cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Obstipation und Überaktive Blase – gibt es ein Crossover zweier geriatrischer Syndrome?
Creators: name: Wiedemann, A.
name: Wechselberger, L.
name: Heppner, H.-J.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Zielsetzung: Ziel der vorliegenden Untersuchung war der Versuch der Reproduktion der in der Literatur postulierten Zusammenhänge zwischen den geriatrischen Syndromen „Obstipation“ und „Überaktive Blase“ (ÜAB) an einem größeren Patientengut als in [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
PREVALENCE, TYPES, AND DEGREE OF HEARING LOSS AMONG PATIENTS CONSULTING RWANDA MILITARY HOSPITAL
Creators: name: Lt. Col. Dr. John BUKURU
Publisher: name: Zenodo
Year: 2024

description: Abstract:

Background: Untreated hearing loss or inadequate support for a person's communication requirements can have a substantial negative impact on their quality of life. Despite this, the prevalence, types, and degree of hearing loss in Rwanda are only sparsely documented.

Objectives: The main goal of this study was to assess the prevalence of hearing loss among patients who consulted the RMH ENT department over the period of three years, from 2019 to 2021.

Methods: At the Rwanda Military Hospital, a three-year retrospective study was conducted with a focus on information regarding patients who consulted for hearing loss complaints between 2019 and 2021. Data were gathered using a user-created questionnaire and were then analyzed using SPSS version 21.0. Numerical data were examined using average and standard deviation whereas categorical and nominal variables were evaluated using frequencies and percentages.

Results: In total, 3823 patients consulted the ENT department at RMH. Of these, 703 (18.4%) were confirmed with hearing loss. The average age of patients with hearing loss was 39.6 ± 23.0 years with 44% of those aged 40 years or above. About 58% of patients with hearing loss were male. Sensorineural hearing loss was the major type for 72%, in addition to conductive hearing loss (15%) and mixed hearing loss (13%). In general, 24% of the patients had profound hearing loss, along with 23% who had moderate hearing loss, 20% who had moderately severe hearing loss, 20% who had severe hearing loss, and 13% who had mild hearing loss. Bilateral hearing loss was reported in 56% of the patients. Chronic suppurative otitis media (CSOM), which was noted in 9% of all patients with hearing loss, despite 72% of the risk factors not being addressed, was followed by trauma (6.5%), presbycusis (4.4%), and acute otitis media (1.7%).

Conclusions: At the Rwanda Military Hospital, hearing loss was prevalent in 18.4% of the cases. About 72% of the patients had sensorineural hearing loss as their primary type of hearing loss. There were 24% and 20% of the patients who had profound and severe hearing loss, respectively. In 56% of the patients, bilateral hearing loss was noted. For 9% of the patients, CSOM was the only significant risk factor. These results indicate that hearing loss is a serious public health concern in Rwanda due to its high prevalence and chronic nature.

Keywords: hearing loss, audiometry, CSOM
Memories of the War of Spanish Succession in eighteenth-century Spain (1714-1758)
Creators: name: Jones Corredera, Eduardo
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Enlightenment
Spanish Empire
Europe
Companies
Early Modern Spain
Modern Spain
Iberian Empires

