The Gene Ontology knowledgebase in 2023.
Creators: name: Consortium, Gene Ontology
name: Aleksander, Suzi A
name: Balhoff, James
name: Carbon, Seth
name: Cherry, J Michael
name: Drabkin, Harold J
name: Ebert, Dustin
name: Feuermann, Marc
name: Gaudet, Pascale
name: Harris, Nomi L
name: Hill, David P
name: Lee, Raymond
name: Mi, Huaiyu
name: Moxon, Sierra
name: Mungall, Christopher J
name: Muruganugan, Anushya
name: Mushayahama, Tremayne
name: Sternberg, Paul W
name: Thomas, Paul D
name: Van Auken, Kimberly
name: Ramsey, Jolene
name: Siegele, Deborah A
name: Chisholm, Rex L
name: Fey, Petra
name: Aspromonte, Maria Cristina
name: Nugnes, Maria Victoria
name: Quaglia, Federica
name: Tosatto, Silvio
name: Giglio, Michelle
name: Nadendla, Suvarna
name: Antonazzo, Giulia
name: Attrill, Helen
name: Dos Santos, Gil
name: Marygold, Steven
name: Strelets, Victor
name: Tabone, Christopher J
name: Thurmond, Jim
name: Zhou, Pinglei
name: Ahmed, Saadullah H
name: Asanitthong, Praoparn
name: Buitrago, Diana Luna
name: Erdol, Meltem N
name: Gage, Matthew C
name: Kadhum, Mohamed Ali
name: Li, Kan Yan Chloe
name: Long, Miao
name: Michalak, Aleksandra
name: Pesala, Angeline
name: Pritazahra, Armalya
name: Saverimuttu, Shirin CC
name: Su, Renzhi
name: Thurlow, Kate E
name: Lovering, Ruth C
name: Logie, Colin
name: Oliferenko, Snezhana
name: Blake, Judith
name: Christie, Karen
name: Corbani, Lori
name: Dolan, Mary E
name: Ni, Li
name: Sitnikov, Dmitry
name: Smith, Cynthia
name: Cuzick, Alayne
name: Seager, James
name: Cooper, Laurel
name: Elser, Justin
name: Jaiswal, Pankaj
name: Gupta, Parul
name: Naithani, Sushma
name: Lera-Ramirez, Manuel
name: Rutherford, Kim
name: Wood, Valerie
name: De Pons, Jeffrey L
name: Dwinell, Melinda R
name: Hayman, G Thomas
name: Kaldunski, Mary L
name: Kwitek, Anne E
name: Laulederkind, Stanley JF
name: Tutaj, Marek A
name: Vedi, Mahima
name: Wang, Shur-Jen
name: D'Eustachio, Peter
name: Aimo, Lucila
name: Axelsen, Kristian
name: Bridge, Alan
name: Hyka-Nouspikel, Nevila
name: Morgat, Anne
name: Engel, Stacia R
name: Karra, Kalpana
name: Miyasato, Stuart R
name: Nash, Robert S
name: Skrzypek, Marek S
name: Weng, Shuai
name: Wong, Edith D
name: Bakker, Erika
name: Berardini, Tanya Z
name: Reiser, Leonore
name: Auchincloss, Andrea
name: Argoud-Puy, Ghislaine
name: Blatter, Marie-Claude
name: Boutet, Emmanuel
name: Breuza, Lionel
name: Casals-Casas, Cristina
name: Coudert, Elisabeth
name: Estreicher, Anne
name: Famiglietti, Maria Livia
name: Gos, Arnaud
name: Gruaz-Gumowski, Nadine
name: Hulo, Chantal
name: Jungo, Florence
name: Le Mercier, Philippe
name: Lieberherr, Damien
name: Masson, Patrick
name: Pedruzzi, Ivo
name: Pourcel, Lucille
name: Poux, Sylvain
name: Rivoire, Catherine
name: Sundaram, Shyamala
name: Bateman, Alex
name: Bowler-Barnett, Emily
name: Bye-A-Jee, Hema
name: Denny, Paul
name: Ignatchenko, Alexandr
name: Ishtiaq, Rizwan
name: Lock, Antonia
name: Lussi, Yvonne
name: Magrane, Michele
name: Martin, Maria J
name: Orchard, Sandra
name: Raposo, Pedro
name: Speretta, Elena
name: Tyagi, Nidhi
name: Warner, Kate
name: Zaru, Rossana
name: Diehl, Alexander D
name: Chan, Juancarlos
name: Diamantakis, Stavros
name: Raciti, Daniela
name: Zarowiecki, Magdalena
name: Fisher, Malcolm
name: James-Zorn, Christina
name: Ponferrada, Virgilio
name: Zorn, Aaron
name: Ramachandran, Sridhar
name: Ruzicka, Leyla
name: Westerfield, Monte
Publisher: name: The Francis Crick Institute
Year: 2023
Subjects: Ecology,Evolution &amp; Ethology
Cell Biology
Cell Cycle &amp; Chromosomes

description: The Gene Ontology (GO) knowledgebase (http://geneontology.org) is a comprehensive resource concerning the functions of genes and gene products (proteins and noncoding RNAs). GO annotations cover genes from organisms across the tree of life as well as viruses, though most gene function knowledge currently derives from experiments carried out in a relatively small number of model organisms. Here, we provide an updated overview of the GO knowledgebase, as well as the efforts of the broad, international consortium of scientists that develops, maintains, and updates the GO knowledgebase. The GO knowledgebase consists of three components: (1) the GO-a computational knowledge structure describing the functional characteristics of genes; (2) GO annotations-evidence-supported statements asserting that a specific gene product has a particular functional characteristic; and (3) GO Causal Activity Models (GO-CAMs)-mechanistic models of molecular "pathways" (GO biological processes) created by linking multiple GO annotations using defined relations. Each of these components is continually expanded, revised, and updated in response to newly published discoveries and receives extensive QA checks, reviews, and user feedback. For each of these components, we provide a description of the current contents, recent developments to keep the knowledgebase up to date with new discoveries, and guidance on how users can best make use of the data that we provide. We conclude with future directions for the project.