cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Intermittent compression of N-alkyl-N,N-dimethylamine N-oxides encapsulated in a container with bis[2]catenane topology
Creators: name: Galan, Albano
name: Espelt, Monica
name: Ballester, Pablo
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: 60506 Virology
subject: FOS: Biological sciences

description: We report the encapsulation of a homologous series of N-alkyl-N,N-dimethylamine N-oxides in a molecular container with bis[2]catenane topology. N-oxides with short alkyl chains are co-encapsulated with one solvent molecule. Elongation of the alkyl chain from R = methyl to pentyl produced the progressive compression of the guest. The hexyl N-oxide reduces its compression by being singly encapsulated. Longer N-oxides (R = octyl to decyl) had to fold to adapt to the capsule’s dimensions and also experience a progressive compression. The mechanically interlocked nature of the container and the polar functionalisation of its cavity are responsible for the assembly of encapsulation complexes in solution displaying high packing coefficients (0.65–0.70). The high energy conformations adopted by the alkyl chains of the bound N-oxides are deduced from NMR experiments and molecular modelling studies.
Preferences for potential innovations in non-invasive colorectal cancer screening: A labeled discrete choice experiment for a Dutch screening campaign
Creators: name: Benning, Tim M.
name: Dellaert, Benedict G. C.
name: Dirksen, Carmen D.
name: Severens, Johan L.
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Chemistry
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Physiology

description: Background. The introduction of innovative non-invasive screening tests (e.g. tests based on stool and blood samples or both) may be a solution to increase colorectal cancer (CRC) screening uptake. However, preferences for these non-invasive screening tests have not been investigated in great detail yet. The purpose of this article therefore is to elicit individuals’ preferences for different non-invasive screening tests in a Dutch screening campaign context.Material and methods. We investigate preferences by means of a labeled discrete choice experiment. Data of 815 individuals, aged 55–75 years, are used in the analysis.Results. Multinomial logit model analysis showed that the combi-test is generally preferred over the blood-test and the (currently available) stool-test. Furthermore, besides the large effect of screening test type, there are significant differences in preference depending on participants’ socio-demographic background. Finally, the analysis showed a significant positive effect on screening test choice for the attributes sensitivity, risk reduction, and level of evidence and a non-significant effect for the attribute unnecessary follow-up test.Conclusion. Introducing new non-invasive screening tests that are based on a combination of stool and blood samples (or blood sample only) has the potential to increase CRC screening participation compared to the current standard stool-based test.
Intermittent compression of N-alkyl-N,N-dimethylamine N-oxides encapsulated in a container with bis[2]catenane topology
Creators: name: Galan, Albano
name: Espelt, Monica
name: Ballester, Pablo
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: 60506 Virology
subject: FOS: Biological sciences

description: We report the encapsulation of a homologous series of N-alkyl-N,N-dimethylamine N-oxides in a molecular container with bis[2]catenane topology. N-oxides with short alkyl chains are co-encapsulated with one solvent molecule. Elongation of the alkyl chain from R = methyl to pentyl produced the progressive compression of the guest. The hexyl N-oxide reduces its compression by being singly encapsulated. Longer N-oxides (R = octyl to decyl) had to fold to adapt to the capsule’s dimensions and also experience a progressive compression. The mechanically interlocked nature of the container and the polar functionalisation of its cavity are responsible for the assembly of encapsulation complexes in solution displaying high packing coefficients (0.65–0.70). The high energy conformations adopted by the alkyl chains of the bound N-oxides are deduced from NMR experiments and molecular modelling studies.
Bioethanol scheduling production with a combination of oil palm trunksand empty fruit bunches
Creators: name: Thongchai R.Srinophakun
Publisher: name: Asia-Pacific Journal of Science and Technology
Year: 2022
Subjects: Bioethanol production, Oil palm trunks, Empty fruit bunches, Scheduling, Aspen batch process developer

description: Asia-Pacific Journal of Science and Technology, 27, 2, 7
Hydrogen-bonded hexameric cluster of benzyl alcohol in the solid state polymeric organization of p-tert-Butylcalix[5]arene
Creators: name: Kajiki, Yasunori
name: Sekiya, Ryo
name: Takeharu Haino
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: An uncommon hydrogen-bonded hexameric cluster of benzyl alcohol (2) was formed in hydrophobic space in the layered organisation of the one-dimensional polymeric zigzag array of 1 in the solid state. The hexameric cluster adopted a distorted cyclohexane-like (12) O–H⋯O hydrogen bond network. The formation of the hexameric cluster was quite sensitive to a tiny structural difference of guests; phenylethylalcohol (3), phenol (4), benzyl amine (5) and aniline (6) did not form any hexameric cluster. The packing coefficient of 0.53 suggested that the hexameric cluster nicely filled the hydrophobic space, which most likely resulted in the effective van der Waals contacts that stabilised the supramolecular organisation composed of the hexameric cluster and the polymeric array of 1 in the solid state.
Environmental and economic analysis of a biodiesel power plant derived from the fast pyrolysis of empty fruit bunches
Creators: name: Thongchai R.Srinophakun
Publisher: name: Asia-Pacific Journal of Science and Technology
Year: 2022
Subjects: Aspen plus process modelling, Bio-oil production process, Bio-oil upgrading process, Empty fruit bunches, Fast pyrolysis

