cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Ligand preferences in ytterbium ions complexation with carboxylate-based metal-organic frameworks
Creators: name: Alireza Hashemzadeh
name: Amini, Mostafa M.
name: Khavasi, Hamid Reza
name: Seik Weng Ng
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Plant Biology
subject: FOS: Biological sciences

description: Two coordination polymers of ytterbium were synthesized by employing 4,4′,4″-s-triazine-2,4,6-triyl-tribenzoic acid (H3TATB), 4,4′,4-benzene-1,3,5-triyl-tribenzoic acid (H3BTB), and 3,5-pyridinedicarboxylic acid (3,5-PDC) ligands and were characterized by single-crystal X-ray diffraction analysis. Reaction of ytterbium(III) chloride in the presence of H3BTB and 3,5-PDC ligands gives preferred complexation with the 3,5-PDC ligand, producing [Yb2(3,5-PDC)(ClO4)3][NH(Me)3] (1). However, under exactly the same reaction conditions, reaction of ytterbium(III) chloride in the presence of 3,5-PDC and H3TATB resulted in complexation with H3TATB to form [(CH3)2NH2][Yb4(TATB)4(HCO2)(H2O)2]·3H2O (2). The crystal structure results showed a layered structure for 1 and a metal-organic framework structure for 2. This indicates that the complexation preference of the ytterbium ion is H3TATB ≥ 3,5-PDC ≥ H3BTB. Conversely, the uncomplexed ligand in the metal-organic framework (2) is an auxiliary agent during the synthesis, which shows polytopic linker controls crystal properties, to form suitable crystals for single-crystal structure determination. The prepared coordination compounds were used as heterogeneous catalysts in an oxidation amidation reaction with different aldehydes and benzylamine hydrochloride.
Identifikasi jejak dan tanda-tanda keberadaan berang-berang (Lutrinae) di area persawahan kecamatan Lubuk Alung Kabupaten Padang Pariaman
Creators: name: Aadrean, Aadrean
Publisher: name: figshare
Year: 2017
Subjects: subject: 60809 Vertebrate Biology
subject: FOS: Biological sciences

description: Skripsi Jurusan Biologi Universitas Andalas
Additional file 2 of Integrative multi-omics analysis reveals novel idiopathic pulmonary fibrosis endotypes associated with disease progression
Creators: name: Ruan, Peifeng
name: Todd, Jamie L
name: Zhao, Hongyu
name: Liu, Yi
name: Vinisko, Richard
name: Soellner, Julia F.
name: Schmid, Ramona
name: Kaner, Robert J.
name: Luckhardt, Tracy R.
name: Neely, Megan L.
name: Noth, Imre
name: Porteous, Mary
name: Raj, Rishi
name: Safdar, Zeenat
name: Strek, Mary E
name: Hesslinger, Christian
name: Palmer, Scott M.
name: Leonard, Thomas B.
name: Salisbury, Margaret L.
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: Virology
subject: Computational Biology

description: Additional file 2: Table S1. Number of toRNA, miRNA and proteomics features available for modeling after filtering and pre-processing.
Deep Work – zur Relevanz eines «wiederentdeckten» Arbeitsmodus für die Gestaltung von Arbeit und Büroräumen
Creators: name: Schulze, Hartmut
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2018
Subjects: subject: Arbeitspsychologie
subject: Büroraumgestaltung
subject: Deep Work
subject: 100

description: Die Verbindung von Coworking und Deep Work ist bei der Gestaltung von Bürolandschaften eine Herausforderung. Bisherige Coworking Spaces zeichnen sich ja vor allem durch ein vielfältiges Angebot an Kollaborationsflächen aus. Nebeneinander aber nicht allein, dies ist in diesem Zusammenhang ein wichtiges Motto. Manchmal und für manche ist das Für-sich-Arbeiten in einem bevölkerten Café ertragreicher als im einsamen Home Office. Gleichzeitig kommt aber dem Angebot von Räumlichkeiten für zurückgezogene Einzel- oder Gruppenarbeit und deren einfacher Zugänglichkeit am besten in Sichtweite von Standardarbeitsplätzen eine wichtige Bedeutung für die Zufriedenheit mit der Arbeitsumgebung, für das Wohlbefinden und die Leistungsfähigkeit zu. So gesehen ist das Nebeneinander von gut ausgestatteten und gut gestalteten Rückzugsräumen und von Räumlichkeiten für Zusammenarbeit und Kollaboration perspektivisch richtig. Zentral dafür ist sicherlich die Realisierung einer adaptiven Akustik. Eine zu hohe Lärmbelastung durch Gespräche, Telefonate und Bewegung stellt noch immer eine der zentralen Schwachstellen bestehender Grossraumbüros und Multispaces dar.
title: Unter dem Radar – Herausforderung in Diagnostik und Therapie des nested type Urothelkarzinoms
Creators: name: Schröter, F.
name: Hanschmann, U.
name: Puchtler, G.
name: Haas, V.
name: Wöhr, M.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Das nested type Urothelkarzinom (UC) der Blase ist eine seltene Sonderform des UC, dessen Besonderheit sich im meist submucösem Wachstum auszeichnet. Dies führt oft zu einer verspäteten Diagnostik mit konsekutiv hohem Anteil von muskelinvasiven oder weiter fortgeschrittenen Karzinomen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
title: Onkologische Langzeitergebnisse nach primärer HIFU-Ganzdrüsentherapie beim lokalisierten Prostatakarzinom aus einem Einzelzentrum mit 21 Jahren Follow-up
Creators: name: Rosenhammer, B.
name: Osberghaus, V.
name: Zeman, F.
name: Breyer, J.
name: Denzinger, S.
name: Burger, M.
name: Bründl, J.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Bereits seit vielen Jahren wird die Therapie mittels HIFU (high-intensity focused ultrasound) als minimal-invasive Behandlungsalternative beim lokalisierten Prostatakarzinom eingesetzt. Während zuletzt fokale Therapiestrategien in den Vordergrund traten, stehen für die Ganzdrüsen-HIFU-Behandlung[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
Additional file 5 of Integrative multi-omics analysis reveals novel idiopathic pulmonary fibrosis endotypes associated with disease progression
Creators: name: Ruan, Peifeng
name: Todd, Jamie L
name: Zhao, Hongyu
name: Liu, Yi
name: Vinisko, Richard
name: Soellner, Julia F.
name: Schmid, Ramona
name: Kaner, Robert J.
name: Luckhardt, Tracy R.
name: Neely, Megan L.
name: Noth, Imre
name: Porteous, Mary
name: Raj, Rishi
name: Safdar, Zeenat
name: Strek, Mary E
name: Hesslinger, Christian
name: Palmer, Scott M.
name: Leonard, Thomas B.
name: Salisbury, Margaret L.
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: Virology
subject: Computational Biology

