cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Ενδείξεις για πρόκληση σεισμικότητας λόγω μεταβολών των τάσεων Coulomb με ανάλυση του πεδίου των τάσεων
Creators: name: Αναγνώστου, Βασίλειος Κωνσταντίνου
Publisher: name: Aristotle University of Thessaloniki
Year: 2023
Subjects: Αντιστροφή πεδίου τάσεων
Μεταβολές τάσης Coulomb
Πρόκληση σεισμικότητας
Stress inversion
Coulomb stress transfer
Stress triggering

description: Η παρούσα πτυχιακή εργασία έχει ως θέμα τη διερεύνηση της ευαισθησίας στην πρόκληση σεισμικότητας λόγω της σεισμικής ολίσθησης ισχυρών σεισμών από τις ιδιότητες του πεδίου των τάσεων σε στοχευμένες περιοχές του κεντρικού Ιονίου. Στο πρώτο κεφάλαιο περιγράφεται το σεισμοτεκτονικό καθεστώς της περιοχής μελέτης και δίνονται στοιχεία για την ιστορική και ενόργανη σεισμικότητα της περιοχής. Στο δεύτερο κεφάλαιο περιγράφεται η μεθοδολογία που ακολουθήθηκε για την αντιστροφή του πεδίου των τάσεων και για τον υπολογισμό των μεταβολών τάσεων Coulomb. Στο τρίτο κεφάλαιο παρουσιάζονται τα αποτελέσματα των αντιστροφών καθώς και τα αποτελέσματα από τους υπολογισμούς των μεταβολών τάσεων Coulomb με ταυτόχρονη διερεύνηση για την πρόκληση σεισμικότητας σε κάθε μια από τις υποπεριοχές της περιοχής μελέτης. Τέλος, στο τέταρτο κεφάλαιο, καταγράφονται τα συμπεράσματα της παρούσας εργασίας για τις αντιστροφές του πεδίου των τάσεων της περιοχής καθώς και οι ενδείξεις για πρόκληση σεισμικότητας εξαιτίας των μεταβολών των τάσεων Coulomb.
description: The aim of the present thesis was the investigation of the stress triggering sensitivity due to the seismic slip of strong earthquakes by detailing the stress pattern in targeted areas of the central Ionian. In the first chapter, the seismotectonic regime of the study area is described and information is given on the historical and instrumental seismicity of the area. The second chapter describes the basic principles of the methodology used for the stress inversions and the Coulomb stress change calculations. In the third chapter, the results of the inversions are presented as well as the results from the calculations of the Coulomb stress changes with a simultaneous investigation for the stress triggering in each of the sub-regions of the study area. In the final chapter, the conclusions of this thesis are recorded on the stress inversions in the area as well as the evidence of stress triggering due to Coulomb stress transfer.
CCWI2017: F34 'An integrated state estimation approach to enhance the on-line monitoring capabilities of water distribution systems'
Creators: name: Díaz, Sarai
name: González, Javier
name: Mínguez, Roberto
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: State estimation techniques have been widely discussed in academia in the context of water distribution systems, but there are few real-life applications. The aim of this paper is to show the potential advantages of systematically implementing state estimation techniques for on-line monitoring water distribution systems. With this purpose, two state estimation-based methodologies are here applied to C-Town case study: (1) calibration via multi-period state estimation, in order to adjust model parameters based on state estimation results over time, and (2) topological state estimation, in order to identify changes in the statuses of pumps and valves. Results show that state estimation techniques are a good alternative to adapt the paradigm of water distribution networks analysis to the reality of telemetry systems.
Geröllfeld
Creators: name: Schwander, Markus
Publisher: name: Palette
Year: 2019
Subjects: subject: Bergsturz
subject: Collage
subject: Skulptur
subject: Situation
subject: site specific
subject: Bondo
subject: Plurs
subject: 700 - Künste, Bildende Kunst allgemein
subject: 730 - Plastik, Numismatik, Keramik, Metallkunst

description: Die Ausstellung von Markus Schwander umfasst drei mehrteilige Arbeiten. Ausgangspunkt für die neu entstandenen Werke im Kontext des Palazzo Salis sind topografische und kulturhistorische Impressionen und Geschichten. Diese hat der Künstler bei seinen Recherchen im Val Bregaglia gesammelt und fotografisch festgehalten. Markus Schwanders Schaffen zeugt vom Weiterdenken und Verarbeiten vorgefundener Gegenstände und deren Prägung. Als Abgüsse und Modelle bilden seine Skulpturen Dinge ab, frieren Bewegungen ein und verzahnen Gegenstände zu Assemblagen. Auf diesem Prinzip von Selektion und Addition basieren auch seine Collagen.
title: Data Stewardship Maturity Report for GHRSST Level 2P North Atlantic Regional Bulk Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the NOAA-18 satellite (GDS version 1)
Creators: name: Lemieux, Paul
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00228
Of Metabolic Myth
Creators: name: Allen, Jamie
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2022
Subjects: subject: media
subject: food
subject: film
subject: fake
subject: 700 - Künste und Unterhaltung

