cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Liminal blankness : mixing race and space in monochrome's psychic surface
Creators: name: Morrison, Angeline Dawn
Publisher: name: University of Plymouth
Year: 2002

description: Merged with duplicate record 10026.1/2008 on 28.02.2017 by CS (TIS)
description: Blank space in western Art History and visual culture is something that has tended to be either explained away, or ignored. Pictures that do not depict challenge the visual basis of the ego and its others, confronting what I call the `Phallic reader' (who sees according to the logic and rules of the Phallogocentric system he inhabits) and potentially disturbing his sense of the visible. The Phallic reader, the visible and the seeing ego's sense of how to see, meet in what I call the `psychic surface'. Deploying this notion of a `psychic surface' allows for readings which move on from the potentially confining logic of the Phallus. Paradoxically, the psychic structure of monochrome's liminal blankness is homologous to the indeterminate Mixed Race subject, whose body transgresses not only the foundational historical binarism of `Black/White', but also Lacanian psychoanalysis. This thesis aims to concentrate on exploring blank spaces, with particular reference to the monochrome within western Art History. Building on the considerable work since at least the 1960s that critiques the binary logocentrism of Eurocentric, Hegelian-originated Art History, this thesis aims to explore the specific ways monochrome evades, undermines and tricks commonly accepted `groundrules' of Art History. The Phallic reader is severely restricted in understanding that which falls outside of the signifying logic of a particular system of Art History that follows a binary, teleological and Phallogocentric course. Both monochrome and the Mixed Race subject fall outside of this logic, as both contain the structure of the trick. In each case, the trick is activated in the tension between the prychica nd the opticals urfaces. I suggestt hat monochrome's psychic space is pre-Phallic, a space of eternal deferral of meaning, a space that playfully makes a nonsense of binary structures. Psychoanalysis is largely used here as an analytic tool, but also appears as an object of critique. Art History provides an anchor for the optical surfaces under discussion. Theories of `radical superficiality' both contradict and complement these ways of theorising the psychic surface. The trick/ster is a significant/signifiant means of deploying interdisciplinary methodologies to negotiate this difficult terrain between Black, White and monochrome. An interdisciplinary approach also enacts the psychic structure of indeterminacy of my objects of study. I hope that by proposing a potential transgressive power for those indeterminate things that continue to confound the binary systems that aim to contextualise and confine them, I will contribute to the areas of Visual Culture and `Race' Theory.
Use of an augmented reality sand table for satellite remote sensing education
Creators: name: O’Banion, Matthew S.
name: Lewis, Nicholas S.
name: Boyce, Michael W.
name: Laughlin, Jordan
name: Majkowicz, Deborah C.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Plant Biology
subject: FOS: Biological sciences

description: This experiment utilized advanced visualization technology for the delivery of an introductory remote sensing lesson in an undergraduate geography course. Given the numerous immersive visualization solutions available, it is now possible to leverage the capabilities of augmented, mixed, and virtual reality (AR, MR, and VR) technology in a classroom learning environment. For instructors, it is important to understand how advanced visualization technologies can enhance the learning experience and enable greater knowledge retention. To validate the use of an AR sand table/sandbox in a group academic setting, approximately 400 participants were evaluated to assess the impact on students’ retention of both foundational and practical remote sensing concepts. This work represents a between-subjects design with two AR sand table experimental groups (instructor sand table interaction, and student sand table interaction) and one control group with no sand table exposure. The use of the AR sand table in a classroom environment was found to improve retention of foundational remote sensing knowledge and elevate the assessment performance for subjects identified as lower performers.
title: Thyroid T2 value increase in patients with hypothyroidism
Creators: name: Liu, Min
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Tissue characterisation
subject: Technology assessment
subject: MR
subject: Head and neck

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Recent developments in MR imaging techniques currently provide clinically-feasiblemappingof T1 andT2relaxation times, thus providing a quantitative assessment of the parameters of interest. Myocardial edema can be evaluated...
Expression of Six1 in luminal breast cancers predicts poor prognosis and promotes increases in tumor initiating cells by activation of extracellular signal-regulated kinase and transforming growth factor-beta signaling pathways
Creators: name: Harrell, J Chuck
Publisher: name: BioMed Central Ltd
Year: 2012

