cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
(401634) John Denholm
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Feedback Interactions between Cell–Cell Adherens Junctions and Cytoskeletal Dynamics in Newt Lung Epithelial Cells
Creators: name: Salmon, E. D.
name: Salmon, Wendy C.
name: Waterman-Storer, Clare M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: To test how cell–cell contacts regulate microtubule (MT) and actin cytoskeletal dynamics, we examined dynamics in cells that were contacted on all sides with neighboring cells in an epithelial cell sheet that was undergoing migration as a wound-healing response. Dynamics were recorded using time-lapse digital fluorescence microscopy of microinjected, labeled tubulin and actin. In fully contacted cells, most MT plus ends were quiescent; exhibiting only brief excursions of growth and shortening and spending 87.4% of their time in pause. This contrasts MTs in the lamella of migrating cells at the noncontacted leading edge of the sheet in which MTs exhibit dynamic instability. In the contacted rear and side edges of these migrating cells, a majority of MTs were also quiescent, indicating that cell–cell contacts may locally regulate MT dynamics. Using photoactivation of fluorescence techniques to mark MTs, we found that MTs in fully contacted cells did not undergo retrograde flow toward the cell center, such as occurs at the leading edge of motile cells. Time-lapse fluorescent speckle microscopy of fluorescently labeled actin in fully contacted cells revealed that actin did not flow rearward as occurs in the leading edge lamella of migrating cells. To determine if MTs were required for the maintenance of cell–cell contacts, cells were treated with nocodazole to inhibit MTs. After 1–2 h in either 10 μM or 100 nM nocodazole, breakage of cell–cell contacts occurred, indicating that MT growth is required for maintenance of cell–cell contacts. Analysis of fixed cells indicated that during nocodazole treatment, actin became reduced in adherens junctions, and junction proteins α- and β-catenin were lost from adherens junctions as cell–cell contacts were broken. These results indicate that a MT plus end capping protein is regulated by cell–cell contact, and in turn, that MT growth regulates the maintenance of adherens junctions contacts in epithelia.
title: Cysts of the Lower GU Tract: Pearls and Pitfalls in Imaging, Diagnosis, and Management
Creators: name: Shinnawi, Samir
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Genital / Reproductive system female
subject: Genital / Reproductive system male
subject: Urinary Tract / Bladder
subject: CT
subject: MR
subject: Ultrasound
subject: Education
subject: eLearning
subject: Congenital
subject: Cysts
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: The viewer will learn to: 1) recognize relevant anatomic landmarks of the female and male pelvic floor 2) describe key imaging features and differential diagnosis of lower GU-tract common cystic lesions 4) prevent unnecessary interventions. 5) help...
Developments in Farm to Retail Price Spreads for Food Products in 1982
Creators: name: Dunham, Denis
name: Dunham, Denis
Publisher: name: Unknown
Year: 1993
Subjects: subject: Food Consumption/Nutrition/Food Safety
subject: Marketing
subject: FOS: Economics and business
subject: Production Economics
subject: Farm to retail price spread
subject: Farm value
subject: Food marketing costs
subject: Retail food prices
subject: Margins
subject: Profit
subject: Productivity

description: Retail grocery food prices Increased 3.4 percent In 1982, half the 1981 rate and the least in 6 years. The slowdown reflected abundant supplies of farm products, weak demand, and a smaller rise in fish and Imported food prices. The farm value of USDA's market basket of foods rose only 1 percent in 1982. Farm values for most foods fell although those of fresh fruit and pork increased sharply. The farm-value share of a dollar spent at foodstores remained low at 35 percent. The farm to retail price spread of USDA's market basket of foods rose by 5.1 percent, the slowest in 5 years. Food industry marketing costs increased at half their 1981 rate, largely because of a slower rise in wages.
On construction of unitary quantum group differential calculus
Creators: name: Pyatov, Pavel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Algebra (math.QA)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 58B32, 81R50

description: We develop a construction of the unitary type anti-involution for the quantized differential calculus over $GL_q(n)$ in the case $|q|=1$. To this end, we consider a joint associative algebra of quantized functions, differential forms and Lie derivatives over $GL_q(n)/SL_q(n)$, which is bicovariant with respect to $GL_q(n)/SL_q(n)$ coactions. We define a specific non-central {\em spectral extension} of this algebra by the spectral variables of three matrices of the algebra generators. In the spectrally expended algebra we construct three-parametric family of its inner automorphisms. These automorphisms are used for construction of the unitary anti-involution for the (spectrally extended) calculus over $GL_q(n)$.
