cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Estimated GFR Trajectories in Pediatric and Adult Nephrotic Syndrome: Results From the Nephrotic Syndrome Study Network (NEPTUNE)
Creators: name: Smith, A.R.
name: Gillespie, B.W.
name: Gibson, K.L.
name: Zee, J
name: Kretzler, M.
name: Liu, Q.
name: Mariani, L.H.
name: Troost, J.P.
name: Nair, V.
name: Ji, N.
Publisher: name: Elsevier Inc
Year: 2020

description: 56% and 16% had PNL < 10% and >50%, respectively. In both adults and pediatric patients, higher baseline eGFR was associated with higher PNL, whereas longer follow-up time was associated with lower PNL. Higher urine protein-creatinine ratio and steroid use were also associated with higher PNL in adults. Higher percentages of tubular atrophy and foot-process effacement were associated with lower and higher PNLs, respectively, in adults. Limitations: Relatively short follow-up time, inability to assess acute kidney injury events, and variable eGFR measurement frequency across patients. Conclusions: Although increasing follow-up time resulted in more linear trajectories, nonlinear eGFR trajectories were common in this cohort. Future studies in nephrotic syndrome should consider novel outcomes that do not rely on linearity assumptions.
description: Rationale & Objective: Surrogate outcomes for end-stage kidney disease often assume linear changes, which may not reflect true estimated glomerular filtration rate (eGFR) trajectories. This study's objective was to characterize nonlinear eGFR trajectories in nephrotic syndrome. Study Design: Observational cohort study. Setting & Participants: Nephrotic Syndrome Study Network (NEPTUNE) is a multicenter study of adult and pediatric patients with proteinuria enrolled at clinically indicated kidney biopsy or initial presentation of disease (pediatric only). Predictors: Patient demographic, clinical, and pathology variables at study enrollment and follow-up time. Outcome: eGFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration (patients ≥ 18 years old) or modified Chronic Kidney Disease in Children Study–Schwartz (patients < 18 years) formulas. The probability of nonlinearity (PNL) was calculated for individual eGFR trajectories. Analytical Approach: Associations between predictors and PNL were assessed using multivariable linear regression. Results: 453 patients with ≥3 eGFR measurements and 1 or more year of follow-up were included (median follow-up, 3.6 years). Median PNL was 0.052
(3662) Eileen Golbie
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Persistent Disease Activity in Patients With Long-Standing Glomerular Disease
Creators: name: Gibson, K.L.
name: Kidd, J.M.
name: Canetta, P.A.
name: Rizk, D.V.
name: Marasa, M.
name: Gharavi, A.G.
name: Wenderfer, S.E.
name: Hladunewich, M.A.
name: Delbarba, E.
name: Mu, X.
name: Nachman, P.H.
name: Julian, B.A.
name: Hogan, J.J.
name: Piva, S.E.
name: Sanghani, N.S.
name: CureGN Consortium
name: Kil, B.H.
name: Chatterjee, D.
name: Trachtman, H.
name: Rheault, M.N.
name: Bomback, A.S.
name: Laurin, L.-P.
Publisher: name: Elsevier Inc
Year: 2020

description: Introduction: Glomerular diseases are characterized by variable disease activity over many years. We aimed to analyze the relationship between clinical disease activity and duration of glomerular disease. Methods: Disease activity in adults with chronic minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and IgA nephropathy (IgAN; first diagnostic biopsy >5 years before enrollment; Of Longstanding Disease [OLD] cohort, n = 256) followed at Columbia University Medical Center (CUMC), was compared with disease activity of an internal and external cohort of patients with first diagnostic biopsy <5 years before enrollment drawn from the Cure Glomerulonephropathy Network (CureGN cohort, n = 1182; CUMC-CureGN cohort, n = 362). Disease activity was defined by (i) Kidney Disease: Improving Global Outcomes–recommended threshold criteria for initiation of immunosuppression in primary glomerulonephropathy (GN) and (ii) CureGN's Disease Activity Working Group definitions for activity. Results: No significant differences were detected among the 3 cohorts in terms of age, sex, serum creatinine, and urinary protein-to-creatinine ratio. For each GN subtype, disease activity in the OLD cohort was comparable with disease activity in the entire CureGN and the CUMC-CureGN cohort. When limiting our comparisons to disease activity in incident CUMC-CureGN patients (first diagnostic biopsy within 6 months of enrollment), OLD patients demonstrated similar activity rates as incident patients. Conclusion: Disease activity did not differ among patients with shorter versus longer duration of disease. Such survivor patients, with long-term but persistent disease, are potentially highly informative for understanding the clinical course and pathogenesis of GN and may help identify factors mediating more chronic subtypes of disease.
Urinary Epidermal Growth Factor as a Marker of Disease Progression in Children With Nephrotic Syndrome
Creators: name: Lemley, K.V.
name: Trachtman, H.
name: Sampson, M.G.
name: Troost, J.P.
name: Dell, K.M.
name: Brown, E.
name: Gibson, K.L.
name: Yee, J.L.
name: Kretzler, M.
name: Gillespie, B.W.
name: Lin, J.-J.
name: Neu, A.M.
name: Tran, C.L.
name: Meyers, K.E.
name: Sethna, C.B.
name: Wang, C.-S.
name: Oh, G.
name: Kaskel, F.J.
name: Hingorani, S.
name: Roth, T.M.
name: Greenbaum, L.A.
name: Gipson, D.S.
name: Eddy, S.
name: Ju, W.
name: Reidy, K.J.
name: Srivastava, T.
name: Tuttle, K.R.
name: Waldo, A.
Publisher: name: Elsevier Inc
Year: 2020

