cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Assessing the economics of biologic and small molecule therapies for the treatment of moderate to severe ulcerative colitis in Japan: a cost per responder analysis of upadacitinib
Creators: name: Saruta, Masayuki
name: Kawaguchi, Isao
name: Ogawa, Yuji
name: Gonzalez, Yuri Sanchez
name: Numajiri, Naoki
name: Tang, Xiaohe
name: Miller, Russell
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Patients with moderately to severely active ulcerative colitis have an increasing number of advanced therapy options including several biologics and Janus kinase inhibitors. Though data on efficacy and safety of these advanced therapies are available, less is known about the potential economic implications of their utilization in Japan. We evaluated the relative value of these advanced therapies in Japan using a locally developed cost per responder model. A model was developed using relevant clinical endpoints and treatment costs to calculate cost per responder of all advanced therapies used for moderately to severely active ulcerative colitis treatment in Japan. Cost per responder was assessed in biologic-naïve and biologic-exposed populations, respectively. The model incorporated induction and maintenance therapy pathways as patients progressed through based on efficacy rates (clinical response, clinical remission and endoscopic improvement). Total costs for induction and maintenance included: drug acquisition, drug administration and serious adverse event management (as necessary) for responders, with additional rescue treatment cost only for non-responders. Upadacitinib showed lower cost per clinical response and cost per clinical remission across both biologic-naïve and biologic-exposed populations with only one exemption in cost per clinical remission in biologic-naïve population. In addition, upadacitinib demonstrated lower cost per endoscopic improvement in both populations. Janus kinase inhibitors outperformed with lower cost per responder than other mediations across all outcomes and patient populations with the exception of tofacitinib for clinical remission in biologic-exposed UC population. Comparative data used in this analysis have been derived from network meta-analysis, not from direct comparison. The results of this cost per responder analysis suggest upadacitinib is a cost-effective option for the first- and second-line treatment of moderately to severely active ulcerative colitis in Japan.
The potential clinical impact and cost-effectiveness of the updated COVID-19 mRNA autumn 2024 vaccines in the United Kingdom
Creators: name: Kohli, Michele A.
name: Maschio, Michael
name: Lee, Amy
name: Joshi, Keya
name: Carroll, Stuart
name: Balogh, Orsolya
name: van de Velde, Nicholas
name: Beck, Ekkehard
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: To estimate the potential clinical impact and cost-effectiveness of a United Kingdom (UK) Autumn 2024 vaccination campaign with an updated Moderna COVID-19 vaccine in adults ≥65 years and eligible persons 6 months to 64 years of age over a 1-year time horizon (September 2024-August 2025). A compartmental Susceptible-Exposed-Infected-Recovered model was adapted to reflect COVID-19 cases in the UK. Numbers of symptomatic infections, COVID-19–related hospitalizations and deaths, costs, and quality-adjusted life-years (QALYs) were predicted using a decision tree. The incremental cost-effectiveness ratio (ICER) of an updated Moderna mRNA vaccine (Moderna Autumn 2024 Campaign) was compared to no Autumn 2024 vaccine and to an updated Pfizer-BioNTech mRNA Autumn 2024 vaccine, from a healthcare perspective. The Moderna Autumn 2024 Vaccination Campaign is predicted to decrease the expected 8.3 million symptomatic infections with no vaccination by 19% to 6.7 million. Hospitalizations, long COVID cases, and deaths are expected to decline by 27,000 (-38%), 59,000 (-19%), and 6000 (-43%), respectively. The Moderna Autumn 2024 Campaign will increase QALYs by 78,000 and costs by £665 million, yielding an ICER of £8500/QALY gained. Sensitivity analyses suggest that vaccine effectiveness (VE) and waning, symptomatic infection incidence, hospitalization rates, and mortality rates drive cost-effectiveness. Vaccination remains cost-effective when lowering the target population to ≥50 years. Use of the Moderna vaccine is expected to prevent 8000 more hospitalizations and 1700 more deaths than the updated Pfizer-BioNTech vaccine. Vaccination of the eligible population would contribute to significant reductions in hospitalizations, deaths, and long COVID in the UK in the 2024-2025 season. Expanding the target population continues to be cost-effective. Use of the Moderna Autumn 2024 Campaign is predicted to reduce SARS-CoV-2 infections and associated outcomes in a cost-effective manner and will contribute to a more resilient healthcare system in the UK.
Dactylorhiza lapponica Soo
Creators: name: Konrad Lauber
name: Gerhart Wagner
name: Andreas Gygax
Publisher: name: Haupt Verlag
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Dactylorhiza
Dactylorhiza lapponica

