cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The study of cell motility and plasticity in cancer: the role of the crosstalk between BM-MSCs and tumor in osteosarcoma progression and Claisened Hexafluoro as potential inhibitor of amoeboid motility in metastatic melanoma
Creators: name: LEO, ANGELA
Publisher: name: Universit� degli Studi di Siena
Year: 2021

description: Part 1
Growing evidence suggest that bone marrow-derived mesenchymal stem cells (BM-MSCs) are key players in tumor stroma. Here, we investigated the cross-talk between BM-MSCs and osteosarcoma (OS) cells in tumor progression.
We revealed a strong tropism of BM-MSCs towards these tumor cells and identified monocyte chemoattractant protein (MCP)-1, growth-regulated oncogene (GRO)-? and transforming growth factor (TGF)-?1 as pivotal factors for BM-MSC chemotaxis. Once in contact with OS cells, BM-MSCs trans-differentiate into cancer-associated fibroblasts, further increasing MCP-1, GRO-?, interleukin (IL)-6 and IL-8 levels in the tumor microenvironment. These cytokines promote mesenchymal to amoeboid transition (MAT), driven by activation of the small GTPase RhoA, in OS cells, as illustrated by the in vitro assay and live imaging.
The outcome is a significant increase of aggressiveness in OS cells in terms of motility, invasiveness and trans-endothelial migration. In keeping with their enhanced trans-endothelial migration abilities, OS cells stimulated by BM-MSCs also sustain migration and invasion. Thus, BM-MSC recruitment to the OS site and the consequent cytokine-induced MAT are crucial events in OS malignancy.
Part 2
Metastatic melanoma is one of the most aggressive and lethal malignancies with a poor prognosis. Melanoma cells are able to migrate using different types of cell motility such as the rounded/amoeboid-type motility and the elongated/mesenchymal-type motility thanks to their high plasticity. Really several data underline the crucial role of amoeboid motility in the dissemination process of highly metastatic melanoma cells. Thus, targeting this process could be a promising strategy to prevent the metastatic spreading of melanoma cells.
Claisened Hexafluoro is a chemical analog of Honokiol (HKL), a biphenolic compound derived from Magnolia officinalis which has antitumoral and antimetastatic effect in numerous cancers, including melanoma.
Starting from these evidence, here we tested Claisened Hexafluoro on human metastatic melanoma cells, as an inhibitor of amoeboid motility. Data here reported demonstrate that Claisened Hexafluoro, impairing mitochondrial activity and affecting AMP-activated protein kinase (AMPK) signaling, strongly inhibits amoeboid motility and many steps of the disseminating process in vitro as well as in vivo, confirming its possible future application to fight metastatic spreading of melanoma cells.
CELLULOSE BASED THERMOCHROMIC SMART WINDOW SYSTEM
Creators: name: Aranke, Sai Swapneel
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Mechanical engineering not elsewhere classified

description: Smart windows that modulate solar radiation by changing their optical state in response to temperature stimulus are developing as promising solutions towards reducing the energy consumption of buildings. The market adoption of such systems has been slow due to the barriers in scalability, cost, as well as complexity in their integration into existing systems. Aiming these features, we have proposed a retrofit smart window design based on the temperature-responsive polymer Methyl Cellulose (MC). The system utilizes a sustainable, earth abundant and cost-effective cellulose based thermo-responsive material to transform existing windows to a thermally dynamic smart window system. The observed optical change of MC from transparent to opaque state is dependent on temperature and is triggered by the thermodynamic mechanism of reversible coil-globule transition, which results in a stable performance of the proposed device. Its solar modulation ability was studied using ultraviolet-visible- spectroscopy. Effect of MC concentration and various salts on the optical performance were investigated. It was found that the transition temperature the polymer can be tuned by varying MC concentration and by adding salts to the system. The tunability of transition temperature is a function of the concentration of salt and the type of anion in the salt. It was observed that the transition temperature of the window can be tuned between to , allowing a wide range of control over switching temperature. Controllable LCST, low freezing point, sustainable base material, scalable production, low cost, retrofit system makes them ideal candidates for smart window applications.
Functional proteomic investigation of extracellular vesicles: Rai +/+ vs Rai -/- astrocytes and released vesicles in EAE and bronchoalveolar lavage fluid-extracted extracellular vesicles in idiopathic pulmonary fibrosis
Creators: name: SHABA, ENXHI
Publisher: name: Universit� degli Studi di Siena
Year: 2021

