cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
CERTEZZA SCIENTIFICA E CERTEZZA PROCESSUALE NELLA RESPONSABILITA' PENALE DEL MEDICO
Creators: name: GIANNANGELI, ELIO
Publisher: name: Universit� degli Studi di Milano
Year: 2013

description: Il presente lavoro si propone di analizzare le problematiche sottese all?accertamento della responsabilit� penale colposa del medico, con particolare riferimento al rapporto di tensione esistente tra le esigenze di stretta legalit� ed il carattere aperto del tipo colposo , nonch� ? in stretta connessione ? tra il principio di determinatezza ed i limiti del sapere scientifico. Si tratta, come � evidente, di tematiche classiche del diritto penale, che per� in campo medico si manifestano in tutta la loro drammaticit� per le immediate ripercussioni pratiche che determinano: la indisponibilit� di un parametro normativo realmente utile a informare preventivamente di contenuto cautelare il precetto colposo, unita alla incertezza del sapere scientifico impiegato successivamente per condurre l?accertamento processuale, attribuiscono infatti al giudice la funzione ? legislativa ? di tipizzare il fatto di reato senza gli strumenti per valutarne poi la sussistenza.
title: Small bowel obstruction (SBO), beyond the common causes.
Creators: name: Maldonado Schoijet, Ignacio
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Abdomen
subject: Pelvis
subject: Small bowel
subject: CT
subject: CT-High Resolution
subject: Diagnostic procedure
subject: Obstruction / Occlusion

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Review the key imaging features of the SBO in MDCT. Differentiate the common and uncommon causes of SBO in MDCT. Classify the infrequent causes of SBO in extrinsic, intrinsic and...
Fabrication of Massive Sheets of Single Layer Patterned Arrays Using Lipid Directed Reengineered Phi29 Motor Dodecamer
Creators: name: Xiao, Feng
name: Guo, Peixuan
name: Wang, Joseph Che Yen
name: Holland Cheng, R.
name: Schoen, Peter
name: Sun, Jinchuan
name: Coban, Oana
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The bottom-up assembly of patterned arrays is an exciting and important area in current nanotechnology. Arrays can be engineered to serve as components in chips for a virtually inexhaustible list of applications ranging from disease diagnosis to ultra-high-density data storage. Phi29 motor dodecamer has been reported to form elegant multilayer tetragonal arrays. However, multilayer protein arrays are of limited use for nanotechnological applications which demand nanoreplica or coating technologies. The ability to produce a single layer array of biological structures with high replication fidelity represents a significant advance in the area of nanomimetics. In this paper, we report on the assembly of single layer sheets of reengineered phi29 motor dodecamer. A thin lipid monolayer was used to direct the assembly of massive sheets of single layer patterned arrays of the reengineered motor dodecamer. Uniform, clean and highly ordered arrays were constructed as shown by both transmission electron microscopy and atomic force microscopy imaging.
title: The Chiari I deformity: A concept still changing after 100 years of investigation
Creators: name: Gadde, Judith
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Cerebrospinal fluid
subject: Diagnostic procedure
subject: MR
subject: Paediatric
subject: Neuroradiology spine

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To describe the proposed etiologies of Chiari I deformity, as well as the recent transition from the use of the term "malformation" to "deformity". To describe and illustrate the spectrum of structural and physiological imaging findings associated...
MPEC 2024-R186 : 2024 RK7
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 RK7

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
title: To much of a good thing! Overuse sports injuries in children.
Creators: name: Vieira, Ana
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Athletic injuries
subject: Diagnostic procedure
subject: Ultrasound
subject: MR
subject: Digital radiography
subject: Paediatric
subject: Musculoskeletal system

