title: ÐÐ¸Ð¾ÑÐ¾Ð²Ð¼ÐµÑÑÐ¸Ð¼Ð¾ÑÑÑ Ð¸Ð½ÑÐµÑÐ°ÐºÑÐ¸Ð²Ð½ÑÑ /Ð±Ð¸Ð¾Ð°ÐºÑÐ¸Ð²Ð½ÑÑ ÑÐ°Ð½ÐµÐ²ÑÑ Ð¿Ð¾ÐºÑÑÑÐ¸Ð¹ Ð² ÑÑÐ»Ð¾Ð²Ð¸ÑÑ in vitro
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: The biocompatibility of interactive/bioactive wound dressings under in vitro conditions
Creators: name: ÐÐ°Ð¿Ð¸Ð½Ð°, ÐÐºÐ°ÑÐµÑÐ¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: Ð³Ð¸Ð´ÑÐ¾Ð³ÐµÐ»ÐµÐ²ÑÐµ ÐºÐ¾Ð»Ð»Ð°Ð³ÐµÐ½Ð¾Ð²ÑÐµ ÑÐ°Ð½ÐµÐ²ÑÐµ Ð¿Ð¾ÐºÑÑÑÐ¸Ñ
Ð±Ð¸Ð¾ÑÐ¾Ð²Ð¼ÐµÑÑÐ¸Ð¼Ð¾ÑÑÑ
Ð°Ð½ÑÐ¸ÑÐµÐ¿ÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÑ
ÑÐºÐ²Ð¸Ð²Ð°Ð»ÐµÐ½ÑÑ ÐºÐ¾Ð¶Ð¸
ÑÑÐ¸Ð²Ð°ÑÑÐ¸Ðµ Ð°Ð³ÐµÐ½ÑÑ
hydrogel collagen wound dressings
biocompatibility
antiseptic drugs
skin substitutes
crosslinking agents

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ñ Ð¸Ð½ÑÐµÑÐ°ÐºÑÐ¸Ð²Ð½ÑÑ/Ð±Ð¸Ð¾Ð°ÐºÑÐ¸Ð²Ð½ÑÑ ÐºÐ¾Ð»Ð»Ð°Ð³ÐµÐ½Ð¾Ð²ÑÑ Ð³Ð¸Ð´ÑÐ¾Ð³ÐµÐ»ÐµÐ²ÑÑ ÑÐ°Ð½ÐµÐ²ÑÑ Ð¿Ð¾ÐºÑÑÑÐ¸Ð¹ (Ð Ð), Ð¸ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¸Ñ Ð±Ð¸Ð¾ÑÐ¾Ð²Ð¼ÐµÑÑÐ¸Ð¼Ð¾ÑÑÐ¸ Ð² ÑÑÐ»Ð¾Ð²Ð¸ÑÑ in vitro. Ð ÑÐ°Ð±Ð¾ÑÐµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð»Ð¸ ÐºÐ¾Ð»Ð»Ð°Ð³ÐµÐ½Ð¾Ð²ÑÐµ Ð³Ð¸Ð´ÑÐ¾Ð³ÐµÐ»Ð¸ (ÐÐ), Ð¼Ð¾Ð´Ð¸ÑÐ¸ÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐµ ÑÑÐ¸Ð²Ð°ÑÑÐ¸Ð¼Ð¸ Ð°Ð³ÐµÐ½ÑÐ°Ð¼Ð¸ (Ð¡Ð), ÑÐ°ÐºÐ¸Ð¼Ð¸ ÐºÐ°Ðº 1-Ð­ÑÐ¸Ð»-3-(3-Ð´Ð¸Ð¼ÐµÑÐ¸Ð»Ð°Ð¼Ð¸Ð½Ð¾Ð¿ÑÐ¾Ð¿Ð¸Ð») ÐºÐ°ÑÐ±Ð¾Ð´Ð¸Ð¸Ð¼Ð¸Ð´, Ð³Ð°Ð»Ð»Ð¾Ð²Ð°Ñ ÐºÐ¸ÑÐ»Ð¾ÑÐ° Ð¸ ÑÐ¸Ð±Ð¾ÑÐ»Ð°Ð²Ð¸Ð½, Ð° ÑÐ°ÐºÐ¶Ðµ ÐºÐ¾Ð»Ð»Ð°Ð³ÐµÐ½Ð¾Ð²ÑÐµ Ð³Ð¸Ð´ÑÐ¾Ð³ÐµÐ»Ð¸, Ð½ÐµÑÑÑÐ¸Ðµ Ð°Ð½ÑÐ¸ÑÐµÐ¿ÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÑ (ÑÐ»Ð¾ÑÐ³ÐµÐºÑÐ¸Ð´Ð¸Ð½, Ð¼Ð¸ÑÐ°Ð¼Ð¸ÑÑÐ¸Ð½, Ð¿Ð¾Ð²Ð¸Ð´Ð¾Ð½-Ð¹Ð¾Ð´ Ð¸ ÑÑÑÐ°ÑÐ¸Ð»Ð¸Ð½). Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð±ÑÐ»Ð¸ Ð¿Ð¾Ð´Ð¾Ð±ÑÐ°Ð½Ñ Ð¾Ð¿ÑÐ¸Ð¼Ð°Ð»ÑÐ½ÑÐµ ÑÑÐ»Ð¾Ð²Ð¸Ñ Ð´Ð»Ñ Ð²ÑÐ¼ÑÐ²Ð°Ð½Ð¸Ñ Ð¾ÑÑÐ°ÑÐ¾ÑÐ½ÑÑ ÐºÐ¾Ð½ÑÐµÐ½ÑÑÐ°ÑÐ¸Ð¹ ÑÑÐ¸Ð²Ð°ÑÑÐ¸Ñ Ð°Ð³ÐµÐ½ÑÐ¾Ð² Ð¸Ð· ÑÑÑÑÐºÑÑÑÑ Ð¼Ð¾Ð´Ð¸ÑÐ¸ÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð³Ð¾ ÐÐ Ð´Ð»Ñ Ð¾Ð±ÐµÑÐ¿ÐµÑÐµÐ½Ð¸Ñ ÐµÐ³Ð¾ Ð±Ð¸Ð¾ÑÐ¾Ð²Ð¼ÐµÑÑÐ¸Ð¼Ð¾ÑÑÐ¸ Ñ ÐºÐ»ÐµÑÐºÐ°Ð¼Ð¸ ÐºÐ¾Ð¶Ð¸. Ð¡ÑÐ¾Ð¸Ñ Ð¾ÑÐ¼ÐµÑÐ¸ÑÑ, ÑÑÐ¾ Ð² ÑÐ°Ð±Ð¾ÑÐµ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð½Ð¾ Ð¾ÑÑÑÑÑÑÐ²Ð¸Ðµ Ð½ÐµÐ³Ð°ÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð²Ð»Ð¸ÑÐ½Ð¸Ñ ÑÐ´Ð°Ð»ÐµÐ½Ð¸Ñ Ð¾ÑÑÐ°ÑÐ¾ÑÐ½ÑÑ ÐºÐ¾Ð½ÑÐµÐ½ÑÑÐ°ÑÐ¸Ð¹ Ð¡Ð Ð½Ð° Ð¸Ñ ÑÑÐ°Ð±Ð¸Ð»Ð¸Ð·Ð¸ÑÑÑÑÐ¸Ð¹ ÑÑÑÐµÐºÑ. Ð¢Ð°ÐºÐ¶Ðµ Ð±ÑÐ»Ð¸ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ñ Ð¾Ð¿ÑÐ¸Ð¼Ð°Ð»ÑÐ½ÑÐµ Ð¾Ð±ÑÑÐ¼Ñ Ð°Ð½ÑÐ¸ÑÐµÐ¿ÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ¾Ð², ÐºÐ¾ÑÐ¾ÑÑÐµ Ð¼Ð¾Ð¶Ð½Ð¾ Ð´Ð¾Ð±Ð°Ð²Ð¸ÑÑ Ð² ÐÐ, ÑÑÐ¾Ð±Ñ Ð¾Ð½ Ð¾ÑÑÐ°Ð²Ð°Ð»ÑÑ Ð±Ð¸Ð¾ÑÐ¾Ð²Ð¼ÐµÑÑÐ¸Ð¼ÑÐ¼. ÐÐ¸Ð¾ÑÐ¾Ð²Ð¼ÐµÑÑÐ¸Ð¼Ð¾ÑÑÑ ÑÐ°Ð·ÑÐ°Ð±Ð°ÑÑÐ²Ð°ÐµÐ¼ÑÑ ÐºÐ¾Ð»Ð»Ð°Ð³ÐµÐ½Ð¾Ð²ÑÑ Ð³Ð¸Ð´ÑÐ¾Ð³ÐµÐ»ÐµÐ²ÑÑ Ð Ð Ð¾ÑÐµÐ½Ð¸Ð²Ð°Ð»Ð¸ Ð¿Ð¾ ÑÑÐ¾Ð²Ð½Ñ Ð¶Ð¸Ð·Ð½ÐµÑÐ¿Ð¾ÑÐ¾Ð±Ð½Ð¾ÑÑÐ¸ (ÐÐ¢Ð¢-ÑÐµÑÑ) ÐºÐ»ÐµÑÐ¾Ðº ÐºÐ¾Ð¶Ð¸, ÐºÑÐ»ÑÑÐ¸Ð²Ð¸ÑÑÐµÐ¼ÑÑ Ð² 2D Ð¸ 3D (Ð² ÑÐ¾ÑÑÐ°Ð²Ðµ Ð´ÐµÑÐ¼Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ Ð¸ ÑÐ¿Ð¸Ð´ÐµÑÐ¼Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ ÑÐºÐ²Ð¸Ð²Ð°Ð»ÐµÐ½ÑÐ¾Ð² ÐºÐ¾Ð¶Ð¸) ÑÑÐ»Ð¾Ð²Ð¸ÑÑ Ð² Ð¿ÑÐ¸ÑÑÑÑÑÐ²Ð¸Ð¸ ÑÐ°Ð·ÑÐ°Ð±Ð°ÑÑÐ²Ð°ÐµÐ¼ÑÑ Ð Ð Ð¸Ð»Ð¸ Ð²ÑÑÑÐ¶ÐµÐº Ð¸Ð· Ð½Ð¸Ñ. Ð¡Ð¾Ð·Ð´Ð°Ð½Ð½ÑÐµ Ð² ÑÐ°Ð¼ÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÑ Ð¸Ð½ÑÐµÑÐ°ÐºÑÐ¸Ð²Ð½ÑÐµ/Ð±Ð¸Ð¾Ð°ÐºÑÐ¸Ð²Ð½ÑÐµ Ð Ð Ð¾Ð±Ð»Ð°Ð´Ð°ÑÑ Ð²ÑÑÐ¾ÐºÐ¾Ð¹ Ð±Ð¸Ð¾ÑÐ¾Ð²Ð¼ÐµÑÑÐ¸Ð¼Ð¾ÑÑÑÑ in vitro Ð¸ Ð¼Ð¾Ð³ÑÑ Ð±ÑÑÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ñ Ð´Ð»Ñ ÑÐµÑÐµÐ½Ð¸Ñ Ð·Ð°Ð´Ð°Ñ ÑÐµÐ³ÐµÐ½ÐµÑÐ°ÑÐ¸Ð²Ð½Ð¾Ð¹ Ð¼ÐµÐ´Ð¸ÑÐ¸Ð½Ñ.
description: The given work is devoted to the development of interactive/bioactive collagen hydrogel wound dressings (WD) and the investigation of their biocompatibility in vitro.Â We studied collagen hydrogels (CH), which were modified with crosslinking agents (CA), such as 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide, gallic acid, and riboflavin. Additionally, we investigated collagen hydrogels that contained antiseptic drugs, including chlorhexidine, miramistin, povidone iodine, and furacilin. As a result of our research, we identified optimal conditions for removing residual crosslinking agent concentrations from the modified CH structure to ensure its compatibility with skin cells. Notably, our findings indicate that removing these residual concentrations doesnât negatively impact the stabilizing effect of the CA. We also determined the optimal volumes of antiseptic drags that can be incorporated into KG while maintaining its biocompatibility. The biocompatibility of the developed collagen hydrogel WD was assessed by measuring the viability of skin cells grown in 2D and 3D conditions (as part of dermal and epidermal skin equivalents), in the presence of WD or itsâ extracts. The WD developed as part of this work exhibits high biocompatibility in vitro and has the potential to be used in regenerative medicine applications.