cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
On plane algebroid curves
Creators: name: Barucci, Valentina
name: D'Anna, Marco
name: Froberg, Ralf
Publisher: name: arXiv
Year: 2003
Subjects: subject: Commutative Algebra (math.AC)
subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 13H15; 14B05

description: Two plane analytic branches are topologically equivalent if and only if they have the same multiplicity sequence. We show that having same semigroup is equivalent to having same multiplicity sequence, we calculate the semigroup from a parametrization, and we characterize semigroups for plane branches. These results are known, but the proofs are new. Furthermore we characterize multiplicity sequences of plane branches, and we prove that the associated graded ring, with respect to the values, of a plane branch is a complete intersection.
description: 14 pages
Causes of brain dysfunction in acute coma: a cohort study of 1027 patients in the emergency department
Creators: name: Schmidt, Wolf Ulrich
name: Ploner, Christoph J.
name: Lutz, Maximilian
name: Möckel, Martin
name: Lindner, Tobias
name: Braun, Mischa
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: brain dysfunction
subject: acute coma
subject: emergency medicine
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: BACKGROUND: Coma of unknown etiology (CUE) is a major challenge in emergency medicine. CUE is caused by a wide variety of pathologies that require immediate and targeted treatment. However, there is little empirical data guiding rational and efficient management of CUE. We present a detailed investigation on the causes of CUE in patients presenting to the ED of a university hospital. METHODS: One thousand twenty-seven consecutive ED patients with CUE were enrolled. Applying a retrospective observational study design, we analyzed all clinical, laboratory and imaging findings resulting from a standardized emergency work-up of each patient. Following a predefined protocol, we identified main and accessory coma-explaining pathologies and related these with (i.a.) GCS and in-hospital mortality. RESULTS: On admission, 854 of the 1027 patients presented with persistent CUE. Their main diagnoses were classified into acute primary brain lesions (39%), primary brain pathologies without acute lesions (25%) and pathologies that affected the brain secondarily (36%). In-hospital mortality associated with persistent CUE amounted to 25%. 33% of patients with persistent CUE presented with more than one coma-explaining pathology. In 173 of the 1027 patients, CUE had already resolved on admission. However, these patients showed a spectrum of main diagnoses similar to persistent CUE and a significant in-hospital mortality of 5%. CONCLUSION: The data from our cohort show that the spectrum of conditions underlying CUE is broad and may include a surprisingly high number of coincidences of multiple coma-explaining pathologies. This finding has not been reported so far. Thus, significant pathologies may be masked by initial findings and only appear at the end of the diagnostic work-up. Furthermore, even transient CUE showed a significant mortality, thus rendering GCS cutoffs for selection of high- and low-risk patients questionable. Taken together, our data advocate for a standardized diagnostic work-up that should be triggered by the emergency symptom CUE and not by any suspected diagnosis. This standardized routine should always be completed - even when initial coma-explaining diagnoses may seem evident.
Cheumatopsyche roscida
Creators: name: Oláh, János
name: Johanson, Kjell Arne
name: Barnard, Peter C.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Hydropsychidae
Cheumatopsyche
Cheumatopsyche roscida

