cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: The role of contrast enhancement kinetic curves in the differential diagnosis of primary liver tumors with using Gd-EOB-DTPA
Creators: name: Medvedeva, Bela
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Liver
subject: Abdomen
subject: MR
subject: Contrast agent-intravenous
subject: Comparative studies
subject: Cancer
subject: Hyperplasia / Hypertrophy
subject: Haemangioma

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Gd-EOB-DTPA is a paramagnetic contrast agent, which is useful to evaluate liver pathologies. It behaves similarly to non-specific gadolinium chelates during the dynamic phases, and adds substantial information during the hepatobiliary...
Role Identification of Social Networkers
Creators: name: Zygmunt, Anna
Publisher: name: arXiv
Year: 2015
Subjects: subject: Social and Information Networks (cs.SI)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: A social network consists of a set of actors and a set of relationships between them which describe certain patterns of communication. Most current networks are huge and difficult to analyze and visualize. One of the methods frequently used is to extract the most important features, namely to create a certain abstraction, that is the transformation of a large network to a much smaller one, so the latter is a useful summary of the original one, still keeping the most important characteristics. In the case of a social network it can be achieved in two ways. One is to find groups of actors and present only them and relationships between them. The other is to find actors who play similar roles and to construct a smaller network in which the connection between the actors would be replaced with connections between the roles. Classifying actors by the roles they are playing in the network can help to understand 'who is who' in a social network. This classification can be very useful, because it gives us a comprehensive view of the network and helps to understand how the network is organized, and to predict how it could behave in the case of certain events (internal or external).
Addendum to [Grand Theft Empathy: The effects of violent video games on empathy]
Creators: name: Lengersdorff, Lukas
name: Wagner, Isabella
name: Lamm, Claus
name: Olsson, Andreas
name: Petrovic, Predrag
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: See "Summary" for changes to the registration.
title: Solitary fibrous tumor of the pleura and CT findings: Cases analysis
Creators: name: Parrilla Muñoz, Cristina
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Neoplasia
subject: Computer Applications-General
subject: CT
subject: Lung

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Solitary fibrous tumour of the pleura (SFTP) is a mesenchymal tumour that tends to involve the pleura, although it has also been described in other thoracic areas and in extrathoracic sites. It is usually a benign tumour, although a small percentage...
Test particles in a magnetized conformastatic spacetime
Creators: name: Gutiérrez-Piñeres, Antonio C.
name: Capistrano, Abraão J. S.
name: Quevedo, Hernando
Publisher: name: arXiv
Year: 2016
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: A class of exact conformastatic solutions of the Einstein-Maxwell field equations is presented in which the gravitational and electromagnetic potentials are completely determined by a harmonic function. We derive the equations of motion for neutral and charged particles in a spacetime background characterized by this class of solutions. As an example, we focus on the analysis of a particular harmonic function, which generates a singularity-free and asymptotically flat spacetime that describes the gravitational field of a punctual mass endowed with a magnetic field. In this particular case, we investigate the main physical properties of equatorial circular orbits. We show that due to the electromagnetic interaction, it is possible to have charged test particles which stay at rest with respect to a static observer located at infinity. Additionally, we obtain an analytic expression for the perihelion advance of test particles and the corresponding explicit value in the case of a punctual magnetic mass. We show that the analytical expressions obtained from our analysis are sufficient for being confronted with observations in order to establish whether such objects can exist in nature.
description: Updated version to match with the published version in Physical Review D
Room-temperature spin-orbit torque in NiMnSb
Creators: name: Ciccarelli, C.
name: Anderson, L.
name: Tshitoyan, V.
name: Ferguson, A. J.
name: Gerhard, F.
name: Gould, C.
name: Molenkamp, L. W.
name: Gayles, J.
name: Zelezny, J.
name: Smejkal, L.
name: Yuan, Z.
name: Sinova, J.
name: Freimuth, F.
name: Jungwirth, T.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Materials that crystalize in diamond-related lattices, with Si and GaAs as their prime examples, are at the foundation of modern electronics. Simultaneoulsy, the two atomic sites in the unit cell of these crystals form inversion partners which gives rise to relativistic non-equilibrium spin phenomena highly relevant for magnetic memories and other spintronic devices. When the inversion-partner sites are occupied by the same atomic species, electrical current can generate local spin polarization with the same magnitude and opposite sign on the two inversion-partner sites. In CuMnAs, which shares this specific crystal symmetry of the Si lattice, the effect led to the demonstration of electrical switching in an antiferromagnetic memory at room temperature. When the inversion-partner sites are occupied by different atoms, a non-zero global spin-polarization is generated by the applied current which can switch a ferromagnet, as reported at low temperatures in the diluted magnetic semiconductor (Ga,Mn)As. Here we demonstrate the effect of the global current-induced spin polarization in a counterpart crystal-symmetry material NiMnSb which is a member of the broad family of magnetic Heusler compounds. It is an ordered high-temperature ferromagnetic metal whose other favorable characteristics include high spin-polarization and low damping of magnetization dynamics. Our experiments are performed on strained single-crystal epilayers of NiMnSb grown on InGaAs. By performing all-electrical ferromagnetic resonance measurements in microbars patterned along different crystal axes we detect room-temperature spin-orbit torques generated by effective fields of the Dresselhaus symmetry. The measured magnitude and symmetry of the current-induced torques are consistent with our relativistic density-functional theory calculations.
Plasmodium falciparum parasitaemia in the first half of pregnancy, uterine and umbilical artery blood flow, and foetal growth: a longitudinal Doppler ultrasound study
Creators: name: Meshnick, Steven R.
name: Herring, Amy
name: Griffin, Jennifer B
name: Thorp, John M
Publisher: name: BioMed Central Ltd
Year: 2012

