cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The cGAS-STING Defense Pathway and Its Counteraction by Viruses
Creators: name: Ma, Zhe
name: Damania, Blossom
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Upon viral infection, host cells mount a concerted innate immune response involving type I interferon and pro-inflammatory cytokines to enable elimination of the pathogen. Recently cGAS and STING have been identified as intracellular sensors that activate the interferon pathway in response to virus infection and thus mediate host defense against a range of DNA and RNA viruses. Here we review how viruses are sensed by the cGAS-STING signaling pathway as well as how viruses modulate this pathway. Mechanisms utilized by viral proteins to inhibit cGAS and/or STING are also discussed. On the flip side, host cells have also evolved strategies to thwart viral immune escape. The balance between host immune control and viral immune evasion is pivotal to viral pathogenesis and we discuss this virus-host stand-off in the context of the cGAS-STING innate immune pathway.
Topographical analysis in autism and dyslexia
Creators: name: Esenther, Anna
name: Manning, Catherine
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medical Sciences
subject: Neurosciences
subject: FOS: Clinical medicine
subject: Medicine and Health Sciences

description: A TANOVA analysis to investigate whether autistic, dyslexic, and typically developing children show differences in topography in their evoked responses to visual motion
title: Krypton enhanced ventilation imaging with single-source dual energy CT: preliminary feasibility study in a population of lung transplant recipients
Creators: name: Ohana, Mickaël
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Thorax
subject: Contrast agents
subject: Respiratory system
subject: CT
subject: Image manipulation / Reconstruction
subject: Contrast agent-other
subject: Safety
subject: Technology assessment
subject: Grafts
subject: Image registration

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Accurate and reproducible routine quantification of ventilation is currentlythe exclusive domain of pulmonary function tests , which offeraclearcharacterization of airway obstruction, pulmonary distension and restriction, at a moderate cost. Their...
An Eye-region specific Dual-dimension Covariation Enhancement Effect in Facial Information Change Detection
Creators: name: Sun, Yu-Hao
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Experimental Analysis of Behavior
subject: Cognition and Perception
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: Multidimensional facial information integration has not been observed on facial-region level in previous face perception studies. In this current paper, we explored whether configural and featural information integrate on facial-region level and how such dual-dimension integration interact in and modulated by face holistic processing.
การศึกษาเปรียบเทียบการระบายอากาศของห้องพักอาศัยคอนโดมิเนียมโดยวิธีการสลายของแก๊ส และการอัดอากาศ
Creators: name: พิมพ์พรรณ จิโรจน์วงศ์
Publisher: name: Thammasat Printing House
Year: 2018
Subjects: การระบายอากาศ
ความเข้มข้นของคาร์บอนไดออกไซด์
การทดสอบประสิทธิภาพในอาคารจริง
การอัดอากาศ

description: Journal of Architectural/Planning Research and Studies, 15, 1, 127-134
New Zealand maternity and midwifery services responses to Covid-19
Creators: name: Zhao, Yan
name: Maude, Robyn
name: Bradford, Billie
name: Crowther, Susan
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences

description: To examine and map the national and international guidance and information provided to midwifery and maternity health care providers regarding covid-19 pandemic.
Pseudomonas syringae  Type III Effector HopBB1 Promotes Host Transcriptional Repressor Degradation to Regulate Phytohormone Responses and Virulence
Creators: name: English, Marie E.
name: Mieczkowski, Piotr
name: Epple, Petra
name: He, Yijian
name: Yang, Li
name: Dangl, Jeffery L.
name: Biswas, Surojit
name: Teixeira, Paulo José Pereira Lima
name: Finkel, Omri M.
name: Salas-Gonzalez, Isai
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Independently evolved pathogen effectors from three branches of life (ascomycete, eubacteria, and oomycete) converge onto the Arabidopsis TCP14 transcription factor to manipulate host defense. However, the mechanistic basis for defense control via TCP14 regulation is unknown. We demonstrate that TCP14 regulates the plant immune system by transcriptionally repressing a subset of the jasmonic acid (JA) hormone signaling outputs. A previously unstudied Pseudomonas syringae (Psy) type III effector, HopBB1, interacts with TCP14 and targets it to the SCFCOI1 degradation complex by connecting it to the JA signaling repressor JAZ3. Consequently, HopBB1 de-represses the TCP14-regulated subset of JA response genes and promotes pathogen virulence. Thus, HopBB1 fine-tunes host phytohormone crosstalk by precisely manipulating part of the JA regulon to avoid pleiotropic host responses while promoting pathogen proliferation.
title: Squamous cell carcinoma and adenocarcinoma show different perfusion in DCE-CT studies of lung cancer
Creators: name: Baiocco, Serena
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Oncology
subject: Lung
subject: Computer applications
subject: CT-Quantitative
subject: Decision analysis
subject: Imaging sequences
subject: Cancer
subject: Multidisciplinary cancer care

