cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Renormalization scheme dependence of the two-loop QCD corrections to the neutral Higgs-boson masses in the MSSM
Creators: name: Borowka, S.
name: Hahn, T.
name: Heinemeyer, S.
name: Heinrich, G.
name: Hollik, W.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Reaching a theoretical accuracy in the prediction of the lightest MSSM Higgs-boson mass, M_h, at the level of the current experimental precision requires the inclusion of momentum-dependent contributions at the two-loop level. Recently two groups presented the two-loop QCD momentum-dependent corrections to Mh [1,2], using a hybrid on-shell--DRbar scheme, with apparently different results. We show that the differences can be traced back to a different renormalization of the top-quark mass, and that the claim in [2] of an inconsistency in [1] is incorrect. We furthermore compare consistently the results for M_h obtained with the top-quark mass renormalized on-shell and DRbar. The latter calculation has been added to the FeynHiggs package and can be used to estimate missing higher-order corrections beyond the two-loop level.
description: Discussion of Higgs field renormalization effects extended. arXiv admin note: text overlap with arXiv:1404.7074
Dynamic Regulation of Histone H3 Methylated at Lysine 79 within a Tissue-specific Chromatin Domain
Creators: name: Kiekhaefer, Carol M.
name: Im, Hogune
name: Bresnick, Emery H.
name: Feng, Qin
name: Park, Changwon
name: Choi, Kyunghee
name: Johnson, Kirby D.
name: Zhang, Yi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Post-translational modifications of individual lysine residues of core histones can exert unique functional consequences. For example, methylation of histone H3 at lysine 79 (H3-meK79) has been implicated recently in gene silencing in Saccharomyces cerevisiae. However, the distribution and function of H3-meK79 in mammalian chromatin are not known. We found that H3-meK79 has a variable distribution within the murine beta-globin locus in adult erythroid cells, being preferentially enriched at the active betamajor gene. By contrast, acetylated H3 and H4 and H3 methylated at lysine 4 were enriched both at betamajor and at the upstream locus control region. H3-meK79 was also enriched at the active cad gene, whereas the transcriptionally inactive loci necdin and MyoD1 contained very little H3-meK79. As the pattern of H3-meK79 at the beta-globin locus differed between adult and embryonic erythroid cells, establishment and/or maintenance of H3-meK79 was developmentally dynamic. Genetic complementation analysis in null cells lacking the erythroid and megakaryocyte-specific transcription factor p45/NF-E2 showed that p45/NF-E2 preferentially establishes H3-meK79 at the betamajor promoter. These results support a model in which H3-meK79 is strongly enriched in mammalian chromatin at active genes but not uniformly throughout active chromatin domains. As H3-meK79 is highly regulated at the beta-globin locus, we propose that the murine ortholog of Disruptor of Telomeric Silencing-1-like (mDOT1L) methyltransferase, which synthesizes H3-meK79, regulates beta-globin transcription.
(1722) Martha [Crossley]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
ESM_appendices from A new family of dissimilarity metrics for discrete character matrices that include inapplicable characters and its importance for disparity studies.
Creators: name: Hopkins, Melanie J.
name: John, Katherine St.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences
subject: 60301 Animal Systematics and Taxonomy
subject: 60310 Plant Systematics and Taxonomy

description: Appendices 1-4
Cavity-photon contribution to the effective interaction of electrons in parallel quantum dots
Creators: name: Gudmundsson, Vidar
name: Sitek, Anna
name: Abdullah, Nzar Rauf
name: Tang, Chi-Shung
name: Manolescu, Andrei
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: A single cavity photon mode is expected to modify the Coulomb interaction of an electron system in the cavity. Here we investigate this phenomena in a parallel double quantum dot system. We explore properties of the closed system and the system after it has been opened up for electron transport. We show how results for both cases support the idea that the effective electron-electron interaction becomes more repulsive in the presence of a cavity photon field. This can be understood in terms of the cavity photons dressing the polarization terms in the effective mutual electron interaction leading to nontrivial delocalization or polarization of the charge in the double parallel dot potential. In addition, we find that the effective repulsion of the electrons can be reduced by quadrupolar collective oscillations excited by an external classical dipole electric field.
