cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Dynamics of entanglement among the environment oscillators of many-body systems
Creators: name: Paula, A. L. de
name: Freitas, Dagoberto S.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In this work we extend the discussion that was began in the Ref. [A. L. de Paula Jr., J. G. G. de Oliveira Jr., J. G. Peixoto de Faria, Dagoberto S. Freitas and M. C. Nemes, {\it Phys. Rev.} {\bf A89}, (2014) 022303] to deal with the dynamics of the concurrence of a many-body system. In that previous paper, the discussion was focused in the residual entanglement between the partitions of the system. The purpose of the present contribution is to shed some light on the dynamical properties of entanglement among the environment oscillators. We consider a system consisting of a harmonic oscillator linearly coupled to N others and solve the corresponding dynamical problem analytically. We divide the environment in arbitrary two partitions and the entanglement dynamics between any of these partitions is quantified and it shows that in the case that excitations in each partitions are equal, the concurrence reaches the value one and the two partition of the environment are maximally entangled. For long times the excitations of the main oscillator are completely transferred to environment and the environment oscillators are found entangled.
Type IV fimbrial biogenesis, protease secretion, natural transformation, and virulence of Dichelobacter nodosus
Creators: name: Han., Xiaoyan
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Egocentric and allocentric reference frames can flexibly support contextual cueing
Creators: name: Zheng, Lei
name: Dobroschke, Jan-Gabriel
name: Pollmann, Stefan
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: Egocentric
subject: Allocentric
subject: Reference frame
subject: Contextual cueing
subject: Visual attention
subject: 150

description: We investigated if contextual cueing can be guided by egocentric and allocentric reference frames. Combinations of search configurations and external frame orientations were learned during a training phase. In Experiment 1, either the frame orientation or the configuration was rotated, thereby disrupting either the allocentric or egocentric and allocentric predictions of the target location. Contextual cueing survived both of these manipulations, suggesting that it can overcome interference from both reference frames. In contrast, when changed orientations of the external frame became valid predictors of the target location in Experiment 2, we observed contextual cueing as long as one reference frame was predictive of the target location, but contextual cueing was eliminated when both reference frames were invalid. Thus, search guidance in repeated contexts can be supported by both egocentric and allocentric reference frames as long as they contain valid information about the search goal.
Additional file 1 of Concordance between influential adverse treatment outcomes and localized prostate cancer treatment decisions
Creators: name: Pozzar, Rachel A.
name: Xiong, Niya
name: Hong, Fangxin
name: Filson, Christopher P.
name: Chang, Peter
name: Halpenny, Barbara
name: Berry, Donna L.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. Predictors of concordance between the influence of potential adverse treatment outcomes and localized prostate cancer treatment decisions.
Statistical theory of relaxation of high energy electrons in quantum Hall edge states
Creators: name: Lunde, Anders Mathias
name: Nigg, Simon E.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We investigate theoretically the energy exchange between electrons of two co-propagating, out-of-equilibrium edge states with opposite spin polarization in the integer quantum Hall regime. A quantum dot tunnel-coupled to one of the edge states locally injects electrons at high energy. Thereby a narrow peak in the energy distribution is created at high energy above the Fermi level. A second downstream quantum dot performs an energy resolved measurement of the electronic distribution function. By varying the distance between the two dots, we are able to follow every step of the energy exchange and relaxation between the edge states - even analytically under certain conditions. In the absence of translational invariance along the edge, e.g. due to the presence of disorder, energy can be exchanged by non-momentum conserving two-particle collisions. For weakly broken translational invariance, we show that the relaxation is described by coupled Fokker-Planck equations. From these we find that relaxation of the injected electrons can be understood statistically as a generalized drift-diffusion process in energy space for which we determine the drift-velocity and the dynamical diffusion parameter. Finally, we provide a physically appealing picture in terms of individual edge state heating as a result of the relaxation of the injected electrons.
description: 13 pages plus 6 appendices, 8 figures. Supplemental Material can be found on http://quantumtheory.physik.unibas.ch/people/nigg/supp_mat.html
NKT cells in normal and autoimmune-disease prone mice
Creators: name: Hammond., Kirsten Jenna Louise
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field. Winner of the Mollie Holman Doctoral Medal for Excellence
A systematic analysis of covert channels in the Network Time Protocol
Creators: name: Hielscher, Jonas
name: Lamshöft, Kevin
name: Krätzer, Christian
name: Dittmann, Jana
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: Network Covert Channels
subject: Steganography
subject: Network Time Protocol
subject: Network Security
subject: Network Protocol Security
subject: 000