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Recognize the importance of overuse injuries related to sports in a pediatric population Describe different types of musculoskeletal injuries related to sports in children and adolescents Imaging features on MRI, X-ray and...
DUAL ROLE OF SNAP-25 AT PRE- AND POST-SYNAPTIC LEVEL DURING DEVELOPMENT
Creators: name: FOSSATI, GIULIANA
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: Impairment of synaptic function can lead to neurological and psychiatric disorders collectively referred to as synaptopathies. SNAP-25, a SNARE protein controlling synaptic vesicle exocytosis and fundamental presynaptic functions, is implicated in several brain pathologies and, indeed, brain areas of psychiatric patients often display reduced SNAP-25 expression. We observed that halved SNAP-25 levels at 13?14DIV not only fail to impair synaptic transmission, but instead enhance evoked glutamatergic neurotransmission. This effect is probably dependent on presynaptic voltage-gated calcium channel activity and it is not followed by changes in spontaneous quantal events or in the pool of readily releasable synaptic vesicles. Notably, synapses of neurons with reduced SNAP-25 levels show paired-pulse depression as opposed to paired-pulse facilitation occurring in their wild-type counterpart. These phenotypes disappear with synapse maturation, where instead a reduction of evoked glutamatergic transmission and mEPSC amplitude emerge in heterozygous neurons thus suggesting the onset of a postsynaptic defect. In fact, it has been recently reported that a peculiar postsynaptic SNARE complex is required for long-term potentiation; however, the role of SNAP-25 in this process is not completely understood. We recently demonstrated that acute down-regulation of SNAP-25 in vitro affects spine morphogenesis through binding to p140Cap, thus suggesting that the protein may exert a structural role at the postsynaptic level. Here we demonstrate that in vivo acute down-regulation of SNAP-25 in CA1 hippocampal neurons affects spine number and morphology and causes a specific reduction of the postsynaptic protein PSD-95. Consistently, hippocampal neurons from SNAP-25 het mice show a flawed maturation of postsynaptic specializations, reduced densities of dendritic spines and defective PSD-95 clustering. These effects do not stem from impaired presynaptic function, but as a direct consequence of reduced SNAP-25 levels in the postsynaptic compartment. By co-immunoprecipitation and LUMIER Assay, we show that SNAP-25, PSD-95 and p140Cap are part of the same molecular complex in the brain, with p140Cap being intrinsically capable to bind either to SNAP-25 and PSD-95. These data provide new mechanistic insights as to SNAP-25 involvement in synaptopathies that go beyond the protein?s known roles in presynaptic function.
(101213) Charles Edwin Curtis
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: CT Hypoperfusion Complex: CT signs of hypovolaemic shock after major trauma
Creators: name: Power, Stephen
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Trauma
subject: Haemorrhage
subject: Diagnostic procedure
subject: CT-Angiography
subject: CT
subject: Vascular
subject: Trauma
subject: Emergency

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The purpose of this education exhibit isto describe a spectrum of specific abdominal CT imagingfeatures which can help to identify patients experiencing poorly compensated hypovolaemic shock after major...
Ground-state and spectral signatures of cavity exciton-polariton condensates
Creators: name: Phan, Van-Nham
name: Becker, Klaus W.
name: Fehske, Holger
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We propose a projector-based renormalization framework to study exciton-polariton Bose-Einstein condensation in a microcavity matter-light system. Treating Coulomb interaction and electron-hole/photon coupling effects on an equal footing we analyze the ground-state properties of the exciton polariton model according to the detuning and the excitation density. We demonstrate that the condensate by its nature shows a crossover from an excitonic insulator (of Bose-Einstein respectively BCS type) to a polariton and finally photonic condensed state as the excitation density increases at large detuning. If the detuning is weak polariton or photonic phases dominate. While in both cases a notable renormalization of the quasiparticle band structure occurs that strongly affects the coherent part of the excitonic luminescence, the incoherent wavevector-resolved luminescence spectrum develops a flat bottom only for small detuning.
description: 18 pages, 17 figures, final version
(101214) Amelia Maria Curtis
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 2 of Evaluation of alpaca tracheal explants as an ex vivo model for the study of Middle East respiratory syndrome coronavirus (MERS-CoV) infection
Creators: name: Te, Nigeer
name: Rodon, Jordi
name: Creve, Rhea
name: Pérez, Mónica
name: Segalés, Joaquim
name: Vergara-Alert, Júlia
name: Bensaid, Albert
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology
subject: Computational Biology

