cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Supplementary Material for: Increased Activity and Number of Epidermal Melanocytes in Lesional Psoriatic Skin
Creators: name: Abdel-Naser, M.B.
name: Liakou, A.I.
name: Elewa, R.
name: Hippe, S.
name: Knolle, J.
name: Zouboulis, C.C.
Publisher: name: Karger Publishers
Year: 2016
Subjects: Medicine

description: Background: Psoriatic lesions may resolve with hypo- or hyperpigmentation. The involvement of melanocytes in this dichotomous clinical outcome is not fully investigated. Objectives: Qualitative and quantitative assessment of melanocytes in untreated lesional and non-lesional psoriatic skin (n = 15) and healthy controls (n = 10). Methods: Skin biopsies were labelled immunohistochemically (APAAP technique) with the antimelanocyte monoclonal antibodies (MoAbs) HMB45, Melan A, tyrosinase and microphthalmia-associated transcription factor (MITF). The labelled melanocytes were evaluated by an independent investigator with a digital image analyser. Results: Lesional melanocytes, in contrast to those in non-lesional and healthy skin, exhibited features of activation in the form of dilatation, prominent and long dendrites and intense labelling. The number of melanocytes was significantly increased in psoriatic lesions in comparison with non-lesional psoriatic and healthy skin as shown by counts of cells labelled with the MoAbs HMB45 (3-fold; p < 0.001), Melan A (1.6-fold; p < 0.01) and tyrosinase (1.5-fold; p < 0.01). In contrast, labelling with MITF revealed no significant difference (1.2-fold increase; p > 0.05). Likewise, no significant difference between non-lesional psoriatic and healthy skin control was found (p > 0.05). Furthermore, no positively labelled dermal cells were detected, apart from few only detected with Melan A. Conclusions: Epidermal melanocyte activity and numbers are increased in the epidermal compartment of psoriatic lesions providing an explanation for postinflammatory hyperpigmentation.
Saxo-Norman occupation at Beckenham, Kent?
Creators: name: Harward, Chiz
name: Blackmore, Lyn
name: Keily, Jackie
name: Whittingham, Lucy
Publisher: name: Archaeology Data Service
Year: 2004

description: London Archaeologist, 10 (7), 171-178
description: Possible evidence for farmstead or similar occupation during this period -- though somewhat ambiguous dating evidence. There are notes on
Resolution of the Early Jurassic actinopterygian fish Pachycormus and a dispersal hypothesis for Pachycormiformes
Creators: name: Wretman, Lovisa
name: Blom, Henning
name: Kear, Benjamin P.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: The Early Jurassic (Toarcian) actinopterygian Pachycormus is a basal taxon within Pachycormiformes, a Mesozoic marine neopterygian radiation that evolved an extreme ecomorph divergence between hyperspecialized ‘billfish-like’ macrocarnivores and gigantic suspension feeders, including the largest fish of all time. Current phylogenies place Pachycormus as an early member of the suspension-feeding lineage; however, species disparity renders character states uncertain and potential exists for considerable intraspecific variability. Given its importance for resolution of pachycormiform phylogenetic topology, we comprehensively reassessed Pachycormus fossils housed in collections across Europe and found that the proportional traits traditionally used to discriminate between species are actually consistent with an ontogenetic size morphocline. Our cladistic analyses further show that the monotypic senior synonym, Pachycormus macropterus, is a wildcard that manifests a mosaic of transitional states. This has significant implications for hypothesized Toarcian marine vertebrate provincialism because P. macropterus had a ubiquitous Boreal Tethyan distribution. Moreover, our tree-based palaeobiogeographical optimizations infer that the western Tethyan region was a pachycormiform dissemination center, with global dispersals occurring through transoceanic migration and invasion of epeiric basins. Citation for this article: Wretman, L., H. Blom, and B. P. Kear. 2016. Resolution of the Early Jurassic actinopterygian fish Pachycormus and a dispersal hypothesis for Pachycormiformes. Journal of Vertebrate Paleontology. DOI: 10.1080/02724634.2016.1206022.
Middle Saxon remains at Covent Garden
Creators: name: Taylor, Jeremy
Publisher: name: Archaeology Data Service
Year: 2005

description: London Archaeologist, 10 (8), 199-203
description: Presents the results of excavations in the basement of an existing building at 33 Floral Street, Covent Garden. Evidence was revealed relating to the Middle Saxon period, including stakeholes, pits and postholes, and gravel surfaces representing an external courtyard area. Significant finds included a bone comb, a ceramic loomweight marked by textile and other impressions, and the first example of a copper-alloy sword pommel cap from Lundenwic. Post-medieval features included postholes, brick drains and mortar bedding for a brick floor.
Nothrholaspis tardus
Creators: name: Kontschán, Jenő
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Mesostigmata
Macrochelidae
Nothrholaspis
Nothrholaspis tardus

