cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Variants in CUL4B are Associated with Cerebral Malformations
Creators: name: Philips, Anju K.
name: Voesenek, Krysta
name: Willemsen, Michèl A.A.P.
name: Obersztyn, Ewa
name: Xiong, Yue
name: de Vries, Bert B.A.
name: Odent, Sylvie
name: Kleefstra, Tjitske
name: Lebrun, Nicolas
name: van Bokhoven, Hans
name: Charzewska, Agnieszka
name: Chelly, Jamel
name: Fischer, Ute
name: Ropers, Hans-Hilger
name: Nillesen, Willy M.
name: Vigneron, Jacqueline
name: Baumer, Alessandra
name: Lenart, Jacek
name: Barkovich, A. James
name: Brunner, Han G.
name: Rauch, Anita
name: Kalscheuer, Vera M.
name: Poirier, Karine
name: Yntema, Helger G.
name: Amram, Daniel
name: de Brouwer, Arjan P.M.
name: Nawara, Magdalena
name: Raymond, F. Lucy
name: Järvelä, Irma
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Variants in cullin 4B (CUL4B) are a known cause of syndromic X-linked intellectual disability. Here, we describe an additional 25 patients from 11 families with variants in CUL4B. We identified nine different novel variants in these families and confirmed the pathogenicity of all nontruncating variants. Neuroimaging data, available for 15 patients, showed the presence of cerebral malformations in ten patients. The cerebral anomalies comprised malformations of cortical development (MCD), ventriculomegaly, and diminished white matter volume. The phenotypic heterogeneity of the cerebral malformations might result from the involvement of CUL-4B in various cellular pathways essential for normal brain development. Accordingly, we show that CUL-4B interacts with WDR62, a protein in which variants were previously identified in patients with microcephaly and a wide range of MCD. This interaction might contribute to the development of cerebral malformations in patients with variants in CUL4B.
Supplementary Information from Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMTs inhibitors
Creators: name: Halby, Ludovic
name: Marechal, Nils
name: Pechalrieu, Dany
name: Cura, Vincent
name: Don-Marc Franchini
name: Faux, Céline
name: Fréderic Alby
name: Troffer-Charlier, Nathalie
name: Srikanth Kudithipudi
name: Jeltsch, Albert
name: Aouadi, Wahiba
name: Decroly, Etienne
name: Guillemot, Jean-Claude
name: Page, Patrick
name: Ferroud, Clotilde
name: Bonnefond, Luc
name: Guianvarc'h, Dominique
name: Cavarelli, Jean
name: Arimondo, Paola B.
Publisher: name: The Royal Society
Year: 2018
Subjects: Biochemistry

description: NMR attribution, complementary Materials & Methods and Biological results
Supplement from New chemical tools for probing activity and inhibition of the NAD+-dependent lysine deacylase sirtuin 2.
Creators: name: Swyter, Sören
name: Schiedel, Matthias
name: Monaldi, Daria
name: Szunyogh, Sándor
name: Lehotzky, Attila
name: Rumpf, Tobias
name: Ovádi, Judit
name: Sippl, Wolfgang
name: Jung, Manfred
Publisher: name: The Royal Society
Year: 2018
Subjects: Biochemistry

