cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Effectiveness of prevention programs for bullying and cyberbullying among children and adolescents: a meta-analysis of randomized controlled trials
Creators: name: Balan, Raluca
name: Dobrean, Anca
name: Brondino, Natascia
name: Politi, Pierluigi
name: Cristea, Ioana
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences
subject: bullying
subject: cyberbullying
subject: meta-analysis
subject: prevention

description: The present meta-analysis aims to evaluate the effectiviness for psychological prevention programs for bullying and cyberbullying amond children and adolescents both on bullying outcomes as well as on internalizing and externalizing problems. In addition, our aims is to evaluate which components of the programs are more effective in preventing bullying and cyberbullying.
Development of naringenin-O-alkylamine derivatives as multifunctional agents for the treatment of Alzheimer’s disease
Creators: name: Yang, Jing
name: Zhou, Yi
name: Ban, Yujuan
name: Mi, Jing
name: He, Ying
name: Li, Xinjuan
name: Liu, Zhengwei
name: Wang, Keren
name: Zhu, Gaofeng
name: Liu, Wenmin
name: Tan, Zhenghuai
name: Sang, Zhipei
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: In this study, a series of naringenin-O-alkylamine derivatives were designed and obtained by introducing an alkylamine fragment into the naringenin skeleton. The in vitro biological activity results revealed that compounds 5f and 7k showed good antioxidant activity with ORAC values of 2.3eq and 1.2eq, respectively. Compounds 5f and 7k were reversible and excellent huAChE inhibitors with IC50 values of 0.91 μM and 0.57 μM, respectively. Moreover, compounds 5f and 7k could inhibit self-induced Aβ1–42 aggregation with 62.1% and 43.8% inhibition rate, respectively, and significantly inhibited huAChE-Aβ1–40 aggregation with 51.7% and 43.4% inhibition rate, respectively. In addition, compounds 5f and 7k were selective metal chelators and remarkably inhibited Cu2+-induced Aβ1–42 aggregation with 73.5% and 68.7% inhibition rates, respectively. Furthermore, compounds 5f and 7k could cross the blood-brain barrier in vitro and displayed good neuroprotective effects and anti-inflammatory properties. Further investigation showed that compound 5f did not show obvious hepatotoxicity and displayed a good hepatoprotective effect by its antioxidant activity. The in vivo study displayed that compound 5f significantly improved scopolamine-induced mice memory impairment. Therefore, compound 5f was a potential multifunctional candidate for the treatment of AD.
Anisotropic Dyonic Black Brane and its Effects on Hydrodynamics
Creators: name: Khimphun, Sunly
name: Lee, Bum-Hoon
name: Park, Chanyong
name: Zhang, Yun-Long
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We construct $SL(2,R)$ invariant in anisotropic medium, with a dual anisotropic charged black hole geometry in massive gravity. We show how to obtain $SL(2,R)$ elements in terms of new degrees of freedom for Electromagnetic configuration, and construct the general expressions for conductivity with $SL(2,R)$ invariant. The holographic conductivities can be calculated using horizon data in an external magnetic field, and we show the numerical results using the linear response theory.
title: Die iberischen Bronzen von Maquíz
title: Die iberischen Bronzen von Maquíz
titleType: Subtitle
Creators: name: Jaeggi, Othmar
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 45 (2004)
description: Deutsche Zusammenfassung folgt.
Precision long-term measurements of beta-decay-rate ratios in a controlled environment
Creators: name: Bergeson, S. D.
name: Peatross, J. B.
name: Ware, M.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: We report on measurements of relative beta-decay rates of Na-22, Cl-36, Co-60, Sr-90, Cs-137 monitored for more than one year. The radioactive samples are mounted in an automated sample changer that sequentially positions the five samples in turn, with high spatial precision, in front of each of four Geiger-Müller tubes. The sample wheel, detectors, and associated electronics are housed inside a sealed chamber held at constant absolute pressure, humidity, and temperature to isolate the experiment from environmental variations. The statistical uncertainty in the count rate approaches a few times 0.01% with two weeks of averaging. Other sources of error are on a similar scale. The data are analyzed in variety of ways, comparing count rates of the various samples on one or more detectors, and comparing count rates of a particular sample across multiple detectors. We observe no statistically significant variations in the ratios of decay rates, either annual or at higher-frequency, at a level above 0.01%.
title: Sobre algunos moldes para elementos metálicos de prestigio del Bronce Final de Catalunya. Reflexiones sobre la funcionalidad y la especialización de los asentamientos a inicios del primer milenio a.C.
title: Sobre algunos moldes para elementos metálicos de prestigio del Bronce Final de Catalunya. Reflexiones sobre la funcionalidad y la especialización de los asentamientos a inicios del primer milenio a.C.
titleType: Subtitle
Creators: name:  Rovira Port, Jordi
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 45 (2004)
description: Fünf Sandformfragmente aus der endbronzezeitlichen Siedlung, die unter den Namen Punta de Corregó bzw. Cantaperdius I (La Portella, Lleida) bekannt ist, liefern im Negativ zahlreiche Daten zu Metallgegenständen, die von den Eliten des beginnenden 1. Jts. v. Chr. in der Region des Ebrounterlaufes Verwendung fanden. So ließ sich die Halterung eines Rasiermessers, den Typen Steinkirchen und Budishostice bzw. Lampertheimmit Anklägen an den Typ Obermenzing vergleichbar, idenitfizieren. Ferner bieten die Sandformen Hinweise auf eine Produktion von Schwertern des Typs Mantoche mit Anklängen an Schwertern des Typs Rosnöen und Monza, von Stäbchen und Sticheln, Ringen oder Nadeln mit Ringkopf und schließlich sehr wahrscheinlich Scheibchenanhängern mit Fortsätzen für Hals- und Brustschmuck oder vielleicht Nadeln mit Scheibenköpfen, ohne schließlich eventuelle Fibeln und Elemente von tintinnabula auzuschließen. Der keramische Kontext diese Platzes wie auch die angesprochenen Typen der Gussformen gehören in die Zeit der frühen Urnenfelderkulturen, deren Datierungen zwischen 1100 und 950 v. Chr. schwankt. Die Gussformen belegen jedenfalls die Herstellung von Objekten, die mitteleuropäischen Prototypen folgen bzw., sie nachahmen, von denen einige ihrer Form nach zurückgehen. Diese Produktionen schließlich scheinen insgesamt der besonderen Bedeutung dieses Platzes und der Stellung seiner Bewohner zu entsprechen, der an einem strategischen Punkt liegt, über dem río Noguera Ribagrorçana, einem Zufluß zum río Segre, der den Weg in Richtung Pyrenäen öffnet, und zu den Regionen, in denen vielleicht kupferhaltige Mineralien im Bereich des Oberlaufes dieses Flusses – wie auch des Noguera Pallaresa und des Cinca – abgebaut wurden.
Additional file 13 of Diverse proteins aggregate in mild cognitive impairment and Alzheimer’s disease brain
Creators: name: Kepchia, Devin
name: Huang, Ling
name: Dargusch, Richard
name: Rissman, Robert A.
name: Shokhirev, Maxim N.
name: Fischer, Wolfgang
name: Schubert, David
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health

