cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Regulation of the MDM2-p53 Pathway by Ribosomal Protein L11 Involves a Post-ubiquitination Mechanism
Creators: name: Lu, Hua
name: Zhang, Yanping
name: Sun, Xiao Xin
name: Jin, Yetao
name: Grossman, Steven R.
name: Shi, Dingding
name: Dai, Mu Shui
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Inhibition of the MDM2-p53 feedback loop is critical for p53 activation in response to cellular stresses. The ribosomal proteins L5, L11, and L23 can block this loop by inhibiting MDM2-mediated p53 ubiquitination and degradation in response to ribosomal stress. Here, we show that L11, but not L5 and L23, leads to a drastic accumulation of ubiquitinated and native MDM2. This effect is dependent on the ubiquitin ligase activity of MDM2, but not p53, and requires the central MDM2 binding domain (residues 51–108) of L11. We further show that L11 inhibited 26 S proteasome-mediated degradation of ubiquitinated MDM2 in vitro and consistently prolonged the half-life of MDM2 in cells. These results suggest that L11, unlike L5 and L23, differentially regulates the levels of ubiquitinated p53 and MDM2 and inhibits the turnover and activity of MDM2 through a post-ubiquitination mechanism.
Organisation et fonctionnement trophiques de l'assemblage ichtyque d'un écosystème lagunaire à mangrove antillais aumoyen de l'indice trophique de contribution
Creators: name: CABERTY, Sylvain
name: BOUCHEREAU, Jean-Luc
name: CHAVES, Paulo De Tarso
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2004

description: Trophic organisation and functioning of ichthyic populations in a West Indies mangrove ecosystem using the tro-
 phic contribution index. The ichthyofauna of the Manche-à-Eau lagoon was regularly sampled in 2002 with a fixed net in
 seven stations, under various hydrological influences. The results obtained and the data drawn from the literature on the
 trophic and occupancy guilds are used to characterize the trophic organization and functioning of the ichthyofauna. The tro-
 phic contribution index of Chaves & Bouchereau (2004), measuring the respective influences of the input in detritus and
 primary production energy resources exploited by a fish assemblage, is evaluated in the lagoon and compared with that
 already obtained in another mangrove estuary, the Bay of Guaratuba. All the trophic and occupancy guilds are represented
 in the lagoon. In this assemblage of 39 species and 25 families, the fishes feed preferentially on invertebrates associated or
 not with plants or fish, like that of Guaratuba The small number of piscivorous species is a common trait to many mangro-
 ve ecosystems. The occupancy guilds are represented differently in biomass: in the lagoon, migrant and occasional species
 dominate in different proportions; in Guaratuba, resident and migrant dominate in equivalent proportions. The residents of
 the two ecosystems exploit similarly the available resources, showing their strong adaptiveness. Residents, primarily detri-
 tivorous, and migrants, exploit alternatively detritus and primary production without trophic competition. The trophic
 guilds of migrants are equitably represented.
New HSL Distance Based Colour Clustering Algorithm
Creators: name: Patrascu, Vasile
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: In this paper, we define a distance for the HSL colour system. Next, the proposed distance is used for a fuzzy colour clustering algorithm construction. The presented algorithm is related to the well-known fuzzy c-means algorithm. Finally, the clustering algorithm is used as colour reduction method. The obtained experimental results are presented to demonstrate the effectiveness of our approach.
description: The 24th Midwest Artificial Intelligence and Cognitive Sciences Conference (MAICS 2013), pp. 85-92, New Albany, Indiana. USA, April 13-14, 2013
Comparison of the fish assemblages in tidal salt marsh creeks and in adjoining mudflat areas in the Tejo estuary (Portugal)
Creators: name: SALGADO, João
name: COSTA, Maria José
name: CABRAL, Henrique
name: DEEGAN, Linda
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2004

description: A comparative analysis of the fish assemblages in two tidal salt marsh creeks and in the adjoining mudflat areas
 was conducted, based on two years of sampling surveys performed in different years, using a fyke net and a beam trawl,
 respectively. Fish species richness was higher in the mudflat areas (27 species) than in the tidal creeks (14 species). Liza
 ramada and Pomatoschistus microps were the most abundant species in tidal creeks, while the adjoining tidal flats were
 dominated by P. microps and Pomatoschistus minutus. The seasonal pattern of variation was different in the two habitat
 types. The main differences observed were mainly related with peak abundance of resident species and periods of estuari-
 ne colonization by juveniles of marine species that used the estuary as nursery area. The results obtained emphasize the
 importance of intertidal creek habitat within the estuarine environment for some fish species, particularly as juveniles. The
 utilization of this habitat is mainly related with feeding and predation avoidance.
