cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Random interlacements and amenability
Creators: name: Teixeira, Augusto
name: Tykesson, Johan
Publisher: name: arXiv
Year: 2011
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: We consider the model of random interlacements on transient graphs, which was first introduced by Sznitman [Ann. of Math. (2) (2010) 171 2039-2087] for the special case of ${\mathbb{Z}}^d$ (with $d\geq3$). In Sznitman [Ann. of Math. (2) (2010) 171 2039-2087], it was shown that on ${\mathbb{Z}}^d$: for any intensity $u>0$, the interlacement set is almost surely connected. The main result of this paper says that for transient, transitive graphs, the above property holds if and only if the graph is amenable. In particular, we show that in nonamenable transitive graphs, for small values of the intensity u the interlacement set has infinitely many infinite clusters. We also provide examples of nonamenable transitive graphs, for which the interlacement set becomes connected for large values of u. Finally, we establish the monotonicity of the transition between the "disconnected" and the "connected" phases, providing the uniqueness of the critical value $u_c$ where this transition occurs.
description: Published in at http://dx.doi.org/10.1214/12-AAP860 the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Simulating quantum statistics with entangled photons: a continuous transition from bosons to fermions
Creators: name: Matthews, Jonathan C. F.
name: Poulios, Konstantinos
name: Meinecke, Jasmin D. A.
name: Politi, Alberto
name: Peruzzo, Alberto
name: Ismail, Nur
name: Wörhoff, Kerstin
name: Thompson, Mark G.
name: O'Brien, Jeremy L.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: In contrast to classical physics, quantum mechanics divides particles into two classes-bosons and fermions-whose exchange statistics dictate the dynamics of systems at a fundamental level. In two dimensions quasi-particles known as 'anyons' exhibit fractional exchange statistics intermediate between these two classes. The ability to simulate and observe behaviour associated to fundamentally different quantum particles is important for simulating complex quantum systems. Here we use the symmetry and quantum correlations of entangled photons subjected to multiple copies of a quantum process to directly simulate quantum interference of fermions, bosons and a continuum of fractional behaviour exhibited by anyons. We observe an average similarity of 93.6\pm0.2% between an ideal model and experimental observation. The approach generalises to an arbitrary number of particles and is independent of the statistics of the particles used, indicating application with other quantum systems and large scale application.
description: 10 pages, 5 figures
Dual lattice representations for O(N) and CP(N-1) models with a chemical potential
Creators: name: Bruckmann, Falk
name: Gattringer, Christof
name: Kloiber, Thomas
name: Sulejmanpasic, Tin
Publisher: name: Universität Regensburg
Year: 2015
Subjects: subject: 530 Physik

description: We derive dual representations for O(N) and CP(N-1) models on the lattice. In terms of the dual variables the partition sums have only real and positive contributions also at finite chemical potential. Thus the complex action problem of the conventional formulation is overcome and using the dual variables Monte Carlo simulations are possible at arbitrary chemical potential.
description: Projekt SCOAP3
Immune escape facilitation by mutations of epitope residues in RdRp of SARS-CoV-2
Creators: name: Gupta, Aayatti Mallick
name: Mandal, SasthiCharan
name: Mandal, Sukhendu
name: Chakrabarti, Jaydeb
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Mutations drive viral evolution and genome variability that causes viruses to escape host immunity and to develop drug resistance. SARS-CoV-2 has considerably higher mutation rate. SARS-CoV-2 possesses a RNA dependent RNA polymerase (RdRp) which helps to replicate its genome. The mutation P323L in RdRp is associated with the loss of a particular epitope (321-327) from this protein. We consider the effects of mutations in some of the epitope region including the naturally occurring mutation P323L on the structure of the epitope and their interface with paratope using all-atom molecular dynamics (MD) simulation studies. We observe that the mutations cause conformational changes in the epitope region by opening up the region associated with increase in the radius of gyration and intramolecular hydrogen bonds, making the region less accessible. Moreover, we study the conformational stability of the epitope region and epitope:paratope interface under the mutation from the fluctuations in the dihedral angles. We observe that the mutation renders the epitope and the epitope:paratope interface unstable compared to the corresponding wild type ones. Thus, the mutations may help in escaping antibody mediated immunity of the host Communicated by Ramaswamy H. Sarma
title: Ermittelte Regeln und Erkenntnisse des Regelermittlungsausschusses nach § 46 des Mess- und Eichgesetzes
title: Stand: 15. November 2021
titleType: Subtitle
Creators: name: Regelermittlungsausschuss bei der Physikalisch-Technischen Bundesanstalt (PTB), Braunschweig
Publisher: name: Physikalisch-Technische Bundesanstalt (PTB)
Year: 2022
Subjects: Regelermittlungsausschuss
REA
Mess- und Eichgesetz
technische Spezifikationen
wesentliche Anforderungen
Verfahren der Konformitätsbewertung
Verwendung von Messgeräten

