cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Gas–liquid equilibrium data for mixture gas of carbon dioxide + nitrogen in 1,2-ethanediamine + triethylene glycol aqueous solution
Creators: name: Li, Qiang
name: Zhao, Tianxiang
name: Chang, Yan
name: Zhang, Jianbin
name: Zhang, Qiancheng
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology

description: Isothermal gas–liquid equilibrium (GLE) data were measured for the system of 1,2-ethanediamine (EDA) + triethylene glycol (TEG) + H2O + carbon dioxide (CO2) + N2 at T = 293.15, 298.15, 303.15 and 308.15 K and p = 121.74, 126.94 and 129.87 kPa with CO2 partial pressure ranging from 0 to 13.0 kPa. Measurements were carried out using a saturation method in a glass absorption apparatus, which was controlled at the constant temperature by a thermostatic circulation bath with a Beckmann thermometer. The measurement uncertainties for temperature, total pressure, CO2 concentration in the gas phase and CO2 concentration in the liquid phase were less than ±0.02 K, ±0.15 kPa, ±2.5% and ±0.6, respectively. The results indicate that the addition of TEG into the aqueous EDA solution could significantly improve the stability of EDA in CO2 absorption process, thus enhancing the performance of aqueous amine-based CO2 scrubbing.
title: 02_0083
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: Laboratoire de Médiévistique Occidentale de Paris
subject: LaMOP

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Pharmacokinetic comparisons of Paeoniflorin and Paeoniflorin-6'O-benzene sulfonate in rats via different routes of administration
Creators: name: Wang, Chun
name: Yuan, Jun
name: Ling Zhang, Ling
name: Wei, Wei
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: 1. The pharmacokinetics study of Paeoniflorin (Pae) and its acylated derivative (CP-25) was performed. 2. The structure of CP-25 was identified by mass spectrometry (MS) and nuclear magnetic resonance spectroscopy (NMR). The rats were injected with CP-25(6, 12, 24 mg/kg) and orally treated with CP-25 (32, 64, 128 mg/kg), respectively. An high-performance liquid chromatography (HPLC) assay was developed to determine the plasma concentrations of Pae and CP-25. 3. The results of MS and NMR showed that the acylated product was Pae-6'O-benzene sulfonate (CP-25). The plasma levels in oral CP-25 groups were detectable, whereas those of Pae in the oral groups (25 and 50 mg/kg) were undetectable. More specifically, the Cmax values of oral CP-25 were 0.12, 0.19 and 0.44 μg/ml, and the corresponding t1/2β of CP-25 were 1.44, 2.12 and 2.11 h, respectively. In addition, the t1/2β values of intravenous CP-25 were 161.99, 152.81 and 153.76 min, respectively. 4. Compared with the venous pharmacokinetics parameters of Pae, those of the t1/2β, MRT, Vd and CL/F in the CP-25 groups increased noticeably. As expected, compared with oral parameters of Pae, those of t1/2a, t1/2β, AUC, MRT and Vd in the CP-25 group increased obviously. Finally, the absolute bioavailability of Pae and CP-25 were 3.6 and 10.6%, respectively. 5. Our results indicate that CP-25 is characterized by improved absorption, well distribution, lower clearance, long mean residence time, and moderate bioavailability in rats.
Incorporation of Never-Dried Cotton fibers with Methylmethacrylate: A Gateway to Unique Transparent Board-Like Nanocomposites
Creators: name: Fahmy, Tamer Y A
name: Fardous Mobarak
name: Fahmy, Yehia
Publisher: name: figshare
Year: 2017
Subjects: subject: 30301 Chemical Characterisation of Materials
subject: FOS: Chemical sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: 39903 Industrial Chemistry
subject: 30399 Macromolecular and Materials Chemistry not elsewhere classified
subject: 30502 Natural Products Chemistry
subject: 30302 Nanochemistry and Supramolecular Chemistry
subject: Organic Chemistry
subject: 30504 Organic Green Chemistry
subject: 30699 Physical Chemistry not elsewhere classified
subject: 30304 Physical Chemistry of Materials
subject: 30305 Polymerisation Mechanisms
subject: Supramolecular Chemistry
subject: 30307 Theory and Design of Materials
subject: 100706 Nanofabrication, Growth and Self Assembly
subject: FOS: Nanotechnology
subject: 100707 Nanomanufacturing
subject: 100708 Nanomaterials
subject: 100712 Nanoscale Characterisation
subject: 100799 Nanotechnology not elsewhere classified
subject: 60702 Plant Cell and Molecular Biology
subject: FOS: Biological sciences
subject: 60112 Structural Biology (incl. Macromolecular Modelling)

