cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Assessment of Topoisomerase II α Status in Breast Cancer by Quantitative PCR, Gene Expression Microarrays, Immunohistochemistry, and Fluorescence in Situ Hybridization
Creators: name: Oliva, Belén
name: Arroyo Fernández, Manuel
name: Díaz Rubio, Eduardo
name: Cheang, Maggie C.U.
name: Perou, Charles M.
name: Romero, Atocha
name: He, Xiaping
name: Llopis, Trinidad Caldés
name: Martín, Miguel
name: López García-Asenjo, José Antonio
name: de la Hoya, Miguel
name: García Sáenz, Jose Ángel
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Anthracyclines are frequently used for the treatment of breast cancer and topoisomerase II alpha (TOP2A) is considered to be the molecular target. Numerous studies have evaluated the predictive value of TOP2A using different methodological approaches and inconsistent results have been reported. Indeed, the correlation between techniques for the assessment of TOP2A status has not been well evaluated. In this study, we determined TOP2A status in 61 breast tumor samples by real-time PCR, DNA microarrays, immunohistochemistry (IHC), and fluorescence in situ hybridization (FISH), and then evaluated these results with clinical-pathological features and breast cancer intrinsic subtypes. First, we observed a statistical significant correlation of TOP2A gene expression between real-time PCR and microarrays (Pearson coefficient, 0.816; P < 0.001), and both predicted TOP2A IHC results fairly well (area under the curve > 0.74). In contrast, poor agreement between FISH and IHC data was observed (k: 0.134). Secondly, TOP2A expression was found significantly associated with cell proliferation, and with the highly proliferative Luminal B, Her2-enriched and Basal-like intrinsic subtypes. In conclusion, TOP2A expression in breast cancer was associated with high proliferation and aggressive tumor subtypes and appears to be independent of its amplification status. All of these features should be taken into consideration when assessing the predictive value of TOP2A for anthracycline-based chemotherapy.
Reconstructing the star formation history of the Milky Way disc(s) from chemical abundances
Creators: name: Snaith, O.
name: Haywood, M.
name: Di Matteo, P.
name: Lehnert, M. D.
name: Combes, F.
name: Katz, D.
name: Gómez, A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We develop a chemical evolution model in order to study the star formation history of the Milky Way. Our model assumes that the Milky Way is formed from a closed box-like system in the inner regions, while the outer parts of the disc experience some accretion. Unlike the usual procedure, we do not fix the star formation prescription (e.g. Kennicutt law) in order to reproduce the chemical abundance trends. Instead, we fit the abundance trends with age in order to recover the star formation history of the Galaxy. Our method enables one to recover with unprecedented accuracy the star formation history of the Milky Way in the first Gyrs, in both the inner (R<7-8kpc) and outer (R>9-10kpc) discs as sampled in the solar vicinity. We show that, in the inner disc, half of the stellar mass formed during the thick disc phase, in the first 4-5 Gyr. This phase was followed by a significant dip in the star formation activity (at 8-9 Gyr) and a period of roughly constant lower level star formation for the remaining 8 Gyr. The thick disc phase has produced as many metals in 4 Gyr as the thin disc in the remaining 8 Gyr. Our results suggest that a closed box model is able to fit all the available constraints in the inner disc. A closed box system is qualitatively equivalent to a regime where the accretion rate, at high redshift, maintains a high gas fraction in the inner disc. In such conditions, the SFR is mainly governed by the high turbulence of the ISM. By z~1 it is possible that most of the accretion takes place in the outer disc, while the star formation activity in the inner disc is mostly sustained by the gas not consumed during the thick disc phase, and the continuous ejecta from earlier generations of stars. The outer disc follows a star formation history very similar to that of the inner disc, although initiated at z~2, about 2 Gyr before the onset of the thin disc formation in the inner disc.
description: 30 pages, 18 figures, 3 tables, accepted by A&A - minor stylistic changes
Highly-Efficient Binary Neural Networks for Visual Place Recognition
Creators: name: Ferrarini, Bruno
name: Milford, Michael
name: McDonald-Maier, Klaus D.
name: Ehsan, Shoaib
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: VPR is a fundamental task for autonomous navigation as it enables a robot to localize itself in the workspace when a known location is detected. Although accuracy is an essential requirement for a VPR technique, computational and energy efficiency are not less important for real-world applications. CNN-based techniques archive state-of-the-art VPR performance but are computationally intensive and energy demanding. Binary neural networks (BNN) have been recently proposed to address VPR efficiently. Although a typical BNN is an order of magnitude more efficient than a CNN, its processing time and energy usage can be further improved. In a typical BNN, the first convolution is not completely binarized for the sake of accuracy. Consequently, the first layer is the slowest network stage, requiring a large share of the entire computational effort. This paper presents a class of BNNs for VPR that combines depthwise separable factorization and binarization to replace the first convolutional layer to improve computational and energy efficiency. Our best model achieves state-of-the-art VPR performance while spending considerably less time and energy to process an image than a BNN using a non-binary convolution as a first stage.
