cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Investigation of lattice dynamics, magnetism and electronic transport in $β$-Na$_{0.33}$V$_2$O$_{5}$
Creators: name: Shukla, Rishabh
name: Ulrich, Clemens
name: Dhaka, R. S.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We investigate the electronic and magnetic properties as well as lattice dynamics and spin-phonon coupling of $β$-Na$_{0.33}$V$_2$O$_5$ using temperature-dependent Raman scattering, dc-magnetization and dc-resistivity, x-ray photoemission, and absorption spectroscopy. The Rietveld refinement of XRD pattern with space group C2/m confirms the monoclinic structure. The analysis of temperature-dependent Raman spectra in a temperature range of 13--673~K reveals an anharmonic dependence of the phonon frequency and full width at half maximum, which is accredited to the symmetric phonon decay. However, below about 40 K, the hardening of the phonon frequency beyond anharmonicity is attributed to the spin-phonon coupling. Interestingly, the estimated effective magnetic moment $μ_{\rm eff}=$ 0.63~$μ_B$ from the magnetization data manifests a mixed-valence state of V ions in 4+ (18$\pm$1\%) and 5+ (82$\pm$1\%). A similar ratio of V$^{4+}$ to V$^{5+}$ is also observed in the x-ray photoemission and x-ray absorption near-edge spectra and that is found to be consistent with the sample stoichiometry. In addition, the V$^{4+}$ ions are distributed between different vanadium (V1 and V3) sites. The analysis of extended x-ray absorption fine structure at different V-sites gives the corresponding V--O bond lengths, which are utilized in the assignment of Raman modes. Moreover, the temperature-dependent resistivity resembles a semiconducting behavior where the charge carrier transport is facilitated by the band conduction at higher temperatures and via hopping $\le$260~K.
description: to be published in PRB
The local regularity theory for the Navier-Stokes Equations Near the Boundary
Creators: name: Seregin, Gregory
name: Shilkin, Timofey
Publisher: name: arXiv
Year: 2014
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: This is an expository paper on the theory of local regularity for weak solutions to the non-stationary 3D Navier-Stokes equations near the boundary of a domain.
АНАЛИЗ ФАКТОРОВ, ВЛИЯЮЩИХ НА ПРИБЫЛЬ ПРЕДПРИЯТИЯ
Creators: name: Романовская Елена Вадимовна
name: Семахин Евгений Александрович
name: Захарова Анастасия Владимировна
name: Закунова Екатерина Дмитриевна
Publisher: name: Московский экономический журнал
Year: 2020
Subjects: РЕНТАБЕЛЬНОСТЬ
ФИНАНСОВЫЕ РЕЗУЛЬТАТЫ
ТЕХНИЧЕСКИЙ ПРОГРЕСС
ФАКТОРЫ
ЭНЕРГОСБЕРЕЖЕНИЕ
PROFITABILITY
FINANCIAL RESULTS
TECHNICAL PROGRESS
FACTORS
ENERGY SAVING

description: В статье проведён анализ отдельных характеристик финансовых результатов предприятий промышленности в России, исследованы факторы, оказывающие большое влияние на них, установлены главные направления повышения производительности финансово-хозяйственной деятельности. В статье представлена оценка финансовых результатов деятельности российских предприятий в современных условиях и определены пути выявления резервов их роста, в том числе с помощью финансового анализа
SU(2) Lattice Gluon Propagator and Potential Models
Creators: name: Serenone, Willian M.
name: Cucchieri, Attilio
name: Mendes, Tereza
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the bottomonium spectrum using a potential model. Our potential incorporates lattice results for the gluon propagator, obtained from simulations of pure SU(2) gauge theory in Landau gauge. The mass of the bottom quark is left as a free parameter. The resulting spectrum is compared to the case of the Coulomb plus Linear (or Cornell) Potential.
description: 8 pages, 4 figures, presented at the 31st International Symposium on Lattice Field Theory (Lattice 2013), 29 July - 3 August 2013, Mainz, Germany
Spin-Photon Interaction in a Cavity with Time-Reversal Symmetry Breaking
Creators: name: Goryachev, Maxim
name: Farr, Warrick G.
name: Creedon, Daniel L.
name: Tobar, Michael E.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Employing a sapphire whispering gallery mode resonator, we demonstrate features of the spin-photon interaction in cavities with broken time-reflection symmetry. The broken symmetry leads to a lifting of the degeneracy between left-handed and right-handed polarised cavity photons, which results in an observable gyrotropic effect. In the high-$Q$ cavity limit, such a situation requires a modification of the Tavis-Cummings Hamiltonian to take into account conservation of spin angular momentum and the corresponding selection rules. As a result, the system is represented by a system of two linearly coupled bosonic modes, with each one coupled to its own sub-ensemble of two-level systems with different energy splittings. In the experimental example, these sub-ensembles originate from Fe$^{3+}$ impurity ions effectively seen as a two level systems at the interaction frequency. The temperature dependence of the population of each sub-ensemble (in terms of effective susceptibility of the medium) is determined experimentally in accordance with the theoretical predictions revealing various paramagnetic impurity types in the solid. The regimes of backscatterer and spin ensemble domination are discussed and compared.
description: Phys. Rev. B, 2014
Uncovering the Hidden Proteome of Streptococcus pneumoniae D39
Creators: name: Laczkovich, Irina
Publisher: name: University of Illinois at Chicago
Year: 2023
Subjects: Uncategorized

