cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
X-ray outburst of CI Cam/XTE J0421+560: RXTE observations
Creators: name: Revnivtsev, M.
name: Emelyanov, A.
name: Borozdin, K.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present the results of observations of XTE J0421+560 X-ray transient with Rossi X-ray Timing Explorer in the beginning of April 1998. Lightcurve, obtained by ASM all-sky monitor, shows unusually fast decrease in the object's luminosity. Spectra from series of observations by PCA and HEXTE experiments were studied in detail. Two emission line regions with energies around 6.5 keV and around 8 keV have been mentioned in the spectra. The possibility of generation of the observed emission in relativistic plasma jet has been discussed. Some analogy is found with known Galactic jet source SS433.
description: 27 pages, 10 figures. Astronomy Letters, 1999, v.25, n.5, p.350-363
Metabolic phenotype analysis in patients with pulmonary hypertension
Creators: name: Ghataorhe, Pavandeep Kaur
Publisher: name: Imperial College London
Year: 2016

description: Pulmonary hypertension (PH) is a heterogeneous and progressive disorder leading to right ventricular dysfunction, and carries significant mortality. Diagnosis requires invasive cardiac catheterisation and the pathogenesis of the vascular biology is poorly understood. Metabolic dysregulation has been implicated in PH but there have been no high-throughput analyses of circulating metabolites in these patients. Using nuclear magnetic resonance spectroscopy, abnormal plasma metabolite levels were identified in patients with pulmonary arterial hypertension (PAH), relating to energy metabolism and lipid regulation, with decreased large high-density lipoprotein subtypes associated with poor survival. These findings were expanded using unbiased ultra-performance liquid chromatography mass spectrometry methodologies (including lipidomics), which identified novel changes including increased circulating fatty acid acylcarnitines and reduced sphingomyelins and phosphocholines. To extend the identification of metabolites, samples were also analysed using a commercial metabolomics approach. Semi-quantitative assessment of 1416 metabolites in three cohorts of PAH patients identified metabolites that discriminated PAH patients from controls. These included increased levels of tRNA-specific modified nucleosides, tricarboxylic acid (TCA) cycle intermediates, glutamate, tryptophan and polyamine metabolites and decreased levels of steroids metabolites. The largest differences correlated with increased risk of death and correction of several metabolites over time was associated with better outcomes. Patients who responded to calcium channel blocker therapy had metabolic profiles similar to healthy controls. Metabolic profiling also discriminated patients with other sub-diagnoses of PH from controls. Variant-metabolite associations published in control populations were validated in PAH patients using data from whole genome sequencing. Mendelian randomisation studies found that these variants did not relate to outcomes in PAH. In conclusion, this study comprehensively describes metabolic abnormalities in patients with PAH and demonstrates alterations in pathophysiologically-relevant metabolites. Metabolic profiles are strongly related to outcomes and may be used to distinguish patients with poor prognosis or response to therapy and identify potential therapeutic targets.
Droplets: from molecular nanoclusters to atmospheric aerosols
Creators: name: Lau, Gabriel
Publisher: name: Imperial College London
Year: 2016

description: Atmospheric aerosols play a key role in affecting climate, pollution and human health by in- fluencing the properties and lifetimes of clouds and precipitation. Despite this, the molecular mechanisms involved in the nucleation of nanoscale liquid droplets are not yet fully under- stood. In this thesis, we attempt to gain a better understanding of the surface properties and small-scale thermodynamics of nanoscopic clusters of water using molecular dynam- ics simulation to complement the recent surge of scientific interest in atmospheric aerosol nucleation. Existing literature is reviewed on simulation techniques to obtain the surface tension of planar and curved interfaces, as well as studies on vapour-liquid nucleation. This is followed by several in-depth computational investigations into the surface properties of water. In the first, we apply a free-energy perturbation technique, namely the test-area (TA) method, to compute the surface tension of planar, cylindrical and spherical geometries of water. In addition, a mathematical analysis of the TA method is carried out, revealing further insight into the underlying features of perturbation methods as well as their limi- tations. The results are compared to previous literature and the differences discussed. In the second and third, the excess free energy is obtained for small clusters of water using an extension of a non-equilibrium disassembly method originally developed for studies on argon clusters. The results are used to construct free-energy curves that are subsequently fed into classical rate expressions and compared to experimental values. In the final part of the thesis, the formalism generalising the cluster disassembly method to multi-component systems is presented.