description: Introduction: Childhood-onset nephrotic syndrome has a variable clinical course. Improved predictive markers of long-term outcomes in children with nephrotic syndrome are needed. This study tests the association between baseline urinary epidermal growth factor (uEGF) excretion and longitudinal kidney function in children with nephrotic syndrome. Methods: The study evaluated 191 participants younger than 18 years enrolled in the Nephrotic Syndrome Study Network, including 118 with their first clinically indicated kidney biopsy (68 minimal change disease; 50 focal segmental glomerulosclerosis) and 73 with incident nephrotic syndrome without a biopsy. uEGF was measured at baseline for all participants and normalized by the urine creatinine (Cr) concentration. Renal epidermal growth factor (EGF) mRNA was measured in the tubular compartment microdissected from kidney biopsy cores from a subset of patients. Linear mixed models were used to test if baseline uEGF/Cr and EGF mRNA expression were associated with change in estimated glomerular filtration rate (eGFR) over time. Results: Higher uEGF/Cr at baseline was associated with slower eGFR decline during follow-up (median follow-up = 30 months). Halving of uEGF/Cr was associated with a decrease in eGFR slope of 2.0 ml/min per 1.73 m2 per year (P < 0.001) adjusted for age, race, diagnosis, baseline eGFR and proteinuria, and APOL1 genotype. In the biopsied subgroup, uEGF/Cr was correlated with EGF mRNA expression (r = 0.74; P < 0.001), but uEGF/Cr was retained over mRNA expression as the stronger predictor of eGFR slope after multivariable adjustment (decrease in eGFR slope of 1.7 ml/min per 1.73 m2 per year per log2 decrease in uEGF/Cr; P < 0.001). Conclusion: uEGF/Cr may be a useful noninvasive biomarker that can assist in predicting the long-term course of kidney function in children with incident nephrotic syndrome.
Mid-IR and VUV Spectroscopic Characterisation of Thermally Processed and Electron Irradiated CO2 Astrophysical Ice Analogues
Creators: name: Mifsud, DV
name: Kaňuchová, Z
name: Ioppolo, S
name: Herczku, P
name: Muiña, A Traspas
name: Field, TA
name: Hailey, PA
name: Juhász, Z
name: Kovács, STS
name: Mason, NJ
name: McCullough, RW
name: Pavithraa, S
name: Rahul, KK
name: Paripás, B
name: Sulik, B
name: Chou, SL
name: Lo, JI
name: Das, A
name: Cheng, BM
name: Rajasekhar, BN
name: Bhardwaj, A
name: Sivaraman, B
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Chemical Physics (physics.chem-ph)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: The astrochemistry of CO2 ice analogues has been a topic of intensive investigation due to the prevalence of CO2 throughout the interstellar medium and the Solar System, as well as the possibility of it acting as a carbon feedstock for the synthesis of larger, more complex organic molecules. In order to accurately discern the physico-chemical processes in which CO2 plays a role, it is necessary to have laboratory-generated spectra to compare against observational data acquired by ground- and space-based telescopes. A key factor which is known to influence the appearance of such spectra is temperature, especially when the spectra are acquired in the infrared and ultraviolet. In this present study, we describe the results of a systematic investigation looking into: (i) the influence of thermal annealing on the mid-IR and VUV absorption spectra of pure, unirradiated CO2 astrophysical ice analogues prepared at various temperatures, and (ii) the influence of temperature on the chemical products of electron irradiation of similar ices. Our results indicate that both mid-IR and VUV spectra of pure CO2 ices are sensitive to the structural and chemical changes induced by thermal annealing. Furthermore, using mid-IR spectroscopy, we have successfully identified the production of radiolytic daughter molecules as a result of 1 keV electron irradiation and the influence of temperature over this chemistry. Such results are directly applicable to studies on the chemistry of interstellar ices, comets, and icy lunar objects and may also be useful as reference data for forthcoming observational missions.
description: Published in the 'Journal of Molecular Spectroscopy'. Includes 40 pages, 7 figures, 2 tables, and a graphical abstract
L2 Lower Sorbian
Creators: name: Howson, Phil J.
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Linguistics
subject: FOS: Languages and literature
subject: Arts and Humanities
subject: Language Description and Documentation
subject: First and Second Language Acquisition
subject: Social and Behavioral Sciences
subject: Other Linguistics
subject: Phonetics and Phonology
subject: Ultrasound
subject: phonetics
subject: Language Acquisition
subject: Lower Sorbian
subject: L2 Acquisition
subject: Second Language Acquisition

