cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Intracellular Drug Delivery: A Route to More Selective and Effective Treatments for Disease
Creators: name: QUYNH NHU MAI
Publisher: name: Monash University
Year: 2019
Subjects: subject: 111504 Pharmaceutical Sciences
subject: FOS: Clinical medicine

description: The Neurokinin 1 receptor (NK1R) is widely expressed in humans and contributes to the regulation of inflammation, gastrointestinal function and pain transmission. Recent research has revealed new relationships between NK1R location and function, and has shown that intracellular NK1R populations are important for driving diseases such as chronic inflammation and pain. We proposed that the efficient and selective delivery of drugs to compartmentalised receptor populations in compartments known as endosomes, will therefore have important implications for drug discovery. This thesis explores novel drug delivery strategies and has demonstrated that drug-lipid modifications and nanoparticles can selectively target the signalling of the NK1R inside cells to improve disease outcomes.
Evaluation of multi-loop multi-scale Feynman integrals for precision physics
Creators: name: Dubovyk, Ievgen
name: Freitas, Ayres
name: Gluza, Janusz
name: Grzanka, Krzysztof
name: Hidding, Martijn
name: Usovitsch, Johann
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Modern particle physics is increasingly becoming a precision science that relies on advanced theoretical predictions for the analysis and interpretation of experimental results. The planned physics program at the LHC and future colliders will require three-loop electroweak and mixed electroweak-QCD corrections to single-particle production and decay processes and two-loop electroweak corrections to pair production processes, all of which are beyond the reach of existing analytical and numerical techniques in their current form. This article presents a new semi-numerical approach based on differential equations with boundary terms specified at Euclidean kinematic points. These Euclidean boundary terms can be computed numerically with high accuracy using sector decomposition or other numerical methods. They are then mapped to the physical kinematic configuration with a series solution of the differential equation system. The method is able to deliver 8 or more digits precision, and it has a built-in mechanism for checking the accuracy of the obtained results. Its efficacy is illustrated with examples for three-loop self-energy and vertex integrals and two-loop box integrals.
Fluorescent Probes for Monitoring Ligand Binding and Receptor Trafficking and Internalisation
Creators: name: JOSHUA WILLIAM CONNER
Publisher: name: Monash University
Year: 2018
Subjects: subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Organic Chemistry

description: The Neurokinin 1 receptor (NK1R) is associated with neurogenic inflammation and nociceptive transmission through signal propagation by the endogenous agonist, substance P. Internalised NK1R in the endosome has a distinct signalling profile from that at the cell surface, resulting in unique pathophysiological outcomes. Therefore, endosomal populations of NK1R may be considered distinct therapeutic targets. The lack of clinical success of current NK1R antagonists, may be due to their inability to target endosomal NK1R. This thesis explores the utility of fluorescent probes for assessing ligand distribution and interaction with endosomal NK1R, and for developing tools to screen for endosomal NK1R ligands.
Código de conducta empresarial en la empresa Representaciones Delsa y Cia Ltda
Creators: name: Sánchez Figueroa, Lisbeth
name: Bermudez Nieto, Beverly
Publisher: name: Universidad de Cartagena
Year: 1996
Subjects: Planificación empresarial
Administración de empresas
Organización de empresa

description: Tesis (Administrador de Empresas).--Universidad de Cartagena. Facultad de Ciencias Económicas. Programa de Administración de Empresas,1996
description: El presente estudio tiene por objeto satisfacer la necesidad que tienen los cartageneros de calzar y vestir bien, ofreciendo todas las lineas de cuero (calzado, bolsos, cinturones, billeteras y demás accesorios), con precios y marcas competitivas en el mercado, prestando un buen servicio con excelente recurso humano. Todo esto para facilitar el crecimiento de la compañía por lo menos en un 30% anual.
El salario
Creators: name: Daza Ramírez, Iván F.
Publisher: name: Universidad de Cartagena
Year: 1979
Subjects: Derecho laboral
Salarios