description: Abstract Introduction Mammary-specific overexpression of Six1 in mice induces tumors that resemble human breast cancer, some having undergone epithelial to mesenchymal transition (EMT) and exhibiting stem/progenitor cell features. Six1 overexpression in human breast cancer cells promotes EMT and metastatic dissemination. We hypothesized that Six1 plays a role in the tumor initiating cell (TIC) population specifically in certain subtypes of breast cancer, and that by understanding its mechanism of action, we could potentially develop new means to target TICs. Methods We examined gene expression datasets to determine the breast cancer subtypes with Six1 overexpression, and then examined its expression in the CD24low/CD44+ putative TIC population in human luminal breast cancers xenografted through mice and in luminal breast cancer cell lines. Six1 overexpression, or knockdown, was performed in different systems to examine how Six1 levels affect TIC characteristics, using gene expression and flow cytometric analysis, tumorsphere assays, and in vivo TIC assays in immunocompromised and immune-competent mice. We examined the molecular pathways by which Six1 influences TICs using genetic/inhibitor approaches in vitro and in vivo. Finally, we examined the expression of Six1 and phosphorylated extracellular signal-regulated kinase (p-ERK) in human breast cancers. Results High levels of Six1 are associated with adverse outcomes in luminal breast cancers, particularly the luminal B subtype. Six1 levels are enriched in the CD24low/CD44+ TIC population in human luminal breast cancers xenografted through mice, and in tumorsphere cultures in MCF7 and T47D luminal breast cancer cells. When overexpressed in MCF7 cells, Six1expands the TIC population through activation of transforming growth factor-beta (TGF-β) and mitogen activated protein kinase (MEK)/ERK signaling. Inhibition of ERK signaling in MCF7-Six1 cells with MEK1/2 inhibitors, U0126 and AZD6244, restores the TIC population of luminal breast cancer cells back to that observed in control cells. Administration of AZD6244 dramatically inhibits tumor formation efficiency and metastasis in cells that express high levels of Six1 ectopically or endogenously. Finally, we demonstrate that Six1 significantly correlates with phosphorylated ERK in human breast cancers. Conclusions Six1 plays an important role in the TIC population in luminal breast cancers and induces a TIC phenotype by enhancing both TGF-β and ERK signaling. MEK1/2 kinase inhibitors are potential candidates for targeting TICs in breast tumors.
title: Adult T-cell leukemia/lymphoma diagnosed using PET/CT
Creators: name: Hayasaka, Kazumasa
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Lymphoma
subject: Molecular imaging
subject: PET-CT
subject: Oncology

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The purpose of this study was to describe the features of adult T-cell leukemia/lymphoma (ATLL) using...
Estimation of genetic parameters for growth in a population of Eucalyptus grandis × Eucalyptus nitens hybrids in KwaZulu-Natal and Mpumalanga
Creators: name: Brink, W
name: van den Berg, G
name: Nel, A
name: du Toit, B
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: Hybridising Eucalyptus grandis with Eucalyptus nitens produces progeny intended to combine the favourable traits of both parents. E. grandis exhibits good growth, stem form, wood properties and rooting ability for vegetative propagation. E. nitens displays superior cold tolerance, including superior frost and snow tolerance, and high wood density. Eucalypt hybrids developed specifically for improved cold tolerance tend to produce fewer viable hybrid progeny and are more recalcitrant rooters than their sub-tropical counterparts. To overcome these challenges, a novel testing strategy was developed and used to identify promising varieties for commercial deployment. As a result, a large population of E. grandis × E. nitens hybrids was developed through controlled pollinations, propagated via mini-cuttings and established in a total of 21 field trials, across the KwaZulu-Natal and Mpumalanga provinces of South Africa, to investigate growth and adaptability. Data of three growth traits, namely diameter at breast height (DBH), total tree height and volume were analysed to determine the genetic parameters of these traits. Combined-site broad sense heritability for DBH, height and volume were 0.39, 0.46 and 0.35 respectively, indicating a moderate level of genetic control. This, in conjunction with large genetic coefficients of variation (CVg = 20%, 16% and 41% for DBH, height and volume respectively) shows that substantial gains can be made through selection. Combined-site Type B genetic correlations for DBH, height and volume were 0.71, 0.68 and 0.65 respectively, indicating that there was notable genotype by environment interaction. Pairwise comparisons of rBg for volume showed large variation in the correlations of clonal rankings between trials, with rBg ranging from 0.0 to 0.90.
On $P$-adic Ising-Vannimenus model on an arbitrary order Cayley tree
Creators: name: Mukhamedov, Farrukh
name: Saburov, Mansoor
name: Khakimov, Otabek
Publisher: name: arXiv
Year: 2015
Subjects: subject: Dynamical Systems (math.DS)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 82B26, 46S10, 12J12, 39A70, 47H10, 60K35

description: In this paper, we continue an investigation of the $p$-adic Ising-Vannimenus model on the Cayley tree of an arbitrary order $k$ $(k\geq 2$). We prove the existence of $p$-adic quasi Gibbs measures by analyzing fixed points of multi-dimensional $p$-adic system of equations. We are also able to show the uniqueness of translation-invariant $p$-adic Gibbs measure. Finally, it is established the existence of the phase transition for the Ising-Vannimenus model depending on the order $k$ of the Cayley tree and the prime $p$. Note that the methods used in the paper are not valid in the real setting, since all of them are based on $p$-adic analysis and $p$-adic probability measures.
description: 23 pages, 1 figure
title: Материалы к истории формирования древнерусских денежно-весовых систем
Creators: name: Купранис, А. А.
Publisher: name: Реноме
Year: 2022