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Non-small-cell lung cancer (NSCLC) accounts for 80–85% of lung cancers andis the most common cause of cancer mortality worldwide for both men and women [1].Histologically, NSCLC is divided into adenocarcinoma (AC), squamous cell carcinoma...
title: Single centre experience with percutaneous radiofrequency ablation for autonomously functioning thyroid nodules
Creators: name: Mavrovi, Erti
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Thyroid / Parathyroids
subject: Interventional non-vascular
subject: Ultrasound
subject: Percutaneous
subject: Nuclear medicine conventional
subject: Ablation procedures
subject: Metabolic disorders

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Approximately 10% of solitary nodulesarescintigraphically hot, half of which are autonomously functioning. Subclinical hyperthyroidism is present in 75% of patientswith an autonomously functioning thyroid nodules (AFTN),with approximately 4% per...
title: Synthese carbo- und heterocyclischer π-Elektronensysteme mit pentafulvenoiden Chlorformamidinium-chloriden
Creators: name: Hafner, Klaus
name: Krimmer, Hans-Peter
Publisher: name: Wiley
Year: 2023

description: Neue Schlüsselverbindungen für einfache Synthesen ungesättigter Carbo- und Heterocyclen sind die Chlorformamidinium-chloride (2). Beispielsweise reagiert (2), R = X = H, n =; 1, mit NH3 zu (3)
title: Benefits of the MRI in functional weight bearing, in presence of peroneal instability in athletes
Creators: name: Giannini, Silvana
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Musculoskeletal joint
subject: MR
subject: Imaging sequences
subject: Education and training

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: We have used a dynamic MRI in weight bearing to show and confirm the total and partial tear of the peroneal retinaculum and tendinous...
Pattern formation in binary fluid mixtures induced by short-range competing interactions
Creators: name: Bores, C.
name: Lomba, E.
name: Perera, A.
name: Almarza, N. G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Molecular dynamics simulations and integral equation calculations of a simple equimolar mixture of diatomic molecules and monomers interacting via attractive and repulsive short-range potentials show the existence of pattern formation (microheterogeneity), mostly due to depletion forces away from the demixing region. Effective site-site potentials extracted from the pair correlation functions using an inverse Monte Carlo approach and an integral equation inversion procedure exhibit the features characteristic of a short-range attractive and long-range repulsive potential. When charges are incorporated into the model, this becomes a coarse grained representation of a room temperature ionic liquid, and as expected, intermediate range order becomes more pronounced and stable.
title: Diffusion weighted imaging versus subtraction MRI in assessing treatment response of hepatocellular carcinoma after trans-arterial chemoembolisation (TACE)
Creators: name: Essam, Muhammad
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Abdomen
subject: Abdomen
subject: Gastrointestinal tract
subject: MR-Diffusion/Perfusion
subject: MR
subject: MR-Angiography
subject: Contrast agent-intravenous
subject: Neoplasia

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The aim of this study is to evaluate the efficiency of both diffusion weighted images and subtracted dynamic MRI technique in the detection of residual/ recurrent disease after (TACE) ablation of non resectable HCC lesions. Accurate judgment of...
Ruderman-Kittel-Kasuya-Yosida interaction in Weyl semimetals
Creators: name: Hosseini, Mir Vahid
name: Askari, Mehdi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We theoretically demonstrate the Ruderman-Kittel-Kasuya-Yosida interaction between magnetic impurities that is mediated by the Weyl fermions embedded inside a three-dimensional Weyl semimetal (WSM). The WSM is characterized by a pair of Weyl points separated in the momentum space. Using the Green's function method and a two-band model, we show that four terms contribute to the magnetic impurity interaction in the WSM phase: the Heisenberg, Dzyaloshinsky-Moriya, spin-frustrated and Ising terms. Except the last term which is vanishingly small in the plane perpendicular to the line connecting two Weyl points, all the other interaction terms are finite. Furthermore, the magnetic spins of the Dzyaloshinsky-Moriya and spin-frustrated terms lie in the plane perpendicular to the line connecting two Weyl points, but in this plane, the magnetic spins of the Ising term have no components. For each contribution, an analytical expression is obtained, falling off with a spatial dependence as $R^{-5}$ at Weyl points and showing beating behavior that depends on the direction between two magnetic impurities.
description: 6 pages, 4 figures
Creating a connected campus: the importance of planning for universities
Creators: name: Malbon, Lindsay
name: Dixon, Aaron
name: Zicong, Niccolai
Publisher: name: Vancouver Island University - Royal Roads University
Year: 2018
Subjects: subject: City planning

description: When the words “urban planning” are mentioned, it is likely that municipal and land use planning comes to mind. Although diverse types of planning are often discussed, one area of planning that appears to be underutilized is planning for universities. The built environment of a university has the ability to shape the experience of staff, faculty, students, and visitors in many different ways. Having a successful campus plan can improve the quality of life and change the way people move around and spend time at a university.
description: https://viurrspace.ca/bitstream/handle/10613/8606/Malbon.pdf?sequence=3&isAllowed=y
Ubaldino Peruzzi a Luigi Calamai (6 luglio 1848)
Creators: name: Peruzzi, Ubaldino
name: Calamai, Luigi
Publisher: name: Zenodo
Year: 2023
Subjects: Accademia dei Georgofili
Peruzzi, Ubaldino
Calamai, Luigi
Lettera
Carteggio
Correspondence
Letter
1848

