cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Design of a lunar surface structure
Creators: name: Mottaghi, Sohrob
Publisher: name: No Publisher Supplied
Year: 2013

description: The next step for manned exploration and settlement is a return to the Moon. In such a return, the most challenging task is the construction of structures for habitation, considering the Moon’s hostile environment. Therefore the question is: What is the best way to erect habitable structures on the lunar surface?   Given the cost associated with bringing material to the Moon, In-Situ Resource Utilization (ISRU) is viewed by most as the basis for a successful manned exploration and settlement of the Solar system. Along these lines, we propose an advanced concept where the use of freeform fabrication technologies by autonomous mini-robots can form the basis for habitable lunar structures. Also, locally-available magnesium is proposed as the structural material. While it is one of the most pervasive metals in the regolith, magnesium has been only suggested only briefly as a viable option in the past. Therefore, a study has been conducted on magnesium and its alloys, taking into account the availability of the alloying elements on the Moon.  An igloo-shaped magnesium structure, covered by sandbags of regolith shielding and supported on a sintered regolith foundation, is considered as a potential design of a lunar base, as well as the test bed for the proposed vision. Three studies are carried out:    First a static analysis is conducted which proves the feasibility of the proposed material and method.    Second, a thermal analysis is carried out to study the effect of the regolith shielding as well as the sensitivity of such designs to measurement uncertainties of regolith and sintered thermal properties. The lunar thermal environment is modeled for a potential site at 88º latitude in the lunar South Pole Region. Our analysis shows that the uncertainties are in an acceptable range where a three-meter thick shield is considered. Also, the required capacity of a thermal rejection system is estimated, choosing the thermal loads to be those of the Space Station modules.   In the third study, a seismic model based on best available data has been developed and applied to our typical structure to assess the vulnerability of designs that ignore seismicity.  Using random vibration and modal superposition methods, the structural response to a lunar seismic event of & Richter magnitude indicates that the seismic risk is very low. However, it must be considered for certain types of structural designs.
The effect of cholesterol on the stability of a DPPC-cholesterol bilayer
Creators: name: Muralidharan, Bharatram
Publisher: name: No Publisher Supplied
Year: 2013

description: Cholesterol plays a very important part in regulating the properties of mixed phospholipid bilayers. In a human cell, about 50% is covered in cholesterol, and is becoming increasingly important to understand the interactions between cholesterol and the lipid in maintaining properties of the membrane, and in particular its stability more clearly. In an age of increased computer dependence, simulation models based on basic interaction parameters could prove pivotal in advancements in fields such as nano-medicine or monitoring the effect of viruses on cells. In this thesis, a mesoscopic model system of Dipalmitoylphosphatidylcholine (DPPC)-Cholesterol and water, is used to mimic a typical biological membrane. The equilibrium conformation of a membrane requires a tensionless state of the membrane. Depending on the tension, a membrane could either stretch or fold (compression). Simulations using Dissipative Particle Dynamics were used and the concentration of cholesterol was varied and the resulting tension was observed.
Cyprinus carpio Linnaeus 1758
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Cypriniformes
Cyprinidae
Cyprinus
Cyprinus carpio

description: * Cyprinus carpio Linnaeus 1758 (Fig. 6L). Common Carp; Carpa Común, Carpa
Vouchers: Not available. Distribution: Western Europe; Black, Caspian and Aral seas basins; introduced throughout the world; (Nicaragua) GM, Es and LN (Atlantic); 10–700 masl; Pri, Pot. Occurrence and conservation status: Exo. Literature: Villa (1982: 110; detailed description, including illustrations and an identification key, and information on distribution and ecology), Bănărescu & Paepke (2002: 115, 184; detailed description, including illustrations, and information on distribution and ecology) and Angulo (2021: 23; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 20, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Nanomaterial inhalation exposure from nanotechnology-based consumer products
Creators: name: Nazarenko, Yevgen
Publisher: name: No Publisher Supplied
Year: 2013

