cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
UNDERSTANDING THE CONTRIBUTIONS OF THE POLYCOMB CBX PARALOGS IN BINDING AND ONCOGENSIS
Creators: name: Connelly, Katelyn E.
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Oncology and carcinogenesis not elsewhere classified
Biochemistry and cell biology not elsewhere classified
Epigenetics (incl. genome methylation and epigenomics)
Plant cell and molecular biology
Animal cell and molecular biology
Pharmacology and pharmaceutical sciences not elsewhere classified

description: The transcriptional repressor Polycomb Repressive Complex 1 (PRC1) is critical for stem cell maintenance and proper differentiation and as such is involved in the development and progression of cancer. Canonical PRC1, composed of PCGF, PHC, RING and CBX, binds histone H3 lysine 27 trimethylation (H3K27me3) allowing for ubiquitination, chromatin compaction and subsequently transcriptional silencing. In mammals, each subunit has multiple paralogs creating functional and compositional diversity. The greatest diversity is contributed by the CBX targeting subunit with five mutually exclusive paralogs (CBX2/4/6/7/8). The CBX paralogs contain an N-terminal chromodomain for methyllysine binding. There has been interest in the CBX paralogs due to their misregulation in various cancers and the “druggability” of the chromodomain histone interaction. However, the unique biochemical and transcriptional functions of the paralogs are unclear. Expression changes during lineage specification and the context-dependent misregulation of CBX paralogs in cancers suggest the paralogs have paralog-specific functions. However, little has been done to define differences in paralog-mediated chromatin binding and regulation. This work utilizes a variety of approaches to tease apart the biological and biochemical functions of the CBX paralogs in chromatin binding and oncogenesis. In this dissertation, we identify a combinatorial therapeutic strategy using a CBX chromodomain inhibitor to enhance chemotherapeutic response. Further, this work demonstrates a role for CBX8 and its chromodomain in glioblastoma oncogenesis suggesting it may serve as a therapeutic target. Finally, we identify a binding mechanism for the CBX8 chromodomain in which DNA and H3K27me3 binding contribute to full chromatin association.
Imported cholera with acute renal failure after a short business-trip to the Philippines, Germany, October 2015
Creators: name: Slesak, G.
name: Fleck, R.
name: Jacob, Daniela
name: Grunow, Roland
name: Schäfer, J.
Publisher: name: Robert Koch-Institut, Biologische Sicherheit
Year: 2016
Subjects: subject: Germany
subject: Humans
subject: Male
subject: Middle Aged
subject: Genotype
subject: Real-Time Polymerase Chain Reaction
subject: Feces/microbiology
subject: Treatment Outcome
subject: Travel
subject: Cholera/diagnosis
subject: Cholera/microbiology
subject: Cholera/therapy
subject: Diarrhea/etiology
subject: Infusions Intravenous
subject: Philippines
subject: Renal Insufficiency/complications
subject: Vibrio cholerae O1/genetics
subject: Vibrio cholerae O1/isolation & purification
subject: 610 Medizin

description: A German businessman developed acute watery diarrhoea after a three-day trip to the Philippines. He was admitted with severe hypotension and acute renal failure, but recovered with rapid rehydration. Vibrio cholerae O1 serotype Ogawa was isolated. Physicians need to be aware of endemic cholera in Asia including the Philippines and consider this in their pre-travel advice.
Contrato social y posapocalipsis en Los perros del fin del mundo y Ciudad de zombis de Homero Aridjis
Creators: name: Guerra, Aurelio
Publisher: name: Humanities Commons
Year: 2016
Subjects: subject: Latin American literature

description: El mundo posapocalíptico en la fi cción suele representarse como un sitio hobbesiano en el que la ausencia de un contrato social mantiene al hombre en una lucha constante por la sobrevivencia. En Ciudad de Zombis y Los perros del fi n del mundo, Homero Aridjis representa el México actual como un sitio distópico sin más orden ni ley que la que impone el crimen y la violencia. A pesar de este escenario, el espacio representado en estas novelas no carece de contrato social, pues en este se mantienen activas las instituciones de la vida moderna. En este artículo propongo que esta situación contradictoria apunta a una interpretación posapocalíptica de la sociedad en el México contemporáneo.
Additional file 3 of Neighboring macrophage-induced alteration in the phenotype of colorectal cancer cells in the tumor budding area
Creators: name: Kawamura, Ichiro
name: Ohe, Rintaro
name: Suzuki, Kazushi
name: Kabasawa, Takanobu
name: Kitaoka, Takumi
name: Takahara, Daiichiro
name: Kono, Michihisa
name: Uchiyama, Naoya
name: Musha, Hiroaki
name: Futakuchi, Mitsuru
name: Motoi, Fuyuhiko
Publisher: name: figshare
Year: 2024
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Additional file 3: Supplemental Table S2. Univariate and multivariative analyses for overall survival and relapse-free survival.
Supplemental Material, sj-docx-3-cll-10.1177_09636897211023474 - Label-Free Quantitative Proteome Profiling of Cerebrospinal Fluid from a Rat Stroke Model with Stem Cell Therapy
Creators: name: Hur, Junseok W
name: Kim, Min-Sik
name: Oh, Se-Yeon
name: Kang, Ho-Young
name: Bae, Jingi
name: Kim, Hokeun
name: Lee, Hangyeore
name: Lee, Sang-Won
name: Park, Dong-Hyuk
Publisher: name: SAGE Journals
Year: 2021
Subjects: Medicine
Cell Biology

