMP
A large-scale computational screen identifies strong potential inhibitors for disrupting SARS-CoV-2 S-protein and human ACE2 interaction
Creators: name: Singh, Adarsh
name: Dhar, Riddhiman
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: 110309 Infectious Diseases
subject: 60506 Virology

description: SARS-CoV-2 has infected millions of individuals across the globe and has killed over 2.7 million people. Even though vaccines against this virus have recently been introduced, the antibody generated in the process has been reported to decline quickly. This can reduce the efficacy of vaccines over time and can result in re-infections. Thus, drugs that are effective against COVID-19 can provide a second line of defence and can prevent occurrence of the severe form of the disease. The interaction between SARS-CoV2 S-protein and human ACE2 (hACE2) is essential for the infection of the virus. Thus, drugs that block this interaction could potentially inhibit SARS-CoV-2 infection into the host cells. To identify such drugs, we first analyzed the recently published crystal structure of S-protein-hACE2 complex and identified essential residues of both S-protein and hACE2 for this interaction. We used this knowledge to virtually dock a drug library containing 4115 drug molecules against S-protein for repurposing drugs that could inhibit binding of S-protein to hACE2. We identified several potential inhibitors based on their docking scores, pharmacological effects and ability to block residues of S protein required for interaction with hACE2. The top inhibitors included drugs used for the treatment of hepatitis C (velpatasvir, pibrentasvir) as well as several vitamin D derivatives. Several molecules obtained from our screen already have good experimental support in published literature. Thus, we believe that our results will facilitate the discovery of an effective drug against COVID-19. Communicated by Ramaswamy H. Sarma
The thermodynamic meaning of local temperature of nonequilibrium open quantum systems
Creators: name: Ye, LvZhou
name: Zheng, Xiao
name: Yan, YiJing
name: Di Ventra, Massimiliano
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Measuring the local temperature of nanoscale systems out of equilibrium has emerged as a new tool to study local heating effects and other local thermal properties of systems driven by external fields. Although various experimental protocols and theoretical definitions have been proposed to determine the local temperature, the thermodynamic meaning of the measured or defined quantities remains unclear. By performing analytical and numerical analysis of bias-driven quantum dot systems both in the noninteracting and strongly-correlated regimes, we elucidate the underlying physical meaning of local temperature as determined by two definitions: the zero-current condition that is widely used but not measurable, and the minimal-perturbation condition that is experimentally realizable. We show that, unlike the zero-current one, the local temperature determined by the minimalperturbation protocol establishes a quantitative correspondence between the nonequilibrium system of interest and a reference equilibrium system, provided the probed system observable and the related electronic excitations are fully local. The quantitative correspondence thus allows the well-established thermodynamic concept to be extended to nonequilibrium situations.
description: 15 pages, 5 figures
Pseudo steady-state non-Gaussian EPR-steering of massive particles in pumped and damped Bose-Hubbard dimers
Creators: name: Olsen, M. K.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We propose and analyse a pumped Bose-Hubbard dimer as a source of continuous-variable Einstein-Podolsky-Rosen (EPR) steering with non-Gaussian statistics. We use the truncated Wigner representation to calculate third and fourth order cumulants, finding clear signals of non-Gaussianity. We also calculate the products of inferred quadrature variances which indicate that states demonstrating the EPR paradox are present. Our proposed experimental configuration is extrapolated from current experimental techniques and adds another possibility to the current toolbox of quantum atom optics.
description: 11 pages, 5 figures. arXiv admin note: text overlap with arXiv:1607.01911
N=2 supersymmetric odd-order Pais-Uhlenbeck oscillator
Creators: name: Masterov, Ivan
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We consider an N=2 supersymmetric odd-order Pais-Uhlenbeck oscillator with distinct frequencies of oscillation. The technique previously developed in [Acta Phys. Polon. B 36 (2005) 2115; Nucl. Phys. B 902 (2016) 95] is used to construct a family of Hamiltonian structures for this system.
description: v1: 17 pages; v2: 18 pages; typos corrected, clarifying remarks included into Section 3 and Conclusion; Section 5, references, and acknowledgements added; published version
Contributions to the study of exit flow angle in radial turbomachines
Creators: name: Brizuela, Edward A.
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Designing potent inhibitors against the multidrug resistance P-glycoprotein
Creators: name: Mahmud, Shafi
name: Islam, Md. Jahirul
name: Parves, Md. Rimon
name: Khan, Md. Arif
name: Tabussum, Lamiya
name: Ahmed, Sinthyia
name: Ali, Md. Ackas
name: Fakayode, Sayo O.
name: Halim, Mohammad A.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: The multidrug transporter P-glycoprotein is an ATP binding cassette (ABC) exporter responsible for resistance to tumor cells during chemotherapy. This study was designed with computational approaches aimed at identifying the best potent inhibitors of P-glycoprotein. Although many compounds have been suggested to inhibit P-glycoprotein, however, their information on bioavailability, selectivity, ADMET properties, and molecular interactions has not been revealed. Molecular docking, ADMET analysis, molecular dynamics, Principal component analysis (PCA), and binding free energy calculations were performed. Two compounds D1 and D2 showed the best docking score against P-glycoprotein and both compounds have 4-thiazolidinone derivatives containing indolin-3 one moiety are novel anti-tumor compounds. ADMET calculation analysis predicted D1 and D2 to have acceptable pharmacokinetic properties. The MD simulation discloses that D1-P-glycoprotein and D2-P-glycoprotein complexes are in stable conformation as apo-form. Hydrophobic amino acid such as phenylalanine plays significant on the interactions of inhibitors. Principal component analysis shows that both complexes are relatively similar variables as apo-form except planarity and Columbo energy profile. In addition, Quantitative Structural Activity Relationship (QSAR) of the ligand candidates were subjected to the principal component analysis (PCA) for pattern recognition. Partial-least-square (PLS) regression analysis was further utilized to model drug candidates’ QSAR for subsequent prediction of the binding energy of validated drug candidates. PCA revealed groupings of the drug candidates based on the similarity or differences in drug candidates QSAR. Moreover, the developed PLS regression accurately predicted the values of the binding energy of drug candidates, with low residual error of prediction. Communicated by Ramaswamy H. Sarma
Quantum biochemistry, molecular docking, and dynamics simulation revealed synthetic peptides induced conformational changes affecting the topology of the catalytic site of SARS-CoV-2 main protease
Creators: name: Amaral, Jackson L.
name: Oliveira, Jose T. A.
name: Lopes, Francisco E. S.
name: Freitas, Cleverson D. T.
name: Freire, Valder N.
name: Abreu, Leonardo V.
name: Souza, Pedro F. N.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: The recent outbreak caused by SARS-CoV-2 continues to threat and take many lives all over the world. The lack of an efficient pharmacological treatments are serious problems to be faced by scientists and medical staffs worldwide. In this work, an in silico approach based on the combination of molecular docking, dynamics simulations, and quantum biochemistry revealed that the synthetic peptides RcAlb-PepI, PepGAT, and PepKAA, strongly interact with the main protease (Mpro) a pivotal protein for SARS-CoV-2 replication. Although not binding to the proteolytic site of SARS-CoV-2 Mpro, RcAlb-PepI, PepGAT, and PepKAA interact with other protein domain and allosterically altered the protease topology. Indeed, such peptide-SARS-CoV-2 Mpro complexes provoked dramatic alterations in the three-dimensional structure of Mpro leading to area and volume shrinkage of the proteolytic site, which could affect the protease activity and thus the virus replication. Based on these findings, it is suggested that RcAlb-PepI, PepGAT, and PepKAA could interfere with SARS-CoV-2 Mpro role in vivo. Also, unlike other antiviral drugs, these peptides have no toxicity to human cells. This pioneering in silico investigation opens up opportunity for further in vivo research on these peptides, towards discovering new drugs and entirely new perspectives to treat COVID-19. Communicated by Ramaswamy H. Sarma
Effect of Trade Openness on Inflation in Ethiopia (An Auto Regressive Distributive Lag Approach)
Creators: name: Feleke, Meseret
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2014