description: Experimental procedures, additional figures, codes
The inflammation highway: metabolism accelerates inflammatory traffic in obesity
Creators: name: Johnson, Amy R.
name: Makowski, Liza
name: Justin Milner, J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: As humans evolved, perhaps the two strongest selection determinants of survival were a robust immune response able to clear bacterial, viral, and parasitic infection and an ability to efficiently store nutrients to survive times when food sources were scarce. These traits are not mutually exclusive. It is now apparent that critical proteins necessary for regulating energy metabolism such as peroxisome proliferator-activated receptors (PPARs), Toll-like receptors (TLRs), and fatty acid-binding proteins (FABPs) also act as links between nutrient metabolism and inflammatory pathway activation in immune cells. Obesity in humans is a symptom of energy imbalance: the scale has been tipped such that energy intake exceeds energy output and may be a result, in part, of evolutionary selection toward a phenotype characterized by efficient energy storage. As discussed in this review, obesity is a state of low-grade, chronic inflammation that promotes the development of insulin resistance and diabetes. Ironically, the formation of systemic and/or local, tissue-specific insulin resistance upon inflammatory cell activation may actually be a protective mechanism that co-evolved to repartition energy sources within the body during times of stress during infection. However, the point has been reached where a once beneficial adaptive trait has become detrimental to the health of the individual and an immense public health and economic burden. This article reviews the complex relationship between obesity, insulin resistance/diabetes, and inflammation, and while the liver, brain, pancreas, muscle, and other tissues are relevant, we focus specifically on how the obese adipose microenvironment can promote immune cell influx and sustain damaging inflammation that can lead to the onset of insulin resistance and diabetes. Finally, we address how substrate metabolism may regulate the immune response and discuss how fuel uptake and metabolism may be a targetable approach to limit or abrogate obesity-induced inflammation.
Optimizing Quantum Adiabatic Algorithm
Creators: name: Hu, Hongye
name: Wu, Biao
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In quantum adiabatic algorithm, as the adiabatic parameter $s(t)$ changes slowly from zero to one with finite rate, a transition to excited states inevitably occurs and this induces an intrinsic computational error. We show that this computational error depends not only on the total computation time $T$ but also on the time derivatives of the adiabatic parameter $s(t)$ at the beginning and the end of evolution. Previous work (Phys. Rev. A \textbf{82}, 052305) also suggested this result. With six typical paths, we systematically demonstrate how to optimally design an adiabatic path to reduce the computational errors. Our method has a clear physical picture and also explains the pattern of computational error. In this paper we focus on quantum adiabatic search algorithm although our results are general.
description: 8 pages, 9 figures
(400681) Beatrice Lyell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Pyroptotic cell death defends against intracellular pathogens
Creators: name: Miao, Edward A.
name: Jorgensen, Ine
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Inflammatory caspases play a central role in innate immunity by responding to cytosolic signals and initiating a twofold response. First, caspase-1 induces the activation and secretion of the two prominent pro-inflammatory cytokines, interleukin-1β (IL-1β) and IL-18. Second, either caspase-1 or caspase-11 can trigger a form of lytic, programmed cell death called pyroptosis. Pyroptosis operates to remove the replication niche of intracellular pathogens, making them susceptible to phagocytosis and killing by a secondary phagocyte. However, aberrant, systemic activation of pyroptosis in vivo may contribute to sepsis. Emphasizing the efficiency of inflammasome detection of microbial infections, many pathogens have evolved to avoid or subvert pyroptosis. This review focuses on molecular and morphological characteristics of pyroptosis and the individual inflammasomes and their contribution to defense against infection in mice and humans.
Detecting itinerant single microwave photons
Creators: name: Sathyamoorthy, Sankar Raman
name: Stace, Thomas M.
name: Johansson, Göran
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Single photon detectors are fundamental tools of investigation in quantum optics and play a central role in measurement theory and quantum informatics. Photodetectors based on different technologies exist at optical frequencies and much effort is currently being spent on pushing their efficiencies to meet the demands coming from the quantum computing and quantum communication proposals. In the microwave regime however, a single photon detector has remained elusive although several theoretical proposals have been put forth. In this article, we review these recent proposals, especially focusing on non-destructive detectors of propagating microwave photons. These detection schemes using superconducting artificial atoms can reach detection efficiencies of 90\% with existing technologies and are ripe for experimental investigations.
description: 11 pages, 8 figures
Utility of Thrombin Generation Assays Towards Measuring the Anticoagulant Effects of Direct Oral Anticoagulants and Anticoagulation Reversal
Creators: name: Shaw, Joseph R.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2023
Subjects: Thrombin Generation
Direct Thrombin Inhibitors
Direct Factor Xa Inhibitors
Anticoagulation Reversal
Hemostasis