description: There are few areas of material culture from which people demand more authenticity, integrity and transparency than the techniques and materialities surrounding food. Foods materialise myths and imaginaries of nature and modernity, and entire regional economies and national cuisines rely on evolved and invented stories about where and how foodstuffs are prepared. At the same time, systems of provenance are challenging to establish, fakes common, and forgery rampant. Cultures and peoples the world over concern themselves with the genuineness of dishes and the pedigree of raw materials and preparations. Governance and policy structures attempt to snare those who wilfully or otherwise commit the deep offence of violating the economic sanctity or highly intimate significance of foods. Food processes are faked, adulterated, contaminated and stigmatised in ways that deeply revolt, pervert and reveal those things about which human beings care most deeply. The myths, materiality, media, systems and infrastructures of food are a metabolic imaginary that links seemingly simple alimentary processes to notions of truth-telling and authenticity. Our culinary techniques and performances of socialisation, story- telling and identity show, yet again, that “truth is a matter of the imagination”.
CCWI2017: F95 'A REAL TIME SYSTEM FOR DETECTING EVENTS IN WATER NETWORKS'
Creators: name: Meeus, Shana
name: Dene Marshallsay
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: Water distribution networks will need to evolve to meet the future challenges of population growth, climate change, aging infrastructure and ever increasing customer expectations. Part of this evolution will be the use of smarter systems to manage the network based on advanced data analytics. This paper presents a new system for automatically detecting abnormal events that occur in water networks and automatically reporting alarms back to the operators. The system makes use of existing flow data, without the need for new hardware or changes to the logging frequency of flow data. The paper presents the development of the system and examples from a case study with Dŵr Cymru Welsh Water.
Metabolomics Data. Disruption of glucagon receptor signaling causes hyperaminoacidemia exposing a possible liver - alpha-cell axis.
Creators: name: Galsgaard, Katrine
Publisher: name: figshare
Year: 2017
Subjects: subject: 60101 Analytical Biochemistry
subject: FOS: Biological sciences
subject: 60603 Animal Physiology - Systems

description: Suplementary data to the article: Disruption of glucagon receptor signaling causes hyperaminoacidemia exposing a possible liver - alpha-cell axis
CCWI2017: F116 'Extracting Temporal Patterns for Contamination Event Detection in a Large Water Distribution System'
Creators: name: Cheifetz, Nicolas
name: Kraiem, Selma
name: Mandel, Pierre
name: Féliers, Cédric
name: Heim, Véronique
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: Monitoring water quality in a drinking Water Distribution Network (WDN) is typically based on several sensors that are deployed on different locations of the WDN. Each sensor measures one or multiple signals, and the real challenge resides in detecting significant contaminations by analyzing these water quality signals. In practice, some detection methods may fail due to a specific design to certain forms of contaminants as well as a generic formulation with model-free algorithms. Both cases might trigger false alarms or produce no detection when a contamination occurs. Moreover the problem is hardly addressed when the underlying hydraulic regime changes over time causing fluctuations in the detection statistics. Such variation can dramatically decrease the detection performance or result to misleading analysis. Events like source shifting or tank filling are normal situations and can occur frequently depending on the operating conditions. This paper aims to deal with the variability of the contamination events under various operational conditions in water networks. The procedure is fully data-driven and leads to the extraction of meaningful temporal patterns using various data analysis techniques. This methodology can be used as a preprocessing stage to improve the performance of any algorithm to detect contaminations. The proposed approach is illustrated on a large real-world network in France and a qualitative interpretation is given to highlight a better understanding of the hydraulic regimes over time.
Synergistic immuno-chemotherapy in ovarian cancer
Creators: name: Wahba, John
Publisher: name: Imperial College London
Year: 2018

description: Epithelial ovarian cancer (EOC) is the most lethal of all gynaecological malignancies due to its non-specific signs and symptoms, lack of a reliable screening tool and development of treatment resistant cancer. Cancers have developed strategies to evade immune recognition including the programmed death (PD) pathway. Tumour cells express the ligand PD-L1 which binds to its receptor, PD-1 on T cells, dampening T cell effector function and leading to immunosuppression. Immunotherapy aims to re-address the status quo by breaking peripheral immunosuppression, and this has great potential in immunogenic cancers like ovarian cancer. The aim of this project was to explore the relationship between conventional chemotherapy and novel adoptive immunotherapeutic strategies such as the chimeric antigen receptor (CAR) T cells (T4 cells) for ovarian cancer and whether this effect could be enhanced with PD-1 receptor blockade. We were able to demonstrate the effective application of combination treatment in in vitro and in vivo models of EOC. Both paclitaxel and carboplatin synergised with ErbB-targeted T4 cells, significantly reducing tumour burden, with further enhancement following PD-1 receptor blockade by nivolumab. This most likely occurs by counteracting the increased up-regulation of PD-L1 on tumour cells which was observed following treatment of tumour cells with chemotherapy. We identified mechanisms which significantly contribute to this synergy such as the effect of chemotherapy on the tumour cell cycle dynamics, apoptosis machinery and autophagy. The mechanism of synergy is multifaceted and multifactorial, and is likely to involve other pathways which still remain to be investigated. Targeting these pathways may prove beneficial in order to maximise the benefit from chemo-immunotherapy. Our work demonstrates a therapeutic advantage of chemo-immunotherapy in the treatment of ovarian cancer by targeting cancer’s immunosuppressive nature and breaking peripheral tolerance mechanisms.
title: Data Stewardship Maturity Report for GHRSST Level 2P North Atlantic Regional Bulk Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the NOAA-16 satellite (GDS version 1)
Creators: name: Lemieux, Paul
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00231
An investigation into crosstalk between cohesion and the Smc5/6 complex during the cell cycle
Creators: name: Mykura, Charlotte
Publisher: name: Imperial College London
Year: 2017

