cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Samantha Cristoforetti è sulla Stazione spaziale
Creators: Redazione Esa
Publisher: name: Media Inaf
Year: 2022

Il veicolo spaziale Crew Dragon Freedom, che porta l'astronauta dell'Esa Samantha Cristoforetti e i suoi colleghi della Nasa Kjell Lindgren, Robert Hines e Jessica Watkins, ha effettuato l’attracco sulla Stazione spaziale internazionale giovedì 28 aprile all'01:37 ora italiana
Su Marte, missione Delta Front iniziata
Creators: Rossella Spiga
Publisher: name: Media Inaf
Year: 2022

È iniziata con oltre un mese di anticipo la seconda campagna scientifica di Perseverance, la Delta Front. Il rover Nasa ha raggiunto il delta del fiume ormai in secca, dopo la traversata del cratere Jezero, e raccoglierà campioni geologici da inviare sulla Terra. Con un commento di Teresa Fornaro (Inaf), participating scientist della missione
[Letter from Hu Shiguang to Hu Shiding]
[胡世光致胡世定的信]
Creators: name: Hu, Shiguang
Publisher: name: The University of British Columbia
Year: 2011

description: Hu Shiguang tells Hu Shiding that the four contract workers have arrived in Vancouver. The fishing net will be set on May 15, but the cold weather may affect the cannery's production.
Comparative Physicochemical Evaluation of Biofield Treated Phosphate Buffer Saline and Hanks Balanced Salt Medium
Creators: name: Trivedi, Mahendra
Publisher: name: SMN - The ScienceMedia Network
Year: 2016
Subjects: Natural Sciences
Chemistry

description: Phosphate buffer saline (PBS) has numerous biological and pharmaceutical applications. Hank buffer salt (HBS) has been used as a medium for tissue culture applications. This research study was aimed to investigate the influence of Mr. Trivedi’s biofield energy treatment on physicochemical properties of the PBS and HBS. The study was executed in two group’s i.e. control and treated. The control group was kept aside as control and treated group had received the biofield energy treatment. The control and treated samples were further characterized by X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and Fourier transform infrared (FT-IR) spectroscopy. The XRD analysis indicated the increase in crystallite size by 5.20% in treated PBS as compared to the control. Similarly, the treated HBS also showed increase in crystallite size by 3.20% with respect to the control. Additionally, the treated PBS showed an increase in Bragg’s angle (2θ) as compared to the control sample. However, a decrease in Bragg’s angle of XRD peaks of the treated sample was noticed in the treated HBS. The DSC analysis of the control PBS showed melting temperature at 224.84°C; however melting temperature was not observed in the treated sample. However, DSC analysis of the treated HBS showed an increase in melting temperature (152.83°C) in comparison with the control (150.60°C). Additionally, the latent heat of fusion of the treated HBS was increased substantially by 108.83% as compared to the control. The TGA thermogram of the treated PBS showed an increase in onset of thermal degradation (212°C) as compared to the control (199°C). Whereas, the treated HBS showed less weight loss comparing with the control sample. This indicated the increase in thermal stability of the both the treated PBS and HBS samples. The FT-IR spectroscopic analysis of treated PBS showed alterations in the frequency of the functional groups such as O-H, C-H, P=O, O=P-OH, and P-OH as compared to the control. Additionally, the FT-IR spectrum of the treated HBS showed increase in frequency of calcium chloride phase (1444→1448 cm-1) as compared to the control sample. Altogether, it was observed that biofield energy treatment had caused physical, thermal and spectral changes in the treated samples as compared to the control. It is assumed that biofield energy treated PBS and HBS could be a good prospect for biological and tissue culture applications.
Supplementary document for Fourier ptychographic topography - 6327248.pdf
Creators: name: Wang, Hao
name: Zhu, Jiabei
name: Sung, Jangwoon
name: Hu, Guorong
name: Greene, Joseph
name: Li, Yunzhe
name: Park, Seungbeom
name: KIM, WOOKRAE
name: Lee, Myungjun
name: Yang, Yusin
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: supplement
Samantha Cristoforetti è in volo verso la Iss
Creators: Redazione Ansa
Publisher: name: Media Inaf
Year: 2022

Dopo il lancio avvenuto alle 9:52 ora italiana di oggi, mercoledì 27 aprile, dal Launch Complex 39A del Kennedy Space Center della Nasa, in Florida, gli astronauti della Crew-4 sono in orbita verso la Stazione spaziale internazionale. A bordo gli astronauti della Nasa Kjell Lindgren, Robert Hines, Jessica Watkins e l’astronauta dell’Esa Samantha Cristoforetti
title: Rules In Crisis
Creators: name: Adams, Mark
Publisher: name: George Mason University
Year: 2009
Subjects: subject: Public choice
subject: Tiebout
subject: Disaster
subject: Constitution
subject: Law
subject: FOS: Law
subject: Crisis

description: Societies exist where individuals agree to live together and abide by a common set of rules. These rules seek to limit, but to not eliminate, predation. When a community is struck by a disaster the environment changes but rules frequently do not adapt; discouraging investment and repopulation and hindering recovery. The laws governing private contracts have evolved mechanism for avoiding harmful rigidity during times of crisis. This thesis proposes a means of applying a similar mechanism to the binding constraints in social interactions with the aim of increasing the likelihood of the community surviving and rebuilding.
title: Newspaper Column: Reston's Clouded Future Needs Heroes
Creators: name: Nicoson, William J.
Publisher: name: The Connection
Year: 1999
Subjects: subject: Reston (Va.)
subject: Reston (VA) Association (RA)
subject: Assessment
subject: Taxes