description: For the first time, it is shown that water medium allows dissolved methylmethacrylate monomer to penetrate water-swollen natural nanoporous structure of never-dried cotton fibers (biological cellulose fibers). Unique cellulose copolymer nanocomposites are obtained by green nanotechnology process (solvent is water-ideal green solvent-and reaction conducted at 25ºC). It was found that after only 2 h polymerization the conversion of MMA monomer to polymer was 42.97%, compared to zero polymer conversion in absence of never-dried cotton. Higher water uptake i.e. water retention value (WRV) of the cellulose-PMMA-copolymer nanocomposites prepared from never-dried biological cotton fibers, and microscopic investigations confirmed that the polymer was mostly grafted on the cellulose rather than homopolymer filling the fiber pores. Early products of polymerization e.g. dimmers and trimmers act as spacers and widen the porous structure of cell wall, thus increasing water retention value (WRV). We called this phenomenon "intra-polymerization". As the process of polymerization proceeds, polymerization within cell walls leads to cell wall destruction, increasing WRV of fibers, giving superabsorbent end product. The produced unique biological cotton-PMMA green nanocomposite we discovered find their use in several advanced medical and pharmaceutical fields; as nonwoven pads, bandages or board-like transparent nanocomposites of bending strength up to 955 kg/cm 2 .
Theoretical Insight into the Influences of Molecular Ratios on Stabilities and Mechanical Properties, Solvent Effect of HMX/FOX-7 Cocrystal Explosive
Creators: name: Wei, Yan-Ju
name: Ren, Fu-De
name: Shi, Wen-Jing
name: Zhao, Qi
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Computational Biology

description: A molecular dynamics method was employed to study the binding energies of the selected crystal planes of the 1,3,5,7-tetranitro-1,3,5,7-tetrazacyclooctane/1,1-diamino-2,2-dinitroethylene (HMX/FOX-7) cocrystal in different molecular molar ratios. Mechanical properties, densities, and detonation velocities of the cocrystals in different ratios were estimated. The intermolecular interactions and bond dissociation energies (BDEs) of the N–NO2 bond in the HMX:FOX-7 (1:1) complex were calculated using the B3LYP and MP2(full) methods at the 6–311++G (d,p) and 6–311++G(2df,2p) basis sets. Solvent effects on stability are discussed. The results indicate that HMX/FOX-7 cocrystals prefer cocrystalizing in a 1:1 molar ratio, which has good mechanical properties. The N–NO2 bond becomes strong upon the formation of a complex and the sensitivity of HMX might decrease in cocrystals. The sensitivity change of HMX/FOX-7 originates from not only the formation of intermolecular interaction but also the increment in the N–NO2 BDE. HMX/FOX-7 cocrystals exhibit good detonation performance and meet the requirements of high-density energetic materials. Solvents with low dielectric constants may be chosen to obtain stable HMX/FOX-7 cocrystals.
Assessing the Role of Python Programming Gamified Course on Students’ Knowledge, Skills Performance, Attitude, and Self-Efficacy
Creators: name: Garcia, Manuel
Publisher: name: figshare
Year: 2022
Subjects: Education

description: Coding is widely regarded as a fundamental skill of the 21st century. Yet, there is still a shortage of programmers worldwide which disproportionately affect the innovation goals of many sectors. In this study, we evaluated the installment of a Python programming gamified course in higher education, and measure its effect on students’ knowledge, attitude, self-efficacy, and skills performance. Two sections with 50 students each were randomly assigned to experimental or control groups. After one semester, the experimental group exhibited significantly higher scores in laboratory activities (skills performance) compared to the control group. Furthermore, they demonstrated a significant improvement with reference to attitude and self-efficacy before and after intervention. Therefore, we concluded that the use of a Python programming gamified course was an effective method for students to learn coding and programming concepts. The use and installation of a gamified course in learning other computer programming languages is highly recommended.
Coliquefaction of coal and polystyrene in supercritical water
Creators: name: Shen, Yuan
name: Wu, Haiyan
name: Li, Yan
name: Pan, Zhiyan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: The coliquefaction of coal and polystyrene (PS) in supercritical water (SCW) was carried out in a 50-mL batch stainless steel autoclave reactor, and the effects of the polymer ratio by weight (10–40%), reaction temperature (633.5–703.5 K), and reaction time (30–120 min) were investigated. The main products were analyzed qualitatively by Fourier transform infrared spectroscopy and high-performance liquid chromatography. The results show that polystyrene stimulates coal liquefaction as a hydrogen donor, and the synergistic effects during coliquefaction in SCW were confirmed. The conversion reached a maximum of 62.26% after 60 min at 673.5 K. The phase behavior during coliquefaction was observed in a fused silica capillary reactor using a combined microscope and video recorder system.
Multiple linear regression with compositional response and covariates
Creators: name: Chen, Jiajia
name: Zhang, Xiaoqin
name: Li, Shengjia
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy

description: The standard regression model designed for real space is not suitable for compositional variables; it should be considered, whether the response and/or covariates are of compositional nature. There are usually three types of multiple regression model with compositional variables: Type 1 refers to the case where all the covariates are compositional data and the response is real; Type 2 is the opposite of Type 1; Type 3 relates to the model with compositional response and covariates. There have been some models for the three types. In this paper, we focus on Type 3 and propose multiple linear regression models including model in the simplex and model in isometric log-ratio (ilr) coordinates. The model in the simplex is based on matrix product, which can project a D1-part composition to another D2-part composition, and can deal with different number of parts of compositional variables. Some theorems are given to point out the relationship of parameters between the proposed models. Moreover, the inference for parameters in proposed models is also given. Real example is studied to verify the validity and usefulness of proposed models.
CODIFICAÇÃO DE IMAGENS POR TRANSFORMADAS USANDO UMA TABELA DE ALOCAÇÃO DE BITS ESTENDIDA
Creators: name: Pereira, Olavo Gomes
name: Pelaes@Ufpa.Br
Publisher: name: figshare
Year: 2017
Subjects: subject: 80106 Image Processing
subject: FOS: Computer and information sciences

description: This paper presents a method of images coding, that uses a extended bit allocation table. Usually, the bit allocation tables have the same dimensions of the block used to calculate her transformed. In this method, the table of bit allocation has larger dimensions, that is, for blocks of size 8x8, this table has size 16x16, because it’s certain being taken into account a block of 8x8 and your neighbors. This procedure doesn't introduce a great overhead, once, due to likeness among the 4 tables of 8x8, just a table of size 8x8 and the differences between this table and the others are stored. This method was applied in the image Lena(512x512), using them transformed DCT and LOT, with scalar quantization of Lloid-Max, with rates that vary from 1 to 8 bpp, without entropy code. The results were compared with obtained them for codified images using allocation tables it fastens (8x8), and they presented improvements of until 3,61 dB for LOT.
title: Le camion de Bouboule (Louis Vérilhac) arraisonné par des maquisards du C 6 : maquis Thivollet, Vercors, secteur de Lente, Bouvante, Drôme, juin 1944
Creators: name: Photographe Inconnu
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2019
Subjects: subject: Maquis alpins, Deuxième guerre mondiale, Vercors, 1944, transports

description: Le camion de Bouboule (Louis Vérilhac) arraisonné par des maquisards du C 6: maquis Thivollet, Vercors, secteur de Lente, Bouvante, Drôme, juin 1944
description: Source: GED Campus Condorcet Fonds Yves Pérotin CNRS-IHTP ARC 143 ; 2MAQ_31
Reductive roasting of nickel laterite ore with sodium sulfate for Fe-Ni production. Part I: Reduction/sulfidation characteristics
Creators: name: Rao, Mingjun
name: Li, Guanghui
name: Zhang, Xin
name: Luo, Jun
name: Peng, Zhiwei
name: Jiang, Tao
Publisher: name: Taylor & Francis
Year: 2016
Subjects: Biochemistry
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: The selective reduction of nickel and adequate growth of ferronickel grains are imperative for efficient preparation of ferronickel from nickeliferous laterite ore via the process of direct reduction followed by magnetic separation. In Part I, reduction/sulfidation behaviors of a saprolitic laterite ore in the presence of sodium sulfate were investigated, with an emphasis on thermodynamic analysis, selective reduction/sulfidation ratios and kinetics. To separate the interactions between Ni and Fe, chemical titration analysis was adopted to determine the contents of various Ni and Fe species in the roasted pellets, and a modified equation to assay metallic iron content was proposed.
Reductive Roasting of Nickel Laterite Ore with Sodium Sulfate for Fe-Ni Production. Part I: Reduction/Sulphidation Characteristics
Creators: name: Rao, Mingjun
name: Li, Guanghui
name: Zhang, Xin
name: Luo, Jun
name: Peng, Zhiwei
name: Jiang, Tao
Publisher: name: Taylor & Francis
Year: 2016
Subjects: Biochemistry
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: The selective reduction of nickel and adequate growth of ferronickel grains are imperative for efficient preparation of ferronickel from nickeliferous laterite ore via the process of direct reduction followed by magnetic separation. In Part I, reduction/sulphidation behaviors of a saprolitic laterite ore in the presence of sodium sulfate were investigated, with an emphasis on thermodynamic analysis, selective reduction/sulphidation ratios and kinetics. To separate the interactions between Ni and Fe, chemical titration analysis was adopted to determine the contents of various Ni and Fe species in the roasted pellets, and a modified equation to assay metallic iron content was proposed.
A plasma metabolite score of three eicosanoids predicts incident type 2 diabetes: a prospective study in three independent cohorts.
Creators: name: Tuomisto, Karolina
name: Palmu, Joonatan
name: Long, Tao
name: Watrous, Jeramie D
name: Mercader, Kysha
name: Lagerborg, Kim A
name: Andres, Allen
name: Salmi, Marko
name: Jalkanen, Sirpa
name: Vasan, Ramachandran S
name: Inouye, Michael
name: Havulinna, Aki S
name: Tuomilehto, Jaakko
name: Jousilahti, Pekka
name: Niiranen, Teemu J
name: Cheng, Susan
name: Jain, Mohit
name: Salomaa, Veikko
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Genetics/Genomes/Proteomics/Metabolomics
1506
1879
eicosanoids
inflammation
diabetes mellitus, type 2
epidemiology

