cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Engineering programmable trans-splicing riboregulators for complex cellular logic computation
Creators: name: Gao, Yuanli
Publisher: name: The University of Edinburgh
Year: 2025
Subjects: subject: Synthetic Biology
subject: Genetic circuit
subject: Intron
subject: Biocomputation
subject: RNA splicing

description: Synthetic genetic circuits program the cellular input-output relationships to execute customized functions. However, efforts to scale up these circuits have been hampered by the limited number of reliable regulatory mechanisms with high programmability, performance, predictability, and orthogonality. In this thesis, I engineered a class of Split-intron ENabled Trans-splicing Riboregulators (SENTRs) based on de-novo-designed external guide sequences (EGSs). SENTR libraries provide low leakage expression, wide dynamic range, and low crosstalk at multiple component levels. SENTRs can sense RNA targets, process signals by logic computation, and transduce them into various outputs, either mRNAs or ncRNAs. SENTR represents a powerful and versatile regulatory tool at the post-transcriptional level in Escherichia coli, with broad applications in biotechnology. I subsequently demonstrated that digital logic operation with up to six inputs could be implemented by using multiple orthogonal SENTRs to regulate a single gene simultaneously and coupling SENTRs with split intein-mediated protein trans-splicing. The integration of split introns and inteins is an efficient, genetically compact, and generally applicable strategy for building multi-input processing devices to significantly increase the information processing capacity of a single regulator gene.
title: Understanding the evolutionary constraints of the supershedding phenotype through experimental selection
Creators: name: Gonzalez Pena, Mariangel Del Carmen
Publisher: name: The University of Edinburgh
Year: 2025
Subjects: subject: supershedding phenotype
subject: pathogen shedding rates
subject: Supershedding
subject: Pseudomonas aeruginosa

description: Individual heterogeneity is an inherent characteristic of all natural populations. In the context of epidemiology, heterogeneity is notably expressed through individual variation in pathogen transmission rates across hosts. For many infectious diseases, this leads to a common observation known as the 20/80 rule, which describes that approximately 20% of infected individuals are responsible for at least 80% of the transmission events. Variation in pathogen shedding rates is a key physiological factor driving transmission heterogeneity. Supershedding refers to the phenomenon where certain individuals exhibit extreme shedding rates compared to the population average. Studying the behavioural and physiological characteristics associated with this group of high-risk individuals would be useful for early epidemic prevention, but is challenging due to the rarity of the phenotype in natural populations. To overcome this limitation, I developed, through artificial selection, a novel population of supershedding D. melanogaster. In each selection round, flies were orally infected with the generalist bacterial pathogen Pseudomonas aeruginosa and allowed to shed the pathogen for 18 hours. In each round of selection, offspring from the top 10% of flies with the highest CFU counts were selected. After ten rounds of selection, this protocol successfully yielded a fly population exhibiting a 3-fold increase in the mean shedding compared to the original population. During the project's second stage, I conducted various assays to examine the direct and correlated responses to selection, including the daily variation in pathogen shedding, the internal pathogen load, faecal excretion, infected survival and healthy lifespan. Our findings show that pathogen shedding in D. melanogaster exhibits the same features of shedding in many infectious diseases. We describe population-level heterogeneity in pathogen shedding showing zero-inflation and significant overdispersion, where a significant fraction (~20%) showed no shedding while the top 20% of shedders were responsible for over 90% of the pathogen shed. We also observed that artificial selection could increase the pathogen shedding rates, suggesting a heritable genetic component to pathogen shedding. Moreover, we observed that the newly selected population displayed a sexually dimorphic response to selection, as selected females, but not males, exhibited significantly lower survival and longevity compared to the ancestral population. This early foundational work establishes the importance of a small portion of individuals in the spread of a pathogen, while the novel selection lines offer a valuable resource for future research exploring the genetic and physiological basis of extreme transmission phenotypes.
title: Developing functional complementation and variant screening assays in yeast for deep mutational scanning of mitochondrial aldehyde dehydrogenase ALDH2
Creators: name: Soehianto, Serafina
Publisher: name: The University of Edinburgh
Year: 2025
Subjects: subject: mitochondrial aldehyde dehydrogenase
subject: ALDH2
subject: variants of unknown clinical significance
subject: Deep mutational scanning
subject: variant effect predictors

description: The ALDH2 gene encodes mitochondrial aldehyde dehydrogenase, an enzyme crucial for ethanol metabolism and aldehyde detoxification. A common pathogenic variant, ALDH2*2, present in over 40% of East Asians, leads to the alcohol flush reaction and increases the risk of cancers, cardiovascular diseases, and Alzheimer’s disease. Over 600 other ALDH2 missense variants of unknown clinical significance (VUS) have been identified. Understanding the genotype-phenotype relationships of these VUS is essential for advancing treatments and diagnostics for associated diseases. Deep mutational scanning (DMS) is a promising approach to assess the functional effects of every missense variant in a gene. As a preliminary step to develop a competitive growth assay for screening ALDH2 variants, I performed growth complementation tests using Saccharomyces cerevisiae knockout strains transformed with plasmid-based human ALDH2 and yeast ALD genes. Despite multiple rounds of optimization, the attempt to rescue yeast ald∆ mutants with heterologous ALDH2 expression was unsuccessful, highlighting challenges in replicating previous findings of yeast ald∆ mutants complementation with heterologous ALDH2. To circumvent this, I employed population-based and population-free variant effect predictors (VEPs) alongside FoldX stability scores to predict fitness landscapes for ALDH2 and its homologs, yeast ALD4 and E. coli ALDB. Notably, yeast ALD4 exhibited a fitness landscape more similar to ALDH2 than ALDB. These findings lay the groundwork for putative future DMS experiments aiming at assessing the phenotypic effects of ALDH2 missense variants and determining their clinical relevance.
Résumé de l’Eurasie à vélo par l’Espéranto de 1928 à 1945 (p. 14)
Creators: name: Péraire, Lucien
name: CNRS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023