The Excess Density of Field Galaxies near z=0.56 around the Gamma-Ray Burst GRB021004 Position
Creators: name: Sokolov, I. V.
name: Castro-Tirado, A. J.
name: Zhelenkova, O. P.
name: Solovyev, I. A.
name: Verkhodanov, O. V.
name: Sokolov, V. V.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We test for reliability any signatures of field galaxies clustering in the GRB 021004 line of sight. The first signature is the GRB 021004 field photometric redshifts distribution based on the 6-m telescope of the Special Astrophysical Observatory of the Russian Academy of Sciences observations with a peak near z = 0.56 estimated from multicolor photometry in the GRB direction. The second signature is the Mg II 2796, 2803AA absorption doublet at z = 0.56 in VLT/UVES spectra obtained for the GRB 021004 afterglow. The third signature is the galaxy clustering in a larger (of about 3 sq.deg.) area around GRB 021004 with an effective peak near z = 0.56 for both the spectral and photometric redshifts from a few catalogs of clusters based on the Sloan Digital Sky Survey (SDSS) and Baryon Oscillation Spectroscopic Survey (BOSS) as a part of SDSS-III. From catalog data the size of the whole inhomogeneity in distribution of the galaxy cluster with the peak near z = 0.56 was also estimated as about 6--8 deg. or 140--190 Mpc. A possibility of inhomogeneity (a galaxy cluster) near the GRB 021004 direction can be also confirmed by an inhomogeneity in cosmic microwave background related with the Sunyaev-Zeldovich effect.
description: 23 pages, 13 figures
Additional file 4: of Differential effects of Nintedanib and Pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis
Creators: name: Lehmann, Mareike
name: Buhl, Lara
name: Alsafadi, Hani
name: Klee, Stephan
name: Hermann, Sarah
name: Mutze, Kathrin
name: Ota, Chiharu
name: Lindner, Michael
name: Behr, Jürgen
name: Hilgendorff, Anne
name: Wagner, Darcy
name: Königshoff, Melanie
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Figure S4. Effect of Pirfenidone on ex vivo human PCLS model of IPF. (A-C) Punches were treated with CC/FC and Pirfenidone (500 μM) as indicated in (Fig. 4a). (A) Metabolic activity of punches 120h after treatment with CC/FC and cotreatment with Pirfenidone. N = 3. Significance was assessed by two-way ANOVA followed by Sidak’s multiple comparisons test. (B) Gene expression analysis by qPCR of epithelial cell marker SFTPC, NKX2.1, CDH-1, ZO-1. ΔΔCt is presented as mean ± SEM, n = 3. Means were compared to respective DMSO control using one-sample t-tests in comparison to a hypothetical value of 0. (C) SP-C secretion was measured by ELISA. Shown are values normalized to CC without Pirfenidone. Significance was assessed using Wilcoxon matched pairs test. N = 6. (PDF 97 kb)
Charge emissions from Electrosprays in vacuum: mixtures of formamide with methylammonium formate
Creators: name: Garoz, David
name: de la Mora, Juan Fernández
Publisher: name: arXiv
Year: 2024
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: The charge/mass distribution f(q/m) of nanodrops and ions electrosprayed in vacuum from mixtures of formamide (FM) and methylammonium formate (MAF) is studied by time of flight mass spectrometry at MAF/FM volumetric concentrations of 5%, 10%, 25% and 50%. Positive and negative polarities yield comparable f(q/m) curves, though the negative mode yields ~30% larger currents. On shifting from the highest to the lowest liquid flow rates, at which a cone-jet is stable, the more conducting solutions evolve from mostly drop to primarily ion emission. A purely ionic regime is not reached under any condition, but the drops achieve unusually high q/m. As a result, these sprays have excellent electrical propulsion characteristics, some being able to cover a 25-fold range of average q/m with a propulsive efficiency typically in the range of 80%. Results of formamide electrolytes with formates and nitrates of several other amines are more briefly reported.
Radio to Gamma-Ray Emission from Shell-type Supernova Remnants: Predictions from Non-linear Shock Acceleration Models
Creators: name: Baring, Matthew G.
name: Ellison, Donald C.
name: Reynolds, Stephen P.
name: Grenier, Isabelle
name: Goret, Philippe
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Supernova remnants (SNRs) are widely believed to be the principal source of galactic cosmic rays. Such energetic particles can produce gamma-rays and lower energy photons via interactions with the ambient plasma. In this paper, we present results from a Monte Carlo simulation of non-linear shock structure and acceleration coupled with photon emission in shell-like SNRs. These non-linearities are a by-product of the dynamical influence of the accelerated cosmic rays on the shocked plasma and result in distributions of cosmic rays which deviate from pure power-laws. Such deviations are crucial to acceleration efficiency and spectral considerations, producing GeV/TeV intensity ratios that are quite different from test particle predictions. The Sedov scaling solution for SNR expansions is used to estimate important shock parameters for input into the Monte Carlo simulation. We calculate ion and electron distributions that spawn neutral pion decay, bremsstrahlung, inverse Compton, and synchrotron emission, yielding complete photon spectra from radio frequencies to gamma-ray energies. The cessation of acceleration caused by the spatial and temporal limitations of the expanding SNR shell in moderately dense interstellar regions can yield spectral cutoffs in the TeV energy range; these are consistent with Whipple's TeV upper limits on unidentified EGRET sources. Supernova remnants in lower density environments generate higher energy cosmic rays that produce predominantly inverse Compton emission at super-TeV energies; such sources will generally be gamma-ray dim at GeV energies.