(4062) John Fraser
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 1 of Effectiveness of work-related interventions for return to work in people on sick leave: a systematic review and meta-analysis of randomized controlled trials
Creators: name: Tingulstad, Alexander
name: Meneses-Echavez, Jose
name: Evensen, Line Holtet
name: Bjerk, Maria
name: Berg, Rigmor C.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Appendix 1. Protocol. Appendix 2. Search strategy. Appendix 3. Excluded studies and reason. Appendix 4. Certainty of evidence for secondary outcomes.
(4063) Lilly Fraser [same maiden name]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Apolipoprotein E4 in Macrophages Enhances Atherogenesis in a Low Density Lipoprotein Receptor-dependent Manner
Creators: name: Johnson, Lance
name: Wilder, Jennifer
name: Maeda, Nobuyo
name: Altenburg, Michael
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Apolipoprotein E (apoE) and the low density lipoprotein receptor (LDLr) are well recognized determinants of atherosclerosis. In addition to hepatocytes, where both are highly expressed and contribute to plasma lipoprotein clearance, they are expressed in vascular cells and macrophages. In this study, we examined the effects of human apoE isoforms and LDLr levels in atherogenic pathways in primary macrophages ex vivo and atherosclerosis development after bone marrow transfer in vivo using mice expressing human apoE isoforms and different levels of LDLr expression. Increases in LDLr expression significantly increased cholesterol delivery into macrophages in culture, and the effects were more prominent with lipoproteins containing apoE4 than those containing apoE3. Conversely, increased LDLr expression reduced cholesterol efflux in macrophages expressing apoE4 but not in macrophages expressing apoE3. Furthermore, apoE3 protected VLDL from oxidation in vitro more than did apoE4. In LDLr-deficient mice expressing the human apoE4 isoform, Apoe4/4 Ldlr−/−, the replacement of bone marrow cells with those expressing LDLr increased atherosclerotic lesions in a dose-dependent manner compared with mice transplanted with cells having no LDLr. In contrast, atherosclerosis in Apoe3/3 Ldlr−/− mice, expressing the human apoE3 isoform, did not differ by the levels of macrophage LDLr expression. Our results demonstrate that apoE4, but not apoE3, in macrophages enhances atherosclerotic plaque development in mice in an LDLr-dependent manner and suggests that this interaction may contribute to the association of apoE4 with an increased cardiovascular risk in humans.
Range-separated time-dependent density-functional theory with a frequency-dependent second-order Bethe-Salpeter correlation kernel
Creators: name: Rebolini, Elisa
name: Toulouse, Julien
Publisher: name: arXiv
Year: 2015
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: We present a range-separated linear-response time-dependent density-functional theory (TDDFT) which combines a density-functional approximation for the short-range response kernel and a frequency-dependent second-order Bethe-Salpeter approximation for the long-range response kernel. This approach goes beyond the adiabatic approximation usually used in linear-response TDDFT and aims at improving the accuracy of calculations of electronic excitation energies of molecular systems. A detailed derivation of the frequency-dependent second-order Bethe-Salpeter correlation kernel is given using many-body Green-function theory. Preliminary tests of this range-separated TDDFT method are presented for the calculation of excitation energies of the He and Be atoms and small molecules (H2, N2, CO2, H2CO, and C2H4). The results suggest that the addition of the long-range second-order Bethe-Salpeter correlation kernel overall slightly improves the excitation energies.
description: in The Journal of Chemical Physics, American Institute of Physics, 2016
Mitigating Cosmic Microwave Background Shadow Degradation of Tensor-to-scalar Ratio Measurements through Map-based Studies
Creators: name: Murokoshi, Tamaki
name: Chinone, Yuji
name: Nashimoto, Masashi
name: Ichiki, Kiyotomo
name: Hattori, Makoto
Publisher: name: arXiv
Year: 2023
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: It has been pointed out that the spurious Cosmic Microwave Background (CMB) B-mode polarization signals caused by the absorption of the CMB monopole component due to the Galactic interstellar matter, called the CMB shadow, degrade the accuracy of detecting the CMB B-mode polarization signals imprinted by primordial gravitational waves. We have made a realistic estimation using simulated sky maps of how the CMB shadow affects forthcoming high-precision CMB B-mode experiments for the first time. The Delta-map method, an internal template method taking into account the first-order spatial variation of foregrounds' spectral parameters, is applied as a foreground removal method. We show that if the CMB shadow effects are not taken into account in the foreground removal process, future observations would lead to the false detection of the CMB B-mode polarization signals originating from primordial gravitational waves. We also show that the effect of the CMB shadow can be mitigated by our revised Delta-map method to target the CMB B-mode polarization signals at the level of tensor-to-scalar ratio r=0.001.
description: 9 pages, 2 figures
High-Order Kinetic Relaxation Schemes as High-Accuracy Poisson Solvers
Creators: name: Mendoza, M.
name: Succi, S.
