cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Multivalent Polyanionic 2D Nanosheets Functionalized Nanofibrous Stem Cell-based Neural Scaffolds
Creators: name: Xia, Yi
name: Yang, Hua
name: Li, Shuang
name: Zhou, Suqiong
name: Wang, Liyun
name: Tang, Yuanjiao
name: Cheng, Chong
name: Haag, Rainer
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: bio‐adhesive graphene nanostructures
subject: adhesive graphene nanostructures
subject: multivalent polyanions
subject: nanofibrous scaffolds
subject: neural differentiation
subject: stem cell regeneration
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Because developed neural cells are no longer regenerative and proliferative, achieving neural regenerations by using induced pluripotent stem cells (IPS cells) for nerve diseases have recently attracted much attention. Since the IPS cells' growth and differentiation can be manipulated by different physical and chemicals cues, scaffolds combining the beneficial nanostructures and extracellular matrix may become an ideal interface to promote IPS cells' neural differentiation. In this work, a biocompatible and multivalent polyanion, hyperbranched polyglycerol sulfate, is used to modify the graphene oxide to obtain bio-adhesive 2D nanosheets. After coating electrospinning nanofibers, the 2D nanosheets-functionalized nanofibrous scaffolds are applied to mediate the proliferation, lineage specification, and neural differentiation of IPS cells. The results suggest that the modified scaffolds can improve the adhesion and proliferation of IPS cells combined with high efficiency in maintaining their stemness. During the neural differentiation process, the scaffolds can promote neural differentiation and their maturity, meanwhile decreasing the lineage specification toward astrocyte. Overall, this study not only provides new multivalent/bio-adhesive nanofibrous scaffolds that integrate the chemical and physical cues to facilitate the targeted neural differentiation of IPS cells but also presents a novel pathway for the fabrication of carbon nanomaterials-based biocomposites in regenerative therapies.
Martin Baumeister, Bruno Bonomo, Dieter Schott (ed.), Cities Contested. Urban Politics, Heritage, and Social Movements in Italy and West Germany in the 1970s, Frankfurt a. M. (Campus Verlag) 2017
Creators: name: Hudemann, Rainer
Publisher: name: Francia-Recensio
Year: 2019

description: Martin Baumeister, Bruno Bonomo, Dieter Schott (ed.), Cities Contested. Urban Politics, Heritage, and Social Movements in Italy and West Germany in the 1970s, Frankfurt a. M. (Campus Verlag) 2017, 382 p., 35 fig., ISBN 978-3-593-50697-5, EUR 49,95
description: Francia-Recensio, 2019/2
Tristan Coignard, Une histoire d’avenir. L’Allemagne et la France face au défi cosmopolitique (1789–1925), Heidelberg (Universitätsverlag Winter) 2017
Creators: name: Merlio, Gilbert
Publisher: name: Francia-Recensio
Year: 2019

description: Tristan Coignard, Une histoire d’avenir. L’Allemagne et la France face au défi cosmopolitique (1789–1925), Heidelberg (Universitätsverlag Winter) 2017, 513 p. (Beihefte zum Euphorion. Zeitschrift für Literaturgeschichte. Heft 96), ISBN 978-3-8253-6667-4, EUR 88,00
description: Francia-Recensio, 2019/2
Simulation and modeling of the electronic structure of GaAs damage clusters
Creators: name: Moussa, Jonathan E.
name: Foiles, Stephen M.
name: Schultz, Peter A.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: In an effort to build a stronger microscopic foundation for radiation damage models in gallium arsenide (GaAs), the electronic properties of radiation-induced damage clusters are studied with atomistic simulations. Molecular dynamics simulations are used to access the time and length scales required for direct simulation of a collision cascade, and density functional theory simulations are used to calculate the electronic properties of isolated damaged clusters that are extracted from these cascades. To study the physical properties of clusters, we analyze the statistics of a randomly-generated ensemble of damage clusters because no single cluster adequately represents this class of defects. The electronic properties of damage clusters are accurately described by a classical model of the electrical charging of a semiconducting sphere embedded in an uniform dielectric. The effective band gap of the cluster depends on the degree of internal structural damage, and the gap closes to form a metal in the high-damage limit. We estimate the Fermi level of this metallic state, which corresponds to high-energy amorphous GaAs, to be 0.46 +/- 0.07 eV above the valence band edge of crystalline GaAs.
Lothar Machtan, Kaisersturz. Vom Scheitern im Herzen der Macht 1918, Darmstadt (Wissenschaftliche Buchgesellschaft) 2018
Creators: name: Lahme, Rainer
Publisher: name: Francia-Recensio
Year: 2019

description: Lothar Machtan, Kaisersturz. Vom Scheitern im Herzen der Macht 1918, Darmstadt (Wissenschaftliche Buchgesellschaft) 2018, 350 S., 49 s/w Abb., ISBN 978-3-8062-3760-3, EUR 24,00
description: Francia-Recensio, 2019/2
Emerging field of few-layered intercalated 2D materials
Creators: name: Cao, Qing
name: Grote, Fabian
name: Hußmann, Marleen
name: Eigler, Siegfried
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: 2D materials
subject: intercalation
subject: intercalating few-layers
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

