cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Model curriculum of the German society for Rheumatology for advanced training in the discipline internal medicine and rheumatology. English version
Creators: name: Pfeil, Alexander
name: Krusche, Martin
name: Vossen, Diana
name: Berliner, Michael N.
name: Keyßer, Gernot
name: Krause, Andreas
name: Lorenz, Hanns-Martin
name: Manger, Bernhard
name: Schuch, Florian
name: Specker, Christof
name: Wollenhaupt, Jürgen
name: Baraliakos, Xenofon
name: Fleck, Martin
name: Proft, Fabian
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: Model training regulations; Core competences; Residency; Further training section; Training institution
subject: 610 Medizin

description: With the implementation of the revision of the model training regulations for German physicians (Musterweiterbildungsverordnung, MWBO) in 2018, the area of each field in internal medicine was redefined and a restructuring of the training period for specialists in internal medicine and rheumatology took place [2].

The minimum training time requires 72 months, divided into two parts of 36 months each, which include both the common contents of the training as a specialist in internal medicine (“basic training”) as well as the specific contents of the specialist training in internal medicine and rheumatology.

The basic training period in “internal medicine” requires acquisition of at least two specialist competences which do not belong to the specializing field. This training consists of 24 months and is complemented by 6 months of training in both an emergency department and an intensive care unit. The specialized training period in internal medicine and rheumatology also extends over 36 months, of which at least 24 months are completed in inpatient rheumatologic care as defined by the MWBO [2]. Exemptions from this regulation were introduced by individual State Medical Chambers (Landesärztekammern) to allow for a longer period of specialized training in outpatient rheumatologic care.

Based on the MWBO of 2018, a model curriculum was developed by the Commission for Education and Training of the German Society of Rheumatology (Deutsche Gesellschaft für Rheumatologie, DGRh) on behalf of the board of the DGRh with regard to core competences in specialized training in internal medicine and rheumatology. This model curriculum focuses on advanced training competences which should be acquired within the 36 months of specialized training in internal medicine and rheumatology and does not include competences relevant to the general part of internal medicine training (basic training).

In this review article, the model curriculum of the DGRh for specialized training in internal medicine and rheumatology is presented.
Feasible route to high-temperature ambient-pressure hydride superconductivity
Creators: name: Dolui, Kapildeb
name: Conway, Lewis J.
name: Heil, Christoph
name: Strobel, Timothy A.
name: Prasankumar, Rohit
name: Pickard, Chris J.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: A key challenge in materials discovery is to find high-temperature superconductors. Hydrogen and hydride materials have long been considered promising materials displaying conventional phonon-mediated superconductivity. However, the high pressures required to stabilize these materials have restricted their application. Here, we present results from high-throughput computation, considering a wide range of high-symmetry ternary hydrides from across the periodic table at ambient pressure. This large composition space is then reduced by considering thermodynamic, dynamic, and magnetic stability, before direct estimations of the superconducting critical temperature. This approach has revealed a metastable ambient-pressure hydride superconductor, Mg$_2$IrH$_6$, with a predicted critical temperature of 160 K, comparable to the highest temperature superconducting cuprates. We propose a synthesis route via a structurally related insulator, Mg$_2$IrH$_7$, which is thermodynamically stable above 15 GPa and discuss the potential challenges in doing so.
description: 30 pages, 30 figures, including SM
Tachygerris adamsoni Drake 1940
Creators: name: Morales-C, Irina T.
name: Castro-Vargas, Maria I.
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Gerridae
Tachygerris
Tachygerris adamsoni

description: Tachygerris adamsoni (Drake, 1940)
Know distribution in Colombia. Casanare and Meta.
Examined material. 3 Ƥ macropterous 1 3 macropterous. Putumayo: Puerto Leguízamo, Caserío Bajo Casacunte, 178m, 19.XI.2008, F. J i m é n e z leg.
description: Published as part of Morales-C, Irina T. & Castro-Vargas, Maria I., 2013, A new species and new records of Tachygerris Drake, 1957 (Hemiptera: Heteroptera: Gerridae) from Colombia, pp. 277-283 in Zootaxa 3616 (3) on page 280, DOI: 10.11646/zootaxa.3616.3.5, http://zenodo.org/record/218038
Agrilus luctator Kerremans
Creators: name: Westcott, Richard L.
name: Hespenheide, Henry A.
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Buprestidae
Agrilus
Agrilus luctator

description: Agrilus luctator Kerremans
ZAC, 2.8 mi S Santa Rosa, Hwy. 54, 9-VII-87, CLBC.
description: Published as part of Westcott, Richard L. & Hespenheide, Henry A., 2006, The description of a new species of Agrilus Curtis, with distributional records, and taxonomic and biological notes for Agrilinae and Trachyinae (Coleoptera: Buprestidae) of Mexico and Central America, pp. 1-35 in Zootaxa 1367 on page 16, DOI: 10.5281/zenodo.273645
IJTIMOIY PROFILAKTIKA: HUQUQIY TARG'IBOT VA MAHALLADA SAMARALI AMALIYOTNI TAMINLAYDI
Creators: name: G'aniyev, Farrux
name: G'aniyeva, Gulandon
name: Rayimqulov, Nodir
Publisher: name: Zenodo
Year: 2024

