cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
IL-10 Regulates Il12b Expression via Histone Deacetylation: Implications for Intestinal Macrophage Homeostasis
Creators: name: Sartor, R. Balfour
name: Matsuoka, Katsuyoshi
name: DeZoeten, Edwin F.
name: Mishima, Yoshiyuki
name: Sheikh, Shehzad Z.
name: Plevy, Scott E.
name: Kobayashi, Taku
name: Karp, Christopher L.
name: Russo, Steven M.
name: Collins, Colm
name: Ting, Jenny P.Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: To prevent excessive inflammatory responses to commensal microbes, intestinal macrophages unlike their systemic counterparts do not produce inflammatory cytokines in response to enteric bacteria. Consequently, loss of macrophage tolerance to the enteric microbiota plays a central role in the pathogenesis of the inflammatory bowel diseases. Therefore, we examined whether the hyporesponsive phenotype of intestinal macrophages is programmed by prior exposure to the microbiota. IL-10, but not in vivo exposure to the microbiota, programs intestinal macrophage tolerance, as wild-type (WT) colonic macrophages from germ free and specific-pathogen free (SPF) derived mice produce IL-10 but not IL-12 p40 when activated with enteric bacteria. Basal and activated IL-10 expression is mediated through a MyD88 dependent pathway. Conversely, colonic macrophages from germ free and SPF derived colitis-prone Il10−/− mice demonstrated robust production of IL-12 p40. Next, mechanisms through which IL-10 inhibits Il12b expression were investigated. While Il12b mRNA was transiently induced in LPS-activated WT bone marrow derived macrophages (BMDMs), expression persisted in Il10−/− BMDMs. There were no differences in nucleosome remodeling, mRNA stability, NF-κB activation or MAPK signaling to explain prolonged transcription of Il12b in Il10−/− BMDMs. However, acetylated histone H4 (AcH4) transiently associated with the Il12b promoter in WT BMDMs, whereas association of these factors was prolonged in Il10−/− BMDMs. Experiments utilizing histone deacetylase (HDAC) inhibitors and HDAC3 shRNA indicate that HDAC3 is involved in histone deacetylation of the Il12b promoter by IL-10. These results suggest that histone deacetylation on the Il12b promoter by HDAC3 mediates homeostatic effects of IL-10 in macrophages.
Effects of inter-annual freshwater inflow shifts on the community structure of estuarine decapods
Creators: name: ENCARNAÇÃO, João
name: LEITÃO, Tânia
name: MORAIS, Pedro
name: PILÓ, David
name: RANGE, Pedro
name: CHÍCHARO, Luis
name: CHÍCHARO, Maria A.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2013

description: The objective of this study was to evaluate how inter-annual changes in freshwater inputs have affected the decapod assemblages in the Guadiana estuary. Three major areas in the estuary were sampled during the summer, in 2001 (high inflow year and before the filling of the Alqueva dam), in 2002 (low inflow and after filling of the Alqueva dam), and in 2008 and 2009 (low inflow and after consolidation of the impacts of the Alqueva dam). A significant increase in total decapod densities was recorded for the entire estuary, but especially in the upper estuary, after the closure of the dam in 2002. Changes in salinity, turbidity and temperature, which were mainly due to changes in freshwater input and climatic influence (North Atlantic Oscillation index), had an important influence on the structure of the decapod crustacean assemblages. The major conclusions of the study were that, following the construction of the Alqueva dam and regularization of the freshwater inflow, the decapod crustacean community in the Guadiana estuary changed and a shift of the dominant decapod species to upper zones of the estuary happened. These changes, and the presence of the non-native Palaemon macrodactylus in 2008 and 2009, further enhance the importance of estuarine monitoring studies to improve ecologists' knowledge on distinguishing and understanding natural changes and anthropogenic impacts in the ecosystem.
Intracellular Insulin-like Growth Factor-1 Induces Bcl-2 Expression in Airway Epithelial Cells
Creators: name: Wright, Paul S.
name: Chen, Yangde
name: Randell, Scott H.
name: Tesfaigzi, Yohannes
name: Mebratu, Yohannes
name: Harris, Jennifer Foster
name: Chand, Hitendra S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Bcl-2, a prosurvival protein, regulates programmed cell death during development and repair processes, and can be oncogenic when cell proliferation is deregulated. The present study investigated what factors modulate Bcl-2 expression in airway epithelial cells and identified the pathways involved. Microarray analysis of mRNA from airway epithelial cells captured by laser microdissection showed that increased expression of IL-1β and IGF-1 coincided with induced Bcl-2 expression compared to controls. Treatment of cultured airway epithelial cells with IL-1β and IGF-1 induced Bcl-2 expression by increasing Bcl-2 mRNA stability with no discernible changes in promoter activity. Silencing the IGF-1 expression using shRNA showed that intracellular (IC)-IGF-1 was increasing Bcl-2 expression. Blocking EGFR or IGF-1R activation also suppressed IC-IGF-1, and abolished the Bcl-2 induction. Induced expression and co-localization of IC-IGF-1 and Bcl-2 were observed in airway epithelial cells of mice exposed to LPS or cigarette smoke and of patients with cystic fibrosis and chronic bronchitis but not in the respective controls. These studies demonstrate that IC-IGF-1 induces Bcl-2 expression in epithelial cells via IGF-1R and EGFR pathways, and targeting IC-IGF-1 could be beneficial to treat chronic airway diseases.
The evaluation of metal pollution on the littoral of El Jadida city (Morocco, Atlantic Ocean): using Arenicola grubii (Polychaeta: Nereididae) as biological indicator
Creators: name: ROUHI, Abdelali
name: SIF, Jamila
name: CHEMAA, Abdeljalil
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2013