description: Microproteins encoded in small open reading frames (sORFs), of less than 50 amino acids, are increasingly recognized as vital components of metabolic pathways, regulatory functions, and virulence. Despite their biological importance, their discovery in Gram-positive pathogens remains limited due to the difficulty of their annotation. Conventional computational algorithms lack the accuracy to predict true protein coding sORFs among many false predictions. Here we present a refined approach to identify actively translated sORFs utilizing two translation initiation inhibitors, retapamulin and lefamulin, in combination with ribosome profiling using the model organisms Streptococcus pneumoniae D39 and Streptococcus pyogenes M1T1 5448. We identified 114 novel sORFs in S. pneumoniae and 120 sORFs in S. pyogenes of which a subset was validated experimentally. In S. pneumoniae, two loci associated with virulence and quorum sensing were examined in deeper details. One such sORF, rio03, overlaps with the noncoding RNA srf-02 that was previously implicated in pathogenesis. Targeted mutagenesis parsing rio03 from srf-02 revealed that rio03 is responsible for the fitness defect seen in a murine nasopharyngeal colonization model. Additionally, two novel sORFs located adjacent to the quorum sensing receptor rgg1518 were found to impact regulatory activity. Our findings emphasize the importance of sORFs present in genomes of pathogenic bacteria and underscore the utility of ribosome profiling for identifying the bacterial translatome.
СОВРЕМЕННЫЕ МЕТОДЫ ОЦЕНКИ КАНДИДАТОВ ПРИ ПОДБОРЕ ПЕРСОНАЛА
Creators: name: Тихонов Алексей Иванович
Publisher: name: Московский экономический журнал
Year: 2020
Subjects: УПРАВЛЕНИЕ ПЕРСОНАЛОМ
ОЦЕНКА КАНДИДАТОВ
РЕКРУТМЕНТ
ПОДБОР ПЕРСОНАЛА
HUMAN RESOURCE MANAGEMENT
CANDIDATE ASSESSMENT
RECRUITMENT
PERSONNEL SELECTION

description: В статье рассмотрены различные методы оценки кандидатов при найме персонала на российском рынке труда. Методы оценки разделены на два класса стандартные и нестандартные. Стандартные применяются значительным числом работодателей для большинства категорий персонала и привычны для соискателей. Нестандартные используются в отдельных случаях, применяются в основном для найма определенных категорий персонала и могут вызывать неоднозначное отношение со стороны соискателей. В статье рассматривается популярность использования различных методов оценки на российском рынке труда. Рассмотрена относительная частота использования стандартных методов оценки кандидатов в компаниях на российском рынке. Также рассмотрена частота использования стандартных методов оценки кандидатов и частота их использования для найма специалистов из различных профессиональных областей на российском рынке труда. Рассмотрено отношение работодателей к стандартным методам оценки кандидатов, в частности, рассматривается оценка работодателями положительных и негативных качеств стандартных способов оценки с точки зрения влияния на подбор персонала. Рассмотрена частота участия соискателей в стандартных собеседованиях, а также их отношение к различным формам таких собеседований в зависимости от их профессиональной принадлежности. На основании рассматриваемых данных делается вывод о характере использования стандартных инструментов оценки кандидатов на российском рынке труда и возможном изменении инструментария в будущем.
ПОДХОД К АНАЛИЗУ МАРКЕТИНГОВОГО ПОТЕНЦИАЛА СОВРЕМЕННОГО ПРЕДПРИЯТИЯ
Creators: name: Романовская Елена Вадимовна
name: Андряшина Наталия Сергеевна
name: Кугаколова Алина Олеговна
name: Анисимова Анастасия Евгеньевна
Publisher: name: Московский экономический журнал
Year: 2020
Subjects: МАРКЕТИНГОВЫЙ ПОТЕНЦИАЛ
МАРКЕТИНГОВАЯ СТРАТЕГИЯ
КОНКУРЕНТОСПОСОБНОСТЬ ПРЕДПРИЯТИЯ
ПЕРСОНАЛ
МАРКЕТИНГОВАЯ КОМПЕТЕНЦИЯ
MARKETING POTENTIAL
MARKETING STRATEGY
ENTERPRISE COMPETITIVENESS
STAFF
MARKETING COMPETENCY

description: На сегодняшний день, рыночная доля предприятия определяется конкурентными преимуществами, созданными за счет маркетингового потенциала. Сущность современного маркетинга описывается как сложное социально-экономическое явление, претерпевшее значительные изменения в ходе его трансформации от продажи продукции до мероприятий, направленных на создание и поддержание системы взаимоотношений с клиентами с целью соответствия их требованиям к товарам и услугам. Современная маркетинговая стратегия основана на отношениях доверия и сотрудничества к производителю, основанных на системе общечеловеческих ценностей.
Wetzel, Hofgerichts-Advocat
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1826

description: Ort: Freiburg i. Br.
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Structural and Functional Connectivity Across Age in a Mouse Model of Alzheimer’s Disease
Creators: name: Morrissey, Zachery
Publisher: name: University of Illinois at Chicago
Year: 2023
Subjects: Uncategorized

