cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A New Small Molecule Inhibitor of Estrogen Receptor α Binding to Estrogen Response Elements Blocks Estrogen-dependent Growth of Cancer Cells
Creators: name: Putt, Karson S.
name: Cherian, Milu T.
name: Wilson, Elizabeth M.
name: Hergenrother, Paul J.
name: Nordeen, Steven K.
name: Cheng, Jingwei
name: Nardulli, Ann M.
name: Aninye, Irene O.
name: Zhang, Chen
name: Mao, Chengjian
name: Shapiro, David J.
name: Patterson, Nicole M.
name: Montoya, Jamie Bonéy
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Estrogen receptor α (ERα) plays an important role in several human cancers. Most current ERα antagonists bind in the receptor ligand binding pocket and compete for binding with estrogenic ligands. Instead of the traditional approach of targeting estrogen binding to ER, we describe a strategy using a high throughput fluorescence anisotropy microplate assay to identify small molecule inhibitors of ERα binding to consensus estrogen response element (cERE) DNA. We identified small molecule inhibitors of ERα binding to the fluorescein-labeled (fl)cERE and evaluated their specificity, potency, and efficacy. One small molecule, theophylline, 8-[(benzylthio)methyl]-(7CI,8CI) (TPBM), inhibited ERα binding to the flcERE (IC50 ∼ 3 μm) and inhibited ERα-mediated transcription of a stably transfected ERE-containing reporter gene. Inhibition by TPBM was ER-specific, because progesterone and glucocorticoid receptor transcriptional activity were not significantly inhibited. In tamoxifen-resistant breast cancer cells that overexpress ERα, TPBM inhibited 17β-estradiol (E2)-ERα (IC50 9 μm) and 4-hydroxytamoxifen-ERα-mediated gene expression. Chromatin immunoprecipitation showed TPBM reduced E2·ERα recruitment to an endogenous estrogen-responsive gene. TPBM inhibited E2-dependent growth of ERα-positive cancer cells (IC50 of 5 μm). TPBM is not toxic to cells and does not affect estrogen-independent cell growth. TPBM acts outside of the ER ligand binding pocket, does not act by chelating the zinc in ER zinc fingers, and differs from known ERα inhibitors. Using a simple high throughput screen for inhibitors of ERα binding to the cERE, a small molecule inhibitor has been identified that selectively inhibits ERα-mediated gene expression and estrogen-dependent growth of cancer cells.
Armorloricus, a new genus of Loricifera (Nanaloricidae) from Trezen ar Skoden (Roscoff, France)
Creators: name: MOBJERG KRISTENSEN, Reinhardt
name: GAD, Gunnar
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2004

