cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: LmeA, a Conserved Cell-Envelope Protein in Mycobacteria, is Important for Antibiotic Resistance and Cell Envelope Permeability
Creators: name: Osman, Sarah Hassan
Publisher: name: University of Massachusetts Amherst
Year: 2020

description: The cell envelope of mycobacteria is critical for the survival and virulence of pathogenic species during infection, and its biosynthesis has been a proven drug target. Therefore, finding new targets in the biosynthetic pathway of cell envelope components is of great interest. Mycobacterium smegmatis is a model organism for the study of the devastating pathogen Mycobacterium tuberculosis. Previously, lipomannan elongation factor A (LmeA) has been identified as a cell envelope protein that is critical for the control of mannan chain length of lipomannan (LM) and lipoarabinomannan (LAM), lipoglycan components of the cell envelope. The deletion mutant, ∆lmeA, accumulates abnormal LM/LAM with fewer mannan residues. To understand the importance of this protein, the antibiotic sensitivity of ∆lmeA was tested using a resazurin-based viability assay. We found that the lmeA deletion leads to increased sensitivities to antibiotics such as vancomycin and erythromycin, and lmeA overexpression leads to increased antibiotic resistance. To directly test if the increased antibiotic sensitivity is due to the defective permeability barrier, we used an ethidium bromide uptake assay and found that ∆lmeA is more efficient in taking up ethidium bromide in the cell. We have also found that LmeA is important for protein stabilization under stress conditions. MptA is an α1,6-mannosyltransferase involved in elongation of LM and LAM mannan chain. During stress conditions in the ΔlmeA mutant, levels of MptA decrease significantly relative to wild-type. This also results in delayed doubling time after stress, a phenotype not seen in this mutant under normal growth conditions. In addition, the ΔlmeA mutant has differential protein expression during stress conditions relative to ΔlmeA in log phase, or to wild-type in either condition. To help elucidate the role of LmeA at the molecular level, binding behavior of this protein to membrane fractions was determined. In a subcellular fractionation analysis, LmeA localizes to fractions containing plasma membrane, which is tightly bound to cell wall layers. To test the binding of LmeA to membrane further, LmeA was heterologously expressed in Escherichia coli, purified, and mixed M. smegmatis cell lysate. LmeA localized to intracellular domain fractions (IMD), indicating that LmeA is capable of localizing to fractions containing only plasma membrane. Consistent with this finding, LmeA is capable of binding to spheroplasts in both an ELISA setting as well as in a sucrose gradient fractionation setting. It has also been determined that ΔlmeA has a defective capsular layer with a unique phenotype relative to other strains. We have concluded that LmeA is important for antibiotic resistance, cell envelope permeability, capsule formation, stress response, and have also determined its binding properties.
Additional file 11 of Vickermania gen. nov., trypanosomatids that use two joined flagella to resist midgut peristaltic flow within the fly host
Creators: name: Kostygov, Alexei Y.
name: Frolov, Alexander O.
name: Malysheva, Marina N.
name: Ganyukova, Anna I.
name: Chistyakova, Lyudmila V.
name: Tashyreva, Daria
name: Tesařová, Martina
name: Spodareva, Viktoria V.
name: Režnarová, Jana
name: Macedo, Diego H.
name: Butenko, Anzhelika
name: D’Avila-Levy, Claudia M.
name: Lukeš, Julius
name: Yurchenko, Vyacheslav
Publisher: name: figshare
Year: 2020
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Cancer
subject: Computational Biology

description: Additional file 11: Table S4. Sequences of 18S rRNA gene used in this work.
title: An das deutsche Volk. Deutsche! Eure in Frankfurt versammelten Vertreter haben mich zum deutschen Reichsverweser erwählt. ...; [1848]
title: Frankfurt am Main, den 15. Juli 1848
titleType: Subtitle
Creators: name: Johann Österreich, Erzherzog
name: Schmerling, Anton ¬von
name: Peucker, Eduard ¬von
name: Heckscher, Johann Gustav Wilhelm
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2018

description: Kopftitel
Dangerous tales: Dominant narratives on the Congo and their unintended consequences
Creators: name: Autesserre, Severine
Publisher: name: Columbia University
Year: 2012
Subjects: subject: Violence
subject: Human rights--International cooperation
subject: Human rights
subject: Political science
subject: FOS: Political science
subject: International relations
subject: History

