title: ÐÐ¾Ð»ÑÑÐµÐ½Ð¸Ðµ Ð¸ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÐ²Ð¾Ð¹ÑÑÐ² Ð³Ð¸Ð±ÑÐ¸Ð´Ð½ÑÑ Ð²Ð¾Ð»Ð¾ÐºÐ¾Ð½ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ñ Ð¸ÑÐ¾Ð·Ð°Ð½Ð° Ð¸ Ð¿Ð¾Ð»Ð¸ (L-Ð»Ð°ÐºÑÐ¸Ð´Ð°) Ð´Ð»Ñ ÐºÑÐ°Ð½Ð¸Ð¾Ð¿Ð»Ð°ÑÑÐ¸ÐºÐ¸
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Obtaining and researching the properties of hybrid fibers based on chitosan and poly(L-lactide) for cranioplasty
Creators: name: ÐÐµÐ»ÐµÐ½ÑÐºÐ°Ñ, ÐÐ¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: ÑÐºÐ°Ð½ÐµÐ²Ð°Ñ Ð¸Ð½Ð¶ÐµÐ½ÐµÑÐ¸Ñ
ÐºÑÐ°Ð½Ð¸Ð¾Ð¿Ð»Ð°ÑÑÐ¸ÐºÐ°
Ð²Ð¾ÑÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð¸Ðµ ÐºÐ¾ÑÑÐ½Ð¾Ð¹ ÑÐºÐ°Ð½Ð¸
Ñ Ð¸ÑÐ¾Ð·Ð°Ð½
Ð¿Ð¾Ð»Ð¸Ð»Ð°ÐºÑÐ¸Ð´
Ð±Ð¸Ð¾Ð´ÐµÐ³ÑÐ°Ð´Ð¸ÑÑÐµÐ¼ÑÐµ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ñ
Ð²Ð¾Ð»Ð¾ÐºÐ½Ð°
Ð¼Ð¾ÐºÑÐ¾Ðµ ÑÐ¾ÑÐ¼Ð¾Ð²Ð°Ð½Ð¸Ðµ
Ð¼ÐµÑ Ð°Ð½Ð¸ÑÐµÑÐºÐ¸Ðµ ÑÐ²Ð¾Ð¹ÑÑÐ²Ð° Ð²Ð¾Ð»Ð¾ÐºÐ¾Ð½
ÐºÐ¾Ð¼Ð¿Ð¾Ð·Ð¸ÑÐ¸Ð¾Ð½Ð½ÑÐµ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ñ
tissue engineering
cranioplasty
regeneration bone tissue
chitosan
polylactic acid
biodegradable materials
fibers
wet spinning
mechanical properties of fibers
composite materials

description: Ð Ð°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¿Ð¾Ð»ÑÑÐµÐ½Ð¸Ñ Ð¸ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐ²Ð¾Ð¹ÑÑÐ² Ð³Ð¸Ð±ÑÐ¸Ð´Ð½ÑÑ Ð½Ð¸ÑÐµÐ¹ Ð¸Ð· ÑÐ¸ÑÐ¾Ð·Ð°Ð½Ð° Ð¸ Ð¿Ð¾Ð»Ð¸(L-Ð»Ð°ÐºÑÐ¸Ð´Ð°), ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐµ ÑÐ¿Ð¾ÑÐ¾Ð±Ð° Ð¿Ð¾Ð»ÑÑÐµÐ½Ð¸Ñ Ð°ÑÐ¼Ð¸ÑÑÑÑÐµÐ¹ ÑÐºÐ°Ð½Ð¸ Ð´Ð»Ñ Ð±Ð¸Ð¾ÑÐ¾Ð²Ð¼ÐµÑÑÐ¸Ð¼Ð¾Ð³Ð¾ Ð¸ Ð±Ð¸Ð¾ÑÐµÐ·Ð¾ÑÐ±Ð¸ÑÐµÐ¼Ð¾Ð³Ð¾ ÐºÐ¾Ð¼Ð¿Ð¾Ð·Ð¸ÑÐ¸Ð¾Ð½Ð½Ð¾Ð³Ð¾ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ð° Ñ ÑÐµÐ»ÑÑ ÐµÐ³Ð¾ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ñ Ð² ÐºÑÐ°Ð½Ð¸Ð¾Ð¿Ð»Ð°ÑÑÐ¸ÐºÐµ. ÐÐ¾Ð»ÑÑÐµÐ½Ñ Ð¿Ð¾Ð»Ð¸ÑÐ¸Ð»Ð°Ð¼ÐµÐ½ÑÐ½ÑÐµ Ð½Ð¸ÑÐ¸ Ð¸Ð· ÑÐ°ÑÑÐ²Ð¾ÑÐ° ÑÐ¸ÑÐ¾Ð·Ð°Ð½Ð° ÐºÐ¾Ð°Ð³ÑÐ»ÑÑÐ¸Ð¾Ð½Ð½ÑÐ¼ Ð¼ÐµÑÐ¾Ð´Ð¾Ð¼, ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½ ÑÐ¿Ð¾ÑÐ¾Ð± Ð¸Ñ Ð¾Ð±ÑÐ°Ð±Ð¾ÑÐºÐ¸ ÑÐ°ÑÑÐ²Ð¾ÑÐ°Ð¼Ð¸ Ð¿Ð¾Ð»Ð¸(L-Ð»Ð°ÐºÑÐ¸Ð´Ð°) ÑÐ°Ð·Ð»Ð¸ÑÐ½Ð¾Ð¹ ÐºÐ¾Ð½ÑÐµÐ½ÑÑÐ°ÑÐ¸Ð¸. ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½Ñ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐµÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ ÑÐ²Ð¾Ð¹ÑÑÐ² ÑÐ°ÑÑÐ²Ð¾ÑÐ¾Ð² Ñ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÐ¼ ÑÐ¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸ÐµÐ¼ Ð¿Ð¾Ð»Ð¸(L-Ð»Ð°ÐºÑÐ¸Ð´Ð°) Ð² ÑÐ»Ð¾ÑÐ¾ÑÐ¾ÑÐ¼Ðµ, Ð¿Ð¾ÐºÐ°Ð·Ð°Ð½Ð¾, ÑÑÐ¾ Ð² ÑÐ¸ÑÐ¾ÐºÐ¾Ð¼ Ð´Ð¸Ð°Ð¿Ð°Ð·Ð¾Ð½Ðµ ÑÐºÐ¾ÑÐ¾ÑÑÐµÐ¹ ÑÐ´Ð²Ð¸Ð³Ð°, Ð¾Ñ 0.1 Ð´Ð¾ 2000 Ñ-1, ÑÐ°ÑÑÐ²Ð¾ÑÑ Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÑÑÑ ÑÐ¾Ð±Ð¾Ð¹ Ð½ÐµÐ½ÑÑÑÐ¾Ð½Ð¾Ð²ÑÐºÐ¸Ðµ Ð¶Ð¸Ð´ÐºÐ¾ÑÑÐ¸. ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½Ñ Ð¼ÐµÑÐ°Ð½Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¸ÑÐ¿ÑÑÐ°Ð½Ð¸Ñ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ Ð³Ð¸Ð±ÑÐ¸Ð´Ð½ÑÑ Ð²Ð¾Ð»Ð¾ÐºÐ¾Ð½, Ð² ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ ÐºÐ¾ÑÐ¾ÑÑÑ Ð±ÑÐ» Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½ Ð¾Ð¿ÑÐ¸Ð¼Ð°Ð»ÑÐ½ÑÐ¹ Ð´Ð¸Ð°Ð¿Ð°Ð·Ð¾Ð½ ÐºÐ¾Ð½ÑÐµÐ½ÑÑÐ°ÑÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸(L-Ð»Ð°ÐºÑÐ¸Ð´Ð°) Ð´Ð»Ñ Ð¿Ð¾Ð²ÐµÑÑÐ½Ð¾ÑÑÐ½Ð¾Ð¹ Ð¾Ð±ÑÐ°Ð±Ð¾ÑÐºÐ¸ Ð½Ð¸ÑÐµÐ¹.ÐÐ»Ñ Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ Ð±Ð¸Ð¾ÑÐ¾Ð²Ð¼ÐµÑÑÐ¸Ð¼Ð¾ÑÑÐ¸ Ð³Ð¸Ð±ÑÐ¸Ð´Ð½ÑÑ Ð½Ð¸ÑÐµÐ¹ Ð±ÑÐ»Ð¸ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ñ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÑ in vivo. ÐÐ¾ÐºÐ°Ð·Ð°Ð½Ð¾ Ð¾ÑÑÑÑÑÑÐ²Ð¸Ðµ Ð²Ð¾ÑÐ¿Ð°Ð»Ð¸ÑÐµÐ»ÑÐ½Ð¾Ð³Ð¾ Ð¾ÑÐ²ÐµÑÐ° Ð¸ ÑÐµÐ·Ð¾ÑÐ±ÑÐ¸Ð¸ Ð² ÐºÐ¾ÑÐ¾ÑÐºÐ¸Ðµ ÑÑÐ¾ÐºÐ¸, ÑÑÐ¾ Ð²Ð°Ð¶Ð½Ð¾ Ð´Ð»Ñ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð² ÐºÐ¾ÑÑÐ½Ð¾Ð¹ Ð¿Ð»Ð°ÑÑÐ¸ÐºÐµ. ÐÐ¾Ð»ÑÑÐµÐ½Ð° ÑÐºÐ°Ð½Ñ, Ð°ÑÐ¼Ð¸ÑÑÑÑÐ¸Ð¹ ÑÐ»ÐµÐ¼ÐµÐ½Ñ ÐºÐ¾Ð¼Ð¿Ð¾Ð·Ð¸ÑÐ¸Ð¾Ð½Ð½Ð¾Ð³Ð¾ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ð° Ð´Ð»Ñ ÐºÑÐ°Ð½Ð¸Ð¾Ð¿Ð»Ð°ÑÑÐ¸ÐºÐ¸, Ð° ÑÐ°ÐºÐ¶Ðµ ÐºÐ¾Ð¼Ð¿Ð¾Ð·Ð¸ÑÐ¸Ð¾Ð½Ð½ÑÐ¹ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð» Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð±Ð¸Ð¾ÑÐµÐ·Ð¾ÑÐ±Ð¸ÑÑÐµÐ¼Ð¾Ð¹ ÑÐºÐ°Ð½Ð¸ Ð¸Ð· Ð³Ð¸Ð±ÑÐ¸Ð´Ð½ÑÑ Ð²Ð¾Ð»Ð¾ÐºÐ¾Ð½ Ð¸ Ð±Ð¸Ð¾ÑÐµÐ·Ð¾ÑÐ±Ð¸ÑÑÐµÐ¼Ð¾Ð³Ð¾ Ð¿Ð¾Ð»Ð¸Ð»Ð°ÐºÑÐ¸Ð´Ð½Ð¾Ð³Ð¾ ÑÐ²ÑÐ·ÑÑÑÐµÐ³Ð¾.
description: The work is devoted to the production and study of the properties of hybridyarns from chitosan and poly(L-lactide), the development of a method for producing reinforcing fabric for biocompatible and bioresorbable composite material with the aim of its use in cranioplasty. Multifilament yarns were obtained from a chitosan solution by the coagulation method, and a method was developed for treating them with poly(L-lactide) solutions of various concentrations. Studies of the rheological properties of solutions with dif-ferent contents of poly(L-lactide) in chloroform were carried out; it was shown that in a wide range of shear rates, from 0.1 to 2000 s-1, the solutions are non-Newtonian flu-ids. The mechanical tests of the obtained hybrid fibers were carried out, as a result of which the optimal range of concentrations of poly(L-lactide) was determined for the surface treatment of filaments.In vivoexperiments were performed to study the bio-compatibility of hybrid strands. The absence of an inflammatory response and resorp-tion in a short time was shown, which is important for use in bone grafting. The fabric obtained is a reinforcing element of a composite material for cranio-plasty, as well as a composite material based on bioresorbable tissue from hybrid fibers and a bioresorbable polylactide binder.