cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Increasing the Quantum Yield of Red Fluorescent Proteins Using Rational Design
Creators: name: Pandelieva, Antonia
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: rational design
red fluorescent protein (RFP)
quantum yield
extinction coefficient
brightness
crystallography

description: Monomeric red fluorescent proteins (RFPs) are used extensively for applications in molecular biology research, and are especially suited for whole body imaging applications due to their longer excitation and emission wavelengths, which are less damaging and penetrate deeper into animal tissue. However, these proteins suffer from reduced brightness compared to other fluorescent proteins, and require further engineering, which is often achieved through random methods, incurring large time and resource costs. Here we propose a rational design approach to improve the quantum yield of RFPs by reducing conformational variability of the chromophore. We engineered mRojoA, a mutant containing a π-stack involving Tyr197 and the chromophore phenolate, to include the P63F/H/Y mutations on its other side, by simultaneously mutating neighbouring positions 16, 143, and 163. The brightest mutants that we found in each library, mRojo-VYGV, mRojo-VFAV, and mRojo-VHSV, exhibited 1.8- to 2.4-fold increases in brightness, and quantum yield increases of up to 2.1-fold. In all three mutants, the increases in brightness were predominantly due to improvements in the quantum yield and not the extinction coefficient. Solving the crystal structures of two of these mutants along with a dim variant allowed us to strongly infer a link between rigidity of the chromophore and increased quantum yield. In addition, back-mutating position 63 in the highest quantum yield mutant, mRojo-VYGV, reversed the improvement in quantum yield, indicating that Y63 was the primary residue responsible for the improved brightness of the protein. Unfortunately, the mCherry-VYGV mutant did not achieve a similar increase in quantum yield or brightness. This is likely due to the lack of a second bulky aromatic residue at position 197, which is present in mRojoA. Nevertheless, this rational approach could be applied to some other RFPs whose chromophores exhibit increased conformational variability in order to further improve their brightness.
Effectiveness of a Mindfulness-Based Intervention for Athletes
Creators: name: Jekauc, Darko
name: Kittler, Christoph
name: Schlagheck, Marcel
Publisher: name: Humboldt-Universität zu Berlin
Year: 2017
Subjects: subject: Mindfulness
subject: Intervention
subject: Athletes
subject: Sport Psychology
subject: Randomized Trial
subject: 790 Freizeitgestaltung, darstellende Künste, Sport

description: Recently, several top athletes, as well as coaches, have revealed that mindfulness can be regarded as a type of psychological training to optimize performance. Indeed, results of studies in clinical psychology, as well as neuroscience, suggest that mindfulness might be an effective strategy to promote concentration, emotion regulation and state of flow. However, the empirical evidence in the context of sport is rather sparse. The aim of this study was to examine the effectiveness of a mindfulness-based intervention in athletes. In a randomized controlled trial with 22 participants in the experimental and 24 participants in the control group, the effectiveness of the Berlin Mindfulness-based Training for Athletes (BATL) was tested and compared to a classical sport psychological intervention. The results of an analysis of covariance with repeated measures indicate that the intervention group significantly improved mindfulness as a trait compared to the control group. It can be concluded that BATL is an effective strategy to increase mindfulness in athletes. However, further studies are needed to evaluate the effectiveness of this intervention in improving performance and to be able to examine its effect mechanisms.
Three Essays on Research Joint Ventures, Coordination Costs and Environmental R&D
Creators: name: Rahimi, Armaghan
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Research and Development(R&D)
Research Joint Venture (RJV)
Coordination Costs

description: This dissertation is about research and development (R&D) and formation of research joint ventures (RJV). The first chapter analyzes R&D competition and cooperation regimes with coordination costs under full information sharing and no spillovers in a Stackelberg model. The findings show that profits and R&D incentives of RJV members decrease with coordination costs. R&D cooperation of leaders results in higher profits for insiders and also higher welfare compared with R&D competition. Checking the robustness of the results shows that with R&D spillovers and no information sharing no RJV forms. With convex costs, an RJV containing all leaders forms. The second chapter considers a duopoly Cournot model where production may result in environmental damage. Firms can either invest in process or environmental R&D. In the first case, we assume an exogenous emission tax. With high enough emission tax, welfare is always higher under public R&D than cooperation. Under endogenous emission tax, when the regulator acts before firms’ decision on R&D, with high R&D spillovers, public R&D yields higher welfare than R&D cooperation. When the regulator sets the emission tax after firms’ decision on R&D, welfare under R&D cooperation is higher than public R&D. Comparison of commitment and no commitment also shows that commitment increases private R&D. Chapter three investigates the endogenous formation of coalitions under the size announcement game in a Cournot framework and analyzes the effect of coordination costs on equilibrium and optimal coalitions. When there are industry-wide R&D spillovers numerical simulations show that with high enough coordination costs no RJV forms in equilibrium, which also maximizes welfare. When there is intra coalition full information sharing and no inter-coalitions R&D spillovers with high enough coordination costs, the equilibrium coalition structure is more concentrated than when coordination costs are low and the size is higher than when RJVs could not form endogenously. Also, with high enough coordination costs, the welfare maximizing coalition is less concentrated than the equilibrium one while the opposite is true for low coordination costs.
A Conceptual Framework to Guide the Design, Delivery and Evaluation of Quality Mobile Learning Experiences
Creators: name: Kellam, Hugh James Dowler
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: mobile learning
conceptual framework
mobile learning experience
informal learning
mobile learning evaluation