description: 8 pages, 10 figures, 2 tables
Phosphatase and Tensin Homolog on Chromosome 10 Is Phosphorylated in Primary Effusion Lymphoma and Kaposi's Sarcoma
Creators: name: Roy, Debasmita
name: Dittmer, Dirk P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Primary effusion lymphoma (PEL) is a non-Hodgkin's B-cell lymphoma driven by Kaposi's sarcoma-associated herpesvirus. It is uniquely sensitive to mTOR, PI3K, and Akt inhibitors; however, the basis of this requirement for the mTOR pathway remains to be elucidated. The phosphatase and tensin homolog gene (PTEN) on chromosome 10 controls the first step in the phosphatidylinositol 3 kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) pathway and is genetically inactivated in many solid tumors. We find an absence of PTEN deletions, mutations, or protein mislocalization in PEL. However, we find consistent hyperphosphorylation at serine 380 of PTEN, which is an inactivating modification, in PEL cell lines and in tumor xenografts. We also evaluated a large tissue microarray of Kaposi's sarcoma biopsies and observed concordant high levels of phospho-PTEN, phospho-Akt, and phospho-S6 ribosomal protein. Reintroduction of PTEN into PEL inhibited colony formation in soft agar, verifying the functional dependence of PEL on PI3K signaling. This was also true for PEL cell lines that carried mutant p53 and for KS-like cell lines. Activating PTEN in these cancers may yield a new treatment strategy for PEL, KS, and similar PTEN wild-type lymphomas.
A 4-fold-symmetry hexagonal ruthenium for magnetic heterostructures exhibiting enhanced perpendicular magnetic anisotropy and tunnel magnetoresistance
Creators: name: Wen, Zhenchao
name: Sukegawa, Hiroaki
name: Furubayashi, Takao
name: Koo, Jungwoo
name: Inomata, Koichiro
name: Mitani, Seiji
name: Hadorn, Jason Paul
name: Ohkubo, Tadakatsu
name: Hono, Kazuhiro
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: An unusual crystallographic orientation of hexagonal Ru with a 4-fold symmetry emerging in epitaxial MgO/Ru/Co2FeAl/MgO heterostructures is reported, in which an approximately Ru(02-23) growth attributes to the lattice matching among MgO, Ru, and Co2FeAl. Perpendicular magnetic anisotropy of the Co2FeAl/MgO interface is substantially enhanced as compared with those with a Cr(001) layer. The MTJs incorporating this structure gave rise to the largest tunnel magnetoresistance for perpendicular MTJs using low damping Heusler alloys. The 4-fold-symmetry hexagonal Ru arises from an epitaxial growth with an unprecedentedly high crystal index, opening a unique pathway for the development of perpendicular anisotropy films of cubic and tetragonal ferromagnetic alloys.
description: Advanced Materials 2014
AG Empowerment - Vorstellung der AG auf der Dhd 2023
Creators: name: Probst, Nora
name: Lang, Sarah
name: Gerber, Anja
name: Gengnagel, Tessa
Publisher: name: Zenodo
Year: 2023
Subjects: DHd-AG
DHd-AG Empowerment
Datenfeminismus
Machtkritik
Data Bias
Postcolonial DH
Diversity
Intersectionality
Data Feminism

description: Die AG Empowerment der DHd stellt sich vor, erläutert ihr Selbstverständnis, berichtet von ihren Aktivitäten und lädt Interessierte ein, sich einzubringen.
description: {"references": ["Jacqueline Wernimont and Elizabeth Losh: Problems with white feminism. Intersectionality and digital humanities. In: C. Crompton, R. J. Lane, and R. Siemens (eds.): Doing Digital Humanities. Practice, Training, Research. London/NY 2016."]}
The Ubiquitin Ligase MuRF1 Protects Against Cardiac Ischemia/Reperfusion Injury by Its Proteasome-Dependent Degradation of Phospho-c-Jun
Creators: name: Li, Luge
name: Lockyer, Pamela
name: Fan, Yong-Na
name: Du, Jie
name: Willis, Monte S.
name: Liu, De-Pei
name: Patterson, Cam
name: Kang, Eunice Y.
name: Li, Hui-Hua
name: Zhang, Mei-Li
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Despite improvements in interventions of acute coronary syndromes, primary reperfusion therapies restoring blood flow to ischemic myocardium leads to the activation of signaling cascades that induce cardiomyocyte cell death. These signaling cascades, including the mitogen-activated protein kinase signaling pathways, activate cardiomyocyte death in response to both ischemia and reperfusion. We have previously identified muscle ring finger-1 (MuRF1) as a cardiac-specific protein that regulates cardiomyocyte mass through its ubiquitin ligase activity, acting to degrade sarcomeric proteins and inhibit transcription factors involved in cardiac hypertrophy signaling. To determine MuRF1's role in cardiac ischemia/reperfusion (I/R) injury, cardiomyocytes in culture and intact hearts were challenged with I/R injury in the presence and absence of MuRF1. We found that MuRF1 is cardioprotective, in part, by its ability to prevent cell death by inhibiting Jun N-terminal kinase (JNK) signaling. MuRF1 specifically targets JNK's proximal downstream target, activated phospho-c-Jun, for degradation by the proteasome, effectively inhibiting downstream signaling and the induction of cell death. MuRF1's inhibitory affects on JNK signaling through its ubiquitin proteasome-dependent degradation of activated c-Jun is the first description of a cardiac ubiquitin ligase inhibiting mitogen-activated protein kinase signaling. MuRF1's cardioprotection in I/R injury is attenuated in the presence of pharmacologic JNK inhibition in vivo, suggesting a prominent role of MuRF1's regulation of c-Jun in the intact heart.
