cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Programmed Hydrolysis in Designing Paclitaxel Prodrug for Nanocarrier Assembly
Creators: name: Liu, F.
name: Fu, Q.
name: Ma, Y.
name: Wang, Y.
name: Zhang, D.
name: Fallon, J. K.
name: Yang, X.
name: Liu, D.
name: He, Z.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Nanocarriers delivering prodrugs are a way of improving in vivo effectiveness and efficiency. For therapeutic efficacy, the prodrug must hydrolyze to its parent drug after administration. Based on the fact that the hydrolysis is impeded by steric hindrance and improved by sufficient polarity, in this study, we proposed the PTX-S-S-VE, the conjugation of paclitaxel (PTX) to vitamin E (VE) through a disulfide bridge. This conjugate possessed the following advantages: first, it can be encapsulated in the VE/VE2-PEG2000/water nanoemulsions because of favorable hydrophobic interactions; second, the nanoemulsions had a long blood circulation time; finally, the concentrated glutathione in the tumor microenvironment could cleave the disulfide bond to weaken the steric hindrance and increase the polarity, promoting the hydrolysis to PTX and increasing the anticancer activity. It was demonstrated in vitro that the hydrolysis of PTX-S-S-VE was enhanced and the cytotoxicity was increased. In addition, PTX-S-S-VE had greater anticancer activity against the KB-3-1 cell line tumor xenograft and the tumor size was smaller after the 4th injection. The present result suggests a new way, use of reduction, to improve the in vivo anticancer activity of a prodrug for nanocarrier delivery by unshielding the ester bond and taking off the steric block.
Rap2B promotes proliferation, migration and invasion of human breast cancer through calcium-related ERK1/2 signaling pathway
Creators: name: Tang, Juangjuan
name: Di, Jiehui
name: Zhang, Yanping
name: Cheng, Qian
name: Yang, Jing
name: Cao, Wenjia
name: Zheng, Junnian
name: Huang, Hui
name: Bai, Jin
name: Lu, Zheng
name: Qu, Debao
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Rap2B, a member of GTP-binding proteins, is widely upregulated in many types of tumors and promotes migration and invasion of human suprarenal epithelioma. However, the function of Rap2B in breast cancer is unknown. Expression of Rap2B was examined in breast cancer cell lines and human normal breast cell line using Western blot analysis. Using the CCK-8 cell proliferation assay, cell cycle analysis, and transwell migration assay, we also elucidated the role of Rap2B in breast cancer cell proliferation, migration, and invasion. Results showed that the expression of Rap2B is higher in tumor cells than in normal cells. Flow cytometry and Western blot analysis revealed that Rap2B elevates the intracellular calcium level and further promotes extracellular signal-related kinase (ERK) 1/2 phosphorylation. By contrast, calcium chelator BAPTM/AM and MEK inhibitor (U0126) can reverse Rap2B-induced ERK1/2 phosphorylation. Furthermore, Rap2B knockdown inhibits cell proliferation, migration, and invasion abilities via calcium related-ERK1/2 signaling. In addition, overexpression of Rap2B promotes cell proliferation, migration and invasion abilities, which could be neutralized by BAPTM/AM and U0126. Taken together, these findings shed light on Rap2B as a therapeutic target for breast cancer.
Additional file 8 of Functional changes in the oral microbiome after use of fluoride and arginine containing dentifrices: a metagenomic and metatranscriptomic study
Creators: name: Carda-Diéguez, Miguel
name: Moazzez, Rebecca
name: Mira, Alex
Publisher: name: figshare
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics

description: Additional file 8: Additional Figure 7. Metagenomic and metatranscriptomic functional profiles correlation. The overlap between over-represented (MTG) and over-expressed (MTT) genes are represented as Venn diagrams. The genes that were over-represented and over-expressed are shown in the overlapping region for each comparison: Baseline vs Fluoride (left panel) and Fluoride vs Fluoride+Arg (right panel).
Gapped Domain Walls, Gapped Boundaries and Topological Degeneracy
Creators: name: Lan, Tian
name: Wang, Juven
name: Wen, Xiao-Gang
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: Category Theory (math.CT)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: Gapped domain walls, as topological line defects between 2+1D topologically ordered states, are examined. We provide simple criteria to determine the existence of gapped domain walls, which apply to both Abelian and non-Abelian topological orders. Our criteria also determine which 2+1D topological orders must have gapless edge modes, namely which 1+1D global gravitational anomalies ensure gaplessness. Furthermore, we introduce a new mathematical object, the tunneling matrix $\mathcal W$, whose entries are the fusion-space dimensions $\mathcal W_{ia}$, to label different types of gapped domain walls. By studying many examples, we find evidence that the tunneling matrices are powerful quantities to classify different types of gapped domain walls. Since a gapped boundary is a gapped domain wall between a bulk topological order and the vacuum, regarded as the trivial topological order, our theory of gapped domain walls inclusively contains the theory of gapped boundaries. In addition, we derive a topological ground state degeneracy formula, applied to arbitrary orientable spatial 2-manifolds with gapped domain walls, including closed 2-manifolds and open 2-manifolds with gapped boundaries.
description: 5+9 pages, 3 figures, updated references, fixed typos and refinements, added proof for equivalence to Lagrangian subgroups in Abelian cases
Remote Control of Tissue Interactions via Engineered Photo-switchable Cell Surfaces
Creators: name: Dutta, Debjit
name: Luo, Wei
name: Pulsipher, Abigail
name: Lamb, Brian M.
name: Yousaf, Muhammad N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: We report a general cell surface molecular engineering strategy via liposome fusion delivery to create a dual photo-active and bio-orthogonal cell surface for remote controlled spatial and temporal manipulation of microtissue assembly and disassembly. Cell surface tailoring of chemoselective functional groups was achieved by a liposome fusion delivery method and quantified by flow cytometry and characterized by a new cell surface lipid pull down mass spectrometry strategy. Dynamic co-culture spheroid tissue assembly in solution and co-culture tissue multilayer assembly on materials was demonstrated by an intercellular photo-oxime ligation that could be remotely cleaved and disassembled on demand. Spatial and temporal control of microtissue structures containing multiple cell types was demonstrated by the generation of patterned multilayers for controlling stem cell differentiation. Remote control of cell interactions via cell surface engineering that allows for real-time manipulation of tissue dynamics may provide tools with the scope to answer fundamental questions of cell communication and initiate new biotechnologies ranging from imaging probes to drug delivery vehicles to regenerative medicine, inexpensive bioreactor technology and tissue engineering therapies.
Additional file 1 of The 14-item short health anxiety inventory (SHAI-14) used as a screening tool: appropriate interpretation and diagnostic accuracy of the Swedish version
Creators: name: Österman, Susanna
name: Axelsson, Erland
name: Lindefors, Nils
name: Hedman-Lagerlöf, Erik
name: Hedman-Lagerlöf, Maria
name: Kern, Dorian
name: Svanborg, Cecilia
name: Ivanov, Volen Z.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: Computational Biology

