cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Characterization of a New Ribosome Associated Quality  Control Pathway
Creators: name: Barbeau, William
Publisher: name: University of Utah
Year: 2016
Subjects: Ribosomes - Research

description: Proteins are life's double edged sword. Proteins are essential macromolecules of life, and the tasks that some proteins accomplish are quite marvelous. At the same time, if proteins misfold they have the potential to kill the cell that harbors them. It is becoming increasingly clear that proteins have the potential to misfold from the very beginning of their life, during translation. To strike a balance between translational efficiency and accuracy, cells choose between various synonymous codons to regulate translation. Frequent codons are translated more quickly than rare codons, and the usage of frequent and rare codons is used to regulate translation dynamics. The balance between the usage of frequent and rare codons is fine, as synonymous mutations can disrupt the translational machinery enough to abort  translation and degrade the nascent protein. Surprisingly, disruption of the ribosome happens quite frequently, and requires the response of ribosome associated quality control (RQC) to degrade the potentially misfolded proteins. So far only one RQC  pathway has been described that responds to ribosomes that have been stalled for prolonged periods of time. In this study I present a novel RQC pathway where the ribosome is able to recover from stalling. Despite ribosome recovery, the nascent protein  is still targeted for degradation with ubiquitin. I found that previously described RQC components, Ltn1 and Rqc1 are involved in this pathway. Additionally, I begin to characterize how the nascent protein is trafficked from the ribosome to the vacuole. This new RQC pathway further highlights the importance codon usage plays in protein folding and adds a more nuanced view of the genetic code and translation.
Aconteceu na FDULP
Creators: name: Faculdade De Direito Da Universidade Lusófona Do Porto, Revista Da
Publisher: name: UL-P Law Review - Revista de Direito da UL-P
Year: 2012

description: Lista dos mais recentes e relevantes eventos, quer de cariz científico quer de natureza diversa, relacionados com a Universidade Lusófona do Porto, em especial com a Faculdade de Direito
description: UL-P Law Review - Revista de Direito da UL-P, Vol. 1 No. 1 (2012): Revista da Faculdade de Direito da Universidade Lusófona do Porto
Schöfflistorf
Creators: name: Keller, Heinrich
Publisher: name: [s.n.]
Year: 1795
Subjects: Kirchenbau

description: Reformierte Kirche Schöfflisdorf
description: Auf einer Seite in einem Album mit elf weiteren eingeklebten Zeichnungen
description: Das Album hat 73 paginierte Seiten mit 372 eingeklebten Zeichnungen (nach heutiger Zählung 343), seine Entstehungszeit ist unbekannt
Experiences and Perceptions of Iraqi Muslim Refugee Women and Health Care Providers in the Health Care Encounter
Creators: name: Penney, Debra Susan
Publisher: name: University of Utah
Year: 2016

description: Research indicates that health disparities persist for minorities in the U.S. Sources of health disparities may stem from differences (linguistic, cultural, religious, gender, education) between health provider and patient. This qualitative study explored perceptions and experiences between Iraqi Muslim women with refugee backgrounds and primary health care providers in the context of the health encounter. Study design was based on critical ethnography and postcolonial feminism that guided semistructured interviews. Participants were purposefully selected from 4 urban clinics and included 15 Iraqi Muslim women patients with refugee backgrounds and 10 primary health care providers. All 10 provider and 5 patient interviews were conducted in English; 10 Iraqi patient interviews were conducted in Arabic, transcribed in Arabic, and translated into English for analysis. Arabic transcriptions and recordings were verified and the English translations were translated back to Arabic. Supportive methods included field notes, and discussions with key informants. The data were coded and categories were formed from repetition of main ideas. Through analysis and interpretation of the data, themes emerged from the categories for each participant group. Results describe how Iraqi Muslim women face many barriers in seeking health care that are both health system and health provider based. Likewise, health providers are limited in their ability to bridge differences and encounter knowledge deficits about patients as individuals. Both participant groups had expectations of the health encounter constructed on culturally-based perceptions and expectations. The health encounter is limited by time and inadequate interpretive services that narrow opportunities for clear communication and understanding between provider and patient. These factors combined with individual perceptions and expectations open an avenue for misinterpretation, misdiagnosis, and stereotyping. Recommendations are given for improving health services to refugees. These include comprehensive changes to the usual confines of the health encounter and avenues for increasing awareness and education of state agencies, health administration, and health providers about the barriers faced by Iraqi Muslim women. In light of the continued health disparities for minority groups, future research is recommended in order to identify the interpersonal elements that contribute to health disparities for patients who are newly arrived to the U.S.
CARITAS IN VERITATE – Uma encíclica para o desenvolvimento e a globalização
Creators: name: Clemente, Dom Manuel
Publisher: name: UL-P Law Review - Revista de Direito da UL-P
Year: 2012

description: Comunicação apresentada pelo Dom Manuel Clemente no Encontro sobre Filosofia do Direito da Universidade Lusófona do Porto, a 5 de Novembro de 2009
description: UL-P Law Review - Revista de Direito da UL-P, Vol. 1 No. 1 (2012): Revista da Faculdade de Direito da Universidade Lusófona do Porto
Schönenberg
Creators: name: Keller, Heinrich
Publisher: name: [s.n.]
Year: 1795
Subjects: Schönenberg, Kanton Zürich
Kanton Zürich

description: Auf einer Seite in einem Album mit elf weiteren eingeklebten Zeichnungen
description: Das Album hat 73 paginierte Seiten mit 372 eingeklebten Zeichnungen (nach heutiger Zählung 343), seine Entstehungszeit ist unbekannt
Schollenberg von Ost
Creators: name: Keller, Heinrich
Publisher: name: [s.n.]
Year: 1795
Subjects: Flaach