description: Additional file 13: Table S2. Demographics of MCI and control individuals used for Western blot studies. Controls were classified as normal individuals.
High-Pressure Synthesis and Characterization of $β$-GeSe - A Semiconductor with Six-Rings in an Uncommon Boat Conformation
Creators: name: von Rohr, Fabian O.
name: Ji, Huiwen
name: Cevallos, F. Alexandre
name: Gao, Tong
name: Ong, N. Phuan
name: Cava, Robert J.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Two-dimensional materials have significant potential for the development of new devices. Here we report the electronic and structural properties of $β$-GeSe, a previously unreported polymorph of GeSe, with a unique crystal structure that displays strong two-dimensional structural features. $β$-GeSe is made at high pressure and temperature and is stable under ambient conditions. We compare it to its structural and electronic relatives $α$-GeSe and black phosphorus. The $β$ form of GeSe displays a boat conformation for its Ge-Se six-ring, while the previously known $α$ form, and black phosphorus, display the more common chair conformation for their six-rings. Electronic structure calculations indicate that $β$-GeSe is a semiconductor, with an approximate bulk band gap of $Δ~\approx$ 0.5 eV, and, in its monolayer form, $Δ~\approx$ 0.9 eV. These values fall between those of $α$-GeSe and black phosphorus, making $β$-GeSe a promising candidate for future applications. The resistivity of our $β$-GeSe crystals measured in-plane is on the order of $ρ\approx$ 1 $Ω$cm, while being essentially temperature independent.
Knowledge Evolution in Physics Research: An Analysis of Bibliographic Coupling Networks
Creators: name: Liu, Wenyuan
name: Nanetti, Andrea
name: Cheong, Siew Ann
Publisher: name: arXiv
Year: 2017
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Digital Libraries (cs.DL)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Even as we advance the frontiers of physics knowledge, our understanding of how this knowledge evolves remains at the descriptive levels of Popper and Kuhn. Using the APS publications data sets, we ask in this letter how new knowledge is built upon old knowledge. We do so by constructing year-to-year bibliographic coupling networks, and identify in them validated communities that represent different research fields. We then visualize their evolutionary relationships in the form of alluvial diagrams, and show how they remain intact through APS journal splits. Quantitatively, we see that most fields undergo weak Popperian mixing, and it is rare for a field to remain isolated/undergo strong mixing. The sizes of fields obey a simple linear growth with recombination. We can also reliably predict the merging between two fields, but not for the considerably more complex splitting. Finally, we report a case study of two fields that underwent repeated merging and splitting around 1995, and how these Kuhnian events are correlated with breakthroughs on BEC, quantum teleportation, and slow light. This impact showed up quantitatively in the citations of the BEC field as a larger proportion of references from during and shortly after these events.
description: 14 pages, 14 figures, 1 table
Rational design of biodegradable sulphonamide candidates treating septicaemia by synergistic dual inhibition of COX-2/PGE2 axis and DHPS enzyme
Creators: name: El-Dershaby, Nada H.
name: El-Hawash, Soad A.
name: Kassab, Shaymaa E.
name: Dabees, Hoda G.
name: Moneim, Ahmed E. Abdel
name: Wahab, Ibrahim A. Abdel
name: Abd-Alhaseeb, Mohammad M.
name: El-Miligy, Mostafa M. M.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: A new series of co-drugs was designed based on hybridising the dihydropteroate synthase (DHPS) inhibitor sulphonamide scaffold with the COX-2 inhibitor salicylamide pharmacophore through biodegradable linkage to achieve compounds with synergistic dual inhibition of COX-2/PGE2 axis and DHPS enzyme to enhance antibacterial activity for treatment of septicaemia. Compounds 5 b, 5j, 5n and 5o demonstrated potent in vitro COX-2 inhibitory activity comparable to celecoxib. 5j and 5o exhibited ED50 lower than celecoxib in carrageenan-induced paw edoema test with % PGE2 inhibition higher than celecoxib. Furthermore, 5 b, 5j and 5n showed gastric safety profile like celecoxib. Moreover, in vivo antibacterial screening revealed that, 5j showed activity against S.aureus and E.coli higher than sulfasalazine. While, 5o revealed activity against E.coli higher than sulfasalazine and against S.aureus comparable to sulfasalazine. Compound 5j achieved the target goal as potent inhibitor of COX-2/PGE2 axis and in vivo broad-spectrum antibacterial activity against induced septicaemia in mice.
title: Geschichte des Küstenverlaufs in der Bucht von Cádiz und San Fernando im Holozän
title: Geschichte des Küstenverlaufs in der Bucht von Cádiz und San Fernando im Holozän
titleType: Subtitle
Creators: name: Schulz, Horst
name: Barragán Mallofret, Daniel
name: Becker, Veith
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 45 (2004)
description: Deutsche Zusammenfassung folgt.
title: Geschichte des Küstenverlaufs im Stadtgebiet von Cádiz
title: Geschichte des Küstenverlaufs im Stadtgebiet von Cádiz
titleType: Subtitle
Creators: name:  Arteaga Matute,  Oswaldo
name: Kölling, Annette
name: Kölling, Martin
name:  Roos, Anna-Maria
name: Schulz, Helga
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 45 (2004)
description: Deutsche Zusammenfassung folgt.
title: Frühbronzezeitliche Kontakte im westlichen und zentralen Mittelmeerraum und die Rolle der Iberischen Halbinsel
title: Frühbronzezeitliche Kontakte im westlichen und zentralen Mittelmeerraum und die Rolle der Iberischen Halbinsel
titleType: Subtitle
Creators: name: Schuhmacher, Thomas Xaver
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 45 (2004)
description: Deutsche Zusammenfassung.
Rational design, optimization, and biological evaluation of novel α-Phosphonopropionic acids as covalent inhibitors of Rab geranylgeranyl transferase
Creators: name: Małolepsza, Joanna
name: Marchwicka, Aleksandra
name: Serwa, Remigiusz A.
name: Niinivehmas, Sanna P.
name: Pentikäinen, Olli T.
name: Gendaszewska-Darmach, Edyta
name: Błażewska, Katarzyna M.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Rab geranylgeranyltransferase (GGTase-II, RGGT) catalyses the post-translational modification of eukaryotic Rab GTPases, proteins implicated in several pathologies, including cancer, diabetes, neurodegenerative, and infectious diseases. Thus, RGGT inhibitors are believed to be a potential platform for the development of drugs and tools for studying processes related to the abnormal activity of Rab GTPases. Here, a series of new α-phosphonocarboxylates have been prepared in the first attempt of rational design of covalent inhibitors of RGGT derived from non-covalent inhibitors. These compounds were equipped with electrophilic groups capable of binding cysteines, which are present in the catalytic cavity of RGGT. A few of these analogues have shown micromolar activity against RGGT, which correlated with their ability to inhibit the proliferation of the HeLa cancer cell line. The proposed mechanism of this inhibitory activity was rationalised by molecular docking and mass spectrometric measurements, supported by stability and reactivity studies.
Shareholder Protection Law in Malaysia: Its Character, Evolution and Effectiveness
Creators: name: VIVIEN JEAN HUI CHEN
Publisher: name: Monash University
Year: 2018
Subjects: subject: 150303 Corporate Governance and Stakeholder Engagement
subject: FOS: Economics and business

