cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Gromilus thoracicus
Creators: name: Morrone, Juan J.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Gromilus
Gromilus thoracicus

description: Gromilus thoracicus (Broun, 1893)
 Clypeorhynchus thoracicus Broun, 1893a: 1211 (type locality: New Zealand: Clevedon, southern Wairoa; type material: H: BMNH).
 Gromilus thoracicus; Kuschel, 1964: 459.
 Immature stages. Larva (May, 1993).
 Host plants. Blechnum capense (L.) Schlecht. (Blechnaceae), Polystichum sp. (Dryopteridaceae), and Pteris sp. (Pteridaceae) (May, 1977, 1993; Kuschel, 1990).
 Distribution. New Zealand (Schenkling and Marshall, 1929; Kuschel, 1990).
description: Published as part of Morrone, Juan J., 2011, Annotated checklist of the tribe Listroderini (Coleoptera: Curculionidae: Cyclominae) 3119, pp. 1-68 in Zootaxa 3119 (1) on page 25, DOI: 10.11646/zootaxa.3119.1.1, http://zenodo.org/record/5246257
A Search for Variability in the Active T dwarf 2MASS 1237+6526
Creators: name: Burgasser, Adam J.
name: Liebert, James
name: Kirkpatrick, J. Davy
name: Gizis, John E.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present spectroscopic and imaging observations of the active T dwarf 2MASS 1237+6526, intended to investigate the emission mechanism of this cool brown dwarf. The H$α$ emission line first detected in 1999 July appears to be persistent over 1.6 years, with no significant variation from $\log_{10}(L_{Hα}$/L$_{bol}$) = $-$4.3, ruling out flaring as a possible source. The relatively high level of emission in this object appears to be unique amongst observed late-L and T dwarfs. One of our spectra shows an apparent velocity shift in the H$α$ line, which could be indicative of an accretion hot spot in orbit around the brown dwarf; further confirmation of this shift is required. J-band monitoring observations fail to detect any significant variability (e.g., eclipsing events) at the $\pm$0.025 mag level over periods of up to 2.5 hours, and there appears to be no statistical evidence of variability for periods of up to 14 hours. These limits constrain the mass of a hypothetical interacting secondary to M$_2$ $\lesssim$ 20 M$_{Jup}$ for inclinations $i$ $\gtrsim$ 60$\degr$. While our observations do not explicitly rule out the binary hypothesis for this object, it does suggest that other mechanisms, such as youthful accretion, may be responsible.
description: 21 pages, 9 figures, accepted to AJ May 2002
Figures S1 - S13 from Transcriptional analysis of insect extreme freeze tolerance
Creators: name: Marteaux, Lauren E. Des
name: Hůla, Petr
name: Koštál, Vladimír
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences

description: Supplementary figures S1-S13 which are indicated in the main text
Self-similar solutions for finite size advection-dominated accretion flows
Creators: name: Kumar, Rajiv
name: Gu, Wei-Min
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We investigated effects on flow variables of transonic advection-dominated accretion flows (ADAFs) for different outer boundary locations (BLs) with a changing energy constant ($E$) of the flow. We used the ADAF solutions and investigated a general power index rule of a radial bulk velocity $(\vr\propto r^{-p})$ with different BLs, but the power index with radius for a rotation velocity and sound speed is unchanged. Here, $p\geq0.5$ is a power index. This power rule gives two types of self-similar solutions; first, when $p=0.5$ gives a self-similar solution of a first kind and exists for infinite length, which has already been discovered for the ADAFs by Narayan \& Yi, and second, when $p>0.5$ gives a self-similar solution of a second kind and exists for finite length, which corresponds to our new solutions for the ADAFs. By using this index rule in fluid equations, we found that the Mach number ($M$) and advection factor ($\fadv$) vary with the radius when $p>0.5$. The local energies of the ADAFs and the Keplerian disk are matched very well at the BLs. So, this theoretical study is supporting a two-zone configuration theory of the accretion disk, and we also discussed other possible hybrid disk geometries. The present study can have two main implications with a variation of the $p$; first, one that can help with the understanding of outflows and non-thermal spectrum variations in black hole candidates, and second, one that can help with solving partial differential equations for any sized advective disk.
description: 14 pages, 5 figures, Accepted for publication in ApJ
Gromilus variegatus
Creators: name: Morrone, Juan J.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Gromilus
Gromilus variegatus

description: Gromilus variegatus (Broun, 1893)
 Dacnophylla variegata Broun, 1893b: 301 (type locality: New Zealand: Mount Piroungia; type material: S: 5 BMNH).
 Gromilus variegatus; Kuschel, 1964: 459.
 Distribution. New Zealand (Schenkling and Marshall, 1929).
description: Published as part of Morrone, Juan J., 2011, Annotated checklist of the tribe Listroderini (Coleoptera: Curculionidae: Cyclominae) 3119, pp. 1-68 in Zootaxa 3119 (1) on page 25, DOI: 10.11646/zootaxa.3119.1.1, http://zenodo.org/record/5246257
Mechanics of nematic membranes: Euler-Lagrange equations, Noether charges, stress, torque and boundary conditions of the surface Frank nematic field
Creators: name: Santiago, J. A.
name: Monroy, F.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: The mechanics of a flexible membrane decorated with a nematic liquid-crystal texture is considered in a variational framework. The variations on the splay, twist and the bend energy of the nematics are obtained from the local deformations leading to changes in the shape membrane. The Euler-Lagrange derivatives and the Noether charges are identified from the variational equations. The nematic stress tensor is obtained as a consequence of translational invariance. Likewise, the rotational invariance implies the torque nematic tensor. The corresponding boundary conditions are obtained for free edges in the open-membrane configuration. These results constitute the basis of a generalized theory of elasticity for anisotropic nematic membranes. Some relevant consequences of the presence of nematic ordering are visualized at revolution surfaces with axial symmetry.
description: New version to appear in Journal of Phys. A
Additional file 3 of Optimization of tetramycin production in Streptomyces ahygroscopicus S91
Creators: name: Chen, Guang
name: Mengqiu Wang
name: Xianpu Ni
name: Huanzhang Xia
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 3: Figure S3. Inactivation of nysB in S.ahygroscopicus S91. a. Construction of the recombinant plamid pDNB; b. Double crossover validation of the recombinant strain S91-ΔNB; c.Verification of sequencing in the recombinant strain S91-ΔNB.
Gemini North adaptive optics system performance simulations
Creators: name: Jackson, Kate
name: Veran, Jean-Pierre
name: Van Kooten, Maaike
Publisher: name: Proceedings of AO4ELT7 conference 2023 - Editors: Thierry Fusco and Benoit Neichel
Year: 2023
Subjects: SYSTEM MODELLING
GEMINI NORTH
OOMAO

description: The Gemini North Adaptive Optics (GNAO) system will replace the current AO system on the Gemini North
telescope. GNAO will have a ground-conjugated deformable mirror (DM) and use an asterism of 4 sodium Laser
Guide Stars (LGSs) which can be configured in both narrow and wide field modes. As part of one of the Adaptive
Optics Bench (AOB) Phase A design study teams, NRC-HAA has used The Object Oriented Matlab Adaptive
Optics (OOMAO)[3] simulation tool to model the performance of the GNAO system. A large parameter space
has been explored, including the effects of wavefront sensor (WFS) and DM order, LGS asterism radius, and
performance as a function of telescope zenith angle. Sky coverage as a function of tip/tilt performance was
estimated using TIPTOP[5]. This work has been used to produce the expected error budget of the proposed
AOB design.
Additional file 1 of Enhancing patient and public contribution in health outcome selection during clinical guideline development: an ethnographic study
Creators: name: Biggane, Alice M.
name: Young, Bridget
name: Williamson, Paula R.
name: Whittingham, Erin
name: Cooper, Jessie
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1.
GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation
Creators: name: Terao, Chikashi
name: Momozawa, Yukihide
name: Ishigaki, Kazuyoshi
name: Kawakami, Eiryo
name: Akiyama, Masato
name: Loh, Po-Ru
name: Genovese, Giulio
name: Sugishita, Hiroki
name: Ohta, Tazro
name: Hirata, Makoto
name: Perry, John R. B.
name: Matsuda, Koichi
name: Murakami, Yoshinori
name: Kubo, Michiaki
name: Kamatani, Yoichiro
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Article
/631/208/2489/1381/1286
/631/208/205/2138
/631/443
/631/443/7
/45
/45/43
article

description: Abstract: Mosaic loss of chromosome Y (mLOY) is frequently observed in the leukocytes of ageing men. However, the genetic architecture and biological mechanisms underlying mLOY are not fully understood. In a cohort of 95,380 Japanese men, we identify 50 independent genetic markers in 46 loci associated with mLOY at a genome-wide significant level, 35 of which are unreported. Lead markers overlap enhancer marks in hematopoietic stem cells (HSCs, P ≤ 1.0 × 10−6). mLOY genome-wide association study signals exhibit polygenic architecture and demonstrate strong heritability enrichment in regions surrounding genes specifically expressed in multipotent progenitor (MPP) cells and HSCs (P ≤ 3.5 × 10−6). ChIP-seq data demonstrate that binding sites of FLI1, a fate-determining factor promoting HSC differentiation into platelets rather than red blood cells (RBCs), show a strong heritability enrichment (P = 1.5 × 10−6). Consistent with these findings, platelet and RBC counts are positively and negatively associated with mLOY, respectively. Collectively, our observations improve our understanding of the mechanisms underlying mLOY.
Going beyond copper: wafer-scale synthesis of graphene on sapphire
Creators: name: Mishra, N.
name: Forti, S.
name: Fabbri, F.
name: Martini, L.
name: McAleese, C.
name: Conran, B.
name: Whelan, P. R.
name: Shivayogimath, A.
name: Buß, L.
name: Falta, J.
name: Aliaj, I.
name: Roddaro, S.
name: Flege, J. I.
name: Bøggild, P.
name: Teo, K. B. K.
name: Coletti, C.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Applied Physics (physics.app-ph)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The adoption of graphene in electronics, optoelectronics and photonics is hindered by the difficulty in obtaining high quality material on technologically-relevant substrates, over wafer-scale sizes and with metal contamination levels compatible with industrial requirements. To date, the direct growth of graphene on insulating substrates has proved to be challenging, usually requiring metal-catalysts or yielding defective graphene. In this work, we demonstrate a metal-free approach implemented in commercially available reactors to obtain high-quality monolayer graphene on c-plane sapphire substrates via chemical vapour deposition (CVD). We identify via low energy electron diffraction (LEED), low energy electron microscopy (LEEM) and scanning tunneling microscopy (STM) measurements the Al-rich reconstruction root31R9 of sapphire to be crucial for obtaining epitaxial graphene. Raman spectroscopy and electrical transport measurements reveal high-quality graphene with mobilities consistently above 2000 cm2/Vs. We scale up the process to 4-inch and 6-inch wafer sizes and demonstrate that metal contamination levels are within the limits for back-end-of-line (BEOL) integration. The growth process introduced here establishes a method for the synthesis of wafer-scale graphene films on a technologically viable basis.
description: 15 main text pages, 4 main text figures, 13 supplementary information pages, 12 supplementary figures, 3 supplementary tables
A nonterminating 8-phi-7 summation for the root system C_r
Creators: name: Schlosser, Michael J.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: Quantum Algebra (math.QA)
subject: FOS: Mathematics
subject: 33D67 (Primary) 05A30, 33D05 (Secondary)

description: Using multiple q-integrals and a determinant evaluation, we establish a nonterminating 8-phi-7 summation for the root system C_r. We also give some important specializations explicitly.
description: 12 pages
Gromilus veneris
Creators: name: Morrone, Juan J.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Gromilus
Gromilus veneris

description: Gromilus veneris (Kirsch, 1877)
 Steriphus veneris Kirsch, 1877: 168 (type locality: New Zealand: Auckland Islands, south coast of Rose Island; type material: L: SMTD).
 Stilbodiscus setarius Broun, 1909: 118 (type locality: New Zealand: Campbell Island; type material: H: BMNH).
 Gromilus veneris veneris; Kuschel, 1964: 464.
 Gromilus veneris setarius; Kuschel, 1964: 466, syn. nov.
 Immature stages. Larva (May, 1971).
 Host plants. Anisotome latifolia Hook. f. (Apiaceae), Bulbinella sp. (Liliaceae), Cotula plumosa Hook. f. and Pleurophyllum criniferum Hook. f. (Asteraceae), and Poa litorosa Cheeseman (Poaceae) (Kuschel, 1964, 1971).
 Distribution. New Zealand: Auckland and Campbell Islands (Kuschel, 1964, 1971).
description: Published as part of Morrone, Juan J., 2011, Annotated checklist of the tribe Listroderini (Coleoptera: Curculionidae: Cyclominae) 3119, pp. 1-68 in Zootaxa 3119 (1) on page 25, DOI: 10.11646/zootaxa.3119.1.1, http://zenodo.org/record/5246257
Coronal--Temporal Correlations in GX339-4: Hysteresis, Possible Reflection Changes, and Implications for ADAFs
Creators: name: Nowak, Michael A.
name: Wilms, Joern
name: Dove, James B.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present spectral fits and timing analysis of Rossi X-ray Timing Explorer observations of GX339-4. These observations were carried out over a span of more than two years and encompassed both the soft/high and hard/low states. Hysteresis in the soft state/hard state transition is observed. The hard state exhibits a possible anti-correlation between coronal compactness (i.e., spectral hardness) and the covering fraction of cold, reflecting material. The correlation between `reflection fraction' and soft X-ray flux, however, appears to be more universal. Furthermore, low flux, hard state observations - taken over a decline into quiescence- show that the Fe line, independent of `reflection fraction', remains broad and at a roughly constant equivalent width, counter to expectations from ADAF models. All power spectral densities (PSD) of the hard state X-ray lightcurves are describable as the sum of just a few broad, quasi-periodic features with frequencies that roughly scale as coronal compactness to the -3/2 power. Similar to observations of Cyg X-1, time lags between soft and hard variability anti-correlate with coronal compactness. A stronger correlation is seen between the time lags and the `reflection fraction'.
description: 29 Pages, 17 Figures, 6 Tables. Accepted for Publication in MNRAS. (Abstract Abridged)
Percolation of strings and the first RHIC data on multiplicity and tranverse momentum distributions
Creators: name: Braun, M. A.
name: del Moral, F.
name: Pajares, C.
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The dependence of the multiplicity on the number of collisions and the transverse momentum distribution for central and peripheral Au-Au collisions are studied in the model of percolation of strings relative to the experimental conditions at RHIC. The comparison with the first RHIC data shows a good agreement.
description: RevTeX, 11 pages, 4 eps figures included using epsfig
Noncommutative 3D harmonic oscillator
Creators: name: Smailagic, A.
name: Spallucci, E.
Publisher: name: arXiv
Year: 2002
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We find transformation matrices allowing to express non-commutative three dimensional harmonic oscillator in terms of an isotropic commutative oscillator, following ``philosophy of simplicity'' approach. Non-commutative parameters have physical interpretation in terms of an external magnetic field. Furthermore, we show that for a particular choice of noncommutative parameters there is an equivalent anisotropic representation, whose transformation matrices are far more complicated. We indicate a way to obtain the more complex solutions from the simple ones.
description: 7pages, LateX 2e, no figures; in print on J.Phys.A
Additional file 1 of Is double-strut fibula ankle arthrodesis a reliable reconstruction for bone defect after distal tibia tumor resection?—a finite element study based on promising clinical outcomes
Creators: name: Zhao, Zhiqing
name: Yan, Taiqiang
name: Guo, Wei
name: Yang, Rongli
name: Tang, Xiaodong
Publisher: name: figshare
Year: 2021
Subjects: Medicine
Cell Biology
Biotechnology
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Mathematical Sciences not elsewhere classified

description: Additional file 1: Figure 1. The pictures indicate VMS of implant in three groups when a vertical compressive force of 600 N corresponding the body weight of a person weighing 60 kg was applied to the tibial plateau. Figure 2. The pictures indicate VMS of fibular graft in three groups.
Identification of potential inhibitors targeting Ebola virus VP35 protein: a computational strategy
Creators: name: Chen, Yan-kun
name: Gahtani, Reem M.
name: Al Shahrani, Mesfer
name: Hani, Umme
name: Alshabrmi, Fahad M.
name: Alam, Sarfaraz
name: Almohaimeed, Hailah M.
name: Basabrain, Ammar A.
name: Shahab, Muhammad
name: Xie, Meng-zhou
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Ebola virus (EBOV) poses a severe threat as a highly infectious pathogen, causing devastating hemorrhagic fever in both humans and animals. The EBOV virus VP35 protein plays a crucial role in viral replication and exhibits the ability to suppress the host interferon cascade, leading to immune system depletion. As a potential drug target, VP35 protein inhibition holds promise for combating EBOV. To discover new drug candidates, we employed a computer-aided drug design approach, focusing on compounds capable of inhibiting VP35 protein replication. In this connection, a pharmacophore model was generated using molecular interactions between the VP35 protein and its inhibitor. ZINC and Cambridge database were screened using validated pharmacophore model. Further the compounds were filtered based on Lipinski’s rule of five and subjected to MD simulation and relative binding free energy calculation. Six compounds manifest a significant docking score and strong binding interaction towards VP35 protein. MD simulations further confirmed the remarkable stability of these six complexes. Relative binding free energy calculations also showed significant ΔG value in the range of −132.3 and −49.3 kcal/mol. This study paves the way for further optimization of these compounds as potential inhibitors of VP35, facilitating subsequent experimental in vitro studies.
Additional file 4 of Optimization of tetramycin production in Streptomyces ahygroscopicus S91
Creators: name: Chen, Guang
name: Mengqiu Wang
name: Xianpu Ni
name: Huanzhang Xia
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 4: Figure S4. Inactivation of ttmD in S.ahygroscopicus S91-ΔNB. a. Construction of the recombinant plasmid pDTD; b. Double crossover validation of the recombinant strain S91-ΔNBΔTD; c. Verification of sequencing in the recombinant strain S91-ΔNBΔTD.
Additional file 2 of Comparing rates of mycobacterial clearance in sputum smear-negative and smear-positive adults living with HIV
Creators: name: Machowski, Edith E.
name: Matebogo Letutu
name: Limakatso Lebina
name: Ziyaad Waja
name: Reginah Msandiwa
name: Milovanovic, Minja
name: Gordhan, Bhavna G.
name: Otwombe, Kennedy
name: Friedrich, Sven O.
name: Chaisson, Richard
name: Diacon, Andreas H.
name: Bavesh Kana
name: Martinson, Neil
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences
subject: Computational Biology

description: Additional file 2: Supplementary Table S2.
Gunodes Brinck 1948
Creators: name: Morrone, Juan J.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Gunodes

description: Gunodes Brinck, 1948
 Gunodes Brinck, 1948: 55 (type species: G. major Brinck, 1948, by original designation).
description: Published as part of Morrone, Juan J., 2011, Annotated checklist of the tribe Listroderini (Coleoptera: Curculionidae: Cyclominae) 3119, pp. 1-68 in Zootaxa 3119 (1) on page 25, DOI: 10.11646/zootaxa.3119.1.1, http://zenodo.org/record/5246257
Integrability approach to Feher-Nemethi-Rimanyi-Guo-Sun type identities for factorial Grothendieck polynomials
Creators: name: Motegi, Kohei
Publisher: name: arXiv
Year: 2019
Subjects: subject: Combinatorics (math.CO)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: Recently, Guo and Sun derived an identity for factorial Grothendieck polynomials which is a generalization of the one for Schur polynomials by Fehér, Némethi and Rimányi. We analyze the identity from the point of view of quantum integrability, based on the correspondence between the wavefunctions of a five-vertex model and the Grothendieck polynomials. We give another proof using the quantum inverse scattering method. We also apply the same idea and technique to derive an identity for factorial Grothendieck polynomials for rectangular Young diagrams. Combining with the Guo-Sun identity, we get a duality formula. We also discuss a $q$-deformation of the Guo-Sun identity.
description: 21 pages
Revealing curcumin therapeutic targets on SRC, PPARG, MAPK8 and HSP90 as liver cirrhosis therapy based on comprehensive bioinformatic study
Creators: name: Al Khairy Siregar, Khalish Arsy
name: Syaifie, Putri Hawa
name: Jauhar, Muhammad Miftah
name: Arda, Adzani Gaisani
name: Rochman, Nurul Taufiqu
name: Kustiawan, Paula Mariana
name: Mardliyati, Etik
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Computational Biology

description: Cirrhosis naturally progresses through three stages: compensated, decompensated, and late decompensated, which carry an elevated risk of death. Although curcumin’s anti-cirrhosis effects have been studied, underlying mechanism in preventing cirrhosis progression and the correlation between curcumin’s action with upregulated genes remains insufficiently explored. In this study, we employed network pharmacology approach to construct a drug-target-disease network through bioinformatics and validate the findings with molecular docking and dynamic simulation. The curcumin-targeted liver cirrhosis network encompassed 54 nodes with 282 edges in protein-protein interactions (PPI) network. By utilizing network centrality analysis, we identified eight crucial genes. KEGG enrichment pathway revealed that these crucial genes are involved in pathway of cancer, endocrine resistance, estrogen signaling, chemical carcinogenesis-receptor activation, lipid metabolism, and atherosclerosis. Notably, these eight genes predominantly participate in cancer-related pathways. Further investigation revealed upregulation of four genes and downregulation of four others in hepatocellular carcinoma patients. These upregulated genes—MAPK8, SRC, PPARG, and HSP90AA1—strongly correlated with reduced survival probability in liver hepatocellular carcinoma patients with survival times approximately under 4000 days (∼11 years). Molecular docking and molecular dynamic results exhibited curcumin’s superior binding affinities and stability compared to native ligands of MAPK8, SRC, PPARG, and HSP90AA1 within 50 ns simulations. Moreover, MM-GBSA analysis showed stronger binding energy of curcumin to MAPK8, SRC, and HSP90AA1 than native ligand. In conclusion, this study provides valuable insights into curcumin’s potential mechanisms in preventing liver cirrhosis progression, specifically in HCC. These findings offer a theoretical basis for further pharmacological research into anti-HCC effect of curcumin.
Lower bounds on the $L_p$ discrepancy of digital NUT sequences
Creators: name: Kritzinger, Ralph
name: Pillichshammer, Friedrich
Publisher: name: arXiv
Year: 2019
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11K38, 11K31

description: We study the $L_p$ discrepancy of digital NUT sequences which are an important sub-class of digital $(0,1)$-sequences in the sense of Niederreiter. The main result is a lower bound for certain sub-classes of digital NUT sequences.
description: 13 pages
Effect of fluorination on the partitioning of alcohols
Creators: name: Barhaghi, Mohammad Soroush
name: Luyet, Chloe
name: Potoff, Jeffrey J.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: In order to understand the role of fluorination on the interactions and partitioning of alcohols in aqueous and organic environments, isobaric-isothermal ensemble Monte Carlo simulations are used to determine environmental predictors, such as free energies of hydration and solvation in 1-octanol and n-hexadecane. Calculations are performed with the united-atom Transferable Potentials for Phase Equilibria (TraPPE) force field and compared against available experimental data. TraPPE was found to provide reliable qualitative predictions of trends with respect to the effect of fluorination on partitioning. Investigation of the local solvation environment around the hydroxyl group reveals that fluorination of carbons closest to the hydroxyl group has the greatest effect on solvation free energies for alcohols in water, 1-octanol and n-hexadecane.
Additional file 1 of IL-4 modified expanded polytetrafluoroethylene (e-PTFE) surgical patch promotes angiogenesis in transplanted flap and inhibits inflammatory response
Creators: name: Song, Peng
name: Liu, Yizheng
name: Du, Chenfei
name: Lei, Zhen
name: Ai, Jinwei
name: Li, Guanghui
name: Jing, Kai
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology

description: Additional file: The images of original blots.
Self-competence increases the willingness to pay for social influence
Creators: name: Hertz, Uri
name: Tyropoulou, Evangelia
name: Traberg, Cecilie
name: Bahrami, Bahador
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Article
/631/477
/631/477/2811
/631/378/2649
/631/378/3919
/631/378/2645
article

description: Abstract: Theoretical works in social psychology and neuroscientific evidence have proposed that social rewards have intrinsic value, suggesting that people place a high premium on the ability to influence others. To test this hypothesis, we asked whether, and under what conditions, people are willing to forgo monetary reward for the sake of influencing others’ decisions. In four experiments, online and lab-based participants competed with a rival for influence over a client. The majority of participants sacrificed some of their financial reward to increase their chance of being selected over their rival within the experiment. Willingness to pay was affected by the participant’s current level of influence and performance, as participants were most likely to pay to promote their competence after having given good advice that had been ignored by the client using a situation where monetary incentives fail to explain human motivations, our experiments highlight the intrinsic value of social influence.
In-medium chiral perturbation theory beyond the mean-field approximation
Creators: name: Meißner, Ulf-G.
name: Oller, José A.
name: Wirzba, Andreas
Publisher: name: arXiv
Year: 2001
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: An explicit expression of the generating functional of two-flavor low-energy QCD with external sources in the presence of non-vanishing nucleon densities has been derived recently [1]. Within this approach we derive power counting rules for the calculation of in-medium pion properties. We develop the so-called standard rules for residual nucleon energies of the order of the pion mass and a modified scheme (non-standard counting) for vanishing residual nucleon energies. We also establish the different scales for the range of applicability of this perturbative expansion, which are \sqrt{6}πf_π\simeq 0.7 GeV for the standard and 6π^2 f_π^2/2m_N\simeq 0.27 GeV for non-standard counting, respectively. We have performed a systematic analysis of n-point in-medium Green functions up to and including next-to-leading order when the standard rules apply. These include the in-medium contributions to quark condensates, pion propagators, pion masses and couplings of the axial-vector, vector and pseudoscalar currents to pions. In particular, we find a mass shift for negatively charged pions in heavy nuclei that agrees with recent determinations from deeply bound pionic Pb-207. We have also established the absence of in-medium renormalization in the π^0 \to γγdecay amplitude up to the same order. The study of ππscattering requires the use of the non-standard counting and the calculation is done at leading order. Even at that order we establish new contributions not considered so far. We also point towards further possible improvements of this scheme and touch upon its relation to more conventional many-body approaches.
description: 40 pages, 12 figures, version to appear in Ann. Phys
The Luxembourg Agreement Reform of the CAP: an Analysis Using the AG-MEMOD Composite Model
Creators: name: Chantreuil, Frédéric
name: Levert, Fabrice
name: Hanrahan, Kevin
name: Chantreuil, Frédéric
name: Levert, Fabrice
name: Hanrahan, Kevin
Publisher: name: Unknown
Year: 2005
Subjects: subject: Agricultural and Food Policy
subject: Research Methods/ Statistical Methods
subject: Partial Equilibrium Modelling
subject: EU CAP Reform
subject: Decoupling
subject: Agriculture

description: In this paper we present the results for EU-15 of a simulation of the Luxembourg CAP reform based on the AG-MEMOD composite model. This dynamic partial equilibrium econometric multi products model comprises of national country level sub-models that are combined to be linked and solved in prices generating projections for each country, and the entire EU, for each year to a 10-year horizon. Under the Luxembourg reform scenario simulated direct payments in the grains and oilseeds, cattle and beef, and sheep commodity market organisations are fully decoupled. Intervention price reductions for butter agreed as part of the reform are also considered. The impact of the Luxembourg Agreement reform scenario is measured against a Baseline of a continuation of Agenda 2000 agricultural policy. The impact of the Luxembourg Agreement reform scenario is measured against a Baseline of a continuation of Agenda 2000 EU agricultural policy.
RF current condensation in magnetic islands and associated hysteresis phenomena
Creators: name: Rodriguez, Eduardo
name: Reiman, Allan H.
name: Fisch, Nathaniel J.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: The nonlinear RF current condensation effect suggests that magnetic islands might be well controlled with broader deposition profiles than previously thought possible. To assess this possibility, a simplified energy deposition model in a symmetrised 1D slab geometry is constructed. By limiting the RF wave power that can be absorbed through damping, this model describes also the predicted hysteresis phenomena. Compared to the linear model, the nonlinear effects lead to larger temperature variations, narrower deposition widths, and more robust island stabilisation. Although, in certain regimes, the island centre can be disadvantageously shaded because of the nonlinear effects, in general, the RF condensation effect can take place, with current preferentially generated, advantageously, close to the island centre.
Wounded nucleon, quark and quark-diquark emission functions versus experimental results from RHIC
Creators: name: Barej, Michał
name: Bzdak, Adam
name: Gutowski, Paweł
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Experiment (nucl-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Using the wounded nucleon, quark, and quark-diquark models, we extract the wounded source emission functions from the PHOBOS data for d+Au collisions at $\sqrt{s_{_{NN}}}=200$ GeV. We apply these models to compute charged particle multiplicity distributions as functions of pseudorapidity for p+p, p+Al, p+Au, d+Au, $^3$He+Au, Cu+Cu, Cu+Au, Au+Au, and U+U collisions at the same energy and compare them with experimental data from the PHOBOS and PHENIX collaborations. In symmetric collisions of heavy nuclei, the obtained distributions differ among the tested models. On the other hand, in asymmetric collisions, all three models give essentially the same distributions. The wounded quark-diquark and quark models are in reasonable agreement with data for all the investigated systems.
description: 14 pages, 11 figures
Additional file 1 of Intersecting sex-related inequalities in self-reported testing for and prevalence of Non-Communicable Disease (NCD) risk factors in Kerala
Creators: name: Negi, Jyotsna
name: Sankar D, Hari
name: Nair, Arun B.
name: Nambiar, Devaki
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 1. Descriptive analysis and simple measures of inequality for men and women in each of the four selected indicators.
Additional file 5 of Optimization of tetramycin production in Streptomyces ahygroscopicus S91
Creators: name: Chen, Guang
name: Mengqiu Wang
name: Xianpu Ni
name: Huanzhang Xia
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 5: Figure S5. Cloning and overexpression of ttmRIV. a. Construction of the recombinant plamid pETRIV; b. PCR analysis of the recombinant strain S91-ΔNBΔTD::TRIV, M. DL2000 (2.0k, 1.0k, 0.75k, 0.5k, 0.25k, 0.1k), 1. S91-ΔNBΔTD::pETRIV/PB-1& TRIV-R (1.1k), 2. S91-ΔNBΔTD/PB-1&TRIV-R, 3. S91-ΔNBΔTD::pSET152/PB-1&TRIV-R.
Forecast for FAST: from Galaxies Survey to Intensity Mapping
Creators: name: Hu, Wenkai
name: Wang, Xin
name: Wu, Fengquan
name: Wang, Yougang
name: Zhang, Pengjie
name: Chen, Xuelei
Publisher: name: arXiv
Year: 2019
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The Five-Hundred-Meter Aperture Spherical Radio Telescope(FAST) is the largest single-dish radio telescope in the world. In this paper, we make forecast on the FAST HI large scale structure survey by mock observations. We consider a drift scan survey with the L-band 19 beam receiver, which may be commensal with the pulsar search and Galactic HI survey. We also consider surveys at lower frequency, either using the current single feed wide band receiver, or a future multi-beam phased array feed (PAF) in the UHF band. We estimate the number density of detected HI galaxies and the measurement error in positions, the precision of the surveys are evaluated using both Fisher matrix and simulated observations. The measurement error in the HI galaxy power spectrum is estimated, and we find that the error is relatively large even at moderate redshifts, as the number of positively detected galaxies drops drastically with increasing redshift. However, good cosmological measurement could be obtained with the intensity mapping technique where the large scale HI distribution is measured without resolving individual galaxies. The figure of merit (FoM) for the dark energy equation of state with different observation times are estimated, we find that with the existing L-band multi-beam receiver, a good measurement of low redshift large scale structure can be obtained, which complements the existing optical surveys. With a PAF in the UHF band, the constraint can be much stronger, reaching the level of a dark energy task force (DETF) stage IV experiment.
description: 17 pages, 18 figures, fixed problems in references, version accepted by MNRAS
Additional file 2 of Intersecting sex-related inequalities in self-reported testing for and prevalence of Non-Communicable Disease (NCD) risk factors in Kerala
Creators: name: Negi, Jyotsna
name: Sankar D, Hari
name: Nair, Arun B.
name: Nambiar, Devaki
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 2. Definitions and Interpretations of the summary measures used to measure inequality in each of the four selected indicators.
Gunodes major Brinck 1948
Creators: name: Morrone, Juan J.
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Curculionidae
Gunodes
Gunodes major

description: Gunodes major Brinck, 1948
 Gunodes major Brinck, 1948: 56 (type locality: Tristan da Cunha-Gough islands: Nightingale, the Second Pond; type material: H: ZMUN).
 Distribution. Tristan da Cunha-Gough islands (Brinck, 1948).
description: Published as part of Morrone, Juan J., 2011, Annotated checklist of the tribe Listroderini (Coleoptera: Curculionidae: Cyclominae) 3119, pp. 1-68 in Zootaxa 3119 (1) on page 25, DOI: 10.11646/zootaxa.3119.1.1, http://zenodo.org/record/5246257
Molecular dynamics and DFT study on the structure and dynamics of N-terminal domain HIV-1 capsid inhibitors
Creators: name: Collins U. Ibeji
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology

description: HIV-1 infection is a major threat in the world and has drawn much attention. The emergence of drug-resistance to most of the HIV-1 inhibitors has led to the crucial call for new inhibitors that can interact with the amino terminal domain of HIV-1 CAPSID (CA) and disrupt viral replication. In this study, molecular dynamics simulation was performed on two class of 4,5-dihydro-1H-pyrrolo[3,4-c]pyrazol-6 one (pyrrolopyrazolone) HIV-1 inhibitors (BI-1 and BI-2) reported to inhibit early postentry stages of viral replication. The effect of N-methylation on the binding of BI-1 and BI-2 to N-terminal HIV-1 capsid of the enzyme was also studied and the structural features such as root mean square deviation (RMSD), root mean square fluctuation (RMSF), the radius of gyration (Rg) were analysed. Density functional theory (DFT) calculations using M06/6311++G(2d,2p) was employed to further investigate the nature of charge transfer of inhibitors based on the second-order perturbation theory. Results obtained showed that N-methylation enhanced the binding of BI-1 with MMPBSA binding energy of −6.2 kcal mol−1 compared to −4.2 kcal mol−1 of BI-1. N-methylation did not have a considerable effect on the binding energy of BI-2, but the MMPBSA binding energy (BI-2_N-methyl) is better, compared to BI-1 and its N-methylated analogue (BI-1_N-methyl). The MMPBSA energies were consistent with the experimental findings.
Pressure-induced electro-switching of polymer/nano-graphene composites
Creators: name: Kolonelou, Eirini
name: Papathanassiou, Anthony N.
name: Sakellis, Elias
Publisher: name: arXiv
Year: 2019
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The pressure and temperature dependency of the electrical conductivity of poly(vinyl alcohol)/poly(vinyl pyrrolidone) (1/1, w/w) and poly(vinyl alcohol) and composites with dispersed nano-graphene platelets were studied. Above the critical platelet fraction for electric charge percolation, the composites function as pressure-induced electro-switches. The conductor to insulator transition is optimally intense and stable. The electrical conductivity drops by two orders of magnitude at a critical pressure around 750 bars. The transition is stable over tenths of degrees above room temperature. The reduction of the conductivity upon pressure results from the competition between the pressure dependencies of the polarizability of the polymer matrix and the inter-platelet separation, respectively. Both contributions control the fluctuation induced tunneling of electrons through the polymer barrier separating adjusting conductive platelets. The role of the local electric field at the polymer-platelet interfaces by assisting tunneling is suppressed by the decrease of the polarizability upon pressure.
Detergent induced structural perturbations in peanut agglutinin: insights from spectroscopic and molecular dynamic simulation studies
Creators: name: Asthana, Shreyasi
name: Mohanty, Sonali
name: Kalra, Harshit
name: Karunanethy, Nandini
name: Kumar, Sujeet
name: Agrawal, Nikhil
name: Jha, Suman
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: The three dimensional structure of a protein is very important for its structure. Studies relating to protein structure have been numerous and the effect of denaturants on proteins can help understand the process of protein folding and misfolding. Detergents are important denaturants and play important roles in various fields. Here we explored the effect of sodium dodecyl sulphate (SDS) and cetyltrimethylammonium bromide (CTAB) on the structure of peanut agglutinin (PNA). The protein was purified from its natural source and impact of SDS and CTAB was studied by circular dichroism, intrinsic fluorescence, 8-anilino-1-napthalenesulfonic acid, molecular docking and molecular dynamics simulation. Pure peanut agglutinin showed a trough at 220 nm and positive ellipticity peak at 195 nm, specific for lectins. Results from the experimental and simulation studies suggest how oppositely charged detergents can interact differently and lead to varied structural perturbations in PNA. Both the surfactants induce all α protein-like circular dichroism in the protein, above its critical micelle concentrations, with significant change in accessible surface area that became more hydrophobic upon the treatment. Major interactions between the surfactants and protein, resulting in PNA conformational rearrangement, are electrostatic and van der Waals interactions. However, CTAB, a cationic surfactant, has similar effects as anionic surfactant (SDS) but at significantly very low concentration. Though the effects followed same pattern in both the surfactant treatment, i.e. above respective CMC, the surfactants were inducing all α protein-like conformation in PNA.
Not quite black holes at LIGO
Creators: name: Holdom, Bob
Publisher: name: arXiv
Year: 2019
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We provide more evidence of not quite black holes at LIGO. We update and streamline our previous search strategy and apply it to the ten black hole merger events and the one neutron star merger event. The strategy is aimed at the evenly spaced resonance spectrum expected from not quite black holes, given that at low frequencies the radial wave equation describes the modes of a stretched 1D cavity. We describe various indications of the self-consistency of the apparent signals across all events in the context of a simple theoretical model. The merger with the largest final mass, spin and redshift, GW170729, provides additional interesting support.
description: 20 pages, 16 figures, published version