description: Additional file 2: MERS-CoV N protein detection by IHC in ATE.
(101210) Unknown Mills
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Morphing Low-Affinity Ligands into High-Avidity Nanoparticles by Thermally Triggered Self-Assembly of a Genetically Encoded Polymer
Creators: name: Chilkoti, Ashutosh
name: Liu, Rihe
name: Valencia, C. Alexander
name: Simnick, Andrew J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Multivalency is the increase in avidity resulting from the simultaneous interaction of multiple ligands with multiple receptors. This phenomenon, seen in antibody-antigen and virus-cell membrane interactions, is useful in designing bioinspired materials for targeted delivery of drugs or imaging agents. While increased avidity offered by multivalent targeting is attractive, it can also promote nonspecific receptor interaction in non-target tissues, reducing the effectiveness of multivalent targeting. Here, we present a thermal targeting strategy - Dynamic Affinity Modulation (DAM) - using Elastin-like polypeptide diblock copolymers (ELPBCs) that self-assemble from a low-affinity to high-avidity state by a tunable thermal “switch”, thereby restricting activity to the desired site of action. We used an in vitro cell binding assay to investigate the effect of the thermally triggered self-assembly of these ELPBCs on their receptor-mediated binding and cellular uptake. The data presented herein show that: (1) ligand presentation does not disrupt ELPBC self-assembly; (2) both multivalent ligand presentation and upregulated receptor expression are needed for receptor-mediated interaction; (3) increased size of the hydrophobic segment of the block copolymer promotes multivalent interaction with membrane receptors, potentially due to changes in the nanoscale architecture of the micelle; and (4) nanoscale presentation of the ligand is important, as presentation of the ligand by micron-sized aggregates of an ELP showed a low level of binding/uptake by receptor-positive cells compared to its presentation on the corona of a micelle. These data validate the concept of thermally triggered DAM, and provide rational design parameters for future applications of this technology for targeted drug delivery.
title: Ventriculitis and its Different Patterns: an Imaging Aprouch
Creators: name: FEITOSA, THIAGO
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Neuroradiology brain
subject: MR
subject: CT
subject: Education
subject: Infection
subject: Inflammation

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To describe the main imaging findings of ventriculitis and to evaluate specific changes related with its different...
Folate-Targeted Polymeric Nanoparticle Formulation of Docetaxel Is an Effective Molecularly Targeted Radiosensitizer with Efficacy Dependent on the Timing of Radiotherapy
Creators: name: Sukumar, Rohit
name: Chen, Ronald C.
name: Li, Chenxi
name: Cummings, Natalie D.
name: Werner, Michael E.
name: Wang, Andrew Z.
name: Karve, Shrirang
name: Napier, Mary E.
name: Cox, Adrienne D.
name: Copp, Jonathan A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Nanoparticle (NP) chemotherapeutics hold great potential as radiosensitizers. Their unique properties, such as preferential accumulation in tumors and their ability to target tumors through molecular targeting ligands, are ideally suited for radiosensitization. We aimed to develop a molecularly targeted nanoparticle formulation of docetaxel (Dtxl) and evaluate its property as a radiosensitizer. Using a biodegradable and biocompatible lipid-polymer NP platform and folate as a molecular targeting ligand, we engineered a folate-targeted nanoparticle (FT-NP) formulation of Dtxl. These NPs have sizes of 72±4 nm and surface charges of −42±8 mV. Using folate receptor over-expressing KB cells and folate receptor low HTB-43 cells, we showed folate-mediated intracellular uptake of NPs. In vitro radiosensitization studies initially showed FT-NP is less effective than Dtxl as a radiosensitizer. However, the radiosensitization efficacy is dependent on the timing of radiotherapy. In vitro radiosensitization conducted with irradiation given at the optimal time (24 hours) showed FT-NP Dtxl is as effective as Dtxl. When FT-NP Dtxl is compared to Dtxl and non-targeted nanoparticle (NT-NP) Dtxl in vivo, FT-NP was found to be significantly more effective than Dtxl or NT-NP Dtxl as a radiosensitizer. We also confirmed that radiosensitization is dependent on timing of irradiation in vivo. In summary, FT-NP Dtxl is an effective radiosensitizer in folate-receptor over-expressing tumor cells. Time of irradiation is critical in achieving maximal efficacy with this nanoparticle platform. To the best of our knowledge, our report is the first to demonstrate the potential of molecularly targeted NPs as a promising new class of radiosensitizers.
Influence of Scaffold Size on Bactericidal Activity of Nitric Oxide-Releasing Silica Nanoparticles
Creators: name: Schoenfisch, Mark H.
name: Slomberg, Danielle L.
name: Rao, Kavitha S.
name: Carpenter, Alexis W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: A reverse microemulsion synthesis was used to prepare amine functionalized silica nanoparticles of three distinct sizes (i.e., 50, 100, and 200 nm) with identical amine concentrations. The resulting hybrid nanoparticles, consisting of N-(6 aminohexyl) aminopropyltrimethoxysilane and tetraethoxysilane, were highly monodisperse in size. N-diazeniumdiolate nitric oxide (NO) donors were subsequently formed on secondary amines while controlling reaction conditions to keep the total amount of nitric oxide (NO) released constant for each particle size. The bactericidal efficacy of the NO releasing nanoparticles against Pseudomonas aeruginosa increased with decreasing particle size. Additionally, smaller diameter nanoparticles were found to associate with the bacteria at a faster rate and to a greater extent than larger particles. Neither control (non-NO-releasing) nor NO releasing particles exhibited toxicity towards L929 mouse fibroblasts at concentrations above their respective minimum bactericidal concentrations. This study represents the first investigation of the bactericidal efficacy of NO-releasing silica nanoparticles as a function of particle size.
(101212) Eleanor Martin
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Transradial access for non-coronary interventions
Creators: name: Schotten, Sebastian
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Education and training
subject: Arterial access
subject: Catheter arteriography
subject: Interventional vascular