description: Lettera di Ubaldino Peruzzi a Luigi Calamai del 6 luglio 1848. Segnatura dell’unità documentale: Archivio storico dell’Accademia dei Georgofili, Carteggio, Busta 30, 2227. Natura: manoscritto. Consistenza: cc. 2
description: Digitalizzato come parte della Mostra virtuale: Ubaldino Peruzzi : un percorso in rete : in occasione del bicentenario della nascita. https://www.georgofili.it/contenuti/ubaldino-peruzzi-un-percorso-in-rete/17485
Emerging issues in cannabis: a look at home production for medicinal use in British Columbia
Creators: name: Bator, Cody
Publisher: name: Vancouver Island University - Royal Roads University
Year: 2018
Subjects: subject: City planning

description: As of October 17, 2018, the Government of Canada has legalized the sale and consumption of cannabis for recreational use. Although marijuana has only recently become legal for those of majority age, local governments have been dealing with issues surrounding grow operations for some time now. Personal use production licenses have opened the door for home-based marijuana production facilities, and at the end of the 2017/2018 fiscal year, over 3,800 of those licenses were active in British Columbia (Health Canada, 2018c). Lack of regulatory monitoring around licensed medicinal grow operations have prompted concerns of health and safety. With restricted access to information and limited resources, local governments struggle to enforce bylaws and building regulations that aim to protect residents from these potential risks.
description: https://viurrspace.ca/bitstream/handle/10613/8607/Bator.pdf?sequence=3&isAllowed=y
AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival
Creators: name: Richards, Kristy L.
name: Goraksha-Hicks, Pankuri
name: Macintyre, Andrew N.
name: Nichols, Amanda G.
name: Siska, Peter J.
name: Barnes, Carson E.
name: Gerriets, Valerie A.
name: Abel, E. Dale
name: Warmoes, Marc O.
name: De Cubas, Aguirre A.
name: Gershon, Timothy R.
name: Liu, Tingyu
name: Rathmell, Jeffrey C.
name: Yeoh, Allen Eng Juh
name: Locasale, Jason W.
name: Rathmell, W. Kimryn
name: Cohen, Sivan
name: Kishton, Rigel J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: T cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy associated with Notch pathway mutations. While both normal activated and leukemic T cells can utilize aerobic glycolysis to support proliferation, it is unclear to what extent these cell populations are metabolically similar and if differences reveal T-ALL vulnerabilities. Here we show that aerobic glycolysis is surprisingly less active in T-ALL cells than proliferating normal T cells and that T-ALL cells are metabolically distinct. Oncogenic Notch promoted glycolysis but also induced metabolic stress that activated 5' AMP-activated kinase (AMPK). Unlike stimulated T cells, AMPK actively restrained aerobic glycolysis in T-ALL cells through inhibition of mTORC1 while promoting oxidative metabolism and mitochondrial Complex I activity. Importantly, AMPK deficiency or inhibition of Complex I led to T-ALL cell death and reduced disease burden. Thus, AMPK simultaneously inhibits anabolic growth signaling and is essential to promote mitochondrial pathways that mitigate metabolic stress and apoptosis in T-ALL.
title: Real-time pressure indicator makes mammographic breast compression more reproducible than a rule of thumb
Creators: name: van Lier, Monique
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Breast
subject: Mammography
subject: Physics
subject: Technical aspects
subject: Equipment
subject: Quality assurance
subject: Education and training

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Breast compression during x-ray mammography improves image quality and decreases radiation dose. According to European guidelines, the breast compression during x-ray mammography should be firm but tolerable [1]. The current way of working results...
Starobinsky Model in Rainbow Gravity
Creators: name: Chatrabhuti, Auttakit
name: Yingcharoenrat, Vicharit
name: Channuie, Phongpichit
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: In this paper, we study the Starobinsky model of inflation in the context of gravity's rainbow theory. We propose that gravity rainbow functions can be written in the power-law form of the Hubble parameter. We present a detailed derivation of the spectral index of curvature perturbation and the tensor-to-scalar ratio and compare the predictions of our models with Planck 2015 data. We discover that in order to be consistent with Planck data up to $2σ$ C.L., the viable values of $N_{k}$ $e$-folds would satisfy $42\lesssim N_{k}\lesssim 87$ and the rainbow parameter $λ$ is nicely constrained to be $λ\lesssim6.0$.
description: 10 pages, 3 figures. v2: corrections and improvement, version to appear in PRD
Making space for bees, radical planning and the messy city
Creators: name: Delaney, Kirby
Publisher: name: Vancouver Island University - Royal Roads University
Year: 2018
Subjects: subject: City planning