description: Tesis (Abogado) -- Universidad de Cartagena. Facultad de Derecho y Ciencias Políticas, 1979.
description: Descripción documental y puntual de lo que ha sido el salario en la historia de las relaciones entre trabajadores, empleados, destacando el carácter que hoy tiene como retribución vigilada y protectora, no susceptible de relaciones mezquinas o temarios.
New constraints on the dark matter density profiles of dwarf galaxies from proper motions of globular cluster streams
Creators: name: Malhan, Khyati
name: Valluri, Monica
name: Freese, Katherine
name: Ibata, Rodrigo A.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The central density profiles in dwarf galaxy halos depend strongly on the nature of dark matter. Recently, in Malhan et al. (2021), we employed N-body simulations to show that the cuspy cold dark matter (CDM) subhalos predicted by cosmological simulations can be differentiated from cored subhalos using the properties of accreted globular cluster (GC) streams since these GCs experience tidal stripping within their parent halos prior to accretion onto the Milky Way. We previously found that clusters that are accreted within cuspy subhalos produce streams with larger physical widths and higher dispersions in line-of-sight velocity and angular momentum than streams that are accreted within cored subhalos. Here, we use the same suite of simulations to demonstrate that the dispersion in the tangential velocities of streams ($σ_{v_\mathrm{Tan}}$) is also sensitive to the central DM density profiles of their parent dwarfs and GCs that were accreted from: cuspy subhalos produce streams with larger $σ_{v_\mathrm{Tan}}$ than those accreted inside cored subhalos. Using Gaia EDR3 observations of multiple GC streams we compare their $σ_{v_\mathrm{Tan}}$ values with simulations. The measured $σ_{v_\mathrm{Tan}}$ values are consistent with both an ``in situ'' origin and with accretion inside cored subhalos of $M\sim 10^{8-9}M_{\odot}$ (or very low-mass cuspy subhalos of mass $\sim 10^8M_{\odot}$). Despite the large current uncertainties in $σ_{v_\mathrm{Tan}}$, we find a low probability that any of the progenitor GCs were accreted from cuspy subhalos of $M_{\rm subhalo}\buildrel > \over \sim$ $10^9 M_{\odot}$. The uncertainties on Gaia tangential velocity measurements are expected to decrease in future and will allow for stronger constraints on subhalo DM density profiles.
description: 14 pages, 5 figures, accepted for publication in ApJ Letters
A two-strain reaction-diffusion malaria model with seasonality and vector-bias
Creators: name: Chu, Huijie
name: Bai, Zhenguo
Publisher: name: arXiv
Year: 2022
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics

description: To investigate the combined effects of drug resistance, seasonality and vector-bias, we formulate a periodic two-strain reaction-diffusion model. It is a competitive system for resistant and sensitive strains, but the single-strain subsystem is cooperative. We derive the basic reproduction number $\mathcal {R}_i$ and the invasion reproduction number $\mathcal {\hat{R}}_i$ for strain $i~(i=1,2)$, and establish the transmission dynamics in terms of these four quantities. More precisely, (i) if $\mathcal {R}_1<1$ and $\mathcal{R}_2<1$, then the disease is extinct; (ii) if $\mathcal {R}_1>1>\mathcal{R}_2$ ($\mathcal {R}_2>1>\mathcal{R}_1$), then the sensitive (resistant) strains are persistent, while the resistant (sensitive) strains die out; (iii) if $\mathcal {R}_i>1$ and $\mathcal {\hat{R}}_i>1~(i=1,2)$, then two strains are coexistent and periodic oscillation phenomenon is observed. We also study the asymptotic behavior of the basic reproduction number with respect to small and large diffusion coefficients. Numerically, we demonstrate the phenomena of coexistence and competitive exclusion for two strains and explore the influences of seasonality and vector-bias on disease spreading.
description: 28 pages, 5 figures
Understanding the phase reversals of Galactic cosmic ray anisotropies
Creators: name: Qiao, Bing-Qiang
name: Luo, Qing
name: Yuan, Qiang
name: Guo, Yi-Qing
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The energy spectra and anisotropies are very important probes of the origin of cosmic rays. Recent measurements show that complicated but very interesting structures exist, at similar energies, in both the spectra and energy-dependent anisotropies, indicating a common origin of these structures. Particularly interesting phenomenon is that there is a reversal of the phase of the dipole anisotropies, which challenges a theoretical modeling. In this work, for the first time, we identify that there might be an additional phase reversal at $\sim 100$ GeV energies of the dipole anisotropies as indicated by a few underground muon detectors and the first direct measurement by the Fermi satellite, coincident with the hundreds of GV hardenings of the spectra. We propose that these two phase reversals, together with the energy-evolution of the amplitudes and spectra, can be naturally explained with a nearby source overlapping onto the diffuse background. As a consequence, the spectra and anisotropies can be understood as the scalar and vector components of this model, and the two reversals of the phases characterize just the competition of the cosmic ray streamings between the nearby source and the background. The alignment of the cosmic ray streamings along the local large-scale magnetic field may play an important but sub-dominant role in regulating the cosmic ray propagation. More precise measurements of the anisotropy evolution at both low energies by space detectors and high energies by air shower experiments for individual species will be essential to further test this scenario.
description: 9 pages, 2 figures, accepted by APJ
FCC Based Lepton-Hadron and Photon-Hadron Colliders: Luminosity and Physics
Creators: name: Acar, Y. C.
name: Akay, A. N.
name: Beser, S.
name: Karadeniz, H.
name: Kaya, U.
name: Oner, B. B.
name: Sultansoy, S.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Construction of future electron-positron colliders (or dedicated electron linac) and muon colliders (or dedicated muon ring) tangential to Future Circular Collider (FCC) will give opportunity to utilize highest energy proton and nucleus beams for lepton-hadron and photon-hadron collisions. Luminosity values of FCC based ep, \mup, eA, \muA, \gammap and \gammaA colliders are estimated. Multi-TeV center of mass energy ep colliders based on the FCC and linear colliders (LC) are considered in detail. Parameters of upgraded versions of the FCC proton beam are determined to optimize luminosity of electron-proton collisions keeping beam-beam effects in mind. Numerical calculations are performed using a currently being developed collision point simulator. It is shown that L_{ep}\sim10^{32}\,cm^{-2}s^{-1} can be achieved with LHeC-like upgrade of the FCC parameters.
description: 10 pages, 2 figures, 13 tables. arXiv admin note: text overlap with arXiv:1602.03089
Controlling the Remixing of Separated Dialogue with a Non-Intrusive Quality Estimate
Creators: name: Torcoli, Matteo
name: Paulus, Jouni
name: Kastner, Thorsten
name: Uhle, Christian
Publisher: name: arXiv
Year: 2021
Subjects: subject: Audio and Speech Processing (eess.AS)
subject: Sound (cs.SD)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences

description: Remixing separated audio sources trades off interferer attenuation against the amount of audible deteriorations. This paper proposes a non-intrusive audio quality estimation method for controlling this trade-off in a signal-adaptive manner. The recently proposed 2f-model is adopted as the underlying quality measure, since it has been shown to correlate strongly with basic audio quality in source separation. An alternative operation mode of the measure is proposed, more appropriate when considering material with long inactive periods of the target source. The 2f-model requires the reference target source as an input, but this is not available in many applications. Deep neural networks (DNNs) are trained to estimate the 2f-model intrusively using the reference target (iDNN2f), non-intrusively using the input mix as reference (nDNN2f), and reference-free using only the separated output signal (rDNN2f). It is shown that iDNN2f achieves very strong correlation with the original measure on the test data (Pearson r=0.99), while performance decreases for nDNN2f (r>=0.91) and rDNN2f (r>=0.82). The non-intrusive estimate nDNN2f is mapped to select item-dependent remixing gains with the aim of maximizing the interferer attenuation under a constraint on the minimum quality of the remixed output (e.g., audible but not annoying deteriorations). A listening test shows that this is successfully achieved even with very different selected gains (up to 23 dB difference).
description: Manuscript accepted for the 2021 IEEE Workshop on Applications of Signal Processing to Audio and Acoustics
Targeting sites of lymph-adipose interaction to transform the treatment of immuno-metabolic disease
Creators: name: ENYUAN CAO
Publisher: name: Monash University
Year: 2018
Subjects: subject: 111504 Pharmaceutical Sciences
subject: FOS: Clinical medicine

description: Type 2 diabetes is underpinned by the development of insulin resistance. Insulin resistance is promoted by expansion, inflammation and metabolism changes in abdominal fat. Intestinal lymph flows through the abdominal fat. This thesis demonstrates that the intestinal lymphatic vasculature is highly dynamic, proliferative and leaky in obesity. Lymph leakage into fat causes fat expansion, inflammation and insulin resistance. Modulation of lymph composition through diet modification and inhibition of lymph leakage with medications successfully attenuates the lymphatic remodelling, fat changes and insulin resistance. This thesis suggests that lymph-fat interactions represent a novel treatment target for obesity and type 2 diabetes.
MML is not consistent for Neyman-Scott
Creators: name: Brand, Michael
Publisher: name: arXiv
Year: 2016
Subjects: subject: Machine Learning (stat.ML)
subject: Machine Learning (cs.LG)
subject: Statistics Theory (math.ST)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics
subject: I.2.6
subject: 62G05

description: Strict Minimum Message Length (SMML) is an information-theoretic statistical inference method widely cited (but only with informal arguments) as providing estimations that are consistent for general estimation problems. It is, however, almost invariably intractable to compute, for which reason only approximations of it (known as MML algorithms) are ever used in practice. Using novel techniques that allow for the first time direct, non-approximated analysis of SMML solutions, we investigate the Neyman-Scott estimation problem, an oft-cited showcase for the consistency of MML, and show that even with a natural choice of prior neither SMML nor its popular approximations are consistent for it, thereby providing a counterexample to the general claim. This is the first known explicit construction of an SMML solution for a natural, high-dimensional problem.
description: 16 pages, 0 tables, 0 figures
Assessment Of Warehousing Operation Efficiency And Effectiveness In Logistics Management Practice: The Case Of Berhan Bank S.C
Creators: name: Fetene, Abdi
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2019

description: The study is aimed to make assessment of the warehousing operation efficiency and effectiveness in logistics management practices of Berhan Bank S.C. The study is a descriptive type which utilized quantitative and qualitative data. The researcher organizes face to face approach data collection methodology and. Both primary and secondary data were collected for this study. Primary data were collected with questionnaires and observation and analyzed quantitatively. As the number of employees in the office is below 100, the researcher of the study included the whole population in the study & used census sampling method. A total of 65 questionnaires were distributed to employees, 57 of it were filled and returned. Frequency and percentages were used to analyze the data with the application of SPSS 24 and presented in the table form. The finding of the study showed that the way Birhan bank S.C manages the warehouse operations is approximately good in terms of the five key efficiency and effectiveness indicators. Cost and time indicator of the efficiency and effectiveness shows that, the company should work more on the gaps observed from the study. The quality indicator of the finding indicates that, the company manages the warehouse operation to some extent but there are rooms to improve in some of the areas. However the employee's expectation for productivity indicator is slightly good but the company needs to make an assessment on the employee's basic knowledge and experience on warehouse management and takes necessary actions to improve this part. The warehouse working office seems to be overcrowded and this could affect the employee's productivity in many ways and the company should make any office expansions that can create good environment for the employees. The study discovered that, among the five key efficiency and effectiveness indicators, the Asset management indicator in the company seems to be most valuable and should be given with high emphasis as its current status is poor. In order to achieve significant cost savings from minimized total cost of warehousing operations, the company should give attention to the warehousing function to be cost effective. Improved quality and response time as well improved cost and productivity and improved asset management practice can consequently improve the company warehousing operation efficiency and effectiveness as a whole
Local duality for structured ring spectra
Creators: name: Barthel, Tobias
name: Heard, Drew
name: Valenzuela, Gabriel
Publisher: name: arXiv
Year: 2016
Subjects: subject: Algebraic Topology (math.AT)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics

description: We use the abstract framework constructed in our earlier paper to study local duality for Noetherian $\mathbb{E}_{\infty}$-ring spectra. In particular, we compute the local cohomology of relative dualizing modules for finite morphisms of ring spectra, thereby generalizing the local duality theorem of Benson and Greenlees. We then explain how our results apply to the modular representation theory of compact Lie groups and finite group schemes, which recovers the theory previously developed by Benson, Iyengar, Krause, and Pevtsova.
description: Revised version, to appear in Journal of Pure and Applied Algebra
Optimising the Management of Invasive Fungal Disease in Immunocompromised Patients
Creators: name: WIRAWAN JEONG
Publisher: name: Monash University
Year: 2018
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 111502 Clinical Pharmacology and Therapeutics
subject: FOS: Clinical medicine

description: Infections caused by fungi, also known as, invasive fungal disease (IFD) remains a life threatening complication amongst individuals with reduced immune system. The management of IFD is challenging due to difficulties in establishing early diagnosis and limited treatment options. This thesis has generated critical evidence to optimise the management of IFD in individuals receiving chemotherapy, those undergoing bone marrow transplant, and lung transplant recipients. The contemporary distribution of the causative pathogens, risk factors, treatment and outcomes of IFD are identified. The safety and effectiveness of antifungal medications in preventing this difficult to treat infection is also established.
El rol de las familias en el proceso de rehabilitación de los adolescentes vinculados al Sistema de Responsabilidad Penal, desde las voces de los profesionales de la Defensoría de Familia del SRPA- Centro zonal Montería- Córdoba. Año 2019
Creators: name: Cancio Zabaleta, María Lorena
Publisher: name: Universidad de Cartagena
Year: 2020
Subjects: Trabajo social familiar
Adolescentes - Responsabilidad penal
Abuso de drogas
Comunidad y escuela

