title: ÐÐ»Ð¸ÑÐ½Ð¸Ðµ ÑÐºÑÑÑÐ°ÐºÑÐ° ÐºÐ°ÑÐ¾ÑÐ¸Ð½Ð¾Ð¸Ð´Ð¾Ð² Ð¸Ð· Ð±Ð¸Ð¾Ð¼Ð°ÑÑÑ Ð²Ð¾Ð´Ð¾ÑÐ¾ÑÐ»ÐµÐ¹ Chlorella vulgaris Ð½Ð° Ð³ÐµÐ¼Ð¾Ð¿Ð¾ÑÐ· Ñ Ð¼ÑÑÐµÐ¹ Ñ ÐºÐ°ÑÑÐ¸Ð½Ð¾Ð¼Ð¾Ð¹ Ð­ÑÐ»Ð¸Ñ Ð° Ð¿ÑÐ¸ Ð»ÐµÑÐµÐ½Ð¸Ð¸ ÑÐ¸ÑÐ¿Ð»Ð°ÑÐ¸Ð½Ð¾Ð¼
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Influence of carotenoid extract from the biomass of Chlorella vulgaris algae on hematopoiesis in mice with Ehrlich's carcinoma treated with cisplatin
Creators: name: ÐÐ°ÑÐºÐ°ÑÐ¾Ð²Ð°, ÐÐ»Ð¸Ð·Ð°Ð²ÐµÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: Ð¾Ð¿ÑÑ Ð¾Ð»Ñ Ð­ÑÐ»Ð¸ÐºÐ°
ÐºÐ°ÑÐ¾ÑÐ¸Ð½Ð¾Ð¸Ð´Ñ
ÑÐ¸ÑÐ¿Ð»Ð°ÑÐ¸Ð½
Erlich tumors
carotenoids
cisplatin

description: ÐÐ° 55 Ñ., 14 ÑÐ¸ÑÑÐ½ÐºÐ¾Ð², 4 ÑÐ°Ð±Ð»Ð¸ÑÑ. Ð¦ÐµÐ»Ñ Ð²ÑÐ¿ÑÑÐºÐ½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ Ð·Ð°ÐºÐ»ÑÑÐ°ÐµÑÑÑ Ð² Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¸ Ð²Ð»Ð¸ÑÐ½Ð¸Ñ ÑÐºÑÑÑÐ°ÐºÑÐ° ÐºÐ°ÑÐ¾ÑÐ¸Ð½Ð¾Ð¸Ð´Ð¾Ð² Ð¸Ð· Ð±Ð¸Ð¾Ð¼Ð°ÑÑÑ Ð²Ð¾Ð´Ð¾ÑÐ¾ÑÐ»Ð¸ ChlorellavulgarisÐ½Ð° ÐºÐ¾Ð»Ð¸ÑÐµÑÑÐ²Ð¾ ÑÐ¾ÑÐ¼ÐµÐ½Ð½ÑÑ ÑÐ»ÐµÐ¼ÐµÐ½ÑÐ¾Ð² ÐºÑÐ¾Ð²Ð¸ Ð¸ ÐºÐ¾Ð½ÑÐµÐ½ÑÑÐ°ÑÐ¸Ð¸ Ð³ÐµÐ¼Ð¾Ð³Ð»Ð¾Ð±Ð¸Ð½Ð° Ñ Ð¼ÑÑÐµÐ¹ Ð»Ð¸Ð½Ð¸Ð¸ BALB/c Ñ ÐºÐ°ÑÑÐ¸Ð½Ð¾Ð¼Ð¾Ð¹ Ð­ÑÐ»Ð¸ÑÐ° Ð¿ÑÐ¸ Ð»ÐµÑÐµÐ½Ð¸Ð¸ ÑÐ¸Ð¼Ð¸Ð¾ÑÐµÑÐ°Ð¿ÐµÐ²ÑÐ¸ÑÐµÑÐºÐ¸Ð¼ Ð»ÐµÐºÐ°ÑÑÑÐ²Ð¾Ð¼ Ð¦Ð¸ÑÐ¿Ð»Ð°ÑÐ¸Ð½-ÐÐ­ÐÐ¡.ÐÐ»Ñ ÑÐµÑÐµÐ½Ð¸Ñ Ð¿Ð¾ÑÑÐ°Ð²Ð»ÐµÐ½Ð½Ð¾Ð¹ ÑÐµÐ»Ð¸ ÑÐµÑÐ°Ð»Ð¸ÑÑ Ð½Ð¸Ð¶ÐµÐ¿ÐµÑÐµÑÐ¸ÑÐ»ÐµÐ½Ð½ÑÐµ Ð·Ð°Ð´Ð°ÑÐ¸:- ÐÐµÑÐµÐ²Ð¸ÑÑ ÑÑÐ°Ð¼Ð¼ Ð¾Ð¿ÑÑÐ¾Ð»Ð¸ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÐ¼ Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÐ¼;- Ð Ð°Ð½Ð´Ð¾Ð¼Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°ÑÑ Ð½Ð° Ð³ÑÑÐ¿Ð¿Ñ Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÑ Ñ Ð¿ÐµÑÐµÐ²Ð¸ÑÑÐ¼ ÑÑÐ°Ð¼Ð¼Ð¾Ð¼ Ð¾Ð¿ÑÑÐ¾Ð»Ð¸ Ð­ÑÐ»Ð¸ÑÐ°;- ÐÐ·ÑÑÑ ÐºÑÐ¾Ð²Ñ Ñ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÑ Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÑ Ð´Ð»Ñ Ð´Ð°Ð»ÑÐ½ÐµÐ¹ÑÐµÐ³Ð¾ Ð°Ð½Ð°Ð»Ð¸Ð·Ð°;-Â ÐÑÐ¾Ð²ÐµÑÑÐ¸ Ð°Ð½Ð°Ð»Ð¸Ð· ÐºÑÐ¾Ð²Ð¸ Ð½Ð° ÐºÐ¾Ð»Ð¸ÑÐµÑÑÐ²Ð¾ ÑÐ¾ÑÐ¼ÐµÐ½Ð½ÑÑ ÑÐ»ÐµÐ¼ÐµÐ½ÑÐ¾Ð² Ð¸ ÐºÐ¾Ð½ÑÐµÐ½ÑÑÐ°ÑÐ¸Ñ Ð³ÐµÐ¼Ð¾Ð³Ð»Ð¾Ð±Ð¸Ð½Ð°;- ÐÑÐ¾Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°ÑÑ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÐµ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¸ ÑÐ´ÐµÐ»Ð°ÑÑ Ð²ÑÐ²Ð¾Ð´ Ð¿Ð¾ Ð²ÑÐµÐ¹ ÑÐ°Ð±Ð¾ÑÐµ.ÐÐ±ÑÐµÐºÑÐ°Ð¼Ð¸ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð±ÑÐ»Ð¸ Ð³ÑÑÐ¿Ð¿Ñ Ð¼ÑÑÐµÐ¹ Ñ Ð¿ÐµÑÐµÐ²Ð¸ÑÐ¾Ð¹ Ð¾Ð¿ÑÑÐ¾Ð»ÑÑ Ð­ÑÐ»Ð¸ÑÐ°.Ð­ÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½Ð¾-Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°ÑÐµÐ»ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸Ð»Ð°ÑÑ Ð² Ð½Ð°ÑÑÐ½Ð¾Ð¹ Ð»Ð°Ð±Ð¾ÑÐ°ÑÐ¾ÑÐ¸Ð¸ ÑÐ¸Ð¼Ð¸Ð¾Ð¿ÑÐ¾ÑÐ¸Ð»Ð°ÐºÑÐ¸ÐºÐ¸ ÑÐ°ÐºÐ° Ð¸ Ð¾Ð½ÐºÐ¾ÑÐ°ÑÐ¼Ð°ÐºÐ¾Ð»Ð¾Ð³Ð¸Ð¸ Ð¤ÐÐÐ£ Â«ÐÐÐÐ¦ Ð¾Ð½ÐºÐ¾Ð»Ð¾Ð³Ð¸Ð¸ Ð¸Ð¼. Ð. Ð. ÐÐµÑÑÐ¾Ð²Ð°Â» ÐÐ¸Ð½Ð·Ð´ÑÐ°Ð²Ð° Ð Ð¤. ÐÐ½Ð°Ð»Ð¸Ð·Ð¸ÑÑÐµÐ¼ÑÐ¼Ð¸ Ð¿Ð¾ÐºÐ°Ð·Ð°ÑÐµÐ»ÑÐ¼Ð¸ Ð±ÑÐ»Ð¾ ÐºÐ¾Ð»Ð¸ÑÐµÑÑÐ²Ð¾ Ð»ÐµÐ¹ÐºÐ¾ÑÐ¸ÑÐ¾Ð², ÑÑÐ¸ÑÑÐ¾ÑÐ¸ÑÐ¾Ð², ÑÑÐ¾Ð¼Ð±Ð¾ÑÐ¸ÑÐ¾Ð² Ð² ÐºÑÐ¾Ð²Ð¸, ÐºÐ¾Ð½ÑÐµÐ½ÑÑÐ°ÑÐ¸Ñ Ð³ÐµÐ¼Ð¾Ð³Ð»Ð¾Ð±Ð¸Ð½Ð°.Ð ÑÐ¾Ð´Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¹ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð½Ð¾, ÑÑÐ¾ Ð¿ÑÐ¸ Ð»ÐµÑÐµÐ½Ð¸Ð¸ ÑÐ¸Ð¼Ð¸Ð¾Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ¾Ð¼ Ð¦Ð¸ÑÐ¿Ð»Ð°ÑÐ¸Ð½-ÐÐ­ÐÐ¡ Ð² ÑÐ¾ÑÐµÑÐ°Ð½Ð¸Ð¸ Ñ ÑÐºÑÑÑÐ°ÐºÑÐ¾Ð¼ ÐºÐ°ÑÐ¾ÑÐ¸Ð½Ð¾Ð¸Ð´Ð¾Ð² Ð¸Ð· Ð±Ð¸Ð¾Ð¼Ð°ÑÑÑ Ð²Ð¾Ð´Ð¾ÑÐ¾ÑÐ»Ð¸ Chlorellavulgaris ÐºÐ¾Ð»Ð¸ÑÐµÑÑÐ²Ð¾ Ð»ÐµÐ¹ÐºÐ¾ÑÐ¸ÑÐ¾Ð² ÑÐ½Ð¸Ð·Ð¸Ð»Ð¾ÑÑ Ð² ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ð¸ Ñ ÐºÐ¾Ð½ÑÑÐ¾Ð»ÐµÐ¼, ÐºÐ¾Ð»Ð¸ÑÐµÑÑÐ²Ð¾ ÑÑÐ¸ÑÑÐ¾ÑÐ¸ÑÐ¾Ð² Ð¸ ÐºÐ¾Ð½ÑÐµÐ½ÑÑÐ°ÑÐ¸Ñ Ð³ÐµÐ¼Ð¾Ð³Ð»Ð¾Ð±Ð¸Ð½Ð° Ð¾ÑÑÐ°Ð»Ð°ÑÑ Ð½ÐµÐ¸Ð·Ð¼ÐµÐ½Ð½Ð¾Ð¹ Ð² ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ð¸ Ñ Ð¾ÑÐ´ÐµÐ»ÑÐ½ÑÐ¼ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸ÐµÐ¼ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ° Ð¦Ð¸ÑÐ¿Ð»Ð°ÑÐ¸Ð½-ÐÐ­ÐÐ¡, ÐºÐ¾Ð»Ð¸ÑÐµÑÑÐ²Ð¾ ÑÑÐ¾Ð¼Ð±Ð¾ÑÐ¸ÑÐ¾Ð² Ð¾ÑÑÐ°Ð»Ð¾ÑÑ Ð½ÐµÐ¸Ð·Ð¼ÐµÐ½Ð½ÑÐ¼.
description: 55 pages, 14 figures, 4 tables. The purpose of this research is to study the effect of carotenoid extract from the biomass of the alga Chlorella vulgaris on the number of blood cells and hemoglobin concentration in BALB/c mice with Ehrlich's carcinoma during treatment with the chemotherapy drug Cisplatin-LENS.To achieve this goal, the following tasks were solved:- Transplant the tumor strain into experimental animals;- Randomize to groups of animals inoculated with Ehrlich's tumor strain;- Take blood from experimental animals for further analysis;- Carry out a blood test for the number of formed elements and the concentration of hemoglobin;- Analyze the results obtained and draw a conclusion on the entire work.The objects of the study were groups of mice with transplanted Ehrlich's tumor.Experimental research work was carried out in the scientific laboratory of cancer chemoprophylaxis and oncopharmacology of the Federal State Budgetary Institution âN. N. Petrovâ of the Ministry of Health of the Russian Federation. The analyzed parameters were the number of leukocytes, erythrocytes, platelets in the blood, hemoglobin concentration.Studies have shown that during treatment with the chemotherapy drug Cisplatin-LENS in combination with an extract of carotenoids from the biomass of the alga Chlorella vulgaris, the number of leukocytes decreased in comparison with the control, the number of erythrocytes and the concentration of hemoglobin remained unchanged in comparison with the separate use of the drug Cisplatin - LANCE, the platelet count remained unchanged.