cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
β1 Integrin Regulates PC3 Prostate Cancer Cell Phenotypes in part via Regulation of Matricellular SPARC
Creators: name: Bugiel, Steven
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Prostate Cancer
Metastasis
Integrins
Extracellular Matrix
SPARC

description: We have shown herein that β1 integrin stably depleted PC3 sub-clonal cells confer a trend towards increased survival of mice compared to β1 integrin expressing counterparts when tested in an intracardial bone metastasis model. Therefore, we sought to investigate novel factors that mediate β1 integrin-dependent cellular migration and three dimensional growth of prostate cancer PC3 cells in vitro. We show herein that depletion of β1 integrin using siRNA directed techniques results in increased SPARC protein expression. We further show that suppression of SPARC by β1 integrin appears to occur through a JNK dependent mechanism. Moreover, siRNA mediated depletion of β1 integrin results in impaired sphere formation in 3D BME assays. This was mediated in part by the increased production of SPARC. β1 integrin-depleted cells also diminished the enhanced migration of cells on the predominant bone matrix, collagen I. Concomitant SPARC depletion in β1 integrin-depleted cells did not rescue this enhanced migration. These findings suggests that the role of β1 integrin in mediating 3D growth of PC3 cells occurs at least in part through the suppression of SPARC protein expression.
Characterization and Elucidation of Genomic Modifiers of DJ-1 and LRRK2 Animal Models of Parkinson’s Disease
Creators: name: Marcogliese, Paul C.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Parkinson's disease
DJ-1
LRRK2

description: Parkinson’s disease (PD) is a common neurodegenerative disorder symptomatically characterized by motor dysfunction caused by the selective loss of nigral dopamine neurons within midbrain. The pathogenesis of PD remains unclear. Although, originally thought to be sporadic, about ten percent of PD is familial. The recent elucidation of mutations in genes linked to the disease has offered potential for new animal models and understanding of PD pathogenesis. DJ-1 and LRRK2 are genes linked to autosomal recessive juvenile-onset PD and autosomal-dominant late onset PD, respectively. How mutations in these two genes leads to PD remains uncertain and is plagued by poor murine models that do not recapitulate the human condition. The following dissertation attempts to characterize both mouse and fly models of DJ-1 and LRRK2 mediated PD and elucidate other genetic modifiers that may contribute to PD. Firstly, the DJ-1 null mouse model, which lacks cell death, was improved by backcrossing to a pure C57-Bl6 background. These DJ-1 null mice display a robust and progressive unilateral-to-bilateral loss of nigral neurons accompanied by motor deficits in aged mice. Secondly, a large scale screen was performed in Drosophila to determine genes that modify mutant LRRK2 toxicity in both the eye and dopaminergic neurons of the fly. The screen revealed 36 genetic interactors that either suppressed or enhanced LRRK2 induced cell death in the fly. One of these interactors was SCAR (human WAVE-2). Due to the role WAVE-2 is known to have in immune cell phagocytic function, we demonstrate that LRRK2 deficient/G2019S murine myeloid cells have impaired/enhanced phagocytic activity which is correlated with a decrease/increase in WAVE-2 protein, respectively. We furthermore suggest that LRRK2 and WAVE-2 may bind directly and that LRRK2 phosphorylates WAVE-2 to maintain its stability. Finally, as a proof of concept, we constructed a novel animal model of LRRK2 in flies by limiting LRRK2 over expression to central phagocytes of the Drosophila brain. This causes lifespan deficits and motor dysfunction that can be rescued by down-regulation of SCAR. Collectively, this body of work helped create the first germ-line, genetic model of PD that recapitulates nigral loss and elucidated LRRK2 interactors in the fly. Furthermore, we demonstrate that one of these interactors mediated LRRK2’s modulation of phagocytic activity that may contribute to the pathogenesis of PD.
VAFB-2022-17: Archaeological Studies in 2019–2020 Supporting Section 106 Compliance for the Firebreaks and Access Roads Maintenance Program, Vandenberg Space Force Base, Santa Barbara County, California
Creators: name: Pitts-Olmedo, Karin
name: Nocerino, Eric
name: Lebow, Clayton G.
name: Harro, Douglas
name: McKim, Rebecca
name: Newcomb, Michelle
name: Munns, Ann
Year: 2022

description: This document is a Section 106 report that presents the study and results of the 2019–2020 Firebreaks and Access Roads Maintenance Program. Across Vandenberg Space Force Base (SFB), there is an extensive system of about 54 miles of firebreaks and 192 miles of associated roads. Many of these firebreaks and access roads are maintained on an annual basis. There are more than 2,100 archaeological resources on Vandenberg SFB, and firebreaks and access roads coincide with archaeological resources in 170 locations. There is potential for disturbances to archaeological resources resulting from firebreak and access road maintenance. Maintenance of firebreaks and access roads is an undertaking subject to compliance with Section 106 of the National Historic Preservation Act of 1966, as amended. To support that compliance and augment work previously completed, the United States Space Force retained Argonne National Laboratory to complete study of 15 archaeological sites that are associated with firebreak maintenance.

