cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Habenaria palpensis Raskoti 2019, sp. nov.
Creators: name: Raskoti, Bhakta Bahadur
name: Ale, Rita
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Habenaria
Habenaria palpensis

description: Habenaria palpensis Raskoti sp. nov. Figs. 3 and 4.
 Type:— Nepal, Palpa District, Mujhung, at an altitude of 1500 m, 4 Sept. 2009, Raskoti Bhakta B. 00999 (holotype: KATH).
 Diagnosis: Habenaria palpensis is closely related to Habenaria rostrata (Lindley 1835: 325) but differs in having lateral sepals not reflexed and blotched brown, lateral lobe of lip not divaricate, spur geniculate and longer than ovary and pedicel.
Herb terrestrial, whole plant 45 cm tall. Stem sheathed, cylindrical with 2 spaced leaves, and four bracts above leaves. Leaves 2, alternate, ovate-lanceolate, 3.5–5.5 × 1.5–2.0 cm, apex acute, margin entire. Inflorescence racemose; peduncle 25–30 cm, rachis 4 cm with 5–6 suberect lax flowers; floral bracts 2 cm long, lanceolate, apex acuminate. Ovary 2 cm long, twisted. Flower half opened, 1 cm across, white with upper part of sepals, and midlobe of lip flushed light green. Dorsal sepal 7 × 2 mm, 3-veined, oblong-lanceolate, concave, curved, 3-lobed from above middle, lateral lobe small, rounded, mid lobe triangular, apex acute; lateral sepals 8 × 4 mm, obliquely ovate-lanceolate, curved, 3-veined, apex acuminate. Petals 4 × 1 mm, adnate to the column wings, oblong, 1-veined, apex obtuse. Lip 1 cm long and ca. 3 mm wide, base with ring shaped collar, 3-lobed above base, lateral lobes 5.0 × 0.5 mm, filiform, acuminate, mid lobe oblong, 7 × 2 mm, 1-veined, apex obtuse, spur 25 mm long, longer than ovary, geniculate, apex clavate. Column 2 mm, auricle 1 mm, caudicles 2 mm long, pollinia ellipsoid, stigma oblong, ca. 2 mm.
 Flowering time: —August–September.
 Habit, habitat and distribution: —Terrestrial in open moist shady grassland slopes in floor of Pine forest. Taxon is known only from type locality in central Nepal at an altitude of 1500 meters.
 Etymology: — Habenaria palpensis is the name of the type locality Palpa district.
 Notes: — Habenaria palpensis is close to Habenaria rostrata, with which it shares the ring-shaped collar near mouth of spur (Chen et al. 2009, Pedersen et al. 2011). It is distinguished from H. rostrata by 3-lobed oblong-lanceolate dorsal sepal, apex acute, lateral sepals not reflexed and blotched brown, apex acute, lateral lobe of lip not divaricate, spur geniculate and longer than pedicel and ovary.
 Habenaria palpensis is also similar to Habenaria rostellifera (Reichenbach 1878: 34) in its spur shape, but the later has reflexed lateral sepals with dark brown blotched and divaricated lateral lobes of lip. Moreover, H. rostellifera has 3-toothed subcylindric lamella near mouth of spur.
description: Published as part of Raskoti, Bhakta Bahadur & Ale, Rita, 2019, New species of orchids and notes on Orchidaceae of Nepal, pp. 257-266 in Phytotaxa 394 (4) on page 260, DOI: 10.11646/phytotaxa.394.4.3, http://zenodo.org/record/13718521
Ice Age : Chemo-dynamical modeling of Cha-MMS1 to predict new solid-phase species for detection with JWST
Creators: name: Jin, Mihwa
name: Lam, Ka Ho
name: McClure, Melissa K.
name: van Scheltinga, Jeroen Terwisscha
name: Li, Zhi-Yun
name: Boogert, Adwin
name: Herbst, Eric
name: Davis, Shane W.
name: Garrod, Robin T.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Chemical models and experiments indicate that interstellar dust grains and their ice mantles play an important role in the production of complex organic molecules (COMs). To date, the most complex solid-phase molecule detected with certainty in the ISM is methanol, but the James Webb Space Telescope (JWST) may be able to identify still larger organic species. In this study, we use a coupled chemo-dynamical model to predict new candidate species for JWST detection toward the young star-forming core Cha-MMS1, combining the gas-grain chemical kinetic code MAGICKAL with a 1-D radiative hydrodynamics simulation using Athena++. With this model, the relative abundances of the main ice constituents with respect to water toward the core center match well with typical observational values, providing a firm basis to explore the ice chemistry. Six oxygen-bearing COMs (ethanol, dimethyl ether, acetaldehyde, methyl formate, methoxy methanol, and acetic acid), as well as formic acid, show abundances as high as, or exceeding, 0.01% with respect to water ice. Based on the modeled ice composition, the infrared spectrum is synthesized to diagnose the detectability of the new ice species. The contribution of COMs to IR absorption bands is minor compared to the main ice constituents, and the identification of COM ice toward the core center of Cha-MMS1 with the JWST NIRCAM/Wide Field Slitless Spectroscopy (2.4-5.0 micron) may be unlikely. However, MIRI observations (5-28 micron) toward COM-rich environments where solid-phase COM abundances exceed 1% with respect to the water ice column density might reveal the distinctive ice features of COMs.