description: Elaborate mechanisms have evolved which allow cells to faithfully segregate their DNA into two daughters during each cell cycle. Such mechanisms ensure that DNA is stably inherited over generations, and also is a dynamic, functional entity in the context of the cell cycle. A set of protein complexes which are key players in governing chromatin architecture during the cell cycle are the Structural Maintenance of Chromosomes (SMC) complexes; cohesin, the Smc5/6 complex and condensin. Cohesin is essential for sister chromatids to remain associated from their synthesis in S-phase right up until they are separated during mitosis. This cohesion is thought to be mediated by the ability of cohesin to physically embrace DNA strands within its ring-like structure. For cohesin to form cohesive links between sister chromatids, it must first be acetylated by the Eco1 acetyl transferase, and following cohesion generation in S-phase, Eco1 is degraded. During mitosis, it is essential that cohesion be removed to prevent aberrant mitoses. Cohesin maintains sister chromatid identity, but also facilitates homologous recombination should DNA damage occur. Our knowledge of the Smc5/6 complex thus far heavily implicates it in DNA damage repair. However, growing evidence suggests that the Smc5/6 complex and cohesion dynamics could be mechanistically linked. This investigation submits evidence exploring the hypothesis that the Smc5/6 complex may be regulating cohesion during an unperturbed cell cycle. A study of a putative interaction between Smc5/6 and Mck1 leads us to propose that the Smc5/6 complex has a role, directly or indirectly in Eco1 turnover. Further, evidence presented suggests that the Smc5/6 complex may have a role in regulating cohesin acetylation by Eco1. This investigation also involves the study of an Eco1 putative SUMO interacting motif.
Nudging in der Gesundheitsförderung - Den Weg für gesunde Entscheidungen bereiten
Creators: name: Ott, Ida Cathrina
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2022
Subjects: subject: 610 - Medizin und Gesundheit

description: Nudges, also kleine Anstupser, sollen uns Menschen helfen, im Alltag «gute» und «gesunde» Entscheidungen zu treffen. Mehr Entscheidungen für gesundheitsförderliches Verhalten könnten sowohl Menschen zu mehr Wohlbefinden verhelfen wie auch Gesundheits- und Sozialsysteme finanziell entlasten. Der Vortrag setzt sich deshalb mit der Frage auseinander, wie Nudging in den Kontext der Gesundheitsförderung und Prävention (GFP) übertragen werden kann. Dazu wird der theoretische Hintergrund des Nudgings beleuchtet. Es folgt eine Diskussion der Legitimation und der bisherigen Erkenntnisse zur Wirksamkeit von Nudging im Kontext der GFP. Der zweite Teil veranschaulicht, anhand welcher Methoden Anwender*innen in der GFP selbst Nudges entwickeln und sinnvoll einsetzen können. Dabei erhalten die Teilnehmenden Einblick in Praxisbeispiele und werden zum Transfer in die eigene Arbeit angeregt.
Ο ρόλος των πατριαρχών και της συνόδου κατά τις δυναστικές διαμάχες επί Παλαιολόγων (14ος αιώνας). Συμβιβαστικές προσπάθειες και υποστήριξη της νομιμότητας
Creators: name: Αποστόλου, Στυλιανός Ευαγγέλου
Publisher: name: Aristotle University of Thessaloniki
Year: 2023
Subjects: Πατριάρχες και σύνοδος
Δυναστικές διαμάχες στο Βυζάντιο επί Παλαιολόγων
14ος αιώνας
Patriarchs and synod
Dynastic disputes in Byzantium during the Palaiologian period
14th century

