cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Sull'impugnazione del lodo libero
Creators: name: Arrigoni, Caterina
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2011
Subjects: IUS/15 Diritto processuale civile

description: L’autore, dopo un rapido inquadramento sistematico, si propone di ripercorrere gli orientamenti dottrinali e giurisprudenziali in materia di impugnazione del lodo libero prima e dopo l’inserimento nell'’impianto codicistico dell’art. 808-ter c.p.c. Valorizza la visione processualistica del fenomeno, ove in ragione della nuova norma i motivi di annullamento del lodo sono modellati su quelli dell’impugnazione per nullità, ed evidenzia la rilevanza del principio del contraddittorio nell’arbitrato libero non più inteso in senso esclusivamente sostanziale, ma quale garanzia ineliminabile in un giusto processo arbitrale.
Plant invasions at different scales : two representative case studies [Kumultative Dissertation]
Creators: name: Wohlwend, Michael Rudolf
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 580

description: Die Dissertation mit dem Titel "Invasionsprozesse auf unterschiedlichen Skalen – zwei repräsentative Fallstudien" ist das Ergebnis der Arbeit von Michael Wohlwend in der Arbeitsgruppe Räumliche Interaktionsökologie. Sie stellt zwei Studien vor, die in den größeren Kontext der Forschung zu nicht-heimischen Pflanzenarten eingebettet sind. In der ersten, einem Renaturierungsexperimentes auf der nordamerikanischen Prärie, das sich mit einer invasiven Pflanze namens L. cuneata befasst, wird die Rolle der Ankunftsreihenfolge für den Etablierungserfolg und das Ergebnis der Renaturierung hervorgehoben. Im zweiten Teil werden die beiden größten Datensätze über nicht-heimische Pflanzenarten im Pazifik vereinheitlicht, um die bisher größte Datenbank, PacIFlora, zu kreieren. Es werden große Muster der Verteilung von Arten im Pazifik visualisiert. Die Bedeutung der verschiedenen Faktoren für die Einschleppung und den Etablierungserfolg nicht heimischer Arten wird hervorgehoben.
description: The dissertation entitled “Plant invasions at different scales - two representative case studies” is a result of Michael Wohlwend’s work at the Spatial Interaction Ecology group. It introduces two case studies, encapsulated in the larger context of non-native plant species research. In the first, a restoration experiment located on the North American prairie, close to St. Louis, Missouri, which deals with a noxious invasive plant called Lespedeza cuneata, the role of arrival order on invader success and restoration outcome is underlined. In the second, the two largest datasets on non-native plant species in the Pacific, GloNAF and PIER are harmonized to provide the most complete database to date, PacIFlora. Large patterns of non-native plant species distribution within the pacific is visualized. A subset of this dataset is analysed, outlining the importance of different drivers on introduction and establishment success of non-native species.
Combinatorial realizations of crystals via torus actions on quiver varieties
Creators: name: Sam, Steven V
name: Tingley, Peter
Publisher: name: arXiv
Year: 2012
Subjects: subject: Combinatorics (math.CO)
subject: Quantum Algebra (math.QA)
subject: FOS: Mathematics
subject: 05E10, 17B10

description: Consider Kashiwara's crystal associated to a highest weight representation of a symmetric Kac-Moody algebra. There is a geometric realization of this object using Nakajima's quiver varieties, but in many particular cases it can also be realized by elementary combinatorial methods. Here we propose a framework for extracting combinatorial realizations from the geometric picture: We construct certain torus actions on the quiver varieties and use Morse theory to index the irreducible components by connected components of the subvariety of torus fixed points. We then discuss the case of affine sl(n). There the fixed point components are just points, and are naturally indexed by multi-partitions. There is some choice in our construction, leading to a family of combinatorial models for each highest weight crystal. Applying this construction to the crystal of the fundamental representation recovers a family of combinatorial realizations recently constructed by Fayers. This gives a more conceptual proof of Fayers' result as well as a generalization to higher level. We also discuss a relationship with Nakajima's monomial crystal.
description: 23 pages, v2: added Section 8 on monomial crystals and some references; v3: many small corrections
La storia del debito pubblico in Italia
Creators: name: Carnazza, Giovanni
Publisher: name: Argomenti
Year: 2021

description: Il problema del debito pubblico non è nuovo per il nostro paese e, nel corso del tempo, il suo rapporto rispetto al Pil è sempre stato elevato e persistente. Alla fine degli anni Settanta, una volta venute meno quelle caratteristiche che avevano contenuto l’incremento di tale rapporto, come la significativa crescita economica e un contenuto tasso di interesse favorito da una politica monetaria accomodante, si assiste progressivamente a un suo aumento significativo non solo in termini relativi ma anche assoluti. Scomponendo i contributi apportati dalle politiche di bilancio e dalla crescita nominale del prodotto nell’influenzare la dinamica del rapporto debito/Pil, tale lavoro vuole ricostruire, in una prospettiva storica (1861-2019), le ragioni alla base della sua evoluzione.
description: Argomenti, online first
A tool to assess capacity to consent for treatment among homeless populations with problematic substance use
Creators: name: Taylor, Darlene Lois
Publisher: name: University of British Columbia
Year: 2014

