cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Outcomes of transjugular intrahepatic portosystemic shunt using 12 mm diameter stent for portal hypertension with variceal bleeding
Creators: name: Abdel Aal, Ahmed
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Interventional vascular
subject: Liver
subject: CT-Angiography
subject: Shunts
subject: Cirrhosis

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Evaluate the efficacy and survival outcomes of transjugular intrahepatic portosystemic shunt (TIPS) creation using a 12-mm diameter Viatorr stent (Gore, Newark, DE) in cirrhotic patients with portal hypertension and variceal bleeding ( Fig. 1 ), (...
SADDLE: A Modular Design Automation Framework for Cluster Supercomputers and Data Centres
Creators: name: Solnushkin, Konstantin S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Computer and information sciences
subject: C.1.4; C.5.1; J.6; K.6.2

description: In this paper we present SADDLE, a modular framework for automated design of cluster supercomputers and data centres. In contrast with commonly used approaches that operate on logic gate level (Verilog, VHDL) or board level (such as EDA tools), SADDLE works at a much higher level of abstraction: its building blocks are ready-made servers, network switches, power supply systems and so on. Modular approach provides the potential to include low-level tools as elements of SADDLE's design workflow, moving towards the goal of electronic system level (ESL) design automation. Designs produced by SADDLE include project documentation items such as bills of materials and wiring diagrams, providing a formal specification of a computer system and streamlining assembly operations.
description: 13 pages, 2 figures, 1 table. The work was presented at the International Supercomputing Conference (ISC'14) in Leipzig, Germany
title: The role of elastography in evaluation for axillary lymph nodes of patients with breast cancer
Creators: name: Chang, Wanying
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Lymph nodes
subject: Elastography
subject: Ultrasound
subject: Diagnostic procedure

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Preoperative evaluation of axillary lymph nodes (ALNs) in patients with breast cancer is very important to the subsequent treatment. According to the NCCN (National Comprehensive Cancer Network) guidelines of breast cancer, fine-needle aspiration...
Design, Synthesis, and Structure−Activity Relationship, Molecular Modeling, and NMR Studies of a Series of Phenyl Alkyl Ketones as Highly Potent and Selective Phosphodiesterase-4 Inhibitors
Creators: name: Prestegard, James
name: Li, Minyong
name: Reid, Suazette
name: Wang, Huanchen
name: Wang, Binghe
name: Macnaughtan, Megan
name: Zheng, Shilong
name: Ke, Hengming
name: Kaur, Gurpreet
name: Yang, Xiaochuan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Phosphodiesterase 4 catalyzes the hydrolysis of cyclic AMP and is a target for the development of anti-inflammatory agents. We have designed and synthesized a series of phenyl alkyl ketones as PDE4 inhibitors. Among them, 13 compounds were identified as having submicromolar IC50 values. The most potent compounds have IC50 values of in the mid- to low-nanomolar range. Compound 5v also showed preference for PDE4 with selectivity of >2000-fold over PDE7, PDE9, PDE2, and PDE5. Docking of 5v, 5zf, and 5za into the binding pocket of the PDE4 catalytic domain revealed a similar binding profile to PDE4 with rolipram except that the fluorine atoms of the difluoromethyl groups of 5v, 5za, and 5zf are within a reasonable range for hydrogen bond formation with the amide hydrogen of Thr 333 and the long alkyl chain bears additional van der Waals interactions with His 160, Asp 318, and Tyr 159.
BOSHLANG'ICH SINFLARGA SHAXS VA NARSA BELGISINI BILDIRGAN SO'ZLARNI O'QITISHNING METODIK ASOSLARI
Creators: name: Iskandarova, Maftuna
Publisher: name: Zenodo
Year: 2025

description: Ushbu tezisda shaxs va narsa belgisini bildirgan so'zlar nima ekanligi haqida, boshlang‘ich sinf o‘quvchilariga ona tili darslarida shaxs va narsa belgisini bildirgan so'zlar  qanday oson tushuntirish usullari haqida so‘z yuritiladi.
A 3D vortex formed by trajectories of the Navier-Stokes equation
Creators: name: Wang, Peng
name: Wang, Xu-Ming
Publisher: name: figshare
Year: 2022
Subjects: subject: 29902 Complex Physical Systems
subject: FOS: Physical sciences

description: The 3D Navier-Stokes equation for incompressible fluid is resolved by using the Lie group analysis method. The solution shows a spiral vortex structure and some strange related aspects. There are two running modes of the vortex, up-spiral or down-spiral, and the modes are determined by the viscosity of fluid. The calculated z-directional curl of the velocity presents a zero-piercing, which indicates that the variation from the up-spiral structure to the down-spiral may correspond to the state change of the fluid from gas to liquid. In the corresponding parameter region, there is likely a so-called two-phase-coexistence of gas and liquid. Within the vortex, the dependence of the angle velocity of a mass particle on its radial position is dominated by a Gaussian-like curve in the plane of angle velocity versus radial position. This work provides a vivid description of the vortex that is in accordance with a real vortex structure.
Experimental investigations on granular flows
Creators: name: Carleo, Luigi
Publisher: name: Universita degli studi di Salerno
Year: 2019
Subjects: subject: ICAR/02 COSTRUZIONI IDRAULICHE E MARITTIME E IDROLOGIA
subject: Granular
subject: Flow
subject: Rheology