description: Mazkur maqolada ijtimoiy profilaktikaning huquqiy targ‘ibot va amaliyotdagi o‘rni, uning samarali amalga oshirilishi uchun zarur bo‘lgan shaxslar va tizimlar haqida batafsil tushuntiriladi. Ijtimoiy profilaktika tizimi, asosan, jamiyatda huquqbuzarliklarning oldini olish, ijtimoiy xavfsizlikni ta’minlash, shuningdek, ijtimoiy va huquqiy muammolarni hal qilishga qaratilgan chora-tadbirlar majmui sifatida ko‘rib chiqiladi. Mahalla raislari, profilaktika inspektorlari, hokim yordamchilari, xotin-qizlar faoli va yoshlar etakchisi kabi mas’ul shaxslarning o‘zaro hamkorligi va individual yondashuv asosida amalga oshiriladigan profilaktik ishlar natijasida jamiyatda ijtimoiy barqarorlikni ta’minlashga erishish mumkin. Maqolada ijtimoiy profilaktikaning ob’ektlari, ularni aniqlash va ishlov berish jarayonlari, shuningdek, ijtimoiy moslashtirish dasturlari haqida so‘z boradi. Shu bilan birga, tizimning samaradorligini oshirish va jamiyatdagi xavfsizlikni mustahkamlash uchun zarur bo‘lgan chora-tadbirlar ham muhokama qilinadi.
Tachygerris celocis Drake & Harris 1930
Creators: name: Morales-C, Irina T.
name: Castro-Vargas, Maria I.
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Gerridae
Tachygerris
Tachygerris celocis

description: Tachygerris celocis (Drake & Harris, 1930)
Know distribution in Colombia. Cauca, Caquetá, Casanare, and Meta.
Examined material. Amazonas: 1 Ƥ macropterous 2 3 macropterous. Puerto Nariño, 19.V.2010, I. Morales leg. Boyacá: 1 Ƥ macropterous 2 3 macropterous. San Luis de Gaceno, Vda. El Cairo, 14.IV.2010, I. Morales leg. Chocó: 1 Ƥ macropterous. Lloró, 23.IX.2006, J. Andrade leg. Córdoba: 1 3 macropterous. PNN Paramillo, Tierralta, Sector El Silencio, 8.III.2009, J. Carvajal leg. Putumayo: 7 Ƥ macropterous 5 3 macropterous. Puerto Leguízamo, Caserío Bajo Casacunte, 19.XI.2008, F. Jiménez leg. Vaupés: 1 Ƥ macropterous 1 3 macropterous. Mitú, Comunidad Indígena Acaricuara, Caño Paca, 16.XII.2008, R. Pedroza leg. Mitú, 1 Ƥ macropterous 1 3 macropterous. Comunidad Indígena Acaricuara, 23.VIII.2008, R. Pedroza leg.
description: Published as part of Morales-C, Irina T. & Castro-Vargas, Maria I., 2013, A new species and new records of Tachygerris Drake, 1957 (Hemiptera: Heteroptera: Gerridae) from Colombia, pp. 277-283 in Zootaxa 3616 (3) on page 280, DOI: 10.11646/zootaxa.3616.3.5, http://zenodo.org/record/218038
Agrilus macer LeConte
Creators: name: Westcott, Richard L.
name: Hespenheide, Henry A.
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Buprestidae
Agrilus
Agrilus macer

description: Agrilus macer LeConte
NL, 5 mi S Monterrey, 28-VII-63, CNC (new record, Mexico).
description: Published as part of Westcott, Richard L. & Hespenheide, Henry A., 2006, The description of a new species of Agrilus Curtis, with distributional records, and taxonomic and biological notes for Agrilinae and Trachyinae (Coleoptera: Buprestidae) of Mexico and Central America, pp. 1-35 in Zootaxa 1367 on page 17, DOI: 10.5281/zenodo.273645
Deep learning for nano-photonic materials -- The solution to everything!?
Creators: name: Wiecha, Peter R.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computational Physics (physics.comp-ph)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Deep learning is currently being hyped as an almost magical tool for solving all kinds of difficult problems that computers have not been able to solve in the past. Particularly in the fields of computer vision and natural language processing, spectacular results have been achieved. The hype has now infiltrated several scientific communities. In (nano-)photonics, researchers are trying to apply deep learning to all kinds of forward and inverse problems. A particularly challenging problem is for instance the rational design of nanophotonic materials and devices. In this opinion article, I will first discuss the public expectations of deep learning and give an overview of the quite different scales at which actors from industry and research are operating their deep learning models. I then examine the weaknesses and dangers associated with deep learning. Finally, I'll discuss the key strengths that make this new set of statistical methods so attractive, and review a personal selection of opportunities that shouldn't be missed in the current developments.
description: 13 pages, 7 figures
Passagem entre dois mundos, acesso ao sagrado: sentidos simbólicos da porta barroca no Brasil colonial
Creators: name: S. Oliveira, Carla Mary
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 360102
subject: Art history
classificationCode: 430317
subject: Latin and South American history

