cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Integrare l'alunno disabile in classe: attivare risorse poco riconosciute o dormienti, per perseguire concretamente l'obiettivo dell'integrazione scolastica dell'alunno disabile
Creators: name: Cicero, Luca
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2015
Subjects: disabilità
integrazione
autismo
autonomia
sostegno

description: Questo lavoro di tesi nasce da tre motivazioni. La prima trae origine dall'opportunità di accostare l'esperienza pratica professionale come educatore scolastico ad una riflessione teorica. La seconda trae origine dalla lettura del romanzo di Fulvio Ervas “Se ti abbraccio non aver paura” in cui si sottolinea l'importanza di creare una rete di amicizie che sostenga i ragazzi disabili in ambiti alternativi alla famiglia e alla scuola. La terza trae origine dall'attivazione del progetto educativo “gli In-visibili” presso la scuola secondaria di secondo grado, dove l’autore della tesi, collabora con uno studente con Disturbi dello Spettro Autistico. In esso l'attore principale non è il soggetto disabile ma i suoi compagni di classe in quanto gestori del processo di interazione con l'amico disabile. Lo scopo di questo lavoro di tesi è analizzare il ruolo dell'educatore che opera per il servizio di assistenza scolastica a Como, mettendolo in relazione con gli altri soggetti presenti in classe e affrontando la problematica dell'integrazione scolastica dell'alunno disabile all'interno del gruppo classe. Per far questo si analizza il rapporto che si instaura tra educatore, ragazzo disabile e gli altri soggetti presenti a scuola, cercando di capire come evitare isolamento ed esclusione. La Legge-quadro 104/92 per l'assistenza, l'integrazione sociale e i diritti delle persone handicappate comprende al suo interno anche i principi generali dell'integrazione scolastica e le linee guida per l'integrazione extrascolastica. In essa non viene definito uno statuto che dia all'educatore scolastico un quadro istituzionale, un ruolo, dei compiti e dei livelli d’intervento ben definiti ponendo dei confini certi al suo agire. Questa lacuna ha degli effetti negativi, come ad esempio, i conflitti di competenza tra educatori ed insegnanti. Semplificando, si potrebbe dire che l'insegnante di sostegno si occupa della didattica, mentre l'educatore scolastico di tutto ciò che riguarda le autonomie, la comunicazione, la relazione con i compagni e la socializzazione in generale. Per analizzare l'integrazione scolastica sarà necessario intendersi sul concetto d’integrazione, che in questo lavoro di tesi viene delineato come l'inserimento di un elemento nuovo in un'unità complessa per farlo interagire in maniera attiva. Questa visione considera la classe come un sistema e ciò aiuta l'educatore a comprendere se i processi d’interazione in essa presenti sono facilitatori o ostacoli all'integrazione dello studente disabile. Nelle conclusioni, in base alle riflessioni fatte, si osserverà con una lente panoramica la figura dell'educatore scolastico e dell'operatore sociale in generale, cercando di coglierne limiti, potenzialità e possibili sviluppi professionali futuri.
The structure, function, and pharmacology of MRGPRs
Creators: name: Cao C
name: Roth B.L
Publisher: name: Elsevier Ltd
Year: 2023

description: Mas-related G protein-coupled receptor (MRGPR) family members play important roles in the sensation of noxious stimuli and represent novel targets for the treatment of itch and pain. MRGPRs recognize a diversity of agonists and display complicated downstream signaling profiles, high sequence diversity across species, and many polymorphisms in humans. The recent structural advances on MRGPRs reveal unique structural features and diverse agonist recognition modes of this receptor family, which should facilitate the structure-based drug discovery at MRGPRs. In addition, the newly discovered ligands also provide valuable tools to explore the function and the therapeutic potential of MRGPRs. In this review, we discuss these progresses in our understanding of MRGPRs and highlight the challenges and potential opportunities for the future drug discovery at these receptors.
Dysschema porioni
Creators: name: Vincent, Benoît
name: Laguerre, Michel
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Erebidae
Dysschema
Dysschema porioni

description: Dysschema porioni (Gibeaux, 1982)
Pericopis porioni Gibeaux, 1982: 49.
TYPE LOCALITY. — Peru, [San Martin], Route Olmos à Moyobamba, Km 374.
TYPE SPECIMEN. — Holotype male (MNHN).
description: Published as part of Vincent, Benoît & Laguerre, Michel, 2014, Catalogue of the Neotropical Arctiini Leach, [1815] (except Ctenuchina Kirby, 1837 and Euchromiina Butler, 1876) (Insecta, Lepidoptera, Erebidae, Arctiinae), pp. 137-533 in Zoosystema 36 (2) on page 473, DOI: 10.5252/z2014n2a1, http://zenodo.org/record/5395344
The trials and tribulations of determining HbA1c targets for diabetes mellitus
Creators: name: Klein K.R
name: Buse J.B
Publisher: name: Nature Research
Year: 2020

description: Glycated haemoglobin (HbA1c) is considered the gold standard for predicting glycaemia-associated risks for the microvascular and macrovascular complications of diabetes mellitus over 5–10 years. The value of HbA1c in the care of patients with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) is unassailable, yet HbA1c targets remain contentious. Guidelines from diabetes care organizations recommend conflicting HbA1c targets — generally between 6.5% and 8%. However, all such organizations advocate for individualization of HbA1c targets, leaving both health-care providers and their patients confused about what HbA1c target is appropriate in an individual patient. In this Review, we outline the landmark T1DM and T2DM trials that informed the current guidelines, we discuss the evidence that drives individualized HbA1c targets, we examine the limitations of HbA1c, and we consider alternatives for monitoring glycaemic control. Ultimately, in synthesizing this literature, we argue for an HbA1c target of <7% for most individuals, but emphasize the importance of helping patients determine their own personal goals and determinants of quality of life that are independent of a particular glycaemic target. We also recognize that as newer technologies and anti-hyperglycaemic therapies emerge, glycaemic targets will continue to evolve.
Dysschema schadei
Creators: name: Vincent, Benoît
name: Laguerre, Michel
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Erebidae
Dysschema
Dysschema schadei

