cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Costs and effectiveness of fingolimod versus alemtuzumab in the treatment of highly active relapsing-remitting multiple sclerosis in the UK: re-treatment, discount, and disutility
Creators: name: Montgomery, Stephen M.
name: Kusel, Jeanette
name: Nicholas, Richard
name: Adlard, Nicholas
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Plant Biology

description: Objective: Patients with relapsing-remitting multiple sclerosis (RRMS) treated with disease modifying therapies (DMTs) who continue to experience disease activity may be considered for escalation therapies such as fingolimod, or may be considered for alemtuzumab. Previous economic modeling used Markov models; applying one alternative technique, discrete event simulation (DES) modeling, allows re-treatment and long-term adverse events (AEs) to be included in the analysis. Methods: A DES was adapted to model relapse-triggered re-treatment with alemtuzumab and the effect of including ongoing quality-adjusted life year (QALY) decrements for AEs that extend beyond previous 1-year Markov cycles. As the price to the NHS of fingolimod in the UK is unknown, due to a confidential patient access scheme (PAS), a variety of possible discounts were tested. The interaction of re-treatment assumptions for alemtuzumab with the possible discounts for fingolimod was tested to determine which DMT resulted in lower lifetime costs. The lifetime QALY results were derived from modeled treatment effect and short- and long-term AEs. Results: Most permutations of fingolimod PAS discount and alemtuzumab re-treatment rate resulted in fingolimod being less costly than alemtuzumab. As the percentage of patients who are re-treated with alemtuzumab due to experiencing a relapse approaches 100% of those who relapse whilst on treatment, the discount required for fingolimod to be less costly drops below 5%. Consideration of treatment effect alone found alemtuzumab generated 0.2 more QALYs/patient; the inclusion of AEs up to a duration of 1 year reduced this advantage to only 0.14 QALYs/patient. Modeling AEs with a lifetime QALY decrement found that both DMTs generated very similar QALYs with the difference only 0.04 QALYs/patient. Conclusions: When the model captured alemtuzumab re-treatment and long-term AE decrements, it was found that fingolimod is cost-effective compared to alemtuzumab, assuming application of only a modest level of confidential PAS discount.
Additional file 1 of Evaluation of two Plasmodium vivax sexual stage antigens as transmission-blocking vaccine candidates
Creators: name: Zhang, Yongzhe
name: Liu, Fei
name: Zhao, Yan
name: Yang, Fan
name: Bai, Jie
name: Jia, Xitong
name: Roobsoong, Wanlapa
name: Sattabongkot, Jetsumon
name: Cui, Liwang
name: Cao, Yaming
name: Luo, Enjie
name: Wang, Meilian
Publisher: name: figshare
Year: 2021
Subjects: subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Figure S1. Alignment analysis of protein sequences of PvPH and PvSOP26 in Plasmodium spp.: P. vivax (Pv), P. knowlesi (Pk), P. falciparum (Pf) and P. berghei (Pb).
PSYCHOLOGY OF CHILDREN WITH HEARING DEFECTS
Creators: name: Mukhitdinova, Diyorakhan
name: Davronova, Sarvinoz
Publisher: name: Zenodo
Year: 2024

description: Nowadays, special attention is paid to the psychology of students and youth in all branches of pedagogical education. Especially in special pedagogy, approaches to the educational process are carried out based on the psychological characteristics and condition of children. Therefore, this article reflects the psychological characteristics of children with hearing impairment.
title: 01_0726
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Additional file 1 of A novel fiber-2-edited live attenuated vaccine candidate against the highly pathogenic serotype 4 fowl adenovirus
Creators: name: Xie, Quan
name: Cao, Shiya
name: Zhang, Wei
name: Wang, Weikang
name: Li, Luyuan
name: Kan, Qiuqi
name: Fu, Hui
name: Geng, Tuoyu
name: Li, Tuofan
name: Wan, Zhimin
name: Gao, Wei
name: Shao, Hongxia
name: Qin, Aijian
name: Ye, Jianqiang
Publisher: name: figshare
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Complete sequence of EGFP_fiber-2.
Stable Charged Gravastar Model in ${f}(\mathfrak{R},\textbf{T}^{2})$ Gravity with Conformal Motion
Creators: name: Sharif, M.
name: Naz, Saba
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: This paper investigates the influence of charge on physical features of gravastars in the framework of energy-momentum squared gravity. A gravastar is an alternate model to a black hole that comprises of three distinct regions, namely the intermediate shell, inner and outer sectors. Different values of the barotropic equation of state parameter provide the mathematical formulation for these regions. We construct the structure of a gravastar admitting conformal motion for a specific model of energy-momentum squared gravity. The field equations are formulated for a spherically symmetric spacetime with charged perfect matter distribution. For the smooth matching of external and internal spacetimes, we use Israel matching criteria. Various physical attributes of gravastars such as the equation of state parameter, proper length, entropy and energy are investigated (in the presence of charge) versus thickness of the shell. The charge in the inner core of gravastars preserves the state of equilibrium by counterbalancing the inward gravitational force. It is concluded that the non-singular solutions of charged gravastar are physically viable in the background of energy-momentum squared gravity.
description: 22 pages, 4 figures, to appear in EPJP
Exérese de odontoma complexo: caso clínico
Creators: name: Lopes, J.
name: Araújo, S.
name: Lopes, J.
name: Silva, A.
name: Almeida, B.
name: Silva, S.
Publisher: name: Cadernos de Saúde
Year: 2008

