cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Co-delivery of doxorubicin and siRNA for glioma therapy by a brain targeting system: angiopep-2-modified poly(lactic-co-glycolic acid) nanoparticles
Creators: name: Wang, Lei
name: Hao, Yongwei
name: Li, Haixia
name: Li, Dong
name: Zhang, Zhenzhong
name: Zhang, Yun
name: Zhao, Yalin
name: Meng, Dehui
name: Shi, Jinjin
name: Zhang, Hongling
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Biological Sciences
subject: Chemistry
subject: Biotechnology
subject: Pharmacology
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Medicine
subject: Engineering
subject: Biochemistry
subject: Biophysics

description: It is very challenging to treat brain cancer because of the blood–brain barrier (BBB) restricting therapeutic drug or gene to access the brain. In this research project, angiopep-2 (ANG) was used as a brain-targeted peptide for preparing multifunctional ANG-modified poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs), which encapsulated both doxorubicin (DOX) and epidermal growth factor receptor (EGFR) siRNA, designated as ANG/PLGA/DOX/siRNA. This system could efficiently deliver DOX and siRNA into U87MG cells leading to significant cell inhibition, apoptosis and EGFR silencing in vitro. It demonstrated that this drug system was capable of penetrating the BBB in vivo, resulting in more drugs accumulation in the brain. The animal study using the brain orthotopic U87MG glioma xenograft model indicated that the ANG-targeted co-delivery of DOX and EGFR siRNA resulted in not only the prolongation of the life span of the glioma-bearing mice but also an obvious cell apoptosis in glioma tissue.
Synthesis of TEG-Substituted 4-(N-Methyl-N-Boc-amino)styrylpyridine as Key Precursor for Monodentate and Multidentate Imaging Agents for aβ Plaques
Creators: name: Li, Zhi
name: Liu, Bo
name: Zhu, Lin
name: Duan, Wubiao
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Chemistry
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Physiology
subject: Neuroscience
subject: Molecular Biology
subject: Cell Biology
subject: Biochemistry

description: TEG-substituted 4-(N-methyl-N-Boc-amino)styrylpyridine which can serve as key precursor for many monodentate and multidentate imaging agents for Aβ plaques in human brain has been readily synthesized with cheap starting materials. Our new method could be employed for mass production of monodentate imaging agent AV-45 and other multidentate imaging agents.
title: An update on European research on Implications of Medical Low Dose Radiation Exposure (MEDIRAD)
Creators: name: Frija, Guy
Publisher: name: ESR EuroSafe Imaging
Year: 2020
Subjects: subject: Action 9 - Facilitation of research in advanced topics of radiation protection
subject: Radiation Protection
subject: Action 13 - Stakeholder engagement and collaboration
subject: Radioprotection / Radiation dose

description: Background/introduction Description of activity and work performed Conclusion and recommendations Personal/organisational information References
description: Background/introduction: MEDIRAD – the first EURATOM project dedicated to researching the implications of medical low-dose radiation – specifically aims to enhance the scientific bases and clinical practice of radiation protection in the medical field and addresses the...
Supplementary Figure 2 from Evidence for parallel evolution of a gene involved in the regulation of spermatogenesis
Creators: name: Wang, Xin Rui
name: Ling, Li Bin
name: Hsiao Han Huang
name: Jau Jyun Lin
name: Fugmann, Sebastian D.
name: Yang, Shu Yuan
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Developmental Biology

description: The evolutionary history of PHF7/G2E3 proteins.
Supplementary Figure 5 from Evidence for parallel evolution of a gene involved in the regulation of spermatogenesis
Creators: name: Wang, Xin Rui
name: Ling, Li Bin
name: Hsiao Han Huang
name: Jau Jyun Lin
name: Fugmann, Sebastian D.
name: Yang, Shu Yuan
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Developmental Biology

description: The C-terminus of D. melanogaster PHF7 is required for the induction of female germline loss.
Laboratory Evaluation and Calibration of Three Low-Cost Particle Sensors for Particulate Matter Measurement
Creators: name: Wang, Yang
name: Li, Jiayu
name: Jing, He
name: Zhang, Qiang
name: Jiang, Jingkun
name: Biswas, Pratim
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Molecular Biology
subject: Cell Biology
subject: Engineering

