cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A new phenylimidorhenium(V) compound containing the 2-[(2-hydroxyethylimino)methyl]phenol Schiff-base ligand: experimental and theoretical aspects
Creators: name: Majumder, Smita
name: Jnan Prakash Naskar
name: Arnab Bhattacharya
name: Ganguly, Rakesh
name: Pinki Saha
name: Shubhamoy Chowdhury
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Chemistry
Earth and Environmental Sciences
Biotechnology
Cell Biology
Biochemistry

description: Reaction of equimolar trans-[Re(NPh)(PPh3)2Cl3] with H2L, a 1 : 1 Schiff-base condensate of salicylaldehyde and ethanolamine, in chloroform gives trans-[Re(NPh)(HL)(PPh3)Cl2] (1a) in good yield. 1a has been characterized by C, H, and N microanalyses, FTIR and UV–vis spectra. The X-ray crystal structure of 1a reveals that it is an octahedral trans-Cl,Cl phenylimidorhenium(V) complex. The rhenium center has an ‘N2OCl2P’ coordination sphere. 1a crystallizes in the monoclinic space group P21/c with a = 11.2391(5), b = 16.4848(7), c = 16.3761(8) Å, V = 3034.0(2) Å3 and Z = 4. The electrochemical aspects of 1a have been studied. Electrochemical studies of 1a in dichloromethane show a quasi-reversible Re(V) to Re(VI) oxidation at 1.128 V versus Ag/AgCl. This redox potential reasonably matches the calculated redox potential, 1.186 V versus Ag/AgCl. Geometry optimization of the trans-Cl,Cl1a vis-à-vis its cis analog, cis-Cl,Cl1b, have been performed at the level of density functional theory (DFT). It is revealed that 1a is more stable than 1b by 21.6 kcal per mole of energy in the gas phase.
Additional file 1 of A critical review of definitions of rural areas in Indonesia and implications for health workforce policy and research
Creators: name: Putri, Likke Prawidya
name: Russell, Deborah Jane
name: O’Sullivan, Belinda Gabrielle
name: Meliala, Andreasta
name: Kippen, Rebecca
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Cancer
subject: Science Policy

description: Additional file 1. Table 1A Selected policies with rural-area definitions that are related to health policy. Table 2A Rural area definitions identified. Table 3A Proportion of rural villages and less developed districts in 34 Provinces, 2018. Table 4A Scoring of Ministry of Health definition of remote health facilities. Table 5A Scoring of the Presidential-regulated definition of less-developed districts. Table 6A Scoring of Central Bureau of Statistics definition of urban-rural village. Table 7A Districts according to the Ministry of Health (MoH), Presidential, and Central Bureau of Statistics (CBS) rural area definitions.
Additional file 12 of Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder
Creators: name: Czamara, Darina
name: Neufang, Alexa
name: Dieterle, Roman
name: Iurato, Stella
name: Arloth, Janine
name: Martins, Jade
name: Ising, Marcus
name: Binder, Elisabeth E.
name: Erhardt, Angelika
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 12: Figure S11. Manhattan plot for EWAS of wLE x case-control-status in PDI. Chromosomal position is depicted on the x-axis, −log10(p-value) on the y-axis. The blue line indicates nominal p-values <1.0 × 10−05 (A). QQ-plot for EWAS of wLE x case-control-status in PDI depicting expected −log10(p-values) versus observed −log10(p-values). The lambda-value is 1.02 (B).
Natural anti-A and Tn-cross-reactive IgM arise from developmental O-GalNAc glycosylations.*
Creators: name: Arend, Peter
Publisher: name: figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Hematology
subject: Medicine
subject: Biochemistry
subject: Developmental Biology
subject: Zoology
subject: 60114 Systems Biology
subject: Structural Biology
subject: Stem Cells
subject: Cell Biology
subject: Genetics

description: While native blood group A-like glycans have not been demonstrated in prokaryotic microorganisms as a source of the human “natural” anti-A/B isoagglutinin production and the trans-species, vertebrate O-GalNAc-Ser/Thr glycosylations do not occur in bacteria, the O-GalNAc glycan-bearing ovarian glycolipids, discovered in C57BL/10 mice, are complementary to the syngeneic anti-A-reactive immunoglobulin M (IgM), which does not appear in animals that underwent ovariectomy prior to the onset of puberty. This murine anti-A “auto” antibody and the human innate anti-A isoagglutinin, which is distinct from adaptive, cross-reactive anti-A/B reactivities, show identical serological reaction patterns. In mouse and man, this non-immune antibody molecule most likely obtains its complementarity from the early trans-species O-GalNAc glycosylation of proteins and subsequent GalNAc transferase depletion, which completes the cell differentiation processes and results in the release of characteristic O-glycan-depleted, complementary proteins, such as the secretory IgM that might reveal the structure of the volatilely expressed, “lost” glycan through germline-specific serine residues. Consequently, the early or first O-GalNAc glycosylations of proteins appear metabolically related to those of the mucin-type, “aberrant” monosaccharide GalNAcα1-O-Ser/Thr-R also referred to the Tn antigen and explain the anti-Tn cross-reactivity of anti-A-specific immunoglobulins and the pronounced occurrence of cross-reactive anti-Tn antibody in plasma from humans of histo (blood) group O. In fact, in the human blood group O, an A-allelic, phenotype-specific GalNAc glycosylation of plasma proteins does not occur, impacting the levels of the anti-Tn antibody, which may function as a growth regulator that depending on its levels, may initiate a complex process of growth inhibition through enzyme-substrate competition with subsequent trans-species O-GalNAc-glycosylations.
Additional file 13 of Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder
Creators: name: Czamara, Darina
name: Neufang, Alexa
name: Dieterle, Roman
name: Iurato, Stella
name: Arloth, Janine
name: Martins, Jade
name: Ising, Marcus
name: Binder, Elisabeth E.
name: Erhardt, Angelika
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 13: Figure S12. Manhattan plot for EWAS of wLE x case-control-status in PDII. Chromosomal position is depicted on the x-axis, −log10(p-value) on the y-axis. The blue line indicates nominal p-values
LICENSING IN THE LIGHT OF ENVIRONMENTAL STATUS OF LAW
Creators: name: Lima, José Edmilson Souza
name: KARLLA MARIA MARTINI
Publisher: name: figshare
Year: 2014
Subjects: subject: Law
subject: FOS: Law

