cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Oncogenic Ras Blocks Anoikis by Activation of a Novel Effector Pathway Independent of Phosphatidylinositol 3-Kinase
Creators: name: Rogers-Graham, K.
name: McFall, A.
name: Ulku, A.
name: Lambert, Q. T.
name: Der, C. J.
name: Kusa, A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Activated Ras, but not Raf, causes transformation of RIE-1 rat intestinal epithelial cells, demonstrating the importance of Raf-independent effector signaling in mediating Ras transformation. To further assess the contribution of Raf-dependent and Raf-independent function in oncogenic Ras transformation, we evaluated the mechanism by which oncogenic Ras blocks suspension-induced apoptosis, or anoikis, of RIE-1 cells. We determined that oncogenic versions of H-, K-, and N-Ras, as well as the Ras-related proteins TC21 and R-Ras, protected RIE-1 cells from anoikis. Surprisingly, our analyses of Ras effector domain mutants or constitutively activated effectors indicated that activation of Raf-1, phosphatidylinositol 3-kinase (PI3K), or RalGDS alone is not sufficient to promote Ras inhibition of anoikis. Treatment of Ras-transformed cells with the U0126 MEK inhibitor caused partial reversion to an anoikis-sensitive state, indicating that extracellular signal-regulated kinase activation contributes to inhibition of anoikis. Unexpectedly, oncogenic Ras failed to activate Akt, and treatment of Ras-transformed RIE-1 cells with the LY294002 PI3K inhibitor did not affect anoikis resistance or growth in soft agar. Thus, while important for Ras transformation of fibroblasts, PI3K may not be involved in Ras transformation of RIE-1 cells. Finally, inhibition of epidermal growth factor receptor kinase activity did not overcome Ras inhibition of anoikis, indicating that this autocrine loop essential for transformation is not involved in anoikis protection. We conclude that a PI3K- and RalGEF-independent Ras effector(s) likely cooperates with Raf to confer anoikis resistance upon RIE-1 cells, thus underscoring the complex nature by which Ras transforms cells.
RBP1 Recruits the mSIN3-Histone Deacetylase Complex to the Pocket of Retinoblastoma Tumor Suppressor Family Proteins Found in Limited Discrete Regions of the Nucleus at Growth Arrest
Creators: name: Harlow, E.
name: Reinberg, D.
name: Kuzmichev, A.
name: Tsai, S.-C.
name: Seto, E.
name: Lai, A.
name: Barbie, D. A.
name: Theberge, M.-C.
name: Zhang, Y.
name: Kennedy, B. K.
name: Bertos, N. R.
name: Branton, P. E.
name: Lane, W. S.
name: Yang, X. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Retinoblastoma (RB) tumor suppressor family pocket proteins induce cell cycle arrest by repressing transcription of E2F-regulated genes through both histone deacetylase (HDAC)-dependent and -independent mechanisms. In this study we have identified a stable complex that accounts for the recruitment of both repression activities to the pocket. One component of this complex is RBP1, a known pocket-binding protein that exhibits both HDAC-dependent and -independent repression functions. RB family proteins were shown to associate via the pocket with previously identified mSIN3-SAP30-HDAC complexes containing exclusively class I HDACs. Such enzymes do not interact directly with RB family proteins but rather utilize RBP1 to target the pocket. This mechanism was shown to account for the majority of RB-associated HDAC activity. We also show that in quiescent normal human cells this entire RBP1-mSIN3-SAP30-HDAC complex colocalizes with both RB family members and E2F4 in a limited number of discrete regions of the nucleus that in other studies have been shown to represent the initial origins of DNA replication following growth stimulation. These results suggest that RB family members, at least in part, drive exit from the cell cycle by recruitment of this HDAC complex via RBP1 to repress transcription from E2F-dependent promoters and possibly to alter chromatin structure at DNA origins.
30 centimes pour mieux dormir en soins intensifs
Creators: name: Rohr, Vincent
name: Saugy, Adrien
Publisher: name: Unknown
Year: 0
Subjects: subject: qualité des soins
subject: sommeil
subject: milieu hospitalier
subject: soins intensifs

description: De nombreuses études démontrent que la qualité et la quantité de sommeil des patients hospitalisés en unités de soins intensifs sont grandement péjorées et ont de nombreuses répercussions sur la santé et le rétablissement des patients. De nombreux stimuli ont été identifiés, tels que le bruit, la lumière, l’inconfort et les interactions de soins.
description: Mémoire de Bachelor : Haute Ecole de la Santé La Source, 2013
Storia dell'esplorazione spaziale e media [poster]
Storia dell'esplorazione spaziale e media [poster]
Creators: name: Giaccio, Federica
Publisher: name: F. Giaccio, "Storia dell'esplorazione spaziale e media", in Anvedi che storia! VI Conferenza Nazionale AIPH. Dipartimento di Studi Umanistici, Università degli Studi Roma Tre. Roma, 10-14 giugno 2024.
Year: 2025

description: Immaginare il futuro dell'esplorazione spaziale è intrinseco nella natura umana; se già con le prime narrazioni scritte di viaggi interstellari emergono quesiti sulle prospettive dell'umanità, con i fumetti degli anni '50 inizia ad essere necessario visualizzare e concretizzare l'immaginazione.
Collection of case studies on academic career assessment - CoARA Working Group ACA
Creators: name: CoARA Working Group ACA
Publisher: name: Zenodo
Year: 2025
Subjects: CoARA
careers
reward
recognition
academic careers
research assessment

description: The CoARA Working Group on Reforming Academic Career Assessment (WG ACA) has developed a targeted mapping of initiatives on academic career assessment.