description: Bees and other pollinating insects are increasingly at risk in agricultural spaces, due to years of intensive monocultures, pathogens, imported species and pesticides. New research identifies urban spaces as a bastion of insect biodiversity, but in order to maintain these precious species space must be made available to combat loss of habitat. As the spaces need not be large, radical and activist planning efforts to introduce pockets of wilderness in the cracks of the city may offer the best hope to maintain bees in urban environments.
description: https://viurrspace.ca/bitstream/handle/10613/8608/Delaney.pdf?sequence=3&isAllowed=y
A theoretical model of cytokinesis implicates feedback between membrane curvature and cytoskeletal organization in asymmetric cytokinetic furrowing
Creators: name: Maddox, Amy Shaub
name: Phi, Tan-Trao
name: Zhang, Li
name: Maddox, Paul S.
name: Liu, Jian
name: Dorn, Jonas F.
name: Lacroix, Benjamin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: During cytokinesis, the cell undergoes a dramatic shape change as it divides into two daughter cells. Cell shape changes in cytokinesis are driven by a cortical ring rich in actin filaments and nonmuscle myosin II. The ring closes via actomyosin contraction coupled with actin depolymerization. Of interest, ring closure and hence the furrow ingression are nonconcentric (asymmetric) within the division plane across Metazoa. This nonconcentricity can occur and persist even without preexisting asymmetric cues, such as spindle placement or cellular adhesions. Cell-autonomous asymmetry is not explained by current models. We combined quantitative high-resolution live-cell microscopy with theoretical modeling to explore the mechanistic basis for asymmetric cytokinesis in the Caenorhabditis elegans zygote, with the goal of uncovering basic principles of ring closure. Our theoretical model suggests that feedback among membrane curvature, cytoskeletal alignment, and contractility is responsible for asymmetric cytokinetic furrowing. It also accurately predicts experimental perturbations of conserved ring proteins. The model further suggests that curvature-mediated filament alignment speeds up furrow closure while promoting energy efficiency. Collectively our work underscores the importance of membrane–cytoskeletal anchoring and suggests conserved molecular mechanisms for this activity.
Neoteric authenticity: using urban magnets to create authenticity in new developments
Creators: name: Holland, Mark
name: Haden, Bruce
name: Irvine, Bruce
Publisher: name: Vancouver Island University - Royal Roads University
Year: 2018
Subjects: subject: City planning

description: This article addresses the issue of creating an experience of authenticity in new developments through the use of a land use and design concept called Urban Magnets. The authors, who are practitioners in planning, design and real estate development, challenge some of the conventional practices and assumptions in city planning, development and place making. Urban Magnets are special places focused around an activity-based subculture. These places include specialty retail, production, education and event uses for that subculture, and a physical design that supports their activities and reflects their identity. In response to the dynamic vitality of these subcultures, others come to watch and participate, and over time, these places become socially magnetic – attracting both the core subculture and many others. The foregrounding of the authentic identities and activities of an activity subculture create a strong sense of authenticity in urban space.
description: https://viurrspace.ca/bitstream/handle/10613/8609/Holland.pdf?sequence=3&isAllowed=y
Victoria's suburban sprawl as a barrier to sustainable development
Creators: name: Hindrichs, Lyra A.J,
Publisher: name: Vancouver Island University - Royal Roads University
Year: 2018
Subjects: subject: City planning

description: Canada is a nation where over two thirds of the population lives in some form of suburb (Gordon & Janzen 2013). It is important to monitor the locations of population growth within our nation as it has profound effects on our economic effectiveness, environmental sustainability, and our overall public health. The purpose of this study is to estimate Victoria’s 2016 suburban population using housing density and journey-to-work transportation data to classify the Census Metropolitan Area (CMA) into exurban, auto suburb, transit suburb, or active core. Using Transportation Method 9 (Gordon 2018), it was found that 74.9% of Victoria’s population lived in suburban settings in 2016, with 65.3% situated in auto suburbs at the time of the 2016 census. Victoria had Canada’s highest active transportation average at 16.9%, with the second highest being Kingston at 9.5%. The population living in Victoria’s active cores was 21%, a 4% increase from 2011 with only 17% active core.
description: https://viurrspace.ca/bitstream/handle/10613/8610/Hindrichs.pdf?sequence=3&isAllowed=y
COVID-19 and Common Identity
Creators: name: Toprakkiran, Selin
name: Gordils, Jonathan
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: covid-19
subject: intergroup contact
subject: intergroup relations
subject: prejudice
subject: social identity
subject: stereotypes