description: PDF-LaTeX, RevTeX, 8 pages with 8 embedded PNG-figures
Supplementary Information -- Additional methods and translation details and supplementary analyses from Causal learning, counterfactual reasoning and pretend play: a cross-cultural comparison of Peruvian, mixed- and low-socioeconomic status U.S. children
Creators: name: Wente, Adrienne
name: Gopnik, Alison
name: Fernández Flecha, Mari
name: Garcia, Teresa
name: Buchsbaum, Daphna
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology
subject: 60801 Animal Behaviour
subject: FOS: Biological sciences

description: Pretend play universally emerges during early childhood and may support the development of causal inference and counterfactual reasoning. However, the amount of time spent pretending, the value that adults place on pretense and the scaffolding adults provide varies by both culture and socioeconomic status (SES). In middle class U.S. preschoolers, accuracy on a pretense-based causal reasoning task predicted performance on a similar causal counterfactual task. We explored the relationship between cultural environment, pretense and counterfactual reasoning in low-income Peruvian (N = 62) and low-income U.S. (N = 57) 3- to 4-year olds, and contrast findings against previous findings in an age matched, mixed-SES U.S. sample (N = 60). Children learned a novel causal relationship, then answered comparable counterfactual and pretense-based questions about the relationship. Children's responses for counterfactual and pretense measures differed across populations, with Peruvian and lower income U.S. children providing fewer causally consistent responses when compared to middle class U.S. children. Nevertheless, correlations between the two measures emerged in all populations. Across cohorts, children also provided more causally consistent answers during pretense than counterfactually. Findings strengthen the hypothesis that causal pretend play is related to causal counterfactual reasoning across cultural contexts, while also suggesting a role for systematic environmental differences.This article is part of the theme issue ‘Thinking about possibilities: mechanisms, ontogeny, functions and phylogeny’.
(1723) Frederick Talbot Baines
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
ESM_appendices from A new family of dissimilarity metrics for discrete character matrices that include inapplicable characters and its importance for disparity studies
Creators: name: Hopkins, Melanie J.
name: John, Katherine St.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences
subject: 60301 Animal Systematics and Taxonomy
subject: 60310 Plant Systematics and Taxonomy

description: Appendices 1-4
Ecto 5′-Nucleotidase and Nonspecific Alkaline Phosphatase: TWO AMP-HYDROLYZING ECTOENZYMES WITH DISTINCT ROLES IN HUMAN AIRWAYS
Creators: name: Hirsh, Andrew J.
name: Spychala, Josef
name: Boucher, Richard C.
name: Burch, Lauranell H.
name: Picher, Maryse
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: In human airways, extracellular adenosine regulates epithelial functions supporting mucociliary clearance, an important airway defense mechanism against bacterial infection. Thus, defining the mechanisms of adenosine generation is critical for elucidating the role of this nucleoside in airway homeostasis. In this study, we identified the source of adenosine on the mucosal surface of human airway epithelia. Polarized primary cultures of human nasal or bronchial epithelial cells were assayed for transepithelial transport, cytosolic and cell surface adenosine production. Ussing chamber experiments indicated that serosal 1 microM [(3)H]adenosine was not transported to the mucosal compartment. Messenger RNA for the cytosolic AMP-specific 5'-nucleotidase (CN-I) was not detected in human bronchial epithelial cells, suggesting that mucosal adenosine did not originate from intracellular pools. In contrast, extracellular 0.1 mm ATP was rapidly dephosphorylated into adenosine on the mucosal epithelial surface. We identified two ectonucleotidases that mediated the conversion of AMP to adenosine: ecto 5'-nucleotidase (ecto 5'-NT, CD73) and alkaline phosphatase (AP). Both mucosal and serosal epithelial surfaces displayed ecto 5'-NT activity (K(m) = 14 microM, V(max) = 0.5 nmol x min(-1) x cm(-2)), whereas AP activity was restricted to the mucosal surface (K(m,)(high) = 36 microM, V(max) = 1.2 nmol x min(-1) x cm(-2); K(m,)(low) = 717 microM, V(max) = 2.8 nmol x min(-1) x cm(-2)). In bronchial cultures and tissues, ecto 5'-NT accounted for >80% of total activity toward 0.01 mm AMP, compared with <15% for 5 mm AMP. The proximal airway AP isoform was identified as nonspecific AP (NS AP) by levamisole sensitivity and mRNA expression. The two ectoenzymes presented opposite airway distributions, ecto 5'-NT and NS AP mRNA dominating in higher and lower airways, respectively. Collectively, these experiments support a major role for extracellular nucleotide catalysis and for ecto 5'-NT and NS AP in the regulation of adenosine concentrations on airway surfaces.