description: Dysschema schadei (Schaus, 1927)
Pericopis schadei Schaus, 1927b: 103.
TYPE LOCALITY. — Paraguay, [Guaira], Villarica.
TYPE SPECIMENS. — Undisclosed number of female syntypes (USNM; one syntype).
description: Published as part of Vincent, Benoît & Laguerre, Michel, 2014, Catalogue of the Neotropical Arctiini Leach, [1815] (except Ctenuchina Kirby, 1837 and Euchromiina Butler, 1876) (Insecta, Lepidoptera, Erebidae, Arctiinae), pp. 137-533 in Zoosystema 36 (2) on page 473, DOI: 10.5252/z2014n2a1, http://zenodo.org/record/5395344
Dysschema hilara subsp. hilara hilara (Weymer 1895
Creators: name: Vincent, Benoît
name: Laguerre, Michel
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Erebidae
Dysschema
Dysschema hilara
Dysschema hilara hilara (weymer, 1895)

description: Dysschema hilara hilara (Weymer, 1895)
Thebrone hilara Weymer, 1895: 325.
TYPE LOCALITY. — [Brazil], [Rio Grande do Sul].
TYPE SPECIMEN. — Holotype female (ZMHB).
description: Published as part of Vincent, Benoît & Laguerre, Michel, 2014, Catalogue of the Neotropical Arctiini Leach, [1815] (except Ctenuchina Kirby, 1837 and Euchromiina Butler, 1876) (Insecta, Lepidoptera, Erebidae, Arctiinae), pp. 137-533 in Zoosystema 36 (2) on page 473, DOI: 10.5252/z2014n2a1, http://zenodo.org/record/5395344
Assessment of Gold and Mercury Losses in an Artisanal Gold Mining Site in Nigeria and Its Implication on the Local Economy and the Environment
Creators: name: Anene, Nnamdi C.
name: Dangulbi, Bashir M.
name: Veiga, Marcello M. (Marcello Mariz)
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2024

description: The objective of this work was to establish the gold and mercury losses in an artisanal mining deposit (Uke) in Nigeria to convince miners about their inefficiency and suggest changes in their gold extraction practices. Samples of feeds and tailings from five sluice box concentration processes previously ground in hammer mills below 1 mm (P80 = 0.5 mm) were systematically sampled every 15 min. for 4 h and sent for gold analyses by a fire assay and intensive cyanidation. Dry grain size analyses of primary and amalgamation tailings allowed us to find out in which size fraction gold and mercury are lost. Total mercury losses in sixteen operations were obtained by weighing mercury at the beginning and in all steps of the concentrates’ amalgamation. After analyses, the average gold grade in the feed resulted in 3.80 ± 1.52 ppm (two standard deviations). The gold recovery was 29.24 ± 13.24%, which is low due to a lack of liberation of the fine gold particles from the gangue (silicates). Finer grinding would be necessary. The mercury balance revealed that 42% of the mercury added is lost, in which 26% involves tailings and 16% evaporated. The HgLost-to-AuProduced ratio was found to be 3.35 ± 9.46, which is exceedingly high for this type of amalgamation process that should have this ratio around 1. One reason is the excessive amount of mercury in the amalgams, 76.5 ± 38.12%, when the normal is around 40%–50%. Mercury lost by evaporation in open bonfires is clearly contaminating amalgamation operators (usually children), neighbours, and the environment. The Hg-contaminated tailings and primary tailings are sold to local cyanidation plants, and this can form toxic soluble Hg(CN)2 in the process. The results of this research were brought to the attention of the miners and other stakeholders, including the regulatory agencies of the government. The % gold recovery by amalgamation was not established in this study, but if this process recovers 50 to 60% of the liberated gold particles in a concentrate and 30% of gold was recovered in the sluice boxes, then the total gold recovery should be between 15 and 20; i.e., 80 to 85% of gold mined is lost. On average, an operation produces 8.26 g of gold/month, which is split to six miners, representing USD 69/month/miner or USD 2.3/day. It was discussed with miners, authorities, and community members (in particular female miners) how to avoid exposure to mercury, how to improve gold recovery without mercury, and the health and environmental effects of this pollutant.
L’educazione terapeutica alla gestione dell’astenia nel paziente oncologico: una revisione della letteratura
Creators: name: Zukic, Meris
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2020

description: Introduzione: questo Lavoro di Tesi ha l’obiettivo di raccogliere maggiori informazioni inerenti l’efficacia dell’educazione terapeutica alla gestione dell’astenia nei pazienti oncologici, al fine di rispondere al bisogno di maggiori informazioni inerenti l’argomento evidenziato dalla revisione sistematica di Bennett et al (Bennett et al., 2016) Metodo: il metodo utilizzato per la realizzazione di questo elaborato è stato quello della revisione della letteratura. La ricerca degli articoli da includere è stata condotta nelle banche dati PubMed e Cinahl. Gli studi considerati eleggibili dovevano rientrare nel periodo di tempo che incomincia il 01.01.2017 fino al 02.03.2020, giorno in cui è stata condotta la raccolta della letteratura. Sono stati inclusi studi clinici randomizzati controllati (RCT). Risultati: gli articoli inclusi in questa revisione sono stati sei, nei quali venivano condotti studi in cui veniva misurato l’Outcome dell’educazione terapeutica alla gestione della Fatigue nei pazienti oncologici. Sono stati utilizzati differenti interventi sperimentali e di controllo per verificare l’efficacia del progetto educativo per la riduzione dell’astenia correlata al cancro (educazione terapeutica individuale e di gruppo, sistemi elettronici, posta elettronica, …). I risultati di questa revisione seguono la stessa linea della revisione sistematica condotta da Bennett et al (Bennett et al., 2016), in quanto dagli articoli inclusi in questa ricerca emerge in termini generali un risultato positivo dagli studi RCT condotti sull’educazione terapeutica alla gestione dell’astenia nei pazienti oncologici. Conclusioni: questo Lavoro di Tesi verte ad evidenziare l’importanza della problematica dell’astenia correlata al cancro che è possibile incontrare nell’ambito dell’oncologia medica. La problematica della Fatigue nel paziente oncologico non viene presa in considerazione adeguatamente e di conseguenza non vengono offerte le cure appropriate per la riduzione di questo sintomo (NCCN, 2018). L’educazione terapeutica è un intervento infermieristico valido per la riduzione dell’astenia percepita dai pazienti affetti da cancro. Da questa revisione emerge nuovamente la necessita di condurre ulteriore ricerca sull’argomento, in modo da poter comprendere quali elementi deve avere il progetto educativo da erogare e quale caratteristiche deve presentare l’assistito. Parole chiave: Cancer, Fatigue, Patient Education, Health Education, Self Management, Oncology
Dysschema biformis subsp. biformis biformis (Schaus 1901
Creators: name: Vincent, Benoît
name: Laguerre, Michel
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Erebidae
Dysschema
Dysschema biformis
Dysschema biformis biformis (schaus, 1901)

description: Dysschema biformis biformis (Schaus, 1901)
Pericopis biformis Schaus, 1901a: 269.
Thebrone hilarina Weymer, 1914: 7. Type locality.— Brazil, [Pernambuco], São João.Type specimen. — Holotype female (ZMHB).
TYPE LOCALITY. — [Brazil], Paraná, Castro.
TYPE SPECIMENS. — Undisclosed number of male and female syntypes (USNM; one of the syntypes labeled Type no. 11 423).
description: Published as part of Vincent, Benoît & Laguerre, Michel, 2014, Catalogue of the Neotropical Arctiini Leach, [1815] (except Ctenuchina Kirby, 1837 and Euchromiina Butler, 1876) (Insecta, Lepidoptera, Erebidae, Arctiinae), pp. 137-533 in Zoosystema 36 (2) on page 474, DOI: 10.5252/z2014n2a1, http://zenodo.org/record/5395344
Modulare è sostenibile?: come influenzano le strategie orientate alla modularità sulle performance ambientali ed economiche del prodotto?
Creators: name: Hajdaj, Gentiana
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2016
Subjects: sostenibilità
gestione
costi
ambiente

description: Negli ultimi anni la modularità ha suscitato un interesse crescente, vi è infatti una sempre maggiore diffusione della strategia modulare all’interno delle aziende (Bordignon, 2007). Il presente lavoro si prefigge lo scopo di individuare se l’approccio modulare abbia effetti positivi sulla sostenibilità economica ed ambientale dei prodotti stessi e, più in generale, sulle performance dell’azienda. Si intende raccogliere, attraverso interviste ad aziende pertinenti, dati che permettano non solo di analizzare i vantaggi economici e ambientali derivanti dall’adozione della modularità, ma anche di comprendere quali siano le condizioni che consentono di adottare i principi della modularità e quanto il tema della sostenibilità ambientale rientri tra gli obiettivi perseguiti dall’azienda stessa. Al fine di raggiungere gli obiettivi sopraesposti è stata svolta in primo luogo un’analisi della letteratura, comprendente alcuni casi di studio, inerente alla tematica della modularità e degli aspetti economici ed ambientali ad essa correlati. In secondo luogo, sono state svolte sei interviste semi-strutturate ad aziende di settori e dimensioni differenti tra loro. Una di esse ha dichiarato di non adottare un approccio modulare all’interno della propria azienda. Conseguentemente, è stata svolta l’analisi dei dati raccolti e una discussione di essi in relazione alla letteratura. È risultato che tra le aziende che adottano modularità sono particolarmente percepiti i benefici economici, mentre quelli ambientali sono spesso trascurati. Per quanto riguarda i primi, si nota con chiarezza che i benefici principali sono legati all’aumento della varietà di prodotti, alla semplificazione della gestione di diverse aree (come ad esempio quella del magazzino, degli ordini e del trasporto) con conseguente riduzione dei costi delle stesse e in generale alla riduzione dei costi di produzione. Per quanto riguarda i benefici ambientali, sebbene questi non fossero immediatamente percepiti dalle imprese, è stato possibile individuarli, attraverso la considerazione dell’intero ciclo di vita del prodotto. In generale, i risultati ottenuti dalle interviste svolte risultano coerenti con quelli che emergono dall’analisi della letteratura e dei casi di studio.
ИЧКИ ИШЛАР ОРГАНЛАРИ ФАОЛИЯТИНИНГ ҲУҚУҚИЙ АСОСЛАРИ ВА МЕХАНИЗМЛАРИ
Creators: name: Парманов, Ф.Д.
Publisher: name: Zenodo
Year: 2024

description: Мақолада мамлакатимизда ички ишлар органлари фаолиятининг ҳуқуқий асослари ва механизмлари ёритилган. Муаллиф ўтган давр мобайнида ички ишлар органлари тизимини такомиллаштириш борасида кенг кўламли ислоҳотлар амалга оширилганлигини, айниқса, ички ишлар органларининг маҳаллаларда жамоат тартибини сақлаш, фуқаролар хавфсизлигини таъминлаш, ҳуқуқбузарликлар профилактикаси ва жиноятчиликка қарши курашиш учун ташкил этилган қуйи бўғинини ривожлантириш ва мустаҳкамлаш бўйича салмоқли ишлар қилинганлигини алоҳида эътибор қаратган..
CARMOLIT 2018 cruise,Thalia R/V
Creators: name: QUEMENER Loïc
Publisher: name: Sismer
Year: 2018

description: Cette campagne CARMOLIT2018 répond à une demande partagée entre Recherche, Technologie et Réseau d'observation/surveillance focalisée sur le site pilote de la Baie de Vilaine. L'objectif essentiel de cette opération à la mer est la mise en place de la bouée MOLIT. Cette bouée peut être aussi considérée comme un "laboratoire in situ", et c'est une des raisons pour laquelle cette bouée est intégrée dans le projet européen H2020 JERICO-NEXT et le CPER ROEC.
Cette station doit tenir sa place dans le réseau des bouées fournisseurs de données au centre de données CORIOLIS.
La bouée MOLIT constitue un des systèmes de mesure du réseau de mesure haute fréquence Ifremer HOSEA (High frequency Observation network for the environment in coastal SEAs). Suite à un rapprochement des réseaux d'observation côtiers entre l'INSU et l'IFREMER dans un réseau commun en cours de labellisation en tant que Service National d'Observation (futur réseau COAST-HF), la station de mesure de mesure MOLIT a été intégrée en décembre 2015, dans l'Infrastructure de Recherche LIttorale et CÔtière (IR ILICO).
Le projet européen JERICO NEXT a pour but de fédérer les réseaux de mesure in situ de 25 partenaires européens.
Dans le cadre du projet ROEC, de nouveaux équipements seront déployés pour permettre le développement de technologies innovantes et répondre à des problématiques scientifiques identifiées. La bouée MOLIT sera utilisée comme plateforme d'essais pour l'adaptation et la mise au point d'un nouveau profileur de mesure en continu (WIREWALKER, Rockland Scientific®) ainsi que l'automatisation de la cytométrie de flux (CytoSense,cytobuoy®) pour la détermination et la quantification phytoplanctonique.
Outre l'aspect fournisseur de données haute-fréquence, cette station de mesure est un élément déterminant dans la connaissance des masses d'eau du Mor Braz. En effet le site de déploiement en Baie de Vilaine, a été choisi pour ses spécificités et tout particulièrement pour les risques importants d'apparition de phénomènes d'hypoxie et même d'anoxie.
Cette station de mesure et de prélèvement est aussi positionnée à proximité d'un point de contrôle DCE. En effet, la station de mesure MOLIT est située dans une des trois masses d'eau du bassin Loire-Bretagne qui a un classement DCE non satisfaisant pour l'élément phytoplancton.
Dysschema biformis subsp. fulva
Creators: name: Vincent, Benoît
name: Laguerre, Michel
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Erebidae
Dysschema
Dysschema biformis
Dysschema biformis fulva (weymer, 1914)

description: Dysschema biformis fulva (Weymer, 1914)
Thebrone hilarina fulva Weymer, 1914: 7.
TYPE LOCALITY. — [Brazil], [Paraná].
TYPE SPECIMEN. — Holotype male (ZMHB).
description: Published as part of Vincent, Benoît & Laguerre, Michel, 2014, Catalogue of the Neotropical Arctiini Leach, [1815] (except Ctenuchina Kirby, 1837 and Euchromiina Butler, 1876) (Insecta, Lepidoptera, Erebidae, Arctiinae), pp. 137-533 in Zoosystema 36 (2) on page 474, DOI: 10.5252/z2014n2a1, http://zenodo.org/record/5395344
The tumor therapeutic potential of long non-coding RNA delivery and targeting
Creators: name: Chen, X
name: Han, S
name: Huang, L
Publisher: name: Chinese Academy of Medical Sciences
Year: 2023

description: Long non-coding RNAs (lncRNAs) is a type of RNA over 200 nt long without any protein coding ability, which has been investigated relating to crucial biological function in cells. There are many key lncRNAs in tumor/normal cells that serve as a biological marker or a new target for tumor treatment. However, compared to some small non-coding RNA, lncRNA-based drugs are limited in clinical application. Different from other non-coding RNA, like microRNAs, most lncRNAs have a high molecular weight and conserved secondary structure, making the delivery of lncRNAs more complex than the small non-coding RNAs. Considering that lncRNAs constitute the most abundant part of the mammalian genome, it is critical to further explore lncRNA delivery and the subsequent functional studies for potential clinical application. In this review, we will discuss the function and mechanism of lncRNAs in diseases, especially cancer, and different approaches for lncRNA transfection using multiple biomaterials.
3D reconstruction of BigBrain2: Progress report on semi-automated repairs of histological sections
Creators: name: Lepage, Claude
name: Mohlberg, Hartmut
name: Lewis, Lindsay B.
name: Toussaint, Paule-J.
name: Wenzel, Susanne
name: Evans, Alan C.
name: Amunts, Katrin
Publisher: name: Forschungzentrum Jülich
Year: 2024

description: 8th BigBrain Workshop, Padua, Heinrich-Heine-University Düsseldorf, Italy, 9 Sep 2024 - 11 Sep 2024
Green and Sustainable Cloud Computing: Strategies for Carbon Footprint Reduction and Energy Optimization
Creators: name: Dash, Abhiram
Publisher: name: Zenodo
Year: 2025

description: The quick growth of cloud computing has caused a revolution in industries allowing companies to expand operations, boost productivity, and come up with new ideas at speeds never seen before. Yet, this growth has brought big environmental effects. Data centers, which form the core of cloud computing, are facilities that use a lot of energy and add a lot to global carbon emissions. By 2030, experts think the energy needs of data centers in just the United States will triple making up to 12% of the country's total power use (McKinsey, 2024). This big jump in energy demand shows we need to adopt sustainable cloud computing methods to reduce environmental harm while meeting industries' growing need for computing power. A big reason for this growing energy need is the more complex tasks we're doing those powered by AI and machine learning. These game-changing technologies need a lot of computing power, which puts more strain on data centers and energy systems. Just the use of generative AI is likely to need 50 to 60 more gigawatts (GW) of data center space in the U.S. by 2030 (McKinsey, 2024). This growth shows the two-fold challenge: to scale up cloud systems while also cutting down their carbon output.
The WHO South-East Asia region nutrient profile model is quite appropriate for India: An exploration of 31,516 food products
Creators: name: Pandav C
name: Taillie L.S
name: Miles D.R
name: Hollingsworth B.A
name: Popkin B.M
Publisher: name: MDPI AG
Year: 2021

description: The rapid rise in prevalence of overweight/obesity, as well as high prevalence of type 2 diabetes and other nutrition-related noncommunicable diseases, has led the Food Safety and Standards Authority of India (FSSAI) to propose a front-of-package labeling (FOPL) regulation. An effective FOPL system applies a nutrient profile model that identifies foods high in sugar, sodium, and saturated fat that would receive a warning label for consumers to effectively discern between more and less healthy foods. Previous Nutrition Alchemy data collected by the food industry (n = 1306 products) estimated that approximately 96% of foods in India would have at least one warning label based on the FSSAI proposed FOPL. This near universal coverage of warning labels may be inaccurate and misleading. To address this, the current study compared two nutrient profile models, the WHO South-East Asia Region Organization (SEARO) and the Chilean Warning Octagon (CWO) Phase 3, applied to food products available in the Indian market from 2015–2020, collected through Mintel Global New Products Database (n = 10,501 products). Results suggest that 68% of foods and beverages would have at least one ‘ high-in’ level warning label. This study highlights the need to include a more comprehensive sample of food products for assessing the value of warning labels.
Calcein release from DPPC liposomes by phospholipase A2 activity: Effect of cholesterol and amphipathic copolymers
Creators: name: Soto-Arriaza, Marco
name: Ahumada, Eduardo Cena
name: Bonardd, Sebastián
name: Melendez, Jaime
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology
subject: FOS: Biological sciences
subject: Virology
subject: Computational Biology

description: In this study, we evaluated the impact of incorporating diblock and triblock amphiphilic copolymers, as well as cholesterol into DPPC liposomes on the release of a model molecule, calcein, mediated by exogenous phospholipase A2 activity. Our findings show that calcein release slows down in the presence of copolymers at low concentration, while at high concentration, the calcein release profile resembles that of the DPPC control. Additionally, calcein release mediated by exogenous PLA2 decreases as the amount of solubilized cholesterol increases, with a maximum between 18 mol% and 20 mol%. At concentrations higher than 24 mol%, no calcein release was observed. Studies conducted on HEK-293 and HeLa cells revealed that DPPC liposomes reduced viability by only 5% and 12%, respectively, after 3 hours of incubation, while DPPC liposome in presence of 33 mol% of Cholesterol reduced viability by approximately 11% and 23%, respectively, during the same incubation period. For formulations containing copolymers at low and high concentrations, cell viability decreased by approximately 20% and 40%, respectively, after 3 hours of incubation. Based on these preliminary results, we can conclude that the presence of amphiphilic copolymers at low concentration can be used in the design of new DPPC liposomes, and together with cholesterol, they can modulate liposome stabilization. The new formulations showed low cytotoxicity in HEK-293 cells, and it was observed that calcein release depended entirely on PLA2 activity and the presence of calcium ions.
QARZ INSTRUMENTI BO'LGAN OBLIGATSIYALARNI EMISSIYA QILISH VA ULAR ORQALI MOLIYAVIY MABLAG'LARNI JALB QILISH
Creators: name: Arifjanova, Yayraxon
Publisher: name: Zenodo
Year: 2024

description: Bugungi kunda yirik fond birjalarining asosiy moliyaviy instrumentlari bu korporativ qimmatli qog’ozlardir. Aksiyadorlik jamiyatlari zamonaviy moliyaviy intrumentlardan foydalangan holda kapital bahosi past bo’lgan moliyaviy resusrlarni qo’lga kiritishlari mumkin. Korporativ tuzilmalar o’z faoliyatini rivojlantirish, kengaytirish yoki modernatsiya qilish uchun qo’shimcha pul oqimiga extiyoj sezar ekan, ulush va qarz instrumentlaridan foydalanish imkoniyatlarini ko’rib chiqadi.
Therapeutic and delivery strategies of phytoconstituents for renal fibrosis
Creators: name: Xu, H
name: Wu, T
name: Huang, L
Publisher: name: Elsevier B.V.
Year: 2021

description: Chronic kidney disease (CKD) is one of the most common diseases endangering human health and life. By 2030, 14 per 100,000 people may die from CKD. Renal fibrosis (RF) is an important intermediate link and the final pathological change during CKD progression to the terminal stage. Therefore, identifying safe and effective treatment methods for RF has become an important goal. In 2018, the World Health Organization introduced traditional Chinese medicine into its effective global medical program. Various phytoconstituents that affect the RF process have been extracted from different plants. Here, we review the potential therapeutic capabilities of active phytoconstituents in RF treatment and discuss how phytoconstituents can be structurally modified or combined with other ingredients to enhance efficiency and reduce toxicity. We also summarize phytoconstituent delivery strategies to overcome renal barriers and improve bioavailability and targeting.
Dysschema boisduvallii
Creators: name: Vincent, Benoît
name: Laguerre, Michel
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Erebidae
Dysschema
Dysschema boisduvallii

description: Dysschema boisduvallii (van der Hoeven, 1840)
Glaucopis boisduvallii van der Hoeven, 1840: 279.
Arctia funeralis Herrich-Schäffer, [1856] a: wrapper to pl. 92, fig. 527. — Type locality: [South America] Am [Erica] Aequin [octialis]. — Type specimens: Undisclosed number of male syntypes (BMNH; one specimen labeled “ Syntype?”).
Daritis trapeziata Walker, [1865] a: 281. — Type locality: [South America]. — Type specimens: Undisclosed number of female syntypes (BMNH; one specimen labeled Holotype (!)).
Mazaeras woodii Butler, 1867: 218. — Type locality: [Brazil], Bahia. — Type specimens: Undisclosed number of female syntypes (?).
Pericopis rubripicta Butler, 1872a: 50. — Type locality: [Colombia], [Cundinamarca], Bogotá.— Type specimens: Undisclosed number of syntypes (UMO; one female syntype labeled TYPE no. 349).
Pericopis regalis Jörgensen, 1935: 117. — Type locality: [Argentina], Formosa, Guaycoléc. — Type specimen: Holotype female no. 32796 (MACN).
Pericopis principalis Jörgensen, 1935: 119. — Type locality: Paraguay, [Itapua], Trinidad. — Type specimens: Undisclosed number of female syntypes [“ejemplar tipico ha depararecido” typical specimen has disappeared].
TYPE LOCALITY. — Brazil.
TYPE SPECIMENS. — Undisclosed number of male syntypes (BMNH; one specimen labeled Syntype?).
REMARK
The type locality of Pericopis rubripicta is very likely wrong, this species being exclusively found in southeast Brazil.
description: Published as part of Vincent, Benoît & Laguerre, Michel, 2014, Catalogue of the Neotropical Arctiini Leach, [1815] (except Ctenuchina Kirby, 1837 and Euchromiina Butler, 1876) (Insecta, Lepidoptera, Erebidae, Arctiinae), pp. 137-533 in Zoosystema 36 (2) on page 474, DOI: 10.5252/z2014n2a1, http://zenodo.org/record/5395344
Dryopteris aizoides
Creators: name: Becherer
Publisher: name: Zenodo
Year: 1956
Subjects: Biodiversity
Taxonomy

description: S. aizoides X caesia Cat. 159 und 426. Keineneuen Fundorte bekanntgeworden.
description: Published as part of Becherer, 1956, Florae Vallesiacae Supplementum, pp. 1-556 in Denkschriften der Schweizerischen Naturforschenden Gesellschaft 71 on pages 1-556
Antithrombotic coating with sheltered positive charges prevents contact activation by controlling factor XII–biointerface binding
Creators: name: Ji, Haifeng
name: Yu, Kai
name: Abbina, Srinivas
name: Xu, Lin
name: Xu, Tao
name: Cheng, Shengjun
name: Vappala, Sreeparna
name: Arefi, S.M. Amin
name: Rana, Md Mohosin
name: Chafeeva, Irina
name: Drayton, Matthew
name: Gonzalez, Kevin
name: Liu, Yun
name: Grecov, Dana
name: Conway, Edward M.
name: Zhao, Weifeng
name: Zhao, Changsheng
name: Kizhakkedathu, Jayachandran N.
Publisher: name: The University of British Columbia
Year: 2024

description: Antithrombotic surfaces that prevent coagulation activation without interfering with haemostasis are required for blood-contacting devices. Such materials would restrain device-induced thrombogenesis and decrease the need for anticoagulant use, thereby reducing unwanted bleeding. Here, by optimizing the interactions with coagulation factor XII rather than preventing its surface adsorption, we develop a substrate-independent antithrombotic polymeric coating with sheltered positive charges. The antithrombic properties of the coating were demonstrated in vitro with human blood and in vivo using a carotid artery–jugular vein shunt model in rabbits. The coating exhibits a strong interaction with factor XII but results in a low reciprocal activation of the contact pathway that triggers clot formation. These findings contradict the prevailing strategy of designing antithrombotic materials through protein-repelling surfaces. Overall, the polymeric coating we describe can benefit most blood-contacting devices and is a useful engineering guideline for designing surfaces with improved antithrombotic properties.
Time to treatment disruption in children with HIV-1 randomized to initial antiretroviral therapy with protease inhibitors versus nonnucleoside reverse transcriptase inhibitors
Creators: name: Golin C.E
name: Warshaw M.G
name: Cole S.R
name: Ludema C
name: Yin D.E
name: McKinney R.E
name: Miller W.C
Publisher: name: Public Library of Science
Year: 2020

description: Background Choice of initial antiretroviral therapy regimen may help children with HIV maintain optimal, continuous therapy. We assessed treatment-naïve children for differences in time to treatment disruption across randomly-assigned protease inhibitor versus non-nucleoside reverse transcriptase inhibitor-based initial antiretroviral therapy. Methods We performed a secondary analysis of a multicenter phase 2/3, randomized, open-label trial in Europe, North and South America from 2002 to 2009. Children aged 31 days to <18 years, who were living with HIV-1 and treatment-naive, were randomized to antiretroviral therapy with two nucleoside reverse transcriptase inhibitors plus a protease inhibitor or nonnucleoside reverse transcriptase inhibitor. Time to first documented treatment disruption to any component of antiretroviral therapy, derived from treatment records and adherence questionnaires, was analyzed using Kaplan-Meier estimators and Cox proportional hazards models. Results The modified intention-to-treat analysis included 263 participants. Seventy-two percent (n = 190) of participants experienced at least one treatment disruption during study. At 4 years, treatment disruption probabilities were 70% (protease inhibitor) vs. 63% (non-nucleoside reverse transcriptase inhibitor). The unadjusted hazard ratio (HR) for treatment disruptions comparing protease inhibitor vs. non-nucleoside reverse transcriptase inhibitor-based regimens was 1.19, 95% confidence interval [CI] 0.88-1.61 (adjusted HR 1.24, 95% CI 0.91- 1.68). By study end, treatment disruption probabilities converged (protease inhibitor 81%, non-nucleoside reverse transcriptase inhibitor 84%) with unadjusted HR 1.11, 95% CI 0.84- 1.48 (adjusted HR 1.13, 95% CI 0.84-1.50). Reported reasons for treatment disruptions suggested that participants on protease inhibitors experienced greater tolerability problems. Conclusions Children had similar time to treatment disruption for initial protease inhibitor and non-nucleoside reverse transcriptase inhibitor-based antiretroviral therapy, despite greater reported tolerability problems with protease inhibitor regimens. Initial pediatric antiretroviral therapy with either a protease inhibitor or non-nucleoside reverse transcriptase inhibitor may be acceptable for maintaining optimal, continuous therapy.
Tinagl1 Gene Therapy Suppresses Growth and Remodels the Microenvironment of Triple Negative Breast Cancer
Creators: name: Musetti, S.N
name: Huang, L
Publisher: name: American Chemical Society
Year: 2021

description: Triple negative breast cancer (TNBC) remains one of the most challenging subtypes of breast cancer to treat and is responsible for approximately 12% of breast cancer cases in the US per year. In 2019, the protein Tinagl1 was identified as a key factor for improved prognoses in certain TNBC patients. While the intracellular mechanism of action has been thoroughly studied, little is known about the role of Tinagl1 in the tumor microenvironment. In this study, we developed a lipid nanoparticle-based gene therapy to directly target the expression of Tinagl1 in tumor cells for localized expression. Additionally, we sought to characterize the changes to the tumor microenvironment induced by Tinagl1 treatment, with the goal of informing future choices for combination therapies including Tinagl1. We found that Tinagl1 gene therapy was able to slow tumor growth from the first dose and that the effects held steady for nearly a week following the final dose. No toxicity was found with this treatment. Additionally, the use of Tinagl1 increases the tumor vasculature by 3-fold but does not increase the tumor permeability or risk of metastasis. However, the increase in vasculature arising from Tinagl1 therapy reduced the expression of Hif1a significantly (p < 0.01), which may decrease the risk of drug resistance.
CAROBAN cruise,Sepia II R/V
Creators: name: TESSIER Bernadette
Publisher: name: Sismer
Year: 1998

description: Carottage des bancs de sable situés au large de Dunkerque pour la caractérisation lithologique de leur structure interne et, si possible, leur datation.Le projet de rattachement est un projet inscrit parmi les thématiques de l'URA 719 "Sédimentologie et Géodynamique" et de l'URM 17.
Dysschema centenaria subsp. centenaria
Creators: name: Vincent, Benoît
name: Laguerre, Michel
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Erebidae
Dysschema
Dysschema centenaria
Dysschema centenaria centenaria (burmeister, 1878)

description: Dysschema centenaria centenaria
(Burmeister, 1878)
Eucharia centenaria Burmeister, 1878: 436.
Pericopis jaonis Strand, 1911c: 77. — Type locality: Brazil, [Pernambuco], [São João] Sã[o] Jão. — Type specimen: Holotype female (BMNH).
TYPE LOCALITY. — Argentina, [Buenos Aires], Zarate.
TYPE SPECIMEN. — Holotype male (MACN).
description: Published as part of Vincent, Benoît & Laguerre, Michel, 2014, Catalogue of the Neotropical Arctiini Leach, [1815] (except Ctenuchina Kirby, 1837 and Euchromiina Butler, 1876) (Insecta, Lepidoptera, Erebidae, Arctiinae), pp. 137-533 in Zoosystema 36 (2) on page 474, DOI: 10.5252/z2014n2a1, http://zenodo.org/record/5395344
La difficoltà di accettare il proprio corpo nelle giovani donne. Possibili spazi di intervento educativo da parte dell’operatore sociale
Creators: name: Tritten Kotkova, Dagmar
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2022
Subjects: corpo
giovani donne
ideali
bellezza
social network
lavoro educativo di strada
servizio di prossimit
Lugano
educativa di strada
outreach approach
prevenzione
disturbi alimentari
DCA
standard
operatore sociale
operatore di prossimità
identità
autostima
vergogna
immagine di sé
instagram
prospettiva femminista
body positivity
body shaming

description: Questa ricerca è stata sviluppata all’interno della cornice del Servizio di prossimità della città di Lugano, cercando di comprendere come viene vissuto il tema dell’insoddisfazione corporea nelle giovani donne in relazione ai social network attraverso delle interviste semi-strutturate ad alcune di coloro che lo frequentano, oltre che agli operatori che vi lavorano. A tal fine, è stata sviluppata la seguente domanda di ricerca: “In che modo viene presa in considerazione la tematica dell’insoddisfazione corporea nelle giovani donne da parte degli operatori di prossimità della città di Lugano?”. La ricerca ha permesso di rilevare che il fenomeno è sentito e tocca diversi aspetti dell’identità della persona oltre che del in cui si rapporta con il mondo esterno. Inoltre, ad oggi, sembrerebbe che non vi siano sufficienti strumenti e servizi educativi per poterne permettere una presa in carico adeguata. Questo lavoro si pone dunque come riflettore per un aspetto del lavoro educativo con le giovani sicuramente attuale, data l’onnipresenza dell’immagine, così come dei social network, che permea oggigiorno. Inoltre, l’auspicio è quello di permettere agli operatori sociali una riflessione rispetto alle implicazioni di un fenomeno strettamente legato alle questioni di genere.
CAROBAN 2 cruise,Cote D'Aquitaine R/V
Creators: name: TESSIER Bernadette
Publisher: name: Sismer
Year: 1999

description: Vibrocarottage sur les bancs côtiers de Dunkerque dans le but de confirmer les interprétations tirées à partir des données sismiques déjà disponibles pour ces bancs. La zone couverte est la zone des bancs sableux (Snow et Braek) situés immédiatement au large de Dunkerque, le long du chenal d'accès aux ports Est et Ouest.
CAROBAN 3 cruise,Cote D'Aquitaine R/V
Creators: name: TESSIER Bernadette
Publisher: name: Sismer
Year: 1999

description: Vibrocarottage sur les bancs côtiers de Dunkerque dans le but de confirmer les interprétations tirées à partir des données sismiques déjà disponibles pour ces bancs. La zone couverte est la zone des bancs sableux (Snow et Braek) situés immédiatement au large de Dunkerque, le long du chenal d'accès aux ports Est et Ouest.
Dysschema innominatum Becker 2013
Creators: name: Vincent, Benoît
name: Laguerre, Michel
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Erebidae
Dysschema
Dysschema innominatum

description: Dysschema innominatum Becker, 2013
Dysschema innominatum Becker, 2013: 58.
TYPE LOCALITY. — Brazil, Saõ Paulo, Campos do Jordão.
TYPE SPECIMEN. — Holotype male (UFPC).
description: Published as part of Vincent, Benoît & Laguerre, Michel, 2014, Catalogue of the Neotropical Arctiini Leach, [1815] (except Ctenuchina Kirby, 1837 and Euchromiina Butler, 1876) (Insecta, Lepidoptera, Erebidae, Arctiinae), pp. 137-533 in Zoosystema 36 (2) on page 475, DOI: 10.5252/z2014n2a1, http://zenodo.org/record/5395344
CAROLOIRE cruise,Thalia R/V
Creators: name: PROUST Jean-Noël
name: Isabelle, THINON
Publisher: name: Sismer
Year: 2012

description: Echantillonnage, pour validation géologique, d'unités sismiques identifiées lors des campagnes côtières effectuées antérieurement à cette mission au sud de la Bretagne. Il s'agit : (1) Dans le secteur Loire, de prélever des sédiments avec le vibro-carottier Zenkovitch dans les sédiments meubles des vallées fossiles de la Loire pour préciser la nature des sédiments et leur environnement de dépôt et, de prélever avec le carottier-roche des échantillons dans le substratum des vallées; (2) Dans le secteur du Banc Bertin, de prélever des échantillons de roches (carottier-roche) et de sédiment (Zenkovitch) pour statuer sur la présence d'Oligocène, vérifier la présence de craie fossilifère trouvée dans les années 70 et, dater les principales discordances observées en sismique entre les calcaires du Bartonien-Lutétien et les craies du Danien supposé. En cas de mauvais temps, ou problème technique : acquisition de données sismiques THR. Le projet de rattachement est le projet RGF (Référentiel Géologique de la France) du BRGM.
CAROBSEINE cruise,Thalia R/V
Creators: name: TESSIER Bernadette
name: Isabelle, THINON
Publisher: name: Sismer
Year: 2009

description: Prélèvements par vibrocarottage et avec un carottier à roches dans la baie de Seine dans le but de calibrer les données sismiques acquises depuis 2007. L'objectif général du projet auquel se rattache la campagne Carobseine est l'étude de l'évolution cénozoïque de la baie de Seine. L'objectif final est de bâtir pour ce type de bassin sédimentaire un modèle d'architecture précis dans un cadre stratigraphique bien défini, de préciser les relations géométriques entre les entités cénozoïques (paléovallées, prismes côtiers) et de définir le rôle de la morphologie et de la nature du substratum géologique sous-jacent, dans la localisation, la géométrie et l'évolution de ces différentes entités. Ces travaux sont réalisés dans le cadre de la thèse de Massinissa Benabdelhouahed (Université de Caen) cofinancée par la Région Basse-Normandie et le BRGM.La mission Carobseine fait suite à trois missions de prospections sismiques réalisées en 2007 et 2008 (BaieSeine07 - cf. Figure 1, Seine THR, Seine HR). Elle a deux objectifs principaux : des prélèvements par vibrocarottages dans les accumulations côtières récentes (Holocènes) reconnues en sismique THR, des prélèvements par carottier à roche pour préciser la stratigraphie des assises du substratum reconnues en sismique HR.La campagne est rattachée au projet de recherche BRGM Transition Terre-Mer.
Il ruolo del docente in educazione fisica
Creators: name: Zanini, Luca
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2015

description: Questo lavoro intende chiarire il ruolo del docente in educazione fisica dopo il cambiamento concettuale, passaggio da disciplinocentrismo ad allievocentrismo, avvenuto nella disciplina. L’intervento del docente nella ricerca è orientato principalmente verso la stimolazione di processi metacognitivi negli allievi. Per la raccolta dati, gli allievi di una classe sono stati filmati e hanno risposto ad un questionario dopo essersi confrontati con sei situazioni motorie diverse tra loro per: concetto di programmazione ed entità d'intervento del docente. I risultati hanno messo in evidenza come la conoscenza degli obiettivi e dei fattori di riuscita, da parte degli allievi, in una situazione motoria allievocentrica sia influenzata dall'intervento del docente. Non è stato possibile trarre altre conclusioni definitive, anche se alcuni dati fanno ipotizzare che l’influenza continua del docente. Relatori: Alejandro Arigoni, Flavio Rossi, Francesco Canuti. Materia: Educazione fisica.
MXene/Bacterial Cellulose Hybrid Materials for Sustainable Soft Electronics
Creators: name: Guziewicz, Wojciech
name: Srivatsa, Shreyas
name: Zambrzycki, Marcel
name: Dziadek, Michał
name: Szatkowski, Piotr
name: Szymczak, Patryk
name: Berent, Katarzyna
name: Marciszko-Wiąckowska, Marianna
name: Radecka, Marta
name: Kołodziejczyk, Agata
name: Uhl, Tadeusz
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2024

description: This work evaluated bacterial cellulose (BC) as a possible biodegradable soft electronics substrate in comparison to polyethylene terephthalate (PET), while also focusing on evaluating hybrid MXene/BC material as potential flexible electronic sensor. Material characterization studies revealed that the BC material structure consists of nanofibers with diameters ranging from 70 to 140 nm, stacked layer-by-layer. BC samples produced are sensitive to post-treatment with isopropanol resulting in a change of structural and mechanical properties. The viscoelastic properties of the BC substrates have been studied experimentally in comparison with the PET film. Aged BC substrate showcased similar viscoelastic properties stability, while exhibiting better properties above 70 °C, with total storage modulus change of −15% and loss modulus change of 21%. MXenes prepared using the Minimally Intensive Layer Delamination (MILD) method were screen-printed onto BC substrates and PET films to form MXene/BC (MX/BC) and MXene/PET (MX/PET) devices. The electrical properties results showcased different resistive behavior on both BC and PET substrate samples with different impedance moduli. MX/PET presented lower sheet resistance of around 156 Ω·sq−1, while MX/BC was 2733 Ω·sq−1. Finally, the MX/BC and MX/PET devices were subjected to repeatable quasi-static load tests and the piezoresistive sensing behavior of the devices has been reported.