description: Certain kinds of nanomaterials have been shown to cause serious health effects. When various nanomaterials are introduced into consumer products, their use could lead to nanomaterial inhalation exposure with possible health effects. We explored the potential of this exposure for several consumer sprays and cosmetic powders including products marketed as nanotechnology-based and alternative non-nanotechnology-based products. Actual application of real world products was realistically simulated and the inhaled aerosol was measured directly. We described: 1) the nanoparticles and nano-agglomerates in products, to which exposure could occur during application by consumers; 2) the potential for inhalation exposure to nanomaterial-containing particulate matter, generated during product application; and 3) the quantitative nanomaterial inhalation exposure as both inhaled dose and dose deposited in different regions of the human respiratory tract (for the cosmetic powders only). Particles in the products were investigated using transmission electron microscopy (TEM), photon correlation spectroscopy (PCS) and laser diffraction spectroscopy (LDS). We then realistically simulated the use of the products by spraying them in the vicinity of a female mannequin head or applying directly onto its face in the case of cosmetic powders. A Scanning Mobility Particle Sizer (SMPS) and an Aerosol Particle Sizer (APS) were used to measure the “inhaled” aerosol particle size distributions by drawing aerosol through the mannequin’s nostrils. The measurement data for powders were also used in an inhalation exposure model. Nanoparticles were found in both the nanotechnology-based and regular products. We could not, however, determine their engineered status. It was concluded that the highest inhalation exposure to nanomaterials in the investigated consumer products would occur due to inhalation and deposition of nanoparticle agglomerates larger than 100 nm – not individual nanoparticles or nanosized agglomerates. For the cosmetic powders, inhaled particle deposition in the head airways constituted the dominant portion (85-93%) of the total deposited dose overwhelming the deposition in the tracheobronchial and the alveolar regions. Hence, the future toxicology studies of nanotechnology-based consumer products should take into account exposures not only to single nanoparticles, but also to much larger nanoparticle agglomerates and investigate the potential biological effects in all regions of the respiratory tract.
Real time optimization of emergency response
Creators: name: Nelson, Christie Leigh
Publisher: name: No Publisher Supplied
Year: 2013

description: From 1980 to 2011, the total loss from weather-related catastrophes was $1,060  billion in 2011 USD [60] and 30,000 people lost their lives in North America. The  number of weather-related catastrophes is only increasing, with an increase factor of  nearly 5 in North America over the past 30 years.    In real-time scenarios an accurate picture of the situation is needed quickly. Often  during large-scale disasters, cell towers become overloaded, and the only way of  communication is through text messages. It becomes important to gather information  from text messages sent to emergency numbers in order to respond quickly and  efficiently with life-saving efforts. In addition, responders are unable to manually handle  the large volume of incoming texts. Real-time information from streaming data is  needed, and responders would benefit from text classification of incoming messages. To  add to this difficult problem, these data sources tend to be microtext, which makes the  problem of modeling the data more challenging.    The goal of this Dissertation research was to develop a methodology to summarize  text messages sent during an emergency for use by responders, including analysis of  locations to identify geospatially potentially new areas of population in need of   emergency assistance. The real-time disaster needs were then input into a mixed integer  programming resource allocation model for distribution of resources for disaster aid.  Prior research included resource allocation and text modeling, but the combination of the  two was a novel application not only in this arena, but more broadly across domains. The  model found the emerging real-time needs by geolocation. Two methods were evaluated  for determining these emergency needs: a supervised method modeled the data with a  variation of Naïve Bayes, Higher-Order Naïve Bayes (HONB), and an unsupervised  approach modeled the data with a variation of Latent Dirichlet Allocation, Higher-Order  Latent Dirichlet Allocation (HO-LDA). It was found that HONB performed better on  domain relevant data than Naïve Bayes, and HO-LDA performed better than LDA. Also,  the use of Higher-Order Learning in conjunction with clustering geolocations to  determine emerging population centers during an emergency centralized response, which  reduced the unmet humanitarian aid need.
WORD MATN MUHARIRIDA SOʻROVNOMA TAYYORLASH
Creators: name: Malikova, Dilnavo
name: Nurullayeva, Malika
name: Yaxiyaxonova, Muxiba
Publisher: name: Zenodo
Year: 2025