description: Covert channels in network protocols are a technique aiming to hide the very existence of secret communication in computer networks. In this work we present a systematic in-depth analysis of covert channels by modification for the Network Time Protocol (NTP). Our analysis results in the identification of 49 covert channels, by applying a covert channel pattern-based taxonomy. The summary and comparison based on nine selected key attributes show that NTP is a plausible carrier for covert channels. The analysis results are evaluated in regards to common behavior of NTP implementations in six major operating systems. Two channels are selected and implemented to be evaluated in network test-beds. By hiding encrypted high entropy data in a high entropy field of NTP we show in our first assessment that practically undetectable channels can be implemented in NTP, motivating the required further research. In our evaluation, we analyze 40,000 NTP server responses from public NTP server providers. We discuss the general approach of the research community that detection of covert channels is the more promising countermeasure, compared to active suppression of covert channels. Therefore, normalization approaches and a secure network environment are introduced.
Changes in cardiovascular reactivity of the rat : a role for the vascular endothelium
Creators: name: Hammer., Leah W.
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
The presynaptic scaffold protein Bassoon in forebrain excitatory neurons mediates hippocampal circuit maturation : potential involvement of TrkB signalling
Creators: name: Annamneedi, Anil
name: Angel, Miguel
name: Gundelfinger, Eckart D.
name: Stork, Oliver
name: Çalişkan, Gürsel
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: Bassoon
subject: Hippocampus
subject: TrkB
subject: Neurogenesis
subject: fEPSP
subject: Glutamatergic presynapse
subject: 570

description: presynaptic active zone organizer protein Bassoon orchestrates numerous important functions at the presynaptic active zone. We previously showed that the absence of Bassoon exclusively in forebrain glutamatergic presynapses (BsnEmx1cKO) in mice leads to developmental disturbances in dentate gyrus (DG) affecting synaptic excitability, morphology, neurogenesis and related behaviour during adulthood. Here, we demonstrate that hyperexcitability of the medial perforant path-to-DG (MPP-DG) pathway in BsnEmx1cKO mice emerges during adolescence and is sustained during adulthood. We further provide evidence for a potential involvement of tropomyosin-related kinase B (TrkB), the high-affinity receptor for brain-derived neurotrophic factor (BDNF), mediated signalling. We detect elevated TrkB protein levels in the dorsal DG of adult mice (~3–5 months-old) but not in adolescent (~4–5 weeks-old) mice. Electrophysiological analysis reveals increased field-excitatorypostsynaptic- potentials (fEPSPs) in the DG of the adult, but not in adolescent BsnEmx1cKO mice. In line with an increased TrkB expression during adulthood in BsnEmx1cKO, blockade of TrkB normalizes the increased synaptic excitability in the DG during adulthood, while no such effect was observed in adolescence. Accordingly, neurogenesis, which has previously been found to be increased in adult BsnEmx1cKO mice, was unaffected at adolescent age. Our results suggest that Bassoon plays a crucial role in the TrkB-dependent postnatal maturation of the hippocampus.
SFPD : simultaneous face and person detection in real-time for human-robot interaction
Creators: name: Fiedler, Marc-André
name: Werner, Philipp
name: Khalifa, Aly
name: Hamadi, Ayoub
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: Face detection
subject: Person detection
subject: Multi-task learning
subject: Real-time detection
subject: 621.3

description: Face and person detection are important tasks in computer vision, as they represent the first component in many recognition systems, such as face recognition, facial expression analysis, body pose estimation, face attribute detection, or human action recognition. Thereby, their detection rate and runtime are crucial for the performance of the overall system. In this paper, we combine both face and person detection in one framework with the goal of reaching a detection performance that is competitive to the state of the art of lightweight object-specific networks while maintaining real-time processing speed for both detection tasks together. In order to combine face and person detection in one network, we applied multi-task learning. The difficulty lies in the fact that no datasets are available that contain both face as well as person annotations. Since we did not have the resources to manually annotate the datasets, as it is very time-consuming and automatic generation of ground truths results in annotations of poor quality, we solve this issue algorithmically by applying a special training procedure and network architecture without the need of creating new labels. Our newly developed method called Simultaneous Face and Person Detection (SFPD) is able to detect persons and faces with 40 frames per second. Because of this good trade-off between detection performance and inference time, SFPD represents a useful and valuable real-time framework especially for a multitude of real-world applications such as, e.g., human–robot interaction.
Integrated cycles for urban biomass as a strategy to promote a CO2-neutral society : a feasibility study
Creators: name: Meinusch, Nicole
name: Kramer, Susanne
name: Körner, Oliver
name: Wiese, Jürgen
name: Seick, Ingolf
name: Beblek, Anita
name: Berges, Regine
name: Illenberger, Bernhard
name: Illenberger, Marco
name: Uebbing, Jennifer
name: Wolf, Maximilian
name: Saake, Gunter
name: Benndorf, Dirk
name: Reichl, Udo
name: Heyer, Robert
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: Integrated cycles for urban biomass
subject: Biogas
subject: Carbon footprint
subject: Sustainability
subject: Renewable energy
subject: Plant cultivation
subject: CO2-neutral society
subject: 610.72