description: PDF file distilled from original WordPerfect document. Original size 11" x 8.5".
description: The Reston Association at the close of the millennium will find itself in a thicket of daunting financial challenges threatening its continuing capacity to protect and enhance both the life-style of Restonians and their property values. That’s the unhappy message which will surely be conveyed to RA members at their annual meeting on April 13 (7 p.m. at the Hyatt) and in RA’s annual report. By comparison, the Reston Community Center will have enlarged its commitment to the community by establishing an outpost in Lake Anne, and the financial resources to pursue its growing mission will be assured. That’s fortunate since RCC doesn’t hold annual meetings or issue annual reports.
An ISBD perspective on the sociocultural challenges of managing bipolar disorder: A content analysis
Creators: name: Belmaker, Robert H
name: Oedegaard, Ketil J
name: Berk, Lesley
name: Youngstrom, Eric A
name: Berk, Michael
name: Dilsaver, Steven C
name: Fasmer, Ole B
name: Oedegaard, Christine H
name: Force, International Society for Bipolar Disorders Transcultural Task
name: Engebretsen, Ingunn M
Publisher: name: SAGE Publications
Year: 2016

description: OBJECTIVE: Clinical management of bipolar disorder patients might be affected by culture and is further dependent on the context of healthcare delivery. There is a need to understand how healthcare best can be delivered in various systems and cultures. The objective of this qualitative study was to gain knowledge about culture-specific values, beliefs and practices in the medical care provided to patients with bipolar disorders from a provider perspective in various areas of the world.
SAMPLING AND METHODS: The International Society for Bipolar Disorders (ISBD) network provided the framework for this qualitative study. An electronic interview with open-ended questions was administered to 19 international experts on bipolar spectrum disorder representing the International Society for Bipolar Disorders chapter network in 16 countries and six continents. In addition, there were two in-depth interviews with bipolar spectrum disorder experts done prior to the survey. The data were analysed using content analysis, and the information was structured using the software NVivo by QSR International Pty Ltd.
FINDINGS: All participants described sociocultural factors as important in healthcare delivery to bipolar patients in their part of the world, both in accessing healthcare and in providing culturally appropriate care. Factors that affected the provider's ability to supply good clinical management of patients were access to treatment options and long-term follow-up, as well as general strategies to combat stigma. In some societies, the patients' use of alternative treatments, gender issues and religion were also important factors. Understanding the impact of such culturally specific factors was overall regarded as essential for proper treatment interventions.
CONCLUSION: Sociocultural factors clearly affect the nature and quality of medical services delivered to bipolar patients. Financial, social and cultural factors affect patients' health-seeking behaviour, and this highlights the need for knowledge about such factors in order to adequately identify and treat bipolar patients globally. Culturally adapted training and psychoeducation programmes are particularly warranted.
title: It’s About Russia
Creators: name: Cohen, Dan
Publisher: name: George Mason University
Year: 2007
Subjects: subject: Research
subject: Scholarship
subject: Tools
subject: Text mining
subject: Visualization

description: Originally published by Dan Cohen on Dan Cohen's Digital Humanities Blog (www.dancohen.org). This work is licensed under a Creative Commons Attribution 3.0 United States License (http://creativecommons.org/licenses/by/3.0/us/).
title: Through Line
Creators: name: Hentges, Kerry
Publisher: name: George Mason University
Year: 2023
Subjects: subject: Anxiety
subject: Death
subject: Printmaking
subject: Fear
subject: Tapestry

description: This thesis explores the graduate exhibition, Through Line, from Fall 2021 by Kerry Hentges. The exhibition focuses on anxiety and how to relieve it through art-making. Both prints and fabric tapestries are showcased. The title of the exhibit, Through Line, references both the literal lines used to create the works of art and the figurative line that connects us all as human beings. The exhibit was displayed at George Mason University in November 2021 at the Gillespie Gallery.
CDI/CDS system-encoding genes of Burkholderia thailandensis are located in a mobile genetic element that defines a new class of transposon
Creators: name: Ocasio, Angelica B.
name: Cotter, Peggy A.
Publisher: name: Public Library of Science (PLoS)
Year: 2019

description: Intercellular communication and self-recognition are critical for coordinating cooperative and competitive behaviors during sociomicrobiological community development. Contact-dependent growth inhibition (CDI) proteins are polymorphic toxin delivery systems that inhibit the growth of non-self neighboring bacteria that lack the appropriate immunity protein. In Burkholderia thailandensis, CDI system proteins (encoded by bcpAIOB genes) also induce cooperative behaviors among sibling (self) cells, a phenomenon called contact-dependent signaling (CDS). Here we describe a mobile genetic element (MGE) that carries the bcpAIOB genes in B. thailandensis E264. It is a ~210 kb composite transposon with insertion sequence (IS) elements at each end. Although the ISs are most similar to IS2 of Escherichia coli, the transposase-dependent intermediate molecule displays characteristics more similar to those of the IS26 translocatable unit (TU). A reaction requiring only the "left" IS-encoded transposase results in formation of an extrachromosomal circular dsDNA intermediate ("the megacircle") composed of the left IS and the sequences intervening between the ISs. Insertion of the megacircle into the chromosome occurs next to a pre-existing copy of an IS2-like element, recreating a functional composite transposon. We found that BcpA activity is required for megacircle formation, and in turn, megacircle formation is required for CDS phenotypes. Our data support a model in which the bcpAIOB genes function as both helping and harming greenbeard genes, simultaneously enhancing the fitness of self bacteria that possess the same allele plus tightly linked genes that mediate cooperative behaviors, and killing non-self bacteria that do not possess the same bcpAIOB allele. Mobility of the megacircle between cells could allow bacteria invading a community to be converted to self, and would facilitate propagation of the bcpAIOB genes in the event that the invading strain is capable of overtaking the resident community.
title: Aggression in Preschool and Predictions of Peer Reactions; How Do Children Expect Their Peers to Feel in Response to Their Behaviors?
Creators: name: Mahoney, Amanda J.
Publisher: name: George Mason University
Year: 2010
Subjects: subject: Preschool
subject: Aggression
subject: Emotion knowledge
subject: Predicting emotions
subject: Social expectations

