cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Microtus (Alexandromys) kikuchii Kuroda 1920
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Microtus
Microtus kikuchii

description: Microtus (Alexandromys) kikuchii Kuroda 1920
Microtus (Alexandromys) kikuchii Kuroda 1920, Dobuts. Zasshi, 32: 40-41.
Type Locality: Taiwan, Mt Morrison, 10,000 ft (3048 m).
Vernacular Names: Taiwan Vole.
Distribution: Highlands of Taiwan, usually above 3000 m (Lin et al., 1987; H.- T. Yu, 1993; M.-J. Yu, 1996).
Conservation: IUCN – Vulnerable as Volemys kikuckii.
Discussion: Subgenus Alexandromys. Zagorodnyuk (1990) listed this species as the only member of the kikuchii species group, genus Volemys, an arrangement followed by Musser and Carleton (1993); treated as a species of Microtus by Corbet and Hill (1992), or listed in Microtus, subgenus Volemys, by Pavlinov et al. (1995 a). Contrast in cranial conformation between M. kikuchii and Volemys musseri, as well as their striking coronal dissimilarities, earlier emphasized by Lawrence (1982); Corbet and Hill (1992) speculated that M. kikuchii is closely allied to M. fortis, a kinship certainly indicated by molar patterns. Phylogenetic analysis of cytochrome b sequences arranged M. kikuchii as sister species of M. oeconomus, in a clade that includes M. fortis, M. middendorffii, and M. montebelli (Conroy and Cook, 2000 a); furthermore, the standard karyotype of M. kikuchii (2n = 30, FN = 52) is similar to those of M. montebelli and M. oeconomus (Harada et al., 1991). Alliance with M. oeconomus and its kin is zoogeographically sensible since it and M. fortis apparently had a wider geographic distribution during the Pleistocene (including the Ryukyu Isls). Information about the holotype of M. kikuchii and type locality amplified by Jones (1975). Cranial and dental morphometry reported by Kaneko (1987). Ecology, altitudinal distribution, and genetic substructure among populations exhaustively covered by H.- T. Yu (1993, 1994, 1995).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1001, DOI: 10.5281/zenodo.7316535
title: Activité du port de Saint-Malo – 1708 – Port-Louis
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: produits de la mer
subject: épices et condiments

description: Cette fiche est issue de l’enquête menée par Jean Delumeau sur l’activité du port de Saint-Malo au 17e et 18e siècle. Cette fiche correspond à l’activité de l’année 1708 avec le port "Port-Louis"
description: Marchandises arrivées à Saint-Malo : sel
description: Catégories de marchandises arrivées à Saint-Malo : produits de la mer ; épices et condiments
description: Coverage: Petit cabotage
description: Bibliographic citation: LEPROHON, Roger. La Vie maritime à Saint-Malo en 1708. DES : Histoire : Rennes, 1962 (Bibliothèque François-Lebrun, MH 1015)
description: date: Date de numérisation : 2021 à 2023
description: created: Années 1950-1960
Aged Tendon Stem/Progenitor Cells Are Less Competent to Form 3D Tendon Organoids Due to Cell Autonomous and Matrix Production Deficits
Creators: name: Yan, Zexing
name: Yin, Heyong
name: Brochhausen, Christoph
name: Pfeifer, Christian G.
name: Alt, Volker
name: Docheva, Denitsa
Publisher: name: Universität Regensburg
Year: 2020
Subjects: subject: STEM-CELLS; TGF-BETA; MECHANICAL-PROPERTIES; PATELLAR TENDON; SENESCENT CELLS; DIFFERENTIATION; DEGENERATION; GROWTH; SPARC; FATE; tendon age-related degeneration; tendon stem; progenitor cells; tenogenesis; 3D cell sheet model; tendon regeneration
subject: 610 Medizin

description: Tendons are dense connective tissues, which are critical for the integrity and function of our musculoskeletal system. During tendon aging and degeneration, tendon stem/progenitor cells (TSPCs) experience profound phenotypic changes with declined cellular functions that can be linked to the known increase in complications during tendon healing process in elderly patients. Tissue engineering is a promising approach for achieving a complete recovery of injured tendons. However, use of autologous cells from aged individuals would require restoring the cellular fitness prior to implantation. In this study, we applied an established cell sheet model for in vitro tenogenesis and compared the sheet formation of TSPC derived from young/healthy (Y-TSPCs) versus aged/degenerative (A-TSPCs) human Achilles tendon biopsies with the purpose to unravel differences in their potential to form self-assembled three-dimensional (3D) tendon organoids. Using our three-step protocol, 4 donors of Y-TSPCs and 9 donors of A-TSPCs were subjected to cell sheet formation and maturation in a period of 5 weeks. The sheets were then cross evaluated by weight and diameter measurements; quantification of cell density, proliferation, senescence and apoptosis; histomorphometry; gene expression of 48 target genes; and collagen type I protein production. The results revealed very obvious and significant phenotype in A-TSPC sheets characterized by being fragile and thin with poor tissue morphology, and significantly lower cell density and proliferation, but significantly higher levels of the senescence-related gene markers and apoptotic cells. Quantitative gene expression analyses at the mRNA and protein levels, also demonstrated abnormal molecular circuits in the A-TSPC sheets. Taken together, we report for the first time that A-TSPCs exhibit profound deficits in forming 3D tendon tissue organoids, thus making the cell sheet model suitable to investigate the molecular mechanisms involved in tendon aging and degeneration, as well as examining novel pharmacologic strategies for rejuvenation of aged cells.
Discorsobopyrus stebbingi : Boyko 2004
Creators: name: An, Jianmei
name: Boyko, Christopher B.
name: Li, Xinzheng
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Isopoda
Bopyridae
Discorsobopyrus
Discorsobopyrus stebbingi

