cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Taxonomy, Phylogeny and Genomics of the Wallemiomycetes and a Newly Discovered Class of Extremophilic Fungi
Creators: name: Nguyen, Hai
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Wallemiomycetes
Fungi
Geminibasidiomycetes
Fungal Taxonomy

description: New species of fungi that belong to the class Wallemiomycetes and related lineages were discovered and characterized. The Wallemiomycetes includes species of brown moulds from the genus Wallemia. Further study was warranted for Wallemia sebi because of its ubiquity in the human indoor environments and its potential roles in food spoilage, human allergy and disease. A survey of Wallemia in house dust was conducted. Sequencing of DNA and application of the genealogical concordance phylogenetic species recognition (GCPSR) led to recognition of four species within the W. sebi species complex (WSSC) and served as the foundation for phenotypic assessment and the formal description of three new species called W. mellicola, W. canadensis and W. tropicalis. A survey of heat resistant fungi in soils coincidentally resulted in the discovery of a new lineage of fungi related to Wallemia. This new lineage included a previously described monotypic genus Basidioascus and a new sister genus given the name Geminibasidium. A part of the morphological life cycle of these fungi was documented where two new basidial types were discovered, followed by the description of three new species called B. magus, G. donsium and G. hirsutum. Further studies on the sexuality and origins of the species B. undulatus were carried out with genome sequencing, genome analysis, confocal microscopy and electron microscopy. These results led to the creation of a new class of fungi called the Geminibasidiomycetes, which are distantly related to the Wallemiomycetes. Solving the WSSC, circumscribing a new class of fungi called Geminibasidiomycetes and characterizing the species of Geminibasidiomycetes on a taxonomic and genomic level are my original contributions to scientific knowledge.
Intramolecular Cope-type Hydroamination of Alkenes and Alkynes Using Hydrazides
Creators: name: Hunt, Ashley D.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: hydroamination
hydrazide
azomethine imine
alkene
alkyne
dipole
heterocycles

description: Nitrogen-containing molecules are ubiquitous in both natural products and pharmaceutical drugs, thus an efficient method for the formation of these motifs is of great importance. Hydroamination, that is the addition of an N-H bond across an unsaturated carbon-carbon bond of an alkene or alkyne, stands out as a potential approach to obtain such molecules. To date, most research in this area relies on transition-metal catalysis to enable such reactivity. In efforts directed towards metal-free alternatives, we have developed a simple, metal-free hydroamination of alkenes using hydrazides. Further investigation into the corresponding reactivity of alkynes with hydrazides has provided access to novel azomethine imine products. In Chapter 2, expansion of the substrate scope with respect to the intramolecular hydroamination of alkenes using hydrazides, as well as studies directed towards elucidation of the mechanism of this reaction will be presented. The intramolecular hydroamination of alkynes using hydrazides and methods to access and isolate the azomethine imine products formed will be discussed in Chapter 3.
ICT incubation in Malaysia: selection performance practice
Creators: name: Khalid, Fararishah Abdul
name: Gilbert, David
name: Huq, Afreen
Publisher: name: Swinburne
Year: 2024

description: The role of business incubators has gained recognition in both developed and developing nations. Positive outcomes of business incubators include the creation of jobs, acceleration in growth of new businesses, and revitalization of communities. This paper analyzes the strategies used by Malaysian ICT incubators in selecting prospective incubatees. A total of 118 incubatees participated in this study through a survey questionnaire and were asked about the selection process they were subjected to during their application. Exploratory factor analysis reveals that ICT incubators in Malaysia largely tend to select their incubatees based on the market characteristics that the incubatees plan to get into. Other selection criteria used product characteristics and financial characteristics of the incubatees applying.
Supplementary document for Machine learning for real-time optical property recovery in interstitial photodynamic therapy – A simulation-based study - 5356662.pdf
Creators: name: Yassine, Abdul-Amir
name: Lilge, Lothar
name: Betz, Vaughn
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Uncategorized

description: Supplemental document to the manuscript
O amor virtual como instância de empreendedorismo e de reificação
Creators: name: Castro, Julio Cesar Lemes De
Publisher: name: figshare
Year: 2016
Subjects: subject: 200104 Media Studies
subject: FOS: Media and communications
subject: Philosophy
subject: FOS: Philosophy, ethics and religion

description: Several fronts in contemporary society show an appreciation of entrepreneurship, in the sense of an apparent strengthening of the subjective agency. The counterpart of this is a movement of reification, which relies on the engagement of the subject himself. These trends, which are also present in cyberculture in general, are illustrated by the phenomenon of virtual love: the multiplication of dating options and, in theory, the decline of standardized external models gives the individual more possibilities for taking the initiative, counterbalanced by the propensity for objectification of himself and the other. / Na sociedade contemporânea, observa-se em várias frentes uma valorização do empreendedorismo, no sentido de um aparente fortalecimento da agência subjetiva. A contrapartida disso é um movimento de reificação, que conta com o engajamento do próprio sujeito. Essas tendências, também presentes na cibercultura de modo geral, são ilustradas pelo fenômeno do amor virtual: a multiplicação de opções amorosas e o declínio de modelos externos padronizados dão, em tese, a cada um a possibilidade de maior iniciativa, contrabalançada pela propensão a objetivar-se e objetivar o outro.
Integrated Approach to Assess Supply Chains: A Comparison to the Process Control at the Firm Level
Creators: name: (:Unkn) Unknown
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: Supply Chain Management
Partial Least Squares
Integrated Supply Chain Approach

