cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Different Effects Of Rosiglitazone In Rat Glioma Cells C6 And Primary Rat Astrocytes
Creators: name: Pankevich, Evgeniia
name: Chistyakov, Dmitry
Publisher: name: Zenodo
Year: 2015
Subjects: Rosiglitazone
glial cells
lipopolysaccharide
cyclooxygenase 2
prostaglandin E2

description: Rosiglitazone is currently used in the treatment of type 2 diabetes and is suggested to be a perspective medicine for neurodegenerative diseases as a regulator of inflammation in central nervous system. The present work is focused on rosiglitazone effect on inflammatory response stimulated by lipopolysaccharide (LPS) in rat astroglioma cells line C6 and primary rat astrocytes. We have estimated the effect at the cyclooxygenase 2 (COX-2) mRNA expression level by qPCR and at the level of signal molecules prostaglandin E?2 (PGE2) release by ELISA method. LPS has been shown to induce the expression of COX-2 mRNA and the PGE?2 release in both glioma cells and primary astrocytes correlating with data previously obtained. The effects of rosiglitazone have been proved out to be opposite. In glioma cells rosiglitazone prevents the COX-2 expression induction and decreases the level of PGE2 release. On the contrary, rosiglitazone increases the inflammatory response stimulated by LPS in primary astrocytes showing pro-inflammatory properties rather than anti-inflammatory. Rosiglitazone alone does not affect the COX-2 expression in glioma but increase PGE2 synthesis activity, while this substance induces the inflammatory response in primary astrocytes. Our data suggest the large differences between mechanisms of rosiglitazone action in inflammatory response in glioma and primary cells opening a new look at drug signaling research in cancer cells.
Broad-band Jet Emission in Young and Powerful Radio Sources: the Case of the CSS Quasar 3C 186
Creators: name: Migliori, G.
name: Siemiginowska, A.
name: Celotti, A.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present the X-ray analysis of a deep ~200 ksec Chandra observation of the compact steep spectrum radio-loud quasar 3C 186 (z=1.06) and investigate the contribution of the unresolved radio jet to the total X-ray emission. The spectral analysis is not conclusive on the origin of the bulk of the X-ray emission. In order to examine the jet contribution to the X-ray flux, we model the quasar spectral energy distribution (SED), adopting several scenarios for the jet emission. For the values of the main physical parameters favored by the observables, a dominant role of the jet emission in the X-ray band is ruled out when a single zone (leptonic) scenario is adopted, even including the contribution of the external photon fields as seed photons for inverse Compton emission. We then consider a structured jet, with the blazar component that- although not directly visible in the X-ray band - provides an intense field of seed synchrotron photons Compton-scattered by electrons in a mildly relativistic knot. In this case the whole X-ray emission can be accounted for if we assume a blazar luminosity within the range observed from flat spectrum radio quasars. The X-ray radiative efficiency of such (structured) jet is intimately related to the presence of a complex velocity structure. The jet emission can provide a significant contribution in X-rays if it decelerates within the host galaxy, on kiloparsec scales. We discuss the implications of this model in terms of jet dynamics and interaction with the ambient medium.
description: 17 pages, 5 figures, 4 tables. Accepted for publication in ApJ
Some Special Cases of Khintchine's Conjectures in Statistical Mechanics: Approximate Ergodicity of the Auto-Correlation Functions of an Assembly of Linearly Coupled Oscillators
Creators: name: Johnson, Joseph F.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mathematical Physics (math-ph)
subject: Probability (math.PR)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We give Sir James Jeans's notion of 'normal state' a mathematically precise definition. We prove that normal cells of trajectories exist in the Hamiltonian heat-bath model of an assembly of linearly coupled oscillators that generates the Ornstein--Uhlenbeck process in the limit of an infinite number of degrees of freedom. This, in some special cases, verifies some far-reaching conjectures of Khintchine on the weak ergodicity of a dynamical system with a large number of degrees of freedom. In order to estimate the theoretical auto-correlation function of a time series from the sample auto-correlation function of one of its realisations, it is usually assumed without justification that the time series is ergodic. Khintchine's conjectures about dynamical systems with large numbers of degrees of freedom justifies, even in the absence of ergodicity, approximately the same conclusions. Para emplear el correlograma de los valores muestrales de un proceso estocástico para estimar su función teórica de autocorrelación, por regla general se asume, sin justificación, que el proceso es ergódico. Pero en 1943, Khintchine conjeturó proposiciones de gran importancia en este asunto, que justificarí an una aproximación a las mismas estimaciones aún sin la ergodicidad del sistema. Mostraremos casos particulares de las conjeturas de Khintchine para asambleas de osciladores lineales.
description: see also http://www.mast.queensu.ca/~jjohnson
Impact of school improvement plans on teachers in the Calgary Board of Education
Creators: name: Ditto, A. George
Publisher: name: University of Calgary
Year: 1990
Subjects: subject: LB 2822.84 C3 D58 1990
subject: School improvement programs - Alberta - Calgary
subject: School principals - Alberta - Calgary - Attitudes
subject: Teachers - Alberta - Calgary - Attitudes