description: Explanations for the persistence of violence in the eastern part of the Democratic Republic of Congo blame the incendiary actions of domestic and regional leaders, as well as the inefficacy of international peace-building efforts. Based on several years of ethnographic research, this article adds another piece to the puzzle, emphasizing the perverse consequences of well-meaning international efforts. I argue that three narratives dominate the public discourse on Congo and eclipse the numerous alternative framings of the situation. These narratives focus on a primary cause of violence, illegal exploitation of mineral resources; a main consequence, sexual abuse of women and girls; and a central solution, extending state authority. I elucidate why simple narratives are necessary for policy makers, journalists, advocacy groups, and practitioners on the ground, especially those involved in the Congo. I then consider each narrative in turn and explain how they achieved prominence:! they provided straightforward explanations for the violence, suggested feasible solutions to it, and resonated with foreign audiences. I demonstrate that the focus on these narratives and on the solutions they recommended has led to results that clash with their intended purposes, notably an increase in human rights violations.
Evolution of $1/f$ Flux Noise in Superconducting Qubits with Weak Magnetic Fields
Creators: name: Rower, David A.
name: Ateshian, Lamia
name: Li, Lauren H.
name: Hays, Max
name: Bluvstein, Dolev
name: Ding, Leon
name: Kannan, Bharath
name: Almanakly, Aziza
name: Braumüller, Jochen
name: Kim, David K.
name: Melville, Alexander
name: Niedzielski, Bethany M.
name: Schwartz, Mollie E.
name: Yoder, Jonilyn L.
name: Orlando, Terry P.
name: Wang, Joel I-Jan
name: Gustavsson, Simon
name: Grover, Jeffrey A.
name: Serniak, Kyle
name: Comin, Riccardo
name: Oliver, William D.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The microscopic origin of $1/f$ magnetic flux noise in superconducting circuits has remained an open question for several decades despite extensive experimental and theoretical investigation. Recent progress in superconducting devices for quantum information has highlighted the need to mitigate sources of qubit decoherence, driving a renewed interest in understanding the underlying noise mechanism(s). Though a consensus has emerged attributing flux noise to surface spins, their identity and interaction mechanisms remain unclear, prompting further study. Here we apply weak in-plane magnetic fields to a capacitively-shunted flux qubit (where the Zeeman splitting of surface spins lies below the device temperature) and study the flux-noise-limited qubit dephasing, revealing previously unexplored trends that may shed light on the dynamics behind the emergent $1/f$ noise. Notably, we observe an enhancement (suppression) of the spin-echo (Ramsey) pure dephasing time in fields up to $B=100~\text{G}$. With direct noise spectroscopy, we further observe a transition from a $1/f$ to approximately Lorentzian frequency dependence below 10 Hz and a reduction of the noise above 1 MHz with increasing magnetic field. We suggest that these trends are qualitatively consistent with an increase of spin cluster sizes with magnetic field. These results should help to inform a complete microscopic theory of $1/f$ flux noise in superconducting circuits.
The Medical Home and Care Coordination in Disaster Recovery: Hypothesis for Interventions and Research
Creators: name: Kanter, Robert K.
name: Abramson, David M.
name: Redlener, Irwin E.
name: Gracy, Delaney
Publisher: name: Columbia University
Year: 2015
Subjects: Public health
Mental health
Disaster relief
Health services administration
Medical care

description: In postdisaster settings, health care providers encounter secondary surges of unmet primary care and mental health needs that evolve throughout disaster recovery phases. Whatever a community’s predisaster adequacy of health care, postdisaster gaps are similar to those of any underserved region. We hypothesize that existing practice and evidence supporting medical homes and care coordination in primary care for the underserved provide a favorable model for improving health in disrupted communities. Elements of medical home services can be offered by local or temporary providers from outside the region, working out of mobile clinics early in disaster recovery. As repairs and reconstruction proceed, local services are restored over weeks or years. Throughout recovery, major tasks include identifying high-risk patients relative to the disaster and underlying health conditions, assisting displaced families as they transition through housing locations, and tracking their evolving access to health care and community services as they are restored. Postdisaster sources of financial assistance for the disaster-exposed population are often temporary and evolving, requiring up-to-date information to cover costs of care until stable services and insurance coverage are restored. Evidence to support disaster recovery health care improvement will require research funding and metrics on structures, processes, and outcomes of the disaster recovery medical home and care coordination, based on adaptation of standard validated methods to crisis environments.
Additional file 3 of Understanding breastfeeding behaviours: a cross-sectional analysis of associated factors in Ireland, the United Kingdom and Australia
Creators: name: Gallegos, Danielle
name: Parkinson, Joy
name: Sinead Duane
name: Domegan, Christine
name: Jansen, Elena
name: Russell-Bennett, Rebekah
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Cancer

description: Additional file 3. Example Facebook advertisement.
An unusual association in a patient with COVID-19-related ARDS and bilateral pleural effusion
Creators: name: Cipolla, Antonio
name: Faiello, Antonio
name: Ielo, Giuseppe
name: Morana, Giorgio
name: Lo Bello, Federica
name: Proietto, Alfio
name: Vanchieri, Carlo
name: Caramori, Gaetano
Publisher: name: Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche
Year: 2023
Subjects: acute respiratory failure, sarcoidosis, pleural effusion, pneumonia

description: We present the case of a 76-year-old female, previously diagnosed with pulmonary sarcoidosis, that was admitted to our Unit of Pulmonology for acute hypoxemic respiratory failure secondary to COVID-19-related acute respiratory distress syndrome (ARDS) and with bilateral pleural effusions. Despite the therapy the patient’s conditions gradually deteriorated during the hospital stay with progressive hypoxemia and the patient died 36 days after the admission
description: Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche, Vol 111, No 1 (2023)
Measurement of the 5D Level Polarizabilty in Laser Cooled Rb atoms
Creators: name: Snigirev, S.
name: Golovizin, A.
name: Tregubov, D.
name: Pyatchenkov, S.
name: Sukachev, D.
name: Akimov, A.
name: Sorokin, V.
name: Kolachevsky, N.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Quantum Physics (quant-ph)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We report on accurate measurements of the scalar and tensor polarizabilities of the 5D fine structure levels 5D3/2 and 5D5/2 in Rb. The measured values show reasonable correspondence to previously published theoretical predictions, but are more accurate. We implemented laser excitation of the 5D level in a laser cooled cloud of optically polarized Rb-87 atoms placed in a constant electric field.
description: 8 pages, 9 figures
A case of a shocking rhythm
Creators: name: Galletta, Francesca
name: Gambadauro, Antonella
name: Manti, Sara
name: Caime, Flavia
name: Fusco, Monica
name: Allera, Simona
name: Iannelli, Mauro
name: Barbuscia, Letteria
name: Gitto, Eloisa
Publisher: name: Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche
Year: 2023
Subjects: newborn;supraventricular tachycardia; cardiogenic shock