During background research, two of the sites (CA-SBA-1998 and CA-SBA-1999) targeted for National Register of Historic Places (NRHP) evaluations were found to extend outside
Vandenberg SFB and thus could not be evaluated. Consequently, those sites were assumed to be eligible for the NRHP and testing was completed to assess effects from firebreak maintenance. CA-SBA-246/H, targeted for assumed eligibility for the NRHP, clearly had enough data potential to support an evaluation of eligibility and thus was evaluated. Archaeological testing was completed at two archaeological sites that have been determined eligible for the NRHP, CA-SBA-1993 and CA-SBA-512, to assess effects from firebreak maintenance.

The resulting purpose of the investigations was to conduct archaeological testing or use the results of previous testing to assess effects at 10 sites eligible or assumed eligible for the NRHP and evaluate the NRHP eligibility of 5 additional sites.
Do commodity prices affect exchange rate differently in developed and developing countries? A comparative study of OECD and ASEAN
Creators: name: Tran, Thi Anh Thu
Publisher: name: Swinburne
Year: 2024

description: In this thesis are compared the relationship between exchange rate and commodity prices between OECD and ASEAN commodity-exporting countries. Based on the similarity between OECD and ASEAN in terms of demographics, commodity export, financial markets, economic performance, and development prospects, the thesis makes some predictions for the relationship between real exchange rate and real commodity prices in ASEAN developing commodity-exporting countries when they reach 'developed country' status. Moreover, this thesis gives some policy implications for these countries in the management of commodity prices and exchange rate during the transition period. The relationship between real exchange rate and real commodity prices in the two groups of countries is examined in terms of cointegration, elasticity of real exchange rate to real commodity prices, and Granger causality by employing both time-series and panel-data techniques. The test results indicate that there is a considerable difference in this relationship between developed and developing commodity-exporting countries. Specifically, in OECD commodity-exporting countries, real commodity prices and real exchange rate move together in the same direction in the long run and changes in real commodity prices will lead to responses of real exchange rate in order to re-establish the equilibrium. Meanwhile, in ASEAN commodity-exporting countries, real commodity prices and real exchange rate do not seem to have long-term relationship. This thesis also gives explanations for the differences in the relationship between OECD and ASEAN commodity-exporting countries: differences in exchange rate regimes, ability to expand the natural-resource sector, and level of financial openness between the two groups of countries. It is expected that on the way to achieving the 'developed country' status, the three factors of ASEAN commodity-exporting countries would be likely to evolve toward the trend currently seen in OECD commodity-exporting countries and the relationship between real commodity prices and real exchange rate would become stronger. However, a stronger relationship between real exchange rate and real commodity prices might be harmful to the economy, especially when the financial system is underdeveloped. To reduce the negative effects of the relationship on the overall economy in the transition period, this thesis suggests that ASEAN commodity-exporting countries smooth their government spending, diversify export commodities and diversify their economies.
What is the International Landscape of Essential Medicine Patent Protection and How Can Developing Countries' Medicine Access be Accelerated Within It?
Creators: name: Beall, Reed
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: Population health
Access to medicines
Pharmaceuticals
Patents
Trade
HIV/AIDS
Global health

description: This project is at the controversial intersection of medicine patent protection and access to medicines at the international level. Advocates for medicine access argue that medicine patent protection may allow prices to become elevated, thereby frustrating medicine access. But advocates for medicine patent protection argue that the patent system incentivized the research and development to make the product possible in the first place. While this ideological debate is valuable, this doctoral project acknowledges the patent system’s existence and seeks to produce research to advance medicine access pragmatically within this context, especially in developing countries and especially for drugs appearing on the World Health Organization’s Model List of Essential Medicines (MLEM). In cooperation with the World Intellectual Property Organization, this project commenced with a legal study to assess the patent status of the entire MLEM (375 medicines) in 137 developing countries. Gathering these patent data and verifying them with global pharmaceutical suppliers was this project’s principal data collection. The patent data were further linked to development indicators of the countries implicated by our study and to economic data detailing medicine procurements made by those working with assistance from international organizations. Building upon the techniques refined during the MLEM study, three supplementary patent studies were performed to investigate very specific questions regarding medicine patenting and medicine access. With these patent data collected, we investigated companies’ medicine patent filing behaviours internationally. Various policy approaches to accelerating access at the international level were compared, including those that disregard patent protection and those are based on cooperation between medicine suppliers. Of the approaches considered, the cooperative approaches appeared to be the most efficient, especially voluntary licensing practices (i.e., originator companies license generic manufacturers to supply the product to developing countries in exchange for royalties). We find that while patents may detour generic competition at times, we also find they may serve as springboards for collaborative endeavours and global medicine access campaigns, like the one for HIV drugs. This thesis concludes by arguing that improved international medicine patent transparency by pharmaceutical suppliers is one of the most powerful ways to foster such collaborations to improve medicine access.
Supplementary Material from Brightness cues affect gap negotiation behaviours in zebra finches flying between perches
Creators: name: Borsier, Emma
name: Sanders, Helen
name: Taylor, Graham Keith
Publisher: name: The Royal Society
Year: 2024
Subjects: classificationCode: 310901
subject: Animal behaviour

