cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 5 of Genetic toggle switch controlled by bacterial growth rate
Creators: name: Jaruszewicz-BĹOĹSka, Joanna
name: Lipniacki, Tomasz
Publisher: name: figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology

description: Figure S5. Stationary distributions of protein level based on stochastic simulations for different doubling times and different repression levels. (PDF 59 kb)
АТОПИЧЕСКИЙ ДЕРМАТИТ И БРОНХИАЛЬНАЯ АСТМА У ДЕТЕЙ: РОЛЬ НЕЙРОВЕРТЕБРАЛЬНЫХ И ГЕМОКОАГУЛЯЦИОННЫХ НАРУШЕНИЙ В ПАТОГЕНЕЗЕ ЗАБОЛЕВАНИЙ
Creators: name: ТОРОПОВА Н.П.
name: СОРОКИНА К.Н.
Publisher: name: Аллергология и Иммунология в Педиатрии
Year: 2011

description: The aim of the article is to study «intrinsic» mechanisms in pathogenesis of atopic dermatitis in children including a combination of atopic dermatitis with bronchial asthma and allergic rhinitis. The authors have defined a deviation in haemostatis and neuro-vertebral dysfunctions according to observation of the 2 groups of patients getting an in-patient treatment. The article presents the addition for widening of the therapy’s algorithm taking into account the revealed dysfunctions.
ДИНАМИКА ПОКАЗАТЕЛЕЙ МУКОЗАЛЬНОГО ИММУНИТЕТА, ЦИТОБАКТЕРИОЛОГИЧЕСКОГО И МОРФОФУНКЦИОНАЛЬНОГО СОСТОЯНИЯ СЛИЗИСТОЙ РОТОГЛОТКИ У ЧАСТО БОЛЕЮЩИХ ШКОЛЬНИКОВ ПОД ВЛИЯНИЕМ ГАЛОТЕРАПИИ (ЧАСТЬ 1)
Creators: name: ХАН М.А.
name: ЧЕРВИНСКАЯ А.В.
name: МИКИТЧЕНКО Н.А.
Publisher: name: Аллергология и Иммунология в Педиатрии
Year: 2011

description: The aim of this study was to assess the influence of halotherapy on mucosal immunity, cytobacteriological and morphofunctional state of oropharyngeal mucous membrane among children with acute respiratory disease (ARD). The study population comprised children with ARD symptoms received course of halotherapy and children without initially ARD symptoms received phylactic halotreatment. Children in the control group did not receive any halo-spray impact. The study have elicit the favorable effect of halotherapy, characterized by normalization of secretory IgA titers, improvement of morphofunctional state and protective function of oropharyngeal mucous membrane. On a base of the study differentiate models of halotherapy, according to a child initial health status, were constructed.
Live-Cell Imaging Quantifies Changes in Function and Metabolic NADH Autofluorescence During Macrophage-Mediated Phagocytosis of Tumor Cells
Creators: name: Bess, Shelby N.
name: Igoe, Matthew J.
name: Muldoon, Timothy J.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Space Science
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: The immune system has evolved to detect foreign antigens and deliver coordinated responses, while minimizing “friendly fire.” Until recently, studies investigating the behavior of immune cells were limited to static in vitro measurements. Although static measurements allow for real-time imaging, results are often difficult to translate to an in vivo setting. Multiphoton microscopy is an emerging method to capture spatial information on subcellular events and characterize the local microenvironment. Previous studies have shown that multiphoton microscopy can monitor changes in single-cell macrophage heterogeneity during differentiation. Therefore, there is a need to use multiphoton microscopy to monitor molecular interactions during immunological activities like phagocytosis. Here we investigate the correlation between phagocytic function and changes in endogenous optical reporters during phagocytosis. In vitro autofluorescence imaging of nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD) was used to detect metabolic changes in macrophages during phagocytosis. More specifically, optical redox ratio, mean NADH fluorescence lifetime and ratio of free to protein-bound NADH were used to quantify changes in metabolism. Results show that IFN-γ (M1) macrophages showed decreased optical redox ratios and mean NADH lifetime while phagocytosing immunogenic cancer cells compared to metastatic cells. To validate phagocytic function, a fluorescence microscopy-based protocol using a pH-sensitive fluorescent probe was used. Results indicate that M0 and M1 macrophages show similar trends in phagocytic potential. Overall, this work demonstrates that in vitro multiphoton imaging can be used to longitudinally track changes in phagocytosis and endogenous metabolic cofactors.
Additional file 1: of The sleep and circadian modulation of neural reward pathways: a protocol for a pair of systematic reviews
Creators: name: Byrne, Jamie
name: Murray, Greg
Publisher: name: figshare
Year: 2017
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: PRISMA-P (Preferred Reporting Items for Systematic review and Meta-Analysis Protocols) 2015 checklist: recommended items to address in a systematic review protocol*. (DOC 60 kb)
Scaling of Relativistic Shear Flows with Bulk Lorentz Factor
Creators: name: Liang, Edison
name: Fu, Wen
name: Boettcher, Markus
name: Roustazadeh, Parisa
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We compare Particle-in-Cell simulation results of relativistic electron-ion shear flows with different bulk Lorentz factors, and discuss their implications for spine-sheath models of blazar versus gamma-ray burst (GRB) jets. Specifically, we find that most properties of the shear boundary layer scale with the bulk Lorentz factor: the lower the Lorentz factor, the thinner the boundary layer, and the weaker the self-generated fields. Similarly, the energized electron spectrum peaks at an energy near the ion drift energy, which increases with bulk Lorentz factor, and the beaming of the accelerated electrons gets narrower with increasing Lorentz factor. This predicts a strong correlation between emitted photon energy, angular beaming and temporal variability with the bulk Lorentz factor. Observationally, we expect systematic differences between the high-energy emissions of blazars and GRB jets.
description: 27 pages, 8 figures, to be submitted
A Survey on Hypergraph Products (Erratum)
Creators: name: Hellmuth, Marc
name: Ostermeier, Lydia
name: Stadler, Peter F.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Discrete Mathematics (cs.DM)
subject: FOS: Computer and information sciences

