cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
TBCRC 018: phase II study of iniparib in combination with irinotecan to treat progressive triple negative breast cancer brain metastases
Creators: name: Melisko, Michelle
name: Storniolo, Anna M.
name: Stearns, Vered
name: Abramson, Vandana
name: Parker, Joel
name: Van Poznak, Catherine
name: Puhalla, Shannon
name: Berg, Jonathan
name: Peterman, Amy
name: Carey, Lisa A.
name: Deal, Allison M.
name: Winer, Eric P.
name: Smith, J. Keith
name: Lin, Nancy U.
name: Liu, Minetta C.
name: Perou, Charles M.
name: Karginova, Olga
name: Carpenter, John T.
name: Anders, Carey
name: Prat, Aleix
name: Kelly Marcom, P.
name: Melhem-Bertrandt, Amal
name: Nanda, Rita
name: Wolff, Antonio C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Nearly half of patients with advanced triple negative breast cancer (TNBC) develop brain metastases (BM) and most will also have uncontrolled extracranial disease. This study evaluated the safety and efficacy of iniparib, a small molecule anti-cancer agent that alters reactive oxygen species tumor metabolism and penetrates the blood brain barrier, with the topoisomerase I inhibitor irinotecan in patients with TNBC-BM. Eligible patients had TNBC with new or progressive BM and received irinotecan and iniparib every 3weeks. Time to progression (TTP) was the primary end point; secondary endpoints were response rate (RR), clinical benefit rate (CBR), overall survival (OS), toxicity, and health-related quality of life. Correlative endpoints included molecular subtyping and gene expression studies on pre-treatment archival tissues, and determination of germline BRCA1/2 status. Thirty-seven patients began treatment; 34 were evaluable for efficacy. Five of 24 patients were known to carry a BRCA germline mutation (4 BRCA1, 1 BRCA2). Median TTP was 2.14months and median OS was 7.8months. Intracranial RR was 12%, while intracranial CBR was 27%. Treatment was well-tolerated; the most common grade 3/4 adverse events were neutropenia and fatigue. Grade 3/4 diarrhea was rare (3%). Intrinsic subtyping revealed 19 of 21 tumors (79%) were basal-like, and intracranial response was associated with high expression of proliferation-related genes. This study suggests a modest benefit of irinotecan plus iniparib in progressive TNBC-BM. More importantly, this trial design is feasible and lays the foundation for additional studies for this treatment-refractory disease.Electronic supplementary materialThe online version of this article (doi:10.1007/s10549-014-3039-y) contains supplementary material, which is available to authorized users.
title: Pediatric elbow trauma: The injuries not to be missed
Creators: name: Cristiano, Lara
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Trauma
subject: Education and training
subject: Acute
subject: Education
subject: Ultrasound
subject: Plain radiographic studies
subject: CT
subject: Trauma
subject: Paediatric
subject: Bones

description: Learning objectives Background Imaging findings OR Procedure Details Conclusion References Personal Information
description: Learning objectives: The aim of this study is to describe a small group of pediatric elbow injuries, which can be easily missed on plain films, because of their benign apperance, expecially in the youngest children with prevalent cartilage...
Body mass index associated with genome-wide methylation in breast tissue
Creators: name: Conway, Kathleen
name: Robinson, Whitney R.
name: Hair, Brionna Y.
name: Kirk, Erin L.
name: Taylor, Jack A.
name: Sandhu, Rupninder
name: Troester, Melissa A.
name: Olshan, Andrew F.
name: Harlid, Sophia
name: Wu, Michael C.
name: Xu, Zongli
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Gene expression studies indicate that body mass index (BMI) is associated with molecular pathways involved in inflammation, insulin-like growth factor activation, and other carcinogenic processes in breast tissue. The goal of this study was to determine whether BMI is associated with gene methylation in breast tissue and to identify pathways that are commonly methylated in association with high BMI. Epigenome-wide methylation profiles were determined using the Illumina HumanMethylation450 BeadChip array in the non-diseased breast tissue of 81 women undergoing breast surgery between 2009 and 2013 at the University of North Carolina Hospitals. Multivariable, robust linear regression was performed to identify methylation sites associated with BMI at a false discovery rate q value <0.05. Gene expression microarray data was used to identify which of the BMI-associated methylation sites also showed correlation with gene expression. Gene set enrichment analysis was conducted to assess which pathways were enriched among the BMI-associated methylation sites. Of the 431,568 methylation sites analyzed, 2573 were associated with BMI (q value <0.05), 57 % of which showed an inverse correlation with BMI. Pathways enriched among the 2573 probe sites included those involved in inflammation, insulin receptor signaling, and leptin signaling. We were able to map 1251 of the BMI-associated methylation sites to gene expression data, and, of these, 226 (18 %) showed substantial correlations with gene expression. Our results suggest that BMI is associated with genome-wide methylation in non-diseased breast tissue and may influence epigenetic pathways involved in inflammatory and other carcinogenic processes.
title: Visibility and Evaluation of Anterolateral Ligament Tears in Patients with Anterior Cruciate Ligament Rupture with Magnetic Resonance Imaging
Creators: name: Yan, Yet Yen
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Athletic injuries
subject: Imaging sequences
subject: MR
subject: Trauma
subject: Musculoskeletal system
subject: Musculoskeletal joint