description: Discorsobopyrus stebbingi (Nierstrasz and Brender à Brandis, 1923)
Bopyrus stebbingi Nierstrasz and Brender à Brandis, 1923: 97–98, pl. 7, fig. 23a–c [Indonesia, infesting unknown host]; Chopra, 1923: 518, 541–542; Bourdon, 1968: 372.
Discorsobopyrus stebbingi: Boyko, 2004: 694– 697, figs. 11–13 [Taiwan, Indonesia, infesting Heterocarpus sibogae de Man, 1917]; Markham, 2010: 159.
? “unidentified bopyrid ” Li and Chan, 2014: 135 [Philippines, infesting H. sibogae].
MATERIAL EXAMINED: None.
HOSTS AND LOCALITIES: Infesting Heterocarpus sibogae de Man, 1917 (Pandalidae), Phil‐ ippines, Indonesia, and Taiwan.
REMARKS: The unidentified bopyrid on a specimen of H. sibogae collected from the
Philippines and cited by Li and Chan (2014) may belong to this species or possibly to Pseudione magna Shiino, 1951 (see Markham, 2010); no other bopyrid is known from this host species.
description: Published as part of An, Jianmei, Boyko, Christopher B. & Li, Xinzheng, 2015, A Review Of Bopyrids (Crustacea: Isopoda: Bopyridae) Parasitic On Caridean Shrimps (Crustacea: Decapoda: Caridea) From China, pp. 1-85 in Bulletin of the American Museum of Natural History 2015 (399) on pages 46-47, DOI: 10.1206/amnb-921-00-01.1, http://zenodo.org/record/4612506
Scoliopteryx libatrix
Creators: name: Fetnassi, Nidal
name: Er-rguibi, Omar
name: Aglagane, Abdessamad
name: Ghamizi, Mohamed
name: Õunap, Erki
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Erebidae
Scoliopteryx
Scoliopteryx libatrix

description: Scoliopteryx libatrix (Linnaeus, 1758)
Notes
One male specimen was found in Taddart in the central High Atlas (Fig. 5 a). According to Rungs (1981) and references therein, the species was not very abundant in Morocco. Rungs (1981) mentioned records from the Rif region, the Atlantic plains and low mountains (northeast and west) and the Middle Atlas, but no records from the High Atlas Mountains.
description: Published as part of Fetnassi, Nidal, Er-rguibi, Omar, Aglagane, Abdessamad, Ghamizi, Mohamed & Õunap, Erki, 2025, Updates to the checklist of nocturnal Macroheterocera (Lepidoptera) of the Central High Atlas of Morocco: One new species added for Morocco, pp. e 137839 in Biodiversity Data Journal 13 on page e137839, DOI: 10.3897/BDJ.13.e137839
Erhebungsmethodik und Datensatzbeschreibung einer Panelbefragung von Umziehenden im Projekt Stawal
Creators: name: Schimohr, Katja
name: Huber, Oliver
name: Scheiner, Joachim
Publisher: name: TU Dortmund
Year: 2024
Subjects: subject: Panelerhebung
subject: Umzug
subject: Mobilität
subject: Wohnen
subject: Wohnstandortwahl
subject: Raumstruktur
subject: Stadtentwicklung
subject: Erhebungsmethodik
subject: 710

description: Arbeitspapiere des Fachgebiets Stadtentwicklung ; 6
Litobopyrus Markham 1982
Creators: name: An, Jianmei
name: Boyko, Christopher B.
name: Li, Xinzheng
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Isopoda
Bopyridae
Litobopyrus

description: Litobopyrus Markham, 1982
DIAGNOSIS (after Markham, 1982): Female: Body distorted; head distinct from pereon; frontal lamina obscure; maxilliped with tuft of setae, palp lacking; barbula of two moderately long projections on each side; oostegite 1 lacking internal ornamentation and posterolateral point; lateral plates elongate; five pairs of biramous pleopods with endopodites reduced to sessile knobs; uropods broad and long.
Male: Greater than three times as long as broad; head medially fused with first pereomere; pereopods subequal, with all articles distinct; pleomeres fused, lacking appendages.
TYPE SPECIES: Litobopyrus longicaudatus Markham, 1982, by original designation.
OTHER SPECIES: None.
description: Published as part of An, Jianmei, Boyko, Christopher B. & Li, Xinzheng, 2015, A Review Of Bopyrids (Crustacea: Isopoda: Bopyridae) Parasitic On Caridean Shrimps (Crustacea: Decapoda: Caridea) From China, pp. 1-85 in Bulletin of the American Museum of Natural History 2015 (399) on page 47, DOI: 10.1206/amnb-921-00-01.1, http://zenodo.org/record/4612506
Leptotyphlops reticulatus
Creators: name: Published, First
Publisher: name: Zenodo
Year: 2007
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Leptotyphlopidae
Leptotyphlops
Leptotyphlops reticulatus

