title: ÐÐµÑÐ¾Ð´Ñ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° ÑÐ¸Ð³Ð½Ð°Ð»ÑÐ½ÑÑ Ð¿Ð¾ÑÐ¾ÐºÐ¾Ð² Ð² ÑÐ¸Ð³Ð½Ð°Ð»ÑÐ½ÑÑ ÑÐµÑÑÑ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Methods for analyzing signal flows in signal networks
Creators: name: ÐÐ²ÐµÐ·Ð´Ð¸Ð½, ÐÐ½ÑÐ¾Ð½
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2023
Subjects: ÑÐ¸Ð³Ð½Ð°Ð»ÑÐ½ÑÐµ ÑÐµÑÐ¸
Ð³ÑÐ°ÑÑ
ÑÐ°ÑÐ¿ÑÐ¾ÑÑÑÐ°Ð½ÐµÐ½Ð¸Ðµ ÑÐ¸Ð³Ð½Ð°Ð»Ð°
Ð¾ÑÐ½Ð¾ÑÐ¸ÑÐµÐ»ÑÐ½Ð°Ñ ÑÐ½ÑÑÐ¾Ð¿Ð¸Ñ
signal networks
graphs
signal propagation
relative entropy

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description: The purpose of the work was to study the topology of signaling networks formed by biochemical reactions in living systems and performing the biological function of signal transmission from one molecule to another. Using the well-known algorithm for estimating the signal flow in such networks, an analysis was made of the uniqueness of biological signal networks in comparison with random networks with similar topological characteristics in terms of the value of the signal flow. Two characteristics of the signal flow were proposed for comparison between a biological network and random networks - the value of the signal flow at the output node of the graph and the average KullbackâLeibler distance between the distributions of the sig-nal flow over all nodes within a given network and within a random network. It is shown that the values of both characteristics for several considered biological net-works are statistically significantly different from the values for the set of generated random networks. Based on the results obtained, it can be assumed that the proposed characteristics of signal flows can serve as objects of evolutionary selection, which resulted in the formation of structures of biological signal networks as effective tools for signal transmission.