description: BACKGROUND: Individuals who misuse substances and who are homeless or unstably housed (IMSH) are at risk of acquiring communicable diseases such as HIV, sexually transmitted infections and blood-borne infections and have greater medical needs than the general population. However, obtaining informed consent for health care can be challenging as many IMSH have impaired cognition due to the effects of substances. This dissertation describes the development and validation process used to create a psychometric instrument that measures capacity to consent for health care (CTC-HC) among IMSH. METHODS: Forty-six qualitative interviews were conducted with 19 nurses who deliver care to IMSH and 27 IMSH to identify concepts that should be included in a capacity assessment instrument. A panel of experts reviewed possible items to obtain content and face validity. The instrument was administered to 302 IMSH. Construct and criterion validity were assessed by comparing the results of the new instrument to 1) a psychiatric assessment and 2) scores obtained from the MacArthur Competency Assessment Tool for Treatment. Item analysis was conducted to determine the reliability of the instrument and a confirmatory factor analysis was conducted. The areas under the receiver operating characteristic curves (ROC) were calculated to assess criterion validity. A diagnostic cut-off value was created using the corresponding points on the ROC. RESULTS: The final Capacity Assessment Instrument for People who misuse Substances (CAIPS) consists of items that address understanding, voluntariness, orientation, ability to communicate, sustained attention, distorted reality, appreciation, reasoning, expression of choice, decision making demands, and physical indication of substance use. These concepts were incorporated into an 11-item instrument that scores items on a four-point Likert scale. The CAIPS instrument demonstrated good internal reliability (Cronbach’s alpha: 0.861 – 0.893) and inter-observer reliability (weighted kappa statistic of 0.657). The factor analysis confirmed the unidimensionality assumption and the ROC analysis revealed that the CAIPS has a sensitivity of .75 - .81 and a specificity of .63 - .51. CONCLUSIONS: CAIPS is a reliable tool with moderate validity and is the first validated capacity assessment instrument available for clinicians to assess CTC-HC among IMSH.
Editoriale: Sostenibilità e [in]sicurezza alimentare: un percorso di analisi interdisciplinare
Creators: name: Cangiotti, Marco
name: Viganò, Elena
Publisher: name: Argomenti
Year: 2021

description: Editoriale per il numero speciale 18/2021
description: Argomenti, N. 18 (2021): gennaio - aprile
Ore- and Fan-type heavy subgraphs for Hamiltonicity of 2-connected graphs
Creators: name: Ning, Bo
name: Zhang, Shenggui
Publisher: name: arXiv
Year: 2012
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05C38, 05C45

description: Bedrossian characterized all pairs of forbidden subgraphs for a 2-connected graph to be Hamiltonian. Instead of forbidding some induced subgraphs, we relax the conditions for graphs to be Hamiltonian by restricting Ore- and Fan-type degree conditions on these induced subgraphs. Let $G$ be a graph on $n$ vertices and $H$ be an induced subgraph of $G$. $H$ is called \emph{o}-heavy if there are two nonadjacent vertices in $H$ with degree sum at least $n$, and is called $f$-heavy if for every two vertices $u,v\in V(H)$, $d_{H}(u,v)=2$ implies that $\max\{d(u),d(v)\}\geq n/2$. We say that $G$ is $H$-\emph{o}-heavy ($H$-\emph{f}-heavy) if every induced subgraph of $G$ isomorphic to $H$ is \emph{o}-heavy (\emph{f}-heavy). In this paper we characterize all connected graphs $R$ and $S$ other than $P_3$ such that every 2-connected $R$-\emph{f}-heavy and $S$-\emph{f}-heavy ($R$-\emph{o}-heavy and $S$-\emph{f}-heavy, $R$-\emph{f}-heavy and $S$-free) graph is Hamiltonian. Our results extend several previous theorems on forbidden subgraph conditions and heavy subgraph conditions for Hamiltonicity of 2-connected graphs.
description: 21 pages, 2 figures
Artificial application systems for Thysanoptera : key to new fields of research
Creators: name: Jilge, Marcus
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: 580

description: Einige der über 6500 bekannten Arten der Thysanoptera sind wirtschaftlich relevante Schädlinge verschiedener Kulturpflanzen. Aufgrund immer häufigerer Resistenzbildungen ist das grundlegende Wissen über diese Arten von besonderer Bedeutung, um neue Bekämpfungsmethoden zu finden. Um dieses Wissen zu erweitern, wurde in dieser Arbeit verschiedene Methoden zur quantitativen und qualitativen Applikation von Nährlösungen und Substanzen an einzelne und Gruppen von Thripse entwickelt. Hauptsächlich wurde dabei die Art Frankliniella occidentalis verwendet. Anhand dieser Art konnte zum ersten Mal die komplette Entwicklung, von der frisch geschlüpften Erstlarve bis zum adulten Tier, bei ausschließlicher, regelmäßiger Verabreichung einer künstlichen Nährlösung gezeigt werden. Die Ergebnisse der Arbeit könnten hierbei ein Startpunkt für neue Projekte in Grundlagenforschungen mit neuen Bekämpfungsmethoden für verschiedene Thysanoptera-Arten sein.
description: Some of the more than 6500 known species of Thysanoptera are economically relevant pests of various crops. Due to more and more frequent development of resistance, the basic knowledge about these species is of particular importance in order to find new pest control methods. In order to increase this knowledge, different methods for quantitative and qualitative application of nutrient solutions and substances to individual and groups of thrips were developed. Mainly the species Frankliniella occidentalis was used. We could show for the first time with exclusive, regular administration of an artificial nutrient solution the complete development, from the freshly hatched first larva to the adult animal. The results of this work here could be a starting point for new projects in basic research with new control methods for different Thysanoptera species.
A risk assessment infrastructure for powered wheelchair motion commands without full sensor coverage
Creators: name: TalebiFard, Pouria
Publisher: name: University of British Columbia
Year: 2014

