cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Imaging techniques utilised for breast cancer screening in patients with BRCA gene mutations – a retrospective, 4 year, single-centre series.
Creators: name: Ajjikuttira, Aiyapa
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2023
Subjects: subject: Breast
subject: CT
subject: MR
subject: Ultrasound
subject: Outcomes analysis
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: An estimated 1 in 7 women are diagnosed with breast cancer in their lifetime. 1 Women with mutations in the BRCA1 and BRCA2 genes, belonging to the tumour suppressor gene family, have an approximately 75% lifetime risk of developing this disease. 2...
Core global metrics of chronic kidney disease (CKD) mortality in the GBD 2019 Study
Creators: name: Boris, Bikbov
Publisher: name: Zenodo
Year: 2023
Subjects: kidney
Global Health
Public Health
chronic kidney disease
impaired kidney function
CKD
Global Burden of Disease Study
GBD
epidemiology
mortality

description: Chronic kidney disease (CKD) is an important contributor to morbidity and mortality from noncommunicable diseases, and is highly relevant topic in global health. The Global Burden of Disease, Injuries and Risk Factors (GBD) study presents a comprehensive assessment of the global epidemiology of CKD both as a direct cause of mortality and morbidity and as a risk factor for other diseases. The GBD uses term "impaired kidney function (IKF)" to indicate the CKD as a risk factor for ischaemic heart disease, stroke, peripheral vascular disease, and gout, and underline the difference from the term "CKD" itself that refers to a direct cause of morbidity and mortality due to kidney disease. Scientific-Tools.Org created a series of infographics highlighting different aspects of CKD epidemiology at global, regional and country levels. This work is licensed under a Creative Commons Attribution NoDerivatives License. See other infographics on CKD epidemiology: https://scientific-tools.org/portfolio-item/infographics-on-chronic-kidney-disease-ckd-epidemiology
Intra-Arterial Urokinase for Acute Superior Mesenteric Artery Occlusion: A Retrospective 12-Year Report of 13 Cases
Creators: name: Lin, Being-Chuan
name: Wong, Yon-Cheong
name: Hsin, Ming-Che
name: Wu, Cheng-Hsien
name: Hung, Sheng-Che
Publisher: name: MDPI
Year: 2023

description: This retrospective study aimed to evaluate the outcomes of 13 patients with acute superior mesenteric artery (SMA) occlusion who underwent intra-arterial urokinase thrombolysis between 2008 and 2020. On angiography, seven presented with complete SMA occlusion versus six with incomplete occlusion. The median time from abdominal pain to attempting urokinase thrombolysis was 15.0 h (interquartile range, 6.0 h). After urokinase therapy, bowel perfusion was restored with bowel preservation in six patients; however, treatment failed in the other seven patients. The degree of SMA occlusion (complete vs. incomplete, p = 0.002), degree of recanalisation (p = 0.012), and length of stay (p = 0.032) differed significantly between groups. Of the seven patients with complete SMA occlusion, six underwent bowel resection, of whom three died, and the remaining patient died of shock due to delayed surgery. Among the six patients with incomplete SMA occlusion, no bowel resection was performed. In our experience, intra-arterial urokinase thrombolysis may serve as an adjunctive treatment modality, being a potential replacement for open thrombectomy that is able to preserve the bowel and obviate surgery in cases of incomplete SMA occlusion; however, its use is unsuitable in cases of complete SMA occlusion, for which surgery is warranted.
Regulatory (Mal)Integration: Its Implications for Migrant Workers’ Ability to Access Employment Rights in Indonesia
Creators: name: Palmer, Wayne
name: Piper, Nicola
Publisher: name: figshare
Year: 2023
Subjects: Migration
Government and politics of Asia and the Pacific

description: This paper discusses the understudied situation of legally-resident migrants and their (in)ability to access employment rights that are otherwise available to Indonesians. In our analysis of the relevant institutional architecture and processes, we approach the issue of integration from a regulatory perspective. We used a combination of quantitative and qualitative methods to examine how migrants as high-income workers interface with the labor dispute resolution system in Indonesia. Our findings demonstrate the mal-integrated nature of Indonesia’s regulatory system in relation to migration and employment and its consequences for migrant workers’ ability to lodge grievances and avail themselves of their employment rights.
title: Interventions and outcomes for upper extremity deep vein thrombosis: a proposed retrospective cohort study
Creators: name: Paparo, Alannah
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2023
Subjects: subject: Interventional vascular
subject: Vascular
subject: Veins / Vena cava
subject: Catheter venography
subject: Catheters
subject: Recanalisation
subject: Thrombolysis
subject: Embolism / Thrombosis

