cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Lipid larceny: channelizing host lipids for establishing successful pathogenesis by bacteria
Creators: name: Chatterjee, Ritika
name: Chowdhury, Atish Roy
name: Mukherjee, Debapriya
name: Chakravortty, Dipshikha
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Lipids are complex organic compounds made up of carbon, oxygen, and hydrogen. These play a diverse and intricate role in cellular processes like membrane trafficking, protein sorting, signal transduction, and bacterial infections. Both Gram-positive bacteria (Staphylococcus sp., Listeria monocytogenes, etc.) and Gram-negative bacteria (Chlamydia sp., Salmonella sp., E. coli, etc.) can hijack the various host-lipids and utilize them structurally as well as functionally to mount a successful infection. The pathogens can deploy with various arsenals to exploit host membrane lipids and lipid-associated receptors as an attachment for toxins’ landing or facilitate their entry into the host cellular niche. Bacterial species like Mycobacterium sp. can also modulate the host lipid metabolism to fetch its carbon source from the host. The sequential conversion of host membrane lipids into arachidonic acid and prostaglandin E2 due to increased activity of cPLA-2 and COX-2 upon bacterial infection creates immunosuppressive conditions and facilitates the intracellular growth and proliferation of bacteria. However, lipids’ more debatable role is that they can also be a blessing in disguise. Certain host-lipids, especially sphingolipids, have been shown to play a crucial antibacterial role and help the host in combating the infections. This review shed light on the detailed role of host lipids in bacterial infections and the current understanding of the lipid in therapeutics. We have also discussed potential prospects and the need of the hour to help us cope in this race against deadly pathogens and their rapidly evolving stealthy virulence strategies.
Chemical characterization of the globular cluster NGC 5634 associated to the Sagittarius dwarf spheroidal galaxy
Creators: name: Carretta, Eugenio
name: Bragaglia, Angela
name: Lucatello, Sara
name: D'Orazi, Valentina
name: Gratton, Raffaele G.
name: Donati, Paolo
name: Sollima, Antonio
name: Sneden, Chris
Publisher: name: arXiv
Year: 2017
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: As part of our on-going project on the homogeneous chemical characterization of multiple stellar populations in globular clusters (GCs), we studied NGC 5634, associated to the Sagittarius dwarf spheroidal galaxy, using high-resolution spectroscopy of red giant stars collected with FLAMES@VLT. We present here the radial velocity distribution of the 45 observed stars, 43 of which are member, the detailed chemical abundance of 22 species for the seven stars observed with UVES-FLAMES, and the abundance of six elements for stars observed with GIRAFFE. On our homogeneous UVES metallicity scale we derived a low metallicity [Fe/H]=-1.867 +/-0.019 +/-0.065 dex (+/-statistical +/-systematic error) with sigma=0.050 dex (7 stars). We found the normal anti-correlations between light elements (Na and O, Mg and Al), signature of multiple populations typical of massive and old GCs. We confirm the associations of NGC 5634 to the Sgr dSph, from which the cluster was lost a few Gyr ago, on the basis of its velocity and position and the abundance ratios of alpha and neutron capture elements.
description: 16 pages, 10 figures, 11 tables; accepted for publication on Astronomy and Astrophysics
Evaluating the bioequivalence of metronidazole tablets and analyzing the effect of in vitro dissolution on in vivo absorption based on PBPK modeling
Creators: name: Zhang, Shuqi
name: Fang, Mengna
name: Zhang, Qi
name: Li, Xiaoting
name: Zhang, Tianhong
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Metronidazole, a BCS class I drug, could be waived based on the BCS principles, thus enabling in vitro dissolution data as a surrogate of BE study. However, the impact of dissolution profiles of metronidazole tablets on the in vivo performance has never been studied systematically. So the aim of the present study was to conduct a multipronged approach of in vitro dissolution, in silico simulation, and in vivo study to evaluate the effect of dissolution performance on oral absorption of metronidazole tablets, as well as the accuracy of PBPK model to predict the oral bioavailability for BCS I drug. The results demonstrated that the PBPK models were successfully established for metronidazole immediate-release tablets. Bioequivalence comparison in dogs indicated that the test products were bioequivalent to the Reference (80%–125%, 90% CI), and even their dissolution profiles in vitro were significantly different. And the prediction of oral pharmacokinetics of the three formulations in human was also highly similar. In addition, the behavior of in vitro dissolution profiles and in vivo absorption was elucidated. These findings will contribute to understanding the potential risks during the formulation development and justifying the biowaiver for metronidazole tablets.