description: Children’s aggression at early ages is indicative of concurrent and future adjustment problems. The aggressive behaviors may be due to, for example, developmental delays, lack of experience in social situations, or the inability to understand social norms. Aggression in preschool is related to concurrent and later peer rejection, which tends to remain stable throughout elementary school, and feed into a cycle of aggressive behaviors and social impairment. Examining the development of aggression in preschool children is valuable to the understanding of how children view their own behaviors and how they believe others will respond to their behaviors. Data was collected from 364 preschool students from Northern Virginia via teacher-report, self-report, and behavioral observations. Results found that observed negative affect and negative reactions to frustration were significant predictors of teacher-rated anger/aggression. However, gender interacted with these variables and boys that were rated higher on anger/aggression showed more negative affect than boys rater lower on anger/aggression. This effect was not seen for females. Positive reactions to frustration was also found to be a small, yet significant predictor of teacher-rated anger/aggression. Teacher-rated anger/aggression was not found to be related to child reported feelings or behaviors in a challenging situation. Children who chose that they would react aggressively in a challenging situation tended to predict that their peer would feel sad in response to their aggression. Following avoidant behaviors, children most likely expected their peer to feel happy. Analyses revealed that girls who chose to cry or manipulate in a stressful situation most frequently predicted their peer to feel happy in response to their crying. Children who chose to respond prosocially tended to expect their peer to feel happy as a result of their behavior. The results of this study show that aggressive children may be able to understand that their aggressive behaviors will have negative social consequences. These aggressive behaviors may not be because of a lack of emotion knowledge, but related more to impulse control.
Drosophila, which lacks canonical transcription-coupled repair proteins, performs transcription-coupled repair
Creators: name: Deger, Nazli
name: Yang, Yanyan
name: Lindsey-Boltz, Laura A
name: Selby, Christopher P
name: Sancar, Aziz
Publisher: name: Elsevier
Year: 2019

description: Previous work with the classic T4 endonuclease V digestion of DNA from irradiated Drosophila cells followed by Southern hybridization led to the conclusion that Drosophila lacks transcription-coupled repair (TCR). This conclusion was reinforced by the Drosophila Genome Project, which revealed that Drosophila lacks Cockayne syndrome WD repeat protein (CSA), CSB, or UV-stimulated scaffold protein A (UVSSA) homologs, whose orthologs are present in eukaryotes ranging from Arabidopsis to humans that carry out TCR. A recently developed in vivo excision assay and the excision repair-sequencing (XR-Seq) method have enabled genome-wide analysis of nucleotide excision repair in various organisms at single-nucleotide resolution and in a strand-specific manner. Using these methods, we have discovered that Drosophila S2 cells carry out robust TCR comparable with that observed in mammalian cells. Our findings provide critical new insights into the mechanisms of TCR among various different species.
All’origine delle dune di Io
Creators: Maura Sandri
Publisher: name: Media Inaf
Year: 2022

Uno studio della Rutgers University presenta una nuova ipotesi su come sia possibile la formazione di dune sulla superficie della luna più interna di Giove, Io. La ricerca si basa su uno studio dei processi fisici che controllano il movimento dei grani, accoppiato con un'analisi delle immagini della sonda spaziale Galileo della Nasa che ha operato dal 1989 al 2003
Quasicristalli, la storia d’una scoperta impossibile
Creators: Claudia Sciarma
Publisher: name: Media Inaf
Year: 2022

Irregolare, proibito e impossibile: è il quasicristallo. Ha una struttura regolare ma non periodica e fino a pochi anni fa sembrava non ci fosse alcuna possibilità di trovarlo in natura. Poi, un viaggio surreale in un luogo remoto, studi in laboratorio e una squadra di scienziati e scienziate infrangono questa certezza. Questa storia è raccontata nel saggio “Quasicristalli” di Luca Bindi, professore di mineralogia e cristallografia dell'Università di Firenze
A population-based family clustering study of tic-related obsessive-compulsive disorder
Creators: name: Rosenqvist, Mina A.
name: Kuja-Halkola, Ralf
name: Brander, Gustaf
name: Larsson, Henrik
name: Rück, Christian
name: Lichtenstein, Paul
name: Fernández de la Cruz, Lorena
name: Mataix-Cols, David
name: Serlachius, Eva
name: Crowley, James J.
Publisher: name: Springer Nature
Year: 2019