description: Bibliography: p. 160-170.
Counter-Orbiting Tidal Debris as the Origin of the MW DoS
Creators: name: Pawlowski, Marcel S.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The Milky Way satellite galaxies show a phase-space distribution that is not expected from the standard scenario of galaxy formation. This is a strong hint at them being of tidal origin, which would naturally explain their spacial distribution in a disc of satellites. It is shown that also their orbital directions can be reproduced with the debris of galaxy collisions. Both co- and counter-orbiting satellites are formed naturally in merger and fly-by interactions.
description: 2 pages, 1 figure, to appear in the proceedings of the conference "Assembling the Puzzle of the Milky Way", Le Grand Bornand (Apr. 17-22, 2011), to be published in EPJ Web of Conferences
Pathway Activation Strength (Pas) Analysis Of Microarray Data Reveal Similarities Of Aging With Age-Related Macular Degeneration And Hutchinson-Gilford Progeria ? Should Aging Be Considered As A Disease?
Creators: name: Makarev, Eugene
name: Zhavoronkov, Alex
name: Aliper, Alex
Publisher: name: Zenodo
Year: 2015
Subjects: Aging
AMD
Hutchinson-Gilford progeria

description: Aging is a complex multifactorial process leading to loss of function and age-related diseases. However, the contribution of aging to age-related diseases is still poorly understood. In this research study we compared differential tissue-specific pathway activation profiles in normal aging with progeria, Age-related Macular Degeneration (AMD). We discovered the age-related diseases share similarity with healthy aging at the signaling pathways level
Land for Informal Recreation in London's Green Belt, 1978
Creators: name: Harrison, C. M.
Publisher: name: UK Data Service
Year: 1982

description: This survey of visitor use of 16 public open spaces was designed to examine: -
 (1) Characteristics of visitors;
 (2) Trip characteristics and site catchment areas;
 (3) Motivations and preferences of visitors.
The Acetogenic-Based Bis-Tetrahydropyran 1,4-Triazole, Jm425 Potentially Targets The Trypanosomatid Mitochondrial Complex V
Creators: name: Tulloch, Lindsay
name: Menzies, Stefanie K.
name: Fraser, Andrew L.
name: Gould, Eoin R.
name: Morris, Joanne C.
name: King, Elizabeth F.
name: Zacharova, Marija K.
name: Smith, Terry K.
name: Florence, Gordon J.
Publisher: name: Zenodo
Year: 2015
Subjects: acetogenin
trypanosoma
bis-tetrahydropyran triazole
ATP synthase

description: The acetogenin family of polyketides produced by annonaceacous plants has broad anti-microbial activity through its potent inhibition of mitochondrial complex I. We recently reported [Florence, Chem. Med. Chem. 9;2548 (2014)] the trypanocidal activity of a series of novel synthetic bis-tetrahydropyran 1,4-triazole (B-THP-T) analogues based on the framework of the acetogenin chamuvarinin. These compounds are active against both bloodstream and procyclic (insect) forms of Trypanosoma brucei, the parasite responsible for African sleeping sickness, also known as Human African Trypanosomiasis (HAT). T. brucei lacks functional complex I, so this study aimed to identify the target of our B-THP-T compounds in this important parasite. We performed pull-down experiments with a cross-linkable B-THP-T compound (ALF072) and identified the alpha- and beta- subunits of the FoF1 ATP synthase (mitochondrial complex V) as potential targets in the procyclic form. Next we undertook a series of biological analyses to validate this pull-down. Using a luciferase-based ATP quantitation assay we show that our lead B-THP-T compound (JM425) inhibits cellular ATP production from proline metabolism in the procyclic form, and specifically ablates oxidative phosphorylation in isolated procyclic form mitochondria, but has little effect on substrate-level ATP production. Imaging with MitoTracker dye revealed that JM425 elevates the procyclic mitochondrial membrane potential, consistent with inhibition of mitochondrial complex V, and support our pull-down of the regulatory (alpha) and catalytic (beta) subunits of the FoF1 ATP synthase. Complex V is essential for both bloodstream and procyclic T. brucei and is an attractive drug target. With the target of our bis-tetrahydropyran 1,4-triazoles identified as mitochondrial complex V a structure-based approach can be used to optimize inhibitor potency and specificity.
Research Report “Economic and social situation of Ukrainian women -forced migrants in Ukraine and Poland”.
Creators: name: Huliaieva, Liudmyla
Publisher: name: figshare
Year: 2023
Subjects: Labour economics
Financial economics
International economics
Urban and regional economics
Welfare economics
Behavioural economics
Women's studies (incl. girls' studies)
Household finance and financial literacy
Education policy
Poverty, inclusivity and wellbeing
Socio-economic development
Sociology of gender
Sociology of migration, ethnicity and multiculturalism

description: Research Report “Economic and social situation of Ukrainian women -forced migrants in Ukraine and Poland”. 2023. 10.6084/m9.figshare.23597091
 The scientific project titled “Economic and Social Situation of Ukrainian Women-Forced Migrants in Ukraine and Poland” was funded by the IWM-PIASt Fellowship Program (IWM-PIASment, 2022).
Children's Difficulties on Starting Infant School, 1975 and 1977
Creators: name: Hughes, M.
name: Pinkerton, G.
Publisher: name: UK Data Service
Year: 1981