description: Particle sensors offer significant advantages of compact size and low cost, and have recently drawn great attention for usage as portable monitors measuring particulate matter mass concentrations. However, most sensor systems have not been thoroughly evaluated with standardized calibration protocols, and their data quality is not well documented. In this work, three low-cost particle sensors based on light scattering (Shinyei PPD42NS, Samyoung DSM501A, and Sharp GP2Y1010AU0F) were evaluated by calibration methods adapted from the US EPA 2013 Air Sensor Workshop recommendations. With a SidePak (TSI Inc., St. Paul, MN, USA), a scanning mobility particle sizer (TSI Inc.), and an AirAssure™ PM2.5 Indoor Air Quality Monitor (TSI Inc.), which itself relies on a GP2Y1010AU0F sensor as reference instruments, six performance aspects were examined: linearity of response, precision of measurement, limit of detection, dependence on particle composition, dependence on particle size, and relative humidity and temperature influences. This work found that: (a) all three sensors demonstrated high linearity against SidePak measured concentrations, with R2 values higher than 0.8914 in the particle concentration range of 0–1000 μg/m3, and the linearity depended on the studied range of particle concentrations; (b) the standard deviations of the sensors varied from 15 to 90 μg/m3 for a concentration range of 0–1000 μg/m3; (c) the outputs of all three sensors depended highly on particle composition and size, resulting in as high as 10 times difference in the sensor outputs; and (d) humidity affected the sensor response. This article provides further recommendations for applications of the three tested sensors.Copyright 2015 American Association for Aerosol Research
title: Материалы научной конференции с международным участием "Неделя науки СПбПУ", 18–23 ноября 2019 года. Институт биомедицинских систем и биотехнологий. В 2 ч. Ч. 2, Высшая школа биомедицинских систем и технологий
Creators: name: Научная конференция с международным участием "Неделя науки СПбПУ" (2019; Санкт-Петербург)
Publisher: name: ПОЛИТЕХ-ПРЕСС
Year: 2019

description: В сборник включены статьи студентов, аспирантов, молодых ученых и сотрудников СПбПУ, университетов, научных организаций и предприятий Санкт-Петербурга, России, зарубежных стран по материалам докладов, принятых на секционные заседания конференции «Неделя науки СПбПУ» Высшей школы биомедицинских систем и технологий Института биомедицинских систем и биотехнологий. Статьи отражают современный уровень научно-исследовательской работы участников конференции в области физики материалов, нанотехнологий, медицинской физики и биоинженерии. Представляют интерес для специалистов в различных областях знаний, учащихся и работников системы высшего образования и Российской академии наук.
title: Development of CT Pelvimetry using Deep Learning base Reconstruction
Creators: name: Kitai, Takaaki
Publisher: name: ESR EuroSafe Imaging
Year: 2020
Subjects: subject: Performed at one institution
subject: Not applicable
subject: Prospective
subject: Tissue characterisation
subject: Computer Applications-3D
subject: Image manipulation / Reconstruction
subject: CT
subject: Radioprotection / Radiation dose
subject: Pelvis
subject: Foetal imaging
subject: Artificial Intelligence and Machine Learning

description: Background/introduction Description of activity and work performed Conclusion and recommendations Personal/organisational information References
description: Background/introduction: X-ray pelvimentry is typically performed for the diagnosis of the cephalopelvic disprosion (CPD) but have problem of scanning position and fetal exposure dose. Recently a new computed tomography (CT) reconstruction “deep learning based...
Electronic Supplementary Material from Does coevolution with parasites drive multiple hosts to partition their defences among species?
Creators: name: Caves, Eleanor M.
name: Stevens, Martin
name: Spottiswoode, Claire N.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 60801 Animal Behaviour

description: Tables S1 through S5
title: The Role of the ICRP Committee 3 (Medicine) in Guidance, Communication, and Collaboration Regarding Paediatric Radiation Protection
Creators: name: Applegate, Kimberly
Publisher: name: ESR EuroSafe Imaging
Year: 2020
Subjects: subject: Not applicable
subject: Not applicable
subject: Quality assurance
subject: Safety
subject: Radiation safety
subject: Dosimetry
subject: Fluoroscopy
subject: Digital radiography
subject: CT
subject: Radioprotection / Radiation dose
subject: Radiation physics
subject: Paediatric
subject: Action 7 - Radiation protection of children
subject: Not applicable

description: Background/introduction Description of activity and work performed Conclusion and recommendations Personal/organisational information References
description: Background/introduction: Background: The International Council for Radiation Protection (ICRP) is an independent, not-for-profit organization with a mission to advance for the public benefit the science of radiological protection, in particular by providing recommendations...
Synthesis of Novel Porphyrin Derivatives with Mesogenic Properties
Creators: name: Zhou, Li
name: Liu, Ping
name: Zhang, Xiaoyuan
name: Zhu, Biaobiao
name: Deng, Wenji
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Physiology
subject: Physics
subject: Engineering
subject: Biochemistry
subject: Biophysics

description: Two novel porphyrin derivatives, 5,10,15,20-tetra(4-(N-octane-carboxamide)phen-yl)porphyrin (4NC8-TPP) and 5,10,15,20-tetra(4-(N-stearyl-carboxamide)phenyl)porphyrin (4NC18-TPP), were synthesized. Their molecular structures were characterized by means of time of flight mass spectrometer (TOF-MS), nuclear magnetic resonance (NMR) and infrared spectra (IR). The thermal behaviour and morphologies of 4NC8-TPP and 4NC18-TPP were examined by thermal gravity (TG), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and polarizing optical microscope (POM). It was found that both 4NC8-TPP and 4NC18-TPP had mesogenic properties.
Supplementary Figure 1 from Evidence for parallel evolution of a gene involved in the regulation of spermatogenesis
Creators: name: Wang, Xin Rui
name: Ling, Li Bin
name: Hsiao Han Huang
name: Jau Jyun Lin
name: Fugmann, Sebastian D.
name: Yang, Shu Yuan
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Developmental Biology

