cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Dynamics of the personalities of PCSK9 on missense variants (rs505151 and rs562556) from elderly cohort studies in Brazil
Creators: name: Lopes, Vitor Galvão
name: de Oliveira, Victor Fernandes
name: Dati, Livia Mendonça Munhoz
name: Naslavsky, Michel Satya
name: Ferreira, Glaucio Monteiro
name: Hirata, Mario Hiroyuki
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: The Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) promotes the degradation of the low-density lipoprotein receptors (LDLR). Gain-of-function (GOF) variants of PCSK9 significantly affects lipid metabolism leading to coronary artery disease (CAD), owing to the raising the plasma low-density lipoprotein (LDL). Considering the public health matter, large-scale genomic studies have been conducted worldwide to provide the genetic architecture of populations for the implementation of precision medicine actions. Nevertheless, despite the advances in genomic studies, non-European populations are still underrepresented in public genomic data banks. Despite this, we found two high-frequency variants (rs505151 and rs562556) in the ABraOM databank (Brazilian genomic variants) from a cohort SABE study conducted in the largest city of Brazil, São Paulo. Here, we assessed the structural and dynamical features of these variants against WT through a molecular dynamics study. We sought fundamental dynamical interdomain relations through Perturb Response Scanning (PRS) and we found an interesting change of dynamical relation between prodomain and Cysteine-Histidine-Rich-Domain (CHRD) in the variants. The results highlight the pivotal role of prodomain in the PCSK9 dynamic and the implications for the development of new drugs depending on patient group genotype.
Hecke-Clifford Algebras and Spin Hecke Algebras IV: Odd Double Affine Type
Creators: name: Khongsap, Ta
name: Wang, Weiqiang
Publisher: name: arXiv
Year: 2008
Subjects: subject: Representation Theory (math.RT)
subject: Quantum Algebra (math.QA)
subject: FOS: Mathematics

description: We introduce an odd double affine Hecke algebra (DaHa) generated by a classical Weyl group W and two skew-polynomial subalgebras of anticommuting generators. This algebra is shown to be Morita equivalent to another new DaHa which are generated by W and two polynomial-Clifford subalgebras. There is yet a third algebra containing a spin Weyl group algebra which is Morita (super)equivalent to the above two algebras. We establish the PBW properties and construct Verma-type representations via Dunkl operators for these algebras.
Validation of a sailing simulator using full scale experimental data
Creators: name: Clark, NA
Publisher: name: University Of Tasmania
Year: 2023

description: Virtual Sailing Pty Ltd is an Australian company that for over 10 years has invested significant time and resources into developing a ride on sailing simulator, which replicates several classes including the Laser and megabyte sailing dinghies. The simulator provides a means for training and performance assessment of sailors; including the feature of providing rehabilitation and training for disabled body sailors through the V-Sail Access Simulator. Prior to this project, the sailing simulator had not been validated with experimental testing. It was proposed that an experimental Data Acquisition System be used in a series of manoeuvring trials, in order to obtain experimental validation data. Full scale experimental testing was performed at Albert Park Lake, Melbourne. The aim of testing was to acquire validation data including dinghy velocity over land; Apparent Wind Speed (AWS) and Apparent Wind Angle (AWA), Rudder angle and GPS position. Subsequent testing on the simulator using experimental course data from Albert Park Lake was used to systematically repeat full scale course laps and manoeuvres in order to obtain simulated data for comparison with experimental data. Comparison between experimental and simulated data formed the validation component of the project. The validation study found that the manoeuvring model employed in the simulator replicated the results from experimental testing, especially with regard to manoeuvring response of the simulator compared to experimental results. Average dinghy velocity through specific headings relative to true wind angle showed variation to the simulator (within an order of magnitude), which requires further investigation. Specifically, it is recommended that future work investigates the validation of the main resistance and powering components of the simulation, including but not limited to; hydrodynamic hull drag, righting moment provided/required by the sailor, and aerodynamic sail forces. Finally, the Data Acquisition System and supporting equipment was found to be robust, and potentially applicable to other marine vessels.
Dynamics of a three-dimensional inextensible chain
Creators: name: Ferrari, Franco
name: Paturej, Jaroslaw
name: Vilgis, Thomas A.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: In the first part of this work the classical and statistical aspects of the dynamics of an inextensible chain in three dimensions are investigated. In the second part the special case of a chain admitting only fixed angles with respect to the $z-$axis is studied using a path integral approach. It is shown that it is possible to reduce this problem to a two-dimensional case, in a way which is similar to the reduction of the statistical mechanics of a directed polymer to the random walk of a two-dimensional particle.
description: 15 pages, 3 figures, LaTeX, version accepted for publication
Scicli: onomastica e toponomastica - Introduzione
Creators: name: Micciché, Salvo
Publisher: name: Zenodo
Year: 2017
Subjects: Scicli
storia
onomastica
toponomastica