description: Издание посвящено исследованию формирования древнерусских денежно-весовых систем. Рассмотрен ряд раннесредневековых метрологических артефактов, а также относящиеся к истории денежно-весовых систем Древней Руси, Ближнего Востока и Западной Европы свидетельства нарративных источников. Предпринята попытка связать русские счётно-весовые единицы — гривны с определёнными типами раннесредневековых гирь.
Книга предназначена для нумизматов, историков, метрологов, коллекционеров и всех любителей памятников древности.
It’s a long shot, but it just might work! Perspectives on the future of medicine
Creators: name: Basch, Ethan
Publisher: name: BioMed Central
Year: 2016

description: Abstract What does the future of medicine hold? We asked six researchers to share their most ambitious and optimistic views of the future, grounded in the present but looking out a decade or more from now to consider what’s possible. They paint a picture of a connected and data-driven world in which patient value, patient feedback, and patient empowerment shape a continually learning system that ensures each patient’s experience contributes to the improved outcome of every patient like them, whether it be through clinical trials, data from consumer devices, hacking their medical devices, or defining value in thoughtful new ways.
title: PET/CT hypermetabolism in the musculoskeletal system- metastases and beyond
Creators: name: Zlatareva, Dora
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Musculoskeletal bone
subject: PET-CT
subject: Diagnostic procedure
subject: Metastases
subject: Trauma

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: 1. To review the most common hypermetabolic PET/CT findings of the musculoskeletal system, 2. To discuss the differentiation between benign and malignant lesions in bones and...
On the origin of the correlations between the accretion luminosity and emission line luminosities in pre-main sequence stars
Creators: name: Mendigutía, I.
name: Oudmaijer, R. D.
name: Rigliaco, E.
name: Fairlamb, J. R.
name: Calvet, N.
name: Muzerolle, J.
name: Cunningham, N.
name: Lumsden, S. L.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Correlations between the accretion luminosity and emission line luminosities (L_acc and L_line) of pre-main sequence (PMS) stars have been published for many different spectral lines, which are used to estimate accretion rates. Despite the origin of those correlations is unknown, this could be attributed to direct or indirect physical relations between the emission line formation and the accretion mechanism. This work shows that all (near-UV/optical/near-IR) L_acc-L_line correlations are the result of the fact that the accretion luminosity and the stellar luminosity (L_star) are correlated, and are not necessarily related with the physical origin of the line. Synthetic and observational data are used to illustrate how the L_acc-L_line correlations depend on the L_acc-L_star relationship. We conclude that because PMS stars show the L_acc-L_star correlation immediately implies that L_acc also correlates with the luminosity of all emission lines, for which the L_acc-L_line correlations alone do not prove any physical connection with accretion but can only be used with practical purposes to roughly estimate accretion rates. When looking for correlations with possible physical meaning, we suggest that L_acc/L_star and L_line/L_star should be used instead of L_acc and L_line. Finally, the finding that L_acc has a steeper dependence on L_star for T-Tauri stars than for intermediate-mass Herbig Ae/Be stars is also discussed. That is explained from the magnetospheric accretion scenario and the different photospheric properties in the near-UV.
description: 9 pages, 5 figures, 2 tables. Accepted in MNRAS
An improved isolated DC–DC Buck converter with high step-down ratio
Creators: name: Mohebalizadeh, Hadi
name: Babaei, Ebrahim
name: Sabahi, Mehran
name: Mohammadian, Leila
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: Please replcae the abstract with the following text:In this paper, a new isolated high step-down dc-dc topology based on buck converter is proposed. This structure reduces the amplitude of the voltage on the primary side of the transformer (which is an ideal type), which reduces the turn-ratio and leakage impedance. The recommended structure uses active clamped strategies to return the energy of leakage impedance and to repress voltage spikes. Under this condition, the overall efficiency of the converter can be enhanced impressively. The benefits of the proposed structure are simple structure, a simple control system that needs only two signals with a 180O phase shift, reduced power circuit components, the lower standing voltage of the semiconductor components in the high-voltage side, and a high conversion ratio. The proposed converter can be applied in low voltage (5V) applications with high input current such as computer applications. The operation modes of the recommended converter, designing of utilized circuit elements, steady condition analysis, and finally some experimental results of the built prototype of the recommended structure have been provided completely. The overall efficiency of the proposed topology at 250W is equal to 92%. Also, the amplitudes of input and output voltage are 380 V and 5 V, respectively.
Multiple paxillin binding sites regulate FAK function
Creators: name: Gao, Guanghua
name: Schaller, Michael D.
name: Rajfur, Zenon
name: Scheswohl, Danielle M
name: Campbell, Sharon
name: Harrell, Jessica R
Publisher: name: BioMed Central Ltd
Year: 2008