Towards establishing the presence or absence of horizons in coalescing binaries of compact objects by using their gravitational wave signals
Creators: name: Mukherjee, Samanwaya
name: Datta, Sayak
name: Tiwari, Srishti
name: Phukon, Khun Sang
name: Bose, Sukanta
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The quest for distinguishing black holes (BH) from horizonless compact objects using gravitational wave (GW) signals from coalescing compact binaries can be helped by utilizing the phenomenon of tidal heating (TH), which leaves its imprint on binary waveforms through the horizon parameters. We investigate the effects of TH on GWs to probe the observability of the horizon parameters, mainly using Fisher matrix analysis to determine the errors and covariances between them. The horizon parameters are defined as $H_1$ and $H_2$ for the two binary components, with $H_{1,2} \in [0,1]$, and combined with the component masses and spins to form two new parameters, $H_{\rm eff5}$ and $H_{\rm eff8}$, to minimize their covariances in parameter estimation studies. In this work, we add the phase contribution due to TH in terms of $H_{\rm eff5}$ and $H_{\rm eff8}$ to a post-Newtonian waveform and examine the variation of their measurement errors with the binary's total mass, mass ratio, luminosity distance, and component spins. Since the Fisher matrix approach works well for high signal-to-noise ratio, we focus mainly on third-generation (3G) GW detectors Einstein Telescope and Cosmic Explorer and use LIGO and Virgo for comparison. We find that the region in the total binary mass where measurements of $H_{\rm eff5}$ and $H_{\rm eff8}$ are most precise are $\sim 20 - 30M_\odot$ for LIGO-Virgo and $\sim 50 - 80M_\odot$ for 3G detectors. Higher component spins allow more precise measurements of $H_{\rm eff5}$ and $H_{\rm eff8}$. For a binary situated at 200 Mpc with component masses $12M_\odot$ and $18M_\odot$, equal spins $χ_1=χ_2=0.8$, and $H_{\rm eff5}=0.6$, $H_{\rm eff8}=12$, the 1-$σ$ errors in these two parameters are $\sim 0.01$ and $\sim 0.04$, respectively, in 3G detectors. We substantiate our results from Fisher studies with a set of Bayesian simulations.
Incompressible active phases at an interface. I. Formulation and axisymmetric odd flows
Creators: name: Jia, Leroy L.
name: Irvine, William T. M.
name: Shelley, Michael J.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Mathematical Physics (math-ph)
subject: Classical Physics (physics.class-ph)
subject: FOS: Physical sciences

description: Inspired by the recent realization of a 2D chiral fluid as an active monolayer droplet moving atop a 3D Stokesian fluid, we formulate mathematically its free-boundary dynamics. The surface droplet is described as a general 2D linear, incompressible, and isotropic fluid, having a viscous shear stress, an active chiral driving stress, and a Hall stress allowed by the lack of time-reversal symmetry. The droplet interacts with itself through its driven internal mechanics and by driving flows in the underlying 3D Stokes phase. We pose the dynamics as the solution to a singular integral-differential equation, over the droplet surface, using the mapping from surface stress to surface velocity for the 3D Stokes equations. Specializing to the case of axisymmetric droplets, exact representations for the chiral surface flow are given in terms of solutions to a singular integral equation, solved using both analytical and numerical techniques. For a disc-shaped monolayer, we additionally employ a semi-analytical solution that hinges on an orthogonal basis of Bessel functions and allows for efficient computation of the monolayer velocity field, which ranges from a nearly solid-body rotation to a unidirectional edge current depending on the subphase depth and the Saffman-Delbruck length. Except in the near-wall limit, these solutions have divergent surface shear stresses at droplet boundaries, a signature of systems with codimension one domains embedded in a three-dimensional medium. We further investigate the effect of a Hall viscosity, which couples radial and transverse surface velocity components, on the dynamics of a closing cavity.
VEGF-Mediated STAT3 Activation Inhibits Retinal Vascularization by Down-Regulating Local Erythropoietin Expression
Creators: name: Byfield, Grace
name: Hartnett, M. Elizabeth
name: McCloskey, Manabu
name: Wang, Haibo
name: Smith, George Wesley
name: Jiang, Yanchao
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Avascular, hypoxic retina has been postulated to be a source of angiogenic factors that cause aberrant angiogenesis and intravitreal neovascularization (IVNV) in retinopathy of prematurity. Vascular endothelial growth factor (VEGF) is an important factor involved. However, VEGF is also required for normal retinal vascular development, which raises concerns about inhibiting its activity to treat IVNV in retinopathy of prematurity. Therefore, understanding the effects that VEGF has on other factors in the development of avascular retina is important to prevent aberrant angiogenesis and IVNV. Here, we show that STAT3 was activated by increased retinal VEGF in the rat 50/10 oxygen-induced retinopathy model. Phospho-STAT3 colocalized with glutamine synthetase-labeled Müller cells. Inhibition of STAT3 reduced avascular retina and increased retinal erythropoietin (Epo) expression. Epo administered exogenously also reduced avascular retina in the model. In an in vitro study, hypoxia-induced VEGF inhibited Epo gene expression by STAT3 activation in rat Müller cells. The mechanism by which activated STAT3 regulated Epo was by inhibition of Epo promoter activity. Together, these findings show that increased retinal VEGF contributes to avascular retina by regulating retinal Epo expression through Janus kinase/STAT signaling. Our results suggest that rescuing Epo expression in the retina before the development of IVNV may promote normal developmental angiogenesis and, therefore, reduce the stimulus for later pathologic IVNV.