description: Direct factor Xa inhibitors (FXaI) account for most oral anticoagulant use. FXaI-associated bleeding events are common and are associated with substantial morbidity and mortality. Nonspecific hemostatic therapies such as prothrombin complex concentrates (PCC) are often administered for FXaI-associated bleeding. The mechanism by which these agents improve hemostasis in the setting of direct oral anticoagulation is unclear. Thrombin generation assays may effectively measure the effect of anticoagulation reversal among FXaI-treated patients when bleeding cessation would otherwise be challenging to measure. To build a research program on the utility of thrombin generation assays to measure both the impact of direct oral anticoagulation and anticoagulation reversal, we completed a review of the literature with narrative synthesis and carried out a pilot study to determine the feasibility of a full scale prospective observational study of TGA responses among patients receiving PCC for FXaI-associated major bleeding or needing urgent surgery.
Multiband electronic characterization of the complex intermetallic cage system Y$_{1-x}$Gd$_x$Co$_{2}$Zn$_{20}$
Creators: name: Cabrera-Baez, M.
name: Naranjo-Uribe, A.
name: Osorio-Guillén, J. M.
name: Rettori, C.
name: Avila, M. A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: A detailed microscopic and quantitative description of the electronic and magnetic properties of Gd$^{3+}$-doped YCo$_{2}$Zn$_{20}$ single crystals (Y$_{1-x}$Gd$_{x}$Co$_{2}$Zn$_{20}$: (0.002 $\lesssim x \leq $ 1.00) is reported through a combination of temperature-dependent electron spin resonance (ESR), heat capacity and $dc$ magnetic susceptibility experiments, plus first-principles density functional theory (DFT) calculations. The ESR results indicate that this system features an \emph{exchange bottleneck} scenario wherein various channels for the spin-lattice relaxation mechanism of the Gd$^{3+}$ ions can be identified via exchange interactions with different types of conduction electrons at the Fermi level. Quantitative support from the other techniques allow to extract the exchange interaction parameters between the localized magnetic moments of the Gd$^{3+}$ ions and the different types of conduction electrons present at the Fermi level ($J_{fs}$, $J_{fp}$ and $J_{fd}$). Despite the complexity of the crystal structure, our combination of experimental and electronic structure data establish GdCo$_{2}$Zn$_{20}$ as a model RKKY system by predicting a Curie-Weiss temperature $θ_{C} = -1.2(2)$~K directly from microscopic parameters, in very good agreement with the bulk value from magnetization data. The successful microscopic understanding of the electronic structure and behavior for the two end compounds YCo$_{2}$Zn$_{20}$ and GdCo$_{2}$Zn$_{20}$ means they can be used as references to help describe the more complex electronic properties of related materials.
description: Phys. Rev. B (accepted)
ONZIN deficiency attenuates contact hypersensitivity responses in mice
Creators: name: Nguyen, MyTrang
name: Jania, Leigh A
name: Kovarova, Martina
name: Koller, Beverly H
name: Ledford, Julie G
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: ONZIN is abundantly expressed in immune cells of both the myeloid and lymphoid lineage. Expression by lymphoid cells has been reported to further increase after cutaneous exposure of mice to antigens and haptens capable of inducing contact hypersensitivity, suggesting that ONZIN plays a critical role in this response. Here, we report that indeed ONZIN-deficient mice develop attenuated CHS to a number of different haptens. Dampened CHS responses correlated with a significant reduction in pro-inflammatory IL-6 at the challenge site in ONZIN-deficient animals compared to wild type controls. Together the study of these animals indicates that loss of ONZIN impacts the effector phase of the CHS response through the regulation of pro-inflammatory factors.
Presentably symmetric monoidal infinity-categories are represented by symmetric monoidal model categories
Creators: name: Nikolaus, Thomas
name: Sagave, Steffen
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Topology (math.AT)
subject: Category Theory (math.CT)
subject: FOS: Mathematics
subject: 55U35

description: We prove the theorem stated in the title. More precisely, we show the stronger statement that every symmetric monoidal left adjoint functor between presentably symmetric monoidal infinity-categories is represented by a strong symmetric monoidal left Quillen functor between simplicial, combinatorial and left proper symmetric monoidal model categories.
description: v3: 17 pages, references updated and exposition improved, accepted for publication in Algebraic and Geometric Topology
Pandemic preparedness: why humanities and social sciences matter.
Creators: name: Frampton, Sally
name: Orievulu, Kingsley
name: Matthews, Philippa C
name: Giubilini, Alberto
name: Hordern, Joshua
name: Burns, Lizzie
name: Elias, Sean
name: Friederich, Ethan
name: Majozi, Nomathamsanqa
name: Martin, Sam
name: Stevenson, Austin
name: Vanderslott, Samantha
name: Seeley, Janet
Publisher: name: The Francis Crick Institute
Year: 2024
Subjects: classificationCode: Infectious Disease
subject: Infectious Disease
classificationCode: Immunology
subject: Immunology
subject: FOS: Clinical medicine
classificationCode: Genetics & Genomics
subject: Genetics & Genomics

description: Whilst many lessons were learned from the COVID-19 pandemic, ongoing reflection is needed to develop and maintain preparedness for future outbreaks. Within the field of infectious disease and public health there remain silos and hierarchies in interdisciplinary work, with the risk that humanities and social sciences remain on the epistemological peripheries. However, these disciplines offer insights, expertise and tools that contribute to understanding responses to disease and uptake of interventions for prevention and treatment. In this Perspective, using examples from our own cross-disciplinary research and engagement programme on vaccine hesitancy in South Africa and the United Kingdom (UK), we propose closer integration of expertise, research and methods from humanities and social sciences into pandemic preparedness.
Supplement from New chemical tools for probing activity and inhibition of the NAD+-dependent lysine deacylase sirtuin 2
Creators: name: Swyter, Sören
name: Schiedel, Matthias
name: Monaldi, Daria
name: Szunyogh, Sándor
name: Lehotzky, Attila
name: Rumpf, Tobias
name: Ovádi, Judit
name: Sippl, Wolfgang
name: Jung, Manfred
Publisher: name: The Royal Society
Year: 2018
Subjects: Biochemistry