description: The purpose of this study was to provide descriptive information on the nature and extent of children's difficulties on starting infant school (1975), and the extent to which these difficulties were affected by factors concerned with the organisation of the school intake, such as the age at which children started, the time of year when they started, and the size of the class which they joined. A subsample of the original entrants was followed up in 1977 to obtain some idea of how long their difficulties persisted. Difficulties were assessed by a 13 item rating scale covering all aspects of the child's behaviour. This scale was completed for each child individually by the child's teacher.
A priori estimates for the complex Hessian equations
Creators: name: Dinew, Slawomir
name: Kolodziej, Slawomir
Publisher: name: arXiv
Year: 2011
Subjects: subject: Complex Variables (math.CV)
subject: FOS: Mathematics

description: We prove some $L^{\infty}$ a priori estimates as well as existence and stability theorems for the weak solutions of the complex Hessian equations in domains of $C^n$ and on compact Kähler manifolds. We also show optimal $L^p$ integrability for m-subharmonic functions with compact singularities, thus partially confirming a conjecture of Blocki. Finally we obtain a local regularity result for $W^{2,p}$ solutions of the real and complex Hessian equations under suitable regularity assumptions on the right hand side. In the real case the method of this proof improves a result of Urbas.
description: 18 pages, preliminary version
Competing models of illness and disease: the study of leishmeniasis in Campeche, Mexico
Creators: name: Downe, Pamela J. A.
Publisher: name: University of Calgary
Year: 1990

description: Bibliography: p. 155-164.
description: Health intervention programs often fail because the biomedical model and folk model of disease are in competition and are incongruous. There is a need for an integrated explanatory model of disease that accounts for both the clinical and cultural perspectives. The purpose of this study is to construct such a model. The parasitic disease, leishmaniasis, in Campeche, Mexico is the subject of this investigation. Five rural villages in the tropical forest of Southern Campeche were studied in order to determine the cultural perceptions of the disease. This research was conducted over a three month period in association with an ongoing investigation of leishmaniasis centered in the University of Yucatan, Merida. The construction of the integrated model requires that a folk model of the disease be developed first. This involves two processes. The introductory study sets forth the broader, cultural beliefs of health and illness in general. The second study develops a specific model of leishmaniasis encompassing the popular, family and expert models. The results of these investigations show that the concepts of strength, equilibrium, personal responsibility, and the etiological agent are prominent to the people's understanding of disease. The symptomatic severity is determined by the degree of incapacitation, pain, and life endangerment. Criteria for treatment success includes the rapidity of cure, painlessness, and ease of access to the treatment. Patient trust is also crucial to treatment choice. Therefore, herbal and self - administered treatments are preferred for all diseases. Leishmaniasis is considered to be severe given the associated economic loss, role strain, pain, and treatment availability. The biomedical model may be drawn from the ongoing medical investigations and the current literature. Biomedically, leishmaniasis is considered to be very mild and non-burdening. The synthesized model is constructed for the health intervention strategy. The disparities between the two competing models may be resolved by expanding the categories of the existing models or by bridging the two models with a new construct. The contrasting perceptions of the burden of illness is the greatest impediment to the intervention campaign. Therefore, the bridging mechanism proposed is a systematic scoring method that provides a standardized, repeatable measure of burden. This measure accounts for both models and may provide an evaluative mechanism for the intervention. The efficacy of the intervention may improve as the burden of leishmaniasis is clarified and refined, outlining the specific targets of the health care program. The process involved in the construction of these models may be utilized in the study of other diseases and the intervention attempts, particularly when the existing models of the disease are incongruous. This study emphasizes the relevance of anthropological inquiry to the health care intervention process.
Face Morphing Attack Detection with Denoising Diffusion Probabilistic Models
Creators: name: Ivanovska, Marija
name: Štruc, Vitomir
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Morphed face images have recently become a growing concern for existing face verification systems, as they are relatively easy to generate and can be used to impersonate someone's identity for various malicious purposes. Efficient Morphing Attack Detection (MAD) that generalizes well across different morphing techniques is, therefore, of paramount importance. Existing MAD techniques predominantly rely on discriminative models that learn from examples of bona fide and morphed images and, as a result, often exhibit sub-optimal generalization performance when confronted with unknown types of morphing attacks. To address this problem, we propose a novel, diffusion-based MAD method in this paper that learns only from the characteristics of bona fide images. Various forms of morphing attacks are then detected by our model as out-of-distribution samples. We perform rigorous experiments over four different datasets (CASIA-WebFace, FRLL-Morphs, FERET-Morphs and FRGC-Morphs) and compare the proposed solution to both discriminatively-trained and once-class MAD models. The experimental results show that our MAD model achieves highly competitive results on all considered datasets.
description: Published at IWBF 2023
Workplace Industrial Relations, 1978
Creators: name: Brown, W.
Publisher: name: UK Data Service
Year: 1981