description: 2017 - 2018
description: Granular flows, such as debris avalanches, debris flows and rock avalanches, involve the rapid motion of granular mixtures consisting of sediments, water and air. They occur on steep slopes and in the hydrographic network and can effect anthropized areas causing damage to buildings, roads and, in the worst case, loss of human lives... [edited by Author]
title: Role of interventional radiology in endocrine diseases
Creators: name: Ng, Wing Ki
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Endocrine disorders
subject: Diagnostic procedure
subject: Catheter venography
subject: Interventional vascular

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To describe the technique and experience of venous sampling in endocrinopathies in a regional hospital. Diagnostic procedures performed include inferior petrosal venous sampling in diagnosing pituitary microadenoma, adrenal venous sampling in...
title: May-Turner syndrome in men with a recurrent varicocele.
Creators: name: Zhukov, Oleg
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Pelvic floor dysfunction
subject: Pathology
subject: Stents
subject: Catheters
subject: Angioplasty
subject: Ultrasound-Colour Doppler
subject: Image manipulation / Reconstruction
subject: CT-Angiography
subject: Vascular
subject: Pelvis
subject: Interventional vascular
subject: Ischaemia / Infarction

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Purpose. The creation of a single algorithm of radiological diagnosis in patients with recurrent...
Constraining properties of GRB magnetar central engines using the observed plateau luminosity and duration correlation
Creators: name: Rowlinson, A.
name: Gompertz, B. P.
name: Dainotti, M.
name: O'Brien, P. T.
name: Wijers, R. A. M. J.
name: van der Horst, A. J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: An intrinsic correlation has been identified between the luminosity and duration of plateaus in the X-ray afterglows of Gamma-Ray Bursts (GRBs; Dainotti et al. 2008), suggesting a central engine origin. The magnetar central engine model predicts an observable plateau phase, with plateau durations and luminosities being determined by the magnetic fields and spin periods of the newly formed magnetar. This paper analytically shows that the magnetar central engine model can explain, within the 1$σ$ uncertainties, the correlation between plateau luminosity and duration. The observed scatter in the correlation most likely originates in the spread of initial spin periods of the newly formed magnetar and provides an estimate of the maximum spin period of ~35 ms (assuming a constant mass, efficiency and beaming across the GRB sample). Additionally, by combining the observed data and simulations, we show that the magnetar emission is most likely narrowly beamed and has $\lesssim$20% efficiency in conversion of rotational energy from the magnetar into the observed plateau luminosity. The beaming angles and efficiencies obtained by this method are fully consistent with both predicted and observed values. We find that Short GRBs and Short GRBs with Extended Emission lie on the same correlation but are statistically inconsistent with being drawn from the same distribution as Long GRBs, this is consistent with them having a wider beaming angle than Long GRBs.
description: MNRAS Accepted
Development and Preclinical Studies of Broad-Spectrum Anti-HIV Agent (3′ R ,4′ R )-3-Cyanomethyl-4-methyl-3′,4′-di- O -( S )-camphanoyl-(+)- cis -khellactone (3-Cyanomethyl-4-methyl-DCK)
Creators: name: Zhang, An-Ming
name: Wu, Gang
name: Jiang, Shibo
name: Zhuang, Xiao-Mei
name: Ruan, Jin-Xiu
name: Lee, Kuo-Hsiung
name: Lu, Hong
name: Xie, Lan
name: Yu, Donglei
name: Guo, Huan-Fang
name: Zhou, Ting
name: Qian, Keduo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: In prior investigation, we discovered that (3'R,4'R)-3-cyanomethyl-4-methyl-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (4, 3-cyanomethyl-4-methyl-DCK) showed promising anti-HIV activity. In these current studies, we developed and optimized successfully a practical ten-step synthesis for scale-up preparation to increase the overall yield of 4 from 7.8% to 32%. Furthermore, compound 4 exhibited broad-spectrum anti-HIV activity against wild-type and drug-resistant viral infection of CD4+ T cell lines as well as peripheral blood mononuclear cells by both laboratory-adapted and primary HIV-1 isolates with distinct subtypes and tropisms. Compound 4 was further subjected to in vitro and in vivo pharmacokinetic studies. These studies indicated that 4 has moderate cell permeability, moderate oral bioavailability and low systemic clearance. These results suggest that 4 should be developed as a promising anti-HIV agent for development as a clinical trial candidate.
Additional file 3 of The Workwell trial: protocol for the process evaluation of a randomised controlled trial of job retention vocational rehabilitation for employed people with inflammatory arthritis
Creators: name: Hammond, Alison
name: Radford, Kathryn A.
name: Ching, Angela
name: Prior, Yeliz
name: O’Brien, Rachel
name: Woodbridge, Sarah
name: Culley, June
name: Parker, Jennifer
name: Holland, Paula
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Additional file 3. Trial participants’ consent form.
Potential Modes of Interaction of 9-Aminomethyl-9,10-dihydroanthracene (AMDA) Derivatives with the 5-HT 2A Receptor: A Ligand Structure-Affinity Relationship, Receptor Mutagenesis and Receptor Modeling Investigation
Creators: name: Runyon, Scott P.
name: Glennon, Richard A.
name: Roth, Bryan L.
name: Westkaemper, Richard B.
name: Mosier, Philip D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The effects of 3-position substitution of 9-aminomethyl-9,10-dihydroanthracene (AMDA) on 5-HT2A receptor affinity were determined and compared to a parallel series of DOB-like 1-(2,5-dimethoxyphenyl)-2-aminopropanes substituted at the 4-position. The results were interpreted within the context of 5-HT2A receptor models that suggest that members of the DOB-like series can bind to the receptor in two distinct modes that correlate with the compounds’ functional activity. Automated ligand docking and molecular dynamics suggest that all of the AMDA derivatives, the parent of which is a 5-HT2A antagonist, bind in a fashion analogous to that for the sterically demanding antagonist DOB-like compounds. The failure of the F3406.52L mutation to adversely affect the affinity of AMDA and the 3-bromo derivative is consistent with the proposed modes of orientation. Evaluation of ligand-receptor complex models suggest that a valine/threonine exchange between the 5-HT2A and D2 receptors may be the origin of selectivity for AMDA and two substituted derivatives.
title: Influence of tumor subtype, radiological sign and prognostic factors on tumor size discrepancies between digital breast tomosynthesis and final histology.
Creators: name: Tagliafico, Alberto
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Breast
subject: Mammography
subject: Diagnostic procedure
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Introduction Accurate size prediction of an invasive breast cancer is important in preoperative planning, as a prognostic indicator and consequently for patient management (1). Although pathologic measurement is regarded as the gold...
Optomechanical photon shuttling between photonic cavities
Creators: name: Li, Huan
name: Li, Mo