name: Herrmann, H. J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computational Physics (physics.comp-ph)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: We present a new approach to find accurate solutions to the Poisson equation, as obtained from the steady-state limit of a diffusion equation with strong source terms. For this purpose, we start from Boltzmann's kinetic theory and investigate the influence of higher order terms on the resulting macroscopic equations. By performing an appropriate expansion of the equilibrium distribution, we provide a method to remove the unnecessary terms up to a desired order and show that it is possible to find, with high level of accuracy, the steady-state solution of the diffusion equation for sizeable Knudsen numbers. In order to test our kinetic approach, we discretise the Boltzmann equation and solve the Poisson equation, spending up to six order of magnitude less computational time for a given precision than standard lattice Boltzmann methods.
description: 16 pages, 6 figures
EFFECTS OF MACROFAUNA EXCRETION AND TURBULENCE ON INORGANIC NITROGENOUS EXCHANGES AT THE WATER-SEDIMENT INTERFACE - EXPERIMENTAL APPROACH IN MICROCOSMS
Creators: name: Regnault, M.
name: Boucherrodoni, R.
name: Boucher, G.
name: Lasserre, P.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1988

Abstract
Binary Properties from Cepheid Radial Velocities (CRaV)
Creators: name: Evans, Nancy Remage
name: Berdnikov, Leonid
name: Lauer, Jennifer
name: Morgan, Douglas
name: Nichols, Joy
name: Günther, H. Moritz
name: Gorynya, Natalya
name: Rastorguev, Alexey
name: Moskalik, Pawel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We have examined high accuracy radial velocities of Cepheids to determine the binary frequency. The data are largely from the CORAVEL spectrophotometer and the Moscow version, with a typical uncertainty of $\leq1$~km~s$^{-1}$, and a time span from 1 to 20 years. A systemic velocity was obtained by removing the pulsation component using a high order Fourier series. From this data we have developed a list of stars showing no orbital velocity larger than $\pm1$~km~s$^{-1}$. The binary fraction was analyzed as a function of magnitude, and yields an apparent decrease in this fraction for fainter stars. We interpret this as incompleteness at fainter magnitudes, and derive the preferred binary fraction of $29\pm8$\% ( $20\pm6$\% per decade of orbital period) from the brightest 40 stars. Comparison of this fraction in this period range (1-20 years) implies a large fraction for the full period range. This is reasonable in that the high accuracy velocities are sensitive to the longer periods and smaller orbital velocity amplitudes in the period range sampled here. Thus the Cepheid velocity sample provides a sensitive detection in the period range between short period spectroscopic binaries and resolved companions. The recent identification of $δ$ Cep as a binary with very low amplitude and high eccentricity underscores the fact that the binary fractions we derive are lower limits, to which other low amplitude systems will probably be added. The mass ratio (q) distribution derived from ultraviolet observations of the secondary is consistent with a flat distribution for the applicable period range (1 to 20 years).
description: accepted for publication in AJ
Exact upper and lower bounds on the difference between the arithmetic and geometric means
Creators: name: Pinelis, Iosif
Publisher: name: arXiv
Year: 2015
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: primary 60E15, secondary 26D15, 90C46

description: Let $X$ denote a nonnegative random variable with $\mathsf{E} X
description: 8 pages; to appear in the Bulletin of the Australian Mathematical Society. Version 2: the condition that the random variable X is nonnegative was missing in the abstract
Cdc7-Dbf4 and the Human S Checkpoint Response to UVC
Creators: name: Simpson, Dennis A.
name: Heffernan, Timothy P.
name: Ünsal-Kaçmaz, Keziban
name: Kaufmann, William K.
name: Heinloth, Alexandra N.
name: Cordeiro-Stone, Marila
name: Paules, Richard S.
name: Sancar, Aziz
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: The S checkpoint response to ultraviolet radiation (UVC) that inhibits replicon initiation is dependent on the ATR and Chk1 kinases. Downstream effectors of this response, however, are not well characterized. Data reported here eliminated Cdc25A degradation as intrinsic components of the UVC-induced pathway of inhibition of replicon initiation in human cells. A sublethal dose of UVC (1 J/m2), which selectively inhibits replicon initiation by 50%, failed to reduce the amount of Cdc25A protein or decrease Cdk2/cyclin E kinase activity. Cdc25A degradation was observed after irradiation with cytotoxic fluences of UVC, suggesting that severe inhibition of DNA chain elongation and activation of the replication checkpoint might be responsible for the UVC-induced degradation of Cdc25A. Another proposed effector of the S checkpoint is the Cdc7/Dbf4 complex. Dbf4 interacted with Chk1 in vivo and was recognized as a substrate for Chk1-dependent phosphorylation in vitro. Flag-Dbf4 formed complexes with endogenous Cdc7 and this interaction was stable in UVC-irradiated HeLa cells. Over-expression of Flag- or Myc-tagged Dbf4 abrogated the S checkpoint response to UVC. These findings implicate a Dbf4-dependent kinase as a possible target of the ATR- and Chk1-dependent S checkpoint response to UVC.