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: Anterolateral ligament (ALL) tears are known to be associated with anterior cruciate ligament (ACL) tears. However, there is little literature correlating the visibility of the site of the ALL tear with the timing of knee magnetic resonance imaging...
Condensation in models with factorized and pair-factorized stationary states
Creators: name: Evans, M. R.
name: Waclaw, B.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Non-equilibrium real-space condensation is a phenomenon in which a finite fraction of some conserved quantity (mass, particles, etc.) becomes spatially localised. We review two popular stochastic models of hopping particles that lead to condensation and whose stationary states assume a factorized form: the zero-range process and the misanthrope process, and their various modifications. We also introduce a new model - a misanthrope process with parallel dynamics - that exhibits condensation and has a pair-factorized stationary state.
description: 15 pages, 2 figures submitted to J. Stat. Mech
แนวทางการพัฒนาทรัพยากรมนุษย์ของบุคลากรสังกัดเทศบาลในเขตอำเภอแก้งคร้อ จังหวัดชัยภูมิ
Creators: name: มานะชัย เทพสุรินทร์
Publisher: name: มหาวิทยาลัยมหาจุฬาลงกรณราชวิทยาลัย วิทยาเขตนครสวรรค์
Year: 2022
Subjects: การพัฒนา
ทรัพยากรมนุษย์
บุคลากรสังกัดเทศบาล

description: The Journal of Research and Academics, 5, 5, 127-142
Chemotherapy-related amenorrhea after adjuvant paclitaxel–trastuzumab (APT trial)
Creators: name: Shapira, Iuliana
name: Burstein, Harold J.
name: Carey, Lisa A.
name: Wolff, Antonio C.
name: Tolaney, Sara M.
name: Marcom, P. Kelly
name: Winer, Eric P.
name: Partridge, Ann H.
name: Dang, Chau T.
name: Moy, Beverly
name: Yardley, Denise A.
name: Guo, Hao
name: Hudis, Clifford
name: Ruddy, Kathryn J.
name: Ellis, Matthew J.
name: Barry, William
name: Krop, Ian E.
name: Rugo, Hope S.
name: Overmoyer, Beth A.
name: Albain, Kathy S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Chemotherapy-related amenorrhea (CRA) is associated with infertility and menopausal symptoms. Learning how frequently paclitaxel and trastuzumab cause amenorrhea is important. Most other adjuvant breast cancer therapies induce CRA in approximately 50% of all premenopausal recipients [1].
title: The Buffalo Hump: Sonographic differentiation of a prominent dorsocervical fat pad from lipoma
Creators: name: Lo, Wai Keung
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Musculoskeletal soft tissue
subject: Ultrasound
subject: Diagnostic procedure
subject: Technical aspects
subject: AIDS
subject: Metabolic disorders

description: Learning objectives Background Imaging findings OR Procedure Details Conclusion References Personal Information
description: Learning objectives: To become familiar with the sonographic appearance of a dorsocervical fat pad and a lipoma, both of which could masquerade as a Buffalo hump. To recognize a role of ultrasound in such differentiation and channeling appropriate...
Barjols, place de la Rouguière, mazurka dansée par le groupe folklorique La Caleur
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2024

Abstract
A General Hidden State Random Walk Model for Animal Movement
Creators: name: Nicosia, Aurélien
name: Duchesne, Thierry
name: Rivest, Louis-Paul
name: Fortin, Daniel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: In this paper, we propose a general hidden state random walk model to describe the movement of an animal that takes into account movement taxis with respect to features of the environment. A circular-linear process models the direction and distance between two consecutive localizations of the animal. A hidden process structure accounts for the animal's change in movement behavior. The originality of the proposed approach is that several environmental targets can be included in the directional model. An EM algorithm is devised to fit this model and an application to the analysis of the movement of caribou in Canada's boreal forest is presented
description: 28 pages
Capture-recapture abundance estimation using a semi-complete data likelihood approach
Creators: name: King, Ruth
name: McClintock, Brett T.
name: Kidney, Darren
name: Borchers, David
Publisher: name: arXiv
Year: 2015
Subjects: subject: Methodology (stat.ME)
subject: Quantitative Methods (q-bio.QM)
subject: FOS: Computer and information sciences
subject: FOS: Biological sciences

description: Capture-recapture data are often collected when abundance estimation is of interest. In the presence of unobserved individual heterogeneity, specified on a continuous scale for the capture probabilities, the likelihood is not generally available in closed form, but expressible only as an analytically intractable integral. Model-fitting algorithms to estimate abundance most notably include a numerical approximation for the likelihood or use of a Bayesian data augmentation technique considering the complete data likelihood. We consider a Bayesian hybrid approach, defining a "semi-complete" data likelihood, composed of the product of a complete data likelihood component for individuals seen at least once within the study and a marginal data likelihood component for the individuals not seen within the study, approximated using numerical integration. This approach combines the advantages of the two different approaches, with the semi-complete likelihood component specified as a single integral (over the dimension of the individual heterogeneity component). In addition, the models can be fitted within BUGS/JAGS (commonly used for the Bayesian complete data likelihood approach) but with significantly improved computational efficiency compared to the commonly used super-population data augmentation approaches (between about 10 and 77 times more efficient in the two examples we consider). The semi-complete likelihood approach is flexible and applicable to a range of models, including spatially explicit capture-recapture models. The model-fitting approach is applied to two different datasets corresponding to the closed population model $M_h$ for snowshoe hare data and a spatially explicit capture-recapture model applied to gibbon data.
title: Peri-implant fractures in patients with intramedullary femoral nail: Radiological study of the lesser trochanter.
Creators: name: Salinaro, Emanuela
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Trauma
subject: Prostheses
subject: Biological effects
subject: Treatment effects
subject: Surgery
subject: Plain radiographic studies
subject: Digital radiography
subject: Trauma
subject: Musculoskeletal bone
subject: Extremities