description: Cadernos de Saúde, v. 1 n. Especial (2008): Medicina Dentária
Risk of stroke/systemic embolism, major bleeding and associated costs in non-valvular atrial fibrillation patients who initiated apixaban, dabigatran or rivaroxaban compared with warfarin in the United States Medicare population
Creators: name: Alpesh Amin
name: Keshishian, Allison
name: Trocio, Jeffrey
name: Oluwaseyi Dina
name: Le, Hannah
name: Rosenblatt, Lisa
name: Xianchen Liu
name: Mardekian, Jack
name: Qisu Zhang
name: Baser, Onur
name: Vo, Lien
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Objective: To compare the risk and cost of stroke/systemic embolism (SE) and major bleeding between each direct oral anticoagulant (DOAC) and warfarin among non-valvular atrial fibrillation (NVAF) patients. Methods: Patients (≥65 years) initiating warfarin or DOACs (apixaban, rivaroxaban, and dabigatran) were selected from the Medicare database from 1 January 2013 to 31 December 2014. Patients initiating each DOAC were matched 1:1 to warfarin patients using propensity score matching to balance demographics and clinical characteristics. Cox proportional hazards models were used to estimate the risks of stroke/SE and major bleeding of each DOAC vs. warfarin. Two-part models were used to compare the stroke/SE- and major-bleeding-related medical costs between matched cohorts. Results: Of the 186,132 eligible patients, 20,803 apixaban–warfarin pairs, 52,476 rivaroxaban–warfarin pairs, and 16,731 dabigatran–warfarin pairs were matched. Apixaban (hazard ratio [HR] = 0.40; 95% confidence interval [CI] 0.31, 0.53) and rivaroxaban (HR = 0.72; 95% CI 0.63, 0.83) were significantly associated with lower risk of stroke/SE compared to warfarin. Apixaban (HR = 0.51; 95% CI 0.44, 0.58) and dabigatran (HR = 0.79; 95% CI 0.69, 0.91) were significantly associated with lower risk of major bleeding; rivaroxaban (HR = 1.17; 95% CI 1.10, 1.26) was significantly associated with higher risk of major bleeding compared to warfarin. Compared to warfarin, apixaban ($63 vs. $131) and rivaroxaban ($93 vs. $139) had significantly lower stroke/SE-related medical costs; apixaban ($292 vs. $529) and dabigatran ($369 vs. $450) had significantly lower major bleeding-related medical costs. Conclusions: Among the DOACs in the study, only apixaban is associated with a significantly lower risk of stroke/SE and major bleeding and lower related medical costs compared to warfarin.
title: 01_2008
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
title: Comité permanente sobre el derecho de marcas, dibujos y modelos industriales e indicaciones geográficas :
title: Informe adoptado por el Comité Permanente.
titleType: Subtitle
Creators: name: (:Unas)
Publisher: name: Unknown
Year: 0