description: Nothrholaspis tardus (C.L. Koch, 1841)
 Gamasus tardus C. L. Koch, 1841: 14.
 Occurrences. Bátorliget, Kaposvár, Kőszeg, Lillafüred, Sári, Sopron, Szár, Velence, Zalavár, (Erőss and Mahunka, 1971a), Oroszlány (Salmane and Kontschán, 2005), Kőszeg, Nagyrécse, Tatárszentgyörgy, Lipót, Villány (Kontschán, 2006).
description: Published as part of Kontschán, Jenő, 2020, Checklist of the Hungarian species of family Macrochelidae (Acari: Mesostigmata), pp. 7-17 in Acarological Studies 2 (1) on page 10
Samuel Long's House, a lost Carshalton mansion
Creators: name: Hawkins, Duncan
name: Skelton, Andrew
name: Bagwell, Mark
name: Lowe, Jon
Publisher: name: Archaeology Data Service
Year: 2005

description: London Archaeologist, 10 (8), 204-213
description: A watching brief in 2001 at the site of the old Cottage Hospital at 85--105 Rochester Road, Carshalton, revealed fragmentary building remains probably originating in the fourteenth century, with substantial extensions in the eighteenth century. The site was the location of a large mansion house demolished in 1822. The article details the documentary, cartographic and pictorial evidence before describing the archaeological evidence.
Computational analysis on conformational dynamics of bone morphogenetic protein-2 (BMP-2)
Creators: name: Tasneem Kausar
name: Nayeem, Shahid M.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified

description: BMP-2 is widely used for bone regeneration because of its ability to induce osteoblast differentiation and proliferation. The pharmaceutical application of BMP-2 as bone implant makes the studies on stability and conformational dynamics very relevant as proteins are functional only in their native three-dimensional state. Knowing the factors affecting BMP-2 structure becomes essential for designing bone implants activated by BMP-2. In order to explore the influence of temperature and hydration on protein conformation, we have performed the molecular dynamics (MD) simulations at the time scale of 100 ns with two different force fields. We have examined the dynamic behaviour of BMP-2 monomer and dimer in aqueous medium as well as in vacuum at four different temperatures (300, 350, 400 and 450 K). MD simulation of BMP-2 monomer and dimer in water and vacuum environments shows the major contribution of water in structure stabilization. Temperature of the system affects the secondary structure differently in case of monomer and dimer simulation and the dynamics also depends on the environment viz. vacuum and aqueous. Vacuum simulations show very early loss of the major secondary structure content. On the other hand, BMP-2 monomer and dimer in aqueous environment show the unfolding of α-helix with increasing temperature. This unfolded α-helix is converted into β-sheet at 400 K in monomer of BMP-2. Contrary to this, we did not observe β-sheet formation in dimer BMP-2 even at 450 K indicating that monomers are more aggregation prone entity as compared to dimers of BMP-2.
Three new long-chain polyenes from the mangrove-derived fungus Penicillium herquei JX4
Creators: name: Long, Kai-Yuan
name: Dai, De-Cai
name: Zheng, Cai-Juan
name: Wang, Yi-Tong
name: Song, Xin-Ming
name: Chen, Xuan
name: Zhou, Xue-Ming
name: Chen, Guang-Ying
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Hematology
subject: Virology

description: One new epimer pair of long-chain polyenes penicilqueis E (1) and F (2), and one new long-chain polyene pinophol G (3), along with one known compound (4), were obtained from EtOAc extract of the mangrove-derived fungus Penicillium herquei JX4. Their structures were elucidated by detailed analysis of comprehensive spectroscopic data. The inhibitory activities of all compounds against the nitric oxide (NO) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells in vitro were evaluated.
Supplementary document for Inverse design of vanadium dioxide based dynamic structural color via conditional generative adversarial networks - 5981445.pdf
Creators: name: Dai, Peng
name: Sun, Kai
name: Muskens, Otto
name: de Groot, C.
name: Huang, Ruomeng
Publisher: name: Optica Publishing Group
Year: 2022
Subjects: Uncategorized