description: A surprising diversity of different products of hypergraphs have been discussed in the literature. Most of the hypergraph products can be viewed as generalizations of one of the four standard graph products. The most widely studied variant, the so-called square product, does not have this property, however. Here we survey the literature on hypergraph products with an emphasis on comparing the alternative generalizations of graph products and the relationships among them. In this context the so-called 2-sections and L2-sections are considered. These constructions are closely linked to related colored graph structures that seem to be a useful tool for the prime factor decompositions w.r.t.\ specific hypergraph products. We summarize the current knowledge on the propagation of hypergraph invariants under the different hypergraph multiplications. While the overwhelming majority of the material concerns finite (undirected) hypergraphs, the survey also covers a summary of the few results on products of infinite and directed hypergraphs.
Trapping LLM Hallucinations Using Tagged Context Prompts
Creators: name: Feldman, Philip
name: Foulds, James
name: Pan, Shimei
Publisher: name: Maryland Shared Open Access Repository
Year: 2023

description: Recent advances in large language models (LLMs), such as ChatGPT, have led to highly sophisticated conversation agents. However, these models suffer from "hallucinations," where the model generates false or fabricated information. Addressing this challenge is crucial, particularly with AI-driven platforms being adopted across various sectors. In this paper, we propose a novel method to recognize and flag instances when LLMs perform outside their domain knowledge, and ensuring users receive accurate information. We find that the use of context combined with embedded tags can successfully combat hallucinations within generative language models. To do this, we baseline hallucination frequency in no-context prompt-response pairs using generated URLs as easily-tested indicators of fabricated data. We observed a significant reduction in overall hallucination when context was supplied along with question prompts for tested generative engines. Lastly, we evaluated how placing tags within contexts impacted model responses and were able to eliminate hallucinations in responses with 98.88% effectiveness.
Additional file 1: of Cost analysis of two community-based HIV testing service modalities led by a Non-Governmental Organization in Cape Town, South Africa
Creators: name: Sue-Ann Meehan
name: Nulda Beyers
name: Ronelle Burger
Publisher: name: figshare
Year: 2017
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: Plant Biology

description: Categories of core and support personnel included in the study. (PDF 16Â kb)
Machine Learning and LHC Event Generation
Creators: name: Butter, Anja
name: Plehn, Tilman
name: Schumann, Steffen
name: Badger, Simon
name: Caron, Sascha
name: Cranmer, Kyle
name: Di Bello, Francesco Armando
name: Dreyer, Etienne
name: Forte, Stefano
name: Ganguly, Sanmay
name: Gonçalves, Dorival
name: Gross, Eilam
name: Heimel, Theo
name: Heinrich, Gudrun
name: Heinrich, Lukas
name: Held, Alexander
name: Höche, Stefan
name: Howard, Jessica N.
name: Ilten, Philip
name: Isaacson, Joshua
name: Janßen, Timo
name: Jones, Stephen
name: Kado, Marumi
name: Kagan, Michael
name: Kasieczka, Gregor
name: Kling, Felix
name: Kraml, Sabine
name: Krause, Claudius
name: Krauss, Frank
name: Kröninger, Kevin
name: Barman, Rahool Kumar
name: Luchmann, Michel
name: Magerya, Vitaly
name: Maitre, Daniel
name: Malaescu, Bogdan
name: Maltoni, Fabio
name: Martini, Till
name: Mattelaer, Olivier
name: Nachman, Benjamin
name: Pitz, Sebastian
name: Rojo, Juan
name: Schwartz, Matthew
name: Shih, David
name: Siegert, Frank
name: Stegeman, Roy
name: Stienen, Bob
name: Thaler, Jesse
name: Verheyen, Rob
name: Whiteson, Daniel
name: Winterhalder, Ramon
name: Zupan, Jure
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2022
Subjects: interface
CERN LHC Coll