description: L'introduzione del volume "Scicli: onomastica e toponomastica" di Salvo Micciché (Il Giornale di Scicli - Biancavela), 2017. Sinossi: A 26 anni di distanza da Onomastica di Scicli (Il Giornale di Scicli, 1991), Salvo Micciché propone un nuovo studio sull’etimologia e la storia dei cognomi e dei luoghi di Scicli (Xicli) che comprende le 550 voci onomastiche del precedente libro (ora sono 1100 i cognomi trattati) e aggiunge oltre 200 toponimi, con note storiche, archeologiche, araldiche, etimologiche e semantiche. Un apparato testuale di 600 note, una bibliografia ampliata e un indice analitico aiutano il Lettore a portare avanti la ricerca. Un prezioso Stemmario con 138 armi araldiche di Scicli impreziosisce l’opera (altri 150 blasoni sono descritti nel testo). Nel libro sono inseriti contributi di Stefania Fornaro, Ignazio La China, Elio Militello, Pietro Militello, Paolo Militello, Giuseppe Nativo, Paolo Nifosì, Giuseppe Pitrolo.
Discrete Minimal Flavour Violation
Creators: name: Zwicky, R.
name: Fischbacher, T.
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We investigate the consequences of replacing the continuous flavour symmetry of minimal flavour violation by a discrete group. Goldstone bosons, resulting from the breaking of the continuous flavour symmetry, generically lead to bounds on new flavour structure by many orders of magnitude above the TeV-scale. The absence of Goldstone bosons for discrete symmetries constitutes the primary motivation of our work. The four crystal-like groups Sigma(168), Sigma(72phi), Sigma(216phi) and Sigma(360phi)$ provide enough protection for a discrete TeV-scale MFV scenario in the case where Delta F = 2 processes are generated by two subsequent Delta F = 1 transitions.
description: Presented at Flavianet workshop on "Low energy constraints on extensions of the Standard Model" from 23-27 July 2009 in Kazimierz, Poland and "Progress and Challenges in Flavour Physics" 29 Sep- 3 Oct 2009 in Primosten, Croatia, 7 pages, 1 figure
The Effect of Lunar-like Satellites on the Orbital Infrared Light Curves of Earth-analog Planets
Creators: name: Moskovitz, Nicholas A.
name: Gaidos, Eric
name: Williams, Darren
Publisher: name: arXiv
Year: 2008
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We investigate the influence of lunar-like satellites on the infrared orbital light curves of Earth-analog extra-solar planets. Such light curves will be obtained by NASA's Terrestrial Planet Finder (TPF) and ESA's Darwin missions as a consequence of repeat observations to confirm the companion status of a putative planet. We use an energy balance model to calculate disk-averaged infrared (bolometric) fluxes from planet-satellite systems over a full orbital period (one year). The satellites are assumed to lack an atmosphere, have a low thermal inertia like that of the Moon and span a range of plausible radii. The planets are assumed to have thermal and orbital properties that mimic those of the Earth while their obliquities and orbital longitudes of inferior conjunction remain free parameters. Even if the gross thermal properties of the planet can be independently constrained (e.g. via spectroscopy or visible-wavelength detection of specular glint from a surface ocean) only the largest (approximately Mars-size) lunar-like satellites can be detected by light curve data from a TPF-like instrument (i.e. one that achieves a photometric signal-to-noise of 10-20 at infrared wavelengths). Non-detection of a lunar-like satellite can obfuscate the interpretation of a given system's infrared light curve so that it may resemble a single planet with high obliquity, different orbital longitude of vernal equinox relative to inferior conjunction and in some cases drastically different thermal characteristics. If the thermal properties of the planet are not independently established then the presence of a lunar-like satellite cannot be inferred from infrared data, thus demonstrating that photometric light curves alone can only be used for preliminary study of extra-solar Earth-like planets.
description: 34 pages, 7 figures, accepted to Astrobiology
A novel class of phenylpyrazolone-sulphonamides rigid synthetic anticancer molecules selectively inhibit the isoform IX of carbonic anhydrases guided by molecular docking and orbital analyses
Creators: name: Khayat, Maan T.
name: Ahmed, Hany E. A.
name: Omar, Abdelsattar M.
name: Muhammad, Yosra A.
name: Mohammad, Khadijah A.
name: Malebari, Azizah M.
name: Khayyat, Ahdab N.
name: Halawa, Ahmed H.
name: Abulkhair, Hamada S.
name: Al-Karmalawy, Ahmed A.
name: Almaghrabi, Mohammed
name: Alharbi, Majed
name: Aljahdali, Anfal S.
