cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Benefits of an Herbal-amino Acid Supplement in Osteoarthritis: Results of a Randomized Double-Blind Placebo Controlled Trial
Creators: name: Miller, Mark J. S.
Publisher: name: Zenodo
Year: 2021
Subjects: Animal models
dietary supplement
cat's claw
L-Leucine
Boswellia serrata
Maca
Uncaria tomentosa
Lepidium meyenii
inflammation
cartilage
flexibility
pain
quality of life
stiffness
arthritis
nutraceutical
natural product

description: Osteoarthritis is the most common form of joint disease and reflects a chronic inflammation that over time can result in joint destruction including the loss of articular cartilage and exposure of underlying bone. In a multi-center, randomised, placebo-controlled, double-blind clinical trial, a medicinal plant and L-leucine mixture (HLM) was studied in subjects with established osteoarthritis of the knee. A total of 96 osteoarthritic subjects were enrolled and randomly assigned to either a placebo (n = 38) or an HLM treatment group (n = 38). The HLM group received a combination of Uncaria tomentosa (300 mg), Boswellia serrata (200 mg), Lepidium meyenii (1000 mg) and L-Leucine (700 mg) once a day. The placebo group received matching capsules with carboxymethylcellulose. The treatment lasted eight weeks, with assessments on days seven, fourteen, twenty-eight, and fifty six.The primary goal was to lower the total WOMAC score.VAS pain, tolerability, investigator assessments, use of rescue medication (acetominophen), and vital sign and laboratory assessments were all included.Subject randomization worked well in terms of age, gender, and disease severity. The trial was completed by 32/38 subjects in the placebo group and 35/38 in the HLM group. WOMAC scores (pain, stiffness, physical performance, and total) decreased steadily in both groups over the course of the 8-week study, but the magnitude was significantly greater in HLM (P 0.05). Total WOMAC was reduced 46.5% for HLM and 25.4% for placebo. VAS pain was reduced 21.8% in the placebo group (p < 0.002) but the changes were significantly greater (37.8% p < 0.03) with HLM treatment. The investigator's overall rating of good-excellent for HLM was 24/35 (69%) and 14/32 (44%) for placebo (P = 0.05).The consumption and tolerability of rescue medications were comparable for HLM and placebo. These properties of HLM warranted a clinical investigation to further investigate its potential as a treatment for osteoarthritis, which is the focus of this report. There were no safety concerns with either group.Although a placebo effect was observed, HLM was clearly more effective in relieving osteoarthritis symptoms. This HLM represents a new, safe, and effective approach to managing osteoarthritis symptoms.
Additional file 1: of Diabetes policies and pharmacy-based diabetes interventions in Portugal: a comprehensive review
Creators: name: Costa, Suzete
name: Horta, Maria
name: Santos, Rita
name: Zilda Mendes
name: Jacinto, Isabel
name: JosĂŠ Guerreiro
name: Cary, Maria
name: Miranda, Ana
name: Helling, Dennis
name: Martins, Ana
Publisher: name: figshare
Year: 2019
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Science Policy

description: Search Strategy for Embase and MEDLINE (via Ovid). (DOC 23 kb)
Cosmological Black Holes
Creators: name: Stornaiolo, Cosimo
Publisher: name: arXiv
Year: 2001
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: In this paper we propose a model for the formation of the cosmological voids. We show that cosmological voids can form directly after the collapse of extremely large wavelength perturbations into low-density black holes or cosmological black holes (CBH). Consequently the voids are formed by the comoving expansion of the matter that surrounds the collapsed perturbation. It follows that the universe evolves, in first approximation, according to the Einstein-Straus cosmological model. We discuss finally the possibility to detect the presence of these black holes through their weak and strong lensing effects and their influence on the cosmic background radiation.
description: 14 pages, new completely revised version, to appear on GRG
Thermoelectric transport in two-dimensional topological insulator state based on HgTe quantum well
Creators: name: Gusev, G. M.
name: Raichev, O. E.
name: Olshanetsky, E. B.
name: Levin, A. D.
name: Kvon, Z. D.
name: Mikhailov, N. N.
name: Dvoretsky, S. A.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The thermoelectric response of HgTe quantum wells in the state of two-dimensional topological insulator (2D TI) has been studied experimentally. Ambipolar thermopower, typical for an electron-hole system, has been observed across the charge neutrality point, where the carrier type changes from electrons to holes according to the resistance measurements. The hole-type thermopower is much stronger than the electron-type one. The thermopower linearly increases with temperature. We present a theoretical model which accounts for both the edge and bulk contributions to the electrical conductivity and thermoelectric effect in a 2D TI, including the effects of edge to bulk leakage. The model, contrary to previous theoretical studies, demonstrates that the 2D TI is not expected to show anomalies of thermopower near the band conductivity threshold, which is consistent with our experimental results. Based on the experimental data and theoretical analysis, we conclude that the observed thermopower is mostly of the bulk origin, while the resistance is determined by both the edge and bulk transport.
description: 21 pages, 7 figures
КОММУНИКАТИВНЫЕ ОСНОВЫ СОВРЕМЕННЫХ ПОДХОДОВ ИЗУЧЕНИЯ РУССКОГО ЯЗЫКА В НАЧАЛЬНОЙ ШКОЛЕ
Creators: name: Арысланбаева, Анора
Publisher: name: Zenodo
Year: 2025

