cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Scymnus micros Fauvel
Creators: name: Nattier, Romain
name: Jourdan, Hervé
name: Mille, Christian
name: Chazeau, Jean
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Coccinellidae
Scymnus
Scymnus micros

description: Scymnus micros Fauvel
Scymnus micros Fauvel, 1903: 324 (pars).
Endemic to New Caledonia (Nouméa). In his review, Bielawski (1973) assigned a lectotype for this species, which represents the only known specimen in collections (Col d’Amieu, dense rain forest). In Fauvel’s collection, this species was partially confused with Stethorus vagans (Blackburn) (Chazeau 1979). At the genus level, its position remains uncertain. Male genitalia and the heavily convex specimen habitus suggest a Sticholotidini. Its biology remains unknown.
description: Published as part of Nattier, Romain, Jourdan, Hervé, Mille, Christian & Chazeau, Jean, 2015, An annotated checklist of the Coccinellidae (Coleoptera) from New Caledonia, pp. 301-331 in Zootaxa 4058 (3) on page 319, DOI: 10.11646/zootaxa.4058.3.1, http://zenodo.org/record/236980
Mechanism of DNA break repair in germline cells
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cigarette smoking is the number one cause of lung cancer. In addition to nicotine, there are about 100 more ingredients present in a cigarette, 20 of which are carcinogens, substances that cause cancer. Many of these substances are known to inflict breaks in DNA, the blueprint of life. Failure to repair such discontinuities in DNA has been strongly linked to tumor formation, including lung cancer. Here, I propose to uncover the molecular mechanism of the repair of this damage to DNA. My laboratory is at the forefront of studying double strand DNA break repair via homologous recombination, a process that ensures faithful repair of such breaks. Over the last 25 years, we have purified and characterized a number of components of this machinery, many of which have been tied to cancer. Using biochemical and biophysical tools developed in our laboratory, I propose to study two crucial components of this pathway. I choose to study these two proteins (Dmc1 and Rdh54) because they are vital for error-free recombination in germline cells, cells that are involved in reproduction. Recombination in germline cells initiates by the infliction of programmed DNA breaks, and a failure to repair such breaks are a major cause of miscarriages, still-births and cancer. Importantly, there is a strong correlation between smoking and miscarriages as well childhood cancer, thereby making the proposed work highly relevant to fatalities associated with smoking. My approach of studying the process at its fundamental level will provide deep insights into the mechanism of homologous recombination. A complete understanding of this process is necessary for developing potential targets that would help to eradicate the lethal effect of smoking-induced diseases. My study has the added benefit of not requiring human subjects or the sacrifice of model animals.
Alpha4* Nicotinic Receptor in Dopaminergic System
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Nicotine is the compound in tobacco that causes addiction. Nicotine activates nicotinic acetylcholine receptors (nAChRs) widely expressed in the brain, and causes the behaviors of nicotine addiction. Mesolimbic and nigrostriatal dopamine systems are important brain areas for these events. Chronic nicotine exposure results in long-term alterations in these brain areas, and these alterations may underlie the diffuclties in smoking cessation. This project seeks to understand the alterations in both nigrostriatal and mesolimbic dopamine systems following chronic nicotine exposure. There are several subtypes of nAChRs in the brain. Among them, the nAChRs containing alpha4beta2 subunits are the most abundant nAChRs in these two dopamine systems, and are activated by nicotine at the concentrations as low as in cerebrospinal fluid of smokers (0.1 - 1 microM). In previous experiments, a fluorescent protein (YFP) was introduced into the alpha4 nAChR subunit. Then, an alpha4-YFP knock-in mouse line was generated. This mouse line facilitates the visualization of nAChRs containing alpha4 subunit in the brain. The data showed that nAChRs containing the alpha4 subunit are upregulated in both number and function by chronic nicotine exposure in both nigrostriatal and mesolimbic dopamine systems. Interestingly, the upregulation specifically occurs in certain cell types in these systems. This project will examine the functional changes following the upregulation of alpha4 nAChRs at both the cellular and the neuronal circuitry levels. If funded and successful, this project will broaden our knowledge of physiological alterations induced by chronic nicotine exposure. Preventing or reversing may partially or fully disrupt nicotine addiction, which would be valuable for designing therapeutic strategies for nicotine cessation.
Oxygen Transport Following Lung Transplantation in COPD
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Patients presenting with severe chronic obstructive pulmonary disease (COPD) are typically characterized by having shortness of breath and are thus limited in their activities of daily living which often leads to a poor quality of life. Studies demonstrate that lung transplantation improves the patient’s pulmonary mechanics and gas exchange parameters; however, exercise capacity remains substantially reduced. Although it has been suggested that skeletal muscle dysfunction may contribute to a reduced exercise tolerance postoperatively, the underlying mechanism has yet to be elucidated. While the ability to sustain aerobic exercise is multifactorial (i.e., cardiac function, muscle blood flow, and/or hemoglobin concentration), it is primarily dependent on oxygen supply and the ability of oxygen to diffuse from the red blood cells to the muscle mitochondria.

 Vital to this process is the role of capillary development. Thus, the adaptation of skeletal muscle to aerobic training includes the development of new capillaries from existing capillaries in a process called angiogenesis. Studies have demonstrated that angiogenesis is initiated by vascular endothelial growth factor (VEGF) which is located on chromosome 6p21.3 in humans. VEGF165, the most common isoform, is involved in vascular permeability, endothelial cell proliferation, and angiogenesis. Thus, any examination of reduced exercise tolerance in post transplant COPD patients, must consider the role of capillary development/maintenance and specifically, VEGF.