description: Supporting Information
Portal vein thrombosis in cirrhotic and non cirrhotic patients: from diagnosis to treatment
Creators: name: Dell’Era, Alessandra
name: Seijo, Susana
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Introduction: Portal vein thrombosis (PVT) may occur in non-cirrhotic and cirrhotic patients. It can be classified as acute (if a recent thrombus is present) and chronic (if portal cavernoma has developed). Patients can be symptomatic or may present signs and symptoms related to the development of portal hypertension. In rare cases bowel infarction may occur. Areas covered: This review provides an overview of the clinical presentation, complications, diagnostic challenges and available treatments for PVT in non-cirrhotic and cirrhotic patients (NCPVT). Expert opinion: Treatment of acute NCPVT aims at recanalizing the thrombosed veins and preventing intestinal infarction and portal hypertension. Anticoagulation should be started promptly and maintained for at least 6 months. Long-term anticoagulation should be implemented in the presence of underlying persistent thrombotic state. In chronic NCPVT, treatment aims at managing portal hypertension and portal cavernoma cholangiopathy and preventing new thrombotic events. In this setting, the indication for anticoagulation should be individualized. No formal recommendations can be given for PVT in cirrhosis, since there are no randomized controlled trials, prospective studies, or ad hoc guidelines. High quality studies, including randomized controlled trials, will be needed to provide robust evidence on the best treatment strategy.
Testing the usefulness of the number needed to treat to be harmed (NNTH) in benefit-risk evaluations: case study with medicines withdrawn from the European market due to safety reasons
Creators: name: Mendes, Diogo
name: Alves, Carlos
name: Marques, Francisco Batel
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy

description: Objective: To explore the usefulness of number needed to treat to be harmed (NNTH), in benefit-risk assessments, by studying the agreement between NNTH values and withdrawals of medicines from European market due to safety reasons. Methods: Medicines with data from longitudinal studies were included. Studies were identified from European Medicines Agency’s Reports. Meta-analyses were performed to pool odds ratios (OR) with 95% confidence-intervals (CI). Published control event rates were applied to ORs to calculate NNTHs (95%CI) for selected adverse events. Results: NNTH (95%CI) decreased from pre- to post-marketing for the eight medicines included: peripheral neuropathy (∞ vs. 12[non-significant; NS] with almitrine; heart valve disease with benfluorex (∞ vs. NNTH ranging from 7[4–13] to 7[5–9]); myopathy (−4096[NS] vs. 797[421–1690]), new-onset diabetes (113[NS] vs. 390[425–778]), bleeding (∞ vs. 517[317–1153]), and infection (∞ vs. 253[164–463]) with niacin-laropiprant; psychiatric disorders (12[7–34] vs. 9[5–24]) with rimonabant; myocardial infarction (MI) [−1305 vs. 270[89–4362]) with rofecoxib; MI (−510 vs. NNTH ranging from 152[55–4003] to 568[344–1350]) with rosiglitazone; cardiovascular events (∞ vs. 245[129–1318]) with sibutramine; and liver injury (∞ vs. 5957[NS]) with ximelagatran. Conclusion: NNTH have potential of use as a supportive tool in benefit-risk re-evaluations of medicines and may help regulators to making decisions on drug safety.
O'ZBEKISTON RESPUBLIKASIDA ONLAYN NIZOLARNI HAL QILISHNING HUQUQIY ASOSLARINI YANADA TAKOMILLASHTIRISH: MUAMMO VA ISTIQBOLLAR
Creators: name: Bosimbekov, Umrzoq
Publisher: name: Zenodo
Year: 2024

description: Mazkur tezisda O‘zbekiston Respublikasida onlayn nizolarni hal qilish tizimlarini rivojlantirish uchun huquqiy asoslarni takomillashtirish muammolari va istiqbollari tahlil qilingan. Hozirda O‘zbekistonda onlayn nizolarni hal qilish uchun yetarli huquqiy asoslar, zamonaviy texnologik infratuzilma, raqamli savodxonlik darajasi va internet aloqasining barqarorligi yetishmaydi. Muammolarni hal etish uchun yangi qonunlar qabul qilish, texnologik platformalarni joriy etish, raqamli savodxonlikni oshirish va xalqaro hamkorlikni kuchaytirish zarur. Bu tizimlarni rivojlantirish huquqiy samaradorlikni oshiradi va iqtisodiy-ijtimoiy rivojlanishga hissa qo‘shadi.
Synthesis of novel 1,4-disubstituted 1,2,3-triazoles bearing organosilicon-sulfur groups via the click reaction sonocatalyzed by LaCuxMn1-xO3 nanoparticles
Creators: name: Safa, Kazem D.
name: Hanieh Mousazadeh
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified

description: A highly efficient and environmentally friendly one-pot procedure for the synthesis of 1,2,3-triazoles by 1,3-dipolar cycloaddition of benzyl halides, terminal alkynes, and sodium azide over LaCuxMn1-xO3 perovskite oxides was developed. LaCu0.7Mn0.3O3 was found to be active with low catalyst loading under ultrasonic irradiation in aqueous media. The reaction was performed efficiently in the presence of the nanocatalyst in the absence of any additive or base with a noticeable reduction in the reaction time. The catalyst could be recycled and reused at least five times without any significant effect on the results of the reaction. Moreover, a series of novel organosilicon-sulfur substituted 1,2,3-triazole derivatives was synthesized using carbon disulfide and tris(trimethylsilyl)methylithium.
Synthesis of Novel 1,4-disubstituted 1,2,3-triazoles Bearing Organosilicon-sulfur Groups via the Click Reaction Sonocatalyzed by LaCuxMn1-xO3 Nanoparticles
Creators: name: Safa, Kazem D.
name: Hanieh Mousazadeh
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified

description: A high efficient and environmentally friendly one-pot procedure for the synthesis of 1,2,3-triazoles by 1,3-dipolar cycloaddition of benzyl halides, terminal alkynes and sodium azide over LaCuxMn1-xO3 perovskite oxides was developed. LaCu0.7Mn0.3O3 was found to be active with low catalyst loading under ultrasonic irradiation in aqueous media. The reaction was performed efficiently in the presence of the nanocatalyst in the absence of any additive or base with a noticeable reduction in the reaction time. The catalyst could be recycled and reused at least five times without any significant effect on the results of the reaction. Moreover, a series of novel organosilicon-sulfur substituted 1,2,3-triazole derivatives was synthesized using carbon disulfide and tris(trimethylsilyl)methylithium.
title: Evaluation of the impact of Ultra Low Dose Chest Computed Tomography in the antibiotics prescription in patients with suspected community-acquired pneumonia - Preliminary data
Creators: name: CARUSO CHATE, RODRIGO
Publisher: name: European Society of Thoracic Imaging
Year: 2019
Subjects: subject: CT-High Resolution
subject: CT
subject: Conventional radiography
subject: Thorax
subject: Respiratory system
subject: Lung
subject: Comparative studies
subject: Image verification

description: Purpose Methods Materials Results Conclusion References Personal Information
description: Purpose: This study was designed to evaluate patients with acute couth in emergency department (ED), using an active investigation to discharge community-acquired pneumonia (CAP). Nowadays the Currently standard strategy for the diagnostic of CAP is based in...
Iridoids and phenylethanoid glycosides from the aerial parts of Ajuga tenorei, an endemic Italian species
Creators: name: Frezza, Claudio
name: Venditti, Alessandro
name: Cecco, Mirella Di
name: Ciaschetti, Giampiero
name: Serafini, Mauro
name: Armandodoriano Bianco
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology

description: We report the first analysis in absolute, and in particular, concerning the phytochemical pattern, about an endemic Italian species, Ajuga tenorei C. Presl. The analysis, performed by means of techniques such as Column Chromatography and NMR spectroscopy and Mass spectrometry, led to the isolation and the identification of five compounds namely verbascoside (1), echinacoside (2), ajugoside (3), harpagide (4) and 8-O-acetylharpagide (5). The presence of these compounds is important from both chemotaxonomic and ethno-pharmacological point of view. For what concerns the first point is confirmed the correct botanical classification of the species. The isolated compounds are also known to exert peculiar pharmacological activities and their presence may give a rationale to the historical medicinal properties associated to the Ajuga genus in general, since these plants have a long traditional use in many parts of the world. Such fact might suggest the use of also this species in this sense.
title: LDCT lung cancer screening in populations at different risk for lung cancer
Creators: name: CARUSO CHATE, RODRIGO
Publisher: name: European Society of Thoracic Imaging
Year: 2019
Subjects: subject: Cancer
subject: Diagnostic procedure
subject: CT
subject: Thorax
subject: Respiratory system
subject: Lung

description: Purpose Methods Materials Results Conclusion References Personal Information
description: Purpose: To compare the initial results of lung cancer screening using low dose computed tomography (LDCT) in two populations at different risk for lung cancer (high risk versus low/moderate...
Additional file 2: of Protective immunity induced by Eimeria common antigen 14–3-3 against Eimeria tenella, Eimeria acervulina and Eimeria maxima
Creators: name: Liu, Jianhua
name: Liu, Lianrui
name: Li, Lingjuan
name: Tian, Di
name: Li, Wenyu
name: Xu, Lixin
name: Yan, Ruofeng
name: Li, Xiangrui
name: Song, Xiaokai
Publisher: name: figshare
Year: 2018
Subjects: subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Table S1. Amino acid similarities of 14–3-3 between E. acervulina, E. maxima, E. tenella, E. necatrix (%). 1.Ea14–3-3 = 14–3-3 of E. acervulina; Em14–3-3 = 14–3-3 of E. maxima; Et14–3-3 = 14–3-3 of E. tenella; En14–3-3 = 14–3-3 of E. necatrix. (DOCX 16 kb)
title: Lung ultrasound in pulmonary tuberculosis: preliminary results.
Creators: name: Cozzi, Diletta
Publisher: name: European Society of Thoracic Imaging
Year: 2019
Subjects: subject: Infection
subject: Epidemiology
subject: Education and training
subject: Socio-economic issues
subject: Screening
subject: Diagnostic procedure
subject: Ultrasound
subject: CT
subject: Thorax
subject: Lung