description: Accepted to ApJ (28 Pages, 11 figures)
Quality Control in Crowdsourced Object Segmentation
Creators: name: Cabezas, Ferran
name: Carlier, Axel
name: Salvador, Amaia
name: Giró-i-Nieto, Xavier
name: Charvillat, Vincent
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: This paper explores processing techniques to deal with noisy data in crowdsourced object segmentation tasks. We use the data collected with "Click'n'Cut", an online interactive segmentation tool, and we perform several experiments towards improving the segmentation results. First, we introduce different superpixel-based techniques to filter users' traces, and assess their impact on the segmentation result. Second, we present different criteria to detect and discard the traces from potential bad users, resulting in a remarkable increase in performance. Finally, we show a novel superpixel-based segmentation algorithm which does not require any prior filtering and is based on weighting each user's contribution according to his/her level of expertise.
description: Paper accepted at the IEEE International Conference on Image Processing (ICIP) 2015. Quebec City, 27-30 September 2015
Invariant features of spatial inequality in consumption: the case of India
Creators: name: Chatterjee, Arnab
name: Chakrabarti, Anindya S.
name: Ghosh, Asim
name: Chakraborti, Anirban
name: Nandi, Tushar K.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics and Society (physics.soc-ph)
subject: General Economics (econ.GN)
subject: FOS: Physical sciences
subject: FOS: Economics and business

description: We study the distributional features and inequality of consumption expenditure across India, for different states, castes, religion and urban-rural divide. We find that even though the aggregate measures of inequality are fairly diversified across states, the consumption distributions show near identical statistics, once properly normalized. This feature is seen to be robust with respect to variations in sociological and economic factors. We also show that state-wise inequality seems to be positively correlated with growth which is in accord with the traditional idea of Kuznets' curve. We present a brief model to account for the invariance found empirically and show that better but riskier technology draws can create a positive correlation between inequality and growth.
description: 14 pages, 5 figs, 4 tables; Accepted in Physica A
The empirical process of residuals from an inverse regression
Creators: name: Kutta, Tim
name: Bissantz, Nicolai
name: Chown, Justin
name: Dette, Holger
Publisher: name: Technische Universität Dortmund
Year: 2019
Subjects: subject: indirect regression model
subject: empirical process
subject: Radon transform
subject: inverse problems
subject: 310
subject: 330
subject: 620
subject: Regressionsanalyse
subject: Approximative Inverse
subject: Radon-Transformation

description: In this paper we investigate an indirect regression model characterized by the Radon transformation. This model is useful for recovery of medical images obtained by computed tomography scans. The indirect regression function is estimated using a series estimator motivated by a spectral cut-off technique. Further, we investigate the empirical process of residuals from this regression, and show that it satsifies a functional central limit theorem.
description: Discussion Paper / SFB823;02/2019
Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitor Agents: Optimization of Diarylanilines with High Potency against Wild-Type and Rilpivirine-Resistant E138K Mutant Virus
Creators: name: Jiang, Shibo
name: Liu, Na
name: Qin, Bingjie
name: Yu, Fei
name: Lee, Kuo-Hsiung
name: Wei, Lei
name: Zhu, Dong-Qin
name: Zheng, Weifan
name: Chen, Chin-Ho
name: Morris-Natschke, Susan L.
name: Huang, Li
name: Xie, Lan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Three series (6, 13, and 14) of new diarylaniline (DAAN) analogues were designed, synthesized, and evaluated for anti-HIV potency, especially against the E138K viral strain with a major mutation conferring resistance to the new-generation non-nucleoside reverse transcriptase inhibitor drug rilpivirine (1b). Promising new compounds were then assessed for physicochemical and associated pharmaceutical properties, including aqueous solubility, log P value, and metabolic stability, as well as predicted lipophilic parameters of ligand efficiency, ligand lipophilic efficiency, and ligand efficiency-dependent lipophilicity indices, which are associated with ADME property profiles. Compounds 6a, 14c, and 14d showed high potency against the 1b-resistant E138K mutated viral strain as well as good balance between anti-HIV-1 activity and desirable druglike properties. From the perspective of optimizing future NNRTI compounds as clinical trial candidates, computational modeling results provided valuable information abo...
Additional file 1 of Population genetic analyses inferred a limited genetic diversity across the pvama-1 DI domain among Plasmodium vivax isolates from Khyber Pakhtunkhwa regions of Pakistan
Creators: name: Ullah, Ibrar
name: Afridi, Sahib Gul
name: Israr, Muhammad
name: Khan, Hizbullah
name: Shams, Sulaiman
name: Zaib, Komal
name: Le, Huong Giang
name: Kang, Jung-Mi
name: Na, Byoung-Kuk
name: Khan, Asifullah
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Fig S1. Frequency of different haplotypes detected in pvama-1 DI of P. vivax samples collected from different districts of KP, Pakistan
Energy Dependence of Intrinsic Charm Production: What is the Best Energy for Observation?
Creators: name: Vogt, R.