(4059) Andrew Crawford
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
"I'm fully who I am": Towards Centering Transgender and Non-Binary Voices to Measure Biases in Open Language Generation
Creators: name: Ovalle, Anaelia
name: Goyal, Palash
name: Dhamala, Jwala
name: Jaggers, Zachary
name: Chang, Kai-Wei
name: Galstyan, Aram
name: Zemel, Richard
name: Gupta, Rahul
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computation and Language (cs.CL)
subject: Artificial Intelligence (cs.AI)
subject: Computers and Society (cs.CY)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences
subject: I.2; I.7; K.4

description: Transgender and non-binary (TGNB) individuals disproportionately experience discrimination and exclusion from daily life. Given the recent popularity and adoption of language generation technologies, the potential to further marginalize this population only grows. Although a multitude of NLP fairness literature focuses on illuminating and addressing gender biases, assessing gender harms for TGNB identities requires understanding how such identities uniquely interact with societal gender norms and how they differ from gender binary-centric perspectives. Such measurement frameworks inherently require centering TGNB voices to help guide the alignment between gender-inclusive NLP and whom they are intended to serve. Towards this goal, we ground our work in the TGNB community and existing interdisciplinary literature to assess how the social reality surrounding experienced marginalization of TGNB persons contributes to and persists within Open Language Generation (OLG). This social knowledge serves as a guide for evaluating popular large language models (LLMs) on two key aspects: (1) misgendering and (2) harmful responses to gender disclosure. To do this, we introduce TANGO, a dataset of template-based real-world text curated from a TGNB-oriented community. We discover a dominance of binary gender norms reflected by the models; LLMs least misgendered subjects in generated text when triggered by prompts whose subjects used binary pronouns. Meanwhile, misgendering was most prevalent when triggering generation with singular they and neopronouns. When prompted with gender disclosures, TGNB disclosure generated the most stigmatizing language and scored most toxic, on average. Our findings warrant further research on how TGNB harms manifest in LLMs and serve as a broader case study toward concretely grounding the design of gender-inclusive AI in community voices and interdisciplinary literature.
Domain Swapping within PDZ2 Is Responsible for Dimerization of ZO Proteins
Creators: name: Anderson, James M.
name: Fanning, Alan S.
name: Lavie, Arnon
name: Lye, Ming F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: ZO-1 is a multidomain protein involved in cell-cell junctions and contains three PDZ domains, which are necessary for its function in vivo. PDZ domains play a central role in assembling diverse protein complexes through their ability to recognize short peptide motifs on other proteins. We determined the structure of the second of the three PDZ domains of ZO-1, which is known to promote dimerization as well as bind to C-terminal sequences on connexins. The dimer is stabilized by extensive symmetrical domain swapping of β-strands, which is unlike any other known mechanism of PDZ dimerization. The canonical peptide-binding groove remains intact in both subunits of the PDZ2 dimer and is created by elements contributed from both monomers. This unique structure reveals an additional example of how PDZ domains dimerize and has multiple implications for both peptide binding and oligomerization in vivo.
(4060) Isabella [Crawford]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Coordinated Regularized Zero-Forcing Precoding for Multicell MISO Systems with Limited Feedback
Creators: name: Mirza, Jawad
name: Smith, Peter J.
name: Dmochowski, Pawel A.
name: Shafi, Mansoor
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: We investigate coordinated regularized zero-forcing precoding for limited feedback multicell multiuser multiple-input single-output systems. We begin by deriving an approximation to the expected signal-to-interference-plus-noise ratio for the proposed scheme with perfect channel direction information (CDI) at the base station (BS). We also derive an expected SINR approximation for limited feedback systems with random vector quantization (RVQ) based codebook CDI at the BS. Using the expected interference result for the RVQ based limited feedback CDI, we propose an adaptive feedback bit allocation strategy to minimize the expected interference by partitioning the total number of bits between the serving and out-of-cell interfering channels. Numerical results show that the proposed adaptive feedback bit allocation method offers a spectral efficiency gain over the existing coordinated zero-forcing scheme.
description: 9 pages, 7 figures, accepted in IEEE Transactions on Vehicular Technology
Ethanol-induced Modulation of Hepatocellular Extracellular Signal-regulated Kinase-1/2 Activity via 4-Hydroxynonenal
Creators: name: Petersen, Dennis R.
name: Stewart, Benjamin J.
