cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Invariant Chain Controls the Activity of Extracellular Cathepsin L
Creators: name: Fiebiger, Edda
name: Erickson, Ann
name: Villadangos, José
name: Bikoff, Elizabeth
name: Weber, Ekkehard
name: Ploegh, Hidde L.
name: Maehr, René
name: Lennon-Duménil, Ana Maria
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Secretion of proteases is critical for degradation of the extracellular matrix during an inflammatory response. Cathepsin (Cat) S and L are the major elastinolytic cysteine proteases in mouse macrophages. A 65 amino acid segment of the p41 splice variant (p4165aa) of major histocompatibility complex class II–associated invariant chain (Ii) binds to the active site of CatL and permits the maintenance of a pool of mature enzyme in endosomal compartments of macro-phages and dendritic cells (DCs). Here we show that interaction of p4165aa with mature CatL allows extracellular accumulation of the active enzyme. We detected mature CatL as a complex with p4165aa in culture supernatants from antigen-presenting cells (APCs). Extracellular accumulation of mature CatL is up-regulated by inflammatory stimuli as observed in interferon (IFN)-γ–treated macrophages and lipopolysaccharide (LPS)-activated DCs. Despite the neutral pH of the extracellular milieu, released CatL associated with p4165aa is catalytically active as demonstrated by active site labeling and elastin degradation assays. We propose that p4165aa stabilizes CatL in the extracellular environment and induces a local increase in the concentration of matrix-degrading enzymes during inflammation. Through its interaction with CatL, Ii may therefore control the migratory response of APCs and/or the recruitment of effectors of the inflammatory response.
Die Zusammenarbeit von pädagogischen Fachkräften und Eltern im Feld der frühkindlichen Bildung, Betreuung und Erziehung
Creators: name: Fröhlich-Gildhoff, Klaus
Publisher: name: bildungsforschung
Year: 2013

description: Im Mittelpunkt dieses Beitrags stehen, nach einer grundlegenden Betrachtung der Bedeutung der Zusammenarbeit zwischen Fachkräften in Kitas und den Eltern/Familien, die Ergebnisse der wenigen verfügbaren empirischen Studien zu diesem Thema. Daraus wird einerseits deutlich, dass verschiedene Formen der Kooperation relativ breit praktiziert werden – deren Wirkung jedoch stark abhängig ist von den â€šdahinterâ€˜ stehenden handlungsleitenden Orientierungen der PädagogInnen. Aus den Studien werden Standards fuÌˆr die Zusammenarbeit von Bildungsinstitutionen mit Eltern/Familien abgeleitet und Bezüge zur nötigen Qualifikation der Fachkräfte hergestellt
description: bildungsforschung, Bd. 1 (2013): Nicht-pädagogisches Personal in Bildungseinrichtungen
Polymineralic hydrothermal veins in the Paleozoic Jandaq ophiolite gabbros (Central Iran); Evidence for ingression of high temperature seawater-derived fluids in to the gabbroic section of the Paleo-Tethys oceanic crust
Creators: name: Nosouhian, Nargess
name: Torabi, Ghodrat
name: Morishita, Tomoaki
name: Arai, Shoji
Publisher: name: Periodico di Mineralogia
Year: 2022

description: The Paleozoic Jandaq ophiolite is situated in the western part of the Central-East Iranian microcontinent and belongs to the Paleo-Tethys Ocean. This ophiolite consist of mantle peridotite and serpentinized mantle peridotite, metagabbro, basic and ultrabasic metamorphosed dikes, metapyroxenite, amphibolite, rodingite, and listwaenite which are covered by Late Paleozoic schist and marble. The joints and cracks of the Jandaq gabbroic intrusions are filled by hydrothermal minerals. Rock-forming minerals of the hydrothermal veins are calcite, prehnite, garnet (grossular-andradite), epidote, clinopyroxene (diopside), chlorite, albite and sericite. Calcite and garnet are the last-formed minerals in these veins and calcite with coarse-grain morphology is the major mineral. The main textures are granoblastic and poikiloblastic. Very low abundances of Al, Ti, Na, Cr and rare earth elements (REEs) in clinopyroxenes support their metamorphic origin. The high abundance of calcite in the investigated veins, the presence of clinopyroxene, garnet, prehnite and epidote as Ca-rich minerals, associated with the positive Eu anomaly in the chondrite-normalized REE patterns of minerals support that the penetrating hydrothermal fluid were enriched in CO2 and leached the lower crust gabbros before crystallization. Accordingly, the hydrothermal veins in the Jandaq ophiolite are interpreted as remind of high temperature circulation of seawater and carbonated fluids.
description: Periodico di Mineralogia, Vol. 91 No. 2 (2022)
Changes in deep-sea asteroid fauna along the northern Mid-Atlantic Ridge
Creators: name: DILMAN, Anna B.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2013

