cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Mechanisms and inhibition of HIV-1 capsid assembly.
Creators: name: Wang, Hui
Publisher: name: University of Utah
Year: 2012
Subjects: Proteasome, Crystallography
Sevenfold Symmetry

description: The human immunodeficiency virus type 1 (HIV-1) initially assembles as a spherical, immature particle organized by the Gag polyprotein. As the virus buds, Gag is cleaved into three structural proteins: MA, CA, and NC. Upon Gag processing, CA condenses to form the conical viral capsid of the mature virus. Proper assembly of the capsid is essential for viral infectivity, and this process requires accurate and ordered processing at both ends of CA. The structures of the N- and C-terminal domains of CA (NTD and CTD), which presumably represent CA in its mature conformation, were solved previously. To examine CA in its immature conformation, CA molecules with N- and C terminal extensions were characterized biochemically and structurally. The solution structure of the N-terminal domain of CA fused to the final four MA residues (129MA-CA278) revealed that there are significant structural rearrangements at the N-terminal end of CA upon proteolysis. In comparison with the structure of fully processed CA NTD, the N-terminal beta-hairpin and surrounding helices 1, 3, and 6 are significantly reoriented. Thus, we speculate that these rearrangements are required for the conformational polymorphism displayed by CA, either in the pentamer and hexamer formation of the mature viral capsid, or in viral maturation. The structure of the C-terminal domain of CA fused to the 14-residue p2 region (CA146-p2) was determined by X-ray crystallography. Unfortunately, the region encompassing the C-terminus of CTD and p2 residues was disordered in the crystal lattice and no conformational differences were observed in comparison of the CA146-p2 with the fully processed CA CTD. However, this result does not exclude the possibility that this region may adopt ordered structures when engaging in Gag-Gag interactions, which could help regulate capsid maturation. Inhibitors that target the structural CA protein are potentially complementary to the drugs used in current combination chemotherapy (inhibitors of HIV-1 protease and reverse transcriptase). Three assays that can be used to identify inhibitors of CA maturation, CA dimerization, and CA-NC assembly were therefore designed and optimized. Potentially, inhibiting different stages of capsid assembly will provide a novel mechanism of action for treating HIV/AIDS.
title: Dagbani English : The Influence of Dagbani on the Use of English in Ghana
Creators: name: Sheini, Memunatu
Publisher: name: University of Bayreuth
Year: 2022
Subjects: subject: Dagbani
subject: Mabia (Gur)
subject: Influence
subject: Grammar
subject: Phonology
subject: British and Ghanaian Englishes
subject: 400
subject: 490

description: This study investigates the influence of the Dagbani language on the Dagomba’s use of English in Ghana. Dagbani, one of the Mabia (Gur) languages spoken in Northern Ghana, and English exhibit some differences grammatically and phonologically. Scholars have discussed Dagbani grammar and phonology. However, its influence on English has not received scholarly attention. In this study, I investigate how the Dagbani perfective, imperfective, and phonological features influence Dagomba’s use of English. The study uses the Dynamic Model of Postcolonial English (Schneider 2007) and the Grammatical Replication Theory (Heina and Kuteva 2006) to explore the influence of Dagbani phonological features as well as the perfective and imperfective aspects on the use of English by native speakers of this language. Data were collected from 89 basic (30), secondary (30) and tertiary (29) level students in Tamale and Yendi. The data were gathered through sentence translation, picture description, and simple text reading tasks. Simple sentence translation and picture description tasks were used to gather data on the possible grammatical influence while the text reading task was for data on phonological features. Descriptive statistical methods were used to analyse the data. The Praat software was employed to describe the phonological features. The analysis is presented in graphs. The findings show that Dagbani English DagbE is heavily influenced by Dagbani L1 features, which distinguish it from Ghanaian English (GhE) and British English (BrE).
Tectonaquinones A, B and C: three new naphthoquinone derivatives from the heartwood of Tectona grandis
Creators: name: Vyas, Pooja
name: Wadhwani, Barkha Darra
name: Khandelwal, Poonam
name: Araya, Hiroshi
name: Fujimoto, Yoshinori
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Chemical investigation of the chloroform extract of heartwood of Tectona grandis L. f. led to the isolation of three new naphthoquinone derivatives, tectonaquinones A (1), B (2) and C (3), along with six known compounds: barleriaquinone-I (4), tectoquinone (5), tecomaquinone I (6), lapachol (7), obtusifolin (8) and 2-hydroxy-3-methyl anthraquinone (9). The structures of the new compounds were elucidated by spectroscopic methods including 2 D NMR experiments. Tectonaquinone B is the first natural compound that has a hexa-cyclic dinaphthofuran-dione scaffold. Tectonaquinone C has a bicyclic acetal motif that is unusual in nature.
Dorysthetus cayennensis Ohaus 1905
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Rutelidae
Dorysthetus
Dorysthetus cayennensis

