cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of A novel dual-prodrug carried by cyclodextrin inclusion complex for the targeting treatment of colon cancer
Creators: name: Chen, Lin
name: Lin, Yan
name: Zhang, Zijun
name: Yang, Ruisheng
name: Bai, Xiaosheng
name: Liu, Zhongbing
name: Luo, Zhongling
name: Zhou, Meiling
name: Zhong, Zhirong
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 1: Figure S1. Structural characterization of 2-hydroxy-5-butylamino benzoic acid. 1H-NMR spectra (A) and 13C-NMR spectra (B) of 2-hydroxy-5-butylamino benzoic acid in DMSO. Figure S2. Structural characterization of BBA. 1H-NMR spectra (A) and 13C-NMR spectra (B) of BBA in (CD3)2CO. Figure S3. Structural characterization of FA-PEG-CM-β-CD. 1H-NMR spectra of CM-β-CD (A), FA-PEG-NH2 (B), and FA-PEG-CM-β-CD (C). Fourier transform infrared spectra (D) of FA-PEG-CM-β-CD (a), mixture of FA-PEG-NH2 and CM-β-CD (b), FA-PEG-NH2 (c), and CM-β-CD (d). Figure S4. Particle size distribution of BBA/FA-PEG-CM-β-CD (DOCX 35712 KB)
title: Do pseudo-sands' internal structures determine biogeochemistry of tropicals' critical zone?
Creators: name: Kilian Salas, Simone
name: Schroeder, Paul A.
name: Woche, Susanne K.
name: Peth, Stephan
name: Boy, Jens
name: Guggenberger, Georg
name: Jungkunst, Hermann F.
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
Deeply weathered soils are iconic components of the tropical critical zone. Being short of exchangeable nutrients, physical features beyond sheer depth determine more than elsewhere the provision of life-sustaining resources. Biogeochemical models can hardly capture tropical fluxes, due to them being mainly developed and validated for temperate zones, focusing more on topsoil processes. To overcome this systematic bias, pedotransfer functions are regionally adapted for modeling soil water movements and then used for tropical biogeochemical modeling. However, soil texture based on single grain size distribution neglects the impact of actual soil structures in the field and leads to pronounced discrepancies between field measurements and model predictions for tropical soils. A prominent example of this mismatch is overestimated N2O emissions.

Now, scientific efforts are being made to correct this systematic bias in predicting soil functioning. A well-known characteristic of tropical soils, potentially responsible for the systematic error, are water-stable aggregates called pseudo-sands. In the field, they are perceived as sand, but in the lab measured as clay and silt. The simple assumption that pseudo-sands act just like sands in the field seems to work satisfactorily for certain hydrological predictions. We pursue the hypothesis that, biogeochemically, pseudo-sands do not simply act like sands. We provide evidences why pseudo-sands cannot be simply treated neither like “regular sand” nor like the sum of its units. The long-term goal is to develop tropical biogeochemical model versions related to the properties of pseudo-sands that will lead to improved models of the critical zone of the tropics.
title: Decimeter-scale hydraulic testing of pre-existing Fractures (HTPF) under anisotropic stress conditions. Part 2: Test procedure and results
Creators: name: Osten, Julian
name: Cadmus, Alexander
name: Jalali, Mohammadreza
name: Fuentes, Raul
name: Amann, Florian
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
To extract heat from tight deep subsurface formations, hydraulic stimulation is used to create efficient heat exchangers in the context of enhanced geothermal systems (EGS). Successful geothermal reservoir initiation requires detailed characterization of the regional in-situ stress field and local stress field variations of heterogeneous, i.e. fractured and faulted rock masses, which is often achieved by hydraulic fracturing (HT) and hydraulic testing of pre-existing fractures (HTPF).

To further develop and validate these field-scale in-situ stress determination techniques, decimeter laboratory scale HTPF tests into saw-cut and polished fracture planes are performed in a true triaxial testing apparatus (see Cadmus et al. 2023, this conference for details). Tests are carried out under various anisotropic stress boundary conditions to analyze normal opening and shear behavior. Results of two rock samples with different fracture roughness are analyzed and compared in terms of the injection pressure and flow rate evolution, shear displacement and acoustic emissions. The results indicate that both shear displacement and hydraulic jacking initiate as the injection pressure exceeds the fracture normal stress, which is attributed to heterogeneous fluid pressure distribution in the fracture plane. Future experiments on a fracture surface of intermediate roughness with additional observation boreholes aim to further assess the effects of fluid pressure distribution and fracture plane roughness in the context of stress measurement and induced seismicity.
Improving the login procedure to ORCID in DSpace(-CRIS) 7
Creators: name: Goldschmidt, Oliver
Publisher: name: TUHH Universitätsbibliothek
Year: 2023
Subjects: classificationCode: 004
subject: Informatik
classificationCode: 020
subject: Bibliotheks- und Informationswissenschaft

