cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 5 of Drug utilization in patients starting haemodialysis with a focus on cardiovascular and antidiabetic medications: an epidemiological study in the Lazio region (Italy), 2016–2020
Creators: name: Kirchmayer, Ursula
name: Marino, Claudia
name: Feriozzi, Sandro
name: Massimetti, Carlo
name: Manzuoli, Micol
name: Angelici, Laura
name: Bargagli, Anna Maria
name: Cascini, Silvia
name: Addis, Antonio
name: Davoli, Marina
name: Agabiti, Nera
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Marine Biology
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Supplementary Material 5
Why Should a Library Invest in You? or, How to Succeed with Short-Term Library and Archival Fellowship Grants
Creators: name: Margaret Ashton, Susanna
Publisher: name: Humanities Commons
Year: 2013
Subjects: subject: Archives
subject: Academic libraries

description: SHORT-TERM library fellowships are quite likely the single most common kind of national research grant given out to scholars in the humanities. The Massachusetts Historical Society alone gives out twenty short-term library fellowships. Almost every major private university and scholarly library (including the Huntington, Newberry, Yale’s Beinecke, Harvard’s Houghton, and the New-York Historical Society), many public universities (such as the University of Texas, Austin), many major public libraries (such as the Boston Public Library and the New York Public Library), and many small specialized research libraries administrate these types of grants. They are often modest in their monetary amounts (ranging from $1,500 to $4,000) and almost always distributed directly to the individual scholar. They rarely cause much of a blip on the radar of most college and university accounts that track billion-dollar National Science Foundation grants or large institution-sponsored foundation awards such as those from the National Endowment for the Humanities or from the United States Department of State’s Fulbright program. Nonetheless, these modest library grants provide critical footholds for emerging careers. They provide money that isn’t modest to an underpaid assistant professor or struggling graduate student, and they provide critical logistical, emotional, and scholarly support. They usually presume a scholar will be in residence at the institution for any period between two to eight weeks. Their applications tend to be fairly
Additional file 6 of Drug utilization in patients starting haemodialysis with a focus on cardiovascular and antidiabetic medications: an epidemiological study in the Lazio region (Italy), 2016–2020
Creators: name: Kirchmayer, Ursula
name: Marino, Claudia
name: Feriozzi, Sandro
name: Massimetti, Carlo
name: Manzuoli, Micol
name: Angelici, Laura
name: Bargagli, Anna Maria
name: Cascini, Silvia
name: Addis, Antonio
name: Davoli, Marina
name: Agabiti, Nera
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Marine Biology
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Supplementary Material 6
Statistical Learning of Proteomics Data and Global Testing for Data with Correlations
Creators: name: Chen, Donglai
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Applied statistics
Biostatistics
Statistical theory
Statistics not elsewhere classified

description: This dissertation consists of two parts. The first part is a collaborative project with Dr. Szymanski's group in Agronomy at Purdue, to predict protein complex assemblies and interactions. Proteins in the leaf cytosol of Arabidopsis were fractionated using Size Exclusion Chromatography (SEC) and mixed-bed Ion Exchange Chromatography (IEX).Protein mass spectrometry data were obtained for the two platforms of separation and two replicates of each. We combine the four data sets and conduct a series of statistical learning, including 1) data filtering, 2) a two-round hierarchical clustering to integrate multiple data types, 3) validation of clustering based on known protein complexes,4) mining dendrogram trees for prediction of protein complexes. Our method is developed for integrative analysis of different data types and it eliminates the difficulty of choosing an appropriate cluster number in clustering analysis. It provides a statistical learning tool to globally analyze the oligomerization state of a system of protein complexes.

The second part examines global hypothesis testing under sparse alternatives and arbitrarily strong dependence. Global tests are used to aggregate information and reduce the burden of multiple testing. A common situation in modern data analysis is that variables with nonzero effects are sparse. The minimum p-value and higher criticism tests are particularly effective and more powerful than the F test under sparse alternatives. This is the common setting in genome-wide association study (GWAS) data. However, arbitrarily strong dependence among variables poses a great challenge towards the p-value calculation of these optimal tests. We develop a latent variable adjusted method to correct minimum p-value test. After adjustment, test statistics become weakly dependent and the corresponding null distributions are valid. We show that if the latent variable is not related to the response variable, power can be improved. Simulation studies show that our method is more powerful than other methods in highly sparse signal and correlated marginal tests setting. We also show its application in a real dataset.
Safety of dual orexin receptor antagonists: a real-world pharmacovigilance study
Creators: name: Sun, Yu
name: Xu, Tao
name: Xu, Hongbin
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Mental Health