description: Dorysthetus cayennensis Ohaus, 1905
Dorystethus [sic] taeniatus cayennensis Ohaus 1905b: 297 (French Guiana) Distribution. French Guiana: Ohaus 1905b: 297 (as Dorystethus [sic] taeniatus cayennensis), 1934: 148 (as Antichira taeniata cayennensis); Blackwelder 1944: 241 (as Antichira taeniata cayennensis); Machatschke 1972: 68 (as Anticheira taeniata cayennensis); Soula 1998: 83, 2003: 64, 2010a: 58; RMNH.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 132, DOI: 10.5281/zenodo.3678492
Role of APC and retinoid metabolism in gut development and cancer progression
Creators: name: Shelton, Dawne Naomi
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Colon Cancer
subject: Genetics
subject: FOS: Biological sciences
subject: Zebra danio
subject: Physiology

description: This work explores the dysregulation of retinoid metabolism in early oncogenesis models, and the role of retinoids in early development of the intestine. APC is a tumor suppressor gene mutated or silenced in -85% of all colorectal cancers. Through the canonical pathway, APC negatively regulates protein levels of the transcriptional activator, beta catenin. Under Wnt signaling or mutated APC, beta catenin accumulates, and translocates to the nucleus where it binds to TCF/LEF transcription factors and activates Wnt target genes involved in proliferation. In this dissertation I will provide evidence that in addition to the canonical pathway and excessive proliferation, mutations in APC also lead to defects in retinoid metabolism which contributes to a lack of appropriate differentiation within the intestine, contributing to oncogenic progression.  Work in our lab has focused on a role for APC in the regulation of retinoic acid (RA) metabolism; production, catabolism, and transport. Using zebrafish as a model system, I will show that certain retinol dehydrogenases (rdhs) are regulated by APC and mutations in APC lead to their loss. The defects seen in apc[mcr] mutants phenocopy antisense morpholino gene knockdowns of ape and certain rdhs, in addition to having characteristic phenotypes of RA deficiency. These phenotypes include loss of jaw and fin structures and terminal differentiation of the pancreas, intestine, liver, and eye. These phenotypes can be rescued by the addition of exogenous RA or the injection of ape or rdh mRNAs. In addition to this, I will show that through the canonical pathway, catabolism of RA is up regulated in three vertebrate model systems; apc[mcr] zebrafish, Apc[Min] mouse model, and human familial adenomatous polyposis (FAP) syndrome. Inhibition of the enzyme responsible for degradation of RA, Cyp26al, leads to increased levels of rescue of RA deficient phenotypes. Thirdly, I will report on the effects of knocking down retinol binding protein 2a (rbp2a) and retinoid transport in zebrafish and how it affects intestinal and ocular development. In Chapter 5 I will also present data on the consequences of crossing Apc'^' mice with Cyp26al knockout mice, which are embryonic lethal due to RA teratogenicity. These data, together, will support a model wherein APC regulates RA metabolism at several levels and contributes to an alternate model suggesting that loss of differentiation, in addition to increases in proliferation, facilitate the progression of colon cancer. In addition, the elucidation of these alternative pathways provides potential targets for future therapeutic and diagnostic needs.
Sonnenfleckenzeichnung Nr. 22978.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 21.01.1969, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1969

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 05.03.1969, erstellt am Sonnenobservatorium Kanzelhöhe, Kärnten
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1969

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage im Sonnenobservatorium Kanzelhöhe in Sattendorf, Österreich. Später wurden ergänzende Angaben aufgrund weiterer Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Instrument: Heliostat mit Refraktor Eigenbau (Öffnung 110mm, f = 1650mm, projiziertes Sonnenbild D = 25cm)
Inhalt
Creators: name: Redaktion, Die
Publisher: name: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Year: 2022