description: Dactylorhiza lapponica (Hartm.) Soó
Artbeschreibung: Ähnlich wie D. majalis, aber nur 10-30 cm hoch, Blütenstand locker und nur mit 5-15 Blüten, Blätter nur 2-5 (meist 3), abstehend, Lippe 3lappig bis herzförmig (bei D. majalis meist mit längerem Mittellappen), Sporn kegelförmig, waagrecht oder leicht abwärts gebogen (bei D. majalis relativ dick, zylindrisch bis kegelförmig, schwach abwärts gebogen). Die Art steht zwischen D. majalis und D. traunsteineri (Nr. 2560).
Blütezeit: 6-8
Standort und Verbreitung in der Schweiz: Flach- und Hangmoore, lehmige Rutschhänge / montan-subalpin / A, vereinzelt J und M
Verbreitung global: Mittel- und nordeuropäisch
Ökologische Zeigerwerte nach Landolt & al. (2010)
BodenfaktorenKlimafaktorenSalztoleranzFeuchtezahl F--Lichtzahl L--Salzzeichen--Reaktionszahl R--Temperaturzahl T--Nährstoffzahl N--Kontinentalitätszahl K--
Volksname Deutscher Name: Lappländische Fingerwurz Nom français: Orchis de Laponie Nome italiano: Orchide della Lapponia
description: Published as part of Konrad Lauber, Gerhart Wagner & Andreas Gygax, 2018, Flora Helvetica - Orchidaceae, pp. 1324-1362 in Flora Helvetica, Bern :Haupt Verlag on page 1342
Additional file 1: of Dynamic substrate preferences predict metabolic properties of a simple microbial consortium
Creators: name: Erbilgin, Onur
name: Bowen, Benjamin
name: Kosina, Suzanne
name: Jenkins, Stefan
name: Lau, Rebecca
name: Northen, Trent
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Supplemental Table 2 and Supplemental Figures 1-5. (PDF 781Â kb)
Additional file 1: of Dynamic substrate preferences predict metabolic properties of a simple microbial consortium
Creators: name: Erbilgin, Onur
name: Bowen, Benjamin
name: Kosina, Suzanne
name: Jenkins, Stefan
name: Lau, Rebecca
name: Northen, Trent
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Supplemental Table 2 and Supplemental Figures 1-5. (PDF 781Â kb)
Paronychodon lacustris Cope, 1876, gen. et sp. nov.
Creators: name: Cope, E. D.
Publisher: name: Zenodo
Year: 1876
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Dinosauria
Paronychodon
Paronychodon lacustris

description: Paronychodon lacustris, gen. et sp. nov.
Char. Gen. - The teeth which characterize this genus have the general character of those of Plesiosaurus, Elasmosaurus, etc. The crowns are subconic, and the enamel is thrown into longitudinial plicae. The special characters of the genus are seen in the form of the crown, one side of which is convex, and the other side plane, so that the section instead of being circular is seimicircular. It is also strongly curved in the direction of its plane face.
Char. Specif. - Both anterior and posterior edges are curved, and are not acute nor denticulate. There are four plicae on the flat face, only two of which approach the apex. There are six keels on the convex face, all of which approach the apex. All the carinae are rather obtuse, and the enamel is otherwise smooth. The apex is very acute.
Measurements.M.Length of tooth.0130Diameter at base antero-posterior.0040 transverse.0024.0040 transverse.0024Length of crown.0100
It is probable that portions of skeleton of this reptile are in my possession, but the means of positive identification are yet waniting.
description: Published as part of Cope, E. D., 1876, Descriptions of some vertebrate remains from the Fort Union beds of Montana, pp. 248-261 in Proceedings of the Academy of Natural Sciences of Philadelphia 28 on pages 256-257, DOI: 10.5281/zenodo.3371111
MOESM4 of Genome-wide association study for conformation traits in three Danish pig breeds
Creators: name: Le, Thu
name: Christensen, Ole
name: Nielsen, Bjarne
name: Goutam Sahana
Publisher: name: Figshare
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 4: Figure S4. Manhattan plot of within-breed multi-trait meta-analyses in (a) Landrace, (b) Yorkshire and (c) Duroc. The data provided represent the Manhattan plot of within-breed multi-trait meta-analyses in three breeds studied.
MOESM4 of Genome-wide association study for conformation traits in three Danish pig breeds
Creators: name: Le, Thu
name: Christensen, Ole
name: Nielsen, Bjarne
name: Goutam Sahana
Publisher: name: Figshare
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 4: Figure S4. Manhattan plot of within-breed multi-trait meta-analyses in (a) Landrace, (b) Yorkshire and (c) Duroc. The data provided represent the Manhattan plot of within-breed multi-trait meta-analyses in three breeds studied.
Cost effectiveness of pembrolizumab plus lenvatinib compared with chemotherapy for treating previously treated advanced endometrial cancer in Sweden
Creators: name: Ralph, Lewis
name: Young, Kate
name: Upadhyay, Navneet
name: Prabhu, Vimalanand Shrikant
name: Ljungcrantz, Christina
name: Massaad, Rachid
name: Xu, Ruifeng
name: Giertz, Anna
name: Merchant, Adil
name: Orlowski, Robert
name: Duska, Linda
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Pembrolizumab plus lenvatinib was recently approved for the treatment of advanced or recurrent endometrial carcinoma in women with disease progression on or following prior treatment with a platinum‑containing therapy in any setting, and who are not candidates for curative surgery or radiation (KEYNOTE-775/Study-309; NCT03517449). The objective was to assess the cost effectiveness of pembrolizumab plus lenvatinib compared with chemotherapy from a Swedish healthcare perspective. A lifetime partitioned-survival model with three health states (progression free, progressed disease, death) was constructed. Chemotherapy was represented by paclitaxel or doxorubicin. Overall survival, progression-free survival, time on treatment, and utility data were obtained from KEYNOTE-775 (database lock: March 1, 2022). Costs (in 2020 Swedish Krona [SEK]) included drug acquisition and administration, health state, end of life, adverse event management, subsequent treatment, and societal (scenario analysis). Outcomes were calculated as quality-adjusted life-years (QALY) and life-years. Model results were presented as incremental cost-effectiveness ratios for all-comers, patients with proficient mismatch repair tumors, and deficient mismatch repair tumors. Deterministic and probabilistic sensitivity analyses were conducted. Pembrolizumab plus lenvatinib is a cost-effective treatment when compared with chemotherapy, with estimated deterministic and probabilistic incremental cost-effectiveness ratios of SEK 795,712 and 819,757 per QALY gained. Pembrolizumab plus lenvatinib was associated with a large incremental QALY and life-year gain per person versus chemotherapy over the model time horizon (1.49 and 1.76). Time-to-event data were incomplete and semiparametric and parametric curves were utilized for lifetime extrapolation. Willingness-to-pay thresholds, costs, and utility weights vary by country, which would vary the treatment’s cost effectiveness in different countries. This partitioned survival analysis suggests that pembrolizumab plus lenvatinib is cost effective compared with chemotherapy in Sweden for women with advanced or recurrent endometrial carcinoma following previous systemic therapy. Results were robust to mismatch repair status and to changes in parameters/assumptions.
Additional file 1: of The economic burden of HIV/AIDS on individuals and households in Nepal: a quantitative study
Creators: name: Ak Poudel
name: Newlands, David
name: Padam Simkhada
Publisher: name: Figshare
Year: 2017
Subjects: subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Computational Biology