description: Two new species of Loricifera (Nanaloricidae), Armorloricus elegans sp. nov. and A. davidi sp. nov. are described
 as representatives of a new genus from the sediment of Trezen ar Skoden (Roscoff, France) in the vicinity of the type locality
 of Nanaloricus mysticus. Diagnosis and description are based on all life history instars: adults, postlarvae, and Higgins-
 larvae, all collected from the upper surface layer of shell gravel at 50-55 m depth. The adults of the new genus are
 characterized by a smooth lorica with large midventral and laterodorsal plates. The dorsal plate of the lorica is longitudinally
 subdivided into three additional plates. The short mouth cone has an extremely long mouth tube. The clavoscalids and
 lateroventral trichoscalids display sexual dimorphism in both species. In the males the clavoscalids possess next to the main
 branch two additional club-shaped branches. The leglike scalids of the second row are smooth, strongly sclerotized, and
 distally as broad as the clavoscalids. Internally, the prepharyngeal armature of adults is equipped with an additional posterior
 part called the manubrium, which consists of three fused bracelets. The respective stout Higgins-larvae display an angular
 lorica and toes winged by two short mucrones ending distally in spared tips. Both the toes and the lorica have a honeycomb
 sculpture. Additional larval features are short, solid scalids covering the introvert and short locomotory appendages inserting
 ventrally on the trunk. The distinguishing characters of Armorloricus gen. nov. and Nanaloricus are discussed in detail. Apart
 from Nanaloricus, this is the first report of an additional taxon of the Nanaloricidae, which results in a revision of the
 characters at the family level. Investigations of the type material indicate a highly modified status of the Nanaloricidae,
 which can be shown e.g. in the transformation and arrangement of scalids in the adults and even in the Higgins-larvae.
 Therefore new scalid distribution schemes of all life instars
A Point Mutation to Gαi Selectively Blocks GoLoco Motif Binding: DIRECT EVIDENCE FOR Gα·GoLoco COMPLEXES IN MITOTIC SPINDLE DYNAMICS*S⃞
Creators: name: Lambert, Nevin A.
name: Zheng, Zhen
name: Ikeda, Stephen R.
name: Watts, Val J.
name: Johnston, Christopher A.
name: Siderovski, David P.
name: Bosch, Dustin
name: Digby, Gregory J.
name: Guo, Juan
name: Kimple, Adam J.
name: Du, Quansheng
name: Willard, Melinda D.
name: Conley, Jason M.
name: Willard, Francis S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Heterotrimeric G-protein Gα subunits and GoLoco motif proteins are key members of a conserved set of regulatory proteins that influence invertebrate asymmetric cell division and vertebrate neuroepithelium and epithelial progenitor differentiation. GoLoco motif proteins bind selectively to the inhibitory subclass (Gαi) of Gα subunits, and thus it is assumed that a Gαi·GoLoco motif protein complex plays a direct functional role in microtubule dynamics underlying spindle orientation and metaphase chromosomal segregation during cell division. To address this hypothesis directly, we rationally identified a point mutation to Gαi subunits that renders a selective loss-of-function for GoLoco motif binding, namely an asparagine-to-isoleucine substitution in the αD-αE loop of the Gα helical domain. This GoLoco-insensitivity (“GLi”) mutation prevented Gαi1 association with all human GoLoco motif proteins and abrogated interaction between the Caenorhabditis elegans Gα subunit GOA-1 and the GPR-1 GoLoco motif. In contrast, the GLi mutation did not perturb any other biochemical or signaling properties of Gαi subunits, including nucleotide binding, intrinsic and RGS protein-accelerated GTP hydrolysis, and interactions with Gβγ dimers, adenylyl cyclase, and seven transmembrane-domain receptors. GoLoco insensitivity rendered Gαi subunits unable to recruit GoLoco motif proteins such as GPSM2/LGN and GPSM3 to the plasma membrane, and abrogated the exaggerated mitotic spindle rocking normally seen upon ectopic expression of wild type Gαi subunits in kidney epithelial cells. This GLi mutation should prove valuable in establishing the physiological roles of Gαi·GoLoco motif protein complexes in microtubule dynamics and spindle function during cell division as well as to delineate potential roles for GoLoco motifs in receptor-mediated signal transduction.
An exactly solvable system from quantum optics
Creators: name: Maciejewski, Andrzej J.
name: Przybylska, Maria
name: Stachowiak, Tomasz
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We investigate a generalisation of the Rabi system in the Bargmann-Fock representation. In this representation the eigenproblem of the considered quantum model is described by a system of two linear differential equations with one independent variable. The system has only one irregular singular point at infinity. We show how the quantisation of the model is related to asymptotic behaviour of solutions in a vicinity of this point. The explicit formulae for the spectrum and eigenfunctions of the model follow from an analysis of the Stokes phenomenon. An interpretation of the obtained results in terms of differential Galois group of the system is also given.
description: 9 pages, 5 figures
Additional file 3 of Corncob structures in dental plaque reveal microhabitat taxon specificity
Creators: name: Morillo-Lopez, Viviana
name: Sjaarda, Alexandra
name: Islam, Imon
name: Borisy, Gary G.
name: Mark Welch, Jessica L.
Publisher: name: figshare
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional file 3. Ribosomal RNA-targeted oligonucleotide probes used in this study and their combination into probe sets [62–64].
Single-shot Readout of a Superconducting Qubit using a Josephson Parametric Oscillator
Creators: name: Krantz, Philip
name: Bengtsson, Andreas
name: Simoen, Michaël
name: Gustavsson, Simon
name: Shumeiko, Vitaly
name: Oliver, W. D.
name: Wilson, C. M.
name: Delsing, Per
name: Bylander, Jonas
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We propose and demonstrate a new read-out technique for a superconducting qubit by dispersively coupling it to a Josephson parametric oscillator. We employ a tunable quarter-wavelength superconducting resonator and modulate its resonant frequency at twice its value with an amplitude surpassing the threshold for parametric instability. We map the qubit states onto two distinct states of classical parametric oscillation: one oscillating state, with $185\pm15$ photons in the resonator, and one with zero oscillation amplitude. This high contrast obviates a following quantum-limited amplifier. We demonstrate proof-of-principle, single-shot readout performance, and present an error budget indicating that this method can surpass the fidelity threshold required for quantum computing.
description: 11 pages, 5 figures
A redescription and new host record for the parasitic isopod Pseudione tuberculata (Epicaridea: Bopyridae) from the Beagle Channel, Argentina
Creators: name: MIRANDA-VARGAS, Patricia
name: ROCCATAGLIATA, Daniel
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2004

description: The branchial bopyrid Pseudione tuberculata infests species of the family Lithodidae (Anomura). Previously
 known as a parasite of Neolithodes diomedeae off Archipelago de los Chonos, Chile, and Paralomis granulosa from shallow
 waters in the Beagle Channel, Argentina, it is herein reported from a new host, Lithodes santolla, also from shallow waters
 in the Beagle Channel, Argentina. The female and male of Pseudione tuberculata are redescribed in detail and fully
 illustrated. A comparison of the specimens from the Beagle Channel with those of the type series, and comments on the
 distribution of P. tuberculata are included.
Normative Data for the Five Factor Model Antagonistic Triad Measure from a Representative Sample
Creators: name: Rose, Leigha
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Clinical Psychology
subject: Social Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: This project aims to collect a nationally representative normative sample for the Five Factor Model Antagonistic Triad Measure (FFM ATM). Data will be collected via Prolific.
title: Ultrasound Diagnosis and Non-Operative Management of Flexor Pollicis Longus Tendon Rupture - A Case Report
Creators: name: Ghasemzadeh, Milad
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Extremities
subject: Musculoskeletal soft tissue
subject: Musculoskeletal joint
subject: Ultrasound
subject: History
subject: Observer performance
subject: Trauma