 Lung transplant patients, therefore, present a unique opportunity to examine the role of skeletal muscle dysfunction preoperatively and postoperatively as well as to test the interaction between immunosuppressives and capillary development/maintenance. The research proposed in this application is significant, because it is expected to provide that knowledge related to immunosuppressives and their interaction with capillary development/maintenance (i.e. VEGF) which is currently lacking in the literature. This is expected to have a significant positive impact on the understanding of angiogenesis in skeletal muscle of post transplant COPD patients, and as a consequence, provide insight into the skeletal muscle dysfunction observed postoperatively in COPD patients.
Liolaemus pagaburoi Lobo & Espinoza 1999
Creators: name: Pincheira-Donoso, Daniel
name: Scolaro, J. Alejandro
name: Sura, Piotr
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Liolaemidae
Liolaemus
Liolaemus pagaburoi

description: Liolaemus pagaburoi Lobo & Espinoza
Liolaemus alticolor alticolor Cei 1993: 282 (in part).
Liolaemus pagaburoi Lobo & Espinoza 1999: 131 (type locality: Abra de El Infiernillo, Provincial Road 307, Tafí del Valle Department, Tucumán Province, Argentina); Etheridge & Espinoza 2000: 8; Lobo 2001: 139; Martínez-Oliver & Lobo 2002: 50; Lobo & Espinoza 2004: 852; Chebez et al. 2005: 34; Sura 2005: 429; Díaz & Lobo 2006: 265; Díaz 2007: 113.
description: Published as part of Pincheira-Donoso, Daniel, Scolaro, J. Alejandro & Sura, Piotr, 2008, A monographic catalogue on the systematics and phylogeny of the South American iguanian lizard family Liolaemidae (Squamata, Iguania), pp. 1-85 in Zootaxa 1800 on page 29, DOI: 10.5281/zenodo.6789337
Scymnus (Scymnus) cochereaui Bielawski
Creators: name: Nattier, Romain
name: Jourdan, Hervé
name: Mille, Christian
name: Chazeau, Jean
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Coccinellidae
Scymnus
Scymnus cochereaui

description: Scymnus (Scymnus) cochereaui Bielawski
Scymnus (Scymnus) cochereaui Bielawski, 1973: 403.
Endemic to New Caledonia, this species is only known from the type series (holotype and two paratypes, Nouméa, on coconut tree). No information is available on its biology and feeding ecology.
Material examined. NEW CALEDONIA: Nouméa, on coconut, viii.1968 (P. Cochereau rec.) (MNHN).
description: Published as part of Nattier, Romain, Jourdan, Hervé, Mille, Christian & Chazeau, Jean, 2015, An annotated checklist of the Coccinellidae (Coleoptera) from New Caledonia, pp. 301-331 in Zootaxa 4058 (3) on page 319, DOI: 10.11646/zootaxa.4058.3.1, http://zenodo.org/record/236980
Targeting anti-apoptotic Bcl-2 family members in lung cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: According to the National Cancer Institute, lung cancer is the leading cancer-related cause of death in both men and women in the United States, accounting for approximately one third of all cancer-related deaths. Despite efforts in prevention and research, it is estimated that $9.6 billion is spent country-wise each year on treatment, and the survival rate is of only 15% after 5 years. Part of the problem is related to the absence of well-established methods for diagnostics, and thus most cases of lung cancer are diagnosed in advanced stages. Additionally, most lung cancers exhibit minimal sensitivity to or rapidly acquire resistance to radio- and chemotherapy. Therefore, the development of more efficient therapies is necessary.

 In this proposal, we aim to study two anti-death proteins, Bcl-B and Bfl-1, which are frequently over-produced in lung cancers, as well as some other types of cancers frequently associated with tobacco abuse. The Bcl-B and Bfl-1 proteins are involved in the body’s natural mechanism for controlling cell death, also known as apoptosis. Under normal conditions, these proteins protect the cells against stress but lung cancer cells subverted this function by producing large amounts of these proteins in order to survive as their behavior becomes progressively deranged from accumulation of genetic mutations caused by carcinogens in tobacco. Several lines of investigation have shown that these anti-death proteins are also causatively involved in radio- and chemoresistance and that new drugs capable of targeting Bcl-B and Bfl-1 have the potential to sensitize tumors to death in combination with lower doses of current drugs, thus promising of improved anti-tumor efficacy with fewer side effects.