description: Yangi hujjat yaratish. Dasturda yangi hujjat ochamiz. Sarlavha kiritish. Soʻrovnoma mavzusini ifodalovchi sarlavha yozamiz. Savollarni belgilash. Kerakli savollarni roʻyxatga olamiz, ularni aniq va tushunarli ifodalaymiz. Javob variantlarini kiritamiz. Yopiq savollar uchun javob variantlarini koʻrsatamiz. Formatlash. Savollar va javoblarni koʻrinishi uchun formatlaymiz. Izoh qoʻshish. Har bir savolga izoh yoki qoʻshimchalar kiritamiz. Tahrir va tekshirish. Hujjatni xatolarni tuzatamiz va oʻzgartirishlar kiritish uchun koʻrib chiqamiz. Saqlash. Tayyor hujjatni saqlaymiz va kerak boʻlsa, tarqatish uchun chop etamiz. Ushbu jarayon, soʻrovnoma tayyorlashda samaradorlikni oshirishga yordam beradi va kerakli maʻlumotlarni toʻplash imkonini beradi.
Impact of glucuronic acid substitution on the chemistry of heparin-derived oligosaccharides
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: This proposal aims to study the effect of glucuronic acid (GlcA) substitution for iduronic acid (IdoA) on the chemistry of heparin-derived oligosaccharides. A library of oligosaccharides will be isolated by enzymatic digestion of heparin followed by size-exclusion chromatography fractionation and strong anion-exchange chromatography (SAX). The structures of the oligosaccharides will be characterized by reverse-phase ion pair HPLC-MS and NMR. The resulting database of analytical information will be used to assign the identity of heparan sulfate (HS) oligosaccharides. Oligosaccharide pairs differing only in the configuration of a single uronic acid residue (i.e., IdoA or GlcA) will be evaluated for their relative binding affinity with the basic fibroblast growth factor, FGF-2. Ligand-detected NMR experiments will be used to detect interactions of the oligosaccharides with FGF-2 and evaluate the conformation of the bound oligosaccharides. These experiments will provide new information about the structural requirements for FGF-2 binding and the role of the uronic acid residues in binding. IdoA is thought to confer conformational flexibility to heparin and heparan sulfate (HS) and be important for binding. We hypothesize that the much longer retention time of identical tetra- and hexasaccharides in which GlcA is substituted for IdoA, may instead point to more effective binding by GlcA residues. Oligosaccharides will also be isolated from HS produced by cultured human kidney cells. The structures of the HS oligosaccharides will be determined by measurement of retention time, mass, fragmentation patterns and, as feasible proton NMR survey spectra. HS analytical data will be compared with the database produced for the library of isolated heparin oligosaccharides. These results will provide important insights into the extent to which the isolated heparin oligosaccharide library is representative of the structural elements embodied in HS, especially among those sequences determined to have high affinity for FGF-2. These results will have a significant impact on our understanding of the role of heparin and HS in cancer development and metastasis and may provide novel structural motifs as inspiration for the synthesis of new therapeutic agents.
Conus (Taranteconus) polongimarumai
Creators: name: Tenorio, Manuel J.
name: Puillandre, Nicolas
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Neogastropoda
Conidae
Conus
Conus polongimarumai

description: Conus (Taranteconus) polongimarumai (Kosuge, 1980)
Figs 2, 82I–L, N, 84
Conus polongimarumai Kosuge, 1980a: 63, pl. 18 figs 6–8.
Conus polongimarumai – R̂ckel et al. 1995b: no. 243, pl. 52 figs 21–24.
Taranteconus polongimarumai – Tucker & Tenorio 2013: 324. — Monnier et al. 2018a: 288.
Material examined
14 lots (about 20 specimens). See Supp. file 1.
Type material
Holotype PHILIPPINES • 22.5 mm; Punta Engaño, Mactan Island; IMT 80-63.
Figured material
NEW CALEDONIA • 20.5 mm; Norfolk Ridge, Munida, off New Caledonia, stn DW3106; 23°02′ S, 168°21′ E; 180‒220 m depth; 27 Oct. 2008; TERRASSES expedition (Fig. 82I) • 19.4 mm; Grand Passage, off New Caledonia, stn DW2985; 18°59′ S, 163°06′ E; 277‒289 m depth; 5 May 2008; CONCALIS expedition; MNHN (Fig. 82J) • 18.9 mm; same collection data as for preceding; MNHN (Fig. 82K) • 17.3 mm; same collection data as for preceding; MNHN (Fig. 82L) • 21 mm; Pouembout, New Caledonia; 80–90 m depth; Franck Leterrier coll. (Fig. 82N).
Geographical distribution and bathymetry
Philippines, Marshall Islands, W Thailand, in shallow water to 350 m deep. In New Caledonia it has been sampled at depths between 100 to 500 m in the Coral Sea, Grand Passage area, Norfolk Ridge and Loyalty Islands.
Remarks
Shell small (maximum shell length 30 mm), conical with a moderate to high, stepped spire of straight to slightly concave profile. Spire whorls and shoulder with strong nodules continuing as axial costae below. Multispiral protoconch of about 3 whorls. Radular tooth (Fig. 82N) with the anterior section much shorter than the posterior section. Tooth serrated with 7–8 denticles arranged in one row, ending on a large, pointed cusp. Barb moderate. Blade prominent and pointed, covering about 80–90% of the anterior section of the tooth. Strong basal spur present on top of the very large base. In the phylogeny (Fig. 2), C. (T.) polongimarumai is sister to C. (T.) chiangi.
description: Published as part of Tenorio, Manuel J. & Puillandre, Nicolas, 2023, Revision of the deep-water cone snail fauna from New Caledonia (Gastropoda, Conoidea), pp. 1-134 in European Journal of Taxonomy 896 on pages 112-113, DOI: 10.5852/ejt.2023.896.2291, http://zenodo.org/record/8405510
Tetramorium sikorae Forel
Creators: name: Bolton, B.
Publisher: name: Zenodo
Year: 1979
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium sikorae

