cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
NuSTAR bounds on radiatively decaying particles from M82
Creators: name: Candón, Francisco R.
name: Fiorillo, Damiano F. G.
name: Lucente, Giuseppe
name: Vitagliano, Edoardo
name: Vogel, Julia K.
Publisher: name: arXiv
Year: 2024
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Axions and other putative feebly interacting particles (FIPs) with a mass of tens to several hundreds of keVs can be produced in stellar cores with a Lorentz boost factor $E_a/m_a\lesssim 10$. Thus, starburst galaxies such as M82 are efficient factories of slow axions. Their decay $a\rightarrowγγ$ would produce a large flux of X-ray photons, peaking around $100$ keV and spread around the galaxy by an angle that can be relatively large. We use observations of the Nuclear Spectroscopic Telescope Array (NuSTAR) mission to show that the absence of these features can constrain $30-500$ keV axion masses into uncharted regions for axion-photon coupling of $g_{aγ}\sim 10^{-10}-10^{-12}\,\rm GeV^{-1}$. Our argument can be applied to other heavy FIPs and astrophysical sources that are hot enough to produce them, yet cold enough to avoid large boost factors which slow down the decay.
description: 4 pages, 3 figures, plus Supplemental Material
Senn, Guebhard & Co., in Liquidation
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1825

description: Ort: Livorno
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
SHPO-CON-471: Re: Section 106 Consultation for Site 32 Cluster Remediation Project, Vandenberg AFB (your letter of March 28, 2018 and e-mail of April 25, 2018)
Creators: name: Polanco, Julianne
Year: 2018

description: This document is a State Historic Preservation Office (SHPO) concurrence letter for the Site 32 Cluster Remediation Project on Vandenberg Air Force Base, California. The SHPO concurred with the finding of no adverse effect for the project.
Back to the Future: The Role of Possible Selves in Developing a Physical Activity Identity in Newly Retired Individuals
Creators: name: Perras, Mélanie G.M.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Retirement
Retirees
Physical activity
Self
Self-perceptions
Possible selves
Identity
Intervention

description: Retirement affords retirees increased time for participation in salutary activities like physical activity. Yet, evidence is mixed as to whether or not retirees use this time to increase their participation in physical activity. Greater knowledge of the factors affecting physical activity participation in retirement is needed. Retirement is also a life transition ripe with opportunity to redefine one's identity and place greater attention on health-enhancing behaviours. Thereupon, this dissertation was rooted in the self literature, as self perceptions such as identity and possible selves may be particularly relevant for understanding physical activity in retired individuals. As a result, the first aim of this dissertation sought to confirm, in a preliminary study (Study 1), the relationship between possible selves, physical activity identity and physical activity in retirees. Through questionnaire data collected concurrently, Study 1 showed that identity and possible selves were related to physical activity (Article 1). Moreover, positive associations were found between possible selves focused on physical activity and physical activity identity. Subsequently, the relationships between these variables were further probed to determine whether exercise identity mediated the relationship between physical activity possible selves and physical activity (Article 2). Questionnaire data collected across three time points (one month apart) showed that identity mediated the relationship between possible selves and behaviour - all related to physical activity. Together, these findings represented an important first step toward designing a relevant intervention for retirees which informed the second aim of this dissertation (Study 2). A possible selves intervention designed to increase physical activity identity and physical activity was tested (Article 3). Changes in these variables were compared across three groups of an experimental design: a repeated possible selves intervention, a one-time possible selves intervention, and a control group. All groups reported marginally higher levels of physical activity and physical activity identity, inconsequential to group assignment. Overall, the present dissertation makes contributions to the self literature especially with regards to new retirees. Nevertheless, limitations are acknowledged and discussed. Finally, future research avenues are presented.
Tavel, Auguste
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1825

description: Ort: Payerne
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
"Tante Netty" / "Tante Nelly" an Anna Ulrich
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1900

description: Enthält zwei Postkarten von "Tante Netty" oder "Tante Nelly" an Anna Ulrich vom 02.11.1900 und vom 15.12.1900.
Sevin, J. N., Spitalapotheker
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1825

description: Ort: Königsfelden / Brugg
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Schulthess, Caspar, Erben
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1825

description: Ort: Zürich
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Steiner, Diethelm
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1825

description: Ort: Bergamo
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
A Novel Road Marking Detection and Recognition Technique Using a Camera-based Advanced Driver Assistance System
Creators: name: Tang, Zongzhi
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: ADAS
Line Detection
Marking Detection