description: Data on species distribution pattern and biogeographic structure of the deep–sea asteroid fauna (>1000 m) from the northern Mid-Atlantic Ridge (MAR) are presented. Samples were obtained from five areas between the Azores and the middle part of the Reykjanes Ridge (42°-60°N), on a series of Russian cruises as well as in two large-scale multi- disciplinary projects: MAR-ECO and ECOMAR. A total of 61 species were identified. Species similarity analysis between five study areas along the northern MAR revealed differences between areas south and north of the Charlie-Gibbs Fracture Zone (CGFZ). This region is also characterized by changes in the biogeographic structure of the asteroid fauna. Pronounced changes in species composition point at fauna turnover in the CGFZ area.
Effects of Pharmaceutical Care and Nutrition Counseling for Diabetic Patients in the Diabetic Clinic at Srisomdej Hospital,Roi-et Province
Creators: name: Jitraporn Maneeruang
Publisher: name: Faculty of Pharmaceutical Sciences KKU MSU UBU
Year: 2010
Subjects: Pharmaceutical care, Diabetic outpatient, Nutrition counseling based on food pyramid, Drug-related problems and Knowledge

description: Isan Journal ofPharmaceutical Sciences, 6, 1, 52-65
Down-regulation of CD46 by Piliated Neisseria gonorrhoeae
Creators: name: Atkinson, John P.
name: Cannon, Janne G.
name: Koomey, Michael
name: Gill, Darcy B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Human membrane cofactor protein (CD46) protects host cells against complement attack and may function as a receptor for pathogenic Neisseriae. We assessed CD46 expression in the human cervical cell line ME-180 after exposure to Neisseria gonorrhoeae. Piliated but not nonpiliated gonococci adhered to cells and produced up to an 80% reduction in CD46 surface expression by 6 h that persisted for at least 24 h. This response required a minimum multiplicity of infection of 10 and was not prevented by antibodies to CD46. CD46 down-regulation was not attributable to intracellular retention or a global or specific shutdown of mRNA or protein synthesis. Substantial quantities of CD46 were found in the supernatants, indicating a specific shedding of this protein. Adherent gonococci lacking the pilus retraction protein PilT did not down-regulate CD46 but de-repression of pilT expression restored CD46 down-regulation. After experimental infection of human volunteers with a gonococcal variant incapable of inducing CD46 down-regulation, variants of this strain were reisolated that exhibited CD46 down-regulation. Pilus-mediated interactions of gonococci with human epithelial cells results in a pathogen-induced manipulation of the host cell environment in which a membrane protein is removed from epithelial cells by liberation into the surrounding milieu.
Bright 30 THz Impulsive Solar Bursts
Creators: name: Kaufmann, P.
name: White, S. M.
name: Marcon, R.
name: Kudaka, A. S.
name: Cabezas, D. P.
name: Cassiano, M. M.
name: Francile, C.
name: Fernandes, L. O. T.
name: Ramirez, R. F. Hidalgo
name: Luoni, M.
name: Marun, A.
name: Pereyra, P.
name: de Souza, R. V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Impulsive 30 THz continuum bursts have been recently observed in solar flares, utilizing small telescopes with a unique and relatively simple optical setup concept. The most intense burst was observed together with a GOES X2 class event on October 27, 2014, also detected at two sub-THz frequencies, RHESSI X-rays and SDO/HMI and EUV. It exhibits strikingly good correlation in time and in space with white light flare emission. It is likely that this association may prove to be very common. All three 30 THz events recently observed exhibited intense fluxes in the range of 104 solar flux units, considerably larger than those measured for the same events at microwave and sub-mm wavelengths. The 30 THz burst emission might be part of the same spectral burst component found at sub-THz frequencies. The 30 THz solar bursts open a promising new window for the study of flares at their origin
description: 11 pages, 4 Figures J. Geophys. Res - Space Physics, accepted, May 21, 2015
(2656) John Clark
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
SEBASTIAN FRANCK. On the Horrible Vice of Drunkenness, etc. A Document of the Reformation Period on Inebriety.
Creators: name: Jellinek, E. M. (Elvin Morton)
Publisher: name: No Publisher Supplied
Year: 1941

description: An article published in the Quarterly Journal of Studies on Alcohol and in the volume entitled Classics of the Alcohol Literature, the primary source of many seminal articles related to Alcohol Studies.
Schulfähigkeit des Kindes und Befähigung der Eltern. Empirische und normative Fragen an die „Einschulung“ der Familie
Creators: name: Andresen, Sabine
name: Seddig, Nadine
name: Künstler, Sophie
Publisher: name: bildungsforschung
Year: 2013

description: Im Kontext des zunehmenden öffentlichen, wie wissenschaftlichen Interesses an der Gestaltung des Übergangs von der Kindertagesstätte in die Grundschule, beschäftigt sich der vorliegende Artikel mit den verschiedenen Adressierungen und Verantwortlichkeitszuschreibungen in Bezug auf die Einschulung. Dabei wird die These verfolgt, dass die zunehmende Aufmerksamkeit nicht allein die Schulfähigkeit des Kindes betrifft, sondern dass durch die wachsenden Bemühungen um eine gelingende Übergangsgestaltung vielmehr die ganze Familie „eingeschult“ wird und MuÌˆtter und VaÌˆter dies auch als Frage von Fähigkeiten und Befähigung ihrer selbst erfahren. Nachdem zunächst der internationale Forschungsstand zum Thema skizziert wird, liegt das Hauptaugenmerk des Artikels deswegen im Anschluss auf der Darstellung der im Rahmen des qualitativen Projektes „Schulfähigkeit und Befähigung“ rekonstruierten Schlüsselthemen von Eltern, die mit ihren Kindern den Übergang und dessen Gestaltung miterlebt haben.
description: bildungsforschung, Bd. 1 (2013): Nicht-pädagogisches Personal in Bildungseinrichtungen
Die Einbindung pädagogischer Laien in den Alltag von Ganztagsschulen
Creators: name: Steiner, Christine
Publisher: name: bildungsforschung
Year: 2013

