cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Decreased Host-Cell ATP Levels Affects Bacteriophage Replication in Knockout E. coli Strains
Creators: name: Alumyar, Marrie
name: Beitzell, Lauren
name: Bradish, Kristin
name: Kato, Rion
name: Vozna, Alina
Publisher: name: Digital Repository at the University of Maryland
Year: 2024
Subjects: subject: FIRE
subject: Microbiology
subject: FOS: Biological sciences
subject: Virology
subject: Biological Sciences

description: Bacteriophages are viruses that use host cell metabolic resources for replication. Altering Escherichia coli's ATP production pathway can inhibit bacteriophage replication, offering a new approach to bacteriophage therapy.The atp genes encode ATP synthase subunits crucial for ATP generation in E. coli. Knockouts ΔatpA, B, D, E, and H, alongside the parent strain, were studied. Focus narrowed to ΔatpA and B due to significant deviations from the parent strain. It is hypothesized that these knockout strains reduce growth in E. coli and bacteriophage due to decreased ATP production, vital for metabolism and phage replication. Comparative growth assays of E. coli parent and ATP knockout strains were conducted in LB-rich media and M9 minimal media. T4 bacteriophage replication was measured through lysis curves, plaque assays, and two time-point phage titer experiments, chosen for consistent replication. Characterization of T4 bacteriophage replication revealed ΔatpA's crucial role, showing difficulties in growth and lysing. ΔatpA required 10-4 dilutions in phage titer experiments due to low PFU/mL, contrasting with 10-7 dilutions for other strains. ATP assay data showed significantly lower ATP concentration (319nM) in ΔatpB compared to the parent strain, also implying its crucial role in ATP synthesis.Future research will focus on characterizing phage replication in ATP synthase knockout strains using E. coli ATP synthase inhibitors to deepen understanding of phage-host interactions. Controlled bacteriophage manipulation can be studied further to have a better understanding of the application of bacteriophage therapy and to potentially improve its clinical efficacy.
A COLORIMETRIC METHOD FOR QUANTIFICATION OF OXIDATIVE DAMAGE TO DNA USING ELISA-LIKE ASSAY.
Creators: name: Upadhyay, Sudesh
Publisher: name: Maryland Shared Open Access Repository
Year: 2006

description: DNA damage induced by reactive oxygen species has attracted considerable interest in recent years and has generated extensive discussion on the relevance of spontaneous DNA damage to aging and to cancer in humans. Although several methods have been used to measure the amount of DNA damage, they are either laborious, use radioactivity or are hard to replicate. A better candidate for an easy and sensitive way to detect DNA damage is a novel reagent prepared by reacting 0- (carboxymethyl)hydroxylamine with biotin hydrazide in the presence of carbodimide. The product of this reaction is a reagent called Aldehyde Reactive Probe (ARP). One of the many damages from reactive oxygen species due to attack by hydroxyl radical on the deoxyribose moiety is a base loss in the form of an apurinic (AP site). During Enzyme immunoassay, the ARP reagent acts as a bridge as it tags the damaged DNA molecule's AP site through its amino terminal and the enzyme through its avidin/biotin complex. The number of AP sites can then be determined by biotin/avidin system followed by enzymatic colorimetric detection. This system can measure the number of AP sites as low as 1 AP/10⁵ base pairs.
Development of New Business Models: Introducing the Cultural Elasticity Model
Creators: name: Byrge, Christian
name: Drejer, Anders
name: Lyndgaard, Danielle Bjerre
name: Lassen, Hanne Merete
Publisher: name: Journal of Business Models
Year: 2019

description: The paper presents the Cultural Elasticity Model as a new perspective on how existing companies may better perform continuous organic development of business models. It suggests three organisational pillars for the development of an organisation with strong cultural elasticity and therefore the ability to better innovate new business models.
description: Journal of Business Models, Vol 7 No 4 (2019): Journal of Business Model, Special Issue, Conference 2019
Influence of the Tachocline on Solar Evolution
Creators: name: Brun, A. S.
name: Zahn, J. P.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Recently helioseismic observations have revealed the presence of a shear layer at the base of the convective zone related to the transition from differential rotation in the convection zone to almost uniform rotation in the radiative interior, the tachocline. At present, this layer extends only over a few percent of the solar radius and no definitive explanations have been given for this thiness. Following Spiegel and Zahn (1992, Astron. Astrophys.), who invoke anisotropic turbulence to stop the spread of the tachocline deeper in the radiative zone as the Sun evolves, we give some justifications for their hypothesis by taking into account recent results on rotating shear instability (Richard and Zahn 1999, Astron. Astrophys.). We study the impact of the macroscopic motions present in this layer on the Sun's structure and evolution by introducing a macroscopic diffusivity $D_T$ in updated solar models. We find that a time dependent treatment of the tachocline significantly improves the agreement between computed and observed surface chemical species, such as the $^7$Li and modify the internal structure of the Sun (Brun, Turck-Chièze and Zahn, 1999, in Astrophys. J.).
description: to appear in Annals of the New York Academy of Sciences, vol 898. Postscript file, 9 pages and 5 figures New Email Address for A. S. Brun: sabrun@solarz.colorado.edu
The New Media Business Model: When Customer Controls the Data
Creators: name: Novikova, Olga
Publisher: name: Journal of Business Models
Year: 2019