description: The purpose of this survey was to obtain a representative picture of the institutions and conduct of industrial relations in British manufacturing industry in 1978. Apart from obtaining a `map' of industrial relations institutions, this survey was intended to permit the testing of a number of hypotheses on strike patterns, bargaining practices, and trade union organisation.
Ginzburg-Landau slopes of the anisotropic upper critical magnetic field and band parameters in the superconductor (TMTSF)2ClO4
Creators: name: Lebed, Andrei
Publisher: name: arXiv
Year: 2012
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We theoretically determine the Ginzburg-Landau slopes of the anisotropic upper critical magnetic field in a quasi-one-dimensional superconductor and correct the previous works on this issue. By using the experimentally measured values of the Ginzburg-Landau slopes in the superconductor (TMTSF)$_2$ClO$_4$, we determine band parameters of its electron spectrum. Our main result is that the so-called quantum dimensional crossover has to happen in this material in magnetic fields, $H = 3-8 \ T$, which are much lower than the previously assumed. We discuss how this fact influences metallic and superconducting properties of the (TMTSF)$_2$ClO$_4$.
description: 8 pages, 1 table
Survey of Industrial Tribunals, 1973
Creators: name: Social And Community Planning Research
Publisher: name: UK Data Service
Year: 1983

description: The purpose of this survey was to seek the views of those involved as applicants to industrial tribunals (dismissed employees who apply for a tribunal hearing) and respondents (members of the establishment from which the application was dismissed who were most closely involved with the case) to consider the possible advantages that Legal Aid representation might bring. This survey formed part of a broader inquiry involving the examination of case files retained by the Regional Offices of Industrial Tribunals and Department of Employment Conciliation officers, and a survey of Tribunal Chairmen, side Members, Tribunal staff and Conciliation Members.
Solent Study, 1978
Creators: name: Social And Community Planning Research
Publisher: name: UK Data Service
Year: 1984

description: The aims of this survey were:
 (i) To establish what aspects of general aviation at small airfields cause annoyance and the degree of anoyance caused;
 (ii) to find out whether the NNI formula used at major airports was also applicable to general aviation;
 (iii) to develop indices of night time annoyance and relate these to measures of night noise exposure.
 The general aviation airfield selected for the study was Hamble airport, based on the east side of Southampton Water and used almost solely as a training centre for aircraft pilots.
Simplinext: The Next Generation Of Well-Plate Inserts For Predictive Model Of Biological Barriers
Creators: name: Suter, Silvia Angeloni
Publisher: name: Zenodo
Year: 2015
Subjects: biological barriers
nanotoxicology
early stage
In vitro

description: Advancing in-vitro through innovation and ergonomics. SiMPLI next venture project leverages advances in human tissue models into new opportunities for in-vitro testing. SiMPLI inserts are a new generation of Transwells like inserts uniquely capable of exposing transport properties of larger molecules such as nanoparticles, fine particles and aggregates.
Phase equilibria in gas hydrate forming systems in the presence of electrolytes or methanol, and e
Creators: name: Englezos, Petros
Publisher: name: University of Calgary
Year: 1990
Subjects: subject: QC 318 T47 E64 1990
subject: Thermodynamic equilibrium
subject: Natural gas - Hydrates
subject: Equations of state

description: Bibliography: p. 207-226.
description: offsite
Survey of the Long Term Unemployed, 1979
Creators: name: Manpower Services Commission
Publisher: name: UK Data Service
Year: 1981

description: The aim of this survey was to provide information on:
 (a) the educational, training and employment backgrounds of the long-term unemployed to indicate their potential for work and training;
 (b) the social, physical and psychological factors affecting their ability to take up work or training; and
 (c) their attitudes towards various Manpower Services Commission programmes.
A Native model of community based sobriety
Creators: name: Evans, Heather Anne
Publisher: name: University of Calgary
Year: 1990
Subjects: subject: HV 5283 C32 A448 1990
subject: Indians of North America - Alberta - O'Chiese Reserve - Alcohol use - Case studies
subject: Alcoholism - Treatment - Alberta - O'Chiese Reserve - Case studies

description: Bibliography: p. 277-284.
Pre-Implantation Genetic Screening Using Semiconductor High-Throughput Sequencing
Creators: name: Korostin, Dmitriy
Publisher: name: Zenodo
Year: 2015
Subjects: PGS
NGS

description: Embryo chromosomal abnormalities can cause early pregnancy loss and failure of ART programs. Pre-implantation genetic screening (PGS) allows detecting chromosomal abnormalities before embryo transfer and raises the efficiency of ART. Now for PGS FISH and aCGH technologies are used. Development of high-throughput sequencing methods and prices reduction can allow performing PGS quicker and cheaper.

The aim of this study was to estimate possibility to perform PGS using semiconductor high-throughput sequencing and to compare sequencing and comparative genomic hybridization results.

In this study, eight embryo cell samples were analyzed. According to aCGH results, we had two samples with normal karyotype, 3 samples with aneuploidies and 3 chaotic samples.

Comparative genomic hybridization was performed using SurePrint G3 Human CGH 8x60K Microarray (Agilent, USA). Multiplexed sequencing (4 samples/chip) was performed using Ion PGM Torrent 316v1 chip (Life Technologies Thermo Fisher). Sequencing results were analyzed using in-house developed pipeline.