description: The integration of closed biomass cycles into residential buildings enables efficient resource utilization and avoids the transport of biowaste. In our scenario called Integrated Cycles for Urban Biomass (ICU), biowaste is degraded on-site into biogas that is converted into heat and electricity. Nitrification processes upgrade the liquid fermentation residues to refined fertilizer, which can be used subsequently in house-internal gardens to produce fresh food for residents. Our research aims to assess the ICU scenario regarding produced amounts of biogas and food, saved CO2 emissions and costs, and social–cultural aspects. Therefore, a model-based feasibility study was performed assuming a building with 100 residents. The calculations show that the ICU concept produces 21% of the annual power (electrical and heat) consumption from the accumulated biowaste and up to 7.6 t of the fresh mass of lettuce per year in a 70 m2 professional hydroponic production area. Furthermore, it saves 6468 kg CO2-equivalent (CO2-eq) per year. While the ICU concept is technically feasible, it becomes economically feasible for large-scale implementations and higher food prices. Overall, this study demonstrates that the ICU implementation can be a worthwhile contribution towards a sustainable CO2-neutral society and decrease the demand for agricultural land.
The clinical significance of A2ML1 variants in Noonan syndrome has to be reconsidered
Creators: name: Brinkmann, Julia
name: Lißewski, Christina
name: Pinna, Valentina
name: Vial, Yoann
name: Pantaleoni, Francesca
name: Lepri, Francesca
name: Daniele, Paola
name: Burnyte, Birute
name: Cuturilo, Goran
name: Fauth, Christine
name: Gezdirici, Alper
name: Kotzot, Dieter
name: Güleç, Elif Yılmaz
name: Iotova, Violeta
name: Schanze, Denny
name: Ramond, Francis
name: Havlovicová, Markéta
name: Utine, Gulen Eda
name: Simsek-Kiper, Pelin Ozlem
name: Stoyanova, Milena
name: Verloes, Alain
name: Luca, Alessandro
name: Tartaglia, Marco
name: Cavé, Hélène
name: Zenker, Martin
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: Noonan syndrome
subject: Clinical significance
subject: RASopathies
subject: 610.72

description: The RASopathies are a group of clinically and genetically heterogeneous developmental disorders caused by dysregulation of the RAS/MAPK signalling pathway. Variants in several components and regulators of this pathway have been identified as the pathogenetic cause. In 2015, missense variants in A2ML1 were reported in three unrelated families with clinical diagnosis of Noonan syndrome (NS) and a zebrafish model was presented showing heart and craniofacial defects similar to those caused by a NS-associated Shp2 variant. However, a causal role of A2ML1 variants in NS has not been confirmed since. Herein, we report on 15 individuals who underwent screening of RASopathy-associated genes and were found to carry rare variants in A2ML1, including variants previously proposed to be causative for NS. In cases where parental DNA was available, the respective A2ML1 variant was found to be inherited from an unaffected parent. Seven index patients carrying an A2ML1 variant presented with an alternate disease-causing genetic aberration. These findings underscore that current evidence is insufficient to support a causal relation between variants in A2ML1 and NS, questioning the inclusion of A2ML1 screening in diagnostic RASopathy testing.
Endothelium-dependent relaxation and hyperpolarization in arteries of guinea-pig
Creators: name: Hammarström., Anna K.M.
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Additional file 1 of Study protocol: Evaluation of the ‘Flavour School’ sensory food education programme: a cluster-randomised controlled trial in UK primary school children, aged 4–7 years, to determine impact on confidence and curiosity in tasting vegetables and fruit
Creators: name: Wilkinson, Nicholas M.
name: Kannan, Srimathi
name: Ganguri, Harish
name: Hetherington, Marion M.
name: Evans, Charlotte E. L.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy

description: Additional file 1: Appendix 1. Details of the ‘Flavour Explorers’ activity used before and after intervention for observing children’s tasting behaviour, and gathering behavioural data. Appendix 2. Video coding regime. Appendix 3. Teacher Survey. Appendix 4. Caregiver consent form.
Splash Detail Due to Grain Incident on Granular Bed
Creators: name: Tanabe, Takahiro
name: Koike, Tomoki
name: Shimada, Takashi
name: Ito, Nobuyasu
name: Nishimori, Hiraku
Publisher: name: arXiv
Year: 2016
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Using the discrete element method (DEM), we study the splash processes induced by the impact of a grain on two types of granular beds, namely, randomly packed and FCC-structured beds.Good correspondence is obtained between our numerical results and the findings of previous experiments, and it is demonstrated that the packing structure of the granular bed strongly affects the splash process.The mean ejection angle for the randomly packed bed is consistent with previous experimental results. The FCC-structured bed yields a larger mean ejection angle; however, the latter result has not been confirmed experimentally. Furthermore, the ejection angle distributions and the vertical ejection speeds for individual grains vary depending on the relative timing at which the grains are ejected after the initial impact. Obvious differences are observed between the distributions of grains ejected during the earlier and later splash periods: the form of the vertical ejection speed distribution varies from a power-law form to a lognormal form with time, and more than 80\% of the kinetic energy of all ejected grains is used for earlier ejected grains.
description: 8 pages, 10 figures
Additional file 1 of Management of paediatric traumatic brain injury in Sweden: a national cross-sectional survey
Creators: name: Wickbom, Fredrik
name: Persson, Linda
name: Olivecrona, Zandra
name: Undén, Johan
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Molecular Biology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1. STROBEStatement—Checklist of items that should be included in reports ofcross-sectional studies.
Are existing quality-of-life instruments in cutaneous T-cell lymphoma of sufficient quality?
Creators: name: Gabes, Michaela
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: Quality-of-life instruments
subject: Cutaneous T-cell lymphoma
subject: Non-Hodgkin lymphoma
subject: 610.72

description: Cutaneous T-cell lymphoma (CTCL) is a rare type of non-Hodgkin lymphoma. However, non-Hodgkin lymphoma is ranked as the seventh most common cancer in the USA.1 In CTCL, mutated T cells migrate to the skin, and lesions on the skin tend to appear. Mycosis fungoides (MF) and Sézary syndrome (SS) are the most prevalent forms of CTCL.2 Pruritus, one of the most prominent symptoms of the disease, often leads to scratching, which in turns causes painful skin and can lead to disfigurement of affected patients. This negatively impacts their quality of life (QoL).3 Instruments measuring QoL are of great interest as they capture the patient’s perspective. Their use in clinical trials is increasingly recognized by regulatory authorities, clinicians and patients because they help to indicate whether the impact of an intervention is comprehensively assessed.4 In this issue of the BJD, Bhat et al.5 use qualitative research to assess the impact of CTCL on patients’ daily lives and to identify the most meaningful aspects in assessing QoL in CTCL. This is achieved by evaluating existing QoL instruments (generic, skin specific and disease specific). Generic instruments (e.g. the 36-Item Short-Form Health Survey) and skin-specific instruments (e.g. the Dermatology Life Quality Index) cannot capture CTCL-specific constructs. However, the only existing CTCL-specific measure, the MF/SS-CTCL instrument, did not include patients with advanced-stage disease in either the development or validation.6 In their study, Bhat et al. included patients at all stages of the disease. This assessment across various severity stages is novel. Eighteen semistructured interviews revealed three major themes: clinical symptoms, psychological and social functioning, and the salient treatment burden. Existing QoL instruments were screened for relevant patient concerns identified in the interviews. In particular, individual clinical symptoms, concerns about appearance and problems with sleep were not adequately represented in either generic or skin-specific instruments, or in the only existing CTCL-specific QoL measure. For this reason, there is currently no available QoL instrument of sufficient quality in CTCL. Qualitative research involving affected patients, as performed by the authors, is the gold standard for the development of a promising patient-reported outcome measure. Without patient input, the content validity of a new instrument can be questioned. Only patients are able to judge the impact of their disease, their feelings and their treatment burden. For this reason, this study including interviews with patients with variations in severity represents an excellent starting point for the development of a new, comprehensive, disease-specific QoL instrument of sufficient quality for patients with CTCL.
Left atrial appendage occlusion device causing coronary obstruction : a word of caution
Creators: name: Kuzmin, Boris
name: Staack, Thorsten
name: Wippermann, Jens
name: Wacker, Max
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: Cardiac complications
subject: Coronary artery stenosis
subject: Left atrial appendage occlusion
subject: NSTEMI
subject: 610.72