description: Tetramorium sikorae Forel
Tetramorium (Xiphomyrmex) sikorae Forel, 1892: 522. Syntype workers, Madagascar: Amparafaravantsiv (Sikora) (MHN, Geneva) [examined]. Xiphomyrmex latior Santschi, 1926: 243. Syntype workers, Madagascar: Fananantsoa [= Fianorantsoa on data label] (Descarpentries) (NM, Basle) [examined]. Syn. n.
Worker. TL 2.7 - 3.2, HL 0.64 - 0.70, HW 0.54 - 0.60, CI 84 - 91, SL 0.40 - 0.46, SI 71 - 80, PW 0 - 42 - 0.48, AL 0.74 - 0.88 (5 measured).
Mandibles smooth with scattered small pits, median clypeal carina distinct. Frontal carinae extended back well beyond the level of the eyes, almost parallel and forming the upper margins of a shallow scrobe which is capable of accommodating the scape. With the alitrunk in profile the metanotal groove shallowly impressed. Propodeum armed with a pair of short, triangular teeth which are shorter than the broadly triangular metapleural lobes. Dorsum of head with very fine longitudinal rugulae and a distinct interrugal sculpture of fine but conspicuous superficial puncturation. Dorsal alitrunk finely rugulose, the pedicel and gaster unsculptured, smooth and shining. Erect or suberect long, fine hairs present on all dorsal surfaces of the body but may be absent from the pedicel segments. Colour yellow-brown.
A small and quite distinctive species, sikorae has nevertheless been confused with the cognatum complex in the past. The best character for separating them lies in the fact that sikorae has numerous erect or suberect hairs on the first gastral tergite; such hairs being absent in cognatum and its allies.
Within the schaufussi-group, sikorae forms the central species of what may be loosely termed the sikorae-complex, including the close pair of sikorae and schaufussi, and the rather more distantly related xanthogaster, all of them possessing, within the schaufussi-group, hairs on the first gastral tergite. In xanthogaster the frontal carinae are feeble, scrobes are absent and the propodeal spines are quite long, besides which the species is bicoloured. The two remaining species are best separated by the characters given under schaufussi.
Material examined
Madagascar: vic. Andasibe (= Perinet) (W. L. & D. E. Brown). Reunion I. (ex coll. Mayr).
description: Published as part of Bolton, B., 1979, The ant tribe Tetramoriini (Hymenoptera: Formicidae). The genus Tetramorium Mayr in the Malagasy region and in the New World., pp. 129-181 in Bulletin of the British Museum (Natural History) Entomology 38 on pages 138-139
The psychology of genocide and the Perpetration of Extreme Violence (PEV) model
Creators: name: Nofziger, Heather Anne
Publisher: name: No Publisher Supplied
Year: 2013

description: This dissertation examines the processes by which psychologically normal individuals become willing participants in genocide via a four-part discussion. Part one provides a review of the literature on the psychology of genocides and critiques the existing theoretical models. Part two then presents a new theoretical framework and introduces the Perpetration of Extreme Violence model. Part three applies this new framework to the analysis of an actual instance of extreme violence: the 1994 genocide in Rwanda; and examines the degree to which the PEV model maps onto both the broader course of events and the experiences of the actual perpetrators. Finally, part four utilizes two empirical studies to test several of the underlying predictions of the PEV model. Study One reveals that, consistent with the PEV’s predictions, the degree to which individuals endorse harm-legitimizing ideologies about a target group is positively related to levels of outcome attitudes associated with the first three stages, as well as general levels of hatred and support for harmful policies directed at the target group. Study 2 then takes the analysis a step further by focusing on two additional predictions: (1) that exposure to harm-legitimizing ideologies could increase endorsement of these ideologies, ultimately resulting in more negative attitudes and support for harmful policies directed at the target group and (2) that the effects of ideology exposure on endorsement would be moderated by individual levels of Right-Wing Authoritarianism, Social Dominance Orientation and/or Ingroup Identification Strength. Results fail to support both hypotheses suggesting that a single exposure to harm-legitimizing ideology is not strong enough to produce real attitude/belief change. Implications, limitations and future directions are discussed.
Bryconidae Eigenmann 1912
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Characiformes
Bryconidae