title: Neuropeptide S Receptor Stimulation Excites Principal Neurons in Murine Basolateral Amygdala through a Calcium-Dependent Decrease in Membrane Potassium Conductance
Creators: name: Park, Sion
name: Flüthmann, Pia
name: Wolany, Carla
name: Goedecke, Lena
name: Spenner, Hannah Maleen
name: Budde, Thomas
name: Pape, Hans-Christian
name: Jüngling, Kay
Publisher: name: University of Muenster, Institutional Repository MIAMI
Year: 2023
Subjects: subject: 610 Medicine and health

description: Background: The neuropeptide S system, consisting of the 20 amino acid neuropeptide NPS and its G-protein-coupled receptor (GPCR) neuropeptide S receptor 1 (NPSR1), has been studied intensively in rodents. Although there is a lot of data retrieved from behavioral studies using pharmacology or genetic interventions, little is known about intracellular signaling cascades in neurons endogenously expressing the NPSR1. Methods: To elucidate possible G-protein-dependent signaling and effector systems, we performed whole-cell patch-clamp recordings on principal neurons of the anterior basolateral amygdala of mice. We used pharmacological interventions to characterize the NPSR1-mediated current induced by NPS application. Results: Application of NPS reliably evokes inward-directed currents in amygdalar neurons recorded in brain slice preparations of male and female mice. The NPSR1-mediated current had a reversal potential near the potassium reversal potential (EK) and was accompanied by an increase in membrane input resistance. GDP-β-S and BAPTA, but neither adenylyl cyclase inhibition nor 8-Br-cAMP, abolished the current. Intracellular tetraethylammonium or 4-aminopyridine reduced the NPS-evoked current. Conclusion: NPSR1 activation in amygdalar neurons inhibits voltage-gated potassium (K+) channels, most likely members of the delayed rectifier family. Intracellularly, Gαq signaling and calcium ions seem to be mandatory for the observed current and increased neuronal excitability.
description: Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Spin-vibronics in interacting nonmagnetic molecular nanojunctions
Creators: name: Weiss, S.
name: Brüggemann, J.
name: Thorwart, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We show that in the presence of ferromagnetic electronic reservoirs and spin-dependent tunnel couplings, molecular vibrations in nonmagnetic single molecular transistors induce an effective intramolecular exchange magnetic field. It generates a finite spin-accumulation and -precession for the electrons confined on the molecular bridge and occurs under (non)equilibrium conditions. The effective exchange magnetic field is calculated here to lowest order in the tunnel coupling for a nonequilibrium transport setup. Coulomb interaction between electrons is taken into account as well as a finite electron-phonon coupling. We show that for realistic physical parameters, an effective spin-phonon coupling emerges. It is induced by quantum many-body interactions, which are either electron-phonon or Coulomb-like. We investigate the precession and accumulation of the confined spins as function of bias- and gate-voltages as well as their dependence on the angle enclosed by the magnetizations between the left and right reservoir.
description: replaced with published version
Functional Oligomeric State of Avian Sarcoma Virus Integrase
Creators: name: Erie, Dorothy A.
name: Wong, Isaac
name: Bao, Kogan K.
name: Miller, Jamie K.
name: Wang, Hong
name: Skalka, Anna Marie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Retroviral integrase, one of only three enzymes encoded by the virus, catalyzes the essential step of inserting a DNA copy of the viral genome into the host during infection. Using the avian sarcoma virus integrase, we demonstrate that the enzyme functions as a tetramer. In presteady-state active site titrations, four integrase protomers were required for a single catalytic turnover. Volumetric determination of integrase-DNA complexes imaged by atomic force microscopy during the initial turnover additionally revealed substrate-induced assembly of a tetramer. These results suggest that tetramer formation may be a requisite step during catalysis with ramifications for antiviral design strategies targeting the structurally homologous human immunodeficiency virus, type 1 (HIV-1) integrase.
Supplementary figures, tables and datasets from Bracketing phenogenotypic limits of mammalian hybridization.