description: El Comité Permanente sobre el Derecho de Marcas, Diseños Industriales e Indicaciones Geográficas (que en lo sucesivo se denominará “el Comité Permanente” o “el SCT”) celebró en Ginebra su vigésima tercera sesión del 30 de junio al 2 de julio de 2010.
The dynamics of volunteer motivations for engaging in the management of invasive plants: insights from a mixed-methods study on Scottish seabird islands
Creators: name: Pagès, Marie
name: Fischer, Anke
name: Wal, René Van Der
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Neuroscience
subject: Ecology
subject: FOS: Biological sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: Volunteers play an important role in the management of natural habitats. Understanding what motivates volunteers to join conservation initiatives and how motivations change over time is essential to enhance the environmental and social benefits of their engagement. Using a repeated qualitative survey and semi-structured interviews, we explore volunteers’ initial and sustained motivations in the management of the invasive tree mallow (Lavatera arborea) on Scottish seabird islands. Caring for nature, the performance of volunteering activities, and social interactions were the main drivers of involvement. Over time, motivations were shaped by the interplay between individual expectations and experiences with the social and ecological context. They changed from identifiable functions to more complex attachments to the place and the group. We discuss the limitations of functional methodologies in making sense of these attachments and of the performative nature of environmental volunteering. We then explore the practical implications of the dynamics of volunteering motivations.
Methods for estimating costs in patients with hyperlipidemia experiencing their first cardiovascular event in the United Kingdom
Creators: name: Danese, Mark D.
name: Gleeson, Michelle
name: Griffiths, Robert I.
name: Catterick, David
name: Kutikova, Lucie
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Aims: Methods for integrating external costs into clinical databases are not well-characterized. The purpose of this research was to describe and implement methods for estimating the cost of hospitalizations, prescriptions, and general practitioner and specialist visits used to manage hyperlipidemia patients experiencing cardiovascular (CV) events in the United Kingdom (UK). Methods: This study was a retrospective cohort study using the Clinical Practice Research Datalink and Hospital Episode Statistics data. Costs were incorporated based on reference costs from the National Health Service, and labor costs from the Personal Social Services Research Unit. The study population included patients seen by general practitioners in the UK from 2006–2012. Patients ≥18 years were selected at the time of their first CV-related hospitalization defined as myocardial infarction, ischemic stroke, heart failure, transient ischemic attack, unstable angina, or revascularization. To be included, patients must have received ≥2 lipid-lowering therapies. Outcome measures included healthcare utilization and direct medical costs for hospitalizations, medications, general practitioner visits, and specialist visits during the 6-month acute period, starting with the CV hospitalization, and during the subsequent 30-month long-term period. Results: There were 24,093 patients with a CV hospitalization included in the cohort. This study identified and costed 69,240 hospitalizations, 673,069 GP visits, 32,942 specialist visits, and 2,572,792 prescriptions, representing 855 unique drug and dose combinations. The mean acute period and mean annualized long-term period costs (2014£) were £4,060 and £1,433 for hospitalizations, £377 and £518 for GP visits, £59 and £103 for specialist visits, and £98 and £209 for medications. Conclusions: Hospital costs represent the largest portion of acute and long-term costs in this population. Detailed costing using utilization data is feasible and representative of UK clinical practice, but is labor intensive. The availability of a standardized coding system in the UK drug costing data would greatly facilitate drug costing.
Acoustic properties of vowels in Upper Necaxa Totonac
Creators: García-Vega, Michelle
Tucker, Benjamin V.
Publisher: name: University of Alberta Library
Year: 2019

Upper Necaxa Totonac is a Totonacan language spoken in the Necaxa River valley in the Sierra Norte of Puebla State, Mexico. While the Totonacan languages historically have three phonemic vowel qualities, the Upper Necaxa system consists of five vowels that contrast length and laryngealization. With acoustic data from six native speakers from the Totonacan communities of Patla and Chicontla, we explore the phonetic properties of vowels with respect to the first and second formant frequencies, quantity (duration), vowel phonation (modal vs. laryngeal), and stress. The data indicate that long, short, modal and laryngeal vowels occupy a similar formant space and that duration is the primary phonetic correlate of phonemic vowel length. A shift in vowel quality and an increase in duration and pitch were shown to be the acoustic characteristics of stress. The study provides a first acoustic analysis of vowels in Upper Necaxa, and contributes to typological descriptions of the properties of vowels connected with quality, quantity, stress, and phonation.
Figure S2: Schematic of an amphiphilic Pluronic F127 molecule binding to a PDMS surface. from Surface functionalization of poly(dimethylsiloxane) substrates facilitates culture of pre-implantation mouse embryos by blocking non-selective adsorption
Creators: name: Hawkins, Jamar
name: Miao, Xiaosu
name: Cui, Wei
name: Sun, Yubing
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Biological Engineering
subject: 90301 Biomaterials
subject: FOS: Medical engineering

description: The hydrophobic polypropylene oxide moiety (red) is seen binding to PDMS, while the polyethylene oxide moiety (black) projects outwards toward the aqueous phase.
Figure S1: Schematic of the PDMS embryo culture well fabrication. from Surface functionalization of poly(dimethylsiloxane) substrates facilitates culture of pre-implantation mouse embryos by blocking non-selective adsorption
Creators: name: Hawkins, Jamar
name: Miao, Xiaosu
name: Cui, Wei
name: Sun, Yubing
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Biological Engineering
subject: 90301 Biomaterials
subject: FOS: Medical engineering