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The potential benefits of transradial access for interventional radiology procedures Patient selection and pre-procedure workup Room setup and material selection How to safely perform transradial interventions How to deal with problems and...
title: Variations of hepatic vascularization: correlation of MDCT and MRI images with free-hand drawings
Creators: name: Mammino, Luca
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Anatomy
subject: Vascular
subject: Arteries / Aorta
subject: CT
subject: CT-Angiography
subject: MR
subject: Education
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The aim of this exhibit is to describe anatomic variants of hepatic vascularization, correlating schematic free-hand drawings with MDCT and/or MR images and volume-rendering techniques. In addition, this pictorial exhibit focuses on clinical and...
(α-NaYbF 4 :Tm 3+ )/CaF 2 Core/Shell Nanoparticles with Efficient Near-Infrared to Near-Infrared Upconversion for High-Contrast Deep Tissue Bioimaging
Creators: name: Kutikov, Artem
name: Han, Gang
name: Li, Zhipeng
name: Agren, Hans
name: Patel, Nayan J.
name: Pandey, Ravindra K.
name: Song, Jie
name: Chen, Guanying
name: Ohulchanskyy, Tymish Y.
name: Prasad, Paras N.
name: Shen, Jie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: We describe the development of novel and biocompatible core/shell (α-NaYbF4:Tm3+)/CaF2 nanoparticles which exhibit highly efficient NIRin-NIRout upconversion (UC) for high contrast and deep bioimaging. When excited at ~980 nm, these nanoparticles emit photoluminescence (PL) peaked at ~800 nm. The quantum yield of this UC PL under low power density excitation (~0.3 W/cm2) is 0.6±0.1%. This high UC PL efficiency is realized by suppressing surface quenching effects via hetero-epitaxial growth of a biocompatible CaF2 shell which results in a 35-fold increase in the intensity of UC PL from the core. Small animal whole-body UC PL imaging with exceptional contrast (signal-to-background ratio of 310) is shown using BALB/c mice intravenously injected with aqueously dispersed nanoparticles (700 pmol/kg). High-contrast UC PL imaging of deep tissues is also demonstrated, using a nanoparticle-loaded synthetic fibrous mesh wrapped around rat femoral bone, and a cuvette with nanoparticle aqueous dispersion - covered with a 3.2-cm thick animal tissue (pork).
title: Role of CT angiography in the management of patients with acute ischemic stroke
Creators: name: Rusina, Matej
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Acute
subject: Decision analysis
subject: CT-Angiography
subject: Neuroradiology brain
subject: Interventional vascular

