cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Regulatory T Cells and the Risk of CMV End-Organ Disease in Patients With AIDS
Creators: name: Bosch, Ronald
name: Weinberg, Adriana
name: Jacobson, Mark A.
name: Collier, Ann C.
name: Erice, Alejo
name: Polsky, Bruce
name: Gulick, Roy M.
name: Tovar-Salazar, Adriana
name: Benson, Constance A.
name: Bennett, Kara
name: Zolopa, Andrew
name: Wohl, David
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Cytomegalovirus (CMV)-specific T-cell effectors (CMV-Teff) protect against CMV end-organ disease (EOD). In HIV-infected individuals, their numbers and function vary with CD4+ cell numbers and HIV load. The role of regulatory T cells (Treg) in CMV-EOD has not been extensively studied. We investigated the contribution of Treg and Teff towards CMV-EOD in HIV-infected individuals independently of CD4+ cell numbers and HIV load and controlling for CMV reactivations.
The Development Of Novel Bio-based Polymeric Materials For Insulating Foams
Creators: name: Berrow, Stuart
Publisher: name: Lancaster University
Year: 2022

description: This thesis details the synthesis of a series of novel thermosetting resins incorporating bio-based raw materials, with a view to their application to produce insulating foams. The work focuses primarily on phenolic resins/foams, and herein is reported a novel method for the synthesis of phenolic resin analogues. This method was employed in the synthesis of five novel thermosetting resins, which were formaldehyde-free and produced (partly) from bio-based raw materials. Initial investigations focused on the use of glyoxylic acid as a bio-based formaldehyde replacement in phenolic resin production. The properties of the resin obtained could be easily tailored to yield resins suitable for a variety of applications, including foaming. This resin was then blended with a phenolic resin to produce novel foams, which showed promising properties for application to insulating foams. Research then focused on the use of cardanol as a bio-based phenol for phenolic resin production, with a view to improving the mechanical properties of the resulting phenolic foams. The novel method was employed to produce four novel resins consisting of condensation products of cardanol and naturally occurring aldehydes. These resins could be cured to yield flexible polymers. However, the curing of these resins was poor, taking multiple days at elevated temperature to produce the thermoset polymers, making foaming difficult. The focus of the investigations then adjusted, to focus on a cardanol-formaldehyde resin, which exhibits superior curing to the novel resins. The first reports of foam production from cardanol-formaldehyde resins are then presented. Additionally, the incorporation of a series of aromatic species based on succinic acid into thermosetting resins is discussed. These investigations focused on phenolic resins and epoxy resins, the latter proving most successful.
STI Patients Are Effective Recruiters of Undiagnosed Cases of HIV: Results of a Social Contact Recruitment Study in Malawi
Creators: name: Ward, Michelle
name: Martinson, Francis
name: Miller, William C.
name: Rosenberg, Nora E.
name: Hoffman, Irving F.
name: Kamanga, Gift
name: Pettifor, Audrey E.
name: Mapanje, Clement
name: Rutstein, Sarah E.
name: Bonongwe, Naomi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Patients with newly diagnosed HIV may be part of social networks with elevated prevalence of undiagnosed HIV infection. Social network recruitment by persons with newly diagnosed HIV may efficiently identify undiagnosed cases of HIV infection. We assessed social network recruitment as a strategy for identifying undiagnosed cases of HIV infection.
Is the Contralateral Delay Activity (CDA) a robust neural correlate for Visual Working Memory (VWM) tasks? A reproducibility study
Creators: name: Roy, Yannick
name: Faubert, Jocelyn
Publisher: name: arXiv
Year: 2022
Subjects: subject: Neurons and Cognition (q-bio.NC)
subject: FOS: Biological sciences

description: Visual working memory (VWM) allows us to actively store, update and manipulate visual information surrounding us. While the underlying neural mechanisms of VWM remain unclear, contralateral delay activity (CDA), a sustained negativity over the hemisphere contralateral to the positions of visual items to be remembered, is often used to study VWM. To investigate if the CDA is a robust neural correlate for VWM tasks, we reproduced eight CDA-related studies with a publicly accessible EEG dataset. We used the raw EEG data from these eight studies and analyzed all of them with the same basic pipeline to extract CDA. We were able to reproduce the results from all the studies and show that with a basic automated EEG pipeline we can extract a clear CDA signal. We share insights from the trends observed across the studies and raise some questions about the CDA decay and the CDA during the recall phase, which surprisingly, none of the eight studies did address. Finally, we also provide reproducibility recommendations based on our experience and challenges in reproducing these studies.
Controlling atomic spin-mixing via multiphoton transitions in a cavity
Creators: name: Xue, Ming
name: Li, Xiangliang
name: Ye, Wenhao
name: Chen, Jun-Jie
name: Xu, Zhi-Fang
name: You, Li
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We propose to control spin-mixing dynamics in a gas of spinor atoms, via the combination of two off-resonant Raman transition pathways, enabled by a common cavity mode and a bichromatic pump laser. The mixing rate, which is proportional to the synthesized spin-exchange interaction strength, and the effective atomic quadratic Zeeman shift (QZS), can both be tuned by changing the pump laser parameters. Quench and driving dynamics of the atomic collective spin are shown to be controllable on a faster time scale than in existing experiments based on inherent spin-exchange collision interactions. The results we present open a promising avenue for exploring spin-mixing physics of atomic ensembles accessible in current experiments.
description: 4.5pages with appendices, 3 figures
title: Dr. phil. h.c., Dr. rer. pol. h.c. Friedrich Zollinger, 1858-1931
title: Friedrich Zollinger, 1858-1931
titleType: AlternativeTitle
title: Erinnerungsschrift an einen bedeutenden Schulmann aus dem ersten Drittel unseres Jahrhunderts
titleType: Subtitle
title: Erster Zunftmeister der Zunft zu Hottingen 1897-1905, Ehrenzunftmeister 1922-1931
titleType: Subtitle
Creators: name: Brunner, John
name: Kull-Sprenger, Eugen
Publisher: name: Zunft Hottingen
Year: 1972
Subjects: subject: 920 Biografien, Genealogie, Insignien
subject: Nachruf
subject: Zollinger, Friedrich
subject: Nänikon
subject: Schule