description: INTRODUCTION: Peptide markers of inflammation have been associated with the development of type 2 diabetes. The role of upstream, lipid-derived mediators of inflammation such as eicosanoids, remains less clear. The aim of this study was to examine whether eicosanoids are associated with incident type 2 diabetes. RESEARCH DESIGN & METHODS: In the FINRISK (Finnish Cardiovascular Risk Study) 2002 study, a population-based sample of Finnish men and women aged 25-74 years, we used directed, non-targeted liquid chromatography-mass spectrometry to identify 545 eicosanoids and related oxylipins in the participants' plasma samples (n=8292). We used multivariable-adjusted Cox regression to examine associations between eicosanoids and incident type 2 diabetes. The significant independent findings were replicated in the Framingham Heart Study (FHS, n=2886) and DIetary, Lifestyle and Genetic determinants of Obesity and Metabolic syndrome (DILGOM) 2007 (n=3905). Together, these three cohorts had 1070 cases of incident type 2 diabetes. RESULTS: In the FINRISK 2002 cohort, 76 eicosanoids were associated individually with incident type 2 diabetes. We identified three eicosanoids independently associated with incident type 2 diabetes using stepwise Cox regression with forward selection and a Bonferroni-corrected inclusion threshold. A three-eicosanoid risk score produced an HR of 1.56 (95% CI 1.41 to 1.72) per 1 SD increment for risk of incident diabetes. The HR for comparing the top quartile with the lowest was 2.80 (95% CI 2.53 to 3.07). In the replication analyses, the three-eicosanoid risk score was significant in FHS (HR 1.24 (95% CI 1.10 to 1.39, p<0.001)) and directionally consistent in DILGOM (HR 1.12 (95% CI 0.99 to 1.27, p=0.07)). Meta-analysis of the three cohorts yielded a pooled HR of 1.31 (95% CI 1.05 to 1.56). CONCLUSIONS: Plasma eicosanoid profiles predict incident type 2 diabetes and the clearest signals replicate in three independent cohorts. Our findings give new information on the biology underlying type 2 diabetes and suggest opportunities for early identification of people at risk.
MicroRNA-26a/b and their host genes synergistically regulate triacylglycerol synthesis by targeting the INSIG1 gene
Creators: name: Wang, Hui
name: Luo, Jun
name: Zhang, Tianying
name: Tian, Huibin
name: Ma, Yue
name: Xu, Huifen
name: Yao, Dawei
name: J. Loor, Juan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health
subject: Plant Biology
subject: Virology
subject: Computational Biology

description: The microRNA-26 (miR-26) family is known to control adipogenesis in non-ruminants. The genomic loci of miR-26a and miR-26b have been localized in the introns of genes encoding for the proteins of the C-terminal domain RNA polymerase II polypeptide A small phosphatase (CTDSP) family. Insulin-induced gene 1 (INSIG1) encodes a protein with a key role in the regulation of lipogenesis in rodent liver. In the present study, we investigated the synergistic function of the miR-26 family and their host genes in goat mammary epithelial cells (GMEC). Downregulation of miR-26a/b and their host genes in GMEC decreased the expression of genes relate to fatty acid synthesis (PPARG, LXRA, SREBF1, FASN, ACACA, GPAM, LPIN1, DGAT1 and SCD1), triacylglycerol accumulation and unsaturated fatty acid synthesis. Luciferase reporter assays confirmed INSIG1 as a direct target of miR-26a/b. Furthermore, inhibition of the CTDSP family also downregulated the expression of INSIG1. Taken together, our findings highlight a functional association of miR-26a/b, their host genes and INSIG1, and provide new insights into the regulatory network controlling milk fat synthesis in GMEC. The data indicate that targeting this network via nutrition might be important for regulating milk fat synthesis in ruminants.
The microclimatic interaction of a small urban park with its surrounding urban environment: case study of projected impacts of urban densification focusing on heat events in Melbourne
Creators: name: ASIEH MOTAZEDIAN
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: This research aimed to evaluate the microclimate of an urban park and its effect on its surrounding urban environment. It also aimed to determine the optimal design of the urban park to improve human thermal comfort in the future, following urban densification. The results from this study clarified the role and importance of small urban parks in mitigating high temperatures during summer conditions. Results also confirmed that by optimising tree configuration inside the park, and undertaking strategic placement of trees in the surrounding urban canyons, levels of heat stress during heatwave conditions could be reduced to improve human thermal comfort.
Microbial communities form rich extracellular metabolomes that foster metabolic interactions and promote drug tolerance.
Creators: name: Yu, Jason SL
name: Correia-Melo, Clara
name: Zorrilla, Francisco
name: Herrera-Dominguez, Lucia
name: Wu, Mary Y
name: Hartl, Johannes
name: Campbell, Kate
name: Blasche, Sonja
name: Kreidl, Marco
name: Egger, Anna-Sophia
name: Messner, Christoph B
name: Demichev, Vadim
name: Freiwald, Anja
name: Mülleder, Michael
name: Howell, Michael
name: Berman, Judith
name: Patil, Kiran R
name: Alam, Mohammad Tauqeer
name: Ralser, Markus
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Article
/631/326/2565/855
/631/326/22
/13/31
/13/44
/14/34
/14/35
/38/47
/82/80
/96/63
/82/58
article