description: Folien des Kickoff-Treffens zum Projekt ORCID-Login. Das Projektvorhaben wird vorgestellt, die Problemstellung sowie die technischen Herausforderungen werden gezeigt. Ziel des Projektes ist eine Verbesserung des ORCID-Logins bei DSpace und DSpace-CRIS. Die Vorstellung fand am 09.02.2023 vor Vertreter*innen der ORCID Inc. statt.
description: Slides of the Kickoff-Meeting of the ORCID-Login project. The slides illustrate the project goals, the problem, that should be solved within the project and the technical challenges for that. Goal of the project is the improvement of the ORCID login on DSpace and DSpace-CRIS. The presentation was held on Feb-09, 2023 for staff members of ORCID Inc.
Offloading embedding lookups to processing-in-memory for deep learning recommender models
Creators: name: Zarif, Niloofar
Publisher: name: University of British Columbia
Year: 2023

description: Recommender systems are an essential part of many industries and businesses. Generating accurate recommendations is critical for user engagement and business revenue. Currently, deep learning recommender models are commonly used, but they face challenges in processing and representing categorical data, which is a significant portion of the data used by these models. Embedding layers are often used to handle these complications by storing the numerical representation of different categories of a feature in a reduced vector space. Vectors representing all the categories of a feature in the reduced vector space will be stored in a tabular structure named embedding table. The operation of fetching the vector representation of a category from the embedding table and pooling them is called embedding lookup. However, embedding lookups have large memory footprints and require high memory bandwidth, leading to high latency and low throughput. We have developed a new system called PIM-Rec to address these challenges by using the first commercially available Processing-In-Memory (PIM) capable DRAM modules for embedding lookups. PIM-Rec is the first system to use such DRAM modules, and it has shown an 80% decrease in end-to-end inference cycle latency and an 80% increase in latency-bound throughput compared to the standard CPU-only implementation. PIM DRAM modules are a good candidate for handling embedding lookups, especially with the recent drastic size increase of embedding tables. Although PIM-Rec faced obstacles, it offers a realistic solution and analysis while discovering the obstacles and projecting them. This new system provides a promising solution for improving the efficiency of recommender systems and reducing the load they incur in data centers.
Can Tanzania’s adaptation measures prevent future maize yield decline? A simulation study from Singida region
Creators: name: Volk, Johanna
name: Gornott, Christoph
name: Sieber, Stefan
name: Lana, Marcos Alberto
Publisher: name: Humboldt-Universität zu Berlin
Year: 2021
Subjects: subject: Maize
subject: Climate change
subject: Adaptation
subject: Model
subject: Tanzania
subject: NDC
subject: 330 Wirtschaft
subject: 550 Geowissenschaften
subject: 630 Landwirtschaft und verwandte Bereiche

description: Cereal crop production in sub-Saharan Africa has not achieved the much-needed increase in yields to foster economic development and food security. Maize yields in the region’s semi-arid agroecosystems are constrained by highly variable rainfall, which may be worsened by climate change. Thus, the Tanzanian government has prioritized agriculture as an adaptation sector in its intended nationally determined contribution, and crop management adjustments as a key investment area in its Agricultural Sector Development Programme. In this study, we investigated how future changes in maize yields under different climate scenarios can be countered by regional adjusted crop management and cultivar adaptation strategies. A crop model was used to simulate maize yields in the Singida region of Tanzania for the baseline period 1980–2012 and under three future climate projections for 2020–2060 and 2061–2099. Adaptation strategies to improve yields were full irrigation, deficit irrigation, mulch and nitrogen addition and another cultivar. According to our model results, increase in temperature is the main driver of future maize yield decline. Increased respiration and phenological development were associated with lower maize yields of 16% in 2020–2060 and 20% in 2061–2099 compared to the 1980–2012 baseline. Surprisingly, none of the management strategies significantly improved yields; however, a different maize variety that was tested as an alternative coping strategy performed better. This study suggests that investment in accessibility of improved varieties and investigation of maize traits that have the potential to perform well in a warmer future are better suited for sustaining maize production in the semi-arid region than adjustments in crop management.
Uptake and use of a minimum data set (MDS) for older people living and dying in care homes in England: a realist review protocol
Creators: name: Musa, Massirfufulay Kpehe
name: Akdur, Gizdem
name: Hanratty, Barbara
name: Kelly, Sarah
name: Gordon, Adam
name: Peryer, Guy
name: Spilsbury, Karen
name: Killett, Anne
name: Burton, Jennifer
name: Meyer, Julienne
name: Fortescue, Sue
name: Towers, Ann-Marie
name: Irvine, Lisa
name: Goodman, Claire
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: subject: Nursing
subject: FOS: Health sciences
subject: 1506
subject: 1715
subject: health services administration & management
subject: quality in health care
subject: palliative care
subject: public health
subject: epidemiology
subject: geriatric medicine