 To develop new chemical inhibitors that neutralize Bcl-B and Bfl-1, we propose to solve the three-dimensional structures of these proteins by either X-ray crystallography or Nuclear Magnetic Resonance methods. These methods have the potential to uncover details about these protein molecules, allowing for the design of new drugs to inactivate them and promote killing of cancer cells. The project I propose involves a multi-disciplinary collaboration, with involvement of experts in structural biology, tumor cell biology, protein biochemistry, and chemistry, towards a collective goal of generating more effective therapies that restore tumor sensitivity to natural mechanisms for cell eradication and that therefore provide new ways to combat lung cancer and other cancers associated with tobacco use.
Inhibition of MYC-activated gene expression by polyamides
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The largest single cause of cancer death in the United States is tobacco use. It is estimated that approximately 1.4 million people will be newly diagnosed with cancer in 2006; with California residents encompassing 10% of those affected. In both men and women, mortality rates are the highest in patients suffering from lung cancer- a disease which has been unambiguously linked to tobacco smoking. In fact, a recent analysis of small cell lung cancer patients revealed more than 95% were tobacco smokers. Consequently, new and more efficacious treatments for lung and related cancers are highly warranted. A common defect found in small cell lung cancer, and many other cancers, is deregulated activity of a gene termed MYC (also know as MYC oncogene). The MYC oncogene encodes the MYC protein; hence, a high level of MYC oncogene activity yields a high level of MYC protein in cells. Elevated MYC protein levels are present in many small cell lung cancers and increasingly prevalent during progression of the disease following chemotherapy. Unfortunately, elevated MYC protein levels are deleterious to cells. The MYC protein functions in cells as a transcription factor- a protein involved in "turning on" other genes. Hence, high levels of MYC protein facilitates "turning on" a bevy of other genes. Such actions are harmful to cells in a variety of ways, such as promoting uncontrolled cell growth- a hallmark trait of cancer. In this proposal we aim to circumvent the effects of elevated MYC protein levels in cells with a designed molecule- a polyamide. Polyamides are small molecules (like drugs) that enter into cells and influence cellular processes by interacting with DNA. In this application, a small family of related polyamides has been designed to: (i) enter into cells, (ii) find the region of DNA that MYC binds to "turn on" genes, and (iii) block the ability of MYC to "turn on" genes, thereby regulating its activity. Unlike other approaches that abolish the formation of functional MYC protein in cells, our approach simply inhibits the ability of MYC to haphazardly "turn on" genes. We hypothesize this may be therapeutically useful since some genes require functional MYC protein to repress (instead of activate) their activity. In addition to preparing the proposed polyamides, we will evaluate their ability to block gene activation by MYC, and study their potential in cells as anticancer therapeutics. If successful, this project has the potential to uncover a new avenue in the development of novel, targeted cancer therapies for treating human cancer.
Liolaemus paulinae Donoso-Barros 1961
Creators: name: Pincheira-Donoso, Daniel
name: Scolaro, J. Alejandro
name: Sura, Piotr
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Liolaemidae
Liolaemus
Liolaemus paulinae

description: Liolaemus paulinae Donoso-Barros
Liolaemus paulinae Donoso-Barros 1961a: 387 (type locality: Rio Loa, Calama, El Loa Province, Antofagasta Region, Chile), 1966a: 189, 1970a: 192; 1970b: 98; Vanzolini 1986: 16; Veloso & Navarro 1988: 509; Laurent 1992: 32; Núñez & Jaksic 1992: 74; Etheridge 1995: 33; Etheridge & Espinoza 2000: 8; Lobo 2001: 139; Núñez & TorresMura 2002: 27; Sura 2005: 429; Díaz & Lobo 2006: 264.
Liolaemus (Liolaemus) paulinae Pincheira-Donoso 2005: 124; Pincheira-Donoso & Núñez 2005: 225.
description: Published as part of Pincheira-Donoso, Daniel, Scolaro, J. Alejandro & Sura, Piotr, 2008, A monographic catalogue on the systematics and phylogeny of the South American iguanian lizard family Liolaemidae (Squamata, Iguania), pp. 1-85 in Zootaxa 1800 on page 29, DOI: 10.5281/zenodo.6789337
Effect of Oxidation on Rate of ApoA-I - HDL Exchange
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Tobacco smoke exposure is a major risk factor for cardiovascular diseases. One of the reasons why tobacco smoke can cause deleterious effects on the circulatory system is because of the chronic inflammation state that affects smokers. This inflammatory burden is a major cause of atherosclerosis in smokers. Chronic inflammation gives rise to the expression of enzymes which produce highly oxidative compounds as part of an immune response regimen. Myeloperoxidase (MPO) is the primary enzyme involved in this process. The reactive compounds generated by activated MPO damage proteins and lipids and by this contributes to the initiation and progression of atherosclerosis. High density lipoprotein (HDL - the "good" cholesterol) is an important anti-atherogenic factor but interestingly a target of MPO-mediated oxidation. These particles normally transport insoluble lipids and cholesterol in the bloodstream to the liver, thanks to the unique properties of a protein called apolipoprotein A-I (apoA-I). If the normal function of apoA-I and HDL is affected, excess cholesterol can accumulate in the walls of blood vessels promoting atherosclerosis. Since oxidized high density lipoprotein are found in the site of atherosclerosis lesions and oxidation of HDL impairs its anti-atherogenic function of cholesterol transport, it can be concluded that tobacco smoke-induced oxidation of HDL constitute a contributing factor to progression of atherosclerosis. The goal of our research is to investigate the molecular mechanism underlying the atherogenic effects of oxidative stress, namely those arising from long term exposure to tobacco smoke. The central hypothesis of this proposal is that oxidative modification of HDL in tobacco smokers is a major contributor to the development of atherosclerosis and, in particular, that oxidation of apoA-I in HDL, impairs its ability of efficiently uptake and release lipid and cholesterol. To test this hypothesis we have recently developed a fluorescence-based assay to measure in real time apoA-I exchange rates on and off HDL. Thanks to this innovative assay we will test the effect of MPO induced oxidation on the rate of exchange of apoA-I on and off HDL. Using variations of apoA-I that are resistant to oxidation, we will determine whether oxidation resistance imparts retention of exchangeability on and off HDL. Findings obtained from this research will significantly contribute to understanding the molecular mechanism linking tobacco smoke-related oxidative stress and its associated cardiovascular diseases and will be useful in the design of therapeutic strategies to decrease lipoprotein damage caused by tobacco smoke exposure.
Additional file 11: of Hospital acquired Acute Kidney Injury is associated with increased mortality but not increased readmission rates in a UK acute hospital
Creators: name: Nerissa Jurawan
name: Pankhurst, Tanya
name: Ferro, Charles
name: Nightingale, Peter
name: Coleman, Jamie
name: Rosser, David
name: Ball, Simon
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy
subject: Computational Biology