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: The use of intramedullary nail has become a standard for the treatment of intertrochanteric fractures. The technique is minimally invasive and effective, allowing early weight bearing in order to preserve independence as long as...
CIB1 depletion impairs cell survival and tumor growth in triple-negative breast cancer
Creators: name: George, Samuel D.
name: Leisner, Tina M.
name: Black, Justin L.
name: Harrell, J. Chuck
name: Jones, Corbin D.
name: Parise, Leslie V.
name: Perou, Charles M.
name: Fellmeth, Melissa J.
name: Der, Channing J.
name: Reinhold, Dominik
name: Baker, Nicole M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with generally poor prognosis and no available targeted therapies, highlighting a critical unmet need to identify and characterize novel therapeutic targets. We previously demonstrated that CIB1 is necessary for cancer cell survival and proliferation via regulation of two oncogenic signaling pathways, RAF–MEK–ERK and PI3K–AKT. Because these pathways are often upregulated in TNBC, we hypothesized that CIB1 may play a broader role in TNBC cell survival and tumor growth. Methods utilized include inducible RNAi depletion of CIB1 in vitro and in vivo, immunoblotting, clonogenic assay, flow cytometry, RNA-sequencing, bioinformatics analysis, and Kaplan–Meier survival analysis. CIB1 depletion resulted in significant cell death in 8 of 11 TNBC cell lines tested. Analysis of components related to PI3K–AKT and RAF–MEK–ERK signaling revealed that elevated AKT activation status and low PTEN expression were key predictors of sensitivity to CIB1 depletion. Furthermore, CIB1 knockdown caused dramatic shrinkage of MDA-MB-468 xenograft tumors in vivo. RNA sequence analysis also showed that CIB1 depletion in TNBC cells activates gene programs associated with decreased proliferation and increased cell death. CIB1 expression levels per se did not predict TNBC susceptibility to CIB1 depletion, and CIB1 mRNA expression levels did not associate with TNBC patient survival. Our data are consistent with the emerging theory of non-oncogene addiction, where a large subset of TNBCs depend on CIB1 for cell survival and tumor growth, independent of CIB1 expression levels. Our data establish CIB1 as a novel therapeutic target for TNBC.
Barjols, place de la Rouguière, arrivée des chevaux et des cavaliers de la Nation gardianne
Creators: name: Musée National Des Arts Et Traditions Populaires (Paris)
name: Centre D'ethnologie Française
Publisher: name: École des Hautes Études en Sciences Sociales; Institut  interdisciplinaire d'anthropologie du contemporain (Paris); Laboratoire d'anthropologie et d'histoire de l'institution de la culture (Paris)
Year: 2024

Abstract
Superconductivity protected by spin-valley locking in ion-gated MoS2
Creators: name: Saito, Yu
name: Nakamura, Yasuharu
name: Bahramy, Mohammad Saeed
name: Kohama, Yoshimitsu
name: Ye, Jianting
name: Kasahara, Yuichi
name: Nakagawa, Yuji
name: Onga, Masaru
name: Tokunaga, Masashi
name: Nojima, Tsutomu
name: Yanase, Youichi
name: Iwasa, Yoshihiro
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Symmetry-breaking has been known to play a key role in noncentrosymmetric superconductors with strong spin-orbit-interaction (SOI). The studies, however, have been so far mainly focused on a particular type of SOI, known as Rashba SOI, whereby the electron spin is locked to its momentum at a right-angle, thereby leading to an in-planar helical spin texture. Here we discuss electric-field-induced superconductivity in molybdenum disulphide (MoS2), which exhibits a fundamentally different type of intrinsic SOI manifested by an out-of-plane Zeeman-type spin polarization of energy valleys. We find an upper critical field of approximately 52 T at 1.5 K, which indicates an enhancement of the Pauli limit by a factor of four as compared to that in centrosymmetric conventional superconductors. Using realistic tight-binding calculations, we reveal that this unusual behaviour is due to an inter-valley pairing that is symmetrically protected by Zeeman-type spin-valley locking against external magnetic fields. Our study sheds a new light on the interplay of inversion asymmetry with SOI in confined geometries, and its unprecedented role in superconductivity.
description: 37 pages, 11 figures, http://meetings.aps.org/Meeting/MAR15/Session/G11.11
Cross-species DNA copy number analyses identifies multiple 1q21-q23 subtype-specific driver genes for breast cancer
Creators: name: Carey, Lisa A.
name: Perou, Charles M.
name: Parker, Joel S.
name: Ma, Jian
name: Silva, Grace O.
name: Moulder, Stacy L.
name: Hou, Jack P.
name: Marcom, Paul K.
name: Gatza, Michael L.
name: Rosen, Jeffrey M.
name: He, Xiaping
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: A large number of DNA copy number alterations (CNAs) exist in human breast cancers, and thus characterizing the most frequent CNAs is key to advancing therapeutics because it is likely that these regions contain breast tumor ‘drivers’ (i.e., cancer causal genes). This study aims to characterize the genomic landscape of breast cancer CNAs and identify potential subtype-specific drivers using a large set of human breast tumors and genetically engineered mouse (GEM) mammary tumors. Using a novel method called SWITCHplus, we identified subtype-specific DNA CNAs occurring at a 15% or greater frequency, which excluded many well-known breast cancer-related drivers such as amplification of ERBB2, and deletions of TP53 and RB1. A comparison of CNAs between mouse and human breast tumors identified regions with shared subtype-specific CNAs. Additional criteria that included gene expression-to-copy number correlation, a DawnRank network analysis, and RNA interference functional studies highlighted candidate driver genes that fulfilled these multiple criteria. Numerous regions of shared CNAs were observed between human breast tumors and GEM mammary tumor models that shared similar gene expression features. Specifically, we identified chromosome 1q21-23 as a Basal-like subtype-enriched region with multiple potential driver genes including PI4KB, SHC1, and NCSTN. This step-wise computational approach based on a cross-species comparison is applicable to any tumor type for which sufficient human and model system DNA copy number data exist, and in this instance, highlights that a single region of amplification may in fact harbor multiple driver genes.Electronic supplementary materialThe online version of this article (doi:10.1007/s10549-015-3476-2) contains supplementary material, which is available to authorized users.
title: Alkaptouria: Clinical, radiological and biochemical assessment
Creators: name: Alberotanza, Vito
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Metabolic disorders
subject: Comparative studies
subject: Plain radiographic studies
subject: MR
subject: Musculoskeletal spine