description: Paper about Baroque door in colonial Brazil.
Axions and Superfluidity in Weyl Semimetals
Creators: name: Mottola, Emil
name: Sadofyev, Andrey V.
name: Stergiou, Andreas
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: An effective field theory (EFT) for dynamical axions in Weyl semimetals (WSMs) is presented. A pseudoscalar axion excitation is predicted in WSMs at sufficiently low temperatures, independently of the strength of the Weyl fermion self-coupling. For strong fermion self-coupling the axion is the gapless Goldstone boson of chiral $U(1)^{\text{ch}}$ spontaneous symmetry breaking. For weak fermion self-coupling an axion is also generated at non-zero chiral density for Weyl nodes displaced in energy, as a gapless collective mode of correlated fermion pair excitations of the Fermi surface. This is an explicit example of the extension of Goldstone's theorem to symmetry breaking by the axial anomaly itself. In both cases the axion is a chiral density wave or phason mode of the superfluid state of the WSM, and the Weyl fermions form a chiral condensate $\langle\barψψ\rangle$ at low temperatures. In the presence of an applied magnetic field the axion mode becomes gapped, in analogy to the Anderson-Higgs mechanism in a superconductor. 't Hooft anomaly matching from ultraviolet to infrared scales is directly verified in the EFT approach. WSMs thus provide an interesting quantum system in which superfluid, non-Fermi liquid behavior, and a dynamical axion are predicted to follow directly from the axial anomaly in a consistent EFT that may be tested experimentally.
description: 51 pages, 7 figures. v2: Minor emendations, references added. Published version
Tachygerris opacus Champion 1898
Creators: name: Morales-C, Irina T.
name: Castro-Vargas, Maria I.
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Gerridae
Tachygerris
Tachygerris opacus

description: Tachygerris opacus (Champion, 1898)
Know distribution in Colombia. Caquetá, Casanare, Cauca, Cesar, Córdoba, Magdalena, Meta, Norte de Santander, Quindío, Risaralda, Tolima, Valle del Cauca, and Vaupés.
Examined material. Amazonas: 4 Ƥ macropterous 3 3 macropterous. Puerto Nariño, 19.V. 2010, I. Morales leg. Arauca: 2 Ƥ macropterous 2 3 macropterous. Tame, Vda. Brisas del Cravo, 25.XI.2007, F. Alvarado leg. Boyacá: 1 3 macropterous Santa María, 31.X.2008, I. Morales leg. 1 Ƥ macropterous 2 3 macropterous. San Luis de Gaceno, Vda. El Cairo, 14.IV.2010, I. Morales leg. 1 Ƥ macropterous 2 3 macropterous. Chocó: 2 3 macropterous. Acandí, Capurganá, Sapzurro, 20.I.2008, J. López leg. 4 Ƥ macropterous 4 3 macropterous. Acandí, Capurganá, Jardín Botánico, 16. I.2008, F. Molano leg. 4 Ƥ macropterous 5 3 macropterous. Acandí, Capurganá, Bocatoma, 17.I.2008, A. Estupiñan leg. 9 3 macropterous 10 Ƥ macropterous. Acandí, Capurganá, Sapzurro, 15.I.2008, A. Estupiñan leg.
description: Published as part of Morales-C, Irina T. & Castro-Vargas, Maria I., 2013, A new species and new records of Tachygerris Drake, 1957 (Hemiptera: Heteroptera: Gerridae) from Colombia, pp. 277-283 in Zootaxa 3616 (3) on page 281, DOI: 10.11646/zootaxa.3616.3.5, http://zenodo.org/record/218038
Agrilus major Waterhouse
Creators: name: Westcott, Richard L.
name: Hespenheide, Henry A.
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Buprestidae
Agrilus
Agrilus major

description: Agrilus major Waterhouse
JAL, Chapala, 15-VIII-49, CNC; MEX, 10.5 km NE Zuluapán, 1276 m, 23-VIII-91; OAX, 26 km N Putla, Hwy. 125, 26-X-90, CLBC; La Escondida, Rt. 190, km. 727, 11- VII-66, USNM.
description: Published as part of Westcott, Richard L. & Hespenheide, Henry A., 2006, The description of a new species of Agrilus Curtis, with distributional records, and taxonomic and biological notes for Agrilinae and Trachyinae (Coleoptera: Buprestidae) of Mexico and Central America, pp. 1-35 in Zootaxa 1367 on page 17, DOI: 10.5281/zenodo.273645
Secular Outflows from Long-Lived Neutron Star Merger Remnants
Creators: name: Radice, David
name: Bernuzzi, Sebastiano
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We study mass ejection from a binary neutron star merger producing a long-lived massive neutron star remnant with general-relativistic neutrino-radiation hydrodynamics simulations. In addition to outflows generated by shocks and tidal torques during and shortly after the merger, we observe the appearance of a wind driven by spiral density waves in the disk. This spiral-wave-driven outflow is predominantly located close to the disk orbital plane and have a broad distribution of electron fractions. At higher latitudes, a high electron-fraction wind is driven by neutrino radiation. The combined nucleosynthesis yields from all the ejecta components is in good agreement with Solar abundance measurements.
description: 9 pages, 5 figures. Submitted to ASTRONUM2023 proceedings
Integrating structure-guided and fragment-based inhibitor design to combat bedaquiline resistant Mycobacterium tuberculosis: a molecular dynamics study
Creators: name: Roy, Alankar
name: Banerjee, Prantik
name: Paul, Ishani
name: Ghosh, Ritam
name: Ray, Sujay
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Cancer

