cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Pyrimidine Ribonucleotides with Enhanced Selectivity as P2Y 6 Receptor Agonists: Novel 4-Alkyloxyimino, (S)-Methanocarba, and 5′-Triphosphate γ-Ester Modifications †
Creators: name: Harden, T. Kendall
name: Berk, Barkin
name: Jacobson, Kenneth A.
name: Balasubramanian, Ramachandran
name: Tosh, Dilip K.
name: Maruoka, Hiroshi
name: Costanzi, Stefano
name: Burianek, Lauren E.
name: Barrett, Matthew O.
name: Melman, Artem
name: Ko, Hyojin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The P2Y6 receptor is a cytoprotective G protein-coupled receptor (GPCR) activated by UDP (EC50, 0.30 μM). We compared and combined modifications to enhance P2Y6 receptor agonist selectivity, including ribose ring constraint, 5-iodo and 4-alkyloxyimino modifications, and phosphate modifications such as α,β-methylene and extension of the terminal phosphate group into γ-esters of UTP analogues. The conformationally constrained (S)-methanocarba UDP is a full agonist (EC50 0.042 μM). 4-Methoxyimino modification of pyrimidine enhanced P2Y6, preserved P2Y2 and P2Y4, and abolished P2Y14 receptor potency, in the appropriate nucleotide. N4-Benzyloxy-CDP (15, MRS2964) and N4-methoxy-Cp3U (23, MRS2957) were potent, selective P2Y6 receptor agonists (EC50 0.026 μM and 0.012 μM, respectively). A hydrophobic binding region near the nucleobase was explored with receptor modeling and docking. UTP-γ-aryl and cycloalkyl phosphoesters displayed only intermediate P2Y6 receptor potency, but had enhanced stability in acid and cell membranes. UTP-glucose was inactive, but its (S)-methanocarba analogue and N4-methoxy-cytidine 5′-triphospho-γ-[1]glucose were active (EC50 of 2.47 μM and 0.18 μM, respectively). Thus, the potency, selectivity, and stability of pyrimidine nucleotides as P2Y6 receptor agonists may be enhanced by modest structural changes.
Additional file 3 of Characteristics and recovery methods of studies falsely excluded during literature screening—a systematic review
Creators: name: Affengruber, Lisa
name: Dobrescu, Andreea
name: Persad, Emma
name: Klerings, Irma
name: Wagner, Gernot
name: Sommer, Isolde
name: Gartlehner, Gerald
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 3. Search strategy for similar articles searches in PubMed, Google Scholar and Scopus.
Synthesis and Anticonvulsant Activities of ( R )- N -(4′-Substituted)benzyl 2-Acetamido-3-methoxypropionamides
Creators: name: Kohn, Harold
name: Park, Ki Duk
name: Stables, James P.
name: Salomé, Christophe
name: DeMarco, Erica
name: Morieux, Pierre
name: Salomé-Grosjean, Elise
name: Swendiman, Robert
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The structure-activity relationship (SAR) for the N-benzyl group in the clinical antiepileptic agent (R)-lacosamide ((R)-N-benzyl 2-acetamido-3-methoxypropionamide, (R)-3) has been explored. Forty-three compounds were prepared and then evaluated at the National Institute of Neurological Disorders and Stroke Anticonvulsant Screening Program for seizure protection in the maximal electroshock (MES) and subcutaneous Metrazol models. Comparing activities for two series of substituted aryl regioisomers (2′, 3′, 4′) showed that 4′-modified derivatives had the highest activity. Significantly, structural latitude existed at the 4′-site. The SAR indicated that non-bulky 4′-substituted (R)-3 derivatives exhibited superb activity, independent of their electronic properties. Activities in the MES test of several compounds were either comparable with or exceeded that of (R)-3, and surpassed the activities observed for the traditional antiepileptic agents phenytoin, phenobarbital, and valproate.
title: Modified Dixon fat-water imaging for detecting intravertebral fracture line : usefulness for differentiation between in the benign and malignant vertebral compression fractures
Creators: name: Kim, Boyeon
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Trauma
subject: Metastases
subject: Artifacts
subject: Physics
subject: Imaging sequences
subject: MR
subject: Musculoskeletal spine

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: • Fracture line, that is, bandlike low signal intensity on T1- and T2-weighted images provided excellent distinction between acute osteoporotic VCFs and pathologic VCFs of the spines (5). Presence of fracture line was suggestive of acute...
Interplay between the coherent and incoherent transport in quantum Hall bilayers
Creators: name: Zhang, Ding
name: Huang, Xuting
name: Dietsche, Werner
name: Hauser, Maik
name: von Klitzing, Klaus
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We systematically study the coherent transport (Josephson tunneling and counterflow current) and its breakdown which leads to incoherent charge flow in in the excitonic BCS condensate formed in GaAs bilayers at $ν_{tot}=1/2+1/2$. The Josephson currents in samples with three different interlayer distances vary by four orders of magnitude. In contrast, the breakdown thresholds for the $ν_{tot}=1$ quantum Hall state are comparable. Furthermore, Coulomb drag in a Corbino ring reveals that the coherent counterflow current coexists with the dissipative charge transport.
title: Economic adjustment programmes and the export sector of Guyana 1962-83.