name: Sampey, Brante P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Modulation of the extracellular signal-regulated kinases (ERK-1/2), a signaling pathway directly associated with cell proliferation, survival, and homeostasis, has been implicated in several pathologies, including alcoholic liver disease. However, the underlying mechanism of ethanol-induced ERK-1/2 modulation remains unknown. This investigation explored the effects of ethanol-associated oxidative stress on constitutive hepatic ERK-1/2 activity and assessed the contribution of the lipid peroxidation product 4-hydroxynonenal (4-HNE) to the observations made in vivo. Constitutive ERK-1/2 phosphorylation was suppressed in hepatocytes isolated from rats chronically consuming ethanol for 45 days. This observation was associated with an increase in 4-HNE-ERK monomer adduct concentration and a hepatic cellular and lobular redistribution of ERK-1/2 that correlated with 4-HNE-protein adduct accumulation. Chronic ethanol consumption was also associated with a decrease in hepatocyte nuclear ELK-1 phosphorylation, independent of changes in total nuclear ELK-1 protein. Primary hepatocytes treated with concentrations of 4-HNE consistent with those occurring during oxidative stress displayed a concentration-dependent decrease in constitutive ERK-1/2 phosphorylation, activity, and nuclear localization that negatively correlated with 4-HNE-ERK-1/2 monomer adduct accumulation. These data paralleled the decreased phosphorylation of the downstream kinase ELK-1. Molar ratios of purified ERK-2 to 4-HNE consistent with pathologic ratios found in vivo resulted in protein monomer-adduct formation across a range of concentrations. Collectively, these data demonstrate a novel association between ethanol-induced lipid peroxidation and the inhibition of constitutive ERK-1/2, and suggest an inhibitory mechanism mediated by the lipid peroxidation product 4-hydroxynonenal.
A new and primitive genus and species of deep-sea Tegastidae (Crustacea, Copepoda, Harpacticoida) from the Mid-AtlanticRidge, 37°N (Azores Triple Junction, Lucky Strike)
Creators: name: IVANENKO, Viatcheslav N.
name: DEFAYE, Danielle
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2004

description: Smacigastes micheli gen. nov., sp. nov. (Copepoda, Harpacticoida, Tegastidae) is described, from specimens
 obtained during in situ colonization experiments in the Mid-Atlantic Ridge (37°N, Lucky Strike), at a depth of 1698 m.
 This is the first record of tegastids in the deep-sea. The distinctive and primitive features of the new genus allowing an
 amendment of the family diagnosis are the elongate caudal rami, the 10-segmented male antennule and the leg 6 represen-
 ted by 2 small setae on the ventral side of the female genital double-somite. The fusion of the left genital flap with the male
 genital double-somite and the slight (clockwise from ventral view) torsion of the flaps relative to the dorso-ventral axis of
 the genital double-somite are the presumed derived features of the new genus.
FoxP3 Enhances HIV-1 Gene Expression by Modulating NFκB Occupancy at the Long Terminal Repeat in Human T Cells
Creators: name: Su, Lishan
name: Mackey-Cushman, Stephanie
name: Holmes, Derek
name: Knudsen, Geoffry
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: FoxP3 determines the development of CD4+CD25+ regulatory T (Treg) cells and represses interleukin-2 (IL-2) expression in Treg cells. However, human immunodeficiency virus type 1 (HIV-1) infects and replicates efficiently in FoxP3+ Treg cells. We report that, while inhibiting IL-2 gene expression, FoxP3 enhances gene expression from HIV-1 long terminal repeat (LTR). This FoxP3 activity requires both the N- and C-terminal domains and is inactivated by human IPEX (immunodysregulation, polyendocrinopathy, enteropathy, X-linked syndrome) mutations. FoxP3 enhances HIV-1 LTR via its specific NFκB binding sequences in an NFκB-dependent fashion in T cells but not in HEK293 cells. FoxP3 decreases level of histone acetylation at the interleukin-2 locus but not at the HIV-1 LTR. Although NFκB nuclear translocation is not altered, FoxP3 enhances NFκB-p65 binding to HIV-1 LTR. These data suggest that FoxP3 modulates gene expression in a promoter sequence-dependent fashion by modulating chromatin structure and NFκB activity. HIV-1 LTR has evolved to both highjack the T-cell activation pathway for expression and to resist FoxP3-mediated suppression of T-cell activation.
