cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A Threefold RNA–Protein Interface in the Signal Recognition Particle Gates Native Complex Assembly
Creators: name: Maity, Tuhin Subhra
name: Weeks, Kevin M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Intermediate states play well established roles in the folding and misfolding reactions of individual RNA and protein molecules. In contrast, the roles of transient structural intermediates in multi-component ribonucleoprotein (RNP) assembly processes and their potential for misassembly are largely unexplored. The mammalian signal recognition particle SRP19 protein is unstructured but forms a compact core domain and two extended RNA-binding loops upon binding the SRP RNA. The SRP54 protein subsequently binds to the fully assembled SRP19-RNA complex to form an intimate three-fold interface with both SRP19 and the SRP RNA and without significantly altering the structure of SRP19. We show, however, that the presence of SRP54 during SRP19-SRP RNA assembly dramatically alters the folding energy landscape to create a non-native folding pathway that leads to an aberrant SRP19-RNA conformation. The misassembled complex arises from the surprising ability of SRP54 to bind rapidly to an SRP19-RNA assembly intermediate and to interfere with subsequent folding of one of the SRP19 RNA-binding loops at the three-way protein-RNA interface. An incorrect temporal order of assembly thus readily yields a non-native three-component ribonucleoprotein particle. We propose there may exist a general requirement to regulate the order of interaction in multi-component RNP assembly by spatial or temporal compartmentalization of individual constituents in the cell.
Memristive Threshold Logic Circuit Design of Fast Moving Object Detection
Creators: name: Maan, Akshay Kumar
name: Kumar, Dinesh Sasi
name: Sugathan, Sherin
name: James, Alex Pappachen
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Hardware Architecture (cs.AR)
subject: Emerging Technologies (cs.ET)
subject: FOS: Computer and information sciences

description: Real-time detection of moving objects involves memorisation of features in the template image and their comparison with those in the test image. At high sampling rates, such techniques face the problems of high algorithmic complexity and component delays. We present a new resistive switching based threshold logic cell which encodes the pixels of a template image. The cell comprises a voltage divider circuit that programs the resistances of the memristors arranged in a single node threshold logic network and the output is encoded as a binary value using a CMOS inverter gate. When a test image is applied to the template-programmed cell, a mismatch in the respective pixels is seen as a change in the output voltage of the cell. The proposed cell when compared with CMOS equivalent implementation shows improved performance in area, leakage power, power dissipation and delay.
description: To be published in IEEE Transactions on Very Large Scale Integration (VLSI) Systems
title: РОЛЬ НАУЧНО-ИННОВАЦИОННОЙ СФЕРЫ В СОЦИАЛЬНО-ЭКОНОМИЧЕСКОМ РАЗВИТИИ РОССИЙСКОЙ ФЕДЕРАЦИИ
Creators: name: Быкова, Маргарита
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: Статья посвящена исследованию влияния научно-инновационной сферы на социально-экономическое развитие Российской Федерации. Анализ работ отечественных и зарубежных авторов, относящихся к проблеме исследования, позволил выявить исключительную роль науки в формировании принципиально новой модели экономического развития. Значение инноваций на современном этапе развития страны состоит в создании предпосылок для сокращения имеющихся технологических разрывов и переходе к новой ступени социально-экономического развития. На основе системного подхода, ставшего методологической основой исследования, была предложена схема оценки состояния научно-инновационной сферы Российской Федерации. Предложенный подход включал в себя анализ шести комплексных показателей, разработанных на основе первичных статистических данных. Применение показателей отношений позволило существенно сократить массив анализируемых данных, сохранив при этом информативную составляющую.
ESDH-system
Creators: Kommissarius ved Statens Ekspropriationer på Øerne
Kommissarius ved Statens Ekspropriationer i Jylland
Publisher: name: Rigsarkivet
Year: 2025

description: WorkZone er et elektronisk sags- og dokumenthåndteringssystem (ESDH-system), der har til formål at sikre en hensigtsmæssig og gennemskuelig opdeling af Kommissariatets sager, hurtig fremfinding af sager og dokumenter, besvarelse af forespørgsler uden at skulle finde sager frem, fornøden opfølgning på verserende sager (erindringskontrol), konstatering af (manglende) modtagelse og afsendelse af post og nem udskillelse af sager, der ikke skal bevares.
title: Branchenreport UX/Usability 2022
Creators: name: Tretter, Stefan
name: Diefenbach, Sarah
name: Ullrich, Daniel
name: Gerber, Nina
Publisher: name: Gesellschaft für Informatik e.V.
Year: 2022
Subjects: subject: UX/Usability Branche
subject: Ausbildung
subject: Karriere
subject: Arbeitsfelder
subject: Gehalt
subject: Trends

description: Mit dem Branchenreport UX/Usability 2022 dokumentiert die German UPA (Berufsverband der deutschen Usability und User Experience Professionals) die Situation von Usability und User Experience Professionals in Deutschland. Auf Basis einer jährlichen Befragung liefert der Branchenreport Einblicke u.a. in Ausbildungs- und Karrierewege, Arbeitsfelder und Aufgabenbereiche, Verdienstmöglichkeiten, unternehmerische Aspekte, sowie aktuelle Trends und Potenziale. Zusätzliche Vergleiche mit vorherigen Jahren geben Aufschluss über Entwicklungen der Branche (z.B. Gehälter, Ausbildungswege, Tätigkeitsbereiche) im zeitlichen Verlauf.
title: Gynaecological Emergencies: CT Findings of Uterine and Adnexal Torsion
Creators: name: Cheong, Elizabeth, Hui Ting
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Acute
subject: Diagnostic procedure
subject: Education
subject: Ultrasound
subject: CT
subject: Pelvis
subject: Genital / Reproductive system female
subject: Emergency
subject: Ischaemia / Infarction