description: This thesis recovers Spain’s engagement with the Utrecht Enlightenment. Early eighteenth-century Spanish history saw speculation as the means to make sense of a changing world. Political writings transformed social speculation into political debate. Fears about usury failed to influence debates about the merits of enemy investments in imperial joint-stock companies. Speculation fomented scrutiny and deliberation. Political speculation about an alternative set of alliances led Ferdinand VI to venture to secure peace in Europe. The anger that characterised Philip V’s government gave way to bargaining and the currency of war was, for a short period, devalued. Some of the returns on these Spanish investments – such as Andrés Marcos Burriel y López’s quiet study of the intellectual origins of Spanish sovereignty – emerged later in the eighteenth century, and their origins went unacknowledged. Keen observers, such as the Marquis of Pombal, benefited from the Spanish investment in geopolitical speculation, and responded by designing their own system of European alliances. This, then, is a study of how, upon watching a global system of commercial relations and extractive practices slowly dissolve around them, Spanish thinkers imagined visions of progress that devised alternative models of social, political, and transnational cooperation; sources of hope in the possibility that the investment in a shared future would reaffirm trust in politics in a globalised world.
An innovative artificial bee colony algorithm and its application to a practical intercell scheduling problem
Creators: name: Dongni Li
name: Rongtao Guo
name: Rongxin Zhan
name: Yin, Yong
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: In this article, an innovative artificial bee colony (IABC) algorithm is proposed, which incorporates two mechanisms. On the one hand, to provide the evolutionary process with a higher starting level, genetic programming (GP) is used to generate heuristic rules by exploiting the elements that constitute the problem. On the other hand, to achieve a better balance between exploration and exploitation, a leading mechanism is proposed to attract individuals towards a promising region. To evaluate the performance of IABC in solving practical and complex problems, it is applied to the intercell scheduling problem with limited transportation capacity. It is observed that the GP-generated rules incorporate the elements of the most competing human-designed rules, and they are more effective than the human-designed ones. Regarding the leading mechanism, the strategies of the ageing leader and multiple challengers make the algorithm less likely to be trapped in local optima.
Additional file 1 of Helicobacter pylori infection attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in C57/BL6 mice
Creators: name: Wang, Shuxian
name: Wang, Xiaokang
name: Liu, Jiaqi
name: Li, Yaqian
name: Sun, Minghui
name: Zhu, Guoqiang
name: Zhu, Xiaofang
Publisher: name: figshare
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Additional file 1. Ethics approval document
FAMIN Functions at the Interface of Purine, Polyamine and Energy Metabolism
Creators: name: Rodrigues, Rodrigo Pereira De Almeida
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Purine Metabolism
Energy Metabolism
Polyamine Metabolism
IBD
Immunometabolism
FAMIN
LACC1
C13orf31
Crohn's Disease
Orphan Protein
pH homeostasis
Ketone Body metabolism
HepG2 cells
BMDMs
Macrophage Biology
primary Hepatocytes
Mutant Mouse Model

description: The Brazilian National Council for Scientific and Technological Development (CNPq)
The psychological impact of surgical complications on patients and surgeons
Creators: name: Pinto, Anna
Publisher: name: Imperial College London
Year: 2013

description: Adverse events constitute a significant challenge for healthcare organisations not only in terms of their prevention but also in terms of their after-effects on the injured patients and the staff involved. This PhD aims to investigate the psychological impact of surgical complications on patients and surgeons on the basis that the operating room is one of the highest risk areas for serious adverse events. Chapter 1 presents background literature on the aftermath of patient safety incidents both from the patients’ and the healthcare professionals’ perspectives and outlines the gaps of knowledge in this area. Chapter 2 sets the scene for surgical complications and presents the limited existing data on patients’ and surgeons’ experiences of surgical adverse events. Chapter 3 provides an overview of relevant theoretical frameworks for the investigation and discussion of the psychological impact of surgical complications on patients and surgeons. A systematic review of the literature on the psychosocial impact of surgical complications on patients follows in Chapter 4. Chapters 5 and 6 present two empirical studies on surgeons’ experiences of surgical complications. Chapter 5 reports an interview study with 27 surgeons which yielded a range of themes relevant to the personal and professional impact of complications on surgeons, the factors that affect their reactions, their coping, their perceptions of support as well as their perceptions of the institutional cultures in the aftermath of serious complications. Chapter 6 presents a cross-sectional survey study, which aims to quantify the psychological effects of serious surgical complications on surgeons and to identify their psychosocial correlates. Chapters 7 and 8 focus on patients’ experiences of surgical complications. A two time-points interview study with 17 surgical patients who experienced complications of various levels of severity is reported in Chapter 7. This study presents findings relevant to the psychosocial effects of surgical complications on patients, the factors that affect their reactions as well as issues of patient-surgeon communication around complications. Informed by the findings of the systematic review, the patient interview study and relevant literature, a longitudinal cohort study on the psychological impact of surgical complications on patients and the psychosocial predictors of this impact is presented in Chapter 8. Chapter 9 presents an online survey study with patient safety managers on the management of the aftermath of serious patient safety incidents in the NHS. This study investigates how the aftermath of patient safety incidents is managed by NHS organisations and describes the support that is typically available to patients and healthcare staff. Chapter 10 ends with an overview of the key findings from each study, their methodological limitations, directions for future research and implications for supporting surgeons and patients in the aftermath of surgical complications.
Additional file 1: of Evaluating interventions for informed consent for surgery (ICONS): Protocol for the development of a core outcome set
Creators: name: Convie, Liam
name: McCain, Scott
name: Campbell, Jeffrey
name: Kirk, Stephen
name: Clarke, Mike
Publisher: name: figshare
Year: 2018
Subjects: Medicine
Biotechnology
Developmental Biology
Science Policy