description: Abstract Background FAK localization to focal adhesions is essential for its activation and function. Localization of FAK is mediated through the C-terminal focal adhesion targeting (FAT) domain. Recent structural analyses have revealed two paxillin-binding sites in the FAT domain of FAK. To define the role of paxillin binding to each site on FAK, point mutations have been engineered to specifically disrupt paxillin binding to each docking site on the FAT domain of FAK individually or in combination. Results These mutants have been characterized and reveal an important role for paxillin binding in FAK subcellular localization and signaling. One paxillin-binding site (comprised of α-helices 1 and 4 of the FAT domain) plays a more prominent role in localization than the other. Mutation of either paxillin-binding site has similar effects on FAK activation and downstream signaling. However, the sites aren't strictly redundant as each mutant exhibits phosphorylation/signaling defects distinct from wild type FAK and a mutant completely defective for paxillin binding. Conclusion The studies demonstrate that the two paxillin-binding sites of FAK are not redundant and that both sites are required for FAK function.
title: Diffusion-weighted MRI of whole body: artifacts and pitfalls
Creators: name: Gelezhe, Pavel
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Artifacts
subject: Molecular imaging
subject: MR-Diffusion/Perfusion
subject: Molecular imaging

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The role of whole body diffusion-weighted imaging (WB DWI) in oncology is increasing. We discuss main pitfalls in WB DWI interpretation and how to avoid...
Chromatin disruption in the promoter of Bovine Leukemia Virus during transcriptional activation - Additional Files
Creators: name: Van Lint, Carine
Publisher: name: Zenodo
Year: 2023

description: Additional information for Colin et al. (2011) Chromatin disruption in the promoter of Bovine Leukemia Virus during transcriptional activation published in Nucleic Acids Research Volume 39, Issue 22 doi:10.1093/nar/gkr671, requested by a anonymous whistleblower. A description of the individual files can be found in the README.txt file
A multidisciplinary modeling system for aircraft structural components
Creators: name:  TOBIE VAN DEN BERG
name:   BAS VAN MANEN
name:   TON VAN DER LAAN
name:   IOANA CIOBOTIA
name:   DARPAN BANSAL
name:   JENTE SONNEVELD
Publisher: name: Proceedings of the Aerospace Europe Conference - EUCASS - CEAS - 2023
Year: 2023
Subjects: MDO
KBE
STRUCTURAL DESIGN
DESIGN AUTOMATION
TRADE STUDIES
MULTIDISCIPLINARY MODELS

description: This paper describes the development of a Multidisciplinary Modelers (MDM) package. This is a python based software package used in trade studies and optimizations of aircraft components. It is capable of modelling wing-like aircraft components such swings, movables and flaps. It also provides data for and links to analysis tools that determines the performance of such aircraft components. These analyses are for example finite element analyses, stress analysis and manufacturing cost analyses. The NIDM enables full automation of the engineering process as is shown in the application cases included in this paper.
Training the next generation of physician researchers – Vanderbilt Medical Scholars Program
Creators: name: Islam, Jessica Y
Publisher: name: BioMed Central
Year: 2018

description: Abstract Background As highlighted in recent reports published by the Physician-Scientist Workforce Working Group at the National Institutes of Health, the percentage of physicians conducting research has declined over the past decade. Various programs have been put in place to support and develop current medical student interest in research to alleviate this shortage, including The Vanderbilt University School of Medicine Medical Scholars Program (MSP). This report outlines the long-term program goals and short-term outcomes on career development of MSP alumni, to shed light on the effectiveness of research training programs during undergraduate medical training to inform similar programs in the United States. Methods MSP alumni were asked to complete an extensive survey assessing demographics, accomplishments, career progress, future career plans, and MSP program evaluation. Results Fifty-five (81%) MSP alumni responded, among whom 12 had completed all clinical training. The demographics of MSP alumni survey respondents are similar to those of all Vanderbilt medical students and medical students at all other Association of American Medical College (AAMC) medical schools. MSP alumni published a mean of 1.9 peer-reviewed manuscripts (95% CI:1.2, 2.5), and 51% presented at national meetings. Fifty-eight percent of respondents reported that MSP participation either changed their career goals or helped to confirm or refine their career goals. Conclusions Results suggest that the MSP program both prepares students for careers in academic medicine and influences their career choices at an early juncture in their training. A longer follow-up period is needed to fully evaluate the long-term outcomes of some participants.
Doublecloth: History, Technique, Possibilities.
Creators: name: Bell, Diane Marjorie
Publisher: name: University of Plymouth
Year: 1995