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Be aware that gynaecological emergencies can present with non-specific symptoms, and are thus often unsuspected Recognise CT features of uterine and ovarian torsion Confidently and accurately diagnose uterine and ovarian...
title: The Positive X – Jetzt packen wir es an!
Creators: name: Hermosa Perrino, Christina
name: Spohrer, Anika
name: Burmester, Michael
name: Köberlein, Marina
name: Brodbeck, Tanja
name: Zeiner, Katharina M.
name: Hammel, Katharina
name: Müller, Franziska
Publisher: name: Gesellschaft für Informatik e.V.
Year: 2022
Subjects: subject: Positive User Experience
subject: Positive Psychologie
subject: E-Commerce
subject: Arbeitskreis “The Positive X”
subject: Pattern
subject: Erlebnisinterviews
subject: Gestaltungslösungen

description: Als Arbeitskreis "The Positive X" beschäftigen wir uns mit der Frage, was die Positive User Experience (-UX) ausmacht. Die Wissenschaft der "Positiven Psychologie" schafft für uns eine Haltung, was wir mit der "Positiven UX" erzielen wollen. Schwerpunkte dieser Forschungsrichtung sind unter anderem die Untersuchung positiver Erlebnisse, Bedürfnisse, Emotionen, Wohlbefinden und Lebenszufriedenheit. Darüber hinaus beschäftigen wir uns mit den Grenzen, also wann ist es Positive UX und wann wird es negativ manipulativ (Evil-Design)? Die E-Commerce-Branche wird in diesem Rahmen oft als Beispiel diskutiert, da manipulierende Gestaltungslösungen gängig sind, die den Umsatz steigern sollen. In diesem Beitrag zeigen wir das Umsatzerzielung und-steigerung im E-Commerce nicht nur durch Evil-Design, sondern auch durch eine Positive UX erfolgen kann. Des Weiteren war unser diesjähriges Ziel, bewusst für Positive UX im E-Commerce Bereich zu gestalten. Wir beschreiben unser Vorgehen zur Gestaltung dieser positiven Erlebnisse. Aus mehreren Erlebnisinterviews wurden dazu typische psychologische Bedürfnisse analysiert, die beim Online-Shopping angesprochen werden. In einem Kreativworkshop wurden anhand des Beispiels des German UPA Online-Shops, neue Konzepte für positives Erleben entwickelt, die diese psychologischen Bedürfnisse erfüllen. Des Weiteren haben wir Interviews mit UX Professionals im E-Commerce durchgeführt. Die Ergebnisse geben einen Einblick, inwiefern Positive UX heute schon bewusst im Arbeitsalltag gelebt wird. Der Arbeitskreis "The Positive X" bietet den hier beschriebenen Workshop im Rahmen zukünftiger GermanUPA Veranstaltungen zum Ausprobieren an.
Assessment Model for Opportunistic Routing
Creators: name: Moreira, Waldir
name: Mendes, Paulo
name: Sargento, Susana
Publisher: name: arXiv
Year: 2014
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: This paper proposes an assessment model, based on a new taxonomy, which comprises an evaluation guideline with performance metrics and experimental setup to aid designers in evaluating solutions through fair comparisons. Simulation results are provided based on the proposed model considering Epidemic, PROPHET, Bubble Rap, and Spray and Wait, and showing how they perform under the same set of metrics and scenario
description: 6 pages, 5 figures, in Portuguese
Crystal Structure of the Cofactor-Binding Domain of the Human Phase II Drug-Metabolism Enzyme UDP-Glucuronosyltransferase 2B7
Creators: name: Radominska-Pandya, Anna
name: Redinbo, Matthew R.
name: Zielinska, Agnieszka K.
name: Bratton, Stacie M.
name: Keenan, Jeffrey E.
name: Miley, Michael J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Human UDP-glucuronosyltransferases (UGT) are the dominant phase II conjugative drug metabolism enzymes that also play a central role in the processing of a range of endobiotic compounds. UGTs catalyze the covalent addition of glucuronic acid sugar moieties to a host of therapeutics and environmental toxins, as well as to a variety of endogenous steroids and other signaling molecules. We report the 1.8 Å resolution apo crystal structure of the UDP-glucuronic acid binding domain of human UGT isoform 2B7 (UGT2B7), which catalyzes the conjugative elimination of opioid, antiviral, and anticancer drugs. This is the first crystal structure of any region of a mammalian UGT drug metabolism enzyme. Designed UGT2B7 mutants at residues predicted to interact with the UDP-glucuronic acid cofactor exhibited significantly impaired catalytic activity, with maximum effects observed for amino acids closest to the glucuronic acid sugar transferred to the acceptor molecule. Homology modeling of UGT2B7 with related plant flavonoid glucosyltransferases indicate that human UGTs share a common catalytic mechanism. Point mutations at predicted catalytic residues in UGT2B7 abrogated activity, strongly suggesting that human UGTs also utilize a serine hydrolase-like catalytic mechanism to facilitate glucuronic acid transfer.
Anisotropic Fabry-Pérot resonant states confined within nano-steps on the topological insulator surface
Creators: name: Fu, Zhen-Guo
name: Zhang, Ping
name: Chen, Mu
name: Wang, Zhigang
name: Zheng, Fa-Wei
name: Lin, Hai-Qing
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The peculiar nature of topological surface states, such as absence of backscattering, weak anti-localization, and quantum anomalous Hall effect, has been demonstrated mainly in bulk and film of topological insulator (TI), using surface sensitive probes and bulk transport probes. However, it is equally important and experimentally challenging to confine massless Dirac fermions with nano-steps on TI surfaces. This potential structure has similar ground with linearly-dispersed photons in Fabry-Pérot resonators, while reserving fundamental differences from well-studied Fabry-Pérot resonators and quantum corrals on noble metal surfaces. In this paper, we study the massless Dirac fermions confined within steps along the $x$ ($Γ\mathtt{-}$K) or $y$ ($Γ\mathtt{-}$M) direction on the TI surface, and the Fabry-Pérot-like resonances in the electronic local density of states (LDOS) between the steps are found. Due to the remarkable warping effect in the topological surface states, the LDOS confined in the step-well running along $Γ$-M direction exhibit anisotropic resonance patterns as compared to those in the step-well along $Γ$-K direction, which can be detected by scanning tunneling microscopy. The transmittance properties and spin orientation of Dirac fermion in both cases are also anisotropic in the presence of warping effect.
description: 10 pages, 8 figures
Crystal Structure of Tryptophanyl-tRNA Synthetase Complexed with Adenosine-5′ Tetraphosphate: Evidence for Distributed Use of Catalytic Binding Energy in Amino Acid Activation by Class I Aminoacyl-tRNA Synthetases
Creators: name: Retailleau, Pascal
name: Carter, Charles W.
name: Hu, Mei
name: Weinreb, Violetta
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Tryptophanyl-tRNA synthetase (TrpRS) is a functionally dimeric ligase, which specifically couples hydrolysis of ATP to AMP and pyrophosphate to the formation of an ester bond between tryptophan and the cognate tRNA. TrpRS from Bacillus stearothermophilus binds the ATP analogue, adenosine-5′ tetraphosphate, AQP, competitively with ATP during pyrophosphate exchange. Estimates of binding affinity from this competitive inhibition and from isothermal titration calorimetry show that AQP binds 200 times more tightly than ATP both under conditions of induced-fit, where binding is coupled to an unfavourable conformational change, and under exchange conditions, where there is no conformational change. These binding data provide an indirect experimental measurement of +3.0 kcal/mole for the conformational free energy change associated with induced-fit assembly of the active site. Thermodynamic parameters derived from the calorimetry reveal very modest enthalpic changes, consistent with binding driven largely by a favorable entropy change. The 2.5 Å structure of the TrpRS:AQP complex, determined de novo by X-ray crystallography, resembles that of the previously described, pre-transition state TrpRS:ATP complexes. The anticodon-binding domain untwists relative to the Rossmann-fold domain by 20% of the way toward the orientation observed for the Products complex. An unexpected tetraphosphate conformation allows the γ̃ and δ̃ phosphate groups to occupy positions equivalent to those occupied by the β̃ and γ̃ phosphates of ATP. The β-phosphate effects a 1.11 Å extension that relocates the α-phosphate toward the tryptophan carboxylate while the PPi mimic moves deeper into the KMSKS loop. This configuration improves interactions between enzyme and nucleotide significantly and uniformly in the adenosine and PPi binding subsites. A new hydrogen bond forms between S194 from the class I KMSKS signature sequence and the PPi mimic. These complementary thermodynamic and structural data are all consistent with the conclusion that the tetraphosphate mimics a transition-state in which the KMSKS loop develops increasingly tight bonds to the PPi leaving group, weakening linkage to the Pα as it is relocated by an energetically favourable domain movement. Consistent with extensive mutational data on Tyrosyl-tRNA synthetase, this aspect of the mechanism develops high transition-state affinity for the adenosine and pyrophosphate moieties, which move significantly, relative to one another, during the catalytic step.
Technical Requirements
Creators: name: All SECANT Partners
Publisher: name: Zenodo
Year: 2022
Subjects: cybersecurity
healthcare