description: Mobile learning has the pedagogical potential to provide informal, context-based educational experiences that can teach practical and applicable workplace skills and behaviors. The goal of this study was to examine the learning experiences and outcomes of healthcare professionals as they participated in a mobile learning activity designed to teach them the technical and procedural skills for facilitating clinical consultations via videoconference. The primary research question was: How does the use of a curriculum framework to design mobile learning experiences impact the learning experiences and outcomes of healthcare professionals with regards to developing workplace skills and understanding clinical processes? Informed by a systematic review of the mobile learning literature, this dissertation proposed a conceptual framework to guide the implementation and evaluation of mobile learning based on five dimensions of instructional design: content, structure, delivery, usability and communities of practice. Physicians, nurses and healthcare administrators voluntarily participated in this pragmatic, mixed methods study. Their quantitative and qualitative feedback was utilized both to assess the validity of the proposed mobile learning experience conceptual framework as well as its quantitative and qualitative evaluation tools. The study found that informal, contextual mobile learning content can promote communication and collaboration among healthcare professionals, and provide them with hands-on learning experiences that can be easily situated in a specific workplace environment. Delivery was identified as perhaps the most critical element in increasing motivation and interactivity among participants, and communities of practice after the learning activity were found to increase collaboration and provide opportunities for problem-solving. The structure of embedding the informal mobile learning experience within a formal, didactic online learning course was also found by participants to provide the right mix of background knowledge and practical application to produce meaningful learning outcomes. Overall, the mobile learning experience conceptual framework synthesizes best practices in the literature and proposes innovative methods for the design and evaluation of effective mobile learning.
The Impact of Military Status on Maternal and Child Outcomes In a Canadian Sample of Young Children
Creators: name: Tupper, Rachel
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Military Families
Child Attachment
Behaviour Problems

description: In the last decade, global instability has led to higher demands placed on military members and their families, especially in the area of deployment. Longer and more frequent deployments have had significant psychological consequences on soldiers who have been deployed. Deployment has also been shown to negatively impact child adjustment; however, the research in this area is limited, particularly within a Canadian military context. The purpose for the two current studies was to examine specific areas of child adjustment affected by military status, particularly deployment, and to explore potential pathways through which this impact occurs. Study 1 included an examination of the effect of military status on maternal depressive symptoms, parental stress, and marital satisfaction, as well as on the quality of the child's attachment to the parent at home. Further analyses were conducted to determine if maternal well-being mediated the effect of military status on attachment, and if there was a moderating role of social support on these associations. In Study 2, the unique role of military status in predicting reported behaviour problems over and above what was accounted for by child attachment and parental stress was explored. Findings from these studies revealed an association between deployment and higher levels of insecure attachment; and although deployment modestly predicted maternal depressive symptoms, there was no mediating effect found for maternal well-being. Furthermore, while insecure attachment and higher levels of parental stress were associated with elevated behaviour problems, deployment uniquely predicted conduct problems, internalizing problems, and total behaviour problems. Findings from the current studies add a valuable contribution to the limited available literature on how deployment affects young children in military families. Moreover these findings provide a basis in which to direct further research, and to also guide the development and implementation of interventions to support at-risk children in military families.
title: Duiféi chanpin hé zhao zha de zhìliàng baozhèng
title: Quality assurance of compost and digestate
titleType: AlternativeTitle
Creators: name: Dollhofer, Marie
name: Zettl, Elisabeth
Publisher: name: Umweltbundesamt
Year: 2018
Subjects: Kompost
Biogasgülle
Biomüllbewirtschaftung
Bioabfall
Kompostierung

description: Establishing a quality assurance system for compost and digestate from bio-waste can help to decrease the amount of biodegradable waste being landfilled and to increase material recycling. Germany has been successfully operating such a system since 1989, comprising also an organisation with the competence to control the quality of compost and digestate and to award a quality label, the Bundesgütegemeinschaft Kompost e.V. This brochure introduces to the quality assurance system of compost and digestate in Germany in order to give orientation and to share experiences. It provides information, inter alia, on the legal framework related to bio-waste in the EU and in Germany, on involved organisations and on requirements. This brochure is available in English and in Chinese. Quelle: http://www.umweltbundesamt.de
Supplementary document for Noble metal modified ReS2 nanocavity for surface-enhanced Raman spectroscopy (SERS) analysis - 5330881.pdf
Creators: name: Shao, MingRui
name: Zhang, C
name: Yu, Jing
name: Jiang, Shouzhen
name: Zhao, Xiaofei
name: Li, Zhaoxiang
name: Lu, Weixi
name: man, yuan
name: Li, Zhen
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement 1: Supplementary data results
Technical machines and evolution
Creators: name: Barnet, Belinda
Publisher: name: Swinburne
Year: 2024