description: Includes: Data, syntax and measures
Temporal coherence and correlation of counterpropagating twin photons
Creators: name: Gatti, Alessandra
name: Corti, Tommaso
name: Brambilla, Enrico
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: This work analyses the temporal coherence and correlation of counterpropagating twin photons generated in a quasi-phase matched nonlinear cristal by spontaneous parametric-down conversion. We find out different pictures depending on the pump pulse duration relative to two characteristic temporal scales, determined respectively by the temporal separation between the counter-propagating and the co-propagating wavepackets. When the pump duration is intermediate between the two scales, we show a transition from a highly entangled state to an almost separable state, with strongly asymmetric spectral properties of the photons.
description: Submitted to Phys. Rev. A
Abelson kinase acts as a robust, multifunctional scaffold in regulating embryonic morphogenesis
Creators: name: Spracklen, Andrew J.
name: Schaefer, Kristina N.
name: Sumigray, Kaelyn D.
name: Peifer, Mark
name: Allred, S. Colby
name: Rogers, Edward M.
name: Ritchie, Benjamin J.
name: Bilancia, Colleen G.
name: Nowotarski, Stephanie H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Abelson family kinases (Abl) are key regulators of cell behavior and the cytoskeleton during development and in leukemia. Abl's SH3, SH2, and tyrosine kinase domains are joined via a linker to an F-actin-binding domain (FABD). Research on Abl's roles in cell culture led to several hypotheses for its mechanism of action: 1) Abl phosphorylates other proteins, modulating their activity. 2) Abl directly regulates the cytoskeleton via its cytoskeletal interaction domains, and/or 3) Abl is a scaffold for a signaling complex. The importance of these roles during normal development remains untested. We tested these mechanistic hypotheses during Drosophila morphogenesis using a series of mutants to examine Abl's many cell biological roles. Strikingly, Abl lacking the FABD fully rescued morphogenesis, cell shape change, actin regulation, and viability, while kinase dead Abl, though reduced in function, retained substantial rescuing ability in some but not all Abl functions. We also tested the function of four conserved motifs in the linker region, revealing a key role for a conserved PXXP motif known to bind Crk and Abi. We propose Abl acts as a robust multi-domain scaffold with different protein motifs and activities contributing differentially to diverse cellular behaviors.
[OPEN DATA REGISTRATION, PAPER] Preventing Recurrence of Depression: Long-Term effects of a Randomized Controlled Trial on Cognitive Control Training for Remitted Depressed Patients
Creators: name: Hoorelbeke, Kristof
name: Van den Bergh, Nathan
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Clinical Psychology
subject: Psychiatry and Psychology
subject: Medicine and Health Sciences
subject: Mental and Social Health
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: This is a frozen copy of a pre-registered project containing the data for following publication: Hoorelbeke, K., Van den Bergh, N., De Raedt, R., Wichers, M., & Koster, E.H.W. (2021). Preventing recurrence of depression: Long-term effects of a randomized controlled trial on cognitive control training for remitted depressed patients. Clinical Psychological Science.
title: CT-guided percutaneous cryoablation of renal tumours using a real time robotic tracking system: a good news for radiation dose
Creators: name: Quarchioni, Simone
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Interventional non-vascular
subject: Kidney
subject: Radioprotection / Radiation dose
subject: CT
subject: Percutaneous
subject: Ablation procedures
subject: Computer Applications-3D
subject: Efficacy studies

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Historically, radical nephrectomy was considered to be the treatment of choice renal tumors, even for those of small size (1). During the years, partial nephrectomy, has replaced this approach as it preserves the organ while offering the same...
ChromoShake: a chromosome dynamics simulator reveals that chromatin loops stiffen centromeric chromatin
Creators: name: Bloom, Kerry
name: Taylor, Russell M.
name: Lawrimore, Josh
name: Hahn, Patrick
name: Fulp, Alyona
name: Kompa, Ben
name: Vicci, Leandra
name: Aicher, Joseph K.
name: Falvo, Michael
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: A novel chromosome simulator recapitulates the position and dynamics of centromeric chromatin in a model composed of cross-linked intramolecular loops. Simulations reveal that chromatin loops stiffen the centromere and dictate the distribution of pericentric cohesin.ChromoShake is a three-dimensional simulator designed to find the thermodynamically favored states for given chromosome geometries. The simulator has been applied to a geometric model based on experimentally determined positions and fluctuations of DNA and the distribution of cohesin and condensin in the budding yeast centromere. Simulations of chromatin in differing initial configurations reveal novel principles for understanding the structure and function of a eukaryotic centromere. The entropic position of DNA loops mirrors their experimental position, consistent with their radial displacement from the spindle axis. The barrel-like distribution of cohesin complexes surrounding the central spindle in metaphase is a consequence of the size of the DNA loops within the pericentromere to which cohesin is bound. Linkage between DNA loops of different centromeres is requisite to recapitulate experimentally determined correlations in DNA motion. The consequences of radial loops and cohesin and condensin binding are to stiffen the DNA along the spindle axis, imparting an active function to the centromere in mitosis.
Clathrin binding by the adaptor Ent5 promotes late stages of clathrin coat maturation
Creators: name: Duncan, Mara C.
name: Hung, Chao-Wei
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Clathrin is a ubiquitous protein that mediates membrane traffic at many locations. To function, clathrin requires clathrin adaptors that link it to transmembrane protein cargo. In addition to this cargo selection function, many adaptors also play mechanistic roles in the formation of the transport carrier. However, the full spectrum of these mechanistic roles is poorly understood. Here we report that Ent5, an endosomal clathrin adaptor in Saccharomyces cerevisiae, regulates the behavior of clathrin coats after the recruitment of clathrin. We show that loss of Ent5 disrupts clathrin-dependent traffic and prolongs the lifespan of endosomal structures that contain clathrin and other adaptors, suggesting a defect in coat maturation at a late stage. We find that the direct binding of Ent5 with clathrin is required for its role in coat behavior and cargo traffic. Surprisingly, the interaction of Ent5 with other adaptors is dispensable for coat behavior but not cargo traffic. These findings support a model in which Ent5 clathrin binding performs a mechanistic role in coat maturation, whereas Ent5 adaptor binding promotes cargo incorporation.
title: Digital tomosynthesis imaging in temporo-mandibular joint dysfunction syndrome
Creators: name: Yang, Haitao
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Musculoskeletal joint
subject: Musculoskeletal bone
subject: Head and neck
subject: Digital radiography
subject: Image manipulation / Reconstruction
subject: Technology assessment
subject: Diagnostic procedure
subject: Imaging sequences
subject: Eating disorders
subject: Arthritides

