cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Refining Business Processes
Creators: name: Rumpe, Bernhard
name: Thurner, V.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: In this paper we present a calculus for re nement of business process models based on a precisede nition of business processes and process nets Business process models are a vital concept for communicating with experts of the application domain Depending on the roles and responsibilities of the application domain experts involved process models are discussed on different levels of abstraction These may range from detailed regulations for process execution to the interrelation of basic core processes on a strategic level To ensure consistency and to allow for a exible integration of process information on di erent levels of abstraction we introduce re nement rules that allow the incremental addition to and re nement of the information in a process model while maintaining the validity of more abstract high level processes In particular we allow the decomposition of single processes and logical data channels as well as the extension of the interface and channel structure to information that is newly gained or increased in relevance during the modeling process.
description: 16 pages, 10 figures
Community Participation in the Prevention of Children and Youth Violence on Heet Look –Kong Hlan of Isan Culture in Mahasarakham Province
Creators: name: Panya Senawiang
Publisher: name: DR.KEN Institute of Academic Development and Promotion
Year: 2022
Subjects: Community Participation
Problem of Violence Among Children and Youth
Heet Look –Kong Hlan of Isan Culture

description: Interdisciplinary Academic and Research Journal, 2, 6, 253-268
Healthspan Enhancement by Olive Polyphenols in C. elegans Wild Type and Parkinson’s Models
Creators: name: Di Rosa, Gabriele
name: Brunetti, Giovanni
name: Scuto, Maria
name: Trovato Salinaro, Angela
name: Calabrese, Edward J.
name: Crea, Roberto
name: Schmitz-Linneweber, Christian
name: Calabrese, Vittorio
name: Saul, Nadine
Publisher: name: Humboldt-Universität zu Berlin
Year: 2020
Subjects: subject: C. elegans
subject: polyphenols
subject: olive oil
subject: healthspan
subject: lifespan
subject: ageing
subject: Parkinson's disease
subject: 570 Biologie
subject: 610 Medizin und Gesundheit

description: Parkinson’s disease (PD) is the second most prevalent late-age onset neurodegenerative disorder, affecting 1% of the population after the age of about 60 years old and 4% of those over 80 years old, causing motor impairments and cognitive dysfunction. Increasing evidence indicates that Mediterranean diet (MD) exerts beneficial effects in maintaining health, especially during ageing and by the prevention of neurodegenerative disorders. In this regard, olive oil and its biophenolic constituents like hydroxytyrosol (HT) have received growing attention in the past years. Thus, in the current study we test the health-promoting effects of two hydroxytyrosol preparations, pure HT and Hidrox® (HD), which is hydroxytyrosol in its “natural” environment, in the established invertebrate model organism Caenorhabditis elegans. HD exposure led to much stronger beneficial locomotion effects in wild type worms compared to HT in the same concentration. Consistent to this finding, in OW13 worms, a PD-model characterized by α-synuclein expression in muscles, HD exhibited a significant higher effect on α-synuclein accumulation and swim performance than HT, an effect partly confirmed also in swim assays with the UA44 strain, which features α-synuclein expression in DA-neurons. Interestingly, beneficial effects of HD and HT treatment with similar strength were detected in the lifespan and autofluorescence of wild-type nematodes, in the neuronal health of UA44 worms as well as in the locomotion of rotenone-induced PD-model. Thus, the hypothesis that HD features higher healthspan-promoting abilities than HT was at least partly confirmed. Our study demonstrates that HD polyphenolic extract treatment has the potential to partly prevent or even treat ageing-related neurodegenerative diseases and ageing itself. Future investigations including mammalian models and human clinical trials are needed to uncover the full potential of these olive compounds.
A Meta-Analytic Review of Stand-Alone Interventions to Improve Body Image
Creators: name: Alleva, Jessica M.
name: Miles, Eleanor
name: Sheeran, Paschal
name: Webb, Thomas L.
name: Martijn, Carolien
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Numerous stand-alone interventions to improve body image have been developed. The present review used meta-analysis to estimate the effectiveness of such interventions, and to identify the specific change techniques that lead to improvement in body image.
Development of Role Model Ethical Leaders for the Elderly on Heet-Kong of Isan Culture in Mahasarakham Province
Creators: name: Sippiya Chayanusasanee Jundon
Publisher: name: DR.KEN Institute of Academic Development and Promotion.
Year: 2022
Subjects: Ethical Leaders
Elderly
Heet-Kong of Isan Culture

description: Interdisciplinary Academic and Research Journal, 2, 6, 269-282
SIMP J2154-1055: A New Low-Gravity L4$β$ Brown Dwarf Candidate Member of the Argus Association
Creators: name: Gagné, Jonathan
name: Lafrenière, David
name: Doyon, René
name: Artigau, Étienne
name: Malo, Lison
name: Robert, Jasmin
name: Nadeau, Daniel
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present SIMP J21543454-1055308, a new L4$β$ brown dwarf identified in the Sondage Infrarouge de Mouvement Propre (SIMP) survey that displays signs of low gravity in its near-infrared spectrum. Using the Bayesian Analysis for Nearby Young AssociatioNs II (BANYAN II), we show that it is a candidate member of the Argus association, albeit with a 21% probability that it is a contaminant from the field. Measurements of radial velocity and parallax will be needed to verify its membership. If it is a member of Argus (age 30-50 Myr), then this object would have a planetary mass of 10 $\pm$ 0.5 $M_{\mathrm{Jup}}$.