The results obtained using comparative genomic hybridization and semiconductor sequencing were identical. This study confirmed that Ion Torrent sequencing technology could be used for PGS. Further validation of sample processing and data analysis pipeline is necessary.
Acceleration of particles by rotating black holes: near-horizon geometry and kinematics
Creators: name: Zaslavskii, O. B.
Publisher: name: arXiv
Year: 2011
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Nowadays, the effect of infinite energy in the centre of mass frame due to near-horizon collisions attracts much attention.We show generality of the effect combining two seemingly completely different approaches based on properties of a particle with respect to its local light cone and calculating its velocity in the locally nonrotaing frame directly. In doing so, we do not assume that particles move along geodesics. Usually, a particle reaches a horizon having the velocity equals that of light. However, there is also case of "critical" particles for which this is not so. It is just the pair of usual and critical particles that leads to the effect under discussion. The similar analysis is carried out for massless particles. Then, critical particles are distinguishable due to the finiteness of local frequency. Thus, both approach based on geometrical and kinematic properties of particles moving near the horizon, reveal the universal character of the effect.
description: 8 pages
Second Survey of Aircraft Noise Annoyance around London (Heathrow) Airport, 1967
Creators: name: MIL Research Limited
name: Censuses, Office Of Population
Publisher: name: UK Data Service
Year: 1980

description: The aim of this survey was to measure the change between 1961 and 1967 in levels of noise exposure and in social reactions to aircraft noise; to investigate whether the findings of the 1961 survey remain valid in 1967; to increase knowledge of the ways in which exposure to aircraft noise affects annoyance; to obtain miscellaneous information bearing on the problem of noise control at airports.
 The 1961 survey Aircraft Noise Annoyance Around London (Heathrow) Airport, 1961 is held at the Data Archive under SN:1291.
Derivatives Of Benzopyrans Are Selective Estrogen Receptor Beta Agonists (Serbas): Molecular Modeling Study Of Benign Prostatic Hyperplasia
Creators: name: Gopalakrishna, Shreekara
name: Vastrad, Soumya
name: V Shakthi Dasan
name: K, Arun Kumar
name: Akinsanya M A
name: Bhatnagar, Jyoti
name: Naqvi, Asif
Publisher: name: Zenodo
Year: 2015
Subjects: Benign Prostatic Hyperplasia & Prostatic Carcinoma
SERBAs
Benzopyrans
Molecular Modelling
ADMET

description: Estrogen receptors play a significant role in the pathogenesis of prostate carcinoma (PCa) by estrogen signaling in normal and abnormal growth of the prostate gland. Estrogens directly target prostate tissue by specific estrogen receptors (ER). The human prostate is equipped with a dual system of ERs that undergoes profound remodeling during prostate cancer development and progression. It was reported that ER-beta may play a significant role in prostate cell differentiation and proliferation and may modulate both the initial phases of prostate carcinogenesis and androgen-independent tumor growth. A virtual screening and molecular docking study was conducted on 3500 benzopyrans for the development of new agonists for ER-beta. Molecular docking approach using Lamarckian Genetic Algorithm was carried out to find out the potent agonists for ER-beta on the basis of calculated ligand-protein pairwise interaction energies. The grid maps representing the protein were calculated using auto grid and grid size was set to 60*60*60 points with grid spacing of 0.375 Ǻ. Docking was carried out with standard docking protocol on the basis of a population size of 150 randomly placed individuals; a maximum number of 2.5 *107 energy evaluations, a mutation rate of 0.02, a crossover rate of 0.80 and an elitism value of 1. Ten independent docking runs were carried out for each ligand and results were clustered according to the 1.0 Ǻ RMSD criteria.

The docking result of the study of 3500 molecules demonstrated that the binding energies were in the range of -1.26 kcal/mol to -8.58 kcal/mol with the minimum binding energy of -8.58 kcal/mol. Three molecules showed promising ADMET properties.

Further in-vitro and in-vivo studies are required on these molecules as the binding mode provided hints for the future design of new inhibitors for ER-beta.
Service Business in Shopping Centres, 1979
Creators: name: Unit For Retail Planning Information Ltd
Publisher: name: UK Data Service
Year: 1981

description: The aim of this study was to provide planners and service branch operators with factual information on the main factors that affect the location and planning of service shops. More importantly, the study obtained shoppers reactions to the presence of the various types of services in centres and examined the relative use made of retail and service outlets in order to test various hypotheses on the role of services.
0063 Partnership between painters and sculptors in 17th-century Spain: on model drawings by Francisco Rizi for an altarpiece of the Expectant Virgin
Creators: name: Lamas-Delgado, Eduardo
Publisher: name: RIHA Journal
Year: 2013

