cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Development of a Smart Crop Monitoring System
Creators: name: Sarah Afi, Eman
Publisher: name: American University of Bahrain
Year: 2023
Subjects: classificationCode: 3002
subject: Agriculture, land and farm management
classificationCode: 40
subject: Engineering
classificationCode: 4009
subject: Electronics, sensors and digital hardware

description: This project aimed to develop a sustainable, cost-effective, and user-friendly crop monitoring system that tracks crops and their life stages according to user requirements. The main problem addressed was the need to accurately monitor crops and ensure alignment with client specifications. The overall objectives of the project were to create a platform that enables users to easily access crop data, promote sustainability awareness, ensure profitability and feasibility, explore the implementation of IoT and AI in the agriculture industry, and enhance user-friendliness for farmers and clients, regardless of their technological expertise. The Agile methodology was employed for project development, allowing for flexibility and iterative progress. The 'MoniCrop' application was created as both a web and iOS application, utilizing Visual Studio Code and a localhost server for the web version, and XCode for the iOS version. Various tools, including Raspberry Pi devices, a 7-in-1 NPK sensor, an ultrasonic sensor, and an ESP32 Wi-Fi module, were utilized, alongside programming languages such as Swift, Python, HTML, JavaScript, and CSS. The project successfully achieved its objectives, providing a user-friendly platform for accessing crop data, promoting sustainability awareness, ensuring profitability and feasibility, exploring new microprocessors, understanding sensor implementation, and incorporating IoT and AI in the agriculture industry.
Additional file 1 of Machine learning-based improvement of MDS-CBC score brings platelets into the limelight to optimize smear review in the hematology laboratory
Creators: name: Zhu, Jaja
name: Lemaire, Pierre
name: Mathis, Stéphanie
name: Ronez, Emily
name: Clauser, Sylvain
name: Jondeau, Katayoun
name: Fenaux, Pierre
name: Adès, Lionel
name: Bardet, Valérie
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy
subject: Hematology

description: Additional file 1.
Development of a Smart Crop Monitoring System
Creators: name: Sarah Afi, Eman
Publisher: name: American University of Bahrain
Year: 2023
Subjects: classificationCode: 3002
subject: Agriculture, land and farm management
classificationCode: 40
subject: Engineering
classificationCode: 4009
subject: Electronics, sensors and digital hardware