description: Merged with duplicate record 10026.1/2320 on 06.20.2017 by CS (TIS)
description: The aim of this research is to analyse through practical and historical investigation the manner in which Doublecloth in the twentieth century has been transformed from a traditional woven technique to one of artistic innovation and challenge. The first series of woven samples and historic enquiry concerns the structure and pattern of doublecloth at a time when its industrial and craft-based use was for the production of decorative and utilitarian woven fabrics. The research focuses on the extent to which this technique was given aesthetic credibility by its altered profile at the Bauhaus and the subsequent influence of the writings and work of Anni Albers. While the philosophy and products of the Bauhaus and the role of Walter Gropius have been documented and widely debated the practice of textiles, and the influence on it of gender, class and the hierarchical practice of craft, has received little critical attention. The research seeks to redress this imbalance, evaluating why the output of the textile workshops was undervalued artistically and considered marginal to the products from other workshops. This leads to a consideration of the interface between the practice of Fine Art and the practice of Craft, between designing and making, between art and industry. The woven samples are a process of experimentation against which the historic stages can be tested and the technical constraints of contemporary practice can be explained. This primary material leads to a consideration of the new technology and the impact of Nuno doublecloth fabrics on the production of doublecloth for the mass market. The evidence suggests that while new fabric finishes and experimental pattern effects are desirable, the difficulties of hand production are so prohibitive, that it is only with computer aided technology that such ambitions can be met
title: The role of diagnostic imaging in the prosthetic knee: pre-operative planning, study of complications, and follow up
Creators: name: Argento, Giuseppe
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Musculoskeletal bone
subject: Musculoskeletal joint
subject: Digital radiography
subject: CT
subject: MR
subject: Cost-effectiveness
subject: Arthritides

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: In the pre-operative study of patients with severe osteoarthritis of the knee and with indication for arthroplasty, a radiographic evaluation and an MRI study or a CT scan are often requested. The aim of our study is to define appropriateness...
Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis
Creators: name: Bolik, Julia
name: Krause, Freia
name: Stevanovic, Marija
name: Gandraß, Monja
name: Thomsen, Ilka
name: Schacht, Sarah-Sophie
name: Rieser, Eva
name: Müller, Miryam
name: Schumacher, Neele
name: Fritsch, Jürgen
name: Wichert, Rielana
name: Galun, Eithan
name: Bergmann, Juri
name: Röder, Christian
name: Schafmayer, Clemens
name: Egberts, Jan-Hendrik
name: Becker-Pauly, Christoph
name: Saftig, Paul
name: Lucius, Ralph
name: Schneider-Brachert, Wulf
name: Barikbin, Roja
name: Adam, Dieter
name: Voss, Matthias
name: Hitzl, Wolfgang
name: Krüger, Achim
name: Strilic, Boris
name: Sagi, Irit
name: Walczak, Henning
name: Rose-John, Stefan
name: Schmidt-Arras, Dirk
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: Innate immunity and inflammation, Solid tumors, Tumor immunology
subject: 610 Medizin

description: Metastasis is the major cause of death in cancer patients. Circulating tumor cells need to migrate through the endothelial layer of blood vessels to escape the hostile circulation and establish metastases at distant organ sites. Here, we identified the membrane-bound metalloprotease ADAM17 on endothelial cells as a key driver of metastasis. We show that TNFR1-dependent tumor cell–induced endothelial cell death, tumor cell extravasation, and subsequent metastatic seeding is dependent on the activity of endothelial ADAM17. Moreover, we reveal that ADAM17-mediated TNFR1 ectodomain shedding and subsequent processing by the γ-secretase complex is required for the induction of TNF-induced necroptosis. Consequently, genetic ablation of ADAM17 in endothelial cells as well as short-term pharmacological inhibition of ADAM17 prevents long-term metastases formation in the lung. Thus, our data identified ADAM17 as a novel essential regulator of necroptosis and as a new promising target for antimetastatic and advanced-stage cancer therapies
Sustaining complex interventions in long-term care: a qualitative study of direct care staff and managers
Creators: name: Song, Yuting
name: Anderson, Ruth
name: Batchelor-Murphy, Melissa
name: Burd, Andrew
name: Hall, Rasheeda
name: Anderson, Amber
name: Yap, Tracey
name: Cary, Michael P
name: Colón-Emeric, Cathleen
name: Toles, Mark
Publisher: name: BioMed Central
Year: 2016

