cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Efficacy of a Physical Activity Counselling Program with Use of Wearable Tracker in People with Inflammatory Arthritis : A Randomized Controlled Trial
Creators: name: Li, Linda C.
name: Feehan, Lynne M.
name: Xie, Hui
name: Lu, Na
name: Shaw, Chris
name: Gromala, Diane
name: Aviña-Zubieta, J. Antonio
name: Koehn, Cheryl
name: Hoens, Alison
name: English, Kelly
name: Tam, Johnathan
name: Therrien, Stephanie
name: Townsend, Anne F.
name: Noonan, Greg
name: Backman, Catherine
Publisher: name: Arthritis Care & Research
Year: 2021

description: Objectives. To assess the efficacy of a multi-faceted counselling intervention at improving physical activity participation and patient outcomes. Methods. We recruited people with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE). In Weeks 1-8, the Immediate Group received education and counselling by a physiotherapist (PT), used a Fitbit and a web-application to obtain feedback about their physical activity, and received 4 follow-up calls from the PT. The Delay Group received the same intervention in Weeks 10-17. Participants were assessed at baseline, Week 9, 18 and 27. Primary outcome was time spent in moderate/vigorous physical activity (MVPA; in bouts of >10 mins) measured with a SenseWear. Secondary outcomes included step count, time in sedentary behaviour, pain, fatigue, mood, self management capacity, and habitual behaviours. Results. 118 participants enrolled. The adjusted mean difference in MVPA was 9.4 mins/day (95% CI: -0.5, 19.3, P=0.06). A significant effect was found in pain (-2.45; 95% CI: -4.78, -0.13, P=0.04), and perceived walking habit (0.54; 95% CI: 0.08, 0.99, P=0.02). The remaining secondary outcomes improved, but were not statistically significant. Post-hoc analysis revealed a significant effect in MVPA (14.3 mins/day; 95% CI: 2.3, 26.3) and pain (-4.05; 95% CI: -6.73, -1.36) in participants with RA, but not those with SLE. Conclusion. Counselling by a PT has potential to improve physical activity in people with inflammatory arthritis, but further study is needed to understand the intervention effect on different diseases. We found a significant improvement in pain, suggesting the intervention might have a positive effect on symptom management.
The Cederni Altar-Piece by Neri di Bicci in Parma
Creators: name: Kent, Francis W.
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2019

description: -
description: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 33, Nr. 2./3. (1989): Mitteilungen des Kunsthistorischen Institutes in Florenz
Automated Generation of Geometric Digital Twin of Roof for Building Retrofitting
Creators: name: Wang, Mudan
name: Wen, Ya
name: Pan, Yuandong
name: Wang, Guangming
name: Alavi, Hamidreza
name: Kookalani, Soheila
name: Brilakis, Ioannis
Publisher: name: Apollo - University of Cambridge Repository
Year: 2024

description: Digital representations of buildings play a crucial role in building retrofitting and energy modelling. Acquiring sufficient and accurate building data poses challenges, particularly in obtaining geometric information about a building's roof. Previous studies have been conducted on roof detection using aerial laser scanning point cloud data on an urban city scale. However, extracting roof geometry information from individual buildings using terrestrial laser scanning remains a challenging task due to the natural incompleteness of data for building roofs. This research aims to propose a digital twin-based framework for automatically generating the geometric information of existing building roofs required for retrofitting from terrestrial laser scanning point cloud data. The 3D laser scanning technique is adopted for data capturing. The framework includes: (1) collecting and pre-processing the point cloud data, (2) automated detection of the roof points from the building's point cloud, and (3) extracting roof geometry parameters required for building energy modelling. The final output of the proposed method is an information-rich digital twin of the building's roof. The proposed framework is validated through a case study, presenting an automated pipeline to enrich a geometric digital twin of the roof with details. This research contributes to providing geometric information for energy simulation, building energy modelling, and building retrofitting. The findings can be further validated across various building types and applied to urban building energy modelling.
Impact of Medications Used in the Treatment of Mood Disorders on Monoaminergic Systems
Creators: name: Ghanbari, Ramez
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: Depression
Serotonin
Norepinephrine
Dopamine
Bupropion
Trazodone
Asenapine