description: 62 pages, AASTeX format, including 1 table and 11 figures, accepted for publication in The Astrophysical Journal (Vol 513, March 1, 1999)
Quantitative evaluation of ultrasonic techniques for the detection and monitoring of corrosion in pipes
Creators: name: Howard, Richard David
Publisher: name: Imperial College London
Year: 2017

description: Corrosion of the oil and gas pipeline infrastructure has the potential to lead to catastrophic consequences, including loss of life. By performing continual diagnostic non-destructive evaluation (NDE) assessments of the pipeline infrastructure, corrosion can be tracked, mitigated and controlled. However, the sheer scale of the modern pipeline networks around the world requires new innovative techniques to efficiently and cost-effectively monitor and screen for corrosion. Currently there are two well-established ultrasonic techniques for monitoring and screening corrosion. Spot measurements extract the pipe wall thickness at a single point location. This method can extract an accurate value of wall thickness, but the measurement is highly localised. In contrast, long range guided waves (LRGWs) screen for damage by exciting a pulse which travels axially down a pipe and will reflect off any large areas of corrosion. This method has a large coverage area, but is much less sensitive to corrosion than the spot measurement techniques. The first part of this thesis explores the sensitivity of a circumferential guided wave technique, which is suggested to mitigate against some of the disadvantages of existing methodologies. This method propagates a guided wave around the circumference of a pipe, and uses either the reflected pulse from the defect or the through transmitted pulse, to detect the presence of a defect. The viability of this method was assessed by modelling the ultrasonic response to a range of different defects and using probabilistic techniques. The S0, SH1 and SH0 modes were studied and it was revealed that in reflection the technique is able to detect narrow and deep defects, whereas in transmission wide defects are detectable. Wavelength normalised results are also presented. The second part of this thesis investigates the interaction between spot measurement (shear bulk waves) and hemispherical pits. This is with a view to further understanding the mechanics behind the interaction between shear waves and pitting corrosion, and to assessing current transducer types to the tracking and monitoring of individual pits. It was found that an anisotropic relationship exists between the pit’s location relative to the shearing direction of the bulk wave. This is due to either the inherent anisotropy of the transducer or the mode conversion of the shear wave.
Additional file 1: of What information and the extent of information research participants need in informed consent forms: a multi-country survey
Creators: name: Juntra Karbwang
name: Nut Koonrungsesomboon
name: Torres, Cristina
name: Edlyn Jimenez
name: Kaur, Gurpreet
name: Mathur, Roli
name: Sholikhah, Eti
name: Chandanie Wanigatunge
name: Chih-Shung Wong
name: Kwanchanok Yimtae
name: Murnilina Abdul Malek
name: Liyana Ahamad Fouzi
name: Aisyah Ali
name: Beng Chan
name: Madawa Chandratilake
name: Shoen Chiew
name: Chin, Melvyn
name: Manori Gamage
name: Gitek, Irene
name: Hakimi, Mohammad
name: Narwani Hussin
name: Mohd Jamil
name: Pavithra Janarsan
name: Madarina Julia
name: Kanungo, Suman
name: Panduka Karunanayake
name: Sattian Kollanthavelu
name: Kong, Kian
name: Kueh, Bing-Ling
name: Kulkarni, Ragini
name: Kumaran, Paul
name: Kumarasiri, Ranjith
name: Lim, Wei
name: Lim, Xin
name: Fatihah Mahmud
name: Mantaring, Jacinto
name: Siti Md Ali
name: Nurain Mohd Noor
name: Kopalasuntharam Muhunthan
name: Elanngovan Nagandran
name: Maisarah Noor
name: Ooi, Kim
name: Jebananthy Pradeepan
name: Sadewa, Ahmad
name: Nilakshi Samaranayake
name: Ranganathan, Shalini Sri
name: Wasanthi Subasingha
name: Sivasangari Subramaniam
name: Sulaiman, Nadirah
name: Tay, Ju
name: Leh Teng
name: Tew, Mei
name: Thipaporn Tharavanij
name: Tok, Peter
name: Jayanie Weeratna
name: Wibawa, Tri
name: Wickremasinghe, Renu
name: Phanthipha Wongwai
name: Yadav, Subhash
Publisher: name: figshare
Year: 2018
Subjects: subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Table S1. The proportions of the respondents who wanted to know each element. (DOCX 20 kb)
Supplemental file for the publication "Detection of bovine milk adulteration in caprine milk with N-acetyl carbohydrate biomarkers by using 1H nuclear magnetic resonance spectroscopy"
Creators: name: Lucie, Rysova
name: Veronika, Legarova
name: Zuzana, Pacakova
name: Oto, Hanus
name: Irena, Nemeckova
name: Marcela, Klimesova
name: Jaroslav, Havlik
Publisher: name: Zenodo
Year: 2021
Subjects: biomarker
caprine milk
food authenticity
nuclear magnetic resonance

description: Supplemental file S1 for the publication "Detection of bovine milk adulteration in caprine milk with N-acetyl carbohydrate biomarkers by using 1H nuclear magnetic resonance spectroscopy" contains: 1) Table 1. Arithmetic mean, standard error, minimum and maximum of peaks integral values of N-acetyl carbohydrates. 2) Table 2. P(corr) values generated from OPLS-DA performed on peaks integral values of four major biomarkers of bovine milk and related cross-validated R2Y and Q2 coefficients with P-value from random permutation test based on 1000 permutations processed for five different pairs in relation to the percentage of adulteration. 3) Table 3. The evaluation of utility of N-acetyl carbohydrate signal for the detection of caprine milk adulterated by bovine milk by blind test according to the formula mentioned by Dalabasmaz et al. (2019).