description: Σκοπός της παρούσας μεταπτυχιακής εργασίας είναι να σκιαγραφήσει τον ρόλο που διαδραμάτισαν οι πατριάρχες και η πατριαρχική σύνοδος κατά τις δυναστικές έριδες που εκδηλώθηκαν στα χρόνια των Παλαιολόγων τον 14ο αιώνα, προκειμένου να τηρηθεί η νομιμότητα και να διασφαλιστεί η πολιτική σταθερότητα στο κράτος. Μέσα από την εξέταση του θέματος φωτίζονται οι σχέσεις Κράτους και Εκκλησίας στο Βυζάντιο με έμφαση στον 14ο αιώνα, όταν η Εκκλησία διαδραμάτιζε σημαντικότατο ρόλο στην υποστήριξη της αυτοκρατορικής εξουσίας. Για τις ανάγκες της έρευνας αξιοποιήθηκαν οι αφηγηματικές πηγές της εποχής, όπως το ιστορικό έργο του Ιωάννη ΣΤ΄ Καντακουζηνού και του Νικηφόρου Γρηγορά. Παράλληλα, μελετήθηκαν τα πατριαρχικά και συνοδικά έγγραφα της περιόδου που μαρτυρούν ενέργειες στις οποίες προέβη ο πατριάρχης ή/και η σύνοδος σε συνεργασία ή με παρότρυνση του αυτοκράτορα για προσέγγιση της αντίπαλης πλευράς. Συγχρόνως, μελετήθηκε κριτικά και αξιοποιήθηκε η σχετική δευτερεύουσα βιβλιογραφία για τους εμφύλιους πολέμους, τη θέση της Εκκλησίας στο Βυζάντιο τον 14ο αιώνα και τις σχέσεις της με την αυτοκρατορική εξουσία.
description: The aim of this thesis is to outline the role played by the patriarchs and the patriarchal synod during the dynastic disputes that occurred during the Palaiologan period in the 14th century, in order to support legitimacy and ensure political stability in the state. Through the examination of this topic, the relations between the State and the Church in Byzantium are highlighted, with emphasis on the 14th century, when the Church played a major role in supporting imperial power. For the purposes of the research, the narrative sources of the period, such as the historical works of Ioannes VI Kantakouzenos and Nikephoros Gregoras, were thoroughly examined. Furthermore, the patriarchal and synodal documents of the period were studied, as they demonstrate the actions taken by the patriarch and/or the synod in collaboration with or at the urging of the emperor in order to approach the opponent’s side. At the same time, the relevant secondary bibliography on the civil wars, the position of the Church in Byzantium in the 14th century and its relations with the imperial power were critically studied and consulted.
title: Data Stewardship Maturity Report for GHRSST Level 2P Global Bulk Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the NOAA-17 satellite produced by NAVO (GDS version 1)
Creators: name: Lemieux, Paul
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00235
CCWI2017: F38 'Real-time Whole-cost Optimization of Water Production and Distribution'
Creators: name: Sunela, Markus I.
name: Puust, Raido
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: Optimizing water production and distribution in near real-time can result in significant savings in energy and chemical costs. This paper presents a novel, generic optimization framework, based on a single-solution meta-heuristic optimization algorithm called modified hybrid discrete dynamically dimensioned search (MHD-DDS). The optimization framework finds optimal settings for all stations in the network and optimal frequencies for all variable-speed driven pumps (VSP) for the 24 hours following the optimization run start. Tampere water supply system was used as a large-scale case- study, and the optimization was able to reduce production and distribution costs by almost 20 % while ensuring better quality of service (QoS) than before.
title: Data Stewardship Maturity Report for GHRSST Level 2P Global 1m Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the NOAA-19 satellite produced by NAVO (GDS versions 1 and 2)
Creators: name: Lemieux, Paul
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00237
Overcoming barriers to joint preserving surgery in gonarthrosis
Creators: name: Jones, Gareth Griffith
Publisher: name: Imperial College London
Year: 2017

description: Total knee replacement (TKA) accounts for 90% of knee replacement procedures performed in the UK for gonarthrosis (knee osteoarthrosis), despite one in five patients being dissatisfied with the outcome. Unicondylar knee replacement (UKA) and high tibial osteotomy (HTO) are alternative joint preserving procedures, but infrequently used. This thesis explores perceived barriers to their wider adoption, and how technology might help overcome these barriers. Addressing the lack of objective evidence comparing joint preserving procedures with TKA, a commercially available treadmill was used in conjunction with a novel machine learning approach to gait analysis. The results indicate that UKA produces a more ‘normal’ gait. Many surgeons are discouraged by the high rate of complications associated with HTO surgery. CAD software was used to understand better the procedure in three dimensions: a biplanar rather than a uniplanar medial opening wedge osteotomy was found to have small but significant geometrical advantages for bony union; accurate hinge axis positioning prevents alterations in tibial slope; and routine measurement of average hinge width may reduce the incidence of fractures. HTO and UKA are technically challenging, with higher revision rates than TKA when performed by non-expert surgeons. Indeed, two saw-bone experiments confirmed that inexperienced surgeons were significantly less accurate than experts using conventional instruments for HTO and UKA, but could be instantly upskilled to the level of expert surgeons by using a novel 3D printed patient specific instrument (PSI). Tested in vivo by expert surgeons, the same PSI guides for UKA and HTO reproduced the pre-operative plan to within 3° in the sagittal and coronal planes, although accuracy of the HTO guide diminished with larger angular corrections. Future work will aim to establish whether PSI can upskill non-expert surgeons in vivo, and ascertain the correlation between improved accuracy, the 3D operative plan, and patient outcomes.
Additional file 1: of Secondary-Transferring Graphene Electrode for Stable FOLED
Creators: name: Teng, Yunjie
name: Tong, Shoufeng
name: Zhang, Min
Publisher: name: figshare
Year: 2018
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Figure S1. The count of Ig’/Ig as shown in the following figure. Most of the Ig’/Ig values are concentrated at 1.75 and the standard deviation was 0.015, which shows the consistency of the sample quality, while somewhere the Ig’/Ig was ~ 0.8, which illustrates bilayer of graphene sample and the monolayer rate of our graphene sample is > 90%. (DOCX 106 kb)
Das französische Cembalo im 17. Jahrhundert und seine Verwendung
Creators: name: Grobelnik, Thys
Publisher: name: Hochschule für Musik Basel FHNW, Schola Cantorum Basiliensis
Year: 2022
Subjects: subject: 780 - Musik