description: Stand: 15. November 2021
Location Estimation with Reactive Routing in Resource Constrained Sensor Networks
Creators: name: Sarangi, Sanat
name: Kar, Subrat
Publisher: name: arXiv
Year: 2010
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Routing algorithms for wireless sensor networks can be broadly divided into two classes - proactive and reactive. Proactive routing is suitable for a network with a fixed topology. On the other hand, reactive routing is more suitable for a set of mobile nodes where routes are created on demand and there is not much time to evaluate the worthiness of a route, the prime concern being reachability due to constantly changing node positions. Sensor networks route events of interest from source(s) to destination(s) where appropriate actions could be taken. However, with mobile sensor nodes, it is not only important to know the events but the location of the nodes generating the events. Most sensor nodes are not equipped with expensive GPS or accurate RSSI computation hardware to aid localization. Keeping these in view, we propose a modified reactive routing algorithm, with added support for localization, to localize mobile sensor nodes on the basis of information received from fixed sensor nodes during mutual exchange of routing control packets. The accuracy of localization depends on the ratio of the number of fixed nodes to the number of mobile nodes and the topology of the fixed nodes. A typical application scenario would be a mix of mobile nodes and fixed nodes, where fixed nodes know their absolute location and the location of mobile nodes is derived from the fixed nodes, in step with the reactive routing protocol in action. The modified algorithm would be suitable for deployments where the approximate position of a mobile node (i.e. the event location) is required but there is no external support infrastructure available for localization.
description: 6 pages, 6 figures
How Do Participants Deal with Questions If Asked to Rate Visual Dimensions of an Object?
Creators: name: Kattenbeck, Markus
Publisher: name: Universität Regensburg
Year: 2015
Subjects: subject: Pedestrian navigation, Collaborative landmark mining, Visual dimensions, Salience survey
subject: 004 Informatik

description: Research Question: How do participants behave when asked to rate objects’ visual dimensions? Approach: Qualitative Data Analysis Method: 90 participants were asked to rate 11 objects located along a route of 1.1 km length and asked to explain their rating behaviour using a think-aloud protocol. Results: If asked to rate several objects, participants tend to stop reading the questions as a whole. Moreover, when judging objects on visual dimensions they make inconsistent use of local neighbourhoods.
Investigating physical activity communication breast cancer survivors receive from their oncology providers
Creators: name: Fitzpatrick, Kayla Marie
Publisher: name: University of British Columbia
Year: 2017

description: Physical activity (PA) has been shown to combat the negative side effects (e.g., fatigue, pain, depression) often faced by breast cancer (BC) survivors following BC treatment. Several studies have demonstrated that physician promoted PA significantly improves PA participation among BC survivors; however, it is rare that oncology providers recommend or provide advice about PA to survivors. The purpose of this study was to gain a better understanding of the PA communication oncology providers relay to their patients, and to investigate the relationship between this communication and the PA levels of BC survivors. This study was exploratory in nature and used a cross-sectional design. Participants (n=60) were self-identified BC survivors, 18 years or older, and lived in the Okanagan Region of British Columbia, Canada. The adapted, 30-item Oncology Provider Physical Activity Communication (OPPAC) questionnaire was used to assess participants’ perceptions concerning PA communication and advice they receive from their oncology provider. PA was assessed using accelerometers. Data were analysed using descriptive statistics and one-way ANOVA’s were conducted to assess the relationship between PA communication and PA levels. A small proportion of participants (20%) indicated that their oncology provider recommended PA, and only 11.7% indicated that their oncology provider referred them to an exercise professional. Upon further evaluation, data revealed that those who were asked about their PA routines by their oncology provider (35%) had significantly higher PA levels (P=0.038) compared to BC survivors who were not asked. Qualitative results showed that the majority (89%) of survivors thought PA should be a part of treatment. The findings suggest that the PA communication BC survivors receive from their oncology provider is limited; however, a positive relationship does exists between oncology provider communication and minutes of moderate/vigorous physical activity per week. Establishing effective and efficient ways to assist oncology providers with integrating PA promotion into their practice is needed.
Low urinary indoxyl sulfate levels early after transplantation reflect a disrupted microbiome and are associated with poor outcome
Creators: name: Weber, Daniela
name: Oefner, Peter J.
name: Hiergeist, Andreas
name: Koestler, Josef
name: Gessner, Andre
name: Weber, Markus
name: Hahn, Joachim
name: Wolff, Daniel
name: Stämmler, Frank
name: Spang, Rainer
name: Herr, Wolfgang
name: Dettmer, Katja
name: Holler, Ernst
Publisher: name: Universität Regensburg
Year: 2015
Subjects: subject: Urinary 3-IS levels predict outcome after ASCT and are associated with antibiotics and NOD2/CARD15 variants
subject: 004 Informatik
subject: 540 Chemie
subject: 570 Biowissenschaften, Biologie
subject: 610 Medizin