description: Univariable and restricted multivariable analyses by Cox regression, for CRP effect on inpatient mortality, 90Â day mortality and mortality beyond 90Â days. (DOCX 33Â kb)
Impact of Positive Mood on Self-Control Depletion in Smoking
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Despite the risks associated with smoking, many people are worried about gaining weight if they quit. These concerns may lead to dieting while attempting to quit smoking, however research has shown that dieting may actually damage attempts to quit smoking. The current study uses a ground-breaking new model of self-control to examine why dieting may in fact damage attempts to control smoking. More importantly, we test a brief intervention strategy to help people who want to manage their weight while trying to quit smoking.

 The self-control strength model suggests that people have a limited supply of self-control to use for various acts that require willpower, such as resisting temptations. Using self-control on one task (dieting) may use up part of this strength, and thus weaken later attempts to use self-control (quit smoking). That is why dieting (e.g., resisting tempting foods) may damage attempts to resist smoking. However, this study will examine the potential restorative effect positive emotions have on people’s self-control strength so that they can successfully engage in both dietary restraint and resisting the urge to smoke. Previous studies demonstrate that positive emotions are related to positive health outcomes, such as less risk of stroke, and fewer instances of death among HIV+ patients. In this study we will test the effect of positive emotions on smoking behavior using a randomized controlled trial design experiment in a controlled laboratory setting.

 This experiment serves as a scientific foundation designed to be applied to clinical interventions for people who want to quit smoking. This responds to the mission of the TRDRP, which supports the development of more effective treatments for smoking cessation. This type of treatment tool could be beneficial for individuals who desire to quit smoking and at the same time diet in order not to gain weight. The benefits to society could be immense, if people who would normally refuse to quit smoking because they are worried about gaining weight, had the option of this type of intervention strategy that allows them to address both issues.
Use of Marker Genes to evaluate the stress situation of Klebsormidium species in Biological Soil crusts from Antarctica – A case study to prove the concept
Creators: name: Palaniappan, Deepamalini
name: Prof. Dr.  Becker, Burkhard
name: Prof. Dr.  Dörmann, Peter
Publisher: name: Zenodo
Year: 2024

description: Supplementary data for the master's thesis titled 'Use of Marker Genes to Evaluate the Stress Situation of Klebsormidium Species in Biological Soil Crusts from Antarctica – A Case Study to Prove the Concept.' These files provide a detailed explanation of the manual analysis conducted to identify marker genes across three sampling sites.
Liolaemus petrophilus Donoso-Barros & Cei
Creators: name: Pincheira-Donoso, Daniel
name: Scolaro, J. Alejandro
name: Sura, Piotr
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Liolaemidae
Liolaemus
Liolaemus petrophilus

description: Liolaemus petrophilus Donoso-Barros & Cei
Liolaemus elongatus petrophilus Donoso-Barros & Cei 1971: 94 (type locality: between Laguna Raimundo and Laguna Chara, Meseta de Somuncurá, Río Negro Province, Argentina); Cei 1973c: 1, 1974b: 224, 1986: 245; Vanzolini 1986: 14; Laurent 1992: 31; Etheridge 1995: 33.
Liolaemus petrophilus Espinoza et al. 2000: 508; Etheridge & Espinoza 2000: 8; Avila et al. 2003: 534; Chebez et al. 2005: 34; Scolaro 2005: 45; Sura 2005: 429; Díaz & Lobo 2006: 264.
description: Published as part of Pincheira-Donoso, Daniel, Scolaro, J. Alejandro & Sura, Piotr, 2008, A monographic catalogue on the systematics and phylogeny of the South American iguanian lizard family Liolaemidae (Squamata, Iguania), pp. 1-85 in Zootaxa 1800 on page 29, DOI: 10.5281/zenodo.6789337
Additional file 1 of Testing novel strategies for patients hospitalised with HIV-associated disseminated tuberculosis (NewStrat-TB): protocol for a randomised controlled trial
Creators: name: Namale, Phiona E.
name: Boloko, Linda
name: Vermeulen, Marcia
name: Haigh, Kate A.
name: Bagula, Fortuna
name: Maseko, Alexis
name: Sossen, Bianca
name: Lee-Jones, Scott
name: Msomi, Yoliswa
name: McIlleron, Helen
name: Mnguni, Ayanda Trevor
name: Crede, Thomas
name: Szymanski, Patryk
name: Naude, Jonathan
name: Ebrahim, Sakeena
name: Vallie, Yakoob
name: Moosa, Muhammed Shiraz
name: Bandeker, Ismail
name: Hoosain, Shakeel
name: Nicol, Mark P.
name: Samodien, Nazlee
name: Centner, Chad
name: Dowling, Wentzel
name: Denti, Paolo
name: Gumedze, Freedom
name: Little, Francesca
name: Parker, Arifa
name: Price, Brendon
name: Schietekat, Denzil
name: Simmons, Bryony
name: Hill, Andrew
name: Wilkinson, Robert J.
name: Oliphant, Ida
name: Hlungulu, Siphokazi
name: Apolisi, Ivy
name: Toleni, Monica
name: Asare, Zimkhitha
name: Mpalali, Mkanyiseli Kenneth
name: Boshoff, Erica
name: Prinsloo, Denise
name: Lakay, Francisco
name: Bekiswa, Abulele
name: Jackson, Amanda
name: Barnes, Ashleigh
name: Johnson, Ryan
name: Wasserman, Sean
name: Maartens, Gary
name: Barr, David
name: Schutz, Charlotte
name: Meintjes, Graeme
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Supplementary Material 1.
Scaptomyza Hardy
Creators: name: Sinclair, Bradley J.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Scaptomyza