description: In the latest edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), obsessive-compulsive disorder (OCD) included a new “tic-related” specifier. However, strong evidence supporting tic-related OCD as a distinct subtype of OCD is lacking. This study investigated whether, at the population level, tic-related OCD has a stronger familial load than non-tic-related OCD. From a cohort of individuals born in Sweden between 1967 and 2007 (n = 4,085,367; 1257 with tic-related OCD and 20,975 with non-tic-related OCD), we identified all twins, full siblings, maternal and paternal half siblings, and cousins. Sex- and birth year-adjusted hazard ratios (aHR) were calculated to estimate the risk of OCD in relatives of individuals with OCD with and without comorbid tics, compared with relatives of unaffected individuals. We found that OCD is a familial disorder, regardless of comorbid tic disorder status. However, the risk of OCD in relatives of individuals with tic-related OCD was considerably greater than the risk of OCD in relatives of individuals with non-tic-related OCD (e.g., risk for full siblings: aHR = 10.63 [95% CI, 7.92–14.27] and aHR = 4.52 [95% CI, 4.06–5.02], respectively; p value for the difference < 0.0001). These differences remained when the groups were matched by age at first OCD diagnosis and after various sensitivity analyses. The observed familial patterns of OCD in relation to tics were not seen in relation to other neuropsychiatric comorbidities. Tic-related OCD is a particularly familial subtype of OCD. The results have important implications for ongoing gene-searching efforts.
Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs
Creators: name: Adebali, Ogun
name: Yimit, Askar
name: Jiang, Yuchao
name: Sancar, Aziz
Publisher: name: Springer Nature
Year: 2019

description: The platinum-based drug cisplatin is a widely used first-line therapy for several cancers. Cisplatin interacts with DNA mainly in the form of Pt-d(GpG) di-adduct, which stalls cell proliferation and activates DNA damage response. Although cisplatin shows a broad spectrum of anticancer activity, its utility is limited due to acquired drug resistance and toxicity to non-targeted tissues. Here, by integrating genome-wide high-throughput Damage-seq, XR-seq, and RNA-seq approaches, along with publicly available epigenomic data, we systematically study the genome-wide profiles of cisplatin damage formation and excision repair in mouse kidney, liver, lung and spleen. We find different DNA damage and repair spectra across mouse organs, which are associated with tissue-specific transcriptomic and epigenomic profiles. The framework and the multi-omics data we present here constitute an unbiased foundation for understanding the mechanisms of cellular response to cisplatin. Our approach should be applicable for studying drug resistance and for tailoring cancer chemotherapy regimens.
C’è anche l’astrofisica alla Safety Week 2022
Creators: Redazione Media Inaf
Publisher: name: Media Inaf
Year: 2022

Debutta a Milano dal 26 al 30 aprile 2022 la settimana dedicata alla cultura della sicurezza. L’Istituto nazionale di astrofisica sarà presente per parlare di inclusione e per presentare insieme a Nvk Design il prototipo di “Saturno”, un dispositivo per la disinfezione e l’inattivazione degli agenti patogeni in ambienti chiusi nato dall’incontro tra tecnologia d’avanguardia e design sostenibile
A systems pharmacokinetic/pharmacodynamic model for concizumab to explore the potential of anti-TFPI recycling antibodies
Creators: name: Yuan, Dongfen
name: Cao, Yanguang
name: Rode, Frederik
Publisher: name: Elsevier
Year: 2019

description: Concizumab is a humanized monoclonal antibody in clinical investigation directed against membrane-bound and soluble tissue factor pathway inhibitor (mTFPI and sTFPI) for treatment of hemophilia. Concizumab displays a non-linear pharmacokinetic (PK) profile due to mTFPI-mediated endocytosis and necessitates a high dose and frequent dosing to suppress the abundant sTFPI, a negative regulator of coagulation. Recycling antibodies that can dissociate bound mTFPI/sTFPI in endosomes for degradation and rescue antibody from degradation have a potential in reducing the dose by extending antibody systemic persistence and sTFPI suppression. We developed a systems PK/pharmacodynamics (PD) model with nested endosome compartments to simulate the effect of decreased antibody binding to mTFPI/sTFPI in endosomes on antibody clearance and sTFPI suppression for exploring the potential of anti-TFPI recycling antibodies in reducing the dose. A dynamic model-building strategy was taken. A reduced PK/PD model without the endosome compartments was developed to optimize unknown target turnover parameters using concizumab PK data. The optimized parameters were then employed in the systems PK/PD model for simulations. The obtained systems PK/PD model adequately described the PK of concizumab in rabbits, monkeys, and humans and the PD in humans. The systems PK/PD model predicted that an anti-TFPI recycling antibody with a 100-fold higher mTFPI/sTFPI dissociation constant in endosomes than concizumab can extend sTFPI suppression from 12 days to 1 month. Thus, the systems PK/PD model provides a quantitative platform for guiding the engineering and translational development of anti-TFPI recycling antibodies.
Apoptotic cell death regulation in neurons
Creators: name: Hollville, Emilie
name: Romero, Selena E.
name: Deshmukh, Mohanish
Publisher: name: Wiley
Year: 2019

description: Apoptosis plays a major role in shaping the developing nervous system during embryogenesis as neuronal precursors differentiate to become post-mitotic neurons. However, once neurons are incorporated into functional circuits and become mature, they greatly restrict their capacity to die via apoptosis, thus allowing the mature nervous system to persist in a healthy and functional state throughout life. This robust restriction of the apoptotic pathway during neuronal differentiation and maturation is defined by multiple unique mechanisms that function to more precisely control and restrict the intrinsic apoptotic pathway. However, while these mechanisms are necessary for neuronal survival, mature neurons are still capable of activating the apoptotic pathway in certain pathological contexts. In this review, we highlight key mechanisms governing the survival of post-mitotic neurons, while also detailing the physiological and pathological contexts in which neurons are capable of overcoming this high apoptotic threshold.
title: Die Darstellung von Entwicklungspolitik in hessischen Schulbüchern
Creators: name: Jakob, Kilian Paul Hendrik
Publisher: name: KOBRA Universität Kassel
Year: 2024
Subjects: subject: Schulbücher
subject: Sekundarstufe II
subject: Entwicklungspolitik
subject: Kritische Diskursanalyse
subject: Macht-Wissen-Strukturen
subject: Entwicklung
subject: Entwicklungsdiskurs
subject: Eurozentrisch
subject: Homogenisierend
subject: Schülerinnen und Schüler
classificationCode: 370
subject: 370
classificationCode: Hessen
subject: Hessen
classificationCode: Schulbuch
subject: Schulbuch
classificationCode: Sekundarstufe 2
subject: Sekundarstufe 2
classificationCode: Entwicklungspolitik
subject: Entwicklungspolitik
classificationCode: Entwicklung
subject: Entwicklung
classificationCode: Kritische Diskursanalyse
subject: Kritische Diskursanalyse
classificationCode: Eurozentrismus
subject: Eurozentrismus
classificationCode: Homogenität
subject: Homogenität

