cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The incidence of enlarged chondrons in normal and osteoarthritic human cartilage and their relative matrix density
Creators: name: Paul, T. A.
name: Slabaugh, M.
name: Lee, G. M.
name: Kelley, S. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: OBJECTIVE: To quantitate changes in the pericellular matrix in osteoarthritic (OA) articular cartilage. DESIGN: Chondrons were enzymatically isolated from normal and OA human cartilage. The cross-sectional area of the chondrons were measured. After immunolabeling for keratan sulfate, type VI collagen and type II collagen, the relative matrix density was determined for different size classes of chondrons with quantitative fluorescence microscopy. RESULTS: For individual chondrons, the average cross-sectional area (344+/-28 microm(2), mean+/-SE) for the normal specimens was significantly smaller than the average area (439+/-30 microm(2)) for the OA specimens. Using 496 microm(2) (mean+2 SD of the normal area) as the cut-off for enlarged chondrons, 33% of individual OA chondrons were enlarged compared to 16% for the normal. Chondrons under 300 microm(2) had a significantly higher density of keratan sulfate and type VI collagen than larger chondrons, while chondrons over 400 microm(2) had similar matrix densities. CONCLUSIONS: There is a higher incidence of enlarged chondrons in OA cartilage than in normal cartilage. The enlargement may initially be due to hydrodynamic swelling but further increases in size are due to increased matrix deposition.
(100274) Annie James
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
ИСПОЛЬЗОВАНИЕ МАССОВЫХ ОТКРЫТЫХ ОНЛАЙН-КУРСОВ В ПРОЦЕССЕ ОБУЧЕНИЯ
Creators: name: Маркова Гульфия Альмянсуровна
Publisher: name: Эпоха науки
Year: 2020
Subjects: массовые открытые онлайн-курсы
дистанционные технологии
мультимедийная презентация
дистанционное обучение.

description: В статье, написанной Марковой Г.А., рассматриваются актуальные вопросы использования онлайн-курсов в процессе обучения. Автор раскрывает историю создания массовых открытых онлайн-курсов за рубежом, цели и особенности преподавания в формате дистанционного образования, приводит статистические данные по этой проблеме. Выявлены отличительные особенности онлайн-курсов в области обучения иностранным языкам. Проанализированы преимущества и недостатки дистанционных технологий, применяемых на занятиях по иностранному языку в вузе. Раскрыты особенности дистанционного обучения с применением мультимедийных презентаций. Интегрированные занятия в сопровождении мультимедийных презентаций, online-тестов и программных продуктов позволяют студентам получать знания в более продуктивной форме.
ДИАЛЕКТИЧЕСКОЕ МЫШЛЕНИЕ КАК ОСНОВА СОВРЕМЕННОГО ПРОФЕССИОНАЛЬНОГО ОБРАЗОВАНИЯ
Creators: name: Поляруш Альбина Анатольевна
Publisher: name: Эпоха науки
Year: 2020
Subjects: образование
знание
интеллект
способ мышления
метод
логика
противоречие.

description: Интеллектуальный труд, как и физический, обладает всеми признаками труда вообще. Одним из таких всеобщих признаков выступает опосредствованность. В случае физического труда эту опосредствованность обеспечивают орудия труда. В случае интеллектуального труда – это метод мышления. Другими словами, в учебном процессе необходимо лишь вывести метод, общий подход к познанию единого и многообразного мира и на его основе преобразования природы. Таким всеобщим методом познания обладает диалектика. Педагогика, формирующая будущего профессионала, должна произвести трансформацию самой образовательной парадигмы, чтобы успешно отвечать на вызовы современной эпохи.
REVIEW AND ANALYSIS OF LOT IDENTIFIER INFORMATION DATA IN THE VACCINE ADVERSE EVENT REPORTING SYSTEM (VAERS)
Creators: name: Badoo, Judith Akouyo
Publisher: name: Maryland Shared Open Access Repository
Year: 2012