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To explore the clinical application of digital tomosynthesis(DTS) in temporo-mandibular joint dysfunction syndrome (TMD), compared conventional digital...
Machine Learning based photometric redshifts for the KiDS ESO DR2 galaxies
Creators: name: Cavuoti, Stefano
name: Brescia, Massimo
name: Tortora, Crescenzo
name: Longo, Giuseppe
name: Napolitano, Nicola R.
name: Radovich, Mario
name: La Barbera, Francesco
name: Capaccioli, Massimo
name: de Jong, Jelte T. A.
name: Getman, Fedor
name: Grado, Aniello
name: Paolillo, Maurizio
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We estimated photometric redshifts (zphot) for more than 1.1 million galaxies of the ESO Public Kilo-Degree Survey (KiDS) Data Release 2. KiDS is an optical wide-field imaging survey carried out with the VLT Survey Telescope (VST) and the OmegaCAM camera, which aims at tackling open questions in cosmology and galaxy evolution, such as the origin of dark energy and the channel of galaxy mass growth. We present a catalogue of photometric redshifts obtained using the Multi Layer Perceptron with Quasi Newton Algorithm (MLPQNA) model, provided within the framework of the DAta Mining and Exploration Web Application REsource (DAMEWARE). These photometric redshifts are based on a spectroscopic knowledge base which was obtained by merging spectroscopic datasets from GAMA (Galaxy And Mass Assembly) data release 2 and SDSS-III data release 9. The overall 1 sigma uncertainty on Delta z = (zspec - zphot) / (1+ zspec) is ~ 0.03, with a very small average bias of ~ 0.001, a NMAD of ~ 0.02 and a fraction of catastrophic outliers (| Delta z | > 0.15) of ~0.4%.
description: MNRAS, 6 pages, 4 figures
title: Assessment of the effects of scanning and reconstruction parameters on bone densitometry results for single energy quantitative CT (qCT) scans in a phantom study
Creators: name: Hofmann, Philipp
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Musculoskeletal spine
subject: Bones
subject: Computer applications
subject: CT-Quantitative
subject: CT
subject: Absorptiometry / Bone densitometry
subject: Computer Applications-Detection, diagnosis
subject: Physics
subject: Osteoporosis
subject: Demineralisation-Bone

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: In developed countries across the world, higher average life expectancy coupled with increasingly sedentary lifestyles have contributed to the rise of osteoporosis[1]. The timely diagnosis of osteoporosis, and its predecessor osteopenia is difficult...
Quotients of surface groups and homology of finite covers via quantum representations
Creators: name: Koberda, Thomas
name: Santharoubane, Ramanujan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Geometric Topology (math.GT)
subject: Group Theory (math.GR)
subject: FOS: Mathematics

