cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A new coumarin from stem bark of Calophyllum wallichianum
Creators: name: Tee, Keng Hong
name: Ee, Gwendoline Cheng Lian
name: Intan Safinar Ismail
name: Thiruventhan Karunakaran
name: Soek Sin Teh
name: Jong, Vivien Yi Mian
name: Siti Mariam Mohd Nor
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: A phytochemical study carried out on the plant, Calophyllum wallichianum has led to the isolation of a new coumarin, wallimarin T (1) and a known coumarin, calanolide E (2) along with two common triterpenes, friedelin (3) and stigmasterol (4). The structures of these compounds were elucidated with the aid of spectroscopic analyses such as FT-IR, GC-MS, and NMR. MIC assay against the Bacillus bacteria were conducted on the extracts and this gave MIC values ranging from 0.313 to 1.25 mg/mL. Compound 2 was weakly inhibitory towards the Bacilli strains with MIC values ranging from 0.25–0.50 mg/mL. Wallimarin T (1) was not active towards all four bacteria. Overall, the extracts exhibited weak bactericidal properties whereas compound 2 was not bactericidal on the tested bacteria. The hexane and chloroform extracts of the plant were found to be inhibitors to the growth of Bacillus megaterium, Bacillus cereus, Bacillus pumilus and Bacillus subtilis.
Brownian Thermal Noise in Functional Optical Surfaces
Creators: name: Kroker, S.
name: Dickmann, J.
name: Hurtado, C. B. Rojas
name: Heinert, D.
name: Nawrodt, R.
name: Levin, Y.
name: Vyatchanin, S. P.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We present a formalism to compute Brownian thermal noise in functional optical surfaces such as grating reflectors, photonic crystal slabs or complex metamaterials. Such computations are based on a specific readout variable, typically a surface integral of a dielectric interface displacement weighed by a form factor. This paper shows how to relate this form factor to Maxwell's stress tensor computed on all interfaces of the moving surface. As an example, we examine Brownian thermal noise in monolithic T-shape grating reflectors. The previous computations by Heinert et al. [Heinert et al., PRD 88 (2013)] utilizing a simplified readout form factor produced estimates of thermal noise that are tens of percent higher than those of the exact analysis in the present paper. The relation between the form factor and Maxwell's stress tensor implies a close correlation between the optical properties of functional optical surfaces and thermal noise.
description: 6 Figures, 7 pages
Optimizing novel penetration enhancing hybridized vesicles for augmenting the in-vivo effect of an anti-glaucoma drug
Creators: name: Naguib, Sarah S.
name: Hathout, Rania M.
name: Mansour, Samar
Publisher: name: Taylor & Francis
Year: 2017
Subjects: Space Science
Medicine
Pharmacology
Biotechnology
Biological Sciences not elsewhere classified

description: Usually the topical delivery of ocular drugs poses a great challenge. Accordingly, the work in this study comprised the use of different hybrids of generally regarded as safe (GRAS) oils and surfactants in order to develop and optimize novel acetazolamide (AZD) entrapped-vesicular systems aiming at improving its ocular delivery and reaching better therapeutic outcomes in the treatment of glaucoma. The phospholipid/cholesterol bilayer of the vesicles was enriched with hybrids of Tween 80, Labrasol, Transcutol and Labrafac lipophile WL in different masses and proportions according to a mixture design viz. D-optimal mixture design. Three models were generated comprising three responses: particles size, percentage of entrapment efficiency and amount of drug released after 24 hours (Q24h). The results demonstrated the ability of the penetration enhancing hybrids in modulating the three responses compared to the conventional liposomes. Transmission electron microscope was used to characterize the selected formulations. Sterilization of selected formulations was carried out using gamma radiation and the effect of gamma radiations on entrapment, particle size and in vitro release were studied. The selected sterilized formulations were tested in-vivo on the eyes of albino rabbits in order to evaluate the efficiency of the novel delivery systems on the intra-ocular pressure reduction (IOP) compared to drug solution and the conventional liposomes. The novel formulations proved their efficiency in reducing the IOP to lower values compared to the conventional liposomes, which pose new successful platform for ocular delivery of AZD and other anti-glaucoma drug analogs.
One new indolocarbazole alkaloid from the Streptomyces sp. A22
Creators: name: Xiangwei Cheng
name: Zhou, Biao
name: Huazhang Liu
name: Huo, Chao
name: Wanjing Ding
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Inorganic Chemistry

description: One new indolocarbazole alkaloid, 12-N-methyl-k252c, together with eight known indolocarbazoles were isolated from the rice solid fermentation of the marine-derived Streptomyces sp. A22. Their structures were elucidated on the basis of spectroscopic methods (UV, IR, HRESITOF MS, 1D NMR and 2D NMR). All of these compounds were evaluated for bromodomain-containing protein 4 (BRD4) inhibitory activities and cytotoxic activity assay, respectively. Compounds 4 and 5 showed moderate cytotoxic activity with an IC50 value of 3.52 and 3.93 μM, respectively. Additionally, compound 1 also was tested for enzyme inhibition activities of protein kinases and showed moderate activity with IC50 values of 0.91–1.84 μM.
Fear Relevance in Fear Generalization
Creators: name: Aslanidou, Asimina
name: Andreatta, Marta
name: Wieser, Matthias
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Psychiatry and Psychology
subject: Medicine and Health Sciences
subject: Mental and Social Health
subject: Social and Behavioral Sciences
subject: anxiety
subject: fear generalization
subject: fear-relevance
subject: SCR
subject: ssveps