description: Asia-Pacific Journal of Science and Technology, 27, 2, 9
Enhanced antioxidant activity of pericarp extract from black Dimocarpus longan Lour
Creators: name: Wantida Chaiyan
Publisher: name: Asia-Pacific Journal of Science and Technology
Year: 2022
Subjects: Dimocarpus longan, Antioxidant, Phenolic content, Gallic acid

description: Asia-Pacific Journal of Science and Technology, 27, 2, 8
Impact of advancing age on treatment and outcomes in anal cancer
Creators: name: Leong, Trevor
name: Foo, Marcus
name: Link, Emma
name: Chu, Julie
name: Lee, Mark T.
name: Sarat Chander
name: Tran, Phillip K.
name: Tomaszewski, Jonathan M.
name: Michael, Michael
name: Heriot, Alexander
name: Ngan, Samuel Y.
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Cancer
Biological Sciences
Biotechnology
Cell Biology
Medicine

description: Background. Chemoradiotherapy (CRT) for squamous cell carcinoma of the anus (SCCA) may cause significant toxicity, and concerns exist about its tolerability in the elderly. The authors compared tolerability and outcomes across the age groups following CRT for SCCA.Methods. Single-institution retrospective analysis of patients with localized SCCA treated with CRT. CRT was standardized at 50.4–54 Gy, with concurrent infusional 5-fluorouracil and mitomycin C. Patients were arbitrarily categorized into three groups: Group 1 – age < 50 years; Group 2 – age ≥ 50 and < 70 years; and Group 3 – age ≥ 70 years.Results. Of 284 patients identified, 278 were evaluable. The number of patients in each age group was: Group 1 – 51; Group 2 – 140; and Group 3 – 93. Baseline and treatment characteristics, tumor stage, rates of overall acute toxicity, need for unplanned treatment breaks and chemotherapy delivery were largely similar across the age groups. However, nine patients in Group 3 did not complete CRT, compared with five and none in Groups 1 and 2, respectively (p = 0.006). In addition, five patients in Group 3 had diarrhea requiring treatment break, compared with none in the other two groups (p = 0.004). At a median follow-up 5.3 years, there was no significant difference in overall survival (p = 0.11), disease-free survival (p = 0.22) or local-recurrence free survival (p = 0.34), across the three age groups.Conclusions. CRT is safe and tolerable in the elderly age group, and provides equivalent disease control rates compared with the younger age group. Age alone should therefore not preclude aggressive curative treatment.
Vermicompost efficacyin improvement of cucumber (Cucumis sativusL.) productivity, soilnutrients,and bacterial populationunder greenhouse condition
Creators: name: Panida Duangkaew
Publisher: name: Asia-Pacific Journal of Science and Technology
Year: 2022
Subjects: Cucumber,Productivity, Soil nutrients, Vermicompost

description: Asia-Pacific Journal of Science and Technology, 27, 2, 9
Isolation of bacteria utilizing glycerol as a sole carbon source for potential production of 1,3-propanediol
Creators: name: Atcha Oraintara
Publisher: name: Asia-Pacific Journal of Science and Technology
Year: 2022
Subjects: 1,3-Propanediol, Glycerol utilizing bacteria, Klebsiella pneumoniae, 1,3-propanediol oxidoreductase

description: Asia-Pacific Journal of Science and Technology, 27, 2, 8
The predictive value of KRAS, NRAS, BRAF, PIK3CA and PTEN for anti-EGFR treatment in metastatic colorectal cancer: A systematic review and meta-analysis
Creators: name: Therkildsen, Christina
name: Bergmann, Troels K.
name: Ladelund, Steen
name: Mef Nilbert
name: Henrichsen-Schnack, Tine
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Hematology
subject: Cancer
subject: Chemistry
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biophysics