description: Purpose Methods Materials Results Conclusion References Personal Information
description: Purpose: Tuberculosis (TB) is a worldwide infection that kills more than 1 million people a year. Diagnosis is made through clinical-laboratoristic findings but imaging plays a key role in the management of these patients. Usually, the main radiological...
title: Diagnostic value of CT – guided transthoracic core, fine needle and the combination of these two biopsy techniques – the study on the base of 993 procedures
Creators: name: Jelitto-Gorska, Malgorzata
Publisher: name: European Society of Thoracic Imaging
Year: 2019
Subjects: subject: Outcomes
subject: Metastases
subject: Cancer
subject: Statistics
subject: FOS: Mathematics
subject: Diagnostic procedure
subject: Biopsy
subject: Percutaneous
subject: Fluoroscopy
subject: CT
subject: Thorax
subject: Respiratory system
subject: Interventional non-vascular

description: Purpose Methods Materials Results Conclusion References Personal Information
description: Purpose: CT guided transthoracic needle biopsy is a widely used technique for diagnosing pulmonary lesions. The aim of the study was to assess the diagnostic value of CT guided core needle biopsy (CNB), fine needle aspiration biopsy (FNAB) and the...
Pew Research Center: Faith Among Black Americans
Creators: name: Pew Research Center
Publisher: name: Roper Center for Public Opinion Research
Year: 2022

description: Satisfaction with life (2); recent participation in local activities (3); reliance on advice when making major life decisions (1); opinion on male vs. female responsibilities (4); opinion on societal issues (4); approval of criminal justice system (1); legalization of abortion (1); importance of race on view of yourself (1); identification with different churches or denominations (2); personal consideration of religious views (5); attendance of religious services (10); agreement with statements regarding religious views (2); how often you do religious activities (3); beliefs regarding God (5); approval of religious leaders performing marriage ceremonies for same-sex couples (1); important features for congregations/houses of worship (1); role of women as senior religious leaders (1); influence of predominantly Black churches on equality in the US (5); recent experiences with racist implications (6).
TA'LIM TIZIMINI RAQAMLASHTIRISHNING XORIJ TAJRIBASI VA UNI O'ZBEKISTONDA QO'LLASH USULLARI
Creators: name: Qodirov, Farrux
name: Mavlonova, Muxlisa
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqolada taʼlim tizimini raqamlashtirish boʻyicha jahon tajribasining qisqacha koʻrinishini va ushbu usullarni Oʻzbekistonda qoʻllash imkoniyatlari haqida fikr yuritiladi. U Finlyandiya, Singapur va Janubiy Koreya kabi mamlakatlarning infratuzilmani rivojlantirish, o‘qituvchilar malakasini oshirish, o‘quv dasturlarini ishlab chiqish va siyosatni shakllantirishga qaratilgan muvaffaqiyatli strategiyalarini ta’kidlaydi.
title: CT-based computational model to assess pulmonary ventilation in COPD patients: Comparison with 129Xe-MRI and SPECT images
Creators: name: Gleeson, Fergus
Publisher: name: European Society of Thoracic Imaging
Year: 2019
Subjects: subject: Image verification
subject: Image guided radiotherapy
subject: Chronic obstructive airways disease
subject: Imaging sequences
subject: Computer Applications-General
subject: Computer Applications-3D
subject: SPECT
subject: MR
subject: CT-High Resolution
subject: Respiratory system
subject: Lung
subject: Computer applications

description: Purpose Methods Materials Results Conclusion References Personal Information
description: Purpose: Thoracic computed tomography (CT) is a clinically established diagnostic technique to detect structural pulmonary abnormalities.Although CT is routinely performed clinically, it provides no functional pulmonary information [3,4]. The current study...
title: Pleural invasion classification of primary lung cancer by 3T MRI with contrast enhanced radial T1-wieghted 3D spoiled gradient echo sequence comparison with CT analysis
Creators: name: Kwon, Woocheol
Publisher: name: European Society of Thoracic Imaging
Year: 2019
Subjects: subject: Lung
subject: MR
subject: Imaging sequences
subject: Cancer