description: Phylogenetic trees of PHF7 and G2E3 proteins.
title: Examination of exposure dose reduction using the digital zoom function of vascular imaging equipment and catheter visibility during digital zoom
Creators: name: Matsunari, Kazuya
Publisher: name: ESR EuroSafe Imaging
Year: 2019
Subjects: subject: Performed at one institution
subject: Experimental
subject: Retrospective
subject: Quality assurance
subject: Radiation safety
subject: Catheters
subject: Digital radiography
subject: Radioprotection / Radiation dose
subject: Interventional vascular
subject: Interventional Radiology

description: Background/introduction Description of activity and work performed Conclusion and recommendations Personal/organisational information References
description: Background/introduction: Reduction in exposure to scattered radiation is being widely investigated by interventional radiologists (1–4). For magnification of images using vascular imaging systems, the digital zoom function enables acquisition of a magnified visual field...
Comparing cone-beam CT intensity correction methods for dose recalculation in adaptive intensity-modulated photon and proton therapy for head and neck cancer
Creators: name: Belka, Claus
name: Landry, Guillaume
name: Kurz, Christopher
name: Dedes, George
name: Resch, Andreas
name: Reiner, Michael
name: Ganswindt, Ute
name: Nijhuis, Reinoud
name: Thieke, Christian
name: Parodi, Katia
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Cancer
Biological Sciences
Chemistry
Cell Biology
Medicine
Physics
Engineering
Biophysics

description: ABSTRACTBackground. Adaptive intensity-modulated photon and proton radiotherapy (IMRT and IMPT) of head and neck (H&N) cancer requires frequent three-dimensional (3D) dose calculation. We compared two approaches for dose recalculation on the basis of intensity-corrected cone-beam (CB) x-ray computed tomography (CT) images.Material and methods. For nine H&N tumor patients, virtual CTs (vCT) were generated by deformable image registration of the planning CT (pCT) to the CBCT. The second intensity correction approach used population-based lookup tables for scaling CBCT intensities to the pCT HU range (CBCTLUT). IMRT and IMPT plans were generated with a commercial treatment planning system. Dose recalculations on vCT and CBCTLUT were analyzed using a (3%, 3 mm) gamma-index analysis and comparison of normal tissue and tumor dose/volume parameters. A replanning CT (rpCT) acquired within three days of the CBCT served as reference. Single field uniform dose (SFUD) proton plans were created and recalculated on vCT and CBCTLUT for proton range comparison.Results. Dose/volume parameters showed minor differences between rpCT, vCT and CBCTLUT in IMRT, but clinically relevant deviations between CBCTLUT and rpCT in the spinal cord for IMPT. Gamma-index pass-rates were found increased for vCT with respect to CBCTLUT in IMPT (by up to 21 percentage points) and IMRT (by up to 9 percentage points) for most cases. The SFUD-based proton range assessment showed improved agreement of vCT and rpCT, with 88–99% of the depth dose profiles in beam's eye view agreeing within 3 mm. For CBCTLUT, only 80–94% of the profiles fulfilled this criterion.Conclusion. vCT and CBCTLUT are suitable options for dose recalculation in adaptive IMRT. In the scope of IMPT, the vCT approach is preferable.
title: Role of x-ray examination in late onset development dysplasia of hip, with emphasis on possible risk factors to be considered as indication for radiological examination (preliminary data)
Creators: name: Zogaj, Erjona
Publisher: name: ESR EuroSafe Imaging
Year: 2020
Subjects: subject: Performed at one institution
subject: Cross-sectional study
subject: Not applicable
subject: Education and training
subject: Dysplasias
subject: Developmental disease
subject: Technical aspects
subject: Safety
subject: Diagnostic procedure
subject: Digital radiography
subject: Conventional radiography
subject: Radioprotection / Radiation dose
subject: Paediatric
subject: Musculoskeletal joint
subject: Paediatric

description: Background/introduction Description of activity and work performed Conclusion and recommendations Personal/organisational information References
description: Background/introduction: Development dysplasia of hip (DDH) is a multifactorial pathology that includes abnormalities of hip joint. Its important to detect DHD early due to the fact that is clinically silent. Treating this pathology early and properly leads to a positive...
Electronic Supplementary Materials from Fin-fold development in paddlefish and catshark and implications for the evolution of the autopod
Creators: name: Tulenko, Frank J.
name: Massey, James L.
name: Elishka Holmquist
name: Kigundu, Gabriel
name: Thomas, Sarah
name: Smith, Susan M. E.
name: Mazan, Sylvie
name: Davis, Marcus C.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Developmental Biology
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences

description: Supplementary Tables, Figures, and Methods
MPEC 2024-U220 : 2024 US7
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 US7