description: 26 pages, no figures
Identification of Novel, Evolutionarily Conserved Cdc42p-interacting Proteins and of Redundant Pathways Linking Cdc24p and Cdc42p to Actin Polarization in Yeast
Creators: name: Pringle, John R.
name: Chen, Guang Chao
name: Chiavetta, John B.
name: Chen, Herman
name: Bi, Erfei
name: Chan, Clarence S.M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: In the yeast Saccharomyces cerevisiae, Cdc24p functions at least in part as a guanine-nucleotide-exchange factor for the Rho-family GTPase Cdc42p. A genetic screen designed to identify possible additional targets of Cdc24p instead identified two previously known genes, MSB1 and CLA4, and one novel gene, designated MSB3, all of which appear to function in the Cdc24p–Cdc42p pathway. Nonetheless, genetic evidence suggests that Cdc24p may have a function that is distinct from its Cdc42p guanine-nucleotide-exchange factor activity; in particular, overexpression of CDC42 in combination with MSB1 or a truncated CLA4 in cells depleted for Cdc24p allowed polarization of the actin cytoskeleton and polarized cell growth, but not successful cell proliferation. MSB3 has a close homologue (designated MSB4) and two more distant homologues (MDR1 and YPL249C) in S. cerevisiae and also has homologues in Schizosaccharomyces pombe, Drosophila (pollux), and humans (the oncogene tre17). Deletion of either MSB3 or MSB4 alone did not produce any obvious phenotype, and the msb3 msb4 double mutant was viable. However, the double mutant grew slowly and had a partial disorganization of the actin cytoskeleton, but not of the septins, in a fraction of cells that were larger and rounder than normal. Like Cdc42p, both Msb3p and Msb4p localized to the presumptive bud site, the bud tip, and the mother-bud neck, and this localization was Cdc42p dependent. Taken together, the data suggest that Msb3p and Msb4p may function redundantly downstream of Cdc42p, specifically in a pathway leading to actin organization. From previous work, the BNI1, GIC1, and GIC2 gene products also appear to be involved in linking Cdc42p to the actin cytoskeleton. Synthetic lethality and multicopy suppression analyses among these genes, MSB, and MSB4, suggest that the linkage is accomplished by two parallel pathways, one involving Msb3p, Msb4p, and Bni1p, and the other involving Gic1p and Gic2p. The former pathway appears to be more important in diploids and at low temperatures, whereas the latter pathway appears to be more important in haploids and at high temperatures.
Accuracy of substance exposure history in patients attending emergency departments after substance misuse; a comparison with biological sample analysis
Creators: name: Virmani, Ishita
name: Oteo, Alberto
name: Dunn, Michael
name: Vidler, Daniel
name: Roper, Clair
name: Officer, Jane
name: Hardy, Gareth
name: Dargan, Paul I.
name: Eddleston, Michael
name: Cooper, Jamie G.
name: Hill, Simon L.
name: Macfarlane, Rebecca
name: Keating, Liza
name: Haden, Mark
name: Hudson, Simon
name: Thomas, Simon H. L.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Acute toxicity caused by illicit substance use is a common reason for emergency department (ED) presentation. Knowledge of the substances involved is helpful for predicting and managing potential toxicity, but limited information is available about the accuracy of patient-reported substance exposure. This study assessed the accuracy of the history of exposure in those reporting use of a single substance by comparison with those identified by detailed toxicological analysis, focusing on synthetic cannabinoid receptor agonists (SCRA). Adults (≥16 years) presenting between March 2015 and July 2021 to participating UK hospitals with toxicity after reporting use of a single illicit substance were included. Exposure details were documented from medical records and blood and/or urine samples analysed using high-resolution accurate mass liquid chromatography-mass spectrometry (HRAM LCMS). Sensitivity, specificity, and positive and negative predictive values of the exposure history were calculated by comparison with biological sample analysis (“gold standard”). Single substance exposure was reported for 474 (median age 33 years, IQR: 18 range 16–75, 80% males) patients. Analysis commonly identified multiple substances (Median 3, IQR 2–5). A history of exposure was documented for 121 of 151 patients where a SCRA or metabolite was detected on analysis (sensitivity 80.1%, 95% CI 72.9, 86.2%). Corresponding proportions were lower for 3,4-methylenedioxymethamphetamine (MDMA, 44/70, 62.9%., 95% CI 50.5%, 74.1%), heroin 41/108 (38.0% 95% CI 28.8–47.8%) and cocaine (22/56, 31.3%, 95% CI 20.9, 43.6%). Multiple undeclared substances were detected analytically in most patients reporting single substance use. Clinicians should be alert to the potential presence and toxicity of unreported substances when managing patients presenting after substance misuse.
title: Variability in dimension and volume of pulmonary mass at different kVp
Creators: name: Dangal, Anjan
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Lung
subject: Radiographers
subject: CT
subject: Diagnostic procedure
subject: Statistics
subject: FOS: Mathematics
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Pulmonary mass or lung cancer is the leading cause of mortality worldwide and is a strong economic burden [1] . The pulmonary mass can differ in origin, attenuation, shape, appearance, and size, which can determine the malignancy, growth rate, and...