description: In der ersten Hälfte des 17. Jahrhunderts bilden sich in Frankreich 2 Cembalobau-Traditionen. Diese koexistieren bis zum Anfang des 18. Jahrhunderts. Sie unterscheiden sich sowohl in der Konstruktion wie im Klang und wurden jeweils für verschiedene Aufgabenbereiche eingesetzt. Vorgestellt werden einige Vorzeigeinstrumente der beiden Traditionen und deren Eigenschaften erklärt. Durch schriftliche und ikonographische Quellen sehen wir, dass der französische Geschmack sehr fein und delikat war. Die Ästhetik von Orgeln und Cembali war sehr ähnlich. Ebenso wird die Problematik der Terminologie der Wörter Clavecin und Espinette besprochen und erläutert.
CCWI2017: F25 'Unsteady flow modelling of RTC in water distribution networks'
Creators: name: Creaco, E.
name: Campisano, A.
name: Franchini, M.
name: Modica, C.
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: This paper describes the use of the unsteady flow modelling (UFM) for the simulation of remote Real Time Control (RTC) of pressure in water distribution networks (WDNs). The developed model combines UFM with specific simulation modules for generation of pulsed nodal demands and dynamic adjustment of pressure control valves. The results of the application to a skeletonized WDN show that UFM provides a sound description of the amplitude of the pressure head variations at the controlled node. Further calculations prove the RTC algorithm to be stable in the presence of measurement errors on the monitored variables.
Attitudes about when and how to treat patients with AL amyloidosis: an international survey
Creators: name: Milani, Paolo
name: Morie A. Gertz
name: Merlini, Giampaolo
name: Dispenzieri, Angela
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The aim of this survey was to describe the treatment decision making of expert physicians in when and how to treat patients with AL amyloidosis. Fifty amyloid expert physicians completed the survey. Autologous stem cell transplant (ASCT) was considered the first line therapy, if medically feasible, by 73% of the physicians. Excluding ASCT, cyclophosphamide-bortezomib-dexamethasone regimen was the preferred strategy by 72%. Depending on organ involvement, the goal for treatment was CR for 27–35% and very good partial response (VGPR) for 65–72%. In the absence of organ progression but rising FLC, the factors that most influenced when to reinstitute therapy included: dFLC at diagnosis (35.2%); how sick the patient was at diagnosis (24.1%); and time to FLC rise (18.5%). For patients who achieved CR after first-line, in the presence of cardiac/renal progression, 37/42% of providers would consider starting clone directed therapy without evidence of a clone. These data would imply that the current definitions of hematologic progression do not match clinical judgment, clinical experience and a comprehensive evaluation of patient status. These disparities challenge the ability to design therapeutic trials for patients with relapsed/refractory disease. A consensus statement with the definition and validation of new hematologic progression criteria is required.
title: Data Stewardship Maturity Report for GHRSST Level 2P Global 1m Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the NOAA-18 satellite produced by NAVO (GDS versions 1 and 2)
Creators: name: Lemieux, Paul
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00236
title: Data Stewardship Maturity Report for GHRSST Level 2P Global 1m Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the MetOp-B satellite produced by NAVO (GDS version 2)
Creators: name: Lemieux, Paul
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00230
title: Data Stewardship Maturity Report for GHRSST Level 2P Global 1m Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the MetOp-A satellite produced by NAVO (GDS versions 1 and 2)
Creators: name: Lemieux, Paul
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00240
Environmental influences on Fusarium head blight
Creators: name: Halder, Julia Basak
Publisher: name: Imperial College London
Year: 2017

description: Fusarium Head Blight (FHB), a devastating disease of cereal crops worldwide, is receiving much attention to all facets of its biology. Given that a major challenge for agriculture is the changes driven by climate change, this thesis explored the effect of environmental conditions on three aspects of the biology of the causal fungi. At the within-season level, data on contamination of crops by FHB toxins were used to create a statistical model linking weather to toxin level, which closely follows the weather stated in guidance to farmers as increasing risk and performs similarly to other weather-only models for FHB. The model was used in conjunction with downscaled climate model output driven by a high emissions scenario to assess whether changes in risk due to changing weather are projected. Those projections do not suggest a large change in risk if the relationship with weather remains constant, but caveats for the projections are explained within. At the global level, published data on the distribution of two key Fusarium fungi were examined. The data were linked with agroecological data and statistical models built to test hypotheses on the influence of the presence of rice, maize, and climate factors on the relative prevalences of the species. The models support the hypotheses that rice presence increases the prevalence of F. asiaticum, while maize increases the presence of F. graminearum. The models add to the literature on fungal species distributions utilizing generalized linear mixed models. Finally, a large collection of isolates was studied with respect to growth at different temperatures to ascertain within- and between-population variation in this phenotype. The work was incomplete and inconclusive; results suggest little definitive relationship with examined variables but the protocols and further work suggested could be carried out on other fungal populations and then incorporated with genetic data to assess the potential for survival and evolution under environmental change.
Spatial and temporal distribution of Onchocerciasis in West Africa with particular reference to Ghana
Creators: name: O'Hanlon, Simon
Publisher: name: Imperial College London
Year: 2016