description: Teil der Burgstelle Schollenberg, die 1839 abgetragen wurde
description: Auf einer Seite in einem Album mit elf weiteren eingeklebten Zeichnungen
description: Das Album hat 73 paginierte Seiten mit 372 eingeklebten Zeichnungen (nach heutiger Zählung 343), seine Entstehungszeit ist unbekannt
Schwamendingen
Creators: name: Keller, Heinrich
Publisher: name: [s.n.]
Year: 1795
Subjects: Zürich

description: Reformierte Kirche Schwamendingen vor dem Umbau 1885, bei dem ein höherer Dachreiter aufgesetzt wurde
description: Auf einer Seite in einem Album mit elf weiteren eingeklebten Zeichnungen
description: Das Album hat 73 paginierte Seiten mit 372 eingeklebten Zeichnungen (nach heutiger Zählung 343), seine Entstehungszeit ist unbekannt
Schloss Schwandegg von SSO
Creators: name: Keller, Heinrich
Publisher: name: [s.n.]
Year: 1795
Subjects: Waltalingen

description: Auf einer Seite in einem Album mit elf weiteren eingeklebten Zeichnungen
description: Das Album hat 73 paginierte Seiten mit 372 eingeklebten Zeichnungen (nach heutiger Zählung 343), seine Entstehungszeit ist unbekannt
Schwandegg
Creators: name: Keller, Heinrich
Publisher: name: [s.n.]
Year: 1795
Subjects: Waltalingen

description: Auf einer Seite in einem Album mit elf weiteren eingeklebten Zeichnungen
description: Das Album hat 73 paginierte Seiten mit 372 eingeklebten Zeichnungen (nach heutiger Zählung 343), seine Entstehungszeit ist unbekannt
Seebach : nach Herr'n O. Schulthess Aufnahme 1826
Creators: name: Keller, Heinrich
Publisher: name: [s.n.]
Year: 1826

description: Karte von Zürich-Seebach, sowie eine skizzenartige Ansicht der Alten Reformierten Kirche Seebach
description: Auf einer Seite in einem Album mit elf weiteren eingeklebten Zeichnungen
description: Das Album hat 73 paginierte Seiten mit 372 eingeklebten Zeichnungen (nach heutiger Zählung 343), seine Entstehungszeit ist unbekannt
O processo disciplinar no Estatuto da Ordem dos Advogados portugueses: entre a vertigem de uma estrutura acusatória e a miragem da protecção dos direitos fundamentais do advogado arguido
Creators: name: Neves, Rosa Vieira
Publisher: name: UL-P Law Review - Revista de Direito da UL-P
Year: 2012

description: Abstract:
 The exercise of disciplinary action, for the practice of misconduct by a lawyer or trainee lawyer, is the sole responsibility of the O.A., as professional body representative of their peers. The disciplinary procedure prescribed in the statute of the O.A., presents a framework for an integrated accusatory principle of research. The participation of the rapporteur of the disciplinary proceedings in the voting of the resolution imposing a disciplinary sanction is substantively unconstitutional for violating paragraph 5 of article 32nd of the Portuguese Constitution. The requirement to comply with this legislation stems, ultimately, from the similar nature of the fundamental rights of the accused lawyer or trainee lawyer to the rights, freedoms and guarantees protected in criminal proceedings.
  
 Keywords: disciplinary law, professional association, libelous structure, research principle
description: UL-P Law Review - Revista de Direito da UL-P, Vol. 1 No. 1 (2012): Revista da Faculdade de Direito da Universidade Lusófona do Porto
Schwerzenbach
Creators: name: Keller, Heinrich
Publisher: name: [s.n.]
Year: 1813
Subjects: Kirchenbau

description: Ansicht der 1812-1813 nach Plänen von Hans Conrad Bluntschi errichteten Ovalkirche, allerdings ohne die markanten Rundungen des Ovals, vor dem Bau der Treppenanlange 1817
description: Auf einer Seite in einem Album mit elf weiteren eingeklebten Zeichnungen
description: Das Album hat 73 paginierte Seiten mit 372 eingeklebten Zeichnungen (nach heutiger Zählung 343), seine Entstehungszeit ist unbekannt
Modulating Intestinal Liver X Receptor Activity to Alter the Development of Atherosclerosis in Zebrafish
Creators: name: Astin, M. Holly
Publisher: name: University of Utah
Year: 2016
Subjects: Liver X receptors - Research
Zebrafish - genetics

description: The liver X receptors (LXRs) are important regulators of lipid and cholesterol metabolism and control diverse  pathways in development, reproduction, metabolism,  immunity and inflammation. Thus, LXRs have potential  as therapeutic targets for diseases as diverse as lipid  disorders, atherosclerosis, chronic inflammation, cancer and neurodegenerative diseases. Taking a genetic approach centered on the single LXR gene nr1h3 in zebrafish, we tested the hypothesis that modulating  intestinal LXR activity in intestinal lipid trafficking alters  the development of atherosclerosis. Our lab previously  demonstrated that intestinal LXR over-expression delays the transport of absorbed lipids, mitigating the  development of dyslipidemia and hepatic steatosis (fatty liver) when animals are fed high-fat and high- cholesterol diets. To investigate the potential of adult  zebrafish for atherosclerosis, a 10-month feeding  experiment using a control diet and a high cholesterol   diet was conducted with wild-type (WIK strain), XR knock -out (nr1h3z101a/z102a), and intestinal LXR-over-expressing animals (Tg(fabp2:EGFP-nr1h3)z103). Here we found that when fed a high-cholesterol diet, nr1h3z101 a/z102 a mutants exhibited higher plasma cholesterol levels and higher levels of cholesterol and cholesteryl esters in the liver. Tg(fabp2:EGFP-nr1h3)z103 animals were protected from this steatosis. This suggests that  enterocyte-limited LXR activation prevents transport  and delivery of cholesterol to other organs. To understand  the transport of lipid absorption and to examine intravascular lipid metabolism using live imaging, an experiment was performed using 6 days post-fertilization larvae. When Tg(fabp2:EGFP-nr1h3)z103, nr1h3z101a/z102a and WIK larvae were fed with a solution of triolein (a triglyceride), cholesteryl oleate(a  cholesteryl ester), and the cholesteryl ester conjugate  to the fluorescent fatty acid analog BODIPY-undecanoate (CE11-BODIPY; a fluorescent molecule to track lipids), we found that intestinal over-expression of LXR delayed the appearance of fluorescent lipids in the  vasculature. Understanding how LXR regulates handling  of intestinal  lipids provides an important step  toward developing new therapies to treat  therosclerosis  while  avoiding lipid production in the liver.
Tariqilabeo adiscus
Creators: name: Jouladeh-Roudbar, Arash
name: Ghanavi, Hamid Reza
name: Doadrio, Ignacio
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Cypriniformes
Cyprinidae
Tariqilabeo
Tariqilabeo adiscus