description: В данной статье рассматривается вопросы взаимоотношения преподавателя со студентами повышения профессиональных качеств и организационных моделей квалификации у студентов на основе коммуникативно - деятельностного подхода к образовательному процессу, важность  избирательного запоминания, волевого и умственного напряжения, эмоциональный подъём, развитие воображение как студентов, так и преподавателей.
Density-functional theory for attraction between like-charged plates
Creators: name: Diehl, A.
name: Tamashiro, M. N.
name: Barbosa, Marcia C.
name: Levin, Yan
Publisher: name: arXiv
Year: 1999
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We study the interactions between two negatively charged macroscopic surfaces confining positive counterions. A density-functional approach is introduced which, besides the usual mean-field interactions, takes into account the correlations in the positions of counterions. The excess free energy is derived in the framework of the Debye-H{ü}ckel theory of the one-component plasma, with the homogeneous density replaced by a weighted density. The minimization of the total free energy yields the density profile of the microions. The pressure is calculated and compared with the simulations and the results derived from integral equations theories. We find that the interaction between the two plates becomes attractive when their separation distance is sufficiently small and the surface charge density is larger than a threshold value.
description: 7 pages, 4 Postscript figures, uses multicol.sty
High dynamic range, heterogeneous, terahertz quantum cascade lasers featuring thermally-tunable frequency comb operation over a broad current range
Creators: name: Garrasi, Katia
name: Mezzapesa, Francesco P.
name: Salemi, Luca
name: Li, Lianhe
name: Consolino, Luigi
name: Bartalini, Saverio
name: De Natale, Paolo
name: Davies, A. Giles
name: Linfield, Edmund H.
name: Vitiello, Miriam S.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Applied Physics (physics.app-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We report on the engineering of broadband quantum cascade lasers (QCLs) emitting at Terahertz (THz) frequencies, which exploit a heterogeneous active region scheme and have a current density dynamic range (Jdr) of 3.2, significantly larger than the state of the art, over a 1.3 THz bandwidth. We demonstrate that the devised broadband lasers operate as THz optical frequency comb synthesizers in continuous wave, with a maximum optical output power of 4 mW (0.73 mW in the comb regime). Measurement of the intermode beatnote map reveals a clear dispersion-compensated frequency comb regime extending over a continuous 106 mA current range (current density dynamic range of 1.24), significantly larger than the state of the art reported under similar geometries, with a corresponding emission bandwidth of 1.05 THz ans a stable and narrow (4.15 KHz) beatnote detected with a signal-to-noise ratio of 34 dB. Analysis of the electrical and thermal beatnote tuning reveals a current-tuning coefficient ranging between 5 MHz/mA and 2.1 MHz/mA and a temperature-tuning coefficient of -4 MHz/K. The ability to tune the THz QCL combs over their full dynamic range by temperature and current paves the way for their use as powerful spectroscopy tool that can provide broad frequency coverage combined with high precision spectral accuracy.
A Comparative Study of Quality and Content-Based Spatial Pooling Strategies in Image Quality Assessment
Creators: name: Temel, Dogancan
name: AlRegib, Ghassan
Publisher: name: arXiv
Year: 2018
Subjects: subject: Image and Video Processing (eess.IV)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Multimedia (cs.MM)
subject: Signal Processing (eess.SP)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences
subject: I.4

description: The process of quantifying image quality consists of engineering the quality features and pooling these features to obtain a value or a map. There has been a significant research interest in designing the quality features but pooling is usually overlooked compared to feature design. In this work, we compare the state of the art quality and content-based spatial pooling strategies and show that although features are the key in any image quality assessment, pooling also matters. We also propose a quality-based spatial pooling strategy that is based on linearly weighted percentile pooling (WPP). Pooling strategies are analyzed for squared error, SSIM and PerSIM in LIVE, multiply distorted LIVE and TID2013 image databases.
description: Paper: 5 pages, 8 figures, Presentation: 21 slides [Ancillary files]
МОЛИЯВИЙ ҲИСОБОТНИНГ ҲАЛҚАРО СТАНТДАРТЛАРИ АСОСИДА ДАРОМАД ВА ХАРАЖАТЛАРНИ ҲИСОБЛАШ
Creators: name: Ҳайитмуродов, Улубек Улаш ўғли
Publisher: name: Zenodo
Year: 2025