description: The Leptotyphlops reticulatus species group
This group is characterised by the presence of a discrete frontal shield, a rounded snout in lateral view, 10 midtail scale rows, a moderate anterior supralabial, a stout apical spine on the tail (Wallach, 1996), a moderate posterior supralabial and a crescentic cloacal shield. The robust skull has fused parietal bones in Leptotyphlops reticulatus and L. boulengeri. This group was initially known as the L. boulengeri species group (Wallach, 1996).
description: Published as part of Published, First, 2007, A revision of the genus Leptotyphlops in northeastern Africa and southwestern Arabia (Serpentes: Leptotyphlopidae), pp. 1-78 in Zootaxa 1408 on page 17, DOI: 10.5281/zenodo.6789060
Effects of histamine on human periodontal ligament fibroblasts under simulated orthodontic pressure
Creators: name: Groeger, Marcella
name: Spanier, Gerrit
name: Wolf, Michael
name: Deschner, James
name: Proff, Peter
name: Schröder, Agnes
name: Kirschneck, Christian
Publisher: name: Universität Regensburg
Year: 2020
Subjects: subject: H-1 RECEPTOR ANTAGONIST; FACTOR-KAPPA-B; TOOTH MOVEMENT; HPDL CELLS; RT-QPCR; EXPRESSION; CETIRIZINE; TISSUE; OSTEOCLASTOGENESIS; INTERLEUKIN-6;
subject: 610 Medizin

description: As type-I-allergies show an increasing prevalence in the general populace, orthodontic patients may also be affected by histamine release during treatment. Human periodontal ligament fibroblasts (PDLF) are regulators of orthodontic tooth movement. However, the impact of histamine on PDLF in this regard is unknown. Therefore PDLF were incubated without or with an orthodontic compressive force of 2g/cm(2)with and without additional histamine. To assess the role of histamine-1-receptor (H1R) H1R-antagonist cetirizine was used. Expression of histamine receptors and important mediators of orthodontic tooth movement were investigated. PDLF expressed histamine receptors H1R, H2R and H4R, but not H3R. Histamine increased the expression of H1R, H2R and H4R as well as of interleukin-6, cyclooxygenase-2, and prostaglandin-E2 secretion even without pressure application and induced receptor activator of NF-kB ligand (RANKL) protein expression with unchanged osteoprotegerin secretion. These effects were not observed in presence of H1R antagonist cetirizine. By expressing histamine receptors, PDLF seem to be able to respond to fluctuating histamine levels in the periodontal tissue. Increased histamine concentration was associated with enhanced expression of proinflammatory mediators and RANKL, suggesting an inductive effect of histamine on PDLF-mediated osteoclastogenesis and orthodontic tooth movement. Since cetirizine inhibited these effects, they seem to be mainly mediated via histamine receptor H1R.
Schrankia costaestrigalis
Creators: name: Fetnassi, Nidal
name: Er-rguibi, Omar
name: Aglagane, Abdessamad
name: Ghamizi, Mohamed
name: Õunap, Erki
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Erebidae
Schrankia
Schrankia costaestrigalis

description: Schrankia costaestrigalis (Stephens, 1834)
Notes
One specimen was found in Azgour.
description: Published as part of Fetnassi, Nidal, Er-rguibi, Omar, Aglagane, Abdessamad, Ghamizi, Mohamed & Õunap, Erki, 2025, Updates to the checklist of nocturnal Macroheterocera (Lepidoptera) of the Central High Atlas of Morocco: One new species added for Morocco, pp. e 137839 in Biodiversity Data Journal 13 on page e137839, DOI: 10.3897/BDJ.13.e137839
Eŭrazio ekde 1928 ĝis 1932 per biciklo kaj Esperanto : Eltiroj de ĉiuj personaj notoj (p. 67)
Creators: name: Péraire, Lucien
name: CNRS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023

description: Eltiraĵoj
Microtus (Alexandromys) limnophilus Büchner 1889
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Microtus
Microtus limnophilus

description: Microtus (Alexandromys) limnophilus Büchner 1889
Microtus (Alexandromys) limnophilus Büchner 1889, Wiss. Res. Przewalski Cent.-Asien Reisen, Zool., I: (Saugeth.): 110.
Type Locality: China, Qinghai.
Vernacular Names: Lacustrine Vole.
Synonyms: Microtus (Alexandromys) flaviventris Satunin 1903; Microtus (Alexandromys) malcolmi Thomas 1911; Microtus (Alexandromys) malygini Courant et al. 1999.
Distribution: NC China (from N Sichuan, E Qinghai, Gansu, and Shaanxi northeast through Ningxia to C Nei Mongol and NW Xinjiang; Zhang et al., 1997, as M. oeconomus) to W Mongolia.
Conservation: IUCN – Lower Risk (lc).
Discussion: Subgenus Alexandromys (including subgenus Pallasiinus sensu Zagorodnyuk, 1990, and Pavlinov et al., 1995 a). Formerly included in M. oeconomus (Corbet, 1978 c; Ellerman and Morrison-Scott, 1951), but Malygin et al. (1990, and references therein) separated limnophilus as a parapatric species in W Mongolia; further evidence of interspecific distinction and of intraspecific karyotypic variation presented by Courant et al. (1999). Correlation and interdependence among non-metric traits with sex, age, and body size discussed by Markowski (1995).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1004, DOI: 10.5281/zenodo.7316535
Significance of Extranodal Extension in Surgically Treated HPV-Positive Oropharyngeal Carcinomas
Creators: name: Beltz, Anna
name: Zimmer, Stefanie
name: Michaelides, Ioannis
name: Evert, Katja
name: Psychogios, Georgios
name: Bohr, Christopher
name: Künzel, Julian
Publisher: name: Universität Regensburg
Year: 2020
Subjects: subject: SQUAMOUS-CELL CARCINOMA; LYMPH-NODE METASTASES; EXTRACAPSULAR NEOPLASTIC SPREAD; HUMAN-PAPILLOMAVIRUS; COMPUTED-TOMOGRAPHY; PROGNOSTIC-FACTORS; DIAGNOSTIC-VALUE; NECK; HEAD; PREDICTOR; extranodal extension; TNM classification; human papilloma virus; oropharyngeal carcinoma; HPV; OPSCC
subject: 610 Medizin