Broadband, unpolarized repumping and clearout light sources for Sr$^+$ single-ion clocks
Creators: name: Fordell, T.
name: Lindvall, T.
name: Dubé, P.
name: Madej, A. A.
name: Wallin, A. E.
name: Merimaa, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: Future transportable optical clocks require compact and reliable light sources. Here, broadband, unpolarized repumper and state clearout sources for Sr+ single-ion optical clocks are reported. These turn-key devices require no frequency stabilization nor external modulators. They are fiber based, inexpensive, and compact. Key characteristics for clock operation are presented, including optical spectra, induced light shifts and required extinction ratios. Tests with an operating single-ion standard show a clearout efficiency of 100%. Compared to a laser-based repumper, the achievable fluorescence rates for ion detection are a few tens of per cent lower. The resulting ion kinetic temperature is 1--1.5 mK, near the Doppler limit of the ion system. Similar repumper light sources could be made for Ca+ (866 nm) and Ba+ (650 nm) using semiconductor gain media.
description: 4 pages, 6 figures
Predictions for reverberating spectral line from a newly formed black hole accretion disk: case of tidal disruption flares
Creators: name: Zhang, Wenda
name: Yu, Wenfei
name: Karas, Vladimir
name: Dovciak, Michal
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Tidal Disruption Events (TDEs) can be perfect probes of dormant SMBHs in normal galaxies. During the rising phase, the accretion luminosity can increase by orders of magnitude in several weeks and the emergent ionizing radiation illuminates the fresh accretion flow. In this paper, we simulated the evolution of the expected spectral line profile of iron due to such a flare by using a ray-tracing code with effects of general relativity (GR) taken into account. We found that the time-dependent profile changes significantly with black hole spin, inclination angle with respect to the black-hole equatorial plane, and the expansion velocity of the ionization front. At low values of spin, a "loop" feature appears in the line profile vs. time plot when the inclination is no less than $30^\circ$ and the expansion velocity $v_{\rm exp}$ is no less than half speed of light, due to a shadow in the emission of the truncated disk. In the light curve two peaks occur depending on the inclination angle. At large $v_{\rm exp}$, a shallow "nose" feature may develop ahead of the loop, its duration depends on the expansion velocity and the inclination angle. We explore the entire interval of black hole spin parameter ranging from extreme prograde to extreme retrograde rotation, $-1
description: 12 pages, including 8 figures, accepted for publication in ApJ
title: Enhanced separation of brain tumors and edema via diffusion tensor distribution imaging: Illustration with lymphoma cases
Creators: name: Syed Nasser, Nisha
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Neuroradiology brain
subject: MR-Diffusion/Perfusion
subject: Experimental investigations
subject: Lymphoma

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Specific assessments of tissue microstructure are key to differentiating diseased and healthy tissues. For instance, tumors exhibit startling structural heterogeneity both on the macroscopic and microscopic scales [1].Clinical diagnoses of brain...
The equivariant Cuntz semigroup
Creators: name: Gardella, Eusebio
name: Santiago, Luis
Publisher: name: arXiv
Year: 2015
Subjects: subject: Operator Algebras (math.OA)
subject: Dynamical Systems (math.DS)
subject: Functional Analysis (math.FA)
subject: FOS: Mathematics

description: We introduce an equivariant version of the Cuntz semigroup, that takes an action of a compact group into account. The equivariant Cuntz semigroup is naturally a semimodule over the representation semiring of the given group. Moreover, this semimodule satisfies a number of additional structural properties. We show that the equivariant Cuntz semigroup, as a functor, is continuous and stable. Moreover, cocycle conjugate actions have isomorphic associated equivariant Cuntz semigroups. One of our main results is an analog of Julg's theorem: the equivariant Cuntz semigroup is canonically isomorphic to the Cuntz semigroup of the crossed product. We compute the induced semimodule structure on the crossed product, which in the abelian case is given by the dual action. As an application of our results, we show that freeness of a compact Lie group action on a compact Hausdorff space can be characterized in terms of a canonically defined map into the equivariant Cuntz semigroup, extending results of Atiyah and Segal for equivariant $K$-theory. Finally, we use the equivariant Cuntz semigroup to classify locally representable actions on direct limits of one-dimensional NCCW-complexes, generalizing work of Handelman and Rossmann.