description: Vaccine lot identifier information reporting to the Vaccine Adverse Event Reporting System (VAERS) database is important for post-licensure product safety surveillance. VAERS-initial-report data were used to evaluate the extent of missing lot identifier information. Publicly accessible VAERS data for pneumococcal conjugate vaccine (PCV) and pneumococcal polysaccharide vaccine (PPV) were analyzed for the variables potentially associated with completeness of lot identifier information. Analysis of the data showed lot identifier information was more likely to be included in VAERS reports for PCV, serious adverse events, by publicly funded source of administrators, and by those submitted by sources other than manufacturers. PPV VAERS-initial-reports data suggested that 56.4% of this vaccine was administered to the wrong age group of children (under 2 years old). While VAERS data has many limitations it serves as a valuable tool for vaccine safety surveillance, it is important for reporters to include complete and accurate lot identification information.
Assuming Ionization Equilibrium and the Impact on the Lyman-$\mathrmα$ Forest Power Spectrum during the End of Reionization at $8 \geq z \geq 5$
Creators: name: Kušmić, Samir
name: Finlator, Kristian
name: Keating, Laura
name: Huscher, Ezra
Publisher: name: arXiv
Year: 2022
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We explore how the assumption of ionization equilibrium modulates the modeled intergalactic medium (IGM) at the end of the hydrogen Epoch of Reionization using the cosmological radiation hydrodynamic \textsc{Technicolor Dawn} simulation. In neutral and partially-ionized regions where the metagalactic ultraviolet background (UVB) is weak, the ionization timescale $t_\mathrm{ion}\equiv Γ^{-1}$ exceeds the Hubble time. Assuming photoionization equilibrium in such regions artificially boosts the ionization rate, accelerating reionization. By contrast, the recombination time $t_\mathrm{rec} < t_\mathrm{ion}$ in photoionized regions, with the result that assuming photoionization equilibrium artificially increases the neutral hydrogen fraction. Using snapshots between $8 \geq z \geq 5$, we compare the predicted Lyman-$α$ forest flux power spectrum with and without the assumption of ionization equilibrium. Small scales ($k > 0.1$ rad s km$^{-1}$) exhibit reduced power from $7 \leq z \leq 5.5$ in the ionization equilibrium case while larger scales are unaffected. This occurs for the same reasons: ionization equilibrium artificially suppresses the neutral fraction in self-shielded gas and boosts ionizations in voids, suppressing small-scale fluctuations in the ionization field. When the volume-averaged neutral fraction drops below $10^{-4}$, the signature of non-equilibrium ionizations on the Lyman-$α$ forest (LAF) disappears. Comparing with recent observations indicates that these non-equilibrium effects are not yet observable in the LAF flux power spectrum.
description: This has been submitted and accepted to ApJ as of April 11, 2022
GENERATION OF A MUTANT FLY TO EVALUATE THE IN VIVO ROLE OF PA-PLA1 IN DROSOPHILA
Creators: name: Balagatte, Sanchitha G.
Publisher: name: Maryland Shared Open Access Repository
Year: 2006

description: Our long term goal is to understand how proteins mediate, in vivo, the complex interrelationship between the lipid metabolism and membrane bending , in relavence to fission and fusion of vesicles. Phospholipases constitute a diverse group of enzymes involved in metabolism of the phosphoglycerolipids and generate second messengers for a number of different signaling pathways and also has a role in intracelluluar membrane trafficking and vesicular transport (6). Our main focus of the study is to evaluate the in vivo role of phosphatidic specific phospholipase Al (PA-PLA1) enzyme in Drosophila.The specific objective of the study is to generate tools such as Drosophila PA-PLA1 specific antibody and a mutant to study the in vivo role of PA-PLA1.
The emergence of universal relations in the AdS black holes thermodynamics
Creators: name: Sadeghi, J.
name: Pourhassan, B.
name: Gashti, S. Noori
name: Upadhyay, S.
name: Mezerji, E. Naghd
Publisher: name: arXiv
Year: 2020
Subjects: subject: General Physics (physics.gen-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Our primary goal in this paper is to confirm new universal relations in black hole thermodynamics. We investigate the universal relations by selecting different black holes. First, we obtain the black holes' thermodynamic relations assuming a new minor correction is added to the AdS part of the action. Then we confirm the universal relations by performing a series of direct calculations. It is noteworthy that according to each of the properties related to black holes, a new universal relation can be obtained according to this method. We confirm two different types of these universal relations for various block holes. Furthermore, we also consider black holes in AdS space surrounded by perfect fluid. We use the small correction to the action and obtain the modified thermodynamic quantities. We achieve two new universal relations which correspond to the parameters of perfect fluid and magnetic charge of the Bardeen AdS Black Hole. Finally, the new universal relation leads us to understand the charge-to-mass ratio, i.e., WGC-like behavior. We also find that the weak gravity conjecture condition is satisfied for the black hole surrounded by perfect fluid.
description: 28 pages, 4 figures, modified title
ИМЕНА ПРИЛАГАТЕЛЬНЫЕ СО ЗНАЧЕНИЕМ ОЦЕНКИ В РАССКАЗЕ В.М. ГАРШИНА «КРАСНЫЙ ЦВЕТОК»
Creators: name: Садченко Валентина Тарасовна
name: Мезенцева Василина Константиновна
Publisher: name: Эпоха науки
Year: 2020
Subjects: категория оценки
имена прилагательные
художественный текст.

description: Статья посвящена описанию категории оценки в русском языке. Обращается внимание на средства выражения данной категории, типы языковых знаков с семантикой оценки и типы оценочных значений. Рассмотрена лексико-семантическая группа имен прилагательных с оценочным значением в рассказе В.М. Гаршина «Красный цветок»; выявлены и классифицированы имена прилагательные, обладающие оценочной семой. Исследование отдельного семантического пласта оценочной лексики необходимо для определения образного потенциала данных слов и его реализации как в обычной языковой ситуации, так и в художественной литературе, в лингвистике текста
ЧТО РАСКРЫВАЮТ ПОЛЬЗОВАТЕЛИ В ПРОФИЛЕ «ВКОНТАКТЕ»: РЕЗУЛЬТАТЫ КОНТЕНТ-АНАЛИЗА
Creators: name: Сапон Ирина Валерьевна
name: Дмитрий Евгеньевич Леденев
Publisher: name: Эпоха науки
Year: 2020
Subjects: самораскрытие
социальные сети
профиль
личные данные
приватность
«ВКонтакте».

