cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The power of argument
Creators: name: Runhaar, Hens
name: Runhaar, Piety
name: Bouwmans, Machiel
name: Vink, Simon
name: Buijs, Arjen
name: Kleijn, David
Publisher: name: Figshare
Year: 2019
Subjects: subject: Medicine
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Ecology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Agrobiodiversity has been decreasing substantially in Europe. Social scientific research in this area has paid limited attention to how citizens value agrobiodiversity and its decline, and how these valuations can be influenced. We explore the influence of different arguments for enhancing agro-biodiversity, delivered via short movies, on attitudes and behaviour of students, environmental professionals and people interested in nature conservation in the Netherlands. We conclude that information provision does not influence attitudes. However, it does influence values assigned to agrobiodiversity, but not always in the ways we hypothesized. Information about the intrinsic value of agrobiodiversity has the most effects on values assigned to agrobiodiversity. Among students, women and people with a low emotional attachment with agricultural landscapes (‘place identity’ and ‘place dependence’), emphasizing the instrumental value of agrobiodiversity has a counter-intuitive effect. It does not influence the importance of this value but instead reinforces the intrinsic value they assign to agrobiodiversity. The latter finding is at odds with the instrumental biodiversity discourse in science and policy, which, under headings such as ecosystem services and natural capital, aims to mobilize support for nature conservation by emphasizing its instrumental, functional and economic values. Emphasizing the intrinsic value of agrobiodiversity seems more effective.
Temperatures and Metallicities of M Dwarfs in the APOGEE Survey
Creators: name: Mann, A.W.
name: Burgasser, A.
name: Birky, J.
name: Hogg, D.W.
Publisher: name: Institute of Physics Publishing
Year: 2020

description: M dwarfs have enormous potential for our understanding of structure and formation on both Galactic and exoplanetary scales through their properties and compositions. However, current atmosphere models have limited ability to reproduce spectral features in stars at the coolest temperatures (T eff < 4200 K) and to fully exploit the information content of current and upcoming large-scale spectroscopic surveys. Here we present a catalog of spectroscopic temperatures, metallicities, and spectral types for 5875 M dwarfs in the Apache Point Observatory Galactic Evolution Experiment (APOGEE) and Gaia-DR2 surveys using The Cannon: A flexible, data-driven spectral-modeling and parameter-inference framework demonstrated to estimate stellar-parameter labels, and detailed abundances) to high precision. Using a training sample of 87 M dwarfs with optically derived labels spanning calibrated with bolometric temperatures, and dex calibrated with FGK binary metallicities, we train a two-parameter model with predictive accuracy (in cross-validation) to 77 K and 0.09 dex respectively. We also train a one-dimensional spectral classification model using 51 M dwarfs with Sloan Digital Sky Survey optical spectral types ranging from M0 to M6, to predictive accuracy of 0.7 types. We find Cannon temperatures to be in agreement to within 60 K compared to a subsample of 1702 sources with color-derived temperatures, and Cannon metallicities to be in agreement to within 0.08 dex metallicity compared to a subsample of 15 FGK+M or M+M binaries. Finally, our comparison between Cannon and APOGEE pipeline (ASPCAP DR14) labels finds that ASPCAP is systematically biased toward reporting higher temperatures and lower metallicities for M dwarfs.
Application of Independent Component Analysis Techniques in Speckle Noise Reduction of Retinal OCT Images
Creators: name: Baghaie, Ahmadreza
name: D'souza, Roshan M.
name: Yu, Zeyun
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Optical Coherence Tomography (OCT) is an emerging technique in the field of biomedical imaging, with applications in ophthalmology, dermatology, coronary imaging etc. OCT images usually suffer from a granular pattern, called speckle noise, which restricts the process of interpretation. Therefore the need for speckle noise reduction techniques is of high importance. To the best of our knowledge, use of Independent Component Analysis (ICA) techniques has never been explored for speckle reduction of OCT images. Here, a comparative study of several ICA techniques (InfoMax, JADE, FastICA and SOBI) is provided for noise reduction of retinal OCT images. Having multiple B-scans of the same location, the eye movements are compensated using a rigid registration technique. Then, different ICA techniques are applied to the aggregated set of B-scans for extracting the noise-free image. Signal-to-Noise-Ratio (SNR), Contrast-to-Noise-Ratio (CNR) and Equivalent-Number-of-Looks (ENL), as well as analysis on the computational complexity of the methods, are considered as metrics for comparison. The results show that use of ICA can be beneficial, especially in case of having fewer number of B-scans.
In vitro activities of and mechanisms of resistance to antifol antimalarial drugs.
Creators: name: Bowdre, J H
name: Weatherly, N F
name: Desjardins, R E
name: Milhous, W K
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1985