title: ADCO, Ordre cistercien et abbaye de Cîteaux : comptes pour l'ordre (1337-1347), comptes du boursier (1377-1402) (11 H 1160), f. 00407
Creators: name: de la Côte-d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2017
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: comptes
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Ordre cistercien et abbaye de Cîteaux : comptes pour l'ordre (1337-1347), comptes du boursier (1377-1402), Archives départementales de la Côte-d'Or, (11 H 1160). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Ordre cistercien et abbaye de Cîteaux : comptes pour l'ordre (1337-1347), comptes du boursier (1377-1402), Archives départementales de la Côte-d'Or, (11 H 1160), f. 00407, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Additional file 1: of Sustaining knowledge translation interventions for chronic disease management in older adults: protocol for a systematic review and network meta-analysis
Creators: name: Tricco, Andrea
name: Moore, Julia
name: Beben, Nicole
name: Brownson, Ross
name: Chambers, David
name: Dolovich, Lisa
name: Edwards, Annemarie
name: Fairclough, Lee
name: Glasziou, Paul
name: Graham, Ian
name: Hemmelgarn, Brenda
name: Holmes, Bev
name: Wanrudee Isaranuwatchai
name: Lachance, Chantelle
name: Legare, France
name: McGowan, Jessie
name: Majumdar, Sumit
name: Presseau, Justin
name: Squires, Janet
name: Stelfox, Henry
name: Strifler, Lisa
name: Thompson, Kristine
name: Weijden, Trudy Van Der
name: Veroniki, Areti
name: Straus, Sharon
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: PRISMA-P 2015 Checklist. Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) 2015 statement. (DOCX 30 kb)
Charadrius spinosus Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Charadriiformes
Charadriidae
Charadrius
Charadrius spinosus

description: Charadrius spinosus [spec. nov.]
C. remigibus pectore abdomine pedibusque atris, rectricibus dimidiato-albis, humeris spinosis.
Charadrius spinosus. Hasselq. itin. 260. 270.
Habitat in Aegypto.
Humeri spinosi, ut in Fulica spinosa, singulares sunt.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 151, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
A multistage stochastic modelling framework for the optimal operation of DER aggregators under multidimensional uncertainty using stochastic dual dynamic programming
Creators: name: Fatouros, Panagiotis
Publisher: name: Imperial College London
Year: 2017

description: The emerging paradigm shift towards the Smart Grid concept, has vigorously encouraged the broad deployment of distributed energy resources (DER), such as energy storage (ES) and flexible demand (FD) and renewable micro-generators, in the energy system. In deregulated power systems, the deployment of flexibility pertaining to ES and FD is associated with their efficient integration in the electricity market. However, significant participation barriers have triggered the introduction of distributed energy resources (DER) aggregators in electricity markets, which settle the necessary framework for the market realisation of their promising operational flexibility potential. The significant number and diversity of resources pertaining to the DER aggregator portfolio, combined with multiple stochastic components affecting its optimal operation demonstrate a high-dimensional stochastic problem. Existing literature focusing on the problem of the optimal operation of DER aggregators exhibits significant limitations, since two-stage stochastic formulations are adopted. In this context, this thesis proposes, analyses and evaluates a novel multistage stochastic model, where multidimensional stochasticity is efficiently considered. Suitable dimensionality reduction and decomposition techniques have been deployed to tackle the computational issues stemming from the high dimensionality of the problem. Stochastic Dual Dynamic programming (SDDP) is deployed to alleviate computational tractability problems. Autoregressive models (AR) are employed to articulate temporal and cross-variable dependencies among the stochastic variables. Two novel extensions of the traditional SDDP algorithm, where linear (i.e. AR) models are integrated in the solution process and enhance solution quality, are proposed. A simulation framework for the validation and assessment of the proposed extended SDDP models, which compares them against scenario tree formulations with different structural characteristics, is presented. Case studies demonstrate that the extended SDDP models achieve a better trade-off between solution efficiency and computational performance. Additionally, results highlight the value of strategic positioning of the DER aggregator portfolio, when limited renewable generation is available. Finally, the effect of strategic decision-making based on less accurate information is shown to be intensified when the aggregator manages a more flexible portfolio.
