cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Global analysis of HIV cellular restriction
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The body’s first line of defense against infection by pathogens, such as HIV, is collectively known as innate immunity. This is coordinated by a number of mechanisms, including proteins in our cells that are dedicated to combating early pathogen invasion. In order for a virus to establish a successful infection, it must counteract or evade this ‘innate immune’ surveillance machinery. Developing drugs to block these viral countermeasures would represent a new, and potentially powerful, strategy to fight HIV/AIDS. However, the complete set of human proteins that guard against HIV infection is not known, thus this significantly impede our ability to develop such new antiviral therapies. In this application, we propose to identify and characterize a comprehensive set of human proteins that function to block HIV infection. We have previously utilized a powerful technology called RNA interference, which allows for the silencing of individual genes in the human gene, to scan the human genome for such molecules. Here, we will propose to experimentally confirm the preliminary data derived this, and similar, analyses. These proposed studies will not only provide significant insight our understanding of how HIV infects human cells, it will open the door for the development of new therapeutic strategies to combat HIV/AIDS.
Martignony, J. De A
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Mailand
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Scaptomyza nigricosta Wheeler & Takada 1966
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Scaptomyza
Scaptomyza nigricosta

description: nigricosta Wheeler & Takada, 1966: 68. Type locality: Colombia, Bogotá area, 8700 ft. HT M (USNM). NT Distr.: Colombia.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 736, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Supplementary material of the study: "Global Scientific Production on behavioural addictions: An analysis of the literature from 1995 to 2019"
Creators: name: Sixto-Costoya, Andrea
name: Castelló-Cogollos, Lourdes
name: Aleixandre-Benavent, Rafael
name: Valderrama-Zurián, Juan Carlos
Publisher: name: Zenodo
Year: 2021
Subjects: behavioural addiction, gambling, gaming, sex addiction, food addiction, sport addiction, shopping addiction, bibliometric study, geographical differences

description: These archives are related to the study about the global scientific publication on behavioural addictions from 1994 to 2019. The behavioural addictions that we considered in our study were: gambling, gaming, ITC related disorders, sex addiction, food addiction, sport addiction, shopping addiction. Here we define the content of each file: - Supplementary material 1: Search equation designed and used in Web of Science to find our results. - Supplementary material 2: Examples of reasons for the exclusion of records that were initially recovered in WoS with the search equation designed. - Supplementary material 3: List of countries that have at least one article about behavioural addiction, with their population, continent and region. The countries and populations were obtained from the World Data Bank.
Merini & Galli
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Mailand
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
TOPOGRAPHIC ANATOMY IN THE MODERN WORLD
Creators: name: Tukhtanazarova, Shavkya
Publisher: name: Zenodo
Year: 2025

description: Topographical anatomy is undergoing rapid development due to the introduction of innovative technologies and an in-depth understanding of the structure and functions of the human body. The article considers new and promising directions of operative surgery and topographic anatomy. It presents data on robotic systems, endoscopy, and laparoscopy, which allow performing complex operations with less trauma and faster patient recovery.
Miniopterus inflatus Thomas 1903
Creators: name: Monadjem, Ara
name: Schoeman, M. Corrie
name: Reside, April
name: P Io, Dorothea V.
name: Stoffberg, Samantha
name: Bayliss, Julian
name: (Woody) Cotterill, F. P. D.
name: Curran, Michael
name: Kopp, Mirjam
name: Taylor, Peter J.
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Miniopteridae
Miniopterus
Miniopterus inflatus

description: Miniopterus inflatus Thomas 1903
Eight individuals were captured at the entrance of a cave system in the Cheringoma plateau (Appendix I), suggesting that a large colony was roosting within the caves. Additional records are from Mount Chiperone and Mount Namuli in northern Mozambique. These constitute the second record of this species from Mozambique. The greatest skull length of two individuals was 16.4 and 16.6 mm, with head lengths of 18.4 and 18.6 mm, respectively. The other six individuals had head lengths of 17.6–18.3 mm, larger than that of M. natalensis but within the range of M. inflatus.
Field measurements: FA (adult male) 47.3 ± 0.47 (46.7–48.1, 7); Bm (adult male) 15.0 ± (14.0–16.0, 7); FA (adult female) 47.0 (1); Bm (adult female) 13.0 (1).
description: Published as part of Monadjem, Ara, Schoeman, M. Corrie, Reside, April, P Io, Dorothea V., Stoffberg, Samantha, Bayliss, Julian, (Woody) Cotterill, F. P. D., Curran, Michael, Kopp, Mirjam & Taylor, Peter J., 2010, A recent inventory of the bats of Mozambique with documentation of seven new species for the country, pp. 371-391 in Acta Chiropterologica 12 (2) on page 385, DOI: 10.3161/150811010X537963, http://zenodo.org/record/3944583
Schulthess, Caspar, Erben
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Zürich
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Sieber-Waser
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Zürich
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Scaptomyza nigripalpis Malloch 1924
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Scaptomyza
Scaptomyza nigripalpis