description: Verfasst von a.-Zunftmeister Dr. John Brunner in Zusammenarbeit mit a.-Statthalter Eugen Kull-Sprenger anlässlich des 75. Jubiläums der Zunft Hottingen 1972.
description: Enthält: Einleitung ; Lebenslauf ; Das literarische Werk von Dr. Friedrich Zollinger ; Die Trauerfeier.
Flowfield prediction of airfoil off-design conditions based on a modified variational autoencoder
Creators: name: Yang, Yunjia
name: Li, Runze
name: Zhang, Yufei
name: Chen, Haixin
Publisher: name: arXiv
Year: 2022
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: Airfoil aerodynamic optimization based on single-point design may lead to poor off-design behaviors. Multipoint optimization that considers the off-design flow conditions is usually applied to improve the robustness and expand the flight envelope. Many deep learning models have been utilized for the rapid prediction or reconstruction of flowfields. However, the flowfield reconstruction accuracy may be insufficient for cruise efficiency optimization, and the model generalization ability is also questionable when facing airfoils different from the airfoils with which the model has been trained. Because a computational fluid dynamic evaluation of the cruise condition is usually necessary and affordable in industrial design, a novel deep learning framework is proposed to utilize the cruise flowfield as a prior reference for the off-design condition prediction. A prior variational autoencoder is developed to extract features from the cruise flowfield and to generate new flowfields under other free stream conditions. Physical-based loss functions based on aerodynamic force and conservation of mass are derived to minimize the prediction error of the flowfield reconstruction. The results demonstrate that the proposed model can reduce the prediction error on test airfoils by 30% compared to traditional models. The physical-based loss function can further reduce the prediction error by 4%. The proposed model illustrates a better balance of the time cost and the fidelity requirements of evaluation for cruise and off-design conditions, which makes the model more feasible for industrial applications.
Mapping potentially groundwater-dependent vegetation in the Mediterranean biome using global geodata targeting site conditions and vegetation characteristics
Creators: name: El-Hokayem, Léonard
name: Vita, Pantaleone
name: Usman, Muhammad
name: Link, Andreas
name: Conrad, Christopher
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 554

description: Groundwater-dependent vegetation (GDV) is essential for maintaining ecosystem functions and services, providing critical habitat for species, and sustaining human livelihoods. However, climate and land-use change are threatening GDV, highlighting the need for harmonised, global mapping of the distribution and extent of GDV. This need is particularly crucial in vulnerable biodiversity hotspots such as the Mediterranean biome. This study presents a novel multicriteria index to identify areas in the Mediterranean biome that provide suitable environmental conditions to support potentially groundwater-dependent vegetation (pGDV) where vegetation behaviour is also indicative of groundwater use. Global datasets targeting 1) groundwater vegetation interaction; 2) soil water holding capacity; 3) topographical landscape wetness potential; 4) land use land cover and 5) hydraulic conductivity of rocks have been combined for the first time in an easy-to-use index. Layer weightings from Analytical Hierarchy Process and Random Forest showed limited applicability on biome scale, but an unweighted overlay of eleven thematic layers produced plausible results. The final pGDV map indicates that 31 % of the natural vegetation in the Mediterranean biome likely depend on groundwater. Moreover, moderate to good agreement was found compared to actual GDV locations in Campania, Italy (91 % with at least moderate potential) and California, USA (87 % with at least moderate potential). The results provide valuable information for identifying regions with a substantial presence of pGDV in the Mediterranean biome and can be used for decision making, e.g. to prioritise field surveys and high-resolution remote sensing for GDV mapping. It can therefore support effective groundwater resource management and the conservation of biodiversity hotspots.
On the bundle of null cones
Creators: name: Bruce, Andrew James
Publisher: name: arXiv
Year: 2022
Subjects: subject: Differential Geometry (math.DG)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 20N10, 53B30, 53C50, 58A32, 83C99