description: Family Bryconidae Eigenmann 1912 (Fig. 3A). Machacas, Macabí Tetras, Bryconids; Machacas, Sábalos, Sabaletes
Description: Body elongate, robust and slightly rounded to fusiform; up to 70 cm in length; snout blunt, prominent; upper jaw projecting well beyond the tip of the lower jaw in most species, upper jaw with 3 rows of multicuspid teeth; fins spine-less; adipose fin present; caudal fin forked; usually silvery in color (Angulo & Gracián-Negrete 2013, Angulo et al. 2021). Distribution: Freshwater; southern Mexico to Argentina (Angulo & Gracián-Negrete 2013, Nelson et al. 2016). One genus and two species in Nicaraguan freshwaters.
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 20, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Enantioenriched di- and triarylmethanes as anticancer agents for prostate cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The long-term goal of my research program is to develop new catalytic reactions for the synthesis of important pharmacophores and to apply these methods to prepare known and novel compounds for biomedical research. The overarching objective of this project is to identify lead compounds for anticancer agents with activity against prostate cancer. The specific aims of this project are to develop chemical methods for enantioselective synthesis of diarylmethanes and triarylmethanes, prepare small (30-50 compound) libraries of these compounds, and test these compounds for activity against androgen-independent and dependant prostate cancer cell lines. Di- and triarylmethanes are steroid mimics with promise as lead compounds for the development of small molecule anticancer agents for the treatment of hormone dependent and independent cancers including castration-resistant prostate cancer. We will develop synthetic methods for preparation of diarylmethanes that are combretastatin analogs, by examining cross-coupling of non-extended benzylic ethers. To achieve synthesis of enantioenriched triarylmethanes, tamoxifen analogs, we will develop reactions of aryl Grignard reagents. Our strong preliminary results in stereospecific cross-coupling reactions of ethers place us in a unique position to develop these transformations. We will use a mechanism-based design of catalyst and reaction conditions to achieve each goal. The structures of each analog will be chosen to test our hypothesis that they will mimic steroid binding to the androgen receptor. Compounds will be prepared in both enantiomeric series to obtain three-dimensional structure-activity relationships. In preliminary biological screens, compounds will be tested for activity against androgen-independent and dependant prostate cancer cell lines. Promising compounds will be subjected to more specific assays designed to identify compounds that selectively bind to the androgen receptor.
Additional file 2: of Trade-offs in the production of animal vocal sequences: insights from the structure of wild chimpanzee pant hoots
Creators: name: Fedurek, Pawel
name: ZuberbĂźhler, Klaus
name: Semple, Stuart
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Neuroscience
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Table with estimated age and the dominance rank of the study males, and the number of recordings per male. (DOCX 52Â kb)
Design and analysis of the Federal Aviation Administration Next Generation Fire Test burner
Creators: name: Ochs, Robert Ian
Publisher: name: No Publisher Supplied
Year: 2013

description: The United States Federal Aviation Administration makes use of threat-based fire test methods for the certification of aircraft cabin materials to enhance the level of safety in the event of an in-flight or post-crash fire on a transport airplane.  The global nature of the aviation industry results in these test methods being performed at hundreds of laboratories around the world; in some cases testing identical materials at multiple labs but yielding different results.  Maintenance of this standard for an elevated level of safety requires that the test methods be as well defined as possible, necessitating a comprehensive understanding of critical test method parameters.  The tests have evolved from simple Bunsen burner material tests to larger, more complicated apparatuses, requiring greater understanding of the device for proper application.  The FAA specifies a modified home heating oil burner to simulate the effects of large, intense fires for testing of aircraft seat cushions, cargo compartment liners, power plant components, and thermal acoustic insulation.  Recently, the FAA has developed a Next Generation (NexGen) Fire Test burner to replace the original oil burner that has become commercially unavailable.  The NexGen burner design is based on the original oil burner but with more precise control of the air and fuel flow rates with the addition of a sonic nozzle and a pressurized fuel system.  Knowledge of the fundamental flow properties created by various burner configurations is desired to develop an updated and standardized burner configuration for use around the world for aircraft materials fire testing and airplane certification.  To that end, the NexGen fire test burner was analyzed with Particle Image Velocimetry (PIV) to resolve the non-reacting exit flow field and determine the influence of the configuration of burner components.  The correlation between the measured flow fields and the standard burner performance metrics of flame temperature and burnthrough time was studied.  Potential design improvements were also evaluated that could simplify burner set up and operation.
The Role of Wnt5a/Ror2 signaling in mammary stem cell renewal
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The cellular origin of breast cancer is a key topic of interest as it may shed light on the development of more effective treatments. Many types of breast cancer share common signatures with mammary stem cells and progenitor cells, suggesting that dysregulation of these normal cells leads to tumorigenesis.Wnt5a/Ror2 signaling shows great promise as a regulator of mammary stem and progenitor cells. This pathway is important for normal breast development and acts as a tumor suppressor pathway. This study proposes to elucidate the role of Wnt5a/Ror2 signaling in regulating mammary stem and progenitor cells in normal mammary gland. We hypothesize that the Wnt5a/Ror2 signaling axis plays a critical role as a non-renewal pathway for stem cells in the mammary gland. Further, we hypothesize that it opposes the actions of canonical WNT signaling by regulating the subcellular localization of ß-catenin. We propose to test these hypotheses by using gain-of-function experiments to analyze the effects of Wnt5a on mammary stem cells, along with loss-of-function experiments to study the renewal properties of Ror2-/- mammary stem cells. My laboratory has a unique opportunity to perform these studies due to our collaboration with Dr. Zeng, who recently showed the role of Wnt3a as a renewal factor for mammary stem cells, and Dr. Minami and Dr. Nusse from whom we will receive the Ror2-/- mice. The results from this study will determine if Wnt5a/Ror2 signaling is responsible for inhibiting mammary stem cell self-renewal, and if loss of this regulation leads to stem cells that have lost their proliferative constraints. By providing insight into the mechanisms by which normal stem/progenitor cells are regulated, this research promises to provide insight into how this pathway functions in breast tumorigenesis.
Rewriting orthodoxy
Creators: name: O'Neal, Devin John
Publisher: name: No Publisher Supplied
Year: 2013