name: El-Agrody, Ahmed M.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: All the previously reported phenylpyrazoles as carbonic anhydrase inhibitors (CAIs) were found to have small sizes and high levels of flexibility, and hence showed low selectivity profiles toward a particular isoform of CA. Herein, we report the development of a more rigid ring system bearing a sulfonamide hydrophilic head and a lipophilic tail to develop novel molecules that are suggested to have a better selectivity toward a special CA isoform. Accordingly, three novel sets of pyrano[2,3-c]pyrazoles attached with sulfonamide head and aryl hydrophobic tail were synthesized to enhance the selectivity toward a specific isoform of human carbonic anhydrases (hCAs). The impact of both attachments on the potency and selectivity has been extensively discussed in terms of in vitro cytotoxicity evaluation under hypoxic conditions, structure–activity relationship and carbonic anhydrase enzyme assay. All of the new candidates displayed good cytotoxic activities against breast and colorectal carcinomas. Results of the carbonic anhydrase enzyme assay demonstrated the preferential of compounds 22, 24 and 27 to inhibit the isoform IX of hCAs selectively. Wound-healing assay has also been performed and revealed the potential of 27 to decrease the wound closure percentage in MCF-7 cells. Molecular docking and molecular orbital analysis have finally been conducted. Results indicate the potential binding interactions of 24 and 27 with several crucial amino acids of the hCA IX. Communicated by Ramaswamy H. Sarma
MOESM9 of Transcriptome analysis of Clinopodium gracile (Benth.) Matsum and identification of genes related to Triterpenoid Saponin biosynthesis
Creators: name: Shan, Chunmiao
name: Wang, Chenkai
name: Zhang, Shengxiang
name: Shi, Yuanyuan
name: Ma, Kelong
name: Yang, Qingshan
name: Wu, Jiawen
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 9: Figure S5. Photograph of C. gracile plants. The picture was photographed for the plants of C. gracile in the herbal garden of the Anhui University of Chinese Medicine on April 18, 2018.
Superconducting Fe(1+delta)Se(1-x)Te(x) thin films: Growth, characterization and properties
Creators: name: Kumary, T. Geetha
name: Baisnab, Dipak Kumar
name: Janaki, J.
name: Mani, Awadhesh
name: Sarguna, R. M.
name: Ajikumar, P. K.
name: Tyagi, A. K.
name: Bharathi, A.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Thin films of Fe(1+delta)Se(1-x)Te(x) (delta ~ 0.18 & x ~ 0.5) have been successfully grown on (100) oriented single crystalline SrTiO3 and LaAlO3 substrates by pulsed laser deposition. The crystal structure was characterized by x-ray diffraction, and the superconducting properties by electrical resistivity measurements. X-ray diffraction analysis establishes the epitaxial growth of the films with c-axis orientation. Atomic force microscopy showed a smooth surface morphology for the films grown on SrTiO3 substrates. All the films are observed to be superconducting with a Tc of ~ 8-14 K depending on the deposition conditions. The deposition parameters were optimized to obtain good quality films with Tc comparable to that of the target material.
Structure of the Galaxies in the NGC 80 Group
Creators: name: Startseva, Marina A.
name: Sil'chenko, Olga K.
name: Moiseev, Alexei V.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: BV-bands photometric data obtained at the 6-m telescope of the Special Astrophysical Observatory are used to analyze the structure of 13 large disk galaxies in the NGC 80 group. Nine of the 13 galaxies under consideration are classified by us as lenticular galaxies. The stellar populations in the galaxies are very different, from old ones with ages of T>10 Gyrs (IC 1541) to relatively young, with the ages of T<2-3 Gyr (IC 1548, NGC 85). In one case, current star formation is known (UCM 0018+2216). In most of the galaxies, more precisely in all of them more luminous than M(B) -18, two-tiered (`antitruncated') stellar disks are detected, whose radial surface brightness profiles can be fitted by two exponential segments with different scalelengths -- shorter near the center and longer at the periphery. All dwarf S0 galaxies with single-scalelength exponential disks are close companions to giant galaxies. Except for this fact, no dependence of the properties of S0 galaxies on distance from the center of the group is found. Morphological traces of minor merger are found in the lenticular galaxy NGC 85. Basing on the last two points, we conclude that the most probable mechanisms for the transformation of spirals into lenticular galaxies in groups are gravitational ones, namely, minor mergers and tidal interactions.
description: 24 pages, 9 figures, slightly improved version of the paper published in the December, 2009, issue of the Astronomy Reports
Interruptions to school-based childhood immunization programs & policies as a result of COVID-19: A Scoping Review
Creators: name: Gallant, Allyson
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: Social and Behavioral Sciences