description: Smart powered wheelchairs offer the possibility of enhanced mobility to a large and growing population---most notably older adults---and a key feature of such a chair is collision avoidance. Sensors are required to detect nearby obstacles; however, complete sensor coverage of the immediate neighbourhood is challenging for reasons including financial, computational, aesthetic, user identity and sensor reliability. It is also desirable to predict the future motion of the wheelchair based on potential input signals; however, direct modeling and control of commercial wheelchairs is not possible because of proprietary internals and interfaces. In this thesis we design a dynamic egocentric occupancy map which maintains information about local obstacles even when they are outside the field of view of the sensor system, and we construct a neural network model of the mapping between joystick inputs and wheelchair motion. Using this map and model infrastructure, we can evaluate a variety of risk assessment metrics for collaborative control of a smart wheelchair. One such metric is demonstrated on a wheelchair with a single RGB-D camera in a doorway traversal scenario where the near edge of the doorframe is no longer visible to the camera as the chair makes its turn.
From Constitutional Pyramid to Constitutional Pluralism: The Transformation of the European Constitutional Imaginary in Context
Creators: name: Canihac, Hugo
Publisher: name: Zenodo
Year: 2020

description: This paper explores the recent history of the European constitutional imaginary. It argues that the constitutional imaginary that solidified during the early decades of European integration has been deeply challenged in the 1990s, with the emergence of a body of thought known as ‘constitutional pluralism’. In order to do so, the paper first reconstructs the original constitutional imaginary of the EEC. It then analyses the socio-historical context of the emergence of constitutional pluralism, on the one hand, and clarifies how these ideas contributed to redefining the European constitutional imaginary, on the other.
Potential Theory for Directed Networks
Creators: name: Zhang, Qian-Ming
name: Lü, Linyuan
name: Wang, Wen-Qiang
name: Zhu, Yu-Xiao
name: Zhou, Tao
Publisher: name: arXiv
Year: 2012
Subjects: subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: Information Retrieval (cs.IR)
subject: Social and Information Networks (cs.SI)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Uncovering factors underlying the network formation is a long-standing challenge for data mining and network analysis. In particular, the microscopic organizing principles of directed networks are less understood than those of undirected networks. This article proposes a hypothesis named potential theory, which assumes that every directed link corresponds to a decrease of a unit potential and subgraphs with definable potential values for all nodes are preferred. Combining the potential theory with the clustering and homophily mechanisms, it is deduced that the Bi-fan structure consisting of 4 nodes and 4 directed links is the most favored local structure in directed networks. Our hypothesis receives strongly positive supports from extensive experiments on 15 directed networks drawn from disparate fields, as indicated by the most accurate and robust performance of Bi-fan predictor within the link prediction framework. In summary, our main contribution is twofold: (i) We propose a new mechanism for the local organization of directed networks; (ii) We design the corresponding link prediction algorithm, which can not only testify our hypothesis, but also find out direct applications in missing link prediction and friendship recommendation.
description: 8 pages, 6 figures
Accessing novel activities and selectivities of haem-dependent enzymes by high-throughput methodologies [Kumulative Dissertation]
Creators: name: Knorrscheidt, Anja
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 540

description: Die gerichtete Evolution, als Laborstrategie, ahmt die natürliche Evolution durch iterative Zyklen genetischer Diversifizierung kombiniert mit einem Bibliotheks-Screening/Selektion nach, um so Enzyme mit einer gewünschten katalytischen Funktion zu entwickeln. In dieser Arbeit wurden zwei Häm-abhängige Enzymklassen als Katalysatoren für anspruchsvolle C‒H-Funktionalisierungen eingesetzt. Das durchgeführte Protein Engineering erforderte die Entwicklung und Anwendung von Hochdurchsatztechniken, die zur Identifizierung von verbesserten Enzymvarianten führten. Dadurch wurden mittels des E. coli Proteins YfeX Tryptaminderivate zugänglich gemacht. Im weiteren ermöglichten Enzymvarianten der unspezifischen Peroxygenase aus Myceliophthora thermophila (MthUPO) den Zugang zu verbesserten Chemo- und Regioselektivitäten von benzylischen, aromatischen und terminalen Oxidationen, um so das Selektivitätsproblem dieser Enzymklasse zu bewältigen.
description: Directed evolution, as a laboratory strategy, mimics the natural evolution by iterative rounds of genetic diversification and library screening or selection to evolve enzymes towards a desired catalytic function. In this thesis, two haem-dependent enzyme classes were utilised as catalysts for challenging C‒H functionalisations. The implemented protein engineering required the development and application of high-throughput techniques, which resulted in the identification of enhanced enzyme variants. Thereby, the E. coli protein YfeX enabled the access to tryptamine derivatives. In addition, enzyme variants of the unspecific peroxygenase from Myceliophthora thermophila (MthUPO) exhibited enhanced chemo- and regioselectivities of benzylic, aromatic and terminal oxidations addressing the selectivity problem of this enzyme class.
Uniqueness of weighted Sobolev spaces with weakly differentiable weights
Creators: name: Tölle, Jonas M.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Functional Analysis (math.FA)
subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 46E35, 35J92, 35K65