description: Abstract Background Little is known about the sustainability of behavioral change interventions in long-term care (LTC). Following a cluster randomized trial of an intervention to improve staff communication (CONNECT), we conducted focus groups of direct care staff and managers to elicit their perceptions of factors that enhance or reduce sustainability in the LTC setting. The overall aim was to generate hypotheses about how to sustain complex interventions in LTC. Methods In eight facilities, we conducted 15 focus groups with 83 staff who had participated in at least one intervention session. Where possible, separate groups were conducted with direct care staff and managers. An interview guide probed for staff perceptions of intervention salience and sustainability. Framework analysis of coded transcripts was used to distill insights about sustainability related to intervention features, organizational context, and external supports. Results Staff described important factors for intervention sustainability that are particularly challenging in LTC. Because of the tremendous diversity in staff roles and education level, interventions should balance complexity and simplicity, use a variety of delivery methods and venues (e.g., group and individual sessions, role-play/storytelling), and be inclusive of many work positions. Intervention customizability and flexibility was particularly prized in this unpredictable and resource-strapped environment. Contextual features noted to be important include addressing the frequent lack of trust between direct care staff and managers and ensuring that direct care staff directly observe manager participation and support for the program. External supports suggested to be useful for sustainability include formalization of changes into facility routines, using “train the trainer” approaches and refresher sessions. High staff turnover is common in LTC, and providing materials for new staff orientation was reported to be important for sustainability. Conclusions When designing or implementing complex behavior change interventions in LTC, consideration of these particularly salient intervention features, contextual factors, and external supports identified by staff may enhance sustainability. Trial registration ClinicalTrial.gov, NCT00636675
title: Feeding arteries of primary tongue cancers on intra-arterial infusion chemotherapy
Creators: name: Kamitani, Takeshi
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Head and neck
subject: Interventional vascular
subject: Catheter arteriography
subject: Cone beam CT
subject: Arterial access
subject: Chemotherapy
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Intra-arterial infusion chemotherapy (IAIC) has the advantage of delivering a high concentration of drugs into the tumor [1]. Improvement of local control is expected, and this results in both functional and cosmetic preservation by preventing the...
Properties of Lithium-11 and Carbon-22 at leading order in halo effective field theory
Creators: name: Acharya, Bijaya
name: Phillips, Daniel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We study the $^{11}\mathrm{Li}$ and $^{22}\mathrm{C}$ nuclei at leading order (LO) in halo effective field theory (Halo EFT). Using the value of the $^{22}\mathrm{C}$ rms matter radius deduced in Ref. [1] as an input in a LO calculation, we simultaneously constrained the values of the two-neutron (2$n$) separation energy of $^{22}\mathrm{C}$ and the virtual-state energy of the $^{20}\mathrm{C}-$neutron system (hereafter denoted $^{21}$C). The 1$-σ$ uncertainty of the input rms matter radius datum, along with the theory error estimated from the anticipated size of the higher-order terms in the Halo EFT expansion, gave an upper bound of about 100 keV for the 2$n$ separation energy. We also study the electric dipole excitation of 2$n$ halo nuclei to a continuum state of two neutrons and the core at LO in Halo EFT. We first compare our results with the $^{11}\mathrm{Li}$ data from a Coulomb dissociation experiment and obtain good agreement within the theoretical uncertainty of a LO calculation. We then obtain the low-energy spectrum of $B(E1)$ of this transition at several different values of the 2$n$ separation energy of $^{22}\mathrm{C}$ and the virtual-state energy of $^{21}\mathrm{C}$. Our predictions can be compared to the outcome of an ongoing experiment on the Coulomb dissociation of $^{22}\mathrm{C}$ to obtain tighter constraints on the two- and three-body energies in the $^{22}\mathrm{C}$ system.
description: 6 pages, 3 figures; Contribution to the 21st International Conference on Few-Body Problems in Physics
Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal
Creators: name: Abel, Kristina
Publisher: name: BioMed Central Ltd
Year: 2012

description: Abstract Background: We reported previously that while prolonged tenofovir monotherapy of macaques infected with virulent simian immunodeficiency virus (SIV) resulted invariably in the emergence of viral mutants with reduced in vitro drug susceptibility and a K65R mutation in reverse transcriptase, some animals controlled virus replication for years. Transient CD8+ cell depletion or short-term tenofovir interruption within 1 to 5 years of treatment demonstrated that a combination of CD8+ cell-mediated immune responses and continued tenofovir therapy was required for sustained suppression of viremia. We report here follow-up data on 5 such animals that received tenofovir for 8 to 14 years. Results: Although one animal had a gradual increase in viremia from 3 years onwards, the other 4 tenofovir-treated animals maintained undetectable viremia with occasional viral blips (≤ 300 RNA copies/ml plasma). When tenofovir was withdrawn after 8 to 10 years from three animals with undetectable viremia, the pattern of occasional episodes of low viremia (≤ 3600 RNA/ml plasma) continued throughout the 10-month follow-up period. These animals had low virus levels in lymphoid tissues, and evidence of multiple SIV-specific immune responses. Conclusion: Under certain conditions (i.e., prolonged antiviral therapy initiated early after infection; viral mutants with reduced drug susceptibility) a virus-host balance characterized by strong immunologic control of virus replication can be achieved. Although further research is needed to translate these findings into clinical applications, these observations provide hope for a functional cure of HIV infection via immunotherapeutic strategies that boost antiviral immunity and reduce the need for continuous antiretroviral therapy.
Interactive Framework to Support OpenModel-Data Validation Efforts at the CCMC
Creators: name: Rastaetter, Lutz
name: Mullinix, Richard
name: Wang, Jack
name: De Zeeuw, Darren
name: Yihua Zheng
name: Kuznetsova, Maria
name: Yue, Jia
name: Mays, Leila
Publisher: name: Zenodo
Year: 2023
Subjects: Data Portals
Interactive Visualization
Open Source Software
Numerical Modeling
Data-Model Comparisons