description: Tesis (Trabajador Social) -- Universidad de Cartagena. Facultad de ciencias Sociales y Educación, programa de Trabajo Social, 2020
description: En este documento se presenta la investigación titulada “El rol de las familias en el proceso de rehabilitación de los adolescentes vinculados al Sistema de Responsabilidad Penal, desde las voces de los profesionales de la Defensoría de Familia del SRPA- Centro zonal Montería- Córdoba. Año 2020” desde el enfoque cualitativo, para adentrarse en los micro mundos de los adolescentes y tener una relación dialógica no solo con los sujetos, sino con sus realidades, para no pretender explicarlos sino comprenderlos, haciendo uso de la entrevista como método de recolección de información, que fundamentado en el paradigma interpretativo compresivo permite reconocer la subjetividad, el contexto y los saberes propios de cada sujeto y comunidad, desde toda la carga de símbolos que poseen los sujetos y que deben ser reconocidos por el trabajador social, todo esto se pudo lograr a partir de la identificación del contexto, dinámica familiar, los factores de generatividad y vulnerabilidad para proponer acciones desde Trabajo social para el fortalecimiento del rol de la familia en el acompañamiento al proceso de rehabilitación. Es pertinente continuar construyendo proyectos desde el área de la salud, y académica para la atención de esta población, pero además es importante la creación de políticas públicas y sociales que vayan dirigidos a trascender de la atención y solución de necesidades inmediatas, a la potencialización de las habilidades y capacidades, generando reflexiones para que los adolescentes sean agentes de cambio.
Optimization of Richardson extrapolation for quantum error mitigation
Creators: name: Krebsbach, Michael
name: Trauzettel, Björn
name: Calzona, Alessio
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: Quantum error mitigation is a key concept for the development of practical applications based on current noisy intermediate scale quantum (NISQ) devices. One of the most promising methods is Richardson extrapolation to the zero noise limit. While its main idea is rather simple, the full potential of Richardson extrapolation has not been completely uncovered yet. We give an in-depth analysis of the relevant parameters of Richardson extrapolation and propose an optimized protocol for its implementation. This protocol allows for a precise control of the increase in statistical uncertainty and lays the foundation for a significant improvement of the mitigation performance achieved by increasing the number of nodes. Furthermore, we present a novel set of nodes that, on average, outperforms the linear, exponential or Chebyshev nodes frequently used for Richardson extrapolation without requiring any additional resources.
description: 11 pages, 9 figures
Thermodynamics and phase transition in rotational Kiselev black hole
Creators: name: Xu, Zhaoyi
name: Liao, Yi
name: Wang, Jiancheng
Publisher: name: arXiv
Year: 2016
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: In this work, we investigate the thermodynamic properties of rotational Kiselev black holes (KBH). Specifically, we use the first-order approximation of the event horizon (EH) to calculate thermodynamic properties for general equations of state $ω$. These thermodynamic properties include areas, entropies, horizon radii, surface gravities, surface temperatures, Komar energies and irreducible masses at the Cauchy horizon (CH) and EH. We study the products of these thermodynamic quantities, we find that these products are determined by the equation of state $ω$ and strength parameter $α$. In the case of the quintessence matter ($ω=-2/3$), radiation ($ω=1/3$) and dust ($ω=0$), we discuss their properties in detail. We also generalize the Smarr mass formula and Christodoulou-Ruffini mass formula to rotational KBH. Finally we study the phase transition and thermodynamic geometry for rotational KBH with radiation ($ω=1/3$). Through analysis, we find that this phase transition is a second order phase transition. Furthermore, we also obtain the scalar curvature in the thermodynamic geometry framework, indicating that the radiation matter may change the phase transition condition and properties for Kerr black hole.
description: 19pages,2figures
Disease-oriented image embedding with pseudo-scanner standardization for content-based image retrieval on 3D brain MRI
Creators: name: Arai, Hayato
name: Onga, Yuto
name: Ikuta, Kumpei
name: Chayama, Yusuke
name: Iyatomi, Hitoshi
name: Oishi, Kenichi
Publisher: name: arXiv
Year: 2021
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: To build a robust and practical content-based image retrieval (CBIR) system that is applicable to a clinical brain MRI database, we propose a new framework -- Disease-oriented image embedding with pseudo-scanner standardization (DI-PSS) -- that consists of two core techniques, data harmonization and a dimension reduction algorithm. Our DI-PSS uses skull stripping and CycleGAN-based image transformations that map to a standard brain followed by transformation into a brain image taken with a given reference scanner. Then, our 3D convolutioinal autoencoders (3D-CAE) with deep metric learning acquires a low-dimensional embedding that better reflects the characteristics of the disease. The effectiveness of our proposed framework was tested on the T1-weighted MRIs selected from the Alzheimer's Disease Neuroimaging Initiative and the Parkinson's Progression Markers Initiative. We confirmed that our PSS greatly reduced the variability of low-dimensional embeddings caused by different scanner and datasets. Compared with the baseline condition, our PSS reduced the variability in the distance from Alzheimer's disease (AD) to clinically normal (CN) and Parkinson disease (PD) cases by 15.8-22.6% and 18.0-29.9%, respectively. These properties allow DI-PSS to generate lower dimensional representations that are more amenable to disease classification. In AD and CN classification experiments based on spectral clustering, PSS improved the average accuracy and macro-F1 by 6.2% and 10.7%, respectively. Given the potential of the DI-PSS for harmonizing images scanned by MRI scanners that were not used to scan the training data, we expect that the DI-PSS is suitable for application to a large number of legacy MRIs scanned in heterogeneous environments.
description: 13 pages, 7 figures
BPS Invariants for a Knot in Seifert Manifolds
Creators: name: Chung, Hee-Joong
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: Geometric Topology (math.GT)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We calculate homological blocks for a knot in Seifert manifolds when the gauge group is $SU(N)$. We obtain the homological blocks with a given representation of the gauge group from the expectation value of the Wilson loop operator by analytically continuing the Chern-Simons level. We also obtain homological blocks with the analytically continued level and representation for a knot in the Seifert integer homology spheres.
description: 26 pages, v2 minor revisions; v3 minor revisions, published version
"Identification and validation of miRNAs that downregulate expression of the tumor suppressor protein Semaphorin 5A in human glioblastomas"
Creators: name: AMRUTHA MENON
Publisher: name: Monash University
Year: 2018
Subjects: subject: 111201 Cancer Cell Biology
subject: FOS: Clinical medicine
subject: Cell Biology
subject: Molecular Biology

description: Glioblastomas are malignant and common form of brain tumors that exhibit high invasiveness and resistance to chemo/radiotherapy, leading to high recurrence and short patient survival. We demonstrated tumor suppressor functions of Sema5A protein in inhibiting glioblastoma cell invasion and proliferation, which is compromised in high-grade tumors due to its downregulation. Nonetheless, neither changes in transcription level nor mutations and genetic aberrations was found in Sema5A. In this study, several miRNAs were identified by in silico predication and experimentally validated to repress translation of Sema5A, which account for the significantly reduced expression of Sema5A in glioblastomas and represent novel therapeutics targets.
Praktische Probleme bei der Konstruktion von Software zur automatisierten Terminierungsanalyse
Creators: name: Schultze, Jan
Publisher: name: Technische Universität Dortmund
Year: 2014
Subjects: subject: Terminierungsanalyse imperativer Programmiersprachen
subject: Transformation imperativer Programme zu funktionalen Programmen
subject: Umsortieren von Anweisungen
subject: Semantische Äquivalenz von Permutationen von Anweisungen
subject: Operationelle Semantik von Ein- und Ausgabeanweisungen
subject: 004