description: Tariqilabeo adiscus (Annandale, 1919) – Native
(Fig. 166)
 Discognathus adiscus Annandale [N.] 1919: 68; Type locality: Seistan, eastern Iran. Holotype: ZSI F9763/1. Paratypes: BMNH 1919.8.16.7–8 [ex ZSI] (2), ZIN 25411 (3), ZSI F9758/1 (20).
 Common name: Pr: Sanglise Sistani, En: Sistan Latia.
 Diagnosis: Usualy two pairs of long barbels, 19– 22 gill rakers, 3–5 usually 4 scales between anus and anal fin.
 Meristic characters: D: III 8–9 (8), A: II–III (III) 4–5 (5), P: 14–15, V: 9–10, GR: 19–22, LL: 34–38, TV: 35–36.
 Distribution: Sistan basin (Fig. 167). Found in Hirmand River and Chahnime Lakes.
 Taxonomy: Coad (1996) placed in Crossochelus, Sayyadzadeh et al. (2015a) placed in Gonorhynchus but Kottelat (2016) transferred to Tariqilabeo.
 Conservation: IUCN: Not Evaluated, PC: Least Concern. Populations of this species are widespread and no major thread seems to affect its populations. Therefore, we classified it as Least Concern.
description: Published as part of Jouladeh-Roudbar, Arash, Ghanavi, Hamid Reza & Doadrio, Ignacio, 2020, Fig. 4 in Fig. 4 in Fig. 3 in Fig. 21. Sesarmops mora n in Paralbunea dayriti, pp. 1-303 in Zoological Studies 59 (21) on page 94, DOI: 10.6620/ZS.2020.59-21, http://zenodo.org/record/12822787
Signaling Role of the Hamp Domain in the Escherichia Coli Serine Chemoreceptor
Creators: name: Hunter, Samuel
Publisher: name: University of Utah
Year: 2016
Subjects: Chemoreceptors - Research

description: The chemoreceptor Tsr enables Escherichia coli to track   serine gradients in its environment. Binding of serine to the periplasmic domain propagates a signaling conformational change  through other domains of  the   chemoreceptor molecule to modulate the activity of CheA, a kinase associated with the cytoplasmic tip of Tsr. Changes in CheA activity influence the rotational behavior of the cell's flagellar motors. My work focused on two Tsr domains involved in CheA control; the TM2 transmembrane helix connects the periplasmic serine-binding domain to the cytoplasmic kinase control domain, and influences the packing stability of the adjoining HAMP domain via a five- residue control cable. The HAMP domain relays input signals to the kinase control domain; E248, a HAMP domain residue, is critical for the function of the HAMP domain. To analyze the role of E248 in HAMP domain function, I constructed and characterized mutant chemoreceptors with various amino acid replacements at this residue. The  E248 alterations abrogated function of the chemoreceptor, either by locking it in the "kinase- off" (E248A, E248G, E248S, E248W) or the "kinase-on" (E248R, E248Q) output state. These results suggest that E248 may be optimal for intermediate stability of the HAMP domain.  I also constructed mutant chemoreceptors with one-residue amino acid insertions at various locations within the TM2 domain to assess its structural interactions with the control cable and the HAMP domain. TM2 insertions shifted Tsr output towards the "kinase-on" state, whereas insertions within the control cable generally shifted the chemoreceptor towards the "kinase-off" state. These results suggested a helix-clutch mechanism for transmembrane siglnaling by the Tsr chemoreceptor.
Schwerzenbach
Creators: name: Keller, Heinrich
Publisher: name: [s.n.]
Year: 1813
Subjects: Kirchenbau

description: Skizzenhafte Ansicht der 1812-1813 nach Plänen von Hans Conrad Bluntschi errichteten Ovalkirche, allerdings ohne die markanten Rundungen des Ovals, vor dem Bau der Treppenanlange 1817
description: Auf einer Seite in einem Album mit elf weiteren eingeklebten Zeichnungen
description: Das Album hat 73 paginierte Seiten mit 372 eingeklebten Zeichnungen (nach heutiger Zählung 343), seine Entstehungszeit ist unbekannt
Electing representative representatives: a case for modified single transferable voting in American legislative elections
Creators: name: Gordon, Oakley Benedict
Publisher: name: University of Utah
Year: 2016
Subjects: American government
Voting - United States

description: American government is founded upon the principle that its rulers should represent and be elected by its citizenry. To this end, America and its states elect large deliberative bodies charged with representing the people within their jurisdictions. The architects of federal and state governments, however, have struggled to create a voting system that elects legislative bodies which accurately represent their electorates. This paper first examines the successes and failures to create such a system in America. Most importantly, it proposes that adopting three-member districts and a modified version of single transferable voting would be the best system with which to elect members of Congress and the state legislatures. These changes would create competitive elections that would be more sensitive and reflective of the will of the electorate.
พิธีกรรมพื้นบ้านล้านนา มิติการสร้างเสริมสุขภาพจิต
Creators: name: สามารถ  ใจเตี้ย
Publisher: name: กองนวัตกรรมและวิจัย กรมควบคุมโรค
Year: 2563
Subjects: พิธีกรรมพื้นบ้านล้านนา
การสร้างเสริมสุขภาพ
สุขภาพจิต