description: This project is the registration of a study on fear-relevant stimuli on fear generalization before and partly during data collection
Axion-like particles and e-ASTROGAM
Creators: name: Roncadelli, Marco
name: Galanti, Giorgio
name: De Angelis, Alessandro
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: e-ASTROGAM is a space mission with unprecedented sensitivity to photons in the MeV range, proposed within the ESA M5 call. In this note we describe some measurements sensitive to axion-like particles, for which performance in the MeV/GeV range is of primary importance, and e-ASTROGAM could be the key for discovery. Keywords: Axions. ALPs. Dark-matter candidates. Gamma-ray astrophysics.
VEGF-mediated tight junctions pathological fenestration enhances doxorubicin-loaded glycolipid-like nanoparticles traversing BBB for glioblastoma-targeting therapy
Creators: name: Wen, Lijuan
name: Tan, Yanan
name: Dai, Suhuan
name: Zhu, Yun
name: Meng, Tingting
name: Yang, Xiqin
name: Liu, Yupeng
name: Liu, Xuan
name: Yuan, Hong
name: Hu, Fuqiang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: The existence of blood–brain barrier (BBB) greatly hindered the penetration and accumulation of chemotherapeutics into glioblastoma (GBM), accompany with poor therapeutic effects. The growth of GBM supervene the impairment of tight junctions (TJs); however, the pathogenesis of BBB breakdown in GBM is essentially poorly understood. This study found that vascular endothelial growth factor (VEGF) secreted by GBM cells plays an important role in increasing the permeability of BBB by disrupting endothelial tight junction proteins claudin-5 and thus gave doxorubicin (DOX)-loaded glycolipid-like nanoparticles (Ap-CSSA/DOX), an effective entrance to brain tumor region for GBM-targeting therapy. In addition, VEGF downregulates the expression of claudin-5 with a dose-dependent mode, and interfering with the VEGF/VEGFR pathway using its inhibitor axitinib could reduce the permeability of BBB and enhance the integrity of the barrier. Ap-CSSA/DOX nanoparticles showed high affinity to expressed low-density lipoprotein receptor-related proteins 1 (LRP1) in both BBB and GBM. And BBB pathological fenestration in GBM further exposed more LRP1 binding sites for Ap-CSSA/DOX nanoparticles targeting to brain tumor, resulting in a higher transmembrane transport ratio in vitro and a stronger brain tumor biodistribution in vivo, and finally realizing a considerable antitumor effect. Overall, taking advantage of BBB pathological features to design an appropriate nanodrug delivery system (NDDS) might provide new insights into other central nervous system (CNS) diseases treatment.
Gate tunable current partition in graphene based topological zero lines
Creators: name: Ren, Yafei
name: Wang, Ke
name: Deng, Xinzhou
name: Yang, Shengyuan A.
name: Jung, Jeil
name: Qiao, Zhenhua
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We demonstrate new mechanisms for gate tunable current partition at topological zero-line intersections in a graphene-based current splitter. Based on numerical calculations of the non-equilibrium Green's functions and Landauer-Büttiker formula, we show that the presence of a perpendicular magnetic field on the order of a few Teslas allows for carrier sign dependent current routing. In the zero-field limit the control on current routing and partition can be achieved within a range of $10\%$-$90\%$ of the total incoming current by tuning the carrier density at tilted intersections, or by modifying the relative magnitude of the bulk band gaps via gate voltage. We discuss the implications of our findings in the design of topological zero-line networks where finite orbital magnetic moments are expected when the current partition is asymmetric.
description: 14 pages, 4 figures
The Road to the Future of Healthcare: Transmitting Interoperable Healthcare Data Through a 5G Based Communication Platform
Creators: name: Mavrogiorgou, Argyro
name: Kiourtis, Athanasios
name: Touloupou, Marios
name: Kapassa, Evgenia
name: Kyriazis, Dimosthenis
Publisher: name: Zenodo
Year: 2019
Subjects: 5G network
Data integration
Data anonymization
Data cleaning
Data quality
Data interoperability
Healthcare