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: To compare the spine alterations in alkaptonuria with traditional radiology and MRI, to a correct diagnosis of the disease, its sequel and, so, the timing and the type of...
Hormone-related pathways and risk of breast cancer subtypes in African American women
Creators: name: Hong, Chi Chen
name: Lunetta, Kathryn L.
name: Troester, Melissa A.
name: Bensen, Jeannette T.
name: Sucheston-Campbell, Lara E.
name: Ruiz-Narváez, Edward A.
name: Yao, Song
name: Haiman, Christopher A.
name: Palmer, Julie R.
name: Rosenberg, Lynn
name: Ambrosone, Christine B.
name: Bandera, Elisa V.
name: Haddad, Stephen A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: We sought to investigate genetic variation in hormone pathways in relation to risk of overall and subtype-specific breast cancer in women of African ancestry (AA).
title: The use of variable engine geometry to improve the transient performance of a two-spool turbofan engine
Creators: name: Boumedmed, Abdelkader
Publisher: name: University of Glasgow
Year: 1997
Subjects: subject: Mechanical engineering, aerospace engineering.

description: The prediction of the behaviour of a two-spool turbofan engine (Tay Mk610) under steady-running and during transient performances has been carried out in the present investigation. Four different variable geometry features have been investigated with a view to achieving surge-free acceleration and deceleration of the engine. These are: altering the scheduling of the Inlet Guide Vanes (IGVs) of the High Pressure (H.P.) compressor, altering the Handling Bleed Valve schedule in the H.P. compressor, bleeding some air from the I.P. compressor delivery into the Bypass Duct of the engine, and finally altering the throat area of the Final Nozzle of the engine. The method of the Inter Component Volumes has been adopted for the performance prediction. The simulation prediction, for the 'Design' engine, has been based upon the real characteristics of the engine components and engine data provided by the manufacturer, thus the simulation prediction is realistic. These characteristics used for this 'Design' engine are the characteristics used by the manufacturer in the original design of the engine - thus the H.P. compressor IGVs and Handling Bleed Valve move in accordance with the 'Design' schedules. With regard to the effects on steady-running and transient performances of heat transfer, for simplicity these have been ignored, i.e. the systems are regarded as being adiabatic. The predicted transient trajectories, for reasonable thrust response rates, are satisfactory in all compressors with the comments that (a) in the acceleration there is a condition in the H.P. compressor near to surge at (NH/T26) of about 548, (b) in the deceleration there is an approach towards surge in the I.P. compressor over the band (NL/T26) 433 to 340. Characteristics of the H.P. compressor (of 12 stages) are required for the situations with modified IGV and Handling Bleed schedules. Little information on this was available from the manufacturer. An existing programme, of the row by row type, for predicting axial flow compressor characteristics has been developed and used, along with the sparse engine manufacturer's data, to predict the changes in characteristics resulting from altered IGV and Handling Bleed schedules. (Abstract shortened by ProQuest.).
title: Non traumatic myositis ossificans.
Creators: name: Alberotanza, Vito
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Diagnostic procedure
subject: MR
subject: Musculoskeletal soft tissue
subject: Inflammation

description: Learning objectives Background Imaging findings OR Procedure Details Conclusion References Personal Information
description: Learning objectives: Non traumatic myositis ossificans is benign non neoplastic condition, carachterized by ectopic development of bone tissue in muscle fibers. There is an increased activity of periarticular tissues resulting in intramuscular bone formation. In most of...
Connecting researchers, developers and citizen scientists in a unique mobile app environment.
Creators: name: Schmidt, Norbert
name: Giuffrida, Maria
name: Willems, Marieke
name: Justamante Rodríguez, Ángela
Publisher: name: Zenodo
Year: 2022
Subjects: data
app
sensor
citizen science
citizen observatory
mobile
EOSC in Practice
cross-disciplinary