description: This study considers whether or not optimizing process metrics and settings across a supply chain gives significantly different outcomes than consideration at a firm level. While, the importance of supply chain integration has been shown in areas such as inventory management, this study appears to be the first empirical test for optimizing process settings. A Partial Least Squares (PLS) procedure is used to determine the crucial components and indicators that make up each component in a supply chain system. PLS allows supply chain members to have a greater understanding of critical coordination components in a given supply chain. Results and implications give an indication of what performance is possible with supply chain optimization versus local optimization on simulated and manufacturing data. It was found that pursuing an integrated approach over a traditional independent approach provides an improvement of 2% to 49% in predictive power for the supply chain under study.
An investigation into posttraumatic stress and posttraumatic growth among trauma reporting Australian journalists
Creators: name: McMahon, Catherine Margaret
Publisher: name: Swinburne
Year: 2024

description: Research into the impact of psychological trauma exposure such as violence and disasters on Australian journalists and other media professionals. The research used both statistical methods and interviews to examine posttraumatic stress and posttraumatic growth outcomes. The thesis provides empirical support that posttraumatic growth is present amongst trauma-reporting journalists as a general group, and more specifically in camera operators, war reporters, and freelance journalists. The results point to the importance of understanding that posttraumatic experiences are complex and multifaceted, and can include rich life changes of growth post trauma, as well as negative posttraumatic stress impacts.
An Interactive Debugger for Rust Trait Errors
Creators: name: Gray, Gavin
name: Crichton, Will
name: Krishnamurthi, Shriram
Publisher: name: arXiv
Year: 2025
Subjects: subject: Programming Languages (cs.PL)
subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: Compiler diagnostics for type inference failures are notoriously bad, and type classes only make the problem worse. By introducing a complex search process during inference, type classes can lead to wholly inscrutable or useless errors. We describe a system, Argus, for interactively visualizing type class inferences to help programmers debug inference failures, applied specifically to Rust's trait system. The core insight of Argus is to avoid the traditional model of compiler diagnostics as one-size-fits-all, instead providing the programmer with different views on the search tree corresponding to different debugging goals. Argus carefully uses defaults to improve debugging productivity, including interface design (e.g., not showing full paths of types by default) and heuristics (e.g., sorting obligations based on the expected complexity of fixing them). We evaluated Argus in a user study where $N = 25$ participants debugged type inference failures in realistic Rust programs, finding that participants using Argus correctly localized $2.2\times$ as many faults and localized $3.3\times$ faster compared to not using Argus.
Creating digital divas: scaffolding perception change through secondary school and university alliances
Creators: name: Lang, Catherine
name: Craig, Annemieke
name: Fisher, Julie
name: Forgasz, Helen
Publisher: name: Swinburne
Year: 2024

description: Over the last 20 years much has been done to encourage female students to choose computing courses and computing careers. Some instances of positive effects have been reported, yet the proportional disparity in gender in this discipline continues to grow. This paper reports on a program called 'Digital Divas'. Digital Divas aims to scaffold positive perceptions around computing in the early years of secondary school by involving female students in upbeat computing experiences over a semester. It introduces university undergraduates to the secondary classroom to provide informal role models and mentors, as well as interactions with young computing professionals. This classroom environment enables computer applications to be more strongly linked with future careers. The commitment to a semester length unit was influential in changing perceptions about girls and computing, and the program was supported by the wider school community. We posit that this type of curriculum intervention is needed and has the potential to build technical human capital in female students.
Understanding the Role of the Ottawa Ankle Rules in Physicians' Radiography Decisions: A Social Judgment Analysis Approach
Creators: name: Syrowatka, Ania
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: Evidence-Based Medicine
Knowledge Translation
Clinical Decision Rules
Ottawa Ankle Rules
Social Judgment Analysis
Brunswik Lens Model
Clinical Judgment Survey

description: Clinical decision rules improve health care fidelity, benefit patients, physicians and healthcare systems, without reducing patient safety or satisfaction, while promoting cost-effective practice standards. It is critical to appropriately and consistently apply clinical decision rules to realize these benefits. The objective of this thesis was to understand how physicians use the Ottawa Ankle Rules to guide radiography decision-making. The study employed a clinical judgment survey targeting members of the Canadian Association of Emergency Physicians. Statistical analyses were informed by the Brunswik Lens Model and Social Judgment Analysis. Physicians’ overall agreement with the ankle rule was high, but can be improved. Physicians placed greatest value on rule-based cues, while considering non-rule-based cues as moderately important. There is room to improve physician agreement with the ankle rule and use of rule-based cues through knowledge translation interventions. Further development of this Lens Modeling technique could lend itself to a valuable cognitive behavioral intervention.
Supplementary document for Robust functional imaging of taste sensation with Bessel beam - 5358507.pdf
Creators: name: Han, Jisoo
name: Kim, Seonghoon
name: Choi, Pyonggang
name: Lee, Sungho
name: Jo, Yongjae
name: KIM, Eunsoo
name: Choi, Myunghwan
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary Fig. 1
A unified approach to selecting optimal step lengths for adaptive vector quantizers
Creators: name: Andrew, Lachlan L. H.
name: Palaniswami, Marimuthu
Publisher: name: Swinburne
Year: 2024