Creators: name: Gajadar, B.
Publisher: name: University of Liverpool Repository
Year: 2023

description: Efforts to diversify the colonial economy in Guyana after 1966 were unsuccessful. With the oil shock of 1973, and falling commodity prices after 1975, the economy became unstable. This instability is expressed in large balance of payments deficits, deficit financing, lower export levels and a rise in inflation. Policies to restore economic stability involved the implementation of stabilisation and structural adjustment programmes between 1977-84, with the participation of the IMF and World Bank. The objective is to investigate factors affecting economic stabilisation of both domestic prices and the balance of payments Emphasis is placed on the study of aggregate supply, which examines . the behaviour of exports and inflation. These two factors are linked to the balance of payments. The assumption is made that exports are influenced by supply variables, such as domestic output, international prices, labour costs and movements in the exchange rate. The analysis of exports reveals that their response is delayed and inelastic to changes in price and other factors. This is consistent with estimates for primary commodity exports from small low income countries. The partial adjustment/adaptive expectations model provides satisfactory evidence for the behaviour of commodity exports, except in the case of sugar. For sugar an export supply function is estimated. The analysis of inflation reveals that external influences are more dominant than domestic factors in the inflationary process. The results suggest that the supply response for all commodities is slow in the short run, but may be faster in the long run. This implies that the implementation of appropriate stabilisation policies may be able to improve the deficit in the balance of payments, but that lags may exist in the adjustment process. The constraining factors would be increased labour costs in the export sector and higher import prices for industrial inputs.
Subnational Inequalities in Mortality: Developments and applications in decomposition methods
Creators: name: Su, Wen
Publisher: name: The Australian National University
Year: 2024

description: Mortality inequalities have become a public health priority within society as countries are experiencing increasing disparities, as shown by gradients of life expectancy and life span variation between different subpopulations stratified by socioeconomic status. Life expectancy and life span variation measure the average length of life and the variability in age-at-death distribution for the subpopulation, respectively. These inequalities should be a public health priority since "[Mortality inequality] ...is the most fundamental of all inequalities; every other type of inequality is conditional upon being alive." (van Raalte et al. 2018). A large body of literature has been dedicated to exploring, investigating, and evaluating mortality inequalities at the national level. However, explorations on the heterogeneous mortality levels of the subpopulations under the national "umbrella", i.e. the mortality at the national level, are needed. More importantly, these different mortality experiences among subpopulations aggregate towards the mortality trend we observe at the national level. The national-level mortality is merely a manifestation of different mortality schedules belonging to different subpopulations at the subnational level. The exploration of the subnational-national link of mortality would guide approaches that improve life expectancies and life span variations for more disadvantaged populations and for future improvements to mortality at the national level. This dissertation aims to explore and quantify the relationship between the mortality changes at the national level and the mortality experiences of its subpopulations. The research questions include how do mortality rates of subpopulations influence mortality at the national level? And how sensitive is mortality at the national level to mortality changes at the subnational level? In order to answer these research questions, this dissertation proposes novel decomposition methods and applications in mathematical demography. The theoretical contribution of this dissertation is to further the understanding of the mathematical link between micro and macro levels of mortality, which is not sufficiently addressed in the current demographic literature.
CBM-Of-TRaCE: An Ontology-Driven Framework for the Improvement of Business Service Traceability, Consistency Management and Reusability
Creators: name: Erfanian, Aida
name: Darav, Nima Karimpour
Publisher: name: arXiv
Year: 2014
Subjects: subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences
subject: D.2; K.6.3
subject: 68Q55,

description: In this paper, we represent CBM-Of-TRaCE which is an ontological framework that integrates two aspects of business components: conceptual and methodology. In the development of our framework we have taken IBM Actionable Business Approach (ABA) in to consideration. We evaluate our framework through some aspects such as support and facilitation for a business from five different aspects: service-orientation, business process, management integration, reusability improvement, consistency rules, and traceability. As well, we demonstrate the compatibility of our CBM-Of-TRaCE with ABA four phases.
description: 10 pages, 3 figures, International Journal of Soft Computing and Software Engineering, no. 7.7., vol. 2, 2012
Synthesis and Antiprotozoal Activity of Cationic 1,4-Diphenyl-1 H -1,2,3-triazoles
Creators: name: Brun, Reto
name: Ghebru, Maedot
name: Werbovetz, Karl A.
name: Bakunov, Stanislav A.
name: Tidwell, Richard R.
name: Bakunova, Svetlana M.
name: Wenzler, Tanja
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Novel dicationic triazoles 1–60 were synthesized by the Pinner method from the corresponding dinitriles, prepared via the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The type and the placement of cationic moieties as well as the nature of aromatic substituents influenced in vitro antiprotozoal activities of compounds 1–60 against Trypanosoma brucei rhodesiense, Plasmodium falciparum, and Leishmania donovani and their cytotoxicity for mammalian cells. Eight congeners displayed antitrypanosomal IC50 values below 10 nM. Thirty-nine dications were more potent against P. falciparum than pentamidine (IC50 = 58 nM) and eight analogues were more active than artemisinin (IC50 = 6 nM). Diimidazoline 60 exhibited antiplasmodial IC50 value of 0.6 nM. Seven congeners administered at 4 × 5 mg/kg by the intraperitoneal route cured at least three out of four animals in the acute mouse model of African trypanosomiasis. At 4 × 1 mg/kg, diamidine 46 displayed better antitrypanosomal efficacy than melarsoprol, curing all infected mice.