description: Социальные сети значительно упростили процесс публичного раскрытия данных. Это привело к тому, что пользователи стали раскрывать в них достаточно большое количество личной информации. Между тем персональные данные стали ценным товаром в современном цифровом мире. Они могут собираться, накапливаться и использоваться компаниями и злоумышленниками в коммерческих и преступных целях. Цель статьи – определить, какую личную информацию раскрывают пользователи в профиле самой популярной российской социальной сети. В данной работе приводятся результаты контент-анализа 15307 случайно отобранных личных страниц «ВКонтакте». Показано, что у пользователей есть определенные предпочтения, связанные с раскрытием информации в профиле. Наиболее часто они публикуют такую информацию, как аватар (87,5%), город (65,29%) и возраст (48,06%). Достаточно редко указывается номер телефона (4,17%). Наиболее приватными данными в профиле являются политические предпочтения (4,15%), религиозные взгляды (3,31%), любимые цитаты (2,61%), книги (2,48%) и игры (2,19%). Данная работа вносит вклад в понимание особенностей поведения российских пользователей. Полученные результаты могут быть использованы при межкультурном сравнении самораскрытия и приватности пользователей из разных стран.
Aharonov-Bohm oscillations in phosphorene quantum rings: mass anisotropy compensation by confinement potential
Creators: name: Thakur, Tanmay
name: Szafran, Bartlomiej
Publisher: name: arXiv
Year: 2022
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We consider the Aharonov-Bohm (AB) effect on a confined electron ground state in a quantum ring defined electrostatically within the phosphorene monolayer. The strong anisotropy of effective masses in phosphorene quenches ground-state oscillations for a circular ring because of interrupted persistent current circulation around the ring. An elliptic deformation of the confinement potential can compensate for the anisotropy of the effective masses and produce ground-state parity transformations with the AB periodicity. Moreover, a specific ratio of the semiaxes is determined for which the spectrum becomes identical to that of a circular quantum ring and an isotropic effective mass. We identify a generalized angular momentum operator which commutes with the continuum Hamiltonian for the chosen ratio of the semi-axes that closes the avoided crossings of energy levels for states of the same parity and spin. Ground-state oscillations for the two-electron ground state are also discussed.
description: PRB in print
The targum (1925:Apr. 21 - 1925:Apr. 28)
Creators: name: No Name Supplied
Publisher: name: Targum Association
Year: 1925

description: Some University historians indicate that the Targum was first published as an annual in 1867, but of this we have no extant evidence. In January 1869, the Targum as we now know it, made its appearance as a monthly paper that concerned itself with student “literary contributions” and college news as well as serving as a vehicle for bringing news to alumni and the general public. The newspaper, which originally was for sale, varied in frequency over the years as did its title (The Targum, Rutgers Targum, Rutgers Daily Targum, and Daily Targum). The newspaper has continuously been published since 1869 with the exception of 19 months during the second world war, between February 1944 and October 1945. The Targum was published by the students of Rutgers College, and later Rutgers University—New Brunswick represented through the years as the Targum Association, Rutgers Targum Association, and Rutgers College Targum. As a student organization, the Targum operated under the oversight of the dean of students and student government but in October 1980, the Targum became an independent college paper.
Gravity at Finite Temperature, Equivalence Principle,and Local Lorentz Invariance
Creators: name: Gasperini, M.
Publisher: name: arXiv
Year: 2021
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this Chapter we illustrate the close connection between the violation of the weak equivalence principle typical of gravitational interactions at finite temperature, and similar violations induced by a breaking of the local Lorentz symmetry. We also discuss the physical implications of the effective repulsive forces possibly arising in such a generalized gravitational context, by considering, for an illustrative purpose, a quasi-Riemannian model of gravity with rotational symmetry as the local gauge group in tangent space.
description: 21 pages, 3 figures. To appear in the book "Breakdown of the Einstein's Equivalence Principle", ed. by A. G. Lebed (World Scientific, 2021). A few typos corrected, two references added
УЧЕНИЕ ПЛАТОНА О ГОСУДАРСТВЕ И ОБЩЕСТВЕ В НЕМ
Creators: name: Сорокун Павел Владимирович
name: Мударисова Диана Евгеньевна
Publisher: name: Эпоха науки
Year: 2020
Subjects: государство
роль
мыслитель
философ
размышления
общество
граждане
сословия
типажи.

description: В статье проанализирована концепция о роли государства в жизни общества, по мнению известного философа Платона. Представлены определения государство, идеальное государство с точки зрения философа. Рассмотрено социальное неравенство в государстве, в основе которого находится главный признак -добродетель, где правителям уготована мудрость, защитникам – храбрость, а низшей касте – умеренность. Раскрывается тема единства, упоминается, что философ имеет негативное отношение к существованию частной собственности.
(100275) William James
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
ТИПОЛОГИЧЕСКИЕ ХАРАКТЕРИСТИКИ ОНЛАЙН-ВЕРСИЙ ДАЛЬНЕВОСТОЧНЫХ ПЕЧАТНЫХ ИЗДАНИЙ
Creators: name: Троценко Лариса Анатольевна
Publisher: name: Эпоха науки
Year: 2020
Subjects: СМИ
онлайн-версия
региональные СМИ
«Хабаровские вести»
«Тихоокеанская звезда».

