cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Expression analysis of key genes for the synthesis of Astragalus membranaceus saponins and flavonoids
Creators: name: 段利强
Publisher: name: CNGB
Year: 2023
Subjects: Raw sequence reads
Assembly
Transcriptome or Gene expression
Other
de novo RNAseq dataset
Agricultural

description: [Objective] Astragalus membranaceus is a traditional Chinese herb for both medicine and food, and its main active ingredients include saponins, flavonoids, polysaccharides and so on. In this paper, we mainly explored the related species of Astragalus membranaceus, and explored the expression profiles of the synthesis of saponins and flavonoids of Astragalus membranaceus in different years. [Methods] Astragalus membranaceus was studied by high-throughput transcriptomics technology. First, Trinity was used to splice the transcriptome data of Astragalus membranaceus samples and identify unigenes. We used the species library to construct a phylogenetic tree to identify the related species of Astragalus membranaceus. The expression of unigenes was quantified by RSEM, and the gene function annotation of gene expression profiles was performed by KEGG and GSEA analysis to identify the key genes in Astragalus membranaceus for the synthesis of saponins and flavonoids, and finally the relevant key genes were verified by RT-qPCR. We defined the expression levels of key genes for the synthesis of saponins and flavonoids in different growth years of Astragalus membranaceus. [Results] A close relative species of Astragalus membranaceus is chickpeas. GSEA analysis showed that the key genes for saponin synthesis in Astragalus membranaceus were Unigene003373 and Unigene0040532, and the key genes for flavonoid synthesis were Unigene0076081 and Unigene0027187, and the expression of these four genes was significantly higher in four-year-old Astragalus membranaceus than in annual. [Conclusion]With the growth of Astragalus membranaceus, Unigene0003373, Unigene040532, Unigene0076081 and Unigene0027187 play a key role in the synthesis of saponins and flavonoids, which lay a theoretical foundation for optimizing the cultivation scheme.
Discrimination between two mechanisms of surface-scattering in a single-mode waveguide
Creators: name: Rendón, Manuel
name: Izrailev, Felix M.
name: Makarov, Nykolay M.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Transport properties of a single-mode waveguide with rough boundary are studied by discrimination between two mechanisms of surface scattering, the amplitude and square-gradient ones. Although these mechanisms are generically mixed, we show that for some profiles they can separately operate within non-overlapping intervals of wave numbers of scattering waves. This effect may be important in realistic situations due to inevitable long-range correlations in scattering profiles.
description: 5 pages, 3 figures
Typologizing Temporality: Time‐Aggregated and Time‐Patterned Approaches to Conceptualizing Homelessness
Creators: name: McAllister, William
name: Kuang, Li
name: Lennon, Mary Clare
Publisher: name: Columbia University
Year: 2010
Subjects: Social sciences--Research

description: This article employs a relatively new method to construct time‐based typologies of homelessness, arguing that time‐aggregated typologies in previous research lose useful information by summing, averaging, or otherwise summarizing events that occur over time. This study instead proposes a time‐patterned approach that measures the timing, duration, and sequence of events as they unfurl over time. It first compares the two approaches by examining support for a theorized three‐category typology analyzed by Randall Kuhn and Dennis Culhane. Both approaches identify the three groups initially found by Kuhn and Culhane, but the time‐patterned approach performs marginally better. Both analyses leave too much heterogeneity in the groups, and the initial theory for the three categories is not robust. These deficiencies suggest the utility of further analysis. Using a time‐patterned analysis, this study then identifies 10 temporally based homeless groups that strongly differ from the three groups found by Kuhn and Culhane. It then organizes these 10 groups into four sets of groups and speculates about how structural factors and individual traits can combine to generate these categories.
Enhancement of the $ν= 5/2$ Fractional Quantum Hall State in a Small In-Plane Magnetic Field
Creators: name: Liu, Guangtong
name: Zhang, Chi
name: Tsui, D. C.
name: Knez, Ivan
name: Levine, Aaron
name: Du, R. R.
name: Pfeiffer, L. N.
name: West, K. W.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Using a 50-nm width, ultra-clean GaAs/AlGaAs quantum well, we have studied the Landau level filling factor $ν= 5/2$ fractional quantum Hall effect in a perpendicular magnetic field $B \sim$ 1.7 T and determined its dependence on tilted magnetic fields. Contrary to all previous results, the 5/2 resistance minimum and the Hall plateau are found to strengthen continuously under an increasing tilt angle $0 < θ< 25^\circ$ (corresponding to an in-plane magnetic field 0 $ 60^\circ$, and the composite fermion series [2+$p/(2p\pm1)$], $p =$ 1, 2 can be identified. Based on our results, we discuss the relevance of a Skyrmion spin texture at $ν= 5/2$ associated with small Zeeman energy in wide quantum wells, as proposed by W$\acute{\text o}$js $et$ $al$., Phys. Rev. Lett. 104, 086801 (2010).
description: 5+ pages, 3 figures, accepted for by Phy. Rev. Lett
Expensive drugs for rare diseases : an anthropological analysis of the cultural, political, and economic dimensions of metabolic disease
Creators: name: McGuire, Marlene
Publisher: name: University of British Columbia
Year: 2012