description: Background. Quantifying and predicting the effect of control interventions against infectious diseases requires knowledge about prevalence prior to the implementation of such control measures as well as knowledge of key parameters which affect model outcomes. Here is presented the first geostatistical map estimating the prevalence of human onchocerciasis in the former Onchocerciasis Control Programme in West Africa (OCP) before the initiation of vector control operations in 1975. The map is used to quantify the burden of onchocercal skin disease prior to interventions. The results of a socioeconomic survey investigating coverage and compliance to community-directed treatment with ivermectin are then presented. Methods and Findings. The OCP epidemiological database was investigated for spatial autocorrelation. A total of 737 village surveys had parasitological examinations conducted prior to the start of control. Using these 737 pre-control data points plus environmental covariates, a Bayesian model-based geostatistical (B-MBG) approach was used to generate a continuous surface (at a pixel resolution of 25km2) of microfilarial prevalence in West Africa prior to the commencement of the OCP. The mean Pearson’s correlation between observed prevalence and model-estimates of prevalence at hold-out locations was 0.693; mean prediction error was 0.77% and mean absolute prediction error was 12.2%. Within OCP boundaries, 17.8 million people were deemed to be at risk and 7.6 million infected in 1975 which is greater than previous estimates. The mean microfilarial prevalence across all countries was 45% (range: 2–90%). Conclusions and Significance. This is the first map of continuous onchocerciasis prevalence in West Africa, developed using robust geostatistical methods. Important environmental predictors of infection prevalence were identified and used in a model that out-performs those without spatial-random effects or environmental covariates. Our results may be compared with recent epidemiological mapping efforts to find areas of persisting transmission, informing feasibility of elimination with current and novel tools.
Virtuelle Kooperation im OE-Forum Schweiz: Einflussfaktoren auf die Einstellung zur Nutzung der digitalen Kooperationsplattform Trello im OE-Forum Schweiz
Creators: name: Müller, Nicole
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2016

description: Die vorliegende Thesis untersucht die Fragestellung, welche Faktoren die Einstellung zur Nutzung einer digitalen Kooperationsplattform im Beraternetzwerk OE-Forum Schweiz beeinflussen. Dafür wurde das Technologieakzeptanzmodell im Kontext einer virtuellen Kooperation im Beraternetzwerk angewandt. In einer Fragebogenuntersuchung wurden die Faktoren soziale Norm, wahrgenommene einfache Bedienbarkeit, wahrgenommener Nutzen, Einstellungs- und Verhaltensakzeptanz überprüft. Zusätzlich wurden Interviews zur Beantwortung der Frage geführt, ob grundsätzlich ein Interesse an einer kooperativen Tagungsorganisation besteht. Die Ergebnisse bestätigen die Vorhersage des Modells, der wahrgenommene Nutzen sei stärkster Prädiktor der Einstellungsakzeptanz. Der Einfluss der wahrgenommenen einfachen Bedienbarkeit und der Erfahrung mit technologischen Systemen konnten nicht nachgewiesen werden. Die Anwendung des Technologieakzeptanzmodells in einem Beraternetzwerk wird anhand der vorliegenden Untersuchung nur mit Anpassungen empfohlen. Die Implementierung der digitalen Plattform im OE-Forum Schweiz wird als gelungen bewertet. Wobei bezüglich deren Einsatz noch Optimierungspotential besteht.
title: Data Stewardship Maturity Report for GHRSST Level 2P Atlantic Regional Bulk Sea Surface Temperature from the Advanced Very High Resolution Radiometer (AVHRR) on the NOAA-17 satellite (GDS version 1)
Creators: name: Lemieux, Paul
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00238
title: Estimation of Bycatch with Seabirds, Sea Turtles, Bony Fish, Sharks, and Rays in the 2020 Permitted American Samoa Longline Fishery
Creators: name: McCracken, Marti
Publisher: name: Pacific Islands Fisheries Science Center (U.S.)
Year: 2022

description: PIFSC data report; DR-22-001
Überforderung als Luxusproblem
Creators: name: Giudici, Anja
name: Grizelj, Sandra
Publisher: name: Neue Zürcher Zeitung
Year: 2017
Subjects: subject: Fremdsprachenunterricht
subject: Mehrsprachigkeit
subject: Schweiz
subject: Historische Bildungsforschung
subject: 370 - Erziehung, Schul- und Bildungswesen
subject: 940 - Geschichte Europas