description: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege, Bd. 58 Nr. 4 (2017): Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege
Two new glycosides, farnesyl pentaglycoside and oleanane triglycoside from Lepisanthes rubiginosa, a mangrove plant collected from Thua Thien-Hue province, Vietnam
Creators: name: Van Tran, Loc
name: Thi, Ninh Pham
name: Thi, Luu Nguyen
name: Van Tran, Chien
name: Vo, Nhu Thi Quynh
name: Ho, Anh Ngoc
name: Cong, Viet
name: Tran, Van Sung
name: Tran, Thao Thi Phuong
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Phytochemical investigation of the leaves of Lepisanthes rubiginosa led to the isolation of two new glycosides, lepisantheside A (1) and lepisantheside B (2), together with two known compounds acutoside A (3) and 3-O-[β-D-xylopyranosyl-(1→3)-β-D-glucopyranosyl-]-oleanolic acid (4). Their structures were elucidated by means of spectroscopic methods (HR-ESI-MS, 1D and 2D NMR), and by comparison with the reported data. The cytotoxicity of compounds 1–4 against four human cancer cell lines (KB, HepG2, SK-LU-1 and MCF7) was evaluated. Compound 4 exhibited significant activity with IC50 values of 9.57, 6.66, 6.97 and 18.32 µM, respectively, in comparison with the postive control ellipticine.
Untitled Item
Creators: name: Ifeoma Enweani
Publisher: name: figshare
Year: 2020
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: It is very unfortunate that in the 21st century, Nigeria is still lagging far behind in respect ofwomen education especially in science based disciplines. In as much as there are paucity ofdata as regards women scientists in Nigeria, it is my humble opinion that women who are inscience-based disciplines in our tertiary institutions are about 25%. The factors that appear toinfluence gender-specific differences in scientific achievements in primary, secondary andtertiary levels include: policy factors, academic factors, cultural and societal expectations fgender roles. Girls are expected in our culture to marry early as a lot of dignity is attached tomarriage. Where there is inadequate funding; only boys are trained at the expense of girls. Forthe fact that education is very poorly funded in Nigeria, coupled with high inflation, it isobserved that parents are finding it extremely difficult to cope with financing of their children’sand wards education. The girl child is always seen as the sacrificial lamb. Efforts should bedirected at providing equal access to resources in form of adequate funding of educationalsector, grants and scholarships specifically for women in science and removal of social stigmaon women who are unmarried.
Sonnenfleckenzeichnung Nr. 22971.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 13.01.1969, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1969

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
A longitudinal study of early English; immersion and literacy in Xi'an, China
Creators: name: Knell, Ellen Shipley
Publisher: name: University of Utah
Year: 2012
Subjects: English
as a foreign language (EFL)
language teaching
oral language proficiency
Immersion programs
Second language (L2) literacy
Second language (L2) reading comprehension

description: The present study investigated the efficacy of early English; immersion in the Shi Da Fu Elementary School in Xi'an, China. Three hundred and fifty one students were  tested in Grades 1-6. There were two main purposes that motivated this longitudinal and cross-sectional study. The first goal was to compare the L1 and L2 language and literacy performances of the immersion students to a comparable group of children who attended the same school and were taking English; as a core subject. The second purpose was to investigate which variables successfully predicted L2 English; word identification and  reading comprehension for the combined group of students. After pretest scores were controlled, it was found that the immersion students significantly performed at a higher level than the nonimmersion students on measures of oral language proficiency, vocabulary, phonological awareness, pseudoword decoding, reading identification, and reading comprehension, but there were no significant differences on measures of alphabet recognition, morphological awareness, or written grammar.
Dorysthetus corruscus
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Rutelidae
Dorysthetus
Dorysthetus corruscus