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: To explore the use of ultrasound imaging to aid diagnosis in closed flexor pollicis longus (FPL) tendon rupture, through the discussed case. To explore the outcomes of non-operative management of FPL tendon rupture, through the discussed...
Adenylic Dinucleotides Produced by CD38 Are Negative Endogenous Modulators of Platelet Aggregation
Creators: name: Basile, Giovanna
name: Nicholas, Robert A.
name: Zocchi, Elena
name: Chothi, Madhu Parakkottil
name: Magnone, Mirko
name: Leoncini, Giuliana
name: Kassack, Matthias U.
name: Bruzzone, Santina
name: Qi, Ai Dong
name: Signorello, Maria Grazia
name: Bruzzese, Debora
name: Guida, Lucrezia
name: Millo, Enrico
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Diadenosine 5′,5‴-P1,P2-diphosphate (Ap2A) is one of the adenylic dinucleotides stored in platelet granules. Along with proaggregant ADP, it is released upon platelet activation and is known to stimulate myocyte proliferation. We have previously demonstrated synthesis of Ap2A and of two isomers thereof, called P18 and P24, from their high pressure liquid chromatography retention time, by the ADP-ribosyl cyclase CD38 in mammalian cells. Here we show that Ap2A and its isomers are present in resting human platelets and are released during thrombin-induced platelet activation. The three adenylic dinucleotides were identified by high pressure liquid chromatography through a comparison with the retention times and the absorption spectra of purified standards. Ap2A, P18, and P24 had no direct effect on platelet aggregation, but they inhibited platelet aggregation induced by physiological agonists (thrombin, ADP, and collagen), with mean IC50 values ranging between 5 and 15 μm. Moreover, the three dinucleotides did not modify the intracellular calcium concentration in resting platelets, whereas they significantly reduced the thrombin-induced intracellular calcium increase. Through binding to the purinergic receptor P2Y11, exogenously applied Ap2A, P18, and P24 increased the intracellular cAMP concentration and stimulated platelet production of nitric oxide, the most important endogenous antiaggregant. The presence of Ap2A, P18, and P24 in resting platelets and their release during thrombin-induced platelet activation at concentrations equal to or higher than the respective IC50 value on platelet aggregation suggest a role of these dinucleotides as endogenous negative modulators of aggregation.
title: 'Digitale Intellektuelle': Ego-Dokumente und Selbstzeugnisse in digitalen Datenbanken
Creators: name: Van Koert, Rebecca
Publisher: name: MAP - Modern Academic Publishing, Universität zu Köln
Year: 2016

description: Virtuosen der Öffentlichkeit? Friedrich von Gentz (1764-1832) im globalen intellektuellen Kontext seiner Zeit
title: Vasculitis of the buccal fat pad, presenting as a soft tissue mass: Imaging findings
Creators: name: Oh, Geon
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Head and neck
subject: MR
subject: Biopsy
subject: Inflammation

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: 1. Introduce imaging features of vasculitis of the buccal fat pad, presenting as a soft tissue mass. 2. Review of buccal space anatomy and common pathologies. 3. Review of eosinophilic granulomatosis with polyangiitis...
Cdt1 and Cdc6 Are Destabilized by Rereplication-induced DNA Damage
Creators: name: Dorn, Elizabeth S.
name: Lee, Hyun O.
name: Bunker, Brandon D.
name: Duronio, Robert J.
name: Hall, Jonathan R.
name: Cook, Jeanette Gowen
name: Rogers, Greg C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The replication factors Cdt1 and Cdc6 are essential for origin licensing, a prerequisite for DNA replication initiation. Mechanisms to ensure that metazoan origins initiate once per cell cycle include degradation of Cdt1 during S phase and inhibition of Cdt1 by the geminin protein. Geminin depletion or overexpression of Cdt1 or Cdc6 in human cells causes rereplication, a form of endogenous DNA damage. Rereplication induced by these manipulations is however uneven and incomplete, suggesting that one or more mechanisms restrain rereplication once it begins. We find that both Cdt1 and Cdc6 are degraded in geminin-depleted cells. We further show that Cdt1 degradation in cells that have rereplicated requires the PCNA binding site of Cdt1 and the Cul4DDB1 ubiquitin ligase, and Cdt1 can induce its own degradation when overproduced. Cdc6 degradation in geminin-depleted cells requires Huwe1, the ubiquitin ligase that regulates Cdc6 after DNA damage. Moreover, perturbations that specifically disrupt Cdt1 and Cdc6 degradation in response to DNA damage exacerbate rereplication when combined with geminin depletion, and this enhanced rereplication occurs in both human cells and in Drosophila melanogaster cells. We conclude that rereplication-associated DNA damage triggers Cdt1 and Cdc6 ubiquitination and destruction, and propose that this pathway represents an evolutionarily conserved mechanism that minimizes the extent of rereplication.
(4055) margaret Blair
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Effect of videos on children’s confidence in keeping still for a MRI scan.
Creators: name: Tang, Phua Hwee
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Paediatric
subject: MR
subject: Comparative studies
subject: Education and training