description: This paper presents expressions for the optimal step length to use when training a vector quantizer by stochastic approximation. By treating each update as an estimation problem it provides a unified framework covering both batch and incremental training which were previously treated separately and extends existing results to the semibatch case. In addition the new results presented here provide a measurable improvement over results which were previously thought to be optimal.
Supporting Interdisciplinary Healthcare Team Dynamics with Business Process Management
Creators: name: Catal, Nihan
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Business Process Management
Healthcare Teams
Team Dynamics
Workflow
Interface
GESI
Interdisciplinary Healthcare Teams
BPM Suite
IHT
BPMS

description: [Context] Interdisciplinary healthcare teams (IHTs) include practitioners from different disciplines who collaborate for providing care to patients. IHTs often follow clinical workflows composed of tasks that must be executed by practitioners with specific capabilities. The membership in an IHT can however evolve over time for a given patient. [Problem] Existing Business Process Management (BPM) suites and their workflow execution engines are designed for supporting and monitoring general workflows, but they are insufficient in supporting the allocation of tasks to the most suitable practitioners during the execution of healthcare workflows in a dynamic context. [Methodology] Using Design Science Research, this thesis builds on top of an existing semantic layer, which includes an ontology defining IHT team concepts and relationships that are used to reason automatically about team dynamics, in order to add dynamic team management to BPM suites. It does so by proposing and designing middleware (including a generic interface) that enables the semantic layer to command the BPM suite to allocate suitable practitioners to tasks during the execution of clinical workflows. The design and implementation of this middleware are discussed, and the latter is tested on a commercial BPM suite for two realistic clinical processes. [Results] The proof-of-concept implementation demonstrates the feasibility of using middleware with a generic interface to add support for IHT executing BPM suite when managing a patient. In addition, the thesis also demonstrates that the ontology used in the semantic layer is minimal, that is, all of its concepts and relationships are necessary for the required team functionalities (usually absent from BPM tools) to work properly.
Langue et discours dans la littérature régionaliste au début du XXe siècle au Pays de Caux: les Terreux de Gaston Demongé
Creators: name: Lefrançois, Hélène
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Les Terreux
Gaston Demongé
Littérature orale
Pays de Caux
La Belle Époque
Littérature régionaliste
Patois cauchois
Sociolingusitique
Discours et langage
Dialectes
Contes populaires
La Troisième République
Linguistique
Paysans et littérature

description: En France, le XIXe siècle est témoin d’un renouveau de la littérature orale. Alors que les dialectologues accomplissent un important travail de documentation et de préservation des sources orales au XIXe siècle, les littéraires mettent en scène les patois. Les contes populaires de Gaston Demongé, auteur normand (Aux gars de Normandie, 1917 ; Les Terreux, 1925 et 1955) ont marqué l’imaginaire de son époque. Auteur engagé dans le débat sociopolitique sous la Troisième République, Gaston Demongé opte par son choix de retranscription du patois de rester fidèle à ses convictions profondément régionalistes. L’œuvre de l’auteur normand offre une disparité dans sa façon d’aborder le patois cauchois et le discours social qu’il transmet sur le paysan entre le début du XXe siècle et la période de l’après guerre. De fait, il manifeste dans son écriture, dès 1925, son désaccord avec le discours imposé sur le paysan et son langage.
Suppression of human peripheral blood mononuclear cell response to mitogen by tetanus toxoid. A study of the possible mechanisms.
Creators: name: Stefanovic, Helen.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Biology, Microbiology.