description: Funder: United Arab Emirates University (UAEU); doi: https://doi.org/10.13039/501100006013
description: Microbial communities are composed of cells of varying metabolic capacity, and regularly include auxotrophs that lack essential metabolic pathways. Through analysis of auxotrophs for amino acid biosynthesis pathways in microbiome data derived from >12,000 natural microbial communities obtained as part of the Earth Microbiome Project (EMP), and study of auxotrophic-prototrophic interactions in self-establishing metabolically cooperating yeast communities (SeMeCos), we reveal a metabolically imprinted mechanism that links the presence of auxotrophs to an increase in metabolic interactions and gains in antimicrobial drug tolerance. As a consequence of the metabolic adaptations necessary to uptake specific metabolites, auxotrophs obtain altered metabolic flux distributions, export more metabolites and, in this way, enrich community environments in metabolites. Moreover, increased efflux activities reduce intracellular drug concentrations, allowing cells to grow in the presence of drug levels above minimal inhibitory concentrations. For example, we show that the antifungal action of azoles is greatly diminished in yeast cells that uptake metabolites from a metabolically enriched environment. Our results hence provide a mechanism that explains why cells are more robust to drug exposure when they interact metabolically.
Post-Selection Inference for Generalized Linear Models With Many Controls
Creators: name: Belloni, Alexandre
name: Chernozhukov, Victor
name: Wei, Ying
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: This article considers generalized linear models in the presence of many controls. We lay out a general methodology to estimate an effect of interest based on the construction of an instrument that immunizes against model selection mistakes and apply it to the case of logistic binary choice model. More specifically we propose new methods for estimating and constructing confidence regions for a regression parameter of primary interest α0, a parameter in front of the regressor of interest, such as the treatment variable or a policy variable. These methods allow to estimate α0 at the root-n rate when the total number p of other regressors, called controls, potentially exceeds the sample size n using sparsity assumptions. The sparsity assumption means that there is a subset of s < n controls, which suffices to accurately approximate the nuisance part of the regression function. Importantly, the estimators and these resulting confidence regions are valid uniformly over s-sparse models satisfying s2log 2p = o(n) and other technical conditions. These procedures do not rely on traditional consistent model selection arguments for their validity. In fact, they are robust with respect to moderate model selection mistakes in variable selection. Under suitable conditions, the estimators are semi-parametrically efficient in the sense of attaining the semi-parametric efficiency bounds for the class of models in this article.
Post-Selection Inference for Generalized Linear Models with Many Controls
Creators: name: Belloni, Alexandre
name: Chernozhukov, Victor
name: Wei, Ying
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: This paper considers generalized linear models in the presence of many controls. We lay out a general methodology to estimate an effect of interest based on the construction of an instrument that immunize against model selection mistakes and apply it to the case of logistic binary choice model. More specifically we propose new methods for estimating and constructing confidence regions for a regression parameter of primary interest α0, a parameter in front of the regressor of interest, such as the treatment variable or a policy variable. These methods allow to estimate α0 at the root-n rate when the total number p of other regressors, called controls, potentially exceed the sample size n using sparsity assumptions. The sparsity assumption means that there is a subset of s < n controls which suffices to accurately approximate the nuisance part of the regression function. Importantly, the estimators and these resulting confidence regions are valid uniformly over s-sparse models satisfying s2log2p = o(n) and other technical conditions. These procedures do not rely on traditional consistent model selection arguments for their validity. In fact, they are robust with respect to moderate model selection mistakes in variable selection. Under suitable conditions, the estimators are semi-parametrically efficient in the sense of attaining the semi-parametric efficiency bounds for the class of models in this paper.
CODIFICAÇÃO DE IMAGENS POR TRANSFORMADAS USANDO UMA T ABELA DE ALOCAÇÃO DE BITS ESTENDIDA
Creators: name: Pereira, Olavo Gomes
Publisher: name: figshare
Year: 2017
Subjects: subject: 80106 Image Processing
subject: FOS: Computer and information sciences