description: Supplemental Material, sj-docx-3-cll-10.1177_09636897211023474 for Label-Free Quantitative Proteome Profiling of Cerebrospinal Fluid from a Rat Stroke Model with Stem Cell Therapy by Junseok W Hur, Min-Sik Kim, Se-Yeon Oh, Ho-Young Kang, Jingi Bae, Hokeun Kim, Hangyeore Lee, Sang-Won Lee and Dong-Hyuk Park in Cell Transplantation
BUILDING INFORMATION MODELING (BIM) - TO PREPARE CURRENT CONSTRUCTION MANAGEMENT STUDENTS FOR TOMORROW’S CONSTRUCTION CAREERS
Creators: name: Cory, Clark A.
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Building construction management and project planning

description: Building Information Modeling, or BIM, is a process that is quickly changing the way Architectural, Engineering, and Construction companies manage construction projects. Being a company specific process, only parts of the process have been accepted as a standardized method across every company. Those components that are not standardized have become proprietary to each specific company. The goal of the research is to provide a rich and complete description of the use of BIM across multiple Architectural, Engineering and Construction (AEC) companies in order to inform and integrate BIM into construction graphics and management curricula in higher education. The literature review generated a thorough understanding of BIM standards currently identified. The methodology, a comparison of BIM theory to industrial practices, provided a broader picture of all aspects of BIM being utilized in current AEC companies. The results identified a comparison of all aspects of BIM to current AEC practices and paints a well-defined picture of what is being accomplished with BIM within company construction processes across AEC companies that are classified into several categories. BIM practices within each company indicate similarities and differences that give a rich BIM description across the entire AEC industry. The results suggest a high usage of BIM across more areas than just construction of the building branching out to all areas within a set of construction documents for project management.
sj-docx-1-smo-10.1177_20503121211026195 – Supplemental material for Mental health effect of COVID-19 pandemic among women who are pregnant and/or lactating: A systematic review and meta-analysis
Creators: name: Demissie, Dereje Bayissa
name: Bitew, Zebenay Workneh
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: Cardiology
subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine
subject: 110305 Emergency Medicine
subject: 110306 Endocrinology
subject: 110308 Geriatrics and Gerontology
subject: 110904 Neurology and Neuromuscular Diseases
subject: 111099 Nursing not elsewhere classified
subject: 111199 Nutrition and Dietetics not elsewhere classified
subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: 110314 Orthopaedics
subject: 110604 Sports Medicine
subject: 110315 Otorhinolaryngology
subject: 111702 Aged Health Care
subject: 111403 Paediatrics
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 110203 Respiratory Diseases
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology
subject: 110323 Surgery
subject: 70706 Veterinary Medicine
subject: FOS: Veterinary sciences

description: Supplemental material, sj-docx-1-smo-10.1177_20503121211026195 for Mental health effect of COVID-19 pandemic among women who are pregnant and/or lactating: A systematic review and meta-analysis by Dereje Bayissa Demissie and Zebenay Workneh Bitew in SAGE Open Medicine
Additional file 1 of Validation of the Arabic version of the cyberchondria severity scale 12 items (CSS-12-Ar) among a sample of Lebanese adults
Creators: name: Hallit, Souheil
name: Rogoza, Radosław
name: Abi Semaan, Carl
name: Azzi, Vanessa
name: Sawma, Toni
name: Obeid, Sahar
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biological Sciences not elsewhere classified
Science Policy
Mental Health

description: Supplementary Material 1: Cyberchondria Severity Scale (CSS-12-Ar)
L'egoismo di Federigo Tozzi
Creators: name: Ardolino, Francesco
Publisher: name: Humanities Commons
Year: 2012
Subjects: subject: Italian literature
subject: Literature--Philosophy
subject: Psychology and literature

description: Lettura della trilogia tozziana di prose poetiche ("Bestie", "Cose" e "Persone") sulla base delle confluenze con l'opera stirneriana "L'unico e la sua proprietà".
Additional file 1 of Correlation analysis between occupational stress and metabolic syndrome in workers of a petrochemical enterprise: based on two assessment models of occupational stress
Creators: name: Zhang, Min
name: Liu, Bin
name: Ke, Weiyi
name: Cai, Yashi
name: Zhang, Lingyu
name: Huang, Weixu
name: Yan, Xuehua
name: Chen, Huifeng
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Supplementary Material 1
sj-docx-1-tam-10.1177_17588359211022886 – Supplemental material for The value of circulating fibrinogen-to-pre-albumin ratio in predicting survival and benefit from chemotherapy in colorectal cancer
Creators: name: Ying, Hou-Qun
name: Sun, Fan
name: Liao, Yu-Cui
name: Cai, Dan
name: Yang, Ying
name: Cheng, Xue-Xin
Publisher: name: SAGE Journals
Year: 2021
Subjects: Oncology and Carcinogenesis not elsewhere classified
Aged Health Care
Pharmacology and Pharmaceutical Sciences not elsewhere classified
Respiratory Diseases

description: Supplemental material, sj-docx-1-tam-10.1177_17588359211022886 for The value of circulating fibrinogen-to-pre-albumin ratio in predicting survival and benefit from chemotherapy in colorectal cancer by Hou-Qun Ying, Fan Sun, Yu-Cui Liao, Dan Cai, Ying Yang and Xue-Xin Cheng in Therapeutic Advances in Medical Oncology
Recommended Immunological Assays to Screen for Ricin-Containing Samples
Creators: name: Simon, Stéphanie
name: Worbs, Sylvia
name: Avondet, Marc-André
name: Tracz, Dobryan M.
name: Dano, Julie
name: Schmidt, Lisa
name: Volland, Hervé
name: Dorner, Brigitte
name: Corbett, Cindi R.
Publisher: name: Robert Koch-Institut, Biologische Sicherheit
Year: 2015
Subjects: subject: ricin
subject: immunological detection
subject: enzyme linked immunosorbent assay
subject: lateral flow assay
subject: proficiency test
subject: 610 Medizin

description: Ricin, a toxin from the plant Ricinus communis, is one of the most toxic biological agents known. Due to its availability, toxicity, ease of production and absence of curative treatments, ricin has been classified by the Centers for Disease Control and Prevention (CDC) as category B biological weapon and it is scheduled as a List 1 compound in the Chemical Weapons Convention. An international proficiency test (PT) was conducted to evaluate detection and quantification capabilities of 17 expert laboratories. In this exercise one goal was to analyse the laboratories’ capacity to detect and differentiate ricin and the less toxic, but highly homologuous protein R. communis agglutinin (RCA120). Six analytical strategies are presented in this paper based on immunological assays (four immunoenzymatic assays and two immunochromatographic tests). Using these immunological methods “dangerous” samples containing ricin and/or RCA120 were successfully identified. Based on different antibodies used the detection and quantification of ricin and RCA120 was successful. The ricin PT highlighted the performance of different immunological approaches that are exemplarily recommended for highly sensitive and precise quantification of ricin.
sj-pdf-1-nms-10.1177_14614448211018160 – Supplemental material for Only “sheep” trust journalists? How citizens’ self-perceptions shape their approach to news
Creators: name: Nelson, Jacob L
name: Lewis, Seth C
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications

description: Supplemental material, sj-pdf-1-nms-10.1177_14614448211018160 for Only “sheep” trust journalists? How citizens’ self-perceptions shape their approach to news by Jacob L Nelson and Seth C Lewis in New Media & Society
ASSESSING RETENTION AND ADEQUACY OF EMERGENCY RESPONSE TRAINING FOR A POINT OF DISTRIBUTION (POD) EXERCISE
Creators: name: Craig, Colby R.
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Vocational education and training curriculum and pedagogy
Educational administration, management and leadership

description: The goal of the research is to help government agencies and non-profit-organizations (NPOs) better prepare for events that require a point-of-dispensing (POD) unit. The research team developed a training exercise that simulated a real world anthrax outbreak, by using groups of untrained nursing and pharmacy students. These students were then separated and trained in two different groups: asynchronously and synchronously. By outlining how to successfully reuse a point-of-dispensing (POD) unit during emergencies, the researcher compared Qualtrics surveys that were distributed at the beginning and end of the exercise. These surveys were meant to show students’ understanding of POD exercises and then evaluate their understanding of pivotal concepts (retention, cost, new algorithms, and teaching methods). It was found that the retention of new material dropped drastically after two months regardless of the type training. The first month retention dropped to 77% and the second to 46%. On top of the retention needed, eight trained volunteers would need to be stationed for every 100 people attending the POD. No city would be able to supply the amount of trained professionals required to satisfy these requirements, so untrained civilians would need to be used. The cost associated with consistently training this amount of untrained citizens would surpass any budget. The only feasible chance to train the amount of volunteers needed, would be to have the material readily available ahead of time. Asynchronous training is the only viable means to producing a training program with the scale and retention levels that a real world event would require.
Epidemiology of Epidemic Ebola Virus Disease in Conakry and Surrounding Prefectures, Guinea, 2014–2015
Creators: name: Rico, Adriana
name: Brody, Debra
name: Coronado, Fátima
name: Rondy, Marc
name: Fiebig, Lena
name: Carcelen, Andrea
name: Deyde, Varough M.
name: Mesfin, Samuel
name: Retzer, Kyla D.
name: Bilivogui, Pepe
name: Keita, Sakoba
name: Dahl, Benjamin A.
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2016
Subjects: subject: Africa
subject: epidemic
subject: Ebola
subject: Ebola Virus Disease
subject: Guinea
subject: control
subject: viruses
subject: 610 Medizin

description: In 2014, Ebola virus disease (EVD) in West Africa was first reported during March in 3 southeastern prefectures in Guinea; from there, the disease rapidly spread across West Africa. We describe the epidemiology of EVD cases reported in Guinea’s capital, Conakry, and 4 surrounding prefectures (Coyah, Dubreka, Forecariah, and Kindia), encompassing a full year of the epidemic. A total of 1,355 EVD cases, representing ≈40% of cases reported in Guinea, originated from these areas. Overall, Forecariah had the highest cumulative incidence (4× higher than that in Conakry). Case-fatality percentage ranged from 40% in Conakry to 60% in Kindia. Cumulative incidence was slightly higher among male than female residents, although incidences by prefecture and commune differed by sex. Over the course of the year, Conakry and neighboring prefectures became the EVD epicenter in Guinea.
Anthropometric markers and their association with incident type 2 diabetes mellitus: which marker is best for prediction? Pooled analysis of four German population-based cohort studies and comparison with a nationwide cohort study
Creators: name: Hartwig, Saskia
name: Kluttig, Alexander
name: Tiller, Daniel
name: Fricke, Julia
name: Müller, Grit
name: Schipf, Sabine
name: Völzke, Henry
name: Schunk, Michaela
name: Meisinger, Christa
name: Schienkiewitz, Anja
name: Heidemann, Christin
name: Moebus, Susanne
name: Pechlivanis, Sonali
name: Werdan, Karl
name: Kuss, Oliver
name: Tamayo, Teresa
name: Haerting, Johannes
name: Greiser, Karin Halina
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2016
Subjects: subject: EPIDEMIOLOGY
subject: PUBLIC HEALTH
subject: 610 Medizin

description: Objective: To compare the association between different anthropometric measurements and incident type 2 diabetes mellitus (T2DM) and to assess their predictive ability in different regions of Germany. Methods: Data of 10 258 participants from 4 prospective population-based cohorts were pooled to assess the association of body weight, body mass index (BMI), waist circumference (WC), waist-to-hip-ratio (WHR) and waist-to-height-ratio (WHtR) with incident T2DM by calculating HRs of the crude, adjusted and standardised markers, as well as providing receiver operator characteristic (ROC) curves. Differences between HRs and ROCs for the different anthropometric markers were calculated to compare their predictive ability. In addition, data of 3105 participants from the nationwide survey were analysed separately using the same methods to provide a nationally representative comparison. Results: Strong associations were found for each anthropometric marker and incidence of T2DM. Among the standardised anthropometric measures, we found the strongest effect on incident T2DM for WC and WHtR in the pooled sample (HR for 1 SD difference in WC 1.97, 95% CI 1.75 to 2.22, HR for WHtR 1.93, 95% CI 1.71 to 2.17 in women) and in female DEGS participants (HR for WC 2.24, 95% CI 1.91 to 2.63, HR for WHtR 2.10, 95% CI 1.81 to 2.44), whereas the strongest association in men was found for WHR among DEGS participants (HR 2.29, 95% CI 1.89 to 2.78). ROC analysis showed WHtR to be the strongest predictor for incident T2DM. Differences in HR and ROCs between the different markers confirmed WC and WHtR to be the best predictors of incident T2DM. Findings were consistent across study regions and age groups (
sj-pdf-1-ajs-10.1177_03635465211023183 – Supplemental material for Intra-articular Injection of Kartogenin-Enhanced Bone Marrow–Derived Mesenchymal Stem Cells in the Treatment of Knee Osteoarthritis in a Rat Model
Creators: name: Zeng, Wei-Nan
name: Zhang, Yun
name: Wang, Duan
name: Zeng, Yi-Ping
name: Yang, Hao
name: Li, Juan
name: Zhou, Cheng-Pei
name: Liu, Jun-Li
name: Yang, Qing-Jun
name: Deng, Zhong-Liang
name: Zhou, Zong-Ke
Publisher: name: SAGE Journals
Year: 2021
Subjects: Orthopaedics
Sports Medicine
Surgery

description: Supplemental material, sj-pdf-1-ajs-10.1177_03635465211023183 for Intra-articular Injection of Kartogenin-Enhanced Bone Marrow–Derived Mesenchymal Stem Cells in the Treatment of Knee Osteoarthritis in a Rat Model by Wei-Nan Zeng, Yun Zhang, Duan Wang, Yi-Ping Zeng, Hao Yang, Juan Li, Cheng-Pei Zhou, Jun-Li Liu, Qing-Jun Yang, Zhong-Liang Deng and Zong-Ke Zhou in The American Journal of Sports Medicine
D7.1 Assessing the determinants of labour market inclusion for vulnerable European citizens: an eco-systemic and multi-level approach
Creators: name: Vivoli, Arianna
name: BIGGERI, MARIO
name: Ciani, Federico
name: Ayllón, Sara
name: Samuel, Robin
name: Valls, Ona
Publisher: name: Zenodo
Year: 2024
Subjects: subject: Labour market
subject: vulnerable citizens

description: This working paper aims to contribute to the debate on the factors influencing both labour market participation and the employment status of citizens in the 27 EU member states plus Norway through a regional perspective. The authors address the role played by individual and contextual characteristics on labour market participation and employment, and how these two levels interact with each other.

The work is structured as follows: the Background and Conceptual Framework section summarises previous studies relevant to the research topics and introduces the theoretical basis of the study. The Methodology and Data section presents the research design, the data and the analytical specifications adopted. The Results section presents the main findings, starting with descriptive statistics, followed by an analysis of individual and contextual determinants, and concluding with a comparison of these determinants’ effects across rich and poor regions.

Authors: Arianna Vivoli, Mario Biggeri, Federico Ciani, Leonardo Grilli, Sara Ayllòn, Robin Samuels, Ona Valls Casas
FRACTIONATION AND CHARACTERIZATION OF LIGNIN STREAMS FROM GENETICALLY ENGINEERED SWITCHGRASS
Creators: name: Liu, Enshi
Publisher: name: University of Kentucky
Year: 2017
Subjects: subject: Biological Engineering
subject: Bioresource and Agricultural Engineering
subject: Biotechnology
subject: Catalysis and Reaction Engineering
subject: Microbiology
subject: FOS: Biological sciences

description: Development of biomass feedstocks with desirable traits for cost-effective conversion is one of the main focus areas in biofuels research. As suggested by techno-economic analyses, the success of a lignocellulose-based biorefinery largely relies on the utilization of lignin to generate value-added products, i.e. fuels and chemicals. The fate of lignin and its structural/compositional changes during pretreatment have received increasing attention; however, the effect of genetic modification on the fractionation, depolymerization and catalytic upgrading of lignin from genetically engineered plants is not well understood. This study aims to fractionate and characterize the lignin streams from a wild-type and two genetically engineered switchgrass (Panicum virgatum) species (low lignin content with high S/G ratio and high lignin content) using three different pretreatment methods, i.e. dilute sulfuric acid, ammonia hydroxide, and aqueous ionic liquid (cholinium lysinate). The structural and compositional features and impact of lignin modification on lignin-carbohydrate complex characteristics and the deconstruction of cell-wall compounds were investigated. Moreover, a potential way to upgrade low molecular weight lignin to lipids by Rhodococcus opacus was evaluated. Results from this study provide a better understanding of how lignin engineering of switchgrass influences lignin fractionation and upgrading during conversion processes based on different pretreatment technologies.
Does rapid HIV disease progression prior to combination antiretroviral therapy hinder optimal CD4+ T-cell recovery once HIV-1 suppression is achieved?
Creators: name: Jarrin, Inma
name: Pantazis, Nikos
name: Dalmau, Judith
name: Phillips, Andrew N.
name: Olson, Ashley
name: Mussini, Cristina
name: Boufassa, Faroudy
name: Costagliola, Dominique
name: Porter, Kholoud
name: Blanco, Juliá
name: Amo, Julia Del
name: Martinez-Picado, Javier
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2015
Subjects: subject: Humans
subject: Female
subject: Male
subject: Adult
subject: Middle Aged
subject: Young Adult
subject: Time Factors
subject: Cohort Studies
subject: CD4 Lymphocyte Count
subject: HIV Infections/drug therapy
subject: Viral Load
subject: Antiretroviral Therapy Highly Active
subject: CD4-Positive T-Lymphocytes/immunology
subject: Disease Progression
subject: Anti-Retroviral Agents/therapeutic use
subject: HIV Infections/pathology
subject: HIV-1/isolation & purification
subject: 610 Medizin

description: Objective: This article compares trends in CD4+ T-cell recovery and proportions achieving optimal restoration (≥500 cells/μl) after viral suppression following combination antiretroviral therapy (cART) initiation between rapid and nonrapid progressors. Methods: We included HIV-1 seroconverters achieving viral suppression within 6 months of cART. Rapid progressors were individuals experiencing at least one CD4+ less than 200 cells/μl within 12 months of seroconverters before cART. We used piecewise linear mixed models and logistic regression for optimal restoration. Results: Of 4024 individuals, 294 (7.3%) were classified as rapid progressors. At the same CD4+ T-cell count at cART start (baseline), rapid progressors experienced faster CD4+ T-cell increases than nonrapid progressors in first month [difference (95% confidence interval) in mean increase/month (square root scale): 1.82 (1.61; 2.04)], which reversed to slightly slower increases in months 1–18 [−0.05 (−0.06; −0.03)] and no significant differences in 18–60 months [−0.003 (−0.01; 0.01)]. Percentage achieving optimal restoration was significantly lower for rapid progressors than nonrapid progressors at months 12 (29.2 vs. 62.5%) and 36 (47.1 vs. 72.4%) but not at month 60 (70.4 vs. 71.8%). These differences disappeared after adjusting for baseline CD4+ T-cell count: odds ratio (95% confidence interval) 0.86 (0.61; 1.20), 0.90 (0.38; 2.17) and 1.56 (0.55; 4.46) at months 12, 36 and 60, respectively. Conclusion: Among people on suppressive antiretroviral therapy, rapid progressors experience faster initial increases of CD4+ T-cell counts than nonrapid progressors, but are less likely to achieve optimal restoration during the first 36 months after cART, mainly because of lower CD4+ T-cell counts at cART initiation.
sj-pdf-1-jaf-10.1177_0148558X211025250 – Supplemental material for The Trade-Off Between Mandatory and Voluntary Disclosure: Evidence From Oil Companies’ Risk Reporting
Creators: name: Arena, Claudia
name: Bozzolan, Saverio
name: Imperatore, Claudia
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business

description: Supplemental material, sj-pdf-1-jaf-10.1177_0148558X211025250 for The Trade-Off Between Mandatory and Voluntary Disclosure: Evidence From Oil Companies’ Risk Reporting by Claudia Arena, Saverio Bozzolan and Claudia Imperatore in Journal of Accounting, Auditing & Finance
Additional file 1 of Effect and potential mechanism of oncometabolite succinate promotes distant metastasis of colorectal cancer by activating STAT3
Creators: name: Yu, Jiangnan
name: Yang, Hong
name: Zhang, Lin
name: Ran, Suye
name: Shi, Qing
name: Peng, Pailan
name: Liu, Qi
name: Song, Lingyu
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Science Policy
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Supplementary Material 1
Joan Maragall secondo Giuseppe Grilli
Creators: name: Ardolino, Francesco
Publisher: name: Edizioni Ca' Foscari
Year: 2016
Subjects: subject: Catalan literature

description: Grilli's interpretation of Joan Maragall – the poet who has been purported to be a symbol of Catalan Modernism – is a kaleidoscopic study of literature, art and music. Nonetheless, it maintains an internal coherence over the course of the Grilli's critical reading and thinking. His maragallian analysis are organized in three points: the Montale's translations of the «Cant Espiritual»; the vision
of a reloaded mythology in an urban dimension (Count Arnau) and, finally, the shrinkage of the Odissean character's value in
Nausica
Intestinal Cell Tight Junctions Limit Invasion of Candida albicans through Active Penetration and Endocytosis in the Early Stages of the Interaction of the Fungus with the Intestinal Barrier
Creators: name: Goyer, Marianne
name: Loiselet, Alicia
name: Bon, Fabienne
name: L’Ollivier, Coralie
name: Laue, Michael
name: Holland, Gudrun
name: Bonnin, Alain
name: Dalle, Frederic
Publisher: name: Robert Koch-Institut, Biologische Sicherheit
Year: 2016
Subjects: subject: Humans
subject: Intestines/microbiology
subject: Caco-2 Cells
subject: Intestines/ultrastructure
subject: Candida albicans/physiology
subject: Candidiasis/metabolism
subject: Candidiasis/microbiology
subject: Endocytosis
subject: Host-Pathogen Interactions
subject: Intestines/metabolism
subject: Tight Junctions/metabolism
subject: Tight Junctions/microbiology
subject: Tight Junctions/ultrastructure
subject: 610 Medizin

description: C. albicans is a commensal yeast of the mucous membranes in healthy humans that can also cause disseminated candidiasis, mainly originating from the digestive tract, in vulnerable patients. It is necessary to understand the cellular and molecular mechanisms of the interaction of C. albicans with enterocytes to better understand the basis of commensalism and pathogenicity of the yeast and to improve the management of disseminated candidiasis. In this study, we investigated the kinetics of tight junction (TJ) formation in parallel with the invasion of C. albicans into the Caco-2 intestinal cell line. Using invasiveness assays on Caco-2 cells displaying pharmacologically altered TJ (i.e. differentiated epithelial cells treated with EGTA or patulin), we were able to demonstrate that TJ protect enterocytes against invasion of C. albicans. Moreover, treatment with a pharmacological inhibitor of endocytosis decreased invasion of the fungus into Caco-2 cells displaying altered TJ, suggesting that facilitating access of the yeast to the basolateral side of intestinal cells promotes endocytosis of C. albicans in its hyphal form. These data were supported by SEM observations of differentiated Caco-2 cells displaying altered TJ, which highlighted membrane protrusions engulfing C. albicans hyphae. We furthermore demonstrated that Als3, a hypha-specific C. albicans invasin, facilitates internalization of the fungus by active penetration and induced endocytosis by differentiated Caco-2 cells displaying altered TJ. However, our observations failed to demonstrate binding of Als3 to E-cadherin as the trigger mechanism of endocytosis of C. albicans into differentiated Caco-2 cells displaying altered TJ.
The Abject Life of Things h.c. andersen's sentimentality
Creators: name: Adler, Anthony
Publisher: name: Humanities Commons
Year: 2017
Subjects: subject: Children's literature
subject: Philosophy, Continental
subject: Critical theory
subject: Danish literature
subject: Germanic literature

description: The following paper attempts a philosophically rigorous interpretation of H.C. Andersen’s tales. Through a radically conceived sentimentality --- the unmediated juxtaposition of the abjection of things, conceived as a paradoxical “desire for desire” having no place in the world, with a cruel, apathetic gaze --- Andersen challenges the existence of the soul or subjectivity as what, by combining the theoretical gaze with contemplative pleasure, grants coherence to experience. Thus undermining not only Romantic self-reflection, and its suturing of philosophy to criticism, but Plato’s erotic psychology, Andersen inaugurates a new philosophical literature: a writing for children cultivating an openness
THE USE OF SPEECH SYNTHESIS TECHNOLOGY IN LANGUAGE LEARNING
Creators: name: Numonova Jayrona  Gʻolibjon qizi 2nd year student of Faculty of Foreign Languages  Fergana State University
Publisher: name: Zenodo
Year: 2024

description: This article reviews the integration of speech synthesis technology, also known as text-to-speech technology, in language learning. It discusses its potential to improve pronunciation, intonation, and listening skills among learners, supported by studies demonstrating significant benefits in these areas. Employing a mixed-methods approach, the study includes quantitative assessments and qualitative insights from learners, highlighting substantial improvements in language learning outcomes for those using speech synthesis technology. Results indicate enhanced pronunciation accuracy, intonation skills, and listening comprehension compared to traditional methods. Qualitative data underscore learners' positive perceptions of personalized and interactive learning experiences with the technology. Overall, while challenges such as accuracy and naturalness of synthesized speech exist, the article concludes that speech synthesis technology offers valuable resources for language education, promoting dynamic and engaging language learning environments.

Keywords: Speech synthesis technology, text-to-speech, language learning, pronunciation, intonation, listening skills, effectiveness, quantitative analysis, qualitative exploration, mixed-methods approach, experimental design, language proficiency, personalized learning, interactive practice, pronunciation accuracy, intonation skills, listening comprehension
Additional file 2 of Effect and potential mechanism of oncometabolite succinate promotes distant metastasis of colorectal cancer by activating STAT3
Creators: name: Yu, Jiangnan
name: Yang, Hong
name: Zhang, Lin
name: Ran, Suye
name: Shi, Qing
name: Peng, Pailan
name: Liu, Qi
name: Song, Lingyu
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Science Policy
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Supplementary Material 2
Rapid outbreak sequencing of Ebola virus in Sierra Leone identifies transmission chains linked to sporadic cases
Creators: name: Arias, Armando
name: Watson, Simon J.
name: Asogun, Danny
name: Tobin, Ekaete Alice
name: Lu, Jia
name: Phan, My V. T.
name: Jah, Umaru
name: Wadoum, Raoul Emeric Guetiya
name: Meredith, Luke
name: Caddy, Lucy Thorne Sarah
name: Tarawalie, Alimamy
name: Langat, Pinky
name: Dudas, Gytis
name: Faria, Nuno R.
name: Dellicour, Simon
name: Kamara, Abdul
name: Kargbo, Brima
name: Kamara, Brima Osaio
name: Gevao, Sahr
name: Cooper, Daniel
name: Newport, Matthew
name: Kurth, Andreas
name: Kellam, Paul
name: Goodfellow, Ian
name: Cotten, Matthew
Publisher: name: Robert Koch-Institut, Biologische Sicherheit
Year: 2016
Subjects: subject: transmission
subject: evolution
subject: Ebola virus
subject: outbreak sequencing
subject: 610 Medizin

description: To end the largest known outbreak of Ebola virus disease (EVD) in West Africa and to prevent new transmissions, rapid epidemiological tracing of cases and contacts was required. The ability to quickly identify unknown sources and chains of transmission is key to ending the EVD epidemic and of even greater importance in the context of recent reports of Ebola virus (EBOV) persistence in survivors. Phylogenetic analysis of complete EBOV genomes can provide important information on the source of any new infection. A local deep sequencing facility was established at the Mateneh Ebola Treatment Centre in central Sierra Leone. The facility included all wetlab and computational resources to rapidly process EBOV diagnostic samples into full genome sequences. We produced 554 EBOV genomes from EVD cases across Sierra Leone. These genomes provided a detailed description of EBOV evolution and facilitated phylogenetic tracking of new EVD cases. Importantly, we show that linked genomic and epidemiological data can not only support contact tracing but also identify unconventional transmission chains involving body fluids, including semen. Rapid EBOV genome sequencing, when linked to epidemiological information and a comprehensive database of virus sequences across the outbreak, provided a powerful tool for public health epidemic control efforts.
sj-pdf-2-cmp-10.1177_07388942211026319 – Supplemental material for Fear of campaign violence and support for democracy and autocracy
Creators: name: von Borzyskowski, Inken
name: Daxecker, Ursula
name: Kuhn, Patrick M.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 220104 Human Rights and Justice Issues
subject: FOS: Philosophy, ethics and religion
subject: 160607 International Relations
subject: FOS: Political science

description: Supplemental material, sj-pdf-2-cmp-10.1177_07388942211026319 for Fear of campaign violence and support for democracy and autocracy by Inken von Borzyskowski, Ursula Daxecker and Patrick M. Kuhn in Conflict Management and Peace Science
Spectral Consciousness in Post-9/11 American Poetry
Creators: name: Chakraborty, Joydeep
Publisher: name: Humanities Commons
Year: 2017
Subjects: subject: American literature
subject: United States
subject: Area studies
subject: Postmodernism

description: After presenting an overview of scholarship on post-9/11 American poetry, my article focuses on a group of largely neglected post-9/11 poems, which deal with spectral consciousness and hallucinatory experiences. These poems not only challenge a number of traditional binaries like, ‘presence / absence’, ‘living /dead’, ‘synchronic / diachronic’ and so on, but also maintain in their most mature form a certain cognitive stability which lends a rich dimension to post-9/11 poetics. In examining spectral consciousness in such poems, my article also identifies interesting points of connection between postmodernism and them.
LIGHTWEIGHT MECHANICAL METAMATERIALS BASED ON HOLLOW LATTICES AND TRIPLY PERIODIC MINIMAL SURFACES
Creators: name: Deng, Biwei
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Materials engineering not elsewhere classified
Additive manufacturing

description: Lightweight mechanical metamaterials with exception specific stiffness and strength are useful in many applications, such as transportation, aerospace, architectures and etc. These materials show great potential in mechanical tasks where weight of the material is restrained due to economy or energy reasons. To achieve both the lightweight and the high specific mechanical properties, the metamaterials are often in form of periodic cellular structures with well-designed unit cells. The strategies in designing and improving such cellular structures become the key in the studies of such mechanical metamaterials. In this work, we use both experimental and numerical approaches while probing three types of mechanical metamaterials: i) composite bending dominated hollow lattices (HLs); ii) triply periodic minimal surfaces (TPMSs) and extended TPMSs (eTPMSs); iii) corrugated TPMSs. We have demonstrated a few strategies in designing and improving the specific stiffness or strength via these examples of mechanical metamaterials. Using carbon/ceramic composite in the bending dominated HLs, we prove that using the composite layered material against the single layer ceramic is effective in improving the specific mechanical performances of the mechanical metamaterials. Next, while studying the nature of TPMS, we discover that under isotropic deformation TPMSs are stretch dominated with no stress concentrations within the shell structure. They also have an optimal specific bulk modulus approaching the H-S upper bound. Furthermore, we establish a strategy to smoothly connect the zero-mean-curvature surfaces in TPMSs with the extension of zero-Gaussion-curvature surfaces, forming new ‘eTPMSs”. These new shellular structures trade off its isotropy and have improved specific Young’s modulus along their stiffest orientation compared to their TPMS base structures. Lastly, we introduce corrugated sub-structures to existing TPMSs to improve their mechanical properties, such as Young’s modulus, yield strength and failure strength in compression. It is found that the corrugated sub-structure can effectively suppress the local bending behavior and redirect crack propagation while such structures were under uniaxial compression.
sj-pdf-1-jva-10.1177_11297298211027054 – Supplemental material for CMS ESRD quality incentive program has not improved patient dialysis vascular access
Creators: name: Shah, Sapan
name: Feustel, Paul J
name: Manning, Christina E
name: Salman, Loay
Publisher: name: SAGE Journals
Year: 2021
Subjects: Cardiology

description: Supplemental material, sj-pdf-1-jva-10.1177_11297298211027054 for CMS ESRD quality incentive program has not improved patient dialysis vascular access by Sapan Shah, Paul J Feustel, Christina E Manning and Loay Salman in The Journal of Vascular Access
Analog in the Age of Digital Reproduction: Audiophilia, Semiaura and the Cultural Memory of the Phonograph
Creators: name: Adler, Anthony
Publisher: name: Fordham University Press
Year: 2012

description: "analyses the spectral presence of the phonograph within a digital omnipresence: its afterlife as a material echo of the past... Analyzing audiophilia--- basically a desire for material presence --- in the apparently disembodied age of the digital, Adler shows how the former is as it were animated as aura by the effects of the latter (infinite simulation). New media do not merely refashion or repurpose but in fact produce old media... As Adler argues, analog mediation (vinyl) becomes auratic in the Benjaminian sense of the term due to its dysfunctionality: its very limitations and imperfections that render it sens(i)bly material. This dysfunctionality only comes to the fore as a trace of a materiality in relation to the allegedly disembodied recordings and archivings on the net."
From "Introduction," Kiene Brillenburg Wurth, p. 11-12.
The utilization of colonoscopy in Germany
Creators: name: Starker, Anne
name: Buttmann-Schweiger, Nina
name: Kraywinkel, Klaus
name: Kuhnert, Ronny
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2017
Subjects: subject: GERMANY
subject: HEALTH MONITORING
subject: CANCER SCREENING
subject: COLORECTAL CANCER
subject: COLONOSCOPY
subject: 610 Medizin

description: Colorectal cancer is one of the three most common cancers in German adults. There are several legally based examinations for the early detection of colorectal cancer. People aged 50 to 54 years can have a faecal blood test annually. From the age of 55, this test is offered every two years as part of cancer screening, or alternatively a preventive colonoscopy, which can be repeated after ten years if the findings are inconspicuous. However, colonoscopies are also carried out to clarify complaints or other diseases (curative colonoscopy). In the GEDA 2014/2015-EHIS study, the respondents provided the date of their last colonoscopy. No data was collected on the reason why this colonoscopy was performed. 57% of women and 61% of men aged 55 years or older reported that they had a colonoscopy within the last 10 years. New legal regulations envisage the expansion of colorectal cancer screening and its development into an organised, quality-assured early detection programme.
Additional file 3 of Effect and potential mechanism of oncometabolite succinate promotes distant metastasis of colorectal cancer by activating STAT3
Creators: name: Yu, Jiangnan
name: Yang, Hong
name: Zhang, Lin
name: Ran, Suye
name: Shi, Qing
name: Peng, Pailan
name: Liu, Qi
name: Song, Lingyu
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Science Policy
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Supplementary Material 3
Supplemental Material, sj-docx-1-spp-10.1177_19485506211025909 - Anger and Sadness as Moral Signals
Creators: name: Plaks, Jason E.
name: Robinson, Jeffrey S.
name: Forbes, Rachel
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental Material, sj-docx-1-spp-10.1177_19485506211025909 for Anger and Sadness as Moral Signals by Jason E. Plaks, Jeffrey S. Robinson and Rachel Forbes in Social Psychological and Personality Science
Ideal Cities-Marred Individuals: J. M. Coetzee's The Childhood of Jesus and José Saramago's A Caverna
Creators: name: Nashef, Hania
Publisher: name: Humanities Commons
Year: 2017
Subjects: subject: Comparative literature
subject: English literature
subject: European literature
subject: Portuguese literature

description: In the final pages of J. M. Coetzee's The Childhood of Jesus and José Saramago's A Caverna, the main protagonists flee to an unknown destination from their respective "utopias." Both allegorical novels expose the ills of two guarded and structured communities. A Caverna, a parable of Plato's cave, depicts the story of the lives of 64-year-old Algor, a third-generation earthenware potter, and his family. When Algor is no longer able to sell his earthenware products, the family is forced to reside at the Center. Coetzee's novel begins with the arrival of Simón and the child David at the Spanish-speaking city of Novilla. Simón assumes guardianship of the boy. Although the concept of "utopia" is presented differently in these two novels, the place operates in the same way; both places function through a faceless controlling bureaucratic authority, claiming that the welfare of the inhabitants is its driving force. A rebirth of the human is required for surviving in the new surroundings. In this article, I would like to compare how both authorities function under the pretext of creating the ideal world, which ultimately results in safeguarding their own interests, and consequently perpetuating the sterile and anesthetized existence of their citizens.
Supplemental Material, sj-pdf-1-vet-10.1177_03009858211025791 - Epithelial lacrimal gland tumors in dogs and cats: Is the human WHO classification appropriate for animals?
Creators: name: Giudice, Chiara
name: Nordio, Laura
name: Cadonici, Micol
name: Perelli, Maria Novella
name: Caniatti, Mario
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine
subject: 70706 Veterinary Medicine
subject: FOS: Veterinary sciences

description: Supplemental Material, sj-pdf-1-vet-10.1177_03009858211025791 for Epithelial lacrimal gland tumors in dogs and cats: Is the human WHO classification appropriate for animals? by Chiara Giudice, Laura Nordio, Micol Cadonici, Maria Novella Perelli and Mario Caniatti in Veterinary Pathology