description: First-principle simulations are at the heart of the high-energy physics research program. They link the vast data output of multi-purpose detectors with fundamental theory predictions and interpretation. This review illustrates a wide range of applications of modern machine learning to event generation and simulation-based inference, including conceptional developments driven by the specific requirements of particle physics. New ideas and tools developed at the interface of particle physics and machine learning will improve the speed and precision of forward simulations, handle the complexity of collision data, and enhance inference as an inverse simulation problem.
Reassessment of the Null Result of the HST Search for Planets in 47 Tucanae
Creators: name: Masuda, Kento
name: Winn, Joshua N.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We revisit the null result of the Hubble Space Telescope search for transiting planets in the globular cluster 47 Tucanae, in the light of improved knowledge of planet occurrence from the Kepler mission. Gilliland and co-workers expected to find 17 planets, assuming the 47 Tuc stars have close-in giant planets with the same characteristics and occurrence rate as those of the nearby stars that had been surveyed up until 1999. We update this result by assuming that 47 Tuc and Kepler stars have identical planet populations. The revised number of expected detections is $4.0^{+1.7}_{-1.4}$. When we restrict the Kepler stars to the same range of masses as the stars that were searched in 47 Tuc, the number of expected detections is reduced to $2.2^{+1.6}_{-1.1}$. Thus, the null result of the HST search is less statistically significant than it originally seemed. We cannot reject even the extreme hypothesis that 47 Tuc and Kepler stars have the same planet populations, with more than 2-3$σ$ significance. More sensitive searches are needed to allow comparisons between the planet populations of globular clusters and field stars.
description: 10 pages, 4 figures, AJ accepted
Non-invasive control of excitons in two-dimensional materials
Creators: name: Steinke, Christina
name: Mourad, Daniel
name: Rösner, Malte
name: Lorke, Michael
name: Gies, Christopher
name: Jahnke, Frank
name: Czycholl, Gerd
name: Wehling, Tim O.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We investigate how external screening shapes excitons in two-dimensional (2d) semiconductors embedded in laterally structured dielectric environments. An atomic scale view of these elementary excitations is developed using models which apply to a variety of materials including transition metal dichalcogenides (TMDCs). We find that structured dielectrics imprint a peculiar potential energy landscape on excitons in these systems: While the ground-state exciton is least influenced, higher excitations are attracted towards regions with high dielectric constant of the environment. This landscape is "inverted" in the sense that low energy excitons are less strongly affected than their higher energy counterparts. Corresponding energy variations emerge on length scales of the order of a few unit cells. This opens the prospect of trapping and guiding of higher excitons by means of tailor-made dielectric substrates on ultimately small spatial scales.
MOESM1 of Evaluation of B1 inhomogeneity effect on DCE-MRI data analysis of brain tumor patients at 3T
Creators: name: Anirban Sengupta
name: Gupta, Rakesh
name: Anup Singh
Publisher: name: figshare
Year: 2017
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1. ROC analysis of different perfusion parameters before and after B1 correction.
Bayesian Analysis of Singly Imputed Synthetic Data under the Multivariate Normal Model
Creators: name: Guin, Abhishek
name: Roy, Anindya
name: Sinha, Bimal
Publisher: name: Bangladesh Academy of Sciences
Year: 2023