description: Additional file 1.
Small tRNA-derived RNAs are increased and more abundant than microRNAs in chronic hepatitis B and C
Creators: name: Honda, Masao
name: Kaneko, Shuichi
name: Yamane, Daisuke
name: Shirasaki, Takayoshi
name: Sethupathy, Praveen
name: Selitsky, Sara R.
name: Baran-Gale, Jeanette
name: Fannin, Emily E.
name: Guerra, Bernadette
name: Masaki, Takahiro
name: Lemon, Stanley M.
name: Lanford, Robert E.
name: Shimakami, Tetsuro
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Persistent infections with hepatitis B virus (HBV) or hepatitis C virus (HCV) account for the majority of cases of hepatic cirrhosis and hepatocellular carcinoma (HCC) worldwide. Small, non-coding RNAs play important roles in virus-host interactions. We used high throughput sequencing to conduct an unbiased profiling of small (14-40 nts) RNAs in liver from Japanese subjects with advanced hepatitis B or C and hepatocellular carcinoma (HCC). Small RNAs derived from tRNAs, specifically 30–35 nucleotide-long 5′ tRNA-halves (5′ tRHs), were abundant in non-malignant liver and significantly increased in humans and chimpanzees with chronic viral hepatitis. 5′ tRH abundance exceeded microRNA abundance in most infected non-cancerous tissues. In contrast, in matched cancer tissue, 5′ tRH abundance was reduced, and relative abundance of individual 5′ tRHs was altered. In hepatitis B-associated HCC, 5′ tRH abundance correlated with expression of the tRNA-cleaving ribonuclease, angiogenin. These results demonstrate that tRHs are the most abundant small RNAs in chronically infected liver and that their abundance is altered in liver cancer.
Law of Conservation of Dimensional Magnitude
Creators: name: Dutta, Sayandeep
Publisher: name: Zenodo
Year: 2023
Subjects: hypothesis
dimensions
law
wormholes

description: The law of conservation of dimensional magnitude is a hypothetical law that can be used in the study of wormholes and discoveries of more dimensions. Law of conservation of dimensional magnitude is derived and similar to the concept of law of conservation of mass for 3D bodies. The ideology comes from the topic that supposedly if the length of a 3D body decreases then the breadth will increase height being the same till the mass of the body remains same.
РЕГЛАМЕНТАЦИЯ ПРАВООТНОШЕНИЙ ПО ВЫПОЛНЕНИЮ ПОДРЯДНЫХ РАБОТ ДЛЯ УДОВЛЕТВОРЕНИЯ НУЖД ОРГАНОВ ВНУТРЕННИХ ДЕЛ: CОВЕТСКИЙ ЭТАП
Creators: name: Абдуллаев Р.Р.
name: Миннигулова Д.Б.
Publisher: name: Образование и право
Year: 2022
Subjects: подэтапы регламентации советских государственных подрядных правоотношений
подрядные работы для удовлетворения нужд органов внутренних дел
договор подряда на капитальное строительство
милиция.

description: В статье освещается историко-правовой генезис советского законодательства, регламентирующего выполнение подрядных работ для нужд отечественных органов внутренних дел, представлена авторская концепция периодизации выстраивания советских государственных подрядных правоотношений во взаимосвязи с развитием правового регулирования и организацией милицейского ведомства указанной эпохи. Анализ советских нормативных правовых актов позволяет резюмировать: подрядные правоотношения для государственных нужд главным образом складывались между государственными органами, учреждениями и предприятиями, опирались на административно-командную систему, плановую экономику и реализовывались за счёт хозяйственного или подрядного способов. Договор подряда на капитальное строительство являлся ключевым документом, регулирующим взаимоотношения между государственным заказчиком и подрядчиком, заключавшийся на плановой основе без проведения публичных торгов.
Swap Test-based Characterization of Quantum Processes in Universal Quantum Computers
Creators: name: Ripper, Pedro
name: Amaral, Gustavo
name: Temporão, Guilherme
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum Computing has been presenting major developments in the last few years, unveiling systems with a increasing number of qubits. However, unreliable quantum processes in universal quantum computers still represent one of the the greatest challenges to be overcome. Such obstacle has its source on noisy operations and interactions with the environment which introduce decoherence to a quantum system. In this article we verify whether a tool called Swap Test is able to identify decoherence. Our experimental results demonstrate that the Swap Test can be employed as an alternative to a full Quantum Process Tomography, with the advantage of not destroying the qubit under test, under certain circumstances, as long as some modifications are introduced.
СОСТЯЗАТЕЛЬНОСТЬ И РАВНОПРАВИЕ СТОРОН В КОНСТИТУЦИОННОМ ПРАВОСУДИИ: ОБЩИЕ И СПЕЦИФИЧЕСКИЕ ХАРАКТЕРИСТИКИ
Creators: name: Соболева Е.А.
Publisher: name: Образование и право
Year: 2022
Subjects: Состязательность и равноправие сторон
конституционное правосудие
Конституционный Суд РФ
конституционный нормоконтроль
принципы конституционного правосудия.

description: В статье предпринята попытка рассмотреть особенности нормативного содержания и реализации принципа состязательности и равноправия сторон в конституционном судебном процессе. С учетом специфики конституционного правосудия и особой юридической природы Конституционного Суда Российской Федерации механизм реализации такого принципа обладает существенной спецификой, что связано с особым (публичным) характером споров в конституционном судопроизводстве, статусом участников судебного процесса, с процессуальными особенностями разрешения отдельных категорий дел в конституционном судопроизводстве. Автором предлагается конкретизировать правовое регулирование и усовершенствовать механизм реализации данного принципа, в том числе за счет усиления активной роли Конституционного Суда в реализации принципа состязательности и равноправия сторон.
The Acyclic Retinoid Peretinoin Inhibits Hepatitis C Virus Replication and Infectious Virus Release in Vitro
Creators: name: Murakami, Seishi
name: Yamane, Daisuke
name: Shirasaki, Takayoshi
name: Honda, Masao
name: Shiomoto, Takayuki
name: Kaneko, Shuichi
name: Takabatake, Riuta
name: Liu, Fanwei
name: Lemon, Stanley M.
name: Funaki, Masaya
name: Shimakami, Tetsuro
name: Murai, Kazuhisa
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Clinical studies suggest that the oral acyclic retinoid Peretinoin may reduce the recurrence of hepatocellular carcinoma (HCC) following surgical ablation of primary tumours. Since hepatitis C virus (HCV) infection is a major cause of HCC, we assessed whether Peretinoin and other retinoids have any effect on HCV infection. For this purpose, we measured the effects of several retinoids on the replication of genotype 1a, 1b, and 2a HCV in vitro. Peretinoin inhibited RNA replication for all genotypes and showed the strongest antiviral effect among the retinoids tested. Furthermore, it reduced infectious virus release by 80–90% without affecting virus assembly. These effects could be due to reduced signalling from lipid droplets, triglyceride abundance, and the expression of mature sterol regulatory element-binding protein 1c and fatty acid synthase. These negative effects of Peretinoin on HCV infection may be beneficial in addition to its potential for HCC chemoprevention in HCV-infected patients.
Anti-parity-time symmetry hidden in a damping linear resonator
Creators: name: Xu, Xun-Wei
name: Liao, Jie-Qiao
name: Jing, Hui
name: Kuang, Le-Man
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Phase transition from the over-damping to under-damping states is a ubiquitous phenomenon in physical systems. However, what kind of symmetry is broken associated with this phase transition remains unclear. Here, we discover that this phase transition is determined by an anti-parity-time (anti-$\mathcal{PT}$) symmetry hidden in a single damping linear resonator, which is significantly different from the conventional anti-$\mathcal{PT}$-symmetric systems with two or more modes. We show that the breaking of the anti-$\mathcal{PT}$ symmetry yields the phase transition from the over-damping to under-damping states, with an exceptional point (EP) corresponding to the critical-damping state. Moreover, we propose an optomechanical scheme to show this anti-$\mathcal{PT}$ symmetry breaking by using the optical spring effect in a quadratic optomechanical system. We also suggest an optomechanical sensor with the sensitivity enhanced significantly around the EPs for the anti-$\mathcal{PT}$ symmetry breaking. Our work unveils the anti-$\mathcal{PT}$ symmetry hidden in damping oscillations and hence opens up new possibilities for exploiting wide anti-$\mathcal{PT}$ symmetry applications in single damping linear resonators.
description: 12 pages, 6 figures, Research Highlight by Prof. Cheng-Wei Qiu: https://www.sciengine.com/SCPMA/doi/10.1007/s11433-023-2195-4
Transferable neuronal mini-cultures to accelerate screening in primary and induced pluripotent stem cell-derived neurons
Creators: name: Wang, Yuli
name: Mabb, Angela M.
name: Allbritton, Nancy L.
name: Niedringhaus, Mark
name: Dumitru, Raluca
name: Taylor, Anne Marion
name: Philpot, Benjamin D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The effort and cost of obtaining neurons for large-scale screens has limited drug discovery in neuroscience. To overcome these obstacles, we fabricated arrays of releasable polystyrene micro-rafts to generate thousands of uniform, mobile neuron mini-cultures. These mini-cultures sustain synaptically-active neurons which can be easily transferred, thus increasing screening throughput by >30-fold. Compared to conventional methods, micro-raft cultures exhibited significantly improved neuronal viability and sample-to-sample consistency. We validated the screening utility of these mini-cultures for both mouse neurons and human induced pluripotent stem cell-derived neurons by successfully detecting disease-related defects in synaptic transmission and identifying candidate small molecule therapeutics. This affordable high-throughput approach has the potential to transform drug discovery in neuroscience.
Additional file 9 of Functional changes in the oral microbiome after use of fluoride and arginine containing dentifrices: a metagenomic and metatranscriptomic study
Creators: name: Carda-Diéguez, Miguel
name: Moazzez, Rebecca
name: Mira, Alex
Publisher: name: figshare
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics

description: Additional file 9: Additional Figure 8. Changes in bacterial communities’ gene content and activity after Fluoride treatment. Each dot represents a gene that was significantly under- or over-represented in the metagenomics (MTG) or metatranscriptomic (MTT) datasets after 3-month use of fluoride dentifrice. The abundance/expression level in the MTG/MTT datasets (expressed as the number of reads normalized per gene length per Mpb of sequencing coverage) and the fold change (RLM before/RLM after) are shown for each gene. Dots corresponding to genes over-represented in baseline are colored in blue and those over-represented after Fluoride treatment are depicted in orange. Genes differentially represented in caries-active sites (CA) and Caries-free individuals (CF) are shown at the top and lower panels, respectively.
The unusual magnetism of nanoparticle LaCoO3
Creators: name: Durand, A. M.
name: Belanger, D. P.
name: Hamil, T. J.
name: Ye, F.
name: Chi, S.
name: Fernandez-Baca, J. A.
name: Booth, C. H.
name: Abdollahian, Y.
name: Bhat, M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Bulk and nanoparticle powders of LaCoO3 (LCO) were synthesized, and their magnetic and structural properties were studied using SQUID magnetometry and neutron diffraction. The bulk and large nanoparticles exhibit weak ferromagnetism (FM) below T ~ 85K and a crossover from strong to weak antiferromagnetic (AFM) correlations near a transition expressed in the lattice parameters, To ~ 40K. This crossover does not occur in the smallest nanoparticles; instead, the magnetic behavior is predominantly ferromagnetic. The amount of FM in the nanoparticles depends on the amount of Co3O4 impurity phase, which induces tensile strain on the LCO lattice. A core-interface model is introduced, with the core region exhibiting the AFM crossover and with FM in the interface region near surfaces and impurity phases.
description: 7 pages, 4 figures
Additional file 1 of Prevalence of HIV testing and associated factors among young adolescents in Eswatini: a secondary data analysis
Creators: name: Jung, Mi Sook
name: Dlamini, Nondumiso Satiso
name: Cui, Xirong
name: Cha, Kyeongin
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Statistics
subject: FOS: Mathematics
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: Additional file 1. Questionnaire.
Cepheid Variables in the Flared Outer Disk of our Galaxy
Creators: name: Feast, Michael W.
name: Menzies, John W.
name: Matsunaga, Noriyuki
name: Whitelock, Patricia A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Flaring and warping of the disk of the Milky Way have been inferred from observations of atomic hydrogen, but stars associated with flaring have not hitherto been reported. In the area beyond the Galactic centre the stars are largely hidden from view by dust, and the kinematic distances of the gas cannot be estimated. Thirty-two possible Cepheid stars (young pulsating variable stars) in the direction of the Galactic bulge were recently identified. With their well-calibrated period-luminosity relationships, Cepheid stars are useful distance indicators. When observations of these stars are made in two colours, so that their distance and reddening can be determined simultaneously, the problems of dust obscuration are minimized. Here we report that five of the candidates are classical Cepheid stars. These five stars are distributed from approximately one to two kiloparsecs above and below the plane of the Galaxy, at radial distances of about 13 to 22 kiloparsecs from the centre. The presence of these relatively young (less than 130 million years old) stars so far from the Galactic plane is puzzling, unless they are in the flared outer disk. If so, they may be associated with the outer molecular arm.
description: 12 pages, 1 figure. This is almost identical to the Letter to Nature
СОВЕРШЕНСТВОВАНИЕ ПРАВОВОГО МЕХАНИЗМА, ГАРАНТИРУЮЩЕГО ПОЛНОЕ ФИНАНСОВОЕ ВОЗМЕЩЕНИЕ ВРЕДА, ПРИЧИНЕННОГО ОКРУЖАЮЩЕЙ СРЕДЕ В РЕЗУЛЬТАТЕ РАЗЛИВОВ НЕФТИ И НЕФТЕПРОДУКТОВ, В СВЕТЕ АВАРИИ, ПРОИЗОШЕДШЕЙ В 2020 ГОДУ В НОРИЛЬСКЕ
Creators: name: Захарова М.А.
Publisher: name: Образование и право
Year: 2022
Subjects: разлив нефти и нефтепродуктов
возмещение вреда
причиненного окружающей среде
авария
предупреждение и ликвидация разливов.

