cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
sj-pdf-1-imr-10.1177_03000605231213212 - Supplemental material for CT and 18FDG-PET/CT findings in progressive mediastinal idiopathic fibrosis as a benign mimicker of esophageal carcinoma: a case report
Creators: name: Mitrovic-Jovanovic, Milica
name: Skrobic, Ognjan
name: Odalovic, Strahinja
name: Djikic Rom, Aleksandra
name: Plavsic, Aleksandra
name: Jankovic, Aleksandra
name: Kostadinovic, Milena
name: Ivanovic, Nenad
name: Simic, Aleksandar
name: Djuric-Stefanovic, Aleksandra
name: Kovac, Jelena Djokic
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: Health and Community Services
subject: Cardiology
subject: Dentistry not elsewhere classified
subject: Emergency Medicine
subject: Endocrinology
subject: Geriatrics and Gerontology
subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Nursing not elsewhere classified
subject: Nutrition and Dietetics not elsewhere classified
subject: Oncology and Carcinogenesis not elsewhere classified
subject: Orthopaedics
subject: Sports Medicine
subject: Otorhinolaryngology
subject: Aged Health Care
subject: Paediatrics
subject: Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: Psychology not elsewhere classified
subject: Psychiatry (incl. Psychotherapy)
subject: Public Health and Health Services not elsewhere classified
subject: Respiratory Diseases
subject: Sociological Methodology and Research Methods
subject: Surgery

description: Supplemental material, sj-pdf-1-imr-10.1177_03000605231213212 for CT and 18FDG-PET/CT findings in progressive mediastinal idiopathic fibrosis as a benign mimicker of esophageal carcinoma: a case report by Milica Mitrovic-Jovanovic, Ognjan Skrobic, Strahinja Odalovic, Aleksandra Djikic Rom, Aleksandra Plavsic, Aleksandra Jankovic, Milena Kostadinovic, Nenad Ivanovic, Aleksandar Simic, Aleksandra Djuric-Stefanovic and Jelena Djokic Kovac in Journal of International Medical Research
Peptidergic innervation of the olfactory bulb: a sleep/wake-regulatory route through the nose
Creators: name: Tesoriero, Chiara
name: Lorenzetto, Erika
name: Laperchia, Claudia
name: Bentivoglio, Marina
Publisher: name: Firenze University Press
Year: 2017
Subjects: Orexin/hypocretin; MCH; connectomics; olfactory bulb; sleep

description: Olfactory epithelium receptor neurons in the nasal cavity, which are exposed to the external environment, reach the olfactory bulb (OB), representing a direct port of entry to the brain. Through retrograde axonal transport, pathogens, toxins and misfolded proteins can reach brain cell groups which innervate the OB and result in functional alterations. Indeed, influenza virus nasal instillation was found to target brainstem and hypothalamic cell groups and result in narcoleptic-like sleep/wake changes [1]. These cell groups included the wake-promoting orexin (OX)-containing neurons, and the sleep-promoting melanin-concentrating hormone (MCH)-containing neurons [1]. Orexinergic innervation of the OB has been reported, but OX and MCH neurons innervating the OB have never been visualized. OX immunoreactivity in the mouse olfactory receptor neurons has been ascribed to the olfactory mucosa. Sources of input to the OB have been studied [2] before the discovery of OX in 1998. Orexinergic innervation of the prefrontal cortex is instead well established. Aim of this study was to reveal OX- and MCH-containing neurons projecting to the OB. Unilateral injections of the retrograde fluorescent tracer Fluoro-Gold (FG) confined to the OB of adult mice were combined with immunophenotyping and quantitative analysis of retrogradely labeled neurons. The findings were compared with those obtained after FG injections in the prefrontal cortex. Following FG injections in the OB, labeled neurons were found in the ipsilateral lateral hypothalamus, and included intermingled OX-A- or MCH-immunoreactive cells. About 8% of orexinergic neurons were labeled when the tracer was confined to the OB. This proportion increased (13±2.49 %) in cases in which a faint halo of tracer diffusion to the lateral portion of the prefrontal cortex was observed. Preliminary data indicate retrograde labeling from the OB of almost 15% of MCH-containing neurons. The findings demonstrate that OX and MCH neurons reach the OB directly, thus providing to environmental agents a route to sleep/wake-regulatory nodes via the nasal cavity.
description: Italian Journal of Anatomy and Embryology, Vol. 121, No. 1 (Supplement) 2016
Neuroendocrine circuits controlling food intake: a target for endocrine disruptors
Creators: name: Panzica, Giancarlo
name: Bo, Elisabetta
name: Marraudino, Marilena
name: Farinetti, Alice
name: Eva, Carolina
name: Gotti, Stefano
Publisher: name: Firenze University Press
Year: 2017
Subjects: Neuropeptide Y; tributyltin; pesticides; hypothalamus; transgenic mice

description: Tributyltin (TBT), a pesticide used in antifouling paints, is toxic for aquatic invertebrates. In vertebrates, TBT may act in obesogen- inducing adipogenetic gene transcription for adipocyte differentiation (1). In a previous study, we demonstrated that acute administration of TBT induces c-fos expression in the arcuate nucleus (2). Therefore, in this study, we tested the hypothesis that adult exposure to TBT may alter a part of the nervous pathways controlling animal food intake (3). In particular, we investigated the expression of neuropeptide Y (NPY) immunoreactivity. This neuropeptide forms neural circuits dedicated to food assumption and its action is mediated by Y1 receptors that are widely expressed in the hypothalamic nuclei responsible for the regulation of food intake and energy homeostasis. To this purpose, TBT was orally administered at a dose of 0.025 mg/kg/day/body weight to adult animals [male and female C57BL/6 (Y1-LacZ transgenic mice] for 4 weeks. No differences were found in body weight and fat deposition, but we observed a significant increase in feed efficiency in TBT-treated male mice and a significant decrease in circulating leptin in both sexes. Computerized quantitative analysis of NPY immunoreactivity and Y1-related b-galactosidase activity demonstrated a statistically significant reduction in NPY and Y1 transgene expression in the hypothalamic circuit controlling food intake of treated male mice in comparison with controls. In conclusion, the present results indicate that adult exposure to TBT is profoundly interfering with the nervous circuits involved in the stimulation of food intake.
description: Italian Journal of Anatomy and Embryology, Vol. 121, No. 1 (Supplement) 2016
sj-DOC-1-inq-10.1177_00469580231214469 – Supplemental material for Individual-Level Health Care Costs Attributable to Noncommunicable Diseases: A Longitudinal Study Based on the Older Adults in China
Creators: name: Zhao, Shi-qi
name: Zhao, Li-ping
name: Xu, Xin-peng
name: You, Hua
Publisher: name: SAGE Journals
Year: 2023
Subjects: Nursing not elsewhere classified