description: In my dissertation I investigate literary representations of mythological and religious tropes in select prose German-language texts of Classicism and Early Romanticism dating from 1&8&-1812, and explore their use in questioning the prevailing religious views of the time. My overarching analysis has three goals: (1) to extract certain mythological traits and tropes from these texts and compare them to the original stories or figures on which they are based; (2) to explain the function of these mythological and religious rewritings within each narrative; and (3) to explain the function these rewritings have in relation to the Romantic concept of religious Bildung, especially concerning the standard Judeo-Christian monotheistic and patriarchal view of spirituality.   The presence of rewritten myth has led me to focus on four prose texts in particular – Johann Wolfgang von Goethe’s Wilhelm Meisters Lehrjahre (1&95/96), Friedrich Schiller’s Der Geisterseher (1&8&-89), Johann Ludwig Tieck’s Der Runenberg (1804), and Ludwig Achim von Arnim’s Isabella von Ägypten (1812). I argue that these texts, to varying degrees, recognize the possibility that spirituality and religion may have qualities beyond the monotheistic framework set by standard religious belief. My readings of these texts as literary forms of religious enquiry stem from the developing Romantic aesthetic theory of the period, which not only began to challenge the artistic limitations imposed by Classic aesthetic ideals, but also attempted to call into question the reason-based arguments for standard monotheistic beliefs that were prominent in the Enlightenment period.
The process of organizing personal information
Creators: name: Oh, Kyong Eun
Publisher: name: No Publisher Supplied
Year: 2013

description: The purpose of this study is to explore the process of organizing personal information in digital forms from a cognitive sociological perspective. This study also aims to develop a model that explains the personal information organization process.   Participants of this study were 18 academics in three different professional age groups. To collect data, a background questionnaire, a diary study, and two semi-structured interviews were conducted with each of the participants. After completing the background questionnaire, participants were asked to keep diary entries over a week whenever they decided to save or organize their personal information items in digital forms. Then, the first interview was conducted to ask how and why they organized their information in certain ways. About 2-4 weeks after the first interview, the second interview examined whether participants made any changes to the information items and categories discussed in the first interview. To analyze data, all the interviews were recorded, transcribed, and coded with a set of categories, which were developed based on the analysis of the literature. Then, the researcher confirmed, modified, or extended the initial categories while analyzing the empirical data. Additionally, each of the diary entries then underwent content analysis.    The findings show that the process of organizing personal information consists of six stages: (1) Initiation; (2) Identification; (3) Temporary Categorization; (4) Examination/Comparison; (5) Selection/Modification/Creation; and (6) Categorization. These stages involve different actions, thoughts, and decisions, and various factors influence the process. The findings indicate that the organizing process is heavily influenced by participants’ social environments. In this study, the personal information organization process (PIOP) model, which holistically shows the ranges of behaviors that are involved during the personal information organization process, has been developed.    This study deepens our understanding about people’s information organization process by providing an integrated view of the process. In particular, by providing an explanation of the social aspects of personal information organization, this study makes a unique contribution to the field. This study also contributes to the development and design of various personal information devices, interfaces, and applications that support individuals’ organization of their information.
Modeling oncolytic adenovirus
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: This project will study early infection by oncolytic adenoviruses to obtain parameters that will allow improved mathematical modeling of oncolytic adenovirus infection in tumors. The approach will be to employ recombinant adenoviruses expressing enhanced green fluorescent protein (EGFP), which allows visualization of infected cells. A system for serial observation of the same initial infection even has been established, and recombinant EGFP-expressing viruses equivalent to wild-type and dl1520 (aka ONYX-015, lacking E1B 55K protein) have been generated. These viruses will be observed in p53-negative and positive tumor cell lines. Basic parameters of early infection in monolayer will be determined, and effects of MOI on kinetics of virus spread will be determined. These studies will also be extended to studying infection of solid masses of tumor cells, and kinetic parameters will be determined there as well. These measurements will allow improved mathematical modeling of oncolytic virus infection, which may allow modifications leading to successful application of oncolytic viruses in the clinic.
Brycon guatemalensis Regan 1908
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Characiformes
Bryconidae
Brycon
Brycon guatemalensis