description: Préambule / aide-mémoire
title: Growth and differentiation of bone marrow-derived mesenchymal stem cells (BM-MSCs) seeded on calcium sulfate (CaSO4) based scaffolds
Creators: name: Chow, Yoke Yue
Publisher: name: The University of Edinburgh
Year: 2021
Subjects: subject: Bone Marrow-derived Mesenchymal Stem Cells
subject: Calcium Sulfate (CaSO4) based Scaffolds
subject: Tissue engineering therapies
subject: bone repair and regeneration
subject: Stimulan (CaSO4)
subject: Genex (CaSO4/ β-TCP)
subject: alkaline phosphatase

description: Tissue engineering therapies have been developed over the past few decades for bone repair and regeneration. Tissue-engineered constructs can be fabricated using a range of different materials. Calcium sulfate (CaSO4) based scaffolds have been used as a bone substitute for more than a century and are now commercially available. CaSO4 scaffolds have been reported to be of benefit for the healing of fracture nonunions. Bone marrow-derived mesenchymal stem cells (BM-MSCs) possess the ability to differentiate into osteoblasts. Studies have implanted scaffolds loaded with BM-MSCs into injured areas and discovered that it enhanced the recovery. In this study, human BM-MSCs were seeded onto two types of disk-shaped CaSO4 based scaffolds – Stimulan (CaSO4) and Genex (CaSO4/ β-TCP) to observe and compare growth, proliferation and osteogenic differentiation of BM-MSCs on the scaffolds. Two time points (7 days and 21 days) were used for each scaffold. BM-MSCs attached to plastic culture flask surface when observed using microscope. BM-MSCs differentiation assays showed that these cells were able to undergo osteogenic and adipogenic differentiation. Flow cytometry indicated BM-MSCs expressed a specific set of MSCs surface markers which were CD90, CD44, CD73 and CD105. The 4′,6-diamidino-2-phenylindole (DAPI) assay indicated that the number of cells on the scaffolds’ surface increased at day 21 compared to day 7. The DAPI imaged side of half-cut scaffolds showed similar penetration depth of BM-MSCs at day 7 and 21. The cell viability assay– 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay, demonstrated that BM-MSCs were able to remain viable on the scaffolds after cultured for three weeks. BM-MSCs seeded on both types of scaffolds secreted enzyme alkaline phosphatase (ALP) but revealed no significant difference in ALP level between the two types of scaffolds. Variation in donors’ cells behaviour was observed in this study as the patterns differed between donors. In conclusion, both Stimulan and Genex supported BM-MSCs growth, proliferation and osteogenic differentiation. More research on this cell-scaffold construct is needed to optimise its use in clinical practice.
title: Rapport de voyage, Flandre (1952) : Ligne des Antilles, 1965, voyage n°156
Creators: name: Burelle, Claude
name: Crenn, Edouard
name: Drouot, Bernard
name: Robichon, Yves
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: Compagnie Générale Transatlantique
subject: Transports maritimes - Histoire
subject: Marine marchande
subject: Journaux de bord

description: Chapitrage : Rapport général / du capitaine - Rapport du commissaire - Rapport du second - Rapport de l'officier de sécurité - Rapport de l'officier de navigation - Rapport du médecin - Rapport contentieux - Journal contrôle
description: Source: French Lines & Compagnies, 1997 004 4993-17
description: Coverage: 1965-07-01/1965-07-23
title: CrrAB-dependent capsule formation in K.pneumoniae
Creators: name: Vidalis, Kyriakos
Publisher: name: The University of Edinburgh
Year: 2021
Subjects: subject: Klebsiella pneumoniae
subject: CrrAB-dependent capsule formation
subject: β-lactam resistance
subject: colistin susceptibility
subject: Colistin Resistance
subject: Acquired Colistin Resistance
subject: Intrinsic Colistin Resistance
subject: CrrAB mutations