description: Dorysthetus corruscus (Le Peletier and Serville, 1825)
Rutela corrusca Le Peletier and Serville 1825: 317 (French Guiana - NEOTYPE)
Distribution. Suriname: MHCN - NEW COUNTRY RECORD (Suriname, Sipaliwini.). French Guiana: Le Peletier and Serville 1825: 317 (as Rutela corrusca); Ohaus 1934: 148 (as Antichira corrusca); Blackwelder 1944: 241 (as Antichira corrusca); Machatschke 1972: 67 (as Anticheira corrusca); Soula 1998: 79, 112 (designation NEOTYPE Rutela corrusca), 2003: 60, 2010a: 58.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 133, DOI: 10.5281/zenodo.3678492
Supercritical extraction of volatile and fixed oils from Petroselinum crispum L. seeds: chemical composition and biological activity
Creators: name: Piras, A.
name: Porcedda, S.
name: Falconieri, D.
name: Fais, A.
name: Era, B.
name: Carta, G.
name: Rosa, A.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: The supercritical fluid extraction (SFE) of volatile and fixed oil from milled parsley (Petroselinum crispum L.) seeds, using CO2 as solvent, is presented in this study. Extraction experiments were carried out in two steps: at pressures of (90 or 300) bar and temperature of 40 °C. The first extraction step, performed at 90 bar, produced a volatile fraction mainly formed by apiole (82.1%) and myristicin (11.4%). The volatile oil yield was 2.6% by weight of the charge. The second extraction step, carried out at 300 bar produced a fixed oil at a yield of 0.4% by weight. The most represented fatty acids in P. crispum fixed oil were 18:1 n-12 (49.9%), 18:2 n-6 (18.2%), 18:1 n-9 (11.8%), and 16:0 (7.4%). In particular, the unsaturated fatty acids 18:1 n-12 and 18:1 n-9 averaged 182.2 mg/g and 92.1 mg/g of oil extract, respectively. The quality of the oils extracted by SFE, in terms of its chemical composition, was compared to the oils obtained by hydrodistillation (HD) in a Clevenger apparatus and by solvent extraction (SE) using n-hexane in a Soxhlet apparatus. The antioxidant properties were determined by means of the ABTS assay. The results indicated that the fixed oil possessed low antioxidant activity (EC50 = 0.4 mg/mL) and the volatile oil had no antioxidant activity. The total phenolic content, expressed as concentration of gallic acid (gallic acid equivalent, GAE), of the fixed oil was 1.5 mg/g. The fixed oil found to have inhibitory effects against α-glucosidase, the volatile oil is active on acetylcholinesterase (AChE), tyrosinase, and α-glucosidase. Both samples have weak inhibitory activity on α-amylase and no activity on butyrylcholinesterase (BChE).
Sarcoroseolides A-D, four undescribed cembranoids from the Red Sea soft coral Sarcophyton roseum
Creators: name: Ahmed, Mohammed M. A.
name: Albadry, Mohamed A.
name: Ragab, Ehab A.
name: El-Ghaly, Elsayed M.
name: Ismail, Said K.
name: Ali, Zulfiqar
name: Khan, Shabana I.
name: Chittiboyina, Amar G.
name: Khan, Ikhlas A.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: Four undescribed cembranoids, sarcoroseolides A-D (1-4) along with nine reported related cembranoids (5-13) were isolated from the soft coral Sarcophyton roseum. The chemical structures of sarcoroseolides A-D were elucidated by extensive 1 D and 2 D NMR as well as HR-ESIMS spectroscopic data. Moreover, the geometric and absolute configurations were assigned by the modified Mosher’s method and/or NOESY experiments. The extract and the isolated metabolites were evaluated for their potential anti-inflammatory and cytotoxic activities.
Reviewing, Evaluating, Editing and Research Integrity: An Educational Scenario by the EnTIRE project
Creators: name: Kakuk, Péter
Publisher: name: Zenodo
Year: 2020
Subjects: research integrity
research ethics

description: Members of The Embassy of Good Science have developed a set of eight scenarios for educational purposes and to stimulate strategic thinking about issues in research ethics and research integrity. This scenario presents a hypothetical narrative concerning the ethical and integrity standards governing peer review processes. It focuses on issues regarding: The integrity of peer review processes; Institutional obligations to upholding the standards of good peer review practices; Plagiarism. It is interspersed with questions and resource suggestions that help guide researchers, research ethics committees ('RECs'), research integrity offices ('RIOs') and research administrators in their deliberations concerning the research integrity issues raised by the narrative.
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 17.03.1969, erstellt am Sonnenobservatorium der Universität Teheran
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1969

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Solar Physics Observatory, Geophysical Institute, Teheran University (Tehran). Instrument: unbekannt
Inhalt
Creators: name: Redaktion, Die
Publisher: name: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Year: 2022

description: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege, Bd. 58 Nr. 3 (2017): Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 22.04.1969, erstellt am Kandilli Observatorium Istanbul
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1969

