cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
BindingDB Entry 50019187: Mechanistic Insight of Synthesized 1,4-Dihydropyridines as an Antidiabetic Sword against Reactive Oxygen Species.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Dipeptidyl peptidase 4, Platelet-derived growth factor receptor alpha/beta, Probable maltase-glucoamylase 2, and Sodium/glucose cotransporter 2, Tanta University, Affinity

description: Small molecule binding data for protein Dipeptidyl peptidase 4, Platelet-derived growth factor receptor alpha/beta, Probable maltase-glucoamylase 2, and Sodium/glucose cotransporter 2, Uniprot P05622, P26618, P27487, P31639, and Q2M2H8
Myrmicaria eumenoides subsp. opaciventris var. crucheti
Creators: name: Wheeler, W. M.
Publisher: name: Zenodo
Year: 1922
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Myrmicaria
Myrmicaria eumenoides
Myrmicaria eumenoides subspecies opaciventris variety crucheti (santschi)

description: Myrmicaria eumenoides subspecies opaciventris variety crucheti (Santschi)
Stanleyville, [[worker]]; Leopoldville, [[worker]]; Ngayu, [[worker]]; Avakubi, [[worker]] (Lang and Chapin). The workers from Avakubi, 22 in number, were taken from the stomachs of toads (Bufo regularis and B. funereus). I refer numerous specimens from these localities to the variety crucheti since they agree with Santschi's very brief description in size (5 to 5.5 mm.) and in having slender but straight epinotal spines. The petiolar node in my specimens is distinctly broader and less compressed laterally than in the typical eumenoides and not shorter than the peduncle. The surface of the petiole is not so smooth, though it is not longitudinally rugulose. I have received this same form in all three phases from Rev. Geo. Schwab, who took it at Metit, Cameroon. The female is very similar to that of the typical eumenoides, but the head is somewhat smaller, with slightly more prominent posterior corners and the gaster is entirely opaque and punctate, except the bases of the second and following segments. I am unable to detect any differences between the males of the two forms. Arnold describes the wings of the male eumenoides as paler than those of the female. This is certainly not the case in crucheti.
description: Published as part of Wheeler, W. M., 1922, The ants collected by the American Museum Congo Expedition., pp. 39-269 in Bulletin of the American Museum of Natural History 45 on page 146
Mesonemoura aberransterga Du & Zhou, sp. nov.
Creators: name: Du, Yu-Zhou
name: Wang, Zhi-Jie
name: Zhou, Pei
Publisher: name: Zenodo
Year: 2007
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Plecoptera
Nemouridae
Mesonemoura
Mesonemoura aberransterga

description: Mesonemoura aberransterga Du & Zhou, sp. nov.
(Fig. 1–8)
Adult habitus. Head and pronotum dark brown and equal in width to pronotum; wings subhyaline, brown, veins dark brown. Cervical gills single, short and oval, each one is located outside of lateral cervical sclerite.
4 6 7 8 Male. Forewing length 6.8–8.3 mm, hindwing length 5.6–6.8 mm. Tergum 9 sclerotized and bizarre in shape, middle of posterior and anterior margin extending acutely toward tergum 8, even inserting past posterior margin of tergum 8. Tergum 10 sclerotized, forming a large concave area anterior to base of epiproct, bearing a few hairs anteriomedially; margin of the tergum also extending acutely into tergum 9, reaching to its posterior margin. Cercus longer than wide. Hypoproct broad at base, tapering to a narrow apex, covering part of inner lobes of paraprocts. Paraprocts divided into 3 lobes; inner lobe triangular, slightly sclerotized, and branched at apex; median lobe partially sclerotized, forming a long sclerotized bar without spines, membranous portions broad at base; outer lobe mostly sclerotized, without spines or hairs. Epiproct short and thin; dorsal sclerite narrow; lateral arms darkly sclerotized; ventral sclerite darkly sclerotized, becoming narrower toward apex, bearing a few stout denticles, the apex extended distally, forming a flagelliform sclerotized structure reaching to posterior margin of tergum 8, length of the projection is about two times the length of the epiproct.
Female. Forewing length 8.5–9.0 mm, hindwing length 7.5–8.0 mm. Sternum 8 produced posteriorly, forming two long and flat lobes extending across half of sternum 9, produced area lightly sclerotized; sternum 9 produced posteriorly into lightly sclerotized dome bearing a few hairs on it.
Type material. Holotype male, from Daocheng county to Xiangcheng county (the 149th highway maintenance squad where is 50 km north away from Xiangcheng county), Sichuan province, 4060 m, 12 June 1996, Leg. Du Yu-Zhou. Paratypes 4 m and 4 f, same data as the holotype.
Etymology. The name refers to the bizarre shape of terga 9 & 10, the Latin aberrans meaning to go astray or wander.
Remarks. This new species is similar to Mesonemoura spiroflagellata (Wu) in the shape of epiproct, but distinctly differ in the bizarre shape of terga 9 & 10.
description: Published as part of Du, Yu-Zhou, Wang, Zhi-Jie & Zhou, Pei, 2007, Two new species of the genus Mesonemoura and redescription of M. spiroglagellate (Plecoptera: Nemouridae) from China, pp. 47-52 in Zootaxa 1495 on pages 47-49, DOI: 10.5281/zenodo.177035
BindingDB Entry 50019186: Indole Derivatives as New Structural Class of Potent and Antiproliferative Inhibitors of Monocarboxylate Transporter 1 (MCT1; SLC16A1).
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: ATP-dependent translocase ABCB1, Monocarboxylate transporter 1, and Multidrug resistance-associated protein 1, Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, Affinity

description: Small molecule binding data for protein ATP-dependent translocase ABCB1, Monocarboxylate transporter 1, and Multidrug resistance-associated protein 1, Uniprot P08183, P33527, and P53985
MOESM1 of Cell foundry with high product specificity and catalytic activity for 21-deoxycortisol biotransformation
Creators: name: Shuting Xiong
name: Wang, Ying
name: Mingdong Yao
name: Liu, Hong
name: Zhou, Xiao
name: Wenhai Xiao
name: Yingjin Yuan
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 1: Table S1. Oligonucleotides used in this study. Table S2. Plasmids used in this study. Table S3. The Codon-optimized sequences of CY11B1, Adx and AdR involved in this study. Figure S1. Schematic representation of the constructing strategies for Adx 4–108 -CYP11B1-AdR co-expression plasmid (pETXST39–56). Figure S2. Schematic representation of the mutagenesis strategy applied in this study. Figure S3. Alignment of CYP11B1 s from nine species screened in this study. Figure S4. Conversion of 17-OHP to 21-DF by biocatalysts harboring different wild-type and mutated CYP11B1s from diversity species. Figure S5. Optimizing substrate concentration for higher biocatalyst efficiency. Figure S6. Biotransformation of 17-OHP to 21-DF by strains Ec02040126 and Ec02040110 during the time course.
Leptotrombidium (Leptotrombidium) pentafurcatum Wen and Xiang 1984
Creators: name: Nielsen, David H.
name: Robbins, Richard G.
name: Rueda, Leopoldo M.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Actinedida
Trombiculidae
Leptotrombidium
Leptotrombidium pentafurcatum

description: Leptotrombidium (Leptotrombidium) pentafurcatum Wen and Xiang, 1984c:
PAL
Leptotrombidium pentafurcatum, Stekolnikov 2013 [deliense group]
description: Published as part of Nielsen, David H., Robbins, Richard G. & Rueda, Leopoldo M., 2021, Annotated world checklist of the Trombiculidae and Leeuwenhoekiidae (1758 - 2021) (Acari: Trombiculoidea), with notes on nomenclature, taxonomy, and distribution, pp. 1-243 in Zootaxa 4967 (1) on page 137, DOI: 10.11646/zootaxa.4967.1.1, http://zenodo.org/record/4745510
MOESM1 of Frequency, associated factors and outcome of multi-drug-resistant intensive care unit-acquired pneumonia among patients colonized with extended-spectrum Î˛-lactamase-producing Enterobacteriaceae
Creators: name: Razazi, Keyvan
name: Dessap, Armand Mekontso
name: Carteaux, Guillaume
name: ChloĂŠ Jansen
name: Jean-Winoc Decousser
name: Prost, Nicolas De
name: Brun-Buisson, Christian
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. . Additional results (Tables S1 to S6).
BindingDB Entry 50019184: Structure-Based Design of the Indole-Substituted Triazolopyrimidines as New EED-H3K27me3 Inhibitors for the Treatment of Lymphoma.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Polycomb protein EED, Zhengzhou University, Affinity

description: Small molecule binding data for protein Polycomb protein EED, Uniprot O75530
Mesonemoura membranosa Du & Zhou, sp. nov.
Creators: name: Du, Yu-Zhou
name: Wang, Zhi-Jie
name: Zhou, Pei
Publisher: name: Zenodo
Year: 2007
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Plecoptera
Nemouridae
Mesonemoura
Mesonemoura membranosa

description: Mesonemoura membranosa Du & Zhou, sp. nov.
(Fig. 9–15)
Adult habitus. Head equal in width to pronotum; wings subhyaline to brown. Cervical gills single, short and oval, each one is located outside of lateral cervical sclerite. Metathoracic femora with distinct pattern, distally dark, with rest of the legs pale.
Male. Forewing length 9.6 mm, hind wing length 8.5 mm. Tergum 9 slightly sclerotized, posteromesal margin concave, forming a small notch, both sides of notch slightly protruding past the posterior edge of tergum, each with sclerotized spines around the apex. Tergum 10 slightly sclerotized, forming a large flat area anterior to base of epiproct. Cercus longer than wide. Hypoproct broad at base, tapering towards apex, covering part of inner lobes of paraprocts; vesicle long, 3X width. Paraprocts divided into 3 mostly membranous lobes; inner lobe small, triangular, slightly sclerotized; median lobe large and broad at base with a small apical portion, bearing many hairs; outer lobe narrow and slightly sclerotized at base, broad and membranous apically, bearing many hairs. Epiproct dorsally a narrow rectangle, recurved; dorsal sclerite, milky-white with little brownish markings, apical portion slightly enlarged and extending over ventral sclerite; ventral sclerite darkly sclerotized, broad at base and becoming narrower toward apex, the apex extended distally to forming a long flagelliform, sclerotized structure; the flagelliform projection inserted into notch of tergum 9, with a single spiral, its length is about 2X length of the epiproct, and with a little notch at the tip; epiproct ventral sclerite without spines.
Female. Unknown.
Type material. Holotype male, Railway Station of Qinling, Shaanxi province, 17 May 1995, Leg. Du Yu- Zhou. Paratype male, same data as the holotype.
Etymology. The name refers to the paraprocts being mostly membranous. The Latin membrana means membranous.
Remarks. This new species is close to Mesonemoura metafiligera (Aubert 1965) in the shape of epiproct and paraproct, but distinctly differ in the strongly sclerotized spines located on the margin of the notch of tergum 9, and the little notch at the tip of the flagelliform peojection.
11 12
description: Published as part of Du, Yu-Zhou, Wang, Zhi-Jie & Zhou, Pei, 2007, Two new species of the genus Mesonemoura and redescription of M. spiroglagellate (Plecoptera: Nemouridae) from China, pp. 47-52 in Zootaxa 1495 on pages 49-50, DOI: 10.5281/zenodo.177035
BindingDB Entry 50019183: Novel Small-Molecule PD-L1 Inhibitor Induces PD-L1 Internalization and Optimizes the Immune Microenvironment.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Platelet-derived growth factor receptor alpha/beta and Programmed cell death 1 ligand 1, China Pharmaceutical University, Affinity

description: Small molecule binding data for protein Platelet-derived growth factor receptor alpha/beta and Programmed cell death 1 ligand 1, Uniprot P05622, P26618, and Q9NZQ7
BindingDB Entry 50019182: Physachenolide C is a Potent, Selective BET Inhibitor.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Bromodomain testis-specific protein, Bromodomain-containing protein 2, Bromodomain-containing protein 3, and Bromodomain-containing protein 4, University of Arizona, Affinity

description: Small molecule binding data for protein Bromodomain testis-specific protein, Bromodomain-containing protein 2, Bromodomain-containing protein 3, and Bromodomain-containing protein 4, Uniprot O60885, P25440, Q15059, and Q58F21
BindingDB Entry 50019180: Discovery of the Potent and Highly Selective PARP7 Inhibitor as a Novel Immunotherapeutic Agent for Tumors.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Poly [ADP-ribose] polymerase 1, Poly [ADP-ribose] polymerase 2, Poly [ADP-ribose] polymerase tankyrase-1, Poly [ADP-ribose] polymerase tankyrase-2, Protein mono-ADP-ribosyltransferase PARP10, Protein mono-ADP-ribosyltransferase PARP11, Protein mono-ADP-ribosyltransferase PARP12, Protein mono-ADP-ribosyltransferase PARP14, and Protein mono-ADP-ribosyltransferase TIPARP, China Pharmaceutical University, Affinity

description: Small molecule binding data for protein Poly [ADP-ribose] polymerase 1, Poly [ADP-ribose] polymerase 2, Poly [ADP-ribose] polymerase tankyrase-1, Poly [ADP-ribose] polymerase tankyrase-2, Protein mono-ADP-ribosyltransferase PARP10, Protein mono-ADP-ribosyltransferase PARP11, Protein mono-ADP-ribosyltransferase PARP12, Protein mono-ADP-ribosyltransferase PARP14, and Protein mono-ADP-ribosyltransferase TIPARP, Uniprot O95271, P09874, Q460N5, Q53GL7, Q7Z3E1, Q9H0J9, Q9H2K2, Q9NR21, and Q9UGN5
MOESM1 of Frequency, associated factors and outcome of multi-drug-resistant intensive care unit-acquired pneumonia among patients colonized with extended-spectrum Î˛-lactamase-producing Enterobacteriaceae
Creators: name: Razazi, Keyvan
name: Dessap, Armand Mekontso
name: Carteaux, Guillaume
name: ChloĂŠ Jansen
name: Jean-Winoc Decousser
name: Prost, Nicolas De
name: Brun-Buisson, Christian
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. . Additional results (Tables S1 to S6).
BindingDB Entry 50019179: Targeted Protein Degradation Induced by HEMTACs Based on HSP90.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Heat shock protein HSP 90-alpha, Shandong University, Affinity

description: Small molecule binding data for protein Heat shock protein HSP 90-alpha, Uniprot P07900
Cardiocondyla
Creators: name: Wheeler, W. M.
Publisher: name: Zenodo
Year: 1922
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Cardiocondyla

description: Cardiocondyla Emery
Worker minute, smooth, almost hairless. Clypeus projecting over the bases of the mandibles, steep in front, with rounded anterior border. Frontal area strongly impressed. Frontal carinae short and straight. Eyes well developed; ocelli lacking. Mandibles broad, triangular, dentate. Antennae 12-jointed, with long first funicular joint and 3-jointed club, the last joint very large. Promesonotal suture indistinct; mesoepinotal constriction well developed. Epinotum armed with spines or teeth. Petiole with long peduncle and small, rounded node. Postpetiole conspicuously large, cordate or transversely elliptical. Gaster formed in large part by the first segment.
Female winged (except in C. emeryi Forel), somewhat larger than the worker; head of the same shape but with ocelli. Pronotum not covered by the mesoscutum in front. Petiole and postpetiole usually broader than in the worker. Wings with reduced venation; pterostigma near the middle of the costal border; one closed cubital cell; distal portions of radius and cubitus obsolete; brachius not developed beyond the nervulus but bending up into the submedius. According to Emery, the female of C. emeryi is wingless and has the posterior ocelli vestigial.
Male usually ergatomorphic but winged in C. emeryi. In this form the antennae are 13-jointed but in ergatomorphic males they are 10- to 12-jointed; with long scape and more indistinct club. Petiole and postpetiole resembling the corresponding segments of the female, in the male of emeryi much as in the worker.
description: Published as part of Wheeler, W. M., 1922, The ants collected by the American Museum Congo Expedition., pp. 39-269 in Bulletin of the American Museum of Natural History 45 on page 149
Additional file 1: of Perceptions of measles, pneumonia, and meningitis vaccines among caregivers in Shanghai, China, and the health belief model: a cross-sectional study
Creators: name: Wagner, Abram
name: Boulton, Matthew
name: Xiaodong Sun
name: Bhramar Mukherjee
name: Zhuoying Huang
name: Harmsen, Irene
name: Ren, Jia
name: Zikmund-Fisher, Brian
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: English version of questionnaire, April 3, 2014. (PDF 242 kb)
BindingDB Entry 50019178: Synthetic Strategies for Improving Solubility: Optimization of Novel Pyrazolo[1,5-
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Cystic fibrosis transmembrane conductance regulator, Yonsei University, Affinity

description: Small molecule binding data for protein Cystic fibrosis transmembrane conductance regulator, Uniprot P13569
Additional file 1: of Microglia limit the expansion of β-amyloid plaques in a mouse model of Alzheimer’s disease
Creators: name: Ruohe Zhao
name: Wanling Hu
name: Tsai, Julia
name: Li, Wei
name: Gan, Wen-Biao
Publisher: name: Figshare
Year: 2017
Subjects: subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 60506 Virology

description: Microglia are depleted in APP/PS1/CX 3 CR1-iDTR mice over 1–7 days after DT administration and repopulate within 2 weeks after DT administration. a. Timeline of tamoxifen administration, DT administration and two-photon (2P) imaging. Microglia were examined before (D9), 1 day after (D13), 1 week after (D20) and 2 weeks after DT administration (D27). b. Time-lapse imaging in the same region in APP/PS1/CX 3 CR1-iDTR mice and microglia morphology is revealed by CreER-IRES-EYFP under CX 3 CR1 promoter. The effects of DT administration over 1–2 weeks are similar to the effects on CX 3 CR1-iDTR mice (Fig. 1b). (PDF 1380 kb)
Crematogaster brunneipennis subsp. acaciae var. victoriosa
Creators: name: Wheeler, W. M.
Publisher: name: Zenodo
Year: 1922
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Crematogaster
Crematogaster brunneipennis
Crematogaster brunneipennis (ern. andre) subspecies acaciae (forel) variety victoriosa (santschi)

description: Crematogaster brunneipennis (Ern. André) subspecies acaciae (Forel) variety victoriosa (Santschi)
Numerous workers from Zambi (Bequaert), "nesting in a tree trunk." The typical C. acaciae was originally taken by Keller in Somaliland in the swollen spines of acacias. Concerning one of the other varieties (generosa Santschi), Santschi writes me as follows: "I received from Mr. G. Arnold of the Rhodesian Museum under the name of C. brunneipennis Ern. André variety omniparens Forel some workers which differ only in their deeper color from what I have called acaciae variety generosa. The female of the latter form is very close to that of brunneipennis Ern. Andr 6, but the wings are even darker. I believe that brunneipennis should be regarded as a subspecies of C. acaciae." That Santschi is correct in regarding both forms as cospecific is proved by a comparison of two cotype workers of brunneipennis from Sierra Leone (Mocquerys), sent me by André many years ago, with a cotype of received from Forel. André workers are smaller, with longer antennal scapes, smoother and more polished thorax, with somewhat more circular and less cordate petiole, smaller and more slender and more pointed epinotal spines, and darker gaster and head, but the resemblances are so close in other respects that I cannot regard the differences as more than subspecific. As brunneipennis has priority of publication, acaciae must be reduced in rank and not brunneipennis, as Santschi supposes. Whether omniparens is to be retained as a distinct subspecies or is to be attached as a variety to acaciae, I am unable to determine.
description: Published as part of Wheeler, W. M., 1922, The ants collected by the American Museum Congo Expedition., pp. 39-269 in Bulletin of the American Museum of Natural History 45 on page 152
BindingDB Entry 50019177: Discovery of DS-9300: A Highly Potent, Selective, and Once-Daily Oral EP300/CBP Histone Acetyltransferase Inhibitor.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: CREB-binding protein, Histone acetyltransferase KAT2A, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase KAT6B, Histone acetyltransferase KAT7, and Histone acetyltransferase p300, Daiichi Sankyo Co., Affinity

description: Small molecule binding data for protein CREB-binding protein, Histone acetyltransferase KAT2A, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase KAT6B, Histone acetyltransferase KAT7, and Histone acetyltransferase p300, Uniprot O95251, Q09472, Q8WYB5, Q92793, Q92830, Q92831, and Q92993
BindingDB Entry 50019176: Inhibition of the Ubiquitin Transfer Cascade by a Peptidomimetic Foldamer Mimicking the E2 N-Terminal Helix.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Ubiquitin-like modifier-activating enzyme 1, Georgia State University, Affinity

description: Small molecule binding data for protein Ubiquitin-like modifier-activating enzyme 1, Uniprot P22314
Additional file 1: of Microglia limit the expansion of β-amyloid plaques in a mouse model of Alzheimer’s disease
Creators: name: Ruohe Zhao
name: Wanling Hu
name: Tsai, Julia
name: Li, Wei
name: Gan, Wen-Biao
Publisher: name: Figshare
Year: 2017
Subjects: subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Virology

description: Microglia are depleted in APP/PS1/CX 3 CR1-iDTR mice over 1–7 days after DT administration and repopulate within 2 weeks after DT administration. a. Timeline of tamoxifen administration, DT administration and two-photon (2P) imaging. Microglia were examined before (D9), 1 day after (D13), 1 week after (D20) and 2 weeks after DT administration (D27). b. Time-lapse imaging in the same region in APP/PS1/CX 3 CR1-iDTR mice and microglia morphology is revealed by CreER-IRES-EYFP under CX 3 CR1 promoter. The effects of DT administration over 1–2 weeks are similar to the effects on CX 3 CR1-iDTR mice (Fig. 1b). (PDF 1380 kb)
Leptotrombidium (Leptotrombidium) pentagonum Yang, Zheng and Li 1996
Creators: name: Nielsen, David H.
name: Robbins, Richard G.
name: Rueda, Leopoldo M.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Actinedida
Trombiculidae
Leptotrombidium
Leptotrombidium pentagonum

description: Leptotrombidium (Leptotrombidium) pentagonum Yang, Zheng and Li, 1996:
PAL
Leptotrombidium pentagonum Yang, Zheng and Li, 1996; Stekolnikov 2013 [pentagonum group]
description: Published as part of Nielsen, David H., Robbins, Richard G. & Rueda, Leopoldo M., 2021, Annotated world checklist of the Trombiculidae and Leeuwenhoekiidae (1758 - 2021) (Acari: Trombiculoidea), with notes on nomenclature, taxonomy, and distribution, pp. 1-243 in Zootaxa 4967 (1) on pages 137-138, DOI: 10.11646/zootaxa.4967.1.1, http://zenodo.org/record/4745510
Zodarion Walckenaer 1826
Creators: name: Coşar, İlhan
name: Danişman, Tarik
name: Elverici, Mert
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Zodariidae
Zodarion

description: Zodarion Walckenaer, 1826
Type species. Enyo nitida Audouin, 1826
Comments. With 176 extant species, Zodarion is the largest genus within Zodariinae (WSC, 2022). Based on the diverse conformations in the copulatory organs of the species currently noted in this genus, Zodarion does not appear to be monophyletic (Zamani & Marusik, 2021). Only Z. luctuosum (O. Pickard-Cambridge, 1872) and Z. lutipes (O. Pickard-Cambridge, 1872) from the Eastern Mediterranean are morphologically similar to the generotype (Zamani & Marusik, 2021). 30 Zodarion species have been recorded so far in Turkey, although this number is slightly less than Greece (35) but higher than Azerbaijan (7), Bulgaria (14), Cyprus (5), Iran (4), and Israel (Nentwig et al 2022; Otto 2022; Zamani & Marusik 2022; Zamani et al. 2022; Zonstein & Marusik 2013).
description: Published as part of Coşar, İlhan, Danişman, Tarik & Elverici, Mert, 2022, First description of the females of two species of Zodarion (Araneae: Zodariidae), pp. 92-100 in Zootaxa 5178 (1) on page 93, DOI: 10.11646/zootaxa.5178.1.6, http://zenodo.org/record/7022123
Myrmicaria salambo Wheeler, 1922, new species
Creators: name: Wheeler, W. M.
Publisher: name: Zenodo
Year: 1922
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Myrmicaria
Myrmicaria salambo

description: Myrmicaria salambo, new species
Plate IX, Figures 1 and 2; Text Figure 37
Worker.- Length 6 to 7 mm.
Of rather uniform stature and closely resembling eumenoides but a little more elongate. Head relatively smaller, as broad as long, excavated behind, convex above, flattened below. Mandibles 5-toothed. Clypeus ccarinate, with entire anterior border. Eyes somewhat larger and more convex than in eumenoides. Thorax very similar but premesonotal suture very distinct, impressed, the mesonotal lobes less compressed, their posterior outline in profile less abrupt, more sloping so that the mesoepinotal impression, though deep, is shallower and less acute than in eumenoides and appears longer. Epinotal spines longer, slightly sinuous, with very feebly upturned points, directed backward and slightly outward. Base of epinotum longitudinally concave. Peduncle of the petiole longer than the node, which is thick and evenly rounded, not compressed laterally above. The ventral surface of the petiole armed below with two long, delicate hyaline spines, which curve towards each other and enclose an elliptical space. Postpetiolar node of the same size and shape as that of the petiole, its ventral surface straight in profile, not bulging nor angulate in front. Gaster and legs of the usual shape, the former with a straight, anterior border.
Shining; mandibles coarsely longitudinally striated; clypeus smooth in the middle, with a few rugules on the sides. Rugosity of head, thorax, and pedicel much as in eumenoides, but the rugae on the dorsal surface of the head and thorax less numerous and less pronounced, without distinct anastomoses; sides of the head with finer and less distinct rugules, so that the surface is more shining. Gaster opaque and very finely punctate only at the extreme base above, otherwise shining. Legs and scapes shining, finely striate.
Hairs dark brown, in length and arrangement much like those of eumenoides.
Reddish brown; gaster brownish yellow; legs, including the coxae and lower pleurae, darker than the thorax. Mandibular teeth and antennae blackish.
Described from numerous specimens taken at Garamba (Lang and Chapin) attending scale insects on the buds of a Protea which is shown in Plate IX.
This form is so closely related to eumenoides that it might, perhaps, be regarded as a subspecies. It is easily recognized by the unique ventral appendages of the petiole. These are so brittle that they are easily broken off, but their basal insertions on the low hyaline lamella in the midventral line of the petiole are usually discernible. Evidently salambo is also related to M. striata Stitz, specimens of which I have not seen.
description: Published as part of Wheeler, W. M., 1922, The ants collected by the American Museum Congo Expedition., pp. 39-269 in Bulletin of the American Museum of Natural History 45 on pages 147-148
Additional file 4: of Analysis and prediction of single-stranded and double-stranded DNA binding proteins based on protein sequences
Creators: name: Wang, Wei
name: Sun, Lin
name: Shiguang Zhang
name: Hongjun Zhang
name: Jinling Shi
name: Tianhe Xu
name: Keliang Li
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: This file contains the results of leave-one-out cross validation. (DOCX 24Â kb)
Additional file 1: Table S1. of LASP2 suppresses colorectal cancer progression through JNK/p38 MAPK pathway meditated epithelial-mesenchymal transition
Creators: name: Wang, Bin
name: Lanzhi Zhang
name: Liying Zhao
name: Zhou, Rui
name: Yanqing Ding
name: Guoxin Li
name: Zhao, Liang
Publisher: name: Figshare
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer

description: Relationship between LASP2 expression and the clinicopathological features of CRC patients. Table S2. Univariate and multivariate analyses of individual parameters for correlations with overall survival rate: Cox proportional hazards model. (DOCX 21Â kb)
MPEC 2025-A176 : 2025 AC4
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2025
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2025 AC4

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
BindingDB Entry 50019175: Discovery of Highly Potent Nicotinamide Phosphoribosyltransferase Degraders for Efficient Treatment of Ovarian Cancer.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Nicotinamide phosphoribosyltransferase, Second Military Medical University, Affinity

description: Small molecule binding data for protein Nicotinamide phosphoribosyltransferase, Uniprot P43490
BindingDB Entry 50019174: Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Potassium voltage-gated channel subfamily H member 2, Protein AF-9, Protein ENL, YEATS domain-containing protein 2, and YEATS domain-containing protein 4, Pfizer, Affinity

description: Small molecule binding data for protein Potassium voltage-gated channel subfamily H member 2, Protein AF-9, Protein ENL, YEATS domain-containing protein 2, and YEATS domain-containing protein 4, Uniprot O95619, P42568, Q03111, Q12809, and Q9ULM3
BindingDB Entry 50019173: Small-Molecule Cyanamide Pan-TEAD·YAP1 Covalent Antagonists.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Transcriptional enhancer factor TEF-1, Transcriptional enhancer factor TEF-3, Transcriptional enhancer factor TEF-4, and Transcriptional enhancer factor TEF-5, Indiana University, Affinity

description: Small molecule binding data for protein Transcriptional enhancer factor TEF-1, Transcriptional enhancer factor TEF-3, Transcriptional enhancer factor TEF-4, and Transcriptional enhancer factor TEF-5, Uniprot P28347, Q15561, Q15562, and Q99594
Cardiocondyla emeryi
Creators: name: Wheeler, W. M.
Publisher: name: Zenodo
Year: 1922
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Cardiocondyla
Cardiocondyla emeryi

description: Cardiocondyla emeryi Forel
A single worker taken at Thysville by Bequaert. This minute ant is very widely distributed through the tropics of both hemispheres. It was originally described from the island of St. Thomas in the West Indies, but was later recorded from Syria, Madeira, Madagascar, and the East Indies. Arnold records it from South Africa and my collection contains specimens from the Bahamas, Cuba, Porto Rico, Jamaica, Bermuda, Tepic in Western Mexico, and Miami, Florida. According to Arnold it "is usually found nesting in grassy soil; the entrance to the nest is a minute hole, not surrounded by earth or other substances."
description: Published as part of Wheeler, W. M., 1922, The ants collected by the American Museum Congo Expedition., pp. 39-269 in Bulletin of the American Museum of Natural History 45 on page 150
BindingDB Entry 50019172: Development of
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Cannabinoid receptor 1, Cannabinoid receptor 2, and Fatty-acid amide hydrolase 1, University Degli Studi Di Bari Aldo Moro, Affinity

description: Small molecule binding data for protein Cannabinoid receptor 1, Cannabinoid receptor 2, and Fatty-acid amide hydrolase 1, Uniprot O00519, P21554, P34972, and P47936
Additional file 1: of Sliding Speed-Dependent Tribochemical Wear of Oxide-Free Silicon
Creators: name: Chen, Lei
name: Yaqiong Qi
name: Bingjun Yu
name: Linmao Qian
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biophysics
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Supporting information. Figure S1. SEM and AFM images of SiO2 microspherical tip. Figure S2. Three-dimensional morphologies and their corresponding cross-section profiles of Si wear formed in dry air (a) and in humid air (b). Figure S3. AFM images and profiles of SiO2 microspheres used in nanowear tests. (a) before nanowear tests; (b) schematic of tip-scanning-tip method; (c) after 100 sliding cycles in humid air; (d) after 5000 sliding cycles in humid air; and (e) after 5000 sliding cycles in DI water. Profiles of SiO2 microsphere before and after nanowear tests are indicated by thin black lines and thick red lines, respectively. (PDF 1.24 mb)
BindingDB Entry 50019171: Discovery of Macrocycle-Based HPK1 Inhibitors for T-Cell-Based Immunotherapy.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Cytochrome P450 3A4, Dual specificity protein kinase CLK2, High affinity nerve growth factor receptor, Interleukin-1 receptor-associated kinase 4, Misshapen-like kinase 1, Mitogen-activated protein kinase kinase kinase kinase 1, Mitogen-activated protein kinase kinase kinase kinase 2, Mitogen-activated protein kinase kinase kinase kinase 3, Mitogen-activated protein kinase kinase kinase kinase 4, Mitogen-activated protein kinase kinase kinase kinase 5, Potassium voltage-gated channel subfamily H member 2, Serine/threonine-protein kinase TAO1, Tyrosine-protein kinase Mer, and Tyrosine-protein kinase receptor TYRO3, Central China Normal University, Affinity

description: Small molecule binding data for protein Cytochrome P450 3A4, Dual specificity protein kinase CLK2, High affinity nerve growth factor receptor, Interleukin-1 receptor-associated kinase 4, Misshapen-like kinase 1, Mitogen-activated protein kinase kinase kinase kinase 1, Mitogen-activated protein kinase kinase kinase kinase 2, Mitogen-activated protein kinase kinase kinase kinase 3, Mitogen-activated protein kinase kinase kinase kinase 4, Mitogen-activated protein kinase kinase kinase kinase 5, Potassium voltage-gated channel subfamily H member 2, Serine/threonine-protein kinase TAO1, Tyrosine-protein kinase Mer, and Tyrosine-protein kinase receptor TYRO3, Uniprot O95819, P04629, P08684, P49760, Q06418, Q12809, Q12851, Q12866, Q69FE3, Q7L7X3, Q8IVH8, Q8N4C8, Q92918, Q9NWZ3, and Q9Y4K4
Additional file 3: Table S3. of Pooled safety analyses of ALK-TKI inhibitor in ALK-positive NSCLC
Creators: name: Zhu, Qian
name: Hu, Hao
name: Weng, De-Sheng
name: Zhang, Xiao-Fei
name: Chen, Chang-Long
name: Zhou, Zi-Qi
name: Tang, Yan
name: Jian-Chuan Xia
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences

description: Frequency of crizotinib-related AEs gradeÂ â ĽÂ 3 according to the line of treatment (DOC 40 kb)
Additional file 1: of Sliding Speed-Dependent Tribochemical Wear of Oxide-Free Silicon
Creators: name: Chen, Lei
name: Yaqiong Qi
name: Bingjun Yu
name: Linmao Qian
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biophysics
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Supporting information. Figure S1. SEM and AFM images of SiO2 microspherical tip. Figure S2. Three-dimensional morphologies and their corresponding cross-section profiles of Si wear formed in dry air (a) and in humid air (b). Figure S3. AFM images and profiles of SiO2 microspheres used in nanowear tests. (a) before nanowear tests; (b) schematic of tip-scanning-tip method; (c) after 100 sliding cycles in humid air; (d) after 5000 sliding cycles in humid air; and (e) after 5000 sliding cycles in DI water. Profiles of SiO2 microsphere before and after nanowear tests are indicated by thin black lines and thick red lines, respectively. (PDF 1.24 mb)
Crematogaster castanea subsp. inversa var. analis
Creators: name: Wheeler, W. M.
Publisher: name: Zenodo
Year: 1922
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Crematogaster
Crematogaster castanea
Crematogaster castanea f. smith subspecies inversa (forel) variety analis (santschi)

description: Crematogaster castanea F. Smith subspecies inversa (Forel) variety analis (Santschi)
Bafwasende to Avakubi, [[worker]] (Lang and Chapin); Thysville, [[worker]] (J. Bequaert). The specimens from the former locality were collected on the road, without further data; those from Thysville were found "nesting in dry, dead wood, on the soil in the rocky savannah." This and the following are merely color varieties of an extremely variable and widely distributed African and Malagasy species formerly known as C. tricolor Gerstaecker.
description: Published as part of Wheeler, W. M., 1922, The ants collected by the American Museum Congo Expedition., pp. 39-269 in Bulletin of the American Museum of Natural History 45 on page 152
BindingDB Entry 50019170: Chemical Blockage of the Mitochondrial Rhomboid Protease PARL by Novel Ketoamide Inhibitors Reveals Its Role in PINK1/Parkin-Dependent Mitophagy.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Presenilins-associated rhomboid-like protein, mitochondrial and Rhomboid protease GlpG, Institute of Organic Chemistry and Biochemistry of The Czech Academy of Science, Affinity

description: Small molecule binding data for protein Presenilins-associated rhomboid-like protein, mitochondrial and Rhomboid protease GlpG, Uniprot P09391 and Q9H300
BindingDB Entry 50019169: Discovery of Spiro[pyrrolidine-3,3'-oxindole] LXRβ Agonists for the Treatment of Osteoporosis.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta, Sun Yat-Sen University, Affinity

description: Small molecule binding data for protein Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta, Uniprot P55055 and Q13133
Additional file 2: Table S2. of Pooled safety analyses of ALK-TKI inhibitor in ALK-positive NSCLC
Creators: name: Zhu, Qian
name: Hu, Hao
name: Weng, De-Sheng
name: Zhang, Xiao-Fei
name: Chen, Chang-Long
name: Zhou, Zi-Qi
name: Tang, Yan
name: Jian-Chuan Xia
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer

description: Risk of bias in randomized controlled trials (DOC 31 kb)
Additional file 3: Table S3. of Pooled safety analyses of ALK-TKI inhibitor in ALK-positive NSCLC
Creators: name: Zhu, Qian
name: Hu, Hao
name: Weng, De-Sheng
name: Zhang, Xiao-Fei
name: Chen, Chang-Long
name: Zhou, Zi-Qi
name: Tang, Yan
name: Jian-Chuan Xia
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences

description: Frequency of crizotinib-related AEs gradeÂ â ĽÂ 3 according to the line of treatment (DOC 40 kb)
BindingDB Entry 50019168: Discovery of the First Lactate Dehydrogenase Proteolysis Targeting Chimera Degrader for the Treatment of Pancreatic Cancer.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: L-lactate dehydrogenase A chain and L-lactate dehydrogenase B chain, Icahn School of Medicine At Mount Sinai, Affinity

description: Small molecule binding data for protein L-lactate dehydrogenase A chain and L-lactate dehydrogenase B chain, Uniprot P00338 and P07195
Additional file 1: Table S1. of Pooled safety analyses of ALK-TKI inhibitor in ALK-positive NSCLC
Creators: name: Zhu, Qian
name: Hu, Hao
name: Weng, De-Sheng
name: Zhang, Xiao-Fei
name: Chen, Chang-Long
name: Zhou, Zi-Qi
name: Tang, Yan
name: Jian-Chuan Xia
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Cancer

description: Nine-point Newcastle Ottawa scale scores for the non-randomized controlled trials (DOC 39 kb)
BindingDB Entry 50019167: Structural Alterations of the "Address" Moiety of NAN Leading to the Discovery of a Novel Opioid Receptor Modulator with Reduced hERG Toxicity.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Delta-type opioid receptor, Kappa-type opioid receptor, Mu-type opioid receptor, and Potassium voltage-gated channel subfamily H member 2, Virginia Commonwealth University, Affinity

description: Small molecule binding data for protein Delta-type opioid receptor, Kappa-type opioid receptor, Mu-type opioid receptor, and Potassium voltage-gated channel subfamily H member 2, Uniprot P33534, P41143, P42866, and Q12809
Crematogaster castanea subsp. inversa var. flaviventris
Creators: name: Wheeler, W. M.
Publisher: name: Zenodo
Year: 1922
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Crematogaster
Crematogaster castanea
Crematogaster castanea subspecies inversa variety flaviventris (santschi)

description: Crematogaster castanea subspecies inversa variety flaviventris (Santschi)
Many workers from Garamba (Lang and Chapin), without further data. Both this and the variety analis were originally described from the Belgian Congo. The varietv flaviventris has also been taken in Uganda (C. Alluaud).
description: Published as part of Wheeler, W. M., 1922, The ants collected by the American Museum Congo Expedition., pp. 39-269 in Bulletin of the American Museum of Natural History 45 on page 152
BindingDB Entry 50019166: Small Molecule Inhibitors of Protein Kinase D: Early Development, Current Approaches, and Future Directions.
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2024
Subjects: Serine/threonine-protein kinase D1, Serine/threonine-protein kinase D2, and Serine/threonine-protein kinase D3, University of Pittsburgh, Affinity

description: Small molecule binding data for protein Serine/threonine-protein kinase D1, Serine/threonine-protein kinase D2, and Serine/threonine-protein kinase D3, Uniprot O94806, Q15139, and Q9BZL6
Applied machine learning and the role of dynamic time-series data in optimising clinical management of acute febrile illnesses
Creators: name: Ming, Damien Keng Yen
Publisher: name: Imperial College London
Year: 2023

description: Background Accounting for time-series dependencies inherent in patient healthcare data is important but optimal approaches are not well understood. This thesis investigates the role, and implementation of machine learning models which utilise dynamic data to improve clinical decision-making in acute febrile illnesses. Methods Mixed methods involving data science, qualitative and bioengineering techniques were used. Real-world exemplars including datasets of bacterial bloodstream infections (n=4,198), of dengue (n=4,131) and undifferentiated fever (n=8,100) were analysed using data and machine learning approaches. Clinical implementation of dengue models developed in the thesis was investigated through use of process mapping and thematic analysis. The issues of enhancing patient data acquisition to support future model development were examined through minimally-invasive biosensing techniques. Results Machine learning models which account for time-series dependencies provided better predictive ability compared with time-invariant versions in a range of acute febrile illnesses. Applying such models to healthcare settings required understanding of decision-making processes and patient pathways. Continuous biosensing methods could offer an effective and acceptable approach to enhancing the patient healthcare data collection across different settings. Conclusion The thesis demonstrates the importance of time-series data in supporting clinical decision-making in acute febrile illnesses. Use of novel machine learning methods to enhance existing and routinely collected healthcare information can improve care and is likely to be cost-effective. It is crucial that factors relating to healthcare implementation and data acquisition are addressed to ensure research findings result in clinical impact.