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Upper extremity deep vein thrombosis (UEDVT) accounts for 5% of all DVTs 1 . 70-80% of UEDVT is secondary to provoking agents including indwelling devices, malignancy, and thrombophilia. Primary UEDVT, or Paget-Schroetter syndrome (PSS), is a less...
Robust, ultrasmall organosilica nanoparticles without silica shells
Creators: name: Murray, Eoin
name: Born, Philip
name: Weber, Anika
name: Kraus, Tobias
Publisher: name: Heidelberg : Springer
Year: 2014
Subjects: subject: Nanoparticle synthesis
subject: Stöber process
subject: organosilica
subject: micelles
subject: 540

description: Traditionally, organosilica nanoparticles have been prepared inside micelles with an external silica shell for mechanical support. Here, we compare these hybrid core–shell particles with organosilica particles that are robust enough to be produced both inside micelles and alone in a sol–gel process. These particles form from octadecyltrimethoxy silane as silica source either in microemulsions, resulting in water-dispersible particles with a hydrophobic core, or precipitate from an aqueous mixture to form particles with both hydrophobic core and surface. We examine size and morphology of the particles by dynamic light scattering and transmission electron microscopy and show that the particles consist of Si–O–Si networks pervaded by alkyl chains using nuclear magnetic resonance, infrared spectroscopy, and thermogravimetric analysis.
title: Comparison of PET PSMA findings in an individual with pathological neuroendocrine transdifferentiation of metastatic castration-resistant prostate cancer
Creators: name: Hu, Yuchen
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2023
Subjects: subject: Molecular imaging
subject: Nuclear medicine
subject: Oncology
subject: PET
subject: Biopsy
subject: Molecular imaging
subject: Cancer
subject: Image verification
subject: Pathology

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: This study aims to advance our understanding of the role of PSMA PET in context of castrate-resistant prostate cancer with treatment-related neuroendocrine...
Robust criterion for the existence of nonhyperbolic ergodic measures
Creators: name: Bochi, Jairo
name: Bonatti, Christian
name: Díaz, Lorenzo J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 37D30, 37C40, 37D25, 37A35

description: We give explicit $C^1$-open conditions that ensure that a diffeomorphism possesses a nonhyperbolic ergodic measure with positive entropy. Actually, our criterion provides the existence of a partially hyperbolic compact set with one-dimensional center and positive topological entropy on which the center Lyapunov exponent vanishes uniformly. The conditions of the criterion are met on a $C^1$-dense and open subset of the set of a diffeomorphisms having a robust cycle. As a corollary, there exists a $C^1$-open and dense subset of the set of non-Anosov robustly transitive diffeomorphisms consisting of systems with nonhyperbolic ergodic measures with positive entropy. The criterion is based on a notion of a blender defined dynamically in terms of strict invariance of a family of discs.
Additional file 9 of Health Benefits of Different Sports: a Systematic Review and Meta-Analysis of Longitudinal and Intervention Studies Including 2.6 Million Adult Participants
Creators: name: Oja, Pekka
name: Memon, Aamir Raoof
name: Titze, Sylvia
name: Jurakic, Danijel
name: Chen, Si-Tong
name: Shrestha, Nipun
name: Em, Sowannry
name: Matolic, Tena
name: Vasankari, Tommi
name: Heinonen, Ari
name: Grgic, Jozo
name: Koski, Pasi
name: Kokko, Sami
name: Kelly, Paul
name: Foster, Charlie
name: Podnar, Hrvoje
name: Pedisic, Zeljko
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Cancer
Science Policy

description: Additional file 9: The effects of handball on health outcomes: results of 12 sensitivity meta-analyses in which missing correlations were replaced with 0.50.
Discretized Weyl-orbit functions: modified multiplication and Galois symmetry
Creators: name: Hrivnák, Jiří
name: Walton, Mark A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mathematical Physics (math-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We note a remarkable similarity between the discretized Weyl-orbit functions and affine modular data associated with Wess-Zumino-Novikov-Witten (WZNW) conformal field theories. Known properties of the modular data are exploited here to uncover analogous results for the discretized orbit functions. We show that the product of orbit functions is modified in analogy with the truncation of tensor products known as affine fusion, governing the interactions in WZNW models. A Galois symmetry, like that of affine modular data, is also described for the discretized orbit functions.
description: 13 pages, 3 figures
title: A case of spontaneous retroperitoneal haemorrhage: PAN, SAM, or something else?
Creators: name: Paparo, Alannah
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2023
Subjects: subject: Abdomen
subject: Arteries / Aorta
subject: Interventional vascular
subject: Catheter arteriography
subject: CT-Angiography
subject: Embolisation
subject: Aneurysms
subject: Arthritides
subject: Haemorrhage

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: Present an unusual case of polyarteritis nodosa (PAN) presenting with spontaneous retroperitoneal haemorrhage in a patient with widespread vascular abnormalities Review anatomical variants of abdominal vasculature Outline clinical, biochemical and...
Physiological analysis of human performance: a study of extreme fatigue and violent effort during sporting activities
Creators: name: Thomas, Vaughan
Publisher: name: Loughborough University
Year: 2020
Subjects: subject: 119999 Medical and Health Sciences not elsewhere classified
subject: FOS: Other medical sciences