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Istanbul Kandilli Rasathanesi, Çengelköy (Istanbul). Instrument: Refraktor Teleskop (Öffnung 200 mm, f = 3070 mm, projiziertes Sonnenbild D = 25 cm).
Instrumentennachweis gemäss Kandilli Observatory Istanbul, Report from Solar Institute, in: Solar Physics, 1968, Vol. 3, Issue 3, pp.491-492, DOI: https://doi.org/10.1007/BF00171622
Perflexmea: a multielectrode array for cell culture on a thin perforated flexible polycarbonate membrane
Creators: name: Mondal, Abhijit
Publisher: name: University of Utah
Year: 2012
Subjects: Excitable cells
Flexible
Multielectrode array
Perforated
Polycarbonate
PerFlexMEA

description: Over the past four decades, Multielectrode Array (MEA) devices have played a major role in electrophysiology by providing a simpler solution to simultaneous multi-site  chronic extracellular recording: in vivo and in vitro. While a wide range of devices have been developed, almost all of them are limited to culturing and recording from one cell type, in vitro; and tissue surfaces, in vivo and in vitro. Most tissues are formed by different cell types that interact to maintain tissue function, like the heart which is composed mainly of cardio-myocytes and fibroblasts. Direct recording from such organs usually employs plunge-type electrodes which induce tissue damage and require better handling for sustenance. To better understand the functioning of such tissues, it is imperative to utilize recording systems that allow interactions between two or more cell types and at the same time sustain cultures with controlled cell number and distribution.   In this thesis, the design, fabrication process, and characterization of an MEA device called the PerFlexMEA (Perforated Flexible MEA) is presented. It enables the  generation and sustenance of a preparation with two cell types while recording their electrical activity. PerFlexMEA was developed using a thin (9?m) perforated  Polycarbonate Track Etch (PCTE) membrane (3?m diam. pores, 200,000 pores/cm2) as substrate where cells can be cultured on both sides, allowing gap junction formation  across the membrane via the pores. Cell number and distribution can be controlled on either side. The PerFlexMEA comprises a 4 × 5 array of square gold electrodes, each measuring 50 ?m × 50 ?m spaced 500 ?m apart. Parylene was patterned to insulate the leads (50 ?m thick) connecting the recording electrodes to the contact pads. A coinshaped device was designed to house the PerFlexMEA and to insulate its cell culture  zone (wet) from contact pads (dry). Cardiomyocytes, isolated from neonatal mice were plated on the recording side of PerFlexMEA and electrical activity was recorded at a signal to noise ratio of 8.6 and peak to peak voltage of 200 ?V.
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 20.02.1969, erstellt von Samet Marsoglu an der Universitätssternwarte Istanbul
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1969

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Istanbul Universitesi Observatuari, Beyazit (Istanbul). Instrument: Zeiss Refraktor Teleskop (Öffnung 130 mm, f = 2000 mm, projiziertes Sonnenbild D = 25 cm)
Dorysthetus fulgidus
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Rutelidae
Dorysthetus
Dorysthetus fulgidus

description: Dorysthetus fulgidus (Waterhouse, 1881)
Antichira fulgida Waterhouse 1881: 542
Note. Two presently recognized subspecies of Dorysthetus fulgidus have been described, both of which occur in the research area.
Subspecies Dorysthetus fulgidus fulgidus (Waterhouse, 1881)
Antichira fulgida Waterhouse 1881: 542 (Peru?)
Distribution. Suriname: NZCS - NEW COUNTRY RECORD (Suriname, [Sipaliwini], Oelemarie, [3°06′N, 54°32′W], Base Camp. 21-IV-1998. B. De Dijn.). Brazil (NA): Blackwelder 1944: 241 (as Antichira fulgida); Machatschke 1972: 68 (as Anticheira fulgida); Soula 1998: 74, 2002a: 285 (NA), 2003: 56, 2005: 385 (NA); Ferreira et al. 2011: 367 (NA). “Amazon Basin”: Ohaus 1934: 148 (as Antichira fulgida). Other: Waterhouse 1881: 542 (Peru - as Antichira fulgida); Ohaus 1934: 148 (Ecuador, Peru - as Antichira fulgida); Blackwelder 1944: 241 (Ecuador, Peru - as Antichira fulgida); Machatschke 1972: 68 (Ecuador, Peru - as Anticheira fulgida); Soula 1998: 74 (Colombia, Ecuador, Peru), 2003: 56 (Colombia, Ecuador, Peru); Ferreira et al. 2011: 367 (Colombia, Ecuador, Peru).
§ Subspecies Dorysthetus fulgidus neblinensis Soula, 2006
Dorysthetus fulgidus neblinensis Soula 2006: 154 (Venezuela (EO))
Distribution. Venezuela (EO): Soula 2006: 154 (EO).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 133, DOI: 10.5281/zenodo.3678492
Liquefaction-induced ground displacement mapping for the Salt Lake Valley, Utah
Creators: name: Hinckley, Daniel W
Publisher: name: University of Utah
Year: 2012
Subjects: Soil liquefaction--Utah
Wasatch fault