description: This EOSC in practice story targets three main types of users: (1) the citizen and citizen scientists who collect valuable data, (2) the researchers who use and benefit from the data collected by citizens via smartphones and sensors, and (3) software developers. The service presented is called MOBIS, developed by DDQ: Pocket Science , a small Dutch company specialised in the development of mobile-based (citizen-) science applications with research partners worldwide. Such solution aims at solving the problem of high fragmentation in the citizen science apps ecosystem offering an integration service. The service is available on the EOSC Portal Catalogue and Marketplace and was developed within the Cos4Cloud Project. The full list of EOSC in practice stories is available here
Luminal progenitor and fetal mammary stem cell expression features predict breast tumor response to neoadjuvant chemotherapy
Creators: name: Pfefferle, Adam D.
name: Spike, Benjamin T.
name: Perou, Charles M.
name: Wahl, Geoff M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Mammary gland morphology and physiology are supported by an underlying cellular differentiation hierarchy. Molecular features associated with particular cell types along this hierarchy may contribute to the biological and clinical heterogeneity observed in human breast carcinomas. Investigating the normal cellular developmental phenotypes in breast tumors may provide new prognostic paradigms, identify new targetable pathways, and explain breast cancer subtype etiology. We used transcriptomic profiles coming from fluorescence-activated cell sorted (FACS) normal mammary epithelial cell types from several independent human and murine studies. Using a meta-analysis approach, we derived consensus gene signatures for both species and used these to relate tumors to normal mammary epithelial cell phenotypes. We then compiled a dataset of breast cancer patients treated with neoadjuvant anthracycline and taxane chemotherapy regimens to determine if normal cellular traits predict the likelihood of a pathological complete response (pCR) in a multivariate logistic regression analysis with clinical markers and genomic features such as cell proliferation. Most human and murine tumor subtypes shared some, but not all, features with a specific FACS-purified normal cell type; thus for most tumors a potential distinct cell type of ‘origin’ could be assigned. We found that both human luminal progenitor and mouse fetal mammary stem cell features predicted pCR sensitivity across all breast cancer patients even after controlling for intrinsic subtype, proliferation, and clinical variables. This work identifies new clinically relevant gene signatures and highlights the value of a developmental biology perspective for uncovering relationships between tumor subtypes and their potential normal cellular counterparts.Electronic supplementary materialThe online version of this article (doi:10.1007/s10549-014-3262-6) contains supplementary material, which is available to authorized users.
title: Pelvic pathology as a cause of hip & groin pain in women of childbearing age
Creators: name: Ruiz Morin, Berta
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Obstetrics
subject: Diagnostic procedure
subject: MR
subject: Pelvis
subject: Genital / Reproductive system female

description: Learning objectives Background Imaging findings OR Procedure Details Conclusion References Personal Information
description: Learning objectives: To bear in mind gynecologic causes as a source of groin / hip (pelvic) pain, which is a very common clinical problem. To illustrate the spectrum of pelvic pathologies that may appear as hip and/or groin...
Conditions for determining global binding folds from Self-locking degree-4 vertex origami structures.
Creators: name: Hongbin Fang
name: Suyi Li
name: K. W. Wang
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Mechanical Engineering
subject: FOS: Mechanical engineering
subject: 90506 Structural Engineering
subject: FOS: Civil engineering

description: This supplementary provides the detailed conditions for determining the global binding folds in the self-locking sheets and blocks.
Electron spin resonance spectroscopy of small ensemble paramagnetic spins using a single nitrogen-vacancy center in diamond
Creators: name: Abeywardana, Chathuranga
name: Stepanov, Viktor
name: Cho, Franklin H.
name: Takahashi, Susumu
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: A nitrogen-vacancy (NV) center in diamond is a promising sensor for nanoscale magnetic sensing. Here we report electron spin resonance (ESR) spectroscopy using a single NV center in diamond. First, using a 230 GHz ESR spectrometer, we performed ensemble ESR of a type-Ib sample crystal and identified a substitutional single nitrogen impurity as a major paramagnetic center in the sample crystal. Then, we carried out free-induction decay and spin echo measurements of the single NV center to study static and dynamic properties of nanoscale bath spins surrounding the NV center. We also measured ESR spectrum of the bath spins using double electron-electron resonance spectroscopy with the single NV center. The spectrum analysis of the NV-based ESR measurement identified that the detected spins are the nitrogen impurity spins. The experiment was also performed with several other single NV centers in the diamond sample and demonstrated that the properties of the bath spins are unique to the NV centers indicating the probe of spins in the microscopic volume using NV-based ESR. Finally, we discussed the number of spins detected by the NV-based ESR spectroscopy. By comparing the experimental result with simulation, we estimated the number of the detected spins to be $\leq$ 50 spins.
description: 15 pages and 5 figures
title: Acute knee trauma: 0,3 T vs 1,5 T
Creators: name: Sivakova, Elena
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Musculoskeletal soft tissue
subject: Musculoskeletal joint
subject: Extremities
subject: MR
subject: Equipment
subject: Acute
subject: Trauma
subject: Pathology