description: Previous studies have shown that certain antigens can down-regulate immune responses of human peripheral blood mononuclear cells (PBMC) both in vivo and in vitro. This study demonstrates that tetanus toxoid (TT), in a dose-dependent fashion, suppresses the induction of a blastogenic response of PBMC by phytohemagglutinin (PHA), monoclonal anti-CD3, and anti-CD4 antibody. Pokeweed mitogen (PWM)-induction of IgG and IgM is suppressed as well. The suppression is partially reversed by indomethacin and IL-2, but not by IL-1 or tumor necrosis factor (TNF-$\alpha$). PBMC pre-incubated with TT could suppress the PHA blastogenic response of fresh autologous cells during co-incubation. The removal of CD4$\sp+$ cells prior to induction of suppression greatly diminished the suppression of PHA blastogenic response, whereas the elimination of CD8$\sp+$ cells had no effect. Therefore it is concluded that TT induces non-specific suppressor cells that can strongly dampen mitogenic responses, and that CD4$\sp+$ cells plays an important role in this suppression. CD4 $\sp+$ cell, together with monocytes, may suppress mitogenic responses involving a prostaglandin-dependent pathway.
Development of a consensus statement on the role of the family in the physical activity, sedentary, and sleep behaviours of children and youth
Creators: name: Rhodes, Ryan E.
name: Guerrero, Michelle D.
name: Vanderloo, Leigh M.
name: Barbeau, Kheana
name: Birken, Catherine S.
name: Chaput, Jean-Philippe
name: Faulkner, Guy E. J., 1970-
name: Janssen, Ian
name: Madigan, Sheri
name: Mâsse, Louise C.
name: McHugh, Tara-Leigh
name: Perdew, Megan
name: Stone, Kelly
name: Shelley, Jacob
name: Spinks, Nora
name: Tamminen, Katherine A.
name: Tomasone, Jennifer R.
name: Ward, Helen
name: Welsh, Frank
name: Tremblay, Mark S.
Publisher: name: BioMed Central
Year: 2020

description: Background: Children and youth who meet the physical activity, sedentary, and sleep behaviour recommendations in the Canadian 24-Hour Movement Guidelines are more likely to have desirable physical and psychosocial health outcomes. Yet, few children and youth actually meet the recommendations. The family is a key source of influence that can affect lifestyle behaviours. The purpose of this paper is to describe the process used to develop the Consensus Statement on the Role of the Family in the Physical Activity, Sedentary, and Sleep Behaviours of Children and Youth (0–17 years) and present, explain, substantiate, and discuss the final Consensus Statement. Methods: The development of the Consensus Statement included the establishment of a multidisciplinary Expert Panel, completion of six reviews (three literature, two scoping, one systematic review of reviews), custom data analyses of Statistics Canada’s Canadian Health Measures Survey, integration of related research identified by Expert Panel members, a stakeholder consultation, establishment of consensus, and the development of a media, public relations, communications and launch plan. Results: Evidence from the literature reviews provided substantial support for the importance of family on children’s movement behaviours and highlighted the importance of inclusion of the entire family system as a source of influence and promotion of healthy child and youth movement behaviours. The Expert Panel incorporated the collective evidence from all reviews, the custom analyses, other related research identified, and stakeholder survey feedback, to develop a conceptual model and arrive at the Consensus Statement: Families can support children and youth in achieving healthy physical activity, sedentary and sleep behaviours by encouraging, facilitating, modelling, setting expectations and engaging in healthy movement behaviours with them. Other sources of influence are important (e.g., child care, school, health care, community, governments) and can support families in this pursuit. Conclusion: Family is important for the support and promotion of healthy movement behaviours of children and youth. This Consensus Statement serves as a comprehensive, credible, and current synopsis of related evidence, recommendations, and resources for multiple stakeholders.
Examining Perceptual Differences Amongst Elite, Intermediate, and Novice Ice Hockey Referees: Visual Attention and Eye Movement Recordings
Creators: name: Hancock, David J
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: sport officials
visual behaviors
decision-making
eye registration

description: Perceptual-cognitive skills are important characteristics for sport participants, which have been shown to contribute to the expert advantage (Abernethy, Baker & Côté, 2005; Mann, Williams, Ward, & Janelle, 2004; McPherson, 2000). One such skill is visual attention, which is beneficial for athletes, but less commonly researched for sport officials. For this dissertation, three data collection procedures assisted in examining the visual behaviors of elite, intermediate and novice ice hockey referees. In phase one, 2 elite, 2 intermediate, and 2 novice referees wore helmet cameras for one game and subsequently participated in stimulated recall interviews to address visual behaviors that occurred during that game. The four resultant themes that emerged were: Divided Attention, Selective Attention, Positioning and Context, and Influences of Visual Attention. Within each of these major themes there were several similarities and differences amongst the referees. In phase two, 2 elite, 2 intermediate, and 2 novice focus groups watched one elite and one intermediate helmet camera videotape and discussed what they thought the referee was attending to and where they would direct their visual attention. The focus group transcripts were deductively coded to search for potential differences between the elite and intermediate referees based on the themes identified in phase one. It was evident that the elite referee was superior to the intermediate in several areas including: Maintaining a focus on the majority of players, knowing when to focus away from the puck, having better post-whistle attention, and being better positioned. Discussion related to how these advantages might be gained by learning through experience. For phase three, 10 elite, 10 intermediate, and 10 novice referees wore an eye-tracking device and made penalty decisions on ice hockey infractions presented on a computer screen. In this experiment, decision accuracy, decision type, number of fixations, and fixation duration were calculated. MANOVA results indicated that there were no significant differences across participant groups. The global discussion includes data excluded from the three main papers, alternative methods for further interpretation of the results, integration of the results of the three papers, and proposals for future research.
title: Опыт сопоставления изданий византийских канонических текстов в Центральной и Восточной Европе в XVI—XVII вв.
Creators: name: Белякова, Елена
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2020