description: This study allows the presentation of health condition of littoral of El jadida city by the analysis of the four heavy metals (Cd, Cu, Zn and Cr) for the polychaete Arenicola grubii. Samplings were carried out monthly from September 2003 to August 2004. Three physicochemical parameters of the seawater were also measured: pH, temperature and salinity. The obtained results show that there is a variation in space and time of the bioaccumulation. The site of Jorf Lasfar shows the most important values. Also this variation depends on seasons: the high values are registrated during dry season.
(1816) John Henderson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
NLRP1-Dependent Pyroptosis Leads to Acute Lung Injury and Morbidity in Mice
Creators: name: Hesker, Pamela R.
name: Snouwaert, John N.
name: Ting, Jenny P.Y.
name: Kovarova, Martina
name: Huang, Max T.
name: Nguyen, My Trang
name: Koller, Beverly H.
name: Xiang, Zhidan
name: Lommatzsch, Stephen E.
name: Jania, Leigh
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Acute inflammation in response to both exogenous and endogenous danger signals can lead to the assembly of cytoplasmic inflammasomes that stimulate the activation of caspase-1. Subsequently, caspase-1 facilitates the maturation and release of cytokines and also, under some circumstances, the induction of cell death by pyroptosis. Using a mouse line lacking expression of NLRP1, we show that assembly of this inflammasome in cells is triggered by a toxin from Anthrax and that it initiates caspase-1 activation and release of IL-1β. Furthermore, NLRP1 inflammasome activation also leads to cell death, which escalates over three days following exposure to the toxin and culminates in acute lung injury and death of the mice. We show that these events are not dependent on production of IL-1β by the inflammasome but are dependent on caspase-1 expression. In contrast, MDP mediated inflammasome formation is not dependent on NLRP1, but NLRP3. Taken together, our findings show that assembly of the NLRP1 inflammasome is sufficient to initiate pyroptosis, which subsequently leads to a self-amplifying cascade of cell injury within the lung from which the lung cannot recover, eventually resulting in catastrophic consequences for the organism.
Additional file 2 of Geospatial estimation of reproductive, maternal, newborn and child health indicators: a systematic review of methodological aspects of studies based on household surveys
Creators: name: Ferreira, Leonardo Z.
name: Cauane Blumenberg
name: C. Edson Utazi
name: Nilsen, Kristine
name: Hartwig, Fernando P.
name: Tatem, Andrew J.
name: Aluisio J. D. Barros
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Computational Biology

description: Additional file 2. PRISMA checklist.
Superradiantly stable non-extremal Reissner-Nordstrom black holes
Creators: name: Huang, Jia-Hui
name: Mai, Zhan-Feng
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The superradiant stability is investigated for non-extremal Reissner-Nordstrom black hole. We use an algebraic method to demonstrate that all non-extremal Reissner-Nordstrom black holes are superradiantly stable against a charged massive scalar perturbation. This improves the results obtained before for non-extremal Reissner-Nordstrom black holes.
RÉPARTITION DES ASCIDIES DES FONDS MEUBLES DE LA COTE SUD DE BRETAGNE
Creators: name: GLÉMAREC, Michel
name: MONNIOT, Claude
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1966

description: During a large number of dredgings in the soft sea bed off the south coast of Brittany, ten species were collected. These species included a new genus for the French coast: Cnemidocarpa sabulosa n. sp.; the species Polycarpa fibrosa mentioned for the French coast is split into three species one of which is new: P. kornogin.sp., with lusitanian affinities, P. cornata with arctic affinities and P. violacea which is only found in the littoral zone of the Channel. The study of granulometry represented by Shepard’s diagrams affords a precise ecological definition of the species found. Ascidians are good ecological indicators due to the strict limits in which they can survive.
Novel Role for Surfactant Protein A in Gastrointestinal Graft-versus-Host Disease
Creators: name: Nugent, Julia L.
name: Foster, W. Michael
name: Cardona, Diana M.
name: Wright, Jo Rae
name: Palmer, Scott M.
name: Gowdy, Kymberly M.
name: Mukherjee, Sambudho
name: Thomas, Joseph M.
name: Martinu, Tereza
name: Plevy, Scott E.
name: Pastva, Amy M.
name: Giamberardino, Charles
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Graft-versus-host-disease (GVHD) is a severe and frequent complication of allogeneic bone marrow transplantation (BMT) that involves the gastrointestinal tract and lungs. The pathobiology of GVHD is complex and involves immune cell recognition of host antigens as foreign. We hypothesize a central role for the collectin surfactant protein A (SP-A) in regulating the development of GVHD after allogeneic BMT.
Bathylaophonte gen. nov. from deep-sea hydrothermal vents and the polyphyly of Paronychocamptus (Copepoda: Harpacticoida)
Creators: name: LEE, Wonchoel
name: HUYS, Rony
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1999