description: The chemistry and physics of intercalated layered 2D materials (2DMs) are the focus of this review article. Special attention is given to intercalated bilayer and few-layer systems. Thereby, intercalated few-layers of graphene and transition metal dichalcogenides play the major role; however, also other intercalated 2DMs develop fascinating properties with thinning down. Here, we briefly introduce the historical background of intercalation and explain concepts, which become relevent with intercalating few-layers. Then, we describe various synthetic methods to yield intercalated 2DMs and focus next on current research directions, which are superconductivity, band gap tuning, magnetism, optical properties, energy storage and chemical reactions. We focus on major breakthroughs in all introduced sections and give an outlook to this emerging field of research.
Analytic study of properties of holographic p-wave superconductors
Creators: name: Gangopadhyay, Sunandan
name: Roychowdhury, Dibakar
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this paper, we analytically investigate the properties of p-wave holographic superconductors in $AdS_{4}$-Schwarzschild background by two approaches, one based on the Sturm-Liouville eigenvalue problem and the other based on the matching of the solutions to the field equations near the horizon and near the asymptotic $AdS$ region. The relation between the critical temperature and the charge density has been obtained and the dependence of the expectation value of the condensation operator on the temperature has been found. Our results are in very good agreement with the existing numerical results. The critical exponent of the condensation also comes out to be 1/2 which is the universal value in the mean field theory.
description: Latex, To appear in JHEP
Horst Möller, Aleksandr O. Čubar’jan (Hg.), Der Erste Weltkrieg. Deutschland und Russland im europäischen Kontext, Berlin, Boston, MA (De Gruyter) 2017
Creators: name: Geist, Manuel
Publisher: name: Francia-Recensio
Year: 2019

description: Horst Möller, Aleksandr O. Čubar’jan (Hg.), Der Erste Weltkrieg. Deutschland und Russland im europäischen Kontext, Berlin, Boston, MA (De Gruyter) 2017, VIII–176; VIII–182 S., 4 Abb. (Mitteilungen der Gemeinsamen Kommission für die Erforschung der jüngeren Geschichte der deutsch-russischen Beziehungen, 7), ISBN 978-3-11-048223-2, EUR 59,95
description: Francia-Recensio, 2019/2
Particulate matter emissions during field application of poultry manure - The influence of moisture content and treatment
Creators: name: Kabelitz, Tina
name: Biniasch, Oliver
name: Ammon, Christian
name: Nübel, Ulrich
name: Thiel, Nadine
name: Janke, David
name: Swaminathan, Senthilathiban
name: Rösler, Uwe
name: Siller, Paul
name: Amon, Thomas
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: Dry matter content
subject: Fine dust
subject: Bacteria
subject: Organic fertilizer
subject: Broiler litter
subject: Livestock
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

description: Along with industry and transportation, agriculture is one of the main sources of primary particulate matter (PM) emissions worldwide. Bioaerosol formation and PM release during livestock manure field application and the associated threats to environmental and human health are rarely investigated. In the temperate climate zone, field fertilization with manure seasonally contributes to local PM air pollution regularly twice per year (spring and autumn). Measurements in a wind tunnel, in the field and computational fluid dynamics (CFD) simulations were performed to analyze PM aerosolization during poultry manure application and the influence of manure moisture content and treatment. A positive correlation between manure dry matter content (DM) and PM release was observed. Therefore, treatments strongly increasing the DM of poultry manure should be avoided. However, high manure DM led to reduced microbial abundance and, therefore, to a lower risk of environmental pathogen dispersion. Considering the findings of PM and microbial measurements, the optimal poultry manure DM range for field fertilization was identified as 50–70%. Maximum PM10 concentrations of approx. 10 mg per m3 of air were measured during the spreading of dried manure (DM 80%), a concentration that is classified as strongly harmful. The modeling of PM aerosolization processes indicated a low health risk beyond a distance of 400 m from the manure application source. The detailed knowledge about PM aerosolization during manure field application was improved with this study, enabling manure management optimization for lower PM aerosolization and pathogenic release into the environment.
Hyperpolarization of cis-15N2-Azobenzene by Parahydrogen at Ultralow Magnetic Fields
Creators: name: Sheberstov, Kirill F.
name: Kozinenko, Vitaly P.
name: Kiryutin, Alexey S.
name: Vieth, Hans-Martin
name: Zimmermann, Herbert
name: Ivanov, Konstantin L.
name: Yurkovskaya, Alexandra V.
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: Parahydrogen
subject: NMR
subject: SABRE
subject: azobenzene
subject: ZULF
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::541 Physikalische Chemie

description: The development of nuclear spins hyperpolarization, and the search for molecules that can be efficiently hyperpolarized is an active area in nuclear magnetic resonance. In this work we present a detailed study of SABRE SHEATH (signal amplification by reversible exchange in shield enabled alignment transfer to heteronuclei) experiments on 15N2-azobenzene. In SABRE SHEATH experiments the nuclear spins of the target are hyperpolarized through transfer of spin polarization from parahydrogen at ultralow fields during a reversible chemical process. Azobenzene exists in two isomers, trans and cis. We show that all nuclear spins in cis-azobenzene can be efficiently hyperpolarized by SABRE at suitable magnetic fields. Enhancement factors (relative to 9.4 T) reach up to 3000 for 15N spins and up to 30 for the 1H spins. We compare two approaches to observe either hyperpolarized magnetization of 15N/1H spins, or hyperpolarized singlet order of the 15N spin pair. The results presented here will be useful for further experiments in which hyperpolarized cis-15N2-azobenzene is switched by light to trans-15N2-azobenzene for storing the produced hyperpolarization in the long-lived spin state of the 15N pair of trans-15N2-azobenzene.
Martin Mulsow, Kasper Risbjerg Eskildsen, Helmut Zedelmaier (Hg.), Christoph August Heumann (1681–1764). Gelehrte Praxis zwischen christlichem Humanismus und Aufklärung, Stuttgart (Franz Steiner Verlag) 2017
Creators: name: Weber, Wolfgang E. J.
Publisher: name: Francia-Recensio
Year: 2019

