Additional file 1 of APOE effects on regional tau in preclinical Alzheimer’s disease
Creators: name: Young, Christina B.
name: Johns, Emily
name: Kennedy, Gabriel
name: Belloy, Michael E.
name: Insel, Philip S.
name: Greicius, Michael D.
name: Sperling, Reisa A.
name: Johnson, Keith A.
name: Poston, Kathleen L.
name: Mormino, Elizabeth C.
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Neuroscience
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Supplementary Methods. Description of how amyloid SUVRs are converted to centiloids. Table S1. Demographic information for the 392 Aβ+ CU individuals with tau PET imaging from A4/LEARN. Table S2. Association between amyloid burden (centiloids) and regional tau SUVRs in (A) Aβ- and Aβ+ participants and in (B) only Aβ+ participants from A4/LEARN. Unstandardized beta values (SE), p-values, and model R2 values are listed. Each column represents a separate regression model. Table S3.APOE associations with regional tau SUVRs in 392 Aβ+s with APOE*Age and APOE*Sex interactions included in the model. Unstandardized beta values (SE) and p-values are listed. Each column represents a separate regression model. Table S4. (A) APOE associations with regional tau SUVRs in 359 Aβ+ individuals (B) with APOE*age and APOE*sex interactions after excluding APOE homozygotes (1 e2/e2 participant and 25 e4/e4 participants). Unstandardized beta values (SE) and p-values are listed. Each column represents a separate regression model. Table S5. (A) APOE associations with regional tau SUVRs in 372 Aβ+ individuals (B) with APOE*age and APOE*sex interactions after excluding 13 e2/e4 participants. Unstandardized beta values (SE) and p-values are listed. Each column represents a separate regression model. Table S6. Comparisons of regional tau SUVRs between APOE (A) e2/e3 and e3/e3 groups as well as (B) e3/e4 and e3/e3 groups after adjusting for age and sex. Unstandardized beta values (SE) and p-values are listed. Each column represents a separate regression model. Figure S1. Conversion of global SUVRs to centiloids (CL). (A) Conversion of florbetapir (FBP) global amyloid SUVRs to CLs for A4/LEARN data. (B) Conversion of FBP and florbetaben (FBB) global amyloid SUVRs to CLs for ADNI data. (C) CL distributions across A4/LEARN FBP, ADNI FBP, and ADNI FBB data. Figure S2. Mediation models examining direct and indirect effects of APOE on regional tau SUVRs with continuous amyloid (centiloids) as a mediator in (A) Aβ+ clinically unimpaired (CU) individuals from A4 and (B) Aβ+ CU and mild cognitive impairment (MCI) individuals from ADNI. Both e4 and e2 effects were examined in A4, but only e4 effects were examined in ADNI due to the small sample size of e2 Aβ+ participants in ADNI (n = 13). Unstandardized betas are listed. Note: * p &lt; 0.05, ** p &lt; 0.01, *** p &lt; 0.001. Figure S3. Mediation models examining the effects of APOE4 on regional tau SUVRs with continuous amyloid (centiloids) as a mediator among 162 Aβ+ CU and mild cognitive impairment (MCI) participants who had tau and amyloid PET scans within 2 years of each other. Results are consistent with the effects in the larger ADNI sample. Note: * p &lt; 0.05, ** p &lt; 0.01, *** p &lt; 0.001.