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Thepurposeofthis educational posteris toshow the role of CT angiography (CTA) in the diagnostic process of acute ischemic stroke and its importance in endovascular therapy planning and to summarize variousCTA findingsin patients with acute ischemic...
An intrinsic and exterior form of the Bianchi identities
Creators: name: Do, Thoan
name: Prince, Geoff
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 53B05, 53C05, 53C12, 53D10

description: We give an elegant formulation of the structure equations (of Cartan) and the Bianchi identities in terms of exterior calculus without reference to a particular basis and without the exterior covariant derivative. This approach allows both structure equations and the Bianchi identities to be expressed in terms of forms of arbitrary degree. We demonstrate the relationship with both the conventional vector version of the Bianchi identities and to the exterior covariant derivative approach. Contact manifolds, codimension one foliations and the Cartan form of classical mechanics are studied as examples of its flexibility and utility.
Additional file 1 of Preoperative inflammatory markers as prognostic predictors after hepatocellular carcinoma resection: data from a western referral center
Creators: name: Silva, João Paulo Maciel
name: Coelho, Fabricio Ferreira
name: Cassenote, Alex Jones Flores
name: Jeismann, Vagner Birk
name: Fonseca, Gilton Marques
name: Kruger, Jaime Arthur Pirola
name: de Meira Júnior, José Donizeti
name: Nahas, Sérgio Carlos
name: Herman, Paulo
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 1: Figure S1. Overall and disease-free survival of patients with hepatocellular carcinoma included in the study (N=161). Figure S2. Overall survival of patients with hepatocellular carcinoma < 5 cm (Group 1) with low (blue) and high (red) neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR). Figure S3. Disease-free survival of patients with hepatocellular carcinoma < 5 cm (Group 1) with low (blue) and high (red) neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR). Figure S4. Overall survival of patients with hepatocellular carcinoma between 5 and 10 cm (Group 2) with low (blue) and high (red) neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR). Figure S5. Disease-free survival of patients with hepatocellular carcinoma between 5 and 10 cm (Group 2) with low (blue) and high (red) neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR). Figure S6. Overall survival of patients with hepatocellular carcinoma > 10 cm (Group 3) with low (blue) and high (red) neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR). Figure S7. Disease-free survival of patients with hepatocellular carcinoma > 10 cm (Group 3) with low (blue) and high (red) neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR). Table S1. Baseline characteristics of patients with low (≤ 1.715) and high (> 1.715) neutrophil-to-lymphocyte ratio (NLR). Table S2. Baseline characteristics of patients with low (≤ 2.475) and high (> 2.475) neutrophil-to-lymphocyte ratio (NLR). Table S3. Baseline characteristics of patients with low (≤ 100.25) and high (> 100.25) platelet-to-lymphocyte ratio (PLR)
A Device for Performing Lateral Conductance Measurements on Individual Double-Stranded DNA Molecules
Creators: name: Mair, Chad E.
name: Ramsey, J. Michael
name: Woodson, Michael E.
name: Menard, Laurent D.
name: Alarie, Jean Pierre
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: A nanofluidic device is described that is capable of electrically monitoring the driven translocation of DNA molecules through a nanochannel. This is achieved by intersecting a long transport channel with a shorter orthogonal nanochannel. The ionic conductance of this transverse nanochannel is monitored while DNA is electrokinetically driven through the transport channel. When DNA passes the intersection, the transverse conductance is altered, resulting in a transient current response. In 1 M KCl solutions, this was found to be a current enhancement of 5–25%, relative to the baseline transverse ionic current. Two different device geometries were investigated. In one device, the DNA was detected after it was fully inserted into and translocating through the transport nanochannel. In the other device, the DNA was detected while it was in the process of entering the nanochannel. It was found that these two conditions are characterized by different transport dynamics. Simultaneous optical and electrical monitoring of DNA translocation confirmed that the transient events originated from DNA transport through the nanochannel intersection.
title: Safety aspects of IRE and MWA for ablation of hepatic malignancies: Increased risk for hemorrhage with IRE?
Creators: name: Schotten, Sebastian
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Neoplasia
subject: Safety
subject: Ablation procedures
subject: CT
subject: Liver
subject: Interventional non-vascular

