cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
An energy-absorbing sliding seat for reducing neck injury risks in rear impact—analysis for prototype built
Creators: name: Zhang, Xiaowei
name: Zhou, Qing
Publisher: name: Taylor & Francis
Year: 2016
Subjects: Medicine
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Science Policy

description: Objective: This study investigated overall performance of an energy-absorbing sliding seat concept for whiplash neck injury prevention. The sliding seat allows its seat pan to slide backward for some distance under certain restraint force to absorb crash energy in rear impacts. Methods: A numerical model that consisted of vehicle interior, seat, seat belt, and BioRID II dummy was built in MADYMO to evaluate whiplash neck injury in rear impact. A parametric study of the effects of sliding seat parameters, including position and cushion stiffness of head restraint, seatback cushion stiffness, recliner characteristics, and especially sliding energy-absorbing (EA) restraint force, on neck injury criteria was conducted in order to compare the effectiveness of the sliding seat concept with that of other existing anti-whiplash mechanisms. Optimal sliding seat design configurations in rear crashes of different severities were obtained. A sliding seat prototype with bending of a steel strip as an EA mechanism was fabricated and tested in a sled test environment to validate the concept. The performance of the sliding seat under frontal and rollover impacts was checked to make sure the sliding mechanism did not result in any negative effects. Results: The protective effect of the sliding seat with EA restraint force is comparable to that of head restraint–based and recliner stiffness–based anti-whiplash mechanisms. EA restraint force levels of 3 kN in rear impacts of low and medium severities and 6 kN in impacts of high severity were obtained from optimization. In frontal collision and rollover, compared to the nonsliding seat, the sliding seat does not result in any negative effects on occupant protection. The sled test results of the sliding seat prototype have shown the effectiveness of the concept for reducing neck injury risks. Conclusion: As a countermeasure, the sliding seat with appropriate restraint forces can significantly reduce whiplash neck injury risk in rear impacts of low, medium, and high severities with no negative effects on other crash load cases.
An energy-absorbing sliding seat for reducing neck injury risks in rear impact – Analysis for prototype built
Creators: name: Zhang, Xiaowei
name: Zhou, Qing
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences
subject: Medicine

description: Objective: This study investigated overall performance of an energy-absorbing sliding seat concept for whiplash neck injury prevention. The sliding seat allows its seat pan to slide backward for some distance under certain restraint force to absorb crash energy in rear impacts.
Methods: A numerical model that consisted of vehicle interior, seat, seatbelt and BioRID II dummy was built in MADYMO to evaluate whiplash neck injury in rear impact. A parametric study of the effects of sliding seat parameters, including position and cushion stiffness of head restraint, seatback cushion stiffness, recliner characteristics and especially, sliding energy-absorbing (EA) restraint force, on neck injury criteria was conducted in order to compare the effectiveness of the sliding seat concept with that of other existing anti-whiplash mechanisms. Optimal sliding-seat-design configurations in rear crashes of different severities were obtained. A sliding seat prototype with bending of a steel strip as EA mechanism was fabricated and tested in sled test environment to validate the concept. Performances of the sliding seat under frontal and rollover impacts were checked to make sure the sliding mechanism did not bring any negative effects.
Results: The protection effect of the sliding seat with EA restraint force is comparable with that of head restraint-based and recliner stiffness-based anti-whiplash mechanisms. EA restraint force levels of 3 kN in rear impacts of low and medium severities and 6 kN in high severity were obtained from optimization. In frontal collision and rollover, compared to non-sliding seat, the sliding seat does not bring any negative effects on occupant protection. The sled test results of the sliding seat prototype have shown the effectiveness of the concept for reducing neck injury risks.
Conclusion: As a countermeasure, the sliding seat with appropriate restraint forces can significantly reduce whiplash neck injury risk in rear impacts of low, medium and high severities with no negative effects on other crash load cases.
Simultaneous Densitometric Analysis of Amlodipine, Hydrochlorothiazide, Lisinopril and Valsartan by HPTLC in Pharmaceutical Formulations and Human Plasma
Creators: name: Jui J. Pandya
name: Sanyal, Mallika
name: Pranav S. Shrivastav
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: A simple, accurate and precise high-performance thin layer chromatographic (HPTLC) method has been developed and validated for the simultaneous quantification of antihypertensive drugs, amlodipine (AML), hydrochlorothiazide (HCTZ), lisinopril (LIS) and valsartan (VAL) in their pharmaceutical formulations and human plasma. Separation of the drugs was performed on aluminium-backed layer of silica gel 60 F254 using a mixture of methanol-dichloromethane-glacial acetic acid (9.0:1.0:0.1, v/v/v) as the mobile phase. Densitometric determination of the separated spots was done at 215 nm. The retention factors (Rf) obtained under the optimized conditions were 0.56, 0.75, 0.29 and 0.67 for AML, HCTZ, LIS and VAL respectively. Linearity of the method was established in the range of 200-1500 ng/band for AML, 300-1500 ng/band for HCTZ, 400-2000 ng/band for LIS and 1000-7000 ng/band for VAL. The LOD/LOQ of the method found were 54.21/164.28, 77.27/234.15, 83.45/252.87 and 156.48/474.19 ng/band for AML, HCTZ, LIS and VAL respectively. To determine the drugs in spiked plasma samples, solid phase extraction was performed, which provided highly consistent and quantitative recovery for all four drugs. The method was satisfactorily applied for the analysis of different tablet formulations and proved to be specific and accurate for the quality control of these drugs.
Jacobian Spillovers in Environmental Technological Proximity: The Role of Mahalanobis Index on European Patents within the Triad
Creators: name: Kotsemir, Maxim
name: Aldieri, Luigi
name: Vinci, Concetto Paolo
Publisher: name: figshare
Year: 2017
Subjects: subject: 130103 Higher Education
subject: FOS: Educational sciences
subject: 50205 Environmental Management
subject: FOS: Earth and related environmental sciences
subject: 50206 Environmental Monitoring
subject: 160507 Environment Policy
subject: FOS: Political science
subject: 160605 Environmental Politics
subject: Environmental Science
subject: 90703 Environmental Technologies
subject: FOS: Environmental engineering
subject: 140205 Environment and Resource Economics
subject: FOS: Economics and business
subject: 90799 Environmental Engineering not elsewhere classified
subject: 59999 Environmental Sciences not elsewhere classified
subject: 50299 Environmental Science and Management not elsewhere classified

