cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Transcription factor expression as a predictor of colon cancer prognosis: A machine learning practice
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2020
Subjects: Colon cancer
Transcription factor
Machine learning
Cancer prognosis

description: © 2020 The Author(s). Background: Colon cancer is one of the leading causes of cancer deaths in the USA and around the world. Molecular level characters, such as gene expression levels and mutations, may provide profound information for precision treatment apart from pathological indicators. Transcription factors function as critical regulators in all aspects of cell life, but transcription factors-based biomarkers for colon cancer prognosis were still rare and necessary. Methods: We implemented an innovative process to select the transcription factors variables and evaluate the prognostic prediction power by combining the Cox PH model with the random forest algorithm. We picked five top-ranked transcription factors and built a prediction model by using Cox PH regression. Using Kaplan-Meier analysis, we validated our predictive model on four independent publicly available datasets (GSE39582, GSE17536, GSE37892, and GSE17537) from the GEO database, consisting of 925 colon cancer patients. Results: A five-transcription-factors based predictive model for colon cancer prognosis has been developed by using TCGA colon cancer patient data. Five transcription factors identified for the predictive model is HOXC9, ZNF556, HEYL, HOXC4 and HOXC6. The prediction power of the model is validated with four GEO datasets consisting of 1584 patient samples. Kaplan-Meier curve and log-rank tests were conducted on both training and validation datasets, the difference of overall survival time between predicted low and high-risk groups can be clearly observed. Gene set enrichment analysis was performed to further investigate the difference between low and high-risk groups in the gene pathway level. The biological meaning was interpreted. Overall, our results prove our prediction model has a strong prediction power on colon cancer prognosis. Conclusions: Transcription factors can be used to construct colon cancer prognostic signatures with strong prediction power. The variable selection process used in this study has the potential to be implemented in the prognostic signature discovery of other cancer types. Our five TF-based predictive model would help with understanding the hidden relationship between colon cancer patient survival and transcription factor activities. It will also provide more insights into the precision treatment of colon cancer patients from a genomic information perspective.
Rental housing and urban property: The archaeological and social analysis of insulae in Roman Ostia from the 1st to the mid-4th century CE.
Creators: name: Tipton, Katherine
Publisher: name: Graduate Studies
Year: 2017
Subjects: subject: Archaeology
subject: roman housing
subject: toilets
subject: rental housing
subject: urban property
subject: roman law
subject: roman society
subject: roman archaeology

description: Rental housing was abundant in the Roman city. Evidence for this form of housing is found in almost every structural type: horrea, terme, balnea, insulae, etc. It stands to reason that the evidence for the relationship between the owners or operators of the buildings and the tenants would be visible in the archaeological record. The insulae of Ostia Antica confirm this suggestion through the amenity of upper floor toilets. Repairs to these features and their late addition to structures substantiate how important they were to the buildings’ function. Furthermore, they establish that there was a binding contractual relationship between those who owned/operated the buildings and their tenants. The legal texts, mainly found in the Digest of Justinian, provide very little corroborating evidence regarding these features. However, they do clarify that the contracts were reciprocal, under obligatio, and unique to each tenant, most likely because the agreement was verbal. The jurists were often circuitous when considering the rental housing contract, most likely embracing the fact that the dominus dictated the terms. Within the ambiguity of the contracts, the physical evidence of the upper floor toilets and their maintenance is situated, demonstrating not all rentals were a run-down derelict mess and that the tenants had some ability to enforce their right to use and enjoy their home. The reaction from those who owned and operated the buildings was to place the upper floor toilets in a stairway or corridor, a space outside of the living quarters, but still accessible for tenants and maintenance. There were many purposes for owning and participating in the urban housing market. Many times this property would have been mortgaged to raise funds for further investments or to secure a political position and even as housing for clientele, which suggests that these buildings were kept in good working order for more reasons than for the tenant’s use, but for property value and assessment. The image of rental housing and urban property in Ostia Antica is one of integration among a diverse collection of structures, which demonstrates coordination, progress and a genuine interest from those who participated in it.
Static Analysis of Run-Time Errors in Embedded Real-Time Parallel C Programs
Creators: name: Miné, Antoine
Publisher: name: arXiv
Year: 2012
Subjects: subject: Programming Languages (cs.PL)
subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences
subject: D.2.4; F.3.1; F.3.2

description: We present a static analysis by Abstract Interpretation to check for run-time errors in parallel and multi-threaded C programs. Following our work on Astrée, we focus on embedded critical programs without recursion nor dynamic memory allocation, but extend the analysis to a static set of threads communicating implicitly through a shared memory and explicitly using a finite set of mutual exclusion locks, and scheduled according to a real-time scheduling policy and fixed priorities. Our method is thread-modular. It is based on a slightly modified non-parallel analysis that, when analyzing a thread, applies and enriches an abstract set of thread interferences. An iterator then re-analyzes each thread in turn until interferences stabilize. We prove the soundness of our method with respect to the sequential consistency semantics, but also with respect to a reasonable weakly consistent memory semantics. We also show how to take into account mutual exclusion and thread priorities through a partitioning over an abstraction of the scheduler state. We present preliminary experimental results analyzing an industrial program with our prototype, Thésée, and demonstrate the scalability of our approach.
Regulation of Aquaporin 3 Expression in Intestinal Epithelial Cells by Tumour Necrosis Factor Alpha and Interferon Gamma
Creators: name: Peplowski, Michael Augustyn
Publisher: name: Graduate Studies
Year: 2015
Subjects: Biology--Cell
Biology--Molecular
Pharmacology