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: The purpose of this project was to evaluate the effect of videos on children’s confidence to keep still for the MRI scan. MRI use is increasing as this imaging modality gives great detail of internal body structures a safe manner and can be used...
Control of MAPK Specificity by Feedback Phosphorylation of Shared Adaptor Protein Ste50
Creators: name: Zeng, Yaxue
name: Elston, Timothy C.
name: Hao, Nan
name: Dohlman, Henrik G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Many different signaling pathways share common components but nevertheless invoke distinct physiological responses. In yeast, the adaptor protein Ste50 functions in multiple mitogen-activated protein (MAP) kinase pathways, each with unique dynamical and developmental properties. Although Kss1 activity is sustained and promotes invasive growth, Hog1 activity is transient and promotes cell adaptation to osmotic stress. Here we show that osmotic stress activates Kss1 as well as Hog1. We show further that Hog1 phosphorylates Ste50 and that phosphorylation of Ste50 limits the duration of Kss1 activation and prevents invasive growth under high osmolarity growth conditions. Thus feedback regulation of a shared component can restrict the activity of a competing MAP kinase to ensure signal fidelity.
Deletion of the Protein Kinase A/Protein Kinase G Target SMTNL1 Promotes an Exercise-adapted Phenotype in Vascular Smooth Muscle
Creators: name: McCook, Everett
name: Yan, Zhen
name: Somlyo, Avril V.
name: Neppl, Ronald L.
name: Thresher, Randy J.
name: Haystead, Timothy A.J.
name: Gavin, Timothy P.
name: Miller, Sara E.
name: Fortner, Christopher N.
name: Li, Ping
name: Perriard, Jean Claude
name: Coffman, Thomas M.
name: Lontay, Beata
name: Akimoto, Takayuki
name: Wooldridge, Anne A.
name: Kwon, Ashley
name: Datto, Michael B.
name: Wang, Shiliang
name: Hickner, Robert C.
name: Facemire, Carie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: In vivo protein kinases A and G (PKA and PKG) coordinately phosphorylate a broad range of substrates to mediate their various physiological effects. The functions of many of these substrates have yet to be defined genetically. Herein we show a role for smoothelin-like protein 1 (SMTNL1), a novel in vivo target of PKG/PKA, in mediating vascular adaptations to exercise. Aortas from smtnl1-/- mice exhibited strikingly enhanced vasorelaxation before exercise, similar in extent to that achieved after endurance training of wild-type littermates. Additionally, contractile responses to α-adrenergic agonists were greatly attenuated. Immunological studies showed SMTNL1 is expressed in smooth muscle and type 2a striated muscle fibers. Consistent with a role in adaptations to exercise, smtnl1-/- mice also exhibited increased type 2a fibers before training and better performance after forced endurance training compared smtnl1+/+ mice. Furthermore, exercise was found to reduce expression of SMTNL1, particularly in female mice. In both muscle types, SMTNL1 is phosphorylated at Ser-301 in response to adrenergic signals. In vitro SMTNL1 suppresses myosin phosphatase activity through a substrate-directed effect, which is relieved by Ser-301 phosphorylation. Our findings suggest roles for SMTNL1 in cGMP/cAMP-mediated adaptations to exercise through mechanisms involving direct modulation of contractile activity.
A "Lagrangian" for a non-Lagrangian theory
Creators: name: Gadde, Abhijit
name: Razamat, Shlomo S.
name: Willett, Brian
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We suggest an N=1 Lagrangian flowing in the infra-red to the N=2 rank one superconformal field theory with E_6 flavor symmetry. We utilize this description to compute several supersymmetric partition functions.
description: 4 pages, Mathematica notebook attached
Immunogenicity and safety of concomitant bivalent COVID-19 and quadrivalent influenza vaccination: Implications of immune imprinting and interference
Creators: name: Choi, MinJoo
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Medicine and Health Sciences
subject: Life Sciences