description: Survey Questionnaire. (PDF 350Â kb)
Dactylorhiza maculata Soo
Creators: name: Konrad Lauber
name: Gerhart Wagner
name: Andreas Gygax
Publisher: name: Haupt Verlag
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Dactylorhiza
Dactylorhiza maculata

description: Dactylorhiza maculata (L.) Soó
Artbeschreibung: 20-60 cm hoch. Stängel kaum hohl, unter dem Blütenstand ca. 2 mm dick, die obersten Blätter tragblattartig, den Blütenstand nicht erreichend, alle oberseits dunkelbraun gefleckt. Tragblätter meist grün, die Blüten nicht überragend. Blüten lila oder rosa bis weiss, mit dunkler Musterung. 3 Perigonblätter zusammenneigend, die 2 seitlichen äusseren abstehend. Sporn gerade, waagrecht oder abwärts gerichtet, meist etwas kürzer als der Fruchtknoten.
Ökologische Zeigerwerte nach Landolt & al. (2010)
BodenfaktorenKlimafaktorenSalztoleranzFeuchtezahl F--Lichtzahl L--Salzzeichen--Reaktionszahl R--Temperaturzahl T--Nährstoffzahl N--Kontinentalitätszahl K--
Volksname Deutscher Name: Gefleckte Fingerwurz Nom français: Orchis tacheté Nome italiano: Orchide macchiata
description: Published as part of Konrad Lauber, Gerhart Wagner & Andreas Gygax, 2018, Flora Helvetica - Orchidaceae, pp. 1324-1362 in Flora Helvetica, Bern :Haupt Verlag on page 1342
Clinical and economic benefits of patients undergoing lobectomy with the use of powered vascular staplers—based on China’s real-world data
Creators: name: Chen, Binbin
name: Fan, Changsheng
name: Tao, Libo
name: Cui, Bin
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Marine Biology
Cancer
Science Policy
Mental Health