description: Learning objectives Background Imaging findings OR Procedure Details Conclusion References Personal Information
description: Learning objectives: To evaluate and get familiar with MR-imaging of acute knee trauma To reveal specific image patterns in acute knee trauma To compare the visualisation of the image changes using 0,3 T and 1,5 T...
Soft Expansion of Double-Real-Virtual Corrections to Higgs Production at N$^3$LO
Creators: name: Anastasiou, Charalampos
name: Duhr, Claude
name: Dulat, Falko
name: Furlan, Elisabetta
name: Herzog, Franz
name: Mistlberger, Bernhard
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present methods to compute higher orders in the threshold expansion for the one-loop production of a Higgs boson in association with two partons at hadron colliders. This process contributes to the N$^3$LO Higgs production cross section beyond the soft-virtual approximation. We use reverse unitarity to expand the phase-space integrals in the small kinematic parameters and to reduce the coefficients of the expansion to a small set of master integrals. We describe two methods for the calculation of the master integrals. The first was introduced for the calculation of the soft triple-real radiation relevant to N$^3$LO Higgs production. The second uses a particular factorization of the three body phase-space measure and the knowledge of the scaling properties of the integral itself. Our result is presented as a Laurent expansion in the dimensional regulator, although some of the master integrals are computed to all orders in this parameter.
description: 30 pages
Conditions for determining global binding folds from Self-locking degree-4 vertex origami structures
Creators: name: Hongbin Fang
name: Suyi Li
name: K. W. Wang
Publisher: name: The Royal Society
Year: 2016
Subjects: subject: Mechanical Engineering
subject: FOS: Mechanical engineering
subject: 90506 Structural Engineering
subject: FOS: Civil engineering

description: This supplementary provides the detailed conditions for determining the global binding folds in the self-locking sheets and blocks.
title: Use of slot-scanning radiographic system to depict vertebral fractures in primary hyperparathyroidism
Creators: name: Chougar, Lydia
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Outcomes
subject: Endocrine disorders
subject: Diagnostic procedure
subject: Computer Applications-Detection, diagnosis
subject: Plain radiographic studies
subject: Digital radiography
subject: Musculoskeletal spine
subject: Musculoskeletal bone

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: The risk of vertebral fracture is increased in patients with primary hyperparathyroidism. Two factors account for this risk: the decrease of bone mineral density and the alteration of bone microarchitecture. The detection of vertebral...
title: Cervical spine trauma: When best to call your orthopedic spine surgeon immediately. Understanding classification systems.
Creators: name: Kaniewska, Malwina
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Trauma
subject: Education and training
subject: Acute
subject: Surgery
subject: Structured reporting
subject: Education
subject: MR
subject: CT
subject: Musculoskeletal spine
subject: Musculoskeletal joint
subject: Musculoskeletal bone

description: Learning objectives Background Imaging findings OR Procedure Details Conclusion References Personal Information
description: Learning objectives: To familiarise musculoskeletal radiologists with cervical spine injury classification systems such as Allen and Fergusson, SLIC and AOSpine classification. To standardise terminology for cervical spine injuries in order to facilitate smooth and...
Large Eddy Simulation of the Pulsating, Non-Reacting Flow in Combustion Chambers
Creators: name: Pritz, Balazs
Publisher: name: Karlsruhe
Year: 2009
Subjects: LES
combustion
instabilities
damping
pulsating

description: In the present work a numerical investigation of the pulsating, non-reacting flow in a combustion chamber, and a coupled system of burner plenum and combustion chamber is presented. The results are compared with an analytical model and experimental data. The numerical simulations provide the damping ratio, an important input, for the analytical model, which was developed to predict the stability limits of technical combustion systems.
Relations Between Central Black Hole Mass and Total Galaxy Stellar Mass in the Local Universe
Creators: name: Reines, Amy E.
name: Volonteri, Marta
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Scaling relations between central black hole (BH) mass and host galaxy properties are of fundamental importance to studies of BH and galaxy evolution throughout cosmic time. Here we investigate the relationship between BH mass and host galaxy total stellar mass using a sample of 262 broad-line active galactic nuclei (AGN) in the nearby Universe (z < 0.055), as well as 79 galaxies with dynamical BH masses. The vast majority of our AGN sample is constructed using Sloan Digital Sky Survey spectroscopy and searching for Seyfert-like narrow-line ratios and broad H-alpha emission. BH masses are estimated using standard virial techniques. We also include a small number of dwarf galaxies with total stellar masses M_stellar < 10^9.5 Msun and a sub-sample of the reverberation-mapped AGNs. Total stellar masses of all 341 galaxies are calculated in the most consistent manner feasible using color-dependent mass-to-light ratios. We find a clear correlation between BH mass and total stellar mass for the AGN host galaxies, with M_BH proportional to M_stellar, similar to that of early-type galaxies with dynamically-detected BHs. However, the relation defined by the AGNs has a normalization that is lower by more than an order of magnitude, with a BH-to-total stellar mass fraction of M_BH/M_stellar ~ 0.025% across the stellar mass range 10^8 < M_stellar/Msun < 10^12. This result has significant implications for studies at high redshift and cosmological simulations in which stellar bulges cannot be resolved.
description: Accepted for publication in the Astrophysical Journal. 15 pages, 12 figures
歌唱者ダイアライゼーションに向けた 歌唱者識別手法の比較
Creators: name: 田中 麻衣
Publisher: name: Zenodo
Year: 2023
Subjects: 歌唱者認識
歌唱者ダイアライゼーション