description: Книгопечатание внесло существенные изменения в распространение памятников церковного права. В статье дано сопоставление первых печатных изданий византийских канонических памятников, опубликованных в Западной Европе на греческом языке и на Балканах и Восточной Европы на славянском. В Западной Европе их издавали ученые — преподаватели греческого в университетах и богословы как протестантские, так и католические для подтверждения собственных доктрин и в научных целях изучения греческой культуры. На Балканах и в Восточной Европе первые издания византийских канонических памятников на славянском языке представляли собой сокращенные номоканоны и имели исключительно практический характер и были адресованы священникам. Первым таким изданием был Псевдозонар, изданный как приложение к Молитвеннику в Горажде в 1531 г. В статье приведены примеры использования славянскими книжниками западноевропейских изданий канонических памятников, а также переводы их на славянский язык. Особенное значение имели издания Левенклавия и Бевериджа. Издание Кормчей в Москве стала Corpus iuris Canonici для славянского мира, но новые переводы не были опубликованы. Сопоставление изданий позволяет понять особенности процессов конфессионализации и место книгопечатания в преодолении конфессиональных границ. Изучение состава славянских печатных изданий позволяет лучше понять особенности письменной традиции канонических памятников.
Supplementary document for Robust functional imaging of taste sensation with Bessel beam - 5358507.pdf
Creators: name: Han, Jisoo
name: Kim, Seonghoon
name: Choi, Pyonggang
name: Lee, Sungho
name: Jo, Yongjae
name: KIM, Eunsoo
name: Choi, Myunghwan
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Uncategorized

description: Supplementary Fig. 1
Two-channel data logger for quantitative EEG recording while driving
Creators: name: Gorman, Michael
name: Schier, Mark
Publisher: name: Swinburne
Year: 2024

description: A hardware and software design and development is described for a two-channel portable recording device specifically to collect the electroencephalogram (EEG). The application intended for this device was collection of EEG data from drivers, while driving under controlled conditions on closed roads or circuits. The monitoring of driver reactions may lead to a better understanding of driving abilities and improve road safety. To this end, the design criteria of the portable device included size, weight, power consumption, operating ease, noise immunity, and reliability under extreme conditions. The construction and initial testing has been completed, and the device is now ready for full-scale field experiments.
Organizational Structures, Gender Roles and Upgrading Strategies for Smallholders in Developing Countries’ Local Value Chains
Creators: name: Adetoyinbo, Ayobami
name: Otter, Verena
name: Adetoyinbo, Ayobami
name: Otter, Verena
Publisher: name: Unknown
Year: 2020
Subjects: subject: Agribusiness
subject: Community/Rural/Urban Development
subject: Governance themes
subject: Gender
subject: Global value chain framework
subject: Value web approach
subject: Smallholder upgrading strategies
subject: Nigerian shrimp and prawn

description: To achieve the Sustainable Development Goals, research concepts and empirical evidence are needed to upgrade developing countries’ smallholder activities within local value chains (LVCs). The study aims to uncover LVCs’ (1) organization, (2) governance themes and gender roles for value addition and (3) smallholder upgrading strategies in developing countries’ dualistic sectors. The global value chain (GVC) framework is extended towards a gendered value web approach that captures the importance of hidden gender roles and power relations. Empirical data obtained from 3 focus group discussions and 21 interviews in the Nigerian shrimp and prawn sector represent the basis for qualitative analysis. The results indicate that, despite being driven by competitive traders, mutually reliant coordination between production and processing segments and strategic business activities of female processors are crucial for the LVCs’ functioning. Based on these results, manifold managerial and policy implications which can also apply to other developing countries and cases are derived to upgrade and develop smallholder activities and products along the Nigerian shrimp and prawn LVC.
Supplementary document for Wearable Light Spectral Sensor Optimized for Measuring Daily α-Opic Light Exposure - 5359705.pdf
Creators: name: Kalavally, Vineetha
name: MOHAMED, ANAS
name: Tan, Chee Pin
name: Cain, Sean
name: Phillips, Andrew
name: McGlashan, Elise
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement 1.
Supplementary document for Wearable Light Spectral Sensor Optimized for Measuring Daily α-Opic Light Exposure - 5359705.pdf
Creators: name: Kalavally, Vineetha
name: MOHAMED, ANAS
name: Tan, Chee Pin
name: Cain, Sean
name: Phillips, Andrew
name: McGlashan, Elise
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Uncategorized

description: Supplement 1.
Resource-based view of the firm and competitive advantage
Creators: name: Clulow, Val
name: Gerstman, Julie
name: Barry, Carol
Publisher: name: Swinburne
Year: 2024

description: The resource-based view (RBV) of the firm offers a further perspective to marketing strategists that concentrates on key resources of the firm and how they might influence sustainable competitive advantage (SCA), rather than the industry perspective more often applied by marketers. In this paper it is argued that the model developed by Fahy (2000) offers a concise picture of the elements that impact on the firm which can be further developed to explain competitive advantage. A research approach using an interview schedule is proposed as an appropriate methodology by which to explore the key intangible assets and capabilities (key resources) and the process by which high performing firms identify, develop, deploy and protect their key resources in sustaining competitive advantage. The outcomes of studies based on this research question have implications not only for the debate over the role of industry structure versus key resources in explaining a SCA, but for marketing strategists who seek every opportunity to manipulate and manage the variables that influence competitive advantage.
Alterations of the Monoaminergic Systems in the Rat Brain by Sustained Administration of Carisbamate and Lamotrigine
Creators: name: Shim, Stacey
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: anticonvulsants
in vivo electrophysiology
major depressive disorder

