cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Molecular mechanisms regulating skeletal muscle homeostasis: effects of V1a AVP receptor over-expression
Creators: name: Scicchitano, Bianca Maria
name: Adamo, Sergio
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2014
Subjects: skeletal muscle; cachexia; regeneration; TNF

description: The maintenance of a working skeletal musculature is conferred by its capacity to regenerate after mechanical or pathological injury. Most muscle pathologies are characterized by the progressive loss of muscle tissue due to chronic degeneration combined with the inability of the regeneration machinery to replace damaged myofibers. Cachexia or muscle wasting is characterized by a loss of adipose and muscle mass associated with a compromised muscle regenerative ability. Arg-vasopressin (AVP) is a potent myogenesis promoting factor and activates both the calcineurin and CaMK pathways, whose combined activation leads to the formation of transcription factor complexes in vitro. The local over-expression of V1a AVP receptor (V1aR) in injured muscle results in enhanced regeneration. V1aR over-expressing muscle exhibits early activation of satellite cells and regeneration markers and accelerated differentiation. Here we investigated the role of V1aR over-expression in animals undergoing cachexia as a result of muscle over-expression of a specific cytokine (TNF). In these conditions, the local V1aR over-expression counteracts the negative effects of cachexia on muscle, as demonstrated by morphological and biochemical analysis. In particular, the presence of V1aR results in increased Pax-7, myogenin and myosin expression levels both in wild type and in cachectic muscles. The positive effects of V1aR on muscle homeostasis are due to the promotion of the calcineurin-IL-4 pathway and to the inhibition of atrophic genes expression mediated by FOXO phosphorylation. This study highlights a novel in vivo role for the AVP-dependent pathways which may suggest a potential gene therapy approach for many diseases affecting muscle homeostasis.
description: Italian Journal of Anatomy and Embryology, Vol 118, No 2 (Supplement) 2013
Interleukin-1 family members in the retina of streptozotocin-injected rats
Creators: name: Scuderi, Soraya
name: D’Amico, Agata Grazia
name: Saccone, Salvatore
name: Bucolo, Claudio
name: Drago, Filippo
name: D’Agata, Velia
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2014

description: Diabetic retinopathy (DR) is one of the most common complications of diabetes. It has been demonstrated that pro-inflammatory cytokines are increased in diabetic retina, including interleukin-1β (IL-1β) (Joussen et al., 2001), suggesting that this cytokine might play an important role in the pathogenesis of DR (Kowluru and Odenbach, 2004). The principal components of the IL-1 family are two secreted factors, IL-1α and IL-1β, two transmembrane receptors (IL-1RI and IL-1RII), and a natural antagonist receptor of IL-1 function (IL-1Ra). To date the molecular mechanisms mediated by IL-1 family members in DR have not been fully characterized. In the present study, to explore the role of IL-1, we analyzed the expression and distribution of IL-1α and IL-1β and relative receptors in a model in vivo of DR. Diabetes was induced in adult rats by intraperitoneal injection of streptozotocin (60 mg/kg). Protein expression and distribution of IL-1 members and relative receptors were analyzed in retinas of nondiabetic and diabetic rats three weeks after induction of diabetes by Western blot and confocal microscopy analyses. Hyperglycemia induced a significant increased in IL-1β protein expression levels and distribution as compared to nondiabetic animals. Specifically, IL-1β retinal immunoreactivity was found not only in the rod and cone layer (RCL), but also in the outer plexiform layer (OPL), inner plexiform (IPL) and in the ganglion cell layer (GCL) of diabetic rats. IL-1α transcription levels were unchanged in the retinas of both animal groups. Consistent with expression studies, IL-1α localization did not differ between diabetic and nondiabetic rats. IL-1RI, IL-1RII and IL-1Ra expression was significantly increased in the retina of diabetic rats when compared to controls. Accordingly, IL-1RI positiveness was thoroughly increased in all retinal layers of diabetic rats, while no evident changes were apparent for IL-1RII, which was localized in the RCL layer and in outer nuclear layer (ONL) of both diabetic and nondiabetic rats. These finding point to IL-1 family members as key elements in the pro-inflammatory cascade after hyperglycemia-induced retinal damage, and therefore support the implementation of novel therapeutic strategies aimed at reducing IL-1 production for the treatment of DR.
description: Italian Journal of Anatomy and Embryology, Vol 118, No 2 (Supplement) 2013
title: Flame Propagation through Ultra-Lean Hydrogen-Air Mixture under Terrestrial Gravity Conditions
Creators: name: Yakovenko, I.
name: Kiverin, A.
name: Melnikova, K.
name: International Seminar On Fire And Explosion Hazards (9; 2019; Saint Petersburg, Russia)
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2019

description: The paper is devoted to the study of peculiarities of flame dynamics in ultra-lean hydrogen-air mixtures in
terrestrial gravity conditions. By means of numerical methods, it is shown that gas-dynamical flows,
which develop due to buoyancy force exerted on hot combustion products, play a crucial role on the
overall ultra-lean flame dynamics from the earliest stage after ignition and up to large-scale motion of the
developed flame. Immediately after ignition convective flows determine the flame kernel stability. It is
shown that despite the superadiabatic temperature of the flame products that is considered as one of the
main stability factors of the ultra-lean flames in microgravity conditions the influence of convective flows
on the ultra-lean flames in terrestrial gravity conditions can alter flammability limits from that measured
in microgravity. On the other hand, the propagation dynamics of the stable flame kernels is also mainly
determined by the buoyancy forces. Rising velocity of the flame kernel in the ultra-lean mixture occurs to
be much greater than burning velocity and correlates well with estimations obtained for the bubble rising
in liquid. Apart from the upward rising, the developed flame is shown to be expanding laterally so the
complex large-scale flame structure is observed which could be a possible hazard of explosion and fire
for many industrial environments.
Nerves and classifying spaces for bicategories
Creators: name: Carrasco, P.
name: Cegarra, A. M.
name: Garzón, A. R.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Algebraic Topology (math.AT)
subject: Category Theory (math.CT)
subject: FOS: Mathematics
subject: 18D05; 55U40

description: This paper explores the relationship amongst the various simplicial and pseudo-simplicial objects characteristically associated to any bicategory C. It proves the fact that the geometric realizations of all of these possible candidate `nerves of C' are homotopy equivalent. Any one of these realizations could therefore be taken as the classifying space BC of the bicategory. Its other major result proves a direct extension of Thomason's `Homotopy Colimit Theorem' to bicategories: When the homotopy colimit construction is carried out on a diagram of spaces obtained by applying the classifying space functor to a diagram of bicategories, the resulting space has the homotopy type of a certain bicategory, called the `Grothendieck construction on the diagram'. Our results provide coherence for all reasonable extensions to bicategories of Quillen's definition of the `classifying space' of a category as the geometric realization of the category's Grothendieck nerve, and they are applied to monoidal (tensor) categories through the elemental `delooping' construction.
description: 42 pages
Stable half-metallic ferromagnetism in nonstoichiometric cubic binary chromium chalcogenides
Creators: name: Guo, San-Dong
name: Liu, Bang-Gui
Publisher: name: arXiv
Year: 2009
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We find that three nonstoichiometric cubic binary chromium chalcogenides, namely Cr3S4, Cr3Se4, and Cr3Te4, are stable half-metallic ferromagnets with wide half-metallic gaps on the basis of systematic state-of-the-arts first-principles calculations. We optimize their structures, and then calculate their magnetic moments, electronic structures, formation heats, and elastic moduli and investigate their structural stability and robustness of ferromagnetism against antiferromagnetic fluctuations. Our calculated results show that the three sulvanite phases are structurally stable and ferromagnetically robust, and hence could be realized as epitaxial thin films. We attribute the structural and ferromagnetic stability and the better half-metallicity to their special effective Cr valence 2.667+. These findings will open doors for much more high-performance spintronic materials compatible with current semiconductor technology.
description: EPL accepted version
title: ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÑÑÑÐºÑÑÑÑ Ð¼ÐµÑ Ð°Ð½Ð¸ÑÐµÑÐºÐ¸ Ð»ÐµÐ³Ð¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÑ Ð¿Ð¾ÑÐ¾ÑÐºÐ¾Ð² Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð¼ÐµÐ´Ð¸
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: ÐÐ°ÑÐºÐ¾Ð²Ð°, ÐÐ°ÑÐ¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: ÐºÐ¾Ð¼Ð¿Ð¾Ð·Ð¸ÑÐ¸Ð¾Ð½Ð½ÑÐ¹ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»
Ð¼ÐµÑ Ð°Ð½Ð¸ÑÐµÑÐºÐ¾Ðµ Ð»ÐµÐ³Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ

description: ÐÐ±ÑÐµÐºÑÐ¾Ð¼ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐ²Ð»ÑÐµÑÑÑ Ð¼ÐµÑÐ°Ð½Ð¸ÑÐµÑÐºÐ¸ Ð»ÐµÐ³Ð¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐ¹ Ð¿Ð¾ÑÐ¾ÑÐ¾Ðº Cu-Ð ÐÐ. ÐÐ¸Ð¿Ð»Ð¾Ð¼Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° ÑÐ¾ÑÑÐ¾Ð¸Ñ Ð¸Ð· Ð²Ð²ÐµÐ´ÐµÐ½Ð¸Ñ, Ð´Ð²ÑÑ Ð³Ð»Ð°Ð² Ð¸ Ð·Ð°ÐºÐ»ÑÑÐµÐ½Ð¸Ñ. ÐÐ¾ Ð²Ð²ÐµÐ´ÐµÐ½Ð¸Ð¸ Ð¾Ð¿Ð¸ÑÑÐ²Ð°ÐµÑÑÑ Ð¾Ð±Ð»Ð°ÑÑÑ Ð½Ð°ÑÐºÐ¸, Ðº ÐºÐ¾ÑÐ¾ÑÐ¾Ð¹ Ð¿ÑÐ¸Ð½Ð°Ð´Ð»ÐµÐ¶Ð¸Ñ Ð´Ð°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ°, ÐºÑÐ°ÑÐºÐ¾ ÑÐ°ÑÑÐºÐ°Ð·ÑÐ²Ð°ÐµÑÑÑ Ð¾Ð± Ð¾Ð±ÑÐµÐºÑÐµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¸ Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½ÑÑ Ð¾Ð±Ð»Ð°ÑÑÑÑ ÐµÐ³Ð¾ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ. Ð Ð¿ÐµÑÐ²Ð¾Ð¹ Ð³Ð»Ð°Ð²Ðµ Ð¿ÑÐ¸Ð²ÐµÐ´ÐµÐ½Ð¾ ÑÐµÐ¾ÑÐµÑÐ¸ÑÐµÑÐºÐ¾Ðµ Ð¾Ð±Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð¸Ðµ, Ð¾Ð¿Ð¸ÑÐ°Ð½Ð¸Ðµ Ð¿Ð¾Ð´Ð¾Ð±Ð½ÑÑ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ð¾Ð², ÑÐ°ÑÐºÑÑÐ²Ð°ÐµÑÑÑ ÑÑÑÐ½Ð¾ÑÑÑ Ð¼ÐµÑÐ¾Ð´Ð° Ð¼ÐµÑÐ°Ð½Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð»ÐµÐ³Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¸ Ð¾Ð¿Ð¸ÑÑÐ²Ð°ÐµÑÑÑ Ð¾Ð±Ð¾ÑÑÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¿ÑÐ¸Ð¼ÐµÐ½ÑÐµÐ¼Ð¾Ðµ Ð´Ð»Ñ ÐµÐ³Ð¾ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¸Ñ. ÐÑÐ¾ÑÐ°Ñ Ð³Ð»Ð°Ð²Ð° ÑÐ¾Ð´ÐµÑÐ¶Ð¸Ñ Ð² ÑÐµÐ±Ðµ Ð¼ÐµÑÐ¾Ð´Ð¸ÐºÐ¸ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¸ Ð°Ð½Ð°Ð»Ð¸Ð· Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐ¾Ð². Ð Ð·Ð°ÐºÐ»ÑÑÐµÐ½Ð¸Ð¸ Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ñ Ð²ÑÐ²Ð¾Ð´Ñ, ÑÐ´ÐµÐ»Ð°Ð½Ð½ÑÐµ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ.
title: ÐÐ¾Ð½ÑÐµÐ¿ÑÐ¸Ñ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ Ð¸Ð½ÑÑÐ°ÑÑÑÑÐºÑÑÑÑ Ð°Ð²ÑÐ¾Ð¼Ð°ÑÐ¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð¹ Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½Ð¾-Ð°Ð½Ð°Ð»Ð¸ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ ÐÑÐºÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð·Ð¾Ð½Ñ Ð Ð¾ÑÑÐ¸Ð¹ÑÐºÐ¾Ð¹ Ð¤ÐµÐ´ÐµÑÐ°ÑÐ¸Ð¸
title: Ð¼Ð°Ð³Ð¸ÑÑÐµÑÑÐºÐ°Ñ Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ñ
titleType: Subtitle
title: The Conception of the development of infrastructure of automative information analytical system of the Arctic zone of Russian Federation
Creators: name: ÐÐ»Ð¸Ð·Ð½ÑÐº, ÐÐ³Ð¾ÑÑ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2016
Subjects: ÐÐ½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½ÑÐµ ÑÐ¸ÑÑÐµÐ¼Ñ
ÐÑÐºÑÐ¸ÐºÐ°
Ð°Ð½Ð°Ð»Ð¸ÑÐ¸ÑÐµÑÐºÐ¸Ðµ ÑÐ¸ÑÑÐµÐ¼Ñ
ÑÐµÐ»ÐµÐºÐ¾Ð¼Ð¼ÑÐ½Ð¸ÐºÐ°ÑÐ¸Ð¸
Arctic
analytical systems
telecommunications

description: Ð¢ÐµÐ¼Ð¾Ð¹ Ð¼Ð°Ð³Ð¸ÑÑÐµÑÑÐºÐ¾Ð¹ Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ð¸ ÑÐ²Ð»ÑÐµÑÑÑ ÐºÐ¾Ð½ÑÐµÐ¿ÑÐ¸Ñ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ Ð¸Ð½ÑÑÐ°ÑÑÑÑÐºÑÑÑÑ Ð°Ð²ÑÐ¾Ð¼Ð°ÑÐ¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð¹ Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½Ð¾-Ð°Ð½Ð°Ð»Ð¸ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ ÐÑÐºÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð·Ð¾Ð½Ñ Ð Ð¾ÑÑÐ¸Ð¹ÑÐºÐ¾Ð¹ Ð¤ÐµÐ´ÐµÑÐ°ÑÐ¸Ð¸. Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð° ÐºÐ¾Ð½ÑÐµÐ¿ÑÐ¸Ñ Ð°Ð²ÑÐ¾Ð¼Ð°ÑÐ¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð¹ Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½Ð¾-Ð°Ð½Ð°Ð»Ð¸ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ, Ð¾Ð±Ð»Ð°Ð´Ð°ÑÑÐµÐ¹ ÑÑÐ½ÐºÑÐ¸ÑÐ¼Ð¸ Ð¿Ð¾Ð´Ð´ÐµÑÐ¶ÐºÐ¸ Ð¿ÑÐ¸Ð½ÑÑÐ¸Ñ ÑÐµÑÐµÐ½Ð¸Ð¹, ÑÑÐ°Ð½ÐµÐ½Ð¸Ñ Ð¸ Ð¿ÐµÑÐµÐ´Ð°ÑÐ¸ Ð´Ð°Ð½Ð½ÑÑ Ñ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸ÐµÐ¼ ÑÑÑÐµÑÑÐ²ÑÑÑÐ¸Ñ ÑÐ¸ÑÑÐµÐ¼ ÑÐµÐ»ÐµÐºÐ¾Ð¼Ð¼ÑÐ½Ð¸ÐºÐ°ÑÐ¸Ð¸ Ð² ÐÑÐºÑÐ¸ÐºÐµ.
description: The theme of the master's thesis is the concept of infrastructure development of the automated information-analytical system of the Russian Arctic zone. The concept of automated information analysis system has a function of decision making support, data storage and transfer with the use of existing telecommunications systems in the Arctic zone.
Cluster radioactivity in very heavy nuclei: a new perspective
Creators: name: Routray, T. R.
name: Nayak, Jagajjaya
name: Basu, D. N.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Exotic cluster decay of very heavy nuclei is studied using the microscopic nuclear potentials obtained by folding density dependent M3Y effective interaction with the densities of the cluster and the daughter nuclei. The microscopic nuclear potential, Coulomb interaction and the centrifugal barrier arising out of spin-parity conservation are used to obtain the potential between the cluster and the daughter nuclei. Half life values are calculated in the WKB framework and the preformation factors are extracted. The latter values are seen to have only a very weak dependence on the mass of the emitted cluster.
description: 4 pages including 2 tables
On O(1) contributions to the free energy in Bethe Ansatz systems: the exact g-function
Creators: name: Pozsgay, B.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We investigate the sub-leading contributions to the free energy of Bethe Ansatz solvable (continuum) models with different boundary conditions. We show that the Thermodynamic Bethe Ansatz approach is capable of providing the O(1) pieces if both the density of states in rapidity space and the quadratic fluctuations around the saddle point solution to the TBA are properly taken into account. In relativistic boundary QFT the O(1) contributions are directly related to the exact g-function. In this paper we provide an all-orders proof of the previous results of P. Dorey et al. on the g-function in both massive and massless models. In addition, we derive a new result for the g-function which applies to massless theories with arbitrary diagonal scattering in the bulk.
description: 28 pages, 2 figures, v2: minor corrections, v3: minor corrections and references added
PACAP and VIP increase the expression of myelin- markers in rat schwannoma cells
Creators: name: Scuderi, Soraya
name: Imbesi, Rossella
name: Castorina, Alessandro
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2014
Subjects: myelin; PACAP; VIP; peripheral nerve sheath tumor; myelin-associated glycoprotein; myelin basic protein; protein zero

description: Defining the mechanisms regulating peripheral myelinogenesis in vitro remains a daunting task. One of the major complications is related to the inability of Schwann cells to produce myelin in vitro. However, a limited number of schwannoma cell lines are now being accepted as adequate model systems to study myelin expression since they present most of the features that characterize normal myelinating Schwann cells. PACAP and VIP peptides have been shown to play part in myelin maturation and synthesis in the central nervous system, but no data regarding their potential actions have been reported in the peripheral nervous system, particularly in vitro. In this study, we investigated the effects of both peptides on the expression of myelin-specific markers using the well-established rat RT4 schwannoma cell line. In addition, we endeavored to partly unravel the underlying molecular mechanisms involved. Expression of myelin-specific markers (MAG, MBP and MPZ, respectively) was assessed in cells grown either in the presence of normal serum (10% FBS) or serum starved and treated with or without 100nM PACAP or VIP. Effects of pharmacological blockade of PACAP and VIP receptors as well as of the main signaling pathways on the expression of myelin-markers were also determined. Our data shows that serum starvation (24h) was sufficient to induce a significant increase in the expression of myelin markers. This result was paralleled by a concurrent increase in the endogenous expression of both peptides, as well as of the non-specific PACAP/VIP receptor 2 (VPAC2), but not of VPAC1 or PAC1. Exogenous PACAP or VIP treatment further exacerbated starvation-driven expression of myelin markers, suggesting an active role of these peptides in myelin generation. Interestingly, stimulation with either peptides increased phosphorylation levels of Akt at Ser473 residue whereas they did not affect Erk1/2 activation. Treatment with the PAC1 receptor antagonist (PACAP6-38) had no effects on myelin markers expression while a non-specific VPAC receptor antagonist completely abrogated both starvation and/or starvation + peptide-induced expression of myelin markers. Similar effects were obtained in cell pretreated with the PKA inhibitor (H-89, 10μM), suggesting that peptide-driven induction of myelin markers occurs preferentially via the canonical PKA/Akt signaling pathway. In conclusion, the results here presented provide the basis for future studies on the role of these peptides in physiological myelination and in demyelinating pathologies such as Charcot-Mary-Tooth disease.
description: Italian Journal of Anatomy and Embryology, Vol 118, No 2 (Supplement) 2013
title: Effects of Non‐Surface‐Disturbing Treatments for Native Grass Revegetation on Cheatgrass (Bromus tectorum L.) Metrics and Soil Ion Availabilities
Creators: name: Summerhays, Jan C.R.
Publisher: name: Utah State University
Year: 2011

description: Several restoration methods intended to increase the success of aerially‐seeded perennial grasses were assessed to determine their effects on cheatgrass metrics and soil nutrient bioavailabilities. These methods were: 1) imazapic herbicide application (140 g ai ∙ ha‐1, 210 g ai ∙ ha‐1, and no application [control]), 2) vegetation manipulation treatments (50% sagebrush overstory thinning, 100% sagebrush overstory thinning, sagebrush overstory and/or vegetative thatch burning, and no manipulation [control]), and 3) alternative seeding treatments (aerial seeding with raking, aerial seeding with activated carbon [AC] addition, aerial seeding with sucrose addition, and regular aerial seeding [control]). Treatments were arranged in 3‐way factorial designs, which allowed main effects and interactions between treatments to be assessed. Responses were followed for two growing seasons following treatment.
Main effects of treatments and their interactions on cheatgrass metrics are described in Chapter 2. Herbicide reduced cheatgrass weights and tiller and spikelet numbers in 2009, but these variables were greater than in no‐herbicide plots in 2010. Burning decreased cheatgrass densities but increased weights and tiller and spikelet numbers in both years. One hundred percent sagebrush thinning resulted in greater cheatgrass weights and tiller and spikelet numbers in both years and greater densities in 2010. Sucrose addition decreased cheatgrass weights and tiller and spikelet numbers in 2009, but increased these variables in 2010. An interaction between AC and herbicide treatment was observed, with AC potentially sequestering and lessening the negative effect of herbicide on cheatgrass. Aerial seeding with raking and 50% sagebrush thinning treatments were not found to significantly affect cheatgrass either year.
The effects of treatments (herbicide, 50% sagebrush thinning, aerial seeding on snow, and aerial seeding with raking treatments omitted) on soil nutrient availabilities are described in Chapter 3. We used ion exchange resin (IER) membrane probes to measure extractable quantities of 15 ions over three time periods following treatment applications. Burning resulted in short‐term increases in many soil nutrient availabilities, including nitrate (NO3 ‐), phosphate (H2PO4 ‐), and sulfate (SO4 2‐). Sucrose addition reduced availabilities of NO3 ‐ and H2PO4 ‐ during the first winter and growing season. No changes were detected with AC addition or 100% sagebrush thinning during any sampling time.
Positive effect of Mesenchymal Stem Cells therapeutic administration on chronic Experimental Autoimmune Encephalomyelitis
Creators: name: Scuteri, Arianna
name: Donzelli, Elisabetta
name: Rigolio, Roberta
name: Ballarini, Elisa
name: Monfrini, Marianna
name: Ravasi, Maddalena
name: Chiorazzi, Alessia
name: Sala, Barbara
name: Meregalli, Cristina
name: Tredici, Giovanni
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2014
Subjects: mesenchymal stem cells; chronic EAE; demyelination

description: Multiple Sclerosis (MS) is a crippling chronic disease of the Central Nervous System caused by the presence of self-antibodies which progressively damage axonal myelin sheath, leading to axonal transmission impairment and to the development of neurological symptoms. MS is characterized by a Relapsing-Remitting course, and current therapies rely only on the use of immunosuppressive drugs, which are however unable to reverse disease progression. Encouraging results have been obtained in preclinical studies with the administration of Mesenchymal Stem Cells (MSCs) before disease onset (Zappia et al., 2005). Here, we investigate the therapeutic potential of MSC administration after disease onset into an animal model of MS, represented by Dark Agouti rats affected by chronic Relapsing-Remitting Experimental Autoimmune Encephalomyelitis (EAE) (Cavaletti et al., 2004). 106 MSC were intravenously injected in EAE rats after disease onset. Clinical score was assessed daily, and after 45 days rats were sacrificed and histological analysis of spinal cords performed to evaluate the demyelinating lesions. After the first peak of disease, no further relapses were observed in EAE rats treated with MSCs, differently from what observed in EAE group. Histological analysis demonstrated the presence of demyelinated plaques in spinal cords of EAE rats, (Luxol fast Blue staining and anti-MBP immunohystochemistry). On the contrary the therapeutic schedule with MSCs significantly reduces the number and the extension of demyelinated areas in the spinal cords, confirming clinical score evaluations. These results demonstrated that MSCs ameliorate the clinical course of EAE and hamper the disease relapsing by reducing the areas of demyelinated lesions. Granted by MIUR – FIRB Futuro in Ricerca 2008 Prot. N° RBFR08VSVI_001.
description: Italian Journal of Anatomy and Embryology, Vol 118, No 2 (Supplement) 2013
Colloquium: Trapped ions as quantum bits -- essential numerical tools
Creators: name: Singer, Kilian
name: Poschinger, Ulrich
name: Murphy, Michael
name: Ivanov, Peter
name: Ziesel, Frank
name: Calarco, Tommaso
name: Schmidt-Kaler, Ferdinand
Publisher: name: arXiv
Year: 2009
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Trapped, laser-cooled atoms and ions are quantum systems which can be experimentally controlled with an as yet unmatched degree of precision. Due to the control of the motion and the internal degrees of freedom, these quantum systems can be adequately described by a well known Hamiltonian. In this colloquium, we present powerful numerical tools for the optimization of the external control of the motional and internal states of trapped neutral atoms, explicitly applied to the case of trapped laser-cooled ions in a segmented ion-trap. We then delve into solving inverse problems, when optimizing trapping potentials for ions. Our presentation is complemented by a quantum mechanical treatment of the wavepacket dynamics of a trapped ion. Efficient numerical solvers for both time-independent and time-dependent problems are provided. Shaping the motional wavefunctions and optimizing a quantum gate is realized by the application of quantum optimal control techniques. The numerical methods presented can also be used to gain an intuitive understanding of quantum experiments with trapped ions by performing virtual simulated experiments on a personal computer. Code and executables are supplied as supplementary online material (http://kilian-singer.de/ent).
description: accepted for publication in Review of Modern Physics 2010
title: Ð£Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ðµ ÑÐ½ÐµÑÐ³ÐµÑÐ¸ÑÐµÑÐºÐ¸Ð¼Ð¸ ÑÐ¸ÑÑÐµÐ¼Ð°Ð¼Ð¸. Ð§. 2, Ð­Ð»ÐµÐºÑÑÐ¾Ð¼ÐµÑ Ð°Ð½Ð¸ÑÐµÑÐºÐ¸Ðµ Ð¿ÑÐ¾ÑÐµÑÑÑ
Creators: name: ÐÐ¾Ð·Ð»Ð¾Ð², ÐÐ»Ð°Ð´Ð¸Ð¼Ð¸Ñ
Publisher: name: ÐÐ·Ð´-Ð²Ð¾ ÐÐ¾Ð»Ð¸ÑÐµÑÐ½. ÑÐ½-ÑÐ°
Year: 2006
Subjects: Ð­Ð½ÐµÑÐ³ÐµÑÐ¸ÑÐµÑÐºÐ¸Ðµ ÑÐ¸ÑÑÐµÐ¼Ñ

description: ÐÐ¾Ð½Ð¾Ð³ÑÐ°ÑÐ¸Ñ ÑÐ²Ð»ÑÐµÑÑÑ Ð²ÑÐ¾ÑÐ¾Ð¹ ÑÐ°ÑÑÑÑ ÑÐµÑÐ¸Ð¸ Â«Ð£Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ðµ ÑÐ½ÐµÑÐ³ÐµÑÐ¸ÑÐµÑÐºÐ¸Ð¼Ð¸ ÑÐ¸ÑÑÐµÐ¼Ð°Ð¼Ð¸Â» Ð¸ Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¿ÑÐ¾Ð±Ð»ÐµÐ¼Ðµ Ð¾Ð¿ÑÐ¸Ð¼Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ ÑÐ°ÑÑÐ¾ÑÐ¾Ð¹ Ð¸ Ð°ÐºÑÐ¸Ð²Ð½Ð¾Ð¹ Ð¼Ð¾ÑÐ½Ð¾ÑÑÑÑ ÑÐ»ÐµÐºÑÑÐ¾ÑÐ½ÐµÑÐ³ÐµÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¾Ð±ÑÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ð¹, Ð²ÐºÐ»ÑÑÐ°ÐµÑ Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ ÑÐ»ÐµÐºÑÑÐ¾Ð¼ÐµÑÐ°Ð½Ð¸ÑÐµÑÐºÐ¸Ñ Ð¿ÑÐ¾ÑÐµÑÑÐ¾Ð², Ð°Ð½Ð°Ð»Ð¸Ð· Ð¸ ÑÐ¸Ð½ÑÐµÐ· Ð½ÐµÐ»Ð¸Ð½ÐµÐ¹Ð½ÑÑ ÑÐ¸ÑÑÐµÐ¼ Ð¾Ð³ÑÐ°Ð½Ð¸ÑÐµÐ½Ð¸Ñ Ð¿ÐµÑÐµÑÐ¾ÐºÐ¾Ð² Ð°ÐºÑÐ¸Ð²Ð½Ð¾Ð¹ Ð¼Ð¾ÑÐ½Ð¾ÑÑÐ¸ Ð¸ ÑÐµÐ³ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ ÑÐ°ÑÑÐ¾ÑÑ Ð¸ Ð¾Ð±Ð¼ÐµÐ½Ð½Ð¾Ð¹ Ð¼Ð¾ÑÐ½Ð¾ÑÑÐ¸ ÑÐ½ÐµÑÐ³ÐµÑÐ¸ÑÐµÑÐºÐ¸Ñ ÑÐ¸ÑÑÐµÐ¼. Ð Ð°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ñ Ð²Ð¾Ð¿ÑÐ¾ÑÑ ÑÐ¸Ð½ÑÐµÐ·Ð° ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ð¹ Ð¿Ð¾ ÐºÑÐ¸ÑÐµÑÐ¸Ñ ÑÐ½ÐµÑÐ³ÐµÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð±ÐµÐ·Ð¾Ð¿Ð°ÑÐ½Ð¾ÑÑÐ¸. ÐÐ¾Ð½Ð¾Ð³ÑÐ°ÑÐ¸Ñ Ð¿ÑÐµÐ´Ð½Ð°Ð·Ð½Ð°ÑÐµÐ½Ð° Ð´Ð»Ñ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°ÑÐµÐ»ÐµÐ¹ Ð¿ÑÐ¾Ð±Ð»ÐµÐ¼ Ð°Ð²ÑÐ¾Ð¼Ð°ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ ÑÐ½ÐµÑÐ³ÐµÑÐ¸ÑÐµÑÐºÐ¸Ð¼Ð¸ ÑÐ¸ÑÑÐµÐ¼Ð°Ð¼Ð¸, Ð° ÑÐ°ÐºÐ¶Ðµ Ð¼Ð°Ð³Ð¸ÑÑÑÐ¾Ð², Ð¾Ð±ÑÑÐ°ÑÑÐ¸ÑÑÑ Ð¿Ð¾ Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸ÑÐ¼ Â«Ð¡Ð¸ÑÑÐµÐ¼Ð½ÑÐ¹ Ð°Ð½Ð°Ð»Ð¸Ð· Ð¸ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸ÐµÂ», Â«ÐÐ²ÑÐ¾Ð¼Ð°ÑÐ¸Ð·Ð°ÑÐ¸Ñ Ð¸ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸ÐµÂ» Ð¸ Ð´Ñ.
description: ÐÐµÑÐ°ÑÐ°ÐµÑÑÑ Ð¿Ð¾ ÑÐµÑÐµÐ½Ð¸Ñ ÑÐµÐ´Ð°ÐºÑÐ¸Ð¾Ð½Ð½Ð¾-Ð¸Ð·Ð´Ð°ÑÐµÐ»ÑÑÐºÐ¾Ð³Ð¾ ÑÐ¾Ð²ÐµÑÐ° Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¾Ð³Ð¾ Ð³Ð¾ÑÑÐ´Ð°ÑÑÑÐ²ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑÐ°.
Promotional events as an effective strategy to elicit blood donations: an evaluation of cost and benefit
Creators: name: Chandler, Torsten
name: Hiller, Jens
name: Peine, Sven
name: Stargardt, Tom
Publisher: name: Zenodo
Year: 2020

description: Abstract submitted and accepted for a presentation at the German Health Economic Association (DGGÖ) Conference 2020 (The conference was cancelled due to Covid-19)
title: Ð¡ÑÑÐ°ÑÐµÐ³Ð¸Ñ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³Ð° Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° ÐµÐ³Ð¾ Ð¸Ð½Ð½Ð¾Ð²Ð°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð³Ð¾ Ð¿Ð¾ÑÐµÐ½ÑÐ¸Ð°Ð»Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
Creators: name: ÐÑÑÐ¸Ð¿Ð¾Ð²Ð°, ÐÐ½Ð°ÑÑÐ°ÑÐ¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2018
Subjects: Ð¸Ð½Ð½Ð¾Ð²Ð°ÑÐ¸Ð¾Ð½Ð½ÑÐ¹ Ð¿Ð¾ÑÐµÐ½ÑÐ¸Ð°Ð»
adl Ð¼Ð¾Ð´ÐµÐ»Ñ
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description: ÐÐ±ÑÐµÐºÑÐ¾Ð¼ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐ²Ð»ÑÐµÑÑÑ Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³, Ð° Ð¿ÑÐµÐ´Ð¼Ðµ-ÑÐ¾Ð¼ - Ð¸Ð½Ð½Ð¾Ð²Ð°ÑÐ¸Ð¾Ð½Ð½ÑÐ¹ Ð¿Ð¾ÑÐµÐ½ÑÐ¸Ð°Ð» ÑÐµÐ³Ð¸Ð¾Ð½Ð°.
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ÐÑÐ¾Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ñ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÐµ Ð´Ð°Ð½Ð½ÑÐµ, Ð²ÑÐ±ÑÐ°Ð½ Ð½Ð°Ð¸Ð±Ð¾Ð»ÐµÐµ Ð¿Ð¾Ð´ÑÐ¾Ð´ÑÑÐ¸Ð¹ Ð²Ð¸Ð´ ÑÑÑÐ°ÑÐµÐ³Ð¸Ð¸, ÑÑÐ¾ÑÐ¼ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½ Ð¿Ð¾ÑÐ°Ð³Ð¾Ð²ÑÐ¹ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑ Ð¼Ðµ-ÑÐ¾Ð¿ÑÐ¸ÑÑÐ¸Ð¹, Ð¿Ð¾Ð·Ð²Ð¾Ð»ÑÑÑÐ¸Ð¹ ÑÐ»ÑÑÑÐ¸ÑÑ ÑÐ»Ð¾Ð¶Ð¸Ð²ÑÑÑÑÑ ÑÐ¸ÑÑÐ°ÑÐ¸Ñ.
Morpho-functional alterations of colonic neuromuscular compartment in experimental Parkinson’s disease
Creators: name: Segnani, C.
name: Ippolito, C.
name: Stocchi, S.
name: Fornai, M.
name: Pellegrini, C.
name: Blandizzi, C.
name: Dini, S.
name: Dolfi, A.
name: Bernardini, N.
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2014
Subjects: Parkinson’s disease; experimental model; colon motility dysfunction; enteric nervous system; neurochemical coding

description: Parkinson’s disease (PD) is a degenerative neurological disorder, which is often associated with gastrointestinal symptoms. Among these disturbances, constipation has received considerable attention owing to its potential value as early marker of disease onset [1, 2]. Our study aims at evaluating motor dysfunctions and neurochemical coding of colonic neuromuscular compartment in a rat model of PD. Experimental PD was induced in rats by unilateral injection of 6-idroxydopamine (6-OHDA) into two sites of the right medial forebrain bundle. Functional and morphological studies were carried out 28 and 56 days after treatment. Colonic circular muscle contractions were revorded in organ baths after electrical stimulation or in the presence of exogenous substance P (SP). Colonic samples were examined by immunohistochemistry for the following parameters: density of myenteric HuC/D+ neurons and GFAP+ glial cells; distribution pattern and quantitative expression of SP, tyrosine hidroxylase (TH) and choline acethyltransferase (ChAT). Contractions elicited by electrically evoked tachykinin release as well as by exogenous SP were enhanced at both day 28 and 56, as compared to controls. Myenteric ganglia of PD animals displayed a significant increase in HuC/D+ neuron density, but no alteration in GFAP+ expression. SP+ myenteric neurons progressively increased over time, while the expression of TH and ChAT were significantly reduced at both time points. Experimental PD, elicited by nigrostriatal dopaminergic degeneration, is associated with functional and histopathological/neurochemical changes of the colonic neuromuscular compartment. The enhanced tachykinenergic motor control, associated with an upregulation of neuronal SP expression, together with reduced expression of TH and ChAT, may account for the colonic motor dysfunctions often associated to PD.
description: Italian Journal of Anatomy and Embryology, Vol 118, No 2 (Supplement) 2013
Black holes in asymptotically Lifshitz spacetime
Creators: name: Danielsson, Ulf H.
name: Thorlacius, Larus
Publisher: name: arXiv
Year: 2008
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: A model of 3+1 dimensional gravity with negative cosmological constant coupled to abelian gauge fields has been proposed as a gravity dual for Lifshitz like critical phenomena in 2+1 dimensions. The finite temperature behavior is described by black holes that are asymptotic to the Lifshitz fixed point geometry. There is a one-parameter family of charged black holes, where the magnitude of the charge is uniquely determined by the black hole area. These black holes are thermodynamically stable and become extremal in the limit of vanishing size. The theory also has a discrete spectrum of localized objects described by non-singular spacetime geometries. The finite temperature behavior of Wilson loops is reminiscent of strongly coupled gauge theories in 3+1 dimensions, including screening at large distances.
description: 19 pages, 15 figures in jpeg format, v2: added reference
title: Ð¡Ð¾Ð²ÐµÑÑÐµÐ½ÑÑÐ²Ð¾Ð²Ð°Ð½Ð¸Ðµ ÐºÐ°ÑÑÐ¾Ð²Ð¾Ð³Ð¾ Ð¾Ð±ÑÐ»ÑÐ¶Ð¸Ð²Ð°Ð½Ð¸Ñ ÑÐµÐ³Ð¸Ð¾Ð½Ð°Ð»ÑÐ½ÑÑ Ð¸ Ð¼ÐµÑÑÐ½ÑÑ Ð±ÑÐ´Ð¶ÐµÑÐ¾Ð² ÑÐµÐ´ÐµÑÐ°Ð»ÑÐ½ÑÐ¼ ÐÐ°Ð·Ð½Ð°ÑÐµÐ¹ÑÑÐ²Ð¾Ð¼
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: Ð§ÑÐºÐ¸ÑÐµÐ²Ð°, Ð£Ð»ÑÑÐ½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: ÑÐµÐ´ÐµÑÐ°Ð»ÑÐ½Ð¾Ðµ ÐºÐ°Ð·Ð½Ð°ÑÐµÐ¹ÑÑÐ²Ð¾
ÐºÐ°ÑÑÐ¾Ð²Ð¾Ðµ Ð¾Ð±ÑÐ»ÑÐ¶Ð¸Ð²Ð°Ð½Ð¸Ðµ
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Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÑÑÑÐºÑÑÑÐ°

description: Ð ÑÐ°Ð±Ð¾ÑÐµ Ð¿ÑÐ¸Ð²ÐµÐ´ÐµÐ½Ð° Ð¾Ð±ÑÐ°Ñ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸ÐºÐ° Ð¤ÐµÐ´ÐµÑÐ°Ð»ÑÐ½Ð¾Ð³Ð¾ ÐÐ°Ð·Ð½Ð°ÑÐµÐ¹ÑÑÐ²Ð° ÐµÐ³Ð¾ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÑÑÑÐºÑÑÑÐ°, Ð¿ÑÐ¾Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½ Ð´Ð¾ÐºÑÐ¼ÐµÐ½ÑÐ¾Ð¾Ð±Ð¾ÑÐ¾Ñ Ð¿ÑÐ¸ ÐºÐ°ÑÑÐ¾Ð²Ð¾Ð¼ Ð¾Ð±ÑÐ»ÑÐ¶Ð¸Ð²Ð°Ð½Ð¸Ð¸ Ð¸ÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð¸Ñ Ð±ÑÐ´Ð¶ÐµÑÐ° ÑÑÐ±ÑÐµÐºÑÐ° Ð Ð¤ Ð¸ Ð¾ÑÐ½Ð¾Ð²Ð½ÑÐµ Ð¼ÐµÑÐ¾Ð¿ÑÐ¸ÑÑÐ¸Ñ Ð¿Ð¾ ÑÐµÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¡ÑÑÐ°ÑÐµÐ³Ð¸ÑÐµÑÐºÐ°Ñ ÐºÐ°ÑÑÐ° ÐÐ°Ð·Ð½Ð°ÑÐµÐ¹ÑÑÐ²Ð° Ð Ð¾ÑÑÐ¸Ð¸ Ð½Ð° 2016-2020 Ð³Ð¾Ð´Ñ Ð² ÑÐ°ÑÑÐ¸ ÐºÐ°ÑÑÐ¾Ð²Ð¾Ð³Ð¾ Ð¾Ð±ÑÐ»ÑÐ¶Ð¸Ð²Ð°Ð½Ð¸Ñ Ð¸ÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð¸Ñ Ð±ÑÐ´Ð¶ÐµÑÐ°. Ð Ð°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ñ Ð½Ð¾ÑÐ¼Ð°ÑÐ¸Ð²Ð½Ð¾-Ð¿ÑÐ°Ð²Ð¾Ð²ÑÐµ Ð°ÐºÑÑ Ð² ÑÐ°ÑÑÐ¸ ÐºÐ°ÑÑÐ¾Ð²Ð¾Ð³Ð¾ Ð¾Ð±ÑÐ»ÑÐ¶Ð¸Ð²Ð°Ð½Ð¸Ñ Ð¸ Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ÑÑÐ¸ Ð¾Ð±ÑÐ»ÑÐ¶Ð¸Ð²Ð°Ð½Ð¸Ñ ÑÐµÐ³Ð¸Ð¾Ð½Ð°Ð»ÑÐ½ÑÑ Ð±ÑÐ´Ð¶ÐµÑÐ¾Ð². ÐÑÐ¿Ð¾Ð»Ð½ÐµÐ½ Ð°Ð½Ð°Ð»Ð¸Ð· Ð¼ÐµÑÐ¾Ð´Ð¾Ð² ÑÐ¾Ð²ÐµÑÑÐµÐ½ÑÑÐ²Ð¾Ð²Ð°Ð½Ð¸Ðµ ÐºÐ°ÑÑÐ¾Ð²Ð¾Ð³Ð¾ Ð¾Ð±ÑÐ»ÑÐ¶Ð¸Ð²Ð°Ð½Ð¸Ñ ÑÐµÐ´ÐµÑÐ°Ð»ÑÐ½ÑÐ¼ ÐÐ°Ð·Ð½Ð°ÑÐµÐ¹ÑÑÐ²Ð¾Ð¼. Ð Ð·Ð°Ð²ÐµÑÑÐµÐ½Ð¸Ð¸ Ð±ÑÐ»Ð¸ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ñ ÑÐµÐºÐ¾Ð¼ÐµÐ½Ð´Ð°ÑÐ¸Ð¸ Ð¿Ð¾ Ð¿Ð¾Ð²ÑÑÐµÐ½Ð¸Ñ ÐºÐ°ÑÐµÑÑÐ²Ð° ÐºÐ°ÑÑÐ¾Ð²Ð¾Ð³Ð¾ Ð¾Ð±ÑÐ»ÑÐ¶Ð¸Ð²Ð°Ð½Ð¸Ñ Ð¸ÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð¸Ñ Ð±ÑÐ´Ð¶ÐµÑÐ¾Ð² ÑÑÐ±ÑÐµÐºÑÐ¾Ð² Ð Ð¤ Ð¸ Ð¼ÑÐ½Ð¸ÑÐ¸Ð¿Ð°Ð»ÑÐ½ÑÑ Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ð¹.
The thermal conductivities of some hydrocarbons
Creators: name: Levelton, Bruce H.
Publisher: name: University of British Columbia
Year: 2012

description: The Bates Calorimeter for measuring the heat conductivities of hydrocarbons was partially reconstructed so as to diminish the heat loss through the walls of the iron container. This was done by imbedding some nichrome wire heating elements in the insulating materials just outside iron wall. The current sent through this coil was so controlled as to reduce the heat loss from the liquid at this point. A series of measurements on several hydrocarbons gave the results below. Trans decahydronaphthalene k₃₅ = 0.001155 Cis k₃₅ = 0.001178 N decane k₃₅ = 0.000652 N dodecane k₃₅ = 0.000654 N tetradecane k₃₅ = 0.000650 N hexadecane k₃₅ = 0.000650
title: Ð¡ÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð¸Ðµ ÐÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¸ ÐÐ±ÑÐµÐ´Ð¸Ð½ÐµÐ½Ð½ÑÑ ÐÐ°ÑÐ¸Ð¹ (1945â1961)
title: Ð¼Ð¾Ð½Ð¾Ð³ÑÐ°ÑÐ¸Ñ
titleType: Subtitle
Creators: name: ÐÐ¾Ð²Ð¸Ðº, ÐÐ¼Ð¸ÑÑÐ¸Ð¹
name: ÐÐ¾Ð²ÐµÐ½Ð´Ð°, ÐÐ»ÐµÐºÑÐµÐ¹
Publisher: name: ÐÐÐÐÐ¢ÐÐ¥-ÐÐ ÐÐ¡Ð¡
Year: 2023
Subjects: ÐÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ñ ÐÐ±ÑÐµÐ´Ð¸Ð½ÐµÐ½Ð½ÑÑ ÐÐ°ÑÐ¸Ð¹
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description: Ð Ð¼Ð¾Ð½Ð¾Ð³ÑÐ°ÑÐ¸Ð¸ Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ñ Ð¾ÑÐ½Ð¾Ð²Ð½ÑÐµ Ð°ÑÐ¿ÐµÐºÑÑ ÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð¸Ñ Ð¸ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ñ ÐÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¸ ÐÐ±ÑÐµÐ´Ð¸Ð½ÐµÐ½Ð½ÑÑ ÐÐ°ÑÐ¸Ð¹ Ð² Ð¿ÐµÑÐ¸Ð¾Ð´ 1945â1961 Ð³Ð³., ÑÑÐ°Ð²ÑÐµÐ¹ ÑÑÐµÑÐ¶Ð½ÐµÐ²Ð¾Ð¹ ÑÑÑÑÐºÑÑÑÐ¾Ð¹ Ð²ÑÐµÐ¹ Ð¼ÐµÐ¶Ð´ÑÐ½Ð°ÑÐ¾Ð´Ð½Ð¾Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ Ð¿Ð¾ÑÐ»ÐµÐ²Ð¾ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð¼Ð¸ÑÐ°. Ð Ð³Ð»Ð°Ð²Ð°Ñ Ð¼Ð¾Ð½Ð¾Ð³ÑÐ°ÑÐ¸Ð¸ ÑÐ°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ñ Ð¿Ð¾Ð·Ð¸ÑÐ¸Ð¸ Ð´ÐµÑÐ¶Ð°Ð²-Ð¿Ð¾Ð±ÐµÐ´Ð¸ÑÐµÐ»ÑÐ½Ð¸Ñ Ð½Ð° Ð¿Ð¾Ð´Ð³Ð¾ÑÐ¾Ð²Ð¸ÑÐµÐ»ÑÐ½Ð¾Ð¼ ÑÑÐ°Ð¿Ðµ ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ñ ÐÐÐ; Ð¸ÑÐ¾Ð³Ð¸ ÐºÐ¾Ð½ÑÐµÑÐµÐ½ÑÐ¸Ð¹ Ð² ÐÑÐ¼Ð±Ð°ÑÑÐ¾Ð½-ÐÐºÑÐµ Ð¸ Ð¡Ð°Ð½-Ð¤ÑÐ°Ð½ÑÐ¸ÑÐºÐ¾; ÑÐµÐ»Ð¸, Ð¿ÑÐ¸Ð½ÑÐ¸Ð¿Ñ, ÑÑÑÑÐºÑÑÑÐ° Ð¸ Ð¿Ð¾Ð»Ð½Ð¾Ð¼Ð¾ÑÐ½ÑÐµ Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð¸ÑÐµÐ»ÑÑÑÐ²Ð° ÐÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¸ ÐÐ±ÑÐµÐ´Ð¸Ð½ÐµÐ½Ð½ÑÑ ÐÐ°ÑÐ¸Ð¹; Ð£ÑÑÐ°Ð² ÐÐÐ Ð¸ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÑ Ð¿ÐµÑÐ²ÑÑ Ð³ÐµÐ½ÐµÑÐ°Ð»ÑÐ½ÑÑ ÑÐµÐºÑÐµÑÐ°ÑÐµÐ¹ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¸; ÑÐ¾Ð»Ñ ÐÐÐ Ð² ÑÐ°Ð·ÑÐµÑÐµÐ½Ð¸Ð¸ Ð¼ÐµÐ¶Ð´ÑÐ½Ð°ÑÐ¾Ð´Ð½ÑÑ ÐºÑÐ¸Ð·Ð¸ÑÐ¾Ð² Ð² ÑÐ°ÑÑÐ¼Ð°ÑÑÐ¸Ð²Ð°ÐµÐ¼ÑÐ¹ Ð¿ÐµÑÐ¸Ð¾Ð´. ÐÐ¾Ð½Ð¾Ð³ÑÐ°ÑÐ¸Ñ Ð¿ÑÐµÐ´Ð½Ð°Ð·Ð½Ð°ÑÐµÐ½Ð° Ð´Ð»Ñ ÑÐ¿ÐµÑÐ¸Ð°Ð»Ð¸ÑÑÐ¾Ð²-Ð¼ÐµÐ¶Ð´ÑÐ½Ð°ÑÐ¾Ð´Ð½Ð¸ÐºÐ¾Ð², Ð¸Ð½ÑÐµÑÐµÑÑÑÑÐ¸ÑÑÑ Ð¸ÑÑÐ¾ÑÐ¸ÐµÐ¹ Ð¸ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÑÑ ÐÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¸ ÐÐ±ÑÐµÐ´Ð¸Ð½ÐµÐ½Ð½ÑÑ ÐÐ°ÑÐ¸Ð¹, Ð° ÑÐ°ÐºÐ¶Ðµ Ð´Ð»Ñ ÑÑÑÐ´ÐµÐ½ÑÐ¾Ð², Ð°ÑÐ¿Ð¸ÑÐ°Ð½ÑÐ¾Ð² Ð¸ Ð¿ÑÐµÐ¿Ð¾Ð´Ð°Ð²Ð°ÑÐµÐ»ÐµÐ¹ Ð²ÑÐ·Ð¾Ð².
Chondrocyte expression of apoptotic and pro- inflammatory factors in the development of post- traumatic arthritis in humans
Creators: name: Sena, Paola
name: Benincasa, Marta
name: Cavani, Francesco
name: Ferretti, Marzia
name: Smargiassi, Alberto
name: Manfredini, Giuseppe
name: Palumbo, Carla
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2014
Subjects: articular fracture; post-traumatic arthritis; chondrocyte culture; apoptosis; inflammation

description: The development of post-traumatic arthritis following intra-articular fracture remains an important unsolved clinical problem. The possibility that extensive chondrocyte apoptosis occurs following intra-articular fracture, thus contributing to the development of post-traumatic arthritis, has received increasing attention [1]. It has been demonstrated the existence of a direct correlation between the rate of apoptosis and the severity of osteoarthritis [2]. Pharmacologic inhibitors of enzymes involved in apoptosis have been explored as potential therapeutic agents [3]. In the present study we aimed to deepen the characterization of apoptotic mediators, expressed by chondrocytes, involved in human post-traumatic arthritis following intra-articular fracture and the possible implication of pro-inflammatory receptors in arthritis. The expression of a panel of pro/anti apoptotic factors (Caspase-3, PARP-1, BCL2) and inflammation-related receptors (ChemR23) were analysed in chondrocytes from patients undergoing surgery for intra-articular calcaneal fractures. The factors were investigated by immunofluorescence coupled with confocal analysis and western blotting, followed by densitometric evaluation of chondrocyte cultures harvested from patients with intra-articular fractures compared with control ones. The results clearly demonstrated that a statistically significant difference exists in the expression of pro/anti apoptotic factors and ChemR23 between fractured and control patients. In conclusion our data suggest that increased chondrocyte death, occurring after cartilage injury together with inflammatory process, could play a pivotal role in the onset of arthritic disease.
description: Italian Journal of Anatomy and Embryology, Vol 118, No 2 (Supplement) 2013
The temporomandibular joint: from classical anatomy to modern functional assessments
Creators: name: Sforza, Chiarella
name: Mapelli, Andrea
name: Serralunga, Sergio
name: Tartaglia, Gianluca M.
name: Lodetti, Gianluigi
name: De Felicio, Claudia M.
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2014
Subjects: temporomandibular joint; phylogenesis; motion analysis

description: The temporomandibular joint (TMJ) is a complex synovial articulation, made by the mandibular condyles and the squamous surface of temporal bones. The skeletal surfaces are highly incongruent and are separated by a fibrous disc, that reduces joint incongruence, increases joint stability, and allows mandibular movements with six degrees-of-freedom. In mammals, TMJ characteristics are so unique that are used to define the class Mammalia. TMJ development is strictly related to that of the middle ear, and it represents a complex modification of a phylogenetically older articulation found in non-mammalian vertebrates [1]. In particular, human TMJ possesses several differences from that of the other mammals, and animal models cannot be easily used to investigate its dynamic and kinematic characteristics. Several hypotheses have been proposed to describe TMJ movements and intra-articular force, but a major limitation lies in the difficulty in the actual assessment of condylar movements. Indeed, no current imaging system can provide a complete three-dimensional evaluation of TMJ motion: conventional radiographic images lack the third dimension and cannot inform about the behaviour of soft tissues; CT provides all three spatial planes but still cannot image the disc and related structures; magnetic resonance (MR), while providing adequate details of soft tissue structures, lacks the necessary dynamic information. Therefore, most of these studies are based on biomechanical models, where TMJ motion is recorded with three-dimensional motion analyzers, and mathematical and geometrical calculations provide the necessary background for the hypotheses about joint mechanical behaviour [2].
description: Italian Journal of Anatomy and Embryology, Vol 118, No 2 (Supplement) 2013
High magnetic field theory for the local density of states in graphene with smooth arbitrary potential landscapes
Creators: name: Champel, Thierry
name: Florens, Serge
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study theoretically the energy and spatially resolved local density of states (LDoS) in graphene at high perpendicular magnetic field. For this purpose, we extend from the Schrödinger to the Dirac case a semicoherent-state Green's-function formalism, devised to obtain in a quantitative way the lifting of the Landau-level degeneracy in the presence of smooth confinement and smooth disordered potentials. Our general technique, which rigorously describes quantum-mechanical motion in a magnetic field beyond the semi-classical guiding center picture of vanishing magnetic length (both for the ordinary two-dimensional electron gas and graphene), is connected to the deformation (Weyl) quantization theory in phase space developed in mathematical physics. For generic quadratic potentials of either scalar (i.e., electrostatic) or mass (i.e., associated with coupling to the substrate) types, we exactly solve the regime of large magnetic field (yet at finite magnetic length - formally, this amounts to considering an infinite Fermi velocity) where Landau-level mixing becomes negligible. Hence, we obtain a closed-form expression for the graphene Green's function in this regime, providing analytically the discrete energy spectra for both cases of scalar and mass parabolic confinement. Furthermore, the coherent-state representation is shown to display a hierarchy of local energy scales ordered by powers of the magnetic length and successive spatial derivatives of the local potential, which allows one to devise controlled approximation schemes at finite temperature for arbitrary and possibly disordered potential landscapes. As an application, we derive general analytical non-perturbative expressions for the LDoS, which may serve as a good starting point for interpreting experimental studies.
description: 27 pages, 2 figures ; v2: typos corrected, corresponds to published version
Animal models are reliably mimicking human diseases? A morphological study that compares animal and human NAFLD
Creators: name: Solinas, Paola
name: Lilliu, Alberta
name: Cossu, Margherita
name: Civolani, Alberto
name: Demelia, Luigi
name: Isola, Raffaella
Publisher: name: Italian Journal of Anatomy and Embryology
Year: 2014
Subjects: animal model; NAFLD; electron microscopy

description: Nonalcoholic fatty liver disease (NAFLD) affects up to 20% of western population and, when untreated, it can progress from simple fatty liver or steatosis to a more severe condition, such as NASH (non alcoholic steatohepatitis) and cirrhosis (1). NAFLD is a clinical-pathological syndrome that include a wide spectrum of morphological alteration but such studies on humans are not copious, as human samples are difficult to obtain because of ethical limitations. Experimental models are crucial to study steatosis’ progression, not only for elucidating the pathogenesis of NAFLD but also in examining therapeutic effects of various agents. Animal models may be developed on genetic or nutritional basis, or a combination of both. It is important to select the best model fitted to the aim of the study. But the question that arises is: can the animal model reflect hepatic histopathology and pathophysiology of human NAFLD? This question is always neglected as well as the evaluation of ultrastructural features of NAFLD. In order to overcome this lack of investigations we compared ultrastructural features of NAFLD in an animal model and in human samples of NAFLD patients. NAFLD animal model was obtained using Sprague Dawley rats fed by a high fat diet (HFD) (71% of energy from fat), while control rats were fed by a standard diet (35% of energy from fat). Diets were given ad libitum and rats were killed after 1, 2, 3, and 4 weeks. Human specimens were obtained from patients with fatty liver disease undergoing to liver biopsies. Normal liver was taken from patients undergoing surgery for other pathologies. Hepatic steatosis and normality of the liver were assessed by parallel examinations at light microscopy, transmission and high resolution scanning electron microscopy. Light microscopy results showed that different degrees of NAFLD observed in human samples corresponded to similar morphological changes in treated rats. Ultrastructural examination revealed that in the HFD model the histopathology closely reflected that of human NAFLD, although the first did not replicate the full spectrum of the disease in humans. In summary, we showed that, at least morphologically, HFD model overlays to human NAFLD. This could point out for reliability in evaluating other pathological features in animal models. Moreover, animal HFD mimics human nutritional dysregulation that may induce the same biochemical and molecular modifications observed in human patients and might represent a more appropriate tool for studying the pathogenesis of NAFLD over genetic models (2).
description: Italian Journal of Anatomy and Embryology, Vol 118, No 2 (Supplement) 2013