description: SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documents. (DOC 121Â kb)
title: Stürze als Teil des „geriatrischen Syndroms Inkontinenz“ – eine Risikoanalyse bei 91 stationär urologischen Patienten
Creators: name: Wiedemann, A.
name: Spranger, F.
name: Heppner, H.-J.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Stürze sind bei geriatrischen Patienten häufig – zu ihren Risikofaktoren gehören u. a. die Überaktive Blase, Nykturie, Polypharmazie und Hyponatriämie. Erstmalig sollten bei stationär-urologischen Patienten die Sturzinzidenz, Sturzort und Sturzzeitpunkt[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
Communicating across difference: Co-cultural theory, capital and multicultural families in Korea*
Creators: name: Han, Eun-Jeong
name: Price, Paula Groves
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Utilizing Orbe’s co-cultural theory and Bourdieu’s theories of capital, this study examines the lived experiences and the communicative interactions employed by members of seven multicultural families in South Korea. Findings show the intertwined roles of economic capital, social capital, cultural capital and symbolic capital with co-cultural communication orientations, when interacting with members of the majority group. Particularly, findings reveal differences between Korean husbands and immigrant wives. For Korean husbands, economic and social capital are the most critical influential factors in their choices of communication orientations, while for immigrant wives, cultural and symbolic capital are most significant. Additionally, contrary to previous research, Confucianism and patriarchy played key roles in the marginalization of Korean men in multicultural families and influenced their co-cultural communication orientations.
Developing beliefs and practices regarding vocabulary teaching through a dialogic approach for professional development: A case study of English language teachers in Hong Kong
Creators: name: Chung, Hiu Yui Edsoulla
Publisher: name: Apollo - University of Cambridge Repository
Year: 2018
Subjects: Teacher development
Beliefs
Belief change
Dialogic reflection
Vocabulary
Sociocultural theory
English as a second language
Hong Kong

description: Given the fundamental role beliefs play in guiding what individuals think and do, it is important to understand teachers’ beliefs and their development in order to facilitate professional growth, which in turn has the potential to promote effective teaching and learning. While research efforts have been devoted largely to investigating teachers’ beliefs, it is surprising that, despite its significance, there is little published data concerning vocabulary teaching, not to mention how professional training contributes to teachers’ change in relation to the language area. This thesis, therefore, seeks to investigate teachers’ epistemological and pedagogical beliefs about vocabulary development, understand their relationship with actual practice, as well as exploring how they develop through a dialogic approach which emphasises interaction and self-reflection. The study reported herein is situated in the context of Hong Kong, where problems relating to the teaching and learning of English vocabulary have been repeatedly highlighted in the literature. It mainly involves six frontline teachers of English as a second language in a local secondary school selected using purposeful sampling. Of these six teachers, four participated in a teacher development programme which focused on dialogic reflection on beliefs and practices regarding vocabulary teaching, whereas the remaining ones did not. Adopting a case study research strategy, the research draws on four major sources of data, including lesson observations, semi-structured interviews, teachers’ professional dialogues and reflective writing, to illuminate issues regarding vocabulary teaching and the process of change. The findings of the study reveal the need to promote teacher professional development regarding vocabulary teaching and develop teachers’ awareness of their own and alternative beliefs and practices. They also provide empirical support for the notion that dialogic reflection helps foster teachers’ change, and enable us to arrive at a better understanding of the complicated nature of teachers’ cognitive and behavioural development. These shed new light on sociocultural theory, generate original insights into how dialogic interaction can be used as a mediational tool to facilitate and understand teacher change in beliefs and practice, as well as providing implications for second language education and teacher professional development.
Radiological, clinical and laboratory based studies in the pathogenesis of desmoid tumours in familial adenomatous polyposis
Creators: name: Bhandari, Santosh
Publisher: name: Imperial College London
Year: 2013

