cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer
Creators: name: White, Cody A.
name: Rushing, Blake R.
name: Li, Yuan-Yuan
name: Partridge, Megan C.
name: Barker, Natalie K.
name: Pathmasiri, Wimal
name: Graves, Lee M.
name: Aponte-Collazo, Lucas J.
name: Iwanowicz, Edwin J.
name: Greer, Yoshimi E.
name: Fennell, Emily M. J.
name: Sumner, Susan C. J.
name: Herring, Laura E.
name: Lipkowitz, Stanley
Publisher: name: Frontiers Media S.A.
Year: 2023

description: ClpP activators ONC201 and related small molecules (TR compounds, Madera Therapeutics), have demonstrated significant anti-cancer potential in vitro and in vivo studies, including clinical trials for refractory solid tumors. Though progress has been made in identifying specific phenotypic outcomes following ClpP activation, the exact mechanism by which ClpP activation leads to broad anti-cancer activity has yet to be fully elucidated. In this study, we utilized a multi-omics approach to identify the ClpP-dependent proteomic, transcriptomic, and metabolomic changes resulting from ONC201 or the TR compound TR-57 in triple-negative breast cancer cells. Applying mass spectrometry-based methods of proteomics and metabolomics, we identified ∼8,000 proteins and 588 metabolites, respectively. From proteomics data, 113 (ONC201) and 191 (TR-57) proteins significantly increased and 572 (ONC201) and 686 (TR-57) proteins significantly decreased in this study. Gene ontological (GO) analysis revealed strong similarities between proteins up- or downregulated by ONC201 or TR-57 treatment. Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). Less than 21% of these genes were affected by these compounds in ClpP null cells. GO analysis of these data demonstrated additional similarity of response to ONC201 and TR-57, including a decrease in transcripts related to the mitochondrial inner membrane and matrix, cell cycle, and nucleus, and increases in other nuclear transcripts and transcripts related to metal-ion binding. Comparison of response between both compounds demonstrated a highly similar response in all -omics datasets. Analysis of metabolites also revealed significant similarities between ONC201 and TR-57 with increases in α-ketoglutarate and 2-hydroxyglutaric acid and decreased ureidosuccinic acid, L-ascorbic acid, L-serine, and cytidine observed following ClpP activation in TNBC cells. Further analysis identified multiple pathways that were specifically impacted by ClpP activation, including ATF4 activation, heme biosynthesis, and the citrulline/urea cycle. In summary the results of our studies demonstrate that ONC201 and TR-57 induce highly similar and broad effects against multiple mitochondrial processes required for cell proliferation.
The L1 cell adhesion molecule constrains dendritic spine density in pyramidal neurons of the mouse cerebral cortex
Creators: name: Pak, Yubin
name: Maness, Patricia F.
name: Wade, Sarah D.
name: Mohan, Vishwa
name: Murphy, Kelsey E.
name: Duncan, Bryce W.
name: Schachner, Melitta
name: Lutz, David
name: Zhang, Erin Y.
name: Sperringer, Justin E.
Publisher: name: Frontiers Media S.A.
Year: 2023

description: A novel function for the L1 cell adhesion molecule, which binds the actin adaptor protein Ankyrin was identified in constraining dendritic spine density on pyramidal neurons in the mouse neocortex. In an L1-null mouse mutant increased spine density was observed on apical but not basal dendrites of pyramidal neurons in diverse cortical areas (prefrontal cortex layer 2/3, motor cortex layer 5, visual cortex layer 4. The Ankyrin binding motif (FIGQY) in the L1 cytoplasmic domain was critical for spine regulation, as demonstrated by increased spine density and altered spine morphology in the prefrontal cortex of a mouse knock-in mutant (L1YH) harboring a tyrosine (Y) to histidine (H) mutation in the FIGQY motif, which disrupted L1-Ankyrin association. This mutation is a known variant in the human L1 syndrome of intellectual disability. L1 was localized by immunofluorescence staining to spine heads and dendrites of cortical pyramidal neurons. L1 coimmunoprecipitated with Ankyrin B (220 kDa isoform) from lysates of wild type but not L1YH forebrain. This study provides insight into the molecular mechanism of spine regulation and underscores the potential for this adhesion molecule to regulate cognitive and other L1-related functions that are abnormal in the L1 syndrome.
Zyxin contributes to coupling between cell junctions and contractile actomyosin networks during apical constriction
Creators: name: Cupp, Timothy D.
name: Zhang, Pu
name: Wong, Terrence
name: Higgins, Christopher D.
name: Prakash, Mangal
name: Tintori, Sophia C.
name: Bowie, Emily
name: Jug, Florian
name: Chen, Alicia H.
name: Goldstein, Bob
name: Slabodnick, Mark M.
Publisher: name: Public Library of Science
Year: 2023