description: Background. In metastatic colorectal cancer, mutation testing for KRAS exon 2 is widely implemented to select patients with wild-type tumors for treatment with the monocloncal anti-EGFR antibodies cetuximab and panitumumab. The added predictive value of additional biomarkers in the RAS-RAF-MAPK and PI3K-AKT-mTOR pathways in colorectal cancer is uncertain, which led us to systematically review the impact of alterations in KRAS (outside of exon 2), NRAS, BRAF, PIK3CA and PTEN in relation to the clinical benefit from anti-EGFR treatment.Methods. In total, 22 studies that include 2395 patients formed the basis for a meta-analysis on alterations in KRAS exons 3 and 4, NRAS, BRAF, and PIK3CA and PTEN and outcome of anti-EGFR treatment. Odds ratios for objective response rate (ORR) and hazard ratios (HR) for progression-free survival (PFS) and overall survival (OS) were calculated.Results. Mutations in KRAS exons 3 and 4, BRAF, PIK3CA and non-functional PTEN (mutations or loss of protein expression) significantly predicted poor ORR (OR = 0.26, OR = 0.29, OR = 0.39, and OR = 0.41, respectively). Significantly shorter PFS applied to mutations in KRAS exons 3 and 4 (HR = 2.19), NRAS (HR = 2.30) and BRAF (HR = 2.95) and non-functional PTEN (HR = 1.88). Significantly shorter OS applied to mutations in KRAS exons 3 and 4 (HR = 1.78), NRAS (HR = 1.85), BRAF (HR = 2.52), PIK3CA (HR = 1.43) and alterations in PTEN (HR = 2.09).Conclusions. Meta-analysis suggests that mutations in KRAS exons 3 and 4, NRAS, BRAF and PIK3CA and non-functional PTEN predict resistance to anti-EGFR therapies and demonstrates that biomarker analysis beyond KRAS exon 2 should be implemented for prediction of clinical benefit from anti-EGFR antibodies in metastatic colorectal cancer.
Potential antioxidant, anti-aging enzymes, and anti-tyrosinase propertiesof Macadamia (Macadamia integrifolia) pericarp waste products
Creators: name: Wantida Chaiyana
Publisher: name: Asia-Pacific Journal of Science and Technology
Year: 2022
Subjects: Antioxidant, Anti-ageing, Anti-tyrosinase, Cosmeceutical, Macadamia integrifolia

description: Asia-Pacific Journal of Science and Technology, 27, 2, 8
Chest (Medical illustrations)
Creators: name: Francone, Clarice Ashworth
Publisher: name: Oregon Health & Science University
Year: 0
Subjects: Medical Illustration
Thorax
Rib Cage
Thoracic Surgery
Skull

description: Forty pencil sketches of the chest, mostly of the skeletal structure of the ribcage. Also includes sketches of surgery on the chest, organs behind the ribcage and the skeletal structure of the chest and skull.
Co-digestion of sugarcane bagasse, microalgal biomass and cow dung for biohydrogen and methane production
Creators: name: Apilak Salakkam
Publisher: name: Asia-Pacific Journal of Science and Technology
Year: 2022
Subjects: D-optimal mixture design,Co-digestion, Renewable energy, Dark fermentation, Methanogenesis,Vermihumus

description: Asia-Pacific Journal of Science and Technology, 27, 2, 12
Preferences for potential innovations in non-invasive colorectal cancer screening: A labeled discrete choice experiment for a Dutch screening campaign
Creators: name: Benning, Tim M.
name: Dellaert, Benedict G. C.
name: Dirksen, Carmen D.
name: Severens, Johan L.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Chemistry
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Physiology

description: Background. The introduction of innovative non-invasive screening tests (e.g. tests based on stool and blood samples or both) may be a solution to increase colorectal cancer (CRC) screening uptake. However, preferences for these non-invasive screening tests have not been investigated in great detail yet. The purpose of this article therefore is to elicit individuals’ preferences for different non-invasive screening tests in a Dutch screening campaign context.Material and methods. We investigate preferences by means of a labeled discrete choice experiment. Data of 815 individuals, aged 55–75 years, are used in the analysis.Results. Multinomial logit model analysis showed that the combi-test is generally preferred over the blood-test and the (currently available) stool-test. Furthermore, besides the large effect of screening test type, there are significant differences in preference depending on participants’ socio-demographic background. Finally, the analysis showed a significant positive effect on screening test choice for the attributes sensitivity, risk reduction, and level of evidence and a non-significant effect for the attribute unnecessary follow-up test.Conclusion. Introducing new non-invasive screening tests that are based on a combination of stool and blood samples (or blood sample only) has the potential to increase CRC screening participation compared to the current standard stool-based test.
REPURPOSING METFORMIN WITH ELECTRICAL PULSES FOR TRIPLE-NEGATIVE BREAST CANCER APPLICATIONS: NOVEL IN-VITRO STUDIES
Creators: name: Sahu, Praveen
Publisher: name: Purdue University Graduate School
Year: 2025
Subjects: classificationCode: 400899
subject: Electrical engineering not elsewhere classified
classificationCode: 321199
subject: Oncology and carcinogenesis not elsewhere classified
classificationCode: 400399
subject: Biomedical engineering not elsewhere classified