description: Endoscopic surgery is widely performed with an increasing use of powered vascular staplers (PVS). However, few studies have examined PVS use in China, most of which have focused on clinical effects; fewer studies have examined the economic benefits of PVS. This study evaluated the clinical and economic benefits of the PVS compared to standard-of-care (SOC) staplers in lobectomy using results from a single-arm, multicenter clinical trial conducted in China and actual clinical use in a hospital collected in a real healthcare setting. Patients with lung cancer undergoing thoracoscopic lobectomy were included in the study. The clinical and economic benefits of powered vascular stapler have been evaluated from a hospital’s perspective based on parameters such as bleeding occurrence, hospitalization time, secondary thoracotomy, and hospitalization costs. To compare the bleeding associated with use of PVS and SOC stapler in clinical use, PVS single-arm multi-center clinical trial data is used for the intervention group, and sampling data from hospitals is used for the control group. To ensure the outcome indicators between the two groups are comparable, we set the same inclusion criteria for the two groups of data and then used propensity score matching (PSM) to match two groups of patients according to the baseline characteristics. The results show that bleeding incidence in patients with SOC stapler group is 17.33% from hospital sampling data. In contrast, in the PVS group, it is 4.00%, and these rates are statistically different (p = 0.0167). Considering converted to open thoracic surgery, the rate of the SOC stapler group is 5.78% and that of the PVS group is 4.00%. These rates are not statistically different (p = 0.6166). Regarding hospitalization days, the length of the SOC stapler group is 18.97 days, while that in the PVS group is 12.38 days, and these data are statistically different (p = 0.0002). As patients in the PVS group have reduced bleeding, they will require less resource use from blood transfusion, drug services, and surgical services. If PVS is used for transection of vessel, it can reduce the bleeding incidence by 13.33% and save 75.47 CNY in blood transfusion costs, 571.36 CNY in drug costs, and 183.38 CNY in surgical service costs per patient. From these three aspects, the hospital saves per patient 830.21 CNY. Compared with the SOC stapler group, the PVS group has a lower bleeding incidence and shorter hospital days for lobectomy. In terms of blood transfusion costs, drug costs, and surgical service costs, the hospital saves per patient 830.21 CNY.
Additional file 1: of Genetic relatedness analysis reveals the cotransmission of genetically related Plasmodium falciparum parasites in ThiĂ¨s, Senegal
Creators: name: Wong, Wesley
name: Griggs, Allison
name: Daniels, Rachel
name: Schaffner, Stephen
name: Ndiaye, Daouda
name: Bei, Amy
name: Deme, Awa
name: MacInnis, Bronwyn
name: Volkman, Sarah
name: Hartl, Daniel
name: Neafsey, Daniel
name: Dyann Wirth
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Figures S1â  S8 and Supplementary Table S1. (PDF 1415 kb)
Dactylorhiza maculata subsp. maculata
Creators: name: Konrad Lauber
name: Gerhart Wagner
name: Andreas Gygax
Publisher: name: Haupt Verlag
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Dactylorhiza
Dactylorhiza maculata
Dactylorhiza maculata (l.) soo subsp. maculata

description: Dactylorhiza maculata (L.) Soó subsp. maculata
Artbeschreibung: Blätter rinnig gefaltet, straff, das unterste lanzettlich, spitz. Obere Blätter schmal-lanzettlich, +/- steil aufwärts gerichtet. Lippe undeutlich 3lappig, Mittellappen klein, oft kürzer als die Seitenlappen.
Blütezeit: 7-8
Standort und Verbreitung in der Schweiz: Saure, nasse Böden, Moore / montan-subalpin / Sehr selten J, A (?)
Verbreitung global: Europäisch
Ökologische Zeigerwerte nach Landolt & al. (2010)
BodenfaktorenKlimafaktorenSalztoleranzFeuchtezahl Fsehr feucht; Feuchtigkeit stark wechselnd (mehr als ± 2 Stufen)Lichtzahl LhellSalzzeichen--Reaktionszahl Rstark sauer (pH 2.5-5.5)Temperaturzahl Tmontan (Wälder mit Buche, Weisstanne, in den Zentralalpen mit Waldföhre)Nährstoffzahl NnährstoffarmKontinentalitätszahl Ksubozeanisch (hohe Luftfeuchtigkeit, geringe Temperaturschwankungen, eher milde Winter)
Volksname Deutscher Name: Gewöhnliche Gefleckte Fingerwurz Nom français: Orchis tacheté
description: Published as part of Konrad Lauber, Gerhart Wagner & Andreas Gygax, 2018, Flora Helvetica - Orchidaceae, pp. 1324-1362 in Flora Helvetica, Bern :Haupt Verlag on page 1342
Additional file 3: of The role of total cell-free DNA in predicting outcomes among trauma patients in the intensive care unit: a systematic review
Creators: name: Gรถgenur, Mikail
name: Burcharth, Jakob
name: Gรถgenur, Ismail
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Risk of bias assessment. Results of risk of bias assessment for each study. (DOCX 18ย�kb)
Hedronchus sternbergii Cope, 1876, gen. et sp. nov.
Creators: name: Cope, E. D.
Publisher: name: Zenodo
Year: 1876
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Hedronchus
Hedronchus sternbergii

description: Hedronchus sternbergii, gen. et sp. nov.
Char.Gen.-The bone on which this genus reposes has the appearance of the crown of a young tooth. Its central cavity is large and expands to the margin of the basis; its apex is unworn. It appears to be too protuberant for the position of a dermal tubercle. It may be distinguished as a short crown on a shorter slightly constricted portion or neck. The crown culminates in three crests, which together form a letter T, and which descend towards the neck. There is no investment of enamel or cement, and the material of which it is composed resembles dense bone.
Char. Specif. - The faces on each side of the stem of the T, are conicave anid divided by an oblique crest, which descencls fromnthe common apex. The other face is gently convex, and the inferior part of each of its bounding crests projects ear-like. The base is an oval.
Measurements.M.Elevation of crown.006Diameter of base longitudinal.005 transverse.004.005 transverse.004
Discovered by Charles H. Sternberg.
description: Published as part of Cope, E. D., 1876, Descriptions of some vertebrate remains from the Fort Union beds of Montana, pp. 248-261 in Proceedings of the Academy of Natural Sciences of Philadelphia 28 on page 259, DOI: 10.5281/zenodo.3371111
Additional file 2: of Ecological validity of cost-effectiveness models of universal HPV vaccination: a protocol for a systematic review
Creators: name: Favato, Giampiero
name: Noikokyris, Emmanouil
name: Vecchiato, Riccardo
Publisher: name: Figshare
Year: 2017
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Search strategies. The data provided shows the comprehensive search strategy for the main bibliographic databases. (DOCX 15Â kb)
Public health and economic impact of COVID-19 vaccination with the Pfizer-BioNTech COVID-19 Vaccine, KP.2, among adults in 2024/2025 in the United States
Creators: name: Yehoshua, Alon
name: Di Fusco, Manuela
name: Rudolph, Abby E.
name: Thoburn, Elizabeth
name: Lopez, Santiago M.C.
name: Marczell, Kinga
name: Yarnoff, Benjamin
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: To assess the public health and economic impact of vaccination with the Pfizer-BioNTech COVID-19 vaccine, KP.2, in 2024/2025 in the United States. A combined cohort Markov-decision tree model was used to estimate the cost-effectiveness and budget impact of vaccination versus no vaccination in adults aged ≥18 years. The adult population was further stratified into 18-64 years and ≥65 years age groups. Public health surveillance data informed the annual proportion of individuals infected with and vaccinated against SARS-CoV-2 and the proportion of those infected who were hospitalized, stratified by age. Other age-stratified clinical, cost, and vaccine effectiveness parameters were informed by literature. The budget impact analysis was based on a hypothetical 1-million-member plan and used a payer perspective. Parameter uncertainty was tested in sensitivity analyses. Without vaccination, the model projected 21.4 million new symptomatic cases, 15,793 deaths, 629,098 hospitalizations, $115.5 billion in total costs, and 1 million QALYs lost among adults aged ≥18 years, with the greatest health burden observed among older adults aged ≥65 years (72% of hospitalizations and 86% of deaths) and the greatest economic burden in adults aged 18 to 64 years (62% of total costs). Vaccination was projected to prevent 915,501 cases, 1,057 deaths, and 37,489 hospitalizations, resulting in cost savings of $513 million, 9,173 LYs gained, 56,482 QALYs gained, and a dominant ICER. In the budget impact analysis, vaccination was estimated to result in total incremental cost savings for the population aged ≥ 65 years and a modest budget increase for the population aged 18 to 64 years. Vaccination with the Pfizer BioNTech COVID-19 vaccine, KP.2, is a cost-effective measure from the societal perspective at a willingness-to-pay threshold of $50,000 that could reduce the health and economic burden of COVID-19.
Myledaphus bipartitus Cope, 1876, gen. et sp.nov.
Creators: name: Cope, E. D.
Publisher: name: Zenodo
Year: 1876
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Chondrichthyes
Lamniformes
Anacoracidae
Myledaphus
Myledaphus bipartitus

description: Myledaphus bipartitus, gen. et sp.nov.
Char. Gen. - Crowns of the teeth molar in character, truncate, wider than long, standing table-like on the root. The latter partakinig of the shape of the crown, short, straight, split equally and at right angles to the greatest diameter of the tooth. The crowns form a pavement having a regularly hexagonal outline. Their composition is different in the halves on each side of a line which divides the crown equally, running in the long direction. On one side the dentine is striate at right angles to the long diameter; the structure is not distinguishable by the hand lens on the opposite side of the line.
The affinities of this genus cannot now be stated, but the form of the root recalls the Elosmobranchii,
and that of the crown, some of the rays.
Char. Specif. -The staining on opposite sides of the line that divides the crown, is different, on the one paler than on the other. The face of the crown is nearly plane, and its border is vertical and overhangs the root all round in a narrow ledge; it is vertically striate, as is also the root. The antero-posterior diameter exceeds the transverse, and the facets are subequal, and are continued less perfectly on the root. The fissure of the latter does not reach the base of the crown.
Measurements.M.Length of tooth.0053Diameter of crown antero-posterior.0060 transverse.0045.0060 transverse.0045Long diameter of root.0050Length of root.0030
Discovered by Charles H. Steinberg.
description: Published as part of Cope, E. D., 1876, Descriptions of some vertebrate remains from the Fort Union beds of Montana, pp. 248-261 in Proceedings of the Academy of Natural Sciences of Philadelphia 28 on pages 260-261, DOI: 10.5281/zenodo.3371111
THE QUESTION OF DIRECTING STUDENTS TO PROFESSIONAL EDUCATION
Creators: name: Normurodov, Sanjar
Publisher: name: Zenodo
Year: 2024