description: Malaysian companies have often been perceived as attractive investments, in part due to shareholder protection law modelled on international best practices. The thesis measures the comparative international strength of legal protections for shareholders of Malaysian companies. It analyses the effectiveness of the law in safeguarding shareholders from expropriation of corporate assets and investigates the manner in which specific features of the Malaysian context affect the operation of shareholder protection mechanisms. The research considers the way in which historical, sociocultural, economic and political influences have collectively shaped Malaysian shareholder protection law and its effectiveness in safeguarding shareholder interests.
Phosphorus containing analogues of SAHA as inhibitors of HDACs
Creators: name: Pun, Michael D.
name: Wu, Hsin-Hua
name: Olatunji, Feyisola P.
name: Kesic, Britany N.
name: Peters, John W.
name: Berkman, Clifford E.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Histone deacetylases (HDACs) are a family of enzymes responsible for regulating DNA transcription by modulating its binding to histone proteins. HDACs are overexpressed in several types of cancers and are recognised as drug targets. Vorinostat, or suberanilohydroxamic acid (SAHA), is an histone deacetylase (HDAC) inhibitor with a hydroxamic acid as a zinc-binding group (ZBG), and it has been FDA approved for the treatment of T-cell lymphoma. In this work, phosphorus-based SAHA analogues were synthesised to assess their zinc-binding effectiveness compared to the hydroxamic acid of SAHA. Specifically, we examined phosphate, phosphoramidate and phosphorothiolate groups as isosteres of the canonical hydroxamic acid motif of conventional HDAC inhibitors. The compounds were screened for binding to HDAC enzymes from HeLa cell lysate. The most potent derivatives were then screened against HDAC3 and HDAC8 isoforms. HDAC inhibition assays demonstrated that these phosphorus-based SAHA analogs exhibited slow binding to HDACs but with greater potency than phosphonate SAHA analogs examined previously. All compounds inhibited HDACs, the most potent having an IC50 of 50 µM.
Synthesis and biological activity evaluation of 3-(hetero) arylideneindolin-2-ones as potential c-Src inhibitors
Creators: name: Princiotto, Salvatore
name: Musso, Loana
name: Manetti, Fabrizio
name: Marcellini, Valentina
name: Maga, Giovanni
name: Crespan, Emmanuele
name: Perini, Cecilia
name: Zaffaroni, Nadia
name: Beretta, Giovanni Luca
name: Dallavalle, Sabrina
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biochemistry
Medicine
Neuroscience
Pharmacology
Chemical Sciences not elsewhere classified
Cancer