description: This deliverable reports the technical requirements of the SECANT solution. In particular, D2.2 Technical Requirements is eliciting the technical requirements that the SECANT must satisfy from the SECANT end-user/stakeholder requirements reported in D2.1- End-user/stakeholder requirements and the SECANT use cases as were defined under D2.3 - Use cases analysis and application
 scenarios. Initially, the context of the SECANT project is defined through a high-level presentation of its main objectives and key technological areas. Next, an initial threat portfolio is established to build the basis for the development of the Threat Intelligence Module. Finally, concepts relating to the elicitation, prioritisation and refinement of functional and non-functional requirements are introduced to further contextualise the work and define the scope of the analysis for the rest of the document. The requirement elicitation methodology that was followed for the purposes of the activities described in this deliverable included the following: the interaction with technology providers via template documents for the description of their technological solutions and unstructured interviews for the refinement of their requirements the identification of relevant literature sources regarding the state-of-the-art of each SECANT component the process for the analysis, refinement, and categorisation of the elicited requirements Finally, the document provides a list of up to 150 grouped and prioritised requirements that were identified by the contributors of this deliverable.
title: Leitfaden der Konzeptprüfung nichtstaatlicher Hochschulen in Gründung
Creators: name: German Science And Humanities Council
Publisher: name: German Science and Humanities Council
Year: 2022
Subjects: institutionelle Akkreditierung
private Hochschulen
Qualitätssicherung nichtstaatlicher Hochschulen
Leitfaden Hochschulförmigkeit
Hochschulen
Konzeptprüfung
staatliche Anerkennung