description: This paper deals with a case study of the collaboration between sculptors and painters in the context of the construction of altarpieces in 17th-century Spain. It analyses a drawing by Francisco Rizi (Madrid, 1614-Escorial, 1685) in the British Museum depicting a sculptural group and fragments of an architectural framework, and relates it to two other drawings by the same artist in the National Library of Spain. They are identified as fragments of the design drawing of the former altarpiece of the Expectant Virgin in the church of the Calced Trinitarians in Madrid.
description: RIHA Journal, 2013: RIHA Journal
Simultaneous radiation pressure induced heating and cooling of an opto-mechanical resonator
Creators: name: Tallur, Siddharth
name: Bhave, Sunil A.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Cavity opto-mechanics enabled radiation-pressure coupling between optical and mechanical modes of a micro-mechanical resonator gives rise to dynamical backaction, enabling amplification and cooling of mechanical motion. Due to a combination of large mechanical oscillations and necessary saturation of amplification, the noise floor of the opto-mechanical resonator increases, rendering it ineffective at transducing small signals, and thereby cooling another mechanical resonance of the system. Here we show amplification of one mechanical resonance in a micro-mechanical ring resonator while simultaneously cooling another mechanical resonance by exploiting two closely spaced optical whispering gallery mode cavity resonances.
High Throughput Screen For Developmental Neurotoxicity Using Human Induced Pluripotent Stem Cell-Derived Neurons
Creators: name: Sirenko, Oksana
name: Cromwell, Evan F.
name: Parham, Fred
name: Holtz, Christian
name: Tice, Raymond R.
name: Behl, Mamta
name: Ryan, Kristen R.
Publisher: name: Zenodo
Year: 2015
Subjects: Screening
Developmental Neurotoxicity in Human Induced Pluripotent Stem Cell-Derived Neurons

description: There is an increased need to develop reliable and efficient screening tools to identify chemicals with the potential to adversely affect neurological development. Human iPSC-derived neurons exhibit the functionality and behavior of mature neurons and are available in quantities sufficient for screening workflows. We have developed imaging and analysis methods that provide tools for the assessment of multiple toxicity phenotypes using live neuronal cells. Phenotypic read-outs included characterization of neurite outgrowth, branching, number of processes, cell viability, and nuclear condensation. Since mitochondrial function has been associated with neuronal function we have tested changes of mitochondria membrane potential. In addition, we have evaluated processes of autophagy and mitophagy, characterized by co-localization of mitochondria and autophagy granules. Autophagosomes can be readily visualized and characterized even in heterogeneous cell populations using automated imaging and high-content analysis of live or fixed cells. Additional information can be obtained about the mechanisms of autophagic stimulation or inhibition by studying the co-localization of mitochondria or lysosomes with autophagosomes. Dose-response curves were generated from multiple data outputs on a cell-by-cell basis, allowing discrimination between simple cytotoxicity and specific effects on cellular function. To validate the assay, the library of 80 compounds was evaluated. The library contained compounds known to cause neurotoxicity, compounds of environmental concern, and compounds that serve as negative controls. Effects on neurite outgrowth and viable cell number were assessed following a 72 hr of exposure. Mitochondrial membrane potential (MMP) activity was evaluated in parallel following a 1 hour exposure. Compounds were ranked by activity and selectivity (i.e., compound specific effects on neurite outgrowth and mitochondria integrity independent of cytotoxicity). This strategy is useful for ranking compounds for potential neurotoxicity effects and aids in prioritization for more comprehensive in vivo assessments.
A Binary Shaped Mask Coronagraph for a Segmented Pupil
Creators: name: Enya, K.
name: Abe, L.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: We present the concept of a binary shaped mask coronagraph applicable to a telescope pupil including obscuration, based on previous works on binary shaped pupil mask by \citet{Kasdin2005} and \citet{Vanderbei1999}. Solutions with multi-barcode masks which "skip over" the obscuration are shown for various types of pupil of telescope, such as SUBARU, JWST, SPICA, and other examples. The number of diffraction tails in the point spread function of the coronagraphic image is reduced to two, thus offering a large discovery angle. The concept of mask rotation is also presented, which allows post-processing removal of diffraction tails and provides a 360$^{\circ}$ continuous discovery angle. It is suggested that the presented concept offers solutions which potentially allow large telescopes with segmented pupil in future to be used as platforms for an coronagraph.
description: 12 pages, 4 figures
Student Choice in Higher National Diploma Courses, 1979-1980
Creators: name: Freshwater, S.
Publisher: name: UK Data Service
Year: 1982

description: The number of students undertaking diploma courses in further education has expanded in recent years. In the light of this, the aims of the now completed project were to gain a better understanding of the bases upon which students opt for entry, and to look at student characteristics and drop-out in the first year of study.
 The courses, of two or three years' duration, that were selected for study were Computer Data Processing, Electrical and Electronic Engineering, and Chemistry, these subjects being regarded as particularly relevant in view of the national demand for qualified manpower in these areas. Initial exploratory interviews were supplemented by a survey of all entrants in Scotland for the academic session 1979/80.
Ideological Framework of Television News in Canada, 1980
Creators: name: Hackett, R., Queen's University (Kingston, Ontario), Department Of Political Studies
Publisher: name: UK Data Service
Year: 1982