description: The EU General Data Protection Regulation (GDPR) is the first step in the process of transferring data ownership back to the customers. This regulation brings major changes for any organization working with consumers and their data, or processing data about individuals in the context of selling goods or services to the citizens. This paper considers the case of a media company offering online content and discusses what implications data ownership by the customers have for the media company’s business model.
description: Journal of Business Models, Vol 7 No 4 (2019): Journal of Business Model, Special Issue, Conference 2019
Dependable Perception for Robots
Creators: name: Thorpe, Chuck
name: Clatz, Olivier
name: Duggins, David
name: Gowdy, Jay
name: MacLachlan, Rob
name: J. Ryan  Miller
name: Mertz, Christoph
name: Siegel, Mel
name: Chieh-Chih  Wang
name: Yata, Teruko
Publisher: name: Carnegie Mellon University
Year: 2001
Subjects: subject: 80101 Adaptive Agents and Intelligent Robotics
subject: FOS: Computer and information sciences

description: The weakest link in many mobile robots is perception. In order to build robots that are reliable and dependable and safe, we need to build robots that can see. Perception is becoming a solved problem for certain constrained environments. But for robots working outdoors, and at high speeds, and in close proximity to people, perception is still incomplete. Our robots need to see objects; to detect motion; and to detect which of those objects are people. In the current state of the art, this requires multiple sensors and multiple means of interpretation. This paper illustrates those principles in the context of the CMU Navlab Group's work on vehicle safety for busses and passenger cars.
Business Model Performance: Paving the road for comparable data on business models
Creators: name: Thomsen, Peter
Publisher: name: Journal of Business Models
Year: 2019

description: Attempting to close the gap of missing available quantitative data on business models, we identify value creation patterns, which may be interpreted as personality tests of companies’ value creation. It is our intention to explain the notion of using value drivers to create links between different business models and performance measurement.
description: Journal of Business Models, Vol 7 No 4 (2019): Journal of Business Model, Special Issue, Conference 2019
Additional file 1 of Mid-term (up to 12 years) clinical and echocardiographic outcomes of percutaneous transvenous mitral commissurotomy in patients with rheumatic mitral stenosis
Creators: name: Dadjo, Yahya
name: Moshkani Farahani, Maryam
name: Nowshad, Reza
name: Sadeghi Ghahrodi, Mohsen
name: Moaref, Alireza
name: Kojuri, Javad
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy

description: Additional file 1. Strobe checklist of patient enrollement.
Nuclear-to-Outer Rotation Curves of Galaxies in the CO and HI Lines
Creators: name: Sofue, Yoshiaki
Publisher: name: arXiv
Year: 1996
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We have derived rotation curves of nearby galaxies, which are almost completely sampled from the inner to outer regions. We used high-resolution position-velocity diagrams in the CO line along the major axes for the inner regions, and HI-line data for the outer regions. We combined the CO and HI data to obtain total rotation curves from the nuclear to outer regions. The rotation curves show a steep nuclear rise within a radius smaller than the resolutions of CO-line observations, indicating a compact massive concentration near the nucleus. We show that the nuclear steep rise is general and universal, and a rigid body-like gentle rise is exceptional. Keywords: Galaxies: kinematics - Galaxies: rotation - Galaxies: structure - Galaxies: general - ISM: CO emission - ISM: HI gas
description: To appear in PASJ vol.49, No.1, 1997, Plain TeX
title: ADCO, Cartulaire de Fontenay, second fragment (XIIIe siècle), Cart. 201 (15 H 9), folios 47-142, f. 032r
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2009
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire

description: Cartulaire de Fontenay, second fragment (XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 201 (15 H 9), folios 47-142. Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Fontenay, second fragment (XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 201 (15 H 9), folios 47-142, f. 032r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Fontenay
description: Provenance: http://www.wikidata.org/entity/Q464918
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb119679755
description: Provenance: https://www.geonames.org/7874015
description: Provenance: http://www.idref.fr/027691802/id
Future Spin Physics at JLab; 12 GeV and Beyond
Creators: name: de Jager, Kees
Publisher: name: arXiv
Year: 2006
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The project to upgrade the CEBAF accelerator at Jefferson Lab to 12 GeV is presented. Most of the research program supporting that upgrade, will require a highly polarized beam, as will be illustrated by a few selected examples. To carry out that research program will require an extensively upgraded instrumentation in two of the existing experimental halls and the addition of a fourth hall. The plans for a high-luminosity electron-ion collider are briefly discussed.
description: 6 pages; 2 figures; submitted to the Proceedings of SPIN2006
Public Opinion on Scientists’ Role In Policymaking: A Data Analysis
Creators: name: Sanghavi, Mahi
name: Bhutani, Arshnoor
Publisher: name: Digital Repository at the University of Maryland
Year: 2024

