cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Integrating Faidherbia albida trees into a sorghum field reduces striga infestation and improves mycorrhiza spore density and colonization
Creators: name: Birhane, Emiru
name: Gebremeskel, Kidu
name: Taddesse, Tewodros
name: Hailemariam, Mengsteab
name: Hadgu, Kiros Meles
name: Norgrove, Lindsey
name: Negussie, Aklilu
Publisher: name: Springer
Year: 2018
Subjects: Striga hermonthica
Sorghum
Grain yield
Faidherbia albida
Arbuscular mycorrhiza fungi
Ethiopia

description: Integrating agroforestry trees such as Faidherbia albida (F. albida) into cropland improves soil fertility and maintains persistence of associated beneficial microorganisms such as Arbuscular Mycorrhizal Fungi (AMF) that protects crops from striga colonization. Striga hermonthica (striga) is an obligate root hemi-parasitic weed of maize and sorghum, which stunts growth and causes low grain yield. Data on physico-chemical properties of the soil, yield components of sorghum, striga infestation and spore abundance and colonization of AM fungi were collected from underneath and away from the F. albida canopy. The experiment was composed of four treatments and six replications in a randomized complete block design (RCBD) with 24 plots, each with 15 m2 size. Soil and root samples were also collected from under and outside of the F. albida canopy and sorghum crops. Soil organic matter, total N, available P, CEC, and total K were significantly higher under the F. albida canopy than away from it (P < 0.05). Similarly, yield of sorghum was also significantly higher under the F. albida canopy than away from it (P < 0.05). The highest striga count was recorded away from the F. albida canopy. In contrast, minimal striga infestation was found under and at the periphery of the F. albida canopy. The spore density and colonization of AMF were higher under and at the periphery of the F. albida canopy than away from it (P < 0.05). There was a significant and negative correlation between AMF fungi spore density and colonization, and striga counts at the early stage of sorghum growth. Integrating F. albida into agricultural fields with sorghum crops improves productivity and maintains AM inoculum which may control striga weed infestation.
Additional file 4: of Health literacy and refugees’ experiences of the health examination for asylum seekers – a Swedish cross-sectional study
Creators: name: Wångdahl, Josefin
name: Lytsy, Per
name: Mårtensson, Lena
name: Westerling, Ragnar
Publisher: name: Figshare
Year: 2015
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: Proportions of respondents with non-good experiences about the communication quality and the usefulness of the health examination a . (DOCX 17 kb)
The Other Minna Wagner, Or: when Richard and Minna Can-Canned in Vienna
Creators: name: Walton, Christopher
Publisher: name: The Wagner Journal
Year: 2022

description: For over a century, images of "Minna Wagner" have been circulating in the literature on Richard Wagner's wife. However, three can now be proven to be of a different Minna Wagner, an actress and singer who on one occasion even performed in a Wagner parody in Vienna.
Tomato genome assembly note
Creators: name: Lee, Tong Geon
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 300199
subject: Agricultural biotechnology not elsewhere classified

description: Lee, T.G. Long-read DNA sequencing leads to the more complete sequence characterization of the fruit size reducing region flanking a Fusarium wilt resistance gene. Molecular Horticulture 2, 16 (2022). https://doi.org/10.1186/s43897-022-00037-w
Global shocks, cascading disruptions, and (re-)connections: viewing the COVID-19 pandemic as concurrent natural experiments to understand land system dynamics
Creators: name: Piquer-Rodríguez, María
name: Friis, Cecilie
name: Andriatsitohaina, R. Ntsiva N.
name: Boillat, Sébastien-Pierre
name: Roig-Boixeda, Paula
name: Cortinovis, Chiara
name: Geneletti, Davide
name: Ibarrola-Rivas, Maria-Jose
name: Kelley, Lisa C.
name: Llopis, Jorge C.
name: Mack, Elizabeth A.
name: Nanni, Ana Sofía
name: Zaehringer, Julie G.
name: Henebry, Geoffrey M.
Publisher: name: Springer
Year: 2023

description: Context For nearly three years, the COVID-19 pandemic has disrupted human well-being and livelihoods, communities, and economies in myriad ways with consequences for social-ecological systems across the planet. The pandemic represents a global shock in multiple dimensions that has already, and is likely to continue to have, far-reaching effects on land systems and on those depending on them for their livelihoods. Objectives We focus on the observed effects of the pandemic on landscapes and people composing diverse land systems across the globe. Methods We highlight the interrelated impacts of the pandemic shock on the economic, health, and mobility dimensions of land systems using six vignettes from different land systems on four continents, analyzed through the lens of socio-ecological resilience and the telecoupling framework. We present preliminary comparative insights gathered through interviews, surveys, key informants, and authors’ observations and propose new research avenues for land system scientists. Results The pandemic’s effects have been unevenly distributed, context-specific, and dependent on the multiple connections that link land systems across the globe. Conclusions We argue that the pandemic presents concurrent “natural experiments” that can advance our understanding of the intricate ways in which global shocks produce direct, indirect, and spillover effects on local and regional landscapes and land systems. These propagating shock effects disrupt existing connections, forge new connections, and re-establish former connections between peoples, landscapes, and land systems.
Electromethes Kazantsev, 2012, gen. n.
Creators: name: Kazantsev, Sergey V.
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Omethidae
Electromethes

description: Electromethes gen. n.
Type species: Electromethes alleni sp. n.
Description. Adult male. Alate, flattened, elongate (Fig. 1). Head transverse, exposed. Eyes moderately large, spherical. Labrum conspicuous, sclerotised, located anteriad of clypeus. Palps small, slender; ultimate palpomeres securiform. Gula transverse (Fig. 3). Antennal sockets separated by ca. their diameter. Antenna 11-segmented, moderately long, antennomeres 4–10 flabellate; pedicel (antennomere 2) short, subequal in length and width to antennomere 3 and considerably shorter than subsequent antennomeres; pubescence on antennomeres 3–11 short and decumbent (Fig. 2).
Pronotum transverse, narrowed and rounded anteriorly, with punctate convex disk, explanate sides and almost straight posterior angles (Figs 1–2). Prosternum triangular (Fig. 3). Scutellum elongate, rounded at apex (Fig. 1). Discrimen complete, bifurcate near mesoventrite. Elytra elongate, flattened, slightly broadening posteriorly, densely punctate, with inconspicuous longitudinal costae, pubescence short and decumbent (Fig. 1). Epipleuron absent. Metathoracic wings fully developed.
Legs relatively short and robust; hind coxae contiguous; trochanters short; femurs and tibiae straight, tibiae noticeably longer than femurs, almost non-widened distally; tarsomeres 1–4 slightly widened, with plantar pads; claws simple, shortly appendiculate at base.
Abdomen with eight ventrites; exposed portion of ultimate ventrite small, transverse, rounded at apex; ventrites without photic organs. Aedeagus with laterally exposed outside sternite 9 parameres (Fig. 3). Female. Unknown.
Diagnosis. Electromethes gen. n. is easily distinguishable from other omethids by a combination of the following characters: more prominent and more sclerotised labrum, securiform ultimate palpomeres, non-flabellate antennomere 3, location of the bases of flabellae of antennomeres 4–10 at the apices of antennomeres (Fig. 1), triangular prosternum (Fig. 3), absent elytral epipleuron, present plantar pads on tarsomeres 1–2 (Fig. 3), etc.
Etymology. The name of the new genus is derived from "electron", the Greek for "amber", and the genus name " Omethes ". Gender masculine.
description: Published as part of Kazantsev, Sergey V., 2012, New omethid and lampyrid taxa from the Baltic Amber (Insecta: Coleoptera), pp. 59-63 in Zootaxa 3186 on pages 59-61, DOI: 10.5281/zenodo.280009
A multidisciplinary approach to the antioxidant and hepatoprotective activities of Arbutus pavarii Pampan fruit; in vitro and in Vivo biological evaluations, and in silico investigations
Creators: name: Elshibani, Fatma A.
name: Alamami, Abdullah D.
name: Mohammed, Hamdoon A.
name: Rasheed, Rabab Ahmed
name: Sabban, Radwa M. El
name: Yehia, Mohamed A.
name: Mageed, Sherif S. Abdel
name: Majrashi, Taghreed A.
name: Elkaeed, Eslam B.
name: Hassab, Mahmoud A. El
name: Eldehna, Wagdy M.
name: El-Ashrey, Mohamed K.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biochemistry
Medicine
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: The Libyan Strawberry, Arbutus pavarii Pampan (ARB), is an endemic Jebel Akhdar plant used for traditional medicine. This study presents the antioxidant and hepatoprotective properties of ARB fruit-extract. ARB phytochemical analysis indicated the presence of 354.54 GAE and 36.2 RE of the phenolics and flavonoids. LC-MS analysis identified 35 compounds belonging to phenolic acids, procyanidins, and flavonoid glycosides. Gallic acid, procyanidin dimer B3, β-type procyanidin trimer C, and quercetin-3-O-glucoside were the major constituents of the plant extract. ARB administration to paracetamol (PAR)-intoxicated rats reduced serum ALT, AST, bilirubin, hepatic tissue MDA and proinflammatory markers; TNF-α and IL-6 with an increase in tissue GSH level and SOD activity. Histological and immunohistochemical studies revealed that ARB restored the liver histology and significantly reduced the tissue expression of caspase 3, IL-1B, and NF-KB in PAR-induced liver damage. Docking analysis disclosed good binding affinities of some compounds with XO, COX-1, 5-LOX, and PI3K.
Additional file 2 of Quantitative gene set analysis generalized for repeated measures, confounder adjustment, and continuous covariates
Creators: name: Turner, Jacob
name: Bolen, Christopher
name: Blankenship, Derek
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Documentation similar to that of an R help file defining the requirements of the Q-Gen function inputs and details. (DOCX 14.2 KB)
Additional file 1: Table S1. of Molecular characterisation of a novel recombinant Ribgrass mosaic virus strain FSHS
Creators: name: Chavan, Ramesh
name: Pearson, Michael
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Evolutionary Biology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Primers sets used to amplify the complete genome of Ribgrass mosaic virus strain FSHS isolated from Plantago major L. (DOCX 21 kb)
Electromethes alleni Kazantsev, 2012, sp. n.
Creators: name: Kazantsev, Sergey V.
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Omethidae
Electromethes
Electromethes alleni

description: Electromethes alleni sp. n.
(Figs 1–3)
Description. Male. Dark brown; elytral margins testaceous.
Eyes bulging, interocular dorsal distance over 3 times greater than eye radius. Maxillary and labial palps slen- der; ultimate maxillary palpomere elongate, ca, 3 times longer than wide, ultimate labial palpomere about 1,5 times longer than wide. Antennae flabellate, attaining to elytral middle, with antennomeres 2 and 3 combined about 2 times shorter than antennomere 4; flabellae of antennomeres 4–10 noticeably longer than antennomeres (Figs 1–2).
Pronotum transverse, ca. 1.5 times as wide as long, convex at disk, with noticeable anterior angles. Scutellum elongate, almost parallel-sided, rounded at apex (Fig. 1).
Elytra long, 3.4 times as long as wide at humeri (Fig. 1).
Tibiae ca. 1.2 times longer than femurs; tarsomere 1 almost as long as tarsomeres 2-4 combined (Fig. 3).
Length (from anterior head margin to end of elytra): 6.4 mm. Width (humerally): 1.7 mm.
Female. Unknown.
Type material: Holotype, 3, specimen No. L- 052011, Baltic amber, Upper Eocene (Insect Centre collection, Moscow).
Diagnosis. Electromethes alleni sp. n., the only known representative of the genus, is easily distinguishable from other omethids by the generic characters.
Etymology. The new species is named after Mr. Albert Allen (Boise, Idaho) who enabled me to study this remarkable Baltic Amber beetle specimen and donated the inclusion to the collection of the Insect Centre, Moscow.
description: Published as part of Kazantsev, Sergey V., 2012, New omethid and lampyrid taxa from the Baltic Amber (Insecta: Coleoptera), pp. 59-63 in Zootaxa 3186 on page 61, DOI: 10.5281/zenodo.280009
Watermelon: setup and validation of an in silico fragment-based approach
Creators: name: Di Stefano, Miriana
name: Galati, Salvatore
name: Piazza, Lisa
name: Gado, Francesca
name: Granchi, Carlotta
name: Macchia, Marco
name: Giordano, Antonio
name: Tuccinardi, Tiziano
name: Poli, Giulio
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Computational Biology

description: We present a new computational approach, named Watermelon, designed for the development of pharmacophore models based on receptor structures. The methodology involves the sampling of potential hotspots for ligand interactions within a protein target’s binding site, utilising molecular fragments as probes. By employing docking and molecular dynamics (MD) simulations, the most significant interactions formed by these probes within distinct regions of the binding site are identified. These interactions are subsequently transformed into pharmacophore features that delineates key anchoring sites for potential ligands. The reliability of the approach was experimentally validated using the monoacylglycerol lipase (MAGL) enzyme. The generated pharmacophore model captured features representing ligand-MAGL interactions observed in various X-ray co-crystal structures and was employed to screen a database of commercially available compounds, in combination with consensus docking and MD simulations. The screening successfully identified two new MAGL inhibitors with micromolar potency, thus confirming the reliability of the Watermelon approach.
MOESM3 of Identification of different malaria patterns due to Plasmodium falciparum and Plasmodium vivax in Ethiopian children: a prospective cohort study
Creators: name: Dinberu Seyoum
name: Yehenew Getachew Kifle
name: Rondeau, Virginie
name: Delenasaw Yewhalaw
name: Duchateau, Luc
name: Rosas-Aguirre, Angel
name: Speybroeck, Niko
Publisher: name: Figshare
Year: 2016
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 3. Martingal residual plots with corresponding lowess estimates (red line) (a) for P. vivax, (b) for P. falciparum.
Imparting aromaticity to 2-pyridone derivatives by O-alkylation resulted in new competitive and non-competitive PIM-1 kinase inhibitors with caspase-activated apoptosis
Creators: name: Abdelaziz, Marwa E.
name: El-Miligy, Mostafa M. M.
name: Fahmy, Salwa M.
name: Abu-Serie, Marwa M.
name: Hazzaa, Aly A.
name: Mahran, Mona A.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: New aromatic O-alkyl pyridine derivatives were designed and synthesised as Proviral Integration Moloney (PIM)-1 kinase inhibitors. 4c and 4f showed potent in vitro anticancer activity against NFS-60, HepG-2, PC-3, and Caco-2 cell lines and low toxicity against normal human lung fibroblast Wi-38 cell line. Moreover, 4c and 4f induced apoptosis in the four tested cancer cell lines with high percentage. In addition, 4c and 4f significantly induced caspase 3/7 activation in HepG-2 cell line. Furthermore, 4c and 4f showed potent PIM-1 kinase inhibitory activity with IC50 = 0.110, 0.095 µM, respectively. Kinetic studies indicated that 4c and 4f were both competitive and non-competitive inhibitors for PIM-1 kinase enzyme. In addition, in silico prediction of physiochemical properties, pharmacokinetic profile, ligand efficiency, ligand lipophilic efficiency, and induced fit docking studies were consistent with the biological and kinetic studies, and predicted that 4c and 4f could act as PIM-1 kinase competitive non-adenosine triphosphate (ATP) mimetics with drug like properties.
Novel alloxazine analogues: design, synthesis, and antitumour efficacy enhanced by kinase screening, molecular docking, and ADME studies
Creators: name: Samaha, Doaa
name: Mahmoud, Sawsan
name: Mohamed, Mosaad Sayed
name: Abdullah, Rokaia S.
name: Taleb, Nageh A. Abou
name: Nagamatsu, Tomohisa
name: Ali, Hamed I.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: This study describes the development of novel alloxazine analogues as potent antitumor agents with enhanced selectivity for tumour cells. Twenty-nine out of 45 newly compounds were investigated in vitro for their growth inhibitory activities, against two human tumour cell lines, namely, the human T-cell acute lymphoblastoid leukaemia cell line (CCRF-HSB-2) and human oral epidermoid carcinoma cell line (KB), and the antitumor agent “Ara-C” was used as a positive reference in this investigation. Compounds 9e and 10J were the highest among their analogues, against both tumour cell lines (CCRF-HSB-2 and KB). Correlation analyses demonstrated a strong relationship between the IC50 values and AutoDock binding free energy or calculated inhibition (Ki). The study delves into structure–activity relationships (SARs) through advanced modelling tools integrated with structure-based drug design (SBDD) using GOLD 5.2.2, AutoDock 4.2, and Accelrys Discovery Studio 3.5. Physicochemical properties, pharmacokinetics, drug-likeness, and toxicity predictions of the most potent alloxazine derivatives were conducted using ProTox-II and Swiss ADME for effective antitumor agents with improved selectivity.
MOESM2 of Identification of different malaria patterns due to Plasmodium falciparum and Plasmodium vivax in Ethiopian children: a prospective cohort study
Creators: name: Dinberu Seyoum
name: Yehenew Getachew Kifle
name: Rondeau, Virginie
name: Delenasaw Yewhalaw
name: Duchateau, Luc
name: Rosas-Aguirre, Angel
name: Speybroeck, Niko
Publisher: name: Figshare
Year: 2016
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 2. Plasmodium falciparum and Plasmodium vivax episodes by village in south western Ethiopia (July 2008â  June 2010).
MOESM1 of Identification of different malaria patterns due to Plasmodium falciparum and Plasmodium vivax in Ethiopian children: a prospective cohort study
Creators: name: Dinberu Seyoum
name: Yehenew Getachew Kifle
name: Rondeau, Virginie
name: Delenasaw Yewhalaw
name: Duchateau, Luc
name: Rosas-Aguirre, Angel
name: Speybroeck, Niko
Publisher: name: Figshare
Year: 2016
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1. Recurrent malaria episode data representation for a sample of four children: (a) four children follow-up history; (b) children malaria episode information using calendar timescale or counting process approach.
Additional file 2: of Assessment of an automated capillary system for Plasmodium vivax microsatellite genotyping
Creators: name: Manrique, Paulo
name: Hoshi, Mari
name: Fasabi, Manuel
name: Nolasco, Oscar
name: Yori, Pablo
name: Martiza Calderรณn
name: Gilman, Robert
name: Kosek, Margaret
name: Vinetz, Joseph
name: Dionicia Gamboa
Publisher: name: Figshare
Year: 2015
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: A sequenced PCR product of 227 base pairs used.
Additional file 1: Figure S1. of Evidence of cAMP involvement in cellobiohydrolase expression and secretion by Trichoderma reesei in presence of the inducer sophorose
Creators: name: Nogueira, Karoline
name: Costa, Mariana
name: Paula, Renato De
name: Mendonça-Natividade, Flávia
name: Ricci-Azevedo, Rafael
name: Silva, Roberto
Publisher: name: Figshare
Year: 2015
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Computational Biology

description: Growth profiles of T. reesei QM9414 and Δacy1 strains in cellulose (A) and glycerol (B) as carbon source. Error bars are represented from three biological replicates. No significant difference was showed in growth between ∆acy1 mutant strain and the parental QM9414 (PDF 117 kb)
Identification of putative allosteric inhibitors of BCKDK via virtual screening and biological evaluation
Creators: name: Li, Chunqiong
name: Yang, Quanjun
name: Zhang, Li
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Virology

description: Abnormal accumulation of branched-chain amino acids (BCAAs) can lead to metabolic diseases and cancers. Branched-chain α-keto acid dehydrogenase kinase (BCKDK) is a key negative regulator of BCAA catabolism, and targeting BCKDK provides a promising therapeutic approach for diseases caused by BCAA accumulation. Here, we screened PPHN and POAB as novel putative allosteric inhibitors by integrating allosteric binding site prediction, large-scale ligand database virtual screening, and bioactivity evaluation assays. Both of them showed a high binding affinity to BCKDK, with Kd values of 3.9 μM and 1.86 μM, respectively. In vivo experiments, the inhibitors demonstrated superior kinase inhibitory activity and notable antiproliferative and proapoptotic effects on diverse cancer cells. Finally, bulk RNA-seq analysis revealed that PPHN and POAB suppressed cell growth through a range of signalling pathways. Taken together, our findings highlight two novel BCKDK inhibitors as potent therapeutic candidates for metabolic diseases and cancers associated with BCAA dysfunctional metabolism.
Additional file 4: of Interpreting whole genome sequencing for investigating tuberculosis transmission: a systematic review
Creators: name: Hollie-Ann Hatherell
name: Colijn, Caroline
name: Stagg, Helen
name: Jackson, Charlotte
name: Winter, Joanne
name: Abubakar, Ibrahim
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy

description: Appendix D. Included studies and extracted data. (DOCX 32 kb)
Additional file 5: of Interpreting whole genome sequencing for investigating tuberculosis transmission: a systematic review
Creators: name: Hollie-Ann Hatherell
name: Colijn, Caroline
name: Stagg, Helen
name: Jackson, Charlotte
name: Winter, Joanne
name: Abubakar, Ibrahim
Publisher: name: Figshare
Year: 2016
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Science Policy
subject: 60506 Virology

description: Appendix E. Factors affecting the number of polymorphisms detected in sequences. (DOCX 18 kb)
Electotreta Kazantsev, 2012, gen. n.
Creators: name: Kazantsev, Sergey V.
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Lampyridae
Electotreta

description: Electotreta gen. n.
Type species: Electotreta rasnitsyni sp. n.
Description. Adult male. Alate, flattened, elongate (Fig. 4). Head transverse, almost completely covered by pronotum. Eyes relatively large, spherical. Ultimate palpomeres distally pointed. Antennal sockets broadly separated. Antenna 11-segmented, moderately long, filiform; pedicel (antennomeres 2) subequal in length to antennomere 3 and subsequent antennomeres; pubescence on antennomeres 3–11 short and sub-erect (Figs 4–5).
Pronotum small, ca. 6 times shorter than elytra, transverse, narrowed and rounded anteriorly, with smooth convex disk and prominent acute posterior angles (Fig. 4). Scutellum triangular, with minute emarginate at apex (Fig. 4). Elytra elongate, flattened, parallel-sided, with prominent humeral costa, noticeable in proximal three fourths, and ten rows of even round impressions, six rows in discal part and four rows in lateral part, apices independently rounded; pubescence sub-erect and short (Fig. 4). Epipleuron short, noticeable near humerus (Fig. 5). Metathoracic wings fully developed.
Legs slender; trochanters elongate; femurs and tibiae narrow, tibiae straight, slightly widened distally; tarsomeres 2–4 slightly widened, with plantar pads; claws simple, with a small broad tooth at base.
Abdomen with six ventrites, strongly narrowed distally; ultimate ventrite elongate, almost parallel-sided; penultimate equally narrow, short. Ventrites without photic organs.
Female. Unknown.
Diagnosis. Electotreta gen. n. is easily distinguishable from other ototretines by the dorsally smooth head, transverse pronotum with prominent acute posterior angles and ten rows of round impressions on each elytron (Fig. 4).
Etymology. The name of the new genus is derived from "electron", the Greek for "amber", and the genus name "Ototreta". Gender feminine.
Remarks. Ototretines (Drilaster, Stenocladius Fairmaire, 1878 and allied genera), initially treated as drilids (e.g., Wittmer, 1944), were afterwards included in Lampyridae (McDermott, 1964; Crowson, 1972), and recently transferred to Cantharidae (Bouchard et al., 2011). However, the latter transfer was made without argumentation, and this lineage perhaps should be retained in Lampyridae, pending further study, as apparently not fitting in Cantharidae, due to, for instance, the free labrum of its representatives, as opposed to the fused labrum in the cantharids. Obviously, these East-Asian beetles need to be comprehensively studied to be properly classified.
Most of the head and thoracic structures of the inclusion are obscured below by air bulbs and detritus particles.
description: Published as part of Kazantsev, Sergey V., 2012, New omethid and lampyrid taxa from the Baltic Amber (Insecta: Coleoptera), pp. 59-63 in Zootaxa 3186 on pages 61-62, DOI: 10.5281/zenodo.280009
Design, synthesis, and apoptotic antiproliferative action of new 1,2,3-triazole/1,2,4-oxadiazole hybrids as dual EGFR/VEGFR-2 inhibitors
Creators: name: Mahmoud, Mohamed A.
name: Mohammed, Anber F.
name: Salem, Ola I. A.
name: Almutairi, Tahani Mazyad
name: Bräse, Stefan
name: Youssif, Bahaa G. M.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Medicine
Cell Biology
Molecular Biology
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Developmental Biology
Cancer

description: A novel series of 1,2,3-triazole/1,2,4-oxadiazole hybrids (7a–o) was developed as dual inhibitors of EGFR/VEGFR-2. Compounds 7a–o were evaluated as antiproliferative agents with Erlotinib as the reference drug. Results demonstrated that most of the tested compounds showed significant antiproliferative action with GI50 values ranging from 28 to 104 nM, compared to Erlotinib (GI50 = 33 nM), and compounds 7i–m were the most potent. Compounds 7h, 7i, 7j, 7k, and 7l were evaluated as dual EGFR/VEGFR-2 inhibitors. These in vitro experiments demonstrated that compounds 7j, 7k, and 7l are potent antiproliferative agents that may operate as dual EGFR/VEGFR-2 inhibitors. Compounds 7j, 7k, and 7l were evaluated for their apoptotic potential activity, where findings indicated that compounds 7j, 7k, and 7l promote apoptosis by activating caspase-3, 8, and Bax and down-regulating the anti-apoptotic Bcl-2. Molecular docking simulations show the binding mode of the most active antiproliferative compounds within EGFR and VEGFR-2 active sites.
Im Dialog mit der Soziokultur: Eine Diskursanalyse der Fachdebatte zur Soziokulturellen Animation
Creators: name: Bezzola, Franco
name: Gäumann, Simone
Publisher: name: Hochschule Luzern, Soziale Arbeit, Institut für Soziokulturelle Entwicklung
Year: 2017

description: Vielseitig und umtriebig präsentiert sich die Soziokulturelle Animation in ihrer Praxis. Im Rahmen ihrer Projekte und Initiativen werden Partizipationsprozesse moderiert, lokale Akteure und Aktivitäten vernetzt, Jugendtreffpunkte und Kulturhäuser betreut, generationenübergreifende Begegnungen geschaffen, Integrationsprojekte gefördert und Kurs- und Bildungsprogramme organisiert mit dem Ziel das Gemeinwesen weiterzuentwickeln. Bei näherer Betrachtung erweisen sich die Arbeitsfelder und Tätigkeitsbereiche der Soziokulturellen Animation als äusserst vielschichtig und heterogen und lassen sich nur schwer als Einheit fassen. Eine Definition oder zumindest eine einheitliche Beschreibung würde, darüber sind sich viele Involvierte einig, ihre fachliche Weiterentwicklung wesentlich vereinfachen. Zu ihren Eigenschaften gehört es jedoch, dass sie sich nicht nur gegen eine einheitliche Definition sperrt, sondern sich einer solchen geradezu verwehren will. Ein Forschungsprojekt der Hochschule Luzern – Soziale Arbeit hat diese Ausgangslage aufgegriffen mit dem Ziel, einen Beitrag zu leisten für eine wissenschaftsorientierte Weiterentwicklung der Soziokulturellen Animation. Die vorliegende Untersuchung analysiert aus diskursanalytischer Perspektive die Beschreibung und Bestimmung der Soziokulturellen Animation in ihren eigenen fachlichen Grundlagen und deckt damit ihre Konstruktionsbedingungen und -strategien auf. Diese Lesart soll die Soziokulturelle Animation als Gegenstand kritisch analysieren und auszudifferenzieren, um daraus weiterführende Anhaltspunkte und Fragestellungen für den fachlichen Diskurs zu gewinnen.
Additional file 5: Table S1. of Chemoprotection of murine hematopoietic cells by combined gene transfer of cytidine deaminase (CDD) and multidrug resistance 1 gene (MDR1)
Creators: name: Brennig, Sebastian
name: Lachmann, Nico
name: Buchegger, Theresa
name: Hetzel, Miriam
name: Schambach, Axel
name: Moritz, Thomas
Publisher: name: Figshare
Year: 2015
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology

description: In vitro selection of primary hematopoietic gene-modified cells. Data for in vitro selection experiments are given as % GFP+ cells (three days post treatment). (DOC 28 kb)
Design, synthesis, and biological evaluation of piperazine derivatives involved in the 5-HT1AR/BDNF/PKA pathway
Creators: name: Zhou, Hao
name: Li, Mengjiao
name: Liu, Hui
name: Liu, Zheng
name: Wang, Xuekun
name: Wang, Shiben
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Mental Health

description: In this study, four series of piperazine derivatives were designed, synthesised and subjected to biological test, and compound 6a with potential antidepressant activity was obtained. An affinity assay of compound 6a with 5-hydroxytryptamine (serotonin, 5-HT)1A receptor (5-HT1AR) was undertaken, and the effects on the 5-HT level in the brains of mice were also tested. The results showed that compound 6a had the best affinity with 5-HT1AR (Ki = 1.28 nM) and significantly increased the 5-HT level. The expression levels of 5-HT1AR, BDNF, and PKA in the hippocampus were analysed by western blot and immunohistochemistry analyses. The results showed that the expression of 5-HT1AR, BDNF, and PKA in the model group was reduced compared to that of the control group, and compound 6a could reverse this phenomenon. Molecular docking was performed to investigate the interactions of the studied compound 6a with 5-HT1AR on the molecular level.
title: Advancing crowdsourced  data collection for tsunami hazard and impact information with users
Creators: name: Harrison, Sara E.
name: Charlton, Danielle H.
name: Lawson, Rachel V.
name: Potter, Sally H.
name: Clark, Kate J.
name: Houltham, Jeremy
name: Inglis, Sarah
name: Clive, Mary Anne
Publisher: name: GNS Science
Year: 2024

description: Crowdsourcing has been established as a viable method for collecting real-time hazard and impact information, yet it is currently under-utilised. This project aims to progress efforts toward the vision of collecting data to support a more complete understanding of real-time hazard and impacts that are occurring across Aotearoa New Zealand in an inclusive and participatory way. We co-created and tested an online geospatial reporting form for collecting crowdsourced hazard and impact observations for tsunami as a pilot for wider application across the geohazards. This process included investigating what hazard and impact information is most useful to collect for tsunami from a scientific and user-needs perspective, including aligning with international standards. To co-create the reporting form, virtual workshops with tsunami, risk and social science
data users (N = 8) were used to identify and prioritise questions to include that would produce useful data for tsunami, risk and social scientists, as well as emergency managers and responders. Previous tsunami observation surveys were used as a foundation for this development process. The user testing involved in-person interviews (N = 9) with members of the public to capture their experiences of completing and submitting a fictional tsunami report and interacting with resulting web-maps. The draft tsunami reporting form was also sent to technical users through New Zealand’s Tsunami Working Group and Geospatial Emergency Management Aotearoa community, along with a feedback questionnaire to collect structured feedback on the design of the survey and perceived value of the resulting data.
This project produced good-practise standards for GNS Science to collect real-time crowdsourced hazard and impact information for tsunami. The standard also sets a foundation for translating crowdsourced reporting to other perils, such as volcano, landslides and earthquakes, in future work (auths)
Bruchversuche an Stahlbetonscheiben
Creators: name: Maier, Johannes
name: Thürlimann, Bruno
Publisher: name: ETH Zurich
Year: 1985
Subjects: SCHEIBEN + TRAGWÄNDE + SCHEIBENTRAGWERKE (BAUSTATIK)
STAHLBETON, SCHLAFF BEWEHRT (BAUSTOFFE)
BRUCH, BRUCHGEFÜGE, BRUCHFESTIGKEIT (MATERIALPRÜFUNG)
DEEP BEAMS + LOAD BEARING WALLS + DISKS (STRUCTURAL ANALYSIS)
REINFORCED CONCRETE, UNSTRESSED (BUILDING MATERIALS)
FRACTURE, FRACTURE MECHANICS (MATERIALS TESTING)
info:eu-repo/classification/ddc/690
Buildings

description: Bericht / Institut für Baustatik und Konstruktion ETH Zürich, 8003 (1)
Wenn Armutsbetroffene Gesundheitsleistungen nicht in Anspruch nehmen
Creators: name: Coullery, Pascal
name: Soom Ammann, Eva
Publisher: name: Berner Fachhochschule BFH, Soziale Arbeit
Year: 2021

description: Die 4. Tagung "Gesundheit und Armut" brachte am 21. Januar ein heterogenes Publikum aus der ganzen Schweiz zusammen. Mit dem Verzicht auf Gesundheitsleistungen aus finanziellen Gründen stand ein gesellschaftspolitisch, ökonomisch und ethrisch brisantes Thema im Fokus. Die diversen Perspektiven auf das Thema animierten dazu, Lösungsansätze anzudenken.
MOESM3 of Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17 pathway in acute renal failure associated to Plasmodium falciparum malaria
Creators: name: Herbert, Fabien
name: Tchitchek, Nicolas
name: Bansal, Devendra
name: Jacques, Julien
name: Sulabha Pathak
name: BĂŠcavin, Christophe
name: Fesel, Constantin
name: Dalko, Esther
name: Pierre-AndrĂŠ Cazenave
name: Preda, Cristian
name: Ravindran, Balachandran
name: Shobhona Sharma
name: Bidyut Das
name: Pied, Sylviane
Publisher: name: Figshare
Year: 2015
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 3: Figure S3. Set of cytokines characterized by relatively lower levels of expression during malaria. Boxplots and plot-jittering representations showing cytokine distributions across different subpehnotypes of malarial patients and controls. Box plots show the first and third quartiles, together with the medians of the cytokines levels expressed as log10-transformed values (ng/mL of plasma) across categories of malarial patients (MM, SNCM, MOD, CM, CM-MOD) and controls (EC, SEPT, ENC). Individual cytokines within each category are represented using a jittering method in order to reduce display overlap.
Photogrammetrische Punktbestimmung mit der Bündelmethode: Leistungssteigerung durch Kompensation systematischer und Elimination grober Fehler
Creators: name: Grün, Armin
Publisher: name: ETH Zurich
Year: 1986
Subjects: LAGEFESTPUNKTE + TRIGONOMETRISCHE PUNKTE + POLYGONPUNKTE (GEODÄSIE)
BILDTRIANGULATION + AEROTRIANGULATION + PASSPUNKTBESTIMMEN (GEODÄSIE)
ALGEBRAISCHE GARBEN (ALGEBRAISCHE GEOMETRIE)
PLANIMETRIC STATIONS + TRIGONOMETRIC STATIONS + TRAVERSE STATIONS (GEODESY)
PHOTOGRAMMETRIC AERIAL TRIANGULATION + DETERMINATION OF CONTROL POINTS AND PASS POINTS (GEODESY)
ALGEBRAIC SHEAVES (ALGEBRAIC GEOMETRY)
info:eu-repo/classification/ddc/550
Earth sciences

description: Mitteilungen / Institut für Geodäsie und Photogrammetrie an der Eidgenössischen Technischen Hochschule Zürich, 40
Electotreta rasnitsyni Kazantsev, 2012, sp. n.
Creators: name: Kazantsev, Sergey V.
Publisher: name: Zenodo
Year: 2012
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Lampyridae
Electotreta
Electotreta rasnitsyni

description: Electotreta rasnitsyni sp. n.
(Figs 4–5)
Description. Male. Testaceous; elytra dark brown.
Eyes bulging, interocular dorsal distance ca. 3 times greater than eye radius. Maxillary and labial palps slender; ultimate maxillary palpomere elongate, ultimate labial palpomere roundish. Antennae filiform, attaining to elytral two fifths, with antennomere 3 subequal in length to pedicel (antennomere 2) and only slightly shorter than scape (Fig. 4).
Pronotum strongly transverse, ca. 2.4 times as wide as long, strongly narrowed anteriorly, margined throughout, with prominent acute posterior angles; disk sparsely punctate. Scutellum transverse, triangular, slightly emarginate at apex (Fig. 4).
Elytra elongate, 2.6 times as long as wide at humeri (Fig. 1); with ten rows of round impressions in the middle transforming into six rows at apices.
Terminal abdominal ventrite elongate, almost parallel-sided, with rounded apex, ca. 2 times longer than wide and longer than two preceding ventrites together (Fig. 5).
Length (from anterior head margin to end of elytra): 2.3 mm. Width (humerally): 0.8 mm.
Female. Unknown.
Type material: Holotype, 3, specimen No. L- 042011, Palanga, Lithuania, Baltic amber, Upper Eocene (Insect Centre collection, Moscow).
Diagnosis. Electotreta rasnitsyni sp. n., the only known representative of the genus, is easily distinguishable from other ototretines by the generic characters.
Etymology. The new species is named after a prominent palaeоentomologist Dr. A.P. Rasnitsyn (Moscow).
description: Published as part of Kazantsev, Sergey V., 2012, New omethid and lampyrid taxa from the Baltic Amber (Insecta: Coleoptera), pp. 59-63 in Zootaxa 3186 on pages 62-63, DOI: 10.5281/zenodo.280009
Plant functional groups mediate drought resistance and recovery in a multisite grassland experiment
Creators: name: Mackie, Kathleen A.
name: Zeiter, Michaela
name: Bloor, Juliette M. G.
name: Stampfli, Andreas
Publisher: name: Wiley
Year: 2018

description: 1.Climate change predictions suggest that summer droughts will become more intense and recurrent in Europe. While drought‐induced reductions in grassland primary productivity are well documented, the drivers behind drought resistance (the capacity to withstand change) and recovery (the capacity for recovery of function) of above‐ and below‐ground biomass remain poorly understood. 2.Across eight grasslands differing in plant community productivity (CP), we investigated the effects of summer drought on plant and soil microbial variables, plant nutrient content, and soil nitrogen (N) availability. We examined the linkages between CP, soil N, drought responses of plant and microbial communities, and relative drought responses of plant and microbial biomass. Plant and microbial variables were recorded at the end of a 3‐month rainfall exclusion period. Plant variables were also assessed during a 10‐month drought recovery period. 3.Experimental drought decreased plant biomass and increased plant C:N ratios, but had no effect on total microbial biomass across sites. Instead, drought caused shifts in plant and microbial community structures as well as an increase in arbuscular mycorrhiza fungi biomass. Overall, plant biomass drought resistance was unrelated to CP or microbial community structure but was positively related to drought resistance of forbs. 4.In the month after rewetting, soil N availability increased in droughted plots across sites. Two months post‐rewetting, droughted plots had higher plant N concentration, but lower plant N use efficiency. The short‐term drought recovery of plant biomass was unrelated to CP or soil N availability, but positively related to the response of grass biomass, reflecting incomplete recovery at high CP. Ten months after rewetting, drought effects on plant biomass and plant N content were no longer apparent. 5.Synthesis. Our results suggest that drought resistance and recovery are more sensitive to plant community composition than to community productivity. Short‐term recovery of plant biomass may also benefit from increased soil N availability after drought and from a high abundance of soil fungi in low productivity sites. Our findings underline the importance of plant functional groups for the stability of permanent grasslands in a changing climate with more frequent drought.
MOESM5 of Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17 pathway in acute renal failure associated to Plasmodium falciparum malaria
Creators: name: Herbert, Fabien
name: Tchitchek, Nicolas
name: Bansal, Devendra
name: Jacques, Julien
name: Sulabha Pathak
name: BĂŠcavin, Christophe
name: Fesel, Constantin
name: Dalko, Esther
name: Pierre-AndrĂŠ Cazenave
name: Preda, Cristian
name: Ravindran, Balachandran
name: Shobhona Sharma
name: Bidyut Das
name: Pied, Sylviane
Publisher: name: Figshare
Year: 2015
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 5: Table S1. Discriminant cytokines distinguishing controls and malaria groups.
Das photogrammetrische Zweibildmodell als Spezialfall eines Mess-Netzwerkes
Creators: name: Zollinger, Hansjürg
Publisher: name: ETH Zurich
Year: 1985
Subjects: PHOTOGRAMMETRISCHE AUSWERTUNG (GEODÄSIE)
TRIGONOMETRISCHE NETZE (GEODÄSIE)
RESTITUTION OF PHOTOGRAMS (GEODESY)
TRIGONOMETRIC NETWORKS (GEODESY)
info:eu-repo/classification/ddc/550
Earth sciences

description: Mitteilungen / Institut für Geodäsie und Photogrammetrie an der Eidgenössischen Technischen Hochschule Zürich, 39