description: Genus Scaptomyza Hardy
(undetermined subgenus)
undetermined species
Distribution. Not determined. Galápagos: Santa Cruz.
Remarks. Adults of this species were reared from leaf mines in Scalesia species and Iochroma ellipticum (Hook.f.) Hunz.
description: Published as part of Sinclair, Bradley J., 2023, An annotated checklist of the Diptera of the Galápagos Archipelago (Ecuador), pp. 1-102 in Zootaxa 5283 (1) on page 58, DOI: 10.11646/zootaxa.5283.1.1, http://zenodo.org/record/7912667
Additional file 1: of Hospital acquired Acute Kidney Injury is associated with increased mortality but not increased readmission rates in a UK acute hospital
Creators: name: Nerissa Jurawan
name: Pankhurst, Tanya
name: Ferro, Charles
name: Nightingale, Peter
name: Coleman, Jamie
name: Rosser, David
name: Ball, Simon
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Science Policy
subject: Computational Biology

description: Medications within respective drug classes. (DOCX 14Â kb)
Benthana cairensis Sokolowicz, Araujo and Boelter 2008
Creators: name: Aguiar, Ivanklin Soares Campos-Filho Giovanna Monticelli Cardoso José Otávio
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Isopoda
Philosciidae
Benthana
Benthana cairensis

description: 41. Benthana cairensis Sokolowicz, Araujo and Boelter, 2008
Benthana cairensis Sokolowicz, Araujo and Boelter, 2008: 315, figs. 1–28. – Costa et al., 2014: 173, fig. 3. – Campos-Filho et al., 2015b: 53, fig. 33D. – Zimmermann et al., 2015a: 3, Tab. 1.
Distribution. Endemic to Brazil (states of São Paulo, Paraná, Santa Catarina and Rio Grande do Sul) (Campos-Filho et al., 2015b; Zimmermann et al., 2015a).
description: Published as part of Aguiar, Ivanklin Soares Campos-Filho Giovanna Monticelli Cardoso José Otávio, 2018, Catalogue of terrestrial isopods (Crustacea, Isopoda, Oniscidea) from Brazil: an update with some considerations, pp. 1-40 in Nauplius (e 2018038) (e 2018038) 26 on page 9, DOI: 10.1590/2358-2936e2018038, http://zenodo.org/record/14666839
Scymnus (Caledonus) angusticollis Fauvel
Creators: name: Nattier, Romain
name: Jourdan, Hervé
name: Mille, Christian
name: Chazeau, Jean
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Coccinellidae
Scymnus
Scymnus angusticollis

description: Scymnus (Caledonus) angusticollis Fauvel
Scymnus angusticollis Fauvel, 1903: 323.
Scymnus (Caledonus) angusticollis: Bielawski 1973: 397.
This species was redescribed by Bielawski (1973), who established an endemic subgenus Caledonus. It is known only from the west coast region (around Nouméa and Dumbéa—Chazeau pers. obs, and Col de Tonghoué). No information is available on its biology.
Literature records. NEW CALEDONIA: Tonghoué, i (A. Fauvel rec.) (coll. A. Fauvel in IRSNB) (Bielawski 1973).
description: Published as part of Nattier, Romain, Jourdan, Hervé, Mille, Christian & Chazeau, Jean, 2015, An annotated checklist of the Coccinellidae (Coleoptera) from New Caledonia, pp. 301-331 in Zootaxa 4058 (3) on page 319, DOI: 10.11646/zootaxa.4058.3.1, http://zenodo.org/record/236980
Zaprionus indianus Gupta 1970
Creators: name: Sinclair, Bradley J.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Drosophilidae
Zaprionus
Zaprionus indianus

description: indianus Gupta
Zaprionus indianus Gupta, 1970: 63.
Zaprionus species: Causton & Sevilla 2007: 145 [introduced species].
Distribution. Introduced. Cosmopolitan. Galápagos: San Cristóbal (ICCDRS), Santa Cruz.
Remarks. This species was first recorded on the basis of a single specimen collected in a McPhail trap in Puerto Ayora in January 2006. It has been reared on a wide variety of fruits as well as in tortoise dung (Lehnen et al. unpubl.). Elsewhere, this species is often associated with damaged or fallen rotting fruit, as well as a commercial pests of many tropical fruits (Van der Linde et al. 2006).
description: Published as part of Sinclair, Bradley J., 2023, An annotated checklist of the Diptera of the Galápagos Archipelago (Ecuador), pp. 1-102 in Zootaxa 5283 (1) on page 58, DOI: 10.11646/zootaxa.5283.1.1, http://zenodo.org/record/7912667
Liolaemus pictus
Creators: name: Pincheira-Donoso, Daniel
name: Scolaro, J. Alejandro
name: Sura, Piotr
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Liolaemidae
Liolaemus
Liolaemus pictus

description: Liolaemus pictus (Duméril & Bibron)
Proctotretus pictus Duméril & Bibron 1837: 276.
Content: Five subspecies occuring in the austral forests of Argentina and Chile, including the archipelago of Chiloé in the last country (Donoso-Barros 1966a; Cei 1986; Pincheira-Donoso & Núñez 2005).
description: Published as part of Pincheira-Donoso, Daniel, Scolaro, J. Alejandro & Sura, Piotr, 2008, A monographic catalogue on the systematics and phylogeny of the South American iguanian lizard family Liolaemidae (Squamata, Iguania), pp. 1-85 in Zootaxa 1800 on page 29, DOI: 10.5281/zenodo.6789337
Variant-aware Reconfiguration of Automotive Virtual Test Environments
Creators: name: Seidel, Luca
name: Guissouma, Houssem
name: Schmid, Andreas
name: Sax, Eric
Publisher: name: Karlsruher Institut für Technologie (KIT)
Year: 2024
Subjects: Virtual Test Environment
Driving Simulation
Variant Management
Reconfiguration
Automotive
23rd Driving Simulation and Virtual Reality Conference and Exhibition (DSC) Straßburg
18th-20th September 2024

description: Modern vehicles offer a multitude of features, adapting to individual preferences. Addressing the challenge of efficiently testing a wide range of automotive system variants within a virtual test environment is crucial in the face of the growing complexity of these vehicles. With numerous configuration options and frequent software updates, there's a pressing need for a standardized approach to variant-aware reconfiguration.
In response to this challenge, we propose a delta-based reconfiguration of a virtual test environment with modular components. This reconfiguration process allows a dynamic and efficient adaption based on selected features of the module under test. Leveraging feature models, we define relationships between features and their impact on the mut and test environment configuration.
Our paper introduces a concept for variant-aware reconfiguration. This concept utilizes a 150% model, representing a superset of a module containing all necessary assets to derive any variant. Additionally, we employ delta analysis to reduce reconfiguration efforts by identifying only the necessary adjustments based on changes in selected features.
Novel biomarkers and chemoprevention approaches for SCLC
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Lung cancer is the leading cause of cancer deaths worldwide, with more than 1.3 million deaths every year. Small cell lung cancer (SCLC) is a subtype of lung cancer that comprises ~15% of all lung cancers and results in over 200,000 deaths worldwide each year. Most people diagnosed with SCLC have a history of heavy smoking, which strongly correlates tobacco use with this cancer. Unfortunately, SCLC has a very poor prognosis, with a 5-year survival rate of less than 5%.

 Our overarching goal is to gain a better understanding of the mechanisms underlying the development of SCLC. It is our belief that we will be able to use this knowledge to eventually design new and improved diagnosis and treatment options for this deadly cancer. To achieve this goal, we use a two-pronged approach: first, we have developed a mouse model for human SCLC in which mice are genetically engineered and manipulated to grow lung cancer that is very similar to human SCLC. In parallel, in a back-and-forth strategy with the mouse model, we use tumor samples and cell lines from SCLC patients.

 Here, our specific goals are to discover and validate biomarkers for SCLC and to identify novel chemoprevention approaches for SCLC. To this end, we have employed an integrative bioinformatics approach to identify drugs known to efficiently treat other diseases that may work in SCLC based on the gene expression profiles of these tumors. We surmise that the targets of these drugs may be biomarkers for SCLC; these candidate biomarkers will be tested in mice and on human samples, with the hope that they will rapidly be used in the clinic for diagnosis and early detection of SCLC. In addition, the drugs identified through our bioinformatics pipeline will be tested on the mutant mice developing SCLC to determine if these drugs may be used to prevent the development and progression of SCLC.
Alpha4beta2 nAChR upregulation in the perforant pathway
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Nicotine, a psychostimulant present in tobacco that likely underlies addictive smoking behavior, binds to nicotinic acetylcholine receptors (nAChRs) in the central nervous system, initiating addiction. Activation of these ligand-gated ion channels by their endogenous agonist, acetylcholine (ACh), results in membrane depolarization and cellular excitation. Chronic exposure to nicotine upregulates the high-affinity alpha4beta2 nAChR subtype that has been implicated in addictive behavior in a cellular- and subcellular compartment-specific manner. These receptors are upregulated rapidly during nicotine exposure, reaching approximately half-maximal upregulation within a day. Thus, following even brief nicotine exposure, the expression of nAChRs within the brain is altered in specific pathways.

 The hippocampus is a structure important for learning and memory that has been implicated in the cognitive effects of nicotine and in addiction. Principal neurons within the hippocampus are place cells that encode an animal’s position within its environment and may also fire in response to non-spatial cues, such as the presence or absence of an object or reward. The place fields of these cells are thought to arise from integration of the inputs from the principal cells in layers II and III of entorhinal cortex (grid cells). Alpha4beta2 nAChRs are located on the axons of medial perforant pathway, which projects from the layer II cells in medial entorhinal cortex to the dentate gyrus, and on the temporoammonic pathway, which is the direct projection from layer III cells in medial entorhinal cortex to the CA1 region, and following chronic nicotine treatment there is an upregulation of alpha4-containing nAChRs in the medial perforant pathway. Thus, the alpha4beta2 nAChRs are posed to influence the integration of this information and, following nicotine treatment, upregulation of these receptors may alter this.