description: In den Deutschschweizer Kantonen wird immer wieder über den Fremdsprachenunterricht in der Schule abgestimmt. Im Tessin und in der Westschweiz kommt es nicht zu solchen Urnengängen. Wichtiger Grund dafür ist das Verhältnis der Mehrheitssprache Deutsch zu den Minderheitensprachen: Die deutschsprachige Schweiz kann es sich leisten, eine Überforderungsdebatte zu führen, die anderen Sprachregionen weniger, weil sie eine Minderheit sind.
CCWI2017: F103 'Self-Tuning Pump Operation Mode For Fluid Storages To Increase Energy Efficiency'
Creators: name: Hieninger, Thomas
name: Schmidt-Vollus, Ronald
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: This contribution deals with a self-tuning strategy for centrifugal pumps running fluid storages to decrease energy demand. The results are based on a MATLAB/Simulink model of a pump system, which is explained and verified. To analyse the energy demand and time for filling processes and to examine the applicability of the self-tuning strategy three possible systems and different filling strategies are regarded. Based on the most efficient strategy a self-tuning program was developed. For this program, convenient starting conditions and target values for constant or variable outflow are described. Thus, this optimisation strategy can be used as an on-line tuning program, which is simple to implement in running pump storage systems. The tuning strategy is tested with a genetic algorithm and a Nelder-Mead algorithm. Finally, a self-tuning program for fixed time operation mode is shown.
Visualizing climate science: the poster between science and politics
Creators: name: Brönnimann, Stefan
name: Allen, Jamie
name: Sobecka, Karolina
name: Suess, Solveig
name: Chatterjee, Sira
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2020
Subjects: subject: 700 - Künste und Unterhaltung

description: The geosciences play a role outside of the natural, research sciences as agents responding to geopolitical crises like climate change and corporate and military interests that seek strategic advantage in planetary repair and control. The notion of the neutrality of science has increasingly eroded with researchers more frequently becoming embroiled in public deliberation and policy. Geoscientists are being asked to project the future of physical earth systems as well as evaluate the performance of policies (Beck and Mahony 2018) contributing to solutions and providing metrics for “climate services” (Daly and Dilling 2019). How the story of the earth, its climate and ecology, are told, is developed in specific ways, evoking different kinds of value and purpose for different communities.
Use of mesenchymal stem cells for preconditioning of kidney grafts in an ex-vivo kidney perfusion model
Creators: name: Vallant, Natalie
Publisher: name: Imperial College London
Year: 2018

description: Introduction: One of the biggest issues in transplantation today is the lack of suitable transplantable organs for an increasing number of patients on the transplant waiting lists. Efforts to address this problem are made by the including organs from extended-criteria and donation-after-cardiac death donors, however these organs show inferior outcomes. Advances in organ preservation are needed to focus on techniques to assess and optimise organ viability prior to transplantation. Methods: This research focuses on organ preconditioning using hypothermic- and normothermic ex-vivo machine perfusion technology in combination with stem cell treatment. A transplational approach ranging from small animal models via porcine to human models was used with an intent to facilitate translation of findings into clinical practice. A portable rapid sampling micro-dialysis (rsMD) device was tested which might enable live monitoring of kidney grafts during preconditioning periods and help estimate the condition of organs. Results: In the first head to head comparison between hypothermic and normothermic machine perfusion for organ preconditioning ex-vivo, an advantage for hypothermic perfusion was detected in the porcine model. Contrary to this, in the transplational model using human organs, the outcome was dependent on demographic backgrounds of the organs; especially the cold ischemia time organs were exposed to had an impact on which perfusion modality was better for an organ. RsMD can successfully provide detailed real-time information on tissue and organ viability at all timepoints of organ preservation. Delivery of Mesenchymal Stem Cells (MSC) into grafts ex-vivo by machine perfusion was possible for the hypothermic- as well as the normothermic setting. MSCs could be traced within the grafts, but did not immediately alter their function. Conditioned Mesenchymal Stem Cell media can influence the phenotype of immune cells, e.g. macrophages. Dependent on the genetic background of MSCs, the obtained conditioned media showed to influence macrophages in different ways. Conclusion: This research has been successful in its overall objective to introduce Mesenchymal Stem Cells into ex-vivo machine perfusion settings. By doing so the goal would be to alleviate ischemia reperfusion injury of organs for transplantation and to thereby expand the pool of acceptable donor organs.
Pollution topologies. Can extinction have measure?
Creators: name: Savic, Selena
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2022
Subjects: Pollution
Measurement
Microchips
Insects
Taxonomy
Extinction
Artwork

description: This text is a parable on extinction and pollution and how they can be measured. In Inanimate Species, Joana Moll expresses extinction and pollution[1] quite literally in terms of analogy: the encroachment of microchips is compared to the extinction of insects. The comparison between these two visually similar[2] groups of beings is a measure of artificiality of pollution, as well as of inherent inconsistencies in methods of measurement. The attempt to taxonomize microchips following the rules of taxonomy for living organisms – an already artificial method applied to nature – suggests a possible way of forging an agreement on shared measures and values.
The vaginal microbiome in preterm prelabour rupture of the fetal membranes
Creators: name: Brown, Richard
Publisher: name: Imperial College London
Year: 2018

