cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Power analysis for clustered non-continuous responses in multicenter trials
Creators: name: T. Chen
name: K. Knox
name: J. Arora
name: W. Tang
name: J. Kowalski
name: X.M. Tu
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Power analysis for multi-center randomized control trials is quite difficult to perform for non-continuous responses when site differences are modeled by random effects using the generalized linear mixed-effects model (GLMM). First, it is not possible to construct power functions analytically, because of the extreme complexity of the sampling distribution of parameter estimates. Second, Monte Carlo (MC) simulation, a popular option for estimating power for complex models, does not work within the current context because of a lack of methods and software packages that would provide reliable estimates for fitting such GLMMs. For example, even statistical packages from software giants like SAS do not provide reliable estimates at the time of writing. Another major limitation of MC simulation is the lengthy running time, especially for complex models such as GLMM, especially when estimating power for multiple scenarios of interest. We present a new approach to address such limitations. The proposed approach defines a marginal model to approximate the GLMM and estimates power without relying on MC simulation. The approach is illustrated with both real and simulated data, with the simulation study demonstrating good performance of the method.
Phytochemical analysis of non-volatile fraction of Artemisia caerulescens subsp. densiflora (Viv.) (Asteraceae), an endemic species of La Maddalena Archipelago (Sardinia – Italy)
Creators: name: Ornano, Luigi
name: Venditti, Alessandro
name: Donno, Yuri
name: Sanna, Cinzia
name: Ballero, Mauro
name: Armandodoriano Bianco
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry

description: Artemisia caerulescens subsp. densiflora Viv. is a rare endemic species from Corsica and Sardinia. We studied a sample collected from Razzoli, an island of the La Maddalena Archipelago. The polar secondary metabolites content of this species was investigated for the first time in this study showing the presence of sesquiterpenoids, flavonoids, caffeoylquinic acids and a coumarin, with the presence of several compounds already recognised in this genus. The metabolites composition was analysed in two different phenological stages, post blooming and flowering. During the blooming stage, the plant showed a molecular pattern mainly represented by sesquiterpenes and sterols with a minor amount of phenolics, while in flowering stage the molecular pattern was more rich in flavonoids and phenylpropanoids.
High-performance liquid chromatographic method for profiling 2-oxo acids in urine and its application in evaluating vitamin status in rats
Creators: name: Shibata, Katsumi
name: Chifumi Nakata
name: Fukuwatari, Tsutomu
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: Developmental Biology
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Microbiology
subject: Medicine
subject: Biochemistry
subject: Biophysics

description: B-group vitamins are involved in the catabolism of 2-oxo acids. To identify the functional biomarkers of B-group vitamins, we developed a high-performance liquid chromatographic method for profiling 2-oxo acids in urine and applied this method to urine samples from rats deficient in vitamins B1 and B6 and pantothenic acid. 2-Oxo acids were reacted with 1,2-diamino-4,5-methylenebenzene to produce fluorescent derivatives, which were then separated using a TSKgel ODS-80Ts column with 30 mmol/L of KH2PO4 (pH 3.0):acetonitrile (7:3) at a flow rate of 1.0 mL/min. Vitamin B1 deficiency increased urinary levels of all 2-oxo acids, while vitamin B6 deficiency only increased levels of sum of 2-oxaloacetic acid and pyruvic acid, and pantothenic acid deficiency only increased levels of 2-oxoisovaleric acid. Profiles of 2-oxo acids in urine samples might be a non-invasive way of clarifying the functional biomarker of B-group vitamins.
Power analysis for clustered non-continuous responses in multicenter trials
Creators: name: T. Chen
name: K. Knox
name: J. Arora
name: W. Tang
name: J. Kowalski
name: X.M. Tu
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Power analysis for multi-center randomized control trials is quite difficult to perform for non-continuous responses when site differences are modeled by random effects using the generalized linear mixed-effects model (GLMM). First, it is not possible to construct power functions analytically, because of the extreme complexity of the sampling distribution of parameter estimates. Second, Monte Carlo (MC) simulation, a popular option for estimating power for complex models, does not work within the current context because of a lack of methods and software packages that would provide reliable estimates for fitting such GLMMs. For example, even statistical packages from software giants like SAS do not provide reliable estimates at the time of writing. Another major limitation of MC simulation is the lengthy running time, especially for complex models such as GLMM, especially when estimating power for multiple scenarios of interest. We present a new approach to address such limitations. The proposed approach defines a marginal model to approximate the GLMM and estimates power without relying on MC simulation. The approach is illustrated with both real and simulated data, with the simulation study demonstrating good performance of the method.
Supplementary methods and results from The genetic basis of structural colour variation in mimetic Heliconius butterflies
Creators: name: Brien, Melanie N.
name: Romero, Juan Enciso
name: Lloyd, Victoria J.
name: Curran, Emma V.
name: Parnell, Andrew J.
name: Morochz, Carlos
name: Salazar, Patricio A.
name: Rastas, Pasi
name: Zinn, Thomas
name: Nadeau, Nicola J.
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Biophysics
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology

description: Supplementary text and supporting figures and tables giving further details of the methods, analyses and results not included in the main text
Association of orexin receptor polymorphisms with antipsychotic-induced weight gain
Creators: name: Tiwari, Arun K.
name: Brandl, Eva J.
name: Zai, Clement C.
name: Goncalves, Vanessa F.
name: Chowdhury, Nabilah I.
name: Freeman, Natalie
name: Lieberman, Jeffrey A.
name: Meltzer, Herbert Y.
name: Kennedy, James L.
name: Müller, Daniel J.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objectives: Antipsychotic-induced weight gain (AIWG) is a common side effect of treatment with antipsychotics such as clozapine and olanzapine. The orexin gene and its receptors are expressed in the hypothalamus and have been associated with maintenance of energy homeostasis. In this study, we have analysed tagging single nucleotide polymorphisms (SNPs) in orexin receptors 1 and 2 (HCRTR1 and HCRTR2) for association with AIWG. Methods: Schizophrenia or schizoaffective disorder subjects (n = 218), treated mostly with clozapine and olanzapine for up to 14 weeks, were included. Replication was conducted in a subset of CATIE samples (n = 122) treated with either olanzapine or risperidone for up to 190 days. Association between SNPs and AIWG was assessed using analysis of covariance (ANCOVA) with baseline weight and duration of treatment as covariates. Results: Several SNPs in HCRTR2 were nominally associated with AIWG in patients of European ancestry treated with either clozapine or olanzapine (P<0.05). In the replication analysis two SNPs rs3134701 (P = 0.043) and rs12662510 (P = 0.012) were nominally associated with AIWG. None of the SNPs in HCRTR1 were associated with AIWG. Conclusion: This study provides preliminary evidence supporting the role of HCRTR2 in AIWG. However, these results need to be confirmed in large study samples.
Employability in the video games industry: Matching education to the needs of the UK's games industry
Creators: name: Jones, Dr Bethan
Publisher: name: Zenodo
Year: 2024

description: The video games sector is one of the UK’s fastest-growing creative industries. In 2019 it contributed £2.8 billion to the economy and employed 27,000 people. 

The government wants to help create a million extra jobs in the creative industries by 2030, but studios say that games degrees are not producing industry-ready graduates.

Games companies need to work more closely with universities, schools and careers services to help shape education and advise on which future technologies are needed to grow the industry.

Higher education institutions should offer more support to lecturers on games-related courses.

The government needs to ensure that information about the sector, relevant skills and career opportunities are available to potential workers when they are much younger, beginning in primary education.
Spanish abstract from The genetic basis of structural colour variation in mimetic Heliconius butterflies
Creators: name: Brien, Melanie N.
name: Romero, Juan Enciso
name: Lloyd, Victoria J.
name: Curran, Emma V.
name: Parnell, Andrew J.
name: Morochz, Carlos
name: Salazar, Patricio A.
name: Rastas, Pasi
name: Zinn, Thomas
name: Nadeau, Nicola J.
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Biophysics
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology

description: Structural colours, produced by the reflection of light from ultrastructures, have evolved multiple times in butterflies. Unlike pigmentary colours and patterns, little is known about the genetic basis of these colours. Reflective structures on wing-scale ridges are responsible for iridescent structural colour in many butterflies, including the Müllerian mimics Heliconius erato and Heliconius melpomene. Here, we quantify aspects of scale ultrastructure variation and colour in crosses between iridescent and non-iridescent subspecies of both of these species and perform quantitative trait locus (QTL) mapping. We show that iridescent structural colour has a complex genetic basis in both species, with offspring from crosses having a wide variation in blue colour (both hue and brightness) and scale structure measurements. We detect two different genomic regions in each species that explain modest amounts of this variation, with a sex-linked QTL in H. erato but not H. melpomene. We also find differences between species in the relationships between structure and colour, overall suggesting that these species have followed different evolutionary trajectories in their evolution of structural colour. We then identify genes within the QTL intervals that are differentially expressed between subspecies and/or wing regions, revealing likely candidates for genes controlling structural colour formation.This article is part of the theme issue ‘Genetic basis of adaptation and speciation: from loci to causative mutations’.
Arabidopsis thaliana PRL1 is involved in low-calcium tolerance
Creators: name: SHIKANAI, Yusuke
name: YAMAGAMI, Mutsumi
name: Shigenobu, Shuji
name: Yamaguchi, Katsushi
name: KAMIYA, Takehiro
name: Fujiwara, Toru
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Computational Biology
subject: 60506 Virology
subject: FOS: Biological sciences
subject: Plant Biology
subject: Biological Sciences
subject: Ecology
subject: Earth and Environmental Sciences
subject: Genetics
subject: Cell Biology
subject: Medicine

