cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Risk of thromboembolic events in patients Co-treated with factor xa-inhibiting direct oral anticoagulants and anti-seizure medications: insights from pharmacovigilance data
Creators: name: Ding, Lingqing
name: Chen, Congqin
name: Yang, Yongkuan
name: Xiao, Jie
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Limited data have raised concerns about an increased risk of thromboembolic adverse events in atrial fibrillation (AF) patients co-treated with factor Xa-inhibiting direct oral anticoagulants (FXa-DOACs) and anti⁃seizure medications (ASMs). However, evidence regarding this association remains controversial. This study aims to investigate the impact of ASMs on the reporting of thromboembolic events in FXa-DOAC-treated patients. This study analyzed data from the FDA Adverse Event Reporting System (FAERS) between 2011Q3 and 2024Q1 using the weighted composite score integrated by four pharmacovigilance signals [reporting odds ratio (ROR), Empirical Bayes Geometric Mean (EBGM), additive model and multiplicative model]. A total of 177 cases of thromboembolic events were identified in patients using combined FXa-DOACs and ASMs. Levetiracetam together with FXa-DOACs was associated with an increased risk of thromboembolic events, particularly apixaban (ROR: 2.29, 95%CI 1.56–3.38; EBGM05:1.32; additive model:0.14 > 0; multiplicative mode: 2.47 > 1;composite score:1) and rivaroxaban (ROR:3.81, 95% CI 2.77–5.26; EBGM05:1.99; additive model:0.13; multiplicative model:1.71; composite score:1). Valproic acid was associated with thromboembolic risk when with rivaroxaban (ROR:4.80, 95%CI 2.50–9.19; EBGM05:1.64; additive model:0.29; multiplicative model:8.48; composite score:1). This study suggests that the concomitant use of levetiracetam and valproic acid with FXa-DOACs is associated with an increased risk of thromboembolic events.
sj-docx-2-sat-10.1177_11782218211033298 – Supplemental material for Changes in Alcohol Habits Among Workers During the Confinement of COVID-19: Results of a Canadian Cross-Sectional Survey
Creators: name: Mongeau-Pérusse, Violaine
name: Rizkallah, Elie
name: Bruneau, Julie
name: Chênevert, Denis
name: Menvielle, Loick
name: Jutras-Aswad, Didier
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, sj-docx-2-sat-10.1177_11782218211033298 for Changes in Alcohol Habits Among Workers During the Confinement of COVID-19: Results of a Canadian Cross-Sectional Survey by Violaine Mongeau-Pérusse, Elie Rizkallah, Julie Bruneau, Denis Chênevert, Loick Menvielle and Didier Jutras-Aswad in Substance Abuse: Research and Treatment
sj-pdf-4-tar-10.1177_17534666211028072 – Supplemental material for LncRNA CASC2 is involved in the development of chronic obstructive pulmonary disease via targeting miR-18a-5p/IGF1 axis
Creators: name: Liu, Panpan
name: Zhang, Huali
name: Zeng, Haizhu
name: Meng, Yingxia
name: Gao, Hongchang
name: Zhang, Meilan
name: Zhao, Lei
Publisher: name: SAGE Journals
Year: 2021
Subjects: Aged Health Care
Pharmacology and Pharmaceutical Sciences not elsewhere classified
Respiratory Diseases