description: 56 pages. Version 2: minor corrections. To appear in Proceedings of the London Mathematical Society
(401635) Martha Govan
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Feasibility study of “Dark-blood”of IQon spectral CT coronary CTA for coronary artery wall imaging
Creators: name: Lin, Haitao
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Cardiac
subject: CAD
subject: Colonography CT
subject: Blood

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Coronary CTA is the preferred screening method for coronary heart disease. It plays an important role in the diagnosis and follow-up treatment of coronary stenosis. With the improvement of CT performance and the optimization of image quality, the...
Paxillin Binding Is Not the Sole Determinant of Focal Adhesion Localization or Dominant-Negative Activity of Focal Adhesion Kinase/Focal Adhesion Kinase-related Nonkinase
Creators: name: Schaller, M. D.
name: Ohngemach, C.
name: Broome, J. M.
name: Cooley, M. A.
name: Romer, L. H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: The carboxy-terminal 150 residues of the focal adhesion kinase (FAK) comprise the focal adhesion-targeting sequence, which is responsible for its subcellular localization. The mechanism of focal adhesion targeting has not been fully elucidated. We describe a mutational analysis of the focal adhesion-targeting sequence of FAK to further examine the mechanism of focal adhesion targeting and explore additional functions encoded by the carboxy-terminus of FAK. The results demonstrate that paxillin binding is dispensable for focal adhesion targeting of FAK. Cell adhesion-dependent tyrosine phosphorylation strictly correlated with the ability of mutants to target to focal adhesions. Focal adhesion targeting was also a requirement for maximal FAK-dependent tyrosine phosphorylation of paxillin and FAK-related nonkinase (FRNK)–dependent inhibition of endogenous FAK function. However, there were additional requirements for these latter functions because we identified mutants that target to focal adhesions, yet are defective for the induction of paxillin phosphorylation or the dominant-negative function of FRNK. Furthermore, the paxillin-binding activity of FRNK mutants did not correlate with their ability to inhibit FAK, suggesting that FRNK has other targets in addition to paxillin.
title: Quantitative T1rho MR imaging detects early changes in advanced-stage nasopharyngeal carcinoma treated with chemotherapy
Creators: name: AI, Qi Yong
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Head and neck
subject: MR-Functional imaging
subject: Treatment effects
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Locoregional relapse remains an important determinant of failure in nasopharyngeal carcinoma (NPC). Functional magnetic resonance imaging (MRI), such as diffusion weighted imaging, produces imaging biomarkers and show changes in parameters can be...
title: Implementation Of Fast Echo-planar Imaging (EPImix) MRI Sequence For Scan Time Reduction In Critical And Unco-operative Patients
Creators: name: Syed Nasser, Nisha
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Neuroradiology brain
subject: MR
subject: Experimental investigations
subject: Imaging sequences
subject: Dementia
subject: Seizure disorders
subject: Speech disorders

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: In MR imaging, long scan timing is a major drawback, limiting its clinical use in critical and uncooperative patients, as it can cause patient discomfort. Thus, achieving high-speed imaging while maintaining adequate image quality is of foremost...
A Millennial Myosin Census
Creators: name: Powell, B. C.
name: Cheney, R. E.
name: Berg, J. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: The past decade has seen a remarkable explosion in our knowledge of the size and diversity of the myosin superfamily. Since these actin-based motors are candidates to provide the molecular basis for many cellular movements, it is essential that motility researchers be aware of the complete set of myosins in a given organism. The availability of cDNA and/or draft genomic sequences from humans, Drosophila melanogaster, Caenorhabditis elegans, Arabidopsis thaliana, Saccharomyces cerevisiae, Schizosaccharomyces pombe, and Dictyostelium discoideum has allowed us to tentatively define and compare the sets of myosin genes in these organisms. This analysis has also led to the identification of several putative myosin genes that may be of general interest. In humans, for example, we find a total of 40 known or predicted myosin genes including two new myosins-I, three new class II (conventional) myosins, a second member of the class III/ninaC myosins, a gene similar to the class XV deafness myosin, and a novel myosin sharing at most 33% identity with other members of the superfamily. These myosins are in addition to the recently discovered class XVI myosin with N-terminal ankyrin repeats and two human genes with similarity to the class XVIII PDZ-myosin from mouse. We briefly describe these newly recognized myosins and extend our previous phylogenetic analysis of the myosin superfamily to include a comparison of the complete or nearly complete inventories of myosin genes from several experimentally important organisms.