description: Alzheimer’s disease (AD) is the most common form of dementia. Most AD patients, however, have a sporadic form of AD, making it challenging to understand the early pathological development of the disease before cognitive impairment. To address this, a combination of in vivo magnetic resonance imaging (MRI), computational neuroimaging, and molecular biology was performed in the App NL-G-F/NL-G-F knock-in (APPKI) mouse model of AD, which harbors three familial AD mutations in the amyloid precursor protein (App) gene. The structural and functional connectivity of the brain was measured in early, middle, and late age using diffusion tensor imaging (DTI) and resting-state functional MRI (rs-fMRI), respectively. First, using DTI, APPKI had reduced fractional anisotropy, a proxy of microstructural integrity, between middle and late age compared to wild-type (WT) mice. In middle age, before changes in DTI, APPKI mice showed increased number of oligodendrocytes, but reduced lipid content, suggesting that there may be an impairment in myelin homeostasis and repair mechanisms. Second, the functional connectivity (FC) of the hippocampus was analyzed using rs-fMRI. While interhemispheric FC generally increased with age, in APPKI mice, interhemispheric FC was higher in early age, but lower after middle age, compared to WT mice. Conversely, intrahemispheric FC generally decreased across age, but with reduced laterality in APPKI mice compared to WT mice, where WT mice showed increased FC in the right hemisphere relative to the left. Finally, the FC gradient of the hippocampus was analyzed using the rest2vec graph embedding method. In early and middle age, the left–right gradient was dominant, suggesting that the hemispheres were more functionally segregated. However, in late age, the gradient shifted from left–right to anterior–posterior, suggesting that the anterior and posterior aspects of the hippocampus were more functionally segregated. These results suggest that AD pathology alters both brain structural integrity, oligodendrocyte populations, and myelin, as well as functional connectivity in the hippocampus. Taken together, these findings help to give better insight into the basic progression of AD pathology, as well as provide potential biomarkers for the development of therapeutic strategies.
Dark-siren Cosmology with Decihertz Gravitational-wave Detectors
Creators: name: Liu, Muxin
name: Liu, Chang
name: Hu, Yi-Ming
name: Shao, Lijing
name: Kang, Yacheng
Publisher: name: arXiv
Year: 2022
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Gravitational waves (GWs) originated from mergers of stellar-mass binary black holes (SBBHs) are considered as dark sirens in cosmology since they usually do not have electromagnetic counterparts. In order to study cosmos with these events, we not only need the luminosity distances extracted from GW signals, but also require the redshift information of sources via, say, matching GW sky localization with galaxy catalogs. Based on such a methodology, we explore how well decihertz GW detectors, DO-Optimal and DECIGO, can constrain cosmological parameters. Using Monte-Carlo simulated dark sirens, we find that DO-Optimal can constrain the Hubble parameter to ${σ_{H_0}} / {H_0}\, \lesssim 0.23\%$ when estimating $H_0$ alone, while DECIGO performs better by a factor of 5 with ${σ_{H_0}} / {H_0}\lesssim 0.043\%$. Such a good precision of $H_0$ will shed light on the $H_0$ tension. For multiple-parameter estimation, DECIGO can still reach a level of relative uncertainty smaller than $7\%$. The reason why decihertz detectors perform well is explained by their large numbers of SBBH GW events with good distance and angular resolution.
description: 14 pages, 8 figures, update to match published version
ИСТОРИКО - ПОЛИТИЧЕСКИЙ ПОРТРЕТ КАК МЕТОД МЕЖДИСЦИПЛИНАРНОГО ИССЛЕДОВАНИЯ
Creators: name: Игнатов В. В.
Publisher: name: Московский экономический журнал
Year: 2020
Subjects: НАУЧНЫЙ МЕТОД
МЕТОДОЛОГИЯ ИСТОРИИ
ФИЛОСОФИЯ НАУКИ
МЕЖДИСЦИПЛИНАРНЫЕ МЕТОДЫ
СОВРЕМЕННЫЙ ПОДХОД
SCIENTIFIC METHOD
METHODOLOGY OF HISTORY
PHILOSOPHY OF SCIENCE
INTERDISCIPLINARY METHODS
MODERN APPROACH

description: Данная научная статья является теоретическим осмыслением междисциплинарного подхода в исторических и политических исследованиях. Анализируя современные тенденции в развитии методологии гуманитарных наук, автор настоящей статьи обосновывает возможность применения историко-политического портрета как метода междисциплинарного исследования.
High Resolution Observations of Chromospheric Jets in Sunspot Umbra
Creators: name: Yurchyshyn, V.
name: Abramenko, V.
name: Kosovichev, S.
name: Goode, P.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Recent observations of sunspot's umbra suggested that it may be finely structured at a sub-arcsecond scale representing a mix of hot and cool plasma elements. In this study we report the first detailed observations of the umbral spikes, which are cool jet-like structures seen in the chromosphere of an umbra. The spikes are cone-shaped features with a typical height of 0.5-1.0 Mm and a width of about 0.1 Mm. Their life time ranges from 2 to 3 min and they tend to re-appear at the same location. The spikes are not associated with photospheric umbral dots and they rather tend to occur above darkest parts of the umbra, where magnetic fields are strongest. The spikes exhibit up and down oscillatory motions and their spectral evolution suggests that they might be driven by upward propagating shocks generated by photospheric oscillations. It is worth noting that triggering of the running penumbral waves seems to occur during the interval when the spikes reach their maximum height.
Estimates of solutions to the perturbed Stokes system
Creators: name: Vyalov, Viktor
name: Shilkin, Timofey
Publisher: name: arXiv
Year: 2014
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: In this paper we derive local estimates of solutions of the Perturbed Stokes system. This system arises as a reduction of the Stokes system near a curved part of the boundary of the domain if one applies a diffeomorphism flatting the boundary. The estimates obtained in the paper play the crucial role in the investigation of partial regularity of weak solutions to the Navier-Stokes system near a curved part of the boundary of the domain.
МЕДИАПЛАНИРОВАНИЕ В МАРКЕТИНГОВОЙ ДЕЯТЕЛЬНОСТИ ГОСТИНИЦЫ
Creators: name: Лебедева Татьяна Евгеньевна
name: Прохорова Мария Петровна
name: Цапина Татьяна Николаевна
Publisher: name: Московский экономический журнал
Year: 2020
Subjects: МАРКЕТИНГОВАЯ ДЕЯТЕЛЬНОСТЬ
МЕДИАПЛАНИРОВАНИЕ
РЕКЛАМА
СРЕДСТВА РЕКЛАМЫ
ГОСТИНИЦА
MARKETING ACTIVITIES
MEDIA PLANNING
ADVERTISING
ADVERTISING MEDIA
HOTEL