description: Advanced Driver Assistance System (ADAS) was widely learned nowadays. As crucial parts of ADAS, lane markings detection, as well as other objects detection, have become more popular than before. However, most methods implemented in such areas cannot perfectly balance the performance of accuracy versus efficiency, and the mainstream methods (e.g. Machine Learning) suffer from several limitations which can hardly break the wall between partial autonomous and fully autonomous driving. This thesis proposed a real-time lane marking detection framework for ADAS, which included 4-extreme points set descriptor and a rule-based cascade classifier. By analyzing the behavior of lane markings on the road surface, a characteristic of markings was discovered, i.e., standard markings can sustain their shape in the perpendicular plane of the driving direction. By employing this feature, a 4-extreme points set descriptor was applied to describe the shape of each marking first. Specifically, after processing Maximally Stable Extremal Region (MSER) and Hough transforms on a 2-D image, several contours of interest are obtained. A bounding box, with borders parallel to the image coordinate, intersected with each contour at 4 points in the edge, which was named 4-extreme points set. Afterward, to verify consistency of each contour and standard marking, some rules abstracted from construction manual are employed such as Area Filter, Colour Filter, Relative Location Filter, Convex Filter, etc. To reduce the errors caused by changes in driving direction, an enhanced module was then introduced. By tracking the vanishing point as well as other key points of the road net, a method for 3-D reconstruction, with respect to the optical axis between vanishing point and camera center, is possible. The principle of such algorithm was exhibited, and a description about how to obtain the depth information from this model was also provided. Among all of these processes, a key-point based classification method is the main contribution of this paper because of its function in eliminating the deformation of the object caused by inverse perspective mapping. Several experiments were conducted in highway and urban roads in Ottawa. The detection rate of the markings by the proposed algorithm reached an average accuracy rate of 96.77% while F1 Score (harmonic mean of precision and recall) also attained a rate of 90.57%. In summary, the proposed method exhibited a state-of-the-art performance and represents a significant advancement of understanding.
Staehelin, Balthasar, de Benedict
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1825

description: Ort: Basel
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Schmid, J. J., I.U.L
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1825

description: Ort: Basel
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Sillem, Benecke & Co
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1825

description: Ort: Hamburg
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Sperry, Jacob
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1825

description: Ort: Philadelphia
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
"Hier schläft der Barde" : für 4stimmigen Männerchor
Creators: name: Reiter, Ernst
name: Moore, Thomas
Publisher: name: [s.n.]
Year: 1843

description: von Ernst Reiter ; [Text] nach dem Englischen von Thomas Moore
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire 2009 Übernahme Rekatalogis. AK UB durch Medea 2002-2005
description: Digitalisierung=Digitization=Numérisation April 2024 TIFF
Supplementary Material for “Image-driven classification of functioning and nonfunctioning pituitary adenoma by deep convolutional neural networks”
Creators: name: Hongyu Li
name: Zhao, Qi
name: Yihua Zhang
name: Sai, Ke
name: Lunshan Xu
name: Yonggao Mou
name: Yubin Xie
name: Ren, Jian
name: Xiaobing Jiang
Publisher: name: figshare
Year: 2020
Subjects: subject: 111202 Cancer Diagnosis
subject: FOS: Clinical medicine

description: Supplementary Material for “Image-driven classification of functioning and nonfunctioning pituitary adenoma by deep convolutional neural networks”
Personalized Head-Related Transfer Function Prediction Based on Spatial Grouping
Creators: name: Chang, Keng-Wei
name: Shen, Yih-Liang
name: Chi, Tai-Shi
Publisher: name: arXiv
Year: 2024
Subjects: subject: Signal Processing (eess.SP)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: The head-related transfer function (HRTF) characterizes the frequency response of the sound traveling path between a specific location and the ear. When it comes to estimating HRTFs by neural network models, angle-specific models greatly outperform global models but demand high computational resources. To balance the computational resource and performance, we propose a method by grouping HRTF data spatially to reduce variance within each subspace. HRTF predicting neural network is then trained for each subspace. Simulation results show the proposed method performs better than global models and angle-specific models by using different grouping strategies at the ipsilateral and contralateral sides.
Post-Weld Heat Treatment of API 5L X70 High Strength Low Alloy Steel Welds
Creators: name: Alipooramirabad, Houman
name: Paradowska, Anna
name: Nafisi, Shahrooz
name: Reid, Mark
name: Ghomashchi, Reza
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2021

description: High Strength Low Alloy (HSLA) steels are the materials of choice in pipeline construction with the API X70 grade as the steel for the majority of pipeline networks constructed during the late 20th and early this century. This paper reports on the influence of Post-Weld Heat Treatment (PWHT) on the reduction of residual stresses, resulting changes in the microstructure, and mechanical properties of a multi-pass, X70 HSLA steel, weld joints made by a combined Modified Short Arc Welding (MSAW) and Flux Cored Arc Welding (FCAW) processes. Neutron diffraction results highlighted high magnitude of tensile residual stresses, in excess of yield strength of both parent and weld metal, in the as-welded specimen (~650 MPa), which were decreased substantially as a result of applying PWHT (~144 MPa). Detailed microstructural studies are reported to confirm the phase transformation during PWHT and its interrelationship with mechanical properties. Transmission Electron Microscopy (TEM) analysis showed polygonization and formation of sub-grains in the PWHT specimen which justifies the reduction of residual stress in the heat-treated weld joints. Furthermore, microstructural changes due to PWHT justify the improvement in ductility (increase in the elongations) with a slight reduction in yield and tensile strength for the PWHT weld joint.
Plotting Crime: Comparing Representations of the Spatial Distribution of Crime in an Urban Context
Creators: name: Yaraskovitch, Alyson A.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: crime
criminology
geography
Ottawa
mixed methods
qualitative
map
GIS