description: วารสารควบคุมโรค, 46, 3, 219-229
Cabdio morar
Creators: name: Jouladeh-Roudbar, Arash
name: Ghanavi, Hamid Reza
name: Doadrio, Ignacio
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Cypriniformes
Cyprinidae
Cabdio
Cabdio morar

description: Cabdio morar (Hamilton, 1822) – Native  (Fig. 172)
 Cyprinus morar Hamilton [F.] 1822: 264, 384; Type locality: Yamuna and Tista Rivers, India. No types known.
 Aspidoparia sardina Heckel [J. J.] 1847: 288; Type locality: Assam, India. No types known.
 Common name: Pr: Waspi, En: Common Chilwa.
 Diagnosis: A distinctive and large suborbital ring, which is being almost as deep as the eye and small ventral mouth.
 Meristic characters: D: II–III 6–7 (7), A: II 8–9 (9), P: 9–14, V: 7, GR: 17–25, LL: 36–45, TV: 36–37.
 Distribution: Makran and Mashkid basins (Fig. 173). Found in Mashkid, Sarbaz and Jegin Rivers.
 Taxonomy: Shrestha (1978) placed in Aspidoparia but Liao et al. (2011) transferred this species in Cabdio.
 Conservation: IUCN: Least Concern (Chaudhry 2010a).
description: Published as part of Jouladeh-Roudbar, Arash, Ghanavi, Hamid Reza & Doadrio, Ignacio, 2020, Fig. 4 in Fig. 4 in Fig. 3 in Fig. 21. Sesarmops mora n in Paralbunea dayriti, pp. 1-303 in Zoological Studies 59 (21) on pages 96-97, DOI: 10.6620/ZS.2020.59-21, http://zenodo.org/record/12822787
Whartonia brevis Domrow 1962
Creators: name: Stekolnikov, Alexandr A.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Trombiculidae
Whartonia
Whartonia brevis

description: Whartonia brevis Domrow, 1962
Whartonia brevis Domrow, 1962c: 5, figs. 10–15.
Whartonia (Asolentria) brevis: Vercammen-Grandjean 1968: 126.
Type deposition. USNM.
Type data. Ex bat, Laos, Xieng Khouang Province, in caves near the aerodrome.
Hosts. CHIROPTERA: Chiroptera gen. sp.
Distribution. Laos.
description: Published as part of Stekolnikov, Alexandr A., 2021, A checklist of chigger mites (Acariformes: Trombiculidae) of Southeast Asia, pp. 1-163 in Zootaxa 4913 (1) on page 50, DOI: 10.11646/zootaxa.4913.1.1, http://zenodo.org/record/4448915
Les  maisons ruinées a Seglingen
Creators: name: Keller, Heinrich
Publisher: name: [s.n.]
Year: 1799
Subjects: Kriegszerstörung
Ruine

description: Gezeigt wird das 1799 zerstörte Seglingen (heute: Teil der Gemeinde Eglisau), das beim Einmarsch der Franzosen zum Kriegsschauplatz wurde
description: Auf einer Seite in einem Album mit einer weiteren eingeklebten Zeichnung
description: Das Album hat 73 paginierte Seiten mit 372 eingeklebten Zeichnungen (nach heutiger Zählung 343), seine Entstehungszeit ist unbekannt
Searching for x(3872) on the lattice
Creators: name: Lee, Song-haeng
Publisher: name: University of Utah
Year: 2016
Subjects: charmonium
Lattice QCD
Particle physics
Quantum Chromodynamics
variational method
X3872

description: The purpose of this dissertation is to provide high-precision lattice quantum chromodynamics (QCD) simulation results for the mass splittings of low-lying charmonium states as the test of the Standard Model, and, further, to study the nature of a higher mass charmonium-like state called X(3872). Since the discovery of charmonium, it has played an important role in the study of QCD. However, it had been impossible to study charmonium energy levels at a low energy regime in QCD perturbative theory due to color connement, which is the consequence of the SU(3) nonabelian gauge theory in QCD. From this point of view, numerical simulation with lattice QCD is a unique method that provides a nonperturbative, ab initio approach for studying hadronic states governed by the strong interactions. In this dissertation, I describe a high-precision study of the splittings of the low-lying charmonium states, particularly the 1S and 1P states, including a chiral-continuum extrapolation. The highly excited charmonium states, discovered in the past decade, are much more challenging to study because their energy levels lie near or above the D^0 D^0 threshold, so they cannot be explained within the conventional quark model. Among those, we are interested in the narrow charmonium-like state, X(3872), due to its closeness to the DD* threshold and its possible four-quark nature. Since the X(3872) mass is within 1 MeV of the DD* threshold, it is a strong candidate for a DD* molecular state. Therefore, we use interpolating operators including both the conventional, excited P-wave charmonium state, Xc1, and the DD* open charm state for the isospin 0 channel. I provide the theoretical background for the lattice calculation and the corresponding methodologies, report on our high-precision results for the mass splittings of low-lying charmonium states, I introduce a new methodology called the \staggered variational method"", which is a variational method applied to the staggered fermion formalism, and nally, I present the simulation results for the X(3872) with quantum numbers J^{PC} = 1^{++} and isospin 0, using lattice QCD, as well as the detailed analysis and our  interpretation to reveal the physical nature of X(3872).
Gegen Seglingen bey Eglisau
Creators: name: Keller, Heinrich
Publisher: name: [s.n.]
Year: 1795