description:
Die Arbeit analysiert die Darstellung von Entwicklungspolitik in Schulbüchern der Sekundarstufe II in Hessen mit einem Fokus auf das Fach Politik und Wirtschaft. Mit der Kritischen Diskursanalyse nach Jäger wird untersucht, wie sprachliche Darstellungen den Entwicklungsdiskurs inhaltlich prägen und welche Macht-Wissen-Strukturen dadurch reproduziert werden. Die Untersuchung basiert auf drei ausgewählten Schulbüchern und umfasst eine detaillierte Analyse der Begriffe „Entwicklungsdiskurs“, „Entwicklung“ und „Entwicklungspolitik“ aus postkolonialer Perspektive.
Ergebnisse zeigen, dass die Schulbücher den Entwicklungsdiskurs häufig eurozentristisch und homogenisierend gestalten, wobei alternative Perspektiven des Globalen Südens unterrepräsentiert sind. Diese normativen Darstellungen beeinflussen, wie Schüler*innen Entwicklung und globale Machtverhältnisse wahrnehmen. Abschließend wird eine kritische Reflexion der Potenziale für eine inklusivere und differenziertere Darstellung in Lehrmaterialien angeboten, um hegemoniale Diskurse zu hinterfragen und vielfältigere Narrative zu fördern.
Misurare la taglia delle galassie con le reti neurali
Creators: Ufficio stampa Inaf
Publisher: name: Media Inaf
Year: 2022

È la prima volta che questa tecnica viene applicata su dati raccolti da Terra, dimostrando che le reti neurali sono molto più veloci e accurate rispetto a tecniche tradizionali e rappresentano il futuro per misurare oggetti astronomici nelle campagne osservative su grandi porzioni di cielo. L'articolo è stato pubblicato su The Astrophysical Journal
È l’ora della geoetica, per una scienza responsabile
Creators: Valentina Guglielmo
Publisher: name: Media Inaf
Year: 2022

In occasione della Giornata della Terra abbiamo intervistato Silvia Peppoloni, direttrice del “Journal of Geoethics and Social Geosciences”, la nuova rivista scientifica dell’Ingv dedicata alla geoetica: una scienza che mette insieme le geoscienze a tutte le discipline che riguardano l’interazione dell’uomo con il territorio
title: Challenges to the Systematic Adoption of Person-Centered Planning
Creators: name: Wolf-Branigin, Michael
name: LeRoy, Barbara
name: Wolf-Branigin, Karen
name: Israel, Nathaniel
name: Kulik, Noel
Publisher: name: George Mason University
Year: 2007
Subjects: subject: Person-centered
subject: Consumer-directed
subject: Complexity
subject: Feedback
subject: Personal futures

description: Copyright 2007 Lyceum Books, Inc.
description: Previous reviews of person-centered planning indicate a need for more comprehensive training to promote skill generalization. A three-phase training intervention was implemented with 22 planning teams for people with a disability in the Detroit metropolitan area. Independent observers rated team meetings posttraining on consumer orientation regarding three components of person-centered planning: meeting structure, interpersonal skills, and planning strategies. Analyses of ratings indicated that structural skills were significantly more readily incorporated than either interpersonal or strategic skills. Exploratory analyses indicated that the number of family members, friends, and advocates at the planning meetings was positively correlated with planning strategies, while living arrangements were negatively correlated with planning strategies. Implications for the acquisition and generalization of more complex planning skills are discussed.
Quando scatta la scintilla fra stella e pianeta
Creators: Mario Guarcello
Publisher: name: Media Inaf
Year: 2022

Un team guidato dall’astrofisico Ignazio Pillitteri dell’Inaf di Palermo ha analizzato le osservazioni compiute con Xmm-Newton per studiare la relazione tra l’attività coronale della stella HD 189733 A e l’orbita del suo pianeta. Dai risultati, pubblicati su A&A, emerge che l’energia rilasciata durante i brillamenti sembra subire gli effetti dell’interazione magnetica tra stella e pianeta
Compie 15 anni il satellite “made in Italy” Agile
Creators: Ufficio stampa Inaf
Publisher: name: Media Inaf
Year: 2022