description: Current devices and sensors have revolutionized our daily lives, with the healthcare domain exploring and adapting new technologies. The rapid explosion of digital healthcare happened with the help of current 4G LTE technologies including innovations such as the continuous monitoring of patient vitals, teleporting doctors to a virtual environment or leveraging Artificial Intelligence to generate new medical insights. The arised problem is that current 4G LTE based communication platforms will not be able to keep up with the exploding connectivity demands. This is where the new 5G technology comes, expected to support ultra-reliable, low-latency and massive data communications. In this paper, an end-to-end approach is being provided in the healthcare domain for gathering medical data, anonymizing it, cleaning it, making it interoperable, and finally storing it through 5G network technologies, for their transmission to a different location, supporting real-time results and decision-making.
description: Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works
Dissipative stabilization of quantum-feedback-based multipartite entanglement with Rydberg atoms
Creators: name: Shao, X. Q.
name: WU, J. H.
name: Yi, X. X.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: A quantum-feedback-based scheme is proposed for generating multipartite entanglements of Rydberg atoms in a dissipative optical cavity. The Rydberg blockade mechanism efficiently prevents double excitations of the system, which is further exploited to speed up the stabilization of an entangled state with a single Rydberg state excitation. The corresponding feedback operations are greatly simplified, since only one regular atom needs to be controlled during the whole process, irrespective of the number of particles. The form of entangled state is also adjustable via regulating the Rabi frequencies of driving fields. Moreover, a relatively long-life time of the high-lying Rydberg level guarantees a high fidelity in a realistic situation.
title: ADCO, Cinquième cartulaire de Saint-Étienne de Dijon (1664), Cart. 28 (G 132), 258 folios, f. 00226
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Cinquième cartulaire de Saint-Étienne de Dijon (1664), Archives départementales de la Côte-d'Or, Cart. 28 (G 132), 258 folios, f. 00226, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cinquième cartulaire de Saint-Étienne de Dijon (1664), Archives départementales de la Côte-d'Or, Cart. 28 (G 132), 258 folios, f. 00226, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Additional file 5 of Hsa_circ_0005273 facilitates breast cancer tumorigenesis by regulating YAP1-hippo signaling pathway
Creators: name: Wang, Xuehui
name: Ji, Changle
name: Hu, Jiashu
name: Deng, Xiaochong
name: Zheng, Wenfang
name: Yu, Yunhe
name: Hua, Kaiyao
name: Zhou, Xiqian
name: Fang, Lin
Publisher: name: figshare
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Statistics
subject: FOS: Mathematics
subject: Hematology

description: Additional file 5 Table S4 The relationship between the expression of hsa_circ_0005273 and various clinicopathological variables of luminal-like cohort in BC patients.
Corrigendum for "Almost vanishing polynomials and an application to the Hough transform"
Creators: name: Torrente, Maria-Laura
name: Beltrametti, Mauro C.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 26C10, 15A60, 14Q10, 14H50

description: In this note we correct a technical error occurred in [M. Torrente and M.C. Beltrametti, "Almost vanishing polynomials and an application to the Hough transform", J. Algebra Appl. 13(8), (2014)]. This affects the bounds given in that paper, even though the structure and the logic of all proofs remain fully unchanged.
description: 30 pages
Additional file 1: of Theoretical System of Contact-Mode Triboelectric Nanogenerators for High Energy Conversion Efficiency
Creators: name: Chen, Huamin
name: Xu, Yun
name: Zhang, Jiushuang
name: Wu, Weitong
name: Song, Guofeng
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Space Science
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Virology

description: Note 1. Detailed calculation of the motion equations. Figure S1. Motion curves of the top plate in the (a) separation process and (b) contact process. Note 2. Detailed calculation of the output performance. Figure S2. (a) The relationship of maximum output voltage and current with the load resistance. (b) The relationship of instantaneous power with the load resistance. Note 3. Detailed calculation of the motion equations and output performance including the spring system. (DOCX 3925Â kb)
Facebook 2020 Election Research Project: Effects of Algorithmic Ranking and Virality
Creators: name: Barbera, Pablo
name: Wynter, Thomas
name: Velasco, Carlos
name: Franco, Annie
name: Iyengar, Shanto
name: Wojcieszak, Magdalena
name: Stroud, Talia
name: Devra Moehler
name: Pan, Jennifer
name: Lazer, David
name: Tromble, Rebekah
name: Tucker, Joshua A.
name: Gonzalez-Bailon, Sandra
name: Nyhan, Brendan J.
name: Guess, Andrew
name: Deen Freelon
name: Winter Mason
name: De Jonge, Chad Kiewiet
name: Hunt Allcott
name: Gentzkow, Matthew
name: Settle, Jaime
name: Tenorio, Adriana Crespo
name: Malhotra, Neil
name: Kim, Young Mie
name: Thorson, Emily
name: Wilkins, Arjun
name: Persily, Nate
Publisher: name: Open Science Framework
Year: 2024
Subjects: subject: Social and Behavioral Sciences