description: Two new species of laophontid harpacticoids are described from deep-sea hydrothermal vents near the Azores in
 the Atlantic and north of Easter Island in the Pacific. Both species are placed in a new genus Bathylaophonte on account of
 the complex dorsal reticulation pattern on the cephalothorax and free body somites, the distinctive sexual dimorphism on
 both rami of P2-P4, and the relatively primitive setal formula of the swimming legs. The northwest European Laophonte
 faroensis, currently considered as species incerta in the family (Lang, 1948), is removed from its doubtful status and
 transferred to Bathylaophonte.
 The genus Paronychocamptus is identified as a polyphyletic taxon, comprising five lineages. Under the revised concept
 the genus is exclusively boreal, including only two European species, P. curticaudatus and P. nanus, and two North
 American species, P. huntsmani and P. wilsoni. The other species P. exiguus, P. leuke, P. proprius, P. connexus and
P. anomalus are reallocated to Onychocamptus Daday and three new genera. Paronychocamptus is tentatively regarded as
 the most likely sistergroup of Bathylaophonte.
 The brackish water species P. anomalus from Andhra Pradesh (India) is transferred to the genus Onychocamptus.
O. besnardi from Brazil and O. vitiospinulosa from China are removed from the synonymy of O. mohammed and reinstated
 as valid species. The primitive position of the genus and its relationship with Folioquinpes are discussed.
 P. proprius from California, is placed in a new genus Psammoplatypus together with Klieonychocamptus discipes which
 occupied an isolated position in the genus Klieonychocamptus. Psammoplatypus is placed in the genus group comprising
 Coullia, Phycolaophonte, Hemilaophonte and Robustunguis.
 The exiguus-group of Paronychocamptus, including P. exiguus from the Chatham Islands and P. connexus from Tierra del
 Fuego, is upgraded to generic level as Heteronychocamptus gen. nov. It is considered as most closely related to Pilifera,
 Pseudonychocamptus and Wedde
Prostaglandin E2 Produced by the Lung Augments the Effector Phase of Allergic Inflammation
Creators: name: Church, Rachel J.
name: Koller, Beverly H.
name: Jania, Leigh A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Elevated PGE2 is a hallmark of most inflammatory lesions. This lipid mediator can induce the cardinal signs of inflammation, and the beneficial actions of non-steroidal anti-inflammatory drugs are attributed to inhibition of cyclooxygenase COX-1 and COX-2, enzymes essential in the biosynthesis of PGE2 from arachidonic acid. However, both clinical studies and rodent models suggest that, in the asthmatic lung, PGE2 acts to restrain the immune response and limit physiological change secondary to inflammation. To directly address the role of PGE2 in the lung, we examined the development of disease in mice lacking microsomal prostaglandin E synthase 1 (mPGES1), which converts COX-1/COX-2 derived PGH2 to PGE2. We show that mPGES1 determines PGE2 levels in the naïve lung and is required for increases in PGE2 after ovalbumin (OVA) induced allergy. While loss of either COX-1 or COX-2 increases the disease severity, surprisingly mPGES1 −/− mice show reduced inflammation. However, an increase in serum IgE is still observed in the mPGES1 −/− mice, suggesting that loss of PGE2 does not impair induction of a TH2 response. Furthermore, mPGES1 −/− mice expressing a transgenic OVA-specific T cell receptor are also protected, indicating that PGE2 acts primarily after challenge with inhaled antigen. PGE2 produced by the lung plays the critical role in this response, as loss of lung mPGES1 is sufficient to protect against disease. Together this supports a model in which mPGES1-dependent PGE2 produced by populations of cells native to the lung contributes to the effector phase of some allergic responses.
title: Fabrication of large area polymer microfilters via vacuum assisted UV micro-molding
Creators: name: Hernández-Castro, Javier Alejandro
name: Li, Kebin
name: Meunier, Anne
name: Veres, Teodor
name: Juncker, David
Publisher: name: National Research Council Canada
Year: 2017

description: MicroTAS 2017, 22-26 October 2017, Dublin, Ireland
First report of Loricifera from the Indian Ocean: a new Rugiloricus-species represented by a hermaphrodite
Creators: name: KRISTENSEN, Reinhardt Møbjerg
name: NEVES, Ricardo Cardoso
name: GAD, Gunnar
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2013

description: A hermaphroditic adult of a new species of Rugiloricus was discovered in the deep sea of the Channel of Mozambique at 3,400 m water depth. This is the first report of Loricifera from the Indian Ocean. The adult of R. renaudae sp. nov. differs from similar species in having a mouth cone of medium size with a long, narrow, distally pointed first section; a mouth opening surrounded by four small denticle-like oral teeth; the long distal parts of the clavoscalids with a fine ventral serration; the proximal parts of the clavoscalids with a dorsal serration and stalked bases; a short, thin, transformed ventral pair of clavoscalids which partly looks like the spinoscalids of the second row; these spinoscalids divided into four segments, the three distal segments being laterally winged with serrated edges; the type B scalids of the fourth row end in indistinct hooks; the bristle-like scalids of the third to eighth rows with a fine serration; the trichoscalids differ slightly in length, but not in structure; the lorica plicae with double primary ridges and a single secondary ridge; a very small anal cone with a pair of narrow standing warts. The hermaphroditic adults have a single ovary and a single testis. These findings support earlier hypotheses regarding the life cycle of other Rugiloricus-species.
GEORGE CRUIKSHANK. The Evils of Drunkenness as Sketched by George Cruikshank. With Reproductions of his Etchings The Bottle and The Drunkard’s Children; 16 plates.
Creators: name: Keller, Mark
Publisher: name: No Publisher Supplied
Year: 1943