description: In the recent years, extracellular vesicles (EVs) drew a growing interest in scientific community, especially for their intrinsic role of cell-cell communication entities between local and distant targets. Given these appealing features, functional proteomics of EVs is a considerably valuable approach for the investigation of not only their functions, but also of their potentialities, as it provides a wider and enriched scenario of various physio-pathological molecular mechanisms. Considering this background, we performed two different functional proteomic studies on EVs in two different pathologic conditions.
The first study emerged from recent investigations on protein ShcC/Rai role in experimental autoimmune encephalomyelitis (EAE), as its deficiency resulted in disease protection and astrocytes were identified as accountable for the establishment of a local protective environment. Therefore, our analysis focused on the differences in protein content of astrocytes, as well as of their released extracellular vesicles, between Rai+/+ and Rai -/- in a not stimulated and IL-17-stimulated conditions, applying 2DE, image analysis, mass spectrometry identification of differential proteins and enrichment analysis. Curiously, our proteomic data showed that both the vesicular and cellular differential proteins indicate the overall involvement of macro molecular areas, such as oxidative stress response, ECM and cellular remodelling, glutamate metabolism, EMT mechanisms and metabolic reprogramming, shifting astrocytes towards a neuroprotective response.
Concurrently, a second study was conducted to characterize and explore the individual impact on Idiopathic Pulmonary Fibrosis (IPF) pathogenesis of not only the vesicular component of bronchoalveolar lavage fluid (BALF), but also its fluid counterpart. Indeed, to the best of our knowledge, our study is the first shotgun proteomic investigation of EV isolated from BALF of IPF patients. To this purpose, ultracentrifugation was chosen as EVs isolation technique and its purification was assessed by TEM, 2DE and LC-MS/MS. Interestingly, our 2DE data and scatter plot analysis showed a considerable difference of EVs proteome with respect to whole BALF and to its fluid counterpart proteome, highlighting the importance of pre-fractioning of complex samples to the advantage of low-abundant protein species in biomarkers discovery. Remarkably, enrichment analysis results draw attention on a systemic metabolic dysregulation in disease development and highlight relevant molecular pathways that result distinctive but complementary in IPF pathogenesis.
Investigation of PT symmetry breaking and exceptional points in delay-coupled semiconductor lasers
Creators: name: Wilkey, Andrew Ryan
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Lasers and quantum electronics
Foundations of quantum mechanics

description: This research investigates characteristics of PT (parity-time) symmetry breaking in a system of two optically-coupled, time-delayed semiconductor lasers. A theoretical rate equation model for the lasers’ electric fields is presented and then reduced to a 2x2 Hamiltonian model, which, in the absence of time-delay, is PT-symmetric. The important parameters we control are the temporal separation of the lasers (τ), the frequency detuning (∆ω), and the coupling strength (κ). The detuning is experimentally controlled by varying the lasers’ temperatures, and intensity vs. ∆ωbehavior are examined, specifically how the PT-transition and the period and amplitude of sideband intensity oscillations change withκandτ. Experiments are compared to analytic predictions and numerical results, and all are found to be in good agreement. Eigenvalues, eigenvectors, and exceptional points of the reduced Hamiltonian model are numerically and analytically investigated, specifically how nonzero delay affects existing exceptional points.
SNAI1 target genes in myoblasts
Creators: name: ELIA, INES
Publisher: name: Universit� degli Studi di Siena
Year: 2021

description: SNAI proteins are zinc finger transcription factors that act as transcriptional repressors through a conserved domain (SNAG domain) located in the N-terminus of the protein. These factors bind to a palindromic sequence of the E-box group (CANNTG) in the regulatory regions of their target genes. The role of SNAI11 and SNAI2 is well known in the epithelial mesenchymal transition, where they act as regulators increasing the capacity of tumor cells to metastasize. Less is known about their role as mediators in tissue homeostasis and differentiation. Recent studies have showed SNAI1 and SNAI2 as repressors of muscle differentiation, with the function of maintaining myoblasts in an undifferentiated state during the proliferative phase.
In this study, we explored the function of SNAI1 and SNAI2 in myogenesis both in vitro and in vivo. In vitro, we analyzed the expression of SNAI1 and SNAI2 in proliferating murine myoblasts, at various time points after inducing their differentiation. To evaluate their expression during myogenesis in vivo, we induced skeletal muscle regeneration by injecting the myotoxic agent Bupivacaine in the tibialis anterior muscles of wild-type and transgenic mice. We demonstrated that SNAI1 and SNAI2 are upregulated in proliferating myoblasts both in vitro and in vivo.
Through the analysis of the transcriptome in C2C12 myoblasts silenced for the expression of SNAI1, we have identified several target genes, among which Fgf21 and Atf3. FGF21 is a growth factor involved in muscle differentiation as well as in glucose and lipid metabolism. In muscle differentiation, FGF21 expression is increased during myogenic differentiation and its knockdown impairs myogenic differentiation in C2C12 cells. ATF3 is a transcription factor that induces endoplasmic reticulum stress (ER-stress), phenomenon behind numerous physiological processes, including muscle differentiation and metabolism regulation. Recent studies have showed that ATF3 is able to regulate chemokine mRNA expression in C2C12 myotubes and it attenuates inflammation of skeletal muscle upon muscle-damaging eccentric exercise.
Herein, we analyzed the direct involvement of SNAI1 in the regulation of Fgf21 and Atf3.
For this purpose, several Fgf21 and Atf3 promoter deletion mutants, cloned in front of the reporter gene for luciferase, were generated in order to progressively exclude the possible binding sites for SNAI1. We used the Dual-Luciferase Reporter Assay System and ChIP-qPCR analysis to demonstrate that SNAI1 directly binds to the promoter region of Fgf21 and Atf3, leading to the activation of Fgf21 and Atf3 expression in mouse C2C12 myoblasts.
Finally, we generated a SNAI1 knockout C2C12 cell line, using the CRISPR-Cas9 genome editing technique and we confirmed that SNAI1 acts as repressor of Fgf21 and Atf3 in proliferating myoblasts.
DEFINING DEVELOPMENTAL TOXICITY OF THE AGRICULTURAL HERBICIDE ATRAZINE IN THE EXPOSED AND SUBSEQUENT GENERATIONS USING ZEBRAFISH
Creators: name: Tai, Janiel K Ahkin Chin
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Dental therapeutics, pharmacology and toxicology

