cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Lack of effect of intermittent preventive treatment for malaria in pregnancy and intense drug resistance in western Uganda
Creators: name: Braun, Vera
name: Rempis, Eva
name: Schnack, Alexandra
name: Decker, Sarah
name: Rubaihayo, John
name: Tumwesigye, Nazarius Mbona
name: Theuring, Stefanie
name: Harms, Gundel
name: Busingye, Priscilla
name: Mockenhaupt, Frank P.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2015
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine–pyrimethamine (SP) is widely implemented in sub-Saharan Africa for the prevention of malaria in pregnancy and adverse birth outcomes. However, in areas of intense SP resistance, the efficacy of IPTp may be compromised. Methods A cross-sectional study among 915 delivering women (728 analysable live singleton deliveries) was conducted in Fort Portal, western Uganda, to assess associations of reported IPTp use, Plasmodium falciparum infection, maternal anaemia, low birth weight, and preterm delivery, and to estimate the degree of SP resistance as reflected by pfdhfr/pfdhps mutations. Results Plasmodium falciparum infection was detected by PCR in 8.9 % and by microscopy of placental blood samples in 4.0 %. Infection was significantly associated with stillbirth, early neonatal death, anaemia, low birth weight, and pre-term delivery. Eighty percent of the women had taken at least one dose of IPTp, and more than half had taken two doses. As compared to women without chemoprophylaxis against malaria, IPTp had no significant influence on the presence of P. falciparum infection (13.8 vs. 9.6 %, P = 0.31). Nor was it associated with reductions in anaemia, low birth weight or preterm delivery. P. falciparum with intense SP resistance (pfdhfr/pfdhps quintuple or sextuple mutations) were observed in 93 % (pfdhps 581G, 36 %), and the additional high resistance allele pfhdr 164L in 36 %. Conclusions In Fort Portal, Uganda, reported use of IPTp with SP does not provide an observable benefit. The molecular markers of P. falciparum indicate high grade SP resistance reaching the threshold set by WHO for the discontinuation of IPTp with SP. Alternative approaches for the prevention of malaria in pregnancy are urgently needed.
Aegean Tombs, Sanctuaries, and Figurines
Creators: name: deVito-Brown, Isabella
Publisher: name: Brandeis University
Year: 2023
Subjects: Bronze Age Crete
Bronze Age Cyclades
Funerary Rites
Minoan Religion
Peak Sanctuaries
Votive Figurines

description: This paper analyzes two of the main components of religion on Crete and the Cyclades in the Early to early Late Bronze Age as a way to examine how religious and cultural traditions were shared through the islands. In particular, it discusses the ways in which female votive figurines can be used to analyze the transmission of stylistic traditions and the socio-religious implications of said imported, hybrid, and local figurines. It also examines the construction of sacred spaces, specifically burial sites, peak sanctuaries, palaces, and cave sanctuaries, to understand how religion was practiced and to see if these religious practices were adopted elsewhere.
ФОТОИЛЛЮСТРАЦИИ В НОВОСТНЫХ МАТЕРИАЛАХ ИНТЕРНЕТ-СМИ
Creators: name: Иерусалимова Мария Максимовна
Publisher: name: Медиасреда
Year: 2020
Subjects: визуализация
фотоиллюстрации
фотография
мобильная фотография
средства массовой информации.

description: С развитием интернет-технологий и увеличением количества потребляемой информации визуализация стала одной из ключевых составляющих новостных материалов. Быстрый ритм жизни не позволяет читать новости в большом объеме, в данной ситуации на помощь приходят фотоиллюстрации. В исследовании мы рассмотрим типы визуализации информации, а также на конкретных примерах разберем, в каких случаях в новостных материалах используются фотоиллюстрации.
ИЗОБРАЖЕНИЕ И ОБРАЗ В МЕДИЙНОЙ СРЕДЕ
Creators: name: Коньков Владимир Иванович
Publisher: name: Медиасреда
Year: 2020
Subjects: изображение
образ
очерк
репортаж
социальное пространство-время
хронотоп.

description: Анализируются категории изображения и образа в медийном тексте. Изображение получает статус образа, когда создаётся как воплощение той или иной идеи. Очерк и репортаж с развитым изобразительно-аналитическим началом входят в речевую практику общества дважды: и как информационные тексты, и как образные тексты со своим виртуальным миром, описываемым в рамках категории хронотопа.
ТРАНСФОРМАЦИЯ ТЕЛЕВИЗИОННЫХ ЖАНРОВ НА ПЛОЩАДКЕ YOUTUBE НА ПРИМЕРЕ ДЕЯТЕЛЬНОСТИ АЛЕКСЕЯ ПИВОВАРОВА
Creators: name: Корецкий Михаил Дмитриевич
Publisher: name: Медиасреда
Year: 2020
Subjects: трансформация жанров
видеоблогинг
тележурналистика
YouTube
Алексей Пивоваров.