description: In the context of Canada’s publicly funded universal health care system, access to potentially life-saving and/or life lengthening orphan drugs costing anywhere from $100,000.00 to $850,000.00 per patient per year is a complicated matter. This study is an anthropological examination of the debates surrounding ‘expensive drugs for rare diseases’, a term that has come to represent the costly treatments developed for rare metabolic diseases like Mucopolysaccharidosis, Pompe Disease, Fabry Disease, and Phenylketonuria. This study was conducted in British Columbia, Canada. It is based on several months of participant observation in hospital, industry, and patient advocacy contexts, as well as 14 semi-structured interviews conducted with the different stakeholders in the debate: patients and families, health care professionals, representatives of the provincial government’s Ministry of Health, pharmaceutical companies, and patient advocacy groups. This study looks at discussions of authority, responsibility, and rights to health care/health technology. It examines how complex systems of relationships shape these discussions in a particular time and place, and how the competing cultural models of publicly funded health care and profit-based pharmaceutical policy and industry operate in the context of extremely expensive drugs. The body of literature on orphan drugs in the social sciences/humanities is very underdeveloped, and there are no known comprehensive social scientific/ethnographic studies of the metaphors, constructs, and cultural context of debates surrounding orphan drugs/expensive drugs for rare diseases. This study attempts to fill some of these gaps by looking at the complexities of different stakeholder arguments and their structural and discursive context. In attempting to reconcile and solve the problems of accessibility to EDRD, the different stakeholders directly implicated in the debate mobilize culturally shaped notions evidence, accountability, fairness, and responsibility. This study demonstrates that the problems, pitfalls, and provisional solutions articulated by the different people implicated in this debate throw in to relief the many contradictions between orphan drug policies, neglected diseases, drug regulation/assessment practices, and the relationship between pharmaceuticals and society. These frameworks and competing cultural models are creating tensions that may be irreconcilable with a publicly funded health care system.
Orchestrator design, service programming and machine learning models ((D4.1)
Creators: name: Khalili, Hazmeh
name: Papageorgiou
name: Siddiqui, Shuaib
name: Barrera, Julio
name: Huici, Felipe
name: Yasukata, Kenichi
name: Ciulli, Nicola
name: Cruschelli, Paolo
name: Kraja, Elian
name: Francesconi, Elio
name: Preto, Ricardo
name: Albanese, Antonino
name: Costa, Viscardo
name: Colman, Carlos
name: Baldoni, Gabrielle
name: Sechkova, Teodora
name: Paolino, Michele
Publisher: name: Zenodo
Year: 2019
Subjects: 5g
Orchestrator

description: This document describes the components of the 5GCity architecture related to orchestration, service programming, and machine learning as main outcomes of tasks T4.1, T4.2, and T4.3. The overall 5GCity architecture is described in Deliverable D2.2 [1] and based on pilot requirements introduced in Deliverable D2.1 [2]. Our orchestration, service programming, and machine learning components are vital for addressing challenges of state-of-the-art 5G orchestrators and platforms, such as multi-tenancy support and efficient configuration and resource placement.
Formative Study to Develop the Eban Treatment and Comparison Interventions for Couples
Creators: name: NIMH Multisite HIV/STD Prevention Trial For African American Couples Group
Publisher: name: Columbia University
Year: 2008
Subjects: subject: Psychology
subject: FOS: Psychology
subject: Public health