description: Tongue coordinates extracted from ultrasound data collection for L2 learners of Lower Sorbian. It includes participant information and extended data for Howson (2023).
Microscopic analysis of the magnetic form factor in low-dimensional cuprates
Creators: name: Mazurenko, V. V.
name: Solovyev, I. V.
name: Tsirlin, A. A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We analyze the magnetic form factor of Cu$^{2+}$ in low-dimensional quantum magnets by taking the metal-ligand hybridization into account explicitly. In this analysis we use the form of magnetic Wannier orbitals, derived from the first-principles calculations, and identify the contributions of different atomic sites. Having performed local density approximation calculations for cuprates with different types of ligand atoms, we discuss the influence of the on-site Coulomb correlations on the structure of the magnetic orbital. The typical composition of Wannier functions for copper oxides, chlorides and bromides is defined and related to features of the magnetic form factor. We propose easy-to-use approximations of the partial orbital contributions to the magnetic form factor in order to give a microscopic explanation for the results obtained in previous first-principles studies.
description: 5 pages, 4 figures
Symmetry in abstract elementary classes with amalgamation
Creators: name: VanDieren, Monica M.
name: Vasey, Sebastien
Publisher: name: arXiv
Year: 2015
Subjects: subject: Logic (math.LO)
subject: FOS: Mathematics
subject: 03C48 (Primary), 03C45, 03C52, 03C55 (Secondary)

description: This paper is part of a program initiated by Saharon Shelah to extend the model theory of first order logic to the non-elementary setting of abstract elementary classes (AECs). An abstract elementary class is a semantic generalization of the class of models of a complete first order theory with the elementary substructure relation. We examine the symmetry property of splitting (previously isolated by the first author) in AECs with amalgamation that satisfy a local definition of superstability. The key results are a downward transfer of symmetry and a deduction of symmetry from failure of the order property. These results are then used to prove several structural properties in categorical AECs, improving classical results of Shelah who focused on the special case of categoricity in a successor cardinal. We also study the interaction of symmetry with tameness, a locality property for Galois (orbital) types. We show that superstability and tameness together imply symmetry. This sharpens previous work of Boney and the second author.
description: 37 pages. This merges with arXiv:1509.01488 . Was previously titled "Transferring symmetry downward and applications"
(3656) Mary Helen Margaret Cook
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(3657) Storr Hodson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
L'entrepreneuriat féminin au Maroc : Un vivier d'opportunités pour une croissance économique inclusive
Creators: name: MABCHOUR Asmaa
name: DABNICHI Youness
Publisher: name: Zenodo
Year: 2024

description: L'effet de l'approche genre sur le développement économique, particulièrement dans le cas du Maroc, représente une dynamique complexe entre l'égalité des sexes et la croissance économique. En adoptant des politiques et des stratégies axées sur l'inclusion des femmes dans tous les secteurs, le Maroc vise à maximiser le potentiel économique de l'ensemble de sa population. L'accent mis sur l'autonomisation des femmes à travers l'éducation, la santé reproductive et l'accès équitable aux opportunités professionnelles contribue à créer un environnement propice à une croissance économique durable et inclusive. La réduction des disparités de genre peut générer un "dividende démographique", améliorer la productivité et stimuler l'innovation. Cependant, la réalisation de ces objectifs nécessite une mise en œuvre efficace des politiques et un changement culturel pour promouvoir l'égalité des sexes comme un moteur essentiel du développement économique au Maroc. Fort des résultats de cette étude, il apparaît que le Maroc a établi un cadre stratégique solide pour propulser les femmes marocaines en tant qu'actrices clés du développement du pays. Ainsi une corrélation positive à long terme est observée entre l'entrepreneuriat adoptant une approche genre et la croissance économique.
Additional file 2 of Associations between change in labour market policies and work stressors: a comparative longitudinal survey data analysis from 27 European countries
Creators: name: Lunau, T.
name: M. Wahrendorf
name: N. Dragano
name: J. Siegrist
name: K. A. Van Der Wel
name: M. Rigó
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Additional file 2 : Policy indicators.
The american pediatric society and society for pediatric research joint statement against racism and social injustice
Creators: name: Simon, T.
name: Glass, H.
name: Maitre, N.
name: Baker, S.
name: Davis, S.
name: Goyal, M.
name: Shah, P.
name: Gordon, C.M.
name: Frazer, L.
name: Orange, J.
name: Steinhorn, R.H.
name: Fike, C.
name: Armstrong, S.
name: Walker-Harding, L.R.
name: Abman, S.H.
name: Debaun, M.R.
name: Holtz, L.
name: Chalak, L.
name: Hirschhorn, J.
name: Bogue, C.W.
name: McAllister-Lucas, L.
name: Gibson, K.
name: Leonard, M.B.
name: Carlo, W.
name: Tarini, B.
name: Markham, L.
name: Daniels, S.R.
name: Hunstad, D.
name: Gill, M.
Publisher: name: Springer Nature
Year: 2020