description: From climate change to healthcare, there are a myriad of public policies that relate to scientific fields in the United States. Policymakers rely on scientific data and research to write these policies, but there is debate on if these policies match the people’s desires and are altruistic. In our research, we will understand the public’s opinion on medical scientists and scientists acting in the public’s best interests, and analyze how this impacts the public’s opinion on scientific experts in making policy decisions. In order to accomplish this, we are referencing a dataset that details a survey questionnaire designed by a Pew Research Study aimed at understanding how Americans perceive science and gauge their levels of confidence in science and medical scientists. By using R’s polr package to execute an ordinal logistic regression, we can determine the relationship between the public’s confidence in medical scientists and scientists as well as the public’s confidence in scientific expert’s abilities to make policy decisions. Our next steps will be to run this regression model, and the findings obtained by running this regression will show how the explanatory variables impact the level of confidence in the ordinal variable. By leveraging the results from our statistical analysis, policymakers can gain insight on if the public prefers them working in conjunction with scientists, and increasing a scientist’s role in policymaking, or if only scientific facts should be used. Ultimately, this research works to boost public trust in the scientific field and the policies that are passed.
title: Les Anglophones à Pau : Transcription interview with Lisa Anon2A
Creators: name: Milne, Andrew
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: Integration
subject: Identity
subject: Canadian
subject: Language learning
subject: Migration
valueUri: http://id.loc.gov/authorities/subjects/sh00005935
subject: Roots
valueUri: http://id.loc.gov/authorities/subjects/sh00007663
subject: Travelling

description: Migratory trajectory and oral history of English-speakers in the city of Pau
The Local Interstellar Medium in Puppis-Vela
Creators: name: Cha, A.
name: Sahu, M.
name: Moos, H. W.
name: Blaauw, A.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The first study of the local interstellar medium (LISM) toward Puppis-Vela (l = 245\degr to 275\degr, b = -15\degr to +5\degr, d < 200 pc) is presented in this paper. A study of the locations, sizes, and physical characteristics of local interstellar gas, i.e. ``astronephography,'' is included, and relies upon the improved distance measurements provided by Hipparcos parallax measurements. All spectra of more distant sight lines contain absorption features due to intervening local gas, and more distant structures can only be studied accurately if components due to the LISM have been isolated. Towards this end, high resolution (R ~ 95,000), high signal-to-noise (S/N ~ 110 to 250) Na I spectra of 11 nearby stars in the direction of Puppis-Vela have been obtained. Toward Puppis-Vela, absorption due to the LIC was not observed, but components at three distinct velocities were found, and the extent of the local gas producing the features was estimated. The conclusions regarding the UV spectrum of gamma^2 Vel presented by Fitzpatrick & Spitzer (1994) were re-examined in light of this new LISM data, and the ambiguity in their conclusions about several absorption components is resolved. The stars in Puppis-Vela flank the region of the apparent extension of the Local Bubble (or Cavity) known as the beta CMa tunnel,and measurements of the Na I column density towards the sample stars have been used to modify existing estimates of the extent of the tunnel. A compilation of all existing Na I observations of < 200 pc sight lines around the tunnel reveal that low column densities have been exclusively detected within l ~ 210\degr to 250\degr,and b ~ -21\degr to -9\degr. Near the Galactic plane,at latitudes -10\degr < b < 0\degr and d ~< 150 pc, the tunnel is confined to l < 270\degr, a lower longitude than was previously reported.
description: 18 pages plus 7 figures and 9 tables. To appear in ApJS
Testing CPS with Design Assumptions-Based Metamorphic Relations and Genetic Programming
Creators: name: Mandrioli, Claudio
name: Shin, Seung Yeob
name: Bianculli, Domenico
name: Briand, Lionel
Publisher: name: arXiv
Year: 2024
Subjects: subject: Software Engineering (cs.SE)
subject: Systems and Control (eess.SY)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Cyber-Physical Systems (CPSs) software is used to enforce desired behaviours on physical systems. To test the interaction between the CPS software and the system's physics, engineers provide traces of desired physical states and observe traces of the actual physical states. CPS requirements describe how closely the actual physical traces should track the desired traces. These requirements are typically defined for specific, simple input traces such as step or ramp sequences, and thus are not applicable to arbitrary inputs. This limits the availability of oracles for CPSs. Our recent work proposes an approach to testing CPS using control-theoretical design assumptions instead of requirements. This approach circumvents the oracle problem by leveraging the control-theoretical guarantees that are provided when the design assumptions are satisfied. To address the test case generation and oracle problems, researchers have proposed metamorphic testing, which is based on the study of relations across tests, i.e., metamorphic relations (MRs). In this work, we define MRs based on the design assumptions and explore combinations of these MRs using genetic programming to generate CPS test cases. This enables the generation of CPS input traces with potentially arbitrary shapes, together with associated expected output traces. We use the deviation from the expected output traces to guide the generation of input traces that falsify the MRs. Our experiment results show that the MR-falsification provides engineers with new information, helping them identify passed and failed test cases. Furthermore, we show that the generation of traces that falsify the MRs is a non-trivial problem, which is successfully addressed by our genetic search.
GH45 gene tree including all coorthologs
Creators: name: Muelbaier, Hannah
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 310208
subject: Translational and applied bioinformatics
classificationCode: 310203
subject: Computational ecology and phylogenetics
classificationCode: 310299
subject: Bioinformatics and computational biology not elsewhere classified