description: В статье авторами рассматривается актуальность и необходимость разработки медиа-плана для продвижения услуг гостиницей. Раскрываются этапы эволюции медиапланирования. Медиапланирование предполагает выбор оптимальных каналов размещения рекламы (СМИ, mass-media) для достижения максимальной эффективности рекламной кампании. Объектом исследования в статье является гостиничное предприятие ООО «Х». В результате изучения маркетинговой деятельности предприятия, в частности его рекламной деятельности выявлено ряд недостатков. Доказано, что эффективным средством формирования качественной рекламной политики является создание детального медиа-плана.
СТАНОВЛЕНИЕ И РАЗВИТИЕ НЕФТЕПЕРЕРАБАТЫВАЮЩЕЙ ПРОМЫШЛЕННОСТИ В НИЖЕГОРОДСКОЙ ОБЛАСТИ И РОССИИ
Creators: name: Кузнецов Виктор Павлович
name: Романовская Елена Вадимовна
name: Шабаров Александр Александрович
Publisher: name: Московский экономический журнал
Year: 2020
Subjects: НЕФТЕПЕРЕРАБАТЫВАЮЩАЯ ПРОМЫШЛЕННОСТЬ
ТЕХНОЛОГИЯ ПЕРЕРАБОТКИ СЫРОЙ НЕФТИ
ТЕМНЫЕ И СВЕТЛЫЕ НЕФТЕПРОДУКТЫ
НЕФТЕПЕРЕРАБАТЫВАЮЩИЕ ЗАВОДЫ
ПЕРСПЕКТИВЫ НЕФТЕПЕРЕРАБАТЫВАЮЩЕЙ ОТРАСЛИ
OIL REFINING INDUSTRY
TECHNOLOGY OF CRUDE OIL PROCESSING
DARK AND LIGHT OIL PRODUCTS
OIL REFINERIES
PROSPECTS OF THE OIL REFINING INDUSTRY

description: В статье рассматриваются важнейшие этапы становления, а также основные направления и перспективы развития нефтеперерабатывающей промышленности в РФ и в Нижегородской области. Проведен анализ структуры и динамики производства продуктов нефтепереработки. Рассмотрены проблемы, которые требуют незамедлительного решения. Обусловлены пути решения поставленных проблем.
Zimmerlin, Preiswerk, Wwe
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1826

description: Ort: Hegenheim
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
РАЗРАБОТКА ПРОЕКТА ТЕХНОЛОГИЧЕСКОГО ПЕРЕВООРУЖЕНИЯ ПРОИЗВОДСТВА НА ПРОМЫШЛЕННОМ ПРЕДПРИЯТИИ
Creators: name: Цымбалов Сергей Дмитриевич
name: Романовская Елена Вадимовна
name: Синцов Эдуард Владимирович
name: Бакулина Наталья Александровна
Publisher: name: Московский экономический журнал
Year: 2020
Subjects: ПРЕДПРИЯТИЕ
МАШИНОСТРОЕНИЕ
ПЛАНИРОВАНИЕ
ТЕХНОЛОГИЯ
ПЕРЕВООРУЖЕНИЕ
ENTERPRISE
ENGINEERING
PLANNING
TECHNOLOGY
RE-EQUIPMENT

description: При практическом исследовании была рассмотрена деятельность предприятия ООО «Технология Про». Для повышения уровня использования производственных мощностей авторами предложено пересмотреть имеющийся парк оборудования. В связи с этим предложено рассмотреть целесообразность приобретения компанией ООО «Технология Про» станка лазерной резки листового металла. Авторами приведены источники финансирования и необходимый объем финансовых ресурсов для реализации финансового проекта. В статье представлены результаты расчетов экономической оценки внедряемого проекта. Сделан вывод, что технологическое перевооружение в условиях сложного промышленного производства повысит эффективность деятельности предприятия ООО «Технология Про», обеспечит конкурентоспособность на отраслевом рынке.
Zurhosen, L. H
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1826

description: Ort: St. Petersburg
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Kondo Effect of a Jahn-Teller Ion Vibrating in a Cubic Anharmonic Potential
Creators: name: Hotta, Takashi
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We discuss the Kondo effect in a spinless two-orbital conduction electron system coupled with anharmonic Jahn-Teller vibration by employing a numerical renormalization group technique. When a temperature $T$ is decreased, we encounter a plateau of $\log 3$ entropy due to quasi-triple degeneracy of local low-energy states, composed of vibronic ground states and the first excited state with an excitation energy of $ΔE$. Around at $T$$\approx$$ΔE$, we observe an entropy change from $\log 3$ to $\log 2$. This $\log 2$ entropy originates from the rotational degree of freedom of the vibronic state and it is eventually released due to the screening by orbital moments of conduction electrons, leading to the Kondo effect of a Jahn-Teller ion. The Kondo temperature is explained by the effective $s$-$d$ model with anisotropic exchange interactions.
description: 7 pages, 4 figures
Schaezler, Joh. Lorenz
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1826