description: nigripalpis Malloch, 1924: 11. Type locality: Brazil, Rio de Janeiro, Pico das Agulhas Negras (=Alto Itatiai Serro do Itatiaia). HT F (USNM). NT Distr.: Colombia to Brazil. Refs.: Wheeler & Takada, 1966: 43.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 736, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Martenet & Co
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Lima
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Maternal Embryonic Leucine Zipper Kinase in Mammary Tumors
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The maternal leucine zipper kinase (MELK) gene is a potential marker of proliferating mammary epithelial progenitor cells that are highly expressed in multiple human cancers, including human breast cancer. Using a genetically engineered mouse model, we have observed increased expression of Melk in restricted cells of the normal mammary gland and in tumor cells arising due to the expression of activated Neu/ErbB2, Polyoma middle T antigen and Wnt 1 oncogenes. A new targeted mutation of the Melk gene is now available to determine if Melk expression is functionally important to mammary tumor cells caused by an oncogene that uses the same signaling pathways as ErbB2/ErbB3 oncogenes.

 Our objective is to inactivate Melk only in mammary tumor cells to evaluate its importance strictly in cancer cells. We will combine three different genes that have each been engineered for specific reasons. First, the Melk gene has been changed so that it can be permanently inactivated by the action of a protein called Cre recombinase. The second gene codes for the Cre protein and has been engineered to be expressed only in mammary cells and only at puberty. The third gene is a silent gene that expresses a powerful cancer causing protein but only when Cre recombinase removes an inhibitory sequence. Thus in the presence of Cre, this gene will be activated to express the oncogene that causes tumors to form. In the same cell, Cre will inactivate the Melk gene. By comparing mice that either have or do not have the Melk protein, we will be able to determine if Melk is critical for the start and continuation of tumors in the mammary gland.

 This project will permit us to evaluate the effect of Melk in only tumor cells, independently from the neighboring normal cells (stroma) that do not develop into tumors, just as the processes occur in patients. This strategy takes advantage of one the common problems of expressing Cre recombinase in animals. That problem is that rarely is Cre expressed in every cell of a particular tissue. This problem of incomplete expression in all cells of a tissue complicates and in some cases compromises the expected results. In our case this will actually be an advantage, permitting us to evaluate the importance of Melk only in prospective tumor cells.
Scaptomyza pleurolineata Wheeler & Takada 1966
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Scaptomyza
Scaptomyza pleurolineata

description: pleurolineata Wheeler & Takada, 1966: 70. Type locality: Colombia, 30 km N Popayán. HT M (USNM). NT Distr.: Brazil, Colombia.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 736, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Meiss-Reinhard
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Zürich
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Schultz & Hoppe
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Bremen
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
title: Maxwell's Four Cosmos Hypothesis
title: Unified Principles of the Cosmos: From Particles to Galaxies
titleType: AlternativeTitle
Creators: name: starwhisper, Maxwell
Publisher: name: Zenodo
Year: 2025

description: Title: Maxwell's Four Cosmos Hypotheses

Description:

This book explores four ideas about the universe: quantum coupling, layered cosmic systems, natural self-organization, and universal symmetry. These hypotheses connect quantum mechanics and large-scale cosmic structures, offering fresh perspectives on how the universe works.

The hypotheses include:

Quantum Coupling: Invisible links connecting particles and galaxies.

Layered Universe Model: A hierarchical structure of interconnected cosmic layers.

Cosmic Self-Organization: Natural patterns forming across the universe.

Cosmic Crystal Hypothesis: Symmetry and repeating patterns across cosmic scales.