description: This paper presents liquefaction-induced lateral spread and ground settlement  maps for the Salt Lake Valley for a M7.0 scenario event on the Wasatch fault and for two  probabilistic-based events: (1) peak ground acceleration associated with a 2 percent  probability of exceedance in 50 years and (2) peak ground acceleration associated with a  10 percent probability of exceedance in 50 years. The maps presented herein are the first  liquefaction-induced ground failure maps developed for Utah using both geotechnical and  geological data in conjunction with deterministic and probabilistic estimates of strong  motion. These maps have been developed to aid engineers, developers and city planners  identify areas that may require additional geotechnical evaluations and/or liquefaction  mitigation to reduce the liquefaction hazard. The maps were developed from an  extensive geotechnical database, geologic mapping and hazard calculations. Estimates of  lateral spread displacement were calculated from the Youd and others regression model  and ground settlement estimates were calculated from procedures developed by  Tokimatsu and Seed, and Yoshimine and others. Estimates from these methods were  plotted within their respective surficial geologic units, and the mapped units were  subsequently assigned an estimate of ground displacement based on statistical analysis.  The mapped units for the scenario event were assigned a displacement hazard that has an  85 percent probability of nonexceedance for the M7.0 Wasatch fault characteristic  earthquake while the probabilistic-based events were assigned the median displacement hazard for their respective probabilistic events. The maps show relatively high lateral  spread and settlement hazards exist along and near the Jordan River and in recent  alluvial/river/stream/lake deposits found in the northern part of the Salt Lake Valley.
Areal geology of the Wanship-Coalville Area
Creators: name: Johnson, Melvin Coatany
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences
subject: Utah
subject: Wanship region
subject: Coalville region
subject: Thesis and dissertation georeferencing project

description: The writer is greatly indebted to Dr. A. J. Eardley for introducing him to the thesis problem, for guidance, and for critical reading of the manuscript. Thanks are also due Professors R. E. Marsell, W. L. Stokes, and N. C. Williams, of the Department of Geology, University of Utah, for valuable suggestions in treatment of the various problems, and to Bob Holt and Dean Webb for assistance in measuring sections. The many kindnesses and courtesies of the residents of the area which ere extended to the writer, especially those of Mrs. Edna V. Judd, Roy Judd, and Grant Judd are also graterfully acknowledged.
Policy analysis of kinship foster care in eleven Western States
Creators: name: Kida, Yuri
Publisher: name: University of Utah
Year: 2012
Subjects: Foster home care
Kinship care

description: Kinship foster care is care by relatives or close family friends. The definition of kin varies from state to state. Some states define kin as relatives and others include close family friends in addition to relatives. There are some concerns about kinship care; however, past research has found benefits from kinship placements for children. Children in kinship care experience fewer placements and they are less likely to come back to the  child welfare system once they are reunified with their families than children in other out of-home placements. Because of these findings, federal policies give preference for kinship placements as out-of-home placements over other forms of placements. Court  decisions also show preference for kinship placements. Even though states give preference for kinship placements as out-of-home placements, polices regarding kinship foster care differ from state to state. This research examines kinship care polices in eleven western states, compares these polices with Utah policy, and makes recommendations to Utah for better kinship care policy. The data were collected from 11 western states. A website search was done first. The websites I visited included state websites, federal government websites, and websites of organizations that support children and their caregivers. After concluding the internet search, emails were send to states welfare workers to find out the information that was not collected by internet search. A few phone calls were also made to get additional information.
Inhalt
Creators: name: Redaktion, Die
Publisher: name: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege
Year: 2022

description: Burgen und Schlösser - Zeitschrift für Burgenforschung und Denkmalpflege, Bd. 58 Nr. 2 (2017): Burgen und Schlösser. Zeitschrift für Burgenforschung und Denkmalpflege
A new lignan from the stem bark of Fagraea fragrans Roxb
Creators: name: Rattanaburi, Suthida
name: Kaikaew, Kaodeeya
name: Watanapokasin, Ramida
name: Phongpaichit, Souwalak
name: Mahabusarakamb, Wilawan
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: A new lignan, named fagraeanolide (1), and 14 known compounds were isolated from the stem bark of Fagraea fragrans Roxb. Their structures were determined by spectroscopic methods. Fagraeanolide is the first identified oxofurofuran lignan from the genus Fagraea, while β-boswelic acid (4), gentiogenol (5), 3-(4-hydroxy-3-methoxyphenyl)-acrylic acid octacosyl ester (7) and pinoresinol (14) were isolated from this plant for the first time. The crude extract of F. fragrans was not toxic to cell lines. The isolated compounds showed no antibacterial activity.
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 04.05.1969, erstellt von Simona Nicolescu, Observatorium Bukarest
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1969