description: Der Hiltenberg, Strasse gegen Bülach, Feld gegen Tössrieden, Weg nach Tössrieden
description: Auf einer Seite in einem Album mit einer weiteren eingeklebten Zeichnung
description: Das Album hat 73 paginierte Seiten mit 372 eingeklebten Zeichnungen (nach heutiger Zählung 343), seine Entstehungszeit ist unbekannt
description: Auf dem Unterlageblatt rechts oben nummeriert: "23"
Klungeri Kasten bei'm Sihlsprung
Creators: name: Keller, Heinrich
Publisher: name: [s.n.]
Year: 1795
Subjects: Schlucht

description: Felsformation mit darauf kletternden und stehenden Menschen
description: Auf einer Seite in einem Album eingeklebt
description: Das Album hat 73 paginierte Seiten mit 372 eingeklebten Zeichnungen (nach heutiger Zählung 343), seine Entstehungszeit ist unbekannt
description: Vergleiche eine weitere Zeichnung desselben Motivs, Signatur: ZH, Hirzel I, 2
Required data for paper publication.
Creators: name: Chen, Yufeng
name: Deng, Bing
name: Zhang, Weiguo
name: Zhang, Guiling
Publisher: name: figshare
Year: 2022
Subjects: subject: 40305 Marine Geoscience
subject: FOS: Earth and related environmental sciences
subject: Geology
subject: Geophysics
subject: 40310 Sedimentology

description: Those uploaded files are required data for the manuscript "Response of shallow gas-charged Holocene deposits in the Yangtze Delta to meter-scale erosion induced by diminished sediment supply: Increasing greenhouse gas emissions" submitted to JGR: Earth Surface.
Seebach
Creators: name: Keller, Heinrich
Publisher: name: [s.n.]
Year: 1795
Subjects: Kirchenbau

description: Alte Reformierte Kirche Seebach
description: Auf einer Seite in einem Album mit acht weiteren eingeklebten Zeichnungen
description: Das Album hat 73 paginierte Seiten mit 372 eingeklebten Zeichnungen (nach heutiger Zählung 343), seine Entstehungszeit ist unbekannt
Whartonia caobangensis Schluger, Grochovskaja, Ngu, Hoe and Tung 1959
Creators: name: Stekolnikov, Alexandr A.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Trombiculidae
Whartonia
Whartonia caobangensis

description: Whartonia caobangensis Schluger, Grochovskaja, Ngu, Hoe and Tung, 1959
Whartonia caobangensis Schluger, Grochovskaja, Ngu, Hoe and Tung, 1959: 422, fig. 3; Domrow 1962c: 1; Wen 1984b: 325; Kudryashova 2004: 12; Chau et al. 2007: 188, fig. 94; Ahamad et al. 2013: 140.
Whartonia (Asolentria) caobangensis: Vercammen-Grandjean 1968b: 126.
Whartonia recurvata Chen and Hsu, 1959: 549, figs. 1–10.
Type deposition. W. caobangensis: ZMMU Tdt 3175 (syntypes); W. recurvata: ZSM.
Type data. W. caobangensis: Ex Hipposideros armiger, North Vietnam; W. recurvata: ex Pipistrellus pipistrellus and Hipposideros larvatus poutensis (syn. Hipposideros poutensis), China, Kwangtung (Guangdong) Province, Mapa, Kukong.
Hosts. CHIROPTERA: Hipposideros armiger, H. bicolor, H. cervinus, H. diadema, H. larvatus, H. larvatus poutensis, Kerivoula hardwickii, Pipistrellus pipistrellus, Rhinolophus affinis.
Distribution. China, Indonesia, Malaysia, Vietnam.
Remarks. Whartonia recurvata was synonymized with W. caobangensis by Domrow (1962c), but Vercammen-Grandjean (1968) listed the former as a separate species.
description: Published as part of Stekolnikov, Alexandr A., 2021, A checklist of chigger mites (Acariformes: Trombiculidae) of Southeast Asia, pp. 1-163 in Zootaxa 4913 (1) on page 51, DOI: 10.11646/zootaxa.4913.1.1, http://zenodo.org/record/4448915
Required data for paper publication.
Creators: name: Chen, Yufeng
name: Deng, Bing
name: Zhang, Guiling
Publisher: name: figshare
Year: 2022
Subjects: subject: 40305 Marine Geoscience
subject: FOS: Earth and related environmental sciences
subject: Geology
subject: Geophysics
subject: 40310 Sedimentology

description: Those uploaded files are required data for the manuscript "Response of shallow gas-charged Holocene deposits in the Yangtze Delta to meter-scale erosion induced by diminished sediment supply: Increasing greenhouse gas emissions" submitted to JGR: Earth Surface.
title: PROTEOMIC AND METABOLOMIC SIGNATURES OF ARTHROPATHIES
Creators: name: Anderson, JR
Publisher: name: University of Liverpool Repository
Year: 2019

description: Osteoarthritis (OA) and rheumatoid arthritis (RA) are the most common arthropathies in people, causing limited mobility, pain and subsequent reduction in quality of life, resulting in a substantial impact on human society. Conditions affecting articular joints are also common in horses, including OA, osteochondrosis (OC) and synovial sepsis. Despite their high prevalence and clinical relevance, diagnosis, staging, monitoring and determining an accurate prognosis remain a challenge. Thus, there is a need to identify reliable biomarkers of disease. The development of ‘omics’ technologies, such as metabolomics and proteomics, has provided global analysis of biological tissues and fluids, enabling discovery of disease biomarkers and providing a greater understanding of their underlying pathogeneses. Within this thesis, protocols for collection and processing of synovial fluid (SF) for nuclear magnetic resonance (NMR) metabolomic and liquid chromatography-tandem mass spectrometry (LC-MS/MS) proteomic analysis have been optimised. Lys-C endopeptidase pre-digestion greatly improved on-bead tryptic SF protein digestion when used in conjunction with randomised hexapeptide ProteoMiner™ beads for low abundant protein enrichment. Equine OA was stratified using metabolomic and proteomic SF profiles, identifying a panel of markers which may be applicable to grading OA severity. This is the first study to undertake computational integration of NMR metabolomic and LC-MS/MS proteomic datasets of any biological system. This thesis is also the first study to use a multi ‘omics’ approach to simultaneously investigate the metabolomic profile of ex-vivo cartilage and metabolomic/proteomic profiles of culture media using the TNF-α/IL-1β ex-vivo cartilage OA model. A panel of metabolites, proteins and neopeptides were identified which were differentially abundant within an early phase of this OA model and may provide further information on the underlying disease pathogenesis. Comparing human OA and RA SF identified that the metabolic pathways that differed most were glycolysis, amino acid biosynthesis and taurine and hypotaurine metabolism. This thesis has also identified a panel of metabolites and proteins within equine SF which can distinguish synovial sepsis from nonseptic joint pathologies, with glucose the principal metabolite discriminator.
Development of Pathway-Based Biomarker in Breast Cancer and Assessment of Feasibility of Integrating Transcriptomics Data in Electronic Health Record
Creators: name: Rahman, Mumtahena
Publisher: name: University of Utah
Year: 2016