Creators: name: Savriama, Yoland
name: Valtonen, Mia
name: Kammonen, Juhana
name: Rastas, Pasi
name: Olli-Pekka Smolander
name: Lyyski, Annina
name: Häkkinen, Teemu J.
name: Corfe, Ian J.
name: Gerber, Sylvain
name: Salazar-Ciudad, Isaac
name: Paulin, Lars
name: Holm, Liisa
name: Löytynoja, Ari
name: Auvinen, Petri
name: Jernvall, Jukka
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Developmental Biology
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences

description: Suplementary figures S1-S6, tables S1-S12 and datasets S1 and S2
Hairpin Formation in Friedreich's Ataxia Triplet Repeat Expansion
Creators: name: Topal, Michael D.
name: Makhov, Alexander M.
name: Heidenfelder, Brooke L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Triplet repeat tracts occur throughout the human genome. Expansions of a (GAA)(n)/(TTC)(n) repeat tract during its transmission from parent to child are tightly associated with the occurrence of Friedreich's ataxia. Evidence supports DNA slippage during DNA replication as the cause of the expansions. DNA slippage results in single-stranded expansion intermediates. Evidence has accumulated that predicts that hairpin structures protect from DNA repair the expansion intermediates of all of the disease-associated repeats except for those of Friedreich's ataxia. How the latter repeat expansions avoid repair remains a mystery because (GAA)(n) and (TTC)(n) repeats are reported not to self-anneal. To characterize the Friedreich's ataxia intermediates, we generated massive expansions of (GAA)(n) and (TTC)(n) during DNA replication in vitro using human polymerase beta and the Klenow fragment of Escherichia coli polymerase I. Electron microscopy, endonuclease cleavage, and DNA sequencing of the expansion products demonstrate, for the first time, the occurrence of large and growing (GAA)(n) and (TTC)(n) hairpins during DNA synthesis. The results provide unifying evidence that predicts that hairpin formation during DNA synthesis mediates all of the disease-associated, triplet repeat expansions.
Geometry and supersymmetry of heterotic warped flux AdS backgrounds
Creators: name: Beck, S. W.
name: Gutowski, J. B.
name: Papadopoulos, G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We classify the geometries of the most general warped, flux AdS backgrounds of heterotic supergravity up to two loop order in sigma model perturbation theory. We show under some mild assumptions that there are no $AdS_n$ backgrounds with $n\not=3$. Moreover the warp factor of AdS$_3$ backgrounds is constant, the geometry is a product $AdS_3\times M^7$ and such solutions preserve, 2, 4, 6 and 8 supersymmetries. The geometry of $M^7$ has been specified in all cases. For 2 supersymmetries, it has been found that $M^7$ admits a suitably restricted $G_2$ structure. For 4 supersymmetries, $M^7$ has an $SU(3)$ structure and can be described locally as a circle fibration over a 6-dimensional KT manifold. For 6 and 8 supersymmetries, $M^7$ has an $SU(2)$ structure and can be described locally as a $S^3$ fibration over a 4-dimensional manifold which either has an anti-self dual Weyl tensor or a hyper-Kähler structure, respectively. We also demonstrate a new Lichnerowicz type theorem in the presence of $α'$ corrections.
description: 34 pages. Reference added
(1724) Florence Blackburn Condor
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(1721) John Crossley
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Heat Shock Suppresses the Permeability Transition in Rat Liver Mitochondria
Creators: name: Lemasters, John J.
name: He, Lihua
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Heat shock proteins inhibit apoptotic and necrotic cell death in various cell types. However, the specific mechanism underlying protection by heat shock proteins remains unclear. To test the hypothesis that heat shock proteins inhibit cell death by blocking opening of mitochondrial permeability transition (MPT) pores, mitochondria from heat-preconditioned rat livers were isolated by differential centrifugation. Heat shock inhibited MPT pore opening induced by 50 microm CaCl(2) plus 5 microm HgCl(2) or 1 microm mastoparan and by 200 microm CaCl(2) alone. Half-maximal swelling was delayed 15 min or more after heat shock compared with control. Heat shock also increased the threshold of unregulated (Ca(2+)-independent and cyclosporin A-insensitive) MPT pore opening induced by higher doses of HgCl(2) and mastoparan. Heat shock treatment decreased mitochondrial reactive oxygen species formation by 27% but did not change mitochondrial respiration, membrane potential, Ca(2+) uptake, or total glutathione in mitochondrial and cytosolic extracts of liver. Western blot analysis showed that mitochondrial Hsp25 increased, whereas Hsp10, Hsp60, Hsp70, Hsp75, cyclophilin D, and voltage-dependent anion channel did not change after heat shock. These results indicate that heat shock causes resistance to opening of MPT pores, which may contribute to heat shock protection against cellular injury.