description: Inhibition of c-Src is considered one of the most studied approaches to cancer treatment, with several heterocyclic compounds approved during the last 15 years as chemotherapeutic agents. Starting from the biological evaluation of an in-house collection of small molecules, indolinone was selected as the most promising scaffold. In this work, several functionalised indolinones were synthesised and their inhibitory potency and cytotoxic activity were assayed. The pharmacological profile of the most active compounds, supported by molecular modelling studies, revealed that the presence of an amino group increased the affinity towards the ATP-binding site of c-Src. At the same time, bulkier derivatizations seemed to improve the interactions within the enzymatic pocket. Overall, these data represent an early stage towards the optimisation of new, easy-to-be functionalised indolinones as potential c-Src inhibitors.
title: Studien zum Grab 111 der Nekropole von Fuente Álamo (Almería)
title: Studien zum Grab 111 der Nekropole von Fuente Álamo (Almería)
titleType: Subtitle
Creators: name: Schubart, Hermanfrid
name: Pingel, Volker
name: Kunter, Manfred
name: Liesau von Lettow-Vorbeck, Corina
name: Pozo, Manuel
name: Medina , José Antonio
name: Casas, José
name: Juan i Tresseras, Jordi
name: Hägg, Inga
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 45 (2004)
description: Deutsche Zusammenfassung folgt.
Analysing Temporal Evolution of Interlingual Wikipedia Article Pairs
Creators: name: Gottschalk, Simon
name: Demidova, Elena
Publisher: name: arXiv
Year: 2017
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences

description: Wikipedia articles representing an entity or a topic in different language editions evolve independently within the scope of the language-specific user communities. This can lead to different points of views reflected in the articles, as well as complementary and inconsistent information. An analysis of how the information is propagated across the Wikipedia language editions can provide important insights in the article evolution along the temporal and cultural dimensions and support quality control. To facilitate such analysis, we present MultiWiki - a novel web-based user interface that provides an overview of the similarities and differences across the article pairs originating from different language editions on a timeline. MultiWiki enables users to observe the changes in the interlingual article similarity over time and to perform a detailed visual comparison of the article snapshots at a particular time point.
description: Published in the SIGIR '16 Proceedings of the 39th International ACM SIGIR conference on Research and Development in Information Retrieval
title: Almizaraque and the Early Copper Metallurgy of Southeast Spain. New Data
title: Almizaraque and the Early Copper Metallurgy of Southeast Spain. New Data
titleType: Subtitle
Creators: name: Müller, Roland
name: Rehren, Thilo
name: Rovira Llorens, Salvador
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: lala

description: Madrider Mitteilungen, Vol. 45 (2004)
description: Deutsche Zusammenfassung folgt.
INCIDENCE DE LA VOLATILITÉ DES PRIX DES SURGELÉS SUR LE BIEN-ÊTRE DES MÉNAGES DANS LA VILLE PROVINCE DE KINSHASA : cas des poissons chinchards
Creators: name: Vangila Muziedje Franck
name: Lonzo Lubu Gastonfils
Publisher: name: Zenodo
Year: 2024