description: This content data is part of a doctoral study on the ideological framework of television news in Canada, with particular focus on economic and industrial affairs. The hypothesis, broadly speaking, is that the `inferential framework' of the news will tend to support the legitimacy and intelligibility of capitalist social relations, and conversely to undermine political and economic challenges to those relations.
Spitzer IRS Spectral Mapping of the Toomre Sequence: Spatial Variations of PAH, Gas, and Dust Properties in Nearby Major Mergers
Creators: name: Haan, S.
name: Armus, L.
name: Laine, S.
name: Charmandaris, V.
name: Smith, J. D.
name: Schweizer, F.
name: Brandl, B.
name: Evans, A. S.
name: Surace, J. A.
name: Diaz-Santos, T.
name: Beirao, P.
name: Murphy, E. J.
name: Stierwalt, S.
name: Hibbard, J. E.
name: Yun, M.
name: Jarrett, T. H.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We have mapped the key mid-IR diagnostics in eight major merger systems of the Toomre Sequence (NGC4676, NGC7592, NGC6621, NGC2623, NGC6240, NGC520, NGC3921, and NGC7252) using the Spitzer Infrared Spectrograph (IRS). With these maps, we explore the variation of the ionized-gas, PAH, and warm-gas (H_2) properties across the sequence and within the galaxies. While the global PAH interband strength and ionized gas flux ratios ([Ne III]/[Ne II]) are similar to those of normal star forming galaxies, the distribution of the spatially resolved PAH and fine structure line flux ratios is significant different from one system to the other. Rather than a constant H_2/PAH flux ratio, we find that the relation between the H_2 and PAH fluxes is characterized by a power law with a roughly constant exponent (0.61+/-0.05) over all merger components and spatial scales. While following the same power law on local scales, three galaxies have a factor of ten larger integrated (i.e. global) H_2/PAH flux ratio than the rest of the sample, even larger than what it is in most nearby AGNs. These findings suggest a common dominant excitation mechanism for H_2 emission over a large range of global H_2/PAH flux ratios in major mergers. Early merger systems show a different distribution between the cold (CO J=1-0) and warm (H_2) molecular gas component, which is likely due to the merger interaction. Strong evidence for buried star formation in the overlap region of the merging galaxies is found in two merger systems (NGC6621 and NGC7592) as seen in the PAH, [Ne II], [Ne III], and warm gas line emission, but with no apparent corresponding CO (J=1-0) emission. Our findings also demonstrate that the variations of the physical conditions within a merger are much larger than any systematic trends along the Toomre Sequence.
description: 35 pages, accepted for publication in ApJS
0067 Miasta podwójne w państwie krzyżackim – przykład Torunia
Creators: name: Krantz-Domasłowska, Liliana
Publisher: name: RIHA Journal
Year: 2013

description: Toruń to pierwszy na terenie państwa krzyżackiego przykład miasta podwójnego. Wczesna, trzynastowieczna metryka Starego i Nowego Miasta skłania do pytania o przyczyny, jak i oczekiwania związane z lokacją nowego ośrodka. Kolejne takie układy w Elblągu, Braniewie, Królewcu i Gdańsku są późniejsze, każdy z nich prezentuje swoją indywidualną historię, a Toruń na tym tle szczególnie się wyróżnia. W tekście przywołuję kontekst historycznych uwarunkowań towarzyszących powstaniu toruńskiej aglomeracji, który staram się poszerzyć o czynniki artystyczne mogące uzupełnić wiedzę o relacjach między obydwoma miastami. Są to: układ urbanistyczny, topografia sakralna, formy i parametry głównych świątyń. Wszystkie te komponenty tworzą spójny obraz Nowego Miasta Torunia powiązanego ściśle z krzyżackim zarządcą.
description: RIHA Journal, 2013: RIHA Journal
Hans Dragendorff zum Gedächtnis
Creators: name: Krüger, Emil
Publisher: name: Trierer Zeitschrift - Archäologie und Kunst des Trierer Landes und seiner Nachbargebiete
Year: 2020

description: [nicht vorhanden]
description: Trierer Zeitschrift - Archäologie und Kunst des Trierer Landes und seiner Nachbargebiete, Bd. 15 (1940): Trierer Zeitschrift : für Geschichte und Kunst des Trierer Landes und seiner Nachbargebiete
High Content Assays For Characterizing The Viability And Morphology Of The 3D Cancer Spheroid Cultures
Creators: name: Sirenko, Oksana
name: Mitlo, Trisha
name: Cromwell, Evan
name: Hesley, Jayne
name: Windsor Owens
Publisher: name: Zenodo
Year: 2015
Subjects: cancer
3D models
spheroids
confocal imaging

