cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Changing–Look Nls1S?
Creators: name: Oknyansky, Victor L.
name: Malanchev, Konstantin L.
name: Gaskell, Martin
Publisher: name: Zenodo
Year: 2018
Subjects: NLS1

description: Two major challenges to unification schemes for AGN activity are the existence of NLS1s and the existence of “changing-look” (CL) AGNs. It is therefore important to look at the relationship between these two phenomena. AGNs can drastically change their spectral appearance in the optical (changing Seyfert type) and/or in the X-ray region. We illustrate the CL phenomenon with our multi-wavelength monitoring of the typical CL object NGC 2617 and discuss its properties compared with NLS1s. There are only a few examples of CL NLS1s and they are mostly changing look only in the X-ray region. Only one NLS1, PS16D (Lanchard et al. 2017), is known to have changed to a broad-line Seyfert1 (BLS1). It has been proposed that this could be a case of a tidal-disruption event (TDE). Low-ionization BLRs have a flat geometry (Gaskell 2009). If, NLS1s are flattened BLR geometries seen face-on (e.g., Decarli et al. 2011), then we will see a changing look only if the orientation of the BLR and accretion disc changes because of a major disruption such as a TDE or a close passage of a secondary black hole. If, as we have suggested (Oknyansky et al. 2015), the hot dust is in a bi-conical outflow, several observational tests can be proposed. Firstly, for NLS1s the lags of H beta and the near IR behind optical/UV continuum variability will be similar, rather than the IR lag being a factor of 3 – 10 times larges as seen in normal BLS1s. The IR response functions should not show the double peaks that are found for some BLS1s. We predict that NLS1s showing a changing look in the optical should be very rare; only X-ray or TDE CL cases should be seen, as seems to be the case. An interesting problem is why NLS1 are less variable in UV and optical regions yet strongly variable in X-ray (Klimek et al. 2004). If NLS1s include both high Eddington rate accretion and low-inclination AGNs (e.g., Peterson 2011) then a significant fraction of NLS1s could be obscured and would not be identified as NLS1s. CL cases might happen more often if there is dust sublimation following a strong increase in the optical luminosity that causes some obscured NLS1s to become unobscured.
COVID-19 Image Data Collection: Prospective Predictions Are the Future
Creators: name: Cohen, Joseph Paul
name: Morrison, Paul
name: Dao, Lan
name: Roth, Karsten
name: Duong, Tim Q
name: Ghassemi, Marzyeh
Publisher: name: arXiv
Year: 2020
Subjects: subject: Quantitative Methods (q-bio.QM)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Machine Learning (cs.LG)
subject: Image and Video Processing (eess.IV)
subject: FOS: Biological sciences
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Across the world's coronavirus disease 2019 (COVID-19) hot spots, the need to streamline patient diagnosis and management has become more pressing than ever. As one of the main imaging tools, chest X-rays (CXRs) are common, fast, non-invasive, relatively cheap, and potentially bedside to monitor the progression of the disease. This paper describes the first public COVID-19 image data collection as well as a preliminary exploration of possible use cases for the data. This dataset currently contains hundreds of frontal view X-rays and is the largest public resource for COVID-19 image and prognostic data, making it a necessary resource to develop and evaluate tools to aid in the treatment of COVID-19. It was manually aggregated from publication figures as well as various web based repositories into a machine learning (ML) friendly format with accompanying dataloader code. We collected frontal and lateral view imagery and metadata such as the time since first symptoms, intensive care unit (ICU) status, survival status, intubation status, or hospital location. We present multiple possible use cases for the data such as predicting the need for the ICU, predicting patient survival, and understanding a patient's trajectory during treatment. Data can be accessed here: https://github.com/ieee8023/covid-chestxray-dataset
description: Accepted for publication at the Journal of Machine Learning for Biomedical Imaging (MELBA) https://melba-journal.org. Code for baseline experiments can be found here: https://github.com/mlmed/covid-baselines
Tick-Borne Encephalitis Virus Replication, Intracellular Trafficking, and Pathogenicity in Human Intestinal Caco-2 Cell Monolayers
Creators: name: Yu, Chao
name: Achazi, Katharina
name: Möller, Lars
name: Schulzke, Jörg D.
name: Niedrig, Matthias
name: Bücker, Roland
Publisher: name: Robert Koch-Institut, Biologische Sicherheit
Year: 2014
Subjects: subject: Humans
subject: Virus Replication
subject: Virulence
subject: Biological Transport
subject: Caco-2 Cells
subject: Cytoskeleton/virology
subject: Encephalitis Viruses Tick-Borne/metabolism
subject: Encephalitis Viruses Tick-Borne/pathogenicity
subject: Encephalitis Viruses Tick-Borne/physiology
subject: Intestines/cytology
subject: Intestines/ultrastructure
subject: Intestines/virology
subject: Intracellular Space/virology
subject: Pinocytosis
subject: Virus Internalization
subject: 610 Medizin

description: Tick-borne encephalitis virus (TBEV) is one of the most important vector-borne viruses in Europe and Asia. Its transmission mainly occurs by the bite of an infected tick. However, consuming milk products from infected livestock animals caused TBEV cases. To better understand TBEV transmission via the alimentary route, we studied viral infection of human intestinal epithelial cells. Caco-2 cells were used to investigate pathological effects of TBEV infection. TBEV-infected Caco-2 monolayers showed morphological changes including cytoskeleton rearrangements and cytoplasmic vacuolization. Ultrastructural analysis revealed dilatation of the rough endoplasmic reticulum and further enlargement to TBEV containing caverns. Caco-2 monolayers maintained an intact epithelial barrier with stable transepithelial electrical resistance (TER) during early stage of infection. Concomitantly, viruses were detected in the basolateral medium, implying a transcytosis pathway. When Caco-2 cells were pre-treated with inhibitors of cellular pathways of endocytosis TBEV cell entry was efficiently blocked, suggesting that actin filaments (Cytochalasin) and microtubules (Nocodazole) are important for PI3K-dependent (LY294002) virus endocytosis. Moreover, experimental fluid uptake assay showed increased intracellular accumulation of FITC-dextran containing vesicles. Immunofluorescence microscopy revealed co-localization of TBEV with early endosome antigen-1 (EEA1) as well as with sorting nexin-5 (SNX5), pointing to macropinocytosis as trafficking mechanism. In the late phase of infection, further evidence was found for translocation of virus via the paracellular pathway. Five days after infection TER was slightly decreased. Epithelial barrier integrity was impaired due to increased epithelial apoptosis, leading to passive viral translocation. These findings illuminate pathomechanisms in TBEV infection of human intestinal epithelial cells and viral transmission via the alimentary route.
Additional file 5 of Combining GWAS and comparative genomics to fine map candidate genes for days to flowering in mung bean
Creators: name: Chiteri, Kevin O.
name: Rairdin, Ashlyn
name: Sandhu, Kulbir
name: Redsun, Sven
name: Farmer, Andrew
name: O’Rourke, Jamie A.
name: Cannon, Steven B.
name: Singh, Arti
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 5.
Additional file 6 of Combining GWAS and comparative genomics to fine map candidate genes for days to flowering in mung bean
Creators: name: Chiteri, Kevin O.
name: Rairdin, Ashlyn
name: Sandhu, Kulbir
name: Redsun, Sven
name: Farmer, Andrew
name: O’Rourke, Jamie A.
name: Cannon, Steven B.
name: Singh, Arti
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 6.
THE SIGNIFICANCE OF FORMING ECOLOGICAL CONCEPTS IN TEACHING NATURAL SCIENCES TO PRIMARY CLASSES
Creators: name: Kudyarova Artikgul Student of the Faculty of primary education of The Nukus State Pedagogical Institute named after Ajiniyaz
Publisher: name: Zenodo
Year: 2024

description: In this article, the development of an excellent system of environmental education and its introduction into the educational system, the reduction of anthropogenic damage to nature, the main principles of environmental education, the improvement of elementary school students' understanding of ecology based on a creative approach, the main focus is on the environment. - Issues such as environmental protection, rational and economical use of nature will be discussed.

Kеywоrds: lesson, student, environmental policy, nature, society, cultural heritage.
Additional file 7 of Combining GWAS and comparative genomics to fine map candidate genes for days to flowering in mung bean
Creators: name: Chiteri, Kevin O.
name: Rairdin, Ashlyn
name: Sandhu, Kulbir
name: Redsun, Sven
name: Farmer, Andrew
name: O’Rourke, Jamie A.
name: Cannon, Steven B.
name: Singh, Arti
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 7.
Management of pregnant women infected with Ebola virus in a treatment centre in Guinea, June 2014
Creators: name: Baggi, F. M.
name: Taybi, A.
name: Kurth, Andreas
name: Herp, M. Van
name: Caro, A. Di
name: Wölfel, Roman
name: Günther, Stephan
name: Decroo, T.
name: Declerck, H.
name: Jonckheere, S.
Publisher: name: Robert Koch-Institut, Biologische Sicherheit
Year: 2014
Subjects: subject: Humans
subject: Female
subject: Adult
subject: Treatment Outcome
subject: Infant Newborn
subject: Reverse Transcriptase Polymerase Chain Reaction
subject: Antiviral Agents/therapeutic use
subject: Pregnancy
subject: Amniocentesis
subject: Delivery Obstetric
subject: Ebolavirus/genetics
subject: Ebolavirus/isolation & purification
subject: Guinea
subject: Hemorrhagic Fever Ebola/diagnosis
subject: Hemorrhagic Fever Ebola/drug therapy
subject: Pregnancy Complications Infectious/drug therapy
subject: Pregnancy Complications Infectious/virology
subject: Pregnancy Outcome
subject: 610 Medizin

description: We report two cases of confirmed Ebola virus disease in pregnant women, who presented at the Médecins Sans Frontières Ebola treatment centre in Guéckédou. Despite the very high risk of death, both pregnant women survived. In both cases the critical decision was made to induce vaginal delivery. We raise a number of considerations regarding the management of Ebola virus-infected pregnant women, including the place of amniocentesis and induced delivery, and whether certain invasive medical acts are justified.
2022-05-31_Befragung der MCSP-TN 2022 _Uebersicht
Creators: name: Reimer, Maike
name: Elhalaby, Christina
name: Illmer, Stefanie
Publisher: name: Zenodo
Year: 2022
Subjects: Clinician Scientists
Evaluation

description: Overview of an evaluative survey among clinician scientists participating in the Munich Clinician Scientist Program (MCSP) at the Ludwig-Maximilians-Universität München (LMU), conducted by the Bayerisches Staatsinstitut für Hochschulforschung und Hochschulplanung (IHF), conducted in 2022 Further information: https://www.med.uni-muenchen.de/karriere/mcsp/index.html [German] https://www.researchgate.net/project/Clinician-Scientists-Project-CSP
High Prevalence and High Incidence of Coinfection with Hepatitis B, Hepatitis C, and Syphilis and Low Rate of Effective Vaccination against Hepatitis B in HIV-Positive Men Who Have Sex with Men with Known Date of HIV Seroconversion in Germany
Creators: name: Jansen, Klaus
name: Thamm, Michael
name: Bock, Thomas
name: Scheufele, Ramona
name: Kücherer, Claudia
name: Muenstermann, Dieter
name: Hagedorn, Hans-Jochen
name: Jessen, Heiko
name: Dupke, Stephan
name: Hamouda, Osamah
name: Gunsenheimer-Bartmeyer, Barbara
name: Meixenberger, Karolin
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2015
Subjects: subject: Germany
subject: Humans
subject: Male
subject: Adolescent
subject: Adult
subject: Aged
subject: Middle Aged
subject: Young Adult
subject: HIV Infections/complications
subject: HIV Infections/epidemiology
subject: Prevalence
subject: Incidence
subject: Homosexuality Male
subject: Hepatitis B/complications
subject: Hepatitis B Vaccines/administration & dosage
subject: Hepatitis C/complications
subject: Seroconversion
subject: Syphilis/complications
subject: 610 Medizin

description: Objectives: Men who have sex with men (MSM) are at higher risk for coinfection with hepatitis B virus (HBV), hepatitis C virus (HCV), and syphilis than the general population. HIV infection and these coinfections accelerate disease progression reciprocally. This study evaluated the prevalence and incidence of these coinfections in HIV1-positive MSM in Germany. Materials and Methods: As part of a nationwide, multicenter, prospective cohort study of HIV-infected MSM, plasma samples collected yearly were screened for HBsAg and antibodies to HBc, HBs, HCV, and syphilis. Samples with indications of active HBV or HCV infection were confirmed by polymerase chain reaction. Prevalence and incidence of each infection and incidence rates per study participant were calculated, and incidences over 4-year time intervals compared. Results: This study screened 5,445 samples from 1,843 MSM. Median age at HIV seroconversion was 33 years. Prevalences of active, cleared, and occult HBV, and of active/cleared HCV were 1.7%, 27.1%, 0.2%, and 8.2%, respectively, and 47.5% had been effectively vaccinated against HBV. Prevalence of antibodies to Treponema pallidum and of triple or quadruple sexually transmitted infections (STIs) were 39.6% and 18.9%, respectively. Prevalence of STI, cleared HBV, HBV vaccination, and history of syphilis differed significantly among age groups. Incidences of HBV, HCV, and syphilis were 2.51, 1.54, and 4.06 per 100 person-years, respectively. Incidences of HCV and syphilis increased over time. HCV incidence was significantly higher in MSM coinfected with syphilis and living in Berlin, and syphilis incidence was significantly higher for MSM living in Berlin. Discussion: Despite extensive HBV vaccination campaigns, fewer than 50% of screened MSM were effectively vaccinated, with a high proportion of HIV-positive MSM coinfected with HBV. High rates of STI coinfections in HIV-positive MSM and increasing incidences emphasize the need for better tailored campaigns for HBV vaccination and STI prevention.
Additional file 1 of Tree peony transcription factor PrWRI1 enhances seed oil accumulation
Creators: name: Xie, Lihang
name: Hu, Jiayuan
name: Yan, Zhenguo
name: Li, Xinyao
name: Wei, Sailong
name: Xu, Ruilin
name: Yang, Weizong
name: Gu, Huihui
name: Zhang, Qingyu
Publisher: name: figshare
Year: 2024
Subjects: subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 1: Supplementary Table 1. Primers used for gene isolation and vector construction in the present study. Supplementary Table 2. Primers used for qRT-PCR analysis in the present study. Supplementary Table 3. The correlation analysis on the expression trends between WRI1 and other genes relating to fatty acid biosynthesis in developing P. rockii seeds based on the transcriptome data.
Clostridium difficile ribotypes 001, 017, and 027 are associated with lethal C. difficile infection in Hesse, Germany
Creators: name: Arvand, M.
name: Hauri, Anja M.
name: Zaiß, Henning
name: Witte, Wolfgang
name: Bettge-Weller, G.
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2009
Subjects: subject: Adult
subject: 80 and over
subject: Humans
subject: Female
subject: Polymerase Chain Reaction
subject: Disease Outbreaks
subject: Germany/epidemiology
subject: Virulence
subject: Male
subject: Middle Aged
subject: Incidence
subject: Population Surveillance
subject: Clostridium difficile/classification
subject: Clostridium difficile/isolation & purification
subject: Enterocolitis
subject: Ribotyping
subject: Aged
subject: Pseudomembranous/microbiology
subject: Cross Infection/microbiology
subject: Cross Infection/epidemiology
subject: Mandatory Reporting
subject: Bacterial Toxins/analysis
subject: Clostridium difficile/pathogenicity
subject: Pseudomembranous/mortality
subject: Enterotoxins/analysis
subject: Feces/microbiology
subject: Megacolon
subject: Toxic/microbiology
subject: Toxic/mortality
subject: Toxic/surgery
subject: 610 Medizin

description: From January 2008 to April 2009, 72 cases of severe Clostridium difficile infection were reported from 18 different districts in the state of Hesse, Germany. A total of 41 C. difficile isolates from 41 patients were subjected to PCR ribotyping. PCR ribotype (RT) 027 was the most prevalent strain accounting for 24 of 41 (59%) of typed isolates, followed by RT 001 (eight isolates, 20%), RT 017 and 042 (two isolates each), and RT 003, 066, 078, 081, and RKI-034 (one isolate each). Eighteen patients had died within 30 days after admission. C. difficile was reported as underlying cause of or contributing to death in 14 patients, indicating a case fatality rate of 19%. The patients with lethal outcome attributable to C. difficile were 59-89 years-old (median 78 years). Ribotyping results were available for seven isolates associated with lethal outcome, which were identified as RT 027 in three and as RT 001 and 017 in two cases each. Our data suggest that C. difficile RT 027 is prevalent in some hospitals in Hesse and that, in addition to the possibly more virulent RT 027, other toxigenic C. difficile strains like RT 001 and 017 are associated with lethal C. difficile infections in this region.
Coordinated Implementation of Chikungunya Virus Reverse Transcription–PCR.
Creators: name: Panning, Marcus
name: Charrel, Remi N.
name: Mantke, Oliver Donoso
name: Landt, Olfert
name: Niedrig, Matthias
name: Drosten, Christian
Publisher: name: Robert Koch-Institut, Biologische Sicherheit
Year: 2009
Subjects: subject: Humans
subject: RNA
subject: Viral/analysis
subject: Quality Control
subject: Sensitivity and Specificity
subject: Reverse Transcriptase Polymerase Chain Reaction/methods
subject: Europe
subject: Alphavirus Infections/diagnosis
subject: Alphavirus Infections/virology
subject: Chikungunya virus/genetics
subject: Chikungunya virus/isolation & purification
subject: Chikungunya virus/metabolism
subject: Reagent Kits
subject: Diagnostic
subject: 610 Medizin

description: A preformulated chikungunya virus real-time reverse transcription-PCR, quality-confirmed oligonucleotides, and noninfectious virus controls were distributed by the European Network for the Diagnosis of Imported Viral Diseases. An international proficiency study with 31 participants demonstrated that ad hoc implementation of molecular diagnostics was feasible and successful.
Additional file 4 of Improved weed segmentation in UAV imagery of sorghum fields with a combined deblurring segmentation model
Creators: name: Genze, Nikita
name: Wirth, Maximilian
name: Schreiner, Christian
name: Ajekwe, Raymond
name: Grieb, Michael
name: Grimm, Dominik G.
Publisher: name: figshare
Year: 2024
Subjects: subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences

description: Additional file 4. Insufficient cases of the deblurring step.
Ειδικά ζητήματα του δικαίου των προσωπικών δεδομένων
Creators: name: Γιαννούση, Γεωργία
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2024
Subjects: subject: Δίκαιο προσωπικών δεδομένων
subject: Γενικός Κανονισμός Προστασίας Δεδομένων (ΓΚΠΔ)

description: Το δίκαιο των προσωπικών δεδομένων και η εφαρμογή του Γενικού Κανονισμού Προστασίας Δεδομένων, γνωστού και ως GDPR, αποτελεί το αντικείμενο της παρούσας εργασίας. Στο πρώτο κεφάλαιο παρουσιάζεται ο ΓΚΠΔ, ο οποίος διαδραμάτισε καθοριστικό ρόλο στην αλλαγή της καθημερινότητας όχι μόνο των φυσικών προσώπων, αλλά και των επιχειρήσεων ωθώντας τους στην υιοθέτηση νέων συνηθειών και πρακτικών. Επιπλέον γίνεται αναφορά στο πως το εθνικό μας Σύνταγμα προστατεύει το δικαίωμα στα προσωπικά δεδομένα. Στο δεύτερο κεφάλαιο της παρούσης δίνεται έμφαση σε ορισμένες ρυθμίσεις του Κανονισμού, οι οποίες παρουσιάζουν έντονο ενδιαφέρον και εισάγουν καινοτομίες σε σχέση με το προηγούμενο καθεστώς, ενώ ταυτόχρονα ενισχύουν την θέση των υποκειμένων των δεδομένων και παρέχουν μεγαλύτερο εύρος προστασίας. Πρόκειται για μία ανάλυση των δικαιωμάτων των υποκειμένων των δεδομένων κάνοντας ειδική μνεία στα δικαιώματα των παιδιών. Στο τρίτο κεφάλαιο, έπειτα της ανάλυσης των αρχών που διέπουν των Κανονισμό, και ειδικά της αρχής της λογοδοσίας, η παρουσίαση της εθνικής Αρχής Προστασίας Προσωπικών Δεδομένων και το πως κάποιος μπορεί να προσφύγει σε αυτή. Στο τέταρτο κεφάλαιο βρίσκονται κάποιες πρόσφατες αποφάσεις της εποπτικής αρχής, οι οποίες μας βοηθούν να κατανοήσουμε το πως εφαρμόζεται στην πράξη ο Κανονισμός και φυσικά πόσο αυστηρές είναι οι κυρώσεις που επιβάλλονται από την Αρχή Προστασίας Δεδομένων. Τέλος στο δεύτερο μέρος της εργασίας γίνεται μία προσπάθεια, ώστε να γίνει αντιληπτή η παρουσία και τα οφέλη της εφαρμογής του σε διάφορους τομείς της ζωής μας, όπως στην εργασία, στον τομέα της υγείας και φυσικά στο διαδίκτυο που τόσο πολύ έχει επηρεάσει την καθημερινότητα μας και αποτελεί αναπόσπαστο μέρος της.
Sensory fatigue: militarization, redevelopment and state exceptionalism in Kingston Jamaica
Creators: name: Walker, Tashanna Jolene
Publisher: name: No Publisher Supplied
Year: 2024

description: This dissertation looks at power, domination, and resistance amongst the urban underclass in Kingston, Jamaica, within the context of postcolonial struggles of state legitimacy and economic competitiveness through increased practices of militarization and exceptional forms of policing. Using data retrieved from archival sources and ethnographic methods, this project investigated how, at the macro level, punitive security policies, specifically reasserts state power as a path for economic development for the most marginalized while simultaneously drawing existing contradictions of Jamaican urban political life into the formal space of urban governance. Given that the military is being used as security infrastructure to regulate urban life, at the micro-level, this project examined the effects of this militarization on residents. I lived in Trench Town for twelve consecutive months, observing residents’ everyday movements in highly constrained conditions, focusing on how and where state control manifested, and how households and families adapted and reshaped their urban environments. Using various participatory methods as well as knowledge from my own lived experience in Trench Town, I was able to understand and appreciate the complexities of their everyday urban experiences, increasingly shaped by conditions of extreme violence, militarization, and state surveillance. My research adopts a multidisciplinary approach that draws from theoretical and methodological perspectives from various fields, including environmental justice, critical development studies, postcolonial and urban geography, Black geographical scholarship, and Caribbean studies. Drawing critical inspiration from the histories of social and environmental struggle in multiple compromised environments, attending to practices of Black space making, and experimenting with decolonial qualitative methodologies, this research project challenges dominant ways of knowing by centering local knowledge and experiences. The central novel idea posited in this dissertation is the idea of sensory fatigue, which is the situational cognitive-interpretative as well as affective response to the layered excesses of militarization, poverty, and gang violence.
title: Ο ρόλος των έξυπνων πόλεων σαν εργαλεία περιφερειακής ανάπτυξης
title: The role of smart cities as tools of regional development
titleType: AlternativeTitle
Creators: name: Παπαδόπουλος, Γεώργιος
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2024
Subjects: subject: Έξυπνες πόλεις
subject: Περιφερειακή ανάπτυξη
subject: Στόχοι Βιώσιμης Ανάπτυξης
subject: Smart cities
subject: Regional development
subject: SDGs

description: Ξεκινώντας με το πρώτο κεφάλαιο, δίνεται ο ορισμός και τα στοιχεία της πόλης και της αστικοποίησης, ως κοινωνικό φαινόμενο. Στη συνέχεια, η εργασία επικεντρώνεται στον ορισμό της «έξυπνης» πόλης και στα χαρακτηριστικά γνωρίσματα και τη δομή αυτής. Σε αυτή την ενότητα τονίζεται η διαδρομή εξέλιξής της, καθώς και οι παράγοντες επιτυχίας. Επιπλέον στοιχείο που αναλύεται είναι η στάση της ΕΕ σχετικά με το εν λόγω ζήτημα και οι διαστάσεις και τα όρια της στρατηγικής της. Το τρίτο κεφάλαιο εξετάζει την έννοια της περιφερειακής ανάπτυξης και της βιωσιμότητας. Μέσα από την παράθεση των στόχων του ΟΗΕ για τη βιώσιμη ανάπτυξη, επιχειρείται να γίνει μια διασύνδεση της βιωσιμότητας, της περιφερειακής ανάπτυξης και των «έξυπνων πόλεων». Επιπλέον παρουσιάζεται ο βαθμός στον οποίο οι σύγχρονες πόλεις πλησιάζουν τους συγκεκριμένους στόχους. Το τέταρτο κεφάλαιο παρουσιάζονται κάποια παραδείγματα «έξυπνων» πόλεων σε Ευρωπαϊκή Ένωση και Ελλάδα, όπου συμπεραίνεται ότι κάποιες εξ αυτών έχουν κάνει ήδη σοβαρή προσπάθεια προς αυτή την κατεύθυνση. Ακολουθεί μια παράθεση προτάσεων για το μετασχηματισμό μιας πόλης σε «έξυπνη» και βιώσιμη και φιλικότερη στο περιβάλλον. Στο τελευταίο κεφάλαιο της εργασίας, παρουσιάζονται τα συμπεράσματα, που έχουν εξαχθεί από το σύνολο αυτής.
Vitamin D status and health correlates among German adults
Creators: name: Hintzpeter, Birte
name: Mensink, Gert
name: Thierfelder, Wulf
name: Müller, MJ
name: Scheidt-Nave, Christa
Publisher: name: Robert Koch-Institut; Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2007
Subjects: subject: Adolescent
subject: Humans
subject: Female
subject: Germany/epidemiology
subject: Male
subject: Middle Aged
subject: Body Mass Index
subject: Risk Factors
subject: Adult
subject: Aged
subject: Seasons
subject: Vitamin D Deficiency/epidemiology
subject: Linear Models
subject: Nutrition Surveys
subject: Nutritional Status
subject: Young Adult
subject: Calcium/blood
subject: Dietary Supplements
subject: Parathyroid Hormone/blood
subject: Vitamin D/analogs & derivatives
subject: Vitamin D/blood
subject: Vitamin D Deficiency/complications
subject: Vitamin D Deficiency/prevention & control
subject: 610 Medizin

description: Objective: To analyze vitamin D status based on serum 25-hydroxyvitamin D (25OHD) measurements, its determinants and health correlates in a representative sample of German adults. Subjects: A total of 1763 men and 2267 women, 18- to 79-year old, who participated in the representative German National Health Interview and Examination Survey 1998 and the integrated German Nutrition Survey. Results: The median vitamin D intake from both diet and supplements did not meet the recommended level of 5 microg/day, in either men (2.8 microg/day) or women (2.3 microg/day). Altogether 80.9% of men and 88.5% of women had vitamin D intakes below this level. Moderate (12.5-25 nmol/l serum 25OHD levels) and mild (25-50 nmol/l) vitamin D deficiency was prevalent in the adult population in Germany, even in younger age groups. Overall, 57% of men and 58% of women had vitamin D levels below 50 nmol/l. Among 65- to 79-year-old women, the proportion amounted to 75%, even during the sunnier half of the year. In sex-specific multiple linear regression models, independent determinants of serum 25OHD levels consistently included season, vitamin D intake from both diet and supplements, physical activity and living in a partnership. In addition, age and current menopausal hormone use contributed to the model among women, as opposed to time of day of blood sampling and body mass index (marginally) among men. Significantly lower serum 25OHD levels were observed in women with hypertension, cardiovascular diseases and noninsulin-treated diabetes mellitus as well as in men with insulin-treated diabetes mellitus compared with nonaffected participants. Conclusions: Vitamin D deficiency is a public health issue in Germany. We identified a number of determinants with potential for primary prevention of vitamin D deficiency. Risk and benefits of preventive actions need to be examined in further studies.
German cancer statistics 2004
Creators: name: Haberland, Jörg
name: Bertz, Joachim
name: Wolf, Ute
name: Ziese, Thomas
name: Kurth, Bärbel-Maria
Publisher: name: Robert Koch-Institut
Year: 2010
Subjects: subject: Adult
subject: Humans
subject: Female
subject: Germany
subject: Male
subject: Middle Aged
subject: Aged
subject: Cause of Death
subject: Medical Oncology/trends
subject: Medical Records
subject: Neoplasms/diagnosis
subject: Neoplasms/epidemiology
subject: Neoplasms/mortality
subject: 610 Medizin

description: Background: For years the Robert Koch Institute (RKI) has been annually pooling and reviewing the data from the German population-based cancer registries and evaluating them together with the cause-of-death statistics provided by the statistical offices. Traditionally, the RKI periodically estimates the number of new cancer cases in Germany on the basis of the available data from the regional cancer registries in which registration is complete; this figure, in turn, forms the basis for further important indicators. Methods: This article gives a brief overview of current indicators - such as incidence, prevalence, mortality, survival rates - on the most common types of cancer, as well as important ratios on the risks of developing and dying of cancer in Germany. Results: According to the latest estimate, there were a total of 436,500 new cancer cases in Germany in 2004. The most common cancer in men is prostate cancer with over 58,000 new cases per annum, followed by colorectal and lung cancer. In women, breast cancer remains the most common cancer with an estimated 57,000 new cases every year, also followed by colorectal cancer. These and further findings on selected cancer sites can be found in the current brochure on “Cancer in Germany”, which is regularly published by the RKI together with the Association of Population-based Cancer Registries in Germany (GEKID). In addition, the RKI made cancer-prevalence estimates and calculated current morbidity and mortality risks at the federal level for the first time. According to these figures, the 5-year partial prevalence - i.e. the total number of cancer patients diagnosed over the past five years who are currently still living - exceeds 600,000 in men; the figure is about the same among women. Here, too, the most common cancers are prostate cancer in men and breast cancer in women. The lifetime risk of developing cancer, which is more related to the individual, is estimated to be higher among men (48.5%) than among women (40.3%). In roughly rounded figures, therefore, about every second person in Germany develops cancer in the course of their lives. One in four men and one in five women die of cancer. Conclusions: In recent years, population-based cancer registration in Germany has come significantly closer to the aim of the complete, nationwide coverage of cancer. The continuous improvements in the data situation help describe cancer development in Germany.
Supplemental Material, sj-pdf-1-jic-10.1177_08850666211024139 - Closed-Loop Versus Conventional Mechanical Ventilation in COVID-19 ARDS
Creators: name: Wendel Garcia, Pedro David
name: Hofmaenner, Daniel Andrea
name: Brugger, Silvio D.
name: Acevedo, Claudio T.
name: Bartussek, Jan
name: Camen, Giovanni
name: Bader, Patrick Raphael
name: Bruellmann, Gregor
name: Kattner, Johannes
name: Ganter, Christoph
name: Schuepbach, Reto Andreas
name: Buehler, Philipp Karl
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110305 Emergency Medicine
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 110203 Respiratory Diseases

description: Supplemental Material, sj-pdf-1-jic-10.1177_08850666211024139 for Closed-Loop Versus Conventional Mechanical Ventilation in COVID-19 ARDS by Pedro David Wendel Garcia, Daniel Andrea Hofmaenner, Silvio D. Brugger, Claudio T. Acevedo, Jan Bartussek, Giovanni Camen, Patrick Raphael Bader, Gregor Bruellmann, Johannes Kattner, Christoph Ganter, Reto Andreas Schuepbach and Philipp Karl Buehler in Journal of Intensive Care Medicine
Data from: The potential for evolutionary rescue in an arctic seashore plant threatened by climate change
Creators: name: Mattila, Anniina L. K.
name: Opedal, Øystein H.
name: Hällfors, Maria H.
name: Pietikäinen, Laura
name: Koivusaari, Susanna H. M.
name: Hyvärinen, Marko-Tapio
Publisher: name: Zenodo
Year: 2024
Subjects: evolvability
evolutionary rescue
G-matrix
Primula nutans
climate change adaptation

description: The impacts of climate change may be particularly severe for geographically isolated populations, which must adjust through plastic responses or evolve. Here, we study an endangered arctic plant, Primula nutans ssp. finmarchica, confined to Fennoscandian seashores and showing indications of maladaptation to a warming climate. We evaluate the potential of these populations to evolve to facilitate survival in the rapidly warming Arctic (i.e. evolutionary rescue) by utilizing manual crossing experiments in a nested half-sibling breeding design. We estimate G-matrices, evolvability, and genetic constraints in traits with potentially conflicting selection pressures. To explicitly evaluate the potential for climate change adaptation, we infer the expected time to evolve from a northern to a southern phenotype under different selection scenarios, using demographic and climatic data to relate expected evolutionary rates to projected rates of climate change. Our results indicate that, given the nearly ten-fold greater evolvability of vegetative than of floral traits, adaptation in these traits may take place nearly in concert with changing climate, given effective climate mitigation. However, the comparatively slow expected evolutionary modification of floral traits may hamper the evolution of floral traits to track climate-induced changes in the pollination environment, compromising sexual reproduction and thus reducing the likelihood of evolutionary rescue.
description: Funding provided by: Research Council of FinlandROR ID: https://ror.org/05k73zm37Award Number: 331527
description: Trait data of Primula nutans ssp. finmarchica common-garden cultivated plant individuals, both of parental (P) generation collected from the field in northern Finland (southern populations: populations B and E) and Norway (northern population: population G), and of F1 generation which are offspring of manual crossings of P generation according to a nested half-sibling/full-sibling crossing design.
sj-docx-2-msj-10.1177_13524585211020296 – Supplemental material for Differential association of cortical, subcortical and spinal cord damage with multiple sclerosis disability milestones: A multiparametric MRI study
Creators: name: Hidalgo de la Cruz, Milagros
name: Valsasina, Paola
name: Meani, Alessandro
name: Gallo, Antonio
name: Gobbi, Claudio
name: Bisecco, Alvino
name: Tedeschi, Gioacchino
name: Zecca, Chiara
name: Rocca, Maria A
name: Filippi, Massimo
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences

description: Supplemental material, sj-docx-2-msj-10.1177_13524585211020296 for Differential association of cortical, subcortical and spinal cord damage with multiple sclerosis disability milestones: A multiparametric MRI study by Milagros Hidalgo de la Cruz, Paola Valsasina, Alessandro Meani, Antonio Gallo, Claudio Gobbi, Alvino Bisecco, Gioacchino Tedeschi, Chiara Zecca, Maria A Rocca and Massimo Filippi in Multiple Sclerosis Journal
Additional file 6 of Soluble CX3CL1-expressing retinal pigment epithelium cells protect rod photoreceptors in a mouse model of retinitis pigmentosa
Creators: name: Jong, Eric D.
name: Hacibekiroglu, Sabiha
name: Guo, Lily
name: Sawula, Evan
name: Li, Biao
name: Li, Chengjin
name: Ho, Margaret T.
name: Shoichet, Molly S.
name: Wallace, Valerie A.
name: Nagy, Andras
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Additional file 6. Fig. S5 In vivo imaging of rd10 mice. Representative fundus and optical coherence tomography images (OCT) of A FS-Luc hRPE- or B FS-CX3-9 hRPE-treated rd10 retinas. PN, postnatal.
Acute disseminated encephalomyelitis (ADEM)
Creators: name: GARCIA GALARRAGA, GUILLERMO
Publisher: name: EURORAD
Year: 2018
Subjects: subject: Neuroradiology brain
subject: CT
subject: MR
subject: Diagnostic procedure
subject: Dilation
subject: Inflammation

description: Clinical History Image Findings Discussion Find Diagnosis Differential Diagnosis
description: male, 18 years
description: Clinical History: An 18 years-old man was admitted to the emergency department with five day-neurological symptoms consistent of motor dysfunction, right hand clumsiness and dysarthria. Previous days he had have cough and expectoration without fever.Both blood test a... Final Diagnosis: Acute disseminated encephalomyelitis (ADEM)
Additional file 1 of Soluble CX3CL1-expressing retinal pigment epithelium cells protect rod photoreceptors in a mouse model of retinitis pigmentosa
Creators: name: Jong, Eric D.
name: Hacibekiroglu, Sabiha
name: Guo, Lily
name: Sawula, Evan
name: Li, Biao
name: Li, Chengjin
name: Ho, Margaret T.
name: Shoichet, Molly S.
name: Wallace, Valerie A.
name: Nagy, Andras
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Additional file 1. The list of PCR primers used and their corresponding sequences.
An effective policy mix for scaling up carbon farming (Summary)
Creators: name: Mal, Mathieu
Publisher: name: Zenodo
Year: 2025

description: Policy environments are complex, and with the Carbon Removals and Carbon Farming Regulation (CRCF), a new and different type of policy is added into the mix of policies that can influence agricultural land management. If the policy mix is to be conducive to the enhanced uptake of carbon farming practices that enhance carbon sequestration in biogenic carbon pools, special attention needs to be paid to the possible interactions, synergies, and tensions between the different policies and frameworks. This document reflects the presentations and discussions held on three separate occasions in January 2025 in the context of Focus Group 2.3 under the Credible project. The areas of focus during these sessions have been the Common Agricultural Policy (CAP), the Soil Monitoring Law (SML), the Nature Restoration Law, and the “CRCF business case” which considers elements from voluntary corporate action and the ongoing discussions around compliance instruments for climate change mitigation action in the agri-food value chain. The overarching question when discussing these policy areas was: what can the CRCF and these other policy elements learn from each other and how can they, maximising synergies, lead to a conducive policy environment for robust carbon farming at scale.
Forschung an humanen embryonalen Stammzellen in Deutschland
Creators: name: Wobus, Anna M.
name: Guhr, Anke
name: Löser, Peter
Publisher: name: Robert Koch-Institut, Stammzellen
Year: 2015
Subjects: subject: Deutschland
subject: Stammzellen
subject: Historie
subject: 610 Medizin

description: Die Katholische Kirche gehört zu den schärfsten Kritikern der Biowissenschaften. Sie erkennt die positiven Fortschritte an, bemängelt aber Grenzüberschreitungen, die aus ihrer Sicht dem Menschen letztlich nicht dienen. Vor allem die Forschung mit humanen embryonalen Stammzellen und die vorgeburtliche Diagnostik stoßen auf Ablehnung. Viele Biowissenschaftler und Mediziner befürworten die Stammzellforschung und die vorgeburtliche Diagnostik. Die Beiträger analysieren dieses Spannungsverhältnis und fragen, wie es gelingen kann, die Gegensätze zu entschärfen.
Antiretroviral Therapy and Reasons for Not Taking It among Men Having Sex with Men (MSM)—Results from the European MSM Internet Survey (EMIS)
Creators: name: Marcus, Ulrich
name: Hickson, Ford
name: Weatherburn, Peter
name: Furegato, Martina
name: Breveglieri, Michele
name: Berg, Rigmor C.
name: Schmidt, Axel J.
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2015
Subjects: subject: Highly Active
subject: Humans
subject: Male
subject: Internet
subject: Adult
subject: Europe/epidemiology
subject: HIV Infections/drug therapy
subject: Regression Analysis
subject: Health Surveys
subject: Multivariate Analysis
subject: Antiretroviral Therapy
subject: Delivery of Health Care
subject: Demography
subject: FOS: Sociology
subject: Homosexuality Male/psychology
subject: Principal Component Analysis
subject: Treatment Refusal/statistics & numerical data
subject: Withholding Treatment
subject: 610 Medizin

description: Background: The preventive effects of antiretroviral treatment (ART) on onward transmission of HIV are a major reason for broadening eligibility for ART. In the WHO European Region, surveillance reveals substantial differences in access to ART across regions and sub-populations. We analysed self-reported data on ART and reasons for not taking ART from EMIS, a large Pan-European Internet survey among men-who-have-sex-with-men (MSM). Methods: Respondents from 38 European countries reported their last HIV test result and, if diagnosed with HIV, their treatment status, and reasons for not taking or having stopped ART from a 7 item multiple choice list and/ or answered an open-ended question to give other reasons. Responses were classified as fear of consequences, perceived lack of need, and ART inaccessibility based on factor analysis. Associations between not taking ART because of fear of consequences, and demographic, behavioural and contextual indicators were identified in a multivariable regression model. Results: 13,353 (7.7%) of 174,209 respondents had been diagnosed with HIV. Among them 3,391 (25.4%) had never received ART, and 278 (2.1%) had stopped taking ART. Perceived lack of need was by far the most common reason for not taking or stopping ART (mentioned by 3259 (88.8%) respondents), followed by fear of consequences (428 (11.7%)), and ART inaccessibility (86 (2.3%)). For all reasons, an East-West gradient could be seen, with larger proportions of men living in Central and Eastern Europe reporting reasons other than medical advice for not taking ART. A minority of men were reluctant to start ART independent of medical advice and this was associated with experiences of discrimination in health care systems. Conclusions: ART is widely available for MSM diagnosed with HIV across Europe. Not being on treatment is predominantly due to treatment not being recommended by their physician and/or not perceived to be needed by the respondent.
Additional file 2 of Soluble CX3CL1-expressing retinal pigment epithelium cells protect rod photoreceptors in a mouse model of retinitis pigmentosa
Creators: name: Jong, Eric D.
name: Hacibekiroglu, Sabiha
name: Guo, Lily
name: Sawula, Evan
name: Li, Biao
name: Li, Chengjin
name: Ho, Margaret T.
name: Shoichet, Molly S.
name: Wallace, Valerie A.
name: Nagy, Andras
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Additional file 2. Fig. S1 Generation and characterization of sCX3CL1-expressing hESC. A Schematic of sCX3CL1 construct. B Plots representing the sort of top 4.72% mCherry-expressing FS hESC that were transfected with the sCX3CL1 piggyBac expression cassette. C Western blotting analysis against 8×-His tag of hESC conditioned media and respective global protein stain (n = 2–3). Glycine, G; Serine, S; FLAG, FLAG tag; Histidine, His.
Characteristics and practices of National Immunisation Technical Advisory Groups in Europe and potential for collaboration, April 2014
Creators: name: Takla, Anja
name: Wichmann, Ole
name: Carrillo-Santisteve, P.
name: Cotter, S.
name: Lévy-Bruhl, D.
name: Paradowska-Stankiewicz, I.
name: Valentiner-Branth, P.
name: D’Ancona, F.
name: Group, VENICE III NITAG Survey
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2015
Subjects: subject: Humans
subject: Europe
subject: Health Surveys
subject: European Union
subject: Cooperative Behavior
subject: Surveys and Questionnaires
subject: Advisory Committees
subject: Health Planning Technical Assistance
subject: Immunization
subject: National Health Programs/organization & administration
subject: 610 Medizin

description: In many countries, national vaccination recommendations are developed by independent expert committees, so-called national immunisation technical advisory groups (NITAG). Since the evaluation of vaccines is complex and resource-demanding, collaboration between NITAGs that evaluate the same vaccines could be beneficial. We conducted a cross-sectional survey among 30 European countries in February 2014, to explore basic characteristics and current practices of European NITAGs and identify potential modes and barriers for collaboration. Of 28 responding countries, 26 reported to have a NITAG or an equivalent expert group. Of these, 20 apply a systematic approach in the vaccine decision-making process, e.g. by considering criteria such as country-specific disease epidemiology, vaccine efficacy/effectiveness/safety, health economics, programme implementation/logistics or country-specific values/preferences. However, applied frameworks and extent of evidence review differ widely. The use of systematic reviews is required for 15 of 26 NITAGs, while results from transmission modelling and health economic evaluations are routinely considered by 18 and 20 of 26 NITAGs, respectively. Twenty-five countries saw potential for NITAG-collaboration, but most often named structural concerns, e.g. different NITAG structures or countries’ healthcare systems. Our survey gathered information that can serve as an inventory on European NITAGs, allowing further exploration of options and structures for NITAG collaboration.
sj-pdf-1-cjb-10.1177_00938548211024706 – Supplemental material for “The Light at the End of the Tunnel Has Been Permanently Shut Off”: Work-Role Overload Among U.S. Police
Creators: name: Hofer, Meret S.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: 160299 Criminology not elsewhere classified
subject: FOS: Law
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, sj-pdf-1-cjb-10.1177_00938548211024706 for “The Light at the End of the Tunnel Has Been Permanently Shut Off”: Work-Role Overload Among U.S. Police by Meret S. Hofer in Criminal Justice and Behavior