description: We prove that for each sufficiently complicated orientable surface $S$, there exists an infinite image linear representation $ρ$ of $π_1(S)$ such that if $γ\inπ_1(S)$ is freely homotopic to a simple closed curve on $S$, then $ρ(γ)$ has finite order. Furthermore, we prove that given a sufficiently complicated orientable surface $S$, there exists a regular finite cover $S'\to S$ such that $H_1(S',\mathbb{Z})$ is not generated by lifts of simple closed curves on $S$, and we give a lower bound estimate on the index of the subgroup generated by lifts of simple closed curves. We thus answer two questions posed by Looijenga, and independently by Kent, Kisin, Marché, and McMullen. The construction of these representations and covers relies on quantum $\text{SO}(3)$ representations of mapping class groups.
description: 22 pages, revised version. To appear in Inventiones mathematicae
Comparative assessment of fluorescent proteins for in vivo imaging in an animal model system
Creators: name: Higgins, Christopher D.
name: Kuhn, Jeffrey R.
name: Goldstein, Bob
name: Steward, Annette
name: Dickinson, Daniel J.
name: Ahringer, Julie
name: Pani, Ariel M.
name: Heppert, Jennifer K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Fluorescent protein tags are fundamental tools used to visualize gene products and analyze their dynamics in vivo. Recent advances in genome editing have expedited the precise insertion of fluorescent protein tags into the genomes of diverse organisms. These advances expand the potential of in vivo imaging experiments and facilitate experimentation with new, bright, photostable fluorescent proteins. Most quantitative comparisons of the brightness and photostability of different fluorescent proteins have been made in vitro, removed from biological variables that govern their performance in cells or organisms. To address the gap, we quantitatively assessed fluorescent protein properties in vivo in an animal model system. We generated transgenic Caenorhabditis elegans strains expressing green, yellow, or red fluorescent proteins in embryos and imaged embryos expressing different fluorescent proteins under the same conditions for direct comparison. We found that mNeonGreen was not as bright in vivo as predicted based on in vitro data but is a better tag than GFP for specific kinds of experiments, and we report on optimal red fluorescent proteins. These results identify ideal fluorescent proteins for imaging in vivo in C. elegans embryos and suggest good candidate fluorescent proteins to test in other animal model systems for in vivo imaging experiments.
Excess centrosomes perturb dynamic endothelial cell repolarization during blood vessel formation
Creators: name: Yu, Zhixian
name: Bautch, Victoria L.
name: Ferro, Luke S.
name: Kushner, Erich J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Blood vessel formation requires dynamic movements of endothelial cells (ECs) within sprouts. The cytoskeleton regulates migratory polarity, and centrosomes organize the microtubule cytoskeleton. However, it is not well understood how excess centrosomes, commonly found in tumor stromal cells, affect microtubule dynamics and interphase cell polarity. Here we find that ECs dynamically repolarize during sprouting angiogenesis, and excess centrosomes block repolarization and reduce migration and sprouting. ECs with excess centrosomes initially had more centrosome-derived microtubules but, paradoxically, fewer steady-state microtubules. ECs with excess centrosomes had elevated Rac1 activity, and repolarization was rescued by blockade of Rac1 or actomyosin blockers, consistent with Rac1 activity promoting cortical retrograde actin flow and actomyosin contractility, which precludes cortical microtubule engagement necessary for dynamic repolarization. Thus normal centrosome numbers are required for dynamic repolarization and migration of sprouting ECs that contribute to blood vessel formation.
title: Kernicterus, chronic bilirubin encephalophy: imaging features and clinical correlation.
Creators: name: Magalhães, Márcio
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Neuroradiology brain
subject: MR
subject: Imaging sequences
subject: Outcomes analysis