description: Introduction: Care homes provide nursing and social care for older people who can no longer live independently at home. In the UK, there is no consistent approach to how information about residents’ medical history, care needs and preferences are collected and shared. This limits opportunities to understand the care home population, have a systematic approach to assessment and documentation of care, identifiy care home residents at risk of deterioration and review care. Countries with standardised approaches to residents’ assessment, care planning and review (eg, minimum data sets (MDS)) use the data to understand the care home population, guide resource allocation, monitor services delivery and for research. The aim of this realist review is to develop a theory-driven understanding of how care home staff implement and use MDS to plan and deliver care of individual residents. Methods and analysis: A realist review will be conducted in three research stages. Stage 1 will scope the literature and develop candidate programme theories of what ensures effective uptake and sustained implementation of an MDS. Stage2 will test and refine these theories through further iterative searches of the evidence from the literature to establish how effective uptake of an MDS can be achieved. Stage 3 will consult with relevant stakeholders to test or refine the programme theory (theories) of how an MDS works at the resident level of care for different stakeholders and in what circumstances. Data synthesis will use realist logic to align data from each eligible article with possible context–mechanism–outcome configurations or specific elements that answer the research questions. Ethics and dissemination: The University of Hertfordshire Ethics Committee has approved this study (HSK/SF/UH/04169). Findings will be disseminated through briefings with stakeholders, conference presentations, a national consultation on the use of an MDS in UK long-term care settings, publications in peer-reviewed journals and in print and social media publications accessible to residents, relatives and care home staff. PROSPERO registration number: CRD42020171323; this review protocol is registered on the International Prospective Register of Systematic Reviews.
Inequalities in the uptake of, adherence to and effectiveness of behavioural weight management interventions: systematic review protocol
Creators: name: Birch, Jack Michael
name: Griffin, Simon J
name: Kelly, Michael P
name: Ahern, Amy L
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Public health
1506
1724
primary care
public health
preventive medicine

description: Introduction: It has been suggested that interventions focusing on individual behaviour change, such as behavioural weight management interventions, may exacerbate health inequalities. These intervention-generated inequalities may occur at different stages, including intervention uptake, adherence and effectiveness. We will synthesise evidence on how different measures of inequality moderate the uptake, adherence and effectiveness of behavioural weight management interventions in adults. Methods and analysis: We will update a previous systematic literature review from the United States Preventive Services Taskforce to identify trials of behavioural weight management interventions in adults aged 18 years and over that were, or could feasibly be, conducted in or recruited from primary care. Medline, Cochrane database (CENTRAL) and PsycINFO will be searched. Only randomised controlled trials (RCTs) and cluster-RCTs will be included. Two investigators will independently screen articles for eligibility and conduct risk of bias assessment. We will curate publication families for eligible trials. The PROGRESS-Plus acronym (place of residence, race/ethnicity, occupation, gender, religion, education, socioeconomic status, social capital, plus other discriminating factors) will be used to consider a comprehensive range of health inequalities. Data on trial uptake, intervention adherence, weight change and PROGRESS-Plus-related data will be extracted. Data will be synthesised narratively. We will present a Harvest plot for each PROGRESS-Plus criterion and whether each trial found a negative, positive or no health inequality gradient. We will also identify potential sources of unpublished original research data on these factors which can be synthesised through a future individual participant data meta-analysis. Ethics and dissemination: Ethical approval is not required as no primary data are being collected. The completed systematic review will be disseminated in a peer-reviewed journal, at conferences, and contribute to the lead author’s PhD thesis. Authors of trials included in the completed systematic review may be invited to collaborate on a future individual participant data meta-analysis. PROSPERO registration number: CRD42020173242.
title: Kinematics and rifting processes of the Liguro-Provençal Basin, Western Mediterranean
Creators: name: Jensen, Alex
name: Le Breton, Eline
name: Brune, Sascha
name: Dannowski, Anke
name: Lange, Dietrich
name: Murray-Bergquist, Louisa
name: Kopp, Heidrun
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
The Liguro-Provençal Basin, situated at the junction of the Northern Apennines and the Western Alps, formed due to the rollback subduction of the Adriatic-African plate underneath Europe and the subsequent upper plate extension in the Oligocene to early Miocene time. The opening of this basin was accompanied by the counter-clockwise rotation of the Corsica-Sardinia block relative to Europe until 16 Ma, with the basin widening towards southwest. It is yet unclear if the extension ever reached seafloor spreading with the production of oceanic crust, or whether it led to anomalously thin continental crust and/or to mantle exhumation. Although considered as tectonically inactive today, the Liguro-Provençal Basin shows active seismicity, indicating compression and potential basin inversion. Thus, it is crucial to better understand the opening of the basin and the tectonic inheritance due to rifting in order to better interpret the present-day seismicity. To this end, we compile existing geological and geophysical data, including recent data from the 4DMB project (“Mountain Building Processes in Four Dimensions”), to constrain the crustal and sedimentary thicknesses throughout the basin. We also focus specifically on two profiles in the NE (Corsica-Provence) and SW (Sardinia-Gulf of Lion) parts of the basin and compare these with the results of coupled thermo-mechanical and surface process modelling using Aspect and Fastscape codes. Finally, we discuss the effect of differences in various parameters, such as pre-rift crustal thickness, rift velocities and sediment supply, on rifting processes in the Liguro-Provençal Basin.
Depression in patients with spondyloarthritis: prevalence, incidence, risk factors, mechanisms and management
Creators: name: Parkinson, Joel T.
name: Foley, Éimear M.
name: Jadon, Deepak R.
name: Khandaker, Golam M.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Extra-articular manifestations and comorbidities in spondyloarthritis
ankylosing spondylitis
assessment
depression
depressive disorder
epidemiology
psoriatic arthritis
spondyloarthritis
treatment