description: Electrolyte and water balance are tightly regulated by the host in the gastrointestinal tract. Inflammatory bowel diseases, namely Crohn’s disease and ulcerative colitis, are associated with decreased absorption and impaired secretion, leading to impaired barrier function characterized by the development of diarrhea. Aquaporin (AQP) 3 is highly expressed in epithelial cells of the gastrointestinal tract and may be involved in the transcellular transport of water across the intestinal epithelium. We hypothesized that AQP3 expression and localization in intestinal epithelial cells are altered in intestinal inflammation and that these changes are driven by the inflammatory cytokines tumour necrosis factor (TNF) α and interferon (IFN) γ. Our studies revealed that AQP3 protein is expressed in the basolateral membrane of both human and mouse colonic epithelial cells. In mice, AQP3 was downregulated in distal colonic epithelial cells early in colitis. These changes could be reproduced in HT-29 adenocarcinoma cells treated with two cytokines involved in intestinal inflammation. Specifically, TNFα downregulated AQP3 mRNA transcription through both MEK/ERK and NF-κB signalling, acting on the transcription factor specificity protein (Sp) 3 found bound to the AQP3 promoter. In contrast, IFNγ downregulated AQP3 mRNA transcription independent of JAK2 signalling, but required signal transducer and activator of transcription (STAT) 1, whereas STAT3 appeared to be involved in the constitutive repression of AQP3 expression. Mechanisms regulating AQP3 transcription are similar to those regulating numerous ion channels involved in absorption and secretion, suggesting a common mechanism by which both ion and water transport are altered in inflammation.
Are sedentary behavior and physical activity independently associated with cardiometabolic benefits? The Hispanic Community Health Study/Study of Latinos
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2020
Subjects: Cohort study
Moderate-to-vigorous physical activity
Sedentary behavior
Cardiometabolic biomarkers
Hispanics
Latinos

description: © 2020 The Author(s). Background: Whether physical activity can reduce cardiometabolic risk particularly in understudied populations such as US Hispanics/Latinos is of public health interest. We prospectively examined the association of physical activity and cardiometabolic biomarkers in n = 8049 participants of the Hispanic Community Health Study/Study of Latinos, a community-based cohort study of 16,415 adults aged 18-74 yr who self-identified as Hispanic/Latino from four US urban centers. Methods: We assessed physical activity using accelerometry in 2008-2011 at visit 1. We assessed cardiometabolic biomarkers twice: once at visit 1 and collected a second measure in 2014-2017 at visit 2. We used survey linear regression models with changes in cardiometabolic markers as the dependent variables and quartiles of sedentary behavior or whether adults met guidelines for moderate-to-vigorous physical activity as the independent variables. Results: In normoglycemic adults without cardiovascular disease, but not in adults with evidence of cardiometabolic disease, those who were in the lowest quartile for sedentary behavior (< 10.08 h/day) had a significant decline in mean LDL-cholesterol of - 3.94 mg/dL (95% CI: - 6.37, - 1.52) compared to adults in the highest quartile (≥13.0 h/day) who exhibited a significant increase in LDL-cholesterol of 0.14 mg/dL (95% CI, - 2.15,2.42) over the six year period (P < 0.02 in fully adjusted models.) There was also a trend toward lower mean increase in HbA1c comparing the lowest with the highest quartile of sedentary behavior. Overall regardless of glycemic level or evidence of cardiometabolic disease, adults who met guidelines for moderate-to-vigorous physical activity at visit 1, had significantly lower mean increases in level of fasting glucose compared to adults not meeting guidelines in fully adjusted models. Conclusions: In this cohort of Hispanics/Latinos, being free of cardiometabolic disease and having low levels of sedentary behavior were associated with health benefits. Among all adults regardless of cardiometabolic disease, meeting guidelines for moderate-to-vigorous physical activity was associated with health benefits. Overall these data suggest that an active lifestyle may blunt the association of advancing age with worsening cardiometabolic risk factors.
¿Qué tipo de acompañamiento familiar abre una esperanza?
Creators: name: Pérez Soba, Juan José
Publisher: name: Quaderns de Polítiques Familiars: Journal of Family Policies
Year: 2023