Classifying sequences by the optimized dissimilarity space embedding approach: a case study on the solubility analysis of the E. coli proteome
Creators: name: Livi, Lorenzo
name: Rizzi, Antonello
name: Sadeghian, Alireza
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Artificial Intelligence (cs.AI)
subject: Biological Physics (physics.bio-ph)
subject: Biomolecules (q-bio.BM)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences
subject: FOS: Biological sciences
subject: I.5

description: We evaluate a version of the recently-proposed classification system named Optimized Dissimilarity Space Embedding (ODSE) that operates in the input space of sequences of generic objects. The ODSE system has been originally presented as a classification system for patterns represented as labeled graphs. However, since ODSE is founded on the dissimilarity space representation of the input data, the classifier can be easily adapted to any input domain where it is possible to define a meaningful dissimilarity measure. Here we demonstrate the effectiveness of the ODSE classifier for sequences by considering an application dealing with the recognition of the solubility degree of the Escherichia coli proteome. Solubility, or analogously aggregation propensity, is an important property of protein molecules, which is intimately related to the mechanisms underlying the chemico-physical process of folding. Each protein of our dataset is initially associated with a solubility degree and it is represented as a sequence of symbols, denoting the 20 amino acid residues. The herein obtained computational results, which we stress that have been achieved with no context-dependent tuning of the ODSE system, confirm the validity and generality of the ODSE-based approach for structured data classification.
description: 10 pages, 49 references
Children’s influence on consumption-related decisions in single-mother families: Research review and Agenda
Creators: name: Chaudhury, Sarita Ray
name: Hyman, Michael
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Although social scientists have identified diverse behavioral patterns among children from dissimilarly structured families, scholars have progressed little in relating modern family processes to consumption-related decisions. Based on gaps and limitations identified in a review of the existing consumer decision-making literature, this study examines how children influence family consumption decision-making in single-mother families and posits a conceptual framework that integrates normative resource exchange theory with existing consumer decision-making model theory. The implications for a better understanding of processes rather than prevalent outcome-oriented focus for future research purposes are also discussed.
Short Hairpin RNA-Mediated Knockdown of VEGFA in Müller Cells Reduces Intravitreal Neovascularization in a Rat Model of Retinopathy of Prematurity
Creators: name: Hammond, Scott
name: Yang, Zhihong
name: Culp, William D.
name: McCloskey, Manabu
name: Hartnett, M. Elizabeth
name: Wang, Haibo
name: Smith, George W.
name: Kafri, Tal
name: Jiang, Yanchao
name: Flannery, John
name: Greenberg, Kenneth
name: Geisen, Pete
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Vascular endothelial growth factor (VEGF) A is implicated in aberrant angiogenesis and intravitreous neovascularization (IVNV) in retinopathy of prematurity (ROP). However, VEGFA also regulates retinal vascular development and functions as a retinal neural survival factor. By using a relevant ROP model, the 50/10 oxygen-induced retinopathy (OIR) model, we previously found that broad inhibition of VEGFA bioactivity using a neutralizing antibody to rat VEGF significantly reduced IVNV area compared with control IgG but also significantly reduced body weight gain in the pups, suggesting an adverse effect. Therefore, we propose that knockdown of up-regulated VEGFA in cells that overexpress it under pathological conditions would reduce IVNV without affecting physiological retinal vascular development or overall pup growth. Herein, we determined first that the VEGFA mRNA signal was located within the inner nuclear layer corresponding to CRALBP-labeled Müller cells of pups in the 50/10 OIR model. We then developed a lentiviral-delivered miR-30–embedded shRNA against VEGFA that targeted Müller cells. Reduction of VEGFA by lentivector VEGFA-shRNA–targeting Müller cells efficiently reduced 50/10 OIR up-regulated VEGFA and IVNV in the model, without adversely affecting physiological retinal vascular development or pup weight gain. Knockdown of VEGFA in rat Müller cells by lentivector VEGFA-shRNA significantly reduced VEGFR2 phosphorylation in retinal vascular endothelial cells. Our results suggest that targeted knockdown of overexpressed VEGFA in Müller cells safely reduces IVNV in a relevant ROP model.