description: Cheumatopsyche roscida (Navás, 1934)
 Hydropsychodes roscida Navás, 1934b: 71.
 Cheumatopsyche roscida (Navás, 1934); Kimmins 1963: 130.
 Type locality: Madagascar.
description: Published as part of Oláh, János, Johanson, Kjell Arne & Barnard, Peter C., 2008, Revision of the Oriental and Afrotropical species of Cheumatopsyche Wallengren (Hydropsychidae, Trichoptera), pp. 1-171 in Zootaxa 1738 on page 160
Severe infections of Panton-Valentine leukocidin positive Staphylococcus aureus in children
Creators: name: Hoppe, Pia-Alice
name: Holzhauer, Susanne
name: Lala, Birgit
name: Bührer, Christoph
name: Gratopp, Alexander
name: Hanitsch, Leif Gunnar
name: Humme, Daniel
name: Kieslich, Moritz
name: Kallinich, Tilmann
name: Lau, Susanne
name: Leistner, Rasmus
name: Niebank, Michaela
name: Pokrywka, Anna
name: Ringe, Hannelore
name: Schaper, Anne-Sophie
name: Schröder, Jennyver-Tabea
name: Schwarz, Carsten
name: Staab, Doris
name: Stegemann, Miriam Songa
name: Thee, Stephanie
name: Varnholt, Verena
name: Bernuth, Horst Von
name: Weber-Carstens, Steffen
name: Wendt, Anke
name: Krüger, Renate
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: children
subject: infection
subject: intensive care
subject: Panton-Valentine leukocidin
subject: Panton-Valentine leukocidin-positive Staphylococcus aureus
subject: PVL-SA
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Infections caused by Panton-Valentine leukocidin-positive Staphylococcus aureus (PVL-SA) mostly present as recurrent skin abscesses and furunculosis. However, life-threatening infections (eg, necrotizing pneumonia, necrotizing fasciitis, and osteomyelitis) caused by PVL-SA have also been reported.We assessed the clinical phenotype, frequency, clinical implications (surgery, length of treatment in hospitals/intensive care units, and antibiotic treatments), and potential preventability of severe PVL-SA infections in children.Total, 75 children treated for PVL-SA infections in our in- and outpatient units from 2012 to 2017 were included in this retrospective study.Ten out of 75 children contracted severe infections (PVL-methicillin resistant S aureus n = 4) including necrotizing pneumonia (n = 4), necrotizing fasciitis (n = 2), pyomyositis (n = 2; including 1 patient who also had pneumonia), mastoiditis with cerebellitis (n = 1), preorbital cellulitis (n = 1), and recurrent deep furunculosis in an immunosuppressed patient (n = 1). Specific complications of PVL-SA infections were venous thrombosis (n = 2), sepsis (n = 5), respiratory failure (n = 5), and acute respiratory distress syndrome (n = 3). The median duration of hospital stay was 14 days (range 5-52 days). In 6 out of 10 patients a history suggestive for PVL-SA colonization in the patient or close family members before hospital admission was identified.PVL-SA causes severe to life-threatening infections requiring lengthy treatments in hospital in a substantial percentage of symptomatic PVL-SA colonized children. More than 50% of severe infections might be prevented by prompt testing for PVL-SA in individuals with a history of abscesses or furunculosis, followed by decolonization measures.
Arp 299: a second merging system with two active nuclei?
Creators: name: Ballo, L.
name: Braito, V.
name: Della Ceca, R.
name: Maraschi, L.
name: Tavecchio, F.
name: Dadina, M.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Recent BeppoSAX observations of Arp 299, a powerful far-IR merging starburst system composed of IC 694 and NGC 3690, clearly unveiled for the first time in this system the presence of a strongly absorbed active galactic nucleus (AGN). However the system was not spatially resolved by BeppoSAX. Here we present the analysis of archival Chandra and (for the first time) XMM-Newton observations, which allow us to disentangle the X-ray emission of the two galaxies. The detection of a strong 6.4 keV line in NGC 3690 clearly demonstrates the existence of an AGN in this galaxy, while the presence of a strong 6.7 keV Fe-Kalpha line in the spectrum of IC 694 suggests that also this nucleus might harbor an AGN. This would be the second discovery of two AGNs in a merging system after NGC 6240.
description: 7 pages, 2 figures, Latex manuscript. Revised version after referee' comments; accepted for publication by ApJ (January 10, 2004)
A Sustainable UPLC-UV Method for Quantification of Donepezil Hydrochloride in Biorelevant Media Applied to Dissolution Profile Comparison
Creators: name: De Campos, Débora Priscila
name: Neila Márcia Silva-Barcellos
name: Marinho, Flávia Dias Marques
name: Barbosa, Guilherme Xavier
name: Victória Luiza Vieira Vidigal Lana
name: De Souza, Jacqueline
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Donepezil hydrochloride is one of the most prescribed anti-Alzheimer’s drugs, despite being available for more than two decades, chromatographic methods for the quantification of the drug in biorelevant media that mimics pH physiological conditions in vivo (pH 1.2, 4.5, 6.8) are not available in the literature. These media are used in the dissolution test, an important tool, for registration and quality control of medicines. Considering the need for methods with this purpose, this work aimed to develop and validate a sustainable UPLC-UV method for quantification of donepezil hydrochloride in tablets, specifically on assay and dissolution profile, with reduced environmental impacts. The proposed method has a run time of 2 min and requires for each run, only 0.8 mL of solvents, providing excellent green analysis. The method proved to be selective, linear, precise, accurate, robust in the range of 2-14 µg/mL. Three products (reference, similar and generic) were analyzed and showed very rapid dissolution. The average content varied from 100.2 ± 0.6% to 109.5 ± 2.1%. Using Dissolution Efficiency (DE), the drug release profiles were compared in different biorelevant media.
Cheumatopsyche masia
Creators: name: Oláh, János
name: Johanson, Kjell Arne
name: Barnard, Peter C.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Hydropsychidae
Cheumatopsyche
Cheumatopsyche masia

description: Cheumatopsyche masia (Navás, 1920)
 Hydropsychodes masia Navás, 1920: 8.
 Cheumatopsyche masia (Navás, 1920); Kimmins 1963: 130.
 Type locality: Philippines.
description: Published as part of Oláh, János, Johanson, Kjell Arne & Barnard, Peter C., 2008, Revision of the Oriental and Afrotropical species of Cheumatopsyche Wallengren (Hydropsychidae, Trichoptera), pp. 1-171 in Zootaxa 1738 on page 159
Absence of replica symmetry breaking in disordered FKG-Ising models under uniform field
Creators: name: Itoi, C.
name: Utsunomiya, Y.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Mathematical Physics (math-ph)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences
subject: 82B44

description: We prove that the variance of spin overlap vanishes in disordered Ising models satisfying the Fortuin-Kasteleyn-Ginibre (FKG) inequality under a uniform field, such as generally distributed random field Ising model, site- and bond-diluted Ising models with the Bernoulli distribution. Chatterjee's proof for the Gaussian random field Ising model is generalized to other independent identically distributed quenched disorder under a uniform field.
description: 14 pages
Givosiran: First Approval
Creators: name: Scott, Lesley J.
Publisher: name: Adis Journals
Year: 2020
Subjects: Medicine

description: Compliance with Ethical Standards Funding The preparation of this review was not supported by any external funding. Conflict of interest During the peer review process the manufacturer of the agent under review was offered an opportunity to comment on the article. Changes resulting from any comments received were made by the authors on the basis of scientific completeness and accuracy. Lesley Scott is a salaried employee of Adis International Ltd/Springer Nature, is responsible for the article content and declares no relevant conflicts of interest

