title: Ð­ÐºÑÐ¿ÑÐµÑÑÐ¸Ñ Ð³ÐµÐ½Ð¾Ð² ÑÐµÑÐµÐ¿ÑÐ¾ÑÐ¾Ð², Ð°ÐºÑÐ¸Ð²Ð¸ÑÑÐµÐ¼ÑÑ Ð¿ÑÐ¾Ð»Ð¸ÑÐµÑÐ°ÑÐ¾ÑÐ¾Ð¼ Ð¿ÐµÑÐ¾ÐºÑÐ¸ÑÐ¾Ð¼, Ð² Ð»Ð¸ÑÐ¸Ð¹-Ð¿Ð¸Ð»Ð¾ÐºÐ°ÑÐ¿Ð¸Ð½Ð¾Ð²Ð¾Ð¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð²Ð¸ÑÐ¾ÑÐ½Ð¾Ð¹ ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ð¸ Ñ ÐºÑÑÑ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Expression of receptor genes activated by proliferator peroxisom, in lithium-pilocarpine models of temporal lobe epilepsy in rats
Creators: name: Ð Ð¾Ð³Ð¸Ð½ÑÐºÐ°Ñ, ÐÐ½Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: PPARÎ±
PPARÎ²
PPARÎ³
bifidobacterium longum
ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ñ
Ð²Ð¸ÑÐ¾ÑÐ½Ð°Ñ ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ñ
Ð»Ð¸ÑÐ¸Ð¹-Ð¿Ð¸Ð»Ð¾ÐºÐ°ÑÐ¿Ð¸Ð½Ð¾Ð²Ð°Ñ Ð¼Ð¾Ð´ÐµÐ»Ñ
epilepsy
temporal lobe epilepsy
lithium-pilocarpine model

description: Â Ð Ð°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð³ÐµÐ½Ð¾Ð² ÑÐµÑÐµÐ¿ÑÐ¾ÑÐ¾Ð², Ð°ÐºÑÐ¸Ð²Ð¸ÑÑÐµÐ¼ÑÑ Ð¿ÑÐ¾Ð»Ð¸ÑÐµÑÐ°ÑÐ¾ÑÐ¾Ð¼ Ð¿ÐµÑÐ¾ÐºÑÐ¸ÑÐ¾Ð¼, PPARÎ±, PPARÎ², PPARÎ³ Ð² ÐºÐ»ÐµÑÐºÐ°Ñ Ð¼Ð¾Ð·Ð³Ð° ÐºÑÑÑ Ð² Ð»Ð¸ÑÐ¸Ð¹-Ð¿Ð¸Ð»Ð¾ÐºÐ°ÑÐ¿Ð¸Ð½Ð¾Ð²Ð¾Ð¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð²Ð¸ÑÐ¾ÑÐ½Ð¾Ð¹ ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ð¸. Ð Ð°Ð±Ð¾ÑÐ° Ð²ÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð° Ð½Ð° Ð±Ð°Ð·Ðµ ÐÐ°Ð±Ð¾ÑÐ°ÑÐ¾ÑÐ¸Ð¸ Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½ÑÑ Ð¼ÐµÑÐ°Ð½Ð¸Ð·Ð¼Ð¾Ð² Ð½ÐµÐ¹ÑÐ¾Ð½Ð½ÑÑ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ð¹ ÐÐ­Ð¤Ð Ð ÐÐ.Ð Ð°Ð±Ð¾ÑÐ° Ð²ÐºÐ»ÑÑÐ°Ð»Ð° Ð´Ð²Ðµ ÑÐµÑÐ¸Ð¸ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ¾Ð²: Ð² Ð¿ÐµÑÐ²Ð¾Ð¹ ÑÐ°ÑÑÐ¸ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð»Ð°ÑÑ Ð´Ð¸Ð½Ð°Ð¼Ð¸ÐºÐ° ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð³ÐµÐ½Ð¾Ð² ÑÐµÑÐµÐ¿ÑÐ¾ÑÐ¾Ð², Ð°ÐºÑÐ¸Ð²Ð¸ÑÑÐµÐ¼ÑÑ Ð¿ÑÐ¾Ð»Ð¸ÑÐµÑÐ°ÑÐ¾ÑÐ¾Ð¼ Ð¿ÐµÑÐ¾ÐºÑÐ¸ÑÐ¾Ð¼, Ð² Ð»Ð¸ÑÐ¸Ð¹-Ð¿Ð¸Ð»Ð¾ÐºÐ°ÑÐ¿Ð¸Ð½Ð¾Ð²Ð¾Ð¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸ ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ð¸ Ð½Ð° ÑÑÐ¾Ð²Ð½Ðµ Ð¼Ð ÐÐ Ð¼ÐµÑÐ¾Ð´Ð¾Ð¼ ÐÐ¦Ð  Ð² ÑÐµÐ°Ð»ÑÐ½Ð¾Ð¼ Ð²ÑÐµÐ¼ÐµÐ½Ð¸ Ð¸ Ð½Ð° ÑÑÐ¾Ð²Ð½Ðµ Ð±ÐµÐ»ÐºÐ° Ð¼ÐµÑÐ¾Ð´Ð¾Ð¼ Ð²ÐµÑÑÐµÑÐ½-Ð±Ð»Ð¾Ñ. ÐÐ¾ Ð²ÑÐ¾ÑÐ¾Ð¹ ÑÐ°ÑÑÐ¸ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ° Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð»Ð¸ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ Ð¿ÑÐ¾Ð±Ð¸Ð¾ÑÐ¸ÐºÐ° Bifidobacterium longum Ð½Ð° Ð²ÑÐ¶Ð¸Ð²Ð°ÐµÐ¼Ð¾ÑÑÑ ÐºÑÑÑ Ð² Ð»Ð¸ÑÐ¸Ð¹-Ð¿Ð¸Ð»Ð¾ÐºÐ°ÑÐ¿Ð¸Ð½Ð¾Ð²Ð¾Ð¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð¸ Ð½Ð° ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ñ Ð³ÐµÐ½Ð¾Ð² ÑÐµÑÐµÐ¿ÑÐ¾ÑÐ¾Ð², Ð°ÐºÑÐ¸Ð²Ð¸ÑÑÐµÐ¼ÑÑ Ð¿ÑÐ¾Ð»Ð¸ÑÐµÑÐ°ÑÐ¾ÑÐ¾Ð¼ Ð¿ÐµÑÐ¾ÐºÑÐ¸ÑÐ¾Ð¼.ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð½Ð¾Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð²ÑÑÐ²Ð¸Ð»Ð¾ Ð´Ð¾ÑÑÐ¾Ð²ÐµÑÐ½Ð¾Ðµ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ðµ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð³ÐµÐ½Ð¾Ð² PPARÎ±, Î²/Î´, Î³ Ð½Ð° ÑÑÐ¾Ð²Ð½Ðµ Ð¼Ð ÐÐ Ð² Ð»Ð¸ÑÐ¸Ð¹-Ð¿Ð¸Ð»Ð¾ÐºÐ°ÑÐ¿Ð¸Ð½Ð¾Ð²Ð¾Ð¹ Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð²Ð¸ÑÐ¾ÑÐ½Ð¾Ð¹ ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸Ð¸. ÐÐ±Ð½Ð°ÑÑÐ¶ÐµÐ½Ñ Ð´Ð¾ÑÑÐ¾Ð²ÐµÑÐ½ÑÐµ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ PPARÎ± Ð¸ PPARÎ² Ð²Ð¾ Ð²ÑÐµÑ ÑÑÑÑÐºÑÑÑÐ°Ñ, Ð¾Ð´Ð½Ð°ÐºÐ¾ Ð´Ð¾ÑÑÐ¾Ð²ÐµÑÐ½ÑÑ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ð¹ ÑÐºÑÐ¿ÑÐµÑÐ¸Ð¸ PPARÎ³ Ð½Ðµ Ð¾Ð±Ð½Ð°ÑÑÐ¶ÐµÐ½Ð¾. ÐÐ²ÐµÐ´ÐµÐ½Ð¸Ðµ Ð¿ÑÐ¾Ð±Ð¸Ð¾ÑÐ¸ÐºÐ° Bifidobacterium longum Ð½Ð° ÑÑÐ¾Ð²Ð½Ðµ Ð¼Ð ÐÐ Ð²ÑÑÐ²Ð¸Ð»Ð¾ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ Ð²Ð²ÐµÐ´ÐµÐ½Ð¸Ñ Ð¿ÑÐ¾Ð±Ð¸Ð¾ÑÐ¸ÐºÐ° Ð½Ð° ÑÐ²ÐµÐ»Ð¸ÑÐµÐ½Ð¸Ðµ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ PPARg Ð² Ð²ÐµÐ½ÑÑÐ°Ð»ÑÐ½Ð¾Ð¼ Ð³Ð¸Ð¿Ð¿Ð¾ÐºÐ°Ð¼Ð¿Ðµ.ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ Ð´Ð°Ð½Ð½ÑÐµ Ð¼Ð¾Ð³ÑÑ Ð±ÑÑÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ñ Ð² ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐµ Ð½Ð¾Ð²ÑÑ Ð¼ÐµÑÐ¾Ð´Ð¾Ð² Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾ÑÐ¿Ð¸Ð»ÐµÐ¿ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸.
description: The topic of the final qualifying work: "Expression of receptor genes activated by the proliferator peroxisome in a lithium-pilocarpine model of temporal lobe epilepsy in rats".Â The work is devoted to the study of gene expression of receptors activated by the proliferator peroxisome, PPARa, PPARÃ, PPARy in rat brain cells in a lithium-pilocarpine model of temporal lobe epilepsy. The work was carried out on the basis of the Laboratory of Molecular Mechanisms of Neural Interactions of the IEFB RAS.Â The work included two series of experiments: in the first part, the dynamics of gene expression of receptors activated by the peroxisome proliferator was studied in a lithium-pilocarpine model of epilepsy at the mRNA level by real- time PCR and at the protein level by Western blot. In the second part of the experiment, the effect of the probiotic Bifidobacterium longum on the survival of rats in a lithium-pilocarpine model and on the expression of receptor genes activated by the proliferator peroxisome was investigated.Â Â The study revealed a significant change in the expression of the PPARa, Î²/Î´, Î³ genes at the mRNA level in the lithium-pilocarpine model of temporal epilepsy. Significant changes in PPARa and PPARÃ were found in all structures, but no significant changes in the expression of PPARy were found. Administratio-n of the probiotic Bifidobacterium longum at the mRNA level revealed the effect of probiotic administration on an increase in PPARg expression in the ventral hippocampus.Â Â The data obtained can be used in the development of new methods of antiepileptic therapy.Â