description: Ort: Augsburg
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Investigating Protein Expression, Immunogenicity, and Protection of Modified mRNA Dengue Vaccine
Creators: name: Wollner, Clayton James
Publisher: name: University of Illinois at Chicago
Year: 2023
Subjects: Uncategorized

description: Dengue virus (DENV) is the most common vector-borne viral disease with nearly 400 million worldwide infections each year concentrated in the tropical and subtropical regions of the world. During secondary infections, humoral immune responses targeting cross-reactive, poorly- neutralizing epitopes can lead to increased infectivity of susceptible cells and more severe disease via antibody-dependent enhancement (ADE) with both infections and vaccinations capable of contributing to ADE. Currently, there are no available therapeutics to combat DENV disease, and there is an urgent need for a safe and efficacious vaccine. We developed a nucleotide- modified mRNA vaccine encoding the membrane and envelope structural proteins from DENV serotype 1 encapsulated into lipid nanoparticles (prM/E mRNA-LNP). Once delivered to cells, prM/E expression results in virus like particle production, as confirmed by electron microscopy. Vaccination of C57BL/6 mice with this DENV1 vaccine elicited robust antiviral immune responses comparable to viral infection with high neutralizing antibody titers and antiviral CD4+ and CD8+ T cells. Immunocompromised AG129 mice vaccinated with the prM/E mRNA-LNP vaccine were protected from a lethal DENV1 challenge. Vaccination with either a wild-type (WT) vaccine or a vaccine with mutations in the immunodominant fusion-loop epitope (DFL) elicited equivalent humoral and cell mediated immune responses. Neutralizing antibodies elicited by the vaccine were sufficient to protect against a lethal challenge after passive transfer of serum antibodies to unvaccinated AG129 mice. Both WT and mutant vaccine constructs demonstrated greatly reduced ADE compared to antibodies elicited from a live DENV1 viral infection. Recently, we optimized both the sequence of a construct coding DENV2 prM/E proteins as well as the production process of the mRNA, itself. Vaccination of C57BL/6 mice with this optimized DENV2 construct resulted in elevated neutralizing antibody response.
РЕШЕНИЕ ПРОБЛЕМ ВЗАИМОДЕЙСТВИЯ В СТРОИТЕЛЬНОЙ ОТРАСЛИ ЗА СЧЁТ ВНЕДРЕНИЯ ЕДИНОЙ ИНФОРМАЦИОННОЙ СИСТЕМЫ НА ОСНОВЕ РАСПРЕДЕЛЁННОЙ БАЗЫ ДАННЫХ
Creators: name: Сотников Дмитрий Олегович
Publisher: name: Московский экономический журнал
Year: 2020
Subjects: ЕДИНАЯ ИНФОРМАЦИОННАЯ СИСТЕМА
ВНЕДРЕНИЕ
ЭКОНОМИЧЕСКАЯ БЕЗОПАСНОСТЬ
UNIFIED INFORMATION SYSTEM
IMPLEMENTATION
ECONOMIC SECURITY

description: Прогресс строительной науки, технологий и техники ощутимо влияет на современный мир, на различные институты и социальные сферы: экономика, менеджмент, экология, наука, политика и другие, что, безусловно, преобразует место строительства в обществе в фактор, определяющий будущее человечества. Современные технологии становятся всё более сложными и высокотехнологическими. Как над их созданием и совершенствованием, так и над практической реализацией строительства трудится множество людей, следовательно, их взаимодействие представляет большую важность для науки. Проблемам выстраивания эффективного взаимодействия в строительной сфере с привязкой к экономической безопасности и посвящена данная работа.
STUDIO DI  FUNZIONE DI DUE VARIABILI: DIFFERENZA DI DUE QUADRATI
Creators: name: Rocco MORELLI
Publisher: name: Zenodo
Year: 2023
Subjects: STUDIO DI FUNZIONE DI DUE VARIABILI

description: Un contributo proposto a Progetto Matematica K quadro - https://www.matematika.it

Da: info.matematika
Inviato: Wednesday, February 23, 2022 11:41 PM
A: Rocco Morelli
Oggetto: Re: Proposta di alcuni Esercizi

Gentile sig. Morelli,
la ringraziamo innanzitutto per l'apprezzamento e la ringraziamo ulteriormente per il materiale che ci mette a disposizione e che inseriremo con piacere nei contenuti già esistenti.
Cordiali saluti

