cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Three-Dimensional Aquila Rift: Magnetized HI Arch Anchored by Molecular Complex
Creators: name: Sofue, Yoshiaki
name: Nakanishi, Hiroyuki
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Three dimensional structure of the Aquila Rift of magnetized neutral gas is investigated by analyzing HI and CO line data. The projected distance on the Galactic plane of the HI arch of the Rift is ~250 pc from the Sun. The HI arch emerges at l~ 30 deg, reaches to altitudes as high as ~ 500 pc above the plane at l~ 350deg, and returns to the disk at l~270 deg. The extent of arch at positive latitudes is ~1 kpc and radius is ~100 pc. The eastern root is associated with the giant molecular cloud complex, which is the main body of the optically defined Aquila Rift. The HI and molecular masses of the Rift are estimated to be M_HI~1.4x10^5Msun and M_H2 ~3x10^5 Msun. Gravitational energies to lift the gases to their heights are E_grav: HI ~1.4x10^51 and E_grav: H_2 ~0.3x10^51 erg, respectively. Magnetic field is aligned along the HI arch of the Rift, and the strength is measured to be B~10 microG using Faraday rotation measures of extragalactic radio sources. The magnetic energy is estimated to be E_mag~1.2x10^51 erg. A possible mechanism of formation of the Aquila Rift is proposed in terms of interstellar magnetic inflation by a sinusoidal Parker instability of wavelength of ~2.5 kpc and amplitude ~500 pc.
description: 12 pages, 14 figures, submitted to MNRAS
Transcrystallinity as a factor in controlling adhesion
Creators: name: Ritchie, Philip John Allan
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
The Sources of the Recent Inflationary Experience in Ethiopia
Creators: name: Tafere, Kibrom
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2008

description: One of the prime objectives of governments is achieving stable macroeconomic condition. This objective requires that prices be kept to a reasonably stable level. High and persistent inflation introduces uncertainties into the economy and may lead to slowdown of economic growth by discouraging domestic as well as foreign investments. It may also cause balance of payments problems by eroding a country's competitive advantage. Moreover, because it hits the poor the most it needs to be tackled. This study aims at understanding the forces behind the current inflationary process in Ethiopia. In order to achieve the stated objective a synthesis model of monetarist and cost-push inflation theories is estimated using vector autoregressive (VAR) and single equation error correction models. The estimated models enable to understand the short run and the long run price dynamics in Ethiopia between 1994/95 and 2007/08. The findings of the study suggest that the determinants of inflation differ between sectors (food and non-food) and the time horizons under consideration. The most important forces behind food inflation in the long run are real income, money supply, inflation expectation and international food price. The long run determinants of non-food inflation, on the other hand, are money supply, interest rate and inflation expectations. In the short run model, wages, international prices, exchange rates and food supply are found to be prime sources of inflation. There is also evidence of cost mark-up in the short run suggesting the presence of strong monopoly power in price formation. To contain inflation, therefore, the government needs to exercise prudent fiscal and monetary policies. Inflation expectations need to be tackled by way of credible government policies to change public opinion. In this regard it is important to consider targeting of macroeconomic variables and adhere to announced targets.
La-doping effect on spin-orbit coupled Sr2IrO4 probed by x-ray absorption spectroscopy
Creators: name: Cheng, Jie
name: Sun, Xuanyong
name: Liu, Shengli
name: Li, Bin
name: Wang, Haiyun
name: Dong, Peng
name: Wang, Yu
name: Xu, Wei
Publisher: name: arXiv
Year: 2016
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Sr2IrO4 was predicted to be an unconventional superconductor upon carrier doping since it highly resembles the high-temperature cuprates. Here, to understand carrier doping effect on spin-orbit coupled Mott insulator Sr2IrO4, the electronic structure and local structure distortion for Sr2-xLaxIrO4 system have been investigated by x-ray absorption spectroscopy (XAS). By comparing the intensity of white-line features at the Ir L2,3 absorption edges, we observe remarkably large branching ratios in La-doped compounds, greater than that of the parent material Sr2IrO4, suggesting a strong spin-orbit interaction (SOI) for Sr2IrO4-based system. Moreover, extended x-ray absorption fine structure (EXAFS) spectra demonstrate more regular IrO6 octahedra, i.e. the weakened crystal electric field (CEF) versus La-doping. By theoretical calculations, the synergistic effect of regular IrO6 octahedra and electron doping is established, which accounts for the transition from a Mott insulator to a conductive state in Sr2-xLaxIrO4-based system.