description: An article published in the Quarterly Journal of Studies on Alcohol and in the volume entitled Classics of the Alcohol Literature, the primary source of many seminal articles related to Alcohol Studies.
Probing beyond the laser coherence time in optical clock comparisons
Creators: name: Hume, David B.
name: Leibrandt, David R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We develop differential measurement protocols that circumvent the laser noise limit in the stability of optical clock comparisons by synchronous probing of two clocks using phase-locked local oscillators. This allows for probe times longer than the laser coherence time, avoids the Dick effect, and supports Heisenberg-limited measurement precision. We present protocols for such frequency comparisons and develop numerical simulations of the protocols with realistic noise sources. These methods provide a route to reduce frequency ratio measurement durations by more than an order of magnitude.
description: Replaced with published version. 8 pages, 4 figures
Additional file 1 of Exploring and detecting predictors associated with survival and mortality of cervical cancer patients: a 10-year retrospective study
Creators: name: Muneeha, Shaba
name: Chaudhary, Raushan Kumar
name: Shetty, Vijith Vittal
name: Patil, Soumya
name: Mateti, Uday Venkat
Publisher: name: figshare
Year: 2025
Subjects: Medicine
Cell Biology
Biotechnology
Mathematical Sciences not elsewhere classified
Developmental Biology
Cancer

description: Additional file 1.
A revision of Acrenhydrosoma (Copepoda, Harpacticoida) with the establishment of Dyacrenhydrosoma gen. nov. and Paracrenhydrosoma gen. nov. and descriptions of two new species
Creators: name: GEE, J. Michael
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1999

description: Acrenhydrosoma perplexa is redescribed from cotype and other material. It possesses only two setae on the
 antennal exopod, a mandibular palp with three setae, and a maxillulary coxal endite partially fused to a basis which bears
 only three setae. The P1 endopod-2 has two armature elements and the P5 baseoendopod, in both sexes, has an outer seta
 borne on a submarginal peduncle. The male P5 exopod bears only two setae. The posterior margin of the preanal somite has
 a dorsal, dentate, pseudoperculum overlaying the operculum which is situated near the anterior margin of the anal somite.
A new species, with a urosome structure similar to Acrenhydrosoma is described from mangrove forests in S.E. Asia and
 is placed in Dyacrenhydrosoma gen. nov. as D. breviseta sp. nov.. It can be distinguished from Acrenhydrosoma by the
 absence of a seta on the abexopodal margin of the antennal allobasis, a maxillulary coxal endite (represented by 1 seta)
 completely fused to the basis which bears only two setae, reduced armature of the maxilla, short terminal setae without
 penicillate tips on P1 exopod-3, only two setae on P2-P4 endopod-2, a female P5 baseoendopod with only one inner spine
 and an exopod with only 2 setae.
 Material from northern Norway, attributed to Acrenhydrosoma perplexa by T. Scott (1903) is described and placed in
 Paracrenhydrosoma gen. nov. as P. normani sp. nov. It is very similar to Acrenhydrosoma maccalli but can be distinguished
 from it by features on the P5. A. maccalli and A. karlingi are moved to Paracrenhydrosoma which can be distinguished from
 Acrenhydrosoma by the absence of a pseudoperculum on the preanal somite, and also by an operculum situated in the
 posterior half of the anal somite, a broader, emarginate rostrum, a mandibular palp with four setae, a maxillulary coxal endite
 (bearing two setae) completely separate from a basis bearing six setae, a P1 endopod-2 with three setae and a female P5
 exopod with two setae.
(1812) Jane Brydson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A tumor-derived type III collagen-rich ECM niche regulates tumor cell dormancy
Creators: name: Di Martino, Julie S
name: Nobre, Ana Rita
name: Mondal, Chandrani
name: Taha, Isra
name: Farias, Eduardo F
name: Fertig, Elana J
name: Naba, Alexandra
name: Aguirre-Ghiso, Julio A
name: Bravo-Cordero, Jose Javier
Publisher: name: University of Illinois at Chicago
Year: 2023
Subjects: Uncategorized