description: Squamous cell carcinomas of the head and neck are the subject of numerous current studies, especially in view of the increasing incidence of tumors induced by human papillomavirus (HPV) and the latest changes to the TNM classification of oropharyngeal squamous cell carcinoma (OPSCC). In addition to HPV status, the presence of extranodal extension of lymph node metastases represents an important risk and prognostic factor, which has now been integrated into the staging algorithm of the eighth edition of TNM classification for HPV-negative OPSCC. In the past numerous studies had shown a lack of prognostic significance of extranodal extension in HPV-associated tumors. However, extranodal extension-as a possible risk factor even in HPV-positive OPSCC-remains an important subject of current studies, which are now particularly characterized by high numbers of cases. In this paper, diagnostic methods and the prognostic significance of extranodal extension in surgically treated HPV-positive OPSCC are presented and discussed based on relevant literature, and the results of current publications are summarized. Further development of diagnostic criteria and procedures as well as international standardization of clinical diagnostics of extranodal extension should be encouraged. Several studies demonstrate that extranodal extension results in worse survival outcomes even in HPV-positive tumors, in contrast to results of previous studies. Consequently, whether the prognostic significance of extranodal extension is not actually relevant to outcome and the staging algorithm of HPV-positive OPSCC should be questioned and further analyzed.
Litobopyrus longicaudatus Markham 1982
Creators: name: An, Jianmei
name: Boyko, Christopher B.
name: Li, Xinzheng
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Isopoda
Bopyridae
Litobopyrus
Litobopyrus longicaudatus

description: Litobopyrus longicaudatus Markham, 1982
Litobopyrus longicaudatus Markham, 1982: 346–348, fig. 15 [Hong Kong, infesting Athanas sp.]; Morton, 2003: 37; Li, 2003: 140, 153, 157.
MATERIAL EXAMINED: None.
HOSTS AND LOCALITIES: Infesting Athanas sp. (Alpheidae), Hong Kong.
REMARKS: The taxonomic position of L. longicatudatus is unclear, as the female characters are more like those of the bopyrine Urobopyrus Richardson, 1904, while the male characters more resemble those of the pseudionine Pleurocrypta Hesse, 1865.
description: Published as part of An, Jianmei, Boyko, Christopher B. & Li, Xinzheng, 2015, A Review Of Bopyrids (Crustacea: Isopoda: Bopyridae) Parasitic On Caridean Shrimps (Crustacea: Decapoda: Caridea) From China, pp. 1-85 in Bulletin of the American Museum of Natural History 2015 (399) on page 47, DOI: 10.1206/amnb-921-00-01.1, http://zenodo.org/record/4612506
Comparative assessment of mouse models for experimental orthodontic tooth movement
Creators: name: Kirschneck, Christian
name: Bauer, Maria
name: Gubernator, Joshua
name: Proff, Peter
name: Schröder, Agnes
Publisher: name: Universität Regensburg
Year: 2020
Subjects: subject: GINGIVAL CREVICULAR FLUID; K MESSENGER-RNA; CATHEPSIN-K; ROOT RESORPTION; HPDL CELLS; RAT; EXPRESSION; COMPRESSION; ACTIVATION; CYTOKINES;
subject: 610 Medizin

description: Animal experiments are essential for the elucidation of biological-cellular mechanisms in the context of orthodontic tooth movement (OTM). So far, however, no studies comparatively assess available mouse models regarding their suitability. OTM of first upper molars was induced in C57BL/6 mice either via an elastic band or a NiTi coil spring for three, seven or 12 days. We assessed appliance survival rate, OTM and periodontal bone loss (mu CT), root resorptions, osteoclastogenesis (TRAP(+) area) and local expression of OTM-related genes (RT-qPCR). Seven days after the elastic bands were inserted, 87% were still in situ, but only 27% after 12 days. Survival rate for the NiTi coil springs was 100% throughout, but 8.9% of the animals did not survive. Both methods induced significant OTM, which was highest after 12 (NiTi spring) and 7 days (band), with a corresponding increase in local gene expression of OTM-related genes and osteoclastogenesis. Periodontal bone loss and root resorptions were not induced at a relevant extent by neither of the two procedures within the experimental periods. To induce reliable OTM in mice beyond 7 days, a NiTi coil spring is the method of choice. The elastic band method is recommended only for short-term yes/no-questions regarding OTM.
Leptotyphlops reticulatus
Creators: name: Published, First
Publisher: name: Zenodo
Year: 2007
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Leptotyphlopidae
Leptotyphlops
Leptotyphlops reticulatus