description: 14 pages, 6 figures. arXiv admin note: text overlap with arXiv:1610.09817
An Empirical Analysis of the Determinants of the Current Account In Ethiopia (1961/62 - 1999/00)
Creators: name: Tesfamariam, Gebreegziabher
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2007

description: This study analyzes the role of fundamental macroeconomic variables in explaining the movements of the current account balance in Ethiopia and describes the trends and profiles of the current account balance and its major components in three different regimes using data covering the period 1961/62-1999/00. Current account in Ethiopia had been in a persistent deficit due to the poor performance of exports to finance the growing import bills. In estimating the model, the ADF tests for unit root show that all the variables are integrated of order one. The Johansen's likelihood ratio test for co-integration indicates that there is one co-integration vector. The test for weak exogeneity also suggests that all the explanatory variables except capital flow are weakly exogenous, while the exogeneity test for current account balance is strongly rejected. The empirical results reveal that budget balance, broad money, relative income and terms of trade affect the current account balance significantly both in the long run and in the short run, while the effects of dependency ratio and openness are significant only in the short run. The policy implication of the findings is that reducing budget deficit, controlling monetary expansion, controlling birth rate (through family planning), achieving overall economic development, improving the diversity and quality of exports and liberalizing external trade will eliminate the persistent deficits of the Ethiopian current account balance. Key words: determination of current account, inter-temporal substitution effect, consumption smoothing effect, co-integration analysis, and error correction method.
The automorphism group of a rigid affine variety
Creators: name: Arzhantsev, Ivan
name: Gaifullin, Sergey
Publisher: name: arXiv
Year: 2016
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 14J50, 14R20 (Primary), 13A50, 14L30 (Secondary)

description: An irreducible algebraic variety $X$ is rigid if it admits no nontrivial action of the additive group of the ground field. We prove that the automorphism group $\text{Aut}(X)$ of a rigid affine variety contains a unique maximal torus $\mathbb{T}$. If the grading on the algebra of regular functions $\mathbb{K}[X]$ defined by the action of $\mathbb{T}$ is pointed, the group $\text{Aut}(X)$ is a finite extension of $\mathbb{T}$. As an application, we describe the automorphism group of a rigid trinomial affine hypersurface and find all isomorphisms between such hypersurfaces.
description: 12 pages
Trade and Industrial Policies in East Asia: in Search of Lessons for Africa
Creators: name: Samaro, Zinabu
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2006

description: Most African economies have not achieved any significant level of industrialization and export diversification to date; and so, the continent remains the least industrialized in the world. In response, with strong conviction that economic theory has irrefutably proved the superiority of free trade and laissez-faire industrial policies, the governments and international economic institutions of the developed countries have been pressurizing African governments to free their external trade and minimize their involvement in the form of industrial policies. Under such a context, this study analyzes the trade and industrial policy experiences of three East Asian countries. It also analyzes the terms of trade implications of export diversification into manufacturing under the context of "new export pessimism" using data for six East Asian countries. The study finds that the governments of the countries studied deliberately and consistently employed policies that are against the free trade and laissez-faire paradigms and resorted to a strategic approach to industrial development and international trade. The study also finds that export diversification into manufacturing have had a positive impact on the terms of trade of the countries studied. And therefore, it suggests selective, dynamic, predictable and performance based protection and promotion of infant industries contexutualized to the current global conditions and where the government has the willingness and the ability to withdraw the protection and promotion. Key Words: Industrialization, Infant Industry, Terms of Trade, Panel Cointegration
Mechanism of electron transfers mediated by cytochromes c and b5 in mitochondria and endoplasmic reticulum: classical and murburn perspectives
Creators: name: Gideon, Daniel Andrew
name: Nirusimhan, Vijay
name: E, Jesu Castin
name: Sudarsha, Karthik
name: Manoj, Kelath Murali
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: We explore the mechanism of electron transfers mediated by cytochrome c, a soluble protein involved in mitochondrial oxidative phosphorylation and cytochrome b5, a microsomal membrane protein acting as a redox aide in xenobiotic metabolism. We found minimal conservation in the sequence and surface amino acid residues of cytochrome c/b5 proteins among divergent species. Therefore, we question the evolutionary logic for electron transfer (ET) occurring through affinity binding via recognition of specific surface residues/topography. Also, analysis of putative protein-protein interactions in the crystal structures of these proteins and their redox partners did not point to any specific interaction logic. A comparison of the kinetic and thermodynamic constants of wildtype vs. mutants did not provide strong evidence to support the binding-based ET paradigm, but indicated support for diffusible reactive species (DRS)-mediated process. Topographically divergent cytochromes from one species have been substituted for reaction with proteins from other species, implying the involvement of non-specific interactions. We provide a viable alternative (murburn concept) to classical protein-protein binding-based long range ET mechanism. To account for the promiscuity of interactions and solvent-accessible hemes, we propose that the two proteins act as non- specific redox capacitors, mediating one-electron redox equilibriums involving DRS and unbound ions. Communicated by Ramaswamy H. Sarma
On numerical simulation of Taylor-Couette flow and state selection in Taylor vortex flow
Creators: name: Rigopoulos, John
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Exploring inside-out Doppler tomography: magnetic cataclysmic variables
Creators: name: Kotze, Enrico J.