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Hydrothermal synthesis and structural characterization of a three-dimensional coordination polymer on Ag(I)
Creators: name: Chen, Qi
name: Li, Yong-Hong
name: Li, Shu
name: Zhang, Xu-Dong
name: Lun, Hui-Jie
name: Li, Bei-Bei
name: Li, Ya-Min
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Chemistry
Biotechnology
Cell Biology
Physics
Biochemistry
Biophysics

description: A new coordination polymer [Ag3(1,2,4-btc)]n (1) (1,2,4-H3btc = 1,2,4-benzenetricarboxylate) has been synthesized by hydrothermal method and characterized by X-ray single crystal diffraction, elemental analysis, IR spectrum and TGA. Compound 1 exhibits a three-dimensional (3D) network consisting of the 2D layer connected by the ligand 1,2,4-btc3− which adopts a new coordination mode. Moreover, blue fluorescence at 480 nm emission was observed under 320 nm excitation.
title: Introducing PySkinDose, a novel framework for patient peak skin dose estimation in interventional radiology
Creators: name: Andersson, Jonas
Publisher: name: ESR EuroSafe Imaging
Year: 2020
Subjects: subject: Action 9 - Facilitation of research in advanced topics of radiation protection
subject: Interventional non-vascular
subject: Interventional vascular
subject: Radioprotection / Radiation dose
subject: Fluoroscopy
subject: Dosimetry
subject: Radiation effects
subject: Radiation safety
subject: Dosimetric comparison
subject: Quality assurance
subject: Retrospective
subject: Not applicable
subject: Performed at one institution

description: Background/introduction Description of activity and work performed Conclusion and recommendations Personal/organisational information References
description: Background/introduction: During interventional radiology (IR) procedures, X-ray induced skin injuries may occur due to high absorbed patient skin doses. In some complicated interventions, the skin doses to patients approach the levels of some radiotherapy treatments, which...
Appendix A and B from Mechanotransmission in endothelial cells subjected to oscillatory and multi-directional shear flow
Creators: name: Dabagh, Mahsa
name: Payman Jalali
name: Butler, Peter J.
name: Randles, Amanda
name: Tarbell, John M.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Biophysics
subject: Computational Biology
subject: 29903 Medical Physics
subject: FOS: Physical sciences

description: Local haemodynamics are linked to the non-uniform distribution of atherosclerosic lesions in arteries. Low and oscillatory (reversing in the axial flow direction) wall shear stress (WSS) induce inflammatory responses in endothelial cells (ECs) mediating disease localization. The objective of this study is to investigate computationally how the flow direction (reflected in WSS variation on the EC surface over time) influences the forces experienced by structural components of ECs that are believed to play important roles in mechanotransduction. A three-dimensional, multi-scale, multi-component, viscoelastic model of focally adhered ECs is developed, in which oscillatory WSS (reversing or non-reversing) parallel to the principal flow direction, or multi-directional oscillatory WSS with reversing axial and transverse components are applied over the EC surface. The computational model includes the glycocalyx layer, actin cortical layer, nucleus, cytoskeleton, focal adhesions (FAs), stress fibres and adherens junctions (ADJs). We show the distinct effects of atherogenic flow profiles (reversing unidirectional flow and reversing multi-directional flow) on subcellular structures relative to non-atherogenic flow (non-reversing flow). Reversing flow lowers stresses and strains due to viscoelastic effects, and multi-directional flow alters stress on the ADJs perpendicular to the axial flow direction. The simulations predict forces on integrins, ADJ filaments and other substructures in the range that activate mechanotransduction.
Supplementary materials from Plant spines deter herbivory by restricting caterpillar movement
Creators: name: Rupesh R. Kariyat
name: Hardison, Sean B.
name: Moraes, Consuelo M. De
name: Mescher, Mark C.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: fig 1 and table 1
Structural modeling of HLA-B*1502/peptide/carbamazepine/T-cell receptor complex architecture: implication for the molecular mechanism of carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis
Creators: name: Zhou, Peng
name: Zhang, Shilei
name: Wang, Yewang
name: Yang, Chao
name: Huang, Jian
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Drug-induced adverse reactions are a significant problem in healthcare worldwide and are estimated to cost billions of dollars annually in the United States. A portion of such reactions is observed to strongly associate with certain human leukocyte antigen (HLA) alleles; one of the strongest associations is the HLA-B*1502 protein with carbamazepine (CBZ)-induced Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) – the odds ratio value can even be higher than one thousand. The particularly strong association in CBZ-induced SJS/TEN suggests that the HLA-B*1502 is not only a genetic marker but also a participant in the pathogenesis of the disease. In the current study, we attempt to computationally model the atomic-level structure of the complete HLA-B*1502/peptide/CBZ/T-cell receptor (TCR) complex architecture based on prior knowledge obtained from epidemiological investigations as well as in vitro and in vivo assays. The model tells a different story about the molecular mechanism of CBZ-induced SJS/TEN from that previously reported for abacavir (ABC)-induced hypersensitivity (HSR); the CBZ molecule is located at the interface between HLA-B*1502/peptide and TCR, directly contacts the P3–P6 residues of antigen peptide, and bound within a pocket region encompassed by two TCR CDR3 fingers. Molecular dynamics simulation and binding energy analysis further reveal that the CBZ shows considerably high affinity to TCR over HLA-B*1502/peptide, which can tightly interact with the former rather than the latter. From the model, two hypotheses are proposed that can well explain most previous observations and are expected to guide next wet-lab experiments. This study could help to promote our understanding of the molecular mechanism and pathological implication underlying CBZ-induced SJS/TEN.
title: Comparison of age versus weight based Diagnostic Reference Levels (DRLs) for paediatric x-ray studies in a tertiary clinical site in the Middle East
Creators: name: Kelly, Charlotte
Publisher: name: ESR EuroSafe Imaging
Year: 2020
Subjects: subject: Performed at one institution
subject: Not applicable
subject: Retrospective
subject: Dosimetric comparison
subject: Radiation safety
subject: Audit and standards
subject: Digital radiography
subject: Radioprotection / Radiation dose
subject: Paediatric
subject: Action 7 - Radiation protection of children

description: Background/introduction Description of activity and work performed Conclusion and recommendations Personal/organisational information References
description: Background/introduction: Sidra Medicine is a new paediatric hospital in Qatar. Since the activation of the radiology service,patient doses have been recordedusing a dose monitoring system in order to establish local diagnostic reference levels. European Guidelines[1]...
SUPPL. Chondrites, Chondrules, Complimentarity and The Depletion Pattern from Cometary dust: the diversity of primitive refractory grains
Creators: name: D. H. Wooden
name: H. A. Ishii
name: M. E. Zolensky
Publisher: name: The Royal Society
Year: 2017
Subjects: Astrophysics
Solar System, Solar Physics, Planets and Exoplanets
Interstellar and Intergalactic Matter

description: Comet dust is primitive and shows significant diversity. Our knowledge of the properties of primitive cometary particles has expanded significantly through microscale investigations of cosmic dust samples (anhydrous interplanetary dust particles (IDPs), chondritic porous (CP) IDPs and UltraCarbonaceous Antarctic micrometeorites, Stardust and Rosetta), as well as through remote sensing (Spitzer IR spectroscopy). Comet dust are aggregate particles of materials unequilibrated at submicrometre scales. We discuss the properties and processes experienced by primitive matter in comets. Primitive particles exhibit a diverse range of: structure and typology; distribution of constituents; concentration and form of carbonaceous and refractory organic matter; Mg- and Fe-contents of the silicate minerals; sulfides; existence/abundance of type II chondrule fragments; high-temperature calcium–aluminium inclusions and ameboid-olivine aggregates; and rarely occurring Mg-carbonates and magnetite, whose explanation requires aqueous alteration on parent bodies. The properties of refractory materials imply there were disc processes that resulted in different comets having particular selections of primitive materials. The diversity of primitive particles has implications for the diversity of materials in the protoplanetary disc present at the time and in the region where the comets formed.
Hepatitis C virus core protein activates autophagy through EIF2AK3 and ATF6 UPR pathway-mediated MAP1LC3B and ATG12 expression
Creators: name: Wang, Ji
name: Kang, Rongyan
name: Huang, He
name: Xi, XueYan
name: Wang, Bei
name: Wang, Jianwei
name: Zhao, Zhendong
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Meta Science
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Microbiology
subject: Biochemistry

description: HCV infection induces autophagy, but how this occurs is unclear. Here, we report the induction of autophagy by the structural HCV core protein and subsequent endoplasmic reticular (ER) stress in Huh7 hepatoma cells. During ER stress, both the EIF2AK3 and ATF6 pathways of the unfolded protein response (UPR) were activated by HCV core protein. Then, these pathways upregulated transcription factors ATF4 and DDIT3. The ERN1-XBP1 pathway was not activated. Through ATF4 in the EIF2AK3 pathway, the autophagy gene ATG12 was upregulated. DDIT3 upregulated the transcription of autophagy gene MAP1LC3B (LC3B) by directly binding to the –253 to –99 base region of the LC3B promoter, contributing to the development of autophagy. Collectively, these data suggest not only a novel role for the HCV core protein in autophagy but also offer new insight into detailed molecular mechanisms with respect to HCV-induced autophagy, specifically how downstream UPR molecules regulate key autophagic gene expression.
Development of a novel method for quantification of autophagic protein degradation by AHA labeling
Creators: name: Zhang, Jianbin
name: Wang, Jigang
name: Ng, Shukie
name: Lin, Qingsong
name: Shen, Han-Ming
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Developmental Biology
subject: Biological Sciences
subject: Chemistry
subject: Biotechnology
subject: Pharmacology
subject: Physiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: Autophagy is a catabolic process during which cellular components including protein aggregates and organelles are degraded via a lysosome-dependent process to sustain metabolic homeostasis during nutrient or energy deprivation. Measuring the rate of proteolysis of long-lived proteins is a classical assay for measurement of autophagic flux. However, traditional methods, such as a radioisotope labeling assay, are technically tedious and have low sensitivity. Here, we report a novel method for quantification of long-lived protein degradation based on L-azidohomoalanine (AHA) labeling in mouse embryonic fibroblasts (MEFs) and in human cancer cells. AHA is a surrogate for L-methionine, containing a bio-orthogonalazide moiety. When added to cultured cells, AHA is incorporated into proteins during active protein synthesis. After a click reaction between an azide and an alkyne, the azide-containing proteins can be detected with an alkyne-tagged fluorescent dye, coupled with flow cytometry. Induction of autophagy by starvation or mechanistic target of rapamycin (MTOR) inhibitors was able to induce a significant reduction of the fluorescence intensity, consistent with other autophagic markers. Coincidently, inhibition of autophagy by pharmacological agents or by Atg gene deletion abolished the reduction of the fluorescence intensity. Compared with the classical radioisotope pulse-labeling method, we think that our method is sensitive, quantitative, nonradioactive, and easy to perform, and can be applied to both human and animal cell culture systems.
Supplementary Materials from Optimizing mating encounters by sexually dimorphic movements
Creators: name: Mizumoto, Nobuaki
name: Abe, Masato S.
name: Dobata, Shigeto
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Biophysics
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 10202 Biological Mathematics
subject: FOS: Mathematics

description: Figs S1-S7 and Table S1
The natural compound oblongifolin C inhibits autophagic flux and enhances antitumor efficacy of nutrient deprivation
Creators: name: Wan, Gang
name: Wang, Xiaoyu
name: Xu, Wei
name: Xu, Danqing
name: Xie, Weidong
name: Zhang, Yaou
name: Xu, Hongxi
name: Xu, Naihan
name: Lao, Yuanzhi
name: Liu, Zhenyan
name: Ruan, Ping
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Hematology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Marine Biology
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Physiology
subject: Molecular Biology
subject: Cell Biology
subject: Biochemistry

description: Metabolic stress induces autophagy as an alternative source of energy and metabolites. Insufficient autophagy in nutrient-deprived cancer cells would be beneficial for cancer therapy. Here, we performed a functional screen in search of novel autophagy regulators from natural products. We showed that oblongifolin C (OC), a natural small molecule compound extracted from Garcinia yunnanensis Hu, is a potent autophagic flux inhibitor. Exposure to OC results in an increased number of autophagosomes and impaired degradation of SQSTM1/p62. Costaining of GFP-LC3B with LysoTracker Red or LAMP1 antibody demonstrates that autophagosome-lysosome fusion is blocked by OC treatment. Furthermore, OC inhibits lysosomal proteolytic activity by altering lysosomal acidification and downregulating the expression of lysosomal cathepsins. Importantly, OC can eliminate the tolerance of cancer cells to nutrient starvation. Starvation dramatically increases the susceptibility of cancer cells to OC-induced CASP3-dependent apoptosis in vitro. Subsequent studies in xenograft mouse model showed that OC has anticancer potency as revealed by increased staining of cleaved CASP3, LC3 puncta, and SQSTM1, as well as reduced expression of lysosomal cathepsins. Combined treatment with OC and caloric restriction potentiates anticancer efficacy of OC in vivo. Collectively, these data demonstrated that OC is a novel autophagic flux inhibitor and might be useful in anticancer therapy.
title: Occupational radiation doses to the staff of the interventional departments of the medical institution
Creators: name: Bondarevskyi-Kolotii, Viacheslav
Publisher: name: ESR EuroSafe Imaging
Year: 2019
Subjects: subject: Retrospective
subject: Dosimetric comparison
subject: Diagnostic procedure
subject: Fluoroscopy
subject: Radioprotection / Radiation dose
subject: Action 5 - Performance indicators for radiation protection management
subject: Observational
subject: Performed at one institution

description: Background/introduction Description of activity and work performed Conclusion and recommendations Personal/organisational information References
description: Background/introduction: Medical personnel involved in interventions in interventional radiology are exposed to occupational exposure and are therefore at risk of radiation-induced diseases. Therefore, individual dosimetric control is an essential component of ensuring safe...
title: Dosimetry for imaging in clinical practice
Creators: name: Vano, Eliseo
Publisher: name: ESR EuroSafe Imaging
Year: 2020
Subjects: subject: Not applicable
subject: Not applicable
subject: Education and training
subject: Dosimetric comparison
subject: Technical aspects
subject: Radiation safety
subject: Fluoroscopy
subject: CT
subject: Conventional radiography
subject: Radioprotection / Radiation dose
subject: Radiation physics
subject: Action 5 - Performance indicators for radiation protection management

description: Background/introduction Description of activity and work performed Conclusion and recommendations Personal/organisational information References
description: Background/introduction: The Eurosafe Imaging campaign is an initiative under the ESR (European Society of Radiology). In 2019, Eurosafe launched a new Working Group (WG) on “Dosimetry for imaging in clinical practice” with the aim to suggest realistic approaches to...
title: Материалы научной конференции с международным участием "Неделя науки СПбПУ", 18–23 ноября 2019 года. Институт передовых производственных технологий
Creators: name: Научная конференция с международным участием "Неделя науки СПбПУ" (2019; Санкт-Петербург)
Publisher: name: ПОЛИТЕХ-ПРЕСС
Year: 2019

description: В сборник включены статьи студентов, аспирантов, молодых ученых и сотрудников СПбПУ, университетов, научных организаций и предприятий Санкт-Петербурга, России, зарубежных стран по материалам докладов, принятых на секционные заседания конференции «Неделя науки СПбПУ» Института передовых производственных технологий. Статьи отражают современный уровень научно-исследовательской работы участников конференции в области компьютерного инжиниринга, цифрового производства, предпринимательства и технологического лидерства. Представляют интерес для специалистов в различных областях знаний, учащихся и работников системы высшего образования и Российской академии наук
Utilizing 19F NMR to investigate drug disposition early in drug discovery
Creators: name: Hu, Haitao
name: Yi, Ping
name: Huang, Naijia
name: Hui, Yu-Hua
name: D. Dally, Robert
name: J. Ehlhardt, William
name: Kulanthaivel, Palaniappan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Infectious Diseases
subject: FOS: Health sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Biotechnology
subject: Pharmacology
subject: Physiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Medicine
subject: Biochemistry
subject: Biophysics

description: 1. Nuclear magnetic resonance (NMR), a non-selective and inherently quantitative method, has not been widely used as a quantitative tool for characterizing the disposition of lead molecules prior to clinical development. As a test case, we have chosen a fluoropyrimidine compound in lead optimization phase and evaluated its disposition following oral administration to rats using 19F NMR.2. Urine, bile and feces from individual rats were profiled and the amount of dose eliminated in each matrix was calculated. The results indicated that, in male rats, the mean dose eliminated over 0–48 h was 40%, with 28% in urine, 9% in bile and 3% in feces. In female rats, the mean dose recovered in excreta over the same period was 55%, with 40% in urine, 8% in bile and 7% in feces.3. In addition, plasma from rats and plasma from toxicology study in dogs were also profiled and exposure of circulating entities was determined. Plasma exposure determined by 19F NMR was in good agreement with those determined by conventional LC-MS/MS method, suggesting quantitative 19F NMR can be reliably used to estimate single dose or steady-state systemic exposure of circulating entities in animals and humans.
Six SQSTM1 mutations in a Chinese amyotrophic lateral sclerosis cohort
Creators: name: Yang, Yi
name: Tang, Lu
name: Zhang, Nan
name: Pan, Lei
name: Hadano, Shinji
name: Fan, Dongsheng
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Virology
subject: Developmental Biology
subject: Biological Sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Microbiology
subject: Medicine

description: The purpose of this study was to identify SQSTM1 gene mutations, estimate survival based on the progression rate of the revised amyotrophic lateral sclerosis functional rating scale (ALSFRS-R) score (ΔFS), and characterize the relationships between SQSTM1 mutations and clinical phenotypes in Chinese ALS patients. We sequenced the SQSTM1 gene in 35 familial ALS patients, 436 sporadic ALS patients, and 384 healthy controls. SQSTM1 gene mutations were screened with PCR and direct sequencing; the correlations between genotype and phenotype and the progressive ALSFRS-R ratio were analyzed. Results revealed six heterozygous missense mutations in 471 ALS patients: c.241 G> A (p.E81K), c.717 C> A (p.N239K), c.889 G> A (p.G297S), c.1116 G> C (p.E372D), c.1162 C> T (p.P388S) and c.1175 C> T (p.P392 L). The gender ratio was 1:1, and the limb was the site of disease onset in mutation-positive patients. Notably, the ΔFS analysis revealed that the risk of death or tracheostomy was significantly increased in SQSTM1 mutation carriers (p < 0.05). In conclusion, E81K, N239K, G297S, E372D, P388S and P392 L were detected in the PB1, TRAF6, PEST and UBA domains, which are important to p62 function and prone to ALS. The incidence of ALS caused by the SQSTM1 mutation has increased from 30 to 35 worldwide.
title: Pediatric hospital experience for the diminishing of radiation overexposure
Creators: name: Hambardzumyan, Andrias
Publisher: name: ESR EuroSafe Imaging
Year: 2019
Subjects: subject: Action 7 - Radiation protection of children
subject: Management
subject: Paediatric
subject: Radioprotection / Radiation dose
subject: CT
subject: MR
subject: Ultrasound
subject: Equipment
subject: Radiation safety
subject: Acute
subject: Retrospective
subject: Not applicable
subject: Performed at one institution

description: Background/introduction Description of activity and work performed Conclusion and recommendations Personal/organisational information References
description: Background/introduction: The number of medicalX-rayimagingprocedures is growing exponentially across the globe. Even though the overall benefit from medicalX-rayimagingprocedures far outweighs any associated risks, it is crucial to take all necessary steps to minimize...
title: Practical experience from a multicentre project on paediatric x-ray imaging optimization: Data collection challenges
Creators: name: Delis, Harry
Publisher: name: ESR EuroSafe Imaging
Year: 2020
Subjects: subject: Multicentre study
subject: Experimental
subject: Not applicable
subject: Quality assurance
subject: Radiation safety
subject: Physics
subject: Dosimetry
subject: Fluoroscopy
subject: CT
subject: Conventional radiography
subject: Radioprotection / Radiation dose
subject: Radiation physics
subject: Paediatric
subject: Action 7 - Radiation protection of children

description: Background/introduction Description of activity and work performed Conclusion and recommendations Personal/organisational information References
description: Background/introduction: Optimization is a fundamental process in medical imaging asa tool of continuous quality improvementand as requirement by international safety guidelines [1]. Evaluation of practices that will eventually lead to their optimization can be motivated...
Blog | New Feature Alert! Verifying your Email
Creators: name: Demain, Paula
Publisher: name: ORCID
Year: 2017
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences

description: Blog post published April 24, 2017Continuing our series of posts on updates to the ORCID Registry user interface, in this post we describe the relationship between verifying your email and managing your ORCID record manually.
Bibliography for newcomers to translation & interpreting studies
Creators: name: Apfelthaler, Matthias
name: Hebenstreit, Gernot
Publisher: name: figshare
Year: 2017
Subjects: subject: 200323 Translation and Interpretation Studies
subject: FOS: Languages and literature

description: This is a bibliography for newcomers to translation and interpreting studies, and covers general introductions and reference works. We will update this bibliography at least once a year.
title: Utilisation of a radiation dose monitoring system for optimisation of patient dose in a paediatric hospital
Creators: name: Kelly, Charlotte
Publisher: name: ESR EuroSafe Imaging
Year: 2020
Subjects: subject: Performed at one institution
subject: Not applicable
subject: Retrospective
subject: Quality assurance
subject: Radiation safety
subject: Fluoroscopy
subject: Digital radiography
subject: CT
subject: Radioprotection / Radiation dose
subject: Paediatric
subject: Action 4 - Dose management systems

description: Background/introduction Description of activity and work performed Conclusion and recommendations Personal/organisational information References
description: Background/introduction: Sidra Medicine is a recently activated paediatric hospital in Qatar. The radiology department initiated the use of a dose monitoring system alongside service activation, which had the distinct advantage of embedding the dose monitoting system in...
ORCID Board Meeting Summary 20170228
Creators: name: Haak Laurel
name: Kiermer, Veronique
name: Ewenstein, Jackie
Publisher: name: ORCID
Year: 2017
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences

description: ORCID Board meeting summary for meeting date 28th February - 1st March 2017
The serum lipid profiles of amyotrophic lateral sclerosis patients: A study from south-west China and a meta-analysis
Creators: name: Huang, Rui
name: Guo, Xiaoyan
name: Chen, Xueping
name: Zheng, Zhenzhen
name: Wei, Qianqian
name: Cao, Bei
name: Zeng, Yan
name: Shang, Huifang
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: Science Policy
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cell Biology
subject: Medicine

description: Associations between the fasting levels of serum lipid and amyotrophic lateral sclerosis (ALS) in Chinese populations remain largely unknown. Our objective was to analyse data from a cohort of ALS patients to determine these associations. Four hundred and thirteen ALS patients and 400 age- and gender-matched healthy controls were included. Fasting serum lipid concentration of all subjects, including total cholesterol, low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C) and triglyceride (TG), were measured at the time of first visit. The revised ALS Functional Rating Scale (ALSFRS-R) was used to assess the severity of ALS. Systems Analysis by Review Manager 5 was used to evaluate differences in dyslipidaemia between ALS patients and controls. Results showed that ALS patients with higher triglyceride levels had longer survival time compared to patients with lower triglyceride levels (p < 0.05). We found a median prolonged life expectancy of 5.8 months for patients with serum triglyceride levels above the median of 127.5 mg/dl. Cox regression analysis indicated that disease duration and age were positively correlated with death, and triglyceride was positively correlated with survival. A meta-analysis indicated that there were no significant differences in mean total cholesterol, TG, LDL or the LDL/HDL ratio between patients and controls. In conclusion, high serum TG might be a protective factor for the survival of patients with ALS.
Interaction of organic carbon, reduced sulphur and nitrate in anaerobic baffled reactor for fresh leachate treatment
Creators: name: Yin, Zhixuan
name: Xie, Li
name: Khanal, Samir Kumar
name: Zhou, Qi
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Interaction of organic carbon, reduced sulphur and nitrate was examined using anaerobic baffled reactor for fresh leachate treatment by supplementing nitrate and/or sulphide to compartment 3. Nitrate was removed completely throughout the study mostly via denitrification (>80%) without nitrite accumulation. Besides carbon source, various reduced sulphur (e.g. sulphide, elemental sulphur and organic sulphur) could be involved in the nitrate reduction process via sulphur-based autotrophic denitrification when dissolved organic carbon/nitrate ratio decreased below 1.6. High sulphide concentration not only stimulated autotrophic denitrification, but it also inhibited heterotrophic denitrification, resulting in a shift (11–20%) from heterotrophic denitrification to dissimilatory nitrate reduction to ammonia. High-throughput 16S rRNA gene sequencing analysis further confirmed that sulphur-oxidizing nitrate-reducing bacteria were stimulated with increase in the proportion of bacterial population from 18.6% to 27.2% by high sulphide concentration, meanwhile, heterotrophic nitrate-reducing bacteria and fermentative bacteria were inhibited with 25.5% and 66.6% decrease in the bacterial population.
Australian Literary Studies, 20(3) 2002. University of Queensland Press. ISSN 0004-9697 [Book review]
Creators: name: James, Caron
Publisher: name: Monash University
Year: 2017
Subjects: subject: 200502 Australian Literature (excl. Aboriginal and Torres Strait Islander Literature)
subject: FOS: Languages and literature

description: This issue of Australian Literary Studies presents articles on what at first would seem a disparate selection of subjects and topics. On closer examination, however, most of the articles could be linked to a discussion of the experience of the "Other", one of the more fashionable of current critical concepts.