description: The diagram depicts the casting (i), water vapor saturation (ii), Pluronic F127 coating (iii) and KSOM pre-equilibration step for the embryo culture wells (iv).
Figure S3: Blastocyst Rates for 4-Day PDMS Leaching Assay from Surface functionalization of poly(dimethylsiloxane) substrates facilitates culture of pre-implantation mouse embryos by blocking non-selective adsorption
Creators: name: Hawkins, Jamar
name: Miao, Xiaosu
name: Cui, Wei
name: Sun, Yubing
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Biological Engineering
subject: 90301 Biomaterials
subject: FOS: Medical engineering

description: Mean blastocyst rates of embryo cultured on polystyrene dish within KSOM that was fresh (Control), previously placed in a DI-PDMS well for 4 days (4-Day DI-PDMS) or previously placed in a polystyrene dish for 4 days (4-day PS Control). All groups had a P > 0.05 of belonging to the same mean (n.s.). n refers to the number of culture wells used per group.
title: TABARCA
title: TABARCA
title: Atlas archéologique de la Tunisie
Creators: name: Babelon, Ernest Charles François
name: Babelon, Ernest Charles François > Auteur
name: Cagnat, René Louis Victor > Auteur
name: Reinach, Salomon > Auteur
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: subject: Archéologie
subject: Antiquité
subject: Recherche archéologique
subject: Savoirs (Les)
subject: Cartographie
subject: Atlas
subject: Atlas archéologique

description: [Atlas archéologique de la Tunisie ; Edition spéciale des cartes topographiques publiées par la ministère de la Guerre, accompagnée d’un texte explicatif rédigé par E. Babelon, R. Cagnat et S. Reinach, membres de la Commission de l’Afrique du Nord (1ère série, 60 feuilles au 1/50 000 et notices)]
description: Atlas
description: Atlas-Archeo-Tunisie_011
description: 1/50 000
description: La Méditerranée à la carte
description: Paris
description: Source: Institut de recherche sur le Maghreb contemporain (IRMC); Cité numérique de la Méditerranée (MMSH)
description: Source: La Méditerranée à la carte
description: Source: La Méditerranée à la carte > Atlas archéologique de la Tunisie
description: Relation: https://cinumed.mmsh.univ-aix.fr/idurl/1/96181
description: Coverage: Tunisie
description: Coverage: Tabarca
description: Coverage: Antiquité
description: Temporal: Antiquité
description: Provenance: Institut de recherche sur le Maghreb contemporain (IRMC); Cité numérique de la Méditerranée (MMSH)
Deciphering and predict corrosion effect, influencing factors and microbial mechanism of sewer concrete corrosion based on extensive data analysis and machine learning
Creators: name: Wang, Wenhao
name: Xu, Xinxin
name: Cao, Jingguo
name: Zeng, Ming
name: Zhang, Wu
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology

description: This study investigated the effect of environmental parameters on microbial-induced concrete corrosion during three corrosion stages. The corrosion effects and influencing factors in three corrosion stages were deeply analyzed and predicted, and the mechanism of microbial corrosion was summarized. When the H2S concentration was lower than about 15.0 mg/m3, the corrosion was maintained in stage II, which greatly delays the intensification of corrosion. In stage III, the H2S concentration has the significantly accelerate the corrosion rate. Additionally, incorporating min, max and mean values of input parameters greatly improved the accuracy of machine learning predictions of corrosion rates (R2 >0.99). Acidithiobacillus was found to be dominant in the microbial community at H2S concentrations of 12.0–37.5 mg/m3, and increased temperature promoted the reproduction of Acidithiobacillus.
title: ColocZStats: a 3D Slicer extension for assessing colocalization in confocal microscopy
Creators: name: Chen, Xiang
Publisher: name: Memorial University of Newfoundland
publisherIdentifier: https://ror.org/04haebc03
publisherIdentifierScheme: ROR
Year: 2024