description: Ganztagsschulen arbeiten mit einem erweiterten Kreis an Mitarbeitenden zusammen, einschließlich Personen, die gemeinhin als pädagogische Laien gelten. Von Ganztagsschulen wird jedoch auch erwartet, dass sie die pädagogische Qualität verlässlich gewähren und die Zusammenarbeit sehr unterschiedlicher Mitarbeiter gekonnt managen. In diesem Spannungsfeld ist die Rolle pädagogischer Laien unklar. Mit dem Beitrag wird daher der Versuch unternommen, sie näher zu bestimmen.
description: bildungsforschung, Bd. 1 (2013): Nicht-pädagogisches Personal in Bildungseinrichtungen
Autonomous surveillance for biosecurity
Creators: name: Jurdak, Raja
name: Elfes, Alberto
name: Kusy, Branislav
name: Tews, Ashley
name: Hu, Wen
name: Hernandez, Emili
name: Kottege, Navinda
name: Sikka, Pavan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Robotics (cs.RO)
subject: Computers and Society (cs.CY)
subject: FOS: Computer and information sciences

description: The global movement of people and goods has increased the risk of biosecurity threats and their potential to incur large economic, social, and environmental costs. Conventional manual biosecurity surveillance methods are limited by their scalability in space and time. This article focuses on autonomous surveillance systems, comprising sensor networks, robots, and intelligent algorithms, and their applicability to biosecurity threats. We discuss the spatial and temporal attributes of autonomous surveillance technologies and map them to three broad categories of biosecurity threat: (i) vector-borne diseases; (ii) plant pests; and (iii) aquatic pests. Our discussion reveals a broad range of opportunities to serve biosecurity needs through autonomous surveillance.
description: 26 pages, Trends in Biotechnology, 3 March 2015, ISSN 0167-7799, http://dx.doi.org/10.1016/j.tibtech.2015.01.003. (http://www.sciencedirect.com/science/article/pii/S0167779915000190)
Hilflose häkelnde Helfer? Zur pädagogischen Rationalität von Integrationshelfer/inne/n im inklusiven Unterricht
Creators: name: Heinrich, Martin
name: Lübeck, Anika
Publisher: name: bildungsforschung
Year: 2013

description: Alle Kinder mit sonderpädagogischem Förderbedarf haben gemäß UN-Behindertenrechtskonvention Rechtsanspruch auf Beschulung in einer allgemeinen Schule. Angesichts massiven Mangels an sonderpädagogisch qualifiziertem Personal ist zu vermuten, dass demnächst eine Vielzahl von Integrationshelfer/inne/n eingestellt wird. Empirische Studien zu deren Arbeitsbedingungen, Qualifikationen und praktischen Herausforderungen liegen bislang kaum vor. Ausgehend von einer objektiv-hermeneutischen Einzelfallrekonstruktion werden deren strukturelle Handlungsmöglichkeiten im inklusiven Unterricht angesichts objektiv prekärer Arbeitsbedingungen beleuchtet.
description: bildungsforschung, Bd. 1 (2013): Nicht-pädagogisches Personal in Bildungseinrichtungen
O EFEITO MODERADOR DA CONCENTRAÇÃO DE MERCADO NA RELAÇÃO ENTRE SLACK FINANCEIRO E DESEMPENHO
Creators: name: Teixeira, Nayna Nali
name: Macedo, Marcelo Alvaro Da Silva
Publisher: name: Revista de Informação Contábil
Year: 2023
Subjects: Concentração; Slack financeiro; Efeito moderador; Desempenho

description: Esta pesquisa tem como propósito analisar o efeito moderador da concentração de mercado na relação entre slack financeiro e desempenho. A estrutura do mercado determina a conduta ou o comportamento das firmas, que juntas, determinam o seu desempenho em um determinado mercado. Assim, estudos sobre a relação slack e desempenho deveriam considerar o efeito moderador da estrutura de mercado (concentração) na relação entre a conduta das empresas (slack financeiro) e o desempenho. Foram extraídos dados anuais de 74 empresas listadas na B3 entre 2010-2019, com 740 observações de seis setores de atuação. Foram realizadas seis regressões múltiplas com dados em painel para efeitos fixos, aplicando-se controles individuais e temporais. Confirmando as hipóteses, os resultados revelam que quanto menor a concentração de mercado, maior o impacto positivo do slack disponível no desempenho e quanto maior a concentração, menor o impacto negativo dos slacks recuperável e potencial no desempenho.
description: Revista de Informação Contábil, v. 16 (2022): Publicação contínua
The Effect of the Interventions on Basic Knowledge of and Skills of Health Care Workers in the Preparation of Cytotoxic Drugs at Sappasithiprasong Hospital, Ubon Ratchathani Province
Creators: name: Anun Chaikoolvatana
Publisher: name: Faculty of Pharmaceutical Sciences KKU MSU UBU
Year: 2010
Subjects: Cytotoxic drugs preparation, Interventions, Aseptic hand-washing, Vertical laminar air flow