description: Konzeptprüfung und Institutionelle Akkreditierung dienen den Ländern als Gutachten zur Erweiterung ihrer Entscheidungsgrundlage für die staatliche Anerkennungspraxis. In grundlegend überarbeiteter Fassung wurden auf den Sommersitzungen des Wissenschaftsrats in Magdeburg der „Leitfaden der Institutionellen Akkreditierung nichtstaatlicher Hochschulen“ sowie der „Leitfaden der Konzeptprüfung nichtstaatlicher Hochschulen in Gründung“ verabschiedet. Die Revision beider Leitfäden berücksichtigt insbesondere neue gesetzliche Regelungen der staatlichen Anerkennung nichtstaatlicher Hochschulen sowie der Institutionellen Akkreditierung. Anträge nach den bisherigen Leitfäden sind letztmalig zum 1. Dezember 2022 (Institutionelle Akkreditierung) bzw. dem 15. Januar 2023 (Konzeptprüfung) möglich.
title: Interaktive und Intelligente Karten für ein verbessertes Nutzererlebnis
Creators: name: Degbelo, Auriol
name: Gerkowski, Lars
name: Henzen, Christina
name: Lechler, Sarah
name: Linde, Stefanie
name: Lubahn, Birgitta
name: Maas, Felix
name: Schmitd, Benno
name: Zander, Franziska
Publisher: name: Gesellschaft für Informatik e.V.
Year: 2022
Subjects: subject: digitale geographische Karten
subject: interaktive Karten
subject: intelligente Karten

description: Interaktive digitale Karten sind für die Veranschaulichung und Analyse geographischer Daten hilfreich und werden für diverse Zwecke (z.B. Wegfindung, Datenjournalismus, Datenanalyse, Bürgerbeteiligung) eingesetzt. Dieser Workshop zielt darauf ab, einen Erfahrungsaustausch zu den Features, die den Umgang mit Karten erleichtern, zu fördern und kollaborativ Anforderungen für digitale Karten der Zukunft zu sammeln. Der Workshop wird von Mitgliedern des German UPA Arbeitskreises Geo UX organisiert.
title: A Pictorial Review of Common and Unusual Presentations of Epidermoid Cysts in the Central Nervous System
Creators: name: Barakat, Athar
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Neoplasia
subject: Education and training
subject: Cysts
subject: Imaging sequences
subject: Education
subject: Diagnostic procedure
subject: MR-Diffusion/Perfusion
subject: MR
subject: CT
subject: Oncology
subject: Neuroradiology spine
subject: Neuroradiology brain

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Review common imaging characteristics of epidermoid cysts. Learn to distinguish epidermoid cysts from similar space-occupying lesions. Demonstrate examples of common and unusual appearances of epidermoid...
Vacuum Thermal Switch Made of Phase Transition Materials Considering Thin Film and Substrate Effects
Creators: name: Yang, Yue
name: Basu, Soumyadipta
name: Wang, Liping
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: In the present study, we demonstrate a vacuum thermal switch based on near-field thermal radiation between phase transition materials, i.e., vanadium dioxide (VO2), whose phase changes from insulator to metal at 341 K. Similar modulation effect has already been demonstrated and it will be extended to thin-film structure with substrate in this paper. Strong coupling of surface phonon polaritons between two insulating VO2 plates significantly enhances the near-field heat flux, which on the other hand is greatly reduced when the VO2 emitter becomes metallic, resulting strong thermal switching effect. Fluctuational electrodynamics predicts more than 80% heat transfer reduction at sub-30-nm vacuum gaps and 50% at vacuum gap of 1 micron. By replacing the bulk VO2 receiver with a thin film of several tens of nanometers, the switching effect can be further improved over a broad range of vacuum gaps from 10 nm to 1 um. In addition, for the purpose of more practical setup in experiments and applications, the SiO2 substrate effect is also considered for the structure with thin-film emitter or receiver.
title: Tips for TIPS (Transjugular Intrahepatic Portosystemic Shunts) hemodynamic changes and Doppler ultrasound-guided functional evaluation
Creators: name: Kimura, Yukiyoshi
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Liver
subject: Veins / Vena cava
subject: Interventional vascular
subject: Ultrasound-Spectral Doppler
subject: Ultrasound-Power Doppler
subject: Ultrasound-Colour Doppler
subject: Screening
subject: Shunts
subject: Cirrhosis

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: • Understand the physiology of portal hemodynamics. • Describe portal hemodynamic changes after TIPS placement. • Recognize the ultrasonographic findings of TIPS...
Floyd Kuptana and American Pop Culture : Close Readings of  "Purpel Rain" and "Snoopy under Starry Sky" /  by Richard D. Mohr
Creators: name: Mohr, Richard D.
Publisher: name: Zenodo
Year: 2024
Subjects: subject: floyd kuptana
subject: richard mohr
subject: Arts
subject: Modern and contemporary art
subject: inuit art
subject: Popular music studies
subject: pop culture
subject: Prince
subject: Snoopy
subject: Van Gogh
subject: Starry Night
subject: Shaman
subject: Sedna

description: This is the recorded presentation with subtitles, and the original text file.

The late, Arctic-born, Toronto-based Inuit artist Floyd Kuptana ― best known as a carver ― in his 2-D works, made several hunting and gathering forays deep into distinctively American pop culture.