description: Martin Mulsow, Kasper Risbjerg Eskildsen, Helmut Zedelmaier (Hg.), Christoph August Heumann (1681–1764). Gelehrte Praxis zwischen christlichem Humanismus und Aufklärung, Stuttgart (Franz Steiner Verlag) 2017, XVI–265 S., 6 s/w Abb. (Gothaer Forschungen zur Frühen Neuzeit, 12), ISBN 978-3-515-09647-8, EUR 54,00.
description: Francia-Recensio, 2019/2
Interleukin-33 signaling exacerbates experimental infectious colitis by enhancing gut permeability and inhibiting protective Th17 immunity
Creators: name: Palmieri, Vittoria
name: Ebel, Jana-Fabienne
name: Phuong, Nhi Ngo Thi
name: Klopfleisch, Robert
name: Vu, Vivian Pham
name: Adamczyk, Alexandra
name: Zöller, Julia
name: Riedel, Christian
name: Buer, Jan
name: Krebs, Philippe
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: microbial pathogens
subject: intestinal infections
subject: cytokines
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: A wide range of microbial pathogens is capable of entering the gastrointestinal tract, causing infectious diarrhea and colitis. A finely tuned balance between different cytokines is necessary to eradicate the microbial threat and to avoid infection complications. The current study identified IL-33 as a critical regulator of the immune response to the enteric pathogen Citrobacter rodentium. We observed that deficiency of the IL-33 signaling pathway attenuates bacterial-induced colitis. Conversely, boosting this pathway strongly aggravates the inflammatory response and makes the mice prone to systemic infection. Mechanistically, IL-33 mediates its detrimental effect by enhancing gut permeability and by limiting the induction of protective T helper 17 cells at the site of infection, thus impairing host defense mechanisms against the enteric pathogen. Importantly, IL-33-treated infected mice supplemented with IL-17A are able to resist the otherwise strong systemic spreading of the pathogen. These findings reveal a novel IL-33/IL-17A crosstalk that controls the pathogenesis of Citrobacter rodentium-driven infectious colitis. Manipulating the dynamics of cytokines may offer new therapeutic strategies to treat specific intestinal infections.
Complete stationary surfaces in R^4_1 with total Gaussian curvature 6π
Creators: name: Ma, Xiang
Publisher: name: arXiv
Year: 2012
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 53A10, 53C42, 53C45

description: In a previous paper we classified complete stationary surfaces (i.e. spacelike surfaces with zero mean curvature) in 4-dimensional Lorentz space $\mathbb{R}^4_1$ which are algebraic and with total Gaussian curvature $-\int K\mathrm{d}M=4π$. Here we go on with the study of such surfaces with $-\int K\mathrm{d}M=6π$. It is shown in this paper that the topological type of such a surface must be a Möbius strip. On the other hand, new examples with a single good singular end are shown to exist.
description: 16 pages. The original proof of Lemma 4.1 is not correct because the Laurent series I used converges only locally; instead my new proof uses partial fraction decomposition which is always valid on the whole extended complex plane. Several math typos are corrected. A reference is removed. Accepted for publication on Differential Geometry and its Applications
Wolfgang Wüst (Hg.), Patrizier – Wege zur städtischen Oligarchie und zum Landadel. Süddeutschland im Städtevergleich. Referate der internationalen und interdisziplinären Tagung, Egloffstein’sches Palais zu Erlangen, Berlin (Peter Lang) 2018
Creators: name: Delle Luche, Jean-Dominique
Publisher: name: Francia-Recensio
Year: 2019

description: Wolfgang Wüst (Hg.), Patrizier – Wege zur städtischen Oligarchie und zum Landadel. Süddeutschland im Städtevergleich. Referate der internationalen und interdisziplinären Tagung, Egloffstein’sches Palais zu Erlangen, 7.–8. Oktober 2016. Unter Mitarbeit von Marc Holländer, Berlin (Peter Lang) 2018, 315 S., 38 Abb., ISBN 978-3-631-74325-6, EUR 49,95.
description: Francia-Recensio, 2019/2
Zosterodasys caudatus (Kahl, 1933) Jankowski 2007
Creators: name: Vďačný, Peter
name: Tirjaková, Eva
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Protozoa
Ciliophora
Nassophorea
Synhymeniida
Orthodonellidae
Zosterodasys
Zosterodasys caudatus