Nato per restare in orbita per due anni, il telescopio spaziale per le alte energie Agile – ideato, progettato e costruito in Italia – ha superato tutte le più rosee aspettative di vita. La sua scienza ci sta regalando importanti contributi
Defective fatty acid oxidation in mice with muscle-specific acyl-CoA synthetase 1 deficiency increases amino acid use and impairs muscle function
Creators: name: Li, Lei O
name: Martin, Sarah A
name: Coleman, Rosalind A
name: Klett, Eric L
name: Suchanek, Amanda L
name: Young, Pamela A
name: Bacudio, Lawrence
name: Shulman, Gerald I
name: Perry, Rachel J
name: Pascual, Florencia
name: Camporez, Joao-Paulo
name: Zhao, Liyang
Publisher: name: Elsevier
Year: 2019

description: Loss of long-chain acyl-CoA synthetase isoform-1 (ACSL1) in mouse skeletal muscle (Acsl1M-/-) severely reduces acyl-CoA synthetase activity and fatty acid oxidation. However, the effects of decreased fatty acid oxidation on skeletal muscle function, histology, use of alternative fuels, and mitochondrial function and morphology are unclear. We observed that Acsl1M-/- mice have impaired voluntary running capacity and muscle grip strength and that their gastrocnemius muscle contains myocytes with central nuclei, indicating muscle regeneration. We also found that plasma creatine kinase and aspartate aminotransferase levels in Acsl1M-/- mice are 3.4- and 1.5-fold greater, respectively, than in control mice (Acsl1flox/flox), indicating muscle damage, even without exercise, in the Acsl1M-/- mice. Moreover, caspase-3 protein expression exclusively in Acsl1M-/- skeletal muscle and the presence of cleaved caspase-3 suggested myocyte apoptosis. Mitochondria in Acsl1M-/- skeletal muscle were swollen with abnormal cristae, and mitochondrial biogenesis was increased. Glucose uptake did not increase in Acsl1M-/- skeletal muscle, and pyruvate oxidation was similar in gastrocnemius homogenates from Acsl1M-/- and control mice. The rate of protein synthesis in Acsl1M-/- glycolytic muscle was 2.1-fold greater 30 min after exercise than in the controls, suggesting resynthesis of proteins catabolized for fuel during the exercise. At this time, mTOR complex 1 was activated, and autophagy was blocked. These results suggest that fatty acid oxidation is critical for normal skeletal muscle homeostasis during both rest and exercise. We conclude that ACSL1 deficiency produces an overall defect in muscle fuel metabolism that increases protein catabolism, resulting in exercise intolerance, muscle weakness, and myocyte apoptosis.
title: Amaya's Garden
Creators: name: Mitchell, Carol
Publisher: name: George Mason University
Year: 2021

description: This thesis has been embargoed for 10 years. It will not be available until May 2030 at the earliest.
description: This thesis is a novel about a young woman growing up in Jamaica who loses her immediate family. Using a non-linear approach to the story-telling, the book shows how the events shape her life and how she picks up the pieces. The book is about trauma and survival. In 1979, Amaya is seventeen years old. The political situation in Jamaica is unsavory; party politics rule and the divisiveness is characterized by a significant level of violence. Amaya’s father’s business is directly impacted by the political situation. Her father is threatened at work and Amaya’s mother, after years of trying and miscarriages, is at the start of her third trimester of a pregnancy, and Amaya’s sister, Amaryllis, has fallen for Dave, a young man of whom both Amaya and her father disapprove. All these tensions come to a head one night and ends in a terrible disaster. Amaya pulls her life back together. She finishes high school, and goes to University in Kingston Jamaica, leaving behind most people who know her tragic past. She becomes pregnant and grabs at an opportunity to flee her past entirely by moving to the United States with the father. There, after a difficult start, she lives a comfortable life with her husband. He is a lawyer and she manages his practice and raises their son. She completely buries memories of her troubled past, of which her husband is not aware. When the memories begin to intrude on her present, Amaya’s life unravels once more and she is forced to face and deal with her past. *** At the heart of the book as I have conceived it is the idea of trauma, survival, and whether it is possible to escape the way our past has shaped us. In the Caribbean, trauma is seldom addressed. People are advised to just move on and get over it. We are praised as being resilient when we face natural disasters with stoicism, and people are often ridiculed for seeking professional help to overcome difficult experiences. This attitude is slowly changing however, I do want to highlight the impact of not dealing with trauma, the way it manifests itself in unpleasant forms and the ways in which it can be passed on through our DNA.
Buchi neri intermedi e dove trovarli
Creators: Maura Sandri
Publisher: name: Media Inaf
Year: 2022

Un nuovo studio pubblicato su The Astrophysical Journal fornisce la prima prova osservativa a sostegno della teoria secondo cui i buchi neri intermedi possono formarsi negli ammassi nucleari stellari. Per arrivare a questo risultato, i ricercatori hanno utilizzato il Chandra X-Ray Observatory per cercare le firme nei raggi X dei buchi neri negli ammassi nucleari stellari in 108 diverse galassie
Διερεύνηση παραγόντων ανάπτυξης της οικοτεχνικής επιχειρηματικότητας: Μελέτη περίπτωσης στην Περιφερειακή Ενότητα Έβρου
Creators: name: Φάνη, Ελισάβετ
Publisher: name: Aristotle University of Thessaloniki
Year: 2025
Subjects: Γεωπονία
Οικοτεχνία
Έβρος
Agriculture
Cottage industry
Evros

description: Η παρούσα μεταπτυχιακή διπλωματική εργασία εστιάζει στην προστιθέμενη αξία που μπορεί να προσφέρει η ανάπτυξη της οικοτεχνίας στην επιχειρηματικότητα της υπαίθρου, με έμφαση στην αγροτική περιοχή της Περιφερειακής Ενότητας Έβρου. Κεντρικός στόχος είναι να διερευνήσει τις στάσεις και απόψεις των επιχειρηματιών (και στελεχών συνεταιριστικών μονάδων) της Περιφερειακής Ενότητας Έβρου σχετικά με την ανάπτυξη της οικοτεχνίας και την επιχειρηματικότητα στην περιοχή μελέτης. Συνολικά, η έρευνα επιδιώκει να αναδείξει την κρίσιμη σημασία της οικοτεχνίας για την ενίσχυση της επιχειρηματικότητάς στις αγροτικές περιοχές. Αξιολογεί τις υφιστάμενες συνθήκες και τα εμπόδια που αντιμετωπίζουν οι επιχειρήσεις της περιοχής, προτείνοντας λύσεις που θα μπορούσαν να τις ενισχύσουν. Στόχος είναι να συμβάλει στην ανάπτυξη μιας πιο ανταγωνιστικής και βιώσιμης τοπικής επιχειρηματικότητας, προσαρμόζοντας τις δυνατότητες της οικοτεχνίας στις ιδιαίτερες ανάγκες και προκλήσεις της υπαίθρου.
description: This project focuses on the added value that cottage industry can bring to rural entrepreneurship, with a particular emphasis on the agricultural sector in the Evros regional unit. The central objective is to investigate the attitudes and perspectives of entrepreneurs (and cooperative unit executives) in the Evros Regional Unit regarding the development of cottage industry and entrepreneurship in the study area. Overall, the research aims to highlight the critical importance of the cottage industry in fostering entrepreneurship in rural areas. It evaluates the existing conditions and obstacles faced by the cottage industry in the area, proposing solutions that could strengthen them. The goal is to contribute to the development of a more competitive and sustainable local entrepreneurial ecosystem, adapting the potential of cottage industry to the specific needs and challenges of the rural areas.
Attribute Dynamics and Information Effects on the Acceptability of Gene Edited Orange Juice
Creators: name: Ali, Anam
Publisher: name: Purdue University Graduate School
Year: 2024
Subjects: classificationCode: 380101
subject: Agricultural economics

description: Citrus greening has severely impacted orange trees in America, causing significant damage to farmers and industry. Gene editing has been proposed as a potential solution, but understanding consumer acceptance of the resulting gene edited products is essential to evaluate the marketability of this potential solution.We conducted a hypothetical discrete choice experiment to analyze consumer preferences for gene edited orange juice. We further explored how consumer willingness-to-pay (WTP) for the gene edited attribute varies depending on the total number of attributes presented in the experiment and how information about the benefits of the technology influences WTP across the different attribute scenarios.We find that, on average, consumers devalue the gene edited attribute, but their WTP for the attribute increases when information is provided. Importantly, we also observe that the number of attributes significantly impacts the WTP estimates, but the effect is moderated when information is provided.
Dal 22 aprile riapre il Planetario di Roma
Creators: Redazione Media Inaf
Publisher: name: Media Inaf
Year: 2022

Oggi si è tenuta la cerimonia ufficiale, alla presenza del sindaco di Roma Capitale, Roberto Gualtieri, e dell’assessore capitolino alla Cultura, Miguel Gotor. La nuova struttura si avvale di una tecnologia all’avanguardia e nuovi spettacoli astronomici per condurre il pubblico in un viaggio immersivo alla scoperta della bellezza dell’universo e della sua evoluzione, fino ai più recenti traguardi dell’astrofisica
Evaluation of synergy between host and pathogen-directed therapies against intracellular Leishmania donovani
Creators: name: Johnson, Monica M.
name: Zahid, M. Shamim Hasan
name: Ainslie, Kristy M.
name: Fuchs, James R.
name: Satoskar, Abhay R.
name: Tokarski, Robert J.
name: Bachelder, Eric M.
Publisher: name: Elsevier
Year: 2019

description: Visceral leishmaniasis (VL) is associated with treatment complications due to the continued growth of resistant parasites toward currently available pathogen-directed therapeutics. To limit the emergence and combat resistant parasites there is a need to develop new anti-leishmanial drugs and alternative treatment approaches, such as host-directed therapeutics (HDTs). Discovery of new anti-leishmanial drugs including HDTs requires suitable in vitro assay systems. Herein, we modified and evaluated a series of resazurin assays against different life-stages of the VL causing parasite, Leishmania donovani to identify novel HDTs. We further analyzed the synergy of combinatorial interactions between traditionally used pathogen-directed drugs and HDTs for clearance of intracellular L. donovani. The inhibitory concentration at 50% (IC50) of the five evaluated therapies [amphotericin B (AMB), miltefosine, paromomycin, DNER-4, and AR-12 (OSU-03012)] was determined against promastigotes, extracellular amastigotes, and intracellular amastigotes of L. donovani via a resazurin-based assay and compared to image-based microscopy. Using the resazurin-based assay, all evaluated therapies showed reproducible anti-leishmanial activity against the parasite's different life-stages. These results were consistent to the traditional image-based technique. The gold standard of therapy, AMB, showed the highest potency against intracellular L. donovani, and was further evaluated for combinatorial effects with the HDTs. Among the combinations analyzed, pathogen-directed AMB and host-directed AR-12 showed a synergistic reduction of intracellular L. donovani compared to individual treatments. The modified resazurin assay used in this study demonstrated a useful technique to measure new anti-leishmanial drugs against both intracellular and extracellular parasites. The synergistic interactions between pathogen-directed AMB and host-directed AR-12 showed a great promise to combat VL, with the potential to reduce the emergence of drug-resistant strains.
Project-Based Learning and Problem-Based Learning for EFL Students' Writing Achievement at the Tertiary Level
Creators: name: Affandi, Ahmad
name: Sukyadi, Didi
Publisher: name: RANGSIT  UNIVERSITY  Thailand.
Year: 2016
Subjects: project-based learning (PjBL), problem-based learning (PBL), EFL tertiary level, writing achievement

description: Rangsit  Journal of  Educational Studies, 3, 1
SIYDIK YO'LLARI INFEKSIYALARI BILAN KECHADIGAN HOMILADORLIK XUSUSIYATLARI
Creators: name: Yo'ldosheva, Bibi Anbarra'no
Publisher: name: Zenodo
Year: 2025