description: Supplementary Methods, Supplementary Table S1, and Supplementary Figures S1-S4.
VAFB-2000-16: Preliminary Draft Archaeological Survey of San Antonio Creek Cutbanks, VAFB, SB Co., CA.
Creators: name: Lebow, Clayton G.
Year: 2000

description: This document is a report that describes cultural resource investigations for the El Rancho Road Bridge Project. A total of 19 cultural resources were identified in the project area. Survey was completed at cut-banks along San Antonio Creek in the vicinity of the proposed bridge. One new site, CA-SBA-3511, was identified during the survey.
A Density Functional Theory Study of Magnetic Transition in MnO2 adsorbed Vanadium Carbide (V$_2$C) MXene
Creators: name: Fatima, Mahjabeen
name: Khan, Saleem Ayaz
name: Rizwan, Syed
Publisher: name: arXiv
Year: 2024
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: The work reports nonmagnetic behavior (0.04 $μ$B) in two-dimensional (2D) V2C-OF MXene and ferromagnetism in MnO$_2$ adsorbed V2C-OF MXene. The density functional theory (DFT) calculations were carried out to study the magnetic moments of V$_2$C-OF and MnO$_2$@V$_2$C-OF MXene. The MXene, which is derived from the exfoliation of its parent V$_2$AlC MAX phase, shows a good potential to be a ferromagnetic when MnO$_2$ is adsorbed on it. The V$_2$C MXene and MnO$_2$ adsorbed V$_2$C MXene were successfully synthesized, as characterized using X-ray diffraction, showing an increased c-lattice parameter from 22.6Å to 27.2Å after MnO$_2$ adsorption. The DFT study confirmed that MnO$_2$ adsorbed V$_2$C MXene changed from nonmagnetic (in V$_2$C MXene) to a strong ferromagnetic with a magnetic moment of 4.48$μ$B for Mn adsorbed V$_2$C-OF MXene. The current work is a step-forward towards understanding of magnetism in two-dimensional materials for future 2D spintronics.
CDX2 Regulates Gene Expression Through Recruitment of BRG1-Associated SWI/SNF Chromatin Remodeling Activity
Creators: name: Nguyen, Thinh
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Cdx2
transcription
Brg1
SWI/SNF
Chromatin Remodeling
development

description: The packaging of genomic DNA into nucleosomes creates a barrier to transcription which can be relieved through ATP-dependent chromatin remodeling via complexes such as the switch/sucrose non-fermentable (SWI/SNF) chromatin remodeling complex. The SWI/SNF complex remodels chromatin via conformational or positional changes of nucleosomes, thereby altering the access of transcriptional machinery to target genes. The SWI/SNF complex does not possess intrinsic DNA binding ability, and therefore its recruitment to target loci requires interaction with DNA-associated transcription factors. The Cdx family of homeodomain transcription factors (Cdx1, Cdx2 and Cdx4) are essential for a number of developmental programs in the mouse. Cdx1 and Cdx2 also regulate intestinal homeostasis throughout life. Although a number of Cdx target genes have been identified, the basis by which Cdx members impact their transcription is poorly understood. We have found that Cdx members interact with the SWI/SNF complex and make direct contact with Brg1, a catalytic member of SWI/SNF. Both Cdx2 and Brg1 co-occupy a number of Cdx target genes, and both factors are necessary for transcriptional regulation of such targets. Finally, Cdx2 and Brg1 occupancy occurs coincident with chromatin remodeling at certain of these loci. Taken together, our findings suggest that Cdx transcription factors regulate target gene expression, in part, through recruitment of Brg1-associated SWI/SNF chromatin remodeling activity.
From Mesh to Neural Nets: A Multi-Method Evaluation of Physics-Informed Neural Networks and Galerkin Finite Element Method for Solving Nonlinear Convection-Reaction-Diffusion Equations
Creators: name: Hasan, Fardous
name: Ali, Hazrat
name: Arief, Hasan Asyari
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computational Physics (physics.comp-ph)
subject: Numerical Analysis (math.NA)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: Non-linear convection-reaction-diffusion (CRD) partial differential equations (PDEs) are crucial for modeling complex phenomena in fields such as biology, ecology, population dynamics, physics, and engineering. Numerical approximation of these non-linear systems is essential due to the challenges of obtaining exact solutions. Traditionally, the Galerkin finite element method (GFEM) has been the standard computational tool for solving these PDEs. With the advancements in machine learning, Physics-Informed Neural Network (PINN) has emerged as a promising alternative for approximating non-linear PDEs.
 In this study, we compare the performance of PINN and GFEM by solving four distinct one-dimensional CRD problems with varying initial and boundary conditions and evaluate the performance of PINN over GFEM. This evaluation metrics includes error estimates, and visual representations of the solutions, supported by statistical methods such as the root mean squared error (RMSE), the standard deviation of error, the the Wilcoxon Signed-Rank Test and the coefficient of variation (CV) test.
 Our findings reveal that while both methods achieve solutions close to the analytical results, PINN demonstrate superior accuracy and efficiency. PINN achieved significantly lower RMSE values and smaller standard deviations for Burgers' equation, Fisher's equation, and Newell-Whitehead-Segel equation, indicating higher accuracy and greater consistency. While GFEM shows slightly better accuracy for the Burgers-Huxley equation, its performance was less consistent over time. In contrast, PINN exhibit more reliable and robust performance, highlighting their potential as a cutting-edge approach for solving non-linear PDEs.
description: 29 pages, 13 figures
VAFB-2019-14: Identification of Historic Properties and Assessment of Effects TP-01 Improvements Supporting Future Ballistic Missile Test Launches
Creators: name: Ryan, Christopher
name: Smallwood, Josh
Year: 2019

description: This government generated Section 106 report is a historic property inventory and assessment of adverse effects associated with the TP-01 Improvements Supporting Future Ballistic Missile Test Launches Project. The purpose of the document is to compile any prior or currrent studies performed in support of the TP-01 improvements supporting future Ballistic Missile Test launches as a single Section 106 report. This report provides the information needed by the California State Historic Preservation Officer to concur on the project findings and determinations for individual resources as presented by the Vandenberg Air Force Base Cultural Resource Manager. The report specifically examines project impacts and/or avoidance strategies for 2 archaeological sites; CA-SBA-1155, -1687; and for one built environment resource; TP-01 (Facility 1840, P-42-041280).
The stress-energy tensor of an Unruh-DeWitt detector
Creators: name: Perche, T. Rick
name: Pitelli, J. P. M.
name: Vanzella, Daniel A. T.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Quantum Physics (quant-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We propose a model for a finite-size particle detector, which allows us to derive its stress-energy tensor. This tensor is obtained from a covariant Lagrangian that describes not only the quantum field that models the detector, $ϕ_{\text{d}}$, but also the systems responsible for its localization: a complex scalar field, $ψ_{\text{c}}$, and a perfect fluid. The local interaction between the detector and the complex field ensures the square integrability of the detector modes, while the fluid serves to define the spatial profile of $ψ_{\text{c}}$, localizing it in space. We then demonstrate that, under very general conditions, the resulting energy tensor -- incorporating all components of the system -- is physically reasonable and satisfies the energy conditions.
description: 11 pages, 7 figures, revtex 4.2
Communists vs. Conservatives and the Struggle for the Hungarian Soul in Canada, 1940-1989
Creators: name: Adam, Christopher Peter
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Hungarian
Canadian
Ethnicity
Diaspora
Hungary
Communist Party of Canada
Budapest
Multiculturalism

description: This thesis explores the pervasive political divide within Canada’s Hungarian communities between communists and nationalist conservatives. Both sides in this conflict struggled for ownership of Hungarian national symbols and the right to be seen as the “true” guardians of Hungarian identity in Canada. While religious differences between Roman Catholic and Calvinist Hungarian immigrants served as a divisive force in the late nineteenth and early twentieth century, the arrival of a massive wave of new immigrants from the lands of the defunct Austro-Hungarian Empire after the First World War introduced into Canada the fiery political divisions between the far left and right that engulfed Hungary in 1918/19. Throughout the interwar period, during the Second World War and in the Cold War era, successive regimes in Budapest intervened, further politicized and divided Canada’s Hungarian communities, separating them into “loyal” and “disloyal” camps. But both communist and conservative Hungarian-Canadian leaders demonstrated a significant level of agency by often charting their own course and thus confounding their allies in Budapest. This thesis argues that Hungarian-Canadian communists only paid lip service to the Marxist language of class conflict, while national self-identification trumped class-based identity or internationalism, and conservative nationalists represented a large, politically heterogeneous camp, divided by generational conflicts and tensions between immigrant cohorts.
Can breastfeeding protect against antimicrobial resistance?
Creators: name: Nadimpalli, Maya L
name: Bourke, Claire D
name: Robertson, Ruairi C
name: Delarocque-Astagneau, Elisabeth
name: Manges, Amee R.
name: Pickering, Amy J
Publisher: name: BioMed Central
Year: 2020

description: Background: The proportion of infections among young children that are antimicrobial-resistant is increasing across the globe. Newborns may be colonized with enteric antimicrobial-resistant pathogens early in life, which is a risk factor for infection-related morbidity and mortality. Breastfeeding is actively promoted worldwide for its beneficial impacts on newborn health and gut health. However, the role of breastfeeding and human milk components in mitigating young children’s carriage of antimicrobial-resistant pathogens and antibiotic resistance genes has not been comprehensively explored. Main body: Here, we review how the act of breastfeeding, early breastfeeding, and/or human milk components, such as the milk microbiota, secretory IgA, human milk oligosaccharides, antimicrobial peptides, and microRNA -bearing extracellular vesicles, could play a role in preventing the establishment of antimicrobial-resistant pathogens in young children’s developing gut microbiomes. We describe findings from recent human studies that support this concept. Conclusion: Given the projected rise in global morbidity and mortality that will stem from antimicrobial-resistant infections, identifying behavioral or nutritional interventions that could decrease children’s susceptibility to colonization with antimicrobial-resistant pathogens may be one strategy for protecting their health. We suggest that breastfeeding and human milk supplements deserve greater attention as potential preventive measures in the global effort to combat antimicrobial resistance, particularly in low- and middle-income settings.
Neuron splitting for efficient feature map formation
Creators: name: Andrew, Lachlan L. H.
Publisher: name: Swinburne
Year: 2024

description: Kohonen's Self Organizing Feature Map (SOFM) produces an ordered mapping from one space to another. This paper describes an algorithm inspired by the splitting initialization for the classical LBG method for vector quantizer design, which allows the efficient generation of maps with various topologies and with high local and global ordering.
How quantum computing can enhance biomarker discovery
Creators: name: Flöther, Frederik F.
name: Blankenberg, Daniel
name: Demidik, Maria
name: Jansen, Karl
name: Krishnakumar, Raga
name: Krishnakumar, Rajiv
name: Laanait, Nouamane
name: Parida, Laxmi
name: Saab, Carl
name: Utro, Filippo
Publisher: name: arXiv
Year: 2024
Subjects: subject: Other Quantitative Biology (q-bio.OT)
subject: Quantum Physics (quant-ph)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: Biomarkers play a central role in medicine's gradual progress towards proactive, personalized precision diagnostics and interventions. However, finding biomarkers that provide very early indicators of a change in health status, for example for multi-factorial diseases, has been challenging. Discovery of such biomarkers stands to benefit significantly from advanced information processing and means to detect complex correlations, which quantum computing offers. In this perspective paper, quantum algorithms, particularly in machine learning, are mapped to key applications in biomarker discovery. The opportunities and challenges associated with the algorithms and applications are discussed. The analysis is structured according to different data types - multi-dimensional, time series, and erroneous data - and covers key data modalities in healthcare - electronic health records (EHRs), omics, and medical images. An outlook is provided concerning open research challenges.
"Früh, wenn die Hähne krähn" : [für Männerchor]
Creators: name: Reiter, Ernst
name: Mörike, Eduard
Publisher: name: [s.n.]
Year: 1870

description: Ernst Reiter ; [Text] von Mörike
description: Geschenk 1935 *35.2332 Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire 2013 Übernahme Rekatalogis. AK UB durch Medea 2002-2005
description: Digitalisierung=Digitization=Numérisation Mai 2024 TIFF
Steady State Response of Thin-walled Members Under Harmonic Forces
Creators: name: Mohammed Ali, Hjaji
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: thin-walled member
harmonic force
closed form solution
exact shape function
finite element

description: The steady state response of thin-walled members subjected to harmonic forces is investigated in the present study. The governing differential equations of motion and associated boundary conditions are derived from the Hamilton variational principle. The harmonic form of the applied forces is exploited to eliminate the need to discretize the problem in the time domain, resulting in computational efficiency. The formulation is based on a generalization of the Timoshenko-Vlasov beam theory and accounts for warping effects, shear deformation effects due to bending and non-uniform warping, translational and rotary inertial effects and captures flexural-torsional coupling arising in asymmetric cross-sections. Six of the resulting seven field equations are observed to be fully coupled for asymmetric cross-sections while the equation of longitudinal motion is observed to be uncoupled. Separate closed form solutions are provided for the cases of (i) doubly symmetric cross sections, (ii) monosymmetric cross-sections, and (iii) asymmetric cross-sections. The closed-form solutions are provided for cantilever and simply-supported boundary conditions. A family of shape functions is then developed based on the exact solution of the homogeneous field equations and then used to formulate a series of super-convergent finite beam elements. The resulting two-noded beam elements are shown to successfully capture the static and dynamic responses of thin-walled members. The finite elements developed involve no special discretization errors normally encountered in other finite element formulations and provide results in excellent agreement with those based on other established finite elements with a minimal number of degrees of freedom. The formulation is also capable to predict the natural frequencies and mode-shapes of the structural members. Comparisons with non-shear deformable beam solutions demonstrate the importance of shear deformation effects within short-span members subjected to harmonic loads with higher exciting frequencies. Comparisons with shell element solution results demonstrate that distortional effects are more pronounced in cantilevers with short spans. A generalized stress extraction scheme from the finite element formulation is then developed. Also, a generalization of the analysis procedure to accommodate multiple loads with distinct exciting frequencies is established. The study is concluded with design examples which illustrate the applicability of the formulation, in conjunction with established principles of fatigue design, in determining the fatigue life of steel members subjected to multiple harmonic forces.
Psychological Health and Physical Activity Levels during the COVID-19 Pandemic: A Systematic Review
Creators: name: Violant-Holz, Verónica
name: Gallego-Jiménez, M. Gloria
name: González-González, Carina S.
name: Muñoz-Violant, Sarah
name: Rodríguez, Manuel José
name: Sansano-Nadal, Oriol
name: Guerra-Balic, Myriam
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2021

description: The coronavirus disease (COVID-19) pandemic has been devastating in all senses, particularly psychologically. Physical activity (PA) is known to aid psychological well-being, and it is worth investigating whether PA has been a coping strategy during this pandemic. The objective of this literature review is to analyze the extent to which engaging in PA during the COVID-19 pandemic impacts psychological health in the adult population. The literature was searched in all databases from the EBSCOhost Research Database—MEDLINE, APA PsycArticles, between others—published between 1 January 2019 and 15 July 2020. From 180 articles found, 15 were eligible. The reviewed articles showed an association between mental health distress—e.g., stress, anxiety, depressive symptoms, social isolation, psychological distress—and PA. This research concludes that the COVID-19 pandemic and the lockdown measures caused psychological distress. Those studies that analyzed PA showed that, during quarantine, adults increased their sedentary time and reduced their PA levels, showing controversial psychological outcomes. This review discusses whether PA is an effective strategy to face the COVID-19 pandemic psychological effects contributing to a further putative increase in the prevalence of psychiatric disorders.
Theodor Heusser an Theodor und Regina Heusser-von Flugi
Creators: name: Heusser, Theodor
Publisher: name: [s.n.]
Year: 1874

description: Textincipit: "Liebe Eltern! / Ich hoffe, dass Euch die Zeilen / die ich an Euch geschickt beruhigt haben werden [...]"
Photonic Generation of Microwave and Millimeter Wave Signals
Creators: name: Li, Wangzhe
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: terahertz
oeo
optoelectronic oscillator
microwave
millimeter wave
external modulation

description: Photonic generation of ultra-low phase noise and frequency-tunable microwave or millimeter-wave (mm-wave) signals has been a topic of interest in the last few years. Advanced photonic techniques, especially the recent advancement in photonic components, have enabled the generation of microwave and mm-wave signals at high frequencies with a large tunable range and ultra-low phase noise. In this thesis, techniques to generate microwave and mm-wave signals in the optical domain are investigated, with an emphasis on system architectures to achieve large frequency tunability and low phase noise. The thesis consists of two parts. In the first part, techniques to generate microwave and mm-wave signals based on microwave frequency multiplication are investigated. Microwave frequency multiplication can be realized in the optical domain based on external modulation using a Mach-Zehnder modulator (MZM), but with limited multiplication factor. Microwave frequency multiplication based on external modulation using two cascaded MZMs to provide a larger multiplication factor has been proposed, but no generalized approach has been developed. In this thesis, a generalized approach to achieving microwave frequency multiplication using two cascaded MZMs is presented. A theoretical analysis leading to the operating conditions to achieve frequency quadrupling, sextupling or octupling is developed. The system performance in terms of phase noise, tunability and stability is investigated. To achieve microwave generation with a frequency multiplication factor (FMF) of 12, a technique based on a joint operation of polarization modulation, four-wave mixing and stimulated-Brillouin-scattering-assisted filtering is also proposed. The generation of a frequency-tunable mm-wave signal from 48 to 132 GHz is demonstrated. The proposed architecture can even potentially boost the FMF up to 24. In the second part, techniques to generate ultra-low phase noise and frequency-tunable microwave and mm-wave signals based on an optoelectronic oscillator (OEO) are studied. The key component in an OEO to achieve low phase noise and large frequency-tunable operation is the microwave bandpass filter. In the thesis, we first develop a microwave photonic filter with an ultra-narrow passband and large tunability based on a phase-shifted fiber Bragg grating (PS-FBG). Then, an OEO incorporating such a microwave photonic filter is developed. The performance including the tunable range and phase noise is evaluated. To further increase the frequency tunable range, a technique to achieve microwave frequency multiplication in an OEO is proposed. An mm-wave signal with a tunable range more than 40 GHz is demonstrated.
Nudging Scientific Advancement through Reviews
Creators: name: Posina, Venkata Rayudu
name: Nathan, Hippu Salk K.
name: Behera, A.
Publisher: name: Zenodo
Year: 2020
Subjects: Nudge
Review
Science
Theory
Experiment
Putting together
Original finding

description: We call for a change-of-attitude towards reviews of scientific literature. We begin with an acknowledgement of reviews as pathways for the advancement of our scientific understanding of reality. The significance of the scientific struggle propelling the putting together of pieces of knowledge into parts of a cohesive body of understanding is recognized, and yet undervalued, especially in empirical sciences. Here we propose a nudge, which is prefacing the insights gained in reviewing the literature with: 'Our review reveals' (or an equivalent phrase), that can bring about the desired cultural shift in the practice of science. The resulting elevation of the status of reviews to that of original findings would also bring about the desirable smoothening of the undesirable schism between theorists and experimentalists.
description: Mandating 'Our review reveals' will elevate the status of reviews to that of original findings.
description: {"references": ["D. Geman, S. Geman, Science in the age of selfies. Proc Natl Acad Sci U.S.A. 113, 9384-9387 (2016).", "F. W. Lawvere, S. H. Schanuel, Conceptual Mathematics: A First Introduction to Categories (Cambridge University Press, Cambridge, UK, 2009).", "F. W. Lawvere, \"Categories of space and of quantity\" in The Space of Mathematics: Philosophical, Epistemological and Historical Explorations, J. Echeverria, A. Ibarra, and T. Mormann, Eds. (DeGruyter, Berlin, 1992), pp. 14-30.", "S. A. Lipton, P. A. Rosenberg, Excitatory amino acids as a final common pathway for neurologic disorders. The New England Journal of Medicine 330, 613-622 (1994).", "T. D. Albright, Perceiving. Daedalus 144, 22-41 (2015).", "B. Zheng, Aggregate poverty measures. Journal of Economic Surveys 11, 123-162 (1997).", "C. Ehresmann, Trends toward unity in mathematics. Cahiers de Topologie et G\u00e9om\u00e9trie Diff\u00e9rentielle Cat\u00e9goriques 8, 1-7 (1966).", "S. Kuznets, Economic growth and income inequality. American Economic Review 45, 1-28 (1955).", "T. M. Seldon, D. Song, Environmental quality and development: Is there a Kuznets curve for air pollution emissions? Journal of Environmental Economics and Management 27, 147-28 (1994).", "B. K. Sovacool, What are we doing here? Analyzing fifteen years of energy scholarship and proposing a social science research agenda. Energy Research & Social Science 1, 1-29 (2014).", "S. Vazire, Our obsession with eminence warps research. Nature 547, 7 (2017).", "D. Sarewitz, The pressure to publish pushes down quality. Nature 533, 147 (2016).", "F. W. Lawvere, Foundations and applications: Axiomatization and education. The Bulletin of Symbolic Logic 9, 213-224 (2003)."]}
Counteracting Stereotypes and Forgiving Bad Deeds: How are Calgarian Journalists Framing the White Pride Parade?
Creators: name: Duguay, Jean-Philippe
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Social Identity
Anti Racist Action Group
Hate Groups
Journalistic Discourse
Calgary Alberta

description: Drawing on the concepts of stereotyping, cognitive consistency and intergroup relations found in Social Identity Theory the researcher analyses journalistic coverage of confrontations between white pride group and antiracist group (ARA) in Calgary and Edmonton between 2008 and 2012. The aim of the analysis is to understand how Calgary journalists are framing the annual white pride parade. The journalistic frames are analysed with the help of content analysis and are guided by two research hypotheses: 1. Journalists from Calgary (as opposed to journalists from other regions of Canada) are more forgiving of anti-racists than the white pride group because of their stereotyped driven views; 2. Journalists from Calgary (as opposed to journalists from other regions of Canada) are portraying the white pride group as outsiders to protect their community’s image.
The Study of Reactor Wall Fouling in Gas-solid Fluidized Beds Caused by Electrostatic Charge Generation
Creators: name: Sowinski, Andrew
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: Gas-Solid Fluidization
Electrostatic Charge Generation
Faraday Cup
Wall Fouling

description: Electrostatic charge generation is unavoidable in gas-solid fluidized beds due to the repeated particle-particle and particle reactor wall contacts and separations. In industrial operations such as in polyethylene production this phenomenon results in the significant problem of reactor wall fouling, known as “sheeting”. To better understand the underlying charging mechanisms involved in gas-solid fluidized beds in an attempt to eliminate and/or reduce the effect a novel on-line electrostatic charge measurement technique was developed, which concurrently provided information on both the degree of fluidized bed electrification and reactor wall fouling. A Faraday cup replaced the windbox of the fluidized bed while another cup was placed at the top of the column. The distributor plate was uniquely designed for the systematic removal of bed particles and those adhered to the column wall for their charge measurement with the bottom Faraday cup, and the charge of the entrained particles was measured by the top Faraday cup. This is the first study which allowed the charge measurement of particles in the bulk of the bed, particles adhered to the column wall, and those entrained, simultaneously. In addition, this method uniquely permitted the evaluations of the degree of reactor wall fouling under different operating conditions. An experimental program was designed to investigate the influence of bed hydrodynamics (fluidizing gas velocity and particle size), fluidization column wall material, and the addition of different solid additives. Fluidizing particles were polyethylene resin from an industrial reactor. Bi-polar charging was observed where the elutriated particles were oppositely charged compared to those in the bulk of the bed and those adhered to the column wall. Particles within the wall coating were also found to be bi-polarly charged. With the resin tested as received, a certain sized particles (350-575 µm) adhered to the column wall. The specific charge of the particles near the column wall was found not to be a definite indication of the amount of wall fouling. Increasing the gas velocity promoted wall fouling and elevated the charge density of the particles within both bubbling and slugging flow regimes. The effect of solid additive injection was examined with two static drivers known to reduce wall fouling in industrial operations, a deactivated catalyst, and the catalyst support. It was found that the catalyst promoted, while one of the static drivers reduced wall fouling.
Brief an Emanuel Bernoulli-Müller, Basler Kunstverein
Creators: name: Coutau, Hippolyte
Publisher: name: [s.n.]
Year: 1897