description: Despite the advancements in therapies, next-generation sequencing, and our knowledge, breast cancer is claiming hundreds of thousands of lives around the world every year. We have therapy options that work for only a fraction of the population due to the heterogeneity of the disease. It is still overwhelmingly challenging to match a patient with the appropriate available therapy for the optimal outcome. This dissertation work focuses on using biomedical informatics approaches to development of pathwaybased biomarkers to predict personalized drug response in breast cancer and assessment of feasibility integrating such biomarkers in current electronic health records to better implement genomics-based personalized medicine. The uncontrolled proliferation in breast cancer is frequently driven by HER2/PI3K/AKT/mTOR pathway. In this pathway, the AKT node plays an important role in controlling the signal transduction. In normal breast cells, the proliferation of cells is tightly maintained at a stable rate via AKT. However, in cancer, the balance is disrupted by amplification of the upstream growth factor receptors (GFR) such as HER2, IGF1R and/or deleterious mutations in PTEN, PI3KCA. Overexpression of AKT leads to increased proliferation and decreased apoptosis and autophagy, leading to cancer. Often these known amplifications and the mutation status associated with the disease progression are used as biomarkers for determining targeting therapies. However, downstream known or unknown mutations and activations in the pathways, crosstalk iv between the pathways, can make the targeted therapies ineffective. For example, one third of HER2 amplified breast cancer patients do not respond to HER2-targeting therapies such as trastuzumab, possibly due to downstream PTEN loss of mutation or PIK3CA mutations. To identify pathway aberration with better sensitivity and specificity, I first developed gene-expression-based pathway biomarkers that can identify the deregulation status of the pathway activation status in the sample of interest. Second, I developed drug response prediction models primarily based on the pathway activity, breast cancer subtype, proteomics and mutation data. Third, I assessed the feasibility of including gene expression data or transcriptomics data in current electronic health record so that we can implement such biomarkers in routine clinical care.
A genetic analysis of VSX2 function in the mouse eye
Creators: name: German, Massiell
Publisher: name: University of Utah
Year: 2016
Subjects: Neurogenesis - physiology

description: Vsx2 is a homeodomain-containing transcription factor essential for maintenance of neuroretinal identity and neurogenesis. Vsx2 is believed to function via mechanisms that are strictly cell-intrinsic. However, recent research reveals evidence for involvement of Vsx2-mediated cell non-autonomous mechanisms. This leads to the hypothesis that Vsx2 regulates cell non-autonomous pathways that play a role in maintaining neuroretinal identity and neurogenesis. To test this hypothesis, genetic chimeras were generated by morula aggregations of transgenic ActB:EYFP transgenic mice homozygous for wild type alleles of Vsx2 [Tg(EYFP/EYFP);Vsx2] and mice that are homozygous for null alleles of Vsx2 (Vsx2orj/orj). Maintenance of neuroretinal identity is assessed by immunostaining for the expression of MITF, a retinal pigmented epithelium (RPE) gene that regulates many pigmentation pathway genes. Neurogenesis is assessed through analysis of cell differentiation using immunostaining for several cell-type specific markers. Analysis of the retinas of tg(EYFP/EYFP);Vsx2 ↔ Vsx2orj/orj chimeras reveals the presence of MITF expression in Vsx2orJ/orJ cells but not Vsx2+/+ cells indicating that neighboring Vsx2+/+ cells are unable to rescue Vsx2orJ/orJ cells from loss of neuroretinal identity. Analysis also reveals that Vsx2orJ/orJ cell differentiation remains delayed indicating that neighboring Vsx2+/+ cells are unable to rescue Vsx2orJ/orJ cells from delayed neurogenesis. These findings suggest that Vsx2 regulates neuroretinal identity and neurogenesis by cell-autonomous mechanisms.
Seegreben
Creators: name: Keller, Heinrich
Publisher: name: [s.n.]
Year: 1795
Subjects: Kirchenbau

description: Reformierte Kirche Seegräben
description: Auf einer Seite in einem Album mit acht weiteren eingeklebten Zeichnungen
description: Das Album hat 73 paginierte Seiten mit 372 eingeklebten Zeichnungen (nach heutiger Zählung 343), seine Entstehungszeit ist unbekannt
Impacts of Tobacco Smoke Exposure and Outlier Body Mass  Indices on Pediatric Asthma Outcomes
Creators: name: Black, Taylor Madison
Publisher: name: University of Utah
Year: 2016
Subjects: Asthma - Child
Tobacco smoke - Health aspects - United States