description: Ушбу мақола Ўзбекистон Республикасида долзарб бўлган тармоқлардан бири қишлоқ хўжалигидаги кластерларни фаолияти таҳлил қилинди. Бунга жаҳон иқтисодиётининг глобаллашуви ва халқаро молиявий ҳисобот стандартлари ролининг ортиб бораётгани ёрдам бермоқда.Ҳозирги даврга келиб давлатимиз томонидан тадбиркорлик фаолиятининг янги шароитларига ўтиш, бухгалтерия ҳисобининг асосий тамойилларини халқаро стандартларга яқинлаштириш мамлакатимизда молиявий натижаларни ҳисобга олишда биз учун янги консепцияни шакллантириш заруратини келтириб чиқарди. Шунингдек, кластерлар фаолиятини ривожлантириш бўйича таклифлар ишлаб чиқилди.
Glass transition in self organizing cellular patterns
Creators: name: Aste, Tomaso
name: Sherrington, David
Publisher: name: arXiv
Year: 1998
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: We have considered the dynamical evolution of cellular patterns controlled by a stochastic Glauber process determined by the deviations of local cell topology from that of a crystalline structure. Above a critical temperature evolution is towards a common equilibrium state from any initial configuration, but beneath this temperature there is a dynamical phase transition, with a start from a quasi-random state leading to non-equilibrium glassy freezing whereas an ordered start rests almost unchanged. A temporal persistence function decays exponentially in the high temperature equilibrating state but has a characteristic slow non-equilibrium aging-like behaviour in the low temperature glassy phase.
description: Added references, text minor changes
Additional file 4: of Is there a sex difference in postoperative prognosis of hepatocellular carcinoma?
Creators: name: Lai, Ming-Wei
name: Yu-De Chu
name: Chih-Lang Lin
name: Rong-Nan Chien
name: Ta-Sen Yeh
name: Tai-Long Pan
name: Po-Yuan Ke
name: Kwang-Hui Lin
name: Chau-Ting Yeh
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy

description: Table S4. Clinicopathological factors associated with overall survival in male and female HCC. The table lists univariate and multivariate analysis of clinicopathological factors associated with overall survival in HCC patients of different sexes. (PDF 91 kb)
title: Quantifying Oxidative Folding
Creators: name: Rettenbacher, Lukas Alexander
Publisher: name: University of Kent
Year: 2024

description: Proteins are involved in almost every known biological process. Their immensely diverse pool of functionalities is largely determined by their amino acid sequence, their three-dimensional structure and by additional modifications known as post translational modifications (PTMs). One of these PTMs is the disulfide bond (DSB) which can be formed between two cysteine amino acids via covalent bonding of two sulfur atoms. DSBs can be found in many important proteins such as antibodies and the processes involved in their formation have been intensely studied for decades. During this time, many - mostly qualitative - aspects of their formation and prevalence have been researched. The research described in this thesis combine parts of this immense existing knowledge and elevate our understanding of the quantitative aspects of DSB formation. The thesis introduction summarises much of this existing knowledge and current research trends are further outlined in a published review. In Chapter 1 the quantitative formation of DSBs in Escherichia coli has been modelled in order to describe and predict both host proteome and recombinant protein DSB formation. Chapter 2 expands our understanding of the DSB forming machinery in the important recombinant protein production host Komagataella phaffii (syn. Pichia pastoris). In the final Chapter, protein structure predictions by AlphaFold are used for predicting both qualitative and quantitative DSB levels in several model organisms.
Brief Overview of Maize Lethal Necrosis and the Molecular Basis of Variability in Concentrations of the Causal Viruses in Co-infected Maize Plant
Creators: name: L. A. O. Awata
name: B. E. Ifie
name: P. Tongoona
name: E. Danquah
name: M. B. Jumbo
name: Manje Gowda
name: P. W. Marchelo-D'ragga
name: Chelang'at Sitonik
name: L. M. Suresh
Publisher: name: Zenodo
Year: 2021
Subjects: Co-infection
MLN
MCMV
SCMV
maize
virus
synergism

description: Maize lethal necrosis (MLN) disease is new to Africa, first report was in Kenya in 2012, since then the disease has rapidly spread to most parts of eastern and central Africa region including Tanzania, Burundi, DRC Congo, Rwanda, Uganda, Ethiopia and similar symptoms were observed in South Sudan. Elsewhere, the disease was caused by infection of Maize Chlorotic Mottle Virus (MCMV) in combination with any of the potyviruses namely, maize dwarf mosaic virus (MDMV) and sugarcane mosaic virus (SCMV), and tritimovirus wheat streak mosaic virus (WSMV). In Africa, the disease occurs due to combined infections of maize by MCMV and SCMV, leading to severe yield losses. Efforts to address the disease spread have been ongoing. Serological techniques including enzyme-linked immuno-sorbent assay (ELISA), polymerase chain reaction (PCR), genome-wide association (GWAS) mapping and next generation sequencing have been effectively used to detect and characterize MLN causative pathogens. Various management strategies have been adapted to control MLN including use of resistant varieties, phytosanitary measures and better cultural practices. The prevalence and survival of plant viruses in the tropics and subtropics are enhanced by the ideal tropical temperature conditions and relative humidity that encourage perpetuation of both the viruses and their insect vectors. This review looks at the current knowledge on MLN causative viruses, genetic architecture and molecular basis underlying their synergistic interactions. Lastly, some research gaps towards MLN management will be identified. The information gathered may be useful for developing strategies towards future MLN management and maize improvement in Africa.
Additional file 2: of Cardiovascular and microvascular outcomes of glucagon-like peptide-1 receptor agonists in type 2 diabetes: a meta-analysis of randomized controlled cardiovascular outcome trials with trial sequential analysis
Creators: name: Zhang, Xiaowen
name: Shao, Fei
name: Zhu, Lin
name: Ze, Yuyang
name: Zhu, Dalong
name: Bi, Yan
Publisher: name: figshare
Year: 2018
Subjects: Cell Biology
Molecular Biology
Chemical Sciences not elsewhere classified
Developmental Biology
Science Policy