description: How does one tell the story of a machine? Can we say that technical machines have their own genealogies, their own evolutionary dynamic? The technical artifact constitutes a series of objects, a lineage or a line. At a cursory level, we can see this in the fact that technical machines come in generations; they adapt and adopt characteristics over time, 'one suppressing the other as it becomes obsolete.'[2] So are we to understand this dynamic from a biological, a zoological or a sociological perspective? I want to locate a dynamic in technics that stems neither from the soul nor from human societies, which grants the technical object its own materiality, its own limits and resistances, which allows us to think technical objects in their historical differentiations. This calls for a new consideration of technicity, and a new consideration of the human being in relation to technics. The task will be difficult -- 'at its very origin and up until now, philosophy has repressed technics as an object of thought. Technics is the unthought.'[3] This essay will be a collection of notes towards such a perspective; it will be a prolegomena to the history of a technical machine, a history which is not included here and which has yet to be written. In this essay I will be exploring the work of Bernard Stiegler in relation to technicity and to human thought, but my task will not be to invert the history of philosophy itself, to 'imagine the human as what is invented' by technics.[4] I do not wish to put forward a theory of human evolution. My intention is much narrower, or perhaps more jaded; I want to clear a space in which a technical object might evolve, and in which I might trace such an evolution.
La connaissance des situations et des règles d’expression de colère chez l’enfant
Creators: name: Pinard, Fanny
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: émotion
enfant
colère
règles d'expression émotionnelle

description: Un certain nombre de recherches antérieures se sont intéressées à la connaissance qu’ont les enfants des situations et des motivations pour dissimuler la joie et la tristesse. Cependant, les études ciblant la colère et les raisons pour l’exprimer demeurent peu nombreuses. L’objectif général de la thèse était d’examiner la perception des enfants d’âge scolaire des situations et des règles d’expression de colère. Dans un premier temps, nous visions à produire un inventaire de thèmes évocateurs de colère représentatifs du vécu des enfants, en plus de documenter la connaissance des règles d’expression de la colère ainsi que les facteurs qui l’influencent. Nous avons interrogé 93 participants : 16 garçons et 18 filles de 7 ans, 16 garçons et 18 filles de 9 ans, et 11 garçons et 14 filles de 11 ans. Ceux-ci fournissaient des exemples de situations de colère lors d’interactions avec différents agents: pair familier, pair peu familier, adulte familier et adulte peu familier. Ils indiquaient ensuite l’intensité de la colère ressentie, leur expression faciale, ainsi que la motivation pour l’expression et pour la dissimulation. Les thèmes «restrictions comportementales», «contrainte à effectuer une tâche» et «refus de répondre à une demande» ont été mentionnés plus souvent lorsque l’agent était un adulte, alors que les thèmes «agression physique/ver
Problématique du choix thérapeutique : application multicritère au cas de la fibrillation auriculaire (FA)
Creators: name: Kabura, Emmanuel
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: Aide multicritère à la décision
choix thérapeutique
Analyse multicritère
problème décisionnel
fibrillation auriculaire (FA)
efficacité
sécurité
fonction rénale
observance
prix
Dabigatran
Apixaban

description: Trois essais cliniques ARISTOTLE, RE-LY et ROCKET-AF, sont réalisés sur les quatre nouveaux anticoagulants oraux qui sont l’Apixaban, le Dabigatran 110mg, Dabigatran 150mg et le Rivaroxaban, afin d’améliorer la prise en charge de la fibrillation auriculaire (FA). Ils ne permettent pas de déterminer la meilleure option thérapeutique. L’objectif de cette thèse est de développer une approche d’aide multicritère à la décision pour la problématique du choix thérapeutique appliquée au cas de la FA afin d’évaluer ces quatre options thérapeutiques médicamenteuses. La méthodologie d’aide multicritère développée, PROMETHEE-GAIA appliquée à la FA permet de comparer ces quatre nouveaux anticoagulants (l’Apixaban, le Dabigatran 110mg, Dabigatran 150mg et le Rivaroxaban) en se basant sur les cinq critères essentiels élaborés selon un processus de concertation cadrée, qui sont l’efficacité, la sécurité, la fonction rénale, l’observance et le prix. Les résultats de l’évaluation de ces quatre nouveaux anticoagulants est un classement de ces options thérapeutiques par leur ordre de performance dans la prise en charge des patients de la FA selon ces cinq critères en considération.
Supplementary document for Increase in terahertz-wave generation by difference frequency mixing by overlap of exciton states in different GaAs/AlAs quantum wells and spectroscopic measurements - 5331472.pdf
Creators: name: Kojima, Osamu
name: Sakaue, Kanta
name: Kita, Takashi
name: Steer, Matthew
name: Hogg, Richard
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: FigsS1-S3
Development of Point-of-Care Biosensors for COVID-19
Creators: name: Choi, Jane Ru
Publisher: name: Frontiers
Year: 2021

