cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
SARS-CoV-2: The Monster Causes COVID-19
Creators: name: Song, Chang
name: Li, Zesong
name: Li, Chen
name: Huang, Meiying
name: Liu, Jianhong
name: Fang, Qiuping
name: Cao, Zitong
name: Zhang, Lin
name: Gao, Pengbo
name: Nie, Wendi
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: COVID-19
subject: pandemic
subject: prevention
subject: SARS-CoV-2
subject: therapy
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Coronaviruses are viruses whose particles look like crowns. SARS-CoV-2 is the seventh member of the human coronavirus family to cause COVID-19 which is regarded as a once-in-a-century pandemic worldwide. It holds has the characteristics of a pandemic, which has broy -55ught many serious negative impacts to human beings. It may take time for humans to fight the pandemic. In addition to humans, SARS-CoV-2 also infects animals such as cats. This review introduces the origins, structures, pathogenic mechanisms, characteristics of transmission, detection and diagnosis, evolution and variation of SARS-CoV-2. We summarized the clinical characteristics, the strategies for treatment and prevention of COVID-19, and analyzed the problems and challenges we face.
Additional file 2 of Changes in serum TG levels during pregnancy and their association with postpartum hypertriglyceridemia: a population-based prospective cohort study
Creators: name: Zhu, Yandi
name: Zhu, Haiyan
name: Dang, Qinyu
name: Yang, Qian
name: Huang, Dongxu
name: Zhang, Yadi
name: Cai, Xiaxia
name: Yu, Huanling
Publisher: name: figshare
Year: 2021
Subjects: Cell Biology
Mathematical Sciences not elsewhere classified
Developmental Biology
Cancer

description: Title of data: Certificate of language editing from American Journal Experts.
GDPR Compliance and Data Management Planning – An Integrated Approach
Creators: name: Segadal, Katrine
name: Myhren, Marianne
name: Kvamme, Trond
name: Jondahl, Ida
Publisher: name: Zenodo
Year: 2019
Subjects: data management plans
privacy
GDPR
data protection

description: This presentation will focus on our new cooperation between the data curation unit and the data protection unit.

 Researchers are experiencing increased demands from authorities and financers both in terms of open science and data protection (e.g. GDPR). Horizon 2020 has launched a pilot to maximize access to research data and participating projects have to develop a Data Management Plan (DMP).

 Privacy and open science may be understood as conflicting considerations. However, data protection is a prerequisite for collecting, analyzing, archiving and sharing data. In order to share data while maintaining the privacy of the research participants, expertise in both areas is required.

 NSD is a centre for research data with expertise on data protection. We are in the process of implementing new systems both technically and organizationally which will help researchers accommodate demands with the smallest effort necessary: They can fill out a DMP and document their processing of personal data through the same interface. The aim of this integrated approach is to consider whether research data falls within the remit of GDPR, and guide the researcher in taking the necessary steps to meet its requirements and enable FAIR data sharing.
title: ADCO, Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.1 (début XIIIe siècle), Cart. 166 (11 H 64), 136 folios, f. 0001v
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.1 (début XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 166 (11 H 64), 136 folios, f. 0001v, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.1 (début XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 166 (11 H 64), 136 folios, f. 0001v, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Memories of George Wady
Creators: name: Project Team, Their Finest Hour
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: We would like to share the story of our father, George Wady. He was a commoner, but he was wonderful. He was born in Islington in 1925. He signed up early. His mum passed away when he was doing Basic Training. He volunteered - he wasn't called up. This is why he came home within 30 days. But his mother died. He arrived in France on the 10th Day of D-Day- D-Day10 on the 16th.He spent his 19th birthday in Normandy 12 days after D-Day. He landed on Gold Beach. He was a Member of the Kings Royal Rifles (Green Jackets). They were originally territorial battalions. He was a soldier in an Infantry Battalion support 3 tank regiments.He kept a lot to himself.
He was a wonderful character - he was exceptional - he had a wonderful sense of humour. He was just joyful. We think of him with great affection.During his time in the army, he went through Europe to Germany. He served until 1947 (when Tony was 9 months old). We have an extract from a book - he was in B company. His company commander Bill Deeds (editor of the Telegraph) wrote some books about the Kings Royal Rifles. All were very young (the boys battalion). He was wounded thrice. (They recently went to a D-Day 60th Anniversary and the mayor remembered George Wady!).There are many in the military in our family. There are many mementoes - photos and images.A French historian wrote to George Wady about the London Regiment (GW was injured at the Battle of Bray-et-lu). The French historian wanted to pinpoint details about the French villagers being used as a shield. Peter Plumtree mentioned that they thought George Wady had died and he had not. At Memorial Day - 50 years later, they saw each other alive. He was wounded again 3 weeks before the war ended at the Twente Canal (in Holland). Half a company were lost. It has a canal lock they were ordered to take the canal. 90 were wounded and 16 were killed. George Wady was wounded. The war ended in 1945 and, at the end, he was stationed at the railway station at Bryn. Then he went to Hanover. They were disbanded. They had thought they were going to be sent to Burma. He was still in Germany until 1947, like a gaoler for FSS. Grandad spoke a fair amount of Yiddish because he grew up in Islington and it was like a ghetto. He would have been involved in firing squads. They blew trumpets to say it was the end of the war!He didn't talk about the war for a long time. But they used to go to the Cheshire Cheese old pub in London on Fleet Street and drink with Bill Deeds. We are very proud of him. He could light up the room. We just adore him.
Madrid, Biblioteca Nacional de España, R/12531, fol. 29v-33v, traduction française (Gregorius Digital E1-1)
Creators: name: Andersen, Peter
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2025