_________________________________
Team Progetto Matematika
www.matematika.it
 
description: Vedi anche
https://roccomorelli.blogspot.com/2022/02/studio-di-funzione-di-due-variabili.html
Physics-inspired Ising Computing with Ring Oscillator Activated p-bits
Creators: name: Aadit, Navid Anjum
name: Grimaldi, Andrea
name: Finocchio, Giovanni
name: Camsari, Kerem Y.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Hardware Architecture (cs.AR)
subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: Emerging Technologies (cs.ET)
subject: Neural and Evolutionary Computing (cs.NE)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: The nearing end of Moore's Law has been driving the development of domain-specific hardware tailored to solve a special set of problems. Along these lines, probabilistic computing with inherently stochastic building blocks (p-bits) have shown significant promise, particularly in the context of hard optimization and statistical sampling problems. p-bits have been proposed and demonstrated in different hardware substrates ranging from small-scale stochastic magnetic tunnel junctions (sMTJs) in asynchronous architectures to large-scale CMOS in synchronous architectures. Here, we design and implement a truly asynchronous and medium-scale p-computer (with $\approx$ 800 p-bits) that closely emulates the asynchronous dynamics of sMTJs in Field Programmable Gate Arrays (FPGAs). Using hard instances of the planted Ising glass problem on the Chimera lattice, we evaluate the performance of the asynchronous architecture against an ideal, synchronous design that performs parallelized (chromatic) exact Gibbs sampling. We find that despite the lack of any careful synchronization, the asynchronous design achieves parallelism with comparable algorithmic scaling in the ideal, carefully tuned and parallelized synchronous design. Our results highlight the promise of massively scaled p-computers with millions of free-running p-bits made out of nanoscale building blocks such as stochastic magnetic tunnel junctions.
description: To appear in the 22nd IEEE International Conference on Nanotechnology (IEEE-NANO 2022)
title: Phytophthora on Quercus ilex L. (holm oak)
Creators: name: Cordobado Sánchez, Tamara
Publisher: name: Julius Kühn-Institut, Bundesforschungsinstitut für Kulturpflanzen, Quedlinburg
Year: 2013

description: JKI Data Sheets Plant Pests and Diagnosis; 2013/84; 3-15
New pulse profile variability associated with a glitch of PSR J0738-4042
Creators: name: Zhou, S. Q.
name: Gügercinoğlu, E.
name: Yuan, J. P.
name: Ge, M. Y.
name: Yu, C.
name: Zhang, C. M.
name: Zhang, J.
name: Feng, Z. W.
name: Ye, C. Q.
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The close correlation observed between emission state and spin-down rate change of pulsars has many implications both for the magnetospheric physics and the neutron star interior. The middle-aged pulsar PSR J0738$-$4042, which had been observed to display variations in the pulse profile associated with its spin-down rate change due to external effects, is a remarkable example. In this study, based on the 12.5-yr combined public timing data from UTMOST and Parkes, we have detected a new emission-rotation correlation in PSR J0738$-$4042 concurrent with a glitch. A glitch that occurred at MJD 57359(5) (December 3, 2015) with $Δν/ν\sim 0.36(4)\times 10^{-9}$ is the first glitch event observed in this pulsar and is probably the underlying cause of the emission-rotation correlation. Unlike the usual post-glitch behaviours, the braking torque on the pulsar has continued to increase over 1380 d, corresponding to a significant decrease in $\ddotν$. As for changes in the pulse profile after the glitch, the relative amplitude of the leading component weakens drastically, while the middle component becomes stronger. A combined model of crustquake induced platelet movement and vortex creep response is invoked to account for this rare correlation. In this scenario, magnetospheric state-change is naturally linked to the pulsar-intrinsic processes that give rise to a glitch.
description: 13 pages, 6 figures. Accepted for publication in MNRAS. Comments Welcome
EpCAM-positive disseminated cancer cells in bone marrow impact on survival of early-stage NSCLC patients
Creators: name: Mederer, Tobias
name: Elsner, Felix
name: Robold, Tobias
name: Großer, Christian
name: Neu, Reiner
name: Ried, Michael
name: Bleicher, Sabine
name: Schamberger, Thomas
name: Blochberger, Isabell
name: Hofmann, Hans-Stefan
name: Klein, Christoph A.
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: disseminated cancer cell, metastasis, early dissemination, bone marrow, lung cancer, biomarker
subject: 610 Medizin

description: Introduction Detection of disseminated cancer cells (DCC) in bone marrow (BM) of patients with early-stage NSCLC has been associated with poor outcome. However, the phenotype, and hence relevant therapy targets, of DCCs in BM are unknown. We therefore compared a classical pan-Cytokeratin (CK) antibody for DCC detection with an anti-EpCAM antibody that may also detect more stem-like cells and tested whether assay positivity impacts on the survival of NSCLC patients. Materials and methods We prospectively collected BM aspirates from 104 non-metastasized NSCLC patients that underwent potentially curative tumor resection from 2011 to 2016 at the Department of Thoracic Surgery of the University Hospital and Hospital Barmherzige Brüder in Regensburg. DCCs were detected by staining with the pan anti-CK antibody A45-B/B3 and the anti-EpCAM antibody HEA-125. We analyzed the association between detection of DCCs and clinicopathological characteristic and patient outcome. Results CK-positive and EpCAM-positive DCCs were detected in 45.2% and 52.9% of patients, respectively. Correlation between the two markers was low and neither of them was associated with sex, age, histology, T or N classification, resection status, grading or smoking habit. No significant association with tumor specific survival (TSS) and progression-free survival (PFS) was observed in patients with CK-positive DCCs. In contrast, detection of EpCAM-positive DCCs significantly correlated with reduced PFS (P=0.017) and TSS (P=0.017) and remained an independent prognostic variable for PFS and TSS upon multivariate testing (hazard ratio: 7.506 and 3.551, respectively). Detection of EpCAM-positive DCCs was the only prognostic marker for PFS. Conclusions EpCAM-positive, but not CK-positive DCCs in BM predict reduced PFS and TSS. This finding suggests that EpCAM-positive DCCs in the BM comprise metastatic founder cells necessitating their in-depth molecular analysis for detection of novel therapy targets.
ПРИМЕНЕНИЕ МАТРИЦЫ КОМПРОМИССОВ В УПРАВЛЕНИИ ПЕРСОНАЛОМ НА ПРЕДПРИЯТИЯХ АВИАЦИОННОЙ ПРОМЫШЛЕННОСТИ
Creators: name: Акимов Алексей Александрович
name: Тихонов Алексей Иванович
Publisher: name: Московский экономический журнал
Year: 2020
Subjects: УПРАВЛЕНИЕ ПЕРСОНАЛОМ
МАТРИЦА КОМПРОМИССОВ
ПРОЕКТНЫЙ МЕНЕДЖМЕНТ
РЕКРУТМЕНТ
АВИАЦИОННАЯ ПРОМЫШЛЕННОСТЬ
HUMAN RESOURCES
COMPROMISE MATRIX
PROJECT MANAGEMENT
RECRUITMENT
AVIATION INDUSTRY