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Background: A nonperturbative charm production contribution, known as intrinsic charm, was predicted in the early 1980s. Recent results have provided new evidence for its existence but further confirmation is needed. Purpose: $J/ψ$ and $\bar D$ meson production are calculated with a combination of perturbative QCD and intrinsic charm to determine the best energy range to study intrinsic charm production. Methods: $J/ψ$ and $\bar D$ meson production are calculated in perturbative QCD to next-to-leading order in the cross section. Cold nuclear matter effects, including nuclear modification of the parton densities and $p_T$ broadening by multiple scattering are taken into account in the production of both; absorption by nucleons is also included for the $J/ψ$. Contributions from intrinsic charm are calculated assuming production from a $|uud c \bar c \rangle$ Fock state. Results: The $J/ψ$ and $\bar D$ meson rapidity and $p_T$ distributions are calculated as a function of rapidity and transverse momentum $p_T$ over a wide range of center-of-mass energies with and without intrinsic charm in $p+p$ collisions. The nuclear modification factor, $R_{pA}$, is also calculated for $p+{\rm Pb}$ interactions at appropriate energies. Previous fixed-target data as a function of Feynman $x$, $x_F$, are also compared to calculations within the approach. Good agreement with the data is found when intrinsic charm is included. Conclusions: The intrinsic charm signal may be largest at midrapidity for future low energy fixed target experiments such as the proposed NA60+.
description: 32 pages, 16 figures
Reconfiguration and eruption of a solar filament by magnetic reconnection with an emerging magnetic field
Creators: name: Li, Leping
name: Peter, Hardi
name: Chitta, Lakshmi Pradeep
name: Song, Hongqiang
name: Xu, Zhe
name: Xiang, Yongyuan
Publisher: name: arXiv
Year: 2022
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: Both observations and simulations suggest that the solar filament eruption is closely related to magnetic flux emergence. It is thought that the eruption is triggered by magnetic reconnection between the filament and the emerging flux. However, the details of such a reconnection are rarely presented. In this study, we report the detailed reconnection between a filament and its nearby emerging fields, that led to the reconfiguration and subsequent partial eruption of the filament located over the polarity inversion line of active region 12816. Before the reconnection, we observed repeated brightenings in the filament at a location that overlies a site of magnetic flux cancellation. Plasmoids form at this brightening region, and propagate bi-directionally along the filament. These indicate the tether-cutting reconnection that results in the formation and eruption of a flux rope. To the northwest of the filament, magnetic fields emerge, and reconnect with the context ones, resulting in repeated jets. Afterwards, another magnetic fields emerge near the northwestern filament endpoints, and reconnect with the filament, forming the newly reconnected filament and loops. Current sheet repeatedly occurs at the interface, with the mean temperature and emission measure of 1.7 MK and 1.1$\times$10$^{28}$ cm$^{-5}$. Plasmoids form in the current sheet, and propagate along it and further along the newly reconnected filament and loops. The newly reconnected filament then erupts, while the unreconnected filament remains stable. We propose that besides the orientation of emerging fields, some other parameters, such as the position, distance, strength, and area, are also crucial for triggering the filament eruption.
description: 15 pages, 7 figures, accepted for publication in ApJ
A physical model for the UV/optical power spectra of AGN
Creators: name: Panagiotou, Christos
name: Papadakis, Iossif
name: Kara, Erin
name: Kammoun, Elias
name: Dovčiak, Michal
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The UV/optical variability of AGN has long been thought to be driven by the X-ray illumination of the accretion disk. However, recent multi-wavelength campaigns of nearby Seyfert galaxies seem to challenge this paradigm, with an apparent discrepancy between observations and the underlying theory. In order to further probe the connection between the UV/optical and X-ray variability in AGN we developed a physical model to reproduce the UV/optical power spectra (PSDs) of AGN assuming the thermal reprocessing of the X-rays in the disk. This model offers a novel way to probe the innermost regions of AGN. We use our model to study the variability of NGC 5548 and we infer that the X-ray and UV/optical PSDs as well as the interband UV/optical time lags are all well reproduced. We also derive constraints on the source physical parameters, such as the X-ray corona height and the accretion rate. Our results suggest that X-ray disk reprocessing accounts for the full variability properties of this AGN, within the considered time scales. Using earlier data of NGC 5548, we also show that our model can reproduce its PSD in different epochs, establishing the feasibility of using PSD modelling to investigate the time evolution of a source.
description: 15 (+11 in Appendix) pages, 12 figures, accepted for publication by ApJ
Mass anomalous dimension of Adjoint QCD at large N from twisted volume reduction
Creators: name: Pérez, Margarita García
name: González-Arroyo, Antonio
name: Keegan, Liam
name: Okawa, Masanori
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: In this work we consider the $SU(N)$ gauge theory with two Dirac fermions in the adjoint representation, in the limit of large $N$. In this limit the infinite-volume physics of this model can be studied by means of the corresponding twisted reduced model defined on a single site lattice. Making use of this strategy we study the reduced model for various values of $N$ up to 289. By analyzing the eigenvalue distribution of the adjoint Dirac operator we test the conformality of the theory and extract the corresponding mass anomalous dimension.