description: Abstract Background During early pregnancy, the placenta develops to meet the metabolic demands of the foetus. The objective of this analysis was to examine the effect of malaria parasitaemia prior to 20 weeks’ gestation on subsequent changes in uterine and umbilical artery blood flow and intrauterine growth restriction. Methods Data were analysed from 548 antenatal visits after 20 weeks’ gestation of 128 women, which included foetal biometric measures and interrogation of uterine and umbilical artery blood flow. Linear mixed effect models estimated the effect of early pregnancy malaria parasitaemia on uterine and umbilical artery resistance indices. Log-binomial models with generalized estimating equations estimated the effect of early pregnancy malaria parasitaemia on the risk of intrauterine growth restriction. Results There were differential effects of early pregnancy malaria parasitaemia on uterine artery resistance by nutritional status, with decreased uterine artery resistance among nourished women with early pregnancy malaria and increased uterine artery resistance among undernourished women with early pregnancy malaria. Among primigravidae, early pregnancy malaria parasitaemia decreased umbilical artery resistance in the late third trimester, likely reflecting adaptive villous angiogenesis. In fully adjusted models, primigravidae with early pregnancy malaria parasitaemia had 3.6 times the risk of subsequent intrauterine growth restriction (95% CI: 2.1, 6.2) compared to the referent group of multigravidae with no early pregnancy malaria parasitaemia. Conclusions Early pregnancy malaria parasitaemia affects uterine and umbilical artery blood flow, possibly due to alterations in placentation and angiogenesis, respectively. Among primigravidae, early pregnancy malaria parasitaemia increases the risk of intrauterine growth restriction. The findings support the initiation of malaria parasitaemia prevention and control efforts earlier in pregnancy.
Chemotherapy-induced Sinusoidal Injury (CSI) score: a novel histologic assessment of chemotherapy-related hepatic sinusoidal injury in patients with colorectal liver metastasis
Creators: name: Sasatomi, Eizaburo
Publisher: name: BioMed Central
Year: 2017

description: Abstract Background Preoperative neoadjuvant therapy for colorectal liver metastases (CRLM) is increasing in use and can lead to chemotherapy-induced damage to sinusoidal integrity, namely sinusoidal obstruction syndrome (SOS). SOS has been associated with an increased need for intraoperative blood transfusions, increased length of hospitalization post-surgery, decreased tumor response, and a shorter overall survival after resection due to liver insufficiency. It is critical for clinicians and pathologists to be aware of this type of liver injury, and for pathologists to include the status of the background, non-neoplastic liver parenchyma in their pathology reports. In this study, expression of CD34 by sinusoidal endothelial cells (SECs), increased expression of smooth muscle actin (SMA) by hepatic stellate cells (HSCs), and aberrant expression of glutamine synthetase (GS) by noncentrizonal hepatocytes were semiquantitatively evaluated in liver resection or biopsy specimens from patients with CRLM to determine their diagnostic value for assessing chemotherapy-induced sinusoidal injury (CSI). Methods The expression of each marker was compared among 22 patients with CRLM with histologically evident SOS (SOS+) and 8 patients with CRLM who had not undergone chemotherapy. Each case was given a histologic grade using the sinusoidal obstruction syndrome index score (SOS-I) to assess the likelihood of SOS. Cases were also given an immunohistochemical grade using the total CSI score calculated as the sum of CD34, SMA, and GS scores. Results Abnormal staining patterns for CD34 and SMA were significantly more frequent and extensive in SOS+ cases than in the controls (81.8% vs. 25%, P < 0.01; 72.7% vs. 25%, P = 0.03). Aberrant GS expression in midzonal and periportal hepatocytes was only observed in SOS+ cases (31.8% vs. 0%), but this difference did not reach statistical significance. The CSI score was significantly higher in the SOS+ cases when compared to controls (P < 0.01), and was associated with a higher SOS histologic grade (P = 0.02). Conclusions The CSI score, calculated using an immunohistochemical panel consisting of CD34, SMA, and GS, may serve as an objective marker of chemotherapy-induced sinusoidal injury and could help diagnose this peculiar form of liver injury.
High energy cosmic ray self-confinement close to extragalactic sources
Creators: name: Blasi, P.
name: Amato, E.
name: D'Angelo, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The ultra-high energy cosmic rays observed at the Earth are most likely accelerated in extra-galactic sources. For the typical luminosities invoked for such sources, the electric current associated to the flux of cosmic rays that leave them is large. The associated plasma instabilities create magnetic fluctuations that can efficiently scatter particles. We argue that this phenomenon forces cosmic rays to be self-confined in the source proximity for energies $E
description: To Appear in Physical Review Letters
MPEC 2023-F140 : 2023 FA4
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 FA4