description: Additional file 5: Figure S2. Average Silhouette scores of consensus clustering for 2 to 10 clusters. Section S4. Multi-omics clustering by different methods. Table S2. Cluster membership consensus between scSNF and iClusterPlus or iClusterBayes. Table S3. Sensitivity analysis based on different variance filters for RNA-seq data. Table S4. Comparison of molecular subtypes based on scSNF with high-risk and low-risk groups based on the 52-gene signature. Table S5. Agreement (based on Normalized Mutual Information [NMI]) in distribution of subjects to molecular subtypes using a single molecule type compared to distribution using the scSNF fused multi-omics dataset. Table S6. Differentially abundant proteins by molecular subtype. Table S7. Differentially expressed miRNAs by molecular subtype.
In Vivo Monitoring of Liposomal Encapsulated siRNA Delivery
Creators: name: Kenny, Gavin David
Publisher: name: Imperial College London
Year: 2010

description: RNA interference (RNAi) is being widely explored as a means of tumour therapy due to the specific and potent silencing of targeted genes. However, in vivo delivery of RNAi effectors, such as small interfering RNA (siRNA) and detection of delivery is fraught with problems. In this thesis a novel theranostic PEGylated siRNA nanoparticle, termed liposome encapsulated siRNA (LEsiRNA) was developed and tested in vitro and in vivo. The LEsiRNA nanoparticles were formulated to be MR sensitive and contain labels for fluorescence microscopy/histology. The nanoparticles were shown to be an ideal size for in vivo delivery, under 100 nm, stable over 4 days and have a MR relaxivity better than the clinically used contrast agent Dotarem. The LEsiRNA nanoparticles were tested in vitro to assess their suitability for use in vivo. It was found that incubation of the particles with cells led to a decrease in protein level of the targeted cancer gene, Survivin, an inhibitor of apoptosis. In vivo assessment of the LEsiRNA nanoparticles demonstrated their potential as a theranostic agent, delivering therapy, while simultaneously allowing monitoring of tumour delivery. The LEsiRNA nanoparticles, administered by intravenous injection, were shown to accumulate in xenograft tumours by MRI at 16 and 24 hours post administration. Fluorescence microscopy of ex vivo tumour samples was used to corroborate the MR results and simultaneously demonstrate co-localisation of nanoparticles and siRNA within the tumours. The LEsiRNA nanoparticle-mediated delivery of the anti-cancer Survivin siRNA caused a significant reduction in both Survivin expression and tumour growth when compared to controls. These results suggest that LEsiRNA nanoparticles can be valuable as an in vivo delivery agent for siRNA therapy to tumours. As a way to non-invasively assess the tumour therapy effect caused by the Survivin LEsiRNA nanoparticles, an MR contrast agent targeted to apoptotic cells was investigated. This agent was tested in vitro and found, by MRI, to selectively bind to apoptotic cells. This suggests that the agent could be used in vivo to give an early prognosis, after a therapeutic intervention, without the need for an invasive biopsy. The favourable biodistribution of the LEsiRNA nanoparticles to tumours and the subsequent successful functional delivery of Survivin siRNA, with simultaneous monitoring by MRI, suggests that these LEsiRNA nanoparticles have real potential for the future treatment of cancer. The ability to non-invasively detect the effect of the LEsiRNA nanoparticles on tumours in vivo, afforded by the apoptotic targeted contrast agent, is also paramount for future clinical applications. Therefore, these two agents have great potential in the treatment and prognosis of cancer.
Role of Endogenous Glutathione-S-Transferases in Lung Cell Survival and Inflammation
Creators: name: Fletcher, Marianne Ellen
Publisher: name: Imperial College London
Year: 2011