description: We prove that weakly differentiable weights $w$ which, together with their reciprocals, satisfy certain local integrability conditions, admit a unique associated first-order $p$-Sobolev space, that is \[H^{1,p}(\mathbb{R}^d,w\,\d x)=V^{1,p}(\mathbb{R}^d,w\,\d x)=W^{1,p}(\mathbb{R}^d,w\,\d x),\] where $d\in\N$ and $p\in [1,\infty)$. If $w$ admits a (weak) logarithmic gradient $\nabla w/w$ which is in $L^q_{\text{loc}}(w\,\d x;\R^d)$, $q=p/(p-1)$, we propose an alternative definition of the weighted $p$-Sobolev space based on an integration by parts formula involving $\nabla w/w$. We prove that weights of the form $\exp(-β|\cdot|^q-W-V)$ are $p$-admissible, in particular, satisfy a Poincaré inequality, where $β\in (0,\infty)$, $W$, $V$ are convex and bounded below such that $|\nabla W|$ satisfies a growth condition (depending on $β$ and $q$) and $V$ is bounded. We apply the uniqueness result to weights of this type. The associated nonlinear degenerate evolution equation is also discussed.
description: 23 pp., to appear in J. Funct. Anal. (in press)
The covariance of multi-field perturbations, pseudo-susy and f_NL
Creators: name: Saffin, Paul M.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We reconsider cosmological perturbation theory for multi-component scalars, enforcing covariance in field-space, and ensuring that phyical observations are independent of field re-definitions. We use the formalism to clarify some issues in the literature, and use pseudo-supersymmetry to derive exact expressions for terms of interest.
description: 22 pages, 2 figures. Replaced with Journal version
Gelfand models for classical Weyl groups
Creators: name: Araujo, José O.
name: Bratten, Tim
Publisher: name: arXiv
Year: 2011
Subjects: subject: Representation Theory (math.RT)
subject: FOS: Mathematics

description: In a recent preprint Kodiyalam and Verma give a particularly simple Gelfand model for the symmetric group that is built naturally on the space of involutions. In this manuscript we give a natural extension of Kodiyalam and Verma's model to a Gelfand model for Weyl groups of type B_{n} and D_{2n+1}. Then we define an explicit isomorphism between this Gelfand model and the polynomial model using a technique that we call telescopic decomposition.
description: The final revised version to appear in Journal of Algebra
When Scholarship Matters: Theory-Building and Theory Effects in the EU Polity Context
Creators: name: Vauchez, Antoine
Publisher: name: Zenodo
Year: 2020

description: I welcome Jan Komárek’s project to engage in a history of “European Constitutional Imaginaries” as seen through EU law landmark theories and most prominent authors. Some malicious minds would think of it as yet another avatar of the “scholastic bias” that structurally incites us scholars to transform our professional anxieties (what is my/our scholarship worth for?) into full-fledged research question (do ideas matter?)… Others could see it as a vain exercise in nostalgia, as EU law researchers return to a golden age, that of the late 1980s, in which EU law was indeed able to frame professional identities and capture political imaginaries way beyond the academic circles. I would rather take it as part of the “critical turn” that has come along the sense of désoeuvrement so pervasive among EU lawyers ever since the constitutional project failed to gather popular support. A détour to the history of the discipline can indeed be a powerful methodological device to strengthen our reflexive gaze and, maybe, start again rolling up the immense boulder of theoretically connecting Europe, the European Union and the Law. I would argue however that the success of such endeavor is conditioned by our capacity to provide a renewed analytical framework able to compare past theoretical undertakings not only from an “internal” point of view (in terms of legal ideas) but also from an “external” point of view (in terms of social and political relevance) and -most importantly- account for the tensions and contradictions between the two. I take the very notions of “utopia”, “imaginaries” and “ideology” introduced by the project IMAGINE, that all refer to the capacity of legal ideas to capture political expectations and strategies, as strong incentives to move in that direction. In this paper, I suggest to examine theories of European law along two (partly conflicting) dimensions -their scientific robustness and their social relevance- and apply this simple conceptual toolbox to three historical constellations of European law theory.
Knottedness is in NP, modulo GRH
Creators: name: Kuperberg, Greg
Publisher: name: arXiv
Year: 2011
Subjects: subject: Geometric Topology (math.GT)
subject: Computational Complexity (cs.CC)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences

description: Given a tame knot K presented in the form of a knot diagram, we show that the problem of determining whether K is knotted is in the complexity class NP, assuming the generalized Riemann hypothesis (GRH). In other words, there exists a polynomial-length certificate that can be verified in polynomial time to prove that K is non-trivial. GRH is not needed to believe the certificate, but only to find a short certificate. This result complements the result of Hass, Lagarias, and Pippenger that unknottedness is in NP. Our proof is a corollary of major results of others in algebraic geometry and geometric topology.
description: 7 pages; minor update
Dimensionsbestimmung der interossären Region des Sakroiliakalgelenks für ein neues Implantatsystem
Creators: name: Leicht, Jakob
Publisher: name: Otto-von-Guericke-Universität Magdeburg
Year: 2021
Subjects: subject: Iliosakralgelenk
subject: Spiral-CT
subject: 612.752