description: GH45 cellulase gene tree of all detected GH45 cellulase co-orthologs Newick format
STRUCTURE AND METAMORPHIC ANALYSIS OF WEYTO AREA, SOUTHWESTERN ETHIOPIA
Creators: name: GEZAHEGN ABIY WORKNEH
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2019
Subjects: Brittle structure, Deformation, Drag-folds, Ductile structure, Metamorphism, Tight-isoclinal fold

description: The Weyto area lies within the Southwestern Ethiopian shield. Field geological mapping at scale of 1:50,000 and augmented with petrographic analysis, digital elevation model and google earth images are used to study the lithological distribution, deformation history and metamorphic features of the area covering 90 km2 around Weyto town. The result of the data shows that the area is covered by high-grade Precambrian metamorphic rocks, with minor Cenozoic volcanic rock and rift basin filling unconsolidated sediments. The area has experienced four phases of Precambrian ductile deformations (D1-D4) and a Cenozoic brittle deformation (D5). The first two deformational phases (D1 and D2) are progressive shortening deformation and produced major N-S trending composite regional foliations. The metamorphic minerals defining the S2 fabric are characteristic of upper amphibolite facies and suggest that peak metamorphism (M1) has attained during the D2 event. D3 is characterized by northsouth sinistral shearing produces north-south tight drag-folds with S3 shear fabrics defined by retrograde metamorphic minerals of upper greenschist facies (M2). D4 deformation locally produces a weak east-west trending open upright folds (F4) with no recorded axial planar fabric. D5 deformation is associated with the extensional deformation which produced the East African Rift System. It is characterized by northsouth trending normal faults and joints in the study area and produced a series of grabens and horsts; here termed the Buraele Graben, the Weyto Graben and the Guyle Horst. The faults have varied magnitude of throws along the strike of individual faults. The down throw reaches up to 600m when the fault plane is parallel to the Precambrian ductile structure and minimal when the faults dip opposite to the Precambrian structures indicative of the control of Tertiary rift faulting by the Precambrian structural grain.
Additional file 1 of Variants in a cis-regulatory element of TBX1 in conotruncal heart defect patients impair GATA6-mediated transactivation
Creators: name: Jiang, Xuechao
name: Li, Tingting
name: Liu, Sijie
name: Fu, Qihua
name: Li, Fen
name: Chen, Sun
name: Sun, Kun
name: Xu, Rang
name: Xu, Yuejuan
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1. Fig. S1 Deletion analysis identifies a 0.65-kb region around the TBX1 TSS essential for transcriptional activity in the NIH/3T3 cell line. Fig. S2 UCSC Genome Browser views of cCREs around the TBX1 TSS and the underlying DNase and ChIP data (hg38 human genomes). Fig. S3 Verification of in vitro-translated GATA6 by reticulocyte lysates.
Denoising Manifold and Non-Manifold Point Clouds
Creators: name: Unnikrishnan, Ranjith
name: Hebert, Martial
Publisher: name: Carnegie Mellon University
Year: 2007
Subjects: subject: 80101 Adaptive Agents and Intelligent Robotics
subject: FOS: Computer and information sciences