Keywords: #QuantumCoupling #LayeredUniverse #SelfOrganization #Symmetry #Cosmology #DarkMatter #UnifiedFieldTheory
Miniopterus natalensis
Creators: name: Monadjem, Ara
name: Schoeman, M. Corrie
name: Reside, April
name: P Io, Dorothea V.
name: Stoffberg, Samantha
name: Bayliss, Julian
name: (Woody) Cotterill, F. P. D.
name: Curran, Michael
name: Kopp, Mirjam
name: Taylor, Peter J.
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Miniopteridae
Miniopterus
Miniopterus natalensis

description: Miniopterus natalensis (A. Smith 1833)
Three individuals were captured at Gerhard’s Cave and Inhambane in southern Mozambique and a single individual from Mount Mabu in northern Mozambique. Molecular analyses based on cytochrome b show that the individuals from Gerhard’s Cave are similar to M. natalensis (AJ841977.1 — Stadelmann et al., 2004) from Springbok, South Africa.
Field measurements: FA (adult male) 47.1 (46.7– 47.5, 2); Bm (adult male) 10.5 ± (9.0–12.0, 2); FA (adult female) 46.3 (1); Bm (adult female) 10.5 (1).
description: Published as part of Monadjem, Ara, Schoeman, M. Corrie, Reside, April, P Io, Dorothea V., Stoffberg, Samantha, Bayliss, Julian, (Woody) Cotterill, F. P. D., Curran, Michael, Kopp, Mirjam & Taylor, Peter J., 2010, A recent inventory of the bats of Mozambique with documentation of seven new species for the country, pp. 371-391 in Acta Chiropterologica 12 (2) on page 385, DOI: 10.3161/150811010X537963, http://zenodo.org/record/3944583
Scaptomyza samurai Wheeler & Takada 1966
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Scaptomyza
Scaptomyza samurai

description: samurai Wheeler & Takada, 1966: 71. Type locality: Colombia, SE Bogotá, 10000 ft .. HT M (USNM). NT Distr.: Colombia.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 736, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Merian, Gebrüder, in Liquidation
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Basel
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Marchal-Dutailles, Pharmacien
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Sainte-Marie-aux-Mines
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Drosophila striaticeps Wheeler & Takada 1966
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila striaticeps

description: striaticeps Wheeler & Takada, 1966: 72. Type locality: Colombia, Bogotá area, Tequendama Falls. HT M (USNM). NT Distr.: Colombia.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 736, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
A novel role of 14-3-3sigma in breast cancer progression
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The dynamic interplay amongst cells comprising the mammary gland presents a challenge in understanding normal breast biology and how this fine balance is altered in the case of malignancy. Remodeling of the microenvironment by tumorigenic cells is a critical step in cancer progression, with extracellular matrix (ECM) degradation being necessary for invasion into adjacent tissues. The complexity of the breast is reflected in the multiple subtypes of breast cancer that arise within patients. In a cell culture model which recapitulates many features of breast cancer progression(HMT-3522 S1 and T4-2), we recently identified a protein called 14-3-3sigma that becomes highly expressed in malignant T4-2 cells in comparison to their nonmalignant counterpart S1 cells. 14-3-3sigma is a direct transcriptional (gene regulatory) target of the p53 tumor suppressor and is increased in response to chemical or irradiation-induced DNA damage, causing cell cycle arrest at the G2/M checkpoint. As 14-3-3sigma is dogmatically described as a tumor suppressor, the increased expression of 14-3-3sigma in T4-2 cells is compelling and worth investigation as to its potential role in cancer progression.

 To address whether 14-3-3sigma is in fact a tumor suppressor or an oncogene in breast cancer, we will measure expression of 14-3-3sigma in tissues obtained from a large group of patients which has been extensively evaluated with histological markers. To try to understand the role of 14-3-3sigma in the HMT-3522 model of breast cancer progression, we will perform a sophisticated screen (affinity capture proteomics) to identify other proteins that bind to 14-3-3sigma in the cell lines. The interacting proteins will hopefully provide clues as to how 14-3-3sigma regulates tumor progression in this model, and we will validate this data in other cell culture models and in data obtained from patients to identify novel functions of 14-3-3sigma in cancer progression.