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage am Astronomischen Observatorium Bukarest, Solarsektor, Rumänien. Später wurden ergänzende Angaben aufgrund weiterer Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Instrument: Zeiss-Refraktor (Öffnung 130mm, f = 1950mm, projiziertes Sonnenbild D = 25cm)
Data Science Team Personas: case study from The Alan Turing Institute
Creators: name: Karoune, Emma
name: Sharan, Malvika
Publisher: name: Zenodo
Year: 2024

description: This case study is one of the outputs from the Skills Policy Award project - Professionalising traditional and infrastructure research roles in data science.

In this case study, we capture how data science teams at The Alan Turing Institute are constructed, including personas of the roles:

Data Science Domain experts

Data Science Leaders

Cross-cutting Research Infrastructure Specialists

Research Data Scientists

Research Software Engineers

Research Computing and Infrastructure Engineers

Research Community Managers

Research Application Managers

Data Wranglers

Research and AI Ethicists

Public Engagement Practitioners

Project/Programme Managers

This document is the first version of the personas and is meant to be updated as practices and roles change and develop at the Turing.
Synthesis, structural revision, and tyrosinase inhibitory activity of proposed phloretin-4-O-β-D-glucopyranoside from Homalium stenophyllum
Creators: name: Shimakage, Ryo
name: Nihei, Ken-ichi
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology

description: Phloretin-4-O-β-D-glucopyranoside (1), isolated from Homalium stenophyllum, was synthesized for the first time through aldol condensation and Schmidt glycosylation reactions aiming to develop a novel hydrophilic tyrosinase inhibitor. However, the specific rotation of synthetic 1 was found to be negative and different from that reported for natural product 1. Thus, L-glucoside 2 was chemically synthesized using the established synthetic route of 1, suggesting that the configuration of the natural product 1 was the same as that of 2, as their specific rotation and spectroscopic data were also the same. In addition, the evaluation of the inhibitory activity of 1 and 2 against tyrosinase indicated that 2 was 1.4 times more potent than 1, but they were both relatively weak. Therefore, the enantiomeric analogues 1 and 2 were proved to be unique tyrosinase inhibitors due to the chiral recognition from the tyrosinase active site.
Dorysthetus genieri Soula 2005
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Rutelidae
Dorysthetus
Dorysthetus genieri

description: § Dorysthetus genieri Soula, 2005
Dorysthetus genieri Soula 2005: 366 (Venezuela (EO))
Distribution. Venezuela (EO): Soula 2005: 366 (EO).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 133, DOI: 10.5281/zenodo.3678492
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 15.02.1969, erstellt von Peter Rovithis, Eugenides Planetarium in Athen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1969

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Eugenides Planetarium in Athen der Eugenides Stiftung, Griechenland. Instrument: Zeiss (Coudé-Refraktor 150mm, projiziertes Sonnenbild D = 25cm)
Variables affecting children's blood pressures
Creators: name: Williams, Lora Jean Gardiner
Publisher: name: University of Utah
Year: 2012
Subjects: Pediatric Nursing
Hematocrit

description: The blood pressures of fifty hospitalized school age children were measured at interval to determine if the variables age, weight, sex, and the passage of time between readings have a significant effect on the systolic and diastolic blood pressures and the pulse pressure.  The variables age, weight, and quadratic change over time were found to be significant factors, while six, sex by time, and linear change over time were not.  The results show that diastolic values remain at relatively constant level during the ages five to eleven years.  Children's blood pressure values seem to be subject to diurnal fluctuations that should be considered when establishing limits of normalcy or when interpreting clinical values.
Implementation and evaluation of a real-time syndromic surveillance system for automatic detection of disease outbreaks in Utah
Creators: name: Gesteland, Per Hans
Publisher: name: University of Utah
Year: 2012
Subjects: Utah
Salt Lake City