description: Physiological analysis of human performance: a study of extreme fatigue and violent effort during sporting activities
MS0621, a novel small-molecule modulator of Ewing sarcoma chromatin accessibility, interacts with an RNA-associated macromolecular complex and influences RNA splicing
Creators: name: Pattenden, Samantha G.
name: Jin, Jian
name: Frye, Stephen V.
name: Marcel, Shelsa S.
name: Mosely, Amber L.
name: Butler, Kyle V.
name: Wali, Aminah
name: Xiong, Yan
name: Vital, Tamara
name: Davis, Ian J.
name: Lamb, Kelsey N.
name: Nguyen, Valerie U.
name: McFadden, Andrew W.
name: Foster, Joseph P.
name: Bailey, Benton M.
name: James, Lindsey I.
Publisher: name: Frontiers Media S.A.
Year: 2023

description: Ewing sarcoma is a cancer of children and young adults characterized by the critical translocation-associated fusion oncoprotein EWSR1::FLI1. EWSR1::FLI1 targets characteristic genetic loci where it mediates aberrant chromatin and the establishment of de novo enhancers. Ewing sarcoma thus provides a model to interrogate mechanisms underlying chromatin dysregulation in tumorigenesis. Previously, we developed a high-throughput chromatin-based screening platform based on the de novo enhancers and demonstrated its utility in identifying small molecules capable of altering chromatin accessibility. Here, we report the identification of MS0621, a molecule with previously uncharacterized mechanism of action, as a small molecule modulator of chromatin state at sites of aberrant chromatin accessibility at EWSR1::FLI1-bound loci. MS0621 suppresses cellular proliferation of Ewing sarcoma cell lines by cell cycle arrest. Proteomic studies demonstrate that MS0621 associates with EWSR1::FLI1, RNA binding and splicing proteins, as well as chromatin regulatory proteins. Surprisingly, interactions with chromatin and many RNA-binding proteins, including EWSR1::FLI1 and its known interactors, were RNA-independent. Our findings suggest that MS0621 affects EWSR1::FLI1-mediated chromatin activity by interacting with and altering the activity of RNA splicing machinery and chromatin modulating factors. Genetic modulation of these proteins similarly inhibits proliferation and alters chromatin in Ewing sarcoma cells. The use of an oncogene-associated chromatin signature as a target allows for a direct approach to screen for unrecognized modulators of epigenetic machinery and provides a framework for using chromatin-based assays for future therapeutic discovery efforts.
Comparison of Soil pH and Exchangeable Cation Quantification by Various Wet Methods with Near- and Mid-Infrared Spectroscopy Prediction
Creators: name: Nel, T.
name: Clarke, C.E.
name: Hardie, A.G.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biophysics
Biochemistry
Pharmacology
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Rapid soil analyses can be obtained by infrared (IR) spectroscopy, but few studies have evaluated the suitability of different reference wet chemical methods to calibrate models predicting soil fertility. The aim of this study was to assess the accuracy of IR spectral-based models for the determination of soil pH measured in water, potassium chloride (KCl), and calcium chloride (CaCl2), and exchangeable basic cation content measured by the ammonium acetate (NH4OAc, 1 M and 0.02 M variations, pH = 7), Mehlich-III, Ambic-I, citric acid (1%), compulsive exchange, and Bray-II methods. Near- to mid-infrared (NIR, MIR) spectral-based models predicting soil pH and exchangeable cations measures were calibrated by partial least squares regression for a set of soils containing highly and intermediately weathered clay minerals and variable sesquioxide contents. The ratio of root mean square error of prediction (RMESP) to analyte component range was compared to a threshold value for contextual model accuracy assessment. pH measurements in CaCl2 matrices led to better calibrations and predictions of soil pH by IR spectral models compared to pH measurements in water and KCl matrices. Exchangeable calcium (Ca) and magnesium (Mg) concentrations determined by compulsive exchange and the NH4OAc (1 M, pH = 7) extraction methods, respectively, were most accurately predicted by NIR spectral-based models (RMSEP = 1.2–1.4 and 0.37 cmolc kg−1, respectively). The ratio of performance to inter-quartile distance (RPIQ) is recommended as an alternative figure of merit to traditionally reported ratio of performance to deviation (RPD) for IR spectral-based models predicting soil chemical properties. Subsetting soil samples by similarities in physiochemical properties improved the accuracy of soil pH and exchangeable Ca content predictions.
MicroRNA-eQTLs in the developing human neocortex link miR-4707-3p expression to brain size
Creators: name: Lafferty, Michael J
name: Krupa, Oleh
name: Wolter, Justin M
name: Liang, Dan
name: Geschwind, Daniel H
name: Stein, Jason L
name: de la Torre-Ubieta, Luis
name: Aygün, Nil
name: Patel, Niyanta K
Publisher: name: eLife
Year: 2023

description: Expression quantitative trait loci (eQTL) data have proven important for linking non-coding loci to protein-coding genes. But eQTL studies rarely measure microRNAs (miRNAs), small non-coding RNAs known to play a role in human brain development and neurogenesis. Here, we performed small-RNA sequencing across 212 mid-gestation human neocortical tissue samples, measured 907 expressed miRNAs, discovering 111 of which were novel, and identified 85 local-miRNA-eQTLs. Colocalization of miRNA-eQTLs with GWAS summary statistics yielded one robust colocalization of miR-4707–3p expression with educational attainment and brain size phenotypes, where the miRNA expression increasing allele was associated with decreased brain size. Exogenous expression of miR-4707–3p in primary human neural progenitor cells decreased expression of predicted targets and increased cell proliferation, indicating miR-4707–3p modulates progenitor gene regulation and cell fate decisions. Integrating miRNA-eQTLs with existing GWAS yielded evidence of a miRNA that may influence human brain size and function via modulation of neocortical brain development.
title: Medical students’ perceptions of radiology education and attitudes towards radiology
Creators: name: Abar, Amir
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2023
Subjects: subject: Anatomy
subject: Other
subject: Education
subject: Education and training