(401631) James Smith Mack
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Dual Source Photon Counting Detector CT, What the Radiographer Needs to Know: First Clinical Experience in Comparison to Conventional Energy Integrating Detector CT.
Creators: name: Dijkshoorn, Marcel L.
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Radiographers
subject: CT
subject: Comparative studies
subject: Physics
subject: Technical aspects
subject: Education and training
subject: Kv imaging

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To describe the technical aspects and characteristics of photon-counting detectors. To learn how photon-counting CT affects key image quality parameters, such as spatial resolution and contrast-to-noise ratio. To understand how dual source...
Octupolar invariants for compact binaries on quasi-circular orbits
Creators: name: Nolan, Patrick
name: Kavanagh, Chris
name: Dolan, Sam R
name: Ottewill, Adrian C
name: Warburton, Niels
name: Wardell, Barry
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We extend the gravitational self-force methodology to identify and compute new $O(μ)$ tidal invariants for a compact body of mass $μ$ on a quasi-circular orbit about a black hole of mass $M \gg μ$. In the octupolar sector we find seven new degrees of freedom, made up of 3+3 conservative/dissipative `electric' invariants and 3+1 `magnetic' invariants, satisfying 1+1 and 1+0 trace conditions. After formulating for equatorial circular orbits on Kerr spacetime, we calculate explicitly for Schwarzschild spacetime. We employ both Lorenz gauge and Regge-Wheeler gauge numerical codes, and the functional series method of Mano, Suzuki and Takasugi. We present (i) highly-accurate numerical data and (ii) high-order analytical post-Newtonian expansions. We demonstrate consistency between numerical and analytic results, and prior work. We explore the application of these invariants in effective one-body models, and binary black hole initial-data formulations, and conclude with a discussion of future work.
description: 24 pages, 3 figures, 4 tables
ASH1 mRNA Localization in Three Acts
Creators: name: Bloom, K.
name: Beach, D. L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Novel green fluorescent protein (GFP) labeling techniques targeting specific mRNA transcripts reveal discrete phases of mRNA localization in yeast: packaging, transport, and docking. In budding yeast, ASH1 mRNA is translocated via actin and myosin to the tip of growing cells. A GFP-decorated reporter transcript containing the ASH1 3′ untranslated region gRNAASH1 forms spots of fluorescence localized to a cortical domain at the bud tip, relocates to the mother-bud neck before cell separation, and finally migrates to the incipient bud site before the next budding cycle. The correct positioning of the mRNA requires at least six proteins: She1p-5p and Bud6p/Aip3p. gRNAASH1 localization in mutant strains identified three functional categories for the She proteins: mRNA particle formation (She2p and She4p), mRNA transport into the bud (She1p/Myo4p and She3p), and mRNA tethering at the bud tip (She5p/Bni1p and Bud6p/Aip3p). Because localization of the mRNA within the bud does not a priori restrict the translated protein, we examine the distribution of a mother-specific protein (Yta6p) translated from a mRNA directed into the bud. Yta6p remains associated with the mother cortex despite localization of the mRNA to the bud. This video essay traces the life history of a localized mRNA transcript, describes the roles of proteins required to polarize and anchor the mRNA, and demonstrates at least one instance where mRNA localization does not effect protein localization.
title: Safety circuit for outpatient interventional procedures in imaging diagnostic environment in a tertiary hospital setting during the SARS-CoV-2 pandemic
Creators: name: Calvo, Raquel
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Interventional non-vascular
subject: CT
subject: Fluoroscopy
subject: Ultrasound
subject: Biopsy
subject: Epidemiology

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Our objective is to identify patients with a positive PCR test (Polymerase Chain Reaction) for SARS-CoV-2 before undergoing an outpatient interventional or sedation procedure in the diagnostic imaging department of the Hospital Clínic of Barcelona,...
On the Liouville theorem for weak Beltrami flows
Creators: name: Chae, Dongho
name: Wolf, Jörg
Publisher: name: arXiv
Year: 2015
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 76B03, 35Q31

description: We study Beltrami flows in the setting of weak solution to the stationary Euler equations in $\Bbb R^3$. For this weak Beltrami flow we prove the regularity and the Liouville property. In particular, we show that if tangential part of the velocity has certain decay property at infinity, then the solution becomes trivial. This decay condition of of the velocity is weaker than the previously known sufficient conditions for the Liouville property of the Betrami flows. For the proof we establish a mean value formula and other various formula for the tangential and the normal components of the weak solutions to the stationary Euler equations.
description: 10 pages
PSSOH Agenda 2020
Creators: name: Miljković, Nadica
name: Pejović, Predrag
name: Cvetanović, Miloš
Publisher: name: Zenodo
Year: 2020
Subjects: free software
open-source software
open hardware
electrical engineering
computer science
gender equality
open science

description: Tentative agenda for the third PSSOH conference (http://pssoh.etf.bg.ac.rs/) in English and in Serbian. Preliminarna agenda za treću PSSOH konferenciju (http://pssoh.etf.bg.ac.rs/) na engleskom i srpskom jeziku.
description: Version 8 contains corrected title. Verzija 8 sadrži korigovan naslov.
(401633) Margaret Hutcheson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Bud8p and Bud9p, Proteins That May Mark the Sites for Bipolar Budding in Yeast
Creators: name: Bussey, H.
name: Schenkman, L. R.
name: Shaw, S.
name: Harkins, H. A.
name: De Virgilio, C.
name: Pagé, N.
name: Pringle, J. R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: The bipolar budding pattern of a/α Saccharomyces cerevisiae cells appears to depend on persistent spatial markers in the cell cortex at the two poles of the cell. Previous analysis of mutants with specific defects in bipolar budding identified BUD8 and BUD9 as potentially encoding components of the markers at the poles distal and proximal to the birth scar, respectively. Further genetic analysis reported here supports this hypothesis. Mutants deleted for BUD8 or BUD9 grow normally but bud exclusively from the proximal and distal poles, respectively, and the double-mutant phenotype suggests that the bipolar budding pathway has been totally disabled. Moreover, overexpression of these genes can cause either an increased bias for budding at the distal (BUD8) or proximal (BUD9) pole or a randomization of bud position, depending on the level of expression. The structures and localizations of Bud8p and Bud9p are also consistent with their postulated roles as cortical markers. Both proteins appear to be integral membrane proteins of the plasma membrane, and they have very similar overall structures, with long N-terminal domains that are both N- and O-glycosylated followed by a pair of putative transmembrane domains surrounding a short hydrophilic domain that is presumably cytoplasmic. The putative transmembrane and cytoplasmic domains of the two proteins are very similar in sequence. When Bud8p and Bud9p were localized by immunofluorescence and tagging with GFP, each protein was found predominantly in the expected location, with Bud8p at presumptive bud sites, bud tips, and the distal poles of daughter cells and Bud9p at the necks of large-budded cells and the proximal poles of daughter cells. Bud8p localized approximately normally in several mutants in which daughter cells are competent to form their first buds at the distal pole, but it was not detected in a bni1 mutant, in which such distal-pole budding is lost. Surprisingly, Bud8p localization to the presumptive bud site and bud tip also depends on actin but is independent of the septins.
Dicentric Chromosome Stretching during Anaphase Reveals Roles of Sir2/Ku in Chromatin Compaction in Budding Yeast
Creators: name: Bloom, K.
name: Thrower, D. A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: We have used mitotic spindle forces to examine the role of Sir2 and Ku in chromatin compaction. Escherichia coli lac operator DNA was placed between two centromeres on a conditional dicentric chromosome in budding yeast cells and made visible by expression of a lac repressor–green fluorescent fusion protein. Centromeres on the same chromatid of a dicentric chromosome attach to opposite poles ∼50% of the time, resulting in chromosome bridges during anaphase. In cells deleted for yKU70, yKU80, or SIR2, a 10-kb region of the dicentric chromosome stretched along the spindle axis to a length of 6 μm during anaphase. On spindle disassembly, stretched chromatin recoiled to the bud neck and was partitioned to mother and daughter cells after cytokinesis and cell separation. Chromatin immunoprecipitation revealed that Sir2 localizes to the lacO region in response to activation of the dicentric chromosome. These findings indicate that Ku and Sir proteins are required for proper chromatin compaction within regions of a chromosome experiencing tension or DNA damage. The association of Sir2 with the affected region suggests a direct role in this process, which may include the formation of heterochromatic DNA.