description: Zosterodasys caudatus (Kahl, 1933) Jankowski, 2007
(Figs 5 F, G)
 Chilodontopsis caudata Kahl, 1933: 66, fig. 6, 22; Kahl 1935: 826, fig. 152, 21 (taxonomic revision). Zosterodasys caudatus – Jankowski 2007: 729 (combining author).
 Diagnosis. Length about 60–80 µm in vivo. Body shape narrowly obovate with tail-like posterior end curved rightwards. Macronucleus ellipsoidal with a single globular micronucleus. A single contractile vacuole in midbody on left ventral side. Marine.
 Type locality. Sand from the saline bay of the town of Kiel, Germany.
 Type material. No type material available from Kahl’s specimens.
 Etymology. Not given in the original description. The Latin adjective caudat · us, - a, - um ([m, f, n]; tailed) obviously refers to the tail-like posterior body end.
 Remarks. Jankowski (2007) combined C. caudata with Zosterodasys, mandatorily changing the species group-name to masculine gender [Articles 30.2.4, 31.2 and 34.2 of the ICZN (1999)]. However, the generic home of this ciliate is doubtful because Kahl (1935) mentioned in his revision that the dorsal side is atypical as it is differentiated into a lateral flattened fringe with bristles and a dorsal hump very likely without cilia. Further, details on the structure and exact course of the synhymenium are not known. Full redescription and neotypification is recommended because several important data (i.e., details of somatic and oral ciliary pattern, number of nematodesmal rods, and morphometry) and type material are lacking.
description: Published as part of Vďačný, Peter & Tirjaková, Eva, 2012, Taxonomic revision of the ciliate genus Zosterodasys Deroux, 1978 (Protista: Ciliophora: Synhymeniida), pp. 34-58 in Zootaxa 3345 on page 54, DOI: 10.5281/zenodo.281497
Near Threshold Proton-Proton Fusion in Effective Field Theory
Creators: name: Chen, Jiunn-Wei
name: Liu, C. -P.
name: Yu, Shen-Hsi
Publisher: name: arXiv
Year: 2012
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The astrophysical S-factor for proton-proton fusion, S_11(E), is obtained with the nuclear matrix element analytically calculated in pionless effective field theory. To the third order, the zero-energy result S_11(0) and the first energy derivative S'_11(0) are found to be (3.99 \pm 0.14)* 10^-25 MeV b and S_11(0)*(11.3 \pm 0.1) MeV^-1, respectively; both consistent with the current adopted values. The second energy derivative is also calculated for the first time, and the result S"_11(0) = S_11(0)*(170 \pm 2) MeV^-2 contributes at the level of 0.5% to the fusion rate at the solar center, which is smaller than 1% as previously estimated.
description: Some typographical mistakes are fixed in this new version
Revisiting the Training of Logic Models of Protein Signaling Networks with a Formal Approach based on Answer Set Programming
Creators: name: Videla, Santiago
name: Guziolowski, Carito
name: Eduati, Federica
name: Thiele, Sven
name: Grabe, Niels
name: Saez-Rodriguez, Julio
name: Siegel, Anne
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantitative Methods (q-bio.QM)
subject: Artificial Intelligence (cs.AI)
subject: Computational Engineering, Finance, and Science (cs.CE)
subject: Machine Learning (cs.LG)
subject: FOS: Biological sciences
subject: FOS: Computer and information sciences

description: A fundamental question in systems biology is the construction and training to data of mathematical models. Logic formalisms have become very popular to model signaling networks because their simplicity allows us to model large systems encompassing hundreds of proteins. An approach to train (Boolean) logic models to high-throughput phospho-proteomics data was recently introduced and solved using optimization heuristics based on stochastic methods. Here we demonstrate how this problem can be solved using Answer Set Programming (ASP), a declarative problem solving paradigm, in which a problem is encoded as a logical program such that its answer sets represent solutions to the problem. ASP has significant improvements over heuristic methods in terms of efficiency and scalability, it guarantees global optimality of solutions as well as provides a complete set of solutions. We illustrate the application of ASP with in silico cases based on realistic networks and data.
Robert Bartlett (ed./transl.), Gerald of Wales, Instruction for a Ruler (De Principis Instructione), Oxford (University Press) 2018
Creators: name: Köhn, Rolf
Publisher: name: Francia-Recensio
Year: 2019

description: Robert Bartlett (ed./transl.), Gerald of Wales, Instruction for a Ruler (De Principis Instructione), Oxford (University Press) 2018, LXX–801 p. (Oxford Medieval Texts), ISBN 978-0-19-873862-6, GBP 125,00.
description: Francia-Recensio, 2019/2
The Cytokinin Status of the Epidermis Regulates Aspects of Vegetative and Reproductive Development in Arabidopsis thaliana
Creators: name: Werner, Sören
name: Bartrina, Isabel
name: Novák, Ondřej
name: Strnad, Miroslav
name: Werner, Tomáš
name: Schmülling, Thomas
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: cytokinin
subject: epidermis
subject: Arabidopsis
subject: shoot growth
subject: seed yield
subject: developmental transitions
subject: 500 Naturwissenschaften und Mathematik::580 Pflanzen (Botanik)::580 Pflanzen (Botanik)