description: Background: Glutathione-S-Transferase (GST) family of enzymes serve as a key antioxidant system. Clinical evidence suggests that several GST polymorphisms are associated with inflammatory lung diseases. The mechanisms by which these polymorphisms impact on cellular responses to stress remain unknown. To define the specific role of GST isoenzymes, we investigated the influence of GST inhibition on lung cell survival and inflammation, in in vitro and ex vivo models. Methodology: Pulmonary cells were exposed to GST inhibitors ethacrynic acid or caffeic acid alone, or in combination with oxidative stressors hydrogen peroxide, tert-butyl-hydroperoxide or hypoxia and reoxygenation. RNA interference was employed to attenuate specific GST isoform activity. Cell injury was assessed by MTT assay and flow cytometry. Oxidative stress was investigated by: (a) DHR123 and DCF fluorescence, (b) monitoring intracellular redox state by HPLC, (c) measurement of protein carbonyls by spectrophotometry and d) evaluation of the effects of specific and broad-spectrum antioxidants. Mitochondrial energetics was assessed by calculation of ATP/ADP ratios by HPLC, while global metabolic response was evaluated by NMR spectroscopy. An ex vivo mouse isolated perfused lung (IPL) model was used to explore the physiological role of GST. Principal findings: Two GST inhibitors and genetic attenuation of GSTπ significantly increased oxidative stress and induced cytotoxicity of lung epithelial cells and rendered them more susceptible to oxidative stress. While cellular energy state was not compromised, EA potentiated protein carbonylation and caused metabolic derangements. Furthermore, in the ex vivo model, EA significantly increased pulmonary permeability and intra-alveolar oedema, which may have been responsible for the increase in pulmonary elastance and resistance that were also observed. Conclusion: These observations highlight the importance of GST enzymes, specifically GSTπ, in the cellular and whole lung response to stress conditions and may help to understand the metabolic determinants of oxidative lung injury and adaptation.
The role of endogenous free radical signalling in human endometrium
Creators: name: Al Sabbagh, Marwa Khalid Ebrahim Ali
Publisher: name: Imperial College London
Year: 2011

description: Differentiation of human endometrial stromal cells (HESCs) into specialized decidual cells is critical for embryo implantation and maintenance of a successful pregnancy. Initiation of this differentiation process, termed decidualization, is strictly dependent on elevated cAMP levels, whereas its maintenance requires continuous progesterone signalling. Here I show that NADPH oxidase-dependent reactive oxygen species (ROS) play a critical role in initiating and maintaining the decidual process. I first show that cAMP-dependent induction of decidual marker genes can be attenuated or enhanced upon inhibition or activation of the NADPH oxidase complex, respectively. Time-course analysis demonstrated that cAMP enhances endogenous ROS production, apparent after 12 hours of stimulation, which coincides with a marked induction of differentiation markers. By a process of elimination, I identified NOX4 as the main catalytic subunit involved in decidualization. Silencing of NOX4, or its cofactor p22PHOX, impaired the decidual process. I then show that the NOX4/p22PHOX complex regulates the transcriptional activity of CCAAT/enhancer binding protein β, a key regulator of HESC differentiation. Furthermore, microarray analysis revealed that the NOX4/p22PHOX complex functions downstream FOXO1, a multifaceted transcription factor involved in antioxidant defences, DNA repair and cell cycle regulation. In agreement, knockdown of NOX4/p22PHOX complex disrupted endogenous ROS production and resulted in a paradoxical prooxidant stress response further characterized by activation of the DNA repair pathway in the absence of primary DNA damage or cell death. Finally, I provide preliminary data that p22PHOX is downregulated at the transcript and protein level in the eutopic endometrium of patients with endometriosis. In summary, endogenous ROS signalling is critical for the differentiation and redox homeostasis of HESCs. Furthermore, deregulation of endometrial NADPH oxidase-dependent ROS production and signalling may be a hallmark of endometriosis, a prevalent and debilitating reproductive disorder.
Additional file 1: of Zigzag Hollow Cracks of Silver Nanoparticle Film Regulated by Its Drying Micro-environment
Creators: name: Tao, Ruiqiang
name: Zhang, Jianhua
name: Fang, Zhiqiang
name: Ning, Honglong
name: Chen, Jianqiu
name: Yang, Caigui
name: Zhou, Yicong
name: Yao, Rihui
name: Song, Yongsheng
name: Peng, Junbiao
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Figure S1. Monodispersed nanoparticles obtained after UV irradiation for 60 s. Figure S2. Schematic of asymmetrical directional flows of two neighboring droplets. Figure S3. High-quality nanoparticle film optimized with enhanced chemical reduction. (a) Schematic of wet film cured with different distance (8 cm, 24 cm) from the UV lamp. The side wall of the curing box is specially designed to achieve uniform UV irradiation, whose strength can be significantly increased when a closer distance from the UV lamp is applied (E1<
title: Outcome der externen Radiotherapie nach primärer HIFU Ablation der Prostata beim lokal begrenzten Prostatakarzinom
Creators: name: Cafuta, B.
name: Distler, F.
name: Albrecht, C.
name: Pahernik, S.
name: Hüttenbrink, C.
name: Hatiboglu, G.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Die „Hochintensive Fokussierte Ultraschall“-Therapie (HIFU) als minimal invasive Behandlungsmethode zählt zu den alternativen Behandlungsmethoden des lokal begrenzten Prostatakarzinoms. Zur Therapie eines Lokalrezidivs nach stattgefundener HIFU Therapie gibt es derzeit kaum Daten[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
Non-interlayer hybrid white organic light-emitting diodes via a bipolar mixed host for the blue-fluorescent-emitting layer
Creators: name: Yongwon Kwon
name: Changhee Lee
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology

description: The reduction of the interlayer in hybrid white organic light-emitting diodes (WOLEDs) provides a potential for improving the device efficiency. Reported herein are non-interlayer hybrid WOLEDs prepared using a mixed host for the blue-fluorescent-emitting layer. The proposed device exhibits high efficiency with the maximum external quantum efficiency up to 17.1%, and stable colors. Moreover, the effect of the interlayer on the device lifetime was demonstrated.
The Role of Endovenous Thermal Ablation in the Treatment of Varicose Veins
Creators: name: Shepherd, Amanda Claire
Publisher: name: Imperial College London
Year: 2010

description: Varicose veins are a common problem affecting approximately 30% of the Western population. The majority of patients present to secondary care complaining of a number of commonly experienced symptoms, however, some present with severe complications of venous disease including venous ulceration. For hundreds of years varicose veins have been treated with compression and surgery. In the last decade, technological advances have lead to the introduction of minimally invasive therapies for varicose veins, with the aim of providing rapid treatment with minimum discomfort to the patient at acceptable cost to the healthcare provider. This study examined the current use of endovenous ablation procedures in the United Kingdom amongst consultant vascular surgeons using an online questionnaire and also explored the patient’s views regarding treatment of varicose veins and potential therapeutic options. Prior to conducting a randomised clinical trial comparing early outcomes following laser and radiofrequency ablation in patients with primary varicose veins, an observational pilot study was carried out in the department. In parallel, the use of disease specific quality of life tools were compared to clinical, anatomical and haemodynamic outcome measures in this cohort of patients. The findings of the study have shown that although endovenous ablation procedures appear to be increasing in popularity, traditional surgery remains the most frequently performed procedure. Overall, patients overall have little knowledge of potential treatment options and the majority would be in favour of a single treatment under a local anaesthetic. However, most would be strongly influenced by the advice and opinion of the surgeon to whom they were referred. Results from the pilot study and a randomised clinical trial showed that radiofrequency ablation is significantly less painful than laser ablation for up to 10 days post procedure. Clinical improvements and gains in quality of life were significantly improved at 6 weeks and 6 months post intervention compared with baseline scores and were comparable between the groups. No significant difference was observed in anatomical outcomes between the two treatments. Although radiofrequency may be less painful than laser ablation, both endovenous thermal ablation treatments result in significant improvements in quality of life and are likely to become increasingly popular in the future.
Nutritional modulation of metabolic phenotypes
Creators: name: Heinzmann, Silke
Publisher: name: Imperial College London
Year: 2010

description: Diet and other lifestyle factors play a critical role in the risk of developing many diseases. Metabolic profiles contain a wealth of biochemical and physiological information and are influenced by various factors such as gender, age, BMI or genetic background. Diet is an important factor, and long-term dietary habits as well as short-term food challenges influence the metabolic phenotype. Metabolic profiling technology can be used to discover novel single or combination biomarkers of food intake. To aid personalised healthy lifestyle recommendations, it is necessary to characterise the metabolic phenotype of individuals and to establish the extent to which we can beneficially influence this phenotype by nutritional intervention. This thesis aims to evaluate metabonomics as a tool for systematically detecting metabolites related to inter-individual and food-related differences. In order to address these aims a nutrition study was undertaken, where individuals followed a strict diet regime consuming a standard diet including specific food challenges, spot urine collections were made throughout the study period. 1H NMR spectroscopy was performed to generate urinary metabolic profiles, which were subsequently analysed and interpreted using multivariate mathematical modelling methods. Clear metabolic signatures pertaining to the consumption of specific dietary components and ‘biomarker’ metabolites associated with particular foods were extracted. Further validation of a potential biomarker was undertaken interrogating a large-scale epidemiologic dataset, the INTERMAP Study. Inter-individual variation in the metabolic profile was observed, both in relation to differences in response to food ingestion and metabolic differences independent from immediate food ingestion. Among these alterations were metabolites originating from gut microbial-mammalian co-metabolism. The influence of the gut microbiota on the metabolic phenotype and obesity was further investigated using microbially modulated murine models. This thesis characterises the effects of the interaction of diet and microbial metabolism on the metabolic phenotype and provides a template for assessing complex dietary interventions with respect to beneficially modulating metabolism.
Additional file 1 of Integrative multi-omics analysis reveals novel idiopathic pulmonary fibrosis endotypes associated with disease progression
Creators: name: Ruan, Peifeng
name: Todd, Jamie L
name: Zhao, Hongyu
name: Liu, Yi
name: Vinisko, Richard
name: Soellner, Julia F.
name: Schmid, Ramona
name: Kaner, Robert J.
name: Luckhardt, Tracy R.
name: Neely, Megan L.
name: Noth, Imre
name: Porteous, Mary
name: Raj, Rishi
name: Safdar, Zeenat
name: Strek, Mary E
name: Hesslinger, Christian
name: Palmer, Scott M.
name: Leonard, Thomas B.
name: Salisbury, Margaret L.
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: Virology
subject: Computational Biology

description: Additional file 1: Section S1. Process used to quantify proteins, toRNA, and miRNA and perform bioinformatics analyses.
Cytochrome P450 profiles in rat and their prediction from UPLC-MS metabolic profiles
Creators: name: Masson, Perrine Anne Sophie
Publisher: name: Imperial College London
Year: 2011

description: Cytochrome P450 enzymes (CYPs) are of great interest to pharmaceutical industry due to their major role in drug metabolism and drug-drug interactions in man. As CYPs also act on endogenous substrates and are regulated by nuclear receptors involved in biochemical pathways, their profiles are likely to affect endogenous metabolic profiles. The work in this thesis aimed to establish baseline rat liver CYP levels and assess relationships between CYP profiles and corresponding endogenous metabolic profiles, before introducing CYP inducers in subsequent projects to identify early biomarkers of CYP induction. An efficient and reproducible protocol was first developed and optimised for liver untargeted metabolic profiling by ultra performance liquid chromatography-mass spectrometry (UPLC-MS). Comparison of technical and biological variation for this liver protocol then demonstrated that sample preparation and UPLC-MS variability was mostly small compared to inter-animal variability. Subsequently, an in vivo study was designed including 20 male and 20 female Wistar rats. Liver mRNA of 81 CYPs was quantified, of which 23 exhibited significant gender differences with a gender ratio > 2. Clear gender differences were also observed in serum, urine and liver UPLC-MS metabolic profiles, e.g for metabolites belonging to steroid, triglyceride and phospholipid families. Multivariate models constructed to investigate relationships between CYP and metabolic profiles mainly highlighted the latent variable “gender”. Separate investigations for each gender yielded good prediction of CYP mRNA profiles from male liver aqueous metabolic profiles and female urine metabolic profiles. For prediction of CYP activities, the best models were obtained from serum metabolic profiles. In conclusion, this work improved our knowledge of rat basal CYP and metabolic profiles, and provides a strong basis for subsequent studies on CYP inducers. Importantly, strategies developed for UPLC-MS sample preparation, study design and data pre-processing/analysis are now routinely employed in our laboratory and have applications in many metabolic profiling studies.
SwissFlexWork 2014: Repräsentative Befragung der Schweizer Erwerbstätigen zur Verbreitung von mobiler Arbeit und Home Office
Creators: name: Weichbrodt, Johann
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2014
Subjects: subject: mobil-flexible Arbeit
subject: Schweiz
subject: 310 - Allgemeine Statistiken
subject: 150 - Psychologie

description: Die Studie bietet aktuelle und zuverlässige Zahlen zur Verbreitung von mobiler Arbeit und Home Office in der Schweiz. Im April 2014 wurden 1'819 Erwerbstätige (repräsentative Stichprobe) in der Deutsch- und Westschweiz zum Thema Arbeitsmobilität befragt. Die Ergebnisse zeigen, dass nur etwas weniger als die Hälfte der Schweizer Erwerbstätigen aufgrund ihrer Arbeitsaufgabe nicht mobil arbeiten können. Ein knappes Viertel arbeitet bereits regelmässig mobil und ein weiteres gutes Viertel macht dies entweder nur selten, oder möchte es nicht, oder kann nicht aufgrund fehlender Technik oder Erlaubnis.
title: Langzeitresultate des prospektiven Schweizer Registers „LDR-Brachytherapie des lokalisierten Prostatakarzinoms“
Creators: name: Schmid, H.-P.
name: Viktorin, P.
name: Putora, P. M.
name: Schiefer, J.
name: Schwab, C.
name: Plasswilm, L.
name: Engeler, D. S.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Die LDR-Brachytherapie ist eine effiziente Therapie für organbegrenzte Prostatakarzinome mit vergleichbaren onkologischen Resultaten wie die radikale Prostatektomie und die perkutane Radiotherapie. Die Daten stammen aber vorwiegend aus retrospektiven Analysen und monozentrischen Kohorten. Zwischen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
A Simple Leaning Trike
Creators: name: Nurse, Stephen
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Cycling is human-powered transport. It benefits society by providing exercise and low pollution, low cost transport, and by relieving roads of car traffic. But cycling in Australian cities has aspects which could be improved. Some bicycles are not designed to carry loads, which limits their use as transport, bicycles are often fully imported, which limits their contribution to the local economy and standardised bicycle design limits opportunity for self-expression. This research proposes cycles which are locally made, provide fulfilment using DIY, and have inbuilt load capacity.
The cycles are leaning trikes based on a solid-timber framed prototype developed prior to candidature and the research question is: How can DIY leaning trikes contribute to sustainable transport? The question is answered through this exegesis and the design, production and testing of trikes.
The research trikes are recumbent cycles, and background research on recumbents finds they must provide good value and be likable to be widely accepted. Six trikes have been designed, built and tested in everyday use, and they improve on the prototype by allowing customisation, using lightweight aluminium and plywood materials, and by using laser cutting, casting, numerically controlled routing, and 3d printing in their construction. Testing found them to be broadly reliable, enjoyable to make, and suitable for commuting and shopping.
The DIY leaning trikes built for this project have already been used as sustainable transport, however to contribute further, the trikes or machines they inspire must be made in quantity and used as transport.
Stärkung von Vertrauen, Kooperation und Partizipation durch den Einsatz digitaler Kommunikationstools
Creators: name: Peter, Josua
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2021

description: Um in der Gemeinde Wald im Kanton Appenzell Ausserhoden das gemeinschaftliche Zusammenleben innerhalb der Gemeinde zu verstärken, sollen Vertrauen, Kooperations- und Partizipationsbereitschaft zwischen der Gemeinde und den Einwohnerinnen und Einwohnern verstärkt werden. Die Kommunikation zwischen den Akteuren in der Gemeinde spielt als Schlüsselkomponente eine besondere Rolle in diesem Prozess. Da persönliche Kommunikation zunehmend seltener stattfindet, werden auch die Prozesse der Kooperation, Partizipation und des gegenseitigen Vertrauensaufbaus erschwert. Ziel der Masterarbeit ist die Ausarbeitung von möglichst passenden digitalen Kommunikationstools, die diesen Prozessen wieder Auftrieb verleihen. Um dieses Ziel zu erreichen wurde eine quantitative Bevölkerungsbefragung durchgeführt, in welcher die Wäldler Bevölkerung Aussagen zu ihrer momentanen und zukünftigen digitalen Mediennutzung machten. Die Umfrageergebnisse haben ergeben, dass sich insbesondere ein Weblog, in Kombination mit E-Petitionen, für eine Implementierung in Wald eignet.
The role of neuroinflammatory modulation on POCD development following surgery
Creators: name: Rei Fidalgo, Antonio Manuel
Publisher: name: Imperial College London
Year: 2011

description: The effects of peripheral surgery-induced inflammation and the role of the proinflammatory cytokine interleukin 1-beta (IL-1β) on cognitive function in mouse in several different contexts are explored. Lipopolysaccharide (LPS)-induced inflammation, but not isoflurane-induced anaesthesia, results in memory impairment in mouse, causing a permanent retrograde amnesia in contextual fear-conditioning tests. Blocking the action of IL-1β reduces the hippocampal memory deficit induced by LPS. Peripheral orthopaedic surgery results in inflammation in the brain and cognitive impairment in a mouse model of orthopaedic surgery. Such surgery is associated with increased levels of IL-1β in the serum and in the hippocampus. It also induces hippocampal microgliosis without being associated with an increase in apoptosis. Injection of an interleukin 1 receptor antagonist (IL1-ra) results in reduced microgliosis and reduced IL-1β levels in the serum and in the hippocampus. The inflammatory response to such surgical insult also results in impairment of remote (pre-frontal cortex (PFC)) localised memory in mouse as assessed by two tests of contextual remote memory. Such impairment is not accompanied by an increase in IL-1β in the PFC. There is also a reduction in the level of hippocampal brain derived neurotrophic factor (BDNF) which may contribute to the impairment of memory after such surgery. The murine anxiety response to peripheral orthopaedic surgery, as assessed using the social interaction test, shows that surgery does not increase anxiety in our animal model of peripheral surgery. Nor does such surgery affect olfactory memory under the conditions presented on the olfactory habituation-dishabituation task. A sub-pyrogenic dose of LPS alone fails to impair memory function. However, when the same is administered prior to peripheral surgery, it exacerbates surgery-induced cognitive dysfunction as assessed by fear-conditioning tests. It causes a concomitant additional increase in the levels of IL-1β in both plasma and hippocampus of those animals.
Identification and Characterization of a LIF-STAT3/Activin-Smad2/3 Dual Responsive Pluripotent Stem Cell State
Creators: name: Chang, Kuo-Hsuan
Publisher: name: Imperial College London
Year: 2010

description: The medical and bioindustrial applications of pluripotent stem cells rely on our understanding of their biology. Pluripotent stem cell lines derived from embryos in different stages depend on distinct signalling pathways. Embryonic stem cells (ESCs), derived from the inner cell mass (ICM) of preimplantation embryos, are dependent on LIF/STAT3 signalling, while epiblast stem cells (EpiSCs), established from the postimplantation embryos, require Activin A/Smad2/3 signalling. Recent studies revealed the presence of intermediate pluripotent stem cell populations. Their growth factor responsiveness, gene expression pattern and associated chromatic signatures, are compatible with the state intermediate between ESCs and EpiSCs. However, it remains unknown whether such cell populations represent a stable clonally intermediate cell state. In this thesis, I describe the discovery and characterization of novel stem cell lines displaying gene expression pattern intermediate between ESCs and EpiSCs. These cells respond to LIF/STAT3 as well as Activin/Smad2/3 signalling at single cell level. They can integrate into the ICM and generate chimeric embryos. In keeping with a more advanced differentiation stage than that of ESCs, the LIF/Activin dual responsive stem cells showed accelerated temporal gene expression kinetics during in vitro differentiation in embryo bodies. I found that these properties are shared by some induced pluripotent stem cell (iPSC) lines. The notion of an intermediate state was consolidated by a genome-wide microarray profiling. The hierarchical clustering analysis grouped LIF/Activin dual responsive stem cells together into a cluster intermediate between ESCs and EpiSCs. These findings advanced our understanding of the regulation of pluripotency. A better understanding of distinct differentiation state of pluripotent stem cells and their signalling responsiveness is crucial for developing tailored strategies for lineage/cell type differentiation.
title: Externe Validierung moderner auf MRT basierender Prostatakrebs-Risikomodelle
Creators: name: Distler, F. A.
name: Püllen, L.
name: Radtke, J.
name: Wiesenfarth, M.
name: Roobol, M.
name: Verbeek, J.
name: Wetter, A.
name: Guberina, N.
name: Pandey, A.
name: Hüttenbrink, C.
name: Tschirdewahn, S.
name: Pahernik, S.
name: Hadaschik, B.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Zielsetzung: In einer externen Kohorte sollen drei neue Risikomodelle, einschließlich des kürzlich aktualisierten Modells der European Randomized Study of Screening for Prostate Cancer (ERSPC), die multiparametrische Magnetresonanztomographie (mpMRI) und klinische Variablen kombinieren, um[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
title: Candidature projet Usages et gestion de la forêt méditerranéenne 2012
Creators: name: LA3M (UMR 7298)/LPED (UMR 151)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2019

description: Projet Usages et gestion de la forêt méditerranéenne, porté par Aline Durand (LA3M) et Didier Genin (LPED), en 2012.
One ligand capable of in situ reaction in a mixed-ligand system with two new different frameworks
Creators: name: Wang, Xiaofang
name: Wang, Runwei
name: Liu, Xiaofang
name: Zhu, Pinwen
name: Qiu, Shilun
Publisher: name: Taylor & Francis
Year: 2017
Subjects: Biophysics
Biochemistry
Medicine
Molecular Biology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Developmental Biology
Computational Biology

description: The in situ ligand 2,3-pyrazinedicarboxylic acid (2,3-H2pzdc) mixed with 1,1′-(1,4-butanediyl)bis(benzimidazole) (bbbi) is used to form two coordination polymers ([Cd(2,3-pzdc)(bbbi)] (1) and [Cd2Cl3(2-pzc)(bbbi)2] (2)) under hydrothermal conditions. Complex 1 was obtained in the absence of in situ reaction and 2 was synthesized with 2,3-H2pzdc in situ generating 2-pyrazinecarboxylate (2-pzc−). The structural details reveal that 1 has a 3D framework with dia topology, and 2 is a 2D layer structure and develops a 3D supramolecular structure via strong π⋯π stacking interactions. The ligand effects were compared for the two frameworks. In addition, fluorescence properties and thermal stabilities of 1 and 2 in the solid were studied.
The evolution of Cryptococcus neoformans var. grubii in the context of clinical disease using multilocus sequence typing
Creators: name: Simwami, Sitali P.
Publisher: name: Imperial College London
Year: 2011

description: The global burden of HIV-associated cryptococcal meningitis (CM) is estimated at one million cases per year, causing up to a third of all AIDS-related deaths. Cryptococcus neoformans variety grubii (Cng) is the most ubiquitous cause of cryptococcal meningitis worldwide, however patterns of molecular diversity are understudied across some geographical regions experiencing significant burdens of disease. Cryptococcus species are notable in the degree that virulence differs amongst lineages, and highly virulent emerging lineages are changing patterns of human disease both temporally and spatially. Molecular epidemiology constitutes the main methodology for understanding the factors underpinning the emergence of this understudied, yet increasingly important, group of pathogenic fungi. A multilocus sequence typing (MLST) scheme was used to characterise a genetically depauperate Cng population in Thailand, and a contrastingly highly diverse Cng population in Cape Town, South Africa. Sequence types (STs) from these populations were integrated into a dataset comprising global STs of Cng and patterns of range expansion were traced. Evidence from haplotypic networks and coalescent analyses revealed an ancestral African population of molecular type VNB, from which emerged a VNI lineage. This VNI lineage expanded globally out of Africa and led to the introduction of a limited number of genotypes in novel regions, including Asia. Bayesian inference estimated this spread of VNI to have occurred between 1 600 and 70 500 years ago, putatively vectored by the anthropogenically mediated spread of domesticated pigeons, historically native African birds. Clinical data collected from patients presenting with AIDS-associated CM showed that infecting African Cng isolates were associated with poorer long-term survival compared to Asian isolates. As mortality rates reported for these patients in Sub-Saharan Africa are higher than those seen in Asia, supported by a Galleria mellonella virulence model, this apparently elevated virulence is postulated as being the result of recombinant progeny with diverse phenotypes being created through frequent meiotic recombination.
The Health & Fitness Journal of Canada, Vol. 15 No. 1 (2022)
Creators: name: Health, The
Publisher: name: The Health & Fitness Journal of Canada
Year: 2022

description: Utility of an outdoor group exercise program for improving postpartum mental health...18-30 Menstrual dysfunction in youth female athletes and their management in the context of models of energy deficiency...3-17
Professionsbranding in Zeiten des Fachkräftemangels
Creators: name: Resch, Dörte
name: Weber, Selina
Publisher: name: Pabst Science Publishers
Year: 2023
Subjects: subject: Employer Branding
subject: Professionsbranding
subject: Fachkräftemangel
subject: Geschlechterstereotype
subject: 150 - Psychologie