description: 17 pages, 11 figures. Version to appear in JHEP - corrected typos and references
The physical origin for spatially large scatter of IGM opacity at the end of reionization: the IGM Ly$α$ opacity-galaxy density relation
Creators: name: Ishimoto, Rikako
name: Kashikawa, Nobunari
name: Kashino, Daichi
name: Ito, Kei
name: Liang, Yongming
name: Cai, Zheng
name: Yoshioka, Takehiro
name: Okoshi, Katsuya
name: Misawa, Toru
name: Onoue, Masafusa
name: Takeda, Yoshihiro
name: Uchiyama, Hisakazu
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The large opacity fluctuations in the $z > 5.5$ Ly$α$ forest may indicate inhomogeneous progress of reionization. To explain the observed large scatter of the effective Ly$α$ optical depth ($τ_{\rm eff}$) of the intergalactic medium (IGM), fluctuation of UV background ($Γ$ model) or the IGM gas temperature ($T$ model) have been proposed, which predict opposite correlations between $τ_{\rm eff}$ and galaxy density. In order to address which model can explain the large scatter of $τ_{\rm eff}$, we search for Ly$α$ emitters (LAEs) around two (J1137+3549 and J1602+4228) quasar sightlines with $τ_{\rm eff}\sim3$ and J1630+4012 sightline with $τ_{\rm eff}\sim5.5$. Using a narrowband imaging with Subaru/Hyper Suprime-Cam, we draw LAE density maps to explore their spatial distributions. Overdensities are found within 20 $h^{-1}$Mpc of the quasar sightlines in the low $τ_{\rm eff}$ regions, while a deficit of LAEs is found in the high $τ_{\rm eff}$ region. Although the $τ_{\rm eff}$ of the three quasar sightlines are neither high nor low enough to clearly distinguish the two models, these observed $τ_{\rm eff}$-galaxy density relations all consistently support the $Γ$ model rather than the $T$ model in the three fields, along with the previous studies. The observed overdensities near the low $τ_{\rm eff}$ sightlines may suggest that the relic temperature fluctuation does not affect reionization that much. Otherwise, these overdensities could be attributed to other factors besides the reionization process, such as the nature of LAEs as poor tracers of underlying large-scale structures.
description: 13 pages, 14 figures, accepted for publication in MNRAS
Fermiophobic light Higgs boson in the type-I two-Higgs-doublet model
Creators: name: Kim, Jinheung
name: Lee, Soojin
name: Sanyal, Prasenjit
name: Song, Jeonghyeon
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The null results in the new physics searches at the LHC do not exclude an intermediate-mass new particle if it is fermiophobic. Type-I in the two-Higgs-doublet model accommodates a fermiophobic light Higgs boson $h_{\rm f}$ if $α=π/2$. The heavier $CP$-even Higgs boson explains the observed Higgs boson at a mass of 125 GeV. We first obtain the still-valid parameter space satisfying the theoretical requirements, flavor-changing neutral currents in $B$ physics, the cutoff scale above 1 TeV, Higgs precision data, and the direct collider search bounds at high energy colliders. We also study the high energy scale behavior via the analysis of the renormalization group equations. An important result is that the fermiophobic type-I can maintain the stability of the scalar potential all the way up to the Planck scale if $m_{h_{\rm f}}$ is larger than half the observed Higgs boson mass. Since the parameter space is severely curtailed, especially for the high cutoff scale, the signal rates in the multi-photon states of new Higgs bosons at the LHC are well predicted. We suggest the processes of $4γ+VV'$ ($V^{(\prime)}=Z, W^\pm$) as the golden discovery channels for the model since they enjoy an almost background-free environment and substantial selection efficiencies for four photons.
description: 20 pages with 4 figures
Structure–Activity Relationships and Kinetic Studies of Peptidic Antagonists of CBX Chromodomains
Creators: name: Pearce, Kenneth H.
name: Frye, Stephen V.
name: Cheng, Nancy
name: Norris-Drouin, Jacqueline L.
name: Stuckey, Jacob I.
name: Simpson, Catherine
name: Dickson, Bradley M.
name: Pasca, Ryan
name: Cholensky, Stephanie H.
name: James, Lindsey I.
name: Lee, Junghyun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: To better understand the contribution of methyl-lysine (Kme) binding proteins to various disease states, we recently developed and reported the discovery of 1 (UNC3866), a chemical probe that targets two families of Kme binding proteins, CBX and CDY chromodomains, with selectivity for CBX4 and -7. The discovery of 1 was enabled in part by the use of molecular dynamics simulations performed with CBX7 and its endogenous substrate. Herein, we describe the design, synthesis and structure-activity relationship studies that led to the development of 1 and provide support for our model of CBX7-ligand recognition by examining the binding kinetics of our antagonists with CBX7 as determined by surface-plasmon resonance.
Additional file 2 of Population genetic analyses inferred a limited genetic diversity across the pvama-1 DI domain among Plasmodium vivax isolates from Khyber Pakhtunkhwa regions of Pakistan
Creators: name: Ullah, Ibrar
name: Afridi, Sahib Gul
name: Israr, Muhammad
name: Khan, Hizbullah
name: Shams, Sulaiman
name: Zaib, Komal
name: Le, Huong Giang
name: Kang, Jung-Mi
name: Na, Byoung-Kuk
name: Khan, Asifullah
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Table S1. The haplotypes identified in pvama-1 DI region of KP, Pakistan P. vivax isolates.
First discoveries of z~6 quasars with the Kilo Degree Survey and VISTA Kilo-Degree Infrared Galaxy survey
Creators: name: Venemans, B. P.
name: Kleijn, G. A. Verdoes
name: Mwebaze, J.
name: Valentijn, E. A.
name: Bañados, E.
name: Decarli, R.
name: de Jong, J. T. A.
name: Findlay, J. R.
name: Kuijken, K. H.
name: La Barbera, F.
name: McFarland, J. P.
name: McMahon, R. G.
name: Napolitano, N.
name: Sikkema, G.