description: Ziel der Untersuchung ist die Vermessung der interossären Region des Sakroiliakalgelenks für ein geplantes Implantatsystem zur Behandlung des sakroiliakalen Schmerzsyndroms unter Erhaltung der normalen Beweglichkeit. Angelehnt an die komplexe Anatomie wurde ein neues Verfahren zur CT-gestützten Vermessung entwickelt. Insgesamt zeigt sich eine deutliche Streuung der Messwerte. Das superiore Kompartiment der interossären Region ist am größten und regelmäßigsten ausgeprägt und kommt daher am ehesten für eine Implantation in Frage. Auffällig ist auch ein Geschlechtsdimorphismus, der die bekannten Geschlechtsunterschiede des Beckenskeletts widerspiegelt. Zusammenhänge der Dimensionen mit dem Alter, der spinalen sagittalen Balance oder dem Grad der Arthrose konnten nicht festgestellt werden. Basierend auf den Ergebnissen werden Vorschläge für einen Prototyp des geplanten Implantats gemacht.
The Failure to Grapple with Racial Capitalism in European Constitutionalism
Creators: name: Miller, Jeffrey
name: Nicola, Fernanda
Publisher: name: Zenodo
Year: 2020

description: Since the 1980s prominent scholars of European legal integration have used the example of U.S. constitutionalism to promote a federal vision for the European Community. These scholars, drawing lessons from developments across the Atlantic, concluded that the U.S. Supreme Court had played a key role in fostering national integration and market liberalization. They foresaw the possibility for the European Court of Justice (ECJ) to be a catalyst for a similar federal and constitutional outcome in Europe. The present contribution argues that the scholars who constructed today’s dominant European constitutional paradigm underemphasized key aspects of the U.S. constitutional experience, including judgments that favored states’ rights doctrines that buttressed the social plagues of slavery and laissez faire policies that reinforced economic inequality. This selective reception of the U.S. experience, bracketing racial subordination and neoliberal policies under the rubric of states’ rights, propelled European constitutionalism into a neverland—one that claimed to draw inspiration from U.S. constitutionalism, while simultaneously dismissing as irrelevant some of its most profound socio-economic challenges. This is important, we argue, because the dominant European constitutional paradigm not only provides a distorted picture of U.S. constitutionalism, but also inhibits a deeper understanding of the European one due to its inability to grapple with racial capitalism, embedded both in its colonial past and its present ECJ antidiscrimination jurisprudence.
Helix shuffling in staphylococcal protein A : design, selection and characterization of novel domain B variants
Creators: name: Bobolowski, Hanna
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 572

description: Protein A domain B is an IgG-binding surface protein localized in the cell wall of Staphylococcus aureus. In the presented work, recombinant domain B variants were generated by helix shuffling. Variants obtained by rational design and directed evolution show a domain B-like function and structure. The analyzed variants exhibit an affinity for the Fc region of human antibodies of KD = 10-6-10-8 M. The α-helical secondary structure of the variants is comparable to wild type B, whereas the thermal stability of these proteins is significantly reduced (Tm ~31 °C). One selected domain B variant was used as affinity ligand for the purification of human antibodies. Interestingly, a milder elution (pH 4.8) of antibodies was detected for the alternative domain B compared to wild type B (pH 3.7).
description: Protein A Domäne B ist ein IgG-bindendes Oberflächenprotein, welches in der Zellwand von Staphylococcus aureus lokalisiert ist. In der vorliegenden Arbeit wurden rekombinante Domäne B Varianten mittels Helix Shuffling generiert. Die durch rationales Design und gerichtete Evolution erzeugten Varianten sind funktionell und strukturell ähnlich zu Wildtyp B. Die analysierten Varianten besitzen eine Affinität für die Fc-Region humaner Antikörper von KD = 10-6-10-8 M. Die α-helikale Sekundärstruktur der Varianten ist vergleichbar zu Wildtyp B, wohingegen die thermische Stabilität dieser Proteine deutlich reduziert ist (Tm ~31 °C). Eine ausgewählte Domäne B Variante wurde als Affinitätsligand für die Reinigung von humanen Antikörpern verwendet. Interessanterweise wurde für die alternative Domäne B eine mildere Elution (pH 4,8) der Antikörper im Vergleich zu Wildtyp B (pH 3,7) detektiert.
Encoding a qubit with Majorana modes in superconducting circuits
Creators: name: You, J. Q.
name: Wang, Z. D.
name: Zhang, Wenxian
name: Nori, Franco
Publisher: name: arXiv
Year: 2011
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Majorana fermions are long-sought exotic particles that are their own antiparticles. Here we propose to utilize superconducting circuits to construct two superconducting-qubit arrays where Majorana modes can occur. A so-called Majorana qubit is encoded by using the unpaired Majorana modes, which emerge at the left and right ends of the chain in the Majorana-fermion representation. We also show this Majorana qubit in the spin representation and its advantage, over a single superconducting qubit, regarding quantum coherence. Moreover, we propose to use four superconducting qubits as the smallest system to demonstrate the braiding of Majorana modes and show how the states before and after braiding Majoranas can be discriminated.
description: 10 pages, 3 figures; an enlarged version of arXiv: 1108.3712v1
On the complexity of solving linear congruences and computing nullspaces modulo a constant
Creators: name: de Beaudrap, Niel
Publisher: name: arXiv
Year: 2012
Subjects: subject: Computational Complexity (cs.CC)
subject: FOS: Computer and information sciences
subject: F.1.3; F.2.1
subject: 11D04, 68Q25