description: Funder: MQ: Transforming Mental Health; FundRef: https://doi.org/10.13039/501100008162; Grant(s): MQDS17/40
description: Funder: cambridge trust; FundRef: https://doi.org/10.13039/501100003343
description: Depression is a major neuropsychiatric disorder common in patients with rheumatological conditions including spondyloarthritis (SpA). It is associated with higher disease activity, functional impairment, poor treatment response and quality of life in patients with musculoskeletal disorders. Using ankylosing spondylitis (AS) and psoriatic arthritis (PsA) as examples, we have reviewed the evidence regarding the burden, risk factors, potential mechanisms and clinical management of depression in spondyloarthritis. The prevalence of depression is higher in patients with AS and PsA compared with the general population, with evidence of moderate/severe depression in about 15% of patients with AS or PsA. Mild depression is even more common and estimated to be present in about 40% of patients with AS. In addition to conventional risk factors such as stressful life events and socioeconomic deprivation, increased risk of depression in SpA may be associated with disease-related factors, such as disease activity, poor quality of life, fatigue, and sleep disturbances. Emerging evidence implicates inflammation in the aetiology of depression, which could also be a shared mechanism for depression and chronic inflammatory conditions such as AS and PsA. It is imperative for clinicians to actively assess and treat depression in SpA, as this could improve treatment adherence, quality of life, and overall long-term clinical and occupational outcomes. The use of validated tools can aid recognition and management of depression in rheumatology clinics. Management of depression in SpA, especially when to refer to specialist mental health services, are discussed.
Galaxy formation and evolution in the era of Euclid
Creators: name: Pozzetti, Lucia
Publisher: name: Zenodo
Year: 2021
Subjects: Synergies with wavelengths and facilities

description: The Space Mission Euclid will collect light from distant cosmic objects with its 1.2-metre mirror telescope that is designed to work at both visible and near-infrared wavelengths. Euclid’s mission is to measure the shapes of more than a billion galaxies, and the accurate redshifts of tens of millions of galaxies across more than one third of the sky. It allows us to investigate the nature of dark matter and dark energy by accurate measurements of both the accelerated expansion of the Universe and the strength of gravity on cosmological scales. Besides its primary science cosmological goal the mission will map out the large-scale structure of the Universe across 10 Gyr. I will review the enourmous value of the Euclid's dataset to study galaxy and AGN evolution, from primordial universe to local galaxies. Euclid data, indeed, will provide imaging with resolution 3 orders of magnitude higher than before, to allow an accurate derivation of structural, physical and evolutionary quantities of galaxies and AGNs and their associated dark matter haloes. Euclid forecasts for galaxy & AGN evolution as well as the expected performances for the Euclid Wide and Deep surveys will be presented, along with the most important Euclid key projectson galaxy formation and evolution.
Kaiser Family Foundation Poll: LGBTQ Rights and Health Care
Creators: name: Kaiser Family Foundation
Publisher: name: Roper Center for Public Opinion Research
Year: 2021

description: Discrimination against racial groups (4); discrimination against LGBT people (4); societal acceptance of transgender people (1); discrimination against disabled people (1); legality of discrimination against LGBT people (5); Trump administration role removing non-discrimination rules against LGBT people in healthcare (1); Supreme Court ruling prohibiting employers from employment discrimination against LGBT people (1); know anyone who is transgender (1).
title: Isotope hydrogeochemistry and physico-chemistry of Lago Enriquillo (Dominican Republic) and its tributaries
Creators: name: Berndt, Christopher
name: Böttcher, Michael Ernst
name: Haberzettl, Torsten
name: Biedermann, Lilly
name: Matias Marte de Reyes, Berenice
name: Garcia Cocco, Edwin
name: Wrozyna, Claudia
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
Tropical cyclones (TCs) such as hurricanes are amongst the most devastating natural disasters of the modern world causing massive humanitarian, ecological, and economic damage every year. A better understanding of timing and frequency of TCs must, therefore, be a key priority for building resilience of affected countries. Within this project, we investigate a stable isotope-based approach for the reconstruction of paleo-TCs through the integration of ecological and morphological data with isotope geochemical signatures of modern ostracodes in relation to the hydrochemistry from a tropical lake located within the Main Development Region of TCs (Lago Enriquillo, Dominican Republic). Water samples were taken during two seasons in 2022 on different vertical profiles through the lake, associated tributaries and closed-by water bodies. Besides in-situ characterization, samples were taken for major, minor, and trace elements using different analytical approaches, and the stable isotope signatures of water (2H, 18O; CRDS spectroscopy), dissolved inorganic carbon (13C; gas mass spectrometry), and sulfate (34S, 18O; gas mass spectrometry). Hydrochemical data were further evaluated using the speciation model PHREEQC.