description: Over the past few decades, research into public perceptions of crime has largely focused on how mass media consumption shapes beliefs about crime. Substantially less research has been dedicated to exploring the potential influence of alternative sources of information, and even less attention has been devoted to exploring the spatiotemporal aspect of perceptions of crime. This thesis combined Geographic Information Systems (GIS) and structured interviews in order to explore the narratives about crime constructed by three sources: (1) the Ottawa Police Service, (2) the Ottawa Citizen newspaper, and (3) residents of Ottawa. Eight participants were taken on a walking tour interview, and their responses were compared to two maps depicting the geographies of crime presented by the Ottawa Police Service and the Ottawa Citizen. It was found that the places participants believed to be criminal ones were poorly maintained and dirty, were populated by large numbers of homeless individuals, had little to no commercial space, were geographically close to other areas of the city believed to be criminal spaces, and were poorly lit. The three construction of the spatial distribution of crime in Ottawa shared many common features (such as a focus on the Byward Market area as highly criminal) while remaining distinct in their presentation of certain types of spaces (such as the newspaper’s presentation of homeless shelters as highly criminal spaces). Ultimately, this thesis explores three distinct narratives about the geography of crime in Ottawa through the use of a unique mixed methods design that provides an alternative way of interpreting data most commonly analyzed through deductive or quantitative means.
High-contrast absorption magnetometry in the visible to near-infrared range with nitrogen-vacancy ensembles
Creators: name: Schall, Florian
name: Hahl, Felix A.
name: Lindner, Lukas
name: Vidal, Xavier
name: Luo, Tingpeng
name: Zaitsev, Alexander M.
name: Ohshima, Takeshi
name: Jeske, Jan
name: Quay, Rüdiger
Publisher: name: arXiv
Year: 2024
Subjects: subject: Applied Physics (physics.app-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Magnetometry with nitrogen-vacancy (NV) centers has so far been measured via emission of light from NV centers or via absorption at the singlet transition at 1042 nm. Here, we demonstrate a phenomenon of broadband optical absorption by the NV centers starting in the emission wavelength and reaching up to 1000 nm. The measurements are enabled by a high-finesse cavity, which is used for room temperature continuous wave pump-probe experiments. The red to infrared probe beam shows the typical optically detected magnetic resonance (ODMR) signal of the NV spin with contrasts up to 42 %. This broadband optical absorption is not yet reported in terms of NV magnetometry. We argue that the lower level of the absorbing transition could be the energetically lower NV singlet state, based on the increased optical absorption for a resonant microwave field and the spectral behavior. Investigations of the photon-shot-noise-limited sensitivity show improvements with increasing probe wavelength, reaching an optimum of 7.5 pT/$\sqrt{\mathrm{Hz}}$. The results show significantly improved ODMR contrast compared to emission-based magnetometry. This opens a new detection wavelength regime with coherent laser signal detection for high-sensitivity NV magnetometry.
description: 11 pages, 4 figures
Tantum ergo : für Gemischten Chor
Creators: name: Ammann, Benno
Publisher: name: [s.n.]
Year: 1953

description: Benno Ammann
description: Dauer: ca. 2 min
description: a) Partitur-Entwurf (Bleistift), teilweise textiert, datiert: 29.6.[19]53. - 1 Bl. ; 21 cm quer
description: b) Skizze (Bleistift), datiert: 29.6.[19]53. - 2 Bl. ; 26 cm##Enthält: Skizzen zu einem Gloria und zu einem Benedictus
description: Öffentliche Bibliothek der Universität Basel
description: Latein
Harnessing Oncolytic Virus-mediated Anti-tumour Immunity
Creators: name: Lemay, Chantal
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: Oncolytic Virus
Cancer
Immunotherapy
Vaccine