description: We report a case of a 40-day-old patient admitted to the neonatal and paediatric intensive care unit for severe cardiovascular failure with an initial sinus rhythm. The first diagnostic hypothesis was septic shock, thus antibiotics, fluid resuscitation, inotropic drugs and ventilatory supportwere immediately started. After achieving haemodynamic stability, a new cardiovascular failure occurred with supraventricular tachycardia (SVT), making diagnosis of cardiogenic shock. Cardiogenic shock should be considered, although it is a rare cause of shock in children. SVT may be a cause of cardiogenic shock, therefore it should be diagnosed whit the aid of a cardiorespiratory monitor, which represents a useful device in the differential diagnosis of the various types of shock.
description: Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche, Vol 111, No 1 (2023)
Electromagnetic coupling and transport in a topological insulator-graphene hetero-structure
Creators: name: Bonilla, Daniel A.
name: Castaño-Yepes, Jorge David
name: Martín-Ruiz, A.
name: Muñoz, Enrique
Publisher: name: arXiv
Year: 2023
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The electromagnetic coupling between hetero-structures made of different materials is of great interest, both from the perspective of discovering new phenomena, as well as for its potential applications in novel devices. In this work, we study the electromagnetic coupling of a hetero-structure made of a topological insulator (TI) slab and a single graphene layer, where the later presents a diluted concentration of ionized impurities. We explore the topological effects of the magneto-electric polarizability (MEP) of the TI, as well as its relative dielectric permittivity on the electrical conductivity in graphene at low but finite temperatures.
description: 21 pages, 12 figures
Single-tape and Multi-tape Turing machines through the lens of the Grossone methodology
Creators: name: Sergeyev, Yaroslav D.
name: Garro, Alfredo
Publisher: name: arXiv
Year: 2013
Subjects: subject: Formal Languages and Automata Theory (cs.FL)
subject: FOS: Computer and information sciences
subject: F.1.1; F.4.1
subject: 68Q05, 03D10

description: The paper investigates how the mathematical languages used to describe and to observe automatic computations influence the accuracy of the obtained results. In particular, we focus our attention on Single and Multi-tape Turing machines which are described and observed through the lens of a new mathematical language which is strongly based on three methodological ideas borrowed from Physics and applied to Mathematics, namely: the distinction between the object (we speak here about a mathematical object) of an observation and the instrument used for this observation; interrelations holding between the object and the tool used for the observation; the accuracy of the observation determined by the tool. Results of the observation executed by the traditional and new languages are compared and discussed.
description: 21 pages. arXiv admin note: substantial text overlap with arXiv:1203.3298
Additional file 1 of COSMIN Risk of Bias tool to assess the quality of studies on reliability or measurement error of outcome measurement instruments: a Delphi study
Creators: name: Mokkink, L. B.
name: M. Boers
name: C. P. M. Van Der Vleuten
name: L. M. Bouter
name: J. Alonso
name: D. L. Patrick
name: H. C. W. De Vet
name: C. B. Terwee
Publisher: name: figshare
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy

description: Additional file 1: Appendix 1. Search strategies for finding potential panelists. Appendix 2. References for systematic reviews on measurement instruments from the COSMIN database of systematic reviews of outcome measurement instruments. Appendix 3. Components of outcome measurement instruments that do not involve biological sampling. Appendix 4. Components of outcome measurement instruments that involve biological sampling. Appendix 5. Formulation for element 4 of a comprehensive research question as proposed in round 1 and 2.
Clinical score for surgical treatment of acute scrotum in pediatric age
Creators: name: Bonfiglio, Roberta
name: Cassaro, Fabiola
name: Cambiaso, Chiara
name: D'Antoni, Santi
name: Montalto, Angela Simona
name: Arena, Salvatore
name: Romeo, Carmelo
name: Impellizzeri, Pietro
Publisher: name: Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche
Year: 2023
Subjects: Acute scrotum, Testicular torsion, TWIST score, Doppler ultrasound, Children, Pediatric patients