description: Triple Negative Breast Cancer (TNBC) is an aberrant type of breast cancer subset that lacks traditional biomarkers (e.g., estrogen receptor (ER), progesterone receptor (PR)) and shows no upregulation in HER2 protein (human epidermal growth factor receptor 2). It is particularly aggressive due to the absence of three key receptors (ER, PR, and HER2 protein), resulting in limited treatment options and a higher risk of metastasis, recurrence, and mortality. Thus, there is a need for alternative therapies. Towards this, we studied the antiproliferation characteristics of electrical pulse-mediated therapy using Metformin, a commonly used Type-2 diabetes drug, alone and in combination with Cisplatin. This research demonstrates the novel repurposing of
Metformin, an affordable, FDA-approved, and widely used anti-diabetic drug, on MDA-MB-231 and MDA-MB-468 human TNBC cells. For the first time, we explore the impact of combining Metformin with electrical pulses (EP+Met) on these aggressive cell lines, optimizing electrical parameters and utilizing key in-vitro cell viability and metabolic assays. Our study integrates high-throughput, label-free quantitative proteomics, cell viability, and ROS analysis alongside advanced computational tools, such as Cytoscape (STRING) protein-protein interaction, GOrilla, and KEGG pathway analysis, to identify and analyze differentially expressed proteins, ensuring robust and reliable insights.
Hydrogen-bonded hexameric cluster of benzyl alcohol in the solid state polymeric organization of p-tert-Butylcalix[5]arene
Creators: name: Kajiki, Yasunori
name: Sekiya, Ryo
name: Takeharu Haino
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: An uncommon hydrogen-bonded hexameric cluster of benzyl alcohol (2) was formed in hydrophobic space in the layered organisation of the one-dimensional polymeric zigzag array of 1 in the solid state. The hexameric cluster adopted a distorted cyclohexane-like (12) O–H⋯O hydrogen bond network. The formation of the hexameric cluster was quite sensitive to a tiny structural difference of guests; phenylethylalcohol (3), phenol (4), benzyl amine (5) and aniline (6) did not form any hexameric cluster. The packing coefficient of 0.53 suggested that the hexameric cluster nicely filled the hydrophobic space, which most likely resulted in the effective van der Waals contacts that stabilised the supramolecular organisation composed of the hexameric cluster and the polymeric array of 1 in the solid state.
White spot syndrome virus (WSSV) recombinant envelope protein VP28 activates shrimp phagocytic activity
Creators: name: Siripong Thitamadee
Publisher: name: Asia-Pacific Journal of Science and Technology
Year: 2022
Subjects: Penaeus vannamei, Cellular immune response, Hemocytes, Phagocytosis, Monomeric recombinant VP28 protein (rVP28)

description: Asia-Pacific Journal of Science and Technology, 27, 2, 7
The validity and reliability of the ‘Cancer Caregiving Tasks, Consequences and Needs Questionnaire’ (CaTCoN)
Creators: name: Lund, Line
name: Ross, Lone
name: Petersen, Morten A.
name: Groenvold, Mogens
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Earth and Environmental Sciences
subject: Engineering

description: Background. Caregivers are often involved in and affected by the patient's disease. The questionnaire ‘Cancer Caregiving Tasks, Consequences and Needs Questionnaire’ (CaTCoN) was developed to measure caregivers’ experiences. The aim of this study is to evaluate the construct validity and reliability of the multi-item scales in the CaTCoN using psychometric analyses as well as tests of convergent and discriminant validity with the existing instruments FAMCARE and Family Inventory of Needs (FIN).Material and methods. Based on theoretical considerations, a subscale structure in the CaTCoN was hypothesized, and the subscales were tested by item-item correlations, followed by factor analysis, calculation of internal consistency by Cronbach's alpha, and multitrait-scaling analysis. Further, theoretically based hypotheses about convergence and divergence between CaTCoN and FAMCARE/FIN (sub)scales were formulated and tested.Results. Analyses were based on 590 caregivers’ responses. Initially, 11 CaTCoN subscales were hypothesized. The item-item correlations and factor analysis lead to some revisions, but the analyses confirmed the hypothesized subscales to a large extent, resulting in nine CaTCoN subscales (Cronbach's alpha range 0.65–0.95). The hypothesized convergent CaTCoN and FAMCARE/FIN subscales correlated 0.59–0.74, and hypothesized divergent CaTCoN and FAMCARE/FIN subscales correlated –0.11–0.25, thus confirming the hypotheses concerning convergent and discriminant validity between CaTCoN and the existing questionnaires FAMCARE and FIN.Conclusion. Taken together the psychometric analyses and tests of convergent and discriminant validity indicate that the validity and reliability of the CaTCoN are satisfactory.
Beyond suspicion? Rethinking feminist hermeneutics after post-critique
Creators: name: Craven, Hannah Margaret
Publisher: name: The University of St Andrews
Year: 2024
Subjects: Hermeneutics
Feminist hermeneutics
Post-critique
Hermeneutics of suspicion
Doctrine of Scripture
Paul Ricoeur
Theological Interpretation of Scripture
Trauma Hermeneutics
Elisabeth Schüssler Fiorenza