name: Potter, Stephen B.
name: McBride, Vanessa A.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present the results of applying our inside-out velocity projection and flux modulation mapping techniques to the Doppler tomography of magnetic cataclysmic variables. The inside-out tomogram is constructed by directly projecting phase-resolved spectra onto the inside-out framework. In addition, our flux modulation mapping technique extracts any information related to the modulation of the line flux by utilising consecutive half-phase tomograms. We apply this to both the standard and the inside-out techniques. Our test cases, the polars HU Aqr and V834 Cen, and the intermediate polar PQ Gem, were chosen because of their known accretion characteristics, namely ballistic, magnetic and curtain dominated accretion, respectively. In all three cases the inside-out tomogram better exposes low-velocity emission details which are overly compacted in the standard tomogram. This is especially apparent for the mid-inclination V834 Cen where the almost blob-like blended lower velocity emission in the standard tomogram is more exposed in the inside-out tomogram, making it easier to distinguish between the ballistic and magnetically confined accretion flows that are evident in the trailed spectra. Similarly, the inside-out tomogram enhances high velocity emission details which are washed out in the standard tomogram. This is particularly effective in revealing the high velocity magnetic accretion flows in the polars HU Aqr and V834 Cen. The addition of our flux modulation technique gives a significant improvement in reproducing the trailed input spectra adding more confidence to the interpretation of the Doppler maps. Furthermore, amplitude and phase maps are constructed that further reveal amplitude and phasing characteristics of the emission components in the three test cases.
description: 12 pages, 7 figures, published in A&A
Effect of structural variation on enzymatic activity in tetranuclear (Cu4) clusters with defective cubane core
Creators: name: Khan, M. Shahnawaz
name: Khalid, Mohd
name: Ahmad, M. Shahwaz
name: Kamal, Samrah
name: Shahid, M.
name: Ahmad, Musheer
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: The stimulus to the modeling of enzyme functioning sites comes from their potential to give insight into the natural enzyme’s mechanistic pathways, ascertain the role of that different metal ion in the active site and construct better catalysts motivated by nature. The presence of metal ion leads to the activation of molecular oxygen in the metalloenzymes. The metalloenzymes such as the catechol oxidase (CO) enzyme that oxidizes the catechol to corresponding quinones which eventually protect damage tissues from plant and pathogen. Thus, the design and characterization of catalysts used as selectively and efficiently oxidation reactions have grown to be unique challenges for modern inorganic chemists. In this work, two novel tetranuclear complexes (1 and 2) have been synthesized in excellent yield. The complexes were characterized using various spectroscopic techniques such as FTIR, UV–Visible and PXRD pattern. The structure of 1 and 2 was elucidated by SC-XRD (single crystal X-ray diffraction) analysis. The magnetic study reveals the presence of the antiferromagnetic nature of 1 and 2. Both 1 and 2 shows a very good catecholase-like activity by oxidizing the catechol to analogous quinone in methanolic solution. Thus, a structure-activity relationship can further help us design other substituted tetranuclear complexes with enhanced catecholase like activity. Communicated by Ramaswamy H. Sarma
Poverty in Addis Ababa: A Comparison of Female and Male Headed Households
Creators: name: Tsehaye, Fitsum
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2002

description: An attempt has been made to compare the poverty indices between female-and male-headed households and try to identify the determinants of welfare and poverty in both households. We have employed OLS, probit and tobit models using the1995/96 HICES data. The descriptive analysis of poverty indices indicated that there is no clear trend that female-headed households are poorer than male-headed households. However, the regression result indicated female-headship has a positive influence on the welfare of the household. This study identifies other characteristics, which are generally believed to be determining poverty and welfare. The educational attainment of the household head (in particular high school and above) is found to be the most important factor that associated with poverty in all models. Similarly, the number of children in the household has a significant negative influence on the welfare of the poor and non-poor households and has positive influence on poverty gap and severity of poverty. Policies designed to see the welfare difference between female-and maleheaded households have to use definition of headship that reflect primary economic support; surveys also need to design to give this information. Thus, the issue of female-headship as proxy for targeting program of poverty alleviation is not recommended in this paper.
Design, management and EIA : a comparative study : a comparative study of the interaction and integration of EIA with engineering design in project development
Creators: name: Ridgway, Bronwyn
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Reading 2.0: New Interfaces and Reading Experiences on Mobile
Creators: name: Li, Zheng
Publisher: name: figshare
Year: 2023
Subjects: Human-computer interaction

description: "Reading 2.0: New Interfaces and Reading Experiences on Mobile" explores the design and functionality of mobile reading applications, investigating their impact on user engagement and reading comprehension. Through a user experiment involving 15 participants, the study investigates the strengths and weaknesses of three popular applications: Apple Books, Google Play Books, and Kindle. Quantitative data was collected through a System Usability Scale (SUS) Survey and Comprehension Questions, while qualitative data was gathered from open-ended questions and brief interviews. The study found that while Kindle scored highest on the SUS Survey with the lowest comprehension score, Apple Books led in comprehension, but many participants think it has less features than other two. Hence, this suggesting fewer additional features may promote deeper reading engagement. Participants' feedback highlighted several areas for improvement in current applications, including eye strain, distractions, difficulty in locating specific content, and desire for a more immersive reading experience. Additionally, participants expressed a desire for features such as customizable text size and font, adjustable screen brightness, night mode, dictionary, bookmarking, highlighting, note-taking, content sharing, and reading across devices. These insights inform recommendations for the design of future mobile reading applications, with the goal of enhancing user engagement and deepening reading experiences.
Hidden-charm pentaquarks as a meson-baryon molecule with coupled channels for $\bar{D}^{(\ast)}Λ_{\rm c}$ and $\bar{D}^{(\ast)}Σ^{(\ast)}_{\rm c}$
Creators: name: Yamaguchi, Yasuhiro
name: Santopinto, Elena
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The recent observation of two hidden-charm pentaquark states by LHCb collaborations prompted us to investigate the exotic states close to the $\bar{D}Λ_{\rm c}$, $\bar{D}^{\ast}Λ_{\rm c}$, $\bar{D}Σ_{\rm c}$, $\bar{D}Σ^{\ast}_{\rm c}$, $\bar{D}^{\ast}Σ_{\rm c}$ and $\bar{D}^{\ast}Σ^{\ast}_{\rm c}$ thresholds. We therefore studied the hadronic molecules that form the coupled-channel system of $\bar{D}^{(\ast)}Λ_{\rm c}$ and $\bar{D}^{(\ast)}Σ^{(\ast)}_{\rm c}$. As the heavy quark spin symmetry manifests the mass degenerations of $\bar{D}$ and $\bar{D}^\ast$ mesons, and of $Σ_{\rm c}$ and $Σ^\ast_{\rm c}$ baryons, the coupled channels of $\bar{D}^{(\ast)}Σ^{(\ast)}_{\rm c}$ are important in these molecules. In addition, we consider the coupling to the $\bar{D}^{(\ast)}Λ_{\rm c}$ channel whose thresholds are near the $\bar{D}^{(\ast)}Σ^{(\ast)}_{\rm c}$ thresholds, and the coupling to the state with nonzero orbital angular momentum mixed by the tensor force. This full coupled channel analysis of $\bar{D}^{(\ast)}Λ_{\rm c}-\bar{D}^{(\ast)}Σ^{(\ast)}_{\rm c}$ with larger orbital angular momentum has never been performed before. By solving the coupled-channel Schrödinger equations with the one meson exchange potentials that respected to the heavy quark spin and chiral symmetries, we studied the hidden-charm hadronic molecules with $I(J^P)=1/2(3/2^\pm)$ and $1/2(5/2^\pm)$. We conclude that the $J^P$ assignment of the observed pentaquarks is $3/2^+$ for $P^+_{\rm c}(4380)$ and $5/2^-$ for $P^+_{\rm c}(4450)$, which is agreement with the results of the LHCb analysis. In addition, we give predictions for other $J^P=3/2^\pm$ states at 4136.0, 4307.9 and 4348.7 MeV in $J^P=3/2^-$, and 4206.7 MeV in $J^P=3/2^+$, which can be further investigated by means of experiment.
description: 8 pages, 1 figure and 5 tables
Friction and damping in mechanical joints [microform]
Creators: name: Richardson, Robert Samuel Hugh
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
The Impact of Service Trade on the Economic Growth of Ethiopia: The Case of Tourism
Creators: name: Getahun, Meseret
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2011

description: International tourism is a major foreign exchange earner and a principal export for many low income countries as well as for developed countries. Now a day's many developing countries focus on economic policies for promoting international tourism as a potential source of economic growth of the country. This paper has the objective to assess whether tourism has really promoted growth based on the tourism-led growth hypothesis (TLGH) using annual data covering the period 1981-2009 for Ethiopia. Diagnostic tests, namely Augmented Dickey-Fuller (ADF) for unit root and Johanson and Juselius (JJ) for co integration test are used. The findings of the study showed that there is a positive relationship between tourism and economic growth. The results of this study suggest that government should focus on economic policies to promote international tourism as a potential source of economic growth in Ethiopia.
Classical MD and metadynamics simulations on back-pocket binders of CDK2 and VEGFR2: a guidepost to design novel small-molecule dual inhibitors
Creators: name: Vásquez, Andrés Felipe
name: Barrios, Andrés Fernando González
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Cyclin-Dependent Kinase 2 (CDK2) and Vascular-Endothelial Growth Factor Receptor 2 (VEGFR2) are promising targets for the design of novel inhibitors in anticancer therapeutics. In a recent work, our group designed a set of potential dual inhibitors predicted to occupy an allosteric back pocket near the active site of both enzymes, but their dynamic and unbinding behavior was unclear. Here, we used molecular dynamics (MD) and metadynamics (meta-D) simulations to study two of these virtual candidates (herein called IQ2 and IQ3). Their binding mode was predicted to be similar to that observed in LQ5 and BAX, well-known back-pocket binders of CDK2 and VEGFR2, respectively, including H-bonding with critical residues such as Leu83/Cys113 and Asp145/Asp190 (but excepting H-bonding with Glu51/Glu111) in CDK2/VEGFR2, correspondingly. Likewise, while LQ5 and BAX unbound through the allosteric channel as expected for type-IIA inhibitors, IQ2 and IQ3 unbound via the ATP channel (except for CDK2-IQ2) as expected for type-I½A inhibitors. Interestingly, a C-C single/double bond difference between IQ2/IQ3, respectively, resulted associated with differences in the AS/T loop flexibility observed for CDK2. These insights will help developing scaffold modifications during an optimization stage, serving as a starting point to develop dual kinase inhibitors in challenging biological targets with a promising anticancer potential. Communicated by Ramaswamy H. Sarma
Effective transitive actions of the unitary group on quotients of Hopf manifolds
Creators: name: Isaev, Alexander
Publisher: name: arXiv
Year: 2016
Subjects: subject: Complex Variables (math.CV)
subject: FOS: Mathematics
subject: 32M10, 32M05

description: In our article of 2002 joint with N. Kruzhilin we showed that every connected complex manifold of dimension $n\ge 2$ that admits an effective transitive action by holomorphic transformations of the unitary group ${\rm U}_n$ is biholomorphic to the quotient of a Hopf manifold by the action of ${\mathbb Z}_m$ for some integer $m$ satisfying $(n,m)=1$. In this note, we complement the above result with an explicit description of all effective transitive actions of ${\rm U}_n$ on such quotients, which provides an answer to a 10-year old question.
description: Final version, published online in the Journal of Geometric Analysis
On entropy change measurements around first order phase transitions in caloric materials
Creators: name: Caron, Luana
name: Doan, Nguyen Ba
name: Ranno, Laurent
Publisher: name: arXiv
Year: 2016
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: In this work we discuss the measurement protocols for indirect determination of the isothermal entropy change associated with first order phase transitions in caloric materials. The magneto- structural phase transitions giving rise to giant magnetocaloric effects in Cu-doped MnAs and FeRh are used as case studies to exemplify how badly designed protocols may affect isothermal measure- ments and lead to incorrect entropy change estimations. Isothermal measurement protocols which allow correct assessment of the entropy change around first order phase transitions in both direct and inverse cases are presented.
Interaction of human hemoglobin (HHb) and cytochrome c (Cyt c) with biogenic chloroxine-conjugated silver nanoflowers: spectroscopic and molecular docking approaches
Creators: name: Shahabadi, Nahid
name: Zendehcheshm, Saba
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified

description: In this research, the biological activity of the antibacterial drug Chloroxine-conjugated biogenic AgNPs (COX-AgNPs) was investigated in simulated physiological conditions (pH = 7.40). Different spectroscopic methods such as UV–visible, fluorescence, and circular dichroism spectroscopic and docking simulation were employed to evaluate the structural changes in the most important blood proteins (human hemoglobin (HHb) and Cytochrome c (Cyt c)) in the presence of COX-AgNPs. The results showed that the COX-AgNPs can bind to HHb and Cyt c and the secondary structure of these proteins remains unchanged, which is crucial in providing insights into the side effects of newly synthesized drugs on their carriers. Communicated by Ramaswamy H. Sarma
Antivirals virtual screening to SARS-CoV-2 non-structural proteins
Creators: name: Nunes, Vinicius S.
name: Paschoal, Diego F. S.
name: Costa, Luiz Antônio S.
name: Dos Santos, Hélio F.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: In March 2020, the World Health Organization (WHO) declared coronavirus disease-19 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a pandemic. Since then, the search for a vaccine or drug for COVID-19 treatment has started worldwide. In this regard, a fast approach is the repurposing of drugs, primarily antiviral drugs. Herein, we performed a virtual screening using 22 antiviral drugs retrieved from the DrugBank repository, azithromycin (antibiotic), ivermectin (antinematode), and seven non-structural proteins (Nsps) of SARS-CoV-2, which are considered important targets for drugs, via molecular docking and molecular dynamics simulations. Drug–receptor binding energy was employed as the main descriptor. Based on the results, paritaprevir was predicted as a promising multi-target drug that favorably bound to all tested Nsps, mainly adipose differentiation-related protein (ADRP) (-36.2 kcal mol−1) and coronavirus main proteinase (Mpro) (-32.2 kcal mol−1). Moreover, the results suggest that simeprevir is a strong inhibitor of Mpro (-37.2 kcal mol−1), which is an interesting finding because Mpro plays an important role in viral replication. In addition to drug–receptor affinity, hot spot residues were characterized to facilitate the design of new drug derivatives with improved biological responses.
Anisotropic Dielectric Breakdown Strength of Single Crystal Hexagonal Boron Nitride
Creators: name: Hattori, Yoshiaki
name: Taniguchi, Takashi
name: Watanabe, Kenji
name: Nagashio, Kosuke
Publisher: name: arXiv
Year: 2016
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Dielectric breakdown has historically been of great interest from the perspectives of fundamental physics and electrical reliability. However, to date, the anisotropy in the dielectric breakdown has not been discussed. Here, we report an anisotropic dielectric breakdown strength (EBD) for h-BN, which is used as an ideal substrate for two-dimensional (2D) material devices. Under a well-controlled relative humidity, EBD values in the directions both normal and parallel to the c axis (EBD+c & EBD//c) were measured to be 3 and 12 MV/cm, respectively. When the crystal structure is changed from sp3 of cubic-BN (c-BN) to sp2 of h-BN, EBD+c for h-BN becomes smaller than that for c-BN, while EBD//c for h-BN drastically increases. Therefore, h-BN can possess a relatively high EBD concentrated only in the direction parallel to the c axis by conceding a weak bonding direction in the highly anisotropic crystal structure. This explains why the EBD//c for h-BN is higher than that for diamond. Moreover, the presented EBD value obtained from the high quality bulk h-BN crystal can be regarded as the standard for qualifying the crystallinity of h-BN layers grown via chemical vapor deposition for future electronic applications.
Adaptive FEM with coarse initial mesh guarantees optimal convergence rates for compactly perturbed elliptic problems
Creators: name: Bespalov, Alex
name: Haberl, Alexander
name: Praetorius, Dirk
Publisher: name: arXiv
Year: 2016
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 65N30, 65N12, 65N50

description: We prove that for compactly perturbed elliptic problems, where the corresponding bilinear form satisfies a Garding inequality, adaptive mesh-refinement is capable of overcoming the preasymptotic behavior and eventually leads to convergence with optimal algebraic rates. As an important consequence of our analysis, one does not have to deal with the a-priori assumption that the underlying meshes are sufficiently fine. Hence, the overall conclusion of our results is that adaptivity has stabilizing effects and can overcome possibly pessimistic restrictions on the meshes. In particular, our analysis covers adaptive mesh-refinement for the finite element discretization of the Helmholtz equation from where our interest originated.
Voltage dips in distribution systems : analysis and compensation by a D-UPFC
Creators: name: Rendroyoko, Ignatius
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
The forward-backward asymmetry for massive bottom quarks at the $Z$ peak at next-to-next-to-leading order QCD
Creators: name: Bernreuther, Werner
name: Chen, Long
name: Dekkers, Oliver
name: Gehrmann, Thomas
name: Heisler, Dennis
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We compute the order $α_s^2$ QCD corrections to the $b$-quark forward-backward asymmetry in $e^+e^-\to b{\bar b}$ collisions at the $Z$ boson resonance, taking the non-zero mass of the $b$ quark into account. We determine these corrections with respect to both the $b$-quark axis and the thrust axis definition of the asymmetry. We compute also the distributions of these axes with respect to the electron beam. If one neglects the flavor singlet contributions to the $b$-quark asymmetry, as was done in previous computations for massless $b$ quarks, then the second-order QCD corrections for $m_b\neq 0$ are smaller in magnitude than the corresponding corrections for $m_b=0$. Including the singlet contributions slightly increases the magnitude of the corrections. The massive $α_s^2$ corrections to the $b$-quark forward-backward asymmetry slightly diminish the well-known tension between the bare $b$-quark asymmetry and the standard model fit from $2.9σ$ to $2.6σ$.
description: Latex, 19 pages
MPEC 2023-L05 : 2023 KP5
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 KP5

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Targeting p53-MDM2 interactions to identify small molecule inhibitors for cancer therapy: beyond “Failure to rescue”
Creators: name: Chukwuemeka, Prosper Obed
name: Umar, Haruna Isiyaku
name: Iwaloye, Opeyemi
name: Oretade, Oluwaseyi Matthew
name: Olowosoke, Christopher Busayo
name: Elabiyi, Michael Omoniyi
name: Igbe, Festus Omotere
name: Oretade, Oyeyemi Janet
name: Eigbe, Joy Oseme
name: Adeojo, Funmilayo Janet
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: At present, disrupting p53-MDM2 interactions through small molecule ligands is a promising approach to safe treatment and management of human cancer. Tumor cells unlike the normal cells, are rapidly evolving affecting the efficacy of many approved anti-cancer agents due to drug resistance. Therefore, identifying a potential anticancer compound is crucial. Pharmacophore based virtual screening, followed by molecular docking, ADMET evaluation, and molecular dynamics studies against MDM2 protein was investigated to identify potential ligands that may act as inhibitors. The model (AHRR_1) with survival score (4.176) was selected among the top ranked generated Pharmacophore hypothesis. Validation of the model hypothesis by an external dataset of actives and inactive compounds produced significant validation attributes including; AUC = 0.85, BEDROC = 0.56 at α = 20.0, RIE = 8.18, AUAC = 0.88, and EF of 6.2 at the top 2% of the dataset. The model was use for screening the ZINC database, and the top 1375 hits satisfying the model hypothesis were subjected to molecular docking studies to understand the molecular and structural basis of selectivity of compounds for MDM2 protein. A sub-set of 25 compounds with binding energy lower than the reference inhibitors were evaluated for pharmacokinetic properties. Four compounds (ZINC02639178, ZINC06752762, ZINC38933175, and ZINC77969611) showed the most desired pharmacokinetic profile. Lastly, investigation of the dynamic behaviour of leads-protein complexes through MD simulation showed similar RMSD, RMSF, and H-bond occupancy profile compared to a reference inhibitor, suggesting stability throughout the simulation time. However, ZINC02639178 was found to satisfy the molecular enumeration the most compared to the other three leads. It may emerge as potential treatment option after extensive experimental studies. Communicated by Ramaswamy H. Sarma
How beaming of gravitational waves compares to the beaming of electromagnetic waves: impacts to gravitational wave detection
Creators: name: Miller, Andrew L.
name: Wickramasinghe, Thulsi
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We focus on understanding the beaming of gravitational radiation from gamma ray bursts (GRBs) by approximating GRBs as linearly accelerated point masses. For accelerated point masses, it is known that gravitational radiation is beamed isotropicly at high speeds, and beamed along the polar axis at low speeds. Aside from this knowledge, there has been very little work done on beaming of gravitational radiation from GRBs, and the impact beaming could have on gravitational wave (GW) detection. We determine the following: (1) the observation angle at which the most power is emitted as a function of speed, (2) the maximum ratio of power radiated away as a function of speed, and (3) the angular distribution of power ratios at relativistic and non-relativistic speeds. Additionally the dependence of the beaming of GW radiation on speed is essentially the opposite of the beaming of electromagnetic (EM) radiation from GRBs. So we investigate why this is the case by calculating the angular EM radiation distribution from a linear electric quadrupole, and compare this distribution to the angular gravitational radiation distribution from a GRB.
description: Conference proceeding for 11th Edoardo Amaldi Conference on Gravitational Waves
CFS : constraint programming in multiple domains
Creators: name: Rendell, Robert P.
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Binding mode characterization of 13b in the monomeric and dimeric states of SARS-CoV-2 main protease using molecular dynamics simulations
Creators: name: Kumari, Anita
name: Mittal, Lovika
name: Srivastava, Mitul
name: Asthana, Shailendra
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The main protease, Mpro/3CLpro, plays an essential role in processing polyproteins translated from viral RNA to produce functional viral proteins and therefore serve as an attractive target for discovering COVID-19 therapeutics. The availability of both monomer and dimer crystal bound with a common ligand, ‘13b’ (α-ketoamide inhibitor), opened up opportunities to understand the Mpro mechanism of action. A comparative analysis of both forms of Mpro was carried out to elucidate the binding site architectural differences in the presence and absence of ‘13b’. Molecular dynamics simulations suggest that the presence of ‘13b’ enhances the stability of Mpro than the unbound APO form. The N- and C- terminals of both the protomers stabilize each other, and making it's interface essential for the active form of Mpro. In comparison to monomer, the relatively high affinity of ‘13b’ is gained in dimer pocket due to the high stability of the pocket by the interaction of S1 residue of chain B with residues F140, E166 and H172 of chain A, which is absent in monomer. The comprehensive essential dynamics, protein structure network analysis and thermodynamic profiling highlight the hot-spots, pivotal in molecular recognition process at protein-ligand and protein-protein interaction levels, cross-validated through computational alanine scanning study. A comparative description of ‘13b’ binding mechanism in both forms illustrates valuable insights into the inhibition mechanism and the selection of critical residues suitable for the structure-based approaches for the identification of more potent Mpro inhibitors. Communicated by Ramaswamy H. Sarma
Panchromatic Spectral Energy Distributions of simulated galaxies: results at redshift $z=0$
Creators: name: Goz, David
name: Monaco, Pierluigi
name: Granato, Gian Luigi
name: Murante, Giuseppe
name: Domínguez-Tenreiro, Rosa
name: Obreja, Aura
name: Annunziatella, Marianna
name: Tescari, Edoardo
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present predictions of Spectral Energy Distributions (SEDs), from the UV to the FIR, of simulated galaxies at $z=0$. These were obtained by post-processing the results of an N-body+hydro simulation of a small cosmological volume, that uses the Multi-Phase Particle Integrator (MUPPI) for star formation and stellar feedback, with the GRASIL-3D radiative transfer code, that includes reprocessing of UV light by dust. Physical properties of galaxies resemble observed ones, though with some tension at small and large stellar masses. Comparing predicted SEDs of simulated galaxies with different samples of local galaxies, we find that these resemble observed ones, when normalised at 3.6 $μ$m. A comparison with the Herschel Reference Survey shows that, when binning galaxies in Star Formation Rate (SFR), average SEDs are reproduced to within a factor of $\sim2$ even in normalization, while binning in stellar mass highlights the same tension that is present in the stellar mass -- SFR plane. We use our sample to investigate the correlation of IR luminosity in Spitzer and Herschel bands with several galaxy properties. SFR is the quantity that best correlates with IR light up to $160\ μ$m, while at longer wavelengths better correlations are found with molecular mass and, at $500\ μ$m, with dust mass. However, using the position of the FIR peak as a proxy for cold dust temperature, we assess that heating of cold dust is mostly determined by SFR, with stellar mass giving only a minor contribution. We finally show how our sample of simulated galaxies can be used as a guide to understand the physical properties and selection biases of observed samples.
description: 18 pages, 11 figures, Submitted to MNRAS
The forces upon an elastically mounted rigid circular cylinder exposed to combined steady and planar oscillatory flows
Creators: name: Reid, David Leonard
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.