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Medical education transformed immensely in the past decade and has more recently become increasingly digitised. These changes have been accelerated by COVID-19. However, throughout this modernisation, it is suggested that there is a continued...
Transformation of epitaxial NiMnGa/InGaAs nanomembranes grown on GaAs substrates into freestanding microtubes
Creators: name: Müller, C.
name: Neckel, I.
name: Monecke, M.
name: Dzhagan, V.
name: Salvan, G.
name: Schulze, S.
name: Baunack, S.
name: Gemming, T.
name: Oswald, S.
name: Engemaiere, V.
name: Mosca, D.H.
Publisher: name: Cambridge : Royal Society of Chemistry
Year: 2016
Subjects: subject: Cylinders (shapes)
subject: Electric windings
subject: Gallium
subject: Gallium alloys
subject: Gallium arsenide
subject: Magnetic properties
subject: Manganese
subject: Molecular beam epitaxy
subject: Nickel
subject: Semiconducting gallium
subject: 620

description: We report the fabrication of Ni2.7Mn0.9Ga0.4/InGaAs bilayers on GaAs (001)/InGaAs substrates by molecular beam epitaxy. To form freestanding microtubes the bilayers have been released from the substrate by strain engineering. Microtubes with up to three windings have been successfully realized by tailoring the size and strain of the bilayer. The structure and magnetic properties of both, the initial films and the rolled-up microtubes, are investigated by electron microscopy, X-ray techniques and magnetization measurements. A tetragonal lattice with c/a = 2.03 (film) and c/a = 2.01 (tube) is identified for the Ni2.7Mn0.9Ga0.4 alloy. Furthermore, a significant influence of the cylindrical geometry and strain relaxation induced by roll-up on the magnetic properties of the tube is found.
title: Conus Medullaris Hemangioblastoma with Arteriovenous Shunting a Diagnostic Challenge
Creators: name: Sharma, Rushil
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2023
Subjects: subject: Neuroradiology spine
subject: MR
subject: Other
subject: Cancer

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: Differentiating solitary intramedullary lesions on MRI is difficult and poses a diagnostic challenge especially in delineating Ependymoma and Hemangioblastoma. 1 This case report demonstrates intralesional arteriovenous shunting which has previously...
title: An AI model can identify implantable cardiac rhythm devices on chest x-rays
Creators: name: Pataky, Kristopher
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2023
Subjects: subject: Artificial Intelligence
subject: Cardiac
subject: Computer applications
subject: Conventional radiography
subject: Plain radiographic studies
subject: Computer Applications-Detection, diagnosis
subject: Computer Applications-General
subject: Other

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Identification of implantable cardiac rhythm devices (ICRD) is necessary to interrogate device history, program function, and clear the patient for MRI imaging. A patient’s device information is not always available, which can lead to delays in...
Interference-induced surface superconductivity:Enhancement by tuning the Debye energy
Creators: name: Bai, Yunfei
name: Chen, Yajiang
name: Croitoru, M. D.
name: Shanenko, A. A.
name: Luo, Xiaobing
name: Zhang, Yunbo
Publisher: name: arXiv
Year: 2023
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: In the usual perception, surface superconductivity is associated with the surface nucleation of a superconducting condensate above the upper critical field in type-II superconductors or with a rearrangement of phonon properties and the electron-phonon coupling near surfaces/interfaces. Recently, it has been found that there is another example when the surface superconducting temperature is increased up to 20-25% as compared to the bulk one due to constructive interference of superconducting pair states. In the present work, we demonstrate that in fact, such an interferenceinduced enhancement can be much more pronounced, up to nearly 70%. Furthermore, here it is shown that such an interference enhancement persists over a wide range of microscopic parameters.
Imaging exciton-polariton transport in MoSe2 waveguides
Creators: name: Hu, Fengrui
name: Luan, Yilong
name: Scott, M. E.
name: Yan, Jiaqiang
name: Mandrus, D. G.
name: Xu, Xiaodong
name: Fei, Z
Publisher: name: arXiv
Year: 2023
Subjects: subject: Optics (physics.optics)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The exciton polariton (EP), a half-light and half-matter quasiparticle, is potentially an important element for future photonic and quantum technologies. It provides both strong light-matter interactions and long-distance propagation that is necessary for applications associated with energy or information transfer. Recently, strongly-coupled cavity EPs at room temperature have been demonstrated in van der Waals (vdW) materials due to their strongly-bound excitons. Here we report a nano-optical imaging study of waveguide EPs in MoSe2, a prototypical vdW semiconductor. The measured propagation length of the EPs is sensitive to the excitation photon energy and reaches over 12 μm. The polariton wavelength can be conveniently altered from 600 nm down to 300 nm by controlling the waveguide thickness. Furthermore, we found an intriguing mode back-bending dispersion close to the exciton resonance. The observed EPs in vdW semiconductors could be useful in future nanophotonic circuits operating in the near-infrared to visible spectral regions.
description: 21 pages
A new Definition and Classification of Physical Unclonable Functions
Creators: name: Plaga, Rainer
name: Merli, Dominik
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences
subject: K.6.5; H.3.0