description: Certain drugs that interfere with folate metabolism (sulfones, sulfonamides, and inhibitors of dihydrofolate reductase) play an important role in the chemotherapy and prophylaxis of malaria. The activities and mechanisms of action of these drugs are regarded as similar in most respects to their activities against procaryotic microorganisms. Believed incapable of utilizing intact exogenous folates, plasmodia have been regarded as dependent on de novo synthesis of required folate cofactors. The present investigation, conducted in pursuit of a method for testing the in vitro susceptibility of Plasmodium falciparum to antifol antimalarial drugs, produced evidence that earlier assumptions about the folate metabolism of this organism are not correct. Three of four isolates of P. falciparum were successfully maintained in a culture medium depleted of folic acid and p-aminobenzoic acid. The antimalarial activities of sulfonamides and dihydrofolate reductase inhibitors were, furthermore, variably antagonized by the presence of folic acid and p-aminobenzoic acid in the culture medium. Optimum conditions for assessment of antifol antimalarial activity in vitro therefore require precise control of these factors in the culture medium. Our results suggest that resistance to antifol antimalarial drugs involves a complex of factors related to both the de novo synthesis of active folate cofactors and the ability to utilize exogenous intact folates in various forms.
Interaction of Epstein-Barr virus DNA polymerase and 5'-triphosphates of several antiviral nucleoside analogs.
Creators: name: Cheng, Y C
name: Chiou, J F
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1985

description: The 5'-triphosphates of 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-methyluracil, 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine, 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-methylcytosine, 9-[(2-hydroxyethoxy)methyl]guanine, and 9-(1,3-dihydroxy-2-propoxymethyl)guanine had lower Ki values for Epstein-Barr virus DNA polymerase than has been reported elsewhere for host DNA polymerase. Inhibition of DNA elongation by these analogs ranged from moderate to strong, suggesting that preferential incorporation of these analogs into DNA by virus DNA polymerase may contribute to antiviral selectivity.
Mutually exclusive inhibition of herpesvirus DNA polymerase by aphidicolin, phosphonoformate, and acyclic nucleoside triphosphates.
Creators: name: Frank, K B
name: Cheng, Y C
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1985

description: Dual inhibitor studies were performed to examine the interaction of aphidicolin, phosphonoformate, 9-(2-hydroxyethoxymethyl)guanine triphosphate, and 9-(1,3-dihydroxy-2-propoxymethyl)guanine triphosphate with herpes simplex virus DNA polymerase. Kinetic data indicated that inhibition by one agent prevents simultaneous inhibition by a second agent, producing a mutually exclusive inhibition pattern. This suggested that binding sites on the DNA polymerase molecule for these compounds are kinetically overlapping. These findings should be taken into consideration for the design of future antiviral compounds and combination chemotherapy protocols.
Fully developed isotropic turbulence: symmetries and exact identities
Creators: name: Canet, Léonie
name: Delamotte, Bertrand
name: Wschebor, Nicolás
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: High Energy Physics - Theory (hep-th)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: We consider the regime of fully developed isotropic and homogeneous turbulence of the Navier-Stokes equation with a stochastic forcing. We present two gauge symmetries of the corresponding Navier-Stokes field theory, and derive the associated general Ward identities. Furthermore, by introducing a local source bilinear in the velocity field, we show that these symmetries entail an infinite set of exact and local relations between correlation functions. They include in particular the Kármán-Howarth relation and another exact relation for a pressure-velocity correlation function recently derived in Ref. [G. Falkovich, I. Fouxon, Y. Oz,J. Fluid Mech. 644, 465 (2010)], that we further generalize.
description: 8 pages, published version
Additional file 1 of Nutrient dynamics in coral symbiosis depend on both the relative and absolute abundance of Symbiodiniaceae species
Creators: name: McIlroy, Shelby E.
name: terHorst, Casey P.
name: Teece, Mark
name: Coffroth, Mary Alice
Publisher: name: figshare
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Additional file 1: Table S1. Nutrient and isotopic compositions of artificial seawater media used for each stage of the experiment. Concentrations were based on Tanaka et al. (2006). All compounds were manufactured and purchased from Sigma-Aldrich ® (St. Louis, MO, USA). Fig. S1. Isotope baseline and dark controls. A set of recruits was tested to provide a baseline isotope value and to confirm that symbionts were the primer drivers of inorganic carbon and nitrogen into the symbiosis. Baseline recruits were sampled prior to the start of the experiment, Dark Enriched samples were exposed to isotopically enriched enriched nutriens but kept in the dark to inhibit photosynthesis; Enriched samples show the cumulative data from the final experiment. Fig. S2. The significant interaction effect of symbiont ratio and symbiont density on atom percent 13C values of symbiont tissues was examined by plotting the marginal effect of symbiont ratio (S.m.:B.m.) as moderated by symbiont density (cells/recruit). Green bar indicates the range of symbiont densities in which there is a significant positive effect of symbiont ratio on AP13Csym. Gray area shows the 95% CI. Fig. S3. The significant interaction effect of symbiont ratio and symbiont density on atom percent 15N values of host tissues was examined by plotting the marginal effect of symbiont density as moderated by symbiont ratio (S.m.:B.m.). Red bar indicates the range of symbiont ratios in which there is a significant negative effect of symbiont density on AP15Nhost. Gray area shows 95% CI. Fig. S4. The significant interaction effect of symbiont ratio and symbiont density on atom percent 15N values of symbiont tissues was examined by plotting the marginal effect of symbiont ratio (S.m.:B.m.) as moderated by symbiont density (cells/recruit). Red bar indicates the range of symbiont densities in which there is a significant negative effect of symbiont ratio on AP15Nsym. Gray area shows the 95% CI. Fig. S5. The significant interaction effect of symbiont ratio and symbiont density on atom percent 15N values of symbiont tissues was examined by plotting the marginal effect of symbiont density as moderated by symbiont ratio (S.m.:B.m.). Red bar indicates the range of symbiont ratios in which there is a significant negative effect of symbiont density on AP15Nsym. Gray area shows 95% CI. Fig. S6. The significant interaction effect of symbiont ratio and symbiont density on total assimilated nitrogen (mg/recruit) was examined by plotting the marginal effect of symbiont density as moderated by symbiont ratio (S.m.:B.m.). Red bar indicates the range of symbiont ratios in which there is a significant negative effect of symbiont density on total assimialted nitrogen. Gray area shows 95% CI.
Automated NNLL+NLO Resummation for Jet-Veto Cross Sections
Creators: name: Becher, Thomas
name: Frederix, Rikkert
name: Neubert, Matthias
name: Rothen, Lorena
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In electroweak-boson production processes with a jet veto, higher-order corrections are enhanced by logarithms of the veto scale over the invariant mass of the boson system. In this paper, we resum these Sudakov logarithms at next-to-next-to-leading logarithmic (NNLL) accuracy and match our predictions to next-to-leading order (NLO) fixed-order results. We perform the calculation in an automated way, for arbitrary electroweak final states and in the presence of kinematic cuts on the leptons produced in the decays of the electroweak bosons. The resummation is based on a factorization theorem for the cross sections into hard functions, which encode the virtual corrections to the boson production process, and beam functions, which describe the low-p_T emissions collinear to the beams. The one-loop hard functions for arbitrary processes are calculated using the MadGraph5_aMC@NLO framework, while the beam functions are process independent. We perform the resummation for a variety of processes, in particular for W+W- pair production followed by leptonic decays of the W bosons.
description: 26 pages, 9 figures. v2: journal version
title: Multispectral Registration, Undistortion and Tree Detection for Precision Agriculture
Creators: name: Ruiz, Alfonso López
name: Rodríguez, Juan Manuel Jurado
name: Anguita, Carlos Javier Ogayar
name: Higueruela, Francisco Ramón Feito
Publisher: name: The Eurographics Association
Year: 2019
Subjects: Image registration
Multispectral image
Distortion removal
Image segmentation