description: The first FDA approved, MDR-TB inhibitory drug bedaquiline (BDQ), entraps the c-ring of the proton-translocating F0 region of enzyme ATP synthase of Mycobacterium tuberculosis, thus obstructing successive ATP production. Present-day BDQ-resistance has been associated with cardiotoxicity and mutation(s) in the atpE gene encoding the c subunit of ATP synthase (ATPc) generating five distinct ATPc mutants: Ala63→Pro, Ile66→Met, Asp28→Gly, Asp28→Val and Glu61→Asp. We created three discrete libraries, first by repurposing bedaquiline via scaffold hopping approach, second one having natural plant compounds and the third being experimentally derived analogues of BDQ to identify one drug candidate that can inhibit ATPc activity more efficiently with less toxic properties. For this purpose, we adopted techniques like molecular dynamics simulation, virtual screening, PCA, DCCM, binding affinity analysis to gauge structure-function relationship of the L136-ATPc complexes. L136 was found to induce a distinguishable conformational change in the bound ATPc which captivated the c9 rotor ring. L136 displays a binding free energy of −57.294, −59.027, −57.273, −58.726, −55.889 and −58.651 kcal/mol for ATPc_WT and the five respective mutants. The pIC50 value for the L136 ligand for the same proteins was unveiled to be 6.760, 7.285, 6.898, 7.222, 6.987 and 7.687. Moreover, L136 exhibited a strong ADMET profile. Furthermore, we discovered that the change in the hydrophobic platform in ATPc mutants hinders BDQ binding, which is overcome by L136, ensuring efficient binding and providing an assessment of L136’s mechanism of ATPc inhibition. L136 provides a scope for in vivo test for future clinical drug trials.
Agrilus malvastri Fisher
Creators: name: Westcott, Richard L.
name: Hespenheide, Henry A.
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Buprestidae
Agrilus
Agrilus malvastri

description: Agrilus malvastri Fisher
DGO, 2 mi S La Zarca, 16-VII-64, EMEC; ZAC, 4 mi NE Concepción de Oro, 4-VII-84, TAMU (new record, Mexico).
description: Published as part of Westcott, Richard L. & Hespenheide, Henry A., 2006, The description of a new species of Agrilus Curtis, with distributional records, and taxonomic and biological notes for Agrilinae and Trachyinae (Coleoptera: Buprestidae) of Mexico and Central America, pp. 1-35 in Zootaxa 1367 on page 17, DOI: 10.5281/zenodo.273645
Immunity after COVID-19 and vaccination: follow-up study over 1 year among medical personnel
Creators: name: Glück, Vivian
name: Grobecker, Sonja
name: Köstler, Josef
name: Tydykov, Leonid
name: Bertok, Manuela
name: Weidlich, Tanja
name: Gottwald, Christine
name: Salzberger, Bernd
name: Wagner, Ralf
name: Zeman, Florian
name: Koller, Michael
name: Gessner, Andre
name: Schmidt, Barbara
name: Glück, Thomas
name: Peterhoff, David
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: SARS-COV-2; COVID-19; SARS-CoV-2; Cellular immunity; Antibody-mediated immunity; SARS-CoV-2-vaccination
subject: 610 Medizin

description: Background The long-term course of immunity among individuals with a history of COVID-19, in particular among those who received a booster vaccination, has not been well defined so far. Methods SARS-CoV-2-specific antibody levels were measured by ELISA over 1 year among 136 health care workers infected during the first COVID-19 wave and in a subgroup after booster vaccination approximately 1 year later. Furthermore, spike-protein-reactive memory T cells were quantified approximately 7 months after the infection and after booster vaccination. Thirty healthy individuals without history of COVID-19 who were routinely vaccinated served as controls. Results Levels of SARS-CoV-2-specific IgM- and IgA-antibodies showed a rapid decay over time, whereas IgG-antibody levels decreased more slowly. Among individuals with history of COVID-19, booster vaccination induced very high IgG- and to a lesser degree IgA-antibodies. Antibody levels were significantly higher after booster vaccination than after recovery from COVID-19. After vaccination with a two-dose schedule, healthy control subjects developed similar antibody levels as compared to individuals with history of COVID-19 and booster vaccination. SARS-CoV-2-specific memory T cell counts did not correlate with antibody levels. None of the study participants suffered from a reinfection. Conclusions Booster vaccination induces high antibody levels in individuals with a history of COVID-19 that exceeds by far levels observed after recovery. SARS-CoV-2-specific antibody levels of similar magnitude were achieved in healthy, COVID-19-naive individuals after routine two-dose vaccination.
Moving beyond conventional resistance and resistors: an integrative review of employee resistance to digital transformation
Creators: name: Cieslak, Veronika
name: Valor, Carmen
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Plant Biology
subject: FOS: Biological sciences