Additional file 1 of Feasibility of a protocol for deprescribing antihypertensive medication in older patients in Dutch general practices
Creators: name: Hassan, Dimokrat
name: Versmissen, Jorie
name: Hek, Karin
name: van Dijk, Liset
name: van den Bemt, Patricia M. L. A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Additional file 1.
The Structure−Activity Relationship of the 3-Oxy Site in the Anticonvulsant ( R )- N -Benzyl 2-Acetamido-3-methoxypropionamide
Creators: name: Stables, James P.
name: Park, Ki Duk
name: Morieux, Pierre
name: Salomé, Christophe
name: Kohn, Harold
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Lacosamide ((R)-N-benzyl 2-acetamido-3-methoxypropionamide, (R)-1) is a low molecular weight anticonvulsant recently introduced in the United States and Europe for adjuvant treatment of partial-onset seizures in adults. In this study, we define the structure-activity relationship (SAR) for the compound's 3-oxy site. Placement of small non-polar, non-bulky substituents at the 3-oxy site provided compounds with pronounced seizure protection in the maximal electroshock (MES) seizure test with activities similar to (R)-1. The anticonvulsant activity loss that accompanied introduction of larger moieties at the 3-oxy site in (R)-1 was offset, in part, by including unsaturated groups at this position. Our findings were similar to a recently reported SAR study of the 4′-benzylamide site in (R)-1 (J. Med. Chem.2010, 53, 1288–1305). Together, these results indicate that both the 3-oxy and 4′-benzylamide positions in (R)-1 can accommodate non-bulky, hydrophobic groups and still retain pronounced anticonvulsant activities in rodents in the MES seizure model.
title: Don’t forget the role of MRI and CT to diagnose Rhinocerebral Mucormycosis and its vascular complications
Creators: name: Mazzai, Linda
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Infection
subject: Haemorrhage
subject: Diagnostic procedure
subject: MR
subject: CT
subject: Neuroradiology brain
subject: Head and neck
subject: Ischaemia / Infarction

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To describe the role of CT and MRI to diagnose Rhinocerebral Mucormycosis (RCM) To describe the imaging key findings of RCM, and especially its life-threatening cerebrovascular...
title: Niccolò Degli Agostini traduttore in “verso vulgar” delle Metamorfosi ovidiane
title: un percorso diacronico tra riscritture dei miti e invenzioni allegoriche
titleType: AlternativeTitle
Creators: name: Celentano, Sandra
Publisher: name: Universita degli studi di Salerno
Year: 2014
Subjects: subject: L-FIL-LET/10 LETTERATURA ITALIANA
subject: Degli Agostini, Niccolò
subject: Ovidio - Metamorfosi

description: 2013-2014
description: The doctorate’s research primarily focuses on the vernacular translation of Ovid's Metamorphoses, designed by Nicolò degli Agostini and published in 1522 in Venice: Tutti li libri de Ovidio Metamorphoseos tradutti dal litteral in verso vulgar con le sue Allegorie in prosa. Probably the work of Agostini is a rewrite of Giovanni Bonsignori’s Ovidio Metamorphoseos vulgare, wrote between 1375 and 1377: i due to his knowledge of Latin, Agostini would have made a vulgar paraphrase of the previous text, departing and / or by manipulating the verses Ovidian. From a detailed comparison with the critical edition of Bonsignori’s translation it was possible to identify not only what and how of the Agostini has kept in mind, but also how and in what manner the same Bonsignori has approached the comment of Metamorphosis made by Giovanni del Virgilio, which in turn was remade to Arnolfo d'Orléans, precursor, since 1175, the history and fortune of the comments and vernacular translations of Ovid's works. .. [edited by Author]
description: La tesi di dottorato verte essenzialmente sul volgarizzamento delle Metamorfosi ovidiane, realizzato da Niccolò degli Agostini e pubblicato nel 1522 a Venezia: Tutti li libri de Ovidio Metamorphoseos tradutti dal litteral in verso vulgar con le sue Allegorie in prosa. Lo studio dell’opera ha richiesto una complessa metodologia di approccio non solo a livello filologico, ma anche comparatistico e plurilinguistico. Probabilmente l’opera di degli Agostini è una riscrittura dell’Ovidio Metamorphoseos vulgare di Giovanni Bonsignori, realizzato tra il 1375 e il 1377: in difficoltà per la scarsa conoscenza del latino, degli Agostini avrebbe effettuato una parafrasi del precedente testo volgare, discostandosi e / o manipolando i versi ovidiani. Da un puntuale confronto con l’edizione critica della traduzione del Bonsignori è stato possibile individuare non solo quanto e in che modo degli Agostini l’abbia tenuta presente, ma anche quanto e in che modo lo stesso Bonsignori si sia avvicinato al lavoro espositivo delle Metamorfosi compiuto da Giovanni del Virgilio che a sua volta si era rifatto ad Arnolfo d’Orléans, precursore, fin dal 1175, della storia e della fortuna dei commenti e dei volgarizzamenti dell’opera ovidiana. .. [a cura dell'Autore]
Why z > 1 radio-loud galaxies are commonly located in proto-clusters
Creators: name: Hatch, N. A.