description: Available at SSRN: https://ssrn.com/abstract=2931340

The aim of this paper is to investigate the role of Jacobian externalities stemmed from different technological sectors for international firms engaged both in environmental and in dirty activities. Firms’ innovation, measured, as the development of new patents, is a key factor behind the achievement of desired economic performances. Empirical literature usually deals with the integration between ecological efficiency and product value enhancement. The results of these studies lead to the lack of integrated innovation adoption behind environmental productivity performance.

In this work, we analyse the integration between more environmental goals in an original way, by applying different methodologies to compute technological proximity, based on the Mahalanobis approach. To this end, we use information from 240 large international firms, located in three economic areas: USA, Japan and Europe and we select their environmental and dirty patents from European Patent Office data.

Available at SSRN: https://ssrn.com/abstract=2931340
Paleolimnology of the Lake of the Woods southern basin: continued water quality degradation despite lower nutrient influx
Creators: name: Reavie, Euan D.
name: Edlund, Mark B.
name: Andresen, Norman A.
name: Engstrom, Daniel R.
name: Leavitt, Peter R.
name: Schottler, Shawn
name: Meijun Cai
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Reavie ED, Edlund MB, Andresen NA, Engstrom DR, Leavitt PR, Schottler S, Cai M. 2017. Paleolimnology of the Lake of the Woods southern basin: continued water quality degradation despite lower nutrient influx. Lake Reserv Manage. 33:369–385. Despite decades of reduced nutrient inputs, Lake of the Woods, a large, shallow boreal lake on the US-Canadian border, shows little evidence of water quality improvements in the pelagic system. Here we analyzed sediments from 6 sites in the southern basin for diverse biogeochemical (loss-on-ignition, biogenic silica, pigments) and microfossil (diatoms, chrysophytes) remains to reconstruct the environmental history of the lake. Our objectives were to quantify the magnitude and direction of historical trophic change and evaluate reasons for an apparent lack of basin recovery following documented nutrient diversion. Evidence came from fossil indicator profiles and comparisons of these long-term trends with historical land use and monitoring data. Results indicate major changes in algal communities during and following peak nutrient loading in the mid-20th century as well as more recent increases in colonial cyanobacteria and high-nutrient diatom taxa. Combined, fossil indicators reflect an anthropogenically enriched system that has undergone substantial ecological change, particularly since ∼1980, due to multiple drivers. Physical changes in lake thermal regime resulting from climate warming may be exacerbating internal phosphorus release from sediments, thereby lowering nitrogen:phosphorus ratios and enhancing cyanobacterial abundance. These drivers of lake condition in the lake may apply to other large shallow lakes that exhibit only limited biological recovery from reduced external nutrient loading.
Testing Hypotheses of Covariate-Adaptive Randomized Clinical Trials
Creators: name: Ma, Wei
name: Hu, Feifang
name: Zhang, Lixin
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Infectious Diseases
subject: FOS: Health sciences
subject: Science Policy
subject: Cancer
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Genetics

description: Covariate-adaptive designs are often implemented to balance important covariates in clinical trials. However, the theoretical properties of conventional testing hypotheses are usually unknown under covariate-adaptive randomized clinical trials. In the literature, most studies are based on simulations. In this article, we provide theoretical foundation of hypothesis testing under covariate-adaptive designs based on linear models. We derive the asymptotic distributions of the test statistics of testing both treatment effects and the significance of covariates under null and alternative hypotheses. Under a large class of covariate-adaptive designs, (i) the hypothesis testing to compare treatment effects is usually conservative in terms of small Type I error; (ii) the hypothesis testing to compare treatment effects is usually more powerful than complete randomization; and (iii) the hypothesis testing for significance of covariates is still valid. The class includes most of the covariate-adaptive designs in the literature; for example, Pocock and Simon’s marginal procedure, stratified permuted block design, etc. Numerical studies are also performed to assess their corresponding finite sample properties. Supplementary material for this article is available online.
"L'histoire en cuisine" pour le site internet d'ARTE, 2005.
Creators: name: Duhart, Frédéric
Publisher: name: Zenodo
Year: 2005
Subjects: History of Food; Cuisine; Europe; Cookbooks