description: Coronavirus disease 2019 (COVID-19) outbreak has become a global pandemic. The deleterious effects of coronavirus have prompted the development of diagnostic tools to manage the spread of disease. While conventional technologies such as quantitative real time polymerase chain reaction (qRT-PCR) have been broadly used to detect COVID-19, they are time-consuming, labor-intensive and are unavailable in remote settings. Point-of-care (POC) biosensors, including chip-based and paper-based biosensors are typically low-cost and user-friendly, which offer tremendous potential for rapid medical diagnosis. This mini review article discusses the recent advances in POC biosensors for COVID-19. First, the development of POC biosensors which are made of polydimethylsiloxane (PDMS), papers, and other flexible materials such as textile, film, and carbon nanosheets are reviewed. The advantages of each biosensors along with the commercially available COVID-19 biosensors are highlighted. Lastly, the existing challenges and future perspectives of developing robust POC biosensors to rapidly identify and manage the spread of COVID-19 are briefly discussed.
Frame Analysis of Canadian Copyright Reform 2008-2012: From "Made-in-Canada" to a "Balanced Solution"
Creators: name: Rudkin, Aaron
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Copyright
Frame analysis
Policy reform
Public consultation
Canada
Digital locks
Intellectual property

description: From 2008-2012, the Harper government engaged in an effort to reform Canada's copyright legislation. This thesis uses a frame analysis approach to identify two distinct frames advanced by the government during this reform. 2008's Bill C-61 was unsuccessfully framed as a "Made-in-Canada" bill in order to combat opposition claims that American pressure unduly influenced the policy process. Following the failure of this bill, the government embarked on a public consultation on copyright. Although the government did not substantively modify subsequent reform bills, it was able to leverage the consultation process and Supreme Court of Canada jurisprudence to lend legitimacy to its new frame of the reform as a "balanced approach", build a coalition of support, and mitigate opposition. The thesis' analysis supports key conclusions of existing framing literature and creates a space for the role of ideas in the study of copyright reform in Canada.
Implications of the changed reporting requirements of the Effort Sharing Decision for the EU ETS and the national GHG inventory
Creators: name: Herold, Anke
name: Anderson, Graham
name: Jörß, Wolfram
Publisher: name: My University
Year: 2016
Subjects: Globale Emission
Emissionsinventar

description: This report analyses the technical provisions related to monitoring and reporting of greenhouse gas emissions under the EU ETS and the 2006 IPCC guidelines for national GHG inventories as of beginning 2014. Differences can lead to different reported CO2 (equivalent) emissions under the EU ETS and in the GHG inventory. Some of these issues may also prevent inventory compilers from using verified emissions reported under the ETS directly for emission reporting in the national GHG inventory. Quelle: https://www.umweltbundesamt.de
Improvising Knowledge: A Case Study of Practices in and Around World Spine Care's Evidence-based Clinics in Shoshong and Mahalapye, Botswana
Creators: name: Mongeon, Mylène
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Global Health
Non-governemental organization
Humanitarian Medicine
World Spine Care
Medical Anthropology
Botswana
Shoshong
Mahalapye
Chiropractic
Physiotherapy
Evidence-based Medicine
Craft
Phenomenology
Creativity
Improvisation
Traditional doctors
Cultural adaptation
Interprofessional collaboration
Skills

description: Global health organizations attend to populations around the world applying an evidence-based model of care that often does not correspond with local realities on the ground. My thesis provides an in-depth anthropological study of how this occurs within practices in and around World Spine Care's (WSC) clinics in Shoshong and Mahalapye, Botswana. More specifically I explore how knowledge is negotiated and improvised on the ground, paying particular attention to the ways WSC volunteers are (un)able to work with local health workers as they desire. I show the flows and counter-flows implicated in the difficult task of reconciling skills with standards. The study is based on a total of 15 months of participation with WSC's organization through attending meetings, activities and shadowing practitioners both in Ottawa and in Botswana. Expanding the scope of their creative improvisational skills beyond the closed settings of WSC clinics is proposed as a way to move forward.
Supplementary document for Increase in terahertz-wave generation by difference frequency mixing by overlap of exciton states in different GaAs/AlAs quantum wells and spectroscopic measurements - 5331472.pdf
Creators: name: Kojima, Osamu
name: Sakaue, Kanta
name: Kita, Takashi
name: Steer, Matthew
name: Hogg, Richard
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Uncategorized

description: FigsS1-S3
Deaf1 and MeCP2 Interact to Coordinately Regulate 5-HT1A Receptor Gene Expression
Creators: name: Philippe, Tristan
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Depression
genetics
epigenetics
molecular
neuroscience

description: Deaf1 regulates 5-HT1A receptor gene (HTR1A) transcription by binding a 26-bp palindromic DNA sequence containing the rs6295 C(-1019) HTR1A polymorphism. However, Deaf1 cannot bind the G(-1019) HTR1A allele, which is associated with major depression. MeCP2 is impli-cated in serotonergic regulation and because the C(-1019) is a methylation site, I addressed whether MeCP2 alters Deaf1 regulation of HTR1A. MeCP2 and Deaf1 co-precipitated and bound the putative Deaf1 sites of the mouse HTR1A promoter in vivo. Binding of MeCP2 to the Deaf1 site was dependent on Deaf1 and MeCP2 increased Deaf1 recruitment to its site independ-ently of methylation. MeCP2, Deaf1 and their combination modulated transcription of human and mouse HTR1A luciferase reporter constructs, with Deaf1 having a dominant effect, Deaf1 actions were disrupted by mutation of the Deaf1 site(s). Deaf1 KO or MeCP2 cKO in mice in-creased functional 5-HT1A autoreceptor-mediated hypothermia response. Overall, MeCP2 and Deaf1 coordinately regulate the HTR1A promoter.
Interview with Graeme Hugo
Creators: name: Mares, Peter
name: Hugo, Graeme
Publisher: name: Swinburne
Year: 2024

description: Graeme Hugo is Federation Fellow, Professor of the Discipline of Geographical and Environmental Studies and Director of the National Centre for Social Applications of Geographical Information Systems at the University of Adelaide. He is the author of over 200 books, articles in scholarly journals and chapters in books, as well as a large number of conference papers and reports.
Amplification of Long-Range Surface Plasmon-Polaritons
Creators: name: De Leon Arizpe, Israel
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: Surface plasmon-polaritons
Optical amplification
Amplified spontaneous emission
Stimulated emission
Optical waveguides

description: Surface plasmon-polaritons are optical surface waves formed through the interaction of photons with free electrons at the surface of metals. They offer interesting applications in a broad range of scientific fields such as physics, chemistry, biology, and material science. However, many of such applications face limitations imposed by the high propagation losses of these waves at visible and near-infrared wavelengths, which result mainly from power dissipation in the metal. In principle, the propagation losses of surface plasmon-polaritons can be compensated through optical amplification. The objective of this thesis is to provide deeper insights on the physics of surface plasmon-polariton amplification and spontaneous emission in surface plasmon-polariton amplifiers through theoretical and experimental vehicles applied (but not necessarily restricted) to a particular plasmonic mode termed long-range surface plasmon-polariton. On the theoretical side, the objective is approached by developing a realistic theoretical model to describe the small-signal amplification of surface plasmon-polaritons in planar structures incorporating dipolar gain media such as organic dye molecules, rare-earth ions, and quantum dots. This model takes into account the inhomogeneous gain distribution formed near the metal surface due to a non-uniform excitation of dipoles and due to a position-dependent excited-state dipole lifetime that results from near-field interactions between the excited dipoles and the metal. Also, a theoretical model to describe the amplified spontaneous emission of surface plasmon-polaritons supported by planar metallic structures is developed. This model takes into account the different energy decay channels into which an exited dipole located in the vicinity of the metal can relax. The validity of this model is confirmed through experimentation. On the experimental side, the objective is approached by providing a direct experimental demonstration of complete loss compensation in a plasmonic waveguide. The experiments are conducted using the long-range surface plasmon-polariton supported by a symmetric thin gold waveguide incorporating optically pumped organic dye molecules in solution as the gain medium. Also, an experimental study of spontaneous emission in a long-range surface plasmon-polariton amplifier is presented. It is shown that this amplifier benefits from a low spontaneous emission into the amplified mode, which leads to an optical amplifier with low noise characteristics. The experimental setup and techniques are explained in detail.
Supplementary document for High-efficiency generation of narrow-band soft x-rays from carbon nanotube foams irradiated by relativistic femtosecond lasers - 5332485.pdf
Creators: name: Shou, Yinren
name: Wang, Dahui
name: WANG, PENGJIE
name: Liu, Jianbo
name: Cao, Zhengxuan
name: Mei, Zhusong
name: Xu, Shirui
name: Pan, Zhuo
name: Kong, Defeng
name: Qi, Guijun
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement 1
A role for CRH and HPA Activation in the Regulation of Plasticity Signaling, Neuroinflammation and Emotional/Mnesic Behavior Following Global Cerebral Ischemia in Rats
Creators: name: Barra De La Tremblaye, Patricia
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Global cerebral ischemia
Corticotropin releasing hormone
BDNF/TrkB
HPA dysregulation
Anxiety
Depression
Sociability
Learning & Memory
Neuroprotection
Neuroinflammation

description: Depression occurs in about one third of patients with stroke and cardiac arrest. Hyperactivity of the stress system is the most commonly observed neuroendocrine change in major depressive disorder (MDD), which involves elevated levels in the cerebrospinal fluid of corticotropin-releasing hormone (CRH), a key stress neurohormone. Substantial evidence suggests that normalization of the stress system may be a requirement for successful treatment of MDD through region-specific changes in the mesocorticolimbic circuitry. Thus, alteration in the stress system may underlie the emotional and functional impairments observed following brain ischemic events. In addition, recent findings suggest that ischemic brain injury triggers a restorative process, creating a cerebral environment similar to that of early brain development, a period characterized by rapid neuronal growth and neuroplasticity, critical to optimize functional recovery of individuals post stroke. In particular brain-derived neurotrophic factor (BDNF), has been shown to play an important role in the pathophysiology of major depression and cerebral ischemia. However, whether CRH can mediate the expression of BDNF in the reparative process triggered by ischemic injury remains to be characterized. Therefore, the purpose of the current thesis is to characterize the effect of pharmacological blockade of CRH signaling at the onset of a global ischemic stroke, on emotional and cognitive behaviors, alteration in the neuroendocrine stress system, and markers of neuroplasticity including BDNF. To do this, an animal model of global cerebral ischemia with subsequent behavioral testing and postmortem brain analysis was used to determine underlying biochemical and behavioral changes modulated by CRH signaling following brain ischemia. This doctoral work will help elucidate the relationship between CRH and BDNF in the context of cerebral ischemia, and may provide insights for therapies targeting the stress system. These studies address considerations such as: the interplay between stress, neuroplasticity and emotionality, and whether global ischemia can affect mood via changes in the HPA axis response.
Maßnahmen zur Verbesserung der Marktdurchdringung klimafreundlicher Technologien ohne halogenierte Stoffe vor dem Hintergrund der Revision der Verordnung (EG) Nr. 842/2006
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015
Subjects: subject: F-Gase
subject: Europäische F-Gase-Verordnung
subject: Klimafreundliche Technologie
subject: Fluorierte Treibhausgase
subject: F-Gase-Verordnung
subject: Höchstmengenbegrenzung
subject: Klima | Energie
subject: Climate | Energy

description: Die Emissionen fluorierter Treibhausgase (HFKW, FKW, SF6) konnten durch die Verordnung (EG) Nr. 842/2006 stabilisiert werden. Für eine darüber hinaus angestrebte Reduzierung war eine Überarbeitung der Verordnung erforderlich, die in den Jahren 2012 bis 2014 erfolgte. Eine Neufassung wurde im April 2014 verabschiedet (Verordnung (EU) Nr. 517/2014). Dieses Vorhaben hat die Arbeit des Umweltbundesamtes während des Überarbeitungsprozesses unterstützt. Mittels Literaturauswertung identifizierte Barrieren und Chancen für halogenfreie Stoffe und/oder Technologien in verschiedenen Anwendungen sind in Übersichtstabellen aufgelistet und in ihrer Relevanz bewertet.
Quelle: https://www.umweltbundesamt.de/
description: Die Emissionen fluorierter Treibhausgase (HFKW, FKW, SF6) konnten durch die Verordnung (EG) Nr. 842/2006 stabilisiert werden. Für eine darüber hinaus angestrebte Reduzierung war eine Überarbeitung der Verordnung erforderlich, die in den Jahren 2012 bis 2014 erfolgte. Eine Neufassung wurde im April 2014 verabschiedet (Verordnung (EU) Nr. 517/2014). Dieses Vorhaben hat die Arbeit des Umweltbundesamtes während des Überarbeitungsprozesses unterstützt. Mittels Literaturauswertung identifizierte Barrieren und Chancen für halogenfreie Stoffe und/oder Technologien in verschiedenen Anwendungen sind in Übersichtstabellen aufgelistet und in ihrer Relevanz bewertet.
Qualité physico-chimique et biologique de l’oued Ouislane au sein de la ville de Meknes (Centre nord du Maroc)
Creators: name: Addouli, Jamal El
name: Chahlaoui Abdelkader
name: Berrahou, Ali
name: Abdelhafid Chafi
name: Ennabili, Abdeslam
Publisher: name: figshare
Year: 2020
Subjects: Environmental Science

description: Physicochemical and biological qualities of Ouislane wadi in Meknès city. The superficial water system draining Meknès city includes Ouislane wadi. In order to characterize quality of this river, a study of physicochemical and biological parameters has been carried out. The obtained results underline a worst quality of this river which is menaced particularly by human activities.
SLK-mediated Phosphorylation of Paxillin Is Required for Focal Adhesion Turnover and Cell Migration
Creators: name: Jennifer Leigh, Quizi
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: SLK
Paxillin
Phosphorylation
Focal adhesion turnover
Cell migration

description: The precise mechanism regulating focal adhesion disassembly has yet to be elucidated. Recently, we have implicated the Ste20-like kinase SLK in mediating efficient focal adhesion turnover and cell migration in a Rac-1 and FAK-dependent manner. Although an indirect association of this kinase with the microtubule network has been determined, the exact involvement of SLK in the disassembly of the adhesion complex remains unclear. With the identification of the focal adhesion protein paxillin as a substrate of SLK, we show that SLK regulates adhesion turnover through its phosphorylation at S250. Mutation of S250 to a threonine residue ablates SLK phosphorylation of paxillin in vitro and results in reduced adhesion turnover and migration in vivo. Additionally, our studies demonstrate that overexpression of the paxillin S250T mutation prevents the redistribution of paxillin to the membrane ruffle in migrating cells. The complete loss of polyubiquitylation in the S250T mutant, combined with no observed reduction in S250T protein expression, suggests that S250 phosphorylation is required for a ubiquitin-mediated modification that regulates paxillin redistribution within the cell. Moreover, we show that phosphorylation of S250 is required for paxillin to interact with FAK. An observed accumulation of phospho-FAKY397 in cells overexpressing the paxillin S250T mutant suggests that phosphorylation of S250 is involved in regulating FAK-dependent focal adhesion dynamics. Consequently, our data suggests that SLK regulates adhesion turnover through the phosphorylation of paxillin at S250.
Book review: 'Singing with colour' by Glen Phillips
Creators: name: Hecq, Dominique
Publisher: name: Swinburne
Year: 2024

description: Review of the book 'Shanghai Suite and Other Poems', by Glen Phillips, published by ICLL, Edith Cowan University, Mount Lawley, WA, 2009 and the book 'Singing Granites: Poems of Devon and Gondwanaland', by Anne Born and Glen Phillips, published by Oversteps Books, Nr Kingsbridge UK, 2008.
Supplementary document for High-efficiency generation of narrow-band soft x-rays from carbon nanotube foams irradiated by relativistic femtosecond lasers - 5332485.pdf
Creators: name: Shou, Yinren
name: Wang, Dahui
name: WANG, PENGJIE
name: Liu, Jianbo
name: Cao, Zhengxuan
name: Mei, Zhusong
name: Xu, Shirui
name: Pan, Zhuo
name: Kong, Defeng
name: Qi, Guijun
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Uncategorized

description: Supplement 1
Male Students’ Experiences in Urban High School Physical Education in Makkah, Saudi Arabia
Creators: name: Majed, Alharbi
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: saudi boys' experiences
habitus
physical education
physical capital

description: This study explores male students’ experiences in physical education in an urban secondary high school in Makkah, Saudi Arabia. Drawing on Pierre Bourdieu’s concepts of body habitus, social, and physical capital, the purpose of this qualitative case study is to develop a better understanding of Saudi youth body dispositions that influence their experiences in physical education. The paper reports upon data generated by semi-structured interviews with 27 male students between the ages of 15 and 20, all of whom attended one public secondary school in Makkah during the fall of 2012. The PE teacher and the school director were also interviewed. The study emphasizes that the early childhood experiences in particular the socialization process within the family and among neighbourhood friends is important in shaping their body habitus. The study reveals that students coming to the PE class embodied different social practices and attitudes that reflect their family’s social and material conditions. In addition, family and peers influences on students’ PE participation intersected with other conditions such as institutional barriers (i.e. lack of funding, PE equipment, changing and showering rooms) and the PE teacher’s pedagogical approach. The study indicates that the more initial support students receive from their social networks in physical activity, the more they actively participate in the PE class. Students with high physical body skills have a high level of participation in PE while those with low physical body skills have a low level of participation, some then being marginalized. Hygiene is another issue that concerns some students in ways that prevents them from participation in PE. Surprisingly, the Saudi adult masculine identity associated with traditional clothing (thawb) is also a condition that influences student PE participation.
A Quality Guaranteed Video Dissemination Protocol over Urban Vehicular Ad Hoc Networks
Creators: name: Li, Yang
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Vehicular Ad Hoc Networks
Video Dissemination
Urban Scenario

description: Video dissemination over Vehicular Ad Hoc Networks (VANETs) is an attractive technology which supports many novel applications. Hence, the merit of this thesis has twofold. Firstly, we evaluate and compare three routing techniques and two error resilience techniques. We select a sender-based routing technique called SUV and compare it with the other two selected receiver-based routing techniques named REACT-DIS and CDS. The results, more specifically, show that the receiver-based solutions outperform the sender-based solution. In addition, only CDS method fulfils the general quality requirements as it is the best that reduces redundancy packets and covers the whole topology. The results also indicate that the video coding scheme, Interleaving, can fix the multiple consecutive packet losses and guarantee reliable video qualities over VANETs. Network Coding, however, fails to provide satisfactory video quality for urban scenarios. This study next combines the selected receiver based routing techniques and the two error resilience techniques. We find the best combination is Interleaving over CDS. Secondly, we design a quality guaranteed video dissemination protocol for urban VANETs scenarios. Based on our comparison result, our protocol selects the CDS and Interleaving as the routing and error resilient techniques. To fix the single packet loses caused by the topology’s intermittent disconnection and collisions, we propose a store-carry-broadcast scheme for the nodes to re-transmit the local buffer saved packets. The results, when compared to the selected techniques and combinations, show that our proposed protocol is the most efficient one in terms of packet delivery, delay, overhead and video quality.
Tourniquet-induced nerve compression injuries are caused by high pressure levels and gradients – a review of the evidence to guide safe surgical, pre-hospital and blood flow restriction usage
Creators: name: Masri, Bassam A.
name: Eisen, Andrew, 1936-
name: Duncan, Clive P.
name: McEwen, James A.
Publisher: name: BioMed Central
Year: 2020