description: Carisbamate (CRS) and lamotrigine (LTG) are anticonvulsants which act mainly on neuronal voltage-gated sodium channels, that have been shown to have antidepressant-like effects in animal models of depression. In vivo electrophysiological recordings were carried out following 2 and 14 days of CRS or LTG administration. Overall firing activity in the dorsal raphe, locus coeruleus and ventral tegmental area were decreased with CRS. Similarly, a decrease in the dorsal raphe was also observed with LTG. Despite these presynaptic decreases in firing activity, both anticonvulsants exhibited significant enhancement of serotonergic transmission in the hippocampus as demonstrated by increased tonic activation of postsynaptic 5-HT1A receptors. This may be attributed to the observed desensitization of the terminal 5-HT1B autoreceptors. This study suggests that the enhanced serotonergic effect may be associated with an antiglutamatergic effect, and may contribute to the antidepressant-like effect of CRS in the forced swim test and the antidepressant properties of LTG.
Methionine metabolism in epigenetics of pluripotency and the germ line
Creators: name: Akademir, Eren
Publisher: name: Imperial College London
Year: 2022

description: Metabolism sustains living organisms by generating the necessary molecular building blocks from nutrients in the environment. Intermediates in metabolic reaction pathways serve as critical substrates and cofactors to modify chromatin, making cellular metabolism a fundamental aspect of genome regulation and cell identity. S-adenosylmethionine (SAM) is an important co-factor for RNA, DNA and histone methylation. SAM is linked to the immediate precursor methionine (Met) and the one-carbon (1C) metabolic network more broadly, whose flux can influence abundance of SAM availability and therefore overall activity of epigenetic enzymes. My thesis examines the influence of 1C and Met metabolism on the epigenetic and epitranscriptomic regulation of pluripotent mouse embryonic stem cells (mESCs) cultured in two interchangeable conditions, 2i and Serum/Lif (SL). Using Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) and stable isotope labelling (SIL) approaches, I determined hitherto unreported metabolic features that underlie the distinct epigenetic profiles of mESCs in these two conditions, including regulation of sulphur metabolism and methyl flux from Met and SAM. Notably, by using dialysed serum to control for serum’s amino-acid rich content, I significantly revise the consensus that mESCs are especially dependent on Thr, demonstrating that mESCs are also highly dependent on Met to proliferate normally and maintain their epigenetic configuration. Culture environment containing low Met concentrations for mESCs elicited a global histone response characterised by generally reduced methylation and increased acetylation. In SL-cultured mESCs, Met depletion caused reduced protein levels of OCT4 and NANOG pluripotency factors, along with diminished DNA and N6-methyladenosine (m6A) RNA methylation, encouraging significant questions into the interplay of Met and epigenetic marks in regulating the wider pluripotency network. My results significantly add to current knowledge of mESC metabolism and epigenetics, and may also have implications for our understanding of developmental epigenetic processes. Specifically, this work will help inform our efforts to delineate the role of metabolism in germline epigenetic reprogramming of primordial germ cells, in which genome-wide DNA demethylation and chromatin remodelling is accompanied by dynamic expression of 1C-metabolic enzymes.
Engineering the microbiome under individualized perturbations
Creators: name: García-Jiménez, Beatriz
name: Medina, Joaquín
name: Wilkinson, Mark D.
Publisher: name: F1000 Research Limited
Year: 2020

description: Abstract:
Microbiome dynamics studies highlight the inability to predict the effects of external perturbation on complex microbial communities over time.
MDPbiome contributes to addressing this challenge, in the context of moving microbiome studies from descriptive to translational approaches. MDPbiome is an Artificial Intelligence system built using Markov Decision Processes (MDP) to provide in-silico recommendations (e.g., about diet, pre/pro-biotics, drugs, etc.) to guide the subject’s microbiome through a path towards health or high performance, relying on microbial community changes in response to perturbations.

In addition, given the lack of experimental longitudinal microbiome datasets, we have designed a novel system to simulate the dynamics of microbial communities under perturbations using genome-scale metabolic models (GEMs), called MMODES. This makes possible to extend the application of MDPbiome to novel microbial synthetic communities and suggest interventions to modulate them to preserve or to reach a desired state. Interventions can be modifications to the nutrients in the medium or the microorganisms in the community.

MDPbiome and MDPbiomeGEM (MDPbiome plus MMODES) systems have been successfully applied to several real and simulated case studies in human, animal and soil microbiomes, to chick gut flora maturation, soil decontamination, to recover from Crohn's disease, and to avoid bacterial vaginosis.