description: Supplemental material, sj-DOC-1-inq-10.1177_00469580231214469 for Individual-Level Health Care Costs Attributable to Noncommunicable Diseases: A Longitudinal Study Based on the Older Adults in China by Shi-qi Zhao, Li-ping Zhao, Xin-peng Xu and Hua You in INQUIRY: The Journal of Health Care Organization, Provision, and Financing
Nüw gsangbüchle von vil schönen Psalmen und geistlichen liedern
Creators: name: Zwick, Johannes
Publisher: name: bey Christoffel Froschouer
Year: 1540

description: durch diener der Kirchen zu Costentz unn anderstwo mercklichen gemeert, gebessert und in gschickte ordnung zesamen gstellt zu übung unnd bruch jrer ouch anderer Christlichen Kirchen ; [Mit Vorrede von Johannes Zwick]
1 Brief an Hans Georg Nägeli
Brief an Nägeli ...
Creators: name: Kanton Bern. Erziehungs-Departement
name: Neuhaus, Charles
name: Hünerwadel, Samuel Gottlieb
Publisher: name: [s.n.]
Year: 1833

description: von Erziehungs-Departement der Republ[ik] Bern, C[harles] Neuhaus, [Samuel] G[ottlieb] Hünerwadel
description: Unterzeichnet vom Präsidenten des Erziehungsdepartements Charles Neuhaus und dem ersten Sekretär Samuel Gottlieb Hünerwadel
Characterization of the autophagoproteasome a novel cell clearing organelle in eukaryotic cells
Creators: name: Lenzi, Paola
name: Fulceri, Federica
name: Gambardella, Stefano
name: Cantini, Federica
name: Ryskalin, Larissa
name: Lazzeri, Gloria
name: Fornai, Francesco
Publisher: name: Firenze University Press
Year: 2017
Subjects: Autophagy; proteasome; ubiquitination; protein clearing pathways

description: The autophagy (ATG) and Ubiquitin-Proteasome (UP) pathways clear proteins and membranes from eukaryotic cells. Their dysfunction is associated with systemic diseases, and neuronal degeneration. These pathways are commonly viewed as independent biochemical steps owing pathway-specific enzymatic activity taking place within different, site specific cell domains. While ATG is placed within a double/multiple membrane structure named autophagosome, the UP pathway is viewed as a protein complex dispersed in the cytosol. Scattered recent data provided functional evidence suggesting an interplay between ATG and UP. We recently provided morphological and biochemical evidence suggesting the existence of a close relationship between ATG and UP which may converge to form a novel organelle named autophagoproteasome. In the present study we characterized the autophagoproteasome by using various experimental approaches in vitro and in vivo. We studied the autophagoproteasomes in baseline conditions, following mTOR inhibition, and during specific neurotoxic treatments. The quantitative evaluation of ATG and UP component within autophagoproteasomes was carried out by confocal microscopy and ultrastructural morphometry. The number of autophagoproteasomes increases following mTOR inhibition. Again, specific neurotoxins as well as endogenous neurotransmitters modulate the expression of autophagoproteasomes. Remarkably, within autophagoproteasomes the relative amount of ATG compared with UP components varies depending on experimental conditions. Despite its morphological novelty the autophagoproteasome appears to be the organelle where ATG and UP (originally regarded to be independent structures) co-exist and share the catalytic activity. In addition, ATG and UP co-immunoprecipitate, suggesting a reciprocal binding and functional interplay. We thank Maria Concetta Scavuzzo for technical assistance.
description: Italian Journal of Anatomy and Embryology, Vol. 121, No. 1 (Supplement) 2016
Membrane protein remodeling in microglia exposed to amyloid peptides
Creators: name: Fabrizi, Cinzia
name: Pompili, Elena
name: Maras, Bruno
name: Mignogna, Giuseppina
name: Di Francesco, Laura
name: Correani, Virginia
name: Schininà, Maria Eugenia
name: Fumagalli, Lorenzo
Publisher: name: Firenze University Press
Year: 2017
Subjects: Microglia; Alzheimer’s disease; neurodegeneration

description: Infection, neurodegeneration, and other conditions associated with loss of brain homeostasis, induce changes in microglial morphology, gene expression and function, generally referred to as “activation”. Alzheimer’s disease (AD) is the most common dementia and is characterized by neuroinflammatory changes, including alterations in the morphology and distribution of microglia and astrocytes, and deposition of complement and other inflammatory mediators. Our previous observations show that microglial cells challenged in vitro with amyloid peptides clustered and rounded up, dramatically changing their morphology. Besides, in these cells we observed the early acetylation and then the phosphorylation of STAT3 which is required for the expression of the epsilon isoform of 14-3-3, a marker of Abeta-activated microglia (1, 2). We applied affinity partitioning approach combined with high throughput mass spectrometric analysis in order to identify variation of proteins on plasma membrane of BV2 immortalized microglia upon treatment with amyloid peptides. By this method several proteins up- or down-regulated by amyloid treatment were identified in microglial plasma membrane. Among them annexins (5 and 7), IFITM3 and MARK3. These data have been confirmed in primary microglial cultures.
description: Italian Journal of Anatomy and Embryology, Vol. 121, No. 1 (Supplement) 2016
1 Brief an Hans Georg Nägeli
Brief an Nägeli ...
Creators: name: Kanton Bern. Erziehungs-Departement
name: Neuhaus, Charles
name: Hünerwadel, Samuel Gottlieb
Publisher: name: [s.n.]
Year: 1833