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Mechanical motion of photonic devices driven by optical forces provides a profound means of coupling between optical fields. The current focus of these optomechanical effects has been on cavity optomechanics systems in which co-localized optical and mechanical modes interact strongly to enable wave-mixing between photons and phonons and backaction cooling of mechanical modes. Alternatively, extended mechanical modes can also induce strong nonlocal effects on propagating optical fields or multiple localized optical modes at distances. Here, we demonstrate a novel multi-cavity optomechanical device: a "photon see-saw", in which torsional optomechanical motion can shuttle photons between two photonic crystal nanocavities. The resonance frequencies of the two cavities, one on each side of the see-saw, are modulated anti-symmetrically by the device's rotation. Pumping photons into one cavity excites optomechanical self-oscillation which strongly modulates the inter-cavity coupling and shuttles photons to the other empty cavity during every oscillation cycle in a well regulated fashion.
description: 17 pages, 4 figures, submitted to Nature Nanotechnology
Electron Heating During Magnetic Reconnection: A Simulation Scaling Study
Creators: name: Shay, M. A.
name: Haggerty, C. C.
name: Phan, T. D.
name: Drake, J. F.
name: Cassak, P. A.
name: Wu, P.
name: Oieroset, M.
name: Swisdak, M.
name: Malakit, K.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: Electron bulk heating during magnetic reconnection with symmetric inflow conditions is examined using kinetic particle-in-cell (PIC) simulations. The degree of electron heating is well correlated with the inflowing Alfvén speed $c_{Ar}$ based on the reconnecting magnetic field through the relation $ΔT_e = 0.033 \,m_i\,c_{Ar}^2$, where $ΔT_{e}$ is the increase in electron temperature. For the range of simulations performed, the heating shows almost no correlation with inflow total temperature $T_{tot} = T_i + T_e$ or plasma $β$. An out-of-plane (guide) magnetic field of similar magnitude to the reconnecting field does not affect the total heating, but it does quench perpendicular heating, with almost all heating being in the parallel direction. These results are qualitatively consistent with a recent statistical survey of electron heating in the dayside magnetopause, which also found that $ΔT_e$ was proportional to the inflowing Alfvén speed. The net electron heating varies very little with distance downstream of the x-line. The simulations show at most a very weak dependence of electron heating on the ion to electron mass ratio. In the antiparallel reconnection case, the largely parallel heating is eventually isotropized downstream due a scattering mechanism such as stochastic particle motion or instabilities. The study highlights key properties that must be satisfied by an electron heating mechanism: (1) Preferential heating in the parallel direction; (2) Heating proportional to $m_i\,c_{Ar}^2$; (3) At most a weak dependence on electron mass; and (4) An exhaust electron temperature that varies little with distance from the x-line.
description: 27 pages, 1 table, 7 figures. Submitted to Physics of Plasmas
title: Locally advanced rectal cancer: the reliability of MRI tumour regression grade in assessing response to neoadjuvant combined radiation therapy with chemotherapy
Creators: name: Yang, lanqing
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Gastrointestinal tract
subject: Oncology
subject: MR
subject: MR-Diffusion/Perfusion
subject: Outcomes analysis
subject: Diagnostic procedure
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Neoadjuvant chemoradiotherapy (NCRT) following with total mesorectal excision a period later has become the standard of care for locally advanced rectal cancer (LARC).[1] Some patients can even achieve a pathological complete response (pCR) after...
Anti-AIDS Agents. 78. † Design, Synthesis, Metabolic Stability Assessment, and Antiviral Evaluation of Novel Betulinic Acid Derivatives as Potent Anti-Human Immunodeficiency Virus (HIV) Agents
Creators: name: Huang, Li
name: Reddick, Mary
name: Allaway, Graham P.
name: Chen, Chin-Ho
name: Nitz, Theodore J.
name: Salzwedel, Karl
name: Yu, Donglei
name: Morris-Natschke, Susan L.
name: Qian, Keduo
name: Lee, Kuo-Hsiung
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: In a continuing study of potent anti-HIV agents, seventeen 28,30-disubstituted betulinic acid (BA, 1) derivatives, as well as seven novel 3,28-disubstituted BA analogs were designed, synthesized, and evaluated for in vitro antiviral activity. Among them, compound 21 showed an improved solubility and equal anti-HIV potency (EC50: 0.09 μM), when compared to HIV entry inhibitors 3b (IC9564) and 4 (A43-D). Using a cyclic secondary amine to form the C-28 amide bond increased the metabolic stability of the derivatives significantly in pooled human liver microsomes. The most potent compounds 47 and 48 displayed potent anti-HIV activity with EC50 values of 0.007 μM and 0.006 μM, respectively. These results are slightly better than that of bevirimat (2), which is currently in Phase IIb clinical trials. Compounds 47 and 48 should serve as attractive promising leads to develop next generation, metabolically stable, 3,28-disubstituted bifunctional HIV-1 inhibitors as clinical trials candidates.
Antiseizure Activity of Novel γ-Aminobutyric Acid (A) Receptor Subtype-Selective Benzodiazepine Analogues in Mice and Rat Models
Creators: name: Furtmüller, Roman
name: Roth, Bryan L.
name: Murphree, Lauren
name: Edwankar, Chitra R.
name: Sankar, Subramanian
name: Huang, Shengming
name: Sieghart, Werner
name: Jain, Hiteshkumar D.
name: Stables, James P.
name: Cook, James M.
name: Edwankar, Rahul V.
name: Rivas, Felix M.
name: Zhou, Hao
name: Majumder, Samarpan
name: Ramerstorfer, Joachim
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The antiseizure activity of benzodiazepines (BDZs) 1-5 in mice and rats as animal models is described. These BDZs have selective efficacy for α2β3γ2 and α3β3γ2 GABAA-receptors. Significant anticonvulsant activity with little or no motor impairment and therapeutic indexes (TI) of 2.8-44 (mice, ip) were observed for compounds 2-4 in the subcutaneous metrazole seizure (scMET) test. In rats orally (po) the TI was >5 to 105. These compounds represent novel leads in the search for anticonvulsants devoid of sedative, ataxic and amnestic side effects.
Integral Method for Gratings
Creators: name: Maystre, Daniel
name: Popov, Evgeny
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optics (physics.optics)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: The chapter contains a detailed presentation of the surface integral theory for modelling light diffraction by surface-relief diffraction gratings having a one-dimensional periodicity. Several different approaches are presented, leading either to a single integral equation, or to a system of coupled integral equations. Special attention is paid to the singularities of the kernels, and to different techniques to accelerate the convergence of the numerical computations. The theory is applied to gratings having different profiles with or without edges, to real metal and dielectrics, and to perfectly conducting substrates.
description: www.fresnel.fr/numerical-grating-book-2
Additional file 4 of The Workwell trial: protocol for the process evaluation of a randomised controlled trial of job retention vocational rehabilitation for employed people with inflammatory arthritis
Creators: name: Hammond, Alison
name: Radford, Kathryn A.
name: Ching, Angela
name: Prior, Yeliz
name: O’Brien, Rachel
name: Woodbridge, Sarah
name: Culley, June
name: Parker, Jennifer
name: Holland, Paula
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Additional file 4. Workwell trial: NPT constructs mapped to participants and employer topic guide.
Sistemi informativi intelligenti a supporto di passeggeri di un terminal aeroportuale: contenuti informativi, modelli di propensione all’uso, modelli di reazione all’informazione e specificazione di un ambiente di simulazione dinamico
Creators: name: Elia, Luigi
Publisher: name: Universita degli studi di Salerno
Year: 2018
Subjects: subject: ICAR/05 TRASPORTI
subject: Aeroporto
subject: Scelte
subject: Simulazione

