PROTOCOL Adipose Tissue, the Role of Adipokines, and Obesity Metrics: A Bioinformatics-assisted Review [The Project ATA]
Creators: name: Bonilla, Diego A.
Publisher: name: figshare
Year: 2023
Subjects: Public health nutrition
Analytical biochemistry
Biological network analysis
Health management

description: <strong>SIMPLE SUMMARY</strong> <br> Obesity is a complex and multifactorial metabolic disorder considered a public health problem due to its high prevalence worldwide and its relationship with the development of diseases such as type 2 diabetes, cardiovascular disease, and cancer. Adipose tissue (AT) plays a central role in the pathophysiology of obesity and its related comorbidities. Depending on its embryonic origin, location, and/or cellular phenotype, the AT is a heterogeneous tissue able to secrete several molecules (adipokines) with autocrine, paracrine, and endocrine effects on metabolism, inflammation, cell migration, and proliferation, among others. This bioinformatics-assisted review is part of ‘The Project ATA’ (NCT05758311) and presents an integrative approach to i) structural and physiological characteristics of AT types; ii) endocrine function of AT; iii) assessment and diagnostic criteria of obesity; and iv) physical exercise and adipomyokines. <br> <strong>METHODS</strong> <br> A bioinformatics-assisted review (BaR) will be performed following the procedure proposed by Bonilla et al. (2021, 2022). The BaR addresses the lack of systematization in reviews that aim to update and/or analyze phenomena at the molecular level. To overcome subjective and manual time-consuming extraction of information, this approach utilizes experimentally validated, high-level manually curated, and reproducible (open source) data for a given biological phenomenon. This review is conducted as part of ‘The Project ATA’, a multicenter study proposed and currently led by the Research Division of the Dynamical Business and Science Society—DBSS. Experts and researchers in the field will collaborate remotely on the revision of the draft before final approval. <br> <em><strong>Information sources</strong></em> The primary sources for the articles will be the PubMed/MEDLINE, ScienceDirect, and Google Scholar databases. To report functional annotations within the literature review, we will access publicly available databases and repositories: <br> UniProtKB (https://www.uniprot.org/), Protein Data Bank (PDB, https://www.rcsb.org/), the Bi-oGPS–Gene Portal System (http://biogps.org/), and a compendium of 49 tissue-/cell line-wise functional gene networks for humans named TissueNexus (www.diseaselinks.com/TissueNexus/). <br> <em><strong>Search strategy</strong></em> We will perform a search using the free terms “<em>adipose tissue</em>”, “<em>obesity</em>” and “<em>adipokines</em>” to summarize the most recent findings regarding adipose tissue and adipokines. <br> <strong>Findings presentation</strong> The narrative discussion will be aligned with expert interpretation as follows: i) Types of Adipose Tissue; ii) Endocrine Activity of the Adipose Tissue; iii) Diagnosis and risk stratification; and iv) Physical Exercise as a Non-pharmacological intervention and Adipomyokines. <br> <strong>REFERENCES</strong> <br> Bonilla, D. A., Kreider, R. B., Stout, J. R., Forero, D. A., Kerksick, C. M., Roberts, M. D., &amp; Rawson, E. S. (2021). Metabolic Basis of Creatine in Health and Disease: A Bioinformatics-Assisted Review. <em>Nutrients</em>, <em>13</em>(4), 1238. https://doi.org/10.3390/nu13041238 Bonilla, D. A., Moreno, Y., Petro, J. L., Forero, D. A., Vargas-Molina, S., Odriozola-Martínez, A., Orozco, C. A., Stout, J. R., Rawson, E. S., &amp; Kreider, R. B. (2022). A Bioinformatics-Assisted Review on Iron Metabolism and Immune System to Identify Potential Biomarkers of Exercise Stress-Induced Immunosuppression. <em>Biomedicines</em>, <em>10</em>(3), 724. https://doi.org/10.3390/biomedicines10030724 https://clinicaltrials.gov/ct2/show/NCT05758311 https://ichgcp.net/clinical-trials-registry/NCT05758311 <br> <br> <em>Uploaded by the Research Division, Dynamical Business &amp; Science Society — DBSS International SAS, Bogotá 110311, Colombia. E-mail contact: dabonilla@dbss.pro; jlpetro@dbss.pro </em>