description: Purpose Methods Materials Results Conclusion References Personal Information
description: Purpose: To clarify pleural invasion classification of primary lung cancer by 3T MRI with radial T1-wieghted 3D spoiled gradient echo sequence compared with CT...
title: Lung involvement in Destombes-Rosai-Dorfman disease: clinical and radiological features, and response to the MEK inhibitor cobimetinib
Creators: name: Boussouar, Samia
Publisher: name: European Society of Thoracic Imaging
Year: 2019
Subjects: subject: Computer Applications-Detection, diagnosis
subject: PET-CT
subject: CT
subject: Lung
subject: Inflammation

description: Purpose Methods Materials Results Conclusion References Personal Information
description: Purpose: Destombes-Rosai-Dorfman disease (RDD), first described by Paul Destombes in 1965, was recognized as a distinct clinicopathological entity by Rosai and Dorfman in 1969. RDD is now considered as a distinct non-Langerhans cell histiocytosis group, and...
Synthesis and characterization of β-cyclodextrin/fraxinellone inclusion complex and its influence on interaction with human serum albumin
Creators: name: Yan, Jin
name: Tang, Bin
name: Wu, Di
name: Shanshan Li
name: Kailin Xu
name: Xiaoli Ma
name: Wang, Qing
name: Li, Hui
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Marine Biology
subject: Hematology

description: Aqueous solubility is one of the key determinants in developing new chemical entities as drugs. In this study, to improve the solubility of fraxinellone, a novel β-cyclodextrin/fraxinellone inclusion complex was prepared and characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, X-ray diffraction, and elemental analysis. Moreover, the influence of inclusion of small molecule by cyclodextrins on its binding with transporter in human body is essential for drug development. For the first time, we report the interaction of fraxinellone and its inclusion complex with human serum albumin. Fluorescence quenching of albumin by fraxinellone and its inclusion complex is a static process through complex formation. The results indicated that β-cyclodextrin did not affect the binding force and site of fraxinellone to the protein. Furthermore, circular dichroism showed that both fraxinellone and its inclusion complex induced a significant change in the secondary structure of human serum albumin.
title: Paratexte (4)_Physiologie du goût
Creators: name: AmateurS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Paratexte
description: ID_PARA_00659
title: 01_1319
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Synthesis and characterization of β-cyclodextrin/fraxinellone inclusion complex and its influence on interaction with human serum albumin
Creators: name: Yan, Jin
name: Tang, Bin
name: Wu, Di
name: Shanshan Li
name: Kailin Xu
name: Xiaoli Ma
name: Wang, Qing
name: Li, Hui
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Marine Biology
subject: Hematology

description: Aqueous solubility is one of the key determinants in developing new chemical entities as drugs. In this study, to improve the solubility of fraxinellone, a novel β-cyclodextrin/fraxinellone inclusion complex was prepared and characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, X-ray diffraction, and elemental analysis. Moreover, the influence of inclusion of small molecule by cyclodextrins on its binding with transporter in human body is essential for drug development. For the first time, we report the interaction of fraxinellone and its inclusion complex with human serum albumin. Fluorescence quenching of albumin by fraxinellone and its inclusion complex were static process through complex formation. The results indicated that β-Cyclodextrin did not affect the binding force and site of fraxinellone to the protein. Furthermore, circular dichroism showed that both fraxinellone and its inclusion complex induced a significant change in the secondary structure of human serum albumin.
Kaiser Family Foundation Poll: February 2022 COVID-19 Vaccine Monitor
Creators: name: Kaiser Family Foundation
Publisher: name: Roper Center for Public Opinion Research
Year: 2022

description: Concern about serious illness from coronavirus (1); COVID-19 vaccine (2); news about Omicron variant (2); Centers for Disease Control and Prevention (CDC) recommendations for booster shots (1); what would convince unvaccinated respondents to get vaccinated (1); health insurance coverage (4); political partisanship (2); ideology (1); how often respondent spoke with neighbors prior to pandemic (1); volunteering (1).
Additional file 1: of Exploring factors associated with views on sharing of certain interim trial result measures by the data safety monitoring board (DSMB) with non-DSMB members
Creators: name: Borg Debono, Victoria
name: Mbuagbaw, Lawrence
name: Paul, James
name: Buckley, Norman
name: Thabane, Lehana
Publisher: name: figshare
Year: 2018
Subjects: Space Science
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Science Policy

description: Definitions of interim result measures. (PDF 22 kb)
From medieval malt house to 20th-century pub: excavations at 9-11 Poplar High Street,Lonon E14
Creators: name: Sygrave, Jon
Publisher: name: Archaeology Data Service
Year: 2005