description: Multi-lens multispectral cameras allow us to record multispectral information for a whole area of terrain, even though we may only need the vegetation data. Based on the intensity of each multispectral image we can retrieve the contours of the trees that appear on the recorded terrain. However, multispectral cameras use a physically different lens for each range of wavelengths and misregistration effects could appear due to the different viewing positions. As these types of lenses are dedicated to capture larger areas of terrain, their focal distance is lower and because of this we get what is called a fisheye distortion. Therefore if we want to retrieve the shape of each tree and its multispectral data we need to process the channels so them all are representated as undistorted images under a same reference system.
description: Spanish Computer Graphics Conference (CEIG)
description: Short Papers
description: 85
description: 88
description: Alfonso López Ruiz, Juan Manuel Jurado Rodríguez, Carlos Javier Ogayar Anguita, and Francisco Ramón Feito Higueruela
description: Keywords: Image registration, Multispectral image, Distortion removal, Image segmentation
Matrix geometries and fuzzy spaces as finite spectral triples
Creators: name: Barrett, John W.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: Operator Algebras (math.OA)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: A class of real spectral triples that are similar in structure to a Riemannian manifold but have a finite-dimensional Hilbert space is defined and investigated, determining a general form for the Dirac operator. Examples include fuzzy spaces defined as real spectral triples. Fuzzy 2-spheres are investigated in detail, and it is shown that the fuzzy analogues correspond to two spinor fields on the commutative sphere. In some cases it is necessary to add a mass mixing matrix to the commutative Dirac operator to get a precise agreement for the eigenvalues.
description: 39 pages, final version
Limits on the Spin-Orbit Angle and Atmospheric Escape for the 22 Myr Old Planet AU Mic b
Creators: name: Vievard, S.
name: Serizawa, T.
name: Ishizuka, M.
name: Narita, N.
name: Harakawa, H.
name: Hirano, T.
name: Hodapp, K.
name: Omiya, M.
name: Nishikawa, J.
name: Kudo, T.
name: Kurokawa, T.
name: Krishnamurthy, V.
name: Tamura, M.
name: Plavchan, P.
name: Jacobson, S.
name: Kuzuhara, M.
name: Konishi, M.
name: Flewelling, H.
name: Mann, A.W.
name: Ueda, A.
name: Kotani, T.
name: Gaidos, E.
Publisher: name: Institute of Physics Publishing
Year: 2020

description: We obtained spectra of the pre-main-sequence star AU Microscopii during a transit of its Neptune-sized planet to investigate its orbit and atmosphere. We used the high-dispersion near-infrared spectrograph InfraRed Doppler (IRD) on the Subaru telescope to detect the Doppler "shadow"from the planet and constrain the projected stellar obliquity. Modeling of the observed planetary Doppler shadow suggests a spin-orbit alignment of the system (λ =- 4.7-6.4+6.8 deg), but additional observations are needed to confirm this finding. We use both the IRD data and spectra obtained with NIRSPEC on Keck II to search for absorption in the 1083 nm line of metastable triplet He i by the planet's atmosphere and place an upper limit for the equivalent width of 3.7 mÅ at 99% confidence. With this limit and a Parker wind model we constrain the escape rate from the atmosphere to < 0.15 - 0.45 M ⊕ Gyr-1, comparable to the rates predicted by an X-ray and ultraviolet energy-limited escape calculation and hydrodynamic models, but refinement of the planet mass is needed for rigorous tests.
Genetics of resistance in a non-beta-lactamase-producing gonococcus with relatively high-level penicillin resistance.
Creators: name: Faruki, H
name: Sparling, P F
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1986