description: Despite widespread organizational interest in digital technologies (DT), digital transformation projects often fail largely due to employee resistance. However, research on this resistance is fragmented and lacks integration, providing only partial explanations of the phenomenon. To address this gap, this integrative review aims to identify barriers to DT adoption in the workplace. Sixty-three papers met the eligibility criteria and underwent rigorous analysis. The factors thus identified reveal that resistance originates from workers’ perceived job vulnerability. This explanation, however, is limited because of the assumptions it makes concerning the functions of technologies and the resources provided by jobs. By shifting the conceptualization of digital technologies from neutral tools to agents with causal powers and acknowledging the multifaceted nature of job resources, this review proposes a reconceptualization of resistance. Drawing from theories of social conflict, it integrates previous work to develop a three-stage model of resistance that reflects how perceived threats to resources influence employees’ perceptions, emotional responses, and subsequent actions in the workplace. Building on this model, we propose a comprehensive framework that uses four pathways to explain how resistance may unfold in the workplace. Furthermore, we propose several research directions to guide future investigations. In light of these findings, this integrative review also presents various theoretical and managerial implications.
Asymptotic Normality and Finite-Sample Robustness of the Fourier Spot Volatility Estimator in the Presence of Microstructure Noise
Creators: name: Mancino, Maria Elvira
name: Mariotti, Tommaso
name: Toscano, Giacomo
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Physical Sciences not elsewhere classified
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Mathematical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: We study the efficiency and robustness of the Fourier spot volatility estimator when high-frequency prices are contaminated by microstructure noise. First, we show that the estimator is consistent and asymptotically efficient in the presence of additive noise, establishing a Central Limit Theorem (CLT) with the optimal rate of convergence n1/8. Additionally, we complete the asymptotic theory in the absence of noise, obtaining a CLT with the optimal rate of convergence n1/4. Feasible CLTs with the optimal convergence rate are also obtained, by proving the consistency of the Fourier estimators of the spot volatility of volatility and the quarticity in the presence of noise. Second, we introduce a feasible method for selecting the cutting frequencies of the estimator in the presence of noise, based on the optimization of the integrated asymptotic variance. Finally, we provide support to the accuracy and robustness of the method by means of a numerical study and an empirical exercise, which is conducted using tick-by-tick prices of three U.S. stocks with different liquidity.
Naturally sterile Mus spretus hybrids are suitable for the generation of pseudopregnant embryo transfer recipients.
Creators: name: Preece, Chris
name: Biggs, Daniel
name: Grencis, Edward
name: Jackson, Maj Simonsen
name: Allen, Sue
name: Fray, Martin
name: Adamson, Antony
name: Davies, Benjamin
Publisher: name: The Francis Crick Institute
Year: 2024
Subjects: classificationCode: Model organisms
subject: Model organisms
classificationCode: Genetics & Genomics
subject: Genetics & Genomics
classificationCode: Imaging
subject: Imaging

description: For the preparation of embryo transfer recipients, surgically vasectomized mice are commonly used, generated by procedures associated with pain and discomfort. Sterile transgenic strains provide a nonsurgical replacement, but their maintenance requires breeding and genotyping procedures. We have previously reported the use of naturally sterile STUSB6F1 hybrids for the production of embryo transfer recipients and found the behavior of these recipients to be indistinguishable from those generated by vasectomized males. The method provides two substantial 3R impacts: refinement (when compared with surgical vasectomy) and reduction in breeding procedures (compared with sterile transgenic lines). Despite initial promise, the 3Rs impact of this innovation was limited by difficulties in breeding the parental STUS/Fore strain, which precluded the wider distribution of the sterile hybrid. The value of a 3R initiative is only as good as the uptake in the community. Here we, thus, select a different naturally sterile hybrid, generated from strains that are widely available: the B6SPRTF1 hybrid between C57BL/6J and Mus spretus. We first confirmed its sterility by sperm counting and testes weight and then trialed the recovery of cryopreserved embryos and germplasm within three UK facilities. Distribution of sperm for the generation of these hybrids by in vitro fertilization was found to be the most robust distribution method and avoided the need to maintain a live M. spretus colony. We then tested the suitability of B6SPRTF1 sterile hybrids for the generation of embryo transfer recipients at these same three UK facilities and found the hybrids to be suitable when compared with surgical vasectomized mice and a sterile transgenic strain. In conclusion, the potential 3Rs impact of this method was confirmed by the ease of distribution and the utility of sterile B6SPRTF1 hybrids at independent production facilities.
Asymptotic normality and finite-sample robustness of the Fourier spot volatility estimator in the presence of microstructure noise
Creators: name: Mancino, Maria Elvira
name: Mariotti, Tommaso
name: Toscano, Giacomo
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Physical Sciences not elsewhere classified
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Mathematical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: We study the efficiency and robustness of the Fourier spot volatility estimator by Malliavin and Mancino [2002] when high-frequency prices are contaminated by microstructure noise. Firstly, we show that the estimator is consistent and asymptotically efficient in the presence of additive noise, establishing a Central Limit Theorem (CLT) with the optimal rate of convergence n1/8. Additionally, we complete the asymptotic theory proved by Mancino and Recchioni [2015] in the absence of noise, obtaining a CLT with the optimal rate of convergence n1/4. Feasible CLTs with the optimal convergence rate are also obtained, by proving the consistency of the Fourier estimators of the spot volatility of volatility and the quarticity in the presence of noise. Secondly, we introduce a feasible method for selecting the cutting frequencies of the estimator in the presence of noise, based on the optimization of the integrated asymptotic variance. Finally, we provide support to the accuracy and robustness of the method by means of a numerical study and an empirical exercise, which is conducted using tick-by-tick prices of three US stocks with different liquidity.
Implant-based immediate reconstruction in prophylactic mastectomy: is the caudal dermis flap a reliable alternative to synthetic mesh or acellular dermal matrix?
Creators: name: Heine, Norbert
name: Hoesl, Vanessa
name: Seitz, Stephan
name: Prantl, Lukas
name: Brebant, Vanessa
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: NIPPLE-SPARING MASTECTOMY; SKIN-REDUCING MASTECTOMY; BREAST RECONSTRUCTION; AMERICAN SOCIETY; OUTCOMES; TISSUE; Caudal dermis flap; mastectomy; breast reconstruction; macromastia; ptosis
subject: 610 Medizin