description: The faithful reconstruction of 3-D models from irregular and noisy point samples is a task central to many applications of computer vision and graphics. We present an approach to denoising that naturally handles intersections of manifolds, thus preserving high-frequency details without oversmoothing. This is accomplished through the use of a modified locally weighted regression algorithm that models a neighborhood of points as an implicit product of linear subspaces. By posing the problem as one of energy minimization subject to constraints on the coefficients of a higher order polynomial, we can also incorporate anisotropic error models appropriate for data acquired with a range sensor. We demonstrate the effectiveness of our approach through some preliminary results in denoising synthetic data in 2-D and 3-D domains.
On the Uncertainties of the Central Density in Axisymmetric Galaxies due to Deprojection
Creators: name: Bosch, Frank C. van den
Publisher: name: arXiv
Year: 1996
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The deprojection of the surface brightness of axisymmetric galaxies is indeterminate unless the galaxy is seen edge-on. In practice, this problem is often circumvented by making ad hoc assumptions about the density distribution. However, one can redistribute the density and still project to the same surface brightness. This is similar to adding so-called konus densities to the assumed density distribution. In this paper we investigate the maximum konus density that one can add to elliptical galaxies. In particular we focus on the uncertainties in the central densities of axisymmetric, (cusped) elliptical galaxies due to the non-uniqueness of the deprojection. In order to estimate the dynamical influence of konus densities on the central region, we calculate the mass fraction they can add to the center. We show that this mass fraction is at most a few percent. We also investigate the dynamical effect of cusped konus densities We show that konus densities can only be moderately cusped, and that an increase in cusp slope results in a decrease of the mass fraction added to the center by the konus density. We illustrate all this by the specific example of M32, and show that the uncertainty in the central mass due to deprojection is negligible compared to the inferred mass of the central black hole (BH) in this galaxy.
description: Accepted for publication in MNRAS. Tex, 14 pages, including 16 figures
Towards a new paradigm for heavy-light meson spectroscopy
Creators: name: Du, Meng-Lin
name: Albaladejo, Miguel
name: Fernandez-Soler, Pedro
name: Guo, Feng-Kun
name: Hanhart, Christoph
name: Meißner, Ulf-G.
name: Nieves, Juan
name: Yao, De-Liang
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Lattice (hep-lat)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Since 2003 many new hadrons, including the lowest-lying positive-parity charm-strange mesons ${D_{s0}^*(2317)}$ and ${D_{s1}(2460)}$, were observed that do not conform with quark model expectations. It was recently demonstrated that various puzzles in the charm meson spectrum find a natural resolution, if the SU(3) multiplets for the lightest scalar and axial-vector states, amongst them the ${D_{s0}^*(2317)}$ and the ${D_{s1}(2460)}$, owe their existence to the nonperturbative dynamics of Goldstone-Boson scattering off $D_{(s)}$ and $D^*_{(s)}$ mesons. Most importantly the ordering of the lightest strange and nonstrange scalars becomes natural. In this work we demonstrate for the first time that this mechanism is strongly supported by the recent high quality data on the ${B^-\to D^+π^-π^- }$ provided by the LHCb experiment. This implies that the lowest quark-model positive-parity charm mesons, together with their bottom counterparts, if realized in nature, do not form the ground-state multiplet. This is similar to the pattern that has been established for the scalar mesons made from light up, down and strange quarks, where the lowest multiplet is considered to be made of states not described by the quark model. In a broader view, the hadron spectrum must be viewed as more than a collection of quark model states.
description: 8 pages, 5 figures. Discussion significantly extended, suggestion for lattice and more comparison with LHCb data added; version accepted for publication in PRD
Anglophones in Pau: Transcription Interview Lisa Anon2B
Creators: name: Milne, Andrew
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024

description: Migratory Trajectory and Oral History of English-Speakers in the city of Pau
MUCOSAL IMMUNIZATION AGAINST PLAGUE
Creators: name: Van Meter, Chad J.
Publisher: name: Maryland Shared Open Access Repository
Year: 1999