description: Experimental procedures, additional figures, codes
Non-fixation for Biased Activated Random Walks
Creators: name: Rolla, Leonardo T.
name: Tournier, Laurent
Publisher: name: arXiv
Year: 2015
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: We prove that the model of Activated Random Walks on Z^d with biased jump distribution does not fixate for any positive density, if the sleep rate is small enough, as well as for any finite sleep rate, if the density is close enough to 1. The proof uses a new criterion for non-fixation. We provide a pathwise construction of the process, of independent interest, used in the proof of this non-fixation criterion.
Supplementary Material: Desferrioxamine biosynthesis: Diverse hydroxamate assembly by substrate-tolerant acyl transferase DesC.
Creators: name: Ronan, Jade L.
name: Kadi, Nadia
name: McMahon, Stephen A.
name: Naismith, James H.
name: Alkhalaf, Lona M.
name: Challis, Gregory L.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Structural Biology
subject: 60113 Synthetic Biology
subject: FOS: Biological sciences

description: Experimental procedures and supporting data
(400676) Grace Lyell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Effective Interactions in Active Brownian Suspensions
Creators: name: Farage, T. F. F.
name: Krinninger, P.
name: Brader, J. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Physical sciences

description: Active colloids exhibit persistent motion, which can lead to motility-induced phase separation (MIPS). However, there currently exists no microscopic theory to account for this phenomenon. We report a first-principles theory, free of fit parameters, for active spherical colloids, which shows explicitly how an effective many-body interaction potential is generated by activity and how this can rationalize MIPS. For a passively repulsive system the theory predicts phase separation and pair correlations in quantitative agreement with simulation. For an attractive system the theory shows that phase separation becomes suppressed by moderate activity, consistent with recent experiments and simulations, and suggests a mechanism for reentrant cluster formation at high activity.
description: 10 pages, 3 figures
The effects of building-related factors on classroom relative humidity among North Carolina schools participating in the ‘Free to Breathe, Free to Teach’ study
Creators: name: Marshall, S. W.
name: Lipton, D. M.
name: LoFrese, T.
name: Richardson, D. B.
name: Angelon-Gaetz, K. A.
name: Lamb, B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Both high and low indoor relative humidity (RH) directly impact indoor air quality (IAQ), an important school health concern. Prior school studies reported a high prevalence of mold, roaches, and water damage; however, few examined associations between modifiable classroom factors and RH, a quantitative indicator of dampness. We recorded RH longitudinally in 134 North Carolina classrooms (n= 9066 classroom-days) to quantify the relationships between modifiable classroom factors and average daily RH below, within, or above levels recommended to improve school IAQ (30–50% or 30–60% RH). The odds of having high RH (>60%) were 5.8 (95% Confidence Interval (CI): 2.9, 11.3) times higher in classrooms with annual compared to quarterly heating, ventilating, and air conditioning (HVAC) system maintenance, and 2.5 (95% CI: 1.5, 4.2) times higher in classrooms with HVAC economizers compared to those without economizers. Classrooms with direct expansion split systems compared to chilled water systems had 2.7 (95% CI: 1.7, 4.4) times higher odds of low RH (<30%). When unoccupied, classrooms with thermostat setbacks had 3.7 (95% CI: 1.7, 8.3) times the odds of high RH (>60%) of those without setbacks. This research suggests actionable decision points for school design and maintenance to prevent high or low classroom RH.
(400677) James Carmichael Lyell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Floer Simple Manifolds and L-Space Intervals
Creators: name: Rasmussen, Jacob
name: Rasmussen, Sarah Dean
Publisher: name: arXiv
Year: 2015
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 57M27

description: An oriented three-manifold with torus boundary admits either no L-space Dehn filling, a unique L-space filling, or an interval of L-space fillings. In the latter case, which we call "Floer simple," we construct an invariant which computes the interval of L-space filling slopes from the Turaev torsion and a given slope from the interval's interior. As applications, we give a new proof of the classification of Seifert fibered L-spaces over $S^2$, and prove a special case of a conjecture of Boyer and Clay about L-spaces formed by gluing three-manifolds along a torus.
description: 50 pages, 2 figures
Frauen im Spannungsfeld von Weiblichkeit und rhetorischer Kompetenz; Stand: 13.09.2022
Creators: name: Heinemann, Sarah
Publisher: name: RWTH Aachen University
Year: 2022
Subjects: subject: FOS: Social sciences
subject: FOS: Social sciences
subject: Gender

description: blog interdisziplinäre geschlechterforschung; Duisburg-Essen : DuEPublico 4 Seiten (2022). doi:10.17185/GENDER/20220913
description: Published by DuEPublico, Duisburg-Essen
Supplementary Material: Desferrioxamine biosynthesis: Diverse hydroxamate assembly by substrate-tolerant acyl transferase DesC
Creators: name: Ronan, Jade L.
name: Kadi, Nadia
name: McMahon, Stephen A.
name: Naismith, James H.
name: Alkhalaf, Lona M.
name: Challis, Gregory L.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Structural Biology
subject: 60113 Synthetic Biology
subject: FOS: Biological sciences