Beating the amorphous limit in thermal conductivity by superlattices design
Creators: name: Mizuno, Hideyuki
name: Mossa, Stefano
name: Barrat, Jean-Louis
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: The value measured in the amorphous structure with the same chemical composition is often considered as a lower bound for the thermal conductivity of any material: the heat carriers are strongly scattered by disorder, and their lifetimes reach the minimum time scale of thermal vibrations. An appropriate design at the nano-scale, however, may allow one to reduce the thermal conductivity even below the amorphous limit. In the present contribution, using molecular-dynamics simulation and the Green-Kubo formulation, we study systematically the thermal conductivity of layered phononic materials (superlattices), by tuning different parameters that can characterize such structures. We discover that the key to reach a lower-than-amorphous thermal conductivity is to block almost completely the propagation of the heat carriers, the superlattice phonons. We demonstrate that a large mass difference in the two intercalated layers, or weakened interactions across the interface between layers result in materials with very low thermal conductivity, below the values of the corresponding amorphous counterparts.
Superlubric to stick-slip sliding of incommensurate graphene flakes on graphite
Creators: name: van Wijk, M. M.
name: Dienwiebel, M.
name: Frenken, J. W. M.
name: Fasolino, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We calculate the friction of fully mobile graphene flakes sliding on graphite. For incommensurately stacked flakes, we find a sudden and reversible increase in friction with load, in agreement with experimental observations. The transition from smooth sliding to stick-slip and the corresponding increase in friction is neither due to rotations to commensurate contact nor to dislocations but to a pinning caused by vertical distortions of edge atoms also when they are saturated by Hydrogen. This behavior should apply to all layered materials with strong in-plane bonding.
title: Issues in theatrical management: Howard and Wyndham and the evolution of the British touring circuit
Creators: name: Iles, Paul
Publisher: name: University of Glasgow
Year: 1997
Subjects: subject: Theatre history, arts management.

description: This study sets out to analyse and discuss a number of key issues in theatrical management within the boundaries of a larger narrative about the history of the Scottish company, Howard and Wyndham. It considers changing shifts in leadership and policy, from actor- managers to business managers, from stock company to the rise and fall of the touring circuit, tensions between the provincial theatre and London's West End, the ground between commerce and art, the relationship of a profit-making company to subsidised theatres and the separation of theatre buildings and theatre production. The study is divided into six chapters and a conclusion, with two appendices and bibliography. It covers a period from 1851 to 1977. Chapter One introduces the thesis by attempting to define the role of manager in the theatre in relationship to the artform, discusses the work of earlier and famous theatrical managers, observes the historiography of theatrical managers and their work, discussing books about theatre history in which the subject is treated, at best, superficially. Chapter Two examines the origins of the Howard and Wyndham organisation in the mid-nineteenth century, under the leadership of actor-managers at the Theatre Royal, Edinburgh. It scrutinises their artistically and commercially respected enterprise, managing theatres, producing plays with a resident company and building the foundations for expansion. Chapter Three observes the formal incorporation of the company, the rise of touring managers and their productions, further expansion in Scotland and England, its profitability and the transition from the founding Howard and Wyndham families to the Cruikshanks, another father and son partnership. Chapter Four describes the influence of business managers, the move of head office to London, expansion towards theatrical monopoly and the company's relationship to primary producers through an interlocking myriad of directorships with West End theatres. Chapter Five is an assessment of the company's detailed management operations, explaining how a sophisticated and profit oriented administration served its large chain of theatres. Chapter Six considers the decline of the company and weighs internal causes leading to its closure with external influences wrought by the ebb of touring theatre. The conclusion comments briefly on the Howard and Wyndham experience in its entirety, highlighting its striking characteristics and discussing its particular merits and shortcomings. Appendices comprise a glossary of terms used in theatre management and touring as well as an examination of key contracts.