description: We examine the bundle structure of the field of nowhere vanishing null vector fields on a (time-oriented) Lorentzian manifold. Sections of what we refer to as the null tangent, are by definition nowhere vanishing null vector fields. It is shown that the set of nowhere vanishing null vector fields comes equipped with a para-associative ternary partial product. Moreover, the null tangent bundle is an example of a non-polynomial graded bundle.
description: 8 pages. Comments are most welcomed
The Effect of Tuberculosis Treatment on Virologic and Immunologic Response to Combination Antiretroviral Therapy Among South African Children
Creators: name: Soeters, Heidi M.
name: Moultrie, Harry
name: Rie, Annelies Van
name: Sawry, Shobna
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Many HIV-infected children are diagnosed with tuberculosis (TB), but the effect of TB treatment on virologic and immunologic response to combination antiretroviral therapy (cART) is not well documented.
D3.7 Report on the execution of the interworking test suites
Creators: name: Pérez, Ramón
name: Pergolesi, Matteo
name: Reali, Gianluca
name: Lombardo, Francesco
name: Lungaroni, Paolo
name: Salsano, Stefano
name: Melazzi, Nicola Blefari
name: Mollà, Marc
name: Iovanna, Paola
name: Ubaldi, Fabio
name: Sessler, Anna
name: Gopalasingham Aravinthan
name: Bernini, Giacomo
name: Agueci, Leonardo
name: Landi, Giada
name: Michał Grzesik
name: Panek, Grzegorz
name: Rodríguez, Juan
name: Luque, Lourdes
name: Contreras, Luis Miguel
name: Ntogkas, Christos
name: Kosmatos, Evangelos
name: Trichias, Kostas
name: Makantasis, George
Publisher: name: Zenodo
Year: 2020

description: Deliverable D3.7 presents the results regarding the execution of the test cases defined in D3.6 [1], in order to validate the features exposed for each component placed in the Interworking (I/W) Framework, possible interconnections between them and aspects related to the system itself; for example, the interconnection between the I/W Framework and each site facility.
 This is the final deliverable within task T3.4, related to the Interworking testing process. As a result, this deliverable firstly summarizes and concludes some specific chapters introduced in D3.6 [1], namely an overview of the tests done, a summary of the testing methodology used in the process, an update of the risk plan taking into account the effects caused by the COVID-19, a final specification of the testing roadmap with the corresponding dates in which each milestone has been achieved, and a reminder of the testing tools to be used for performing the tests.
 Then, the test results are reported by following a homogeneous format, similar to what was proposed in D3.6 [1]. This is really important in order to be able to analyse the test results with the same criteria for all the cases. In general, what can be extracted from the execution of the test cases reported in this deliverable is that the Interworking Layer is prepared to be deployed and operated in the expected production environment, as most of the components that belong to the IWL have successfully passed their corresponding test suites. However, there are still some test cases to be executed in the near future, as some of them had to be delayed due to several reasons; mainly, due to the COVID-19 situation. These pending test cases will be reported in D3.5 [2] due next year, also coinciding with the final version of the Interworking Layer. To achieve that, a continuous integration process will be followed, and potential failures discovered during the system deployment and the way to solve them will be described in that deliverable.
Establishment of vestibular schwannoma primary cell cultures obtained from cavitron ultrasonic surgical aspirator tissue material
Creators: name: Leisz, Sandra
name: Klause, Clara Helene
name: Becker, Anna-Louisa
name: Scheer, Maximilian
name: Simmermacher, Sebastian
name: Strauss, Christian
name: Scheller, Christian
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 617

description: Background: Vestibular schwannoma (VS) is a benign tumor arising from the Schwann cells of the eighth cranial nerve. The complexity in treatment is associated with unpredictable progression of this tumor. Some of the VS do not alter for years, while others rapidly increase in size. The mechanisms behind size progression are not well studied. Furthermore, despite several studies, there is no pharmacological treatment available for sporadic VS. Therefore, in vitro models are essential tools to study the cellular and molecular processes of VS. In addition, patient-derived cell cultures are important for substance screening to investigate pharmacological approaches in vitro. New method: This study presents a simple and fast method for culturing VS cells from patient tissue material obtained using a cavitron ultrasonic surgical aspirator (CUSA). In addition, the cells were characterized based on the expression of schwannoma markers, growth properties and screened for fibroblast contamination. Result: We could show that CUSA obtained material is a suitable resource for isolation of VS primary cultures and enables real time analysis on living cells. Comparison with Existing Methods: To date, only a few protocols are available for culturing VS cells from patient tissue material. A disadvantage of these methods is the relatively large amount of tissue needed to obtain the primary cells, which can be difficult, especially in small VS. By obtaining the cells from the CUSA, there is the possibility to establish a primary culture even with limited material. Conclusion: This approach could be particularly useful for testing substances that represent candidates for drug therapy of vestibular schwannoma.
Thermal and dimensional evaluation of a test plate for assessing the measurement capability of a thermal imager within nuclear decommissioning storage
Creators: name: McMillan, Jamie Luke
name: Hayes, Michael
name: Hornby, Rob
name: Korniliou, Sofia
name: Jones, Christopher
name: O'Connor, Daniel
name: Simpson, Rob
name: Machin, Graham
name: Bernard, Robert
name: Gallagher, Chris
Publisher: name: arXiv
Year: 2022
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: In this laboratory-based study, a plate was designed, manufactured and then characterised thermally and dimensionally using a thermal imager. This plate comprised a range of known scratch, dent, thinning and pitting artefacts as mimics of possible surface anomalies, as well as an arrangement of higher emissivity targets. The thermal and dimensional characterisation of this plate facilitated surface temperature determination. This was verified through thermal models and successful defect identification of the scratch and pitting artefacts at temperatures from \SIrange{30}{170}{\celsius}. These laboratory measurements demonstrated the feasibility of deploying in-situ thermal imaging to the thermal and dimensional characterisation of special nuclear material containers. Surface temperature determination demonstrated uncertainties from \SIrange{1.0}{6.8}{\celsius} (\(k = 2\)). The principle challenges inhibiting successful deployment are a lack of suitable emissivity data and a robust defect identification algorithm suited to both static and transient datasets.
Tunable nano-plasmonic photodetectors
Creators: name: Pertsch, Patrick
name: Kullock, René
name: Gabriel, Vinzenz
name: Zurak, Luka
name: Emmerling, Monika
name: Hecht, Bert
Publisher: name: arXiv
Year: 2022
Subjects: subject: Optics (physics.optics)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: Visible and infrared photons can be detected with a broadband response via the internal photoeffect. By using plasmonic nanostructures, i.e. nanoantennas, wavelength selectivity can be introduced to such detectors through geometry-dependent resonances. Also, additional functionality, like electronic responsivity switching and polarization detection have been realized. However, previous devices consisted of large arrays of nanostructures to achieve detectable photocurrents. Here we show that this concept can be scaled down to a single antenna level, resulting in detector dimensions well below the resonance wavelength of the device. Our design consists of a single electrically-connected plasmonic nanoantenna covered with a wide-bandgap semiconductor allowing broadband photodetection in the VIS/NIR via injection of hot carriers. We demonstrate electrical switching of the color sensitivity as well as polarization detection. Our results hold promise for the realization of ultra small, highly integratable photodetectors with advanced functionality.
description: 8 pages, 4 figures
Entanglement quantification enhanced by dark count correction
Creators: name: Czerwinski, Artur
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: In this letter, we propose a method of dark count correction in quantum state tomography of entangled photon pairs. The framework is based on a linear model of dark counts, which is imposed on the measurement formalism. The method is tested on empirical data derived from an experiment on polarization-entangled photons. We demonstrate that the numerical approach to dark count correction guarantees more reliable state reconstruction compared with standard estimation. Most importantly, however, the conceptually simple theoretical approach proves to be more efficient at entanglement quantification than experimental techniques.
Synthesis and characterization of dimeric artesunate glycerol monocaprylate conjugate and formulation of nanoemulsion preconcentrate
Creators: name: Hore, Rana
name: Hasan, Nazmul
name: Mäder, Karsten
name: Kressler, Jörg
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 540

description: Malaria is one of the major life-threatening health problems worldwide. Artesunate is the most potent antimalarial drug to combat severe malaria. However, development of drug resistance, short plasma half-life, and poor bioavailability limit the efficacy of this drug. Here, we applied the dimerization concept to synthesize dimeric artesunate glycerol monocaprylate conjugate (D-AS-GC) by conjugating artesunate (AS) with glycerol monocaprylate (GC) via esterification reaction. D-AS-GC conjugate, AS, and GC were well characterized by 1H NMR, attached proton test (APT) 13C NMR and 2D NMR spectroscopy. D-AS-GC conjugate was further analyzed by ESI-TOF MS. Finally, a series of nanoemulsion preconcentrate (F1–F6) of D-AS-GC was prepared by mixing different ratios of oil and surfactant/cosurfactant and evaluated after dilution with an aqueous phase. The optimized formulation (F6) exhibits a clear nanoemulsion and the hydrodynamic diameter of the dispersed phase was determined by DLS and DOSY NMR spectroscopy. The morphology of the nanoemulsion droplets of F6 was investigated by AFM, which revealed the formation of tiny nanoemulsion droplets on a hydrophilic mica substrate. Moreover, using a less polar silicon wafer led to the formation of larger droplets with a spherical core shell-like structure. Overall, the rational design of the dimeric artesunate-based nanoemulsion preconcentrate could potentially be used in more efficient drug delivery systems.
Tegecoelotes secunda Paik 1971
Creators: name: Marusik, Yuri M.
name: Koponen, Seppo
Publisher: name: Zenodo
Year: 2000
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Amaurobiidae
Tegecoelotes
Tegecoelotes secunda

description: Tegecoelotes secunda (Paik, 1971) com b.n. Tegenaria secunda Paik, 1971: 22, f. 8-13; Coelotes bicaudatus Paik, 1976: 81, f. 3, 13-15, syn.n. Material examined: 1 ♂, 3 ♀♀, env. of Vladivostok, Okeanskaya, forest litter, 2.10.1997, YM.; 1 ♂ (IBPN), Ussuriysky Reserve, Komarovo-Zapovednoe, 43°39'N 132º20.7'E, 22— 29.07.1999, YS. COMMENTS. Recently, a new genus was described for this species and two specific names were synonymis ed (C. bicaudatus and C. erraticus Nishikawa, 1983) [Ovchinnikov, 1999]. T. secunda is recorded in the southern part o f Maritime Province, Russia [Ovchinnikov, 1999]]. In addition to Russia, known also from South Korea, Japan and Liaoning, China [Ovchinnikov, 1999; Song el al., 1999].
description: Published as part of Marusik, Yuri M. & Koponen, Seppo, 2000, New data on spiders (Aranei) from the Maritime Province, Russian Far East, pp. 55-68 in Arthropoda Selecta 9 (1) on page 56, DOI: 10.5281/zenodo.822713
description: {"references": ["Paik K. Y. 1971. Korean spiders of genus Tegenaria (Araneae, Agelenidae) / / Korean J. Zool. Vol. 14. No. l. P. 19 - 26.", "Paik K. Y. 1976. Five new spiders of genus Coelotes / / Educ. J. leach. Coll. Kyungpook Univ. Vol. l 8. P. 77 - 88.", "Ovchinnikov S. V. 1999. On the supraspecific systematics of the subfamily Coelotinae (Araneae, Amaurobiidae) in the former USSR fauna / / TETHYS Entomological Research. Vol. 1. P. 63 - 80 [in Russian, with English summary],", "Song DX, Zhu, M. S, Chen, J. 1999. The spiders of China. Hebei Science & Technology Press. 640 pp."]}
Impact of preceded tumor therapeutic irradiation on the microtensile bond strength of universal adhesives applied in self-etch mode to human dentin in vitro
Creators: name: Broscheit, Sina
name: Vordermark, Dirk
name: Gerlach, Reinhard
name: Gernhardt, Christian
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: The aim of this study was to investigate the effect of preceded tumor therapeutic irradiation on the tensile bond strength of three modern universal adhesives applied in self-etch mode on dentin. Specimens prepared from 135 extracted human third molars were divided into three superior groups. These received either no radiation, 5 Gy, or a total dose of 60 Gy in vitro irradiation, fractionally applied. The samples of each group were further randomly assigned to six subgroups to test three adhesives (Futurabond® U, Voco; AdheSE® Universal Ivoclar Vivadent; Xeno® Select, Dentsply Sirona) in the self-etch application mode (n = 15). Tensile bond strength was determined using a universal testing machine (1.0 mm/min). Data were analyzed with ANOVA (p < 0.01) and Tukey’s test (p < 0.05). The influence of irradiation on the microtensile bond strength of the used dentin adhesives proved to be significant. For each material, a decrease in adhesion value was registered after irradiation. However, only for the material Xeno® Select were significantly reduced adhesion values determined after irradiation with 60 Gy compared to 0 Gy. Within the limitations of an in vitro study, some effects of tumor therapeutic irradiation of human dentin on the tensile bond strength of universal adhesives used in self-etch mode could be observed. Those decreases were only partly significant, depending on the material and the radiation dose. Whether the tensile bond strength on irradiated dentin depends on the particular application mode (etch-and-rinse vs. self-etch) of the universal adhesives remains to be investigated.
Seeing the forest for the trees in targeted protein degradation
Creators: name: Kostic, Milka
Publisher: name: Zenodo
Year: 2020
Subjects: chemical biology
drug discovery
drug development
targeted protein degradation
strategic scientific development

description: Targeted protein degradation is fascinating, promising, exciting, intriguing, different, unique... but is it also hyped? As any technology that breaks new conceptual grounds and opens previously unforeseen circumstances, targeted protein degradation is subject to the technology hype cycle. In this presentation, I provide the basic introduction to the field, and comment on how we can navigate the hype cycle to advance the field faster.
PBW filtration and monomial bases for Demazure modules in types A and C
Creators: name: Balla, George
name: Fourier, Ghislain
name: Kambaso, Kunda
Publisher: name: arXiv
Year: 2022
Subjects: subject: Representation Theory (math.RT)
subject: Algebraic Geometry (math.AG)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 05E10, 14M15, 17B10

description: We characterise the symplectic Weyl group elements such that the FFLV basis is compatible with the PBW filtration on symplectic Demazure modules, extending type A results by the second author. Surprisingly, the number of such elements depends not on the type A or C of the Lie algebra but on the rank only.
description: 20 pages
Etiology, classification, diagnostics, and conservative management of osteochondral lesions of the talus : 2023 recommendations of the working group "Clinical Tissue Regeneration" of the German society of orthopedics and traumatology
Creators: name: Walther, Markus
name: Aurich, Matthias
name: [Und Viele Weitere]
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: The working group, “Clinical Tissue Regeneration” of the German Society of Orthopedics and Traumatology (DGOU) issues this paper to update their guidelines. Methods: Peer-reviewed literature was analyzed regarding different topics relevant to osteochondral lesions of the talus (OLTs) treatment. This process concluded with a statement for each topic reflecting the best scientific evidence available for a particular diagnostic or therapeutic concept, including the grade of recommendation. Besides the scientific evidence, all group members rated the statements to identify possible gaps between literature and current clinical practice. Conclusion: In patients with minimal symptoms, OLT progression to ankle osteoarthritis is unlikely. Risk factors for progression are the depth of the lesion on MRI, subchondral cyst formation, and the extent of bone marrow edema. Conservative management is the adaptation of activities to the performance of the ankle joint. A follow-up imaging after 12 months helps not to miss any progression. It is impossible to estimate the probability of success of conservative management from initial symptoms and imaging. Cast immobilization is an option in OLTs in children, with a success rate of approximately 50%, although complete healing, estimated from imaging, is rare. In adults, improvement by conservative management ranges between 45% and 59%. Rest and restrictions for sports activities seem to be more successful than immobilization. Intra-articular injections of hyaluronic acid and platelet-rich plasma can improve pain and functional scores for more than 6 months. If 3 months of conservative management does not improve symptoms, surgery can be recommended.
title: Clinical and theoretical studies with the opioid analgesic fentanyl
Creators: name: Higgins, Michael Joseph
Publisher: name: University of Glasgow
Year: 1990

description: This thesis concerns two investigations into the opioid analgesic fentanyl. The first is a clinical investigation into the safety and efficacy of fentanyl administered by inhalation. The second is a theoretical assessment of the feasibility and merits of applying an alternative form of pharmacokinetic model to the drug. The second project is linked chronologically and conceptually to the first in that it grew out of a general interest in the pharmacology of fentanyl developed during the first study and in that it provides a useful theoretical framework for considering the comparative pharmacokinetics of drug delivered intravenously and drug delivered for absorbtion from other sites. The thesis is in two related but essentially self-contained parts preceded by a brief review of fentanyl pharmacology.
Adherence to Early Antiretroviral Therapy: Results From HPTN 052, a Phase III, Multinational Randomized Trial of ART to Prevent HIV-1 Sexual Transmission in Serodiscordant Couples
Creators: name: Celentano, David
name: Grinsztejn, Beatriz
name: Safren, Steven A.
name: Kumarasamy, Nagalingeswaran
name: McCauley, Marybeth
name: Chen, Ying Qing
name: Hoffman, Irving
name: Cohen, Myron S.
name: Mayer, Kenneth H.
name: Hosseinipour, Mina C.
name: Ou, San-San
name: Gamble, Theresa
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Combination antiretroviral therapy (ART) for HIV-1 infected individuals prevents sexual transmission if viral load is suppressed.
On monoaural speech enhancement for automatic recognition of real noisy speech using mixture invariant training
Creators: name: Zhang, Jisi
name: Zorila, Catalin
name: Doddipatla, Rama
name: Barker, Jon
Publisher: name: arXiv
Year: 2022
Subjects: subject: Sound (cs.SD)
subject: Computation and Language (cs.CL)
subject: Audio and Speech Processing (eess.AS)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In this paper, we explore an improved framework to train a monoaural neural enhancement model for robust speech recognition. The designed training framework extends the existing mixture invariant training criterion to exploit both unpaired clean speech and real noisy data. It is found that the unpaired clean speech is crucial to improve quality of separated speech from real noisy speech. The proposed method also performs remixing of processed and unprocessed signals to alleviate the processing artifacts. Experiments on the single-channel CHiME-3 real test sets show that the proposed method improves significantly in terms of speech recognition performance over the enhancement system trained either on the mismatched simulated data in a supervised fashion or on the matched real data in an unsupervised fashion. Between 16% and 39% relative WER reduction has been achieved by the proposed system compared to the unprocessed signal using end-to-end and hybrid acoustic models without retraining on distorted data.
description: Accepted to INTERSPEECH 2022
C-reactive protein level and the genetic variant rs1130864 in the CRP gene as prognostic factors for 10-year cardiovascular outcome
Creators: name: Schulz, Susanne
name: Rehm, Selina
name: Schlitt, Axel
name: Lierath, Madlen
name: Lüdike, Henriette
name: Hofmann, Britt
name: Bitter, Kerstin
name: Reichert, Stefan
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Background: Cardiovascular disease (CVD) is the primary cause of premature death and disability worldwide. There is extensive evidence that inflammation represents an important pathogenetic mechanism in the development and prognosis of CVD. C-reactive protein (CRP) is a potential marker of vascular inflammation and plays a direct role in CVD by promoting vascular inflammation. The objective of this study (ClinTrials.gov identifier: NCT01045070) was to assess the prognostic impact of CRP protein levels and genetic variants of CRP gene events on cardiovascular (CV) outcome (10-year follow-up) in patients suffering from CVD. Methods: CVD patients were prospectively included in this study (n = 1002) and followed up (10 years) regarding combined CV endpoint (CV death, death from stroke, myocardial infarction (MI), and stroke/transient ischemic attack (TIA)). CRP protein level (particle-enhanced immunological turbidity test) and genetic variants (rs1130864, rs1417938, rs1800947, rs3093077; polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) after DNA extraction from EDTA-blood) were evaluated. Results: In survival analyses, increased CRP protein levels of ≥5 mg/L (log-rank test: p < 0.001, Cox regression: p = 0.002, hazard ratio = 1.49) and CT + TT genotype of rs1130864 (log-rank test: p = 0.041; Cox regression: p = 0.103, hazard ratio = 1.21) were associated with a weaker CV prognosis considering combined CV endpoint. Conclusions: Elevated CRP level and genetic variant (rs1130864) were proven to provide prognostic value for adverse outcome in CVD patients within the 10-year follow-up period.
RSPA_supplementary_information.pdf from Effect of defects and reinforcements on the mechanical behaviour of a bi-layered panel
Creators: name: Wu, C. L.
name: Zhang, L. L.
name: Yin, H. M.
Publisher: name: The Royal Society
Year: 2023
Subjects: subject: Mechanics
subject: 10301 Numerical Analysis
subject: FOS: Mathematics
subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: Supplementary information and introduction of bi-material iBEM
Time-dependent Spinor field in a static cylindrically-symmetric space-time
Creators: name: Saha, Bijan
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Within the scope of a static cylindrically symmetric space-time we study the behavior of a nonlinear spinor field that depends on time and radial coordinates. It is found that the presence of nontrivial non-diagonal components of the energy-momentum tensor (EMT) imposes some restriction on both the metric functions and the spinor field. While for the time independent spinor field there occur three way restrictions resembling the Bianchi type-I Universe, in this case things become more complicated.
description: 9 pages, 8 figures
Drought-stress-related reprogramming of gene expression in barley involves differential histone modifications at ABA-related genes
Creators: name: Ost, Charloote
name: Cao, Hieu Xuan
name: Nguyễn, Thùy Linh
name: Himmelbach, Axel
name: Mascher, Martin
name: Stein, Nils
name: Humbeck, Klaus
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 570