description: While selective serotonin (5-HT) reuptake inhibitors (SSRIs) are utilized as the first-line strategy in treating depression, new approaches are still desired. Using in vivo electrophysiological techniques, the effects of co-administration of bupropion with the SSRI escitalopram on the firing rate of dorsal raphe 5-HT and locus coeruleus norepinephrine (NE) neurons were investigated. Escitalopram significantly decreased the firing of 5-HT and NE neurons at day 2. The 5-HT firing rate, unlike that of NE, recovered after the 14-day escitalopram regimen. Bupropion did not increase 5-HT firing but decreased that of NE after 2 days. Following 14-day bupropion, 5-HT firing was markedly enhanced, and NE firing was back to baseline. Co-administration of escitalopram and bupropion doubled 5-HT firing after 2 and 14 days, whereas NE neurons were inhibited after 2, but partially recovered after 14 days. Although sustained bupropion administration did not alter the sensitivity of 5-HT1A receptors in hippocampus, the tonic activation of postsynaptic 5-HT1A receptors was enhanced in 14-day bupropion-treated rats to a greater extent than in the 2-day and control rats. The function of terminal 5-HT1B autoreceptors was not changed. The inhibitory action of α2-adrenergic receptors on 5-HT terminals was, however, diminished. The function of terminal α2-adrenergic autoreceptors was also attenuated in rats given bupropion for 14 days. Administration of the antidepressant trazodone suppressed the 5-HT firing at day 2, which recovered to baseline following 14 days. Prolonged trazodone-administration enhanced the tonic activation of postsynaptic 5-HT1A receptors in hippocampus, and decreased the function of terminal 5-HT1B autoreceptors. Finally, a novel psychotropic agent asenapine showed potent antagonistic activity at 5-HT2A, D2, and α2-adrenoceptors. Asenapine, however, acted as a partial agonist at 5-HT1A receptors in dorsal raphe and hippocampus. Overall, the therapeutic effects of various antidepressants may be, at least in part, due to the enhancement of 5-HT and/or NE neurotransmission.
title: Supplement of Decreasing trends of particle number and black carbon mass concentrations at 16 observational sites in Germany from 2009 to 2018
title: Decreasing trends of particle number and black carbon mass concentrations at 16 observational sites in Germany from 2009 to 2018
titleType: AlternativeTitle
Creators: name: Bath, Olaf
name: Sun, Jia
name: Birmili, Wolfram
name: Gerwig, Holger
name: Hermann, Markus
name: Ries, Ludwig
name: Schwerin, Andreas
name: Sohmer, Ralf
name: Meinhardt, Frank
name: Wirtz, Klaus
Publisher: name: My University
Year: 2020

description: Anthropogenic emissions are a dominant contributor to air pollution. Consequently, mitigation policies have attempted to reduce anthropogenic pollution emissions in Europe since the 1990s. To evaluate the effectiveness of these mitigation policies, the German Ultrafine Aerosol Network (GUAN) was established in 2008, focusing on black carbon and sub-micrometer aerosol particles, especially ultrafine particles. In this investigation, trends of the size-resolved particle number concentrations (PNC) and the equivalent black carbon (eBC) mass concentration over a 10-year period (2009-2018) were evaluated for 16 observational sites for different environments among GUAN. The trend analysis was done for both, the full-length time series and on subsets of the time series in order to test the reliability of the results. The results show generally decreasing trends of both, the PNCs for all size ranges as well as eBC mass concentrations in all environments, except PNC in 10-30 nm at regional background and mountain sites. The annual slope of the eBC mass concentration varies between -7.7% and -1.8% per year. The slopes of the PNCs varies from -6.3% to 2.7%, -7.0% to -2.0%, and -9.5% to -1.5% per year (only significant trends) for 10-30 nm, 30-200 nm, and 200-800 nm particle diameter, respectively. The regional Mann-Kendall test yielded regional-scale trends of eBC mass concentration, N[30-200] and N[200-800] of -3.8%, -2.0% and -2.4%, respectively, indicating an overall decreasing trend for eBC mass concentration and sub-micrometer PNC (except N[10-30]) all over Germany. The most significant decrease was observed on working days and during daytime in urban areas, which implies a strong evidence of reduced anthropogenic emissions. For the seasonal trends, stronger reductions were observed in winter. Possible reasons for this reduction can be the increased average ambient temperatures and wind speed in winter, which resulted in less domestic heating and stronger dilution. In addition, decreased precipitation in summer also diminishes the decrease of the PNCs and eBC mass concentration. For the period of interest, there were no significant changes in long-range transport patterns. The most likely factors for the observed decreasing trends are declining anthropogenic emissions due to emission mitigation policies of the European Union. © Author(s) 2020
title: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 33 Nr. 2/3 (1989): Mitteilungen des Kunsthistorischen Institutes in Florenz
title: Mitteilungen des Kunsthistorischen Institutes in Florenz
titleType: AlternativeTitle
Creators: name: Mitteilungen Des Kunsthistorischen Institutes In Florenz
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2019

description: Band XXXIII (1989), Heft 2/3
description: July 1547 in Palazzo Farnese...395-401
A Source for Michelangelo's National Gallery Entombment...390-393
Isabella d'Este, Tiziano e il "quadro di Ser Hieronymo"...385-389
Alberti's Theory of Primitive Sculpture...380-384
The Cederni Altar-Piece by Neri di Bicci in Parma...378-379
Das Wappenbild als Geschichtsquelle. Florentiner Kaufleute in der Genuesenfestung Samastri am Schwarzen Meer...369-377
Zuccari, Scaligero e Panofsky...355-368
Fra Bartolommeo's Landscape Drawings...301-342
Field evaluation of two gross pollutant traps for their pollutant removal efficiencies
Creators: name: Kleijn, Ronald
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2015