description: Les cinq textes que voici furent rédigés à la demande de la chaîne de télévision européenne ARTE pour être mis en ligne sur son site internet au moment de la première diffusion de la série documentaire L'histoire en cuisine (Michèle Barrière / Philippe Allante, BM Production) en octobre 2005. Ils demeurèrent longtemps accessibles par ce lien, aujourd'hui désactivé : http://www.arte-tv.com/fr/connaissance-decouverte/L_27histoire_20en_20cuisine/2000_20ans_20d_27histoire_20en_20cuisine/975390.html.
 Leur thématique fut dictée par celle des épisodes de la série télévisuelle:
 Cuisines antiques, Cuisines médiévales, Cuisines de la Renaissance, Cuisines des Lumières et Cuisines de l'ère des révolutions. Chaque texte évoque des aspects majeurs de la cuisine d'une époque. Contient une bibliographie d'orientation pour chaque période.
Surgery Scheduling with Recovery Resources
Creators: name: Bam, Maya
name: Denton, Brian T.
name: Oyen, Mark P. Van
name: Cowen, Mark E.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Surgical services are large revenue sources that account for a large portion of hospital expenses. Thus, efficient resource allocation is crucial in this system; however, this is a challenging problem in part due to the interaction of the different stages of the surgery delivery system, and the uncertainty of surgery and recovery durations. This article focuses on single-day inpatient elective surgery scheduling considering surgeons, operating rooms (ORs), and the post-anesthesia care unit (recovery). We propose a mixed integer programming formulation of this problem and then present a fast 2-phase heuristic: phase 1 is used for determining the number of ORs to open for the day and surgeon-to-OR assignments, and phase 2 is used for surgical case sequencing. Both phases have provable worst-case performance guarantees and excellent average case performance. We evaluate schedules under uncertainty using a discrete event simulation model based on data provided by a mid-sized hospital. We show that the fast and easy-to-implement 2-phase heuristic performs extremely well, both in the deterministic and stochastic settings. The new methods developed reduce the computational barriers to implementation and demonstrate that hospitals can realize substantial benefits without resorting to sophisticated optimization software implementations.
Paleolimnology of the Lake of the Woods southern basin: Continued water quality degradation despite lower nutrient influx
Creators: name: Reavie, Euan D.
name: Edlund, Mark B.
name: Andresen, Norman A.
name: Engstrom, Daniel R.
name: Leavitt, Peter R.
name: Schottler, Shawn
name: Meijun Cai
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Reavie ED, Edlund MB, Andresen NA, Engstrom DR, Leavitt PR, Schottler S, Cai M. 2017. Paleolimnology of the Lake of the Woods southern basin: Continued water quality degradation despite lower nutrient influx. Lake Reserv Manage. 00:00–00. Despite decades of reduced nutrient inputs, Lake of the Woods, a large, shallow boreal lake on the US-Canadian border, shows little evidence of water quality improvements in the pelagic system. Here we analyzed sediments from 6 sites in the southern basin for diverse biogeochemical (loss-on-ignition, biogenic silica, pigments) and microfossil (diatoms, chrysophytes) remains to reconstruct the environmental history of the lake. Our objectives were to quantify the magnitude and direction of historical trophic change and evaluate reasons for an apparent lack of basin recovery following documented nutrient diversion. Evidence came from fossil indicator profiles and comparisons of these long-term trends with historical land use and monitoring data. Results indicate major changes in algal communities during and following peak nutrient loading in the mid-20th century as well as more recent increases in colonial cyanobacteria and high-nutrient diatom taxa. Combined, fossil indicators reflect an anthropogenically enriched system that has undergone substantial ecological change, particularly since ∼1980, due to multiple drivers. Physical changes in lake thermal regime resulting from climate warming may be exacerbating internal phosphorus release from sediments, thereby lowering nitrogen:phosphorus ratios and enhancing cyanobacterial abundance. These drivers of lake condition in the lake may apply to other large shallow lakes that exhibit only limited biological recovery from reduced external nutrient loading.
Effective density and volatility of particles sampled from a helicopter gas turbine engine
Creators: name: Olfert, Jason S.
name: Dickau, Matthew
name: Momenimovahed, Ali
name: Meghdad Saffaripour
name: Thomson, Kevin
name: Smallwood, Greg
name: Stettler, Marc E. J.
name: Boies, Adam
name: Sevcenco, Yura
name: Crayford, Andrew
name: Johnson, Mark
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology

description: The effective density and size-resolved volatility of particles emitted from a Rolls-Royce Gnome helicopter turboshaft engine are measured at two engine speed settings (13,000 and 22,000 RPM). The effective density of denuded and undenuded particles was measured. The denuded effective densities are similar to the effective densities of particles from a gas turbine with a double annular combustor as well as a wide variety of internal combustion engines. The denuded effective density measurements were also used to estimate the size and number of primary particles in the soot aggregates. The primary particle size estimates show that the primary particle size was smaller at lower engine speed (in agreement with transmission electron microscopy analysis). As a demonstration, the size-resolved volatility of particles emitted from the engine is measured with a system consisting of a differential mobility analyzer, centrifugal particle mass analyzer, condensation particle counter, and catalytic stripper. This system determines the number distributions of particles that contain or do not contain non-volatile material, and the mass distributions of non-volatile material, volatile material condensed onto the surface of non-volatile particles, and volatile material forming independent particles (e.g., nucleated volatile material). It was found that the particulate at 13,000 RPM contained a measurable fraction of purely volatile material with diameters below ∼25 nm and had a higher mass fraction of volatile material condensed on the surface of the soot (6%–12%) compared to the 22,000 RPM condition (1%–5%). This study demonstrates the potential to quantify the distribution of volatile particulate matter and gives additional information to characterize sampling effects with regulatory measurement procedures. Copyright © 2017 American Association for Aerosol Research
Novel agar–stearyl alcohol oleogel-based bigels as structured delivery vehicles
Creators: name: Kodela, Sarika Patel
name: Pandey, Preeti Madhuri
name: Nayak, Suraj K.
name: K. Uvanesh
name: Arfat Anis
name: Kunal Pal
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Computational Biology

description: The present study describes the synthesis of novel bigels as delivery matrices for controlled delivery applications. The bigels were prepared by mixing agar hydrogel and stearyl alcohol oleogel in different proportions. The microscopic analysis of the bigels suggested the formation of biphasic bigels at lower proportions of oleogel and bicontinuous bigel at higher proportions. Stress relaxation study was used to analyze the mechanical properties. The viscoelastic property of the bigels was estimated by modeling the relaxation profile using Weichert model of viscoelasticity. The analysis of the electrical property of the bigels showed an increase in the impedance values as the oleogel content was increased. Further, a corresponding decrease in the electrical stability of the bigels was observed with an increase in the oleogel proportion. The analysis was prepared using (RQ)Q equivalent electrical circuit model. The ciprofloxacin hydrochloride release from the bigels was predominantly diffusion-mediated as analyzed by Korsmeyer–Pappas and Peppas–Sahlin models.
Other
Creators: name: Castledine, Meaghan
name: Ramoneda, Josep
name: Jones, Matt Lloyd
name: Lear, Luke
Publisher: name: OSF Registries
Year: 2021

description: Start date: March 2021

Anticipated completion date: September 2021

Stage of review at time of submission: Preliminary searches (Completed), Piloting (Started), Abstract screening (Started).

Funding sources/sponsors:
This research is funded by a Discretionary Funds Project from EAWAG Aquatic Research DF20 / 5221.00492.113.04

Conflicts of interest: None

Language: English

Country: Switzerland, England

Details of any existing review of the same topic by the same authors: None

Current review status: Ongoing

Bibliography:

Bell, T., Lilley, A.K., Hector, A., Schmid, B., King, L. and Newman, J.A., 2009. A linear model method for biodiversity–ecosystem functioning experiments. The American Naturalist, 174(6), 836-849.

Moran, N. P., Sánchez‐Tójar, A., Schielzeth, H., & Reinhold, K. (2020). Poor nutritional condition promotes high-risk behaviours: A systematic review and meta-analysis. Biological Reviews, n/a(n/a). https://doi.org/10.1111/brv.12655

Nakagawa, S., & Santos, E. S. A. (2012). Methodological issues and advances in biological meta-analysis. Evolutionary Ecology, 26(5), 1253–1274. https://doi.org/10.1007/s10682-012-9555-5

Nakagawa, S., & Schielzeth, H. (2013). A general and simple method for obtaining R2 from generalized linear mixed-effects models. Methods in Ecology and Evolution, 4(2), 133–142. https://doi.org/10.1111/j.2041-210x.2012.00261.x

Pustejovsky, J. E. (2018). Using response ratios for meta-analyzing single-case designs with behavioral outcomes. Journal of School Psychology, 68, 99–112. https://doi.org/10.1016/j.jsp.2018.02.003

Pustejovsky, J. E., & Swan, D. M. (2019). SingleCaseES: A Calculator for Single-Case Effect Sizes. https://CRAN.R-project.org/package=SingleCaseES

Sánchez-Tójar, A., Nakagawa, S., Sánchez-Fortún, M., Martin, D. A., Ramani, S., Girndt, A., Bókony, V., Kempenaers, B., Liker, A., Westneat, D. F., Burke, T., & Schroeder, J. (2018). Meta-analysis challenges a textbook example of status signalling and demonstrates publication bias. eLife, 7, e37385. https://doi.org/10.7554/eLife.37385