description: Cancer cells disseminate and seed in distant organs, where they can remain dormant for many years before forming clinically detectable metastases. Here we studied how disseminated tumor cells sense and remodel the extracellular matrix (ECM) to sustain dormancy. ECM proteomics revealed that dormant cancer cells assemble a type III collagen-enriched ECM niche. Tumor-derived type III collagen is required to sustain tumor dormancy, as its disruption restores tumor cell proliferation through DDR1-mediated STAT1 signaling. Second-harmonic generation two-photon microscopy further revealed that the dormancy-to-reactivation transition is accompanied by changes in type III collagen architecture and abundance. Analysis of clinical samples revealed that type III collagen levels were increased in tumors from patients with lymph node-negative head and neck squamous cell carcinoma compared to patients who were positive for lymph node colonization. Our data support the idea that the manipulation of these mechanisms could serve as a barrier to metastasis through disseminated tumor cell dormancy induction.
title: Inverse geochemical modelling demonstrates how weathering and ion surface exchange control groundwater chemistry in the Pra Basin (Ghana)
Creators: name:  Manu , Evans
name:  Kühn , Michael
name:  Kempka , Thomas
name:  De Lucia , Marco
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: Effective implementation of sustainable water resources management is one of the daunting tasks in most parts of the world. The Pra Basin has a high economic importance, hosting most of Ghana’s mineral resources, including gold, bauxite, iron, manganese, and diamonds. Currently, the basin is faced with several water resources management issues, especially pollution arising from the discharge of untreated waste into water bodies and illegal artisanal mining. Considering this background, the present study aims to determine the geochemical processes controlling the Pra Basin’s groundwater chemistry and provide the baseline information for groundwater management. A total of 65 groundwater samples sourced from boreholes (depths >30 m) were analysed for their physico-chemical parameters. Hierarchical cluster analysis and inverse geochemical modelling were applied to the hydrochemical data to investigate the sources of variation in groundwater hydrochemistry in the area. Three major geochemical processes were determined as drivers for groundwater chemical evolution: dissolution of carbonates, weathering of silicates and ion exchange. Inverse modelling underlines the dissolution of primary biotite, dolomite, halite, plagioclase, and precipitation of secondary calcite and gypsum as the apparent dominating reactions, reflecting the general groundwater chemistry in the basin. Groundwater evolves, namely from CaHCO3 to NaHCO3, and finally into NaCl water along its flow path. The presented results improve our understanding of the hydrochemical controls of the groundwater resources and support the design and implementation of sustainable water resources management strategies for the Pra Basin.
NOVOLAOPHONTE VIATORUM N.GEN., N.SP. (CRUSTACEA, COPEPODA, HARPACTICOIDA) DI ACQUE INTERSTIZIALI LITORALI DEL MASSACHUSETTS
Creators: name: COTTOREILI, Vezio
name: SAPORITO, Paola Elisabetta
name: FACCETTI, Andrea Corrado
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1983

Abstract
General Finnish DMP guidance
Creators: name: Tuuli-Project
Publisher: name: Zenodo
Year: 2018
Subjects: Data management plan
DMP
Guidance