description: Treatment of permissive tumours with the oncolytic virus (OV) VSV-Δ51 leads to a robust anti-tumour T cell response, which contributes to efficacy; however, many tumours are not permissive to in vivo treatment with VSV-Δ51. In an attempt to channel the immune stimulatory properties of VSV-Δ51 and broaden the scope of tumours that can be treated by an OV, a potent oncolytic vaccine platform was developed, consisting of tumour cells infected with VSV-Δ51. I demonstrate that prophylactic immunization with this infected cell vaccine (ICV) protected mice from subsequent tumour challenge, and expression of GM-CSF by the virus (VSVgm-ICV) increased efficacy. Immunization with VSVgm-ICV in the VSV-resistant B16-F10 model induced maturation of dendritic cells, natural killer (NK) cells, and T cells. I demonstrate that this approach is robust enough to control the growth of established and spontaneous tumours. This strategy is broadly applicable because of VSV’s extremely broad tropism, allowing nearly all cell types to be infected at high MOIs in vitro, where the virus replication kinetics outpace the cellular IFN response. It is also personalized to the unique tumour antigen(s) displayed by the cancer cell. Histone deacetylase inhibitors (HDIs) can augment viral replication, making them particularly interesting complements to OV therapy. However, the impact of HDIs on the generation and re-stimulation of immune responses remains to be clearly elucidated. Along with my collaborators at McMaster University, I demonstrate that MS-275, but not SAHA, selectively depletes naïve and regulatory lymphocytes. Memory lymphocytes that are being boosted remain unscathed and even have enhanced cytokine production, potentially as a consequence of the depleted lymphocyte compartment. This leads to a delay in anti-VSV neutralizing antibodies and T cell responses. Interestingly, HDI treatment of B16-F10 cells appears to inhibit VSV replication but allows for a longer persistence within the tumour. When used in an oncolytic prime/boost vaccination model, MS-275 potently enhanced survival. Though the anti-tumour immune response is enhanced, a near complete reduction in autoimmune vitiligo is observed with MS-275 administration. Therefore, this HDI uniquely modulates the immune response to enhance anti-tumour immunity and decrease the anti-viral response, while also decreasing autoimmune sequelae.
3 Lieder : [für eine Singstimme mit Klavier]
Creators: name: Fröhlich, Friedrich Theodor
name: Tieck, Ludwig
name: Randhartinger, Benedict
name: Corrodi, Carl
Publisher: name: [s.n.]
Year: 1822

description: [Friedrich Theodor Fröhlich]
description: "Scherz": siehe auch kr XI 119 (S. 100) ; "Schifferlied der Wasserfee": Begleitung nicht fertig. Vollst. siehe kr XI 119 (S. 101)
description: Geschenk 1927 *27.932 Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire 2010 Übernahme Rekatalogis. AK UB durch Medea 2002-2005
description: Digitalisierung=Digitization=Numérisation Juni 2024 TIFF
HfO$_2$-based platform for high-index-contrast visible/UV integrated photonics
Creators: name: Jaramillo, Oscar
name: Natarajan, Vighnesh
name: Rivy, Hamim Mahmud
name: Tensuan, Joshua
name: Massai, Leonardo
name: Mehta, Karan K.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Ultraviolet and visible integrated photonics are enabling for applications in quantum information, sensing, and spectroscopy, among others. Few materials support low-loss photonics into the UV, and the relatively low refractive index of known depositable materials limits the achievable functionality. Here we present a high-index integrated photonics platform based on HfO$_2$ and Al$_2$O$_3$ composites deposited via Atomic Layer Deposition (ALD) with low loss in the visible and near-UV. We show that Al$_2$O$_3$ incorporation dramatically decreases bulk loss compared to pure HfO$_2$, consistent with inhibited crystallization due to the admixture of Al$_2$O$_3$. Composites exhibit refractive index $n$ following the average of that of HfO$_2$ and Al$_2$O$_3$, weighted by the HfO$_2$ fractional composition $x$. At $λ=375$ nm, composites with $x=0.67$ exhibit $n=2.08$ preserving most of HfO$_2$'s significantly higher index, and $3.8(7) $ dB/cm material loss. We further present fully etched and cladded waveguides, grating couplers, and ring resonators, realizing single-mode waveguide loss of $0.25(2)$ dB/cm inferred from resonators of 2.6 million intrinsic quality factor at $λ=729$ nm, $2.6(2)$ dB/cm at $λ=405$ nm, and $7.7(6)$ dB/cm at $λ=375$ nm. We measure the composite's thermo-optic coefficient (TOC) to be $2.44(3) \times 10^{-5}$ RIU/$^\circ$C near $λ=397$ nm. This work establishes (HfO$_2$)$_x$(Al$_2$O$_3$)$_{1-x}$ composites as a platform amenable to integration for low-loss, high-index photonics spanning the UV to NIR.
Whigs, Tories, and the Taxation of Augustan England, 1689-1715
Creators: name: Walsh, Christopher
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: England
Britain
Land Tax
Fiscal-Military
Rage of Party
Whig
Tory
politics