description: The epidermal cell layer of plants has important functions in regulating plant growth and development. We have studied the impact of an altered epidermal cytokinin metabolism on Arabidopsis shoot development. Increased epidermal cytokinin synthesis or breakdown was achieved through expression of the cytokinin synthesis gene LOG4 and the cytokinin-degrading CKX1 gene, respectively, under the control of the epidermis-specific AtML1 promoter. During vegetative growth, increased epidermal cytokinin production caused an increased size of the shoot apical meristem and promoted earlier flowering. Leaves became larger and the shoots showed an earlier juvenile-to-adult transition. An increased cytokinin breakdown had the opposite effect on these phenotypic traits indicating that epidermal cytokinin metabolism can be a factor regulating these aspects of shoot development. The phenotypic consequences of abbreviated cytokinin signaling in the epidermis achieved through expression of the ARR1-SRDX repressor were generally milder or even absent indicating that the epidermal cytokinin acts, at least in part, cell non-autonomously. Enhanced epidermal cytokinin synthesis delayed cell differentiation during leaf development leading to an increased cell proliferation and leaf growth. Genetic analysis showed that this cytokinin activity was mediated mainly by the AHK3 receptor and the transcription factor ARR1. We also demonstrate that epidermal cytokinin promotes leaf growth in a largely cell-autonomous fashion. Increased cytokinin synthesis in the outer layer of reproductive tissues and in the placenta enhanced ovule formation by the placenta and caused the formation of larger siliques. This led to a higher number of seeds in larger pods resulting in an increased seed yield per plant. Collectively, the results provide evidence that the cytokinin metabolism in the epidermis is a relevant parameter determining vegetative and reproductive plant growth and development.
On the Performance Bound of Sparse Estimation with Sensing Matrix Perturbation
Creators: name: Tang, Yujie
name: Chen, Laming
name: Gu, Yuantao
Publisher: name: arXiv
Year: 2012
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: This paper focusses on the sparse estimation in the situation where both the the sensing matrix and the measurement vector are corrupted by additive Gaussian noises. The performance bound of sparse estimation is analyzed and discussed in depth. Two types of lower bounds, the constrained Cramér-Rao bound (CCRB) and the Hammersley-Chapman-Robbins bound (HCRB), are discussed. It is shown that the situation with sensing matrix perturbation is more complex than the one with only measurement noise. For the CCRB, its closed-form expression is deduced. It demonstrates a gap between the maximal and nonmaximal support cases. It is also revealed that a gap lies between the CCRB and the MSE of the oracle pseudoinverse estimator, but it approaches zero asymptotically when the problem dimensions tend to infinity. For a tighter bound, the HCRB, despite of the difficulty in obtaining a simple expression for general sensing matrix, a closed-form expression in the unit sensing matrix case is derived for a qualitative study of the performance bound. It is shown that the gap between the maximal and nonmaximal cases is eliminated for the HCRB. Numerical simulations are performed to verify the theoretical results in this paper.
description: 32 pages, 8 Figures, 1 Table
Treatment with the calcineurin inhibitor and immunosuppressant cyclosporine A impairs sensorimotor gating in Dark Agouti rats
Creators: name: Brosda, Jan
name: Becker, Thorsten
name: Richter, Mathis
name: Jakobs, Marie
name: Horbelt, Tina
name: Bendix, Ivo
name: Luckemann, Laura
name: Schedlowski, Manfred
name: Hadamitzky, Martin
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: Cyclosporine A
subject: Calcineurin
subject: Prepulse inhibition
subject: Sensorimotor gating
subject: Drug side effects
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Rationale Calcineurin is a protein regulating cytokine expression in T lymphocytes and calcineurin inhibitors such as cyclosporine A (CsA) are widely used for immunosuppressive therapy. It also plays a functional role in distinct neuronal processes in the central nervous system. Disturbed information processing as seen in neuropsychiatric disorders is reflected by deficient sensorimotor gating, assessed as prepulse inhibition (PPI) of the acoustic startle response (ASR). Objective Patients who require treatment with immunosuppressive drugs frequently display neuropsychiatric alterations during treatment with calcineurin inhibitors. Importantly, knockout of calcineurin in the forebrain of mice is associated with cognitive impairments and symptoms of schizophrenia-like psychosis as seen after treatment with stimulants. Methods The present study investigated in rats effects of systemic acute and subchronic administration of CsA on sensorimotor gating. Following a single injection with effective doses of CsA, adult healthy male Dark Agouti rats were tested for PPI. For subchronic treatment, rats were injected daily with the same doses of CsA for 1 week before PPI was assessed. Since calcineurin works as a modulator of the dopamine pathway, activity of the enzyme tyrosine hydroxylase was measured in the prefrontal cortex and striatum after accomplishment of the study. Results Acute and subchronic treatment with the calcineurin inhibitor CsA disrupted PPI at a dose of 20 mg/kg. Concomitantly, following acute CsA treatment, tyrosine hydroxylase activity was reduced in the prefrontal cortex, which suggests that dopamine synthesis was downregulated, potentially reflecting a stimulatory impact of CsA on this neurotransmitter system. Conclusions The results support experimental and clinical evidence linking impaired calcineurin signaling in the central nervous system to the pathophysiology of neuropsychiatric symptoms. Moreover, these findings suggest that therapy with calcineurin inhibitors may be a risk factor for developing neurobehavioral alterations as observed after the abuse of psychomotor stimulant drugs.
Lattice methods for strongly interacting many-body systems
Creators: name: Drut, Joaquín E.
name: Nicholson, Amy N.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: High Energy Physics - Lattice (hep-lat)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Lattice field theory methods, usually associated with non-perturbative studies of quantum chromodynamics, are becoming increasingly common in the calculation of ground-state and thermal properties of strongly interacting non-relativistic few- and many-body systems, blurring the interfaces between condensed matter, atomic and low-energy nuclear physics. While some of these techniques have been in use in the area of condensed matter physics for a long time, others, such as hybrid Monte Carlo and improved effective actions, have only recently found their way across areas. With this topical review, we aim to provide a modest overview and a status update on a few notable recent developments. For the sake of brevity we focus on zero-temperature, non-relativistic problems. After a short introduction, we lay out some general considerations and proceed to discuss sampling algorithms, observables, and systematic effects. We show selected results on ground- and excited-state properties of fermions in the limit of unitarity. The appendix contains details on group theory on the lattice.
description: 64 pages, 32 figures; topical review for J. Phys. G; replaced with published version
Titel
Creators: name: Redaktion, Die
Publisher: name: Funde und Ausgrabungen im Bezirk Trier
Year: 2019