description: von Erziehungs-Departement der Republik Bern, C[harles] Neuhaus, [Samuel] G[ottlieb] Hünerwadel
description: Unterzeichnet vom Präsidenten des Erziehungsdepartements Charles Neuhaus und dem ersten Sekretär Samuel Gottlieb Hünerwadel
Agn-Enhanced Outflows Of Low-Ionization Gas In Star-Forming Galaxies At 1.7
Creators: name: Talia, Margherita
name: Brusa, Marcella
name: Cimatti, Andrea
name: VUDS Team
Publisher: name: Zenodo
Year: 2017
Subjects: Outflows
AGN
High-redshift

description: To reproduce the properties of galaxies in the local Universe, as well as the scaling relations between host galaxies and black holes properties, many galaxy formation models invoke the presence of fast and energetic winds extending over galaxy scales. These massive gas outflows can be powered either by star-formation (SF) or AGN activity, though the relative dominance and efficiency of the different mechanisms is not yet fully understood.

In the last decade much effort has been put in the search for observational evidence of such phenomena, especially at the peak of both SF and AGN activity through cosmic time (1<z<3), in an attempt to explain the rapid quenching of SF and the link between the evolution of AGNs and their host galaxies. Spectroscopy at different wavelengths is the most powerful tool to find and investigate outflows. Blue-shifted inter-stellar medium (ISM) absorption lines in the UV regime, as well as broad, blue-shifted and asymmetric profiles in ionised permitted and forbidden optical emission lines (e.g. [OIII]5007, Hα) have been observed in galaxies at all redshifts and are usually interpreted as evidence of fast material moving towards our line of sight. More recently, especially thanks to new facilities like ALMA, outflows are being observed also in neutral and molecular gas.

We collected a large sample of AGNs and SFGs at z>1 from large optical spectroscopic surveys (zCOSMOS, VUDS, ESO public surveys), complemented with HST imaging, X-ray (Chandra) and IR data, and we concentrated our analysis on the ISM absorption lines in the rest-frame UV wavelength range. The analysis of the ISM absorption lines in stacked spectra confirmed that galaxies hosting an AGN show outflows moving at speeds (~600-800 km/s) much faster than in the case of pure SFGs. However, though the AGN might be responsible of an enhanced gas outflow activity with respect to SF alone, the analysis of the sample also shows that there is no correlation between the power of the AGN, as traced by its X-ray luminosity, and the velocity of the warm phase of the outflow traced by the ISM UV absorption lines. This result is at odds with previous findings reported for the highly ionized phase in local AGN, suggesting that the two phases of the outflow are mixed only in relatively low-velocity outflows.
Rheinische Beiträge zur Gelehrsamkeit
Creators: name: [s.n.]
Publisher: name: Verlag der Hof- und Akademischen Buchhandlung
Year: 1777
Subjects: GEISTESWISSENSCHAFTEN

description: Jg. 1 (1777/78)-2 (1778/79) ; 1780-1781, Band 1-2.
title: Nachhaltige Verkehrskonzepte unter besonderer Berücksichtigung des Alpenraumes
Creators: name: Ledermueller, Stefan
Year: 2008

description: Die vorliegenden Arbeit "Nachhaltige Verkehrskonzepte. Unter besonderer Berücksichtigung des Alpenraumes", beschäftigt sich mit dem Personenverkehr und dessen negativen Auswirkungen für Menschen und Umwelt. Dabei wird auf verschiedene Personengruppen und Rahmenbedingungen eingegangen. Auch Ursachen der Verkehrsentwicklung, wie beispielsweise bedeutende Erreichbarkeitsverbesserungen des motorisierten Individualverkehrs werden dargestellt. Es werden Lösungswege zur Verringerung der Verkehrsleistung, das heißt einer starken Verflechtung der Lebensraumfunktionen, zu Verkehrsverlagerung von motorisierten Individualverkehr auf die anderen Verkehrsarten und zu Effizienzsteigerung des Verkehrs durch Erhöhung des Besetzungsgrad beziehungsweise durch technologische Verbesserung erläutert. Dabei werden Einflussmöglichkeiten zur Umsetzung nachhaltiger Verkehrskonzepte auf den unterschiedlicher Maßstabsebene wie der EU, sowie auf nationaler und regionaler Ebene, erörtert. Auf den Alpenraum wird dabei besonderes Augenmerk gelegt.
description: The diploma thesis is about negative influences of passenger transport on human beings and environment. Various person groups especially seniors are described. Different causes for the transport upgrowth such as increasing accessibility of the car traffic are presented. Answers to reduce volume of traffic, e. g. through integration of work and life, shifting of car traffic and raising efficiency of traffic for example by Carsharing or technology improvements. The possibilities of implementation of sustainable traffic concepts are discussed on different scales, such as the EU, national and regional level. The particularities of the alpine regions are mentioned too.
Glareani Dōdekachordon : plagii A Hypodorius Hypermixolydius Ptolemaei B Hypophrygius Hyperaeolius Mar. Cap. C Hypolydius D Hypomixolyd. ...
Creators: name: Glareanus, Henricus Loriti
Publisher: name: [Heinrich Petri]
Year: 1547

description: "Basileae per Henricum Petri mense Septembri anno post virginis partum. M.D.XLVII." - Kolophon
sj-docx-1-jaf-10.1177_0148558X231203436 – Supplemental material for Explaining Returns Through Valuation
Creators: name: Johannesson, Erik
name: Ohlson, James A.
Publisher: name: SAGE Journals
Year: 2023
Subjects: Organisation and Management Theory