description: Dual orexin receptor antagonists (DORAs) are widely used for treating insomnia. However, real-world data on the adverse events (AEs) induced by DORAs are lacking. Data related to daridorexant, suvorexant, and lemborexant were collected from the US Food and Drug Administration Adverse Event Reporting System between the first quarter of 2022 and the third quarter of 2024. Two established signal quantification methods, the reporting odds ratios and proportional reporting ratios, were applied. A total of 2665 reports on daridorexant (1738, 65.22%), suvorexant (667, 25.03%), and lemborexant (260, 9.75%) were obtained. 24 targeted systems for daridorexant, 24 for suvorexant, and 25 for lemborexant were involved. We analyzed the top 30 preferred terms (PTs) that met both algorithm criteria and identified 69 PTs. The highest signal of strength of PT was sleep paralysis for daridorexant and lemborexant, and abnormal sleep-related event for suvorexant. The most frequent PT was somnolence for lemborexant (30, 11.54%) and insomnia for daridorexant (252, 14.50%) and suvorexant (62, 9.30%) within the top 30 PTs. The analysis of disproportionality signals may prompt increased awareness of toxicities for DORAs. The results of serious reports and dosage of drugs provided supporting evidence for clinicians to manage AEs.
Additional file 7 of Drug utilization in patients starting haemodialysis with a focus on cardiovascular and antidiabetic medications: an epidemiological study in the Lazio region (Italy), 2016–2020
Creators: name: Kirchmayer, Ursula
name: Marino, Claudia
name: Feriozzi, Sandro
name: Massimetti, Carlo
name: Manzuoli, Micol
name: Angelici, Laura
name: Bargagli, Anna Maria
name: Cascini, Silvia
name: Addis, Antonio
name: Davoli, Marina
name: Agabiti, Nera
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Marine Biology
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Supplementary Material 7
Sorbitol-fermenting enterohaemorrhagic Escherichia coli O157:H− causes another outbreak of haemolytic uraemic syndrome in children
Creators: name: Alpers, Katharina
name: Werber, Dirk
name: Frank, Christina
name: Koch, Judith
name: Friedrich, Alexander W.
name: Karch, Helge
name: Heiden, Matthias An Der
name: Prager, Rita
name: Fruth, Angelika
name: Bielaszewska, Martina
name: Morlock, Gabi
name: Heissenhuber, A.
name: Diedler, A.
name: Gerber, A.
name: Ammon, Andrea
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2008
Subjects: subject: Humans
subject: Preschool
subject: Female
subject: Disease Outbreaks
subject: Germany/epidemiology
subject: Male
subject: Child
subject: Case-Control Studies
subject: Food Microbiology
subject: Infant
subject: Logistic Models
subject: Food Contamination
subject: Hemolytic-Uremic Syndrome/microbiology
subject: Hemolytic-Uremic Syndrome/epidemiology
subject: Foodborne Diseases/epidemiology
subject: Escherichia coli O157/isolation & purification
subject: Escherichia coli O157/metabolism
subject: Foodborne Diseases/microbiology
subject: Sorbitol/metabolism
subject: 610 Medizin

description: An outbreak of haemolytic uraemic syndrome (HUS) among children caused by infection with sorbitol-fermenting enterohaemorrhagic Escherichia coli O157:H- (SF EHEC O157:H-) occurred in Germany in 2002. This pathogen has caused several outbreaks so far, yet its reservoir and routes of transmission remain unknown. SF EHEC O157:H- is easily missed as most laboratory protocols target the more common sorbitol non-fermenting strains. We performed active case-finding, extensive exploratory interviews and a case-control study. Clinical and environmental samples were screened for SF EHEC O157:H- and the isolates were subtyped by pulsed-field gel electrophoresis. We identified 38 case-patients in 11 federal states. Four case-patients died during the acute phase (case-fatality ratio 11%). The case-control study could not identify a single vehicle or source. Further studies are necessary to identify the pathogen's reservoir(s). Stool samples of patients with HUS should be tested with an adequate microbiological set-up to quickly identify SF EHEC O157:H-.
Additional file 8 of Drug utilization in patients starting haemodialysis with a focus on cardiovascular and antidiabetic medications: an epidemiological study in the Lazio region (Italy), 2016–2020
Creators: name: Kirchmayer, Ursula
name: Marino, Claudia
name: Feriozzi, Sandro
name: Massimetti, Carlo
name: Manzuoli, Micol
name: Angelici, Laura
name: Bargagli, Anna Maria
name: Cascini, Silvia
name: Addis, Antonio
name: Davoli, Marina
name: Agabiti, Nera
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Marine Biology
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Supplementary Material 8
Multiple Grammars and L2 Optionality: The Case of Acquisition at the External Interface
Creators: name: Bernardo-Hinesley, Sheryl
Publisher: name: Humanities Commons
Year: 2020
Subjects: subject: Second language acquisition
subject: Spanish language
subject: Linguistics
subject: FOS: Languages and literature

description: The  extension  of  Multiple  Grammars  theory  maintains  that  the  interlanguage grammar  of  adult  second  language  learners  is  composed  of multiple  competing sub-grammars  which  allow  for  optionality.  To  assess  the  presence  of  these competing sub-grammars, this article examines the second language acquisition of  Spanish  word  order  variation  by  first  language  English  speakers  of  three proficiency  levels:  low  beginning,  high  beginning,  and  low  intermediate.  As Spanish word order is flexible, learners must discern thecontext of use and the rules that constrain outwardly seeming free  alternations of Subject-Verb-Object and   Object-Verb-Subject   word   orders.   Learners   were   asked   to   verbalize pragmatically   felicitous   questions   to   sentences   with   transitive   verbs   with inanimate  direct  object  in  a  clitic-left  dislocation  structure. Results  using  two-way ANOVA confirm the coexistence of two competing features in the learners‟ interlanguage grammar representation. The data suggest that more exposure to L2  input  point  toward  better  mapping  of  the  discursive  sentence-final  focus position in Spanish.
sj-pdf-1-tec-10.1177_02711214211027625 – Supplemental material for Vocabulary Interventions for Young Emergent Bilingual Children: A Systematic Review of Experimental and Quasi-Experimental Studies
Creators: name: Kong, Na Young
name: Hurless, Nicole
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Education
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 130312 Special Education and Disability
subject: FOS: Educational sciences