name: Sutherland, W. J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present the results of our first year of quasar search in the on-going ESO public Kilo Degree Survey (KiDS) and VISTA Kilo-Degree Infrared Galaxy (VIKING) surveys. These surveys are among the deeper wide-field surveys that can be used to uncovered large numbers of z~6 quasars. This allows us to probe a more common population of z~6 quasars that is fainter than the well-studied quasars from the main Sloan Digital Sky Survey. From this first set of combined survey catalogues covering ~250 deg^2 we selected point sources down to Z_AB=22 that had a very red i-Z (i-Z>2.2) colour. After follow-up imaging and spectroscopy, we discovered four new quasars in the redshift range 5.8
description: 9 pages, 4 figures. Published in Monthly Notices of the Royal Astronomical Society: MNRAS 453, 2259-2266 (2015)
title: ABRA – Fallvorstellung einer seltenen zerebralen Vaskulitis
Creators: name: Riechers, Elke
name: Barrantes-Freer, Alonso
name: Götz, Friedrich
name: Hirsch, Stefanie
name: Schmidt, Reinhold E.
name: Witte, Torsten
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Vorgeschichte: 8/2015 notfallmäßige Aufnahme eines 76-jährigen Patienten wegen erstmals aufgetretenen generalisierten epileptischen Anfalls. Nach Angaben der Ehefrau war es Wochen zuvor bereits zu einer Absence gekommen, ohne dass ein Arzt konsultiert wurde. Während des stationären[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
title: Drei Fälle von Immuncheckpoint-Inhibitor assoziierter Autoimmunität
Creators: name: Derer, Johannes
name: Berghofen, Andrea
name: Krämer, Bernhard K.
name: Löffler, Christian
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Immuncheckpoint-Inhibitoren sind ein fester Bestandteil in der Therapie vieler maligner Erkrankungen. Durch Inhibition antiinflammatorischer, apoptotischer Signalwege wird die Immunantwort gegen maligne Zellen verstärkt. Mit zunehmender klinischer Anwendung geht auch eine steigende [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Structure-Based Design of 3-(4-Aryl-1 H -1,2,3-triazol-1-yl)-Biphenyl Derivatives as P2Y 14 Receptor Antagonists
Creators: name: Trujillo, Kevin
name: Mtchedlidze, Giorgi
name: Junker, Anna
name: Uliassi, Elisa
name: Brown, Kyle A.
name: Birdwell, Leah
name: Harden, T. Kendall
name: Martiriggiano, Chiara
name: Ciancetta, Antonella
name: Kiselev, Evgeny
name: Balasubramanian, Ramachandran
name: Jacobson, Kenneth A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: UDP and UDP-glucose activate the P2Y14 receptor (P2Y14R) to modulate processes related to inflammation, diabetes, and asthma. A computational pipeline suggested alternatives to naphthalene of a previously reported P2Y14R antagonist (3, PPTN) using docking and molecular dynamics simulations on a hP2Y14R homology model based on P2Y12R structures. By reevaluating the binding of 3 to P2Y14R computationally, two alternatives, i.e., alkynyl and triazolyl derivatives, were identified. Improved synthesis of fluorescent antagonist 4 enabled affinity quantification (IC50s, nM) using flow cytometry of P2Y14R-expressing CHO cells. p-F3C-phenyl-triazole 65 (32) was more potent than a corresponding alkyne 11. Thus, additional triazolyl derivatives were prepared, as guided by docking simulations, with nonpolar aryl substituents favored. Although triazoles were less potent than 3 (6), simpler synthesis facilitated further structural optimization. Additionally, relative P2Y14R affinities agreed with predicted binding of a...
GaMPEN: A Machine Learning Framework for Estimating Bayesian Posteriors of Galaxy Morphological Parameters
Creators: name: Ghosh, Aritra
name: Urry, C. Megan
name: Rau, Amrit
name: Perreault-Levasseur, Laurence
name: Cranmer, Miles
name: Schawinski, Kevin
name: Stark, Dominic
name: Tian, Chuan
name: Ofman, Ryan
name: Ananna, Tonima Tasnim
name: Auge, Connor
name: Cappelluti, Nico
name: Sanders, David B.
name: Treister, Ezequiel
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: We introduce a novel machine learning framework for estimating the Bayesian posteriors of morphological parameters for arbitrarily large numbers of galaxies. The Galaxy Morphology Posterior Estimation Network (GaMPEN) estimates values and uncertainties for a galaxy's bulge-to-total light ratio ($L_B/L_T$), effective radius ($R_e$), and flux ($F$). To estimate posteriors, GaMPEN uses the Monte Carlo Dropout technique and incorporates the full covariance matrix between the output parameters in its loss function. GaMPEN also uses a Spatial Transformer Network (STN) to automatically crop input galaxy frames to an optimal size before determining their morphology. This will allow it to be applied to new data without prior knowledge of galaxy size. Training and testing GaMPEN on galaxies simulated to match $z < 0.25$ galaxies in Hyper Suprime-Cam Wide $g$-band images, we demonstrate that GaMPEN achieves typical errors of $0.1$ in $L_B/L_T$, $0.17$ arcsec ($\sim 7\%$) in $R_e$, and $6.3\times10^4$ nJy ($\sim 1\%$) in $F$. GaMPEN's predicted uncertainties are well-calibrated and accurate ($<5\%$ deviation) -- for regions of the parameter space with high residuals, GaMPEN correctly predicts correspondingly large uncertainties. We also demonstrate that we can apply categorical labels (i.e., classifications such as "highly bulge-dominated") to predictions in regions with high residuals and verify that those labels are $\gtrsim 97\%$ accurate. To the best of our knowledge, GaMPEN is the first machine learning framework for determining joint posterior distributions of multiple morphological parameters and is also the first application of an STN to optical imaging in astronomy.