 We can visualize these receptors using fluorescently tagged knock-in mice and determine the exact location of the receptors and whether this is altered after nicotine treatment. Additionally, we can use in vivo electrophysiology to determine how upregulating these receptors impacts the function of hippocampal place cells, the post-synaptic targets of the pathways containing the receptors, and grid cells in entorhinal cortex (which may have upregulated receptors somatodendritically as well as on the axonal projections). This study will determine how nicotine treatment and the subsequent upregulation of alpha4beta2 nAChRs on specific pathways within the hippocampus can modulate hippocampal activity.
Acipenser huso Linnaeus 1758
Creators: name: Linnaei, Caroli
Publisher: name: Zenodo
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Amphibia
Nantes
Acipenseridae
Acipenser
Acipenser huso

description: Huso.
3. A. cirris 4? corpore nudo.
Art. gen. 65. syn. 92. Acipenser tuberculis carens.
Habitat in Danubio, fluviisque Imperii Ruthenici.
Alii cirro: 4, alii 8 tradunt in nobis non vi s o. Corium pro linei: curruum prae stantissimum, ab eo Ichtlıyocolla praeparatur & ex ovis Garum consicitur.
description: Published as part of Linnaei, Caroli, 1758, Regnum Animale, pp. 1-65 in Systema Naturae 1 on page 238, DOI: 10.5281/zenodo.14648402
Acipenser plecostomus Linnaeus 1758
Creators: name: Linnaei, Caroli
Publisher: name: Zenodo
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Amphibia
Nantes
Acipenseridae
Acipenser
Acipenser plecostomus

description: Plecostmus.
-
4. A. cirris duobus. Mu s. Ad. Fr. 1. p. 55. t. 28. f. 4.Gron.mus1.n. 67.t. 3.f. 1,2. Plecostomus
dorsodipterygio, cirris duobus, cauda bifurca.
Habitat Surinami.
Pinnae D. 8,1. P 4,. V 6. A. 5. C. 12.
Acipenseres vivipari (*) sunt, uti Petromyzon.
description: Published as part of Linnaei, Caroli, 1758, Regnum Animale, pp. 1-65 in Systema Naturae 1 on page 238, DOI: 10.5281/zenodo.14648402
Scymnus (Pullus) unicolor Montrouzier
Creators: name: Nattier, Romain
name: Jourdan, Hervé
name: Mille, Christian
name: Chazeau, Jean
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Coccinellidae
Scymnus
Scymnus unicolor

description: Scymnus (Pullus) unicolor (Montrouzier)
Epilachna unicolor Montrouzier, 1861: 306.
Epilachna emarginata: Montrouzier, 1864: 219. Scymnus unicolor: Fauvel 1903: 323.
Scymnus (Pullus) unicolor: Korschefsky 1931: 149.
Endemic to New Caledonia, this species has been recorded from both coasts (Nouméa, Canala), Isle of Pines and Lifou (Loyalty Islands) (Chazeau, pers. obs.). No information is available on its biology.
Literature records. NEW CALEDONIA: Nouméa (Delauney rec.) (coll. Fleutiaux in MNHN); Isle of Pines (coll. A. Fauvel in IRSNB); Saint-Louis (Montrouzier rec.) (coll. A. Fauvel in IRSNB) (Bielawski 1973).
description: Published as part of Nattier, Romain, Jourdan, Hervé, Mille, Christian & Chazeau, Jean, 2015, An annotated checklist of the Coccinellidae (Coleoptera) from New Caledonia, pp. 301-331 in Zootaxa 4058 (3) on pages 319-320, DOI: 10.11646/zootaxa.4058.3.1, http://zenodo.org/record/236980
Liolaemus pictus subsp. pictus
Creators: name: Pincheira-Donoso, Daniel
name: Scolaro, J. Alejandro
name: Sura, Piotr
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Liolaemidae
Liolaemus
Liolaemus pictus
Liolaemus pictus pictus (duméril & bibron)

description: Liolaemus pictus pictus (Duméril & Bibron)
Proctotretus pictus Duméril & Bibron 1837: 276 (type locality: “ Chile ”. Restricted to Valdivia, Los Lagos Region, Chile, Müller & Hellmich 1939); Bell 1843: 5; Guichenot 1848: 30.
Liolaemus (Liodera) pictus Fitzinger 1843: 74.
Liolaemus pictus Gray 1845: 213; Boulenger 1885a: 151; Pflaumer 1944: 113; Díaz & Lobo 2006: 264.
Chrysosaurus morio Guichenot 1848: 47 (sybonym fide Donoso-Barros 1966).
Eulaemus pictus Girard 1858a: 198.
Liolaemus (Eulaemus) pictus Girard 1858b: 364.
Proctotretus prasinus Cope 1868: 120 (synonym fide Boulenger 1885a).
Liolaemus pictus pictus Burt & Burt 1930: 17, 1931: 268, 1933: 36; Hellmich 1934: 135; Liebermann 1939: 70; DonosoBarros 1966a: 215, 1970a: 192, 1970b: 99; Webb & Greer 1969: 193; Cei 1986: 240; Vanzolini 1986: 16; Veloso & Navarro 1988: 510; Laurent 1992: 32; Núñez & Jaksic 1992: 75; Etheridge 1995: 33; Etheridge & Espinoza 2000: 8; Lobo 2001: 139; Scolaro 2006: 45.
Liolaemus morio Burt & Burt 1933: 34 (in part).
Liolaemus (Liolaemus) pictus pictus Pincheira-Donoso & Núñez 2005: 347.
description: Published as part of Pincheira-Donoso, Daniel, Scolaro, J. Alejandro & Sura, Piotr, 2008, A monographic catalogue on the systematics and phylogeny of the South American iguanian lizard family Liolaemidae (Squamata, Iguania), pp. 1-85 in Zootaxa 1800 on pages 29-30, DOI: 10.5281/zenodo.6789337
Hecamede abdominale
Creators: name: Sinclair, Bradley J.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Ephydridae
Hecamede
Hecamede abdominale