AbstractGivosiran (Givlaari™) is an aminolevulinate synthase 1 (ALAS1)-directed small interfering RNA (siRNA) covalently linked to a ligand to enable specific delivery of the siRNA to hepatocytes. This results in downregulation of ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid and porphobilinogen levels that are associated with acute porphyria attacks. Givosiran is being developed by Alnylam Pharmaceuticals for the treatment of acute hepatic porphyria (AHP). In November 2019, givosiran was approved in the USA for the treatment of adults with AHP based on the positive results from the multinational, phase III ENVISION trial. In the EU, givosiran received a positive opinion in January 2020 for the treatment of AHP in adults and adolescents aged 12 years and older. This article summarizes the milestones in the development of givosiran leading to this first approval for the treatment of adults with AHP. © Springer Nature Switzerland AG 2020
Turmeric/Oregano Formulations for Treatment of Diabetic Ulcer Wounds
Creators: name: Sami, Diana G.
name: Abdellatif, Ahmed
name: Azzazy, Hassan M. E.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Diabetic wound infections and pressure ulcers pose a significant challenge to healthcare providers worldwide. The current study provides new and innovative wound care products that reduce inflammation, clear infection and improve healing in an animal model of pressure ulcers in diabetic rats. Ointment, hydrogel, and nanofiber dressings were synthesized using 5% turmeric, 1% oregano, and 1% chitosan nanoparticles and tested for antibacterial and cytotoxicity in vitro, and wound healing effects in vivo. Turmeric ethanolic extract showed high antioxidant activity compared to Oregano, Chitosan Nanoparticles, and Alginate silver (P-value <0.0001). The ointment and hydrogel formulation (5% Turmeric, 1% Oregano, and 1% chitosan) showed lower cytotoxicity compared to the commercial Alginate silver dressing. Ointment, hydrogel formulations, and commercial Alginate silver, showed significant antibacterial activity with 100% efficacy on both S. aureus and E. coli (P-value <0.0001), compared to nanofibers which showed 50% reduction in bacterial growth (P-value <0.0001). The new formulations were tested in a rat model of pressure ulcers. Ointment and nanofibers achieved complete wound healing by day 15 compared to the hydrogel and commercial Alginate silver dressing, which showed higher infection, and the wound remained partially open by day 21. In conclusion, Turmeric, Oregano extracts, and chitosan nanoparticles can be used for effective wound dressings in both diabetic and non-diabetic wounds. At relatively low concentrations, this combination provides a promising new wound treatment formulation that is antibacterial, anti-inflammatory, and antioxidant.
Nonparametric sign prediction of high-dimensional correlation matrix coefficients
Creators: name: Bongiorno, Christian
name: Challet, Damien
Publisher: name: arXiv
Year: 2020
Subjects: subject: General Finance (q-fin.GN)
subject: Statistical Finance (q-fin.ST)
subject: Applications (stat.AP)
subject: FOS: Economics and business
subject: FOS: Computer and information sciences

description: We introduce a method to predict which correlation matrix coefficients are likely to change their signs in the future in the high-dimensional regime, i.e. when the number of features is larger than the number of samples per feature. The stability of correlation signs, two-by-two relationships, is found to depend on three-by-three relationships inspired by Heider social cohesion theory in this regime. We apply our method to US and Hong Kong equities historical data to illustrate how the structure of correlation matrices influences the stability of the sign of its coefficients.
Additional file 3 of TRIM proteins in hepatocellular carcinoma
Creators: name: Lu, Kan
name: Pan, Yonglong
name: Huang, Zhao
name: Liang, Huifang
name: Ding, Ze-yang
name: Zhang, Bixiang
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Virology

description: Additional file 3: Fig. S2. A univariate cox analysis of every 75 TRIM proteins based on TCGA-LIHC dataset with p < 0.05.
Bourletiella (Bourletiella) radula Nayrolles 1995
Creators: name: Thibaud, Jean-Marc
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Symphypleona
Bourletiellidae
Bourletiella
Bourletiella radula

description: Bourletiella (Bourletiella) radula Gisin, 1946 sensu Nayrolles 1995 *
Bourletiella (Bourletiella) radula Gisin, 1946a: 260. — Bretfeld 1999: 230.
Bourletiella radula – Nayrolles 1995a: 47. — Ellis 1975: 77.
DISTRIBUTION. — Ardèche. Puits de M. Nouelle prèsde Saint- Alban-sous-Sampzon; puits supérieur de la Bastide-sous-Sampzon prèsde Grospierres (Thibaud & Stomp 1978).
Aude. Ussonet Carcanet (Bonnet etal. 1979).
Aveyron. Prairies del’Aubrac (Raynal 1973, 1974).
Hautes-Pyrénées. Massif du Néouvielle (Cassagnau 1961, 1963, 1964c). — Valléed’Aure (Cassagnau 1964a; Lauga-Reyrel & Lauga 1995). — Lac d’Aumar, 2200 m (Cassagnau et al. 1968; Nayrolles 1995a). — Prairies au lac d’Orédon, cirque de l’Estaragneet auplateau d’Aumar (Raynal 1973). — Piaud’Engaly (Bonnet et al. 1979).
Lozère. Nasbinal, près de lac Souvérols (Nayrolles 1995a).
Pyrénées-Orientales. Station de ski de Calmazeille-Formiguères (Gers & Izarra 1983).
TAXONOMIE. — Nayrolles 1995a (redescription). ÉCOMORPHOSE. — Cassagnau 1963 (neutralisation phénotypique); Raynal 1974.
DÉVELOPPEMENT. — Cassagnau 1964c (développement et sexualité).
PHYSIOLOGIE. — Cassagnau et al. 1968 (complexe cérébral neurosécréteur).
ÉCOLOGIE. — Cassagnau 1964c; Bonnet etal. 1979 (déboisement, reboisement); Gers & Izarra 1983 (biocénose).
COMPORTEMENT. — Raynal 1973 (comportement reproducteur).
description: Published as part of Thibaud, Jean-Marc, 2017, Catalogue des collemboles de France, pp. 297-436 in Zoosystema 39 (3) on page 399, DOI: 10.5252/z2017n3a1, http://zenodo.org/record/5496272
CIN2+ detection of the HPV DNA Array genotyping assay in comparison with the Cobas 4800 HPV test and cytology
Creators: name: Pesic, Aleksandra
name: Krings, Amrei
name: Hempel, Matthias
name: Preyer, Rosemarie
name: Chatzistamatiou, Kimon
name: Agorastos, Theodoros
name: Kaufmann, Andreas M.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: Cervical Cancer
subject: HPV assay
subject: HPV detection
subject: Human papillomavirus
subject: Validation
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: BACKGROUND: HPV DNA Array is an E1-targeting PCR genotyping test, with capability of distinguishing 18 high-risk (16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, 82) and 11 low-risk HPV types (6, 11, 40, 42, 44, 54, 67, 69, 70, 85, 97). HPV DNA Array uses multiplex PCR for E1-gene sequence amplification. The amplicons are detected and genotyped by reverse hybridization to immobilized DNA probes spotted as triplets in single 96 well-plate wells and read by AID ELISPOT reader. METHODS: Aim of the study was to evaluate the clinical performance of the assay against internationally accepted and FDA approved Cobas 4800 HPV test (Roche Diagnostics). Study population comprised of 500 cervical samples. RESULTS: HPV DNA Array demonstrated a very high sensitivity of 100% for CIN2+ and 100% for CIN3+ detection, same as Cobas 4800. HPV DNA Array showed greater sensitivity for CIN2+ detection than cytology (100% vs. 13.6%). The agreement to Cobas 4800 for HPV detection, irrespective of type, was 81.4% with κ = 0.613. The agreement for HPV 16 was 92.8% (κ = 0.929), and for HPV 18 54.2% (κ = 0.681). CONCLUSION: HPV DNA Array demonstrated good clinical performance for detection of high-grade lesions, and may be considered for usage in a screening setting.
Cheumatopsyche meruana Navas 1934
Creators: name: Oláh, János
name: Johanson, Kjell Arne
name: Barnard, Peter C.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Hydropsychidae
Cheumatopsyche
Cheumatopsyche meruana

description: Cheumatopsyche meruana Navás, 1934
 Cheumatopsyche meruana Navás, 1934a: 21.
 Type locality: Kenya.
description: Published as part of Oláh, János, Johanson, Kjell Arne & Barnard, Peter C., 2008, Revision of the Oriental and Afrotropical species of Cheumatopsyche Wallengren (Hydropsychidae, Trichoptera), pp. 1-171 in Zootaxa 1738 on page 160
The $\ell^p$-metrization of functors with finite supports
Creators: name: Banakh, T.
name: Brydun, V.
name: Karchevska, L.
name: Zarichnyi, M.
Publisher: name: arXiv
Year: 2020
Subjects: subject: General Topology (math.GN)
subject: Category Theory (math.CT)
subject: Metric Geometry (math.MG)
subject: FOS: Mathematics
subject: 54B30, 54E35, 54F45