description: Leptotyphlops reticulatus (Boulenger) (Plate 6, Fig. 2)
Reticulate worm-snake
Glauconia reticulata Boulenger, 1906, Ann. Mag. Nat. Hist. (7) 18: 441. Type locality: Wagga, Golis Mts, near Berbera, Somalia (10°00’N, 45°30’E, 900–1200 m), holotype BMNH 1946.1.16.53 (formerly BMNH 1905.11.7.42), collected by G.W. Bury; Boulenger, 1915c: 643.
Leptotyphlops reticulata — Parker, 1949: 19.
Leptotyphlops reticulatus — Hahn, 1978: 479, 1980: 24; Lanza, 1983: 220, 1990: 431; Meirte, 1992: 15; Broadley & Wallach, 1996: 162; Wallach, 1996: 429; McDiarmid et al., 1999: 40.
Diagnosis. This species is distinguished from Leptotyphlops boulengeri by its high middorsal and subcaudal counts and from L. drewesi by its broad rostral shield and reticulate colour pattern. Skull robust, with fused parietal bones (Plate 4, Fig 2D).
Description. Body cylindrical, with head broadened, flattened and distinct from neck, the moderate tail tapers to a small conical terminal spine.
Snout rounded, rostral moderate (0.35 head width), wider than nasals anteriorly, barely reaching level of eyes posteriorly, a deep preoral groove present ventrally but rostral not beaked or extending below lip line in lateral view. Behind rostral, upper lip bordered by an infranasal (nostril midway between rostral and supralabial along nasal suture), moderate anterior supralabial subequal in size to infranasal with width along lip equal to that of infranasal, large ocular with eye near upper anterior edge, and moderate posterior supralabial. Supraoculars twice as long as wide, anteriorly wedged between supranasal and ocular, posteriorly wedged between a large hexagonal frontal and a small postfrontal, which is followed by a larger and wider interparietal and a long but narrow interoccipital, the next middorsal scale is as wide as the interparietal. Parietals transverse, subequal to the enlarged occipitals, in contact with the moderate posterior supralabials. Temporal single. No mental.
Body covered with 14 rows of smooth, imbricate, subequal scales. Reduction to 10 rows on tail takes place lateral to the crescent-shaped cloacal shield. Total middorsals 227–238; subcaudals 29–32.
Total length/tail ratio 9.2–12.5; total length/diameter ratio 41–57.
Three to seven middorsal scale rows dark to light brown, each scale bordered with white, venter cream.
Size. Largest specimen (BMNH 1954.1.12.77 — Hargeisha, Somalia) has a total length of 201 mm.
Distribution. Highlands of northern Somalia, 900–1250 m (Plate 5).
Localities: SOMALIA. Hargeisha BMNH 1954.1.12.77*; Wagar, Golis Mts (Boulenger, 1906; Parker,1949) BMNH 1946.1.16.53.
description: Published as part of Published, First, 2007, A revision of the genus Leptotyphlops in northeastern Africa and southwestern Arabia (Serpentes: Leptotyphlopidae), pp. 1-78 in Zootaxa 1408 on pages 17-18, DOI: 10.5281/zenodo.6789060
Optimized Protocol for the In Situ Derivatization of Glutathione with N-Ethylmaleimide in Cultured Cells and the Simultaneous Determination of Glutathione/Glutathione Disulfide Ratio by HPLC-UV-QTOF-MS
Creators: name: Sun, Xueni
name: Berger, Raffaela
name: Heinrich, Paul
name: Marchiq, Ibtissam
name: Pouyssegur, Jacques
name: Renner, Kathrin
name: Oefner, Peter J.
name: Dettmer, Katja
Publisher: name: Universität Regensburg
Year: 2020
Subjects: subject: OXIDIZED GLUTATHIONE; LIQUID-CHROMATOGRAPHY; QUANTIFICATION; PROTEINS; TISSUES; PLASMA; EXPORT; ASSAY; GSSG; MCT1; glutathione; glutathione disulfide; cell culture; liquid chromatography; UV detection; mass spectrometry
subject: 610 Medizin

description: Glutathione (GSH) and glutathione disulfide (GSSG) are commonly used to assess the oxidative status of a biological system. Various protocols are available for the analysis of GSH and GSSG in biomedical specimens. In this study, we present an optimized protocol for the in situ derivatization of GSH withN-ethylmaleimide (NEM) to prevent GSH autooxidation, and thus to preserve the GSH/GSSG ratio during sample preparation. The protocol comprises the incubation of cells in NEM containing phosphate buffered saline (PBS), followed by metabolite extraction with 80% methanol. Further, to preserve the use of QTOF-MS, which may lack the linear dynamic range required for the simultaneous quantification of GSH and GSSG in non-targeted metabolomics, we combined liquid chromatographic separation with the online monitoring of UV absorbance of GS-NEM at 210 nm and the detection of GSSG and its corresponding stable isotope-labeled internal standard by QTOF-MS operated with a 10 Da Q1 window. The limit of detection (LOD) for GS-NEM was 7.81 mu M and the linear range extended from 15.63 mu M to 1000 mu M with a squared correlation coefficientR(2)of 0.9997. The LOD for GSSG was 0.001 mu M, and the lower limit of quantification (LLOQ) was 0.01 mu M, with the linear (R-2= 0.9994) range extending up to 10 mu M. The method showed high repeatability with intra-run and inter-run coefficients of variation of 3.48% and 2.51% for GS-NEM, and 3.11% and 3.66% for GSSG, respectively. Mean recoveries of three different spike-in levels (low, medium, high) of GSSG and GS-NEM were above 92%. Finally, the method was applied to the determination of changes in the GSH/GSSG ratio either in response to oxidative stress in cells lacking one or both monocarboxylate transportersMCT1andMCT4, or in adaptation to the NADPH (nicotinamide adenine dinucleotide phosphate) consuming production of D-2-hydroxyglutarate in cells carrying mutations in the isocitrate dehydrogenase genesIDH1andIDH2.
Fasudil Loaded PLGA Microspheres as Potential Intravitreal Depot Formulation for Glaucoma Therapy
Creators: name: Mietzner, Raphael
name: Kade, Christian
name: Froemel, Franziska
name: Pauly, Diana
name: Stamer, W. Daniel
name: Ohlmann, Andreas
name: Wegener, Joachim
name: Fuchshofer, Rudolf
name: Breunig, Miriam
Publisher: name: Universität Regensburg
Year: 2020
Subjects: subject: PROTEIN-KINASE INHIBITOR; DRUG-DELIVERY; INTRAOCULAR-PRESSURE; AQUEOUS-HUMOR; PARTICLE-SIZE; RELEASE; CELLS; Y-27632; MODEL; DEXAMETHASONE; drug delivery; glaucoma; ROCK inhibitor; fasudil; PLGA microspheres; intravitreal injection; trabecular meshwork; Schlemm's canal; retinal pigment epithelium; Electric Cell-Substrate Impedance Sensing
subject: 540 Chemie
subject: 570 Biowissenschaften, Biologie
subject: 610 Medizin
subject: 615 Pharmazie