Substantial changes in the lake composition were observed between the two campaigns. Together with an evaluation of element stoichiometries, the water isotopes allow for an evaluation of sources and evapotranspiration. Carbon and sulfur isotopes allow to deduce the role of microbial activity and solution-atmosphere exchange on the modulation of the dissolved carbon system, in contact with solid phase carbonates, like ostracod shells
Levels of domain-specific physical activity at work, in the household, for travel and for leisure among 327 789 adults from 104 countries
Creators: name: Strain, Tessa
name: Wijndaele, Katrien
name: Garcia, Leandro
name: Cowan, Melanie
name: Guthold, Regina
name: Brage, Soren
name: Bull, Fiona C
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Original research
1506
2314
physical activity
surveillance
epidemiology

description: Objective: To compare the country-level absolute and relative contributions of physical activity at work and in the household, for travel, and during leisure-time to total moderate-to-vigorous physical activity (MVPA). Methods: We used data collected between 2002 and 2019 from 327 789 participants across 104 countries and territories (n=24 low, n=34 lower-middle, n=30 upper-middle, n=16 high-income) from all six World Health Organization (WHO) regions. We calculated mean min/week of work/household, travel and leisure MVPA and compared their relative contributions to total MVPA using Global Physical Activity Questionnaire data. We compared patterns by country, sex and age group (25–44 and 45–64 years). Results: Mean MVPA in work/household, travel and leisure domains across the 104 countries was 950 (IQR 618–1198), 327 (190–405) and 104 (51–131) min/week, respectively. Corresponding relative contributions to total MVPA were 52% (IQR 44%–63%), 36% (25%–45%) and 12% (4%–15%), respectively. Work/household was the highest contributor in 80 countries; travel in 23; leisure in just one. In both absolute and relative terms, low-income countries tended to show higher work/household (1233 min/week, 57%) and lower leisure MVPA levels (72 min/week, 4%). Travel MVPA duration was higher in low-income countries but there was no obvious pattern in the relative contributions. Women tended to have relatively less work/household and more travel MVPA; age groups were generally similar. Conclusion: In the largest domain-specific physical activity study to date, we found considerable country-level variation in how MVPA is accumulated. Such information is essential to inform national and global policy and future investments to provide opportunities to be active, accounting for country context.
Rana occipitalis Gu. 1758
Creators: name: Müller, F
Publisher: name: Zenodo
Year: 1885
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Amphibia
Anura
Ranidae
Rana
Rana occipitalis

description: Rana occipitalis Gü.
Tumbo-Insel v. H. Mich. Müller. [3]
description: Published as part of Müller, F, 1885, Vierter Nachtrag zum Katalogder herpetologischen Sammlung des Basler Museums, pp. 668-717 in Verhandlungen der Naturforschenden Gesellschaft in Basel. 7 (3) on page 670, DOI: 10.5962/bhl.part.2388, http://zenodo.org/record/15183591
Azathioprine immunosuppression and disease modification in Parkinson’s disease (AZA-PD): a randomised double-blind placebo-controlled phase II trial protocol
Creators: name: Greenland, Julia C
name: Cutting, Emma
name: Kadyan, Sonakshi
name: Bond, Simon
name: Chhabra, Anita
name: Williams-Gray, Caroline H
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Neurology
1506
1713
Parkinson's disease
therapeutics
immunology

description: Introduction: The immune system is implicated in the aetiology and progression of Parkinson’s disease (PD). Inflammation and immune activation occur both in the brain and in the periphery, and a proinflammatory cytokine profile is associated with more rapid clinical progression. Furthermore, the risk of developing PD is related to genetic variation in immune-related genes and reduced by the use of immunosuppressant medication. We are therefore conducting a ‘proof of concept’ trial of azathioprine, an immunosuppressant medication, to investigate whether suppressing the peripheral immune system has a disease-modifying effect in PD. Methods and analysis: AZA-PD is a phase II randomised placebo-controlled double-blind trial in early PD. Sixty participants, with clinical markers indicating an elevated risk of disease progression and no inflammatory or immune comorbidity, will be treated (azathioprine:placebo, 1:1) for 12 months, with a further 6-month follow-up. The primary outcome is the change in the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale gait/axial score in the OFF state over the 12-month treatment period. Exploratory outcomes include additional measures of motor and cognitive function, non-motor symptoms and quality of life. In addition, peripheral and central immune markers will be investigated through analysis of blood, cerebrospinal fluid and PK-11195 positron emission tomography imaging. Ethics and dissemination: The study was approved by the London-Westminster research ethics committee (reference 19/LO/1705) and has been accepted by the Medicines and Healthcare products Regulatory Agency (MHRA) for a clinical trials authorisation (reference CTA 12854/0248/001–0001). In addition, approval has been granted from the Administration of Radioactive Substances Advisory Committee. The results of this trial will be disseminated through publication in scientific journals and presentation at national and international conferences, and a lay summary will be available on our website. Trial registration numbers: ISRCTN14616801 and EudraCT- 2018-003089-14.
Optimization of log logistics at the operational level considering sorting decisions and synchronization requirements
Creators: name: Ghotb, Seyed Salar
Publisher: name: University of British Columbia
Year: 2023