description: Supplemental material, sj-docx-1-jaf-10.1177_0148558X231203436 for Explaining Returns Through Valuation by Erik Johannesson and James A. Ohlson in Journal of Accounting, Auditing & Finance
Additional file 2 of Interference of pseudorabies virus infection on functions of porcine granulosa cells via apoptosis modulated by MAPK signaling pathways
Creators: name: Deng, Lingcong
name: Min, Wenpeng
name: Guo, Songyangnian
name: Deng, Jiping
name: Wu, Xiaosong
name: Tong, Dewen
name: Yuan, Anwen
name: Yang, Qing
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Supplementary Material 2
Cell-to-cell communication within the neurovascular unit (NVU) in a model of cerebral cortex demyelination
Creators: name: Virgintino, Daniela
name: Errede, Mariella
name: Longo, Giovanna
name: Girolamo, Francesco
name: Roncali, Luisa
Publisher: name: Firenze University Press
Year: 2017

description: The concept of neurovascular unit (NVU) emphasizes the critical role of cell-to-cell interaction and communication between glial, neuronal, and vascular cell components during blood-brain barrier (BBB) development, and in adult normal and pathological conditions. In this study we have analysed the involvement of the nerve glial antigen 2, NG2, a chondroitin sulphate proteoglycan, highly expressed in developing and adult CNS, in cell cross-talk within the NVU. During CNS development NG2 is expressed by activated pericyte and appears downregulated as these cells undergo terminal differentiation. NG2 has also been identified on the surface of oligodendrocyte precursor cells, OPCs, evenly distributed throughout the CNS already by the end of the first postnatal week in mice and throughout adulthood. In a previous study on cerebral cortex experimental autoimmune encephalomyelitis (EAE) in mice, we firstly observed and described the glia-limitans-like position of NG2-bearing OPCs that during neuroinflammation extend processes to the pial surface and acquire a perivascular arrangement, coming in contact with the wall of EAE cortex microvessels. With the aim of understanding if a subset of OPCs specifically contributes to the cell composition of the NVU during EAE, we have explored, by morphometric analyses applied to laser confocal microscopy, OPCs distribution and vascular relationships in the cerebral cortex of WT controls and naïve NG2KO and in EAE WT and EAE NG2KO mice, at both early (20 dpi) and late (40 dpi) disease stages. In EAE WT mice, juxtavascular (JV) and perivascular (PV) OPCs were identified in a higher number compared to healthy mice. On the contrary, absence of NG2 in EAE NG2 KO mice seemed to affect the proliferative response of OPCs, specifically inhibiting the emergence of the JV and PV OPC subsets. The results indicate that in WT mice during EAE, the NVU microenvironment, classically formed by perivascular astrocytes, receives the insertion of OPCs as a specific vascular subset and suggest NG2 as the molecule involved in the observed NVU damage.
description: Italian Journal of Anatomy and Embryology, Vol. 121, No. 1 (Supplement) 2016
1 Brief an Hans Georg Nägeli
Brief an Nägeli ...
Creators: name: Kanton Bern. Erziehungs-Departement
name: Schneider, Johann
name: Schärer, Friedrich
Publisher: name: [s.n.]
Year: 1834

description: von Erzieh[ung]s-Departement [Kanton Bern], [Johann] Schneider, F[riedrich] Schärer
description: Unterzeichnet vom Vize-Präsidenten des Erziehungsdepartements Johann Schneider und dem zweiten Sekretär Friedrich Schärer
Cadmium-induced neurotoxicity: impairment of the blood brain barrier
Creators: name: Branca, Jacopo Junio Valerio
name: Maresca, Mario
name: Morucci, Gabriele
name: Di Cesare Mannelli, Lorenzo
name: Ghelardini, Carla
name: Gulisano, Massimo
name: Pacini, Alessandra
Publisher: name: Firenze University Press
Year: 2017
Subjects: Cadmium; BBB permeability; pannexin-1

description: Cadmium (Cd), an ubiquitous heavy metal, known to be accumulated outside of the blood–brain barrier (1) and to cause neurotoxicity, has also been demonstrated to induce an increase in the blood–brain barrier (BBB) permeability (2). Key components of BBB integrity are primarily the tight junctions (TJs) between adjacent brain microvascular endothelial cells that confers low paracellular permeability, making the barrier to function (3). Cd-dependent BBB alterations are elicited by a caspase-3 activation-dependent pathway (4) that triggers the irreversible open of pannexin-1 (panx-1) (5), a large transmembrane channel that allows an ATP massive spillage (6), imparing the neurovascular unit (NVU) homeostasis (7). In this study, we investigated the Cd cytotoxicity in a rat brain endothelial cell line (RBE4). Results from the cell viability assay showed that Cd caused a remarkable decrease in cell viability in a dose-dependent manner. 10 µM Cd induced caspase 3 activation and an increment in extracellular ATP concentration, indicative for a panx-1 involvement. The increase of BBB permeability was evaluated analyzing zonula occludens-1 (ZO-1) expression levels and its subcellular dislocation. ZO-1 is a protein localized on the plasma membrane in areas of cell-cell contact that acts as a crucial central regulator of the structural organization of the TJs (8). The presence of Cd 10 µM caused a significative reduction of ZO-1 expression levels (as determined by western blot technique) and an altered distribution of this protein (analyzed by immunofluorescence) that appears patchy or faded away from membrane areas. Summarizing, these data offer an initial image of the NVU homeostasis impairment induced by Cd, suggesting Panx-1 as a novel target to counteract its neurotoxicity.
description: Italian Journal of Anatomy and Embryology, Vol. 121, No. 1 (Supplement) 2016
sj-docx-1-jme-10.1177_10525629231215798 – Supplemental material for Promoting a Contemporary Image of Entrepreneurial Careers: A Course Concept to Address Gender Role Stereotypes Through Entrepreneurship Education
Creators: name: Sundermeier, Janina
name: Steenblock, Conny
Publisher: name: SAGE Journals
Year: 2023
Subjects: Organisation and Management Theory