description: Acute scrotum is a set of signs and symptoms that should lead the patient to go to a first aid center. There are different causes of these signs and symptoms, but testicular torsion is identified as the main ones and can be suspected thanks to a careful history, physical examination and testicular ultrasound. It is important to quickly differentiate the various conditions associated with acute scrotum in order to optimize surgery times and preserve testicular vitality. Often the radiological study is essential to identify the causes of acute scrotum, in particular the testicular Doppler ultrasound is sensitive and specific for testicular torsion, infact it is considered the gold standard for diagnosis. However, the radiological study can delay surgical treatment and reduce testicular vitality. So TWIST score was proposed. It is based on the identification of signs and symptoms that can lead at clinical diagnosis of testicular torsion. Our narrative of literature review analyzes TWIST score validity and shows the utility of an adequate clinical examination obtaining a diagnosis of torsion cord, reducing the costs and the time of surgical treatment resulting in a higher likelihood of preserving testicular vitality
description: Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche, Vol 111, No 1 (2023)
Detection prospects of singlet fermionic dark matter
Creators: name: Esch, Sonja
name: Klasen, Michael
name: Yaguna, Carlos E.
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: A singlet fermion which interacts only with a new singlet scalar provides a viable and minimal scenario that can explain the dark matter. The singlet fermion is the dark matter particle whereas the new scalar mixes with the Higgs boson providing a link between the dark matter sector and the Standard Model. In this paper, we present an updated analysis of this model focused on its detection prospects. Both, the parity-conserving case and the most general case are considered. First, the full parameter space of the model is analyzed, and the regions compatible with the dark matter constraint are obtained and characterized. Then, the implications of current and future direct detection experiments are taken into account. Specifically, we determine the regions of the multidimensional parameter space that are currently excluded and those that are going to be probed by next generation experiments. Finally, indirect detection prospects are discussed and the expected signal at neutrino telescopes is calculated.
description: 24 pages, many figures. v2: minor modifications to text and figures. Main results unchanged
Additional file 2 of Understanding breastfeeding behaviours: a cross-sectional analysis of associated factors in Ireland, the United Kingdom and Australia
Creators: name: Gallegos, Danielle
name: Parkinson, Joy
name: Sinead Duane
name: Domegan, Christine
name: Jansen, Elena
name: Russell-Bennett, Rebekah
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Cancer

description: Additional file 2. Checklist for Reporting Results of Internet E-Surveys (CHERRIES).
Sharing Low Frequency Radio Emissions in the Virtual Observatory: Application for JUNO-Ground-Radio Observations Support.
Creators: name: Cecconi, Baptiste
name: Savane, Renaud
name: Le Sidaner, Pierre
name: Hess, Sébastien L G
name: Erard, Stéphane
name: Zarka, Philippe
name: Lamy, Laurent
name: Coffre, Andrée
name: Denis, laurent
name: André, Nicolas
name: Génot, Vincent
name: Girard, Julien N G
name: Grießmeier, Jean-Mathias
name: Clarke, Tracy
name: Anderson, Marin
name: Ebert, Robert
name: Higgins, Charles
name: Sky, Jim
name: Thieman, James
name: Typinski, Dave
name: Hobara, Yasuhide
name: Imai, Kazumasa
name: Kurth, William S
name: Imai, Masafumi
name: Kasaba, Yasumasa
name: Kumamoto, Atsushi
name: Tsuchiya, Fuminori
name: Misawa, Hiroaki
name: Konovalenko, Alexander
name: Nakajo, Tomoyuki
name: Orton, Glenn S
name: Ryabov, Vladimir
Publisher: name: Zenodo
Year: 2016
Subjects: Jupiter
Radio Astronomy
Virtual Observatory

description: In the frame of the preparation of the NASA/JUNO and ESA/JUICE (Jupiter Icy Moon Explorer) missions, and the development of a planetary sciences virtual observatory (VO), we are proposing a new set of tools directed to data providers as well as users, in order to ease data sharing and discovery. We will focus on ground based planetary radio observations (thus mainly Jupiter radio emissions), trying for instance to enhance the temporal coverage of jovian decametric emission. The data service we will be using is EPN-TAP, a planetary science data access protocol developed by Europlanet-VESPA (Virtual European Solar and Planetary Access). This protocol is derived from IVOA (International Virtual Observatory Alliance) standards. Data from all major decametric radio instruments will contribute: Nançay Decameter Array (France), LOFAR (France, Sweden, Poland), NenuFAR (France), URAN (Ukraine), LWA (USA), Iitate Radio Observatory (Japan), etc. Amateur radio data from the RadioJOVE project is also available. The attached figure shows data from those three providers. We will first introduce the VO tools and concepts of interest for the planetary radioastronomy community. We will then present the various data formats now used for such data services, as well as their associated metadata. We will finally show various prototypical tools that make use of this shared datasets.
Bedtime Stories
Creators: name: Mee, Charles L.
Publisher: name: Columbia University
Year: 1988
Subjects: Theater
Drama

description: Three pointless bedroom conversations, mundane and postcoital—about the man who grew so fat he choked himself to death with his own shirt collar, and looking for a good Hollywood agent and how, when Hinckley shot Reagan and the doctors stripped Reagan down in the emergency room they couldn't find his dick, and other random observations on the world today—interspersed with performance pieces, in a post-world of post-people. [4 actors, 3 performance pieces]
Another Person Is a Foreign Country
Creators: name: Mee, Charles L.
Publisher: name: Columbia University
Year: 1991
Subjects: Theater
Drama