description: -
description: Funde und Ausgrabungen im Bezirk Trier, Bd. 43 (2011): Funde und Ausgrabungen im Bezirk Trier : Aus der Arbeit des Rheinischen Landesmuseums Trier
Fidelity susceptibility of one-dimensional models with twisted boundary conditions
Creators: name: Thakurathi, Manisha
name: Sen, Diptiman
name: Dutta, Amit
Publisher: name: arXiv
Year: 2012
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Recently it has been shown that the fidelity of the ground state of a quantum many-body system can be used to detect its quantum critical points (QCPs). If g denotes the parameter in the Hamiltonian with respect to which the fidelity is computed, we find that for one-dimensional models with large but finite size, the fidelity susceptibility χ_F can detect a QCP provided that the correlation length exponent satisfies ν< 2. We then show that χ_F can be used to locate a QCP even if ν\ge 2 if we introduce boundary conditions labeled by a twist angle Nθ, where N is the system size. If the QCP lies at g = 0, we find that if N is kept constant, χ_F has a scaling form given by χ_F \sim θ^{-2/ν} f(g/θ^{1/ν}) if θ\ll 2π/N. We illustrate this both in a tight-binding model of fermions with a spatially varying chemical potential with amplitude h and period 2q in which ν= q, and in a XY spin-1/2 chain in which ν= 2. Finally we show that when q is very large, the model has two additional QCPs at h = \pm 2 which cannot be detected by studying the energy spectrum but are clearly detected by χ_F. The peak value and width of χ_F seem to scale as non-trivial powers of q at these QCPs. We argue that these QCPs mark a transition between extended and localized states at the Fermi energy.
description: 12 pages, 10 figures; made some changes in response to referees; this is the published version
Hepatitis E virus: Efficacy of pasteurization of plasma‐derived VWF/FVIII concentrate determined by pig bioassay
Creators: name: Dähnert, Lisa
name: Schlosser, Josephine
name: Fast, Christine
name: Fröhlich, Andreas
name: Gröner, Albrecht
name: Lange, Elke
name: Roth, Nathan J.
name: Schäfer, Wolfram
name: Schröder, Charlotte
name: Eiden, Martin
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: hepatitis E virus
subject: inactivation
subject: infectivity
subject: pasteurization
subject: plasma product
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Background Hepatitis E virus (HEV) is the leading cause of acute hepatitis throughout the world. Increasing blood component transfusion-associated HEV infections highlight the need for reliable virus inactivation procedures for plasma derivatives from pooled plasma donations. Study Design and Methods An animal infection study was conducted to evaluate the efficiency of HEV inactivation by pasteurization during the manufacturing process of the von Willebrand Factor/Factor VIII (VWF/FVIII) concentrate Haemate P/Humate-P (CSL Behring, Marburg, Germany). For this purpose, groups of pigs were inoculated with stabilized VWF/FVIII intermediate spiked with HEV-positive liver homogenate and exposed to increasing incubation times of 0, 3, 6, and 10 h at 60 degrees C. Animals were evaluated for virus replication over 27 days and in a subsequent trial over 92 days. Results Virus replication was detected in animals up to the 6-h pasteurization group. In contrast, pasteurization for 10 h did not reveal virus detection when the observation period was 27 days. In an additional experiment using the 10-h pasteurized material, two individuals started virus excretion and seroconverted when the observation period was extended to 92 days. Based on the total infection rate (2 of 12) of the animals inoculated with the sample pasteurized for 10 h, a virus reduction factor of at least 4.7 log(10) is calculated. Conclusion This study demonstrates that pasteurization at 60 degrees C for 10 h of an HEV-positive plasma derivative leads to the effective reduction of infectivity, resulting in a VWF/FVIII product with an appropriate margin of safety for HEV.
Zosterodasys numerosus (Ozaki & Yagiu, 1941) Jankowski 2007
Creators: name: Vďačný, Peter
name: Tirjaková, Eva
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Protozoa
Ciliophora
Nassophorea
Synhymeniida
Orthodonellidae
Zosterodasys
Zosterodasys numerosus