description: Experimental procedures and supporting data
Dyadic Interaction: Greater than the Sum of its Parts?
Creators: name: Cohn, Jeffrey F.
name: Moore, Ginger A.
name: Allen, Nicholas B.
name: Propper, Cathi B.
name: Lewinsohn, Peter M.
name: Bass, Anneliese J.
name: Powers, Christopher J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The study of dyadic interaction plays a major role in infancy research. To advance conceptually-informed measurement of dyadic interaction and integration across studies, we examined factor structure of individual parents’ and infants’ measures and dyadic measures from face-to-face interactions in two samples of 6-mo-old infants and their parents: mothers from a demographically heterogeneous sample (N = 164) and mothers and fathers (N = 156) from a Caucasian middle-class sample. Results suggested: a) individual and dyadic measures, and parents’ and infants’ behaviors contribute independent information, b) measures of both valence and process are needed, c) there are context-general and context-specific qualities, and d) structure of dyadic interaction is more similar among mother-infant dyads from independent samples than between mother- and father-infant dyads within the same sample. Future research should use multiple measures incorporating valence, temporal processes, contextual influences, and behaviors of individual partners along with dyadic measures to adequately assess the quality of dyadic interaction.
Supplemental Information: Rapid recalibration of speech perception after experiencing the McGurk illusion.
Creators: name: Lüttke, Claudia S.
name: Pérez-Bellido, Alexis
name: Lange, Floris P. De
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Neuroscience
subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology

description: Supplemental results, figure, table
Bidirectional Associations Among Sensitive Parenting, Language Development, and Social Competence
Creators: name: Barnett, Melissa A.
name: Deng, Min
name: Cox, Martha
name: Gustafsson, Hanna
name: Mills-Koonce, W. Roger
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Rapid changes in language skills and social competence, both of which are linked to sensitive parenting, characterize early childhood. The present study examines bidirectional associations among mothers’ sensitive parenting and children’s language skills and social competence from 24 to 36 months in a community sample of 174 families. In addition, this study examines how these developmental pathways vary by child sex. Findings indicate stability across time in sensitive parenting, expressive language skills, and social competence, as well as positive main effects of sensitive parenting on expressive and receptive language skills for girls and boys. We find mixed evidence over time of reciprocal links between social competence and sensitive parenting. Further, boys’ receptive language skills at 24 months uniquely contribute to increases in mothers’ observed sensitive parenting from 24 to 36 months. These findings highlight the utility of applying transactional frameworks to the study of sex-based differences in early developmental processes.
PROMOTING SUPPORTIVE PARENTING IN NEW MOTHERS WITH SUBSTANCE-USE PROBLEMS: A PILOT RANDOMIZED TRIAL OF RESIDENTIAL TREATMENT PLUS AN ATTACHMENT-BASED PARENTING PROGRAM: Residential Treatment and Attachment
Creators: name: Berlin, Lisa J.
name: Shanahan, Meghan
name: Appleyard Carmody, Karen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: This pilot randomized trial tested the feasibility and efficacy of supplementing residential substance-abuse treatment for new mothers with a brief, yet rigorous, attachment-based parenting program. Twenty-one predominantly (86%) White mothers and their infants living together in residential substance-abuse treatment were randomly assigned to the program (n = 11) or control (n = 10) group. Program mothers received 10 home-based sessions of Dozier’s Attachment and Biobehavioral Catch-up (ABC) intervention. Postintervention observations revealed more supportive parenting behaviors among the randomly assigned ABC mothers.
(Pure) transcendence bases in $ϕ$-deformed shuffle bialgebras
Creators: name: Bui, Van Chiên
name: Duchamp, Gérard H. E.
name: Ngô, Quoc Hoan
name: Minh, Vincel Hoang Ngoc
name: Tollu, Christophe
Publisher: name: arXiv
Year: 2015
Subjects: subject: Symbolic Computation (cs.SC)
subject: Mathematical Physics (math-ph)
subject: Combinatorics (math.CO)
subject: Group Theory (math.GR)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: Computations with integro-differential operators are often carried out in an associative algebra with unit, and they are essentially non-commutative computations. By adjoining a cocommutative co-product, one can have those operators perform act on a bialgebra isomorphic to an enveloping algebra. That gives an adequate framework for a computer-algebra implementation via monoidal factorization, (pure) transcendence bases and Poincaré--Birkhoff--Witt bases. In this paper, we systematically study these deformations, obtaining necessary and sufficient conditions for the operators to exist, and we give the most general cocommutative deformations of the shuffle co-product and an effective construction of pairs of bases in duality. The paper ends by the combinatorial setting of local systems of coordinates on the group of group-like series.
description: The present work is part of a series of papers devoted to the study of the renormalization of divergent polyzetas (at positive and at non-positive indices) via the factorization of the non commutative generating series of polylogarithms and of harmonic sums and via the effective construction of pairs of dual bases in duality in $\phi$ deformed shuffle algebras. It is a sequel to [3] and its content was presented in several seminars and meetings, including the 74th S\'eminaire Lotharingien de Combinatoire
Genetics of Serum Resistance in Neisseria gonorrhoeae: The sac-1 Genetic Locus
Creators: name: Lee, Terrence
name: Cannon, Janne
name: Guymon, Lawrence
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1981