description: In a global and local scenario marked by the socio-environmental crisis, the Socio- environmental State of Rights erupts with the mission of protect and secure fundamental rights in all of their dimensions. In this context, this article aims to make visible how the environmental licensing may contribute to the accomplishment of this state’s new mission. To do so, it resorts to a literature research and concludes that, 381 under the legal perspective, the environmental licensing is a key instrument to reach the effectiveness of the most important mission of the Socio-environmental State of Rights, because if it gets “out of the paper” it can indeed help defining the contours of a new state and especially of a new civilization.
МУЗЫКАЛЬНО-ИСПОЛНИТЕЛЬСКОЕ ИСКУССТВО КОНЦА XIX – ПЕРВОЙ ПОЛОВИНЫ ХХ СТОЛЕТИЙ В КРИТИКО-ПУБЛИЦИСТИЧЕСКОМ НАСЛЕДИИ А. ОССОВСКОГО
Creators: name: Андриевская Галина Петровна
Publisher: name: Южно-Российский музыкальный альманах
Year: 2020
Subjects: А. Оссовский
музыкальная критика Серебряного века
музыкально-исполнительское искусство
исполнительская интерпретация.

description: Автор статьи обращается к критико-публицистическому наследию Александра Оссовского (1871–1957) – видного петербургского музыковеда-исследователя, организатора науки, педагога. Активная деятельность А. Оссовского в качестве музыкального критика (середина 1890-х – 1910-е годы) связана с эпохой Серебряного века русской культуры. Впечатляющая интенсивность тогдашней музыкальной жизни Петербурга, многообразие индивидуальных художественных исканий и перспективных тенденций предопределили особый интерес А. Оссовского-критика к современному композиторскому и исполнительскому творчеству. Освещение последнего в критических статьях А. Оссовского характеризуется в двух аспектах. Первый аспект подразумевает толкование социокультурного предназначения музыкального критика в качестве «летописца» значимых событий концертно-филармонического и музыкально-театрального процесса. Второй аспект соотносится с индивидуально трактуемыми фундаментальными категориями художественной интерпретации. Для А. Оссовского упомянутыми «первоосновами» музыкального исполнительства служат «концептуальность» (содержательность, обусловленная воплощением некой возвышенной идеи) и «интеллигентность» (оптимальное равновесие двух взаимодействующих аспектов – предзаданного авторского замысла и творящей воли артиста-интерпретатора). В статье констатируется определенное личное пристрастие А. Оссовского к исполнительским проблемам оперно-театрального искусства. Подобное отношение, вероятно, могло быть инспирировано синтетической природой оперного жанра, заведомо предоставляющего музыканту-исполнителю максимум выразительных средств и приемов. Помимо этого, А. Оссовский полагал несомненной прерогативой современного вокально-театрального искусства художественную репрезентацию глубинных истоков национального мироощущения. По мнению автора статьи, отмеченные «константы» музыкально-критического наследия А. Оссовского во многом предопределили тематику его позднейших научных исследований. Прослеживается и несомненная «эвристическая перспектива» упомянутых «констант» в последующей эволюции отечественной музыкальной критики.
A new phenylimidorhenium(V) compound containing the 2-[(2-hydroxyethylimino)methyl]phenol Schiff-base ligand: Experimental and theoretical aspects
Creators: name: Majumder, Smita
name: Jnan Prakash Naskar
name: Arnab Bhattacharya
name: Ganguly, Rakesh
name: Pinki Saha
name: Shubhamoy Chowdhury
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Chemistry
Earth and Environmental Sciences
Biotechnology
Cell Biology
Biochemistry

