Emergence of methicillin resistance predates the clinical use of antibiotics.
Creators: name: Larsen, Jesper
name: Raisen, Claire L
name: Ba, Xiaoliang
name: Sadgrove, Nicholas J
name: Padilla-González, Guillermo F
name: Simmonds, Monique SJ
name: Loncaric, Igor
name: Kerschner, Heidrun
name: Apfalter, Petra
name: Hartl, Rainer
name: Deplano, Ariane
name: Vandendriessche, Stien
name: Černá Bolfíková, Barbora
name: Hulva, Pavel
name: Arendrup, Maiken C
name: Hare, Rasmus K
name: Barnadas, Céline
name: Stegger, Marc
name: Sieber, Raphael N
name: Skov, Robert L
name: Petersen, Andreas
name: Angen, Øystein
name: Rasmussen, Sophie L
name: Espinosa-Gongora, Carmen
name: Aarestrup, Frank M
name: Lindholm, Laura J
name: Nykäsenoja, Suvi M
name: Laurent, Frederic
name: Becker, Karsten
name: Walther, Birgit
name: Kehrenberg, Corinna
name: Cuny, Christiane
name: Layer, Franziska
name: Werner, Guido
name: Witte, Wolfgang
name: Stamm, Ivonne
name: Moroni, Paolo
name: Jørgensen, Hannah J
name: De Lencastre, Hermínia
name: Cercenado, Emilia
name: García-Garrote, Fernando
name: Börjesson, Stefan
name: Hæggman, Sara
name: Perreten, Vincent
name: Teale, Christopher J
name: Waller, Andrew S
name: Pichon, Bruno
name: Curran, Martin D
name: Ellington, Matthew J
name: Welch, John
name: Peacock, Sharon
name: Seilly, David J
name: Morgan, Fiona
name: Parkhill, Julian
name: Hadjirin, Nazreen F
name: Lindsay, Jodi A
name: Holden, Matthew TG
name: Edwards, Giles F
name: Foster, Geoffrey
name: Paterson, Gavin K
name: Didelot, Xavier
name: Holmes, Mark
name: Harrison, Ewan
name: Larsen, Anders R
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Article
/631/92/349/977
/631/158/1745
/631/326/22/1434
/631/326/41/2529
/631/326/41/1470
/45/22
/45/23
/101/58
article

description: The discovery of antibiotics more than 80 years ago has led to considerable improvements in human and animal health. Although antibiotic resistance in environmental bacteria is ancient, resistance in human pathogens is thought to be a modern phenomenon that is driven by the clinical use of antibiotics1. Here we show that particular lineages of methicillin-resistant Staphylococcus aureus-a notorious human pathogen-appeared in European hedgehogs in the pre-antibiotic era. Subsequently, these lineages spread within the local hedgehog populations and between hedgehogs and secondary hosts, including livestock and humans. We also demonstrate that the hedgehog dermatophyte Trichophyton erinacei produces two β-lactam antibiotics that provide a natural selective environment in which methicillin-resistant S. aureus isolates have an advantage over susceptible isolates. Together, these results suggest that methicillin resistance emerged in the pre-antibiotic era as a co-evolutionary adaptation of S. aureus to the colonization of dermatophyte-infected hedgehogs. The evolution of clinically relevant antibiotic-resistance genes in wild animals and the connectivity of natural, agricultural and human ecosystems demonstrate that the use of a One Health approach is critical for our understanding and management of antibiotic resistance, which is one of the biggest threats to global health, food security and development.