description: Rho-associated protein kinase (ROCK) inhibitors allow for causative glaucoma therapy. Unfortunately, topically applied ROCK inhibitors suffer from high incidence of hyperemia and low intraocular bioavailability. Therefore, we propose the use of poly (lactide-co-glycolide) (PLGA) microspheres as a depot formulation for intravitreal injection to supply outflow tissues with the ROCK inhibitor fasudil over a prolonged time. Fasudil-loaded microspheres were prepared by double emulsion solvent evaporation technique. The chemical integrity of released fasudil was confirmed by mass spectrometry. The biological activity was measured in cell-based assays using trabecular meshwork cells (TM cells), Schlemm's canal cells (SC cells), fibroblasts and adult retinal pigment epithelium cells (ARPE-19). Cellular response to fasudil after its diffusion through vitreous humor was investigated by electric cell-substrate impedance sensing. Microspheres ranged in size from 3 to 67 mu m. The release of fasudil from microspheres was controllable and sustained for up to 45 days. Released fasudil reduced actin stress fibers in TM cells, SC cells and fibroblasts. Decreased collagen gel contraction provoked by fasudil was detected in TM cells (similar to 2.4-fold), SC cells (similar to 1.4-fold) and fibroblasts (similar to 1.3-fold). In addition, fasudil readily diffused through vitreous humor reaching its target compartment and eliciting effects on TM cells. No negative effects on ARPE-19 cells were observed. Since fasudil readily diffuses through the vitreous humor, we suggest that an intravitreal drug depot of ROCK inhibitors could significantly improve current glaucoma therapy particularly for patients with comorbid retinal diseases.
Parascotia nisseni
Creators: name: Fetnassi, Nidal
name: Er-rguibi, Omar
name: Aglagane, Abdessamad
name: Ghamizi, Mohamed
name: Õunap, Erki
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Erebidae
Parascotia
Parascotia nisseni

description: Parascotia nisseni (Turati, 1905)
Notes
One specimen was collected from Taddart.
description: Published as part of Fetnassi, Nidal, Er-rguibi, Omar, Aglagane, Abdessamad, Ghamizi, Mohamed & Õunap, Erki, 2025, Updates to the checklist of nocturnal Macroheterocera (Lepidoptera) of the Central High Atlas of Morocco: One new species added for Morocco, pp. e 137839 in Biodiversity Data Journal 13 on page e137839, DOI: 10.3897/BDJ.13.e137839
Eublemma ostrina
Creators: name: Fetnassi, Nidal
name: Er-rguibi, Omar
name: Aglagane, Abdessamad
name: Ghamizi, Mohamed
name: Õunap, Erki
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Eublemma
Eublemma ostrina

description: Eublemma ostrina (Hübner, 1808)
Notes
One specimen was collected from Tamal.
description: Published as part of Fetnassi, Nidal, Er-rguibi, Omar, Aglagane, Abdessamad, Ghamizi, Mohamed & Õunap, Erki, 2025, Updates to the checklist of nocturnal Macroheterocera (Lepidoptera) of the Central High Atlas of Morocco: One new species added for Morocco, pp. e 137839 in Biodiversity Data Journal 13 on page e137839, DOI: 10.3897/BDJ.13.e137839
Introduction to the Latin papyri from Herculaneum: Drafts of an unpublished article.
Creators: name: Marichal, Robert
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015

description: vue 10
description: "Typed drafts of an unpublished article on Latin papyri from Herculaneum with handwritten notes and bibliographical updatings. The working title ('P. Hercul. Lat. Introduction'), the place of composition (Princeton, 1961) and the date of the last revision of the material ('Non publié (1993)') are written on the folder. - Bibliographical annotations on Roman History, later than 1961. – Annotations on palaeography and technical vocabulary of Herculanean papyrology. – Detailed annotations on the Piso family from an unnamed study by R. Syme (possibly The Augustan Aristocracy (1986). - Thematic sections are typed in the upper right corner of the sheet: bibliography, history, unrolling, state of conservation, Philodemus, the Piso family; number of pages are pencil-written in the upper right corner of each page."
description: Source: 4MAR_8_2_5-5
description: created: "n.d., [1961; 1993]"
Robust and efficient factorial designs under baseline parametrization
Creators: name: Liu, Yu
name: Ren, Min
name: Zhao, Shengli
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy

description: Factorial designs, traditionally based on orthogonal parametrization, are widely used to study the effects of factors on responses. While the baseline parametrization has more applicability in many cases compared to the orthogonal parametrization, constructing baseline parametrization design is still challenging. This article presents a method based on approximation theory to search for highly efficient baseline parametrization designs, enhancing the accuracy of factor effect estimations. In addition, this article employs the D-optimal minimax criterion to ensure the robustness of the design. The examples and simulation show that the constructed designs have high efficiency.
title: Historia delle guerre civili di Francia di Henrico Caterino Davila...
Creators: name: Davila, Enrico Caterino
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2019

description: Source: Bibliothèque patrimoniale Villon (Rouen), U 1252
Protocol of a retrospective, multicentre observational study on hyperthermic intrathoracic chemotherapy in Germany
Creators: name: Markowiak, Till
name: Koller, Michael
name: Zeman, Florian
name: Huppertz, Gunnar
name: Hofmann, Hans-Stefan
name: Ried, Michael
Publisher: name: Universität Regensburg
Year: 2020
Subjects: subject: 610 Medizin

description: Introduction 
Objective of the ‘German hyperthermic intrathoracic chemotherapy (HITOC) study’ is to evaluate the HITOC as additional treatment after surgical cytoreduction for malignant pleural tumours. Even though HITOC is applied with increasing frequency, there is no standardised therapy protocol concerning the technique of HITOC, the selection as well as dosage of chemotherapeutic agents and perioperative management in order to provide a safe and comparable, standardised treatment regime.

Methods and analysis 
This trial is a retrospective, multicentre observational study, which is funded by the German Research Foundation. Approximately 300 patients will be included. Four departments of thoracic surgery, which are performing the most HITOC procedures in Germany, are contributing to this study: Center for Thoracic Surgery at the University Hospital Regensburg, Thoracic Clinic Heidelberg of the University of Heidelberg, Center for Thoracic Surgery of the Hospital University of Munich and the Department of Thoracic Surgery at the University Hospital Freiburg. All patients who underwent surgical cytoreduction and subsequent HITOC at one of the four centres between starting the HITOC programme in 2008 and December 2019 will be included. Information on the performed HITOC will be obtained, focusing on the technique as well as the applied perfusion solution including the chemotherapeutic agent. Furthermore, parameters of the patient’s postoperative recovery will be analysed to determine 30-day morbidity and mortality.
title: Madame Firmiani, dans La Comédie humaine, Paris, Furne, 1842, t. I, Études de mœurs, Scènes de la vie privée, p. 231-250
Creators: name: de Balzac, Honoré
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021
Subjects: subject: Balzac
subject: e-Balzac
subject: Comédie humaine
subject: Furne
subject: Édition numérique
subject: Madame Firmiani
subject: Roman
subject: 19e siècle
subject: Roman français
subject: Réalisme (mouvement littéraire)
subject: Édition en ligne
subject: Édition électronique
subject: Édition en libre accès

description: Cette édition électronique propose le texte de l’édition originale de La Comédie humaine parue chez Furne de 1842 à 1847. Cette édition a été établie dans le cadre du projet PHŒBUS, financé par l’Agence nationale de la recherche (2015-2019).
description: Relation: https://nakala.fr/10.34847/nkl.fcc0njl0
description: Qui est donc madame Firmiani ? On dit qu’Octave de Camps s’est ruiné pour elle ! L’oncle d’Octave, monsieur de Bourbonne, un oncle à héritage, mène sa propre enquête, jusque dans le salon de madame Firmiani qui n’accepte chez elle que des gens de qualité.
description: available: https://www.ebalzac.com/edition/11-madame-firmiani/furne
Manifold nº 6 (U.R.S.S. nº 4) (p. 82)
Creators: name: Péraire, Lucien
name: CNRS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023

description: ......Ce qui justifie le but de mon voyage: comment éviter et prévenir pareil cataclysme ?
Role of Oxygen Supply in Macrophages in a Model of Simulated Orthodontic Tooth Movement
Creators: name: Schröder, Agnes
name: Barschkies, Leonie
name: Jantsch, Jonathan
name: Proff, Peter
name: Gölz, Lina
name: Deschner, James
name: Kirschneck, Christian
Publisher: name: Universität Regensburg
Year: 2020
Subjects: subject: VALID GENE-EXPRESSION; HPDL CELLS; RT-QPCR; HYPOXIA; INFLAMMATION; HIF-1; FOCUS;
subject: 610 Medizin

description: Apart from periodontal ligament fibroblasts, immune cells like macrophages also play an important mediating role in orthodontic tooth movement (OTM). Upon orthodontic force application to malpositioned teeth, macrophages in the periodontal ligament get exposed to both mechanical strain and hypoxic conditions (via a compression of blood vessels). In this study, we assessed the relative impact of orthodontically induced mechanical strain and hypoxic conditions on macrophages for the mediation and regulation of OTM. Macrophages were stimulated with physiological orthodontic compressive forces of 2 g/cm(2) for 4 h and 24 h on gas-impermeable or gas-permeable cell culture plates under normoxic or hypoxic cell culture conditions. We quantified expression of genes involved in inflammation (Tnf,Il-6, andCox-2), extracellular remodelling (Mmp-9), and angiogenesis (Vegf) by RT-qPCR. Furthermore, we analysed HIF-1 alpha, prostaglandin-E2, and VEGF protein expression via immunoblotting or ELISA. Mechanical strain and oxygen supply both differentially affected expression of genes and proteins involved in inflammation and angiogenesis. In this context, we found that HIF-1 alpha protein levels were elevated by combined mechanical strain and hypoxic conditions, whereas gas-permeable plates providing sufficient oxygen supply prevented HIF-1 alpha stabilization at the protein level after pressure application on macrophages. Our results thus indicate that macrophages involved in the mediation of OTM are affected by and respond differently to hypoxic conditions and mechanical compressive strain, which occur concomitantly during OTM, than periodontal ligament fibroblasts (PDLF), thus indicating different roles of these cells in the regulation of OTM at the cellular-molecular level. We further observed that contrary to PDLF HIF-1 alpha stabilization in macrophages is rather induced via the decreased oxygen supply associated with OTM than via mechanotransduction by mechanical strain.
Microtus (Terricola) lusitanicus Gerbe 1879
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Microtus
Microtus lusitanicus