description: Accepted for publication in The Astrophysical Journal. We welcome comments and constructive criticism. Digital assets will be available at http://gampen.ghosharitra.com
Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid Receptor
Creators: name: Zou, Rodger
name: Zheng, Zhong
name: Katritch, Vsevolod
name: Stevens, Raymond C.
name: Huang, Xi-Ping
name: Zaidi, Saheem A.
name: Mangano, Thomas J.
name: Chen, Xin
name: Roth, Bryan L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: The ongoing epidemics of opioid overdose raises an urgent need for effective antiaddiction therapies and addiction-free painkillers. The κ-opioid receptor (KOR) has emerged as a promising target for both indications, raising demand for new chemotypes of KOR antagonists as well as G-protein-biased agonists. We employed the crystal structure of the KOR-JDTic complex and ligand-optimized structural templates to perform virtual screening of available compound libraries for new KOR ligands. The prospective virtual screening campaign yielded a high 32% hit rate, identifying novel fragment-like and lead-like chemotypes of KOR ligands. A round of optimization resulted in 11 new submicromolar KOR binders (best Ki = 90 nM). Functional assessment confirmed at least two compounds as potent KOR antagonists, while compound 81 was identified as a potent Gi biased agonist for KOR with minimal β-arrestin recruitment. These results support virtual screening as an effective tool for discovery of new lead chemotypes with therapeutically relevant functional profiles.
title: Fieber bei einem hepatisch metastasiertem malignen Melanom – oder doch eine Autoimmunerkrankung
Creators: name: Seidel, Carolin
name: Oelzner, Peter
name: Theis, Bernhard
name: Renz, Diane
name: Schmidt, Carsten
name: Freesmeyer, Martin
name: Wolf, Gunter
name: Pfeil, Alexander
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Vorgeschichte: Die Vorstellung der Patientin erfolgte mit Fieber und Gewichtsverlust unklarer Genese. Bei abdominellen Schmerzen, Übelkeit und Erbrechen wurde in einem auswärtigen Krankenhaus unter der Diagnose einer Choledocholithiasis mit Cholangitis (Zustand nach Cholezytektomie) eine ERCP[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Additional file 3 of Population genetic analyses inferred a limited genetic diversity across the pvama-1 DI domain among Plasmodium vivax isolates from Khyber Pakhtunkhwa regions of Pakistan
Creators: name: Ullah, Ibrar
name: Afridi, Sahib Gul
name: Israr, Muhammad
name: Khan, Hizbullah
name: Shams, Sulaiman
name: Zaib, Komal
name: Le, Huong Giang
name: Kang, Jung-Mi
name: Na, Byoung-Kuk
name: Khan, Asifullah
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3: Fig S2. Linkage disequilibrium (LD) pattern of pvama-1 DI sequences of P. vivax isolates from KP, Pakistan. The LD index (R2) (Y-axis) plotted against nucleotide distance (X-axis) using a two tailed Fisher’s exact test.
Ice features of low-luminosity protostars in near-infrared spectra of AKARI/IRC
Creators: name: Kim, Jaeyeong
name: Lee, Jeong-Eun
name: Jeong, Woong-Seob
name: Kim, Il-Seok
name: Aikawa, Yuri
name: Noble, Jeniffer A.
name: Choi, Minho
name: Lee, Ho-Gyu
name: Dunham, Michael M.
name: Kim, Chul-Hwan
name: Koo, Bon-Chul
Publisher: name: arXiv
Year: 2022
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present near-infrared spectra of three low-luminosity protostars and one background star in the Perseus molecular cloud, acquired using the Infrared Camera (IRC) onboard the \textit{AKARI} space telescope. For the comparison with different star-forming environments, we also present spectra of the massive protostar AFGL 7009S, where the protostellar envelope is heated significantly, and the low-mass protostar RNO 91, which is suspected to be undergoing an episodic burst. We detected ice absorption features of \ch{H2O}, \ch{CO2}, and \ch{CO} at all spectra around the wavelengths of 3.05, 4.27, and 4.67 $μ$m, respectively. At least two low-luminosity protostars, we also detected the \ch{XCN} ice feature at 4.62 $μ$m. The presence of the crystalline \ch{H2O} ice and \ch{XCN} ice components indicates that the low-luminosity protostars experienced a hot phase via accretion bursts during the past mass accretion process. We compared the ice abundances of low-luminosity protostars with those of the embedded low-mass protostars and the dense molecular clouds and cores, suggesting that their ice abundances reflect the strength of prior bursts and the timescale after the last burst.
description: 34 pages, 9 figures
Femtosecond laser pulse train interaction with dielectric materials
Creators: name: Caulier, O. Dematteo
name: Mishchik, K.
name: Chimier, B.
name: Skupin, S.
name: Bourgeade, A.
name: Léger, C. Javaux
name: Kling, R.
name: Hönninger, C.
name: Lopez, J.
name: Tikhonchuk, V.
name: Duchateau, G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We investigate the interaction of trains of femtosecond microjoule laser pulses with dielectric materials by means of a multi-scale model. Our theoretical predictions are directly confronted with experimental observations in soda-lime glass. We show that due to the low heat conductivity, a significant fraction of the laser energy can be accumulated in the absorption region. Depending on the pulse repetition rate, the material can be heated to high temperatures even though the single pulse energy is too low to induce a significant material modification. Regions heated above the glass transition temperature in our simulations correspond very well to zones of permanent material modifications observed in the experiments.