name: Wylezalek, D.
name: Kurk, J. D.
name: Stern, D.
name: De Breuck, C.
name: Jarvis, M. J.
name: Galametz, A.
name: Gonzalez, A. H.
name: Hartley, W. G.
name: Mortlock, A.
name: Seymour, N.
name: Stevens, J. A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Distant powerful radio-loud active galactic nuclei (RLAGN) tend to reside in dense environments and are commonly found in proto-clusters at z > 1.3. We examine whether this occurs because RLAGN are hosted by massive galaxies, which preferentially reside in rich environments. We compare the environments of powerful RLAGN at 1.3 < z < 3.2 from the CARLA survey to a sample of radio-quiet galaxies matched in mass and redshift. We find the environments of RLAGN are significantly denser than those of radio-quiet galaxies, implying that not more than 50% of massive galaxies in this epoch can host powerful radio-loud jets. This is not an observational selection effect as we find no evidence to suggest it is easier to observe the radio emission when the galaxy resides in a dense environment. We therefore suggest that the dense Mpc-scale environment fosters the formation of a radio-jet from an AGN. We show that the number density of potential RLAGN host galaxies is consistent with every > 10^14 solar mass cluster having experienced powerful radio-loud feedback of duration ~60 Myr during 1.3 < z < 3.2. This feedback could heat the intracluster medium to the extent of 0.5-1 keV per gas particle, which could limit the amount of gas available for further star formation in the proto-cluster galaxies.
description: Accepted for publication in MNRAS
Antitumor Agents 288: Design, Synthesis, SAR, and Biological Studies of Novel Heteroatom-Incorporated Antofine and Cryptopleurine Analogues as Potent and Selective Antitumor Agents
Creators: name: Morris-Natschke, Susan L.
name: Lai, Chin-Yu
name: Lin, Jau-Chen
name: Lee, Kuo-Hsiung
name: Pan, Shiow-Lin
name: Shi, Qian
name: Yang, Xiaoming
name: Wu, Pei-Chi
name: Chen, Chi-Yuan
name: Teng, Che-Ming
name: Yang, Pan-Chyr
name: Yu, Sung-Liang
name: Wu, Tian-Shung
name: Yang, Shuenn-Chen
name: Bastow, Kenneth F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Novel heteroatom-incorporated antofine and cryptopleurine analogs were designed, synthesized, and tested against a panel of five cancer cell lines. Two new S-13-oxo analogs (11 and 16) exhibited potent cell growth inhibition in vitro (GI50: 9 nM and 20 nM). Interestingly, both compounds displayed improved selectivity among different cancer cell lines, in contrast to the natural products antofine and cryptopleurine. MOAa studies suggested that R-antofine promotes dysregulation of DNA replication during early S phase, while no similar effects were observed for 11 and 15 on corresponding replication initiation complexes. Compound 11 also showed greatly reduced cytotoxicity against normal cells and moderate antitumor activity against HT-29 human colorectal adenocarcinoma xenograft in mice without overt toxicity.
Indium Phosphide Nanowire Arrays for Gas Sensing Applications
Creators: name: Wei, Shiyu
Publisher: name: The Australian National University
Year: 2024

description: Semiconductor chemiresistive gas sensor is one of the most promising technologies for the development of next-generation chemical sensing, with applications ranging from explosive detection and environmental monitoring to industrial safety, healthcare and the Internet of Things (IoTs). Recently, there have been growing efforts in developing room temperature chemiresistive gas sensors with high sensitivity, selectivity, long-term stability, and low power consumption. In this thesis, we develop indium phosphide (InP) nanowire (NW) array based chemiresistive gas sensors and demonstrate that they represent a new and promising platform for achieving high-performance gas sensing for real-world applications. Firstly, by carefully engineering the NW geometry (i.e., diameter and pitch), we demonstrate a NO2 sensor with superior sensitivity (limit of detection 3.1 ppb) at room temperature, with outstanding selectivity and long-term stability. Kinetic analysis and electrical simulation reveal the array geometry correlated sensing mechanism. To minimize the device power consumption, a novel axial p-i-n homojunction self-powered photovoltaic (PV) NO2 NW sensor was further designed through numerical simulation and optimization. The fabricated InP NW array PV sensor achieved 84% sensing response to 1 ppm NO2 with a record limit of detection down to sub-ppb level even under <5% of 1 sun illumination. With such high atmospheric light fidelity, the sensor was integrated onto a commercial microchip interface for dynamic self-powered monitoring of on-field motor vehicle exhaust. Not only for oxidizing gas such as NO2, we have also shown that by applying surface-modification, the InP NW array can also be fabricated into highly sensitive sensors to reducing gases such as acetone. This is critical for the development of breath ketone sensors for diabetes monitoring and diagnostics. This acetone sensor was then integrated into a breath testing apparatus, named Ketowhistle, and proven to be highly effective across an ultrabroad range of acetone concentrations from the simulated breath. Finally, a wearable multipixel InP nanowire array sensor was fabricated on a flexible substrate. A signal decoupling strategy was designed and implemented through careful device fabrication control, surface-functionalisation and different contact metal selection. This approach has led to the demonstration of a multipixel sensor device consisting of four sensing elements with integrated functionality, including NO2 and acetone sensing, as well as simultaneous pulse and body temperature measurements. The thesis work indicates that III-V compound semiconductor nanowire array presents a promising chemical sensing platform for the development of high performance, miniaturized, low power consumption, multiplexing on-chip sensing system for future large-scale implementation of IoT technology.