 The overall goal of current breast cancer research is the development of selective, specific, and patient-tailored drugs to minimize unnecessary side effects and risks to patients. In order to achieve this, understanding the biology of the different classes of breast cancer is necessary, and will lead to the identification of potential drug targets (such as 14-3-3sigma) for future research. The proposed experiments aim to fundamentally understand the biology of breast cancer progression, and to validate 14-3-3sigma as a potential “druggable” target to stop cancer progression.
Merian-Forcart, Jean
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Basel
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Looking through words
Creators: name: Jacob, Nellickal Abraham
Publisher: name: No Publisher Supplied
Year: 2012

description: “Looking Through Words” explores the intersection of the literary and the visual inthe nineteenth century—a period distinguished by an unprecedented investment in new visual technologies that created and fed the demand for mechanically produced images in an increasingly lucrative visual culture. But alongside this exponential increase in specular technologies, which seemed to release the image from intentional control, the nineteenth century was also witness to a range of intellectual developments that relocated the idea of sight to an increasingly psychologized register of mental images. Literature in the nineteenth-century represents an important venue for the elaborationand mediation of the high stakes involved in this partitioning of the visual image. Even while marking its distance from the exponential growth in technologies of commercial reproduction, literature finds itself frequently engaged with the idea of visual image. My dissertation is about the enduring drive within the literary to re-visit this breach in the idea of the visual. It tracks four different literary engagements with the modalities of this internal division over the course of the nineteenth century. While the first chapter examines the unique word-picture experiments of Blake’s illuminated poetry, the second analyzes Shelley’s ekphrastic poem “On the Medusa of Leonardo Da Vinci” and places itagainst the broader canvas of Romantic ekphrastic poetry. The third chapter places Oscar Wilde’s The Picture of Dorian Gray alongside nineteenth-century photography and explores the novel’s discursive engagement with the legal debates on copyright and authorship occasioned by the advent of photography. My final chapter extends this analysis of literature and photography through an examination of the magic-picture tradition—a literary sub-genre consisting primarily of short fictional texts preoccupied with paintings or photographs that behave out of character. In all four chapters the visual is the site of a conceptual turbulence that occasions a re-negotiation of the modalities through which real and imagined images inhabit literary forms.
Schneider, Martin, Bezirksschreiber
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Gelterkinden
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Scaptomyza vittata Coquillett 1895
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Scaptomyza
Scaptomyza vittata

description: vittata (Coquillett), 1895:318 (Drosophila). Type locality: USA, Florida, Charlotte Harbor. HT M not in USNM. NT. Distr.: Mississip, Maryland to Florida, Mexico, Colombia. Ref. Wheeler & Takada 1966: 43; Brncic 1983: 72.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 736, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Finding BRCA1 Ubiquitinated Substrates by Protein Microarray
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: This project was originated by Dr. Sonia del Rincon and was completed by Dr. Charles Spruck.

 Women that inherit a mutated BRCA1 gene have a lifetime risk of 36-85% for developing breast cancer. One of BRCA1’s tasks is “tagging” other proteins with a small protein, called ubiquitin. This task is called “ubiquitination”, a general cellular process that controls the stability, function, and intracellular localization of a wide variety of proteins. The most typical function of ubiquitin is labeling proteins for proteasomal degradation. Thus, BRCA1 is a critical ubiquitin ligase enzyme within cells. Interestingly, several inherited BRCA1 gene mutations prevent it from ubiquitinating proteins, suggesting the importance of this task in protecting breast epithelial cells from becoming cancerous.

 Currently, little is known regarding how loss of BRCA1’s ubiquitin ligase function contributes to breast cancer development and this has primarily been due to an inability of researchers to identify the proteins tagged by BRCA1. We have developed a novel experimental method that allows us to identify proteins that become tagged with ubiquitin. Protein microarrays are glass slides that are spotted with more than 8000 human proteins as separate tiny “dots.” Some of these spotted proteins can become tagged by ubiquitin when the entire glass slide is overlaid with a biochemical reaction mix that includes a purified BRCA1 ubiquitin ligase. Once we have identified the specific proteins that are ubiquitinated, we will then use cell-based models for validation. Finally, we will use primary breast tumor samples derived from women that carry BRCA1 mutations to look at the biological outcomes associated when a specific protein is not ubiquitinated properly, thus giving insight into BRCA1-dependent processes that go awry in breast cancer.

 If our studies are successful, we will be in a unique position to pinpoint what goes wrong when BRCA1 fails to function properly. This knowledge might ultimately be used to develop less radical breast cancer prevention strategies, other than bilateral mastectomies, for women harboring inherited BRCA1 mutations.
Proline metabolism in metastatic breast cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Increased glucose consumption is perhaps the most common phenotype of tumorigenic cells. Although we know that the metabolic program of human tumor cells is critically important to malignant tumors, the molecular details of human tumor metabolic program remain largely unknown. Previously, we studied the changes that occur to glucose metabolic pathways as breast cells become increasingly invasive and them metastatic. Based upon these and other results, we suspect that the proline (one of 20 DNA-encoded amino acids) biosynthetic pathway is a key mediator of breast tumor cell metastasis.