description: Pre-analysis plans for the Facebook 2020 Election Research Project. The results from the studies outlined in this PAP will be published in two papers forthcoming in Science, July 28, 2023.
Bosonic symmetries of the extended fermionic $(2N,2M)$-Toda hierarchy
Creators: name: Li, Chuanzhong
Publisher: name: arXiv
Year: 2017
Subjects: subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: Operator Algebras (math.OA)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: In this paper, we construct the additional symmetries of the fermionic $(2N,2M)$-Toda hierarchy basing on the generalization of the $N{=}(1|1)$ supersymmetric two dimensional Toda lattice hierarchy. These additional flows constitute a $w_{\infty}\times w_{\infty}$ Lie algebra. As a Bosonic reduction of the $N{=}(1|1)$ supersymmetric two dimensional Toda lattice hierarchy and the fermionic $(2N,2M)$-Toda hierarchy, we define a new extended fermionic $(2N,2M)$-Toda hierarchy which admits a Bosonic Block type superconformal structure.
description: 17 pages
Polydopamine and peptide decorated doxorubicin-loaded mesoporous silica nanoparticles as a targeted drug delivery system for bladder cancer therapy
Creators: name: Wei, Yi
name: Gao, Li
name: Wang, Lu
name: Shi, Lin
name: Wei, Erdong
name: Zhou, Baotong
name: Zhou, Li
name: Ge, Bo
Publisher: name: Taylor & Francis
Year: 2017
Subjects: Biochemistry
Space Science
Medicine
Cell Biology
Molecular Biology
Pharmacology
Biotechnology
Cancer

description: We reported a simple polydopamine (PDA)-based surface modification method to prepare novel targeted doxorubicin-loaded mesoporous silica nanoparticles and peptide CSNRDARRC conjugation (DOX-loaded MSNs@PDA-PEP) for enhancing the therapeutic effects on bladder cancer. Drug-loaded NPs were characterized in terms of size, size distribution, zeta potential, transmission electron microscopy (TEM), Brunauer–Emmett–Teller (BET) surface area and drug loading content. In vitro drug release indicated that DOX-loaded MSNs@PDA and MSNs@PDA-PEP had similar release kinetic profiles of DOX. The PDA coating well controlled DOX release and was highly sensitive to pH value. Confocal laser scanning microscopy (CLSM) showed that drug-loaded MSNs could be internalized by human bladder cancer cell line HT-1376, and DOX-loaded MSNs@PDA-PEP had the highest cellular uptake efficiency due to ligand–receptor recognition. The antitumor effects of DOX-loaded nanoparticles were evaluated by the MTT assay in vitro and by a xenograft tumor model in vivo, demonstrating that targeted nanocarriers DOX-loaded MSNs@PDA-PEP were significantly superior to free DOX and DOX-loaded MSNs@PDA. The novel DOX-loaded MSNs@PDA-PEP, which specifically recognized HT-1376 cells, can be used as a potential targeted drug delivery system for bladder cancer therapy.
Oil palm age estimation using broad-band and narrow-band vegetation indices derived from Sentinel-2 data
Creators: name: Shafri, Helmi Z. M.
Publisher: name: Asia-Pacific Journal of Science and Technology
Year: 2024
Subjects: Oil palm age
Remote sensing
Vegetation indices
Spatial distribution map

description: Asia-Pacific Journal of Science and Technology, 29, 2, 13 (9 pages)
Long-range interactions in the effective low energy Hamiltonian of Sr2IrO4: a core level resonant inelastic x-ray scattering study
Creators: name: Agrestini, S.
name: Kuo, C. -Y.
name: Sala, M. Moretti
name: Hu, Z.
name: Kasinathan, D.
name: Ko, K. -T.
name: Glatzel, P.
name: Rossi, M.
name: Cafun, J. -D.
name: Kvashnina, K. O.
name: Matsumoto, A.
name: Takayama, T.
name: Takagi, H.
name: Tjeng, L. H.
name: Haverkort, M. W.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We have investigated the electronic structure of Sr2IrO4 using core level resonant inelastic x-ray scattering. The experimental spectra can be well reproduced using ab initio density functional theory based multiplet ligand field theory calculations, thereby validating these calculations. We found that the low-energy, effective Ir t2g orbitals are practically degenerate in energy. We uncovered that covalency in Sr2IrO4, and generally in iridates, is very large with substantial oxygen ligand hole character in the Ir t2g Wannier orbitals. This has far reaching consequences, as not only the onsite crystal-field energies are determined by the long range crystal-structure, but, more significantly, magnetic exchange interactions will have long range distance dependent anisotropies in the spin direction. These findings set constraints and show pathways for the design of d^5 materials that can host compass-like magnetic interactions.
Cell-penetrating peptide conjugates to enhance the antitumor effect of paclitaxel on drug-resistant lung cancer
Creators: name: Duan, Ziqing
name: Chen, Cuitian
name: Qin, Jing
name: Liu, Qi
name: Wang, Qi
name: Xu, Xinchun
name: Wang, Jianxin
Publisher: name: Taylor & Francis
Year: 2017
Subjects: Biophysics
Biochemistry
Space Science
Cell Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Hematology
Virology

