title: ÐÑÐµÐ½ÐºÐ° ÑÐ¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸Ñ Ð¼Ð°Ð»Ð¾Ð½Ð¾Ð²Ð¾Ð³Ð¾ Ð´Ð¸Ð°Ð»ÑÐ´ÐµÐ³Ð¸Ð´Ð° Ð¸ Ð²Ð¾ÑÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð³Ð»ÑÑÐ°ÑÐ¸Ð¾Ð½Ð° Ð² ÑÐºÐ°Ð½ÑÑ Ð¿ÐµÑÐµÐ½Ð¸ Ð¸ Ð³Ð¾Ð»Ð¾Ð²Ð½Ð¾Ð³Ð¾ Ð¼Ð¾Ð·Ð³Ð° Ñ Ð¼ÑÑÐµÐ¹ Ñ Ð¸Ð½ÑÑÐ°ÐºÑÐ°Ð½Ð¸Ð°Ð»ÑÐ½ÑÐ¼Ð¸ Ð¾Ð¿ÑÑ Ð¾Ð»ÑÐ¼Ð¸ Ð¿ÑÐ¸ Ð»ÐµÑÐµÐ½Ð¸Ð¸ ÑÐµÐ¼Ð¾Ð·Ð¾Ð»Ð¾Ð¼Ð¸Ð´Ð¾Ð¼
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Assessment of the content of malondialdehyde and reduced glutathione in liver and brain tissues in mice with intracranial tumors during treatment with temozolomide
Creators: name: ÐÑÐ°Ð½Ð¸ÑÐ½Ð¸ÐºÐ¾Ð², ÐÐ»Ð°Ð´Ð¸ÑÐ»Ð°Ð²
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: ÑÐµÐ¼Ð¾Ð·Ð¾Ð»Ð¾Ð¼Ð¸Ð´
Ð½ÐµÐ²ÑÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ð¹ Ð´ÐµÑÐ¸ÑÐ¸Ñ
Ð¼Ð°Ð»Ð¾Ð½Ð¾Ð²ÑÐ¹ Ð´Ð¸Ð°Ð»ÑÐ´ÐµÐ³Ð¸Ð´
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Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð¾Ð¿ÑÑ Ð¾Ð»ÐµÐ²Ð°Ñ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ
temozolomide
neurological deficiency
malondialdehyde
reduced glutathione
antitumor activity

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description: In this work, the effect of temozolomide on the content of markers of oxidative stress (malondialdehyde) and antioxidant protection (reduced glutathione) in liver and brain tissues and neurological deficiency in mice with intracranially transplanted lymphosarcoma LIO-1 was studied. The object of the study is the chemotherapy drug temozolomide, mice with intracranially transplanted lymphosarcoma LIO-1. The subject of the study is a marker of oxidative stress â malondialdehyde and a marker of the antioxidant defense system â reduced glutathione in liver and brain tissues. The following databases and resources were used to complete the final qualification work: Scientific electronic library "eLibrary", national medical library "PubMed", electronic library "CyberLeninka". As a result, results were obtained showing that there is a pronounced pattern between the results of tests for the neurological assessment of the state of the nervous system (cognitive functions) of experimental animals and biochemical markers of oxidative stress (malondialdehyde) and antioxidant protection (reduced glutathione) of brain and liver tissue cells both against the background of the development of the tumor process and in the treatment of cancer diseases with the drug of the alkylating type of action of temozolomide. This research work provides a basis for further study of the mechanisms of the effects of chemotherapy drugs on the body and may be useful in developing strategies for the treatment of brain tumors.