 Using IDEA grant funding from CBCRP we will test our hypothesis that altered breast tumor cell proline metabolism is associated mechanistically with metastasis. We will specifically test:

 1) To what extent does proline biosynthesis increase metastasis?

 2) Does increased proline biosynthesis or an increased cellular proline pool suppress apoptosis and allow breast tumor cells to migrate?

 Our experimental approach is based on and utilizes stable isotope labeling, an uncommon but extremely informative branch of metabolomics (i.e., the collection of all metabolites in a cell or organism). By growing human breast tumor cells in the presence of 13C-glucose (which is indistinguishable from 12C-glucose on a cellular level, but more readily observed) we are able to determine not only the relative amounts of metabolites but the rates at which they were produced. We will use this technique to measure proline biosynthetic rates in human cells following gene silencing or over-expression, and in mouse models of metastasis. The importance of proline biosynthesis in metastasis will be tested in a series of human breast cells, derived from the same patient sample, that range from completely non-tumorigenic (normal control) to invasive to metastatic.

 While it is well documented that breast cancer cells shift their global metabolic programs, the exact role of these metabolic shifts in tumor invasion and metastasis remains undefined. Determination of the activity of the metabolic program in addition to the expression level of the enzymatic components will describe an important aspect of the breast tumor phenotype and potentially allow us to design therapies that inhibit tumor cell movement. This study will significantly contribute both to our knowledge of metabolic changes associated with the metastatic phenotype in breast cancer, and to the development of anti-metastatic therapies for breast cancer.
title: New methods for parameterization of Distributed Mode Loudspeakers
Creators: name: Czesak, Karol
name: Kleczkowski, Piotr
Publisher: name: Poznań University of Technology
publisherIdentifier: https://ror.org/00p7p3302
publisherIdentifierScheme: ROR
Year: 2024

description: Vibrations in Physical Systems, 35(3), 2024315-1 - 2024315-12
Meiner, Borneque & Co
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Forge de Bellefontaine
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Seeligmann, Aron
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Karlsruhe
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Levy, Moyse
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Belfort
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Scaptomyza wheeleri Hackman 1959
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Scaptomyza
Scaptomyza wheeleri

description: wheeleri Hackman, 1959: 49. Type locality: USA, Virginia, Falls Church. HT M (USNM). NT NE Distr.: Tennessee to Virginia, s. to Florida, Mexico to Ecuador. Refs.: Wheeler & Takada, 1966: 43.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 736, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Lichtenhahn & Buxtorf
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Basel
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Kisling & Co
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Mannheim
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Levy, Vater
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Cernay
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Scaptomyza spinipalpis Seguy 1934
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Scaptomyza
Scaptomyza spinipalpis

description: spinipalpis Séguy, 1934: 11. Type locality: Argentina, La Plata. T M MNHNP?. NT Distr.: Argentina, Bolivia, Colombia. Refs.: Wheeler & Takada, 1966: 43.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 737, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Leali, Assecuratori
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Livorno
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Krick, Joseph
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Strassburg
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Faesy, Georg Heinrich
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Eichthal bei Zürich
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Scaptomyza andina Wheeler & Takada 1966
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Scaptomyza
Scaptomyza andina