Analytical solutions of a fractional diffusion-advection equation for solar cosmic-ray transport
Creators: name: Litvinenko, Yuri E.
name: Effenberger, Frederic
Publisher: name: arXiv
Year: 2014
Subjects: subject: Space Physics (physics.space-ph)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Motivated by recent applications of superdiffusive transport models to shock-accelerated particle distributions in the heliosphere, we solve analytically a one-dimensional fractional diffusion-advection equation for the particle density. We derive an exact Fourier transform solution, simplify it in a weak diffusion approximation, and compare the new solution with previously available analytical results and with a semi-numerical solution based on a Fourier series expansion. We apply the results to the problem of describing the transport of energetic particles, accelerated at a traveling heliospheric shock. Our analysis shows that significant errors may result from assuming an infinite initial distance between the shock and the observer. We argue that the shock travel time should be a parameter of a realistic superdiffusive transport model.
description: 5 pages, 2 figures, accepted for publication in The Astrophysical Journal
V745\,Cassiopeia: an interacting young massive binary in a multiple star system
Creators: name: Cakirli, O.
name: Ibanoglu, C.
name: Sipahi, E.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present spectroscopic observations of the massive early type system V745\,Cas, embedded in a multiple star system. The brightest star of the system is the eclipsing binary V745\,Cas with an orbital period of 1.41 days. The radial velocities of both components and light curves obtained by $INTEGRAL$ and $Hipparcos$ missions were analysed. The components of V745\,Cas are shown to be a B0\,V primary with a mass M$_p$=18.31$\pm$0.51 M$_{\odot}$ and radius R$_p$=6.94$\pm$0.07 R$_{\odot}$ and a B(1-2)\,V secondary with a mass M$_s$=10.47$\pm$0.28 M$_{\odot}$ and radius R$_s$=5.35$\pm$0.05 R$_{\odot}$. Our analysis shows that both components fill their corresponding $Roche$ lobes, indicating double contact configuration. Using the UBVJHK magnitudes and interstellar absorption we estimated the mean distance to the system as 1700$\pm$50\,pc. The locations of the component stars in the mass-luminosity, mass-radius, effective temperature-mass and surface gravity-mass are in agreement with those of the main-sequence massive stars. We also obtained $UBV$ photometry of the three visual companions and we estimate that all are B-type stars based upon their de-reddened colours.We suspect that this multiple system is probably a member of the Cas OB4 association in the $Perseus$ arm of the $Galaxy$.
description: 21 pages, 7 figures Accepted by MNRAS
title: CT and MRI of orbital masses: How can radiologist help the surgeon
Creators: name: Alonso  Ordás, Nuria
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Pathology
subject: Neoplasia
subject: Education and training
subject: Technical aspects
subject: Education
subject: Diagnostic procedure
subject: PET-CT
subject: MR
subject: CT
subject: Oncology
subject: Head and neck
subject: Anatomy

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: •Review the orbital anatomy on CT and MRI to be able to classify orbital masses. •Highlight image findings which may be useful to establish a differential diagnosis between benign and malignant lesions. •Analyze radiological findings in common...
Review of Russian Exhibits and Media Projects on the Centennial of the Russian Revolution
Creators: name: Lipilina, Natalia
Publisher: name: N. Lipilina, Review of Russian Exhibits and Media Projects on the Centennial of the Russian Revolution, «International Public History», 1, 2018, n. 2, pp. 1-18
Year: 2018
Subjects: Russia
Public history
Museum
Russian Revolution
Historical anniversaries
Exhibitions
History politics

description: The Russian Revolution of 1917 altered the fate and political landscape not only of Europe, but of the world. The article discusses the many exhibitions in Russia on the centenary of the Russian Revolution in major museums in Moscow and St. Petersburg, as well as in other parts of the country. In most exhibitions, poignant questions and conflicting memories put forth by different groups about the same events were strictly avoided, and many curators shied away from offering interpretations or making assessments as much as possible. What the jubilee year has shown is that the causes and consequences of the Revolution will continue to be studied and discussed.