Effects of ageing on pro-arrhythmic ventricular phenotypes in incrementally paced murine Pgc1β-/- hearts
Creators: name: Ahmad, Shiraz
name: Valli, H
name: Edling, C
name: Grace, Andrew
name: Jeevaratnam, K
name: Huang, Christopher Li-Hur
Publisher: name: Apollo - University of Cambridge Repository
Year: 2017
Subjects: Peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1)
ventricles
action potential
wavelength
cardiac conduction
cardiac arrhythmias

description: A range of chronic clinical conditions accompany cardiomyocyte energetic dysfunction and constitute independent risk factors for cardiac arrhythmia. We investigated pro-arrhythmic and arrhythmic phenotypes in energetically deficient C57BL mice with genetic ablation of the mitochondrial promoter peroxisome proliferator activated receptor-γ coactivator-1β (Pgc-1β), a known model of ventricular arrhythmia. Pro-arrhythmic and cellular action potential (AP) characteristics were compared in intact Langendorff-perfused hearts from young (12-16 week) and aged (>52 week), WT and Pgc-1β-/- mice. Simultaneous electrocardiographic and intracellular microelectrode recordings were made through successive trains of 100 regular stimuli at progressively incremented heart rates. Aged Pgc-1β-/- hearts displayed an increased incidence of arrhythmia compared to other groups. Young and aged Pgc-1β-/- hearts showed higher incidences of alternans in both AP activation (maximum AP upshoot velocity (dV/dt)max and latency), recovery (action potential duration (APD90) and resting membrane potential (RMP)) characteristics compared to WT hearts. This was particularly apparent at lower pacing frequencies. These findings accompanied reduced (dV/dt)max and increased AP latency values in the Pgc-1β-/- hearts. APs observed prior to termination of the protocol showed lower (dV/dt)max and longer AP latencies, but indistinguishable APD90 and RMPs in arrhythmic compared to non-arrhythmic hearts. APD restitution analysis showed that Pgc-1β-/- and WT hearts showed similar limiting gradients. However, Pgc-1β-/- hearts had shortened plateau AP wavelengths, particularly in aged Pgc-1β-/- hearts. Pgc-1β-/- hearts therefore show pro-arrhythmic instabilities attributable to altered AP conduction and activation rather than recovery characteristics.
description: We acknowledge the financial support from the Medical Research Council (MR/M001288/1); the Wellcome Trust (105727/Z/14/Z); the British Heart Foundation (PG/14/79/31102 and PG/15/12/31280), Sudden arrhythmic death syndrome (SADS) UK; The McVeigh Benefaction and by the Fundamental Research Grant Scheme (FRGS/2/2014/SKK01/PERDANA/02/1), Ministry of Education, Malaysia.
Additional file 1 of Integrating temporal single-cell gene expression modalities for trajectory inference and disease prediction
Creators: name: Ranek, Jolene S.
name: Stanley, Natalie
name: Purvis, Jeremy E.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1. Supplementary Tables S1-S3 and Supplementary Figures S1-17.
Gα q Directly Activates p63RhoGEF and Trio via a Conserved Extension of the Dbl Homology-associated Pleckstrin Homology Domain
Creators: name: Gershburg, Svetlana
name: Kozasa, Tohru
name: Sondek, John
name: Rojas, Rafael J.
name: Kawano, Takeharu
name: Yohe, Marielle E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: The coordinated cross-talk from heterotrimeric G proteins to Rho GTPases is essential during a variety of physiological processes. Emerging data suggest that members of the Gα12/13 and Gαq/11 families of heterotrimeric G proteins signal downstream to RhoA via distinct pathways. Although studies have elucidated mechanisms governing Gα12/13-mediated RhoA activation, proteins that functionally couple Gαq/11 to RhoA activation have remained elusive. Recently, the Dbl-family guanine nucleotide exchange factor (GEF) p63RhoGEF/GEFT has been described as a novel mediator of Gαq/11 signaling to RhoA based on its ability to synergize with Gαq/11 resulting in enhanced RhoA signaling in cells. We have used biochemical/biophysical approaches with purified protein components to better understand the mechanism by which activated Gαq directly engages and stimulates p63RhoGEF. Basally, p63RhoGEF is autoinhibited by the Dbl homology (DH)-associated pleckstrin homology (PH) domain; activated Gαq relieves this autoinhibition by interacting with a highly conserved C-terminal extension of the PH domain. This unique extension is conserved in the related Dbl-family members Trio and Kalirin and we show that the C-terminal Rho-specific DH-PH cassette of Trio is similarly activated by Gαq.
(4061) Ann Crawford
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Umbraculum umbraculum (Gastropoda: Heterobranchia) spreading northwards: additional evidence to the tropicalization of the Bay of Biscay
Creators: name: ARIAS, Andrés
name: CROCETTA, Fabio
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2016

description: The occurrence of the subtropical and meridional heterobranch gastropod Umbraculum umbraculum is reported for the first time in the Bay of Biscay, from northern Spain, constituting its northernmost distribution in the eastern Atlantic to date. We present a detailed diagnosis and illustrations of the species in order to facilitate its identification. Furthermore, the potential implications of this finding are discussed.