description: Ce document Word est une traduction française de l'exemplaire Madrid, Biblioteca Nacional de España, R/12531, fol. 29v-33v, de l’édition espagnole « El Patrañuelo », Valence, Juan Mey, 1567, contient le récit du Bon Pécheur et est édité dans le cadre du projet Gregorius Digital sous le sigle E1-1 (dir. Peter Andersen – ARCHE UMR 3400 – Université de Strasbourg)
Antifungal activity of Annona coriacea Mart. ethanol extracts against the aetiological agents of cryptococcosis
Creators: name: Almeida-Apolonio, Adriana Araújo De
name: Dantas, Fabiana Gomes Da Silva
name: Rodrigues, Allan Belarmino
name: Cardoso, Claudia Andréa Lima
name: Melyssa Negri
name: Oliveira, Kelly Mari Pires De
name: Chang, Marilene Rodrigues
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology
subject: 60506 Virology

description: Cryptococcosis is an opportunistic disease with a worldwide distribution. This disease is caused by fungi of the genus Cryptococcus, and its treatment is limited to several antifungals. In this study, the antifungal, cytotoxic and mutagenic properties of ethanol extracts from the bark and leaves of Annona coriacea were evaluated against the standard Cryptococcus species and clinical yeast specimens. Both extracts of A. coriacea showed inhibitory activity of 1.5 mg/mL for all of the yeasts tested. The number of viable cells at the lowest tested concentration was 0.187 mg/mL. The extracts that were tested showed inhibitory activity and reduced the fungal growth of the Cryptococcus gattii species and Cryptococcus neoformans species complexes, suggesting that this plant may be an effective alternative treatment for cryptococcosis.
Risk and Prognostic Factors for BRAFV600E Mutations in Papillary Thyroid Carcinoma
Creators: name: Wei, Xiaojing
name: Wang, Xiaodong
name: Xiong, Jie
name: Li, Chen
name: Liao, Yixuan
name: Zhu, Yongjun
name: Mao, Jingxin
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: papillary thyroid carcinoma
subject: mutant gene
subject: risk factors
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::614 Inzidenz und Prävention von Krankheiten