description: A scoping review to identify and describe the literature surrounding how routine school-based immunization programs were affected during the COVID-19 pandemic.
Poetic "play" and man's dilemmas: studies in the poetry of Donne and Marvell
Creators: name: Watson, Christopher John
Publisher: name: University of British Columbia
Year: 2011

description: Donne and Marvell are renowned as 'witty' poets. The description is invited by such habits as the use of extravagant imagery, the arguing of implausible positions, the striking of threatrical poses which call in question their attitude to themselves and to their stated views. These qualities appear not only in their slight poems, but in works that are demonstrably major, in poems which, are weighty, perceptive, and passionately committed. The aim of this study is to examine a number of their major poems in some detail to see how integral their playful qualities are in establishing their full meaning. A number of Marvell's shorter poems, "A Dialogue between the Soul and Body", the four "Mower" poems, and "To his Coy Mistress" look at fundamental human dilemmas. Artfully constructed situations and witty discussions provide parables for representative human problems, especially ones concerning the difficulties of growth and of action within a finite and mutable world.
Dynamo-generated magnetic fields in fast rotating single giants
Creators: name: Konstantinova-Antova, Renada
name: Aurière, Michel
name: Schröder, Klaus-Peter
name: Petit, Pascal
Publisher: name: arXiv
Year: 2009
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Red giants offer a good opportunity to study the interplay of magnetic fields and stellar evolution. Using the spectro-polarimeter NARVAL of the Telescope Bernard Lyot (TBL), Pic du Midi, France and the LSD technique, we began a survey of magnetic fields in single G-K-M giants. Early results include 6 MF-detections with fast rotating giants, and for the first time a magnetic field was detected directly in an evolved M-giant: EK Boo. Our results could be explained in the terms of $α$--$ω$ dynamo operating in these giants.
description: 2 pages, 1 figure, proceedings of IAUS259: Cosmic Magnetic Fields
Delineating the impact of pathogenic mutations on the conformational dynamics of HDL’s vital protein ApoA1: a combined computational and molecular dynamic simulation approach
Creators: name: Bhale, Aishwarya Sudam
name: Venkataraman, Krishnan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Computational Biology

description: Apolipoprotein A1 (ApoA1), is the important component of high‐density lipoproteins (HDL), that has key role in HDL biogenesis, cholesterol trafficking, and reverse cholesterol transport (RCT). Non-synonymous Single Nucleotide Polymorphisms (nsSNPs) in ApoA1 have been linked to cardiovascular diseases and amyloidosis as they alter the protein’s native structure and function. Therefore in this study, we attempted to understand the molecular pathogenicity profile of nsSNPs of ApoA1 using various computational approaches. We used state-of-the-art computational methods to thoroughly investigate the 295 ApoA1 nsSNPs at sequence and structural levels. Seven nsSNPs (L13R, L84R, L84P, L99P, R173P, L187P, and L238P) out of 295 were classified as the most deleterious and destabilizing. In order to estimate the effect of such destabilizing mutations on the protein conformation, all-atom molecular dynamics simulations (MDS) of ApoA1 wild-type (WT), L99P and R173P for 100 ns, was carried out using GROMACS 5.0.1 package. The MD simulation investigation revealed significant structural alterations in L99P and R173P. In addition, they had changed principal component analysis and electrostatic surface potential, decreased structural compactness, and intramolecular hydrogen bonds, which supported the rationale underpinning ApoA1 dysfunction with such mutations. This work sheds light on ApoA1 dysfunction due to single amino acid alterations, and offers new insight into the molecular basis of ApoA1-related diseases progression. Communicated by Ramaswamy H. Sarma ApoA1 is a key HDL protein involved in RCT and HDL synthesis. Mutations in the ApoA1 protein can lead to defects in RCT and HDL biogenesis. In total 295nsSNPS of ApoA1 protein were studied using various computational approaches. Seven highly pathogenic and destabilizing mutations were found (L13R, L84R, L84P, L99P, R173P, L187P, and L238P). Further MD results showed L99P and R173P mutations in ApoA1 are highly destabilizing.
Poster "Reducing exposure to Endocrine-Disrupting Chemicals in pregnant and lactating women: The HYPIEND perinatal Randomized Controlled Trial"
Creators: name: Moulin, Cedric
name: Bogaerts, Annick
name: Miserez, Leonie
name: Freire, Carmen
name: Velasco, Inés
name: Ocaña, Marta
name: Baska, Alicja
name: Ciebiera, Michal
name: Dievlieger, Roland
Publisher: name: Zenodo
Year: 2024

description: Increasing evidence highlights the impact of exposure to mixtures of endocrine-disrupting chemicals (EDCs) in humans. Found in nutrition, cosmetics, and the environment, EDCs can disrupt the endocrine system governed by the hypothalamus-pituitary (HP) axis. This is especially concerning during critical developmental stages like the perinatal period, as data suggest high EDC exposure can harm infant growth and neurodevelopment, and may contribute to the rise of obesity and diabetes (1–3). To date, few intervention studies have assessed whether reducing perinatal EDC exposure can mitigate these harmful effects, and they have entailed considerable limitations. In response, HYPIEND aims to evaluate a multicomponent intervention to reduce perinatal EDC exposure.