description: Isan Journal ofPharmaceutical Sciences, 6, 1, 66-76
Influence of streams discharges on the structure of fish communities of Portuguese land-locked coastal lagoons
Creators: name: FÉLIX, Pedro M.
name: CORREIA, Maria João
name: CHAINHO, Paula
name: COSTA, Maria José
name: CABRAL, Henrique N.
name: DOMINGOS, Isabel
name: COSTA, José Lino
name: CANCELA DA FONSECA, Luís
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2013

description: Land-locked coastal lagoons are naturally stressed environments that consequently constrain biological communities that colonize these systems, through direct or indirect influence. This study investigated the influence of groundwater outflows and catchment runoff on the fish community of Melides and Santo André, two land-locked coastal lagoons in southwest Portugal. Sampling of the fish communities was conducted during the closed period of the lagoons, using fyke net arrays placed at growing distances from the interface of freshwater discharges to the lagoonal areas not directly influenced by freshwater discharges, with the concomitant analysis of nutrients and several environmental parameters. The fish communities of these lagoons are mainly dominated by marine juvenile migrants and tolerant species, the latter including diadromous migrants and resident species. The structure of fish communities only showed longitudinal spatial differences, between upstream and downstream areas. However, the distribution of benthic species, like the European eel and Senegalese sole, appears to be related to freshwater inputs. While S. senegalensis is more abundant in the freshwater discharge areas, A. anguilla follows the opposite trend.
(1880) Christine White
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The Role of Brg1 , a Catalytic Subunit of Mammalian Chromatin-remodeling Complexes, in T Cell Development
Creators: name: Su, Lishan
name: Bultman, Scott
name: Gebuhr, Thomas C.
name: Magnuson, Terry
name: Godfrey, Virginia
name: Kovalev, Grigoriy I.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Mammalian SWI–SNF-related complexes use brahma-related gene 1 (Brg1) as a catalytic subunit to remodel nucleosomes and regulate transcription. Recent biochemical data has linked Brg1 function to genes important for T lymphocyte differentiation. To investigate the role of SWI–SNF-related complexes in this lineage, we ablated Brg1 function in T lymphocytes. T cell–specific Brg1-deficient mice showed profound thymic abnormalities, CD4 derepression at the double negative (DN; CD4− CD8−) stage, and a developmental block at the DN to double positive (CD4+ CD8+) transition. 5′-bromo-2′-deoxyuridine incorporation and annexin V staining establish a role for Brg1 complexes in the regulation of thymocyte cell proliferation and survival. This Brg1-dependent cell survival is specific for developing thymocytes as indicated by the presence of Brg1-deficient mature T lymphocytes that have escaped the developmental block in the thymus. However, reductions in peripheral T cell populations lead to immunodeficiency and compromised health of mutant mice. These results highlight the importance of chromatin-remodeling complexes at different stages in the development of a mammalian cell lineage.
A multidisciplinary analysis of sea-urchin temporary adhesion: morphology, biomechanics and proteomics  A review
Creators: name: SANTOS, Romana
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2013

description: Sea urchins are exclusively benthic animals and, thus, their activities and adaptations are correlated with an existence on the ocean bottom. To withstand hydrodynamic forces, sea urchins rely on their adoral tube feet, specialized in locomotion and anchoring. Tube feet consist of a disc, which makes contact with the substratum, and a stem, which connects the disc to the test. Therefore, the tenacity with which an individual can anchor to a surface is determined by the strength of its numerous tube feet which, in turn, depends on the tensile strength of the stem and the adhesive power of the disc. The later is determined by the chemical properties of an adhesive secretion that is able to functionally assemble under- water and displace water, ions, and weakly bound polyions, properties that are rarely achieved by synthetic adhesives. In addition, sea urchins also possess an effective de-adhesive secretion that rapidly releases the tube foot in order to begin a new attachment-detachment cycle. Therefore, understanding the characteristics of this protein/carbohydrate-based adhesive is imperative to decipher sea urchin temporary adhesion and also, to accelerate the development of new biomimetic wet adhesives and antifouling agents. More than 10 years of research combining morphological, biomechanical and proteomics techniques have demonstrated that tube feet are unique mechano-sensory adhesive organs and highlighted putative adhesive proteins, thus constituting a step forward in the quest to decipher sea urchins temporary adhesion.
Biodiversity of echinoderms on underwater lava flows with different ages, from the Piton de La Fournaise (Reunion Island, Indian Ocean)
Creators: name: BOLLARD, Stéphanie
name: PINAULT, Mathieu
name: QUOD, Jean-Pascal
name: BOISSIN, Emilie
name: HEMERY, Lénaig
name: CONAND, Chantal
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2013