Molecular Gas in 3C 293: The First Detection of CO Emission and Absorption in an F-R II Radio Galaxy
Creators: name: Evans, A. S.
name: Sanders, D. B.
name: Surace, J. A.
name: Mazzarella, J. M.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The first detection of CO emission in a Fanaroff-Riley Class II (i.e., edge-brightened radio morphology) radio galaxy is presented. Multi- wavelength (0.36-2.17 micron) imaging of 3C 293 shows it to be a disk galaxy with an optical jet or tidal tail extending towards what appears to be a companion galaxy 28 kpc away via a low surface brightness envelope. The molecular gas appears to be distributed in an asymmetric disk rotating around an unresolved continuum source, which is presumably emission from the AGN. A narrow (approx 60 km/s) absorption feature is also observed in the CO spectrum and is coincident with the continuum source. Using the standard CO conversion factor, the molecular gas mass is calculated to be 1.5x10^10 M_sun, several times the molecular gas mass of the Milky Way. The high concentration of molecular gas within the central 3 kpc of 3C 293, combined with the multiwavelength morphological peculiarities, support the idea that the radio activity has been triggered by a gas-rich galaxy-galaxy interaction or merger event.
description: LaTex, 8 pages with 2 postscript and 2 jpg figures, ApJ, in press
Metabolic profiling in cholangiocarcinoma
Creators: name: Alsaleh, Munira
Publisher: name: Imperial College London
Year: 2017

description: Throughout this thesis, metabolic profiling using a global mass spectrometry-based approach was utilised to explore cholangiocarcinoma (CCA) metabolic signature in urine and serum. CCA is an aggressive disease with a poor prognosis. The geographical distribution of CCA cases is markedly uneven and it closely mirrors the prevalence of its predisposing risk factors. CCA is most commonly seen in Southeast Asia where liver fluke infection is endemic, whereas in Western countries it is a rare malignancy with an unknown aetiology in most cases. To date, a multi-disciplinary approach with multi-modal tools are often applied for the diagnosis of this complex disease. The primary aim of this thesis was to provide insights into the perturbed biological pathways underlying cholangiocarcinogenesis as a mean to identify metabolite biomarkers to improve CCA screening and diagnosis. The first four results chapters describes the urinary metabolome associated with liver fluke induced-CCA and sporadic CCA in patients from Thailand and the UK, respectively. Overall, CCA induces a metabolic profile change that can distinguish patients from healthy and control groups with various hepatobiliary pathologies. Dysregulation in acylcarnitine, bile acid, steroid and purine metabolism was characteristic of the CCA urinary metabolic signature in both populations. A panel of 10 metabolites (primarily acylcarnitine and steroid species) achieved a diagnostic accuracy of 93.4% and AUC value of 98.8% (CI= 96.3%-100%) in distinguishing CCA cases from healthy participants. Phenotypic disparities between the two distinct populations were primarily related to differences in dietary practices and body composition. Furthermore, regardless of the underlying aetiology, biological perturbations associated with the CCA urine metabolome signature appeared to be influenced by gut microbial community metabolism. Sporadic bile duct disease exhibited altered nucleotide metabolism, possibly indicating differences in mitochondrial energy production pathways related to differences in CCA underlying aetiology. Similarly, the serum metabolic patterns were differential in bile duct cancer, compared to healthy participants and individuals with benign and malignant hepatobiliary diseases. Impaired phospholipid homoeostases was particularly observed in CCA serum profiles, possibly suggesting influence of genetic variants that impair biliary phospholipid secretion on circulating lipids. A common metabotype, primarily indicative of inflammatory signature, was found to be associated with liver pathologies, both benign and malignant. Overall, it is possible to conclude that metabonomic profiling can identify disease-related metabotypes and may possibly contribute to uncovering novel candidate diagnostic biomarkers in CCA.