description: We develop appropriate Bayesian procedures to draw inference about the parameters under a multivariate normal model based on synthetic data. We consider two standard forms of synthetic data, generated under plug in sampling method and posterior predictive sampling method. In addition to point estimates of the mean vector and dispersion matrix, Bayesian credible sets for the mean vector and the generalized variance are also provided under both the scenarios. The analysis in the case when some (partial) features are sensitive and need to be hidden is also briey indicated
The Mechanistic Target of Rapamycin Complex 1 Pathway Contributes to the Anti-Tumor Effect of Granulocyte-Macrophage-Colony-Stimulating Factor-Producing T Helper Cells in Mouse Colorectal Cancer
Creators: name: Zhou, Hongjian
name: Jiang, Bin
name: Qian, Yuyuan
name: Ke, Chao
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: The role of granulocyte-macrophage-colony-stimulating factor-producing T helper (ThGM) cells in colorectal cancer (CRC) development remains unclear. This study characterizes the function of ThGM cells in mouse CRC. Mouse CRC was induced by administrating azoxymethane and dextran sulfate sodium. The presence of ThGM cells in CRC tissues and the mechanistic target of rapamycin complex 1 (mTORC1) signaling in ThGM cells was detected by flow cytometry. The impact of mTORC1 signaling on ThGM cell function was determined by in vitro culture. The effect of ThGM cells on CRC development was evaluated by adoptive transfer assays. ThGM cells, which expressed granulocyte-macrophage-colony-stimulating factor (GM-CSF), accumulated in CRC tissues. mTORC1 signaling is activated in CRC ThGM cells. mTORC1 inhibition by rapamycin suppressed ThGM cell differentiation and proliferation and resulted in the death of differentiating ThGM cells. mTORC1 inhibition in already differentiated ThGM cells did not induce significant cell death but decreased the expression of GM-CSF, interleukin-2, and tumor necrosis factor-alpha while impeding cell proliferation. Furthermore, mTORC1 inhibition diminished the effect of ThGM cells on driving macrophage polarization toward the M1 type, as evidenced by lower expression of pro-inflammatory cytokines, major histocompatibility complex class II molecule, and CD80 in macrophages after co-culture with rapamycin-treated ThGM cells. Lentivirus-mediated knockdown/overexpression of regulatory-associated protein of mTOR (Raptor) confirmed the essential role of mTORC1 in ThGM cell differentiation and function. Adoptively transferred ThGM cells suppressed CRC growth whereas mTORC1 inhibition abolished this effect. mTORC1 is essential for the anti-CRC activity of ThGM cells.
Routes Obey Hierarchy in Complex Networks
Creators: name: Csoma, Attila
name: Kőrösi, Attila
name: Rétvári, Gábor
name: Heszberger, Zalán
name: Bíró, József
name: Slíz, Mariann
name: Avena-Koenigsberger, Andrea
name: Griffa, Alessandra
name: Hagmann, Patric
name: Gulyás, András
Publisher: name: arXiv
Year: 2017
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Social and Information Networks (cs.SI)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Various hypotheses exist about the paths used for communication between the nodes of complex networks. Most studies simply suppose that communication goes via shortest paths, while others have more explicit assumptions about how routing (alternatively navigation or search) works or should work in real networks. However, these assumptions are rarely checked against real data. Here we directly analyze the structure of operational paths using real measurements. For this purpose we use existing and newly created datasets having both the topology of the network and a sufficient number of empirically-determined paths over it. Such datasets are processed for air transportation networks, the human brain, the Internet and the fit-fat-cat word ladder game. Our results suggest that from the great number of possible paths, nature seems to pick according to some simple rules, which we will refer to as routing policies. First we confirm, that the preference of short paths is an inevitable policy element, however the observed stretch of the paths suggests that there are other policies at work simultaneously. We identify two additional policies common in our networks: the "conform hierarchy", meaning that the paths should obey the structural hierarchy of the network, and the "prefer downstream" policy which promotes avoiding the network core if possible. Building upon these simple policies, we propose a synthetic routing policy which can recover the basic statistical properties of the operational paths in networks. Our results can be helpful in estimating the reaction of complex systems for stress coming from the outside more accurately than the shortest path assumption permits.
description: 8 pages 5 figures
Dirac equation, hydrogen atom spectrum and the Lamb shift in dynamical noncommutative spaces
Creators: name: Alavi, S. A.
name: Rezaei, N.
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Mathematical Physics (math-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We derive the relativistic Hamiltonian of hydrogen atom in dynamical noncommutative spaces (DNCS or τ-space). Using this Hamiltonian we calculate the energy shift of the ground state and as well the [2P]_(1/2), [2S]_(1/2) levels. In all cases the energy shift depend on the dynamical noncommutative parameter τ. Using the accuracy of the energy measurement we obtain an upper bound for τ. We also study the lamb shift in DNCS. Both the levels [2P]_(1/2) and [2S]_(1/2) receive corrections due to dynamical noncommutativity of space which is in contrast to the non-dynamical noncommutative spaces (NDNCS or θ-space) in which the level [2S]_(1/2) receives no correction.
description: 8 pages, 1 figure
Comments on Squashed-sphere Partition Functions
Creators: name: Bobev, Nikolay
name: Bueno, Pablo
name: Vreys, Yannick
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We study the partition function of odd-dimensional conformal field theories placed on spheres with a squashed metric. We establish that the round sphere provides a local extremum for the free energy which, in general, is not a global extremum. In addition, we show that the leading quadratic correction to the free energy around this extremum is proportional to the coefficient, $C_T$, determining the two-point function of the energy-momentum tensor in the CFT. For three-dimensional CFTs, we compute explicitly this proportionality constant for a class of squashing deformations which preserve an $SU(2)\times U(1)$ isometry group on the sphere. In addition, we evaluate the free energy as a function of the squashing parameter for theories of free bosons, free fermions, as well as CFTs holographically dual to Einstein gravity with a negative cosmological constant. We observe that, after suitable normalization, the dependence of the free energy on the squashing parameter for all these theories is nearly universal for a large region of parameter space and is well approximated by a simple quadratic function arising from holography. We generalize our results to five-dimensional CFTs and, in this context, we also study theories holographically dual to six-dimensional Gauss-Bonnet gravity.
description: 40 pages, 7 figures, 1 table; v2: additional comments and clarifications added, updated bibliography
Additional file 4 of Genetic toggle switch controlled by bacterial growth rate
Creators: name: Jaruszewicz-BĹOĹSka, Joanna
name: Lipniacki, Tomasz
Publisher: name: figshare
Year: 2017
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Figure S4. MFPT between the two states of the toggle switch. (PDF 97 kb)
Data Management Plan: second version
Creators: name: Gualandi, Bianca
name: Peroni, Silvio
Publisher: name: Zenodo
Year: 2024

description: This deliverable (D8) is the Data Management Plan of the Spoke 4. This Data Management Plan describes the categories of data that will be/is being produced by the project and details how they will be handled transparently and according to FAIR principles.