Acinetobacter baumannii up-regulates LncRNA-GAS5 and promotes the degradation of STX17 by blocking the activation of YY1
Creators: name: An, Zhiyuan
name: Ding, Wenyi
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Acinetobacter baumanniitriggers autophagy, affects the degradation of autophagy, and causes severe inflammatory injury. LncRNA growth arrest-specific transcript 5 (LncRNA-GAS5) and Yin and Yang 1 (YY1) are known to play an important role in the regulation of autophagy, however, the precise role of LncRNA-GAS5 and YY1 in the damage to autophagy caused by Acinetobacter baumanniiremains unclear. The aim of this study was to investigate the role of LncRNA-GAS5 and YY1 in the regulation of autophagy induced by Acinetobacter baumannii. We found that LncRNA-GAS5 was up-regulated following infection with Acinetobacter baumannii, thus resulting in the degradation of STX17, autophagy disorders, and the aggravated replication of Acinetobacter baumannii. We also analyzed the mechanism of interaction between LncRNA-GAS5 and YY1 and found that YY1 regulated its expression in a negative manner by binding to the promoter of LncRNA-GAS5. LncRNA-GAS5 and YY1 had opposite effects on the expression of STX17, this process maintained the stable expression of STX17. Following Acinetobacter baumannii infection, YY1 was down regulated and then separated from the binding region of LncRNA-GAS5, thus resulting in the activation of LncRNA-GAS5 transcription and reduction in STX17 protein expression. Finally, we infected LncRNA-GAS5 knockdown mice with Acinetobacter baumannii, the expression levels of IFN-β in the lungs increased significantly, this alleviated lung injury. In conclusion, our work demonstrated the mechanism by which Acinetobacter baumannii infection can cause the degradation of STX17. We also demonstrated that LncRNA-GAS5 may be a potential therapeutic target for the treatment of lung injury induced by Acinetobacter baumannii.
Foreknowledge, fate and freedom
Creators: name: Rennick, Stephanie
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: "Foreknowledge, fate and freedom" is concerned with diagnosing and debunking a pervasive and prevalent folk intuition: that a foreknown future would be problematically, and freedom-hinderingly, fixed. In it, I discuss foreknowledge in and of itself, but also as a lens through which we can examine other intuitions and concepts ; the apparent asymmetry of future and past; worries about fate and free will; notions of coincidence and likelihood; assumptions about God, time travel and ourselves.This thesis provides the first philosophical map of a region of conceptualised space visited often by the folk and popular culture, and as a result ties together a host of disparate threads in the literature. I make three central claims: 1. The folk intuition is wrong in rejecting foreknowledge wholesale on the basis that it entails a problematically fixed future, and thereby undermines our freedom. 2. Foreknowledge gives rise to new problems, and sheds new light on old ones, but none of these are insurmountable. 3. The same paradoxes thought to plague backwards time travel can arise in foreknowledge cases, and can be defused in the same way. I conclude that foreknowledge is puzzling, but possible: it neither inevitably entails fatalism nor precludes free will. While its consequences may be strange, they are not sufficient to vindicate the folk intuition.
Additional file 3: of Overexpression of RNF38 facilitates TGF-Î˛ signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma
Creators: name: Peng, Rui
name: Zhang, Peng-Fei
name: Yang, Xuan
name: Wei, Chuan-Yuan
name: Huang, Xiao-Yong
name: Cai, Jia-Bin
name: Lu, Jia-Cheng
name: Gao, Chao
name: Sun, Hai-Xiang
name: Gao, Qiang
name: Bai, Dou-Sheng
name: Shi, Guo-Ming
name: Ke, Ai-Wu
name: Fan, Jia
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Figure S1. Analysis RNF38 mRNA level in gastrointestinal tumor vs. normal tissues. A-D. RNF38 mRNA level was up-regulated in colon cancer, gastric cancer, and liver cancer, compared to normal tissues (All data retrieved from www.oncomine.org ). (PDF 114 kb)
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Cart. 188 (11 H 73), f. 0260v
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Archives départementales de la Côte-d'Or, Cart. 188 (11 H 73), f. 0260v, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Archives départementales de la Côte-d'Or, Cart. 188 (11 H 73), f. 0260v, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
MOESM1 of Impact of I/D polymorphism of angiotensin-converting enzyme (ACE) gene on myocardial infarction susceptibility among young Moroccan patients
Creators: name: Wiam Hmimech
name: Idrissi, Hind
name: Brehima Diakite
name: Korchi, Farah
name: Baghdadi, Dalila