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Irreversible electroporation (IRE) has emerged as an alternative method to thermal ablation for the treatment of tumors in several organs. There is some evidence that thepreferentialnon-thermalcell destruction of IRE might reducethe damage of nearby...
A Highly Efficient Synthetic Vector: Nonhydrodynamic Delivery of DNA to Hepatocyte Nuclei in Vivo
Creators: name: Haynes, Matthew T.
name: Wang, Yuhua
name: Hu, Yunxia
name: Huang, Leaf
name: Liu, Feng
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Multifunctional membrane-core nanoparticles, composed of calcium phosphate cores, arginine-rich peptides, cationic and PEGylated lipid membranes, and galactose targeting ligands, have been developed as synthetic vectors for efficient nuclear delivery of plasmid DNA and subsequent gene expression in hepatocytes in vivo. Targeted particles exhibited rapid and extensive hepatic accumulation and were predominantly internalized by hepatocytes, while the inclusion of such peptides in LCP was sufficient to elicit high degrees of nuclear translocation of plasmid DNA. Monocyclic CR8C significantly enhanced in vivo gene expression over ten-fold more than linear CR8C, likely due to a release-favoring mechanism of the DNA/peptide complex. Though 100-fold lower in activity than that achieved via hydrodynamic injection, this formulation presents as a much less invasive alternative. To our knowledge, this is the most effective synthetic vector for liver gene transfer.
Pemanfaatan Limbah Tempurung Kelapa Menjadi Biobriket Sebagai Energi Terbarukan di Desa Pancur Keritang
Creators: name: Muhammad Syafi'i, Wan Salma Nurkhairin Fitri, Gusti Marton Ferlanda, Muhammmad Ikhsan Fadilah, Agne Fadhilah, Deswita Fitri, Norasida Norasida, Ririn Ageng Syalsabil, Ulvia Nur'Aini
Publisher: name: Zenodo
Year: 2024

description: Peningkatan kebutuhan energi di Indonesia semakin meningkat seiring dengan pertumbuhan populasi dan ekonomi, sementara sumber energi utama masih didominasi oleh bahan bakar fosil yang tidak terbarukan. Tempurung kelapa sebagai limbah pertanian memiliki potensi untuk diolah menjadi sumber energi alternatif yang terbarukan. Desa Pancur Keritang, Kabupaten Inhil, memiliki kelapa yang melimpah namun limbah tempurung kelapanya belum dimanfaatkan secara optimal. Pengolahan tempurung kelapa menjadi briket merupakan salah satu solusi untuk memanfaatkan limbah ini dan menghasilkan energi yang ramah lingkungan. Melalui kegiatan sosialisasi dan pelatihan oleh mahasiswa KKN UNRI 2024 di Pondok Pesantren Khairul Ummah 4 Desa Pancur Keritang, diberikan pengetahuan tentang proses pembuatan briket dari arang tempurung kelapa. Proses ini meliputi karbonisasi tempurung kelapa, penghancuran arang, pencampuran dengan perekat kanji, pencetakan, dan pengeringan briket. Hasil kegiatan ini diharapkan dapat meningkatkan pemahaman dan kesadaran tentang pentingnya potensi pemanfaatan limbah sebagai energi terbarukan serta mengurangi pencemaran lingkungan.
(101209) Mary Ann Mills
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Electronic Property Tomography for differentiating malignant from benign breast lesions
Creators: name: Tsuchiya, Keiko
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Cancer
subject: Diagnostic procedure
subject: MR
subject: Breast

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Learning objectives: To describe what isElectronic Property Tomography (EPT)including the concept of EPT and basic technique of making EPT To discuss the benefits of performing EPT in differentiating malignant from benign breast lesions by providing...
Anisotropic magnetoresistance driven by surface spin orbit scattering
Creators: name: Zhang, Steven S. -L.
name: Vignale, Giovanni
name: Zhang, Shufeng
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: In a bilayer consisting of an insulator (I) and a ferromagnetic metal (FM), interfacial spin orbit scattering leads to spin mixing of the two conducting channels of the FM, which results in an unconventional anisotropic magnetoresistance (AMR). We theoretically investigate the magnetotransport in such bilayer structures by solving the spinor Boltzmann transport equation with generalized Fuchs-Sondheimer boundary condition that takes into account the effect of spin orbit scattering at the interface. We find that the new AMR exhibits a peculiar angular dependence which can serve as a genuine experimental signature. We also determine the dependence of the AMR on film thickness as well as spin polarization of the FM.
description: 6 pages, 3 figures
Asymptotic soliton like solutions to the singularly perturbed Benjamin-Bona-Mahony equation with variable coefficients
Creators: name: Samoilenko, Valerii
name: Samoilenko, Yuliia
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: 35C20, 35Q53, 35B25