description: Die Arbeit beschäftigt sich mit den Einsatzmöglichkeiten bereits bestehender automatisierter Verfahren zur Terminierungsanalyse für die Klasse der praktische relevanten, imperativen Programmiersprachen. Die automatisierte Terminierungsanalyse ist für Termersetzungssysteme besonders gut untersucht. Eine Anwendung der resultierenden Methoden ist für deklarative Programmiersprachen mit beachtlichem Erfolg möglich, während sich eine Anwendung auf imperative Sprachen schwieriger gestaltet. Jedoch können durch Ausnutzung der großen Ausdrucksstärke funktionaler Programmiersprachen imperative Programme durch funktionale Programme simulieren. Es wird untersucht, inwiefern die resultierenden funktionalen Programme der Terminierungsanalyse mit Termersetzungsmethoden zugänglich sind. Es werden verschiedene Probleme gezeigt, die durch Anwendung bestimmter Programmtransformationen gelöst werden können, sodass arithmetische Teilprogramme einer Terminierungsanalyse zugänglich werden. Es wird auch gezeigt, dass dieser Ansatz nicht zur Analyse von Programmen, die dynamisch Speicher allozieren genutzt werden kann. Ein weiteres Problem bei der Analyse praktisch relevanter, imperativer Sprachen aus der Praxis stellen Ein- und Ausgabeanweisungen dar. Da diese den bestehenden Verfahren unzugänglich sind, sind im Allgemeinen Transformationen notwendig, um zumindest Teilprogramme zu analysieren. Es wird daher eine formale Semantik für eine imperative Sprache mit Ein- und Ausgabeanweisung eingeführt. Auf dieser Grundlage wird ein Kriterium entwickelt, welches erlaubt, die semantische Äquivalenz einer Permutation einer Anweisungsfolge nachzuweisen.
The Role of Monitoring & Evaluation on Performance of Public Organization Projects in Ethiopia: A Case of Ethiopian Public Health Institution
Creators: name: Muluye, Samuel
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2018

description: Project management is very relevant to establish project controlling system to ensure that the projects perform towards the success of the project objectives. Monitoring and evaluation can help an organization extract relevant information from past and ongoing activities that can be used as the basis for project planning, performance monitoring and evaluation. Most of public organization doesn't have effective and efficient Monitoring and Evaluation system to accomplish the project activities within the planned budget, scheduled time and required quality. The main objective of the research is to assess the role of Monitoring and Evaluation on the performance of the public organization projects in Ethiopia. The study employed a descriptive survey and targeted 345 scientific staffs who have used Monitoring and Evaluation system for designing, planning and implementing of different EPHI's projects. A sample of 78 employees were selected using stratified sampling techniques and data were collected from the project managers, team leaders and project staffs using self-administered questionnaire. Data were analyzed using regression and correlation analysis to establish the relationship between the variables. The finding showed that all independent variables such as M&E human resource, M&E implementation strategies, M&E training and management support for M&E have a significant and positive effect on the performance of projects in Ethiopian Public Health Institution(EPHI). The study recommends that EPHI should hire sufficient staffs who have M&E technical skills for projects and assess the performance and competences of staffs regularly. Good M&E system should be established and revised based on the objectives of the projects. The project managers should be committed and provide high emphasis for designing and implementing of M&E related activities. The project managers and team leaders should be ensured all staffs have required technical skill to perform M&E activities and regularly provided tailored M&E training
The critical O(N) CFT: Methods and conformal data
Creators: name: Henriksson, Johan
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: The critical $O(N)$ CFT in spacetime dimensions $2 < d < 4$ is one of the most important examples of a conformal field theory, with the Ising CFT at $N=1$, $2 \leq d < 4$, as a notable special case. Apart from numerous physical applications, it serves frequently as a concrete testing ground for new approaches and techniques based on conformal symmetry. In the perturbative limits - the $4-\varepsilon$ expansion, the large $N$ expansion and the $2+\tildeε$ expansion - a lot of conformal data have been computed over the years. In this report, we give an overview of the critical $O(N)$ CFT, including some methods to study it, and present a large collection of conformal data. The data, extracted from the literature and supplemented by many additional computations of order $\varepsilon$ anomalous dimensions, are made available through an ancillary data file.
description: 88+13 pages, many tables, one ancillary data file. v2. Revised version, ancillary data file updated. v3. References updated, typos corrected
Eigenvalues behaviours for self-adjoint Pauli operators with unsigned perturbations and admissible magnetic fields
Creators: name: Sambou, Diomba
name: Taarabt, Amal
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mathematical Physics (math-ph)
subject: Spectral Theory (math.SP)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We investigate the behaviour of the eigenvalues of two-dimensional Pauli operators with nonconstant magnetic fields perturbed by a sign-indefinite decaying electric potential V. We prove new eigenvalues asymptotics.
description: Final published version
Informe de la práctica de administración de los servicios de enfermería en el Hospital Regional Rosario Pumarejo de López
Creators: name: Galvan L., Cenelia
name: Peña De La, Olinda
Publisher: name: Universidad de Cartagena
Year: 1975
Subjects: Sevicios de enferrmeria
Area hospitalaria
Area ambulatoria