description: Echinoderms from Reunion Island have been studied mostly from west coast reefs. A recent faunal inventory (BIOLAVE) was conducted on the underwater lava flows of Piton de La Fournaise and constitutes the first submarine survey on the south-east side of the island. The aim of the present study was to evaluate the species richness in the different echinoderm classes and assess their potential as indicator of the colonisation of lava with different ages. During 8 days, 9 sites with different habitats defined by depth and substrate homogeneity were explored using a stratified sampling. Description of echinoderms and comparison of the taxonomic composition between sites of different ages and depths were presented. 45 species of the 5 classes were identified, belonging to 23 families and 32 genera. Ophiuroid was the most diverse class (22 species), followed by echinoids (13 species), asteroids and holothuroids (6 species each), and crinoids (2 species). Species number increased with lava flow's age, except for echinoids, which showed a higher species number on recent sites, but ophiuroids only showed a significantly higher species number on the oldest sites. On the contrary, species number tended to decrease with depth, but echinoids only showed a significantly higher species number on shallow water. Some asteroid, echinoid and holothuroid species, such as Aquilonastra richmondi, Asthenosoma varium, Echinothrix spp., Echinometra mathaei and Euapta godeffroyi, were observed on the most recent sites only, while some ophiuroid species were observed in deeper sites only. These characteristic species could be seen as bioindicators of disturbed environment or have a distribution restricted to deeper areas.
Additional file 2 of Rescue of common and rare exon 2 skipping variants of the GAA gene using modified U1 snRNA
Creators: name: Peruzzo, Paolo
name: Bergamin, Natascha
name: Bon, Martina
name: Cappelli, Sara
name: Longo, Alessandra
name: Goina, Elisa
name: Stuani, Cristiana
name: Buratti, Emanuele
name: Dardis, Andrea
Publisher: name: figshare
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Biological Sciences not elsewhere classified

description: Additional file 2.
The Role of Intramolecular Epitope Spreading in the Pathogenesis of Endemic Pemphigus Foliaceus (Fogo Selvagem)
Creators: name: Hans-Filho, Gunter
name: Diaz, Luis A.
name: Aoki, Valeria
name: Li, Ning
name: Rivitti, Evandro A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: We report here a relationship between intramolecular epitope spreading and the clinical onset of the endemic form of pemphigus foliaceus in a Brazilian community with a high prevalence and incidence of the disease. Also known as Fogo Selvagem (FS), this disease is characterized by severe skin blistering and pathogenic anti–desmoglein-1 (Dsg1) autoantibodies. These autoantibodies bind the Dsg1 ectodomain and trigger keratinocyte cell detachment, the hallmark of FS. We show that (a) sera from FS patients in the preclinical stage recognized epitopes on the COOH-terminal EC5 domain of Dsg1, (b) disease onset was associated with the emergence of antibodies specific for epitopes on the NH2-terminal EC1 and EC2 domains, (c) all sera from FS patients with active disease recognized the EC1 and/or EC2 domains, and (d) sera from FS patients in remission showed reactivity restricted to EC5. These results suggest that anti-Dsg1 autoantibodies in FS are initially raised against the COOH-terminal EC5 domain of Dsg1 in individuals without skin disease; in genetically predisposed subjects the autoimmune response may then undergo intramolecular epitope spreading toward epitopes on the NH2-terminal EC1 and EC2 domains of Dsg1 leading to disease onset. Moreover, intramolecular epitope spreading may also modulate remissions and relapses of FS.
CD4 − CD8 − T cells control intracellular bacterial infections both in vitro and in vivo
Creators: name: Cowley, Siobhán C.
name: Su, Jie
name: Hamilton, Elizabeth
name: Forman, James
name: Elkins, Karen L.
name: Frelinger, Jeffrey A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Memory T cells, including the well-known CD4+ and CD8+ T cells, are central components of the acquired immune system and are the basis for successful vaccination. After infection, CD4+ and CD8+ T cells expand into effector cells, and then differentiate into long-lived memory cells. We show that a rare population of CD4−CD8−CD3+αβ+γδ−NK1.1− T cells has similar functions. These cells potently and specifically inhibit the growth of the intracellular bacteria Mycobacterium tuberculosis (M. tb.) or Francisella tularensis Live Vaccine Strain (LVS) in macrophages in vitro, promote survival of mice infected with these organisms in vivo, and adoptively transfer immunity to F. tularensis LVS. Furthermore, these cells expand in the spleens of mice infected with M. tb. or F. tularensis LVS, and then acquire a memory cell phenotype. Thus, CD4−CD8− T cells have a role in the control of intracellular infection and may contribute to successful vaccination.
Cellular and molecular bases of biomineralization in sea urchin embryos
Creators: name: MATRANGA, Valeria
name: PINSINO, Annalisa
name: BONAVENTURA, Rosa
name: COSTA, Caterina
name: KARAKOSTIS, Konstantinos
name: MARTINO, Chiara
name: RUSSO, Roberta
name: ZITO, Francesca
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2013

description: Sea urchin embryos construct their skeleton following a precise gene-regulated time- and space-dependent programme, in concert with factors promoting cell adhesion and differentiation. The biomineral is deposited in a privileged extracellular space produced by the fused filopodia processes of the primary mesenchyme cells, the only cells producing a set of necessary matrix proteins. More than ten years ago we showed for the first time that signals from ectoderm cells promoted the expression of one of the major skeleton matrix genes by the primary mesenchyme cells. Since then, many of the crucial steps of this complex activation cascade, from ectoderm cells to embryonic spicules, have been elucidated. The experimental production of skeleton malformations, induced by the exposure to toxic metals or ionizing radiations, served as model to dissect the molecular mechanisms leading to biomineralization. With the aim of understanding the sea urchin skeleton physiology, we analysed the expression of well-known and newly-identified biomineral-related genes, including those coding for growth and transcription factors as well as for skeleton matrix proteins. This review summarizes our recent findings on sea urchin embryo skeletogenesis, with a particular attention to the role played by cellular and molecular signaling, approached by the use of experimentally induced skeleton malformations.
Single cell analysis shows decreasing FoxP3 and TGFβ1 coexpressing CD4 + CD25 + regulatory T cells during autoimmune diabetes
Creators: name: Wong, Carmen P.
name: Clarke, Stephen H.
name: Culton, Donna A.
name: Pop, Shannon M.
name: Tisch, Roland
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Natural CD4+CD25+ regulatory T (CD4+CD25+ T reg) cells play a key role in the immunoregulation of autoimmunity. However, little is known about the interactions between CD4+CD25+ T reg cells and autoreactive T cells. This is due, in part, to the difficulty of using cell surface markers to identify CD4+CD25+ T reg cells accurately. Using a novel real-time PCR assay, mRNA copy number of FoxP3, TGFβ1, and interleukin (IL)-10 was measured in single cells to characterize and quantify CD4+CD25+ T reg cells in the nonobese diabetic (NOD) mouse, a murine model for type 1 diabetes (T1D). The suppressor function of CD4+CD25+CD62Lhi T cells, mediated by TGFβ, declined in an age-dependent manner. This loss of function coincided with a temporal decrease in the percentage of FoxP3 and TGFβ1 coexpressing T cells within pancreatic lymph node and islet infiltrating CD4+CD25+CD62Lhi T cells, and was detected in female NOD mice but not in NOD male mice, or NOR or C57BL/6 female mice. These results demonstrate that the majority of FoxP3-positive CD4+CD25+ T reg cells in NOD mice express TGFβ1 but not IL-10, and that a defect in the maintenance and/or expansion of this pool of immunoregulatory effectors is associated with the progression of T1D.
Genese von Heterogenität im Fachunterricht – Ein Beitrag zur Kontextualisierung von Differenzierungspraktiken
Creators: name: Wischmann, Anke
name: Dietrich, Cornelie
Publisher: name: bildungsforschung
Year: 2014

description: Heterogenität stellt keine ontologisch gegebene Vielfalt dar. Vielmehr wird sie permanent in alltäglichen Praktiken hergestellt, stabilisiert und transformiert, so auch in Schule und Unterricht. Anhand zweier ethnografischer Fallstudien aus dem Deutsch- und Religionsunterricht einer dritten Grundschulklasse werden neben sozialen Differenzierungskategorien, auch fachspezifische Unterscheidungspraktiken untersucht und mithilfe der Dokumentarischen Methode ausgewertet.
description: bildungsforschung, Bd. 1 (2014): Lernen und Entwicklung in der zweiten Lebenshälfte: Perspektiven und epistemologische Zugänge in Deutschland und Frankre
ÉTUDE DU DÉVELOPPEMENT LARVAIRE DE DEUX SIPHONOPHORES : LENSIA CONOIDEA (CALYCOPHORE) ET FORSKALIA EDWARSI (PHYSONECTE)
Creators: name: CARRÉ, Danièle
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1967

description: Larvae of the Siphonophore Calycophore Lensia conoidea and of the Siphonophore Physonecte, Forskalia edwardsi were hatched and reared in the laboratory. Larval development in both species was observed in living specimens, and by studying histological sections.
Development is similar in both organisms until the planula stage. During the latter, different larval buds appear on the ventral surface.
In Lensia conoidea, a typical calyconula is finally produced by differentiation of a caducous larval swimming bell, while in Forskalia edwardsi, a pneumatophore and larval bracts are formed.
The swimming bell in Lensia conoidea and the pneumatophore in Forskalia edwardsi appear in the same antero-ventral region of the planula but their modes of formation differ. The swimming bell develops from a medusal nodule; the pneumatophore originates in a precocious invagination of some of ectodermal cells.
Current interpretations of the genesis and structure of larval organs in Siphonophores, and of homologies among these organs, are discussed in the light of this study.
Statistically-estimated tree composition for the northeastern United States at the time of Euro-American settlement
Creators: name: Paciorek, Christopher J.
name: Goring, Simon J.
name: Thurman, Andrew L.
name: Cogbill, Charles V.
name: Williams, John W.
name: Mladenoff, David J.
name: Peters, Jody A.
name: Zhu, Jun
name: McLachlan, Jason S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: We present a gridded 8 km-resolution data product of the estimated composition of tree taxa at the time of Euro-American settlement of the northeastern United States and the statistical methodology used to produce the product from trees recorded by land surveyors. Composition is defined as the proportion of stems larger than approximately 20 cm diameter at breast height for 22 tree taxa, generally at the genus level. The data come from settlement-era public survey records that are transcribed and then aggregated spatially, giving count data. The domain is divided into two regions, eastern (Maine to Ohio) and midwestern (Indiana to Minnesota). Public Land Survey point data in the midwestern region (ca. 0.8-km resolution) are aggregated to a regular 8 km grid, while data in the eastern region, from Town Proprietor Surveys, are aggregated at the township level in irregularly-shaped local administrative units. The product is based on a Bayesian statistical model fit to the count data that estimates composition on a regular 8 km grid across the entire domain. The statistical model is designed to handle data from both the regular grid and the irregularly-shaped townships and allows us to estimate composition at locations with no data and to smooth over noise caused by limited counts in locations with data. The model also allows us to quantify uncertainty in our composition estimates, making the product suitable for applications employing data assimilation. We expect this data product to be useful for understanding the state of vegetation in the northeastern United States prior to large-scale Euro-American settlement. In addition to specific regional questions, the data product can also serve as a baseline against which to investigate how forests and ecosystems change after intensive settlement. The data product is available at the NIS data portal as version 1.0.
description: 23 pages, 5 tables, 3 figures
Blood Glucose Level and Hematological Values in Diabetic Rats Received Leaf Extract from Clerodendrum disparifolium Blume.
Creators: name: Chusri Talubmook
Publisher: name: Faculty of Pharmaceutical Sciences KKU MSU UBU
Year: 2010
Subjects: Clerodendrum disparifolium Blume., Diabetic rats, Blood glucose level, Hematological values