description: Objective: To describe formative and pilot-testing research that generated themes and procedures, curricula, and critical measures for a randomized clinical trial testing a Risk Reduction Intervention for HIV-serodiscordant African American couples (Project Eban). Design: This paper describes the themes that emerged from discussions with African American serodiscordant couples about HIV-related risks from focus groups with 11 couples and pilot study results with 32 couples across four sites. Methods: In Step 1, focus groups examined the need for a Risk Reduction Intervention for HIV-serodiscordant African American couples and confirmed four themes that formed the basis for the intervention curriculum and study format. In Step 2, a pilot study refined the clinical trial procedures for this population and tested critical measures and selected portions of the curriculum for both the treatment and comparison interventions. Results: Based on these findings, stigma and psychological distress, barriers to condom use, insufficient support from community and service organizations, and the lack of skills that emphasize individual and relationship protection were ultimately integrated into the Risk Reduction Intervention. Conclusion: Pilot study findings highlighted the importance of examining gender and ethnicity in HIV- impacted couples along with factors that heightened HIV-related risk behaviors that affect couples’ skills and psychological adjustment. The goal was to ensure that a skill-based, culturally congruent, relationship-centered intervention could be understood and of interest to couples. Future analyses in the main trial will be discussed.
Characteristics of ion-acoustic solitary wave in a laboratory dusty plasma under the influence of ion-beam
Creators: name: Deka, M. K.
name: Adhikary, N. C.
name: Misra, A. P.
name: Bailung, H.
name: Nakamura, Y.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: We study the influence of ion beam and charged dust impurity on the propagation of dust ion-acoustic (DIA) solitary wave (SW) in an unmagnetized plasma consisting of Boltzmann distributed electrons, positive ions, positive ion beam and negatively charged immobile dusts in a double plasma device. On interacting with an ion beam, the solitary wave is bifurcated into a compressive fast and a rarefactive slow beam mode, and appears along with the primary wave. However, there exists a critical velocity of the beam beyond which the amplitude of the fast solitary wave starts diminishing and rarefactive slow beam mode propagates with growing amplitude. Whereas, the presence of charged dust impurity in the plasma reduces this critical beam velocity and a substantial modification in the phase velocity of the slow beam mode is observed with increasing dust density. Furthermore, the nonlinear wave velocity (Mach number) as well as the width of the compressive solitons are measured for different beam velocity and dust density, and are compared with those obtained from the K-dV equation. The experimental results are found in a well agreement with the theoretical predictions.
description: 24 pages, 09 figures; In the revised version (to appear in Phys. Plasmas), the title has been changed, two figures have been removed, some references are added and typos have been rectified wherever necessary
title: The untold diseases of the vagina: a review of the most common imaging findings
Creators: name: Costa, Ana Sofia
Publisher: name: European Congress of Radiology
Year: 2020
Subjects: subject: Genitourinary
subject: Genital / Reproductive system female
subject: CT
subject: MR
subject: Ultrasound
subject: Education
subject: Education and training
subject: Not applicable

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To review the anatomy and imaging appearance of the normal vagina; To describe and illustrate the most common and overlooked imaging findings of the...
Bias correction of daily GCM rainfall for crop simulation studies
Creators: name: Ines, Amor Valeriano M.
name: Hansen, James W.
Publisher: name: Columbia University
Year: 2006
Subjects: Crop yields--Forecasting
Rain and rainfall--Observations
Rain and rainfall--Forecasting
Hydrology

description: General circulation models (GCMs), used to predict rainfall at a seasonal lead-time, tend to simulate too many rainfall events of too low intensity relative to individual stations within a GCM grid cell. Even if bias in total rainfall is corrected relative to a target location, this distortion of frequency and intensity is expected to adversely affect simulations of crop growth and yield. We present a procedure that calibrates both the frequency and the intensity distribution of daily GCM rainfall relative to a target station, and demonstrate its application to maize yield simulation at a location in semi-arid Kenya. If GCM rainfall frequency is greater than observed frequency for a given month, averaged across years, GCM rainfall frequency is corrected by discarding rainfall events below a calibrated threshold. To correct the intensity distribution, each GCM rainfall amount above the calibrated threshold is mapped from the GCM intensity distribution onto the observed distribution. We used a gamma distribution for observed rainfall intensity, and considered both gamma and empirical distributions for GCM rainfall intensity. At the study location, the proposed correction procedure corrected both the mean and variance of monthly and seasonal GCM rainfall total, frequency and mean intensity. The empirical (GCM)-gamma (observed) transformation overestimated mean intensity slightly. A simple multiplicative shift did a better job of correcting monthly and seasonal rainfall totals, but left substantial frequency and intensity bias. All of the bias correction procedures improved maize yield simulations, but resulted in substantial negative mean bias. This bias appears to be associated with a tendency for the GCM rainfall to be more strongly autocorrelated than observed rainfall, resulting in unrealistically long dry spells during the growing season. Nonlinearity of crop response to the variability of water availability across GCM realizations may also contribute. Averaging simulated yields each year across multiple GCM realizations improved yield predictions. The proposed correction procedure provides an option for using the daily output of dynamic climate prediction models for impact studies in a manner that preserves any useful predictive information about the timing of rainfall within the season. However, its practical utility for yield forecasting at a long lead-time may be limited by the ability of GCMs to simulate rainfall with a realistic time structure.
title: Useful drugs for cardiac CT and MR: what the radiologist needs to know.
Creators: name: Rovere, Giuseppe
Publisher: name: European Congress of Radiology
Year: 2020
Subjects: subject: Not applicable
subject: Not applicable
subject: Drugs / Reactions
subject: Education
subject: Cost-effectiveness
subject: Chemistry
subject: MR
subject: CT
subject: Vascular
subject: Cardiac
subject: Arteries / Aorta
subject: Cardiac