Funding
Research was supported by the “Severo Ochoa Program for Centres of Excellence in R&D” from the Agencia Estatal de Investigación of Spain (grant SEV-2016-0672 (2017-2021)) to the CBGP. BGJ was supported by a Postdoctoral contract associated to the Severo Ochoa Program.
A temporal study of PFCAs and their precursors in human plasma from two German cities 1982-2009
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2013

description: A total of 420 human plasma samples from two cities (Halle and Münster, Germany), collected between 1982 and 2009, were analyzed for a suite of PFCAs (C6-C12) and selected PFCA precursors (4:2-, 4:2/6:2-, 6:2-, 6:2/8:2-, 8:2-, 8:2/10:2- and 10:2 diPAPs). PFCAs (C7 - C11, 13) were detected in over 80% of the samples (<0.005 - 39.4 ng/mL) while C12 PFCA was detected in fewer than 10% of the samples. In a range of 10-46% of the samples, 4:2-, 4:2/6:2-, 6:2, and 8:2- diPAPs were identified at concentrations of <0.0002 ng/mL to 0.687 ng/mL; fewer than 10% of the samples had detectable 10:2 diPAP. Temporal trends (2000-2009) showed increasing concentrations of PFNA, PFDA, and PFUnDA, whereas PFOA concentrations were decreasing. Calculated population halving time for PFOA varied between 8.2 - 14.5 years which contrasts to the generally accepted value of 3.8 years. This suggests an ongoing or additional exposure to PFOA or one of its precursor compounds. DiPAPs, known to metabolize rapidly to PFCAs, were detected in a significant number of samples and at concentrations that have not declined significantly over the past half-decade. The evidence suggests they have contributed to the continued presence of the longer chain PFCAs and perhaps contribute to the slow decline of PFOA.
Quelle: http://www.umweltprobenbank.de/
Engineering the microbiome under individualized perturbations
Creators: name: García-Jiménez, Beatriz
name: Medin, Joaquín
name: Wilkinson, Mark D.
Publisher: name: F1000 Research Limited
Year: 2020

description: Abstract:
Microbiome dynamics studies highlight the inability to predict the effects of external perturbation on complex microbial communities over time.
MDPbiome contributes to addressing this challenge, in the context of moving microbiome studies from descriptive to translational approaches. MDPbiome is an Artificial Intelligence system built using Markov Decision Processes (MDP) to provide in-silico recommendations (e.g., about diet, pre/pro-biotics, drugs, etc.) to guide the subject’s microbiome through a path towards health or high performance, relying on microbial community changes in response to perturbations.

In addition, given the lack of experimental longitudinal microbiome datasets, we have designed a novel system to simulate the dynamics of microbial communities under perturbations using genome-scale metabolic models (GEMs), called MMODES. This makes possible to extend the application of MDPbiome to novel microbial synthetic communities and suggest interventions to modulate them to preserve or to reach a desired state. Interventions can be modifications to the nutrients in the medium or the microorganisms in the community.

MDPbiome and MDPbiomeGEM (MDPbiome plus MMODES) systems have been successfully applied to several real and simulated case studies in human, animal and soil microbiomes, to chick gut flora maturation, soil decontamination, to recover from Crohn's disease, and to avoid bacterial vaginosis.

Funding:
Research was supported by the “Severo Ochoa Program for Centres of Excellence in R&D” from the Agencia Estatal de Investigación of Spain (grant SEV-2016-0672 (2017-2021)) to the CBGP. BGJ was supported by a Postdoctoral contract associated to the Severo Ochoa Program.
title: Эмиль Легран и русская византинистика: новые архивные данные
Creators: name: Герд, Лора
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2020

description: Французский византинист, лингвист и библиограф Эмиль Легран при составлении «Греческой библиографии» имел обширную переписку со многими учеными современниками. Среди его русских корреспондентов были И.В.Помяловский, библиотекарь русского монастыря на Афоне о. Матфей (Ольшанский) и А.И.Кирпичников. Публикация посвящена письмам этих ученых из парижского архива Леграна, хранящегося в Институте новогреческих исследований. Содержанием писем стали библиографические разыскания в библиотеках Петербурга и монастыря Св. Пантелеимона, а также подготовка издания писем Димитрия Кидониса к Мануилу Палеологу.
Physical properties of the sea drag
Creators: name: Babanin, Alexander
name: Makin, V. K.
Publisher: name: Swinburne
Year: 2024