description: Yersinia pestis is the causative agent of plague. There are two forms of the disease, the bubonic and the pneumonic form. The bubonic form can be acquired by humans from the bite of an infected flea which can lead to the pneumonic form where aerosol transmission between humans is highly fatal. There are two vaccines (USP and EV76) currently in use throughout the world and both have serious limitations. The USP vaccine is a formalin-killed whole-cell preparation. Unfortunately this vaccine does not seem to protect against the pneumonic form of the disease. The EV76 preparation is a live attenuated vaccine which has been associated with high reactogenicity. The Low Calcium Response Virulence (LcrV) antigen of Y. pestis is a promising candidate antigen. In this study the LcrV antigen was genetically fused to the N-terminus of cholera toxin A subunit (CtxA) (MTD672) or to the A2 peptide of CtxA (MTD669). These fusion proteins were co-expressed with the B subunit of cholera toxin (CtxB) in Escherichia coli to form a functional chimeric holotoxin. The resulting holotoxins were purified and characterized. Both chimeras retained their ability to bind to Gm ganglioside and to cross react with polyclonal antiserum to LcrV and to Ctx. The chimeras were assessed for their immunogenicity in mice by both the intraperitoneal and intranasal routes of immunization. The results indicate that the chimeras were able to elicit IgG antibody in the serum and the lung by both routes of immunization. Attempts to assess the ability of these vaccine candidates to protect mice against aerosol challenge with Y. pestis were thwarted by the failure of the positive control group to survive challenge.
title: ADCO, Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.1 (début XIIIe siècle), Cart. 166 (11 H 64), 136 folios, f. 0003v
Creators: name: de la Côte d'Or, Archives départementales
name: CG21/F.PETOT/2012
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.1 (début XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 166 (11 H 64), 136 folios, f. 0003v, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.1 (début XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 166 (11 H 64), 136 folios, f. 0003v, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: abbaye de Cîteaux
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Nucleon Form Factor Experiments and the Pion Cloud
Creators: name: de Jager, Kees
Publisher: name: arXiv
Year: 2006
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The experimental and theoretical status of elastic electron scattering from the nucleon is reviewed. A wealth of new data of unprecedented precision, especially at small values of the momentum transfer, in parallel to new theoretical insights, has allowed sensitive tests of the influence of the pionic cloud surrounding the nucleon.
description: 9 pages; 4 figures; submitted to the Proceedings of the Shape of the Nucleon
Additional file 1 of The impact of out-of pocket payments of households for dental healthcare services on catastrophic healthcare expenditure in Iran
Creators: name: Woldemichael, Abraha
name: Rezaei, Satar
name: Kazemi Karyani, Ali
name: Ebrahimi, Mohammad
name: Soltani, Shahin
name: Aghaei, Abbas
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1.
Characterization of mussel shells as a bio-based building insulation material
Creators: name: Martínez-García, C.
name: González-Fonteboa, B.
name: Carro-López, D.
name: Martínez-Abella, F.
name: Pérez Ordóñez, J. L.
Publisher: name: Academic Journal of Civil Engineering
Year: 2019

description: In Galicia, 35% of mussel culture is intended for canning. This industry has 25 thousand tons per year of waste (i.e., shells) that mainly ends in landfills or at the bottom of the sea, thereby producing an important environmental impact. After performing a heat treatment, mussel shells become a by-product which is suitable for different uses (poultry feed or bed, soil acidity correction, and fertilizer). However, a minority output and other avenues target related to this by-product must still be explored. Building insulation materials commonly cause significant harmful effect on the environment, especially if their entire life cycle is analysed (the use of large amounts of energy and water for their production, the difficulty to be recycled, or the reuse of waste in the case of demolition or reform, etc.) The use of mussels could close the circle of the economy related to the canning industry in Galicia. The aim of this research is to prove the feasibility of mussel shells as a part of building solutions. Suitable thermal and acoustical characteristics of shells as a building insulation material have been found. The confined mussel shell inside a closed space (e.g., in a wooden box) has a thermal transmittance similar to an expanded clay or a light conifer wood, so it can be considered as a material of low thermal conductivity. Moreover, several acoustic studies indicate that a section of confined mussel shell presents a behaviour similar to a double-glazed window. Different building solutions have been designed using shells as a filling insulation material. First, they were tested in a laboratory and then in an experimental building of 60 square meters (Biovalvo Modulus). These modulus mussel shells were used in the roof, the walls and the foundation. Nearly 50 tons of treated mussel shells were converted into a useful by-product which was used as a bio-based building material.
description: Academic Journal of Civil Engineering, Vol 37 No 2 (2019): Special Issue - ICBBM 2019
Deformable Graph Matching
Creators: name: Zhou, Feng
name: Torre, Fernando De La
Publisher: name: Carnegie Mellon University
Year: 2013
Subjects: subject: 80101 Adaptive Agents and Intelligent Robotics
subject: FOS: Computer and information sciences

description: Graph matching (GM) is a fundamental problem in computer science, and it has been successfully applied to many problems in computer vision. Although widely used, existing GM algorithms cannot incorporate global consistence among nodes, which is a natural constraint in computer vision problems. This paper proposes deformable graph matching (DGM), an extension of GM for matching graphs subject to global rigid and non-rigid geometric constraints. The key idea of this work is a new factorization of the pair-wise affinity matrix. This factorization decouples the affinity matrix into the local structure of each graph and the pair-wise affinity edges. Besides the ability to incorporate global geometric transformations, this factorization offers three more benefits. First, there is no need to compute the costly (in space and time) pair-wise affinity matrix. Second, it provides a unified view of many GM methods and extends the standard iterative closest point algorithm. Third, it allows to use the path-following optimization algorithm that leads to improved optimization strategies and matching performance. Experimental results on synthetic and real databases illustrate how DGM outperforms state-of-the-art algorithms for GM. The code is available at http://humansensing.cs.cmu.edu/fgm
Anglophones in Pau: Transcription Interview Pascal Jones
Creators: name: Milne, Andrew
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024