description: Over the past two decades, Water Sensitive Urban Design (WSUD) has become an important part of the design of new developments and aims to minimise the effects of development on the natural water cycle. This is achieved, in part, by ensuring the stormwater runoff is treated to a sufficient standard to enable the effluent to be reused and/or released into receiving waters. Structural WSUD systems, or Stormwater Quality Improvement Devices (SQIDs), have seen increased use in South East Queensland to manage stormwater runoff. Design decisions for their use have often been based on performance data supplied by the manufacturers. However field evaluation studies have been limited and performance claims by manufacturers are often based solely on laboratory tests under ideal testing conditions. The objective of this project was to evaluate the stormwater pollution removal performance of two SQID field installations; - the Stormceptor gross pollutant trap (GPT) located at a commercial site in Nambour - the Humegard (GPT) located at the University of the Sunshine Coast campus Field evaluations were conducted for both these GPT systems, following the methodology recommended in Stormwater Australia's 'Stormwater Quality Improvement Devices Evaluation Protocol' or SQIDEP. The GPT's pollution removal performances of three main stormwater pollutants were tested, namely: Total Suspended Solids (TSS), Total Nitrogen (TN) and Total Phosphorous (TP).
A bridge over grey waters: collecting and preserving public policy research
Creators: name: Lawrence, Amanda
Publisher: name: Swinburne
Year: 2024

description: This paper looks at the role of Australian Policy Online (APO) as a collection of ‘grey’ public policy research and considers how this fits within the broader context of open access publishing and policy development. The amount of grey literature now being produced presents challenges for APO as well as other collecting agencies and society in general. This paper looks at who is operating in this space in Australia, the issues for collecting and preserving grey literature, and how bibliographic exchange and interoperability help us to manage the flood of new material and reduce the duplicated effort that currently exists. While APO has been a foundational player in this field, it has reached a stage where a new solution is required - a national online collaborative collection of full text digital resources created with a vision for the benefits that the semantic web will bring.
The quantum confined Stark effect and Wannier Stark ladders in InxGa1-xAs quantum wells and superlattices.
Creators: name: Gibb, Kevin.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Physics, Condensed Matter.

description: The effects of an applied bias in the longitudinal or growth direction on four In$\sb{\rm x}$Ga$\sb{\rm 1-x}$As-GaAs strained single quantum wells and three strained layer superlattices have been studied using photocurrent and electroreflectance spectroscopy at liquid helium temperature. Weak applied electric fields on the quantum well samples gives rise to a red quadratic shift to the lowest interband transition between the first confined electron (E1) and heavy-hole (H1) levels, the quantum confined Stark effect (QCSE). The magnitude of the QCSE increases with well width. This field dependence becomes subquadratic at high applied fields due to carrier accumulation on the low energy side of the wells. Superlattices with relatively small periods, i.e. 10 nm, exhibit interwell coupling giving rise to a miniband structure under flatband conditions. The application of an electric field removes the interwell coupling giving rise to a ladder like progression in energy for the interband transition energies, called Wannier Stark ladders. The measured exciton transition energies follow a linear field dependence given by the product of the Stark ladder index, the superlattice period, and the electric field. The low field behaviour is more complex due to the Coulomb interaction between the electrons and heavy-holes. The measured field dependent exciton transition energies for the quantum wells agree well with single particle model calculations, while for the superlattice samples the exciton Stark ladder calculations of Dignam and Sipe have yielded good agreement with the measured data.
The impact of junior sports sponsorship on consumer-based brand equity
Creators: name: Vance, Leonard
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2017
Subjects: consumer-based brand equity
corporate social responsibility
grassroots sponsorship
junior sport
sponsorship-generated goodwill
sponsorship measurement

description: Sponsorship is a fast-growing marketing and communications tactic, often used as a brand building tool. Despite its popularity, the credibility of sponsorship has come under question, due primarily to a measurement deficiency (Meenaghan and O'Sullivan, 2013). Academics and practitioners alike are seeking more holistic ways to track and measure the impact of sponsorship on business outcomes such as brand equity. Research to date has focused on sponsorship's hierarchy of effects to understand what factors it is comprised of and how those factors influence consumer knowledge, perceptions and behaviour. Unlike traditional forms of marketing communications, such as advertising, sponsorship can generate the consumer knowledge effects of image transfer and sponsorship-generated goodwill for a business. These consumer knowledge effects occur through association with popular activities like community events, sports, the arts, causes, individual teams or celebrities (Pappu and Cornwell, 2014). Yet, a number of gaps remain in the literature including if and how the consumer knowledge effects generated by sponsorship have an impact on sponsor brand equity. This research extends knowledge of this area by empirically testing the impact of sponsorship on sponsor brand equity-using Keller's (1993) notion of consumer-based brand equity (CBBE) as a central framework.
Alcoholism treatment digest (Release No. 88, February 15, 1968)
Creators: name: Keller, Mark
Publisher: name: No Publisher Supplied
Year: 1968

description: The Alcoholism Treatment Digest was a subscription-based publication prepared for special clients by the editorial department of the Quarterly Journal of Studies on Alcohol / Journal of Studies on Alcohol from 1950 to 1973 with Mark Keller as editor. It was published in February, April, June, October, and December, summarizing scholarly content on four topics, available to republish with attribution. Some of the reviews were simultaneously published in the "Connecticut Review on Alcoholism" under the identical subtitle "Alcoholism Treatment Digest" every other month. The authors of the reviews were first noted in 1964, in the June issue.Contents, Release No. 881.Jamming the Revolving Door2.Motion Pictures of Intoxication in Treatment of Alcoholics3.Treating Alcohol Ism with Disulfiram Implantation4.Compulsory Treatment of Criminal Alcoholics
Überlegungen zur Rotationsmechanik von Verrocchios Delphinputto
Creators: name: Passavant, Günter
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2019

description: -
description: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 33, Nr. 1 (1989): Mitteilungen des Kunsthistorischen Institutes in Florenz
The Yoke Impresa of Leo X
Creators: name: Rousseau, Claudia
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2019

description: -
description: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 33, Nr. 1 (1989): Mitteilungen des Kunsthistorischen Institutes in Florenz
Dead to the world: the future of hand-held art
Creators: name: Tofts, Darren
Publisher: name: Swinburne
Year: 2024

description: To be dead to the world used to be a benign idiomatic figure for sleep, temporarily removed from consciousness, cradled in the arms of Morpheus. Now it can be identified as a motif for mobile mania, the fixation on the micro-screen as an indispensable accoutrement of daily life. [Introduction]
Prosecutor Selected Youth Diversion: Identifying the Circumstances and Conceptualizing the Cases
Creators: name: Coady, Kyle N. P.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: youth diversion
extra-judicial sanctions
discretion
Crown prosecutor
Luhmann
systems theory
autopoiesis
diversion

description: Crown selected youth diversion has received little academic attention in Canada. As a process that channels offenders out of the formal legal system, diversion purports to achieve contradictory self-serving system and offender-based goals. Using 50 randomly selected prosecution files – half of which the Crown diverted and half of which the Crown prosecuted – a mixed method investigation of diversion assesses cases through quantitative content analysis and grounded theory method. Based on the quantitative analysis, it is argued that there is an emerging patterned nature of Crown selected diversion that is not completely benign. This patterned nature of diversion unearths a distinctive discourse of diversion/non-diversion. Qualitatively, it is argued that the cases are organized around three temporal moments that create an area for distinctions to be made in terms of threat, responsibility, (in)tolerableness and recourse. Seemingly, there is a persistent paradoxical existence of the diversion process that emerges from the case files.
Trends in the epidemiology of young-onset colorectal cancer : a worldwide systematic review
Creators: name: El Din, Khalid S.
name: Loree, Jonathan M.
name: Sayre, E. C.
name: Gill, Sharlene
name: Brown, Carl J.
name: Dau, Hallie
name: De Vera, Mary
Publisher: name: BioMed Central
Year: 2020

description: Background Recent data suggest that the risk of young-onset colorectal cancer (yCRC), in adults less than 50 years of age, is increasing. To confirm findings and identify contemporary trends worldwide, we conducted a systematic review of studies examining population-level trends in yCRC epidemiology. Methods We searched MEDLINE (1946–2018), EMBASE (1974–2018), CINAHL (1982–2018), and Cochrane Database of Systematic Reviews (2005–2018) for studies that used an epidemiologic design, assessed trends in yCRC incidence or prevalence, and published in English. Extracted information included country, age cut-off for yCRC, and reported trends in incidence or prevalence (e.g. annual percent change [APC]). We pooled similarly reported trend estimates using random effects models. Results Our search yielded 8695 articles and after applying our inclusion criteria, we identified 40 studies from 12 countries across five continents. One study assessed yCRC prevalence trends reporting an APCp of + 2.6 and + 1.8 among 20–39 and 40–49 year olds, respectively. 39 studies assessed trends in yCRC incidence but with substantial variability in reporting. Meta-analysis of the most commonly reported trend estimate yielded a pooled overall APCi of + 1.33 (95% CI, 0.97 to 1.68; p < 0.0001) that is largely driven by findings from North America and Australia. Also contributing to these trends is the increasing risk of rectal cancer as among 14 studies assessing cancer site, nine showed an increased risk of rectal cancer in adults less than 50 years with APCi up to + 4.03 (p < 0.001). Conclusions Our systematic review highlights increasing yCRC risk in North America and Australia driven by rising rectal cancers in younger adults over the past two decades.
title: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 33 Nr. 1 (1989): Mitteilungen des Kunsthistorischen Institutes in Florenz
title: Mitteilungen des Kunsthistorischen Institutes in Florenz
titleType: AlternativeTitle
Creators: name: Mitteilungen Des Kunsthistorischen Institutes In Florenz
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2019

description: Band XXXIII (1989), Heft 1
description: Errata corrige...XLI
Abkürzungsschlüssel...XXXV-XL
Verzeichnisse...VI-XXXIV
Inhalt
Titelei
The Yoke Impresa of Leo X...113-126
Überlegungen zur Rotationsmechanik von Verrocchios Delphinputto...105-112
The Lantern of Michelangelo's Medici Chapel...17-36
A High Altarpiece for San Giovanni Fuorcivitas in Pistoia and Hypotheses about Niccolò di Tommaso...2-16
Investigating the Therapeutic Efficacy of a Novel Inhibitor GAP-107B8 on Ovarian Cancer Cells
Creators: name: Yan, Fu J
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: Ovarian
Therapeutic
Xenograft
Ascites

description: Ovarian cancers often develop resistance mechanisms against the standard platinum and taxane chemotherapy, which indicates the need for novel therapeutics to improve patient outcome. In vitro assays were performed to assess the effects and mechanism of action of a novel peptide, GAP-107B8, on ovarian cancer cell viability. Xenograft models were used to determine GAP-107B8’s effects on tumour burden in immune-incompetent mice. GAP-107B8 significantly reduced cell viability in ovarian cancer cell lines, although no synergistic effects with carboplatin were observed. This reduction in cell viability was due in part to apoptosis and may involve mechanisms leading to decreased pAKT, but without any change in pPKC levels. In vivo, GAP-107B8 had no effect on ovarian tumour burden, but significantly reduced ascites volume. The findings suggest that GAP-107B8 can reduce some malignant characteristics of cancer cells in vitro and in vivo and should be evaluated further as a potential therapeutic for ovarian cancer.
Additional file 4 of A polyclonal allelic expression assay for detecting regulatory effects of transcript variants
Creators: name: Brandt, Margot
name: Gokden, Alper
name: Ziosi, Marcello
name: Lappalainen, Tuuli
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 4. Supplementary figure file containing Figure S1-S5.
Design and Development of a Framework to Bridge the Gap Between Real and Virtual
Creators: name: Hossain, SK Alamgir
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: Haptics
Second Life
Tactile Feedback
Virtual World
Interpersonal Communication
Smart Home
3D Virtual Environment

description: Several researchers have successfully developed realistic models of real world objects/ phenomena and then have simulated them in the virtual world. In this thesis, we propose the opposite: instantiating virtual world events in the real world. The interactive 3D virtual environment provides a useful, realistic 3D world that resembles objects/phenomena of a real world, but it has limited capability to communicate with the physical environment. We argue that new and intuitive 3D user interfaces, such as 3D virtual environment interfaces, may provide an alternative form of media for communicating with the real environment. We propose a 3D virtual world-based add-on architecture that achieves a synchronized virtual-real communication. In this framework, we explored the possibilities of integrating haptic and real world object interactions with Linden Lab's multiuser online 3D virtual world, Second Life. We enhanced the open source Second Life viewer client in order to facilitate communications between the real and virtual world. Moreover, we analyzed the suitability of such an approach in terms of user perception, intuition and other common parameters. Our experiments suggest that the proposed approach not only demonstrates a more intuitive mode of communication system, but also is appealing and useful to the user. Some of the potential applications of the proposed approach include remote child-care, communication between distant lovers, stress recovery, and home automation.
Evaluating and Sustaining Efforts to Limit Nearshore Solid Waste Pollution in a Southeast Asian Island Community
Creators: name: Forsdike, Gary
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2017
Subjects: plastic pollution Indonesia
plastic marine pollution Lombok

description: This study focuses on evaluating and sustaining efforts to control solid waste pollution in a representative nearshore environment on the island of Lombok in Indonesia. Solid waste pollution, particularly pollution by plastics, has been reported in most habitats in the marine environment. All the world's oceans have been cited in scientific literature as being contaminated with solid waste (Ivar do Sul and Costa, 2007). Solid waste may enter coastal waters by inland waterways, wastewater outflows and wind or tide transport, and is widespread. Further, the persistence of much solid waste is such that effects of pollution may be long lasting (Barnes and Milner, 2005).Weathering may fragment solid waste material and make its removal even more difficult (Jambeck et al., 2015).
Characterising the Patterns of Mutational Changes in Human and other Mammalian Populations
Creators: name: Kour, Jaspreet
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2023
Subjects: subject: GC-Biased Gene Conversion
subject: genetic drift
subject: deleterious mutation
subject: single nucleotide polymorphisms
subject: effective population size
subject: population bottleneck
subject: founder effect
subject: genetic diversity
subject: recombination
subject: allele frequency
subject: Bioinformatics and computational biology
subject: Genetics
subject: FOS: Biological sciences

description: A number of studies observed that the genetic diversity among the African population is very high compared to other parts of the world. The diversity of the populations decreases with an increase in the distance from Africa along the routes of the human migration 'Out of Africa'. The major reason for the reduction in the diversity of the populations that are further away from Africa is due to the serial bottlenecks experienced during the processes of migration. A recent study showed that the frequency of the types of nucleotide changes significantly varies among different human populations. The populations that are closer to Africa have more homozygous SNVs with AT→GC changes than those with GC→AT changes. The reason for this was attributed to the phenomenon called GC-biased gene conversion (gBGC). However, this difference between the two types of changes was less pronounced in the populations that are distantly located. It was suggested that this could be due to the difference in the effective sizes of the populations, as it is known that the population size of Africans and those located close to Africa are larger than those located further away from Africa. However, how this will influence the number of different types of minor alleles (e.g., G/C or A/T) in different populations is unclear. Furthermore, if gBGC is influenced by effective population size, it is important to examine its effect on the mainland and Island populations, as they are also known to have high and low (reduced) population sizes, respectively. The gBGC was known to be influenced by the recombination rates of the genome. However, how effective population size modulates this pattern in high and low recombining regions is not known. Finally, the influence of population size on gBGC was studied only using human populations. Therefore, it is imperative to investigate the universality of this pattern in various nonhuman mammalian populations. To address these questions, the present study assembled a dataset containing 420 genomes, including 90 humans, 244 cattle, 36 canines, and 50 mice.
A High Altarpiece for San Giovanni Fuorcivitas in Pistoia and Hypotheses about Niccolò di Tommaso
Creators: name: Ladis, Andrew
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2019

description: -
description: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 33, Nr. 1 (1989): Mitteilungen des Kunsthistorischen Institutes in Florenz
Application of Combinatorial Optimization Techniques in Genomic Median Problems
Creators: name: Haghighi, Maryam
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: median problem
combinatorial optimization
breakpoint median problem
application of travelling salesman problem

description: Constructing the genomic median of several given genomes is crucial in developing evolutionary trees, since the genomic median provides an estimate for the ordering of the genes in a common ancestor of the given genomes. This is due to the fact that the content of DNA molecules is often similar, but the difference is mainly in the order in which the genes appear in various genomes. The mutations that affect this ordering are called genome rearrangements, and many structural differences between genomes can be studied using genome rearrangements. In this thesis our main focus is on applying combinatorial optimization techniques to genomic median problems, with particular emphasis on the breakpoint distance as a measure of the difference between two genomes. We will study different variations of the breakpoint median problem from signed to unsigned, unichromosomal to multichromosomal, and linear to circular to mixed. We show how these median problems can be formulated in terms of problems in combinatorial optimization, and take advantage of well-known combinatorial optimization techniques and apply these powerful methods to study various median problems. Some of these median problems are polynomial and many are NP-hard. We find efficient algorithms and approximation methods for median problems based on well-known combinatorial optimization structures. The focus is on algorithmic and combinatorial aspects of genomic medians, and how they can be utilized to obtain optimal median solutions.
Permeable Pavement Clogging Reduction Study by way of Geometric Modification
Creators: name: Cowie, Brendan
Publisher: name: University of the Sunshine Coast, Queensland
Year: 2013
Subjects: permeable pavement

description: Permeable interlocking concrete paving (PICP) systems are currently implemented as a treatment option in regards to stormwater management. In Australia there is still speculation over what the effective life of a system is, but it is widely held to be around 20 years. Sediment usually accumulates on aggregate bedding in-between pavers eventually reaching a point where it can no longer function as intended, requiring the system to undergo replacement works. Finding a way to increase the effective life of a paving system would result in the reduction of costs associated with maintenance and replacement. Results are presented for eight individual pavement alteration designs examining three different variables; width, depth and shape. Alterations to the pavers were made in the form of slots cut into the base of the pavers to act as channels. The aims were to execute a qualitative sediment accumulation analysis on each of the geometrically modified paver designs and to evaluate the flexural strength of each. A yearly representative sediment sample of 33.885g was added to each pavement design system to simulate 10 years of accelerated sediment loading conditions. It was established that slots cut into the base of the pavers allow sediment to accumulate on the aggregate bedding beneath. A direct relationship was found to exist between slot size and sediment accumulation beneath the pavers, a correlation between slot shape and sediment accumulation could not be established.
Giuliano Periccioli Senese, Disegnatore, Pittore, Cartografo, Incisore e Illustratore
Creators: name: Crinò, Anna Maria
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2019

description: -
description: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 31, Nr. 1 (1987): Mitteilungen des Kunsthistorischen Institutes in Florenz
Locally Nilpotent Derivations and Their Quasi-Extensions
Creators: name: Chitayat, Michael
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Locally Nilpotent Derivation
Commutative Algebra

description: In this thesis, we introduce the theory of locally nilpotent derivations and use it to compute certain ring invariants. We prove some results about quasi-extensions of derivations and use them to show that certain rings are non-rigid. Our main result states that if k is a field of characteristic zero, C is an affine k-domain and B = C[T,Y] / < T^nY - f(T) >, where n >= 2 and f(T) \in C[T] is such that delta^2(f(0)) != 0 for all nonzero locally nilpotent derivations delta of C, then ML(B) != k. This shows in particular that the ring B is not a polynomial ring over k.
Toward an adequate level of detail in flood risk assessments
Creators: name: Sieg, Tobias
name: Kienzler, Sarah
name: Vogel, Kristin
name: Rust, Henning
Publisher: name: My University
Year: 2023
Subjects: Risikoanalyse

description: Flood risk assessments require different disciplines to understand and modelthe underlying components hazard, exposure, and vulnerability. Manymethods and data sets have been refined considerably to cover more details ofspatial, temporal, or process information. We compile case studies indicatingthat refined methods and data have a considerable effect on the overall assess-ment of flood risk. But are these improvements worth the effort? The adequatelevel of detail is typically unknown and prioritization of improvements in aspecific component is hampered by the lack of an overarching view on floodrisk. Consequently, creating the dilemma of potentially being too greedy or toowasteful with the resources available for a risk assessment. A "sweet spot" between those two would use methods and data sets that cover all relevantknown processes without using resources inefficiently. We provide three keyquestions as a qualitative guidance toward this "sweet spot".For quantitativedecision support, more overarching case studies in various contexts are neededto reveal the sensitivity of the overall flood risk to individual components. Thiscould also support the anticipation of unforeseen events like the flood event inGermany and Belgium in 2021 and increase the reliability of flood riskassessments. © 2023 The Authors
Human DENND1A.V2 Drives Cyp17a1 Expression and Androgen Production in Mouse Ovaries and Adrenals
Creators: name: Teves, Maria E.
name: Modi, Bhavi P.
name: Kulkarni, Rewa
name: Han, Angela X.
name: Marks, Jamaia S.
name: Subler, Mark A.
name: Windle, Jolene
name: Newall, Jordan M.
name: McAllister, Jan M.
name: Strauss, Jerome F.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2020