description: A new definition of "Physical Unclonable Functions" (PUFs), the first one that fully captures its intuitive idea among experts, is presented. A PUF is an information-storage system with a security mechanism that is 1. meant to impede the duplication of a precisely described storage-functionality in another, separate system and 2. remains effective against an attacker with temporary access to the whole original system. A novel classification scheme of the security objectives and mechanisms of PUFs is proposed and its usefulness to aid future research and security evaluation is demonstrated. One class of PUF security mechanisms that prevents an attacker to apply all addresses at which secrets are stored in the information-storage system, is shown to be closely analogous to cryptographic encryption. Its development marks the dawn of a new fundamental primitive of hardware-security engineering: cryptostorage. These results firmly establish PUFs as a fundamental concept of hardware security.
description: 6 pages, 3 figures; Proceedings "CS2 '15 Proceedings of the Second Workshop on Cryptography and Security in Computing Systems", Amsterdam, 2015, ACM Digital Library
title: Pulmonary artery migration and endovascular retrieval of Implanon NXT: Case discussion and imaging findings
Creators: name: Flory, Daniel
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2023
Subjects: subject: Interventional vascular
subject: Lung
subject: Pulmonary vessels
subject: CT
subject: Removal
subject: Foreign bodies

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Endovascular migration of an Implanon NXT to the lung vasculature is a rare but significant complication of a commonly available contraceptive. This pictorial case focuses on the clinical presentation, diagnosis, imaging findings and successful...
Additional file 6 of Dysregulation of innate immune signaling in animal models of spinal muscular atrophy
Creators: name: Garcia, Eric L.
name: Steiner, Rebecca E.
name: Raimer, Amanda C.
name: Herring, Laura E.
name: Matera, A. Gregory
name: Spring, Ashlyn M.
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: Computational Biology

description: Additional file 6: Figure S1. Isoform-specific differences in Smn mutants versus controls. A) Volcano plot of differentially expressed transcripts in Smn null animals. Transcripts associated with innate immunity are indicated with red circles and a subset of those are labeled with transcript symbols for the specific mRNA isoform difference. The axes correspond to: a Benjamini-Hochberg (False Discovery Rate (FDR) < 0.05) adjusted p-value (qval) and a Wald test-derived representation of a normalized fold change (beta factor). B) The heat map displays the respective mean transcripts per million reads for the different genotypes used in (A). The values are scaled and normalized per row (z-score). The heat map shows approximately half of the differentially expressed transcripts from (A). C) Scatter plot comparison of isoform-specific protein changes identified in the V72G proteome versus isoform-specific RNA changes found in the Smn null transcriptome. RNA and proteins associated with innate immunity are represented with larger dots and labeled. Figure S2. Evaluation of protein–protein interactions. A) GST-pulldown experiment using recombinant human SMN•Gem2 [22] and GST-TRAF6. GST and GST-TRAF6 were expressed in E.coli and purified using anti-Glutathione beads. Pulldown assays were performed and analyzed by western blotting with either anti-hSMN (top) or anti-GST (bottom) antibodies. As shown, GST-hTRAF6 interacts directly with human SMN•Gem2. B) Flag-pulldown experiment using lysates from tub-Gal4 > UAS:Flag-dTraf6 animals (Flag-Traf6) or from control animals bearing a Flag-Smn transgene [18] as the only source of SMN protein (Flag-SMN). Inputs are on the left and proteins eluted from the Flag beads following pulldowns are on the right. As shown, Flag-SMN co-purifies with itself in the control lysates but Flag-Traf6 fails to pull down endogenous dSMN in the experimental cross.
Aid and Radicalization: The Case of Hamas in the West Bank and Gaza
Creators: name: Loewenthal, Amit
name: Miaari, Sami H.
name: Hoeffler, Anke
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Medicine
Molecular Biology
Pharmacology
Cancer
Science Policy
Mental Health
Computational Biology

description: We study how militant political factions use material aid to secure support. We focus on Hamas, a militant faction in the Palestinian Authority. We generate a unique dataset that includes the sources and extent of assistance received by Palestinian households, data on Israeli and Palestinian fatalities, and data on the level of support for particular Palestinian factions. We find that lower-income residents of districts that receive aid from religious charities are more likely to support Hamas. The support patterns identified partly align with the existing theory on armed religious groups as club good providers. We find no evidence that aid affects incumbent support or deters recipients from supporting militants. While it is possible that charities only target districts and households that support them, testing for reverse causality by regressing aid on lagged faction support yields no such evidence.
title: Hepatic Artery Pseudoaneurysm following Liver Transplantation; Open and Endovascular Treatment Options
Creators: name: Pereira, Ryan
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2023
Subjects: subject: Interventional vascular
subject: CT-Angiography
subject: Embolisation
subject: Stents
subject: Transplantation