description: Reaction of equimolar trans-[Re(NPh)(PPh3)2Cl3] with H2L, a 1:1 Schiff-base condensate of salicylaldehyde and ethanolamine, in chloroform gives trans-[Re(NPh)(HL)(PPh3)Cl2] (1a) in good yield. 1a has been characterized by C, H and N microanalyses, FT-IR and UV-Vis spectra. The X-ray crystal structure of 1a reveals that it is an octahedral trans-Cl,Cl phenylimidorhenium(V) complex. The rhenium center has a ‘N2OCl2P’ coordination sphere. 1a crystallizes in the monoclinic space group P21/c with a = 11.2391(5), b = 16.4848(7), c = 16.3761(8) Å, V = 3034.0(2) Å3 and Z = 4. The electrochemical aspects of 1a have been studied. Electrochemical studies of 1a in dichloromethane show a quasi-reversible Re(V) to Re(VI) oxidation at 1.128 V versus Ag/AgCl. This redox potential reasonably matches the calculated redox potential, 1.186 V versus Ag/AgCl. Geometry optimization of the trans-Cl,Cl1a vis-à-vis its cis analogue, cis-Cl,Cl1b, have been performed at the level of density functional theory (DFT). It is revealed that 1a is more stable than 1b by 21.6 Kcal per mole of energy in the gas phase.
Additional file 15 of Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder
Creators: name: Czamara, Darina
name: Neufang, Alexa
name: Dieterle, Roman
name: Iurato, Stella
name: Arloth, Janine
name: Martins, Jade
name: Ising, Marcus
name: Binder, Elisabeth E.
name: Erhardt, Angelika
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 15: Figure S14. Scatterplots in PDI (above) and PDII (below) forF wigLuE on DNAm of cg20941758. The x-axis denotes log(wLE), the y-axis denotes M-value of cg20941758, PD cases are depicted in red, controls in green. The red line indicates the regression line in PD cases, the green line in controls.
ВЫРАЗИТЕЛЬНЫЕ ОСОБЕННОСТИ ТЕМБРО-ФАКТУРНЫХ ФОРМ В СОНОРНЫХ КОМПОЗИЦИЯХ С УЧАСТИЕМ СКРИПКИ
Creators: name: Кудашова Валентина Анатольевна
Publisher: name: Южно-Российский музыкальный альманах
Year: 2020
Subjects: сонорика
скрипка
тембро-фактурная форма
музыкальная ткань
колористические эффекты.

description: Сонорные сочинения для скрипки русских и зарубежных композиторов второй половины ХХ – начала XXI столетий отличает многообразие тембро-фактурных форм. Организация звукового материала в современных произведениях во многом зависит от композиционных техник письма, которые оказывают воздействие как на обновление качеств самого звука инструмента, так и на звукообраз скрипки в целом. Расширение тембро-акустических и колористических возможностей инструмента обусловливают новые фактурные формы изложения музыкального материала. В связи с этим на основе существующей теоретической систематики тембро-фактурных форм в статье исследуются сонорные музыкальные композиции с участием скрипки. Индивидуальные акустические и технические возможности инструмента определяют особенно яркое проявление тембро-сонорных эффектов. Их художественная специфика в значительной степени связана с исполнительскими приемами (способами звукоизвлечения и звуковедения), которые расширяют тембровые возможности скрипки. Современные авторы в скрипичных сочинениях применяют как специфические, так и неспецифические исполнительские приёмы: глиссандо (от одного до нескольких звуков, глиссандо к кластеру), тремоло, игра на подставке и за подставкой, удары по деке, pizzicato по струне сильным щелчком о гриф и др. Такие приёмы позволяют получить новые обертоновые, шумовые призвуки, которые значительно обогащают тембровую палитру звучания скрипки. Рассмотренные образцы скрипичных сочинений демонстрируют влияние тембро-фактурных форм на выражение тончайших нюансов и деталей содержания. Они, по сути, формируют представление о скрипичном звуке как о самодостаточном феномене, выполняющем в сочинениях важнейшую смысловую роль.
НЕТРАДИЦИОННЫЕ ПРИЕМЫ ИГРЫ НА ДУХОВЫХ ИНСТРУМЕНТАХ В ОТЕЧЕСТВЕННОЙ СПЕЦИАЛЬНОЙ ЛИТЕРАТУРЕ (статья 1)
Creators: name: Муединов Дилявер Меметович
Publisher: name: Южно-Российский музыкальный альманах
Year: 2020
Subjects: исполнительство на духовых инструментах
творческие инновации
нетрадиционные приемы игры
музыка для флейты 1950–2000-х годов.

description: Публикуемая статья посвящена инновационным процессам в исполнительстве на духовых инструментах второй половины ХХ столетия, представленным сквозь призму исследовательских наблюдений и оценок отечественных музыковедов, композиторов, музыкантов-практиков. Автором статьи отмечается, что проблема целенаправленного изучения и систематизации нетрадиционных приемов игры в указанной сфере исполнительства была осознана и с достаточной ясностью сформулирована специалистами к началу 1980-х годов. При этом обнаруживалось стремление к дифференцированному восприятию и многогранному постижению отмеченных приемов: с одной стороны, в аспекте драматургического и композиционного предназначения последних (Д. Н. Смирнов), с другой – исходя из перспективы расширения применяемого арсенала исполнительских средств выразительности (Б. Диков). Первая из вышеуказанных тенденций («композиторско-музыковедческая») характеризовалась преимущественным рассмотрением образно-смыслового «диапазона» каждого из нетрадиционных приемов, их «персонализованного» использования в современном художественном (прежде всего, концертном) репертуаре. Отсюда проистекали разнообразные отсылки к сочинениям зарубежных и отечественных композиторов, датируемым 1950-ми – началом 1980-х годов и репрезентирующим индивидуальные «толкования» упомянутых приемов. Вторая тенденция («методико-исполнительская») в большей мере тяготела к описанию технологических особенностей того или иного нетрадиционного приема, его вариантов, соответствующей систематики и т. п. Дальнейшее изучение этих приемов в отечественной специальной литературе, по мнению автора статьи, обусловливалось приоритетным влиянием одной из рассматриваемых тенденций. Обозначенный вывод наглядно подтверждается исследовательскими публикациями 2000–2010-х годов, обращенными к проблемам современного исполнительства на флейте (В. Давыдова, И. Вискова, И. Мутузкин, О. Танцов).
Additional file 14 of Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder
Creators: name: Czamara, Darina
name: Neufang, Alexa
name: Dieterle, Roman
name: Iurato, Stella
name: Arloth, Janine
name: Martins, Jade
name: Ising, Marcus
name: Binder, Elisabeth E.
name: Erhardt, Angelika
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 14: Figure S13. Manhattan plot for meta-analysis of EWAS of wLE x case-control-status in PDI and PDII. Chromosomal position is depicted on the x-axis, −log10(p-value) on the y-axis. The blue line indicates nominal p-values
Natural anti-A and Tn-cross-reactive IgM arise from developmental O-GalNAc glycosylations.*
Creators: name: Arend, Peter
Publisher: name: figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Hematology
subject: Medicine
subject: Biochemistry
subject: Developmental Biology
subject: Zoology
subject: 60114 Systems Biology
subject: Structural Biology
subject: Stem Cells
subject: Cell Biology
subject: Genetics