description: Atrazine (ATZ) is an agricultural herbicide. The US Environmental Protection Agency has set the maximum contaminant level at 3 μg/l in potable water, though concentrations can greatly exceed this amount depending on the time of year. Epidemiological studies report associations with developmental health outcomes with potable water exposure. Studies in model organisms identify ATZ as a neurotoxicant and endocrine disrupting chemical. The zebrafish model system was used to test the hypothesis that developmental ATZ exposure has immediate health consequences as well as in the subsequent generation. It was first hypothesized that developmental ATZ exposure generates metabolites similar to those found in mammals and alters morphology and behavior in larvae. In the exposed generation, targeted metabolomic analysis found that zebrafish produce the same major ATZ metabolites as mammals. The visual motor response test at 120 hpf detected hyperactivity in larvae in the 0.3 ppb treatment group and hypoactivity in the 30 ppb treatment group. These findings suggest that developmental ATZ exposure generates metabolite profiles similar to mammals leading to behavioral alterations supporting ATZ as a neurodevelopmental toxicant. In the subsequent generation (F1), it was hypothesized that parental ATZ exposure altered protein expression leading to modifications in morphology and behavior in developing progeny. Proteomic analysis identified differential expression associated with neurological development and disease and organ and organismal morphology, specifically the skeletomuscular system. Head length and the ratio of head length to total length was significantly increased in the F1 in the 0.3 and 30 ppb ATZ treated groups. Craniofacial morphology was assessed based on molecular pathway analysis and revealed decreased cartilaginous structure size, decreased surface area and distance between saccular otoliths, and a more posteriorly positioned notochord, indicating delayed ossification. The visual motor response assay showed hyperactivity in the F1 of the 30 ppb treatment group for total distance and time spent moving in the F1 of the 0.3 and 30 ppb treatment groups for all phases. Collectively, these results demonstrate persistent ATZ developmental toxicity in this multigeneration study.
Tumor progression: new targets and nutraceutical approaches
Creators: name: ERCOLI, JASMINE
Publisher: name: Universit� degli Studi di Siena
Year: 2021

description: Cancer development is a complicated and multistep process that drives the progressive transformation of normal human cells into highly malignant derivatives through genetic alterations. Successive mutations in oncogenes and tumor-suppressor genes virtually result in enhanced proliferation and resistance to cell death. These genes play a central role in the genesis and progression of human cancers, as their frequent alterations have been found in a variety of human cancers. Furthermore, inflammation is a key component of the tumor microenvironment that acts as a key regulator of tumor promotion and progression by several mechanisms.
Due to the complexity of the numerous pathways involved in cancer progression and the increasingly frequent onset of the phenomenon of resistance to anticancer drugs in some tumors, current research focuses on discover of new targets and new approaches for cancer treatment.
In this work, we analysed two key objectives of cancer research: anticancer activity of natural compounds and identification of new possible molecular targets for therapy and diagnosis.
In the first part of the work we studied the effects of two different natural compounds/extracts on cellular pathways altered in cancer. In particular, we evaluated the activity of oat-derivatives, the Avenanthramides, on cell proliferation, migration and EMT, focusing on EGFR signalling pathway, and the antioxidant, antinflammatory and antiproliferative effects of an extract of a rare variety of common bean (Phaseolus Vulgaris L. Var Venanzio) growth in South of Tuscany.
In the second part of the work we studied the involvement in cancer of KRIT1, a protein known for its involvement in Cerebral Cavernous Malformation (CCM), a rare vascular disease typically found in the central nervous system. As KRIT1 in CCM induces characteristic similar to cancer including loss of cell junctions, improvement of migration and proliferation and new vessel formation, a tumor-suppressor like behaviour of KRIT1 has been hypothesized. Starting from this hypothesis, we first performed a bio-bank data analysis to find a correlation between KRIT1 and cancer and then we evaluated the expression levels of KRIT1 in human cancer specimens and its function in cancer cell lines.
Taken together the data of this work contribute to increase the knowledge on the molecular mechanisms underlying the anticancer activities of two different natural derivatives and describe a new molecular pathway involved in cancer progression, thus providing scientific support for future therapies and new possible targets in the treatment of cancer.
sj-doc-1-taj-10.1177_20406223211046685 – Supplemental material for Impact of previous biologic use and body weight on the effectiveness of guselkumab in moderate-to-severe plaque psoriasis: a real-world practice
Creators: name: Hung, Yi-Teng
name: Lin, Yu-Jr
name: Chiu, Hsien-Yi
name: Huang, Yu-Huei
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Cardiology
subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: 110308 Geriatrics and Gerontology
subject: 110904 Neurology and Neuromuscular Diseases
subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: 110203 Respiratory Diseases

description: Supplemental material, sj-doc-1-taj-10.1177_20406223211046685 for Impact of previous biologic use and body weight on the effectiveness of guselkumab in moderate-to-severe plaque psoriasis: a real-world practice by Yi-Teng Hung, Yu-Jr Lin, Hsien-Yi Chiu and Yu-Huei Huang in Therapeutic Advances in Chronic Disease
Unraveling tandem repeat variation in personal genomes with long reads
Creators: name: BOLOGNINI, DAVIDE
Publisher: name: Universit� degli Studi di Siena
Year: 2021