description: andina Wheeler & Takada, 1966: 43. Type locality: Colombia, 11 km E Bogotá, in wasteland on road to Choachi. HT M (USNM). NT Distr.: Colombia, Ecuador.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 737, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Low, Daniel
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Paris
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Tissue-resident Memory T cells and HIV Latency in the Gut
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: In most developed countries, highly active antiretroviral therapy has transformed HIV infection into a manageable chronic disease. Despite systemic viral suppression, however, HIV survives, and patients continue to suffer from non-AIDS morbidities. The main barrier to eradication is a small proportion of latently infected cells that harbor the virus in a form that is invisible to the immune system and protected from the effects of antiretroviral drugs. As these cells reactivate over time, the latent reservoir continues to cause residual immune activation and chronic systemic inflammation. The increased inflammation contributes to a higher incidence of cardiovascular disease, certain cancers, cognitive and renal impairment, bone demineralization, and immune dysregulation. One of the main sites for latent and productively infected cells is the gut. During acute infection, HIV initiates a vicious inflammatory cycle by causing damage to the mucosal barrier of the gut, leading to systemic exposure to microbial products and increased activation of T cells. Since disruption of the mucosal barrier is a key contributor to the excess inflammation, it is critical to better identify latently and productively infected cells in the gut to specifically target and eliminate them. However, the HIV reservoir in the gut is poorly understood, in part because of the difficulty of obtaining gut biopsies. Moreover, the gut contains resident memory T cells with unique functional, phenotypic, and survival properties that are distinct from those in lymphoid tissues and blood. We propose to isolate various memory populations from gut biopsies of HIV-positive patients and healthy controls and use highly sensitive methods to determine which memory population harbors the most latent and productive HIV. To better understand factors that promote latency or viral replication, we will also analyze global gene expression in these cell populations and determine how the gut microenvironment contributes to their long-term survival. Understanding the mechanisms by which the gastrointestinal niche contributes to the maintenance of latently infected cells will provide knowledge required to develop therapies to eliminate the HIV reservoir in the gut. The ultimate goal is to repair mucosal barrier function and decrease systemic inflammation, with the hope of restoring normal health and reducing comorbidities in HIV-positive patients.
Drosophila flava Fallen 1823
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Drosophila
Drosophila flava

description: flava (Fallen), 1823: 7 (Drosophila). Type locality: Sweden, Kristianstad, Äsperoöd (=Esperöd). LT F ZIL (lost). HT M (AMNH). NE PA OR NT AF AU Distr.: cosmopolitan. Refs.: Becker, 1919.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 737, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Koechlin, Nicolas, & Frères
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Mulhouse
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Luden & Poel
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Amsterdam
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Effects of growth hormone on human thymopoiesis
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: LAY ABSTRACT HIV impairs the immune system by infecting and destroying T cells. Unfortunately, T cells are not easily replaced after being destroyed by HIV. The thymus gland – the primary site of T-cell development – involutes after childhood and has been assumed to be inactive in adults. The production of new T cells is therefore greatly reduced in adults, making it especially difficult for HIV-infected adults to rebuild their immune system. Thus, a therapeutic role may be found for agents that stimulate the thymus to produce T cells during HIV infection. Recent studies from our group challenge the assumption that the thymus cannot be reactivated in human adults. Based upon promising animal studies suggesting that growth hormone (GH) enhances thymic function, we conducted a small study that led to the exciting observation that GH appears to reverse thymic involution and facilitate immune reconstitution in HIV-infected adults. Despite its clinical promise, the mechanisms of GH action remain unclear. GH effects on the thymus could be induced directly by GH or indirectly through the GH companion hormone insulin-like growth factor-1 (IGF-1). The overall objective of this proposal is to identify GH and IGF-1 targets within the thymus and to provide a comprehensive analysis of changes in the human thymus in response to administration of GH and IGF-1. If successful, this information would be directly applicable to the development of targeted therapies to enhance T-cell production in immunodeficient individuals.
Lutz & Naeff
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Rheineck
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Lajeune, Philippe
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: New York
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Falconnet & Co
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Neapel
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Scaptomyza neoandina Wheeler & Takada 1966
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Scaptomyza
Scaptomyza neoandina

description: neoandina Wheeler & Takada, 1966: 48. Type locality: Colombia, 11 km E Bogotá, in paramos on road to Choachi. HT M (AMNH). NT Distr.: Colombia.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 737, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Loeffler, Charles
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Messina
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Schleswig-Holstein meerumschlungen and the call for nationalism
Creators: name: Jacobsen, Juljana Gjata Hjorth
Publisher: name: No Publisher Supplied
Year: 2012