description: We consider the problems of determining the feasibility of a linear congruence, producing a solution to a linear congruence, and finding a spanning set for the nullspace of an integer matrix, where each problem is considered modulo an arbitrary constant k>1. These problems are known to be complete for the logspace modular counting classes {Mod_k L} = {coMod_k L} in special case that k is prime (Buntrock et al, 1992). By considering variants of standard logspace function classes --- related to #L and functions computable by UL machines, but which only characterize the number of accepting paths modulo k --- we show that these problems of linear algebra are also complete for {coMod_k L} for any constant k>1. Our results are obtained by defining a class of functions FUL_k which are low for {Mod_k L} and {coMod_k L} for k>1, using ideas similar to those used in the case of k prime in (Buntrock et al, 1992) to show closure of Mod_k L under NC^1 reductions (including {Mod_k L} oracle reductions). In addition to the results above, we briefly consider the relationship of the class FUL_k for arbitrary moduli k to the class {F.coMod_k L} of functions whose output symbols are verifiable by {coMod_k L} algorithms; and consider what consequences such a comparison may have for oracle closure results of the form {Mod_k L}^{Mod_k L} = {Mod_k L} for composite k.
description: 17 pages, one Appendix; minor corrections and revisions to presentation, new observations regarding the prospect of oracle closures. Comments welcome
Fabrication of out-of-plane microneedles for drug delivery and biosensing
Creators: name: Mansoor, Iman
Publisher: name: University of British Columbia
Year: 2014

description: Hollow microneedles can be used to painlessly inject drugs or extract dermal interstitial fluid for biosensing. However, their fabrication so far has been associated with costly and time-consuming steps restricting their batch production as a viable option. This thesis presents novel methods for fabricating inexpensive hollow microneedles, and investigates new methods of characterizing the drug delivery and interstitial fluid sampling using microneedles. First, a method is presented for fabrication of hollow polymer microneedle arrays. Microneedles are formed during a solvent casting process, which leaves a polymer layer around pillars in a pre-fabricated mold. Arrays of microneedles with lengths up to 250 µm have been fabricated. The strength of the microneedles was evaluated to ensure reliable skin penetration and their suitability for drug delivery was demonstrated by injection of fluorescent beads into a skin sample. A second fabrication method is presented for making metallic microneedles with high aspect ratios. Solvent casting was used to coat a mold with a conductive polymer composite layer, which was then used as a seed layer in a metal electrodeposition process to form 500 µm tall microneedles. Some fabrication process steps were characterized and the strength of the microneedles was evaluated. Their usefulness for drug delivery was also demonstrated by injection of fluorescent microspheres into animal skin. Designing effective microneedles requires understanding the drug diffusion process in skin. Here, a novel method is used to characterize diffusion of a chemotherapeutic drug injected with microneedles into skin. Using confocal microscopy, the concentration distribution of the drug was measured over time and then compared to an analytical diffusion model to obtain the drug’s diffusion coefficient. Using this method, different skin storage conditions were evaluated. It was concluded that using previously frozen skin should be avoided for transdermal drug delivery studies. Finally, using the proposed processes, hollow and solid microneedles were fabricated for sampling interstitial fluid for biosensing applications. Minimal removal of the interstitial fluid was achieved with a solid microneedle design as well as a hollow metallic microneedle array attached to a vacuum probe, while no trace of the fluid was observed when using hollow polymer microneedles.
The Janson inequalities for general up-sets
Creators: name: Riordan, Oliver
name: Warnke, Lutz
Publisher: name: arXiv
Year: 2012
Subjects: subject: Probability (math.PR)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 60F10 (Primary), 60C05, 05C80 (Secondary)

description: Janson and Janson, Luczak and Rucinski proved several inequalities for the lower tail of the distribution of the number of events that hold, when all the events are up-sets (increasing events) of a special form - each event is the intersection of some subset of a single set of independent events (i.e., a principal up-set). We show that these inequalities in fact hold for arbitrary up-sets, by modifying existing proofs to use only positive correlation, avoiding the need to assume positive correlation conditioned on one of the events.
description: 5 pages. Added weighted variant
Well-posedness and spectral properties of heat and wave equations with non-local conditions
Creators: name: Mugnolo, Delio
name: Nicaise, Serge
Publisher: name: arXiv
Year: 2011
Subjects: subject: Analysis of PDEs (math.AP)
subject: Mathematical Physics (math-ph)
subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 47D06, 35J20, 34B10