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
title: Feasibility of CT angiography acquired with low tube voltage and low iodine retrospective evaluation of radiation dose, image quality and iodine load
Creators: name: Bherwani, Anand
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Arteries / Aorta
subject: Cardiovascular system
subject: Contrast agents
subject: CT-Angiography
subject: Image manipulation / Reconstruction
subject: CT-High Resolution
subject: Comparative studies
subject: Contrast agent-intravenous
subject: Statistics
subject: Dosimetric comparison
subject: Quality assurance
subject: Patterns of Care

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: With increasing usage of computed tomography (CT) procedures in recent years, there is a growing awareness andconcern among society, government, referring physicians and patients towards the potential risk of cancer related to excessive radiation...
title: Stack effect in buildings
Creators: name: Wilson, A. G.
name: Tamura, G. T.
Publisher: name: National Research Council of Canada. Division of Building Research
Year: 1968
Subjects: subject: Air and vapour barriers
valueUri: urn:ircsubjects:IRC0310
subject: Pare-vapeur et pare-air
valueUri: urn:ircsubjects:IRC0310
subject: Air flow/Wind pressure
valueUri: urn:ircsubjects:IRC0344
subject: Surcharges dues au vent/écoulement d'air
valueUri: urn:ircsubjects:IRC0344
subject: air barriers
subject: pare-air
subject: stack effect
subject: convection naturelle
subject: high rise buildings
subject: construction élevée
subject: air infiltration
subject: infiltration d'air
subject: air exfiltration
subject: exfiltration d'air

description: Stack effect in a building depends on the difference in the temperatures of inside and outside air and the height of a building. The influence of stack effect is significant, particularly in tall buildings, during the winter seasons. This Digest describes the distribution of the total pressure difference caused by stack action across a building enclosure and interior separations and the many implications of the resulting air flow patterns.
Interventions to promote access to primary health care for people with severe mental illness: a scoping review protocol
Creators: name: Jacobi, Frank
name: Jiménez, Naomi
name: Strunz, Michael
name: Gregorius, Lisa
name: Pollmanns, Johannes
name: Viehmann, Kerstin
name: Hewer, Walter
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: Coordinated Care
subject: Integrated Care
subject: Physical Health
subject: Severe Mental Illness
subject: SMI

description: Excess mortality in people with severe mental illness (SMI) is a well-known and extensively described issue. Patient-centered interventions to promote use of and access to existing primary health care settings appear to be another low-threshold approach to the described problem. To our knowledge, this sub-concept of integrated care has not been investigated systematically and is therefore subject of the planned scoping review.
Conducting interfaces between amorphous oxide layers and SrTiO3(110) and SrTiO3(111)
Creators: name: Scigaj, Mateusz
name: Gazquez, Jaume
name: Varela, Maria
name: Fontcuberta, Josep
name: Herranz, Gervasi
name: Sanchez, Florencio
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Interfaces between (110) and (111)SrTiO3 (STO) single crystalline substrates and amorphous oxide layers, LaAlO3 (a-LAO), Y:ZrO2 (a-YSZ), and SrTiO3 (a-STO) become conducting above a critical thickness tc. Here we show that tc for a-LAO is not depending on the substrate orientation, i.e. tc (a-LAO/(110)STO) ~ tc(a-LAO/(111)STO) interfaces, whereas it strongly depends on the composition of the amorphous oxide: tc(a-LAO/(110)STO) < tc(a-YSZ/(110)STO) < tc(a-STO/(110)STO). It is concluded that the formation of oxygen vacancies in amorphous-type interfaces is mainly determined by the oxygen affinity of the deposited metal ions, rather than orientational-dependent enthalpy vacancy formation and diffusion. Scanning transmission microscopy characterization of amorphous and crystalline LAO/STO(110) interfaces shows much higher amount of oxygen vacancies in the former, providing experimental evidence of the distinct mechanism of conduction in these interfaces.
An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration
Creators: name: Elston, Timothy
name: Hahn, Klaus
name: Allen, Richard
Publisher: name: BioMed Central
Year: 2018