description: Confocal microscopy has evolved as a widely adopted imaging technique in molecular biology and is frequently utilized to achieve accurate subcellular localization of proteins. Applying colocalization analysis on image z-stacks obtained from confocal fluorescence microscopes is a dependable method to reveal the association between different molecules. In addition, despite the established advantages and growing adoption of virtual reality (VR) technology in various microscopy research domains, there has been a scarcity of systems supporting colocalization analysis within VR space. In this context, several broadly employed biological image visualization platforms were meticulously explored in this study to comprehend the current landscape. It has been observed that while these applications can generate three-dimensional (3D) reconstructions for the z-stacks and transfer them into an immersive VR scene, there is still a common necessity for them to optimize the capability for executing quantitative colocalization analysis on such images. To constructively improve the above circumstances, an extension called ColocZStats has been developed for 3D Slicer. With a user-friendly interface, ColocZStats allows investigators to conduct intensity thresholding and region-of-interest (ROI) selection on imported 3D image stacks. It can deliver several essential colocalization metrics for structures of interest in the form of diagrams and spreadsheets. While currently serving as a desktop tool, ColocZStats has been continuously enhanced and will be systematically extended into VR in the next phase.
title: Dominique Mathez, P. Bagnarelli, P. de Truchis, I. Gorin, C. Katlama, G. Pialoux, C. Ruggeri, A.G. Saimot, R. Tubiana, J.-P. Chauvin, M. Clementi, J. Leibowitch, "A triple combination of Ritonavir AZT DDC as a first line treatment of patients with AIDS : update"
Creators: name: Bagnarelli, Patrizia
name: Clementi, Massimo
name: de Truchis, Pierre
name: Gorin, Isabelle
name: Katlama, Christine
name: Mathez, Dominique
name: Ruggeri, Catherine
name: Saimot, Adrien Gérard
name: Pialoux, Gilles (1956-....)
name: Tubiana, Roland (19..-....)
name: Chauvin, Jean-Pierre (1948-....)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Résumé.
description: Source: http://www.calames.abes.fr/pub/ms/Calames-201931110317981103
Carnet nº 1 : description des travaux accomplis sur le tour de France (p. 34)
Creators: name: Péraire, Lucien
name: CNRS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023

description: created: 10-8-1928
Changes in the chemical compositions of leaf litter in the canopy of a Japanese cedar plantation
Creators: name: Matsushita, Aya
name: Yoshida, Tomohiro
name: Hijii, Naoki
name: Takenaka, Chisato
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Molecular Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: Plant Biology

description: Canopy leaf litter is typically unevenly distributed due to interception by branches and epiphytes and/or due to attachment to branches and tree trunks. Japanese cedar (Cryptomeria japonica) trees hold a large amount of canopy litter that stays attached to foliage and branches for several years before litterfall. Litter retention in the canopy is predicted to affect the chemical composition of litterfall and throughfall. We analyzed the chemical compositions of water-soluble materials washed from the leaves and those of the leaf residues with different leaf litter ages to clarify the effect of leaf-litter retention in the canopy of Japanese cedar trees. Chemical components of the leaf litter after the washing procedure show temporal changes in total carbon, total nitrogen, and carbon/nitrogen ratio just after senescence and prior to litterfall. Higher inorganic ion concentrations in soluble materials from old dead leaves (ODL) dead for more than 2 years suggest the importance of ODL in leaching and catching chemical components in the canopy. Our results show that Japanese cedar canopies retain the various qualities of leaf litter, which are produced by senescence, leaching, and catching dry deposition, and that a large amount of dissolved components leach from dead leaves that are still attached to the canopy.
Network meta-analysis of liraglutide versus DPP-4 inhibitors for the treatment of Type 2 diabetes in Japanese patients.
Creators: name: Ayers, Dieter
name: Kanters, Steve
name: Goldgrub, Rachel
name: Hughes, Monica
name: Kato, Ryo
name: Kragh, Nana
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Aims: To determine the comparative efficacy and safety of liraglutide and dipeptidyl peptidiase-4 (DPP-4) inhibitors as antidiabetics for Japanese patients with uncontrolled type 2 diabetes (T2DM). Methods and Materials: We searched for randomized-controlled trials (RCTs) evaluating outcomes among Japanese adults with uncontrolled T2DM and including liraglutide or DPP-4 inhibitors up to August 2016. We extracted data on trial and patient characteristics, and the following outcomes: HbA1c, weight, patients meeting HbA1c <7%, patients experiencing hypoglycemic events, microalbuminuria, estimated glomerular filtration rate (eGFR) and creatinine. We synthesized data using network meta-analyses (NMA) using a Bayesian framework. Continuous outcomes were modelled using Normal likelihoods and an identity link, while dichotomous outcomes were modelled using a binomial likelihood and a logit link. Results: The systematic literature review yielded 39 publications pertaining to 38 trials. A total of 27 trials (5032 patients) reported change in HbA1c at 12 weeks and at 24 weeks 9 trials (2091 patients). All treatments showed statistically significant reductions in HbA1c relative to placebo at 12 and 24 weeks. Liraglutide 0.9 mg was statistically superior to all DPP-4 interventions (vildagliptin, sitagliptin, linagliptin, alogliptin, tenelglipin, trelagliptin and omaragliptin) at 12 weeks and 24 weeks among those reporting. Treatments were not statistically differentiable with respect to weight change and risk of hypoglycemia. Finally, no comparisons of eGFR and microalbuminuria were conducted, as these data were reported in too few trials to conduct analyses. Limitations: Some important outcomes were limited by poor reporting (eGFR and microalbuminuria) or low event rates (hypoglycemia). The follow-up time was relatively short. Clinically, the 24-week time point is more important as it demonstrates more sustained results. Conclusions: Our research suggests that liraglutide 0.9mg offers a more efficacious treatment option for T2DM than the DPP-4 inhibitors among adult Japanese patients and that it is a viable option for this population.
Figure S3: Blastocyst Rates for 4-Day PDMS Leaching Assay from Surface functionalization of poly(dimethylsiloxane) substrates facilitates culture of preimplantation mouse embryos by blocking nonselective adsorption
Creators: name: Hawkins, Jamar
name: Miao, Xiaosu
name: Cui, Wei
name: Sun, Yubing
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Biological Engineering
subject: 90301 Biomaterials
subject: FOS: Medical engineering