Towards a more controllable sensorised soft gripper: a data-driven approach
Creators: name: Elgeneidy, Khaled
Publisher: name: Loughborough University
Year: 2021
Subjects: subject: 91399 Mechanical Engineering not elsewhere classified
subject: FOS: Mechanical engineering

description: Robotic grippers have been constantly improving over the years to become more dextrous and adaptable in handing difficult objects with variations in their shape or uncertainty in their positioning. A challenge that remains difficult until now is the ability to handle delicate objects that can be easily considered as defective due to their interaction with the gripper, such as the case for food products or finely machined parts. An interesting emerging approach to tackle this challenge is to rethink the origin of the problem, which is the fact that all conventional grippers are made of hard and rigid components that can easily damage objects during grasping if not precisely controlled based on reliable sensory feedback. Hence, creating gripper fingers from soft materials makes them inherently safe and relaxes the need for sophisticated sensing and complex control. However, several open research challenges exist that are hindering the full utilisation of soft robotic components. In the context of soft grippers, relying primarily on the soft nature of the fingers to passively and gently adapt to its targets although highly desirable, consequently means that no sensory feedback is available to have better control over the grasping process or confirm its success.In this research, a low-cost soft gripper was developed based on the ribbed pneumatic bending actuators with embedded bend sensing, in order to investigate the potential for sensor-guided control of soft gripper fingers. [Continues.]
Designing metainterfaces with specified friction laws
Creators: name: Aymard, Antoine
name: Delplanque, Emilie
name: Dalmas, Davy
name: Scheibert, Julien
Publisher: name: arXiv
Year: 2024
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Classical Physics (physics.class-ph)
subject: FOS: Physical sciences

description: Many devices, including touchscreens and robotic hands, involve frictional contacts. Optimizing these devices requires fine control of the interface's friction law. We lack systematic methods to create dry contact interfaces whose frictional behavior satisfies preset specifications. We propose a generic surface design strategy to prepare dry rough interfaces that have predefined relationships between normal and friction forces. Such metainterfaces circumvent the usual multiscale challenge of tribology by considering simplified surface topographies as assemblies of spherical asperities. Optimizing the individual asperities' heights enables specific friction laws to be targeted. Through various centimeter-scaled elastomer-glass metainterfaces, we illustrate three types of achievable friction laws, including linear laws with a specified friction coefficient and unusual nonlinear laws. This design strategy represents a scale- and material-independent, chemical-free pathway toward energy-saving and adaptable smart interfaces.
description: Accepted version, including main text and Supplementary Materials
Betatron radiation from laser wakefield accelerators and its applications
Creators: name: Wood, Jonathan
Publisher: name: Imperial College London
Year: 2016

description: This thesis will detail experimental research in to laser wakefield acceleration (LWFA), with a particular focus on LWFA's as compact sources of brilliant, hard synchrotron radiation, so-called betatron radiation. The first results presented are from an experiment where a ~10 TW laser pulse was focussed in to a clustered methane target. The presence of clusters enhanced the stability and tunability of the electron beam while maintaining similar electron beam peak energies and charges to other injection mechanisms. It also produced beams with three times larger transverse momentum in the laser polarisation direction, differentiating this injection mechanism from self- and ionisation-injection as well as hinting at a possible future use as a reliable source of polarised betatron radiation. The primary result of this thesis follows, which is that a self-injecting, self-guided LWFA driven by a 100-200 TW laser pulse, with a long f/40 focussing geometry, showed an increase in betatron brightness to 2.8x10^24 photons/s/mm^2/mrad^2/0.1%BW, the highest brightness betatron source yet reported, along with a source size of approximately 300 nm inferred from spectral measurements of the almost 2 GeV electron beams and ~20 keV critical energy betatron x-ray beams. At longer acceleration lengths an additional, large injection of charge in to the wakefield dramatically increased the photon yield at moderate energies by a factor of 5-6. The final result is the first demonstration that betatron radiation is suitable for imaging rapidly evolving phenomena. By studying shock propagation in solid density targets it will be shown that it can be used to qualitatively and quantitatively study the properties of the shock. It is shown that with the reported increase in photon number, betatron radiation can produce images of rapidly evolving phenomena of comparable quality to those taken in recent experiments at third and fourth generation light sources.
