cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Feasibility of a bilateral 4000–6000 Hz notch as a phenotype for genetic association analysis
Creators: name: Hauser, Elizabeth R.
name: Henrich, Vincent C.
name: Phillips, Susan L.
name: Richter, Scott J.
name: Teglas, Sandra L.
name: Ishan S. Bhatt
name: Morehouse, Robin C.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Developmental Biology
subject: Biological Sciences
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Genetics

description: Objective: Noise-induced hearing loss (NIHL) is a worldwide health problem and a growing concern among young people. Although some people appear to be more susceptible to NIHL, genetic association studies lack a specific phenotype. We tested the feasibility of a bilateral 4000–6000 Hz audiometric notch as a phenotype for identifying genetic contributions to hearing loss in young adults. Design: A case-control-control study was conducted to examine selected SNPs in 52 genes previously associated with hearing loss and/or expressed in the cochlea. A notch was defined as a minimum of a 15-dB drop at 4000–6000 Hz from the previous best threshold with a 5-dB ‘recovery’ at 8000 Hz. Study sample: Participants were 252 individuals of European descent taken from a population of 640 young adults who are students of classical music. Participants were grouped as No-notch (NN), Unilateral Notch (UN), or Bilateral Notch (BN). Results: The strongest evidence of a genetic association with the 4000–6000 Hz notch was a nonsynonymous SNP variant in the ESRR– gene (rs61742642:C> T, P386S). Carriers of the minor allele accounted for 26% of all bilateral losses. Conclusion: This study indicates that the 4000–6000 Hz bilateral notch is a feasible phenotype for identifying genetic susceptibility to hearing loss.
A new stochastic inner product core design for digital FIR filters
Creators: name: Wong, Ming Ming
name: Dennis Wong, M. L.
name: Zhang, Cishen
name: Hijazin, Ismat
Publisher: name: Swinburne
Year: 2024

description: Stochastic computing (SC) is a computational technique with computational operations governed by probability instead of arithmetic rules. It recently found promising applications in digital and image processing areas and attracted attentions of researchers. In this paper, a new stochastic inner product (multiply and accumulate) core with an improved scaling scheme is presented for improving the accuracy and fault tolerance performance of SC based finite impulse response (FIR) digital filters. The proposed inner product core is designed using tree structured multiplexers which is capable of reducing the critical path and fault propagation in the stochastic circuitry. The designed inner product core can lead to construction of SC based light weight and multiplierless FIR digital filters. As a result, an SC based FIR digital FIR filter is implemented on Altera Cyclone V FPGA which operates on stochastic sequences of 256-bits length (8-bits precision level). Experimental results show that the developed filter has lower hardware cost, better accuracy and higher fault tolerance level compared with other stochastic implementations.
Adult-children's perspectives on a parent's hearing impairment and its impact on their relationship and communication
Creators: name: Preminger, Jill E.
name: Montano, Joseph J.
name: Tjørnhøj-Thomsen, Tine
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology

description: Objective: The aim of the study was to describe third-party disability experienced by adult-children as a result of hearing impairment (HI) in a parent. Design: Using semi-structured interviews, participants were asked to describe the impact of a parent's HI on their relationship and communication. Interpretative phenomenological analysis, a qualitative method to explore participant's perceptions and viewpoints, was used as the method of analysis. Study sample: Twelve participants between the ages of 22 and 58 who each had a parent with confirmed HI who owned hearing aids. Results: Within the contextual factors of family relationships, communication situations, and the parent's personality, adult-children considered their coping strategies and feelings that arose as a result of the HI. Coping strategies included putting forth effort in communication, yelling as an ineffective communication strategy, and providing support to the parent with HI. The described feelings included frustration, uncertainty, and loss surrounding their communication and relationship with their parent with HI. These feelings arose as a result of implementing coping strategies, plus these feelings drove the employment of coping strategies. Conclusions: Adult-children of parents with HI experience third-party disability, however, the participation restrictions and activity limitations experienced by children appear less than experienced by spouses.
Measuring recall of medical information in non-English-speaking people with cancer: A methodology
Creators: name: Lipson-Smith, Ruby
name: Hyatt, Amelia
name: Murray, Alexandra
name: Butow, Phyllis
name: Hack, Thomas F.
name: Jefford, Michael
name: Ozolins, Uldis
name: Hale, Sandra
name: Schofield, Penelope
Publisher: name: Swinburne
Year: 2024