description: Log logistics activities, such as transporting, loading/unloading, and processing of logs, are essential elements of forest operations and account for a significant portion of the total costs of delivered logs. Although previous studies investigated log logistics, they mainly emphasized on economic aspects and did not address some practical aspects of the logistics problem. The main goal of this dissertation is to optimize log logistics at the operational level incorporating practical considerations and complexities. In order to achieve this goal, a decomposition framework is employed that divides the log logistics problem into two phases. In the first phase, a bi-objective optimization model is developed in which sorting decisions, trucking contractors, and compatibility requirements at supply and demand locations are considered. The first objective of the bi-objective model is to minimize the total transportation costs, while the second objective addresses the social aspects by balancing the workload of contractors. The outputs of the first phase are used as the inputs of the second phase, for which an optimization model is developed to determine the daily routing and scheduling of heterogeneous trucks using continuous time representation. The model enables synchronization of log loaders and trucks and generates a detailed schedule of activities. In addition, a solution approach based on the simulated annealing algorithm is developed to solve the large-sized daily routing and scheduling problem. The Taguchi method is used to enhance the quality of the solutions by calibrating the input parameters of the algorithm. The framework, optimization models, and the solution approach are applied to a case study of a large Canadian forest company where logs are transported from cut blocks to sort yards for further processing. Results show that the framework can generate balanced workloads for all contractors with less than 1% increase in transportation costs and can determine the daily schedule of log trucks considering practical operational considerations. It is concluded that assigning overtime to trucks instead of dispatching a new truck can generate cost savings. The proposed models and the solution approach can be applied to other cases and regions by modifying the input data.
Exploring the potential for introducing home monitoring of blood pressure during pregnancy into maternity care: current views and experiences of staff—a qualitative study
Creators: name: Hinton, Lisa
name: Hodgkinson, James
name: Tucker, Katherine L
name: Rozmovits, Linda
name: Chappell, Lucy
name: Greenfield, Sheila
name: McCourt, Christine
name: Sandall, Jane
name: McManus, Richard J
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Obstetrics and gynaecology
1506
hypertension
organisation of health services
maternal medicine
qualitative research

description: Objective: One in 20 women are affected by pre-eclampsia, a major cause of maternal and perinatal morbidity, death and premature birth worldwide. Diagnosis is made from monitoring blood pressure (BP) and urine and symptoms at antenatal visits after 20 weeks of pregnancy. There are no randomised data from contemporary trials to guide the efficacy of self-monitoring of BP (SMBP) in pregnancy. We explored the perspectives of maternity staff to understand the context and health system challenges to introducing and implementing SMBP in maternity care, ahead of undertaking a trial. Design: Exploratory study using a qualitative approach. Setting: Eight hospitals, English National Health Service. Participants: Obstetricians, community and hospital midwives, pharmacists, trainee doctors (n=147). Methods: Semi-structured interviews with site research team members and clinicians, interviews and focus group discussions. Rapid content and thematic analysis undertaken. Results: The main themes to emerge around SMBP include (1) different BP changes in pregnancy, (2) reliability and accuracy of BP monitoring, (3) anticipated impact of SMBP on women, (4) anticipated impact of SMBP on the antenatal care system, (5) caution, uncertainty and evidence, (6) concerns over action/inaction and patient safety. Conclusions: The potential impact of SMBP on maternity services is profound although nuanced. While introducing SMBP does not reduce the responsibility clinicians have for women’s health, it may enhance the responsibilities and agency of pregnant women, and introduces a new set of relationships into maternity care. This is a new space for reconfiguration of roles, mutual expectations and the relationships between and responsibilities of healthcare providers and women. Trial registration number: NCT03334149.
title: A Technical Approach to 3D Modelling of the Subsurface Geology in the South-Eastern Harz Foreland
Creators: name: Jeske, Tilman J.
name: Siegburg, Melanie
name: Malz, Alexander
name: Müller, Olaf-Christian
name: Rappsilber, Ivo
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
The digitization of geological data is becoming increasingly important in the assessment of the subsurface geology, and 3D visualization offers new possibilities. To extend the visualization of the subsurface geology of the State of Saxony-Anhalt, a 3D structural model of Permian to Quaternary stratigraphy of the South-Eastern Harz Foreland has been created. The model is based on pre-existing data consisting of maps from large-scale subsurface exploration, seismic profiles, and c. 5,660 stratigraphic profiles from the extensive borehole database from over 100 years of drilling exploration. Data preparation consisted of extracting borehole data, digitizing and vectorizing maps and seismic profiles, and subsequent processing with ArcGIS. Modelling of the surface mesh of stratigraphic boundaries and faults was performed using SKUA-GOCAD 22 in the 'Structure and Stratigraphy' workflow. In this iterative process, inconsistencies in the topology and geometry of the mesh have to be resolved manually in several steps in order to create a consistent model. Challenges arise from low data density in some areas and conflicting information in data from different sources. The resulting model shows the arrangement and relationship of stratigraphic units and major faults of the area in a refined level of detail. Within the requirements of publication and provision of state geological data by the Geological Survey of Saxony-Anhalt (LAGB), the model was prepared to be published via the GST (Geosciences in Space and Time) framework at the LAGB.
Supplementary Materials from Eight-year periodical outbreaks of the train millipede
Creators: name: Niijima, Keiko
name: Momoka Nii
name: Yoshimura, Jin
Publisher: name: The Royal Society
Year: 2021
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60301 Animal Systematics and Taxonomy
subject: 60310 Plant Systematics and Taxonomy
subject: 60801 Animal Behaviour