Additional file 3: of Differential effects of Nintedanib and Pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis
Creators: name: Lehmann, Mareike
name: Buhl, Lara
name: Alsafadi, Hani
name: Klee, Stephan
name: Hermann, Sarah
name: Mutze, Kathrin
name: Ota, Chiharu
name: Lindner, Michael
name: Behr, Jürgen
name: Hilgendorff, Anne
name: Wagner, Darcy
name: Königshoff, Melanie
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: Figure S3. Effect of Pirfenidone and Nintedanib on epithelial cell marker in non-fibrotic 3D-LTCs ex vivo (A-C) Fibrotic and non-fibrotic 3D-LTCs were cultured for 48h in the presence of anti-fibrotic drugs Nintedanib (1μM) and Pirfenidone (500μM). (A) proSP-C expression was assessed by Western blot. β-Actin was used as loading control. Quantification of proSP-C Western blot. Data was normalized to β-Actin. Significance was assessed using Wilcoxon matched pairs test, n = 6. (B, C) SP-C and WISP 1 secretion of non-fibrotic 3D-LTCs was determined by ELISA. Significance was assessed using Wilcoxon matched pairs test, n = 4-7. (D) Fibrotic and non-fibrotic 3D-LTCs were cultured for 48h in the presence of 2.5mM Pirfenidone. Gene expression analysis by qPCR of ATII marker Sftpc. ΔCt is presented as mean ± SEM, n = 5. Means were compared using repeated-measures one-way ANOVA followed by Newmann-Keuls post test. Significance: *p
Analysis for sensing resource reduction via state evolution
Creators: name: Lu, Yang
Publisher: name: Imperial College London
Year: 2017

description: This thesis focuses on the approximate message passing (AMP) based algorithms for solving compressed sensing problems and provides corresponding modifications and state evolution analyses based on the following situations. We consider the correlated distributed compressed sensing (C-DCS) model, in which multiple measurement instances are included. This model allows correlation between measurement matrices and signals across different measurement instances. We modified the AMP algorithm for the C-DCS model such that it can handle correlated matrices and correlated signals. Correctness justification is provided for our proposed algorithm for two special cases: distributed compressed sensing (DCS) and multiple measurement vectors (MMV) models. Simulations show that the empirical results almost perfectly match the theoretical predictions achieved by state evolution. We consider a practical signal transmission/receiving application with fixed energy budget and assume that the thermal noise is the dominant noise source. Under such conditions, we observe that the overall signal-to-noise ratio (SNR) per measurement decreases quadratically with the increase of the number of measurements. By applying the AMP algorithm and state evolution analysis, we are able to provide an optimal number of measurements to minimize the mean squared error of the estimate which is different from the common wisdom where more measurements often mean a better performance. Numerical results justify the correctness of our analysis. The performance of AMP may severely deteriorate when the measurement matrix is not a standard Gaussian random matrix. We propose an improved AMP (IAMP) algorithm that works better for non i.i.d. Gaussian random matrices when the correlations between elements of the measurement matrix deviate from those of the standard Gaussian. The derivation is based on a modification of the message passing mechanism that removes the conditional independence assumption. Examples are provided to demonstrate the performance improvement of IAMP where both a particularly designed matrix and a matrix from real applications are used.
Understanding the deformation mechanisms of CVD alpha-alumina coatings
Creators: name: Giovannini, Tommaso
Publisher: name: Imperial College London
Year: 2018

description: The mechanical performance of metal cutting tools has improved considerably since the industry started to adopt ceramic coatings deposited via physical (PVD) and chemical vapour deposition (CVD). Further improvements in cutting tool performance are therefore contingent on the improved mechanical performance of these coatings. These developments require a thorough understanding of the micromechanical mechanisms in operation during metal cutting operations, with specific emphasis on plastic deformation of the coatings, and how it affects overall tool performance. To investigate the plastic deformation behaviour of the coating materials, an experimental characterisation on commonly used CVD α-Al2O3 and Ti(C,N) coatings was performed. This investigation started with electron back scattered diffraction (EBSD) measurements of the different coatings to allow for measurement of their crystallographic texture. These measurements were complemented by high temperature (300°C) nanoindentation measurements. Micropillar compression experiments were also performed to probe the critical resolved shear stress of the active plastic deformation systems in the α-Al2O3 coatings. Combined, these investigations allowed to understand the effect of crystallographic orientation and high temperatures on the coating deformation behaviour. To complement the experimental characterization of the coating materials, development of a modelling framework, based on planar discrete dislocation plasticity theory, was also initiated. A fundamental input quantity of the modelling framework is known as the dislocation drag coefficient which is used to govern the mobility of plastic defects during simulations. An experimental framework, based on the micropillar compression of Zr-4 micropillars, was developed to evaluate the feasibility of rapid experimental measurement of the quantity.
Dynamics and control assessment for complex processes: a study of fuel-flexible syngas shifting and gasification
Creators: name: Narvaez-Cueva, Ricardo
Publisher: name: Loughborough University
Year: 2021
Subjects: subject: 91399 Mechanical Engineering not elsewhere classified
subject: FOS: Mechanical engineering

description: This thesis presents a model-based controlling proposal for a pilot-scale gasifier with passive syngas shifting components. This control proposal was developed out of a prior dynamic modelling stage and validation of the technological improvements.