description: There are seven million children in the United States impacted by asthma [1]. When assessing the severity of a child's asthma, it is important to take into account risk  factors known to affect child hood asthma. Two such risk factors that are modifiable include parental tobacco smoke exposure (TSE) and body mass indices (BMI).  The main objective of this study was to determine how patients with both TSE and outlier BMIs (>90% or <10%) compared to the whole study population. In particular,  three main outcomes were examined: cost of hospitalization, length of stay, and severity of illness. It was determined that TSE and outlier BMI correlated with increased hospitalization length (p=0.05). However, severity of illness (p=0.09) and cost of hospitalization (p=0.1) were not significant. Further studies need to be conducted in order to determine if other pediatric asthma outcomes could change for TSE and outlier BMI patients.
Seegræben
Creators: name: Keller, Heinrich
Publisher: name: [s.n.]
Year: 1795
Subjects: Kirchenbau

description: Reformierte Kirche Seegräben
description: Auf einer Seite in einem Album mit acht weiteren eingeklebten Zeichnungen
description: Das Album hat 73 paginierte Seiten mit 372 eingeklebten Zeichnungen (nach heutiger Zählung 343), seine Entstehungszeit ist unbekannt
Plant architecture and the allometry of hydraulic transport, light interception and growth
Creators: name: Smith, Duncan D.
Publisher: name: University of Utah
Year: 2016
Subjects: hydraulic conductance
light interception
Metabolic Scaling Theory
modeling
optimization
vascular architecture

description: The metabolic scaling theory identifies network architecture as a major predictor of whole plant metabolism via hydraulic conductance of the xylem and the shared stomatal pathway for water loss and carbon gain. To predict hydraulic properties, this theory utilizes the West, Brown, Enquist (WBE) architectural model, which is based on principles of space-filling, biomechanical stability, and optimality of hydraulic transport and it is meant to be generally representative of plants. However, plants are highly diverse in their network architecture. Does this diversity matter or does it represent different ways of accomplishing the same task? This dissertation addresses that question by extending WBE to include architectural variation and by testing model predictions and assumptions.  The model predicts the scaling exponent between hydraulic conductance and plant size. This exponent depends on the ""bottleneck"" effect, where greater hydraulic resistance in leaves and twigs steepens the exponent. The bottleneck effect was greater when xylem conduits were much larger or more abundant in the trunk than in the twigs. Observed diversity in xylem properties predicted that different functional groups had substantial overlap in hydraulic transport and its scaling. Branching architecture did not influence the bottleneck effect. However, deviating from WBE increased hydraulic conductance and biomechanical stability while requiring less tissue but reducing light interception. Branching could alter hydraulic scaling if architecture changed ontogenetically, which data suggested.  MST assumes direct proportionality between sap flow and growth. This was supported in five of six tested species. However, tree species grew more per water use than shrubs, likely reflecting differential allocation. Differences between species were partially attributable to xylem anatomy and plant size.  Among this variation in xylem anatomy, branching architecture, and plant stature, the dimensions of leaves and twigs also vary with thicker twigs curiously tending to support few large leaves instead of many small leaves (Corner's rule). Why do plants coordinate leaf and twig size? Corner's rule was recast as the prediction that larger twig leaf areas are composed of larger leaves. Species supported this prediction and had highly convergent scaling. A model predicted that Corner's rule exists to optimize the return on investment in leaves.
Ash deposition and ash aerosol formation mechanisms during oxy-coal combustion
Creators: name: Zhan, Zhonghua
Publisher: name: University of Utah
Year: 2016
Subjects: aerosol
ash
combustion
deposition
oxy-coal
recycle

description: Oxy-coal combustion has been considered a promising technology for CO2 capture for existing coal-fired power plants. This work is concerned with the effects of retrofit on both the fly ash and the deposits. The research targets include: 1) To find out the difference between ash aerosol and ash deposit formation between oxy-coal combustion and air combustion. 2) To ascertain the relationships between deposits composition and size segregated ash aerosol composition. 3) To find out ash aerosol and ash deposit formation characteristics during oxy-coal combustion under various recycled flue gas (RFG) cleanup options and various RFG amounts. 4) To build up a model to predict ash deposition rate on a vertical surface. Ash aerosol and ash deposits formation during oxy-coal combustion were explored through experiments in a self-sustained 100 kW rated down-fired oxy-fuel combustor, firing a Powder River Basin coal. The results showed that it was necessary to treat the deposits separately (inside, outside, vertical and side) other than in bulk, because the deposits from different locations of the probe showed different characteristics in both composition and particle size distribution. Deposits from the vertical and side surfaces were more similar to the inside deposits than to the bulk deposits. The main formation mechanism for vertical (inside) deposits was transportation of the vaporization mode ash aerosols through thermophoresis. Cases of oxy-coal combustion under various RFG cleanup options and various RFG amounts were also conducted to identify ash aerosols and ash deposit formation characteristics. The results showed that the extent of RFG cleanup options had little effect on the ash aerosol compositions or size distributions. However, OXY50 cases produced more vaporization mode particles due to higher combustion temperature. Finally, a model was built up to predict ash deposition rate on a vertical surface within a laminar flow field. A dimensionless number, Thermophoresis number (Tp), was defined, which was the ratio of travel time by thermophoresis force and travel time by drag force. The criterion that a particle would be captured onto the vertical surface was Tp < 1. The predicted ash deposition rates showed high consistence with the experimental data.
The economic effects of legalizing marijuana
Creators: name: Glauser, David
Publisher: name: University of Utah
Year: 2016
Subjects: Marijuana - Political aspects - United States