description: Plants respond to drought by the major reprogramming of gene expression, enabling the plant to survive this threatening environmental condition. The phytohormone abscisic acid (ABA) serves as a crucial upstream signal, inducing this multifaceted process. This report investigated the drought response in barley plants (Hordeum vulgare, cv. Morex) at both the epigenome and transcriptome levels. After a ten-day drought period, during which the soil water content was reduced by about 35%, the relative chlorophyll content, as well as the photosystem II efficiency of the barley leaves, decreased by about 10%. Furthermore, drought-related genes such as HvS40 and HvA1 were already induced compared to the well-watered controls. Global ChIP-Seq analysis was performed to identify genes in which histones H3 were modified with euchromatic K4 trimethylation or K9 acetylation during drought. By applying stringent exclusion criteria, 129 genes loaded with H3K4me3 and 2008 genes loaded with H3K9ac in response to drought were identified, indicating that H3K9 acetylation reacts to drought more sensitively than H3K4 trimethylation. A comparison with differentially expressed genes enabled the identification of specific genes loaded with the euchromatic marks and induced in response to drought treatment. The results revealed that a major proportion of these genes are involved in ABA signaling and related pathways. Intriguingly, two members of the protein phosphatase 2C family (PP2Cs), which play a crucial role in the central regulatory machinery of ABA signaling, were also identified through this approach.
title: The sociolinguistics of learning: attitudinal patterns and implications (a case study of Moroccan diglossia)
Creators: name: Boussalhi, Abdelfattah
Publisher: name: University of Glasgow
Year: 1991
Subjects: subject: Sociolinguistics, linguistics, modern language, language.

description: The present dissertation is a study of the attitudinal patterns and educational implications particular to the diglossic relationship between MA and CA. This relationship is characterised by the sole implementation of CA and the exclusion of MA from the formal learning process. This is particularly significant if we consider that only MA is a naturally acquired language. The first chapter is a review of the relevant aspects of sociolinguistic literature on the relationships between standard and nonstandard languages, and the treatment of linguistic diversity in general. The discussion centres around the importance of the notion of communicative competence, the different hypotheses on the social stratification of language, and the interpretation of linguistic differences. Other studies which are covered are those of attitudes towards languages and the particular impact of these on teachers and educational achievement, those of vernaculars, and, very briefly, those of language planning. The second chapter discusses the various facets of general diglossic research, and particularly the distinctiveness of diglossia from other instances of linguistic relatedness and functional distribution. The second part of this chapter focuses on the particular situation of Arabic diglossia. Particular emphasis is placed on the attitudinal component of Arabic variation. The arguments of this chapter include those concerning the relativity of ESA to Arabic vernaculars, and those concerning the linguistic, historical, communicative, and national status of Arabic vernaculars. The third chapter briefly describes the Moroccan educational system, and outlines its language policy. The nature of traditional Arabic linguistic studies is also discussed and compared to that of modern theories on language. The arguments include those concerning the relativity of CA studies to early Arabic grammatical tradition. The fourth and fifth chapters are a study of attitudes towards MA and CA, on the basis of data obtained from the results of two questionnaires: one addressed to students and the other to teachers. The two chapters include a description of the results and their interpretation. These two chapters draw conclusions as to the nature of attitudinal patterns to MA-CA diglossia. The fourth and fifth chapters are a study of attitudes towards MA and CA, on the basis of data obtained from the results of two questionnaires: one addressed to students and the other to teachers. The two chapters include a description of the results and their interpretation. These two chapters draw conclusions as to the nature of attitudinal patterns to MA-CA diglossia.
Paracoelotes spinivulva Simon 1880
Creators: name: Marusik, Yuri M.
name: Koponen, Seppo
Publisher: name: Zenodo
Year: 2000
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Agelenidae
Paracoelotes
Paracoelotes spinivulva