description: MOOSE checklist. (DOC 71 kb)
Triassodotes Sinitshenkova & Papier 2005
Creators: name: SINITSHENKOVA, NINA D.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Ephemeroptera
Misthodotidae
Triassodotes

description: Triassodotes Sinitshenkova & Papier, 2005   Type species. T. vogesiacus Sinitshenkova & Papier, 2005.
description: Published as part of SINITSHENKOVA, NINA D., 2021, A new mayfly species Triassodotes rasnitsyni sp. nov. of the family Misthodotidae Tillyard, 1932 (Insecta; Ephemerida, Permoplectoptera) from the Triassic deposits of Kuzbass, Russia, pp. 429-432 in Palaeoentomology 4 (5) on page 429, DOI: 10.11646/palaeoentomology.4.5.6, http://zenodo.org/record/5530294
Leptoproduction of J/psi
Creators: name: Fleming, Sean
name: Mehen, Thomas
Publisher: name: arXiv
Year: 1997
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We study leptoproduction of $J/ψ$ at large $Q^2$ within the nonrelativistic QCD (NRQCD) factorization formalism. The cross section is dominated by color-octet terms that are of order $α_s$. The color-singlet term, which is of order $α^2_s$, is shown to be a small contribution to the total cross section. We also calculate the tree diagrams for color-octet production at order $α^2_s$ in a region of phase space where there is no leading color-octet contribution. We find that in this regime the color-singlet contribution dominates. We argue that non-perturbative corrections arising from diffractive leptoproduction, higher twist effects, and higher order terms in the NRQCD velocity expansion should be suppressed as $Q^2$ is increased. Therefore, the color-octet matrix elements $< {\cal O}_8^ψ(^1S_0)>$ and $$ can be reliably extracted from this process. Finally, we point out that an experimental measurement of the polarization of leptoproduced $J/ψ$ will provide an excellent test of the NRQCD factorization formalism.
description: 33 pages latex. 10 figures. Uses revtex, epsf, and rotate macros. This paper is also available via the UW phenomenology archives at http://phenom.physics.wisc.edu/pub/preprints/
Energy Levels of One Dimensional Anharmonic Oscillator via Neural Networks
Creators: name: Mutuk, Halil
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In this work, we obtained energy levels of one dimensional quartic anharmonic oscillator by using neural network system. Quartic anharmonic oscillator is a very important tool in quantum mechanics and also in quantum field theory. Our results are in good agreement in high accuracy with the reference studies.
description: 5 pages, 3 figures
Microreversibility, fluctuations, and nonlinear transport in transistors
Creators: name: Gu, Jiayin
name: Gaspard, Pierre
Publisher: name: arXiv
Year: 2018
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We present a stochastic approach for charge transport in transistors. In this approach, the electron and hole densities are governed by diffusion-reaction stochastic differential equations satisfying local detailed balance and the electric field is determined with the Poisson equation. The approach is consistent with the laws of electricity, thermodynamics, and microreversibility. In this way, the signal amplifying effect of transistors is verified under their working conditions. We also perform the full counting statistics of the two electric currents coupled together in transistors and we show that the fluctuation theorem holds for their joint probability distribution. Similar results are obtained including the displacement currents. In addition, the Onsager reciprocal relations and their generalizations to nonlinear transport properties deduced from the fluctuation theorem are numerically shown to be satisfied.
Quantum fidelity measures for mixed states
Creators: name: Liang, Yeong-Cherng
name: Yeh, Yu-Hao
name: Mendonça, Paulo E. M. F.
name: Teh, Run Yan
name: Reid, Margaret D.
name: Drummond, Peter D.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Applications of quantum technology often require fidelities to quantify performance. These provide a fundamental yardstick for the comparison of two quantum states. While this is straightforward in the case of pure states, it is much more subtle for the more general case of mixed quantum states often found in practice. A large number of different proposals exist. In this review, we summarize the required properties of a quantum fidelity measure, and compare them, to determine which properties each of the different measures has. We show that there are large classes of measures that satisfy all the required properties of a fidelity measure, just as there are many norms of Hilbert space operators, and many measures of entropy. We compare these fidelities, with detailed proofs of their properties. We also summarize briefly the applications of these measures in teleportation, quantum memories, quantum computers, quantum communications, and quantum phase-space simulations.
description: 22 + 6 + 3.5 pages, 7 figures, 6 tables, several proofs
A Multichannel Real-Time Bioimpedance Measurement Device for Pulse Wave Analysis
Creators: name: Kusche, Roman
name: Klimach, Paula
name: Ryschka, Martin
Publisher: name: arXiv
Year: 2019
Subjects: subject: Medical Physics (physics.med-ph)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: Pulse wave analysis is an important method used to gather information about the cardiovascular system. Instead of detecting the pulse wave via pressure sensors, bioimpedance measurements can be performed to acquire minuscule changes in the conductivity of the tissue, caused by the pulse wave. This work presents a microcontroller-based bioimpedance measurement system, which has the capability to acquire impedance measurements from up to four independent channels simultaneously. By combining a problem-specific analog measurement circuit with a 24 bits analog-to-digital converter, the system is capable of acquiring 1000 impedances per second with a signal-to-noise ratio in a range from 92 to 96 dB. For data storage and analysis, the digitized data are sent via universal serial bus to a host PC. A graphical user interface filters and plots the data of all channels in real-time. The performance of the system regarding measuring constant impedances, as well as impedance changes over time is demonstrated. Two different applications for pulse wave analysis via multichannel bioimpedance measurements are presented. Additionally, first measurement results from a human subject are shown to demonstrate the system's applicability of analyzing the pulse wave morphology as well as the aortic pulse wave velocity.
Additional file 2: of Is there a sex difference in postoperative prognosis of hepatocellular carcinoma?
Creators: name: Lai, Ming-Wei
name: Yu-De Chu
name: Chih-Lang Lin
name: Rong-Nan Chien
name: Ta-Sen Yeh
name: Tai-Long Pan
name: Po-Yuan Ke
name: Kwang-Hui Lin
name: Chau-Ting Yeh
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy

description: Table S2. Clinicopathological factors associated with intrahepatic recurrence free survival in male and female HCC. The table lists univariate and multivariate analysis of clinicopathological factors associated with intrahepatic recurrence-free survival in HCC patients of different sexes. (PDF 91 kb)
Data from Human iPSC-derived cardiac myocytes and sympathetic neurons in disease modelling
Creators: name: Li, Ni
name: Edel, Michael
name: Liu, Kun
name: Denning, Chris
name: Betts, Jacob
name: Neely, Oliver C.
name: Li, Dan
name: Paterson, David J.
Publisher: name: The Royal Society
Year: 2023

description: Human-induced pluripotent stem cells (hiPSC) offer an unprecedented opportunity to generate model systems that facilitate a mechanistic understanding of human disease. Current differentiation protocols are capable of generating cardiac myocytes (hiPSC-CM) and sympathetic neurons (hiPSC-SN). However, the ability of hiPSC-derived neurocardiac co-culture systems to recapitulate the human phenotype in diseased modelling is still in its infancy. Here, we adapted current methods for efficient and replicable induction of hiPSC-CM and hiPSC-SN. Expression of cell-type-specific proteins were confirmed by flow cytometry and immunofluorescence staining. The utility of healthy hiPSC-CM was tested with pressor agents to develop a model of cardiac hypertrophy. Treatment with angiotensin II resulted in: (i) cell and nuclear enlargement, (ii) enhanced fetal gene expression and (iii) FRET-activated cAMP responses to adrenergic stimulation. Angiotensin II or KCl increased intracellular calcium transients in hiPSC-SN. Immunostaining in neurocardiac co-cultures demonstrated anatomical innervation to myocytes, where myocyte cytosolic cAMP responses were enhanced by forskolin compared to monocultures. In conclusion, human iPSC-derived cardiac myocytes and sympathetic neurons recapitulated many features of the anatomy and (patho)physiology of these cells, where co-culture preparations behave in a manner that mimics key physiological responses seen in other mammalian systems.This article is part of the theme issue ‘The heartbeat: its molecular basis and physiological mechanisms’.
Rupture of multiple parallel molecular bonds under dynamic loading
Creators: name: Seifert, Udo
Publisher: name: arXiv
Year: 2000
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Quantitative Biology (q-bio)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Biological adhesion often involves several pairs of specific receptor-ligand molecules. Using rate equations, we study theoretically the rupture of such multiple parallel bonds under dynamic loading assisted by thermal activation. For a simple generic type of cooperativity, both the rupture time and force exhibit several different scaling regimes. The dependence of the rupture force on the number of bonds is predicted to be either linear, like a square root or logarithmic.
description: 8 pages, 2 figures
Psychological Impact during the Late Phase of Covid-19 Pandemic among the Hospitalised Patients and General Public in Andhra Pradesh - A Cross-Sectional Comparative Study
Creators: name: Donthu, Raj Kiran
Publisher: name: figshare
Year: 2021
Subjects: Health Care