description: Целью исследования стало выявление особенностей развития онлайн-версий региональных печатных средств массовой информации. Для достижения цели были поставлены следующие задачи: рассмотреть текущее состояние печатных СМИ в России и влияние цифровых технологий на их развитие; раскрыть своеобразие онлайн-версий печатных изданий (на примере региональных печатных СМИ «Хабаровские вести» и «Тихоокеанская звезда»), которым в современных условиях приходится искать новые формы существования, сохранения целевой аудитории, привлечения внимания новой, активно пользующейся Интернетом.
FDA PROPOSED RULE: SAFETY REPORTING REQUIREMENTS FOR HUMAN DRUG AND BIOLOGICAL PRODUCTS, AN IMPLEMENTATION PLAN FOR POSTMARKETING SAFETY REPORTING AT MEDIMMUNE.
Creators: name: Baracz, Michelle L.
Publisher: name: Maryland Shared Open Access Repository
Year: 2008

description: In March 2003, the United States Food and Drug Administration (FDA) issued a proposed rule titled, "Safety Reporting Requirements for Human Drug and Biological Products." This rule, upon codification, will have a significant impact on safety reporting processes in the pharmaceutical and biotechnology industries. The proposed changes will require Pharmacovigilance departments in industry to revise procedures relating to FDA safety reporting. An implementation plan is therefore an essential tool to ease the transition from complying with current regulations to complying with the regulations outlined in the proposed rule. The proposed rule encompasses changes to almost all aspects of safety reporting. This implementation plan for the Pharmacovigilance department at MedImmune will focus on three areas; terminology and definitions, followup reports, and medication errors. This plan will play a key role in ensuring that MedImmune is moving towards compliance with the proposed rule and will make the transition less burdensome.
The targum (1925:May 5 - 1925:May 19)
Creators: name: No Name Supplied
Publisher: name: Targum Association
Year: 1925

description: Some University historians indicate that the Targum was first published as an annual in 1867, but of this we have no extant evidence. In January 1869, the Targum as we now know it, made its appearance as a monthly paper that concerned itself with student “literary contributions” and college news as well as serving as a vehicle for bringing news to alumni and the general public. The newspaper, which originally was for sale, varied in frequency over the years as did its title (The Targum, Rutgers Targum, Rutgers Daily Targum, and Daily Targum). The newspaper has continuously been published since 1869 with the exception of 19 months during the second world war, between February 1944 and October 1945. The Targum was published by the students of Rutgers College, and later Rutgers University—New Brunswick represented through the years as the Targum Association, Rutgers Targum Association, and Rutgers College Targum. As a student organization, the Targum operated under the oversight of the dean of students and student government but in October 1980, the Targum became an independent college paper.
(100271) Ethel James
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
SN 2009ip: Constraining the latest explosion properties by its late-phase light curve
Creators: name: Moriya, Takashi J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We constrain the explosion and circumstellar properties at the 2012b event of SN 2009ip based on its late-phase bolometric light curve recently reported. The explosion energy and ejected mass at the 2012b event are estimated as 0.01 Msun and 2e49 erg, respectively. The circumstellar medium is assumed to have two components: an inner shell and an outer wind. The inner shell which is likely created at the 2012a event has 0.2 Msun. The outer wind is created by the wind mass loss before the 2012a mass ejection, and the progenitor is estimated to have had the mass-loss rate about 0.1 Msun/yr with the wind velocity 550 km/s before the 2012a event. The estimated explosion energy and ejected mass indicate that the 2012b event is not caused by a regular supernova.
description: 5 pages, 2 figures, 1 table, accepted by The Astrophysical Journal Letters
ATP induces Ca2+signaling in human chondrons cultured in three-dimensional agarose films
Creators: name: Banes, A.J.
name: Kelley, S.S.
name: Elfervig, M.K.
name: Sood, A.
name: Graff, R.D.
name: Lee, G.M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: OBJECTIVE: In vivo, chondrocytes are surrounded by an extracellular matrix, preventing direct cell-to-cell contact. Consequently, intercellular communication through gap junctions is unlikely. However, signaling at a distance is possible through extracellular messengers such as nitric oxide (NO) and nucleotides and nucleosides, adenosine triphosphate (ATP), uridine triphosphate (UTP), or adenosine diphosphate (ADP). We hypothesized that chondrons, chondrocytes surrounded by their native pericellular matrix, increase their intracellular calcium concentration ([Ca(2+)]ic) in response to ATP and other signaling molecules and that the source of Ca(2+) is from intracellular stores. The objectives of this study were to determine if chondrons in a 3-D gel respond to ATP by increasing [Ca(2+)]ic through a purinoceptor mechanism and to test whether chondrons in whole tissue samples would respond to ATP in a similar fashion. DESIGN: Human chondrons, cultured in a three-dimensional agarose gel or in whole cartilage loaded with Fura-2AM, a calcium sensitive dye, were stimulated with 1, 5 and 10 microM ATP. A ratio-imaging fluorescence technique was used to quantitate the [Ca(2+)]ic. RESULTS: ATP-stimulated chondrons increased their [Ca(2+)]ic from a basal level of 60 nM to over 1000 nM. Chondrons incubated in calcium-free medium also increased their [Ca(2+)]ic in response to ATP, indicating the source of Ca(2+) was not extracellular. ATP-induced calcium signaling was inhibited in chondrons pre-treated with suramin, a generic purinoceptor blocker. In addition, UTP and adenosine 5'-O-(3-thiotriphosphate) (ATPgammas) induced a calcium response, but 2-methylthio-ATP (2-MeSATP), ADP, and adenosine did not induce a significant increase in [Ca(2+)]ic, substantiating that the P2Y2 purinoceptor was dominant. Chondrons in whole cartilage increased [Ca(2+)]ic in response to ATP. CONCLUSIONS: We conclude that chondrons in 3-D culture respond to ATP by increasing [Ca(2+)]ic via P2Y2 receptor activation. Thus, ATP can pass through the agarose gel and the pericellular matrix, bind purinoceptors and increase intracellular Ca(2+) in a signaling response.
ВНЕДРЕНИЕ МОДЕЛЕЙ МЕЖПРЕДМЕТНОГО ВЗАИМОДЕЙСТВИЯ НА ЗАНЯТИЯХ ПО АНГЛИЙСКОМУ ЯЗЫКУ
Creators: name: Ульяновская Ирина Станиславовна
Publisher: name: Эпоха науки
Year: 2020
Subjects: Междисциплинарные связи
межпредметное взаимодействие
ролевая игра
профессиональная деятельность
единство образовательной программы
развитие профессионально-ориентированной языковой компетенции