description: Background. Over the past ten years, the incidence rate of papillary thyroid carcinoma (PTC) worldwide has been increasing rapidly year by year, with the incidence rate increasing 6% annually. PTC has become the malignant tumor with the highest growth rate in the world that fourteen PTC-related mutant genes have been identified. Whether the BRAFV600E mutation related to more aggressive clinicopathologic features and worse outcome in PTC remains variable and controversial. We aim to investigate the risk factors that may predict the BRAFV600E mutation potential of these lesions and new prevention strategies in PTC patients. Methods. A total of 9,908 papillary thyroid carcinoma patients with average 74.6% BRAFV600E mutations were analyzed (RevMan 5.3 software) in this study. The PubMed, Embase, and ISI Web of Science databases were systematically searched for works published through December 15, 2021. Results. The following variables were associated with an increased risk of BRAFV600E mutation in PTC patients: age >= 45 years (OR = 1.39, 95%CI = 1.21 - 1.60, p < 0.00001), male gender (OR = 1.13, 95%CI = 0.99 - 1.28, p = 0.06), multifocality (OR = 1.22, 95%CI = 1.07 - 1.40, p = 0.004), lymph node metastasis (OR = 1.33, 95%CI = 0.79 - 2.23, p = 0.28), extrathyroidal extension + (OR = 1.61, 95%CI = 1.06 - 2.44, p = 0.03), vascular invasion + (OR = 2.04, 95%CI = 1.32 - 3.15, p = 0.001), and tumor node metastasis stage (OR = 1.61, 95%CI = 1.38 - 1.88, p < 0.00001). In addition, tumor size (> 1 cm) (OR = 0.51, 95%CI = 0.32 - 0.81, p = 0.005) and distant metastasis (OR = 0.69, 95% CI = 0.22 - 2.21, p = 0.54) had no association or risk with BRAF(V600E )mutation in PTC patients. Conclusion. Our systematic review identified the following significant risk factors of BRAF(V600E) mutation in PTC patients: age (>= 45 years), gender (male), multifocality, lymph node metastasis, vascular invasion, extrathyroidal extension, and advanced tumor node metastasis stage (stages III and IV). Tumor size (> 1 cm) and distant metastasis do not appear to be correlated with BRAFV600E mutation in PTC patients.
Cosmological dynamics of magnetic Bianchi I in viable $f(R)$ models of gravity
Creators: name: Liu, Xuyang
name: Channuie, Phongpichit
name: Samart, Daris
Publisher: name: arXiv
Year: 2017
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Standard dynamical system analysis of Einstein-Maxwell equation in $f(R)$ theories is considered in this work. We investigate cosmological dynamics of a uniform magnetic field in the Orthogonal Spatially Homogeneous (OSH) Bianchi type I universe with viable $f(R)$ models of gravity. In this work, the $f(R) = R -αR^n$ and $f(R) = \left( R^b - Λ\right)^c$ models are examined by using our dynamical system analysis. Our results show that both of two $f(R)$ models have a viable cosmological consequence identical to the analysis present in Ref.\cite{Amendola:2007nt} for the FLRW background. Contrary to Ref.\cite{Amendola:2007nt}, we discover in our models that there is an additional anisotropic and non-zero cosmological magnetic fields fixed point emerging before the present of the standard matter epoch. This means that the universe has initially isotropic stage with the intermediated epoch as the anisotropic background and it ends up with the isotropic late-time acceleration. The primordial magnetic fields play a crucial role of the shear evolutions obtained from these two models which have the same scaling of the cosmic time as $σ\sim t^{-\frac13}$, instead of $σ\sim t^{-1}$ for the absence of the primordial magnetic cases.
description: 18 pages, 2 figures. Accepted for publication in physics of the dark universe. Manuscript incorporates responses to referee comments and adds references
Time-bin to Polarization Conversion of Ultrafast Photonic Qubits
Creators: name: Kupchak, Connor
name: Bustard, Philip J.
name: Heshami, Khabat
name: Erskine, Jennifer
name: Spanner, Michael
name: England, Duncan G.
name: Sussman, Benjamin J.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The encoding of quantum information in photonic time-bin qubits is apt for long distance quantum communication schemes. In practice, due to technical constraints such as detector response time, or the speed with which co-polarized time-bins can be switched, other encodings, e.g. polarization, are often preferred for operations like state detection. Here, we present the conversion of qubits between polarization and time-bin encodings using a method that is based on an ultrafast optical Kerr shutter and attain efficiencies of 97% and an average fidelity of 0.827+/-0.003 with shutter speeds near 1 ps. Our demonstration delineates an essential requirement for the development of hybrid and high-rate optical quantum networks.
War Memories - Peggy and George Wood
Creators: name: Project Team, Their Finest Hour
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: My Nana and Grandad, Peggy and George Wood, were involved in the war. My Uncle went into the RAF because my Grandad was in the RAF.My Grandad was a Flying Officer in 525 Squadron on a Dakota C47 flight 562, on a flight from Lyneham to Karachi and back. The journey lasted 10 days and started on 13th October 1944. (Photos of flight schedule)On arriving over the Brittany coastline, flak was sighted from St Nazaire. Unfortunately, the plane was very low on fuel and would not make it to the British coastline. A decision was made to land on farmland in St Nazaire, near Nantes. The 'Maquis' saw the plane descending to their land, ran out with camouflage tarpaulin, hurriedly covered the plane, and towed it under trees. The Nazis were in the next village. After such a long journey, the crew and passengers were very grateful to be welcomed for a cooked chicken dinner and overnight accommodation. The USAAF were in the village on the opposite side to the Germans. They managed to get aviation fuel to the Dakota, enabling it to continue on its journey to Nantes, then on to Rennes. From Rennes, they flew to Lyneham, arriving on 23rd October 1944 at 09:10. The total time of this journey was 53 hours.This was the only 'story' Dad told us, as since reading the whole logbook of his experiences during WWII, he always kept them 'in the past'.Dad finished his time with the RAFVR as Flt/Lt.
Long Non-Coding RNA-TMPO-AS1 as ceRNA Binding to let-7c-5p Upregulates STRIP2 Expression and Predicts Poor Prognosis in Lung Adenocarcinoma
Creators: name: Wang, Juan
name: Yuan, Yixiao
name: Tang, Lin
name: Zhai, Haoqing
name: Zhang, Dahang
name: Duan, Lincan
name: Jiang, Xiulin
name: Li, Chen
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: striatin-interacting protein 2
subject: prognosis biomarkers
subject: tumor immune infiltration
subject: lung adenocarcinoma
subject: cell proliferation
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Striatin-interacting protein 2 (STRIP2), also called Fam40b, has been reported to regulate tumor cell growth. But the role of STRIP2 in lung adenocarcinoma (LUAD) has not been discovered clearly. Thus, the aim of our study is to explore the function and underlying mechanism of STRIP2 in LUAD. Methods: Expression of STRIP2 was determined using the Cancer Genome Atlas (TCGA), GTEx, Ualcan, and the Human Protein Altas databases. The Correlation of STRIP2 and survival was detected by PrognoScan and Kaplan–Meier plotter databases. Besides, the correlation between STRIP2 expression and tumor immune infiltration as well as immune checkpoints were analyzed by the ssGSEA method. The biological function of STRIP2 and its co-expression genes was determined by gene ontology (GO) and Genes and Genomes (KEGG), respectively. Finally, the expression level and biological function of STRIP2 in LUAD were determined by qPCR, CCK8, transwell, and wound healing assays. Results: This manuscript revealed a significantly increased expression of mRNA and protein of STRIP2 in lung adenocarcinoma compared with the adjacent normal tissues. GEO and Kaplan–Meier plotter databases showed higher STRIP2 expression levels were correlated with poor prognosis survival of LUAD. Moreover, Cox regression analysis suggested that a higher STRIP2 level served as an independent risk factor in predicting deteriorative overall survival (OS) for LUAD patients. SsGSEA results showed STRIP2 expression level was positively correlated with infiltrating levels of Th2 cells in LUAD. Lastly, GO analysis indicated the biological processes were enriched in nuclear division and positive regulation of the cell cycle. KEGG signaling pathway analysis showed STRIP2 was correlated with the MAPK signaling pathway and the TNF signaling pathway. The GSEA database showed that STRIP2 was positively associated with the epithelial–mesenchymal transition, cell cycle, and TNF signaling pathway. The QRT-PCR assay showed that STRIP2 was upregulated in LUAD cell lines. Cell proliferation and migration were inhibited in LUAD by knockdown of STRIP2. Moreover, we confirmed that the TMPO-AS1/let-7c-5p/STRIP2 network regulates STRIP2 overexpression in LUAD and is associated with poor prognosis. Conclusion: Our findings indicated that STRIP2 acted as a crucial oncogene in LUAD and was correlated with unfavorable survival and tumor infiltration inflation.
Insensitivity of active nematic dynamics to topological constraints
Creators: name: Norton, Michael M.
name: Baskaran, Arvind
name: Opathalage, Achini
name: Langeslay, Blake
name: Fraden, Seth
name: Baskaran, Aparna
name: Hagan, Michael
Publisher: name: arXiv
Year: 2017
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Confining a liquid crystal imposes topological constraints on the orientational order, allowing global control of equilibrium systems by manipulation of anchoring boundary conditions. In this article, we investigate whether a similar strategy allows control of active liquid crystals. We study a hydrodynamic model of an extensile active nematic confined in containers, with different anchoring conditions that impose different net topological charges on the nematic director. We show that the dynamics are controlled by a complex interplay between topological defects in the director and their induced vortical flows. We find three distinct states by varying confinement and the strength of the active stress: a topologically minimal state, a circulating defect state, and a turbulent state. In contrast to equilibrium systems, we find that anchoring conditions are screened by the active flow, preserving system behavior across different topological constraints. This observation identifies a fundamental difference between active and equilibrium materials.
Identification of LINC00654-NINL Regulatory Axis in Diffuse Large B-Cell Lymphoma In Silico Analysis
Creators: name: Chen, Yinchu
name: Li, Chen
name: Wang, Nana
name: Wu, Zhenghao
name: Zhang, Jin
name: Yan, Jiawei
name: Wei, Yuanfeng
name: Peng, Qunlong
name: Qi, Jing
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: DLBCL
subject: NINL
subject: random forest
subject: LINC00654
subject: mechanism
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: The long non-coding RNA (lncRNA)-mRNA regulation network plays an important role in the development of diffuse large B-cell lymphoma (DLBCL). This study uses bioinformatics to find an innovative regulation axis in DLBCL that will provide a positive reference for defining the mechanism of disease progression. Methods: Batch Cox regression was used to screen prognosis-related lncRNAs, and a random forest model was used to identify hub lncRNA. The clinical value of the lncRNA was evaluated and Spearman correlation analysis was used to predict the candidate target genes. Gene Oncology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment were used to define the biological function of the lncRNA. A batch Cox regression model, expression validation, and Spearman correlation analysis were used to select the best downstream target genes. The expression and prognostic value validation of this gene was conducted using public data. Gene Set Enrichment Analysis (GSEA) was performed to explore potential mechanisms for this gene in DLBCL. Results: LINC00654 was identified as the hub lncRNA and 1443 mRNAs were selected as downstream target genes of the lncRNA. The target genes were enriched in the regulation of GTPase and Notch signaling pathways. After validation, the ninein-like (NINL) gene was selected as the potential target of LINC00654 and the LINC00654-NINL axis was constructed. Patients with better responses to therapy were shown to have high NINL gene expression (p-value = 0.036). NINL also had high expression in the DB cell line and low expression in the OCILY3 cell line. Survival analysis showed that high NINL expression was a risk factor for overall survival (OS) and disease-specific survival (DSS) within older patients and those with advanced-stage cancer. GSEA results showed that NINL may be involved in neutrophil-mediated immunity and NF-κB signaling. Conclusion: This study identified a novel LncRNA00654-NINL regulatory axis in DLBCL, which could provide a favorable reference for exploring the possible mechanisms of disease progression.
New Research on the Importance of Cystic Fibrosis Transmembrane Conductance Regulator Function for Optimal Neutrophil Activity
Creators: name: White, Michelle M.
name: Gargoum, Fatma
name: Browne, Niall
name: Hurley, Killian
name: McElvaney, Noel G
name: Reeves, Emer P.
name: Reeves, Emer
Publisher: name: Royal College of Surgeons in Ireland
Year: 2022
Subjects: Medicine