Higgs-Dilaton cosmology: Universality vs. criticality
Creators: name: Rubio, Javier
name: Shaposhnikov, Mikhail
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The Higgs-Dilaton model is able to produce an early inflationary expansion followed by a dark energy dominated era responsible for the late time acceleration of the Universe. At tree level, the model predicts a small tensor-to-scalar ratio ($0.0021\leq r \leq 0.0034$), a tiny negative running of the spectral tilt ($-0.00057 \leq dn_s/d\ln k \leq -0.00034$) and a nontrivial consistency relation between the spectral tilt of scalar perturbations and the dark energy equation of state, which turns out to be close to a cosmological constant ($0 \leq 1+w_{DE} \leq 0.014$). We reconsider the validity of these predictions in the vicinity of the critical value of the Higgs self-coupling giving rise to an inflection point in the inflationary potential. The value of the inflationary observables in this case strongly depends on the parameters of the model. The tensor-to-scalar ratio can be large [$r\sim {\cal O}(0.1)$] and notably exceed its tree-level value. If that happens, the running of the scalar tilt becomes positive and rather big [$dn_s/d\ln k \sim {\cal O}(0.01)$] and the equation-of-state parameter of dark energy can significantly differ from a cosmological constant [$1+w_{DE}\sim {\cal O}(0.1)$].
description: 5 pages, 3 figures, published version, added clarifications and references, corrected typos
Green's function multiple-scattering theory with a truncated basis set: An Augmented-KKR formalism
Creators: name: Alam, Aftab
name: Khan, Suffian N.
name: Smirnov, Andrei
name: Nicholson, D. M.
name: Johnson, Duane D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Korringa-Kohn-Rostoker (KKR) Green's function, multiple-scattering theory is an efficient site-centered, electronic-structure technique for addressing an assembly of $N$ scatterers. Wave-functions are expanded in a spherical-wave basis on each scattering center and indexed up to a maximum orbital and azimuthal number $L_{max}=(l,m)_{max}$, while scattering matrices, which determine spectral properties, are truncated at $L_{tr}=(l,m)_{tr}$ where phase shifts $δ_{l>l_{tr}}$ are negligible. Historically, $L_{max}$ is set equal to $L_{tr}$; however, a more proper procedure retains free-electron and single-site contributions for $L_{max}>L_{tr}$ with $δ_{l>l_{tr}}$ set to zero [Zhang and Butler, Phys. Rev. B {\bf 46}, 7433]. We present a numerically efficient and accurate \emph{augmented}-KKR Green's function formalism that solves the KKR secular equations by matrix inversion [$\mathcal{R}^3$ process with rank $N(l_{tr}+1)^2$] and includes higher-order $L$ contributions via linear algebra [$\mathcal{R}^2$ process with rank $N(l_{max}+1)^2$]. Augmented-KKR yields properly normalized wave-functions, numerically cheaper basis-set convergence, and a total charge density and electron count that agrees with Lloyd's formula. For fcc Cu, bcc Fe and L$1_0$ CoPt, we present the formalism and numerical results for accuracy and for the convergence of the total energies, Fermi energies, and magnetic moments versus $L_{max}$ for a given $L_{tr}$.
description: 7 pages, 5 figures
Accuracy of dual-Doppler lidar retrievals of near-shore winds
Creators: name: Vasiljevic, Nikola
name: Courtney, Michael
Publisher: name: Zenodo
Year: 2017
Subjects: wind lidar
uncertainty
dual-Doppler uncertainty

description: In this presentation the accuracy in retrieving horizontal wind speed and wind direction using a dual-Doppler lidar system will be described. First, the line of sight wind speed uncertainty is described followed by the detailed description of the various sources of errors in laser beam pointing with a particular focus on static errors. A methodology for assessing static pointing errors is presented accompanied with results from the method implementation. Afterwards, mathematical relations for the horizontal wind speed and wind direction uncertainties are derived. For the end, the derived mathematical relations are implemented for the uncertainty assessment of the dual-Doppler retrievals of near-shore winds that took place during the RUNE experiment.
High fidelity state preparation and measurement of ion hyperfine qubits with I > 1/2
Creators: name: An, Fangzhao Alex
name: Ransford, Anthony
name: Schaffer, Andrew
name: Sletten, Lucas R.
name: Gaebler, John
name: Hostetter, James
name: Vittorini, Grahame
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present a method for achieving high fidelity state preparation and measurement (SPAM) using trapped ion hyperfine qubits with nuclear spins higher than $I = 1/2$. The ground states of these higher nuclear spin isotopes do not afford a simple frequency-selective state preparation scheme. We circumvent this limitation by stroboscopically driving strong and weak transitions, blending fast optical pumping using dipole transitions and narrow microwave or optical quadrupole transitions. We demonstrate this method with the $I=3/2$ isotope $^{137}\mbox{Ba}^+$ to achieve a SPAM infidelity of $\left(9.0 \pm 1.3\right) \times 10^{-5}$ ($-40.5 \pm 0.6$ dB), facilitating the use of a wider range of ion isotopes with favorable wavelengths and masses for quantum computation.
description: 5 pages, 4 figures
α(1,3)-Fucosyltransferases FUT4 and FUT7 Control Murine Susceptibility to Thrombosis
Creators: name: Bodary, Peter
name: Homeister, Jonathon W.
name: Mackey, Lantz C.