description: Tourniquets in orthopaedic surgery safely provide blood free surgical fields, but their use is not without risk. Tourniquets can result in temporary or permanent injury to underlying nerves, muscles, blood vessels and soft tissues. Advances in safety, accuracy and reliability of surgical tourniquet systems have reduced nerve-related injuries by reducing pressure levels and pressure gradients, but that may have resulted in reduced awareness of potential injury mechanisms. Short-term use of pre-hospital tourniquets is effective in preventing life-threatening blood loss, but a better understanding of the differences between tourniquets designed for pre-hospital vs surgical use will provide a framework around which to develop guidelines for admitting to hospital individuals with pre-applied tourniquets. Recent evidence supports the application of tourniquets for blood flow restriction (BFR) therapy to reduce muscular atrophy, increase muscle strength, and stimulate bone growth. BFR therapy when appropriately prescribed can augment a surgeon’s treatment plan, improving patient outcomes and reducing recovery time. Key risks, hazards, and mechanisms of injury for surgical, BFR therapy, and pre-hospital tourniquet use are identified, and a description is given of how advances in personalized tourniquet systems have reduced tourniquet-related injuries in these broader settings, increasing patient safety and how these advances are improving treatment outcomes.
Supplementary document for Comprehensive characterization of terahertz generation with the organic crystal BNA - 5332533.pdf
Creators: name: Tangen, Isaac
name: Valdivia-Berroeta, Gabriel
name: Heki, Larry
name: Zaccardi, Zachary
name: Jackson, Erika
name: Bahr, Charles
name: Michaelis, David
name: Johnson, Jeremy
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Information on detection bandwidth, THz spectra comparison, Lorentz oscillator fit results, and x-ray structure details
Consideration for Rare Diseases in the Context of Drug Reimbursement Processes
Creators: name: Gosain, Sheena
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015

description: The aims of this thesis were to identify whether justification can be provided for the specialized consideration of drugs for rare diseases (DRDs) within reimbursement decision-making, to understand the processes applied for making coverage decisions for DRDs, and to identify how funding outcomes may differ based on the evaluation process used. The characteristics of DRDs were considered in the frame of developing an ethically acceptable rationale for the differential consideration of DRDs within coverage decision-making. The results revealed that the differing evidence base might provide ethical justification for a specialized process, but this does not justify the use of differential funding criteria. A review of processes applied internationally and within Canadian provinces and territories demonstrated that 13 out of 59 processes consider DRDs distinctively. Finally, two case studies of DRDs, Alglucosidase alfa and Canakinumab, were considered to provide insight into the application of different drug reimbursement processes and associated funding outcomes. The results highlight the heterogeneity in funding outcomes for DRDs, which arises through the application of different funding outcomes. While currently processes exist for the evaluation of DRDs and drugs in general, limitations exist with current approaches. Processes should aim to be fair and jurisdictions should carefully consider the justification underpinning a dedicated process for DRDs.
Meta-Modelling to Quantify Yields of White Spruce and Hybrid Spruce Provenances in the Canadian Boreal Forest
Creators: name: Ahmed, Suborna
name: LeMay, Valerie
name: Yanchuk, Alvin
name: Robinson, Andrew
name: Marshall, Peter Lawrence, 1953-
name: Bull, Gary
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2020

description: Tree improvement programs can improve forest management by increasing timber yields in some areas, thereby facilitating conservation of other forest lands. In this study, we used a meta-analytic approach to quantify yields of alternative white (Picea glauca (Moench) Voss) and hybrid spruce (Picea engelmannii Parry ex Engelmann x Picea glauca (Moench) Voss) stocks across planting sites in the boreal and hemiboreal forests of Canada. We extracted meta-data from published tree improvement program results for five Canadian provinces covering 38 planting sites and 330 white and hybrid spruce provenances. Using these meta-data and a random-coefficients nonlinear mixed-effects modelling approach, we modelled average height over time trajectories for varying planting site characteristics, as well as climate transfer distances between planting sites and provenances. Climatic transfer distances had strong effects on the height trajectory parameters. In particular, the asymptote parameter had a nonlinear increasing trend with planting site versus provenance mean annual temperature differences. We incorporated the height trajectory meta-analysis model into an existing growth and yield model to predict volume yields. Overall, this research provides a mechanism to quantify yields of alternative provenances at a particular planting site, as a component of decision support models for evaluating evaluate forest management investment into improved planting stocks alternatives under current and possible future climates.
Who's on the line? Policing and enforcing laws relating to mobile phone use while driving
Creators: name: Jessop, Glenn
Publisher: name: Swinburne
Year: 2024

description: This article investigates how laws relating to mobile phone use in cars are written, interpreted and applied in real life. It explores how regulations are imposed, the difficulties that are encountered in terms of enforcement, and how laws have been policed and tested in court. By focusing on the socio-legal context in Victoria and drawing upon international comparisons, we see that stories of enforcement highlight the unique and particular questions asked of existing legal systems by motorists using a mobile phone. Moreover, in describing the problematic process of developing and implementing legal regulations, we see that road rules are struggling to adapt to a transitional technology and that there are significant obstacles to enforcing the laws.