This HYPIEND poster was presented at the 6th European Conference on Preconception Health and Care, organised by KU Leuven, REALIFE research group and Vives department Healthcare.
description: The HYPIEND project has received funding from the Horizon Europe programme under grant agreement No. 101137440. Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the Health and Digital Executive Agency. Neither the European Union nor the granting authority can be held responsible for them.
Influence of external electric fields on multi-photon transitions between the 2s, 2p and 1s levels for hydrogen and anti-hydrogen atoms and hydrogen-like ions
Creators: name: Solovyev, D.
name: Labzowsky, L.
name: Plunien, G.
name: Sharipov, V.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: One- and two-photon transitions in the hydrogen atom are analytically evaluated in the absence and in the presence of an external electric field. The emission probabilities are different for the hydrogen and anti-hydrogen atoms due to the existence of contributions, linear in electric field. The magnitude of these contributions is evaluated within the nonrelativistic limit. The Coulomb Green function method is applied. Different nonrelativistic "forms" for the decay probabilities in combination with different gauge choices are considered. The three-photon E1E1E1 2p-1s transition probability is also evaluated and possible applications of the results are discussed.
description: 23 pages, 1 table
Анализ приоритетов развития советской экономики в послевоенный период реконверсии
Creators: name: Таштанова Гюлар Фирдовси кызы
Publisher: name: Zenodo
Year: 2025
Subjects: тяжелая промышленность
производительность труда
реконверсия экономики
социальное обеспечение
материальное и моральное стимулирование
heavy industry
labor productivity
economic reconversion
social conditions
material and moral motivation

description: Аннотация. В статье изучены приоритеты, которые были обозначены советским руководством как ключевые, в процессе послевоенной реконверсии советской экономики и ее восстановления. Выделены перекосы экономического развития. Восстановление и развитие тяжелой промышленности определено как доминирующее перед созданием нормальных условий жизни населения. Оценены полученные итоги советского послевоенного экономического развития. Сделан вывод, что мотивационные факторы, продемонстрировавшие положительный эффект в годы первой послевоенной пятилетки, могут быть использованы при планировании развития отечественной экономики в условиях санкционной изоляции, стимулирующей ее коренную перестройку при активном импортозамещении. 