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Basically, Kernicterus or chronic bilirubin encephalopathy is a neurological disorder induced by its selective damage to the globus pallidus (the pars externa and interna), substancia nigra reticulata, subthalamic nucleus, brainstem...
Witnessing the birth of a supermassive protostar
Creators: name: Latif, Muhammad A.
name: Schleicher, Dominik R. G.
name: Hartwig, Tilman
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The detection of $\rm z>6$ quasars reveals the existence of supermassive black holes of a few $\rm 10^9~M_{\odot}$. One of the potential pathways to explain their formation in the infant universe is the so-called direct collapse model which provides massive seeds of $\rm 10^5-10^6~M_{\odot}$. An isothermal direct collapse mandates that halos should be of a primordial composition and the formation of molecular hydrogen remains suppressed in the presence of a strong Lyman Werner flux. In this study, we perform high resolution cosmological simulations for two massive primordial halos employing a detailed chemical model which includes $\rm H^-$ cooling as well as realistic opacities for both the bound-free $\rm H^-$ emission and the Rayleigh scattering of hydrogen atoms. We are able to resolve the collapse up to unprecedentedly high densities of $\rm \sim 10^{-3}~g/cm^3$ and to scales of about $\rm 10^{-4}$ AU. Our results show that the gas cools down to $\rm \sim $ 5000 K in the presence of $\rm H^-$ cooling, and induces fragmentation at scales of about 8000 AU in one of the two simulated halos, which may lead to the formation of a binary. In addition, fragmentation also occurs on the AU scale in one of the halos but the clumps are expected to merge on short time scales. Our results confirm that $\rm H^-$ cooling does not prevent the formation of a supermassive star and the trapping of cooling radiation stabilises the collapse on small scales.
description: Accpeted version, to appear in MNRAS, comments are still welcome and high resolution version is available at http://www2.iap.fr/users/latif/DCBH.pdf
title: Radiofrequency ablation with monopolar cluster vs bipolar multipolar electrodes for the treatment of ≥ 2.5 cm single hepatocellular carcinoma
Creators: name: Ahmad, Medhat
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Interventional non-vascular
subject: Ultrasound
subject: Ablation procedures
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To compare the effectiveness of radiofrequency ablation performed by a multipolar electrode and a cluster electrode for the treatment of single (≥2.5 cm) hepatocellular carcinoma in patients with...
Disk tracing for B[e] supergiants in the Magellanic Clouds
Creators: name: Maravelias, G.
name: Kraus, M.
name: Aret, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: B[e] supergiants are evolved massive stars with a complex circumstellar environment. A number of important emission features probe the structure and the kinematics of the circumstellar material. In our survey of Magellanic Cloud B[e] supergiants we focus on the [OI] and [CaII] emission lines, which we identified in four more objects.
description: 2 pages; 1 figure; submitted to the proceedings of the Physics of Evolved Stars - A conference dedicated to the memory of Olivier Chesneau, Nice, France, June 8-12, 2015
Kinetic theory of a longitudinally expanding system of scalar particles
Creators: name: Epelbaum, Thomas
name: Gelis, Francois
name: Jeon, Sangyong
name: Moore, Guy
name: Wu, Bin
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: A simple kinematical argument suggests that the classical approximation may be inadequate to describe the evolution of a system with an anisotropic particle distribution. In order to verify this quantitatively, we study the Boltzmann equation for a longitudinally expanding system of scalar particles interacting with a $ϕ^4$ coupling, that mimics the kinematics of a heavy ion collision at very high energy. We consider only elastic $2\to 2$ scatterings, and we allow the formation of a Bose-Einstein condensate in overpopulated situations by solving the coupled equations for the particle distribution and the particle density in the zero mode. For generic CGC-like initial conditions with a large occupation number and a moderate coupling, the solutions of the full Boltzmann equation do not follow a classical attractor behavior.
description: 26 figures, 47 pages
From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations
Creators: name: Brodsky, Jeffrey L.
name: Cutting, Garry R.
name: Cai, Zhiwei
name: Houck, Scott A.
name: Veit, Gudio
name: Sheppard, David N.
name: Chiang, Annette N.
name: Frizzell, Raymon A.
name: Avramescu, Radu G.
name: Skach, William R.
name: Hong, Jeong S.
name: Guggino, William B.
name: Sorscher, Eric J.
name: Cyr, Douglas M.
name: Balch, William E.
name: Lukacs, Gergely L.
name: Peters, Kathryn W.
name: Pollard, Harvey B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: More than 2000 mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) have been described that confer a range of molecular cell biological and functional phenotypes. Most of these mutations lead to compromised anion conductance at the apical plasma membrane of secretory epithelia and cause cystic fibrosis (CF) with variable disease severity. Based on the molecular phenotypic complexity of CFTR mutants and their susceptibility to pharmacotherapy, it has been recognized that mutations may impose combinatorial defects in CFTR channel biology. This notion led to the conclusion that the combination of pharmacotherapies addressing single defects (e.g., transcription, translation, folding, and/or gating) may show improved clinical benefit over available low-efficacy monotherapies. Indeed, recent phase 3 clinical trials combining ivacaftor (a gating potentiator) and lumacaftor (a folding corrector) have proven efficacious in CF patients harboring the most common mutation (deletion of residue F508, ΔF508, or Phe508del). This drug combination was recently approved by the U.S. Food and Drug Administration for patients homozygous for ΔF508. Emerging studies of the structural, cell biological, and functional defects caused by rare mutations provide a new framework that reveals a mixture of deficiencies in different CFTR alleles. Establishment of a set of combinatorial categories of the previously defined basic defects in CF alleles will aid the design of even more efficacious therapeutic interventions for CF patients.
title: Transjugular portosystemic shunt (TIPS) in cirrhotic patients with portal vein thrombosis
Creators: name: Perez Montilla, Maria Eugenia
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Interventional vascular
subject: Abdomen
subject: Fluoroscopy
subject: Shunts
subject: Cirrhosis

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The prevalence of portal vein thrombosis (PVT) in patients with cirrhosis ranges from 1 to 25%. Potential factors contributing to the risk of PVT include slow portal blood flow velocity characteristic of portal hypertension, and concomitant...
Replication of Pfattheicher (2020) Empathy within COVID-19 BYU-Idaho Winter 2021
Creators: name: Hill, Madisen
name: Galbraith, Tom
name: Randall, Taft
name: Yskes, Zach
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences

description: The replicators are Tom Galbraith, Madisen Hill, Taft Randall, and Zach Yskes. The study is being supervised by Dr. Brady Wiggins at Brigham Young University- Idaho. The study being replicated is The Emotional Path to Action: Empathy Promotes Physical Distancing and Wearing of Face Masks During the COVID-19 Pandemic. Authored by Stefan Pfattheicher, Laila Nockur, Robert Böhm, Claudia Sassenrath, and Michael Bang Peterson. We will be replicating the fourth study of their publication. The theory behind the original study is that people are more motivated to wear face masks and physically distance themselves from others when there is affective empathy, the ability to mentally understand how someone is feeling and responding appropriately, involved. In other words, when the individual is more empathetic, they are more motivated to take measures to protect others from the disease. When an individual is less empathetic, they will be less motivated to wear a face mask. Their theory behind this is that wearing a mask is a prosocial act, meaning that it has more protective effects to others than to oneself. Since empathy is also a prosocial attribute, the more empathetic one is, the more motivated they are to wear a mask. We will be conducting a replication of the original authors' fourth study. It will be conducted at Brigham Young University-Idaho with undergraduate introductory psychology students.