description: Supplemental material, sj-docx-1-jme-10.1177_10525629231215798 for Promoting a Contemporary Image of Entrepreneurial Careers: A Course Concept to Address Gender Role Stereotypes Through Entrepreneurship Education by Janina Sundermeier and Conny Steenblock in Journal of Management Education
PAR1 activation induces the release by Schwann cells of factors promoting cell survival and neuritogenesis
Creators: name: Pompili, Elena
name: Fabrizi, Cinzia
name: Maras, Bruno
name: Correani, Virginia
name: Schininà, Maria Eugenia
name: Ciraci, Viviana
name: Artico, Marco
name: Fumagalli, Lorenzo
Publisher: name: Firenze University Press
Year: 2017
Subjects: Protease-activated receptor 1; thrombin; peripheral nerve; Schwann cells

description: Schwann cells (SCs) regulate a wide variety of axonal functions in the peripheral nervous system, providing a supportive growth environment following nerve injury (1). Here we show that rat SCs express the protease-activated receptor-1 (PAR1) both in vivo and in vitro. PAR1 is a G-protein coupled receptor eliciting cellular responses to thrombin and other proteases (2). To investigate if PAR1 activation affects the neurotrophic properties of SCs, this receptor was activated by a specific agonist peptide (TFLLR) and the conditioned medium was transferred to PC12 pheocromocytoma cells for assessing cell survival and neurite outgrowth. Culture medium from SCs treated with 10 µM TFLLR reduced significantly the release of LDH and increased the viability of PC12 cells with respect to the medium of the untreated SCs. Furthermore, conditioned medium from TFLLR-treated SCs increased neurite outgrowth on PC12 cells respect to control medium from untreated cells. To identify putative neurotrophic candidates we performed proteomic analysis on SC secretoma and real time PCR experiments after PAR1 activation. Stimulation of SCs with TFLLR increased specifically the release of a subset of five proteins: Macrophage migration inhibitory factor (Mif), Aldose reductase (Akr1b1), Matrix metalloproteinase-2 (Mmp2), Syndecan-4 (Sdc) and Decorin (Dcn). At the same time there was a significant decrease in the level of three proteins: Complement C1r subcomponent (C1r), Complement component 1 Q subcomponent-binding protein (C1qbp) and Angiogenic factor with G patch and FHA domains 1 (Aggf1). These data indicate that PAR1 stimulation does induce the release by SCs of factors promoting cell survival and neuritogenesis. Among these proteins, Mif, Sdc, Dcn and Mmp2 are of particular interest.
description: Italian Journal of Anatomy and Embryology, Vol. 121, No. 1 (Supplement) 2016
sj-docx-2-car-10.1177_19476035231213184 – Supplemental material for Postoperative Management of Osteochondral Lesions of the Ankle: A Survey Among German-Speaking Foot and Ankle Surgeons
Creators: name: Matthias, Aurich
name: Becher, Christoph
name: Ettinger, Sarah
name: Gottschalk, Oliver
name: Guenther, Daniel
name: Klos, Kajetan
name: Ahrend, Marc-Daniel
name: Körner, Daniel
name: Plaass, Christian
name: Walther, Markus
Publisher: name: SAGE Journals
Year: 2023
Subjects: Orthopaedics
Sports Medicine
Surgery
Biological Sciences not elsewhere classified

description: Supplemental material, sj-docx-2-car-10.1177_19476035231213184 for Postoperative Management of Osteochondral Lesions of the Ankle: A Survey Among German-Speaking Foot and Ankle Surgeons by Aurich Matthias, Christoph Becher, Sarah Ettinger, Oliver Gottschalk, Daniel Guenther, Kajetan Klos, Marc-Daniel Ahrend, Daniel Körner, Christian Plaass and Markus Walther in CARTILAGE
Supplemental Material - Being Alone or Together: How Frontline Anthropomorphized Robots Affect Solo (vs. Joint) Service Consumption
Creators: name: Khoa, Do The
name: Chan, Kimmy Wa
Publisher: name: SAGE Journals
Year: 2023
Subjects: Organisation and Management Theory
Hospitality Management

description: Supplemental Material for Being Alone or Together: How Frontline Anthropomorphized Robots Affect Solo (vs. Joint) Service Consumption by Do The Khoa and Kimmy Wa Chan in Journal of Service Research
sj-docx-1-jet-10.1177_15266028231215215 – Supplemental material for Meta-Analysis of Duplex Surveillance Following Lower Limb Endovascular Intervention
Creators: name: McKenna, Mervyn
name: Elghazaly, Hussein
name: Bergman, Henry
name: Wingate, Laura
name: Robbins, Dan
name: Davies, Alun H.
name: Thapar, Ankur
Publisher: name: SAGE Journals
Year: 2023
Subjects: Cardiology
Medicine
Surgery

description: Supplemental material, sj-docx-1-jet-10.1177_15266028231215215 for Meta-Analysis of Duplex Surveillance Following Lower Limb Endovascular Intervention by Mervyn McKenna, Hussein Elghazaly, Henry Bergman, Laura Wingate, Dan Robbins, Alun H. Davies and Ankur Thapar in Journal of Endovascular Therapy
title: Demokratisierung durch äußeres Engagement am Fallbeispiel Chile
Creators: name: Bogdanovic, Milos
Year: 2008

description: Mit der vorliegenden Arbeit wollte ich, den Verlauf der politischen Ereignisse in Chile in der Periode 1970 – 1990 darzustellen. Die vorwiegende Absicht der Arbeit war, eine Analyse des chilenischen Übergangsprozesses zur Demokratie durchzuführen, sowie das Phänomen des Zusammenhangs der diktatorialen Vergangenheit mit der demokratischen Tradition des chilenischen Staates zu analysieren. In der Arbeit werden verschiedene Faktoren der chilenischen Transitionsgesellschaft analysiert. Der Schwerpunkt der Arbeit liegt in den Perioden um die Jahre 1973 und 1988, wobei die Zeitspanne vor dem Putsch 1973 sowie die Zeit der Diktatur als zusätzliche Erklärungsfelder des Phänomens des chilenischen Falles dienen. Mit Berücksichtigung zweier wissenschaftlicher Konzepte, des Engagement-Konzeptes und der neokonservativen These „Beseitigung des Tyrannen“ habe ich die Arbeit theoretisch erläutert. Das Konzept der Arbeit legt eine Akteuren- und Politikfeldanalyse dar. Sie untersucht das Politikfed von Internationalen Politik. Unter bestimmten Rahmenbedingungen geht es in diesem um die politische Inhalte eines Staates innerhalb bestimmter Zeitabschnitte. Der Fokus wird auf die Analyse dieser politischen Inhalte gelegt. Es wird von der Hauptthese ausgegen, wie sich das politische Handeln und die daraus resultierenden politischen Inhalte auf dem Feld der Internationalen Politik durch den chilenischen Putsch unter gewisen Rahmenbedingungen geäußert haben.
经修订的有关外国在美国直接投资的国家安全审查程序
Creators: Plotkin, Mark E.
Fagan, David N.
Publisher: name: Columbia University
Year: 2009
Subjects: Finance

description: 2008年12月22日，规定美国政府对外国并购美国企业进行国家安全审查程序的新规则生效。这是修改和加强美国外国投资委员会（CFIUS） 审查的漫长努力的最后一步。
Oxidative stress related to obesity: results in plasma and brain areas of obese Zucker rats
Creators: name: Tomassoni, Daniele
name: Khosrow Tayebati, Seyed
name: Martinelli, Ilenia
name: Moruzzi, Michele
name: Amenta, Francesco
Publisher: name: Firenze University Press
Year: 2017
Subjects: Obesity; oxidative stress; brain; obese Zucker rats

description: Oxidative stress may be a consequence and/or cause of several pathologies, such as diabetes, metabolic syndrome (MetS) and cerebrovascular disease. Oxidative stress is also tightly bound to the physiological condition of obese individuals. The obese Zucker rats (OZRs), with a mutation in leptin receptors represent a model of type II diabetes mellitus, characterized by the simultaneous occurrence of obesity, hyperglycemia, hyperinsulinemia, hyperlipidemia and moderate hypertension similar to MetS. The present study has investigated oxidative stress alterations occurring in OZR compared to Lean Zucker Rats (LZRs) of 12, 16 and 20 weeks of age. Thiobarbituric acid reactive substance (TBARS), gluthatione-peroxidase (GPX) and superoxide dismutase (SOD) activity, oxidative state of protein and the expression of 8-hydroxy-2’deoxyguanosine (8-oxo-dG) as a nuclear marker, were evaluated in plasma and in various brain areas (frontal cortex and hippocampus) of rats at different age. OZRs were characterized by higher body weight, an increase of systolic pressure, glycemia, triglycerides and cholesterol values in comparison with age-matched LZRs. An age-dependent increase of these parameters was observed in OZRs. TBARS values were higher in plasma of OZRs at all ages. The SOD activity was decreased in plasma of OZRs whereas GPx activity did not show differences between lean and obese rats. Oxi-blot analysis showed an obvious increase of oxidative state of proteins on obese rats samples, particularly in the 20-weeks-old rats. In frontal cortex the TBARS values were higher in 20-weeks-old OZRs, but no difference was found in hippocampus. The enzyme activity decreased, whereas the oxidative status of protein increased in the brain of OZRs compared to age-matched LZRs. An increase of nuclear 8-oxo-dG immunofluorescence detection was revealed both in frontal cortex and hippocampus neurons of 20-weeks-old LZRs. These findings demonstrate an increase in lipid peroxidation, protein carbonylation and an alteration of enzyme activity, suggesting an increase of oxidative stress in plasma and in the brain of OZRs. These observations consistent with previous studies, confirm that the increase of oxidative stress is associated with metabolic complications in OZRs. In terms of practical consequences these data may help to better manage MetS progression and the correlations with neurodegenerative processes.
description: Italian Journal of Anatomy and Embryology, Vol. 121, No. 1 (Supplement) 2016
Additional file 1 of Association between psychiatric disorders and glioma risk: evidence from Mendelian randomization analysis
Creators: name: Yang, Wenzhuo
name: Han, Yu
name: He, Changjia
name: Zhong, Sheng
name: Ren, Fei
name: Chen, Zhongping
name: Mou, Yonggao
name: Sai, Ke
Publisher: name: figshare
Year: 2024
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Mental Health

description: Supplementary Table 1 Summary of 8 glioma GWAS datasets
1 Brief an Hans Georg Nägeli
Brief an Nägeli ...
Creators: name: Kanton Bern. Erziehungs-Departement
name: Neuhaus, Charles
name: Schärer, Friedrich
Publisher: name: [s.n.]
Year: 1834

description: von Erzieh[ung]s-Departem[en]t der Republik Bern, C[harles] Neuhaus, F[riedrich] Schärer
description: Unterzeichnet vom Präsidenten des Erziehungsdepartements Charles Neuhaus und dem zweiten Sekretär Friedrich Schärer
sj-docx-1-scm-10.1177_00369330231213981 - Supplemental material for Reboot coaching programme: a mixed-methods evaluation assessing resilience, confidence, burnout and depression in medical students
Creators: name: Johnson, Judith
name: Pointon, Lucy
name: Talbot, Rebecca
name: Coleman, Rebecca
name: Budworth, Luke
name: Simms-Ellis, Ruth
name: Vogt, Katharina
name: Tsimpida, Dialechti
name: Biyani, Chandra Shekha
name: Harrison, Reema
name: Cheung, Gloria
name: Melville, Colin
name: Jayagopal, Vijay
name: Lea, William
Publisher: name: SAGE Journals
Year: 2023
Subjects: Medicine

description: Supplemental material, sj-docx-1-scm-10.1177_00369330231213981 for Reboot coaching programme: a mixed-methods evaluation assessing resilience, confidence, burnout and depression in medical students by Judith Johnson, Lucy Pointon, Rebecca Talbot, Rebecca Coleman, Luke Budworth, Ruth Simms-Ellis, Katharina Vogt, Dialechti Tsimpida, Chandra Shekha Biyani, Reema Harrison, Gloria Cheung, Colin Melville, Vijay Jayagopal and William Lea in Scottish Medical Journal
Numerical investigation of spallation neutrons generated from petawatt-scale laser-driven proton beams
Creators: name: Martinez, B.
name: Chen, S. N.
name: Bolaños, S.
name: Blanchot, N.
name: Boutoux, G.
name: Cayzac, W.
name: Courtois, C.
name: Davoine, X.
name: Duval, A.
name: Horny, V.
name: Lantuejoul, I.
name: Deroff, L. Le
name: Masson-Laborde, P. E.
name: Sary, G.
name: Vauzour, B.
name: Smets, R.
name: Gremillet, L.
name: Fuchs, J.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Nuclear Experiment (nucl-ex)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: Due to their high cost of acquisition and operation, there are still a limited number of high-yield, high-flux neutron source facilities worldwide. In this context, laser-driven neutron sources offer a promising, cheaper alternative to those based on large-scale accelerators, with, in addition, the potential of generating compact neutron beams of high brightness and ultra-short duration. In particular, the predicted capability of next-generation petawatt (PW)-class lasers to accelerate protons beyond the 100 MeV range should unlock efficient neutron generation through spallation reactions. In this paper, this scenario is investigated numerically through particle-in-cell and Monte Carlo simulations, modeling, respectively, the laser acceleration of protons from thin-foil targets and their subsequent conversion into neutrons in secondary heavy-ion targets. Laser parameters relevant to the 1 PW LMJ-PETAL and 1-10 PW Apollon systems are considered. Under such conditions, neutron fluxes exceeding $10^{23}\,\rm n\,cm^{-2}\,s^{-1}$ are predicted, opening up attractive fundamental and applicative prospects.
description: 16 pages, 13 figures
1 Brief an Hans Georg Nägeli
Brief an Nägeli ...
Creators: name: Kanton Bern. Erziehungs-Departement
name: Neuhaus, Charles
name: Jahn, Carl
Publisher: name: [s.n.]
Year: 1834

description: von Erziehungs-Departement der Republik Bern, C[harles] Neuhaus, C[arl] Jahn
description: Unterzeichnet vom Präsidenten des Erziehungsdepartements Charles Neuhaus und dem provis. Sekretär und Adjunkt Carl Jahn
Diastematomyelia of the dorsal spinal cord.
Creators: name: Navarro BaÃ±O, Antonio
Publisher: name: EURORAD
Year: 2017
Subjects: subject: Neuroradiology spine
subject: CT
subject: Diagnostic procedure
subject: Congenital

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: female, 65 years
description: Clinical History: A 65-years-old woman with a CT performed by thyroid cancer and assessment of its extension. Final Diagnosis: Diastematomyelia of the dorsal spinal cord.
1 Brief an Hans Georg Nägeli
Brief an Nägeli ...
Creators: name: Aargau. Erziehungsrat
name: Dorer, Franz Ludwig Fidelis
name: Wagner, Franz Xaver
Publisher: name: [s.n.]
Year: 1833

description: von Schulrath des Kantons Aargau, [Franz Ludwig Fidelis Dorer?], [Franz Xaver?] Wagner
description: Unterzeichnet von Dorer (?), Regierungsrat, Präsident, wahrscheinlich Franz Ludwig Fidelis Dorer (schlecht lesbar), und Wagner, Regierungssekretär, wahrscheinlich Franz Xaver Wagner
Active control of a diode laser with injection locking
Creators: name: Chen, Ziting
name: Seo, Bojeong
name: Huang, Mingchen
name: Parit, Mithilesh K.
name: Chen, Peng
name: Jo, Gyu-Boong
Publisher: name: arXiv
Year: 2021
Subjects: subject: Optics (physics.optics)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: We present a simple and effective method to implement an active stabilization of a diode laser with injection locking, which requires minimal user intervenes. The injection locked state of the diode laser is probed by a photodetector, of which sensitivity is enhanced by a narrow laser-line filter. Taking advantage of the characteristic response of laser power to spectral modes from the narrow laser-line filter, we demonstrate that high spectral purity and low intensity noise of the diode can be simultaneously maintained by an active feedback to the injected laser. Our method is intrinsically cost-effective, and does not require bulky devices, such as Fabry-Perot interferometers or wavemeters, to actively stabilize the diode laser. Based on successful implementation of this method in our quantum gas experiments, it is conceivable that our active stabilization will greatly simplify potential applications of injection locking of diode lasers in modularized or integrated optical systems.
description: 5 pages, 5 figures
title: Der Tourismus und seine Gäste
Creators: name: Punz, Bianca
Year: 2008

description: Die hier vorliegende Arbeit beschäftigt sich mit unterschiedlichen Gästetypen, die speziell in einem niederösterreichischen Dorf vorkommen. Innerhalb eines Jahres wurden zahlreiche ero-epische Gespräche und Beobachtungsprotokolle geführt, die die Verfasserin zu folgenden Ergebnissen, kommen ließ: Einerseits bedient sich ein Kellner oder eine Kellnerin besonderer Kriterien, die es zu lassen einen Gästetyp zu definieren. Solche Kriterien sind die Gestik, Mimik, Körpersprache und teilweise die Kleidung eines Gastes, die eine Definition zu lassen. Damit kann der Kellner oder die Kellnerin feststellen, um welchen Gästetyp es sich handelt. Zudem wurden einige Gästetypen beschrieben, die vor allem in dem Betrieb vorkommen, in dem geforscht wurde. Insbesondere deren Ansprüche, Erwartungen und Vorlieben werden beschrieben und einer soziologischen Analyse unterzogen. Außerdem wird der touristische Hintergrund des Dorfes in Niederösterreich dargestellt, sowie ein Ausblick des Gastes in Türnitz festgehalten. Darauf lässt sich der Schluss festhalten, dass die Ansprüche des Gastes auch in ferner Zukunft weiter steigen werden. Zusätzlich verfügt die Arbeit über Bildmaterialien. Die Quellenangaben finden sich dazu in einem Abbildungsverzeichnis
ConvNets for Counting: Object Detection of Transient Phenomena in Steelpan Drums
Creators: name: Hawley, Scott H.
name: Morrison, Andrew C.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Machine Learning (cs.LG)
subject: Applied Physics (physics.app-ph)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences
subject: I.4.7