description: This project aimed to develop a sustainable, cost-effective, and user-friendly crop monitoring system that tracks crops and their life stages according to user requirements. The main problem addressed was the need to accurately monitor crops and ensure alignment with client specifications. The overall objectives of the project were to create a platform that enables users to easily access crop data, promote sustainability awareness, ensure profitability and feasibility, explore the implementation of IoT and AI in the agriculture industry, and enhance user-friendliness for farmers and clients, regardless of their technological expertise. The Agile methodology was employed for project development, allowing for flexibility and iterative progress. The 'MoniCrop' application was created as both a web and iOS application, utilizing Visual Studio Code and a localhost server for the web version, and XCode for the iOS version. Various tools, including Raspberry Pi devices, a 7-in-1 NPK sensor, an ultrasonic sensor, and an ESP32 Wi-Fi module, were utilized, alongside programming languages such as Swift, Python, HTML, JavaScript, and CSS. The project successfully achieved its objectives, providing a user-friendly platform for accessing crop data, promoting sustainability awareness, ensuring profitability and feasibility, exploring new microprocessors, understanding sensor implementation, and incorporating IoT and AI in the agriculture industry.
Additional file 1 of The synergetic effect of Imipenem-clarithromycin combination in the Mycobacteroides abscessus complex
Creators: name: Takei, Satomi
name: Ihara, Hiroaki
name: Togo, Shinsaku
name: Nakamura, Ayako
name: Fujimoto, Yuichi
name: Watanabe, Junko
name: Kurokawa, Kana
name: Shibayama, Kohei
name: Sumiyoshi, Issei
name: Ochi, Yusuke
name: Iwai, Moe
name: Okabe, Takahiro
name: Chonan, Masayoshi
name: Misawa, Shigeki
name: Akimichi Ohsaka
name: Takahashi, Kazuhisa
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Additional file 1: Supplementary figure 1. MIC distributions for amikacin, imipenem, and moxifloxacin combined with clarithromycin, categorized into three subspecies of M. abscessus complex on day 3. Green color indicates susceptibility, yellow color indicates intermediate, and red color indicates resistance to M. abscessus. Abbreviations: CLR, clarithromycin; AMK, amikacin; IPM, imipenem; MXF, moxifloxacin; NA, not assessed. Supplementary figure 2. MIC distributions for amikacin, imipenem, and moxifloxacin combined with clarithromycin, categorized into three subspecies of M. abscessus complex on day 14. Green color indicates susceptibility, yellow color indicates intermediate, and red color indicates resistance to M. abscessus. Abbreviations: CLR, clarithromycin; AMK, amikacin; IPM, imipenem; MXF, moxifloxacin. Supplementary Table 1. The changes of median MIC of clarithromycin and imipenem between monotherapy and combination therapy.
(502513) Martha [Armour]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(502515) Archibald Douglas McMillan
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Yang-Mills theory in the maximal Abelian gauge in presence of scalar matter fields
Creators: name: Capri, M. A. L.
name: Fiorentini, D.
name: Sorella, S. P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We address the issue of the all order multiplicative renormalizability of SU(2) Yang-Mills theories quantized in the maximal Abelian gauge in presence of scalar matter fields. The non-linear character of the maximal Abelian gauge requires the introduction of quartic interaction terms in the Faddeev-Popov ghosts, a well known feature of this gauge. We show that, when scalar matter fields are introduced, a second quartic interaction term between scalar fields and Faddeev-Popov ghosts naturally arises. A BRST invariant action accounting for those quartic interaction terms is identified and proven to be multiplicative renormalizable to all orders by means of the algebraic renormalization procedure.
description: 12 pages
Additional File 7: Pairwise differences in beta diversity between sites for each sample type, based on RPCA analysis
Creators: name: Diner, Rachel
Publisher: name: figshare
Year: 2023
Subjects: Marine and estuarine ecology (incl. marine ichthyology)

description: Addiaitonal File 7 from manuscript: Host and Water Microbiota are Differentially Linked to Human Pathogen Accumulation in Oysters
Improved schmidt conversion of aldehydes to nitriles using azidotrimethylsilane in 1,1,1,3,3,3-Hexafluoro-2-Propanol
Creators: name: Aubé, J.
name: Yin, Q.
name: Motiwala, H.F.
Publisher: name: MDPI AG
Year: 2016

description: The Schmidt reaction of aromatic aldehydes using a substoichiometric amount (40 mol %) of triflic acid is described. Low catalyst loading was enabled by a strong hydrogen-bond-donating solvent hexafluoro-2-propanol (HFIP). This improved protocol tolerates a broad scope of aldehydes with diverse functional groups and the corresponding nitriles were obtained in good to high yields without the need for aqueous work up.
Additional file 5 of The impact of hypothetical PErsonalised Risk Information on informed choice and intention to undergo Colorectal Cancer screening colonoscopy in Scotland (PERICCS)—a randomised controlled trial
Creators: name: Digby, Jayne
name: O’Carroll, Ronan E.
name: Chambers, Julie A.
name: Steele, Robert J. C.
Publisher: name: figshare
Year: 2020
Subjects: Biotechnology
Cancer
Science Policy

description: Additional file 5. Colonoscopy Information Booklet; contains information to explain to participants what would happen before and during a colonoscopy and the risks and complications associated with the test.
Additional file 1 of Conclusiveness, linguistic characteristics and readability of Cochrane plain language summaries of intervention reviews: a cross-sectional study
Creators: name: Banić, Aleksandra
name: Fidahić, Mahir
name: Šuto, Jelena
name: Roje, Rea
name: Vuka, Ivana
name: Puljak, Livia
name: Buljan, Ivan
Publisher: name: figshare
Year: 2022
Subjects: subject: Linguistics
subject: FOS: Languages and literature