description: 本稿では,グループ楽曲における歌唱者ダイアライゼーション実現に向け,複 数の歌唱者の識別を行う手法の精度比較を行う. 初めて聞くグループ歌唱楽曲に対して、誰がどこを歌っているかを聞き分ける ことは難しい.もしもそこで誰がどこを歌っているかの情報を見ながら楽曲を聴く ことができれば,はじめて楽曲を聴く場合でも,より楽曲を楽しむことができる. 「誰がどこを歌っているか」を自動で同定する処理は、歌唱者ダイアライゼー ションと呼ばれる.歌唱者識別に関連する研究は多く存在するが,1 つの楽曲内で の歌唱者の交代を前提とした歌唱者ダイアライゼーションを行っている研究事例 は少ない. 本稿では,背景音付きの音源から既存の音源分離モデルを用いてボーカルのみを 抽出し,1s や 2s ごとに分割した信号にする.この信号を用いて,いくつかの手法 で歌唱者識別を行い,その精度を比較する.識別手法ではクラスタリングや RNN, LSTM,CNN 等を利用した. 結果として 2s ごとに分割した信号を用いて,CNN で学習したモデルが一番良 い結果を残し,正解率の中央値が 0.7706 であった.
title: Knee Trauma: Compliance with the Ottawa Knee Rule.
Creators: name: Patel, Kunal
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Trauma
subject: Education
subject: Conventional radiography
subject: Musculoskeletal joint

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: Knee trauma is a common presentation to the Emergency Department and in the United Kingdom across the majority of the National Health Service. Demand for radiological examinations is rising which inveitably puts more pressure on the radiological...
Supporting cross-disciplinary research in natural sciences
Creators: name: Joly, Alexis
name: Giuffrida, Maria
name: Willems, Marieke
name: Justamante Rodríguez, Ángela
Publisher: name: Zenodo
Year: 2022
Subjects: AI,
plant
species
identification
API
biodiversity
mobile
citizenobservatory
EOSCinPractice

description: This story derives from a market need identified by the service provider. There are thousands of applications in the natural sciences field who were asking for an automated plant identification system within their own applications. The proposed solution is called Pl@ntNET, a citizen observatory and AI-based Platform designed to monitor plants biodiversity and help identify plants via pictures. It is organised in different thematic and geographical floras operational via a search engine. The solution is provided by a consortium of French research organisms piloted by Inria, the French national research institute for digital science and technology. The user community of Pl@ntNet consists of (1) the citizen and citizen scientists who are interested in identifying and knowing more about plants, and (2) developers of applications and software for plant identification, gardening, biodiversity management, agroecology or other related fields. The service is available on the EOSC Portal Catalogue and Marketplace and was developed within the Cos4Cloud Project. The full list of EOSC in practice stories is available here
title: Συγκριτική ανάλυση των δυνατοτήτων εκμετάλλευσης γεωλογικών σχηματισμών που εμπεριέχουν σπάνιες γαίες στον Ελλαδικό και Ευρωπαϊκό χώρο
Creators: name: Ριτης Αθανασιος
Publisher: name: Technical University of Crete
Year: 2023