description: Tandem repeats are repeated sequences that occur adjacent to each other in the human genome.
Due to their prevalence and their association with a number of genetic diseases, there is a rising
interest in developing tools for tandem repeat profiling. Genome-wide discovery approaches are
needed to fully understand their roles in health and disease but resolving tandem repeat variation
accurately remains a very challenging task. Indeed, while traditional mapping-based and
assembly-based approaches using short-read data have severe limitations in the size and type of
tandem repeats they can resolve, recent third-generation sequencing technologies provide the
long reads required to broaden the scope of detectable tandem repeats but exhibit substantially
higher sequencing error rates that complicates repeat resolution.
In order to overcome limitations of prior methods, we developed TRiCoLOR, a freely-available tool
for tandem repeat profiling using error-prone long reads from third-generation sequencing
technologies. The method can identify repetitive regions in long-read sequencing data de novo
and resolve their motif and multiplicity in a haplotype-specific manner. The tool further includes
methods to interactively visualize the identified repeats and to trace their Mendelian consistency
in pedigrees. Tested on synthetic data harboring tandem repeat contractions and expansions,
TRiCoLOR demonstrates excellent performances and improved precision and recall compared to
alternative tools. For real human whole-genome sequencing data, TRiCoLOR achieves high
validation rates, suggesting its suitability to identify tandem repeat variation in personal genomes.
Compared to assembly-based approaches for structural variant detection, TRiCoLOR
demonstrates capable to resolve tandem repeats in difficult to assemble regions that are prone to
mis-assemblies or incorrect repeat assignments.
TRiCoLOR is open-source and implemented in python 3, with supporting C++ code and bash
scripts. The tool is released through GitHub https://github.com/davidebolo1993/TRiCoLOR and
as a docker image https://hub.docker.com/r/davidebolo1993/tricolor, with accompanying
documentation.
Phase diagram of the SU($N$) antiferromagnet of spin $S$ on a square lattice
Creators: name: Schwab, Jonas
name: Toldin, Francesco Parisen
name: Assaad, Fakher F.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We investigate the ground state phase diagram of an SU($N$)-symmetric antiferromagnetic spin model on a square lattice where each site hosts an irreducible representation of SU($N$) described by a square Young tableau of $N/2$ rows and $2S$ columns. We show that negative sign free fermion Monte Carlo simulations can be carried out for this class of quantum magnets at any $S$ and even values of $N$. In the large-$N$ limit, the saddle point approximation favors a four-fold degenerate valence bond solid phase. In the large $S$-limit, the semi-classical approximation points to Néel state. On a line set by $N=8S + 2$ in the $S$ versus $N$ phase diagram, we observe a variety of phases proximate to the Néel state. At $S = 1/2$ and $3/2$ we observe the aforementioned four fold degenerate valence bond solid state. At $S=1$ a two fold degenerate spin nematic state in which the C$_4$ lattice symmetry is broken down to C$_2$ emerges. Finally at $S=2$ we observe a unique ground state that pertains to a two-dimensional version of the Affleck-Kennedy-Lieb-Tasaki state. For our specific realization, this symmetry protected topological state is characterized by an SU(18), $S=1/2$ boundary state, that has a dimerized ground state. These phases that are proximate to the Néel state are consistent with the notion of monopole condensation of the antiferromagnetic order parameter. In particular one expects spin disordered states with degeneracy set by $\text{mod}(4,2S)$.
description: 18 pages, 21 figures; adapted title to APS style and included minor corrections
Bitter taste receptors: new players in female and male fertility
Creators: name: SEMPLICI, BIANCA
Publisher: name: Universit� degli Studi di Siena
Year: 2021

description: The mammalian taste perception provides valuable information about the nature and quality of food.
Taste transduction involves the interaction of molecules (i.e. tastants) with taste receptor (TASRs)
whose expression isn?t limited to the oral cavity; indeed, many studies showed how these receptors
can be found also in extraoral location, wherein their function appears less obvious and remains to be
understood in most cases.
The expression of these receptors outspreads also to brain, respiratory tract, urinary bladder and testis,
where some of these receptors are expressed in different stages of spermatogenesis. Moreover, the
expression of selected member of different receptor families in ejaculated human sperm has been
reported. These findings suggest a possible involvement of TASRs in sperm maturation as well as in
sperm chemotactic activation and fertilization.
To the best of our knowledge, no data are available regarding the expression of TASRs in the
mammalian oocyte nor in the somatic cells of the follicle.
Therefore, to investigate the possible role of TASRs in male and female reproductive system,
focusing on their impact on human fertility, we analyzed the expression of some members of taste 2
receptors family (TAS2Rs) genes in human germ cells and follicular cells, namely granulosa and
cumulus cells. The expression of genes involved in taste receptors signaling cascade was also
investigated, both in female and male. Immunofluorescence analysis and western blot of TAS2Rs
and related signaling pathways also carried out highlighting the expression of selected TAS2Rs genes
in ejaculated sperm and in testis and, for the first time, in somatic cells from human ovarian follicle.
An interesting finding of this thesis work is the demonstration of TAS2R14 as the most expressed
gene in both granulosa and cumulus cells. These results suggest a key role of this receptor and also
for its potential involvement in follicular cells physiology. The possible role of this receptor in
reproduction is also supported by a study showed TAS2R14 to be correlated with sperm progressive
motility.
In order to elaborate an enrichment analysis to summarize functional information about the
investigated proteins and to predict possible associations among them, a protein network analysis was
performed by MetaCore software.
Even if further studies are needed to better understand the precise functional role oftaste receptors in
reproduction, this work try to improve our knowledge of the biological role of TAS2Rs for human
male and female fertility.
sj-docx-1-smx-10.1177_00811750211046307 – Supplemental material for What Goes Up Might Not Come Down: Modeling Directional Asymmetry with Large-N, Large-T Data
Creators: name: Thombs, Ryan P.
name: Huang, Xiaorui
name: Fitzgerald, Jared Berry
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology
subject: Sociology

description: Supplemental material, sj-docx-1-smx-10.1177_00811750211046307 for What Goes Up Might Not Come Down: Modeling Directional Asymmetry with Large-N, Large-T Data by Ryan P. Thombs, Xiaorui Huang and Jared Berry Fitzgerald in Sociological Methodology
KENGAYTIRILGAN BORLIQ VA UNING TURLARI. KENGAYTIRILGAN BORLIQNING QOʻLLANILISHI
Creators: name: Qodirov, Farrux
name: Rahmatullayova, Aziza
Publisher: name: Zenodo
Year: 2025

description: Kengaytirilgan borliq (AR) - bu haqiqiy dunyo bilan raqamli ma’lumotlarni birlashtiruvchi interaktiv texnologiya bo‘lib, u foydalanuvchilarga yangi tajribalar va imkoniyatlar yaratadi. Maqolada kengaytirilgan borliqning asosiy turlari, jumladan, AR tizimlari, ilovalar va qurilmalar ko‘rib chiqiladi. Shuningdek, maqola AR texnologiyasining turli sohalardagi qo‘llanilishi – ta’limda, sog‘liqni saqlashda, sanoatda va ko‘ngilochar sohalarda qanday foyda keltirishi haqida muhokama olib boradi. Kengaytirilgan borliqning ijtimoiy-iqtisodiy ta’siri ham yoritilib, uning kelajakdagi rivojlanish istiqbollari haqida fikrlar bildiradi. Mavzuning asosiy maqsadi kengaytirilgan borliqning mohiyatini tushuntirish va uning imkoniyatlarini keng jamoatchilikka yetkazishdir. Ushbu tadqiqot natijalari nafaqat ilmiy jamoatchilik uchun, balki amaliyotchi mutaxassislar uchun ham qimmatli bo‘lishi kutilmoqda. Kengaytirilgan borliqning chuqur tahlili orqali o‘qituvchilar, tadqiqotchilar va innovatsion mutaxassislar yangi yondoshuvlarni ishlab chiqishlari mumkin.
sj-docx-1-cos-10.1177_00207152211041385 – Supplemental material for Between-country inequalities in health lifestyles
Creators: name: VanHeuvelen, Tom
name: VanHeuvelen, Jane S
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Sociology
subject: FOS: Sociology

description: Supplemental material, sj-docx-1-cos-10.1177_00207152211041385 for Between-country inequalities in health lifestyles by Tom VanHeuvelen and Jane S VanHeuvelen in International Journal of Comparative Sociology
sj-pdf-1-teu-10.1177_13548166211035853 – Supplemental Material for The impact of ownership and size heterogeneity on hotel efficiency in the Canary Islands (Spain)
Creators: name: Pérez-Rodríguez, Jorge Vicente
name: Acosta-González, Eduardo
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Economics
subject: 150402 Hospitality Management
subject: FOS: Economics and business

description: Supplemental Material, sj-pdf-1-teu-10.1177_13548166211035853 for The impact of ownership and size heterogeneity on hotel efficiency in the Canary Islands (Spain) by Jorge Vicente Pérez-Rodríguez and Eduardo Acosta-González in Tourism Economics
sj-pdf-1-asp-10.1177_00037028211045424 - Supplemental material for Up-Conversion Luminescence Processes in NaLaF4 Doped with Tm3+ and Yb3+ and Dependence on Tm3+ Concentration and Temperature
Creators: name: Grube, Jurgis
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies

description: Supplemental material, sj-pdf-1-asp-10.1177_00037028211045424 for Up-Conversion Luminescence Processes in NaLaF4 Doped with Tm3+ and Yb3+ and Dependence on Tm3+ Concentration and Temperature by Jurgis Grube: on behalf of the ChiOTEAF Registry Investigators in Applied Spectroscopy
sj-docx-1-tar-10.1177_17534666211037454 – Supplemental material for A new protocol for exercise testing in COPD; improved prediction algorithm for WMAX and validation of the endurance test in a placebo-controlled double bronchodilator study
Creators: name: Tufvesson, Ellen
name: Radner, Finn
name: Simonsen, Anton
name: Papapostolou, Georgia
name: Jarenbäck, Linnea
name: Jönsson, Saga
name: Nihlen, Ulf
name: Tunsäter, Alf
name: Ankerst, Jaro
name: Peterson, Stefan
name: Bjermer, Leif
name: Eriksson, Göran
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine
subject: 110203 Respiratory Diseases

description: Supplemental material, sj-docx-1-tar-10.1177_17534666211037454 for A new protocol for exercise testing in COPD; improved prediction algorithm for WMAX and validation of the endurance test in a placebo-controlled double bronchodilator study by Ellen Tufvesson, Finn Radner, Anton Simonsen, Georgia Papapostolou, Linnea Jarenbäck, Saga Jönsson, Ulf Nihlen, Alf Tunsäter, Jaro Ankerst, Stefan Peterson, Leif Bjermer and Göran Eriksson in Therapeutic Advances in Respiratory Disease
ESSAYS ON MONEY AND CREDIT IN MACROECONOMICS
Creators: name: ULUG, MEHMET
Publisher: name: Universit� degli Studi di Siena
Year: 2021

description: The thesis consists of three independent chapters on the role of endogenous money on shadow banking and international ?nance. In the ?rst chapter (Endogenous Money, Eurodollar, and the Shadow Banking System), I examine the consequence of endogenous money for banks and shadow banks at both the national and international level by considering the importance that the Eurodollar market played in the emergence of shadow banking. In the second chapter (The shadow banking system in a stock-?ow consistent framework), I develop an SFC model that includes complex ?nancial markets and important components of the shadow banking sector, which enables us to explore the relationship between core commercial banks and shadow banks. Building a complete ?nancial sector and its interaction with the real sectors within an SFC framework allowed us to shed light on the role that shadow banking plays in the origination of credit. In the third chapter (Repo lending and its implications for the central bank monetary policy and government debt issues), I examine the transformation of money markets over the past four decades and the implications of this transformation for the implementation of monetary policy and government debt issues.
title: A Case Study Of How
Nursing Students Learn
Clinical Decision-Making In
Practice Placements
Creators: name: Mitchell, Joanna
Publisher: name: London South Bank University
Year: 2015

description: decision-making is a crucial component of being a health care
professional and is essential for a registered nurse. Therefore it is a key
competence for nursing students to achieve during their pre-registration
programme. There is a dearth of research about how nursing students learn
clinical decision-making in practice, and most of the previous studies sought
students’ opinions about their practice learning.
The aim of the research was to explore how nursing students learn to make
clinical decisions in practice placements and the influences that affect
learning clinical decision-making in practice placements. Using Yin’s (2009)
case study approach, the thesis explored the influences on first and third year
nursing students learning of clinical decision-making on a female medical
ward in a hospital. Ethical approval was obtained. A complex consent process
included students, mentors, ward staff and patients, prior to data collection.
Six students’ learning in practice was observed on two occasions each (n=12)
and they were interviewed at the time of the observations about their learning
of clinical decision-making (n=12). Mentors supporting the students’ learning
were also interviewed (n=4) and students’ practice assessment documents
analysed (n=4). The data was analysed using Richie and Spencer’s (1994)
framework approach.
The findings showed that the ward’s community approach to supporting
students’ learning enhanced their experience and supported the learning of
clinical decision-making. Ensuring patient safety and delivery of dignified
compassionate care was paramount through role modelled behaviour and
safe supervision. A structured approach to learning clinical decision-making
was evident by mentors and students, who were highly motivated and
demonstrated a heutagogical approach (Hase and Kenyon 2000) to their
learning.
First and third year students were supported differently by mentors with third
year students having close supervision to enable them to make clinical decisions about higher risk patients. First year students were sometimes in
decision-making situations that caused them anxiety. Students needed to be
self-regulating in their decision-making, seeking support from other staff when
decisions might compromise patient safety.
Synthesis of the findings with established tools informed the generation of a
proposed framework to support students’ learning clinical decision-making
and to facilitate their mentors supporting their learning in the future. The study
has brought new understanding to the subject of learning clinical decisionmaking
through real life evidence from observation of students and mentors in
practice placements.
Undergraduate engineering student misconception regarding complex circuits: The case with solid-state device circuits
Creators: name: Perez, Rene Alexander A Soto
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Electrical engineering not elsewhere classified
Education assessment and evaluation

description: Undergraduate engineering students usually face difficulties understanding electric circuit concepts. Some of those difficulties regard with misconceptions students bring into the classroom and develop during the learning process. Additionally, the increasing complexity of the topics along the fundamental electric circuits course constitutes another factor to those difficulties students experience. Another component we can add to this equation consists of the need of modernize and actualize the curriculum to meet the society’s demands of the next taskforce. Therefore, it is important to investigate the conceptual difficulties students experience when they analyze complex electric circuits. In this dissertation, I identify what those conceptual difficulties are when undergraduate sophomore engineering students attempt to analyze solid-state device circuits. The context of this research comprises a modernized version of the traditional fundamental electric circuits course. This modernized version includes DC analysis, 1st order transient analysis, AC, and solid-state device analysis. This dissertation took the form of three individual but complementary studies. Each study contributes to partially answer the overall research question. However, each study answered its own research problem. The first study attempted for identifying what concepts beginning students find challenging regarding semiconductors physics, diodes, and transistors. The second study identified student’s misconceptions when they analyze two solid-state device circuits, one with a diode, and the other with a transistor. The final study looked for determining what misconceptions students use at both earlier and more advances stages along the course. This study also searched for understanding how students move through conceptual changes along the semester. The general findings comprise three main points. First, students bring misconceptions into the classroom probably built from their previous experiences. Second, they also can develop those misconceptions through the learning process. This is particularly key regarding the relatively new and complex topics from student’s perspectives. Finally, language plays an important role on the kind of misconceptions students develop. How students perceive the professional community use language contributes to either consolidate or modify old misconceptions or develop new ones.
Three Essays on Grading Policies, Student Mobility and University-to-Work Transition
Creators: name: LOMBARDI, GABRIELE
Publisher: name: Universit� degli Studi di Siena
Year: 2020

description: This Thesis uses administrative data in order to investigate some crucial issues about Italian Student Population such as internal mobility with a particular focus to South-North Migration; freshmen performance in STEM area and School-to-Work Transition. The analysis are based on two novel datasets and they benefit of three different modelling techniques in order to appropriately explore the three research questions.
MILLIY TAOMDAN GLOBAL TRENDGACHA
Creators: name: Ilhomova Nozima O'zDJTU Sharq filologiya fakulteti FYAP 2410- guruh talabasi
Publisher: name: Zenodo
Year: 2025

description: Ushbu maqolada Yaponiya milliy va taniqli taomi — sushining kelib chiqishi hamda uning butun dunyoda mashhur bo‘lish sabablari tahlil qilinadi. Shuningdek, sushi tayyorlash va iste’mol qilish madaniyati, uning turli xalqlarga moslashuvi, bu taomning xalqaro sahnadagi o‘rni va global taom madaniyatiga ta’siri haqida fikr yuritiladi. Sushi taomining nafaqat yapon oshxonasidagi, balki xalqaro miqyosdagi ahamiyati haqida yoritilgan.
La tradizione manoscritta del "Livre du gouvernement des roys et des princes" di Henri de Gauchy. Studio filologico e saggio di edizione
Creators: name: SCALA, GAVINO
Publisher: name: Universit� degli Studi di Siena
Year: 2021

description: La presente tesi di dottorato si pone l?obiettivo di riaggiornare gli studi sulla tradizione manoscritta del Livre du gouvernement des roys et des princes, la prima traduzione francese del De regimine principum di Egidio Romano, trattato didattico-morale ascrivibile al genere degli specula principis, incentrato sull?educazione e sulla formazione del principe e composto dal teologo agostiniano intorno al 1277-80 su commissione del re di Francia, Filippo III detto l?Ardito. Indirizzato al figlio e successore al trono, Filippo IV il Bello, il De regimine principum condensa in tre libri l?Etica, l?Economica e la Politica di Aristotele, spesso mutuate dal commento di Tommaso d?Aquino. Pertanto, oltre alla rilevanza politica, tale trattato rappresenta anche una tappa fondamentale nel processo di trasmissione del pensiero aristotelico. L?importanza storico-letteraria del De regimine principum fu probabilmente percepita gi� all?epoca tanto che lo stesso re di Francia, Filippo III, ne ordina una traduzione in francese, eseguita nel 1282 da Henri de Gauchy, canonico di San Martino di Liegi, operante alla corte di Francia.
La tradizione manoscritta di questa prima traduzione francese � l?oggetto della presente tesi. Nel corso del primo capitolo del presente lavoro si illustrano i risultati ottenuti in seguito alle operazioni di recensio e collatio del testimoniale, che ad oggi ammonta a 39 testimoni. Sulla base di una serie di loci critici e dopo aver raggruppato famiglie, gruppi e sottogruppi, si � quindi tracciato uno stemma codicum, che non solo ha permesso di approfondire le questioni riguardanti la diffusione del testo, ma anche di stabilire nuovi criteri di edizione in modo da superare la datata (ed unica) edizione del Gouvernement, pubblicata dallo studioso statunitense Samuel Paul Molenaer nel 1899 e basata sul solo codice N.
Nel secondo capitolo si � dato spazio alla descrizione codicologica dei singoli testimoni mentre nel terzo capitolo � stato contestualizzato il Gouvernement da un punto di vista storico-letterario, chiarendo prima di tutto il rapporto tra fonte e volgarizzamento.
Nuovi criteri di edizione sono quindi alla base del saggio di edizione proposto, il cui obiettivo � quello di restituire un testo quanto pi� prossimo all?originale, ma anche di rappresentare diacronicamente la tradizione. Si � infatti dato spazio anche al testo critico di una selezione di capitoli delle due redazioni alternative del testo (z e ?) e del capitolo latino che riaffiora in un sottogruppo della tradizione.
In appendice, infine, si presenta il testo critico, corredato da un parziale studio delle fonti, delle interpolazioni proprie della redazione z, che tra le altre particolarit� macro-strutturali, amalgama nel testo del Gouvernement materiali provenienti da altre tradizioni.
Study of Transition on a Flared Cone with Forced Direct Numerical Simulation
Creators: name: Shuck, Andrew James
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Aerospace engineering not elsewhere classified

description: High speed boundary layers are an important aspect of vehicle design. It is crucial to know whether the boundary layer is laminar, turbulent, or transitional. The heat transfer rate increases dramatically from laminar to turbulent flow, so it must be considered when designing a high speed vehicle. This thesis studied a flared cone geometry with forced direct numerical simulation. This geometry has experimental data collected from a Mach 6 quiet tunnel and previous computational data. A two stage computational procedure is carried out in order to efficiently model the boundary layer. The first stage involved finding a full cone solution and creating an inlet profile. This inlet profile is imposed on the inlet of a 10-degree sector of the flared cone. This is done to achieve the desired resolution while maintaining reasonable computational costs for the DNS. With this setup, the second stage continues with a high-order basic state computation using the inlet profile. After the higher order basic state is computed, random forcing is applied using traveling plane waves to promote transition and the results are analyzed. Linear stability and frequency analysis is conducted and the unstable frequencies match with expected results. Transition is achieved using the forcing and qualitatively matches previous experimental and computational data for the flared cone. Just as in the experiment and previous computations, regions of primary and secondary streaks are found and have similar heat transfer magnitudes. However, the location of these streaks is different and is likely due to the setup of the computation.
Supplemental Material, sj-doc-4-apc-10.1177_23742895211041725 - Enhancing the Pipeline of Pathologists in the United States
Creators: name: Naritoku, Wesley Y.
name: Furlong, Mary A.
name: Knollman-Ritschel, Barbara
name: Kaul, Karen L.
Publisher: name: SAGE Journals
Year: 2021
Subjects: Medicine

description: Supplemental Material, sj-doc-4-apc-10.1177_23742895211041725 for Enhancing the Pipeline of Pathologists in the United States by Wesley Y. Naritoku, Mary A. Furlong, Barbara Knollman-Ritschel and Karen L. Kaul in Academic Pathology
Sintesi e caratterizzazione di nuovi derivati della creatina per la terapia del deficit del trasportatore SLC6A8 e nuova procedura sintetica per l'ottenimento della fosfocreatina
Creators: name: ARKEL, MARIA
Publisher: name: Universit� degli studi di Genova
Year: 2018

description: Parte 1
Il Deficit del trasportatore della creatina � una rara malattia genetica dovuta al malfunzionamento della proteina denominata SLC6A8 e deputata al trasporto della creatina attraverso le barriere biologiche. Il mancato funzionamento del trasportatore della creatina comporta l?assenza di creatina a livello cerebrale con la conseguenza di gravissimi danni neurologici. La creatina infatti � una molecola polare che attraversa le barriere biologiche solo per mezzo del suo trasportatore. Ad oggi non esiste nessuna terapia per tale patologia. Una possibilit� terapeutica potrebbe essere rappresentata da profarmaci della creatina in grado di attraversare le membrane cellulari e la barriera ematoencefalica (BEE) in modo indipendente dal trasportatore della creatina stessa. Questo potrebbe ripristinare il contenuto di creatina all'interno delle cellule nervose. Per raggiungere tale scopo, in questo progetto di tesi, si sono messe a punto due diverse strategie di sviluppo di derivati della creatina:
1. modificare la struttura della creatina in modo tale da ottenere una molecola maggiormente lipofila che possa attraversare le membrane biologiche per diffusione passiva.
2. realizzare derivati ottenuti dalla coniugazione della creatina con molecole che possano utilizzare un trasportatore diverso dall?SLC6A8.
I derivati sintetizzati secondo tali strategie sono stati ottenuti in buona resa e caratterizzati mediante HPLC e spettrometria di massa; alcuni di loro sono stati anche valutati dal punto di vista della stabilit� in mezzo fisiologico e degli effetti neurobiologici.
Election results can decrease intergroup threat and through that positively affect intergroup relations
Creators: name: Roth, Jenny
name: Steinmann, Miriam
name: Loughnane, Jack
name: Devine, Paula
name: Muldoon, Orla
name: Shelly, Catriona
name: van Tilburg, Wijnand A. P.
name: C. Steffens, Melanie
Publisher: name: University of Limerick
Year: 2025
Subjects: classificationCode: 52
subject: Psychology
subject: FOS: Psychology

description: Previous research has established that intergroup threat is pivotal to intergroup relations in divided societies. We used the Northern Ireland Assembly Elections in 2022 as a unique chance to investigate how elections can affect feelings of threat and intergroup relations between communities with a history of violent intergroup conflict. We argued that because of their conflicting goals, if Sinn Féin (i.e., a Republican party that promotes a united Ireland) gains more votes than the Democratic Unionist Party (DUP, i.e., a party promoting Northern Ireland's union with the United Kingdom), it would threaten DUP supporters and vice versa. We assessed whether participants supported Sinn Féin or DUP relatively to each other, intergroup threat, and intergroup bias before and after the elections (N=285). Following an election outcome where Sinn Féin gained more votes than DUP, Sinn Féin supporters showed decreased feelings of threat which in turn decreased their intergroup bias. DUP supporters, the party that received fewer votes, showed no changes in their feelings of threat or intergroup bias. This research highlights how electoral results affect intergroup relations in postconflict societies.
La vaccinazione antipneumococcica nell'adulto e nell'anziano: valutazione dell?impatto epidemiologico, dell?efficacia clinica e del profilo di tollerabilit� e sicurezza del preparato 13-valente in Liguria
Creators: name: DELUCIS, SABRINA
Publisher: name: Universit� degli studi di Genova
Year: 2018

description: The antiphneumococcic vaccination in the adult and in the elderly: evaluation of the epidemiological impact, of the clinical efficacy and tollerability and safety profile of the preparation 13-valent in Liguria