Effects of large-scale non-axisymmetric perturbations in the mean-field solar dynamo
Creators: name: Pipin, V. V.
name: Kosovichev, A. G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We explore a response of a non-linear non-axisymmetric mean-field solar dynamo model to shallow non-axisymmetric perturbations. After a relaxation period the amplitude of the non-axisymmetric field depends on the initial condition, helicity conservation, and the depth of perturbation. It is found that a perturbation which is anchored at r=0.9R has a profound effect on the dynamo process, producing a transient magnetic cycle of the axisymmetric magnetic field, if it is initiated at the growing phase of the cycle. The non-symmetric with respect to the equator perturbation results in a hemispheric asymmetry of the magnetic activity. The evolution of the axisymmetric and non-axisymmetric field depends on the turbulent magnetic Reynolds number R_m. In the range of R_m=10^{4-6} the evolution returns to the normal course in the next cycle, in which the non-axisymmetric field is generated due to a non-linear alpha-effect and magnetic buoyancy. In the stationary state the large-scale magnetic field demonstrates a phenomenon of "active longitudes" with cyclic 180 degree "flip-flop" changes of the large-scale magnetic field orientation. The flip-flop effect is known from observations of solar and stellar magnetic cycles. However this effect disappears in the model which includes the meridional circulation pattern determined by helioseismology. The rotation rate of the non-axisymmetric field components varies during the relaxation period, and carries important information about the dynamo process.
description: 41 pages, 11 figures, revised version
Supplementary figures, tables and datasets from Bracketing phenogenotypic limits of mammalian hybridization
Creators: name: Savriama, Yoland
name: Valtonen, Mia
name: Kammonen, Juhana
name: Rastas, Pasi
name: Olli-Pekka Smolander
name: Lyyski, Annina
name: Häkkinen, Teemu J.
name: Corfe, Ian J.
name: Gerber, Sylvain
name: Salazar-Ciudad, Isaac
name: Paulin, Lars
name: Holm, Liisa
name: Löytynoja, Ari
name: Auvinen, Petri
name: Jernvall, Jukka
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Developmental Biology
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences

description: Suplementary figures S1-S6, tables S1-S12 and datasets S1 and S2
High Affinity for Farnesyltransferase and Alternative Prenylation Contribute Individually to K-Ras4B Resistance to Farnesyltransferase Inhibitors
Creators: name: Weinbaum, Carolyn A.
name: Chen, Zhui
name: Sakabe, Kaoru
name: Fiordalisi, James J.
name: Casey, Patrick J.
name: Johnson II, Ronald L.
name: Cox, Adrienne D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Farnesyltransferase inhibitors (FTIs) block Ras farnesylation, subcellular localization and activity, and inhibit the growth of Ras-transformed cells. Although FTIs are ineffective against K-Ras4B, the Ras isoform most commonly mutated in human cancers, they can inhibit the growth of tumors containing oncogenic K-Ras4B, implicating other farnesylated proteins or suggesting distinct functions for farnesylated and for geranylgeranylated K-Ras, which is generated when farnesyltransferase is inhibited. In addition to bypassing FTI blockade through geranylgeranylation, K-Ras4B resistance to FTIs may also result from its higher affinity for farnesyltransferase. Using chimeric Ras proteins containing all combinations of Ras background, CAAX motif, and K-Ras polybasic domain, we show that either a polybasic domain or an alternatively prenylated CAAX renders Ras prenylation, Ras-induced Elk-1 activation, and anchorage-independent cell growth FTI-resistant. The polybasic domain alone increases the affinity of Ras for farnesyltransferase, implying independent roles for each K-Ras4B sequence element in FTI resistance. Using microarray analysis and colony formation assays, we confirm that K-Ras function is independent of the identity of the prenyl group and, therefore, that FTI inhibition of K-Ras transformed cells is likely to be independent of K-Ras inhibition. Our results imply that relevant FTI targets will lack both polybasic and potentially geranylgeranylated methionine-CAAX motifs.
Modeling of protein-peptide interactions using the CABS-dock web server for binding site search and flexible docking
Creators: name: Blaszczyk, Maciej
name: Kurcinski, Mateusz
name: Kouza, Maksim
name: Wieteska, Lukasz
name: Debinski, Aleksander
name: Kolinski, Andrzej
name: Kmiecik, Sebastian
Publisher: name: arXiv
Year: 2015
Subjects: subject: Biomolecules (q-bio.BM)
subject: FOS: Biological sciences

description: Protein-peptide interactions play essential functional roles in living organisms and their structural characterization is a hot subject of current experimental and theoretical research. Computational modeling of the structure of protein-peptide interactions is usually divided into two stages: prediction of the binding site at a protein receptor surface, and then docking (and modeling) the peptide structure into the known binding site. This paper presents a comprehensive CABS-dock method for the simultaneous search of binding sites and flexible protein-peptide docking, available as a users friendly web server. We present example CABS-dock results obtained in the default CABS-dock mode and using its advanced options that enable the user to increase the range of flexibility for chosen receptor fragments or to exclude user-selected binding modes from docking search. Furthermore, we demonstrate a strategy to improve CABS-dock performance by assessing the quality of models with classical molecular dynamics. Finally, we discuss the promising extensions and applications of the CABS-dock method and provide a tutorial appendix for the convenient analysis and visualization of CABS-dock results. The CABS-dock web server is freely available at http://biocomp.chem.uw.edu.pl/CABSdock/
description: Published in Methods journal, available online 10 July 2015
Table S4 from Sex mosaics in the honeybee: how haplodiploidy makes possible the evolution of novel forms of reproduction in social Hymenoptera.