description: A penicillin-resistant (Penr) non-penicillinase-producing Neisseria gonorrhoeae strain responsible for an outbreak affecting 199 persons in Durham, N.C., in 1983 was studied to determine the genetic basis of its unusually high-level (MIC, 2.0 micrograms/ml) Penr. Plasmid screening of the strain revealed no plasmids other than the 2.6-megadalton cryptic plasmid. Penr was found to be partially due to mutations genotypically and phenotypically similar to the previously characterized chromosomal loci penA, mtr, and penB. Resistance loci from the epidemic donor strain were transformed into susceptible recipients FA19 and F62 in a stepwise fashion; the combination of the three loci resulted in moderate levels of penicillin resistance (MIC, 0.5 micrograms/ml), but donor levels of resistance were not obtainable in either recipient, for uncertain reasons. Occurrence of an antibiotic-susceptible (env) mutation in a clinical isolate of the Penr epidemic strain also was documented.
Quantum Monte Carlo study of the indirect Pauli exclusion effect in Bose-Fermi mixtures
Creators: name: Bertaina, G.
name: Guidini, A.
name: Pieri, P.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We study the momentum distributions of a three-dimensional resonant Bose-Fermi mixture in the molecular limit at zero temperature. For concentration of the bosons with respect to the fermions less or equal to one, each boson is bound to a fermion and the system is composed of fermionic molecules plus excess fermions. Not only the bosonic condensate fraction goes to zero, signaling a quantum phase transition towards a normal phase, but a finite region of low momenta is depleted, depending on the concentration. This phenomenon is named indirect Pauli exclusion effect and is demonstrated via Fixed-Node Diffusion Monte Carlo simulations and T-matrix calculations.
description: 5 pages, 3 figures, published in EPJ ST volume entitled "Novel Quantum Phases and Mesoscopic Physics in Quantum Gases"
Microplate phosphocellulose binding assay for aminoglycoside-modifying enzymes.
Creators: name: Cooksey, R C
name: Thornsberry, C
name: Metchock, B G
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1986

description: We modified the phosphocellulose binding assay for aminoglycoside-modifying enzymes (AMEs) by use of microdilution plates and a multichannel micropipette. Batteries of aminoglycoside substrates for screening organisms for the presence of AMEs as well as for subclassifying enzymes were prepared and stored in microdilution plates. When tested in parallel with the conventional tube reaction assay, the microplate assay yielded comparable radioactive counts and therefore equally correct identifications of AMEs in 32 isolates representing nine bacterial species. Other modifications, such as multichannel dispensing of crude enzyme preparations and radioisotopic precursors, provided a more rapid, convenient, and less expensive means of examining large collections of organisms for AMEs.
A Well-aligned Orbit for the 45 Myr-old Transiting Neptune DS Tuc Ab
Creators: name: Jao, W.C.
name: Paredes, L.A.
name: Thompson, I.
name: Teske, J.K.
name: Huang, C.X.
name: Butler, R.P.
name: Wang, S.
name: Winn, J.N.
name: Latham, D.W.
name: Zhou, G.
name: Crane, J.D.
name: Shectman, S.A.
name: Rodriguez, J.E.
name: Henry, T.J.
name: Newton, E.R.
name: Rizzuto, A.C.
name: Hinojosa, R.
name: James, H.S.
name: Mann, A.W.
name: Quinn, S.N.
name: Vanderburg, A.M.
Publisher: name: Institute of Physics Publishing
Year: 2020