description: The key to minimizing the effects of an intentionally caused disease outbreaks is early detection of the attack, rapid identification of the affected individuals and rapid initiafion of treatment. The terrorist attacks on September 11, 2001, and the Anthrax release in October 2001 made the establishment of a nafionwide early warning biosurveillance system, as a defense against these threats, a national priority. The 2002 Winter Olympics were held in Utah from February 8th to March 16, 2002, in the wake of these tragic events, making the need for biosurveillance during the Games paramount. The spirit of collaboration and unity inspired by the events of 9-11 and the Salt Lake 2002 Olympic Games in Salt Lake City provided the opportunity to demonstrate how a prototypic biosurveillance system could be rapidly deployed.  In seven weeks, a team of informaticists and public health specialists from Utah and Pittsburgh implemented the Real-time Outbreak Disease Surveillance (RODS) system in the State of Utah. The strategies and challenges of the implementation are discussed.  The RODS system operated by automatically classifying patients into syndrome categories of interest to public health based on their free-text"" chief complaint (CC), which was entered by triage nurses into computerized registration systems. We evaluated the accuracy of the complaint coder using two reference syndromic classification methods:  (1) manual     classification by UDOH officials of Emergency Department visits based on visit logs and selected chart review and (2) classification based on ICD-9 discharge diagnoses. UDOH classifications, CCs and discharge ICD-9 codes were available for 30,094 ED encounters during the study period. The sensitivity for detecting the respiratory, neurological and rash syndromes was 0.47 to 0.52 based on the UDOH reference and 0.60 to 0.72 based on ICD-9 codes. The sensitivity for detecting the gastrointestinal syndrome determined by UDOH and ICD-9 codes, were 0.71 and 0.74, respectively.  A complaint coder that classifies CC into syndromes extracted data from emergency department (ED) encounters. During the actual deployment, the RODS system detected 70%) of patients with gastrointestinal and 50%o of patients with respiratory, neurological and rash syndromes of public health interest in ""real-time.""""
Dorysthetus limbicollis
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Rutelidae
Dorysthetus
Dorysthetus limbicollis

description: § Dorysthetus limbicollis (Ohaus, 1938)
Antichira limbicollis Ohaus 1938: 260 (Venezuela (EO))
Distribution. Venezuela (EO): Ohaus 1938: 260 (as Antichira limbicollis) (EO); Blackwelder 1944: 241 (as Antichira limbicollis); Machatschke 1972: 69 (as Anticheira limbicollis) (EO); Soula 1998: 74, 2003: 56.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 133, DOI: 10.5281/zenodo.3678492
Function and Biosynthetic Regulation of Retinoic Acid in Intestinal Development and Homeostasis
Creators: name: Broadbent, Talmage Jay
Publisher: name: University of Utah
Year: 2012
Subjects: Tretinoin
Intestines

description: It has been hypothesized for almost 100 years that retinoids could play a role in  regulating the differentiation and proliferation of epithelial tissues including the intestine.  Some of those original questions still remain as studies to date have been unable to  clearly identify the role retinoic acid signaling plays in the intestine. Recent work has  also raised questions about how the important process of retinoic acid biosynthesis is  regulated. This dissertation presents data which clarify some of mechanisms that regulate  retinoic acid biosynthesis in the intestine as well as identify important functions of  retinoic acid signaling in intestinal development and homeostasis.  The data presented herein identify a requirement for axinl in intestinal  differentiation during zebrafish development. In this novel role axinl acts in a Wnt  independent manner to positively regulate the expression of rdhll, a retinol  dehydrogenase. Furthermore we present data which suggest that axinl is able to promote  expression of rdhll by regulating the stability of the transcriptional co-repressor Ctbpl.  In this dissertation we utilize the apc"ur mutant as a model of retinoic acid  deficiency to show that contrary to the currently accepted model, up-regulation of  aldhla2 (raldh2) can be an indication of retinoic acid deficiency rather than an excess.  We also provide direct evidence that retinol dehydrogenases are required in the intestine  for retinoic acid production and signaling. Further, the data presented here provide  genetic evidence that retinoic acid regulates expression of aldhla2 (raldhl) through an indirect negative regulatory loop, and implicates the known stem cell marker pou5fl  (•oct4) as an important positive regulator of aldhla2 (raldh2) expression.  In addition, the data presented in this dissertation clearly identify the essential role  of retinoic acid signaling in establishing intestinal progenitor cell number during  development. These findings also clearly identify an important role for retinoic acid in  maintaining intestinal homeostasis by regulating epithelial differentiation and  proliferation in the adult intestine.  Together the data presented in this dissertation establish retinoic acid as an  essential regulator of intestinal development and homeostasis and identify two pathways  which are important for regulating the biosynthesis of retinoic acid in the intestine.
Sonnenfleckenzeichnung Nr. 22969.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 10.01.1969, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1969

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel