cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Download Pdf Mémento 100% visuel de la pharmacologie en IFSI  - 150 cartes mentales
Creators: name: Moore
Publisher: name: Zenodo
Year: 2024

description: Mémento 100% visuel de la pharmacologie en IFSI - 150 cartes mentales pan Anne Barrau

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Caractéristiques

Mémento 100% visuel de la pharmacologie en IFSI - 150 cartes mentales

Anne Barrau

Nb. de pages: 192

Format: Pdf, ePub, MOBI, FB2

ISBN: 9782311664355

Editeur: Vuibert

Date de parution: 2022

 

 

 

Google book downloader pour ipad Mémento 100% visuel de la pharmacologie en IFSI - 150 cartes mentales en francais iBook ePub PDB

 

Overview

Ce livre de poche tout en couleurs synthétise en 150 fiches très visuelles ou "mind map", tout ce qu'il faut retenir en pharmacologie et thérapeutiques pendant ses trois années d'études en IFSI. Elles sont classées en grands thèmes issus du référentiel infirmier : les grands principes de chimie ; la pharmacodynamie et la pharmacocinétique ; les dosages, préparations et dilutions ; les principales familles thérapeutiques avec les sous-familles ; la prescription chez les enfants et les personnes âgées ; la responsabilité infirmière : prescription, réglementation, préparation, collaboration avec l'aide-soignant, etc. les autres moyens thérapeutiques. Rédigé par une ancienne cadre de santé formatrice et relu par un pharmacien, ce mémento, facile d'utilisation, sera utile pour réviser les UE 2.1 et 4.4 et 5.5 et pendant les stages en structures d'accueil et à l'hôpital.
Epithelial barrier assembly requires coordinated activity of multiple domains of the tight junction protein ZO-1
Creators: name: Tanner Beam, M.
name: Rodgers, Laurel S.
name: Anderson, James M.
name: Fanning, Alan S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Tight junctions (TJs) regulate the paracellular movement of ions, macromolecules and immune cells across epithelia. Zonula occludens (ZO)-1 is a multi-domain polypeptide required for the assembly of TJs. MDCK II cells lacking ZO-1, and its homolog ZO-2, have three distinct phenotypes: reduced localization of occludin and some claudins to the TJs, increased epithelial permeability, and expansion of the apical actomyosin contractile array found at the apical junction complex (AJC). However, it is unclear exactly which ZO-1 binding domains are required to coordinate these activities. We addressed this question by examining the ability of ZO-1 domain-deletion transgenes to reverse the effects of ZO depletion. We found that the SH3 domain and the U5 motif are required to recruit ZO-1 to the AJC and that localization is a prerequisite for normal TJ and cytoskeletal organization. The PDZ2 domain is not required for localization of ZO-1 to the AJC, but is necessary to establish the characteristic continuous circumferential band of ZO-1, occludin and claudin-2. PDZ2 is also required to establish normal permeability, but is not required for normal cytoskeletal organization. Finally, our results demonstrate that PDZ1 is crucial for the normal organization of both the TJ and the AJC cytoskeleton. Our results establish that ZO-1 acts as a true scaffolding protein and that the coordinated activity of multiple domains is required for normal TJ structure and function.
(2810) Gertrude Ellen W McGowan
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Deep Dynamic Boosted Forest
Creators: name: Wang, Haixin
name: Ren, Xingzhang
name: Sun, Jinan
name: Ye, Wei
name: Chen, Long
name: Yu, Muzhi
name: Zhang, Shikun
Publisher: name: arXiv
Year: 2018
Subjects: subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: Random forest is widely exploited as an ensemble learning method. In many practical applications, however, there is still a significant challenge to learn from imbalanced data. To alleviate this limitation, we propose a deep dynamic boosted forest (DDBF), a novel ensemble algorithm that incorporates the notion of hard example mining into random forest. Specically, we propose to measure the quality of each leaf node of every decision tree in the random forest to determine hard examples. By iteratively training and then removing easy examples from training data, we evolve the random forest to focus on hard examples dynamically so as to balance the proportion of samples and learn decision boundaries better. Data can be cascaded through these random forests learned in each iteration in sequence to generate more accurate predictions. Our DDBF outperforms random forest on 5 UCI datasets, MNIST and SATIMAGE, and achieved state-of-the-art results compared to other deep models. Moreover, we show that DDBF is also a new way of sampling and can be very useful and efficient when learning from imbalanced data.
description: Accepted for ACML 2020 (12th Asian Conference on Machine Learning, November 18-20 2020)
Additional file 1 of Anopheline diversity in urban and peri-urban malaria foci: comparison between alternative traps and seasonal effects in a city in the Western Brazilian Amazon
Creators: name: Meireles, Anne Caroline Alves
name: da Silva, Lucas Rosendo
name: Simplício, Marlon Ferreira
name: de Lima, Alzemar Alves
name: Rios, Flávia Geovana Fontineles
name: de Menezes, Carla Augusta
name: Feitoza, Luiz Henrique Maciel
name: Julião, Genimar Rebouças
Publisher: name: figshare
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1. Site Selection Criteria. Table S1. Number of malaria cases in the urban and peri-urban localities from the city of Porto Velho, between 2015-2017. Figure S1. Location of 25 sites sampled for anopheline presence in Porto Velho, Rondônia, Brazil. Table S2. Details on 25 sites where anopheline presence was recorded, and selected sites in bold.
Insulin receptor isoform switching in intestinal stem cells, progenitors, differentiated lineages and tumors: evidence that IR-B limits proliferation
Creators: name: Simmons, James G.
name: Santoro, M. Agostina
name: Lund, P. Kay
name: Andres, Sarah F.
name: Mah, Amanda T.
name: Van Landeghem, Laurianne
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Despite evidence for the impact of insulin on intestinal epithelial physiology and pathophysiology, the expression patterns, roles, and regulation of insulin receptor (IR) and IR isoforms in the intestinal epithelium are not well characterized. IR-A is thought to mediate the proliferative effects of insulin or insulin growth factors (IGFs) in fetal or cancer cells. IR-B is considered to be the metabolic receptor for insulin in specialized tissues. This study used a novel Sox9-EGFP reporter mouse that permits isolation of intestinal epithelial stem cells (IESCs), progenitors, enteroendocrine cells and differentiated lineages, the ApcMin/+ mouse model of precancerous adenoma and normal human intestinal and colorectal cancer (CRC) cell lines. We tested the hypothesis that there is differential expression of IR-A or IR-B in stem and tumor cells versus differentiated intestinal epithelial cells (IECs) and that IR-B impacts cell proliferation. Our findings provide evidence that IR-B expression is significantly lower in highly proliferative IESCs and progenitor cells versus post-mitotic, differentiated IECs and in subconfluent and undifferentiated versus differentiated Caco-2 cells. IR-B is also reduced in ApcMin/+ tumors and highly tumorigenic CRC cells. These differences in IR-B were accompanied by altered levels of mRNAs encoding muscleblind-like 2 (MBNL2), a known regulator of IR alternative splicing. Forced IR-B expression in subconfluent and undifferentiated Caco-2 cells reduced proliferation and increased biomarkers of differentiation. Our findings indicate that the impact of insulin on different cell types in the intestinal epithelium might differ depending on relative IR-B∶ IR-A expression levels and provide new evidence for the roles of IR-B to limit proliferation of CRC cells.
ATLAS DE CIRUGIA DE TORAX leer pdf
Creators: name: Swing
Publisher: name: Zenodo
Year: 2024

description: ATLAS DE CIRUGIA DE TORAX de MARK K. FERGUSON

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Ficha técnica

ATLAS DE CIRUGIA DE TORAX

MARK K. FERGUSON

Número de páginas: 295

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9789588473277

Editorial: AMOLCA

Año de edición: 2009

 

 

 

 

 

Descargar libros completos en pdf. ATLAS DE CIRUGIA DE TORAX 9789588473277 de MARK K. FERGUSON (Spanish Edition)

 

Overview
Additional file 2 of Anopheline diversity in urban and peri-urban malaria foci: comparison between alternative traps and seasonal effects in a city in the Western Brazilian Amazon
Creators: name: Meireles, Anne Caroline Alves
name: da Silva, Lucas Rosendo
name: Simplício, Marlon Ferreira
name: de Lima, Alzemar Alves
name: Rios, Flávia Geovana Fontineles
name: de Menezes, Carla Augusta
name: Feitoza, Luiz Henrique Maciel
name: Julião, Genimar Rebouças
Publisher: name: figshare
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 2. Residual Diagnostics, Model Validation, and Temporal Autocorrelation Analyses - Anopheline Abundance Data.
Questionnaire Enquête SOSP-FR
Creators: name: , Charrier
name: Béchec, Le
Publisher: name: Zenodo
Year: 2020
Subjects: sciences ouverte ; questionnaire ; outils numériques ; enquête

description: Questionnaire de l'enquête SOSP-FR menée par l'URFIST de Lyon et élaboré par Claire Denecker, Conservatrice des bibliothèques, Université de Lyon, URFIST de Lyon, Philippe Charrier, Ingénieur d’études, Université de Lyon, URFIST de Lyon, Gabriel Gallezot, Maître de conférences, Université Côte d’Azur, URFIST Méditerranée, Aline Bouchard, Conservatrice des bibliothèques, École des Chartes, URFIST de Paris, Stéphanie Rennes, Ingénieure d’études INRAE, Doctorante Université de Strasbourg.fr
(2806) Hannah Hopkinson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
DOWNLOAD [PDF] {EPUB} Calling of Light by Lori M. Lee
Creators: name: Martin
Publisher: name: Zenodo
Year: 2024

description: Calling of Light by Lori M. Lee

 

 

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Calling of Light

Lori M. Lee

Page: 352

Format: pdf, ePub, mobi, fb2

ISBN: 9781645676201

Publisher: Page Street Publishing

 

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Best book torrent sites Download it here and read it on your Kindle device. Publication Date of this book PDF Calling of Light by Lori M. Lee EPUB Download. HQ EPUB/MOBI/KINDLE/PDF/Doc Read PDF Calling of Light by Lori M. Lee EPUB Download ISBN. Synopsis PDF Calling of Light by Lori M. Lee EPUB Download zip file. PDF Calling of Light by Lori M. Lee EPUB Download You will be able to download it easily. You can download your books fast EPUB Calling of Light By Lori M. Lee PDF Download. EPUB Calling of Light By Lori M. Lee PDF Download review, torrent download locations.

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Calling of Light EPUB PDF Download Read Lori M. Lee Plot, ratings, reviews. Share the link to download ebook EPUB Calling of Light By Lori M. Lee PDF Download Kindle edition free. Novels - upcoming EPUB Calling of Light By Lori M. Lee PDF Download. EPUB Calling of Light By Lori M. Lee PDF Download Share link here and get free ebooks to read online. Read without downloading EPUB Calling of Light By Lori M. Lee PDF Download Book Format PDF EPUB Kindle.
On the Yang-Baxter Poisson algebra in non-ultralocal integrable systems
Creators: name: Bazhanov, Vladimir V.
name: Kotousov, Gleb A.
name: Lukyanov, Sergei L.
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: A common approach to the quantization of integrable models starts with the formal substitution of the Yang-Baxter Poisson algebra with its quantum version. However it is difficult to discern the presence of such an algebra for the so-called non-ultralocal models. The latter includes the class of non-linear sigma models which are most interesting from the point of view of applications. In this work, we investigate the emergence of the Yang-Baxter Poisson algebra in a non-ultralocal system which is related to integrable deformations of the Principal Chiral Field.
description: 29 pages, 2 figures. v3: stylistic improvements - formulae simplified, Appendix A integrated into the main text
DOWNLOADS Yarichin Bitch Club, Vol. 5 by Ogeretsu Tanaka
Creators: name: Flanagan
Publisher: name: Zenodo
Year: 2024

description: Yarichin Bitch Club, Vol. 5 by Ogeretsu Tanaka

 

 

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Yarichin Bitch Club, Vol. 5

Ogeretsu Tanaka

Page: 192

Format: pdf, ePub, mobi, fb2

ISBN: 9781974738991

Publisher: SuBLime

 

French books pdf download Yarichin Bitch Club, Vol. 5 (English Edition)

Overview

In an extracurricular experience gone hilariously wrong, innocent Takashi Tono accidentally joins a club of young men who put the “dick” in “valedictorian.” At an all-boys’ boarding school deep in the mountains, hapless transfer student Takashi Tono joins the Photography Club, only to learn too late that the club’s main extracurricular activity is offering its sexual services to the student body! Now that Takashi’s surrounded by bedroom aces, can this virgin survive a day, much less the whole school year, as part of the school’s most lascivious club? In a bid to stave off the sex quota required of the promiscuous Photography Club members, first-year Takashi Tono has protected his virginity by fake-dating fellow club member Yu Kashima. But while Kashima’s affections are real, Tono still has a crush on his sweet-and-sour classmate Yacchan—and so does club upperclassman Tamura! When confessions spill out, hearts will break! But could something even more scandalous be afoot when club president Akemi reveals a long-held secret?
PDF [DOWNLOAD] All That's Left to Say by Emery Lord on Iphone
Creators: name: Hinton
Publisher: name: Zenodo
Year: 2024

description: All That's Left to Say by Emery Lord

 

 

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All That's Left to Say

Emery Lord

Page: 400

Format: pdf, ePub, mobi, fb2

ISBN: 9781681199412

Publisher: Bloomsbury USA

 

Share download books All That's Left to Say PDB by Emery Lord (English literature) 9781681199412

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Figure S10 from Comparative genomic analysis of the ‘psuedofungus’ Hyphochytrium catenoides.
Creators: name: Leonard, Guy
name: Labarre, Aurélie
name: Milner, David S.
name: Monier, Adam
name: Soanes, Darren
name: Wideman, Jeremy G.
name: Maguire, Finlay
name: Stevens, Sam
name: Sain, Divya
name: Grau-Bove, Xavier
name: Arnau Sebe-Pedros
name: Stajich, Jason E.
name: Paszkiewicz, Konrad
name: Brown, Matthew W.
name: Hall, Neil
name: Wickstead, Bill
name: Richards, Thomas A.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 60408 Genomics
subject: FOS: Biological sciences

description: Eukaryotic microbes have three primary mechanisms for obtaining nutrients and energy: phagotrophy, photosynthesis and osmotrophy. Traits associated with the latter two functions arose independently multiple times in the eukaryotes. Fungi successfully coupled osmotrophy with filamentous growth, similar traits are also manifested in the Pseudofungi (oomycetes and hyphochytriomycetes). Both the Fungi and the Pseudofungi encompass a diversity of plant and animal parasites. Genome-sequencing efforts have focused on host-associated microbes (mutualistic symbionts or parasites), providing limited comparisons with free-living relatives. Here we report the first draft genome sequence of a hyphochytriomycete ‘pseudofungus’; Hyphochytrium catenoides. Using phylogenomic approaches, we identify genes of recent viral ancestry, with related viral derived genes also present on the genomes of oomycetes, suggesting a complex history of viral coevolution and integration across the Pseudofungi. H. catenoides has a complex life cycle involving diverse filamentous structures and a flagellated zoospore with a single anterior-tinselate flagellum. We use genome comparisons, drug sensitivity analysis and high-throughput culture arrays to investigate the ancestry of oomycete/pseudofungal characteristics and metabolic traits, demonstrating that many of the genetic features associated with pathogenic traits evolved specifically within the oomycete radiation. Comparative genomics also identified differences in the repertoire of genes associated with filamentous growth between the Fungi and the Pseudofungi, including differences in vesicle trafficking systems, cell-wall synthesis pathways and motor protein repertoire, demonstrating that unique cellular systems underpinned the convergent evolution of filamentous osmotrophic growth in these two eukaryotic groups.
Nck enables directional cell migration through the coordination of polarized membrane protrusion with adhesion dynamics
Creators: name: Sreenivasappa, Harini
name: Rivera, Gonzalo M.
name: Barhoumi, Rola
name: Berginski, Matthew E.
name: Trache, Andreea
name: Gomez, Shawn M.
name: Chaki, Sankar P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Directional migration requires the coordination of cytoskeletal changes essential for cell polarization and adhesion turnover. Extracellular signals that alter tyrosine phosphorylation drive directional migration by inducing reorganization of the actin cytoskeleton. It is recognized that Nck is an important link between tyrosine phosphorylation and actin dynamics; however, the role of Nck in cytoskeletal remodeling during directional migration and the underlying molecular mechanisms remain largely undetermined. In this study, a combination of molecular genetics and quantitative live cell microscopy was used to show that Nck is essential in the establishment of front-back polarity and directional migration of endothelial cells. Time-lapse differential interference contrast and total internal reflection fluorescence microscopy showed that Nck couples the formation of polarized membrane protrusions with their stabilization through the assembly and maturation of cell-substratum adhesions. Measurements by atomic force microscopy showed that Nck also modulates integrin α5β1-fibronectin adhesion force and cell stiffness. Fluorescence resonance energy transfer imaging revealed that Nck depletion results in delocalized and increased activity of Cdc42 and Rac. By contrast, the activity of RhoA and myosin II phosphorylation were reduced by Nck knockdown. Thus, this study identifies Nck as a key coordinator of cytoskeletal changes that enable cell polarization and directional migration, which are crucial processes in development and disease.
(2803) Anne Maria Willis
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Medical decision-making in the diagnosis and treatment initiation of tuberculosis: protocol for an umbrella review with systematic methods
Creators: name: Sedona Sweeney
name: Pitchaya Indravudh
name: Singh, Maninder Pal
name: Bijker, Else
name: Basile, Francesca Wanda
name: Vassall, Anna
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Social and Behavioral Sciences
subject: Public Health
subject: International Public Health
subject: Medicine and Health Sciences
subject: Diseases
subject: Medical Specialties
subject: Diagnosis
subject: Health Services Research
subject: Other Social and Behavioral Sciences
subject: Analytical, Diagnostic and Therapeutic Techniques and Equipment

description: Umbrella review protocol
On finite sets of small tripling or small alternation in arbitrary groups
Creators: name: Conant, Gabriel
Publisher: name: arXiv
Year: 2018
Subjects: subject: Combinatorics (math.CO)
subject: Logic (math.LO)
subject: FOS: Mathematics

description: We prove Bogolyubov-Ruzsa-type results for finite subsets of groups with small tripling, $|A^3|\leq O(|A|)$, or small alternation, $|AA^{\text{-}1} A|\leq O(|A|)$. As applications, we obtain a qualitative analog of Bogolyubov's Lemma for dense sets in arbitrary finite groups, as well as a quantitative arithmetic regularity lemma for sets of bounded VC-dimension in finite groups of bounded exponent. The latter result generalizes the abelian case, due to Alon, Fox, and Zhao, and gives a quantitative version of previous work of the author, Pillay, and Terry.
description: 24 pages, final version
PDF EPUB Download Overreach: The Inside Story of Putin's War Against Ukraine by Owen Matthews Full Book
Creators: name: Hager
Publisher: name: Zenodo
Year: 2024

description: Overreach: The Inside Story of Putin's War Against Ukraine by Owen Matthews

 

 

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Overreach: The Inside Story of Putin's War Against Ukraine

Owen Matthews

Page: 432

Format: pdf, ePub, mobi, fb2

ISBN: 9780008562748

Publisher: HarperCollins UK

 

Download ebook for free for mobile Overreach: The Inside Story of Putin's War Against Ukraine by Owen Matthews

Overreach: The Inside Story of Putin and Russia's War The Inside Story of Putin and Russia's War Against Ukraine Overreach: The Inside Story of Putin's War Against Ukraine Overreach: The Inside Story of Putin's War Against Ukraine Overreach: the Inside Story of Putin's War Against Ukraine
Figure S13 from Comparative genomic analysis of the ‘psuedofungus’ Hyphochytrium catenoides
Creators: name: Leonard, Guy
name: Labarre, Aurélie
name: Milner, David S.
name: Monier, Adam
name: Soanes, Darren
name: Wideman, Jeremy G.
name: Maguire, Finlay
name: Stevens, Sam
name: Sain, Divya
name: Grau-Bove, Xavier
name: Arnau Sebe-Pedros
name: Stajich, Jason E.
name: Paszkiewicz, Konrad
name: Brown, Matthew W.
name: Hall, Neil
name: Wickstead, Bill
name: Richards, Thomas A.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 60408 Genomics
subject: FOS: Biological sciences

description: Eukaryotic microbes have three primary mechanisms for obtaining nutrients and energy: phagotrophy, photosynthesis and osmotrophy. Traits associated with the latter two functions arose independently multiple times in the eukaryotes. Fungi successfully coupled osmotrophy with filamentous growth, similar traits are also manifested in the Pseudofungi (oomycetes and hyphochytriomycetes). Both the Fungi and the Pseudofungi encompass a diversity of plant and animal parasites. Genome-sequencing efforts have focused on host-associated microbes (mutualistic symbionts or parasites), providing limited comparisons with free-living relatives. Here we report the first draft genome sequence of a hyphochytriomycete ‘pseudofungus’; Hyphochytrium catenoides. Using phylogenomic approaches, we identify genes of recent viral ancestry, with related viral derived genes also present on the genomes of oomycetes, suggesting a complex history of viral coevolution and integration across the Pseudofungi. H. catenoides has a complex life cycle involving diverse filamentous structures and a flagellated zoospore with a single anterior-tinselate flagellum. We use genome comparisons, drug sensitivity analysis and high-throughput culture arrays to investigate the ancestry of oomycete/pseudofungal characteristics and metabolic traits, demonstrating that many of the genetic features associated with pathogenic traits evolved specifically within the oomycete radiation. Comparative genomics also identified differences in the repertoire of genes associated with filamentous growth between the Fungi and the Pseudofungi, including differences in vesicle trafficking systems, cell-wall synthesis pathways and motor protein repertoire, demonstrating that unique cellular systems underpinned the convergent evolution of filamentous osmotrophic growth in these two eukaryotic groups.
СУТ БЕЗИ САРАТОНИ КАСАЛЛИГИНИ ТАЖРИБА ҲАЙВОНЛАРИДА ИНДУКЦИЯЛАШ
Creators: name: Халикова, Феруза
name: Бахронов, Журъат
Publisher: name: Zenodo
Year: 2025

description: Тиббиёт ривожланиши йўлида олиб бориладиган тадқиқотларда касалликларни биологик моделлаштириш илмий изланишнинг энг муҳим усулига айланиб бормоқда, бу эса лаборатория ҳайвонларида инсон касалликларининг пайдо бўлиши, ривожланиши ва даволаниш механизмларини энг муносиб тарзда акс эттирадиган экспериментал моделларни яратишни талаб қилади. Сут бези саратонининг молекуляр тузилиши ва унинг иммуногистокимёвий белгиларини ўрганиш натижаларига кўра, сут бези саратонининг молекуляр таснифи таклиф қилинган. Бундай тадқиқотларни ўтказиш лаборатория ҳайвонларининг тузилиши ҳақида батафсил маълумотларисиз тасаввур қилиб бўлмайди. Моделлаштириш тажрибасининг энг муҳим таркибий қисми бўлиб, ҳозирги кунга қадар кам ўрганилган.
(2804) William Willis
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(2805) William Mann
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
TEM4 is a junctional Rho GEF required for cell-cell adhesion, monolayer integrity and barrier function
Creators: name: Ngok, Siu P.
name: Geyer, Rory
name: Der, Channing
name: Feathers, Ryan
name: Kourtidis, Antonis
name: Anastasiadis, Panos Z.
name: Mitin, Natalia
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Signaling events mediated by Rho family GTPases orchestrate cytoskeletal dynamics and cell junction formation. The activation of Rho GTPases is tightly regulated by guanine-nucleotide-exchange factors (GEFs). In this study, we identified a novel Rho-specific GEF called TEM4 (tumor endothelial marker 4) that associates with multiple members of the cadherin–catenin complex and with several cytoskeleton-associated proteins. Depending on confluence, TEM4 localized to either actin stress fibers or areas of cell–cell contact. The junctional localization of TEM4 was independent of actin binding. Depletion of endogenous TEM4 by shRNAs impaired Madin–Darby canine kidney (MDCK) and human umbilical vein endothelial cell (HUVEC) cell junctions, disrupted MDCK acini formation in 3D culture and negatively affected endothelial barrier function. Taken together, our findings implicate TEM4 as a novel and crucial junctional Rho GEF that regulates cell junction integrity and epithelial and endothelial cell function.
Descargar [PDF] {EPUB} COMO PIENSAN LOS RICOS
Creators: name: Gandhi
Publisher: name: Zenodo
Year: 2024

description: COMO PIENSAN LOS RICOS de MORGAN HOUSEL

Descargar eBook gratis ➡ Link

Ficha técnica

COMO PIENSAN LOS RICOS

MORGAN HOUSEL

Número de páginas: 312

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788408246121

Editorial: PLANETA

Año de edición: 2021

 

 

 

 

 

Libros gratis para descargar en color nook. COMO PIENSAN LOS RICOS de MORGAN HOUSEL 9788408246121

 

Overview

En cuestiones de dinero, lo que importa no es lo listo que seas sino cómo te comportas. Tendemos a pensar en la inversión o la gestión de las finanzas personales como una disciplina matemática, en la que los datos y las fórmulas nos dicen exactamente qué hacer. Sin embargo, el rasgo que define a las personas que logran enriquecerse no es su destreza con los números, ni su salario o su talento, sino su historia personal, sus motivaciones y su visión única del mundo. Un genio que pierde el control de sus emociones puede ser un desastre financiero. Y lo mismo vale en caso contrario: gente de a pie sin formación en finanzas puede enriquecerse si cuenta con unos cuantos patrones de comportamiento. Esto, impensable en otras disciplinas como la arquitectura o la medicina, es fundamental en el campo de las finanzas. Este libro, llamado a convertirse en un clásico de las finanzas personales, nos provee del conocimiento esencial para entender la psicología del dinero y nos invita a hacernos una pregunta fundamental que raramente nos hacemos, cuál es nuestra relación con el dinero y qué queremos realmente de él. A partir de 18 claves imperecederas, Morgan Housel nos enseña cómo funciona la psicología del dinero y cuáles son los hábitos y conductas que nos ayudarán no solo a generar riqueza, sino, más importante aún, a conservarla.   «Un libro imprescindible para cualquiera que quiera tomar decisiones más inteligentes y vivir una vida más rica.» Daniel Pink, autor de La sorprendente verdad sobre qué nos motiva «Ideas fascinantes y consejos prácticos. Cualquiera que quiera hacerse rico debería tener una copia de este libro.» James Clear, autor de Hábitos atómicos «Uno de los mejores y más originales libros de finanzas de los últimos años.» Jason Zweig, Wall Street Journal «Housel es de esos escritores capaces de hacer digeribles conceptos financieros de lo más complejos. Este es un libro que se devora de principio a fin y que no solo nos explica por qué tomamos malas decisiones con respecto al dinero, sino que nos ayudará a tomar mejores.» Annie Duke, autora de Thinking in Bets La riqueza no es fruto de nuestra inteligencia, talento o trabajo.  Es fruto de nuestro comportamiento.
Additional file 3 of Anopheline diversity in urban and peri-urban malaria foci: comparison between alternative traps and seasonal effects in a city in the Western Brazilian Amazon
Creators: name: Meireles, Anne Caroline Alves
name: da Silva, Lucas Rosendo
name: Simplício, Marlon Ferreira
name: de Lima, Alzemar Alves
name: Rios, Flávia Geovana Fontineles
name: de Menezes, Carla Augusta
name: Feitoza, Luiz Henrique Maciel
name: Julião, Genimar Rebouças
Publisher: name: figshare
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 3. Non-anopheline mosquitoes and other Dipterans. Table S3. Number of non-anopheline mosquitoes, biting midges, and sand flies caught with Gazetrap, PHLC, and Screen, at urban and peri-urban settings. Table S4. Number of non-anopheline mosquitoes, biting midges, and sand flies caught during seasonal periods, at urban and peri-urban settings.
Pre-therapeutic sarcopenia among cancer patients: An up-to-date meta-analysis of prevalence and predictive value during cancer treatment
Creators: name: , PAMOUKDJIAN
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Medical Sciences
subject: Clinical Epidemiology
subject: Public Health
subject: Medical Nutrition
subject: Medicine and Health Sciences