name: Rose, Jason
name: Eitzman, Daniel
name: Morales-Levy, Maria
name: Wang, Huili
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The α(1,3)-fucosyltransferases, types IV and VII (FUT4 and FUT7, respectively), are required for the synthesis of functional selectin-type leukocyte adhesion molecule ligands. The selectins and their ligands modulate leukocyte trafficking, and P-selectin and its ligand, P-selectin glycoprotein ligand-1, can modulate hemostasis and thrombosis. Regulation of thrombosis by FUT4 and/or FUT7 activity was examined in mouse models of carotid artery thrombosis and collagen/epinephrine-induced thromboembolism. Mice lacking both FUT4 and FUT7 (Fut−/− mice) had a shorter time to occlusive thrombus formation in the injured carotid artery and a higher mortality due to collagen/epinephrine-induced pulmonary thromboemboli. Mice lacking P-selectin or P-selectin glycoprotein ligand-1 did not have a prothrombotic phenotype. Whole blood platelet aggregation was enhanced, and plasma fibrinogen content, clot weight, and clot strength were increased in Fut−/− mice, and in vitro clot lysis was reduced compared with wild type. Fut4−/−, but not Fut7−/−, mice had increased pulmonary thromboembolism-induced mortality and decreased thromboemboli dissolution in vivo. These data show that FUT4 and FUT7 activity regulates thrombosis in a P-selectin– and P-selectin glycoprotein ligand-1–independent manner and suggest that FUT4 activity is important for thrombolysis.
py-irt: A Scalable Item Response Theory Library for Python
Creators: name: Lalor, John P.
name: Rodriguez, Pedro
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences

description: py-irt is a Python library for fitting Bayesian Item Response Theory (IRT) models. py-irt estimates latent traits of subjects and items, making it appropriate for use in IRT tasks as well as ideal-point models. py-irt is built on top of the Pyro and PyTorch frameworks and uses GPU-accelerated training to scale to large data sets. Code, documentation, and examples can be found at https://github.com/nd-ball/py-irt. py-irt can be installed from the GitHub page or the Python Package Index (PyPI).
MUSE integral-field spectroscopy towards the Frontier Fields Cluster Abell S1063: I. Data products and redshift identifications
Creators: name: Karman, W.
name: Caputi, K. I.
name: Grillo, C.
name: Balestra, I.
name: Rosati, P.
name: Vanzella, E.
name: Coe, D.
name: Christensen, L.
name: Koekemoer, A. M.
name: Kruehler, T.
name: Lombardi, M.
name: Mercurio, A.
name: Nonino, M.
name: van der Wel, A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present the first observations of the Frontier Fields Cluster Abell S1063 taken with the newly commissioned Multi Unit Spectroscopic Explorer (MUSE) integral field spectrograph. Because of the relatively large field of view (1 arcmin^2), MUSE is ideal to simultaneously target multiple galaxies in blank and cluster fields over the full optical spectrum. We analysed the four hours of data obtained in the Science Verification phase on this cluster and measured redshifts for 53 galaxies. We confirm the redshift of five cluster galaxies, and determine the redshift of 29 other cluster members. Behind the cluster, we find 17 galaxies at higher redshift, including three previously unknown Lyman-alpha emitters at z>3, and five multiply-lensed galaxies. We report the detection of a new z=4.113 multiply lensed galaxy, with images that are consistent with lensing model predictions derived for the Frontier Fields. We detect C III], C IV, and He II emission in a multiply lensed galaxy at z=3.116, suggesting the likely presence of an active galactic nucleus. We also created narrow-band images from the MUSE datacube to automatically search for additional line emitters corresponding to high-redshift candidates, but we could not identify any significant detections other than those found by visual inspection. With the new redshifts, it will become possible to obtain an accurate mass reconstruction in the core of Abell S1063 through refined strong lensing modelling. Overall, our results illustrate the breadth of scientific topics that can be addressed with a single MUSE pointing. We conclude that MUSE is a very efficient instrument to observe galaxy clusters, enabling their mass modelling, and to perform a blind search for high-redshift galaxies.
description: 11 pages, 10 figures, accepted for publication in A&A
Quantum Extremal Surfaces: Holographic Entanglement Entropy beyond the Classical Regime
Creators: name: Engelhardt, Netta
name: Wall, Aron C.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We propose that holographic entanglement entropy can be calculated at arbitrary orders in the bulk Planck constant using the concept of a "quantum extremal surface": a surface which extremizes the generalized entropy, i.e. the sum of area and bulk entanglement entropy. At leading order in bulk quantum corrections, our proposal agrees with the formula of Faulkner, Lewkowycz, and Maldacena, which was derived only at this order; beyond leading order corrections, the two conjectures diverge. Quantum extremal surfaces lie outside the causal domain of influence of the boundary region as well as its complement, and in some spacetimes there are barriers preventing them from entering certain regions. We comment on the implications for bulk reconstruction.
description: 28 pages, 6 figures. Version 3: typos fixed, minor changes to references
Rap1 GTPase Inhibits Tumor Necrosis Factor-α–Induced Choroidal Endothelial Migration via NADPH Oxidase– and NF-κB–Dependent Activation of Rac1
Creators: name: Wittchen, Erika S.
name: Wang, Haibo
name: Hartnett, M. Elizabeth
name: Fotheringham, Lori
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Macrophage-derived tumor necrosis factor (TNF)-α has been found in choroidal neovascularization (CNV) surgically removed from patients with age-related macular degeneration. However, the role of TNF-α in CNV development remains unclear. In a murine laser-induced CNV model, compared with un-lasered controls, TNF-α mRNA was increased in retinal pigment epithelial and choroidal tissue, and TNF-α colocalized with lectin-stained migrating choroidal endothelial cells (CECs). Inhibition of TNF-α with a neutralizing antibody reduced CNV volume and reactive oxygen species (ROS) level around CNV. In CECs, pretreatment with the antioxidant apocynin or knockdown of p22phox, a subunit of NADPH oxidase, inhibited TNF-α–induced ROS generation. Apocynin reduced TNF-α–induced NF-κB and Rac1 activation, and inhibited TNF-α–induced CEC migration. TNF-α–induced Rac1 activation and CEC migration were inhibited by NF-κB inhibitor Bay11-7082. Overexpression of Rap1a prevented TNF-α–induced ROS generation and reduced NF-κB and Rac1 activation. Activation of Rap1 by 8-(4-chlorophenylthio)adenosine-2′-O-Me-cAMP prevented TNF-α–induced CEC migration and reduced laser-induced CNV volume, ROS generation, and activation of NF-κB and Rac1. These findings provide evidence that active Rap1a inhibits TNF-α–induced CEC migration by inhibiting NADPH oxidase-dependent NF-κB and Rac1 activation and suggests that Rap1a de-escalates CNV development by interfering with ROS-dependent signaling in several steps of the pathogenic process.
pylspack: Parallel algorithms and data structures for sketching, column subset selection, regression and leverage scores
Creators: name: Sobczyk, Aleksandros
name: Gallopoulos, Efstratios
Publisher: name: arXiv
Year: 2022
Subjects: subject: Data Structures and Algorithms (cs.DS)
subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: Mathematical Software (cs.MS)
subject: FOS: Computer and information sciences
subject: F.2.1; G.3; E.1
subject: 65F50, 65F08, 65F20, 68W10, 68W20, 68P05

description: We present parallel algorithms and data structures for three fundamental operations in Numerical Linear Algebra: (i) Gaussian and CountSketch random projections and their combination, (ii) computation of the Gram matrix and (iii) computation of the squared row norms of the product of two matrices, with a special focus on "tall-and-skinny" matrices, which arise in many applications. We provide a detailed analysis of the ubiquitous CountSketch transform and its combination with Gaussian random projections, accounting for memory requirements, computational complexity and workload balancing. We also demonstrate how these results can be applied to column subset selection, least squares regression and leverage scores computation. These tools have been implemented in pylspack, a publicly available Python package (https://github.com/IBM/pylspack) whose core is written in C++ and parallelized with OpenMP, and which is compatible with standard matrix data structures of SciPy and NumPy. Extensive numerical experiments indicate that the proposed algorithms scale well and significantly outperform existing libraries for tall-and-skinny matrices.
description: To appear in ACM TOMS
Correlation effects in the tetragonal and collapsed tetragonal phase of CaFe2As2
Creators: name: Diehl, Jean
name: Backes, Steffen
name: Guterding, Daniel
name: Jeschke, Harald O.
name: Valenti, Roser
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We investigate the role of correlations in the tetragonal and collapsed tetragonal phases of CaFe2As2 by performing charge self-consistent DFT+DMFT (density functional theory combined with dynamical mean-field theory) calculations. While the topology of the Fermi surface is basically unaffected by the inclusion of correlation effects, we find important orbital-dependent mass renormalizations which show good agreement with recent angle-resolved photoemission (ARPES) experiments. Moreover, we observe a markedly different behavior of these quantities between the low-pressure tetragonal and the high-pressure collapsed tetragonal phase. We attribute these effects to the increased hybridization between the iron- and arsenic orbitals as one enters the collapsed tetragonal phase.
description: 6 pages, 6 figures
Basic Elements for Simulations of Standard Model Physics with Quantum Annealers: Multigrid and Clock States
Creators: name: Illa, Marc
name: Savage, Martin J.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We explore the potential of D-Wave's quantum annealers for computing some of the basic components required for quantum simulations of Standard Model physics. By implementing a basic multigrid (including "zooming") and specializing Feynman-clock algorithms, D-Wave's Advantage is used to study harmonic and anharmonic oscillators relevant for lattice scalar field theories and effective field theories, the time evolution of a single plaquette of SU(3) Yang-Mills lattice gauge field theory, and the dynamics of flavor entanglement in four neutrino systems.
description: 27 pages + Supplemental Material, 13 figures, 11 tables; improved Section III B; Published version
Recent Results on the Higgs Boson Properties in the $H\to ZZ \to 4\ell$ decay channel at CMS
Creators: name: Finco, Linda
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The latest results on the measurement of the properties of the new boson with mass around 125 GeV are reported. The analysis uses pp collision data recorded by the CMS detector at the LHC, corresponding to integrated luminosities of 5.1 $fb^{-1}$ at $\sqrt{s}$ = 7 TeV and 19.6 $fb^{-1}$ at $\sqrt{s}$ = 8 TeV. The boson is observed in the $H \to ZZ \to 4\ell$ channel ($\ell = e, μ$) and its mass is measured, giving the most precise result ever achieved. Moreover, the first experimental constraint on Higgs total width using $H \to ZZ \to 4\ell$ events is presented, setting an upper limit of 33 MeV at 95\% confidence level (42 MeV expected). The spin-parity of the boson is studied and the pure scalar hypothesis is found to be consistent with the observation, when compared to the other spin-parity hypotheses. No other significant Standard Model Higgs-like excess is found in the search and upper limits at 95\% condence level exclude the range 129.5 -832.0 GeV.