description: abdominale (Williston)
Hecamede abdominale Williston, 1896: 398.
Distribution. Introduced. Nearctic, Neotropical; Galápagos: Santa Cruz.
Material examined. Galápagos: Santa Cruz: Academy Bay, lagoon, 1 kmE CDRS, 18.xi.2001, B.J. Sinclair (7 ♁, 3 ♀, CNC).
Remarks. This is a widespread species in both inland and marine littoral zone environments (Mathis 1991).
description: Published as part of Sinclair, Bradley J., 2023, An annotated checklist of the Diptera of the Galápagos Archipelago (Ecuador), pp. 1-102 in Zootaxa 5283 (1) on pages 58-59, DOI: 10.11646/zootaxa.5283.1.1, http://zenodo.org/record/7912667
Athyroglossa tectora Cresson 1926
Creators: name: Sinclair, Bradley J.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Ephydridae
Athyroglossa
Athyroglossa tectora

description: tectora Cresson (W.N. Mathis pers. comm.).
Athyroglossa tectora Cresson, 1926: 249. Causton et al. 2006: 134 [introduced species].
Distribution. Introduced. Neotropical; Galápagos: Santa Cruz, Isabela.
Material examined. Galápagos: Isabela: Z. Agricola G. Gil, ex. pitfall trap #5, 4.xii.2002, A. Mieles, C. Garcia (1 ♀, CNC); Pto. Ayora Miraflores, -0.73866 -90.31676, 21.iii.2006, E. Lomas & D. Sabando (1 ♁, CNC).
Remarks. The first specimen was collected on Santa Cruz in November 2001 and several additional specimens were found later on Isabela.
description: Published as part of Sinclair, Bradley J., 2023, An annotated checklist of the Diptera of the Galápagos Archipelago (Ecuador), pp. 1-102 in Zootaxa 5283 (1) on page 59, DOI: 10.11646/zootaxa.5283.1.1, http://zenodo.org/record/7912667
Stethorini Dobzhansky 1924
Creators: name: Nattier, Romain
name: Jourdan, Hervé
name: Mille, Christian
name: Chazeau, Jean
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Coccinellidae

description: STETHORINI Dobzhansky, 1924
This whole tribe represents the only specialist mite (Tetranychidae) predators among the Coccinellidae (Biddinger et al. 2009). Recently, the two subgenera (Stethorus and Parastethorus) were elevated to the generic level (Slipinski 2007).
description: Published as part of Nattier, Romain, Jourdan, Hervé, Mille, Christian & Chazeau, Jean, 2015, An annotated checklist of the Coccinellidae (Coleoptera) from New Caledonia, pp. 301-331 in Zootaxa 4058 (3) on page 320, DOI: 10.11646/zootaxa.4058.3.1, http://zenodo.org/record/236980
Additional file 4: of Exercise and cancer-related fatigue in adults: a systematic review of previous systematic reviews with meta-analyses
Creators: name: Kelley, George
name: Kelley, Kristi
Publisher: name: Figshare
Year: 2017
Subjects: subject: Molecular Biology
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Post-treatment standardized mean difference (SMD) effect sizes for CRF from included meta-analyses. This file includes the overall post-treatment changes in CRF from included meta-analyses. (DOCX 57 kb)
Reflecting on the Use of Tabletop Exercises in the Classroom
Creators: name: McCracken-Joyce, Martin
Publisher: name: National Teaching Repository
Year: 2024
Subjects: classificationCode: 390303
subject: Higher education
classificationCode: 420505
subject: Nursing workforce

description: The School of Nursing: Impact & Innovation. A Compendium of Effective PracticeArticle Five: Reflecting on the Use of Tabletop Exercises in the Classroomby Martin McCracken-JoyceTabletop exercises are structured, discussion-based sessions that simulate emergency scenarios to encourage participants to engage in problem-solving and decision-making in a classroom setting. These exercises serve as a platform for participants to discuss their roles, responsibilities, and potential responses to emergencies under the guidance of a lecturer who directs the session through one or more pre-planned scenarios. The goal is to promote active participation, professional discourse, open-mindedness, and scenario commitment among students.Innovation & Impact: To access other articles in the Collection visit: https://doi.org/10.25416/NTR.c.7227298Compendium: DOI: 10.25416/NTR.25795573
Reflecting on the Use of Tabletop Exercises in the Classroom
Creators: name: McCracken-Joyce, Martin
Publisher: name: National Teaching Repository
Year: 2024
Subjects: classificationCode: 390303
subject: Higher education
classificationCode: 420505
subject: Nursing workforce

description: The School of Nursing: Impact & Innovation. A Compendium of Effective Practice

Article Five: Reflecting on the Use of Tabletop Exercises in the Classroom

Martin McCracken-Joyce

Tabletop exercises are structured, discussion-based sessions that simulate emergency scenarios to encourage participants to engage in problem-solving and decision-making in a classroom setting. These exercises serve as a platform for participants to discuss their roles, responsibilities, and potential responses to emergencies under the guidance of a lecturer who directs the session through one or more pre-planned scenarios. The goal is to promote active participation, professional discourse, open-mindedness, and scenario commitment among students.

Innovation & Impact: To access other articles in the Collection visit: https://doi.org/10.25416/NTR.c.7227298

Compendium: DOI: 10.25416/NTR.25795573