description: DS Tuc Ab is a Neptune-sized planet that orbits around a G star in the 45 Myr old Tucana-Horologium moving group. Here, we report the measurement of the sky-projected angle between the stellar spin axis and the planet's orbital axis, based on the observation of the Rossiter-McLaughlin effect during three separate planetary transits. The orbit appears to be well aligned with the equator of the host star, with a projected obliquity of. In addition to the distortions in the stellar absorption lines due to the transiting planet, we observed variations that we attribute to large starspots, with angular sizes of tens of degrees. The technique that we have developed for simultaneous modeling of starspots and the planet-induced distortions may be useful in other observations of planets around active stars.
Constraints on the pMSSM, AMSB model and on other models from the search for long-lived charged particles in proton-proton collisions at sqrt(s) = 8 TeV
Creators: name: CMS Collaboration
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Stringent limits are set on the long-lived lepton-like sector of the phenomenological minimal supersymmetric standard model (pMSSM) and the anomaly-mediated supersymmetry breaking (AMSB) model. The limits are derived from the results presented in a recent search for long-lived charged particles in proton-proton collisions, based on data collected by the CMS detector at a centre-of-mass energy of 8 TeV at the Large Hadron Collider. In the pMSSM parameter sub-space considered, 95.9% of the points predicting charginos with a lifetime of at least 10 ns are excluded. These constraints on the pMSSM are the first obtained at the LHC. Charginos with a lifetime greater than 100 ns and masses up to about 800 GeV in the AMSB model are also excluded. The method described can also be used to set constraints on other models.
description: Published by Eur. Phys. J. C; updated to published version
Additional file 1: of Multiwalled carbon nanotubes decorated with bismuth (III) oxide for electrochemical detection of an antipyretic and analgesic drug paracetamol in biological samples
Creators: name: Chipeture, Arthur
name: Apath, Daniel
name: Mambo Moyo
name: Munyaradzi Shumba
Publisher: name: Figshare
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Figure S1. Plot of log Ipa vs. log v. Figure S2. Plot of log E vs. log v. Figure S3. Effect of storage time of B2O3/MWCNT/GCE on the current response to 10 μM paracetamol. Figure S4. Oxidation signal change of 10 μM paracetamol in the presence of interferences. (DOCX 22 kb)
Permutation orbifolds and holography
Creators: name: Haehl, Felix M.
name: Rangamani, Mukund
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Two dimensional conformal field theories with large central charge and a sparse low-lying spectrum are expected to admit a classical string holographic dual. We construct a large class of such theories employing permutation orbifold technology. In particular, we describe the group theoretic constraints on permutation groups to ensure a (stringy) holographic CFT. The primary result we uncover is that in order for the degeneracy of states to be finite in the large central charge limit, the groups of interest are the so-called oligomorphic permutation groups. Further requiring that the low-lying spectrum be sparse enough puts a bound on the number of orbits of these groups (on finite element subsets). Along the way we also study familiar cyclic and symmetric orbifolds to build intuition. We also demonstrate how holographic spectral properties are tied to the geometry of covering spaces for permutation orbifolds.
description: 47 pages, 4 figures. v2: added comments. v3: minor improvements, published version
Demonstration of viral thymidine kinase inhibitor and its effect on deoxynucleotide metabolism in cells infected with herpes simplex virus.
Creators: name: Dutschman, G E
name: Bobek, M
name: Grill, S P
name: Nutter, L M
name: Sharma, R A
name: Cheng, Y C
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1987

description: The thymidine analog 5'-ethynylthymidine was a potent inhibitor of herpes simplex virus type 1 (strain KOS)-induced thymidine kinase with a Ki value of 0.09 microM. 5'-Ethynylthymidine was less inhibitory against herpes simplex virus type 2 (strain 333)-induced thymidine kinase with a Ki of 0.38 microM and showed no inhibition against human cytosolic thymidine kinase under the conditions tested. The compound was effective against the altered thymidine kinase induced by acyclovir- and bromovinyldeoxyuridine-resistant virus variants. At 100 microM 5'-ethynylthymidine, the cellular pool size of dTTP in herpes simplex virus type 1-infected cells was 5% that of infected cells receiving no drug treatment, while there was no significant effect on the pool sizes of dATP, dGTP, and dCTP. There was a positive correlation between dTTP pools and the intracellular thymidine kinase activity of herpes simplex virus type 1-infected cells. When tested alone, 5'-ethynylthymidine exhibited no antiviral activity, but it antagonized the antiviral efficacy of five compounds which require viral thymidine kinase for their action.
Parameter estimation for binary neutron-star coalescences with realistic noise during the Advanced LIGO era
Creators: name: Berry, Christopher P. L.
name: Mandel, Ilya
name: Middleton, Hannah
name: Singer, Leo P.
name: Urban, Alex L.
name: Vecchio, Alberto
name: Vitale, Salvatore
name: Cannon, Kipp
name: Farr, Ben
name: Farr, Will M.
name: Graff, Philip B.
name: Hanna, Chad
name: Haster, Carl-Johan
name: Mohapatra, Satya
name: Pankow, Chris
name: Price, Larry R.
name: Sidery, Trevor
name: Veitch, John
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Advanced ground-based gravitational-wave (GW) detectors begin operation imminently. Their intended goal is not only to make the first direct detection of GWs, but also to make inferences about the source systems. Binary neutron-star mergers are among the most promising sources. We investigate the performance of the parameter-estimation \edit{(PE)} pipeline that will be used during the first observing run of the Advanced Laser Interferometer Gravitational-wave Observatory (aLIGO) in 2015: we concentrate on the ability to reconstruct the source location on the sky, but also consider the ability to measure masses and the distance. Accurate, rapid sky-localization is necessary to alert electromagnetic (EM) observatories so that they can perform follow-up searches for counterpart transient events. We consider PE accuracy in the presence of \edit{non-stationary}, non-Gaussian noise. We find that the character of the noise makes negligible difference to the PE performance \edit{at a given signal-to-noise ratio}. The source luminosity distance can only be poorly constrained, the median $90\%$ ($50\%$) credible interval scaled with respect to the true distance is $0.85$ ($0.38$). However, the chirp mass is well measured. Our chirp-mass estimates are subject to systematic error because we used gravitational-waveform templates without component spin to carry out inference on signals with moderate spins, but the total error is typically less than $10^{-3} M_\odot$. The median $90\%$ ($50\%$) credible region for sky localization is $\sim600~\mathrm{deg^{2}}$ ($\sim150~\mathrm{deg^{2}}$), with $3\%$ ($30\%$) of detected events localized within $100~\mathrm{deg^{2}}$. Early aLIGO, with only two detectors, will have a sky-localization accuracy for binary neutron stars of hundreds of square degrees; this makes EM follow-up challenging, but not impossible.
description: 21 pages, 24 figures. Matches published version. Data release at http://www.ligo.org/scientists/first2years/
title: User-reconfigurable CAD Feature Recognition in 1- and 2-topologies with Reduction of Search Space via Geometry Filters
Creators: name: Corcho, Juan Camilo Pareja
name: Acosta, Oscar Mauricio Betancur
name: Ruiz, Oscar E.
name: Cadavid, Carlos
Publisher: name: The Eurographics Association
Year: 2019
Subjects: Applied computing
Computer
aided design
aided manufacturing