Creators: name: Aamidor, Sarah E.
name: Yagound, Boris
name: Ronai, Isobel
name: Oldroyd, Benjamin P.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Developmental Biology

description: mtDNA Alignment
Honokiol, a Small Molecular Weight Natural Product, Inhibits Angiogenesis in Vitro and Tumor Growth in Vivo
Creators: name: Waqas, Muhammad
name: Soff, Gerald
name: Dubiel, Wolfgang
name: Ushio-Fukai, Masuko
name: Frank, David A.
name: Govindarajan, Baskaran
name: Campbell, Paul M.
name: Arbiser, Jack L.
name: Der, Channing J.
name: Battle, Traci
name: Cerimele, Francesca
name: Murad, Emma
name: Ye, Keqiang
name: Bai, Xianhe
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Natural products comprise a major source of small molecular weight angiogenesis inhibitors. We have used the transformed endothelial cell line SVR as an effective screen of natural product extracts to isolate anti-angiogenesis and anti-tumor compounds. Aqueous extracts of Magnolia grandiflora exhibit potent activity in our SVR proliferation assays. We found that the small molecular weight compound honokiol is the active principle of magnolia extract. Honokiol exhibited potent anti-proliferative activity against SVR cells in vitro. In addition, honokiol demonstrated preferential inhibition of primary human endothelial cells compared with fibroblasts and this inhibition was antagonized by antibodies against TNF alpha-related apoptosis-inducing ligand. In vivo, honokiol was highly effective against angiosarcoma in nude mice. Our preclinical data suggests that honokiol is a systemically available and non-toxic inhibitor of angiogenesis and should be further evaluated as a potential chemotherapeutic agent.
Human Airway Ecto-adenylate Kinase: A MECHANISM TO PROPAGATE ATP SIGNALING ON AIRWAY SURFACES
Creators: name: Picher, Maryse
name: Boucher, Richard C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Mechanically induced ATP release from human airway epithelial cells regulates mucociliary clearance through cell surface nucleotide receptors. Ectoenzymes detected on these cells were recently shown to terminate ATP-mediated responses by sequential dephosphorylation of extracellular ATP into ADP, AMP, and adenosine. We now demonstrate that an ecto-adenylate kinase (ecto-AK) contributes to the metabolism of adenine nucleotides on human airway epithelial surfaces by the reversible reaction: ATP + AMP 2ADP. This phosphotransferase exhibited a bilateral distribution on polarized primary cultures of human bronchial epithelial cells with a 4-fold higher activity on the mucosal surface. Ecto-AK presented an absolute requirement for magnesium and adenine-based nucleotides. UMP, GMP, and CMP could not substitute for AMP as gamma-phosphate acceptor, and UDP could not replace ADP. Apparent K(m) and V(max) values were 23 +/- 5 microM and 1.1 +/- 0.1 nmol x min(-1) x cm(-2) for ATP and 43 +/- 6 microM and 0.5 +/- 0.1 nmol x min(-1) x cm(-2) for ADP. Ecto-AK accounted for 20% of [gamma-(32)P]ATP dephosphorylation, and the impermeant AK inhibitor, diadenosine pentaphosphate, reduced ADPase activity by more than 70% on both epithelial surfaces. Time course experiments on ATP metabolism demonstrated that ecto-AK significantly prolongs effective ATP and ADP concentrations on airway epithelial surfaces for P2 receptor signaling and reduces by 6-fold adenosine production. Our data suggest a role for this nucleotide entrapment cycle in the propagation of purine-mediated mucociliary clearance on human airway epithelial surfaces.