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Hepatic artery pseudoaneurysm (HAP) is a rare vascular complication following LTx, with an incidence ranging from 0.5 to 2.5% . (1, 3, 5, 7-9, 11) Approximately 10% of hepatic grafts are lost from HAP, mainly due to biliary tract devascularization....
Investigating the Impacts of Urban Built Environment on Travel Energy Consumption: A Case Study of Ningbo, China
Creators: name: Xue, Binxia
name: Wu, Wei
name: Ma, Tao
name: Song, Yan
name: Gong, Xujie
Publisher: name: MDPI
Year: 2023

description: The built environment of cities has increasingly affected the travel mode of residents and led to changes in energy consumption, which is crucial to maintaining urban sustainability. Ningbo is a typical representative of urbanization on the east coast of China, and its energy consumption is in a period of rapid growth. Therefore, using the survey data of 22,112 traffic trip samples from nine streets in Ningbo, this paper establishes a regression analysis model, systematically analyzes the relationship between the built environment and domestic energy consumption from multiple dimensions, and reveals the impact mechanism of the built environment on domestic energy consumption. We find that (1) social and economic conditions are the main factors affecting traffic energy consumption. (2) The population density has a significant negative correlation effect on the energy consumption of transportation trips. When the population density increases by 1%, the energy consumption of total transportation trips, commuting trips, high-energy-consumption trips, and low-energy-consumption trips decreases by 0.094%, 0.115%, 0.273%, and 0.124%, respectively. (3) When the degree of mixed use of land increases by one percentage point, the energy consumption of total transportation trips, commuting trips, high-energy-consumption trips, and low-energy-consumption trips decreases by 0.415%, 0.421%, 2.574%, and 1.197%, respectively. (4) The density of road intersections has a significant negative correlation effect on the energy consumption of traffic trips. (5) The impact of the built environment on the energy consumption of transportation trips is greater than that of residential buildings.
Evolved cataclysmic variables as progenitors of AM CVn stars
Creators: name: Sarkar, Arnab
name: Ge, Hongwei
name: Tout, Christopher A.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We model cataclysmic variables (CVs) with solar metallicity donors ($X=0.7,\:Z=0.02$) that evolve to form AM CVn stars through the Evolved CV formation channel using various angular momentum loss mechanisms by magnetic braking ($\mathrm{AML_{MB}}$). We find that the time-scale for $\mathrm{AML_{MB}}$ in our double-dynamo (DD) model is shorter than that of previously used empirical formulae. Owing to the shorter time-scales, a larger parameter space of initial conditions evolves to form AM CVn stars with the DD model than with other models. We perform an analysis of the expected number of AM CVn stars formed through the Evolved CV channel and find about $3$ times as many AM CVn stars as reported before. We evolve these systems in detail with the Cambridge stellar evolution code (STARS) and show that evolved CVs populate a region with orbital period $P_\mathrm{orb}\geq5.5\,\mathrm{hr}$. We evolve our donors beyond their orbital period minimum and find that a significant number become extremely H-exhausted systems. This makes them indistinguishable from systems evolved from the He-star and the White Dwarf (WD) channels in terms of the absence of H in their spectra. We also compare the masses, mass-transfer rates of the donor, and the orbital period with observations. We find that the state of the donor and the absence of H in systems such as YZ LMi and V396 Hya match with our modelled trajectories, while systems such as CR Boo and HP Lib match with our modelled tracks if their actual donor mass lies on the lower-end of the observed mass range.
description: 15 pages, 15 figures. Accepted for publication in MNRAS
GPU Programming - Speeding Up the 3D Surface Generator VESTA
Creators: name: Schlei, B. R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Graphics (cs.GR)
subject: Computational Geometry (cs.CG)
subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Computer and information sciences

description: The novel "Volume-Enclosing Surface exTraction Algorithm" (VESTA) generates triangular isosurfaces from computed tomography volumetric images and/or three-dimensional (3D) simulation data. Here, we present various benchmarks for GPU-based code implementations of both VESTA and the current state-of-the-art Marching Cubes Algorithm (MCA). One major result of this study is that VESTA runs significantly faster than the MCA.
description: 1 page, 1 figure, submitted contribution to the GSI Scientific Report 2014
Investigating bile acid-mediated cholestatic drug-induced liver injury using a mechanistic model of multidrug resistance protein 3 (MDR3) inhibition
Creators: name: Adiwidjaja, Jeffry
name: Yang, Kyunghee
name: Woodhead, Jeffrey L.
name: Howell, Brett A.
name: Taneja, Guncha
name: Beaudoin, James J.
name: Siler, Scott Q.
name: Watkins, Paul B.
Publisher: name: Frontiers Media S.A.
Year: 2023