description: Please check the latest version of the General Finnish DMP guidance https://doi.org/10.5281/zenodo.3629371 Updated 12.12.2018. National guidance and questions that assist with data management planning have been updated in 28.11.2018. A group of experts co-operated in writing the guidance. The members of the group came from Finnish universities, research institutions and The Academy of Finland. The work was coordinated by Tuuli office, which is funded (2015-2018) by Ministry in Education and Culture. The questions and guidance have been modified based on user feedback to make them more explicit and easier to understand. The questions and guidance will be updated annually in the future as well. As the expertise of the users increases it would be useful that the structure of the guidance stays the same. From 2019 the Finnish national guidance follows the Core Requirements for Data management Plans launched by Science Europe. (1)  The guidance is in English, Finnish and Swedish. Cite as: Tuuli-project. (2018, Decenber 12). General Finnish DMP guidance. Zenodo: https://doi.org/10.5281/zenodo.1035190. References (1) Science Europe, (2018) Practical Guide to the International Alignment of Research Data Managemen, https://www.scienceeurope.org/wp-content/uploads/2018/12/SE_RDM_Practical_Guide_Final.pdf
The warm CO gas along the UV-heated outflow cavity walls: a possible interpretation for the Herschel/PACS CO spectra of embedded YSOs
Creators: name: Lee, Seokho
name: Lee, Jeong-Eun
name: Bergin, Edwin A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: A fraction of the mid-$J$ ($J$= 14--13 to $J$= 24--23) CO emission detected by the \textit{Herschel}/PACS observations of embedded young stellar objects (YSOs) has been attributed to the UV-heated outflow cavity walls. We have applied our newly developed self-consistent models of Photon-Dominated Region (PDR) and non-local thermal equilibrium line Radiative transfer In general Grid (RIG) to the \textit{Herschel} FIR observations of 27 low mass YSOs and one intermediate mass YSO, NGC7129-FIRS2. When the contribution of the hot component (traced by transitions of $J> 24$) is removed, the rotational temperature of the warm component is nearly constant with $\sim250$ K. This can be reproduced by the outflow cavity wall ($n \geq 10^6\, \mathrm{cm}^{-3}$, $\log G_{0}/n \geq-4.5$, $\mathrm{log} G_0\ge 3$, $T_{\rm gas} \ge 300 $K, and X(CO)$ \ge 10^{-5}$) heated by a UV radiation field with a black body temperature of 15,000 K or 10,000 K. However, a shock model combined with an internal PDR will be required to determine the quantitative contribution of a PDR relative to a shock to the mid-$J$ CO emission.
description: accepted for publication in Astrophysical Journal
Receptor Cross-Talk Spatially Restricts p-ERK during TLR4 Stimulation of Autoreactive B Cells
Creators: name: Wagner, Nikki J.
name: Krum, Kristen N.
name: Jones, Shannon Z.
name: Rutan, Jennifer A.
name: Lee, Sang Ryul
name: Monteith, Andrew J.
name: Kang, Sun Ah
name: Roques, Jose R.
name: Clarke, Stephen H.
name: Vilen, Barbara J.
name: Kilmon, Michelle A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: To maintain tolerance, autoreactive B cells must regulate signal transduction from the B cell receptor and Toll-like receptors. We recently identified that dendritic cells and macrophages regulate autoreactive cells during TLR4 activation by releasing IL-6 and soluble CD40L (sCD40L). These cytokines selectively repress antibody secretion from autoreactive, but not antigenically naïve, B cells. How IL-6 and sCD40L repress autoantibody production is unknown. In this paper, we show that IL-6 and sCD40L are required for low-affinity/avidity autoreactive B cells to maintain tolerance through a mechanism involving receptor crosstalk between the BCR, TLR4, and the IL-6 receptor or CD40. We show that acute signaling through IL-6 receptor or CD40 integrates with chronic BCR-mediated ERK activation to restrict pERK from the nucleus and repress TLR4-induced Blimp-1 and XBP-1 expression. Tolerance is disrupted in 2-12H/MRL/lpr mice where IL-6 and sCD40L fail to spatially restrict pERK and fail to repress TLR4-induced Ig secretion. In the case of CD40, acute signaling in B cells from 2-12H/MRL/lpr mice is intact, but the chronic activation of pERK emanating from the BCR is attenuated. Re-establishing chronically active ERK through retroviral expression of constitutively active MEK1 restores tolerance upon sCD40L, but not IL-6, stimulation indicating that regulation by IL-6 requires another signaling effector. These data define the molecular basis for the regulation of low-affinity autoreactive B cells during TLR4 stimulation, they explain how autoreactive but not naïve B cells are repressed by IL-6 and sCD40L, and they identify B cell defects in lupus-prone mice that lead to TLR4-induced autoantibody production.
Additional file 1 of Early warning signals in psychopathology: what do they tell?
Creators: name: Schreuder, Marieke J.
name: Hartman, Catharina A.
name: Sandip V. George
name: Menne-Lothmann, Claudia
name: Decoster, Jeroen
name: Winkel, Ruud Van
name: Delespaul, Philippe
name: Hert, Marc De
name: Derom, Catherine
name: Thiery, Evert
name: Rutten, Bart P. F.
name: Jacobs, Nele
name: Os, Jim Van
name: Wigman, Johanna T. W.
name: Wichers, Marieke
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1. Reports details on the sample composition, and particularly, the overlap between samples; details concerning the main analyses (e.g. effects that were not of primary interest; unstandardized effects); and results from post-hoc analyses where the models of the study by van de Leemput et al. [4] and models of the current study are compared and fitted to both datasets.
Characterization of non-differentiable points in a function by Fractional derivative of Jumarrie type
Creators: name: Ghosh, Uttam
name: Sengupta, Srijan
name: Sarkar, Susmita
name: Das, Shantanu
Publisher: name: arXiv
Year: 2015
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics

description: There are many functions which are continuous everywhere but not differentiable at some points, like in physical systems of ECG, EEG plots, and cracks pattern and for several other phenomena. Using classical calculus those functions cannot be characterized-especially at the non-differentiable points. To characterize those functions the concept of Fractional Derivative is used. From the analysis it is established that though those functions are unreachable at the non-differentiable points, in classical sense but can be characterized using Fractional derivative. In this paper we demonstrate use of modified Riemann-Liouvelli derivative by Jumarrie to calculate the fractional derivatives of the non-differentiable points of a function, which may be one step to characterize and distinguish and compare several non-differentiable points in a system or across the systems. This method we are extending to differentiate various ECG graphs by quantification of non-differentiable points; is useful method in differential diagnostic. Each steps of calculating these fractional derivatives is elaborated.
description: 17 pages, 14 figures, http://euroessays.org/wp-content/uploads/2015/03/EJAE-340.html
LA SEXUALISATION DU STOLON CHEZ SYLLIS SPONGICOLA GRÜBE
Creators: name: WISSOCQ, Jean-Claude
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1966

description: For the first time, in Syllinae, and particularly, in Syllis spongicola, we have described a migration of the male or female gametes, from the stock towards the stolon. The gonads only grow in segments of the stock. The stolon receives nearly all the gametes emanating from the stock and allows their expulsion.
The germ cells migration takes place by means of a septal aperture. This appears, beneath the ventral vessel, at the end of the germ cells maturation.
CONTRIBUTION A L'ÉTUDE DES RAPPORTS ENTRE VARIABILITÉ ET ÉCOLOGIE CHEZ UN PROSOBRANCHE INTERTIDAL LITTORINA OBTUSATA (L.). V.  RECHERCHES DANS LE PLYMOUTH SOUND (ANGLETERRE S.-W.)
Creators: name: SACCHI, C.F.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1966