description: Despite tremendous recent advances in our understanding of the molecular and cellular basis of cystic fibrosis (CF), there remains a paradox of why recruited neutrophils fail to eradicate bacterial infections in the airways of individuals with CF. The focus of this chapter is on new research authenticating the CF neutrophil as a key player in disease pathogenesis. Studies specifying intrinsic abnormalities due to a lack of cystic fibrosis transmembrane conductance regulator (CFTR) function, along with reports indicating reprogrammed cell activity secondary to chronic bacterial infection and inflammation, will be discussed.
General relations between the power, efficiency and dissipation for the irreversible heat engines in the nonlinear response regime
Creators: name: Iyyappan, I.
name: Ponmurugan, M.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We derive the general relations between the maximum power, maximum efficiency and minimum dissipation for the irreversible heat engine in nonlinear response regime. In this context, we use the minimally nonlinear irreversible model and obtain the lower and upper bounds of the above relations for the asymmetric dissipation limits. These relations can be simplified further when the system possesses the time-reversal symmetry or anti-symmetry. We find that our results are the generalization of various such relations obtained earlier for different heat engines.
description: Accepted in PRE
Supplementary document for Direct-detected spectroscopy based on plasmonic Schottky photodetector and a deep neural network - 6588237.pdf
Creators: name: Wu, Shaoxiong
name: Chen, Cheng
name: Dai, Yue
name: Ye, Jiayi
name: Xu, Xinyi
name: Liu, Xinyu
name: Tian, Feng
name: Xu, Yang
name: Hu, Huan
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: Uncategorized