description: this study aimed to evaluate the immunogenicity and safety of concomitant BA.5-based bivalent COVID-19 and influenza vaccination during the 2022-2023 season.
Dual Activation of Phospholipase C-ϵ by Rho and Ras GTPases
Creators: name: Harden, T. Kendall
name: Seifert, Jason P.
name: Hicks, Stephanie N.
name: Zhou, Yixing
name: Sondek, John
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Phospholipase C-ε (PLC-ε) is a highly elaborated PLC required for a diverse set of signaling pathways. Here we use a combination of cellular assays and studies with purified proteins to show that activated RhoA and Ras isoforms directly engage distinct regions of PLC-ε to stimulate its phospholipase activity. Purified PLC-ε was activated in a guanine nucleotide- and concentration-dependent fashion by purified lipidated K-Ras reconstituted in PtdIns(4,5)P2-containing phospholipid vesicles. Whereas mutation of two critical lysine residues within the second Ras-association domain of PLC-ε prevented K-Ras-dependent activation of the purified enzyme, guanine nucleotide-dependent activation by RhoA was retained. Deletion of a loop unique to PLC-ε eliminated its activation by RhoA but not H-Ras. In contrast, removal of the autoinhibitory X/Y-linker region of the catalytic core of PLC-ε markedly activates the enzyme (Hicks, S. N., Jezyk, M. R., Gershburg, S., Seifert, J. P., Harden, T. K., and Sondek, J. (2008) Mol. Cell, 31, 383–394), but PLC-ε lacking this regulatory region retained activation by both Rho and Ras GTPases. Additive activation of PLC-ε by RhoA and K- or H-Ras was observed in intact cell studies, and this additivity was recapitulated in experiments in which activation of purified PLC-ε was quantified with PtdIns(4,5)P2-containing phospholipid vesicles reconstituted with purified, isoprenylated GTPases. A maximally effective concentration of activated RhoA also increased the sensitivity of purified PLC-ε to activation by K-Ras. These results indicate that PLC-ε can be directly and concomitantly activated by both RhoA and individual Ras GTPases resulting in diverse upstream control of signaling cascades downstream of PLC-ε.
SRT performance measurements (2018-2021)
Creators: name: Egron, Elise
name: Vacca, V.
name: Carboni, G.
name: Pili, M.
name: Loru, S.
name: Castangia, P.
name: Pellizzoni, Alberto
name: SERRA, Giampaolo
name: IACOLINA, Maria Noemi
name: VALENTE, Giuseppe
name: ATTOLI, Alessandro
name: Buffa, F.
name: Mulas, S.
name: Perrodin, D.
name: Poppi, S.
name: Bachetti, M.
name: Burgay, M.
name: Caria, M. T.
name: Carretti, E.
name: Casu, S.
name: Concu, R.
name: Corongiu, A.
name: Deiana, G. L.
name: Fara, Antonietta
name: Gaudiomonte, F.
name: Ladu, A.
name: MARCHEGIANI, Paolo
name: MAXIA, PAOLO
name: Melis, A.
name: Milia, S.
name: Migoni, C.
name: Navarrini, A.
name: Orlati, A.
name: Ortu, P.
name: Palmas, S.
name: Pilia, M.
name: Pisanu, T.
name: SABA, Andrea
name: Schirru, L.
name: Soletta, P.
name: Surcis, G.
name: Tarchi, A.
name: URRU, Enrico
name: VARGIU, GIAN PAOLO
Publisher: name: O.A. Cagliari
Year: 2022

description: Tests of characterization are periodically performed at SRT in order to check the status of the antenna, ensure a good functioning of the different components (e.g. active surface, receivers, backends, etc), and improve the observing performances at the different frequencies. In particular, the tests include measurements of beam shape, pointing, gain curves and focus for the different receivers (L, C, X and K-bands). We report the results of the main tests carried out after a long stop of the antenna due to the reparation of the main servo motors chillers in 2020 and compare them with those carried out during the recommissioning in 2018 (after the change of the actuators of the active surface). These results will be useful in order to compare the new status of the antenna after the upgrade of the new receivers at higher frequency (PON).
Effects of Structure of Rho GTPase-activating Protein DLC-1 on Cell Morphology and Migration
Creators: name: Der, Channing J.
name: Sciaky, Noah
name: Bang, Yung Jue
name: Healy, Kevin D.
name: Tai, Young Kim
name: Juliano, Rudy L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: DLC-1 encodes a Rho GTPase-activating protein (RhoGAP) and negative regulator of specific Rho family proteins (RhoA-C and Cdc42). DLC-1 is a multi-domain protein, with the RhoGAP catalytic domain flanked by an amino-terminal sterile α motif (SAM) and a carboxyl-terminal START domain. The roles of these domains in the regulation of DLC-1 function remain to be determined. We undertook a structure-function analysis involving truncation and missense mutants of DLC-1. We determined that the amino-terminal SAM domain functions as an autoinhibitory domain of intrinsic RhoGAP activity. Additionally, we determined that the SAM and START domains are dispensable for DLC-1 association with focal adhesions. We then characterized several mutants for their ability to regulate cell migration and identified constitutively activated and dominant negative mutants of DLC-1. We report that DLC-1 activation profoundly alters cell morphology, enhances protrusive activity, and can increase the velocity but reduce directionality of cell migration. Conversely, the expression of the amino-terminal domain of DLC-1 acts as a dominant negative and profoundly inhibits cell migration by displacing endogenous DLC-1 from focal adhesions.
Reproductive biology of anchovy Engraulis encrasicolus from the North eastern coast of Algeria (SW-Mediterranean)
Creators: name: LADAIMIA, Souâd
name: BOUHALI, Fatima Zohra
name: BENCHIKH, Nadira
name: DIAF, Assia
name: DJEBAR, Abdallah Borhane
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2016

description: This paper investigates the reproductive biology of anchovy Engraulis encrasicolus from El- Kala area off the extreme Eastern Algeria during an annual cycle. Male and female percentages vary with size, but annual sex ratio is not significantly different from the 1:1 ratio. Length-weight relationship indicates a positive allometric growth (b > 3). The size at 50% maturity (Lm50) was 10.71cm in males and 9.86 cm in females. When sexual maturity is reached, anchovies spawn between March and October with one peak spawning in May. Condition factor (K) increases between November and February. It decreases during the reproductive period, but feeding continues during this season. Ovary histological analysis shows that vitellogenesis extends from March to October. Anchovy is a multiple-spawning small pelagic fish which reproduces by asynchronous oocyte development. Potential annual fecundity (F) ranges between 5222 and 50390 (mean: 24757 ± 13222) oocytes per spawning female for an average size of 15 cm and a mean weight of 22.9 g. Relative fecundity (Fr) ranges between 387 and 1976 (1091± 492) oocytes per gram of somatic weight. A strong correlation exists between absolute fecundity and total weight, somatic weight, ovary weight and total length (r > 0.70).
(4052) Janet Morris
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Enamel Defects and Ameloblast-specific Expression in Enam Knock-out /lacZ Knock-in Mice
Creators: name: Yamakoshi, Yasuo
name: McKee, Marc D.
name: Hunter, Graeme K.
name: Smith, Charles E.
name: Hu, Jan C.C.
name: Papagerakis, Petros
name: Simmer, James P.
name: Yamakoshi, Fumiko
name: Feng, Jerry Q.
name: Hu, Yuanyuan
name: Wright, J. Timothy
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Enamelin is critical for proper dental enamel formation, and defects in the human enamelin gene cause autosomal dominant amelogenesis imperfecta. We used gene targeting to generate a knock-in mouse carrying a null allele of enamelin (Enam) that has a lacZ reporter gene replacing the Enam translation initiation site and gene sequences through exon 7. Correct targeting of the transgene was confirmed by Southern blotting and PCR analyses. No enamelin protein could be detected by Western blotting in the Enam-null mice. Histochemical 5-bromo-4-chloro-3-indolyl-β-d-galactopyranoside (X-gal) staining demonstrated ameloblast-specific expression of enamelin. The enamel of the Enam+/- mice was nearly normal in the maxillary incisors, but the mandibular incisors were discolored and tended to wear rapidly where they contacted the maxillary incisors. The Enam-/- mice showed no true enamel. Radiography, microcomputed tomography, and light and scanning electron microscopy were used to document changes in the enamel of Enam-/- mice but did not discern any perturbations of bone, dentin, or any other tissue besides the enamel layer. Although a thick layer of enamel proteins covered normal-appearing dentin of unerupted teeth, von Kossa staining revealed almost a complete absence of mineral formation in this protein layer. However, a thin, highly irregular, mineralized crust covered the dentin on erupted teeth, apparently arising from the formation and fusion of small mineralization foci (calcospherites) in the deeper part of the accumulated enamel protein layer. These results demonstrate ameloblast-specific expression of enamelin and reveal that enamelin is essential for proper enamel matrix organization and mineralization.
title: Die Revolution kehrt zurück : "Le Constitutionnel", die Pariser Presse und Friedrich von Gentz (1815-1830)
Creators: name: Klesmann, Bernd
Publisher: name: MAP - Modern Academic Publishing, Universität zu Köln
Year: 2016

description: Virtuosen der Öffentlichkeit? Friedrich von Gentz (1764-1832) im globalen intellektuellen Kontext seiner Zeit
title: Os Trigonum Fracture: An unusual injury.
Creators: name: Sekhon, Rupinder
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Musculoskeletal bone
subject: Musculoskeletal system
subject: CT
subject: Digital radiography
subject: Education
subject: Trauma

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: The Os Trigonum is one of the largest and most common accessory ossicles of the foot. Fractures of the Os Trigonum are extremely rare and it may be radiographically confused with a fracture of the posterior process of the talus. There should be a...
(4049) George Comb
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Knowledge, attitude and practices of pakistani radiologists toward radiological research
Creators: name: Saeed, Muhammad Arif
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Education and training
subject: Education
subject: Audit and standards
subject: Statistics
subject: Ultrasound
subject: MR
subject: CT
subject: Professional issues
subject: Workforce
subject: Outcomes