description: Tesis (Enfermero) -- Universidad de Cartagena, Facultad de Enfermería.1975
description: Este trabajo de investigación tiene el propósito de presentar,en este informe de la práctica de administración de los servicios de enfermería en el hospital Rosario Pumarejo de López se propone dar a conocer la situación de enfermería en el hospital y su posible causa. El plan de trabajo trazado, programas y actividades realizadas con sus limitaciones
Anomalous Elastic Response of Silicon to Uniaxial Shock Compression on Nanosecond Time Scales
Creators: name: Allen, A.
name: Belak, J.
name: Boehly, T.
name: Hauer, A.
name: Holian, B.
name: Kalantar, D.
name: Kyrala, G.
name: Lee, R. W.
name: Lomdahl, P.
name: Loveridge-Smith, A.
name: Meyers, M. A.
name: Paisley, D.
name: Pollaine, S.
name: Remington, B.
name: Swift, D. C.
Publisher: name: The American Physical Society
Year: 2001
Subjects: subject: 530

description: Physical Review Letters
Creating the Radius Gap without Mass Loss
Creators: name: Lee, Eve J.
name: Karalis, Amalia
name: Thorngren, Daniel P.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The observed exoplanet population features a gap in the radius distribution that separates the smaller super-Earths ($\lesssim$1.7 Earth radii) from the larger sub-Neptunes ($\sim$1.7--4 Earth radii). While mass loss theories can explain many of the observed features of this radius valley, it is difficult to reconcile them with potentially rising population of terrestrials beyond orbital periods of $\sim$30 days. We investigate the ability of gas accretion during the gas-poor phase of disk evolution to reproduce both the location of the observed radius gap and the existence of long-period terrestrial planets. Updating the analytic scaling relations of gas accretion rate accounting for the shrinking of the bound radius by hydrodynamic effects and deriving a more realistic disk temperature profile, we find that the late-stage gas accretion alone is able to carve out the observed radius gap, with slopes $R_{\rm gap} \propto P^{-0.096}$ and $R_{\rm gap} \propto M_\star^{0.15}$ for top-heavy; and $R_{\rm gap} \propto P^{-0.089}$ and $R_{\rm gap} \propto M_\star^{0.22}$ for bottom-heavy core mass distributions, in good agreement with observations. The general morphology of the primordial radius gap is stable against a range of disk gas density and disk accretion rate with the latter affecting mostly the population of large planets ($\gtrsim$3--4$R_\oplus$). The peaks and valleys in the radius distribution were likely set in place primordially while post-formation mass loss further tunes the exoplanetary population. We provide potential observational tests that may be possible with TESS, PLATO and Roman Space Telescope.
description: ApJ in press
Orphan G Protein-Coupled Receptor (GPCR) mediated regulation of metabolic inflammation
Creators: name: DARREN MARK RIDDY
Publisher: name: Monash University
Year: 2018
Subjects: subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: Pharmacology

description: Over 400 million people worldwide are diagnosed with type 2 diabetes mellitus (T2DM). This disease occurs due to both genetic and lifestyle factors. Infiltration of immune cells into tissues produces chronic low-grade inflammation and plays a key role in the development and progression of the disease. Deletion of the orphan G protein-coupled receptor, GPR21, reduced the migration of isolated human and mouse monocytes and improved the insulin sensitivity of mice. Identification a selective GPR21 agonist allowed characterisation of the potential signalling mechanism involved. These findings provide support that GPR21 is a suitable drug target for the treatment of metabolic inflammation.
Análisis del impacto pedagógico en el uso de Red´s diseñados con la herramienta exelearning para el fortalecimiento de la comprensión lectora de los estudiantes del grado cuarto B de la sede dos de la Institución Educativa Distrital Jesús Misericordioso de Barranquilla
Creators: name: Pérez Olivera, Heidy María
name: Vergara Ledesma, Cindy Lorena
name: Vargas Torres, Adonis De Jesús
Publisher: name: Universidad de Cartagena
Year: 2022
Subjects: subject: Tecnología educativa
subject: Enseñanza con ayuda de computadores
subject: Educación primaria
subject: Comprensión de lectura - Enseñanza