description: To conquer the drug resistance of tumors and the poor solubility of paclitaxel (PTX), two PTX-cell-penetrating peptide conjugates (PTX-CPPs), PTX-TAT and PTX-LMWP, were synthesized and evaluated for the first time. Compared with free PTX, PTX-CPPs displayed significantly enhanced cellular uptake, elevated cell toxicity, increased cell apoptosis, and decreased mitochondrial membrane potential (Δψm) in both A549 and A549T cells. PTX-LMWP exhibited a stronger inhibitory effect than PTX-TAT in A549T cells. Analysis of cell-cycle distribution showed that PTX-LMWP influenced mitosis in drug-resistant A549T tumor cells via a different mechanism than PTX. PTX-CPPs were more efficient in inhibiting tumor growth in tumor-bearing mice than free PTX, which suggested their better in vivo antitumor efficacy. Hence, this study demonstrates that PTX-CPPs, particularly PTX-LMWP, have outstanding potential for inhibiting the growth of tumors and are a promising approach for treating lung cancer, especially drug-resistant lung cancer.
Additional file 6 of Hsa_circ_0005273 facilitates breast cancer tumorigenesis by regulating YAP1-hippo signaling pathway
Creators: name: Wang, Xuehui
name: Ji, Changle
name: Hu, Jiashu
name: Deng, Xiaochong
name: Zheng, Wenfang
name: Yu, Yunhe
name: Hua, Kaiyao
name: Zhou, Xiqian
name: Fang, Lin
Publisher: name: figshare
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Statistics
subject: FOS: Mathematics
subject: Hematology

description: Additional file 6. Original western blotting images in this study.
Efectos de Temperatura Finita y Curvatura en QCD y Modelos de Quarks Quirales
Creators: name: Megias, Eugenio
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Theory (hep-th)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We develop the heat kernel method in the context of finite temperature quantum field theory. We compute the heat kernel expansion in the presence of general gauge and scalar fields which may be non Abelian and non stationary. The Polyakov loop appears at finite temperature as a new gauge covariant operator. We apply this method in the computation of the fully gauge invariant effective action of QCD in the regime of high temperature. It is obtained the dimensionally reduced effective action of QCD as well. In the context of chiral quark models, in particular the Nambu--Jona-Lasinio and the spectral quark model, we apply this method to compute the low-energy chiral Lagrangian at finite temperature. The coupling of the Polyakov loop with these models allows to solve some inconsistencies appearing in the standard treatment at finite temperature: generation of multi-quark states, large $N_c$ counting, etc. On the other hand, we show that recent available lattice data for the renormalized Polyakov loop above the deconfinement phase transition exhibit unequivocal inverse power temperature corrections driven by a dimension 2 gluon condensate. This simple ansatz provides a good overall description of the data throughout the deconfinement phase until near the critical temperature with just two parameters. Finally, we study several chiral quark models in the light of chiral perturbation theory in curved space-time. The low energy structure of the energy momentum tensor in these models with SU(3) flavor symmetry is analyzed in the presence of external gravitational fields.
description: PhD thesis (University of Granada, Spain), April 2006. 198 pages. In Spanish
Additional Methods, Data Figures, Tables, Sound files description and Matlab codes from Imitation of novel conspecific and human speech sounds in the killer whale (Orcinus orca)
Creators: name: Abramson, José Z.
name: Mª Victoria Hernández-Lloreda
name: García, Lino
name: Colmenares, Fernando
name: Aboitiz, Francisco
name: Call, Josep
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 170299 Cognitive Science not elsewhere classified
subject: FOS: Psychology
subject: 60801 Animal Behaviour
subject: FOS: Biological sciences

description: ESM Manuscript RSPB­2017­2171. Z. Abramson et al. Imitation of novel sounds in the killer whale.
Sustained-release solid dispersion of pelubiprofen using the blended mixture of aminoclay and pH independent polymers: preparation and in vitro/in vivo characterization
Creators: name: Lee, Yeo-Song
name: Song, Jae Guen
name: Lee, Sang Hoon
name: Han, Hyo-Kyung
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Computational Biology

description: The present study aimed to develop the sustained-release oral dosage form of pelubiprofen (PEL) by using the blended mixture of 3-aminopropyl functionalized-magnesium phyllosilicate (aminoclay) and pH-independent polymers. The sustained-release solid dispersion (SRSD) was prepared by the solvent evaporation method and the optimal composition of SRSD was determined as the weight ratio of drug: Eudragit® RL PO: Eudragit® RS PO of 1:1:2 in the presence of 1% of aminoclay (SRSD(F6)). The dissolution profiles of SRSD(F6) were examined at different pHs and in the simulated intestinal fluids. The drug release from SRSD(F6) was limited at pH 1.2 and gradually increased at pH 6.8, resulting in the best fit to Higuchi equation. The sustained drug release from SRSD(F6) was also maintained in simulated intestinal fluid at fasted-state (FaSSIF) and fed-state (FeSSIF). The structural characteristics of SRSD(F6) were examined by using powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FT-IR), indicating the change of drug crystallinity to an amorphous form. After oral administration in rats, SRSD(F6) exhibited the prolonged drug exposure in plasma. For both PEL and PEL-transOH (active metabolite), once a day dosing of SRSD(F6) achieved oral exposure (AUC) comparable to those from the multiple dosing (3 times a day) of untreated drug. In addition, the in vivo absorption of SRSD(F6) was well-correlated with the in vitro dissolution data, establishing a good level A in vitro/in vivo correlation. These results suggest that SRSD(F6) should be promising for the sustained-release of PEL, thereby reducing the dosing frequency.
Effect of the fabrication parameters of MWCNTs/α-MnO2 nanocomposite through the Taguchi technique
Creators: name: Pranjal Sarmah
Publisher: name: Asia-Pacific Journal of Science and Technology
Year: 2024
Subjects: Manganese dioxide
Multi-walled carbon nanotubes
Nanocomposite
Powder metallurgy
Taguchi method