This deliverable is a living document and will evolve during the lifespan of the project. A previous version has already been published in M6, and a final updated version has already been planned for month M27. In addition, the DMP will be updated whenever important changes to data management or data management policy occur.
Why Do Cascade Sizes Follow a Power-Law?
Creators: name: Węgrzycki, Karol
name: Sankowski, Piotr
name: Pacuk, Andrzej
name: Wygocki, Piotr
Publisher: name: arXiv
Year: 2017
Subjects: subject: Social and Information Networks (cs.SI)
subject: Computers and Society (cs.CY)
subject: FOS: Computer and information sciences
subject: J.4

description: We introduce random directed acyclic graph and use it to model the information diffusion network. Subsequently, we analyze the cascade generation model (CGM) introduced by Leskovec et al. [19]. Until now only empirical studies of this model were done. In this paper, we present the first theoretical proof that the sizes of cascades generated by the CGM follow the power-law distribution, which is consistent with multiple empirical analysis of the large social networks. We compared the assumptions of our model with the Twitter social network and tested the goodness of approximation.
description: 8 pages, 7 figures, accepted to WWW 2017
Additional file 3 of Genetic toggle switch controlled by bacterial growth rate
Creators: name: Jaruszewicz-BĹOĹSka, Joanna
name: Lipniacki, Tomasz
Publisher: name: figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Figure S3. Stable stationary states of protein monomers level for different doubling times and different repression levels. (PDF 97 kb)
Cytokines Expression Compared to the Determinants of Cellular Apoptosis Prominently Attributes to the Deleterious Effects of ‘A’ Determinant Surface Gene Mutations in HBV Transfected Hepatoma Cell Line
Creators: name: Khan, Saniya
name: Anwer, Ayesha
name: Sevak, Jayesh Kumar
name: Trehanpati, Nirupama
name: Kazim, Syed Naqui
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Previous studies have explored the role of AKT protein in anti-apoptotic/proliferative activities. However, there has been a lack of information regarding the role of Akt in association with cytokines expression in HBV-related (wild type HBV and HBV with mutations of ‘a’ determinant region) studies either in the case of HBV infection or in transfected hepatoma cells. The present study tries to determine the role of Akt and cytokines expression in the presence of small surface gene mutants in the hepatoma cell line. Mutations of ‘a’ determinant region, viz. sA128V and sG145R, were created in wild-type pHBV1.3 by site-directed mutagenesis and transfected in hepatoma cell line. Secretory levels of HBsAg in the wild type as well as in both the mutants were analyzed by ELISA. Apoptotic analysis of transfected cells was studied by flow cytometry. Expression analysis of Akt and cytokines (TNF-alpha, IL-6, and IFN-gamma) was done by qPCR. The presence of significantly more alive cells in sG145R than sA128V transfected cells may be due to the up-regulation of the Akt gene expression. Cytokines expression was nearly similar between sA128V and wild-type pHBV1.3 transfected cells. Presence of sG145R showed dramatically high cytokines expression than sA128V and wild-type pHBV1.3. Cytokines expression predominantly contributes to the detrimental effects associated with the ‘a’ determinant region mutations particularly sG145R mutant. It may also be inferred that mechanisms associated with cellular apoptosis apparently do not play any major role to assign the ‘a’ determinant small surface gene mutation(s) for their pathological outcome.
Trapped modes in zigzag graphene nanoribbons
Creators: name: Kozlov, V. A.
name: Nazarov, S. A.
name: Orlof, A.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mathematical Physics (math-ph)
subject: Spectral Theory (math.SP)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We study a scattering on an ultra-low potential in zigzag graphene nanoribbon. Using mathematical framework based on the continuous Dirac model and augumented scattering matrix, we derive a condition for the existence of a trapped mode. We consider the threshold energies where the continuous spectrum changes its multiplicity and show that the trapped modes may appear for energies slightly less than a threshold and its multiplicity does not exceeds one. We prove that trapped modes do not appear outside the threshold, provided the potential is sufficiently small.
Gregory's sixth operation
Creators: name: Bascelli, Tiziana
name: Blaszczyk, Piotr
name: Kanovei, Vladimir
name: Katz, Karin U.
name: Katz, Mikhail G.
name: Kutateladze, Semen S.
name: Nowik, Tahl
name: Schaps, David M.
name: Sherry, David
Publisher: name: arXiv
Year: 2016
Subjects: subject: History and Overview (math.HO)
subject: Classical Analysis and ODEs (math.CA)
subject: Logic (math.LO)
subject: FOS: Mathematics
subject: 01A45, 26E35

description: In relation to a thesis put forward by Marx Wartofsky, we seek to show that a historiography of mathematics requires an analysis of the ontology of the part of mathematics under scrutiny. Following Ian Hacking, we point out that in the history of mathematics the amount of contingency is larger than is usually thought. As a case study, we analyze the historians' approach to interpreting James Gregory's expression ultimate terms in his paper attempting to prove the irrationality of pi. Here Gregory referred to the last or ultimate terms of a series. More broadly, we analyze the following questions: which modern framework is more appropriate for interpreting the procedures at work in texts from the early history of infinitesimal analysis? as well as the related question: what is a logical theory that is close to something early modern mathematicians could have used when studying infinite series and quadrature problems? We argue that what has been routinely viewed from the viewpoint of classical analysis as an example of an "unrigorous" practice, in fact finds close procedural proxies in modern infinitesimal theories. We analyze a mix of social and religious reasons that had led to the suppression of both the religious order of Gregory's teacher degli Angeli, and Gregory's books at Venice, in the late 1660s.
description: 17 pages, published in Foundations of Science
Stochastic Tools Hidden Behind the Empirical Dielectric Relaxation Laws
Creators: name: Stanislavsky, Aleksander
name: Weron, Karina
Publisher: name: arXiv
Year: 2017
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: The paper is devoted to recent advances in stochastic modeling of anomalous kinetic processes observed in dielectric materials which are prominent examples of disordered (complex) systems. Theoretical studies of dynamical properties of those "structures with variations" [Goldenfield and Kadanoff 1999 Science 284 87--9] require application of such mathematical tools by means of which their random nature can be analyzed and, independently of the details differing various systems (dipolar materials, glasses, semiconductors, liquid crystals, polymers, etc.), the empirical universal kinetic patterns can be derived. We begin with a brief survey of the historical background of the dielectric relaxation study. After a short outline of the theoretical ideas providing the random tools applicable to modeling of relaxation phenomena, we present probabilistic implications for the study of the relaxation-rate distribution models. In the framework of the probability distribution of relaxation rates we consider description of complex systems, in which relaxing entities form random clusters interacting with each other and single entities. Then we focus on stochastic mechanisms of the relaxation phenomenon. We discuss the diffusion approach and its usefulness for understanding of anomalous dynamics of the relaxing systems. We also discuss extensions of the diffusive approach to the systems under tempered random processes. Useful relationships among different stochastic approaches to the anomalous dynamics of complex systems allow us to get a fresh look on this subject. The paper closes with a final discussion on achievements of stochastic tools describing the anomalous time evolution of the complex systems.
description: Extended version, 80 pages, 14 figures, 4 tables
Universal properties of high-temperature superconductors from real-space pairing III: The role of correlated hopping and intersite Coulomb interaction within the t-J-U model
Creators: name: Zegrodnik, Michał
name: Spałek, Józef
Publisher: name: arXiv
Year: 2017
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We study the effect of the correlated hopping term and the intersite Coulomb interaction term on principal features of the $d$-$wave$ superconducting (SC) state, in both the electron and hole doped regimes within the t-J-U model. In our analysis we use the approach based on the diagrammatic expansion of the Gutzwiller wave function (DE-GWF) which allows us to go beyond the renormalized mean field theory (RMFT). We show that the correlated hopping term enhances the pairing at the electron-doped side of the phase diagram. Moreover, the so-called non-BCS regime (which manifests itself by the negative kinetic energy gain at the transition to the SC phase) is narrowed down with the increasing magnitude of the correlated hopping $\sim K$. Also, the doping dependences of the nodal Fermi velocity and Fermi momentum, as well as the average number of double occupancies, are analyzed with reference to the experimental data for selected values of the parameter $K$. For the sake of completeness, the influence of the intersite Coulomb repulsion on the obtained results is provided. Additionally, selected results concerning the Hubbard-model case are also presented. A complete model with all two-site interactions is briefly discussed in the Appendix for reference.
Additional file 4: Table S4. of Trends in prevalence, mortality, health care utilization and health care costs of Swiss IBD patients: a claims data based study of the years 2010, 2012 and 2014
Creators: name: Bähler, Caroline
name: Vavricka, Stephan
name: Schoepfer, Alain
name: Brüngger, Beat
name: Reich, Oliver
Publisher: name: figshare
Year: 2017
Subjects: subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Physician visits of the IBD versus the non-IBD sample for the year 2014 (n = 1,125,050). (DOCX 16 kb)
A search for H$α$ absorption around KELT-3 b and GJ 436 b
Creators: name: Cauley, P. Wilson
name: Redfield, Seth
name: Jensen, Adam G.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Observations of extended atmospheres around hot planets have generated exciting results concerning the dynamics of escaping planetary material. The configuration of the escaping planetary gas can result in asymmetric transit features, producing both pre- and post-transit absorption in specific atomic transitions. Measuring the velocity and strength of the absorption can provide constraints on the mass loss mechanism and, potentially, clues to the interactions between the planet and the host star. Here we present a search for H$α$ absorption in the circumplanetary environments of the hot planets KELT-3 b and GJ 436 b. We find no evidence for absorption around either planet at any point during the two separate transit epochs that each system was observed. We provide upper limits on the radial extent and density of the excited hydrogen atmospheres around both planets. The null detection for GJ 436 b contrasts with the strong Ly$α$ absorption measured for the same system, suggesting that the large cloud of neutral hydrogen is almost entirely in the ground state. The only confirmed exoplanetary H$α$ absorption to date has been made around the active star HD 189733 b. KELT-3 and GJ 436 are less active than HD 189733, hinting that exoplanet atmospheres exposed to EUV photons from active stars are better suited for H$α$ absorption detection.
description: 10 pages, 6 figures, accepted to AJ
ПЕРСИСТИРУЮЩАЯ ВИРУСНАЯ ИНФЕКЦИЯ У ДЕТЕЙ С БРОНХИАЛЬНОЙ АСТМОЙ
Creators: name: БУЛГАКОВА В.А.
name: БАЛАБОЛКИН И.И.
name: КАТОСОВА Л.К.
name: СЕНЦОВА Т.Б.
name: ЗУБКОВА И.В.
name: СЕДОВА М.С.
Publisher: name: Аллергология и Иммунология в Педиатрии
Year: 2011

description: Questions of interaction of an infection and allergy remain area of intensive epidemiological, immunological and clinical researches all over the world that is connected first of all with questions of preventive maintenance and adequate therapy of allergic illnesses. The understanding of a role of an infection in development and an allergy current, including an atopic bronchial asthma, has important clinical value for effective control over a clinical course. Authors of article have revealed high levels of detection at children with a bronchial asthma of virus and bacterial respiratory activators, basically associative character. It is shown that persistence of these activators promotes weighting of chronic inflammatory process in bronchial tubes, to development of a secondary immunodeficiency in which formation essential value can belong to infringements of processes apoptosis the immune cages, revealed at surveyed children.
Fast radio burst source properties and curvature radiation model
Creators: name: Kumar, Pawan
name: Lu, Wenbin
name: Bhattacharya, Mukul
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We use the observed properties of fast radio bursts (FRBs) and a number of general physical considerations to provide a broad-brush model for the physical properties of FRB sources and the radiation mechanism. We show that the magnetic field in the source region should be at least 10^{14} Gauss. This strong field is required to ensure that the electrons have sufficiently high ground state Landau energy so that particle collisions, instabilities, and strong electric and magnetic fields associated with the FRB radiation do not perturb electrons' motion in the direction transverse to the magnetic field and destroy their coherent motion; coherence is required by the high observed brightness temperature of FRB radiation. The electric field in the source region required to sustain particle motion for a wave period is estimated to be of order 10^{11} esu. These requirements suggest that FRBs are produced near the surface of magnetars perhaps via forced reconnection of magnetic fields to produce episodic, repeated, outbursts. The beaming-corrected energy release in these bursts is estimated to be ~10^{36} ergs, whereas the total energy in the magnetic field is at least ~10^{45} ergs. We provide a number of predictions for this model which can be tested by future observations. One of which is that short duration FRB-like bursts should exist at much higher frequencies, possibly up to optical.
description: 15 pages, 7 figures, MNRAS accepted
НЕКОТОРЫЕ ПРОБЛЕМНЫЕ ВОПРОСЫ В ДИАГНОСТИКЕ И ЛЕЧЕНИИ АТОПИЧЕСКОГО ДЕРМАТИТА У ДЕТЕЙ
Creators: name: АБЕЛЕВИЧ М.М.
Publisher: name: Аллергология и Иммунология в Педиатрии
Year: 2011

description: Atopic dermatitis has varied diagnostic and therapeutic features. There is no consensus in classification of this disease and topical glucocorticosteroids treatment. The same environmental exposure may induce different genetically predetermined response; the tactics of therapy depends on it. The allergen exposure at the early age determines increased probability of allergic diseases in future. For example, immune reaction on the house dust mite allergen exposure begins at the antenatal period. 65,7% of patients from the first days of life till the beginning of juvenility have the most frequent consequence: atopic dermatitis food allergy bronchial asthma. The affection of S. aureus and its toxins (super antigens) on the skin induce the production of allergen-specific antibodies (IgE), it determines the severity of atopic dermatitis and resistance to steroids. Topical glucocorticoids therapy decreased the skin affection by staphylococci. Prolonged non-halogen steroids of the modem generation may be used from the early age. The hydration and restoration of the dry skin integration are obligatory factors together with elimination of allergic and поп-allergic triggers. H l-blockers of the last generation inhibit the early and the late phases of allergic inflammation. Factors worsening the prognoses of atopic dermatitis are: family predisposition, the onset of disease during infancy, the severe intensity of disease during childhood, disease in females and concomitant allergic pathologies.
How close are time series to power tail Lévy diffusions?
Creators: name: Gairing, Jan
name: Högele, Michael A.
name: Kosenkova, Tania
name: Monahan, Adam H.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: This article presents a new and easily implementable method to quantify the so-called coupling distance between the law of a time series and the law of a differential equation driven by Markovian additive jump noise with heavy-tailed jumps, such as $α$-stable Lévy flights. Coupling distances measure the proximity of the empirical law of the tails of the jump increments and a given power law distribution. In particular they yield an upper bound for the distance of the respective laws on path space. We prove rates of convergence comparable to the rates of the central limit theorem which are confirmed by numerical simulations. Our method applied to a paleoclimate time series of glacial climate variability confirms its heavy tail behavior. In addition this approach gives evidence for heavy tails in data sets of precipitable water vapor of the Western Tropical Pacific.
description: 30 pages, 10 figures
АЛЛЕРГИЧЕСКИЙ РИНИТ У ДЕТЕЙ: ЧТО НОВОГО ДЛЯ ПЕДИАТРА И ДЕТСКОГО АЛЛЕРГОЛОГА В ДОКУМЕНТЕ ARIA?
Creators: name: ОВСЯННИКОВ Д.Ю.
Publisher: name: Аллергология и Иммунология в Педиатрии
Year: 2011

description: Allergic rhinitis (AR) in children is a common atopic condition with nasal and non-nasal symptoms, which is closely related to asthma. The review presents the basic statements of Aria Guidelines 2008 which include important information on current state of art in diagnostics and management of AR in children which are important for routine clinical practice of pediatricians and pediatric allergists.
Facile synthesis of sulfonamide libraries using a solid-polymer-supported HOBt scaffold
Creators: name: Guei, Jules Seh Noel
name: Kalivretenos, Aristotle
name: LaCourse, William
Publisher: name: Elsevier
Year: 2024

description: Using solid-phase synthetic methods, silica-bound 1-hydroxybenzotriazole (Si-HOBt) was prepared by coupling 3-aminopropyl silica gel with 1-hydroxybenzotriazole-6-carboxylic acid (HOBt-COOH). The Si-HOBt was activated by the reaction of Si-HOBT with 3,4-dihydroxy-9,10-dioxo-anthracenesulfonyl chloride (alizarin red S chloride), resulting in the activated Si-HOBt reagent. The reagent was used to prepare a combination library of sulfonamide derivatives of selected aliphatic and aromatic amines for the development of new therapeutics.
ДИНАМИКА ПОКАЗАТЕЛЕЙ МУКОЗАЛЬНОГО ИММУНИТЕТА, ЦИТОБАКТЕРИОЛОГИЧЕСКОГО И МОРФОФУНКЦИОНАЛЬНОГО СОСТОЯНИЯ СЛИЗИСТОЙ РОТОГЛОТКИ У ЧАСТО БОЛЕЮЩИХ ШКОЛЬНИКОВ ПОД ВЛИЯНИЕМ ГАЛОТЕРАПИИ. (ОКОНЧАНИЕ НАЧАЛО В № 1 ЗА 2011 ГОД)
Creators: name: ХАН М.А.
name: ЧЕРВИНСКАЯ А.В.
name: МИКИТЧЕНКО Н.А.
Publisher: name: Аллергология и Иммунология в Педиатрии
Year: 2011

description: The aim of this study was to assess the influence of halotherapy on mucosal immunity, cytobacteriological and morphofunctional state of oropharyngeal mucous membrane among children with acute respiratory disease (ARD). The study population comprised children with ARD symptoms received course of halotherapy and children without initially ARD symptoms received phylactic halotreatment. Children in the control group did not receive any halo-spray impact. The study have elicit the favorable effect of halotherapy, characterized by normalization of secretory IgA titers, improvement of morphofunctional state and protective function of oropharyngeal mucous membrane. On a base of the study differentiate models of halotherapy, according to a child initial health status, were constructed.
Internal wave attractors: different scenarios of instability
Creators: name: Brouzet, Christophe
name: Ermanyuk, E. V.
name: Joubaud, Sylvain
name: Pillet, Grimaud
name: Dauxois, Thierry
Publisher: name: arXiv
Year: 2017
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: This paper presents an experimental study of different instability scenarios in a parallelogram-shaped internal wave attractor in a trapezoidal domain filled with a uniformly stratified fluid. Energy is injected into the system via the oscillatory motion of a vertical wall of the trapezoidal domain. Whole-field velocity measurements are performed with the conventional PIV technique. In the linear regime, the total kinetic energyof the fluid system is used to quantify the strength of attractors as a function of coordinates in the parameter spacedefining their zone of existence, the so-called Arnold tongue. In the nonlinear regime, the choice of the operational point in the Arnold tongue is shown to have a significant impact on the scenario of the onset of triadic instability, most notably on the influence of confinement on secondary waves. The onset of triadic resonance instability may occur as a spatially localized event similar to Scolan, Ermanyuk and Dauxois (2013) in the case of strong focusing or in form of growing normal modes as in McEwan (1971) for the limiting case of rectangular domain. In the present paper, we describe also a new intermediate scenario for the case of weak focusing. We explore the long-term behaviour of cascades of triadic instabilities in wave attractors and show a persistent trend toward formation of standing-wave patterns corresponding to some discrete peaks of the frequency spectrum. At sufficiently high level of energy injection the system exhibits a "mixing box" regime which has certain qualitatively universal properties regardless to the choiceof the operating point in the Arnold tongue. In particular, for this regime, we observe a statisticsof events with high horizontal vorticity, which serve as kinematic indicators of mixing.
Additional file 2 of Genetic toggle switch controlled by bacterial growth rate
Creators: name: Jaruszewicz-BĹOĹSka, Joanna
name: Lipniacki, Tomasz
Publisher: name: figshare
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Figure S2. Gene copy numbers as a function of the doubling time. (PDF 77 kb)