description: An up to date systematic review with meta-analysis on the prevalence of pre-therapeutic sarcopenia (PS) among cancer patients and its predictive value for overall survival, progression free survival, post-operative complications, treatment-related toxicities, and hospital-acquired infections.
Some applications of the parameterized Picard-Vessiot theory
Creators: name: Mitschi, Claude
Publisher: name: arXiv
Year: 2015
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics
subject: Primary 34M56, 12H05, 34M55

description: This expository paper presents some applications of the parameterized Picard-Vessiot theory for ordinary differential equations, mainly related to monodromy.
description: to appear; Izvestyia RAN, Seriya Matematicheskaya, 2015
Algebraic tangent cones of reflexive sheaves
Creators: name: Chen, Xuemiao
name: Sun, Song
Publisher: name: arXiv
Year: 2018
Subjects: subject: Differential Geometry (math.DG)
subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics

description: We study the notion of algebraic tangent cones at singularities of reflexive sheaves. These correspond to extensions of reflexive sheaves across a negative divisor. We show the existence of optimal extensions in a constructive manner, and we prove the uniqueness in a suitable sense. The results here are an algebro-geometric counterpart of our previous study on singularities of Hermitian-Yang-Mills connections.
9 MESES DESDE DENTRO EDUARD GRATACOS SOLSONA ePub gratis
Creators: name: Smith
Publisher: name: Zenodo
Year: 2024

description: 9 MESES DESDE DENTRO de EDUARD GRATACOS SOLSONA

Descargar eBook gratis ➡ Link

Ficha técnica

9 MESES DESDE DENTRO

EDUARD GRATACOS SOLSONA

Número de páginas: 384

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788408246565

Editorial: PLANETA

Año de edición: 2021

 

 

 

 

 

Descargas gratuitas de audiolibros en línea. 9 MESES DESDE DENTRO 9788408246565 de EDUARD GRATACOS SOLSONA

 

Overview

Una guía diferente del embarazo para descubrir lo que siente tu hijo desde las primeras semanas de vida. 9 meses desde dentro es un diario del embarazo que te ayudará a conocer mejor cada una de les cuarenta semanas de gestación y te emocionará con el sorprendente relato de la evolución de la primera célula en su maravilloso trayecto de feto a bebé. A través de las explicaciones y consejos del doctor Gratacós, experto internacional en desarrollo fetal, y de la propia voz del bebé, que ofrece su particular visión de todo lo que le ocurre desde su concepción hasta el parto, 9 meses desde dentro te acompañará en la aventura de la gestación de una manera diferente y te atrapará desde las primeras páginas. ¡Nunca te lo habían explicado así!
ZO-1 recruitment to  -catenin - a novel mechanism for coupling the assembly of tight junctions to adherens junctions
Creators: name: Peng, Xiao
name: DeMali, Kris A.
name: Fanning, Alan S.
name: Maiers, Jessica L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The formation of a barrier between epithelial cells is a fundamental determinant of cellular homeostasis, protecting underlying cells against pathogens, dehydration and damage. Assembly of the tight junction barrier is dependent upon neighboring epithelial cells binding to one another and forming adherens junctions, but the mechanism for how these processes are linked is poorly understood. Using a knockdown and substitution system, we studied whether ZO-1 binding to α-catenin is required for coupling tight junction assembly to the formation of adherens junctions. We found that preventing ZO-1 binding to α-catenin did not appear to affect adherens junctions. Rather the assembly and maintenance of the epithelial barrier were disrupted. This disruption was accompanied by alterations in the mobility of ZO-1 and the organization of the actin cytoskeleton. Thus, our study identifies α-catenin binding to ZO-1 as a new mechanism for coupling the assembly of the epithelial barrier to cell-to-cell adhesion.
An Intervention Approach to Reducing Threat Appraisal and Avoidance Associated with Intergroup Interactions
Creators: name: Gonsalkorale, Karen
name: Aydogan, Adem Fatih
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Cognitive Psychology
subject: Social Psychology
subject: Clinical Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: Open access data repository for the article for the article "An Intervention Approach to Reducing Threat Appraisal and Avoidance Associated with Intergroup Interactions"
Additional file 4 of Anopheline diversity in urban and peri-urban malaria foci: comparison between alternative traps and seasonal effects in a city in the Western Brazilian Amazon
Creators: name: Meireles, Anne Caroline Alves
name: da Silva, Lucas Rosendo
name: Simplício, Marlon Ferreira
name: de Lima, Alzemar Alves
name: Rios, Flávia Geovana Fontineles
name: de Menezes, Carla Augusta
name: Feitoza, Luiz Henrique Maciel
name: Julião, Genimar Rebouças
Publisher: name: figshare
Year: 2022
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 4. Supplementary results for the number of individuals/species of Anopheles. Model Output – Best-fitted models. PERMANOVA / PERMDISP estimates and NMDS plots. Table S5. Anopheles species and individuals (N) captured at urban and peri-urban settings of Porto Velho, state of Rondônia, Brazilian Amazon. Table S6. Anopheles species and individuals (N) captured through Gazetrap, PHLC, and Barrier Screen in Porto Velho, state of Rondônia, Brazilian Amazon. Table S7. Anopheles species and individuals (N) captured in the Dry, Rainy, and Transitional seasons, at Porto Velho, state of Rondônia, Brazilian Amazon. Table S8. Summary of estimates from the best approximation models for anopheline abundance and richness. Table S9. PERMANOVA and PERMDISP analyses for Anopheles assemblage structure between seasons and sampling techniques. Fig. S2. Non-metric multidimensional scaling (NMDS) plots for graphical visualization of the PERMANOVA and PERMDISP analyses of Anopheles assemblage structure.
Biotin ligase tagging identifies proteins proximal to E-cadherin, including lipoma preferred partner, a regulator of epithelial cell–cell and cell–substrate adhesion
Creators: name: Tietgens, Amber Jean
name: Van Itallie, Christina M.
name: Fredriksson, Karin
name: Aponte, Angel
name: Fanning, Alan S.
name: Anderson, James M.
name: Gucek, Marjan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Known proteins associated with the cell-adhesion protein E-cadherin include catenins and proteins involved in signaling, trafficking and actin organization. However, the list of identified adherens junction proteins is likely to be incomplete, limiting investigation into this essential cell structure. To expand the inventory of potentially relevant proteins, we expressed E-cadherin fused to biotin ligase in MDCK epithelial cells, and identified by mass spectrometry neighboring proteins that were biotinylated. The most abundant of the 303 proteins identified were catenins and nearly 40 others that had been previously reported to influence cadherin function. Many others could be rationalized as novel candidates for regulating the adherens junction, cytoskeleton, trafficking or signaling. We further characterized lipoma preferred partner (LPP), which is present at both cell contacts and focal adhesions. Knockdown of LPP demonstrated its requirement for E-cadherin-dependent adhesion and suggested that it plays a role in coordination of the cell–cell and cell–substrate cytoskeletal interactions. The analysis of LPP function demonstrates proof of principle that the proteomic analysis of E-cadherin proximal proteins expands the inventory of components and tools for understanding the function of E-cadherin.
Abstract or concrete? A scoping review into how construal level theory can make alcohol health warning labels more effective
Creators: name: Lang, Bodo
name: Marks, Cameron
name: Walker, Natalie
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Social and Behavioral Sciences
subject: Medicine and Health Sciences