description: My dissertation examines selected German and Danish literary texts of the latenineteenth century that employ ideological notions of nationalism for the purpose ofconstructing and stabilizing national identity. The groundwork for the research centers onspecific times in nationalist movements in Europe and a specific setting on the borderregion of Schleswig-Holstein. The urgency of this project lies especially in the effort tounderstand the shifting qualities and perceptions of nationalism as both a destructive andproductive force in current discourses of globalization. In my analysis of four literary narratives, Theodor Storm’s novellas Ein grünes Blatt (1850) and Abseits (1863), Theodor Fontane’s Unwiederbringlich (1891), and Herman Bang’s Tine (1889), I demonstrate how national identity is constructed on the basis of a firm nationalism and constantly destabilized when confronted with the presence of an Other by the border. In the chosen literary works, national identity, at all stages of its formation and in all classifications and depictions as German, Prussian, Danish, or Frisian, is fundamentally about attaining the subject’s recognition as sovereign and universal. And because the subject functions as a representation of the nation with which it identifies, the construction of the subject’s national identity is ultimately about achieving international recognition. In the selected narratives, national identity—whether German or Danish—is constructed by the authors in a very similar fashion. While nationalism is criticized and condemned to different degrees, it also serves as the necessary ground for shaping effectively one’s national identity. The three authors under discussion operate with a nationalist project in which they set out to construct a national self: in the texts under consideration, nationalism functions as a temporary but necessary formative stage in the construction of the subject’s national identity. The selected authors also experience and triumph over nationalism in their personal lives. Ultimately, this dissertation will point to the crucial significance of the regional particularity—given by the margins of a border area—for the representation of the national totality.
Scaptomyza parandina Wheeler & Takada 1966
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Scaptomyza
Scaptomyza parandina

description: parandina Wheeler & Takada, 1966: 50. Type locality: Colombia, Bogotá area, 10000 ft. HT M (USNM). NT Distr.: Colombia.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 737, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Lynen, Henry, & Peltzer
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Paris
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Lindauer, Franz
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: München
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
HIV-1 Vif Interactions with APOBEC3G
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: A cellular enzyme, termed APOBEC3G (A3G), forms a powerful defense against several retroviruses, including, under certain conditions, HIV. HIV encodes a factor, Vif, whose role is to prevent incorporation of A3G into HIV virions. The mechanism by which Vif counters A3G virion incorporation is believed to involve targeting of A3G for destruction by the cell, in a complex termed the proteasome, although this has been debated in the field. In the absence of Vif, A3G incorporation into virions ultimately results in hypermutation of the viral genome, effectively abrogating viral growth and spread. However, Vif only acts later in the HIV lifecycle, when new virions are being produced. Upon initial infection of a cell by HIV, Vif is barely present, thus leaving A3G free of any counterattack by Vif. Curiously, the ability of A3G to attack the viral genome at this stage depends on the form in which it resides in the cell. In cells identified as “resting CD4 T cells”, A3G resides as a low molecular mass (LMM) form that effectively blocks viral replication and these cells do not support HIV growth. In contrast, in “activated CD4 T cells” A3G forms high molecular mass (HMM) complexes that fail to block viral replication; these cells are the major targets for HIV infection. Upon synthesis, A3G is LMM but is rapidly recruited into HMM complexes within 30 minutes. Importantly, only the newly synthesized LMM A3G is recruited into HIV-1 virions for once assembled into the HMM complex, A3G no longer forms a supply for virion incorporation. Thus, Vif must target newly synthesized, LMM A3G, in order to prevent its incorporation into virions. I thus propose (1) to determine how Vif targets newly synthesized A3G and whether prevention of virion incorporation of LMM A3G is mediated by proteasome-dependent degradation, and (2) to assess whether Vif binding to LMM A3G impairs virion incorporation by a non-proteasome-dependent mechanism and whether Vif binding inhibits the intrinsic enzymatic activity of LMM A3G. Deciphering the precise mechanism by which Vif neutralizes the biologically relevant LMM form of A3G that is incorporated into virions could impact ongoing drug discovery efforts aimed at preserving virion encapsidation of A3G and the resultant potent antiviral action of this host factor.
La Roche, Emanuel, Sohn
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Basel
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Scaptomyza subandina Wheeler & Takada 1966
Creators: name: Tidon, Rosana
name: Almeida, Jonathan Mendes De
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Scaptomyza
Scaptomyza subandina

description: subandina Wheeler & Takada, 1966: 50. Type locality: Colombia, Bogotá area, 17 km S Usme, 11000 ft. HT M (USNM). NT Distr.: Colombia.
description: Published as part of Tidon, Rosana & Almeida, Jonathan Mendes De, 2016, FAMILY DROSOPHILIDAE, pp. 719-751 in Zootaxa 4122 (1) on page 737, DOI: 10.11646/zootaxa.4122.1.63, http://zenodo.org/record/263272
Levy, Baruch
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Strassburg
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Fehr, E. & J. A
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1833

description: Ort: Philadelphia
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert