cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Investigating the Mechanistic Role of the ATR Kinase on the Regulation of the INO80 Chromatin Remodeling Complex in Yeast
Creators: name: Shah, Saloni
name: Morrison, Ashby
Publisher: name: Stanford Digital Repository
Year: 2025
Subjects: subject: Cancer
subject: Yeast
subject: DNA damage
subject: ATR kinase
subject: Mec1
subject: INO80

description: Cancer is one of the leading causes of death worldwide, accounting for approximately 10 million deaths in 2020. To better understand cancer, we often look to simpler organisms that share many of the same fundamental biological processes. Yeast serves as an invaluable model organism due to its protein having high conservation with human protein and its great adaptability to outside stressors. This project aims to elucidate how yeast adapt to different nutrient environments. The study focuses on the interaction between Ataxia telangiectasia and Rad3 related (ATR) kinase — known for its crucial role in DNA damage response and metabolic homeostasis — and the INO80 chromatin remodeling complex, investigating ATR and INO80’s roles in cellular adaptation and metabolic regulation under environmental stressors. Since we are working with yeast, Mec1, a yeast homolog of human ATR kinase known for its crucial role in DNA damage response and metabolic homeostasis, will be studied for its regulatory influence on INO80. Through methodologies including yeast transformations and fitness assays across various media, the project seeks to uncover the mechanistic relationship between Mec1 and INO80. Our experiments showed that there are key experimental challenges in reducing Mec1 function in cells, but we did determine genetic interactions between Mec1 and Sml1 in cell viability and identified distinct roles for Rad9, Dun1, and Tel1 in regulating cellular stress adaptation. Understanding how yeast cells cope with stress can shine a light on similar processes in human cells. If we can identify these underlying mechanisms, we might pinpoint new targets for cancer treatments, ultimately helping to manage or even take steps towards preventing the disease.
Trading System Account Management
Creators: name: Yang, Alex
Publisher: name: Zenodo
Year: 2020
Subjects: trading system, risk management solution, user account management, user login

description: FinPricing is a FinTech company that provides a comprehensive front, middle and back office solution for capital market trading and risk management, asset and wealth management, and investment portfolio management. The software technology has been designed to meet the demands of market participants of all levels.
 The platform is very easy to install and simple to use. By taking away constraints whether it is through user friendly interfaces, broad asset class coverage, advanced analytics, improved access to data, flexible reporting, and extensible workflow or by offloading transactional or IT burdens we give you the freedom to define how you do business next.
description: https:////ia601402.us.archive.org/20/items/account-license-1/AccountLicense-1.pdf
Additional file 1 of Macrophage migration inhibitory factor facilitates the therapeutic efficacy of mesenchymal stem cells derived exosomes in acute myocardial infarction through upregulating miR-133a-3p
Creators: name: Zhu, Wenwu
name: Sun, Ling
name: Zhao, Pengcheng
name: Liu, Yaowu
name: Zhang, Jian
name: Zhang, Yuelin
name: Hong, Yimei
name: Zhu, Yeqian
name: Lu, Yao
name: Zhao, Wei
name: Chen, Xinguang
name: Zhang, Fengxiang
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Virology

description: Additional file 1. Additional figures and tables.
Funciones interactivas del enunciado
Creators: name: Valderrama Cárdenas, Juan Carlos
Publisher: name: Zenodo
Year: 2022
Subjects: Enunciado

description: Funciones interactivas del enunciado, planteamiento presentado por Bavelas, J., Gerwing, J., & Healing, S. (2017).
description: {"references": ["Bavelas, J., Gerwing, J., & Healing, S. (2017). Doing mutual understanding. Calibrating with micro-sequences in face-to-face dialogue. Journal of Pragmatics, 121, 91-112."]}
Table S2. Loadings of a phylogenetic PCA of squamate climatic niches. The first three principal components were selected based on the broken-stick criterion. from The evolution of climatic niches in squamate reptiles
Creators: name: Pie, Marcio R.
name: Campos, Leonardo L. F.
name: Meyer, Andreas L. S.
name: Andressa Duran
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology

description: Despite the remarkable diversity found in squamate reptiles, most of their species tend to be found in warm/dry environments, suggesting that climatic requirements played a crucial role in their diversification, yet little is known about the evolution of their climatic niches. In this study, we integrate climatic information associated with the geographical distribution of 1882 squamate species and their phylogenetic relationships to investigate the tempo and mode of climatic niche evolution in squamates, both over time and among lineages. We found that changes in climatic niche dynamics were pronounced over their recent squamate evolutionary history, and we identified extensive evidence for rate heterogeneity in squamate climatic niche evolution. Most rate shifts involved accelerations, particularly over the past 50 Myr. Most squamates occupy similar regions of the climatic niche space, with only a few lineages diversifying into colder and humid climatic conditions. The changes from arid to mesic conditions in some regions of the globe may have provided opportunities for climatic niche evolution, although most lineages tended to remain near their ancestral niche. Variation in rates of climatic niche evolution seems common, particularly in response to the availability of new climatic conditions over evolutionary time.
Detection accuracy from Distance-dependent pattern blending can camouflage salient aposematic signals
Creators: name: Barnett, James B.
name: Cuthill, Innes C.
name: Scott-Samuel, Nicholas E.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Detection experiment with human observers
Additional file 1 of Impact of HIV-1 CRF55_01B infection on the evolution of CD4 count and plasma HIV RNA load in men who have sex with men prior to antiretroviral therapy
Creators: name: Wei, Lan
name: Li, Hao
name: Lv, Xing
name: Zheng, Chenli
name: Li, Guilian
name: Yang, Zhengrong
name: Chen, Lin
name: Han, Xiaoxu
name: Zou, Huachun
name: Gao, Yanxiao
name: Cheng, Jinquan
name: Wang, Hui
name: Zhao, Jin
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 1: Table S1. Demographic characteristics of the 753 MSM with twice measurements of CD4 T-cell counts. Table S2. Demographic characteristics of the 216 MSM with twice measurements of HIV RNA viral load.
GELATIN HYDROXYAPPATITE 3D POROUS SCAFFOLD FOR REGENERATIVE DENTISTRY
Creators: name: Sabnam. B
name: Sangeetha S
name: Taniya M
name: M Sundaram K
Publisher: name: Zenodo
Year: 2024
Subjects: Three-Dimensional Printed Scaffolds, Alveolar Bone Regeneration, Hydroxyapatite, Calcium Phosphates, Biomaterials, Bone Tissue Engineering, Gelatin Scaffold, Regenerative Dentistry, Physiochemical Properties.

description: Abstract

Three-dimensional (3D) printed scaffolds have emerged as a promising alternative to traditional bone transplants for the regeneration of alveolar bone lesions. This scoping study aims to explore the effects of 3D-printed scaffolds utilizing hydroxyapatite (HA) and calcium phosphates on alveolar bone regeneration in animal models. Biomaterials such as hydroxyapatite and tricalcium phosphates have been extensively employed in the creation of these scaffolds. The study highlights the urgent need for scaffolds that combine high particle content and ductility for effective bone tissue engineering. To address this, a gradient 3D porous gelatin scaffold with hydroxyapatite is fabricated, with the ultimate goal of its application in regenerative dentistry. The physiochemical properties of the scaffold are also thoroughly characterized.
Preliminary Analyses
Creators: name: Kumar, Esha Rani
name: Mumby, Patricia
name: Schneider, Kristin
Publisher: name: OSF Registries
Year: 2021

description: All statistical analyses will be performed using Statistical Package for the Social Sciences (SPSS, Version 25.0) software. Time will be coded as 0, 1, 2, and 4 to reflect surveys given at baseline, three months post-transplant, six months post-transplant, and twelve months post-transplant to account for the unequal amount of time between timepoints. Preliminary analyses will be completed to identify any missing data or outliers.

The data will be evaluated for all assumptions related to the planned analyses including linear mixed models, Pearson r correlations, and Cox proportional hazard models. The following assumptions will be tested for linear mixed models. First, linearity will be tested by plotting the model residuals by the predictors (social support and treatment adherence). If the pattern in the plot is random, the assumption is met. However, if the pattern is non-random and follows a trend, predictors will be transformed. Next, homoscedasticity will be examined using scatter plots of the residual values. The assumption is met if the points are equally distributed linearly. QQ plots will test the assumption of normally distributed residuals in the model. The assumption is met if the residuals follow a linear pattern and do not deviate from the expected normal line. If the assumption is not met, log/ln transformations will be used to improve the normality of the data.

The data will be evaluated for a linear relationship between the social support and treatment adherence trajectories by plotting a scatterplot for the slopes of both trajectories. The assumption is met if there is a straight-line relationship between the two variables.

The proportional hazards assumption will be tested for Cox proportional hazard models. The proportional hazards assumption posits that the hazard ratio between two groups must remain constant over time and will be examined using Kaplan-Meier curves. If the curves cross, or the overall test of proportional hazards is significant, the proportional hazards assumption has been violated.

Gender and age may be included as possible covariates in all analyses, given that they may explain variations in social support, treatment adherence, and survival. To determine if gender or age should be included as a covariate, bivariate correlation analyses will be performed between both potential covariates, gender and age, and the outcome variables, social support, treatment adherence, and longevity. If the possible covariates are correlated with the dependent variables at a large Pearson correlation greater than .5, they will be included in all analyses as covariates. However, if the Pearson correlation is not large, covariates will not be included in analyses.
WissKI Unterstützungsangebot: SWOT-Analyse und Auswertung
Creators: name: Hastik, Canan
name: Fichtner, Mark
name: Schwenk, Gudrun Angelika
Publisher: name: Zenodo
Year: 2025
Subjects: Wissenschaftliche Kommunikationsinfrastruktur (WissKI)
Semantic Coworking Space (SCS)
WissKI Community of Practice
Tutorials
Dokumentation
Support

description: Folien zur SWOT-Analyse und Auswertung der bestehenden Unterstützungsangebote im Kontext von WissKI (Wissenschaftliche Kommunikationsinfrastruktur):

Dieser Foliensatz fasst die Ergebnisse einer SWOT-Analyse zusammen, die im Rahmen eines World Cafés auf dem WissKI-Anwender*innentreffen am 21.11.2024 in Nürnberg durchgeführt wurde. Vorbereitet und moderiert wurde die Session von Canan Hastik, die Auswertung erfolgte gemeinsam mit Mark Fichtner und Gudrun Schwenk. 

Im Mittelpunkt standen die von den Teilnehmenden eingebrachten Erfahrungen zu bestehenden Unterstützungsangeboten, deren Stärken und Schwächen sowie Chancen und Risiken in Bezug auf die Optimierung, Neuausrichtung und Pflege der WissKI-Dokumentationslandschaft. Ergänzend wurden Wünsche und Bedarfe an künftige Unterstützungsstrukturen und Best-Practice-Beispiele diskutiert.

Aus der Veranstaltung heraus gründete sich die TaskForce@WissKI Weekly mit dem Ziel, die WissKI-Dokumentation strukturiert und zielgruppenorientiert neu zu konzipieren.

This project with the funding code 16DKZ2016B (IGSD e.V.) and 16DKZ2016C (GNM) was funded by the Federal Ministry of Education and Research (BMBF) and NextGenerationEU (NGEU).
الصفة الرسمية والمحاكم الجنائية
Creators: name: TIJANI, MOHAMMED
Publisher: name: figshare
Year: 2022
Subjects: subject: 180116 International Law (excl. International Trade Law)
subject: FOS: Law

description: كان "غوستاف موني " من الأوائل الذين دعوا إلى إحداث محكمة جنائية دولية، لمحاكمة مجرمي الحرب على الأفعال التي يقترفونها أثناء الحرب، مهما كانت صفاتهم الرسمية. ثم عرفت مسألة الحصانة الجنائية تطورا ملحوظا، خاصة مع ظهور المحاكم الجنائية الدولية مثل محكمة نورمبرغ، وطوكيو، ويوغسلافيا السابقة، ورواندا، وقد وصل هذا التطور إلى أوجه مع ظهور المحكمة الجنائية الدولية الدائمة.
The US Algorithmic Accountability Act of 2022 vs. The EU Artificial Intelligence Act: What can they learn from each other?
Creators: name: Mokander, Jakob
name: Juneja, Prathm
name: Watson, David
name: Floridi, Luciano
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computers and Society (cs.CY)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: On the whole, the U.S. Algorithmic Accountability Act of 2022 (US AAA) is a pragmatic approach to balancing the benefits and risks of automated decision systems. Yet there is still room for improvement. This commentary highlights how the US AAA can both inform and learn from the European Artificial Intelligence Act (EU AIA).
description: Minds & Machines (2022)
Major ginsenoside contents in rhizomes of Panax sokpayensis and Panax bipinnatifidus
Creators: name: Bhusan Gurung
name: Bhardwaj, Pardeep Kumar
name: Rai, Amit Kumar
name: Dinabandhu Sahoo
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 60506 Virology

description: This study compared eight major ginsenosides (Rg1, Rg2, Rf, Re, Rd, Rc, Rb1 and Rb2) between Panax sokpayensis and Panax bipinnatifidus collected from Sikkim Himalaya, India. High-performance liquid chromatographic analysis revealed that all major ginsenosides were present in the rhizomes of P. sokpayensis except ginsenoside Rc, whereas ginsenoside Rf, Rc and Rb2 were not detected in P. bipinnatifidus.
Supporting Information from Locomotor performance of cane toads differs between native-range and invasive populations
Creators: name: Kosmala, Georgia
name: Christian, Keith
name: Brown, Gregory
name: Shine, Richard
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology

description: Invasive species provide a robust opportunity to evaluate how animals deal with novel environmental challenges. Shifts in locomotor performance—and thus the ability to disperse—(and especially, the degree to which it is constrained by thermal and hydric extremes) are of special importance, because they might affect the rate that an invader can spread. We studied cane toads (Rhinella marina) across a broad geographical range: two populations within the species' native range in Brazil, two invasive populations on the island of Hawai'i and eight invasive populations encompassing the eastern, western and southern limits of the toad invasion in Australia. A toad's locomotor performance on a circular raceway was strongly affected by both its temperature and its hydration state, but the nature and magnitude of those constraints differed across populations. In their native range, cane toads exhibited relatively low performance (even under optimal test conditions) and a rapid decrease in performance at lower temperatures and hydration levels. At the other extreme, performance was high in toads from southern Australia, and virtually unaffected by desiccation. Hawai'ian toads broadly resembled their Brazilian conspecifics, plausibly reflecting similar climatic conditions. The invasion of Australia has been accompanied by a dramatic enhancement in the toads' locomotor abilities, and (in some populations) by an ability to maintain locomotor performance even when the animal is cold and/or dehydrated. The geographical divergences in performance among cane toad populations graphically attest to the adaptability of invasive species in the face of novel abiotic challenges.
Biersma et al ESM from Global biogeographic patterns in bipolar moss species
Creators: name: E. M. Biersma
name: J. A. Jackson
name: J. Hyvönen
name: S. Koskinen
name: K. Linse
name: H. Griffiths
name: P. Convey
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 60302 Biogeography and Phylogeography