description: Supplemental material, sj-pdf-4-tar-10.1177_17534666211028072 for LncRNA CASC2 is involved in the development of chronic obstructive pulmonary disease via targeting miR-18a-5p/IGF1 axis by Panpan Liu, Huali Zhang, Haizhu Zeng, Yingxia Meng, Hongchang Gao, Meilan Zhang and Lei Zhao in Therapeutic Advances in Respiratory Disease
Drug-induced Guillain-Barré Syndrome: a disproportionality analysis based on the US FDA adverse event reporting system
Creators: name: Zhong, Rujia
name: Li, Jiahao
name: Zhang, Feng
name: Guo, Yi
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Guillain-Barré Syndrome (GBS) is a rare but severe neurological disorder often precipitated by infections, vaccines, and potentially by certain medications. Drug-induced GBS, though less commonly reported, presents significant diagnostic and therapeutic challenges. This study investigates the correlation between various medications and the onset of GBS. We conducted a retrospective pharmacovigilance analysis using data from the FDA Adverse Event Reporting System (FAERS) from Q1 2004 to Q1 2024. The analysis focused on identifying drugs frequently associated with GBS and examining the time-to-onset and severity of these events. From over 17 million adverse events, 1,869 cases were identified as drug-induced GBS. Monoclonal antibodies and immunomodulators were the most frequently implicated drug classes. The median time-to-onset for GBS was within the first 30 days following drug exposure. Approximately 51.8% of the cases resulted in severe outcomes, such as hospitalization or disability. Drugs such as brentuximab vedotin and efalizumab showed strong associations with GBS occurrences. This study highlights the importance of monitoring for GBS symptoms following the administration of certain medications, particularly those that affect immune function, and underscores the need for healthcare providers to be aware of the potential neurological risks associated with these medications.
sj-pdf-1-esp-10.1177_09589287211018146 – Supplemental material for Do social investment policies reduce income inequality? An analysis of industrial countries
Creators: name: Sakamoto, Takayuki
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160607 International Relations
subject: FOS: Political science
subject: 160512 Social Policy

description: Supplemental material, sj-pdf-1-esp-10.1177_09589287211018146 for Do social investment policies reduce income inequality? An analysis of industrial countries by Takayuki Sakamoto in Journal of European Social Policy
Are trees forms? On formalism, material feminism, and historical literature
Creators: name: Phillips, George
Publisher: name: Humanities Commons
Year: 2020
Subjects: subject: Ecocriticism
subject: Materialism
subject: Woolf, Virginia, 1882-1941
subject: Ecofeminism

description: This essay draws on formalist cultural studies and material feminism to argue for a new approach in modernist studies, which I call formalist materialism, an approach that reads ecological forms alongside aesthetic forms. Such an approach may have distinct advantages. Formalist materialism illuminates a new direction for formalists by connecting forms to embodiment, ecology, and material substances. It also offers a novel path for feminist materialists by suggesting historical objects and situations where human and nonhuman agencies might be clearer. As I demonstrate in readings of Karel Čapek and Virginia Woolf, this model of reading also might help reinvigorate ways of approaching early-twentieth-century modernism in our time of ecological crisis, but without looking for signs of our concerns and epistemologies in the past. [Abstract amended from original.]
sj-docx-1-tam-10.1177_17588359211022905 – Supplemental material for Oral vinorelbine and cisplatin as first-line therapy for advanced squamous NSCLC patients: a prospective randomized international phase II study (NAVoTrial 03)
Creators: name: Grossi, Francesco
name: Jaśkiewicz, Piotr
name: Ferreira, Marion
name: Czyżewicz, Grzegorz
name: Kowalski, Dariusz
name: Ciuffreda, Libero
name: Garcia-Gomez, Ramon
name: Caruso, Salvatore
name: Bosch-Barrera, Joaquim
name: Gautier, Stéphanie
name: Ta Thanh Minh, Christine
name: Henriet, Sébastien
name: de Castro, Gilberto
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 110203 Respiratory Diseases