description: This paper presents a method of images coding, that uses a extended bit allocation table. Usually, the bit allocation tables have the same dimensions of the block used to calculate her transformed. In this method, the table of bit allocation has larger dimensions, that is, for blocks of size 8x8, this table has size 16x16, because it’s certain being taken into account a block of 8x8 and your neighbors. This procedure doesn't introduce a great overhead, once, due to likeness among the 4 tables of 8x8, just a table of size 8x8 and the differences between this table and the others are stored. This method was applied in the image Lena(512x512), using them transformed DCT and LOT, with scalar quantization of Lloid-Max, with rates that vary from 1 to 8 bpp, without entropy code. The results were compared with obtained them for codified images using allocation tables it fastens (8x8), and they presented improvements of until 3,61 dB for LOT.
Climate ready vegetation management in the Bay Area: A pilot workshop for land managers
Creators: name: Ackerly, David
Publisher: name: figshare
Year: 2017
Subjects: subject: 50202 Conservation and Biodiversity
subject: FOS: Biological sciences

description: Proceedings of workshop held February 17, 2017, to address conservation and management implications of vegetation responses to climate change.
Un volumen reúne los cuentos de Cortázar
Creators: name: Indeterminado
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021
Subjects: Obras Completas de Julio Cortázar

description: Edición de "Obras Completas I – Cuentos" de Julio Cortázar por Círculo de Lectores-Galaxia Gutenberg, proyecto dirigido por Saúl Yurkievich.
description: Tipo de publicación: Periódico digital
description: Título de la publicación: Diari de Tarragona
description: Periodicidad: Diario
description: Source: Num.Ref. : JC-DY-CAR-04.047
description: Source: Localización del archivo: Centre de Recherches Latino-Américaines (CRLA–Archivos, ITEM UMR8132). MSHS - Bât. A5, 1er étage 5 rue Théodore Lefebvre - TSA21103. 86073 Poitiers cedex 9.
Windows of developmental sensitivity to social media.
Creators: name: Orben, Amy
name: Przybylski, Andrew K
name: Blakemore, Sarah-Jayne
name: Kievit, Rogier A
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Article
/631/477/2811
/692/308
article

description: Funder: Jacobs Foundation; doi: https://doi.org/10.13039/501100003986
description: Funder: University of Cambridge; doi: https://doi.org/10.13039/501100000735
description: The relationship between social media use and life satisfaction changes across adolescent development. Our analyses of two UK datasets comprising 84,011 participants (10-80 years old) find that the cross-sectional relationship between self-reported estimates of social media use and life satisfaction ratings is most negative in younger adolescents. Furthermore, sex differences in this relationship are only present during this time. Longitudinal analyses of 17,409 participants (10-21 years old) suggest distinct developmental windows of sensitivity to social media in adolescence, when higher estimated social media use predicts a decrease in life satisfaction ratings one year later (and vice-versa: lower estimated social media use predicts an increase in life satisfaction ratings). These windows occur at different ages for males (14-15 and 19 years old) and females (11-13 and 19 years old). Decreases in life satisfaction ratings also predicted subsequent increases in estimated social media use, however, these were not associated with age or sex.
Adsorption of anionic dyes from water by thermostable supramolecular hydrogel
Creators: name: Chen, Xu-Man
name: Zhang, Ying-Ming
name: Liu, Yu
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Plant Biology
subject: FOS: Biological sciences

description: A supramolecular hydrogel was successfully constructed by the noncovalent association of cucurbit[8]uril (CB[8]) with a tetraphenylethylene (TPE) derivative bearing four monocharged viologens (TPE-4Q). Due to the attractive photophysical behaviours of TPE and its rigid complexation with CB[8], the obtained hydrogel emits bright orange fluorescence and is highly thermostable even at 200 °C. Rheological analyses and microscopic investigations jointly confirm that the supramolecular hydrogel possesses good rheological properties and well-organised lamellar structures. Significantly, the assembly/disassembly process of this supramolecular hydrogel can be efficiently modulated by several external stimuli, including pH, mechanical force and competitive guests. Moreover, as investigated by UV/Vis and fluorescence titrations, this two-dimensional self-assembly can specifically adsorb π-conjugated anionic dyes in water with high adsorption efficiency, mainly through the π-stacking interaction with TPE backbones and the electrostatic interaction with monocharged viologen sites.
Periodic synchronisation of dengue epidemics in Thailand over the last 5 decades driven by temperature and immunity.
Creators: name: García-Carreras, Bernardo
name: Yang, Bingyi
name: Grabowski, Mary K
name: Sheppard, Lawrence W
name: Huang, Angkana
name: Salje, Henrik
name: Clapham, Hannah Eleanor
name: Iamsirithaworn, Sopon
name: Doung-Ngern, Pawinee
name: Lessler, Justin
name: Cummings, Derek AT
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Research Article
Medicine and health sciences
Biology and life sciences
Research and analysis methods
People and places
Earth sciences