Biomonitoring of firefighting forces: a review on biomarkers of exposure to health-relevant pollutants released from fires
Creators: name: Barros, Bela
name: Oliveira, Marta
name: Morais, Simone
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer

description: Occupational exposure as a firefighter has recently been classified as a carcinogen to humans by International Agency for Research on Cancer (IARC). Biomonitoring has been increasingly used to characterize exposure of firefighting forces to contaminants. However, available data are dispersed and information on the most relevant and promising biomarkers in this context of firefighting is missing. This review presents a comprehensive summary and critical appraisal of existing biomarkers of exposure including volatile organic compounds such as polycyclic aromatic hydrocarbons, several other persistent other organic pollutants as well as heavy metals and metalloids detected in biological fluids of firefighters attending different fire scenarios. Urine was the most characterized matrix, followed by blood. Firefighters exhaled breath and saliva were poorly evaluated. Overall, biological levels of compounds were predominantly increased in firefighters after participation in firefighting activities. Biomonitoring studies combining different biomarkers of exposure and of effect are currently limited but exploratory findings are of high interest. However, biomonitoring still has some unresolved major limitations since reference or recommended values are not yet established for most biomarkers. In addition, half-lives values for most of the biomarkers have thus far not been defined, which significantly hampers the design of studies. These limitations need to be tackled urgently to improve risk assessment and support implementation of better more effective preventive strategies.
Antitumor Agents. 284. New Desmosdumotin B Analogues with Bicyclic B-Ring as Cytotoxic and Antitubulin Agents
Creators: name: Zhang, Liying
name: Goto, Masuo
name: Nakagawa-Goto, Kyoko
name: Ohkoshi, Emika
name: Lee, Kuo-Hsiung
name: Kozaka, Takashi
name: Wu, Pei-Chi
name: Hamel, Ernest
name: Bastow, Kenneth F.
name: Lai, Chin-Yu
name: Zhu, Hao
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: We previously reported that the biological activity of analogues of desmosdumotin B (1) was dramatically changed depending on the B-ring system. A naphthalene B-ring analogue 3 exerted potent in vitro activity against a diverse panel of human tumor cell lines with GI50 values of 0.8–2.1 μM. In contrast, 1-analogues with a phenyl B-ring showed unique selective activity against P-glycoprotein (P-gp) overexpressing multidrug resistance cell line. We have now prepared and evaluated 1-analogues with bicyclic or tricyclic aromatic B-ring systems as in vitro inhibitors of human cancer cell line proliferation. Among all synthesized derivatives, 21 with a benzo[b]thiophenyl B-ring was highly active, with GI50 values of 0.06–0.16 μM, and this activity was not influenced by overexpression of P-gp. Furthermore, 21 inhibited tubulin assembly in vitro with an IC 50 value of 2.0 μM and colchicine binding by 78% as well as cellular microtubule polymerization and spindle formation.
Additional file 4 of Characteristics and recovery methods of studies falsely excluded during literature screening—a systematic review
Creators: name: Affengruber, Lisa
name: Dobrescu, Andreea
name: Persad, Emma
name: Klerings, Irma
name: Wagner, Gernot
name: Sommer, Isolde
name: Gartlehner, Gerald
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 4. Excluded studies at the full-text level.
Fiber counts and architecture of the human dorsal penile nerve
Creators: name: Tunçkol, Elçin
name: Purkart, Leopold
name: Eigen, Lennart
name: Vida, Imre
name: Brecht, Michael
Publisher: name: Humboldt-Universität zu Berlin
Year: 2023
Subjects: subject: Nervous system
subject: Peripheral nervous system
subject: 610 Medizin und Gesundheit

description: The article processing charge was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – 491192747 and the Open Access Publication Fund of Humboldt-Universität zu Berlin.
description: The human penis transmits behaviorally important sensory information via the dorsal penile nerve, which is required for initiation and maintenance of erection. The human penis differs from the penes of other hominids. The lack of a baculum makes the human penis dependent on erectile tissue, which is under control of neural signals activated by tactile stimulation. Accordingly, the penile sensory innervation is crucial for human sexual behavior. To clarify penile innervation, we analyzed the architecture of the dorsal penile nerve of five male subjects who donated their body. We stained the sensory fibers in the penile dorsal nerve with anti-neurofilament H antibody, and identified myelinated axons with Luxol fast blue staining. Furthermore, we visualized nerve bundles as they travel along the shaft of the penis by performing microfocus computed tomography scans after counterstaining penes with iodine. Our results show that the dorsal penile nerve is organized in 25–45 loosely packed nerve bundles, running mediodorsally in the shaft of the penis. This organization corresponds to that in penes of other mammalian species, but differs from the organization of the other peripheral sensory nerves. Around half of the dorsal penile nerve fibers were myelinated and a human hemipenis contained a total of 8290 ± 2553 (mean ± SD) axons. Thus, the number of sensory axons in the human dorsal penile nerve is higher than in other species described so far. The large fraction of unmyelinated nerve fibers suggests that the conduction speed is not a crucial aspect of penile sensory transmission.
title: Protocol and grading of ultrasound power Doppler signals measuring global disease activity in patients with rheumatoid arthritis
Creators: name: Gutierrez Rivera, Maria
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Musculoskeletal joint
subject: Musculoskeletal soft tissue
subject: Ultrasound
subject: Ultrasound-Power Doppler
subject: Diagnostic procedure
subject: Education
subject: Technical aspects
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The purpose of this educational exhibit is to describe the ultrasound hand scanning technique in assessing synovitis as a early finding and as a disease activity marker in the setting of rheumatoid arthritis (RA). Approaching to a basic ultrasound...