Viechtbauer, W. (2010). Conducting Meta-Analyses in R with the metafor Package. Journal of Statistical Software, 36(3). https://doi.org/10.18637/jss.v036.i03
LADE-Based Inference for ARMA Models With Unspecified and Heavy-Tailed Heteroscedastic Noises
Creators: name: Zhu, Ke
name: Ling, Shiqing
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Earth and Environmental Sciences
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences

description: This article develops a systematic procedure of statistical inference for the auto-regressive moving average (ARMA) model with unspecified and heavy-tailed heteroscedastic noises. We first investigate the least absolute deviation estimator (LADE) and the self-weighted LADE for the model. Both estimators are shown to be strongly consistent and asymptotically normal when the noise has a finite variance and infinite variance, respectively. The rates of convergence of the LADE and the self-weighted LADE are n− 1/2, which is faster than those of least-square estimator (LSE) for the ARMA model when the tail index of generalized auto-regressive conditional heteroskedasticity (GARCH) noises is in (0, 4], and thus they are more efficient in this case. Since their asymptotic covariance matrices cannot be estimated directly from the sample, we develop the random weighting approach for statistical inference under this nonstandard case. We further propose a novel sign-based portmanteau test for model adequacy. Simulation study is carried out to assess the performance of our procedure and one real illustrating example is given. Supplementary materials for this article are available online.
Adrenal pathology: Elements of biologic models and practical applications
Creators: name: Diaz-Cano, Salvador J.
Publisher: name: figshare
Year: 2017
Subjects: subject: 111202 Cancer Diagnosis
subject: FOS: Clinical medicine
subject: 111203 Cancer Genetics
subject: 110306 Endocrinology
subject: 110199 Medical Biochemistry and Metabolomics not elsewhere classified
subject: 110104 Medical Biochemistry: Lipids
subject: 111201 Cancer Cell Biology
subject: Pathogenesis
subject: 110316 Pathology (excl. Oral Pathology)

description: The natural history of adrenal lesions depends on the understanding of the main biological features, which have different application criteria in both cortical and medullary proliferation. Those vital elements represent the cornerstone for proper pathologic diagnosis. They include: Adrenal cortical lesions: - Malignancy criteria - Contributions of gene expression - Cellular heterogeneity - Cell segregation and vascular supply - Morphology and function Adrenal medullary lesions: - Pheochromocytomas in familial syndromes - Precursor lesions: Criteria, clonality, and kinetic - Malignancy and topographic heterogeneity
Polarity in GaN and ZnO: Theory, measurement, growth, and devices
Creators: name: Zúñiga-Pérez, Jesús
name: Consonni, Vincent
name: Lymperakis, Liverios
name: Kong, Xiang
name: Trampert, Achim
name: Fernández-Garrido, Sergio
name: Brandt, Oliver
name: Renevier, Hubert
name: Keller, Stacia
name: Hestroffer, Karine
name: Wagner, Markus R.
name: Juan Sebastián, Reparaz
name: Akyol, Fatih
name: Rajan, Siddharth
name: Rennesson, Stéphanie
name: Palacios, Tomás
name: Feuillet, Guy
Publisher: name: Technische Universität Berlin
Year: 2016
Subjects: subject: 530 Physik
subject: gallium nitride
subject: zinc oxide
subject: polarity
subject: GaN
subject: ZnO
subject: polarization

description: This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Appl. Phys. Rev. 3, 041303 (2016) and may be found at https://doi.org/10.1063/1.4963919.
description: The polar nature of the wurtzite crystalline structure of GaN and ZnO results in the existence of a spontaneous electric polarization within these materials and their associated alloys (Ga,Al,In)N and (Zn,Mg,Cd)O. The polarity has also important consequences on the stability of the different crystallographic surfaces, and this becomes especially important when considering epitaxial growth. Furthermore, the internal polarization fields may adversely affect the properties of optoelectronic devices but is also used as a potential advantage for advanced electronic devices. In this article, polarity-related issues in GaN and ZnO are reviewed, going from theoretical considerations to electronic and optoelectronic devices, through thin film, and nanostructure growth. The necessary theoretical background is first introduced and the stability of the cation and anion polarity surfaces is discussed. For assessing the polarity, one has to make use of specific characterization methods, which are described in detail. Subsequently, the nucleation and growth mechanisms of thin films and nanostructures, including nanowires, are presented, reviewing the specific growth conditions that allow controlling the polarity of such objects. Eventually, the demonstrated and/or expected effects of polarity on the properties and performances of optoelectronic and electronic devices are reported. The present review is intended to yield an in-depth view of some of the hot topics related to polarity in GaN and ZnO, a fast growing subject over the last decade.
The Impact of Research Collaboration on Academic Performance: An Empirical Analysis for Russian Universities
Creators: name: Kotsemir, Maxim
name: Vinci, Concetto Paolo
name: Aldieri, Luigi
Publisher: name: figshare
Year: 2017
Subjects: subject: 130103 Higher Education
subject: FOS: Educational sciences
subject: Library and Information Studies
subject: FOS: Media and communications
subject: 160511 Research, Science and Technology Policy
subject: FOS: Political science

description: Available at SSRN: https://ssrn.com/abstract=2913517
The aim of this paper is to investigate the impact of external research collaborations on the scientific performance of academic institutions. Data are derived from the international SCOPUS database. We consider the number of citations of publications to evaluate university performance in Russia. To this end, we develop a non-overlapping generations model to evidence the theoretical idea of research externalities between academic institutions. Moreover, we implement different empirical models to test for the effect of external scientific collaborations on the institutional research quality. The results confirm an important positive impact of co-authoring process.

Available at SSRN: https://ssrn.com/abstract=2913517
Dysplasia and epithelial polyps in gastrointestinal tract
Creators: name: Diaz-Cano, Salvador J.
Publisher: name: figshare
Year: 2017
Subjects: subject: Biomarkers
subject: 111201 Cancer Cell Biology
subject: FOS: Clinical medicine
subject: 111202 Cancer Diagnosis
subject: 111203 Cancer Genetics
subject: Diseases
subject: 110307 Gastroenterology and Hepatology
subject: Pathogenesis
subject: 110316 Pathology (excl. Oral Pathology)

description: Dysplastic lesions, preceding invasive colonic neoplasm can present as flat or elevated lesions, are relevant due to: - High incidence in daily practice - It is an evolving area with diagnostic criteria frequently modified that result in low reproducibility - It is a critical area for prevention and screening of CRC The main controversial areas are: - In the context of inflammatory bowel disease, and - Grading, subtyping, and staging of polyps
Inflammatory dermatopathology in general medicine: Case review
Creators: name: Diaz-Cano, Salvador J.
Publisher: name: figshare
Year: 2017
Subjects: subject: 110704 Cellular Immunology
subject: FOS: Clinical medicine
subject: 110304 Dermatology
subject: Diseases
subject: 110799 Immunology not elsewhere classified
subject: Pathogenesis
subject: 110316 Pathology (excl. Oral Pathology)

description: Selected cases of inflammatory skin lesions in the context of general medicine are presented and discussed under the scope of pattern recognition and its main differential diagnosis. The main topic areas include hypertrophic lichenoid lesions, vasculitis, panniculitis, hyperkeratosis, nodular/granulomatous lesions, vesicular lesions, and fibrosing lesions.
Exploration of the chlorpyrifos escape pathway from acylpeptide hydrolases using steered molecular dynamics simulations
Creators: name: Wang, Dongmei
name: Jin, Hanyong
name: Wang, Junling
name: Guan, Shanshan
name: Zhang, Zuoming
name: Han, Weiwei
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biochemistry
Neuroscience
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified

description: Acylpeptide hydrolases (APH) catalyze the removal of an N-acylated amino acid from blocked peptides. APH is significantly more sensitive than acetylcholinesterase, a target of Alzheimer’s disease, to inhibition by organophosphorus (OP) compounds. Thus, OP compounds can be used as a tool to probe the physiological functions of APH. Here, we report the results of a computational study of molecular dynamics simulations of APH bound to the OP compounds and an exploration of the chlorpyrifos escape pathway using steered molecular dynamics (SMD) simulations. In addition, we apply SMD simulations to identify potential escape routes of chlorpyrifos from hydrolase hydrophobic cavities in the APH-inhibitor complex. Two previously proposed APH pathways were reliably identified by CAVER 3.0, with the estimated relative importance of P1 > P2 for its size. We identify the major pathway, P2, using SMD simulations, and Arg526, Glu88, Gly86, and Asn65 are identified as important residues for the ligand leaving via P2. These results may help in the design of APH-targeting drugs with improved efficacy, as well as in understanding APH selectivity of the inhibitor binding in the prolyl oligopeptidase family.
New phenyl derivatives from endophytic fungus Botryosphaeria sp. SCSIO KcF6 derived of mangrove plant Kandelia candel
Creators: name: Ju, Zhi-ran
name: Qin, Xiaochu
name: Lin, Xiu-Ping
name: Wang, Jun-Feng
name: Kaliyaperumal, Kumaravel
name: Tian, Yong-qi
name: Liu, Juan
name: Liu, Fen
name: Tu, Zhengchao
name: Xu, Shi-Hai
name: Liu, Yonghong
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Pharmacology
subject: Biochemistry

description: Two new phenyl derivatives (1 and 3), along with two new natural products (4 and 5), and three known compounds (2, 6 and 7), were isolated from an endophytic fungus Botryosphaeria sp. SCSIO KcF6. The structures of these compounds 1–7 were elucidated by the extensive 1D and 2D-NMR and HRESIMS Data analysis, and compared with those of reported data. The absolute configuration of the compounds 1 and 3 were assigned by optical rotation and CD data. The isolated compounds were evaluated for their cytotoxic, anti-inflammatory (COX-2) and antimicrobial activities. Compound 3 exhibited a specific COX-2 inhibitory activity with the IC50 value of 1.12 μM.
MPRA_paper_76408.pdf
Creators: name: Kotsemir, Maxim
name: Vinci, Concetto Paolo
name: Aldieri, Luigi
Publisher: name: figshare
Year: 2017
Subjects: subject: 130103 Higher Education
subject: FOS: Educational sciences

description: Available at SSRN: https://ssrn.com/abstract=2913517
The aim of this paper is to investigate the impact of external research collaborations on the scientific performance of academic institutions. Data are derived from the international SCOPUS database. We consider the number of citations of publications to evaluate university performance in Russia. To this end, we develop a non-overlapping generations model to evidence the theoretical idea of research externalities between academic institutions. Moreover, we implement different empirical models to test for the effect of external scientific collaborations on the institutional research quality. The results confirm an important positive impact of co-authoring process.

Available at SSRN: https://ssrn.com/abstract=2913517
Patterns and mechanisms of inflammatory skin conditions: the pathologist’s survival kit
Creators: name: Diaz-Cano, Salvador J.
Publisher: name: figshare
Year: 2017
Subjects: subject: 110304 Dermatology
subject: FOS: Clinical medicine
subject: 110799 Immunology not elsewhere classified
subject: 110707 Innate Immunity
subject: Pathogenesis
subject: 110316 Pathology (excl. Oral Pathology)

description: The diagnostic approach for inflammatory skin conditions depends primarily on pattern recognition, which is the result of the damaging agent, the tissue reparative response, the time and intensity of the lesion. For this analysis, it is essential: - Cellular response (cell perpetuation pathway, cell differentiation pathway, and activation of “default” cell death pathway) - Tissue effects (parenchymal and stromal interactions) - The combination of findings depending on the primary damage target The patterns are the result of the interaction of injury agents and tissue response, modulated in intensity and time - Elementary lesions will depend on: * primary epidermal reaction (based on cellular turnover and maturation), vascular and cellular inflammatory components, * types of cells, and * distribution of cells (topography and microanatomy) - The activity should be evaluated a from target damage (epithelial necrosis, vasculitis), exocytosis (neutrophilic), and density of infiltrate - Morphological and clinicopathologic correlation should be included in the conclusion
Diagnosis, biology, and meaning of melanocytic dysplasia
Creators: name: Diaz-Cano, Salvador J.
Publisher: name: figshare
Year: 2017
Subjects: subject: 111201 Cancer Cell Biology
subject: FOS: Clinical medicine
subject: 111202 Cancer Diagnosis
subject: 111203 Cancer Genetics
subject: 110304 Dermatology
subject: Pathogenesis
subject: 110316 Pathology (excl. Oral Pathology)

description: Melanocytic dysplasia is a controversial concept, initially applied to recognized melanoma precursor lesions. However, there is no real consensus on its application, types, pathologic conditions, differential diagnosis, and its natural history. The primary aspects covered in this paper include: - Concept and criteria. Grading - Pathologic conditions and main types (epithelioid and lentiginous) - Differential diagnosis (Atypia and regenerative changes, and Inflammation and regression) - Progressive or regressive nature of melanocytic dysplasia
Two new dammarane-type triterpene sapogenins from Chinese red ginseng
Creators: name: Zheng, Qian
name: Li, Zhuo
name: Liu, Jinping
name: Han, Liu
name: Zhang, Hao
name: Li, Pingya
name: Zhang, Nanqi
name: Chen, Jinluan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: Two new dammarane-type triterpene sapogenins were isolated from the Chinese red ginseng. The new sapogenins were named as 24,26-dihydroxy-panaxdiol (1) and 24-hydroxy-panaxdiol (2). Their structures were elucidated by the combined analysis of NMR and mass spectrometry as 20(S),25(R)-epoxydammarane-3β,12β,24β,26-tetraol (1) and 20(S),25-epoxydammarane-3β,12β,24α-triol (2). The complete signal assignments of the two compounds were carried out by 2D NMR spectral and NOE differential spectroscopy analysis.
Multi-residue analysis of pesticides in traditional Chinese medicines using gas chromatography-negative chemical ionisation tandem mass spectrometry
Creators: name: Nie, Jing
name: Miao, Shui
name: Lehotay, Steven J.
name: Li, Wen-Ting
name: Zhou, Heng
name: Mao, Xiu-Hong
name: Lu, Ji-Wei
name: Lan, Lan
name: Ji, Shen
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Chemistry
subject: Pharmacology
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: In this study, a residue analysis method for the simultaneous determination of 107 pesticides in traditional Chinese medicines (TCMs), Angelica sinensis, A. dahurica, Leonurus heterophyllus Sweet, Pogostemon cablin and Lonicera japonica Thunb., was developed using gas chromatography coupled with tandem mass spectrometry in negative chemical ionisation mode (GC-NCI-MS/MS). NCI has advantages of high sensitivity and selectivity to chemicals with electron-withdrawing groups, and yields low background interference. For sample preparation, QuEChERS (quick, easy, cheap, effective, rugged and safe) was applied. Due to the unique characteristics of TCMs, the clean-up step was optimised by adjusting amounts of primary secondary amine, C18, graphitised carbon black and silica sorbents. Validation was mainly performed by determining analyte recoveries at four different spiking concentrations of 10, 50, 100 and 200 ng g−1, with seven replicates at each concentration. Method trueness, precision, linearity of calibration curves, lowest calibrated levels (LCLs) and matrix effects were determined to demonstrate method and instrument performance. Among the 107 pesticides tested, approximately 80% gave recoveries from 80% to 110% and < 10% relative standard deviation (RSD). The LCLs for nearly all pesticides were 5 ng g−1, and as low as 0.1 ng g−1 for dichlofenthion, endosulfan sulphate, flumetralin, isofenphos-methyl, methyl-pentachlorophenyl sulphide and trifluralin. The results indicate that GC-NCI-MS/MS is an excellent technique for quantitative and qualitative analysis of targeted GC-amenable pesticides at ultra-trace levels, especially in complex matrices such as TCMs.
ROBOTIZING SOLAR FARMS IN VIETNAM - AN OPTIMAL SOLUTION TO REDUCE MAINTENANCE COST AND INCREASE EFFICIENCY
Creators: name: Bharath K, Shakthi
name: Rangaraju, Surender
name: Isaac, Osama
name: Ghosh, , Abhijit
name: Vo, Phu Le
Publisher: name: figshare
Year: 2022
Subjects: subject: 90608 Renewable Power and Energy Systems Engineering (excl. Solar Cells)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Vietnam is a country emerging in solar energy as Asia races to fight climate change, the country ranks seventh in the world in terms of installed solar capacity. The country gives a tremendous push towards renewable power to fit its growing demand for power to fuel economic growth with long coastline with consistent high radiation levels for solar. Due to the change in climatic conditions in Vietnam the efficiency of the solar panel will reduce and maintaining the panels over large capacity is difficult. Robots can play a significant role in maintenance of photovoltaics. As the country’s future economy based on renewable power several action by human activities can be greatly reduced. Robot installation in PV industry helps in lowering production cost in solar cell, effective cleaning and ensure the sustainability of solar cell. Robots and Automation magnifies the power production in solar farms and tends to provide a constant efficiency in solar cells achieving country’s energy demand.
A bioactive cycloartane triterpene from Garcinia hombroniana
Creators: name: Jamila, Nargis
name: Khan, Naeem
name: Khan, Imran
name: Atlas Khan, Amir
name: Noor Khan, Sadiq
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Plant Biology
subject: FOS: Biological sciences

description: The dichloromethane bark extract of Garcinia hombroniana yielded one new cycloartane triterpene; (22Z,24E)-3β-hydroxycycloart-14,22,24-trien-26-oic acid (1) together with five known compounds: garcihombronane G (2), garcihombronane J (3), 3β acetoxy-9α-hydroxy-17,14-friedolanostan-14,24-dien-26-oic acid (4), (22Z, 24E)-3β, 9α-dihydroxy-17,14-friedolanostan-14,22,24-trien-26-oic acid (5) and 3β, 23α-dihydroxy-17,14-friedolanostan-8,14,24-trien-26-oic acid (6). Their structures were established by the spectral techniques of NMR and ESI-MS. These compounds together with some previously isolated compounds; garcihombronane B (7), garcihombronane D (8) 2,3’,4,5’-tetrahydroxy-6-methoxybenzophenone (9), volkensiflavone (10), 4’’-O-methyll-volkensiflavone (11), volkensiflavone-7-O-glucopyranoside (12), volkensiflavone-7-O-rhamnopyranoside (13), Morelloflavone (14), 3’’-O-methyl-morelloflavone (15) and morelloflavone-7-O-glucopyranoside (16) were evaluated for cholinesterase enzymes inhibitory activities using acetylcholinesterase and butyrylcholinesterase. In these activities, compounds 1–9 showed good dual inhibition on both the enzymes while compounds 10–16 did not reasonably contribute to both the cholinesterases inhibitory effects.
Two new glycosides isolated from Sapindus mukorossi fruits: effects on cell apoptosis and caspase-3 activation in human lung carcinoma cells
Creators: name: Zhang, Xuan-Ming
name: Yang, De-Po
name: Xie, Zhi-Yong
name: Li, Qing
name: Zhu, Long-Ping
name: Zhao, Zhi-Min
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Virology

description: Two new glycosides (1, 2) and two saponins (3, 4) were isolated from the fruits of Sapindus mukorossi Gaertn. The two glycosides were designated as sapindoside G (1) and 4′′,4′′′′′-O-diacetylmukurozioside IIa (2). All four compounds exhibited inhibitory effects against A549 human lung adenocarcinoma cells with inhibition rates up to 69.2–83.3% at a concentration of 100 μg/mL. Flow cytometric analysis revealed that compounds 1–4 could suppress A549 cell growth by promoting cell apoptosis, which was related to the activation of caspase-3.