description: Supplemental material, sj-pdf-1-tec-10.1177_02711214211027625 for Vocabulary Interventions for Young Emergent Bilingual Children: A Systematic Review of Experimental and Quasi-Experimental Studies by Na Young Kong and Nicole Hurless in Topics in Early Childhood Special Education
Eye disorders associated with selective serotonin reuptake inhibitors: a real-world disproportionality analysis of FDA adverse event reporting system
Creators: name: Li, Jiahao
name: Zhong, Rujia
name: Guo, Yi
name: Zhang, Feng
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health

description: Selective serotonin reuptake inhibitors (SSRIs) are widely used in depression and other psychiatric disorders. Despite their efficacy, there is a growing concern about the risk of eye disorders. This study aims to explore the potential correlation between eye disorders and SSRIs utilizing real-world data. The data were extracted from the US FDA Adverse Event Reporting System database from 2004Q1 to 2023Q3. The analysis focused on the clinical characteristics, the ranking of adverse reactions, the time-to-onset, and the severity proportion of SSRI-related eye disorders. Our analysis revealed that SSRIs were significantly associated with eye disorders, with a higher risk of vision blurred with escitalopram, angle closure glaucoma with citalopram, and photopsia with paroxetine. The most common eye disorders were vision blurred, visual impairment, mydriasis, etc. Most of these adverse events occurred within the first 30 days of treatment. The reported incidence of severe eye disorders was 38.6% for SSRIs, with fluoxetine exhibiting the highest rate at 45.9%. Our study demonstrates a significant association between SSRIs and the risk of eye disorders. These findings provide crucial insights for clinicians when prescribing SSRIs and underscore the need to monitor eye health in patients receiving these medications.
Propagation and Control of Broadband Optical and Radio Frequency Signals in Complex Environments
Creators: name: Liu, Bohao
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Electrical engineering not elsewhere classified
Classical and physical optics

description: A complex environment causes strong distortion of the field, inhibiting tasks such as imaging and communications in both the optical and radio-frequency (RF) region. In the optical regime, strong modal dispersion in highly multimode fiber (MMF) results in a scrambled output field in both space (intensity speckles) and time (spectral and temporal speckles). Taking advantage of the pulse shaping technique, spatial and temporal focusing has been achieved in this thesis, offering potential opportunities for nonlinear microscopy and imaging or space-division multiplexed optical communication through MMF. In the RF regime, multipath effect in wireless RF channel gives multiple echoes with random delay and amplitude attenuation at the receiver end. Static channel sounding and compensation with ultra-broadband spread spectrum technique resolves the issue by generating a peaking signal at the receiver, significantly improving the signal-to-noise/interference performance. However, the limited communication speed in the static approach makes it challenging for sounding and compensation in a dynamic channel. Here, we achieve real-time channel sounding and compensation for dynamic wireless multipath channel with 40 micro-seconds refresh rate by using a fast processing field programmable gate array (FPGA) unit, providing potential opportunities for mobile communications in indoor, urban, and other complex environments. Furthermore, by combining broadband photonics and RF radar technologies, a high depth and transverse resolution wide bandwidth (15 GHz) W-band (75 - 110 GHz) photonic monopulse-like radar system for remote target sensing is demonstrated, offering prospects for millimeter wave 3-D sensing and imaging.
sj-pdf-1-qch-10.1177_0272684X211033448 - Supplemental material for Electronic Hand Hygiene Quality and Duration Monitoring in Pre-School Children: A Feasibility Study
Creators: name: Mohd Rani, Mohd Dzulkhairi
name: Mohamed, Nurul Azmawati
name: Jamaluddin, Tengku Zetty Maztura Tengku
name: Ismail, Zarini
name: Ramli, Shalinawati
name: Faroque, Habibah
name: Samad, Farishah Nur Abd
name: Ariffien, Abdul Rasyid
name: Farid, Aisyah Ar Redha Che Amir
name: Isahak, Ilina
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-1-qch-10.1177_0272684X211033448 for Electronic Hand Hygiene Quality and Duration Monitoring in Pre-School Children: A Feasibility Study by Mohd Dzulkhairi Mohd Rani, Nurul Azmawati Mohamed, Tengku Zetty Maztura Tengku Jamaluddin, Zarini Ismail, Shalinawati Ramli, Habibah Faroque, Farishah Nur Abd Samad, Abdul Rasyid Ariffien, Aisyah Ar Redha Che Amir Farid and Ilina Isahak in International Quarterly of Community Health Education
sj-pdf-1-tag-10.1177_17562848211030050 – Supplemental material for Bowel ultrasound enhances predictive value based on clinical indicators: a scoring system for moderate-to-severe endoscopic activities in patients with ulcerative colitis
Creators: name: Zhang, Mengmeng
name: Zhang, Huimin
name: Zhu, Qingli
name: Bai, Xiaoyin
name: Zhou, Qingyang
name: Ruan, Gechong
name: Li, Wenbo
name: Ma, Li
name: Xiao, Mengsu
name: Yang, Hong
name: Qian, Jiaming
Publisher: name: SAGE Journals
Year: 2021
Subjects: Nutrition and Dietetics not elsewhere classified
Oncology and Carcinogenesis not elsewhere classified
Pharmacology and Pharmaceutical Sciences not elsewhere classified