description: Validation of models using observation data has been a central activity at the Community Coordinated Modeling Center (CCMC) over more than a decade. The Comprehensive Assessment of Models and Events using Library Tools (CAMEL) framework is a database-driven implementation of the interactive analysis of model-data comparisons that simultaneously provides a view across a multitude of locations and time periods. CAMEL thus extends the single-location or single-trajectory timeseries data comparison capabilities provided by the CCMC online visualization that formed the backbone of initial validation efforts. We demonstrate CAMEL capabilities using data-model comparison of Neutral density in the upper atmosphere which is one application among several data-model comparison studies in the Heliosphere, the Earth’s radiation belt, magnetosphere, and ionosphere-thermosphere-mesosphere domains.
Real-space renormalized dynamical mean field theory
Creators: name: Kubota, Dai
name: Sakai, Shiro
name: Imada, Masatoshi
Publisher: name: arXiv
Year: 2016
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We propose real-space renormalized dynamical mean field theory (rr-DMFT) to deal with large clusters in the framework of a cluster extension of the DMFT. In the rr-DMFT, large clusters are decomposed into multiple smaller clusters through a real-space renormalization. In this work, the renormalization effect is taken into account only at the lowest order with respect to the intercluster coupling, which nonetheless reproduces exactly both the noninteracting and atomic limits. Our method allows us large cluster-size calculations which are intractable with the conventional cluster extensions of the DMFT with impurity solvers, such as the continuous-time quantum Monte Carlo and exact diagonalization methods. We benchmark the rr-DMFT for the two-dimensional Hubbard model on a square lattice at and away from half filling, where the spatial correlations play important roles. Our results on the spin structure factor indicate that the growth of the antiferromagnetic spin correlation is taken into account beyond the decomposed cluster size. We also show that the self-energy obtained from the large-cluster solver is reproduced by our method better than the solution obtained directly for the smaller cluster. When applied to the Mott metal-insulator transition, the rr-DMFT is able to reproduce the reduced critical value for the Coulomb interaction comparable to the large cluster result.
description: 12 pages, 13 figures
Risk factors for maternal death and trends in maternal mortality in low- and middle-income countries: a prospective longitudinal cohort analysis
Creators: name: Bose, Carl
name: Bauserman, Melissa
Publisher: name: BioMed Central
Year: 2015

description: Abstract Background Because large, prospective, population-based data sets describing maternal outcomes are typically not available in low- and middle-income countries, it is difficult to monitor maternal mortality rates over time and to identify factors associated with maternal mortality. Early identification of risk factors is essential to develop comprehensive intervention strategies preventing pregnancy-related complications. Our objective was to describe maternal mortality rates in a large, multi-country dataset and to determine maternal, pregnancy-related, delivery and postpartum characteristics that are associated with maternal mortality. Methods We collected data describing all pregnancies from 2010 to 2013 among women enrolled in the multi-national Global Network for Women’s and Children’s Health Research Maternal and Neonatal Health Registry (MNHR). We reported the proportion of mothers who died per pregnancy and the maternal mortality ratio (MMR). Generalized linear models were used to evaluate the relationship of potential medical and social factors and maternal mortality and to develop point and interval estimates of relative risk associated with these factors. Generalized estimating equations were used to account for the correlation of outcomes within cluster to develop appropriate confidence intervals. Results We recorded 277,736 pregnancies and 402 maternal deaths for an MMR of 153/100,000 live births. We observed an improvement in the total MMR from 166 in 2010 to 126 in 2013. The MMR in Latin American sites (91) was lower than the MMR in Asian (178) and African sites (125). When adjusted for study site and the other variables, no formal education (RR 3.2 [1.5, 6.9]), primary education only (RR 3.4 [1.6, 7.5]), secondary education only (RR 2.5 [1.1, 5.7]), lack of antenatal care (RR 1.8 [1.2, 2.5]), caesarean section delivery (RR 1.9 [1.3, 2.8]), hemorrhage (RR 3.3 [2.2, 5.1]), and hypertensive disorders (RR 7.4 [5.2, 10.4]) were associated with higher risks of death. Conclusions The MNHR identified preventable causes of maternal mortality in diverse settings in low- and middle-income countries. The MNHR can be used to monitor public health strategies and determine their association with reducing maternal mortality. Trial Registration clinicaltrials.gov NCT01073475
Coherent ultrafast spin-dynamics probed in three dimensional topological insulators
Creators: name: Boschini, F.
name: Mansurova, M.
name: Mussler, G.
name: Kampmeier, J.
name: Grützmacher, D.
name: Braun, L.
name: Katmis, F.
name: Moodera, J. S.
name: Dallera, C.
name: Carpene, E.
name: Franz, C.
name: Czerner, M.
name: Heiliger, C.
name: Kampfrath, T.
name: Münzenberg, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Topological insulators are candidates to open up a novel route in spin based electronics. Different to traditional ferromagnetic materials, where the carrier spin-polarization and magnetization are based on the exchange interaction, the spin properties in topological insulators are based on the coupling of spin- and orbit interaction connected to its momentum. Specific ways to control the spin-polarization with light have been demonstrated: the energy momentum landscape of the Dirac cone provides spin-momentum locking of the charge current and its spin. The directionality of spin and momentum, as well as control with light has been demonstrated. Here we demonstrate a coherent femtosecond control of spin-polarization for states in the valence band at around the Dirac cone.
description: 14 pages, 4 figures
title: Interventional management of postoperative ureteric complications after pelvic surgery
Creators: name: Tabashy, Reda
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Interventional non-vascular
subject: Urinary Tract / Bladder
subject: Fluoroscopy
subject: Technical aspects

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Urinary leakage occurs in 4% of patients after urinary diversion. The most frequent site of leakage is the ureteral- reservoir anastomosis [1]. Ureteral stricture occurs more commonly at the Ureteroenteric anastomosis with frequency of 1% to 30%...
Semiparametric methods for genome-wide linkage analysis of human gene expression data
Creators: name: Lin, Danyu
Publisher: name: BioMed Central Ltd
Year: 2007

description: Abstract With the availability of high-throughput microarray technologies, investigators can simultaneously measure the expression levels of many thousands of genes in a short period. Although there are rich statistical methods for analyzing microarray data in the literature, limited work has been done in mapping expression quantitative trait loci (eQTL) that influence the variation in levels of gene expression. Most existing eQTL mapping methods assume that the expression phenotypes follow a normal distribution and violation of the normality assumption may lead to inflated type I error and reduced power. QTL analysis of expression data involves the mapping of many expression phenotypes at thousands or hundreds of thousands of marker loci across the whole genome. An appropriate procedure to adjust for multiple testing is essential for guarding against an abundance of false positive results. In this study, we applied a semiparametric quantitative trait loci (SQTL) mapping method to human gene expression data. The SQTL mapping method is rank-based and therefore robust to non-normality and outliers. Furthermore, we apply an efficient Monte Carlo procedure to account for multiple testing and assess the genome-wide significance level. Particularly, we apply the SQTL mapping method and the Monte-Carlo approach to the gene expression data provided by Genetic Analysis Workshop 15.
title: Petrosquamosal Sinus without Associated Skull Base Anomalies on CT
Creators: name: Abe, Shoko
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Congenital
subject: Computer Applications-Detection, diagnosis
subject: CT-High Resolution
subject: CT
subject: Head and neck
subject: Ear / Nose / Throat
subject: Anatomy

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The petrosquamosal sinus (PSS) is an embryological emissary vein located along the petrosquamosal fissure that connects the intra- and extracranial venous networks (1). The PSS has been considered to usually regress during development (2), while it...
title: Multimodality imaging of upper and lower extremity injuries in triathlon - a pictorial review
Creators: name: Guermazi, Ali
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Extremities
subject: Musculoskeletal soft tissue
subject: Musculoskeletal joint
subject: MR
subject: Ultrasound
subject: CT
subject: Diagnostic procedure
subject: Athletic injuries
subject: Occupational / Environmental hazards

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: 1. To describe epidemiology of triathlon injuries 2. To illustrate types and mechanisms of triatlon injuries of the upper and lower extremities 3. To review importance of multimodality imaging in clinical...
Common carotid artery wall thickness and external diameter as predictors of prevalent and incident cardiac events in a large population study
Creators: name: Couper, David
name: Rose, Kathryn M.
Publisher: name: BioMed Central Ltd
Year: 2007

description: Abstract Background Arterial diameters enlarge in response to wall thickening, plaques, and many atherosclerotic risk factors. We hypothesized that right common carotid artery (RCCA) diameter would be independently associated with cardiac disease and improve risk discrimination. Methods In a middle-aged, biracial population (baseline n = 11225), we examined associations between 1 standard deviation increments of baseline RCCA diameter with prevalent myocardial infarction (MI) and incident cardiac events (MI or cardiac death) using logistic regression and Cox proportional hazards models, respectively. Areas under the receiver operator characteristic curve (AUC) were used to estimate model discrimination. Results MI was present in 451 (4%) participants at baseline (1987–89), and incident cardiac events occurred among 646 (6%) others through 1999. Adjusting for IMT, RCCA diameter was associated with prevalent MI (female OR = 2.0, 95%CI = 1.61–2.49; male OR = 1.16, 95% CI = 1.04–1.30) and incident cardiac events (female HR = 1.75, 95% CI = 1.51–2.02; male HR = 1.27, 95% CI = 1.15–1.40). Associations were attenuated but persisted after adjustment for risk factors (not including IMT) (prevalent MI: female OR = 1.73, 95% CI = 1.40–2.14; male OR = 1.14, 95% CI = 1.02–1.28, and incident cardiac events: female HR = 1.26, 95% CI = 1.08–1.48; male HR = 1.19, 95% CI = 1.08–1.32). After additional adjustment for IMT, diameter was associated with incident cardiac events in women (HR = 1.18, 95% CI = 1.00–1.40) and men (HR = 1.17, 95% CI = 1.06–1.29), and with prevalent MI only in women (OR = 1.73; 95% CI = 1.37–2.17). In women, when adjustment was limited, diameter models had larger AUC than other models. Conclusion RCCA diameter is an important correlate of cardiac events, independent of IMT, but adds little to overall risk discrimination after risk factor adjustment.