Defining the Structural Parameters That Confer Anticonvulsant Activity by the Site-by-Site Modification of ( R )- N ′-Benzyl 2-Amino-3-methylbutanamide
Creators: name: De Ryck, Marc
name: Stables, James P.
name: Kaminski, Rafal
name: Kohn, Harold
name: King, Amber M.
name: Valade, Anne
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Primary Amino Acid Derivatives (PAADs) (N′-benzyl 2-substituted 2-amino acetamides) are structurally related to Functionalized Amino Acids (FAAs) (N′-benzyl 2- substituted 2-acetamido acetamides) but differ by the absence of the terminal N-acetyl group. Both classes exhibit potent anticonvulsant activities in the maximal electroshock seizure animal model and the reported structure-activity relationships (SARs) of PAADs and FAAs differ in significant ways. Recently, we documented that PAAD efficacy was associated with a hydrocarbon moiety at the C(2)-carbon, while in the FAAs, a substituted heteroatom one atom removed from the C(2)-center was optimal. Previously in this issue, we showed that PAAD activity was dependent upon the electronic properties of the 4′-N′-benzylamide substituent, while FAA activity was insensitive to electronic changes at this site. In this study, we prepared analogs of (R)-N′-benzyl 2-amino-3-methylbutanamide to identify the structural components for maximal anticonvulsant activity. We demonstrated that the SAR of PAADs and FAAs diverged at the terminal amide site and that PAADs had considerably more structural latitude in the types of units that could be incorporated at this position, suggesting that these compounds function according to different mechanism(s).
Additional file 5 of Characteristics and recovery methods of studies falsely excluded during literature screening—a systematic review
Creators: name: Affengruber, Lisa
name: Dobrescu, Andreea
name: Persad, Emma
name: Klerings, Irma
name: Wagner, Gernot
name: Sommer, Isolde
name: Gartlehner, Gerald
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 5. Risk of bias of included studies.
Optimization of Cellular Activity of G9a Inhibitors 7-Aminoalkoxy-quinazolines
Creators: name: Huang, Jing
name: Vedadi, Masoud
name: Brown, Peter J.
name: Jin, Jian
name: Frye, Stephen V.
name: Allali-Hassani, Abdellah
name: Chen, Xin
name: Barsyte-Lovejoy, Dalia
name: He, Yunlong
name: Liu, Feng
name: Yates, Christopher M.
name: Arrowsmith, Cheryl H.
name: Herold, J. Martin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Protein lysine methyltransferase G9a plays key roles in the transcriptional repression of a variety of genes via dimethylation of lysine 9 on histone H3 (H3K9me2) of chromatin as well as dimethylation of non-histone proteins including tumor suppressor p53. We previously reported the discovery of UNC0321 (3), the most potent G9a inhibitor to date, via structure-based design and structure activity relationship (SAR) exploration of the quinazoline scaffold represented by BIX01294 (1). Despite its very high in vitro potency, compound 3 lacks sufficient cellular potency. The design and synthesis of several generations of new analogs aimed at improving cell membrane permeability while maintaining high in vitro potency resulted in the discovery of a number of novel G9a inhibitors such as UNC0646 (6) and UNC0631 (7) with excellent potency in a variety of cell lines and excellent separation of functional potency versus cell toxicity. The design, synthesis and cellular SAR of these potent G9a inhibitors are described.
Electric Dipole Moments: A Global Analysis
Creators: name: Chupp, Timothy
name: Ramsey-Musolf, Michael
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We perform a global analysis of searches for the permanent electric dipole moments (EDMs) of the neutron, neutral atoms, and molecules in terms of six leptonic, semileptonic, and nonleptonic interactions involving photons, electrons, pions, and nucleons. Translating the results into fundamental CP-violating effective interactions through dimension six involving Standard Model particles, we obtain rough lower bounds on the scale of beyond the Standard Model CP-violating interactions ranging from 1.5 TeV for the electron EDM to 1300 TeV for the nuclear spin-independent electron-quark interaction. We show that future measurements involving systems or combinations of systems with complementary sensitivities to the low-energy parameters may extend the mass reach by an order of magnitude or more.
description: 15 pages, 1 figure
title: Hydatid Disease: Imaging Findings of Intra and Extra-Abdominal Hydatidosis
Creators: name: Giambelluca, Dario
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Parasites
subject: Infection
subject: Cysts
subject: Contrast agent-intravenous
subject: Ultrasound
subject: MR
subject: CT
subject: Neuroradiology brain
subject: Lung
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Hidatidosis is a parasitic disease which is endemic in different regions of the world, including the Mediterranean region. In humans, liver is the most commonly involved site of hydatid disease; however, it may affect any part of the body, resulting...