description: 5 pages, 4 figures, accepted for publication in the ApJ Letters. Minor modifications to text and references
A Method for Using Player Tracking Data in Basketball to Learn Player Skills and Predict Team Performance
Creators: name: Skinner, Brian
name: Guy, Stephen J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Player tracking data represents a revolutionary new data source for basketball analysis, in which essentially every aspect of a player’s performance is tracked and can be analyzed numerically. We suggest a way by which this data set, when coupled with a network-style model of the offense that relates players’ skills to the team’s success at running different plays, can be used to automatically learn players’ skills and predict the performance of untested 5-man lineups in a way that accounts for the interaction between players’ respective skill sets. After developing a general analysis procedure, we present as an example a specific implementation of our method using a simplified network model. While player tracking data is not yet available in the public domain, we evaluate our model using simulated data and show that player skills can be accurately inferred by a simple statistical inference scheme. Finally, we use the model to analyze games from the 2011 playoff series between the Memphis Grizzlies and the Oklahoma City Thunder and we show that, even with a very limited data set, the model can consistently describe a player’s interactions with a given lineup based only on his performance with a different lineup.
Neutrino-pair bremsstrahlung in a neutron star crust
Creators: name: Ofengeim, D. D.
name: Kaminker, A. D.
name: Yakovlev, D. G.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Based on the formalism by Kaminker et al. (Astron. Astrophys. 343 (1999) 1009) we derive an analytic approximation for neutrino-pair bremsstrahlung emissivity due to scattering of electrons by atomic nuclei in the neutron star crust of any realistic composition. The emissivity is expressed through generalized Coulomb logarithm which we fit by introducing an effective potential of electron-nucleus scattering. In addition, we study the conditions at which the neutrino bremsstrahlung in the crust is affected by strong magnetic fields. The results can be applied for modelling of many phenomena in neutron stars, such as thermal relaxation in young isolated neutron stars and in accreting neutron stars with overheated crust in soft X-ray transients.
description: 6 pages, 3 figures, EPL, accepted
A Molecular Smart Surface for Spatio-Temporal Studies of Cell Mobility
Creators: name: Chan, Eugene W. L.
name: Lee, Eun-ju
name: Luo, Wei
name: Yousaf, Muhammad N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Active migration in both healthy and malignant cells requires the integration of information derived from soluble signaling molecules with positional information gained from interactions with the extracellular matrix and with other cells. How a cell responds and moves involves complex signaling cascades that guide the directional functions of the cytoskeleton as well as the synthesis and release of proteases that facilitate movement through tissues. The biochemical events of the signaling cascades occur in a spatially and temporally coordinated manner then dynamically shape the cytoskeleton in specific subcellular regions. Therefore, cell migration and invasion involve a precise but constantly changing subcellular nano-architecture. A multidisciplinary effort that combines new surface chemistry and cell biological tools is required to understand the reorganization of cytoskeleton triggered by complex signaling during migration. Here we generate a class of model substrates that modulate the dynamic environment for a variety of cell adhesion and migration experiments. In particular, we use these dynamic substrates to probe in real-time how the interplay between the population of cells, the initial pattern geometry, ligand density, ligand affinity and integrin composition affects cell migration and growth. Whole genome microarray analysis indicates that several classes of genes ranging from signal transduction to cytoskeletal reorganization are differentially regulated depending on the nature of the surface conditions.
title: The clinical and financial efficacy of Contrast Enhanced Ultrasound in Focal Hepatic Lesion characterisation
Creators: name: Lim, Adrian K.P.
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Liver
subject: Abdomen
subject: Oncology
subject: Ultrasound
subject: CT
subject: MR
subject: Comparative studies
subject: Cost-effectiveness
subject: Contrast agent-intravenous
subject: Metastases
subject: Haemangioma
subject: Cysts

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Focal hepatic lesions (FHL) are often detected as incidental findings on cross sectional imaging. There is a wide differential diagnosis and many FHLs require further imaging for characterisation. Contrast enhanced ultrasound (CEUS) is able to...