description: A one and a half foot tall woman with the voice of an opera singer, a deaf man who signs, a transvestite, a pair of conjoined or identical twins, an immensely tall African American man-all take their places around a dinner table-and we join them for this most basic and universal of social activities, the breaking of bread. [8 actors, and, if possible, a chorus of fifteen people with Down Syndrome, a blind choir from the Lighthouse, and a rock band composed of musicians recently discharged from a mental hospital]
Role of autophagy in experimental varicocele: a Review
Creators: name: D'Antoni, Santi
name: Cassaro, Fabiola
name: Arena, Salvatore
name: Montalto, Angela Simona
name: Impellizzeri, Pietro
name: Ieni, Antonio
name: Romeo, Carmelo
Publisher: name: Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche
Year: 2023
Subjects: Varicocele; Autophagy; Male infertility

description: Varicocele (VC) is an abnormal venous dilatation and/or tortuosity of the pampiniform plexus in the scrotum (1). VC is one of the main factors causing male infertility and affects about 15% of all healthy male adults and about35% of patients with primary infertility (2), so it isparticularly important to clarify the pathogenetic mechanism in the course of male infertility. There is no single pathogenetic factor that alone justifies the adverse effects of varicocele on the testes. The pathogenesis of disease is complex and multifactorial, with several proposed mechanisms acting in synergy. Indeed, blood stasis negatively affects spermatogenesis by causing an increase in scrotal temperature (usually below 2°C at body temperature), hypoxic damage (stagnant hypoxia), a reflux of renal and adrenal catabolites, and last a modification of the testicular hormonal balance.
description: Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche, Vol 111, No 1 (2023)
Signatures of Non-universal Quantum Dynamics of Ultracold Chemical Reactions of Polar Alkali-dimer Molecules with Alkali-metal Atoms: Li($^2$S) +NaLi($a^3Σ^+$) $\to$ Na($^2$S) + Li$_2$($a^3Σ_u^+$)
Creators: name: Morita, Masato
name: Kendrick, Brian K.
name: Kłos, Jacek
name: Kotochigova, Svetlana
name: Brumer, Paul
name: Tscherbul, Timur V.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Ultracold chemical reactions of weakly bound triplet-state alkali-metal dimer molecules have recently attracted much experimental interest. We perform rigorous quantum scattering calculations with a new $ab\, initio$ potential energy surface to explore the chemical reaction of spin-polarized NaLi($a^3Σ^+$) and Li($^2$S) to form Li$_2$($a^3Σ_u^+$) and Na($^2$S). The reaction is exothermic, and proceeds readily at ultralow temperatures. Significantly, we observe strong sensitivity of the total reaction rate to small variations of the three-body part of the Li$_2$Na interaction at short range, which we attribute to a relatively small number of open Li$_2$($a^3Σ_u^+$) product channels populated in the reaction. This provides the first signature of highly non-universal dynamics seen in rigorous quantum reactive scattering calculations of an ultracold exothermic insertion reaction involving a polar alkali-dimer molecule, opening up the possibility of probing microscopic interactions in atom+molecule collision complexes via ultracold reactive scattering experiments.
description: 26 pages, 5 figures (Supporting information: 12 pages, 5 figures)
British Columbia Legislative Assembly sessional clipping book (1934-04)
Creators: name: :Unav
Publisher: name: University of Victoria Libraries
Year: 2022
Subjects: subject: Politics and government
valueUri: http://id.worldcat.org/fast/1919741
subject: Law
valueUri: http://id.worldcat.org/fast/993678
subject: FOS: Law
subject: British Columbia. Legislative Assembly
valueUri: http://id.worldcat.org/fast/600765

description: These Sessional Clippings books cover the period 1891 to 1972, and include newspaper accounts written by various legislative reporters who covered debates occurring in the British Columbia Legislative Assembly. Transcripts of debates of the Legislative Assembly (Hansard) were not published in B.C. until 1970; hence these "Sessional Clipping Books" augment the "Journals", the record of daily proceedings of the Legislative Assembly. Selected clippings from various newspapers including the Vancouver Sun, the Vancouver Province, the Colonist, and the Times newspapers, relating to the newspaper reports concerning activities of the Legislature. The original sessional clippings books comprise 351 ledger size print volumes, held at the Legislative Library in Victoria BC. The print volumes were microfilmed onto 26 reels in 1977 under a Tri University Libraries (TRIUL) project by Precision Micrographic Services (Vancouver, B.C.), with the permission of the Legislative Library, Victoria, British Columbia. This digital collection was created by scanning the 26 microfilm reels.
The Rules
Creators: name: Mee, Charles L.
Publisher: name: Columbia University
Year: 1996
Subjects: Theater
Drama

description: God knows what this piece is. Scenes and performance art pieces, and everyone ends up running for their lives. There's talk of the first Thanksgiving dinner, and some tips for wearing rubber, recollections of the good old days at the Mutaigha Club, and an agonized rationalization for selling one's own body—if that's what one has to sell—in an effort to arrive at a new set of conventions to live by, now that the old ones are gone. [6 actors]

Originally produced under the title "The Constitutional Convention: A Sequel."
Pseudo-Random Circuits from Clifford Plus T-Gates
Creators: name: Weinstein, Yaakov S.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We explore the implementation of pseudo-random single-qubit rotations and multi-qubit pseudo-random circuits constructed only from Clifford gates and the T-gate, a phase rotation of pi/4. Such a gate set would be appropriate for computations performed in a fault tolerant setting. For single-qubit rotations the distribution of parameters found for unitaries constructed from Clifford plus T quickly approaches that of random rotations and require significantly fewer gates than the construction of arbitrary single-qubit rotations. For Clifford plus T pseudo-random circuits we find an exponential convergence to a random matrix element distribution and a Gaussian convergence to the higher order moments of the matrix element distribution. These convergence rates are insensitive to the number of qubits.
description: 4 pages, 3 figures
Additional file 1 of Understanding breastfeeding behaviours: a cross-sectional analysis of associated factors in Ireland, the United Kingdom and Australia
Creators: name: Gallegos, Danielle
name: Parkinson, Joy
name: Sinead Duane
name: Domegan, Christine
name: Jansen, Elena
name: Russell-Bennett, Rebekah
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Cancer

description: Additional file 1. Irish Infant Feeding Survey.
Additional file 3 of Gestational arsenic exposure induces site-specific DNA hypomethylation in active retrotransposon subfamilies in offspring sperm in mice
Creators: name: Nohara, Keiko
name: Nakabayashi, Kazuhiko
name: Okamura, Kazuyuki
name: Suzuki, Takehiro
name: Shigekatsu Suzuki
name: Hata, Kenichiro
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3: Figure S4. Phylogenetic tree of ORF2 of L1MdA. ORF2 were annotated and ML tree was inferred using the same methods of Figure S3.
Combined Treatment with EGFR Inhibitors and Arsenite Upregulated Apoptosis in Human EGFR-positive Melanomas: A Role of Suppression of the PI3K-AKT Pathway
Creators: name: Ivanov, Vladimir N.
name: Hei, Tom K.
Publisher: name: Columbia University
Year: 2005
Subjects: Melanoma
Epidermal growth factor
Apoptosis
Cytology
Oncology

description: Epidermal growth factor receptor (EGFR) is expressed, albeit at low or intermediate levels, in human melanomas at the different stages of tumor progression. Coexpression of EGFR with its ligand TGFalpha indicates their role in paracrine and autocrine growth regulation of melanomas. As it was previously observed for several types of cancer, specific inhibitors of EGFR-mediated signaling may reduce antiapoptotic properties of cancer cells and sensitize them to cytotoxic drugs. We recently reported that arsenite, particularly in combination with inhibitors of the PI3K-AKT and mitogen-activated protein kinase (MAPK) kinase (MEK)-extracellular signal-regulated kinase (ERK) pathways, induces high levels of apoptosis in different melanomas. Since EGFR signaling operates via activation of the PI3K-AKT and MEK-ERK pathways, we suggested that the combination of arsenite and EGFR inhibitors might also effectively induce apoptosis in melanoma. Here, we demonstrate that a moderate concentration of arsenite (5-10 μM) indeed upregulates apoptosis induced by EGFR inhibitors in EGFR-positive melanomas. In contrast, induction of apoptosis in melanomas with negligible surface expression of EGFR or with defective EGFR signaling requires direct suppression of the PI3K-AKT and MAPK pathways by specific pharmacological inhibitors in the presence of arsenite. Under these conditions, metastatic melanoma cell lines undergo TNF-related apoptosis-inducing ligand (TRAIL)- and tumor necrosis factor alpha (TNFalpha)-mediated apoptosis. Taken together, these data provide additional approaches in sensitizing melanomas to the cytotoxic effects of specific inhibitors of survival pathways.
Additional file 2 of Gestational arsenic exposure induces site-specific DNA hypomethylation in active retrotransposon subfamilies in offspring sperm in mice
Creators: name: Nohara, Keiko
name: Nakabayashi, Kazuhiko
name: Okamura, Kazuyuki
name: Suzuki, Takehiro
name: Shigekatsu Suzuki
name: Hata, Kenichiro
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Figure S3. Phylogenetic tree of ORF1 of L1MdA. Bootstrap support (BP) is indicated above the lines and BP
Mechanism of Radiation-Induced Bystander Effect: Role of the Cyclooxygenase-2 Signaling Pathway
Creators: name: Ivanov, Vladimir N.
name: Hei, Tom K.
name: Zhou, Hongning
name: Gillespie, Joseph
name: Geard, Charles R.
name: Amundson, Sally A.
name: Brenner, David J.
name: Yu, Zengliang
name: Lieberman, Howard B.
Publisher: name: Columbia University
Year: 2005
Subjects: Cyclooxygenase 2
Radiotherapy
Cytology
Oncology