description: The spatial distribution of dengue and its vectors (spp. Aedes) may be the widest it has ever been, and projections suggest that climate change may allow the expansion to continue. However, less work has been done to understand how climate variability and change affects dengue in regions where the pathogen is already endemic. In these areas, the waxing and waning of immunity has a large impact on temporal dynamics of cases of dengue haemorrhagic fever. Here, we use 51 years of data across 72 provinces and characterise spatiotemporal patterns of dengue in Thailand, where dengue has caused almost 1.5 million cases over the last 30 years, and examine the roles played by temperature and dynamics of immunity in giving rise to those patterns. We find that timescales of multiannual oscillations in dengue vary in space and time and uncover an interesting spatial phenomenon: Thailand has experienced multiple, periodic synchronisation events. We show that although patterns in synchrony of dengue are similar to those observed in temperature, the relationship between the two is most consistent during synchronous periods, while during asynchronous periods, temperature plays a less prominent role. With simulations from temperature-driven models, we explore how dynamics of immunity interact with temperature to produce the observed patterns in synchrony. The simulations produced patterns in synchrony that were similar to observations, supporting an important role of immunity. We demonstrate that multiannual oscillations produced by immunity can lead to asynchronous dynamics and that synchrony in temperature can then synchronise these dengue dynamics. At higher mean temperatures, immune dynamics can be more predominant, and dengue dynamics more insensitive to multiannual fluctuations in temperature, suggesting that with rising mean temperatures, dengue dynamics may become increasingly asynchronous. These findings can help underpin predictions of disease patterns as global temperatures rise.
Synthesis, crystal structures, and properties of two novel compounds containing triphosphonate groups
Creators: name: Guan, Lei
name: Wang, Ying
Publisher: name: Taylor & Francis
Year: 2016
Subjects: Biochemistry
Physical Sciences not elsewhere classified
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: Two novel phosphonate compounds (H2L)·Hphen (1) and [Ca(HL)(H2O)]n·3.5nH2O (2) (L = N(CH2PO3H)33−) were synthesized under hydrothermal conditions. Compound 1 features a chain structure in the ac plane, where HL2− anions are interconnected through sharing hydrogen ions to form a 1D zigzag type. Compound 2 features a layered structure in the ab plane, which has inorganic calcium cores with the organic part of the phosphonate anions being encircling the cores through coordination actions. The free water molecules can form hydrogen bonds with the coordinated water molecules and phosphonate oxygen atoms, which are able to link the adjacent layers to generate a 3D network structure. In addition, the thermal stability and photoluminescence properties were also studied.
VCIOM-SPUTNIK Poll: November 2021
Creators: name: VCIOM (Russian Public Opinion Research Center)
Publisher: name: Roper Center for Public Opinion Research
Year: 2022