description: Calcium (Ca) deficiency symptoms in plants often occur in agriculture; however, little is known about the mechanisms for adaptation to low-Ca conditions. To understand the mechanisms, we screened for Arabidopsis thaliana (L.) Heynh mutants sensitive to low Ca. Here, we describe one of the mutants, lcs1-1, isolated from the screen. The relative shoot growth of the mutant was reduced under the low-Ca conditions compared with the wild-type plants. Genetic mapping and genome resequencing revealed that lcs1-1 has one nonsynonymous mutation in the region of the chromosome responsible for the phenotype. The mutation is in Pleiotropic Regulatory Locus 1 (PRL1). An allelism test between lcs1-1 and a T-DNA inserted allele of prl1 demonstrates that the causal gene of lcs1-1 is PRL1. It has been reported that PRL1 is involved in sugar metabolism; however, the involvement of PRL1 in low-Ca tolerance has not been reported. Our results suggest a new insight connecting sugar metabolism with a mechanism for low-Ca tolerance in plants.
A critical review finds styrene lacks direct endocrine disruptor activity
Creators: name: Heinz-Peter Gelbke
name: Banton, Marcy
name: Leibold, Edgar
name: Pemberton, Mark
name: Samson, Susan Leanne
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Developmental Biology
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Meta Science
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Physiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biochemistry

description: The European Commission lists styrene (S) as an endocrine disruptor based primarily on reports of increased prolactin (PRL) levels in S-exposed workers. The US Environmental Protection Agency included S in its list of chemicals to be tested for endocrine activity. Therefore, the database of S for potential endocrine activity is assessed. In vitro and in vivo screening studies, as well as non-guideline and guideline investigations in experimental animals indicate that S is not associated with (anti)estrogenic, (anti)androgenic, or thyroid-modulating activity or with an endocrine activity that may be relevant for the environment. Studies in exposed workers have suggested elevated PRL levels that have been further examined in a series of human and animal investigations. While there is only one definitively known physiological function of PRL, namely stimulation of milk production, many normal stress situations may lead to elevations without any chemical exposure. Animal studies on various aspects of dopamine (DA), the PRL-regulating neurotransmitter, in the central nervous system did not give mechanistic explanations on how S may affect PRL levels. Overall, a neuroendocrine disruption of PRL regulation cannot be deduced from a large experimental database. The effects in workers could not consistently be reproduced in experimental animals and the findings in humans represented acute reversible effects clearly below clinical and pathological levels. Therefore, unspecific acute workplace-related stress is proposed as an alternative mode of action for elevated PRL levels in workers.
Supplementary Figures and Tables from The genetic basis of structural colour variation in mimetic Heliconius butterflies
Creators: name: Brien, Melanie N.
name: Romero, Juan Enciso
name: Lloyd, Victoria J.
name: Curran, Emma V.
name: Parnell, Andrew J.
name: Morochz, Carlos
name: Salazar, Patricio A.
name: Rastas, Pasi
name: Zinn, Thomas
name: Nadeau, Nicola J.
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Biophysics
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology

description: All supplementary figures and tables referred to in the main text (except tables S5-S12 inclusive, which are provided as separate Excel files)
Modulares Support-Toolkit für Lehrkräfte
Creators: name: Scheuer, Claude
name: Heck, Sandra
Publisher: name: Zenodo
Year: 2020
Subjects: motor competence
support toolkit
children
teacher
promotion
assessment

description: Im Rahmen des BMC-EU-Projekts (Motorische Basiskompetenzen in Europa) wurden ein Unterstützungsrahmen und ein modulares Unterstützungs-Toolkit auf der Grundlage des Konzepts der grundlegenden motorischen Kompetenzen und der Ergebnisse der Datenerfassung in Phase 1 des Projekts als Teil des intellektuellen Outputs 3entwickelt. Ziel dieses Toolkits ist es, hauptsächlich auf der Ebene des regulären Sportunterrichts umgesetzt zu werden, um Anpassungen hinsichtlich der Inhalte und Methoden des Sportunterrichts einzuleiten.
 In einem ersten Schritt wurde der Unterstützungsrahmen entwickelt, um von der Diagnose der grundlegenden motorischen Kompetenzen der Schülerinnen und Schüler1 und der in der Bewertung identifizierten Stärken und Schwächen zu konkreten Interventionen zu gelangen. Basierend auf diesem Rahmen wurden unterstützende Handouts in Form eines modularen Support-Toolkits entwickelt, die in konkreten Bildungssituationen implementiert werden können, um Schüler mit zusätzlichen Anforderungen an motorische Basiskompetenzen zu unterstützen.
 Das modulare Support-Toolkit enthält Richtlinien für die Interpretation der Testergebnisse von MOBAK (Motorische Basiskompetenzen), das MOBAK-Unterstützungsrahmen, ein Glossar sowie das modulare Support-Toolkit mit Materialien für Sportlehrer in Form von MOBAK Aufgabenbeschreibungskarten und MOBAK-Aktivitätskarten basierend auf Variationsprinzipien und einem kompetenzorientierten Ansatz.
description: Project "Basic Motor Competencies in Europe – Assessment and Promotion" (BMC-EU); Funder: European Commission - Erasmus+ Programme of the European Union; Programme: Erasmus+ Sport: Collaborative Partnerships - 2017; Reference: 590777-EPP-1-2017-1-DE-SPO-SCP; Timeline: January 2018 - December 2019; Project Sheet: https://ec.europa.eu/programmes/erasmus-plus/projects/eplus-project-details/#project/590777-EPP-1-2017-1-DE-SPO-SCP
S = O…S = O Interactions as a Driving Force for Low-Temperature Conformational Rearrangement of Stable H-bonding in the {S(O)-CH2-CH2-OH…}2 Synthon; Two Modifications of Diastereomeric Pinanyl Sulfoxides in a Co-Crystal
Creators: name: Lodochnikova, Olga A.
name: Krivolapov, Dmitry B.
name: Startseva, Valeriya A.
name: Nikitina, Liliya E.
name: Bodrov, Andrei V.
name: Artemova, Nadezhda P.
name: Klochkov, Vladimir V.
name: Madzhidov, Timur I.
name: Chmutova, Galina A.
name: Litvinov, Igor A.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology
subject: Physics
subject: Biochemistry
subject: Biophysics

description: For the triclinic and monoclinic modifications of a diastereomeric pinanyl sulfoxide co-crystal, a remarkable alterations of unit cell parameters by transition from 293 К to 150 К was ascertained. Such alterations are accompanied by conformational restructuring of a stable hydrogen-bonded synthon from an “unfolded” to a “folded” form. The driving force of this restructuring is the tendency to form S = O…S = O interactions, which show up in the low-temperature phases of both polymorphs. These are well-supported by the methods of quantum chemistry (DFT, B97-D/6-31G(d,p), AIM All).
The importance of distribution-choice in modeling substance use data: a comparison of negative binomial, beta binomial, and zero-inflated distributions
Creators: name: Wagner, Brandie
name: Riggs, Paula
name: Mikulich-Gilbertson, Susan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences
subject: Biotechnology

description: Background: It is important to correctly understand the associations among addiction to multiple drugs and between co-occurring substance use and psychiatric disorders. Substance-specific outcomes (e.g. number of days used cannabis) have distributional characteristics which range widely depending on the substance and the sample being evaluated. Objectives: We recommend a four-part strategy for determining the appropriate distribution for modeling substance use data. We demonstrate this strategy by comparing the model fit and resulting inferences from applying four different distributions to model use of substances that range greatly in the prevalence and frequency of their use. Methods: Using Timeline Followback (TLFB) data from a previously-published study, we used negative binomial, beta-binomial and their zero-inflated counterparts to model proportion of days during treatment of cannabis, cigarettes, alcohol, and opioid use. The fit for each distribution was evaluated with statistical model selection criteria, visual plots and a comparison of the resulting inferences. Results: We demonstrate the feasibility and utility of modeling each substance individually and show that no single distribution provides the best fit for all substances. Inferences regarding use of each substance and associations with important clinical variables were not consistent across models and differed by substance. Conclusion: Thus, the distribution chosen for modeling substance use must be carefully selected and evaluated because it may impact the resulting conclusions. Furthermore, the common procedure of aggregating use across different substances may not be ideal.
massenet_procb_ESM from Nonlinear vocal phenomena affect human perceptions of distress, size and dominance in puppy whines
Creators: name: Massenet, Mathilde
name: Anikin, Andrey
name: Pisanski, Katarzyna
name: Reynaud, Karine
name: Mathevon, Nicolas
name: Reby, David
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: 60801 Animal Behaviour
subject: FOS: Biological sciences

description: Supplementary materials presenting acoustic analysis and results from Experiment 3
State of the field: An informatics-based systematic review of the SOD1-G93A amyotrophic lateral sclerosis transgenic mouse model
Creators: name: Renaid B. Kim
name: Irvin, Cameron W.
name: Keval R. Tilva
name: Mitchell, Cassie S.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Neuroscience
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Numerous sub-cellular through system-level disturbances have been identified in over 1300 articles examining the superoxide dismutase-1 guanine 93 to alanine (SOD1-G93A) transgenic mouse amyotrophic lateral sclerosis (ALS) pathophysiology. Manual assessment of such a broad literature base is daunting. We performed a comprehensive informatics-based systematic review or ‘field analysis’ to agnostically compute and map the current state of the field. Text mining of recaptured articles was used to quantify published data topic breadth and frequency. We constructed a nine-category pathophysiological function-based ontology to systematically organize and quantify the field's primary data. Results demonstrated that the distribution of primary research belonging to each category is: systemic measures an motor function, 59%; inflammation, 46%; cellular energetics, 37%; proteomics, 31%; neural excitability, 22%; apoptosis, 20%; oxidative stress, 18%; aberrant cellular chemistry, 14%; axonal transport, 10%. We constructed a SOD1-G93A field map that visually illustrates and categorizes the 85% most frequently assessed sub-topics. Finally, we present the literature-cited significance of frequently published terms and uncover thinly investigated areas. In conclusion, most articles individually examine at least two categories, which is indicative of the numerous underlying pathophysiological interrelationships. An essential future path is examination of cross-category pathophysiological interrelationships and their co-correspondence to homeostatic regulation and disease progression.
State of the field: An informatics-based systematic review of the SOD1-G93A amyotrophic lateral sclerosis transgenic mouse model
Creators: name: Renaid B. Kim
name: Irvin, Cameron W.
name: Keval R. Tilva
name: Mitchell, Cassie S.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Neuroscience
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Numerous sub-cellular through system-level disturbances have been identified in over 1300 articles examining the superoxide dismutase-1 guanine 93 to alanine (SOD1-G93A) transgenic mouse amyotrophic lateral sclerosis (ALS) pathophysiology. Manual assessment of such a broad literature base is daunting. We performed a comprehensive informatics-based systematic review or ‘field analysis’ to agnostically compute and map the current state of the field. Text mining of recaptured articles was used to quantify published data topic breadth and frequency. We constructed a nine-category pathophysiological function-based ontology to systematically organize and quantify the field's primary data. Results demonstrated that the distribution of primary research belonging to each category is: systemic measures an motor function, 59%; inflammation, 46%; cellular energetics, 37%; proteomics, 31%; neural excitability, 22%; apoptosis, 20%; oxidative stress, 18%; aberrant cellular chemistry, 14%; axonal transport, 10%. We constructed a SOD1-G93A field map that visually illustrates and categorizes the 85% most frequently assessed sub-topics. Finally, we present the literature-cited significance of frequently published terms and uncover thinly investigated areas. In conclusion, most articles individually examine at least two categories, which is indicative of the numerous underlying pathophysiological interrelationships. An essential future path is examination of cross-category pathophysiological interrelationships and their co-correspondence to homeostatic regulation and disease progression.
Boletín sobre Ruido Ambiental
Creators: name: Pineda Pardo, Leonardo Alfredo
name: Hernández Hernández, Ana María
name: Guerrero Molina, Oscar Julián
name: Cabeza Alarcón, María del Carmen
name: Guerrero Sánchez, Lina Marcela
name: Espinosa Velásquez, Johanna Alexandra
name: Instituto de Hidrología, Meteorología y Estudios Ambientales - IDEAM
name: Ministerio de Ambiente y Desarrollo Sostenible
name: Ministerio de Salud y Protección Social
Publisher: name: Zenodo
Year: 2017

description: El documento aborda el contexto conceptual y normativo para prevenir problemáticas ocasionadas por ruido ambiental en Colombia
Two distinct phenotypes of asthma in elite athletes identified by latent class analysis
Creators: name: Severo, Milton
name: Mowinckel, Petter
name: Moreira, André
name: Kai-Håkon Carlsen
name: Couto, Mariana
name: Stang, Julie
name: Horta, Luís
name: Stensrud, Trine
name: Silva, Diana
name: Delgado, Luís
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Science Policy
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Earth and Environmental Sciences
subject: Genetics
subject: Medicine

description: Introduction: Clusters of asthma in athletes have been insufficiently studied. Therefore, the present study aimed to characterize asthma phenotypes in elite athletes using latent class analysis (LCA) and to evaluate its association with the type of sport practiced. Methods: In the present cross-sectional study, an analysis of athletes’ records was carried out in databases of the Portuguese National Anti-Doping Committee and the Norwegian School of Sport Sciences. Athletes with asthma, diagnosed according to criteria given by the International Olympic Committee, were included for LCA. Sports practiced were categorized into water, winter and other sports. Results: Of 324 files screened, 150 files belonged to asthmatic athletes (91 Portuguese; 59 Norwegian). LCA retrieved two clusters: “atopic asthma” defined by allergic sensitization, rhinitis and allergic co-morbidities and increased exhaled nitric oxide levels; and “sports asthma”, defined by exercise-induced respiratory symptoms and airway hyperesponsiveness without allergic features. The risk of developing the phenotype “sports asthma” was significantly increased in athletes practicing water (OR = 2.87; 95%CI [1.82–4.51]) and winter (OR = 8.65; 95%CI [2.67–28.03]) sports, when compared with other athletes. Conclusion: Two asthma phenotypes were identified in elite athletes: “atopic asthma” and “sports asthma”. The type of sport practiced was associated with different phenotypes: water and winter sport athletes had three- and ninefold increased risk of “sports asthma”. Recognizing different phenotypes is clinically relevant as it would lead to distinct targeted treatments.
2-year follow-up report on micromotion of a short tibia stem
Creators: name: Molt, Mats
name: Toksvig-Larsen, Sören
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Developmental Biology
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Physiology
subject: Cell Biology
subject: Medicine
subject: Biochemistry

description: Background and purpose — A shortened tibial stem could influence the early prosthetic fixation. We therefore compared the short stem to the standard-length stem using radiostereometric analysis (RSA) as primary outcome measure.Patients and methods — 60 patients were randomized to receive a cemented Triathlon total knee arthroplasty (TKA) with a tibial tray of either standard or short stem length. The patients were blinded regarding treatment allocation. The micromotion of the tibial component was measured by RSA postoperatively, at 3 months, and after 1 and 2 years; clinical outcome was measured with the American Knee Society score (AKSS) and the knee osteoarthritis and injury outcome score (KOOS).Results — The maximum total point motion (MTPM) for the standard stem was 0.36 (SD 0.16) mm at 3 months, 0.51 (SD 0.27) mm at 1 year, and 0.54 (SD 0.28) mm at 2 years. For the short stem, it was 0.42 (0.24) mm, 0.59 (0.43) mm, and 0.61 (0.39) mm. 4 short-stemmed components and 2 standard-stemmed components had more than 0.2 mm of migration between the first- and second-year follow-up, and were classified as continuously migrating.Interpretation — The short-stemmed cemented tibial prosthesis showed an early prosthetic migratory pattern similar to that of the standard-stemmed cemented Triathlon knee prosthesis. The number of continuously migrating tibial plates in each group is predictive of a lower revision rate than 5% at 10 years.
S = O…S = O Interactions as a Driving Force for Low-Temperature Conformational Rearrangement of Stable H-bonding in the {S(O)-CH2-CH2-OH…}2 Synthon; Two Modifications of Diastereomeric Pinanyl Sulfoxides in a Co-Crys
Creators: name: Lodochnikova, Olga A.
name: Krivolapov, Dmitry B.
name: Startseva, Valeriya A.
name: Nikitina, Liliya E.
name: Bodrov, Andrei V.
name: Artemova, Nadezhda P.
name: Klochkov, Vladimir V.
name: Madzhidov, Timur I.
name: Chmutova, Galina A.
name: Litvinov, Igor A.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology
subject: Physics
subject: Biochemistry
subject: Biophysics

description: For the triclinic and monoclinic modifications of a diastereomeric pinanyl sulfoxide co-crystal, a remarkable alterations of unit cell parameters by transition from 293 К to 150 К was ascertained. Such alterations are accompanied by conformational restructuring of a stable hydrogen-bonded synthon from an “unfolded” to a “folded” form. The driving force of this restructuring is the tendency to form S = O…S = O interactions, which show up in the low-temperature phases of both polymorphs. These are well-supported by the methods of quantum chemistry (DFT, B97-D/6-31G(d,p), AIM All).
Precision of radiostereometric analysis (RSA) of acetabular cup stability and polyethylene wear improved by adding tantalum beads to the liner
Creators: name: Nebergall, Audrey K
name: Rader, Kevin
name: Palm, Henrik
name: Malchau, Henrik
name: Meridith E Greene
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Chemistry
Earth and Environmental Sciences
Biotechnology
Molecular Biology
Cell Biology
Medicine
Engineering

description: Background and purpose — In traditional radiostereometric analysis (RSA), 1 segment defines both the acetabular shell and the polyethylene liner. However, inserting beads into the polyethylene liner permits employment of the shell and liner as 2 separate segments, enabling distinct analysis of the precision of 3 measurement methods in determining femoral head penetration and shell migration.Patients and methods — The UmRSA program was used to analyze the double examinations of 51 hips to determine if there was a difference in using the shell-only segment, the liner-only segment, or the shell + liner segment to measure wear and acetabular cup stability. The standard deviation multiplied by the critical value (from a t distribution) established the precision of each method.Results — Due to the imprecision of the automated edge detection, the shell-only method was least desirable. The shell + liner and liner-only methods had a precision of 0.115 mm and 0.086 mm, respectively, when measuring head penetration. For shell migration, the shell + liner had a precision of 0.108 mm, which was better than the precision of the shell-only method. In both the penetration and migration analyses, the shell + liner condition number was statistically significantly lower and the bead count was significantly higher than for the other methods.Interpretation — Insertion of beads in the polyethylene improves the precision of femoral head penetration and shell migration measurements. A greater dispersion and number of beads when combining the liner with the shell generated more reliable results in both analyses, by engaging a larger portion of the radiograph.
Early subsidence of shape-closed hip arthroplasty stems is associated with late revision
Creators: name: Voort, Paul Van Der
name: Pijls, Bart G
name: Nieuwenhuijse, Marc J
name: Jasper, Jorrit
name: Fiocco, Marta
name: Plevier, Josepha W M
name: Middeldorp, Saskia
name: Valstar, Edward R
name: Nelissen, Rob G H H
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Chemistry
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Medicine

description: Background and purpose — Few studies have addressed the association between early migration of femoral stems and late aseptic revision in total hip arthroplasty. We performed a meta-regression analysis on 2 parallel systematic reviews and meta-analyses to determine the association between early migration and late aseptic revision of femoral stems.Patients and methods — Of the 2 reviews, one covered early migration data obtained from radiostereometric analysis (RSA) studies and the other covered long-term aseptic revision rates obtained from survival studies with endpoint revision for aseptic loosening. Stems were stratified according to the design concept: cemented shape-closed, cemented force-closed, and uncemented. A weighted regression model was used to assess the association between early migration and late aseptic revision, and to correct for confounders. Thresholds for acceptable and unacceptable migration were determined in accordance with the national joint registries (≤ 5% revision at 10 years) and the NICE criteria (≤ 10% revision at 10 years).Results — 24 studies (731 stems) were included in the RSA review and 56 studies (20,599 stems) were included in the survival analysis review. Combining both reviews for the 3 design concepts showed that for every 0.1-mm increase in 2-year subsidence, as measured with RSA, there was a 4% increase in revision rate for the shape-closed stem designs. This association remained after correction for age, sex, diagnosis, hospital type, continent, and study quality. The threshold for acceptable migration of shape-closed designs was defined at 0.15 mm; stems subsiding less than 0.15 mm in 2 years had revision rates of less than 5% at 10 years, while stems exceeding 0.15 mm subsidence had revision rates of more than 5%.Interpretation — There was a clinically relevant association between early subsidence of shape-closed femoral stems and late revision for aseptic loosening. This association can be used to assess the safety of shape-closed stem designs. The published research is not sufficient to allow us to make any conclusions regarding such an association for the force-closed and uncemented stems.
Data and scripts for article "Estimation of colour volumes as concave hypervolumes using alphashapes"
Creators: name: Gruson, Hugo
Publisher: name: Zenodo
Year: 2020
Subjects: α-shapes, Colour volume, Colourfulness, Concave Hull, Convex Hull, Hypervolumes, Functional Richness, Morphospace

description: Script and data to reproduce all results and figures from article "Estimation of colour volumes as concave hypervolumes using alphashapes"
A Deep Learning-Augmented Stand-off Radar Scheme for Rapidly Detecting Tree Defects
Creators: name: Qian, Jiwei
name: Lee, Yee Hui
name: Cheng, Kaixuan
name: Dai, Qiqi
name: Yusof, Mohamed Lokman Mohd
name: Lee, Daryl
name: Yucel, Abdulkadir C.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Signal Processing (eess.SP)
subject: Image and Video Processing (eess.IV)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Tree defect detection is crucial for the structural health screening of trees. Existing nondestructive testing (NDT) techniques for tree defect detection require time-consuming and labor-intensive measurement campaigns. This discourages their application for the routine structural health screening of whole populations of managed urban trees. To address this issue, this study proposes a deep-learning augmented stand-off radar scheme for contactless scanning of tree trunks and rapid detection of tree defects. In this scheme, the antenna is moved along a straight trajectory at a distance from the tree trunk to obtain the trunk's B-scan. The obtained raw B-scan is then processed by a signal-processing framework specifically developed for revealing the scattering signatures of defects in B-scan, which achieves a 30 dB and 22 dB increase in the signal-to-clutter and noise ratio of the measurement data of tree trunk samples and living trees, respectively. Finally, the processed B-scan is input into a multilevel feature fusion neural network particularly designed for extracting the signature of the defect in the processed B-scan in real time. The developed scheme's applications to the detection of defects in real fresh-cut tree trunks show that the stand-off radar scheme can detect tree defects with 96% accuracy. This stand-off radar scheme is the first contactless NDT technique for tree defect detection while operated on a straight trajectory and potentially can be integrated into the routine tree inspection workflow which is part of urban tree management.
description: Accepted and to be published in IEEE Transactions on Geoscience and Remote Sensing
IN03191 Rāssahela Rock Inscription 2
Creators: name: Paranavitana, S.
Publisher: name: Zenodo
Year: 2020
Subjects: IN03191
Epigraphia Zeylanica
Rajagala
Rāssahela

description: IN03191 Rāssahela Rock Inscription 2 - Transcript and Translation Source: Paranavitana, S. (1934–41). ‘No. 20. Three Rock-Inscriptions at Rāssahela,’ Epigraphia Zeylanica 4, pp. 169–176.
In vitro characterization of 4′-(p-toluenesulfonylamide)-4-hydroxychalcone using human liver microsomes and recombinant cytochrome P450s
Creators: name: Boram Lee
name: Zhexue Wu
name: Taeho Lee
name: Tan, Xue Fei
name: Park, Ki Hun
name: Kwang-Hyeon Liu
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Inorganic Chemistry