description: Mean blastocyst rates of embryo cultured on polystyrene dish within KSOM that was fresh (Control), previously placed in a DI-PDMS well for 4 days (4-Day DI-PDMS) or previously placed in a polystyrene dish for 4 days (4-day PS Control). All groups had a P > 0.05 of belonging to the same mean (n.s.). n refers to the number of culture wells used per group.
Figure S1: Schematic of the PDMS embryo culture well fabrication. from Surface functionalization of poly(dimethylsiloxane) substrates facilitates culture of preimplantation mouse embryos by blocking nonselective adsorption
Creators: name: Hawkins, Jamar
name: Miao, Xiaosu
name: Cui, Wei
name: Sun, Yubing
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Biological Engineering
subject: 90301 Biomaterials
subject: FOS: Medical engineering

description: The diagram depicts the casting (i), water vapor saturation (ii), Pluronic F127 coating (iii) and KSOM pre-equilibration step for the embryo culture wells (iv).
Costs and effectiveness of fingolimod versus alemtuzumab in the treatment of highly active relapsing-remitting multiple sclerosis in the UK: retreatment, discount and disutility
Creators: name: Montgomery, Stephen M.
name: Kusel, Jeanette
name: Nicholas, Richard
name: Adlard, Nicholas
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Objective: Patients with relapsing-remitting multiple sclerosis (RRMS) treated with disease modifying therapies (DMTs) who continue to experience disease activity may be considered for escalation therapies such as fingolimod or may be considered for alemtuzumab. Previous economic modelling used Markov models; applying one alternative technique, discrete event simulation (DES) modelling, allows retreatment and long-term adverse events (AEs) to be included in the analysis. Methods: A DES was adapted to model relapse-triggered retreatment with alemtuzumab and the effect of including ongoing quality-adjusted life year (QALY) decrements for AEs that extend beyond previous one year Markov cycles. As the price to the NHS of fingolimod in the UK is unknown due to a confidential patient access scheme (PAS), a variety of possible discounts were tested. The interaction of retreatment assumptions for alemtuzumab with the possible discounts for fingolimod was tested to determine which DMT resulted in lower life-time costs. The life-time QALY results were derived from modelled treatment effect and short- and long-term AEs. Results: Most permutations of fingolimod PAS discount and alemtuzumab retreatment rate resulted in fingolimod being less costly than alemtuzumab. As the percentage of patients who are retreated with alemtuzumab due to experiencing a relapse approaches 100% of those who relapse whilst on treatment, the discount required for fingolimod to be less costly drops below 5%. Consideration of treatment effect alone found alemtuzumab generated 0.2 more QALYs/patient; the inclusion of AEs up to a duration of one year reduced this advantage to only 0.14 QALYs/patient. Modelling AEs with a lifetime QALY decrement found that both DMTs generated very similar QALYs with the difference only 0.04 QALYs/patient. Conclusions: When the model captures alemtuzumab retreatment and long term AE decrements, it was found that fingolimod is cost effective compared to alemtuzumab assuming application of only a modest level of confidential PAS discount.
Sepsis favors high-on-clopidogrel platelet reactivity
Creators: name: Akinosoglou, Karolina
name: Perperis, Angelos
name: Theodoraki, Spyridoula
name: Alexopoulos, Dimitrios
name: Gogos, Charalambos
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: 110309 Infectious Diseases