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Radiology is one of the main cornerstones in the optimal management of diseases. 1 All advancements and innovations have come forward due to extensive research. It is important to carry out research along with clinical duties to carry forward...
title: Chemoradiotherapy versus chemotherapy for unresectable pancreatic cancer: A systematic review and meta-analysis
Creators: name: Ng, Ivy
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Abdomen
subject: Oncology
subject: Pancreas
subject: CT
subject: Chemotherapy
subject: Radiation therapy / Oncology
subject: Neoplasia

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Surgical resection offers the only chance of cure for non-metastatic pancreatic cancer Only 15 to 20% of patients have potentially resectable disease at diagnosis 30 to 40% have locally advanced unresectable tumours•Optimal management of this...
Nuclear polarization study: New frontiers for tests of QED in heavy highly charged ions
Creators: name: Volotka, Andrey V.
name: Plunien, Günter
Publisher: name: arXiv
Year: 2015
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: A systematic investigation of the nuclear-polarization effects in one- and few-electron heavy ions is presented. The nuclear-polarization corrections in the zeroth and first orders in $1/Z$ are evaluated to the binding energies, the hyperfine splitting, and the bound-electron g factor. It is shown, that the nuclear-polarization contributions can be substantially canceled simultaneously with the rigid nuclear corrections. This allows for new prospects for probing the QED effects in strong electromagnetic field and the determination of fundamental constants.
description: 5 pages, 4 figures
Identification of a Protective Role for Protein Phosphatase 1cγ1 against Oxidative Stress-induced Vascular Smooth Muscle Cell Apoptosis
Creators: name: Niu, Xi Lin
name: Vendrov, Aleksandr E.
name: Tchivilev, Igor
name: Madamanchi, Nageswara R.
name: Runge, Marschall S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The development of therapeutic strategies to inhibit reactive oxygen species (ROS)-mediated damage in blood vessels has been limited by a lack of specific targets for intervention. Targeting ROS-mediated events in the vessel wall is of interest, because ROS play important roles throughout atherogenesis. In early atherosclerosis, ROS stimulate vascular smooth muscle cell (VSMC) growth, whereas in late stages of lesion development, ROS induce VSMC apoptosis, causing atherosclerotic plaque instability. To identify putative protective genes against oxidative stress, mouse aortic VSMC were infected with a retroviral human heart cDNA expression library, and apoptosis was induced in virus-infected cells by 2,3-dimethoxy-1,4-naphthoquinone (DMNQ) treatment. A total of 17 different, complete cDNAs were identified from the DMNQ-resistant VSMC clones by PCR amplification and sequencing. The cDNA encoding PP1cγ1 (catalytic subunit of protein phosphatase 1) was present in several independent DMNQ-resistant VSMC clones. DMNQ increased mitochondrial ROS production, caspase-3/7 activity, DNA fragmentation, and decreased mitochondrial transmembrane potential in VSMC while decreasing PP1cγ1 activity and expression. Depletion of PP1cγ1 expression by short hairpin RNA significantly enhanced basal as well as DMNQ-induced VSMC apoptosis. PP1cγ1 overexpression abrogated DMNQ-induced JNK1 activity, p53 Ser15 phosphorylation, and Bax expression and protected VSMC against DMNQ-induced apoptosis. In addition, PP1cγ1 overexpression attenuated DMNQ-induced caspase-3/7 activation and DNA fragmentation. Inhibition of p53 protein expression using small interfering RNA abrogated DMNQ-induced Bax expression and significantly attenuated VSMC apoptosis. Together, these data indicate that PP1cγ1 overexpression promotes VSMC survival by interfering with JNK1 and p53 phosphorylation cascades involved in apoptosis.
title: Percutaneous trans-hepatic endovascular embolisation of intrahepatic porto-systemic shunts in a patient with medically refractory hepatic encephalopathy
Creators: name: Oh, Geon
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Interventional vascular
subject: Catheter venography
subject: Embolisation
subject: Arteriovenous malformations

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: Understandpercutaneous trans-hepatic endovascular embolisation is a safe and effacacious treatment of choice for patients withmedically refractory hepatic encephalopathy secondary tointrahepatic portosystemic...
On Useful Conformal Tranformations In General Relativity
Creators: name: Carneiro, D. F.
name: Freiras, E. A.
name: Gonçalves, B.
name: de Lima, A. G.
name: Shapiro, I. L.
Publisher: name: arXiv
Year: 2004
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Local conformal transformations are known as a useful tool in various applications of the gravitational theory, especially in cosmology. We describe some new aspects of these transformations, in particular using them for derivation of Einstein equations for the cosmological and Schwarzschild metrics. Furthermore, the conformal transformation is applied for the dimensional reduction of the Gauss-Bonnet topological invariant in $d=4$ to the spaces of lower dimensions.
description: 17 pages, LaTeX. Several misprints and mistakes in formulas corrected, one derivation simplified and one reference added
(4050) Elizabeth Lyle
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
First Record of Armina neapolitana (Delle Chiaje, 1824) (Gastropoda: Heterobranchia) in the Sea of Marmara (Turkey)
Creators: name: TUNÇER, Sezginer
name: ARTÜZ, M. Levent
name: ÖNAL, Umur
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2016