description: 1. 4′-(p-Toluenesulfonylamide)-4-hydroxychalcone (TSAHC) is a synthetic sulfonylamino chalcone compound possessing anti-cancer properties. The aim of this study was to elucidate the metabolism of TSAHC in human liver microsomes (HLMs) and to characterize the cytochrome P450 (P450) enzymes that are involved in the metabolism of TSAHC. 2. TSAHC was incubated with HLMs or recombinant P450 isoforms (rP450) in the presence of an nicotinamide adenine dinucleotide phosphate, reduced form (NADPH)-regenerating system. The metabolites were identified and analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). P450 isoforms, responsible for TSAHC metabolite formation, were characterized by chemical inhibition and correlation studies in HLMs and enzyme kinetic studies with a panel of rP450 isoforms. 3. Two hydroxyl metabolites, that is M1 and M2, were produced from the human liver microsomal incubations (Km and Vmax values were 2.46 µM and 85.1 pmol/min/mg protein for M1 and 9.98 µM and 32.1 pmol/min/mg protein for M2, respectively). The specific P450 isoforms responsible for two hydroxy-TSAHC formations were identified using a combination of chemical inhibition, correlation analysis and metabolism by expressed recombinant P450 isoforms. The known P450 enzyme activities and the rate of TSAHC metabolite formation in the 15 HLMs showed that TSAHC metabolism is correlated with CYP2C and CYP3A activity. The P450 isoform-selective inhibition study in HLMs and the incubation study of cDNA-expressed enzymes also showed that two hydroxyl metabolites M1 and M2 biotransformed from TSAHC are mainly mediated by CYP2C and CYP3A, respectively. These findings suggest that CYP2C8, CYP2C9, CYP2C19, CYP3A4 and CYP3A5 isoforms are major enzymes contributing to TSAHC metabolism.
DNA barcoding using skin exuviates can improve identification and biodiversity studies of snakes
Creators: name: Sharma, Rashmi
name: Tetsuzan Benny Ron
name: Haymer, David
name: Trupti Khedkar
name: Tiknaik, Anita
name: Khedkar, Gulab
name: Bhagwat S. Naikwade
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences
subject: Molecular Biology
subject: Genetics
subject: Microbiology

description: Snakes represent a taxonomically underdeveloped group of animals in India with a lack of experts and incomplete taxonomic descriptions being the main deterrents to advances in this area. Molecular taxonomic approaches using DNA barcoding could aid in snake identification as well as studies of biodiversity. Here a non-invasive sampling method using DNA barcoding is tested using skin exuviates. Taxonomically authenticated samples were collected and tested for validation and comparisons to unknown snake exuviate samples. This approach was also used to construct the first comprehensive study targeting the snake species from Maharashtra state in India. A total of 92 skin exuviate samples were collected and tested for this study. Of these, 81 samples were successfully DNA barcoded and compared with unknown samples for assignment of taxonomic identity. Good quality DNA was obtained irrespective of age and quality of the exuviate material, and all unknown samples were successfully identified. A total of 23 species of snakes were identified, six of which were in the list of Endangered species (Red Data Book). Intra- and inter-specific distance values were also calculated, and these were sufficient to allow discrimination among species and between species without ambiguity in most cases. Two samples were suspected to represent cryptic species based on deep K2P divergence values (>3%), and one sample could be identified to the genus level only. Eleven samples failed to amplify COI sequences, suggesting the need for alternative PCR primer pairs. This study clearly documents how snake skin exuviates can be used for DNA barcoding, estimates of diversity and population genetic structuring in a noninvasive manner.
A Knowledge Translation-Integrated Approach Evaluating the DREAM Program’s Webisodes and French Translation
Creators: name: Potter, Catherine
Publisher: name: Université Saint-Paul / Saint Paul University
Year: 2022
Subjects: psychoeducation, mental health, children, meaning mindset, covid-19, social emotional literacy

description: The adverse effects of the COVID-19 lockdowns have led to mental health challenges in nearly three-quarters of Canadian children and youth. In this pilot evaluability assessment, we used a Knowledge Translation-Integrated approach to evaluate the credibility, acceptability, and sustainability of the school-based DREAM program at increasing resilience among children ages 7 to 11. Specifically, we assessed newly produced webisodes (meant to ease teacher administration) and the French translation of the program for the first time. Credibility was supported using quantitative measures for meaning mindset, mental illness symptoms, and COVID-19 coping. Knowledge users, in this case children and parents, were involved in measuring the DREAM program’s acceptability and sustainability qualitatively and quantitatively. Data was collected from 33 children, and 31 of their parents, who completed the program and the pre- and post-test questionnaires. The webisodes were found to be credible and acceptable to the children, and produced equivalent self-reported outcomes to the clinician-delivered classes at increasing meaning mindset, decreasing mental illness symptoms, and increasing COVID-19 coping. The French version of the program also produced equivalent self-reported outcomes to the English version at increasing meaning mindset, decreasing mental illness symptoms, and increasing COVID-19 coping. Validations and suggestions for the program were coded, grouped into themes, and analyzed. A discussion of the analyses is presented, including limitations and recommendations for future directions for further development of the DREAM program.
IN03190 Rāssahela Rock Inscription 1
Creators: name: Paranavitana, S.
Publisher: name: Zenodo
Year: 2020
Subjects: IN03190
Epigraphia Zeylanica
Rāssahela
Rajagala

description: IN03190 Rāssahela Rock Inscription 1 - Transcript and Translation Source: Paranavitana, S. (1934–41). ‘No. 20. Three Rock-Inscriptions at Rāssahela,’ Epigraphia Zeylanica 4, pp. 169–176.