description: High-on-treatment platelet reactivity (HPR) is associated with ischemic events in patients on antiplatelet therapy with a history of cardiovascular disease. On the other hand, recent data have associated sepsis with adverse cardiovascular events in patients admitted with bacteremia or respiratory infection. We aimed to assess P2Y12-mediated platelet reactivity (PR) during sepsis and recovery in patients under clopidogrel. This was a prospective observational study. Incoming patients presenting with signs/symptoms of sepsis already on a maintenance dose of clopidogrel of 75 mg qd for cardiovascular events were included in this study. Patients were assessed for their PR on presentation and following septic syndrome, using the VerifyNow point-of-care P2Y12 assay. Patients were excluded in the presence of evidence of noncompliance to antiplatelet regimen or in need of discontinuation during this study. Twenty-two septic patients on clopidogrel were included in this study (Supplemental Figure S1). Clopidogrel was administered for previous stroke, coronary, and peripheral artery disease in 27.3, 40.9, and 31.8% of patients, respectively. The main site of infection was respiratory tract followed by urinary tract, while the same amounts of gram-negative and -positive pathogens were isolated. HPR was noted in 77% and 29% of patients during sepsis and recovery, respectively, presenting a significant decrease in P2Y12 reaction units values during follow-up [240.7 ± 58.3 versus 179.5 ± 58.4, 95% CI (–102.7, –39.76), p = 0.0002]. Five patients died of infection, while no adverse cardiovascular events were noted in our study. Our study shows that sepsis may favor HPR, which is reversed when recovery occurs. This finding may underlie the adverse cardiovascular events in patients admitted with sepsis, possibly requiring alteration of antiplatelet regimen during the inflammation period.
Risk of stroke/systemic embolism, major bleeding and associated costs in non-valvular atrial fibrillation patients who initiated apixaban, dabigatran, or rivaroxaban compared with warfarin in the United States Medicare population
Creators: name: Alpesh Amin
name: Keshishian, Allison
name: Trocio, Jeffrey
name: Oluwaseyi Dina
name: Le, Hannah
name: Rosenblatt, Lisa
name: Xianchen Liu
name: Mardekian, Jack
name: Qisu Zhang
name: Baser, Onur
name: Vo, Lien
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Objective: To compare the risk and cost of stroke/systemic embolism (SE) and major bleeding between each direct oral anticoagulant (DOAC) and warfarin among non-valvular atrial fibrillation (NVAF) patients. Methods: Patients (≥65 years) initiating warfarin or DOACs (apixaban, rivaroxaban, and dabigatran) were selected from the Medicare database from 01/01/2013-12/31/2014. Patients initiating each DOAC were matched 1:1 to warfarin patients using propensity score matching to balance demographics and clinical characteristics. Cox proportional hazards models were used to estimate the risks of stroke/SE and major bleeding of each DOAC vs warfarin. Two-part models were used to compare the stroke/SE- and major bleeding-related medical costs between matched cohorts. Results: Of the 186,132 eligible patients, 20,803 apixaban-warfarin pairs, 52,476 rivaroxaban-warfarin pairs, and 16,731 dabigatran-warfarin pairs were matched. Apixaban (Hazard Ratio [HR] = 0.40; 95% Confidence Interval [CI] 0.31-0.53) and rivaroxaban (HR = 0.72; 95% CI 0.63-0.83) were significantly associated with lower risk of stroke/SE compared to warfarin. Apixaban (HR = 0.51; 95% CI 0.44-0.58) and dabigatran (HR = 0.79; 95% CI 0.69-0.91) were significantly associated with lower risk of major bleeding; rivaroxaban (HR = 1.17; 95% CI 1.10-1.26) was significantly associated with higher risk of major bleeding compared to warfarin. Compared to warfarin, apixaban ($63 vs $131) and rivaroxaban ($93 vs $139) had significantly lower stroke/SE-related medical costs; apixaban ($292 vs $529) and dabigatran ($369 vs $450) had significantly lower major bleeding-related medical costs. Conclusions: Among the DOACs in the study, only apixaban is associated with a significantly lower risk of stroke/SE and major bleeding and lower related medical costs compared to warfarin.
Antibiotics: An overview on the environmental occurrence, toxicity, degradation, and removal methods
Creators: name: Yang, Qiulian
name: Gao, Yuan
name: Ke, Jian
name: Show, Pau Loke
name: Ge, Yuhui
name: Liu, Yanhua
name: Guo, Ruixin
name: Chen, Jianqiu
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Antibiotics, as antimicrobial drugs, have been widely applied as human and veterinary medicines. Recently, many antibiotics have been detected in the environments due to their mass production, widespread use, but a lack of adequate treatment processes. The environmental occurrence of antibiotics has received worldwide attention due to their potential harm to the ecosystem and human health. Research status of antibiotics in the environment field is presented by bibliometrics. Herein, we provided a comprehensive overview on the following important issues: (1) occurrence of antibiotics in different environmental compartments, such as wastewater, surface water, and soil; (2) toxicity of antibiotics toward non-target organisms, including aquatic and terrestrial organisms; (3) current treatment technologies for the degradation and removal of antibiotics, including adsorption, hydrolysis, photodegradation and oxidation, and biodegradation. It was found that macrolides, fluoroquinolones, tetracyclines, and sulfonamides were most frequently detected in the environment. Compared to surface and groundwaters, wastewater contained a high concentration of antibiotic residues. Both antibiotics and their metabolites exhibited toxicity to non-target organisms, especially aquatic organisms (e.g., algae and fish). Fluoroquinolones, tetracyclines, and sulfonamides can be removed through abiotic process, such as adsorption, photodegradation, and oxidation. Fluoroquinolones and sulfonamides can directly undergo biodegradation. Further studies on the chronic effects of antibiotics at environmentally relevant concentrations on the ecosystem were urgently needed to fully understand the hazards of antibiotics and help the government to establish the permissible limits. Biodegradation is a promising technology; it has numerous advantages such as cost-effectiveness and environmental friendliness.
Additional file 1 of CDX2 and Reg IV expression and correlation in gastric cancer
Creators: name: Chai, Dandan
name: Du, Huifen
name: Li, Kesheng
name: Zhang, Xueliang
name: Li, Xiaoqin
name: Zhao, Xiaoning
name: Lian, Xiaowen
name: Xu, Yang
Publisher: name: figshare
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Figure S1. Original blots of CDX2 for Figs. 2–4. (a) Fig. 2b and Fig. 3b. (b) Fig. 4a. (c) Fig. 4c. (d) Fig. 3d. (e) Fig. 2d, Fig. 4b, and Fig. 4d. Any lanes not included in the final figures or not related to the results in this manuscript were not marked on the original blot images. Figure S2. Original blots of Reg IV for Figs. 2–4. (a) Fig. 4a and Fig. 4c. (b) Fig. 3b. (c) Fig. 2b. (d–g) Fig. 3d and Fig. 4d. Exposure times were 2 s, 14.1 s, 38.3 s, and 607.0 s, respectively. (h) Fig. 4b. (i) Fig. 2d. Any lanes not included in the final figures or not related to the results in this manuscript were not marked on the original blot images. Figure S3. Original blots of β-actin for Figs. 2–4. (a) Fig. 2b and Fig. 3b. (b) Fig. 4a and Fig. 4c. (c) Fig. 3d and Fig. 4d. (d) Fig. 2d. Any lanes not included in the final figures or not related to the results in this manuscript were not marked on the original blot images.
Supplementary figures from Rapid evolution mitigates the ecological consequences of an invasive species (Bythotrephes longimanus) in lakes in Wisconsin
Creators: name: Gillis, Michael K.
name: Walsh, Matthew R.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology

description: Invasive species have extensive negative consequences for biodiversity and ecosystem health. Novel species also drive contemporary evolution in many native populations, which could mitigate or amplify their impacts on ecosystems. The predatory zooplankton, Bythotrephes longimanus, invaded lakes in Wisconsin, USA, in 2009. This invasion caused precipitous declines in zooplankton prey (Daphnia pulicaria), with cascading impacts on ecosystem services (water clarity). Here, we tested the link between Bythotrephes invasion, evolution in Daphnia and post-invasion ecological dynamics using 15 years of long-term data in conjunction with comparative experiments. Invasion by Bythotrephes is associated with rapid increases in the body size of Daphnia. Laboratory experiments revealed that such shifts have a genetic component; third-generation laboratory-reared Daphnia from ‘invaded’ lakes are significantly larger and exhibit greater reproductive effort than individuals from ‘uninvaded’ lakes. This trajectory of evolution should accelerate Daphnia population growth and enhance population persistence. We tested this prediction by comparing analyses of long-term data with laboratory-based simulations, and show that rapid evolution in Daphnia is associated with increased population growth in invaded lakes.
Figure S2: Schematic of an amphiphilic Pluronic F127 molecule binding to a PDMS surface. from Surface functionalization of poly(dimethylsiloxane) substrates facilitates culture of preimplantation mouse embryos by blocking nonselective adsorption
Creators: name: Hawkins, Jamar
name: Miao, Xiaosu
name: Cui, Wei
name: Sun, Yubing
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Biological Engineering
subject: 90301 Biomaterials
subject: FOS: Medical engineering

description: The hydrophobic polypropylene oxide moiety (red) is seen binding to PDMS, while the polyethylene oxide moiety (black) projects outwards toward the aqueous phase.