Richard D. Mohr is Professor Emeritus of Philosophy and of the Classics at the University of Illinois. Over the last few years, he has been writing and lecturing on Inuit art and ethnography. He is an academically trained author with extensive journalistic experience and literary flair. He publishes books in three widely diverse fields: ancient Greek metaphysics, especially Plato’s; American ceramics, especially from the Arts & Crafts period; and gay studies along with queer theory, focusing on ethical, social, political, and legal issues." (Source: Amazon https://www.amazon.com/stores/author/...

Also shared at the "Floyd Kuptana : From Another World" project site: https://floydkuptana.ca

 

See also:

"The Collages of Janet Kigusiuq : A Case Study in Inuit aesthetics" / with Richard D. Mohr Presentation at the Inuit Art Society 2024 Annual Meeting, August 16 & 17 in Traverse City, Michigan, United States.    • The Collages of Janet Kigusiuq : A Ca...  

"Floyd Kuptana Show-'n'-Tell" by Richard D. Mohr Talk by Richard D. Mohr about Floyd Kuptana. A five minute show-’n’-tell plus in-memorium for Floyd presented to the Inuit Art Society as a Zoom (June 13th 2021), two weeks after Floyd died. (May 27th 2021)    • Floyd Kuptana Show-and-Tell, by Richa...  

“Good Friday with Floyd Kuptana” by Richard Mohr (on April, 10th 2020, Good Friday)    • Good Friday with Floyd Kuptana / by R...  

 

#projectfloydkuptana #floydkuptana #inuitart #artinuit #artthatisreal #snoopy #richarddmohr #prince #popculture #metlife #galleryarcturus #arcturus #vangogh #starrynight #shaman #sedna #GalleryArcturus #RobertWSwitzer #eronboyd #LouJungheim #ThaliaNicas   #starrynight #sedna #arcturus
Multiliteracies and Multimodality in the SHL Classroom. A Workshop
Creators: name: Gironzetti, Elisa
name: Belpoliti, Flavia
Publisher: name: Digital Repository at the University of Maryland
Year: 2020
Subjects: Spanish as a heritage language
Multiliteracies
Multimodality

description: This workshop is organized to engage participants in the four stages (experiencing, conceptualizing, analyzing, and applying) of the “Learning by Design” multiliteracy pedagogy, with a focus on Spanish heritage language education. In the first part of the workshop, participants are introduced to the main principles of a pedagogy of multiliteracies (The New London Group 1996; Kalantzis & Cope 2008; Allen & Paesani, 2010; López-Sánchez, 2014; Kalantzis et al. 2016; Zapata & Lacorte 2016) through examples, reflection on teaching practices, and guided discussions. In this initial stage, the focus will be on discovering the tenets of a multiliteracies approach to language learning, as well as exploring different multimodal discourses and their suitability to teaching SHL student populations in a variety of educational contexts. In the second part of the workshop, participants will experience and analyze a sample set of teaching materials that have been successfully implemented in a Spanish HL university course. The experience phase of the workshop engages participants as students who learn within a multiliteracies framework. The analysis phase, on the other hand, promotes critical reflection on the student experience as well as a discussion of the design process of these teaching materials, from conception to implementation and assessment. In the final section, participants work in small groups to brainstorm and apply multiliteracies principles to design a learning unit that considers the specific needs of learners in their heritage and mixed classrooms.
Drosophila CTCF Is Required for Fab-8 Enhancer Blocking Activity in S2 Cells
Creators: name: Rogers, Steve
name: Magnuson, Terry
name: Ciavatta, Dominic
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: CTCF is a conserved transcriptional regulator with binding sites in DNA insulators identified in vertebrates and invertebrates. The Drosophila Abdominal-B locus contains CTCF binding sites in the Fab-8 DNA insulator. Previous reports have shown that Fab-8 has enhancer blocking activity in Drosophila transgenic assays. We now confirm the enhancer blocking capability of the Fab-8 insulator in stably transfected Drosophila S2 cells and show this activity depends on the Fab-8 CTCF binding sites. Furthermore, knockdown of Drosophila CTCF by RNAi in our stable cell lines demonstrates that CTCF itself is critical for Fab-8 enhancer blocking.
title: Congestive hepatopathy, Doppler ultrasonographic changes every radiologist should know
Creators: name: Kimura, Yukiyoshi
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Liver
subject: Veins / Vena cava
subject: Abdomen
subject: Ultrasound-Spectral Doppler
subject: Ultrasound-Colour Doppler
subject: Ultrasound
subject: Diagnostic procedure
subject: Cirrhosis
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: • Present the approach used to interpret physiological hepatic spectral Doppler ultrasounds, as well as the pathological findings seen throughout the natural history of congestive hepatopathy. • Familiarize yourself with physiological...
5G-IANA - D1.4 Data Management Plan
Creators: name: Andrea Suarez
name: Edoardo Bonetto
name: Eirini Liotou
name: Francesca Moscatelli
name: Markus Wimmer
Publisher: name: Zenodo
Year: 2023
Subjects: Data, management, deliverable, 5G-IANA