description: London Archaeologist, 10 (8), 215-222
description: Archaeological investigations in 2002 at the site of the former White Horse public house at 9--11 Poplar High Street revealed evidence of medieval and post-medieval settlement. Medieval remains included a fired surface, possibly part of a kiln or oven and itself sealed by backfills which contained pottery sherds dated to between 1240--1350. Subsequently a sequence of probable malting kilns or grain ovens was constructed. A shallow cellar to the north of the kiln sequence may have been a processing area. A charred deposit overlying the floor of the cellar was found to comprise mainly charcoal fragments including twigs and straw. A similar charred deposit from a sixteenth-century pit to the north contained large amounts of straw, cereal chaff and cereal grains. The kilns and cellar were backfilled with a mixture of mortar, brick and tile. A pit cut into the backfill contained pottery dated to the late-sixteenth century, as did two pits in the central area of the site. A tavern called The White Horse stood on the site from 1690 to immediately prior to the investigation. The earlier building was apparently demolished in the eighteenth century, and the debris layer contained a mix of artefacts and pottery, the latter dated to between 1745 and 1770. Also found were two Chinese porcelain bowls, an English porcelain saucer, two London stoneware tankards, a whiteware chamber pot, and three gaming counters made from sherds of tin-glazed ware. Other artefacts included drinking glasses, a small glass bowl and glass bottles. A large assemblage of nineteenth-century ceramics, glass and other finds were recovered from a soakaway and cesspit.
Riparian Barnes revisited
Creators: name: Cowie, Robert
name: Spurr, Graham
Publisher: name: Archaeology Data Service
Year: 2004

description: London Archaeologist, 10 (9), 227-229
description: Summarises the results of fieldwork undertaken on the south bank and foreshore of the River Thames at Barnes by the Museum of London Archaeology Service in 2003--04. Deposits revealed evidence of the sequence of flooding and silting from the Mesolithic period onwards, along with what appears to have been dredged alluvium redeposited as part of nineteenth-century embankment works.
An archaeological watching brief of the exhumation of the Jesuit Cemetery at Manresa House, Roehampton
Creators: name: Melikian, Melissa
Publisher: name: Archaeology Data Service
Year: 2004

description: London Archaeologist, 10 (9), 230-233
description: Summarises the results of an archaeological watching brief during exhumation and relocation of the cemetery to another area of the site. The cemetery was in use from 1867 to 1962. Information recorded included a total of eighty-two headstones; a total of 108 coffins, along with coffin fittings; state of preservation; and burial practices such as orientation, burial positions, vestments, and the proportion of stack burials.
The Little Rose Estate: new insights into the Rose Theatre, Southwark: Part 1
Creators: name: Blatherwick, Simon
name: Pickard, Chris
Publisher: name: Archaeology Data Service
Year: 2004

description: London Archaeologist, 10 (9), 234-244
description: First part of a two-part report on an archaeological/engineering evaluation undertaken at 54 Park Street, London SE1, adjacent to the site of the archaeological remains of the Rose Theatre. The report outlines the aims and objectives of the fieldwork, the planning background and the scope of the works, and the geological and topographical background; gives a brief documentary history of the site of The Rose, along with a summary of cartographic evidence; and the archaeological background, with particular reference to the excavations undertaken at the site in 1988--89.
title: 02_0652
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Utilization of CRISPR-CAS as a Genome Editing Tool to Encode the Notch1-mNeonGreen Fusion Protein in Mammalian Cells
Creators: name: Smith, Natalie Alexa
Publisher: name: Zenodo
Year: 2024
Subjects: DNA editing
DNA technology
CRISPR-Cas9
Notch1
mNeonGreen
mammalian cells

description: Clustered regularly interspaced palindromic repeats (CRISPR-Cas) is an example of DNA editing technology that is naturally found in the immune system of bacteria but has been engineered to edit DNA sequences in mammalian cells. This can be used by medical scientists to treat genetic diseases like sickle cell anemia. The popularity of using CRISPR-Cas has increased due to its ability to add/delete any sequence that is located in a specific site in the genome, called the target sequence. The target sequence chosen for this project was the Notch1 gene that encodes the Notch1 protein, which is part of the Notch signaling pathway vital for the embryonic development of tissues throughout the body. In this project, CRISPR-Cas will be used to generate a new line of mammalian cells by inserting a fluorescent protein sequence (mNeonGreen) into the Notch1 sequence, hopefully creating cells with a Notch1-mNeonGreen fused protein.