description: This thesis defends a faithful form of feminist Biblical interpretation in light of “post-critique.” This is needed as feminist interpretation of the Bible today is dominated by a radical hermeneutics of suspicion which leaves little room for feminist readers who wish to oppose the oppression of women but who also believe that the Bible transmits the Word of God and makes possible an encounter with the divine. Seeking a less one-sided model of critique the thesis turns to a recent development in literary studies known as “post-critique” and explores its viability in relation to feminist Biblical interpretation. The thesis has two parts. Part One first of all offers a survey of the field, locating my approach within it. Chapter 2 highlights the dominance of one-sided suspicious approaches, and then unfolds a counter-model, explaining what is meant by “post-critique” and outlining its foundations in Paul Ricoeur’s hermeneutics. This chapter also provides a defence of a doctrine of Scripture that includes an account of the Bible’s role as mediator of the divine. Building on this general framework, Chapter 3 sets out what “reparative” reading and “second naiveté” might involve in feminist Biblical interpretation. In order to show the utility of this approach, Part Two (chapters 4–6) offers a series of interpretive case-studies on three New Testament texts (Luke 18:1-8; John 20:1-18; John 4:4-42). Each of these chapters engages with a suspicious feminist reading of the pericope, followed by a narrative-theological reading. The thesis concludes by challenging the widespread side-lining of faithful feminist readings of the Bible, both because this is founded on an un-argued-for refusal of theological possibilities, and because in rejecting such readings we forgo a range of significant resources for women’s liberation and flourishing.
Cancer survival in Lithuania after the restoration of independence: Rapid improvements, but persisting major gaps
Creators: name: Brenner, Hermann
name: Gondos, Adam
name: Krilaviciute, Agne
name: Giedre Smailyte
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Science Policy
subject: Cancer
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Ecology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Cell Biology

description: Background. Following restoration of political independence in 1990, Lithuania underwent rapid societal and economic changes. We aimed to assess trends in cancer survival in the first two decades following these changes.Material and methods. We used population-based data from the Lithuanian Cancer Registry and period analysis techniques to examine trends in one-, 2–5- and five-year relative survival between 1995–1999 and 2005–2009 for 24 common cancers in Lithuania.Results. Between 1995–1999 and 2005–2009, five-year relative survival increased significantly for 20 of 24 cancers, and for 10 cancers the increase exceeded 10% units. Five-year relative survival estimates reached 46%, 69% and 91% for colorectal, breast and prostate cancer in 2005–2009, respectively, while patients with testicular cancer, Hodgkin's or non-Hodgkin's lymphoma had a five-year relative survival of 77%, 75% and 50%, respectively.Conclusion. We found a rapid increase in survival for most forms of common cancers in Lithuania between 1995 and 2009. Nevertheless, several cancers with effective therapies exhibit considerable gaps compared with Northern and Western European countries. Despite ongoing rises in survival, mortality declines are not yet manifesting for important common cancers such as breast and colorectal cancer. Rapid incidence rises suggest that increases in survival for prostate and thyroid cancers are massively influenced by early detection-related effects. Improving the availability of effective therapies, and carefully planned early detection programs may help to increase cancer survival in Lithuania in the future.
Prevalence and prognostic impact of comorbidity in soft tissue sarcoma: A population-based cohort study
Creators: name: Maretty-Nielsen, Katja
name: Aggerholm-Pedersen, Ninna
name: Safwat, Akmal
name: Baerentzen, Steen
name: Pedersen, Alma B.
name: Keller, Johnny
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Computational Biology
subject: Cancer
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Physiology
subject: FOS: Biological sciences
subject: Medicine

description: Background. Comorbidity is an important prognostic factor for survival in other cancers, but the importance in soft tissue sarcoma has not yet been clarified. The aims of this study were to examine the prevalence of comorbidity in soft tissue sarcoma patients, and estimate the impact of comorbidity on overall and disease-specific mortality.Material and methods. Overall, 1210 adult patients with soft tissue sarcoma in the extremities or trunk wall were identified through the Aarhus Sarcoma Registry, a validated population-based database. Information on comorbidity was obtained through the National Patient Registry, and a Charlson's Comorbidity score was calculated for each patient. The prevalence of comorbidity was assessed overall, as well as according to age and year of diagnosis. Overall and disease-specific mortality rates according to level of comorbidity were computed. The prognostic value of comorbidity was estimated using crude and adjusted Cox proportional hazard models.Results. The overall prevalence of comorbidity was 25%. The prevalence increased with increasing age, and patients with comorbidity had a larger proportion of adverse prognostic factors when compared to patients without comorbidity. The five-year disease-specific mortality was 26% (95% CI 24–29) for patients without comorbidity, compared to 33% (95% CI 24–42), 41% (95% CI 32–50), and 44% (95% CI 33–55) for patients with mild, moderate, and severe comorbidity, respectively. After adjusting for age, sex, stage, tumor size, depth, grade, surgical margin, radiotherapy, and chemotherapy, comorbidity was independently associated with an increased overall and disease-specific mortality.Conclusion. Patients with comorbidity had significantly increased overall and disease-specific mortality compared to patients without comorbidity, even when adjusting for important prognostic factors including age.
The attitudes towards learning and study habits of Australian medical students
Creators: name: Furness, Taylen
name: Wilson, Carey
name: Ryan, Anna
name: Judd, Terry
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Medical curricula are designed to provide students with strong foundational biomedical knowledge and the opportunity to develop and practice effective, appropriate, and safe clinical skills. However, instruction on optimal study strategies (i.e. “learning how to learn”) is often overlooked in medical programs. In this paper, we explore the attitudes towards learning and study habits of a large cohort of graduate-entry medical students in Australia. Participants in this observational study were invited to complete a questionnaire regarding their attitudes towards study behaviours and strategies, and to complete regular “study diaries” using a custom smartphone application. We collected data for first to fourth-year medical students at various timepoints throughout their academic year. We found that these students generally had a high level of literacy regarding the efficacy of evidence-based study techniques, such as practice testing and active participation, but also tended to favour less effective and more convenient and time-efficient study approaches and activities. Students also reported engaging in distracting off-task activities during approximately 61% of their “private study” sessions; however, due to the self-report nature of the data, this is likely an underestimate. In conclusion, we found that there appears to be a disconnect between medical students’ knowledge and practice of effective study techniques. Given this apparent dissonance—and the significant demands placed on student time and attention—we encourage educators to consider how they might best support students to engage in effective study techniques.
Release of alcohol oxidase 1 (AOX1) from Pichia pastoris during heterologous expression of rice enzymes
Creators: name: Ketudat-Cairns, James R.
Publisher: name: Asia-Pacific Journal of Science and Technology
Year: 2022
Subjects: Alcohol oxidase 1, Anthocyanin, ?-glucosidase 11, Pichia pastoris, Serine carboxypeptidase-like acyltransferase