description: This deliverable, D1.4 - Data Management Plan (DMP), aims at providing a detailed description of the data to be generated during the implementation of the project, whether and how it will be exploited or made accessible for verification and re-use, and how it will be curated and preserved. Thus, the objective is to provide guidelines that will define simple and practical pointers during the implementation and validation stages of the project, support compliance with underlying legal obligations, and promote the adoption of best data management practices.
Generalized Dyck tilings
Creators: name: Josuat-Vergès, Matthieu
name: Kim, Jang Soo
Publisher: name: arXiv
Year: 2014
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: Recently, Kenyon and Wilson introduced Dyck tilings, which are certain tilings of the region between two Dyck paths. The enumeration of Dyck tilings is related with hook formulas for forests and the combinatorics of Hermite polynomials. The first goal of this work is to give an alternative point of view on Dyck tilings by making use of the weak order and the Bruhat order on permutations. Then we introduce two natural generalizations: $k$-Dyck tilings and symmetric Dyck tilings. We are led to consider Stirling permutations, and define an analog of the Bruhat order on them. We show that certain families of $k$-Dyck tilings are in bijection with intervals in this order. We also enumerate symmetric Dyck tilings.
description: 15 pages, 17 figures
Heating and Ionization of the Primordial Intergalactic Medium by High Mass X-ray Binaries
Creators: name: Knevitt, Gillian
name: Wynn, Graham
name: Power, Chris
name: Bolton, James
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We investigate the influence of High Mass X-ray Binaries on their high redshift environments. Using a one-dimensional radiative transfer code, we predict the ionization and temperature profiles surrounding a coeval stellar population, composed of main sequence stars and HMXBs, at various times after its formation. We consider both uniform density surroundings, and a cluster embedded in a 10^8 solar mass NFW halo. HMXBs in a constant density environment produce negligible enhanced ionization because of their high-energy SEDs and short lifetimes. In this case, HMXBs only marginally contribute to the local heating rate. For NFW profiles, radiation from main sequence stars cannot prevent the initially ionized volume from recombining since it is unable to penetrate the high density galactic core. However, HMXB photons stall recombinations behind the front, keeping it partially ionized for longer. The increased electron density in these partially ionized regions promotes further cooling, resulting in lower IGM temperatures. In the context of this starburst model, we have shown that HMXBs do not make a major contribution to reionization or IGM heating. However, X-ray escape fractions are high in both density profile cases. Continuous star formation may result in the build up of X-rays over time, reducing the ionization timescale and potentially leading to low level ionization of the distant IGM.
description: 16 pages, 11 figures, accepted for publication in MNRAS
5G-IANA - D1.4 Data Management Plan
Creators: name: Suarez, Andrea
Publisher: name: Zenodo
Year: 2022
Subjects: Data, management, deliverable, 5G-IANA

description: [Deliverable pending final approval by the EC] This deliverable, D1.4 - Data Management Plan (DMP), aims at providing a detailed description of the data to be generated during the implementation of the project, whether and how it will be exploited or made accessible for verification and re-use, and how it will be curated and preserved. Thus, the objective is to provide guidelines that will define simple and practical pointers during the implementation and validation stages of the project, support compliance with underlying legal obligations, and promote the adoption of best data management practices.
Forretningsreferencemodel
Creators: Digitaliseringsstyrelsen
Publisher: name: Rigsarkivet
Year: 2025

description: Forretningsreferencemodellen (FORM) er et katalog over det offentliges opgaver, både i forhold til borgere og virksomheder, vedrørende internationale relationer og samfundsforhold, og endelig vedrørende de interne administrative opgaver, der fungerer som et analyse- og struktureringsredskab, der skaber overblik og et fælles sprog på tværs af den offentlige sektor.
title: Thoracic and extra-thoracic tuberculosis (TB) on 18F- fluoro-deoxy-glucose positron emission tomography (18F-FDG PET): the great imitator.
Creators: name: McGill, Maria
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Nuclear medicine
subject: PET
subject: PET-CT
subject: Diagnostic procedure
subject: Infection
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: 1) Review of thoracic and extra-thoracic presentations of tuberculosis (TB) on 18 F- fluoro-deoxy-glucose positron emission tomography ( 18 F-FDG PET). 2) Reinforce importance of considering TB as a differential diagnosis in patients undergoing...
title: Can pediatric radiography be practiced appropriately in non-dedicated pediatric radiology unit? Case study: A radiology department at a Norwegian local hospital
Creators: name: Rusandu, Albertina
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Safety
subject: Health policy and practice
subject: CT
subject: Digital radiography
subject: Radiographers
subject: Paediatric
subject: Management
subject: Socio-economic issues
subject: Patterns of Care

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Norway’s population density, demographic scatter and distinct topography presents unique challenges for the medical system. One of them is the quite common practice at some small local hospitals to perform radiological examinations in children in...
Udsathed for vold og andre former for kriminalitet. Offerundersøgelserne 2023
Creators: Justitsministeriets Forskningsenhed
Publisher: name: Rigsarkivet
Year: 2025

description: Formålet med offerundersøgelsen er at belyse befolknings udsathed for kriminalitet anmeldelses tilbøjelighed samt bekymring for personligt at blive udsat for kriminalitet og for kriminalitet i samfundet.
5G-IANA - D1.4 Data Management Plan
Creators: name: Suarez, Andrea
name: Bonetto, Edoardo
name: Liotou, Eirini
name: Moscatelli, Francesca
name: Wimmer, Markus
Publisher: name: Zenodo
Year: 2022
Subjects: Data, management, deliverable, 5G-IANA