description: В статье рассматривается роль междисциплинарных связей при обучении иностранному языку. Автор определяет проблемы внедрения межпредметных связей и их причины, а также представляет наиболее эффективные формы и методы обучения на практических занятиях по английскому языку с целью совершенствования моделей межпредметного взаимодействия и внедрения принципов междисциплинарного обучения. Автор приводит примеры практического внедрения моделей междисциплинарных отношений на примерах использования новых форм, средств и методов интерактивной деятельности с учетом перечня и очередности предметов, изучаемых на русском языке. Статья может быть полезна преподавателям при разработке учебно-методических материалов.
Serum cartilage oligomeric matrix protein and clinical signs and symptoms of potential pre-radiographic hip and knee pathology
Creators: name: Vilim, V.
name: Hochberg, M.C.
name: Clark, A.
name: Helmick, C.G.
name: Kraus, V.B.
name: Luta, G.
name: Dragomir, A.D.
name: Renner, J.B.
name: Jordan, J.M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: OBJECTIVE: To examine the cross-sectional relationship between serum cartilage oligomeric matrix protein (COMP) and hip and knee clinical signs and symptoms in a sample of adults without radiographic hip or knee osteoarthritis (OA). DESIGN: A total of 145 persons with available sera and no evidence of radiographic hip or knee OA (Kellgren-Lawrence grade 0) were randomly selected from the Caucasian participants of the Johnston County Osteoarthritis Project. COMP was quantified by a competitive ELISA assay with a monoclonal antibody 17-C10. Hip and knee clinical signs and symptoms were assessed by physical examination and interview, and their associations with Ln COMP analysed with general linear models. RESULTS: After adjustment for age, gender, body mass index (BMI), and other symptomatic joints, mean Ln COMP was statistically significantly higher among persons with hip-related clinical signs (P=0.018), among those with hip-related symptoms (P=0.046), and among individuals meeting American College of Rheumatology clinical criteria for hip OA (P=0.021). There were no statistically significant associations between any of the knee-related clinical signs and symptoms and Ln COMP. CONCLUSION: Serum COMP may be useful as a biomarker of pre-radiographic hip joint pathology; its utility as a biomarker of pre-radiographic knee joint pathology is unclear.
Nature of magnetotransport in metal/insulating-ferromagnet heterostructures: Spin Hall magnetoresistance or magnetic proximity effect
Creators: name: Zhou, Xiang
name: Ma, Li
name: Shi, Zhong
name: Fan, Wei-Jia
name: Zheng, Jian-Guo
name: Evans, R. F. L.
name: Zhou, Shi-Ming
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study the anomalous Hall-like effect (AHLE) and the effective anisotropic magnetoresistance (EAMR) in antiferromagnetic γ -IrMn3/Y3Fe5O12(YIG) and Pt/YIG heterostructures. For γ -IrMn3/YIG, the EAMR and the AHLE resistivity change sign with temperature due to the competition between the spin Hall magnetoresistance (SMR) and the magnetic proximity effect (MPE) induced by the interfacial antiferromagnetic uncompensated magnetic moment. In contrast, for Pt/YIG the AHLE resistivity changes sign with temperature whereas no sign change is observed in the EAMR. This is because the MPE and the SMR play a dominant role in the AHLE and the EAMR, respectively. As new types of galvanomagnetic property, the AHLE and the EAMR have proved vital in disentangling the MPE and the SMR in metal/insulating-ferromagnet heterostructures.
Development of a 120-mm Aperture Nb3Sn Dipole Coil with Stress Management
Creators: name: Novitski, I.
name: Zlobin, A. V.
name: Coghill, J.
name: Barzi, E.
name: Turrioni, D.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: This paper describes a 120-mm aperture 2-layer dipole coil with stress management (SM) developed at Fermilab based on cos-theta coil geometry. A model of the coil support structure made of plastic was printed using additive manufacturing technology and used for practice coil winding. The real coil support structure was printed using the 316 stainless steel. The results of the SM structure size control and the key coil fabrication steps are reported in the paper. The design of coil SM structure and the coil FEA in the dipole mirror test configurations are presented and discussed.
Identification of an urinary metabolite profile associated with osteoarthritis
Creators: name: DeGroot, J.
name: van der Greef, J.
name: Dragomir, A.D.
name: Kraus, V.B.
name: Jordan, J.M.
name: van Nesselrooij, J.H.J.
name: Luta, G.
name: Renner, J.B.
name: Lamers, R.J.A.N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: OBJECTIVE: Osteoarthritis (OA) is one of the most common diseases among the elderly. The main characteristic is the progressive destruction of articular cartilage. We lack quantitative and sensitive biomarkers for OA to detect changes in the joints in an early stage of the disease. In this study, we investigated whether a urinary metabolite profile could be found that could serve as a diagnostic biomarker for OA in humans. We also compared the profile we obtained previously in the guinea pig spontaneous OA model. METHODS: Urine samples of 92 participants (47 non-OA controls and 45 individuals with radiographic OA of the knees or hips) were selected from the Johnston County Osteoarthritis Project (North Carolina, USA). Participants ranged in age from 60 to 84 years. Samples were measured by 1H nuclear magnetic resonance spectroscopy (NMR) with subsequent principal component discriminant analysis and partial least squares regression analysis. RESULTS: Differences were observed between urine NMR spectra of OA cases and controls (P<0.001 for both male and female subjects). A metabolite profile could be determined which was strongly associated with OA. This profile largely resembled the profile previously identified for guinea pigs with OA (approximately 40 out of the approximately 125 signals of the human profile were present in the guinea pig profile as well). A correlation was found between the metabolite profile and radiographic OA severity (R2 = 0.82 (male); R2 = 0.93 (female)). CONCLUSION: This study showed that a urine metabolite profile may serve as a novel discriminating biomarker of OA.
ALMA constraints on assembly of Core Accretion planets
Creators: name: Nayakshin, Sergei
name: Elbakyan, Vardan
name: Rosotti, Giovanni
Publisher: name: arXiv
Year: 2022
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Resolved dust continuum and CO line ALMA imaging, and in some cases detection of H$α$ emission, hint that young massive planets are abundant at wide separations in protoplanetary discs. Here, we show how these observations can probe the runaway phase of planetary growth in the Core Accretion theory. Planets in this phase have the right range of masses to account for the predominantly moderate contrast gaps and rings seen in ALMA observations. However, we find that these planets gain mass and migrate inward very rapidly. As a result, the phase when they could produce gaps with properties similar to those observed is very short, i.e., $t_{\rm gap} \lesssim 0.1$~Myr, independently of the disc viscosity parameter. This would require many tens to hundreds of gas giant planets to be born per ALMA system, violating the available mass budget of solids in realistic discs. This also predicts preponderance of discs with very wide gaps or complete inner disc holes, which is not observed. We show that suppression of both planet accretion and migration by a factor of at least ten is a possible solution to these serious problems. Future population synthesis models of planet formation should aim to address both exoplanetary data of older discless planetary systems and ALMA discs with embedded planets in one framework.
description: 17 pages, 10 figures, Accepted by MNRAS
(100272) Florence James
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
CELL-MEDIATED CORRELATES OF PROTECTIVE IMMUNITY IN Q FEVER: LYMPHOCYTE TRANSFORMATION AND CYTOKINE RELEASE BY SPLEEN CELLS FROM MICE IMMUNIZED WITH PHASE I OR PHASE II COXIELLA BURNETII WHOLE-CELL VACCINES
Creators: name: Battersby, Luann
Publisher: name: Maryland Shared Open Access Repository
Year: 1995