description: Around 10% of desmoid tumours (DT) in familial adenomatous polyposis (FAP) patients grow relentlessly, causing major morbidity and mortality. Radiological, clinical or cellular predictors of aggressive DT are yet to be identified. The work described in this dissertation aimed to identify such predictors by radiological studies, and to develop management guidelines and identify possible targets for therapy. Nine FAP patients with DT underwent 64 multi detector computed tomography (64-MDCT), 1.5 Telsa magnetic resonance imaging (1.5T MRI), Diffusion Tensor Imaging (DTI), Dynamic Contrast Enhanced MRI (DCE-MRI) and Fluorine-18 Flurodeoxyglucose Positron Emission Tomography (18F-FDG PET CT). Direct comparision between 1.5T MRI and 64-MDCT found that MRI was at least equivalent to MDCT in the assessment of DT. DTI was feasible and detected an anisotropic diffusion, which was less directional than in muscle. Metabolic (FDG PET) and vascular imaging (DCE-MRI) of DT demonstrated a spectrum of findings and found that DT were generally hypovascular and poorly glucose avid. A review of nine FAP patients with intra-abdominal desmoid (IAD) and air-fluid level (AFL) on cross sectional imaging found that either a direct communication or translocation of microorganism from bowel led to the development of AFL. Some of these patients could be treated successfully with antibiotics and/or a percutaneous drain; however, the majority ultimately required complex surgery. Full sequence APC mutation analysis performed in three primary DT cell lines detected ‘second hit’ somatic mutation in only one, confirming the establishment of a true DT cell line. A study of choline metabolism using choline kinase alpha (CHKA) as a marker for activation, however, failed to demonstrate up regulation of choline metabolism in desmoid tumour cells. Studies of the Wnt signalling pathways confirmed the activation of canonical Wnt signalling in DT. Interestingly Wnt11, a non-canonical Wnt, was also up regulated in DT.
Additional file 1 of Genome-wide analysis of circRNA regulation during spleen development of Chinese indigenous breed Meishan pigs
Creators: name: Wang, Yifu
name: Cheng, Jinhua
name: Xu, Chao
name: Jin, Jian
name: Bao, Wenbin
name: Wu, Shenglong
name: Wu, Zhengchang
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 1
Investigating gene expression regulation at the level of single genes and whole chromosomes
Creators: name: De Castro Genebra De Jesus, Ines
Publisher: name: Imperial College London
Year: 2012

description: Transcription regulation ensures appropriate gene expression allowing cells to undergo cell differentiation. Gene expression is controlled at multiples levels: locally, through the binding of activating (e.g. RNA Polymerases, RNAPII) or repressive (e.g. Polycomb repressive complexes) proteins; at large‐scale levels where chromosomes occupy discrete territories with implications on nuclear functions. Chromosome reorganisation has been implicated in disease and altered gene expression. In this thesis, I explored two aspects of gene expression regulation. In mouse ES cells, I investigated RNAPII occupancy genome‐wide and compared with Lamin B1 occupancy, reflecting association to the repressive nuclear lamina compartment. I used DamID mapping to determine RNAPII occupancy independently of its post‐translational modifications. Presence of RNAPII at promoter regions of Polycomb‐repressed genes was observed using DamID mapping of Polr2F subunit with the same levels as at active genes, although overall levels of enrichment were low. Comparison with extent of Ser5 phosphorylation at the two groups of genes, suggest that RNAPII at PRC‐repressed genes may be less phosphorylated than at active genes. ChIP experiments using newly available pan‐phospho RNAPII antibodies also suggest that phosphorylation levels at PRC‐repressed genes is lower than that found at active genes. In blood cells from Huntington’s disease (HD) patients and normal individuals, I investigated whether gene deregulation, identified across large genomic regions using Chromowave, is related with changes in chromosome structure. I selected four chromosomes (4, 5, 19 and 22) and performed cryoFISH to study their position, shape and volume. I found that chromosomes structure, especially chromosome 22, is altered in HD. I also selected and measured the expression of a novel set of genes located in genomic regions that have concerted changes in gene expression with HD. I showed that STAG2, encoding a cohesin component, is misexpressed in blood from HD, in both Early and Moderate stages, opening new avenues for HD research.
A survey of Canadian interprofessional student-run free clinics
Creators: name: Ng, Enoch
name: Hu, Tina
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Student-run free clinics (SRFCs) have existed in Canada since 1971, providing interprofessional healthcare to underserved populations. SRFCs are seen as vehicles for socially accountable health professional education. Literature on how Canadian SRFC function is lacking. Web-based surveys were sent to student leaders from Canadian SRFCs regarding their 2014 activities. All six fully-functioning SRFCs responded reporting on the following: services provided, professions involved, governing structure, funding sources, clients seen, types of care sought, students and preceptors involved, as well as perceived strengths, weaknesses, opportunities and threats. In 2014, 2,159 clients were provided clinical care at Canadian SRFCs. The most common reasons for visiting included pain and infection. Strengths identified include autonomy, ability to adapt to client needs, serving the underserved, and real-world interprofessional teamwork. Weaknesses reported include high student and preceptor turnover. Threats include securing funding and liability coverage. Since there is little literature on Canadian SRFCs, we compared our results with United States (US) based SRFCs. Canadian SRFCs share core values with US-based SRFCs and report similar strengths and challenges. However, Canadian SRFCs differ in scope and appear to provide care for more acute concerns. Data from studies of US-based SRFCs may not be immediately applicable to Canadian SRFCs. Studies evaluating Canadian SRFCs are needed.
Active Ageing with Music and Technology: Meaningful Participation and the Situated Use of Technology in Community Music
Creators: name: Mao, Mao
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Active Ageing
Older Adults
Participation
Community Music
Technology Use
Social Practice Theory
Situated Action