description: After the Glorious Revolution of 1688 the divisions within English society found additional expression through political parties as contemporaries staked out ideological positions on numerous issues and crises facing the nation. While the parties fought over issues of sovereignty and governance, the development of a taxation regime, required to pursue and support the nation’s almost constant wars on the continent, was also drawn into this contest. The nature of the debates over taxation on landed property provides an important lens through which to understand the ideological positions of both Whigs and Tories over matters of not only political economy, but religion, society, and governance. The English Land Tax, is one of the most important fiscal instruments of Augustan England and reveals how Whigs and Tories articulated positions on the aftermath of 1689, on the financial revolution that followed, and on the nature of governance at the beginning of the ‘long eighteenth century.’
Contact Resistance Optimization in MoS${_2}$ Field-Effect Transistors through Reverse Sputtering-Induced Structural Modifications
Creators: name: Fa, Yuan
name: Piacentini, Agata
name: Macco, Bart
name: Kalisch, Holger
name: Heuken, Michael
name: Vescan, Andrei
name: Wang, Zhenxing
name: Lemme, Max C.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Two-dimensional material (2DM)-based field-effect transistors (FETs), such as molybdenum disulfide (MoS${_2}$)-FETs, have gained significant attention for their potential for ultra-short channels, thereby extending Moore's law. However, MoS${_2}$-FETs are prone to the formation of Schottky barriers at the metal-MoS${_2}$ interface, resulting in high contact resistance (R${_c}$) and, consequently, reduced transistor currents in the ON-state. Our study explores the modification of MoS${_2}$ to induce the formation of conductive 1T-MoS${_2}$ at the metal-MoS${_2}$ interface via reverse sputtering. MoS${_2}$-FETs exposed to optimized reverse sputtering conditions in the contact area show R${_c}$ values reduced to less than 50% of their untreated counterparts. This reduction translates into improvements in other electrical characteristics, such as higher ON-state currents. Since reverse sputtering is a standard semiconductor process that enhances the electrical performance of MoS${_2}$-FETs, it has great potential for broader application scenarios in 2DM-based microelectronic devices and circuits.
description: 33 pages
Examining Methods and Practices of Source Data Verification in Canadian Critical Care Randomized Controlled Trials
Creators: name: Ward, Roxanne E.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: source data verification
quality assurance
data management
monitoring

description: Statement of the Problem: Source data verification (SDV) is the process of comparing data collected at the source to data recorded on a Case Report Form, either paper or electronic (1) to ensure that the data are complete, accurate and verifiable. Good Clinical Practice (GCP) Guidelines are vague and lack evidence as to the degree of SDV and whether or not SDV affects study outcomes. Methods of Investigation: We performed systematic reviews to establish the published evidence-base for methods of SDV and to examine the effect of SDV on study outcomes. We then conducted a national survey of Canadian Critical Care investigators and research coordinators regarding their attitudes and beliefs regarding SDV. We followed by an audit of the completed and in-progress Randomized Controlled Trials (RCTs) of the Canadian Critical Care Trials Group (CCCTG). Results: Systematic Review of Methods of SDV: The most common reported or recommended frequency of source data verification (10/14 - 71%) was either based on level or risk, or that it be conducted early (i.e. after 1st patient enrolled). The amount of SDV recommended or reported, varied from 5-100%. Systematic Review of Impact of SDV on Study Outcomes: There was no difference in study outcomes for 1 trial and unable to assess in the other. National Survey of Critical Care Investigators and Research Coordinators: Data from the survey found that 95.8% (115/120) of respondents believed that SDV was an important part of Quality Assurance; 73.3% (88/120) felt that academic studies should do more SDV; and 62.5% (75/120) felt that there is insufficient funding available for SDV. Audit of Source Data Verification Practices in CCCTG RCTs: In the national audit of in-progress and completed CCCTG RCTs, 9/15 (60%) included a plan for SDV and 8/15 (53%) actually conducted SDV. Of the 9 completed published trials, 44% (4/9) conducted SDV. Conclusion: There is little evidence base for methods and effect of SDV on study outcomes. Based on the results of the systematic review, survey, and audit, more research is needed to support the evidence base for the methods and effect of SDV on study outcomes.
Mazurka : [für Klavier]
Creators: name: Reiter, Ernst
Publisher: name: [s.n.]
Year: 1840

description: Ernst Reiter
description: Geschenk 1935 *35.2471 Öffentliche Bibliothek der Universität Basel
description: Verzeichnung=Description=Inventaire 2009 Übernahme Rekatalogis. AK UB durch Medea 2002-2005
description: Digitalisierung=Digitization=Numérisation Mai 2024 TIFF
Evaluation of the Altered Pathophysiological Mechanism of the Human Arg302Gln-PRKAG2 Mutation-Induced Metabolic Cardiomyopathy: Studying the Glucose Metabolism Pathway in a Transgenic Mouse Model
Creators: name: Thorn, Stephanie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Patlak
Positron emission tomography
FDG
glycogen
trimetazidine
echocardiography