description: This study empirically examine the effect of trade openness on inflation in Ethiopia using annual time series data over the period 1970/1971-2010/2011 by applying auto regressive distributed lag(ARDL) model for inflation. The control variables that are included in the inflation equation are gross fixed capital formation, money supply, per capita income and government consumption expenditure. The objective of this study is to test the applicability of Romer hypothesis in Ethiopia. In the contrary to Romer hypothesis the finding of the study indicates that the role of trade openness on reducing inflation is insignificant both in the long run and short run. The result of the study confirms that among the control variables included in the inflation equation, gross fixed capital formation significantly reduce inflation. But money supply, per capita income and government consumption expenditure have a positive and significant effect both in the long run and short run. The most important policy implication that comes out of this study is that the policy makers should focus on measures other than external trade sector such as money supply and government expenditure in devising policies to combat and reduce domestic inflation.
Drying in superheated steam-fluidized beds
Creators: name: Bee, Colin
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Special divisors on curves on K3 surfaces carrying an Enriques involution
Creators: name: Ramponi, Marco
Publisher: name: arXiv
Year: 2016
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics

description: We study the pencils of minimal degree on the smooth curves lying on a K3 surface X which carries a fixed-point free involution. Generically, the gonality of these curves is totally governed by the genus 1 fibrations of X
description: 8 pages; simplified and shortened exposition; to appear in Manuscr. Math