description: We consider the one-dimensional heat and wave equations but -- instead of boundary conditions-- we impose on the solution certain non-local, integral constraints. An appropriate Hilbert setting leads to an integration-by-parts formula in Sobolev spaces of negative order and eventually allows us to use semigroup theory leading to analytic well-posedness, hence sharpening regularity results previously obtained by other authors. In doing so we introduce a parametrization of such integral conditions that includes known cases but also shows the connection with more usual boundary conditions, like periodic ones. In the self-adjoint case, we even obtain eigenvalue asymptotics of so-called Weyl's type.
description: 23 pages
European Constitutional Imaginaries: On Pluralism, Calculemus, Imperium and Communitas
Creators: name: Přibáň, Jiří
Publisher: name: Zenodo
Year: 2021

description: This chapter draws on the theory of societal constitutionalism to analyse polysemy and polyvalence of the European constitutional imaginaries. It argues that European constitutional imaginaries have to be distinguished from the imagination of EU constitutional theory as much as European political ideologies and utopias. They spontaneously evolve in European society and, despite their theoretical contextualisations and uses, cannot be purposively constructed by theorists to justify integration and constitutionalisation of Europe. Imaginaries are societal power which precedes structures of political power and constitutes the common understanding of social reality despite all its fragmentations, diffusions and differentiations. The chapter thus highlights the sociological meaning of the concept of imaginary as background power of both national and transnational legal and political systems which determines legitimacies and illegitimacies in EU law and politics. It subsequently analyses specific imaginaries of EU integration and their general components. It concludes by arguing that these European constitutional imaginaries are part of societal constitutionalism of the EU beyond constraints of law and politics and the old semantics driven by the imaginary unity of statehood.
GaAs optoelectronic integrated circuits for gigabit ethernet
Creators: name: Cheskis, D.
name: Huang, C.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 1999
Subjects: ING-INF/01 Elettronica

description: The ability to integrate MSM photodiodes on the same chips with trans impedance preamplifiers differentiates Gallium Arsenide (GaAs) from Silicon for Gigabit Ethernet applications. It also signals one of the first practical applications of optoelectronic integrated circuits (OEICs). In this talk, we'll review the explosive Gigabit Ethernet market and the various GaAs IC's and OEICs that are poised to serve the market.
Sequestration of infected red blood cells and reduced venous efflux precede excessive inflammatory responses in experimental cerebral malaria
Creators: name: Bhattacharjee, Rituparna
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: Parasitologie
subject: Immunologie
subject: Malaria
subject: red blood cells
subject: 570

description: Cerebral malaria (CM) is a complex neurological complication of severe malaria caused by Plasmodium falciparum. Sequestration of infected red blood cells to the brain vasculature and excessive inflammatory responses in the brain are the key features of CM pathogenesis. Recent imaging studies have established edema development with rise in intracranial pressure as an indicator of fatal CM outcome. However, the link between sequestration of infected red blood cells, excessive inflammation and edema development remains elusive till date. In the present study, in vivo neuroimaging techniques, SPECT/CT and MRI, followed by immunohistochemistry stainings and quantitative reverse transcription-PCR measurements were performed on the mouse model of experimental cerebral malaria (ECM) investigating the rapid progression of the disease starting from an early stage. Sequestration of infected red blood cells, especially in the regions of large draining veins, was observed as the primary event of ECM pathogenesis, present already at a neurologically asymptomatic stage. Reduction of cerebral venous efflux and impaired perfusion in the territories of large draining veins and sinuses ensued, also from the early stage, which worsened with disease progression. In comparison, activation of astrocytes, microglia, endothelial cells and accumulation of leukocytes like CD8+ T cells were observed mostly at a later stage in the neurologically sick mice. Simultaneously, a pro-inflammatory storm of cytokines and chemokines could be detected at this late phase of ECM. Also, a disturbance in rostral migratory stream was observed, from an early stage, which could lead to an impairment in neurogenesis. Severe bilateral edema developed in the white matter tracts of the fatally sick mice. Collectively, the present study suggests direct effect of infected RBC sequestration on the spatiotemporal patterns of edema development by venous efflux reduction while excessive inflammation appears at a later stage
GaAs custom MMIC foundry service : a business view
Creators: name: Rocchi, Marc
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 1999
Subjects: ING-INF/01 Elettronica

description: In the 80's, almost all the GaAs IC companies offered on a commercial basis to fabricate prototype MMIC's designed or not by the customer himself into the foundry proprietary processes. Most of the leading GaAs IC companies have today discontinued their foundry service to focus on large volume production of standard parts like power amplifiers for mobilecom terminals. However the traditional custom foundry business is well alive and kicking and will reach 250 MEuros in 2000 representing 20 % of the total GaAs MMIC market. It is no longer limited to prototyping but also includes small to medium volume production of customer specific ICs (CSICs). The various GaAs custom foundry services are reviewed in detail including process guarantees, CAD support and   the "known good die"  issue. The economics of a GaAs foundry service is revisited and a business perspective for the coming years is given.
Charakterisierung von Perizyten und ihren Mikrovesikeln in einem Modell für zerebrale Mikroangiopathie
Creators: name: Morenz, Martin
Publisher: name: Otto-von-Guericke-Universität Magdeburg
Year: 2021
Subjects: subject: Perizyt
subject: Mikroangiopathie
subject: Hirngefäß
subject: 573.862139