description: Although the coronavirus disease 2019 pandemic has served as a flashlight, illuminating and unmasking deep socio-economic and health care divides in our country, the terrible events surrounding the horrific murder of Mr. George Floyd in Minneapolis has spawned even greater outrage. As we all know, Mr. Floyd’s death is not an isolated incident, as there have been a tragic string of such deaths in recent years that further reflect deep issues regarding racism and systemic underlying causes of injustice. Unfortunately, the country’s inability to fully address these systemic foundations of injustice persists.
Entanglement dynamics in quantum many-body systems
Creators: name: Ho, Wen Wei
name: Abanin, Dmitry A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Theory (hep-th)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The dynamics of entanglement has recently been realized as a useful probe in studying ergodicity and its breakdown in quantum many-body systems. In this paper, we study theoretically the growth of entanglement in quantum many-body systems and propose a method to measure it experimentally. We show that entanglement growth is related to the spreading of local operators in real space. We present a simple toy model for ergodic systems in which linear spreading of operators results in a universal, linear in time growth of entanglement for initial product states, in contrast with the logarithmic growth of entanglement in many-body localized (MBL) systems. Furthermore, we show that entanglement growth is directly related to the decay of the Loschmidt echo in a composite system comprised of several copies of the original system, in which connections are controlled by a quantum switch (two-level system). By measuring only the switch's dynamics, the growth of the Rényi entropies can be extracted. Our work provides a way of understanding entanglement dynamics in many-body systems, and to directly measure its growth in time via a single local measurement.
description: 5 + 4 pages, 2 figures
(3658) Gwendolen Sallitt
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Position-squared coupling in a tunable photonic crystal optomechanical cavity
Creators: name: Paraiso, Taofiq K.
name: Kalaee, Mahmoud
name: Zang, Leyun
name: Pfeifer, Hannes
name: Marquardt, Florian
name: Painter, Oskar
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present the design, fabrication, and characterization of a planar silicon photonic crystal cavity in which large position-squared optomechanical coupling is realized. The device consists of a double-slotted photonic crystal structure in which motion of a central beam mode couples to two high-Q optical modes localized around each slot. Electrostatic tuning of the structure is used to controllably hybridize the optical modes into supermodes which couple in a quadratic fashion to the motion of the beam. From independent measurements of the anti-crossing of the optical modes and of the optical spring effect, the position-squared vacuum coupling rate is measured to be as large as 245 Hz to the fundamental in-plane mechanical resonance of the structure at 8.7MHz, which in displacement units corresponds to a coupling coefficient of 1 THz/nm$^2$. This level of position-squared coupling is approximately five orders of magnitude larger than in conventional Fabry-Perot cavity systems.
description: 11 pages, 6 figures
(3654) J. B. Coates
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Treatment Patterns Among Adults and Children With Membranous Nephropathy in the Cure Glomerulonephropathy Network (CureGN)
Creators: name: Al-Uzri, A.
name: Rheault, M.N.
name: Laurin, L.-P.
name: Sanghani, N.S.
name: Kogon, A.J.
name: Wang, C.-S.
name: Parsa, A.
name: Hladunewich, M.A.
name: Ashoor, I.F.
name: Gibson, K.L.
name: Matar, R.B.
name: Selewski, D.T.
name: Troost, J.P.
name: Khalid, M.
name: Guay-Woodford, L.
name: Gillespie, B.W.
name: Srivastava, T.
name: Bomback, A.S.
name: Gipson, D.S.
name: O'Shaughnessy, M.M.
name: Vento, S.
Publisher: name: Elsevier Inc
Year: 2019