description: Inhibition of the canalicular phospholipid floppase multidrug resistance protein 3 (MDR3) has been implicated in cholestatic drug-induced liver injury (DILI), which is clinically characterized by disrupted bile flow and damage to the biliary epithelium. Reduction in phospholipid excretion, as a consequence of MDR3 inhibition, decreases the formation of mixed micelles consisting of bile acids and phospholipids in the bile duct, resulting in a surplus of free bile acids that can damage the bile duct epithelial cells, i.e., cholangiocytes. Cholangiocytes may compensate for biliary increases in bile acid monomers via the cholehepatic shunt pathway or bicarbonate secretion, thereby influencing viability or progression to toxicity. To address the unmet need to predict drug-induced bile duct injury in humans, DILIsym, a quantitative systems toxicology model of DILI, was extended by representing key features of the bile duct, cholangiocyte functionality, bile acid and phospholipid disposition, and cholestatic hepatotoxicity. A virtual, healthy representative subject and population (n = 285) were calibrated and validated utilizing a variety of clinical data. Sensitivity analyses were performed for 1) the cholehepatic shunt pathway, 2) biliary bicarbonate concentrations and 3) modes of MDR3 inhibition. Simulations showed that an increase in shunting may decrease the biliary bile acid burden, but raise the hepatocellular concentrations of bile acids. Elevating the biliary concentration of bicarbonate may decrease bile acid shunting, but increase bile flow rate. In contrast to competitive inhibition, simulations demonstrated that non-competitive and mixed inhibition of MDR3 had a profound impact on phospholipid efflux, elevations in the biliary bile acid-to-phospholipid ratio, cholangiocyte toxicity, and adaptation pathways. The model with its extended bile acid homeostasis representation was furthermore able to predict DILI liability for compounds with previously studied interactions with bile acid transport. The cholestatic liver injury submodel in DILIsym accounts for several processes pertinent to bile duct viability and toxicity and hence, is useful for predictions of MDR3 inhibition-mediated cholestatic DILI in humans.
Towards stability results for global radial basis function based quadrature formulas
Creators: name: Glaubitz, Jan
name: Reeger, Jonah A.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 65D30, 65D32, 65D05, 42C05

description: Quadrature formulas (QFs) based on radial basis functions (RBFs) have become an essential tool for multivariate numerical integration of scattered data. Although numerous works have been published on RBF-QFs, their stability theory can still be considered as underdeveloped. Here, we strive to pave the way towards a more mature stability theory for global and function-independent RBF-QFs. In particular, we prove stability of these for compactly supported RBFs under certain conditions on the shape parameter and the data points. As an alternative to changing the shape parameter, we demonstrate how the least-squares approach can be used to construct stable RBF-QFs by allowing the number of data points used for numerical integration to be larger than the number of centers used to generate the RBF approximation space. Moreover, it is shown that asymptotic stability of many global RBF-QFs is independent of polynomial terms, which are often included in RBF approximations. While our findings provide some novel conditions for stability of global RBF-QFs, the present work also demonstrates that there are still many gaps to fill in future investigations.
description: 28 pages, 11 figures. arXiv admin note: substantial text overlap with arXiv:2108.06375
A RELATIVE STUDY ON THE DECALOGUE OF RONALD KNOX AND THE EARLIER NOVELS IN THE DUBLIN MURDER SQUAD SERIES OF TANA FRENCH
Creators: name: Janani P R, Dr. Preetha C
Publisher: name: Zenodo
Year: 2022
Subjects: Detective, decalogue, fair play, crime, murder, mystery

description: Abstract:  Crime fiction is the mother of mystery and detective fiction, the hard-boiled mode, the police procedural and historical crime fiction. Being the oldest, mystery and detective fiction acquires the absolute quality of crime fiction. This is the only genre of literature that works based on retrograde analysis, a sort of chess game in reverse. The retrograde analysis involves taking a certain position as the starting point and then reconstructing it backwards to work out how it got into that position. The operation of mystery and detective fiction is hinged upon the aforementioned analysis which begins with the result and works backwards to the causes. Mystery and detective fiction have their roots in American Literature and the pioneer in it is Edgar Allen Poe. The development of the corresponding genre is perceived during the times of the great World Wars. The savour of mystery and detective fiction peregrinated overseas and the veterans are also found in World Literature. One such imminent virtuoso of detective fiction is the American novelist, Tana French. This paper foreshadows an affinity between the commandments of Ronald Knox and the selected novels of Tana French.
Business Licencing Reform and Gender Equality: Evidence from Indonesia
Creators: name: Saha, Amrita
name: Megersa, Kelbesa
name: Macdonald, Keir
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Business environment reform targets inadequate business regulations, intending to remove constraints to business investment, enabling growth and job creation, and creating opportunities for international business to contribute to and benefit from this growth. Women-led businesses are likely to be disproportionately negatively affected by a poor business environment. However, there is a dearth of context-specific knowledge of the impact of business environment reform on gender equality. This paper offers new insights into this relationship through an in-depth analysis of the Pelayanan Terpadu Satu Pintu (PTSP) or one-stop shop business licencing reform in 2009, exploiting the variation in the extent of its implementation to examine how the effects vary, focussing on the gender of firm leadership. Our findings suggest that the reform is unlikely to have led to either unintended negative consequences for women-led firms, nor do we find any evidence of transformational change. Outside Jakarta, advances for women were achieved, while in Jakarta existing exclusions were maintained and arguably deepened. Stronger gender and inclusion outcomes would require further deepening and expanding the positive achievements identified, including general business environment improvements coupled with targeted support for sectors.
An optical particle size spectrometer for aircraft-borne measurements in IAGOS-CARIBIC
Creators: name: Hermann, Markus
name: Weigelt, Andreas
name: Assmann, Denise
name: Pfeifer, Sascha
name: Müller, Thomas
name: Conrath, Thomas
name: Voigtländer, Jens
name: Heintzenberg, Jost
name: Wiedensohler, Alfred
name: Martinsson, Bengt G.
name: Deshler, Terry
name: Brenninkmeijer, Carl A.M.
name: Zahn, Andreas
Publisher: name: München : European Geopyhsical Union
Year: 2016
Subjects: subject: aerosol
subject: airborne survey
subject: climate change
subject: data acquisition
subject: EOS
subject: optical property
subject: particle size
subject: sensor
subject: size distribution
subject: spectrometer
subject: stratosphere
subject: tropopause
subject: 550