description: Contains list and map of sources of sampled material, maximum likelihood trees, dating methods and outcomes, mismatch distributions
title: saint Alexis
Creators: name: Centre De Recherches Historiques / Anthropologie Historique Du Long Moyen Âge
Publisher: name: EHESS (School for Advanced Studies in Social Sciences)
Year: 2019

description: Fils d'un patricien romain ; ascète oriental d'Édesse en Syrie au IVe siècle ; représenté en mendiant avec un bourdon de pèlerin ; attributs : un escalier, la lettre qu'il serre dans ses mains.
Electronic supplementary materials from Remotely sensed wind speed predicts soaring behaviour in a wide-ranging pelagic seabird
Creators: name: Gibb, Rory
name: Shoji, Akiko
name: Fayet, Annette L.
name: Perrins, Chris M.
name: Guilford, Tim
name: Freeman, Robin
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Environmental Science
subject: 110601 Biomechanics
subject: FOS: Health sciences
subject: Computational Biology

description: All supplementary figures and additional information
Rtn4-Supplementary data from microRNA-206 modulates an Rtn4a/Cxcr4a/Thbs3a axis in newly forming somite to maintain and stabilize the somite boundary formation of zebrafish embryos
Creators: name: Cheng-Yung Lin
name: He, Jun-Yu
name: Zeng, Chih-Wei
name: Moo-Rumg Loo
name: Wen-Yen Chang
name: Po-Hsiang Zhang
name: Huai-Jen Tsai
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Developmental Biology

description: Although microRNA-206 (miR-206) is known to regulate proliferation and differentiation of muscle fibroblasts, the role of miR-206 in early-stage somite development is still unknown. During somitogenesis of zebrafish embryos, reticulon4a (rtn4a) is specifically repressed by miR-206. Somite boundary was defective, and actin filaments were crossing over boundary in either miR-206-knockdown or rtn4a-overexpressed embryos. In these treated embryos, C–X–C motif chemokine receptor 4a (cxcr4a) was reduced, while thrombospondin 3a (thbs3a) was increased. The defective boundary was phenocopied in either cxcr4a-knockdown or thbs3a-overexpressed embryos. Repression of thbs3a expression by cxcr4a reduced the occurrence of boundary defect. We demonstrated that cxcr4a is an upstream regulator of thbs3a and that defective boundary cells could not process epithelialization in the absence of intracellular accumulation of the phosphorylated focal adhesion kinase (p-FAK) in boundary cells. Therefore, in the newly forming somites, miR-206-mediated downregulation of rtn4a increases cxcr4a. This activity largely decreases thbs3a expression in the epithelial cells of somite boundary, which causes epithelialization of boundary cells through mesenchymal–epithelial transition (MET) and eventually leads to somite boundary formation. Collectively, we suggest that miR-206 mediates novel pathway Rtn4a/Cxcr4a/Thbs3a axis that allows boundary cells to undergo MET and form somite boundaries in the newly forming somites of zebrafish embryos.
Contributos para a pedagogia social: neuroética. Educação vagarosa e ubuntu
Creators: name: Barbosa, Adérito Gomes
Publisher: name: Cadernos de Pedagogia Social
Year: 2012

description: A Pedagogia Social assenta na qualidade de intervenção socioeducativa, a qual procura suscitar a ação autoestruturante nos participantes, não só como agentes da resposta, mas fundamentalmente como agentes de propostas. É para esta base que apresentamos três apontamentos, três achegas importantes. Antes de mais agarrámo-nos à neuroética, a partir de Adela Cortina (2011). Ela apresenta a neuroética para averiguar em que medida as bases cerebrais predispõem a atuar, na relação com a autonomia, a justiça e a felicidade. A partir do nascimento, o ser humano tem uma grande margem de progressão na interação constante com o meio e com os demais seres humanos, cultivando não só a relação com os próximos, mas uma relação com os afastados, com os desconhecidos. O segundo ponto refere-se ao contributo da educação vagarosa, a partir de autores credenciados tais como Honoré (2005) e Francesh (2011). Estes autores alertam para fast education existente e abrem horizontes para uma slow education. Assim, apontam para a realidade de uma sociedade e de uma educação hoje em excesso de velocidade. Apresentam uma urgente proposta de uma educação vagarosa que não ultrapasse etapas e em que haja tempo e momentos sufi cientes (kairos) para que os conteúdos sejam assimilados. O terceiro apontamento circunscreve-se ao ubuntu como uma filosofia que existe em vários países de África que se centra no relacionamento das pessoas umas com as outras. É a humanidade para com os outros, colocando-os todos em interconetividade. Poderíamos definir o ubuntu da seguinte maneira: só posso ser tudo aquilo que sou se fizer tudo para que todos possam ser tudo aquilo que são. Estas três achegas querem atingir positivamente a cidadania e a solidariedade da humanidade, em tons pedagógicos.
description: Cadernos de Pedagogia Social, n. 4 (2012)
Additional file 1 of Variability in microplastic abundance, bisphenol A contamination, antioxidant properties, and health risks associated with vegetable consumption
Creators: name: Azeez, Luqmon
name: Adetoro, Rasheed O.
name: Agbaogun, Babatunde K.
name: Oyedeji, Abdulrasarq O.
name: Busari, Hassan K.
name: Oladejo, Abayomi A.
name: Oyelami, Oyeyinka K.
name: Deborah, Osilaja
name: Oladeji, Ruqoyyah D.
name: Basiru, Saheed
name: Muhammad-Lawal, Shakirat
name: Hammed, Aisha
name: Makanjuola, Abdulrahman O.
Publisher: name: figshare
Year: 2025
Subjects: subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Additional file 1.
Deliverable D3.1: Description of NI solutions and services exploiting zero-trust, exposure and compute continuum layers
Creators: name: Garcia-Saavedra, Andres
Publisher: name: Zenodo
Year: 2024
Subjects: network intelligence
Machine Learning
Artificial Intelligence
Radio Access Network
Anomaly Detection
5G/6G
Virtualization
Transport Network
Core Network
Security
Interoperability
Optimization
Resource Allocation
Global Operator Model
Compute Continuum Layer
Zero Trust Layer (ZTL)
Global Service Based Architecture