description: Paracoelotes spinivulva (Simon, 1880) Coelotes subluctuosus Zhu & Wang, 1994: 40, fig. 9-12, syn.n. Other species in synonymy with P. spinivulva: Coelotes csikii Kulczynski. 1901 (after Lehtinen, 1967 and Song, 1987); Cedicus mollendorffi Karsch, 1881 (after Lehtinen, 1967); Coelotes yunnanensis Schenkel, 1963 (after Lehtinen, 1967); Coelotes luctuosus schensiensis Schenkel, 1963 (after Lehtin­ en, 1967 and Song, 1987); Coelotes vulgaris Paik, 1978 (after Song et al„ 1999). Material examined: 4♀♀, [09] env. of Anisimovka Vill., 43º10'N 132º46'E, 24- 28.07.1998, YM.; 4 ♂ ♀. [21] Khasan Distr., env. of Andreevka Vill., 42º35-36'N 131º13'E, 11- 15.08.1998, YM. COMMENTS. The largest representative o f the genus in Russia, being reported earlier from the Russian Far East by Oliger [1984, sub Coelotes luctuosus (L.Koch, 1878)] and Ovchinnikov [1999]. In addition to Russia, known also from Korea and China [Ovchinnikov, 1999; Song et al., 1999],
description: Published as part of Marusik, Yuri M. & Koponen, Seppo, 2000, New data on spiders (Aranei) from the Maritime Province, Russian Far East, pp. 55-68 in Arthropoda Selecta 9 (1) on page 56, DOI: 10.5281/zenodo.822713
description: {"references": ["Zhu C. D, Wang J. F. 1994. Seven new species of the genus Coelotes from China (Araneae; Agelenidae) / / Acta zootax - on. sin. Vol. 19. P. 37 - 45", "Lehtinen P. T. 1967. Classification of the Cribellate spiders and some allied families, with notes on the evolution of the suborder Araneomorpha / / Ann. Zool. Fennici. Vol. 4. No. 3. P. 199 - 467.", "Song DX 1987. Spiders from agricultural regions of China (Arachnida: Araneae). Beijing; Agriculture Publishing House. 376 pp. [in Chinese]", "Schenkel E. 1963. Ostasiatische Spinnen aus dem Museum d'Histoire naturelle de Paris / / Mem. Mus. natn. Hist. nat. Paris. Ser. A, Zool. Vol., 25. No. l- 2. P. l- 481.", "Paik K. Y. 1978. Illustrated flora and fauna of Korea. 21. Araneae. Seoul, Korea, Ministry of Education. 546 pp. (in Korean]", "Song DX, Zhu, M. S, Chen, J. 1999. The spiders of China. Hebei Science & Technology Press. 640 pp.", "Ovchinnikov S. V. 1999. On the supraspecific systematics of the subfamily Coelotinae (Araneae, Amaurobiidae) in the former USSR fauna / / TETHYS Entomological Research. Vol. 1. P. 63 - 80 [in Russian, with English summary],"]}
D3.4 Second implementation of the interworking reference model
Creators: name: Perez, Ramón
name: Zabala, Aitor
name: M. Pergolesi
name: M. Femminella
name: F. Lombardo Francesco
name: P. Lungaroni Salsano
name: N. Blefari Melazzi
name: Bernini, Giacomo
name: Agueci, Leonardo
name: Landi, Giada
name: Gopolasingham Aravinthan
name: Roselló, Marc Mollà
name: Garcia-Reinoso, Jaime
name: Yañez-Mingot, Pablo Serrano
name: Panek, Grzegorz
name: Contreras, Luis Miguel
name: Luque, Lourdes
name: Rodriguez, Juan
name: Alvarez, Federico
name: Jimenez, David
name: Serrano, Javier
name: Rio, Alberto Del
name: P. Vlacheas
name: V. Foteinos
name: I. Belikaidis
name: V. Kosmatos
name: K. Trichias,
name: A. Skalidi
name: C. Ntogkas
name: A. Gkiolias
name: I. Chondroulis
name: A. Demou
name: A. Athanesselis
name: M. Mitrou
Publisher: name: Zenodo
Year: 2020

description: Deliverable D3.4 is the second deliverable dealing with the implementation of the Interworking Layer (IWL).
 This deliverable includes all IWL components as they are tested and integrated internally and with other 5G EVE components (5G EVE Portal, 5G EVE sites), as we describe in the deliverable D3.7.
 One of the biggest efforts done in the scope of WP3 during the last third of the second year of the project is the integration of the IWL components. We integrated and tested the components first internally, and later with the other 5G EVE components of the 5G EVE Portal and the 5G EVE sites. Most of this integration has been done during the COVID-19 situation, which impacted the normal execution of the project due to the restrictions on working physically in the sites. However, we delivered in time the IWL components with the required scope and now IWL is integrated with the 5G EVE Portal and we tested the integration with OSM and ONAP NFV-Os.
 As we explain in the Roadmap section, we managed the scope of the IWL roadmap for delaying those part that are not essential today for the project, without impacting the services and features offered by 5G EVE. In addition, we also managed the incorporation of new requirements: (i) a new Gaming use case coming from Telefonica and incorporated in the last amendment of the project, (ii) new requirements for integrating a new kind of orchestrators that are focused in RAN management and (iii) the development of a new component, called IWL repository, which exposes information related to the architecture of the 5G EVE sites. The seamless incorporation of these new requirements demonstrates that the open and modular IWL architecture allows to change, evolve or enhance any part of the IWL for adapting it to future requirements.
 We also update in this report the information related to inter-site connectivity, which is core for supporting the multi-site experiments execution.
Antiretroviral Treatment Is Associated With Iron Deficiency in HIV-Infected Malawian Women That Is Mitigated With Supplementation, but Is Not Associated With Infant Iron Deficiency During 24 Weeks of Exclusive Breastfeeding
Creators: name: Widen, Elizabeth M.
name: Adair, Linda S.
name: Jamieson, Denise J.
name: Chasela, Charles S.
name: Kayira, Dumbani
name: Flax, Valerie L.
name: Tegha, Gerald
name: Allen, Lindsay H.
name: Kourtis, Athena P.
name: Ellington, Sascha R.
name: Shahab-Ferdows, Setareh
name: van der Horst, Charles M.
name: Kacheche, Zebrone
name: Bentley, Margaret E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: In resource-limited settings without safe alternatives to breastfeeding, the WHO recommends exclusive breastfeeding and antiretroviral (ARV) prophylaxis. Given the high prevalence of anemia among HIV-infected women, mothers and their infants (via fetal iron accretion) may be at risk of iron deficiency. We assessed the effects of maternal micronutrient-fortified lipid-based nutrient supplements (LNS) and maternal ARV treatment or infant ARV prophylaxis on maternal and infant iron status during exclusive breastfeeding from birth to 24 weeks.