description: Introduction The demand for prophylactic mastectomy has increased significantly over the last 10 years. This can be explained by a substantial gain of knowledge about the clinical risk and outcome of patients with high risk mutations such as BRCA1 and 2, the improved diagnostic possibilities for detecting the genetic predisposition for the development of breast cancer and the awareness for those mutations by health care professionals as well as patients. In addition to expander-to-implant reconstruction and microsurgical flap surgery, definitive immediate reconstruction with subpectoral insertion of breast implants is often preferred. The prosthesis is covered at its inferior pole by a synthetic mesh or acellular dermal matrix. In these cases, in addition to the silicone prosthesis, a further foreign body must be implanted. This can be exposed in the event of wound healing disorder or necrosis of the usually thin soft tissue covering after subcutaneous mastectomy, thus calling into question the reconstructive result. In this study, the coverage of the lower pole by a caudal deepithelialized dermis flap, which allows the implant to be completely covered with well vascularized tissue, is compared to coverage by a synthetic mesh or acellular dermal matrix. Patients and methods From January 2014 to June 2020, 74 patients (106 breasts) underwent breast reconstruction following uni or bilateral prophylactic mastectomy. Reconstruction was performed with autologous tissue (15 breasts), with tissue expander or implant without implant support (15 breasts), with implant and use of an acellular dermal matrix or synthetic mesh (39 breasts) and with implant and caudal dermis flap (37 breasts). In this study, we compared the patients with implant and dermal matrix/mesh to the group reconstructed with implant and dermal flap. Results In the group with the caudal dermis flap, 4 patients developed skin necrosis, which all healed conservatively due to the sufficient blood supply through the dermis flap. In the group with the use of a synthetic mesh or acellular dermal matrix, skin necrosis was found in three cases. In one of these patients the implant was exposed and had to be removed. Discussion For patients with excess skin or macromastia, the caudal dermis flap is a reliable and less expensive option for complete coverage of an implant after prophylactic mastectomy. In particular, the vascularized dermis flap can protect the implant from the consequences of skin necrosis after prophylactic mastectomy.
THE SIGNIFICANCE OF ART PEDAGOGY IN DEVELOPING ARTISTIC AND AESTHETIC COMPETENCE
Creators: name: Askarov, Bekhzod
Publisher: name: Zenodo
Year: 2024

description: This article explores the role and significance of art pedagogy in developing artistic-aesthetic competence among preschool educators. Artistic-aesthetic competence is crucial in shaping individuals' creative thinking, aesthetic taste, and cultural appreciation of art. The study employs theoretical analysis, empirical research, and experimental approaches to evaluate the effectiveness of art pedagogy tools in educational processes. Results demonstrate that art pedagogy significantly enhances educators' abilities to integrate artistic methods, fostering students' creativity and aesthetic values. The paper also highlights challenges such as resource limitations and the necessity for professional development programs. Recommendations for broader application of art pedagogy in education are provided.
SGLT2 Inhibitors and Their Mode of Action in Heart Failure—Has the Mystery Been Unravelled?
Creators: name: Pabel, Steffen
name: Hamdani, Nazha
name: Luedde, Mark
name: Sossalla, Samuel
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: SGLT2 inhibitors, Heart failure, HFrEF, HFpEF
subject: 610 Medizin

