cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Development of a multi-targeted chemotherapeutic approach based on G-quadruplex stabilisation and carbonic anhydrase inhibition
Creators: name: Nocentini, Alessio
name: Di Porzio, Anna
name: Bonardi, Alessandro
name: Bazzicalupi, Carla
name: Petreni, Andrea
name: Biver, Tarita
name: Bua, Silvia
name: Marzano, Simona
name: Amato, Jussara
name: Pagano, Bruno
name: Iaccarino, Nunzia
name: De Tito, Stefano
name: Amente, Stefano
name: Supuran, Claudiu T.
name: Randazzo, Antonio
name: Gratteri, Paola
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: A novel class of compounds designed to hit two anti-tumour targets, G-quadruplex structures and human carbonic anhydrases (hCAs) IX and XII is proposed. The induction/stabilisation of G-quadruplex structures by small molecules has emerged as an anticancer strategy, disrupting telomere maintenance and reducing oncogene expression. hCAs IX and XII are well-established anti-tumour targets, upregulated in many hypoxic tumours and contributing to metastasis. The ligands reported feature a berberine G-quadruplex stabiliser scaffold connected to a moiety inhibiting hCAs IX and XII. In vitro experiments showed that our compounds selectively stabilise G-quadruplex structures and inhibit hCAs IX and XII. The crystal structure of a telomeric G-quadruplex in complex with one of these ligands was obtained, shedding light on the ligand/target interaction mode. The most promising ligands showed significant cytotoxicity against CA IX-positive HeLa cancer cells in hypoxia, and the ability to stabilise G-quadruplexes within tumour cells.
MOESM1 of A Bayesian inference method for the analysis of transcriptional regulatory networks in metagenomic data
Creators: name: Hobbs, Elizabeth
name: Talmo Pereira
name: OâNeill, Patrick
name: Erill, Ivan
Publisher: name: Figshare
Year: 2016
Subjects: subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Computational Biology

description: Additional file 1. Appendix. Derivation of the soft-max scoring function.
Campanithrips Ulitzka, 2024, gen. n.
Creators: name: Ulitzka, Manfred R.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Thysanoptera
Stenurothripidae
Campanithrips

description: Campanithrips gen. n.
Type species. Campanithrips kyakhei gen. et sp. n.
Diagnosis. Head with eyes protruding over the base of antennae. Antennae nine-segmented with the distal segments fully distinct from each other; segment III distally with broad sense cone (sensoria not visible on IV). Setae on head and pronotum not assessable (at least some longer posteromarginal or posteroangular setae present). Mouth cone short and rounded. Fore wings with softly pointed tips; hind and front margin with straight wing fringes; costal setae long, about as long as wing width in the middle; both longitudinal veins complete but with a slightly larger gap between the penultimate and the distal seta; with two (visible) cross veins. Fore wing surface with microtrichia. Fore femora slender; fore tarsi with hamus.
Based on the above-mentioned character states of the fore wings and the broad sense cones Campanithrips gen. n. is attributed to Stenurothripidae (see Bhatti 2006). At present, this family comprises ten fossil and three extant genera (Mound & Hastenpflug-Vesmanis 2021). Campanithrips gen. n. differs from all fossil genera by the straight fringes on the hind margin of the fore wings (Schliephake 1990, p. 180; Peñalver & Nel 2010; Tong et al. 2019; Guo et al. 2024) and is thus more similar to extant forms. Compared with extant Holarthrothrips Bagnall and Oligothrips Moulton the new genus has less setae on the wing veins, but these are much longer and stronger than in Heratythrips Mound & Marullo.
Etymology. The name Campanithrips gen. n. refers to the Campanian origin of amber and is combined with -thrips, the usual term for a genus within Thysanoptera.
description: Published as part of Ulitzka, Manfred R., 2024, Late Cretaceous thrips (Thysanoptera) from Hti Lin amber, pp. 99-106 in Zootaxa 5489 (1) on pages 102-103, DOI: 10.11646/zootaxa.5489.1.6, http://zenodo.org/record/13211257
MOESM8 of â  Gap huntingâ   to characterize clustered probe signals in Illumina methylation array data
Creators: name: Andrews, Shan
name: Ladd-Acosta, Christine
name: Feinberg, Andrew
name: Hansen, Kasper
name: M. Fallin
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 8: Figure S33. MAF distributions of measured SNPs vs annotated SNPs that map to 450k probes. We calculated the minor allele frequency (MAF) of all measured SNPs that mapped to gap signals, and determined the MAF for all of the annotated SNPs that map to gap signals as seen in the dbSNP138 annotation. The greater amount of SNPs with high MAF (>0.1) in the annotated SNP group may account for the higher area under the curve at higher standard deviation values as seen in Fig.Â 8.
Vitamin B6 inhibits activity of Helicobacter pylori adenylosuccinate synthetase and growth of reference and clinical, antibiotic-resistant H. pylori strains
Creators: name: Wojtyś, Marta Ilona
name: Maksymiuk, Weronika
name: Narczyk, Marta
name: Bubić, Ante
name: Ašler, Ivana Leščić
name: Krzyżek, Paweł
name: Gościniak, Grażyna
name: Jagusztyn-Krynicka, Elżbieta Katarzyna
name: Bzowska, Agnieszka
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: The current therapies against gastric pathogen Helicobacter pylori are ineffective in over 20% of patients. Enzymes belonging to the purine salvage pathway are considered as novel drug targets in this pathogen. Therefore, the main aim of the current study was to determine the antibacterial activity of pyridoxal 5’-phosphate (PLP), an active form of vitamin B6, against reference and clinical strains of H. pylori. Using a broad set of microbiological, physicochemical (UV absorption, LC-MS, X-ray analysis) and in silico experiments, we were able to prove that PLP inhibits adenylosuccinate synthetase (AdSS) from H. pylori by the competition with GTP (IC50eq ∼30 nM). This behaviour was attributed to formation of a Schiff base with a lysine residue (a covalent bond with Lys322 in the GTP binding site of AdSS) and was potentiated by the presence of vitamin C. This antibacterial activity of PLP gives hope for its future use against H. pylori.
Additional file 2: of Development and psychometric validation of a scoring questionnaire to assess healthy lifestyles among adolescents in Catalonia
Creators: name: LluĂ­S Costa-Tutusaus
name: Guerra-Balic, Myriam
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: VISA-TEEN Questionnaire. (PDF 1462Â kb)
MOESM6 of A Bayesian inference method for the analysis of transcriptional regulatory networks in metagenomic data
Creators: name: Hobbs, Elizabeth
name: Talmo Pereira
name: OâNeill, Patrick
name: Erill, Ivan
Publisher: name: Figshare
Year: 2016
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 6. Distribution of distance between high-confidence sites (bp) for promoters with more than one high-confidence site.
Investigation of the inhibitory properties of azo-dyes on chorismate synthase from Paracoccidioides brasiliensis
Creators: name: Fuchs, Katharina
name: Totaro, Massimo G.
name: Toplak, Marina
name: Bijelic, Aleksandar
name: Macheroux, Peter
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: The efficient inhibition of 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) by the broad-spectrum herbicide glyphosate validates the shikimate pathway as a promising target for developing antimicrobial, fungicidal and herbicidal agents. The last enzyme of this pathway, chorismate synthase (CS), catalyses an unusual reaction, making it an attractive target for novel inhibitors. Therefore, we tested a series of azo-dyes for their inhibitory potential against CS from the pathogenic fungus Paracoccidioides brasiliensis (PbCS) and identified the azo-dye PH011669 that exhibits a dissociation (Kd) and 50% inhibitory constant (IC50) of 1.1 ± 0.1 and 10 ± 1 µM, respectively. Molecular docking and MD simulations provided insight into the mode of inhibition, showing that PH011669 binds to the enzyme’s active site primarily through electrostatic interactions. Thus, our study is the first to integrate structural and computational methods to guide future efforts towards designing the next generation of CS inhibitors.
Additional file 1: of Development and psychometric validation of a scoring questionnaire to assess healthy lifestyles among adolescents in Catalonia
Creators: name: LluĂ­S Costa-Tutusaus
name: Guerra-Balic, Myriam
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Marine Biology

description: Non-validated English version from VISA-TEEN. (PDF 264Â kb)
Comparative metabolic study of the chloroform fraction of three Cystoseira species based on UPLC/ESI/MS analysis and biological activities
Creators: name: Aly, Shaza H.
name: Elissawy, Ahmed M.
name: Hassab, Mahmoud A. El
name: Majrashi, Taghreed A.
name: Hassan, Fatma E.
name: Elkaeed, Eslam B.
name: Eldehna, Wagdy M.
name: Singab, Abdel Nasser B.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: This study aims to investigate the phytoconstituents of the chloroform fraction of three Cystoseira spp. namely C. myrica, C. trinodis, and C. tamariscifolia using UPLC/ESI/MS technique. The results revealed the identification of 19, 20 and 11 metabolites in C. myrica, C. trinodis, and C. tamariscifolia, respectively mainly terpenoids, flavonoids, phenolic acids and fatty acids. Also, an in vitro antioxidant study using FRAP and DPPH assays was conducted where the chloroform fraction of C. trinodis displayed the highest antioxidant activity in both assays, which would be attributed to its highest total phenolics and total flavonoids. Besides, the investigation of COX-1, α-glucosidase and α-amylase inhibitory activities were performed. Regarding C. trinodis, it showed the strongest inhibitory activity towards COX-1. Moreover, it showed potent inhibitory activity towards α-glucosidase and α-amylase enzymes. According to the molecular docking studies, the major compounds characterised showed efficient binding to the active sites of the target enzymes.
Novel isobavachalcone derivatives induce apoptosis and necroptosis in human non-small cell lung cancer H1975 cells
Creators: name: Chen, Jie
name: Zhao, Long
name: Xu, Meng-Fan
name: Huang, Di
name: Sun, Xiao-Long
name: Zhang, Yu-Xin
name: Li, Hong-Mei
name: Wu, Cheng-Zhu
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biochemistry
Medicine
Cell Biology
Molecular Biology
Pharmacology
Chemical Sciences not elsewhere classified
Cancer
Hematology

description: In this study, seventeen isobavachalcone (IBC) derivatives (1–17) were synthesised, and evaluated for their cytotoxic activity against three human lung cancer cell lines. Among these derivatives, compound 16 displayed the most potent cytotoxic activity against H1975 and A549 cells, with IC50 values of 4.35 and 14.21 μM, respectively. Compared with IBC, compound 16 exhibited up to 4.11-fold enhancement of cytotoxic activity on human non-small cell lung cancer H1975 cells. In addition, we found that compound 16 suppressed H1975 cells via inducing apoptosis and necroptosis. The initial mechanism of compound 16 induced cell death in H1975 cells involves the increasing of Bax/Bcl-2 ratio and Cyt C protein level, down-regulating of Akt protein level, and cleaving caspase-9 and -3 induced apoptosis; the up-regulation of RIP3, p-RIP3, MLKL, and p-MLKL levels induced necroptosis. Moreover, compound 16 also caused mitochondrial dysfunction, thereby decreasing cellular ATP levels, and resulting in excessive reactive oxygen species (ROS) accumulation.
Allocrangonyx Schellenberg 1937
Creators: name: Nakano, Takafumi
name: Tomikawa, Ko
name: Grygier, Mark J.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Amphipoda
Allocrangonyctidae
Allocrangonyx

description: Genus Allocrangonyx Schellenberg, 1937a
Allocrangonyx Schellenberg, 1937a: 33.— Barnard & Barnard, 1983: 447 –448.
Allocrangonyx Schellenberg, 1936 (sic).— Hubricht, 1943: 687.— Holsinger, 1971: 318 –319.— Holsinger, 1986: 542.— Holsinger, 1989: 948 –949.— Lowry & Myers, 2013: 44.
Allocrangonyx Schellenberg, 1938 (sic).— Bousfield, 1977: 304.
Type species: Niphargus pellucidus Mackin, 1935, fixed by monotypy.
description: Published as part of Nakano, Takafumi, Tomikawa, Ko & Grygier, Mark J., 2018, Rediscovered syntypes of Procrangonyx japonicus, with nomenclatural consideration of some crangonyctoidean subterranean amphipods (Crustacea: Amphipoda: Allocrangonyctidae, Niphargidae, Pseudocrangonyctidae) in Zootaxa 4532 (1), DOI: 10.11646/zootaxa.4532.1.4, http://zenodo.org/record/2615065
Additional file 1: Figure S1. of Overexpression of the long non-coding RNA PVT1 is correlated with leukemic cell proliferation in acute promyelocytic leukemia
Creators: name: Chengwu Zeng
name: Xibao Yu
name: Lai, Jing
name: Lijiang Yang
name: Shaohua Chen
name: Yangqiu Li
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: PVT1 expression in NB4-R2 cells treated with ATRA. NB4-R2 cells were cultured in RPMI 1640 supplemented with 10 % FBS in the presence and absence of 1 μM ATRA for the indicated time points. Total RNA was extracted, and PVT1 levels were determined by qPCR. (DOCX 51 kb)
Design, synthesis, and bioevaluation of 1h-pyrrolo[3,2-c]pyridine derivatives as colchicine-binding site inhibitors with potent anticancer activities
Creators: name: Wang, Chao
name: Zhang, Yujing
name: Yang, Shanbo
name: Shi, Lingyu
name: Rong, Rong
name: Zhang, Tingting
name: Wu, Yudong
name: Xing, Dongming
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biophysics
Biochemistry
Cell Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Hematology

description: A new series of 1H-pyrrolo[3,2-c]pyridine derivatives were designed and synthesised as colchicine-binding site inhibitors. Preliminary biological evaluations showed that most of the target compounds displayed moderate to excellent antitumor activities against three cancer cell lines (HeLa, SGC-7901, and MCF-7) in vitro. Among them, 10t exhibited the most potent activities against three cancer cell lines with IC50 values ranging from 0.12 to 0.21 μM. Tubulin polymerisation experiments indicated that 10t potently inhibited tubulin polymerisation at concentrations of 3 μM and 5 μM, and immunostaining assays revealed that 10t remarkably disrupted tubulin microtubule dynamics at a concentration of 0.12 μM. Furthermore, cell cycle studies and cell apoptosis analyses demonstrated that 10t at concentrations of 0.12 μM, 0.24 μM, and 0.36 μM significantly caused G2/M phase cell cycle arrest and apoptosis. The results of molecular modelling studies suggested that 10t interacts with tubulin by forming hydrogen bonds with colchicine sites Thrα179 and Asnβ349. In addition, the prediction of physicochemical properties disclosed that 10t conformed well to the Lipinski’s rule of five.
Diagnostic yield and cost analysis of electrocardiographic screening in Swiss paediatric athletes
Creators: name: Albiński, Maciej K.
name: Saubade, Mathieu
name: Menafoglio, Andrea
name: Meyer, Philippe
name: Capelli, Bruno
name: Perrin, Tilman
name: Trachsel, Lukas Daniel
name: Hagemeyer, Daniel
name: Casagrande, Damien
name: Wilhelm, Matthias
name: Bénaïm, Charles
name: Pirrello, Tony
name: Albrecht, Silvia
name: Schmied, Christian Marc
name: Mivelaz, Yvan
name: Tércier, Stéphane
name: Baggish, Aaron L.
name: Gabus, Vincent
Publisher: name: Elsevier
Year: 2022
Subjects: Athletes Child Electrocardiography Screening Sudden cardiac death

description: Objectives: Athletes performing sports on high level are at increased risk for sudden cardiac death. This includes paediatric athletes, even though data on screening strategies in this age group remain scarce. This study aimed to assess electrocardiogram interpretation criteria in paediatric athletes and to evaluate the cost of screening. Methods: National, multicentre, retrospective, observational study on 891 athletes of paediatric age (<18 years) evaluated by history, physical examination and 12-lead electrocardiogram. The primary outcome measure was abnormal electrocardiogram findings according to the International Recommendations for Electrographic Interpretation in Athletes. The secondary outcome measure was cost of screening. Results: 19 athletes (2.1%) presented abnormal electrocardiogram findings requiring further investigations, mainly abnormal T-wave inversion. These 19 athletes were predominantly males, performing endurance sports with a mean volume of 10 weekly hours for a mean duration of 6 years of training. Further investigations did not identify any relevant pathology. All athletes were cleared for competition with regular follow-up. Total costs of the screening were 108,860 USD (122 USD per athlete). Conclusions: Our study using the International Recommendations for Electrographic Interpretation in Athletes identified a low count of abnormal findings in paediatric athletes, yet raising substantially the cost of screening. Hence, the utility of electrocardiogram-inclusive screening of paediatric athletes remains to be elucidated by longitudinal data.
Procrangonyx japonicus
Creators: name: Nakano, Takafumi
name: Tomikawa, Ko
name: Grygier, Mark J.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Amphipoda
Pseudocrangonyctidae
Procrangonyx
Procrangonyx japonicus

description: Procrangonyx japonicus (Uéno, 1930)
(Figs 1, 2)
Eucrangonyx japonicus Uéno, 1930: 21 –23, fig. 1.
Eocrangonyx japonicus.— Tomikawa & Shinoda, 2016: 585 –593, figs. 2–6.
Material examined. Syntypes. KUZ Z1759, two individuals, collected from underground water in Tokyo, Japan, on 26 January 1930 (Uéno 1930; Fig. 1); these two specimens, upon which the original description of the species was based, are automatically fixed as syntypes under Article 73.2 of the Code.
Redescription of uropod 3. Left uropod 3 of one individual still discernable. Inner ramus absent; outer ramus uniarticulate, with two long, robust setae and seven short, simple, slender setae (Fig. 2).
Remarks. It was hard to observe the detailed morphological characteristics of the syntypes due to their poor condition. The preservative solution of the specimens appears to have dried up, whereupon the amphipods became flattened against the bottom of the glass tube and were damaged (Figs 1A, 2A). However, the left uropod 3 of one of them was sufficiently well preserved to confirm that its outer ramus comprises only a single article. Therefore, Uéno’s (1930) original description of uropod 3 was correct. This means that P. japonicus is variable in this respect, the outer ramus being either uniarticulate (present syntype) or biarticulate (Tomikawa & Shinoda 2016). Molecular phylogenetic analysis has shown that Procrangonyx primoryensis Stock & Jo, 1990 is a member of a monophyletic lineage consisting otherwise only of Pseudocrangonyx species (Tomikawa et al. 2016). It is clear that Procrangonyx and Pseudocrangonyx are phylogenetically close, and Procrangonyx, despite its being nomenclaturally available as demonstrated above, could potentially be reduced to an invalid junior synonym of Pseudocrangonyx, as previous studies have implied (Sidorov & Holsinger 2007; Tomikawa & Shinoda 2016). In this context, a molecular phylogenetic study of the relations of Procrangonyx japonicus is a necessary future step.
description: Published as part of Nakano, Takafumi, Tomikawa, Ko & Grygier, Mark J., 2018, Rediscovered syntypes of Procrangonyx japonicus, with nomenclatural consideration of some crangonyctoidean subterranean amphipods (Crustacea: Amphipoda: Allocrangonyctidae, Niphargidae, Pseudocrangonyctidae) in Zootaxa 4532 (1), DOI: 10.11646/zootaxa.4532.1.4, http://zenodo.org/record/2615065
Additional file 3: Table S2. of Allelic imbalance of multiple sclerosis susceptibility genes IKZF3 and IQGAP1 in human peripheral blood
Creators: name: Keshari, Pankaj
name: Harbo, Hanne
name: Kjell-Morten Myhr
name: Aarseth, Jan
name: Bos, Steffan
name: Berge, Tone
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: Hematology
subject: Plant Biology
subject: Computational Biology

description: Details of excluded measurements per investigated gene. (PDF 82 kb)
Developing Nonlinear Microwave Impedance Microscopy
Creators: name: Zhu, Julia
Publisher: name: Stanford Digital Repository
Year: 2024
Subjects: MIM
Microwave Impedance Microscopy
Nonlinear Materials

description: Microwave impedance microscopy (MIM) is a mature scanning probe technique that has been widely used to characterize materials with macroscopic-level quantum effects. Currently, most MIM measurements are made using the same excitation and detection frequencies. In this thesis, we present the design and development of nonlinear MIM, which allows us to measure the nonlinear electrical susceptibility and conductivity of materials. Nonlinear MIM distinguishes itself from other forms of nonlinear measurement techniques for its simplicity and applicability to a wider range of material systems. Using finite element analysis, we further provide a physical interpretation of the nonlinear MIM signal. Moreover, nonlinear scans on a high-resistivity silicon anti-dot patterned heavy surface implantation were performed to show a proof-of-concept of our room-temperature implementation. This advancement paves the way for further studying quantum and topological systems, including imaging semiconductor carrier distributions, topological insulators, and ferroelectric polarization domains.
Design and synthesis of doublecortin-like kinase 1 inhibitors and their bioactivity evaluation
Creators: name: Pan, Pengming
name: Ji, Dengbo
name: Li, Zhongjun
name: Meng, Xiangbao
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Virology

description: Doublecortin-like kinase 1 (DCLK) is a microtubule-associated serine/threonine kinase that is upregulated in a wide range of cancers and is believed to be related to tumour growth and development. Upregulated DCLK1 has been used to identify patients at high risk of cancer progression and tumours with chemotherapy-resistance. Moreover, DCLK1 has been identified as a cancer stem cell (CSC) biomarker in various cancers, which has received considerable attention recently. Herein, a series of DCLK1 inhibitors were prepared based on the previously reported XMD8-92 structure. Among all the synthesised compounds, D1, D2, D6, D7, D8, D12, D14, and D15 showed higher DCLK1 inhibitory activities (IC50 40–74 nM) than XMD8-92 (IC50 161 nM). Compounds D1 and D2 were selective DCLK1 inhibitors as they showed a rather weak inhibitory effect on LRRK2. The antiproliferative activities of these compounds were also preliminarily evaluated. The structure-activity relationship revealed by our compounds provides useful guidance for the further development of DCLK1 inhibitors.
Additional file 1: Table S2. of Accuracy of imputation using the most common sires as reference population in layer chickens
Creators: name: Heidaritabar, Marzieh
name: Calus, Mario
name: Vereijken, Addie
name: Groenen, Martien
name: Bastiaansen, John
Publisher: name: Figshare
Year: 2015
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology

description: Proportion of diversity for 62 sires and maternal grand sires (MGS) of G0.
Revisions: Digital Interactive
Creators: name: Hölling, Hanna Barbara
name: Schilling, Lara
name: Adang, Lisa
name: Ahn, Cabelle
name: Hill, Linden
name: Gardner, Andrew
Publisher: name: Brad Graduate Center
Year: 2015
Subjects: media
conservation
film
revisions
changeability
boredom
nothingness
authorship
event
Fluxus
materiality
silence
time
trace

description: This digital interactive is integral to the exhibition Revisions—Zen for Film, at the Bard Graduate Center Focus Gallery, New York, September 17, 2015–January 10, 2016, which was developed during a two-year research, teaching, and curatorial project within the curricular initiative Cultures of Conservation supported by Andrew W. Mellon Foundation. Curator of the exhibition: Hanna B. Hölling, Andrew W. Mellon Visiting Professor, Cultures of Conservation Director of the Gallery and Executive Editor, Gallery Publications: Nina Stritzler-Levine Head of Focus Gallery Project: Ivan Gaskell Chief Curator and Associate Director of the Gallery: Marianne Lamonaca Focus Gallery Project Coordinator and Associate Curator: Ann Marguerite Tartsinis Acting Associate Curator: Caroline Hannah Exhibition designer: Ian Sullivan Director of the Digital Media Lab: Kimon Keramidas Dean for Academic Administration and Student Affairs: Elena Pinto Simon Digital Interactive Design Linked by Air: Daniel Michelson and Laurel Schwulst Student participants: Lara Schilling (curatorial fellow [LS]), Lisa Adang [LA], Cabelle Ahn [CA], Andrew Gardner [AG], Linden Hill [LH]. The interactive has been virtualized and can now be viewed (not interacted with) online.
Niphargus speziae Schellenberg 1937
Creators: name: Nakano, Takafumi
name: Tomikawa, Ko
name: Grygier, Mark J.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Amphipoda
Niphargidae
Niphargus
Niphargus speziae

description: Niphargus speziae Schellenberg, 1937b
Niphargus foreli speziae Schellenberg, 1937b: 8 –10, fig. 4.— Barnard & Barnard, 1983: 691.
Niphargus speziae Schellenberg, 1936 (sic).— Karaman & Ruffo, 1986: 531.— Stoch, 1998: 230.
Syntypes: two males, deposited in the Naturkundemuseum Leipzig and in Berlin’s Museum für Naturkunde, respectively; type status fixed under Article 73.2 of the Code.
description: Published as part of Nakano, Takafumi, Tomikawa, Ko & Grygier, Mark J., 2018, Rediscovered syntypes of Procrangonyx japonicus, with nomenclatural consideration of some crangonyctoidean subterranean amphipods (Crustacea: Amphipoda: Allocrangonyctidae, Niphargidae, Pseudocrangonyctidae) in Zootaxa 4532 (1), DOI: 10.11646/zootaxa.4532.1.4, http://zenodo.org/record/2615065
Ein gutes Stallklima für die Pferde – was heisst das genau?
Un bon climat d’écurie pour les chevaux, qu’est-ce exactement?
Creators: name: Herholz, Cornelia
Publisher: name: Schweizerischer Verband für Pferdesport SVPS
Year: 2021

description: Der Begriff Stallklima kennzeichnet die Umweltbedingungen von Tieren und Menschen in Ställen. Dabei ist das Zusammenspiel von Lufttemperatur, Luftfeuchtigkeit, Luftgeschwindigkeit,Temperatur der Boden- und Wandoberflächen sowie der Wärmeleitfähigkeit der Liegefläche massgeblich für die Qualität des Stallklimas. Das Stallklima wird beeinflusst durch die Zusammensetzung der Luft aus Gasen, Stäuben, Bioaerosolen (in der Luft schwebende Mikroorganismen) und weiteren chemischen und biologischen Faktoren. An der Hochschule für Agrar-, Forst- und Lebensmittelwissenschaften (HAFL) wurden verschiedene, aktuelle Untersuchungen dazu durchgeführt, die am Brennpunkt Pferd 2021 vorgestellt werden.
description: Le terme «climat d’écurie» désigne les conditions environnementales auxquelles sont exposés les umains et les animaux dans une écurie. Les facteurs qui déterminent la qualité du climat d’écurie sont les interactions entre la température,l’humidité et la vitesse de l’air, la température du sol et de la surface des parois ainsi que la conductivité thermique de la litière utilisée dans les aires de repos. Le climat d’écurie dépend de la composition de l’air, constitué de gaz, de poussières, de bioaérosols (des micro-organismes suspendus dans l’air) ainsi que d’autres facteurs chimiques et biologiques. Diverses études à ce sujet ont été menées à la Haute école des sciences agronomiques, forestières et alimentaires (HAFL) et seront présentées dans le cadre de «Brennpunkt Pferd 2021», une rencontre de spécialistes dédiée au sujet de la détention des chevaux.
Additional file 4: Figure S1. of Small RNA sequencing and degradome analysis of developing fibers of short fiber mutants Ligon-lintles-1 (Li

                1
              ) and −2 (Li

                2
              ) revealed a role for miRNAs and their targets in cotton fiber elongation
Creators: name: Naoumkina, Marina
name: Thyssen, Gregory
name: Fang, David
name: Hinchliffe, Doug
name: Florane, Christopher
name: Jenkins, Johnie
Publisher: name: Figshare
Year: 2016
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: RT-qPCR expression analysis of highly expressed miRNAs in developing cotton fibers. The relative expression level is shown on the left y-axis of each graph. Asterisks indicate significant (p-value
Additional file 3: of High-specificity bioinformatics framework for epigenomic profiling of discordant twins reveals specific and shared markers for ACPA and ACPA-positive rheumatoid arthritis
Creators: name: Gomez-Cabrero, David
name: Almgren, Malin
name: Sjöholm, Louise
name: Hensvold, Aase
name: Ringh, Mikael
name: Tryggvadottir, Rakel
name: Kere, Juha
name: Scheynius, Annika
name: Acevedo, Nathalie
name: Reinius, Lovisa
name: Taub, Margaret
name: Montano, Carolina
name: Aryee, Martin
name: Feinberg, Jason
name: Feinberg, Andrew
name: Tegnér, Jesper
name: Klareskog, Lars
name: Catrina, Anca
name: Ekström, Tomas
Publisher: name: Figshare
Year: 2016
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Computational Biology

description: Supplementary methods. The file includes extended description of aspects of the bioinformatic analysis. (DOCX 25 kb)
Additional file 5: of Strengthening hepatitis B and C surveillance in Europe: results from the two global hepatitis policy surveys (2013 and 2014)
Creators: name: Lazarus, Jeffrey
name: Mozalevskis, Antons
name: Safreed-Harmon, Kelly
name: Eramova, Irina
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: Reporting by Member States on other sources of strategic information and capacities for disease burden estimation. (DOCX 39 kb)
Soziale Arbeit ist...
Creators: name: Ballinari, Silvio
Publisher: name: Berner Fachhochschule BFH, Soziale Arbeit
Year: 2021

description: Die Kolumne bietet eine Carte blanche für Fachfremde und öffnet den Blick für das, was sie mit Sozialer Arbeit verbinden oder was an ihrer Arbeit sozial ist.
Additional file 1: of Strengthening hepatitis B and C surveillance in Europe: results from the two global hepatitis policy surveys (2013 and 2014)
Creators: name: Lazarus, Jeffrey
name: Mozalevskis, Antons
name: Safreed-Harmon, Kelly
name: Eramova, Irina
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology

description: Annex E: Responding to viral hepatitis: the World Health Organization/World Hepatitis Alliance 2012 survey of national governments. (PDF 85 kb)
Additional file 3: of Decision aids to help older people make health decisions: a systematic review and meta-analysis
Creators: name: Weert, Julia Van
name: Munster, Barbara Van
name: Sanders, Remco
name: RenĂŠ Spijker
name: Hooft, Lotty
name: Jansen, Jesse
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Results Meta-Analysis. (DOCX 161Â kb)
Additional file 3: of Strengthening hepatitis B and C surveillance in Europe: results from the two global hepatitis policy surveys (2013 and 2014)
Creators: name: Lazarus, Jeffrey
name: Mozalevskis, Antons
name: Safreed-Harmon, Kelly
name: Eramova, Irina
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Reporting by Member States on the existence of a written national viral hepatitis strategy or plan. (DOCX 30 kb)
MOESM1 of Obesity inhibits the osteogenic differentiation of human adipose-derived stem cells
Creators: name: Strong, Amy
name: Hunter, Ryan
name: Jones, Robert
name: Bowles, Annie
name: Dutreil, Maria
name: Gaupp, Dina
name: Hayes, Daniel
name: Gimble, Jeffrey
name: Levi, Benjamin
name: McNulty, Margaret
name: Bunnell, Bruce
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Additional file 1: Figure S1. Estradiol restores the osteogenic differentiation capacity of obASCs. (A) lnASCs (n=6 donors) and obASCs (n=6 donors) were cultured in CDS-ODM supplemented with estradiol. After 14 days, cells were stained with Alizarin Red. Scale bar represents 200 μm. (B) To quantify the amount of Alizarin Red staining, stains were eluted with CPC and optical density was read. Bars, ± SEM. *, P
Messung der Nachhaltigkeit auf Betriebsebene: welches Instrument für welchen Zweck?
Creators: name: Roesch, A.
name: Marton, S.
name: Thalmann, Christian
name: Schader, C.
name: Grenz, Jan
name: Gaillard, G.
Publisher: name: Agroscope Liebefeld-Posieux ALP
Year: 2018
Subjects: sustainability
method
farm level

description: Für die Bewertung der Nachhaltigkeit auf der Ebene des Landwirtschaftsbetriebes liegen drei in der Schweiz entwickelte Methoden vor: RISE, SMART und SALCAsustain. Im vorliegenden Artikel werden die drei Methoden anhand eines Kriterienkatalogs und einiger konkreter Beispiele miteinander verglichen, mit dem Ziel, dem Leser, der Leserin die Entscheidung zu erleichtern, welches Tool für die eigene spezifische Anwendung und Zielgruppe am besten geeignet ist. Alle drei Methoden decken die Nachhaltigkeit umfassend ab, und aus den Ergebnissen lassen sich für die entsprechenden Interessengruppen konkrete Verbesserungsmassnahmen und Entscheidungen ableiten. Die Ausführungen zeigen, dass sich SALCAsustain für die Beantwortung von Forschungsfragen sowie die Analyse unterschiedlicher betrieblicher Managementstrategien eignet. Die Stärke von RISE ist seine flexible Anwendbarkeit, die es ermöglicht, RISE in der Beratung, im Unterricht und zum Vergleich von Betrieben und Betriebsgruppen einzusetzen. SMART erlaubt ein rasches Screening der betrieblichen Nachhaltigkeit und liefert dabei Ergebnisse, die sich auch zwischen Betrieben vergleichen und einfach an Dritte kommunizieren lassen. Die Wahl der geeigneten Methode hängt daher von der Fragestellung und der Zielgruppe ab.
Additional file 2: of Decision aids to help older people make health decisions: a systematic review and meta-analysis
Creators: name: Weert, Julia Van
name: Munster, Barbara Van
name: Sanders, Remco
name: RenĂŠ Spijker
name: Hooft, Lotty
name: Jansen, Jesse
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: Characteristics of included studies. (DOCX 41Â kb)
Roboter, App und Mensch renovieren gemeinsam historische Fenster
Creators: name: Von Gunten, Simon
Publisher: name: Berner Fachhochschule BFH, Architektur, Holz und Bau/Technik und Informatik
Year: 2023

description: Die Basler Firma Quadra Ligna ist an das BFH-Forschungsinstitut für digitale Bau- und Holzwirtschaft IdBH herangetreten, um gemeinsam den Renovationsprozess historischer Fenster zu digitalisieren. Das Resultat: eine App, ein Robotersystem und stolze Mitarbeitende.
Selection signatures in Shetland ponies
Creators: name: Frischknecht, M.
name: Flury, Christine
name: Leeb, T.
name: Rieder, S.
name: Neuditschko, M.
Publisher: name: Wiley
Year: 2016
Subjects: Composite Selection Score
Horse

description: Shetland ponies were selected for numerous traits including small stature, strength, hardiness and longevity. Despite the different selection criteria, Shetland ponies are well known for their small stature. We performed a selection signature analysis including genome‐wide SNPs of 75 Shetland ponies and 76 large‐sized horses. Based upon this dataset, we identified a selection signature on equine chromosome (ECA) 1 between 103.8 Mb and 108.5 Mb. A total of 33 annotated genes are located within this interval including the IGF1R gene at 104.2 Mb and the ADAMTS17 gene at 105.4 Mb. These two genes are well known to have a major impact on body height in numerous species including humans. Homozygosity mapping in the Shetland ponies identified a region with increased homozygosity between 107.4 Mb and 108.5 Mb. None of the annotated genes in this region have so far been associated with height. Thus, we cannot exclude the possibility that the identified selection signature on ECA1 is associated with some trait other than height, for which Shetland ponies were selected.
MOESM3 of Obesity inhibits the osteogenic differentiation of human adipose-derived stem cells
Creators: name: Strong, Amy
name: Hunter, Ryan
name: Jones, Robert
name: Bowles, Annie
name: Dutreil, Maria
name: Gaupp, Dina
name: Hayes, Daniel
name: Gimble, Jeffrey
name: Levi, Benjamin
name: McNulty, Margaret
name: Bunnell, Bruce
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Additional file 3: Figure S3. No observable differences in lnASCs and obASCs during early bone regeneration. Critical size calvarial defects were created in the parietal bone of nude mice and assessed after 2 weeks. (A) Representative images of microCT scanning. (B) Quantification of microCT. Scale bar represents 1 mm. Bars, Âą SEM.
Energy Storage System Hybridization Algorithm for Mobility Applications Based on Future Battery and Fuel Cell Technologies
Creators: name: Lemoine, Bruno Eric Marc
name: Caliandro, Priscilla
name: Wannemacher, Thomas
name: Baumann, Nils
name: Jost, Monika
Publisher: name: IEEE
Year: 2023
Subjects: Hybridization
energy storage system
battery
fuel cell
mobility
aviation
optimization
sizing
forecasts

description: Shifting the mobility paradigm from fossil fuel to electric propulsion system poses several challenges to a large extent attributed to the low energy density of storage systems. However, technology improvements and an accurate combination of new propulsion systems can facilitate the electrification of the mobility sector. For the first time, a hybridization algorithm is developed to evaluate the optimal configuration of future Energy Storage System (ESS) to facilitate the design of systems such as aircrafts or ships. The algorithm is based on operational behaviors and high-level performances to determine the optimal solution through a standard random search of the input variables. To feed the algorithm, forecasts including estimated performances are carried out on new energy storage technologies such as Fuel Cells (FCs), batteries, and hydrogen storage. The hybridization algorithm is then applied to the design of a 50 passengers’ regional electric aircraft in 2040. The results suggest that the best ESS includes a Solid-State Battery (SSB) of 457 kWh, a 1788 kW Solid-Oxide Fuel Cell (SOFC) plant and consumes 190.9 kg of hydrogen. This configuration appears to be the optimal trade-off to minimize weight, volume, and costs.
title: "Pietà", Bazzi Giovanni Antonio detto Sodoma, inv. 462 (ITA/EN)
title: Scheda catalogo digitale Borghese
titleType: AlternativeTitle
Creators: name: De Melis, Gabriele
name: Galleria Borghese
Publisher: name: Galleria Borghese
Year: 2024

description: Pubblicazione delle schede delle opere conservate nel museo ed estratte dal catalogo digitale di Galleria Borghese, nelle due versioni esistenti online, in italiano e inglese.

Collegamento al catalogo digitale:

ITA: https://www.collezionegalleriaborghese.it/

EN: https://www.collezionegalleriaborghese.it/en
Synthesis biological evaluation and molecular docking of isatin hybrids as anti-cancer and anti-microbial agents
Creators: name: Altamimi, Mohammad
name: Syed, Saeed Ali
name: Tuzun, Burak
name: Alhazani, Mohammad Rashid
name: Alnemer, Osamah
name: Bari, Ahmed
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Isatin, known as 1H-indole-2,3-dione, was originally recognised as a synthetic molecule until its discovery in the fruits of the cannonball tree, Couroupita guianensis. It is naturally occurring in plants of the genus Isatis and serves as a metabolic derivative of adrenaline in humans. Isatin possesses significant pharmacological importance, and its synthetic versatility has prompted extensive interest in its derivative compounds due to their diverse biological and pharmacological properties. These derivatives represent a valuable class of heterocyclic compounds with potential applications as precursors for synthesizing numerous valuable drugs. In the pursuit of advancing our research on isatin hybrids, we investigate the utilisation of readily available hydrazonoindolin-2-one and isatin as starting materials for the synthesis of a wide range of analogues. Characterisation of the synthesized compounds was carried out through various analytical techniques. Furthermore, the obtained compounds were subjected to extensive testing to evaluate their anticancer and antimicrobial activities. Specifically, their efficacy against key proteins, namely Staphylococcus aureus protein (PDB ID: 1JIJ), Escherichia coli protein (PDB ID: 1T9U), Pseudomonas aeruginosa protein (PDB ID: 2UV0), and Acinetobacter baumannii protein (PDB ID: 4HKG), was examined through molecular docking calculations. Several molecules, such as 3, 4, 6, 16, and 19, displayed remarkable activity against the renal cancer cell line UO-31. Additionally, the results of antimicrobial activity testing revealed that compound 16 exhibited significant cytotoxicity against Candida albicans and Cryptococcus neoformans. Subsequently, ADME/T calculations were performed to gain insights into the potential effects and reactions of these molecules within human metabolism. This comprehensive study provides valuable insights into the potential pharmacological applications of isatin derivatives and underscores their significance in drug development.