description: This document provides a comprehensive overview of network intelligence (NI) solutions for  enhancing mobile network security, efficiency, and reliability. It emphasizes the role of machine  learning, artificial intelligence, and advanced analytics in optimizing network operations. The report is structured around three key network domains: the Radio Access Network (RAN), the Transport Network, and the Core Network. In the RAN domain, solutions focus on data-driven task offloading for vRAN acceleration, hardware accelerator multiplexing, and ensuring interoperability between network components. For the Transport Network, the document proposes distributing machine  learning models across the user plane to reduce latency and improve scalability in traffic classification and anomaly detection. Regarding the Core Network, the focus is on optimizing breakout selection for global operators, introducing a limited trust analytics network for privacy-preserving network optimization, and developing anomaly detection mechanisms for global operations
title: tissu
Creators: name: Centre De Recherches Historiques / Anthropologie Historique Du Long Moyen Âge
Publisher: name: EHESS (School for Advanced Studies in Social Sciences)
Year: 2019

description: Terme d'emploi élargi, désignant tout tissu, qu'elle qu'en soit la matière,en particulier à la confection de draps, tentures, serviettes, torchons.
Unintended consequences: institutional artefacts, closure mechanisms and the performance gap
Creators: name: Boyd, Philippa
name: Schweber, Libby
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy

description: Renewable technologies often feature in policies to improve the energy efficiency of buildings. Designers introduce predicted energy values for specific technologies, but are surprised when the technologies fail to perform as expected. Three building projects are used to explore the effect of construction processes on the energy performance of building-integrated photovoltaic (BIPV) technology. In two cases BIPV failed to deliver expected energy generation, while in the third, dramatic changes in project processes and technical specifications were needed to achieve the specified output. A social construction of technology (SCOT) analysis documents how the energy generation of BIPV disappeared from view at certain points as actors focused on building features. A contribution is made to the theoretical development of SCOT by responding to two issues: privileging of cognitive closure mechanisms and the neglect of institutional analysis. The concept of inflection mechanisms is introduced as a second type of closure mechanism. More specifically, the role of institutional artefacts (e.g. planning requirements and schedules) in the construction process is found to contribute to the performance gap. To reduce the ‘performance gap’, practitioners need to focus on the distribution of design responsibility, sequencing of work and the location of expertise.
Additional file 1 of Deep learning-based predictive biomarker of pathological complete response to neoadjuvant chemotherapy from histological images in breast cancer
Creators: name: Li, Fengling
name: Yang, Yongquan
name: Wei, Yani
name: He, Ping
name: Chen, Jie
name: Zheng, Zhongxi
name: Bu, Hong
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences
subject: Virology

description: Additional file 1: Figure S1. The workflow of patient selection. Figure S2. Learning and inference processes of CNN I for TE identification. Figure S3. ROC curve and confusion matrices of CNN I for identifying TE. Figure S4. Learning and inference processes of CNN II for pCR prediction. Figure S5. ROC curves of CNN II for pCR prediction at tile-level. Figure S6. ROC curves of CNN II for pCR prediction based on TE on tile-level and WSI-level among subtypes in validation. Figure S7. Distributions of the pCR-score in the pCR group and the non-pCR group of the validation dataset. Table S1. Detailed NAC regimens of patients. Table S2. Demographic comparison between the primary and validation datasets. Table S3. Performance metrics of CNN I including accuracy, F1 score, AUC, sensitivity (recall), PPV (precision), specificity, and NPV. Table S4. Performance metrics including sensitivity (recall), PPV (precision), specificity, and NPV for biomarker-based models (T stage, nuclear grade, and Ki67).
Viral Footprints - Dialysis Unit - Day 4
Creators: name: Burns, Elizabeth
name: Matthews, Philippa
Publisher: name: figshare
Year: 2017
Subjects: subject: 60506 Virology
subject: FOS: Biological sciences