description: The radiation-induced bystander effect is defined as “the induction of biological effects in cells that are not directly traversed by a charged particle but are in close proximity to cells that are.” Although these bystander effects have been demonstrated with a variety of biological endpoints in both human and rodent cell lines (as well as in 3D tissue samples), the mechanism of the phenomenon is not known. Although gap junction communication and the presence of soluble mediator(s) are both known to play important roles in the bystander response, the precise signaling molecules have yet to be identified. By using the Columbia University charged particle beam in conjunction with a strip dish design, we show here that the cyclooxygenase-2 (COX-2, also known as prostaglandin endoperoxide synthase-2) signaling cascade plays an essential role in the bystander process. Treatment of bystander cells with NS-398, which suppresses COX-2 activity, significantly reduced the bystander effect. Because the critical event of the COX-2 signaling is the activation of the mitogen-activated protein kinase pathways, our finding that inhibition of the extracellular signal-related kinase phosphorylation suppressed bystander response further confirmed the important role of mitogen-activated protein kinase signaling cascade in the bystander process. These results provide evidence that the COX-2-related pathway, which is essential in mediating cellular inflammatory response, is the critical signaling link for the bystander phenomenon.
Additional file 2 of Patient involvement in quality improvement – a ‘tug of war’ or a dialogue in a learning process to improve healthcare?
Creators: name: Bergerum, Carolina
name: Engström, Agneta Kullén
name: Thor, Johan
name: Wolmesjö, Maria
Publisher: name: figshare
Year: 2020
Subjects: subject: Science Policy
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: Additional file 2. Interview guide. Healthcare professionals. English version.
Suppression of the Proinflammatory Response of Metastatic Melanoma Cells Increases TRAIL-Induced Apoptosis
Creators: name: Ivanov, Vladimir N.
name: Hei, Tom K.
name: Partridge, Michael A.
name: Huang, Sarah X. L.
Publisher: name: Columbia University
Year: 2011
Subjects: Melanoma
Apoptosis
Cytology
Oncology

description: Melanoma is the most lethal form of human skin cancer. However, only limited chemotherapy is currently available for the metastatic stage of the disease. Since chemotherapy, radiation and sodium arsenite treatment operate mainly through induction of the intrinsic mitochondrial pathway, a strongly decreased mitochondrial function in metastatic melanoma cells, could be responsible for low efficacy of the conventional therapy of melanoma. Another feature of metastatic melanoma cells is their proinflammatory phenotype, linked to endogenous expression of the inflammatory cytokines, such as TNFα IL6 and IL8, their receptors, and constitutive NF-κB- and STAT3-dependent gene expression, including cyclooxygenase-2 (PTGS2/COX2). In the present study, we treated melanoma cells with immunological (monoclonal antibody against TNFα or IL6), pharmacological (small molecular inhibitors of IKKβ–NF-κB and JAK2–STAT3) or genetic (specific RNAi for COX-2) agents that suppressed the inflammatory response in combination with induction of apoptosis via TRAIL. As a result of these combined treatments, exogenous TRAIL via interactions with TRAIL-R2/R1 strongly increased levels of apoptosis in resistant melanoma cells. The present study provides new understanding of the regulation of TRAIL-mediated apoptosis in melanoma and will serve as the foundation for the potential development of a novel approach for a therapy of resistant melanomas.
Opposite Roles of FAP-1 and Dynamin in the Regulation of Fas (CD95) Translocation to the Cell Surface and Susceptibility to Fas Ligand-mediated Apoptosis
Creators: name: Ivanov, Vladimir N.
name: Hei, Tom K.
name: Ronai, Ze'ev
Publisher: name: Columbia University
Year: 2006
Subjects: Melanoma
Apoptosis
Cytology
Oncology