description: The paper deals with a problem of asymptotic soliton like solutions to the Benjamin-Bona-Mahony (BBM) equaion with a small parameter at the highest derivative and variable coefficients depending on the variables $x$, $t$ as well as a small parameter. There is proposed an algorithm of constructing the solutions and there are proved theorems on accuracy with which the solutions satisfy the BBM equation.
description: 19 pages, 44 references
Additional file 1 of Prolonged postoperative length of stay may be a valuable marker for susceptibility to relapse beyond established risk factors in patients with stage III colon cancer
Creators: name: Emland, Frans
name: Taflin, Helena
name: Carlsson, Göran
name: Ljungman, David
name: Lindskog, Elinor Bexe
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Marine Biology
subject: Cancer

description: Additional file 1: Table S1. Clinical characteristics of stage III colon cancer patients by timing of adjuvant chemotherapy (< 8 weeks or > 8 weeks).
Injectable Nano-Network for Glucose-Mediated Insulin Delivery
Creators: name: Anderson, Daniel G.
name: Dang, Tram T.
name: Cheng, Hao
name: Langer, Robert S.
name: Zhang, Yunlong
name: Veiseh, Omid
name: Gu, Zhen
name: Aimetti, Alex A.
name: Wang, Qun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Diabetes mellitus, a disorder of glucose regulation, is a global burden affecting 366 million people across the world. An artificial “closed-loop” system able to mimic pancreas activity and release insulin in response to glucose level changes has the potential to improve patient compliance and health. Herein we develop a glucose-mediated release strategy for the self-regulated delivery of insulin using an injectable and acid-degradable polymeric network. Formed by electrostatic interaction between oppositely charged dextran nanoparticles loaded with insulin and glucose-specific enzymes, the nanocomposite-based porous architecture can be dissociated and subsequently release insulin in a hyperglycemic state through the catalytic conversion of glucose into gluconic acid. In vitro insulin release can be modulated in a pulsatile profile in response to glucose concentrations. In vivo studies validated that these formulations provided improved glucose control in type 1 diabetic mice subcutaneously administered with a degradable nano-network. A single injection of the developed nano-network facilitated stabilization of the blood glucose levels in the normoglycemic state (<200 mg/dL) for up to 10 days.
(101211) Henry Martin
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Thermodynamics of computing with circuits
Creators: name: Wolpert, David Hilton
name: Kolchinsky, Artemy
Publisher: name: arXiv
Year: 2018
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Computational Complexity (cs.CC)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences
subject: F.1; F.2.3
subject: 03D15

description: Digital computers implement computations using circuits, as do many naturally occurring systems (e.g., gene regulatory networks). The topology of any such circuit restricts which variables may be physically coupled during the operation of a circuit. We investigate how such restrictions on the physical coupling affects the thermodynamic costs of running the circuit. To do this we first calculate the minimal additional entropy production that arises when we run a given gate in a circuit. We then build on this calculation, to analyze how the thermodynamic costs of implementing a computation with a full circuit, comprising multiple connected gates, depends on the topology of that circuit. This analysis provides a rich new set of optimization problems that must be addressed by any designer of a circuit, if they wish to minimize thermodynamic costs.
description: 26 pages (6 of appendices), 5 figures
title: Utility of diagnostic imaging in cerebral revascularization by encephalo-duro-arterial-synangiosis.
Creators: name: Andrade, Santiago
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Ischaemia / Infarction
subject: Arteriovenous malformations
subject: Treatment effects
subject: MR-Angiography
subject: CT-Angiography
subject: CT
subject: Vascular
subject: Neuroradiology brain

