Additional file 1 of Oxygenation index in the first three weeks of life is a predictor of bronchopulmonary dysplasia grade in very preterm infants
Creators: name: Chou, Fu-Sheng
name: Leigh, Rebekah M.
name: Rao, Srinandini S.
name: Narang, Arvind
name: Yeh, Hung-Wen
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 1: Supplemental Figure 1. Boxplots depicting the distribution of oxygenation index data points for each day of life on (A) a linear or (B) a logarithmic (log) scale. The thick horizontal lines represent median, the upper and lower hinges of the boxes represent the 75th and 25th percentiles, and the whiskers extend from the hinges to the largest value no further than 1.5 times the interquartile range. Dots represent outliers. Supplemental Figure 2. Oxygenation index trajectory estimates over the first three weeks of life after logarithmic transformation using generalized additive mixed modeling (solid line) or generalized additive modeling (dotted line). The red lines represent trajectory estimates. The shades represent the standard error of the trajectory estimates. The grey dots represent the raw OI values at the indicated time points. The raw OI values for each individual infant were connected by a line. The logarithmic scale is shown on the left Y-axis, and the linear scale on the right. Supplemental Figure 3. Oxygenation index (OI) trajectory estimates over the first three weeks of life after logarithmic transformation using generalized additive mixed modeling. The input data contained either all infants with at least one OI data point (red, n=254), or infants with average OI values in more than one DOL/24-hr interval (blue, n=242). The corresponding shades represent standard error of the trajectory estimates. The logarithmic scale is shown on the left Y-axis, and the linear scale on the right. Not that the two trajectory curves are nearly identical, indicating that including or excluding infants contributing data points only within one DOL/24-hr interval does not significantly alter trajectory estimates. Supplemental Figure 4. Oxygenation index (OI) trajectory estimates over the first three weeks of life after logarithmic transformation using generalized additive mixed modeling (GAMM) with and without missing value imputation. Red curves represent trajectory estimates using all available OI data points based on the assumption that the missing OI values were missing at random. Blue solid curves are trajectory estimates modeled using data from a subset of infants who had OI data points at the end of the three weeks of life, representing the worst-case scenario. Blue dashed lines are trajectory estimates modeled using all available OI data points plus imputed data by taking the lowest observed OI value for each infant, representing the best-case scenario in which arterial blood gas was no longer required as a result of stable respiratory status (missing not at random). Shades represent standard error of the trajectory estimates. Supplemental Figure 5. Multinomial multivariable regression analysis of BPD grades. Forest plots showing odds ratio and 95% confidence interval (CI) for each of the indicated variables after adjusting for the others. Note that the duration of invasive ventilation (DurationINV) in the first three weeks of life significantly correlated with BPD grade in each of the pairwise comparison after adjusting for gestational age (GA), birth weight z-score (BW-Z), and sex. Supplemental Figure 6. Multinomial multivariable regression analysis of BPD grade. Forest plots showing odds ratio (OI) and 95% confidence interval (CI) for each of the indicated variables after adjusting for the others. Note that the odds ratios for the initial OI and the average daily OI change (ΔOIAVG) remained significant after adjusting for gestational age (GA), brith weight z-score (BW-A), and sex with and without additional adjusting by the duration of invasive ventilation (DurationINV). GA. Supplemental Table 1. Cause of death. Supplemental Table 2. Multinomial regression model comparison using Akaike information criteria (AIC).