description: Supplemental materials
Clinical Eosinophil-Associated Genes can Serve as a Reliable Predictor of Bladder Urothelial Cancer
Creators: name: Xu, Chaojie
name: Song, Lishan
name: Peng, Hui
name: Yang, Yubin
name: Liu, Yi
name: Pei, Dongchen
name: Guo, Jianhua
name: Liu, Nan
name: Liu, Jiabang
name: Li, Xiaoyong
name: Li, Chen
name: Kang, Zhengjun
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: eosinophil
subject: bladder urothelial carcinoma
subject: WGCNA
subject: risk score
subject: immunotherapy
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Background: Numerous studies have shown that infiltrating eosinophils play a key role in the tumor progression of bladder urothelial carcinoma (BLCA). However, the roles of eosinophils and associated hub genes in clinical outcomes and immunotherapy are not well known. Methods: BLCA patient data were extracted from the TCGA database. The tumor immune microenvironment (TIME) was revealed by the CIBERSORT algorithm. Candidate modules and hub genes associated with eosinophils were identified by weighted gene co-expression network analysis (WGCNA). The external GEO database was applied to validate the above results. TIME-related genes with prognostic significance were screened by univariate Cox regression analysis, lasso regression, and multivariate Cox regression analysis. The patient’s risk score (RS) was calculated and divided subjects into high-risk group (HRG) and low-risk group (LRG). The nomogram was developed based on the risk signature. Models were validated via receiver operating characteristic (ROC) curves and calibration curves. Differences between HRG and LRG in clinical features and tumor mutational burden (TMB) were compared. The Immune Phenomenon Score (IPS) was calculated to estimate the immunotherapeutic significance of RS. Half-maximal inhibitory concentrations (IC50s) of chemotherapeutic drugs were predicted by the pRRophetic algorithm. Results: 313 eosinophil-related genes were identified by WGCNA. Subsequently, a risk signature containing 9 eosinophil-related genes (AGXT, B3GALT2, CCDC62, CLEC1B, CLEC2D, CYP19A1, DNM3, SLC5A9, SLC26A8) was finally developed via multiplex analysis and screening. Age (p < 0.001), grade (p < 0.001), and RS (p < 0.001) were independent predictors of survival in BLCA patients. Based on the calibration curve, our risk signature nomogram was confirmed as a good predictor of BLCA patients’ prognosis at 1, 3, and 5 years. The association analysis of RS and immunotherapy indicated that low-risk patients were more credible for novel immune checkpoint inhibitors (ICI) immunotherapy. The chemotherapeutic drug model suggests that RS has an effect on the drug sensitivity of patients. Conclusions: In conclusion, the eosinophil-based RS can be used as a reliable clinical predictor and provide insights into the precise treatment of BLCA.
MOESM1 of Two inhibitors of yeast plasma membrane ATPase 1 (ScPma1p): toward the development of novel antifungal therapies
Creators: name: Ottilie, Sabine
name: Goldgof, Gregory
name: Cheung, Andrea
name: Walker, Jennifer
name: Vigil, Edgar
name: Allen, Kenneth
name: Antonova-Koch, Yevgeniya
name: Slayman, Carolyn
name: Suzuki, Yo
name: Durrant, Jacob
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Table S1. A list of additional antifungal compounds found in our whole-cell screen. Figure S1. IC50 curves for the cell-free, vesicle-based ScPma1p assays. Figure S2. IC50 curves for the whole-cell assays. Figure S3. Compound IC50 values against whole-cell ABC16-Monster yeast, with and without two distinct spiroindolone-binding-pocket ScPMA1 mutations (L290S and P399T).
Construction of a miRNA-Based Nomogram Model to Predict the Prognosis of Endometrial Cancer
Creators: name: Ni, Leyi
name: Tang, Chengyun
name: Wang, Yuning
name: Wan, Jiaming
name: Charles, Morgan G.
name: Zhang, Zilong
name: Li, Chen
name: Zeng, Ruijie
name: Jin, Yiyao
name: Song, Penghao
name: Wei, Ming
name: Li, Bocen
name: Zhang, Jin
name: Wu, Zhenghao
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: endometrial cancer
subject: differentially expressedmicroRNA
subject: TCGA
subject: nomogram
subject: survival analysis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik

description: Objective: To investigate the differential expression of microRNA (miRNA) in patients with endometrial cancer and its relationship with prognosis and survival. Method: We used The Cancer Genome Atlas (TCGA) database to analyze differentially expressed miRNAs in endometrial cancer tissues and adjacent normal tissues. In addition, we successfully screened out key microRNAs to build nomogram models for predicting prognosis and we performed survival analysis on the key miRNAs as well. Result: We identified 187 differentially expressed miRNAs, which includes 134 up-regulated miRNAs and 53 down-regulated miRNAs. Further univariate Cox regression analysis screened out 47 significantly differentially expressed miRNAs and selected 12 miRNAs from which the prognostic nomogram model for ECA patients by LASSO analysis was constructed. Survival analysis showed that high expression of hsa-mir-138-2, hsa-mir-548f-1, hsa-mir-934, hsa-mir-940, and hsa-mir-4758 as well as low-expression of hsa-mir-146a, hsa-mir-3170, hsa-mir-3614, hsa-mir-3616, and hsa-mir-4687 are associated with poor prognosis in EC patients. However, significant correlations between the expressions levels of has-mir-876 and hsa-mir-1269a and patients’ prognosis are not found. Conclusion: Our study found that 12 significantly differentially expressed miRNAs might promote the proliferation, invasion, and metastasis of cancer cells by regulating the expression of upstream target genes, thereby affecting the prognosis of patients with endometrial cancer.
Directional Design of Materials Based on the Multi-Objective Optimization: A Case Study of Two-Dimensional Thermoelectric SnSe
Creators: name: Yan, Shenshen
name: Wang, Yi
name: Gao, Zhibin
name: Long, Yang
name: Ren, Jie
Publisher: name: arXiv
Year: 2017
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: Directional design of functional materials with multi-objective constraints is a big challenge, whose performance and stability are determined by different physics factors entangled with each other complicatedly. In this work, we apply the multi-objective optimization based on the Pareto Efficiency and Particle-Swarm Optimization methods to design new functional materials directionally. As a demonstration, we achieve the thermoelectric design of 2D SnSe materials through the methods. We identify several novel metastable 2D SnSe structures with simultaneously lower free energy and better thermoelectric performance over the experimentally-reported monolayer structures. We hope our results about the multi-objective Pareto Optimization method can make a step towards the integrative design of multi-objective and multi-functional materials in the future.
description: 11 pages, 8 figures, 4 tables, published as Chin.Phys.Lett. Vol.38, No.2 (2021) 027301, and can be found in http://cpl.iphy.ac.cn/10.1088/0256-307X/38/2/027301
Bulk-to-boundary anyon fusion from microscopic models
Creators: name: Magdalena De La Fuente, Julio C.
name: Eisert, Jens
name: Bauer, Andreas
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: Topological phases
subject: Spacetime physics
subject: Group theoretical methods
subject: 500 Naturwissenschaften und Mathematik::530 Physik::530 Physik