description: 2016 - 2017
description: Over the last fifty years, world air transportation has undergone an extraordinary increase, much higher than other transport modes has been observed a profound transformation of the field. Nowadays, a new model of airport management company is emerging, following the idea that a commercial airport has to tend to the continuous improvement of services and activities, but it should aim to add value not only to aviation revenues, but also to revenues deriving from non-aviation activities. Currently, one of the main goal of airport operator is to ensure an adequate level of service in terms of travel times, movement spaces, information services, costs related to the management of internal resources, commercial revenues, with a view to wider competition and economic sustainability. In airport management, therefore, it becomes increasingly important the ability to create innovation and produce knowledge. Such aim can be achieved thanks to Information and communication technologies. In such scenario, four issues seem to be relevant: • The understanding of the potential willingness to use advanced and intelligent information systems in order to support the movement homeairport- boarding gate; • The analysis and simulation of willingness to pay for getting advanced and intelligent information systems; • The analysis and simulation of passenger behavior in the presence of information systems designed to reduce waiting times and travel experience; • The validation and implementation of behavioral logics of airport passengers in presence of advanced information systems. ... [edited by Author]
Extraction of Multi-layered Social Networks from Activity Data
Creators: name: Musial, Katarzyna
name: Bródka, Piotr
name: Kazienko, Przemysław
name: Gaworecki, Jarosław
Publisher: name: arXiv
Year: 2014
Subjects: subject: Social and Information Networks (cs.SI)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: The data gathered in all kind of web-based systems, which enable users to interact with each other, provides an opportunity to extract social networks that consist of people and relationships between them. The emerging structures are very complex due to the number and type of discovered connections. In webbased systems, the characteristic element of each interaction between users is that there is always an object that serves as a communication medium. This can be e.g. an email sent from one user to another or post at the forum authored by one user and commented by others. Based on these objects and activities that users perform towards them, different kinds of relationships can be identified and extracted. Additional challenge arises from the fact that hierarchies can exist between objects, e.g. a forum consists of one or more groups of topics, and each of them contains topics that finally include posts. In this paper, we propose a new method for creation of multi-layered social network based on the data about users activities towards different types of objects between which the hierarchy exists. Due to the flattening, preprocessing procedure new layers and new relationships in the multi-layered social network can be identified and analysed.
description: 20 pages, 15 figures
title: Comparative analysis of effective risk for fixed tube current (FTC) and automatic tube current modulation (ACTM) during abdominal CT imaging
Creators: name: Hogg, Peter
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Radioprotection / Radiation dose
subject: Radiographers
subject: Radiation physics
subject: CT
subject: Dosimetry
subject: Radiation safety
subject: Radiation effects