description: Данная статья посвящена трансформации телевизионных жанров на площадке YouTube. Это происходит путем перехода различных медийных личностей в Интернет. В работе рассмотрены классификации телевизионных и видеоблогерских жанров. Проанализирована деятельность журналиста Алексея Пивоварова. Детально рассмотрены изменения телевизионного жанра на примере видеоматериала, который посвящен подводной лодке «Курск».
ТВОРЧЕСКАЯ КОНЦЕПЦИЯ ПРОГРАММЫ «ПРЯМАЯ ЛИНИЯ С ГУБЕРНАТОРОМ СТАВРОПОЛЬСКОГО КРАЯ» НА РЕГИОНАЛЬНОМ ТЕЛЕКАНАЛЕ «СВОЕ ТВ»
Creators: name: Лепилкина Ольга Ивановна
name: Манаенко Анна Сергеевна
Publisher: name: Медиасреда
Year: 2020
Subjects: региональное телевидение
прямой эфир
телеведущие.

description: В статье на примере программы «Прямая линия с губернатором Ставропольского края» на региональном телеканале «Свое ТВ» рассматривается специфика новой формы взаимодействия регионального телевидения с аудиторией, решения местным каналом функции налаживания социального диалога, характеризуется работа и роль ведущих прямого эфира.
Étude sur le développement des calcrètes de fissures du Yukon septentrional, du pléistocène à aujourd'hui.
Creators: name: Chauret, Yanie.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Physical Geography.

description: Les calcrètes de fissures sont des dépôts de carbonates secondaires que l'on retrouve accolés à l'une des surfaces internes des fissures de la roche calcaire. Si les fissures de la roche où elles se sont développées en sont très riches, elles n'ont jusqu'à maintenant été observées que dans les régions froides et sèches du lac Centrum situé au nord-est du Groënland, ainsi que dans les massifs calcaires du nord du Yukon. Il existe peu d'informations disponibles sur le sujet précis des dépôts de carbonates secondaires localisés dans les fissures de la roche calcaire des régions subarctiques. Par conséquent, l'objectif de la thèse est de déterminer quelles sont les conditions favorables à leur genèse et à leur croissance, ainsi que de dresser un portrait général de l'expression du temps sur leurs micro-structures au cours de leur développement. Pour atteindre cet objectif, une analyse des composantes macroscopiques et microscopiques des calcrètes de fissures a été réalisée sur une série d'échantillons provenant de trois régions calcaires du nord du Yukon: la région de Joe Creek située dans les Monts British, la montagne de Bear Cave ainsi que les calcaires du Dempster Highway situés dans les Monts Ogilvie. (Abstract shortened by UMI.)
CHARACTERIZING ECTOPARASITE DISEASE PRESSURE AND THE UTILITY OF ANTIBODY MARKERS FOR IMMUNE DEFENSE IN POULTRY
Creators: name: Weston, Kendra N.
Publisher: name: Washington State University
Year: 2024
Subjects: Adaptive Antibodies
Natural Antibodies
Organic
Parasites
Poultry
Vaccination
Parasitology

description: Open-environment farms are increasingly popular alternatives to conventional caged poultry farms. However, poultry are at an increased risk of exposure to parasites and pathogens in these alternative farming systems, impacting poultry health and leading to economic losses. Two relevant issues are (1) that pressures from ectoparasites are unknown and (2) the immune metrics used to enhance poultry health are unreliable. As a result, the full extent of disease risk on open-environment farms is unclear and the options for managing infectious diseases are limited. The aim of this study was to (1) determine ectoparasite pressures associated with alternative farming systems, (2) critically analyze methods used to measure natural antibodies (NAbs) as immune indices, and (3) to evaluate purported characteristics of NAbs that are considered important to immune defense. Addressing aim 1, I found all surveyed open-environment farms harbored ectoparasites and there was a higher diversity of ectoparasites on open-environment farms compared to conventional systems. These data supported the growing consensus that infectious disease burdens are elevated in open-environment systems. Addressing aim 2, I compared NAb expression among multiple chicken breeds using different assays reported in the literature. These included hemagglutination-hemolysis assays (HA) and enzyme-linked immunosorbent assays (ELISA). I observed that chicken breed affected NAb levels, but breed effects differed among assays. These results illustrated that assay format may bias interpretations of NAbs and obstruct efforts to use NAbs as immune markers. For aim 3, I conducted experiments to test the assumptions that NAbs do not change in response to immune challenge and that they are correlated with expression of adaptive antibodies (AAbs). I evaluated expression of NAbs and AAbs relative to vaccine challenges of multiple chicken breeds and observed that NAbs change in response to vaccination (i.e., immune challenges). In addition, NAbs were not correlated with AAb expression. These results suggest that persistent assumptions about NAb function are unsupported, which is relevant to ongoing efforts to use NAbs in breeding strategies for enhanced immune defense. These data broaden our understanding of disease pressures in poultry farming and identify important knowledge gaps in immunology that are relevant to managing poultry disease.
Information theoretic aspects of the reliability of binary switching networks.
Creators: name: Farkas, John.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1966
Subjects: subject: Engineering, Electronics and Electrical.

description: The subject of this thesis is the analysis of binary switching networks. Many schemes for improving the performance of an unreliable binary switching element (gate) have been advanced. Only those relying on the combination of many unreliable gates into a more reliable network---performing the original function---are here considered. Some of the well-known schemes are analysed and reduced to a common format. This particular format was selected because it facilitated the application of information theoretic concepts to reliability improvement. Information theoretic concepts, applied under certain restrictions, resulted in the development of a lower bound, LB, on the unreliability (probability of error) of binary switching networks.
ПРОДВИЖЕНИЕ АВТОРСКОЙ ПРОГРАММЫ ЧЕРЕЗ АККАУНТЫ РАДИОВЕДУЩЕГО В СОЦИАЛЬНЫХ СЕТЯХ
Creators: name: Присяжнюк Алина Алексеевна
Publisher: name: Медиасреда
Year: 2020
Subjects: российское разговорное радио
продвижение радиостанции
аудитория
аккаунты радиоведущего
визуализация информации
Instagram.

description: Новая технологическая среда постоянно обновляет список умений радиожурналиста и предъявляет свои требования к работе радиоведущего. Умение грамотно вести собственные профили в разных социальных сетях, разрабатывать их стратегию, анализировать результаты становится жизненно необходимым навыком для привлечения новых слушателей, а также укрепления ядра целевой аудитории радиостанции. Автор статьи рассматривает собственный опыт продвижения авторской радиопрограммы «Голы. Очки. Секунды» через социальную сеть Instagram и пытается выстроить наиболее оптимальный алгоритм действий по продвижению контента радио-станции через профиль радиоведущего.
Defining Violences: Fielding Intimate Partner Violence in Argentina and the United States
Creators: name: Leonard, Samantha
Publisher: name: Brandeis University
Year: 2025
Subjects: comparative
gender
intimate partner violence
slow violence
temporal regimes
Argentina

description: Intimate partner violence is more than a social problem; it is a strategy of power built into contemporary social structures through historical processes of oppression and domination. This dissertation compares two distinct, but related, fields of action against intimate partner violence to analyze how historical processes and social relations produce variances in field dynamics. It focuses on the cases of the intimate partner violence fields in Boston, United States and Buenos Aires, Argentina between 2015-2020. These cases of the intimate partner violence movement in the United States and Argentina are exemplary ones of how a field of action can evolve to include complex and contingent relationships with a variety of social institutions. Specifically, this dissertation focuses on the temporality of these fields of action, introducing the concept of temporal regimes and extending the concept of slow violence in its examination of Boston’s and Buenos Aires’s field of action. In Buenos Aires and Boston, the central organizations Ni Una Menos and Jane Doe Inc. distribute their discursive and material resources according to distinct patterns of temporal orientations. In Boston, the dominant regime is one of prevention; while in Buenos Aires, Ni Una Menos has successfully oriented the field towards a regime of recuperation. In each of these fields, their distinct logics constrain and enable actors in their definitions of gender, violence, and action throughout their encounters with the problem of intimate partner violence. Despite variances between the fields, there are also similarities in the challenges faced by these actors in their work due to the complex temporality of intimate partner violence itself. By extending and complicating the framework of slow violence to these cases, this dissertation analyzes how service providers in both sites navigate these challenges in their definition of the problem, the scope of their work, and the range of their solutions.
ТОЧКИ РОСТА ИММЕРСИВНОЙ ЖУРНАЛИСТИКИ В РОССИИ
Creators: name: Сидунова Мария Константиновна
Publisher: name: Медиасреда
Year: 2020
Subjects: иммерсивная журналистика
визуализация
контент
видео 360
новые медиа.

description: В научной статье рассматриваются сущностные характеристики и тренды иммерсивной журналистики в России и мире. Автор обобщает опыт зарубежных и российских коллег, анализирует материалы, исследует востребованность и возможность использования такого рода контента у аудитории, делает выводы о состоянии журналистики виртуальной реальности в России и указывает точки ее роста.
Mate choice by female house wrens.
Creators: name: Pribil, Stanislav.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1993
Subjects: subject: Biology, Ecology.

description: This study examined female mate choice in the House Wren (Troglodytes aedon). The study was divided into two parts. The first part examined which territory or male traits contribute to female fitness. The second part examined whether females mate non-randomly with respect to those traits. Female fitness (nesting success, number of fledglings, nestling weight) was not related to any territory or male trait. Females mated randomly with respect to all traits except one: they preferred males who arrived early from migration to males who arrived late. However, the date of male arrival was not related to female fitness.
Pseudomonas aeruginosa infection and persistence mechanisms in cystic fibrosis patients
Creators: name: Cameron, Loren Paige
Publisher: name: Imperial College London
Year: 2019

description: Pseudomonas aeruginosa is an environmentally-ubiquitous organism which causes opportunistic infections in humans, with a predisposition towards chronically infecting the cystic fibrosis lung. Its high phenotypic and genotypic plasticity facilitates long-term survival, and chronic P. aeruginosa respiratory infections are associated with increased morbidity and mortality. Understanding the drivers and mechanisms of P. aeruginosa adaptation in relation to disease progression is critical for the development of novel detection methods and treatment strategies. This thesis studies the phenotypic and genotypic adaptation of P. aeruginosa isolates from CF patients, exploring how bacterial characteristics relate to infection stage and severity. By performing whole genome sequence analysis of ten isolates from diverse CF infection backgrounds, common genetic adaptations are identified which occur regardless of infection stage, and analysis of non-coding sequence mutation rate upstream of quorum sensing-regulated genes suggests that certain intragenic sequences may be selectively mutated. This work also investigates whether acute pulmonary exacerbation (or treatment thereof) drives behavioural adaptation of P. aeruginosa, and whether P. aeruginosa phenotypes during these acute periods of infection are similar between patients. Additionally, this work explores the value and implications of detecting P. aeruginosa quorum sensing molecules in respiratory samples. A DNA-encoded biosensor system is optimised for the detection of the P. aeruginosa quorum sensing molecule 3-oxododecanoyl-homoserine lactone (3OC12-HSL) in CF sputum, and an inverse correlation between sputum 3OC12-HSL levels and P. aeruginosa isolate antibiotic resistance is identified. We also report a correlation between quorum sensing and cyclic-di-GMP signalling, relating this to the regulation of biofilm formation and the acute-to-chronic lifestyle switch. Overall, this thesis investigates certain P. aeruginosa lifestyles and adaptations in the context of CF respiratory infection, with a particular focus on the use of quorum sensing signalling – both by the bacterium as a mechanism of lifestyle adjustment, and by us for the monitoring of infections.
Micro-tubular and micro-monolithic solid oxide fuel cells for energy and environment
Creators: name: Bin Rabuni, Mohamad Fairus
Publisher: name: Imperial College London
Year: 2019

description: Micro-tubular solid oxide fuel cells (MT-SOFCs) have interesting features and presents several advantages and competitiveness such as better thermal shock resistance, higher power density and portable characteristics. Further enhancement in terms of cell performance remains as a challenge to be competitive with the planar design made from similar cell materials. In this work, improvement of the anode micro-structure prepared via a phase-inversion assisted process has been studied by employing common SOFC materials including nickel-yttria stabilised zirconia (Ni-YSZ). A new anode design with longer micro-channels and larger pore entrance made using solvent-based bore fluid gave better electrochemical performance compared to the conventional single-channel anode design. Such new design, when utilising YSZ material could be made into a suitable electrolyte scaffold for incorporating anode materials, copper-ceria (Cu-CeO2). MT-SOFC with Cu-based anode was tested for direct methane (CH4) utilisation. Notwithstanding the great potential of MT-SOFC, problems such as low mechanical robustness of the small micro-tube must be addressed. A multi-channel design has been proposed whereby NiO-YSZ anode substrate with various number of channels have been prepared and developed into complete single micro-monolithic cells. Their properties were compared and eventually tested for electrochemical performances. Micro-monolithic design has a better mechanical property, up to 4-8 times compared to the single-channel counterpart. Electrochemical test showed that 7-channel cell achieved about 120 % increment in terms of power density than the conventional single-channel design. The flexibility in the operation of solid oxide electrochemical reactors allows the use of such devices as a fuel cell and electrolyser. Such unique characteristics have been investigated for fuel cell operation with hydrogen (H2) and carbon dioxide (CO2) electrolysis using a novel 6-channel micro-monolithic cell in which excellent performances have been demonstrated.
PROGNOSTIC CHARACTERISTICS OF CERVICAL INSUFFICIENCY IN PREGNANT WOMEN
Creators: name: Tilavova, G.Y.
Publisher: name: Zenodo
Year: 2025

description: The problem of cervical incompetence is becoming increasingly relevant, not only from a medical and biological perspective but also due to its social and economic importance. Preterm infants account for 70% of perinatal deaths and 65-75% of infant mortality. The rates of infant mortality are 8-13 times higher in preterm births compared to term births. According to data, the frequency of cervical incompetence ranges from 0.2% to 2%, accounting for 8-9% of all preterm births. Cervical cerclage is accepted as an effective intervention for pregnancies where a history of previous pregnancy loss or extreme premature delivery indicates a risk of cervical insufficiency.
ПРОФИЛАКТИКА ИНСПЕКТОРИНИНГ КРИМИНОГЕН ВАЗИЯТНИ ЎРГАНИШ ВА ТАҲЛИЛ ҚИЛИШ ФАОЛИЯТИ
Creators: name: Кушбаков, Дилшод
name: Эгамбердиев, Вохиджон
Publisher: name: Zenodo
Year: 2024

description: Ушбу мақолада криминоген вазият тушунчаси криминоген вазиятга таъсир қилувчи психологик омиллар, криминоген вазиятларни таҳлил қилиш ҳамда профилактика инспектори фаолиятидаги мавжуд муаммолар ўрганилиб, уларнинг ечимига доир тавсиялар берилган.
title: Transitional care for rheumatic conditions in Europe
title: current clinical practice and available resources
titleType: Subtitle
Creators: name: Clemente, Daniel
name: Leon, Leticia
name: Foster, Helen
name: Carmona, Loreto
name: Minden, Kirsten
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Transitional care
subject: Rheumatic diseases
subject: Adolescents
subject: Young adults
subject: Chronic disease
subject: Survey method
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Objective To assess European pediatric rheumatology providers’ current clinical practices and resources used in the transition from child-centered to adult-oriented care. Methods European pediatric rheumatologists were invited to complete a 17-item anonymized e-survey assessing current transition practices, transition policy awareness, and needs in advance of the publication of EULAR/PReS recommendations on transition. Results The response rate was 121/276 (44%), including responses from 115 centers in 22 European Union countries. Although 32/121 (26%) responded that their centers did not offer transition services, the majority (99%) agreed that a formalized process in transitioning patients to adult care is necessary. A minority (<30%) of respondents stated that they have a written transition policy although 46% have an informal transition process. Designated staff to support transitional care were available in a minority of centers: nurse (35%), physiotherapist (15%), psychologist (15%), social worker (8%), and occupational therapist (2%). The existence of a designated team member to coordinate transition was acknowledged in many centers (64% of respondents) although just 36% use a checklist for young people as part of individualized transitional care. Conclusion This survey of European pediatric rheumatology providers regarding transitional care practices demonstrates agreement that transitional care is important, and wide variation in current provision of transition services exists.
Assumptions About the Assinnu: Gender, Sex, and Sexuality in Ancient Texts and Modern Scholarship
Creators: name: Ehalt, Kelsie
Publisher: name: Brandeis University
Year: 2021
Subjects: Akkadian
Ancient Mesopotamia
Gender
Sex
Sexuality
Sumerian
Assinnu
Ancient History
Sexuality and Sex Roles

description: Members of the ancient Mesopotamian cult of Ištar have been subjected to various interpretations by scholars despite only a small number of textual references. In scholarly literature, assinnu have been described as everything from cultic prostitutes, to castrates, to “playboys” and “festival people.” This paper will discuss attestations of assinnu in ancient textual sources that have been deployed for various interpretations and translations relating to gender and sexuality. The deepest focus is on the issues of sex assignment at birth, castration, sexuality, prostitution, and transvestism. The incorporation of modern gender theory will aid with deconstructing long-held interpretive traditions within Assyriological scholarship and make space for a new analysis of assinnu as performing a non-normative or non-binary gender. This new, minimal interpretation of assinnu is less dependent on rigid categorization and instead allows room for ambiguity in the ancient texts and modern descriptions of assinnu.
Petrographic and geochemical studies of the alteration zones associated with gold mineralization at the Holloway mine, southwestern Abitibi Greenstone Belt, Canada.
Creators: name: Ropchan, Jean Claudia.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Geochemistry.

description: The Holloway mine is an Archean lode gold deposit hosted within the southwestern Abitibi greenstone belt. Rocks hosting the deposit are bounded by two main branches of the Destor Porcupine fault zone and belong to the Destor Porcupine Complex. Meta-volcanic rocks of the Destor Porcupine Complex were tested using the Treuil method and shown to belong to a tholeiitic suite that differentiated via fractional crystallization producing three distinct groups: tholeiitic meta-basalts, Fe-tholeiitic meta-volcanic rocks, and variolitic meta-volcanic rocks. Alteration at the Holloway deposit consists of a silicified and albitized core surrounded by halos of sericite and carbonate alteration. Carbonate alteration is composed mainly of ankerite and appears pervasive due to many overlapping hydrothermal events. Lightning Zone mineralization is the earlier of two gold mineralizing events. It is associated with finegrained disseminated pyrite and hosted by silicified and albitized variolitic meta-volcanic rocks having variolitic and hyaloclastite textures. Results from statistical factor analysis show that gold-bearing hydrothermal fluids contain S, W, and sometimes As. Both episodes of gold mineralization only occur within meta-volcanic rocks that have a Fe/Mg = 8. (Abstract shortened by UMI.)
Gastrointestinal Tract As Entry Route for Hantavirus Infection
Creators: name: Witkowski, Peter T.
name: Perley, Casey C.
name: Brocato, Rebecca L.
name: Hooper, Jay W.
name: Jürgensen, Christian
name: Schulzke, Joerg-Dieter
name: Krüger, Detlev H.
name: Bücker, Roland
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: hantavirus
subject: puumala virus
subject: hemorrhagic fever with renal syndrome
subject: virus entry
subject: gastrointestinal infection
subject: gastric barrier
subject: tight junction
subject: hamster model
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background: Hantaviruses are zoonotic agents that cause hemorrhagic fevers and are thought to be transmitted to humans by exposure to aerosolized excreta of infected rodents. Puumala virus (PUUV) is the predominant endemic hantavirus in Europe. A large proportion of PUUV-infected patients suffer from gastrointestinal symptoms of unclear origin. In this study we demonstrate that PUUV infection can occur via the alimentary tract. Methods: We investigated susceptibility of the human small intestinal epithelium for PUUV infection and analyzed the resistance of virions to gastric juice. As model for intestinal virus translocation we performed infection experiments with human intestinal Caco-2 monolayers. In animal experiments we infected Syrian hamsters with PUUV via the intragastric route and tested seroconversion and protective immunity against subsequent Andes virus challenge. Results: PUUV retained infectivity in gastric juice at pH >3. The virus invaded Caco-2 monolayers in association with endosomal antigen EEA1, followed by virus replication and loss of epithelial barrier function with basolateral virus occurrence. Cellular disturbance and depletion of the tight junction protein ZO-1 appeared after prolonged infection, leading to paracellular leakage (leak flux diarrhea). Moreover, animal experiments led to dose-dependent seroconversion and protection against lethal Andes virus challenge. Conclusions: We provide evidence that hantavirus can infect the organism via the alimentary tract and suggest a novel aspect of hantavirus infection and pathogenesis. Significance: Hantaviruses are zoonotic pathogens causing severe hemorrhagic fevers worldwide. They are transmitted to humans by small mammals. To date, these viruses were thought to infect exclusively through the airborne route by inhalation of aerosols from infectious animal droppings or by rodent bites. In our work we could show that the alimentary tract is an alternative path of infection for hantaviruses, meaning a new association of virus and disease. These findings have impact on current textbook knowledge and bring many implications for hantavirus epidemiology and outbreak prevention measures.
Video Background Modeling for Efficient Transformations Between Images and Videos
Creators: name: Garber, Solomon E
Publisher: name: Brandeis University
Year: 2023
Subjects: Foreground Subtraction
Lecture Video
Natural Scenes
Video Compression
Video Processing

description: This dissertation presents techniques for generating static representations of video content,which can be used for video compression, video generation, and for allowing users to more
description: efficiently locate information in videos and video databases. These static representations
description: create a correspondence between large video files and concise image representations of their
description: content. In this work I focus on two domains of video, blackboard lecture videos and videos
description: containing background content which exhibits complex dynamic motion. In both instances,
description: there are regularities in the videos which are inherent to the video category, and which can
description: be exploited to create efficient static representations which succinctly describe the content
description: of the video.
description: For blackboard lecture videos, videos are processed to remove the speaker from the fore-
description: ground by detecting regions of the frame where the content is rapidly changing. Once the
description: background video feed has been generated, it is further processed to locate frames before the
description: information is erased from the board, and reduced to a series of slides.
description: In the case of videos containing dynamic background motion, these motions can be de-
description: tected by processing pairs of adjacent frames with optical flow techniques. Using frequency
description: domain analysis, these motions are summarized into static oscillation modes, which can then
description: be used to reanimate still frames from the video in a manner that captures the oscillatory
description: quality of the motion in the original video.
ФРАЗЕОЛОГИЯ В ЗАГОЛОВКАХ ТЕКСТОВ РЕГИОНАЛЬНЫХ ИНТЕРНЕТ-МЕДИА
Creators: name: Старикова Ксения Павловна
Publisher: name: Медиасреда
Year: 2020
Subjects: фразеологические обороты
авторское обновление фразеологизмов
межстилевые
книжные
разговорно-бытовые обороты
оценка
экспрессия.

description: В научной статье исследуются стилистическое разнообразие и экспрессивный потенциал фразеологических единиц в заголовках региональных интернет-медиа на примере сайта cheltv.ru. Автор обобщает опыт российских коллег, на примере эмпирического материала делает выводы о том, какую роль играет стилистическое разнообразие фразеологических оборотов в заголовках региональных интернет-медиа, а также, какое воздействие они оказывают на читателя
Executive function in high functioning individuals with age-associated memory impairment or Alzheimer's disease.
Creators: name: Vasudev, Linda.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Biology, Neuroscience.

description: The purpose of the study was to explore the possibility that age associated memory impairment (AAMI) may form part of a prodromal stage of Alzheimers Disease (AD) through evidence of dysfunction beyond memory, involving also executive function. A sample of subjects meeting AAMI criteria least likely to show executive dysfunction was selected for study by specifying that all participants belonged to a "high functioning" group. As such, all subjects had completed 16 or more years of education. A total of 88 subjects were recruited for the study: 22 young control subjects (YC), 22 older control subjects (OC), 22 subjects with AAMI as specified by the NIMH Work Group criteria, and 22 subjects with mild to moderate probable AD according to NINCDS-ADRDA criteria. The young subjects were recruited to provide appropriate education-based norms for tests of recent memory required for AAMI inclusion criteria. Six executive function tests were used including: Controlled Oral Word Association (COWA), Colour Trails Test (CTT), Similarities subtest of the WAIS-R, Stroop Colour Word Test, Tower of Toronto (TOT), and the Wisconsin Card Sorting Test (WCST). Results indicated the AD group performed significantly worse than both the AAMI and OC groups on all six tests, providing evidence of test sensitivity to executive dysfunction in AD, and confirming the presence of executive function deficits early in the disease course. AAMI and OC groups only differed on the COWA and the TOT. However, when the AAMI subjects were compared to the OC subjects, independent of the AD group, significant differences were found on the COWA, TOT, two indices of the WCST, and CT1. Profile analysis indicated the two groups were not statistically parallel, though examination of the pattern of executive function performance of the AAMI group revealed some similarities to that of the AD sample. It was concluded that AAMI is not merely a mild memory disorder, but that it fulfills to some degree, the criteria of probable AD, and as such, may be a prodromal stage in the development of AD. Current results are deemed particularly important in light of the most recent findings indicating that it is the earliest intervention with anti-dementia compounds which provides the most therapeutic benefit. Thus, the identification of individuals at the prodromal stage of dementia is imperative.
title: (Correction to:) Clinical recommendations for cardiovascular magnetic resonance mapping of T1, T2, T2* and extracellular volume
title: A consensus statement by the Society for Cardiovascular Magnetic Resonance (SCMR) endorsed by the European Association for Cardiovascular Imaging (EACVI)
titleType: Subtitle
Creators: name: Messroghli, Daniel R.
name: Moon, James C.
name: Ferreira, Vanessa M.
name: Grosse-Wortmann, Lars
name: He, Taigang
name: Kellman, Peter
name: Mascherbauer, Julia
name: Nezafat, Reza
name: Salerno, Michael
name: Schelbert, Erik B. [U.A.]
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2018
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Parametric mapping techniques provide a non-invasive tool for quantifying tissue alterations in myocardial disease in those eligible for cardiovascular magnetic resonance (CMR). Parametric mapping with CMR now permits the routine spatial visualization and quantification of changes in myocardial composition based on changes in T1, T2, and T2*(star) relaxation times and extracellular volume (ECV). These changes include specific disease pathways related to mainly intracellular disturbances of the cardiomyocyte (e.g., iron overload, or glycosphingolipid accumulation in Anderson-Fabry disease); extracellular disturbances in the myocardial interstitium (e.g., myocardial fibrosis or cardiac amyloidosis from accumulation of collagen or amyloid proteins, respectively); or both (myocardial edema with increased intracellular and/or extracellular water). Parametric mapping promises improvements in patient care through advances in quantitative diagnostics, inter- and intra-patient comparability, and relatedly improvements in treatment. There is a multitude of technical approaches and potential applications. This document provides a summary of the existing evidence for the clinical value of parametric mapping in the heart as of mid 2017, and gives recommendations for practical use in different clinical scenarios for scientists, clinicians, and CMR manufacturers.
ИНФОРМАЦИОННО-ТЕХНОЛОГИЧЕСКИЕ ОСОБЕННОСТИ ПОЛИТИЧЕСКОГО PR В АСТРАХАНСКОЙ ОБЛАСТИ
Creators: name: Байбатырова Наиля Мунировна
Publisher: name: Медиасреда
Year: 2020
Subjects: Астрахань
политический PR
региональное медиапространство
социальная сеть
информационный портал.

description: В статье исследуются ключевые вопросы информационно-технологического обеспечения политических PR-коммуникаций в российском регионе. Анализируется специфика политической пропаганды и агитации в сети Интернет на примере опыта Астраханской области. Автор подчеркивает, что цели политических технологий находятся в сфере связей с общественностью, и их роль заключается в оптимизации выполнения субъектами политики задач по достижению этих целей.
Convoluted conjugality: Hymnographic repression, transference and co-optation in the Byzantine sanctoral's commemoration of married saints
Creators: name: Butcher, Brian A
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Religion, History of.
subject: Theology.

description: This thesis examines the hymnography of the services for married saints in the Byzantine-Rite Menaion ("Book of Months"), with a view to identifying the theology of marriage that it presents. It is an exercise in liturgical theology, as conceived of by Alexander Schmemann. The first part of the paper introduces the topic, its contemporary relevance and the methodology that will be employed in the study. The second surveys the thought of representative Eastern Orthodox and Byzantine-Rite Catholic theologians regarding marriage, in order to establish a theological reference point for the liturgical analysis of the hymnography. The third part provides a historical contextualization of the theory and practice of marriage in Middle Byzantium and of the development and codification of the Menaion. The hymnographic texts themselves are categorized and critiqued in the fourth part. The thesis concludes with an evaluation of the theology of marriage that obtains in the Menaion, a consideration of its discrepancy with the thought of the theologians surveyed in Part II, and a reflection upon the consequent pastoral implications.
A generic database adapter for multi-tier CORBA-based applications.
Creators: name: Cocard, Remus.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Computer Science.

description: This thesis presents a generic solution to the problem of database adapters for multi-tier CORBA based applications. This solution is based on the concept of metatype classes, which provide information about the types of objects that are being stored in a database. The concept of a metaobject protocol is introduced and discussed. The Database Adapter is proposed as a generic solution for managing persistent information for multi-tier CORBA based applications. A framework for developing multi-tier applications using a generic adapter is presented. A test application is developed to evaluate the management of objects and to measure the impact on performance. It is found that the ability to manage objects through the use of a generic adapter, without modifying the adapter when managing different new types of objects, results in only a slight increase in operation invocation time, but results in huge savings in development and testing time.
ЛИНГВИСТИЧЕСКИЕ БЛОГИ INSTAGRAM: ТЕХНОЛОГИИ РЕКЛАМЫ И ТАКТИКИ ПРОДВИЖЕНИЯ
Creators: name: Гапутина Виолетта Александровна
Publisher: name: Медиасреда
Year: 2020
Subjects: социальная сеть
Instagram
образовательный блог
SMM-продвижение.

description: В статье рассматриваются технологии рекламы блога и тактики его продвижения на примере лингвистического блога @great_russian, созданного на платформе социальной сети Instagram в России. Делается вывод, что технологии, применяемые для популяризации блога, доказывают свою работоспособность, а его контент стимулирует интерес читателей к русскому языку и творческому познанию, способствует повышению уровня грамотности.
Length control, fluctuations, and scaling of actin structures in cells
Creators: name: ALEXIS ROSARIO, ALDRIC ANTO ROSARIO
Publisher: name: Brandeis University
Year: 2023
Subjects: ACTIN
ACTIN CABLES
BUDDING YEAST
LENGTH CONTROL

description: Cells are the fundamental unit of life and make up all the tissues in the body. Just like organs in our body, organelles in cells specialize in a specific function and play a vital role in their survival. The cytoskeleton, one such organelle, extends from the nucleus to the cell membrane performing a multitude of cellular functions: giving cells shape and mechanical resistance to deformation, motility, cell signaling, endocytosis, intracellular transport, segregation of chromosome during cell division, and cytokinesis. Actin is a key cytoskeletal protein and one of the most abundant protein in eukaryotic cells. Actin polymerizes into filaments that bundle into linear structures in vivo such as filopodia at the leading edge of motile cells, stereocilia in inner and outer hair cell bundles, microvilli on the apical surfaces of epithelial cells, and actin cables in budding and fission yeast cells. These structures in vivo turnover rapidly, yet are often maintained at a specific length crucial to realize their cellular functions. Their dynamic nature is exploited in “balance point models” where the assembly or disassembly rates are assumed to be tuned in a length-dependent manner. These models are widely used to explain the length-dependent growth of cytoskeletal filaments. First, we show that these actin structures exhibit a universal scaling of the variance with the square of their mean length in contradiction to the predictions of the balance point model. We propose a model where accounting for the multiple filament nature of these structures can lead to length control even when individual filaments are unregulated. Second, we quantify the distribution of actin associated proteins in wildtype and mutant cells with twice the length of former. Yeast cells build and maintain the length of their actin cables for variable cell lengths. We find a gradient of depolymerizing factor, Srv2 on both the poles of the cell scaling with the length of the cell. This cell size dependent gradient could be a possible mechanism by which cells can scale their cytoskeletal filaments to the linear dimensions of the cell. In addition to scaling gradients, we also find that the distribution is dependent on the actin cytoskeleton itself. This illustrates an amazing cell assembly pathway for organelle length control and scaling where the feedback from the structure and proteins that disassemble these structures could co-regulate each other.
Statistical Properties and Optogenetic Control of Active Turbulence
Creators: name: Lemma, Linnea M
Publisher: name: Brandeis University
Year: 2022

description: The field of active matter seeks to understand how the collective behavior of many animate constituents leads to large-scale organization and dynamics. In this thesis, I studied an active matter system composed of purified cytoskeletal components to examine the statistical properties of the material dynamics and their microscopic origins.
description: First, I quantified the two-dimensional flows of a microtubule-based active nematic liquid crystal and extracted their statistical properties. In agreement with hydrodynamic theory, I found that the vortex areas comprising the turbulent-like flows were exponentially distributed above the `active length scale.'
description: Then, I quantified the dynamics of individual filaments in the active nematic. The extension speed of an isolated microtubule pair was comparable to the molecular motor stepping speed. In contrast, the net extension in dense 2D active nematics was significantly slower; the interfilament sliding speeds were widely distributed about the average and the filaments exhibited both contractile and extensile relative motion. These measurements highlight the challenge of connecting the extension rate of isolated bundles to the multi-motor and multi-filament interactions present in a dense 2D active nematic. They also provide quantitative data that is essential for building multiscale models.
description: Finally, I developed an optogenetic material with photoactivatable control over extensile active stress. Using the optogenetic domain iLID with kinesin-1, I demonstrated a system in which a modified opto-kinesin construct can be used to program extensile active stresses in microtubule networks. The engineered opto-motors provided robust and reversible control over the magnitude of the active stress. Through spatial patterning, I probed the onset of turbulence and found confinement suppressed the bend instability, in agreement with theory. In addition, using this opto-kinesin I created a contracting material in which photoactivation induces a change from contraction to extensile behavior.
ПРОБЛЕМА FAKE NEWS В ИЗБИРАТЕЛЬНЫХ PR-КАМПАНИЯХ АЗИИ, АФРИКИ И ЛАТИНСКОЙ АМЕРИКИ В 2018–2019 ГОДАХ
Creators: name: Гикис Светлана Николаевна
Publisher: name: Медиасреда
Year: 2020
Subjects: fake news
предвыборный PR
зарубежные медиа
антифейковое законодательство
свобода информации

description: В статье анализируется практика использования фальшивых новостей в PR-кампаниях во время выборов 2018–2019 гг. в странах Азии, Африки, Латинской Америки, сравниваются методы борьбы с ними. Рассматриваются антифейковые законодательные инициативы в этих регионах с оценкой их рисков и альтернатив в контексте дилеммы между сохранением гражданских свобод и усилением правительственного контроля.
ВИЗУАЛИЗАЦИЯ В СОЦИАЛЬНЫХ СЕТЯХ КАК СПОСОБ ПРОДВИЖЕНИЯ БРЕНДА МУЗЫКАЛЬНО-ИНФОРМАЦИОННОЙ РАДИОСТАНЦИИ
Creators: name: Исакова Мария Вячеславовна
Publisher: name: Медиасреда
Year: 2020
Subjects: визуализация
социальные сети
продвижение
бренд
музыкально-информационная радиостанция.

description: Автор рассматривает влияние визуализации в социальной сети ВКонтакте на продвижение бренда музыкально-информационных радиостанций. В качестве материала исследования выступили публикации в официальных сообществах федеральных радиостанций FM-формата «Европа Плюс» и «Радио Energy». На основе разработанной классификации были выделены используемые формы визуального контента. Подводя итог, автор замечает, что визуализация в социальных сетях является необходимым способом продвижения бренда музыкально-информационных радиостанций, но, как показывает практика, к нему часто относятся с пренебрежением.