description: Abstract Background Cell migration is essential for development and tissue repair, but it also contributes to disease. Rho GTPases regulate cell migration, but a comprehensive analysis of how each Rho signalling component affects migration has not been carried out. Results Through an RNA interference screen, and using a prostate cancer cell line, we find that approximately 25% of Rho network components alter migration. Some genes enhance migration while others decrease basal and/or hepatocyte growth factor-stimulated migration. Surprisingly, we identify RhoH as a screen hit. RhoH expression is normally restricted to haematopoietic cells, but we find it is expressed in multiple epithelial cancer cell lines. High RhoH expression in samples from prostate cancer patients correlates with earlier relapse. RhoH depletion reduces cell speed and persistence and decreases migratory polarity. Rac1 activity normally localizes to the front of migrating cells at areas of dynamic membrane movement, but in RhoH-depleted cells active Rac1 is localised around the whole cell periphery and associated with membrane regions that are not extending or retracting. RhoH interacts with Rac1 and with several p21-activated kinases (PAKs), which are Rac effectors. Similar to RhoH depletion, PAK2 depletion increases cell spread area and reduces cell migration. In addition, RhoH depletion reduces lamellipodium extension induced by PAK2 overexpression. Conclusions We describe a novel role for RhoH in prostate cancer cell migration. We propose that RhoH promotes cell migration by coupling Rac1 activity and PAK2 to membrane protrusion. Our results also suggest that RhoH expression levels correlate with prostate cancer progression.
title: Rare localizations of echinococcosis: our personal experience
Creators: name: Mallat, Najoua
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Head and neck
subject: Mediastinum
subject: Abdomen
subject: Ultrasound
subject: CT
subject: MR
subject: Diagnostic procedure
subject: Cysts
subject: Parasites
subject: Infection

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Echinococcosis (or hydatid disease) is the most wide spread serious human parasitic infection in the world caused by a cestode: Echinococcus granulosus. It is endemic in areas with tropical or subtropical climates particularly in Mediterranean...
Towards Precision Supermassive Black Hole Masses using Megamaser Disks
Creators: name: Bosch, Remco C. E. van den
name: Greene, Jenny E.
name: Braatz, James A.
name: Constantin, Anca
name: Kuo, Cheng-Yu
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Megamaser disks provide the most precise and accurate extragalactic supermassive black hole masses. Here we describe a search for megamasers in nearby galaxies using the Green Bank Telescope (GBT). We focus on galaxies where we believe that we can resolve the gravitational sphere of influence of the black hole and derive a stellar or gas dynamical measurement with optical or NIR observations. Since there are only a handful of super massive black holes (SMBH) that have direct black hole mass measurements from more than one method, even a single galaxy with a megamaser disk and a stellar dynamical black hole mass would provide necessary checks on the stellar dynamical methods. We targeted 87 objects from the Hobby-Eberly Telescope Massive Galaxy Survey, and detected no new maser disks. Most of the targeted objects are elliptical galaxies with typical stellar velocity dispersions of 250 km/s and distances within 130 Mpc. We discuss the implications of our non-detections, whether they imply a threshold X-ray luminosity required for masing, or possibly reflect the difficulty of maintaining a masing disk around much more massive (>10^8 Msun) black holes at low Eddington ratio. Given the power of maser disks at probing black hole accretion and demographics, we suggest that future maser searches should endeavour to remove remaining sample biases, in order to sort out the importance of these covariant effects.
description: 9 pages, 5 figures, Apj, updated to match the accepted version
Lopsidedness as a tracer of early galactic assembly history
Creators: name: Dolfi, Arianna
name: Gomez, A. Facundo
name: Monachesi, Antonela
name: Varela-Lavin, Silvio
name: Tissera, B. Patricia
name: Sifoon, Cristobal
name: Galaz, Gaspar
Publisher: name: Zenodo
Year: 2023
Subjects: galaxies: formation -- galaxies: evolution -- galaxies: structure -- galaxies: star formation -- galaxies: interactions

description: Large-scale asymmetries (i.e. lopsidedness) are a common feature in the stellar density distribution of nearby disk galaxies both in low- and high-density environments. In this work, we characterize the present-day lopsidedness in a sample of 1435 disk-like galaxies selected from the TNG50 simulation. We find that the percentage of lopsided galaxies (10%-30%) is in good agreement with observations if we use similar radial ranges to the observations. However, the percentage (58\%) significantly increases if we extend our measurement to larger radii. We find a mild or lack of correlation between lopsidedness amplitude and environment at z=0 and a strong correlation between lopsidedness and galaxy morphology regardless of the environment. Present-day galaxies with more extended disks, flatter inner galactic regions and lower central stellar mass density (i.e. late-type disk galaxies) are typically more lopsided than galaxies with smaller disks, rounder inner galactic regions and higher central stellar mass density (i.e. early-type disk galaxies). Interestingly, we find that lopsided galaxies have, on average, a very distinct star formation history within the last 10 Gyr, with respect to their symmetric counterparts. Symmetric galaxies have typically assembled at early times (\(\sim\)8-6 Gyr ago) with relatively short and intense bursts of central star formation, while lopsided galaxies have assembled on longer timescales and with milder initial bursts of star formation, continuing building up their mass until z=0. Overall, these results indicate that lopsidedness in present-day disk galaxies is connected to the specific evolutionary histories of the galaxies that shaped their distinct internal properties.
title: What can (and will) go wrong in Breast Surgery?
Creators: name: Pereira, Pedro
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Breast
subject: Mammography
subject: MR
subject: Ultrasound
subject: Complications
subject: Education
subject: Surgery
subject: Acute
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To review and illustrate the main imaging findings in non-specific and specific complications of breast-related procedures. To discuss and highlight the role of Radiology in the differential diagnosis of Breast surgery...
title: Working on the roads: improving the infrastructure for research into geo-societal challenges
Creators: name:  Elger , Kirsten
name:  Curdt , Constanze
name:  Pijnenburg , Ronald
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: In response to the growing geo-societal challenges of our densely populated planet, current research frequently requires convergence of multiple research disciplines, and optimized use of openly available data, research facilities and funds. Especially the Earth and environmental sciences play a significant role in addressing these challenges, but require the integration of scientific data, software and tools from multiple, globally distributed resources to unlock their full potential to contribute. In addition, the number of Earth and environmental research data repositories and data portals has increased markedly, and so has their range of maturities and capabilities to integrate into the ecosystem of modern scientific communication. Efforts such as the FAIR Data Principles, the CoreTrustSeal Certification for the trustworthiness of research data repositories, and the Enabling FAIR Data Commitment Statement have raised our expectations towards the capabilities of research data repositories and infrastructures. Now we need to ensure that these expectations are met at all levels, from individual researchers, to data repositories, to research infrastructures. What are the challenges and appropriate strategies? This session invites contributions from different fields of expertise, including research infrastructure or data repository managers, data scientists, interdisciplinary researchers and policy makers. Our aim is to discuss perspectives, experiences, current or future challenges and potential solutions related to creating an effective infrastructure for the environmental and earth sciences.
title: Urgent Endovascular Treatment for Acute Hemohrrage
Creators: name: Cervera Araez, Alicia
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Haemorrhage
subject: Embolisation
subject: Fluoroscopy
subject: CT-Angiography
subject: Vascular
subject: Interventional vascular
subject: Emergency

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: We present the urgent embolisations performed in our Interventional Radiology department from January 2008 to October 2013. Analysis of the indications, the used embolic materials, results, main intra-procedural complications, short-term...
Association of cardiac and vascular changes with ambient PM2.5 in diabetic individuals
Creators: name: Peters, Annette
name: Schmitt, Mike T
name: Buse, John
name: Schneider, Alexandra
name: Graff, Don W
name: Neas, Lucas M
name: Cascio, Wayne E
name: Devlin, Robert B
name: Herbst, Margaret C
Publisher: name: BioMed Central Ltd
Year: 2010

description: Abstract: Background and Objective: Exposure to fine airborne particles (PM2.5) has been shown to be responsible for cardiovascular and hematological effects, especially in older people with cardiovascular disease. Some epidemiological studies suggest that individuals with diabetes may be a particularly susceptible population. This study examined effects of short-term exposures to ambient PM2.5 on markers of systemic inflammation, coagulation, autonomic control of heart rate, and repolarization in 22 adults (mean age: 61 years) with type 2 diabetes. Methods: Each individual was studied for four consecutive days with daily assessments of plasma levels of blood markers. Cardiac rhythm and electrocardiographic parameters were examined at rest and with 24-hour ambulatory ECG monitors. PM2.5 and meteorological data were measured daily on the rooftop of the patient exam site. Data were analyzed with models adjusting for season, weekday, meteorology, and a random intercept. To identify susceptible subgroups, effect modification was analyzed by clinical characteristics associated with insulin resistance as well as with oxidative stress and by medication intake. Results: Interleukin (IL)-6 and tumor necrosis factor alpha showed a significant increase with a lag of two days (percent change of mean level: 20.2% with 95%-confidence interval [6.4; 34.1] and 13.1% [1.9; 24.4], respectively) in association with an increase of 10 μg/m3 in PM2.5. Obese participants as well as individuals with elevated glycosylated hemoglobin, lower adiponectin, higher ferritin or with glutathione S-transferase M1 null genotype showed higher IL-6 effects. Changes in repolarization were found immediately as well as up to four days after exposure in individuals without treatment with a beta-adrenergic receptor blocker. Conclusions: Exposure to elevated levels of PM2.5 alters ventricular repolarization and thus may increase myocardial vulnerability to arrhythmias. Exposure to PM2.5 also increases systemic inflammation. Characteristics associated with insulin resistance or with oxidative stress were shown to enhance the association.
A Simple Multipath OpenFlow Controller using topology-based algorithm for Multipath TCP
Creators: name: Nakasan, Chawanat
name: Ichikawa, Kohei
name: Iida, Hajimu
name: Uthayopas, Putchong
Publisher: name: arXiv
Year: 2015
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences
subject: C.2.1; C.2.2

description: Multipath TCP, or MPTCP, is a widely-researched mechanism that allows a single application-level connection to be split to more than one TCP stream, and consequently more than one network interface, as opposed to the traditional TCP/IP model. Being a transport layer protocol, MPTCP can easily interact between the application using it and the network supporting it. However, MPTCP does not have control of its own route. Default IP routing behavior generally takes all traffic through the shortest or best-metric path. However, this behavior may actually cause paths to collide with each other, creating contention for bandwidth in a number of edges. This can result in a bottleneck which limits the throughput of the network. Therefore, a multipath routing mechanism is necessary to ensure smooth operation of MPTCP. We created smoc, a Simple Multipath OpenFlow Controller, that uses only topology information of the network to avoid collision where possible. Evaluation of smoc in a virtual local-area and a physical wide-area SDNs showed favorable results as smoc provided better performance than simple or spanning-tree routing mechanisms.
description: 8 pages, submitted for PRAGMA-ICDS 2015
Diamond Magnetometry of Meissner Currents in a Superconducting Film
Creators: name: Alfasi, Nir
name: Masis, Sergei
name: Shtempeluk, Oleg
name: Kochetok, Valleri
name: Buks, Eyal
Publisher: name: arXiv
Year: 2016
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study magnetic field penetration into a thin film made of a superconducting niobium. Imaging of magnetic field is performed by optically detecting magnetic resonances of negatively charged nitrogen-vacancy defects inside a single crystal diamond, which is attached to the niobium film under study. The experimental results are compared with theoretical predictions based on the critical state model, and good agreement is obtained.
description: 5 pages, 3 figures
Uniform electron gases: III. Low-density gases on three-dimensional spheres
Creators: name: Agboola, Davids
name: Knol, Anneke L.
name: Gill, Peter M. W.
name: Loos, Pierre-François
Publisher: name: arXiv
Year: 2015
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Other Condensed Matter (cond-mat.other)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: By combining variational Monte Carlo (VMC) and complete-basis-set limit Hartree-Fock (HF) calculations, we have obtained near-exact correlation energies for low-density same-spin electrons on a three-dimensional sphere (3-sphere), i.e.~the surface of a four-dimensional ball. In the VMC calculations, we compare the efficacies of two types of one-electron basis functions for these strongly correlated systems, and analyze the energy convergence with respect to the quality of the Jastrow factor. The HF calculations employ spherical Gaussian functions (SGFs) which are the curved-space analogs of cartesian Gaussian functions. At low densities, the electrons become relatively localized into Wigner crystals, and the natural SGF centers are found by solving the Thomson problem (i.e. the minimum-energy arrangement of $n$ point charges) on the 3-sphere for various values of $n$. We have found 11 special values of $n$ whose Thomson sites are equivalent. Three of these are the vertices of four-dimensional Platonic solids --- the hyper-tetrahedron ($n=5$), the hyper-octahedron ($n=8$) and the 24-cell ($n=24$) --- and a fourth is a highly symmetric structure ($n=13$) which has not previously been reported. By calculating the harmonic frequencies of the electrons around their equilibrium positions, we also find the first-order vibrational corrections to the Thomson energy.
description: 6 pages, 2 figures, accepted for publication in the Journal of Chemical Physics
title: Neuroblastoma: Clinical and radiological features in common and atypical locations.
Creators: name: Sánchez Paniagua, Inés
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Cancer
subject: Surgery
subject: Radiation therapy / Oncology
subject: Chemotherapy
subject: Nuclear medicine conventional
subject: MR
subject: CT
subject: Paediatric

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: -To describe the epidemiological and clinical characteristics of neuroblastoma. -To illustrate thecommon and uncommonlocations of neuroblastoma. -To show tumor characteristics using different imaging techniques: ultrasound, CT, MRI and NM. -To...
Successful en bloc venous resection with reconstruction and subsequent radiotherapy for 2 consecutive recurrences of intravenous leiomyoma—a case report
Creators: name: Clark, Leslie H
name: Zhou, Chunxiao
Publisher: name: BioMed Central
Year: 2016

description: Abstract Background Intravenous leiomyomas are a rare variant of uterine leiomyoma. Although histologically benign, these tumors are associated with a poor prognosis due to propensity for metastasis, high recurrence rate, difficulty of obtaining complete resection, and frequent extension into and along major veins. Case presentation We describe a 43-year-old patient initially presenting with lower abdominal pain. Clinical examination revealed a large right pelvic mass that was shown by computed tomography (CT) to surround the right external iliac vein, right common iliac vein and distal inferior vena cava. The patient had a history of total abdominal hysterectomy with bilateral ovarian cystectomies for uterine leiomyoma approximately 3 years prior to her presentation. Her past surgical history also included removal of an ovarian endometriosis cyst and right hydrosalpinx. The patient underwent an exploratory laparotomy. Operative findings included complete occlusion of the right iliac vessels and distal vena cava by a large tumor that filled the pelvis and extended to the level of the right kidney. The mass was resected en bloc with the involved veins and synthetic vascular grafts were placed. This highly technical procedure was complicated by hemorrhage requiring a total of 32 units of red blood cells and 2.0 L of plasma. Pathologic examination confirmed intravenous leiomyoma. On Immunohistochemical staining, the tumor cells were positive for CD32, CD34, Vimentin and smooth muscle actin. Eight months after this procedure, the patient again presented with an abdominal mass. She was diagnosed with a pelvic recurrence and noted to have intravascular extension into the left iliac vein and inferior vena cava. For this tumor she underwent radiation treatment with three-dimensional conformal radiation therapy (total dose 4500 cGy). The tumor gradually decreased in size during follow-up and became undetectable by CT. Conclusions Surgical excision is the mainstay of treatment of intravenous leiomyoma. Radiation therapy may be an effective alternative in patients with unresectable disease or poor surgical candidates.
A Comparison Between Global Proxies of the Sun's Magnetic Activity Cycle: Inferences from Helioseismology
Creators: name: Broomhall, A. -M.
name: Nakariakov, V. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The last solar minimum was, by recent standards, unusually deep and long. We are now close to the maximum of the subsequent solar cycle, which is relatively weak. In this article we make comparisons between different global (unresolved) measures of the Sun's magnetic activity, to investigate how they are responding to this weak-activity epoch. We focus on helioseismic data, which are sensitive to conditions, including the characteristics of the magnetic field, in the solar interior. Also considered are measures of the magnetic field in the photosphere (sunspot number and sunspot area), the chromosphere and corona (10.7cm radio flux and 530.3nm green coronal index), and two measures of the Sun's magnetic activity closer to Earth (the interplanetary magnetic field and the galactic cosmic-ray intensity). Scaled versions of the activity proxies diverge from the helioseismic data around 2000, indicating a change in relationship between the proxies. The degree of divergence varies from proxy to proxy with sunspot area and 10.7cm flux showing only small deviations, while sunspot number, coronal index, and the two interplanetary proxies show much larger departures. In Cycle 24 the deviations in the solar proxies and the helioseismic data decrease, raising the possibility that the deviations observed in Cycle 23 are just symptomatic of a 22-year Hale cycle. However, the deviations in the helioseismic data and the interplanetary proxies increase in Cycle 24. Interestingly the divergence in the solar proxies and the helioseismic data are not reflected in the shorter-term variations (often referred to as quasi-biennial oscillations) observed on top of the dominant 11-year solar cycle. However, despite being highly correlated in Cycle 22, the short-term variations in the interplanetary proxies show very little correlation with the helioseismic data during Cycles 23 and 24.
description: Accepted for publication in Solar Physics, 18 pages, 4 figures
Migalastat improves diarrhea in patients with Fabry disease: clinical-biomarker correlations from the phase 3 FACETS trial
Creators: name: Barth, Jay A
name: Shankar, Suma P
name: Skuban, Nina
name: Mulberg, Andrew
name: Giugliani, Roberto
name: Holdbrook, Fred
name: Barisoni, Laura
name: Colvin, Robert B
name: Jovanovic, Ana
name: Castelli, Jeffrey P
name: Bichet, Daniel G
name: Nicholls, Kathleen
name: Feldt-Rasmussen, Ulla
name: Schiffmann, Raphael
name: Hughes, Derralynn A
name: Jennette, Charles
Publisher: name: BioMed Central
Year: 2018

description: Abstract Background Fabry disease is frequently characterized by gastrointestinal symptoms, including diarrhea. Migalastat is an orally-administered small molecule approved to treat the symptoms of Fabry disease in patients with amenable mutations. Methods We evaluated minimal clinically important differences (MCID) in diarrhea based on the corresponding domain of the patient-reported Gastrointestinal Symptom Rating Scale (GSRS) in patients with Fabry disease and amenable mutations (N = 50) treated with migalastat 150 mg every other day or placebo during the phase 3 FACETS trial (NCT00925301). Results After 6 months, significantly more patients receiving migalastat versus placebo experienced improvement in diarrhea based on a MCID of 0.33 (43% vs 11%; p = .02), including the subset with baseline diarrhea (71% vs 20%; p = .02). A decline in kidney peritubular capillary globotriaosylceramide inclusions correlated with diarrhea improvement; patients with a reduction > 0.1 were 5.6 times more likely to have an improvement in diarrhea than those without (p = .031). Conclusions Migalastat was associated with a clinically meaningful improvement in diarrhea in patients with Fabry disease and amenable mutations. Reductions in kidney globotriaosylceramide may be a useful surrogate endpoint to predict clinical benefit with migalastat in patients with Fabry disease. Trial registration NCT00925301 ; June 19, 2009.
On the Effectiveness of Simhashing in Clone Detection on Large Scale Software System
Creators: Uddin, S.
Roy, C.K.
Schneider, K.A.
Hindle, Abram
Publisher: name: University of Alberta Library
Year: 2011