description: A creative day in a dialysis unit with inspiration from viruses and and the immune system to spark conversation, interest, learning and reflection.
Association of five-factor score with the mortality in Japanese patients with polyarteritis nodosa
Creators: name: Abe, Yoshiyuki
name: Kurisu Tada
name: Yamaji, Ken
name: Takasaki, Yoshinari
name: Tamura, Naoto
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Aim: To determine mortality and its predictive factors in Japanese patients with polyarteritis nodosa (PAN). Methods: This retrospective single-center study determined the mortality of 18 patients with PAN who were admitted to Juntendo University Hospital from 1994 to 2016. The variables at baseline, including patient demographics, clinical characteristics, and treatment, were analyzed for their association with mortality. Results: The median age of onset was 57.0 years. The 1-year survival rate was 100% (16/16) and the 5-year survival rate was 80.0% (8/10). The relationship between mortality, as defined by the survival rate and each variable was evaluated by Cox univariate analysis. A higher 2009 five-factor score (FFS) was associated with increased mortality, with a hazard ratio of 2.34 (p = .04). Analysis of the secondary outcome of relapse-free survival time revealed an association with rapid progressive renal failure, Birmingham Vasculitis Activity Score (BVAS), the 1996 FFS, and the 2009 FFS, with hazard ratios of 7.28 (p = .048), 1.26 (p = .02), 2.32 (p = .03), and 1.82 (p = .04), respectively. Conclusion: We investigated mortality, relapse-free survival, and their predictive factors in Japanese patients with PAN. The BVAS and the 1996 FFS at diagnosis may be prognostic factors for relapse-free survival, and the 2009 FFS at diagnosis may be a prognostic factor for both mortality and relapse-free survival.
Additional file 1 of HLA-F regulates the proliferation of trophoblast via PKM2-dependent glycolysis in the pathogenesis of preeclampsia
Creators: name: Xu, Ruiling
name: Huang, Yu
name: Xie, Wenchi
name: Luo, Dan
name: Mei, Jie
name: Liu, Xinghui
name: Liu, Fulin
name: Luo, Fangyuan
Publisher: name: figshare
Year: 2025
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Supplementary Material 1
Additional file 3: of Overexpression of OsAGO1b Induces Adaxially Rolled Leaves by Affecting Leaf Abaxial Sclerenchymatous Cell Development in Rice
Creators: name: Li, Youhan
name: Yang, Yiqi
name: Liu, Ye
name: Li, Dexia
name: Zhao, Yahuan
name: Li, Zhijie
name: Liu, Ying
name: Jiang, Dagang
name: Li, Jing
name: Zhou, Hai
name: Chen, Jianghua
name: Zhuang, Chuxiong
name: Liu, Zhenlan
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: Table S3. Information of plant AGO1 proteins used for phylogenetic analysis. (DOCX 12 kb)
A relação socioeducativa como prática de relação de dádiva
Creators: name: Veloso, Gastão Ribeiro Pereira
Publisher: name: Cadernos de Pedagogia Social
Year: 2012

description: A pedagogia social refl ete criticamente sobre a práxis socioeducativa enquanto ação intencional que procura promover a capacitação subjetiva e cívica das pessoas e estabelecer laços sociais. Este artigo analisa a relação socioeducativa na ótica da dádiva. Inicialmente, procura-se conceptualizar a noção de dádiva, explicitando a sua estrutura de gratuitidade e liberdade. De seguida, examina-se a forma como a dádiva, constituindo um operador privilegiado do laço social, estabelece a relação social. Finalmente, reflete-se sobre a relação socioeducativa como prática de relação de dádiva. Considerando a relação socioeducativa como uma experiência de educação, solidariedade e dádiva, procura-se esclarecer o alcance desta afirmação, explicitando-se a estreita ligação entre solidariedade e dádiva, no contexto da relação socioeducativa. A dádiva emerge, então, como uma noção com relevância no seio da pedagogia social.
description: Cadernos de Pedagogia Social, n. 4 (2012)
Optimum Filament Setup for Efficient Lr Evporation
Creators: name: Warbinek, Jessica
Publisher: name: Zenodo
Year: 2020
Subjects: Lawrencium ; Filament desorption; Laser spectroscopy; Resonance ionization; Atomic level scheme; Gas cell; Radiation detection; Heavy actinides

description: Milestone Report on MS21: Optimum Filament Setup for Efficient Lr Evaporation Technical report on filament test measurements to determine the optimum filament for a sufficient desorption of Lr in the RADRIS technique. This optimum filament will be used in the search for atomic levels in Lr at the GSI in Darmstadt.
Investigation of the adsorption properties and structures of porous materials for adsorptive removal of pollutants from water
Creators: name: ZAHRA ABBASI
Publisher: name: Monash University
Year: 2017
Subjects: subject: 90410 Water Treatment Processes
subject: FOS: Chemical engineering
subject: 100701 Environmental Nanotechnology
subject: FOS: Nanotechnology

description: Adsorption is a low cost and effective method for the removal of non-biodegradable and harmful pollutants from water which has been widely used in industry. Porous and nanoporous materials such as metal organic frameworks (MOFs) and fly ash wastes were used as adsorbents for the removal of pollutants from water. The study showed MOF adsorbent could be fabricated as beads for easy handling and recycling due to the very low buoyancy. Temperature of heat treatment had significant effect on adsorption property of MOF adsorbents. Moreover, abundant alkaline fly ash wastes could be used for neutralizing acidic mining wastewaters containing heavy metals.
Figure S1, Model description and Table S1 from Non-goal-directed recall of specific events in apes after long delays
Creators: name: Lewis, Amy
name: Call, Josep
name: Berntsen, Dorthe
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology

description: Figure depicting the hiding event (Figure S1) and full description of the statistical model with results (Table S1)
Nós entre nós
Creators: name: Carvalho, Maria João
name: Palmeirão, Cristina
Publisher: name: Cadernos de Pedagogia Social
Year: 2012

description: O presente artigo pretende refletir sobre a necessidade de um paradigma do cuidado ético, em especial para a pessoa idosa, perspetivando atitudes e práticas de Apoio Domiciliário. Compreender de que forma os serviços de apoio domiciliário atuam como garante da dignidade humana é o mote utilizado para identifi car os valores e as motivações subjacentes à ação de cuidar da pessoa idosa; aferir e compreender quem são as pessoas que cuidam da pessoa idosa; identificar e caracterizar competências requeridas pelos serviços de apoio domiciliário no âmbito da intervenção gerontológica; aferir sobre as principais linhas de orientação e aproximações à prática da Pedagogia Social; compreender e esclarecer o papel atribuído ao Educador Social nos serviços de apoio domiciliário. A necessidade (urgente) de um cuidado-cuidado que resgate e valorize o lugar da pessoa na sociedade alimentou o nosso desejo (e projeto) de melhor entender as motivações e os interesses que movem pessoas e instituições a cuidar de pessoas idosas. Este desafio, enquanto pessoa e profissional, incitou-nos a perspetivar o cuidado sob matriz humanista e a ir ao encontro de profi ssionais e instituições com quem partilhamos o âmbito de ação. Partilha, cooperação e solidariedade são máximas que a Pedagogia Social assume de forma especial para potenciar o (re)encontro entre gerações e, nessa filosofia, também nós, procuramos saber como podemos trabalhar de forma a mais dignificar a vida das pessoas que recorrem aos serviços de apoio domiciliário.
description: Cadernos de Pedagogia Social, n. 4 (2012)
Covariates and statistical models estimating nutritional condition and juvenile recruitment of North American porcupines from Nutritional state reveals complex consequences of risk in a wild predator–prey community
Creators: name: DeWitt, Philip D.
name: Schuler, Matthew S.
name: Visscher, Darcy R.
name: Thiel, Richard P.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Animal populations are regulated by the combined effects of top-down, bottom-up and abiotic processes. Ecologists have struggled to isolate these mechanisms because their effects on prey behaviour, nutrition, security and fitness are often interrelated. We monitored how forage, non-consumptive effects (NCEs), consumptive predation and climatic conditions influenced the demography and nutritional state of a wild prey population during predator recolonization. Combined measures of nutrition, survival and population growth reveal that predators imposed strong effects on the prey population through interacting non-consumptive and consumptive effects, and forage mechanisms. Predation was directly responsible for adult survival, while declining recruitment was attributed to predation risk-sensitive foraging, manifested in poor female nutrition and juvenile recruitment. Substituting nutritional state into the recruitment model through a shared term reveals that predation risk-sensitive foraging was nearly twice as influential as summer forage conditions. Our findings provide a novel, mechanistic insight into the complex means by which predators and forage conditions affect prey populations, and point to a need for more ecological studies that integrate behaviour, nutrition and demography. This line of inquiry can provide further insight into how NCEs interactively contribute to the dynamics of terrestrial prey populations; particularly, how predation risk-sensitive foraging has the potential to stabilize predator–prey coexistence.
Additional file 1 of Pathogens distribution and antimicrobial resistance in bloodstream infections in twenty-five neonatal intensive care units in China, 2017–2019
Creators: name: Liu, Jing
name: Fang, Zengyu
name: Yu, Yonghui
name: Ding, Yanjie
name: Liu, Zhijie
name: Zhang, Chengyuan
name: He, Haiying
name: Geng, Hongli
name: Chen, Weibing
name: Zhao, Guoying
name: Liu, Qiang
name: Wang, Baoying
name: Sun, Xueming
name: Wang, Shaofeng
name: Sun, Rongrong
name: Fu, Delong
name: Liu, Xinjian
name: Huang, Lei
name: Li, Jing
name: Xing, Xuexue
name: Wang, Xiaokang
name: Gao, Yanling
name: Zhu, Renxia
name: Han, Meiying
name: Peng, Fudong
name: Geng, Min
name: Deng, Liping
Publisher: name: figshare
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Additional file 1. Antimicrobial Resistance of Common EOS and HALOS Causing Pathogens at 25 NICUs, January 2017 - December 2019.
L'Archive ouverte UNIGE: Le dépôt numérique du patrimoine scientifique de l'Université
Creators: name: Bibliothèque de l'Université de Genève
Publisher: name: Université de Genève
Year: 2024
Subjects: Open Access
voie verte
institutional repository
Archive ouverte UNIGE

description: Poster utilisé à l'Université de Genève, durant la semaine internationale de l'Open Access, pour présenter l'Archive institutionelle des publications de membres de l'institution (= institutional repository).
L'Archive ouverte UNIGE: Le dépôt numérique du patrimoine scientifique de l'Université
Creators: name: Bibliothèque de l'Université de Genève
Publisher: name: Université de Genève
Year: 2023
Subjects: Open Access
voie verte
institutional repository

description: Poster utilisé à l'Université de Genève, durant la semaine internationale de l'Open Access, pour présenter l'Archive institutionelle des publications de membres de l'institution (= institutional repository).
Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig.
Creators: name: Rubanova, Yulia
name: Ruian Shi
name: Harrigan, Caitlin F
name: Roujia Li
name: Wintersinger, Jeff
name: Sahin, Nil
name: Deshwar, Amit
name: PCAWG Evolution And Heterogeneity Working Group
name: Quaid Morris
name: PCAWG Consortium
Publisher: name: The Francis Crick Institute
Year: 2020
Subjects: Genetics & Genomics
Human Biology & Physiology
Ecology,Evolution & Ethology
Tumour Biology
Computational & Systems Biology

description: The type and genomic context of cancer mutations depend on their causes. These causes have been characterized using signatures that represent mutation types that co-occur in the same tumours. However, it remains unclear how mutation processes change during cancer evolution due to the lack of reliable methods to reconstruct evolutionary trajectories of mutational signature activity. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole-genome sequencing data from 2658 cancers across 38 tumour types, we present TrackSig, a new method that reconstructs these trajectories using optimal, joint segmentation and deconvolution of mutation type and allele frequencies from a single tumour sample. In simulations, we find TrackSig has a 3-5% activity reconstruction error, and 12% false detection rate. It outperforms an aggressive baseline in situations with branching evolution, CNA gain, and neutral mutations. Applied to data from 2658 tumours and 38 cancer types, TrackSig permits pan-cancer insight into evolutionary changes in mutational processes.
Diferentes experiências, uma nova convivência
Creators: name: Azevedo, Cláudia
name: Palmeirão, Cristina
Publisher: name: Cadernos de Pedagogia Social
Year: 2012

description: A Educação Intergeracional ganha cada vez mais pertinência no mundo que é progressivamente mais vetusto e onde a longevidade das suas gentes atinge idades sem precedentes. Diferentes Experiências, uma Nova Convivência nasce e inscreve-se no âmbito do nosso trabalho de mestrado e é motivado pela necessidade de articular a pedagogia social e a pedagogia escolar. O insucesso e o abandono escolar de um número signifi cativo de jovens geram a necessidade de refl etir sobre o valor da escola e da educação no/para o futuro próximo destes jovens. Em termos metodológicos, o trabalho surge fundeado numa matriz de investigação qualitativa e visa promover a aprendizagem cooperativa, facilitar e reforçar as relações interpessoais e o sucesso educativo de jovens em situação de risco de abandono e/ou insucesso escolar. A finalidade é robustecer a aprendizagem cooperativa, a solidariedade intergeracional e derrubar velhos mitos sobre a pessoa idosa. Da discussão dos dados ressalta o impacto positivo dos programas de intervenção sociopedagógica e a necessidade maior de valorizar e reconhecer as práticas de educação intergeracional e articulação entre a pedagogia social e a pedagogia escolar.
description: Cadernos de Pedagogia Social, n. 4 (2012)
A short visit on Ising 2D Model
Creators: name: Damodar Rajbhandari
Publisher: name: figshare
Year: 2017
Subjects: subject: 20304 Thermodynamics and Statistical Physics
subject: FOS: Mechanical engineering
subject: Computational Physics
subject: Quantum Mechanics

description: This report aims to give a short description of the Ising two dimensional model and an introduction to Monte Carlo simulation. We focused on the magnetization results against temperature. To draw results, we implemented Metropolis Hastings algorithm which helps us to built likely configurations from any arbitary configurations.Due to the finite size of our lattice, it is difficult to specify the curie temperature. In order to approximate this temperature, we have used Binder Cumulant for different lattice sizes.We assume reader have some basic of probability theory and an everlasting curious.
2010 Navakatikyan MA Master's Dissertation 2010.pdf
Creators: name: Navakatikyan, Michael
Publisher: name: figshare
Year: 2017
Subjects: subject: Statistics
subject: FOS: Mathematics

description: Assessment of strength of association of EEG indices with post-menstrual age. Indices of the amplitude spread are highly associated with infant age and can serve as indicators of neonatal brain maturation.
DAWE_EHRXEA2
Creators: name: Prof. Pablo J. Zarco-Tejada
name: Dr. Tomas Poblete
Publisher: name: Zenodo
Year: 2022

description: This repository contains the datasets and the deliverables obtained and produced for the project EHRXEA2. The images were captured/processed by the University of Melbourne’s Airborne Remote Sensing Facility (HyperSens). The project was supported by the Department of Agriculture, Water and the Environment (DAWE)