description: Preterm prelabour rupture of the fetal membranes (PPROM) and premature cervical dilatation are driven by bacterial-induced inflammation, often resulting in late miscarriage, preterm birth, chorioamnionitis and early onset neonatal sepsis (EONS). The vaginal microbiome is considered a key determinant of pregnancy outcome but relatively little is known about its composition in these adverse pregnancy events. PPROM is treated with erythromycin, whilst the management of premature cervical dilatation is contentious, including expectant management with bed-rest or emergency cervical cerclage. This thesis aimed to; 1) prospectively profile vaginal bacterial composition using next generation sequencing prior to and following PPROM and emergency cerclage, 2) examine the impact of erythromycin on vaginal bacterial composition, 3) investigate the anti-inflammatory properties of erythromycin in vaginal epithelial cells (VEC) and amniocytes and 4) retrospectively analyse the success of emergency cerclage. Vaginal bacterial communities deficient in Lactobacillus spp. were observed prior to PPROM in a quarter of cases and 40% of women presenting with premature cervical dilatation. Erythromycin treatment exacerbated Lactobacillus spp. depletion creating vaginal communities enriched with pathobionts associated with subsequent funisitis and EONS and did not inhibit inflammation in VECs or amniocytes in-vitro. Emergency cerclage was successful in 66% of cases. Cervical dilatation > 2cm, CRP >10mg/dL, the presence of G. vaginalis and maternal symptoms were all associated with poor outcomes. The data presented in this thesis demonstrate that reduced Lactobacillus spp. abundance is a risk factor for subsequent PPROM, premature cervical dilatation, chorioamnionitis and EONS. Modification of Lactobacillus spp. deplete communities in early pregnancy and alternative treatment strategies following PPROM may improve pregnancy outcomes. Emergency cervical cerclage is a successful procedure in the majority of cases and should be considered as first line treatment for premature cervical dilatation, especially in women with minimal cervical dilatation, low CRP and an absence of G. vaginalis.
CCWI2017: F68 'Mechanical reliability analysis of a real network to support the design of Isolation Valve System'
Creators: name: Berardi, Luigi
name: Laucelli, Daniele B.
name: Simone, Antonietta
name: Raspati, Gema
name: Ugarelli, Rita Maria
name: Giustolisi, Orazio
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: The Isolation Valve System (IVS) allows to detach some portions of water distribution networks (WDN) to perform planned (e.g. maintenance) or unplanned (e.g. failures) works. Isolating WDN segments causes pressure reduction and possible insufficient water supply conditions; the larger the number of valves (and segments) the larger the reliability of the system in face of segment isolation scenario. This contribution introduces some reliability indicators ranging from single node and time step up to the entire WDN, based on the explicit pressure-driven hydraulic simulation of the system under each segment isolation scenario over an operating cycle. Such mechanical reliability indicators are used to support the selection among optimal alternative IVS design solution obtained by minimizing the number of valves and the length of segments. The strategy is demonstrated on the real WDN serving the municipality of Oppegård (Norway).
The Hmm @ Real Feelings
Creators: name: Hunziker, Esther
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2021
Subjects: Real Feelings
The Hmm
MU Hybrid Art House

description: An experimental hybrid event as part of the Real Feelings exhibition at MU Hybrid Art. Emotions are interwoven with every aspect of daily life and technology has begun to engage with our emotions like never before. Real Feelings presents the works of international contemporary artists who challenge, provoke and explore the accelerating interactions between technology and emotion. Do emotions make us human and distinguish us from robots and other machines? Or does the digital age ask for, or even demand, a redefinition of this terminology? Speakers: Lola Gielen, Esther Hunziker, Bert Kappen, Marie Munk, Lisanne Pauw, Nadia Piet & Ocen Conijn, Ginevra Petrozzi, Minha Lee
It takes two to tango: combining asset specificity and uncertainty to explain the diversity of plural forms
Creators: name: Schnaider, Paula Sarita
name: Saes, Maria Sylvia Macchione
name: Raynaud, Emmanuel
name: Schnaider, Paula Sarita
name: Saes, Maria Sylvia Macchione
name: Raynaud, Emmanuel
Publisher: name: Unknown
Year: 2022
Subjects: subject: Agribusiness
subject: Agricultural and Food Policy
subject: International Relations/Trade
subject: asset specificity
subject: uncertainty
subject: food supply chains
subject: governance
subject: plural forms
subject: transaction costs

description: In this paper, we rely on an extended version of the traditional transaction cost economics (TCE) framework to explain the variety of plural forms in the governance of food supply chains. Relying on the interplay of two transactional attributes – asset specificity and uncertainty – we explore not only the existence of plural forms, but their empirical diversity. This aspect has been largely under-explored and very little has been done empirically so far in this respect, despite its empirical significance. From an organizational point of view, this diversity requires an explanation as they carry different governance properties. We propose that while both are important drivers for the prevalence of plural forms, each of them plays a different role in their composition. Whereas uncertainty determines the type of plural form, asset specificity determines the level of coordination within the plural form and sheds light in the relative weights of each organizational arrangement composing it. An embedded case study of the Korin firm in Brazil, a leading firm in the organic food market, illustrates.