description: 4 pages, 4 figures
Urea Derivatives of 2-Aryl-benzothiazol-5-amines: A New Class of Potential Drugs for Human African Trypanosomiasis
Creators: name: Buckner, Frederick S.
name: Herbst, Zackary M.
name: Hulverson, Matthew A.
name: Ranade, Ranae M.
name: Tidwell, Richard R.
name: Gelb, Michael H.
name: Patrick, Donald A.
name: Gillespie, J. Robert
name: McQueen, Joshua
name: Creason, Sharon A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: A previous publication from this lab (Patrick, et al. Bioorg. Med. Chem. 2016, 24 , 2451 - 2465 ) explored the antitrypanosomal activities of novel derivatives of 2-(2-benzamido)ethyl-4-phenylthiazole (1), which had been identified as a hit against Trypanosoma brucei, the causative agent of human African trypanosomiasis. While a number of these compounds, particularly the urea analogues, were quite potent, these molecules as a whole exhibited poor metabolic stability. The present work describes the synthesis of 65 new analogues arising from medicinal chemistry optimization at different sites on the molecule. The most promising compounds were the urea derivatives of 2-aryl-benzothiazol-5-amines. One such analogue, (S)-2-(3,4-difluorophenyl)-5-(3-fluoro-N-pyrrolidylamido)benzothiazole (57) was chosen for in vivo efficacy studies based upon in vitro activity, metabolic stability, and brain penetration. This compound attained 5/5 cures in murine models of both early and late stage human African trypanosomiasis, representing a new lead for the development of drugs to combat this neglected disease.
Bridging Optical and Far-Infrared Emission-Line Diagrams of Galaxies from Local to the Epoch of Reionization: Characteristic High [O III] 88 $\mathrm{μm}$/SFR at $z > 6$
Creators: name: Sugahara, Yuma
name: Inoue, Akio K.
name: Fudamoto, Yoshinobu
name: Hashimoto, Takuya
name: Harikane, Yuichi
name: Yamanaka, Satoshi
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present photoionization modeling of galaxy populations at $z\sim0$, $2$, and $> 6$ to bridge optical and far-infrared (FIR) emission-line diagrams. We collect galaxies with measurements of optical and/or FIR ([O III] 88 $\mathrm{μm}$ and [C II] 158 $\mathrm{μm}$) emission line fluxes and plot them on the [O III]$\lambda5007/\mathrm{Hβ}$--[N II]$\lambda6585/\mathrm{Hα}$ (BPT) and L([O III]88)/SFR--L([C II]158)/SFR diagrams, where SFR is the star-formation rate and L([O III]88) and L([C II]158) are the FIR line luminosities. We aim to explain the galaxy distributions on the two diagrams with photoionization models that employ three nebular parameters: the ionization parameter $U$, hydrogen density $n_\text{H}$, and gaseous metallicity $Z_\text{gas}$. Our models successfully reproduce the nebular parameters of local galaxies, and then predict the distributions of the $z\sim0$, $2$, and $> 6$ galaxies on the diagrams. The predicted distributions illustrate the redshift evolution on all the diagrams; e.g., [O III]$/\mathrm{Hβ}$ and [O III]88/[C II]158 ratios continuously decrease from $z > 6$ to $0$. Specifically, the $z > 6$ galaxies exhibit $\sim\!0.5$ dex higher $U$ than low-redshift galaxies at a given $Z_\text{gas}$ and show predicted flat distributions on the BPT diagram at $\log{\mathrm{[O III]/Hβ}} = 0.5$-$0.8$. We find that some of the $z > 6$ galaxies exhibit high L([O III]88)/SFR ratios. To explain these high ratios, our photoionization models require a low stellar-to-gaseous metallicity ratio or bursty/increasing star-formation history at $z > 6$. The James Webb Space Telescope will test the predictions and scenarios for the $z > 6$ galaxies proposed by our photoionization modeling.
description: 18 pages + 5 appendix pages, 11 figures, 1 tables. accepted for publication in ApJ
Multiwavelength Vertical Structure in the AU Mic Debris Disk: Characterizing the Collisional Cascade
Creators: name: Vizgan, David
name: Hughes, A. Meredith
name: Carter, Evan S.
name: Flaherty, Kevin M.
name: Pan, Margaret
name: Chiang, Eugene
name: Schlichting, Hilke
name: Wilner, David J.
name: Andrews, Sean M.
name: Carpenter, John M.
name: Moór, Atilla
name: MacGregor, Meredith A.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Debris disks are scaled-up analogs of the Kuiper Belt in which dust is generated by collisions between planetesimals. In the "collisional cascade" model of debris disks, dust lost to radiation pressure and winds is constantly replenished by grinding collisions between planetesimals. The model assumes that collisions are destructive and involve large velocities; this assumption has not been tested beyond our Solar System. We present 0"25 ($\approx$2.4 au) resolution observations of the $λ$ = 450 $μ$m dust continuum emission from the debris disk around the nearby M dwarf AU Microscopii with the Atacama Large Millimeter/submillimeter Array. We use parametric models to describe the disk structure, and an MCMC algorithm to explore the posterior distributions of the model parameters; we fit the structure of the disk to both our data and archival $λ= 1.3$ mm data (Daley et al. 2019), from which we obtain two aspect ratio measurements at 1.3 mm ($h_{1300}$ = 0.025$^{+0.008}_{-0.002}$) and at 450 $μ$m ($h_{450}$ = 0.019$^{+0.006}_{-0.001}$), as well as the grain size distribution index $q =$ 3.03 $\pm$ 0.02. Contextualizing our aspect ratio measurements within the modeling framework laid out in Pan & Schlichting (2012), we derive a power law index of velocity dispersion as a function of grain size $p = 0.28 \pm 0.06$ for the AU Mic debris disk. This result implies that smaller bodies are more easily disrupted than larger bodies by collisions, which is inconsistent with the strength regime usually assumed for such small bodies. Possible explanations for this discrepancy are discussed.