description: Supplemental material, sj-pdf-1-tag-10.1177_17562848211030050 for Bowel ultrasound enhances predictive value based on clinical indicators: a scoring system for moderate-to-severe endoscopic activities in patients with ulcerative colitis by Mengmeng Zhang, Huimin Zhang, Qingli Zhu, Xiaoyin Bai, Qingyang Zhou, Gechong Ruan, Wenbo Li, Li Ma, Mengsu Xiao, Hong Yang and Jiaming Qian in Therapeutic Advances in Gastroenterology
sj-pdf-1-sci-10.1177_00368504211029812 – Supplemental material for Perception towards E-learning and COVID-19 on the mental health status of university students in Malaysia
Creators: name: Moy, Foong Ming
name: Ng, Yit Han
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Supplemental material, sj-pdf-1-sci-10.1177_00368504211029812 for Perception towards E-learning and COVID-19 on the mental health status of university students in Malaysia by Foong Ming Moy and Yit Han Ng in Science Progress
Authorial Affiliations or , The Clubbing and Collaborating of Brander Matthews
Creators: name: Margaret Ashton, Susanna
Publisher: name: Humanities Commons
Year: 1999
Subjects: subject: Authorship--Study and teaching
subject: American literature
subject: Americans--Social life and customs

description: Both the friends and enemies of Brander Matthews attested to his sociability. Clayton Hamilton wrote in 1929 that Matthews had a "genius in the gentle art of friendship." (86). Nicholas Murray Butler, President of Columbia University, observed that "Matthews knew everybody and everybody knew him" and Mark Twain even jokingly inscribed one of his books, "To B. M. From his only friend." (1) Although Matthews counted among his friends many prominent critics, writers, and politicians, (especially notable was his intimate friendship with Theodore Roosevelt), his congeniality and relentless socializing was not part of a program of professional networking. For Matthews, the ability to socialize was part of his identity as a specific kind of culture figure, that of a professional man of letters. As the cultural prestige accorded the romantic and solitary author wanted, Matthews came to embody a phenomenon that assigned cultural prestige to the practice of authorship as an activity most suited for men who could "mix."  Through his collaborative fiction, critical essays, indefatigable socializing, and, most importantly, his exchanges with other writers and literary figures, Brander Matthews drew together conflicting theories about the practice of writing in order to bolster the vision of romantic authorship for what he saw as the new and resolutely unromantic twentieth-century literary marketplace.
Prävalenz von Übergewicht und Adipositas bei deutschen Einschulkindern
Creators: name: Moß, A
name: Wabitsch, M.
name: Kromeyer-Hauschild, K.
name: Reinehr, T.
name: Kurth, Bärbel-Maria
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2007
Subjects: subject: Adipositas
subject: Übergewicht bei Kindern und Jugendlichen
subject: Schuleingangsuntersuchungen
subject: Datenlage
subject: 610 Medizin

description: Aus aktuellen Meldungen geht hervor, dass die Übergewichtsproblematik im Kindes- und Jugendalter hoch ist und die Zahl der Betroffenen weiter steigt. Entsprechend den Ergebnissen des Kinder- und Jugendgesundheitssurveys (KiGGS) sind 15 % der Kinder in Deutschland übergewichtig und 6,3 % adipös. Der Vergleich mit den Referenzdaten von Kromeyer-Hauschild aus den 1990er-Jahren lässt auf einen deutlichen Anstieg schließen. Eine weitere Informationsquelle zur Darstellung der Prävalenz von Übergewicht und Adipositas im zeitlichen Verlauf sind die regelmäßig durchgeführten Einschulungsuntersuchungen. Eine detaillierte Übersicht über die Prävalenzzahlen zu Übergewicht und Adipositas bei Einschülern der einzelnen Bundesländer war bislang nicht verfügbar. Mittels Internet- bzw. Literaturrecherche sowie Telefon- mit E-Mail-Kontakt wurden die Daten der Schuleingangsuntersuchungen der Bundesländer gesammelt, die Prävalenzangaben zusammengefasst und verglichen. Für Deutschland sind die Prävalenzzahlen zu Übergewicht und Adipositas bei Einschülern sehr uneinheitlich dokumentiert und partiell schwer zugänglich. Die Zahlen aus den verschiedenen Regionen zeigen eine auffallende Heterogenität. So liegt die Befundhäufigkeit für Übergewicht in Thüringen bei 7,2 %, in Bayern bei 9 % und in Mecklenburg-Vorpommern bei 13,6 %. Ähnliche Ergebnisse finden sich für die Adipositasprävalenz mit 3,6 % in Bayern und 6,1 % in Mecklenburg-Vorpommern (berechnet nach Kromeyer-Hauschild et al.). Die zusammenfassende Darstellung der Prävalenzangaben für Schulanfänger lässt ein Nord-Süd-Gefälle erkennen. Im langfristigen Trend ist die Häufigkeit von Übergewicht und Adipositas bei den Schuleingangsuntersuchungen gestiegen. In Brandenburg ist die Adipositasprävalenz seit einiger Zeit rückläufig, auch in einigen anderen Ländern deutet sich neuerdings eine Stagnation der Raten an. Die Schichtzugehörigkeit und der Migrantenstatus sind starke Determinanten für das Auftreten von Übergewicht und Adipositas. Ein Vergleich der Prävalenzen von Übergewicht und Adipositas bei Einschülern mit Ergebnissen aus Schuluntersuchungen im späteren Lebensalter zeigt, dass ein besorgniserregender Anstieg während der Adoleszenz stattfindet. Eine einheitliche und flächendeckende Erfassung und Auswertung der Körperhöhen- und Gewichtsdaten sowie der Werte für den Body-Mass-Index (BMI) im Rahmen der Schuleingangsuntersuchung wäre hilfreich, um aktuelle Trends zur Prävalenz von Übergewicht und Adipositas regional differenziert erkennen zu können und um die Wirkung präventiver Maßnahmen im Vorschulalter zu evaluieren.
Risk factors for drug-related non-infectious pneumonia: insights from the FDA adverse event reporting system (FAERS)
Creators: name: Meng, Peize
name: Zhang, Yi
name: Zhao, Qingnan
name: Zhang, Hang
name: Ruan, Zheng
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Mental Health