description: In the context of Computer-Aided Design and Manufacturing, the problem of feature recognition plays a key role in the integration of systems. Until now, compromises have been reached by only using FACE-based geometric information of prismatic CAD models to prune the search domain. This manuscripts presents a feature recognition method which more aggressively prunes the search space with reconfigurable geometric tests. This reconfigurable approach allows to enforce arbitrary confluent tests which are topologic and geometric, with enlarged domain. The test sequence is itself a graph (i.e. not a linear or total-order sequence). Unlike the existing methods which are FACE-based, the present one permits combinations of topologies whose dimensions are 2, 1 or 0. This system has been implemented in an industrial environment. The industrial incarnation allows industry-based customization and is faster when compared to topology-based feature recognition. Future work is required in improving robustness of search conditions and improving the graphic input interface.
description: Spanish Computer Graphics Conference (CEIG)
description: Short Papers
description: 69
description: 72
description: Juan Camilo Pareja Corcho, Oscar Mauricio Betancur Acosta, Oscar E. Ruiz, and Carlos Cadavid
description: CCS Concepts: Applied computing--> Computer-aided design; Computer-aided manufacturing
Novel acyclic adenosine analogs inhibit Epstein-Barr virus replication.
Creators: name: DeClercq, E
name: Pagano, J S
name: Lin, J C
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1987

description: The effect of three new acyclic adenosine analogs, (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine [(S)-HPMPA], 9-(2-phosphonylmethoxyethyl)adenine (PMEA), and (S)-9-(2,3-dihydroxypropyl)adenine [(S)-DHPA], on Epstein-Barr virus (EBV) replication was studied. Both (S)-HPMPA and PMEA but not (S)-DHPA effectively inhibited EBV DNA replication in virus-producer P3HR-1 cells and in latently infected Raji cells superinfected with P3HR-1 virus, as determined by cRNA-DNA hybridization and density gradient centrifugation. The 50% effective doses for inhibiting virus replication were 0.08 and 1.1 microM for (S)-HPMPA and PMEA, respectively. Both drugs were cytostatic but not cytotoxic to the cells at a concentration as high as 100 microM. These results indicate that (S)-HPMPA and PMEA are potent and selective anti-EBV agents in vitro.
LOSS's First Supernova? New Limits on the "Impostor" SN 1997bs
Creators: name: Adams, Scott M.
name: Kochanek, C. S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present new, late-time Hubble Space Telescope and Spitzer Space Telescope observations of the archetypal supernova (SN) impostor SN 1997bs. We show that SN 1997bs remains much fainter than its progenitor, posing a challenge for the canonical picture of late-time obscuration by dust forming in a shell ejected during the transient. The possibility that the star survived cloaked behind a dusty, steady wind is also disfavored. The simplest explanation is that SN 1997bs was a subluminous Type IIn SN, although it is currently impossible to rule out the possibility that the star survived either behind an obscuring dusty shell $\gtrsim 1 M_{\odot}$ or with a significantly decreased intrinsic luminosity. Continued monitoring of the system is the most promising means of ultimately resolving the question.
description: 15 pages, 7 figures, 3 tables. For a brief video summarizing the paper see http://youtu.be/knTbsr2QSCM
Peritoneal transport of cefonicid.
Creators: name: Lane, T
name: Morse, G D
name: Gal, P
name: Curry, J
name: Nairn, D K
name: Deterding, J
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1987

description: The pharmacokinetic characteristics of cefonicid, a highly protein-bound expanded-spectrum cephalosporin, were examined in six noninfected, clinically stable patients undergoing continuous ambulatory peritoneal dialysis. After a 1.0-g intravenous dose of cefonicid, the mean concentrations in serum were 105 +/- 25 and 35.6 +/- 14.4 micrograms/ml at 3 and 72 h, respectively. Despite a prolonged half-life in serum of 49.7 +/- 18 h, the penetration into peritoneal fluid was low. The average concentration in dialysate over the 72-h study period was 2.7 micrograms/ml. The serum clearance was 2.6 +/- 1.0 ml/min, and the distribution volume was 0.14 +/- 0.02 liter/kg. Dosage recommendations and clinical considerations for cefonicid use in continuous ambulatory peritoneal dialysis patients are discussed.
Factors that Determine Apparatus Performance Improvement in Realizing Good Governance
Creators: name: Hamson, Zulkarnain
Publisher: name: figshare
Year: 2020
Subjects: subject: 160205 Police Administration, Procedures and Practice
subject: FOS: Law