name: Idrissi, Hind Tahri Joutey Hassani
name: Meriem Haboub
name: Habbal, Rachida
name: Sellama Nadifi
Publisher: name: figshare
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Computational Biology

description: Additional file 1: Table S1. Hardy–Weinberg equilibrium (HWE) among cases and control. Table 2. Traditional risk factors vs I/D ACE genotypes distribution among
Searches for the Anomalous FCNC Top-Higgs Couplings with Polarized Electron Beam at the LHeC
Creators: name: Wang, XiaoJuan
name: Sun, Hao
name: Luo, Xuan
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In this paper, we study the single top and Higgs associated production $\rm e^- p\rightarrow ν_e \bar{t} \rightarrow ν_e h \bar{q}(h\rightarrow b\bar{b})$ in the top-Higgs FCNC couplings at the LHeC with the electron beam energy of $E_{e}$ = 60 GeV and $E_{e}$ = 120 GeV, combination of a 7 TeV and 50 TeV proton beam. With the possibility of e-beam polarization ($p_{e}$ = 0, $\pm0.6$), we distinct the Cut-based method and the Multivariate Analysis (MVA) based method, and compare with the current experimental and theoretical limits. It is shown that the branching ratio Br $\rm(t\to uh)$ can be probed to 0.113 (0.093) $\%$, 0.071 (0.057) $\%$, 0.030 (0.022) $\%$ and 0.024 (0.019) $\%$ with the Cut-based (MVA-based) analysis at ($E_{p}$, $E_{e}$) = (7 TeV, 60 GeV), ($E_{p}$, $E_{e}$) = (7 TeV, 120 GeV), ($E_{p}$, $E_{e}$) = (50 TeV, 60 GeV) and ($E_{p}$, $E_{e}$) = (50 TeV, 120 GeV) beam energy and 1$σ$ level. With the possibility of e-beam polarization, the expected limits can be probed down to 0.090 (0.073) $\%$, 0.056 (0.045) $\%$, 0.024 (0.018) $\%$ and 0.019 (0.015) $\%$, respectively.
description: 13pages, 5 figures. Advance in High Energy Physics
Archaeological correlates of the united monarchy of ancient Israel: evaluating and reconsidering interpretive frameworks
Creators: name: Thomas, Zachary
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: This thesis seeks to apply the idea of ancient Israel as a patriarchal and patrimonial state within its ancient Near Eastern context as adumbrated by David Schloen to the debate concerning the historicity of the biblical United Monarchy. Specifically, this thesis will apply this sociological idea to the archaeological aspects of this debate, a debate that has so far not taken account of the form and nature of ancient Israelite society as an aspect of the interpretation of the relevant archaeology and associated issues. Rather it has been content with a functionalist approach to archaeological interpretation that has not yet explored or justified its own assumptions about the social world and the legitimation of authority in ancient Israel. This thesis will discuss and analyse this functionalist approach, before moving on to apply a sociologically-informed approach centred upon patrimonial society to the methodology of the interpretation of the archaeological correlates for the United Monarchy.
Additional file 1: of Hierarchizing caries risk factors among first-year university students in Nice (France): a cross-sectional study
Creators: name: Ceinos, Romain
name: Marie-France Bertrand
name: Cucchi, Céline
name: Lupi, Laurence
Publisher: name: figshare
Year: 2017
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: questionnaire used for the interview of the students. The questionnaire consisted in five parts including socio-economic information, daily diet-related behaviors, addictive behaviors, oral hygiene habits and oral health–related behaviors. (DOCX 17 kb)
Stacking-dependent electronic property of trilayer graphene epitaxially grown on Ru(0001)
Creators: name: Que, Yande
name: Xiao, Wende
name: Chen, Hui
name: Wang, Dongfei
name: Du, Shixuan
name: Gao, Hong-Jun
Publisher: name: arXiv
Year: 2017
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The growth, atomic structure, and electronic property of trilayer graphene (TLG) on Ru(0001) were studied by low temperature scanning tunneling microscopy and spectroscopy in combined with tight-binding approximation (TBA) calculations. TLG on Ru(0001) shows a flat surface with a hexagonal lattice due to the screening effect of the bottom two layers and the AB-stacking in the top two layers. The coexistence of AA- and AB-stacking in the bottom two layers leads to three different stacking orders of TLG, namely, ABA-, ABC-, and ABB-stacking. STS measurements combined with TBA calculations reveal that the density of states of TLG with ABC- and ABB-stacking is characterized by one and two sharp peaks near to the Fermi level, respectively, in contrast to the V-shaped feature of TLG with ABA-stacking. Our work demonstrates that TLG on Ru(0001) might be an ideal platform for exploring stacking-dependent electronic properties of graphene.