(1718) Edward Crossley
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Active and reactive power in stochastic resonance for energy harvesting
Creators: name: Kubota, Madoka
name: Takahashi, Ryo
name: Hikihara, Takashi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences

description: A power allocation to active and reactive power in stochastic resonance is discussed for energy harvesting from mechanical noise. It is confirmed that active power can be increased at stochastic resonance, in the same way of the relationship between energy and phase at an appropriate setting in resonance.
description: 3 pages, 4 figures
Comparing the Price Transmission Coefficients of the Domestic and Imported Agricultural Products: Based on a Cointegration Analysis
Creators: name: Jeon, Sanggon
name: Jeon, Sanggon
Publisher: name: Unknown
Year: 2009
Subjects: subject: Demand and Price Analysis
subject: International Relations/Trade
subject: cointegration
subject: price transmission
subject: unit root

description: This study estimates the degree of price transmission between domestic and imported agricultural products using monthly price time series data. To do that, this study tests unit root and conintegration between prices. The results of unit root tests show that many of each price time series data are understood as nonstationary. Therefore, we test whether there exists a cointegration relationship between prices. The results of the test indicate that domestic prices of different qualities in the same product and domestic and imported prices are cointegrated. In other words, there are long run equilibrium relations between these prices. Furthermore, we compare the degree of price transmission and find out that for many agricultural products the degree of price transmission of imported products to domestic products is smaller than that of price transmission between domestic prices, which may suggest that the shocks in the world market are partially transmitted to the domestic agricultural market.
Additional methodological information, figures and tables from The microbiome at the interface between environmental stress and animal health: an example from the most threatened vertebrate group
Creators: name: Eterovick, Paula C
name: Schmidt, Robin
name: Sabino-Pinto, Joana
name: Yang, Chen
name: KÃ¼nzel, Sven
name: Ruthsatz, Katharina
Publisher: name: The Royal Society
Year: 2024
Subjects: classificationCode: 310404
subject: Evolution of developmental systems

description: Information on animal husbandry, treatment implementation, CORT release and extraction, DNA sequence denoising and filtering, supplementary figures and tables.
On the migration of two planets in a disc and the formation of mean motion resonances
Creators: name: Migaszewski, Cezary
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We study the dynamics of a system of two super-Earths embedded in a protoplanetary disc. We build a simple model of an irradiated viscous disc and use analytical prescriptions for the planet-disc interactions which lead to migration. We show that depending on the disc parameters, planets' masses and their positions in the disc, the migration of each planet can be inward or outward and the migration of a two-planet system can be convergent (which may lead to formation of a first order mean motion resonance, MMR) or divergent (a system moves away from MMR). We performed $3500$ simulations of the migration of two-planet systems with various masses and initial orbits. Almost all of them end up as resonant configurations, although the period ratios may be very distant from the nominal values of a given MMR. We found that almost all the systems resulting from the migration are periodic configurations.
description: accepted to MNRAS, 12 pages, 10 figures
MLPerf Inference 3D-Unet OpenVINO Model on BraTS 2019 dataset (fold 1)
Creators: name: Po-Han Huang
name: Ribalta, Pablo
name: Karargyris, Alex
name: Isensee, Fabian
name: Reina, Tony
name: Khalique Ahmed
Publisher: name: Zenodo
Year: 2020

description: This 3D-Unet TensorFlow model is converted from https://zenodo.org/record/3928973. See MLPerf Inference GitHub repository for instructions about how to run this model. Link: https://github.com/mlperf/inference/tree/master/v0.7/medical_imaging/3d-unet
(1719) Joseph Crossley
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Schwartz operators
Creators: name: Keyl, Michael
name: Kiukas, Jukka
name: Werner, Reinhard F.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: Functional Analysis (math.FA)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: In this paper we introduce Schwartz operators as a non-commutative analog of Schwartz functions and provide a detailed discussion of their properties. We equip them in particular with a number of different (but equivalent) families of seminorms which turns the space of Schwartz operators into a Frechet space. The study of the topological dual leads to non-commutative tempered distributions which are discussed in detail as well. We show in particular that the latter can be identified with a certain class of quadratic forms, therefore making operations like products with bounded (and also some unbounded) operators and quantum harmonic analysis available to objects which are otherwise too singular for being a Hilbert space operator. Finally we show how the new methods can be applied by studying operator moment problems and convergence properties of fluctuation operators.
description: 49 pages, no figures