description: Isan Journal ofPharmaceutical Sciences, 6, 1, 77-84
Prädiktoren der LehrerInnenverantwortung [Einzelbeitrag]
Creators: name: Turmo, Are
name: Christophersen, Knut-Andreas
name: Elstad, Eyvind
name: Geppert, Corinna
Publisher: name: bildungsforschung
Year: 2015

description: Der vorliegende Beitrag beschäftigt sich mit der Frage ob Lenks Modell zur Erfassung von grundsätzlichen Determinanten der LehrerInnenverantwortung, das durch Lauermann und Karabenick übernommen wurde, empirisch gestützt werden kann. Ziel dieses Beitrags ist es, kausale Beziehungen innerhalb dieses Modells mit Hilfe eines Strukturgleichungsmodells zu bewerten. Basierend auf Daten einer norwegischen LehrerInnenuntersuchung ergaben sich deutliche Zusammenhänge zwischen den Elementen des Modells. Relationales Vertrauen, informelles Lernen zwischen den Lehrerinnen und wahrgenommene Unterstützung durch SchulleiterInnen haben sich als wichtige Determinanten für die LehrerInnenverantwortung erwiesen, wenngleich die kontextuellen Faktoren in ihrer Eigenart komplexer zu sein scheinen. Es bedarf weiterer Forschung, um diese zu verstehen. Angesichts der Ergebnisse ist zu empfehlen, dass Schulbehörden einen Schwerpunkt auf die Gestaltung einer Politik legen, die die Vertrauensbeziehungen zwischen den LehrerInnen berücksichtigt.
description: bildungsforschung, Bd. 1 (2015): Visuelle Bildungsmedien
Cosmological Measurements with General Relativistic Galaxy Correlations
Creators: name: Raccanelli, Alvise
name: Montanari, Francesco
name: Bertacca, Daniele
name: Doré, Olivier
name: Durrer, Ruth
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We investigate the cosmological dependence and the constraining power of large-scale galaxy correlations, including all redshift-distortions, wide-angle, lensing and gravitational potential effects on linear scales. We analyze the cosmological information present in the lensing convergence and in the gravitational potential terms describing the so-called "relativistic effects," and we find that, while smaller than the information contained in intrinsic galaxy clustering, it is not negligible. We investigate how neglecting them does bias cosmological measurements performed by future spectroscopic and photometric large-scale surveys such as SKA and Euclid. We perform a Fisher analysis using the CLASS code, modified to include scale-dependent galaxy bias and redshift-dependent magnification and evolution bias. Our results show that neglecting relativistic terms introduces an error in the forecasted precision in measuring cosmological parameters of the order of a few tens of percent, in particular when measuring the matter content of the Universe and primordial non-Gaussianity parameters. Therefore, we argue that radial correlations and integrated relativistic terms need to be taken into account when forecasting the constraining power of future large-scale number counts of galaxy surveys.
description: 18 pages, 10 figures
The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis
Creators: name: Wen, Jing
name: Su, Lishan
name: Chang, Xing
name: Zheng, Pan
name: Seifers, Nick
name: Gao, Jian Xin
name: Jiang, Qi
name: Godfrey, Virginia L.
name: Liu, Yang
name: Zuo, Tao
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: The Scurfy mutation of the FoxP3 gene (FoxP3sf) in the mouse and analogous mutations in human result in lethal autoimmunity. The mutation of FoxP3 in the hematopoietic cells impairs the development of regulatory T cells. In addition, development of the Scurfy disease also may require mutation of the gene in nonhematopoietic cells. The T cell–extrinsic function of FoxP3 has not been characterized. Here we show that the FoxP3sf mutation leads to defective thymopoiesis, which is caused by inactivation of FoxP3 in the thymic stromal cells. FoxP3 mutation also results in overexpression of ErbB2 in the thymic stroma, which may be involved in defective thymopoiesis. Our data reveal a novel T cell–extrinsic function of FoxP3. In combination, the T cell–intrinsic and –extrinsic defects provide plausible explanation for the severity of the autoimmune diseases in the scurfy mice and in patients who have immunodysregulation, polyendocrinopathy, enteropathy, and X-linked syndrome.
Enhanced mast cell activation in mice deficient in the A2b adenosine receptor
Creators: name: Nguyen, My Trang
name: Hua, Xiaoyang
name: Chason, Kelly D.
name: Koller, Beverly H.
name: Tilley, Stephen L.
name: Kovarova, Martina
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Antigen-mediated cross-linking of IgE bound to mast cells via the high affinity receptor for IgE triggers a signaling cascade that results in the release of intracellular calcium stores, followed by an influx of extracellular calcium. The collective increase in intracellular calcium is critical to the release of the granular contents of the mast cell, which include the mediators of acute anaphylaxis. We show that the sensitivity of the mast cell to antigen-mediated degranulation through this pathway can be dramatically influenced by the A2b adenosine receptor. Loss of this Gs-coupled receptor on mouse bone marrow–derived mast cells results in decreased basal levels of cyclic AMP and an excessive influx of extracellular calcium through store-operated calcium channels following antigen activation. Mice lacking the A2b receptor display increased sensitivity to IgE-mediated anaphylaxis. Collectively, these findings show that the A2b adenosine receptor functions as a critical regulator of signaling pathways within the mast cell, which act in concert to limit the magnitude of mast cell responsiveness when antigen is encountered.
(1882) Thomas White
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
CARING pH and Total Alkalinity Data Report. FIGURE-CARING cruise 21-30 Jul 2022
Creators: name: Fajar, Noelia M.
name: Carracedo, Lidia I.
name: López-Mozos, Marta
name: Álvarez, Maria-Jesús
Publisher: name: Ifremer
Year: 2022