description: Introduction: The 2012 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guidelines for Glomerulonephritis recommend that patients with membranous nephropathy (MN) at risk for progression receive immunosuppressive therapy (IST), usually after 6 months of observation. A cyclophosphamide (CYC) or calcineurin inhibitor (CNI)–based regimen is recommended as first-line IST. However, the extent to which KDIGO recommendations are adopted in practice remains largely unknown. Methods: We evaluated prescribing practice among patients with primary MN (diagnosed 2010–2018) enrolled in the Cure Glomerulonephropathy Network (CureGN) cohort study. We also evaluated the availability of testing for phospholipase A2 receptor (PLA2R) in the contemporary era. Results: Among 361 patients (324 adults and 37 children) with MN who were IST-naïve at biopsy and had at least 6 months of follow-up, 55% of adults and 58% of children initiated IST <6 months after biopsy. Of these, 1 in 5 had no indication for (i.e., urine protein-to-creatinine ratio [uPCR] <4 g/g) or an apparent contraindication to (i.e., an estimated glomerular filtration rate [eGFR] <30 ml/min per 1.73 m2) IST. As first-line IST, half of treated patients received either CYC (16% of adults; 0% of children) or a CNI (40% and 46%, respectively), whereas 1 in 5 received corticosteroid monotherapy (20% and 27%, respectively) and 1 in 6 rituximab (15% and 15%, respectively). More than 80% of surveyed centers had access to PLA2R testing. Conclusion: These findings suggest that providers are not aware of, or lack confidence in, current KDIGO guidelines for MN. Treatment patterns observed in this cohort might critically inform the drafting of planned updates to KDIGO guidelines.
Additional file 1 of Beliefs, attitude, and knowledge of the Iranian physiatrists towards neuromusculoskeletal ultrasound and common barriers in its application
Creators: name: Khodadadi, Leyla
name: Karimzade, Afshin
name: Rayegani, Seyed Mansoor
name: Nafisseh Jafarian
name: Raeissadat, Seyed Ahmad
name: Yasrebi, Sina
name: Babaei-Ghazani, Arash
name: Eftekharsadat, Bina
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Additional file 1. The questionnaire developed and used for data collection in this study; English version.
Text Messaging for Disease Monitoring in Childhood Nephrotic Syndrome
Creators: name: Reidy, K.
name: Tran, C.L.
name: Gipson, D.S.
name: Meyers, K.
name: Troost, J.P.
name: Piette, J.D.
name: Kallem, K.
name: Vento, S.
name: Lin, J.-J.
name: Gibson, K.
name: Greenbaum, L.A.
name: Wang, C.-S.
name: Hingorani, S.
name: Dell, K.M.
name: Herreshoff, E.
name: Lemley, K.
name: Oh, G.
name: Sethna, C.B.
name: Trachtman, H.
name: Srivastava, T.
name: Brown, E.
name: Kaskel, F.
Publisher: name: Elsevier Inc
Year: 2019

description: Introduction: There is limited information on effective disease monitoring for prompt interventions in childhood nephrotic syndrome. We examined the feasibility and effectiveness of a novel text messaging system (SMS) for disease monitoring in a multicenter, prospective study. Methods: A total of 127 patients <19 years with incident nephrotic syndrome were enrolled in the ongoing Nephrotic Syndrome Study Network between June 2015 and March 2018. Text messages soliciting home urine protein results, symptoms, and medication adherence were sent to a designated caregiver (n = 116) or adolescent patient (n = 3). Participants responded by texting. Feasibility of SMS was assessed by SMS adoption, retention, and engagement, and concordance between participant-reported results and laboratory/clinician assessments. The number of disease relapses and time-to-remission data captured by SMS were compared with data collected by conventional visits. Results: A total of 119 of 127 (94%) patients agreed to SMS monitoring. Retention rate was 94%, with a median follow-up of 360 days (interquartile range [IQR] 353–362). Overall engagement was high, with a median response rate of 87% (IQR, 68–97). Concordance between SMS-captured home urine protein results and edema status with same-day in-person study visit was excellent (kappa values 0.88 and 0.92, respectively). SMS detected a total of 108 relapse events compared with 41 events captured by scheduled visits. Median time to remission after enrollment was 22 days as captured by SMS versus 50 days as captured by scheduled visits. Conclusion: SMS was well accepted by caregivers and adolescent patients and reliably captured nephrotic syndrome disease activity between clinic visits. Additional studies are needed to explore the impact of SMS on disease outcomes.
Finding that needle in the haystack: Computable phenotypes
Creators: name: Gibson, K.L.
name: Glenn, D.
Publisher: name: American Society of Nephrology
Year: 2019

description: In a 1532 publication, Sir Thomas More—an English lawyer and social philosopher—likened one’s ability to find a line in St. Austin’s writing to finding a needle in a meadow—later interpreted as a “needle in the haystack.” The isolation experienced by patients with rare diseases can often make them feel like lost needles in the meadow of our large complex health care systems. As of 2018, there were 327.2 million people with the potential to have data stored across 5534 registered hospitals in the United States alone along with over 1100 different electronic health record vendors. The frustration experienced by those eager to connect individuals with rare diseases to clinical care and research opportunities is magnified by the fact that our electronic medical record systems at times fall short of “meaningful use” and do many things to the exception of connecting to other systems and providing efficient communication. The effect that this complicated meadow has on clinical care has been well described, but the barriers that this poses to patient recruitment into clinical and other research trials are less addressed in published literature.
Pengaruh Kepercayaan Diri Terhadap Body Dissatisfaction Pada Remaja Putri di SMA X
Creators: name: Yosa Afriany, Rijal Abdillah
Publisher: name: Zenodo
Year: 2024