description: Migratory Trajectory and Oral History of English-Speakers in the city of Pau
Theoretical Review of B-physics
Creators: name: Martinelli, G.
Publisher: name: arXiv
Year: 1996
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Weak decays and mixing of B-hadrons play a special role in our understanding of the physics of the Standard Model and beyond. The measured amplitudes, however, result from a complicated interplay of weak and strong interaction effects. Understanding strong interaction dynamics, which becomes simpler for heavy quarks, is thus a fundamental part of the game. In this review, several theoretical aspects of B dynamics which are relevant for current and future experimental measurements are discussed.
description: LaTeX, 27 pages, 5 figures. Summary talk given at BEAUTY 96, June 17-21 1996, Rome (Italy), to appear in the Proceedings
THE ROLE OF Tp53 IN THE FORMATION OF Ras INDUCED SQUAMOUS CELL CARCINOMAS
Creators: name: Vitale-Cross, Lynn A.
Publisher: name: Maryland Shared Open Access Repository
Year: 2008

description: To increase our understanding of the nature of the genetic events leading to cancer formation, we have investigated the role of the Tp53 tumor suppressor gene in the progression of Ras-induced squamous cell carcinomas (SCC) by the use of complementary chemically-induced and genetically-defined mouse models. These models include the classic 2-hit chemical carcinogenesis model, and the targeted expression in stratified epithelium of a mutated form of K-Ras using a tetracycline- inducible system or a tamoxifen-inducible Cre-recombinase system in Tp53 wild-type, heterozygous, and conditional double knockout mice. Overall, we conclude that Ras activation and Tp53 inactivation are sufficient to initiate SCC in the oral epithelium, but that additional events are necessary to promote skin SCC. We also provide evidence that Ras activation and overexpression, such as by gene amplification, in a cell population that includes the epithelial stem cells is sufficient to initiate SCC progression, thus overriding the requirement for Tp53 inactivation.
Definition, determination and characterization of acceleration sets for spatial manipulators
Creators: name: Yong-Yil  Kim
name: Desa, Subhas
Publisher: name: Carnegie Mellon University
Year: 1989
Subjects: subject: 80101 Adaptive Agents and Intelligent Robotics
subject: FOS: Computer and information sciences

description: Abstract: "In this report the approach developed by the authors, for systematically studying the acceleration capabilites and acceleration properties of the end-effector of a planar 2 degree-of-freedom manipulator, is extended to the general spatial manipulator with three degrees-of-freedom. A central feature of this report is the determination of the properties of the quadratic mapping between the "joint-velocity" space and the acceleration space of P which then makes it possible to obtain analytical solutions for most acceleration properties of interest. We show that a fundamental way of studying these quadratic mappings is in terms of the mapping of (input) line congruences into (output) line congruences."
Preferred traces on C*-algebras of self-similar groupoids arising as fixed points
Creators: name: Claramunt, Joan
name: Sims, Aidan
Publisher: name: arXiv
Year: 2017
Subjects: subject: Operator Algebras (math.OA)
subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 46L05

description: Recent results of Laca, Raeburn, Ramagge and Whittaker show that any self-similar action of a groupoid on a graph determines a 1-parameter family of self-mappings of the trace space of the groupoid C*-algebra. We investigate the fixed points for these self-mappings, under the same hypotheses that Laca et al. used to prove that the C*-algebra of the self-similar action admits a unique KMS state. We prove that for any value of the parameter, the associated self-mapping admits a unique fixed point, which is in fact a universal attractor. This fixed point is precisely the trace that extends to a KMS state on the C*-algebra of the self-similar action.
description: 12 pages; v2: this version matches the published version
Properties of concrete made of fine aggregates partially replaced by incinerated municipal solid waste bottom ash
Creators: name: Baalbaki, O.
name: Elkordi, A.
name: Ghanem, H.
name: Machaka, M.
name: Khatib, J. M.
Publisher: name: Academic Journal of Civil Engineering
Year: 2019

description: The objectives of this research is to investigate the influence of Municipal Solid Waste Incinerated Bottom Ashes (MSWI-BA) on engineering properties of specimens when part of fine aggregate is replaced with it. Disposal of municipal wastes is a major key issue which causes a problematic challenge in Lebanon as landfill space for the disposal of ash from Municipal Solid Waste Incineration (MSWI) becomes rare. It becomes smarter to reduce the volume of materials being disposed. Recycling is one approach, waste minimization is the second, and combustion for energy production is the third. Therefore, one of the possibilities that have a beneficial impact on the environment and consequently on the society is to use Municipal Solid Waste Incineration (MSWI) ashes in concrete production, as it is done with coal combustion products. The bottom ash features the most convenient composition for this purpose as it is available in highest amounts among the MSWI ashes. Bottom ash can be used as partial replacement of sand in concrete. This has the additional advantage of replacing sand and gravel, which must be mined sometimes from environmentally sensitive areas. The properties of concrete with partial substitution of sand by bottom ash up to 50% was investigated in terms of compressive strength, pulse velocity, capillary and total absorption. The bottom ash incorporated in the concrete behaves almost like ordinary sand. These results indicates that the use of waste in concrete constitutes a potential means of adding value and at the same time reduce greenhouse gases.
description: Academic Journal of Civil Engineering, Vol 37 No 2 (2019): Special Issue - ICBBM 2019
Anglophones in Pau: Transcription Interview with Paul Nash
Creators: name: Milne, Andrew
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024