description: Οι Σπάνιες Γαίες (ΣΓ)με την πρόοδο της τεχνολογίας, αποκτούν διαρκώς αυξανόμενο ρόλο και σήμερα η χρήση τους είναι καθοριστική για την κατασκευή σημαντικών εφαρμογών σε πολλά επίπεδα της ανθρώπινης ζωής και πολιτισμού. Το αναδυόμενο αυτό επιστημονικό πεδίο έχει πολυδύναμο ρόλο όχι μόνο στη παγκόσμια τεχνολογία, αλλά και στην οικονομική, κοινωνική και πολιτική αλληλεπίδραση μεταξύ των κρατών του πλανήτη.
Με βάση τα παραπάνω, σκοπός της παρούσας διπλωματικής εργασίας ήταν να εμπλουτιστεί η σχετικά φτωχή βιβλιογραφική ενημέρωση στην Ελληνική γλώσσα, και να αναδειχτούν παραδείγματα περιοχών, με δυνητική προοπτική στο πεδίο της εκμετάλλευσης, τόσο στην Ευρώπη όσο και στην Ελλάδα. Επίσης, να τονιστεί η ανάγκη επιτάχυνσης της τεχνολογικής προόδου στην κατεύθυνση της επίλυσης προβλημάτων εξόρυξης και μεταλλουργικής επεξεργασίας των σπανίων γαιών προς όφελος της ανθρώπινης προόδου και ευημερίας και να αναδειχθούν συγχρόνως οι παράμετροι του σεβασμού στο περιβάλλον και της παγκόσμιας συνεργασίας.
Για την επίτευξη των παραπάνω, μετά από τον βιβλιογραφικό ορισμό, την ταξινόμηση των ΣΓ, την παρουσίαση του γεωλογικού και ορυκτολογικού περιβάλλοντός των, αναφέρονται οι εφαρμογές τους στη σύγχρονη ζωή, αλλά και το περιβαλλοντολογικό - οικονομικό πλαίσιο και τα κριτήρια που διέπουν την εκμετάλλευσή τους. Αναφέρεται η κατανομή των ΣΓ σε παγκόσμιο, ευρωπαϊκό και πανελλαδικό επίπεδο. Γίνεται εμφανής ο παγκόσμιος ρόλος της Κίνας σε εξορυκτικό επίπεδο, ενώ η σχετική με τις ΣΓ τεχνολογία μεταλλουργίας που διαθέτει, την καθιστούν σημαντικό παγκόσμιο συνεργάτη στο συγκεκριμένο πεδίο. Τέλος σε δύο περιοχές στην Ευρώπη (Norra Kärr που βρίσκεται στη νοτιοκεντρική Σουηδία και το Kvanefjeld που βρίσκεται στην νότια Γροιλανδία) και σε δύο στην Ελλάδα ( Παρνασσό -Γκιώνα στη Στερεά Ελλάδα και στην περιοχή Nέας Περάμου και Στρυμονικού κόλπου στη ευρύτερη περιοχή Καβάλας), μελετάται και αναλύεται η πιθανότητα εξορυκτικού οφέλους.
Συμπερασματικά, παρά τον παγκόσμια πρωταγωνιστικό ρόλο των ΣΓ στην τεχνολογία, οικονομία και πολιτική, η εξορυκτική και μεταλλουργική διεργασία στις οποίες υπόκεινται είναι αρκετά πίσω ακόμη και εξαρτώνται όχι μόνο από την σχετική τεχνολογία και τεχνογνωσία, αλλά και από περιβαλλοντολογικούς κανόνες, καθώς και από κοινωνικές και πολιτικές συμπεριφορές. Στις αναλυθείσες περιοχές στην Ευρώπη η μελλοντική εξόρυξη και εκμετάλλευση των ΣΓ επιβραδύνεται από περιβαλλοντολογικούς και οικονομικούς περιορισμούς, ενώ στην Ελλάδα η επιπλέον πληρέστερη μελέτη της ορυκτολογίας και γεωλογίας των υποψηφίων περιοχών θα μπορούσε να αυξήσει την μελλοντική δυναμική τους στο πεδίο των ΣΓ.
Obesity, body fat distribution, and risk of breast cancer subtypes in African American women participating in the AMBER Consortium
Creators: name: Haiman, Christopher A.
name: Adams-Campbell, Lucile L.
name: Park, Song Yi
name: Olshan, Andrew F.
name: Rosenberg, Lynn
name: Troester, Melissa A.
name: Hong, Chi Chen
name: Bandera, Elisa V.
name: Bethea, Traci N.
name: Ambrosone, Christine B.
name: Chandran, Urmila
name: Palmer, Julie R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: African American (AA) women are more likely than white women to be obese and to be diagnosed with ER- and triple negative (TN) breast cancer, but few studies have evaluated the impact of obesity and body fat distribution on breast cancer subtypes in AA women. We evaluated these associations in the AMBER Consortium by pooling data from four large studies.
title: Lipoma Ultrasound - Introducing a New Pathway
Creators: name: Tang, Christopher
Publisher: name: European Society of Muscoskeletal Radiology
Year: 2017
Subjects: subject: Tissue characterisation
subject: Education and training
subject: Education
subject: Diagnostic procedure
subject: Ultrasound
subject: MR
subject: Soft tissues / Skin
subject: Musculoskeletal soft tissue

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: Lipomas are the most commonly encountered soft tissue lesions on general ultrasound lists.The main differential for a lipoma is a low-grade liposarcoma, which can be challenging to distinguish on ultrasound. Currently there is no national guidance...
Race, response to chemotherapy, and outcome within clinical breast cancer subtypes
Creators: name: Carey, L. A.
name: Deal, A. M.
name: Anders, C. K.
name: Reeder-Hayes, K.
name: Tichy, J. R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The effect of race on breast cancer outcome is confounded by tumor and treatment heterogeneity. We examined a cohort of women with stage II–III breast cancer treated uniformly with neoadjuvant chemotherapy to identify factors associated with racial differences in chemotherapeutic response and long-term survival. Using a prospective database, we identified women with stage II-III breast cancer treated with neoadjuvant chemotherapy from 1998 to 2011. Race was categorized as African-American (AA) or non-AA. Preplanned subtype analyses were stratified by hormone receptor (HR) and HER2. Pathologic response to chemotherapy (pCR), time to recurrence (TTR), and overall survival (OS) were assessed using logistic regression, Kaplan–Meier method, and Cox proportional hazards regression analyses. Of 349 women identified, 102 (29 %) were AA, who were younger (p = 0.03), more obese (p < 0.001), and less likely to have HR+/HER2–tumors (p = 0.01). No significant differences in pCR rate by race were found. At median follow-up of 6.5 years, AA had worse TTR (hazard ratio 1.51, 95 % CI 1.02–2.24), which was attenuated in multivariable modeling, and there was no significant difference in OS. When stratified by HR, worse outcomes were limited to HR+AA (TTR hazard ratio 1.85, 95 % CI 1.09–3.14; OS hazard ratio 2.42 95 % CI 1.37–4.28), which remained significant in multivariable analysis including pCR rate and BMI. With long-term follow-up, racial disparity in outcome was limited to HR+ breast cancer, with no apparent contribution of chemotherapy sensitivity. This suggests that disparity root causes may be driven by HR+ factors such as unmeasured molecular differences, endocrine therapy sensitivity, or adherence.