description: Urinary 3-IS levels predict outcome after ASCT and are associated with antibiotics and NOD2/CARD15 variants.Publisher’s Note: There is an Inside Blood Commentary on this article in this issue.Indole, which is produced from l-tryptophan by commensal bacteria expressing tryptophanase, not only is an important intercellular signal in microbial communities, but also modulates mucosal barrier function and expression of pro- and anti-inflammatory genes by intestinal epithelial cells. Here, we hypothesized that decreased urinary excretion of 3-indoxyl sulfate (3-IS), the major conjugate of indole found in humans, may be a marker of gut microbiota disruption and increased risk of developing gastrointestinal (GI) graft-versus-host-disease. Using liquid chromatography/tandem mass spectrometry, 3-IS was determined in urine specimens collected weekly within the first 28 days after allogeneic stem cell transplantation (ASCT) in 131 patients. Low 3-IS levels within the first 10 days after ASCT were associated with significantly higher transplant-related mortality (P = .017) and worse overall survival (P = .05) 1 year after ASCT. Least absolute shrinkage and selection operator regression models trained on log-normalized counts of 763 operational taxonomic units derived from next-generation sequencing of the hypervariable V3 region of the 16S ribosomal RNA gene showed members of the families of Lachnospiraceae and Ruminococcaceae of the class of Clostridia to be associated with high urinary 3-IS levels, whereas members of the class of Bacilli were associated with low 3-IS levels. Risk factors of early suppression of 3-IS levels were the type of GI decontamination (P = .01), early onset of antibiotic treatment (P = .001), and recipient NOD2/CARD15 genotype (P = .04). In conclusion, our findings underscore the relevance of microbiota-derived indole and metabolites thereof in mucosal integrity and protection from inflammation.
Three-dimensional modeling of streptomycin binding single-stranded DNA for aptamer-based biosensors, a molecular dynamics simulation approach
Creators: name: Nosrati, Masoumeh
name: Roushani, Mahmoud
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Computational Biology

description: Streptomycin (STR) an aminoglycoside antibiotic which is used against bacteria in human and animal infection, have serious side effects on different parts of human body. Therefore, there is a crucial need to detect trace amount of it in serum and food products. Aptamers are oligonucleotides or peptides, which bind their targets with high affinity and specificity. These properties make aptamers as suitable candidates for biosensing applications. A 79-mer ss-DNA aptamer was applied for the detection of small amount of STR in various aptasensors. But there is no structural information on the STR-binding aptamer and molecular details underlying the aptamer-STR binding remain unexplored. In this study we provided a 3D-structural model for 79-mer ss-DNA aptamer from the sequence. Using docking program and molecular dynamics (MD) simulation we predicted the binding pocket of ss-DNA aptamer. Our results show STR streptose ring is buried within the groove of DNA model and capped by non Watson-Crick bases. STR interacts with aptamer through forming stable hydrogen bonds. Our computational findings are in fair agreement with experimental results. With the atomic structural details, we gained new insight into the Apt-STR binding interaction that can help to further optimize aptamer efficiency in biosensing applications. Communicated by Ramaswamy H. Sarma
Analysis of Width-$w$ Non-Adjacent Forms to Imaginary Quadratic Bases
Creators: name: Heuberger, Clemens
name: Krenn, Daniel
Publisher: name: arXiv
Year: 2010
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11A63, 11R11, 28A80, 94A60

description: We consider digital expansions to the base of $τ$, where $τ$ is an algebraic integer. For a $w \geq 2$, the set of admissible digits consists of 0 and one representative of every residue class modulo $τ^w$ which is not divisible by $τ$. The resulting redundancy is avoided by imposing the width $w$-NAF condition, i.e., in an expansion every block of $w$ consecutive digits contains at most one non-zero digit. Such constructs can be efficiently used in elliptic curve cryptography in conjunction with Koblitz curves. The present work deals with analysing the number of occurrences of a fixed non-zero digit. In the general setting, we study all $w$-NAFs of given length of the expansion. We give an explicit expression for the expectation and the variance of the occurrence of such a digit in all expansions. Further a central limit theorem is proved. In the case of an imaginary quadratic $τ$ and the digit set of minimal norm representatives, the analysis is much more refined: We give an asymptotic formula for the number of occurrence of a digit in the $w$-NAFs of all elements of $\Z[τ]$ in some region (e.g. a disc). The main term coincides with the full block length analysis, but a periodic fluctuation in the second order term is also exhibited. The proof follows Delange's method. We also show that in the case of imaginary quadratic $τ$ and $w \geq 2$, the digit set of minimal norm representatives leads to $w$-NAFs for \emph{all} elements of $\Z[τ]$. Additionally some properties of the fundamental domain are stated.
Dual lattice representations for O(N) and CP(N-1) models with a chemical potential
Creators: name: Bruckmann, Falk
name: Gattringer, Christof
name: Kloiber, Thomas
name: Sulejmanpasic, Tin
Publisher: name: Universität Regensburg
Year: 2015
Subjects: subject: 530 Physik

description: We derive dual representations for O(N) and CP(N-1) models on the lattice. In terms of the dual variables the partition sums have only real and positive contributions also at finite chemical potential. Thus the complex action problem of the conventional formulation is overcome and using the dual variables Monte Carlo simulations are possible at arbitrary chemical potential.
Colonizzazione ambientale, defuturing capitalocenico e pratiche eco-artistiche decoloniali a sud
Creators: name: D’Autilia, Antonella
name: Cazzato, Luigi Carmine
Publisher: name: Fondazione Università Ca’ Foscari Venezia, Italia
Year: 2020

description:

The present essay aims at offering some interpretative keys for the ecological disaster of one of the most beautiful sites in the Mediterranean: Taranto. It does so through the ecocritical tools of postcolonial and decolonial thinking and the analysis of an intense iconography of eco-artistic urbanist engagements, which have dramatically exemplified what it has meant living in the midst of the largest of Europe’s steelworks. These engagements, having “one foot in literature and the other on land” (Glotfelty, Fromm 1996, XIX), attempt to decolonize the imaginary related to the deeply discordant relationship between the city of Taranto and ‘its’ steelworks, which is more than twice the size of the same city. We have chosen, after Jason Moore (2016), the adjective ‘capitalocenic’ rather than the more voguish ‘anthropocenic’, since the environmental changes are not the end result of an abstract human action, but rather of the tangible century-long rule of capital: the earthless (Vázquez 2017) mode of production of modernity that à la Descartes denies the earth into which it gets its claws and, as a consequence, it denies the deep knitting of “humanity-in-nature/nature-in-humanity” (Moore 2015).

description: Il Tolomeo
Conformal symmetry of the Lange-Neubert evolution equation
Creators: name: Braun, Vladimir M.
name: Manashov, Alexander
Publisher: name: Universität Regensburg
Year: 2014
Subjects: subject: 530 Physik

description: The Lange–Neubert evolution equation describes the scale dependence of the wave function of a meson built of an infinitely heavy quark and light antiquark at light-like separations, which is the hydrogen atom problem of QCD. It has numerous applications to the studies of B -meson decays. We show that the kernel of this equation can be written in a remarkably compact form, as a logarithm of the generator of special conformal transformation in the light-ray direction. This representation allows one to study solutions of this equation in a very simple and mathematically consistent manner. Generalizing this result, we show that all heavy–light evolution kernels that appear in the renormalization of higher-twist B -meson distribution amplitudes can be written in the same form.
Popularity versus Similarity in Growing Networks
Creators: name: Papadopoulos, Fragkiskos
name: Kitsak, Maksim
name: Serrano, M. Angeles
name: Boguna, Marian
name: Krioukov, Dmitri
Publisher: name: arXiv
Year: 2011
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Networking and Internet Architecture (cs.NI)
subject: Social and Information Networks (cs.SI)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Popularity is attractive -- this is the formula underlying preferential attachment, a popular explanation for the emergence of scaling in growing networks. If new connections are made preferentially to more popular nodes, then the resulting distribution of the number of connections that nodes have follows power laws observed in many real networks. Preferential attachment has been directly validated for some real networks, including the Internet. Preferential attachment can also be a consequence of different underlying processes based on node fitness, ranking, optimization, random walks, or duplication. Here we show that popularity is just one dimension of attractiveness. Another dimension is similarity. We develop a framework where new connections, instead of preferring popular nodes, optimize certain trade-offs between popularity and similarity. The framework admits a geometric interpretation, in which popularity preference emerges from local optimization. As opposed to preferential attachment, the optimization framework accurately describes large-scale evolution of technological (Internet), social (web of trust), and biological (E.coli metabolic) networks, predicting the probability of new links in them with a remarkable precision. The developed framework can thus be used for predicting new links in evolving networks, and provides a different perspective on preferential attachment as an emergent phenomenon.
Conformal constraints for anomalous dimensions of leading twist operators
Creators: name: Manashov, Alexander
name: Strohmaier, Matthias
Publisher: name: Universität Regensburg
Year: 2015
Subjects: subject: 530 Physik

description: Leading-twist operators have a remarkable property that their divergence vanishes in a free theory. Recently it was suggested that this property can be used for an alternative technique to calculate anomalous dimensions of leading-twist operators and allows one to gain one order in perturbation theory so that, i.e., two-loop anomalous dimensions can be calculated from one-loop Feynman diagrams, etc. In this work we study the feasibility of this program by a toy-model example of the φ3 theory in six dimensions. Our conclusion is that this approach is valid, although it does not seem to present considerable technical simplifications as compared to the standard technique. It does provide one, however, with a very nontrivial check of the calculation as the structure of the contributions is very different.
description: Projekt SCOAP3
Interpreting Lyman $α$ radiation from young, dusty galaxies
Creators: name: Laursen, Peter
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The significance of the Ly$α$ emission line as a probe of the high-redshift Universe has long been established. Originating mainly in the vicinity of young, massive stars and in association with accretion of large bulks of matter, it is ideal for detecting young galaxies, the fundamental building blocks of our Universe. Since many different processes shape the spectrum and the spatial distribution of the Ly$α$ photons in various ways, a multitude of physical properties of galaxies can be unveiled. However, this also makes the interpretation of Ly$α$ observations notoriously difficult. Because Ly$α$ is a resonant line, it scatters on neutral hydrogen, having its path length from the source to our telescopes vastly increased, and taking it through regions of unknown physical conditions. In this work, a numerical code capable of calculating realistically the radiative transfer of Ly$α$ is presented. The code is capable of performing the radiative transfer in an arbitrary and adaptively refined distribution of Ly$α$ source emission, temperature and velocity field of the interstellar and intergalactic medium, as well as density of neutral and ionized hydrogen, and, particularly important, dust. Accordingly, it is applied to galaxies simulated at high resolution, yielding a number of novel and interesting results, most notably the escape fractions of Ly$α$ photons, the effect of dust on the line profile, and the impact of the transfer through the intergalactic medium. Furthermore, the remarkable detection of Ly$α$ emission from a so-called "damped Ly$α$ absorber" -- a special type of objects thought to be the progenitor of present-day's galaxies -- is presented, and the potential of the code for interpreting observations is demonstrated.
description: Ph.D. thesis, 204 coherently written pages
Conformal constraints for anomalous dimensions of leading twist operators
Creators: name: Manashov, Alexander
name: Strohmaier, Matthias
Publisher: name: Universität Regensburg
Year: 2015
Subjects: subject: 530 Physik

description: Leading-twist operators have a remarkable property that their divergence vanishes in a free theory. Recently it was suggested that this property can be used for an alternative technique to calculate anomalous dimensions of leading-twist operators and allows one to gain one order in perturbation theory so that, i.e., two-loop anomalous dimensions can be calculated from one-loop Feynman diagrams, etc. In this work we study the feasibility of this program by a toy-model example of the φ3 theory in six dimensions. Our conclusion is that this approach is valid, although it does not seem to present considerable technical simplifications as compared to the standard technique. It does provide one, however, with a very nontrivial check of the calculation as the structure of the contributions is very different.
Rosenthal-type inequalities for the maximum of partial sums of stationary processes and examples
Creators: name: Merlevède, Florence
name: Peligrad, Magda
Publisher: name: arXiv
Year: 2011
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: The aim of this paper is to propose new Rosenthal-type inequalities for moments of order higher than 2 of the maximum of partial sums of stationary sequences including martingales and their generalizations. As in the recent results by Peligrad et al. [Proc. Amer. Math. Soc. 135 (2007) 541-550] and Rio [J. Theoret. Probab. 22 (2009) 146-163], the estimates of the moments are expressed in terms of the norms of projections of partial sums. The proofs of the results are essentially based on a new maximal inequality generalizing the Doob maximal inequality for martingales and dyadic induction. Various applications are also provided.
description: Published in at http://dx.doi.org/10.1214/11-AOP694 the Annals of Probability (http://www.imstat.org/aop/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Transverse target single-spin asymmetry in inclusive electroproduction of charged pions and kaons
Creators: name: The Hermes, Collaboration
name: Schäfer, Andreas
Publisher: name: Universität Regensburg
Year: 2014
Subjects: subject: 530 Physik

description: Single-spin asymmetries were investigated in inclusive electroproduction of charged pions and kaons from transversely polarized protons at the HERMES experiment. The asymmetries were studied as a function of the azimuthal angle ψ about the beam direction between the target-spin direction and the hadron production plane, the transverse hadron momentum relative to the direction of the incident beam, and the Feynman variable xF. The sin(ψ) amplitudes are positive for positive pions and kaons, slightly negative for negative pions and consistent with zero for negative kaons, with particular transverse-momentum but weak xF dependences. Especially large asymmetries are observed for two small subsamples of events, where also the scattered electron was recorded by the spectrometer.
description: Projekt SCOAP3
Validation of SQL queries over streaming warehouses
Creators: name: Jain, Ritika
Publisher: name: University of British Columbia
Year: 2017

description: There is often a need to recover the “missing” query that produced a particular output from a data stream. As an example, since a data stream is constantly evolving, the analyst may be curious about using the query from the past to evaluate it on the current state of the data stream, for further analysis. Previous research has studied the problem of reverse engineering a query that would produce a given result at a particular database state. We study the following problem. Given a streaming database D=, a result Rout , and a set of candidate queries Q, efficiently find all queries Qi ϵ Q such that for some state Dji of the stream, Qi(Dji) = Rout , and report the pair (Q,witQ) where witQ is the witness of (in)validity. A witness for a valid query Qval is a state Di s.t. Qval(Di) = Rout. For an invalid query Qinval , a witness is a pair of consecutive states (Di, Di+1) such that Rout \ Qinval (Di) ≠ Ø ≠ Qinval (Di+1) \ Rout. We allow any PTIME computable monotone query to be included in Q. While techniques developed in previous research can be used to generate the candidate query set Q, we focus on developing a scalable strategy for quickly determining the witness. We establish theoretical worst-case performance guarantees for our proposed approach and show that it is no more than a factor of O(log |DRDS|) of the optimal “Lucky guess” strategy, where Q(DRDS) = Rout. We empirically evaluate our technique and compare with natural baselines inspired from previous research. We show that the baselines either fail to scale or incur an inordinate amount of overhead by failing to take advantage of natural properties of a data stream. By contrast, our strategy scales effortlessly for very large data streams. Moreover, it never performs more than a small constant times the optimal amount of work, regardless of the state of the data stream that may have led to Rout.
“The Road to Awesomeness”: The Environment, Language and Rhetoric in Chetan Bhagat’s Postcolonial India
Creators: name: Adami, Esterino
Publisher: name: Fondazione Università Ca’ Foscari Venezia, Italia
Year: 2020

description:

This paper aims to discuss how environment, language and rhetoric interplay in the postcolonial context, in particular by focusing on Making India Awesome (2015), a recent collection of essays in which journalist and novelist Chetan Bhagat offers suggestions to handle many of the challenges of India, ideally positioning the country ‘on the road to awesomeness’. Although ecology is not specifically treated, it obviously constitutes the backdrop of the themes of the book as it intertwines with broad social and cultural domains. I will look at the postcolonial environmental intertext, and its ideological implications, which the author builds up via specific frames, metaphors and devices from an interdisciplinary perspective informed by postcolonial critique, environmental humanities and ecolinguistics. The purpose of the analysis thus is to provide a critical reflection on how language shapes, creates and hides values at the interface between the postcolonial and the environmental.

description: Il Tolomeo
Distinct von Hippel-Lindau gene and hypoxia-regulated alterations in gene and protein expression patterns of renal cell carcinoma and their effects on metabolism.
Creators: name: Leisz, Sandra
name: Schulz, Kristin
name: Erb, Susanne
name: Oefner, Peter J.
name: Dettmer, Katja
name: Mougiakakos, Dimitrios
name: Wang, Ena
name: Marincola, Francesco M.
name: Stehle, Franziska
name: Seliger, Barbara
Publisher: name: Universität Regensburg
Year: 2015
Subjects: subject: hypoxia, von Hippel Lindau gene, renal cell carcinoma, cell metabolism, aerobic glycolysis
subject: 610 Medizin

description: During the last decade the knowledge about the molecular mechanisms of the cellular adaption to hypoxia and the function of the ``von Hippel Lindau'' (VHL) protein in renal cell carcinoma (RCC) has increased, but there exists little information about the overlap and differences in gene/protein expression of both processes. Therefore the aim of this study was to dissect VHL- and hypoxia-regulated alterations in the metabolism of human RCC using ome-based strategies. The effect of the VHL- and hypoxia-regulated altered gene/protein expression pattern on the cellular metabolism was analyzed by determination of glucose uptake, lactate secretion, extracellular pH, lactate dehydrogenase activity, amino acid content and ATP levels. By employing VHL-/VHL(+) RCC cells cultured under normoxic and hypoxic conditions, VHL-dependent, HIF-dependent as well as VHL-/HIF-independent alterations in the gene and protein expression patterns were identified and further validated in other RCC cell lines. The genes/proteins differentially expressed under these distinct conditions were mainly involved in the cellular metabolism, which was accompanied by an altered metabolism as well as changes in the abundance of amino acids in VHL-deficient cells. In conclusion, the study reveals similarities, but also differences in the genes and proteins controlled by VHL functionality and hypoxia thereby demonstrating differences in the metabolic switch of RCC under these conditions.
Clinical and pathological features of Burkitt lymphoma showing expression of BCL2 - an analysis including gene expression in formalin-fixed paraffin-embedded tissue
Creators: name: Masqué-Soler, Neus
name: Szczepanowski, Monika
name: Kohler, Christian W.
name: Aukema, Sietse M.
name: Nagel, Inga
name: Richter, Julia
name: Siebert, Reiner
name: Spang, Rainer
name: Burkhardt, Birgit
name: Klapper, Wolfram
Publisher: name: Universität Regensburg
Year: 2015
Subjects: subject: NanoString;nCounter;classifier;Burkitt;diffuse large B-cell lymphoma;MYC
subject: 004 Informatik
subject: 570 Biowissenschaften, Biologie
subject: 610 Medizin

description: The differential diagnosis between Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) can be challenging. BL has been reported to express less BCL2 than DLBCL, but this issue has not been analysed systematically. BL expressing BCL2 can be considered to be MYC/BCL2 co-expressors, a feature that is associated with poorer outcome in DLBCL but that has not been correlated with outcome in BL so far. We analysed the expression of BCL2 in 150 cases of conventionally diagnosed BL using two different BCL2 antibodies. BCL2 expression was detected in 23% of the cases, though the expression varied in intensity and number of positive cells. We did not detect any relevant differences in clinical presentation and outcome between BCL2-positive and BCL2-negative BL in a subgroup of 43 cases for which detailed clinical data were available. An independent cohort of 17 BL with expression of BCL2 were analysed molecularly, with 13 of 17 cases classified as molecularly defined BL (Burkitt Lymphoma) using gene expression profiling on formalin-fixed paraffin-embedded tissues. The four lymphomas diagnosed molecularly as intermediates did not differ in clinical presentation and outcome from molecularly defined BL.
Decolonizing the Anthropocene: ‘Slow Violence’ and Indigenous Resistance in Cherie Dimaline’s The Marrow Thieves
Creators: name: Xausa, Chiara
Publisher: name: Fondazione Università Ca’ Foscari Venezia, Italia
Year: 2020

description:

Through a reading of Cherie Dimaline’s 2017 young adult novel The Marrow Thieves, a survival story set in a futuristic Canada destroyed by global warming, this article explores the conceptualization and reimagination of the Anthropocene in contemporary postcolonial and Indigenous theory and fiction. Firstly, I will argue that literary representations of climate change can be complicit in producing hegemonic strands of Anthropocene discourse that consider human destructiveness and vulnerability at undifferentiated species level. Secondly, I will suggest that the novel’s apocalypse reveals the processes of colonial violence and dispossession that have culminated in the eruptive event of environmental catastrophe, rather than portraying a story of universal and disembodied human threat that conceals oppression against Indigenous people.

description: Il Tolomeo
Exploring binding stability of hydroxy-3-(4-hydroxyphenyl)-5-(4-nitrophenyl)-5,5a,7,8,9,9a-hexahydrothiazolo[2,3-b] quinazolin-6-one with T790M/L858R EGFR-TKD
Creators: name: Mir, Showkat Ahmad
name: Nayak, Binata
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Cancer causes innumerable deaths every year globally. Breast cancer and non-small cell lung carcinoma are the most prevalent worldwide. EGFR-TKD is a neoplastic survival therapeutic target in a wide array of carcinoma cells. Various non-specific tyrosine kinase inhibitors lead to hyperphosphorylation and overexpression of EGFR-TKD and further mutations recognise deletion of exon 19. In this work, we study the binding affinity, binding stability, and strength of hydroxy-3-(4-hydroxyphenyl)-5-(4-nitrophenyl)-5,5a,7,8,9,9a-hexahydrothiazolo[2,3-b] quinazolin-6-one with TMLR mutated EGFR-TKD (T790M/L858R). The collective motions, residual mobility, and flexibility of TMLR mutated EGFR-TKD bound with reference and title molecule were calculated by principal component analysis. The meta-state conformations of both the simulated complexes were determined by Gibb’s energy landscape analysis. The binding affinity exhibited by thiazolo-[2,3-b] quinazolinone and the reference molecule was found to be −7.95 ± 0.088 Kcal/mol and −9.13 ± 0.018 kcal/mol with TMLR mutated EGFR-TKD. The alignment of both the docked complexes was done by blosum40 matrix. Similar spatial orientations were exhibited by the synthesised ligand in the binding pocket of TMLR mutated EGFR-TKD, corresponding to the reference ligand. The ligand stability was computed for 100 ns. In addition, the radius of gyration, solvent accessible surface area, hydrogen bonds formed was calculated. The average ΔGbind of thiazolo-[2,3-b] quinazolinone was −41.212 ± 0.834 kJ/mol and for reference ligand −71.938 ± 0.367 kJ/mol, calculated by MM-PBSA. ADMET analysis concludes thiazolo-[2,3-b] quinazolinone derivative is safe. Further research work is encouraged to determine the efficacy of thiazolo-[2,3-b] quinazolinone against in vivo models. Communicated by Ramaswamy H. Sarma
Entanglement verification with finite data
Creators: name: Blume-Kohout, Robin
name: Yin, Jun O. S.
name: van Enk, S. J.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Suppose an experimentalist wishes to verify that his apparatus produces entangled quantum states. A finite amount of data cannot conclusively demonstrate entanglement, so drawing conclusions from real-world data requires statistical reasoning. We propose a reliable method to quantify the weight of evidence for (or against) entanglement, based on a likelihood ratio test. Our method is universal in that it can be applied to any sort of measurements. We demonstrate the method by applying it to two simulated experiments on two qubits. The first measures a single entanglement witness, while the second performs a tomographically complete measurement.
description: 4 pages, 3 pretty pictures
Molecular insights of hyaluronic acid – ethambutol and hyaluronic acid – isoniazid drug conjugates act as promising novel drugs for the treatment of tuberculosis
Creators: name: Thirumalaisamy, R.
name: Aroulmoji, V.
name: Iqbal, Muhammad Nasir
name: Saride, Shreyas
name: Bhuvaneswari, M.
name: Deepa, M.
name: Sivasankar, C.
name: Khan, Riaz
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: The present study examines cellular targeted drug delivery (CTDD) pattern of two novel Hyaluronic acid (HA) Tuberculosis Drug (TB) conjugates and its efficacy and strong binding affinity towards TB molecular protein targets. Two TB drugs ethambutol (EB) and isoniazid (IN) and their Hyaluronic acid conjugates (HA-EB & HA-IN) were tested for its metabolism, toxicity and excretion prediction through In silico tools they revealed hyaluronic acid conjugate of two TB drugs exhibited good drug profile over their free form of TB drugs. Further these four molecules subjected to In silico molecular docking study with four potential Mycobacterium tuberculosis target proteins (3PD8, 4Y0L, 5DZK and 6GAU). Molecular docking study revealed that hyaluronic conjugates (HA-EB & HA-IN) exhibit significant binding affinity and excellent docking scores with all screened molecular protein targets of TB over their free form of drug. Further molecular dynamic simulation was calculated for the four drug molecules (EB, IN, HA- EB & HA-IN) with DNA gyrase enzyme (PDB ID 6GAU) of Mycobacterium tuberculosis and the MDS results revealed that both the conjugates with the TB target protein possessed good number of interaction with binding pocket residues and good simulation scores than the free form of drugs. Communicated by Ramaswamy H. Sarma
Interaction of cCMP with the cGK, cAK and MAPK Kinases in Murine Tissues.
Creators: name: Wolfertstetter, Stefanie
name: Reinders, Jörg
name: Schwede, Frank
name: Ruth, Peter
name: Schinner, Elisabeth
name: Schlossmann, Jens
Publisher: name: Universität Regensburg
Year: 2015
Subjects: subject: 610 Medizin
subject: 615 Pharmazie

description: cAMP and cGMP are well established second messengers that are essential for numerous (patho)physiological processes. These purine cyclic nucleotides activate cAK and cGK, respectively. Recently, the existence of cCMP was described, and a possible function for this cyclic nucleotide was investigated. It was postulated that cCMP plays a role as a second messenger. However, the functions regulated by cCMP are mostly unknown. To elucidate probable functions, cCMP-binding and -activated proteins were identified using different methods. We investigated the effect of cCMP on purified cyclic nucleotide-dependent protein kinases and lung and jejunum tissues of wild type (WT), cGKI-knockout (cGKI KO) and cGKII-knockout (cGKII KO) mice. The catalytic activity of protein kinases was measured by a (γ-32P) ATP kinase assay. Cyclic nucleotide-dependent protein kinases (cAK, cGKI and cGKII) in WT tissue lysates were stimulated by cCMP. In contrast, there was no stimulation of phosphorylation in KO tissue lysates. Competitive binding assays identified cAK, cGKI, and cGKII as cCMP-binding proteins. An interaction between cCMP/MAPK and a protein-protein complex of MAPK/cGK were detected via cCMP affinity chromatography and co-immunoprecipitation, respectively. These complexes were abolished or reduced in jejunum tissues from cGKI KO or cGKII KO mice. In contrast, these complexes were observed in the lung tissues from WT, cGKI KO and cGKII KO mice. Moreover, cCMP was also able to stimulate the phosphorylation of MAPK. These results suggest that MAPK signaling is regulated by cGMP-dependent protein kinases upon activation by cCMP. Based on these results, we propose that additional cCMP-dependent protein kinases that are capable of modulating MAPK signaling could exist. Hence, cCMP could potentially act as a second messenger in the cAK/cGK and MAPK signaling pathways and play an important role in physiological processes of the jejunum and lung.
Ha Jin’s Ecocritical Irony in the Stylistic Analysis of the Personal Pronouns in “A Tiger Fighter is Hard to Find”
Creators: name: Marinaro, Isabella
Publisher: name: Fondazione Università Ca’ Foscari Venezia, Italia
Year: 2020

description:

This paper aims at showing how stylistics and ecocriticism, both being strongly ‘centripetal’ and ‘interdisciplinary’ fields, can cooperate in the exploration of a literary text. This is the case of a short story written by the Chinese-American writer Ha Jin. Also thanks to the help of the digital analysis, the paper mainly focuses on the stylistic analysis of the personal pronouns and of the narrator’s point of view to show the stinging and subversive irony which pervades the narration of the vicissitudes of a Chinese TV film crew who is asked to shoot a scene where a muscular hero has to fight bare-handed against a real Siberian tiger. The analysis also aims to show how the story becomes the opportunity for the writer to depict the narrow frame of mind of the blind dictatorship of his homeland and its deplorable consequences on both humans and animals. Thus, the whole exploration, in the end, reveals the ecocritical lens through which Ha Jin narrates the story.

description: Il Tolomeo
A quantitative Approach for modelling the influence of currency of Information on decision-making under uncertainty
Creators: name: Heinrich, Bernd
name: Hristova, Diana
Publisher: name: Universität Regensburg
Year: 2016
Subjects: subject: information quality, decision-making, metric for currency, value of information, customer relationship management
subject: 330 Wirtschaft

description: Stored information, used to support decision-making, can be outdated. Existing metrics for currency provide an indication about the correspondence between this stored information and its real-world counterpart. In the case of low currency, this information cannot be effectively used to support decision-making, although the decision-maker can probably learn from it. Our first objective is to develop an extended metric referring to currency, which provides an indication about the real-world information at the time of measurement, based on the stored information. Thus, the decision can be adjusted and the value of the stored information increased. Therefore, as a second objective, we propose a quantitative approach for modelling the influence of currency on decision-making by extending the normative concept of the value of information. Finally, we demonstrate the relevance of our approach by applying it to two real-world scenarios from the field of sales management in customer relationship management.