Abstract. The article examines the priorities that were designated by the Soviet leadership as key ones in the process of post-war reconversion of the Soviet economy and its restoration. The distortions of economic development are highlighted. The restoration and development of heavy industry is defined as dominant over the creation of normal living conditions for the population. The obtained results of the Soviet post-war economic development are assessed. It is concluded that the motivational factors that demonstrated a positive effect during the first post-war five-year plan can be used in planning the development of the domestic economy in the conditions of sanction isolation, stimulating its radical restructuring with active import substitution.
A novel site-controlled quantum dot system with high uniformity and narrow excitonic emission
Creators: name: Mereni, L. O.
name: Dimastrodonato, V.
name: Young, R. J.
name: Pelucchi, E.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We report on the optical properties of a newly developed site-controlled InGaAs Dots in GaAs barriers grown in pre-patterned pyramidal recesses by metalorganic vapour phase epitaxy. The inhomogeneous broadening of excitonic emission from an ensemble of quantum dots is found to be extremely narrow, with a standard deviation of 1.19 meV. A dramatic improvement in the spectral purity of emission lines from individual dots is also reported (18-30 ueV) when compared to the state-of-the-art for site controlled quantum dots.
description: PLMCN9 conference proceedings
Comparative anti-Diabetic potential of phytocompounds from Dr. Duke's phytochemical and ethnobotanical database and standard antidiabetic drugs against diabetes hyperglycemic target proteins: an in silico validation
Creators: name: Jayabal, D.
name: Jayanthi, S.
name: Thirumalaisamy, R.
name: Karthika, R.
name: Iqbal, Muhammad Nasir
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: In the current investigation, the antidiabetic potential of 40 phytocompounds from Dr. Dukes phytochemical and ethanobotanical database and three antidiabetic pharmaceuticals from the market comparatively validated against hyperglycemic target proteins. Silymarin, proanthocyanidins, merremoside, rutin, mangiferin-7-O-beta-glucoside, and gymnemic acid exhibited good binding affinity toward protein targets of diabetes among the 40 phytocompounds from Dr.Dukes database over three chosen antidiabetic pharmaceutical compounds. Further these phytocompounds and sitagliptin are validated for its ADMET and bioactivity score to screen its pharmacological and pharmacokinetics properties. Silymarin, proanthocyanidins, rutin along with sitagliptin screened for DFT analysis found that phytocompounds have great Homo–Lumo orbital energies over commercial pharmaceutical sitagliptin. Finally, four complexes of alpha amylase-silymarin, alpha amylase-sitagliptin, aldose reductase-proanthocyanidins, and aldose reductase-sitagliptin screened for MD simulation and MMGBSA analysis, results shown that the phytocompounds silymarin and proanthocyanidins have strong affinities for binding to the binding pockets of alpha amylase and aldose reductase respectively over antidiabetic pharmaceuticals. Our current study proven proanthocyanidins and silymarin act as novel antidiabetic compounds toward diabetic target protein but it require clinical trial to evaluate its clinical pertinence toward diabetic target proteins. Communicated by Ramaswamy Sarma
Excitations of the bimodal Ising spin glass on the brickwork lattice
Creators: name: Atisattapong, W.
name: Poulter, J.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: An exact algorithm is used to investigate the distributions of the degeneracies of low-energy excited states for the bimodal Ising spin glass on the brickwork lattice. Since the distributions are extreme and do not self-average, we base our conclusions on the most likely values of the degeneracies. Our main result is that the degeneracy of the first excited state per ground state and per spin is finite in the thermodynamic limit. This is very different from the same model on a square lattice where a divergence proportional to the linear lattice size is expected. The energy gap for the brickwork lattice is obviously 2J on finite systems and predicted to be the same in the thermodynamic limit. Our results suggest that a 2J gap is universal for planar bimodal Ising spin glasses. The distribution of the second contribution to the internal energy has a mode close to zero and we predict that the low-temperature specific heat is dominated by the leading term proportional to $T^{-2} \exp(-2J/kT)$.
description: 7 pages, 13 figures
From the sublime to the meticulous : a reappraisal of the changing roles of women within the Quaker Movement in England through the establishment of separate women's meetings in the 1670s
Creators: name: Caney, Avril D
Publisher: name: University Of Tasmania
Year: 2023

description: Quakerism emerged as one of the radical sects of the English Civil War years. Following the 16th century Reformation, radical Protestants and mainstream Protestants all over Europe could be distinguished very largely by their contrasting attitude to the existing political systems and social structures in which they operated. Mainstream Protestant churches, such as Calvinists, Lutherans, Anglicans and Scottish Presbyterians came to terms with the institutions shaping society by entering into an official relationship with the State. The multifarious strands of radical Protestantism were united only in their general opposition to the State. Some, including Quakers, experienced a militant or activist phase during which they pressured governments with demands for reform or even attempted to precipitate revolution. Ultimately most of these sects became reconciled to considering themselves a godly remnant within an evil society, and concentrated on preserving internal purity.
Entanglement measurement of the quadrature components without the homodyne detection in the spatially multi-mode far-field
Creators: name: Golubeva, T.
name: Golubev, Yu.
name: Samburskaya, K.
name: Fabre, C.
name: Treps, N.
name: Kolobov, M.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We consider the measuring procedure that in principle allows to avoid the homodyne detection for the simultaneous selection of both quadrature components in the far-field. The scheme is based on the use of the coherent sources of the non-classical light. The possibilities of the procedure are illustrated on the basis of the use of pixellised sources, where the phase-locked sub-Poissonian lasers or the degenerate optical parametric oscillator generating above threshold are chosen as the pixels. The theory of the pixellised source of the spatio-temporal squeezed light is elaborated as a part of this investigation.
description: 11 pages, 5 figures, RevTeX4. Submitted to Phys. Rev. A
title: Blessed are those who weep: gratia lacrymarum in thirteenth-century hagiographies
Creators: name: Knight, Kimberley-Joy
Publisher: name: University of St Andrews
Year: 2014