description: While native blood group A-like glycans have not been demonstrated in prokaryotic microorganisms as a source of human “natural” anti-A/B isoagglutinin production and the trans-species, vertebrate O-GalNAc-Ser/Thr glycosylations do not occur in bacteria, the O-GalNAc glycan-bearing ovarian glycolipids, discovered in C57BL/10 mice, are complementary to the syngeneic anti-A-reactive immunoglobulin M (IgM), which does not appear in animals that have undergone ovariectomy prior to the onset of puberty. This murine anti-A “auto” antibody and the human innate anti-A isoagglutinin, which is distinct from adaptive, cross-reactive anti-A/B reactivities, show identical serological reaction patterns. In mouse and man, this non-immune antibody molecule most likely obtains its complementarity from the early trans-species O-GalNAc glycosylation of proteins and subsequent GalNAc transferase depletion, which completes the cell differentiation processes and causes the release of characteristic O-glycan-depleted, complementary proteins, such as secretory IgM, which might reveal the structure of the volatilely expressed, “lost” glycan through germline-specific serine residues. Consequently, the early or first O-GalNAc glycosylations of proteins appear metabolically related to those of the mucin-type, “aberrant” monosaccharide GalNAcα1-O-Ser/Thr-R, also referred to as the Tn antigen, and explain the anti-Tn cross-reactivity of anti-A-specific immunoglobulins and the pronounced occurrence of cross-reactive anti-Tn antibody in plasma from humans with histo (blood) group O. In fact, in human blood group O, A-allelic, phenotype-specific GalNAc glycosylation of plasma proteins does not occur, affecting the levels of the anti-Tn antibody, which may function as a growth regulator that, depending on its levels, initiates a complex process of growth inhibition through enzyme-substrate competition with subsequent trans-species O-GalNAc-glycosylations.
Additional file 16 of Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder
Creators: name: Czamara, Darina
name: Neufang, Alexa
name: Dieterle, Roman
name: Iurato, Stella
name: Arloth, Janine
name: Martins, Jade
name: Ising, Marcus
name: Binder, Elisabeth E.
name: Erhardt, Angelika
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 16: Figure S15. Manhattan plot for EWAS of wLE in MDD cases. Chromosomal position is depicted on the x-axis, −log10(p-value) on the y-axis. The blue line indicates nominal p-values
Additional file 17 of Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder
Creators: name: Czamara, Darina
name: Neufang, Alexa
name: Dieterle, Roman
name: Iurato, Stella
name: Arloth, Janine
name: Martins, Jade
name: Ising, Marcus
name: Binder, Elisabeth E.
name: Erhardt, Angelika
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 17: Figure S16. Manhattan plot for meta-analysis of EWAS of wLE in PDI cases, PDII cases and MDD cases. Chromosomal position is depicted on the x-axis, −log10(p-value) on the y-axis. The blue line indicates nominal p-values <1.0 × 10−05 (A). QQ-plot for meta-analysis of EWAS of wLE in PDI cases, PDII cases and MDD cases cases depicting expected −log10(p-values) versus observed −log10(p-values). The lambda-value is 0.85 (B).
Additional file 18 of Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder
Creators: name: Czamara, Darina
name: Neufang, Alexa
name: Dieterle, Roman
name: Iurato, Stella
name: Arloth, Janine
name: Martins, Jade
name: Ising, Marcus
name: Binder, Elisabeth E.
name: Erhardt, Angelika
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 18: Figure S17. Scatterplots in PD discovery (above), PD replication (middle) and MDD sample (below) for wLE on DNAm of cg03341655. The x-axis denotes log(wLE), the y-axis denotes M-value of cg03341655. The black line indicates the regression line.
Natural anti-A and Tn-cross-reactive IgM arise from developmental O-GalNAc glycosylations.*
Creators: name: Arend, Peter
Publisher: name: figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Hematology
subject: Medicine
subject: Biochemistry
subject: Developmental Biology
subject: Zoology
subject: 60114 Systems Biology
subject: Structural Biology
subject: Stem Cells
subject: Cell Biology
subject: Genetics

description: While native blood group A-like glycans have not been demonstrated in prokaryotic microorganisms as a source of human “natural” anti-A/B isoagglutinin production and the trans-species, vertebrate O-GalNAc-Ser/Thr glycosylations do not occur in bacteria, the O-GalNAc glycan-bearing ovarian glycolipids, discovered in C57BL/10 mice, are complementary to the syngeneic anti-A-reactive immunoglobulin M (IgM), which does not appear in animals that have undergone ovariectomy prior to the onset of puberty. This murine anti-A “auto” antibody and the human innate anti-A isoagglutinin, which is distinct from adaptive, cross-reactive anti-A/B reactivities, show identical serological reaction patterns. In mouse and man, this non-immune antibody molecule most likely obtains its complementarity from the early trans-species O-GalNAc glycosylation of proteins and subsequent GalNAc transferase depletion, which completes the cell differentiation processes and causes the release of characteristic O-glycan-depleted, complementary proteins, such as secretory IgM, which might reveal the structure of the volatilely expressed, “lost” glycan through germline-specific serine residues. Consequently, the early or first O-GalNAc glycosylations of proteins appear metabolically related to those of the mucin-type, “aberrant” monosaccharide GalNAcα1-O-Ser/Thr-R, also referred to as the Tn antigen, and explain the anti-Tn cross-reactivity of anti-A-specific immunoglobulins and the pronounced occurrence of cross-reactive anti-Tn antibody in plasma from humans with histo (blood) group O. In fact, in human blood group O, A-allelic, phenotype-specific GalNAc glycosylation of plasma proteins does not occur, affecting the levels of the anti-Tn antibody, which may function as a growth regulator that, depending on its levels, initiates a complex process of growth inhibition through enzyme-substrate competition with subsequent trans-species O-GalNAc-glycosylations and the induction of a secondary immune response.
Additional file 1 of Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder
Creators: name: Czamara, Darina
name: Neufang, Alexa
name: Dieterle, Roman
name: Iurato, Stella
name: Arloth, Janine
name: Martins, Jade
name: Ising, Marcus
name: Binder, Elisabeth E.
name: Erhardt, Angelika
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Figure S1. Overview of conducted analyses.
Additional file 2 of Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder
Creators: name: Czamara, Darina
name: Neufang, Alexa
name: Dieterle, Roman
name: Iurato, Stella
name: Arloth, Janine
name: Martins, Jade
name: Ising, Marcus
name: Binder, Elisabeth E.
name: Erhardt, Angelika
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Figure S2. Manhattan plot for EWAS of wLE in PDI cases. Chromosomal position is depicted on the x-axis, −log10(p-value) on the y-axis. The blue line indicates nominal p-values
2 000 GACHA BO`LGAN EGIZAK TUB SONLAR
Creators: name: O'taganova Umida Egamberdi qizi, Termiz davlat pedagogika instituti Matematika va informatika fakulteti  Matematika va uni o'qitish metodikasi kafedrasi o'qituvchisi
Publisher: name: Zenodo
Year: 2024

description: Matematikaning  eng  qiziq  mavzularidan  biri  tub  sonlardir. Tub sonlar haqida ma`lumot, egizak tub sonlar va ikki mingacha bo`lgan tup sonlar ichidan egizak tup sonlar ko`rib chiqiladi.
Natural anti-A and Tn-cross-reactive IgM arise from developmental O-GalNAc glycosylations.*
Creators: name: Arend, Peter
Publisher: name: figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Hematology
subject: Medicine
subject: Biochemistry
subject: Developmental Biology
subject: Zoology
subject: 60114 Systems Biology
subject: Structural Biology
subject: Stem Cells
subject: Cell Biology
subject: Genetics

description: While native blood group A-like glycans have not been demonstrated in prokaryotic microorganisms as a source of human “natural” anti-A/B isoagglutinin production and the trans-species, vertebrate O-GalNAc-Ser/Thr glycosylations do not occur in bacteria, the O-GalNAc glycan-bearing ovarian glycolipids, discovered in C57BL/10 mice, are complementary to the syngeneic anti-A-reactive immunoglobulin M (IgM), which does not appear in animals that have undergone ovariectomy prior to the onset of puberty. This murine anti-A “auto” antibody, which is distinct from adaptive, cross-reactive anti-A/B reactivities, and the human innate anti-A isoagglutinin show identical serological reaction patterns. In mouse and man, this non-immune antibody molecule most likely obtains its complementarity from the early trans-species O-GalNAc glycosylation of proteins and subsequent GalNAc transferase depletion, which completes the cell differentiation processes and causes the release of characteristic O-glycan-depleted, complementary proteins, such as secretory IgM, which might reveal the structure of the volatilely expressed, “lost” glycan through germline-specific serine residues. Consequently, the early or first O-GalNAc glycosylations of proteins appear metabolically related to those of the mucin-type, “aberrant” monosaccharide GalNAcα1-O-Ser/Thr-R, also referred to as the Tn antigen, and explain the anti-Tn cross-reactivity of anti-A-specific immunoglobulins and the pronounced occurrence of cross-reactive anti-Tn antibody in plasma from humans with histo (blood) group O. In fact, in human blood group O, A-allelic, phenotype-specific GalNAc glycosylation of plasma proteins does not occur, affecting the levels of the anti-Tn antibody, which may function as a growth regulator that, depending on its levels, initiates a complex process of growth inhibition through enzyme-substrate competition with subsequent trans-species O-GalNAc-glycosylations.
Portraying the Perils to Polar Bears: The Role of Empathic and Objective Perspective-taking Toward Animals in Climate Change Communication
Creators: name: Swim, Janet K.
name: Bloodhart, Brittany
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences
subject: Neuroscience

description: Images of animals, particularly polar bears, harmed by climate change are often used in environmental campaigns, despite warnings of potential reactance and resultant perceived distance from the issue. As an alternative to these emotional appeals, environmental campaigns could encourage an objective (i.e., emotionally detached) perspective on climate change impacts. The present research tests the effects of a message that encourage empathic vs. objective perspectives toward polar bears harmed by climate change on emotions and subsequent support for climate change activism among 241 American adults through an online survey. Contrary to popular warnings, the present research found no reactance toward portraying harm to polar bears from climate change and no benefits of taking an objective perspective toward the polar bears. Instead, portrayals of polar bears harmed by climate change motivated both environmentalists and non-environmentalists to donate money to environmental activist groups when they took an empathic perspective toward the animals. Empathy and hope explain effects for environmentalists and empathy, hope, worry, personal guilt, and boredom explain effects for non-environmentalists.
Additional file 3 of Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder
Creators: name: Czamara, Darina
name: Neufang, Alexa
name: Dieterle, Roman
name: Iurato, Stella
name: Arloth, Janine
name: Martins, Jade
name: Ising, Marcus
name: Binder, Elisabeth E.
name: Erhardt, Angelika
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3: Figure S3. Manhattan plot for EWAS of wLE in PDII cases. Chromosomal position is depicted on the x-axis, −log10(p-value) on the y-axis. The blue line indicates nominal p-values
Y-Chromosomal Haplogroup R1b Diversity in Near East is Structured by Recent Historical Events
Creators: name: Maglio, Michael
Publisher: name: figshare
Year: 2014
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Anthropology
subject: FOS: Sociology

description: A number of Near East populations have been studied, leading to contradictory conclusions. Sampling processes, microsatellite count and recent historic events have the potential to distort the results. Standard practice for genetic sample selection is limited to validating the geographic origin of the subject’s father or grandfather. Restricting the sampling to 10 or 11 microsatellites allows for haplotype convergence and provides insufficient analytical value for nonbiased origin identification. Roman Catholic Crusader activity in the 11th–13th centuries introduced western European haplotypes into the Near East, complicating the sampling process. Theories of a Neolithic origin for haplogroup R1b will have to be re-evaluated.
Natural anti-A and Tn-cross-reactive IgM arise from developmental O-GalNAc glycosylations.*
Creators: name: Arend, Peter
Publisher: name: figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Hematology
subject: Medicine
subject: Biochemistry
subject: Developmental Biology
subject: Zoology
subject: 60114 Systems Biology
subject: Structural Biology
subject: Stem Cells
subject: Cell Biology
subject: Genetics

description: While native blood group A-like glycans have not been demonstrated in prokaryotic microorganisms as a source of human “natural” anti-A/B isoagglutinin production and the trans-species, eukaryotic O-GalNAc-Ser/Thr glycosylations do not occur in bacteria, the O-GalNAc glycan-bearing ovarian glycolipids, discovered in C57BL/10 mice, are complementary to the syngeneic anti-A-reactive immunoglobulin M (IgM), which does not appear in animals that have undergone ovariectomy prior to the onset of puberty. This murine anti-A “auto” antibody, which is distinct from adaptive, cross-reactive anti-A/B reactivities, and the human innate anti-A isoagglutinin show identical serological reaction patterns. In mouse and man, this non-immune antibody molecule most likely obtains its complementarity from the early trans-species O-GalNAc glycosylation of proteins and subsequent GalNAc transferase depletion, which completes the cell differentiation processes and causes the release of characteristic O-glycan-depleted, complementary proteins, such as secretory IgM, which might reveal the structure of the volatilely expressed, “lost” glycan through germline-specific serine residues. Consequently, the early or first O-GalNAc glycosylations of proteins appear metabolically related to those of the mucin-type, “aberrant” monosaccharide GalNAcα1-O-Ser/Thr-R, also referred to as the Tn antigen, and explain the anti-Tn cross-reactivity of anti-A-specific immunoglobulins and the pronounced occurrence of cross-reactive anti-Tn antibody in plasma from humans with histo (blood) group O. In fact, in human blood group O, A-allelic, phenotype-specific GalNAc glycosylation of plasma proteins does not occur, affecting the levels of the anti-Tn antibody, which may function as a growth regulator that, depending on its levels, initiates a complex process of growth inhibition through enzyme-substrate competition with subsequent trans-species O-GalNAc-glycosylations.
Natural anti-A and Tn-cross-reactive IgM arise from developmental O-GalNAc glycosylations.*
Creators: name: Arend, Peter
Publisher: name: figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Hematology
subject: Medicine
subject: Biochemistry
subject: Developmental Biology
subject: Zoology
subject: 60114 Systems Biology
subject: Structural Biology
subject: Stem Cells
subject: Cell Biology
subject: Genetics

description: While eukaryotic O-GalNAc-Ser/Thr glycosylations do not occur in bacteria, the O-GalNAc glycan-bearing ovarian glycolipids, discovered in C57BL/10 mice, are complementary to the syngeneic, anti-A-reactive immunoglobulin M (IgM), which does not appear in animals that have undergone ovariectomy prior to the onset of puberty. These murine ovarian glycolipids are also complementary to the Helix pomatia agglutinin, which has emerged from the protein coats of fertilized eggs of the snail and thus reveals the presence of functional snail O-GalNAc glycans.The hexameric structure of this lower eukaryotic, Helix pomatia agglutinin suggests evolutionary relationship to the mammalian non-immune IgM molecule, which hypothetically obtains its complementarity from the early trans-species O-GalNAc glycosylation of proteins and subsequent GalNAc transferase depletion that completes the cell differentiation processes and causes the release of O-glycan-depleted, complementary proteins, such as secretory IgM revealing the structure of the volatilely expressed, “lost” glycan carrier through germline-specific serine residues. Consequently, the early or first O-GalNAc glycosylations of proteins appear metabolically related to those of the mucin-type, “aberrant” monosaccharide GalNAcα1-O-Ser/Thr-R, also referred to as the Tn antigen, and explain the anti-Tn cross-reactivity of anti-A-specific immunoglobulins and the pronounced occurrence of cross-reactive anti-Tn antibody in plasma from humans with histo (blood) group O. In fact, in human blood group O, A-allelic, phenotype-specific GalNAc glycosylation of plasma proteins does not occur, affecting the levels of the anti-Tn antibody, which may function as a growth regulator that, depending on its levels, initiates a complex process of growth inhibition through enzyme-substrate competition with subsequent trans-species O-GalNAc-glycosylations.
title: Biochemical mechanisms of chloroquine uptake and resistance in malaria
Creators: name: Diribe, CO
Publisher: name: London School of Hygiene & Tropical Medicine
Year: 1981

description: Mechanisms of (14C) chloroquine accumulation and chloroquine resistance were studied in Plasmodium berghei (NK 65 and RC) in mouse erythrocytes in vitro. The quantity of chloroquine taken up by erythrocytes infected with the chloroquine resistant RC strain was similar to that found for the sensitive NK 65 strain when percentage of erythrocytes parasitised was taken into account. Chloroquine accumulation could be separated into saturable specific (high affinity), and an unsaturable non specific (low affinity) components. A specific receptor for chloroquine with a dissociation constant of 4.0 X 10-9 to 1.0 X 10-8 mol/l was found to be associated with uptake into erythrocytes infected with both NK 65 and RC, but was absent in uninfected erythrocytes or reticulocytes. This receptor was 6 times more abundant in erythrocytes infected with NK 65 strain than in those infected with RC - where non-specific uptake accounted for up to 80% of the total chloroquine accumulation. It was tentatively concluded that non-specific uptake was mainly related to chloroquine binding by erythrocyte macromolecules; whilst specific uptake was related to receptors associated with the parasite itself. Chloroquine uptake by NK 65 parasitised erythrocytes was highly dependent on glucose availability, which was not the case in uninfected erythrocytes. In parasitised erythrocytes, it seemed probable that only the specific component of uptake was dependent on D - glucose. The ionophores Monensin and Nigericin inhibited chloroquine uptake non-competitively in high sodium and potassium buffer5 respectively. This inhibition of uptake was achieved without significant changes in glycolytic rate. Partial alleviation by ouabain of the inhibitory effect of Monensin but not of Nigericin, suggested that the internal proton concentration of the erythrocyte compartment was involved in drug uptake. Valinomycin had much less effect indicating that membrane potential was a less important factor. Mean internal pH values of NK 65 and RC infected erythrocytes were found to be about 0.2 units lower than uninfected erythrocytes and 0.55 units lower than the plasma. It was concluded that chloroquine accumulation by P. berghei infected erythrocytes was dependent on several factors, but the basis of chloroquine resistance in RC strain was mainly a deficiency of specific receptor sites.
Additional file 4 of Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder
Creators: name: Czamara, Darina
name: Neufang, Alexa
name: Dieterle, Roman
name: Iurato, Stella
name: Arloth, Janine
name: Martins, Jade
name: Ising, Marcus
name: Binder, Elisabeth E.
name: Erhardt, Angelika
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 4: Figure S4. Manhattan plot for meta-analysis of EWAS of wLE in PDI cases and PDII cases. Chromosomal position is depicted on the x-axis, −log10(p-value) on the y-axis. The blue line indicates nominal p-values
Dynamic properties of the native free antithrombin from molecular dynamics simulations: computational evidence for solvent- exposed Arg393 side chain
Creators: name: Tóth, László
name: Fekete, Attila
name: Balogh, Gábor
name: Bereczky, Zsuzsanna
name: Komáromi, István
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Chemistry
Biotechnology
Cell Biology
Medicine
Physics
Biochemistry
Biophysics

description: While antithrombin (AT) has small basal inhibitory activity, it reaches its full inhibitory potential against activated blood coagulation factors, FXa, FIXa, and FIIa (thrombin), via an allosteric and/or template (bridging) mechanism by the action of heparin, heparan sulfate, or heparin-mimetic pentasaccharides (PS). From the numerous X-ray structures available for different conformational states of AT, only indirect and incomplete conclusions can be drawn on the inherently dynamic properties of AT. As a typical example, the basal inhibitory activity of AT cannot be interpreted on the basis of “non-activated” free antithrombin X-ray structures since the Arg393 side chain, playing crucial role in antithrombin-proteinase interaction, is not exposed. In order to reveal the intrinsic dynamic properties and the reason of basal inhibitory activity of antithrombin, 2 μs molecular dynamics simulations were carried out on its native free-forms. It was shown from the simulation trajectories that the reactive center loop which is functioning as “bait” for proteases, even without any biasing potential can populate conformational state in which the Arg393 side chain is solvent exposed. It is revealed from the trajectory analysis that the peptide sequences correspond to the helix D extension, and new helix P formation can be featured with especially large root-mean-square fluctuations. Mutual information analyses of the trajectory showed remarkable (generalized) correlation between those regions of antithrombin which changed their conformations as the consequence of AT–PS complex formation. This suggests that allosteric information propagation pathways are present even in the non-activated native form of AT.
Additional file 5 of Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder
Creators: name: Czamara, Darina
name: Neufang, Alexa
name: Dieterle, Roman
name: Iurato, Stella
name: Arloth, Janine
name: Martins, Jade
name: Ising, Marcus
name: Binder, Elisabeth E.
name: Erhardt, Angelika
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 5: Figure S5. Manhattan plot for EWAS of wposLE in PDI cases. Chromosomal position is depicted on the x-axis, −log10(p-value) on the y-axis. The blue line indicates nominal p-values
Additional file 6 of Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder
Creators: name: Czamara, Darina
name: Neufang, Alexa
name: Dieterle, Roman
name: Iurato, Stella
name: Arloth, Janine
name: Martins, Jade
name: Ising, Marcus
name: Binder, Elisabeth E.
name: Erhardt, Angelika
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 6: Figure S6. Manhattan plot for EWAS of wposLE in PDII cases. Chromosomal position is depicted on the x-axis, −log10(p-value) on the y-axis. The blue line indicates nominal p-values
Towards Applying Cryptographic Security Models to Real-World Systems
Creators: name: Rill, Jochen
Publisher: name: Karlsruhe
Year: 2020

description: The cryptographic methodology of formal security analysis usually works in three steps: choosing a security model, describing a system and its intended security properties, and creating a formal proof of security. For basic cryptographic primitives and simple protocols this is a well understood process and is performed regularly. For more complex systems, as they are in use in real-world settings it is rarely applied, however. In practice, this often leads to missing or incomplete descriptions of the security properties and requirements of such systems, which in turn can lead to insecure implementations and consequent security breaches. One of the main reasons for the lack of application of formal models in practice is that they are particularly difficult to use and to adapt to new use cases. With this work, we therefore aim to investigate how cryptographic security models can be used to argue about the security of real-world systems. To this end, we perform case studies of three important types of real-world systems: data outsourcing, computer networks and electronic payment. First, we give a unified framework to express and analyze the security of data outsourcing schemes. Within this framework, we define three privacy objectives: \emph{data privacy}, \emph{query privacy}, and \emph{result privacy}. We show that data privacy and query privacy are independent concepts, while result privacy is consequential to them. We then extend our framework to allow the modeling of \emph{integrity} for the specific use case of file systems. To validate our model, we show that existing security notions can be expressed within our framework and we prove the security of CryFS---a cryptographic cloud file system. Second, we introduce a model, based on the Universal Composability (UC) framework, in which computer networks and their security properties can be described We extend it to incorporate time, which cannot be expressed in the basic UC framework, and give formal tools to facilitate its application. For validation, we use this model to argue about the security of architectures of multiple firewalls in the presence of an active adversary. We show that a parallel composition of firewalls exhibits strictly better security properties than other variants. Finally, we introduce a formal model for the security of electronic payment protocols within the UC framework. Using this model, we prove a set of necessary requirements for secure electronic payment. Based on these findings, we discuss the security of current payment protocols and find that most are insecure. We then give a simple payment protocol inspired by chipTAN and photoTAN and prove its security within our model. We conclude that cryptographic security models can indeed be used to describe the security of real-world systems. They are, however, difficult to apply and always need to be adapted to the specific use case.
Natural anti-A and Tn-cross-reactive IgM arise from developmental O-GalNAc glycosylations.*
Creators: name: Arend, Peter
Publisher: name: figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Hematology
subject: Medicine
subject: Biochemistry
subject: Developmental Biology
subject: Zoology
subject: 60114 Systems Biology
subject: Structural Biology
subject: Stem Cells
subject: Cell Biology
subject: Genetics

description: While eukaryotic O-GalNAc-Ser/Thr glycosylations do not occur in bacteria, the O-GalNAc glycan-bearing ovarian glycolipids, discovered in C57BL/10 mice, are complementary to the syngeneic, anti-A-reactive immunoglobulin M (IgM), which does not appear in animals that have undergone ovariectomy prior to the onset of puberty. These mammalian ovarian glycolipids are also complementary to the anti-A/Tn-reactive Helix pomatia agglutinin, an eukaryotic defense protein, which has emerged from the coats of fertilized eggs and thus reveals the presence of functional snail O-GalNAc glycans. The hexameric structure of this lower eukaryotic, Helix pomatia agglutinin suggests evolutionary relationship to the mammalian non-immune IgM molecule, which hypothetically obtains its complementarity from the early trans-species O-GalNAc glycosylation of proteins and subsequent GalNAc transferase depletion that completes the cell differentiation processes and causes the release of O-glycan-depleted, complementary proteins, such as secretory IgM revealing the structure of the volatilely expressed, “lost” glycan carrier through germline-specific serine residues. Consequently, the early or first O-GalNAc glycosylations of proteins appear metabolically related to those of the mucin-type, “aberrant” monosaccharide GalNAcα1-O-Ser/Thr-R, also referred to as the Tn antigen, and explain the anti-Tn cross-reactivity of anti-A-specific immunoglobulins and the pronounced occurrence of cross-reactive anti-Tn antibody in plasma from humans with histo (blood) group O. In fact, in human blood group O, A-allelic, phenotype-specific GalNAc glycosylation of plasma proteins does not occur, affecting the levels of the anti-Tn antibody, which may function as a growth regulator that, depending on its levels, initiates a complex process of growth inhibition through enzyme-substrate competition with subsequent trans-species O-GalNAc-glycosylations.