description: Brycon guatemalensis Regan 1908. Machaca, Macabí Tetra; Sábalo, Pescado Blanco
Vouchers: Not available. Distribution: Central America; from southern Mexico to northwestern Nicaragua,Atlantic and Pacific drainages; (Nicaragua) Ch (Pacific); 279–319 masl; Pri, Pot. Occurrence and conservation status: Nat; LC (2019), population trend unknown. Literature: Carr & Giovannoli (1994: 100; brief description, including information on distribution and ecology) and Angulo & Gracián-Negrete (2013: 255; brief description, including an identification key, and information on distribution)
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 22, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Additional file 3: of Trade-offs in the production of animal vocal sequences: insights from the structure of wild chimpanzee pant hoots
Creators: name: Fedurek, Pawel
name: Zuberbühler, Klaus
name: Semple, Stuart
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Calculation of the dominance status of the study males. (DOCX 107 kb)
Novel enzymatic capture methods for the ultrasensitive microarray detection of microRNA
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The development of novel methods for the detection and quantitation of multiple microRNA (miRNA) cancer biomarkers at femtomolar concentrations through the combined use of biofunctionalized fluorescent nanoparticles, surface enzyme chemistry and total internal reflection fluorescence (TIRF) imaging microarray biosensing is proposed. DNA-modified silica fluorescent nanoparticles will be used to capture extremely small amounts (thousands of molecules) of target miRNAs via an enzymatic surface ligation. The nanoparticles will then be separated, concentrated and detected in a microarray format with TIRF imaging measurements. These ultrasensitive biosensing technologies will facilitate the creation of new methods for earlier and more precise cancer identification and detection.
Design, synthesis, and fabrication of biodegradable, bioactive-based polymers for controlled release applications
Creators: name: Ouimet, Michelle Aimee
Publisher: name: No Publisher Supplied
Year: 2013

description: Novel, controlled release drug delivery systems have transformed therapeutics used in modern medicine but exhibit limitations for treating various diseases.  Biodegradable polymers have been extensively studied to overcome such challenges.  Through incorporating therapeutic bioactives into a polymer backbone via hydrolytically degradable bonds, high drug loading, improved delivery, and enhanced bioactive stability can be achieved.  Polymers containing a non-steroidal anti-inflammatory drug, salicylic acid, and antioxidant molecules from the hydroxycinnamic acid class were synthesized into bioactive-based poly(anhydride-esters) as controlled release drug delivery systems.  Polymer properties have been tuned by changing the bioactive covalently incorporated into the monomer unit, altering the monomer’s molecular structure, adding small molecules to the polymer matrix, and fabricating the polymer into different devices.  Salicylic acid-based poly(anhydride-ester) (SAPAE) release profiles were first tuned using small molecule admixtures at varying weight percentages to overcome a lag period (i.e., no drug release) for applications where immediate, constant drug release is desired.  SAPAEs were also designed as microparticles, or microspheres, for short-term salicylic acid release.  These polymers were prepared using monomers comprised of linear aliphatic or heteroatomic molecules with two salicylic acid units.  Microsphere size and morphology was determined and the in vitro drug release profile ascertained.  Furthermore, to impart brittle SAPAEs with flexible, soft tissue-like properties, the polymer was blended with poly(vinyl pyrrolidone) to formulate miscible films that, when hydrated, exhibit hydrogel-like properties.  The material’s morphology, thermal properties, and in vitro drug release profile were elucidated.    In addition to engineering SAPAEs for various applications, hydroxycinnamic acids such as p-coumaric, ferulic, and sinapic, which are potent antioxidants with short half-lives and poor chemical stability, were covalently incorporated into a polymer backbone.  The chemical composition of precursors and polymers were confirmed and the polymers’ physicochemical characteristics and drug release profiles ascertained.  Moreover, the ferulic acid-containing polymer chemical structure was tuned to alter the physicochemical properties and drug release rates.  The design, synthesis, physicochemical characterization, drug release profiles, bioactivity assessments, device fabrication methods, biocompatibility evaluations, and potential applications of various bioactive-containing poly(anhydride-ester) are discussed herein.
Assessment on the Effectiveness of Universal Health Care (UHC) Law in the Philippines during the Covid-19 Pandemic: An Analysis
Creators: name: Lee, Christopher M.
name: Gomez, Sheryll Lumen
name: Paz, Bien Mark Anthony
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 420315
subject: One health
classificationCode: 380108
subject: Health economics
classificationCode: 420307
subject: Health counselling
classificationCode: 420311
subject: Health systems
classificationCode: 420309
subject: Health management
classificationCode: 470210
subject: Globalisation and culture