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The risk of inducing cancer as a result of exposure to ionizing radiation is a cause for concern in medical imaging [1]. The number of CT procedures carried out has increased significantly over the last decade and reasons such as the need for cancer...
Antitumor Agents 268. Design, Synthesis, and Mechanistic Studies of New 9-Substituted Phenanthrene-Based Tylophorine Analogues as Potent Cytotoxic Agents
Creators: name: Lin, Jau-Chen
name: Yang, Shuenn-Chen
name: Yang, Pan-Chyr
name: Zhao, Guiyu
name: Yang, Xiaoming
name: Shi, Qian
name: Lee, Kuo-Hsiung
name: Bastow, Kenneth F.
name: Liu, Yi-Nan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Nineteen new phenanthrene-based tylophorine analogs with various functional groups on the piperidine moiety were designed, synthesized and evaluated for in vitro anticancer activity against four human tumor cell lines. Analogs 15 and 21 showed approximately two-fold enhanced inhibitory activity as compared with our prior lead compound (PBT-1). Analogs 23 and 24 with S- and R-configured substituents, respectively, at the piperidine 3’-position exhibited comparable cytotoxicity to that of PBT-1. Furthermore, mechanistic studies to investigate the effects of the new compounds on Akt protein in lung cancer cells and the NF-kB signaling pathway suggested that the compounds may exert their inhibitory activity on tumor cells through inhibition of activation of both Akt and NF-kB signaling pathway.
Photon-assisted tunneling with non-classical light
Creators: name: Souquet, J. -R.
name: Woolley, M. J.
name: Gabelli, Julien
name: Simon, Pascal
name: Clerk, Aashish A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Among the most exciting recent advances in the field of superconducting quantum circuits is the ability to coherently couple microwave photons in low-loss cavities to quantum electronic conductors (e.g.~semiconductor quantum dots or carbon nanotubes). These hybrid quantum systems hold great promise for quantum information processing applications; even more strikingly, they enable exploration of completely new physical regimes. Here we study theoretically the new physics emerging when a quantum electronic conductor is exposed to non-classical microwaves (e.g.~squeezed states, Fock states). We study this interplay in the experimentally-relevant situation where a superconducting microwave cavity is coupled to a conductor in the tunneling regime. We find the quantum conductor acts as a non-trivial probe of the microwave state; in particular, the emission and absorption of photons by the conductor is characterized by a non-positive definite quasi-probability distribution. This negativity has a direct influence on the conductance of the conductor.
description: 8 pages, 5 figures; Supplementary Information: 12 pages 8 figures
title: Postcontrast 3D T1 TFE m-Dixon sequence with multiplanar reconstructions can be used for the reliable detection of pathologies in brain and head and neck.
Creators: name: Sartoretti-Schefer, Sabine
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Education and training
subject: Diagnostic procedure
subject: MR
subject: Ear / Nose / Throat
subject: CNS