description: Protective immunity against Coxiella burnetii, the causative agent of Q fever, depends primarily on cell-mediated immunity. Mice immunized with inactivated whole-cell vaccines (WCV) made from naturally occurring virulent phase I form of the organism were protected from lethal infection with 1000- fold lower vaccine doses than mice immunized with WCV made from the egg-passaged avirulent phase II form. To test the hypothesis of cytokine production correlation with protection from challenge, cytokines were measured. Spleen cell culture taken from mice immunized with various doses of WCV-Phase I (WCV-I) or WCV-Phase II (WCV-II) and stimulated with C. burnetii antigen in vitro was measured. The concentrations of interleukin 2 (IL-2), interleukin 6 (IL-6), tumor necrosis factor-a (TNF-a) and gamma interferon (IFN-y) were determined by ELISA from cell culture supernatants. For all four cytokines, spleen cell cytokine production was greater for mice immunized with WCV-I. Spleen cell supernatants from mice immunized with 100 Ag of WCV-I contained 2.1-, 5.2- and 5.3- fold greater concentrations of IFN-y, IL-6 and TNF-a, respectively, than spleen cell supernatants from mice immunized with 100 Ag of WCV-II. Supernatant production of these three cytokines from spleens of normal unimmunized mice ranged between 5 to 10 times lower than those from mice immunized with WCV-I. There was little difference in IL-2 production between mice immunized with 100 Ag WCV-I or WCV-II, but spleen cell supernatants from mice immunized with lower doses of WCV-I contained 2.2- to 3.1-fold greater concentrations of IL-2 than spleen cell supernatants from mice immunized with comparable low doses of WCV-II. These results are consistent with the hypothesis that the protective immunity induced by WCV-I may be correlated with greater cytokine production by immune T cells.
The targum (1925:June 13)
Creators: name: No Name Supplied
Publisher: name: Targum Association
Year: 1925