description: [Deliverable pending final approval by the EC] This deliverable, D1.4 - Data Management Plan (DMP), aims at providing a detailed description of the data to be generated during the implementation of the project, whether and how it will be exploited or made accessible for verification and re-use, and how it will be curated and preserved. Thus, the objective is to provide guidelines that will define simple and practical pointers during the implementation and validation stages of the project, support compliance with underlying legal obligations, and promote the adoption of best data management practices.
Molecular and Functional Mapping of EED Motifs Required for PRC2-Dependent Histone Methylation
Creators: name: Montgomery, Stephanie A.
name: Montgomery, Nathan D.
name: Yee, Della
name: Magnuson, Terry
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Polycomb Group (PcG) proteins represent a conserved family of developmental regulators that mediate heritable transcriptional silencing by modifying chromatin states. One PcG complex, the PRC2 complex, is composed of several proteins, including the histone H3 lysine 27 (H3K27) methyltransferase EZH2 and the WD-repeat protein EED. Histone H3K27 can be mono- (H3K27me1), di- (H3K27me2), or trimethylated (H3K27me3). However, it remains unclear what regulates the number of methyl groups added to H3K27 in a particular nucleosome. In mammalian cells, EED is present as four distinct isoforms, which are believed to be produced by utilizing four distinct, in-frame translation start sites in a common Eed mRNA. A mutation that disables all four EED isoforms produces defects in H3K27 methylation.1 To assess the roles of individual EED isoforms in H3K27 methylation, we first characterized three of the four EED isoform start sites and then demonstrated that individual isoforms are not necessary for H3K27me1, H3K27me2, or H3K27me3. Instead, we show that the core WD-40 motifs and the histone binding region of EED alone are sufficient for the generation of all three marks, demonstrating that EED isoforms do not control the number of methyl groups added to H3K27.
title: РАЗВИТИЕ ИНСТРУМЕНТОВ УПРАВЛЕНИЯ ЗАТРАТАМИ ПОЛНОГО ЖИЗНЕННОГО ЦИКЛА ВЫСОКОТЕХНОЛОГИЧНОЙ ПРОМЫШЛЕННОЙ ПРОДУКЦИИ В УСЛОВИЯХ ЦИФРОВИЗАЦИИ
Creators: name: Голубев, Сергей
name: Веселовский, Михаил
name: Хорошавина, Наталья
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: Актуальность темы исследования обусловлена необходимостью развития механизмов управления затратами на этапах жизненного цикла высокотехнологичной продукции при внедрении цифровых технологий. Глобальная цифровизация затронула все сферы деятельности и отрасли экономики. Особое значение цифровизация приобрела в области высокотехнологичной промышленности. Управление жизненным циклом высокотехнологичной продукции в условиях цифровизации ставит новые вызовы. В первую очередь, связанные со снижением уровня совокупных затрат на всех этапах жизненного цикла высокотехнологичной промышленной продукции. Сегодня цифровые технологии открывают новые возможности для сбора, хранения и анализа данных о затратах производственного процесса. В связи с этим в условиях цифровизации особую актуальность приобретают вопросы управления затратами полного жизненного цикла высокотехнологичной продукции.
End-use/stakeholder requirements
Creators: name: Coroiu, Mihaela
name: Marin, Sergiu
name: Trujillo, Laura
name: Venegas, Eliseo
name: Dounia, Theoni
name: Vryonis, Nikos
name: Sakkas, Christos
name: Vergi, Eugenia
name: Efremidis, Sofoklis
name: Ntafloukas, Kostas
name: Stelliou, Konstantina
name: Sanchez, Karina
Publisher: name: Zenodo
Year: 2022
Subjects: cybersecurity
healthcare