Three target sequences were designed to target the Notch1 sequence in the mammalian genome. The target sequences were combined with circular pieces of DNA (plasmids) that contain the Cas9 enzyme to generate a complex that will target and cut the double strands of DNA that encodes the Notch1 protein to insert the mNeonGreen sequence. For future work, the complex with the target sequence and Cas9 enzyme needs to be combined with a plasmid that contains the mNeonGreen sequence, so it can be taken up by mammalian cells, potentially generating a new line of cells that express the Notch1-mNeonGreen fused protein.
title: Notice : Information de l’utilisateur pour le Tivicay 50 mg, comprimés pelliculés : dolutégravir
Creators: name: Leibowitch, Jacques
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Source: http://www.calames.abes.fr/pub/ms/Calames-201931112328303131
description: created: start=1975;end=2018
Biophysical insights into the interaction of hen egg white lysozyme with therapeutic dye clofazimine: modulation of activity and SDS induced aggregation of model protein
Creators: name: Ajmal, Mohammad Rehan
name: Chaturvedi, Sumit Kumar
name: Zaidi, Nida
name: Alam, Parvez
name: Masihuz Zaman
name: Siddiqi, Mohammad Khursheed
name: Nusrat, Saima
name: Jamal, Mohammad Sarwar
name: Mahmoud, Mohamed H.
name: Badr, Gamal
name: Khan, Rizwan Hasan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: The present study details the binding process of clofazimine to hen egg white lysozyme (HEWL) using spectroscopy, dynamic light scattering, transmission electron microscopy (TEM), and molecular docking techniques. Clofazimine binds to the protein with binding constant (Kb) in the order of 1.57 × 104 at 298 K. Binding process is spontaneous and exothermic. Molecular docking results suggested the involvement of hydrogen bonding and hydrophobic interactions in the binding process. Bacterial cell lytic activity in the presence of clofazimine increased to more than 40% of the value obtained with HEWL only. Interaction of the drug with HEWL induced ordered secondary structure in the protein and molecular compaction. Clofazimine also effectively inhibited the sodium dodecyl sulfate (SDS) induced amyloid formation in HEWL and caused disaggregation of preformed fibrils, reinforcing the notion that there is involvement of hydrophobic interactions and hydrogen bonding in the binding process of clofazimine with HEWL and clofazimine destabilizes the mature fibrils. Further, TEM images confirmed that fibrillar species were absent in the samples where amyloid induction was performed in the presence of clofazimine. As clofazimine is a drug less explored for the inhibition of fibril formation of the proteins, this study reports the inhibition of SDS-induced amyloid formation of HEWL by clofazimine, which will help in the development of clofazimine-related molecules for the treatment of amyloidosis.
Diagnostic accuracy of CRISPR technology for detecting SARS-CoV-2: a systematic review and meta-analysis
Creators: name: Li, Xin
name: Zhang, Huiling
name: Zhang, Jing
name: Song, Yang
name: Shi, Xuening
name: Zhao, Chao
name: Wang, Juan
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified

description: To evaluate the diagnostic accuracy of CRISPR-Cas technology for SARS-CoV-2. RT-qPCR is defined as the reference standard. Data was collected and assessed by Quality Assessment of Diagnostic Accuracy Studies (QUADAS)-2 tool. A bivariate model for pooling was employed and subgroups analysis was used to explore heterogeneity. 2264 samples from 28 articles were extracted for evaluating the accuracy of CRISPR technology for diagnosing SARS-CoV-2. The pooled sensitivity and specificity of CRISPR technology were 0.98 (95% CI: 0.95–0.99) and 1.0 (95% CI: 0.98–1.00), respectively. High risks in patient selection bias and unclear risk of index test bias may affect accuracy. Subgroup analysis showed that CRISPR-Cas12 is applicable for molecular diagnostics for its active editing characteristics. RT-LAMP and RT-RPA are usually used for pre-amplification and fluorescence detection to output results quantitatively. Nasopharyngeal swabs and dual-genes perform greatly in our study. The results concluded from all studies showed that CRISPR technology is a promising molecular method for detecting SARS-CoV-2. Standard methods including comparable sample material, patient selection, operating procedure and operators should be established.
title: Chest HRCT findings in former cigarette smokers
Creators: name: Detorakis, Efstathios
Publisher: name: European Society of Thoracic Imaging
Year: 2019
Subjects: subject: Inflammation
subject: Chronic obstructive airways disease
subject: Screening
subject: Diagnostic procedure
subject: Computer Applications-Detection, diagnosis
subject: CT-High Resolution
subject: CT
subject: Thorax
subject: Respiratory system
subject: Lung

description: Purpose Methods Materials Results Conclusion References Personal Information
description: Purpose: The present study aimed to describe chest HRCT findings depicted in former tobacco smokers after years of smoking...