description: Supplemental material, sj-docx-1-tam-10.1177_17588359211022905 for Oral vinorelbine and cisplatin as first-line therapy for advanced squamous NSCLC patients: a prospective randomized international phase II study (NAVoTrial 03) by Francesco Grossi, Piotr Jaśkiewicz, Marion Ferreira, Grzegorz Czyżewicz, Dariusz Kowalski, Libero Ciuffreda, Ramon Garcia-Gomez, Salvatore Caruso, Joaquim Bosch-Barrera, Stéphanie Gautier, Christine Ta Thanh Minh, Sébastien Henriet and Gilberto de Castro in Therapeutic Advances in Medical Oncology
sj-docx-4-tam-10.1177_17588359211022905 – Supplemental material for Oral vinorelbine and cisplatin as first-line therapy for advanced squamous NSCLC patients: a prospective randomized international phase II study (NAVoTrial 03)
Creators: name: Grossi, Francesco
name: Jaśkiewicz, Piotr
name: Ferreira, Marion
name: Czyżewicz, Grzegorz
name: Kowalski, Dariusz
name: Ciuffreda, Libero
name: Garcia-Gomez, Ramon
name: Caruso, Salvatore
name: Bosch-Barrera, Joaquim
name: Gautier, Stéphanie
name: Ta Thanh Minh, Christine
name: Henriet, Sébastien
name: de Castro, Gilberto
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 110203 Respiratory Diseases

description: Supplemental material, sj-docx-4-tam-10.1177_17588359211022905 for Oral vinorelbine and cisplatin as first-line therapy for advanced squamous NSCLC patients: a prospective randomized international phase II study (NAVoTrial 03) by Francesco Grossi, Piotr Jaśkiewicz, Marion Ferreira, Grzegorz Czyżewicz, Dariusz Kowalski, Libero Ciuffreda, Ramon Garcia-Gomez, Salvatore Caruso, Joaquim Bosch-Barrera, Stéphanie Gautier, Christine Ta Thanh Minh, Sébastien Henriet and Gilberto de Castro in Therapeutic Advances in Medical Oncology
Real-world safety and effectiveness of intravenous fomepizole in patients with ethylene glycol and methanol poisoning in Japan: results of a 7-year post-marketing surveillance study
Creators: name: Yoshioka, Toshiharu
name: Koyanagi, Momoha
name: Yoshida, Naoki
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Virology

description: Fomepizole is a competitive alcohol dehydrogenase inhibitor used for the treatment of ethylene glycol and methanol poisoning. We evaluated the safety and effectiveness of fomepizole in patients with ethylene glycol or methanol poisoning in Japan. This retrospective post-marketing surveillance study conducted in Japan registered patients who received fomepizole intravenous infusion per the package insert (January 2015−June 2022). Endpoints included adverse drug reactions/infections (ADRs), arterial blood pH, and treatment outcomes. Of 147 patients registered (91 institutions), 131 and 126 were included in the safety and effectiveness analysis sets, respectively. Mean age was 43.6 years, and 66.4% were male. Mean time from poison ingestion to treatment was 15.1 hours; 66.4% received concomitant hemodialysis. No serious ADRs were reported. ADRs were reported in seven patients; the most-reported ADR was vomiting (2.3%). Seven patients died, 105 survived without sequelae, and 19 survived with sequelae. Most common sequelae were renal failure or renal dysfunction. Mean arterial blood pH increased to 7.4 by 4 hours of treatment, remaining stable for 24 hours post-treatment. Fomepizole is well tolerated and helps improve clinical outcomes in patients with ethylene glycol or methanol poisoning in Japan. Japanese Pharmaceutical Information Center (JapicCTI-152817).
Supplemental Material, sj-pdf-2-teu-10.1177_13548166211015512 - Do countries’ geographical locations moderate the tourism-led economic growth nexus in sub-Saharan Africa?
Creators: name: Baidoo, Francis
name: Agbloyor, Elikplimi Komla
name: Fiador, Vera Ogeh Lassey
name: Marfo, Nana Amaniampong
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Economics
subject: 150402 Hospitality Management
subject: FOS: Economics and business

description: Supplemental Material, sj-pdf-2-teu-10.1177_13548166211015512 for Do countries’ geographical locations moderate the tourism-led economic growth nexus in sub-Saharan Africa? by Francis Baidoo, Elikplimi Komla Agbloyor, Vera Ogeh Lassey Fiador and Nana Amaniampong Marfo in Tourism Economics
Practicing Culturally Sensitive Care: What Can Health Care Providers Do?
Creators: name: Jin, Tao
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Communication studies