description: A genetic locus affecting susceptibility to the bactericidal activity of normal human serum has been designated sac-1. This locus was shown to be closely linked to, but not identical with, a second locus (designated nmp-2) that affects protein 1 of the outer membrane. The sac-1 locus could be linked to known antibiotic resistance markers on the gonococcal chromosome by genetic transformation.
(400679) Christina C Lyell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Determinants of Barley Output Supply Response in Ethiopia: Application of Ardl Bound Cointegration Approach
Creators: name: Tirfi, Abera Gayesa
name: Tirfi, Abera Gayesa
Publisher: name: Unknown
Year: 2022
Subjects: subject: Production Economics
subject: Productivity Analysis
subject: Changing climate
subject: Supply response
subject: Barley output
subject: ARDL model

description: This study investigated barley output supply response determinant factors in Ethiopia. An ARDL bound test approach was employed as method using secondary data from 1981-2020. The study demonstrated that barley output supply was affected positively and significantly by zero-order lagged seasonal rainfall and crop growing period temperature. The study supports the findings of researchers who reported that warming temperature followed by an increase in the amount of rainfall had a positive impact on barley output supply. The positive impact of temperature was induced because of a rise in the ocean and earth’s surface average temperature, causing more evaporation that increases overall rainfall while reaching over the highland areas. Studies confirm that ENSO and moist winds coming from the Atlantic and Indian Oceans influence the occurrence of rainfall in the western, southeastern, central, and northern highlands of Ethiopia. The study further exhibited that CSMRR and CGPMT had a positive effect on barley output both in the long-run and short-run, implying that climate parameters have minimal effect on barley production. Nonclimatic variables demonstrated that both lagged and current year’s producer prices had a positively significant effect on barley output supply in both the long-run and short-run, implying that barley output supply is highly responsive to any price incentive strategies announced before re-allocation of the area towards barley cultivation. Conversely, the study explored that use of fertilizer in first-order lag had negatively significant impact on barley output supply in both seasons; implying that increased use of fertilizer in lagged period may reduce barley output as a result of inappropriate fertilizers application by farmers. The results generated by this study are useful addendum to the repository of knowledge on elasticity of crop supply at an aggregate level, which can be used in designing strategies and measures for mitigation and adaptation of climate change.
Supplemental Information: Rapid recalibration of speech perception after experiencing the McGurk illusion
Creators: name: Lüttke, Claudia S.
name: Pérez-Bellido, Alexis
name: Lange, Floris P. De
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Neuroscience
subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology

description: Supplemental results, figure, table
Monoclonal antibodies against Neisseria gonorrhoeae: production of antibodies directed against a strain-specific cell surface antigen.
Creators: name: Mittler, R
name: Nachamkin, I
name: Cannon, J
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1981

description: Hybridomas secreting monoclonal antibodies against an apparent strain-specific cell surface antigen of Neisseria gonorrhoeae were produced. Spleen cells from BALB/c mice immunized with whole gonococci were fused with mouse myeloma cell line Sp2/0, and hybrid cells were selected in culture. One hybridoma that secreted antibodies reactive with the immunizing strain was cloned by limiting dilution to obtain cell lines secreting monoclonal antibodies. These antibodies reacted with purified outer membranes from the immunizing strain as well as with whole gonococci. Binding of antibodies to whole gonococci was highly strain specific, with most gonococcal strains showing less than 1% of the binding with the immunizing strain. Antibodies did not bind to the other Neisseria species tested. Binding of monoclonal antibodies to whole gonococci of the immunizing strain was not dependent on state of piliation. The extent of antibody binding did vary in different colonial variants of the immunizing strain. Antibody bound to cells from colonies that were transparent or of intermediate opacity, but did not bind to cells from deeply opaque colony variants.
Structures of all natural rupestines, NMR spectrum of compounds 8~15, 5A~5D, experimental ECD and calculated ECD of compounds 5A~5D, optical rotation spectrum of compounds 5A~5D from Total synthesis of rupestine G and its epimers.
Creators: name: Yusuf, Abdullah
name: Jiangyu Zhao
name: Bianlin Wang
name: Paruke Aibibula
name: Haji Akber Aisa
name: Guozheng Huang
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Organic Chemistry
subject: FOS: Chemical sciences
subject: 30306 Synthesis of Materials
subject: 30503 Organic Chemical Synthesis