description: 17 pages, 6 figures, 3 tables. Accepted for publication in ApJ
Single-cell functional analysis of parathyroid adenomas reveals distinct classes of calcium sensing behaviour in primary hyperparathyroidism
Creators: name: Sosa, Julie A.
name: Shi, Yuhong
name: Allbritton, Nancy L.
name: Hogue, Joyce A.
name: Koh, James
name: Wang, Yuli
name: Olson, John A.
name: Disalvo, Matthew
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: AbstractPrimary hyperparathyroidism (PHPT) is a common endocrine neoplastic disorder caused by a failure of calcium sensing secondary to tumour development in one or more of the parathyroid glands. Parathyroid adenomas are comprised of distinct cellular subpopulations of variable clonal status that exhibit differing degrees of calcium responsiveness. To gain a clearer understanding of the relationship among cellular identity, tumour composition and clinical biochemistry in PHPT, we developed a novel single cell platform for quantitative evaluation of calcium sensing behaviour in freshly resected human parathyroid tumour cells. Live‐cell intracellular calcium flux was visualized through Fluo‐4‐AM epifluorescence, followed by in situ immunofluorescence detection of the calcium sensing receptor (CASR), a central component in the extracellular calcium signalling pathway. The reactivity of individual parathyroid tumour cells to extracellular calcium stimulus was highly variable, with discrete kinetic response patterns observed both between and among parathyroid tumour samples. CASR abundance was not an obligate determinant of calcium responsiveness. Calcium EC50 values from a series of parathyroid adenomas revealed that the tumours segregated into two distinct categories. One group manifested a mean EC50 of 2.40 mM (95% CI: 2.37–2.41), closely aligned to the established normal range. The second group was less responsive to calcium stimulus, with a mean EC50 of 3.61 mM (95% CI: 3.45–3.95). This binary distribution indicates the existence of a previously unappreciated biochemical sub‐classification of PHPT tumours, possibly reflecting distinct etiological mechanisms. Recognition of quantitative differences in calcium sensing could have important implications for the clinical management of PHPT.
Additional file 4 of Population genetic analyses inferred a limited genetic diversity across the pvama-1 DI domain among Plasmodium vivax isolates from Khyber Pakhtunkhwa regions of Pakistan
Creators: name: Ullah, Ibrar
name: Afridi, Sahib Gul
name: Israr, Muhammad
name: Khan, Hizbullah
name: Shams, Sulaiman
name: Zaib, Komal
name: Le, Huong Giang
name: Kang, Jung-Mi
name: Na, Byoung-Kuk
name: Khan, Asifullah
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 4: Fig S3. Pearson correlation plot of KP and global pvama-1 samples based on pairwise Fst values. The plot shows clustering and correlation between the groups in hierarchical order. The dark brackets and large sizes depict the minimum genetic distinction and high correlation.
Additional file 5 of Population genetic analyses inferred a limited genetic diversity across the pvama-1 DI domain among Plasmodium vivax isolates from Khyber Pakhtunkhwa regions of Pakistan
Creators: name: Ullah, Ibrar
name: Afridi, Sahib Gul
name: Israr, Muhammad
name: Khan, Hizbullah
name: Shams, Sulaiman
name: Zaib, Komal
name: Le, Huong Giang
name: Kang, Jung-Mi
name: Na, Byoung-Kuk
name: Khan, Asifullah
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 5: Fig S4. The principle component analysis (PCA) of pvama-1 DI sequences. Different colors depict different populations groups. This include KP Pakistan (as a single group) and worldwide samples.
How Sedna and family were captured in a close encounter with a solar sibling
Creators: name: Jilkova, Lucie
name: Zwart, Simon Portegies
name: Pijloo, Tjibaria
name: Hammer, Michael
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The discovery of 2012VP113 initiated the debate on the origin of the Sedna family of planetesimals in orbit around the Sun. Sednitos roam the outer regions of the Solar System between the Egeworth--Kuiper belt and the Oort cloud, in extraordinary wide (a>150au) orbits with a large perihelion distance of q>30au compared to the Earth's (a=1au and eccentricity e=(1-q/a) ~ 0.0167 or q=1au). This population is composed of a dozen objects, which we consider a family because they have similar perihelion distance and inclination with respect to the ecliptic i=10--30deg. They also have similar argument of perihelion omega=340+/-55deg. There is no ready explanation for their origin. Here we show that these orbital parameters are typical for a captured population from the planetesimal disk of another star.Assuming the orbital elements of Sednitos have not changed since they acquired their orbits, we reconstruct the encounter that led to their capture. We conclude that they might have been captured in a near miss with a 1.8MSun star that impacted the Sun at ~340au at an inclination with respect to the ecliptic of 17--34deg with a relative velocity at infinity of ~4.3km/s. We predict that the Sednitos-region is populated by 930 planetesimals and the inner Oort cloud acquired ~440 planetesimals through the same encounter.
description: Accepted for publication in MNRAS; 7 pages, 2 figures, 1 table; extended discussion, corrected typos and references