description: Der Brief ist an den Sekretär des Basler Kunstvereins gerichtet; 1897 hatte E. Bernoulli-Müller dieses Amt inne.
description: von Hippolyte Coutau
description: S. 2: Registraturvermerk des Basler Kunstvereins von der Hand E. Bernoullis.
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
Rubens, Bernard
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1825

description: Ort: Borghorst bei Münster
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Chinese Students’ Experience of Student-instructor Relationships at the University of Ottawa
Creators: name: Chen, Danyan
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2017
Subjects: Interpersonal Relationship
Teacher Immediacy
Rapport
Phenomenology
qualitative interviews
instructional Communication

description: Research shows that there is an increasing number of international students studying in universities and colleges in Canada, with China a top source country of international students. However, Chinese students’ experience studying in Canada has been rarely researched. Taking University of Ottawa as a case, this study explores the experience of Chinese students in terms of their relationships with instructors through a relational communication lens. Semi-structured in-depth interviews were conducted with Chinese first year students studying at the University of Ottawa to explore their experience of student-instructor relationships, to understand their overall experience of the student-instructor relationship, to identify the contributors and hindrances to the development of positive student-instructor relationships, and to explore the impact of such relationship on the students. Findings indicate that Chinese students experience different education and acculturation which influences their overall experience of student-instructor relationships. Teacher immediacy, rapport and classroom justice are factors that affect the development of such relationships, whose impact include both academic and social outcomes.
Rougemont & Behrends
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1825

description: Ort: London
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Breyeriana Orfila 1957
Creators: name: Penco, Fernando C.
name: Yakovlev, Roman V.
name: Naydenov, Artem E.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Cossidae
Breyeriana

description: Breyeriana Orfila, 1957: 124−128
 Type species: Breyeriana cistransandina Orfila, 1957
(Figs. 1, 2, 5, 8)
Illustrated specimens: paratype, male, Argentina, Neuquén, Catan-Lil, 25.i.1963, Leg. Schajovskoi (NHMUK) (Fig. 1); Argentina, Confluencia Traful, Prov. Neuquén, 13.ii.1956, leg. Fleiss (ZSM) (Figs. 2, 5)
description: Published as part of Penco, Fernando C., Yakovlev, Roman V. & Naydenov, Artem E., 2019, New species of genus Breyeriana Orfila, 1957 (Lepidoptera: Cossidae: Hypoptinae) from Argentina, pp. 114-118 in Ecologica Montenegrina 20 (2019) on page 115, DOI: 10.37828/em.2019.20.11, http://zenodo.org/record/13359938
Individual Neutrino Masses From a Supernova
Creators: name: Denton, Peter B.
name: Kini, Yves
Publisher: name: arXiv
Year: 2024
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: A nearby supernova will carry an unprecedented wealth of information about astrophysics, nuclear physics, and particle physics. Because supernova are fundamentally neutrino driven phenomenon, our knowledge about neutrinos -- particles that remain quite elusive -- will increase dramatically with such a detection. One of the biggest open questions in particle physics is related to the masses of neutrinos. Here we show how a galactic supernova provides information about the masses of each of the three mass eigenstates \emph{individually}, at some precision, and is well probed at JUNO. This information comes from several effects including time delay and the MSW effect within the supernova. The time delay feature is strongest during a sharp change in the flux such as the neutronization burst; additional information may also come from a QCD phase transition in the supernova or if the supernova forms a black hole. We consider both standard cases as dictated by local oscillation experiments as well as new physics motivated scenarios where neutrino masses may differ across the galaxy.
description: 18 pages, 13 figures, 2 tables. Comments welcome! v2: clarifying remarks and references added, matches published version
Schenck, J. C., sel. Enkel
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1825

description: Ort: Glatz
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
The Double-Ellipsoid Geometry of CLIP
Creators: name: Levi, Meir Yossef
name: Gilboa, Guy
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: Contrastive Language-Image Pre-Training (CLIP) is highly instrumental in machine learning applications within a large variety of domains. We investigate the geometry of this embedding, which is still not well understood. We examine the raw unnormalized embedding and show that text and image reside on linearly separable ellipsoid shells, not centered at the origin. We explain the benefits of having this structure, allowing to better embed instances according to their uncertainty during contrastive training. Frequent concepts in the dataset yield more false negatives, inducing greater uncertainty. A new notion of conformity is introduced, which measures the average cosine similarity of an instance to any other instance within a representative data set. We show this measure can be accurately estimated by simply computing the cosine similarity to the modality mean vector. Furthermore, we find that CLIP's modality gap optimizes the matching of the conformity distributions of image and text.
description: Accepted to ICML 2025. This version matches the camera-ready version