Program and abstracts of the conference Current Trends in Applied Mass Spectrometry at the KBC Umeå on March 19th and 20th, 2025
Creators: name: Kieselbach, Theresa
Publisher: name: Umeå University
Year: 2025
Subjects: classificationCode: 340105
subject: Instrumental methods (excl. immunological and bioassay methods)
classificationCode: 340106
subject: Metabolomic chemistry
classificationCode: 410599
subject: Pollution and contamination not elsewhere classified
classificationCode: 310205
subject: Proteomics and metabolomics
classificationCode: 460504
subject: Data quality
classificationCode: 460599
subject: Data management and data science not elsewhere classified
classificationCode: 340109
subject: Separation science
classificationCode: 340101
subject: Analytical spectrometry
classificationCode: 340199
subject: Analytical chemistry not elsewhere classified

description: This booklet contains the program and the abstracts of the presentations and the workshops of the conference Current Trends in Applied Mass Spectrometry on March 19<sup>th</sup> and 20<sup>th</sup>, 2025 at the KBC at Umeå University and SLU Umeå. It also gives an account of the organizers, the contributing organizations and companies, and the funding of this conference.This conference is a forum for representatives of industry and researchers in academia to meet one another and to discuss the latest innovations in the field of applied mass spectrometry and possible solutions to analytical problems. It consists of a day with workshops on March 19<sup>th</sup>, 2025, and a day with a conference and a fair on March 20<sup>th</sup>, 2025.The workshops cover selected topics of the workflow of applied mass spectrometry and of the communication of the scientific results. They include an introduction to the Mass Hunter software by Agilent and to sample purification through the electromembrane extraction technology by ETN. In addition, EMBL-EBI, the Swedish Metabolomics Centre (SMC), and Umeå University Library give a hands-on workshop about Open Science and how the MetaboLights repository can help researchers in metabolomics to put it into practice.The conference presentations highlight latest achievements in the technology of LC-MSMS and GC-MS to resolve challenging problems in the identification, structural analysis and quantification of small molecules. Agilent discusses challenges and advancements in the accurate quantification of multiple PFAS compounds at trace levels. Bruker introduces Direct Analysis in Real Time with High Resolution Mass Spectrometry (DART-HRMS) that allows rapid detection and structural analysis of drugs, pesticides and other compound classes in a chromatography-free workflow. Waters presents a novel data-independent and data dependent workflow for metabolite characterization in biotransformation studies using high resolution mass spectrometry.Thermo Fisher Scientific presents the novel Stellar™ MS technology and its capabilities for a fast and sensitive targeted quantification of compounds and the opportunities that it offers in a transition from discovery to clinical practice. Shimadzu introduces and discusses the opportunities of the Oxygen Attachment Dissociation (OAD) technology that specifically breaks C=C bonds and the advantages that it provides for the analysis of lipids.Sciex introduces the advantages of electron activated dissociation (EAD) fragmentation and ZenoTOF technology to create high quality MS2 spectra that allow, for instance, the structural analysis of unknown metabolites and the quantification of lipid isomers. LECO presents an application of two-dimensional gas chromatography coupled with time-of-flight mass spectrometry (GCxGC-TOFMS) to achieve enhanced separation of compounds and high-speed acquisition across the full mass range. In this application, a novel Multi-Mode Source (MMS) was used that can perform EI/CI ionization. This technology provides library-searchable spectra with accurate masses for improved confidence of identification.In summary, this conference offer of a unique opportunity to learn about the latest innovations in Applied Mass Spectrometry and to discuss analytical problems with experts in the field. In addition, it connects Applied Mass Spectrometry and Open Science and offers researchers in metabolomics an opportunity to learn how one can design holistic workflows that can resolve challenging analytical problems and ensure timely scholarly communication.