Joint Contributions of Auditory, Proprioceptive and Visual Cues on Human Balance
Creators: name: Teaford, Max
name: J. Mularczyk, Zachary
name: Gernon, Alannah
name: Cannon, Shauntelle
name: Kobel, Megan
name: M. Merfeld, Daniel
Publisher: name: Brill Online
Year: 2023
Subjects: classificationCode: 520406
subject: Sensory processes, perception and performance

description: One’s ability to maintain their center of mass within their base of support (i.e., balance) is believed to be the result of multisensory integration. Much of the research in this literature has focused on integration of visual, vestibular, and proprioceptive cues. However, several recent studies have found evidence that auditory cues can impact balance control metrics. In the present study, we sought to better characterize the impact of auditory cues on narrow stance balance task performance with different combinations of visual stimuli (virtual and real world) and support surfaces (firm and compliant). In line with past results, we found that reducing the reliability of proprioceptive cues and visual cues yielded consistent increases in center-of-pressure (CoP) sway metrics, indicating more imbalance. Masking ambient auditory cues with broadband noise led to less consistent findings; however, when effects were observed they were substantially smaller for auditory cues than for proprioceptive and visual cues — and in the opposite direction (i.e., masking ambient auditory cues with broadband noise reduced sway in some situations). Additionally, trials that used virtual and real-world visual stimuli did not differ unless participants were standing on a surface that disrupted proprioceptive cues; disruption of proprioception led to increased CoP sway metrics in the virtual visual condition. This is the first manuscript to report the effect size of different perturbations in this context, and the first to study the impact of acoustically complex environments on balance in comparison to visual and proprioceptive contributions. Future research is needed to better characterize the impact of different acoustic environments on balance.
Magnetization reversal condition for a nanomagnet within a rotating magnetic field
Creators: name: Taniguchi, Tomohiro
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The reversal condition of magnetization in a nanomagnet under the effect of rotating magnetic field generated by a microwave is theoretically studied based on the Landau-Lifshitz-Gilbert equation. In a rotating frame, the microwave produces a dc magnetic field pointing in the reversed direction, which energetically stabilizes the reversed state. We find that the microwave simultaneously produces a torque preventing the reversal. It is pointed out that this torque leads to a jump in the reversal field with respect to the frequency. We derive the equations determining the reversal fields in both the low- and high-frequency regions from the energy balance equation. The validities of the formulas are confirmed by a comparison with the numerical simulation of the Landau-Lifshitz-Gilbert equation.
description: 9 pages, 7 figures
A Multilaboratory Comparison of Calibration Accuracy and the Performance of External References in Analytical Ultracentrifugation
Creators: name: Besong, Tabot M. D.
name: Ebel, Christine
name: Bakhtina, Marina M.
name: Becker, Donald F.
name: Eisele, Leslie E.
name: England, Patrick
name: Crowley, Kimberly A.
name: Brennerman, William
name: Bzowska, Agnieszka
name: Chaton, Catherine T.
name: Eckert, Debra M.
name: Díez, Ana I.
name: Alfonso, Carlos
name: Connaghan, Keith D.
name: Daviter, Tina
name: Bain, David L.
name: Arisaka, Fumio
name: Eisenstein, Edward
name: Cölfen, Helmut
name: Byron, Olwyn
name: Brautigam, Chad A.
name: Escalante, Carlos
name: Chaires, Jonathan B.
name: Attali, Ilan
name: Bedwell, Gregory J.
name: Dean, William L.
name: Bekdemir, Ahmet
name: Zhao, Huaying
name: Ghirlando, Rodolfo
name: Birck, Catherine
name: Fagan, Jeffrey A.
name: Curth, Ute
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Analytical ultracentrifugation (AUC) is a first principles based method to determine absolute sedimentation coefficients and buoyant molar masses of macromolecules and their complexes, reporting on their size and shape in free solution. The purpose of this multi-laboratory study was to establish the precision and accuracy of basic data dimensions in AUC and validate previously proposed calibration techniques. Three kits of AUC cell assemblies containing radial and temperature calibration tools and a bovine serum albumin (BSA) reference sample were shared among 67 laboratories, generating 129 comprehensive data sets. These allowed for an assessment of many parameters of instrument performance, including accuracy of the reported scan time after the start of centrifugation, the accuracy of the temperature calibration, and the accuracy of the radial magnification. The range of sedimentation coefficients obtained for BSA monomer in different instruments and using different optical systems was from 3.655 S to 4.949 S, with a mean and standard deviation of (4.304 ± 0.188) S (4.4%). After the combined application of correction factors derived from the external calibration references for elapsed time, scan velocity, temperature, and radial magnification, the range of s-values was reduced 7-fold with a mean of 4.325 S and a 6-fold reduced standard deviation of ± 0.030 S (0.7%). In addition, the large data set provided an opportunity to determine the instrument-to-instrument variation of the absolute radial positions reported in the scan files, the precision of photometric or refractometric signal magnitudes, and the precision of the calculated apparent molar mass of BSA monomer and the fraction of BSA dimers. These results highlight the necessity and effectiveness of independent calibration of basic AUC data dimensions for reliable quantitative studies.
Analytical formula of Free Electron Laser exponential gain for non-resonant electron beam
Creators: name: Jia, Qika
Publisher: name: arXiv
Year: 2014
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: The FEL gain formulas for non-resonant case are studied. For the mono-energetic and non-resonant electron beam, the exact expression of the solution of the FEL characteristic cubic equation is obtained with a form much more simple than that in the literatures, and the gain length as the function of the detuning parameter is explicitly given, then the gain for different detuning parameter and from low to high can be easily calculated. A simplified approximation formula is also given for the exponential gain calculation in the non-resonant case. For the case of the electron beam with an energy spread, the solution of the characteristic cubic equation is given explicitly for rectangular energy distribution and Lorentz distribution, respectively. Moreover the explicit expression also can be used for the solution of the characteristic cubic equation including the impact of the space charge. The transition from the low gain to the high gain is analyzed. The variations of the gain bandwidth and of the detuning parameter for the maximum gain are demonstrated. The applicable ranges of the small signal gain formula and the exponential gain formula are analyzed.
description: 9 pages, 8 figures
Critical phenomena in one dimension from a Bethe ansatz perspective
Creators: name: Guan, Xiwen
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: This article briefly reviews recent theoretical developments in quantum critical phenomena in one-dimensional (1D) integrable quantum gases of cold atoms. We present a discussion on quantum phase transitions, universal thermodynamics, scaling functions and correlations for a few prototypical exactly solved models, such as the Lieb-Liniger Bose gas, the spin-1 Bose gas with antiferromagnetic spin-spin interaction, the two-component interacting Fermi gas as well as spin-3/2 Fermi gases. We demonstrate that their corresponding Bethe ansatz solutions provide a precise way to understand quantum many-body physics, such as quantum criticality, Luttinger liquids, the Wilson ratio, Tan's Contact, etc. These theoretical developments give rise to a physical perspective using integrability for uncovering experimentally testable phenomena in systems of interacting bosonic and fermonic ultracold atoms confined to 1D.
description: a brief review, 21 pages, 15 figures, Eq. (9) was corrected, some new references were added in this arXiv version
Stepwise Refinement of Data Flow Architectures
Creators: name: Philipps, Jan
name: Rumpe, Bernhard
Publisher: name: arXiv
Year: 2014
Subjects: subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: This paper aims at integrating heterogeneous documents used in pragmatic software develpoment methods to describe views with a formal refinement based software development process. Therefore we propose an integrated semantics of heterogeneous documents based on a common system model and a set of syntactic development steps with a welldefined semantics for document evolution. The use of the development steps is demonstrated in a small example.
description: 18 pages, 1 figure. arXiv admin note: substantial text overlap with arXiv:1409.6932
Quantum Decoherence Timescales for Ionic Superposition States in Ion Channels
Creators: name: Salari, V.
name: Moradi, N.
name: Fazileh, F.
name: Shahbazi, F.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Biological Physics (physics.bio-ph)
subject: FOS: Physical sciences

description: There are many controversial and challenging discussions about quantum effects in microscopic structures in neurons of the human brain. The challenge is mainly because of quick decoherence of quantum states due to hot, wet and noisy environment of the brain which forbids long life coherence for brain processing. Despite these critical discussions, there are only a few number of published papers about numerical aspects of decoherence in neurons. Perhaps the most important issue is offered by Max Tegmark who has calculated decoherence times for the systems of "ions" and "microtubules" in neurons of the brain. In fact, Tegmark did not consider ion channels which are responsible for ions displacement through the membrane and are the building blocks of electrical membrane signals in the nervous system. Here, we would like to re-investigate decoherence times for ionic superposition states by using the data obtained via molecular dynamics simulations. Our main approach is according to what Tegmark has used before. In fact, Tegmark didn't consider the ion channel structure and his estimates are only simple approximations. In this paper, we focus on the small nano-scale part of KcsA ion channels which is called "selectivity filter" and has a key role in the operation of an ion channel. Our results for superposition states of potassium ions indicate that decoherence times are in the order of picoseconds which are 10-100 million times bigger than the order calculated by Tegmark. This decoherence time is still not enough for cognitive processing in the brain, however it can be adequate for quantum states of cooled ions in the filter to leave their quantum traces on the filter and action potentials.
description: 5 pages, 3 figures
Optimization of a large aperture dipole magnet for baryonic matter studies at Nuclotron
Creators: name: Akishin, P. G.
name: Isupov, A. Yu.
name: Khrenov, A. N.
name: Kurilkin, P. K.
name: Ladygin, V. P.
name: Piyadin, S. M.
name: Topilin, N. D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: The aperture of the dipole magnet SP41 has been enlarged for the studies of dense baryonic matter properties at Nuclotron. The homogeneity of the magnetic field in the magnet centre has been improved. The measurement results of the magnetic field components and integral are compared with results of 3D TOSCA calculations.
description: 10 pages, 9 figures
RKI-Ratgeber Hepatitis C
Creators: name: Koch-Institut, Robert
Publisher: name: Robert Koch-Institut
Year: 2018
Subjects: subject: 610 Medizin und Gesundheit

description: Im Epidemiologischen Bulletin 31/2018 ist der vor kurzem aktualisierte Hepatitis-C-Ratgeber veröffentlicht worden. Infektionen mit Hepatitis-C-Viren zählen zu den bedeutendsten Ursachen von Leberzirrhose und Leberzellkarzinom. Die meisten chronischen Infektionen können durch eine effektive medikamentöse Therapie geheilt und damit bei rechtzeitiger Behandlung Spätfolgen verhindert werden. Da die Infektion häufig asymptomatisch verläuft, sollten Gruppen mit hohem Risiko und erhöhter Prävalenz regelmäßig getestet werden. Zu den besonders betroffenen Gruppen gehören Personen, die sich Drogen injizieren, Haftinsassen und HIV-Infizierte. Hepatitis C wird in erster Linie auf dem Blutweg übertragen.
High SNR BER Comparison of Coherent and Differentially Coherent Modulation Schemes in Lognormal Fading Channels
Creators: name: Song, Xuegui
name: Cheng, Julian
name: Alouini, Mohamed-Slim
Publisher: name: arXiv
Year: 2014
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: Using an auxiliary random variable technique, we prove that binary differential phase-shift keying and binary phase-shift keying have the same asymptotic bit-error rate performance in lognormal fading channels. We also show that differential quaternary phase-shift keying is exactly 2.32 dB worse than quaternary phase-shift keying over the lognormal fading channels in high signal-to-noise ratio regimes.
description: Manuscript accepted for publication in IEEE Communications Letters (4 pages with 2 figures)
Towards phase transitions between discrete and continuum quantum spacetime from the Renormalization Group
Creators: name: Eichhorn, Astrid
name: Koslowski, Tim
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We establish the functional Renormalization Group as an exploratory tool to investigate a possible phase transition between a pre-geometric discrete phase and a geometric continuum phase in quantum gravity. In this paper, based on the analysis of [1], we study three new aspects of the double-scaling limit of matrix models as Renormalization Group fixed points: Firstly, we investigate multicritical fixed points, which are associated with quantum gravity coupled to conformal matter. Secondly, we discuss an approximation that reduces the scheme dependence of our results as well as computational effort while giving good numerical results. This is a consequence of the approximation being a solution to the unitary Ward-identity associated to the U(N) symmetry of the hermitian matrix model. Thirdly, we discuss a scenario that relates the double scaling limit to fixed points of continuum quantum gravity.
description: 14 pages, 1 figure
A Randomized Pilot Trial Comparing Position Emission Tomography (PET)-Guided Dose Escalation Radiotherapy to Conventional Radiotherapy in Chemoradiotherapy Treatment of Locally Advanced Nasopharyngeal Carcinoma
Creators: name: Tang, Tianyou
name: Wang, Jianshe
name: Yao, Yuanhu
name: Wang, Andrew Z.
name: Xu, Jing
name: Zheng, Junnian
name: Zhang, Longzhen
name: Zhu, Feng
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: BackgroundThis pilot trial is designed to determine whether PET/CT-guided radiotherapy dose escalation can improve local control while minimizing toxicity for the treatment of locally advanced nasopharyngeal carcinoma.Methods67 patients were randomized into the three treatment arms: conventional chemoradiotherapy (group A), CT-guided dose escalation chemoradiotherapy (group B) and PET/CT-guided dose escalation chemoradiotherapy (group C). Radiotherapy was delivered using the simultaneous modulated accelerated radiation therapy (SMART) technique in the dose-escalation treatment arms. Patients received concurrent and adjuvant chemotherapy.ResultsThe use of PET/CT significantly changed the treatment volume delineation of the gross tumor volume. 3-year local progression-free (LPF) survival rates of three groups were 83.3%, 90.9% and 100%, respectively. The 3-year regional progression-free survival (RPFS) rates were 95.8%, 95.5% and 100%, respectively. The 3-year disease free survival (DFS) rates were 79.2%, 86.4% and 95.2%, respectively. The 3-year overall survival (OS) rates were 83.3%, 90.9% and 95.2%, respectively. The 3-year disease-free survival (DFS) rates were 79.2%, 86.4% and 95.2%, respectively. No patient had grade 4 late toxicity.ConclusionsPET/CT-guided dose escalation radiotherapy is well-tolerated and appears to be superior to conventional chemoradiotherapy for locally advanced NPC.Trial RegistrationClinicalTrials.gov NCT02089204
Leserbrief zum Artikel „Große Unterschiede bei TB-, HIV-, HCV-Behandlung und Opioid- Substitutions-Therapie unter Gefangenen in Deutschland“ und Kommentar des RKI
Creators: name: Schmidt, Daniel
name: Müller, Jana
name: Kollan, Christian
name: Lehmann, Marc
name: Königstein, Bodo
name: Bremer, Viviane
name: Zimmermann, Ruth
Publisher: name: Robert Koch-Institut
Year: 2018
Subjects: subject: 610 Medizin und Gesundheit

description: In der Ausgabe Nr. 13 des Epidemiologischen Bulletins vom 29. März 2018 wurde eine Studie mit dem Titel "Große Unterschiede bei TB-, HIV-, HCV-Behandlung und Opioid-Substitutions-Therapie unter Gefangenen in Deutschland" vorgestellt. Bezüglich Tuberkulose (TB) hat das RKI eine Reihe von Kommentaren erhalten. Im Epidemiologischen Bulletin 31/2018 nehmen der Autor eines Leserbriefs und das RKI dazu gemeinsam Stellung. Dabei geht es um das Screening der Haftinsassen auf TB sowie um die beobachteten, teils großen Unterschiede in der Menge der an Justizvollzugsanstalten (JVAen) abgegebenen TB-Arzneimittel zwischen den Bundesländern und auch zwischen den JVAen.
A Systematic Review and Meta-Analysis of Fecal Contamination and Inadequate Treatment of Packaged Water
Creators: name: Cronk, Ryan
name: Kelly, Emma R.
name: Bartram, Jamie
name: Williams, Ashley R.
name: Bain, Robert E. S.
name: Fisher, Michael B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: BackgroundPackaged water products provide an increasingly important source of water for consumption. However, recent studies raise concerns over their safety.ObjectivesTo assess the microbial safety of packaged water, examine differences between regions, country incomes, packaged water types, and compare packaged water with other water sources.MethodsWe performed a systematic review and meta-analysis. Articles published in English, French, Portuguese, Spanish and Turkish, with no date restrictions were identified from online databases and two previous reviews. Studies published before April 2014 that assessed packaged water for the presence of Escherichia coli, thermotolerant or total coliforms were included provided they tested at least ten samples or brands.ResultsA total of 170 studies were included in the review. The majority of studies did not detect fecal indicator bacteria in packaged water (78/141). Compared to packaged water from upper-middle and high-income countries, packaged water from low and lower-middle-income countries was 4.6 (95% CI: 2.6–8.1) and 13.6 (95% CI: 6.9–26.7) times more likely to contain fecal indicator bacteria and total coliforms, respectively. Compared to all other packaged water types, water from small bottles was less likely to be contaminated with fecal indicator bacteria (OR = 0.32, 95%CI: 0.17–0.58) and total coliforms (OR = 0.10, 95%CI: 0.05, 0.22). Packaged water was less likely to contain fecal indicator bacteria (OR = 0.35, 95%CI: 0.20, 0.62) compared to other water sources used for consumption.ConclusionsPolicymakers and regulators should recognize the potential benefits of packaged water in providing safer water for consumption at and away from home, especially for those who are otherwise unlikely to gain access to a reliable, safe water supply in the near future. To improve the quality of packaged water products they should be integrated into regulatory and monitoring frameworks.
Quantum Cost Optimization for Reversible Sequential Circuit
Creators: name: Mamun, Md. Selim Al
name: Menville, David
Publisher: name: arXiv
Year: 2014
Subjects: subject: Emerging Technologies (cs.ET)
subject: FOS: Computer and information sciences

description: Reversible sequential circuits are going to be the significant memory blocks for the forthcoming computing devices for their ultra low power consumption. Therefore design of various types of latches has been considered a major objective for the researchers quite a long time. In this paper we proposed efficient design of reversible sequential circuits that are optimized in terms of quantum cost, delay and garbage outputs. For this we proposed a new 3*3 reversible gate called SAM gate and we then design efficient sequential circuits using SAM gate along with some of the basic reversible logic gates.
description: Quantum 4.12 (2013). arXiv admin note: substantial text overlap with arXiv:1312.7354
A Zebrafish Model for Studies on Esophageal Epithelial Biology
Creators: name: Chen, Xiaoxin
name: Hu, Yuhui
name: Chen, Hao
name: Beasley, Andrea
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Mammalian esophagus exhibits a remarkable change in epithelial structure during the transition from embryo to adult. However, the molecular mechanisms of esophageal epithelial development are not well understood. Zebrafish (Danio rerio), a common model organism for vertebrate development and gene function, has not previously been characterized as a model system for esophageal epithelial development. In this study, we characterized a piece of non-keratinized stratified squamous epithelium similar to human esophageal epithelium in the upper digestive tract of developing zebrafish. Under the microscope, this piece was detectable at 5dpf and became stratified at 7dpf. Expression of esophageal epithelial marker genes (Krt5, P63, Sox2 and Pax9) was detected by immunohistochemistry and in situ hybridization. Knockdown of P63, a gene known to be critical for esophageal epithelium, disrupted the development of this epithelium. With this model system, we found that Pax9 knockdown resulted in loss or disorganization of the squamous epithelium, as well as down-regulation of the differentiation markers Krt4 and Krt5. In summary, we characterized a region of stratified squamous epithelium in the zebrafish upper digestive tract which can be used for functional studies of candidate genes involved in esophageal epithelial biology.
Adeno-Associated Virus Vector Mediated Delivery of the HBV Genome Induces Chronic Hepatitis B Virus Infection and Liver Fibrosis in Mice
Creators: name: Liu, Zhong
name: Zhang, Liguo
name: Ye, Lei
name: Yu, Haisheng
name: Li, Wuping
name: Samulski, R. Jude
name: Li, Chengwen
name: Hirsch, Matthew L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Liver cirrhosis and hepatocellular carcinomas are major health problems of chronic hepatitis B virus (HBV) infection. To date, rare model has reproduced liver fibrosis associated with long-term HBV infection which in turn has hindered both the understanding of HBV biology and the development of new treatment options. Here, using adeno-associated virus serotype 8 (AAV8) mediated delivery of a 1.2-kb HBV genome, we successfully generated a chronic HBV infectious mouse model that presents the associated liver fibrosis observed following human infection. After AAV8/HBV1.2 vector administration, mice demonstrated effective HBV replication and transcription which resulted in HBV antigen expression and viremia over 6 months. Although no obvious acute inflammatory response was noted, these mice still developed chronic liver disease and hepatic fibrogenesis as demonstrated by increased ground glass-like hepatocytes, an increasing trend of collagen deposition and upregulated fibrosis markers, including type I collagen, type III collagen, tissue inhibitor of metalloproteinase (TIMP), and transforming growth factor-β1(TGF-β1). Taken together, AAV-mediated HBV gene delivery to the mouse liver, induced HBV persistent infection accompanied by liver fibrosis which can serve as a model for investigating the precise mechanisms underlying liver fibrosis following chronic HBV infection as well as for the potential development of novel therapeutics.
How to determine an exomoon's sense of orbital motion
Creators: name: Heller, René
name: Albrecht, Simon
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We present two methods to determine an exomoon's sense of orbital motion (SOM), one with respect to the planet's circumstellar orbit and one with respect to the planetary rotation. Our simulations show that the required measurements will be possible with the European Extremely Large Telescope (E-ELT). The first method relies on mutual planet-moon events during stellar transits. Eclipses with the moon passing behind (in front of) the planet will be late (early) with regard to the moon's mean orbital period due to the finite speed of light. This "transit timing dichotomy" (TTD) determines an exomoon's SOM with respect to the circumstellar motion. For the ten largest moons in the solar system, TTDs range between 2 and 12 s. The E-ELT will enable such measurements for Earth-sized moons around nearby stars. The second method measures distortions in the IR spectrum of the rotating giant planet when it is transited by its moon. This Rossiter-McLaughlin effect (RME) in the planetary spectrum reveals the angle between the planetary equator and the moon's circumplanetary orbital plane, and therefore unveils the moon's SOM with respect to the planet's rotation. A reasonably large moon transiting a directly imaged planet like beta Pic b causes an RME amplitude of almost 100 m/s, about twice the stellar RME amplitude of the transiting exoplanet HD209458b. Both new methods can be used to probe the origin of exomoons, that is, whether they are regular or irregular in nature.
description: accepted by ApJ Letters, 6 pages, 5 figures (2 color)
Adolescent Intermittent Alcohol Exposure: Deficits in Object Recognition Memory and Forebrain Cholinergic Markers
Creators: name: Miller, Kelsey M.
name: Sexton, Hannah G.
name: Liu, Wen
name: Risher, Mary-Louise
name: Swartzwelder, H. Scott
name: Crews, Fulton T.
name: Acheson, Shawn K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The long-term effects of intermittent ethanol exposure during adolescence (AIE) are of intensive interest and investigation. The effects of AIE on learning and memory and the neural functions that drive them are of particular interest as clinical findings suggest enduring deficits in those cognitive domains in humans after ethanol abuse during adolescence. Although studies of such deficits after AIE hold much promise for identifying mechanisms and therapeutic interventions, the findings are sparse and inconclusive. The present results identify a specific deficit in memory function after AIE and establish a possible neural mechanism of that deficit that may be of translational significance. Male rats (starting at PND-30) received exposure to AIE (5g/kg, i.g.) or vehicle and were allowed to mature into adulthood. At PND-71, one group of animals was assessed using the spatial-temporal object recognition (stOR) test to evaluate memory function. A separate group of animals was used to assess the density of cholinergic neurons in forebrain areas Ch1-4 using immunohistochemistry. AIE exposed animals manifested deficits in the temporal component of the stOR task relative to controls, and a significant decrease in the number of ChAT labeled neurons in forebrain areas Ch1-4. These findings add to the growing literature indicating long-lasting neural and behavioral effects of AIE that persist into adulthood and indicate that memory-related deficits after AIE depend upon the tasks employed, and possibly their degree of complexity. Finally, the parallel finding of diminished cholinergic neuron density suggests a possible mechanism underlying the effects of AIE on memory and hippocampal function as well as possible therapeutic or preventive strategies for AIE.
Distinguishability, degeneracy and correlations in three harmonically trapped bosons in one-dimension
Creators: name: García-March, M. A.
name: Juliá-Díaz, B.
name: Astrakharchik, G. E.
name: Boronat, J.
name: Polls, A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We study a system of two bosons of one species and a third boson of a second species in a one-dimensional parabolic trap at zero temperature. We assume contact repulsive inter- and intra-species interactions. By means of an exact diagonalization method we calculate the ground and excited states for the whole range of interactions. We use discrete group theory to classify the eigenstates according to the symmetry of the interaction potential. We also propose and validate analytical ansatzs gaining physical insight over the numerically obtained wavefunctions. We show that, for both approaches, it is crucial to take into account that the distinguishability of the third atom implies the absence of any restriction over the wavefunction when interchanging this boson with any of the other two. We find that there are degeneracies in the spectra in some limiting regimes, that is, when the inter-species and/or the intra-species interactions tend to infinity. This is in contrast with the three-identical boson system, where no degeneracy occurs in these limits. We show that, when tuning both types of interactions through a protocol that keeps them equal while they are increased towards infinity, the systems's ground state resembles that of three indistinguishable bosons. Contrarily, the systems's ground state is different from that of three-identical bosons when both types of interactions are increased towards infinity through protocols that do not restrict them to be equal. We study the coherence and correlations of the system as the interactions are tuned through different protocols, which permit to built up different correlations in the system and lead to different spatial distributions of the three atoms.