description: Improved apparatus performance is needed to support the realization of Good Governance, therefore it is necessary to look at the factors that determine the Apparatus Performance Improvement. The purpose of this study is to analyze the factors that determine the improvement of the performance of the state apparatus in realizing good governance in Luwu Regency. The research method used is descriptive method with the object of research is a local government organization that includes, Agency, Offices and Work Units in Luwu Regency. Furthermore, the sample size of each agency is determined proportionally on the basis of the large population in each agency regarding the program and the results of the agency's performance evaluation. The minimum sample size is 98 respondents. The results of the study showed the availability of funds to support the implementation of public service tasks in Luwu Regency government agencies had been carried out properly, increased apparatus performance by increasing public trust in agencies, transparency, accountability of officials, and service certainty had been carried out by district government agencies Luwu well.
Pelatihan Kehumasan dan Media Bagi Staf Bawaslu Provinsi Sulawesi Selatan
Creators: name: Hamson, Zulkarnain
Publisher: name: figshare
Year: 2019
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications

description: Keberhasilan pemilu di Indonesia hanya akan terwujud jika Bawaslu sebagai pengawas bekerja maksimal
TESS Spots a Hot Jupiter with an Inner Transiting Neptune
Creators: name: Vanderspek, R.K.
name: Latham, D.W.
name: Gandolfi, D.
name: Seager, S.
name: Winn, J.N.
name: Georgieva, I.
name: Burke, C.J.
name: Barkaoui, K.
name: Gonzales, E.J.
name: Rose, M.E.
name: Torres, G.
name: Jensen, E.L.N.
name: Schlieder, J.E.
name: Matthews, E.
name: Goeke, R.F.
name: Henry, T.J.
name: Rinehart, S.
name: Ting, E.B.
name: Paredes, L.A.
name: Lissauer, J.J.
name: Huang, C.X.
name: Crossfield, I.
name: Vanderburg, A.
name: Jenkins, J.M.
name: Tan, T.-G.
name: Persson, C.M.
name: Ricker, G.R.
name: Jao, W.-C.
name: Günther, M.N.
name: Fridlund, M.
name: Collins, K.I.
name: Sha, L.
name: Howell, S.B.
name: Shporer, A.
name: Collins, K.A.
name: Mathur, S.
name: Quinn, S.N.
name: Pozuelos, F.J.
name: Jehin, E.
name: Kane, S.R.
name: Palle, E.
name: Mann, A.W.
name: Matson, R.A.
name: Rodriguez, J.E.
name: Eylen, V.V.
name: James, H.-S.
name: Stassun, K.G.
name: Gillon, M.
name: Zhou, G.
name: Becker, J.
name: Wong, I.
Publisher: name: Institute of Physics Publishing
Year: 2020

description: Hot Jupiters are rarely accompanied by other planets within a factor of a few in orbital distance. Previously, only two such systems have been found. Here, we report the discovery of a third system using data from the Transiting Exoplanet Survey Satellite (TESS). The host star, TOI-1130, is an eleventh magnitude K-dwarf in Gaia G-band. It has two transiting planets: A Neptune-sized planet (3.65 ± 0.10) with a 4.1 days period, and a hot Jupiter with an 8.4 days period. Precise radial-velocity observations show that the mass of the hot Jupiter is For the inner Neptune, the data provide only an upper limit on the mass of 0.17 (3σ). Nevertheless, we are confident that the inner planet is real, based on follow-up ground-based photometry and adaptive-optics imaging that rule out other plausible sources of the TESS transit signal. The unusual planetary architecture of and the brightness of the host star make TOI-1130 a good test case for planet formation theories, and an attractive target for future spectroscopic observations.
Are inner disc misalignments common? ALMA reveals an isotropic outer disc inclination distribution for young dipper stars
Creators: name: Hedges, C.
name: Ansdell, M.
name: Rizzuto, A.C.
name: Mann, A.W.
name: Esplin, T.L.
name: Tazzari, M.
name: Wyatt, M.C.
name: Williams, J.P.
name: Duchene, G.
name: Carpenter, J.
name: Kraus, A.L.
name: Kennedy, G.M.
name: Mamajek, E.E.
name: Angelo, I.
name: Gaidos, E.
Publisher: name: Oxford University Press
Year: 2020

description: Dippers are a common class of young variable star exhibiting day-long dimmings with depths of up to several tens of per cent. A standard explanation is that dippers host nearly edge-on (id ≈ 70°) protoplanetary discs that allow close-in (<1 au) dust lifted slightly out of the mid-plane to partially occult the star. The identification of a face-on dipper disc and growing evidence of inner disc misalignments brings this scenario into question. Thus, we uniformly (re)derive the inclinations of 24 dipper discs resolved with (sub-)mm interferometry from ALMA.We find that dipper disc inclinations are consistent with an isotropic distribution over id ≈ 0-75°, above which the occurrence rate declines (likely an observational selection effect due to optically thick disc mid-planes blocking their host stars). These findings indicate that the dipper phenomenon is unrelated to the outer (>10 au) disc resolved by ALMA and that inner disc misalignments may be common during the protoplanetary phase. More than one mechanism may contribute to the dipper phenomenon, including accretion-driven warps and 'broken' discs caused by inclined (sub-)stellar or planetary companions.
PENYULUHAN POLA KOMUNIKASI DAN LITERASI KESEHATAN SEKSUAL REMAJA DI KOTA MAKASSAR
Creators: name: Hamson, Zulkarnain
Publisher: name: figshare
Year: 2020
Subjects: subject: 160503 Communications and Media Policy
subject: FOS: Political science
subject: 169903 Studies of Asian Society
subject: FOS: Sociology

