The influence of storage and heat treatment on a magnesium-based implant material: An in vitro and in vivo study
Creators: name: Bracht, Katja
name: Angrisani, Nina
name: Seitz, Jan-Marten
name: Eifler, Rainer
name: Weizbauer, Andreas
name: Reifenrath, Janin
Publisher: name: London : BioMed Central Ltd.
Year: 2015
Subjects: subject: Degradable
subject: Aluminum
subject: In vitro
subject: In vivo
subject: Magnesium
subject: Storage
subject: Biocompatibility
subject: Computerized tomography
subject: Corrosion
subject: Corrosion resistance
subject: Energy storage
subject: Heat resistance
subject: Heat treatment
subject: Magnesium alloys
subject: Scanning electron microscopy
subject: In-vitro corrosions
subject: In-vivo experiments
subject: Initial stabilities
subject: Simulated body fluids
subject: body fluid
subject: Three point bending
subject: Storage (materials)
subject: alloy
subject: lithium
subject: unclassified drug
subject: animal experiment
subject: animal model
subject: biocompatibility
subject: biomechanics
subject: bone mass
subject: controlled study
subject: corrosion
subject: degradation
subject: energy dispersive spectroscopy
subject: evaluation study
subject: ex vivo study
subject: experimental design
subject: grain
subject: heat treatment
subject: implant
subject: in vitro study
subject: in vivo study
subject: micro-computed tomography
subject: nonhuman
subject: precipitation
subject: priority journal
subject: rabbit model
subject: radiography
subject: scanning electron microscopy
subject: spectroscopy
subject: three point bending
subject: Dewey Decimal Classification::600 | Technik
subject: Dewey Decimal Classification::600 | Technik::610 | Medizin, Gesundheit
subject: Dewey Decimal Classification::500 | Naturwissenschaften::570 | Biowissenschaften, Biologie

description: Background: Magnesium alloys are recommended as a potential material for osteosynthesis. It is known that storage-induced property modifications can occur in materials like aluminum. Thus the aim of this study was to analyze the influence of storage durations of up to 48weeks on the biomechanical, structural, and degradation properties of the degradable magnesium alloy LAE442. Methods: Extruded implants (n=104; Ø 2.5mm×25mm) were investigated after storage periods of 0, 12, 24, and 48weeks in three different sub-studies: (I) immediately after the respective storage duration and after an additional (II) 56days of in vitro corrosion in simulated body fluid (SFB), and (III) 48weeks in vivo corrosion in a rabbit model, respectively. In addition, the influence of a T5-heat treatment (206°C for 15h in an argon atmosphere) was tested (n=26; 0week of storage). Evaluation was performed by three-point bending, scanning electron microscopy, radiography, μ-computed tomography, evaluation of the mean grain size, and contrast analysis of precipitations (such as aluminum or lithium). Results: The heat treatment induced a significant reduction in initial stability, and enhanced the corrosion resistance. In vivo experiments showed a good biocompatibility for all implants. During the storage of up to 48weeks, no significant changes occurred in the implant properties. Conclusions: LAE442 implants can be safely used after up to 48weeks of storage.