description: President of Russia approval (1); Prime Minister approval (1); State Duma of Russia (2); political party preference (2); mass protests (2); Internet usage (1); watch TV (1); trade unions (1); judicial system (1); Russian Orthodox church (1); personal financial situation (2); employment (2); sources of income (1); most important problems (5); rise in prices, inflation (2); Russian ruble and US dollar exchange rate fluctuations (3); unemployment (2); take out loans (2); spend or save money (1); savings (1); economic policy (1); social policy (1); foreign policy (1); direction of country (1); life satisfaction (2).
Enhancement of oral insulin bioavailability: in vitro and in vivo assessment of nanoporous stimuli-responsive hydrogel microparticles
Creators: name: Ahmad, Naveed
name: Cairul Iqbal Mohd Amin, Mohd
name: Ismail, Ismanizan
name: Buang, Fhataheya
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: Objective: Oral insulin administration suffers gastrointestinal tract (GIT) degradation and inadequate absorption from the intestinal epithelium resulting in poor bioavailability. This study entails in vitro and in vivo assessment of stimuli-responsive hydrogel microparticles (MPs) in an attempt to circumvent GI barrier and enhance oral insulin bioavailability. Methods: Bacterial cellulose-g-poly(acrylic acid) (BC-g-P(AA)) hydrogel MPs were evaluated for morphology, swelling, entrapment efficiency (EE), in vitro insulin release and enzyme inhibition. The ex vivo mucoadhesion, insulin degradation and transport were investigated in excised intestinal tissues. The effect of MPs on paracellular transport was studied in Caco-2/HT29-MTX monolayers. The in vivo hypoglycemic effect and pharmacokinetics of insulin-loaded MPs were investigated in diabetic rats. Results: Hydrogel MPs efficiently entrapped insulin (EE up to 84%) and exhibited pH-responsive in vitro release. The MPs decreased the proteolytic activity of trypsin (up to 60%). Insulin transport across monolayers was increased up to 5.9-times by MPs. Histological assessment of GI tissues confirmed the non-toxicity of MPs. Orally administered insulin-loaded MPs showed higher hypoglycemic effect as compared to insulin solution and enhanced relative oral bioavailability of insulin up to 7.45-times. Conclusion: These findings suggest that BC-g-P(AA) MPs are promising biomaterials to overcome the barriers of oral insulin delivery and enhancing its bioavailability.
Catalytic improvement and structural analysis of atrazine chlorohydrolase by site-saturation mutagenesis
Creators: name: Guo, Yuan
name: Zhao, Panjie
name: Zhang, Wenhao
name: Li, Xiaolong
name: Chen, Xiwen
name: Chen, Defu
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: To improve the catalytic activity of atrazine chlorohydrolase (AtzA), amino acid residues involved in substrate binding (Gln71) and catalytic efficiency (Val12, Ile393, and Leu395) were targeted to generate site-saturation mutagenesis libraries. Seventeen variants were obtained through Haematococcus pluvialis-based screening, and their specific activities were 1.2–5.2-fold higher than that of the wild type. For these variants, Gln71 tended to be substituted by hydrophobic amino acids, Ile393 and Leu395 by polar ones, especially arginine, and Val12 by alanine, respectively. Q71R and Q71M significantly decreased the Km by enlarging the substrate-entry channel and affecting N-ethyl binding. Mutations at sites 393 and 395 significantly increased the kcat/Km, probably by improving the stability of the dual β-sheet domain and the whole enzyme, owing to hydrogen bond formation. In addition, the contradictory relationship between the substrate affinity improvement by Gln71 mutation and the catalytic efficiency improvement by the dual β-sheet domain modification was discussed. Structrual modification in AtzA variants.
The First VHE Activity of OJ 287 and the Extragalactic Background Light
Creators: name: Yadav, Sameer
name: Kushwaha, Pankaj
Publisher: name: arXiv
Year: 2024
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The BL Lacertae (BL Lac) object OJ 287 underwent an intense X-ray activity phase, exhibiting its brightest recorded X-ray flare in 2016-2017, characterized by much softer X-ray spectra and, concurrently, its first-ever recorded very-high-energy (VHE) emission (100--560 GeV), reported by the VERITAS observatory. Broadband spectral energy distribution reveals a new jet emission component similar to high-synchrotron-peaked BL Lac objects, thereby implying the soft X-ray spectrum for the synchrotron emission. Using the advantage of simultaneous X-ray and VHE spectral information, as well as the source being a low-synchrotron-peaked BL Lac object, we systematically explored the extragalactic background light (EBL) spectrum by demanding that the VHE spectrum cannot be harder than the X-ray spectrum. We used three different phenomenological forms of the EBL spectral shape (power-law, parabola, and polynomial) motivated by current constraints on the EBL with the Bayesian Monte Carlo approach to infer the credible EBL range. Our study favors an almost flat power-law spectral shape and is consistent with previous studies. The other spectral forms capable of capturing curvature though result in a better statistics value; the improvement is statistically insignificant given the additional parameters.
description: 13 pages, 4 figures, 2 tables
title: Quelles interventions infirmières non pharmacologiques permettent une meilleure gestion des douleurs postopératoires chez les personnes âgées ne présentant pas de troubles cognitifs en salle de réveil ?
title: Quelles interventions infirmières non pharmacologiques permettent une meilleure gestion des douleurs postopératoires chez les personnes âgées ne présentant pas de troubles cognitifs en salle de réveil ?
titleType: AlternativeTitle
Creators: name: Oliveira De Matos, Tania
name: Ranghino, Paola
Publisher: name: Unknown
Year: 0
Subjects: subject: Douleur post-opéraoire
subject: Personne âgée
subject: Rôle infirmier
subject: Traitement non-pharmacologique
subject: Médecine alternative

description: La difficulté que représente la gestion de la douleur aiguë chez la personne âgée est un phénomène connu depuis plusieurs années. Dans des services comme la salle de réveil, les infirmières se retrouvent souvent seules pour gérer les douleurs postopératoires, avec pour unique outil les prescriptions médicales. Or parfois, les traitements médicamenteux ne sontpas suffisants pour soulager la douleur et ils entraînent souvent des effets secondaires importants chez cette patientèle. Le rôle autonome des infirmiers leur permet de mettre en place des interventions non pharmacologiques en fonction de leur jugement clinique, étant donné qu’elles peuvent être exécutées sans ordonnance médicale. De plus, ce genre d’intervention comporte peu de risque pour les patients et est souvent peu onéreuse.