cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Micromolar concentrations of hydrogen peroxide induce oxidative DNA lesions more efficiently than millimolar concentrations in mammalian cells
Creators: name: Swenberg, James A.
name: Nakamura, Jun
name: Purvis, Elizabeth R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Reactive oxygen species produce oxidized bases, deoxyribose lesions and DNA strand breaks in mammalian cells. Previously, we demonstrated that aldehydic DNA lesions (ADLs) were induced in mammalian cells by 10 mM hydrogen peroxide (H2O2). Interestingly, a bimodal H2O2 dose–response relationship in cell toxicity has been reported for Escherichia coli deficient in DNA repair as well as Chinese hamster ovary (CHO) cells. Furthermore, it has been demonstrated that H2O2 causes single-strand breaks in purified DNA in the presence of iron and induces mitochondrial DNA damage in CHO cells with a biphasic dose–response curve. Here we show that H2O2 produces ADLs at concentrations as low as 0.06 mM in HeLa cells and that lower concentrations of H2O2 were much more efficient at inducing ADLs than higher concentrations. This dose–response curve is strikingly similar to that for cell killing effects in E.coli deficient in DNA repair exposed to H2O2. Interestingly, serial treatment of submillimolar levels of H2O2 induced a massive accumulation of ADLs. The toxicity arising from H2O2 determined by intracellular NAD(P)H in cells correlated well with the formation of ADLs. The addition of dipyridyl, an iron (II)-specific chelator, significantly protected against DNA damage and cell toxicity from submillimolar, but not millimolar, amounts of H2O2. These results suggest that ADLs induced by submillimolar levels of H2O2 may be due to a Fenton-type reaction between H2O2 and intracellular iron ions in mammalian cells.
(400013) William Anderson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(400015) John Anderson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Quantitation of intracellular NAD(P)H can monitor an imbalance of DNA single strand break repair in base excision repair deficient cells in real time
Creators: name: Hester, Susan D.
name: Asakura, Shoji
name: de Murcia, Gilbert
name: Swenberg, James A.
name: Nakamura, Jun
name: Caldecott, Keith W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: DNA single strand breaks (SSBs) are one of the most frequent DNA lesions in genomic DNA generated either by oxidative stress or during the base excision repair pathways. Here we established a new real-time assay to assess an imbalance of DNA SSB repair by indirectly measuring PARP-1 activation through the depletion of intracellular NAD(P)H. A water-soluble tetrazolium salt is used to monitor the amount of NAD(P)H in living cells through its reduction to a yellow colored water-soluble formazan dye. While this assay is not a direct method, it does not require DNA extraction or alkaline treatment, both of which could potentially cause an artifactual induction of SSBs. In addition, it takes only 4 h and requires less than a half million cells to perform this measurement. Using this assay, we demonstrated that the dose- and time-dependent depletion of NAD(P)H in XRCC1-deficient CHO cells exposed to methyl methanesulfonate. This decrease was almost completely blocked by a PARP inhibitor. Furthermore, methyl methanesulfonate reduced NAD(P)H in PARP-1+/+cells, whereas PARP-1–/– cells were more resistant to the decrease in NAD(P)H. These results indicate that the analysis of intracellular NAD(P)H level using water-soluble tetrazolium salt can assess an imbalance of SSB repair in living cells in real time.
(400011) John Anderson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Enhancement of camptothecin-induced topoisomerase I cleavage complexes by the acetaldehyde adduct N2-ethyl-2'-deoxyguanosine
Creators: name: Pommier, Yves
name: Antony, Smitha
name: Brooks, P. J.
name: Lesher, Diem Thu
name: Theruvathu, Jacob A.
name: Redinbo, Matt
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: The activity of DNA topoisomerase I (Top1), an enzyme that regulates DNA topology, is impacted by DNA structure alterations and by the anticancer alkaloid camptothecin (CPT). Here, we evaluated the effect of the acetaldehyde-derived DNA adduct, N2-ethyl-2′-deoxyguanosine (N2-ethyl-dG), on human Top1 nicking and closing activities. Using purified recombinant Top1, we show that Top1 nicking-closing activity remains unaffected in N2-ethyl-dG adducted oligonucleotides. However, the N2-ethyl-dG adduct enhanced CPT-induced Top1–DNA cleavage complexes depending on the relative position of the N2-ethyl-dG adduct with respect to the Top1 cleavage site. The Top1-mediated DNA religation (closing) was selectively inhibited when the N2-ethyl-dG adduct was present immediately 3′ from the Top1 site (position +1). In addition, when the N2-ethyl-dG adduct was located at the −5 position, CPT enhanced cleavage at an alternate Top1 cleavage site immediately adjacent to the adduct, which was then at position +1 relative to this new alternate Top1 site. Modeling studies suggest that the ethyl group on the N2-ethyl-dG adduct located at the 5′ end of a Top1 site (position +1) sterically blocks the dissociation of CPT from the Top1–DNA complex, thereby inhibiting further the religation (closing) reaction.
Additional file 2 of Cardiac reverse remodeling in primary mitral regurgitation: mitral valve replacement vs. mitral valve repair
Creators: name: Craven, Thomas P.
name: Chew, Pei G.
name: Dobson, Laura E.
name: Gorecka, Miroslawa
name: Parent, Martine
name: Brown, Louise A. E.
name: Saunderson, Christopher E. D.
name: Das, Arka
name: Chowdhary, Amrit
name: Jex, Nicholas
name: Higgins, David M.
name: Dall’Armellina, Erica
name: Levelt, Eylem
name: Schlosshan, Dominik
name: Swoboda, Peter P.
name: Plein, Sven
name: Greenwood, John P.
Publisher: name: figshare
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology

description: Additional file 2. Subgroup analysis of surgical groups after exclusion of patients with moderate residual MR. Subgroup analysis of follow up cardiac, haemodynamic and functional indices between mitral valve repairand mitral valve replacement after excluding cases with at least moderate residual mitral regurgitation.
(400012) Elizabeth Low
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Figure S1 from Torpor reduces predation risk by compensating for the energetic cost of antipredator foraging behaviours.
Creators: name: Turbill, Christopher
name: Stojanovski, Lisa
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Figure S1 Model estimated partial effects on food consumption expressed as giving-up densities
Histone 3 lysine 4 methylation during the pre-B to immature B-cell transition
Creators: name: Perkins, Eric J.
name: Ramsden, Dale A.
name: Kee, Barbara L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: The relationship between chromatin modification and lymphocyte development is still poorly understood. Here we show a correlation between methylation of lysine 4 on histone 3 (H3-K4) and activation of several loci required for the pre-B cell to immature B-cell developmental transition. A critical step in this transition is the induction of V(D)J recombination at the Igκ locus. Upon activation of Igκ recombination, a >10-fold enrichment of both di- and trimethylated H3-K4 is observed at Jκ targeting signals, but not at an analogous targeting signal in the T-cell receptor α locus or, surprisingly, at several Vκ signals. However, H3-K4 methylation is restricted to the actively recombining fraction of Jκ recombination targeting signals, consistent with a direct relationship between H3-K4 methylation and signal activity. Correlations between increased H3-K4 methylation and induction of transcription are also observed at some, but not all, loci where transcription is induced. H3-K4 methylation may therefore be a widely used but not universal means for controlling chromatin activity in this developmental transition.
Asymmetric features in the protoplanetary disk MWC758
Creators: name: Benisty, M.
name: Juhasz, A.
name: Boccaletti, A.
name: Avenhaus, H.
name: Milli, J.
name: Thalmann, C.
name: Dominik, C.
name: Pinilla, P.
name: Buenzli, E.
name: Pohl, A.
name: Beuzit, J. -L.
name: Birnstiel, T.
name: de Boer, J.
name: Bonnefoy, M.
name: Chauvin, G.
name: Christiaens, V.
name: Garufi, A.
name: Grady, C.
name: Henning, T.
name: Huelamo, N.
name: Isella, A.
name: Langlois, M.
name: Menard, F.
name: Mouillet, D.
name: Olofsson, J.
name: Pantin, E.
name: Pinte, C.
name: Pueyo, L.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The study of dynamical processes in protoplanetary disks is essential to understand planet formation. In this context, transition disks are prime targets because they are at an advanced stage of disk clearing and may harbor direct signatures of disk evolution. In this paper, we aim to derive new constraints on the structure of the transition disk MWC 758, to detect non-axisymmetric features and understand their origin. We obtained infrared polarized intensity observations of the protoplanetary disk MWC 758 with SPHERE/VLT at 1.04 microns to resolve scattered light at a smaller inner working angle (0.093") and a higher angular resolution (0.027") than previously achieved. We observe polarized scattered light within 0.53" (148 au) down to the inner working angle (26 au) and detect distinct non-axisymmetric features but no fully depleted cavity. The two small-scale spiral features that were previously detected with HiCIAO are resolved more clearly, and new features are identified, including two that are located at previously inaccessible radii close to the star. We present a model based on the spiral density wave theory with two planetary companions in circular orbits. The best model requires a high disk aspect ratio (H/r~0.20 at the planet locations) to account for the large pitch angles which implies a very warm disk. Our observations reveal the complex morphology of the disk MWC758. To understand the origin of the detected features, the combination of high-resolution observations in the submillimeter with ALMA and detailed modeling is needed.
description: Accepted by A&A Letters
Understanding Cognitive Variability in Alzheimer’s Disease
Creators: name: Doherty, Thomas
Publisher: name: University of Westminster
Year: 2023

description: Alzheimer’s Disease (AD) is highly heterogenous, both clinically and biologically. This variability is exacerbated by the ways within which, the clinical presentation is assessed with cognitive measures. This inhibits clinical trial success and earlier diagnosis of individuals. Marrying the clinical presentation to the pathology of the disease has so far proved troublesome. This thesis will look at how cognitive measures can best capture the clinical presentation of AD and how these measures can link to the underlying pathology using machine learning methods. This thesis studied this problem across four analyses and two cohorts. Each study looked at a different aspect of cognitive testing within AD. This was done with the overarching aim to interrogate the cognitive variability across the spectrum of AD. Study 1 showed a novel discrepancy score is different to memory measures at screening for AD. It also showed it tracks with AD severity, in the same way memory recall does. Studies 2 & 3 uncovered broad psychometric variance within amnestic measurement of impairment due to AD. This was done in two different populations across two different constructs of amnestic measurement, story recall and verbal list learning. These tests are frequently used interchangeably. These two studies show they should not be. Finally, Study 4 built models from cognitive measures to predict AD pathology. The performance of these models was moderate showing that even with novel cognitive measures, further work is needed to link the clinical and amyloid related biological presentations of AD. Bridging the gap between clinical presentation and pathology of AD using clinical and cognitive markers alone is not possible. Even when using a novel measure of discrepancy score. The discrepancy measure shows promise but was limited due to the inability of the MMSE to measure verbal ability. Conceptually a discrepancy score remains a promising avenue of research for screening, but broader language measures, as well as other AD biomarkers are needed to further test the construct validity of this measure.
Additional file 3 of Cardiac reverse remodeling in primary mitral regurgitation: mitral valve replacement vs. mitral valve repair
Creators: name: Craven, Thomas P.
name: Chew, Pei G.
name: Dobson, Laura E.
name: Gorecka, Miroslawa
name: Parent, Martine
name: Brown, Louise A. E.
name: Saunderson, Christopher E. D.
name: Das, Arka
name: Chowdhary, Amrit
name: Jex, Nicholas
name: Higgins, David M.
name: Dall’Armellina, Erica
name: Levelt, Eylem
name: Schlosshan, Dominik
name: Swoboda, Peter P.
name: Plein, Sven
name: Greenwood, John P.
Publisher: name: figshare
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology

description: Additional file 3. Subgroup analysis with CABG patients excluded. Subgroup analysis comparing groups after exclusion of patients who underwent CABG: demonstrating the baseline patient characteristics (Table S3), baseline CMR parameters (Table S4), change in functional, haemodynamic and cardiac parameters from baseline to 6 month follow up assessment (Table S5) and residual functional, haemodynamic and cardiac parameters at 6 month follow up assessment (Table S6).
(400008) Hunter Lindsay Adamson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Inhibition of MDR1 gene expression by chimeric HNA antisense oligonucleotides
Creators: name: Fisher, Michael H.
name: Herdewijn, Piet
name: Kang, Hyunmin
name: Xu, Dong
name: Miyamoto, Yuko J.
name: Marchand, Arnaud
name: Juliano, Rudolph L.
name: Van Aerschot, Arthur
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Hexitol nucleic acids (HNAs) are nuclease resistant and provide strong hybridization to RNA. However, there is relatively little information on the biological properties of HNA antisense oligonucleotides. In this study, we compared the antisense effects of a chimeric HNA ‘gapmer’ oligonucleotide comprising a phosphorothioate central sequence flanked by 5′ and 3′ HNA sequences to conventional phosphorothioate oligonucleotides and to a 2′-O-methoxyethyl (2′-O-ME) phosphorothioate ‘gapmer’. The antisense oligomers each targeted a sequence bracketing the start codon of the message of MDR1, a gene involved in multi-drug resistance in cancer cells. Antisense and control oligonucleotides were delivered to MDR1-expressing cells using transfection with the cationic lipid Lipofectamine 2000. The anti-MDR1 HNA gapmer was substantially more potent than a phosphorothioate oligonucleotide of the same sequence in reducing expression of P-glycoprotein, the MDR1 gene product. HNA and 2′-O-ME gapmers displayed similar potency, but a pure HNA antisense oligonucleotide (lacking the phosphorothioate ‘gap’) was ineffective, indicating that RNase H activity was likely required. Treatment with anti-MDR1 HNA gapmer resulted in increased cellular accumulation of the drug surrogate Rhodamine 123 that correlated well with the reduced cell surface expression of P-glycoprotein. Thus, HNA gapmers may provide a valuable additional tool for antisense-based investigations and therapeutic approaches.
Strong converse exponents for the feedback-assisted classical capacity of entanglement-breaking channels
Creators: name: Ding, Dawei
name: Wilde, Mark M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Information Theory (cs.IT)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Quantum entanglement can be used in a communication scheme to establish a correlation between successive channel inputs that is impossible by classical means. It is known that the classical capacity of quantum channels can be enhanced by such entangled encoding schemes, but this is not always the case. In this paper, we prove that a strong converse theorem holds for the classical capacity of an entanglement-breaking channel even when it is assisted by a classical feedback link from the receiver to the transmitter. In doing so, we identify a bound on the strong converse exponent, which determines the exponentially decaying rate at which the success probability tends to zero, for a sequence of codes with communication rate exceeding capacity. Proving a strong converse, along with an achievability theorem, shows that the classical capacity is a sharp boundary between reliable and unreliable communication regimes. One of the main tools in our proof is the sandwiched Renyi relative entropy. The same method of proof is used to derive an exponential bound on the success probability when communicating over an arbitrary quantum channel assisted by classical feedback, provided that the transmitter does not use entangled encoding schemes.
description: 24 pages, 2 figures, v4: final version accepted for publication in Problems of Information Transmission
M�moire oblige. Riflessioni sull'opera di Primo Levi
Creators: name: Neiger, Ada
Publisher: name: Universit� di Trento. Dipartimento di Studi Letterari, Linguistici e Filologici
Year: 2009

description: Nella visione di Avishai Margalit, il testimone morale, scampato a un naufragio esistenziale, attinge alla propria esperienza, non vuole sprofondarla nell?oblio. Non smemorato, ma memorioso, cos� lo definirebbe Alberto Ca�vaglion, Primo Levi incarna la figura del testimone morale che si adopera per conservare le tracce del proprio vissuto e metterle al servizio della memoria collettiva. Attorno a questo superstite che � grande anche come poeta traduttore, novelliere, saggista e pubbli�cista, si intrecciano le riflessioni qui raccolte in volume.
Interaction of mitochondrial initiation factor 2 with mitochondrial fMet-tRNA
Creators: name: Spremulli, Linda L.
name: Spencer, Angela C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: The mammalian mitochondrial genome contains a single tRNAMet gene that gives rise to the initiator and elongator tRNAMet. It is generally believed that mitochondrial protein synthesis begins with formylmethionyl-tRNA, which indicates that the formylation of mitochondrial Met-tRNA specifies its participation in initiation through its interaction with initiation factor 2 (IF-2). However, recent studies in yeast mitochondria, suggest that formylation is not required for protein synthesis. In addition, bovine IF-2mt could replace yeast IF-2mt in strains that lack fMet-tRNA which suggests that this paradigm may extend to mammalian mitochondria. Here, the importance of the formylation of mitochondrial Met-tRNA for the interaction with IF-2mt was investigated by measuring the ability of bovine IF-2mt to bind mitochondrial fMet-tRNA. In direct binding experiments, bovine IF-2mt has a 25-fold greater affinity for mitochondrial fMet-tRNA than Met-tRNA, using either the native mitochondrial tRNAMet or an in vitro transcript of bovine mitochondrial tRNAMet. In addition, IF-2mt will not effectively stimulate mitochondrial Met-tRNA binding to mitochondrial ribosomes, exhibiting a 50-fold preference for fMet-tRNA over Met-tRNA in this assay. Finally, the region of IF-2mt responsible for the interaction with fMet-tRNA was mapped to the C2 sub-domain of domain VI of this factor.
Il prisma di Proteo: riscritture, ricodificazioni, traduzioni fra Italia e Spagna (sec.XVI-XVII)
Creators: name: Nider, Valentina
Publisher: name: Universit� degli Studi di Trento. Dipartimento di Scienze Filologiche e Storiche
Year: 2012

description: I saggi che qui si raccolgono nascono dalla convinzione che in epoca moderna i diversi livelli di riscrittura di un testo, dalla traduzione alla trasposizione intersemiotica, si inscrivano in una rete di relazioni complesse da indagare in una prospettiva interdisciplinare. La ricerca parte dalla constatazione che il panorama geografico e culturale di riferimento � fondamentalmente policentrico: oltre ai luoghi e istituzioni dell?Italia spagnola e all?asse che unisce Madrid e la curia romana, emerge l?importanza di altri centri di irraggiamento e di interconnessione, fra i quali spicca ovviamente Venezia, ma anche Firenze per il ruolo svolto nella sedimentazione del repertorio spagnolo in Italia. Ricordiamo fra le altre tre principali direttrici nell?indagine sottesa agli studi presentati: l?accento sulle relazioni biunivoche fra le letterature italiana e spagnola come contesto privilegiato in cui sorgono nuovi generi e contaminazioni che vanno ben al di l� dell?orizzonte del Siglo de Oro; lo studio delle traduzioni e adattamenti, condotto approfondendo sia la prospettiva linguistica e teorica sia il contesto storico ed editoriale e la presentazione di risultati che documentano un?attenzione pi� consapevole da parte del mondo editoriale italiano verso la letteratura spagnola dei Secoli d?Oro e la sua proiezione europea.
(400010) Christina [Ogilvie]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Figure S1 from Torpor reduces predation risk by compensating for the energetic cost of antipredator foraging behaviours
Creators: name: Turbill, Christopher
name: Stojanovski, Lisa
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Figure S1 Model estimated partial effects on food consumption expressed as giving-up densities
SLBP is associated with histone mRNA on polyribosomes as a component of the histone mRNP
Creators: name: Kaygun, Handan
name: Erkmann, Judith A.
name: Townley-Tilson, W. H.Davin
name: Whitfield, Michael L.
name: Dominski, Zbigniew
name: Marzluff, William F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: The stem–loop binding protein (SLBP) binds the 3′ end of histone mRNA and is present both in nucleus, and in the cytoplasm on the polyribosomes. SLBP participates in the processing of the histone pre-mRNA and in translation of the mature message. Histone mRNAs are rapidly degraded when cells are treated with inhibitors of DNA replication and are stabilized by inhibitors of translation, resulting in an increase in histone mRNA levels. Here, we show that SLBP is a component of the histone messenger ribonucleoprotein particle (mRNP). Histone mRNA from polyribosomes is immunoprecipitated with anti-SLBP. Most of the SLBP in cycloheximide-treated cells is present on polyribosomes as a result of continued synthesis and transport of the histone mRNP to the cytoplasm. When cells are treated with inhibitors of DNA replication, histone mRNAs are rapidly degraded but SLBP levels remain constant and SLBP is relocalized to the nucleus. SLBP remains active both in RNA binding and histone pre-mRNA processing when DNA replication is inhibited.
Additional file 4 of Cardiac reverse remodeling in primary mitral regurgitation: mitral valve replacement vs. mitral valve repair
Creators: name: Craven, Thomas P.
name: Chew, Pei G.
name: Dobson, Laura E.
name: Gorecka, Miroslawa
name: Parent, Martine
name: Brown, Louise A. E.
name: Saunderson, Christopher E. D.
name: Das, Arka
name: Chowdhary, Amrit
name: Jex, Nicholas
name: Higgins, David M.
name: Dall’Armellina, Erica
name: Levelt, Eylem
name: Schlosshan, Dominik
name: Swoboda, Peter P.
name: Plein, Sven
name: Greenwood, John P.
Publisher: name: figshare
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology

description: Additional file 4. Subgroup analysis of surgical groups—Comparison of baseline parameters of surgical patients when divided into groups by follow-up left ventricular ejection fraction. Subgroup analysis of surgical groups demonstrating baseline parameters between those achieving LVEF ≥ 50% vs LVEF < 50% at follow-up (Table S7).
La legge della scienza: nuovi paradigmi di disciplina dell'attivit� medico-scientifica. Uno studio comparato in materia di procreazione medicalmente assistita
Creators: name: Penasa, Simone
Publisher: name: Universit� degli studi di Trento
Year: 2015

description: L?opera propone un?analisi comparata della disciplina in materia di procreazione medicalmente assistita in quattro ordinamenti europei ? Italia, Francia, Regno Unito, Spagna ? al fine di proporre una modellistica dei diversi approcci normativi che il legislatore nazionale pu� assumere rispetto alla disciplina della attivit� medico-scientifica. La comparazione si fonda sulla selezione di una serie di indici, che integrano indici tradizionali, fondati sull?analisi del contenuto della legislazione, e indici di natura procedurale, finalizzati a determinare le caratteristiche del procedimento di approvazione e attuazione della legge, partendo dal presupposto che tali caratteristiche procedimentali incidano sui contenuti legislativi, in termini di legittimazione sociale, legittimit� costituzionale e adeguatezza scientifica.
(400007) Margaret Ann Adamson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Il Giudice di pace e la riforma della magistratura onoraria. Atti del Convegno. Trento, 3-4 dicembre 2015
Creators: name: Fornasari, Gabriele
name: Mattevi, Elena
Publisher: name: Universit� degli Studi di Trento
Year: 2017

description: Il presente volume raccoglie gli Atti del Convegno tenutosi a Trento, presso la Facolt� di Giurisprudenza, in data 3 e 4 dicembre 2015 sul tema ?Il giudice di pace e la riforma della magistratura onoraria?. Questa occasione di riflessione, frutto della collaborazione esistente tra l?Universit� degli Studi di Trento e la Regione Autonoma Trentino-Alto Adige/S?dtirol, � stata promossa in un momento assai delicato per la magistratura onoraria, essendo allora in discussione in Parlamento il Disegno di legge n. 1738, d?iniziativa governativa, esitato poi nella legge 28 aprile 2016, n. 57, contenente una riforma organica della magistratura onoraria e quindi anche della magistratura ?di pace?. Con l?analisi dei principi costituzionali in materia e dei modelli europei si tracciano nel volume le coordinate fondamentali delle considerazioni sulla magistratura onoraria che si sviluppano poi con pi� specifico riferimento alla figura del giudice di pace, fin dalla sua introduzione nel nostro ordinamento con competenza in materia civile e poi in materia penale. Diversi contributi hanno quindi ad oggetto il progetto di riforma, perfezionatosi nella legge che in massima parte coincide con il testo del disegno e che � stata considerata da tutti imprescindibile e di grande impatto, visto il numero dei magistrati onorari che operano nel sistema giudiziario.
Hawking radiation and secularly growing loop corrections
Creators: name: Akhmedov, Emil T.
name: Godazgar, Hadi
name: Popov, Fedor K.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We study the expectation value of the energy momentum tensor during thin shell collapse for a massive, real, scalar field theory. At tree-level, we find thermal, Hawking-type, behaviour for the energy flux. Using the Schwinger-Keldysh technique, we calculate two-loop corrections to the tree-level correlation functions and show that they exhibit secular growth, suggesting the breakdown of the perturbation theory.
description: 28 pages, but general physical explanation is given in the introduction; Final version that is going to appear in PRD
The human Rad9 checkpoint protein stimulates the carbamoyl phosphate synthetase activity of the multifunctional protein CAD
Creators: name: Wauson, Eric M.
name: Graves, Lee M.
name: Lindsey-Boltz, Laura A.
name: Sancar, Aziz
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: The human Rad9 checkpoint protein is a subunit of the heterotrimeric Rad9-Rad1-Hus1 (9-1-1) complex that plays a role as a damage sensor in the DNA damage checkpoint response. Rad9 has been found to interact with several other proteins outside the context of the 9-1-1 complex with no obvious checkpoint functions. During our studies on the 9-1-1 complex, we found that Rad9 immunoprecipitates contained a 240 kDa protein that was identified as carbamoyl phosphate synthetase/aspartate transcarbamoylase/dihydroorotase (CAD), a multienzymatic protein required for the de novo synthesis of pyrimidine nucleotides and cell growth. Further investigations revealed that only free Rad9, but not Rad9 within the 9-1-1 complex, bound to CAD. The rate-limiting step in de novo pyrimidine nucleotide synthesis is catalyzed by the carbamoyl phosphate synthetase II (CPSase) domain of CAD. We find that Rad9 binds to the CPSase domain, and, moreover, this binding results in a 2-fold stimulation of the CPSase activity of CAD. Similar results were also obtained with an N-terminal Rad9 fragment. These findings suggest that Rad9 may play a role in ribonucleotide biosynthesis.
The sea urchin stem-loop-binding protein: a maternally expressed protein that probably functions in expression of multiple classes of histone mRNA
Creators: name: Schnackenberg, Bradley J.
name: Howard, Jason T.
name: Coffman, James A.
name: Marzluff, William F.
name: Dominski, Zbigniew
name: Sumerel, Jan L.
name: Robertson, Anthony J.
name: McCarthy, John J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Following the completion of oogenesis and oocyte maturation, histone mRNAs are synthesized and stored in the sea urchin egg pronucleus. Histone mRNAs are the only mRNAs that are not polyadenylated but instead end in a stem–loop which has been conserved in evolution. The 3′ end binds the stem–loop-binding protein (SLBP), and SLBP is required for histone pre-mRNA processing as well as translation of the histone mRNAs. A cDNA encoding a 59 kDa sea urchin SLBP (suSLBP) has been cloned from an oocyte cDNA library. The suSLBP contains an RNA-binding domain that is similar to the RNA-binding domain found in SLBPs from other species, although there is no similarity between the rest of the suSLBP and other SLBPs. The suSLBP is present at constant levels in eggs and for the first 12 h of development. The levels of suSLBP then decline and remain at a low level for the rest of embryogenesis. The suSLBP is concentrated in the egg pronucleus and is released from the nucleus only when cells enter the first mitosis. SuSLBP expressed by in vitro translation does not bind the stem–loop RNA, suggesting that suSLBP is modified to activate RNA binding in sea urchin embryos.
Supplementary Information from Pathogen shifts in a honeybee predator following the arrival of the Varroa mite.
Creators: name: Loope, Kevin J.
name: Baty, James W.
name: Lester, Philip J.
name: Rankin, Erin E. Wilson
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: This file contains additional methods details, as well as the supplementary figures and tables.
(400009) William Ogilvie
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Bordered Floer homology and existence of incompressible tori in homology spheres
Creators: name: Eftekhary, Eaman
Publisher: name: arXiv
Year: 2015
Subjects: subject: Geometric Topology (math.GT)
subject: Symplectic Geometry (math.SG)
subject: FOS: Mathematics
subject: 57M27, 57R58

description: Let $K$ denote a knot inside the homology sphere $Y$. The zero-framed longitude of $K$ gives the complement of $K$ in $Y$ the structure of a bordered three-manifold, which may be denoted by $Y(K)$. We compute the quasi-isomorphism type of the bordered Floer complex of $Y(K)$ in terms of the knot Floer complex associated with $K$. As a corollary, we show that if a homology sphere has the same Heegaard Floer homology as $S^3$ it does not contain any incompressible tori. Consequently, if $Y$ is an irreducible homology sphere $L$-space then $Y$ is either $S^3$, or the Poicaré sphere $Σ(2,3,5)$, or it is hyperbolic.
Il teatro e la pietas = Theatre and Pietas
Creators: name: Rubino, Margherita
name: Pipino, K.
Publisher: name: Universit� degli Studi di Trento. Dipartimento di Lettere e Filosofia
Year: 2017

description: Il testo esplora il sentimento latino della pietas, inteso come rispetto e perdono nei confronti dei vinti. Sovente associata con aspetti della religiosit�, la pietas ricorre frequentemente nella letteratura occidentale di ogni tempo, ma � pi� rara nel teatro, vuoi per cultura, vuoi per l?intrinseca struttura drammaturgica del testo teatrale, basato sul conflitto. In questo scritto si intende dimostrare come in alcuni testi teatrali la pietas rafforzi il denouement drammaturgico, senza nulla togliere al conflitto e al dualismo tra protagonista e antagonista.
Diplomatici in azione. Aspetti giuridici e politici della prassi diplomatica nel mondo contemporaneo. Volume II
Creators: name: Nesi, Giuseppe
name: Baldi, S.
Publisher: name: Universit� degli Studi di Trento
Year: 2016

description: Il secondo volume di ?Diplomatici in azione? si pone nel solco tracciato dal primo, pubblicato nel 2015, e prende spunto da un?originale esperienza didattica condotta in videoconferenza tra il Ministero degli Affari Esteri a Roma e l?Universit� di Trento a partire dall?anno accademico 2013-14. Gli interventi contenuti in questo volume sono infatti il frutto della seconda edizione del laboratorio applicativo su ?La diplomazia contemporanea tra diritto e prassi?, tenutosi durante l?anno accademico 2014-2015, con interventi di diplomatici che hanno presentato agli studenti della Facolt� di Giurisprudenza i tratti essenziali di alcune delle loro esperienze ?sul campo?. Come avvenuto per il precedente volume, l?idea � quella di descrivere specifiche attivit� operative svolte dalla diplomazia italiana attraverso il contributo di coloro sui quali ricadono in prima persona le responsabilit� connesse a quelle attivit�. In particolare, gli studenti hanno avuto la possibilit� di conoscere direttamente da chi li pratica gli strumenti, le azioni concrete e le limitazioni oggettive che caratterizzano la diplomazia contemporanea. Si tratta di esperienze di diverso impatto che, insieme a quanto appreso sulla base dei programmi dei corsi universitari, permetteranno agli studenti di capire meglio, tra l?altro, le attivit� svolte dalla nostra diplomazia e il ruolo del Ministero degli Esteri nell'ambito della politica internazionale. Gli studenti hanno accolto con entusiasmo e interesse l?iniziativa e anche i diplomatici hanno partecipato con impegno e spirito costruttivo, sicch� il laboratorio applicativo ha avuto molto successo. I temi affrontati in questo secondo volume sono numerosi e spaziano da quelli pi� generici, come il funzionamento di un?Ambasciata o il ruolo del Ministero degli Affari Esteri nella politica europea dell?Italia, a quelli pi� specifici ma non per questo secondari, come ad esempio il funzionamento del sistema delle borse di studio e degli scambi giovanili o il ruolo dell?ufficio rapporti con il Parlamento.
Tris-borate is a poor counterion for RNA: a cautionary tale for RNA folding studies
Creators: name: Buchmueller, Karen L.
name: Weeks, Kevin M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Native polyacrylamide gel electrophoresis is a powerful approach for visualizing RNA folding states and folding intermediates. Tris-borate has a high-buffering capacity and is therefore widely used in electrophoresis-based investigations of RNA structure and folding. However, the effectiveness of Tris-borate as a counterion for RNA has not been systematically investigated. In a recirculated Hepes/KCl buffer, the catalytic core of the bI5 group I intron RNA undergoes a conformational collapse characterized by a bulk transition midpoint, or Mg1/2, of ∼3 mM, consistent with extensive independent biochemical experiments. In contrast, in Tris-borate, RNA collapse has a much smaller apparent Mg1/2, equal to 0.1 mM, because in this buffer the RNA undergoes a different, large amplitude, folding transition at low Mg2+ concentrations. Analysis of structural neighbors using a short-lived, RNA-tethered, photocrosslinker indicates that the global RNA structure eventually converges in the two buffer systems, as the divalent ion concentration approaches ∼1 mM Mg2+. The weak capacity of Tris-borate to stabilize RNA folding may reflect relatively unfavorable interactions between the bulky Tris-borate ion and RNA or partial coordination of RNA functional groups by borate. Under some conditions, Tris-borate is a poor counterion for RNA and its use merits careful evaluation in RNA folding studies.
Supplementary Information from Pathogen shifts in a honeybee predator following the arrival of the Varroa mite
Creators: name: Loope, Kevin J.
name: Baty, James W.
name: Lester, Philip J.
name: Rankin, Erin E. Wilson
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: This file contains additional methods details, as well as the supplementary figures and tables.
Additional file 5 of Cardiac reverse remodeling in primary mitral regurgitation: mitral valve replacement vs. mitral valve repair
Creators: name: Craven, Thomas P.
name: Chew, Pei G.
name: Dobson, Laura E.
name: Gorecka, Miroslawa
name: Parent, Martine
name: Brown, Louise A. E.
name: Saunderson, Christopher E. D.
name: Das, Arka
name: Chowdhary, Amrit
name: Jex, Nicholas
name: Higgins, David M.
name: Dall’Armellina, Erica
name: Levelt, Eylem
name: Schlosshan, Dominik
name: Swoboda, Peter P.
name: Plein, Sven
name: Greenwood, John P.
Publisher: name: figshare
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology

description: Additional file 5. Subgroup analysis of surgical groups by baseline presence or absence of late gadolinium enhanced myocardium. Subgroup analysis of surgical groups comparing those with and without late gadolinium enhancement at baseline—baseline patient characteristics and surgical parameters (Table S8) and baseline, change and follow-up CMR and functional parameters (Table S9).
A proof of two conjectures of Chao-Ping Chen for inverse trigonometric functions
Creators: name: Malesevic, Branko
name: Banjac, Bojan
name: Jovovic, Ivana
Publisher: name: arXiv
Year: 2015
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics
subject: 26D05

description: In this paper we prove two conjectures stated by Chao-Ping Chen in [Int. Trans. Spec. Funct. 23:12 (2012), 865--873], using a method for proving inequalities of mixed trigonometric polynomial functions.
Improvement of Control System Performance by Modification of Time Delay
Creators: name: Alkhalaf, Salem
Publisher: name: arXiv
Year: 2015
Subjects: subject: Systems and Control (eess.SY)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: This paper presents a mathematical approach for improving the performance of a control system by modifying the time delay at certain operating conditions. This approach converts a continuous time loop into a discrete time loop. The formula derived is applied successfully to an applicable control system. The results show that the proposed approach efficiently improves the control system performance. The relation between the sampling time and the time delay is obtained. Two different operating conditions are examined to assess the proposed approach in improving the performance of the control system.
description: 5
L?elemento normativo nella fattispecie penale. Questioni sistematiche e costituzionali
Creators: name: Bonini, Sergio
Publisher: name: Universit� degli Studi di Trento
Year: 2016

description: Il libro mette al centro la figura dell?elemento normativo, studiandone la species dell?elemento tecnicamente specificato; rileggendo pagine classiche e pagine meno note su concetti descrittivi e concetti normativi (con relativi ?negazionismi?); motivandone la separabilit� dal ?descrittivo?; argomentandone l?inserimento non nell?antigiuridicit� ma nel fatto; discutendone il rapporto con il principio di determinatezza.