description: Bugungi kunda siydik yo’llari infeksiyalari ona va bola salomatligiga hamda tug’ruq jarayoniga jiddiy ta’sir ko’rsatmoqda. Jahon sog’liqni saqlash tashkiloti ham siydik yo’llari infeksiyalarini oldini olish, davolash, hamda maslaxatlar ishlab chiqqan. Surxondaryo viloyatida ham siydik yo’llari infeksiyalari bilan kasallangan homiladorlar kuzatilmoqda. Asimptomatik bakteriouriya simptomlarsiz kuzatilishi natijasida siydik yo’llarida jiddiy asoratlar keltirib chiqarmoqda.
Accuracy of Tonopen Versus iCare in Human Cadaveric Eyes With Edematous Corneas Over a Wide Range of Intraocular Pressures
Creators: name: Grewal, Dilraj S.
name: Olayanju, Jessica
name: Fleischman, David
name: Borras, Terete
name: Ruland, Kelly
Publisher: name: Wolters Kluwer
Year: 2019

description: PURPOSE: The purpose of this study was to compare the accuracy of 2 portable tonometers, Tonopen and iCare, in extreme corneal edema, while also accounting for the location of pressure measurement over a wide range of intraocular pressure (IOP).
METHODS: Utilizing an experimental laboratory investigation, IOP measurements were obtained with iCare and Tonopen against an internal digital manometer in 2 enucleated human cadaveric eyes with edematous corneas. Pachymetry was used to measure central corneal thickness in each eye. Each eye was then mounted on an upright-positioned mannequin, and a 30-G needle connected to a digital manometer was introduced into the anterior chamber at the limbus. Pressures were maintained at 0, 10, 20, 30, 40, and 50 mmHg using the digital manometer. Three measurements were taken with the tonometers at the central cornea, limbal cornea, and sclera, for a total of 9 measurements per device per eye at each manometric pressure reading.
RESULTS: Comparing the mean absolute error of Tonopen versus iCare measurements at the central cornea for each manometric pressure reading, both devices underestimated the control at pressures >10 mmHg, with mean error increasing as IOP increased [mean absolute error (MAE) ranged from 1.67 to 13.33 with Tonopen and 3.67 to 21.00 with iCare]. Tonopen more accurately estimated pressure with an average MAE of 5.72 at the central cornea, compared with MAE of 10.83 at the central cornea for iCare (P<0.03). Comparing MAE between the devices at the limbus, there was no significant difference between the 2 (P=0.91), with average MAE for the Tonopen 5.47 and average MAE for the iCare 5.22. There was no significant difference between average MAE for Tonopen measurements at the central cornea versus the limbus (P=0.89), while the iCare was more accurate at the limbus with average MAE of 5.22 than the central cornea with average MAE of 10.83 (P<0.03). When measuring at the sclera, there was no statistically significant difference between average MAE for Tonopen (18.03) versus iCare (10.39) (P=0.24).
DISCUSSION: Tonopen was more accurate than iCare when measuring at the central cornea, but consistently underestimated the control. MAE for both devices increased linearly with increasing true IOP. With limbus measurements in an edematous cornea, Tonopen and iCare performed similarly. The iCare performed better at the limbus than at the central cornea. Scleral measurements for both Tonopen and iCare were poor. In this experimental model, Tonopen performed superiorly to iCare with central cornea measurements in a grossly edematous cornea. Both devices underestimated true IOP.
title: The United States and the Colombian Conflict: The Construction of a Militarized Intervention; What do Counterinsurgency and Peace Really Mean to the State?
Creators: name: Dyer, Chelsey
Publisher: name: George Mason University
Year: 2014
Subjects: subject: Colombia
subject: Counterinsurgency

description: This thesis assesses the economic and social ramifications of militarized U.S. intervention in Colombia. Using declassified policy and military documents, published accounts, and data collected during an August 2013 fieldwork experience in the Valle de Cauca and Cauca departments in Southwestern Colombia, the author examines how United States and Colombian conceptions of statehood are illuminated through militarized security and economic policies related to, or justified by, the Colombian conflict.
title: Letter: Mary Dublin Keyserling to Jane G. Wilhelm, October 26, 1967.
Creators: name: Keyserling, Mary Dublin
Publisher: name: George Mason University
Year: 2006

description: Letter: Original with signature in blue ink; 11" x 8.5" (27.9cm x 21.6cm)
description: Letter from Mary Dublin Keyserling, Director, Women's Bureau, U.S. Department of Labor, to Jane G. Wilhelm, Executive Director, Reston Virginia Foundation for Community Programs, Inc., October 26, 1967. Keyserling is replying to Wilhelm's request regarding the revised grant application for a demonstration project titled Familiar Problems of Mothers in a New Town; Keyserling stresses the importance of providing child care to women who live in close proximity to employment opportunities. Keyserling praises the proposed program study at Reston to be comprehensive and well-thought out and is most impressed with the program's providing a variety of arrangements depending on the age group of the youngster to be served. Keyserling critiques the application and offers suggestions but mostly praises the proposal. Planned Communitiy Archives Collection, 445.02.
Slitta a non prima del 26 aprile il lancio della Crew-4
Creators: Redazione Ansa
Publisher: name: Media Inaf
Year: 2022

Lancio rimandato di almeno tre giorni – a non prima delle 10:15 (ora italiana) di martedì prossimo – per Samantha Cristoforetti e gli altri tre astronauti della missione Crew-4. La causa è il maltempo, che sta impedendo il rientro in sicurezza della capsula Crew Dragon Endeavour con i quattro astronauti della missione privata Axiom-1 attualmente a bordo della Stazione spaziale