Clone detection techniques essentially cluster textually, syntactically and/or semantically similar code fragments in or across software systems. For large datasets, similarity identification is costly both in terms of time and memory, and especially so when detecting near-miss clones where lines could be modified, added and/or deleted in the copied fragments. The capability and effectiveness of a clone detection tool mostly depends on the code similarity measurement technique it uses. A variety of similarity measurement approaches have been used for clone detection, including fingerprint based approaches, which have had varying degrees of success notwithstanding some limitations. In this paper, we investigate the effectiveness of simhash, a state of the art fingerprint based data similarity measurement technique for detecting both exact and near-miss clones in large scale software systems. Our experimental data show that simhash is indeed effective in identifying various types of clones in a software system despite wide variations in experimental circumstances. The approach is also suitable as a core capability for building other tools, such as tools for: incremental clone detection, code searching, and clone management.
Cav3.2 calcium channel interactions with the epithelial sodium channel ENaC
Creators: name: Gandini, Maria A
name: Souza, Ivana A
name: Huang, Shuo
name: Zamponi, Gerald W
name: Chen, Lina
name: Garcia-Caballero, Agustin
name: Dang, Yan L
name: Stutts, M. J
Publisher: name: BioMed Central
Year: 2019

description: Abstract
              This study describes the functional interaction between Cav3.2 calcium channels and the Epithelial Sodium Channel (ENaC). β-ENaC subunits showed overlapping expression with endogenous Cav3.2 calcium channels in the thalamus and hypothalamus as detected by immunostaining. Moreover, β- and γ-ENaC subunits could be co-immunoprecipitated with Cav3.2 calcium channels from brain lysates, dorsal horn and lumbar dorsal root ganglia. Mutation of a cluster of lysines present in the intracellular N-terminus region of β-ENaC (K4R/ K5R/ K9R/ K16R/ K23R) reduced interactions with Cav3.2 calcium channels. Αβγ-ENaC channels enhanced Cav3.2 calcium channel trafficking to the plasma membrane in tsA-201 cells. This effect was reciprocal such that Cav3.2 channel expression also enhanced β-ENaC trafficking to the cell surface. T-type current density was increased when fully assembled αβγ-ENaC channels were transiently expressed in CAD cells, a neuronal derived cell line. Altogether, these findings reveal ENaC as an interactor and potential regulator of Cav3.2 calcium channels expressed in neuronal tissues.
Training Deep Convolutional Networks with Unlimited Synthesis of Musical Examples for Multiple Instrument Recognition
Creators: Sethi, R.
Weninger, N.
Hindle, Abram
Bulitko, V.
Frishkopf, M.
Publisher: name: University of Alberta Library
Year: 2018

Deep learning has yielded promising results in music information retrieval and other domains compared to machine learning algorithms trained on hand-crafted feature representations, but is often limited by the availability of data and vast hyper-parameter space. It is difficult to obtain large amounts of annotated recordings due to prohibitive labelling costs and copyright restrictions. This is especially true when the MIR task is low-level in nature such as instrument recognition and applied to wide ranges of world instruments, causing most MIR techniques to focus on recovering easily verifiable metadata such as genre. We tackle this data availability problem using two techniques: generation of synthetic recordings using MIDI files and synthesizers, and by adding noise and filters to the generated samples for data augmentation purposes. We investigate the application of deep synthetically trained models to two related low-level MIR tasks of frame-level polyphony detection and instrument classification in polyphonic recordings, and empirically show that deep models trained on synthetic recordings augmented with noise can outperform a majority class baseline on a dataset of polyphonic recordings labeled with predominant instruments.
title: The role of multimodality imaging in Multiple Myeloma: Past, Present and Future
Creators: name: Gil, Rui
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Haematologic
subject: Oncology
subject: Musculoskeletal bone
subject: MR-Diffusion/Perfusion
subject: Conventional radiography
subject: PET-CT
subject: Education
subject: Staging
subject: Education and training
subject: Haematologic diseases

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To review the established uses of radiography, computed tomography, magnetic resonance imaging and nuclear medicine in the assessment of multiple myeloma; To illustrate the key imaging modalities and findings for multiple myeloma; To discuss current...