description: Topological quantum error correction based on the manipulation of the anyonic defects constitutes one of the most promising frameworks towards realizing fault-tolerant quantum devices. Hence, it is crucial to understand how these defects interact with external defects such as boundaries or domain walls. Motivated by this line of thought, in this work, we study the fusion events between anyons in the bulk and at the boundary in fixed-point models of 2 + 1-dimensional non-chiral topological order defined by arbitrary fusion categories. Our construction uses generalized tube algebra techniques to construct a bi-representation of bulk and boundary defects. We explicitly derive a formula to calculate the fusion multiplicities of a bulk-to-boundary fusion event for twisted quantum double models and calculate some exemplary fusion events for Abelian models and the (twisted) quantum double model of S3, the simplest non-Abelian group-theoretical model. Moreover, we use the folding trick to study the anyonic behavior at non-trivial domain walls between twisted S3 and twisted as well as models. A recurring theme in our construction is an isomorphism relating twisted cohomology groups to untwisted ones. The results of this work can directly be applied to study logical operators in two-dimensional topological error correcting codes with boundaries described by a twisted gauge theory of a finite group.
Additional file 8: of X chromosome dosage and presence of SRY shape sex-specific differences in DNA methylation at an autosomal region in human cells
Creators: name: Ho, Bianca
name: Greenlaw, Keelin
name: Tuwaijri, Abeer Al
name: Moussette, Sanny
name: Martínez, Francisco
name: Giorgio, Elisa
name: Brusco, Alfredo
name: Ferrero, Giovanni
name: Linhares, Natália
name: Eugênia Valadares
name: Svartman, Marta
name: Kalscheuer, Vera
name: Criado, Germán Rodríguez
name: Laprise, Catherine
name: Greenwood, Celia
name: Naumova, Anna
Publisher: name: figshare
Year: 2018
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Hematology

description: Table S5. Univariate analysis results, full model multivariate analysis results, as well as post hoc power calculations. (DOCX 14 kb)
Memories of Able Seaman James Robert Gray RN
Creators: name: Project Team, Their Finest Hour
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Onboard the HMS Onslow - Destroyer.Private Harry Noon - 8th Army - North Africa.Able Seaman Gray travelled from Gibraltar to Russia through the Atlantic to escort the Merchant Navy Ships carrying supplies for the war effort. He was torpedoed twice, having to dock in Belfast fore repairs and then served on several other ships whilst his ship the Onslow was repaired. The average forays undertaken by the ships crew was 2-3 journeys, however AB Gray went on 6.
New Research on the Importance of Cystic Fibrosis Transmembrane Conductance Regulator Function for Optimal Neutrophil Activity
Creators: name: White, Michelle M.
name: Gargoum, Fatma
name: Browne, Niall
name: Hurley, Killian
name: McElvaney, Noel G.
name: Reeves, Emer P.
Publisher: name: Royal College of Surgeons in Ireland
Year: 2019
Subjects: Medicine

description: Despite tremendous recent advances in our understanding of the molecular and cellular basis of cystic fibrosis (CF), there remains a paradox of why recruited neutrophils fail to eradicate bacterial infections in the airways of individuals with CF. The focus of this chapter is on new research authenticating the CF neutrophil as a key player in disease pathogenesis. Studies specifying intrinsic abnormalities due to a lack of cystic fibrosis transmembrane conductance regulator (CFTR) function, along with reports indicating reprogrammed cell activity secondary to chronic bacterial infection and inflammation, will be discussed.
Quantum interference of position and momentum: a particle propagation paradox
Creators: name: Hofmann, Holger F.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Optimal simultaneous control of position and momentum can be achieved by maximizing the probabilities of finding their experimentally observed values within two well-defined intervals. The assumption that particles move along straight lines in free space can then be tested by deriving a lower limit for the probability of finding the particle in a corresponding spatial interval at any intermediate time t. Here, it is shown that this lower limit can be violated by quantum superpositions of states confined within the respective position and momentum intervals. These violations of the particle propagation inequality show that quantum mechanics changes the laws of motion at a fundamental level, providing a new perspective on causality relations and time evolution in quantum mechanics.
description: 6 pages, including one figure, added discussions of experimental possibilities and the selection of localized states
Supplementary document for Research of CUP-VISAR velocity reconstruction based on weighted DRUNet and total variation joint optimization - 6589831.pdf
Creators: name: Wang, Xi
name: Zhang, Lei
name: Li, Miao
name: Yu, Boshan
name: Guo, Zhaohui
name: Zhao, Xueyin
name: Wang, Feng
name: Li, Yulong
name: Guan, Zanyang
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: Uncategorized

description: 1. CUP-VISAR diagnostic system; 2. Formula derivation details 3. Reconstruction comparative analysis of three algorithms across varied encoded aperture sizes 4. The architecture and training procedures for DRUNet
COL11A1 as an novel biomarker for breast cancer with machine learning and immunohistochemistry validation
Creators: name: Shi, Wenjie
name: Chen, Zhilin
name: Liu, Hui
name: Miao, Chen
name: Feng, Ruifa
name: Wang, Guilin
name: Chen, Guoping
name: Chen, Zhitong
name: Fan, Pingming
name: Pang, Weiyi
name: Li, Chen
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: machine learning
subject: COL11A1
subject: breast cancer
subject: tumor microenvironment
subject: prognosis
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::619 Gynäkologie, Pädiatrie, Geriatrie