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Demystify drugs used in cardiac imaging providing reference to encourage the radiologist to...
Methodological Overview of an African American Couple-Based HIV/STD Prevention Trial
Creators: name: NIMH Multisite HIV/STD Prevention Trial For African American Couples Group
Publisher: name: Columbia University
Year: 2008
Subjects: subject: Psychology
subject: FOS: Psychology
subject: Public health

description: Objective: To provide an overview of the NIMH Multisite HIV/STD Prevention Trial for African American Couples conducted in four urban areas: Atlanta, Los Angeles, New York, and Philadelphia. The rationale, study design methods, proposed data analyses, and study management are described. Design: This is a two arm randomized Trial, implementing a modified randomized block design, to evaluate the efficacy of a couples based intervention designed for HIV serodiscordant African American couples. Methods: The study phases consisted of formative work, pilot studies, and a randomized clinical trial. The sample is 535 HIV serodiscordant heterosexual African American couples. There are two theoretically derived behavioral interventions with eight group and individual sessions: the Eban HIV/STD Risk Reduction Intervention (treatment) versus the Eban Health Promotion Intervention (control). The treatment intervention was couples based and focused on HIV/STD risk reduction while the control was individual based and focused on health promotion. The two study conditions were structurally similar in length and types of activities. At baseline, participants completed an Audio Computer-assisted Self Interview (ACASI) interview as well as interviewer-administered questionnaire, and provided biological specimens to assess for STDs. Similar follow-up assessments were conducted immediately after the intervention, at 6 months, and at 12 months. Results: The Trial results will be analyzed across the four sites by randomization assignment. Generalized estimating equations (GEE) and mixed effects modeling (MEM) are planned to test: (1) the effects of the intervention on STD incidence and condom use as well as on mediator variables of these outcomes, and (2) whether the effects of the intervention differ depending on key moderator variables (e.g., gender of the HIV-seropositive partners, length of relationship, psychological distress, sexual abuse history, and substance abuse history). Conclusions: The lessons learned from the design and conduct of this clinical trial provide guidelines for future couples based clinical trials in HIV/STD risk reduction and can be generalized to other couples based behavioral interventions.
The Science Case for the Atacama Large Aperture Submillimetre Telescope
Creators: name: Booth, Mark
Publisher: name: Zenodo
Year: 2023

description: ALMA has revolutionised (sub-)millimetre astronomy and will continue to provide exciting discoveries at the cutting edge of astronomy research for many decades to come, particularly with the advancements provided by the development roadmap. In order to make the most of the detailed imagery and spectra that ALMA can provide, we need the next generation of large scale observations to find the best targets for high resolution follow-up. To get there we need a dedicated, new facility with a large throughput to systematically sample the sky. The AtLAST Consortium is currently building the science and technical case for this facility. Here I'll present a sample of the detailed science case studies that we are currently developing in order to define the telescope requirements. As a 50m single dish telescope with a 2-degree field of view, the strength of AtLAST will be cases where a large field of view and/or sensitivity to large-scale structure is crucial, including imaging our own Sun, mapping the dynamics of the galactic plane and conducting deep surveys of high redshift galaxies. The huge advances AtLAST will provide over current facilities will result in a fundamental change to our understanding of the submillimetre sky whilst also ensuring that ALMA does not become source starved.
Calcium sensitivity of residual force enhancement in rabbit skinned fibers
Creators: name: Joumaa, Venus
name: Herzog, Walter
Publisher: name: American Journal of Physiology
Year: 2014
Subjects: calcium
signaling
cross-brdiges
muscle
titin
myofibrils

description: Isometric force after active stretch of muscles is higher than the purely isometric force at the corresponding length. This property is termed residual force enhancement. Active force in skeletal muscle depends on calcium attachment characteristics to the regulatory proteins. Passive force has been shown to influence calcium attachment characteristics, specifically the sarcomere length dependence of calcium sensitivity. Since one of the mechanisms proposed to explain residual force enhancement is the increase in passive force that results from engagement of titin upon activation and stretch, our aim was to test if calcium sensitivity of residual force enhancement was different from that of its corresponding purely isometric contraction and if such a difference was related to the molecular spring titin. Force-pCa curves were established in rabbit psoas skinned fibers for reference and residual force-enhanced states at a sarcomere length of 3.0 μm 1) in a titin-intact condition, 2) after treatment with trypsin to partially eliminate titin, and 3) after treatment with trypsin and osmotic compression with dextran T-500 to decrease the lattice spacing in the absence of titin. The force-pCa curves of residual force enhancement were shifted to the left compared with their corresponding controls in titin-intact fibers, indicating increased calcium sensitivity. No difference in calcium sensitivity was observed between reference and residual force-enhanced contractions in trypsin-treated and osmotically compressed trypsin-treated fibers. Furthermore, calcium sensitivity after osmotic compression was lower than that observed for residual force enhancement in titin-intact skinned fibers. These results suggest that titin-based passive force regulates the increase in calcium sensitivity of residual force enhancement by a mechanism other than reduction of the myofilament lattice spacing.
Neurobiological Correlates of Anxiety and Comorbid Social Phobia in Adolescents with Major Depressive Disorder: A Repetitive Transcranial Magnetic Stimulation Clinical Trial
Creators: name: Worth, Madelyn Reid
Publisher: name: Graduate Studies
Year: 2018
Subjects: subject: rTMS
subject: Major depressive disorder
subject: Social anxiety
subject: Educational Psychology

description: This study examined repetitive transcranial magnetic stimulation (rTMS) as a treatment for adolescents with major depressive disorder. The study was exploratory, considering the potential influence of comorbid anxiety on treatment response and neurobiological correlates. Adolescents underwent a three-week rTMS clinical trial. Depression and anxiety symptoms were compared pre- and post-treatment to determine treatment response. As well fMRI scans were reviewed, identifying functional connectivity differences based upon comorbid anxiety. Findings indicated a significant relation between depressive symptom response and comorbid social phobia symptoms such that participants without social phobia symptoms were more likely to show a significant reduction in depressive symptoms. Neurobiological differences in terms of functional connectivity were found, based upon anxiety severity, comorbid social phobia symptoms, and anxiety symptom treatment response. These findings indicate that the presence of comorbid anxiety is associated with neurobiological differences that may in turn influence rTMS treatment response. Discussions of these findings are included in this document.
title: Differential diagnosis in lesions of the cerebellopontine angle
Creators: name: Sánchez Neila, Beatriz
Publisher: name: European Congress of Radiology
Year: 2020
Subjects: subject: Not applicable
subject: Retrospective
subject: Pathology
subject: Artifacts
subject: Contrast agent-intravenous
subject: MR
subject: CT
subject: Neuroradiology brain
subject: Neuro
subject: Performed at one institution

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: 1.- To describe the normal anatomy of the cerebellopontine angle (CPA). 2.- To illustrate the radiological features of lesions involving the CPA using a multimodality approach with computed tomography (CT) and magnetic resonance imaging (MRI). 3.-...
Unidirectional Pinning and Hysteresis of Spatially Discordant Alternans in Cardiac Tissue
Creators: name: Skardal, Per Sebastian
name: Karma, Alain
name: Restrepo, Juan G.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Pattern Formation and Solitons (nlin.PS)
subject: Dynamical Systems (math.DS)
subject: Biological Physics (physics.bio-ph)
subject: Tissues and Organs (q-bio.TO)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: FOS: Biological sciences

description: Spatially discordant alternans is a widely observed pattern of voltage and calcium signals in cardiac tissue that can precipitate lethal cardiac arrhythmia. Using spatially coupled iterative maps of the beat-to-beat dynamics, we explore this pattern's dynamics in the regime of a calcium-dominated period-doubling instability at the single cell level. We find a novel nonlinear bifurcation associated with the formation of a discontinuous jump in the amplitude of calcium alternans at nodal lines separating discordant regions. We show that this jump unidirectionally pins nodal lines by preventing their motion away from the pacing site following a pacing rate decrease, but permitting motion towards this site following a rate increase. This unidirectional pinning leads to strongly history-dependent nodal line motion that is strongly arrhythmogenic.
description: 4 pages, 3 figures
title: Key points in computed tomographic (CT) evaluation of perirenal transplant fluid collections
Creators: name: Cristache, Ioan Andrei
Publisher: name: European Congress of Radiology
Year: 2020
Subjects: subject: Observational
subject: Retrospective
subject: Transplantation
subject: Haemorrhage
subject: Abscess
subject: Complications
subject: CT
subject: Urinary Tract / Bladder
subject: Kidney
subject: Genitourinary
subject: Performed at one institution

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: LEARNING OBJECTIVES: 1. To present, illustrate and classify the main CT aspects of the most common urological complications after renal transplant: fluid collections. 2. To assess the importance of CT evaluation for guiding the therapeutic approach...
Regulation of neutral lipid metabolism through phosphorylation of the yeast acyltransferase Gpt2
Creators: name: Tavassoli, Marjan
Publisher: name: Graduate Studies
Year: 2018
Subjects: subject: Glycerol-3-phosphate acyltransferase (GPATs)
subject: Neutral Lipids
subject: Triglycerides
subject: Yeast
subject: Education--Sciences

description: Glycerol-3-phosphate acyltransferases (GPATs) catalyze the first step of glycerol-3-phosphate acylation at the sn-1 position producing lyso-phosphatidic acid. This is the committed and rate limiting step in de-novo synthesis of phosphatidic acid, the key intermediate in the glycerophospholipids and triacylglycerols (TAG) biosynthetic pathways. Two GPATs have been identified in S cerevisiae, Gpt2p and Sct1p. The role of phosphorylation in the serine-rich C-terminal tail of Gpt2p is unknown. In this work is shown that lack of phosphorylation on three conserved phosphorylation sites (S664, S668, S671) of Gpt2p alters protein stability, activity and neutral lipid metabolism. Specifically, a triple Gpt2p mutant (Gpt2-3A) where all these three residues were converted to alanine to mimic dephosphorylation induce a rise in the protein abundance, displayed more activity and resultedi in higher accumulation of DAG and TAG during exponential phase of growth. Lack of phosphorylation on Gpt2p delayed TAG lipolysis upon growth resumption from stationary phase which might be due to a futile TAG cycle that slows down mobilization of produced acyl-chains channeled for the formation of phospholipids. Unregulated Gpt2p probably remains constitutively active and displaces Sct1p in exponential phase. Notoriously, Sct1p is found associated with lipid droplets in cells carrying Gpt2-3A mutant. Considering Sct1p has never been identified in lipid droplets proteomes this consequence of having a constitutively de-phosphorylated Gpt2p might explain the alterations seen in neutral lipid metabolism of this mutant cells.
Homeless Family Shelters and Family Homelessness
Creators: name: Berlin, Gordon
name: McAllister, William
Publisher: name: Columbia University
Year: 1994
Subjects: Homeless families
Shelters for the homeless
Homelessness--Government policy

description: One of the more valuable contributions of Peter Rossi's article is to remind us of the critical role that shelters play in defining and responding to the problem of homeless families. As Rossi points out, shelters help form our conceptualization of the problem-what kinds of families are homeless and why as well as their number. Perhaps more important, increasingly sophisticated shelters have come to define our policy response to family homelessness. Rossi reports that the number of family shelters soared throughout the middle and late 1980s and that they changed from simply providing a roof and food in an emergency to also providing social, medical, and psychological services for longer periods in more private quarters. And the future promises much more of the same. If the Department of Housing and Urban Development (HUD) follows the suggestions its Assistant Secretary for Community Planning made for New York City, the Clinton homeless family policy will likely center around shelters (New York Commission on the Homeless, 1992). Here we want to extend Rossi's emphasis on the role of shelters in dealing with family homelessness. We make two arguments. One, shelters define the problem of family homelessness and therefore a particular conception of that problem. Two, shelters act to select from the population of poor families those who are worst off in some ways (housing, income, managing their lives, drug or alcohol addictions) and least able or willing to cope with circumstances other poor families do handle. We then explain that one reason why shelters play this role is because the ratio of "worst off, least able" poor families to the total number of poor families is so small that a device is needed to identify these families. Shelters are such a device. In the final section, we fill a lacuna in Rossi's causal analysis with a few ideas as to why shelter growth exploded in the mid-1980s and we explain our disagreement with Rossi's major policy suggestions. Because shelters house such a small proportion of all poor families and because few families stay sheltered very long, Rossi's recommendations are a very inefficient way to end homelessness. Also, the amounts of money entailed in his proposals are so large they are unlikely to be appropriated; and if lesser amounts are appropriated, they are unlikely, absent targeting, to reach families apt to become homeless.
title: Assessing the Quality of CT Reporting in Suspected Appendicitis: In-sourcing vs Out sourcing
Creators: name: Karthigan, Ravindran
Publisher: name: European Congress of Radiology
Year: 2020
Subjects: subject: Abdominal Viscera
subject: Abdomen
subject: Colon
subject: Emergency
subject: CT
subject: Teleradiology
subject: Decision analysis
subject: Acute
subject: Workforce
subject: Retrospective
subject: Cross-sectional study
subject: Performed at one institution

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Roughly 30% of all surgical emergencies who come through the emergency department presenting with an acute abdomen are diagnosed with acute appendicitis. CT scans have been very useful in the diagnosis of said condition given its high predictive...
Generalized Harmonic Equations in 3+1 Form
Creators: name: Brown, J. David
Publisher: name: arXiv
Year: 2011
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The generalized harmonic equations of general relativity are written in 3+1 form. The result is a system of partial differential equations with first order time and second order space derivatives for the spatial metric, extrinsic curvature, lapse function and shift vector, plus fields that represent the time derivatives of the lapse and shift. This allows for a direct comparison between the generalized harmonic and the Arnowitt-Deser-Misner formulations. The 3+1 generalized harmonic equations are also written in terms of conformal variables and compared to the Baumgarte-Shapiro-Shibata-Nakamura equations with moving puncture gauge conditions.
description: This version (accepted for publication) contains some minor corrections and additional references
Phenology of Stipa krylovii Roshev. and Stipa tianschanica var. klemenzii Roshev., species dominating the vegetation communities of Hustai National Park
Creators: name: Tserendulam, Ts.
name: Oyuntsetseg, B.
name: Nyambayar, D.
name: Bayarsaikhan, U.
name: Action, Nutag
Publisher: name: Mountain Scholar
Year: 2015
Subjects: phenology
growing period changes
Kryllov's feather grass
Klement's feather grass

description: Includes bibliographical references.
description: Presented at the Building resilience of Mongolian rangelands: a trans-disciplinary research conference held on June 9-10, 2015 in Ulaanbaatar, Mongolia.
description: Hustai National Park (HNP), which is one of the important parts of the Mongolian Special Protection Areas network, was founded in 1992 with the purpose of reintroducing the Takhi horse (Equus ferus przewalskii). HNP vegetation phenology research was first done in 1999 and since 2003 has been conducted each year between 24th of April and 24th of September, every 10 days. The purpose of this study is to identify, with the help of dominant species, the response of vegetation growing period to climate changes and to clarify features of species' phenology changes. As a result of the research we identified and recorded general trends of dominant vegetation phenology stages and how these changes respond to environmental factors (air temperature and precipitation). Comparison of the phenology stages of the two grasses dominant in the mountain steppe and steppe communities, Stipa tianschanica var. klemenzii Roshev. and Stipa krylovii Roshev. identified that the May and June precipitation amount had a significant effect on the beginning of the species' spring growing period (p<0.027). The results show that the vegetation growing period of the species has been increasing in the mountain steppe communities.
Near-Surface Soil Moisture Assimilation for Quantifying Effective Soil Hydraulic Properties under Different Hydroclimatic Conditions
Creators: name: Ines, Amor Valeriano M.
name: Mohanty, Binayak P.
Publisher: name: Columbia University
Year: 2008
Subjects: Hydrology

description: We conducted a validation study of a newly developed near-surface soil moisture assimilation scheme for estimating effective soil hydraulic properties using soil moisture data from different hydroclimatic regions, including semihumid Oklahoma, humid Iowa and Illinois, and temperate humid China. A genetic algorithm (GA) was used to estimate the effective soil water retention θ(h) and hydraulic conductivity K(h) functions of an effective modeling domain by minimizing errors between observed near-surface soil moisture and values simulated with the Richards-based Soil–Water–Atmosphere–Plant (SWAP) model. The parameter estimation approach considered uncertainties in the initial and bottom boundary conditions, rooting depth, and root density by creating simulation ensembles based on combinations of several modeling conditions and a multipopulation approach in the GA to estimate uncertainties in the derived soil hydraulic properties. The results showed that θ(h) is not very sensitive to variations in the initial and boundary conditions, rooting depth, and root density applied on the modeling domain. The value of K(h) was found to be more sensitive to variations in rooting depth and root density than to variations in the initial and boundary conditions. With the modeling domain better represented, the estimated θ(h) and K(h) functions were found to be satisfactory in most of the locations studied. They were validated using laboratory-measured θ(h) and K sat, observed soil moisture in the field, and soil hydraulic properties from the UNSODA database. Our study indicates, however, that the homogeneous-medium assumption commonly used to effectively describe a heterogeneous system may fail to closely represent a highly heterogeneous (layered) soil profile if only the near-surface soil moisture data are used to define the subsurface soil hydraulic properties. Additional soil moisture data from deeper depths may be needed to better estimate the effective soil hydraulic properties of highly heterogeneous systems.
title: Splenic artery steal syndrome after liver transplantation: the role of imaging and endovascular procedures
Creators: name: Soprenic, Vanja
Publisher: name: European Congress of Radiology
Year: 2020
Subjects: subject: Abdominal Viscera
subject: Interventional vascular
subject: Liver
subject: Spleen
subject: Catheter arteriography
subject: CT
subject: Ultrasound-Power Doppler
subject: Embolisation
subject: Transplantation
subject: Not applicable

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: ·To discuss the imaging criteria for diagnosis of splenic artery steal syndrome (SASS). ·To present the role of interventional radiology in the management of...
Concrete Fictions and Hegemonic Methodologies: Doing Policy Research in Government
Creators: name: McAllister, William
Publisher: name: Columbia University
Year: 1994
Subjects: Social sciences--Research
Public policy (Law)

description: Faced with having to justify programs to offices of management and budget, government agencies generate numbers which describe expected program impacts. But the assumptions or data on which these numbers are based are frequently suspect, as is the utility of relying on counts and modeling techniques for evaluating the achievement of program aims. The result is that agencies often create "concrete fictions," hard numbers with feet of (soft) clay. Offices of management and budget are able to make their methodology "hegemonic" because agencies usually have to secure their approval to get funding. But imposing this methodology encourages agencies to use research staffs more to defend against the budget office than to help create effective programs, creates differences between the expectations of government and the public, and fosters the overrepresentation of particular interests.
title: A Pictorial Review of Fetal Corpus Callosum Imaging by 2D and 3D Ultrasound
Creators: name: JADHAV, MANOJ
Publisher: name: European Congress of Radiology
Year: 2020
Subjects: subject: Ultrasound
subject: Foetal imaging
subject: CNS
subject: Neuro
subject: Diagnostic procedure
subject: Congenital
subject: Foetus
subject: Retrospective
subject: Diagnostic or prognostic study
subject: Performed at one institution

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To demonstrate normal anatomy and relationship of fetal corpus callosum. To obtain ‘virtual’ mid-sagittal plane images reconstructed from an axial approach using 3D imaging techniques like VCI (Volume Contrast Imaging) and Omni View. To...
Non-Abelian spin singlet states of two-component Bose gases in artificial gauge fields
Creators: name: Graß, Tobias
name: Juliá-Díaz, Bruno
name: Barberán, Nuria
name: Lewenstein, Maciej
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We study strongly correlated phases of a pseudo-spin-1/2 Bose gas in an artificial gauge field using the exact diagonalization method. The atoms are confined in two dimensions and interact via a two-body contact potential. In Abelian gauge fields, pseudo-spin singlets are favored by pseudo-spin independent interactions. We find a series of incompressible phases at fillings ν=2k/3. By comparison with the non-Abelian spin singlet (NASS) states, constructed as zero-energy eigenstates of a (k+1)-body contact interaction, we classify the non-trivial topology of the states. An additional spin-orbit coupling is shown to switch between NASS-like states and spin-polarized phases from the Read-Rezayi series.
description: 4 pages, 3 figures
Combining remote sensing-simulation modeling and genetic algorithm optimization to explore water management options in irrigated agriculture
Creators: name: Ines, Amor Valeriano M.
name: Honda, Kiyoshi
name: Das Gupta, Ashim
name: Droogers, Peter
name: Clemente, Roberto S.
Publisher: name: Columbia University
Year: 2006
Subjects: Irrigation farming
Water resources development--Management
Remote sensing

description: We present an innovative approach to explore water management options in irrigated agriculture considering the constraints of water availability and the heterogeneity of irrigation system properties. The method is two-folds: (i) system characterization using a stochastic data assimilation procedure where the irrigation system properties and operational management practices are estimated using remote sensing (RS) data; and (ii) water management optimization where we explored water management options under various levels of water availability. We set up a soil–water–atmosphere–plant model (SWAP) in a deterministic–stochastic mode for regional modeling. The distributed data, e.g. sowing dates, irrigation practices, soil properties, depth to groundwater and water quality, required as inputs for the regional modeling were estimated by minimizing the residuals between the distributions of field-scale evapotranspiration (ET) simulated by the regional application of SWAP, and by surface energy balance algorithm for land (SEBAL) using two Landsat7 ETM+ images. The derived distributed data were used as inputs in exploring water management options. Genetic algorithm was used in data assimilation and water management optimizations. The case study was conducted in Bata minor (lateral canal), Kaithal, Haryana, India during 2000–2001 rabi (dry) season. Our results showed that under limited water condition, regional wheat yield could improve further if water and crop management practices are considered simultaneously and not independently. Adjusting sowing dates and their distribution in the irrigated area could improve the regional yield, which also complements the practice of deficit irrigation when water availability is largely a constraint. This result was also found in agreement with the scenario that water is non-limited with the exception that the farmers have more degrees of freedom in their agricultural activities. An improvement of the regional yield to 8.5% is expected under the current scenario.
Rethinking Research on Forming Typologies of Homelessness
Creators: name: McAllister, William
name: Lennon, Mary Clare
name: Kuang, Li
Publisher: name: Columbia University
Year: 2011
Subjects: Social sciences--Research

description: In homelessness research and policymaking, it seems to be axiomatic that single adults experience 3 temporally based types of homelessness: chronic, episodic, and transitional. We discuss problems with the theorization of this typology and with the research design, data analysis, and time-aggregated conceptualization and measurement of temporality in the empirical work supporting the typology. To address the latter, we suggest a time-patterned approach to temporality and report a 10-group typology that differs significantly from the more familiar 3-group typology. We argue that which approach is used—and how typologies are developed more generally—should be based on theory and the uses to which typologies are put rather than on claims to being more true.
On the relativistic BGK-Boltzmann model: asymptotics and hydrodynamics
Creators: name: Bellouquid, Abdel
name: Calvo, Juan
name: Nieto, Juanjo
name: Soler, Juan
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: 83A99

description: The generalization of the BGK relaxation model to the special relativity setting is revisited here. We deal with several issues related to this relativistic kinetic model which seem to have been overlooked in the previous physical literature, including the unique determination of associated physical parameters, classical, ultra-relativistic and hydrodynamical limits, maximum entropy principles and the analysis of the linearized operator.
description: 37 pages