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The postcontrast 3D m-Dixon T1w turbo field echo (TFE) sequence, obtained on a 1.5 T Philips MR scanner, allows a reliable detection of pathologic lesions in brain parenchyma, meninges, neurocranium and viscerocranium and soft tissues of the head...
Antitumor Agents. 266. Design, Synthesis, and Biological Evaluation of Novel 2-(Furan-2-yl)naphthalen-1-ol Derivatives as Potent and Selective Antibreast Cancer Agents
Creators: name: Bastow, Kenneth F.
name: Shi, Qian
name: Wang, Xiang
name: Dong, Yizhou
name: Lee, Kuo-Hsiung
name: Liu, Yi-Nan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: In a continuing study, we explored how the individual rings in neo-tanshinlactone (1) influence its potent and selective in vitro anti-breast cancer activity. Accordingly, we discovered a novel class of anti-breast cancer agents, 2-(furan-2-yl) naphthalen-1-ol derivatives, based on an active C-ring opened model compound 5. Further optimization led to 18 and 21, which showed decreased cytotoxic potency, but better selectivity than neo-tanshinlactone analog 2. Interestingly, compound 20 showed broad cytotoxicity against human cancer cell lines.
title: Rare cases of external hernias and differential diagnosis
Creators: name: Uchida, Aoi
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Hernia
subject: Diagnostic procedure
subject: CT
subject: Gastrointestinal tract
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To learn about the points and pitfalls that may be encountered during the diagnosis of rare external...
title: Patient dose reduction combining tomosynthesis with synthetic instead of standard mammography
Creators: name: Gennaro, Gisella
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Breast
subject: Radiation physics
subject: Mammography
subject: Dosimetry

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Background Clinical evidence about benefits of using digital breast tomosynthesis (DBT) in screening application has been mainly obtained comparing clinical performance of standard mammography alone (FFDM) with the combinations of DBT and FFDM [ 1 ,...
Betulinic Acid Derivatives as Human Immunodeficiency Virus Type 2 (HIV-2) Inhibitors ∥
Creators: name: Qian, Keduo
name: Huang, Li
name: Lee, Kuo-Hsiung
name: Chen, Chin-Ho
name: Dang, Zhao
name: Lai, Weihong
name: Ho, Phong
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: We previously reported that [[N-[3β-hydroxyl-lup-20(29)-en-28-oyl]-7-aminoheptyl]-carbamoyl]methane (A43D, 4) was a potent HIV-1 entry inhibitor. However, 4 was inactive against HIV-2 virus, suggesting the structural requirements for targeting these two retroviruses are different. In this study, a series of new betulinic acid derivatives were synthesized, and some of them displayed selective anti-HIV-2 activity at nanomolar concentrations. In comparison to compounds with anti-HIV-1 activity, a shorter C-28 side chain is required for optimal anti-HIV-2 activity.
Slow relaxation of cascade-induced defects in Fe
Creators: name: Béland, Laurent Karim
name: Osetskiy, Yuri
name: Stoller, Roger E.
name: Xu, Haixuan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: On-the-fly kinetic Monte Carlo (KMC) simulations are performed to investigate slow relaxation of non-equilibrium systems. Point defects induced by 25 keV cascades in $α$-Fe are shown to lead to a characteristic time-evolution, described by the \emph{replenish and relax} mechanism. Then, we produce an atomistically-based assessment of models proposed to explain the slow structural relaxation by focusing on the aggregation of 50 vacancies and 25 self-interstital atoms (SIA) in 10-lattice-parameter $α$-Fe boxes, two processes that are closely related to cascade annealing and exhibit similar time signature. Four atomistic effects explain the timescales involved in the evolution: defect concentration heterogeneities, concentration-enhanced mobility, cluster-size dependent bond energies and defect-induced pressure. These findings suggest that the two main classes of models to explain slow structural relaxation, the Eyring model and the Gibbs model, both play a role to limit the rate of relaxation of these simple point-defect systems.
LGBTQIA+ Family Planning and Parenthood in South East Asia: A Scoping Review
Creators: name: Lin, Jing Wen
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: Social and Behavioral Sciences
subject: LGBT
subject: Parenting
subject: South East Asia