description: Coronavirus disease 2019 (Covid-19) is a novel coronavirus, which became a pandemic within few days. Being a novel virus, the disease pathophysiology and psychological impact are not completely known. Studies conducted till nowconcentrated on the initial phases of the pandemic. Our study tries to understand the psychological impact during the late phase of the pandemic.
All-optical signatures of quantum vacuum nonlinearities in generic laser fields
Creators: name: Blinne, Alexander
name: Gies, Holger
name: Karbstein, Felix
name: Kohlfürst, Christian
name: Zepf, Matt
Publisher: name: arXiv
Year: 2018
Subjects: subject: Optics (physics.optics)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: All-optical experiments at the high-intensity frontier offer a promising route to unprecedented precision tests of quantum electrodynamics in strong macroscopic electromagnetic fields. So far, most theoretical studies of all-optical signatures of quantum vacuum nonlinearity are based on simplifying approximations of the beam profiles and pulse shapes of the driving laser fields. Since precision tests require accurate quantitative theoretical predictions, we introduce an efficient numerical tool facilitating the quantitative theoretical study of all-optical signatures of quantum vacuum nonlinearity in generic laser fields. Our approach is based on the vacuum emission picture, and makes use of the fact that the dynamics of the driving laser fields are to an excellent approximation governed by classical Maxwell theory in vacuum. In combination with a Maxwell solver, which self-consistently propagates any given laser field configuration, this allows for accurate theoretical predictions of photonic signatures of vacuum nonlinearity in high-intensity laser experiments from first principles. We employ our method to simulate photonic signatures of quantum vacuum nonlinearity in laser pulse collisions involving a few-cycle pulse, and show that the angular and spectral distributions of the emitted signal photons deviate from those of the driving laser beams.
description: 17 pages,9 figures
The hematite (alpha-Fe_2 O_3) (0001) surface: evidence for domains of distinct chemistry
Creators: name: Wang, X. -G.
name: Weiss, W.
name: Shaikhutdinov, Sh. K.
name: Ritter, M.
name: Petersen, M.
name: Wagner, F.
name: Schloegl, R.
name: Scheffler, M.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Using spin-density functional theory we investigated various possible structures of the hematite (0001) surface. Depending on the ambient oxygen partial pressure, two geometries are found to be particularly stable under thermal equilibrium: one being terminated by iron and the other by oxygen. Both exhibit huge surface relaxations (-57 % for the Fe- and -79 % for the O-termination) with important consequences for the surface electronic and magnetic properties. With scanning tunneling microscopy we observe two different surface terminations coexisting on single crystalline alpha-Fe_2 O_3 (0001) films, which were prepared in high oxygen pressures.
description: 4 pages, 3 figures, appears in Phys. Rev. Lett. (August 1998). Other related publications can be found at http://www.rz-berlin.mpg.de/th/paper.html
Additional file 3: of Is there a sex difference in postoperative prognosis of hepatocellular carcinoma?
Creators: name: Lai, Ming-Wei
name: Yu-De Chu
name: Chih-Lang Lin
name: Rong-Nan Chien
name: Ta-Sen Yeh
name: Tai-Long Pan
name: Po-Yuan Ke
name: Kwang-Hui Lin
name: Chau-Ting Yeh
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Table S3. Clinicopathological factors associated with distant metastasis free survival in male and female HCC. The table lists univariate and multivariate analysis of clinicopathological factors associated with distant metastasis free survival in HCC patients of different sexes, (PDF 91 kb)
STRATEGIC PLANNING IN THE CONTEXT OF ECONOMIC CHANGES
Creators: name: Tukhliyev, Bakhtiyor
Publisher: name: Zenodo
Year: 2025

description: This article examines the characteristics of strategic management in small and medium-sized enterprises (SMEs). It identifies the theoretical, methodological, and practical foundations for forming and implementing strategic management technologies and explores their application in innovative activities. The study analyzes existing challenges and prospects associated with the use of strategic management methods in the new economic environment.
Joule-level high effiency energy transfer to sub-picosecond laser pulses by a plasma-based amplifier
Creators: name: Marquès, J. -R.
name: Lancia, L.
name: Gangolf, T.
name: Blecher, M.
name: Bolaños, S.
name: Fuchs, J.
name: Willi, O.
name: Amiranoff, F.
name: Berger, R. L.
name: Chiaramello, M.
name: Weber, S.
name: Riconda, C.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: Laser plasma amplification of sub-picosecond pulses above the Joule level is demonstrated, a major milestone for this scheme to become a solution for the next-generation of ultra-high intensity lasers. By exploring over 6 orders of magnitude the influence of the incident seed intensity on Brillouin laser amplification, we reveal the importance of a minimum intensity to ensure an early onset of the self-similar regime, and a large energy transfer with a very high efficiency, up to 20%. Evidence of energy losses of the seed by spontaneous backward Raman is found at high amplification. The first three-dimensional envelope simulations of the sub-picosecond amplification were performed, supplemented by one-dimensional PIC simulations. Comparisons with the experimental results demonstrate the capability of quantitative predictions on the transferred energy. The global behavior of the amplification process, is reproduced, including the evolution of the spatial profile of the amplified seed.
Convergent Approximation for the 2-Body Correlation Function in an Interface
Creators: name: Ispolatov, Iaroslav
Publisher: name: arXiv
Year: 1999
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: A convergent approximation is proposed for a mean field density-density correlation function in a system with a two-phase interface. It is based on a fourth-order expansion of the Hamiltonian in terms of fluctuations around the equilibrium profile. The approach is illustrated by one and three dimensional calculations for systems characterized by the Ginzburg-Landau functional.
description: 10 pages, 2 figures
Additional file 1: of Assessing changing weather and the El Niño Southern Oscillation impacts on cattle rabies outbreaks and mortality in Costa Rica (1985–2016)
Creators: name: Hutter, Sabine
name: Käsbohrer, Annemarie
name: González, Silvia
name: León, Bernal
name: Brugger, Katharina
name: Baldi, Mario
name: Mario Romero, L.
name: Gao, Yan
name: Chaves, Luis
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Figure S1. Temporal patterns of cattle rabies outbreak mortality in Costa Rica (1985–2016). (A) Annual time series of cattle deaths from 1985 to 2016. Peak values occurred in 1985 and 2003, with 149 and 193 cattle deaths, respectively. (B) Bar chart of monthly cumulative cattle deaths from 1985-2016. The highest number of deaths occurred in April and July. (C) Monthly time series of cattle deaths from 1985 to 2016. It reflects both outbreaks during a year and cattle rabies deaths per month. Peak values occurred in 1985 and 2003. Note that in year 1995, although there is no peak value of cattle rabies death, there were many small outbreaks. (D) Boxplots of monthly cattle rabies deaths from 1985 to 2016. For all months from January to December, the median value of the boxplots is 0, which suggests that there is no seasonality in monthly cattle rabies deaths. (PDF 19 kb)
What Do Non-Psychiatric Doctors of Andhra Pradesh Think about Psychiatrists, Psychiatric Medications and Mental Illness? A Cross-Sectional Study
Creators: name: Donthu, Raj Kiran
Publisher: name: figshare
Year: 2021
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences

description: Mental and behavioural disorders are prevalent in all societies. The stigma and poor attitude towards mental illness and those with mental illness is well known. Similarly, there also exists poor opinions about psychiatrists and psychiatric medications among people. Non psychiatric doctors act as a bridge between the psychiatrists and mentally ill people. This study was conducted to evaluate the attitudes of non-psychiatric doctors towards psychiatrists, psychiatric medications, and mental illness.
Madygembia ARISTOV & STOROZHENKO 2021, gen. nov.
Creators: name: ARISTOV, DANIIL S.
name: STOROZHENKO, SERGEY YU.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Embioptera
Alexarasniidae
Madygembia

description: Genus Madygembia Aristov & Storozhenko, gen. nov.
 Type species. Madygembia rasnitsyni sp. nov., here designated.
 Etymology. The new genus is named after the Madygen locality and genus Embia. Gender feminine.
 Diagnosis. Forewings characters only. Sc reaching distal quarter of wing. RS arising near proximal third of wing and forming a long fusion (anastomosis) with MA. MP simple, desclerotized near middle. CuA with four branches directed to posterior margin of wing. Cross-veins numerous, simple. Wing membrane with wide hyaline intervenal lines.
 Remarks. New genus is most similar to Nestorembia but differs from latter in characters given above in the key.
description: Published as part of ARISTOV, DANIIL S. & STOROZHENKO, SERGEY YU., 2021, A new genus of the family Alexarasniidae (Insecta: Embiida) from the Triassic of Kyrgyzstan, pp. 433-435 in Palaeoentomology 4 (5) on page 434, DOI: 10.11646/palaeoentomology.4.5.7, http://zenodo.org/record/5530302
MOESM1 of Identifying the functions and biomarkers of Codonopsis pilosula and Astragalus membranaceus aqueous extracts in hepatic cells
Creators: name: Pin-Hao Ko
name: Chiung-Wei Huang
name: Hen-Hong Chang
name: Chuang, Eric
name: Mong-Hsun Tsai
name: Liang-Chuan Lai
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer

description: Additional file 1. Minimum standards of reporting checklist.
Spin-phonon coupling in hole-doped pyrochlore iridates Y$_2$(Ir$_{1-x}$Ru$_x$)$_2$O$_7$: A Raman scattering study
Creators: name: Kumar, Harish
name: Sathe, V. G.
name: Pramanik, A. K.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Temperature dependent Raman scattering measurements have been performed to explore unusual coupling between magnetism and crystal structure in doped pyrochlore iridate Y$_2$(Ir$_{1-x}$Ru$_x$)$_2$O$_7$ with $x$ = 0.0, 0.05 and 0.2. The parent Y$_2$Ir$_2$O$_7$ shows an onset of magnetic ordering around $\sim$ 160 K ($T_{N}$) which monotonically decreases with Ru doping. Further, magnetic moment also decreases with progressive substitution of Ru. Substitution of Ru$^{4+}$ (4$d^4$) for Ir$^{4+}$ (5$d^5$) does not introduce significant modification in structural parameters, however, the magnetic transition temperature decreases systematically with doping. Raman scattering data show an anomalous change in $A_{1g}$ and $P_3$ Raman mode frequency and line-width across $T_{N}$ of individual samples. We further show that the shifting of Raman mode frequency with temperature exhibits a strong deviation from anharmonic decay around and below the $T_{N}$ of respective samples which underlines a spin-phonon coupling in these materials.
description: To appear in JMMM, 10 pages, 9 figures
Lack of association between TNFA and TNFB polymorphisms and the risk of multiple sclerosis: a meta-analysis from 37 studies
Creators: name: Gu, Jiebing
name: Sun, Jing
name: Zhang, Yingyu
name: Wang, Xiaoshuang
name: Fu, Lingling
name: Li, Linfang
name: Wang, Di
name: Wang, Xiuting
name: Yu, Le
name: Han, Xuemei
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: Epidemiological studies about the association between genetic polymorphisms in TNFA, TNFB, and IFNG and the risk for multiple sclerosis (MS) have been performed extensively. However, the results are inconclusive. The purpose of this meta-analysis was to evaluate the contribution of the polymorphisms in TNFA, TNFB, and IFNG to the susceptibility of MS. The PubMed, Web of Science, and China National Knowledge Infrastructure databases were searched to identify relevant studies up to October 2021. A meta-analysis was performed, and pooled odds ratios (OR) and confidence intervals (CI) were computed using fixed or random effects models. A marginally significant association of the IFNG +874AT genotype with high risk of MS was observed in a heterozygous comparison (OR = 1.51, 95% CI, 1.02–2.23). However, no significant association between the TNFA (–308 G/A, – 238 G/A, and – 376 G/A) and TNFB +252A/G polymorphisms and MS risk was observed both in overall analysis and in subgroup analysis. This meta-analysis provides evidence that the TNFA (–308 G/A, – 238 G/A, and – 376 G/A) and TNFB +252A/G polymorphisms were not risk factors for the occurrence of MS. Further studies with larger samples are necessary to reach the concise results about the contribution of other polymorphisms to the risk of MS.
Association of Big Five Personality with Perceived Stress in Medical Postgraduates A Cross-sectional Study
Creators: name: Donthu, Raj Kiran
Publisher: name: figshare
Year: 2021
Subjects: Clinical Psychology
Personality, Social and Criminal Psychology

description: Medical postgraduates are exposed to more time in patient care and thereby higher stress. Personality is one of the important factors associated with stress. Studies exist in profiling personality traits and also assessing stress in medical professionals. However, in India, to the best of our knowledge, there are only few studies linking personality traits with stress in different branches of medicine.
On The Possible Detection Of Massive Stable Exotic Particles At The LHC
Creators: name: Nisati, Aleandro
name: Petrarca, Silvano
name: Salvini, Giorgio
Publisher: name: arXiv
Year: 1997
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The possible detection of massive quasi-stable exotic particles at the high luminosity hadronic colliders is discussed. In the coming ten years the LHC, now under preparation, has the best opportunity to observe them at the TeV scale. The present design of the ATLAS detector,that has been almost irreversibly decided, may turn out to be flexible enough to allow the detection of this interesting class of exotic particles. The trigger acceptance, the track reconstruction and the particle identification are studied. The necessity of a good measurement of the ionization loss in the muon sector of the detectors is recommended.
description: 12 Latex pages, 4 figures JPEG
Additional file 1: of Barriers to and facilitators of the development and utilization of context appropriate evidence based clinical algorithms to optimize clinical care and patient outcomes in the TikurÂ Anbessa emergency department: a multi-component qualitative study
Creators: name: Ritchie, Lisa Puchalski
name: Finot Debebe
name: Aklilu Azazh
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Interview Guide. (PDF 52 kb)
Additional file 4: of Assessing changing weather and the El Niño Southern Oscillation impacts on cattle rabies outbreaks and mortality in Costa Rica (1985–2016)
Creators: name: Hutter, Sabine
name: Käsbohrer, Annemarie
name: González, Silvia
name: León, Bernal
name: Brugger, Katharina
name: Baldi, Mario
name: Mario Romero, L.
name: Gao, Yan
name: Chaves, Luis
Publisher: name: figshare
Year: 2018
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Figure S4. Correlation functions. (A) Auto-correlation function (ACF) of the monthly cattle rabies outbreak number time series; it shows the data were not strongly auto-correlated. (B) Partial auto-correlation function (PACF) of the monthly cattle rabies outbreaks time series data shows that there is a periodicity of 3 months. (C) Cross-correlation function (CCF) of the monthly cattle rabies outbreak number time series data with the ENSO4 index data. This CCF shows no significant linear association over the studied period, when considering up to 22 months of lag. (D) ACF of the monthly outbreak mortality time series. This time series shows low autocorrelation. (E) PACF of the monthly outbreak mortality time series. This time series shows a periodicity of 2 months. (F) CCF of the monthly outbreak mortality time series data with the ENSO4 index data. This CCF shows no significant linear association over the studied period, when considering up to 22 months of lag. In all panels blue dashed lines indicate the 95% confidence limits for correlations that can be expected by random. (PDF 17 kb)
Oxcarbazepine‑induced Steven–Johnson syndrome
Creators: name: Donthu, Raj Kiran
Publisher: name: figshare
Year: 2021
Subjects: subject: Health Care
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Carbamazepine has been well documented to be associated with Steven–Johnson Syndrome (SJS). The newer anti‑epileptic oxcarbazepine has not been demonstrated to be associated with this rare side effect except in some case reports. We present a case of SJS caused due to use of oxcarbazepine in a patient of schizophrenia.