description: Non-infectious pneumonitis (NIP) is a severe adverse drug reaction. To better understand drug-induced NIP, improve patient safety, and inform clinical decision-making, this study aims to utilize the FDA Adverse Event Reporting System (FAERS) database to evaluate the association between medications and NIP, identify potential risk factors, and offer clinical alerts. We reviewed the FAERS database from the 2004 through the second quarter of 2024. Using ‘NIP’ as the search term, we sorted, counted, and analyzed cases by generic drug name and trends of reports related to NIP submitted to FAERS database. We employed four statistical methods to identify drugs associated with the NIP. From 21,433,114 reported drug adverse events (AEs), 9,224 cases were classified as NIP. Our analysis identified 20 drugs associated with NIP, with the main categories being antineoplastic agents, antibiotics and immunosuppressants. Daptomycin, methotrexate, and tacrolimus had the highest NIP-related deaths. Trends in AEs reporting indicate that the drugs showing the fastest increase in NIP reports are daptomycin, methotrexate, sertraline, and amiodarone. These findings could assist clinicians in the early identification of drug-related NIP and provide valuable insights for future research into the mechanisms underlying drug-related NIP.
Additional file 1 of Clinicopathological profile and management of thyroid carcinoma: a Sub-Saharan country experience
Creators: name: Elhassan, Moawia Mohammed Ali
name: Gismalla, Mohamed Dafalla Awadalla
name: Mohamed, Sahar Abdelrahman Hamid
name: Faggad, Areeg
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Chemical Sciences not elsewhere classified
Cancer

description: Supplementary Material 1: Data Collection Sheet
Supplementary Figure 1
Creators: name: Nascimento, Débora C
name: Costa Neto, João M
name: Solcà, Manuela S
name: Estrela-Lima, Alessandra
name: Barbosa, Vivian F
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 70706 Veterinary Medicine
subject: FOS: Veterinary sciences

description: Identification of traumatized patient
Kommunen, Länder, Bund und Europäische Gemeinschaft. Zuständigkeiten und Aufgaben bei Seuchennotfällen im Kontext der neuen Internationalen Gesundheitsvorschriften
Creators: name: Gottschalk, René
name: Dreesman, Johannes
name: Leitmeyer, Katrin
name: Krause, Gérard
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2009
Subjects: subject: Infektionsschutzgesetz
subject: Infektionskrankheit
subject: Seuchennotfall
subject: Öffentlicher Gesundheitsdienst
subject: Internationale Gesundheitsvorschriften
subject: infectious disease emergencies
subject: public health protection authorities
subject: infection protection law
subject: international health regulations
subject: 610 Medizin

description: Die weltweite Ausbreitung und Zunahme von Infektionskrankheiten sind wesentliche Herausforderungen für den öffentlichen Gesundheitsdienst. Dies gilt nicht nur für eine möglicherweise drohende Influenzapandemie, sondern auch für andere, bislang kaum oder gar nicht bekannte Infektionskrankheiten, z. B. für das Severe Acute Respiratory Syndrome (SARS), wie die erste Pandemie dieses Jahrtausends eindrücklich zeigte. Zunehmend wird auch die Gefahr bioterroristischer Anschläge mit in die Planungen des Managements von Seuchennotfällen einbezogen. In Deutschland sind die diesbezüglichen politischen und fachlichen Zuständigkeiten komplex, da die Gesetzgebungskompetenz für Gesundheitsfragen bei den Bundesländern liegt. Die Ausführungsorgane für die Maßnahmen bei Seuchennotfällen sind die regional zuständigen Gesundheitsämter. Ihnen übergeordnet sind Fachbehörden der Länder und des Bundes. Da Infektionskrankheiten häufig grenzüberschreitend auftreten, ist mit dem European Centre for Disease Prevention and Control (ECDC) eine europäische Behörde zur Identifizierung und Bewertung von Infektionskrankheiten, einschließlich Seuchennotfällen eingerichtet worden.
description: Pandemic preparedness has become a catch phrase for politicians, government agencies and communities, both nationally and internationally. This is due to the increasing number of infectious diseases emergencies that are important challenges for health protection authorities, which was shown impressively when SARS emerged as the first pandemic in this millennium. In Germany, effective and efficient infection control is complex, with local health protection authorities having their own responsibilities. In the case of an emergency epidemic, regional health departments are responsible. Having authority over these are authorities on the federal state level as well as on the federal level. For the European Community, the European Centre for Disease Prevention and Control (ECDC) was established. The mission of this agency is to identify, assess and communicate current and emerging threats to human health posed by infectious diseases.
Surveillance von Infektionskrankheiten auf europäischer Ebene
Creators: name: Ammon, Andrea
name: Faensen, Daniel
Publisher: name: Robert Koch-Institut
Year: 2009
Subjects: subject: Surveillance
subject: ECDC
subject: Datenqualität
subject: elektronische Datenerfassung
subject: Surveillance-Netzwerke
subject: surveillance
subject: data quality
subject: electronic data collection
subject: surveillance networks
subject: 610 Medizin

description: Mit der im Jahr 1998 von EU-Parlament und Ministerrat getroffenen Entscheidung zur Etablierung eines EU-weiten Netzwerks zur Überwachung von Infektionskrankheiten wurde die Grundlage für die EUweite Surveillance geschaffen. Seit Mai 2005 hat das Europäische Zentrum für die Prävention und die Kontrolle von Krankheiten (ECDC) die Aufgabe, dieses Netzwerk zu koordinieren und weiterzuentwickeln. Eine der Hauptfunktionen des ECDC besteht darin, die europäische Infektionsüberwachung zu standardisieren und insbesondere die Verfahrensweisen der weitgehend voneinander unabhängigen Surveillance-Netzwerke zu vereinheitlichen. Als einer der ersten Schritte wurden in Zusammenarbeit mit den Mitgliedsstaaten die EU-Falldefinitionen für die Surveillance revidiert. Die Surveillance-Netzwerke werden derzeit nach einem standardisierten Protokoll evaluiert, bevor im ECDC eine Entscheidung über die Zukunft der einzelnen Netzwerkaktivitäten getroffen wird. Parallel wurde mit der Entwicklung eines einheitlichen Datenerfassungssystems (The European Surveillance System, TESSy) begonnen. Seit Beginn 2008 werden die Nutzer spezifisch geschult. TESSy ist seit April 2008 funktionsfähig. Zukünftig muss das Hauptaugenmerk auf die Qualität und Vergleichbarkeit der Daten gerichtet sein, da nur valide und vergleichbare Daten eine gute Grundlage für Entscheidungen im Gesundheitsbereich sind.
description: The basis for EU wide surveillance was Decision 2119/98/EC of the European Parliament and the Council in 1998. Since May 2005 it is the task of the European Centre for Disease Prevention and Control to coordinate and further develop this network. One key function of the ECDC is to standardise European surveillance and especially to harmonise the procedures of the surveillance networks that developed independently of each other. As a first step, the EU case definitions have been revised jointly with the Member States and the Commission. All surveillance networks are evaluated with a standard protocol before a decision is made at the ECDC on the continuation of the individual network activities. Simultaneously, the development of The European Surveillance System (TESSy) progressed. Since the beginning of 2008 data users have been trained and TESSy has been in use since April 2008. In the future the main focus must be the improvement of the quality and comparability of the data as such data are the essential prerequisite for decision making in public health.
EFFECTIVE SCHOOL LEADERSHIP CHARACTERISTICS OF DUAL LANGUAGE EDUCATION PRINCIPALS
Creators: name: Parsons, Michael
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Educational administration, management and leadership

description: The purpose of this mixed-methods study is to explore leadership characteristics dual language school principals possess to effectively lead a dual language program. The research seeks to identify specific leadership characteristics and qualities necessary for a principal to effectively lead a dual language school compared to the leadership characteristics required to lead a traditional/monolingual school. The researcher examined the perceptions of leadership responsibilities with dual language teachers in an urban school district in southern Washington. This research study was compared with a similar study completed with monolingual teachers in an urban school district in western Wisconsin. The researcher used an electronic survey, via Qualtrics, to gather demographic information and determine the rank order perceptions of the 21 leadership responsibilities according to dual language teachers. A total of 17 teachers participated in the research study. The highest rated leadership responsibility among the dual language teachers was Communication and the lowest rated leadership responsibility was Contingent Rewards. The researcher also implemented a collective case study design to accumulate and analyze data regarding the leadership characteristics of two dual language school principals, via semi-structured interviews. A recommendation from this study is that several of the 21 leadership responsibilities are more applicable to increasing student achievement in dual language classrooms compared to monolingual classrooms.
Cytomegaloviruses inhibit Bak- and Bax-mediated apoptosis with two separate viral proteins
Creators: name: Cam, M.
name: Handke, Wiebke
name: Picard-Maureau, M.
name: Brune, Wolfram
Publisher: name: Robert Koch-Institut
Year: 2009
Subjects: subject: apoptosis
subject: cytomegalovirus
subject: m41.1
subject: Bak
subject: Bax
subject: 610 Medizin

description: Apoptosis of infected cells can limit virus replication and serves as an innate defense mechanism against viral infections. Consequently, viruses delay apoptosis by expressing antiapoptotic proteins, many of which structurally resemble the cellular antiapoptotic protein Bcl-2. Like Bcl-2, the viral analogs inhibit apoptosis by preventing activation and/or oligomerization of the proapoptotic mitochondrial proteins Bax and Bak. Here we show that cytomegaloviruses (CMVs) have adopted a different strategy. They encode two separate mitochondrial proteins that lack obvious sequence similarities to Bcl-2-family proteins and specifically counteract either Bax or Bak. We identified a small mitochondrion-localized protein encoded by the murine CMV open reading frame (ORF) m41.1, which functions as a viral inhibitor of Bak oligomerization (vIBO). It blocks Bak-mediated cytochrome c release and Bak-dependent induction of apoptosis. It protects cells from cell death-inducing stimuli together with the previously identified Bax-specific inhibitor viral mitochondria-localized inhibitor of apoptosis (vMIA) (encoded by ORF m38.5). Similar vIBO proteins are encoded by CMVs of rats, and possibly by other CMVs as well. These results suggest a non-redundant function of Bax and Bak during viral infection, and a benefit for CMVs derived from the ability to inhibit Bak and Bax separately with two viral proteins.
sj-pdf-1-imr-10.1177_03000605211027774 - Supplemental material for Sporadic hemangioblastoma of the kidney: a clinicopathologic study of three cases and a literature review
Creators: name: Xu, Yanmei
name: Ma, Xuehua
name: Ma, Yong
name: Li, Juan
name: Zhang, Renya
name: Li, Xiaomei
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Health and Community Services
subject: Cardiology
subject: Dentistry not elsewhere classified
subject: Emergency Medicine
subject: Endocrinology
subject: Geriatrics and Gerontology
subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Nursing not elsewhere classified
subject: Nutrition and Dietetics not elsewhere classified
subject: Oncology and Carcinogenesis not elsewhere classified
subject: Orthopaedics
subject: Sports Medicine
subject: Otorhinolaryngology
subject: Aged Health Care
subject: Paediatrics
subject: Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: Psychology not elsewhere classified
subject: Psychiatry (incl. Psychotherapy)
subject: Public Health and Health Services not elsewhere classified
subject: Respiratory Diseases
subject: Sociological Methodology and Research Methods
subject: Surgery

description: Supplemental material, sj-pdf-1-imr-10.1177_03000605211027774 for Sporadic hemangioblastoma of the kidney: a clinicopathologic study of three cases and a literature review by Yanmei Xu, Xuehua Ma, Yong Ma, Juan Li, Renya Zhang and Xiaomei Li in Journal of International Medical Research
Anaphylactic risk associated with iodinated and gadolinium-based contrast media
Creators: name: Bian, Sainan
name: Wang, Zixi
name: Li, Lisha
name: Cui, Le
name: Xu, Yingyang
name: Guan, Kai
name: Zhao, Bin
name: Xue, Huadan
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: Mental Health

description: This study aimed to analyze the risk signals of iodinated and gadolinium-based contrast media associated with anaphylaxis. Data from the United States Food and Drug Administration Adverse Event Reporting System (FAERS) were retrospectively reviewed from January 2004 to September 2022. Disproportionality and Bayesian analyses were used in data mining to screen for suspected anaphylaxis using contrast media. A total of 1240 reports of anaphylaxis associated with contrast media were identified (464 men, 37.4%). The average age of anaphylaxis associated with iodinated contrast media (ICM) and gadolinium-based contrast media (GBCM) was 56.8 ± 17.2 and 50.9 ± 18.0 years old, respectively (p < .001). Among ICM, iopamidol showed the highest reporting odds ratio (ROR) (29.0), and amidotrizoate showed the lowest ROR (7.4). Among low-osmolality ICM, iopamidol had the highest ROR (29.0), and iopromide had the lowest ROR (8.8). Among the macrocyclic agents, gadoteridol had the highest ROR (37.3), while gadoterate meglumine had the lowest (10.4). Among the linear agents, gadobenate dimeglumine had the highest ROR (28.8), and gadodiamide had the lowest (1.4). The mortality rate in ICM was significantly higher than that in GBCM (p < 0.001). This study provides clinicians and pharmacists evidence for risk signals of anaphylactic reactions among contrast agents.
Empfehlung des Verbunds für angewandte Hygiene (VAH) zu Formaldehyd
Creators: name: Schwebke, Ingeborg
name: Bischoff, Heribert
name: Herr, Caroline
name: Kramer, Axel
name: Eikmann, Thomas
Publisher: name: Robert Koch-Institut
Year: 2007
Subjects: subject: Empfehlung
subject: Formaldehyd
subject: VAH
subject: Verbund für angewandte Hygiene
subject: 610 Medizin

description: Aufgrund der Neubewertung von Formaldehyd durch das Bundesinstitut für Risikobewertung (BfR) wurde vom Verbund für angewandte Hygiene (VAH) eine Arbeitsgruppe mit dem Auftrag gegründet, eine Stellungnahme bzw. Empfehlung des VAH (gemeinsam mit den Fachgesellschaften, dem BfR und dem RKI) zu den Möglichkeiten der zukünftigen Anwendung von Formaldehyd im Gesundheitswesen zu erarbeiten. Diese Arbeitsgruppe konstituierte sich am 12.10.2006 in München. Inhaltliche Grundlagen zur Erstellung der Empfehlung waren dabei Veröffentlichungen zur Bewertung der relevanten toxikologischen Daten (Appel et al. 2006), zur aktuellen Exposition in Gesundheitseinrichtungen (Eickmann und Thullner 2006) sowie zu den Konsequenzen bei Einführung des vorgeschlagenen Safe Level (Eikmann et al. 2006). Formaldehyd ist ein hinsichtlich seiner umfassenden Wirksamkeit und deren nur unbedeutender Beeinflussung durch organische Belastungen ein bewährtes Desinfektionsmittel. Die Wirksamkeit wird nicht durch den pH-Wert beeinflusst. Lösungen zeichnen sich durch eine lange Haltbarkeit und geringe Korrosivität aus. Die toxikologische Bewertung der WHO aus dem Jahre 2004 und die Festlegung eines Grenzwertes für die Raumluft durch das BfR verlangen jedoch ein Überdenken der bisherigen Anwendungspraxis von Formaldehyd im Bereich des (öffentlichen) Gesundheitswesens.
EFFECTS ON RHEOLOGY AND HYDRATION OF THE ADDITION OF CELLULOSE NANOCRYSTALS (CNC) IN PORTLAND CEMENT
Creators: name: Sr., Francisco J Montes
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Nanomaterials
Construction materials
Inorganic materials (incl. nanomaterials)
Macromolecular materials
Structure and dynamics of materials
Materials engineering not elsewhere classified
Civil engineering not elsewhere classified

description: Cellulose Nanocrystals have been used in a wide range of applications including cement composites as a strength enhancer. This work analyses the use of CNC from several sources and production methods, and their effects on rheology and hydration of pastes made using different cement types with different compositions. Cement Types I/II and V were used to prepare pastes with different water to cement ratios (w/c) and measure the changes in rheology upon CNC addition. The presence of tricalcium aluminate (cement chemistry denotes as C3A) made a difference in the magnitude of CNC effects. At dosages under 0.5vol% to dry cement, CNC reduced the yield stress up to 50% the control value. Pastes with more C¡A reduced yield stress over a wider range of CNC dosages. CNC also increased yield stress of pastes with dosages above 0.5%, twice the control value for pastes with high C3A content at 1.5% CNC and up to 20 times for pastes without C3A at the same dosage.
All the CNCs used were characterized in length, aspect ratio, and zeta potential to identify a definitive factor that governs the effect in the rheology of cement pastes. However, no definitive evidence was found that any of these characteristics dominated the measured effects.
The CNC dosage at which the maximum yield stress reduction occurred increased with the amount of water used in the paste preparation, which provides evidence of the dominance of the water to cement ratio in the rheological impact of CNC.
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Isothermal calorimetry showed that CNC cause concerning retardation effects in cement hydration. CNC slurries were then tested for sugars and other carbohydrates that could cause the aforementioned effect, then slurries were filtered, and impurities were detected in the filtrate, these impurities were quantified and characterized, however, the retardation appeared to be unaffected by the amount of the species detected, suggesting that the crystal chemistry, which is a consequence of the production method, is responsible of this retardation.
This work explores the benefits and drawbacks of the use of CNC in cement composites by individually approaching rheology and heat of hydration on a range of physical and chemical tests to build a better understanding of the observed effects.
Understanding the effect of CNCs on cement paste rheology can provide insights for future work of CNCs applications in cement composites.
Additional file 1 of Discovery biomarker to optimize obeticholic acid treatment for non-alcoholic fatty liver disease
Creators: name: Lee, Seung Min
name: Jun, Dae Won
name: Yoon, Eileen Laurel
name: Oh, Ju Hee
name: Roh, Yoon Jin
name: Lee, Eun Jeoung
name: Shin, Ji-Hee
name: Nam, Young-Do
name: Kim, Hyun Sung
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Supplementary Material 1
sj-pdf-1-nms-10.1177_14614448211027173 – Supplemental material for Writer movements between news outlets reflect political polarization in media
Creators: name: Hagar, Nick
name: Wachs, Johannes
name: Horvát, Emőke-Ágnes
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications

description: Supplemental material, sj-pdf-1-nms-10.1177_14614448211027173 for Writer movements between news outlets reflect political polarization in media by Nick Hagar, Johannes Wachs and Emőke-Ágnes Horvát in New Media & Society
Large Q fever outbreak due to sheep farming near residential areas, Germany, 2005
Creators: name: Gilsdorf, Andreas
name: Kroh, C.
name: Grimm, S.
name: Jensen, Evelin
name: Wagner-Wiening, Christiane
name: Alpers, Katharina
Publisher: name: Robert Koch-Institut
Year: 2007
Subjects: subject: Adolescent
subject: Humans
subject: Female
subject: Disease Outbreaks
subject: Germany/epidemiology
subject: Male
subject: Middle Aged
subject: Risk Factors
subject: Animals
subject: Antibodies
subject: Adult
subject: Rural Health/statistics & numerical data
subject: Bacterial/blood
subject: Enzyme-Linked Immunosorbent Assay
subject: Q Fever/epidemiology
subject: Q Fever/transmission
subject: Q Fever/veterinary
subject: Sheep
subject: Sheep Diseases/transmission
subject: Zoonoses/epidemiology
subject: Zoonoses/transmission
subject: 610 Medizin

description: In June 2005 Coxiella burnetii-infected sheep, grazing and lambing on a meadow bordering a residential area, caused a large Q fever outbreak (331 cases) in Germany. Our outbreak investigation provided attack rates (AR) by distance between residence and meadow, sex and age groups. The AR of people living within 50 m of the meadow was 11·8%. It decreased the further the residence was from the meadow, falling to 1·3% at 350–400 m distance (RR 8·7, 95% CI 4·5–17·1). The AR was higher in men (RR 1·4, 95% CI 1·1–1·8). In the 25–64 years age group, the AR was 2·3 times higher compared to other age groups (95% CI 1·7–3·0). The distance-related AR showed a relationship between risk of infection and living close to the meadow. Ongoing urbanization will probably lead to further Q fever outbreaks, hence prevention activities undertaken by animal and public health practitioners should be aligned and strengthened.
sj-docx-1-pbi-10.1177_10983007211020784 – Supplemental material for A Systematic Review of General Educator Behavior Management Training
Creators: name: Samudre, Mark D.
name: LeJeune, Lauren M.
name: Ascetta, Kate E.
name: Dollinger, Hannah
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Education
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 130312 Special Education and Disability
subject: FOS: Educational sciences

description: Supplemental material, sj-docx-1-pbi-10.1177_10983007211020784 for A Systematic Review of General Educator Behavior Management Training by Mark D. Samudre, Lauren M. LeJeune, Kate E. Ascetta and Hannah Dollinger in Journal of Positive Behavior Interventions