description: Hagiographies and canonisation processes from the thirteenth century are
frequently saturated with descriptions of tears. The tears of holy men and women
were both the means to, and apex of, spiritual perfection. Using hagiographical
sources from the new Mendicant Orders emerging in Italy, France and the Low
Countries, but drawing on other important examples when appropriate, this thesis
demonstrates the complexity and importance of tears in thirteenth-century
religious life. It makes significant contributions to understanding the construction of sainthood and the history of emotions during this critical period. Case studies of the beguine Marie d’Oignies (d.1213), and the founder of the preaching friars Dominic of Caleruega (d.1221), developed in chapters one and two allow for the meaning of tears to be explored fully and contextualised within the broader
themes of devotional piety, gender, medicine and physiology, and the cult of
saints. The hypotheses raised in these case studies are tested in chapter three using
an extensive sample of vitae to demonstrate the importance of tears. In order to
navigate the sea of tears, the study offers a bipartite conceptual framework that
takes into account both a charismatic experience of tears (often known as gratia
lacrymarum) and a progressive, transformative journey through tears. Building on
Piroska Nagy’s seminal work Le Don des Larmes, this thesis presents a
comprehensive analysis of tears in thirteenth-century hagiographies. It argues that they were not devalued in light of other forms of bodily piety nor did they become mere virtues in light of their proliferation; on the contrary, tears were highly valued and saturated religious life, traversing boundaries of what was to be
imitated and admired.
MOESM11 of Comprehensive analysis of miRNA profiles reveals the role of Schistosoma japonicum miRNAs at different developmental stages
Creators: name: Yu, Jie
name: Yu, Ying
name: Li, Qing
name: Chen, Muxin
name: Shen, Haimo
name: Zhang, RuiXiang
name: Song, Mingxin
name: Hu, Wei
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Computational Biology

description: Additional file 11. Network of transferase activity and their targets in female and male. The relationship between transferase activity and their targets in female and male were processed in cytoscape3.6.0. Purple, square represented enrichments in female. Blue, square represented enrichments in male. Turquoise, oval represented miRNA targets.
Atomic Clocks and Coherent Population Trapping: Experiments for Undergraduate Laboratories
Creators: name: Belcher, Nathan
name: Mikhailov, Eugeniy E.
name: Novikova, Irina
Publisher: name: arXiv
Year: 2008
Subjects: subject: Physics Education (physics.ed-ph)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We demonstrate how to construct and operate a simple and affordable experimental apparatus, appropriate for an undergraduate setting, in order to produce and study coherent effects in atomic vapor and to investigate their applications for metrology. The apparatus consists of a vertical cavity surface emitting diode laser (VCSEL) directly current-modulated using a tunable microwave oscillator to produce multiple optical fields needed for the observation of the coherent population trapping (CPT). This effect allows very accurate measurement of the transition frequency between two ground state hyperfine sublevels (a "clock transition"), that can be used to construct a CPT-based atomic clock.
description: 10 pages, 10 figures
Conformational dynamics of A30G α-synuclein that causes familial Parkinson disease
Creators: name: Das, Dorothy
name: Mattaparthi, Venkata Satish Kumar
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Computational Biology

description: The first gene shown to be responsible for autosomal-dominant Parkinson’s disease (PD) is the SNCA gene, which encodes for alpha synuclein (α-Syn). Recently, a novel heterozygous A30G mutation of the SNCA gene associated with familial PD has been reported. However, little research has been done on how the A30G mutation affects the structure of α-Syn. So, using atomistic molecular dynamics (MD) simulation, we demonstrate here the key structural characteristics of A30G α-Syn in the free monomer form and membrane associated state. From the MD trajectory analysis, the structure of A30G α-Syn was noticed to exhibit rapid conformational change, increase in backbone flexibility near the site of mutation and decrease in α-helical propensity. The typical torsion angles in residues (Val26 and Glu28) near the mutation site were observed to deviate significantly in A30G α-Syn. In the case of membrane bound A30G α-Syn, the regions that were submerged in the lipid bilayer (N-helix (3-37) and turn region (38-44)) found to contain higher helical content than the elevated region above the lipid surface. The bending angle in the helix-N and helix-C regions were noticed to be relatively higher in the free form of A30G α-Syn (38.50) than in the membrane bound form (370). The A30G mutation in α-Syn was predicted to have an impact on the stability and function of the protein based on ΔΔG values obtained from the online servers. Our results demonstrate that the A30G mutation in α-Syn altered the protein’s α-helical structure and slightly altered the membrane binding. Communicated by Ramaswamy H. Sarma
A nonextensive approach for the instability of current-driven ion-acoustic waves in space plasma
Creators: name: Liu, Zhipeng
name: Liu, Liyan
name: Du, Jiulin
Publisher: name: arXiv
Year: 2009
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Geophysics (physics.geo-ph)
subject: FOS: Physical sciences