description: In various interpretations, both scientific and reference literature, the field of education is understood as a complex of structural features that reflect the peculiarities, laws of the cultural space of an educational institution and a particular society. In addition to this concept, state documents on education, modern pedagogical research and scientific work use the concept of “field of Education”, which means “the unity of educational, extracurricular and socially significant activities of students. Creating such an environment requires the teacher to constantly creatively search for new effective forms and technologies, organizational foundations and innovative tools” [4].
Dactylorhiza maculata subsp. fuchsii Hyl.
Creators: name: Konrad Lauber
name: Gerhart Wagner
name: Andreas Gygax
Publisher: name: Haupt Verlag
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Dactylorhiza
Dactylorhiza maculata
Dactylorhiza maculata subsp. fuchsii (druce) hyl.

description: Dactylorhiza maculata subsp. fuchsii (Druce) Hyl.
Artbeschreibung: Blätter 5-10, +/- flach, die unteren abstehend oder dem Boden aufliegend, das unterste kurz und zungenförmig. Lippe tief 3spaltig, Mittellappen gross, die Seitenlappen oft weit überragend. Sporn waagrecht oder abwärts gebogen.
Blütezeit: 5-8
Standort und Verbreitung in der Schweiz: Basische bis neutrale, feuchte Wiesen, Wälder / kollin-alpin / CH
Verbreitung global: Eurasiatisch
Ökologische Zeigerwerte nach Landolt & al. (2010)
BodenfaktorenKlimafaktorenSalztoleranzFeuchtezahl F--Lichtzahl L--Salzzeichen--Reaktionszahl R--Temperaturzahl T--Nährstoffzahl N--Kontinentalitätszahl K--
Volksname Deutscher Name: Fuchs' Gefleckte Fingerwurz Nom français: Orchis de Fuchs
description: Published as part of Konrad Lauber, Gerhart Wagner & Andreas Gygax, 2018, Flora Helvetica - Orchidaceae, pp. 1324-1362 in Flora Helvetica, Bern :Haupt Verlag on page 1342
Additional file 1: of Genetic relatedness analysis reveals the cotransmission of genetically related Plasmodium falciparum parasites in ThiĂ¨s, Senegal
Creators: name: Wong, Wesley
name: Griggs, Allison
name: Daniels, Rachel
name: Schaffner, Stephen
name: Ndiaye, Daouda
name: Bei, Amy
name: Deme, Awa
name: MacInnis, Bronwyn
name: Volkman, Sarah
name: Hartl, Daniel
name: Neafsey, Daniel
name: Dyann Wirth
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Figures S1â  S8 and Supplementary Table S1. (PDF 1415 kb)
MOESM3 of Genome-wide association study for conformation traits in three Danish pig breeds
Creators: name: Le, Thu
name: Christensen, Ole
name: Nielsen, Bjarne
name: Goutam Sahana
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 3: Figure S3. Manhattan plot of GWAS in Duroc pigs for (a) FRONT, (b) BACK, (c) HIND and (d) CONF. The data provided represent the Manhattan plot of single-trait association analyses in Duroc pigs for four traits studied.
Additional file 1: of GSAR: Bioconductor package for Gene Set analysis in R
Creators: name: Rahmatallah, Yasir
name: Zybailov, Boris
name: Emmert-Streib, Frank
name: Glazko, Galina
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Computational Biology

description: Additional document presenting computational considerations and uniqueness of package GSAR. (DOCX 32 kb)
MOESM3 of Genome-wide association study for conformation traits in three Danish pig breeds
Creators: name: Le, Thu
name: Christensen, Ole
name: Nielsen, Bjarne
name: Goutam Sahana
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 3: Figure S3. Manhattan plot of GWAS in Duroc pigs for (a) FRONT, (b) BACK, (c) HIND and (d) CONF. The data provided represent the Manhattan plot of single-trait association analyses in Duroc pigs for four traits studied.
Additional file 1: Table S1. of Humans from Wuchereria bancrofti endemic area elicit substantial immune response to proteins of the filarial parasite Brugia malayi and its endosymbiont Wolbachia
Creators: name: Jha, Ruchi
name: Gangwar, Mamta
name: Dhanvantri Chahar
name: Balakrishnan, Anand Setty
name: Negi, Mahendra
name: Shailja Misra-Bhattacharya
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Computational Biology

description: Detailed information of the individuals of bancroftian filariasis endemic area participated in the current study. (PDF 54 kb)
Additional file 2: of Ecological validity of cost-effectiveness models of universal HPV vaccination: a protocol for a systematic review
Creators: name: Favato, Giampiero
name: Noikokyris, Emmanouil
name: Vecchiato, Riccardo
Publisher: name: Figshare
Year: 2017
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Search strategies. The data provided shows the comprehensive search strategy for the main bibliographic databases. (DOCX 15Â kb)
Additional file 1: of The role of total cell-free DNA in predicting outcomes among trauma patients in the intensive care unit: a systematic review
Creators: name: Gรถgenur, Mikail
name: Burcharth, Jakob
name: Gรถgenur, Ismail
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: cfDNA measurement. CfDNA assessment checkpoints. (DOCX 14ย�kb)
Additional file 1: of Ecological validity of cost-effectiveness models of universal HPV vaccination: a protocol for a systematic review
Creators: name: Favato, Giampiero
name: Noikokyris, Emmanouil
name: Vecchiato, Riccardo
Publisher: name: Figshare
Year: 2017
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: PRISMA-P 2015 checklist. List of recommended items to address in a systematic review protocol. (DOC 82Â kb)
Savings associated with surgical aortic valve replacement with a RESILIA tissue valve based on seven-year COMMENCE trial results
Creators: name: Keuffel, Eric L.
name: Reifenberger, Matt
name: Pellegrini, Andrew
name: Nguyen, Tom C.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Science Policy

description: Bioprostheses with RESILIA tissue demonstrate a reduction in calcification and improve health outcomes in pre-clinical and clinical studies. Prior economic analyses which relied on 5 years of evidence from the COMMENCE trial demonstrate financial savings for RESILIA tissue valves relative to mechanical valves after surgical aortic valve replacement (SAVR). Given the recent release of 7-year COMMENCE data, this economic evaluation updates the estimate for long-run savings of bioprosthetic valves with RESILIA. Simulation models estimated disease progression across two hypothetical SAVR cohorts (tissue vs. mechanical) of 10,000 patients each in the US. The primary comparison calculated the SAVR-related expenditures associated with each valve type ($US, 2023). Health outcome probabilities were based on the COMMENCE trial though year 7 and projected for an additional 8 years based on prior studies of tissue and mechanical SAVR. Costs for key outcomes (mortality, reoperation, bleeding, thromboembolism, endocarditis) and anticoagulant monitoring were sourced from the literature. Incidence rates of health outcomes associated with mechanical valves relied on relative risks of tissue valve versus mechanical valve patients. Seven-year savings are $13,415 (95% CI = $10,472–$17,321) per patient when comparing RESILIA versus mechanical SAVR. Projected 15-year savings were $23,001 ($US, 2023; 95% CI = $17,802–$30,421). Most of the 15-year savings are primarily attributed to lower anti-coagulation monitoring costs ($21,073 in ACM savings over 15 years), but lower bleeding cost (savings: $2,294) and thromboembolism-related expenditures (savings: $852) also contribute. Reoperation and endocarditis expenditures were slightly larger in the RESILIA cohort. If reoperation relative risk reverts from 1.1 to 2.2 (the level in legacy tissue valves) after year 7, savings are $18,064. RESILIA SAVR also reduce costs relative to legacy tissue valves. Patients receiving RESILIA tissue valves are projected to have lower SAVR-related health expenditures relative to mechanical and legacy tissue valves.
MOESM2 of Genome-wide association study for conformation traits in three Danish pig breeds
Creators: name: Le, Thu
name: Christensen, Ole
name: Nielsen, Bjarne
name: Goutam Sahana
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 2: Figure S2. Manhattan plot of GWAS in Yorkshire pigs for (a) FRONT, (b) BACK, (c) HIND and (d) CONF. The data provided represent the Manhattan plot of single-trait association analyses in Yorkshire pigs for four traits studied.
Dactylorhiza maculata subsp. savogiensis Kreutz
Creators: name: Konrad Lauber
name: Gerhart Wagner
name: Andreas Gygax
Publisher: name: Haupt Verlag
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Liliopsida
Asparagales
Orchidaceae
Dactylorhiza
Dactylorhiza maculata
Dactylorhiza maculata subsp. savogiensis (d. tyteca & gathoye) kreutz