description: Characterized by excessive myocardial glycogen deposition, cardiac hypertrophy, frequent cardiac arrhythmias and progressive conduction system disease, the PRKAG2 cardiac syndrome stems from a genetic mutation in the γ2-subunit of AMP-activated protein kinase (AMPK). Although functionally diverse, the main role of AMPK is to modulate cardiac metabolism in response to depleted ATP levels. A comprehensive study of the dysfunctional regulation of AMPK activity involved in the progression of the human PRKAG2 cardiac syndrome is hindered by the limitations of in vitro techniques. Positron emission tomography (PET) imaging with the glucose analogue, FDG, offers a quantitative assessment of myocardial glucose uptake non-invasively. The aim of this thesis was to determine the ability of FDG to detect changes in glucose uptake, storage and metabolism in the heart in relation to AMPK activity and provide insights into the mechanism of PRKAG2 cardiac hypertrophy. To achieve this aim, a transgenic AMPK γ2-subunit Arg302Gln mouse model was evaluated with small animal FDG PET with correlation to biochemical assays of cardiac AMPK activity and the glycogen metabolism pathway. Using the vena cava blood input function, FDG myocardial glucose uptake was reliably assessed in mice for the first time with Patlak modeling. Reduced FDG uptake in the Arg302Gln PRKAG2 mouse model suggested a feedback pathway reducing exogenous glucose uptake due to excessive intracellular glycogen stores. Despite an increase in FDG uptake in the skeletal muscle of the PRKAG2 mutant mice following insulin stimulation, there was no change in cardiac uptake, signifying myocardial insulin resistance. Increased reliance on glucose oxidation by TMZ inhibition of fatty acid oxidation reduced glycogen stores, restored cardiac function and eliminated ventricular preexcitation. The observed reduction in mouse myocardial FDG uptake mirrors the reduction previously observed in the human PRKAG2 patients. The potential now exists to evaluate both progression and therapeutic interventions for the PRKAG2 cardiac syndrome with the transgenic mouse model with translation to the affected patients using FDG cardiac imaging.
Adagio für Violine und Flöte
Creators: name: Fröhlich, Friedrich Theodor
Publisher: name: [s.n.]
Year: 1803

description: [Friedrich Theodor Fröhlich]
description: Geschenk 1927 *27.932 Öffentliche Bibliothek der Universität Basel
description: hss Notiz: Vermutlich Orchesterstimmen 26. 6. 86 / hm (12.05.2011/BS UB/JPL)
description: Digitalisierung=Digitization=Numérisation Juni 2024 TIFF
description: Verzeichnung=Description=Inventaire 2009 Übernahme Rekatalogis. AK UB durch Medea 2002-2005
Both Feast & Famine: The Historical Legitimacy of the Right to Food in Addressing Overnutrition
Creators: name: Houston, Adam R
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Right to Food
Malnutrition
Human Rights
Overnutrition
Obesity

description: Hunger and obesity might initially appear fundamentally opposite conditions. Per Olivier de Schutter, then UN Special Rapporteur on the Right to Food, in his 2011 report to the UN Human Rights Council, they are both manifestations of malnutrition resulting from the failure to realize the Right to Food. This marked the first high-profile description of overnutrition as a counterpart to undernutrition in the context of the Right to Food. This paper argues that this interpretation is both logical and has historical legitimacy. A review of the history of both the Right to Food and concepts of nutrition at the international level underscores that malnutrition has a broader meaning than simply minimum caloric intake. Earlier interpretations of the right emphasizing starvation and chronic hunger have reflected the predominant concerns of their times. Today, those concerns have shifted; more people worldwide are obese than are underweight, and more deaths worldwide are linked to overnutrition than undernutrition. This rise in mortality is accompanied by growing understanding that overnutrition, like undernutrition, is heavily influenced by factors under state rather than individual control. In turn, the emerging double burden of overnutrition and undernutrition in many communities underscores the fact that these two serious concerns are both facets of the same underlying issue. By demonstrating the legitimacy of addressing overnutrition from a Right to Food perspective, it is hoped that this paper will highlight a potentially useful advocacy tool for promoting effective legal and policy solutions to a serious global issue.
Wired high rise: constructing a virtual community in an inner city housing estate
Creators: name: Meredyth, Denise
name: Thomas, Julian
name: Ewing, Scott
name: Hopkins, Liza
Publisher: name: Swinburne
Year: 2024

description: This paper explores the evolving connections between information and social policy through the construction of ‘Reach for the Clouds’, a ‘networked community’ in Atherton Gardens, a high rise housing estate in Melbourne, Australia. The project was developed by the InfoXchange, an internet service provider with a ‘social entrepreneurial’ orientation. It also involves a consortium of government and community groups and draws on a combination of voluntary labour, commercial enterprise, government funding and donations of equipment by local businesses. We give a brief description of the project and its protagonists, consider the motivations behind the network, and the difficulties which lie in evaluating such a project. [Introduction]
2 Lieder : [für eine Singstimme mit Klavier]
Creators: name: Fröhlich, Friedrich Theodor
name: Hessemer, Friedrich Maximilian
name: Tanner, Karl Rudolf
Publisher: name: [s.n.]
Year: 1803

