cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Engraftment of human amniotic fluid stem cells (AFSCs) in calvarial bone of immunodeficient mice
Creators: name: Marchegiani, Francesco
name: Centurione, Lucia
name: Centurione, Maria Antonietta
name: Lichtler, Alexander
name: Kalajzic, Ivo
name: Di Pietro, Roberta
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2015
Subjects: AFSCs; transfection; Cherry red-fluorescent protein; bone defect.

description: AFSCs represent an attractive cell model for transplantation therapy due to the lack of significant immunogenicity, tumorigenicity and ethical issues (De Coppi et al., 2007). Although AFSCs have been investigated for bone repair, the cellular distribution and post-implantation viability remain key issues (Dupont et al., 2010). The present study was aimed at investigating whether AFSCs could improve bone healing in a calvarial defect model using immunodeficient mice. For this purpose AFSCs were transfected with a lentiviral vector expressing a ubiquitously directed red fluorescent protein-cherry. For in vivo experiments a critical size (3.5 mm) calvarial defect was developed in NOD scid gamma (NSG) immunodeficient mice. Human AFSCs were expanded in vitro and transfected at the 1st passage, then transplanted in vivo at the lesion sites after being loaded on HEALOS® scaffold (cross-linked collagen fibers fully coated with hydroxyapatite) appropriately shaped to cover the bone lesion. The calvarial defect was filled with the scaffold alone in control mice. Six weeks after implantation all animals were subjected to a skull X-ray before being sacrificed. Calvarial bone specimens were fixed in paraphormaldehyde, cryopreserved with sucrose and embedded in Cryomatrix TM resin. Sections were observed under fluorescence microscopy to detect the cherry-red signal, and then stained with haematoxylin-eosin solution to better analyze histological structures. Radiography scans of ex vivo bone explants demonstrated the presence of qualitatively and quantitatively mineralized tissue levels in the defect. Light microscopy observations revealed a major fibrous reaction in mice specimens treated with the scaffold supplemented with AFSCs compared with mice treated with the cell-free scaffold. The presence of cherry-positive AFSCs was recognized in the newly formed fibrous bone often around the scaffold and close to newly formed vessels. Our findings indicate that undifferentiated AFSCs seeded on a collagen scaffold can engraft in a host bone contributing to new bone and vessel formation. These preliminary observations pave the way to the use of new bioengineered constructs of stem cell–collagen scaffold for correcting large cranial defects in animal models and human subjects.
description: Italian Journal of Anatomy and Embryology, Vol 119, No 1 (Supplement) 2014
Singularities on the boundary of the stability domain near 1:1 resonance
Creators: name: Hoveijn, I.
name: Kirillov, O. N.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Dynamical Systems (math.DS)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Mathematical Physics (math-ph)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We study the linear differential equation x' = Lx in 1:1 resonance. That is, x in R^4 and L is a 4 by 4 matrix with a semi-simple double pair of imaginary eigenvalues (ib,-ib,ib,-ib). We wish to find all perturbations of this linear system such that the perturbed system is stable. Since linear differential equations are in one to one correspondence with linear maps we translate this problem to gl(4,R). In this setting our aim is to determine the stability domain and the singularities of its boundary. The dimension of gl(4,R) is 16, therefore we first reduce the dimension as far as possible. Here we use a versal unfolding of L ie a transverse section of the orbit of L under the adjoint action of Gl(4,R). Repeating a similar procedure in the versal unfolding we are able to reduce the dimension to 4. A 3-sphere in this 4-dimensional space contains all information about the neighborhood of L in gl(4,R). In this 3-sphere the boundary of the stability domain is a surface with singularities: transverse self-intersections, Whitney umbrellas and an intersection of self-intersections where the surface has a self-tangency.
description: 22 pages, 8 figures
A new method for switching off a mercury arc.
Creators: name: Fjarlie, Earl John
Publisher: name: University of British Columbia
Year: 2012

description: Continuous current control, so familiar in the operation of high-vacuum tubes, has not been possible, except under special circumstances, for gas tubes. Even current interruption has been awkward, except for low currents, for the usual manner of interrupting the current is to decrease the anode potential to zero. The time to switch off the gas tube has been of the order of the deionization time for the gas employed. Now a method is developed for switching off mercury-pool arcs using a third electrode. There is no interference with the main power circuit and, in fact, the potential on the anode causing the electric field aids the dispersal of the charge carriers when the arc has been interrupted. The switching-off time is much decreased because this anode-to-cathode voltage sweeps all the charge carriers out of the tube. Switching off is effected by passing a reverse current of equal or greater magnitude than the arc cathode current through the tube for a time long enough to interrupt the cathode spot. A technical difficulty arises in that the third electrode introducing the reverse current has to have an already formed or an easily formed cathode spot since this third electrode is a cold cathode. Many methods for forming the cathode spot are discussed. The method finally used is probably not the best one but it has the virtue of being easily effected. There appears to be no limit as to the current that can be interrupted if the spot-forming mechanism is altered. Energy used in not an important factor. The amount varies with the time to switch off and does not influence the actual switching process.
Hyphessobrycon stegemanni
Creators: name: Dagost, Fernando C. P.
name: Anoela M. F. Mar
name: Cila Cam
name: ávio C. T. Li
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Characiformes
Characidae
Hyphessobrycon
Hyphessobrycon stegemanni

description: Hyphessobrycon stegemanni: all from Rio Tocantins basin: MZUSP 83989, 16, 17.6–23.2 mm SL; MZUSP 113723, 21, 19.4–28.4 mm SL; MZUSP 113729, 15, 23.7–26.7 mm SL; MZUSP 113731, 2, 22.6–24.5 mm SL.
description: Published as part of Fernando C. P. Dagost, anoela M. F. Mar, cila Cam & ávio C. T. Li, 2016, A New Species of Hyphessobrycon (Characiformes: Characidae) from the Upper Rio Juruena Basin, Central Brazil, with a Redescription of H. cyanotaenia, pp. 250-259 in Copeia 104 (1) on page 258, DOI: 10.1643/Ci-15-243, http://zenodo.org/record/269576
Come ti illumino l’Universo primordiale
Creators: Elisa Nichelli
Publisher: name: Media Inaf
Year: 2015

Uno studio condotto da due ricercatori canadesi mostra come le stelle primordiali potrebbero essersi formate in gruppi ed aver attraversato un lungo periodo di attività, emettendo lampi luminosi con picchi fino a 100 milioni di volte la luminosità del Sole
title: Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð°ÑÑ Ð¸ÑÐµÐºÑÑÑÑ ÑÐ¸ÑÑÐ¾Ð²Ð¾Ð³Ð¾ Ð´Ð²Ð¾Ð¹Ð½Ð¸ÐºÐ° ÑÐµÐ½ÑÑÐ° Ð¡ÐÐ±ÐÐ£-Ð¤ÐÐ¡Ð¢Ð "Ð¡Ð¸Ð½ÐµÑÐ³Ð¸Ñ"
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
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Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2018
Subjects: ÐÐ½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½ÑÐµ ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸Ð¸
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ÐÑÐºÑÑÑÑÐ²ÐµÐ½Ð½ÑÐ¹ Ð¸Ð½ÑÐµÐ»Ð»ÐµÐºÑ

description: Ð¡ ÑÐ°Ð·Ð²Ð¸ÑÐ¸ÐµÐ¼ Ð¸ Ð¾Ð±ÑÐ¸ÑÐ½ÑÐ¼ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸ÐµÐ¼ Ð½Ð¾Ð²ÑÑ Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½ÑÑ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ð¹, ÐºÐ°Ðº Ð½Ð°Ð¿ÑÐ¸Ð¼ÐµÑ, Ð¾Ð±Ð»Ð°ÑÐ½ÑÐµ Ð²ÑÑÐ¸ÑÐ»ÐµÐ½Ð¸Ñ, Ð¸Ð½ÑÐµÑÐ½ÐµÑ Ð²ÐµÑÐµÐ¹, Bigdata Ð¸ Ð¸ÑÐºÑÑÑÑÐ²ÐµÐ½Ð½ÑÐ¹ Ð¸Ð½ÑÐµÐ»Ð»ÐµÐºÑ, Ð¿ÑÐ¸ÑÐ¾Ð´Ð¸Ñ Ð½Ð¾Ð²Ð°Ñ ÑÑÐ° Ð¸Ð½ÑÐµÐ»Ð»ÐµÐºÑÑÐ°Ð»ÑÐ½Ð¾Ð³Ð¾ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²Ð°. Ð ÑÐ¾ Ð¶Ðµ Ð²ÑÐµÐ¼Ñ, Ð¼Ð½Ð¾Ð³Ð¸Ðµ Ð³Ð¾ÑÑÐ´Ð°ÑÑÑÐ²ÐµÐ½Ð½ÑÐµ ÑÑÑÐ°ÑÐµÐ³Ð¸Ð¸ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²Ð° ÑÐµÐ°Ð»Ð¸Ð·ÑÑÑÑÑ Ð² Ð½Ð°ÑÑÐ¾ÑÑÐµÐµ Ð²ÑÐµÐ¼Ñ, ÐºÐ°Ðº Ð½Ð°Ð¿ÑÐ¸Ð¼ÐµÑ, ÐÐ½Ð´ÑÑÑÑÐ¸Ñ 4.0, ÐÑÐ¾Ð¼ÑÑÐ»ÐµÐ½Ð½ÑÐ¹ Ð¸Ð½ÑÐµÑÐ½ÐµÑ, Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²Ð¾ Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð½Ð¾Ðµ Ð½Ð° ÐºÐ¸Ð±ÐµÑ-ÑÐ¸Ð·Ð¸ÑÐµÑÐºÐ¸Ñ ÑÐ¸ÑÑÐµÐ¼Ð°Ñ, Madein Chinain 2025.
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Ð¢Ð°ÐºÐ¶Ðµ Ð² ÑÐ°Ð±Ð¾ÑÐµ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´Ð¸ÑÑÑ Ð°Ð½Ð°Ð»Ð¸Ð· Ð¸ÑÑÐ¾ÑÐ¸Ð¸ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ Digital twin Ñ ÑÐµÐ»ÑÑ Ð°ÑÐ³ÑÐ¼ÐµÐ½ÑÐ°ÑÐ¸Ð¸ Ð½ÐµÐ¾Ð±ÑÐ¾Ð´Ð¸Ð¼Ð¾ÑÑÐ¸ Ð²Ð²ÐµÐ´ÐµÐ½Ð¸Ñ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ð¸ Ð² ÑÐ¸ÑÐ¾ÐºÐ¾Ðµ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¸ Ð¾Ð¶Ð¸Ð´Ð°ÐµÐ¼ÑÐµ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ ÑÐ°ÐºÐ¾Ð³Ð¾ Ð²Ð½ÐµÐ´ÑÐµÐ½Ð¸Ñ. Ð Ð°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ñ Ð²Ð°ÑÐ¸Ð°Ð½ÑÑ Ð²Ð½ÐµÐ´ÑÐµÐ½Ð¸Ñ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ð¸ Ð¿Ð¾ ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ñ Digital Twin.
Probing the f(R) formalism through gravitational wave polarizations
Creators: name: Alves, Marcio E. S.
name: Miranda, Oswaldo D.
name: de Araujo, Jose C. N.
Publisher: name: arXiv
Year: 2009
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The direct observation of gravitational waves (GWs) in the near future, and the corresponding determination of the number of independent polarizations, is a powerful tool to test general relativity and alternative theories of gravity. In the present work we use the Newman-Penrose formalism to characterize GWs in quadratic gravity and in a particular class of f(R) Lagrangians. We find that both quadratic gravity and the f(R) theory belong to the most general invariant class of GWs, i.e., they can present up to six independent polarizations of GWs. For a particular combination of the parameters, we find that quadratic gravity can present up to five polarizations states. On the other hand, if we use the Palatini approach for f(R) theories, GWs present only the usual two transverse-traceless polarizations such as in general relativity. Thus, we conclude that the observation of GWs can strongly constrain the suitable formalism for these theories.
description: 18 pages, 1 figure, accepted for publication in Physics Letters B
La prima “luce visibile” di un esopianeta
Creators: Eleonora Ferroni
Publisher: name: Media Inaf
Year: 2015

51 Pegasi b è il primo esopianeta mai scoperto intorno a una stella simile al Sole. La nuova tecnica di osservazione sviluppata dai ricercatori avrà un brillante futuro, in particolare con l'avvento degli strumenti di nuova generazione, come EXPRESSO, sul VLT, e dei futuri telescopi come l'E-ELT
A parametric study of the meso-scale modelling of concrete subjected to cyclic compression
Creators: name: Rempling, Rasmus
name: Grassl, Peter
Publisher: name: arXiv
Year: 2008
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The present parametric study deals with the meso-scale modelling of concrete subjected to cyclic compression, which exhibits hysteresis loops during unloading and reloading. Concrete is idealised as a two-dimensional three-phase composite made of aggregates, mortar and interfacial transition zones (ITZs). The meso-scale modelling approach relies on the hypothesis that the hysteresis loops are caused by localised permanent displacements, which result in nonlinear fracture processes during unloading and reloading. A parametric study is carried out to investigate how aggregate density and size, amount of permanent displacements in the ITZ and the mortar, and the ITZ strength influence the hysteresis loops obtained with the meso-scale modelling approach.
Stronzio da record
Creators: Marco Malaspina
Publisher: name: Media Inaf
Year: 2015

Un orologio atomico 3 volte più preciso e del 50 percento più stabile rispetto al precedente primato è stato realizzato dai ricercatori del JILA, negli Stati Uniti, usando atomi di stronzio. Fra le possibili applicazioni, la geodesia relativistica di precisione. Lo studio su Nature Communications
Efficient and accurate calculation of exact exchange and RPA correlation energies in the Adiabatic-Connection Fluctuation-Dissipation theory
Creators: name: Nguyen, Huy-Viet
name: de Gironcoli, Stefano
Publisher: name: arXiv
Year: 2009
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Recently there has been a renewed interest in the calculation of exact-exchange and RPA correlation energies for realistic systems. These quantities are main ingredients of the so-called EXX/RPA+ scheme which has been shown to be a promising alternative approach to the standard LDA/GGA DFT for weakly bound systems where LDA and GGA perform poorly. In this paper, we present an efficient approach to compute the RPA correlation energy in the framework of the Adiabatic-Connection Fluctuation-Dissipation formalism. The method is based on the calculation of a relatively small number of eigenmodes of RPA dielectric matrix, efficiently computed by iterative density response calculations in the framework of Density Functional Perturbation Theory. We will also discuss a careful treatment of the integrable divergence in the exact-exchange energy calculation which alleviates the problem of its slow convergence with respect to Brillouin zone sampling. As an illustration of the method, we show the results of applications to bulk Si, Be dimer and atomic systems.
description: 12 pages, 6 figures. To appear in Phys. Rev. B
Cryopreservation influence in the WJCs Proteome
Creators: name: Marchisio, Marco
name: Pierdomenico, Laura
name: Lanuti, Paola
name: Ercolino, Eva
name: Bologna, Giuseppina
name: Grifone, Giovanna
name: Angelucci, Stefania
name: Di Ilio, Carmine
name: Miscia, Sebastiano
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2015
Subjects: Wharton’s jelly cells; Cryopreservation; Proteome analysis.

description: Cryopreservation is the only mode of long-term storage of viable cells and tissues for cellular therapy, stem cell transplantation and/or tissue engineering. However the freeze-thaw process strongly contributes to cell and tissue damage with several mechanism, including oxidative stress, intracellular ice formation (IIF) dependent cell injury and altered physical cellular properties, i.e. osmotic and ion homeostasis. Our previous proteomics investigation was carried on Wharton’s jelly cells (WJCs), fibroblastlike cells with similar properties to mesenchymal stem cells, therefore a rich source of primitive cells to be potentially used in regenerative medicine. The aim of the present work was to investigate molecular changes that occur in WJCs proteome at different culture conditions (freshly and post-frozen cell preparations) and to elucidate possible mechanism involved in maintaining active proliferation and maximal cellular plasticity in order to optimize in vitro culturing procedure. To analyze changes in protein expression of WJCs we performed a comparative proteomic analysis (2DE followed by MALDI–TOF MS) between fresh and post-frozen cell culturing. WJCs postfrozen showed a qualitative and quantitative changes compared to cells from fresh preparation, expressing proteins involved in replication, cellular defense mechanism and metabolism, that ensure freeze-thaw survival. However, further investigations are needed to clarify the biological mechanisms involved in maintaining active proliferation, plasticity, multipotency cell during in vitro expansion
description: Italian Journal of Anatomy and Embryology, Vol 119, No 1 (Supplement) 2014
Luce intermittente dalla oscura coppia
Creators: Marco Galliani
Publisher: name: Media Inaf
Year: 2015

Secondo un recente studio guidato da una giovane ricercatrice dell’Università del Maryland, la variazione periodica della luce emessa da un quasar sarebbe dovuta all’interazione di due buchi neri supermassicci. Data la loro vicinanza, questi oggetti celesti così estremi potrebbero anche emettere onde gravitazionali. Il commento di Tomaso Belloni (INAF)
Hsp60 Response in Experimental and Human Temporal Lobe Epilepsy due to hyppocampal sclerosis
Creators: name: Marino Gammazza, Antonella
name: Orban, Gergely
name: Pierucci, Massimo
name: Di Gennaro, Giancarlo
name: Lo Bello, Margherita
name: Colangeli, Roberto
name: D’Aniello, Alfredo
name: Bucchieri, Fabio
name: Pomara, Cristoforo
name: Benigno, Arcangelo
name: Farina, Felicia
name: De Macario, Everly Conway
name: Di Giovanni, Giuseppe
name: Macario, Alberto JL
name: Zummo, Giovanni
name: Cappello, Francesco
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2015
Subjects: Temporal lobe epilepsy; Hsp60; stress response; hippocampus.

description: Hsp60 is widely distributed in the brain, and its alteration has been involved in different neurological disorders. Epilepsy is considered one of the most common neurological disorders and typically involves the hippocampal formation. Compelling evidence describes a role of mitochondria, oxidative stress and both innate and adaptive immunity during epileptogenesis in temporal lobe epilepsy due to hyppocampal sclerosis (TLE-HS). Here, we investigate the Hsp60 involvement in experimental and human epilepsy. Firstly, expression and distribution of Hsp60 in epileptic hippocampi of a rat model of temporal lobe epilepsy (TLE), based on the phenomenon of maximal dentate gyrus activation (MDA), using western blotting and immunohistochemistry was evaluated. Moreover, the circulating levels of Hsp60 in the plasma derived from the blood of TLE-HS patients before and after epileptic seizure and agematched controls, using ELISA were investigated. Protein level and immunostaining of Hsp60 were increased in both the ipsilateral and contralateral hippocampi of the epileptic rats. The Hsp60 up-regulation was observed on neurons somata and neuropil of the dentate gyrus (DG) and in hippocampus proper (CA3, CA1). Moreover, Hsp60 plasmatic levels in patients after epilepitic seizure, compared to levels of the same subjects before seizure was significantly higher. These results demonstrate that Hsp60 synthesis is increased in response to epileptic seizures and could be used as a biomarker for hippocampal stress response in TLE-HS. In conclusion, our findings suggest that Hsp60 could play an importanty role in TLE-HS and support the possible involvement of immunological factors in epileptogenesis.
description: Italian Journal of Anatomy and Embryology, Vol 119, No 1 (Supplement) 2014
An upper limit to the central density of dark matter haloes from consistency with the presence of massive central black holes
Creators: name: Hernandez, X.
name: Lee, William H.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We study the growth rates of massive black holes in the centres of galaxies from accretion of dark matter from their surrounding haloes. By considering only the accretion due to dark matter particles on orbits unbound to the central black hole, we obtain a firm lower limit to the resulting accretion rate. We find that a runaway accretion regime occurs on a timescale which depends on the three characteristic parameters of the problem: the initial mass of the black hole, and the volume density and velocity dispersion of the dark matter particles in its vicinity. An analytical treatment of the accretion rate yields results implying that for the largest black hole masses inferred from QSO studies ($>10^{9} M_{\odot}$), the runaway regime would be reached on time scales which are shorter than the lifetimes of the haloes in question for central dark matter densities in excess of $250 M_{\odot}$pc$^{-3}$. Since reaching runaway accretion would strongly distort the host dark matter halo, the inferences of QSO black holes in this mass range lead to an upper limit on the central dark matter densities of their host haloes of $ρ_{0} < 250 M_{\odot} $pc$^{-3}$. This limit scales inversely with the assumed central black hole mass. However, thinking of dark matter profiles as universal across galactic populations, as cosmological studies imply, we obtain a firm upper limit for the central density of dark matter in such structures.
description: 5 pages, 2 figures, accepted as a letter in MNRAS
title: ÐÐ½Ð¾Ð³Ð¾ÑÑÐ°Ð¶Ð½Ð¾Ðµ Ð¶Ð¸Ð»Ð¾Ðµ Ð·Ð´Ð°Ð½Ð¸Ðµ Ñ ÑÑÑÑÐ¾Ð¹ÑÑÐ²Ð¾Ð¼ ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÐ½Ð¾Ð³Ð¾ Ð²Ð¾Ð´Ð¾Ð¿Ð¾Ð½Ð¸Ð¶ÐµÐ½Ð¸Ñ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
Creators: name: Ð¡Ð¼Ð¸ÑÐ½Ð¾Ð², ÐÐ³Ð¾Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2018
Subjects: Ð¶Ð¸Ð»Ð¾Ðµ Ð·Ð´Ð°Ð½Ð¸Ðµ
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description: Ð Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ¾Ð¹ Ð²ÑÐ¿ÑÑÐºÐ½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½ Ð¿ÑÐ¾ÐµÐºÑ Ð·Ð´Ð°Ð½Ð¸Ñ Ñ Ð¿Ð¾Ð´Ð·ÐµÐ¼Ð½Ð¾Ð¹ Ð°Ð²ÑÐ¾ÑÑÐ¾ÑÐ½ÐºÐ¾Ð¹, ÑÐ°ÑÐ¿Ð¾Ð»Ð°Ð³Ð°ÑÑÐµÐ³Ð¾ÑÑ Ð² Ð³Ð¾ÑÐ¾Ð´Ðµ Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ Ð½Ð° ÑÐ»Ð¸ÑÐµ ÐÐ¾ÑÐ°Ð±Ð»ÐµÑÑÑÐ¾Ð¸ÑÐµÐ»ÐµÐ¹. Ð ÑÐ¾ÑÑÐ°Ð² Ð¿ÑÐ¾ÐµÐºÑÐ°, ÑÐ¾Ð³Ð»Ð°ÑÐ½Ð¾ Ð·Ð°Ð´Ð°Ð½Ð¸Ñ Ð½Ð° Ð¿ÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ, Ð²ÑÐ¾Ð´ÑÑ Ð°ÑÑÐ¸ÑÐµÐºÑÑÑÐ½ÑÐµ Ð¸ Ð¾Ð±ÑÐµÐ¼Ð½Ð¾-Ð¿Ð»Ð°Ð½Ð¸ÑÐ¾Ð²Ð¾ÑÐ½ÑÐµ ÑÐµÑÐµÐ½Ð¸Ñ, Ð¿Ð»Ð°Ð½ Ð°ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¿Ð»Ð¸ÑÑ Ð¿ÐµÑÐµÐºÑÑÑÐ¸Ñ, ÐºÐ¾Ð»Ð¾Ð½Ð½ Ð¸ Ð¿Ð¸Ð»Ð¾Ð½Ð¾Ð², Ð¿ÑÐ¾ÐµÐºÑ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¸ ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÑÑÐ²Ð° Ñ ÐºÐ°Ð»ÐµÐ½Ð´Ð°ÑÐ½ÑÐ¼ Ð³ÑÐ°ÑÐ¸ÐºÐ¾Ð¼ ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÑÑÐ²Ð°, ÑÐµÐ¿Ð»Ð¾ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ°ÑÑÐµÑ Ð¾Ð³ÑÐ°Ð¶Ð´Ð°ÑÑÐ¸Ñ ÐºÐ¾Ð½ÑÑÑÑÐºÑÐ¸Ð¹. Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½ ÑÐ¸ÑÑÐ°ÑÐ¸Ð¾Ð½Ð½ÑÐ¹ Ð¿Ð»Ð°Ð½ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð·ÐµÐ¼ÐµÐ»ÑÐ½Ð¾Ð³Ð¾ ÑÑÐ°ÑÑÐºÐ°. Ð Ð²ÑÐ¿ÑÑÐºÐ½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ ÑÑÑÐµÐ½Ñ ÑÑÐµÐ±Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¿Ð¾ Ð¿Ð¾Ð¶Ð°ÑÐ½Ð¾Ð¹ Ð±ÐµÐ·Ð¾Ð¿Ð°ÑÐ½Ð¾ÑÑÐ¸, Ð¿Ð¾ Ð¾Ð±ÐµÑÐ¿ÐµÑÐµÐ½Ð¸Ñ Ð´Ð¾ÑÑÑÐ¿Ð° ÐÐÐ, Ð¿Ð¾ Ð¾ÑÑÐ°Ð½Ðµ Ð¾ÐºÑÑÐ¶Ð°ÑÑÐµÐ¹ ÑÑÐµÐ´Ñ. Ð ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ð¸ Ð·ÐµÐ¼Ð»ÑÐ½ÑÑ ÑÐ°Ð±Ð¾Ñ Ð¾ÑÐ¾Ð±Ð¾Ðµ Ð²Ð½Ð¸Ð¼Ð°Ð½Ð¸Ðµ ÑÐ´ÐµÐ»ÐµÐ½Ð¾ ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÐ½Ð¾Ð¼Ñ Ð²Ð¾Ð´Ð¾Ð¿Ð¾Ð½Ð¸Ð¶ÐµÐ½Ð¸Ñ, Ð½ÐµÐ¾Ð±ÑÐ¾Ð´Ð¸Ð¼Ð¾Ðµ Ð´Ð»Ñ Ð¿ÑÐµÐ´Ð¾ÑÐ²ÑÐ°ÑÐµÐ½Ð¸Ñ Ð·Ð°ÑÐ¾Ð¿Ð»ÐµÐ½Ð¸Ñ ÐºÐ¾ÑÐ»Ð¾Ð²Ð°Ð½Ð° Ð³ÑÑÐ½ÑÐ¾Ð²ÑÐ¼Ð¸ Ð²Ð¾Ð´Ð°Ð¼Ð¸. ÐÑÐµ ÑÐ°Ð·Ð´ÐµÐ»Ñ Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ¾Ð¹ Ð²ÑÐ¿ÑÑÐºÐ½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²ÑÑÑ ÑÑÐµÐ±Ð¾Ð²Ð°Ð½Ð¸ÑÐ¼ Ð´ÐµÐ¹ÑÑÐ²ÑÑÑÐ¸Ñ Ð½Ð¾ÑÐ¼Ð°ÑÐ¸Ð²Ð½ÑÑ Ð´Ð¾ÐºÑÐ¼ÐµÐ½ÑÐ¾Ð² Ð² ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÑÑÐ²Ðµ.
HDAC4 is necessary for satellite cell differentiation and muscle regeneration
Creators: name: Marroncelli, Nicoletta
name: Noviello, Chiara
name: Consalvi, Silvia
name: Saccone, Valentina
name: Puri, Pier Lorenzo
name: Olson, Eric N.
name: Adamo, Sergio
name: Moresi, Viviana
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2015
Subjects: Histone acetylation; chromatin remodeling; transcriptional regulation of gene expression; satellite cell commitment; muscle repair.

description: In response to injury, skeletal muscle exhibits high capacity to regenerate and epigenetics controls multiple steps of this process (Giordani et al., 2013). It has been demonstrated in vitro that completion of muscle differentiation requires shuttling of histone deacetylase 4 (HDAC4), a member of class IIa HDACs, from the nucleus to the cytoplasm and consequent activation of MEF2-dependent differentiation genes (McKinsey et al., 2000). In vivo, HDAC4 expression is up-regulated in skeletal muscle upon injury, suggesting a role for this protein in muscle regeneration. With the aim to elucidate the role of HDAC4 in skeletal muscle regeneration, we generate mice lacking HDAC4 in the satellite cells (HDAC4fl/fl;Pax7CE Cre). Lack of HDAC4 inhibits satellite cell differentiation. Despite having similar amount of sorted cells, HDAC4 KO satellite cells proliferate less and have less pax7 than controls. Importantly, muscle regeneration in vivo is impaired in HDAC4fl/fl;Pax7CE Cre mice. These results are confirmed by molecular analyses of the expression of myogenic markers. All together, these data delineate the importance of HDAC4 in muscle regeneration and suggest a protective role in response to muscle damage.
description: Italian Journal of Anatomy and Embryology, Vol 119, No 1 (Supplement) 2014
Risolto l’enigma della galassia Henize 2-10
Creators: Eleonora Ferroni
Publisher: name: Media Inaf
Year: 2015

Da tempo si parlava di questo misterioso buco nero trovato al centro della galassia a 30 milioni di luce da noi. Arrivano nuove conferme e con future osservazioni si potrà capire di più sulla nascita delle galassie nell'Universo primordiale
Hyphessobrycon vilmae
Creators: name: Dagost, Fernando C. P.
name: Anoela M. F. Mar
name: Cila Cam
name: ávio C. T. Li
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Characiformes
Characidae
Hyphessobrycon
Hyphessobrycon vilmae

description: Hyphessobrycon vilmae: INPA 16543, 3, 15.4–22.6 mm SL, INPA 16676, 1, 18.4 mm SL, INPA 16738, 518, 14.5–24.8 mm SL, INPA 16786, 1007, 17.6–27.6 mm SL, INPA 16824, 583, 16.6–27.5 mm SL, INPA 22936, 467, 17.5–27.5 mm SL, INPA 39167, 1, 20.1 mm SL, INPA 40966, 4, 19.4–19.7 mm SL, INPA 40975, 2, 20.8–24.3 mm SL, INPA 40986, 30, 12.8–21.2 mm SL, MZUSP 115740, 56, 15.2–24.3 mm SL, Rio Aripuanã basin; LBP 8004, 136, 13.9–22.6 mm SL, LBP 8011, 42, 16.2 – 20.0 mm SL, MZUSP 61128, 87, 14.2–25.7 mm SL, MZUSP 115814, 30, 14.8–23.8 mm SL, MZUSP 115892, 79, 13.5–19.1 mm SL, Rio Arinos basin; LBP 9030, 20, 16.3–22.4 mm SL, Rio Paraguay basin; MCP 30823, 9, 20.2–23.2 mm SL, MZUSP 91243, 21.4 mm SL, MZUSP 96034, 6, 16.4–22.1 mm SL, Rio Xingu basin; MCP 30831, 104, 17.2–26.7 mm SL, MCP 32343, 316, 19.2–22.9 mm SL, Rio Teles Pires basin.
description: Published as part of Fernando C. P. Dagost, anoela M. F. Mar, cila Cam & ávio C. T. Li, 2016, A New Species of Hyphessobrycon (Characiformes: Characidae) from the Upper Rio Juruena Basin, Central Brazil, with a Redescription of H. cyanotaenia, pp. 250-259 in Copeia 104 (1) on page 258, DOI: 10.1643/Ci-15-243, http://zenodo.org/record/269576
An integrator for a pulse-position-modulation analogue computer.
Creators: name: Larsen, Raymond Sverre
Publisher: name: University of British Columbia
Year: 2012

description: This thesis discusses the design of the basic circuits for an integrator for a pulse-position-modulation analogue computer. The computer operates on a time-sequential principle, utilizing a magnetic drum memory. In the integrator, pulse information from the drum is translated into a voltage by a sweep circuit. The information is integrated using pulse techniques and put back into pulse form to be rewritten on the magnetic drum. In the prototype integrator, the method of integration is a simple straight-line projection of the first derivative according to the equation y = (dy/dt)Δt. The integration will therefore have rather poor accuracy, but theoretically any desired accuracy can be achieved by simply extending the circuits developed in this thesis to include higher-order derivatives. Recommendations for the construction of a final prototype integrator are made at the end of the report. The circuits used are an ac-coupled sweep amplifier, an accurate voltage comparator, and standard flip-flops and gating circuits. Tests were performed which indicate the reliability of these circuits for accurate integration.
The distance to the C component of I Zw 18 and its star formation history: A probabilistic approach
Creators: name: Jamet, Luc
name: Cervino, Miguel
name: Luridiana, Valentina
name: Perez, Enrique
name: Yakobchuk, T.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We analyzed the resolved stellar population of the C component of the extremely metal-poor dwarf galaxy Izw18 in order to evaluate its distance and star formation history as accurately as possible. In particular, we aimed at answering the question of whether this stellar population is young. We developed a probabilistic approach to analyzing high-quality photometric data obtained with the Advanced Camera for Surveys of the Hubble Space Telescope. This approach gives a detailed account of the various stochastic aspects of star formation. We carried out two successive models of the stellar population of interest, paying attention to how our assumptions could affect the results. We found a distance to the C component of I Zw 18 as high as 27 Mpc, a significantly higher value than those cited in previous works. The star formation history we inferred from the observational data shows various interesting features: a strong starburst that lasted for about 15 Myr, a more moderate one that occurred approx 100 Myr ago, a continuous process of star formation between both starbursts, and a possible episode of low level star formation at ages over 100 Myr. The stellar population studied is likely approx 125 Myr old, although ages of a few Gyr cannot be ruled out. Furthermore, nearly all the stars were formed in the last few hundreds of Myr.
description: 13 pags., 17 (low-resolution) Figs. Accepted by A&A
Astronomi contro giardinieri (robot)
Creators: Marco Malaspina
Publisher: name: Media Inaf
Year: 2015

Il progetto di un sistema wireless per tosaerba robotici, sottoposto per approvazione alla FCC da parte della iRobot, preoccupa i radioastronomi in quanto possibile fonte d’interferenze. Pietro Bolli (INAF): “La banda richiesta è proprio quella legata all’emissione della riga del metanolo”
Signatures of the superfluid to Mott insulator transition in cold bosonic atoms in a one dimensional optical lattice
Creators: name: Ramanan, S.
name: Mishra, Tapan
name: Luthra, Meetu Sethi
name: Pai, Ramesh V.
name: Das, B. P.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We study the Bose-Hubbard model using the finite size density matrix renormalization group method. We obtain for the first time a complete phase diagram for a system in the presence of a harmonic trap and compare it with that of the homogeneous system. To realize the transition from the superfluid to the Mott insulator phase we investigate different experimental signatures of these phases in quantities such as momentum distribution, visibility, condensate fraction and the total number of bosons at a particular density. The relationships between the various experimental signatures and the phase diagram are highlighted.
description: 8 pages, 14 figures
Argonaute 2 as novel molecular determinant for myeloid differentiation
Creators: name: Masciarelli, Silvia
name: Iosue, Ilaria
name: Vico, Carmen
name: Bellissimo, Teresa
name: Colotti, Gianni
name: Padula, Fabrizio
name: Varchi, Greta
name: Del Rio, Alberto
name: Fazi, Francesco
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2015
Subjects: Argonaute 2; microRNA; myeloid differentiation.

description: microRNAs (miRNAs) are emerging as crucial factors for the establishment of complex regulatory circuitries involved in the regulation of hematopoietic cell fate determination. These small non-coding RNAs to exert their functional activity are assembled in RNA-induced silencing complexes (RISCs), where a member of Argonaute (Ago) family of proteins plays a central role in miRNA-mRNA target interaction and gene silencing. In human cells the miRNAs-Ago complex can also localize in the nucleus where Ago proteins can associate with promoter gene sequences to impact heterochromatin genomic structure and transcriptional silencing (Janowski BA et al., 2006; Meister G., 2013). By using human myeloid cell lines and acute myeloid leukemia (AML) primary blasts we highlight Ago2 as a new player in myeloid cell fate determination. We observed that: i) Ago2 protein levels are strongly increased during 1,25-dihydroxyvitamin D3 (D3)-induced monocyte differentiation, whereas are down-regulated during Retinoic Acid (RA)-induced granulocyte differentiation; ii) Ago2 depletion by shRNA or small chemical compounds disrupting both miRNA-Ago2 complex interaction and Ago2 chromatin localization, results in a strong improvement of the RA-dependent myeloid differentiation. These results are bringing out that the down-regulation of Ago2 expression/functional activity is required during RA-dependent myeloid differentiation and may represent a molecular determinant for the improvement of RA-treatment response in leukemic myeloid progenitors cells.
description: Italian Journal of Anatomy and Embryology, Vol 119, No 1 (Supplement) 2014
Classical Diffusion of a quantum particle in a noisy environment
Creators: name: Amir, Ariel
name: Lahini, Yoav
name: Perets, Hagai B.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Quantum Physics (quant-ph)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: We study the spreading of a quantum-mechanical wavepacket in a one-dimensional tight-binding model with a noisy potential, and analyze the emergence of classical diffusion from the quantum dynamics due to decoherence. We consider a finite correlation time of the noisy environment, and treat the system by utilizing the separation of fast (dephasing) and slow (diffusion) processes. We show that classical diffusive behavior emerges at long times, and we calculate analytically the dependence of the classical diffusion coefficient on the noise magnitude and correlation time. This method provides a general solution to this problem for arbitrary conditions of the noisy environment. The results are relevant to a large variety of physical systems, from electronic transport in solid state physics, to light transmission in optical devices, diffusion of excitons, and quantum computation.
Il re introverso
Creators: Marco Galliani
Publisher: name: Media Inaf
Year: 2015

Il satellite della NASA Swift ha colto un eccezionale lampo di emissione dal capostipite della classe delle Supergiant Fast X-ray Transients, durante il quale questa sorgente ha superato di ben 10 volte il proprio record personale di luminosità e persino il limite teorico massimo di luminosità atteso per queste sorgenti. Il risultato, ottenuto da un team in gran parte composto da ricercatori italiani e dell’INAF e guidato da Patrizia Romano (INAF-IASF di Palermo), solleva dubbi su alcuni aspetti fondamentali che riguardano queste imprevedibili sorgenti
Parkin isoforms expression in gliomas
Creators: name: Maugeri, G.
name: D’Amico, A.G.
name: Magro, G.
name: Salvatorelli, L.
name: Cavallaro, S.
name: Drago, F.
name: D’Agata, V.
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2015
Subjects: Parkin isoforms; glioma; tumor suppressor; mitophagy; proteasomal degradation.

description: Parkin (PARK2) is one of the largest genes in the human genome encoding for an E3 ubiquitin ligase. Its mutation is the cause of early-onset Parkinson’s disease, but recently it is linked to other pathologies including cancer. Parkin acts as a tumor suppressor. It displays a wide neuroprotective activity by promoting the removal of damaged mitochondria via mitophagy and increasing proteasomal degradation of toxic substrates. PARK2 primary transcript undergoes to an extensive alternative splicing, which enhances transcriptomic diversification and protein diversity in tissues and cells. To date, GenBank lists 26 human PARK2 transcripts corresponding to 21 different alternative splice variants. These transcripts show different expression patterns and encode for proteins with different functions, molecular weight and isoelectric point. Previous studies identified inactivating somatic mutations and frequent intragenic deletions of PARK2 in human cancers including gliomas (Veeriah et al., 2010). Recently, it has been demonstrated that Parkin pathway activation is predictive for the survival outcome of patients with glioma (Yeo et al., 2012). However, these papers focused on the expression of full length Parkin. In the present work we analyzed the expression pattern of Parkin isoforms in astrocytomas of different grade and we investigated their functions in a human glioblastoma multiforme cell line. Immunoblotting analysis by using two specific antibodies revealed that Parkin expression is generally higher in malignant glioblastoma than in less invasive astrocytomas, indicating a correlation between expression pattern of Parkin isoforms and tumor malignancy. Serum deprivation or treatment with a proteosome inhibitor MG132 or with carbonyl cyanide 3-chlorophenylhydrazone (CCCP), an uncoupling agent that dissipates the cells mitochondrial membrane potential, increased expression of 100-55-50 kDa parkin isoforms in glioma cells as compared to controls. These results, consistent with other studies, demonstrated a functional connection between Parkin expression, mitochondrial integrity and endoplasmic reticulum stress (Bouman et al., 2011). Parkin isoforms expression was also confirmed by confocal microscopy analysis. These results suggest that the characterization of some PARK2 isoforms may be usefull clinically to develop a prognostic tool in patients with brain tumor.
description: Italian Journal of Anatomy and Embryology, Vol 119, No 1 (Supplement) 2014
Bioarchaeological analysis of Castelsardo’s Mummies
Creators: name: Mazzarello, Vittorio
name: Chessa, Daniela
name: Delaconi, Paola
name: Marongiu, Patrizia
name: Kelvin, David J.
name: Kelvin, Nikky
name: Campus, Franco
name: Demurtas, Maria Antonietta
name: Sanna, Luca
name: Pomponi, Valeria
name: Serra, Rita
name: Bandiera, Pasquale
name: Montella, Andrea
name: Rubino, Salvatore
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2015
Subjects: Anthropology; Paleopatology; Histology; Immunohistochemestry; Bioarchaeology; Mummies.

description: In the early months of 2011, during the restoration of Sant’Antonio Abate’s Cathedral in Castelsardo came to light environments remained hidden so far, which aroused considerable interest both for the archaeological and anthropological point of view for the discovery of a cemetery crypt with numerous human remains dating from the eighteenth to nineteenth century. Archaeological investigations took place at different times and in different ways during the months of January to April of 2011, which allowed to detect a burial site, with a great number of individuals organized in several layers piled up at the bottom of the crypt, and to define some stages in the building of the church, mainly in its monumental transition from Romanesque structure to new cathedral seat of the diocese. Eighteen individuals of both sexes, were finally identified at different levels, including 16 partially mummified and 2 almost entirelly mummified deposited on a sort of open plank, that, from the archeological point of view, represented the crypt closing point. The found remains were studied in order to obtain interesting bioarchaeological information determining some peculiar characteristics regarding the medical and the scientific aspects, more precisely age of death, sex, stature in life, pathological conditions, and to evaluate the state of conservation of mummified tissues, describing the morphological characteristics by histological, immunohistochemical and ultrastructural techniques.
description: Italian Journal of Anatomy and Embryology, Vol 119, No 1 (Supplement) 2014
Dietary essential oil components in the prevention of hypoperfusion/reperfusion-induced tissue damage in the rat cerebral cortex
Creators: name: Melis, T.
name: Serra, M.P.
name: Boi, M.
name: Poddighe, L.
name: Picci, C.
name: Del Fiacco, M.
name: Carta, G.
name: Murru, E.
name: Lisai, S.
name: Sirigu, A.R.
name: Collu, M.
name: Banni, S.
name: Quartu, M.
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2015

description: To extend our previous observations on the beneficial effect of dietary Pistacia lentiscus L. essential oil during cerebral bilateral common carotid artery occlusioninduced injury, we evaluated the activity of one of its major components, beta-caryophyllene (BCP), already known to possess peculiar biological activities, in Wistar rat cerebral cortex. Cerebral hypoperfusion was produced by a 30 min bilateral common carotid artery occlusion followed by 60 min reperfusion (BCCAO/R). Animals were starved for 12 hours before surgery and, 6 hours prior to hypoperfusion, BCP (40 mg/kg/0, 45 ml of sunflower oil as vehicle) was administered via gavage. Biological samples of brain tissue, plasma and cerebrospinal fluid (CSF) were examined by HPLC, western blot, gel zymography and immunohistochemistry and analyzed for fatty acids, expression of the enzyme ciclooxygenase-2 (COX-2), CB receptors for endocannabinoids (eCBs), and peroxisome proliferator-activated receptor (PPAR)-alpha and enzymatic activity of matrix-metalloprotease-9 (MMP9). Data obtained indicate that BCP appears to influence the outcome of BCCAO/R cerebral injury by modulating changes in levels of polyunsaturated fatty acids, biosynthesis of eCBs and eCB congeners, expression of CB1 and CB2 receptors, COX-2 protein levels and enzymatic activity of MMP9. Brain tissue response to the hypoperfusion/reperfusion-induced cerebral insult is modulated by dietary administration of BCP, suggesting the possible use of this molecule as nutritional treatment in neuroprevention. Work funded by Fondazione Banco di Sardegna.
description: Italian Journal of Anatomy and Embryology, Vol 119, No 1 (Supplement) 2014
Role of NLRP3 in an experimental model of testicular ischemia and reperfusion in mice
Creators: name: Micali, Antonio
name: Pisani, Antonina
name: Arco, Alba Maria
name: Minutoli, Letteria
name: Antonuccio, Pietro
name: Romeo, Carmelo
name: Pizzino, Gabriele
name: Squadrito, Francesco
name: Altavilla, Domenica
name: Puzzolo, Domenico
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2015
Subjects: Inflammasome NLRP3; seminiferous tubules; ischemia/reperfusion; caspase-3; TUNEL

description: Inflammasomes are multi-protein complexes composed of one of several leucinerich repeat receptors (NLRs) including NLRP1, NLRP3, NLRC4 and AIM2: NLRP3 is currently the most fully characterized inflammasome. Testicular torsion leads to tissue degeneration and, after reperfusion, results in production of reactive oxygen species and triggers the apoptosis machinery. To better understand the role of NLRP3 during testicular ischemia/reperfusion (TI/R), we investigated the morphological aspects of spermatogenesis underlying the effects of inflammasome in KO mice during TI/R. KO (Nlrp3tm1bhk) and wild-type (WT: C57Bl6) animals underwent 1h testicular-ischemia followed by reperfusion. The mice were killed after 1 day and 7 days of reperfusion and the determination of caspase-3 activity was executed. Furthermore, both the tubular (mean seminiferous tubule diameter and Johnsen’s scoring system [1]) and extratubular (edema, hemorrhagic extravasation, vessels dilation, and Leydig cells changes [2]) compartments were evaluated. The TUNEL assay for apoptosis was also performed. After 1 and 7 days of reperfusion in WT mice an increase of caspase-3 was observed. Structurally, marked histological damages characterized by altered spermatogenesis, evident extratubular changes and increased TUNEL activity were observed. In KO mice caspase-3 was inhibited. Histological damages were significantly decreased, TUNEL activity was reduced and extratubular changes were significantly milder. We suggest that NLRP3 inhibition might have a protective role on spermatogenesis and it can be proposed in patients with unilateral testicular torsion.
description: Italian Journal of Anatomy and Embryology, Vol 119, No 1 (Supplement) 2014
Oxide superlattices with alternating p and n interfaces
Creators: name: Bristowe, N. C.
name: Artacho, Emilio
name: Littlewood, P. B.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: The physics of oxide superlattices is considered for pristine (001) multilayers of the band insulators LaAlO3 and SrTiO3 with alternating p and n interfaces. First principles results and a model of capacitor plates offer a simple paradigm to understand their dielectric properties and the insulator to metal transition (IMT) at interfaces with increasing layer thickness. The charge at insulating interfaces is found to be as predicted from the formal ionic charges, not populations. Different relative layer thicknesses produce a spontaneous polarization of the system, and allow manipulation of the interfacial electron gas. Large piezoresistance effects can be obtained from the sensitivity of the IMT to lateral strain. Carrier densities are found to be ideal for exciton condensation.
description: 5 pages, 4 pdf figures, 1 added figure and additional references and discussions
title: Fire Behaviour of NMC Li-ion Battery Cells
Creators: name: Russo, P.
name: Longobardo, G.
name: Mazzaro, M.
name: Di Bari, C.
name: Cancelliere, P.
name: International Seminar On Fire And Explosion Hazards (9; 2019; Saint Petersburg, Russia)
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2019

description: The main features of Lithium-ion (Li-ion) batteries are high energy and power density, which make this
storage technology suitable for portable electronics, power tools, and hybrid/full electric vehicles.
Moreover, during conditions that lead to failure, Li-ion battery cells could undergo into a process called
thermal runaway, which has resulted in numerous fire accidents. Thermal runaway implies a rapid
increase in battery cells temperature, accompanied by the release of flammable gases. These flammable
gases could be easily ignited by the batteryâs high temperature, resulting in a fire. In addition, the
combustion of these gases when venting from the battery poses another safety concern: the accumulation
and potential explosion of the gases themselves. Thermal runaway may also be responsible for
mechanical effects such as the projection of fragments as well as the release of toxic gases and vapours.
This study reports and discusses the results of fire tests performed on single Li-ion cells. Lithium Nickel
Manganese Cobalt oxides cells from Panasonic were used in the tests. The tests were carried out in a cone
calorimeter changing the state of charge of the cells and the radiant power of the conical heater. In order
to assess the ignition and combustion characteristics, ignition time, mass loss, heat release rate and
surface cell temperature were measured and recorded. The volatile organic compounds released during
the tests were also measured by a photoionization detector. Since the appropriate fire prevention and
protection measures have not yet been developed, this paper investigates the effects of thermal abuse
conditions on Li-ion cells of battery systems for hybrid/full electric vehicles, in order to develop safe
instructions and procedures for a rescue team that is called to respond to accidents involving these
vehicles.
Meno luci e più consapevolezza per l’IYL 2015
Creators: Eleonora Ferroni
Publisher: name: Media Inaf
Year: 2015

L'inquinamento luminoso del cielo notturno è ormai un fenomeno sempre più grave a cui l'UNESCO, la IAU e moltissime istituzioni, non solo scientifiche, in tutto il mondo cercano di porre rimedio, quantomeno sensibilizzando giovani e non addetti ai lavori sui danni del consumo energetico per la salute e per l'ambiente. Progetti ed eventi online e anche in Italia