Microtubule-dependent Changes in Assembly of Microtubule Motor Proteins and Mitotic Spindle Checkpoint Proteins at PtK1 Kinetochores
Creators: name: Pearson, C. G.
name: Howell, B. J.
name: Hoffman, D. B.
name: Salmon, E. D.
name: Yen, T. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: The ability of kinetochores to recruit microtubules, generate force, and activate the mitotic spindle checkpoint may all depend on microtubule- and/or tension-dependent changes in kinetochore assembly. With the use of quantitative digital imaging and immunofluorescence microscopy of PtK1 tissue cells, we find that the outer domain of the kinetochore, but not the CREST-stained inner core, exhibits three microtubule-dependent assembly states, not directly dependent on tension. First, prometaphase kinetochores with few or no kinetochore microtubules have abundant punctate or oblate fluorescence morphology when stained for outer domain motor proteins CENP-E and cytoplasmic dynein and checkpoint proteins BubR1 and Mad2. Second, microtubule depolymerization induces expansion of the kinetochore outer domain into crescent and ring morphologies around the centromere. This expansion may enhance recruitment of kinetochore microtubules, and occurs with more than a 20- to 100-fold increase in dynein and relatively little change in CENP-E, BubR1, and Mad2 in comparison to prometaphase kinetochores. Crescents disappear and dynein decreases substantially upon microtubule reassembly. Third, when kinetochores acquire their full metaphase complement of kinetochore microtubules, levels of CENP-E, dynein, and BubR1 decrease by three- to sixfold in comparison to unattached prometaphase kinetochores, but remain detectable. In contrast, Mad2 decreases by 100-fold and becomes undetectable, consistent with Mad2 being a key factor for the “wait-anaphase” signal produced by unattached kinetochores. Like previously found for Mad2, the average amounts of CENP-E, dynein, or BubR1 at metaphase kinetochores did not change with the loss of tension induced by taxol stabilization of microtubules.
RhoA Inactivation by p190RhoGAP Regulates Cell Spreading and Migration by Promoting Membrane Protrusion and Polarity
Creators: name: Arthur, W. T.
name: Burridge, K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: The binding of extracellular matrix proteins to integrins triggers rearrangements in the actin cytoskeleton by regulating the Rho family of small GTPases. The signaling events that mediate changes in the activity of Rho proteins in response to the extracellular matrix remain largely unknown. We have demonstrated in previous studies that integrin signaling transiently suppresses RhoA activity through stimulation of p190RhoGAP. Here, we investigated the biological significance of adhesion-dependent RhoA inactivation by manipulating p190RhoGAP signaling in Rat1 fibroblasts. The inhibition of RhoA activity that is induced transiently by adhesion was antagonized by expression of dominant negative p190RhoGAP. This resulted in impaired cell spreading on a fibronectin substrate, reduced cell protrusion, and premature assembly of stress fibers. Conversely, overexpression of p190RhoGAP augmented cell spreading. Dominant negative p190RhoGAP elevated RhoA activity in cells on fibronectin and inhibited migration, whereas overexpression of the wild-type GAP decreased RhoA activity, promoted the formation of membrane protrusions, and enhanced motility. Cells expressing dominant negative p190RhoGAP, but not control cells or cells overexpressing the wild-type GAP, were unable to establish polarity in the direction of migration. Taken together, these data demonstrate that integrin-triggered RhoA inhibition by p190RhoGAP enhances spreading and migration by regulating cell protrusion and polarity.
(401629) James Hagarty
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Influence of statistics on the measured moments of conserved quantities in relativistic heavy ion collisions
Creators: name: Chen, Lizhu
name: Li, Zhiming
name: Zhong, Xia
name: He, Yuncun
name: Wu, Yuanfang
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We study statistics dependence of the probability distributions and the means of measured moments of conserved quantities, respectively. The required statistics of all interested moments and their products are estimated based on a simple simulation. We also explain why the measured moments are underestimated when the statistics are insufficient.With the statistics at RHIC/BES, the second and third order moments can be reliably obtained based on the method of Centrality bin width correction (CBWC), which can not be applied for the fourth order moments at low energy. With planning statistics at RHIC/BES II, and improved CBWC method, $κσ^2$ in a finer centrality bin scale should be measurable. This will help us to understand the current observation of energy and centrality dependence of high-order moments.
description: 11 pages, 6 figures
title: Neuroblastoma in paediatric patients, emphasis on extra-adrenal forms
Creators: name: Dumbadze, Anna
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Paediatric
subject: Retroperitoneum
subject: CT
subject: MR
subject: Contrast agent-intravenous
subject: Education
subject: Staging
subject: Education and training
subject: Metastases
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To review the International Neuroblastoma Pathology Classification and International Neuroblastoma Staging System (INSS) To review the International Neuroblastoma Risk Group Staging System (INRGSS) and emphasize the role of imaging To review the...