description: This scoping review aims to explore the existing literature regarding LGBTQIA+ family planning and parenthood in South East Asia and provide recommendations for future practices and research. This is a scoping review protocol.
Migration Policies of the European Union and Turkey with special Consideration of the 2016 Readmission Agreement
Creators: name: Sinik, Ayse Aysu
Publisher: name: Universita' degli Studi di Salerno
Year: 2020
Subjects: European Union
Turkey
Immigration Policies
EU-Turkey Readmission Agreement

description: In the second half of the twentieth century, an increase in the rate of irregular migration was observed, caused by conflicts that threatened human life. Since the 1990s, the EU has developed various mechanisms to control external migration. In the 1990s and later, there have been more migrants to Europe than in previous periods. This situation caused the European Union to develop a policy of common strength. At the same time, Turkey became a significant country with respect to migration routes, being situated between Europe and the home countries of most migrants since the 1990s: the former Soviet countries and the Middle East. This research contribution aims at examining and analyzing the foreign and immigration policies of the European Union and Turkey. It will examine not only the internal policies on the migration of both the European Union and Turkey but also the relationship between these two sides, especially after 2011 with the beginning of the Syrian civil war and the movements of forced migration. In particular, this paper will focus on the EU-Turkey Readmission Agreement of March 2016
Additional file 5 of The Workwell trial: protocol for the process evaluation of a randomised controlled trial of job retention vocational rehabilitation for employed people with inflammatory arthritis
Creators: name: Hammond, Alison
name: Radford, Kathryn A.
name: Ching, Angela
name: Prior, Yeliz
name: O’Brien, Rachel
name: Woodbridge, Sarah
name: Culley, June
name: Parker, Jennifer
name: Holland, Paula
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: Additional file 5. Workwell trial: NPT constructs mapped to therapist topic guide.
Design and Synthesis of 2-(3-Benzo[ b ]thienyl)-6,7-methylenedioxyquinolin-4-one Analogues as Potent Antitumor Agents that Inhibit Tubulin Assembly
Creators: name: Wang, Sheng-Hung
name: Morris-Natschke, Susan L.
name: Hamel, Ernest
name: Chang, Yu-Hsun
name: Lee, Kuo-Hsiung
name: Huang, Li-Jiau
name: Kuo, Sheng-Chu
name: Qian, Keduo
name: Hsu, Mei-Hua
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: As part of our continuing investigation of azo-flavonoid derivatives as potential anticancer drug candidates, a series of 2-aryl-6,7-methylenedioxyquinolin-4-one analogs was designed and synthesized. The design combined structural features of 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one (CHM-1), a previously discovered compound with potent in vivo antitumor activity, and 2-arylquinolin-4-ones identified by CoMFA models. The newly synthesized analogs were evaluated for cytotoxicity against seven human cancer cell lines, and structure-activity relationship (SAR) correlations were established. Analogs 1, 37, and 39 showed potent cytotoxicity against different cancer cell lines. Compound 1 demonstrated selective cytotoxicity against Hep 3B (hepatoma) cells. Compound 37 was cytotoxic against HL-60 (leukemia), HCT-116 (colon cancer), Hep 3B (hepatoma), and SK-MEL-5 (melanoma) cells. Compound 39 exhibited broad cytotoxicity against all seven cancer cell lines, with IC50 values between 0.07–0.19 µM. Results from mechanism of action studies revealed that these new quinolone derivatives function as antitubulin agents.
Metacognitive accuracy in detecting political misinformation #1
Creators: name: Geers, Michael
name: Fischer, Helen
name: Lewandowsky, Stephan
name: Herzog, Stefan
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Psychology
subject: FOS: Psychology
subject: Cognitive Psychology
subject: Social and Behavioral Sciences
subject: metacognition
subject: misinformation
subject: politics
subject: social media

description: This is the preregistration of a secondary data analysis exploring citizens' metacognitive accuracy in detecting political misinformation. It is the first step of a two-step preregistration procedure where the second step will be the preregistration of the actual analysis code.
title: CT guided Radiofrequency ablation as an effective treatment for osteoid osteoma
Creators: name: Seyam, Omnia
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Bones
subject: Paediatric
subject: Interventional non-vascular
subject: CT
subject: Ablation procedures
subject: Biopsy
subject: Neoplasia
subject: Outcomes

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Diagnosis of osteoid osteoma Technique of CT guided Radiofrequency ablation; RF of osteoid osteoma Eﬃcacy of RF ablation in treating osteoid...
title: The oxidation and carburisation of Fe-9%Cr-1%Mo steel
Creators: name: G. Baxter, A.
Publisher: name: University of Liverpool Repository
Year: 2023