description: Microtus (Terricola) lusitanicus Gerbe 1879
Microtus (Terricola) lusitanicus Gerbe 1879, Rev. Mag. Zool. Paris, ser. 3, 7: 44.
Type Locality: Portugal.
Vernacular Names: Lusitanian Pine Vole.
Synonyms: Microtus (Terricola) depressus (Miller 1908); Microtus (Terricola) gerritmilleri Kretzoi 1958; Microtus (Terricola) hurdanensis (Agacino 1938); Microtus (Terricola) mariae Major 1905; Microtus (Terricola) pelandonius (Miller 1908).
Distribution: Portugal, N and C Spain (Brunet-Lecomte, 1991; Castien and Gosalbez, 1992), and SW France.
Conservation: IUCN – Lower Risk (lc).
Discussion: Subgenus Terricola, duodecimcostatus species group (Chaline et al., 1988). Graf (1982) and Chaline and Graf (1988) apparently used mariae for this species, which reflected Winking’s (1976) opinion in separating the latter from M. duodecimcostatus; Niethammer (1982 j) explained the priority of lusitanicus. Chromosomal data reviewed by Zima and Kral (1984 a). Morphometric analyses of variation within M. lusitanicus and multivariate contrasts with M. duodecimcostatus and-or M. gerbii conducted by Spitz (1978) and Mathias (1996). Brunet-Lecomte and Povoas (1993) successfully separated isolated molars of M. lusitanicus and M. duodecimcostatus using morphometric analyses of extant and Upper Palaeolithic-Neolithic samples in C Portugal. The fossorial M. lusitanicus is an adept swimmer (Giannoni et al., 1993), like its fossorial relative M. duodecimcostatus (Giannoni et al., 1994), an ability facilitating dispersal in mountainous habitats dissected by numerous streams.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1004, DOI: 10.5281/zenodo.7316535
Metachrostis velox
Creators: name: Fetnassi, Nidal
name: Er-rguibi, Omar
name: Aglagane, Abdessamad
name: Ghamizi, Mohamed
name: Õunap, Erki
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Noctuidae
Metachrostis
Metachrostis velox

description: Metachrostis velox (Hübner, 1813)
Notes
Four specimens were collected from Ait Ouiksane and Tamal.
description: Published as part of Fetnassi, Nidal, Er-rguibi, Omar, Aglagane, Abdessamad, Ghamizi, Mohamed & Õunap, Erki, 2025, Updates to the checklist of nocturnal Macroheterocera (Lepidoptera) of the Central High Atlas of Morocco: One new species added for Morocco, pp. e 137839 in Biodiversity Data Journal 13 on page e137839, DOI: 10.3897/BDJ.13.e137839
Leptotyphlops drewesi Wallach 1996
Creators: name: Published, First
Publisher: name: Zenodo
Year: 2007
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Leptotyphlopidae
Leptotyphlops
Leptotyphlops drewesi

description: Leptotyphlops drewesi Wallach (Plate 6, Fig. 4)
Drewes’ worm snake
Leptotyphlops drewesi Wallach, 1996, J. Afr. Zool. 110: 426, fig. 1. Type locality: northern base of Mount Kenya, 10 km south of Isiolo, Eastern Region, Kenya (0°21’N, 37°35’E, elevation ca. 1400 m), holotype CAS 85756, collected by R.E. Leach & E.S. Ross, 26 November 1957; McDiarmid et al., 1999: 28; Spawls et al., 2002: 301.
Diagnosis. A member of the Leptotyphlops reticulatus species group, differing from both other species in its small bulbous rostral, high middorsal count (248 vs 179–192 and 227–238 respectively) and colouration.
Description. Body cylindrical, with head and neck broadened and flattened, the short tail tapers abruptly to a large thorn-like apical spine, recurved ventrally.
Snout rounded, rostral narrow (0.33 head width) and short, subequal in width to nasals anteriorly, but slightly bulbous and protruding, not reaching interocular level posteriorly. Behind rostral, upper lip bordered by small infranasal (nostril midway between rostral and supralabial along nasal suture), moderate anterior supralabial that extends dorsally beyond level of the nostril with a width along lip twice that of infranasal, large ocular with a moderate eye with a distinct pupil near the upper anterior edge, and moderate posterior supralabial. Supraoculars pentagonal, anteriorly wedged between upper nasal and ocular, posteriorly wedged between a subequal hexagonal frontal and pentagonal postfrontal, interparietal absent, interoccipital much larger than the frontal and postfrontal. Parietals transverse, in contact with the posterior supralabials, subequal to the enlarged occipitals, which are in contact medially. Temporal single. No mental.
Body covered with 14 rows of smooth, imbricate scales, the vertebral row slightly enlarged, reduced to 10 rows on tail. Total middorsals 248, subcaudals 26.
Total length/diameter ratio 41; total length/tail length ratio 11.9.
Bicoloured, with five light brown middorsal scale rows, a midlateral lightly pigmented row and seven immaculate creamy-white ventral rows, a light nuchal collar (ca. 2 scales wide), broken on the vertebral line, lower snout and upper lip white.
Size. Length of holotype 131 + 12 = 143 mm, midbody diameter 3.5 mm.
Distribution. Only known from the type locality on the ecotone between the semi-arid steppe of the Somali Arid zone and the wooded and open grassland of northern Mount Kenya, 1400 m (Plate 5). This consists of steep slopes with short grasses and scattered low thorn trees (Acacia).
description: Published as part of Published, First, 2007, A revision of the genus Leptotyphlops in northeastern Africa and southwestern Arabia (Serpentes: Leptotyphlopidae), pp. 1-78 in Zootaxa 1408 on page 19, DOI: 10.5281/zenodo.6789060