description: Structures of all natural rupestines, NMR spectrum of compounds 8~15, 5A~5D, experimental ECD and calculated ECD of compounds 5A~5D, optical rotation spectrum of compounds 5A~5D
Making “sense” out of surface area to volume relationships
Creators: name: Snyder, Jenise
Publisher: name: QUBES Educational Resources
Year: 2023

description: Using a multimodal approach, the non-linear aspect of the surface area to volume relationship is explored. Students use their their senses of taste and sight to determine how smaller cells and larger cells differ. Quantitative examples are explored. Concepts of structure and function Examples along the biological hierarchy are provided.
Arthropathic Properties Related to the Molecular Weight of Peptidoglycan-Polysaccharide Polymers of Streptococcal Cell Walls
Creators: name: Anderle, Sonia
name: Gooder, Harry
name: Brown, Roger
name: Cromartie, William
name: Schwab, John
name: Fox, Alvin
name: Chetty, Chamroen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1982

description: The covalently bound polymers of peptidoglycan and group-specific polysaccharide (PG-APS) were isolated from the cell walls of group A streptococci. Arthritis was induced in rats with a single intraperitoneal injection of an aqueous suspension of PG-APS fragments derived by sonication. The joint lesions induced with this polydisperse suspension followed a bimodal pattern consisting of an acute phase, which reached a peak 5 days after injection and then receded, followed by a chronic, remittent, erosive arthritis lasting several months. The relative severities of the acute and chronic phases could be manipulated by selection of the size of PG-APS fragments. The fragments of PG-APS obtained by sonic treatment were resolved on the basis of size into three major populations by sucrose gradient or differential centrifugation. Based upon light scattering and gel filtration, the average molecular weight of the largest family of fragments was estimated to be about 500 x 10(6), the intermediate fragments were 50 x 10(6) daltons, and the predominant size in the smallest population was 5.3 x 10(6) daltons. The larger fragments induced negligible acute inflammation, but chronic disease became apparent 5 to 9 weeks after injection. The smallest fragments induced the most severe acute inflammation, with relatively little late, chronic joint disease. The particles of intermediate size induced moderate acute inflammation and the most severe chronic, erosive joint lesions. A single injection of fragments of the isolated peptidoglycan moiety of the PG-APS induced only a moderate acute inflammation of joints, with no apparent capacity to maintain the injury and induce chronic disease.
(400675) Beatrice Carmichael
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Structures of all natural rupestines, NMR spectrum of compounds 8~15, 5A~5D, experimental ECD and calculated ECD of compounds 5A~5D, optical rotation spectrum of compounds 5A~5D from Total synthesis of rupestine G and its epimers
Creators: name: Yusuf, Abdullah
name: Jiangyu Zhao
name: Bianlin Wang
name: Paruke Aibibula
name: Haji Akber Aisa
name: Guozheng Huang
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Organic Chemistry
subject: FOS: Chemical sciences
subject: 30306 Synthesis of Materials
subject: 30503 Organic Chemical Synthesis

description: Structures of all natural rupestines, NMR spectrum of compounds 8~15, 5A~5D, experimental ECD and calculated ECD of compounds 5A~5D, optical rotation spectrum of compounds 5A~5D
Compound synthesis and spectral characterisation from In situ epoxide generation by dimethyldioxirane oxidation and the use of epichlorohydrin in the flow synthesis of a library of β-amino alcohols.
Creators: name: Cossar, Peter J.
name: Baker, Jennifer R.
name: Cain, Nicholas
name: McCluskey, Adam
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Organic Chemistry
subject: FOS: Chemical sciences
subject: 30499 Medicinal and Biomolecular Chemistry not elsewhere classified

description: Compound synthesis, optimisation and spectral characterisation
Cytotoxic cells induced after Chlamydia psittaci infection in mice.
Creators: name: Lammert, J
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1982

description: The ability of spleen cells from Chlamydia psittaci-infected mice to lyse C. psittaci-infected and uninfected target cell monolayers was studied. The cytotoxicity assay used was a terminal label method in which the number of adherent target cells surviving the interaction with effector cells was determined by measuring the uptake of [3H]uridine by such cells. It was observed that in the first few days postinfection (3 to 5), spleens contained cells that lysed infected and uninfected targets with equal efficiency. Subsequently, infected targets were killed primarily. The activity of effector spleen cells for infected targets continued, although at a reduced level, beyond 21 days postinfection. Intact effector cells were required since a disruption by sonication resulted in a loss of cytotoxicity. The enhanced killing observed with infected targets was also observed when target cells were sensitized with heat- or UV-inactivated C. psittaci. This study suggests that the induction of cytotoxic cells after C. psittaci infection may contribute to the ability of the host to control multiplication of the microorganism.
Compound synthesis and spectral characterisation from In situ epoxide generation by dimethyldioxirane oxidation and the use of epichlorohydrin in the flow synthesis of a library of β-amino alcohols
Creators: name: Cossar, Peter J.
name: Baker, Jennifer R.
name: Cain, Nicholas
name: McCluskey, Adam
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Organic Chemistry
subject: FOS: Chemical sciences
subject: 30499 Medicinal and Biomolecular Chemistry not elsewhere classified