description: Some University historians indicate that the Targum was first published as an annual in 1867, but of this we have no extant evidence. In January 1869, the Targum as we now know it, made its appearance as a monthly paper that concerned itself with student “literary contributions” and college news as well as serving as a vehicle for bringing news to alumni and the general public. The newspaper, which originally was for sale, varied in frequency over the years as did its title (The Targum, Rutgers Targum, Rutgers Daily Targum, and Daily Targum). The newspaper has continuously been published since 1869 with the exception of 19 months during the second world war, between February 1944 and October 1945. The Targum was published by the students of Rutgers College, and later Rutgers University—New Brunswick represented through the years as the Targum Association, Rutgers Targum Association, and Rutgers College Targum. As a student organization, the Targum operated under the oversight of the dean of students and student government but in October 1980, the Targum became an independent college paper.
СИСТЕМА КОММУНИКАЦИЙ МЕЖДУ ОРГАНАМИ МЕСТНОГО САМОУПРАВЛЕНИЯ И НАСЕЛЕНИЕМ: ПРОБЛЕМЫ И ПУТИ РЕШЕНИЯ
Creators: name: Юркова Ольга Николаевна
name: Быхтин Олег Викторович
Publisher: name: Эпоха науки
Year: 2020
Subjects: местное самоуправление
гражданское общество
коммуникации
коммуникативные технологии
муниципальное управление
гражданская инициатива

description: Основная цель статьи заключается в рассмотрении системы коммуникаций между органами местного самоуправления и населения с помощью анализа эмпирических данных, выявлении проблем взаимодействия муниципальной власти и населения и поиск возможных путей решения. В методологическом отношении статья опирается на концепцию рациональности М. Вебера, различавшего содержательную и формальную рациональность как различные способы самоорганизации жизни и управленческих практик в индустриальном социуме. При написании статьи использовались методы анализа и синтеза, метод систематизации материала, применялись принципы объективности и научности. Представлены основные данные глубинного интервью, проведенного среди населения Волоконовского района Белгородской области (n = 30). Область исследования – система муниципального управления в современной России. Возможность использования статья представляет научный интерес для специалистов в области социологии управления, муниципального управления. Анализ коммуникативного взаимодействия населения и органов местного самоуправления позволит предложить механизмы создания благоприятного коммуникационного климата в муниципалитетах.
Photometric identification of the periods of the first candidate extragalactic magnetic massive stars
Creators: name: Naze, Yael
name: Walborn, Nolan R.
name: Morrell, Nidia
name: Wade, Gregg A.
name: Szymanski, Michal K.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Galactic stars belonging to the Of?p category are all strongly magnetic objects exhibiting rotationally modulated spectral and photometric changes on timescales of weeks to years. Five candidate Of?p stars in the Magellanic Clouds have been discovered, notably in the context of ongoing surveys of their massive star populations. Here we describe an investigation of their photometric behaviour, revealing significant variability in all studied objects on timescales of one week to more than four years, including clearly periodic variations for three of them. Their spectral characteristics along with these photometric changes provide further support for the hypothesis that these are strongly magnetized O stars, analogous to the Of?p stars in the Galaxy.
description: 9pages, accepted by A&A
A NOVEL METHODOLOGY FOR DEFINING THE SEQUENCE SPECIFICITIES OF DNA-BINDING PROTEINS: ANALYSIS OF GCN4 AND NEW GENE PRODUCT SBF
Creators: name: Beal, Gregory J.
Publisher: name: Maryland Shared Open Access Repository
Year: 1992