description: Zosterodasys numerosus (Ozaki & Yagiu, 1941) Jankowski, 2007
(Fig. 8 J)
 Chilodontopsis nemerosa – Wang et al. 2012: 46, 49, 51 [incorrect subsequent spelling and therefore unavailable according to the Articles 33.3 and 33.5 of the ICZN (1999)].
 Chilodontopsis numerosa Ozaki & Yagiu, 1941: 173, fig. 22.
 Zosterodasys numerosa – Jankowski 2007: 729 (combining author).
 Zosterodasys transverses – Gong et al. 2009: 341 [18S rRNA gene sequence of a South Korean population; incorrect subsequent spelling and therefore unavailable according to the Articles 33.3 and 33.5 of the ICZN (1999)]; Wang et al. 2012: 50, figs 5–10, 19–26 (morphological description of the South Korean population; very likely a misidentification).
 Diagnosis. Size about 200–250 × 55–70 µm in vivo (?). Body shape narrowly obovate with left margin anteriorly indistinctly projecting. Macronucleus ellipsoidal. Many scattered contractile vacuoles. Marine.
 Type locality. Under cyanobacterial layer in saltwater ditches near the Onomiti Channel, Japan.
 Type material. Deposition of type material not mentioned in the original paper.
 Etymology. Not given in the original description. The Latin adjective numeros · us, - a, - um ([m, f, n]; numerous) obviously refers to the numerous contractile vacuoles.
 Remarks. Jankowski (2007) combined C. numerosa with Zosterodasys, but did not change the species groupname to masculine gender. Thus, according to the Articles 30.2.4, 31.2 and 34.2 of the ICZN (1999), we mandatorily change numerosa to numerosus because Zosterodasys is masculine gender. We tentatively suggest to affiliating “ Z. transverses ” described by Wang et al. (2012) from a littoral rocky pond (30‰ salinity) near Incheon in South Korea with Z. numerosus. Both have a similar body size (160–400 µm in “ Z. transverses ” and 200–250 µm in Z. numerosus), an oblong macronucleus and many scattered contractile vacuoles. Moreover, both live in East Asian saltwater environments. Thus, we recommend to neotypify Z. numerosus with the South Korean population because several important data (i.e., details of somatic and oral ciliary pattern, number of nematodesmal rods and ciliary rows as well as morphometry) and type material are not available from its original description by Ozaki & Yagiu (1941).
description: Published as part of Vďačný, Peter & Tirjaková, Eva, 2012, Taxonomic revision of the ciliate genus Zosterodasys Deroux, 1978 (Protista: Ciliophora: Synhymeniida), pp. 34-58 in Zootaxa 3345 on pages 54-55, DOI: 10.5281/zenodo.281497
Electronic structure, disconnected Fermi surfaces and antiferromagnetism in the layered pnictide superconductor Na$_x$Ba$_{1-x}$Ti$_2$Sb$_2$O
Creators: name: Singh, D. J.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We report electronic structure calculations for BaTi$_2$Sb$_2$O and discuss the results in relation to the observed superconductivity of this material when hole doped with Na. The Fermi surface shows several sheets. These include a nested nearly 2D cylinder. There are also two sheets, which are three dimensional, in spite of the layered crystal structure. A magnetic instability associated with Fermi surface nesting is found. A sign-changing s-wave state, different from the one in the Fe-based superconductors, is predicted within a scenario of spin-fluctuation mediated superconductivity.
description: Typos corrected. References updated
Spatiotemporal and Wavenumber Resolved Bicoherence at the Low to High Confinement Transition in the TJ-II Stellarator
Creators: name: van Milligen, B. Ph.
name: Estrada, T.
name: Hidalgo, C.
name: Happel, T.
name: Ascasíbar, E.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: Plasma turbulence is studied using Doppler reflectometry at the TJ-II stellarator. By scanning the tilt angle of the probing beam, different values of the perpendicular wave numbers are probed at the reflection layer. In this way, the interaction between zonal flows and turbulence is reported with (a) spatial, (b) temporal, and (c) wavenumber resolution for the first time in any magnetic confinement fusion device. We report measurements of the bicoherence across the Low to High (L--H) confinement transition at TJ-II. We examine both fast transitions and slow transitions characterized by an intermediate (I) phase. The bicoherence, understood to reflect the non-linear coupling between the perpendicular velocity (zonal flow) and turbulence amplitude, is significantly enhanced in a time window of several tens of ms around the time of the L--H transition. It is found to peak at a specific radial position (slightly inward from the radial electric field shear layer in H mode), and is associated with a specific perpendicular wave number ($k_\perp \simeq 6-12$ cm$^{-1}$, $k_\perp ρ_s \simeq 0.8-2$). In all cases, the bicoherence is due to the interaction between high frequencies ($\simeq 1$ MHz) and a rather low frequency ($\lesssim 50$ kHz), as expected for a zonal flow.
description: 11 pages, 3 figures
Allosteric coupling and biased agonism in G protein‐coupled receptors
Creators: name: Bock, Andreas
name: Bermudez, Marcel
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: allosteric coupling
subject: biased agonism
subject: biased ligands
subject: drug discovery
subject: G protein‐coupled receptors
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: G protein-coupled receptors (GPCRs) are essential cell membrane signaling molecules and represent the most important class of drug targets. Some signaling pathways downstream of a GPCR may be responsible for drug adverse effects, while others mediate therapeutic efficacy. Biased ligands preferentially activate only a subset of all GPCR signaling pathways. They hold great potential to become next-generation GPCR drugs with less side effects due to their potential to exclusively activate desired signaling pathways. However, the molecular basis of biased agonism is poorly understood. GPCR activation occurs through allosteric coupling, the propagation of conformational changes from the extracellular ligand-binding pocket to the intracellular G protein-binding interface. Comparison of GPCR structures in complex with G proteins or beta-arrestin reveals that intracellular transducer coupling results in closure of the ligand-binding pocket trapping the agonist inside its binding site. Allosteric coupling appears to be transducer-specific offering the possibility of harnessing this mechanism for the design of biased ligands. Here, we review the biochemical, pharmacological, structural, and biophysical evidence for allosteric coupling and delineate that biased agonism should be a consequence of preferential allosteric coupling from the ligand-binding pocket to one transducer-binding site. As transducer binding leads to large structural rearrangements in the extracellular ligand-binding pocket, we survey biased ligands with an extended binding mode that interact with extracellular receptor domains. We propose that biased ligands use ligand-specific triggers inside the binding pocket that are relayed through preferential allosteric coupling to a specific transducer, eventually leading to biased signaling.
Übersicht über vorgeschichtliche Veröffentlichungen des letzten Jahres im Gebiet der sächsischen und thüringischen Länder
Creators: name: Höfer, Paul
Publisher: name: Jahresschrift für mitteldeutsche Vorgeschichte
Year: 2019

description: -
description: Jahresschrift für mitteldeutsche Vorgeschichte, Bd. 1 (1902): Jahresschrift für Mitteldeutsche Vorgeschichte
Periodic Bedrock Ridges at the ExoMars 2022 Landing Site: Evidence for a Changing Wind Regime
Creators: name: Silvestro, S.
name: Pacifici, A.
name: Salese, F.
name: Vaz, D. A.
name: Neesemann, Alicia
name: Tirsch, D.
name: Popa, C. I.
name: Pajola, M.
name: Franzese, G.
name: Mongelluzzo, G.
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: ExoMars
subject: landing
subject: Mars
subject: Oxia
subject: ripples
subject: wind
subject: 500 Naturwissenschaften und Mathematik::520 Astronomie::523 Einzelne Himmelskörper und Himmelsphänomene

description: Wind-formed features are abundant in Oxia Planum (Mars), the landing site of the 2022 ExoMars mission, which shows geological evidence for a past wet environment. Studies of aeolian bedforms at the landing site were focused on assessing the risk for rover trafficability, however their potential in recording climatic fluctuations has not been explored. Here we show that the landing site experienced multiple climatic changes in the Amazonian, which are recorded by an intriguing set of ridges that we interpret as Periodic Bedrock Ridges (PBRs). Clues for a PBR origin result from ridge regularity, defect terminations, and the presence of preserved megaripples detaching from the PBRs. PBR orientation differs from superimposed transverse aeolian ridges pointing toward a major change in wind regime. Our results provide constrains on PBR formation mechanisms and offer indications on paleo winds that will be crucial for understanding the landing site geology.
Irmgart Geiger, Treibverzierte Bronzerundschilde der italischen Eisenzeit
Creators: name: Stary, Peter F.
Publisher: name: Bonner Jahrbücher
Year: 2019

description: Rezension zu: Irmgart Geiger, Treibverzierte Bronzerundschilde der italischen Eisenzeit. Prähistorische Bronzefunde, Abteilung III, Band 1. Franz Steiner Verlag, Stuttgart 1994. VIII, 129 Seiten, 55 Textabbildungen, 114 Tafeln
description: Bonner Jahrbücher, Bd. 196.1996(1997): Bonner Jahrbücher
The horizontal branch luminosity vs metallicity in M31 globular clusters
Creators: name: Federici, Luciana
name: Cacciari, Carla
name: Bellazzini, Michele
name: Pecci, Flavio Fusi
name: Galleti, Silvia
name: Perina, Sibilla
Publisher: name: arXiv
Year: 2012
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Thanks to the outstanding capabilites of the HST, our current knowledge about the M31 globular clusters (GCs) is similar to our knowledge of the Milky Way GCs in the 1960s-1970s, which set the basis for studying the halo and galaxy formation using these objects as tracers, and established their importance in defining the cosmic distance scale. We intend to derive a new calibration of the M_V(HB)-[Fe/H] relation by exploiting the large photometric database of old GCs in M31 in the HST archive. We collected the BVI data for 48 old GCs in M31 and analysed them by applying the same methods and procedures to all objects. We obtained a set of homogeneous colour-magnitude diagrams (CMDs) that were best-fitted with the fiducial CMD ridge lines of selected Milky Way template GCs. Reddening, metallicity, Horizontal Branch (HB) luminosity and distance were determined self-consistently for each cluster. There are three main results of this study: i) the relation M_V(HB)=(0.25+/-0.02)[Fe/H]+(0.89+/-0.03), which is obtained from the above parameters and is calibrated on the distances of the template Galactic GCs; ii) the distance modulus to M31 of (m-M)_0=24.42+/-0.06 mag, obtained by normalising this relation at the reference value of [Fe/H]=-1.5 to a similar relation using V_0(HB). This is the first determination of the distance to M31 based on the characteristics of its GC system which is calibrated on Galactic GCs; iii) the distance to the Large Magellanic Cloud (LMC), which is estimated to be 18.54+/-0.07 mag as a consequence of the previous results. These values agree excellently with the most recent estimate based on HST parallaxes of Galactic Cepheid and RR Lyrae stars, as well as with recent methods.
description: 13 pages, 6 figures, 2 tables; typos corrected; added a reference for section 4. Accepted for publication in Astronomy&Astrophysics
Saving Grace: The Health Intervention of the Black Church During the AIDS Crisis in Oakland, California, 1985-2010
Creators: name: French, Daniel
Publisher: name: University of Chicago
Year: 2023
Subjects: subject: African Anerican church
subject: Healthcare Disparity
subject: Sexuality
subject: AIDS
subject: Black church
subject: Allen Temple Baptist Church
subject: Oakland California

description: Systemic features such as scientific racism, long-standing distrust of the medical establishment, and overall neglect of African American healthcare concerns created challenging circumstances for blacks during the AIDS crisis. This, coupled with the stigma of being gay and black, rendered African Americans invisible and vulnerable during the AIDS epidemic from the 1980s to the 2000s in Oakland, California. The impact would have been more significant if not for the black community in Oakland, which rallied around itself to improve the plight of people of color living with the disease. Faith-based organizations, such as the black church, filled in gaps through community outreach, education, health fairs, and housing, which proved to be a “saving grace” to people of color in Oakland. Using oral interviews, local and black newspapers, broadcast media, newsletters, church, and AIDS organizations archives, academic articles, and books, this paper illustrates the effectiveness of the black church in advocating for those marginalized by HIV/AIDS during the late 1980s to the 2000s in Oakland, California. Due to their efforts, this paper demonstrate, the religious community eventually came to view healthcare as a civil right.