title: A Global Environmental Scan of Assistive Technology Competency Standards: Protocol
Creators: name: Layton, Natasha
name: Callaway, Libby
name: Puli, Louise
name: Ekegren, Christina
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Medicine and Health Sciences
subject: Rehabilitation and Therapy
subject: assistive technology
subject: competency

description: A Global Environmental Scan of Assistive Technology Competency Standards: Protocol
Uniaxial anisotropy and low-temperature antiferromagnetism of Mn2BO4 single crystal
Creators: name: Kazak, N. V.
name: Platunov, M. S.
name: Knyazev, Yu. V.
name: Ivanova, N. B.
name: Bayukov, O. A.
name: Vasiliev, A. D.
name: Bezmaternykh, L. N.
name: Nizhankovskii, V. I.
name: Gavrilkin, S. Yu.
name: Lamonova, K. V.
name: Ovchinnikov, S. G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The Mn2BO4 single crystals have been grown using the flux technique. The careful study crystal structure and magnetic properties have been carried out. The antiferromagnet transition at TN = 26 K has been traced through the dc magnetization and specific heat temperature dependences. The magnetic uniaxial anisotropy has been detected with easy axis of magnetization lying in ab-plane. A reduction of the effective magnetic moment value is assigned to the non-quenched orbital moment of Jahn-Teller Mn3+ ions. Based on the superexchange interactions calculations the magnetic behavior is discussed.
description: 20 pages, 5 figures, 3 tables
Morphological variability of saccular otoliths in two populations of Liza ramada (Risso, 1810) (Mugilidae) in Tunisian lagoons (Bizerte and Ghar El Melh)
Creators: name: REBAYA, Manel
name: BEN FALEH, Abderraouf
name: ALLAYA, Hassen
name: KHEDHER, Maïssa
name: MARSAOUI, Bochra
name: CHALH, Abdellah
name: QUIGNARD, Jean-Pierre
name: TRABELSI, Monia
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2016

description: Otolith shape of sagittae is a valuable tool to evaluate the stock structure of fish species. The aim of this study was to investigate the stock discrimination for 120 specimens of the thin-lipped grey mullet Liza ramada (Risso, 1810) sampled from two Tunisian lagoons' stations (Bizerte and Ghar El Melh) for the first time. We analysed sagitta otolith shape variation of this species for both sexes and two sides (left-right otolith) for each specimen. Statistical and Discriminant Function Analysis for Sagitta shape clearly demonstrated statistically significant differences between the two different populations. These results were also confirmed by highly statistically significant differences between otoliths' shape (left and right) for both sexes. In addition, an asymmetry was detected when comparing otoliths of the same side (RR-LL) between different sampling sites. The shape variability of otolith between these two sampling sites is probably correlated with local environmental and ecological factors.
Broadband's Role in Agricultural Job Postings in U.S. Counties
Creators: name: Abney, Douglas John
Publisher: name: Purdue University Graduate School
Year: 2023
Subjects: Agricultural spatial analysis and modelling
Farm management, rural management and agribusiness

description: This study’s purpose is to examine the relationship between broadband and online agriculture job postings. While rural broadband has been a wide studied topic, little attention has been focused on broadband’s relationship to agricultural job demand. This research uses a spatial count model that estimates agriculture and digital agriculture jobs by U.S. counties. Data was collected using the Google Jobs API developed by SerpAPI. Job advertisements were collected monthly from June 2021 through June 2022 and again in November 2022. Digital agriculture jobs postings were extracted as a subset from the overall dataset. By searching for key terms in job advertisements, context analysis filtered and identified digital agriculture jobs. Digital agriculture job openings were identified in order to examine how broadband relates to data intensive jobs in agriculture. Jobs focused in digital agriculture require increased levels of technology and increased data throughput. We hypothesized that occurrences of digital agriculture job openings would likely be reliant on broadband. Broadband data in this study represents average download speeds, average upload speeds, the percentage of households with internet access, and the percentage of the population with internet speeds at and above 100 over 20 megabits per second. The approach for modeling this data requires a hurdle negative binomial regression model as our count data encountered many zero observations and suffered from overdispersion. Spatial effects were incorporated into the model to alleviate spatial autocorrelation and help define agricultural job openings among surrounding counties. Our findings support the funding of broadband policies in agriculture. While controlling for outside factors such as demographics and county production, we found that agriculture job openings were positively influenced by broadband. However, we determined that broadband metrics show no relationship with the presence of digital agriculture job openings likely due to rarity and potential seasonality in the data. This information aids as a steppingstone for increasing the knowledge of broadband’s impact on agriculture. This study may aid in supporting future studies that seek to define causal relationships between broadband and agriculture jobs.