description: Machine learning (ML) algorithms were used to identify a novel biological target for breast cancer and explored its relationship with the tumor microenvironment (TME) and patient prognosis. The edgR package identified hub genes associated with overall survival (OS) and prognosis, which were validated using public datasets. Of 149 up-regulated genes identified in tumor tissues, three ML algorithms identified COL11A1 as a hub gene. COL11A1was highly expressed in breast cancer samples and associated with a poor prognosis, and positively correlated with a stromal score (r=0.49, p<0.001) and the ESTIMATE score (r=0.29, p<0.001) in the TME. Furthermore, COL11A1 negatively correlated with B cells, CD4 and CD8 cells, but positively associated with cancer-associated fibroblasts. Forty-three related immune-regulation genes associated with COL11A1 were identified, and a five-gene immune regulation signature was built. Compared with clinical factors, this gene signature was an independent risk factor for prognosis (HR=2.591, 95%CI 1.831–3.668, p=7.7e-08). A nomogram combining the gene signature with clinical variables, showed better predictive performance (C-index=0.776). The model correction prediction curve showed little bias from the ideal curve. COL11A1 is a potential therapeutic target in breast cancer and may be involved in the tumor immune infiltration; its high expression is strongly associated with poor prognosis.
Phase diagrams for quantum Brownian motion models on two-dimensional Bravais lattices
Creators: name: Zhang, Grace H.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We study quantum Brownian motion (QBM) models for a particle in a dissipative environment coupled to a periodic potential. We review QBM for a particle in a one-dimensional periodic potential and extend the study to that for a particle in two-dimensional (2D) periodic potentials of four Bravais lattice types: square, rectangular, triangular (hexagonal), and centered rectangular. We perform perturbative renormalization group analyses to derive the zero temperature flow diagrams and phase boundaries for a particle in these potentials, and observe localization behavior dependent on the anisotropy of the lattice parameters.
description: 16 pages, 5 figures
Activando el aprendizaje activo en el aula: el método Flip Teaching /Aula Invertida
Creators: name: Fidalgo-Blanco, Ángel
Publisher: name: Zenodo
Year: 2020
Subjects: Flip Teaching, Flipped Classroom, Aula Inversa, Aula Invertida, Tendencia Innovación Educativa, Método MAIN

description: Curso impartido en la Universidad del País Vasco. Euskal Herriko Unibertsitatea. 20 y 21 de enero de 2020. Este texto contiene las principales diapositivas utilizadas en las presentaciones teóricas junto con enlaces a videos o explicaciones adicionales con referencias a trabajos de investigación (principalmente del autor). Así mismo se incluyen (al final de cada apartado) una descripción más detallada de los mismos. Es muy habitual que en nuestras aulas el alumnado no coopere ni sea partícipe de su propio aprendizaje. Para solucionar esta situación surgen los métodos activos como Flip Teaching / Aula Invertida. FlipTeaching (FT) es un método para que el alumnado participe de forma activa y cooperativa en el aula. Básicamente consiste en cambiar el lugar donde se imparten las dos principales actividades académicas: la lección y los deberes. Es decir, la lección se toma en casa (por ejemplo, a través de un video), y en clase se hacen los deberes. Competencias a desarrollar: Identificar los procesos más relevantes en el método de Aula Invertida. Identificar indicadores que permitan medir el incremento de participación activa del alumnado. Distinguir los diferentes modelos de Aula Invertida. Diseñar y aplicar una experiencia de innovación educativa basada en el método de Aula Invertida. Diseñar una experiencia de innovación educativa para que sea publicable en contextos científicos.
DataHarvest   building expertise to advance the management of grains research, development and extension data for Australian grain growers
Creators: name: Brown, John
Publisher: name: Zenodo
Year: 2024
Subjects: Training
Repositories
Workforce

description: DataHarvest is a partnership between the Grains Research and Development Corporation (GRDC), the Curtin Centre for Crop Disease and Management and Curtin University Library aimed at advancing the management of grains research, development, and extension (RD&E) data for Australian grain growers. This initiative will enhance the expertise of over 80 GRDC research partners nationwide to help them expertly collect, manage, and share grains RD&E data in a standardised manner, adhering to the FAIR principles Findable, Accessible, Interoperable, and Reusable.

Building on the successes of the GRDC s Data Partnership Initiative, which involved 12 partners developing best practices and locating valuable data, DataHarvest will extend these efforts to a broader range of GRDC s partners. This $2.9 million co-investment, with $1.3 million from GRDC, aims to unlock the full potential of RD&E data, facilitating faster knowledge sharing, and innovation, and avoiding duplication of efforts.

This initiative promises significant advancements in research outcomes, benefiting Australian grain growers through more efficient delivery of new knowledge and RD&E outputs. By embracing FAIR principles and opening avenues for innovative data analytics, DataHarvest sets the stage for a new era in agricultural research data management.

This presentation will outline the initial work, findings and opportunities for the DataHarvest project.