description: In August 2015, three specimens of Armina neapolitana were collected from a depth of 64 m in the Sea of Marmara, Turkey. This is the first record of Armina neopolitana, a previously unknown species in Turkish waters.
Impaired Bcl3 Up-regulation Leads to Enhanced Lipopolysaccharide-induced Interleukin (IL)-23P19 Gene Expression in IL-10 –/– Mice
Creators: name: Jobin, Christian
name: Chilton, Paula M.
name: Mitchell, Thomas C.
name: Mühlbauer, Marcus
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Genetic and biochemical analyses show that IL-23p19 plays a central role in mediating bacteria-induced colitis in interleukin-10-deficient (IL-10–/–) mice. The molecular mechanisms responsible for the dysregulated innate host response leading to enhanced IL-23 gene expression in IL-10–/– mice are poorly understood. In this study, we investigated the role of Bcl3 in controlling LPS-induced IL-23p19 gene expression in bone marrow-derived dendritic cells (BMDC) isolated from IL-10–/– mice. We report higher IL-23p19 mRNA accumulation and protein secretion in LPS-stimulated BMDC isolated from IL-10–/– compared with WT mice. Lipopolysaccharide (LPS)-induced B cell leukemia 3 (Bcl3) expression was strongly impaired (90% decrease) in IL-10–/– BMDC compared with WT BMDC. Chromatin immunoprecipitation demonstrated enhanced RelA binding to the IL-23p19 promoter in IL-10–/– compared with WT BMDC. Bcl3 overexpression decreased LPS-induced IL-23p19 gene expression in IL-10–/– BMDC, which correlated with enhanced NF-κB p50 binding and decreased RelA binding to the gene promoter. Conversely, Bcl3 knockdown enhanced LPS-induced IL-23p19 gene expression in WT BMDC. Moreover, LPS-induced IL-23p19 gene expression was significantly enhanced in Bcl3–/– BMDC compared with WT BMDC. In conclusion, enhanced LPS-induced IL-23p19 gene expression in IL-10–/– mice is due to impaired Bcl3 expression leading to diminished p50 and enhanced RelA recruitment to the IL-23p19 promoter.
title: Can superior ophthalmic vein diameter measured from head CT predict intracranial pressure?
Creators: name: Mistry, Vijay
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Haemorrhage
subject: Aneurysms
subject: Puncture
subject: CT-Angiography
subject: CT
subject: Neuroradiology brain
subject: Eyes
subject: Anatomy
subject: Acute

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: The superior ophthalmic vein (SOV) is formed by the union of the supraorbital and angular vein located under the superior rectus muscle, forming the largest of the orbital veins[1]. Unilateral enlargement of the SOV can occur in ocular pathologies...
(4051) Alexander Blair
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
AB-INITIO CALCULATION OF THE RATES OF THE REACTIONS BETWEEN VOLATILE ORGANIC COMPOUNDS IN WINE AND CATIONS FOR MASS SPECTROMETRY
Creators: name: KUMAR, MANJEET
Publisher: name: Universit� degli Studi di Milano
Year: 2020

description: Wine is a complex mixture housing many aroma and flavor compounds giving it a unique texture and bouquet. These volatile organic compounds (VOCs), if present near the sensory threshold limits, may contribute positively to wine quality; however, excessive amounts can detract from quality, and are considered as a fault in wine. It is believed that nearly 10% of the world?s wine is affected from various types of faults. The most common and potent wine taint is 2,4,6-trichloroanisole (2,4,6-TCA), commonly known as cork-taint molecule resulting from the cork stopper of wine bottles. 2,4,6- TCA produces intense ?musty?, ?mouldy? ?earthy? smelling in wine. Similar off-flavor smells are associated to compounds including geosmin and 2-methoxy- 3,5-dimethylpyrazine. We studied 74 such VOCs frequently present in wine. Determining concentration of VOCs in wine requires detection techniques to be fast, in real time, and with a detection limit as low as few parts per trillion by volume. The most frequently used techniques based on direct injection mass spectrometry, namely proton transfer reaction mass spectrometry (PTR-MS) and selected ion flow tube mass spectrometry (SIFT-MS), are being successfully employed in the measurements of VOCs concentrations. Quantification using these techniques usually relies on compound-by-compound instrument calibration. The calibration procedures are generally laborious and time-consuming. The theoretical evaluation of the rate coefficients of ion-molecule reactions occurring in PTR-MS/SIFT-MS flow (drift) tubes is a practical alternative to calibration. In this thesis, we compute and report the rate coefficients for ion-molecule reactions, relevant for different experimental conditions, such as varied temperature and electric fields inside the drift tube. We have used well-established models based on capture cross-section collision and classical trajectories. These models rely on physical properties such as electric dipole moment and polarizability of the volatile molecules. To compute these quantities we resorted to ab initio density functional theory.