description: В статье представлено научное исследование по проблемам, с которыми сталкиваются большинство подразделений по управлению персоналом при подборе, отборе и найме новых сотрудников. Целью статьи является поиск всевозможных вариантов их решения. Исследование проводилось на примере высокотехнологичного предприятия авиационной промышленности на основе методологических подходов, включающих различные методы теоретического и практического исследований. Авторы рассматривают сложные взаимосвязи между линейными руководителями и HR-службами в процессе закрытия образовавшихся вакансий. Предлагается использовать элементы проектного менеджмента в системе управления персоналом. Используется такой эффективный организационно-экономический механизм системного анализа как матрица компромиссов.
Zuppinger, Siber & Co
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1826

description: Ort: Bergamo
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Metabolic Responses of the Vascular Endothelium to Inflammatory Injury
Creators: name: Gajwani, Priyanka
Publisher: name: University of Illinois at Chicago
Year: 2023
Subjects: Uncategorized

description: The endothelial cells that line the vasculature perform essential functions during inflammation. Through interactions with the immune system, endothelial cells can drive both the extent of inflammatory injury and the rate of recovery. Although the signaling cascades that govern these processes have been well studied, the metabolic underpinnings that drive them have not been well studied. This study examines the role of endothelial metabolism in guiding both inflammatory injury and subsequent restoration. First, we examined how endothelial metabolism is reprogrammed by inflammation. We found that in response to treatment with the inflammatory mediator TNFα, endothelial cells upregulate glycolysis through activation of the glycolysis regulatory enzyme PFKFB3. Consistent with this glycolytic activation, TNFα also lead to an increase in cellular ATP, concentrated at the cell periphery. We developed a chemo-genetic tool called RapT, which locally upregulates ATP levels at the cell periphery by inducing translocation of PFKFB3 to the cell membrane on the addition of Rapamycin. Increased peripheral ATP enhances restoration of the endothelial barrier, an important factor in determining recovery. Thus, endothelial cells upregulate restorative glycolysis to drive the repair processes. We next examined how endothelial mitochondria respond to inflammation. In both in vivo and in vitro models, we found that inflamed endothelial cells upregulate mitochondrial degradation through the mitophagy pathway. TNFα also led to the stabilization of the mitophagy inducer Pink1, suggesting that inflammation induced endothelial mitophagy is driven by the Pink1/Parkin pathway. We developed a mouse model in which Pink1 is deleted specifically in endothelial cells, by combining lysosomal delivery of Pink1 sgRNA with endothelial-specific expression of Cas9. Using this mouse model, we observed that deletion of endothelial Pink1 was remarkably protective in an endotoxin-based inflammation model. Additionally, endothelial Pink1 deletion led to a significant decrease in neutrophil infiltration and activation. In response to TNFα or the mitophagy inducer FCCP, endothelial cells released the mitochondrial protein ND6, a pro-inflammatory molecule that activates neutrophil recruitment through activation of formyl-peptide receptors. Thus, endothelial Pink1-mediated mitophagy is a pro-inflammatory process involved in enhancing the neutrophil response.
Wirtz, Johann Jacob
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1826

description: Ort: Tecknau
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Wernigh & Wunderlich
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1826

description: Ort: Frankfurt a. M.
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
A rational approach to $η$ and $η^\prime$ transition form factors
Creators: name: Escribano, Rafel
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The $η$ and $η^\prime$ transition form factors in the space-like region are analyzed at low and intermediate energies in a model-independent way through the use of rational approximants. The slope and curvature parameters of the form factors as well as their values at infinity are extracted from experimental data. The impact of these results on the mixing parameters of the $η$-$η^\prime$ system are also discussed.
description: 5 pages, 1 figure, uses PoS style. Talk presented at the XV International Conference on Hadron Spectroscopy (HADRON 13), Nara Prefectural New Public Hall, Nara (Japan), November 4-8, 2013
Transparent Serverless execution of Python multiprocessing applications
Creators: name: Arjona, Aitor
name: Finol, Gerard
name: Garcia-Lopez, Pedro
Publisher: name: arXiv
Year: 2022
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Computer and information sciences

description: Access transparency means that both local and remote resources are accessed using identical operations. With transparency, unmodified single-machine applications could run over disaggregated compute, storage, and memory resources. Hiding the complexity of distributed systems through transparency would have great benefits, like scaling-out local-parallel scientific applications over flexible disaggregated resources in the Cloud. This paper presents a performance evaluation where we assess the feasibility of access transparency over state-of-the-art Cloud disaggregated resources for Python multiprocessing applications. We have interfaced the multiprocessing module with an implementation that transparently runs processes on serverless functions and uses an in-memory data store for shared state. To evaluate transparency, we run in the Cloud four unmodified applications: Uber Research's Evolution Strategies, Baselines-AI's Proximal Policy Optimization, Pandaral.lel's dataframe, and ScikitLearn's Hyperparameter tuning. We compare execution time and scalability of the same application running over disaggregated resources using our library, with the single-machine Python multiprocessing libraries in a large VM. For equal resources, applications efficiently using message-passing abstractions achieve comparable results despite the significant overheads of remote communication. Other shared-memory intensive applications do not perform due to high remote memory latency. The results show that Python's multiprocessing library design is an enabler towards transparency: legacy applications using efficient disaggregated abstractions can transparently scale beyond VM limited resources for increased parallelism without changing the underlying code or architecture.
Salavy, Père & Fils
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1826

description: Ort: Marseille
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
ГЕНДЕРНЫЙ СОСТАВ РАБОЧЕЙ СИЛЫ В АРКТИЧЕСКОЙ ЗОНЕ РФ
Creators: name: Попова Надежда Корниловна
Publisher: name: Московский экономический журнал
Year: 2020
Subjects: РАБОЧАЯ СИЛА
ГЕНДЕРНЫЙ СОСТАВ
ТРУДОВОЙ ДОГОВОР
ОЖИДАЕМАЯ ПРОДОЛЖИТЕЛЬНОСТЬ ЖИЗНИ
ПОТРЕБНОСТЬ В РАБОТНИКАХ
ЗАНЯТОСТЬ
БЕЗРАБОТИЦА
ДЕМОГРАФИЯ
LABOR FORCE
GENDER COMPOSITION
EMPLOYMENT CONTRACT
LIFE EXPECTANCY
NEED FOR WORKERS
EMPLOYMENT
UNEMPLOYMENT
DEMOGRAPHY

description: Объект исследованиягендерный состав рабочей силы. Предмет исследования демографические и экономические процессы, формирующие гендерный состав рабочей силы в Арктической зоне РФ. Цель исследования изучение демографических и экономических процессов, влияющих на развитие гендерного состава рабочей силы. Гипотеза исследования в гендерном составе рабочей силы важен учет социальных и экономических интересов участников. В исследовании гендерного состава рабочей силы используется метод сравнительного анализа, системный подход и диалектический метод. В статистическом анализе российских данных и арктических регионов о соотношении мужчин и женщин учитывался временной период с 1995 г. по 2018 г. За 2005-2018 гг.в Арктической зоне РФ на формирование гендерного состава рабочей силы повлияли демографические и экономические процессы. Их совместная роль сводится к разнонаправленному демографическому процессу у трудоспособной части рабочей силы. Результаты представлены в виде подготовленного литературного обзора научных трудов российских и зарубежных авторов, в определении методологии и методики исследования и выводах. Научная новизна состоит в обосновании зависимости гендерного состава рабочей силы от состава и структуры экономики. Реализуемые социальные программы в пользу женщин осуществимы с учетом финансовых возможностей бюджета. В Арктике показатель ожидаемой продолжительности жизни у мужчин и женщин уступает общероссийскому показателю. Сохраняется потенциал для последующего роста. При преобладании мужчин в составе рабочей силы сохраняется их рост среди безработных. Более продолжительному периоду активной деятельности женщин способствует заключение трудовых договоров на неопределенный срок. Для России характерен положительный процесс легализации трудовых договоров. Он связан с ужесточением требований для юридических и физических лиц
The Role of Ethanol in Inherently Selective Atomic Layer Deposition and in Making Bioactive Coating
Creators: name: Saha, Soumya
Publisher: name: University of Illinois at Chicago
Year: 2023
Subjects: Uncategorized

description: The role of ethanol in inherently selective atomic layer deposition (ISALD) and in making bioactive coating is discussed in this dissertation. ISALD of zirconia on Si and not on Cu (electroplated and electroplated followed by chemical mechanical polishing) was achieved using ZyALDTM and ethanol, which was further enhanced by multi-fold by using ZMB and ethanol. A simulation based on group contribution method (GCM) was developed for the ISALD process in which the optimum chemisorption of the precursor molecules at the thermodynamic equilibrium was determined using the efficient ant colony optimization (EACO) algorithm. Multi-objective optimization was used to determine the selectivity window over the selected range of temperature by maximizing zirconia deposition on silicon while minimizing the same on copper. The chemical nature of the deposited zirconia film was amorphous by using both ZyALDTM and ZMB at 200 °C. However, it was interesting to note that the amorphous film deposited via ZMB turned crystalline within minutes of exposure to high energy electron beam during characterization using transmission electron microscopy (TEM). Under similar conditions such as that of ISALD, zirconia was found to nucleate faster on silver than on silicon which was almost the exact opposite of what was observed between silicon and copper. Even though silver and copper are present under the same group on the periodic table, silver possesses higher catalytic activity and is more resilient to air oxidation than copper, which may have caused the early nucleation of the ALD film. Use of ethanol as the precursor co-reactant further enabled the room-temperature ALD of magnesium oxide on temperature-sensitive substrate collagen. The literature review conducted on Mg alloy-based biomedical implants indicated that rapid corrosion of magnesium may cause inflammation in the host body along with other health complications such as bacterial invasion at the wound site. Non-uniform microstructure, presence of secondary phases and higher grain size in the Mg alloys were identified to be the key factors that caused accelerated corrosion. ALD is a pristine coating technique that can deposit uniform, conformal, pin-hole free metal and metal oxide films even on organic substrates that usually have higher surface roughness. The magnesium oxide coating on collagen was also shown to be amorphous throughout the deposited layer and free from any secondary phases. Early results from the in vitro and in vivo studies performed in Brazil indicate the MgO-coated collagen membranes possess superior antibacterial properties and promote bone growth in rats along with osteoconductive properties.