description: The instability of current-driven ion-acoustic waves in the collisionless magnetic-field-free space plasma is investigated by using a nonextensive approach. The ions and the electrons are thought of in the power-law distributions that can be described by the generalized q-Maxwellian velocity distribution and are considered with the different nonextensive q-parameters. The generalized q-wave frequency and the generalized instability q-growth rate for the ion-acoustic waves are derived. The numerical results show that the nonextensive effects on the ion-acoustic waves are not apparent when the electron temperature is much more than the ion temperature, but they are salient when the electron temperature is not much more than the ion temperature. As compared with the electrons, the ions play a dominant role in the nonextensive effects.
description: 12 pages, 4 figures, 20 references
Coevolutionary games - a mini review
Creators: name: Perc, Matjaz
name: Szolnoki, Attila
Publisher: name: arXiv
Year: 2009
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: Populations and Evolution (q-bio.PE)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Prevalence of cooperation within groups of selfish individuals is puzzling in that it contradicts with the basic premise of natural selection. Favoring players with higher fitness, the latter is key for understanding the challenges faced by cooperators when competing with defectors. Evolutionary game theory provides a competent theoretical framework for addressing the subtleties of cooperation in such situations, which are known as social dilemmas. Recent advances point towards the fact that the evolution of strategies alone may be insufficient to fully exploit the benefits offered by cooperative behavior. Indeed, while spatial structure and heterogeneity, for example, have been recognized as potent promoters of cooperation, coevolutionary rules can extend the potentials of such entities further, and even more importantly, lead to the understanding of their emergence. The introduction of coevolutionary rules to evolutionary games implies, that besides the evolution of strategies, another property may simultaneously be subject to evolution as well. Coevolutionary rules may affect the interaction network, the reproduction capability of players, their reputation, mobility or age. Here we review recent works on evolutionary games incorporating coevolutionary rules, as well as give a didactic description of potential pitfalls and misconceptions associated with the subject. In addition, we briefly outline directions for future research that we feel are promising, thereby particularly focusing on dynamical effects of coevolutionary rules on the evolution of cooperation, which are still widely open to research and thus hold promise of exciting new discoveries.
description: 24 two-column pages, 10 figures; accepted for publication in BioSystems
Towards a crop growth, development, and yield model for Lupinus angustifolius L. (narrow leafed lupin) in Tasmania
Creators: name: Bishop, A
Publisher: name: University Of Tasmania
Year: 2023

description: Experiments were conducted between 1988 and 1990 at Elliott, Cressy, and Ross in Tasmania using three cultivars (Yandee, Geebung, and 75A329) of narrow-leafed lupin (Lupinus angustifolius). The purpose of these experiments was to examine narrow-leafed lupin growth and development in Tasmania in relation to specific environmental factors. These factors were related to growth and development measurements. It was hoped to use these relationships in a simple crop model suitable for assessing sites for the commercial production of lupins. Preliminary experiments in 1988 examined the lupin cultivars for agronomic suitability in Tasmania. Increased grain yield was a function of more pods/m2 rather than increased pods/plant. This suggested that lower, yields of the indeterminate line 75A329 could be compensated for by a higher plant density than in the indeterminate cultivars. Lupins responded to higher rainfall and extended growing season at Elliott thus outyielding crops at Cressy and Ross. Detailed field experiments were conducted in 1989 and 1990 at Elliott and Cressy. Lupin crops developed very slowly in the first 8- 10 weeks, and then grew rapidly after flowering was initiated. It appeared floral initiation was a function of higher temperatures and longer days in Yandee and 75A329, with further responses to vernalisation in Geebung. Plant density significantly affected grain yield. 75A329 showed the largest yield responses to increased plant density. Although increased plant density resulted in increased leaf area, leaf senescence took place earlier in the highest density crops probably due to competitive effects. Optimum density for the indeterminate cultivars was 40 plants/m2. It may be higher for determinate cultivars. Low density crops were able to utilise their leaf area for light interception more efficiently than high density crops. In the latter, branches and leaves were pushed more towards vertical rather than horizontal thus less leaf area was presented to intercept light. The study established that early sowing of lupins in Tasmania allows more time to grow and develop and yield more grain. A direct relationship was established between increased total dry matter and increased grain yield. The model developed in this study used thermal time as its only external factor to determine L, intercepted radiation (%), and total dry matter (kg/ha) during crop growth. From the predicted figure for total dry matter accumulated by harvest time, an estimate of potential grain yield could be made for that crop. This study demonstrated the principle of collecting agronomic data and, guided by basic plant physiological principles and mathematical procedures, assembling simple sub-models that when linked can approximate a particular aspect of crop growth.
Additional file 13 of Switched alternative splicing events as attractive features in lung squamous cell carcinoma
Creators: name: He, Boxue
name: Wei, Cong
name: Cai, Qidong
name: Zhang, Pengfei
name: Shi, Shuai
name: Peng, Xiong
name: Zhao, Zhenyu
name: Yin, Wei
name: Tu, Guangxu
name: Peng, Weilin
name: Tao, Yongguang
name: Wang, Xiang
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 13: Figure S2. Relationships between clinical features and the risk model. The distribution of risk scores of LUSC patients in different clinical groups. LUSC patients were assigned to different groups according to clinical risk factors. (A) AJCC stage. (B) T stage. (C) N stage. (D) M stage. (E) Vital status. (F) Smoking history. (G) Gender. (H) Age.