description: Perizyten sind perivaskuläre Zellen, die engen Kontakt zu den kleinsten Gefäßen aller Organe haben. An Gehirngefäßen sind sie besonders hoch konzentriert und haben eine essentielle Funktion in der Aufrechterhaltung der schützenden Bluthirnschranke sowie eine zentrale Stellung im neuartigen Konzept der neurovaskulären Einheit. Die zerebrale Mikroangiopathie ist die Ursache eines großen Anteils aller Schlaganfälle, ist aber pathophysiologisch nicht vollständig verstanden und verbleibt ohne bewährte Therapieansätze. In dieser Arbeit wurden 6 und 25 Wochen alte SHRSP, ein Rattenmodell für zerebrale Mikroangiopathie, per primärer Perizytenzellkultur und direkter Untersuchung der Gehirne und Seren mit Kontrollratten verglichen. Es wird eine Reduktion in der Genexpression von Perizytenmarkern sowie in der Produktion von Mikrovesikeln, einer Art kommunikativer extrazellulärer Vesikel, in der SHRSP-Kultur festgestellt. Mikrovesikel der SHRSP-Perizyten haben im Gegensatz zu denen der Kontrollgruppe keinen proliferatorischen Effekt in einem Wundheilungs-Assay. Analyse der Gehirne zeigt eine Reduktion von Perizytenmarkern und Tight-Junction-Proteinen in den alten SHRSP-Ratten. Erhöhte Zytokinkonzentrationen im Serum der SHRSP-Ratten sprechen für eine systemische Entzündungskomponente. Insgesamt suggerieren diese Daten, dass Perizyten eine wichtige Rolle in der Pathophysiologie der zerebralen Mikroangiopathie spielen, und einen potentiellen therapeutischen Angriffspunkt darstellen könnten.
A review of flip-chip GaAs circuits, models, interconnections and modelling techniques in use at Marconi
Creators: name: Davies, I.
name: Phillips, W.A.
name: Humpston, G.
name: Niman, M.J.
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 1999
Subjects: ING-INF/01 Elettronica

description: Broadband high frequency systems are increasingly utilising MMIC technology to reduce circuit design uncertainties. At frequencies above 6 GHz the MMIC interconnections become critical, bond wire inductances become significant and bond length variations in the assembly process cause significant performance variation. At Marconi Electronic Systems the benefits of solder bump connections to the MMIC are being explored. These benefits include very low inductance, self-alignment and repeatable connections. The technology is also extremely well suited to automatic and semi-automatic production, making multiple channel systems such as phased arrays more cost-effective. This paper is a review of recent work (2-40 GHz) on solder bumped MMIC circuits and covers broadband flip-chip S-parameter circuit interconnect modelling, thermal modelling of HEMT transistors connected by solder bump arrays. Additional layers to the MMT H40 Foundry process have been specially designed to facilitate solder bump connection.
Der Einfluss kindlicher Traumatisierung auf die funktionelle Konnektivität im Resting-State
Creators: name: Födisch, Carina
Publisher: name: Otto-von-Guericke-Universität Magdeburg
Year: 2021
Subjects: subject: Psychisches Trauma
subject: Kind
subject: Hirnfunktion
subject: Pädophilie
subject: 616.858

description: Traumata in der Kindheit stellen einen Risikofaktor für die Entwicklung psychischer Erkrankungen von gesunden und Menschen mit abweichender Sexualpräferenz im Erwachsenenalter dar. Laut bisheriger Studienlage sind mit der Amygdala und dem medialen Präfrontalkortex Gehirnkorrelate von Traumata bekannt. In der vorliegenden Arbeit wurde der Einfluss kindlicher Traumatisierung auf die funktionelle Konnektivität im Ruhezustand im 3 und 7 Tesla fMRT bei gesunden und pädophilen Probanden bzw. Sexualstraftätern ohne pädophile Sexualpräferenz untersucht. Es konnte ein Einfluss unterschiedlicher Arten von Traumata auf die Amygdala und den dorsalen anterioren cingulären Kortex, Regionen des limbischen und Salienz-Netzwerkes, auf den medialen bzw. lateralen Präfrontalkortex, Regionen des Default-Mode- Netzwerkes und des zentralen exekutiven Netzwerkes, sowie auf frontale, temporale, parietale und okzipitale Regionen detektiert werden. Dabei wurde bei gesunden Probanden ein Einfluss von Traumata sowohl auf der Amygdala-Gesamtebene im 3 Tesla fMRT als auch auf Amygdalakern-Ebene im 7 Tesla fMRT beobachtet. Somit konnten mit der Amygdala und Regionen des Default-Mode-Netzwerkes Gehirnkorrelate von Traumata bei gesunden und Menschen mit abweichender Sexualpräferenz festgestellt werden, welche sich jedoch in der Art des Traumaeinflusses, der Lateralisierung der Amygdala sowie der spezifischen Seed- Region stark unterschieden. Es kann davon ausgegangen werden, dass die Amygadala eine erhöhte Vulnerabilität durch kindliche Traumata aufweist und durch Verbindungen zu Arealen, wie dem Präfrontalkortex, zu einer beeinträchtigten Emotionsverarbeitung und -regulation sowie der Entwicklung emotionaler Probleme führen kann. Mit diesen Ergebnissen kann die Entwicklung geeigneter Instrumente zur Intervention und Behandlung traumatisierter Kinder und Jugendlicher gefördert und die Entwicklung internalisierender Störungen früher erkannt werden.