description: 14 pages, 7 figures
An Allergic Lung Microenvironment Suppresses Carbon Nanotube-Induced Inflammasome Activation via STAT6-Dependent Inhibition of Caspase-1
Creators: name: Bonner, James C.
name: Shipkowski, Kelly A.
name: Taylor, Alexia J.
name: Messenger, Zachary J.
name: Sayers, Brian C.
name: Glista-Baker, Ellen E.
name: Thompson, Elizabeth A.
name: Jaspers, Ilona
name: Bauer, Rebecca N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: BackgroundMulti-walled carbon nanotubes (MWCNTs) represent a human health risk as mice exposed by inhalation display pulmonary fibrosis. Production of IL-1β via inflammasome activation is a mechanism of MWCNT-induced acute inflammation and has been implicated in chronic fibrogenesis. Mice sensitized to allergens have elevated T-helper 2 (Th2) cytokines, IL-4 and IL-13, and are susceptible to MWCNT-induced airway fibrosis. We postulated that Th2 cytokines would modulate MWCNT-induced inflammasome activation and IL-1β release in vitro and in vivo during allergic inflammation.MethodsTHP-1 macrophages were primed with LPS, exposed to MWCNTs and/or IL-4 or IL-13 for 24 hours, and analyzed for indicators of inflammasome activation. C57BL6 mice were sensitized to house dust mite (HDM) allergen and MWCNTs were delivered to the lungs by oropharyngeal aspiration. Mice were euthanized 1 or 21 days post-MWCNT exposure and evaluated for lung inflammasome components and allergic inflammatory responses.ResultsPriming of THP-1 macrophages with LPS increased pro-IL-1β and subsequent exposure to MWCNTs induced IL-1β secretion. IL-4 or IL-13 decreased MWCNT-induced IL-1β secretion by THP-1 cells and reduced pro-caspase-1 but not pro-IL-1β. Treatment of THP-1 cells with STAT6 inhibitors, either Leflunomide or JAK I inhibitor, blocked suppression of caspase activity by IL-4 and IL-13. In vivo, MWCNTs alone caused neutrophilic infiltration into the lungs of mice 1 day post-exposure and increased IL-1β in bronchoalveolar lavage fluid (BALF) and pro-caspase-1 immuno-staining in macrophages and airway epithelium. HDM sensitization alone caused eosinophilic inflammation with increased IL-13. MWCNT exposure after HDM sensitization increased total cell numbers in BALF, but decreased numbers of neutrophils and IL-1β in BALF as well as reduced pro-caspase-1 in lung tissue. Despite reduced IL-1β mice exposed to MWCNTs after HDM developed more severe airway fibrosis by 21 days and had increased pro-fibrogenic cytokine mRNAs.ConclusionsThese data indicate that Th2 cytokines suppress MWCNT-induced inflammasome activation via STAT6-dependent down-regulation of pro-caspase-1 and suggest that suppression of inflammasome activation and IL-1β by an allergic lung microenvironment is a mechanism through which MWCNTs exacerbate allergen-induced airway fibrosis.
Hong Kong Migrants’ Divergent Experiences in Australia: A Multi-level Spatio-temporal Approach
Creators: name: Lee, Man Yee Karen
name: Lui, Lake
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 5204
subject: Cognitive and computational psychology
classificationCode: 5202
subject: Biological psychology
classificationCode: 5203
subject: Clinical and health psychology

description: No description supplied
Gelebte Achtsamkeit in der Primarschule. Eine systematische Literaturarbeit über die Möglichkeiten zum Aufbau emotionaler Kompetenzen durch Achtsamkeit
Creators: name: Hõbejõgi, Kathrin
Publisher: name: Zenodo
Year: 2022
Subjects: Sonderpädagogik
Masterarbeit
Achtsamkeit
emotionale Kompetenzen
Primarschule

description: Diese Literaturarbeit beleuchtet die Möglichkeiten eines achtsamen Unterrichts in der Primarschule und seine Auswirkungen auf die emotionalen Kompetenzen. Mittels einer qualitativen Inhaltsanalyse von 16 ausgewählten Texten aus Büchern und Studien zum Thema wird der folgenden Fragestellung nachgegangen: Welche Möglichkeiten bietet ein auf Achtsamkeit basierender Unterricht für die Kinder in der Primarschule in Bezug auf ihre emotionalen Kompetenzen? Als Ergebnis wurde sichtbar, dass auf den emotionalen Kompetenzen soziale Kompetenzen und ein besseres lernförderliches Klima erarbeitet werden können, was sich positiv auf die Selbstwirksamkeitserwartung der Kinder auswirkt. Wie sich herausstellte bildet dabei eine offene, achtsame Haltung der Lehrperson eine wichtige Basis. Hierzu wurde ein Modell entwickelt, um dieses Konzept vorzustellen, das die Wichtigkeit der Lehrperson als Vorbild in den Vordergrund stellt.