description: Scholars and commentators have long advocated the benefits of communal artistic activity for the ageing population. The notion of “Active Ageing” also brings a new angle to the understanding of challenges and opportunities of emerging technologies. In this dissertation, I argue that recognising community music practices and technology use as situated action provides opportunities to grasp the subtleties of social participation and technology use for active ageing. Qualitative and quantitative enquiries were used to (i) uncover the experiences of meaningful participation and the situated use of technology in community music; (ii) unpack the psychological basis of meaningful participation that is sustained by technology use. Drawing on social practice theory by Elizabeth Shove and the situated action approach by Lucy Suchman, this dissertation contributes a productive context of technology use to the richly researched area of community music with older people, and illuminates the complexities of community music practices and the ways in which technological devices coordinate the practices and the implications for active ageing. Two empirical chapters address the two research goals, respectively. Chapter 3 uses qualitative methods and identifies music practices mediated by technology, such as music sharing and revisiting, and how these practices evolve through the reconfiguration of connections between technological devices, competence, meanings, and forward-facing identities. Identity development, via routes such as exercising control, role transitions and social spaces, has psychological significance and implications for the broader concept of active ageing. Building on these findings, we further elucidate how self-efficacy (an exemplar of competence) and motivation (an exemplar of meaning) are associated with the use of digital music technologies (an exemplar of technologies for community music participation) in Chapter 4. Two sets of use patterns that emerge from the quantitative survey data, Contributing and Active interacting, further lend support to the qualitative data. The use of digital music technologies was not determined exclusively by age and employment status, but also by music group memberships and music-technology-specific self-efficacy. Getting social connectedness was a key motivation for more frequent use and sharing using digital music technologies. These results also suggest that age is relevant in thinking about why technology is used in the participants’ particular ways. Drawing upon these findings, I wrote about how HCI can leverage the tenets of active ageing and might facilitate older people’s meaningful participation in community activities with digital music technologies.
description: Cambridge Trust and CSC
Choline kinase inhibition as a treatment strategy of cancers with deregulated lipid metabolism
Creators: name: Trousil, Sebastian
Publisher: name: Imperial College London
Year: 2014

description: Aberrant choline metabolism is a characteristic shared by many human cancers. It is predominantly caused by elevated expression of choline kinase alpha, which catalyses the phosphorylation of choline to phosphocholine, an essential precursor of membrane lipids. In this thesis, a novel choline kinase inhibitor has been developed and its therapeutic potential evaluated. Furthermore the probe was used to elaborate choline kinase biology. A lead compound, ICL-CCIC-0019 (IC50 of 0.27 ± 0.06 μM), was identified through a focused library screen. ICL-CCIC-0019 was competitive with choline and non-competitive with ATP. In a selectivity screen of 131 human kinases, ICL-CCIC-0019 inhibited only 5 kinases more than 20% at a concentration of 10 μM (< 35% in all 131 kinases). ICL- CCIC-0019 potently inhibited cell growth in a panel of 60 cancer cell lines (NCI-60 screen) with a median GI50 of 1.12 μM (range: 0.00389–16.2 μM). Importantly, proliferation of normal cells was only minimally affected (MCF-10A, ST-T1b and CCD-18Co; GI50 30–120 μM). In HCT116 cells, ICL-CCIC-0019 potently inhibited the formation of phosphocholine (EC50 0.67 ± 0.28 μM), which consequently decreased the formation of phosphatidylcholine. The compound arrested cells in the G1 phase of the cell cycle, and induced endoplasmic reticulum stress and apoptosis. A single injection of ICL-CCIC-0019 at 10 mg/kg decreased tumour uptake of the choline kinase specific PET tracer [18F]fluoromethyl-[1,2-2H4]-choline at 24 hours (AUC0–60 –23%). Treatment of HCT116 colon cancer cell xenograft bearing mice with 5 mg/kg ICL-CCIC-0019 i.p. resulted in strong tumour growth inhibition. Human breast cancer cell lines oncogenically transformed by HER2 exhibit increased levels of phosphocholine and are therefore more likely respond to CHKA inhibition. To identify such patients more readily, a novel, non-invasive, PET-imaging-based HER2- targeting diagnostic tool, [18F]GE-226, was developed. [18F]GE-226 (KD = 76 pM) uptake was 11 to 67-fold higher in 10 HER2 positive versus negative cell lines in vitro. Tumour uptake correlated with HER2 expression in 5 different tumour models (r2 = 0.78), and a fluorophore-labelled tracer analogue co-localised with HER2 expression. Tracer uptake was not influenced by short-term or continuous treatment with trastuzumab, but reflected HER2 degradation by short-term HSP90 inhibition. Taken together, these data further validate CHKA as a drug target and warrant the further development of ICL-CCIC-0019, potentially in the setting of HER2 positive cancers.
Analiza widoczności publikacji naukowych polskich humanistów w Internecie
Creators: name: Hołowiecki, Marek
Publisher: name: figshare
Year: 2017
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences

description: Celem raportu jest zbadanie czy przedstawiciele dziedzin naukowych z obszaru nauk humanistycznych i obszaru nauk społecznych (1) posiadają profile w naukowych serwisach internetowych, (2) posiadają stronę internetową mającą charakter wizytówki ich działalności naukowej, (3) posiadają hasło w Wikipedii, (4) wykorzystują możliwości zamieszczania informacji o swoich publikacjach w Internecie. Raport dotyczy widoczności pracowników nauki, którą definiuję jako dostępność w Internecie wskazanych informacji o pracowniku nauki lub jego publikacyjnym dorobku. Celem szczegółowym jest sprawdzenie, jak kształtuje się widoczność pracowników nauki (1) w serwisach społecznościowych umożliwiających założenie profilu uczonemu, (2) na stronach internetowych, na których zawartość uczony ma ograniczony wpływ lub nie ma wpływu.
Raport zawiera dane o widoczności w Internecie 1 355 pracowników naukowych z polskich instytucji naukowych posiadających stopnie naukowe doktora lub doktora habilitowanego w dyscyplinach naukowych z obszaru nauk społecznych lub obszaru nauk humanistycznych.
Dane pobrano 27 lutego 2015 r. z bazy Ogólnopolski wykaz osób, którym nadano stopień doktora lub doktora habilitowanego, stanowiącej część systemu POL-on. Pobrany zbiór zawierał 43 470 rekordów z danymi osób, którzy uzyskały stopień naukowy doktora lub doktora habilitowanego z nauk humanistycznych albo nauk społecznych, zatrudnionych w polskich instytucjach szkolnictwa wyższego lub instytutach naukowych. Stopień doktora posiadało 30 706 osób, a stopień doktora habilitowanego posiadało 12 764 osób.
Raport powstał jako część prac w projekcie Współczesna polska humanistyka wobec wyzwań naukometrii realizowanego w ramach Narodowego Programu Rozwoju Humanistyki0057/NPHR3/H11/82/2014
title: 02_1285
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Effect of the public release of performance information on patient numbers in the English NHS
Creators: name: Laverty, Anthony
Publisher: name: Imperial College London
Year: 2014

description: Abstract Introduction This thesis examines the impact of two special cases of release of quality information on patient utilisation: three NHS trusts heavily publicised as being poor providers of care (the scandal trusts) and NHS trusts highlighted as being the best or worst places for maternity care (the maternity trusts). It also draws on analyses of patient surveys of the information used in making healthcare choices, and whether patient reported quality improved in the maternity trusts. Methods (1) Analysis of a survey of 2,181 patients recently referred for an outpatient appointment. Logistic regression examined socio-demographic factors associated with information use, as well as the likelihood of attending the “local” hospital for treatment. (2) Difference-in-difference analysis of patient numbers between the scandal and maternity trusts and comparison groups using data from Hospital Episode Statistics. (3) Analysis of three patient reported quality measures from two surveys of maternity patients. Results High-profile reports into the quality of care in the scandal trusts had an impact on patient utilisation for only one out of the three trusts, which disappeared six months after report publication. In the maternity trusts there was no change in patient utilisation in trusts highlighted as the best or the worst providers of care. On two out of three measures of patient reported quality trusts publicised as the worst providers did not improve at a faster rate than providers with similar scores at baseline. Discussion Neither the scandal nor maternity trusts experienced declines in levels of patient utilisation. This lack of effect from high-profile reports, which were unequivocal on the quality of care, casts doubt on whether other forms of information reporting will have an impact on patient utilisation. The limited findings on patient reported quality suggest that in the absence of changes in patient utilisation, reporting on specific clinical areas is not associated with improvements.
Development of an Injectable Hydrogel Scaffold for Cardiac Tissue Engineering
Creators: name: Chow, Andre
Publisher: name: Imperial College London
Year: 2013