description: Closure of the left atrial appendage is a common procedure for patients with atrial fibrillation undergoing cardiac surgery. The technique of left atrial appendage occlusion (LAAO) by an extracardiac clip (AtriClip) is established as a reliable method. Acute coronary obstruction of the circumflex artery has already been described after minimally invasive LAAO. Here, we report a case of delayed circumflex artery obstruction after open‐heart surgery. A patient who had mitral and tricuspid valve surgery in combination with AtriClip implantation suffered from myocardial infarction 24 h after clip implantation. Cardiac catheterization showed that the circumflex artery was obstructed on the level of the AtriClip device. The stenosis was treated by percutaneous coronary intervention with stent implantation. In conclusion, the surgeon should consider placing the AtriClip device slightly far away from the base of the left atrial appendage to avoid coronary obstruction.
MPEC 2023-Q15 : 2023 QD
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 QD

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
FAK inhibition radiosensitizes pancreatic ductal adenocarcinoma cells in vitro
Creators: name: Mohamed, A. Allam
name: Thomsen, Andreas
name: Follo, Marie
name: Zamboglou, Costantinos
name: Bronsert, Peter
name: Mostafa, Hanan
name: Amen, Aber
name: Mekawy, Mohamed
name: Grosu, Anca-Ligia
name: Brunner, Thomas B.
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: Pancreatic ductal adenocarcinoma
subject: Focal adhesion kinase
subject: Radiosensitization
subject: Pancreatic stellate cell
subject: Microenvironment
subject: Stroma
subject: 610.72

description: Introduction Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase protein frequently overexpressed in cancer and has been linked to an increase in the stem cell population of tumors, resistance to therapy, and metastatic spread. Pharmacological FAK inhibition in pancreatic cancer has received increased attention over the last few years, either alone or in combination with other therapeutics including chemotherapy and immunotherapy. However, its prognostic value and its role in radioresistance of pancreatic ducal adenocarcinoma (PDAC) is unknown. Methods and materials Using the TCGA and GTEx databases, we investigated the genetic alterations and mRNA expression levels of PTK2 (the encoding-gene for FAK) in normal pancreatic tissue and pancreatic cancer and its impact on patient survival. Furthermore, we evaluated the expression of FAK and its tyrosine domain Ty-397 in three pancreatic cancer cell lines. We went further and evaluated the role of a commercial FAK tyrosine kinase inhibitor VS-4718 on the viability and radiosensitization of the pancreatic cell lines as well as its effect on the extracellular matrix (ECM) production from the pancreatic stellate cells. Furthermore, we tested the effect of combining radiation with VS-4718 in a three-dimensional (3D) multicellular pancreatic tumor spheroid model. Results A database analysis revealed a relevant increase in genetic alterations and mRNA expression of the PTK2 in PDAC, which were associated with lower progression-free survival. In vitro, there was only variation in the basal phosphorylation level of FAK in cell lines. VS-4718 radiosensitized pancreatic cell lines only in the presence of ECM-producing pancreatic stellate cells and markedly reduced the ECM production in the stromal cells. Finally, using a 3D multicellular tumor model, the combination of VS-4718 and radiotherapy significantly reduced the growth of tumor aggregates. Conclusion Pharmacological inhibition of FAK in pancreatic cancer could be a novel therapeutic strategy as our results show a radiosensitization effect of VS-4718 in vitro in a multicellular 2D- and in a 3D-model of pancreatic cancer.
Sechs Lieder : für eine Singstimme mit Begleitung des Klaviers oder der Guitarre : Werk 38
Creators: name: Amon, Johann Andreas
Publisher: name: Gombart'sche Musikhandlung
Year: 1806

description: Öffentliche Bibliothek der Universität Basel
description: Verzeichnung=Description=Inventaire 2009 Übernahme Rekatalogis. AK UB durch Medea 2002-2005
The Evolution of the Two Largest Tropical Ice Masses since the 1980s
Creators: name: Malone, Andrew
name: Broglie, Eleanor T
name: Wrightsman, Mary
Publisher: name: University of Illinois at Chicago
Year: 2023
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences
subject: Geophysics
subject: Earth sciences
subject: Physical geography and environmental geoscience
subject: Environmental engineering
subject: FOS: Environmental engineering
subject: Geomatic engineering