description: “¿No ardía nuestro corazón, mientras nos hablaba por el camino?” (Lc 24,32)) Esta es la experiencia real de un verdadero acompañamiento: «arder el corazón». El Evangelio tiene la fuerza enorme de ofrecernos estas palabras que «obran el bien» y que no tienen miedo a los afectos, más bien se refiere a ellos con firmeza. Por eso, para expresar lo que significa un encuentro con Cristo que cambia una vida, emplea una palabra fundamentalmente afectiva -«arder el corazón»- que todo el mundo entiende, que remite a una experiencia y que la ilumina por dentro. Queda claro así que acompañar es conseguir que a las personas les «arda el corazón» y se puede afirmar que el prototipo de todo acompañamiento es el que Jesús hace con los discípulos de Emaús (Lc 24,13-35), donde se ve la transformación de una vida. Unas personas desanimadas, unas personas que no saben a dónde ir, vuelven convertidos en apóstoles de apóstoles. Cuando Santo Tomás se pregunta qué significa «arder el corazón», es decir, ¿qué es lo que se significa con esa palabra? ¿Qué es, para una persona, que «arda el corazón»? El Ángélico daba tres significados fundamentales. Que «arda el corazón» significa que el corazón, en parte, se consume; por otra parte, significa que calienta y, por último, que eleva. «Arder el corazón» significa estas tres cosas. Estos tres efectos son los que el acompañamiento tiene que causar en la persona que es acompañada.
description: Quaderns de Polítiques Familiars: Journal of Family Policies, Núm. 8 (2022): Núm. 8: Un cambio de mirada ante el acompañamiento familiar
Computational analysis of clinical practice guidelines : development of a software suite and document standard for storage and analysis of care maps
Creators: name: Ramraj, Varun
Publisher: name: University of British Columbia
Year: 2010

description: Clinical Practice Guidelines (CPGs) guide optimal utilization of clinical delivery of health care through evidence-based medicine, where care procedures are rigorously evaluated and improved through the examination of evidence. Care mapping is the technique of using flowcharts to graphically capture CPGs as discrete, actionable steps. Health professionals can create and use care maps to expedite and ensure excellence in optimal process workflow in patient care. Analysis of care maps would provide insight into similarities and differences in care procedures. However, quantitative analysis of care maps is difficult to perform manually, and becomes impossible as the set of care maps for comparison increases. Computational methods could be employed to obtain the required quantitative data, but current document standards for developing, sharing and visualizing care maps are not rigorous enough for computational analysis to take place. By using Bioinformatics approaches, we can solve these problems. Firstly, we can develop a standard care map file format for electronic storage. Systems Biology Markup Language (SBML), a document format used to describe biological pathways, can be used to develop the required file format. This method works because care maps are notionally very similar to biological pathways. It allows use of multiple alignment algorithms (traditionally used to align and cluster biological pathways) with these transformed care maps in order to derive quantitative data. This project involved the development of a software suite that is able to generate care maps in the SBML format and align them using an existing global multiple pathway alignment algorithm. It is part of a larger project that examines efficacy of CPGs. This would allow for two important studies to be conducted: a breadth study across multiple EDs and a longitudinal study over time within a single ED to see how it has been able to implement and adapt to the CPGs. By utilizing Bioinformatics approaches in care mapping, two important objectives were realized: the creation of a document standard for care maps, and computational comparison and contrast of CPGs. This opens up the exciting new field of Translational Informatics, which applies existing Bioinformatics concepts to e-Health, e-Medicine and Health Informatics.
Una asignatura sobre matrimonio y familia como materia docente transversal impartida en la Universidad de Piura (Perú)
Creators: name: Huarcaya, Gloria
name: Coronado, Renata
Publisher: name: Quaderns de Polítiques Familiars: Journal of Family Policies
Year: 2023

description: La asignatura Dimensión Social de la Familia analiza la situación sociodemográfica de las familias tanto peruanas como a nivel mundial ofreciendo un marco antropológico amplio de la sexualidad humana, el amor conyugal y el matrimonio. La asignatura aborda el fenómeno creciente de la cohabitación, así como el tratamiento de la familia en medios de comunicación y diferentes cuestiones sobre cultura y género. En este artículo se ofrecen los resultados de diferentes cuestionarios auto aplicados, mostrando la medición de los aprendizajes logrados por los alumnos en los distintos temas, así como su percepción sobre los beneficios personales que les ha reportado cursar la asignatura. También se muestra el interés mayoritario de los jóvenes por profundizar en temas como educación sexual, aborto, género, sexualidad y amor humano. Como conclusión cabe destacar que esta asignatura interdisciplinar resulta un medio de formación válido y eficaz para los jóvenes en su toma de decisiones futura por el impacto directo que tiene en la construcción de sus proyectos de vida.
description: Quaderns de Polítiques Familiars: Journal of Family Policies, Núm. 8 (2022): Núm. 8: Un cambio de mirada ante el acompañamiento familiar
Ensemble Dynamics and Bred Vectors
Creators: name: Balci, Nusret
name: Mazzucato, Anna L.
name: Restrepo, Juan M.
name: Sell, George R.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Atmospheric and Oceanic Physics (physics.ao-ph)
subject: Dynamical Systems (math.DS)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We introduce the new concept of an EBV to assess the sensitivity of model outputs to changes in initial conditions for weather forecasting. The new algorithm, which we call the "Ensemble Bred Vector" or EBV, is based on collective dynamics in essential ways. By construction, the EBV algorithm produces one or more dominant vectors. We investigate the performance of EBV, comparing it to the BV algorithm as well as the finite-time Lyapunov Vectors. We give a theoretical justification to the observed fact that the vectors produced by BV, EBV, and the finite-time Lyapunov vectors are similar for small amplitudes. Numerical comparisons of BV and EBV for the 3-equation Lorenz model and for a forced, dissipative partial differential equation of Cahn-Hilliard type that arises in modeling the thermohaline circulation, demonstrate that the EBV yields a size-ordered description of the perturbation field, and is more robust than the BV in the higher nonlinear regime. The EBV yields insight into the fractal structure of the Lorenz attractor, and of the inertial manifold for the Cahn-Hilliard-type partial differential equation.
description: Submitted to Monthly Weather Review
La orientación familiar como herramienta de resolución y prevención de conflictos
Creators: name: Latre, Yolanda
Publisher: name: Quaderns de Polítiques Familiars: Journal of Family Policies
Year: 2023

description: La complejidad cada vez mayor de todas aquellas cuestiones relacionadas con la familia y el desarrollo de sus diferentes ciclos vitales aparece en la génesis de la disciplina académica de la orientación familiar. En ella se habla de nuevos conceptos, de nuevas aplicaciones operativas y técnicas que puedan servir para afrontar los desequilibrios y las patologías que pueden originar a lo largo de la vida de una familia. En líneas generales se percibe falta de información sobre la labor de la orientación familiar, que aparece como una disciplina desconocida confundida con la mediación o la intervención terapéutica. Los servicios prestados por la orientación familiar pueden evitar la derivación de las problemáticas familiares no patologizadas al ámbito clínico, ya que su labor es previa al ámbito médico y farmacológico, siendo de base preventiva y global. Desde la experiencia profesional se constata cómo la colaboración de la orientación familiar puede reforzar aspectos algo más difíciles de abarcar en su totalidad en la atención socio-sanitaria actual, como la intervención en las crisis de los diferentes subsistemas -conyugal, parental, filial, fraternal, intergeneracional- contemplando dimensiones humanas constitutivas tan importantes como el contexto escolar, la familia extensa, y la monoparentalidad entre otros.
description: Quaderns de Polítiques Familiars: Journal of Family Policies, Núm. 8 (2022): Núm. 8: Un cambio de mirada ante el acompañamiento familiar
Classifications of good versus poor outcome following knee arthroplasty should not be defined using arbitrary criteria
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2020
Subjects: Knee
arthroplasty
outcome
pain
function

description: © 2020 The Author(s). A recently published paper by te Molder and colleagues in BMC Musculoskeletal Disorders confirmed prior reports indicating that definitions of good versus poor outcome cutoff scores for relevant knee arthroplasty outcomes including pain and function are heterogeneous and that this heterogeneity prevents generalizable inferences. In this Correspondence, we highlight an additional and, in our view, a more important problem with the substantial literature on this topic. There also is high homogeneity in that all studies relied on arbitrarily defined cutoff scores to differentiate good versus poor outcome. We discuss this problem and propose a method to avoid repeating the same problem in future studies designed to group patients into those with good versus those with poor outcome following knee arthroplasty.
title: Sulphur By-Product: A Potential Indicator of Early Dental Plaque-Induced Gingival Disease Activity
Creators: name: Pavolotskaya, Aleksandra
Publisher: name: Old Dominion University Libraries
Year: 2003

description: The purpose of this study was to determine the relationship between volatile sulfide
compounds and gingival health status, and to recognize if volatile sulfide compounds can
detect early dental plaque-induced gingival disease, using a 21-day experimental gingivitis
model. A split-mouth design with randomly selected quadrants of the mandibular arch
enabled 39 subjects, 19-62 years of age, to serve as their own controls. A baseline full-mouth
periodontal probing assessment was obtained to verify gingival health and enrollment status.
At baseline and at three subsequent appointments, gingival inflammation, bleeding on
probing, and sulfide levels were measured using the Gingival Index and the Diamond
Probe/Perio 2000 System®. For three weeks, subjects refrained from brushing and flossing
one randomly selected quadrant of the mandibular arch. The Pearson correlation test was
used to determine the relationship between sulfide levels and gingival health status. The
Wilcoxon matched-pairs signed rank test was used to compare the differences in gingival
inflammation, bleeding on probing and sulfide levels between the hygiene and non-hygiene
side at baseline, day 7, 14, and 21. Gingival Index, bleeding on probing and sulfide level
scores showed statistically significant differences from baseline until the end of the study
between both the hygiene and non-hygiene side, however, the strength of the correlation was
stronger for the non-hygiene side. The Diamond Probe/Perio 2000 System® was able to
detect sites with elevated sulfide levels, which suggest that volatile sulfide compounds may serve as a useful marker in detecting early dental plaque-induced gingivitis. Whether sulfur
by-product is a contributor to the disease process, or merely a correlate remains unanswered.
El sector privado como promotor del bienestar familiar integral: el caso del proyecto Impulsa
Creators: name: Navas, Natalia
name: Beresciuk, Carolina
Publisher: name: Quaderns de Polítiques Familiars: Journal of Family Policies
Year: 2023

description: La crisis social vivida en Chile a fines de 2019, y la pandemia de COVID-19 en marzo del 2020, visibilizan las vulnerabilidades que distintos segmentos de la población enfrentaban. Ambas crisis revelaron, que la vulnerabilidad que enfrenta un trabajador en su vida va más allá del ingreso o el salario porque pueden existir causas de desafección relacionadas con percepciones y situaciones personales y familiares que trascienden el vínculo laboral pero que lo afectan. En los albores de este escenario, en el segundo semestre de 2019, dos empresarios chilenos de sectores muy distintos entre sí -industria metalúrgica y cuidado de la salud- conscientes de esta situación, buscaron la forma de poder ir un paso más allá en la situación social de los trabajadores de sus organizaciones.
description: Quaderns de Polítiques Familiars: Journal of Family Policies, Núm. 8 (2022): Núm. 8: Un cambio de mirada ante el acompañamiento familiar
Get out! A Narrative Inquiry with Four Therapist who Practice Walk and Talk Therapy
Creators: name: Charbonneau, Tyla
Publisher: name: Graduate Studies
Year: 2016
Subjects: subject: Educational Psychology
subject: Education--Guidance and Counseling
subject: Education--Health
subject: Psychology
subject: FOS: Psychology
subject: Ecopsychology
subject: Therapy

description: There is a traditional idea that therapeutic conversations are best suited for office environments. Therapists are reconsidering this practice by taking clients outside into nature to reconnect with the world around them, get some exercise, and reflect on life problems in natural spaces. This study is a narrative inquiry into the experiences of four therapists who participate in walk and talk therapy as part of their therapeutic practice. Narrative inquirers attend to a three dimensional narrative inquiry space that includes temporality, sociality, and place located within stories of experience. Over a period of ten months, the therapists and I participated in conversations about their experiences with walk and talk therapy. This fieldwork resulted in four co-composed narrative accounts that represent each of their individual experiences. Across these four narrative accounts four narrative threads emerged: social complexities, connecting to a greater sense of the world, acknowledging the therapist, and innovation and creativity. Implications for practice, further conversations that are needed in the counselling profession about walk and talk therapy, and ideas for future research are also presented.
A graph convolutional network-based deep reinforcement learning approach for resource allocation in a cognitive radio network
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2020
Subjects: cognitive radio
interference mitigation
resource allocation
dynamic graph
graph convolutional network
deep reinforcement learning
end-to-end learning model

description: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Cognitive radio (CR) is a critical technique to solve the conflict between the explosive growth of traffic and severe spectrum scarcity. Reasonable radio resource allocation with CR can effectively achieve spectrum sharing and co-channel interference (CCI) mitigation. In this paper, we propose a joint channel selection and power adaptation scheme for the underlay cognitive radio network (CRN), maximizing the data rate of all secondary users (SUs) while guaranteeing the quality of service (QoS) of primary users (PUs). To exploit the underlying topology of CRNs, we model the communication network as dynamic graphs, and the random walk is used to imitate the users’ movements. Considering the lack of accurate channel state information (CSI), we use the user distance distribution contained in the graph to estimate CSI. Moreover, the graph convolutional network (GCN) is employed to extract the crucial interference features. Further, an end-to-end learning model is designed to implement the following resource allocation task to avoid the split with mismatched features and tasks. Finally, the deep reinforcement learning (DRL) framework is adopted for model learning, to explore the optimal resource allocation strategy. The simulation results verify the feasibility and convergence of the proposed scheme, and prove that its performance is significantly improved.
“Familya”, des maisons pour éduquer à la vie affective et relationnelle à tous les âges de la vie
Creators: name: Veyron La Croix, Thierry
Publisher: name: Quaderns de Polítiques Familiars: Journal of Family Policies
Year: 2023

description: Différentes études ont mis en évidence que d’un côté la famille est la première valeur des Français, loin devant le travail, la réussite sociale ou les loisirs ; et de l’autre que la famille est extrêmement fragilisée, avec un taux de séparation qui n’a cessé de croître depuis 50 ans. Fort de ce constat, une première maison Familya a ouvert ses portes à Lyon, pour prendre soin du couple, des relations intrafamiliales. A partir de cette expérience de terrain, les besoins des personnes ont été mieux cernés. La maison s’est enrichie de nombreuses propositions pour répondre à un objectif : éduquer à la relation à tous les âges de la vie, avec un focus particulier sur la prévention des ruptures conjugales et le soutien à la parentalité. Sollicitée par de nombreuses autres villes souhaitant se doter d’une maison similaire, une fédération Familya a été créée, afin d’accompagner les équipes voulant créer une maison dans leur ville. D’autre part, afin d’objectiver sa démarche, Familya a commandité une étude d’impact social, pour mesurer les effets de l’accompagnement des couples en conseil conjugal, tant sur la trajectoire des couples que sur les finances publiques. Cette étude a montré que 73% des couples venus en conseil conjugal avec l’intention probable de se séparer ont restauré une relation de qualité. D’autre part, 76% des couples qui ont pris la décision de se séparer estiment que le conseil conjugal a permis une séparation apaisée et moins conflictuelle. Enfin, 1€ dépensé pour soutenir le conseil conjugal permet une économie de 5 à 11€ pour la collectivité dans les 5 années qui suivent. Une partie de cette étude est reproduite en synthèse dans cet article.
description: Quaderns de Polítiques Familiars: Journal of Family Policies, Núm. 8 (2022): Núm. 8: Un cambio de mirada ante el acompañamiento familiar
Heavy fields, reduced speeds of sound and decoupling during inflation
Creators: name: Achucarro, Ana
name: Atal, Vicente
name: Cespedes, Sebastian
name: Gong, Jinn-Ouk
name: Palma, Gonzalo A.
name: Patil, Subodh P.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We discuss and clarify the validity of effective single field theories of inflation obtained by integrating out heavy degrees of freedom in the regime where adiabatic perturbations propagate with a suppressed speed of sound. We show by construction that it is indeed possible to have inflationary backgrounds where the speed of sound remains suppressed and slow-roll persists for long enough. In this class of models, heavy fields influence the evolution of adiabatic modes in a manner that is consistent with decoupling of physical low and high energy degrees of freedom. We emphasize the distinction between the effective masses of the isocurvature modes and the eigenfrequencies of the propagating high energy modes. Crucially, we find that the mass gap that defines the high frequency modes increases with the strength of the turn, even as the naive heavy (isocurvature) and light (curvature) modes become more strongly coupled. Adiabaticity is preserved throughout, and the derived effective field theory remains in the weakly coupled regime, satisfying all current observational constraints on the resulting primordial power spectrum. In addition, these models allow for an observably large equilateral non-Gaussianity.
description: 8 pages, v2: minor changes, typos corrected
Acompañamiento parental en entornos desafiantes: La experiencia del programa PASOS UANDES
Creators: name: Reyes Brito, Javiera
name: Tarud Aravena, Claudia
Publisher: name: Quaderns de Polítiques Familiars: Journal of Family Policies
Year: 2023

description: El Programa de Acompañamiento Parental PASOS UANDES es una instancia de reflexión en que madres y padres construyen su proyecto educativo familiar y trabajan temáticas según ciclos de la vida. La elaboración del proyecto da sentido a la vida personal y familiar, sirve de ruta, fortalece los valores y lleva a los miembros de la familia a proponerse metas y cumplirlas. El Programa promueve la reflexión y el pensamiento crítico, así como el desarrollo de competencias parentales, la autoeficacia y la prevención del estrés familiar. El programa se despliega en base de un diagnóstico de la realidad sociocultural de cada familia y comunidad y es consistente con una continua revisión de literatura científica y experiencias exitosas a nivel mundial. Estas instancias se desarrollan individualmente o bien en grupos pequeños de familias y muestran una alta participación y satisfacción. PASOS Parentalidad se implementa en Colegios como parte del Programa PASOS UANDES de formación de carácter, afectividad y sexualidad. El año 2021 el Programa de acompañamiento parental se aplicó en siete escuelas, con un total de 1.398 sesiones con un alto nivel de satisfacción de usuarios. Además, se levantó una línea base a través de instrumentos validados sobre autoeficacia, competencias y estrés parental para medir su impacto a lo largo del tiempo.
description: Quaderns de Polítiques Familiars: Journal of Family Policies, Núm. 8 (2022): Núm. 8: Un cambio de mirada ante el acompañamiento familiar
The Phase Behavior of Heavy Oil and Propane Mixtures
Creators: name: Mancilla Polanco, Adel Alberto
Publisher: name: Graduate Studies
Year: 2017
Subjects: subject: Engineering--Chemical
subject: Engineering--Petroleum
subject: heavy oil
subject: propane
subject: pitch
subject: onset
subject: yield
subject: cubic equation of state

description: The phase behavior of propane diluted bitumen was mapped from temperatures between 20 and 180°C and pressures up to 10 MPa. Both vapor-liquid (VL) and liquid-liquid (LL) regions were observed. High pressure micrographs demonstrated that the heavy phase (a pitch phase) transitioned from a glass to a liquid state with increased temperature and feed propane content. Pressure-temperature and pressure-composition phase diagrams were constructed from saturation pressure and pitch phase onset data. The amount and composition of the heavy phase was also measured. Solvent-free pitch yields as high as 70 wt% of the bitumen were observed. Pseudo-ternary diagrams were also constructed to observe the partitioning of the species between the phases. Finally, the ability of a cubic equation-of-state with two forms of mixing rules were explored to model the data. The results can be used in the design of in situ and surface processes involving the addition of propane to bitumen.
La Naprotecnología, un modo de acompañar la infertilidad
Creators: name: Carrión Armero, Venancio
Publisher: name: Quaderns de Polítiques Familiars: Journal of Family Policies
Year: 2023

description: Ante el aumento de parejas infértiles habitualmente se plantea un camino que lleva a las técnicas de reproducción asistida. Sin embargo, existe otra opción que prioriza diagnosticar las causas, tanto en el hombre como en la mujer, y que busca restaurar la fertilidad. Esta vía además de mejorar la salud, puede facilitar la llegada del hijo esperado sin entrar en el debate moral que presentan las técnicas de reproducción. Los métodos naturales de reconocimiento de la fertilidad son un aliado en el estudio médico de esta situación. En España existe la Asociación NAPROTEC, que acompaña de manera integral en todo este proceso, partiendo de la situación matrimonial, pasando por el aprendizaje del método natural y llegando a los médicos que facilitarán el diagnóstico.
description: Quaderns de Polítiques Familiars: Journal of Family Policies, Núm. 8 (2022): Núm. 8: Un cambio de mirada ante el acompañamiento familiar
El papel de las asociaciones familiares en Europa
Creators: name: Speranza, Nicola
Publisher: name: Quaderns de Polítiques Familiars: Journal of Family Policies
Year: 2023

description: “No es bueno que el hombre esté solo” (Génesis, 2,18). Tampoco es bueno que las familias estén solas; aislada como una mónada, “las familias necesitan salir de sí mismas, necesitan dialogar y encontrarse con los demás, para construir una unidad que no sea uniformidad y que pueda generar progreso y promover el bien común”1. Para responder a esta necesidad las redes familiares necesitan determinar una agenda, un marco de ayuda y de acción mutua. Aquellas que son de inspiración católicas, al estar unidas a los pastores, tienen además la fuerza del anuncio evangélico.
description: Quaderns de Polítiques Familiars: Journal of Family Policies, Núm. 8 (2022): Núm. 8: Un cambio de mirada ante el acompañamiento familiar
Remote Sensing of Understory Plant Phenology: A Framework for Monitoring and Projecting the Impacts of Climate Change
Creators: name: Laskin, David
Publisher: name: Graduate Studies
Year: 2017
Subjects: subject: Forestry and Wildlife
subject: Ecology
subject: FOS: Biological sciences
subject: Remote Sensing
subject: Vegetation Phenology

description: Phenology is an integrative environmental science used to examine recurring biological events in nature. The emphasis is in observing recurring plant and animal life cycle stages, especially their timing and relationship with weather and climate. Examples include wildlife migrations, spawning, or the flowering and fruiting of plants. At higher latitudes, temperature has strong physiological control over rates of vegetation development. Variability in seasonal temperature can therefore influence the timing of vegetation phenology and all of the interrelated ecosystem processes that rely on it. Shifts in phenology are one of the first observed impacts of climate change. Increasing temperatures are advancing the timing of spring onset which in turn alters species movement and interactions, increasing the risk of trophic mismatches. Satellite remote sensing provides an efficient means of uncovering broad-scale phenology patterns, however monitoring the comprehensive development of an individual plant species remains a significant challenge. These complexities are exacerbated in forest ecosystems due to interference from overstory canopies on the remote detection of understory vegetation. This research exploits the physiological nexus between plants and temperature as a window through which understory phenology can be observed. A framework was developed to produce daily maps of understory plant phenology using satellite-derived estimates of understory air temperature. It examines the scales at which phenological relationships operate and how they vary in space and time in the southern Rocky Mountains of Canada. It also explores the projected impacts of climate change on phenological timing through mapped scenarios and experimental warming in climate-controlled growth chambers. The framework provides global extensibility to monitor intra- and interannual phenology patterns for any species with distinct seasonal phenology; providing near-real-time ecosystem monitoring for a dynamic alternative to traditionally static, niche-based approaches of environmental modeling.
Decision Making in Patients with Anorexia Nervosa: a Bioethical and Methodological Challenge
Creators: name: Ramos Pozón, Sergio
name: Robles Del Olmo, Bernabé
name: Sevilla Guerra, Sonia
Publisher: name: Ramon Llull Journal of Applied Ethics
Year: 2022

description: The refusal of patients with anorexia to undergo medical treatment may create strong ethical dilemmas for health professionals, obliging them either to accept decisions that leave patients at risk or to apply treatment against their patients’ will. In this paper we discuss the issue of mental capacity in patients with anorexia who consent to or refuse a specific treatment. We also review personal identity as an important factor in decision-making and discuss three decision-making styles: the subjective criterion, substituted judgment, and the best interest principle, and highlight the serious challenges associated with each one.
description: Ramon Llull Journal of Applied Ethics, Vol. 1, Núm. 13 (2022): Issue 13
P53-regulated miR-320a targets PDL1 and is downregulated in malignant mesothelioma
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2020

description: © 2020, The Author(s). Malignant pleural mesothelioma (MPM) is an aggressive cancer, related to asbestos exposure, which has a dismal prognosis. MPM diagnosis is late and often challenging, suggesting the need to identify more reliable molecular biomarkers. Here, we set out to identify differentially expressed miRNAs in epithelioid, biphasic, and sarcomatoid MPMs versus normal mesothelium and explored specific miRNA contribution to mesothelial tumorigenesis. We screened an LNA™-based miRNA-microrray with 14 formalin-fixed paraffin-embedded (FFPE) MPMs and 6 normal controls. Through real-time qRT-PCR we extended the analysis of a miRNA subset and further investigated miR-320a role through state-of-the-art techniques. We identified 16 upregulated and 32 downregulated miRNAs in MPMs versus normal tissue, including the previously identified potential biomarkers miR-21, miR-126, miR-143, miR-145. We showed in an extended series that miR-145, miR-10b, and miR-320a levels can discriminate tumor versus controls with high specificity and sensitivity. We focused on miR-320a because other family members were found downregulated in MPMs. However, stable miR-320a ectopic expression induced higher proliferation and migration ability, whereas miR-320a silencing reduced these processes, not supporting a classic tumor-suppressor role in MPM cell lines. Among putative targets, we found that miR-320a binds the 3′-UTR of the immune inhibitory receptor ligand PDL1 and, consistently, miR-320a modulation affects PDL1 levels in MPM cells. Finally, we showed that p53 over-expression induces the upregulation of miR-320a, along with miR-200a and miR-34a, both known to target PDL1, and reduces PDL1 levels in MPM cells. Our data suggest that PDL1 expression might be due to a defective p53-regulated miRNA response, which could contribute to MPM immune evasion or tumorigenesis through tumor-intrinsic roles.
Autonomy, Monomania and free Development of Personality in the clinical Relationship. To What Extent can the Autonomous Person be Protected?
Creators: name: Vergara, Oscar
Publisher: name: Ramon Llull Journal of Applied Ethics
Year: 2022

description: Abstract: All competent moral agents have a prima facie right to make their own health decisions. When this competence is lacking, they cease to be autonomous and someone else may justifiably make decisions for them in an act of soft paternalism that is generally admitted. The problem arises when autonomous subjects need to be protected (from themselves). This type of protection only tends to be admitted in very exceptional cases, such as suicide attempts, as a form of hard paternalism. So the question arises as to whether and to what extent this protection can be extended to certain cases in which the autonomous and competent moral agent acts according to an uncommonly singular life plan. To answer this question, we deemed it important to distinguish between freedom and autonomy, for which purpose we have adopted a eudaimonic approach.
description: Ramon Llull Journal of Applied Ethics, Vol. 1, Núm. 13 (2022): Issue 13
Mass sum rules of the electron in quantum electrodynamics
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2020
Subjects: Precision QED
Renormalization Regularization and Renormalons

description: © 2020, The Author(s). Different decompositions of the nucleon mass, in terms of the masses and energies of the underlying constituents, have been proposed in the literature. We explore the corresponding sum rules in quantum electrodynamics for an electron at one-loop order in perturbation theory. To this aim we compute the form factors of the energy-momentum tensor, by paying particular attention to the renormalization of ultraviolet divergences, operator mixing and scheme dependence. We clarify the expressions of all the proposed sum rules in the electron rest frame in terms of renormalized operators. Furthermore, we consider the same sum rules in a moving frame, where they become energy decompositions. Finally, we discuss some implications of our study on the mass sum rules for the nucleon.
Maritime Paleoindian technology, subsistence, and ecology at an ~11,700 year old Paleocoastal site on California's Northern Channel Islands, USA
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2020
Subjects: subject: Animals
subject: Aquatic Organisms
subject: Archaeology
subject: Ecology
subject: FOS: Biological sciences
subject: History, Medieval
subject: Humans
subject: Pacific Ocean
subject: Paleontology
subject: Population Dynamics
subject: Seafood
subject: Technology

description: Copyright: © This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. During the last 10 years, we have learned a great deal about the potential for a coastal peopling of the Americas and the importance of marine resources in early economies. Despite research at a growing number of terminal Pleistocene archaeological sites on the Pacific Coast of the Americas, however, important questions remain about the lifeways of early Paleocoastal peoples. Research at CA-SRI-26, a roughly 11,700 year old site on California's Santa Rosa Island, provides new data on Paleoindian technologies, subsistence strategies, and seasonality in an insular maritime setting. Buried beneath approximately two meters of alluvium, much of the site has been lost to erosion, but its remnants have produced chipped stone artifacts (crescents and Channel Island Amol and Channel Island Barbed points) diagnostic of early island Paleocoastal components. The bones of waterfowl and seabirds, fish, and marine mammals, along with small amounts of shellfish document a diverse subsistence strategy. These data support a relatively brief occupation during the wetter “winter” season (late fall to early spring), in an upland location several km from the open coast. When placed in the context of other Paleocoastal sites on the Channel Islands, CA-SRI-26 demonstrates diverse maritime subsistence strategies and a mix of seasonal and more sustained year-round island occupations. Our results add to knowledge about a distinctive island Paleocoastal culture that appears to be related to Western Stemmed Tradition sites widely scattered across western North America.
Investigation into the Natural History of Pseudomonas aeruginosa and the Lung Microbiome of Non-Cystic Fibrosis Bronchiectasis Patients
Creators: name: Woo, Taylor
Publisher: name: Graduate Studies
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Epidemiology
subject: Pseudomonas aeruginosa
subject: Non-Cystic Fibrosis Bronchiectasis
subject: Microbiome

description: Non-cystic fibrosis bronchiectasis (nCFB) represents an orphan disease with much of our understanding of the natural history and microbial adaptation derived from studies performed in cystic fibrosis (CF). Findings from such studies are inferred to hold true to nCFB with little supporting evidence. Importantly, in nCFB patients comparatively little is known about the natural history and pathoadaptation of Pseudomonas aeruginosa, the archetypal lung pathogen, nor the potential role of the lung microbiome in disease. By challenging preconceived notions about nCFB, we identified many similarities and notable differences in the natural history, epidemiology, and virulence adaptations of P. aeruginosa infections between nCFB and CF-derived P. aeruginosa isolates. Furthermore, by characterizing a collection of longitudinally collected sputum samples, we found that the microbiome is diverse and generally unique to each individual. We observed the microbial community to be relatively stable over time but independent of disease state and acute exacerbation events.