The first element was the validation of the technology improvement which consisted of an energy-passive, packed-bed structure located in the upper part of the gasifier that removed CO2 from syngas and promoted water-gas shifting. The validation consisted of performing experimental assays with and without the packed-bed structure. Results show that this structure enhanced the cold gas efficiency (CGE) between 24.46% and 40.48%, depending on the inlet air O2 content.
The second component was related to the feedstock quality-dependent dynamic modelling of municipal solid waste (MSW) gasification. The modelling approach consisted of a hybrid/ grey box-type model, formed by a transfer function-type structure whose parameters were calculated out of feedstock quality and dynamic operational variables by an ANN-based component. The variables were previously evaluated by feature selection. The results indicated that air flow rate, sulphur content of feedstock, and syngas recirculation flow rate were the most influential attributes.
The third component was the development of a self-tuneable proportional, integrative, derivative (PID)-based control loop. The novelty included the dynamic modelling approach of the second component for generating feedstock quality-dependent transfer functions. Results showed that settling time was reduced in up to 21.75% when compared to a regular PID controller.
Finally, it was proved that feedstock quality parameters affect the dynamic behaviour of gasification and including this information in model-based PID controllers improves their performance.
Quantum neural networks to simulate many-body quantum systems
Creators: name: Gardas, Bartłomiej
name: Rams, Marek M.
name: Dziarmaga, Jacek
Publisher: name: arXiv
Year: 2018
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We conduct experimental simulations of many body quantum systems using a \emph{hybrid} classical-quantum algorithm. In our setup, the wave function of the transverse field quantum Ising model is represented by a restricted Boltzmann machine. This neural network is then trained using variational Monte Carlo assisted by a D-Wave quantum sampler to find the ground state energy. Our results clearly demonstrate that already the first generation of quantum computers can be harnessed to tackle non-trivial problems concerning physics of many body quantum systems.
description: 6 pages, 4 figures
Additional fileÂ 1: of The knowledge and perceptions of the first year medical students of an International University on family planning and emergency contraception in Nicosia (TRNC)
Creators: name: Ozen Asut
name: Ovgu Ozenli
name: Gur, Gizem
name: Deliceo, Elif
name: Cagin, Buse
name: Korun, Okan
name: Ozgur Turk
name: Songul Vaizoglu
name: Cali, Sanda
Publisher: name: figshare
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Plant Biology

description: English questionnaire. (DOCX 17 kb)
Photometric Properties of Kiso Ultraviolet-Excess Galaxies in the Lynx-Ursa Major Region
Creators: name: Takeuchi, Tsutomu T.
name: Tomita, Akihiko
name: Nakanishi, Kouichiro
name: Ishii, Takako T.
name: Iwata, Ikuru
name: Saitō, Mamoru
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We have performed a systematic study of several regions in the sky where the number of galaxies exhibiting star formation (SF) activity is greater than average. We used Kiso ultraviolet-excess galaxies (KUGs) as our SF-enhanced sample. By statistically comparing the KUG and non-KUG distributions, we discovered four KUG-rich regions with a size of $\sim 10^\circ \times 10^\circ$. One of these regions corresponds spatially to a filament of length $\sim 60 h^{-1}$ Mpc in the Lynx-Ursa Major region ($α\sim 9^{\rm h} - 10^{\rm h}, δ\sim 42^\circ - 48^\circ$). We call this ``the Lynx-Ursa Major (LUM) filament''. We obtained $V(RI)_{\rm C}$ surface photometry of 11 of the KUGs in the LUM filament and used these to investigate the integrated colors, distribution of SF regions, morphologies, and local environments. We found that these KUGs consist of distorted spiral galaxies and compact galaxies with blue colors. Their star formation occurs in the entire disk, and is not confined to just the central regions. The colors of the SF regions imply that active star formation in the spiral galaxies occurred $10^{7 - 8}$ yr ago, while that of the compact objects occurred $10^{6-7}$ yr ago. Though the photometric characteristics of these KUGs are similar to those of interacting galaxies or mergers, most of these KUGs do not show direct evidence of merger processes.
description: 39 pages LaTeX, using aasms4.sty, 20 figures, ApJS accepted. The Title of the previous one was truncated by the author's mistake, and is corrected. Main body of the paper is unchanged
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VIII, Cart. 192 (11 H 77), 295 folios, f. 0143r
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VIII, Archives départementales de la Côte-d'Or, Cart. 192 (11 H 77), 295 folios, f. 0143r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VIII, Archives départementales de la Côte-d'Or, Cart. 192 (11 H 77), 295 folios, f. 0143r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876