description: Let $p\in[1,\infty]$ and $F:\mathbf{Set}\to\mathbf{Set}$ be a functor with finite supports in the category $\mathbf{Set}$ of sets. Given a non-empty metric space $(X,d_X)$, we introduce the distance $d^p_{FX}$ on the functor-space $FX$ as the largest distance such that for every $n\in\mathbb N$ and $a\in Fn$ the map $X^n\to FX$, $f\mapsto Ff(a)$, is non-expanding with respect to the $\ell^p$-metric $d^p_{X^n}$ on $X^n$. We prove that the distance $d^p_{FX}$ is a pseudometric if and only if the functor $F$ preserves singletons; $d^p_{FX}$ is a metric if $F$ preserves singletons and one of the following conditions holds: (1) the metric space $(X,d_X)$ is Lipschitz disconnected, (2) $p=1$, (3) the functor $F$ has finite degree, (4) $F$ preserves supports. We prove that for any Lipschitz map $f:(X,d_X)\to (Y,d_Y)$ between metric spaces the map $Ff:(FX,d^p_{FX})\to (FY,d^p_{FY})$ is Lipschitz with Lipschitz constant $\mathrm{Lip}(Ff)\le \mathrm{Lip}(f)$. If the functor $F$ is finitary, has finite degree (and preserves supports), then $F$ preserves uniformly continuous function, coarse functions, coarse equivalences, asymptotically Lipschitz functions, quasi-isometries (and continuous functions). For many dimension functions we prove the formula $\dim F^pX\le\mathrm{deg}(F)\cdot\dim X$. Using injective envelopes, we introduce a modification $\check d^p_{FX}$ of the distance $d^p_{FX}$ and prove that the functor $\check F^p:\mathbf{Dist}\to\mathbf{Dist}$, $\check F^p:(X,d_X)\mapsto (FX,\check d^p_{FX})$, in the category $\mathbf{Dist}$ of distance spaces preserves Lipschitz maps and isometries between metric spaces.
description: 79 pages
Theory and practice of microlensing lightcurves around fold singularities
Creators: name: Dominik, M.
Publisher: name: arXiv
Year: 2003
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Among all galactic microlensing events, those involving a passage of the observed source star over the caustic created by a binary lens are particularly useful in providing information about stellar atmospheres, the dynamics of stellar populations in our own and neighbouring galaxies, and the statistical properties of stellar and sub-stellar binaries. This paper presents a comprehensive guide for modelling and interpreting the lightcurves obtained in events involving fold-caustic crossings. A new general, consistent, and optimal choice of parameters provides a deep understanding of the involved features, avoids numerical difficulties and minimizes correlations between model parameters. While the photometric data of a microlensing event around a caustic crossing itself do not provide constraints on the characteristics of the underlying binary lens and does not allow predictions of the behaviour of other regions of the lightcurve, vital constraints can be obtained in an efficient way if these are combined with a few simple characteristics of data outside the caustic crossings. A corresponding algorithm containing some improvements over an earlier approach which takes into account multi-site observations is presented and discussed in detail together with the arising parameter constraints paying special attention to the role of source and background fluxes.
description: 19 pages with 7 EPS figures embedded, LaTeX2e using mn2e.cls. Final version, tables clarifying meaning and constraints on parameters added. This is a preprint of an Article accepted for publication in Monthly Notices of the Royal Astronomical Society, (C) 2004 The Royal Astronomical Society
A case report of cutaneous mucormycosis of the hand after minor trauma in a patient with acute myeloid leukaemia
Creators: name: Maleitzke, Tazio
name: Stahnke, Katharina
name: Trampuz, Andrej
name: Märdian, Sven
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: Cutaneous mucormycosis
subject: Fungal infection
subject: Mucorales
subject: Immunosuppression
subject: Leukaemia
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Mucormycosis is a rare but life-threatening infection, caused by fungi of the Mucorales order, which can be found in soil, rotting leaves or on animals. Through characteristic angioinvasive growth, infections with mucor spores can occur as a pulmonary, rhinocerebral or cutaneous form. Infections mainly affect immunosuppressed patients with a history of uncontrolled diabetes or haematological malignancies, among others. Treatment is multimodal and requires an immediate combination of intravenous amphotericin B therapy and serial surgical debridements. Only a limited number of cases of cutaneous mucormycosis of the hand have been documented and described previously. Case presentation: We report a cutaneous mucormycosis in an elderly patient with a therapy-resistant acute myeloid leukaemia after a minor trauma on his right hand, sustained whilst gardening. The fungal infection was treated with serial radical debridements, vacuum-assisted negative-pressure wound closure technique and intravenous antifungals. Despite successful eradication of the fungal infection, a palliative open wound care concept was implemented during the terminal course of the patient's leukaemia. Conclusions: Cutaneous mucormycosis is a rare but fulminant fungal infection mostly affecting immunosuppressed patients. Survival is possible when diagnosed and treated early, yet mortality rates remain high.
Idealised simulations of the deep atmosphere of hot jupiters: Deep, hot, adiabats as a robust solution to the radius inflation problem
Creators: name: Sainsbury-Martinez, F.
name: Wang, P.
name: Fromang, S.
name: Tremblin, P.
name: Dubos, T.
name: Meurdesoif, Y.
name: Spiga, A.
name: Leconte, J.
name: Baraffe, I.
name: Chabrier, G.
name: Mayne, N.
name: Drummond, B.
name: Debras, F.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Context: The anomalously large radii of hot Jupiters has long been a mystery. However, by combining both theoretical arguments and 2D models, a recent study has suggested that the vertical advection of potential temperature leads to an adiabatic temperature profile in the deep atmosphere hotter than the profile obtained with standard 1D models. Aims: In order to confirm the viability of that scenario, we extend this investigation to three dimensional, time-dependent, models. Methods: We use a 3D GCM, DYNAMICO to perform a series of calculations designed to explore the formation and structure of the driving atmospheric circulations, and detail how it responds to changes in both upper and deep atmospheric forcing. Results: In agreement with the previous, 2D, study, we find that a hot adiabat is the natural outcome of the long-term evolution of the deep atmosphere. Integration times of order $1500$ years are needed for that adiabat to emerge from an isothermal atmosphere, explaining why it has not been found in previous hot Jupiter studies. Models initialised from a hotter deep atmosphere tend to evolve faster toward the same final state. We also find that the deep adiabat is stable against low-levels of deep heating and cooling, as long as the Newtonian cooling time-scale is longer than $\sim 3000$ years at $200$ bar. Conclusions: We conclude that the steady-state vertical advection of potential temperature by deep atmospheric circulations constitutes a robust mechanism to explain hot Jupiter inflated radii. We suggest that future studies of hot Jupiters are evolved for a longer time than currently done, and, when possible, include models initialised with a hot deep adiabat. We stress that this mechanism stems from the advection of entropy by irradiation induced mass flows and does not require (finely tuned) dissipative process, in contrast with most previously suggested scenarios.
description: 13 pages, 12 figures. Accepted for publication in A&A
Weak disorder expansion for localization lengths of quasi-1D systems
Creators: name: Roemer, Rudolf A.
name: Schulz-Baldes, Hermann
Publisher: name: arXiv
Year: 2004
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: A perturbative formula for the lowest Lyapunov exponent of an Anderson model on a strip is presented. It is expressed in terms of an energy dependent doubly stochastic matrix, the size of which is proportional to the strip width. This matrix and the resulting perturbative expression for the Lyapunov exponent are evaluated numerically. Dependence on energy, strip width and disorder strength are thoroughly compared with the results obtained by the standard transfer matrix method. Good agreement is found for all energies in the band of the free operator and this even for quite large values of the disorder strength.
description: 4 pages with 5 .eps figures included
Cheumatopsyche pallida
Creators: name: Oláh, János
name: Johanson, Kjell Arne
name: Barnard, Peter C.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Hydropsychidae
Cheumatopsyche
Cheumatopsyche pallida

description: Cheumatopsyche pallida (Banks, 1920)
 Hydropsyche pallida Banks, 1920: 357.
 Hydropsychodes pallida (Banks, 1920); Ulmer 1931: 1.
 Cheumatopsyche pallida (Banks, 1920); Kimmins 1963: 130.
 Type locality: Madagascar.
description: Published as part of Oláh, János, Johanson, Kjell Arne & Barnard, Peter C., 2008, Revision of the Oriental and Afrotropical species of Cheumatopsyche Wallengren (Hydropsychidae, Trichoptera), pp. 1-171 in Zootaxa 1738 on page 160
Essays on Entrepreneurs and Taxation
Creators: name: Arm, Nakornthab
Publisher: name: The Australian National University
Year: 2018
Subjects: Taxation
Entrepreneurship
Annuity
Top income
Wealth tax

description: Apart from the introduction and conclusion, this thesis consists of three chapters focusing on taxation in the model with entrepreneurship. Using a simplified life-cycle structure, these three chapters aim to give policy implications regarding various kind of taxes in the U.S. economy. The focus is more involved with tax at the top wealth or income distribution, which necessitates the model capable of capturing the wealth distribution correctly. Including entrepreneurship in the model is one of the available approaches for replicating the U.S. wealth distribution. In chapter 2 (joint with Çagri Kumru) we study the interaction between estate taxation and annuity demand both analytically and quantitatively. Having entrepreneurs yields a novel finding for annuity demands of non-entrepreneurs (workers) and entrepreneurs. The simple analytical model shows that lower estate tax rates result in lower annuity demands. The quantitative model shows that annuity demand is indeed sensitive to the changes in the estate tax system. Removing the estate tax rate reduces the annuity demand substantially when the government’s budget is balanced with an increase in the proportional income tax rate. Removing the exemption level generates the most striking result that if all individuals face the estate tax, the annuity ownership rate increases dramatically. In chapter 3 (joint with Ayse Imrohoroglu and Çagri Kumru), we study optimal income taxation in a model with entrepreneurial activity. We conduct two types of changes in tax policy: changing the overall progressivity of taxes versus changing the tax rate of the richest one percent of the population. We study the implications of these tax policies on welfare, inequality, and government revenues. The results indicate that increasing the overall progressivity of taxes results in lower wealth inequality and higher welfare relative to increasing the tax rate on the richest one percent of the population. In chapter 4, I analyze the implications of the capital income tax, the wealth tax, and the estate tax on economic aggregates and welfare and search for the optimal wealth tax rate. When capital income tax is replaced by the wealth tax, there is a modest welfare gain. In contrast, replacing the current estate tax system with a wealth tax system leads to an overall welfare loss. The highest welfare gain is realized when the capital income tax is replaced by wealth tax at the top. Finally, the optimal wealth tax rate as 5.75 percent. Although the optimal wealth tax increases welfare substantially, it makes wealth inequality even worse.
Tilivalline- and Tilimycin-Independent Effects of Klebsiella oxytoca on Tight Junction-Mediated Intestinal Barrier Impairment
Creators: name: Hering, Nina A.
name: Fromm, Anja
name: Bücker, Roland
name: Gorkiewicz, Gregor
name: Zechner, Ellen
name: Högenauer, Christoph
name: Fromm, Michael
name: Schulzke, Jörg-Dieter
name: Troeger, Hanno
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: antibiotic-associated hemorrhagic colitis
subject: tight junction
subject: claudin
subject: apoptosis
subject: Klebsiella oxytoca
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Klebsiella oxytoca causes antibiotic-associated hemorrhagic colitis and diarrhea. This was attributed largely to its secreted cytotoxins tilivalline and tilimycin, inductors of epithelial apoptosis. To study whether Klebsiella oxytoca exerts further barrier effects, T84 monolayers were challenged with bacterial supernatants derived from tilivalline/tilimycin-producing AHC6 or its isogeneic tilivalline/tilimycin-deficient strain Mut-89. Both preparations decreased transepithelial resistance, enhanced fluorescein and FITC-dextran-4kDa permeabilities, and reduced expression of barrier-forming tight junction proteins claudin-5 and -8. Laser scanning microscopy indicated redistribution of both claudins off the tight junction region in T84 monolayers as well as in colon crypts of mice infected with AHC6 or Mut-89, indicating that these effects are tilivalline/tilimycin-independent. Furthermore, claudin-1 was affected, but only in a tilivalline/tilimycin-dependent manner. In conclusion, Klebsiella oxytoca induced intestinal barrier impairment by two mechanisms: the tilivalline/tilimycin-dependent one, acting by increasing cellular apoptosis and a tilivalline/tilimycin-independent one, acting by weakening the paracellular pathway through the tight junction proteins claudin-5 and -8.
Essays on Individual Behavior in Education and Sports
Creators: name: Lensing, Fabian
Publisher: name: Universität Paderborn
Year: 2022

description: Ökonomen haben bereits im 18. Jahrhundert postuliert, dass das gesamtgesellschaftliche und -wirtschaftliche Verhalten Ergebnis von Entscheidungen und Verhalten einzelner Individuen ist. Auf Basis dieser Überlegungen und Theorien hat sich ein breiter wissenschaftlicher Diskurs ergeben, um die Entscheidungen und das Verhalten einzelner Individuen besser verstehen zu können, u.a. vor dem Hintergrund des Rationalitätsbegriffs. Die vorliegende Dissertation trägt diesen Diskussionen rund um diesen Themenkomplex neue und ergänzende Erkenntnisse in insgesamt vier Aufsätzen aus den Bereichen Bildung und Sport bei. Ziel ist es, mithilfe existierender ökonomischer Theorien und anhand ökonometrischer Modelle und Schätzverfahren die dem Verhalten Einzelner zugrundeliegenden Mechanismen zu untersuchen. Aus den Ergebnissen können Erkenntnisse für Theorie und Praxis gewonnen werden, die dabei helfen können, das Verhalten einzelner Individuen besser verstehen und einordnen und so auch proaktiv adressieren zu können.
description: As early as the eighteenth century, economists had discovered that aggregate social and economic behavior is a result of decisions and behavior at an individual level. Based upon these concepts and theories, a broad scientific discourse has emerged in order to better understand the decisions and behavior of individuals, i.a. with regards to its rationality. This dissertation contributes new and additional findings from, in total, four essays in the fields of education and sports to these discussions around individual behavior. The aim is to investigate the underlying mechanisms of individual behavior by using existing economic theories and econometric models and estimations. The implications for theory and practice derived from the results can help to better understand and proactively address individual behavior.
D-branes, B fields, and Ext groups
Creators: name: Caldararu, A.
name: Katz, S.
name: Sharpe, E.
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Algebraic Geometry (math.AG)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: In this paper we extend previous work on calculating massless boundary Ramond sector spectra of open strings to include cases with nonzero flat B fields. In such cases, D-branes are no longer well-modelled precisely by sheaves, but rather they are replaced by `twisted' sheaves, reflecting the fact that gauge transformations of the B field act as affine translations of the Chan-Paton factors. As in previous work, we find that the massless boundary Ramond sector states are counted by Ext groups -- this time, Ext groups of twisted sheaves. As before, the computation of BRST cohomology relies on physically realizing some spectral sequences. Subtleties that cropped up in previous work also appear here.
description: 23 pages, LaTeX; v2: typos fixed; v3: reference added
Asymptotically flat vacuum solution in modified theory of Einstein's gravity
Creators: name: Kalita, Surajit
name: Mukhopadhyay, Banibrata
Publisher: name: arXiv
Year: 2019
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: A number of recent observations have suggested that the Einstein's theory of general relativity may not be the ultimate theory of gravity. The f(R) gravity model with R being the scalar curvature turns out to be one of the best bet to surpass the general relativity which explains a number of phenomena where Einstein's theory of gravity fails. In the f(R) gravity, behaviour of the spacetime is modified as compared to that of given by the Einstein's theory of general relativity. This theory has already been explored for understanding various compact objects such as neutron stars, white dwarfs etc. and also describing evolution of the universe. Although, researchers have already found the vacuum spacetime solutions for the f(R) gravity, yet there is a caveat that the metric does have some diverging terms and hence these solutions are not asymptotically flat. We show that it is possible to have asymptotically flat spherically symmetric vacuum solution for the f(R) gravity, which is different from the Schwarzschild solution. We use this solution for explaining various bound orbits around the black hole and eventually, as an immediate application, in the spherical accretion flow around it.
description: 8 pages including 5 figures; accepted for publication in European Physical Journal C
The toxicological effect of 4-week repeated intravenous injection of activin a/BMP-2 chimera and 2-week recovery study in Beagle dog*
Creators: name: Han, Shi Huan
name: Zheng, Guang Bin
name: Lee, Jae Hyup
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences

description: The purposes of this study was to determine the toxicological effect of repeated intravenous administration of Activin A/BMP-2 chimera (AB204) in beagle dogs for a long period of four weeks and evaluate two-week recovery. AB204 was administered at doses of 0.08, 0.16, or 0.32 mg/kg/day to three male and three female beagle dogs for 4 weeks as the experimental group. For the control group, sterile saline was administered to three male and three female beagle dogs. For the two-week recovery test, two male and two female beagle dogs were randomly selected from the control group and the 0.32 mg/kg/day administered experimental group. General symptoms, body weight, food consumption, ophthalmological examination, electrocardiogram, urinalysis, hematology and blood biochemistry, organ weights, autopsy, and histopathological examination were observed or conducted. No animals died. There was no significant difference in any parameter evaluated between the experimental group and the control group. Histopathological examination revealed compound inflammation at the administration site in both the experimental group and the control group. The inflammation disappeared during the two-week recovery. These results indicated that repetitive intravenous injection of AB204 in beagle dog for a long period of four weeks did not show any toxicity. Therefore, no observed adverse effects level (NOAEL) of AB204 was 0.32 mg/kg/day in big animal model.
Vitamin C alleviates acute enterocolitis in Campylobacter jejuni infected mice
Creators: name: Mousavi, Soraya
name: Escher, Ulrike
name: Thunhorst, Elisa
name: Kittler, Sophie
name: Kehrenberg, Corinna
name: Bereswill, Stefan
name: Heimesaat, Markus M.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Campylobacter jejuni
subject: Vitamin C (ascorbate)
subject: IL-10 −/− mice
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Human foodborne infections with the zoonotic pathogen Campylobacter jejuni are on the rise and constitute a significant socioeconomic burden worldwide. The health-beneficial, particularly anti-inflammatory effects of vitamin C (ascorbate) are well known. In our preclinical intervention study, we assessed potential anti-pathogenic and immunomodulatory effects of ascorbate in C. jejuni-infected secondary abiotic IL-10-/- mice developing acute campylobacteriosis similar to humans. Starting 4 days prior peroral C. jejuni-infection, mice received synthetic ascorbate via the drinking water until the end of the experiment. At day 6 post-infection, ascorbate-treated mice harbored slightly lower colonic pathogen loads and suffered from less severe C. jejuni-induced enterocolitis as compared to placebo control animals. Ascorbate treatment did not only alleviate macroscopic sequelae of infection, but also dampened apoptotic and inflammatory immune cell responses in the intestines that were accompanied by less pronounced pro-inflammatory cytokine secretion. Remarkably, the anti-inflammatory effects of ascorbate pretreatment in C. jejuni-infected mice were not restricted to the intestinal tract but could also be observed in extra-intestinal compartments including liver, kidneys and lungs. In conclusion, due to the potent anti-inflammatory effects observed in the clinical murine C. jejuni-infection model, ascorbate constitutes a promising novel option for prophylaxis and treatment of acute campylobacteriosis.
Cheumatopsyche ulmeri
Creators: name: Oláh, János
name: Johanson, Kjell Arne
name: Barnard, Peter C.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Trichoptera
Hydropsychidae
Cheumatopsyche
Cheumatopsyche ulmeri

description: Cheumatopsyche ulmeri (Navás, 1933)
 Hydropsychodes ulmeri Navás, 1933: 100
 Cheumatopsyche ulmeri (Navás, 1933); Kimmins 1963: 130.
 Type locality: Taiwan.
description: Published as part of Oláh, János, Johanson, Kjell Arne & Barnard, Peter C., 2008, Revision of the Oriental and Afrotropical species of Cheumatopsyche Wallengren (Hydropsychidae, Trichoptera), pp. 1-171 in Zootaxa 1738 on page 161
Expression of Epstein-Barr virus genes in different cell types after microinjection of viral DNA
Creators: name: Graessmann, A.
name: Wolf, Hans J.
name: Bornkamm, G. W.
Publisher: name: Universität Regensburg
Year: 1980
Subjects: subject: 610 Medizin
subject: Animals
subject: Antigens, Viral/genetics
subject: Cells, Cultured
subject: Cercopithecus aethiops
subject: DNA, Viral/genetics
subject: Enzyme Induction
subject: Genes, Viral
subject: Haplorhini
subject: Herpesvirus 4, Human/genetics
subject: Humans
subject: Microinjections
subject: Rats
subject: Thymidine Kinase/metabolism
subject: Viral Proteins/genetics

description: Gene expression of Epstein-Barr virus (EBV) was studied after microinjection of viral DNA into different types of cells. Raji TK- cells, known to express viral gene functions after superinfection with the EBV-P3HR-1 virus strain, were attached to plastic dishes by using anti-lymphocyte IgG, phytohemagglutinin, or concanavalin A as a ligand. It was difficult to inject DNA into the small and fragile Raji cells. After formation of polykaryons by cell fusion, microinjection became more efficient. At 24 hr after injection of P3HR-1 virus DNA, 90-100% of the injected cells expressed the early antigen complex as observed by immunofluorescence staining; 70-80% of the cells simultaneously incorported [3H]thymidine, indicating that thymidine kinase is expressed after injection of viral DNA. Additionally, synthesis of the virus capsid antigen was demonstrated in 20-30% of the recipient Raji cells. Human diploid fibroblasts, African green monkey kidney cells, and rat fibroblasts, which do not represent natural target cells for EBV, could also be induced to synthesis of early antigen complex by injection of P3HR-1 virus DNA.