description: We train an object detector built from convolutional neural networks to count interference fringes in elliptical antinode regions in frames of high-speed video recordings of transient oscillations in Caribbean steelpan drums illuminated by electronic speckle pattern interferometry (ESPI). The annotations provided by our model aim to contribute to the understanding of time-dependent behavior in such drums by tracking the development of sympathetic vibration modes. The system is trained on a dataset of crowdsourced human-annotated images obtained from the Zooniverse Steelpan Vibrations Project. Due to the small number of human-annotated images and the ambiguity of the annotation task, we also evaluate the model on a large corpus of synthetic images whose properties have been matched to the real images by style transfer using a Generative Adversarial Network. Applying the model to thousands of unlabeled video frames, we measure oscillations consistent with audio recordings of these drum strikes. One unanticipated result is that sympathetic oscillations of higher-octave notes significantly precede the rise in sound intensity of the corresponding second harmonic tones; the mechanism responsible for this remains unidentified. This paper primarily concerns the development of the predictive model; further exploration of the steelpan images and deeper physical insights await its further application.
description: 13 pages, 9 figures, accepted for J. Acous. Soc. Am. (JASA) Special Issue on Machine Learning in Acoustics
1 Briefentwurf an den löblichen Stadtrath [von Zürich]
Brief an Zürich
Creators: name: Balber, Melchior
name: Hirzel, Heinrich
name: Horner, Johann Jakob
name: Geßner, Georg
name: Horner, Johann Caspar
name: Schinz, Johann Heinrich
name: Hess, Johann Jakob
Publisher: name: [s.n.]
Year: 1813

description: von [Melchior Balber], [Heinrich Hirzel], [Johann Jakob Horner], [Georg Geßner], [Johann Caspar Horner], [Johann Heinrich Schinz], [Johann Jakob Hess]
description: Fragment eines Entwurfs, undatiert, Jahr aus Inhalt erschlossen, Monat wahrscheinlich Februar
description: Bürgerinitiative zur Verhinderung von Nägelis geplantem Weggang nach Aarau und zum Erhalt des Singinstituts
Additional file 1 of Molecular characterisation of Pinus sylvestris (L.) in Ireland at the western limit of the species distribution
Creators: name: Belton, Samuel
name: Cubry, Philippe
name: Roche, Jenni R.
name: Kelleher, Colin T.
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1. This file contains scripts used for analysing the data
1 Briefentwurf an den löblichen Stadtrath [von Zürich]
Brief an Zürich
Creators: name: Balber, Melchior
name: Hirzel, Heinrich
name: Horner, Johann Jakob
name: Geßner, Georg
name: Horner, Johann Caspar
name: Schinz, Johann Heinrich
name: Hess, Johann Jakob
Publisher: name: [s.n.]
Year: 1813

description: von [Melchior Balber], [Heinrich Hirzel], [Johann Jakob Horner], [Georg Geßner], [Johann Caspar Horner], [Johann Heinrich Schinz], [Johann Jakob Hess]
description: Entwurf undatiert, Jahr aus Inhalt erschlossen, Monat wahrscheinlich Februar
description: Bürgerinitiative zur Verhinderung von Nägelis geplantem Weggang nach Aarau und zum Erhalt des Singinstituts
Vollmar, R., Maler
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1835

description: Ort: Bern
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
全球金融危机：国家紧急措施是否会引发国际投资争端?
Creators: Aaken, Anne van
Kurtz, Jürgen
Publisher: name: Columbia University
Year: 2009
Subjects: Finance

description: 本文评估了目前许多国家为了减轻全球金融危机的影响而采取的应对措施，并认为根据国际投资法，这些举措可能会引起赔偿责任。
title: Bestimmung der Wirkstärke von zwei neu synthetisierten Dianiliden (WHG 40 und WHG 44) an isolierten Organen von Meerschweinchen
Creators: name: Gökler, Andreas
Year: 2008

description: Im Rahmen dieser Arbeit wurden Versuchsreihen an präparierten Organen von Meerschweinchen durchgeführt. Untersucht wurden zwei neu synthetisierte Dianilide (WHG 40 und WHG 44), die strukturell Ähnlichkeiten mit dem Calciumantagonisten Diltiazem aufwiesen. Es wurde untersucht ob die beiden Testsubstanzen einen relaxierenden Effekt auf die glatte Muskulatur der Organe Aorta, Arteria pulmonalis und terminales Ileum auslösen, beziehungsweise eine negativ inotrope oder negativ chronotrope Wirkung an den Herzmuskelpräparaten Vorhof und Papillarmuskel hervorrufen. Dafür wurden die Organe in ein Organbad, in dem sich eine physiologische Nährlösung befand, eingebracht, in welches anschließend die zuvor in Lösungsmittel gelösten Testsubstanzen in verschiedenen Konzentrationen injiziert wurden. Die Apparatur war mit einem Signalverstärker verbunden, welcher die Effekte an ein externes Aufzeichnungsgerät weiterleitete, welches die Daten auf Millimeterpapier aufzeichnete. Diese Daten wurden ausgewertet und graphisch dargestellt. Die ermittelten Daten der beiden Testsubstanzen wurden miteinander in Hinblick auf relaxierende, inotrope und chronotrope Wirkung verglichen. Bezüglich der abnehmenden Kontraktion des Papillarmuskels und der Verminderung der Schlagfrequenz des Vorhofes wurden WHG 40 und WHG 44 auch mit den Calciumantagonisten Verapamil und Diltiazem verglichen. Es konnte festgestellt werden dass die Testsubstanz WHG 44 an der glatten Muskulatur eine stärkere Wirkung aufwies als die Testsubstanz WHG 40. An den Herzmuskelpräparaten erwies sich jedoch WHG 40 als die wirksamere Verbindung. Verglichen mit den beiden Calciumantagonisten zeigten beide Testsubstanzen deutlich schwächere Wirkungen.
Triponé, I. U. D., Advocat/Notar
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1835

description: Ort: Strassburg
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Zürcher, J. J. & Co
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1835

description: Ort: Cernay
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert