Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
Creators: name: Galluzzi, Lorenzo
name: Vitale, Ilio
name: Aaronson, Stuart A
name: Abrams, John M
name: Adam, Dieter
name: Agostinis, Patrizia
name: Alnemri, Emad S
name: Altucci, Lucia
name: Amelio, Ivano
name: Andrews, David W
name: Annicchiarico-Petruzzelli, Margherita
name: Antonov, Alexey V
name: Arama, Eli
name: Baehrecke, Eric H
name: Barlev, Nickolai A
name: Bazan, Nicolas G
name: Bernassola, Francesca
name: Bertrand, Mathieu JM
name: Bianchi, Katiuscia
name: Blagosklonny, Mikhail V
name: Blomgren, Klas
name: Borner, Christoph
name: Boya, Patricia
name: Brenner, Catherine
name: Campanella, Michelangelo
name: Candi, Eleonora
name: Carmona-Gutierrez, Didac
name: Cecconi, Francesco
name: Chan, Francis KM
name: Chandel, Navdeep S
name: Cheng, Emily H
name: Chipuk, Jerry E
name: Cidlowski, John A
name: Ciechanover, Aaron
name: Cohen, Gerald M
name: Conrad, Marcus
name: Cubillos-Ruiz, Juan R
name: Czabotar, Peter E
name: D'Angiolella, Vincenzo
name: Dawson, Ted M
name: Dawson, Valina L
name: De Laurenzi, Vincenzo
name: De Maria, Ruggero
name: Debatin, Klaus-Michael
name: DeBerardinis, Ralph J
name: Deshmukh, Mohanish
name: Di Daniele, Nicola
name: Di Virgilio, Francesco
name: Dixit, Vishva M
name: Dixon, Scott J
name: Duckett, Colin S
name: Dynlacht, Brian D
name: El-Deiry, Wafik S
name: Elrod, John W
name: Fimia, Gian Maria
name: Fulda, Simone
name: García-Sáez, Ana J
name: Garg, Abhishek D
name: Garrido, Carmen
name: Gavathiotis, Evripidis
name: Golstein, Pierre
name: Gottlieb, Eyal
name: Green, Douglas R
name: Greene, Lloyd A
name: Gronemeyer, Hinrich
name: Gross, Atan
name: Hajnoczky, Gyorgy
name: Hardwick, J Marie
name: Harris, Isaac S
name: Hengartner, Michael O
name: Hetz, Claudio
name: Ichijo, Hidenori
name: Jäättelä, Marja
name: Joseph, Bertrand
name: Jost, Philipp J
name: Juin, Philippe P
name: Kaiser, William J
name: Karin, Michael
name: Kaufmann, Thomas
name: Kepp, Oliver
name: Kimchi, Adi
name: Kitsis, Richard N
name: Klionsky, Daniel J
name: Knight, Richard A
name: Kumar, Sharad
name: Lee, Sam W
name: Lemasters, John J
name: Levine, Beth
name: Linkermann, Andreas
name: Lipton, Stuart A
name: Lockshin, Richard A
name: López-Otín, Carlos
name: Lowe, Scott W
name: Luedde, Tom
name: Lugli, Enrico
name: MacFarlane, Marion
name: Madeo, Frank
name: Malewicz, Michal
name: Malorni, Walter
name: Manic, Gwenola
name: Marine, Jean-Christophe
name: Martin, Seamus J
name: Martinou, Jean-Claude
name: Medema, Jan Paul
name: Mehlen, Patrick
name: Meier, Pascal
name: Melino, Sonia
name: Miao, Edward A
name: Molkentin, Jeffery D
name: Moll, Ute M
name: Muñoz-Pinedo, Cristina
name: Nagata, Shigekazu
name: Nuñez, Gabriel
name: Oberst, Andrew
name: Oren, Moshe
name: Overholtzer, Michael
name: Pagano, Michele
name: Panaretakis, Theocharis
name: Pasparakis, Manolis
name: Penninger, Josef M
name: Pereira, David M
name: Pervaiz, Shazib
name: Peter, Marcus E
name: Piacentini, Mauro
name: Pinton, Paolo
name: Prehn, Jochen HM
name: Puthalakath, Hamsa
name: Rabinovich, Gabriel A
name: Rehm, Markus
name: Rizzuto, Rosario
name: Rodrigues, Cecilia MP
name: Rubinsztein, David C
name: Rudel, Thomas
name: Ryan, Kevin M
name: Sayan, Emre
name: Scorrano, Luca
name: Shao, Feng
name: Shi, Yufang
name: Silke, John
name: Simon, Hans-Uwe
name: Sistigu, Antonella
name: Stockwell, Brent R
name: Strasser, Andreas
name: Szabadkai, Gyorgy
name: Tait, Stephen WG
name: Tang, Daolin
name: Tavernarakis, Nektarios
name: Thorburn, Andrew
name: Tsujimoto, Yoshihide
name: Turk, Boris
name: Berghe, Tom Vanden
name: Vandenabeele, Peter
name: Heiden, Matthew G Vander
name: Villunger, Andreas
name: Virgin, Herbert W
name: Vousden, Karen H
name: Vucic, Domagoj
name: Wagner, Erwin F
name: Walczak, Henning
name: Wallach, David
name: Wang, Ying
name: Wells, James A
name: Wood, Will
name: Yuan, Junying
name: Zakeri, Zahra
name: Zhivotovsky, Boris
name: Zitvogel, Laurence
name: Melino, Gerry
name: Kroemer, Guido
Publisher: name: The Francis Crick Institute
Year: 2021
Subjects: classificationCode: Metabolism
subject: Metabolism
classificationCode: Cell Biology
subject: Cell Biology
classificationCode: Signalling & Oncogenes
subject: Signalling &amp; Oncogenes

description: Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.