Chemical Testing to Prevent Cancer: Research Translation
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The CBCRP Chemicals Safety Testing research program is an innovative effort to generate better tools for identifying chemicals in our environment that may increase breast cancer risk. Our translation project will 1) help the researchers from the Chemicals Safety Testing projects frame their questions to better meet the needs of decision-makers and advocacy communities, and 2) interpret their findings for regulatory and public policy settings where better information is needed to improve decision-making about chemical use.
 
 
 
 
 
 
 
 Research question(s) or central hypotheses:
 
 We wish to explore how the chemical safety testing grantees can collaborate and refine their questions to be most relevant, how their research can best inform decision-making in chemical testing, and how to support translation of the findings to a community of advocates and the public.
 
 
 
 
 
 
 
 General methodology:
 
 We will form an advisory group composed of Chemical Safety Testing researchers, representatives from government research and regulatory programs, breast cancer and public health advocates, and scientists from academia, government, and the private sector. This group will meet to improve research collaboration and to help translate the research for regulatory decision-makers, advocates, and the public. We have obtained commitments to participate from leading scientists at Environmental Protection Agency, the National Institute for Environmental Health Sciences, and the National Toxicology Program, and also from four leading breast cancer advocacy organizations. In addition to the group meetings, we will develop and maintain a project website to serve as a portal to information on chemicals testing and breast cancer, and we will work with advocate partners to help them develop educational materials and/or meetings for advocacy communities and the public. Finally, we will write and publish a peer-reviewed paper to summarize emerging research under the CBCRP chemicals testing research initiative, its practical applications, and remaining knowledge gaps.
 
 
 
 
 
 
 
 Innovative elements:
 
 It is uncommon to conduct a companion project that works in parallel with basic research to increase its relevance and applicability. We anticipate that this project will amplify the impact of the basic research being conducted under the chemical testing grants, increasing their impact on decision-making in chemicals testing and improving the knowledge and understanding of both advocacy communities and the public 
 
 
 
 
 
 
 
 Advocacy involvement and relevance to the human issues associated with breast cancer:
 
 By working closely with advocate partners throughout the project, we aim to maximize the relevance of the Chemicals Safety Testing research for breast cancer prevention. Advocates will participate directly in meetings of the advisory/working group, provide an opportunity for advocate leaders to convey their priorities, ask questions, and observe progress. We will also collaborate with advocate partners on dissemination and provide technical support to any who are interested in organizing a public conference related to the chemicals testing and breast cancer initiative or in developing educational materials relevant to the program.
 
 
 
 
 
 
 
 Publications: 
 
 
 
 BCScreen: A gene panel to test for breast carcinogenesis in chemical safety screening