description: Asia-Pacific Journal of Science and Technology, 29, 2, 14 (11 pages)
Vanishing of $L^{2}$-Betti numbers and failure of acylindrical hyperbolicity of matrix groups over rings
Creators: name: Ji, Feng
name: Ye, Shengkui
Publisher: name: arXiv
Year: 2017
Subjects: subject: Algebraic Topology (math.AT)
subject: Group Theory (math.GR)
subject: Geometric Topology (math.GT)
subject: FOS: Mathematics

description: Let $R$ be an infinite commutative ring with identity and $n\geq 2$ be an integer. We prove that for each integer $i=0,1,\cdots ,n-2,$ the $L^{2}$-Betti number $b_{i}^{(2)}(G)=0,$ $\ $when $G=\mathrm{GL}_{n}(R)$ the general linear group, $\mathrm{SL}_{n}(R)$ the special linear group, $% E_{n}(R)$ the group generated by elementary matrices. When $R$ is an infinite principal ideal domain, similar results are obtained for $\mathrm{Sp}_{2n}(R)$ the symplectic group, $\mathrm{ESp}_{2n}(R)$ the elementary symplectic group, $\mathrm{O}(n,n)(R)$ the split orthogonal group or $\mathrm{EO}(n,n)(R)$ the elementary orthogonal group. Furthermore, we prove that $G$ is not acylindrically hyperbolic if $n\geq 4$. We also prove similar results for a class of noncommutative rings. The proofs are based on a notion of $n$-rigid rings.
description: 17 pages, to appear in Algebraic & Geometric Topology
Temperature-sensitive heparin-modified poloxamer hydrogel with affinity to KGF facilitate the morphologic and functional recovery of the injured rat uterus
Creators: name: Xu, He-Lin
name: Xu, Jie
name: Zhang, Si-Si
name: Zhu, Qun-Yan
name: Jin, Bing-Hui
name: ZhuGe, De-Li
name: Shen, Bi-Xin
name: Wu, Xue-Qing
name: Xiao, Jian
name: Zhao, Ying-Zheng
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Endometrial injury usually results in intrauterine adhesion (IUA), which is an important cause of infertility and recurrent miscarriage in reproductive women. There is still lack of an effective therapeutic strategy to prevent occurrence of IUA. Keratinocyte growth factor (KGF) is a potent repair factor for epithelial tissues. Here, a temperature-sensitive heparin-modified poloxamer (HP) hydrogel with affinity to KGF (KGF-HP) was used as a support matrix to prevent IUA and deliver KGF. The rheology of KGF-HP hydrogel was carefully characterized. The cold KGF-HP solution was rapidly transited to hydrogel with suitable storage modulus (G′) and loss modulus (G″) for the applications of uterus cavity at temperature of 33 °C. In vitro release demonstrated that KGF was released from HP hydrogels in sustained release manner for a long time. In vivo bioluminescence imaging showed that KGF-HP hydrogel was able to prolong the retention of the encapsulated KGF in injured uterus of rat model. Moreover, the morphology and function of the injured uterus were significantly recovered after administration of KGF-HP hydrogel, which were evaluated by two-dimensional ultrasound imaging and receptive fertility. Not only proliferation of endometrial glandular epithelial cells and luminal epithelial cells but also angiogenesis of injured uterus were observed by Ki67 and CD31 staining after 7 d of treatment with KGF-HP hydrogel. Finally, a close relatively relationship between autophagy and proliferation of endometrial epithelial cells (EEC) and angiogenesis was firstly confirmed by detecting expression of LC3-II and P62 after KGF treatment. Overall, KGF-HP may be used as a promising candidate for IUA treatment.
Single synchronous delivery of FK506-loaded polymeric microspheres with pancreatic islets for the successful treatment of streptozocin-induced diabetes in mice
Creators: name: Pathak, Shiva
name: Regmi, Shobha
name: Gupta, Biki
name: Poudel, Bijay K.
name: Pham, Tung Thanh
name: Yong, Chul Soon
name: Kim, Jong Oh
name: Kim, Jae-Ryong
name: Park, Min Hui
name: Bae, Young Kyung
name: Yook, Simmyung
name: Ahn, Cheol-Hee
name: Jeong, Jee-Heon
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Marine Biology

description: Immune rejection after transplantation is common, which leads to prompt failure of the graft. Therefore, to prolong the survival time of the graft, immunosuppressive therapy is the norm. Here, we report a robust immune protection protocol using FK506-loaded microspheres (FK506M) in injectable hydrogel. Pancreatic islets were codelivered with the FK506M into the subcutaneous space of streptozocin-induced diabetic mice. The islets codelivered with 10 mg/kg FK506M maintained normal blood glucose levels during the study period (survival rate: 60%). However, transplantation of islets and FK506M at different sites hardly controlled the blood glucose level (survival rate: 20%). Immunohistochemical analysis revealed an intact morphology of the islets transplanted with FK506M. In addition, minimal number of immune cells invaded inside the gel of the islet-FK506M group. The single injection of FK506M into the local microenvironment effectively inhibited immune rejection and prolonged the survival time of transplanted islets in a xenograft model.
Higher-order modes of vacuum-clad ultrathin optical fibers
Creators: name: Kien, Fam Le
name: Busch, Thomas
name: Truong, Viet Giang
name: Chormaic, Sile Nic
Publisher: name: arXiv
Year: 2017
Subjects: subject: Optics (physics.optics)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present a systematic treatment of higher-order modes of vacuum-clad ultrathin optical fibers. We show that, for a given fiber, the higher-order modes have larger penetration lengths, larger effective mode radii, and larger fractional powers outside the fiber than the fundamental mode. We calculate, both analytically and numerically, the Poynting vector, propagating power, energy, angular momentum, and helicity (or chirality) of the guided light. The axial and azimuthal components of the Poynting vector can be negative with respect to the direction of propagation and the direction of phase circulation, respectively, depending on the position, the mode type, and the fiber parameters. The orbital and spin parts of the Poynting vector may also have opposite signs in some regions of space. We show that the angular momentum per photon decreases with increasing fiber radius and increases with increasing azimuthal mode order. The orbital part of angular momentum of guided light depends not only on the phase gradient but also on the field polarization, and is positive with respect to the direction of the phase circulation axis. Meanwhile, depending on the mode type, the spin and surface parts of angular momentum and the helicity of the field can be negative with respect to the direction of the phase circulation axis.
description: 24 pages, 22 figures
Ichthyochory in a temperate river system by common carp (Cyprinus carpio)
Creators: name: VonBank, Jay A.
name: DeBoer, Jason A.
name: Casper, Andrew F.
name: Hagy, Heath M.
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Molecular Biology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 60506 Virology

description: Some fish are important dispersal vectors of aquatic plants (i.e., ichthyochory), yet few examples have been documented outside of the Neotropics. Although highly modified and degraded, the upper Illinois River Waterway supports common carp (Cyprinus carpio) populations and abundant aquatic vegetation. As common carp have been previously documented to consume aquatic vegetation seeds, we assessed diets to determine the potential for common carp to function as dispersal vectors for aquatic vegetation seeds that may be important for restoration of rivers and floodplain wetlands. Whole seeds occurred at a high frequency and 42 seed taxa were discovered in the digestive system of common carp. Electivity analysis indicated that most seeds present were incidentally ingested; however, common carp diets contained seeds of wild celery (Vallisneria americana) at rates greater than expected by random chance. Our study indicates common carp may fill a similar functional role of seed dispersal for aquatic plant communities in temperate large river systems as they do for fruiting plants in the Neotropics. Our results highlight an understudied aspect of temperate freshwater ecology – fish as a potential influence on plant dynamics and resources in rivers. Fish-mediated seed dispersal has important but poorly understood implications and should be further explored.
Reiserer_et_al_Appendix_Figure_ESM.pdf from Seed ingestion and germination in rattlesnakes: overlooked agents of rescue and secondary dispersal
Creators: name: Reiserer, Randall S.
name: Schuett, Gordon W.
name: Greene, Harry W.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology

description: Appendix of specimens examined and Figure showing kangaroo rat with seed-stuffed cheek pouches.
Anti-urolithiasis potential of Aerva lanata metabolites investigated in synthetic urine and cell-free in vitro assays
Creators: name: Thangammal, Anju
Publisher: name: Asia-Pacific Journal of Science and Technology
Year: 2024
Subjects: Anti-urolithiatic activity
Ayurveda
Calcium oxalate
Gas chromatography-mass Spectrometry
Kidney stones
Siddha medicine

description: Asia-Pacific Journal of Science and Technology, 29, 2, 15 (11 pages)
XRD patterns;BET isotherms;TEM images;TEM images;SEM images from MnO2-graphene nanosheets wrapped mesoporous carbon/sulfur composite for lithium-sulfur batteries
Creators: name: Zhengzheng Li
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 30399 Macromolecular and Materials Chemistry not elsewhere classified
subject: FOS: Chemical sciences

description: Fig. S1 XRD patterns of as-synthesized of Al-MIL-101-NH2.;Fig. S2 BET nitrogen adsorption-desorption isotherms of MC.;Fig. S3 a, b) TEM images of the MnO2 nanosheets.;Fig. S4 TEM images of the fabrication of MGN@MC/S.;Fig. S5 SEM images of the fabrication of MGN@MC/S.
title: ADCO, Sixième cartulaire de Saint-Étienne de Dijon (1662), Cart. 30 (G 133), 441 folios, f. 252
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire

description: Sixième cartulaire de Saint-Étienne de Dijon (1662), Archives départementales de la Côte-d'Or, Cart. 30 (G 133), 441 folios, f. 252, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Sixième cartulaire de Saint-Étienne de Dijon (1662), Archives départementales de la Côte-d'Or, Cart. 30 (G 133), 441 folios, f. 252, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Additional file 1 of C/EBPα regulates the fate of bone marrow mesenchymal stem cells and steroid-induced avascular necrosis of the femoral head by targeting the PPARγ signalling pathway
Creators: name: Duan, Ping
name: Wang, Hanyu
name: Yi, Xinzeyu
name: Zhang, Hao
name: Chen, Hui
name: Pan, Zhenyu
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1. Supplementary Data 1-5.
Supplementary material from Identification of allosteric disulfides from labile bonds in X-ray structures
Creators: name: Aster E. Pijning
name: Chiu, Joyce
name: Reichelle X. Yeo
name: Wong, Jason W. H.
name: Hogg, Philip J.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Biochemistry
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences

description: Table S3, Figures S1-S3
Identification of antimicrobial resistance in Salmonella enterica isolates from swine slaughterhouses in the Philippines through different antimicrobial susceptibility test protocols
Creators: name: Rivera, Windell L.
Publisher: name: Asia-Pacific Journal of Science and Technology
Year: 2024
Subjects: Antibiotic resistance genes
Antimicrobial resistance
Disk diffusion assay
Multidrug resistance
Polymerase chain reaction
Salmonella enterica

description: Asia-Pacific Journal of Science and Technology, 29, 2, 16 (9 pages)
Using Perturbed Underdamped Langevin Dynamics to Efficiently Sample from Probability Distributions
Creators: name: Duncan, A. B.
name: Nuesken, N.
name: Pavliotis, G. A.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Probability (math.PR)
subject: Mathematical Physics (math-ph)
subject: Numerical Analysis (math.NA)
subject: Statistics Theory (math.ST)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: In this paper we introduce and analyse Langevin samplers that consist of perturbations of the standard underdamped Langevin dynamics. The perturbed dynamics is such that its invariant measure is the same as that of the unperturbed dynamics. We show that appropriate choices of the perturbations can lead to samplers that have improved properties, at least in terms of reducing the asymptotic variance. We present a detailed analysis of the new Langevin sampler for Gaussian target distributions. Our theoretical results are supported by numerical experiments with non-Gaussian target measures.
description: 45 pages, 4 figures
Size Distribution ;Quorum Quenching Assays from Photophysical studies on curcumin-sophorolipid nanostructures: applications in quorum quenching and imaging
Creators: name: Sahana Vasudevan
name: Asmita A. Prabhune
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 90301 Biomaterials
subject: FOS: Medical engineering

description: Zeta Potential (-38.41mV) and DLS (100nm, polydispersity index: 0.27) of CUASL (5w/v %);Bioluminescence reduction by CUASL (5w/v %)
Mach-Zehnder interferometry using spin- and valley-polarized quantum Hall edge states in graphene
Creators: name: Wei, Di S.
name: van der Sar, Toeno
name: Sanchez-Yamagishi, Javier D.
name: Watanabe, Kenji
name: Taniguchi, Takashi
name: Jarillo-Herrero, Pablo
name: Halperin, Bertrand I.
name: Yacoby, Amir
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Confined to a two-dimensional plane, electrons in a strong magnetic field travel along the edge in one-dimensional quantum Hall channels that are protected against backscattering. These channels can be used as solid-state analogues of monochromatic beams of light, providing a unique platform for studying electron interference. Electron interferometry is regarded as one of the most promising routes for studying fractional and non-Abelian statistics and quantum entanglement via two-particle interference. However, creating an edge-channel interferometer in which electron-electron interactions play an important role requires a clean system and long phase coherence lengths. Here we realize electronic Mach-Zehnder interferometers with record visibilities of up to 98% using spin- and valley-polarized edge channels that co-propagate along a PN junction in graphene. We find that inter-channel scattering between same-spin edge channels along the physical graphene edge can be used to form beamsplitters, while the absence of inter-channel scattering along gate-defined interfaces can be used to form isolated interferometer arms. Surprisingly, our interferometer is robust to dephasing effects at energies an order of magnitude larger than observed in pioneering experiments on GaAs/AlGaAs quantum wells. Our results shed light on the nature of edge-channel equilibration and open up new possibilities for studying exotic electron statistics and quantum phenomena.
description: 18 pages, 11 figures
Small cities face greater impact from automation: Supplementary Material
Creators: name: Frank, Morgan R.
name: Lijun Sun
name: Cebrian, Manuel
name: Hyejin Youn
name: Rahwan, Iyad
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 60114 Systems Biology
subject: FOS: Biological sciences

description: Supplementary Material