description: Human melanoma is the most aggressive form of skin cancer and is extremely resistant to radiation and chemotherapy. One of the critical parameters of this resistance is down-regulation of Fas (CD95) cell-surface expression. Using TIG3 normal human fibroblasts and human melanoma cell lines, we investigated transcriptional regulation of FAP-1, a regulator of Fas translocation in the cell. Protein-tyrosine phosphatase FAP-1 (PTPN13, PTP-BAS) interacts with human Fas protein and prevents its export from the cytoplasm to the cell surface. In contrast, dynamin-2 facilitates Fas protein translocation from the Golgi apparatus via the trans-Golgi network to the cell surface. Suppression of dynamin functions by dominant negative dynamin K44A blocks Fas export, whereas the down-regulation of FAP-1 expression by specific RNA interference restores Fas export (a phenomenon that could still be down-regulated in the presence of dominant-negative dynamin). Based on the FAP-1- and dynamin-dependent regulation of Fas translocation, we have created human melanoma lines with different levels of surface expression of Fas. Treatment of these melanoma lines with soluble Fas ligand resulted in programmed cell death that was proportional to the pre-existing levels of surface Fas. Taking into consideration the well known observations that FAP-1 expression is often up-regulated in metastatic tumors, we have established a causal connection between high basal NF-κB transcription factor activity (which is a hallmark of many types of metastatic tumors) and NF-κB-dependent transcriptional regulation of FAP-1 gene expression that finally restricts Fas protein trafficking, thereby, facilitating the survival of cancer cells.
Additional file 1 of Gestational arsenic exposure induces site-specific DNA hypomethylation in active retrotransposon subfamilies in offspring sperm in mice
Creators: name: Nohara, Keiko
name: Nakabayashi, Kazuhiko
name: Okamura, Kazuyuki
name: Suzuki, Takehiro
name: Shigekatsu Suzuki
name: Hata, Kenichiro
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Figure S1. RRBS analysis of F1 sperm DNA that was obtained in another experiment. Number (A) and % in all CpGs (B) of hyper-/hypo-DMCs in each chromosome obtained in another independent experiment. Sperm was taken from cauda epididymis by pushed off the tissue with 26G needles in PBS, immediately transferred to a tube, and collected by centrifugation. DNA was prepared and RRBS analysis was carried out as described in the method. The sequencing was performed using an Illumina HiSeq 2500. The sequence data are publicly available at GEO with accession number GSE150500. Figure S2. Detailed annotation of all CpGs and hypo/hyperDMCs in all the genomic regions. Figure S5. Number (A) and % (B) of all CpGs classified in each chromosome using HOMER annotation. Figure S6. DNA methylation levels of imprinted DMRs that are methylated in the sperm. Figure S7. Hypo and hyperDMRs are categorized by detailed annotation as described in Method section. Table S1. The annotation and detailed annotation by HOMER. Table S2. DMRs at TSS ± 2,000 bp.
Additional file 1 of Patient involvement in quality improvement – a ‘tug of war’ or a dialogue in a learning process to improve healthcare?
Creators: name: Bergerum, Carolina
name: Engström, Agneta Kullén
name: Thor, Johan
name: Wolmesjö, Maria
Publisher: name: figshare
Year: 2020
Subjects: subject: Science Policy
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Marine Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: Additional file 1. Interview guide. Patients, next-of-kin, patient representatives. English version.
Search for top squarks in the four-body decay mode with single lepton final states in proton-proton collisions at $\sqrt{s}$ = 13 TeV
Creators: name: CMS Collaboration
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: A search for the pair production of the lightest supersymmetric partner of the top quark, the top squark ($\tilde{\mathrm{t}}_1$), is presented. The search targets the four-body decay of the $\tilde{\mathrm{t}}_1$, which is preferred when the mass difference between the top squark and the lightest supersymmetric particle is smaller than the mass of the W boson. This decay mode consists of a bottom quark, two other fermions, and the lightest neutralino ($\tildeχ^0_1$), which is assumed to be the lightest supersymmetric particle. The data correspond to an integrated luminosity of 138 fb$^{-1}$ of proton-proton collisions at a center-of-mass energy of 13 TeV collected by the CMS experiment at the CERN LHC. Events are selected using the presence of a high-momentum jet, an electron or muon with low transverse momentum, and a significant missing transverse momentum. The signal is selected based on a multivariate approach that is optimized for the difference between $m(\tilde{\mathrm{t}}_1)$ and $m(\tildeχ^0_1)$. The contribution from leading background processes is estimated from data. No significant excess is observed above the expectation from standard model processes. The results of this search exclude top squarks at 95% confidence level for masses up to 480 and 700 GeV for $m(\tilde{\mathrm{t}}_1) - m(\tildeχ^0_1$) = 10 and 80 GeV, respectively.
description: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at http://cms-results.web.cern.ch/cms-results/public-results/publications/SUS-21-003 (CMS Public Pages)
Disruption of IGF-1R Signaling Increases TRAIL-Induced Apoptosis: A New Potential Therapy for the Treatment of Melanoma
Creators: name: Ivanov, Vladimir N.
name: Hei, Tom K.
name: Karasic, Thomas B.
Publisher: name: Columbia University
Year: 2010
Subjects: Melanoma
Apoptosis
Cytology
Oncology

description: Resistance of cancer cells to apoptosis is dependent on a balance of multiple genetic and epigenetic mechanisms, which up-regulate efficacy of the surviving growth factor-receptor signaling pathways and suppress death-receptor signaling pathways. The Insulin-like Growth Factor-1 Receptor (IGF-1R) signaling pathway is highly active in metastatic melanoma cells by mediating downstream activation of PI3K-AKT and MAPK pathways and controlling general cell survival and proliferation. In the present study, we used human melanoma lines with established genotypes that represented different phases of cancer development: radial-growth-phase WM35, vertical-growth-phase WM793, metastatic LU1205 and WM9 [1]. All these lines have normal NRAS. WM35, WM793, LU1205 and WM9 cells have mutated BRAF (V600E). WM35 and WM9 cells express normal PTEN, while in WM793 cells PTEN expression is down-regulated; finally, in LU1205 cells PTEN is inactivated by mutation. Cyclolignan picropodophyllin (PPP), a specific inhibitor of IGF-1R kinase activity, strongly down-regulated the basal levels of AKT activity in WM9 and in WM793 cells, modestly does so in LU1205, but has no effect on AKT activity in the early stage WM35 cells that are deficient in IGF-1R. In addition, PPP partially down-regulated the basal levels of active ERK1/2 in all lines used, highlighting the role of an alternative, non-BRAF pathway in MAPK activation. The final result of PPP treatment was an induction of apoptosis in WM793, WM9 and LU1205 melanoma cells. On the other hand, dose-dependent inhibition of IGF-1R kinase activity by PPP at a relatively narrow dose range (near 500 nM) has different effects on melanoma cells versus normal cells, inducing apoptosis in cancer cells and G2/M arrest of fibroblasts. To further enhance the pro-apoptotic effects of PPP on melanoma cells, we used a combined treatment of TNF-Related Apoptosis-Inducing Ligand (TRAIL) and PPP. This combination substantially increased death by apoptosis for WM793 and WM9 cells, but did so only modestly for LU1205 cells with very high basal activity of AKT. The ultimate goal of this direction of research is the discovery of a new treatment method for highly resistant human metastatic melanomas. Our findings provide the rationale for further preclinical evaluation of this novel treatment.