Collective excitations in jammed states: ultrafast defect propagation and finite-size scaling
Creators: name: Antonov, Alexander P.
name: Voráč, David
name: Ryabov, Artem
name: Maass, Philipp
Publisher: name: arXiv
Year: 2022
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: In crowded systems, particle currents can be mediated by propagating collective excitations which are generated as rare events, are localized and have a finite lifetime. The theoretical description of such excitations is hampered by the problem of identifying complex many-particle transition states, calculation of their free energies, and the evaluation of propagation mechanisms and velocities. Here we show that these problems can be tackled for a highly jammed system of hard spheres in a periodic potential. We derive generation rates of collective excitations, their anomalously high velocities, explain the occurrence of an apparent jamming transition and its strong dependence on the system size. The particle currents follow a scaling behavior, where for small systems the current is proportional to the generation rate and for large systems given by the geometric mean of the generation rate and velocity. Our theoretical approach is widely applicable to dense nonequilibrium systems in confined geometries. It provides new perspectives for studying dynamics of collective excitations in experiments.
description: 23 pages, 9 figures
"Among These Rocks": A Kierkegaardian Reading of T. S. Eliot's Poetic Personas 1915-27
Creators: name: Abbott, Robert
Publisher: name: Georgia State University
Year: 2023

description:
I attempt to draw out the existential-spiritual development of T. S. Eliots poetic personas from J. Alfred Prufrock to the Fisher King to the Hollow Men to, finally, the agd eagle with seaward flying / Unbroken wings of Ash Wednesday. I assess The Love Song of J. Alfred Prufrock, The Waste Land, The Hollow Men, and Ash Wednesday with the methodology of Sren Kierkegaards brand of existentialism, focusing especially on the individuals free will in reference to spirituality and religion. I apply Kierkegaards theory of the three stages of existence necessary for becoming a true self in interpreting these poems and their progressions. I pay special attention to the themes of existential anxiety (angst) and despair in these works, and how retrospectively they productively propel Eliot toward the successively higher stages of existence, and in turn, more developed poetic personas, culminating in Ash Wednesday and even Four Quartets.
Werewolf Identity in Cormac McCarthys Child of God
Creators: name: Acuna, Elias
Publisher: name: Georgia State University
Year: 2023

description:
Lester Ballards character in Child of God is one example of a socially marginalized outcast who figures prominently in Southern Gothic literature. Furthermore, he is ostracized from a homogenous community and propagates terror in its outskirts. Ballards disturbingly quotidian life allows for a werewolf motif to emerge, echoing the werewolf mythos of ancient Greek and Medieval tales. Placing Ballards violent delights within the context of werewolf studies illuminates a series of questions concerning identity, existentialism, and alterity in a text devoid of the supernatural. This thesis contends that the texts lycanthropic links manifest not through traditional werewolf conventions but as an effect of revestimiento near the climax of the plot, allowing Ballard to assume (an)other body. Deconstructionist and existentialist approaches towards the text make Lester Ballards werewolf subjectivity a unique ground for discussing the broader issues of identity, monstrosity, and alterity in the context of monster studies.
Powder Bed Fusion Processes for Metal Additive Manufacturing A review.docx
Creators: name: Khan, Rehbar
name: Rasool, Inayat
Publisher: name: figshare
Year: 2022
Subjects: Additive Manufacturing

description: In recent years, additive manufacturing has been in rapid progression. This review focuses on the research performed in metal additive manufacturing in recent years, particularly for powder bed fusion processes. Throughout this paper, we have discussed maximum metals with their properties required for such processes. Moreover, the parameters of each process such as temperature variation, laser /beam penetration etc. is discussed in detail elaborating all the necessary conditions. Furthermore, all the possible observed defects in MAM such as cracks, residual stresses, balling etc. are stated. In addition to this, methods are described to counter these defects. Also, the mechanical properties such as hardness, creep resistance, wear resistance etc. and most importantly PBF effects on metals is discussed. Moreover, the future implementations are also been stated in this paper thus opening the gateway for the readers for further research in MAM. All this discussion will allow the reader to get some maximum possible knowledge in this topic.
Recruitment Rhetoric of Metro Atlanta-Based Corporations
Creators: name: Moore, Cameron
Publisher: name: Georgia State University
Year: 2023

description:
This thesis, paired with the website Recruitment Rhetoric https://cmoore1240.wixsite.com/recruitment-rhetoric, seeks to analyze the ways in which selected metro Atlanta-based corporations utilize and construct recruitment rhetoric based on three theories: the rhetorical situation, mythos, and cultish. From this analysis, this paper then constructs a pedagogical strategy to teach recruitment rhetoric in freshman composition courses at Georgia State University to help undergraduate students develop a rhetorical literacy around corporate recruitment as they enter the workforce. Ultimately, this project aims to start a necessary conversation in the field that develops and interrogates recruitment rhetoric literacy practices.