description: During the FIGURE-CARING cruise (https://doi.org/10.17600/18002940) on board the RV/Atlantic Explorer (21-30 Jul 2022), CTD-rosette discrete water samples were taken to measure pH and total alkalinity (TA), by means of a JASCO V-750 double beam spectrophotometer and an automatic potentiometric titrator "Titrando 809 Metrohm", respectively. The first, located in the air-conditioned RV/AE laboratory (End Lab), the latter, located ashore at the Institute of Marine Research (IIM-CSIC; Vigo, Spain). Further details on the water sampling/storage procedure can be found in the cruise report (Benavides and Carracedo, 2022; https://doi.org/10.13155/96692). The processing steps by parameter, as well as the QC and the final data, are described/shown in this data report. The corresponding datafile is provided as a CSV file (Carracedo et al., 2022; https://doi.org/10.17882/96728).
Memes als moderne Bildungsmedien: Humor als Medium pädagogischer Interaktion zur Wissenskonstruktion im Physikunterricht [Praxisbeitrag]
Creators: name: Prescher, Thomas
name: Thees, Michael
Publisher: name: bildungsforschung
Year: 2015

description: Memes stellen ein modernes Bildmedium dar. Im Beitrag wird die Frage verfolgt, ob Memes mit ihrem inhärenten Humor innerhalb des Unterrichts auch als Bildungsmedium dienen und didaktisch genutzt werden können. Dazu wird Humor als generalisiertes Kommunikationsmedium pädagogischer Interaktion beschrieben, um Memes als moderne Bildmedien - in ihrer Wirkung als humorvolle Form der affektiven und kognitiven Inkongruenzstiftung - zur Entwicklung von Fachkonzepten im Physikunterricht fassen zu können.
description: bildungsforschung, Bd. 1 (2015): Visuelle Bildungsmedien
The role played by citizen scientists in monitoring marine alien species in Greece
Creators: name: ZENETOS, Argyro
name: KOUTSOGIANNOPOULOS, David
name: OVALIS, Panayotis
name: POURSANIDIS, Dimitris
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2013

description: Environmental issues are best handled with the participation of all concerned citizens at the relevant level. Engaging citizen scientists to survey local biota and detect non-native marine species incursions is expected to result in the collection of significant data sets, which could potentially be used for an early-warning system inter alia. Our results suggest that such citizen support is beginning to develop in Greece, for invasive species such as the pufferfish Lagocephalus sceleratus; local newspapers often run a frontpage headline on the subject. Approximately 86 observations of 28 alien species (validated by taxonomic experts) were reported in 2012. Special mention is given to the following species, which until now had a very restricted distribution: Atherinomorus forskalii, Callionymus filamentosus, Smaragdia souverbiana and Cylichnina girardi. Concerned and informed citizens can participate personally in identifying incipient invaders and preventing them from spreading.
Fast production of Bose-Einstein condensates of metastable Helium
Creators: name: Bouton, Q.
name: Chang, R.
name: Hoendervanger, A. L.
name: Nogrette, F.
name: Aspect, A.
name: Westbrook, C. I.
name: Clément, D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We report on the Bose-Einstein condensation of metastable Helium-4 atoms using a hybrid approach, consisting of a magnetic quadrupole and a crossed optical dipole trap. In our setup we cross the phase transition with 2x10^6 atoms, and we obtain pure condensates of 5x10^5 atoms in the optical trap. This novel approach to cooling Helium-4 provides enhanced cycle stability, large optical access to the atoms and results in production of a condensate every 6 seconds - a factor 3 faster than the state-of-the-art. This speed-up will dramatically reduce the data acquisition time needed for the measurement of many particle correlations, made possible by the ability of metastable Helium to be detected individually.
THOMAS TROTTER. Essay, Medical, Philosophical and Chemical on Drunkenness. An Early Medical View of Alcohol Addiction and its Treatment.
Creators: name: Jellinek, E. M. (Elvin Morton)
Publisher: name: No Publisher Supplied
Year: 1941

description: An article published in the Quarterly Journal of Studies on Alcohol and in the volume entitled Classics of the Alcohol Literature, the primary source of many seminal articles related to Alcohol Studies.