description: Purpose of review
SGLT2 inhibitors (SGLT2i) are new drugs for patients with heart failure (HF) irrespective of diabetes. However, the mechanisms of SGLT2i in HF remain elusive. This article discusses the current clinical evidence for using SGLT2i in different types of heart failure and provides an overview about the possible underlying mechanisms.
Recent findings
Clinical and basic data strongly support and extend the use of SGLT2i in HF. Improvement of conventional secondary risk factors is unlikely to explain the prognostic benefits of these drugs in HF. However, different multidirectional mechanisms of SGLT2i could improve HF status including volume regulation, cardiorenal mechanisms, metabolic effects, improved cardiac remodelling, direct effects on cardiac contractility and ion-homeostasis, reduction of inflammation and oxidative stress as well as an impact on autophagy and adipokines.
Summary
Further translational studies are needed to determine the mechanisms of SGLT2i in HF. However, basic and clinical evidence encourage the use of SGLT2i in HFrEF and possibly HFpEF.
Shedding light on the MiniBoone Excess with Searches at the LHC
Creators: name: Herwig, Christian
name: Isaacson, Joshua
name: Jayatilaka, Bo
name: Machado, Pedro A. N.
name: Hall, Allie Reinsvold
name: Safdari, Murtaza
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The origin of the excess of low-energy events observed by the MiniBooNE experiment remains a mystery, despite exhaustive investigations of backgrounds and a series of null measurements from complementary experiments. One intriguing explanation is the production of beyond-the-Standard-Model particles that could mimic the experimental signature of additional $ν_e$ appearance seen in MiniBooNE. In one proposed mechanism, muon neutrinos up-scatter to produce a new ``dark neutrino'' state that decays by emitting highly-collimated electron-positron pairs. We propose high-energy neutrinos produced from $W$ boson decays at the Large Hadron Collider as an ideal laboratory to study such models. Simple searches for a low-mass, boosted di-lepton resonance produced in association with a high-$p_\text{T}$ muon from the $W$ decay with Run 2 data would already provide unique sensitivity to a range of dark neutrino scenarios, with prompt and displaced searches providing complementarity. Looking farther ahead, we show how the unprecedented sample of $W$ boson decays anticipated at the HL-LHC, together with improved lepton acceptance would explore much of the parameter space most compatible with the MiniBooNE excess.
description: 16 pages, 9 figures
title: Working Together to Mint DOIs on Demand for a DSpace Repository
Creators: name: Grynoch, Catherine Tess
name: Palmer, Lisa
Publisher: name: UMass Chan Medical School
Year: 2024

description: Background: Digital Object Identifiers (DOIs) are a key persistent identifier in the publishing landscape to ensure discoverability and citation of research products. Minting DOIs can be a time-consuming task for repository librarians. This process can be automated since the metadata for DOIs is already in the repository record and DataCite, a DOI minting organization, and Open Repository, a DSpace repository platform, both have application programming interfaces (APIs). Previous software has enabled bulk DOI minting. However, the institutional repository contains a mixture of original materials (dissertations, reports, data, etc.) and previously published materials such as journal articles and preprints. 
Description: An institutional repository librarian and her librarian colleague with Python experience embarked on a pair programming project to create a script to mint DOIs on demand in DataCite for individual items in the institution’s Open Repository instance. The pair met for one hour each week to develop and test the script. The institutional repository librarian lent invaluable insight into both platforms and the metadata variations the code would need to account for. The project was also a great learning opportunity for both librarians to improve their Python coding skills. This project will be evaluated in terms of how the time spent creating the code compares to the time it takes to mint DOIs manually as well as metadata enhancements and accuracy in DataCite.
Program Conclusion: This poster will share the final Python script and highlight the takeaways from this approach for both the institutional repository librarian and the coding librarian. Final evaluation is forthcoming.
High efficiency and stable perovskite photovoltaics via interface engineering
Creators: name: Perera, Withanage Hashini Kawshika
Publisher: name: University of Surrey
Year: 2024
Subjects: Perovskites
Clean Energy
Climate Action
Photovoltaics
Renewable Energy
Sustainability