description: There is an increasing interest in using three-dimensional (3D) spheroids for modelling cancer and tissue biology with the goal of accelerating translation research. The goal of this study was to develop high-content imaging and analysis methods to characterize phenotypic changes in human cancer spheroids in response to compounds treatment and to optimize spheroid assay protocols for higher throughput. Specifically, we optimized spheroid cell culture protocols using low adhesion 96- and 384-well plates for three commonly used cell lines, and improved the workflow with a one-step staining procedure that reduces assay time and minimizes variability. We improved imaging method by using maximum projection algorithm which allows combination of cellular information from multiple slices through 3D object into a single image that allows efficient comparison of spheroids with different phenotypes. Image analysis method provides multi-parametric characterization of single cell and spheroid phenotypes and can be extended to sub-cellular analysis. We report phenotypic readouts of cell scoring, quantification of cell numbers expressing different markers, measurement of cell viability and apoptosis, as well as characterization of spheroid size and shape. We assessed assay performance using established anti-cancer cytostatic and cytotoxic drugs, demonstrated concentration-response effects and measured IC50 values. The 3D spheroid results were compared to 2D cell cultures. Finally, we have screened a library of 119 approved anti-cancer drugs across wide range of concentrations using 116HTC spheroids. The proposed methods can increase throughput and performance of high-content assays for compound screening and fast evaluation of anti-cancer drugs with 3D cell models.
Phase-locked modulation delay between the poles of pulsar B1055-52
Creators: name: Weltevrede, Patrick
name: Wright, Geoff
name: Johnston, Simon
Publisher: name: arXiv
Year: 2012
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present a detailed single pulse study of PSR B1055-52 based on observations at the Parkes radio telescope. The radio emission is found to have a complex modulation dominated by a periodicity of ~20 times its rotational period P (0.197s), whose phase and strength depends on pulse longitude. This periodicity exhibits a phase-locked delay of about 2.5P between the main pulse (MP) and interpulse (IP), presumed to be the opposite poles of the pulsar. This delay corresponds to a light travel distance of many times the light cylinder radius. More complex modulations are found within the MP on timescales down to about 9P, and both these and the principal modulation vary strongly across the (at least) 7 components which the MP and IP exhibit. The nature of the single pulse emission, which ranges from smooth and longitudinally extended to `spiky', is also component-dependent. Despite these disparities, the total pulse intensity distributions at the MP and IP are virtually identical in shape, suggesting a common emission mechanism. In an attempt to account for the complex modulations we examine a number of physical models, both intrinsic (which presuppose the pulsar to be an isolated neutron star) and extrinsic (appealing to the presence of circumstellar material to modulate the emission). Significant objections can be made to each model, so this pulsar's behaviour patterns remain a crucial challenge to theorists.
description: 13 pages, 8 figures, submitted to MNRAS
Karl Waller, Der Urnenfriedhof in Wehden / Willi Wegewitz, Die Urnenfriedhöfe von Dohren und Daensen im Kreis Harburg
Creators: name: Hinz, Hermann
Publisher: name: Bonner Jahrbücher
Year: 2020

description: Rezension zu: Karl Waller, Der Urnenfriedhof in Wehden. Die Urnenfriedhöfe in Niedersachsen Bd. 4. Hildesheim 1961. 34 Seiten und 51 Tafeln. Willi Wegewitz, Die Urnenfriedhöfe von Dohren und Daensen im Kreis Harburg. Die Urnenfriedhöfe in Niedersachsen Bd. 5. Hildesheim 1961. 61 Seiten und 42 Tafeln.
description: Bonner Jahrbücher, Bd. 162 (1962): Bonner Jahrbücher
Stripped gas as fuel for newly formed HII regions in the encounter between VCC1249 and M49: a unified picture from NGVS and GUViCS
Creators: name: Battaia, Fabrizio Arrigoni
name: Gavazzi, Giuseppe
name: Fumagalli, Michele
name: Boselli, Alessandro
name: Boissier, Samuel
name: Cortese, Luca
name: Heinis, Sebastien
name: Ferrarese, Laura
name: Côté, Patrick
name: Mihos, J. Christopher
name: Cuillandre, Jean Charles
name: Duc, Pierre-Alain
name: Durrell, Patrick
name: Gwyn, Stephen
name: Jordán, Andrés
name: Liu, Chengze
name: Peng, Eric
name: Mei, Simona
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Context: We study the peculiar interacting galaxy system of VCC1249/M49 located in the core of the Virgo B subcluster. Owing to a recent interaction between the dwarf galaxy VCC1249 and the halo gas of the gE M49, neutral hydrogen has been displaced from the interstellar medium of this dwarf into the Virgo ICM. Observations also reveal multiple compact star-forming regions that are embedded in this HI cloud, with a projected separation up to 13 kpc from VCC1249 in the northwest direction. Aims: Motivated by recent NUV imaging from GUViCS of the VCC1249/M49 system that shows significant ongoing/recent star formation in the compact regions, we aim to constrain the origin of these outlying HII regions with a multi-wavelength approach. Methods: Using deep optical (u, g, i, z) imaging from NGVS and new Halpha imaging obtained at the San Pedro Martir observatory together with Keck long-slit spectroscopy, we characterize the SFR, ages, and metallicity of VCC1249 and its outlying compact regions. Moreover, we analyze the color and luminosity profile of the galaxy to investigate its recent interaction with M49. Results: Our new observations indicate that VCC1249 underwent a recent interaction with M49 in which both ram-pressure stripping and tidal interaction occured. The joint action of the two mechanisms led to the removal of the HI gas from the ISM of VCC1249, while the gravitational tides triggered the stellar tail and counter-tail of VCC1249. Our SED analysis reveals that the star formation in this galaxy was truncated around 200 Myr ago and that the outlying HII regions were born in situ about 10 Myr ago out of pre-enriched gas removed from the dwarf galaxy. These observations also reveal that interactions between central and satellite galaxies similar to the one between VCC1249/M49 may be an effective way of dispersing metals into the halos of massive galaxies.
description: 19 pages, 17 figures; one co-author added