description: Marijuana legalization would offer an important advantage over decriminalization in that it would allow for legal distribution and taxation of cannabis as well as decrease costly enforcement and incarceration expenses. Despite these costly enforcement efforts, marijuana is the most commonly used illicit drug in America. According to a survey done in 2008 by the National Institute of Drug Abuse, 42% of 12th graders in the United States have used marijuana at some point in their life. High demands for marijuana likely indicate that legalization of the drug would have an enormous effect on the American economy. In a time of economic recession and government debt of record proportions, it is extremely beneficial to look into the possible advantages and disadvantages of such legislation. By comparing different studies done by various organizations and departments as well as analyzing areas that have already legalized marijuana, such as the Netherlands, I was able to determine approximately how the economy would be affected on several different issues. Some figures that would be affected are: employment, the demand for marijuana, taxation rates and potential government revenue, incarceration and enforcement costs, and social issues such as rehabilitation programs. According to my research, the United States government would experience an increase of $25,963,686,520 towards their budget.
Biofuel cells for self powered arsenic detection
Creators: name: Rose, Steven
Publisher: name: University of Utah
Year: 2016
Subjects: Fuel cells
Arsenic - Detection

description: Research in the Minteer group has centered on procedures for immobilizing enzymes and organelles on carbon electrodes for use in sensory and fuel cell applications. Similar strategies have been used to prepare a series of electrodes capable of pyruvate oxidation which, in the presence of arsenic, will be inhibited. These electrodes, when incorporated into a biofiiel cell, will show decreased power output in the presence of arsenic compounds. This inhibition and corresponding power decrease will make it possible to sense the presence of arsenic, allowing for the self-powered detection of it. For the electrodes, three types of bioelectrocatalysts are to be examined: enzymes, mitochondria, and whole cells. This will enable sensitivity and specificity comparisons between the electrode types. Whole-cell electrodes utilizing yeast as a catalyst have been designed and are currently being tested for arsenic sensitivity. Poly-L-lysine immobilization has proven effective for immobilizing yeast onto an electrode while maintaining functionality of the yeast.
Tariqilabeo diplocheilus
Creators: name: Jouladeh-Roudbar, Arash
name: Ghanavi, Hamid Reza
name: Doadrio, Ignacio
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Cypriniformes
Cyprinidae
Tariqilabeo
Tariqilabeo diplocheilus

description: Tariqilabeo diplocheilus (McClelland, 1839) – Native  (Fig. 168)
 Barbus diplochilus Heckel [J. J.] 1838: 53; Type locality: Kashmir. Syntypes: NMW 48820 (7).
 Tylognathus barbatulus Heckel [J. J.] 1844: 376; Type locality: Kashmir. Syntypes: NMW 48820 (6).
 Crossochilus latius punjabensis Mukerji [D. D.] 1934: 53; Type locality: Katas, Nallah, Salt Range and Khewra Gorge, Punjab, Pakistan, elevation about 2,000 feet. Syntypes: whereabouts unknown.
 Common name: Pr: Sanglise Keshmir, En: Kashmir Latia.
 Diagnosis: Almost one pairs of short barbels, 22–25 gill rakers, 2–3 scales between anus and anal fin.
 Meristic characters: D: III 8, A: II–III (III) 4–5 (5), P: 16, V: 9–10, GR: 22–25, LL: 34–38, TV: 35–36.
 Distribution: Makran and Mashkid basins (Fig. 169). Found in Sirkan and Sarbaz rivers.
 Taxonomy: Bianco and Bǎnǎrescu (1982) placed as a subspecies of diplochilus, Kullander et al. (1999) valid as Crossocheilus diplochilus, Sayyadzadeh et al. (2015a) placed in Gonorhynchus but Kottelat (2016) transferred to Tariqilabeo.
 Conservation: IUCN: Least Concern (under name Crossocheilus latius (Singh 2010)).
description: Published as part of Jouladeh-Roudbar, Arash, Ghanavi, Hamid Reza & Doadrio, Ignacio, 2020, Fig. 4 in Fig. 4 in Fig. 3 in Fig. 21. Sesarmops mora n in Paralbunea dayriti, pp. 1-303 in Zoological Studies 59 (21) on page 95, DOI: 10.6620/ZS.2020.59-21, http://zenodo.org/record/12822787
Whartonia dewitti Nadchatram 1980
Creators: name: Stekolnikov, Alexandr A.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Trombiculidae
Whartonia
Whartonia dewitti

description: Whartonia dewitti Nadchatram, 1980
Whartonia dewitti Nadchatram, 1980: 324, figs. 1–7; Chaisiri et al. 2016: 337.
Type deposition. IMR.
Type data. Ex Rhinolophus affinis, Malaysia, Perak State, Sungei Siput.
Hosts. CHIROPTERA: Rhinolophus affinis.
Distribution. Malaysia, Thailand.
description: Published as part of Stekolnikov, Alexandr A., 2021, A checklist of chigger mites (Acariformes: Trombiculidae) of Southeast Asia, pp. 1-163 in Zootaxa 4913 (1) on page 51, DOI: 10.11646/zootaxa.4913.1.1, http://zenodo.org/record/4448915
Additional file 1 of Interferon-beta enhances sensitivity to gemcitabine in pancreatic cancer
Creators: name: Blaauboer, Amber
name: Booy, Stephanie
name: Koetsveld, Peter M. Van
name: Karels, Bas
name: Dogan, Fadime
name: Zwienen, Suzanne Van
name: Eijck, Casper H. J. Van
name: Hofland, Leo J.
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1 Figure S1. Dose response curves of gemcitabine (A) and interferon-bèta (B) on total DNA amount, as a measure of cell number, in ● BxPC-3, ■ CFPAC-1, and ▲ Panc-1 after 3 days of treatment. Figure S2. Effect of interferon-bѐta (IFN-β) pre-treatment on gemcitabine response in BxPC-3 (left panel), CFPAC-1 (middle panel), and Panc-1 (right panel). Figure S3. Effect of interferon-bѐta (IFN-β) on gemcitabine response in BxPC-3 (left panel), CFPAC-1 (middle panel), and Panc-1 (right panel). Figure S4. Baseline mRNA expression of genes involved in gemcitabine transport and metabolism in BxPC-3 (light grey bar), CFPAC-1 (dark grey bar), and Panc-1 (black bar). Table S1. Primers and probes used for real time quantitative PCR.