description: [Friedrich Theodor Fröhlich]
description: Geschenk 1927 *27.932 Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire 2010 Übernahme Rekatalogis. AK UB durch Medea 2002-2005
description: Digitalisierung=Digitization=Numérisation Juni 2024 TIFF
Toward ultimate-efficiency frequency conversion in nonlinear optical microresonators
Creators: name: Wang, Zhi-Yan
name: Wu, Xiao
name: Xiong, Xiao
name: Yang, Chen
name: Hao, Zhengzhong
name: Yang, Qi-Fan
name: Hu, Yaowen
name: Bo, Fang
name: Cao, Qi-Tao
name: Xiao, Yun-Feng
Publisher: name: arXiv
Year: 2024
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Integrated nonlinear photonics has emerged as a transformative platform, enabling nanoscale nonlinear optical processes with significant implications for sensing, computation, and metrology. Achieving efficient nonlinear frequency conversion in optical microresonators is paramount to fully unlocking this potential, yet the absolute conversion efficiency (ACE) of many processes, such as second-harmonic generation (SHG), remains fundamentally constrained by dissipative losses and intrinsic nonlinear effects in the device. In this work, we establish a unified theoretical framework for SHG in microresonators, identifying a decisive factor M that predicts the upper limit of ACE under the nonlinear critical coupling (NCC) condition. Using this framework, we fabricate integrated periodically poled lithium niobate microresonators and address the dispersive and dissipative suppression to approach the NCC condition. We achieve a record-high experimental ACE of 61.3% with milliwatt-level pump powers toward the ultimate efficiency, with the potential for even higher efficiency as the M factor increases. These results provide a versatile paradigm for high-efficiency nonlinear optical devices, offering new opportunities for advancements across classical and quantum photonic applications.
Nachtmusik : Drei Notturni für Klavier und Geige
Creators: name: Fröhlich, Friedrich Theodor
Publisher: name: [s.n.]
Year: 1823

description: [Friedrich Theodor Fröhlich]
description: Datiert: Berlin 1823 und Anfang 1824
description: Geschenk 1927 *27.932 Öffentliche Bibliothek der Universität Basel
description: Verzeichnung=Description=Inventaire 2009 Übernahme Rekatalogis. AK UB durch Medea 2002-2005
description: Digitalisierung=Digitization=Numérisation Juni 2024 TIFF
Environmentally Harmful Subsidies In Germany 2014
Creators: name: Burger, Andreas
name: Köder, Lea
name: Eckermann, Frauke
Publisher: name: My University
Year: 2014
Subjects: subject: Umweltschädliche Subvention
subject: Umweltbelastung
subject: Bundesrepublik Deutschland
subject: reduction of environmentally harmful subsidies
subject: environmental impact of subsidies
subject: Economy | Consumption

description: In 2010 environmentally harmful subsidies in Germany amounted to more than €52 billion. The state granted subsidies among others to the lignite industry and aviation sector. The volume of subsidies therefore remains high - and there is no sign of a systematic reduction. Environmentally harmful subsidies not only thwart environmental protection, they are also a burden on public funds. A reduction would create the financial means for the state to shape a sustainable policy, for example for the benefit of climate protection or to modernize transport infrastructure. In its updated edition of the "Environmentally Harmful Subsidies in Germany" report the Federal Environment Agency recommends that these subsidies be systematically reduced without delay.
Quelle: www.umweltbundesamt.de

description: In 2010 environmentally harmful subsidies in Germany amounted to more than €52 billion. The state granted subsidies among others to the lignite industry and aviation sector. The volume of subsidies therefore remains high –  and there is no sign of a systematic reduction. Environmentally harmful subsidies not only thwart environmental protection, they are also a burden on public funds. A reduction would create the financial means for the state to shape a sustainable policy, for example for the benefit of climate protection or to modernize transport infrastructure. In its updated edition of the "Environmentally Harmful Subsidies in Germany" report the Federal Environment Agency recommends that these subsidies be systematically reduced without delay.
The Evolution of the Intestinal Microbiome of Premature Infants and Piglets Receiving Probiotics and Lactoferrin
Creators: name: Grzywacz, Kelly
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Microbiome
Probiotic
Lactoferrin
Premature Infants

description: Probiotics and lactoferrin are currently being used in neonatal intensive care units in the hopes of reducing rates of sepsis and necrotizing enterocolitis. While studies have shown that these measures can be clinically beneficial to premature babies, little is known about their effect at the level of the intestinal microbiome. We performed a prospective study describing the composition and evolution of the microbiota of premature babies receiving probiotics with and without lactoferrin supplementation. Furthermore, we compared our findings to a piglet model. We found that the addition of lactoferrin did not lead to a distinct microbiome using UniFrac analysis, nor increased diversity or richness as compared to probiotics alone. The relative abundance of probiotic bacterial strains was approximately 3%. At the phylum level Firmicutes and Proteobacteria predominated, while overall Enterobacteriaceae was the most abundant family. We remain the first to describe the microbiome of premature infants receiving lactoferrin.
Lipidation of Antimicrobial Peptides as a Design Strategy for Future Alternatives to Antibiotics
Creators: name: Rounds, Taylor
name: Straus, Suzana
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2021