description: Cardiac failure following myocardial infarction is an important global health issue and a leading cause of morbidity and mortality worldwide. Current treatments do not address the underlying problem of massive cardiomyocyte loss. New tissue engineering strategies may be capable of regenerating or repairing cardiac tissue. The aim of this thesis was to design a cardiac tissue engineering strategy including aspects of biomaterials, cells and soluble factors. For the biomaterial arm a polyethylene glycol (PEG) based hydrogel was designed to match the mechanical properties of myocardial tissue whilst remaining degradable and with the capability of supporting live cells. Injection of the hydrogel into the myocardium demonstrated no significant adverse effects using a Langendorff and in vivo model. Induced pluripotent stem cell-derived cardiomyocytes (iPS-CM) were used as the cellular component of the strategy, with Erythropoietin (Epo) demonstrating protective effects in an in vitro model of cellular injury. A model of rat myocardial infarction was used. The left anterior descending artery was ligated in vivo to create an infarction. Combinations of hydrogel, iPS-CM, and Epo were injected into the infarct border zones with follow up for 8-10 weeks. A combination of hydrogel, iPS-CM and Epo demonstrated significantly more muscularisation and thickness of the infarct zone, with improvements noted in ejection fraction over infarct controls. These results support a multidisciplinary approach to cardiac tissue engineering.
Investigating the Mechanism of Cell Competition in mESCs
Creators: name: George, Nancy
Publisher: name: Imperial College London
Year: 2013

description: Cell competition is a type of cell-cell interaction first described in Drosophila by Morato and Ripoll (1976), whereupon the co-existence of two cell populations with different metabolic properties or growth rates results in the growth of the stronger population at the expensive of the weaker one. BMP2 and 4 are the Drosophila homologues of Decapentaplegic which has been shown to have roles in cell competition. Based on data from studies on Drosophila models of cell competition, the lab generated mESCs null for Bmpr1a and investigated their behaviour when co-cultured with wild-type mESCs as a mammalian model of cell competition. This report further investigates changes in proliferation and apoptosis among competing cells and begins to investigate the signalling pathways which drive loser cells to initiate apoptosis. We report that apoptosis is caspase-dependent and possibly mediated by ERK and Wnt signalling as modulating these pathways changes the dynamics of competing cells. The report utilises a transwell growth system to demonstrate that cell competition is mediated by unknown signalling factors, an observation which has also been described in models of competing cells in Drosophila. The report shows that differentiation of mESCs is an important inducing factor for cell competition as naïve mESCs do not compete. Lastly this study shows that cell competition is a general mechanism of maintaining stem cell quality as other mutations which incur a growth or metabolic disadvantage as mESCs with defects in autophagy or are tetraploid are also eliminated by cell competition when co-cultured with wild-type cells.
title: Lässt sich eine lebenslange SPK-Ableitung bei männlichen geriatrischen Patienten mit Blasenentleerungsstörung durch eine simultane 180-Watt-XPS™-Greenlight-Laserung der Prostata vermeiden?
Creators: name: Wiedemann, A.
name: Knoblauch, M.
name: Heppner, H.-J.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Häufig werden hochbetagte, multimorbide, männliche Patienten nach Harnverhalt oder mit chronischer Blasenentleerungsstörung zur alleinigen Anlage eines suprapubischen Katheters (SPK) als Palliativversorgung eingewiesen. Bisher ist unklar, ob bei diesen „geriatrischen“[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
Educational interventions to enhance competencies for interprofessional collaboration among nurse and physician managers: An integrative review
Creators: name: Clausen, Christina
name: Cummins, Kelly
name: Dionne, Kelley
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Collaborative leadership and management structures are critical to transforming care delivery. Both nurse and physician managers are uniquely positioned to co-lead. However, little is known on how to prepare and support individuals for these co-leader arrangements. The re-design of healthcare professional education focuses on interprofessional collaboration, mutual learning, and a competency-based approach. While competencies for interprofessional collaboration have been delineated, competencies for collaborative management practice have yet to be addressed. An integrative review of empirical studies on existing educational interventions was conducted to critically appraise and synthesise the results regarding collaborative competence among nurse and physician leaders. We reviewed how these interventions have been designed, implemented, and evaluated within workplace settings in order to inform our understanding of what components are effective or ineffective for the future development of an educational programme. This review reports on key characteristics of nine empirical studies and emphasises that: a uniprofessional approach to leadership development is predominant within educational programmes and that the assessment of shared learning experiences are not addressed; there are inconsistency in terms used to describe competencies by individual researchers and limitations within the competency frameworks used in the studies reviewed; and there is a lack of suitable instruments available to assess whether competencies have been achieved through the educational programmes. None of the studies discussed the process of how individuals learned specific competencies or whether learning outcome were achieved. Educational programmes were developed based on a perceived lack of leadership preparation and orientation programmes for leaders in formal management positions and used multiple interventions. Only two of the programmes involved organisational or systems level competencies. Interprofessional co-leading requires enhanced capabilities and capacity for managers. There is a need for developing an in-action education intervention that addresses the unique learning needs of co-leader arrangements particularly among nurses and physicians who are new to their role.
title: Gibt es eine systemische Muskelschwäche als Sturzrisikofaktor nach Botulinum-Toxin-Injektion in den Detrusor? Ergebnisse einer prospektiven Untersuchung urologischer Patienten mit einer geriatrischen Untersuchungsmethode
Creators: name: Wiedemann, A.
name: Haider, S.
name: Heppner, H.-J.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Eine Skelettmuskelschwäche nach Botulinumtoxin-Injektion in den Detrusor zur Behandlung der therapierefraktären Überaktiven Blase wird in Studien durch Patienten mit einer Häufigkeit von knapp 10 % angegeben (Bauer RM, Urol Int 86 (2011): 68-72). Dieses würde[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
CCWI2017: Conference Programme
Creators: name: Collins, Richard
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: CCWI2017: 15th International Computing & Control for the Water Industry Conference5th - 7th September 2017 at the Diamond, University of Sheffield