Hepatic Overexpression of Glycerol- sn -3-phosphate Acyltransferase 1 in Rats Causes Insulin Resistance
Creators: name: Shulman, Gerald I.
name: Wang, Shuli
name: Torres, Tracy P.
name: Newgard, Christopher B.
name: Catlin, Re Etta L.
name: An, Jie
name: Cline, Gary W.
name: Shiota, Masakazu
name: Nagle, Cynthia A.
name: Liu, Zhen Xiang
name: Coleman, Rosalind A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Fatty liver is commonly associated with insulin resistance and type 2 diabetes, but it is unclear whether triacylglycerol accumulation or an excess flux of lipid intermediates in the pathway of triacyglycerol synthesis are sufficient to cause insulin resistance in the absence of genetic or diet-induced obesity. To determine whether increased glycerolipid flux can, by itself, cause hepatic insulin resistance, we used an adenoviral construct to overexpress glycerol-sn-3-phosphate acyltransferase-1 (Ad-GPAT1), the committed step in de novo triacylglycerol synthesis. After 5–7 days, food intake, body weight, and fat pad weight did not differ between Ad-GPAT1 and Ad-enhanced green fluorescent protein control rats, but the chow-fed Ad-GPAT1 rats developed fatty liver, hyperlipidemia, and insulin resistance. Liver was the predominant site of insulin resistance; Ad-GPAT1 rats had 2.5-fold higher hepatic glucose output than controls during a hyperinsulinemic-euglycemic clamp. Hepatic diacylglycerol and lysophosphatidate were elevated in Ad-GPAT1 rats, suggesting a role for these lipid metabolites in the development of hepatic insulin resistance, and hepatic protein kinase Cε was activated, providing a potential mechanism for insulin resistance. Ad-GPAT1-treated rats had 50% lower hepatic NF-κB activity and no difference in expression of tumor necrosis factor-α and interleukin-β, consistent with hepatic insulin resistance in the absence of increased hepatic inflammation. Glycogen synthesis and uptake of 2-deoxyglucose were reduced in skeletal muscle, suggesting mild peripheral insulin resistance associated with a higher content of skeletal muscle triacylglycerol. These results indicate that increased flux through the pathway of hepatic de novo triacylglycerol synthesis can cause hepatic and systemic insulin resistance in the absence of obesity or a lipogenic diet.
Coherence filtration under strictly incoherent operations
Creators: name: Liu, C. L.
name: Sun, C. P.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We study the task of coherence filtration under strictly incoherent operations in this paper. The aim of this task is to transform a given state $ρ$ into another one $ρ^\prime$ whose fidelity with the maximally coherent state is maximal by using stochastic strictly incoherent operations. We find that the maximal fidelity between $ρ^\prime$ and the maximally coherent state is given by a multiple of the $Δ$ robustness of coherence $R(ρ\|Δρ):=\min\{\uplambda|ρ\leq\uplambdaΔρ\}$, which provides $R(ρ\|Δρ)$ an operational interpretation. Finally, we provide a coherence measure based on the task of coherence filtration.
description: 6 pages. arXiv admin note: text overlap with arXiv:2206.04208
Contributions to the autoecology and biogeography of some psammic species of Annelida Polychaeta from Galicia (North-West Iberian Peninsula)
Creators: name: BESTEIRO, Celia
name: EUGÊNIO, Wilma
name: CARVALHO, Luiz Henrique
name: VEIGA, Purificación
name: RUBAL, Marcos
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2016

description: As a result of a more wide project guided to characterize the interstitial fauna of the Galician coasts (NW Iberian Peninsula), we present in this work six species of polychaetous annelids from the intertidal area of this coast. Microphthalmus listensis Westheide, 1967, Protodrilus purpureus (Schneider, 1868) and Protodriloides symbioticus (Giard, 1904) are recorded for the first time in the littoral of the Iberian Peninsula and Microphthalmus similis Bobretzky, 1870 is mentioned for the first time in the Galician coasts. Also, two species are mentioned for the first time in the intertidal zone: Eulalia venusta Saint-Joseph, 1888 and Raphidrilus nemasoma Monticelli, 1910. Their biotope and geographical distribution are discussed and compared with data from the literature.
Pointwise best approximation results for Galerkin finite element solutions of parabolic problems
Creators: name: Leykekhman, Dmitriy
name: Vexler, Boris
Publisher: name: arXiv
Year: 2015
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: In this paper we establish a best approximation property of fully discrete Galerkin finite element solutions of second order parabolic problems on convex polygonal and polyhedral domains in the $L^\infty$ norm. The discretization method uses of continuous Lagrange finite elements in space and discontinuous Galerkin methods in time of an arbitrary order. The method of proof differs from the established fully discrete error estimate techniques and for the first time allows to obtain such results in three space dimensions. It uses elliptic results, discrete resolvent estimates in weighted norms, and the discrete maximal parabolic regularity for discontinuous Galerkin methods established by the authors in [16]. In addition, the proof does not require any relationship between spatial mesh sizes and time steps. We also establish a local best approximation property that shows a more local behavior of the error at a given point.