description: The pace at which multidrug-resistant bacteria (MDR) are increasing and spreading around the world is worrying and it is now recognised by the World Health Organization as a public health threat (Shrivastava, Shrivastava and Ramasamy, 2018). To give a scale on the pressing issue, Jim O’ Neill in his report on anti-microbial resistance (AMR) predicted a drastic increase in deaths caused by MDR bacteria, potentially reaching 50.000.000 deaths per year by 2050 (Review on Antimicrobial Resistance, 2016). Bacteria can acquire resistance through transmission of antimicrobial resistance genes (carried either on bacterial chromosome, plasmids, or transposons), to multiple antibiotics. Thus, creating MDR bacteria (Paterson, 2004). In order to raise awareness, the World Health Organization (WHO) has recently identified the ESKAPES (E. faecium, S. aureus, K.pneumoniae, A. baumannii, P.aeruginosa, Enterobacter spp. , S. maltophila) group of pathogens which pose an imminent threat to human and animal health as antibiotic options against these bacteria are limited (Antibiotic-resistant priority pathogens list, 2017). To be precise, carbapenem resistant A. baumannii and P. aeruginosa, extended spectrum β-lactamase (ESBL) or carbapenem resistant K. pneumoniae and Enterobacter spp. are listed in the critical priority list of pathogens. Vancomycin resistant E. faecium (VRE) and methicillin and vancomycin resistant S. aureus (MRSA and VRSA) are in the high priority group (Antibiotic-resistant priority pathogens list, 2017). Klebsiella pneumoniae in the clinical setting. The critical priority list consists of three pathogens which amount for most nosocomial infections. Klebsiella pneumoniae and Acinetobacter spp. interchange between the highest rate of infection (Agaba, Tumukunde, Tindimwebwa and Kwizera, 2017). The high infection rate is attributed to their ability to exhibiting multiple pathogenesis routes leading to a plethora of symptoms. These can range from pneumoniae to liver abscesses and septic shock, ultimately proving lethal if left untreated. Furthermore, their virulence can greatly increase through the acquisition of mobile elements (such as pathogenicity islands) or through chromosomal mutations leading to increased avoidance of the host immune system (Podschun and Ullmann, 1998). Overall, these capabilities make them successful in colonization of the host and in producing disease. But they do not render treatment regimens ineffective. Thus, the major threat lies when these capabilities are coupled to extensive resistance to antibiotics. One of the most studied examples is the increased mortality rate associated with MDR K.pneumoniae arising from the recent surge in AMR.
title: Identifying indicators for paediatric palliative care assessment: a scoping review
Creators: name: Cui, Amy
Publisher: name: The University of Edinburgh
Year: 2021
Subjects: subject: Paediatric Palliative Care Assessment
subject: life-limiting conditions
subject: children and young people up to age 25
subject: children and young people up to age 25 with life-limiting conditions
subject: advance care planning

description: BACKGROUND: The prevalence of life-limiting conditions among children and young people in the UK continues to rise, as does the need for paediatric palliative care. Identifying triggers for paediatric palliative care referral or initiating early discussions about advance care planning could benefit these families. AIM: I aimed to identify indicators suited to assessing children and young people up to age 25 with life-limiting conditions for palliative care assessment and advance care planning. METHODS: Guided by Arksey & O’Malley’s scoping review framework modified by Levac and et al., I searched seven databases from January 2000-January 2020. Studies that either described existing tools or reported relevant clinical research were analysed separately and then synthesised to identify indicators for a paediatric palliative care assessment. The findings were compared with referral criteria used by UK paediatric palliative care services obtained from websites or by email to identify gaps between research and clinical practice and inform recommendations. RESULTS: I included seven articles that reported studies of existing screening and assessment tools used to identify children with palliative care needs. In addition, 19 articles focused on symptoms (n=6), and end-of-life experiences of life-limiting conditions (n=13). 18 general indicators under 12 themes were identified. Condition group-specific indicators were identified for cancer, neonatal conditions, neurological disorders, and organ failure, as those represented the main condition groups. In total, seventeen hospice and four hospital-based UK paediatric palliative service referral criteria were obtained. Admission criteria for most of the children’s hospices were based on physical symptoms, medical interventions, and treatment outcomes. The hospital services used clinical judgement to assess referrals. None of the programmes used any of the tools described in the seven included articles on existing tools. CONCLUSION: Paediatric palliative care service planning and ensuring timely access for children and young people is complex due to heterogeneity in conditions, trajectories, and outcomes. My review demonstrated that indicators associated with psychosocial factors and family needs were applicable to all life-limiting conditions in paediatric palliative care assessment. Indicators associated with disease-specific symptoms, treatments and interventions could be grouped into broader categories of similar diseases that may be used to develop a multidimensional assessment tool. Prospective testing of the review findings and development of prototype tools based on clinical indicators for paediatric palliative care assessment are needed.
Pharmacophore-based virtual screening of the chromone derivatives as potential therapeutic for Alzheimer’s disease
Creators: name: Kumar, Naveen
name: Devi, Bharti
name: Jangid, Kailash
name: Kumar, Vinod
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Alzheimer’s disease is one of the most complex neurological disorders and millions of people are suffering from this disease all over the world. In the past two decades acetylcholinesterase (AChE) has been the most explored pathological hallmark. The generation of potent AChE inhibitors has grown as a rapid pathological tool for the efficacious treatment of the disease. Hence, AChE enzyme is extensively explored as a drug discovery tool for the development of potent therapeutics. We have used chromone derivatives with known biological activities for developing a Gaussian field-based 3D QSAR pharmacophore model using PHASE module of Schrodinger with statistically significant R2 and Q2 values of 0.92 and 0.9209, respectively. ChEMBL and MCULE databases were screened using the best pharmacophore hypothesis model (AAHHRR_4) with features of two hydrogen bond acceptors (A1, A2), two hydrophobic regions (H1, H2), and two aromatic regions (R1, R2). These were subjected to structure-based virtual screening using extra precision, MM/GBSA and ADME calculations for calculating the binding free energies and pharmacokinetic properties, respectively. Subsequently, two hit molecules i.e. CHEMBL1319989 and MCULE-2246633290 were identified. The leads exhibited higher docking score (−8.859 and −9.984 kcal/mol) and ΔGbinding (−57.63 and −56.45 kcal/mol) as compared to the reference (ΔGbinding= −53.79 kcal/mol). MD simulation study exhibited stable interactions with the binding free energy (ΔGMMPBSA) of −27.29 and −21.26 kcal/mol for CHEMBL1319989 and MCULE-2246633290, respectively. So, the generated pharmacophore model may be considered as a valuable tool for the development of potent AChE inhibitors for the treatment of AD.
Tetramorium noeli
Creators: name: Hita Garcia, F.
name: B. L. Fisher
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium noeli

description: Tetramorium noeli species complex
This species complex contains the species T. ambanizana, T. aherni, T. singletonae, and T. noeli. The characters that define the complex are the lack of sculpture on the forecoxae and the presence of basigastral costulae on the first gastral tergite.
The four species of this complex appear to be morphologically close to each other, and it is likely that they represent a natural group with shared common ancestry.
description: Published as part of Hita Garcia, F. & B. L. Fisher, 2012, The ant genus Tetramorium Mayr (Hymenoptera: Formicidae) in the Malagasy region - taxonomic revision of the T. kelleri and T. tortuosum species groups., pp. 1-85 in Zootaxa 3592 on page 56
Megaphyllum lictor
Creators: name: Kime, Richard Desmond
name: Enghoff, Henrik
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Julida
Julidae
Megaphyllum
Megaphyllum lictor

description: 390. Megaphyllum lictor (Attems, 1904)
Brachyiulus lictor Attems, 1904.
Chromatoiulus lictor auct.
Distribution
BG, RO, TR-TUE. East Balkan.
Habitat
Broad-leaved forests, especially Quercus. Also Fagus. Up to 1500 m.
description: Published as part of Kime, Richard Desmond & Enghoff, Henrik, 2017, Atlas of European millipedes 2: Order Julida (Class Diplopoda), pp. 1-299 in European Journal of Taxonomy 346 on page 124, DOI: 10.5852/ejt.2017.346, http://zenodo.org/record/3866525
Exacta VII Provinciarum Tabula; [um 1700]
Creators: name: (:Unav)
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2023

description: Beigefügt "Beschrijvinge der Vrye Vereenighde Nederlanden" und zwölf Stadtansichten (Amsterdam; Leeuwaerden; Uitrecht; Groningen; s'Hertogenbos; Hulst; Nimmeghen; Dordrecht; Middelburgh; Deventer; Breda; Grave)
Event-based Mosaicing Bundle Adjustment
Creators: name: Guo, Shuang
name: Gallego, Guillermo
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Robotics (cs.RO)
subject: Image and Video Processing (eess.IV)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: We tackle the problem of mosaicing bundle adjustment (i.e., simultaneous refinement of camera orientations and scene map) for a purely rotating event camera. We formulate the problem as a regularized non-linear least squares optimization. The objective function is defined using the linearized event generation model in the camera orientations and the panoramic gradient map of the scene. We show that this BA optimization has an exploitable block-diagonal sparsity structure, so that the problem can be solved efficiently. To the best of our knowledge, this is the first work to leverage such sparsity to speed up the optimization in the context of event-based cameras, without the need to convert events into image-like representations. We evaluate our method, called EMBA, on both synthetic and real-world datasets to show its effectiveness (50% photometric error decrease), yielding results of unprecedented quality. In addition, we demonstrate EMBA using high spatial resolution event cameras, yielding delicate panoramas in the wild, even without an initial map. Project page: https://github.com/tub-rip/emba
description: 14+11 pages, 11 figures, 10 tables, https://github.com/tub-rip/emba
Megaphyllum margaritatum
Creators: name: Kime, Richard Desmond
name: Enghoff, Henrik
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Julida
Julidae
Megaphyllum
Megaphyllum margaritatum

description: 392. Megaphyllum margaritatum (Fanzago, 1875)
Julus margaritatus Fanzago, 1875.
Chromatoiulus margariatus auct.
Brachyiulus aetnensis Verhoeff, 1910.
Brachyiulus garganensis Verhoeff, 1932.
Distribution
GR-GRC, IT-ITA, IT-SI.
Habitat
Pastures. Fagus forest. One record at 990 m in the Epirus and only above 1200 m in Calabria.
Remarks
Strasser (1974, 1976) described three varieties of M. margaritatum, one of which is now regarded as a separate species, M. creticum.
description: Published as part of Kime, Richard Desmond & Enghoff, Henrik, 2017, Atlas of European millipedes 2: Order Julida (Class Diplopoda), pp. 1-299 in European Journal of Taxonomy 346 on page 124, DOI: 10.5852/ejt.2017.346, http://zenodo.org/record/3866525
Cothornobata breviseta Li, Marshall & Yang, 2015, sp. nov.
Creators: name: Li, Xuankun
name: Marshall, Stephen A.
name: Yang, Ding
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Micropezidae
Cothornobata
Cothornobata breviseta

description: Cothornobata breviseta group
Including: C. breviseta sp. nov., C. fusca sp. nov., C. shuimanensis sp. nov.
Diagnosis. Two strong fronto-orbital setae. Genital fork elongate, reaching sternite 7, arm nearly twice as long as base, with only short setulae; basal tubercle well developed, not contiguous; medial tubercle vestigial. Distiphallus as long as or slightly shorter than phallapodeme. Pregonite lobed apically. Postgonite with 1 apical seta.
Discussion. This species group is found in central Vietnam and the coastal areas of southernmost China.
description: Published as part of Li, Xuankun, Marshall, Stephen A. & Yang, Ding, 2015, A review of the Oriental species of Cothornobata Czerny (Diptera, Micropezidae, Eurybatinae), pp. 201-246 in Zootaxa 4006 (2) on page 207, DOI: 10.11646/zootaxa.4006.2.1, http://zenodo.org/record/243797
Guaranozetes amazonicus Perez-Inigo & Baggio 1997
Creators: name: Oliveira, Anibal R.
name: Argolo, Poliane S.
name: De, Gilberto J.
name: Norton, Roy A.
name: Schatz, Heinrich
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Sarcoptiformes
Ceratokalummidae
Guaranozetes
Guaranozetes amazonicus

description: Guaranozetes amazonicus (Pérez-Íñigo & Baggio, 1997)
Belemacarus amazonicus Pérez-Iñigo & Baggio, 1997 Reported only from Brazil.
Brazil: State of Pará.
Reference: Pérez-Iñigo & Baggio (1997): 411.
description: Published as part of Oliveira, Anibal R., Argolo, Poliane S., De, Gilberto J., Norton, Roy A. & Schatz, Heinrich, 2017, A checklist of the oribatid mite species (Acari: Oribatida) of Brazil, pp. 1-89 in Zootaxa 4245 (1) on page 73, DOI: 10.5281/zenodo.437584
The key success factors of the sustainability of associative projects in the Moroccan context
Creators: name: AZIZ, My Mhamed
Publisher: name: Zenodo
Year: 2024
Subjects: associative entrepreneurship; perenniality; sustainability; associative projects; association.

description: Associative entrepreneurship is growing at the international and national levels. This increase is due to a growing need which is not being met by private enterprises, public enterprises and government measures. With the rise of international economic and financial crises, citizens around the world, including in Morocco, are demanding permanent work, fighting to reduce social inequalities and fighting against precariousness and marginalization.

It is in this context that the associative entrepreneurship found its reason of being and its fulfillment. But the entrepreneurial associative activities created face several problems and risks that threaten, at given moments of their working life, the continuity of their production process. Some activities have successfully resolved problems that almost led to the permanent cessation of their activities. Others, on the other hand, have succumbed to the serious risks and difficulties encountered.

Faced with this observation, our article has set itself the main objective of identifying the factors that have played a positive role in the process of the sustainability of entrepreneurial associative activities in the Moroccan associative context. The practical study of this work has yielded important results. Several sustainability factors have been identified and categorized.
Deinodryinus malaisei Olmi 1993
Creators: name: Xu, Zaifu
name: Olmi, Massimo
name: He, Junhua
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Dryinidae
Deinodryinus
Deinodryinus malaisei

description: 5. Deinodryinus malaisei Olmi, 1993
(Plate 56F)
Deinodryinus malaisei Olmi 1993d: 21.
Description of Male. Fully winged; length 3.2–4.2 mm. Head black, except mandible testaceous and clypeus brown; occasionally clypeus, anterior region of face and part of ventral side testaceous; antenna brown; mesosoma black; metasoma brown; legs yellow, except basal region of metacoxa black. Antenna filiform; antennal segments in following proportions: 12:6:23:20:17:15:13:12:11:13. Head dull, strongly and densely punctate, unsculptured among punctures; frontal line almost absent, only shortly present near clypeus; occipital carina complete; temples very long; POL = 5; OL = 2.5; OOL = 12; OPL = 10; TL = 14. Scutum and scutellum dull, strongly and densely punctate, unsculptured among punctures. Notauli almost absent, only shortly present near anterior margin scutum. Metanotum dull, rugose, swollen and pointed. Propodeum reticulate rugose, without longitudinal transverse keels. Fore wing slightly completely darkened; distal part of stigmal vein longer than proximal (18:7). Paramere (Plate 56F) with subdistal inner band. Tibial spurs 1/1/2. Female. Unknown.
of or part
Material examined. Types: holotype ♂: MYANMAR: Kambaiti, 2000 m, 11.VI.1934, R. Malaise leg. (ZIL Paratypes: same locality label as holotype, 25.V.1934, 2.VI.1934, 8.VI.1934, 9.VI.1934, 11.VI.1934, 17.VI.1934 17–27.VI.1934, 26♂ (21 in ZIL, five in AMNH). Hosts. Unknown.
).,
Distribution. Myanmar (Kambaiti).
description: Published as part of Xu, Zaifu, Olmi, Massimo & He, Junhua, 2013, Dryinidae of the Oriental region (Hymenoptera: Chrysidoidea), pp. 1-460 in Zootaxa 3614 (1) on page 208, DOI: 10.11646/zootaxa.3614.1.1, http://zenodo.org/record/5278372
Manifold nº 23 (Indochine nº 3) (p. 4)
Creators: name: Péraire, Lucien
name: CNRS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023

description: Confession d’un ingénieur T.P.
Analytical solutions for Maxwell-scalar system on radially symmetric spacetimes
Creators: name: Andrade, I.
name: Bazeia, D.
name: Marques, M. A.
name: Menezes, R.
name: Olmo, G. J.
Publisher: name: arXiv
Year: 2024
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We investigate Maxwell-scalar models on radially symmetric spacetimes in which the gauge and scalar fields are coupled via the electric permittivity. We find the conditions that allow for the presence of minimum energy configurations. In this formalism, the charge density must be written exclusively in terms of the components of the metric tensor and the scalar field is governed by first-order equations. We also find a manner to map the aforementioned equation into the corresponding one associated to kinks in $(1,1)$ spacetime dimensions, so we get analytical solutions for three specific spacetimes. We then calculate the energy density and show that the energy is finite. The stability of the solutions against contractions and dilations, following Derrick's argument, and around small fluctuations in the fields is also investigated. In this direction, we show that the solutions obeying the first-order framework are stable.
description: 15 pages, 8 figures. Version to appear in EPJC
Crematogaster levior Longino, 2003, NEW SPECIES
Creators: name: Longino, J. T.
Publisher: name: Zenodo
Year: 2003
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Crematogaster
Crematogaster levior

description: Crematogaster levior NEW SPECIES
Crematogaster limata r. parabiotica Forel (part): Forel, 1904b:683.
Crematogaster limata subsp. parabiotica var. levior Forel, 1911b:274. Worker: Brazil, Amazonas (H. W. Bates) [MHNG, ZSMC] (examined). Unavailable name.
Crematogaster parabiotica Forel (part): Wheeler, W.M. 1921a; Wheeler, W.M. and Darlington, 1930:109.
Crematogaster cf. limata parabiotica Forel (part): Davidson 1988, Seidel et al. 1990, Davidson et al. 1990.
Holotype worker
Brazil, Amazonas (H. W. Bates) [ZSMC]. There are two workers on one card. The holotype has been indicated with a black arrow drawn on the card.
Range
Amazonian portions of Brazil, Guianas, Venezuela, Colombia, Ecuador, Peru, Bolivia.
Description of worker
Pronotal dorsum almost entirely smooth and shiny, with no trace of carinulae, or with faint traces along anterolateral margins; other characters as in carinata.
Measurements
Holotype: HL 0.587, [HW, HC not visible], SL 0.586, EL 0.142, WL 0.672, SPL 0.130, PTH 0.141, PTL 0.201, PTW 0.152, PPL 0.145, PPW 0.147, OI 24, SI 100, PTHI 70, PTWI 76, PPI 101, SPI 19.
Biology
Crematogaster levior occurs in lowland wet forest habitats, where it cohabits large ant gardens with Camponotus femoratus. See carinata.
description: Published as part of Longino, J. T., 2003, The Crematogaster (Hymenoptera, Formicidae, Myrmicinae) of Costa Rica., pp. 1-150 in Zootaxa 151 on pages 132-133
title: Rapport de voyage, Mariette Pacha (1925) : Ligne d'Egypte et Syrie, 1938, voyage n°2
Creators: name: Caboufigue, Louis
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: Compagnie des Messageries Maritimes
subject: Transports maritimes - Histoire
subject: Marine marchande
subject: Journaux de bord

description: Chapitrage : Rapport du commandant - Rapport de mer
description: Source: French Lines & Compagnies, 1997 002 4190-69
description: Coverage: 1938-01-04/1938-01-18
Guaranozetes nudus Balogh & Mahunka 1981
Creators: name: Oliveira, Anibal R.
name: Argolo, Poliane S.
name: De, Gilberto J.
name: Norton, Roy A.
name: Schatz, Heinrich
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Sarcoptiformes
Ceratokalummidae
Guaranozetes
Guaranozetes nudus

description: Guaranozetes nudus Balogh & Mahunka, 1981
Neotropical region.
Brazil: State of São Paulo.
Reference: Oliveira et al. (2005): 62.
description: Published as part of Oliveira, Anibal R., Argolo, Poliane S., De, Gilberto J., Norton, Roy A. & Schatz, Heinrich, 2017, A checklist of the oribatid mite species (Acari: Oribatida) of Brazil, pp. 1-89 in Zootaxa 4245 (1) on page 73, DOI: 10.5281/zenodo.437584
LGBT RIGHTS IN BHUTAN- A CRITICAL STUDY
Creators: name: Jigdrel Wangmo
name: DR GEETA
Publisher: name: Journal of Positive School Psychology
Year: 2022
Subjects: LGBT rights
social media
Bhutanese Penal Code

description: Around the worlds, LGBT rights are a matter of discussion and some of the rights have been arranged for the community. But, the rural areas in Bhutan, hardly any discussion of LGBT issues is noted. Although, the community found speaking up for their rights with the help of media and social media. The provisions of section 213 and 214 of the Bhutanese Penal Code which criminalized “unnatural sex” or “homosexuality” omitted on 10th of December 2020, by the joint sitting of both houses of Bhutan’s parliament after prolonged intensive campaigns by activists, advocates and by the individuals belonging to the LGBT community themselves. Despite the amendments, homosexuality still considered a taboo subject in conservative religious Bhutanese society, this has made the lives of the members of LGBT community hard and unworthy of living. There is hardly any discussion of LGBT issues in the rural areas in Bhutan as they think that sexual orientations of that kind is against the order of nature. This paper for displaying a true picture about the lives and rights of the members of LGBT community prior to and after decriminalizing homosexuality and suggest suitable changes in the existing system to ensure rights to the community in Bhutan with the help of doctrinal and nondoctrinal methodology
Deinodryinus nanchangensis Xu & He 1995
Creators: name: Xu, Zaifu
name: Olmi, Massimo
name: He, Junhua
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Dryinidae
Deinodryinus
Deinodryinus nanchangensis

description: 6. Deinodryinus nanchangensis Xu & He, 1995
(Plate 57A)
Deinodryinus nanchangensis Xu & He 1995c: 2; He & Xu 2002: 103.
Description of Male. Fully winged; length 2.3–2.9 mm. Head black, except mandible testaceous; antenna brown; mesosoma black; metasoma missing in holotype; legs testaceous, except proximal half of metacoxa black. In specimen from China, Pingwu, antenna brown, except segments 7–10 testaceous, and metasoma brown. Antenna filiform, with hairs slightly shorter than breadth of segments; antennal segments in following proportions: 7.5:4.3:7.5:7:7:7:6:6:6:7.7. Head shiny, densely punctate, unsculptured among punctures; vertex without two oblique keels from posterior ocelli to occipital carina; frontal line absent; occipital carina complete; POL = 2.4; OL = 1.4; OOL = 6.2; OPL = 3.3; TL = 4. Scutum shiny, punctate and unsculptured among punctures. Notauli thin, incomplete, reaching approximately 0.5 length of scutum (not 0.3 as written in original description). Scutellum and metanotum shiny, smooth, punctate, unsculptured among punctures. In specimen from China, Pingwu, metanotum with few areolae. Propodeum dull, reticulate rugose, with transverse keel between dorsal and posterior surface; posterior surface completely reticulate rugose, with two longitudinal keels (in specimen from China, Pingwu, longitudinal keels irregular). Fore wing hyaline, without dark transverse bands; distal part of stigmal vein slightly shorter than proximal part (4.5: 7 in holotype; 9: 11 in specimen from China, Pingwu). Pterostigma more than four times as long as broad. Genitalia of holotype missing. Paramere of specimen from China, Pingwu (Plate 57A) with inner branch sculptured by papillae. Tibial spurs 1/1/2.
Female. Unknown.
Material examined. Type: holotype ♂: CHINA: Jiangxi, Nanchang City, 1978, Zhengxiang Ye leg. (ZJUC). Other material. CHINA: Sichuan, Baimazhai, Pingwu, 25.VII.2006, Hongying Zhang leg., 1♂ (ZJUC).
Hosts. Unknown.
Distribution. China (Jiangxi, Sichuan).
description: Published as part of Xu, Zaifu, Olmi, Massimo & He, Junhua, 2013, Dryinidae of the Oriental region (Hymenoptera: Chrysidoidea), pp. 1-460 in Zootaxa 3614 (1) on page 209, DOI: 10.11646/zootaxa.3614.1.1, http://zenodo.org/record/5278372
Megaphyllum metsovoni
Creators: name: Kime, Richard Desmond
name: Enghoff, Henrik
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Julida
Julidae
Megaphyllum
Megaphyllum metsovoni

description: 393. Megaphyllum metsovoni (Strasser, 1976)
Chromatoiulus metsovoni Strasser, 1976.
Distribution
GR-GRC (Epirus and Parnassos Mountains)
Habitat
Found at 1630 m in the Metsovon Pass and in Picea forest at 1115 m on Parnassos Mts.
description: Published as part of Kime, Richard Desmond & Enghoff, Henrik, 2017, Atlas of European millipedes 2: Order Julida (Class Diplopoda), pp. 1-299 in European Journal of Taxonomy 346 on page 124, DOI: 10.5852/ejt.2017.346, http://zenodo.org/record/3866525
EDGE-INFERNO: Simulating every observable star in faint dwarf galaxies and their consequences for resolved-star photometric surveys
Creators: name: Andersson, Eric P.
name: Rey, Martin P.
name: Pontzen, Andrew
name: Cadiou, Corentin
name: Agertz, Oscar
name: Read, Justin I.
name: Martin, Nicolas F.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Interpretation of data from faint dwarf galaxies is made challenging by observations limited to only the brightest stars. We present a major improvement to tackle this challenge by undertaking zoomed cosmological simulations that resolve the evolution of all individual stars more massive than $0.5\,{\rm M}_{\odot}$, thereby explicitly tracking all observable stars for the Hubble time. For the first time, we predict observable color-magnitude diagrams and the spatial distribution of $\approx 100,000$ stars within four faint ($M_{\star} \approx 10^5 \, \,{\rm M}_{\odot}$) dwarf galaxies directly from their cosmological initial conditions. In all cases, simulations predict complex light profiles with multiple components, implying that typical observational measures of structural parameters can make total V-band magnitudes appear up to 0.5 mag dimmer compared to estimates from simulations. Furthermore, when only small ($\lessapprox100$) numbers of stars are observable, shot noise from realizations of the color-magnitude diagram introduces uncertainties comparable to the population scatter in, e.g., total magnitude, half-light radius, and mean iron abundance measurements. Estimating these uncertainties with fully self-consistent mass growth, star formation and chemical enrichment histories paves the way for more robust interpretation of dwarf galaxy data.
description: Published in ApJ
Megaphyllum loebli
Creators: name: Kime, Richard Desmond
name: Enghoff, Henrik
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Julida
Julidae
Megaphyllum
Megaphyllum loebli

description: 391. Megaphyllum loebli (Strasser, 1974)
Chromatoiulus loebli Strasser, 1974.
Distribution
GR-GRC (Peloponnese).
Habitat
Gorges with forest; conifers and Platanus, in leaf litter. One site at 885 m.
Remarks
Only two known sites, a ravine at Kalavrita and a gorge at Korfes in Arkadia County.
description: Published as part of Kime, Richard Desmond & Enghoff, Henrik, 2017, Atlas of European millipedes 2: Order Julida (Class Diplopoda), pp. 1-299 in European Journal of Taxonomy 346 on page 124, DOI: 10.5852/ejt.2017.346, http://zenodo.org/record/3866525
title: Activité du port de Saint-Malo – 1761 – Jersey
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: personnes

description: Cette fiche est issue de l’enquête menée par Jean Delumeau sur l’activité du port de Saint-Malo au 17e et 18e siècle. Cette fiche correspond à l’activité de l’année 1761 avec le port "Jersey"
description: Marchandises arrivées à Saint-Malo : passagers
description: Catégories de marchandises arrivées à Saint-Malo : personnes
description: Coverage: Grand commerce
description: Bibliographic citation: LE POEZAT-GUIGNER, Annie. Les Activités du port de Saint-Malo en 1761. DES : Histoire : Rennes : 1967 (Bibliothèque François-Lebrun, MH 1050)
description: date: Date de numérisation : 2021 à 2023
description: created: Années 1950-1960
Ceratozetes (Ceratozetes) catarinensis Perez-Inigo & Perez-Inigo Jr. 1993
Creators: name: Oliveira, Anibal R.
name: Argolo, Poliane S.
name: De, Gilberto J.
name: Norton, Roy A.
name: Schatz, Heinrich
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Sarcoptiformes
Ceratozetidae
Ceratozetes
Ceratozetes catarinensis

description: Ceratozetes (Ceratozetes) catarinensis Pérez-Iñigo & Pérez-Iñigo Jr., 1993
Ceratozetes catarinensis Pérez-Iñigo & Pérez-Iñigo Jr., 1993 Reported only from Brazil.
Brazil: State of Santa Catarina.
Reference: Pérez-Iñigo & Pérez-Iñigo Jr (1993): 172.
description: Published as part of Oliveira, Anibal R., Argolo, Poliane S., De, Gilberto J., Norton, Roy A. & Schatz, Heinrich, 2017, A checklist of the oribatid mite species (Acari: Oribatida) of Brazil, pp. 1-89 in Zootaxa 4245 (1) on page 73, DOI: 10.5281/zenodo.437584
Deinodryinus philippinus Olmi 1991
Creators: name: Xu, Zaifu
name: Olmi, Massimo
name: He, Junhua
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Dryinidae
Deinodryinus
Deinodryinus philippinus

description: 7. Deinodryinus philippinus Olmi, 1991
(Plate 57B)
Deinodryinus philippinus Olmi 1991: 132.
Description of Male. Fully winged; length 2.5–2.6 mm. Head black, except mandible testaceous; antenna brown, except segments 1–2 or 1–3 testaceous; mesosoma and metasoma black; legs testaceous, except metacoxa partly darkened and club of profemur completely darkened. Antenna clavate; antennal segments in following proportions: 10:7:6:4:4:5:5:5:5:8.5. Head shiny, with vertex reticulate rugose; face not reticulate rugose, with transverse folds on sides of frontal line, with two strong keels along orbits; frontal line complete; occipital carina complete; vertex with two strong oblique keels connecting posterior ocelli to occipital carina; POL = 5; OL = 2; OOL = 8; OPL = 7; TL = 7. Scutum, scutellum and metanotum shiny, smooth, finely punctate, unsculptured among punctures. Notauli incomplete, reaching approximately 0.3 length of scutum. Scutellum and metanotum very swollen. Propodeum with a transverse keel between dorsal and posterior surface; dorsal surface very short, reticulate rugose; posterior surface reticulate rugose, without longitudinal keels. Fore wing hyaline, without dark transverse bands; distal part of stigmal vein shorter than proximal part (2:7). Paramere (Plate 57B) approximately as long as penis, with large inner branch wrapping penis. Tibial spurs 1/1/2.
Female. Unknown.
Material examined. Type: holotype ♂: PHILIPPINES: Mindanao Isalnd, Misamis Oriental Prov., 21 Km W Gingoog City, Mt. Pomalihi, 800–1000 m, 15.IX.1965, light trap, H.M. Torrevillas leg. (BPBM). Other material. INDONESIA: Sumbawa Island, Pancasila, near Gn. Tambora, 500 m, 27.IX–2.X.1993 (AMNH).
Hosts. Unknown.
Distribution. Philippines (Mindanao), Indonesia (Sumbawa).
description: Published as part of Xu, Zaifu, Olmi, Massimo & He, Junhua, 2013, Dryinidae of the Oriental region (Hymenoptera: Chrysidoidea), pp. 1-460 in Zootaxa 3614 (1) on page 209, DOI: 10.11646/zootaxa.3614.1.1, http://zenodo.org/record/5278372
The feasibility of assessing prognosis over 3 years in persons with a previous stroke/ transient ischemic attack in general practice
Creators: name: Ryan, Eimear
name: Gill, Harmeet
name: Doogue, Róisín
name: McCann, David
name: Murphy, Andrew W
name: Hayes, Peter
Publisher: name: University of Limerick
Year: 2025
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences

description: Background Stroke has devastating consequences for survivors. Hypertension is the most important modifiable risk factor, and its management largely takes place in primary care. However, most stroke-based research does not occur in this setting. Ongoing hypertension and a risk of further stroke are a major concern for both patients and their general practitioners. We aim to assess whether it is feasible to assess prognosis in persons, with a previous stroke or transient ischemic attack (TIA), in general practice, and whether a well-powered observational study is possible. Methods We performed a search of the electronic health record of individuals previously identified as having had a stroke or TIA, to assess prognosis over 3 years. Feasibility was assessed by meeting five criteria: (1) all general practices approached participated, (2) greater than 90% of patient records were accessible, (3) all study outcomes were available to review, (4) that collection data was less than 15 min per patient, and (5) a power calculation for a planned observational study could take place. Results All six general practices approached participated freely, and 193/196 patients’ files were reidentified (98.5%). Twenty-eight cardiovascular events were recorded—most commonly a repeat TIA or ischemic stroke. Data collection took on average 5.5 min per file, and a power calculation for a planned observational study was completed. Conclusion This study demonstrates that the proposed methodology for a full cohort study within general practice of patients post-stroke/TIA is both acceptable to practices and feasible. An adequately powered, “time-to-event” study is possible.
Megaphyllum mueggenburgi
Creators: name: Kime, Richard Desmond
name: Enghoff, Henrik
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Diplopoda
Julida
Julidae
Megaphyllum
Megaphyllum mueggenburgi

description: 395. Megaphyllum mueggenburgi (Verhoeff, 1901)
Brachyiulus mueggenburgi Verhoeff, 1901.
Chromatoiulus mueggenburgi auct.
Cerabrachyiulus mueggenburgi auct.
Distribution
GR-DOD (Kasos, Karpathos).
Habitat
Found between 800 and 1400 m (Lazányi et al. 2012).
description: Published as part of Kime, Richard Desmond & Enghoff, Henrik, 2017, Atlas of European millipedes 2: Order Julida (Class Diplopoda), pp. 1-299 in European Journal of Taxonomy 346 on page 125, DOI: 10.5852/ejt.2017.346, http://zenodo.org/record/3866525