description: The Philippines’ Universal Health Care (UHC) Law are indeed one of the public policies that are considered mandatory towards our health care interventions and primarily concern with the basic healthcare problems like the Covid-19 Pandemic that strikes the Philippines last 2020-2022, and the healthcare services towards Filipinos. It likewise gives us healthcare assistance on both rural and urban facility conveniences. The construction of the research article is to give importance to UHC Law, and how these public policy help us to improve our healthcare systems and services. Because, If we talked about personal health, many people may agree that “Health is wealth, and Health must be prioritize among us.” Meanwhile, the research limits possible circumstances during the progress of the study article. These may discuss in the latter part of the article. And as for the future and potential researches about UHC Law, many people may agree that searching for different healthcare improvement, services and proposed research suggestions always depends on the economic stability and healthcare progress of one nation. That is why the completeness of the research study may set future guidelines and recommendations.
Boundary and Holder regularities of Douady-Earle extensions and eigenvalues of Laplace operators acting on Riemann surfaces
Creators: name: Pal, Susovan
Publisher: name: No Publisher Supplied
Year: 2013

description: Douady-Earle extensions of homeomorphisms of the unit circle are of particular interest in understanding contractibility and complex structures of Teichmueller and assymptotic Teichmueller spaces. Motivated by questions in analysis and partial differential equations, one can ask how regular the Douady-Earle extensions can be on the closed unit disk if one puts sufficient regularity on the circle homeomorphisms to start with. In first part of this thesis which consists of the first four chapters, we prove that Douady-Earle extensions of Holder continuous circle homeomorphisms are Holder continuous with the same Holder exponent, and Douady-Earle extensions of circle diffeomorphisms are diffeomorphisms of the closed unit disk.              Eigenvalues of Laplace operators on Riemannian manifolds are widely studied by differential geometers. But when the manifold is a hyperbolic Riemann surface, the problem becomes more special, because the collar lemma and the minimax principles allow us to construct functions which produce lower and upper bounds on eigenvalues on that Riemann surface. In the second part of this thesis consisting of chapters 5 and 6, we show, using the minimax principles, given any small positive number epsilon and given any big natural number k, we can construct a Riemann surface whose k-th eigenvalue is less than epsilon. The result was first proved by Burton randol, here we provide a much simpler and geometric proof
Barranco León, a 1.4 Ma Human gathering spot in southern Europe
Creators: name: Solano García, José Antonio
Publisher: name: Zenodo
Year: 2025
Subjects: subject: Prehistory
subject: Archaeology
subject: Human evolution
subject: Early Pleistocene
subject: Orce
subject: Spain

description: BARRANCO LEÓN, A 1.4 MA HUMAN GATHERING SPOT IN SOUTHERN EUROPESolano García, José (University of Granada) - Yravedra, José (Universidad Complutense de Madrid) - Titton, Stefania(Institut Català de Paleoecologia Humana i Evolució Social) - Sánchez-Bandera, Christian (Institut Català dePaleoecologia Humana i Evolució Social) - Ochando, Juan (Universidad de Murcia) - Serrano, Alexia (Universidad deGranada) - Herránz, Darío (Universidad de Granada) - González-Quiñones, Juan (Universidad de Granada) - Barsky,Deborah (Institut Català de Paleoecologia Humana i Evolució Social) - Jiménez-Arenas, Juan (Universidad deGranada)Barranco León (Guadix-Baza basin, Spain) is a key archaeological site for the knowledge of the first inhabitants ofSouthwest Eurasia during the Early Pleistocene. It has not only yielded a deciduous lower hominid molar but alsoboasts an exceptionally rich collection of faunal and lithic remains and a fertile palynological record. Recent researchhas led to the development of new interpretative models regarding the formation of the site, the behaviour of homininsand carnivores, and the reconstruction of a new climatic and environmental framework for the Guadix-Baza basin.Our studies point to a typically Mediterranean climate, albeit slightly warmer, specifically in winter, and more humid, ina lakeside margin area where we have discerned different instances of activity, both primary and secondary. The convergenceand recurrence of agents and biological activity suggest that we are dealing with a hotspot for resource provisioningfor different biotic agents, among which hominins and canids (Canis mosbachensis) played a prominent role.Until recently, it was believed that humans had a much more passive and dependent behaviour, relying on externalagents such as large carnivores in a hostile environment, where they would make quick incursions to obtain resources.However, our results suggest a much more complex scenario of interaction and flexibility with the environment, withmore organized and multifunctional groups. Humans played a more important role than previously thought.