cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Membrane core-specific antimicrobial action of Cathelicidin LL-37 peptide switches between pore and nanofibre formation
Creators: name: Shahmiri, Mahdi
name: Enciso, M
name: Adda, Christopher
name: Smith, Brian
name: Perugini, Matthew
name: Mechler, Adam
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3101
subject: Biochemistry and cell biology
classificationCode: 51
subject: Physical sciences
subject: FOS: Physical sciences

description: Membrane-disrupting antimicrobial peptides provide broad-spectrum defence against localized bacterial invasion in a range of hosts including humans. The most generally held consensus is that targeting to pathogens is based on interactions with the head groups of membrane lipids. Here we show that the action of LL-37, a human antimicrobial peptide switches the mode of action based on the structure of the alkyl chains, and not the head groups of the membrane forming lipids. We demonstrate that LL-37 exhibits two distinct interaction pathways: pore formation in bilayers of unsaturated phospholipids and membrane modulation with saturated phospholipids. Uniquely, the membrane modulation yields helical-rich fibrous peptide-lipid superstructures. Our results point at alternative design strategies for peptide antimicrobials.
Transcriptome and long noncoding RNA sequencing of three extracellular vesicle subtypes released from the human colon cancer LIM1863 cell line
Creators: name: Chen, Maoshan
name: Xu, Rong
name: Ji, H
name: Greening, David
name: Rai, Alin
name: Izumikawa, K
name: Ishikawa, H
name: Takahashi, N
name: Simpson, Richard
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3102
subject: Bioinformatics and computational biology
classificationCode: 3105
subject: Genetics

description: Previously we reported that LIM1863 colorectal cancer (CRC) cells secrete three distinct extracellular vesicle subtypes-two subpopulations of exosomes (apical EpCAM-Exos and basolateral A33-Exos) and shed microvesicles (sMVs)-with distinct protein and miRNA signatures. Here, we extend our omics approach to understand the fundamental role of LIM1863-derived EVs by performing a comprehensive analysis of their mRNAs and long non-coding RNAs (lncRNAs) using RNA-Seq. We show that 2,389 mRNAs, 317 pseudogene transcripts, 1,028 lncRNAs and 206 short non-coding RNAs selectively distributed to (i.e., are enriched in) LIM1863 EVs, relative to the parent cell. An Ensembl/UniProtKB analysis revealed 1,937 mRNAs encode canonical proteins, 348 isoforms (including splice-variant proteins), and 119 'missing proteins' (i.e., annotated in Ensembl but not UniProtKB). Further dissection of our protein/RNA data revealed that 6/151 observed RNA binding proteins have the potential to interact with ∼75% of EV-enriched RNAs. Intriguingly, the co-existence of U1 and U2 ribonucleoproteins and their cognate snRNAs in LIM1863 EVs suggests a possible association of CRC EVs with recipient cell splicing events. Our data reveal several potential lncRNA CRC biomarkers and novel splicing/fusion genes that, collectively, will advance our understanding of EV biology in CRC and accelerate the development of EV-based diagnostics and therapeutics.
An effective gauge field theory of the nucleon interactions
Creators: name: Boos, Eduard
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We discuss the possibility of constructing an effective gauge field theory of the nucleon interations based on the ideas of isotopic invariance as well as hypercharge invariance as a local gauge symmetry and spontaneous breaking of this symmetry. The constructed model predicts the structure of interactions of protons and neutrons with $ρ$- and $σ$-mesons, with pi-mesons and photons, as well as interactions of these particles with each other. The Lagrangian of the model consists of several parts parts involving dimension 4 and 5 gauge invariant operators. Feynman rules for physical degrees of freedom as follow from the Lagrangian define the structure of diagrams for one-boson exchanges between nucleons predicting the internucleon one-boson exchange potential as well as nucleon scattering amplitudes. The range of applicability of the model is discussed and estimates are made of the resulting coupling constants. The model predicts the mass of the neutral $ρ^0$-meson to be about $1\,MeV$ larger than the mass of the charged mesons $ρ^{\pm}$. The vector $ω$-meson, which is a sterile particle with respect to the considered gauge group $SU_I(2)\times U_Y(1)$, can be added to the scheme by means of a gauge-invariant operator of dimension 5, as shown in Appendix ~A.
description: 14 pages, 6 figures, accepted for publication in Commun. Theor. Phys
Transcriptome and long noncoding RNA sequencing of three extracellular vesicle subtypes released from the human colon cancer LIM1863 cell line
Creators: name: Chen, Maoshan
name: Xu, Rong
name: Ji, H
name: Greening, David
name: Rai, A
name: Izumikawa, K
name: Ishikawa, H
name: Takahashi, N
name: Simpson, Richard
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Previously we reported that LIM1863 colorectal cancer (CRC) cells secrete three distinct extracellular vesicle subtypes-two subpopulations of exosomes (apical EpCAM-Exos and basolateral A33-Exos) and shed microvesicles (sMVs)-with distinct protein and miRNA signatures. Here, we extend our omics approach to understand the fundamental role of LIM1863-derived EVs by performing a comprehensive analysis of their mRNAs and long non-coding RNAs (lncRNAs) using RNA-Seq. We show that 2,389 mRNAs, 317 pseudogene transcripts, 1,028 lncRNAs and 206 short non-coding RNAs selectively distributed to (i.e., are enriched in) LIM1863 EVs, relative to the parent cell. An Ensembl/UniProtKB analysis revealed 1,937 mRNAs encode canonical proteins, 348 isoforms (including splice-variant proteins), and 119 'missing proteins' (i.e., annotated in Ensembl but not UniProtKB). Further dissection of our protein/RNA data revealed that 6/151 observed RNA binding proteins have the potential to interact with ∼75% of EV-enriched RNAs. Intriguingly, the co-existence of U1 and U2 ribonucleoproteins and their cognate snRNAs in LIM1863 EVs suggests a possible association of CRC EVs with recipient cell splicing events. Our data reveal several potential lncRNA CRC biomarkers and novel splicing/fusion genes that, collectively, will advance our understanding of EV biology in CRC and accelerate the development of EV-based diagnostics and therapeutics.
S-nitrosylation and S-glutathionylation of Cys134 on troponin I have opposing competitive actions on Ca2+ sensitivity in rat fast-twitch muscle fibers
Creators: name: Dutka, Travis
name: Mollica, JP
name: Lamboley, CR
name: Weerakkody, VC
name: Greening, David
name: Posterino, Giuseppe
name: Murphy, Robyn
name: Lamb, Graham
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Nitric oxide is generated in skeletal muscle with activity and decreases Ca2+ sensitivity of the contractile apparatus, putatively by S-nitrosylation of an unidentified protein. We investigated the mechanistic basis of this effect and its relationship to the oxidation-induced increase in Ca2+ sensitivity in mammalian fast-twitch (FT) fibers mediated by S-glutathionylation of Cys134 on fast troponin I (TnIf). Force-[Ca2+] characteristics of the contractile apparatus in mechanically skinned fibers were assessed by direct activation with heavily Ca2+-buffered solutions. Treatment with S-nitrosylating agents, S-nitrosoglutathione (GSNO) or S-nitroso-N-acetyl-penicillamine (SNAP), decreased pCa50 ( = −log10 [Ca2+] at half-maximal activation) by ~-0.07 pCa units in rat and human FT fibers without affecting maximum force, but had no effect on rat and human slow-twitch fibers or toad or chicken FT fibers, which all lack Cys134. The Ca2+ sensitivity decrease was 1) fully reversed with dithiothreitol or reduced glutathione, 2) at least partially reversed with ascorbate, indicative of involvement of S-nitrosylation, and 3) irreversibly blocked by low concentration of the alkylating agent, N-ethylmaleimide (NEM). The biotin-switch assay showed that both GSNO and SNAP treatments caused S-nitrosylation of TnIf. S-glutathionylation pretreatment blocked the effects of S-nitrosylation on Ca2+ sensitivity, and vice-versa. S-nitrosylation pretreatment prevented NEM from irreversibly blocking S-glutathionylation of TnIf and its effects on Ca2+ sensitivity, and likewise S-glutathionylation pretreatment prevented NEM block of S-nitrosylation. Following substitution of TnIf into rat slow-twitch fibers, S-nitrosylation treatment caused decreased Ca2+ sensitivity. These findings demonstrate that S-nitrosylation and S-glutathionylation exert opposing effects on Ca2+ sensitivity in mammalian FT muscle fibers, mediated by competitive actions on Cys134 of TnIf.
Transient asymptotics of the modified Camassa-Holm equation
Creators: name: Xu, Taiyang
name: Yang, Yiling
name: Zhang, Lun
Publisher: name: arXiv
Year: 2023
Subjects: subject: Analysis of PDEs (math.AP)
subject: Mathematical Physics (math-ph)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 35Q53, 37K15, 34M50, 35Q15, 35B40, 37K40, 33E17, 34M55

description: We investigate long time asymptotics of the modified Camassa-Holm equation in three transition zones under a nonzero background. The first transition zone lies between the soliton region and the first oscillatory region, the second one lies between the second oscillatory region and the fast decay region, and possibly, the third one, namely, the collisionless shock region, that bridges the first transition region and the first oscillatory region. Under a low regularity condition on the initial data, we obtain Painlevé-type asymptotic formulas in the first two transition regions, while the transient asymptotics in the third region involves the Jacobi theta function. We establish our results by performing a $\bar{\partial}$ nonlinear steepest descent analysis to the associated Riemann-Hilbert problem.
description: 58 pages, 16 figures. Minor corrections for 2nd version according to anonymous referees' comments. To appear in Journal of the London Mathematical Society
Developing polygenic risk models with rich full medical profiles
Creators: name: Laur, Sven
Publisher: name: Zenodo
Year: 2024
Subjects: subject: Machine learning
subject: Data science
subject: Medical genetics
subject: Computer and information sciences
subject: FOS: Computer and information sciences

description: Short description of results obtained in ESR 8. Describes a progress in development of risk models for polygenic diseases.
BioExcel Webinar #8 - Large-scale analytical workflows on the cloud using Galaxy and Globus
Creators: name: Madduri, Ravi
Publisher: name: Zenodo
Year: 2016
Subjects: webinar

description: In this BioExcel webinar we are delighted to have Ravi Madduri from Argonne National Laboratory and University of Chicago present Globus Genomics, a system developed for rapid analysis of large quantities of next-generation sequencing (NGS) genomic data, combining Galaxy workflows with cloud technologies like Amazon EC2 and Globus File Transfer. This system achieves a high degree of end-to-end automation that encompasses every stage of data analysis including initial data retrieval from remote sequencing centers or storage (via the Globus file transfer system); specification, configuration, and reuse of multi-step processing pipelines (via the Galaxy workflow system); creation of custom Amazon Machine Images and on-demand resource acquisition via a specialized elastic provisioner (on Amazon EC2); and efficient scheduling of these pipelines over many processors (via the HTCondor scheduler). The system allows biomedical researchers to perform rapid analysis of large NGS datasets in a fully automated manner, without software installation or a need for any local computing infrastructure. Ravi’s work is part of the BD2K center Big Data for Discovery Science, building infrastructure for reproducible workflows using minids (minimal viable identifiers), analyzing data at scale using identified Docker containers, publish results in to Globus Publication services thus providing an end-to-end framework for reproducible research. In this BioExcel webinar, Ravi will present Globus Genomics and the technologies used to achieve large-scale analytical Galaxy workflows on the cloud. We think this will be of interest not just for the genomics community, but for any scientific workflow users who need to consider distributed deployments, data management and scalability.
Applications of Automatic Writing Evaluation to Guide the Understanding of Learning and Teaching
Creators: name: Vitartas, Peter
name: Heath, James
name: Midford, Sarah
name: Ong, Kok-Leong
name: Alahakoon, Damminda
name: Sullivan Mort, Gillian
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 39
subject: Education
classificationCode: 3904
subject: Specialist studies in education

description: This paper provides an overview of tools and approaches to Automated Writing Evaluation (AWE). It provides a summary of the two emerging disciplines in learning analytics then outlines two approaches used in text analytics. A number of tools currently available for AWE are discussed and the issues of validity and reliability of AWE tools examined. We then provide details of three areas where the future direction for AWE look promising and have been identified in the literature. These areas include opportunities for large-scale marking, their use in MOOCs and in formative feedback for students. We introduce a fourth opportunity previously not widely canvased; where learning analytics can be used to guide teachers’ insights to provide assistance to students based on an analysis of the assignment corpus and to support moderation between markers. We conclude with brief details of a project exploring these insights being undertaken at an Australian institution.
SynthoGestures: A Novel Framework for Synthetic Dynamic Hand Gesture Generation for Driving Scenarios
Creators: name: Gomaa, Amr
name: Zitt, Robin
name: Reyes, Guillermo
name: Krüger, Antonio
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Artificial Intelligence (cs.AI)
subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: Creating a diverse and comprehensive dataset of hand gestures for dynamic human-machine interfaces in the automotive domain can be challenging and time-consuming. To overcome this challenge, we propose using synthetic gesture datasets generated by virtual 3D models. Our framework utilizes Unreal Engine to synthesize realistic hand gestures, offering customization options and reducing the risk of overfitting. Multiple variants, including gesture speed, performance, and hand shape, are generated to improve generalizability. In addition, we simulate different camera locations and types, such as RGB, infrared, and depth cameras, without incurring additional time and cost to obtain these cameras. Experimental results demonstrate that our proposed framework, SynthoGestures (https://github.com/amrgomaaelhady/SynthoGestures), improves gesture recognition accuracy and can replace or augment real-hand datasets. By saving time and effort in the creation of the data set, our tool accelerates the development of gesture recognition systems for automotive applications.
description: Accepted at IEEE IV'24. Shorter versions were accepted as AutomotiveUI2023 Work in Progress and UIST2023 Poster Papers
Three-dimensional GRMHD Simulations of Rapidly Rotating Stellar Core-Collapse
Creators: name: Shibagaki, Shota
name: Kuroda, Takami
name: Kotake, Kei
name: Takiwaki, Tomoya
name: Fischer, Tobias
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present results from fully general relativistic (GR), three-dimensional (3D), neutrino-radiation magneto-hydrodynamic (MHD) simulations of stellar core collapse of a 20 M$_\odot$ star with spectral neutrino transport. Our focus is to study the gravitational-wave (GW) signatures from the magnetorotationally (MR)-driven models. By parametrically changing the initial angular velocity and the strength of the magnetic fields in the core, we compute four models. Our results show that the MHD outflows are produced only for models (two out of four), to which magnetic field strengths of 10$^{12}$ G and rotation rates of 1 or 2 rad s$^{-1}$ are initially imposed in the core. Seen from the direction perpendicular to the rotational axis, a characteristic waveform is obtained exhibiting a monotonic time increase in the wave amplitude. As previously identified, this stems from the propagating MHD outflows along the axis. We show that the GW amplitude from anisotropic neutrino emission becomes more than one order-of-magnitude bigger than that from the matter contribution, whereas seen from the rotational axis, both of the two components are in the same order-of-magnitudes. Due to the memory effect, the frequency of the neutrino GW from our full-fledged 3D-MHD models is in the range less than $\sim$10 Hz. Toward the future GW detection for a Galactic core-collapse supernova, if driven by the MR mechanism, the planned next-generation detector as DECIGO is urgently needed to catch the low-frequency signals.
description: 12 pages, 10 figures
A Family of Pretrained Transformer Language Models for Russian
Creators: name: Zmitrovich, Dmitry
name: Abramov, Alexander
name: Kalmykov, Andrey
name: Tikhonova, Maria
name: Taktasheva, Ekaterina
name: Astafurov, Danil
name: Baushenko, Mark
name: Snegirev, Artem
name: Kadulin, Vitalii
name: Markov, Sergey
name: Shavrina, Tatiana
name: Mikhailov, Vladislav
name: Fenogenova, Alena
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences

description: Transformer language models (LMs) are fundamental to NLP research methodologies and applications in various languages. However, developing such models specifically for the Russian language has received little attention. This paper introduces a collection of 13 Russian Transformer LMs, which spans encoder (ruBERT, ruRoBERTa, ruELECTRA), decoder (ruGPT-3), and encoder-decoder (ruT5, FRED-T5) architectures. We provide a report on the model architecture design and pretraining, and the results of evaluating their generalization abilities on Russian language understanding and generation datasets and benchmarks. By pretraining and releasing these specialized Transformer LMs, we aim to broaden the scope of the NLP research directions and enable the development of industrial solutions for the Russian language.
description: LREC-COLING-2024
The targum (1920:Nov. 2 - 1920:Nov. 23)
Creators: name: No Name Supplied
Publisher: name: Targum Association
Year: 1920

description: Some University historians indicate that the Targum was first published as an annual in 1867, but of this we have no extant evidence. In January 1869, the Targum as we now know it, made its appearance as a monthly paper that concerned itself with student “literary contributions” and college news as well as serving as a vehicle for bringing news to alumni and the general public. The newspaper, which originally was for sale, varied in frequency over the years as did its title (The Targum, Rutgers Targum, Rutgers Daily Targum, and Daily Targum). The newspaper has continuously been published since 1869 with the exception of 19 months during the second world war, between February 1944 and October 1945. The Targum was published by the students of Rutgers College, and later Rutgers University—New Brunswick represented through the years as the Targum Association, Rutgers Targum Association, and Rutgers College Targum. As a student organization, the Targum operated under the oversight of the dean of students and student government but in October 1980, the Targum became an independent college paper.
Extracellular vesicles: their role in cancer biology and epithelial-mesenchymal transition
Creators: name: Krishnan, Shashi Kumar Shashi Gopal
name: Greening, David
name: Rai, Alin
name: Chen, Maoshan
name: Xu, Rong
name: Shafiq, Adnan
name: Mathias, Rommel A
name: Zhu, HJ
name: Simpson, Richard
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3101
subject: Biochemistry and cell biology

description: Cell-cell communication is critical across an assortment of physiological and pathological processes. Extracellular vesicles (EVs) represent an integral facet of intercellular communication largely through the transfer of functional cargo such as proteins, messenger RNAs (mRNAs), microRNA (miRNAs), DNAs and lipids. EVs, especially exosomes and shed microvesicles, represent an important delivery medium in the tumour micro-environment through the reciprocal dissemination of signals between cancer and resident stromal cells to facilitate tumorigenesis and metastasis. An important step of the metastatic cascade is the reprogramming of cancer cells from an epithelial to mesenchymal phenotype (epithelial-mesenchymal transition, EMT), which is associated with increased aggressiveness, invasiveness and metastatic potential. There is now increasing evidence demonstrating that EVs released by cells undergoing EMT are reprogrammed (protein and RNA content) during this process. This review summarises current knowledge of EV-mediated functional transfer of proteins and RNA species (mRNA, miRNA, long non-coding RNA) between cells in cancer biology and the EMT process. An in-depth understanding of EVs associated with EMT, with emphasis on molecular composition (proteins and RNA species), will provide fundamental insights into cancer biology.
Extracellular vesicles: their role in cancer biology and epithelial-mesenchymal transition
Creators: name: Krishnan, Shashi Kumar Shashi Gopal
name: Greening, David
name: Rai, Alin
name: Chen, Maoshan
name: Xu, Rong
name: Shafiq, Adnan
name: Mathias, Rommel A
name: Zhu, HJ
name: Simpson, Richard
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: Cell-cell communication is critical across an assortment of physiological and pathological processes. Extracellular vesicles (EVs) represent an integral facet of intercellular communication largely through the transfer of functional cargo such as proteins, messenger RNAs (mRNAs), microRNA (miRNAs), DNAs and lipids. EVs, especially exosomes and shed microvesicles, represent an important delivery medium in the tumour micro-environment through the reciprocal dissemination of signals between cancer and resident stromal cells to facilitate tumorigenesis and metastasis. An important step of the metastatic cascade is the reprogramming of cancer cells from an epithelial to mesenchymal phenotype (epithelial-mesenchymal transition, EMT), which is associated with increased aggressiveness, invasiveness and metastatic potential. There is now increasing evidence demonstrating that EVs released by cells undergoing EMT are reprogrammed (protein and RNA content) during this process. This review summarises current knowledge of EV-mediated functional transfer of proteins and RNA species (mRNA, miRNA, long non-coding RNA) between cells in cancer biology and the EMT process. An in-depth understanding of EVs associated with EMT, with emphasis on molecular composition (proteins and RNA species), will provide fundamental insights into cancer biology.
Dodging the Communications Decency Act when Analyzing Libel Liability of On-line Services
Creators: name: Fried, Neil
Publisher: name: Science and Technology Law Review
Year: 1999

description: Dodging the Communications Decency Act when Analyzing Libel Liability of On-line Services discusses the on-line libel case of Lunney v. Prodigy. In that case, the Appellate Division of the N.Y. Supreme Court treated Prodigy like a common carrier rather than apply provisions of the Communication Decency Act that prohibit treating interactive computer services as publishers of third-party speech. The court appears to have done so to avoid reaching issues regarding retroactive application of the CDA. The article discusses the Appellate Division’s analysis, and concludes that the court’s decision to sidestep the CDA and to compare service providers to common carriers was unwise. In the process, the article addresses four seminal on-line libel cases—Cubby, Inc. v. CompuServe, Inc.; Stratton Oakmont, Inc. v. Prodigy Servs. Co.; Zeran v. America Online, Inc.; and Blumenthal v. Drudge—as well as the libel-related provisions of the CDA. Lastly, the article makes recommendations to the N.Y. Court of Appeals, which heard oral arguments October 13, 1999, in an appeal of the case.
description: Science and Technology Law Review, Vol 1: 1999-2000
Sexually active older Australian's knowledge of sexually transmitted infections and safer sexual practices
Creators: name: Lyons, Anthony
name: Heywood, Wendy
name: Fileborn, Bianca
name: Minichiello, Victor
name: Barrett, Catherine
name: Brown, Graham
name: Hinchliff, Sharron
name: Malta, Sue
name: Crameri, Pauline
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4202
subject: Epidemiology
classificationCode: 4203
subject: Health services and systems
classificationCode: 4206
subject: Public health

description: Objective: Rates of sexually transmitted infections (STIs) are rising among older Australians. We conducted a large survey of older people's knowledge of STIs and safer sexual practices. Methods: A total of 2,137 Australians aged 60 years and older completed the survey, which included 15 questions assessing knowledge of STIs and safer sexual practices. We examined both levels of knowledge and factors associated with an overall knowledge score. Results: In total, 1,652 respondents reported having sex in the past five years and answered all knowledge questions. This group had good general knowledge but poorer knowledge in areas such as the protection offered by condoms and potential transmission modes for specific STIs. Women had better knowledge than men. Men in their 60s, men with higher education levels, and men who thought they were at risk of STIs reported better knowledge than other men. Knowledge was also better among men and women who had been tested for STIs or reported ‘other’ sources of knowledge on STIs. Conclusions: Many older Australians lack knowledge of STIs and safer sexual practices. Implications for public health: To reverse current trends toward increasing STI diagnoses in this population, policies and education campaigns aimed at improving knowledge levels may need to be considered.
When Efforts To Conceal May Actually Reveal
Creators: name: Dixon, Rod
Publisher: name: Science and Technology Law Review
Year: 2000

description: When Efforts To Conceal May Actually Reveal challenges the application of traditional copyright doctrine to computer source code. A recent decision by the Court of Appeals for the Ninth Circuit–upholding the proposition that computer source code is speech–provides a constitutional basis for reassessing the limiting principles of copyright law in the context of digital technologies. A First Amendment analysis of source code, the author contends, illuminates the failure of copyright doctrine (applying the so-called idea/expression dichotomy) to adequately calibrate the boundaries of copyright and free speech. Supporting his theoretical arguments for limiting the scope of copyright protection, the author identifies a growing movement within the computer programming community in favor of free and open access to source code. Weighing, among other things, the public policy goals underlying copyright and free speech law, the author concludes that source code should rarely be regarded as a category of expression created as a result of independent, and hence, original authorship.
description: Science and Technology Law Review, Vol 1: 1999-2000
Privatization and Commercialization of the Internet Infrastructure
Creators: name: Frischmann, Brett
Publisher: name: Science and Technology Law Review
Year: 2001

description: This article analyzes the following general question: Will the full range of end-users be adequately supplied with the Internet in the long-term to satisfy their particular end-uses if the Internet infrastructure remains privatized and commercialized? In other words, if the Internet infrastructure is a necessary input for producing various public and private goods (i.e., in facilitating different end-uses), will procurement and commercial markets adequately supply society with Internet infrastructure? The article begins with a brief, descriptive account of the establishment, management, and eventual privatization, commercialization, and decommissioning of NSFNET, the precursor of today’s Internet. Then, it develops and applies an economic model of Internet infrastructure to assess both the past and the future of the Internet, focusing primarily on the Internet’s interconnection infrastructure.The article also explores the synergistic role of the Internet and individuals in the production of public goods.
description: Science and Technology Law Review, Vol 2: 2000-2001
Rubin, M., & Hewstone, M. (1998). Social identity theory’s self-esteem hypothesis: A review and some suggestions for clarification. Personality and Social Psychology Review, 2, 40-62. doi: 10.1207/s15327957pspr0201_3
Creators: name: Rubin, Mark
Publisher: name: figshare
Year: 2013
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Distinctions are made between global and specific, personal and social, and trait and state self-esteem, and these are used to structure a review of over 40 studies concerning social identity theory's hypothesis.
Voci, A., Hewstone, M., Crisp, R. J., & Rubin, M. (2008). Majority, minority, and parity: Effects of gender and group size on perceived group variability. Social Psychology Quarterly, 71, 114-142. doi: 10.1177/019027250807100203
Creators: name: Rubin, Mark
Publisher: name: figshare
Year: 2013
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: We investigated the effects of gender and group size on perceptions of group variability, using groups of students taking different majors that varied in the proportion of men and women (female-majority, parity, and male-majority).
Going for the Blue Ribbon
Creators: name: Fisher, Michael
Publisher: name: Science and Technology Law Review
Year: 2001

description: In “Going for the Blue Ribbon: the Legality of Expert Juries in Patent Litigation”, the author discusses the legality and practicality of employing “blue ribbon” – i.e. expert – juries in certain patent litigation. The use of such juries, it is argued, would reduce the arbitrariness of and restore fairness to the adjudicative process in light of the complex technical and scientific issues frequently encountered in patent litigation. The author demonstrates how these special juries would resolve the tension between two competing constitutional guarantees: the right to a trial by jury, under the Seventh Amendment, and the right to due process (and a minimum level of juror competency implied by such right), under the Fifth Amendment. It is even suggested that there may be a constitutional obligation to provide a sufficiently skilled jury in patent cases. The note then addresses potential legal barriers to blue ribbon juries – particularly the “fair cross section requirement” for juries under the Equal Protection Clause – and presents case-law and demographic evidence demonstrating how these barriers could be overcome. Finally, the author examines the practical considerations of employing blue ribbon juries, concluding that the federal court system could accommodate such a measure through its existing infrastructure, and that sufficient jurors could be obtained from society’s pool of “experts”.
description: Science and Technology Law Review, Vol 2: 2000-2001
Due Process and In Rem Jurisdiction under the Anti-Cybersquatting Consumer Protection Act
Creators: name: Grotto, Andrew
Publisher: name: Science and Technology Law Review
Year: 2001

description: The 1999 enactment of the Anti-Cybersquatting Consumer Protection Act (ACPA) provides trademark holders with effective and efficient means to defend their marks against bad faith cybersquatters. The statute’s in rem jurisdiction provisions, whereby the infringing domain name stands as the res and its situs is deemed to be the jurisdiction hosting the domain name registrar, are one of its more powerful features, enabling trademark owners to sue foreign or anonymous cybersquatters. However, the constitutional status of in rem jurisdiction is uncertain, as the Supreme Court has been unable to agree on the extent of contacts needed to establish in rem jurisdiction. So far, the ACPA in rem provisions have withstood constitutional due process challenges, but the leading case was not thorough enough in its due process analysis. By focusing on the particular manner in which the ACPA in rem jurisdiction provisions impact a cybersquatter’s rights, the author argues that the ACPA in rem provisions do not run afoul of due process. The novelty of a domain name standing as a res isolates the ACPA from conventional in rem caselaw. However, the author points out that while the constitutional status of in rem jurisdiction is unsettled, maritime caselaw provides some guidance on the due process requirements for the ACPA provisions. The author proceeds to argue, on the basis of these guidelines, that the ACPA contains procedural safeguards that strongly support constitutionality. The author then shows how certain indicia of cybersquatter bad faith may provide additional contacts to buttress the procedural safeguards. The procedural safeguards, together with the additional contacts supplied by bad faith, assure that the operation of the ACPA in rem jurisdiction provisions complies with due process.
description: Science and Technology Law Review, Vol 2: 2000-2001
Extraction of the neutron F2 structure function from inclusive proton and deuteron deep-inelastic scattering data
Creators: name: Li, Shujie
name: Accardi, Alberto
name: Cerutti, Matteo
name: Fernando, Ishara. P.
name: Keppel, Cynthia E.
name: Melnitchouk, Wally
name: Monaghan, Peter
name: Niculescu, Gabriel
name: Niculescu, Maria I.
name: Owens, Jeff. F.
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Experiment (nucl-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The available world deep-inelastic scattering data on proton and deuteron structure functions F2p, F2d, and their ratios, are leveraged to extract the free neutron F2n structure function, the F2n/F2p ratio, and associated uncertainties using the latest nuclear effect calculations in the deuteron. Special attention is devoted to the normalization of the proton and deuteron experimental datasets and to the treatment of correlated systematic errors, as well as the quantification of procedural and theoretical uncertainties. The extracted F2n dataset is utilized to evaluate the Q2 dependence of the Gottfried sum rule and the nonsinglet F2p - F2n moments. To facilitate replication of our study, as well as for general applications, a comprehensive DIS database including all recent JLab 6 GeV measurements, the extracted F2n, a modified CTEQ-JLab global PDF fit named CJ15nlo_mod, and grids with calculated proton, neutron and deuteron DIS structure functions at next-to-leading order, are discussed and made publicly available.
description: 55 pages. Database: https://www.jlab.org/theory/cj, https://github.com/JeffersonLab/CJ-database
Rubin, M., & Badea, C. (2012). They’re all the same!...but for several different reasons: A review of the multicausal nature of perceived group variability. Current Directions in Psychological Science, 21, 367-372. doi: 10.1177/0963721412457363
Creators: name: Rubin, Mark
Publisher: name: figshare
Year: 2013
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Perceived group variability refers to the variability that people perceive among the members of a social group. Researchers in this area have tended to focus on the way in which perceivers’ group affiliations lead to in-group and out-group homogeneity effects, including the other race effect.
DR5 and caspase-8 are dispensable in ER stress-induced apoptosis
Creators: name: Glab, Jason
name: Doerflinger, Marcel
name: Nedeva, Christina
name: Jose, Irvin
name: Mbogo, George W
name: Paton, James C
name: Paton, Adrienne W
name: Kueh, Andrew J
name: Herold, Marco
name: Huang, David CS
name: Segal, David
name: Brumatti, Gabriella
name: Puthalakath, Hamsa
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3101
subject: Biochemistry and cell biology
classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences

description: No description supplied
Towards 6D Little String Theory of Particles
Creators: name: Raitio, Risto
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: A model for particles based on preons in chiral, vector and tensor/graviton supermultiplets of unbroken global supersymmetry is engineered. The framework of the model is little string theory. Phenomenological predictions are discussed.
description: v2. Major upgrade, unfortunate errors in tables 1 and 2 corrected, text compactified. v3. 18 pages, 6 tables, 1 figure. Little string theory framework introduced. Title changed accordingly. v4. Minor changes. JHEPGC in press. arXiv admin note: text overlap with arXiv:1710.05568, arXiv:1511.05565, arXiv:hep-th/9711059 by other authors
Flux-pulse-assisted Readout of a Fluxonium Qubit
Creators: name: Stefanski, Taryn V.
name: Andersen, Christian Kraglund
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Much attention has focused on the transmon architecture for large-scale superconducting quantum devices, however, the fluxonium qubit has emerged as a possible successor. With a shunting inductor in parallel to a Josephson junction, the fluxonium offers larger anharmonicity and stronger protection against dielectric loss, leading to higher coherence times as compared to conventional transmon qubits. The interplay between the inductive and Josephson energy potentials of the fluxonium qubit leads to a rich dispersive shift landscape when tuning the external flux. Here we propose to exploit the features in the dispersive shift to improve qubit readout. Specifically, we report on theoretical simulations showing improved readout times and error rates by performing the readout at a flux bias point with large dispersive shift. We expand the scheme to include different error channels, and show that with an integration time of 155 ns, flux-pulse-assisted readout offers about 5 times improvement in the signal to noise ratio. Moreover, we show that the performance improvement persists in the presence of finite measurement efficiency combined with quasi-static flux noise, and also when considering the increased Purcell rate at the flux-pulse-assisted readout point. We suggest a set of reasonable energy parameters for the fluxonium architecture that will allow for the implementation of our proposed flux-pulse-assisted readout scheme.
description: 11 pages, 7 figures
Rubin, M., Watt, S. E., & Ramelli, M. (2012). Immigrants’ social integration as a function of approach-avoidance orientation and problem-solving style. International Journal of Intercultural Relations, 36, 498-505. doi: 10.1016/j.ijintrel.2011.12.009
Creators: name: Rubin, Mark
Publisher: name: figshare
Year: 2013
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Rubin, M., Watt, S. E., & Ramelli, M. (2012). Immigrants’ social integration as a function of approach-avoidance orientation and problem-solving style. International Journal of Intercultural Relations, 36, 498-505. doi: 10.1016/j.ijintrel.2011.12.009
Rubin, M., & Badea, C. (2007). Why do people perceive in-group homogeneity on in-group traits and out-group homogeneity on out-group traits? Personality and Social Psychology Bulletin, 33, 31-42. doi: 10.1177/0146167206293190
Creators: name: Rubin, Mark
Publisher: name: figshare
Year: 2013
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: People tend to perceive ingroup homogeneity on ingroup stereotypical traits and outgroup homogeneity on outgroup stereotypical traits (e.g., Kelly, 1989; Simon, 1992a; Simon & Pettigrew, 1990).
Rubin, M., & Badea, C. (2010). The central tendency of a social group can affect ratings of its intragroup variability in the absence of social identity concerns. Journal of Experimental Social Psychology, 46, 410-415. doi: 10.1016/j.jesp.2010.01.001
Creators: name: Rubin, Mark
Publisher: name: figshare
Year: 2013
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: People report less variability within in‑groups than within out‑groups when they make their ratings on traits on which the in‑group has a higher central tendency than the out‑group.
Evanescently coupled topological ring-waveguide systems for chip-scale ultrahigh frequency phononic circuits
Creators: name: Hatanaka, Daiki
name: Takeshita, Hiroaki
name: Kataoka, Motoki
name: Okamoto, Hajime
name: Tsuruta, Kenji
name: Yamaguchi, Hiroshi
Publisher: name: arXiv
Year: 2023
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Topological phononics enabling backscattering-immune transport is expected to improve the performance of electromechanical systems for classical and quantum information technologies. Nonetheless, most of the previous demonstrations utilized macroscale and low-frequency structures and thus offered little experimental insight into ultrahigh frequency phonon transport, especially in chip-scale circuits. Here, we report microwave phonon transmissions in a microscopic topological ring-waveguide coupled system, which is an important building block for wave-based signal processing. The elastic waves in the topological waveguide evanescently couple to the ring resonator, while maintaining the valley pseudospin polarization. The resultant waves are robust to backscattering even in the tiny hexagonal ring, generating a resonant phonon circulation. Furthermore, the evanescently coupled structure allows for a critical coupling, where valley-dependent ring-waveguide interference enables blocking of the topological edge transmission. Our demonstrations reveal the capability of using topological phenomena to manipulate ultrahigh frequency elastic waves in intricate phononic circuits for classical and quantum signal-processing applications.
description: 13 pages, 9 figures
DR5 and caspase-8 are dispensable in ER stress-induced apoptosis
Creators: name: Glab, Jason
name: Doerflinger, Marcel
name: Nedeva, Christina
name: Jose, Irvin
name: Mbogo, George W
name: Paton, James C
name: Paton, Adrienne W
name: Kueh, Andrew J
name: Herold, Marco J
name: Huang, David CS
name: Segal, David
name: Brumatti, Gabriella
name: Puthalakath, Hamsa
Publisher: name: La Trobe
Year: 2022

description: No description supplied
A simple linear algebra identity to optimize Large-Scale Neural Network Quantum States
Creators: name: Rende, Riccardo
name: Viteritti, Luciano Loris
name: Bardone, Lorenzo
name: Becca, Federico
name: Goldt, Sebastian
Publisher: name: arXiv
Year: 2023
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: Neural-network architectures have been increasingly used to represent quantum many-body wave functions. These networks require a large number of variational parameters and are challenging to optimize using traditional methods, as gradient descent. Stochastic Reconfiguration (SR) has been effective with a limited number of parameters, but becomes impractical beyond a few thousand parameters. Here, we leverage a simple linear algebra identity to show that SR can be employed even in the deep learning scenario. We demonstrate the effectiveness of our method by optimizing a Deep Transformer architecture with $3 \times 10^5$ parameters, achieving state-of-the-art ground-state energy in the $J_1$-$J_2$ Heisenberg model at $J_2/J_1=0.5$ on the $10\times10$ square lattice, a challenging benchmark in highly-frustrated magnetism. This work marks a significant step forward in the scalability and efficiency of SR for Neural-Network Quantum States, making them a promising method to investigate unknown quantum phases of matter, where other methods struggle.
description: 7 pages, 4 figure and 1 table
Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress
Creators: name: Dinh, Quynh Nhu
name: Drummond, Grant
name: Kemp-Harper, Barbara K
name: Diep, Henry
name: De Silva, Michael
name: Kim, Hyun Ah
name: Vinh, Antony
name: Robertson, Avril AB
name: Cooper, Matthew A
name: Mansell, Ashley
name: Chrissobolis, Sophocles
name: Sobey, Christopher
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 3101
subject: Biochemistry and cell biology
classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences

description: Aging is commonly associated with chronic low-grade inflammation and hypertension but it is unknown whether a cause-effect relationship exists between them. We compared the sensitivity of young adult (8-12 w) and aged (23-31 mo) male C57Bl6J mice to develop hypertension in response to a slow-pressor dose of angiotensin II (Ang II; 0.28 mg/kg/d; 28 d). In young mice, the pressor response to Ang II was gradual and increased to 142±8 mmHg over 28 d. However, in aged mice, Ang II promptly increased SBP and reached 155±12 mmHg by 28 d. Aging increased renal but not brain expression of Ang II receptors (At1ar and At2r) and elevated AT1R:AT2R expression ratio in mesenteric artery. Maximal contractile responses of mesenteric arteries to Ang II were enhanced in aged mice and were not affected by L-NAME, indomethacin or tempol. Mesenteric arteries and thoracic aortae from aged mice exhibited higher Nox2-dependent superoxide production. Despite having higher renal expression of Nlrp3, Casp-1 and Il-1β, Ang II-induced hypertension (SBP: 139±7 mmHg) was unaffected by co-infusion of the NLRP3 inflammasome inhibitor, MCC950 (10 mg/kg/d; SBP: 145±10 mmHg). Thus, increased vascular AT1R:AT2R expression, rather than NLRP3 inflammasome activation, may contribute to enhanced responses to Ang II in aging.