description: Perkembangan fisik akan berkembang sangat cepat dan signifikan pada masa remaja dan hal ini sangat identik dengan masa pubertas. Tak heran jika pada fase ini remaja putri menjadi jauh lebih sensitif terhadap penampilan fisiknya karena terdapat banyak sekali perubahan pada dirinya. Dari ketidakpuasan inilah yang pada akhirnya mendorong remaja putri untuk terus menerus memperbaiki penampilan fisiknya. Timbulnya perasaan tersebut dikarenakan remaja putri menemukan bahwa dirinya tidak selaras dengan standar masyarakat hingga merasa tidak percaya diri.Penelitian ini merupakan penelitian kuantitatif korelasional yang bertujuan untuk mengetahui pengaruh kepercayaan diri terhadap body dissatisfaction pada remaja putri di SMA X. Teknik pengambilan sampel yang digunakan adalah cluster random sampling dengan sampel penelitian sebanyak 238 siswi. Metode analisis yang digunakan yaitu analisis regresi linier sederhana dan hasil analisis menunjukkan bahwa terdapat pengaruh kepercayaan diri terhadap body dissatisfaction pada remaja putri di SMA X. Kepercayaan diri memberikan sumbangan pengaruh sebesar 17,7% terhadap body dissatisfaction. Lalu, hasil kategorisasi kepercayaan diri dan body dissatisfaction pada remaja putri di SMA X, mayoritas berada pada kategori sedang.
Labomimus maolan Zhang, Li & Yin 2019
Creators: name: Yin, Zi-Wei
name: Li, Ning
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Staphylinidae
Labomimus
Labomimus maolan

description: Labomimus maolan Zhang, Li & Yin, 2019 Labomimus maolan Zhang, Li & Yin, 2019: 513 Type locality. China: Guizhou, Libo County, Maolan N. R., Dongdai, 25°17′13″N, 107°56′23″E, 792 m. Additional material examined (1 specimen). VIETNAM: LÀO CAI: 1 ♂, ‘VIETNAMN, 22°20′N, 103°50′E, SAPA (Lao Cai), 25.5- 10.6.1991, leg. E. Jendek’ (VBGG). Comments. Labomimus maolan was originally described from Guizhou, southwestern China, and is here newly record from Lào Cai, northern Vietnam. The population from Vietnam slightly differs from that from China in the shape of the apical portion of the aedeagal median lobe, and in endophallus; otherwise, the form of the antennal clubs and the leg spination are identical. Distribution. China: Guizhou; Vietnam: Lào Cai (ZH AN G et al. 2019; this paper). First country record for Vietnam.
description: Published as part of Yin, Zi-Wei & Li, Ning, 2021, Eight new species and additional records of the Pselaphodes complex from Laos and Vietnam, with a key to known species (Coleoptera: Staphylinidae: Pselaphinae), pp. 35-53 in Acta Entomologica Musei Nationalis Pragae (Acta. Ent. Mus. Natl. Pragae) (Acta. Ent. Mus. Natl. Pragae) 61 (1) on page 39, DOI: 10.37520/aemnp.2021.002, http://zenodo.org/record/5037464
description: {"references": ["ZHANG Y. - Q., LI L. - Z. & YIN Z. - W. 2019: Fifteen new species and a new country record of Labomimus Sharp from China, with a checklist of world species (Coleoptera: Staphylinidae: Pselaphinae). Zootaxa 4554 (2): 497 - 531."]}
Recurrence of nephrotic syndrome following kidney transplantation is associated with initial native kidney biopsy findings
Creators: name: Rheault, M.N.
name: Jawa, N.
name: Weng, P.
name: Kallash, M.
name: Foreman, J.W.
name: Selewski, D.
name: Srivastava, T.
name: Brewer, E.D.
name: Pelletier, J.H.
name: Kumar, K.R.
name: Gibson, K.
name: Chambers, E.
name: Wenderfer, S.E.
name: Bensimhon, A.
name: Davis, T.K.
name: Engen, R.
name: Greenbaum, L.A.
name: Chua, A.N.
name: Nagaraj, S.K.
name: Gbadegesin, R.A.
name: Varner, J.D.
name: Straatmann, C.
name: Silva, C.
name: Wigfall, D.R.
name: Licht, C.
name: Hornik, C.P.
name: Barcia, J.
Publisher: name: Springer Verlag
Year: 2018

description: Background and objectives: Steroid-resistant nephrotic syndrome (SRNS) due to focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD) is a leading cause of end-stage kidney disease in children. Recurrence of primary disease following transplantation is a major cause of allograft loss. The clinical determinants of disease recurrence are not completely known. Our objectives were to determine risk factors for recurrence of FSGS/MCD following kidney transplantation and factors that predict response to immunosuppression following recurrence. Methods: Multicenter study of pediatric patients with kidney transplants performed for ESKD due to SRNS between 1/2006 and 12/2015. Demographics, clinical course, and biopsy data were collected. Patients with primary-SRNS (PSRNS) were defined as those initially resistant to corticosteroid therapy at diagnosis, and patients with late-SRNS (LSRNS) as those initially responsive to steroids who subsequently developed steroid resistance. We performed logistic regression to determine risk factors associated with nephrotic syndrome (NS) recurrence. Results: We analyzed 158 patients; 64 (41%) had recurrence of NS in their renal allograft. Disease recurrence occurred in 78% of patients with LSRNS compared to 39% of those with PSRNS. Patients with MCD on initial native kidney biopsy had a 76% recurrence rate compared with a 40% recurrence rate in those with FSGS. Multivariable analysis showed that MCD histology (OR; 95% CI 5.6; 1.3–23.7) compared to FSGS predicted disease recurrence. Conclusions: Pediatric patients with MCD and LSRNS are at higher risk of disease recurrence following kidney transplantation. These findings may be useful for designing studies to test strategies for preventing recurrence.
Renormalization of dimension 6 gluon operators
Creators: name: Kim, HyungJoo
name: Lee, Su Houng
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We identify the independent dimension 6 twist 4 gluon operators and calculate their renormalization in the pure gauge theory. By constructing the renormalization group invariant combinations, we find the scale invariant condensates that can be estimated in nonperturbative calculations and used in QCD sum rules for heavy quark systems in medium.
description: 4 pages, 2 figures
Blood Pressure and Visit-to-Visit Blood Pressure Variability among Individuals with Primary Proteinuric Glomerulopathies
Creators: name: Meyers, K.E.C.
name: Kretzler, M.
name: Brady, T.M.
name: Gibson, K.L.
name: Gadegbeku, C.A.
name: Mariani, L.H., Baltimore, MD, United States
name: Sethna, C.B.
name: Psoter, K.J.
name: Srivastava, T.
Publisher: name: Lippincott Williams and Wilkins
Year: 2017

description: Hypertension and blood pressure variability (BPV; SD and average real variability) in primary proteinuric glomerulopathies are not well described. Data were from 433 participants in the NEPTUNE (Nephrotic Syndrome Study Network). Hypertensive BP status was defined as previous history of hypertension or BP ≥140/90 mm Hg for adults/≥95th percentile for children at baseline. BPV was measured in participants with ≥3 visits in the first year. Two-hundred ninety-six adults (43 years [interquartile range, 32-57.8 years], 61.5% male) and 147 children (11 years [interquartile range, 5-14 years], 57.8% male) were evaluated. At baseline, 64.8% of adults and 46.9% of children were hypertensive. Histological diagnosis was associated with hypertensive status in adults (P=0.036). In adults, hypertensive status was associated with lower hazard of complete remission (hazard ratio, 0.36; 95% confidence interval, 0.19-0.68) and greater hazard of achieving the composite end point (end-stage renal disease or estimated glomerular filtration rate decline >40%; hazard ratio, 4.1; 95% confidence interval, 1.4-12). Greater systolic and diastolic SD and average real variability were also associated with greater hazard of reaching the composite end point in adults (all P<0.01). In children, greater BPV was an independent predictor of composite end point (determined by systolic SD and average real variability) and complete remission (determined by systolic and diastolic average real variability; all P<0.05). Hypertensive status was common among adults and children enrolled in NEPTUNE. Differences in hypertensive status prevalence, BPV, and treatment were found by age and histological diagnosis. In addition, hypertensive status and greater BPV were associated with poorer clinical outcomes.
Additional file 1 of WRN modulates translation by influencing nuclear mRNA export in HeLa cancer cells
Creators: name: Iglesias-Pedraz, Juan Manuel
name: Fossatti-Jara, Diego Matia
name: Valle-Riestra-Felice, Valeria
name: Cruz-Visalaya, Sergio Rafael
name: Felix, Jose Antonio Ayala
name: Comai, Lucio
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Computational Biology

description: Additional file 1. Original images. Original uncropped images used to generate the figures shown in the manuscript.
C4d-expressing glomerulopathy and proteinuria post transplantation of a too-big-for-size mismatched kidney allograft: An unusual case with good outcome
Creators: name: Kozlowski, T.
name: Nickeleit, V.
name: Gougeon, F.
name: Mikhailov, A.V.
name: Gibson, K.
name: Singh, H.K.
Publisher: name: Dustri-Verlag Dr. Karl Feistle
Year: 2017