Abstract
title: Democratic governance through intermediary bodies: a case study of third sector interfaces in Scotland
Creators: name: Cullingworth, Jane
Publisher: name: University of Glasgow
Year: 2020
Subjects: subject: democratic governance, third sector, intermediary bodies, third sector independence, third sector representation, governance networks, community planning, case study.

description: This research focuses on third sector interfaces (TSIs) as a site through which to examine the relationship between the third sector and the state in Scotland. The TSI model was instituted by the Scottish Government in 2011 in each of Scotland’s 32 local authorities with a remit to build sector capacity, support volunteerism, encourage social enterprise, and represent the sector in community planning. Through its participation in state-initiated local governance networks, like Community Planning Partnerships, the sector has a prominence that was unthinkable just twenty years ago. This research study explores the impact of a TSI’s participation in state-initiated local governance networks, focusing on the TSI’s independence from the state and its representation of the sector. Using a qualitative interpretivist approach, 44 semi-structured interviews were conducted (13 with national stakeholders, 19 with local stakeholders, and 12 with TSI staff) and 16 local governance meetings observed. A large urban TSI was selected for the case study. Four key themes emerged from an iterative thematic analysis. One, that local governance sits within a space, literal and figurative, where representative and participatory democracy meet. Through its participation, the TSI is brought closer to the state implicating it in statutory decision making. Two, the TSI model is an example of a “civil servant construct” channelling the sector’s participation in local governance networks through structures that mirror state priorities, compromising the independence of the TSI and complicating its representation role. Three, the TSI’s closeness to the state creates distrust within the third sector which in turn weakens its legitimacy in representing the sector. Four, local governance spaces embody a culture of “managed talk” compromising the TSI’s ability to be activist and shaping its participation through a state logic. The study suggests that there is an impact on both the TSI’s independence from the state and the ways in which it represents the third sector. The current state approach to engaging the third sector risks “manufacturing civil society” (Brandsen, et al., 2014) where the sector becomes a reflection of the state rather than an expression of civil society. Recommendations from the study include the need for democratic governance spaces to be shaped collaboratively by the state and civil society, the state to reconsider its instrumental approach to the third sector, the third sector to assert its independence, and intermediary bodies to act as facilitators rather than representatives.
(1809) Ann [Crawford]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Structural and magnetic properties of MnCo1-xFexSi alloys
Creators: name: Chen, J. H.
name: Wei, Z. Y.
name: Liu, E. K.
name: Qi, X.
name: Wang, W. H.
name: Wu, G. H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The crystal structures, martensitic structural transitions and magnetic properties of MnCo1-xFexSi (0 <= x <= 0.50) alloys were studied by differential scanning calorimetry (DSC), x-ray powder diffraction (XRD) and magnetic measurements. In high-temperature paramagnetic state, the alloys undergo a martensitic structural transitions from the Ni2In-type hexagonal parent phase to the TiNiSi-type orthorhombic martensite. Both the martensitic transition temperature (TM) and Curie temperatures of martensite (T_C^M) decrease with increasing Fe content. The introduced Fe atoms establish ferromagnetic (FM) coupling between Fe-Mn atoms and destroy the double spiral antiferromagnetic (AFM) coupling in MnCoSi compound, resulting in a magnetic change in the martensite phase from a spiral AFM state to a FM state. For the alloys with x = 0.10, 0.15 and 0.20, a metamagnetic transition was observed in between the two magnetic states. A magnetostructural phase diagram of MnCo1-xFexSi (0 <= x <= 0.50) alloys was proposed.
description: 18 pages, 6 figs, submitted to JMMM
Circulating Fibrocytes Prepare the Lung for Cancer Metastasis by Recruiting Ly-6C+ Monocytes Via CCL2
Creators: name: Palmieri, Daniela A.
name: Serody, Jonathan S.
name: McCook, Everett C.
name: Van Deventer, Hendrik W.
name: Wu, Qing Ping
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Fibrocytes are circulating, hematopoietic cells that express CD45 and Col1a1. They contribute to wound healing and several fibrosing disorders by mechanisms that are poorly understood. In this report, we demonstrate that fibrocytes predispose the lung to B16-F10 metastasis by recruiting Ly-6C+ monocytes. To do so, we isolated fibrocytes expressing CD45, CD11b, CD13, and Col1a1 from the lungs of wild type (WT) and Ccr5−/− mice. WT but not Ccr5−/− fibrocytes increased the number of metastatic foci when injected into Ccr5−/− mice (73 ± 2 versus 32 ± 5; p < 0.001). This process was MMP9 dependent. Injection of WT enhanced GFP+ fibrocytes also increased the number of Gr-1Int, CD11b+, and enhanced GFP− monocytes. Like premetastatic-niche monocytes, these recruited cells expressed Ly-6C, CD117, and CD45. The transfer of these cells into Ccr5−/− mice enhanced metastasis (90 ± 8 foci) compared with B cells (27 ± 2), immature dendritic cells (31 ± 6), or alveolar macrophages (28 ± 3; p < 0.05). WT and Ccl2−/− fibrocytes also stimulated Ccl2 expression in the lung by 2.07 ± 0.05- and 2.78 ± 0.36-fold compared with Ccr5−/− fibrocytes (1.0 ± 0.06; p < 0.05). Furthermore, WT fibrocytes did not increase Ly-6C+ monocytes in Ccr2−/− mice and did not promote metastasis in either Ccr2−/− or Ccl2−/− mice. These data support our hypothesis that fibrocytes contribute to premetastatic conditioning by recruiting Ly-6C+ monocytes in a chemokine-dependent process. This work links metastatic risk to conditions that mobilize fibrocytes, such as inflammation and wound repair.
The structure of the benthic macrofauna collected across a transect at the central chile shelf and relationships with giant sulfur bacteria Thioploca spp. mats.
Creators: name: CARRASCO, Franklin D.
name: GALLARDO, Víctor A.
name: BALTAZAR, Mario
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1999