description: The particle number size distribution is an important parameter to characterize the atmospheric aerosol and its influence on the Earth's climate. Here we describe a new optical particle size spectrometer (OPSS) for measurements of the accumulation mode particle number size distribution in the tropopause region on board a passenger aircraft (IAGOS-CARIBIC observatory: In-service Aircraft for a Global Observing System – Civil Aircraft for Regular Investigation of the Atmosphere Based on an Instrument Container). A modified KS93 particle sensor from RION Co., Ltd., together with a new airflow system and a dedicated data acquisition system, is the key component of the CARIBIC OPSS. The instrument records individual particle pulse signal curves in the particle size range 130–1110 nm diameter (for a particle refractive index of 1.47-i0.006) together with a time stamp and thus allows the post-flight choice of the time resolution and the size distribution bin width. The CARIBIC OPSS has a 50 % particle detection diameter of 152 nm and a maximum asymptotic counting efficiency of 98 %. The instrument's measurement performance shows no pressure dependency and no particle coincidence for free tropospheric conditions. The size response function of the CARIBIC OPSS was obtained by a polystyrene latex calibration in combination with model calculations. Particle number size distributions measured with the new OPSS in the lowermost stratosphere agreed within a factor of 2 in concentration with balloon-borne measurements over western North America. Since June 2010 the CARIBIC OPSS is deployed once per month in the IAGOS-CARIBIC observatory.
title: Histopathological correlation with Magnetic Resonance (MR) Imaging from MR-simulator and MR-Linac in Oesophageal and Gastric Cancers
Creators: name: Fong, Su Chen
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2023
Subjects: subject: Gastrointestinal tract
subject: MR
subject: Radiation therapy / Oncology
subject: Cancer
subject: Other

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: The implementation of MR-sim and MR-linac in Radiation Oncology has been driven by the unique advantages of magnetic resonance imaging (MRI) such as excellent soft tissue contrast, biomarkers information, motion assessment and lack of ionising...
Additional file 12 of Health Benefits of Different Sports: a Systematic Review and Meta-Analysis of Longitudinal and Intervention Studies Including 2.6 Million Adult Participants
Creators: name: Oja, Pekka
name: Memon, Aamir Raoof
name: Titze, Sylvia
name: Jurakic, Danijel
name: Chen, Si-Tong
name: Shrestha, Nipun
name: Em, Sowannry
name: Matolic, Tena
name: Vasankari, Tommi
name: Heinonen, Ari
name: Grgic, Jozo
name: Koski, Pasi
name: Kokko, Sami
name: Kelly, Paul
name: Foster, Charlie
name: Podnar, Hrvoje
name: Pedisic, Zeljko
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Cancer
Science Policy

description: Additional file 12: The longitudinal associations between cycling and the risk of mortality and morbidity: results of 5 sensitivity meta-analyses of hazard ratios for any participation or the highest reported dose of activity.
Core global metrics of chronic kidney disease (CKD) prevalence in the GBD 2019 Study
Creators: name: Boris, Bikbov
Publisher: name: Zenodo
Year: 2023
Subjects: kidney
Global Health
Public Health
chronic kidney disease
impaired kidney function
CKD
Global Burden of Disease Study
GBD
epidemiology
morbidity
prevalence

description: Chronic kidney disease (CKD) is an important contributor to morbidity and mortality from noncommunicable diseases, and is highly relevant topic in global health. The Global Burden of Disease, Injuries and Risk Factors (GBD) study presents a comprehensive assessment of the global epidemiology of CKD both as a direct cause of mortality and morbidity and as a risk factor for other diseases. The GBD uses term "impaired kidney function (IKF)" to indicate the CKD as a risk factor for ischaemic heart disease, stroke, peripheral vascular disease, and gout, and underline the difference from the term "CKD" itself that refers to a direct cause of morbidity and mortality due to kidney disease. Scientific-Tools.Org created a series of infographics highlighting different aspects of CKD epidemiology at global, regional and country levels. This work is licensed under a Creative Commons Attribution NoDerivatives License. See other infographics on CKD epidemiology: https://scientific-tools.org/portfolio-item/infographics-on-chronic-kidney-disease-ckd-epidemiology