The Diffusion Approximation vs. the Telegraph Equation for Modeling Solar Energetic Particle Transport with Adiabatic Focusing. I. Isotropic Pitch-angle Scattering
Creators: name: Effenberger, Frederic
name: Litvinenko, Yuri E.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Space Physics (physics.space-ph)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The diffusion approximation to the Fokker-Planck equation is commonly used to model the transport of solar energetic particles in interplanetary space. In this study, we present exact analytical predictions of a higher order telegraph approximation for particle transport and compare them with the corresponding predictions of the diffusion approximation and numerical solutions of the full Fokker-Planck equation. We specifically investigate the role of the adiabatic focusing effect of a spatially varying magnetic field on an evolving particle distribution. Comparison of the analytical and numerical results shows that the telegraph approximation reproduces the particle intensity profiles much more accurately than does the diffusion approximation, especially when the focusing is strong. However, the telegraph approximation appears to offer no significant advantage over the diffusion approximation for calculating the particle anisotropy. The telegraph approximation can be a useful tool for describing both diffusive and wavelike aspects of the cosmic-ray transport.
description: 7 pages, 8 figures, published in The Astrophysical Journal
title: Local complications of acute pancreatitis: from diagnosis to intervention
Creators: name: Onur, Mehmet Ruhi
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Abdomen
subject: Pancreas
subject: CT
subject: Percutaneous
subject: Complications
subject: Inflammation

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To discuss both diagnostic and interventional radiological approaches to local complications of acute...
ON THE PHYSICAL NATURE OF THE WILSON-BAPPU EFFECT: Revising the gravity and temperature dependence
Creators: name: Rosas-Portilla, Faiber
name: Schröder, Klaus-Peter
name: Jack, Dennis
Publisher: name: Zenodo
Year: 2023
Subjects: techniques: spectroscopic; stars: activity; stars: chromospheres; stars: fundamental parameters; stars: late-type

description: The Wilson-Bappu effect (WBE; Wilson & Bappu, 1957) is a well-known empirical relation for cool and giants stars between the K emission line width of Ca II and the absolute visual magnitude. To date, however, the underlying physical relation of the WBE with stellar parameters, in particular gravity and effective temperature, has not been fully established, nor its physical nature. This motivated us to find a physical relation of the WBE by current means, using a sample of 32 well-known late-type stars, with moderate activity levels, which covers four orders of magnitude of surface gravity and a representative range of effective temperature. For each star we obtained high signal-to-noise ratio (S/N) spectra from the Telescopio Internacional de Guanajuato Robótico-Espectroscópico (TIGRE-HEROS, Schmitt et al. 2014) with a spectral resolving power of R ~ 20,000 and measured the Ca II K line widths of interest, W0 and W1. The main physical parameters were determined by means of ISPEC synthesis and Gaia EDR3 parallaxes (Gaia Collaboration et al. 2021). Mass estimates are based on matching to evolution models.
description: {"references": ["Ayres, T. R. (1979), ApJ, 228, 509", "Ayres, T. R. (2019), in The Sun as a Guide to Stellar Physics. Elsevier, pp 27\u20135", "Ayres, T. R. et al. (1975), ApJ, 195, L121", "Blanco-Cuaresma, S. (2019), MNRAS, 486, 2075", "Blanco-Cuaresma, S. et al. (2014), A&A, 569, A111", "Gaia Collaboration et al. (2021), A&A, 649, A1", "Pols, O. R. et al. (1997), MNRAS, 289, 869", "Pols, O. R. et al. (1998), MNRAS, 298, 525", "Schmitt, J. H. M. M. et al. (2014), Astron. Nachr., 335, 787", "Wilson, O. C. et al. (1957), ApJ, 125, 661"]}
Pyrimidine Nucleotides with 4-Alkyloxyimino and Terminal Tetraphosphate δ-Ester Modifications as Selective Agonists of the P2Y 4 Receptor
Creators: name: Costanzi, Stefano
name: de Castro, Sonia
name: Kim, Nathaniel
name: Jacobson, Kenneth A.
name: Maruoka, Hiroshi
name: Franklin, Derek A.
name: Harden, T. Kendall
name: Jayasekara, M. P. Suresh
name: Barrett, Matthew O.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: P2Y2 and P2Y4 receptors are G protein-coupled receptors, activated by UTP and dinucleoside tetraphosphates, which are difficult to distinguish pharmacologically for lack of potent and selective ligands. We varied structurally phosphate and uracil moieties in analogues of pyrimidine nucleoside 5′-triphosphates and 5′-tetraphosphate esters. P2Y4 receptor potency in phospholipase C stimulation in transfected 1321N1 human astrocytoma cells was enhanced in N4-alkyloxycytidine derivatives. OH groups on a terminal δ-glucose phosphoester of uridine 5′-tetraphosphate were inverted or substituted with H or F to probe H-bonding effects. N4-(Phenylpropoxy)-CTP 16 (MRS4062), Up4-[1]3′-deoxy-3′-fluoroglucose 34 (MRS2927) and N4-(phenylethoxy)-CTP 15 exhibit ≥10-fold selectivity for human P2Y4 over P2Y2 and P2Y6 receptors (EC50 values 23, 62 and 73 nM, respectively). δ-3-Chlorophenyl phosphoester 21 of Up4 activated P2Y2 but not P2Y4 receptor. Selected nucleotides tested for chemical and enzymatic stability were much more stable than UTP. Agonist docking at CXCR4-based P2Y2 and P2Y4 receptor models indicated greater steric tolerance of N4-phenylpropoxy group at P2Y4. Thus, distal structural changes modulate potency, selectivity, and stability of extended uridine tetraphosphate derivatives, and we report the first P2Y4 receptor-selective agonists.