These files refer to a collection of case studies, which describe well-established international and national level initiatives for reforming research and academic career assessment.

Initiatives included in the case studies collection had an implementation plan targeted to all organisations conducting academic career assessments (recruitment, performance evaluation and/or career progression) within a country (national level) or irrespective of country (international). In addition, public documentation of the initiatives could be in any language, however in the case-study they need to be described in English.

A case-study template was used for describing the initiatives in a structured and comparable way. The following 11 case studies are included:

Initiative - name:

ANECA - Reforming research and academic careers assessment in Spain

CLACSO-FOLEC - Declaration of principles: a new research assessment towards a socially relevant science in Latin America and the Caribbean

CoARA - Coalition for Advancing Research Assessment (CoARA)

DORA - The San Francisco Declaration on Research Assessment (DORA)

EU Charter - The European Charter for Researchers

Finland - Good practice in researcher evaluation

Netherlands - Recognition & Rewards Programme

Norway - NOR-CAM – A toolbox for recognition and rewards in academic careers

OR4 - Open and Responsible Researcher Reward and Recognition (OR4)

UKRI - UKRI People and Teams Action Plan

YUFE4Postdocs - YUFE4Postdocs evaluation & selection procedure

A list of practical tools, which are part of the 11 initiatives described in the case studies, is also included, together with a summary and analysis of the case studies.

Additional related materials include a survey on academic career assessment (zenodo.org/records/14548157) and lessons learned from the case studies and survey (zenodo.org/records/14548106).
Effets de l'entraînement métacognitif sur la conscience des idées délirantes
Creators: name: Nicolier, Anouck
name: Perret, Marion
Publisher: name: Unknown
Year: 0
Subjects: subject: psychiatrie
subject: santé mentale
subject: délire
subject: entraînement cognitif

description: La conscience du trouble ou insight est un concept multidimensionnel. L’entraînement métacognitif (EMC) devrait améliorer spécifiquement la reconnaissance des idées délirantes comme faisant partie du trouble par rapport à l’acceptation de la maladie ou la reconnaissance du besoin de traitement. L’amélioration de cette variable ne devrait pas forcément conduire à la dépression. Méthode : 52 participants de 18 à 65 ans, remplissant les critères de la CIM 10 pour une schizophrénie ou un trouble schizo-affectif ont été répartis aléatoirement dans deux groupes, un recevant le traitement habituel (TH) et l’autre bénéficiant de l’EMC. Les patients ont été évalués avec la Scale to Assess Unawaereness of Mental Disorder (SUMD) avant la randomisation (T0), à la fin de l’EMC (T1) et 6 mois après le post-test (T2).
A Reduced Inner Product for Kink States
Creators: name: Evslin, Jarah
name: Liu, Hui
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Solitons in classical field theories correspond to states in quantum field theories. If the spatial dimension is infinite, then momentum eigenstates are not normalizable. This leads to infrared divergences, which are generally regularized via wave packets or by compactification. However, in some applications both possibilities are undesirable. In the present note, we introduce a finite inner product on translation-invariant kink states that allows us to compute probabilities involving these nonnormalizable states. Essentially, it is the quotient of the usual inner product by the translation group. We present a surprisingly simple formula for the reduced inner product, which requires no knowledge of the zero-mode dependence of the states but includes a correction which accounts for the mixing between zero modes and normal modes as the kink moves. As an application, we show that initial and final state corrections to meson multiplication vanish. However, we find that the pole of the subleading term in the initial state requires an infinitesimal imaginary shift.
description: 46 pages, no figures
Geodesic deviation in Saez--Ballester theory
Creators: name: Rasouli, S. M. M.
name: Sakellariadou, M.
name: Moniz, Paulo Vargas
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the geodesic deviation (GD) equation in a generalized version of the Sáez--Ballester (SB) theory in arbitrary dimensions. We first establish a general formalism and then restrict to particular cases, where (i) the matter-energy distribution is that of a perfect fluid, and (ii) the spacetime geometry is described by a vanishing Weyl tensor. Furthermore, we consider the spatially flat FLRW universe as the background geometry. Based on this setup, we compute the GD equation as well as the convergence condition associated with fundamental observers and past directed null vector fields. Moreover, we extend that framework and extract the corresponding geodesic deviation in the \emph{modified} Sáez--Ballester theory (MSBT), where the energy-momentum tensor and potential emerge strictly from the geometry of the extra dimensions. In order to examine our herein GD equations, we consider two novel cosmological models within the SB framework. Moreover, we discuss a few quintessential models and a suitable phantom dark energy scenario within the mentioned SB and MSBT frameworks. Noticing that our herein cosmological models can suitably include the present time of our Universe, we solve the GD equations analytically and/or numerically. By employing the correct energy conditions plus recent observational data, we consistently depict the behavior of the deviation vector $η(z)$ and the observer area distance $r_0(z)$ for our models. Concerning the Hubble constant problem, we specifically focus on the observational data reported by the Planck collaboration and the SH0ES collaboration to depict $η(z)$ and $r_0(z)$ for our herein phantom model. Subsequently, we contrast our results with those associated with the $Λ$CDM model.
description: 33 pages, 6 figures
Role of Phosphoinositide 3-Kinase in the Aggressive Tumor Growth of HT1080 Human Fibrosarcoma Cells
Creators: name: Whang, Y. E.
name: Stanbridge, E. J.
name: Plattner, R.
name: Tencati, M.
name: Gray, C.
name: Gupta, S.
name: Stuffrein, S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: We have developed a model system of human fibrosarcoma cell lines that do or do not possess and express an oncogenic mutant allele of N-ras. HT1080 cells contain an endogenous mutant allele of N-ras, whereas the derivative MCH603 cell line contains only wild-type N-ras. In an earlier study (S. Gupta et al., Mol. Cell. Biol. 20:9294–9306, 2000), we had shown that HT1080 cells produce rapidly growing, aggressive tumors in athymic nude mice, whereas MCH603 cells produced more slowly growing tumors and was termed weakly tumorigenic. An extensive analysis of the Ras signaling pathways (Raf, Rac1, and RhoA) provided evidence for a potential novel pathway that was critical for the aggressive tumorigenic phenotype and could be activated by elevated levels of constitutively active MEK. In this study we examined the role of phosphoinositide 3-kinase (PI 3-kinase) in the regulation of the transformed and aggressive tumorigenic phenotypes expressed in HT1080 cells. Both HT1080 (mutant N-ras) and MCH603 (wild-type N-ras) have similar levels of constitutively active Akt, a downstream target of activated PI 3-kinase. We find that both cell lines constitutively express platelet-derived growth factor (PDGF) and PDGF receptors. Transfection with tumor suppressor PTEN cDNA into HT1080 and constitutively active PI 3-kinase–CAAX cDNA into MCH603 cells, respectively, resulted in several interesting and novel observations. Activation of the PI 3-kinase/Akt pathway, including NF-κB, is not required for the aggressive tumorigenic phenotype in HT1080 cells. Activation of NF-κB is complex: in MCH603 cells it is mediated by Akt, whereas in HT1080 cells activation also involves other pathway(s) that are activated by mutant Ras. A threshold level of activation of PI 3-kinase is required in MCH603 cells before stimulatory cross talk to the RhoA, Rac1, and Raf pathways occurs, without a corresponding activation of Ras. The increased levels of activation seen were similar to those observed in HT1080 cells, except for Raf and MEK, which were more active than HT1080 levels. This cross talk results in conversion to the aggressive tumorigenic phenotype. This latter observation is consistent with our previous observation that overstimulation of the activity of endogenous members of Ras signaling pathways, activated MEK in particular, is a prerequisite for aggressive tumorigenic growth.
DEEP Projekt – Innovationen für die Minderung von Risiken bei tiefen Geothermieprojekten
Creators: name: Lanza, Federica
name: Link, Katharina
name: Wiemer, Stefan
name: Zingg, Olivier
Publisher: name: Zenodo
Year: 2022

description: Induzierte Seismizität beschäftigt die Geothermie-Branche schon seit längerer Zeit und wird auch in den kommenden zehn Jahren von zentraler Bedeutung bleiben – für die Sicherheit, gesellschaftliche Akzeptanz und Wirtschaftlichkeit vieler unterirdischer Anwendungen. Im Rahmen des laufenden «DEEP» Forschungsprojektes werden innovative Technologien entwickelt und optimierte Leitlinien und Protokolle bereitgestellt. Projektentwickler und -inhaber sind eingeladen, mit dem Projektteam Kontakt aufzunehmen.
Rethinking academic career assessment - Lessons and tools for reform (CoARA Working Group ACA)
Creators: name: CoARA Working Group ACA
Publisher: name: Zenodo
Year: 2024
Subjects: CoARA
reward
recognition
academic careers
research assessment

description: The CoARA Working Group on Reforming Academic Career Assessment (WG ACA) has developed a targeted mapping of initiatives on academic career assessment, which included a survey and case studies on academic career assessment initiatives.

This document outlines the key lessons learned from both the survey and case studies. It describes six lessons and insights to help guide comprehensive and structured reform ambitions, linking each lesson to specific case studies, survey outcomes and practical tools.

More information on the case studies is available at: zenodo.org/records/14548013

More information on the survey outcomes is available at: zenodo.org/records/14548157
L'infirmière, un pilier dans le monde si complexe de la maltraitance infantile
Creators: name: Nava, Florence
Publisher: name: Unknown
Year: 0
Subjects: subject: maltraitance
subject: enfant
subject: enfant maltraité
subject: prévention
subject: rôle infirmier
subject: milieu hospitalier

description: La question de recherche que j’ai établie pour mon Travail de Bachelor est la suivante : « Quelles sont les barrières que les infirmières, en milieu hospitalier, peuvent rencontrer et qui peuvent empêcher le signalement ou la dénonciation d’un cas de suspicion ou cas avéré de maltraitance ? Pouvons-nous les diminuer ? Ont-elles des besoins face à cette problématique ? »
description: Mémoire de Bachelor : Haute Ecole de la Santé La Source, 2013
Anomalous gapped boundaries between surface topological orders in higher-order topological insulators and superconductors with inversion symmetry
Creators: name: Li, Ming-Hao
name: Neupert, Titus
name: Parameswaran, S. A.
name: Tiwari, Apoorv
Publisher: name: arXiv
Year: 2022
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We show that the gapless boundary signatures - namely, chiral/helical hinge modes or localized zero modes - of three-dimensional higher-order topological insulators and superconductors with inversion symmetry can be gapped without symmetry breaking upon the introduction of non-Abelian surface topological order. In each case, the fractionalization pattern that appears on surface is `anomalous' in the sense that it can be made consistent with symmetry only on the surface of a three dimensional higher-order insulator/superconductor. Our results show that the interacting manifestation of higher-order topology is the appearance of `anomalous gapped boundaries' between distinct topological orders whose quasiparticles are related by inversion, possibly in conjunction with other protecting symmetries such as TRS and charge conservation.
description: 19 pages, 4 figures
title: Migration et fin de vie
title: le rôle infirmier auprès des personnes âgées migrantes en fin de vie
titleType: Subtitle
Creators: name: Moffrand, Marion
name: Schwitzguébel, Lydie
Publisher: name: Unknown
Year: 0
Subjects: subject: migrant
subject: rôle infirmier
subject: guerre
subject: fin de vie
subject: interculturalité
subject: situations de soins
subject: soins interculturels

description: Cette revue de la littérature explore les améliorations nécessaires pour la prise en charge infirmière des personnes migrantes âgées en situation de fin de vie. La vague migratoire survenue durant l’après guerre, en réponse au besoin de main d’oeuvre, représente aujourd’hui un enjeu sanitaire important. Les migrants restés en Suisse sont aujourd’hui en âge de la retraite et constituent une part considérable de la population vieillissante. Au vu de ce contexte démographique, les infirmiers-ères vont devoir de plus en plus faire face à des situations de fin de vie interculturelles.
description: Mémoire de Bachelor : Haute Ecole de la Santé La Source, 2013
title: Le soutien sanitaire opérationnel
title: des compétences infirmières au service des sapeurs-pompiers
titleType: Subtitle
Creators: name: Kiefer, Eve Alicia
name: Reymond, Fanny
Publisher: name: Unknown
Year: 0
Subjects: subject: soutien sanitaire
subject: sapeurs-pompiers
subject: astreintes physiologiques
subject: rôle infirmier

description: Ce travail est une revue partielle de la littérature scientifique, qui a pour but d’explorer des pistes d’interventions dans le cadre d’un soutien sanitaire opérationnel apporté aux sapeurs-pompiers volontaires et professionnels lors de la lutte contre l’incendie, afin de limiter les astreintes physiologiques auxquelles ils doivent faire face continuellement. Etant donné que ce type de mission s’est récemment développé en Suisse, nous avons voulu offrir aux infirmiers des réponses concrètes et applicables pour ce domaine de soin particulier.
description: Mémoire de Bachelor : Haute Ecole de la Santé La Source, 2013
General triple charged black ring solution in supergravity
Creators: name: Feldman, Andrew
name: Pomeransky, Andrei A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We present the general black ring solution in $U(1)^{3}$ supergravity in 5 dimensions with three independent dipole and electric charges. This immediately gives the general black ring solution in the minimal 5D supergravity as well.
description: 10 pages
Mapping academic career assessment reform initiatives - survey outcomes (CoARA Working Group ACA)
Creators: name: CoARA Working Group ACA
Publisher: name: Zenodo
Year: 2024
Subjects: CoARA
reward
recognition
academic careers
research assessment

description: The CoARA Working Group on Reforming Academic Career Assessment (WG ACA) has developed a targeted mapping of initiatives on academic career assessment, which included a survey and case studies on academic career assessment initiatives.

The survey gathered information on institutional/organisational level initiatives that aim to broaden the criteria and methods for evaluating the outputs and impacts of academic activities for the purposes of recruitment, performance evaluation and career progression of academic staff.

The survey was addressed to higher education and research organisations worldwide. It targeted organisations that were planning, initiating or implementing a reform process on academic career assessment - either at departmental/unit level or organisational level.

These files include the survey outcomes, questionnaire and dataset.

More information on the case studies is available at: zenodo.org/records/14548013

More information on the main lessons learned from the survey and case studies is available at: zenodo.org/records/14548106
The ordered exponential representation of GKM using the $W_{1+\infty}$ operator
Creators: name: Wang, Gehao
Publisher: name: arXiv
Year: 2022
Subjects: subject: Mathematical Physics (math-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Algebraic Geometry (math.AG)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: Primary 81R10, 81R12, 14H70, Secondary 17B68

description: The generalized Kontsevich model (GKM) is a one-matrix model with arbitrary potential. Its partition function belongs to the KP hierarchy. When the potential is monomial, it is an $r$-reduced tau-function that governs the $r$-spin intersection numbers. In this paper, we present an ordered exponential representation of monomial GKM in terms of the $W_{1+\infty}$ operators that preserves the KP integrability. In fact, this representation is naturally the solution of a $W_{1+\infty}$ constraint that uniquely determines the tau-function. Furthermore, we show that, for the cases of Kontsevich-Witten and generalized BGW tau-functions, their $W_{1+\infty}$ representations can be reduced to their cut-and-join representations under the reduction of the even time independence and Virasoro constraints.
description: 21 pages
Selective Inactivation of p53 Facilitates Mouse Epithelial Tumor Progression without Chromosomal Instability
Creators: name: Yin, C.
name: Lu, X.
name: Magrane, G.
name: Van Dyke, T.
name: Louis, D. N.
name: Gray, J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: We examined the selective pressure for, and the impact of, p53 inactivation during epithelial tumor evolution in a transgenic brain tumor model. In TgT121 mice, cell-specific inactivation of the pRb pathway in brain choroid plexus epithelium initiates tumorigenesis and induces p53-dependent apoptosis. We previously showed that p53 deficiency accelerates tumor growth due to diminished apoptosis. Here we show that in a p53+/− background, slow-growing dysplastic tissue undergoes clonal progression to solid angiogenic tumors in all animals. p53 is inactivated in all progressed tumors, with loss of the wild-type allele occurring in 90% of tumors. Moreover, similar progression occurs in 38% of TgT121p53+/+ mice, also with loss of at least one p53 allele and inactivation of p53. Thus, the selective pressure for p53 inactivation, likely based on its apoptotic function, is high. Yet, in all cases, p53 inactivation correlates with progression beyond apoptosis reduction, from dysplasia to solid vascularized tumors. Hence, p53 suppresses tumor progression in this tissue by multiple mechanisms. Previous studies of fibroblasts and hematopoietic cells show that p53 deficiency can be associated with chromosomal instability, a mechanism that may drive tumor progression. To determine whether genomic gains or losses are present in tumors that progress in the absence of p53, we performed comparative genomic hybridization analysis. Surprisingly, the only detectable chromosomal imbalance was partial or complete loss of chromosome 11, which harbors the p53 gene and is thus the selected event. Flow cytometry confirmed that the majority of tumor cells were diploid. These studies indicate that loss of p53 function is frequent under natural selective pressures and furthermore that p53 loss can facilitate epithelial tumor progression by a mechanism in addition to apoptosis reduction and distinct from chromosomal instability.
title: Don de rein vivant
title: un geste sans conséquences ?
titleType: Subtitle
Creators: name: Hugon, Alizé
name: Stolarska, Caroline
Publisher: name: Unknown
Year: 0
Subjects: subject: don d'organe
subject: rein
subject: psychologie
subject: accompagnement
subject: rôle infirmier

description: Ce travail de Bachelor repose sur la problématique concernant les possibles conséquences et/ou risques psychopathologiques lors du don de rein vivant et comment l’infirmière peut les appréhender au mieux. Cette thématique est apparue à la suite d’une expérience de stage vécue par l’une d’entre nous, puis par de nombreux échanges et débats sur la question.
description: Mémoire de Bachelor : Haute Ecole de la Santé La Source, 2013
Understanding Iterative Revision from Human-Written Text
Creators: name: Du, Wanyu
name: Raheja, Vipul
name: Kumar, Dhruv
name: Kim, Zae Myung
name: Lopez, Melissa
name: Kang, Dongyeop
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computation and Language (cs.CL)
subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: Writing is, by nature, a strategic, adaptive, and more importantly, an iterative process. A crucial part of writing is editing and revising the text. Previous works on text revision have focused on defining edit intention taxonomies within a single domain or developing computational models with a single level of edit granularity, such as sentence-level edits, which differ from human's revision cycles. This work describes IteraTeR: the first large-scale, multi-domain, edit-intention annotated corpus of iteratively revised text. In particular, IteraTeR is collected based on a new framework to comprehensively model the iterative text revisions that generalize to various domains of formal writing, edit intentions, revision depths, and granularities. When we incorporate our annotated edit intentions, both generative and edit-based text revision models significantly improve automatic evaluations. Through our work, we better understand the text revision process, making vital connections between edit intentions and writing quality, enabling the creation of diverse corpora to support computational modeling of iterative text revisions.
description: To appear in ACL2022
Production of black holes and string balls in a two-dimensional split-fermion model
Creators: name: Abdolrahimi, Shohreh
name: Tzounis, Christos
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We present cross-sections for the black hole and string ball production in proton-proton collisions in a TeV-scale gravity model with split fermions in two dimensions. The cross-section for black hole and string ball production in the split-fermion model is smaller than in the non-split-fermion model. The drop of the cross-section for the string ball production can be one to two orders of magnitude with the increase of the width of the brane from $L=0$ to 15 $\text{TeV}^{-1}$. The cross-section for string ball production in two-dimensional split fermion model reduces more in comparison to black holes. Black holes are quite hard to be observed at the LHC. In fact, taking into account the current experimental limits on the fundamental Planck scale, black holes cannot be produced at the LHC. Cross-section for string ball production depends significantly on string coupling constant, making it very model dependent. We investigate the range of values of string coupling constant from 0.02 to 0.4. There has been no evidence for production of string balls at $\sqrt{s}=8$ TeV. A two-dimensional split fermion model with a extremely thick brane can account for the absence of signature of string balls for a world with the value of fundamental Planck scale even as low as 1 TeV.
description: 28 pages 18 figures
Modular matrices from universal wave function overlaps in Gutzwiller-projected parton wave functions
Creators: name: Mei, Jia-Wei
name: Wen, Xiao-Gang
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We implement the universal wave function overlap (UWFO) method to extract modular $S$ and $T$ matrices for topological orders in Gutzwiller-projected parton wave functions (GPWFs). The modular $S$ and $T$ matrices generate a projective representation of $SL(2,\mathbb{Z})$ on the degenerate-ground-state Hilbert space on a torus and may fully characterize the 2+1D topological orders, i.e. the quasi-particle statistics and chiral central charge (up to $E_8$ bosonic quantum Hall states). We used the variational Monte Carlo method to computed the $S$ and $T$ matrices of the chiral spin liquid (CSL) constructed by the GPWF on the square lattice, and confirm that the CSL carries the same topological order as the $ν=\frac{1}{2}$ bosonic Laughlin state. We find that the non-universal exponents in UWFO can be small and direct numerical computation is able to be applied on relatively large systems. We also discuss the UWFO method for GPWFs on other Bravais lattices in two and three dimensions by using the Monte Carlo method. UWFO may be a powerful method to calculate the topological order in GPWFs.
description: 5 pages with 3 figures
The Insert Region of Rac1 Is Essential for Membrane Ruffling but Not Cellular Transformation
Creators: name: Der, C. J.
name: Campbell, S. L.
name: Karnoub, A. E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: The Rho family of Ras-related proteins, which includes Rac1, RhoA, and Cdc42, is distinguished from other members of the Ras superfamily of small GTPases in that its members possess additional sequences positioned between β-strand 5 and α-helix 4, designated the insert region. Previous studies have established the importance of an intact insert region for the transforming, but not actin cytoskeletal reorganization, activities of Cdc42 and RhoA. Similarly, the insert region was determined to be essential for Rac1-mediated mitogenesis. Additionally, an intact insert region was also determined to be required for the antiapoptotic activity of Rac1 as well as for Rac1 activation of reactive oxygen species and the NF-κB transcription factor. However, it has not been determined whether the insert region is important for Rac1-mediated growth transformation. In this study, we assessed the requirement for the insert region in Rac1 transformation and signaling in NIH 3T3 cells. Unexpectedly, we found that a mutant of constitutively activated Rac1 that lacked the insert region retained potent transforming activity. The insert region of Rac1 was dispensable for Rac1 stimulation of transcription from the cyclin D1 promoter and for activation of the c-Jun, NF-κB, and E2F-1 transcription factors but was essential for Rac1 induction of serum response factor activity. While an intact insert region was dispensable for inducing reactive oxygen species production in vivo, it was required for Rac1 induction of lamellipodia. When taken together, these results show that the insert region of Rac1 serves roles in regulating actin organization and cell growth that are distinct from those of the analogous regions of Cdc42 and RhoA and support its involvement in regulating specific downstream effector interactions.
The Putative Oncoprotein Bcl-3 Induces Cyclin D1 To Stimulate G1 Transition
Creators: name: Hanson, J. L.
name: Baldwin, A. S.
name: Anest, V.
name: Mayo, M. W.
name: Westerheide, S. D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Bcl-3 is a distinctive member of the IκB family of NF-κB inhibitors because it can function to coactivate transcription. A potential involvement of Bcl-3 in oncogenesis is highlighted by the fact that it was cloned due to its location at a breakpoint junction in some cases of human B-cell chronic lymphocytic leukemia and that it is highly expressed in human breast tumor tissue. To analyze the effects of Bcl-3 dysregulation in breast epithelial cells, we created stable immortalized human breast epithelial cell lines either expressing Bcl-3 or carrying the corresponding vector control plasmid. Analysis of the Bcl-3-expressing cells suggests that these cells have a shortened G1 phase of the cell cycle as well as a significant increase in hyperphosphorylation of the retinoblastoma protein. Additionally, the cyclin D1 gene was found to be highly expressed in these cells. Upon further analysis, Bcl-3, acting as a coactivator with NF-κB p52 homodimers, was demonstrated to directly activate the cyclin D1 promoter through an NF-κB binding site. Therefore, our results demonstrate that dysregulated expression of Bcl-3 potentiates the G1 transition of the cell cycle by stimulating the transcription of the cyclin D1 gene in human breast epithelial cells.
Learning Bidirectional Translation between Descriptions and Actions with Small Paired Data
Creators: name: Toyoda, Minori
name: Suzuki, Kanata
name: Hayashi, Yoshihiko
name: Ogata, Tetsuya
Publisher: name: arXiv
Year: 2022
Subjects: subject: Robotics (cs.RO)
subject: Artificial Intelligence (cs.AI)
subject: Computation and Language (cs.CL)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: This study achieved bidirectional translation between descriptions and actions using small paired data from different modalities. The ability to mutually generate descriptions and actions is essential for robots to collaborate with humans in their daily lives, which generally requires a large dataset that maintains comprehensive pairs of both modality data. However, a paired dataset is expensive to construct and difficult to collect. To address this issue, this study proposes a two-stage training method for bidirectional translation. In the proposed method, we train recurrent autoencoders (RAEs) for descriptions and actions with a large amount of non-paired data. Then, we finetune the entire model to bind their intermediate representations using small paired data. Because the data used for pre-training do not require pairing, behavior-only data or a large language corpus can be used. We experimentally evaluated our method using a paired dataset consisting of motion-captured actions and descriptions. The results showed that our method performed well, even when the amount of paired data to train was small. The visualization of the intermediate representations of each RAE showed that similar actions were encoded in a clustered position and the corresponding feature vectors were well aligned.
description: 8 pages, 7 figures. To appear in IEEE Robotics and Automation Letters (RA-L) and the 2022 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS 2022). An accompanying video is available at https://youtu.be/YlxM_kw6YLE
Quelles barrières individuelles et organisationnelles entravent la volonté des infirmières à faire un report des erreurs médicamenteuses et quelles stratégies doivent être mises en place pour dépasser ces barrières dans le but d’augmenter la qualité des soins et la sécurité du patient ?
Creators: name: Hercod, Sylvain
name: Surdez, Kriss
Publisher: name: Unknown
Year: 0
Subjects: subject: erreur
subject: administration médicamenteuse
subject: médicament
subject: rapport
subject: qualité des soins
subject: rôle infirmier

description: Les erreurs médicamenteuses surviennent fréquemment à l’hôpital et engendrent de lourdes pertes humaines et financières. Le meilleur moyen de les prévenir est d’avoir des stratégies adéquates pour empêcher leur survenue. Ces dernières doivent être adaptées aux besoins des professionnels dans leur milieu de soins spécifiques. Pour y parvenir, il est important de pouvoir analyser les données comprenant les facteurs ayant contribués à l’apparition de l’erreur. C’est pourquoi, il est indispensable que les infirmières signalent les erreurs commises afin d’alimenter cette base de données. Actuellement, le taux de report est encore jugé trop faible pour pouvoir en extraire des données pertinentes.
description: Mémoire de Bachelor : Haute Ecole de la Santé La Source, 2013
From algebraic curve to minimal surface and back
Creators: name: Cooke, Michael
name: Drukker, Nadav
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We derive the Lax operator for a very large family of classical minimal surface solutions in $AdS_3$ describing Wilson loops in $\mathcal{N}=4$ SYM theory. These solutions, constructed by Ishizeki, Kruczenski and Ziama, are associated with a hyperellictic surface of odd genus. We verify that the algebraic curve derived from the Lax operator is indeed none-other than this hyperelliptic surface.
description: 21 pages
Two Distinct Domains within CIITA Mediate Self-Association: Involvement of the GTP-Binding and Leucine-Rich Repeat Domains
Creators: name: Ting, J. P.-Y.
name: Martin, B. K.
name: Harton, J. A.
name: Linhoff, M. W.
name: Cressman, D. E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: CIITA is the master regulator of class II major histocompatibility complex gene expression. We present evidence that CIITA can self-associate via two domains: the C terminus (amino acids 700 to 1130) and the GTP-binding domain (amino acids 336 to 702). Heterotypic and homotypic interactions are observed between these two regions. Deletions within the GTP-binding domain that reduce GTP-binding and transactivation function also reduce self-association. In addition, two leucine residues in the C-terminal leucine-rich repeat region are critical for self-association as well as function. This study reveals for the first time a complex pattern of CIITA self-association. These interactions are discussed with regard to the apoptosis signaling proteins, Apaf-1 and Nod1, which share domain arrangements similar to those of CIITA.
An assessment of a natural wetland receiving sewage effluent
Creators: name: Finlayson, Max
name: Cullen, Peter
name: Mitchell, David
name: Chick, Alan
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

An assessment of the performance of a wetland dominated by opportunistic weeds in removing nutrients from a secondary sewage effluent was carried out at Thredbo in Kosciusko National Park. Water quality sampling of the inflow and outflow showed a reduction in turbidity, pH and conductivity with passage through the wetland. Dissolved oxygen levels also decreased. In summer 1982, the phosphorus load of 1.8kg P day-1 was reduced by 44% as wasterwater moved through the wetland, and the nitrogen load of 6.4 kg N day-1 by 65%. Winter retentions were 10% and 14% of inflowing loads, respectively. In 1983 there was a net release of phosphorus and reduced retention of nitrogen. This was regarded as being a result of physical distrubance of the wetland. Vegetation downstream of the effluent inflow was dominated by the opportunistic weeds Epilobium sarmantaceum and Rumex crispus. Upstream, Carex gaudichaudiana and Baeckea gunniana dominated. Marked seasonal changes in vigour and biomass were recorded. Plants, but not sediments, downstream of the inflow contained more nutrients than those upstream. Seed bank analysis showed more seeds downstream than upstream. A moist treatment promoted more seed germination than a flooded treatment. E. sarmantaceum and to a lesser extent R. crispus dominated in each treatment. In an effort to promote greater water retention and replacement of the weed species, channels in the wetland have been blocked with gravel and planted with Phragmites australis and Schoenoplectus validus.
(:unas) unassigned
Creators: name: (:Unkn) Unknown
Publisher: name: Universita' degli Studi di Salerno
Year: 2024

description: Il seguente articolo nasce come riflessione a partire dall’analisi diretta di alcuni documenti raccolti da Edoardo Sanguineti (recensioni, saggi e scambi epistolari) e relativi a Il Giuoco dell’Oca. Tale ricognizione critica cerca, in particolare, di ricostruire la temperie storico-culturale in cui è andato a collocarsi il secondo romanzo sanguinetiano, non senza rinunciare ad uno sguardo sulla contemporaneità e a riletture originali.
description: The following article starts from a direct analysis of some documents collected by Edoardo Sanguineti (reviews, essays and letters) and referred to Il Giuoco dell’Oca. This critical reconstruction tries, in particular, to rediscover the historical and cultural environment in which Sanguineti’s second romance placed itself, also looking at contemporary studies and seeking for new perspectives.
3' End Processing of Drosophilamelanogaster Histone Pre-mRNAs: Requirement for Phosphorylated Drosophila Stem-Loop Binding Protein and Coevolution of the Histone Pre-mRNA Processing System
Creators: name: Dominski, Z.
name: Duronio, R. J.
name: Raska, C. S.
name: Borchers, C. H.
name: Marzluff, W. F.
name: Santiago, C.
name: Yang, X.-c.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Synthetic pre-mRNAs containing the processing signals encoded by Drosophila melanogaster histone genes undergo efficient and faithful endonucleolytic cleavage in nuclear extracts prepared from Drosophila cultured cells and 0- to 13-h-old embryos. Biochemical requirements for the in vitro cleavage are similar to those previously described for the 3′ end processing of mammalian histone pre-mRNAs. Drosophila 3′ end processing does not require ATP and occurs in the presence of EDTA. However, in contrast to mammalian processing, Drosophila processing generates the final product ending four nucleotides after the stem-loop. Cleavage of the Drosophila substrates is abolished by depleting the extract of the Drosophila stem-loop binding protein (dSLBP), indicating that both dSLBP and the stem-loop structure in histone pre-mRNA are essential components of the processing machinery. Recombinant dSLBP expressed in insect cells by using the baculovirus system efficiently complements the depleted extract. Only the RNA-binding domain plus the 17 amino acids at the C terminus of dSLBP are required for processing. The full-length dSLBP expressed in insect cells is quantitatively phosphorylated on four residues in the C-terminal region. Dephosphorylation of the recombinant dSLBP reduces processing activity. Human and Drosophila SLBPs are not interchangeable and strongly inhibit processing in the heterologous extracts. The RNA-binding domain of the dSLBP does not substitute for the RNA-binding domain of the human SLBP in histone pre-mRNA processing in mammalian extracts. In addition to the stem-loop structure and dSLBP, 3′ processing in Drosophila nuclear extracts depends on the presence of a short stretch of purines located ca. 20 nucleotides downstream from the stem, and an Sm-reactive factor, most likely the Drosophila counterpart of vertebrate U7 snRNP.
L'infirmière au coeur du défi quotidien des familles d'un enfant atteint de mucoviscidose
Creators: name: Grossenbacher, Laura
Publisher: name: Unknown
Year: 0
Subjects: subject: mucoviscidose
subject: enfant
subject: famille
subject: accompagnement
subject: vie quotidienne
subject: rôle infirmier

description: Cette revue de littérature a été réalisée dans le but de comprendre quels sont les facteurs compromettant le bien-être quotidien des familles d’un enfant atteint de mucoviscidose, de comprendre quelles stratégies elles mettent en place afin de leur faire face et de proposer des interventions infirmières appropriées, afin d’aider les parents à confronter au quotidien la maladie de leur enfant à domicile. Ma question de recherche est la suivante : quelles interventions infirmières privilégier pour aider, de manière optimale, les parents d’un enfant atteint de mucoviscidose à assumer au quotidien la maladie de leur enfant à domicile, et de ce fait favoriser le maintien du bien-être familial ?
description: Mémoire de Bachelor : Haute Ecole de la Santé La Source, 2013
Spintronic magnetic anisotropy
Creators: name: Misiorny, Maciej
name: Hell, Michael
name: Wegewijs, Maarten R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: An attractive feature of magnetic adatoms and molecules for nanoscale applications is their superparamagnetism, the preferred alignment of their spin along an easy axis preventing undesired spin reversal. The underlying magnetic anisotropy barrier --a quadrupolar energy splitting-- is internally generated by spin-orbit interaction and can nowadays be probed by electronic transport. Here we predict that in a much broader class of quantum-dot systems with spin larger than one-half, superparamagnetism may arise without spin-orbit interaction: by attaching ferromagnets a spintronic exchange field of quadrupolar nature is generated locally. It can be observed in conductance measurements and surprisingly leads to enhanced spin filtering even in a state with zero average spin. Analogously to the spintronic dipolar exchange field, responsible for a local spin torque, the effect is susceptible to electric control and increases with tunnel coupling as well as with spin polarization.
description: 6 pages with 4 figures + 26 pages of Supplementary Information
The entropic $g$-theorem in general spacetime dimension
Creators: name: Casini, Horacio
name: Landea, Ignacio Salazar
name: Torroba, Gonzalo
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We establish the irreversibility of renormalization group flows on a pointlike defect inserted in a $d$-dimensional Lorentzian conformal field theory. We identify the impurity entropy $g$ with the quantum relative entropy in two equivalent ways. One involves a null deformation of the Cauchy surface, and the other is given in terms of a local quench protocol. Positivity and monotonicity of the relative entropy imply that $g$ decreases monotonically along renormalization group flows, and provides a clear information-theoretic meaning for this irreversibility.
description: v2: minor corrections, matches published version. 6 pages, 2 figures