Roles of a Fimbrin and an α-Actinin-like Protein in Fission Yeast Cell Polarization and Cytokinesis
Creators: name: Bähler, J.
name: Wu, J. Q.
name: Pringle, J. R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Eukaryotic cells contain many actin-interacting proteins, including the α-actinins and the fimbrins, both of which have actin cross-linking activity in vitro. We report here the identification and characterization of both an α-actinin-like protein (Ain1p) and a fimbrin (Fim1p) in the fission yeast Schizosaccharomyces pombe. Ain1p localizes to the actomyosin-containing medial ring in an F-actin–dependent manner, and the Ain1p ring contracts during cytokinesis. ain1 deletion cells have no obvious defects under normal growth conditions but display severe cytokinesis defects, associated with defects in medial-ring and septum formation, under certain stress conditions. Overexpression of Ain1p also causes cytokinesis defects, and the ain1 deletion shows synthetic effects with other mutations known to affect medial-ring positioning and/or organization. Fim1p localizes both to the cortical actin patches and to the medial ring in an F-actin–dependent manner, and several lines of evidence suggest that Fim1p is involved in polarization of the actin cytoskeleton. Although a fim1 deletion strain has no detectable defect in cytokinesis, overexpression of Fim1p causes a lethal cytokinesis defect associated with a failure to form the medial ring and concentrate actin patches at the cell middle. Moreover, an ain1 fim1 double mutant has a synthetical-lethal defect in medial-ring assembly and cell division. Thus, Ain1p and Fim1p appear to have an overlapping and essential function in fission yeast cytokinesis. In addition, protein-localization and mutant-phenotype data suggest that Fim1p, but not Ain1p, plays important roles in mating and in spore formation.
Direct Evidence of Washing out of Nuclear Shell Effects
Creators: name: Chaudhuri, A.
name: Ghosh, T. K.
name: Banerjee, K.
name: Bhattacharya, S.
name: Sadhukhan, Jhilam
name: Bhattacharya, C.
name: Kundu, S.
name: Meena, J. K.
name: Mukherjee, G.
name: Pandey, R.
name: Rana, T. K.
name: Roy, P.
name: Roy, T.
name: Srivastava, V.
name: Bhattacharya, P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Constraining excitation energy at which nuclear shell effect washes out has important implications on the production of super heavy elements and many other fields of nuclear physics research. We report the fission fragment mass distribution in alpha induced reaction on an actinide target for wide excitation range in close energy interval and show direct evidence that nuclear shell effect washes out at excitation energy ~40 MeV. Calculation shows that second peak of the fission barrier also vanishes around similar excitation energy.
description: 7 pages, 7 figures, Physical Review C (in press)
title: Using Electron Paramagnetic Resonance EPR to Investigate the Mechanisms of Action in Combination Therapy using Everolimus and 177Lu-DOTATOC/TATEfor the Treatment of Neuroendocrine Tumors
Creators: name: Al Rowaily, Mohammed
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Nuclear medicine
subject: Nuclear medicine conventional
subject: Radiation therapy / Oncology
subject: Outcomes

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Radiopharmaceuticals are used to carry unstable radionuclides close to target cells. The decay of the radionuclide causes the formation of radicals and, hopefully, to cancer cells death. However, little or no studies are present in literature...
China's precarious path forward – insights from the MERICS China Forecast 2023
Creators: name: Kefferpütz, Roderick
Publisher: name: Zenodo
Year: 2023
Subjects: China
EU-China relations
Forecast 2023

description: Unbridled power in the hands of Xi Jinping, underlying pressures economic and social, and unpredictable policies in any number of fields – the level of uncertainty about China in the year ahead has never been higher than in this fourth edition of our MERICS China Forecast. We solicited the views of 880 China experts and non-expert members of the public with an interest in the country. Our survey suggests the country’s course is most unpredictable – except that it will continue to stand by Moscow and accept EU-China relations fraying. The MERICS China Forecast 2023 has received funding from the European Union’s Horizon Europe research and innovation programme under grant agreement number 101061700. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union. Neither the European Union nor the granting authority can be held responsible for them.
Dark chiral symmetry breaking and the origin of the electroweak scale
Creators: name: Carone, Christopher D.
name: Ramos, Raymundo
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study a classically scale-invariant model in which strong dynamics in a dark sector sets the scale of electroweak symmetry breaking. Our model is distinct from others of this type that have appeared in the recent literature. We show that the Higgs sector of the model is phenomenologically viable and that the spectrum of dark sector states includes a partially composite dark matter candidate.
description: 15 pages LaTeX, two pdf figures, to appear in Phys. Lett. B