description: Dactylorhiza maculata subsp. savogiensis (D. Tyteca & Gathoye) Kreutz
Artbeschreibung: Ähnlich wie D. fuchsii, aber nur mit 3-6 Laubblättern. Mittellappen der Lippe nur wenig verlängert, Seitenlappen abgerundet, oft vorne umgeschlagen und seitlich hochgezogen. Blüten dunkler. Sporn meist abwärts gerichtet.
Blütezeit: 6-7
Standort und Verbreitung in der Schweiz: Feuchte Wiesen, Flachmoore, auf Silikat / montan-alpin / A (Verbreitung noch ungenügend bekannt)
Verbreitung global: Alpin
Ökologische Zeigerwerte nach Landolt & al. (2010)
BodenfaktorenKlimafaktorenSalztoleranzFeuchtezahl Fsehr feucht; Feuchtigkeit stark wechselnd (mehr als ± 2 Stufen)Lichtzahl LhellSalzzeichen--Reaktionszahl Rsauer (pH 3.5-6.5)Temperaturzahl Tsubalpin (Fichtenwälder ohne Buchen bis zur Obergrenze der Fichte)Nährstoffzahl NnährstoffarmKontinentalitätszahl Ksubozeanisch bis subkontinental (mittlere Luftfeuchtigkeit, mässige Temperaturschwankungen und mässig tiefe Wintertemperaturen)
Volksname Deutscher Name: Savoyer Fingerwurz Nom français: Orchis de Savoie, Orchidée de Savoie Nome italiano: Orchide della Savoia
description: Published as part of Konrad Lauber, Gerhart Wagner & Andreas Gygax, 2018, Flora Helvetica - Orchidaceae, pp. 1324-1362 in Flora Helvetica, Bern :Haupt Verlag on page 1342
MOESM2 of Genome-wide association study for conformation traits in three Danish pig breeds
Creators: name: Le, Thu
name: Christensen, Ole
name: Nielsen, Bjarne
name: Goutam Sahana
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 2: Figure S2. Manhattan plot of GWAS in Yorkshire pigs for (a) FRONT, (b) BACK, (c) HIND and (d) CONF. The data provided represent the Manhattan plot of single-trait association analyses in Yorkshire pigs for four traits studied.
A Multilevel Strategy to Improve People Tracking in a Real-World Scenario
Creators: name: de Oliveira, Cristiano B.
name: Neves, Joao C.
name: Ribeiro, Rafael O.
name: Menotti, David
Publisher: name: arXiv
Year: 2024
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: The Palácio do Planalto, office of the President of Brazil, was invaded by protesters on January 8, 2023. Surveillance videos taken from inside the building were subsequently released by the Brazilian Supreme Court for public scrutiny. We used segments of such footage to create the UFPR-Planalto801 dataset for people tracking and re-identification in a real-world scenario. This dataset consists of more than 500,000 images. This paper presents a tracking approach targeting this dataset. The method proposed in this paper relies on the use of known state-of-the-art trackers combined in a multilevel hierarchy to correct the ID association over the trajectories. We evaluated our method using IDF1, MOTA, MOTP and HOTA metrics. The results show improvements for every tracker used in the experiments, with IDF1 score increasing by a margin up to 9.5%.
description: Accepted for presentation at the International Conference on Computer Vision Theory and Applications (VISAPP) 2024
Clinical and economic benefits of patients undergoing lobectomy with the use of powered vascular staplers—based on China’s real-world data
Creators: name: Chen, Binbin
name: Fan, Changsheng
name: Tao, Libo
name: Cui, Bin
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Marine Biology
Cancer
Science Policy
Mental Health

description: Endoscopic surgery is widely performed with an increasing use of powered vascular staplers (PVS). However, few studies have examined PVS use in China, most of which have focused on clinical effects; fewer studies have examined the economic benefits of PVS. This study evaluated the clinical and economic benefits of the PVS compared to standard-of-care (SOC) staplers in lobectomy using results from a single-arm, multicenter clinical trial conducted in China and actual clinical use in a hospital collected in a real healthcare setting. Patients with lung cancer undergoing thoracoscopic lobectomy were included in the study. The clinical and economic benefits of powered vascular stapler have been evaluated from a hospital’s perspective based on parameters such as bleeding occurrence, hospitalization time, secondary thoracotomy, and hospitalization costs. To compare the bleeding associated with use of PVS and SOC stapler in clinical use, PVS single-arm multi-center clinical trial data is used for the intervention group, and sampling data from hospitals is used for the control group. To ensure the outcome indicators between the two groups are comparable, we set the same inclusion criteria for the two groups of data and then used propensity score matching (PSM) to match two groups of patients according to the baseline characteristics. The results show that bleeding incidence in patients with SOC stapler group is 17.33% from hospital sampling data. In contrast, in the PVS group, it is 4.00%, and these rates are statistically different (P = 0.0167). Considering converted to open thoracic surgery, the rate of the SOC stapler group is 5.78% and that of the PVS group is 4.00%. These rates are not statistically different (P = 0.6166). Regarding hospitalization days, the length of the SOC stapler group is 18.97 days, while that in the PVS group is 12.38 days, and these data are statistically different (P = 0.0002). As patients in the PVS group have reduced bleeding, they will require less resource use from blood transfusion, drug services and surgical services. If PVS is used for transection of vessel, it can reduce the bleeding incidence by 13.33% and save 75.47 CNY in blood transfusion costs, 571.36 CNY in drug costs, and 183.38 CNY in surgical service costs per patient. From these three aspects, the hospital saves per patient 830.21 CNY. Compared with the SOC stapler group, the PVS group has a lower bleeding incidence and shorter hospital days for lobectomy. In terms of blood transfusion costs, drug costs and surgical service costs, the hospital saves per patient 830.21 CNY.