description: The aim of this scoping review is to summarise the literature on the topic of construal level theory applied to alcohol harm reduction, particularly relating to the design of alcohol health warning labels.
Multiple endothelial cells constitute the tip of developing blood vessels and polarize to promote lumen formation
Creators: name: Wright, Catherine E.
name: Leitges, Michael
name: Pelton, John C.
name: Bautch, Victoria L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Blood vessel polarization in the apical-basal axis is important for directed secretion of proteins and lumen formation; yet, when and how polarization occurs in the context of angiogenic sprouting is not well understood. Here, we describe a novel topology for endothelial cells at the tip of angiogenic sprouts in several mammalian vascular beds. Two cells that extend filopodia and have significant overlap in space and time were present at vessel tips, both in vitro and in vivo. The cell overlap is more extensive than predicted for tip cell switching, and it sets up a longitudinal cell-cell border that is a site of apical polarization and lumen formation, presumably via a cord-hollowing mechanism. The extent of cell overlap at the tip is reduced in mice lacking aPKCζ, and this is accompanied by reduced distal extension of both the apical border and patent lumens. Thus, at least two polarized cells occupy the distal tip of blood vessel sprouts, and topology, polarization and lumenization along the longitudinal border of these cells are influenced by aPKCζ.
Nanoclustering as a dominant feature of plasma membrane organization
Creators: name: Jacobson, Ken
name: Thompson, Nancy
name: Torreno-Pina, Juan A.
name: Garcia-Parajo, Maria F.
name: Cambi, Alessandra
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Early studies have revealed that some mammalian plasma membrane proteins exist in small nanoclusters. The advent of super-resolution microscopy has corroborated and extended this picture, and led to the suggestion that many, if not most, membrane proteins are clustered at the plasma membrane at nanoscale lengths. In this Commentary, we present selected examples of glycosylphosphatidyl-anchored proteins, Ras family members and several immune receptors that provide evidence for nanoclustering. We advocate the view that nanoclustering is an important part of the hierarchical organization of proteins in the plasma membrane. According to this emerging picture, nanoclusters can be organized on the mesoscale to form microdomains that are capable of supporting cell adhesion, pathogen binding and immune cell-cell recognition amongst other functions. Yet, a number of outstanding issues concerning nanoclusters remain open, including the details of their molecular composition, biogenesis, size, stability, function and regulation. Notions about these details are put forth and suggestions are made about nanocluster function and why this general feature of protein nanoclustering appears to be so prevalent.