description: The analysis of the community structure of macrobenthic (>0.25 mm) assemblages collected from a transect in
 the Central Chile shelf and the relationships with sulphur bacteria Thioploca spp. was performed. Samples were obtained in
 April 1982 (southern Autumn) with a 0.1 m2 Smith-McIntyre grab at three cross-shelf stations off Concepción Bay, central
 Chile. Sediments consisted of fine muds (>95% silt-clay) with high (>15%) total organic matter. Here bottom waters showed
 the typical characteristics of the pole-ward flowing Sub-Surface Equatorial Waters, i.e., higher salinity than those at surface
 (>34.5%o) and low oxygen (<1.0 ml O2 l-1). Filaments of the giant bacteria Thioploca spp. were moderately collected at
 station E1 (31.9 g m-2 wet weight at 75 m depth), were scarce at station E2 (2.3 g m-2 w.wt. at 100 m), and absent at station
 E3 (121 m). In all sites macrofaunal composition was comparable, with a low total species richness, a low species diversity
 (27 species), and a high dominance. Average figures for abundance ranged from 77,880 ind m-2 at E1 to 14,770 ind m-2 at
 E3. Faunal biomass (w. wt.) ranged from 110 g m-2 at E1 to 32 g m-2 at E3. Polychaeta was the most abundant taxon (78%
 of the total), with Paraprionospio pinnata as the dominant species in all stations. Statistical analyses indicated significant
 differences among all sites, but in particular between E1, with a larger population of Thioploca spp., and the deeper E2 and
 E3 sites where Thioploca was scarse and absent, respectively.
OBSOPOEUS. Art of Drinking. Translated from the Latin by Helen F. Simpson. A Specimen of the Sixteenth-Century German Drink Literature.
Creators: name: Jellinek, E. M. (Elvin Morton)
Publisher: name: No Publisher Supplied
Year: 1953

description: An article published in the Quarterly Journal of Studies on Alcohol and in the volume entitled Classics of the Alcohol Literature, the primary source of many seminal articles related to Alcohol Studies.
Cord Factor and Peptidoglycan Recapitulate the Th17-Promoting Adjuvant Activity of Mycobacteria through Mincle/CARD9 Signaling and the Inflammasome
Creators: name: Hieny, Sara
name: Sher, Alan
name: Ting, Jenny P.Y.
name: Besra, Gurdyal S.
name: Yamasaki, Sho
name: Gurcha, Sudagar S.
name: Caspar, Pat
name: Lin, Xin
name: Feng, Carl G.
name: Oland, Sandy
name: Mayer-Barber, Katrin D.
name: Cerundolo, Vincenzo
name: Shenderov, Kevin
name: Barber, Daniel L.
name: Trinchieri, Giorgio
name: Jankovic, Dragana
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Although adjuvants are critical vaccine components, their modes of action are poorly understood. Here, we investigated the mechanisms by which the heat-killed mycobacteria in complete Freund’s adjuvant (CFA) promote T helper 17 (Th17) CD4+ T cell responses. We found that IL-17 secretion by CD4+ T cells following CFA immunization requires MyD88 and IL-1β/IL-1 receptor (IL-1R) signaling. Through measurement of antigen-specific responses after adoptive transfer of OTII cells, we confirmed that MyD88-dependent signaling controls Th17 differentiation rather than simply production of IL-17. Additional experiments showed that CFA-induced Th17 differentiation involves IL-1β processing by the inflammasome, as mice lacking caspase 1, ASC, or NLRP3 exhibit partially defective responses after immunization. Biochemical fractionation studies further revealed that peptidoglycan is the major component of heat-killed mycobacteria responsible for inflammasome activation. By assaying Il1b transcripts in the injection site skin of CFA-immunized mice, we found that signaling through the adaptor molecule CARD9 plays a major role in triggering pro-IL-1β expression. Moreover, we demonstrated that recognition of the mycobacterial glycolipid trehalose dimycolate (cord factor) by the C type lectin receptor mincle partially explains this CARD9 requirement. Importantly, purified peptidoglycan and cord factor administered in mineral oil synergized to recapitulate the Th17-promoting activity of CFA, and, as expected, this response was diminished in caspase 1-and CARD9-deficient mice. Taken together, these findings suggest a general strategy for the rational design of Th17-skewing adjuvants by combining agonists of the CARD9 pathway with inflammasome activators.