description: Metal halide perovskites have shown a tremendous progress over the last decade with single junction efficiencies now showing parity with the incumbent silicon technologies for laboratory scale devices. Recent efforts have focused on the translation of these performances to large areas. However, to be competitive with silicon photovoltaics, there is a need for improvement in device stability. As a result, the modification of the top surface of the perovskite absorber and the metal electrode is being investigated in detail. Other than the above, the buried interface of a perovskite solar cell can influence the device stability, by driving chemical reactions at the interface and influencing the compositional homogeneity of the perovskite bulk. This thesis focuses on developing an understanding at a fundamental level, the influence of the buried interface on performance losses in inverted perovskite solar cells (PSCs), and to devise strategies to realise high efficiencies and improved stability via interface engineering. Firstly, the origin of performance loss in inverted PSCs based on poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) as the hole transport material is investigated. This is carried out through careful analysis of the chemical interactions between the constituents in the perovskite precursor and PEDOT:PSS as well through compositional evaluation of the buried PEDOT:PSS layer. Based on the understanding developed, a lead-tin PSC with improved power conversion efficiency of 23.2% and ~66% improved device lifetime is realised through additive engineering. Following this, the wettability challenge of perovskite precursors on the hydrophobic self-assembled monolayer [4-(3,6-Dimethyl-9H-carbazol-9-yl)butyl]phosphonic Acid (Me-4PACz) is evaluated. Alumina nanoparticle-based modification of Me-4PACz is identified as a solution that not only improves the perovskite wettability and thereby device reproducibility, but also results in enhanced carrier lifetimes and high device efficiencies. The influence of the alumina nanoparticles on device stability is investigated where significant improvements in device lifetimes are observed when degraded under ambient conditions at 65 °C in the dark. The origins underlying the improved device lifetime are identified as the efficient scavenging of iodine, improved bulk electrical and surface electronic homogeneity due to the underlying alumina nanoparticle layer. This thesis highlights the importance of the buried interface in realising high efficiency PSCs through additive engineering to the perovskite bulk and nanoengineering of the buried interface. The design guidelines introduced are applicable not only to single junction devices, but also to multijunction architectures.
MPEC 2025-A125 : 2025 AL2
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2025
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2025 AL2

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Generative-Model-Based Fully 3D PET Image Reconstruction by Conditional Diffusion Sampling
Creators: name: Webber, George
name: Mizuno, Yuya
name: Howes, Oliver D.
name: Hammers, Alexander
name: King, Andrew P.
name: Reader, Andrew J.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Medical Physics (physics.med-ph)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Machine Learning (cs.LG)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Score-based generative models (SGMs) have recently shown promising results for image reconstruction on simulated positron emission tomography (PET) datasets. In this work we have developed and implemented practical methodology for 3D image reconstruction with SGMs, and perform (to our knowledge) the first SGM-based reconstruction of real fully 3D PET data. We train an SGM on full-count reference brain images, and extend methodology to allow SGM-based reconstructions at very low counts (1% of original, to simulate low-dose or short-duration scanning). We then perform reconstructions for multiple independent realisations of 1% count data, allowing us to analyse the bias and variance characteristics of the method. We sample from the learned posterior distribution of the generative algorithm to calculate uncertainty images for our reconstructions. We evaluate the method's performance on real full- and low-count PET data and compare with conventional OSEM and MAP-EM baselines, showing that our SGM-based low-count reconstructions match full-dose reconstructions more closely and in a bias-variance trade-off comparison, our SGM-reconstructed images have lower variance than existing baselines. Future work will compare to supervised deep-learned methods, with other avenues for investigation including how data conditioning affects the SGM's posterior distribution and the algorithm's performance with different tracers.
description: 2 pages, 2 figures. Accepted for oral presentation at IEEE NSS MIC RTSD 2024 (submitted May 2024; accepted July 2024; presented Nov 2024)
Machine Learning Classification of Sphalerons and Black Holes at the LHC
Creators: name: Grefsrud, Aurora Singstad
name: Buanes, Trygve
name: Koutroulis, Fotis
name: Lipniacka, Anna
name: Masełek, Rafał
name: Papaefstathiou, Andreas
name: Sakurai, Kazuki
name: Sjursen, Therese B.
name: Slazyk, Igor
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: In models with large extra dimensions, "miniature" black holes (BHs) might be produced in high-energy proton-proton collisions at the Large Hadron Collider (LHC). In the semi-classical regime, those BHs thermally decay, giving rise to large-multiplicity final states with jets and leptons. On the other hand, similar final states are also expected in the production of electroweak sphaleron/instanton-induced processes. We investigate whether one can discriminate these scenarios when BH or sphaleron-like events are observed in the LHC using machine learning (ML) methods. Classification among several BH scenarios with different numbers of extra dimensions and the minimal BH masses is also examined. In this study we consider three ML models: XGBoost algorithms with (1) high- and (2) low-level inputs, and (3) a Residual Convolutional Neural Network. In the latter case, the low-level detector information is converted into an input format of three-layer binned event images, where the value of each bin corresponds to the energy deposited in various detector subsystems. We demonstrate that only a small number of detected events are sufficient to effectively discriminate between the sphaleron and BH processes. Separation between BH scenarios with different minimal masses is possible with an order of 10 events passing the preselection. A sufficient number of events could be observed in combined Run-2 and -3 data, if the production cross section is not much smaller than the present limit ~ 0.1 fb. We find, however, that a large number of events is needed to discriminate between BH hypotheses with the same minimal BH mass, but different numbers of extra dimensions.
description: 20 pages, 5 figures, the version published in EPJC
Young people's desires and attempts to stop smoking - 2014
Creators: name: White, Joanna
Publisher: name: Health New Zealand
Year: 2024
Subjects: classificationCode: 420603
subject: Health promotion

description: The Health Promotion Agency’s (HPA’s) Youth Insights Survey (YIS) monitors Year 10 students’ behaviours, attitudes and knowledge on a range of tobacco-related topics, including about their desires and attempts to stop smoking, and has collected this data since 2006. This fact sheet focuses on young people’s desires and attempts to stop smoking between 2006 and 2014.