description: Periodical cicadas are the only confirmed periodical animals with long life cycles. In Japan, however, 8-year periodicity had been suggested in a species of train millipedes that had frequently obstructed trains in the central mountainous region of Honshu, Japan. This species was identified as Parafontaria laminata armigera Verhoeff (Diplopoda: Xystodesmidae), which is endemic to Japan. We finally confirmed the 8-year periodicity of this millipede using detailed surveys of life histories over 8 years. Seven broods were recognized, with almost no overlaps in their distributions. We also report the historical outbreaks and train obstructions of this millipede during 1920–2016. This is the first confirmed case of periodical non-insect arthropods.
Map #438, Site 5MT10647, Pithouse 231, Surface 1 and Nonstructure 242, Surface 1
Creators: name: DeVos, Jim
Year: 2018
Subjects: subject: Southwestern Colorado
valueUri: https://core.tdar.org/browse/geographic-keyword/2810/southwestern-colorado
subject: Southwestern US
valueUri: https://core.tdar.org/browse/geographic-keyword/84604/southwestern-us
subject: Basketmaker III
valueUri: https://core.tdar.org/browse/temporal-keyword/78/basketmaker-iii
subject: Pueblo I
valueUri: https://core.tdar.org/browse/temporal-keyword/54/pueblo-i
subject: Pueblo II
valueUri: https://core.tdar.org/browse/temporal-keyword/55/pueblo-ii
subject: 5MT10647
valueUri: https://core.tdar.org/browse/site-name/118013/5mt10647
subject: Dillard Site
valueUri: https://core.tdar.org/browse/site-name/118012/dillard-site

description: Site 5MT10647, Pithouse 231, Surface 1 and Nonstructure 242, Surface 1
title: 3D geological modelling of the surficial aquitards in the German “Central Oder” sub-catchment.
Creators: name: Duscher, Klaus
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
The „Central Oder“ sub-catchment in Germany is the first of three areas for which structural models of the surficial aquitards down to the latest Elsterian till are being constructed as part of the Geo3D-Oder project. All other areas are interpreted as undifferentiated aquifers. The data base is taken from the "Lithofacies map of the Quaternary 1 : 50,000" (LKQ 50).

The model consists of ten stratigraphic layers, each bounded by a top and base horizon, and the ground surface. The data combines polygons defining the extent of the strata and point data of elevations derived from contour lines and stratigraphic logs. The data was processed and transferred to the SKUA-GOCAD modelling platform.

The geological 3D model contains only a concordant sequence of horizons with no faults. The challenge in constructing 3D models of Quaternary glacial sediments lies in the variable and sometimes very small layer thickness. Especially in the case of unavailable information on the elevation of upper horizons, layers below cannot be correctly reproduced. A new method has been developed to avoid this. For each horizon, the uppermost proven elevations of all underlying strata were identified in search quadrants. This data was used to interpolate 'virtual horizons', which are constraints on the maximum depth for each horizon. The resulting horizons were finalised using automated routines and manual post-processing.
Map #389, Site 5MT10647, Great Kiva 102, Surface 1 and Features 17, 22, 26 and 27, Surface 2
Creators: name: DeVos, Jim
Year: 2018
Subjects: subject: Southwestern Colorado
valueUri: https://core.tdar.org/browse/geographic-keyword/2810/southwestern-colorado
subject: Southwestern US
valueUri: https://core.tdar.org/browse/geographic-keyword/84604/southwestern-us
subject: Basketmaker III
valueUri: https://core.tdar.org/browse/temporal-keyword/78/basketmaker-iii
subject: Pueblo I
valueUri: https://core.tdar.org/browse/temporal-keyword/54/pueblo-i
subject: Pueblo II
valueUri: https://core.tdar.org/browse/temporal-keyword/55/pueblo-ii
subject: 5MT10647
valueUri: https://core.tdar.org/browse/site-name/118013/5mt10647
subject: Dillard Site
valueUri: https://core.tdar.org/browse/site-name/118012/dillard-site

description: Site 5MT10647, Great Kiva 102, Surface 1 and Features 17, 22, 26 and 27, Surface 2
title:   Discussions and Creations: Experiences of Black Music Therapy Graduate Students Building Community and Belonging
Creators: name: Spann, Rebekah I.
Publisher: name: University of Kentucky Libraries
Year: 2023
Subjects: classificationCode: 6.4
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: There is currently a lack of racial diversity within the music therapy field and a lack of research on the experiences of Black music therapy graduate students wanting to build community and belonging. The purpose of this study was to understand the experiences of three Black graduate music therapy students at the University of Kentucky seeking to build community and belonging with their Black peers. To further understand the experiences of these Black graduate music therapy students, this study followed participatory action research (PAR) methodology. Throughout the research process, I worked with participants to shape the project in a way that best fit the needs of everyone involved. Throughout our weekly group meetings, the researcher and participants discussed topics related to current events and personal experiences related to our individual feelings of Blackness. Data was collected via a focus group interview, completed at the end of the weekly group meetings. The data from this interview was analyzed through verbatim transcription and coding, with the researcher identifying similar themes throughout the interview. Three themes emerged from the data: are these my people, we are not alone in this, and continuing to build community and future possibilities. These themes led to a community building experience, providing suggestions for other Black college students and music therapy educators who work with these students throughout the academic year.
description: © 2023 Rebekah Irene Spann
Three-year review of a capacity building pilot for a sustainable regional network on food, nutrition and health systems education in India
Creators: name: Buckner, Luke
name: Carter, Harrison
name: Ahankari, Anand
name: Banerjee, Rinku
name: Bhar, Somnath
name: Bhat, Shivani
name: Bhattacharya, Yagnaseni
name: Chakraborty, Debashis
name: Douglas, Pauline
name: Fitzpatrick, Laura
name: Maitra-Nag, Sudeshna
name: Muhkerjee, Sagarika
name: Ray, Sabyasachi
name: Roy, Ananya
name: Saha, Aparjita
name: Sayegh, Marietta
name: Rajput-Ray, Minha
name: Tsimpli, Ianthi
name: Ray, Sumantra
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Original research
1506
2523
dietary patterns
malnutrition
nutrient deficiencies

description: Background: In Kolkata (India), there are high rates of malnourished children (45.9%) under the age of three, impacting growth, organ development, function, and cognition. Mothers have a major role to play during this crucial development stage, with research showing nutrition knowledge, attitudes and practices (KAP) of mothers are important determinants of childhood malnutrition. Aims: To document 3 years of capacity building towards a sustainable nutrition education network in Kolkata, India, while assessing the ability to perform data collection in the form of needs assessments, impact assessments and capacity reviews. Methods: Descriptive review and analysis of engagement and impact from 3 years of work by the NNEdPro Global Centre for Nutrition and Health, initiating locally led nutrition education interventions. Mapping to the Indian National Nutrition Strategy was also performed to review adherence to nationwide priorities surrounding nutrition and determine the wider application potential of the network. Results: Two simultaneous projects were taken forward by a team of local healthcare professionals and student champions. Project 1—medical college workshops for medical student nutrition education with added focus on underserved populations, Project 2—preparation for a ‘Mobile Teaching Kitchen’ (MTK) in marginalised communities to empower local women as nutrition educators. Data collection methods used for analysing markers of impact and sustainability were semi-structured interviews of the community members, and KAP questionnaires to assess response to educational sessions. Conclusion: With local support it is possible to create and sustain fieldwork for an extended period with meaningful outputs and impact. This initiative demonstrates that it is possible to use healthcare professionals, students and volunteers with low-intensity training and a low-cost approach to produce action research with considerable impact and results in rapid, reliable and robust manner.
title: Characteristics and inhibition of microbial induced corrosion and biofilm formation by thermal shocks under in-situ conditions in a geothermal heat-storage plant in Neubrandenburg (Germany)
Creators: name: Otten, Christoph
name: Teitz, Sebastian
name: Lienen, Tobias
name: Kleyböcker, Anne
name: Würdemann, Hilke
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2023

description:
Geothermal facilities in the North German Basin are frequently affected by corrosion and scaling due to high salinity as well as microbial induced corrosion. To study biofilm formation, corrosion processes and countermeasures, a mobile bypass system was installed at the Neubrandenburg geothermal heat storage plant. The reservoir was located in a depth of 1300m in a saline aquifer (~130g/L NaCl). Operation was conducted in two different seasonal modes. In the warm months, heat was stored, while in the winter months the direction of flow was reversed and heat was recovered. At temperatures lower than 60°C, at the cold side of the aquifer, corrosion was promoted by microbial activity, which led to the formation of biofilms on plant components and pipes. Biofilms consisted mainly of various genera of fermentative, sulfate reducing and hydrogen consuming bacteria. Longer incubation time as well as inoculation with fresh biofilm showed an independency of seasonal mode and enrichment of highly adapted community composition with the dominating sulfate-reducing genus Desulfallas.

As a countermeasure to corrosion, heat shocks were evaluated in the bypass system and tested also two times at the large scale plant. Heat shocks led to significantly reduced biofilm formation on corrosion coupons and correspondingly reduced iron sulfide precipitates and corrosion rates from 0.538mm/a to 0.170mm/a over an observation period of 48 days. The impact of one heat shock lasted for more than four weeks. Overall the use of periodic heat shocks showed its preventative measure against microbial induced corrosion and scaling in geothermal plants.