description: Transcriptional regulation of genes is exerted in part by transactivating DNA-binding proteins which interact with DNA at cis-elements to positively or negatively affect gene expression. A novel methodology was developed that identifies the nucleotide sequence specificity of DNA-binding proteins. This technique is based upon the phenomenon whereby a DNA-binding protein can bind a specific nucleotide sequence present among oligonucleotides containing random combinations of base sequences. These specific sequences are then be amplified by polymerase chain reaction (PCR) for subsequent re-selecting, cloning, sequencing and analysis. To evaluate the feasibility of this methodology, the previously characterized yeast transactivating protein, GCN4, was used as a model system. The nucleotide consensus sequence of binding was determined to be TGACTCA in agreement with previously reported data. A common variation in the consensus, which was also bound with high affinity, TGACTAN involved specificity to an A in position +2 and a loss of specificity in position +3. Moreover, this methodology allowed the identification of additional DNA sequences which were recognized by GCN4 with lower affinity; these binding sites deviated from the consensus by one or sometimes two positions, 3' to the central C residue. This data suggests that although the recognition sequence(s) were palindromic, binding to both sides was not equivalent. In addition, the consensus binding sequence of a transactivating protein SBF (S-element binding factor) was determined. A SBF cDNA clone was identified from an expression library by its binding to an oligonucleotide sequence present in the ETS-2 promoter, and was further characterized as encoding a helix-loop-helix leucine-zipper DNA binding protein. The optimal DNA-binding sequence was determined to be CACGTG. Like GCN4, the SBF protein dimer binds both sides of the palindrome with different affinities, asymmetrically allowing variations in the +1 or +2 position. Also, SBF was shown to specifically bind sequences which had mutations in the palindromic NCANNTGN motif. This population of mutant sequences were represented by the consensus PuTCAPyPuAGG.
Classification of osteoarthritis biomarkers: a proposed approach
Creators: name: Hunter, D.J.
name: Felson, D.
name: Heinegård, D.
name: Kraus, V.B.
name: Lane, N.E.
name: Saxne, T.
name: Abramson, S.B.
name: Corr, M.
name: Attur, M.
name: Tyree, B.
name: Jordan, J.M.
name: Bauer, D.C.
name: Kepler, T.B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: OBJECTIVE: Osteoarthritis (OA) biomarkers are needed by researchers and clinicians to assist in disease diagnosis and assessment of disease severity, risk of onset, and progression. As effective agents for OA are developed and tested in clinical studies, biomarkers that reliably mirror or predict the progression or amelioration of OA will also be needed. METHODS: The NIH-funded OA Biomarkers Network is a multidisciplinary group interested in the development and validation of OA biomarkers. This review summarizes our efforts to characterize and classify OA biomarkers. RESULTS: We propose the "BIPED" biomarker classification (which stands for Burden of Disease, Investigative, Prognostic, Efficacy of Intervention and Diagnostic), and offer suggestions on optimal study design and analytic methods for use in OA investigations. CONCLUSION: The BIPED classification provides specific biomarker definitions with the goal of improving our ability to develop and analyze OA biomarkers, and to communicate these advances within a common framework.
Minimum Quench Energy Of Nb$_3$Sn Wires With High Specific Heat Tape
Creators: name: Barzi, E.
name: Novitsky, I.
name: Turrioni, D.
name: Zlobin, A. V.
name: Peng, X.
name: Tomsic, M.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: A major problem of state-of-the-art Nb$_3$Sn accelerator magnets is their long training due to thermo-mechanical perturbations. Increasing the specific heat, $C_p$, of the Rutherford cable would reduce and/or eliminate training by limiting the coils temperature rise. This paper studies feasibility of increasing the $C_p$ of Rutherford-type cables by using thin composite Cu/$Gd_2$O$_3$ and Cu/$Gd_2$O$_2$S tapes produced by Hyper Tech Research, Inc. The tape can be either wrapped around the cable, placed on the cable wide faces under the insulation, and/or inserted as a core. Wire samples outfitted with these high-$C_p$ ribbons, or tapes, were prepared and tested at FNAL for their Minimum Quench Energy (MQE). At 90%I$_c$ and 15 T, the average gain of MQE of the Nb$_3$Sn wire soldered to the Cu/$Gd_2$O$_2$S 55 micrometer thick ribbon was 2.5, and further increased at larger transport currents.
Estimation of parameters of the logistic exponential distribution under progressive type-I hybrid censored sample
Creators: name: Dutta, Subhankar
name: Kayal, Suchandan
Publisher: name: arXiv
Year: 2021
Subjects: subject: Applications (stat.AP)
subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences
subject: 62N02, 62F10, 62F15

description: The paper addresses the problem of estimation of the model parameters of the logistic exponential distribution based on progressive type-I hybrid censored sample. The maximum likelihood estimates are obtained and computed numerically using Newton-Raphson method. Further, the Bayes estimates are derived under squared error, LINEX and generalized entropy loss functions. Two types (independent and bivariate) of prior distributions are considered for the purpose of Bayesian estimation. It is seen that the Bayes estimates are not of explicit forms.Thus, Lindley's approximation technique is employed to get approximate Bayes estimates. Interval estimates of the parameters based on normal approximate of the maximum likelihood estimates and normal approximation of the log-transformed maximum likelihood estimates are constructed. The highest posterior density credible intervals are obtained by using the importance sampling method. Furthermore, numerical computations are reported to review some of the results obtained in the paper. A real life dataset is considered for the purpose of illustrations.