description: Additional file 1: Table S1. Frequency distribution of the analyzed PLSs across years. Table S2. Correlation coefficients (Spearman rho correlation coefficient, 95% CI) between year when the plain language summary (PLS) was published, number of authors in a review, Word count, language characteristics and readability level of PLSs. Table S3. Logistic regression of prediction of plain language summaries (PLSs) written before the Standards for the reporting of PLSs in new Cochrane Intervention Reviews (PLEACS) were introduced; PLSs published before the year 2014 are labelled as 0 and those published in 2014 or after are labelled as 1.
Temperature dependence of turnover in a Sc(OTf)3-catalyzed intramolecular Schmidt reaction Dedicated to the memory of Harry Wasserman, an inspirational person and a most elegant scholar
Creators: name: Fehl, C.
name: Li, S.-W.,
name: Aubé, J.
name: Hirt, E.E.
Publisher: name: Elsevier Ltd
Year: 2015

description: The intramolecular Schmidt reaction of ketones and tethered azides is an efficient method for the generation of amides and lactams. This reaction is catalyzed by Lewis acids, which tightly bind the strongly basic amide product and result in product inhibition. We report herein conditions to achieve a catalytic Schmidt reaction using substoichiometric amounts of the heat-stable Lewis acid Sc(OTf)3. This species was shown to effectively release products of the Schmidt reaction in a temperature-dependent fashion. Thus, heat was able to promote catalyst turnover. A brief substrate scope was conducted using these conditions.
Additional file 7 of The impact of hypothetical PErsonalised Risk Information on informed choice and intention to undergo Colorectal Cancer screening colonoscopy in Scotland (PERICCS)—a randomised controlled trial
Creators: name: Digby, Jayne
name: O’Carroll, Ronan E.
name: Chambers, Julie A.
name: Steele, Robert J. C.
Publisher: name: figshare
Year: 2020
Subjects: Biotechnology
Cancer
Science Policy

description: Additional file 7. Internal reliability of study measures; contains the results of statistical tests to measure the internal reliability of several of the study measures.
Additional file 1 of Paradoxical downregulation of LPAR3 exerts tumor-promoting activity through autophagy induction in Ras-transformed cells
Creators: name: Hwang, Sung-Hee
name: Kim, Hye-Gyo
name: Lee, Michael
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer

description: Additional file 1: Suppl. Fig. S1. Generation and validation of the knockout of LPAR3 in Bhas 42 cells LPAR3 KO was confirmed by sequencing for genomic editing at the target site.
(502500) Louisa [Faber]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Microwave Coupling to ECR and Alternative Heating Methods
Creators: name: Celona, L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: The Electron Cyclotron Resonance Ion Source (ECRIS) is nowadays the most effective device that can feed particle accelerators in a continuous and reliable way, providing high-current beams of low- and medium-charge-state ions and relatively intense currents for highly charged ions. The ECRIS is an important tool for research with ion beams (in surface, atomic, and nuclear science) while, on the other hand, it implies plasma under extreme conditions and thus constitutes an object of scientific interest in itself. The fundamental aspect of the coupling between the electromagnetic wave and the plasma is hereinafter treated together with some variations to the classical ECR heating mechanism, with particular attention being paid to the frequency tuning effect and two-frequency heating. Considerations of electron and ion dynamics will be presented together with some recent observations connecting the beam shape with the frequency of the electromagnetic wave feeding the cavity. The future challenges of higher-charge states, high-charge breeding efficiency, and high absolute ionization efficiency also call for the exploration of new heating schemes and synergy between experiments and modelling. Some results concerning the investigation of innovative mechanisms of plasma ignition based on upper hybrid resonance will be described.
description: 20 pages, contribution to the CAS-CERN Accelerator School: Ion Sources, Senec, Slovakia, 29 May - 8 June 2012, edited by R. Bailey
(502510) Robert Marsden Massey
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 2 of Paradoxical downregulation of LPAR3 exerts tumor-promoting activity through autophagy induction in Ras-transformed cells
Creators: name: Hwang, Sung-Hee
name: Kim, Hye-Gyo
name: Lee, Michael
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer

description: Additional file 2: Supplementary Table S1. Real-time PCR primers sequence for genes with hypermethylated DMRs.
A Pan-GTPase inhibitor as a molecular probe
Creators: name: Guo, Y.
name: Wandinger-Ness, A.
name: Ursu, O.
name: Basuray, S.
name: Golden, J.E.
name: Gouveia, K.
name: Agola, J.O.
name: Garcia, M.
name: Sklar, L.A.
name: Carter, M.
name: Simpson, D.S.
name: Schroeder, C.E.
name: Waller, A.
name: Hong, L.
name: Aubé, J.
name: Simons, P.
name: Romero, E.
Publisher: name: Public Library of Science
Year: 2015