description: 18 pages, 4 figures
Hepatitis B virus middle surface antigen loss promotes clinical variant persistence in mouse models
Creators: name: Lin, Junyu
name: Li, Jing
name: Xie, Peilin
name: Han, Yue
name: Yu, Demin
name: Chen, Jia
name: Zhang, Xinxin
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Hepatitis B virus (HBV) middle surface antigen (MHBs) mutation or deletion occurs in patients with chronic HBV infection. However, the functional role of MHBs in HBV infection is still an enigma. Here, we reported that 7.33% (11/150) isolates of CHB patients had MHBs start codon mutations compared with 0.00% (0/146) in acute hepatitis B (AHB) patients. Interestingly, MHBs loss accounted for 11.88% (126/1061) isolates from NCBI GenBank, compared with 0.09% (1/1061) and 0.00% (0/1061) for HBV large surface antigen (LHBs) loss and HBV small surface antigen (SHBs) loss, respectively. One persistent HBV clone of genotype B (B56, MHBs loss) from a CHB patient was hydrodynamically injected into BALB/c mice. B56 persisted for >70 weeks in BALB/c mice, whereas B56 with restored MHBs (B56M+) was quickly cleared within 28 days. Serum cytokine assays demonstrated that CXCL1, CXCL2, IL-6 and IL-33 were significantly increased during rapid HBV clearance in B56M+ mice. Furthermore, the enhancers and promoters of B56 were proved to be required for B56 persistence in mice. Ablating MHBs expression improved the persistence of a new clone (HBV1.3, genotype B) which was recreated by using enhancers and promoters of B56. These data demonstrated that MHBs deletion can promote the persistence of specific HBV variants in a hydrodynamic mouse model. MHBs re-expression restored a rapid clearance of HBV, which was accompanied by cytokine responses including the elevation of CXCL1, CXCL2, IL-6 and IL-33.
Multiwavelength picture of the blazar S5 0716+714 during its brightest outburst
Creators: name: Manganaro, Marina
name: Pedaletti, Giovanna
name: Doert, Marlene
name: Bastieri, Denis
name: Ramazani, Vandad Fallah
name: Gasparrini, Dario
name: Lindfors, Elina
name: Lott, Benoit
name: Nievas, Mireia
name: Rani, Bindu
name: Thompson, David J.
name: Angelakis, Emmanouil
name: Borman, George
name: Gurwell, Mark
name: Hovatta, Talvikki
name: Itoh, Ryosuke
name: Jorstad, Svetlana
name: Kraus, Alex
name: Krichbaum, Thomas P.
name: Kuin, Paul
name: Lähteenmäki, Anne
name: Larionov, Valeri
name: Lien, Amy Yarleen
name: Myserlis, Ioannis
name: Tornikoski, Merja
name: Troitsky, Ivan
name: Zensus, J. Anton
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: S5 0716+714 is a well known BL Lac object, one of the brightest and most active blazars. The discovery in the Very High Energy band (VHE, E > 100 GeV) by MAGIC happened in 2008. In January 2015 the source went through the brightest optical state ever observed, triggering MAGIC follow-up and a VHE detection with 13σ significance (ATel 6999). Rich multiwavelength coverage of the flare allowed us to construct the broad-band spectral energy distribution of S5 0716+714 during its brightest outburst. In this work we will present the preliminary analysis of MAGIC and Fermi-LAT data of the flaring activity in January and February 2015 for the HE (0.1 < HE < 300 GeV) and VHE band, together with radio (Metsähovi, OVRO, VLBA, Effelsberg), sub-millimeter (SMA), optical (Tuorla, Perkins, Steward, AZT-8+ST7, LX-200, Kanata), X-ray and UV (Swift-XRT and UVOT), in the same time-window and discuss the time variability of the multiwavelength light curves during this impressive outburst.