description: The mechanisms involved in the breakdown of the protective ccides formed on Fe-9%Cr l%Mo have been investigated in both air and high pressure CO 2' The initial research programme was to investigate the microstructural changes which occurred with breakaway oxidation, a new EELS detector being cxi missioned to detenni. ne oxygen and raXbon levels. Oxidation in air was performed at temperatures between 500 and 1000'C. SEM and sane TEN cross sectional work was performed to determine the role of oxygen ingression, but prcblems in sample preparation made examination difficult. With cDcidation in high pressure OD2 the change from protective growth to breakaway is accanpanied by massive oxide growths usually at specimen corners. Microstructural changes also occur, with massive carbide growth acccrnpanying the changes in oxide structure. During oxidation, chemical exchanges between the oxidising gas, the metal and the inner oxide all contribute to the deposition of carbon at the metal/ oxide interface. This process generates internal stresses in the oxide, allowing microcracks to develop this enhancing the inward movement of the 002 and causing more, oxidation and carbon deposition. TEM cross sections were prepared to determine the mode of oxidation and the process by which carbon reaches the interface. In theory, EELS analysis allows identification of light elements Mi and above) but in practice the system proved very sample dependent, working well on thin films but very poorly on thick specimens (carbides). Evidence of the range of EELS mapping facilities are presented together with work on a new particle extraction system
title: Endovascular approach to pulmonary arteriovenous fistulae treatment.
Creators: name: Kuczyńska, Maryla
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Interventional vascular
subject: Lung
subject: Catheter arteriography
subject: Embolisation
subject: Arteriovenous malformations
subject: Fistula

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The aim of this presentation isto discuss the efficacy and technical details of the selected current approaches to PAVM treatment with respect to the angioarchitecture of the fistulae, based on the literature review and clinical...
Identifying Useful Statistical Indicators of Proximity to Instability in Stochastic Power Systems
Creators: name: Ghanavati, Goodarz
name: Hines, Paul D. H.
name: Lakoba, Taras I.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Physics and Society (physics.soc-ph)
subject: FOS: Physical sciences

description: Prior research has shown that autocorrelation and variance in voltage measurements tend to increase as power systems approach instability. This paper seeks to identify the conditions under which these statistical indicators provide reliable early warning of instability in power systems. First, the paper derives and validates a semi-analytical method for quickly calculating the expected variance and autocorrelation of all voltages and currents in an arbitrary power system model. Building on this approach, the paper describes the conditions under which filtering can be used to detect these signs in the presence of measurement noise. Finally, several experiments show which types of measurements are good indicators of proximity to instability for particular types of state changes. For example, increased variance in voltages can reliably indicate the location of increased stress, while growth of autocorrelation in certain line currents is a reliable indicator of system-wide instability.
description: 8 pages, 12 figures
title: Modified rapid contrast dynamic magnetic resonance in breast cancer diagnosis
Creators: name: Drinkovic, Martin
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Metastases
subject: Cancer
subject: Diagnostic procedure
subject: Barium meal
subject: MR
subject: Oncology
subject: Breast

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: 1. The purpose of this presentation is to present our modified MRI protocol, which we use when screening women under suspicion of breast cancer after examining them with imaging methods such as the 3D mammography and ultrasound. 2. To describe the...
A temporally adaptive hybridized discontinuous Galerkin method for time-dependent compressible flows
Creators: name: Jaust, Alexander
name: Schütz, Jochen
Publisher: name: arXiv
Year: 2014
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: The potential of the hybridized discontinuous Galerkin (HDG) method has been recognized for the computation of stationary flows. Extending the method to time-dependent problems can, e.g., be done by backward difference formulae (BDF) or diagonally implicit Runge-Kutta (DIRK) methods. In this work, we investigate the use of embedded DIRK methods in an HDG solver, including the use of adaptive time-step control. Numerical results demonstrate the performance of the method for both linear and nonlinear (systems of) time-dependent convection-diffusion equations.
Effects of Cross-Age Peer Mentoring Program Within a Randomized Controlled Trial
Creators: name: Lass, Katherine
name: Jenner, Eric
name: Walsh, Sarah
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences

description: This project is a 2016 development grant funded by the Department of Education Investing in Innovation (i3) Program. Peer Group Connection High School (PGC-HS) is a school-based high school transition and cross-age peer mentoring program for ninth grade students that is designed to improve non-cognitive abilities (e.g., grit, decision making skills, goal-setting skills), student engagement, and educational outcomes. The program leverages existing resources, such as school staff, parents, and student leaders, in order to create a supportive environment for new high school students that encourages them to attend school, set personal goals, work hard, and make healthy decisions. By offering additional support to ninth grade students, the program seeks to mitigate problems that often are associated with the transition into high school, such as disengagement from school, absenteeism, and declines in academic performance. The study design is a student-level randomized control trial (RCT) designed to isolate the impact of PGC on two student-level drop-out prevention outcomes: staying in school and progressing in school. A regression analysis will estimate these effects while controlling for relevant covariates as well as the baseline measure of the outcome variable (or variables highly correlated with the outcome measure) to increase the precision of our estimates. Key research questions 1. Research Question 1: What is the impact of PGC (treatment) relative to the control condition (business as usual) on ninth grade participants' staying in school? 2. Research Question 2: What is the impact of PGC (treatment) relative to the control condition (business as usual) on ninth grade participants' progressing in school?