description: As tropical glaciers continue to retreat, we need accurate knowledge about where they are located, how large they are, and their retreat rates. Remote sensing data are invaluable for tracking these hard-to-reach glaciers. However, remotely identifying tropical glaciers is prone to misclassification errors due to ephemeral snow cover. We reevaluate the size and retreat rates of the two largest tropical ice masses, the Quelccaya Ice Cap (Peru) and Nevado Coropuna (Peru), using remote sensing data from the Landsat missions. To quantify their glacial extents more accurately, we expand the time window for our analysis beyond the dry season (austral winter), processing in total 529 Landsat scenes. We find that Landsat scenes from October, November, and December, which are after the dry season, better capture the glacial extent since ephemeral snow cover is minimized. We compare our findings to past studies of tropical glaciers, which have mainly analyzed scenes from the dry season. Our reevaluation finds that both tropical ice masses are smaller but retreating less rapidly than commonly reported. These findings have implications for these ice masses as sustained water resources for downstream communities.
Coronary vascular function in sleep and obstructive sleep apnoea
Creators: name: Hamilton., Garun Stuart
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Estimating mass-absorption cross-section of ambient black carbon aerosols: Theoretical, empirical, and machine learning models
Creators: name: Li, Hanyang
name: May, Andrew A.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Astronomical and Space Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: The mass-absorption cross-section of black carbon (MACBC) is an essential parameter to link the atmospheric concentration of black carbon (BC) with its radiative forcing. When a direct calculation of MACBC based on observations of aerosol light absorption and BC mass concentration is impossible, we rely on modeling and simulations to estimate MACBC, but currently, there is no consensus model that can be relied on for accurate predictions across all atmospheric environments when BC particles have different coating thicknesses. Here, we applied five MACBC prediction models (including three light scattering theories, an empirical model based on observations of particle mass concentrations, and a machine learning model developed in our previous work) to aerosols from three Department of Energy (DOE) Atmospheric Radiation Measurement (ARM) field campaigns. While many studies have found that increasing the complexity of the models helps to constrain biases of the estimated MACBC, our effort is to evaluate the models based on the criteria of simplicity and accuracy. We find that our machine learning model (support vector machine for regression, SVM) generally performs well across all DOE ARM field campaign data, while the accuracy of core-shell Mie theory depends on the bias correction algorithm applied to filter-based light absorption data. Generally, the empirical model for internally mixed particles that we considered tends to over-predict MACBC, while Mie theory for externally mixed particles tends to under-predict MACBC. An examination of the influence of coating material on BC cores suggests that the performance of our current SVM model is degraded when the BC is thickly coated (e.g., it has undergone aging and mixing with other materials in the atmosphere).
Inferring the evolutionary stages of the internal structures of NGC 7538 S and IRS1 from chemistry
Creators: name: Feng, S.
name: Beuther, H.
name: Semenov, D.
name: Henning, Th.
name: Linz, H.
name: Mills, E. A. C.
name: Teague, R.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: To unambiguously diagnose the detailed physical mechanisms and the evolutionary status of high-mass star-forming regions (HMSFRs), we have performed 0.4" ($\sim1000$ AU) resolution observations towards NGC7538S and IRS1, using the Plateau de Bure Interferometer (PdBI). This paper presents a joint analysis of the 1.37 mm continuum emission and the line intensity of 15 molecular species. Assuming local thermal equilibrium, we derived molecular column densities and molecular abundances for each internal gas substructure which is spatially resolved. These derived quantities are compared with a suite of 1-D gas-grain models. NGC7538S is resolved into at least three dense gas condensations. Despite the comparable continuum intensity of these condensations, their differing molecular line emission is suggestive of an overall chemical evolutionary trend from the northeast to the southeast. Since these condensations are embedded within the same parent gas core, their differing chemical properties are the most likely due to the different warm-up histories, rather than the different dynamic timescales. Despite remaining spatially unresolved, in IRS1 we detect abundant complex organic molecules, indicating that IRS1 is the most chemically evolved hot molecular core presented here. We observe a continuum that is dominated by absorption features with at least three strong emission lines, potentially from $\rm CH_3OH$. The $\rm CH_3OH$ lines which are purely in emission have higher excitation than the ones showing purely absorption. Potential reasons for that difference are discussed. This is the first comprehensive comparison of observations of the high-mass cores NGC7538S and IRS1 and a chemical model. We have found that different chemical evolutionary stages can coexist in the same natal gas core. Our achievement illustrates the strength of chemical analysis for understanding HMSFRs.
description: 34 pages, 10 figures, accepted by A&A
Assessing the difficulty of annotating medical data in crowdworking with help of experiments
Creators: name: Rother, Anne
name: Niemann, Uli
name: Hielscher, Tommy
name: Völzke, Henry
name: Ittermann, Till
name: Spiliopoulou, Myra
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: Crowdworking
subject: Healthcare-related data
subject: Annotation
subject: 000

description: Background As healthcare-related data proliferate, there is need to annotate them expertly for the purposes of personalized medicine. Crowdworking is an alternative to expensive expert labour. Annotation corresponds to diagnosis, so comparing unlabeled records to labeled ones seems more appropriate for crowdworkers without medical expertise. We modeled the comparison of a record to two other records as a triplet annotation task, and we conducted an experiment to investigate to what extend sensor-measured stress, task duration, uncertainty of the annotators and agreement among the annotators could predict annotation correctness. Materials and methods We conducted an annotation experiment on health data from a population-based study. The triplet annotation task was to decide whether an individual was more similar to a healthy one or to one with a given disorder. We used hepatic steatosis as example disorder, and described the individuals with 10 pre-selected characteristics related to this disorder. We recorded task duration, electro-dermal activity as stress indicator, and uncertainty as stated by the experiment participants (n = 29 non-experts and three experts) for 30 triplets. We built an Artificial Similarity-Based Annotator (ASBA) and compared its correctness and uncertainty to that of the experiment participants. Results We found no correlation between correctness and either of stated uncertainty, stress and task duration. Annotator agreement has not been predictive either. Notably, for some tasks, annotators agreed unanimously on an incorrect annotation. When controlling for Triplet ID, we identified significant correlations, indicating that correctness, stress levels and annotation duration depend on the task itself. Average correctness among the experiment participants was slightly lower than achieved by ASBA. Triplet annotation turned to be similarly difficult for experts as for non-experts. Conclusion Our lab experiment indicates that the task of triplet annotation must be prepared cautiously if delegated to crowdworkers. Neither certainty nor agreement among annotators should be assumed to imply correct annotation, because annotators may misjudge difficult tasks as easy and agree on incorrect annotations. Further research is needed to improve visualizations for complex tasks, to judiciously decide how much information to provide, Out-of-thelab experiments in crowdworker setting are needed to identify appropriate designs of a human-annotation task, and to assess under what circumstances non-human annotation should be preferred.
MPEC 2023-Q16 : 2023 QE
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 QE

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Additional file 1 of Local problem solving in the Portuguese health examination survey: a mixed method study
Creators: name: Lyshol, Heidi
name: Gil, Ana Paula
name: Tolonen, Hanna
name: Namorado, Sónia
name: Kislaya, Irina
name: Barreto, Marta
name: Antunes, Liliana
name: Gaio, Vânia
name: Santos, Ana João
name: Rodrigues, Ana Paula
name: Dias, Carlos Matias
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 1: Search terms.
title: Rekonstruktionen nach ausgedehnter ablativer Tumorchirurgie im Gesicht – Rückbesinnung auf bewährte Verfahren
Creators: name: Eckert, Alexander W.
name: Reich, Waldemar
name: Keschke, Claudia B.
name: Stuhlträger, Ute
Publisher: name: German Medical Science GMS Publishing House
Year: 2016
Subjects: subject: 610 Medical sciences; Medicine

description: Mittlerweile haben sich auch zum Verschluss von Defekten der Gesichtshaut mikrochirurgische Verfahren etabliert. Deren wesentlichen ästhetischen Einschränkungen sind die im Gesicht ungewohnte Textur und das veränderte Hautkolorit. Wir präsentieren 2 exemplarische Fälle ausgedehnter[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 53. Jahrestagung der Deutschen Gesellschaft für Plastische und Wiederherstellungschirurgie (DGPW)
Airborne murine coronavirus response to low levels of hypochlorous acid, hydrogen peroxide and glycol vapors
Creators: name: Gomez, Odessa
name: McCabe, Kevin M.
name: Biesiada, Emma
name: Volbers, Blaire
name: Kraus, Emily
name: Nieto-Caballero, Marina
name: Hernandez, Mark
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Geology
subject: FOS: Earth and related environmental sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Hematology

description: Airborne murine coronavirus was assessed for its sensitivity to the vapors of chemicals commonly used to disinfect indoor surfaces. As a model for the chemical sensitivity of airborne SARS-CoV-2, the infectious potential of airborne Mouse Hepatitis Virus (MHV) was tracked in the presence of the following pure chemical vapors, each of which was below its permissible exposure limit (PEL) as regulated by the US National Institute of Occupational Safety and Health (NIOSH): <50 ppmv for glycol; <1ppmv for HOCl; and <1ppmv for H2O2. Along with its growth media, infectious MHV was aerosolized in a particle size distribution between 0.5 μm and 3.2 μm into a sealed, dark, 9 m3 chamber maintained at 22°C and 60% RH, including levels of chemical vapors maintained below their respective PELs. As judged by the TCID50 of airborne MHV collected by condensation, this airborne virus was rapidly inactivated by HOCl vapor, incurring an average of 99% infectious potential loss after 16 ± 4 min exposure to ≤0.2 ppmv HOCl. Airborne MHV responded with a 99% loss of infectious potential in 38 ± 10 min of exposure to ≤0.9 ppmv H2O2; and, a 99% loss of infectious potential in 33 ± 15 min when exposed to a gas-phase dipropylene glycol blend ≤20 ppmv as TVOC. The juxtaposition of quantitative RT-PCR and TCID50 responses suggest that even low levels of gas-phase HOCl exposures can damage the genome of airborne coronavirus in relatively short time frames (c.a. <5 mins).
title: Harnleiterschienung nach unkomplizierter ureteroskopischer Steinextraktion: Eine Kosteneffizienzanalyse
Creators: name: Seklehner, S.
name: Kunit, T.
name: Engelhardt, P.F.
name: Riedl, C.
name: Sievert, K.-D.
Publisher: name: German Medical Science GMS Publishing House
Year: 2016
Subjects: subject: 610 Medical sciences; Medicine

description: Fragestellung: Die Notwendigkeit einer Harnleiterschienung nach unkomplizierter Ureteroskopie (URS) zur Steinsanierung wird kontrovers gesehen. Trotz gegenteiliger Literaturempfehlung wird sie oft routinemäßig durchgeführt. Der ökonomische Aspekt der Harnleiterschienung nach URS [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 42. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
Effective Hasse principle for the intersection of two quadrics
Creators: name: Quertier, Tony
Publisher: name: arXiv
Year: 2016
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11D09, 11Y50

description: We consider a smooth system of two homogeneous quadratic equations over the rationals in at least 13 variables. In this case, the Hasse principle is known to hold, thanks to the work of Mordell in 1959. The only local obstruction is over the reals. In this paper, we give an explicit algorithm to decide whether a nonzero rational solution exists, and if so, to compute one.
description: 14 pages
title: Gibt es in Deutschland saisonale Unterschiede bei Koliken von Kalziumoxalatsteinbildnern?
Creators: name: Nechita, M.
name: Düthorn, B.
name: Strohmaier, W.L.
Publisher: name: German Medical Science GMS Publishing House
Year: 2016
Subjects: subject: 610 Medical sciences; Medicine

description: Für viele Regionen der Erde wurden in den letzten Jahrzehnten saisonale Unterschiede im Auftreten von Koliken bei Harnsteinpatienten beschrieben. Teilweise bestehen auch Unterschiede zwischen einzelnen Steinarten. Ferner wurden für einzelne Jahreszeiten unterschiedliche steinrelevante Zusammensetzungen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 42. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
Unlocking further understanding of the atomization mechanism of a pressurized metered dose inhaler
Creators: name: Myatt, B. J.
name: Versteeg, H. K.
name: Hargrave, G. K.
name: Long, E. J.
name: Gavtash, B.
name: Lewis, D. A.
name: Church, T.
name: Brambilla, G.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Physical Sciences not elsewhere classified
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Marine Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Pressurized metered dose inhalers (pMDI) are one of the most common devices to deliver therapeutic treatment to patients with asthma or COPD. The atomization mechanism responsible for droplet production is poorly understood because of the short length and timescales involved, making experimental investigations to characterize fluid flow structures and spray formation processes difficult. This article reports the findings of new high-speed and high-resolution imaging and temperature measurements seeking to improve the fundamental understanding of the atomization mechanism of the pMDI. An annular flow regime of gaseous core in liquid annulus was observed in the orifice. Shock diamonds within the flow, viewed via Schlieren imaging, confirmed experimentally for the first time the choked nature of the orifice exit flow. Propellant formulation flow in the orifice was found to be superheated to a degree that significant flashing and evaporation at the orifice exit is likely to take place. This information points to a hybrid mechanism of predominantly aerodynamic atomization with significant liquid flashing upon exit from the orifice producing a near instantaneous formation of respirable droplets. Large irrespirable droplets are produced by two mechanisms; breakup of liquid slugs ejected from the orifice, due to unsteady transient fluid structures in the actuator sump and stripping of ligaments from a liquid pool around the orifice exit, which subsequently break up into large droplets in the periphery of the plume. This new understanding will aid development of next generation, high efficiency pMDIs, particularly those employing low global warming potential propellants such as HFA152a or HFO1234ze(E). Copyright © 2022 American Association for Aerosol Research
Analysis of repeated sequence elements in pathogenic Neisseria
Creators: name: Hamilton., Christopher William
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.