description: The term communication pattern is commonly referred to as a model but the intention is the same, namely a system consisting of various components related to each other to achieve goals. Communication patterns in the community can be used as a way t o e x a m i n e t h e a p p l i c a t i o n o f c o m m u n i c a t i o n t h a t i s b u i l t a n d r u n n i n g , a l s o characterizes the life of the organization. Many activities are carried out to identify how communication patterns can be applied in the community. An understanding of what is meant by communit y is needed. Community definition is a group of people who are members of a forum or organization that has a specific purpose because of the same background of interest. In the community there is an interaction process. Community Service Activities (PKM) a ims to provide knowledge as well as direction, to adolescents who are members of the Makassar Literacy Addict Community, in order to help them recognize health literacy, which has been a reading, and also know how communication patterns are formed within t he community
Role of extracellular iron in the action of the quinone antibiotic streptonigrin: mechanisms of killing and resistance of Neisseria gonorrhoeae.
Creators: name: Bean, K
name: McKenna, W
name: Svendsen, T
name: Adams, J
name: Sparling, P F
name: Chai, Y
name: Britigan, B E
name: Cohen, M S
name: Hassett, D J
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1987

description: The quinone antibiotic streptonigrin is believed to kill bacteria by promoting formation of oxygen radicals. This antibiotic has also been used to select resistant bacterial mutants, some of which vary in iron utilization. We examined the effects of streptonigrin on Neisseria gonorrhoeae and several types of gonococcal mutants. Streptonigrin (0.025 microgram/ml) efficiently killed gonococcal strain FA1090, and this effect depended on iron. Streptonigrin-resistant mutant FA6271 had normal iron uptake but was moderately deficient in total iron. Resistance most likely resulted from failure of FA6271 to divert electrons to streptonigrin, as demonstrated by a reduction in KCN-insensitive respiration (a hallmark of the action of quinones) and superoxide formation. Other mutants selected for inability to use human iron-binding proteins (strains FA6273 and FA6275) had no increase in streptonigrin MIC and no decrease in KCN-insensitive respiration. Mutants did not demonstrate an increase in superoxide dismutase or catalase. Streptonigrin killing of gonococci depended on a reaction(s) in which extracellular iron was important, presumably because iron was required for catalysis of hydroxyl radical. The results suggest that a membrane component may be a target for the actions of streptonigrin.
Impact of stellar population synthesis choices on forward modelling-based redshift distribution estimates
Creators: name: Tortorelli, Luca
name: McCullough, Jamie
name: Gruen, Daniel
Publisher: name: arXiv
Year: 2024
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The forward modelling of galaxy surveys has recently gathered interest as one of the primary methods to achieve the required precision on the estimate of the redshift distributions for stage IV surveys. One of the key aspects of forward modelling a galaxy survey is the connection between the physical properties drawn from a galaxy population model and the intrinsic SEDs, achieved through SPS codes (e.g. FSPS). However, SPS requires a large number of detailed assumptions on the constituents of galaxies, for which the model choice or parameter values are currently uncertain. In this work, we perform a sensitivity study of the impact that the variations of the SED modelling choices have on the mean and scatter of the tomographic galaxy redshift distributions. We assumed the Prospector beta model as the fiducial input galaxy population model and used its SPS parameters to build 9 bands magnitudes of a fiducial sample of galaxies. We then built samples of galaxy magnitudes by varying one SED modelling choice at a time. We modelled the colour redshift relation of these galaxy samples using the SOM approach. We placed galaxies in the SOM cells according to their observed frame colours and used their cell assignment to build colour selected tomographic bins. Finally, we compared each variant's binned redshift distributions against the estimates obtained for the fiducial model. We find that the SED components related to the IMF, AGNs, gas physics, and the attenuation law substantially bias the mean and the scatter of the tomographic redshift distributions with respect to those estimated with the fiducial model. Regardless of the applied stellar mass function based re-weighting strategy, the bias in the mean and the scatter of the tomographic redshift distributions are greater than the precision requirements set by next-generation Stage IV galaxy surveys, such as LSST and Euclid.
description: Accepted for publication in A&A. 29 pages, 12 figures
title: A Virtual Reality Front-End for Earthquake Simulation
Creators: name: Fita, Josep Lluis
name: Besuievsky, Gonzalo
name: Patow, Gustavo A.
Publisher: name: The Eurographics Association
Year: 2019
Subjects: Computing methodologies
Physical simulation
Applied computing
Virtual Reality

description: Virtual Reality has traditionally been used in Cultural Heritage for giving to the final user an immersive experience over recreated scenarios, which usually have been designed and focused on static environment recreation. In spite of its importance for cultural heritage, we have found a lack of virtual reality applications to recreate structural and seismic simulations on historical buildings. In this paper we describe a low-cost virtual reality solution, affordable for all kinds of users that own a smart-phone. Through our application, the users can have an immersive experience that combines the ancient building recreation, its structural simulation and the natural phenomena simulation like earthquakes.
description: Spanish Computer Graphics Conference (CEIG)
description: Full Papers
description: 59
description: 67
description: Josep Lluis Fita, Gonzalo Besuievsky, and Gustavo A. Patow
description: CCS Concepts: Computing methodologies--> Physical simulation; Applied computing--> Virtual Reality