description: Авария на территории ТЭЦ-3 в Норильске, произошедшая в конце мая 2020 года, обратила внимание государства на необходимость изменения экологического законодательства. Так, Федеральным законом от 13.07.2020 № 207-ФЗ были внесены изменения в статью 46 ФЗ от 10.01.2002 № 7-ФЗ «Об охране окружающей среды», предусматривающие увеличение объема обязанностей и уровня финансовых обязательств эксплуатирующих организаций в соответствующей сфере. Целью работы является анализ внесенных изменений в Закон об охране окружающей среды. Делается вывод о том, что при всех положительных чертах законодательных нововведений в существующих реалиях требуется комплексный подход, включающий работу не столько с последствиями причинения вреда окружающей среде, сколько нацеленный в большей степени на его предотвращение.
Discovery of a correlation between the frequency of the mHz quasi-periodic oscillations and the neutron-star temperature in the low-mass X-ray binary 4U 1636-53
Creators: name: Lyu, Ming
name: Mendez, Mariano
name: Altamirano, Diego
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We detected millihertz quasi-periodic oscillations (QPOs) in an XMM-Newton observation of the neutron-star low-mass X-ray binary 4U 1636-53. These QPOs have been interpreted as marginally-stable burning on the neutron-star surface. At the beginning of the observation the QPO was at around 8 mHz, together with a possible second harmonic. About 12 ks into the observation a type I X-ray burst occurred and the QPO disappeared; the QPO reappeared ~25 ks after the burst and it was present until the end of the observation. We divided the observation into four segments to study the evolution of the spectral properties of the source during intervals with and without mHz QPO. We find that the temperature of the neutron-star surface increases from the QPO segment to the non-QPO segment, and vice versa. We also find a strong correlation between the frequency of the mHz QPO and the temperature of a black-body component in the energy spectrum representing the temperature of neutron-star surface. Our results are consistent with previous results that the frequency of the mHz QPO depends on the variation of the heat flux from the neutron star crust, and therefore supports the suggestion that the observed QPO frequency drifts could be caused by the cooling of deeper layers.
description: Accepted for publication in the MNRAS
Analisis Keterbatasan Guru Dalam Era Digital: Implikasi Bagi Kualitas Pendidikan
Creators: name: Ilham Ilahi, Rahmat Fajar, Sarinah Septeria Anggraini, Vebby Sandrina Hasandi, Afriyanti Elsyah Br Sirait, Amirah Faza, Anggraini Anggraini, Atha Muhammad, Eva Dwi Kartika, Widya Monica Lastri, Yandy Anugraha Saputra
Publisher: name: Zenodo
Year: 2024

description: Penelitian ini bertujuan untuk menganalisis Transformasi Peran Guru di Era Digital. Metode dalam penelitian ini adalah metode penelitian kualitatifdengan pendekatan naratif. Data wawancara ditranskripsi dan ditelaah dengan menggunakan analisis konten tematik. Studi ini melaporkan tiga tema data penting yang mencakup kemampuan adaptasi guru dengan era digital, tantangan yang dihadapi guru pada pembelajaran di era digital, peluang yang dihadapi guru pada pembelajaran di era digital dan strategi guru dalam menghadapi pembelajaran di era digital. Dengan begitu peneliti menyelidiki bagaimana guru dapat mengatasi tantangan ini dan memanfaatkan peluang tersebut untuk meningkatkan kualitas pendidikan di era digital. Dengan menggabungkan pendekatan inovatif dalam pengajaran dan investasi dalam pengembangan profesional guru, transformasi peran guru di era digital dapat menjadi kendaraan untuk menciptakan pengalaman pembelajaran yang lebih efektif dan inklusif.
TRPV4 channel activation selectively inhibits tumor endothelial cell proliferation
Creators: name: Gary Meszaros, J.
name: Paruchuri, Sailaja
name: Thodeti, Charles K.
name: Thoppil, Roslin J.
name: Cappelli, Holly C.
name: Kondeti, Vinay
name: Dudley, Andrew C.
name: Adapala, Ravi K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Endothelial cell proliferation is a critical event during angiogenesis, regulated by both soluble factors and mechanical forces. Although the proliferation of tumor cells is studied extensively, little is known about the proliferation of tumor endothelial cells (TEC) and its contribution to tumor angiogenesis. We have recently shown that reduced expression of the mechanosensitive ion channel TRPV4 in TEC causes aberrant mechanosensitivity that result in abnormal angiogenesis. Here, we show that TEC display increased proliferation compared to normal endothelial cells (NEC). Further, we found that TEC exhibit high basal ERK1/2 phosphorylation and increased expression of proliferative genes important in the G1/S phase of the cell cycle. Importantly, pharmacological activation of TRPV4, with a small molecular activator GSK1016790A (GSK), significantly inhibited TEC proliferation, but had no effect on the proliferation of NEC or the tumor cells (epithelial) themselves. This reduction in TEC proliferation by TRPV4 activation was correlated with a decrease in high basal ERK1/2 phosphorylation. Finally, using a syngeneic tumor model revealed that TRPV4 activation, with GSK, significantly reduced endothelial cell proliferation in vivo. Our findings suggest that TRPV4 channels regulate tumor angiogenesis by selectively inhibiting tumor endothelial cell proliferation.
СОТРУДНИЧЕСТВО РОССИИ С КИТАЕМ И ЕГО ЗНАЧЕНИЕ ДЛЯ РОСТА И РАЗВИТИЯ ЭКОНОМИКИ РОССИИ
Creators: name: Родыгина Н.Ю.
name: Обуховская Л.А.
name: Еремеева Е.И.
name: Мусихин В.И.
Publisher: name: Образование и право
Year: 2022
Subjects: международная торговля
международные отношения
отношения России и Китая
развитие отношений
российско-китайское сотрудничество
история сотрудничества
внешнеполитические отношения.

description: В статье рассмотрена эволюция торгово-экономических отношений России и Китая, проведен ретроспективный анализ. На сегодняшний день происходит значительный рост товарооборота между двумя странами, усиливается переплетение хозяйственных комплексов, возрастает число целевых контактов. Отмечается, что у инвесторов из КНР наблюдается заинтересованность в российском рынке, видено увеличение важных инвестиции в отечественную экономику, созданы, а также осуществляют совместную проектную работу многие компании России и Китая в таких сферах, как, например, машиностроение, строительство, медицина, фармацевтическая промышленность, энергетика, нефтегазовый сектор, атомная энергетика. В настоящий период связь Китая и России во многих сферах приобрела новые качественные характеристики, что приобретает важное стратегическое значение для экономики РФ в текущих напряженных геополитических условиях.
Gravitational waves from rapidly rotating neutron stars
Creators: name: Haskell, Brynmor
name: Andersson, Nils
name: D`Angelo, Caroline
name: Degenaar, Nathalie
name: Glampedakis, Kostas
name: Ho, Wynn C. G.
name: Lasky, Paul D.
name: Melatos, Andrew
name: Oppenoorth, Manuel
name: Patruno, Alessandro
name: Priymak, Maxim
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Rapidly rotating neutron stars in Low Mass X-ray Binaries have been proposed as an interesting source of gravitational waves. In this chapter we present estimates of the gravitational wave emission for various scenarios, given the (electromagnetically) observed characteristics of these systems. First of all we focus on the r-mode instability and show that a 'minimal' neutron star model (which does not incorporate exotica in the core, dynamically important magnetic fields or superfluid degrees of freedom), is not consistent with observations. We then present estimates of both thermally induced and magnetically sustained mountains in the crust. In general magnetic mountains are likely to be detectable only if the buried magnetic field of the star is of the order of $B\approx 10^{12}$ G. In the thermal mountain case we find that gravitational wave emission from persistent systems may be detected by ground based interferometers. Finally we re-asses the idea that gravitational wave emission may be balancing the accretion torque in these systems, and show that in most cases the disc/magnetosphere interaction can account for the observed spin periods.
description: To appear in 'Gravitational Waves Astrophysics: 3rd Session of the Sant Cugat Forum on Astrophysics, 2014', Editor: Carlos F. Sopuerta
Universal behavior of hydrogels confined to narrow capillaries
Creators: name: Li, Yang
name: Kumacheva, Eugenia
name: Ramachandran, Arun
name: Sarıyer, Ozan S.
name: Rubinstein, Michael
name: Panyukov, Sergey
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Flow of soft matter objects through one-dimensional environments is important in industrial, biological and biomedical systems. Establishing the underlying principles of the behavior of soft matter in confinement can shed light on its performance in many man-made and biological systems. Here, we report an experimental and theoretical study of translocation of micrometer-size hydrogels (microgels) through microfluidic channels with a diameter smaller than an unperturbed microgel size. For microgels with different dimensions and mechanical properties, under a range of applied pressures, we established the universal principles of microgel entrance and passage through microchannels with different geometries, as well as the reduction in microgel volume in confinement. We also show a non-monotonic change in the flow rate of liquid through the constrained microgel, governed by its progressive confinement. The experimental results were in agreement with the theory developed for non-linear biaxial deformation of unentangled polymer gels. Our work has implications for a broad range of phenomena, including occlusion of blood vessels by thrombi and needle-assisted hydrogel injection in tissue engineering.
Political participation and civic engagement of Muslim young adults in the United States
Creators: name: Abbasi, Mohammad I.
Publisher: name: No Publisher Supplied
Year: 2024

description: This dissertation addresses political and civic engagement among young Muslims in the United States (US). In this dissertation, I uncover the enigmatic role that young Muslims in the US play in defending their communities in the wake of 9/11. Understanding how these young adults express their civic and political voice is an important contribution to the study of public affairs, with specific relevance to the intricate landscape of the political and civic participation of minoritized individuals in this country. Drawing upon a recently collected dataset, this research seeks to elucidate the diverse avenues through which young Muslims in the US actively participate in democratic processes. In this dissertation, I examine voting behavior, political and civic engagement, and dual activism. The selection of these modes is underpinned by their alignment with well-established theories of political and civic participation, such as rational choice theory, social capital theory, resource theory, political socialization theory, mobilization theory and the civic voluntarism model. This research unveils clear, unambiguous evidence of lower participation rates among American Muslim young adults in comparison with their older cohorts. Furthermore, the research reveals significant variations in participation shaped by gender, ethnicity, religiosity, education, organizational associations, and political orientation. These findings provide valuable insights for community leaders, and public administrators seeking to effectively engage with this strategically important demographic, ultimately enhancing young adult Muslims’ contributions to the broader civic and political discourse within the nation.
Additional file 1 of Development and validation of a pre- and intra-operative scoring system that distinguishes between non-advanced and advanced axillary lymph node metastasis in breast cancer with positive sentinel lymph nodes: a retrospective study
Creators: name: Murata, Takeshi
name: Watase, Chikashi
name: Shiino, Sho
name: Kurita, Arisa
name: Ogawa, Ayumi
name: Jimbo, Kenjiro
name: Iwamoto, Eriko
name: Yoshida, Masayuki
name: Takayama, Shin
name: Suto, Akihiko
Publisher: name: figshare
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Hematology

description: Additional file 1: Figure S1. Comparison of ROC curves of the scoring system between the training (A) and validation (B) cohorts and the analysis of independent factors to differentiate between non-advanced and advanced ALNM in both these cohorts. Figure S2. ROC curves of the scoring system compared between the training (A) and validation cohorts (B) and presentation of independent factors for differentiating between non-advanced and advanced ALNM in the two cohorts and calibration plots of the scoring system for the training cohort (C) and the validation cohort (D) in patients with one or two metastatic SLNs.
The density structure of the L1157 molecular outflow
Creators: name: Gómez-Ruiz, A. I.
name: Codella, C.
name: Lefloch, B.
name: Benedettini, M.
name: Busquet, G.
name: Ceccarelli, C.
name: Nisini, B.
name: Podio, L.
name: Viti, S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present a multiline CS survey towards the brightest bow-shock B1 in the prototypical chemically active protostellar outflow L1157. We made use of (sub-)mm data obtained in the framework of the Chemical HErschel Surveys of Star forming regions (CHESS) and Astrochemical Surveys at IRAM (ASAI) key science programs. We detected $^{12}$C$^{32}$S, $^{12}$C$^{34}$S, $^{13}$C$^{32}$S, and $^{12}$C$^{33}$S emissions, for a total of 18 transitions, with $E_{\rm u}$ up to $\sim$ 180 K. The unprecedented sensitivity of the survey allows us to carefully analyse the line profiles, revealing high-velocity emission, up to 20 km s$^{-1}$ with respect to the systemic. The profiles can be well fitted by a combination of two exponential laws that are remarkably similar to what previously found using CO. These components have been related to the cavity walls produced by the $\sim$ 2000 yr B1 shock and the older ($\sim$ 4000 yr) B2 shock, respectively. The combination of low- and high-excitation CS emission was used to properly sample the different physical components expected in a shocked region. Our CS observations show that this molecule is highlighting the dense, $n_{\rm H_2}$ = 1--5 $\times$ 10$^{5}$ cm$^{-3}$, cavity walls produced by the episodic outflow in L1157. In addition, the highest excitation (E$_u$ $\geq$ 130 K) CS lines provide us with the signature of denser (1--5 $\times$ 10$^{6}$ cm$^{-3}$) gas, associated with a molecular reformation zone of a dissociative J-type shock, which is expected to arise where the precessing jet impacting the molecular cavities. The CS fractional abundance increases up to $\sim$ 10$^{-7}$ in all the kinematical components. This value is consistent with what previously found for prototypical protostars and it is in agreement with the prediction of the abundances obtained via the chemical code Astrochem.
description: 11 pages, 10 figures, accepted for publication in Monthly Notices of the Royal Astronomical Society (MNRAS)
Additional file 1 of Spanish version of the Pediatric Anesthesia Emergence Delirium scale: translation and cross-cultural adaptation
Creators: name: Epulef, Valeria
name: Muñoz, Sergio
name: Alarcón, Ana María
name: Vial, Manuel
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Science Policy

description: Additional file 1.
ТЕАТР – ОБЪЕКТ КУЛЬТУРНОЙ ПОЛИТИКИ ГОСУДАРСТВА
Creators: name: Гущин В.В.
name: Кучер В.А.
Publisher: name: Образование и право
Year: 2022
Subjects: культурная политика
театр
проектная деятельность
финансирование
бюджетные средства
контракт.

description: Положениями действующего российского законодательства определено место театра культурной политике государства. Дается определение культурной политики, театра. Рассматриваются вопросы финансирования театра в результате реализации проекта.Проект рассматривается как одна из форм творческо-производственной деятельности в театре, котораяфинансируется за счет бюджетных средств на конкурсной основе.
УГОЛОВНО-ПРАВОВАЯ ПОЛИТИКА В СФЕРЕ ПРИМЕНЕНИЯ СМЕРТНОЙ КАЗНИ КАК ВЫСШЕЙ МЕРЫ НАКАЗАНИЯ
Creators: name: Каражелясков Б.А.
name: Карпушева Л.Н.
name: Юнусов М.Ф.
Publisher: name: Образование и право
Year: 2022
Subjects: уголовно-правовая политика
высшая мера наказания
смертная казнь.

description: Отсутствие единой уголовно-правовой политики дает основание для возникновения ряда дискуссионных вопросов, так в частности к ним относится вопрос применения смертной казни как высшей меры наказания. Помимо этого, уголовно-правовая политика направлена на снижение уровня преступности, так как определяет стратегию и тактику противодействия преступности. Применение смертной казни в России было прекращено с вступлением в Совет Европы. Однако несмотря на то, что Россия покинула Совет Европы, Конституционный Суд Российской Федерации считает отсутствие оснований для отхождения от придерживающегося мнения несколько десятилетий, не применения смертной казни. Конституционный Суд Российской Федерации считает, что в России нет предпосылок для применения смертной казни. Однако, во-первых, смертная казнь как вид уголовного наказания единственный вид, который имеет конституционно-правовое закрепление, во-вторых, по результатам многочисленных опросов, 60-70 % населения считают возможным применение смертной казни. В сложившихся условиях, необходимо определить направления уголовно-правовой политики в отношении применения смертной казни в России.
Towards Better Generalization with Flexible Representation of Multi-Module Graph Neural Networks
Creators: name: Lee, Hyungeun
name: Yoon, Kijung
Publisher: name: arXiv
Year: 2022
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Graph neural networks (GNNs) have become compelling models designed to perform learning and inference on graph-structured data. However, little work has been done to understand the fundamental limitations of GNNs for scaling to larger graphs and generalizing to out-of-distribution (OOD) inputs. In this paper, we use a random graph generator to systematically investigate how the graph size and structural properties affect the predictive performance of GNNs. We present specific evidence that the average node degree is a key feature in determining whether GNNs can generalize to unseen graphs, and that the use of multiple node update functions can improve the generalization performance of GNNs when dealing with graphs of multimodal degree distributions. Accordingly, we propose a multi-module GNN framework that allows the network to adapt flexibly to new graphs by generalizing a single canonical nonlinear transformation over aggregated inputs. Our results show that the multi-module GNNs improve the OOD generalization on a variety of inference tasks in the direction of diverse structural features.
Examining the Relationship Between Word Reading Efficiency and Oral Reading Rate in Predicting Comprehension Among Different Types of Readers
Creators: name: Bruce, Kelly
name: Cutting, Laurie E.
name: Goldberg, Lindsay
name: Eason, Sarah H.
name: Sabatini, John
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: To further explore contextual reading rate, an important aspect of reading fluency, we examined the relationship between word reading efficiency (WRE) and contextual oral reading rate (ORR), the degree to which they overlap across different comprehension measures, whether oral language (semantics and syntax) predicts ORR beyond contributions of word-level skills, and whether the WRE–ORR relationship varies based on different reader profiles. Assessing reading and language of average readers, poor decoders, and poor comprehenders, ages 10 to 14, ORR was the strongest predictor of comprehension across various formats; WRE contributed no unique variance after taking ORR into account. Findings indicated that semantics, not syntax, contributed to ORR. Poor comprehenders performed below average on measures of ORR, despite average WRE, expanding previous findings suggesting specific weaknesses in ORR for this group. Together, findings suggest that ORR draws upon skills beyond those captured by WRE and suggests a role for oral language (semantics) in ORR.
Composition and content of photosynthetic pigments in plankton of the Volga River reservoirs (2015-2016)
Creators: name: Mineeva, N.M.
Publisher: name: Труды Института биологии внутренних вод РАН
Year: 2018
Subjects: ФОТОСИНТЕТИЧЕСКИЕ ПИГМЕНТЫ
PHOTOSYNTHETIC PIGMENTS
ВОДОХРАНИЛИЩА ВОЛГИ
VOLGA RIVER RESERVOIRS
ТРОФИЧЕСКИЙ СТАТУС
TROPHIC STATE

description: Data on the composition and content of photosynthetic pigments in plankton of the Volga River reservoirs in the summer period of 2015 and 2016 are under consideration. Chlorophyll content determined by standard spectrophotometric and fluorescent methods correlate with each other ( R 2 = 0.78). The average concentration of chlorophylls (Chl a + b + c ) in June in the Kuibyshev, Saratov, and Volgograd reservoirs was 4.0-5.5 μg/L, in Gorky and Cheboksary reservoirs 10.0-14.7 μg/L, in unregulated part of the Lower Volga 22.5 μg/L. Chl a + b + c content in August was 20.5-34.4 μg/L in five upper reservoirs of the cascade, 6.3 and 6.7 μg/L in Kuibyshev and Saratov reservoirs (2015), 10.9 μg/L in Gorky reservoir, and 16.3-26.4 μg/L in others (2016). Chl a prevails in the fund of the green pigments (71-85% in June, 67-93% in August), the share of Chl c is 6-29%, the share of Chl b is 1-9%. Pheopigments content is equal to 26-78%, the plant carotenoids and chlorophyll content is commensurable. The contribution of blue-green algae (an average of 36-56% in June and 60-90% in August) and diatoms (40-60% and 9-40%) to the total amount of Chl a corresponds to the taxonomic composition of the Volga phytoplankton. The trophic status of the reservoirs of the Middle Volga in the early summer is characterized as mesotrophic and only Cheboksary reservoir is moderate eutrophic. At the height of the summer, Ivankovo, Uglich, and Cheboksary reservoirs are considered eutrophic category. The status of the Rybinsk reservoir during the study period varies from moderate eutrophic to eutrophic, Gorky reservoir from mesotrophic to eutrophic, Kuibyshev reservoir from mesotrophic to moderately eutrophic. Reservoirs of the Lower Volga are characterized as mesotrophic.
A framework for benchmarking clustering algorithms
Creators: name: Gagolewski, Marek
Publisher: name: arXiv
Year: 2022
Subjects: subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: The evaluation of clustering algorithms can involve running them on a variety of benchmark problems, and comparing their outputs to the reference, ground-truth groupings provided by experts. Unfortunately, many research papers and graduate theses consider only a small number of datasets. Also, the fact that there can be many equally valid ways to cluster a given problem set is rarely taken into account. In order to overcome these limitations, we have developed a framework whose aim is to introduce a consistent methodology for testing clustering algorithms. Furthermore, we have aggregated, polished, and standardised many clustering benchmark dataset collections referred to across the machine learning and data mining literature, and included new datasets of different dimensionalities, sizes, and cluster types. An interactive datasets explorer, the documentation of the Python API, a description of the ways to interact with the framework from other programming languages such as R or MATLAB, and other details are all provided at .
description: This preprint includes some minor corrections