Conference Programme
The crucial roles of mononuclear phagocytic cells during ventilator-induced lung injury
Creators: name: Waite, Alicia Achiaa Charlotte
Publisher: name: Imperial College London
Year: 2011

description: Acute respiratory distress syndrome remains a significant cause of mortality among intensive care patients. Mechanical ventilation is a crucial component of therapy but can exacerbate injury through overstretch of lung units, known as ventilator-induced lung injury (VILI). The mechanisms by which ventilation triggers the characteristic inflammatory cascade and how this pulmonary inflammation progresses to extrapulmonary organs have not been clearly elucidated. In this work I explored the role of mononuclear phagocytes in the initiation (alveolar macrophages) and subsequent progression (monocytes) of VILI, using in vivo mouse models. Initially, the importance of alveolar macrophages in VILI was clarified by pharmacologically depleting these cells, which substantially attenuated injury. The observation that injurious ventilation led to a decrease in macrophage recoverability led us to hypothesise that adhesive interactions between epithelial cells and macrophages may be important in their activation. To address this, I developed a novel flow cytometric methodology to assess intracellular mitogen activated protein (MAP) kinase phosphorylation in discrete pulmonary cell populations. I was able to demonstrate rapid alveolar macrophage activation, but little epithelial activation, during high stretch ventilation. This potentially indicated that alveolar macrophages directly sense stretch through their adhesive contacts with epithelial cells. I attempted to study this using antibodies to block integrin-mediated interactions, although results were inconclusive. In addition to these experiments, I carried out a preliminary study showing, for the first time, that activated leukocytes marginate to extrapulmonary organs during VILI. This supports the possibility that monocytes and neutrophils play a role in the development of extra-pulmonary organ injury, although this remains undefined. This data shows that mononuclear phagocytic cells are likely to play crucial roles in the pathogenesis of VILI. The findings and methodologies developed provide many possibilities for future research that will enhance our understanding of this iatrogenic injury, ultimately in view of potential therapeutic targets.
Deutschschweizer Geschichtslehrpersonen als Akteure der Themenbestimmung in einer globalisierten Lebenswelt. Ein Fallbeispiel aus einer empirischen Studie
Creators: name: Marti, Philipp
name: Studer, Dominic
Publisher: name: Éditions Alphil
Year: 2023
Subjects: subject: Geschichtslehrpersonen
subject: Geschichtsdidaktik
subject: Unterrichtsplanung
subject: Themenbestimmung
subject: Globalisierte Lebenswelt
subject: Lehrplan
subject: 370 - Erziehung, Schul- und Bildungswesen

description: Der Text behandelt Einflussfaktoren auf die Praxis der Themenbestimmung von gymnasialen Geschichtslehrpersonen im Zeichen einer globalisierten Lebenswelt. Es wurden vier halbstrukturierte Interviews geführt und ausgewertet. Im Text wird ein Interview als Fallbeispiel ins Zentrum gerückt. Wichtiges Ergebnis der gesamten Untersuchung ist, dass die Geschichtslehrpersonen ein Bewusstsein haben für die historischen Orientierungsbedürfnisse der Lernenden. Dennoch wird in den Äusserungen eine eher zögerliche Haltung sichtbar gegenüber Unterrichtsansätzen, die von einer globalisierten Lebenswelt der Schüler*innen ausgehen.