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Ilustrate the usefulness of diagnostic imaging in diagnosis, surgical planning and postoperative cerebral revascularization by encephalo-duro-arterial-synangiosis in patients with cerebral ischemia asociated to cerebral proliferative...
title: The role of MRI in the diagnosis of complications in the post-operative lumbar spine.
Creators: name: Rivera Alcántara, Luz Altagracia
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Musculoskeletal spine
subject: Neuroradiology spine
subject: MR
subject: Education
subject: eLearning
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: All surgical intervention is not free of complications and more when they are as complex as the spine. The best test to evaluate the postsurgical column is MRI, especially for its technical considerations. We are particularly interested in two...
Redshift-space distortions with wide angular separations
Creators: name: Reimberg, Paulo H. F.
name: Bernardeau, Francis
name: Pitrou, Cyril
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Redshift-space distortions are generally considered in the plane parallel limit, where the angular separation between the two sources can be neglected. Given that galaxy catalogues now cover large fractions of the sky, it becomes necessary to consider them in a formalism which takes into account the wide angle separations. In this article we derive an operational formula for the matter correlators in the Newtonian limit to be used in actual data sets, both in configuration and in Fourier spaces without relying on a plane-parallel approximation. We then recover the plane-parallel limit not only in configuration space where the geometry is simpler, but also in Fourier space, and we exhibit the first corrections that should be included in large surveys as a perturbative expansion over the plane-parallel results. We finally compare our results to existing literature, and show explicitly how they are related.
description: Small modifications. Matches published version
title: Radiology as the answer key for diagnostic and treatment of high-flow priapism
Creators: name: Ninčević, Josip
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Interventional vascular
subject: Genital / Reproductive system male
subject: Vascular
subject: Ultrasound-Colour Doppler
subject: Catheter arteriography
subject: Ultrasound-Spectral Doppler
subject: Embolisation
subject: Fistula

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The goals of this educational exhibit are as follows: to explain the main distinction in etiopathogenesis between low-flow (veno-occlusive, ischemic) and high-flow (arterial, nonischemic ) type of priapism to show the role of color doppler...
Lipid-Coated Cisplatin Nanoparticles Induce Neighboring Effect and Exhibit Enhanced Anticancer Efficacy
Creators: name: Wang, Yuhua
name: Lin, C. Michael
name: Zhang, Yuan
name: Huang, Leaf
name: Miao, Lei
name: Guo, Shutao
name: Xu, Zhenghong
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Encapsulation of cisplatin (CDDP) into nanoparticles (NPs) with high drug loading and encapsulation efficiency has been difficult due to the poor solubility of CDDP. However, this barrier has been overcome with a reverse microemulsion method appropriating CDDP’s poor solubility to our advantage promoting the synthesis of a pure cisplatin nanoparticle with a high drug loading capacity (approximately 80.8wt%). Actively targeted CDDP NPs exhibited significant accumulation in human A375M melanoma tumor cells in vivo. In addition, CDDP NPs achieved potent anti-tumor efficacy through the neighboring effect at a dose of 1 mg/kg when injected weekly via IV without inducing nephrotoxicity. The neighboring effect regards an observation made in vivo when the tumor cells that took up CDDP NPs released active drug following apoptosis. Via diffusion, surrounding cells that were previously unaffected showed intake of the released drug and their apoptosis soon followed. This observation was also made in vitro when A375M melanoma tumor cells incubated with CDDP NPs exhibited release of active drug and induced apoptosis on untreated neighboring cells. However, the neighboring effect was unique to rapidly proliferating tumor cells. Liver functional parameters and H&E staining of liver tissue in vivo failed to detect any difference between CDDP NP treated and control groups in terms of tissue health. By simultaneously promoting an increase in cytotoxicity and a lesser degree of side effects over free CDDP, CDDP NPs show great therapeutic potential with lower doses of drug while enhancing anti-cancer effectiveness.
(101205) Alice Wilkes Woodhill Davies
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Observations of Carbon Nanotube Oxidation in an Aberration-Corrected Environmental Transmission Electron Microscope
Creators: name: Koh, Ai Leen
name: Zhou, Otto
name: Sinclair, Robert
name: Gidcumb, Emily
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: We report the first direct study on the oxidation of carbon nanotubes at the resolution of an aberration-corrected environmental transmission electron microscope (ETEM), as we locate and identify changes in the same nanotubes as they undergo oxidation at increasing temperatures in-situ in the ETEM. Contrary to earlier reports that CNT oxidation initiates at the end of the tube and proceeds along its length, our findings show that only the outside graphene layer is being removed and on occasion, the interior inner wall is oxidized, presumably due to oxygen infiltrating into the hollow nanotube through an open end or breaks in the tube. We believe that this work provides the foundation for much scientific understanding of the mechanism underlying the nanotube oxidation process, as well as guidelines to manipulate their structure or prevent their oxidation.