description: Today’s organizations need to be cyber resilient, equipped with advanced cybersecurity capabilities for ensuring quick recovery in the face of crippling modern cyber threats. The EU-funded SECANT project will develop an innovative cyber security risk assessment platform to enhance these capabilities to tackle cascading cyber threats and vulnerabilities, increasing privacy, data protection and accountability across the entire interconnected ICT ecosystem. During the implementation of WP2, SECANT project’s consortium partners performed a user and stakeholder requirements analysis in order to obtain relevant feedback and information to design and refine the use cases scenarios to be developed and tested and for the SECANT Platform‘s architecture design.
 The WP2 implementation started with Task 2.1- User requirements specification, with direct involvement of following partners: POLARIS; NTTDES, KI, CERTH, 8BELLS, UBI, AXON, THALES, CLS, SIMAVI, IANUS, DNSC, BI2S, INF, TICSALUT, ADR, SLC. The period of Task 2.1 implementation was M01-M08.
 Under Task 2.1 the activities focused to collect the requirements of the different SECANT stakeholders (e.g. clients, professionals) obtained through standard techniques (online questionnaires and focus groups). The list of these requirements regarding the SECANT platform functionalities will be used to validate the SECANT platform in WP6 and guide the development of the different modules during the project. Then, KPIs will be devised (based on these requirements) to create a set of measurable goals for the SECANT platform validation. This deliverable includes the results of task 2.1, reporting on the feedback received during consultations with the end-users/stakeholders. The list of the end-user/stakeholder requirements identified is included in the present document (D2.1). For each requirement, it has been presented a brief description about its role within the SECANT Platform and based on the feedback data collected during research process, it has been calculated the score as the average value of scores granted by the online questionnaire respondents. Respondents were invited to give a score from 1 to 5, where 5 is the maximum. The requirements that scored less than 3 are considered NICE TO HAVE; those with a score between 3 and 4 are considered SHOULD HAVE, and those with a score above 4 are considered MUST HAVE requirements.
 The results presented in this Deliverable 2.1 will be used for refining the technical requirements during Task 2.2 and later during project implementation to validate SECANT platform functionalities.
The Role of Nucleobase Interactions in RNA Structure and Dynamics
Creators: name: Bottaro, Sandro
name: Di Palma, Francesco
name: Bussi, Giovanni
Publisher: name: arXiv
Year: 2014
Subjects: subject: Biomolecules (q-bio.BM)
subject: Biological Physics (physics.bio-ph)
subject: Chemical Physics (physics.chem-ph)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: The intricate network of interactions observed in RNA three-dimensional structures is often described in terms of a multitude of geometrical properties, including helical parameters, base pairing/stacking, hydrogen bonding and backbone conformation. We show that a simple molecular representation consisting in one oriented bead per nucleotide can account for the fundamental structural properties of RNA. In this framework, canonical Watson-Crick, non-Watson-Crick base-pairing and base-stacking interactions can be unambiguously identified within a well-defined interaction shell. We validate this representation by performing two independent, complementary tests. First, we use it to construct a sequence-independent, knowledge-based scoring function for RNA structural prediction, which compares favorably to fully atomistic, state-of-the-art techniques. Second, we define a metric to measure deviation between RNA structures that directly reports on the differences in the base-base interaction network. The effectiveness of this metric is tested with respect to the ability to discriminate between structurally and kinetically distant RNA conformations, performing better compared to standard techniques. Taken together, our results suggest that this minimalist, nucleobase-centric representation captures the main interactions that are relevant for describing RNA structure and dynamics.
description: Accepted for publication on Nucleic Acids Research
The Magellan Uniform Survey of Damped Lyman alpha Systems II: Paucity of Strong Molecular Hydrogen Absorption
Creators: name: Jorgenson, Regina A.
name: Murphy, Michael T.
name: Thompson, Rodger
name: Carswell, Robert F.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present the first large, blind and uniformly selected survey for molecular hydrogen (H_2) in damped Lyman alpha systems (DLAs) with moderate-to-high resolution spectra. 86 DLAs were searched for absorption in the many Lyman and Werner H_2 transitions, with approximately 79% completeness for H_2 column densities above N(H_2)=10^17.5 cm^-2 for an assumed Doppler broadening parameter b=2 km s^-1. Only a single strong H_2 absorber was found -- a system detected previously in VLT/UVES spectra. Given our distribution of N(H_2) upper limits, this ~1% detection rate is smaller than expected from previous surveys at 99.8% confidence. Assuming the N(H_2) distribution shape from previous surveys, our detection rate implies a covering factor of ~1% for N(H_2) >= 10^17.5 cm^-2 gas in DLAs (<6% at 95% confidence). We obtained new Magellan/MagE spectra for 53 DLAs; 8 km s^-1 -resolution spectra were available for 27 DLAs. MagE's moderate resolution (~71 km s^-1) yields weaker N(H_2) upper limits and makes them dependent on the assumed Doppler parameter. For example, half the (relevant) previous H_2 detections have N(H_2) >= 10^18.1 cm^-2, a factor of just 3 higher than our median upper limit. Nevertheless, several tests suggest our upper limits are accurate, and they would need to be increased by 1.8 dex to bring our detection rate within 95% confidence of previous surveys.
description: 21 pages, 20 figures, Accepted by MNRAS
Molecular Dynamic Simulations of Cisplatin- and Oxaliplatin-d(GG) Intrastand Cross-links Reveal Differences in their Conformational Dynamics
Creators: name: Temple, Brenda
name: Chaney, Stephen G.
name: Sharma, Shantanu
name: Bhattacharyya, Debadeep
name: Gong, Peng
name: Dokholyan, Nikolay V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Mismatch repair proteins, DNA damage-recognition proteins and translesion DNA polymerases discriminate between Pt-GG adducts containing cis-diammine ligands (formed by cisplatin (CP) and carboplatin) and trans-RR-diaminocyclohexane ligands (formed by oxaliplatin (OX)) and this discrimination is thought to be important in determining differences in the efficacy, toxicity and mutagenicity of these platinum anticancer agents. We have postulated that these proteins recognize differences in conformation and/or conformational dynamics of the DNA containing the adducts. We have previously determined the NMR solution structure of OX-DNA, CP-DNA and undamaged duplex DNA in the 5'-d(CCTCAGGCCTCC)-3' sequence context and have shown the existence of several conformational differences in the vicinity of the Pt-GG adduct. In this study we have used molecular dynamics simulations to explore differences in the conformational dynamics between OX-DNA, CP-DNA and undamaged DNA in the same sequence context. Twenty-five 10 ns unrestrained fully solvated molecular dynamics simulations were performed starting from two different DNA conformations using AMBER v8.0. All twenty-five simulations reached equilibrium within 4 ns, were independent of the starting structure and were in close agreement with previous crystal and NMR structures. Our data show that the cis-diammine (CP) ligand preferentially forms hydrogen bonds on the 5' side of the Pt-GG adduct, while the trans-RR-diaminocyclohexane (OX) ligand preferentially forms hydrogen bonds on the 3' side of the adduct. In addition, our data show that these differences in hydrogen bond formation are strongly correlated with differences in conformational dynamics, specifically the fraction of time spent in different DNA conformations in the vicinity of the adduct, for CP- and OX-DNA adducts. We postulate that differential recognition of CP- and OX-GG adducts by mismatch repair proteins, DNA damage-recognition proteins and DNA polymerases may be due, in part, to differences in the fraction of time that the adducts spend in a conformation favorable for protein binding.