description: A 5-year-old severely growthretarded child with tubulointerstitial, oliguric end-stage renal disease received an adult-size kidney transplant. Three years post grafting under standard triple immunosuppression (mycophenolate mofetil, tacrolimus, and prednisone) de novo nephrotic range proteinuria without the nephrotic syndrome developed. Graft function was normal (serum creatinine: 0.2 - 0.3 mg/dL), there were no donor-specific HLA antibodies (DSA), and the urine sediment was inactive. Two biopsies collected 3 and 4 years post-transplantation showed severe glomerular capillary wall remodeling and associated pseudolinear C4d staining as morphologic correlates for the proteinuria. Changes resembled those seen in so-called "size-mismatch transplant glomerulopathies". There was no evidence of a glomerulonephritis, acute or chronic rejection including transplant glomerulopathy, interstitial fibrosis, peritubular capillary C4d deposits, or multilamination of peritubular capillary basement membranes. The glomerular changes were not detected in the implantation zero-hour biopsy or the recipient's native renal biopsy. At the end of follow-up 64 months post transplantation, proteinuria persisted at subnephrotic levels in the setting of stable graft function and undetectable DSAs. This unique case adds to the list of causes of nonrejection-associated post-transplant proteinuria. It demonstrates for the first time that a too-large-for-body-size mismatched graft is associated with a presumably sheer stressinduced C4d expressing glomerulopathy, severe proteinuria, and favorable outcome.
(3651) Geoffrey Copson Peake
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
MHD Seismology of a loop-like filament tube by observed kink waves
Creators: name: Pant, V.
name: Srivastava, A. K.
name: Banerjee, D.
name: Goossens, M.
name: Chen, P. F.
name: Joshi, N. C.
name: Zhou, Y. H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We report and analyze the observational evidence of global kink oscillations in a solar filament as observed in H alpha by National Solar Observatory (NSO)/Global Oscillation Network Group (GONG) instrument. An M1.1-class flare in active region 11692 on 2013 March 15 induced a global kink mode in the filament lying in the south-west of AR11692.We find periods of about 61 - 67 minutes and damping times of 92 - 117 minutes at three vertical slice positions chosen in and around the filament apex. We find that the waves are damped. From the observed global kink mode period and damping time scale using the theory of resonant absorption we perform prominence seismology. We estimate a lower cut-off value for the inhomogeneity length-scale to be around 0.34 - 0.44 times the radius of the filament cross-section.
description: 3 figures, Accepted for publication in RAA
Statistical Constraints on the Error of the Leptonic CP Violation of Neutrinos
Creators: name: Fu, Kai
name: Zhang, Ying
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: A constraint on the error of leptonic CP violation, which require the phase $δ_{CP}$ to be less than $π/4$ for it to be distinguishable on a $2π$ cycle, is presented. Under this constraint, the effects of neutrino detector 's distance, beam energy, and energy resolution are discussed with reference to the present values of these parameters in experiments. Although an optimized detector performances can minimize the deviation to yield a larger distinguishable range of the leptonic CP phase on a $2π$ cycle, it is not possible to determine an arbitrary leptonic CP phase in the range of $2π$ with the statistics from a single detector because of the existence of two singular points. An efficiency factor $η$ is defined to characterize the distinguishable range of $δ_{CP}$. To cover the entire possible $δ_{CP}$ range, a combined efficiency factor $η^*$ corresponding to multiple sets of detection parameters with different neutrino beam energies and distances is proposed. The combined efficiency factors $η^*$ of various major experiments are also presented.
description: 9 pages, 5 figures
Additional file 5 of WRN modulates translation by influencing nuclear mRNA export in HeLa cancer cells
Creators: name: Iglesias-Pedraz, Juan Manuel
name: Fossatti-Jara, Diego Matia
name: Valle-Riestra-Felice, Valeria
name: Cruz-Visalaya, Sergio Rafael
name: Felix, Jose Antonio Ayala
name: Comai, Lucio
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Computational Biology

description: Additional file 5: Supplementary Table 1. List of the primary and secondary antibodies used in this study.
Hemodialysis outcomes in a global sample of children and young adult hemodialysis patients: The PICCOLO MONDO cohort
Creators: name: Xu, X.
name: Picoits-Filho, R.
name: Kooman, J.P.
name: Gibson, K.
name: Xiao, Q.
name: Usvyat, L.
name: Ferris, M.
name: Von Gersdorff, G.
name: Carioni, P.
name: Plattner, B.
name: Westreich, K.
name: Kotanko, P.
name: Sylvestre, L.
name: Marelli, C.
name: Van Der Sande, F.M.
name: Gipson, D.S.
name: Power, A.
name: Marcelli, D.
name: Etter, M.
Publisher: name: Oxford University Press
Year: 2016

description: Background The aim of this study was to describe the experience of pediatric and young adult hemodialysis (HD) patients from a global cohort. Methods The Pediatric Investigation and Close Collaborative Consortium for Ongoing Life Outcomes for MONitoring Dialysis Outcomes (PICCOLO MONDO) study provided de-identified electronic information of 3244 patients, ages 0-30 years from 2000 to 2012 in four regions: Asia, Europe, North America and South America. The study sample was categorized into pediatric (≤18 years old) and young adult (19-30 years old) groups based on the age at dialysis initiation. Results For those with known end-stage renal disease etiology, glomerular disease was the most common diagnosis in children and young adults. Using Europe as a reference group, North America [odds ratio (OR) 2.69; CI 1.29, 5.63] and South America (OR 4.21; CI 2.32, 7.63) had the greatest mortality among young adults. North America also had higher rates of overweight, obesity, hypertension, cardiovascular disease, hospitalizations and secondary diabetes compared with all other regions. Initial catheter use was greater for North American (86.4% in pediatric patients and 75.2% in young adults) and South America (80.6% in pediatric patients and 75.9% in young adults). Catheter use at 1-year follow-up was most common in North American children (77.3%) and young adults (62.9%). Asia had the lowest rate of catheter use. For both age groups, dialysis adequacy (equilibrated Kt/V) ranged between 1.4 and 1.5. In Asia, patients in both age groups had significantly longer treatment times than in any other region. Conclusions The PICCOLO MONDO study has provided unique baseline and 1-year follow-up information on children and young adults receiving HD around the globe. This cohort has brought to light aspects of care in these age groups that warrant further investigation.