description: Overactive GTPases have often been linked to human diseases. The available inhibitors are limited and have not progressed far in clinical trials. We report here a first-in-class small molecule pan-GTPase inhibitor discovered from a high throughput screening campaign. The compound CID1067700 inhibits multiple GTPases in biochemical, cellular protein and protein interaction, as well as cellular functional assays. In the biochemical and protein interaction assays, representative GTPases from Rho, Ras, and Rab, the three most generic subfamilies of the GTPases, were probed, while in the functional assays, physiological processes regulated by each of the three subfamilies of the GTPases were examined. The chemical functionalities essential for the activity of the compound were identified through structural derivatization. The compound is validated as a useful molecular probe upon which GTPase-targeting inhibitors with drug potentials might be developed.
Additional file 1 of Social network-based measurement of abortion incidence: promising findings from population-based surveys in Nigeria, Cote d’Ivoire, and Rajasthan, India
Creators: name: Bell, Suzanne O.
name: Shankar, Mridula
name: Omoluabi, Elizabeth
name: Anoop Khanna
name: Andoh, Hyacinthe Kouakou
name: Funmilola OlaOlorun
name: Danish Ahmad
name: Guiella, Georges
name: Ahmed, Saifuddin
name: Moreau, Caroline
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Statistics
subject: Science Policy

description: Additional file 1. Among respondents who reported an abortion, percentage who shared it with each of their confidantes, overall and by background characteristics. Estimates weighted; bold indicates p-value for design-based F test less than 0.05.
Additional file 3 of Paradoxical downregulation of LPAR3 exerts tumor-promoting activity through autophagy induction in Ras-transformed cells
Creators: name: Hwang, Sung-Hee
name: Kim, Hye-Gyo
name: Lee, Michael
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer

description: Additional file 3: Supplementary Table S2. Real-time PCR primers sequence for genes associated with EMT.
Anisotropic universe space-time non-commutativity and scalar particle creation in the presence of a constant electric field
Creators: name: Zaim, Slimane
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the effect of the non-commutativity on the creation of scalar particles from vacuum in the anisotropic universe space-time. We derive the deformed Klein-Gordon equation up to second order in the non-commutativity parameter using the general modified field equation. Then the canonical method based on Bogoliubov transformation is applied to calculate the probability of particle creation in vacuum and the corresponding number density in the $k$ mode. We deduce that the non-commutative space-time introduces a new source of particle creation.
description: 13 pages, No figures
(502514) Martha Armour
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
What does Relational Governance mean for Data Collaboratives?
Creators: name: Bennett, SJ
Publisher: name: Zenodo
Year: 2023
Subjects: ai ethics
data justice
relational ethics

description: Presented at Data Justice conference '23, at Cardiff University. Data Collaborative initiatives have been developed as a mechanism to facilitate sharing of private data with stakeholders who hold relevant data science and domain skills, with the aim to address challenges related to the public good (Susha et al, 2017). Employing this model, the Scotland-based Data for Children Collaborative was formed with the aim of co-ordinating data collaborative projects which utilise data to address ‘challenges’ pertaining to children in a variety of domestic and international contexts. The use of data in international development contexts requires nuanced analysis of the implications of sourcing data and applying data-driven insights (Heeks and Renken, 2018). Similarly, there are additional facets to account for regarding children’s rights and involvement in data-driven systems, with intersecting marginalisations and vulnerabilities heightening the importance of careful consideration of context and social setting (Krakouer et al, 2021). Developing ethical governance mechanisms forms part of the Data Collaborative approach (Verhulst, 2021). However, these mechanisms often echo the initiatives which they govern in framing data as a resource, with all the connotations of objectivity, utility and generalisability which this framing entails (Kitchin, 2014). Furthermore, ethics approaches within these initiatives largely focus upon the anticipated outputs to be generated by Data Collaborative projects, neglecting the role of project collaborators in shaping data and methods. This paper presentation will explore the implications of taking a data justice oriented approach to ethical governance of data collaboratives, where data and data-driven methods are positioned as relational and contextually situated. Drawing from an 18-month empirical investigation of governance and ethics processes while embedded within a Data Collaborative (the Data for Children Collaborative), this presentation will contribute to ongoing dialogue regarding Data Justice and collaborative data-driven work, reflecting on methods for practically incorporating Data Justice-informed approaches into governance, and the challenges and tensions which arise from this.
(502498) Martha Lintony[?]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus
Creators: name: Bohn, L.M.
name: Morgenweck, J.
name: Aubé, J.
name: Prisinzano, T.E.
name: Frankowski, K.J.
Publisher: name: Elsevier Ltd
Year: 2015

description: The kappa opioid receptor (KOR) is involved in mediating pruritus; agonists targeting this receptor have been used to treat chronic intractable itch. Conversely, antagonists induce an itch response at the site of injection. As a G protein-coupled receptor (GPCR), the KOR has potential for signaling via G proteins and βarrestins, however, it is not clear which of these pathways are involved in the KOR modulation of itch. In this study asked whether the actions of KOR in pruritus involve βarrestins by using βarrestin2 knockout (βarr2-KO) mice as well as a recently described biased KOR agonist that biases receptor signaling toward G protein pathways over βarrestin2 recruitment. We find that the KOR antagonists nor-binaltorphimine (NorBNI) and 5′-guanidinonaltrindole (5′GNTI) induce acute pruritus in C57BL/6J mice, with reduced effects in KOR-KO mice. βArr2-KO mice display less of a response to KOR antagonist-induced itch compared to wild types, however no genotype differences are observed from chloroquine phosphate (CP)-induced itch, suggesting that the antagonists may utilize a KOR-βarrestin2 dependent mechanism. The KOR agonist U50,488H was equally effective in both WT and βarr2-KO mice in suppressing CP-induced itch. Furthermore, the G protein biased agonist, Isoquinolinone 2.1 was as effective as U50,488H in suppressing the itch response induced by KOR antagonist NorBNI or CP in C57BL/6J mice. Together these data suggest that the antipruritic effects of KOR agonists may not require βarrestins.
Co-non-solvency: Mean-field polymer theory does not describe polymer collapse transition in a mixture of two competing good solvents
Creators: name: Mukherji, Debashish
name: Marques, Carlos M.
name: Stuehn, Torsten
name: Kremer, Kurt
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Smart polymers are a modern class of polymeric materials that often exhibit unpredictable behavior in mixtures of solvents. One such phenomenon is co-non-solvency. Co-non-solvency occurs when two (perfectly) miscible and competing good solvents, for a given polymer, are mixed together. As a result, the same polymer collapses into a compact globule within intermediate mixing ratios. More interestingly, polymer collapses when the solvent quality remains good and even gets increasingly better by the addition of the better cosolvent. This is a puzzling phenomenon that is driven by strong local concentration fluctuations. Because of the discrete particle based nature of the interactions, Flory-Huggins type mean field arguments become unsuitable. In this work, we extend the analysis of the co-non-solvency effect presented earlier [Nature Communications 5, 4882 (2014)]. We explain why co-non-solvency is a generic phenomenon that can be understood by the thermodynamic treatment of the competitive displacement of (co)solvent components. This competition can result in a polymer collapse upon improvement of the solvent quality. Specific chemical details are not required to understand these complex conformational transitions. Therefore, a broad range of polymers are expected to exhibit similar reentrant coil-globule-coil transitions in competing good solvents.
The development, assessment and treatment of behaviour problems in young children: integrating children’s own perspectives
Creators: name: Barker, Bethany
Publisher: name: Imperial College London
Year: 2021

description: Background Studies of child development typically rely on the insights of adults to understand children’s behaviour. The value of integrating children’s own perspectives into these investigations has been more widely recognised in recent years. However, such opportunities are rarely extended to very young children, particularly in populations exhibiting challenging behaviours. This thesis contributes empirical evidence to this field by obtaining child-reported data in a large sample of three- and four-year-olds. Using a play-based story stem battery, children’s narrative representations and their relation to children’s behaviour, parental discipline, parental sensitivity, and a video-feedback parenting intervention are explored. Setting, Participants, and Main Measures This research was embedded in the Healthy Start, Happy Start study, a pragmatic randomised controlled trial. Participants were 300 children, who were 12-36 months old and exhibited elevated behaviour problems at screening, and their caregivers. Families were assessed at baseline, 5-month follow-up, and 24-month follow-up. In this thesis, key measures were child behaviour assessed at all time-points, parental sensitivity assessed at baseline and 5-month follow-up, and children’s narrative representations assessed at 24-month follow-up. Results Results from three studies are presented. The first, a cross-sectional study, revealed modest but consistent associations between constructs derived from children’s narratives and parent- and teacher-reported behaviour. The second and third studies were longitudinal and experimental in design. Behaviour problems in toddlerhood were associated with disruptive story themes at three- and four-years-old. Early parental sensitivity was associated with narrative coherence and observed behavioural dysregulation at three- and four-years-old. A video-feedback parenting intervention was found to have small to medium, positive effects on children’s behaviour problems, narrative coherence, and expression of prosocial themes. There was no evidence that improvements to parental sensitivity mediated these relationships. Conclusion This thesis contributes to our understanding of the influences of early behaviour and parent-child interactions on children’s development and highlights the feasibility and unique value of integrating young children’s own perspectives into such investigations.
(502511) (Christopher) Newman Hall
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 6 of The impact of hypothetical PErsonalised Risk Information on informed choice and intention to undergo Colorectal Cancer screening colonoscopy in Scotland (PERICCS)—a randomised controlled trial
Creators: name: Digby, Jayne
name: O’Carroll, Ronan E.
name: Chambers, Julie A.
name: Steele, Robert J. C.
Publisher: name: figshare
Year: 2020
Subjects: Biotechnology
Cancer
Science Policy

description: Additional file 6. Questionnaire Booklet; contains some further questions on participants’ thoughts on having a colonoscopy and on the information provided to them.
Deliverable 2.3 Inventory of post-crisis policies against inequality Innovative local policies against urban inequality
Creators: name: Knorr-Siedow, Thomas
name: Katona, Nóra
name: Kerékgyártó, Anna
name: Gerőházi, Éva
Publisher: name: Zenodo
Year: 2022
Subjects: social innovation
post-crisis
urban areas
policy making

description: This report aims to provide an overview of Social Innovations in the post-crisis era at the 16 locations where the UPLIFT project has been carrying out research activities. Whilst the identification and analysis of (youth related) Social Innovations is not at the centre of the UPLIFT project, this work provides an important addition to the Reflexive Policy Agenda, a key objective of the project. The aim is the introduction of a new, sustainable, participatory policy co-creation process, where young people - who are in the focus of the UPLIFT project - are actively contributing to policies that directly influence their life chances. The contribution of this report is a deeper look into the dynamics of existing Social Innovations; it is not meant to provide a complete or representative overview of the innovation processes in the 16 locations - as only one innovative case was selected in each location - but instead focuses on the mechanisms of particular innovations and the way they interact with the particular context in which they take place.
Characterization of kappa opioid receptor mediated, dynorphin-stimulated [35S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting
Creators: name: Aubé, J.
name: Frankowski, K.J.
name: Prisinzano, T.E.
name: Zhou, L.
name: Lovell, K.M.
name: Stahl, E.L.
name: Bohn, L.M.
Publisher: name: Elsevier Ltd
Year: 2015

description: Abstract Differential modulation of kappa opioid receptor (KOR) signaling has been a proposed strategy for developing therapies for drug addiction and depression by either activating or blocking this receptor. Hence, there have been significant efforts to generate ligands with diverse pharmacological properties including partial agonists, antagonists, allosteric modulators as well as ligands that selectively activate some pathways while not engaging others (biased agonists). It is becoming increasingly evident that G protein coupled receptor signaling events are context dependent and that what may occur in cell based assays may not be fully indicative of signaling events that occur in the naturally occurring environment. As new ligands are developed, it is important to assess their signaling capacity in relevant endogenous systems in comparison to the performance of endogenous agonists. Since KOR is considered the cognate receptor for dynorphin peptides we have evaluated the selectivity profiles of dynorphin peptides in wild-type (WT), KOR knockout (KOR-KO), and mu opioid receptor knockout (MOR-KO) mice using [35S]GTPγS binding assay in striatal membrane preparations. We find that while the small molecule KOR agonist U69,593, is very selective for KOR, dynorphin peptides promiscuously stimulate G protein signaling in striatum. Furthermore, our studies demonstrate that norBNI and 5′GNTI are highly nonselective antagonists as they maintain full potency and efficacy against dynorphin signaling in the absence of KOR. Characterization of a new KOR antagonist, which may be more selective than NorBNI and 5′GNTI, is presented using this approach.
Additional file 1 of Commentary on human pluripotent stem cell-based blood–brain barrier models
Creators: name: Lippmann, Ethan S.
name: Azarin, Samira M.
name: Palecek, Sean P.
name: Shusta, Eric V.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Plant Biology

description: Additional file 1. Additional figures and tables.
Additional file 4 of Paradoxical downregulation of LPAR3 exerts tumor-promoting activity through autophagy induction in Ras-transformed cells
Creators: name: Hwang, Sung-Hee
name: Kim, Hye-Gyo
name: Lee, Michael
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer

description: Additional file 4.
Fractional instantons and bions in the principal chiral model on ${\mathbb R}^2\times S^1$ with twisted boundary conditions
Creators: name: Nitta, Muneto
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Bions are multiple fractional instanton configurations with zero instanton charge playing important roles in quantum field theories on a compactified space with a twisted boundary condition. We classify fractional instantons and bions in the $SU(N)$ principal chiral model on ${\mathbb R}^2 \times S^1$ with twisted boundary conditions. We find that fractional instantons are global vortices wrapping around $S^1$ with their $U(1)$ moduli twisted along $S^1$, that carry $1/N$ instanton (baryon) numbers for the ${\mathbb Z}_N$ symmetric twisted boundary condition and irrational instanton numbers for generic boundary condition. We work out neutral and charged bions for the $SU(3)$ case with the ${\mathbb Z}_3$ symmetric twisted boundary condition. We also find for generic boundary conditions that only the simplest neutral bions have zero instanton charges but instanton charges are not canceled out for charged bions. A correspondence between fractional instantons and bions in the $SU(N)$ principal chiral model and those in Yang-Mills theory is given through a non-Abelian Josephson junction.
description: 30 pages, 2 figures. v2: published version. arXiv admin note: text overlap with arXiv:1412.7681
Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1
Creators: name: Anbanandam, A.
name: De Guzman, R.N.
name: Gowthaman, R.
name: Marquez, R.T.
name: Aubé, J.
name: Gao, P.
name: Liu, H.
name: Larsen, S.
name: Karanicolas, J.
name: Ji, M.
name: Rogers, S.
name: Xu, L.
name: Roy, A.
name: Appelman, C.
name: Wu, X.
name: Cohen, R.S.
name: Lan, L.
name: Neufeld, K.L.
name: Yu, J.
name: Smith, A.R.
Publisher: name: Elsevier B.V.
Year: 2015

description: Musashi-1 (MSI1) is an RNA-binding protein that acts as a translation activator or repressor of target mRNAs. The best-characterized MSI1 target is Numb mRNA, whose encoded protein negatively regulates Notch signaling. Additional MSI1 targets include the mRNAs for the tumor suppressor protein APC that regulates Wnt signaling and the cyclin-dependent kinase inhibitor P21WAF-1. We hypothesized that increased expression of NUMB, P21 and APC, through inhibition of MSI1 RNA-binding activity might be an effective way to simultaneously downregulate Wnt and Notch signaling, thus blocking the growth of a broad range of cancer cells. We used a fluorescence polarization assay to screen for small molecules that disrupt the binding of MSI1 to its consensus RNA binding site. One of the top hits was (-)-gossypol (Ki = 476 ± 273 nM), a natural product from cottonseed, known to have potent anti-tumor activity and which has recently completed Phase IIb clinical trials for prostate cancer. Surface plasmon resonance and nuclear magnetic resonance studies demonstrate a direct interaction of (-)-gossypol with the RNA binding pocket of MSI1. We further showed that (-)-gossypol reduces Notch/Wnt signaling in several colon cancer cell lines having high levels of MSI1, with reduced SURVIVIN expression and increased apoptosis/autophagy. Finally, we showed that orally administered (-)-gossypol inhibits colon cancer growth in a mouse xenograft model. Our study identifies (-)-gossypol as a potential small molecule inhibitor of MSI1-RNA interaction, and suggests that inhibition of MSI1's RNA binding activity may be an effective anti-cancer strategy.
(502497) Sarah Cull[?]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(502496) William Welsh
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Dynamical Backaction Cooling with Free Electrons
Creators: name: Niguès, A.
name: Siria, A.
name: Verlot, P.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The ability to cool single ions, atomic ensembles, and more recently macroscopic degrees of freedom down to the quantum groundstate has generated considerable progress and perspectives in Basic and Technological Science. These major advances have been essentially obtained by coupling mechanical motion to a resonant electromagnetic degree of freedom in what is generally known as laser cooling. In this work, we experimentally demonstrate the first self-induced coherent cooling mechanism that is not mediated by the electromagnetic field. Using a focused electron beam, we report a 50-fold reduction of the motional temperature of a nanowire. Our result primarily relies on the sub-nanometer confinement of the electron beam and generalizes to any delayed and topologically confined interaction, with important consequences for near-field microscopy and fundamental nanoscale dissipation mechanisms.
description: 8 pages, 4 figures
Discovery, Synthesis, and Optimization of Diarylisoxazole-3-carboxamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore
Creators: name: Schiavone, M.
name: Neuenswander, B.
name: Šileikyte, J.
name: Bernardi, P.
name: Forte, M.A.
name: Roy, S.
name: Schoenen, F.J.
name: Chung, T.D.Y.
name: Hedrick, M.P.
name: Argenton, F.
name: Aubé, J.
Publisher: name: John Wiley and Sons Ltd
Year: 2015

description: The mitochondrial permeability transition pore (mtPTP) is a Ca2+-requiring mega-channel which, under pathological conditions, leads to the deregulated release of Ca2+ and mitochondrial dysfunction, ultimately resulting in cell death. Although the mtPTP is a potential therapeutic target for many human pathologies, its potential as a drug target is currently unrealized. Herein we describe an optimization effort initiated around hit 1, 5-(3-hydroxyphenyl)-N-(3,4,5-trimethoxyphenyl)isoxazole-3-carboxamide, which was found to possess promising inhibitory activity against mitochondrial swelling (EC50<0.39 μM) and showed no interference on the inner mitochondrial membrane potential (rhodamine 123 uptake EC50>100 μM). This enabled the construction of a series of picomolar mtPTP inhibitors that also potently increase the calcium retention capacity of the mitochondria. Finally, the therapeutic potential and in vivo efficacy of one of the most potent analogues, N-(3-chloro-2-methylphenyl)-5-(4-fluoro-3-hydroxyphenyl)isoxazole-3-carboxamide (60), was validated in a biologically relevant zebrafish model of collagen VI congenital muscular dystrophies. Stop the pore: Prolonged Ca2+-dependent opening of the mitochondrial permeability transition pore (mtPTP) causes cell death. Herein we describe the discovery of novel small-molecule mtPTP inhibitors with picomolar activity in in vitro assays and high in vivo efficacy in a zebrafish model of muscular dystrophies.
Closing the loops of fast-moving consumer goods
Creators: name: Zeeuw Van Der Laan, Anouk
Publisher: name: Imperial College London
Year: 2021

description: The Fast-Moving Consumer Goods (FMCGs) sector aspires to transition to a Circular Economy (CE) but there is a lack of knowledge and support methods. This research has investigated how material resources flow in FMCG systems and developed new design support for the sector. Initially, the research focused on the moment when resources become obsolete which can disrupt flows. Consumers were found to have critical roles to ensure resource revalorisation and the findings of this study can inform the design of future revalorisation services. Further, it explored Product-Service Systems (PSSs) and studied the elements that could help overcome obsolescence and enable closed loops resource flows. A framework presents these elements, mapped against requirements for PSSs that close loops. Subsequently, the research focused on investigating the resource flow-system, which encompasses all the system elements in place to produce a resource flow. A new modelling method is proposed that describes the movements and transformations of resources and helps configure FMCG sector-specific system elements. The model can be used to explain how FMCG systems work. Finally, a tool called the Flow Mapper is presented, which embeds the modelling method as well as the process to apply it and analyse the model. The tool enables industrial users to develop a holistic view and an in-depth understanding of the resource flowsystem informing the development of future systems solutions.