description: Compound synthesis, optimisation and spectral characterisation
Chimera patterns under the impact of noise
Creators: name: Loos, Sarah A. M.
name: Claussen, Jens Christian
name: Schöll, Eckehard
name: Zakharova, Anna
Publisher: name: arXiv
Year: 2015
Subjects: subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: FOS: Physical sciences

description: We investigate two types of chimera states, i.e., patterns consisting of coexisting spatially separated domains with coherent and incoherent dynamics, in ring networks of Stuart-Landau oscillators with symmetry-breaking coupling, under the influence of noise. Amplitude chimeras are characterized by temporally periodic dynamics throughout the whole network, but spatially incoherent behavior with respect to the amplitudes in a part of the system; they are long-living transients. Chimera death states generalize chimeras to stationary inhomogeneous patterns (oscillation death), which combine spatially coherent and incoherent domains. We analyze the impact of random perturbations, addressing the question of robustness of chimera states in the presence of white noise. We further consider the effect of symmetries applied to random initial conditions.
Nair,Fiegna&Velicer_methods_tables_figures_ESM.pdf from Indirect evolution of social fitness inequalities and facultative social exploitation.
Creators: name: Ramith R. Nair
name: Fiegna, Francesca
name: Velicer, Gregory J.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Ecology

description: Microbial genotypes with similarly high proficiency at a cooperative behaviour in genetically pure groups often exhibit fitness inequalities caused by social interaction in mixed groups. Winning competitors in this scenario have been referred to as ‘cheaters’ in some studies. Such interaction-specific fitness inequalities, as well as social exploitation (in which interaction between genotypes increases absolute fitness), might evolve due to selection for competitiveness at the focal behaviour or might arise non-adaptively due to pleiotropy, hitchhiking or genetic drift. The bacterium Myxococcus xanthus sporulates during cooperative development of multicellular fruiting bodies. Using M. xanthus lineages that underwent experimental evolution in allopatry without selection on sporulation, we demonstrate that interaction-specific fitness inequalities and facultative social exploitation during development readily evolved indirectly among descendant lineages. Fitness inequalities between evolved genotypes were not caused by divergence in developmental speed, as faster-developing strains were not over-represented among competition winners. In competitions between ancestors and several evolved strains, all evolved genotypes produced more spores than the ancestors, including losers of evolved-versus-evolved competitions, indicating that adaptation in non-developmental contexts pleiotropically increased competitiveness for spore production. Overall, our results suggest that fitness inequalities caused by social interaction during cooperative processes may often evolve non-adaptively in natural populations.
Effects of immunosuppression with cyclophosphamide on acute murine cytomegalovirus infection and virus-augmented natural killer cell activity.
Creators: name: Hu, P
name: Daniels, M
name: Miller, F
name: Graham, J
name: Selgrade, M
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1982

description: The effects of cyclophosphamide (CY) treatment on acute murine cytomegalovirus (MCMV) infection were studied to explore the potential usefulness of MCMV as a means of detecting immune dysfunction and to identify host defense mechanisms important for protection against MCMV. Conditions found optimal for enhancing MCMV infection with CY included infecting adult mice with 2 X 10(5) PFU or more of virus and administering 80 mg or more of CY per kg 1 to 3 days later. In addition to enhanced mortality, virus titers in lung, liver, and spleen were elevated in CY-treated mice, and wet weights of liver, spleen, and thymus were depressed when compared with those of infected but untreated mice. Treatment with CY before MCMV challenge was not as efficient a means of enhancing mortality as treatment after virus challenge. The effect that the time of CY administration relative to infection had on mortality correlated with the effect of such timing on natural killer cell activity. Animals treated before infection exhibited depressed natural killer cell activity initially. However, they rapidly recovered this response, and by 5 days postinfection they had the same level of virus-augmented activity seen in untreated mice. In contrast, animals treated after infection did not recover natural killer cell activity and were more likely to die. A similar correlation was not obtained when the effects of CY on lymphocyte responses to B and T cell mitogens were examined, nor were there striking differences in pathology between the treatment groups. The data suggest an important role for natural killer cells in host defense against MCMV. Also, increased susceptibility to MCMV may provide a useful indicator of deficits in the natural killer cell response.