description: Die meisten Berufsbilder sind stereotyp geprägt. Dadurch interessieren sich viele Berufssuchende nicht für bestimmte Berufe, obwohl sie dafür geeignet wären. Gleichzeitig ist die Realität in den Berufsfeldern sehr vielfältig und somit für eine breite Zielgruppe interessant. Branding hat sich im HR in den letzten Jahren besonders als Employer Branding für Arbeitgebende etabliert. In diesem Beitrag wird aufgezeigt, wie ein identitätsfokussiertes Professionsbranding als übergeordnetes Vorgehen zu Employer Branding angewendet werden kann. So wird die Attraktivität von Berufen für eine breitere Zielgruppe gesteigert und dadurch dem Fachkräftemangel entgegengewirkt. Die Vorgehensweise wird anhand von Projekten aus dem Informatik- und dem Hochschulbereich aufgezeigt. Diskursanalytische Untersuchungen in diesen Projekten zum aktuellen Image der Berufe zeigten, wie die Berufsbilder auch geschlechterstereotyp geprägt sind. Daher wurde nachfolgend der Frage nachgegangen, wie das Image der Professionen durch eine Re-Branding so verändert werden kann, dass es für alle Geschlechter attraktiver wird. Im Anschluss wurden neue Markenidentitäten und Arbeitgeber*innenversprechen für eine geschlechterintegratives und damit attraktive Darstellung der Professionen erarbeitet. Die anschließende Evaluation der Umsetzung ergab eine signifikante Steigerung der Attraktivität in der relevanten Zielgruppe.
Inner-Branched Endoprostheses for the Treatment of Aortic Arch Aneurysms
Creators: name: CHARLES PETER EDWARD MILNE
Publisher: name: Monash University
Year: 2017
Subjects: subject: 110323 Surgery
subject: FOS: Clinical medicine

description: The ‘inner branched’ endograft from Cook Medical (Bloomington, Ind) is a new technology designed to treat patients with extensive aortic arch aneurysms who are at high-risk for open surgery without the need for sternotomy. This thesis establishes criteria for patient selection and the procedural technique. Mid-term patient outcomes are presented. A CT-based feasibility study looking at the use of the endograft in patients following ascending aortic replacement for acute type A dissection is presented. Results of a CT-based long-term follow up study for patients having undergone thoracic endovascular aortic repair for blunt aortic injury are presented.
title: Wie häufig bleiben klinisch-signifikante Prostatakarzinome unentdeckt? Vergleich der MR/US Fusionsbiopsie der Prostata mit dem endgültigen Ergebnis anhand der Histologie inkl. Großflächenschnitten nach radikaler Prostatektomie
Creators: name: Doblhammer, S.
name: Kinger, P.
name: Brössner, C.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Fragestellung: Die MR/US Fusionsbiopsie der Prostata ist spätestens seit den aktuellen Leitlinien ein fester Bestandteil bei der Detektion des Prostatakarzinoms im Rahmen der Primärdiagnostik. Unterschiede zwischen der Lokalisation der PIRADS-Läsion, der Histologie der Biopsie und[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
Maternal prenatal stress and fetal programming: long term biobehavioural outcomes in the child and potential placental mechanisms
Creators: name: O'Donnell, Kieran J.
Publisher: name: Imperial College London
Year: 2010

description: Mounting evidence suggests prenatal stress can affect child development. Clinical studies of this concept, termed fetal programming, focus predominantly on early childhood. Also, little is known about the mechanisms underlying how maternal stress is transmitted to the fetus. This thesis will test if maternal anxiety during pregnancy is associated with (1) behavioural outcomes from childhood to early adolescence, (2) cortisol output in adolescence and (3) an altered placental phenotype. For Studies 1 and 2 participants were drawn from the Avon Longitudinal Study of Parents and Children (ALSPAC). Psychometric data from 9,871 mother child pairs (5,098 males, 4,773 females) were analysed using latent growth curve analysis. A subsample of the ALSPAC children aged 15 years (n = 899) provided saliva samples on three days at waking, +35mins, after school and before bed, for later cortisol analysis. For Study 3 a new cohort of women (n= 73) was recruited. Maternal psychometric data was collected one day prior to elective caesarean section, and the placenta collected after delivery. Study 1 showed that maternal prenatal anxiety was associated with conduct and emotional problems, and symptoms of ADHD at age 13 years, after allowing for a range of confounders, including postnatal anxiety. There were marked sex differences in the developing patterns. Saliva cortisol demonstrated a marked diurnal profile with a clear sex difference at age 15. Higher maternal prenatal anxiety was associated with a reduced cortisol awakening response. High levels of maternal prenatal anxiety were associated with reduced placental expression and activity of the cortisol metabolising enzyme 11β-Hydroxy steroid dehydrogenase 2 (11β-HSD2) and also with reduced placental weight. This thesis provides evidence that maternal prenatal anxiety can affect behavioural and neuroendocrine outcomes in adolescence. It also provides preliminary evidence that maternal anxiety is associated with alterations in the function of the placenta, which may underlie some aspects of fetal programming. These findings have public health implications. Increasing awareness about the lasting effects of prenatal anxiety may ultimately benefit mothers, the care they receive and their families.
Additional file 1 of Post-infection functional gastrointestinal disorders following coronavirus disease-19: a prospective follow-up cohort study
Creators: name: Zhang, Daya
name: Chen, Chen
name: Xie, Yunqian
name: Zeng, Fan
name: Chen, Shiju
name: Chen, Runxiang
name: Zhang, Xiaodong
name: Huang, Shimei
name: Li, Da
name: Bai, Feihu
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Supplementary Material 1