description: 7 pages, 3 figures, proceeding of the JETS 2016 conference
Additional file 4: of Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma
Creators: name: Peng, Rui
name: Zhang, Peng-Fei
name: Yang, Xuan
name: Wei, Chuan-Yuan
name: Huang, Xiao-Yong
name: Cai, Jia-Bin
name: Lu, Jia-Cheng
name: Gao, Chao
name: Sun, Hai-Xiang
name: Gao, Qiang
name: Bai, Dou-Sheng
name: Shi, Guo-Ming
name: Ke, Ai-Wu
name: Fan, Jia
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Figure S2. Confocal microscopy images of RNF38 and AHNAK. Shown are HCCLM3-NC cells (blue, DAPI; green, RNF38; red, AHNAK). Scale: 2000 × . (PDF 113 kb)
THE EFFECT OF INSTRUCTIONAL TECHNOLOGY ON MATHEMATICAL WORD PROBLEM SOLVING FOR STUDENTS WITH DISABILITIES: A META-ANALYSIS
Creators: name: Kim, Soojung
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: classificationCode: 390411
subject: Special education and disability

description: This meta-analysis aimed to investigate the effectiveness of instructional technology on mathematical word problem solving for elementary and middle school students with disabilities. This study examined specifically digital technology such as computers and tablets. From the article identification based on inclusion and exclusion criteria, a total of 21 studies were included in this study. The 21 included studies consisted of seven group design studies and 14 single-case design studies. This study computed an overall effect and analyzed moderators of group design studies (Hedges’ g) and single-case design studies (between-case standardized mean difference) in the same analyses. The overall effect of instructional technology on word problem solving across 21 studies was large (Hedges’ g = 1.18, 95% CI = 0.84, 1.52). The study characteristics, including publication years, intervention settings, intervention agents, technology devices, technology types, and mathematics topics, were found to moderate the effects of interventions. The four studies, which assessed the generalization of word problem solving skills learned from the instructional technology to the standardized assessments, showed a near moderate effect (Hedges’ g = 0.49, 95% CI = 0.09, 0.9). Limitations of this study and directions for research are discussed.
Implications of an updated ultraviolet background for the ionization mechanisms of intervening Ne VIII absorbers
Creators: name: Hussain, Tanvir
name: Khaire, Vikram
name: Srianand, Raghunathan
name: Muzahid, Sowgat
name: Pathak, Amit
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Ne VIII absorbers seen in QSO spectra are useful tracers of warm ionized gas, when collisional ionization is the dominant ionization process. While photoionization by the ultraviolet background (UVB) is a viable option, it tends to predict large line-of-sight thickness for the absorbing gas. Here, we study the implications of the recently updated UVB at low-z to understand the ionization mechanisms of intervening Ne VIII absorbers. With the updated UVB, one typically needs higher density and metallicity to reproduce the observed ionic column densities under photoionization. Both reduce the inferred line-of-sight thicknesses of the absorbers. We find a critical density of $\geq5\times10^{-5}$ cm$^{-3}$ above which the observed N(Ne VIII)/N(O VI) can be reproduced by pure collisional processes. If the gas is of near solar metallicity (as measured for the low ions) then the cooling timescales will be small (
description: 11 pages, 5 figures, 2 tables. Accepted for publication in MNRAS
Carrier driven coupling in ferromagnetic oxide heterostructures
Creators: name: Chang, Ching-Hao
name: Das, Sujit
name: Kumar, Sanjeev
name: Ganesh, R.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Transition metal oxides are well known for their complex magnetic and electrical properties. When brought together in heterostructure geometries, they show particular promise for spintronics and colossal magnetoresistance applications. In this letter, we propose a new mechanism for the coupling between layers of itinerant ferromagnetic materials in heterostructures. The coupling is mediated by charge carriers that strive to maximally delocalize through the heterostructure to gain kinetic energy. In doing so, they force a ferromagnetic or antiferromagnetic coupling between the constituent layers. To illustrate this, we focus on heterostructures composed of SrRuO$_3$ and La$_{1-x}$A$_{x}$MnO$_3$ (A=Ca/Sr). Our mechanism is consistent with antiferromagnetic alignment that is known to occur in multilayers of SrRuO$_3$-La$_{1-x}$A$_{x}$MnO$_3$. To support our assertion, we present a minimal Kondo-lattice model which reproduces the known magnetization properties of such multilayers. In addition, we discuss a quantum well model for heterostructures and argue that the spin-dependent density of states determines the nature of the coupling. As a smoking gun signature, we propose that bilayers with the same constituents will oscillate between ferromagnetic and antiferromagnetic coupling upon tuning the relative thicknesses of the layers.
description: 5 pages, 6 figures
Diffuse optical tomography for 3D imaging in breast cancer and lymphoedema
Creators: name: Chen, Ao
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Diffuse optimal tomography (DOT) is an emerging non-invasive and inexpensive medical imaging modality which utilises near infrared light in certain spectral ranges to examine the tissues, and reconstructs the distribution of intensity of optical parameters of internal organs through the measurement of optical intensity distribution on the tissue surface. In order to produce high quality imaging, we need to build a mathematical model which can accurately describe the photon transmission in biological tissue. In present research, diffusion equation is commonly used as the forward model in DOT, where the diffusion equation is a diffusion approximation of the radiative transfer equation that states the transmission of photons in the tissue. In order to solve the mathematics efficiently and to finalise the quality DOT images, this report studies the mathematical models and the image reconstruction algorithms. In this project, we have constructed a laboratory DOT prototype which has a 633 nm laser and a photondiode circuit. Moreover, this project presents mathematical expressions of forward problems, which is a photon transmission model in diffusion equation that is based on radiative equation, and solves the inverse problem which is DOT image reconstruction via Gauss-Newton and Levenberg-Marquardt models. The reconstruction results of an Electrical impedance tomography and diffuse optical tomography reconstruction software EIDORS) simulation under a 2 dimensional model with different optical coefficients and the validity of the image reconstruction algorithm are presented.
Ferromagnetic and insulating behavior of LaCoO3 films grown on a (001) SrTiO3 substrate. A simple ionic picture explained ab initio
Creators: name: Fumega, Adolfo O
name: Pardo, Victor
Publisher: name: arXiv
Year: 2017
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: This paper shows that the oxygen vacancies observed experimentally in thin films of LaCoO3 subject to tensile strain are thermodynamically stable according to ab initio calculations. By using DFT calculations, we show that oxygen vacancies on the order of 6 % forming chains perpendicular to the (001) direction are more stable than the stoichiometric solution. These lead to magnetic Co2+ ions surrounding the vacancies that couple ferromagnetically. The remaining Co3+ cations in an octahedral environment are non magnetic. The gap leading to a ferromagnetic insulating phase occurs naturally and we provide a simple ionic picture to explain the resulting electronic structure.
description: 7 pages, 7 figures
PROVING THE SOLUTION OF DIFFERENTIAL EQUATIONS WITH LINEAR OPERATOR COEFFICIENTS THROUGH THEOREMS
Creators: name: Muhammademinov Alijon  Azizjon o'g'li Student of Andijan State University. Hakimov Baxtiyarjon  Muzaffar o'g'li Student of Andijan State University
Publisher: name: Zenodo
Year: 2024

description: As we know, the science of partial differentials is an integral part of our life. They can be divided into two types. These are called correct and incorrect questions. In this topic, we will mainly work on the equation of heat distribution and talk about its incorrectly set problems.

Key words: heat diffusion equation, differential equation, operator, function, complex differentiation
title: Διαδικασία εξυγίανσης και ειδικής διαχείρισης των επιχειρήσεων στην ελληνική νομοθεσία
title: The corporate restructuring and special management process under the Greek legislation
Creators: name: Δερμιτζακη Ελενη Ιωαννα
Publisher: name: Technical University of Crete
Year: 2023

description: Θέμα της παρούσας εργασίας αποτελεί η εξέταση των νόμων 4738/2020 και 4307/2014 αναφορικά με την προπτωχευτική διαδικασία εξυγίανσης και τη διαδικασία ειδικής διαχείρισης των επιχειρήσεων αντίστοιχα. Θα γίνει μία ενδελεχής παρουσίαση των σταδίων τους και παράθεση σημαντικών δικαστικών αποφάσεων, ενώ θα πραγματοποιηθεί και συγκριτική επισκόπηση των δύο διαδικασιών.
Shifting US-China Policy Postures: options for Australia
Creators: name: Cleverly, Richard James
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: International relations are passing through a crucial phase, specifically since the end of the Cold War in which the post-Second World War institutions and alliances are being increasingly challenged by the rising powers, particularly China. The rules-based order, mainly championed by the United States through its alliance system is being challenged externally by the countries like China and internally by the new administration of Donald John Trump.In a sense, a situation is arising in which China is challenging the existing world order by forwarding its sovereignty claims over the South China Sea and impinging on freedom of navigation, exerting pressure against the US alliance system as well as leveraging its relation with trade and investment. This thesis identifies and examines Trump's postures that could most affect Australia and the Asia-Pacific, focusing on the South China Sea Dispute, the US-led alliance system, and trade. It then examines China's resultant postures and the possible implications to Australia, before concluding with a look at Australia's responses and the possible options Canberra might employ in its relationship with China moving forward. Through a descriptive analysis within an offensive realist framework, this study concludes that Australia ultimately needs to take a much firmer stance towards China in areas it has traditionally remained more ambivalent. Particularly with the convening/supporting of increased security dialogues between Australia and other regional states, while simultaneously displaying understanding of China's cultural sensitivities, by supporting and advocating for a less confrontational approach in other areas, especially concerning Freedom of Navigation Operations (FONOPs).
Lognormal Distribution of Cosmic Voids in Simulations and Mocks
Creators: name: Russell, Esra
name: Pycke, Jean-Renaud
Publisher: name: arXiv
Year: 2016
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Statistics Theory (math.ST)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: Following up on previous studies, we here complete a full analysis of the void size distributions of the Cosmic Void Catalog (CVC) based on three different simulation and mock catalogs; dark matter, haloes and galaxies. Based on this analysis, we attempt to answer two questions: Is a 3-parameter log-normal distribution a good candidate to satisfy the void size distributions obtained from different types of environments? Is there a direct relation between the shape parameters of the void size distribution and the environmental effects? In an attempt to answer these questions, we here find that all void size distributions of these data samples satisfy the 3-parameter log-normal distribution whether the environment is dominated by dark matter, haloes or galaxies. In addition, the shape parameters of the 3-parameter log-normal void size distribution seem highly affected by environment, particularly existing substructures. Therefore, we show two quantitative relations given by linear equations between the skewness and the maximum tree depth, and variance of the void size distribution and the maximum tree depth directly from the simulated data. In addition to this, we find that the percentage of the voids with nonzero central density in the data sets has a critical importance. If the number of voids with nonzero central densities reaches greater and or equal to 3.84 percentage in a simulation/mock sample, then a second population is observed in the void size distributions. This second population emerges as a second peak in the log-normal void size distribution at larger radius.
description: 11 pages, 6 figures, accepted to ApJ main journal
High Child-Pugh and CRUB65 scores predict mortality of decompensated cirrhosis patients with COVID-19: A 23-center, retrospective study
Creators: name: Xiao, Yong
name: Wu, Dongwen
name: Shi, Xiao
name: Liu, Shuzhong
name: Hu, Xudong
name: Zhou, Chenliang
name: Tian, Xia
name: Liu, Huimin
name: Long, Hui
name: Li, Zhihong
name: Wang, Ji
name: Tan, Tao
name: Xu, Ying
name: Chen, Bitao
name: Liu, Ting
name: Zhang, Heng
name: Zheng, Shihua
name: Hu, Shunlin
name: Song, Jun
name: Tang, Jie
name: Song, Jichun
name: Cheng, Zhengwei
name: Xu, Weitian
name: Shen, Yongxiang
name: Yu, Wenhu
name: Xu, Yong
name: Li, Jiao
name: Zhou, Jing
name: Wang, Fen
name: Chen, Mingkai
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Background: COVID-19 has rapidly become a major health emergency worldwide. The characteristic, outcome, and risk factor of COVID-19 in patients with decompensated cirrhosis remain unclear. Methods: Medical records were collected from 23 Chinese hospitals. Patients with decompensated cirrhosis and age- and sex-matched non-liver disease patients were enrolled with 1:4 ratio using stratified sampling. Results: There were more comorbidities with higher Chalson Complication Index (p < 0.001), higher proportion of patients having gastrointestinal bleeding, jaundice, ascites, and diarrhea among those patients (p < 0.05) and in decompensated cirrhosis patients. Mortality (p < 0.05) and the proportion of severe ill (p < 0.001) were significantly high among those patients. Patients in severe ill subgroup had higher mortality (p < 0.001), MELD, and CRUB65 score but lower lymphocytes count. Besides, this subgroup had larger proportion of patients with abnormal (PT), activated partial thromboplatin time (APTT), D-Dimer, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBL) and Creatinine (Cr) (p < 0.05). Multivariate logistic regression for severity shown that MELD and CRUB65 score reached significance. Higher Child-Pugh and CRUB65 scores were found among non-survival cases and multivariate logistic regression further inferred risk factors for adverse outcome. Receiver Operating Characteristic (ROC) curves also provided remarkable demonstrations for the predictive ability of Child-Pugh and CRUB65 scores. Conclusions: COVID-19 patients with cirrhosis had larger proportion of more severely disease and higher mortality. MELD and CRUB65 score at hospital admission may predict COVID-19 severity while Child-Pugh and CRUB65 score were highly associated with non-survival among those patients.
Additional file 1: of Multivariable regression analysis of list experiment data on abortion: results from a large, randomly-selected population based study in Liberia
Creators: name: Moseson, Heidi
name: Gerdts, Caitlin
name: Dehlendorf, Christine
name: Hiatt, Robert
name: Vittinghoff, Eric
Publisher: name: figshare
Year: 2017
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Annotated R Code. (DOCX 166Â kb)
Phenol-soluble modulins α are major virulence factors of Staphylococcus aureus secretome promoting inflammatory response in human epidermis
Creators: name: Damour, Alexia
name: Robin, Brandon
name: Deroche, Luc
name: Broutin, Lauranne
name: Bellin, Nicolas
name: Verdon, Julien
name: Lina, Gérard
name: Leclère, Franck Marie
name: Garcia, Magali
name: Cremniter, Julie
name: Lévêque, Nicolas
name: Bodet, Charles
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Staphylococcus aureus is a skin commensal microorganism commonly colonizing healthy humans. Nevertheless, S. aureus can also be responsible for cutaneous infections and contribute to flare-up of inflammatory skin diseases such as atopic dermatitis (AD), which is characterized by dysbiosis of the skin microbiota with S. aureus as the predominant species. However, the role of major virulence factors of this pathogen such as phenol-soluble modulin (PSM) toxins in epidermal inflammation remains poorly understood. Stimulation of primary human keratinocytes with sublytic concentrations of synthetic and purified PSM α3 resulted in upregulation of a large panel of pro-inflammatory chemokine and cytokine gene expression, including CXCL1, CXCL2, CXCL3, CXCL5, CXCL8, CCL20, IL-1α, IL-1β, IL-6, IL-36γ and TNF-α, while inducing the release of CXCL8, CCL20, TNF-α and IL-6. In addition, using S. aureus culture supernatant from mutants deleted from genes encoding either α-type PSMs or all PSM production, PSMs were shown to be the main factors of S. aureus secretome responsible for pro-inflammatory mediator induction in human keratinocytes. On the other hand, α-type PSM-containing supernatant triggered an intense induction of pro-inflammatory mediator expression and secretion during both topical and basal layer stimulation of an ex vivo model of human skin explants, a physiologically relevant model of pluristratified epidermis. Taken together, the results of this study show that PSMs and more specifically α-type PSMs are major virulence factors of S. aureus inducing a potent inflammatory response during infection of the human epidermis and could thereby contribute to AD flare-up through exacerbation of skin inflammation.
Linewidth enhancement factor measurement based on FM-modulated optical injection: application to rare-earth doped active medium
Creators: name: Thorette, Aurélien
name: Romanelli, Marco
name: Vallet, Marc
Publisher: name: arXiv
Year: 2017
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: A new method for measuring the linewidth enhancement factor of a laser is proposed. It is based on frequency-modulated optical injection, combined with dual-frequency laser operation. The linewidth enhancement factor α is deduced from the experimental data using a theoretical analysis based on a standard rate equation model. As the intracavity power is kept constant, the method allows to free the process from the thermal effects that are usually present in AM/FM techniques. Measurement of α=0.28$\pm$0.04 in a diode-pumped Nd:YAG laser demonstrates that the method is well-suited for characterizing small values of α.
title: 02_0300
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Streptococcus agalactiae glyceraldehyde-3-phosphate dehydrogenase (GAPDH) elicits multiple cytokines from human cells and has a minor effect on bacterial persistence in the murine female reproductive tract
Creators: name: Sullivan, Matthew J.
name: Goh, Kelvin G. K.
name: Thapa, Ruby
name: Chattopadhyay, Debasish
name: Ipe, Deepak S.
name: Duell, Benjamin L.
name: Katupitiya, Lahiru
name: Gosling, Dean
name: Acharya, Dhruba
name: Ulett, Glen C.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Streptococcus agalactiae glyceraldehyde 3-phosphate dehydrogenase (GAPDH), encoded by gapC, is a glycolytic enzyme that is associated with virulence and immune-mediated protection. However, the role of GAPDH in cellular cytokine responses to S. agalactiae, bacterial phagocytosis and colonization of the female reproductive tract, a central host niche, is unknown. We expressed and studied purified recombinant GAPDH (rGAPDH) of S. agalactiae in cytokine elicitation assays with human monocyte-derived macrophage, epithelial cell, and polymorphonuclear leukocyte (PMN) co-culture infection models. We also generated a S. agalactiae mutant that over-expresses GAPDH (oeGAPDH) from gapC using a constitutively active promoter, and analyzed the mutant in murine macrophage antibiotic protection assays and in virulence assays in vivo, using a colonization model that is based on experimental infection of the reproductive tract in female mice. Human cell co-cultures produced interleukin (IL)-1β, IL-6, macrophage inflammatory protein (MIP)-1, tumor necrosis factor (TNF)-α and IL-10 within 24 h of exposure to rGAPDH. PMNs were required for several of these cytokine responses. However, over-expression of GAPDH in S. agalactiae did not significantly affect measures of phagocytic uptake compared to an empty vector control. In contrast, oeGAPDH-S. agalactiae showed a small but statistically significant attenuation for persistence in the reproductive tract of female mice during the chronic phase of infection (10–28 days post-inoculation), relative to the vector control. We conclude that S. agalactiae GAPDH elicits production of multiple cytokines from human cells, and over-expression of GAPDH renders the bacterium more susceptible to host clearance in the female reproductive tract. One-sentence summary: This study shows Streptococcus agalactiae glyceraldehyde 3-phosphate dehydrogenase, an enzyme that functions in glycolysis, gluconeogenesis and virulence, modifies phagocytosis outcomes, including cytokine synthesis, and affects bacterial persistence in the female reproductive tract.