Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis
Creators: name: Gao, Yixin
name: Wang, Ting
name: Yu, Xinghao
name: Zhao, Huashuo
name: Zeng, Ping
name: Ferrari, Raffaele
name: Hernandez, Dena G.
name: Nalls, Michael A.
name: Rohrer, Jonathan D.
name: Ramasamy, Adaikalavan
name: Kwok, John B. J.
name: Dobson-Stone, Carol
name: Brooks, William S.
name: Schofield, Peter R.
name: Halliday, Glenda M.
name: Hodges, John R.
name: Piguet, Olivier
name: Bartley, Lauren
name: Thompson, Elizabeth
name: Haan, Eric
name: Hernández, Isabel
name: Ruiz, Agustín
name: Boada, Mercè
name: Borroni, Barbara
name: Padovani, Alessandro
name: Cruchaga, Carlos
name: Cairns, Nigel J.
name: Benussi, Luisa
name: Binetti, Giuliano
name: Ghidoni, Roberta
name: Forloni, Gianluigi
name: Albani, Diego
name: Galimberti, Daniela
name: Fenoglio, Chiara
name: Serpente, Maria
name: Scarpini, Elio
name: Clarimón, Jordi
name: Lleó, Alberto
name: Blesa, Rafael
name: Waldö, Maria Landqvist
name: Nilsson, Karin
name: Nilsson, Christer
name: Mackenzie, Ian R. A.
name: Hsiung, Ging-Yuek R.
name: Mann, David M. A.
name: Grafman, Jordan
name: Morris, Christopher M.
name: Attems, Johannes
name: Griffiths, Timothy D.
name: McKeith, Ian G.
name: Thomas, Alan J.
name: Pietrini, Pietro
name: Huey, Edward D.
name: Wassermann, Eric M.
name: Baborie, Atik
name: Jaros, Evelyn
name: Tierney, Michael C.
name: Pastor, Pau
name: Razquin, Cristina
name: Ortega-Cubero, Sara
name: Alonso, Elena
name: Perneczky, Robert
name: Diehl-Schmid, Janine
name: Alexopoulos, Panagiotis
name: Kurz, Alexander
name: Rainero, Innocenzo
name: Rubino, Elisa
name: Pinessi, Lorenzo
name: Rogaeva, Ekaterina
name: George-Hyslop, Peter St
name: Rossi, Giacomina
name: Tagliavini, Fabrizio
name: Giaccone, Giorgio
name: Rowe, James B.
name: Schlachetzki, Johannes C. M.
name: Uphill, James
name: Collinge, John
name: Mead, Simon
name: Danek, Adrian
name: Van Deerlin, Vivianna M.
name: Grossman, Murray
name: Trojanowski, John Q.
name: Van Der Zee, Julie
name: Cruts, Marc
name: Van Broeckhoven, Christine
name: Cappa, Stefano F.
name: Leber, Isabelle
name: Hannequin, Didier
name: Golfier, Véronique
name: Vercelletto, Martine
name: Brice, Alexis
name: Nacmias, Benedetta
name: Sorbi, Sandro
name: Bagnoli, Silvia
name: Piaceri, Irene
name: Nielsen, Jørgen E.
name: Hjermind, Lena E.
name: Riemenschneider, Matthias
name: Mayhaus, Manuel
name: Ibach, Bernd
name: Gasparoni, Gilles
name: Pichler, Sabrina
name: Gu, Wei
name: Rossor, Martin N.
name: Fox, Nick C.
name: Warren, Jason D.
name: Spillantini, Maria Grazia
name: Morris, Huw R.
name: Rizzu, Patrizia
name: Heutink, Peter
name: Snowden, Julie S.
name: Rollinson, Sara
name: Richardson, Anna
name: Gerhard, Alexander
name: Bruni, Amalia C.
name: Maletta, Raffaele
name: Frangipane, Francesca
name: Cupidi, Chiara
name: Bernardi, Livia
name: Anfossi, Maria
name: Gallo, Maura
name: Conidi, Maria Elena
name: Smirne, Nicoletta
name: Rademakers, Rosa
name: Baker, Matt
name: Dickson, Dennis W.
name: Graff-Radford, Neill R.
name: Petersen, Ronald C.
name: Knopman, David
name: Josephs, Keith A.
name: Boeve, Bradley F.
name: Parisi, Joseph E.
name: Seeley, William W.
name: Miller, Bruce L.
name: Karydas, Anna M.
name: Rosen, Howard
name: Van Swieten, John C.
name: Dopper, Elise G. P.
name: Seelaar, Harro
name: Pijnenburg, Yolande A. L.
name: Scheltens, Philip
name: Logroscino, Giancarlo
name: Capozzo, Rosa
name: Novelli, Valeria
name: Puca, Annibale A.
name: Franceschi, Massimo
name: Postiglione, Alfredo
name: Milan, Graziella
name: Sorrentino, Paolo
name: Kristiansen, Mark
name: Chiang, Huei-Hsin
name: Graff, Caroline
name: Pasquier, Florence
name: Rollin, Adeline
name: Deramecourt, Vincent
name: Lebouvier, Thibaud
name: Kapogiannis, Dimitrios
name: Ferrucci, Luigi
name: Pickering-Brown, Stuart
name: Singleton, Andrew B.
name: Hardy, John
name: Momeni, Parastoo
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Article
/631/114
/631/208
/692/308
/692/617
/692/499
article

description: Funder: QingLan Research Project of Jiangsu for Outstanding Young Teachers
description: Funder: Project funded by Postdoctoral Science Foundation of Xuzhou Medical University
description: Funder: Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) for Xuzhou Medical University
description: Abstract: We employed Mendelian randomization (MR) to evaluate the causal relationship between leukocyte telomere length (LTL) and amyotrophic lateral sclerosis (ALS) with summary statistics from genome-wide association studies (n = ~ 38,000 for LTL and ~ 81,000 for ALS in the European population; n = ~ 23,000 for LTL and ~ 4,100 for ALS in the Asian population). We further evaluated mediation roles of lipids in the pathway from LTL to ALS. The odds ratio per standard deviation decrease of LTL on ALS was 1.10 (95% CI 0.93–1.31, p = 0.274) in the European population and 0.75 (95% CI 0.53–1.07, p = 0.116) in the Asian population. This null association was also detected between LTL and frontotemporal dementia in the European population. However, we found that an indirect effect of LTL on ALS might be mediated by low density lipoprotein (LDL) or total cholesterol (TC) in the European population. These results were robust against extensive sensitivity analyses. Overall, our MR study did not support the direct causal association between LTL and the ALS risk in neither population, but provided suggestive evidence for the mediation role of LDL or TC on the influence of LTL and ALS in the European population.