description: La innegable trasformación de las prácticas educativas ha traído consigo cambios importantes en lo que tiene que ver con las condiciones en las que se llevan a cabo los procesos de enseñanza aprendizaje, por ende, la innovación en los procesos educativos es necesaria. Ante la necesidad de mejorar los procesos de comprensión de lectura se presenta en la presente investigación. Esta propuesta investigativa tiene como objetivo analizar el impacto pedagógico que tiene el uso de dichos recursos para el fortalecimiento de la comprensión lectora de los estudiantes. Lo anterior se realizará a partir de la ejecución de actividades diseñadas con la herramienta exelearning y reconociendo la importancia de desarrollar competencias en cuanto a la comprensión lectora para mejorar los procesos académicos de los educandos. Con este fin la pregunta de investigación es la siguiente: ¿Cuál es el impacto pedagógico generado por el uso de Red diseñados con la herramienta exelearning para el fortalecimiento de la comprensión lectora de los estudiantes del grado cuarto B de la sede dos de la Institución Educativa Distrital Jesús Misericordioso de la ciudad de Barranquilla – Atlántico?. Esta propuesta tiene como antecedentes que la fundamentan algunos análisis hechos por educadores los cuales reafirman la gran incidencia que tiene la implementación de recursos educativos en el quehacer pedagógico específicamente en el área de comprensión lectora.
description: Introducción 12; Planteamiento y formulación del problema 15; Planteamiento 15; Formulación 21;Antecedentes 21; Justificación 30 Objetivo general 32 Objetivos específicos 32 Supuestos y constructos 33 Alcances y Limitaciones 35 Marco de Referencia 36 Contextual 36 Normativo 38 Teórico 41 Conceptual 46 Metodología 51 Tipo de Investigación 51 Modelo de Investigación 52 Fases del Modelo 53 Población y muestra 53 Categorías de estudio 56 Técnicas e instrumentos de recolección de datos 57 Ruta de Investigación 62 Técnicas de análisis de la información 62 Intervención Pedagógica o Innovación TIC, institucional u otra 64 Análisis, Conclusiones y Recomendaciones 89 Referencias Bibliográficas121 Anexos 129
title: Higher levels of acute axonal injury in the spinal normal-appearing white matter in multiple sclerosis than neuromyelitis optica
Creators: name: Wegner, Christiane
name: Swiniarski, Agnes
name: Ott, Martina
name: Stadelmann, Christine
name: Brück, Wolfgang
Publisher: name: German Medical Science GMS Publishing House
Year: 2015
Subjects: subject: 610 Medical sciences; Medicine

description: Background: Multiple sclerosis (MS) and neuromyelitis optica (NMO) display inflammatory demyelinating lesions in the spinal cord, brain and optic nerve. In contrast to relative clinical stability between relapses in NMO, MS patients typically accumulate disability independently of relapses during the[for full text, please go to the a.m. URL]
description: 60th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN)
New binary self-dual codes of lengths 56, 62, 78, 92 and 94 from a bordered construction
Creators: name: Gildea, Joe
name: Korban, Adrian
name: Roberts, Adam Michael
name: Tylyshchak, Alexander
Publisher: name: arXiv
Year: 2021
Subjects: subject: Information Theory (cs.IT)
subject: Combinatorics (math.CO)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics
subject: 94B05, 15B10, 15B33

description: In this paper, we present a new bordered construction for self-dual codes which employs $λ$-circulant matrices. We give the necessary conditions for our construction to produce self-dual codes over a finite commutative Frobenius ring of characteristic 2. Moreover, using our bordered construction together with the well-known building-up and neighbour methods, we construct many binary self-dual codes of lengths 56, 62, 78, 92 and 94 with parameters in their weight enumerators that were not known in the literature before.
description: corrected typos; other minor corrections. arXiv admin note: substantial text overlap with arXiv:2102.10354, arXiv:2106.12355, arXiv:2102.12326
Proyecto protección de tierras y patrimonio de la población desplazada
Creators: name: Morales Doria, Amira Teresa
Publisher: name: Universidad de Cartagena
Year: 2006
Subjects: Población desplazamiento - Colombia

description: Tesis (Trabajadora Social) -- Universidad de Cartagena. Facultad de Ciencias Sociales y Educación. Programa de Trabajo Social, 2006
description: Informe sistematizado sobre el proyecto de intervención, el contexto en el que se desarrolla la metodología por el equipo de trabajo, mostrando con el tema “Tierra” todo sobre las poblaciones desplazadas y sus casos.
The Practices and Challenges of the Public Private Partnership (PPP) based Project Implementation. The case of "Lehulu" Project
Creators: name: Bekele, Samuel
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2018

description: This project paper focused on assessing the practices and challenges of the Public Private Partnership (PPP) based project implementation from the private partner's perspective. To this end it used the case of "Lehulu". "Lehulu" was a PPP project implemented through a collaboration of the public partner MCIT and the private partner KFT to improve utility bill collection system of the three publicly owned utility companies. The main objective of the paper was to explore the project organization and PM practice employed in the project along with its effects on cost, time and quality. Besides, the major factors attributed for the project success and the major challenges faced in the course of the project implementation were identified. To achieve its objective, the study employed a mixed research approach that used both qualitative and quantitative data and data analysis method. Accordingly, questioners and structured interviews were administered among 34 technical staff and two officials of the KFT, who have been involved in the project implementation, respectively. Then the resulting information was analyzed using descriptive statistics. In addition to the primary data collected in the mentioned manner, secondary data were collected through review of relevant project documents such as project plan, project reports, etc. and presented through describing the facts of the project. Accordingly, the revision of the project documents and interview input revealed that the project was organized and managed through a consortium formed among three partners KFT, Wipro and TATA consultancy groups. The reason for this form of PM organization and practice was the local private partners' lack of technological ability, PM capacity and the existence of the knowledge gap about the PPP modality among both the public and the private partners. The overall effect of this practice was a moderate delay in project time, favorable cost performance and meeting the quality requirement of the project. The quantitative data analysis substantiated with the interview input attributed the main success factor for the project success was KFT's capabilities of fulfilling the contract while the major challenge was poor banking policies and unavailability of loans to fund such projects as PPP.