description: Asia-Pacific Journal of Science and Technology, 27, 2, 10
Condiciones, vicios y propiedades de las señoras mugeres: Digital edition
Creators: name: Leblanc Elina
Publisher: name: Zenodo
Year: 2024
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2024), led by professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Impact of advancing age on treatment and outcomes in anal cancer
Creators: name: Leong, Trevor
name: Foo, Marcus
name: Link, Emma
name: Chu, Julie
name: Lee, Mark T.
name: Sarat Chander
name: Tran, Phillip K.
name: Tomaszewski, Jonathan M.
name: Michael, Michael
name: Heriot, Alexander
name: Ngan, Samuel Y.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Cancer
Biological Sciences
Biotechnology
Cell Biology
Medicine

description: Background. Chemoradiotherapy (CRT) for squamous cell carcinoma of the anus (SCCA) may cause significant toxicity, and concerns exist about its tolerability in the elderly. The authors compared tolerability and outcomes across the age groups following CRT for SCCA.Methods. Single-institution retrospective analysis of patients with localized SCCA treated with CRT. CRT was standardized at 50.4–54 Gy, with concurrent infusional 5-fluorouracil and mitomycin C. Patients were arbitrarily categorized into three groups: Group 1 – age < 50 years; Group 2 – age ≥ 50 and < 70 years; and Group 3 – age ≥ 70 years.Results. Of 284 patients identified, 278 were evaluable. The number of patients in each age group was: Group 1 – 51; Group 2 – 140; and Group 3 – 93. Baseline and treatment characteristics, tumor stage, rates of overall acute toxicity, need for unplanned treatment breaks and chemotherapy delivery were largely similar across the age groups. However, nine patients in Group 3 did not complete CRT, compared with five and none in Groups 1 and 2, respectively (p = 0.006). In addition, five patients in Group 3 had diarrhea requiring treatment break, compared with none in the other two groups (p = 0.004). At a median follow-up 5.3 years, there was no significant difference in overall survival (p = 0.11), disease-free survival (p = 0.22) or local-recurrence free survival (p = 0.34), across the three age groups.Conclusions. CRT is safe and tolerable in the elderly age group, and provides equivalent disease control rates compared with the younger age group. Age alone should therefore not preclude aggressive curative treatment.
Condiciones, vicios y propiedades de las señoras mugeres: Digital edition
Creators: name: Leblanc Elina
Publisher: name: Zenodo
Year: 2021
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2022), led by the professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
The validity and reliability of the ‘Cancer Caregiving Tasks, Consequences and Needs Questionnaire’ (CaTCoN)
Creators: name: Lund, Line
name: Ross, Lone
name: Petersen, Morten A.
name: Groenvold, Mogens
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Earth and Environmental Sciences
subject: Engineering

description: Background. Caregivers are often involved in and affected by the patient's disease. The questionnaire ‘Cancer Caregiving Tasks, Consequences and Needs Questionnaire’ (CaTCoN) was developed to measure caregivers’ experiences. The aim of this study is to evaluate the construct validity and reliability of the multi-item scales in the CaTCoN using psychometric analyses as well as tests of convergent and discriminant validity with the existing instruments FAMCARE and Family Inventory of Needs (FIN).Material and methods. Based on theoretical considerations, a subscale structure in the CaTCoN was hypothesized, and the subscales were tested by item-item correlations, followed by factor analysis, calculation of internal consistency by Cronbach's alpha, and multitrait-scaling analysis. Further, theoretically based hypotheses about convergence and divergence between CaTCoN and FAMCARE/FIN (sub)scales were formulated and tested.Results. Analyses were based on 590 caregivers’ responses. Initially, 11 CaTCoN subscales were hypothesized. The item-item correlations and factor analysis lead to some revisions, but the analyses confirmed the hypothesized subscales to a large extent, resulting in nine CaTCoN subscales (Cronbach's alpha range 0.65–0.95). The hypothesized convergent CaTCoN and FAMCARE/FIN subscales correlated 0.59–0.74, and hypothesized divergent CaTCoN and FAMCARE/FIN subscales correlated –0.11–0.25, thus confirming the hypotheses concerning convergent and discriminant validity between CaTCoN and the existing questionnaires FAMCARE and FIN.Conclusion. Taken together the psychometric analyses and tests of convergent and discriminant validity indicate that the validity and reliability of the CaTCoN are satisfactory.
Eye; includes: Some Pathological Conditions of the Eye; Corneal Grafting and the Eye Bank; Cataract: Shadows That Need Not Be; Shedding New Light on Cataract Surgery; Cataracts, Development, Diagnosis, Management; Buckling Operation for Retinal Detachment (Medical illustrations)
Creators: name: Francone, Clarice Ashworth
Publisher: name: Oregon Health & Science University
Year: 0
Subjects: Medical Illustration
Eye
Anatomy, Cross-Sectional
Corneal Transplantation
Eye Diseases
Equipment and Supplies

description: Sixteen pencil sketches, including exterior sketches of the eye, corneal transplants, the interior of the eye and instruments used to hold the eyes open during medical procedures.
The predictive value of KRAS, NRAS, BRAF, PIK3CA and PTEN for anti-EGFR treatment in metastatic colorectal cancer: A systematic review and meta-analysis
Creators: name: Therkildsen, Christina
name: Bergmann, Troels K.
name: Ladelund, Steen
name: Mef Nilbert
name: Henrichsen-Schnack, Tine
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: Cancer
subject: Chemistry
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biophysics

description: Background. In metastatic colorectal cancer, mutation testing for KRAS exon 2 is widely implemented to select patients with wild-type tumors for treatment with the monocloncal anti-EGFR antibodies cetuximab and panitumumab. The added predictive value of additional biomarkers in the RAS-RAF-MAPK and PI3K-AKT-mTOR pathways in colorectal cancer is uncertain, which led us to systematically review the impact of alterations in KRAS (outside of exon 2), NRAS, BRAF, PIK3CA and PTEN in relation to the clinical benefit from anti-EGFR treatment.Methods. In total, 22 studies that include 2395 patients formed the basis for a meta-analysis on alterations in KRAS exons 3 and 4, NRAS, BRAF, and PIK3CA and PTEN and outcome of anti-EGFR treatment. Odds ratios for objective response rate (ORR) and hazard ratios (HR) for progression-free survival (PFS) and overall survival (OS) were calculated.Results. Mutations in KRAS exons 3 and 4, BRAF, PIK3CA and non-functional PTEN (mutations or loss of protein expression) significantly predicted poor ORR (OR = 0.26, OR = 0.29, OR = 0.39, and OR = 0.41, respectively). Significantly shorter PFS applied to mutations in KRAS exons 3 and 4 (HR = 2.19), NRAS (HR = 2.30) and BRAF (HR = 2.95) and non-functional PTEN (HR = 1.88). Significantly shorter OS applied to mutations in KRAS exons 3 and 4 (HR = 1.78), NRAS (HR = 1.85), BRAF (HR = 2.52), PIK3CA (HR = 1.43) and alterations in PTEN (HR = 2.09).Conclusions. Meta-analysis suggests that mutations in KRAS exons 3 and 4, NRAS, BRAF and PIK3CA and non-functional PTEN predict resistance to anti-EGFR therapies and demonstrates that biomarker analysis beyond KRAS exon 2 should be implemented for prediction of clinical benefit from anti-EGFR antibodies in metastatic colorectal cancer.
Differences in respiratory-induced pancreatic tumor motion between 4D treatment planning CT and daily cone beam CT, measured using intratumoral fiducials
Creators: name: Fockens, Paul
name: Lens, Eelco
name: Horst, Astrid Van Der
name: Kroon, Petra S.
name: Jeanin E. Van Hooft
name: Fajardo, Raquel Dávila
name: Geertjan Van Tienhoven
name: Bel, Arjan
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Cancer
subject: Biological Sciences
subject: Physiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Physics
subject: Engineering
subject: Biochemistry

description: Background. In radiotherapy, the magnitude of respiratory-induced tumor motion is often measured using a single four-dimensional computed tomography (4DCT). This magnitude is required to determine the internal target volume. The aim of this study was to compare the magnitude of respiratory-induced motion of pancreatic tumors on a single 4DCT with the motion on daily cone beam CT (CBCT) scans during a 3–5-week fractionated radiotherapy scheme. In addition, we investigated changes in the respiratory motion during the treatment course.Material and methods. The mean peak-to-peak motion (i.e. magnitude of motion) of pancreatic tumors was measured for 18 patients using intratumoral gold fiducials visible on CBCT scans made prior to each treatment fraction (10–27 CBCTs per patient; 401 CBCTs in total). For each patient, these magnitudes were compared to the magnitude measured on 4DCT. Possible time trends were investigated by applying linear fits to the tumor motion determined from daily CBCTs as a function of treatment day.Results. We found a significant (p ≤ 0.01) difference between motion magnitude on 4DCT and on CBCT in superior-inferior, anterior-posterior and left-right direction, in 13, 9 and 12 of 18 patients, respectively. In the anterior- posterior and left-right direction no fractions had a difference ≥ 5 mm. In the superior-inferior direction the difference was ≥ 5 mm for 17% of the 401 fractions. In this direction, a significant (p ≤ 0.05) time trend in tumor motion was observed in 4 of 18 patients, but all trends were small (− 0.17–0.10 mm/day) and did not explain the large differences in motion magnitude between 4DCT and CBCT.Conclusion. A single measurement of the respiratory-induced motion magnitude of pancreatic tumors using 4DCT is often not representative for the magnitude during daily treatment over a 3–5-week radiotherapy scheme. For this patient group it may be beneficial to introduce breath-hold to eliminate respiratory-induced tumor motion.
Condiciones, vicios y propiedades de las señoras mugeres: Digital edition
Creators: name: Leblanc Elina
Publisher: name: Zenodo
Year: 2022
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2024), led by the professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Life cycle assessment of perovskite solar cell based onrapid convective deposition at electron transport layer
Creators: name: Viganda Varabuntoonvit
Publisher: name: Asia-Pacific Journal of Science and Technology
Year: 2022
Subjects: Perovskite solar cells,Rapid Convective Deposition,Crystalline silicon solar cells,Lifecycle assessment, Photovoltaic technologies, Environmental analysis, Greenhouse gas emission, Energy payback time

description: Asia-Pacific Journal of Science and Technology, 27, 2, 12
Prescribing and evaluating target dose in dose-painting treatment plans
Creators: name: Specht, Lena
name: Aznar, Marianne C.
name: Rasmussen, Jacob H.
name: Bentzen, Søren M.
name: Vogelius, Ivan R.
name: Håkansson, Katrin
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Hematology
subject: Cancer
subject: Biological Sciences
subject: Chemistry
subject: Pharmacology
subject: Physiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Medicine
subject: Physics

description: Background. Assessment of target dose conformity in multi-dose-level treatment plans is challenging due to inevitable over/underdosage at the border zone between dose levels. Here, we evaluate different target dose prescription planning aims and approaches to evaluate the relative merit of such plans. A quality volume histogram (QVH) tool for history-based evaluation is proposed.Material and methods. Twenty head and neck cancer dose-painting plans with five prescription levels were evaluated, as well as clinically delivered simultaneous integrated boost (SIB) plans from 2010 and 2012. The QVH tool was used for target dose comparison between groups of plans, and to identify and improve a suboptimal dose-painting plan.Results. Comparison of 2010 and 2012 treatment plans with the QVH tool demonstrated that 2012 plans have decreased underdosed volume at the expense of increased overdosed volume relative to the 2010 plans. This shift had not been detected previously. One suboptimal dose-painting plan was compared to the ‘normal zone’ of the QVH tool and could be improved by re-optimization.Conclusion. The QVH tool provides a method to assess target dose conformity in dose-painting and multi-dose-level plans. The tool can be useful for quality assurance of multi-center trials, and for visualizing the development of treatment planning in routine clinical practice.
Kinetic model of synthetic diesel production from stearic acid using MATLAB
Creators: name: Penjit Srinophakun
Publisher: name: Asia-Pacific Journal of Science and Technology
Year: 2022
Subjects: Green diesel, Hydrodeoxygenation, Kinetic model, MATLAB, Stearic acid, Synthetic diesel

description: Asia-Pacific Journal of Science and Technology, 27, 2, 7
Aus dem Auge, aus dem Sinn? Die italienischen Rückführungszentren in Albanien als Instrument der Externalisierung der Migrationspolitik
Creators: name: Schönthaler, Sophia
Publisher: name: Eurac Research
Year: 2024

description: Mit einigen Monaten Verspätung wurden vor wenigen Tagen, im Oktober 2024, die ersten Asylsuchenden von Italien in das Rückführungszentrum nach Albanien gebracht. Laut Plan sollen zwei Zentren in Albanien entstehen; Platz soll für „illegale“ Migranten aus „sicheren“ Herkunftsländern sein. Der Zustand in den Zentren selbst ähnelt einem Gefängnis.
Vanishing bile duct-like syndrome in a patient with Hodgkin lymphoma – pathological development and restitution
Creators: name: Nilsson, Thomas
name: Nordgren, Hans
name: Alkwin Wanders
name: Molin, Daniel
name: Hallén, Karin
name: Sangfelt, Per
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: 60506 Virology
subject: FOS: Biological sciences
subject: Plant Biology
subject: Hematology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Cancer
subject: Developmental Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Genetics
subject: Medicine
subject: Physics
subject: Engineering

description: Vanishing bile duct-like syndrome in a patient with Hodgkin lymphoma – pathological development and restitution