description: Background: Many patients who require an interpreter have difficulty remembering information from their medical consultations. Memory aids such as consultation audio-recordings may be of benefit to these patients. However, there is no established means of measuring patients' memory of medical information. Objectives: This study aimed to develop a method for eliciting and coding recall of medical information in non-English-speaking patients. Design: This method, called Patient-Interpreter-Clinician coding (PICcode), was developed in the context of a phase II trial conducted in two outpatient oncology clinics in Melbourne, Australia, and was refined iteratively through consultation with an expert panel and piloting. Between-coder differences in early versions of the coding system were resolved through discussion and consensus resulting in refinements to PICcode. Results: The final version of PICcode involved transcribing, translating and coding of audio-recorded consultations and semi-structured interviews (SSI). The SSIs were designed to elicit patients' free-recall of medical information. Every unit of medical information in the consultation was identified and categorized in a coding tree. SSIs were coded to identify the extent to which information was recalled from the consultation. Discussion: The iterative changes involved in developing PICcode assisted in clarifying precise details of the process and produced a widely applicable coding system. PICcode is the most comprehensively described method of determining the amount of information that patients who use an interpreter recall from their medical consultations. PICcode can be adapted for English-speaking patients and other healthcare populations.
English word frequency and recognition in bilinguals: Inter-corpus comparison and error analysis
Creators: name: Lu-Feng Shi
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Science Policy
subject: Biological Sciences

description: Objective: This study is the second of a two-part investigation on lexical effects on bilinguals’ performance on a clinical English word recognition test. Focus is on word-frequency effects using counts provided by four corpora. Design: Frequency of occurrence was obtained for 200 NU-6 words from the Hoosier mental lexicon (HML) and three contemporary corpora, American National Corpora, Hyperspace analogue to language (HAL), and SUBTLEXUS. Correlation analysis was performed between word frequency and error rate. Study sample: Ten monolinguals and 30 bilinguals participated. Bilinguals were further grouped according to their age of English acquisition and length of schooling/working in English. Results: Word frequency significantly affected word recognition in bilinguals who acquired English late and had limited schooling/working in English. When making errors, bilinguals tended to replace the target word with a word of a higher frequency. Overall, the newer corpora outperformed the HML in predicting error rate. Conclusions: Frequency counts provided by contemporary corpora predict bilinguals’ recognition of English monosyllabic words. Word frequency also helps explain top replacement words for misrecognized targets. Word-frequency effects are especially prominent for bilinguals foreign born and educated.
Hypothesis-based weight-of-evidence evaluation and risk assessment for naphthalene carcinogenesis
Creators: name: Bailey, Lisa A.
name: Nascarella, Marc A.
name: Kerper, Laura E.
name: Rhomberg, Lorenz R.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Science Policy
Cancer
Biological Sciences
Chemistry
Earth and Environmental Sciences
Pharmacology
Cell Biology
Medicine

description: Inhalation of naphthalene causes olfactory epithelial nasal tumors in rats (but not in mice) and benign lung adenomas in mice (but not in rats). The limited available human data have not identified an association between naphthalene exposure and increased respiratory cancer risk. Assessing naphthalene's carcinogenicity in humans, therefore, depends entirely on experimental evidence from rodents. We evaluated the respiratory carcinogenicity of naphthalene in rodents, and its potential relevance to humans, using our Hypothesis-Based Weight-of-Evidence (HBWoE) approach. We systematically and comparatively reviewed data relevant to key elements in the hypothesized modes of action (MoA) to determine which is best supported by the available data, allowing all of the data from each realm of investigation to inform interpretation of one another. Our analysis supports a mechanism that involves initial metabolism of naphthalene to the epoxide, followed by GSH depletion, cytotoxicity, chronic inflammation, regenerative hyperplasia, and tumor formation, with possible weak genotoxicity from downstream metabolites occurring only at high cytotoxic doses, strongly supporting a non-mutagenic threshold MoA in the rat nose. We also conducted a dose–response analysis, based on the likely MoA, which suggests that the rat nasal MoA is not relevant in human respiratory tissues at typical environmental exposures. Our analysis illustrates how a thorough WoE evaluation can be used to support a MoA, even when a mechanism of action cannot be fully elucidated. A non-mutagenic threshold MoA for naphthalene-induced rat nasal tumors should be considered as a basis to determine human relevance and to guide regulatory and risk-management decisions.
Utilizing Grounded SAM for self-supervised frugal camouflaged human detection
Creators: name: Pijarowski, Matthias
name: Wolpert, Alexander
name: Heckmann, Martin
name: Teutsch, Michael
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Visually detecting camouflaged objects is a hard problem for both humans and computer vision algorithms. Strong similarities between object and background appearance make the task significantly more challenging than traditional object detection or segmentation tasks. Current state-of-the-art models use either convolutional neural networks or vision transformers as feature extractors. They are trained in a fully supervised manner and thus need a large amount of labeled training data. In this paper, both self-supervised and frugal learning methods are introduced to the task of Camouflaged Object Detection (COD). The overall goal is to fine-tune two COD reference methods, namely SINet-V2 and HitNet, pre-trained for camouflaged animal detection to the task of camouflaged human detection. Therefore, we use the public dataset CPD1K that contains camouflaged humans in a forest environment. We create a strong baseline using supervised frugal transfer learning for the fine-tuning task. Then, we analyze three pseudo-labeling approaches to perform the fine-tuning task in a self-supervised manner. Our experiments show that we achieve similar performance by pure self-supervision compared to fully supervised frugal learning.
Hyperpolarized magnetic resonance spectroscopy for assessing tumor hypoxia
Creators: name: Iversen, Ane B.
name: Ringgaard, Steffen
name: Laustsen, Christoffer
name: Stødkilde-Jørgensen, Hans
name: Bentzen, Lise
name: Busk, Morten
name: Horsman, Michael R.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Physiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Cell Biology
subject: Medicine
subject: Engineering
subject: Biochemistry

description: Introduction. Hypoxic tumor cells are radioresistant, therefore, identification of hypoxia is crucial. Hyperpolarized magnetic resonance spectroscopy (HPMRS) allows real time measurements of the conversion of pyruvate to lactate, the final step of anaerobic energy production, and may thus allow non-invasive identification of hypoxia or treatment-induced changes in oxygenation. The aim of the study was to investigate the usefulness of HPMRS as a means to assess tumor hypoxia and its dynamics during intervention.Material and methods. C3H mammary carcinomas grown in CDF1 mice were used. To manipulate with tumor oxygenation, non-anaesthetized mice were gassed with air, 10% or 100% oxygen prior to administration of hyperpolarized [1-¹³C]pyruvate and HPMRS analysis. A direct assessment of tumor oxygen partial pressure (pO2) distributions were made using the Eppendorf oxygen electrode in a separate, but similarly treated, group of mice.Results. Even though breathing 100% oxygen improved tumor oxygenation as evidenced by pO2 measurements, the mean (with 1 S.E.) [1-¹³C]lactate/[1-¹³C]pyruvate ratio was unaffected by this intervention, being 34 (30–37) in mice breathing air and 37 (33–42) in mice breathing 100% oxygen. In contrast, and in accordance with pO2 measurements, a significant increase in the [1-¹³C]lactate/[1-¹³C]pyruvate ratio was seen in 10% oxygen-breathing mice with a ratio of 46 (42–50).Conclusions. Although, no metabolic change was observed during 100% O2 breathing using HPMRS, the significant increase in the [1-¹³C]lactate/[1-¹³C]pyruvate ratio during 10% oxygen breathing suggests, that HPMRS can detect hypoxia-driven changes in the metabolic fate of pyruvate. To what extent and for what purposes HPMRS may best supplement or complement established techniques like hypoxia PET needs to be unraveled in future research.
Force Majeure Clauses: What Are They and Do They Apply in Issues Caused by COVID19?
Creators: name: Goeringer, Paul
name: Thilmany, Elizabeth
name: Suri, Mayhah
Publisher: name: Digital Repository at the University of Maryland
Year: 2020
Subjects: force majeure
contract
COVID
COVID-19
agricultural law

description: 2020 has been a challenging year with the global economic shutdown from COVID-19 leading to disruptions in many industries. Agriculture has had its fair share of disruptions from this global pandemic. Such disruptions have raised questions for many of you about your contracts to supply farm products to businesses, such as restaurants or schools, that no longer need those products due to shutdowns. You may also have issues finding labor to help move products to customers. Contracts between suppliers and customers often include provisions called force majeure clauses. These clauses allow one or both parties in a contract to excuse the performance, in this case, the fulfillment, of the contract in certain situations.
description: 2020 has been a challenging year with the global economic shutdown from COVID-19 leading to disruptions in many industries. Agriculture has had its fair share of disruptions from this global pandemic. Such disruptions have raised questions for many of you about your contracts to supply farm products to businesses, such as restaurants or schools, that no longer need those products due to shutdowns. You may also have issues finding labor to help move products to customers. Contracts between suppliers and customers often include provisions called force majeure clauses. These clauses allow one or both parties in a contract to excuse the performance, in this case, the fulfillment, of the contract in certain situations.
Evaluation of anticoagulant activity of two algal polysaccharides
Creators: name: C. Faggio
name: M. Pagano
name: A. Dottore
name: G. Genovese
name: M. Morabito
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Inorganic Chemistry
subject: Hematology
subject: Plant Biology

description: Marine algae are important sources of phycocolloids like agar, carrageenans and alginates used in industrial applications. Algal polysaccharides have emerged as an important class of bioactive products showing interesting properties. The aim of our study was to evaluate the potential uses as anticoagulant drugs of algal sulphate polysaccharides extracted from Ulva fasciata (Chlorophyta) and Agardhiella subulata (Rhodophyta) collected in Ganzirri Lake (Cape Peloro Lagoon, north-eastern Sicily, Italy). Toxicity of algal extracts through trypan blue test and anticoagulant action measured by activated partial thromboplastin time (APTT), prothrombin time (PT) test has been evaluated. Algal extracts showed to prolong the PT and APTT during the coagulation cascade and to avoid the blood coagulation of samples. Furthermore, the algal extracts lack toxic effects towards cellular metabolism and their productions are relatively at low cost. This permits to consider the algae as the biological source of the future.
Building Bonding and Bridging Capital through the ‘China Club’
Creators: name: Santoro, Ninetta
name: Cassidy, Claire
name: MacDonald, Craig
Publisher: name: Swinburne
Year: 2024

description: Out-of-school activities offered to young people can be discrete activities, completely divorced from school life and school curriculum, or they can offer extensions to normal school curriculum. This article reports on an ethnographic case study that investigated the effectiveness of a particular out-of-school activity, the ‘China Club’. It offered secondary school pupils in the West of Scotland opportunities to learn about Mandarin language and Chinese culture, and facilitated the development of Bonding Capital between the group members and Bridging Capital between individual group members and people outwith the group. In working with those with whom they would not normally have engaged, and in visiting China as part of the ‘China Club’, the young people’s peer relationships were positively impacted upon, as was their willingness to take risks by moving beyond familiar and predictable social and learning environments to those that challenged and tested them, socially, and as learners.
Replication package for analysis reported in "The Link Between Social-Ecological Network Fit and Outcomes: A Rare Empirical Assessment of a Prominent Hypothesis" by Martin Huber, Mario Angst and Manuel Fischer (2024)
Creators: name: Angst, Mario
Publisher: name: Zenodo
Year: 2025

description: This replication package replicates the analysis reported in:

Huber, M. N., Angst, M., & Fischer, M. (2024). The Link Between Social-Ecological Network Fit and Outcomes: A Rare Empirical Assessment of a Prominent Hypothesis. Society & Natural Resources, 37(7), 1090–1107. https://doi.org/10.1080/08941920.2024.2335393

See README.md for detailed instructions.
Identifying Features of Fitness Landscapes and Relating Them to Problem Difficulty
Creators: name: Moser, Irene
name: Gheorghita, M.
name: Aleti, A.
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 460203
subject: Evolutionary computation

description: Complex combinatorial problems are most often optimised with heuristic solvers which usually deliver acceptable results without any indication of the quality obtained. Recently, Predictive Diagnostic Optimisation was proposed as a means of characterising the fitness landscape while optimising a combinatorial problem. The scalars produced by Predictive Diagnostic Optimisation appeared to describe the difficulty of the problem with relative reliability. In this study, we record more scalars that may be helpful in determining problem difficulty during the optimisation process and analyse these in combination with other well-known landscape descriptors using exploratory factor analysis on four landscapes that arise from different search operators, applied to a varied set of quadratic assignment problem instances. Factors are designed to capture properties by combining the collinear variances of several variables. The extracted factors can be interpreted as features of landscapes detected by the variables, but disappoint in their weak correlationswith the result quality achieved by the optimiser, which we regard as the most reliable indicator of difficulty available. It appears that only the prediction error of Predictive Diagnostic Optimisation has a strong correlation with the quality of the results produced, followed by a medium correlation of the fitness distance correlation of the local optima.
A new Eocene lineage of reticulate Nummulites (Foraminifera) from Kilwa district, Tanzania; a place for Nummulites ptukhiani?
Creators: name: Cotton, Laura J.
name: Pearson, Paul N.
name: Renema, Willem
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences
subject: Evolutionary Biology
subject: Pharmacology
subject: Cell Biology

description: Reticulate Nummulites are a widespread and distinctive group of Nummulites, frequently used in biostratigraphy, but their evolution is poorly understood. Studies from the Western Tethys suggest they form a single lineage, the Nummulites fabianii lineage, with an increasing proloculus size over time. This has led to their use as one of the diagnostic taxa for larger benthic foraminiferal biostratigraphy. However, outside of this region, additional taxa have been recorded. The most widely discussed example is Nummulites ptukhiani, which was described from Armenia, whose morphology does not fit with the N. fabianii lineage. This raises the question whether reticulate Nummulites are monophyletic, or the result of multiple independent convergent evolutionary lineages. Here we present data from three newly identified populations of Lutetian to Bartonian reticulate Nummulites from the stratigraphically well-constrained Tanzania Drilling Project records, which shed new light on the ancestry of these aberrant forms. These populations are characterized by extremely large proloculi and unusual morphology. We demonstrate that the populations are consistent with an evolutionary lineage that is morphologically distinct but contemporaneous with the N. fabianii lineage of the Tethys. These forms are remarkably similar in external and internal morphology to the Armenian Nummulites ptukhiani. We therefore refer to them as the N. ptukhiani lineage. The existence of a second lineage of reticulate Nummulites indicates that their evolution is more complex than previously thought and raises questions as to whether they evolved from a common ancestor, or independently. It also underlines the importance of carrying out thorough studies of larger benthic foraminifera with independent stratigraphical control from outside of the Tethyan region to more fully understand their evolution and to enable accurate biostratigraphy.
Regulatory dynamics of network architecture and function in tristable genetic circuit of Leishmania: a mathematical biology approach
Creators: name: Vineetha Mandlik
name: Mayuri Gurav
name: Shailza Singh
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Developmental Biology
subject: Biological Sciences
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Microbiology
subject: Physics
subject: Biochemistry

description: The emerging field of synthetic biology has led to the design of tailor-made synthetic circuits for several therapeutic applications. Biological networks can be reprogramed by designing synthetic circuits that modulate the expression of target proteins. IPCS (inositol phosphorylceramide synthase) has been an attractive target in the sphingolipid metabolism of the parasite Leishmania. In this study, we have constructed a tristable circuit for the IPCS protein. The circuit has been validated and its long-term behavior has been assessed. The robustness and evolvability of the circuit has been estimated using evolutionary algorithms. The tristable synthetic circuit has been specifically designed to improve the rate of production of phosphatidylcholine: ceramide cholinephosphotransferase 4 (SLS4 protein). Site-specific delivery of the circuit into the parasite-infected macrophages could serve as a possible therapeutic intervention of the infectious disease ‘Leishmaniasis’.
The generalized Kudryashov method to obtain exact traveling wave solutions of the PHI-four equation and the Fisher equation
Creators: name: Mahmud, Forhad
name: Samsuzzoha, Md
name: Akbar, M. Ali
Publisher: name: Swinburne
Year: 2024

description: In recent years, searching exact traveling wave solutions to nonlinear evolution equations (NLEEs) has become a remarkable topic of research. In this article, we obtain exact traveling wave solutions of two significant NLEEs, namely, the PHI-four equation and the Fisher equation involving parameters by using the generalized Kudryashov method. We attain some exponential type solutions including kink soliton, bisymmetry soliton, and periodic solution when the parameters receive different values. We provide the graphical representations of the respective solutions also.
β-Cyclodextrin in Water: Highly Versatile and Green Approach for Biomimetic Regioselective Ring Opening of Chalcone Epoxides with Nitrogen Heterocycles
Creators: name: Kumar, Sumit
name: Konduru, Naveen Kumar
name: Nishant Verma
name: Ahmed, Naseem
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Chemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Biochemistry

description: The formation of new C-C bond through highly regioselective ring opening of chalcone epoxides to nitrogen-containing heterocycles has been effectively worked out in impressive yields with heterocyclic nucleophiles such as pyrrole, indole, and 2-methyl indole in the presence of β-cyclodextrin using water as solvent at room temperature within 25–50 min. Water, an environmentally friendly reaction medium, has been utilized for the first time for the reaction of these heterocyclic nucleophiles with chalcone epoxides as their β-cyclodextrin complexes to afford 1,3-diaryl-2-hydroxy-3-(1H-3-indolyl/2-pyrrolyl)propan-1-ones (3a–u). The catalyst can be easily recovered and recycled for several times without loss of activity.
PREFACE
Creators: name: Kin-Tak Lau, Alan
name: Tsai, Pei-Wei
name: Watada, Junzo
name: Jain, Lakhmi C.
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 4602
subject: Artificial intelligence
classificationCode: 460403
subject: Data security and protection
classificationCode: 460405
subject: Hardware security
classificationCode: 460406
subject: Software and application security
classificationCode: 460407
subject: System and network security
classificationCode: 4609
subject: Information systems

description: Abstract not available.
Evaluation of anticoagulant activity of two algal polysaccharides
Creators: name: C. Faggio
name: M. Pagano
name: A. Dottore
name: G. Genovese
name: M. Morabito
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Hematology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Ecology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Genetics
subject: Cell Biology
subject: Biochemistry

description: Marine algae are important sources of phycocolloids like agar, carrageenans and alginates used in industrial applications. Algal polysaccharides have emerged as an important class of bioactive products showing interesting properties. The aim of our study was to evaluate the potential uses as anticoagulant drugs of algal sulphate polysaccharides extracted from Ulva fasciata (Chlorophyta) and Agardhiella subulata (Rhodophyta) collected in Ganzirri Lake (Cape Peloro Lagoon, north-eastern Sicily, Italy). Toxicity of algal extracts through trypan blue test and anticoagulant action measured by activated partial thromboplastin time (APTT), prothrombin time (PT) test has been evaluated. Algal extracts showed to prolong the PT and APTT during the coagulation cascade and to avoid the blood coagulation of samples. Furthermore, the algal extracts lack toxic effects towards cellular metabolism and their productions are relatively at low cost. This permits to consider the algae as the biological source of the future.
I was Sick and Had Family Issues- Cynthia Morgan Reveals Why She' was out of Spotlight
Creators: name: Seo, Prince
Publisher: name: Zenodo
Year: 2020
Subjects: Cynthia Morgan Reveals Why She' was out of Spotlight

description: Nigerian dance hall star, Madrina, formerly known as Cynthia Morgan has finally revealed why she disappeared from the spotlight. Recall the Edo State-born artiste first took a year break in 2017 before making a comeback the following year to reveal she had changed her stage name to Madrina. Few months later, the 'German Juice' crooner deleted her Instagram account and disappeared from the spotlight. The singer has now disclosed in a recent interview on Lunchtime Friday With Sydney Shocker, the reasons behind her disappearance. According to Madrina, she was really sick and was facing a lot of family issues which gave her a breakdown to continue with her musical career.
Regulatory dynamics of network architecture and function in Tristable genetic circuit of Leishmania: A Mathematical biology Approach
Creators: name: Vineetha Mandlik
name: Mayuri Gurav
name: Shailza Singh
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Developmental Biology
subject: Biological Sciences
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Microbiology
subject: Physics
subject: Biochemistry

description: The emerging field of synthetic biology has led to the design of tailor-made synthetic circuits for several therapeutic applications. Biological networks can be re-programmed by designing synthetic circuits that modulate the expression of target proteins. IPCS (Inositol phosphorylceramide synthase) has been an attractive target in the sphingolipid metabolism of the parasite ‘Leishmania’. In the present study, we have constructed a tristable circuit for the IPCS protein. The circuit has been validated and its long term behaviour has been assessed. The robustness and evolvability of the circuit has been estimated by using evolutionary algorithms. The tristable synthetic circuit has been specifically designed to improve the rate of production of Phosphatidylcholine: ceramide cholinephosphotransferase 4 (SLS4 protein). Site specific delivery of the circuit into the parasite infected macrophages could serve as a possible therapeutic intervention of the infectious disease ‘Leishmaniasis’.
An in silico approach towards the identification of novel inhibitors of the TLR-4 signaling pathway
Creators: name: Jarjapu Mahita
name: K. Harini
name: Mallikarjuna Rao Pichika
name: Sowdhamini, Ramanathan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Precise functioning and fine-tuning of Toll-like receptor 4 (TLR4) signaling is a critical requirement for the smooth functioning of the innate immune system, since aberrant TLR4 activation causes excessive production of pro-inflammatory cytokines and interferons. This can result in life threatening conditions such as septic shock and other inflammatory disorders. The TRIF-related adaptor molecule (TRAM) adaptor protein is unique to the TLR4 signaling pathway and abrogation of TRAM-mediated TLR4 signaling is a promising strategy for developing therapeutics aimed at disrupting TRAM interactions with other components of the TLR4 signaling complex. The VIPER motif from the vaccinia virus-producing protein, A46 has been reported to disrupt TRAM-TLR4 interactions. We have exploited this information, in combination with homology modeling and docking approaches, to identify a potential binding site on TRAM lined by the BB loop and αC helix. Virtual screening of commercially available small molecules targeting the binding site enabled to short-list 12 small molecules to abrogate TRAM-mediated TLR4 signaling. Molecular dynamics and molecular mechanics calculations have been performed for the analysis of these receptor-ligand interactions.
β-Cyclodextrin in Water: Highly Versatile and Green Approach for Biomimetic Regioselective Ring Opening of Chalcone Epoxides with Nitrogen Heterocycles
Creators: name: Kumar, Sumit
name: Konduru, Naveen Kumar
name: Nishant Verma
name: Ahmed, Naseem
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Chemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Biochemistry

description: The formation of new C-C bond through highly regioselective ring opening of chalcone epoxides to nitrogen containing heterocycles has been effectively worked out in impressive yields with heterocyclic nucleophiles such as pyrrole, indole and 2-methyl indole in presence of β-cyclodextrin using water as solvent at room temperature within 25–50 min. Water, an environmentally friendly reaction medium, has been utilized first time for the reaction of these heterocyclic nucleophiles with chalcone epoxides as their β-cyclodextrin complexes to afford 1,3-diaryl-2-hydroxy-3-(1H-3-indolyl/2-pyrrolyl)propan-1-ones (3a-u). The catalyst can be easily recovered and recycled for several times without loss of activity.
INFORME. El viaje de los visitantes. Museos Frida Kahlo y Anahuacalli. 2020 vs
Creators: name: Recuero-Virto, Nuria
Publisher: name: Zenodo
Year: 2021

description: This report is associated with the following publication:

Blasco López, M. F., Recuero Virto, N., & Mondejar, J. A. (2021). Willingness to Pay More: The Quest for Superstar Museums. Academica Turistica - Tourism and Innovation Journal, 14(1). Retrieved from https://academica.turistica.si/index.php/AT-TIJ/article/view/247 

For more information, please visit:https://academica.turistica.si/index.php/AT-TIJ/article/view/247
СОПОСТАВИТЕЛЬНЫЙ АНАЛИЗ ПАРЕМИЙ, ВЕРБАЛИЗУЮЩИХ КОНЦЕПТ «РОДИНА» В РУССКОМ, АНГЛИЙСКОМ И АЗЕРБАЙДЖАНСКОМ ЯЗЫКАХ
Creators: name: Сообщество рецензентов Международного научно-исследовательского журнала
Publisher: name: ИП Соколова М.В.
Year: 2022
Subjects: Пословицы
паремиология
концепт «родина»
сопоставительный анализ
азербайджанский язык
русский язык
английский язык.

description: Russian Linguistic Bulletin 1(29) 4.2022, №1(29) (2022)
Impact of the Galactic magnetic field modelling on studies of the UHECRs arrival direction
Creators: name: Deval, Luca
name: Engel, Ralph
name: Fitoussi, Thomas
name: Roulet, Esteban
name: Unger, Michael
Publisher: name: Scuola Internazionale Superiore di Studi Avanzati (SISSA)
Year: 2025

description: Ultra-high energy cosmic rays (UHECRs) are charged particles of extreme energy that experience
deflections in Galactic and extragalactic magnetic fields as they propagate to Earth. These
deflections limit the ability to trace their arrival directions back to their sources.
In this work, we investigate the impact of Galactic magnetic deflections on cross-correlation
analyses with source catalogs by modeling different configurations of the turbulent and coherent
fields. We show that even when magnetic deflections are applied to simulated data, the best-fit
parameters found by the Pierre Auger Collaboration for the correlation with starburst galaxies can
be recovered with high probability. However, a search for local overdensities in the simulations
predicts secondary structures that are absent in the data. By comparing data and simulations, we
demonstrate how these analyses can constrain the strength of the extragalactic magnetic field.
Cat scratch disease
Creators: name: Prakash Joshi1, Anamika Thakur2, Gugloth Shravni3, Ruchi Manju4
Publisher: name: The Science world a Monthly e magazine
Year: 2024

description: Cat scratch fever, also known as cat scratch disease (CSD), is a bacterial infection caused by Bartonella henselae commonly found in cats. It can be transmitted to humans through scratches, bites, or contact with cat saliva, leading to symptoms like fever, fatigue, and swollen lymph nodes. While most cases are mild and resolve on their own, severe complications can occur, especially in those with weakened immune systems. Understanding the disease's etiology, transmission, symptoms, diagnosis, and prevention is crucial for prompt recognition and management. Prevention strategies include vector control, maintaining personal hygiene, and avoiding contact with cats, while treatment typically involves antibiotics and supportive therapy.
Leicester Water District Analysis (Spring 2016)
Creators: name: Chisholm, Shanel
name: Commisso, James
Publisher: name: QUBES Educational Resources
Year: 2025

description: Delivering high quality drinking water to the residents of a town or city necessitates a robust water management system to ensure the health and safety of its residents. Our report investigates the challenges faced by the water supply districts in the Town of Leicester, Massachusetts. By working together with the Massachusetts Department of Environmental Protection and the Town of Leicester, our goal was to analyze the feasibility of incorporating a collaborative water management system in the Town of Leicester to help alleviate issues of water quality and quantity. In our report, we provide recommendations for the Town of Leicester, its water districts and the Moose Hill Commission on how to collaborate to help Leicester with its current and future water needs
Livelihood diversification and nutrition in the Indian rural-urban interface
Creators: name: Purushotham, Anjali
name: Steinhübel, Linda
Publisher: name: Unknown
Year: 2024
Subjects: subject: Agricultural and Food Policy
subject: Food Consumption/Nutrition/Food Safety
subject: livelihood strategies
subject: dietary transition
subject: fixed-effects regression
subject: rural-urban interface
subject: India

description: With growing cities and improving infrastructure all over the world, smallholder farms not only gain better access to agricultural markets but also off-farm labor markets. As a result, the opportunity cost of farm labor increases, and households’ livelihood portfolios often become more complex, i.e., a share of the household labor is allocated towards off-farm activities. While such diversification is often beneficial for household incomes, the consequences for household nutrition are less clear. Especially, empirical evidence considering the interaction of different employment choices and pathways through which livelihood diversification affects nutrition is still scarce. To address this gap, we first develop a conceptual framework that considers subsistence agricultural production, commercialized agricultural operations, off-farm employment, and the role of market access in explaining household nutrition. Then, we use panel data from the rural-urban interface (RUI) of Bangalore in South India and apply a fixed-effects regression framework to analyze how employment choices affect household consumption of calories, protein, fat, saturated fat, carbohydrates, total sugar, and sodium. We also explore whether the observed effect patterns are driven by income or lifestyle changes associated with livelihood diversification. Our analysis shows that households in the RUI of Bangalore on average consume excess quantities of nutrients considered, indicating the onset of dietary transition that accompanies urbanization. Commercialized agriculture and/or off-farm employment lead to a reduction in the excess consumption of nutrients. This effect is however linked to lifestyle changes, while potential income gains further increase excess consumption. Our analysis also shows that the observed reductions in nutrient consumption through lifestyle changes vary depending on a household’s location in the RUI, with households located close to Bangalore displaying stronger improvements. All in all, livelihood diversification is associated with an improvement in the household nutrient consumption status mediated by lifestyle rather than income factors associated with improved market access.
Distinction and relatedness – Taxonomic and genetic studies reveal a new species group of goatfishes (Upeneus; Mullidae)
Creators: name: Uiblein, Franz
name: Gouws, Gavin
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Marine Biology
subject: Developmental Biology
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Genetics

description: Phenotypic and genetic differentiation among goatfish species of the genus Upeneus which had been formerly included in the so-called ‘vittatus group’ were examined using a comprehensive alpha-taxonomic and barcoding approach. Four of the five species of this group, U. indicus, U. suahelicus, U. supravittatus and U. vittatus, occur in the Western Indian Ocean (WIO), while U. parvus occurs in the Western Atlantic. An updated diagnosis of the WIO species, followed by detailed inter- and intraspecific comparison, is provided based on a large set of morphological and colour characters obtained from 134 specimens. The phenotypic comparisons among all five species and the evidence obtained from barcoding analyses of four species support the separation of U. parvus and U. vittatus from the other three more similar and closely related species which form the here newly established suahelicus group. An identification key for this species group is provided that should also minimize possible confusion with U. vittatus and species of the U. stenopsis group, two of which also occur in the WIO. New records for Madagascar and Saudi Arabia (U. suahelicus), Iran and Pakistan (U. supravittatus) and Sudan (U. vittatus) are reported. Application of this integrative approach to other species groups and species of Upeneus and the need to uncover intra- and interspecific distribution patterns and diversity more fully within the suahelicus group are outlined.
title: 03_1001
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Soil loss assessment in the Turbolo catchment (Calabria, Italy)
Creators: name: Conforti, Massimo
name: Buttafuoco, Gabriele
name: Rago, Valeria
name: Aucelli, Pietro P.C.
name: Robustelli, Gaetano
name: Scarciglia, Fabio
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences

description: Soil loss caused by accelerated erosion is a growing problem in the Mediterranean belt in general, and in many parts of the Calabrian region (Southern Italy), in particular. It is due to the combination of peculiar geomorphological, pedological and climatic features, very often exacerbated by unsuitable land management. The aim of this study is to analyze and map soil loss by water-induced soil erosion at the catchment scale. Soil loss was quantified using the revised universal soil loss equation (RUSLE) model implemented in a geographical information system. The RUSLE is an empirical model which estimates the average annual soil loss that would generally result from splash, sheet and rill erosion. The analysis shows that total soil loss estimated in the study area is 16,470.88 t yr−1 with an average annual soil loss of 5.65 t ha−1 yr−1. Spatial variation and rates of soil erosion are mainly linked to land use, and the rate of soil erosion varies from less than 1 t ha−1 yr−1 in wooded areas to more than 40 t ha−1 yr−1 in barren land. In addition, the comparison between soil loss and slope maps shows that ∼47% of the estimated soil loss involves slopes with a gradient >20°. The map shows seven classes of soil loss, with 8% in the upper three classes and 51% in the lowest class.