description: The air-sea coupling is usually parameterized in terms of the drag coefficient Cd, but the scatter of experimental data around such dependences is very significant and has not improved noticeably over some 30 years. In the paper, a complex approach to the problem is suggested. Multiple mechanisms, contributing into the sea drag, are to be singled out, studied separately, evaluated and then reunited in a joint parameterization for Cd. The approach also combines an experimental Lake George study with theoretical investigations conducted by means of the WOWC (Wind-Over-Waves Coupling) model. Overall agreement of the model with measured wind stresses is quite good, within 20% for the bulk of the data. Dependences of the drag coefficient on the wind speed and sea state, and effects of wind trends and gustiness are investigated in detail. Gustiness is found to be responsible for the most distant outliers. Lower envelopes of the drag dependences are an important result of the paper. They provide some Lake George 'ideal' relationships for the sea drag. Almost any deviation from such conditions causes the drag to increase. It is suggested that decrease of the drag with respect to the ideal conditions, which exhibits itself in a number of known open ocean data sets, would be caused by a momentum flux back from the waves to the wind due to long waves outrunning the wind. Behaviour of the Charnock parameter in terms of wave age is also considered.
Império das imagens e fluidez das identificações (Empire of images and fluidity of identifications)
Creators: name: Castro, Julio Cesar Lemes De
Publisher: name: figshare
Year: 2020
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 220317 Poststructuralism
subject: FOS: Philosophy, ethics and religion
subject: 220318 Psychoanalytic Philosophy

description: The regime of power characteristic of modernity is exercised, according to Foucault's analysis, within the different disciplinary institutions - the factory, the school, the barracks, the hospital, the prison. We can say that each of these institutions value a certain kind of ego ideal, coupled with a repressive superego which monitors the adherence to normative standards. With the decline of the repressive superego accompanying the rise of imaginary, the disciplinary society examined by Foucault gives way to the society of control envisioned by Deleuze. To the extent that this ego ideal is coupled to a superego ordering enjoyment, while the normalizing effect of the repressive superego is eclipsed, it is possible the multiplication of symbolic models of identification. The bigger latitude of the ego ideal entails the plasticity of the ideal ego, which no longer fits predetermined molds, but can modulate itself in accordance with the circumstances. / O regime de poder característico da modernidade é exercido, conforme a análise de Foucault, no interior das diferentes instituições disciplinares – a fábrica, a escola, o quartel, o hospital, a prisão. Podemos dizer que cada uma dessas instituições valoriza um certo tipo de ideal do eu, acoplado a um supereu repressivo que zela pela adesão aos padrões normativos. Com o declínio do supereu repressivo que acompanha a escalada do imaginário, a sociedade disciplinar examinada por Foucault dá lugar à sociedade de controle vislumbrada por Deleuze. Na medida em que nesta o ideal do eu está acoplado a um supereu que ordena o gozo, enquanto o efeito normatizador do supereu repressivo se eclipsa, nela se torna possível a multiplicação dos modelos simbólicos de identificação. À maior latitude do ideal do eu corresponde a plasticidade do eu ideal, que não precisa mais se adequar a moldes preestabelecidos, mas pode modular-se de acordo com as circunstâncias.
Supplementary document for Coherent generation of arbitrary first-order Poincaré sphere beams on a Si chip - 5360787.pdf
Creators: name: Pi, Hailong
name: Yu, Wangke
name: Yan, Jize
name: Fang, Xu
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary figure on field distribution around a nanohole
Implementation opportunities and challenges identified by key stakeholders in scaling up HIV Treatment as Prevention in British Columbia, Canada: a qualitative study
Creators: name: Chayama, Koharu L.
name: McNeil, Ryan, 1982-
name: Shoveller, Jean
name: Small, Will
name: Knight, Rod E.
Publisher: name: BioMed Central
Year: 2020

description: Background: The province of British Columbia (BC), Canada, was among the first jurisdictions to scale up HIV Treatment as Prevention (TasP) to the population level, including funding and policy commitments that enhanced HIV testing efforts (e.g., expansion of routine, opt-out testing), while also making antiretroviral therapy universally available to all people living with HIV. As such, BC represents a critical context within which to identify factors that influenced the scalability of TasP (e.g., acceptability, adoption, fidelity, equitable reach, sustainability), including key opportunities and challenges. Methods: We draw on in-depth, semi-structured interviews with 10 key stakeholders, comprised policymakers at the local and provincial levels and representatives from community-based organizations. Using the Consolidated Framework for Implementation Research (CFIR) to guide data collection, coding, and analysis, we identified key factors that influenced practice transformation and scale up. Results: Key factors that contributed to the successful scale up of TasP included: (i) opportunities that enhanced stakeholder buy-in based on features of the intervention characteristics, including with regard to assessments about the quality and strength of evidence supporting TasP; (ii) an inner setting implementation climate that was, in part, shaped by the large and highly symbolic government investments into TasP; (iii) features of the outer setting such as external policies (e.g., harm reduction) that cultivated opportunities to implement new “systems-level” approaches to HIV intervention; (iv) the personal attributes of some “middle-level” influencers, including a team that was comprised of some highly motivated and social justice-oriented individuals (e.g., folks who were deeply committed to serving marginalized populations); and (v) the capacity to develop various implementation processes that could maintain “nimble and evidence-informed” adaptations across a highly decentralized service delivery system, while also creating opportunities to adapt features of TasP programming based on “real time” program data. Conclusion: Constructs across all five domains of CFIR (intervention characteristics, outer setting, inner setting, characteristics of individuals, and process) were identified to influence the success of TasP in BC. Our findings provide important insights into how BC can successfully implement and scale up other systems-level interventions that have demonstrated efficacy, while also offering insights for other jurisdictions that are currently or planning to scale up TasP.