description: Ce papier poursuit l’objectif d’étudier l’interaction entre la volatilité des prix des surgelés et ses conséquences sur le bien-être des ménages dans la Ville-province de Kinshasa. Ainsi, les questions suivantes devraient trouver une réponse dans ce travail : (i) Qu’est-ce qui est à la base de la volatilité des prix des surgelés particulièrement les poissons chinchards sur le marché, cause de l’instabilité ? (ii) Quelles sont les conséquences de la volatilité des prix des surgelés sur le bien être des ménages. Pour y parvenir, les auteurs ont développé deux hypothèses suivantes : (i) la volatilité des prix sur le marché cause des conséquences néfastes sur le bien-être des ménages, une mauvaise alimentation, une immense souffrance et privation, (ii) la volatilité en hausse éprouve des difficultés d’achats aux ménages et diminue la quantité des biens dans le panier de la ménagère.Ainsi, grâce à la méthode basée sur l’analyse des propriétés de base combinée de l’analyse de contingence au moyen de la statistique de Khi-deux, nous avons sélectionné 182 ménages répartis dans 4 districts sur 25 sites composés des marchés et autres carrefours pour la période allant du 02 au 20 Février 2024.  Cette étude nous a permis de vérifier nos hypothèses de recherche en ce sens que 90,7% des ménages enquêtés affirment qu’il y a bel et bien volatilité de prix des surgelés ; 78,0% des sujets affirment que leurs rythmes de consommation avaient été modifiés suite à la volatilité ; 58,2% des personnes enquêtées disent qu’il serait de leurs avantages si le prix des chinchards baissait et ça aurait amélioré le bien être des ménages. En d’autres termes, la volatilité de prix des produits surgelés sur le marché est un facteur destructeur des ménages, car tant que cette volatilité demeure sur le marché, le ménage ne saurait retrouver sa satisfaction, pour un pays dont l’Etat ne régule pas le prix ce qui confirme notre hypothèse de base. Ainsi, il sied de rappeler qu’une bonne alimentation est le souhait de tout peuple.
Design, synthesis, and biological evaluation of potent FAK-degrading PROTACs
Creators: name: Qin, Qiaohua
name: Wang, Ruifeng
name: Fu, Qinglin
name: Zhang, Guoqi
name: Wu, Tianxiao
name: Liu, Nian
name: Lv, Ruicheng
name: Yin, Wenbo
name: Sun, Yin
name: Sun, Yixiang
name: Zhao, Dongmei
name: Cheng, Maosheng
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biophysics
Biochemistry
Cell Biology
Molecular Biology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Developmental Biology
Cancer

description: FAK mediated tumour cell migration, invasion, survival, proliferation and regulation of tumour stem cells through its kinase-dependent enzymatic functions and kinase-independent scaffolding functions. At present, the development of FAK PROTACs has become one of the hotspots in current pharmaceutical research to solve above problems. Herein, we designed and synthesised a series of FAK-targeting PROTACs consisted of PF-562271 derivative 1 and Pomalidomide. All compounds showed significant in vitro FAK kinase inhibitory activity, the IC50 value of the optimised PROTAC A13 was 26.4 nM. Further, A13 exhibited optimal protein degradation (85% degradation at 10 nM). Meantime, compared with PF-562271, PROTAC A13 exhibited better antiproliferative activity and anti-invasion ability in A549 cells. More, A13 had excellent plasma stability with T1/2 >194.8 min. There are various signs that PROTAC A13 could be useful as expand tool for studying functions of FAK in biological system and as potential therapeutic agents.
Precision measurement of the rotational energy-level structure of the three-electron molecule He$_2^+$
Creators: name: Semeria, Luca
name: Jansen, Paul
name: Merkt, Frédéric
Publisher: name: arXiv
Year: 2017
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: The term values of all rotational levels of the $^4$He${_2}^+\,X^+\,^2Σ_u^+\,(ν^+=0)$ ground vibronic state with rotational quantum number $N^+\le 19$ have been determined with an accuracy of 8 x 10$^{-4}$ cm$^{-1}$ ($\sim{25}$ MHz) by MQDT-assisted Rydberg spectroscopy of metastable He$_2^*$. Comparison of these term values with term values recently calculated ab initio by Tung et al. [J. Chem. Phys. 136, 104309 (2012)] reveal discrepancies that rapidly increase with increasing rotational quantum number and reach values of 0.07 cm$^{-1}$ ($\sim{2.1}$ GHz) at $N^+=19$.
description: 11 pages, 6 figures
Design and synthesis of new indole drug candidates to treat Alzheimer’s disease and targeting neuro-inflammation using a multi-target-directed ligand (MTDL) strategy
Creators: name: Lamie, Phoebe F.
name: Abdel-Fattah, Maha M.
name: Philoppes, John N.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: A novel series of indole-based compounds was designed, synthesised, and evaluated as anti-Alzheimer’s and anti-neuroinflammatory agents. The designed compounds were in vitro evaluated for their AChE and BuChE inhibitory activities. The obtained results revealed that compound 3c had higher selectivity for AChE than BuChE, while, 4a, 4b, and 4d showed selectivity for BuChE over AChE. Compounds 5b, 6b, 7c, and 10b exerted dual AChE/BuChE inhibitory activities at nanomolar range. Compounds 5b and 6b had the ability to inhibit the self-induced Aβ amyloid aggregation. Different anti-inflammatory mediators (NO, COX-2, IL-1β, and TNF-α) were assessed for compounds 5b and 6b. Cytotoxic effect of 5b and 6b against human neuroblastoma (SH-SY5Y) and normal hepatic (THLE2) cell lines was screened in vitro. Molecular docking study inside rhAChE and hBuChE active sites, drug-likeness, and ADMET prediction were performed.
Deterministic enhancement of coherent photon generation from a nitrogen-vacancy center in ultrapure diamond
Creators: name: Riedel, Daniel
name: Söllner, Immo
name: Shields, Brendan J.
name: Starosielec, Sebastian
name: Appel, Patrick
name: Neu, Elke
name: Maletinsky, Patrick
name: Warburton, Richard J.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The nitrogen-vacancy (NV) center in diamond has an optically addressable, highly coherent spin. However, an NV center even in high quality single-crystalline material is a very poor source of single photons: extraction out of the high-index diamond is inefficient, the emission of coherent photons represents just a few per cent of the total emission, and the decay time is large. In principle, all three problems can be addressed with a resonant microcavity. In practice, it has proved difficult to implement this concept: photonic engineering hinges on nano-fabrication yet it is notoriously difficult to process diamond without degrading the NV centers. We present here a microcavity scheme which uses minimally processed diamond, thereby preserving the high quality of the starting material, and a tunable microcavity platform. We demonstrate a clear change in the lifetime for multiple individual NV centers on tuning both the cavity frequency and anti-node position, a Purcell effect. The overall Purcell factor $F_{\rm P}=2.0$ translates to a Purcell factor for the zero phonon line (ZPL) of $F_{\rm P}^{\rm ZPL}\sim30$ and an increase in the ZPL emission probability from $\sim 3 \%$ to $\sim 46 \%$. By making a step-change in the NV's optical properties in a deterministic way, these results pave the way for much enhanced spin-photon and spin-spin entanglement rates.
description: 6 pages, 4 figures
title: Polished Stone Artefacts at the Prehistoric Settlement of Leceia (Oeiras)
title: Polished Stone Artefacts at the Prehistoric Settlement of Leceia (Oeiras)
titleType: Subtitle
Creators: name: Cardoso, João Luís
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 45 (2004)
description: Deutsche Zusammenfassung folgt.
Additional file 1 of Region-specific distribution of Olig2-expressing astrocytes in adult mouse brain and spinal cord
Creators: name: Wang, Hui
name: Xu, Liang
name: Lai, Chuying
name: Hou, Kaiyu
name: Chen, Junliang
name: Guo, Yaowei
name: Sambangi, Abhijeet
name: Swaminathan, Shreya
name: Xie, Chunming
name: Wu, Zheng
name: Chen, Gong
Publisher: name: figshare
Year: 2021
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology

description: Additional file 1: Table S1. Zeiss Confocal imaging acquisition parameters. Table S2. The proportion (%) of S100β+ and Sox9+ cells with Olig2 signal in different CNS regions. Figure S1. The percentage of SOX9+ cells co-labeled with Olig2 in different adult mouse CNS regions.
title: Inscriptional Versus Pictorial Invocation to God
title: Inscriptional Versus Pictorial Invocation to God
titleType: Subtitle
Creators: name: Noack-Haley, Sabine
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 46 (2005)
description: Follows.
Point-contact spectroscopy of superconducting YBaCuO single crystals of tetragonal modification
Creators: name: Yanson, I. K.
name: Rybal'chenko, L. F.
name: Fisun, V. V.
name: Bobrov, N. L.
name: Demirskii, V. V.
name: Mitkevich, V. V.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: The point-contact spectra of tetragonal $\rm YBa_2Cu_3O_{7-δ}$ with $T_c=50-60~K$ are studied at various temperatures. The single-electron energy ($2Δ_0/kT_c\simeq 17$) and its temperature dependence are determined. The characteristic energies of quasiparticle excitations interacting with conduction electrons in this high-$T_c$. superconductor are found to correlate with the characteristic phonon energies. The possibility of a pair gap, which increases with temperature, is revealed near the critical temperature.
description: 4 pages, 3 figures
Examining transnational care circulation trajectories within immobilizing regimes of migration: Implications for proximate care
Creators: name: Merla, Laura
name: Kilkey, Majella
name: Baldassar, Loretta
Publisher: name: JFR - Journal of Family Research
Year: 2020

description: In this paper we argue that the current political context of restrictionist migration policies is dramatically affecting people’s capacity to cross borders to engage in proximate care with their relatives, which is a central, yet often overlooked, feature of transnational care practices. We examine how the wider context of temporality, restrictive mobility, and heightened uncertainty about the future affect people’s ability to be mobile and to move back and forth for caregiving. In examining the wellbeing effects of such restrictions, we highlight their variable impact depending on factors such as socio-economic positioning, life-course stage and health. The first sections of the paper present the care circulation framework and the particular meaning and function of proximate forms of care, as well as the main categories of care-related mobility that support this. We illustrate the dynamics and challenges faced by transnational family members, who engage in these care-related mobilities, through three vignettes involving care circulation between India and the UK, China and Australia, and Morocco and Belgium. In the final section, we discuss our vignettes in relation to the political, physical, social and time dimensions of current regimes of mobility that impact on care-related mobilities. We argue that the regimes of mobility that currently govern care-related mobilities are best understood as ‘immobilizing regimes’ with important and undervalued implications for ontological security and wellbeing.
description: JFR - Journal of Family Research, Early View
title: Zur Verbreitung und Herkunft der Polyederohrringe im südwestlichen Mittelmeerraum
title: Zur Verbreitung und Herkunft der Polyederohrringe im südwestlichen Mittelmeerraum
titleType: Subtitle
Creators: name: Eger, Christoph
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 46 (2005)
description: Deutsche Zusammenfassung folgt.
title: Anmerkungen zur Belegungsabfolge und Beigabensitte im spätantiken Gräberfeld von El Ruedo (Almedinilla, Prov. Córdoba)
title: Anmerkungen zur Belegungsabfolge und Beigabensitte im spätantiken Gräberfeld von El Ruedo (Almedinilla, Prov. Córdoba)
titleType: Subtitle
Creators: name: Eger, Christoph
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: lala

description: Madrider Mitteilungen, Vol. 46 (2005)
description: Deutsche Zusammenfassung folgt.
Developing a theoretical foundation to change road user behavior and improve traffic safety: Driving under the influence of cannabis (DUIC)
Creators: name: Ward, Nicholas J.
name: Schell, William
name: Kelley-Baker, Tara
name: Otto, Jay
name: Finley, Kari
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objectives: This study explored a theoretical model to assess the influence of culture on willingness and intention to drive under the influence of cannabis (DUIC). This model is expected to guide the design of strategies to change future DUIC behavior in road users. Methods: This study used a survey methodology to obtain a nationally representative sample (n = 941) from the AmeriSpeak Panel. Survey items were designed to measure aspects of a proposed definition of traffic safety culture and a predictive model of its relationship to DUIC. Results: Although the percentage of reported past DUIC behaviors was relatively low (8.5%), this behavior is still a significant public health issue—especially for younger drivers (18–29 years), who reported more DUIC than expected. Findings suggest that specific cultural components (attitudes, norms) reliably predict past DUIC behavior, general DUIC willingness, and future DUIC intention. Most DUIC behavior appears to be deliberate, related significantly to willingness and intention. Intention and willingness both appear to fully moderate the relationship between traffic safety culture and DUIC behavior. Conclusions: This study explored a theoretical model to understand road user behavior involving drug (cannabis)-impaired driving as a significant risk factor for traffic safety. By understanding the cultural factors that increase DUIC behavior, we can create strategies to transform this culture and sustain safer road user behavior.
title: Römische Theater in der Baetica
title: Römische Theater in der Baetica
titleType: Subtitle
Creators: name: Jansen, Brita
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Theater
subject: Baetica
subject: theatre
subject: Baetica
subject: teatros
subject: Baetica

description: Madrider Mitteilungen, Vol. 46 (2005)
description: Deutsche Zusammenfassung folgt.
title: Die Wiederentdeckung von Munigua. Abriss der Forschungsgeschichte
title: Die Wiederentdeckung von Munigua. Abriss der Forschungsgeschichte
titleType: Subtitle
Creators: name: Schattner, Thomas G.
Publisher: name: Deutsches Archäologisches Institut
Year: 2020
Subjects: subject: Munigua
subject: Munigua
subject: Mulva

description: Madrider Mitteilungen, Vol. 46 (2005)
description: Deutsche Zusammenfassung folgt.
title: Die Altäre des L. Sestius Quirinalis bei Kap Finisterre. Zur geopolitischen Konstruktion des römischen Herrschaftsraums
title: Die Altäre des L. Sestius Quirinalis bei Kap Finisterre. Zur geopolitischen Konstruktion des römischen Herrschaftsraums
titleType: Subtitle
Creators: name: Grüner, Andreas
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 46 (2005)
description: Deutsche Zusammenfassung folgt.
Triggering Process of the X1.0 Three-ribbon Flare in the Great Active Region NOAA 12192
Creators: name: Bamba, Yumi
name: Inoue, Satoshi
name: Kusano, Kanya
name: Shiota, Daikou
Publisher: name: arXiv
Year: 2017
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The solar magnetic field in a flare-producing active region (AR) is much more complicated than theoretical models, which assume a very simple magnetic field structure. The X1.0 flare, which occurred in AR 12192 on 2014 October 25, showed a complicated three-ribbon structure. To clarify the trigger process of the flare and to evaluate the applicability of a simple theoretical model, we analyzed the data from Hinode/Solar Optical Telescope and the Solar Dynamics Observatory/Helioseismic and Magnetic Imager, Atmospheric Imaging Assembly. We investigated the spatio-temporal correlation between the magnetic field structures, especially the non-potentiality of the horizontal field, and the bright structures in the solar atmosphere. As a result, we determined that the western side of the positive polarity, which is intruding on a negative polarity region, is the location where the flare was triggered. This is due to the fact that the sign of the magnetic shear in that region was opposite that of the major shear of the AR, and the significant brightenings were observed over the polarity inversion line (PIL) in that region before flare onset. These features are consistent with the recently proposed flare-trigger model that suggests that small reversed shear (RS) magnetic disturbances can trigger solar flares. Moreover, we found that the RS field was located slightly off the flaring PIL, contrary to the theoretical prediction. We discuss the possibility of an extension of the RS model based on an extra numerical simulation. Our result suggests that the RS field has a certain flexibility for displacement from a highly sheared PIL, and that the RS field triggers more flares than we expected.
title: Das Promontorium Magnum. Zur antiken Geographie der hispanischen Atlantikküste
title: Das Promontorium Magnum. Zur antiken Geographie der hispanischen Atlantikküste
titleType: Subtitle
Creators: name: Guerra ,  Amílcar
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 46 (2005)
description: Deutsche Zusammenfassung folgt.
Kondo correlations formation and the local magnetic moment dynamics in the Anderson model
Creators: name: Maslova, N. S.
name: Arseyev, P. I.
name: Mantsevich, V. N.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We investigated the typical time scales of the Kondo correlations formation for the single-state Anderson model, when coupling to the reservoir is switched on at the initial time moment. The influence of the Kondo effect appearance on the system non-stationary characteristics was analyzed and discussed.
description: 5 pages, 2 figures
Hydroxyurea for lifelong transfusion-dependent β-thalassemia: A meta-analysis
Creators: name: Algiraigri, Ali H.
name: Wright, Nicola A.M.
name: Paolucci, Elizabeth Oddone
name: Kassam, Aliya
Publisher: name: Taylor & Francis
Year: 2018
Subjects: Medicine
Science Policy

description: Objective: Chronic blood transfusion remains the most feasible therapeutic option for lifelong transfusion-dependent β-thalassemia (lifelong TDβT). However, it is associated with serious risks and complications. Hydroxyurea (HU), an oral chemotherapeutic drug, is expected to increase hemoglobin levels, thereby minimizing the burden of blood transfusion and its complications. Growing literature over the last twenty years suggests promising results of the use HU in lifelong TDβT; however, its role and safety remain unanswered questions. The objective of this study was to evaluate the clinical efficacy and safety of HU in patients with lifelong TDβT. Methods: MEDLINE, EMBASE, Cochrane databases, and major preceding conferences for studies that assessed HU in lifelong TDβT patients were searched. The effect size was estimated as a proportion (responder/sample size). Results: Eleven observational studies, collectively involving 859 patients, fulfilled eligibility criteria. HU was associated with a significant decrease in transfusion need with complete and overall (≥50%) response rates of 26% [95% confidence interval (CI), 13–41%] and 60% (95% CI, 41–78%), respectively. No serious adverse effects were reported. All of the studies had several limitations, such as lack of a comparison group. Conclusion: HU appears to be effective, well tolerated; however, large randomized clinical trials should be done to confirm such findings
Additional file 18 of Diverse proteins aggregate in mild cognitive impairment and Alzheimer’s disease brain
Creators: name: Kepchia, Devin
name: Huang, Ling
name: Dargusch, Richard
name: Rissman, Robert A.
name: Shokhirev, Maxim N.
name: Fischer, Wolfgang
name: Schubert, David
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health

description: Additional file 18: Table S7. Lower molecular weight proteins that migrate above 200 kDa on SDS-polyacrylamide gels.
TNP and its analogs: Modulation of IP6K and CYP3A4 inhibition
Creators: name: Lee, Seulgi
name: Park, Bernie Byeonghoon
name: Kwon, Hongmok
name: Kim, Vitchan
name: Jeon, Jang Su
name: Lee, Rowoon
name: Subedi, Milan
name: Lim, Taehyeong
name: Ha, Hyunsoo
name: An, Dongju
name: Kim, Jaehoon
name: Kim, Donghak
name: Kim, Sang Kyum
name: Kim, Seyun
name: Byun, Youngjoo
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Inositol hexakisphosphate kinase (IP6K) is an important mammalian enzyme involved in various biological processes such as insulin signalling and blood clotting. Recent analyses on drug metabolism and pharmacokinetic properties on TNP (N2-(m-trifluorobenzyl), N6-(p-nitrobenzyl)purine), a pan-IP6K inhibitor, have suggested that it may inhibit cytochrome P450 (CYP450) enzymes and induce unwanted drug-drug interactions in the liver. In this study, we confirmed that TNP inhibits CYP3A4 in type I binding mode more selectively than the other CYP450 isoforms. In an effort to find novel purine-based IP6K inhibitors with minimal CYP3A4 inhibition, we designed and synthesised 15 TNP analogs. Structure-activity relationship and biochemical studies, including ADP-Glo kinase assay and quantification of cell-based IP7 production, showed that compound 9 dramatically reduced CYP3A4 inhibition while retaining IP6K-inhibitory activity. Compound 9 can be a tool molecule for structural optimisation of purine-based IP6K inhibitors.
title: São Miguel da Mota (Alandroal, Portugal) 2002. Bericht über die Ausgrabungen im Heiligtum des Endovellicus
title: São Miguel da Mota (Alandroal, Portugal) 2002. Bericht über die Ausgrabungen im Heiligtum des Endovellicus
titleType: Subtitle
Creators: name: Guerra,  Amílcar
name: Schattner, Thomas G.
name: Fabião, Carlos
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 46 (2005)
description: Deutsche Zusammenfassung folgt.
title: Monte do Facho 2003. Bericht über die Ausgrabungen im Heiligtum des Berobreus
title: Monte do Facho 2003. Bericht über die Ausgrabungen im Heiligtum des Berobreus
titleType: Subtitle
Creators: name: Schattner, Thomas G.
name: Suárez Otero, José
name: Koch, Michael
Publisher: name: Deutsches Archäologisches Institut
Year: 2020

description: Madrider Mitteilungen, Vol. 46 (2005)
description: Deutsche Zusammenfassung folgt.