description: Migratory trajectory and oral history of English speakers in the city of Pau
Decentralized Mapping of Robot-Aided Sensor Networks
Creators: name: Djugash, Joseph A.
name: Singh, Sanjiv
name: Grocholsky, Benjamin
Publisher: name: Carnegie Mellon University
Year: 2008
Subjects: subject: 80101 Adaptive Agents and Intelligent Robotics
subject: FOS: Computer and information sciences

description: A key problem in the deployment of sensor networks is that of determining the location of each sensor such that subsequent data gathered can be registered. We would also like the network to provide localization for mobile entities, allowing them to navigate and explore the environment. In this paper, we present a robust decentralized algorithm for mapping the nodes in a sparsely connected sensor network using range- only measurements and odometry from a mobile robot. Our approach utilizes an extended Kalman filter (EKF) in polar space allowing us to model the nonlinearities within the range-only measurements using Gaussian distributions. We also extend this unimodal centralized EKF to a multi-modal decentralized framework enabling us to accurately model the ambiguities in range-based position estimation. Each node within the network estimates its position along with its neighbor's position and uses a message-passing algorithm to propagate its belief to its neighbors. Thus, the global network localization problem is solved in pieces, by each node independently estimating its local network, greatly reducing the computation done by each node. We demonstrate the effectiveness of our approach using simulated and real-world experiments with little to no prior information about the node locations.
Dynamics of Warm-Absorbing Gas in Seyfert Galaxies: NGC 5548
Creators: name: Bottorff, Mark
name: Korista, Kirk
name: Shlosman, Isaac
Publisher: name: arXiv
Year: 2000
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: A hydromagnetic (MHD) wind from a clumpy molecular accretion disk is invoked to explain observations of warm absorbing (WA) gas in UVX from Sy galaxies. This paper focuses on two issues: (1) compatibility of kinematics and dynamics of MHD wind with the observed properties of WAs; and (2) relationship between the UVX absorptions. We provide an in-depth comparison between the MHD model and the Sy 1 galaxy NGC 5548, which at high spectral resolution exhibits a number of discrete UV absorption components. We find that: (1) the total column densities of Ovii, Oviii and H, are reproduced by constraining the UV ion column densities of Civ and Nv in each component to lie within a factor of 2 of their observed values and optimizing over the possible sets of component ionization states and Civ column densities; (2) the WA exists in the outer part of the wind and is not a continuation of the flow in the BLR; and (3) the WA extends in radial and polar directions and is ionization-stratified. X-ray absorption is found to be heavily biased towards smaller r, and UV absorption originates at larger distances from the central continuum source. We show that the discrete absorption components along the line-of-sight are intrinsically clumpy. Density differences between kinematic components result in a range of ionization and recombination timescales. We further test the applicability of the MHD wind to WAs in general, by constructing a quasi-continuous flow model, and extending it to arbitrary aspect angles. We estimate the fraction of Sy 1s having detectable WAs with larger Ovii column density than Oviii, and the range of total H column densities. We also find that the ratio of Ovii to Oviii optical depths can serve as a new diagnostic of AGN aspect angle.
description: Latex, 8 postscript figures. Astrophysical Journal, 536, June 10, in press
Towards a fully massive five-flavour scheme
Creators: name: Krauss, Frank
name: Napoletano, Davide
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In this work we explore first necessary steps to contruct a fully massive version of a variable flavour number scheme. In particular we focus, as an example, on an extension of the five-flavour scheme, where instead of neglecting explicit initial state quark mass effects, we retain all massive dependence, while keeping the resummation properties of the massless five-flavour scheme. We name this scheme five-flavour-massive (5FMS) scheme. Apart from consistently modified parton distribution functions, we provide all the ingredients that are needed to implement this scheme at MC@NLO accuracy, in a Monte Carlo event generator. As proof of concept we implement this scheme in SHERPA, and perfom a comparison of the new scheme with traditional ones for the simple process of scalar particle production in bottom quark fusion.
description: 16 pages, 7 figures
Additional file 1 of Cancer cell line microarray as a novel screening method for identification of radioresistance biomarkers in head and neck squamous cell carcinoma
Creators: name: Routila, Johannes
name: Suvila, Karri
name: Grénman, Reidar
name: Leivo, Ilmo
name: Westermarck, Jukka
name: Ventelä, Sami
Publisher: name: figshare
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Hematology

description: Additional file 1: Figure S1. Representative examples of low and moderate PME-1 and moderate and strong SET stainings.