description: One of the most common cell shape changes driving morphogenesis in diverse animals is the constriction of the apical cell surface. Apical constriction depends on contraction of an actomyosin network in the apical cell cortex, but such actomyosin networks have been shown to undergo continual, conveyor belt-like contractions before the shrinking of an apical surface begins. This finding suggests that apical constriction is not necessarily triggered by the contraction of actomyosin networks, but rather can be triggered by unidentified, temporally-regulated mechanical links between actomyosin and junctions. Here, we used C. elegans gastrulation as a model to seek genes that contribute to such dynamic linkage. We found that α-catenin and β-catenin initially failed to move centripetally with contracting cortical actomyosin networks, suggesting that linkage is regulated between intact cadherin-catenin complexes and actomyosin. We used proteomic and transcriptomic approaches to identify new players, including the candidate linkers AFD-1/afadin and ZYX-1/zyxin, as contributing to C. elegans gastrulation. We found that ZYX-1/zyxin is among a family of LIM domain proteins that have transcripts that become enriched in multiple cells just before they undergo apical constriction. We developed a semi-automated image analysis tool and used it to find that ZYX-1/zyxin contributes to cell-cell junctions’ centripetal movement in concert with contracting actomyosin networks. These results identify several new genes that contribute to C. elegans gastrulation, and they identify zyxin as a key protein important for actomyosin networks to effectively pull cell-cell junctions inward during apical constriction. The transcriptional upregulation of ZYX-1/zyxin in specific cells in C. elegans points to one way that developmental patterning spatiotemporally regulates cell biological mechanisms in vivo. Because zyxin and related proteins contribute to membrane-cytoskeleton linkage in other systems, we anticipate that its roles in regulating apical constriction in this manner may be conserved.
Beyond Anderson Localization in 1D: Anomalous Localization of Microwaves in Random Waveguides
Creators: name: Fernández-Marín, A. A.
name: Méndez-Bermúdez, J. A.
name: Carbonell, J.
name: Cervera, F.
name: Sánchez-Dehesa, J.
name: Gopar, V. A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Experimental evidence demonstrating that anomalous localization of waves can be induced in a controllable manner is reported. A microwave waveguide with dielectric slabs randomly placed is used to confirm the presence of anomalous localization. If the random spacing between slabs follows a distribution with a power-law tail (Lévy-type distribution), unconventional properties in the microwave-transmission fluctuations take place revealing the presence of anomalous localization. We study both theoretically and experimentally the complete distribution of the transmission through random waveguides characterized by $α=1/2$ ("Lévy waveguides") and $α=3/4$, $α$ being the exponent of the power-law tail of the Lévy-type distribution. As we show, the transmission distributions are determined by only two parameters, both of them experimentally accessible. Effects of anomalous localization on the transmission are compared with those from the standard Anderson localization.
description: 5 pages, 4 figures. Revised version as published"
ENHANCEMENT OF SOLUBILITY AND DISSOLUTION OF CARVEDILOL BY SOLID DISPERSION TECHNIQUE
Creators: name: Amale lalaso Shankar , Devara Raj kumar
Publisher: name: Zenodo
Year: 2023

description: Despite significant advancements in the science of drug delivery, solubilization of poorly aqueous soluble drugs still remains a challenging task for formulation. The purpose of the study was to improve the physicochemical properties of poorly aqueous soluble drug Carvedilol like solubility, dissolution properties and stability of poorly soluble drug by forming dispersion with skimmed milk powder as carrier. Carvedilol was formulated by solid dispersions using rota-evaporation method and lyophilization method in different ratios 1:1 to 1:12 of drug and carrier (skimmed milk powder). The formulations were evaluated for various in vitro parameters (Drug content, Drug release, phase solubility studies, dissolution efficiency, FTIR) as well as changes in the physical state during storage under different humidity conditions.  In vitro dissolution showed that increment of dissolution rate in case of SD than pure drug. Carevdilol phosphate with skimmed milk (1:6) showed the better results, maximum amount of drug released within 7 hours. It observed that no change in structure but change in physical state of the drug from crystalline to amorphous. The IR spectra of the drug, skimmed milk and the solid dispersion were performed to detect the possible molecular interaction between drug and carrier. The all above characteristics peaks of drug appear in the spectra of all ternary system at same wave number no modification or no interaction of the drug and carrier.
Keywords: Carvedilol, Solid dispersions, Skimmed milk, Carrier, FTIR, in-vitro release.
XPOL-III: a New-Generation VLSI CMOS ASIC for High-Throughput X-ray Polarimetry
Creators: name: Minuti, M.
name: Baldini, L.
name: Bellazzini, R.
name: Brez, A.
name: Ceccanti, M.
name: Krummenacher, F.
name: Latronico, L.
name: Lucchesi, L.
name: Manfreda, A.
name: Orsini, L.
name: Pinchera, M.
name: Profeti, A.
name: Sgr`o, C.
name: Spandre, G.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: While the successful launch and operation in space of the Gas Pixel Detectors onboard the PolarLight cubesat and the Imaging X-ray Polarimetry Explorer demonstrate the viability and the technical soundness of this class of detectors for astronomical X-ray polarimetry, it is clear that the current state of the art is not ready to meet the challenges of the next generation of experiments, such as the enhanced X-ray Timing and Polarimetry mission, designed to allow for a significantly larger data throughput. In this paper we describe the design and test of a new custom, self-triggering readout ASIC, dubbed XPOL-III, specifically conceived to address and overcome these limitations. While building upon the overall architecture of the previous generations, the new chip improves over its predecessors in several, different key areas: the sensitivity of the trigger electronics, the flexibility in the definition of the readout window, as well as the maximum speed for the serial event readout. These design improvements, when combined, allow for almost an order of magnitude smaller dead time per event with no measurable degradation of the polarimetric, spectral, imaging or timing capability of the detector, providing a good match for the next generation of X-ray missions.
description: accepted for publication at Nuclear Inst. and Methods in Physics Research Section A
The Impact of ICT on Knowledge Sharing Obstacles in Knowledge Management Process (Including Case-Study)
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2016

description: Today, knowledge is known as a valuable asset in any organization so management of such insensible asset is one of the factors cause success in organizations. But knowledge can be effective when it is shared across the organization. Therefore, knowledge sharing is a key element in the process of knowledge management. However, the role of inhibiting factors on knowledge sharing process in organizations cannot be denied. This study aimed to check the impact of ICT on knowledge sharing barriers in one of the mobile operator, in Tehran. In order to do this descriptive- illative study, after assessing the barriers of knowledge sharing and classified them into three categories: organizational, technological and individual and preparing the questionnaire according such information, from 900 staff of the headquarters of the organization, 500 members were selected randomly and asked about the obstacles regarding knowledge sharing and the impact of ICT in solving these problems. After collecting the answers, numerous results were obtained with the use of charts and tables. The results indicate the existence of a positive relationship between the impact of ICT on barriers to sharing knowledge in the knowledge management process, as 75% in the case of institutional barriers, 62% on individual problems of knowledge sharing and ultimately 66 % regarding technological barriers, ICT was able to contribute to solving problems.
Development of an Anti-Idiotype Aptamer-Based Electrochemical Sensor for a Humanized Therapeutic Antibody Monitoring
Creators: name: Sode, Koji
name: Saito, Taro
name: Lee, Jinhee
name: Ikebukuro, Kazunori
name: Nagata, Madoka
Publisher: name: MDPI
Year: 2023

description: Therapeutic monoclonal antibodies (mAbs) are currently the most effective medicines for a wide range of diseases. Therefore, it is expected that easy and rapid measurement of mAbs will be required to improve their efficacy. Here, we report an anti-idiotype aptamer-based electrochemical sensor for a humanized therapeutic antibody, bevacizumab, based on square wave voltammetry (SWV). With this measurement procedure, we were able to monitor the target mAb within 30 min by employing the anti-idiotype bivalent aptamer modified with a redox probe. A fabricated bevacizumab sensor achieved detection of bevacizumab from 1–100 nM while eliminating the need for free redox probes in the solution. The feasibility of monitoring biological samples was also demonstrated by detecting bevacizumab in the diluted artificial serum, and the fabricated sensor succeeded in detecting the target covering the physiologically relevant concentration range of bevacizumab. Our sensor contributes to ongoing efforts towards therapeutic mAbs monitoring by investigating their pharmacokinetics and improving their treatment efficacy.
An Investigation into the Relationship between Knowledge Management Infrastructures and Organizational Intelligence in Research Centers of the Ministry of Science, Research and Technology
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2016

description: Investigating the relationship between Knowledge Management Infrastructures and Organizational Intelligence in two research centers of Ministry of Science, Research and Technology namely Iranian Research Institute for Information Science and Technology and Institute for Humanities and Cultural Studies. The research is a survey in descriptive manner. Using two validated questionnaires related to Knowledge Management Infrastructures and Organizational Intelligence, the research was conducted among 175 faculty members and staffs of two research centers. Collected data were then analyzed by software SPSS and PLS. Factor analysis showed a high factor loading related to the two main variables and all of the items indicated goodness of fit of the questions. Variance mean ratio between two variables was higher than 0.5 indicating a high convergent validity. R Squares for Organizational Intelligence showed fitness of structural equating model. Goodness of fit for Iranian Research Institute for Information Science and Technology was 0.642 lower than Institute for Humanities and Cultural Studies with 0.645. Path analysis indicated a significant relationship between two variables by 95% degree of confidence accepting the two research hypothesis. By comparison, Knowledge Management Infrastructures was more correlated with Organizational Intelligence in Institute for Humanities and Cultural Studies than Iranian Research Institute for Information Science and Technology. Knowledge management Infrastructures in Iranian Research Institute for Information Science and Technology predicted Organizational Intelligence by 0.826 percent while in the Institute for Humanities and Cultural Studies by 0.848 percent.
Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells
Creators: name: Beck, Michael T.
name: Smith, Jeffery L.
name: Yang, Xuan
name: Willson, Timothy M.
name: Vasta, James D.
name: Michaud, Ani
name: Wilkinson, Jennifer M.
name: Robers, Matthew B.
Publisher: name: MDPI
Year: 2023

description: PLK1 is a protein kinase that regulates mitosis and is both an important oncology drug target and a potential antitarget of drugs for the DNA damage response pathway or anti-infective host kinases. To expand the range of live cell NanoBRET target engagement assays to include PLK1, we developed an energy transfer probe based on the anilino-tetrahydropteridine chemotype found in several selective PLK inhibitors. Probe 11 was used to configure NanoBRET target engagement assays for PLK1, PLK2, and PLK3 and measure the potency of several known PLK inhibitors. In-cell target engagement for PLK1 was in good agreement with the reported cellular potency for the inhibition of cell proliferation. Probe 11 enabled the investigation of the promiscuity of adavosertib, which had been described as a dual PLK1/WEE1 inhibitor in biochemical assays. Live cell target engagement analysis of adavosertib via NanoBRET demonstrated PLK activity at micromolar concentrations but only selective engagement of WEE1 at clinically relevant doses.
Study the content relationship between science and technology documents: A compression of papers and patent in Autonomous Underwater Vehicle Dominos
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2016

description: The current research aims at studying the conceptual relationship between the science and technology documents through the comparison of vocabularies that are used within the patents and the papers in the field of Autonomous Underwater Vehicles (AUV).  The research method is descriptive. To perform the research, the patents were retrieved from Google Patents and Lens websites, and the papers from IEEE Explore database. A hybrid keyword-class method was used to conduct the search. It means that the search query was consisted of "Autonomous Underwater Vehicle" keyword and “H” class. The titles and the abstracts of the patents and the papers were automatically indexed through a semi-automatic method. This resulted in 195 keywords for patents and 114 ones for papers. Co-occurrence matrices of these two sets of keywords were created through RavarMatrix software. The hierarchical maps of keywords were drawn by SPSS. Findings show that 65 percent of papers’ keywords are those that occurred within the patents but 23 percent of patents’ keywords are similar to the papers’.  The structural comparison of patents and papers clustering’s also revealed that the structural proximity between patents and papers vocabularies is equal to zero. The other finding showed that the similarity between the members of ego networks of prominent keywords is for two cases zero and for others fewer than 15 percent except for the keyword “data”. It may be concluded that the science is affected by technology in the field of AUV.
The representational systems for object and agent in new world monkeys
Creators: name: Zhang, Da
Publisher: name: University of St Andrews
Year: 2021
Subjects: Object individuation
Squirrel monkey
Capuchin monkey
Causal agent

description: Representing the environment in its most basic components, namely objects and agents, is a fundamental feature of human cognition which we may share to different extents with nonhuman animals. This thesis explored some manifestations of these abilities in two new world monkey species, squirrel monkeys and capuchin monkeys. We first investigated squirrel monkeys’ ability of individuating object by spatiotemporal and property/kind information with a “magic box” paradigm using both manual search and looking time measures (chapter 2). The squirrel monkeys failed both tasks with both measures, whereas capuchin monkeys showed individuating competence with exactly the same tasks and apparatus in a previous study. Chapter 3 tested and explored the possibility that squirrel monkeys failed the “magic box” tasks that capuchin monkeys passed because they acted so fast that they didn’t form or use this type of object representations to guide their actions. In fact, in a touchscreen-based object tracking/catching game (Whack-a-cricket task), the squirrel monkeys were slower to “catch” a moving “cricket” compared to capuchin monkeys. In chapter 4, we tested squirrel monkeys with another individuation task that included two separate barriers instead of a single box. The squirrel monkeys preferred to search the last- visited-location first when either spatiotemporal or property/kind information suggested that only one object was present. This preference disappeared when either information indicated that there were two objects, one behind each barrier. We conclude that squirrel monkeys are therefore able to individuate objects using both kinds of information when tested with an appropriate task. In the last chapter, we investigated whether capuchin monkeys can locate a causal agent based on an event that he initiated from a hidden location. Capuchin monkeys located the hidden agent when they saw an object pushed, raked, rolled, or thrown across a table seemingly by the experimenter behind one of two screens (agentive trials), but not when they saw an object roll down a ramp or fall off a block after a shake of the table (arbitrary control trials) that contained no information about the agent’ location. This result suggests capuchin monkeys can use motion events to infer the location of a causal agent, an ability also demonstrated by human infants. Taken together, our studies show that squirrel monkeys and capuchin monkeys have some core abilities to represent some of the fundamental properties of objects and agents, comparable to those demonstrated by human infants, which supports the core knowledge view that such representational systems may have a long evolutionary history and exist widely in primates.
Introducing a probabilistic–structural method for grapheme-to-phoneme conversion in Persian
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2016

description: Persian writing system deviates from the ideal one due to the lack of one-to-one correspondence between graphemes and phonemes. The present study deals with this question that in spite of the absence of short vowels in Persian writing system and one-to-many and many-to-one relationships between the graphemes and phonemes, how can Persian speakers read out of vocabulary words? This study introduces a probabilistic- structural method that Persian speakers use to read out of vocabulary words in which structural information (including Persian morphology and morphophonemic rules) as well as Arabic morphological templates are considered. In order to test how the introduced method works, Persian speakers were asked to read a list of out of vocabulary words. The mentioned list was used by ID3 and MLP (two methods which are used in machine learning) as input, then the outputs of the method and those of ID3 and MLP were compared with Persian speakers` pronunciations the results proved that the introduced method functions similar to Persian speakers in reading out of vocabulary words.
Evidence-based policy-making and the role of statistics and information
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2016

description: The ultimate goals of policy-making would not be possible by use of the methods such as surveys. Evidence-based policy-making is a new approach in the public policy which has increased in many countries. Evidence-based policy-making is based on the assumption that decisions should be based on available evidence and rational analysis in addition to the judgments and opinions. one of the important evidence is statistics. The accuracy statistics can promote the accuracy, quality and capacity of policy. According to the importance of the statistics for the evidence-based policy-making, this paper is seeking to examine the importance of the statistics for evidence-based policy-making and tiring to show that the correct and efficient use of statistics leads to better policy. This paper uses the mixed method for this purpose. The mixed method approach used in this paper is the sequential exploratory design that the qualitative data followed by the quantitative data are collected and analysed. First, the comprehensive process framework for evidence-based policy-making is developed in the qualitative part by using meta-synthesis. Second, in the quantitative part, binomial test is used to validation of the developed framework. The data collection tool is a questionnaire and has been completed by 15 experts in the field of policy-making. Finally, the paper examines the role of information and statistics in the steps of proposed framework.
Childhood Adversity Moderates Change in Latent Patterns of Psychological Adjustment during the COVID-19 Pandemic: Results of a Survey of U.S. Adults
Creators: name: Porges S.W.
name: Tomlinson C.A.
name: Applebaum J.W.
name: Brown S.
name: Matijczak A.
name: McDonald S.E.
name: Zsembik B.A.
name: Murphy J.L.
name: O’Connor K.E.
Publisher: name: MDPI
Year: 2023

description: Emerging evidence suggests that the consequences of childhood adversity impact later psychopathology by increasing individuals’ risk of experiencing difficulties in adjusting to stressful situations later in life. The goals of this study were to: (a) identify sociodemographic factors associated with subgroups of psychological adjustment prior to and after the onset of the COVID-19 pandemic and (b) examine whether and to what extent types of childhood adversity predict transition probabilities. Participants were recruited via multiple social media platforms and listservs. Data were collected via an internet-based survey. Our analyses reflect 1942 adults (M = 39.68 years); 39.8% reported experiencing at least one form of childhood adversity. Latent profile analyses (LPAs) and latent transition analyses (LTAs) were conducted to determine patterns of psychological adjustment and the effects of childhood adversity on transition probabilities over time. We identified five subgroups of psychological adjustment characterized by symptom severity level. Participants who were younger in age and those who endorsed marginalized identities exhibited poorer psychological adjustment during the pandemic. Childhood exposure to family and community violence and having basic needs met as a child (e.g., food, shelter) significantly moderated the relation between latent profile membership over time. Clinical and research implications are discussed.
An Assessment of Iranian Journals guide for authors
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2016

description: One indicator to assess the journals in international studies is the quality of guide for authors. The aim of this study is to determine the quality of guide for authors in Iranian journals.The population consisted of 755 Persian journals approved by Ministry of Science, Research and Technology in March 2013. Using a checklist, authors reviewed separately the content of guide for authors of 501 journals that provided access to their guide for authors through the web.according to the results, a total of 40% of the observed items were met. In addition, of the four studied sections, including generalities, legal and ethical issues, article structure and appearance, legal and ethical issues (18%) and appearance (56%) had the worst and best status respectively. In terms of the severity of problems, "violation of individuals or group rights"," how to write abbreviations and acronyms", "accepting journal requirements and laws", and "writing manuals used by authors" had the highest severity rankings.
Expertise Retrieval: Foundations, Methods and Models
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2016

description: Objective: Expertise Retrieval is defined as finding experts in different subject areas as well as identifying people expertise area(s). For almost two decades, ER within knowledge-based environments has attracted attention of large and medium organizations. It has given rise to a strong community of researchers, especially in Computer and Information Science. It seems, however, that ER has remained neglected among Iranian researchers. So, addressing the foundations, methods and models of ER, current paper intends to take step in making scientific community and organization mangers familiar with main concepts of this area. Methodology: This paper is an opinion paper based on library method. Findings: Supporting Knowledge Management is an important application of ER systems. In these systems, by avoiding the challenging characteristics of expertise concept, researchers simplify the problem of ER and limit its scope to textual documents accumulation and discovering of documents-persons associations. Several models have been presented for discovering of above-mentioned associations, among which Balog’s models had important role in promotion of ER field. document-centric model offered by Balog and his colleagues, is one of the most successful models that is the basis for subsequent models. Originality/Value: this paper addresses the issue of Expertise Retrieval and its Foundations, methods and Models. So, it could be of interest to information professionals, Information Retrieval area researchers, large and medium organization’s managers, and other knowledge-based environments.
Analysis and Comparison of Interdisciplinary Relations of Library Science and Information Science Based on Citation Clustering in The Period of Before and After the Appearance of the Web
Publisher: name: Iranian Research Institute for Information Science and Technology (IranDoc)
Year: 2016

description: The purpose of the present study was to analyze the interdisciplinary relations of “Library Science and Information Science”. For this purpose the subject categories of citing and cited journals of these fields were investigated in JCR database during the period of 1987-1997 and 2003-2013, and through the comparsion of obtained results the impact of information technology on the development of “LIS” interdisciplinarity was investigated. Methedology of the research was co-citation analysis of journals in scientometrics studies. Also the research was performed using the conventional techniques of scientometrics including Bradford law, Ward hierarchical clustering approach in statistical software SPSS, and the new measure including Proximity index. Research community includes citing and cited journals of 56 “LIS” journals during 1987-1997 and 83 journals during 2003-2013 in Journals Ctiation Report (JCR) database. The results showed that “LIS” has been influenced by other subject categories more than affecting them. For example, the number of journals which “LIS” cited from 1758 (in the first period) has increased to 5303 (in the second period). Co-occurrence matrix of core citing and cited subject categories was analyzed, and three main clusters in the first period and seven clusters in the second period were drawn. In general, the amount and quality of co-occurrence of subject categories in clusters showed that the domain and variety of affecting and affected subject categories were expanded in the second period. Structural similarity of clusters for affecting and affected subject categories calculated. Results showed that structural similarity of clusters in the second period was %10 higher than in the first period. Also, the Structural similarity of affecting clusters of “LIS” was more than affected clusters. Assessment of difference between subject categories groups by ANOVA and Tukey Post hoc tests showed that there were differences between all numbers of citing and cited groups.
Exploiting stellar explosion induced by the QCD phase transition in large-scale neutrino detectors
Creators: name: Pitik, Tetyana
name: Heimsoth, Daniel
name: Suliga, Anna M.
name: Balantekin, A. B.
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The centers of the core-collapse supernovae are one of the densest environments in the Universe. Under such conditions, it is conceivable that a first-order phase transition from ordinary nuclear matter to the quark-gluon plasma occurs. This transition releases a large amount of latent heat that can drive a supernova explosion and may imprint a sharp signature in the neutrino signal. We show how this snap feature, if observed at large-scale neutrino detectors, can set competitive limits on the neutrino masses and assist the localization of the supernova via triangulation. The 95\%C.L. limit on the neutrino mass can reach 0.16~eV in Ice-Cube, 0.22~eV in Hyper-Kamiokande, and 0.58~eV in DUNE, for a supernova at a distance of 10 kpc. For the same distance and in the most optimistic neutrino conversion case, the triangulation method can constrain the $1σ$ angular uncertainty of the supernova localization within $\sim 0.3^{\circ}-9.0^{\circ}$ in the considered pairs of the detectors, leading to an improvement up to an order of magnitude with respect to the often considered in the literature rise time of the neutronization burst.
description: 19 pages, 9 figures, 3 appendices. Minor clarifications added, matches version published in Phys. Rev. D
RISPERIDONE LIQUISOLID COMPACTS–FORMULATION AND EVALUATION
Creators: name: Kulkarni Rupanjali , Devara Raj kumar
Publisher: name: Zenodo
Year: 2023

description: Risperidone is an atypical antipsychotic agent used for serious brain illness like schizophrenia. However low aqueous solubility of this risperidone leads to its lower dissolution and thus lower bioavailability. Therefore, the development of risperidone liquisolid compacts was done with an aim to improve its dissolution rate via increasing the solubility of the drug. This results in improvement of its oral bioavailability. Aim of the present study was to augment the dissolution rate of Risperidone, thus increasing the oral bioavailability of poorly soluble drug. Preformulation studies like flow properties. The Fourier Transform Infrared spectroscopy (FTIR) results revealed that, there was no interaction among excipients (carrier, coating material, non-volatile solvent), and the drug risperidone. In-vitro drug dissolution studies showed improved in drug release of risperidone compared to pure drug. So, PEG 400, PG could be economic substitute as dissolution enhancing agent. It was determined that first order kinetics provided the greatest fit for the release data based on mathematical information obtained from models. The diffusion-controlled release mechanism is described by the Higuchi equation; the risperidone compacts' diffusion exponent indicating non-Fickian diffusion. Among PEG 400, PG, PEG 400 in 1:1 ratio with risperidone (F11, F12, F16, F17, F18) using carrier's spray dried lactose and syloid 244FP in ratio's of 10:1 and 20:1 with coating material aerosoil 200 was showing best results. F18 best among the successful formulations with highest drug release rate was compared with marketed preparation and results were better than marketed preparation.
Keywords: Risperidone, liquisolid compacts, FTIR, Carriers, Preformulation ,In-vitro drug release.
Options and market making
Creators: name: Machado Vieira, Douglas
Publisher: name: Imperial College London
Year: 2022

description: Options and market making are recurring themes in Mathematical Finance. This thesis explores both topics with the ultimate goal of developing an options market making model for exchange-traded vanilla options. We start the derivation of closed-form optimal controls for an asset-agnostic market making model with multiple assets via an ergodic limit. We then investigate the intraday dynamics of options and its connection with spot volatility to gain insights on the high-frequency option price dynamics and on volatility and Greeks estimation. Finally, we develop a market making model for exchange-traded vanilla options that encompasses relevant features that we observe empirically. Closed-form solutions for the options market making model can be obtained via small time-to-horizon asymptotics. The optimal spreads in the small time-to-horizon regime allow us to empirically study options spreads and trading activity.
Greenspace exposure and the retinal microvasculature in healthy adults across three European cities (unedited version)
Creators: name: Int Panis, Luc
name: Bauwelinck, Mariska
Publisher: name: Zenodo
Year: 2024

description: Background: Emerging evidence points to the beneficial role of greenspace exposure in promoting cardiovascular health. Most studies have evaluated such associations with conventional cardiovascular endpoints such as mortality, morbidity, or macrovascular markers. In comparison, the microvasculature, a crucial compartment of the vascular system where early subclinical signs of cardiovascular problems appear, has not been studied in association with greenspace exposure. The current study assessed the association between surrounding greenness and microvascular status, as assessed by retinal vessel diameters. Methods: This study included a sample of healthy adults (n = 114 and 18­65 years old) residing in three Eu ropean cities [Antwerp (Belgium), Barcelona (Spain), and London (UK)]. The exposures to greenspace at the home and work/school locations were characterized as average surrounding greenness [normalized difference vegetation index (NDVI)] within buffers of 100 m, 300 m, and 500 m. The central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were calculated from fundus pictures taken at three different time points. We developed linear mixed-effect models to estimate the association of greenspace exposure with indicators of retinal microvasculature, adjusted for relevant individual and area-level covariates. Results: We observed the most robust associations with CRVE. Higher levels of greenspace at work/school were associated with smaller retinal venules [(seasonal NDVI) 300m: 3.85, 95%CI -6.67,-1.03; 500m: 5.11, 95%CI -8.04, - 2.18]. Findings for surrounding greenness and CRAE were not conclusive. Conclusion: Our study suggests an association of greenspace exposure with better microvascular status, specif ically for retinal venules. Future research is needed to confirm our findings across different contextual settings.
INCORPORATION OF GAS PHASE ION/ION REACTION CHEMISTRIES AND ION PARKING INTO NATIVE MASS SPECTROMETRY
Creators: name: Pizzala, Nicolas Josef
Publisher: name: Purdue University Graduate School
Year: 2025
Subjects: classificationCode: 340101
subject: Analytical spectrometry
classificationCode: 340105
subject: Instrumental methods (excl. immunological and bioassay methods)
classificationCode: 340199
subject: Analytical chemistry not elsewhere classified

description: Production of multiply-charged ions, a hallmark of electrospray ionization, is advantageous for mass determination; however, for larger native complexes, closely spaced and overlapping charge states lead to congested mass spectra, hindering mass analysis. Furthermore, native ion signal can be distributed across multiple charge states, thereby reducing signal levels for the tandem mass spectrometry of any given charge state. Charge reduction via proton transfer reaction can reduce spectral overlap, and ion parking of a product ion can concentrate signal to fewer charge states. Subsequent ion-ion reactions can further reduce the charge, facilitating mass determination. Since ions have a fundamental secular frequency of motion rooted to m/z and trapping conditions, an applied auxiliary AC frequency can accelerate ions with a certain degree of selectivity. When applied during a proton transfer ion/ion reaction, ions with a distribution of charge states can be concentrated into a single charge state in a process referred to as ‘ion parking’. In this dissertation, I provide a demonstration of charge reduction strategies on proteins and protein complexes via proton transfer and multiply-charged ion attachment reactions. I also describe a general first-order forced-damped-harmonic-oscillator model for native ion parking in an electrodynamic quadrupole ion trap using a single supplementary dipolar AC frequency to inhibit the ion/ion reaction rate of a selected charge state of an analyte of interest. Lastly, I provide different applications combining proton transfer, ion parking, and then multiply-charged ion attachment to facilitate not only mass determination but also provide spectral separation of components from a mixture.
Higher order elliptic operators on variable domains. Stability results and boundary oscillations for intermediate problems
Creators: name: Arrieta, José M.
name: Lamberti, Pier Domenico
Publisher: name: arXiv
Year: 2015
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35J40, 35B20, 35B27, 35P15

description: We study the spectral behavior of higher order elliptic operators upon domain perturbation. We prove general spectral stability results for Dirichlet, Neumann and intermediate boundary conditions. Moreover, we consider the case of the bi-harmonic operator with those intermediate boundary conditions which appears in study of hinged plates. In this case, we analyze the spectral behavior when the boundary of the domain is subject to a periodic oscillatory perturbation. We will show that there is a critical oscillatory behavior and the limit problem depends on whether we are above, below or just sitting on this critical value. In particular, in the critical case we identify the strange term appearing in the limiting boundary conditions by using the unfolding method from homogenization theory.
description: New version with correction of a few misprints
Development and external validation of machine learning algorithms for postnatal gestational age estimation using clinical data and metabolomic markers
Creators: name: Rahman A.
name: Murphy M.S.Q.
name: Lamoureux M.
name: Wilson L.A.
name: Hawken S.
name: Denize K.M.
name: Pervin J.
name: Mwape H.
name: Chowdhury A.K.A.
name: Wilson K.
name: Olibris B.
name: Chakraborty P.
name: Rittenhouse K.J.
name: Vwalika B.
name: Henderson M.
name: Price J.T.
name: Cheng W.
name: Stringer J.S.A.
name: Ducharme R.
name: Potter B.K.
name: Bota A.B.
name: Little J.
name: Musonda P.
Publisher: name: Public Library of Science
Year: 2023

description: Background Accurate estimates of gestational age (GA) at birth are important for preterm birth surveillance but can be challenging to obtain in low income countries. Our objective was to develop machine learning models to accurately estimate GA shortly after birth using clinical and metabolomic data. Methods We derived three GA estimation models using ELASTIC NET multivariable linear regression using metabolomic markers from heel-prick blood samples and clinical data from a retrospective cohort of newborns from Ontario, Canada. We conducted internal model validation in an independent cohort of Ontario newborns, and external validation in heel prick and cord blood sample data collected from newborns from prospective birth cohorts in Lusaka, Zambia and Matlab, Bangladesh. Model performance was measured by comparing model-derived estimates of GA to reference estimates from early pregnancy ultrasound. Results Samples were collected from 311 newborns from Zambia and 1176 from Bangladesh. The best-performing model accurately estimated GA within about 6 days of ultrasound estimates in both cohorts when applied to heel prick data (MAE 0.79 weeks (95% CI 0.69, 0.90) for Zambia; 0.81 weeks (0.75, 0.86) for Bangladesh), and within about 7 days when applied to cord blood data (1.02 weeks (0.90, 1.15) for Zambia; 0.95 weeks (0.90, 0.99) for Bangladesh). Conclusions Algorithms developed in Canada provided accurate estimates of GA when applied to external cohorts from Zambia and Bangladesh. Model performance was superior in heel prick data as compared to cord blood data.
Global HI Properties of Galaxies via Super-profile Analysis
Creators: name: Kim, Minsu
name: Oh, Se-Heon
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present a new method which constructs an HI super-profile of a galaxy which is based on profile decomposition analysis. The decomposed velocity profiles of an HI data cube with an optimal number of Gaussian components are co-added after being aligned in velocity with respect to their centroid velocities. This is compared to the previous approach where no prior profile decomposition is made for the velocity profiles being stacked. The S/N improved super-profile is useful for deriving the galaxy's global HI properties like velocity dispersion and mass from observations which do not provide sufficient surface brightness sensitivity for the galaxy. As a practical test, we apply our new method to 64 high-resolution HI data cubes of nearby galaxies in the local Universe which are taken from THINGS and LITTLE THINGS. In addition, we also construct two additional HI super-profiles of the sample galaxies using symmetric and all velocity profiles of the cubes whose centroid velocities are determined from Hermite $h_3$ polynomial fitting, respectively. We find that the HI super-profiles constructed using the new method have narrower cores and broader wings in shape than the other two super-profiles. This is mainly due to the effect of either asymmetric velocity profiles' central velocity bias or the removal of asymmetric velocity profiles in the previous methods on the resulting HI super-profiles. We discuss how the shapes ($σ_{\rm{n}}/σ_{\rm{b}}$, $A_{\rm{n}}/A_{\rm{b}}$, and $A_{\rm{n}}/A_{\rm{tot}}$) of the new HI super-profiles which are measured from a double Gaussian fit are correlated with star formation rates of the sample galaxies and are compared with those of the other two super-profiles.
description: 24 pages, 13 figures, published in JKAS