description: The DENND1A locus is associated with polycystic ovary syndrome (PCOS), a disorder characterized by androgen excess. Theca cells from ovaries of PCOS women have elevated levels of a DENND1A splice variant (DENND1A.V2). Forced expression of this variant in normal theca cells increases androgen biosynthesis and CYP17A1 expression, whereas knockdown of the transcript in PCOS theca cells reduced androgen production and CYP17A1 mRNA. We attempted to create a murine model of PCOS by expressing hDENND1A.V2 using standard transgenic approaches. There is no DENND1A.V2 protein equivalent in mice, and the murine Dennd1a gene is essential for viability since Dennd1a knockout mice are embryonically lethal, suggesting that Dennd1a is developmentally critical. Three different hDENND1A.V2 transgenic mice lines were created using CMV, Lhcgr, and TetOn promoters. The hDENND1A.V2 mice expressed hDENND1A.V2 transcripts. While hDENND1A.V2 protein was not detectable by Western blot analyses, appropriate hDENND1A.V2 immunohistochemical staining was observed. Corresponding Cyp17a1 mRNA levels were elevated in ovaries and adrenals of CMV transgenic mice, as were plasma steroid production by theca interstitial cells isolated from transgenic ovaries. Even though the impact of robust hDENND1A.V2 expression could not be characterized, our findings are consistent with the notion that elevated hDENND1A.V2 has a role in the hyperandrogenemia of PCOS.
Additional file 1 of Serum neutrophil gelatinase-associated lipocalin at 3 hours after return of spontaneous circulation in patients with cardiac arrest and therapeutic hypothermia: early predictor of acute kidney injury
Creators: name: Choi, Yoon Hee
name: Lee, Dong Hoon
name: Lee, Jae Hee
Publisher: name: figshare
Year: 2020
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: Additional file 1. General and clinical characteristics of study patients according to AKI stages
The Sforza Antiquities: Two Wills and a Collection
Creators: name: Eiche, Sabine
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2019

description: -
description: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 31, Nr. 1 (1987): Mitteilungen des Kunsthistorischen Institutes in Florenz
La poésie de Patrice Desbiens à l'épreuve de la scène : adaptation textuelle et scénique de L'Homme invisible/The Invisible Man
Creators: name: Proulx, Marie-Pierre
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: Théâtre
Adaptation théâtrale
Théâtre franco-ontarien
Patrice Desbiens
Récit poétique adapté au théâtre
The Invisible Man
L'Homme invisible

description: Depuis l’émergence d’une culture franco-ontarienne dans les années 1970, la poésie a été produite aux côtés du théâtre sur les scènes de la province. Si elle demeure une activité périphérique à la production théâtrale pendant plusieurs décennies, à l’aube des années 2000, elle s’allie réellement à la mise en scène dans le cadre de certaines productions phares. De fait, entre 1998 et 2004, trois metteurs en scène provenant des trois pôles traditionnels de production de l’Ontario français choisissent de porter à la scène les textes du poète Patrice Desbiens. Alors que la poésie est une forme littéraire qui se définit principalement par l’indissociabilité entre forme et contenu, ce mémoire propose une analyse des stratégies textuelles et scéniques privilégiées dans la plus récente des trois productions sus mentionnées : L’homme invisible/The Invisible Man, spectacle produit par le Théâtre de la Vieille 17 à Ottawa en 2004. À l’aide d’outils théoriques tirés des champs de l’adaptation et de la dramaturgie contemporaine, les spécificités propres au récit original et les opérations transformatives qui se sont opérées sont relevées. Les modalités organisatrices de la mise en scène sont ensuite étudiées. Les créateurs réalisent une « adaptation-non-adaptation » (Plana, 2004) dans laquelle, tout en conservant le caractère non-dramatique du texte, ils privilégient l’apparition d’un « métadialogue » (Sermon, 2005) qui s’appuie sur le caractère dualiste et bilingue du récit original. La mise en scène s’articule quant à elle dans la mise en tension de deux modes de figuration tributaires du récit poétique adapté : la métaphore et la métonymie, en faisant un détour par le mimétisme.
The Canadian C-Spine Rule and CT-Head Rule Implementation Studies: A Psychological Process Evaluation
Creators: name: Perez, Richard
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: Clinical Decision Rules
Knowledge Translation
Implementation studies
Theory of Planned Behaviour

description: The Canadian C-Spine (CS) and CT-Head (CT) Rules are tools aimed at improving the accuracy and efficiency of radiography use in emergency departments. This study evaluated whether the Theory of Planned Behaviour (TPB) could explain the inconsistent results from implementation studies of these two rules at 12 Canadian hospitals, where the same intervention resulted in a significant reduction in CS radiography but not CT radiography. It was demonstrated that the TPB model’s proposed relationships between constructs and behaviour could explain the ordering of CS but not CT radiography. However, after examining longitudinal changes of the TPB constructs, it was clear that these changes could not explain the changes in CS radiography ordering. Overall, TPB is unlikely to suggest important ways by which to improve radiography use, for CT because its constructs are not related to radiography ordering, and for CS because of high baseline levels of intention to clinically clear.
Prospero Fontana und Mitarbeiter im Palazzo Vitelli a S. Egidio in Città di Castello Dokumente und Zeichnungen
Creators: name: Kliemann, Julian
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2019

description: -
description: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 31, Nr. 1 (1987): Mitteilungen des Kunsthistorischen Institutes in Florenz
title: Mitteilungen des Kunsthistorischen Institutes in Florenz, Bd. 31 Nr. 1 (1987): Mitteilungen des Kunsthistorischen Institutes in Florenz
title: Mitteilungen des Kunsthistorischen Institutes in Florenz
titleType: AlternativeTitle
Creators: name: Mitteilungen Des Kunsthistorischen Institutes In Florenz
Publisher: name: Mitteilungen des Kunsthistorischen Institutes in Florenz
Year: 2019

description: Band XXXI (1987), Heft 1
description: Prospero Fontana und Mitarbeiter im Palazzo Vitelli a S. Egidio in Città di Castello Dokumente und Zeichnungen...177-194
The Sforza Antiquities: Two Wills and a Collection...162-167
Giuliano Periccioli Senese, Disegnatore, Pittore, Cartografo, Incisore e Illustratore...121-156
Corrigenda-Addenda...XLIII
Abkürzungsschlüssel...XXXVIII-XLIII
Verzeichnisse...V-XXXVII
Inhalt
Titelei
Misère de la sociologie : Nicos Poulantzas et le débat anglais sur la question de l’État dans le Marxisme
Creators: name: Legros, Benoit
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: marxisme
marxisme classique
marxisme ouvert
néo-marxisme
Nicos Poulantzas
théorie de l’État
autonomie de l’État
autonomie du politique
instrumentalisme
économisme
subjectivité

description: La présente thèse a pour objet de contribuer à l’évaluation critique de la sociologie poulantzassienne à l’intérieur du champ de la théorie marxiste de l’État. Dans le cadre d’une appréciation critique du débat anglais, nous chercherons à voir comment peut-on traiter de la sociologie poulantzassienne de l’État - en tant que fondement du néo-marxisme - sur la base d’une théorie marxiste de l’État qui intègre à la fois les acquis du marxisme ouvert et du marxisme classique. Plus précisément, le cadre théorique guidant l’évaluation critique s’articule autour des concepts d’instrumentalisme et d’économisme du marxisme classique, ainsi que la critique du fétichisme des relations sociales de production développée par le marxisme ouvert. Cet examen permet de conclure que le structuro-fonctionnalisme poulantzassien, fondé sur la séparation formelle des structures et de la pratique d’une part, et la séparation formelle du politique et de l’économique d’autre part, mène à une théorie de l’autonomie relative de l’État qui, en plus d’appauvrir la compréhension de phénomènes sociaux contemporains, rejette à l’arrière plan la subjectivité politique et, par le fait même, sème la confusion sur le terrain de la lutte de classe concrète.
Supplementary document for A method for studying cell injury using Quantitative Phase Microscopy - 5275259.pdf
Creators: name: Pouladian, Pegah
name: Yamauchi, Toyohiko
name: Wakida, Nicole M.
name: Gomez-Godinez, Veronica
name: Berns, Michael
name: Preece, Daryl
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)

description: Supplemental material
The Covalent Modification of Proteins: New Therapeutics and Probing Function and Mechanism
Creators: name: Dornan, Mark
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Medicinal chemistry
Chemical biology

description: Covalent bond-forming reactions between small molecules and proteins are ubiquitous. These reactions play a central role in the diversification and functionalization of proteins, enabling normal cell growth and life. Scientists routinely employ electrophilic compounds to modify proteins by exploiting the intrinsic nucleophilicity found on amino acid side-chains. These modifications permit a wide variety of experiments and allow for new insights and a deeper understanding of the chemistry and biology of living systems. The three research projects described in this thesis employ electrophilic, protein-modifying agents to meet unique goals. The first study (Chapter 2) details the development of a novel class of compounds that enhance the efficacy of therapeutic oncolytic viruses specifically in cancer cells. A medicinal chemistry-based approach was used to understand, measure and improve physicochemical and pharmacological properties of these small molecules. Inspired by the unique scaffold identified in Chapter 2, the second study of this thesis (Chapter 3) explores the bioactivity of the structurally related armeniaspirole natural products. Chemical synthesis enabled the uncovering of structure-activity relationships and ultimately allowed for the design of an activity-based probe. The final study (Chapter 4) details investigations of the terminal thioesterase involved in the biosynthesis of valinomycin. Small molecules substrates for the enzyme were synthesized and used to reveal details of the enzymatic mechanisms.