description: Multi-drug-resistant bacteria are becoming more prevalent, and treating these bacteria is becoming a global concern. One alternative approach to combat bacterial resistance is to use antimicrobial (AMPs) or host-defense peptides (HDPs) because they possess broad-spectrum activity, function in a variety of ways, and lead to minimal resistance. However, the therapeutic efficacy of HDPs is limited by a number of factors, including systemic toxicity, rapid degradation, and low bioavailability. One approach to circumvent these issues is to use lipidation, i.e., the attachment of one or more fatty acid chains to the amine groups of the N-terminus or a lysine residue of an HDP. In this review, we examined lipidated analogs of 66 different HDPs reported in the literature to determine: (i) whether there is a link between acyl chain length and antibacterial activity; (ii) whether the charge and (iii) the hydrophobicity of the HDP play a role; and (iv) whether acyl chain length and toxicity are related. Overall, the analysis suggests that lipidated HDPs with improved activity over the nonlipidated counterpart had acyl chain lengths of 8–12 carbons. Moreover, active lipidated peptides attached to short HDPs tended to have longer acyl chain lengths. Neither the charge of the parent HDP nor the percent hydrophobicity of the peptide had an apparent significant impact on the antibacterial activity. Finally, the relationship between acyl chain length and toxicity was difficult to determine due to the fact that toxicity is quantified in different ways. The impact of these trends, as well as combined strategies such as the incorporation of d- and non-natural amino acids or alternative approaches, will be discussed in light of how lipidation may play a role in the future development of antimicrobial peptide-based alternatives to current therapeutics.
Comparing PTT and General Relativity: The Foundational Role of Trelax
Creators: name: Allou, Essam
Publisher: name: Zenodo
Year: 2025
Subjects: subject: Pure Time Theory
subject: PTT
subject: Trelax
subject: General Relativity
subject: GR
subject: Temporal Scalar Field
subject: Ontology of Time
subject: Time Dilation
subject: Quantum Unification
subject: Fractal Structure
subject: Causality
subject: Emergent Spacetime
subject: Space-time
subject: Metric Generation
subject: Singularity Resolution
subject: Galactic Rotation Curves
subject: Casimir Force Deviation
subject: NANOGrav Observations
subject: Quantum Gravity
subject: Fractal Geometry in Physics

description: While General Relativity (GR) and Quantum Mechanics (QM) have dominated modern physics, the Pure Time Theory (PTT) introduces a new ontological scalar field — Trelax — that governs the emergence of all physical structures, including a region-dependent perception of spacetime itself. This article provides a didactic comparison between PTT and GR, clarifying their philosophical and physical differences, and illustrating how PTT redefines simultaneity, causality, and time dilation.

Through precise definitions, comparative tables, and intuitive analogies, we aim to remove any remaining ambiguity about the position and potential of PTT. Though unobservable directly, its empirical echoes — such as clock desynchronization, Casimir deviations, and cosmological drift — validate its physical reality. It also offers natural resolutions to classical singularities — including black holes and the Big Bang — by replacing geometric collapse with smooth temporal evolution.

Beyond resolving such singularities, PTT extends into quantum regimes, offering a unified interpretation of phase evolution, antimatter, and apparent randomness. It reframes observation itself as the result — not the origin — of structure, and reveals a hidden temporal hierarchy whose fractal geometry governs scale-invariant phenomena across the cosmos.
Intragenus F1-hybrids of African weakly electric fish (Mormyridae: Campylomormyrus tamandua ♂ × C. compressirostris ♀) are fertile
Creators: name: Korniienko, Yevheniia
name: Nguyen, Linh
name: Baumgartner, Stephanie
name: Vater, Marianne
name: Tiedemann, Ralph
name: Kirschbaum, Frank
Publisher: name: Humboldt-Universität zu Berlin
Year: 2020
Subjects: subject: Mormyridae
subject: Campylomormyrus
subject: F1-hybrids
subject: F2-hybrids
subject: Fertility
subject: 610 Medizin und Gesundheit

description: Hybridization is widespread in fish and constitutes an important mechanism in fish speciation. There is, however, little knowledge about hybridization in mormyrids. F1-interspecies hybrids between Campylomormyrus tamandua ♂ × C. compressirostris ♀ were investigated concerning: (1) fertility; (2) survival of F2-fish and (3) new gene combinations in the F2-generation concerning the structure of the electric organ and features of the electric organ discharge. These F1-hybrids achieved sexual maturity at about 12–13.5 cm total length. A breeding group comprising six males and 13 females spawned 28 times naturally proving these F1-fish to be fertile. On average 228 eggs were spawned, the average fertilization rate was 47.8%. Eggs started to hatch 70–72 h after fertilization, average hatching rate was 95.6%. Average mortality rate during embryonic development amounted to 2.3%. Average malformation rate during the free embryonic stage was 27.7%. Exogenous feeding started on day 11. In total, we raised 353 normally developed larvae all of which died consecutively, the oldest specimen reaching an age of 5 months. During survival, the activities of the larval and adult electric organs were recorded and the structure of the adult electric organ was investigated histologically.
Sonata für Violine und Pianoforte : [A-Dur]
Creators: name: Fröhlich, Friedrich Theodor
Publisher: name: [s.n.]
Year: 1803

description: [Friedrich Theodor Fröhlich]
description: Unvollständig
description: Geschenk 1927 *27.932 Öffentliche Bibliothek der Universität Basel
description: Verzeichnung=Description=Inventaire 2009 Übernahme Rekatalogis. AK UB durch Medea 2002-2005
description: Digitalisierung=Digitization=Numérisation Juni 2024 TIFF