description: This study investigates health care providers’ perceptions and practice in culturally sensitive care. 8 in-depth interviews were conducted with health care providers that lasted an average of 25 minutes. The findings revealed that health care providers tend to understand culturally sensitive care within the patient-centered care perspective. Their practice of culturally sensitive care is partially limited by language barriers, cultural barriers, and limited trainings in cultural sensitivity, while interpreting services, verbal and nonverbal communication strategies, collaborations with colleagues and self-education promote their practice of it. These findings underscore the importance of acknowledging health care providers’ influences in promoting culturally sensitive care, and the necessity of offering adequate amount of teachings and trainings in cultural sensitivity at health care programs and hospitals.
sj-docx-1-vaw-10.1177_10778012211019047 – Supplemental material for Help-Seeking to Cope With Experiences of Violence Among Women Living With HIV in Canada
Creators: name: Gormley, Rebecca
name: Nicholson, Valerie
name: Parry, Rebeccah
name: Lee, Melanie
name: Webster, Kath
name: Sanchez, Margarite
name: Cardinal, Claudette
name: Li, Jenny
name: Wang, Lu
name: Balleny, Rosa
name: de Pokomandy, Alexandra
name: Loutfy, Mona
name: Kaida, Angela
Publisher: name: SAGE Journals
Year: 2021
Subjects: Criminology not elsewhere classified

description: Supplemental material, sj-docx-1-vaw-10.1177_10778012211019047 for Help-Seeking to Cope With Experiences of Violence Among Women Living With HIV in Canada by Rebecca Gormley, Valerie Nicholson, Rebeccah Parry, Melanie Lee, Kath Webster, Margarite Sanchez, Claudette Cardinal, Jenny Li, Lu Wang, Rosa Balleny, Alexandra de Pokomandy, Mona Loutfy and Angela Kaida in Violence Against Women
Additional file 1 of Are changes in patient-reported outcomes prognostic for diffuse large B-Cell lymphoma survival? Results from the GOYA trial
Creators: name: Yan, Jessie T.
name: Bel, Célia
name: Trask, Peter C.
name: Lo, Ernest
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Hematology

description: Supplementary Material 1
Supplemental Material, sj-pdf-1-ahp-10.1177_08901171211030849 - Perceptions of Arguments in Support of Policies to Reduce Sugary Drink Consumption Among Low-Income White, Black and Latinx Parents of Young Children
Creators: name: Cannon, Julie S.
name: Farkouh, Elizabeth K.
name: Winett, Liana B.
name: Dorfman, Lori
name: Ramírez, A. Susana
name: Lazar, Spencer
name: Niederdeppe, Jeff
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental Material, sj-pdf-1-ahp-10.1177_08901171211030849 for Perceptions of Arguments in Support of Policies to Reduce Sugary Drink Consumption Among Low-Income White, Black and Latinx Parents of Young Children by Julie S. Cannon, Elizabeth K. Farkouh, Liana B. Winett, Lori Dorfman, A. Susana Ramírez, Spencer Lazar and Jeff Niederdeppe in American Journal of Health Promotion
sj-docx-1-hol-10.1177_09596836211033197 – Supplemental material for Organic geochemical characterization of Early-Mid-Holocene swamp deposits near the Neolithic settlement in Yenikapı-Istanbul: Assessment of environmental variability and anthropogenic impacts
Creators: name: Yalçın, Mehmet Namık
name: Wilkes, Heinz
name: Plessen, Birgit
Publisher: name: SAGE Journals
Year: 2021
Subjects: Geography
History

description: Supplemental material, sj-docx-1-hol-10.1177_09596836211033197 for Organic geochemical characterization of Early-Mid-Holocene swamp deposits near the Neolithic settlement in Yenikapı-Istanbul: Assessment of environmental variability and anthropogenic impacts by Mehmet Namık Yalçın, Heinz Wilkes and Birgit Plessen in The Holocene
sj-docx-5-hol-10.1177_09596836211033197 – Supplemental material for Organic geochemical characterization of Early-Mid-Holocene swamp deposits near the Neolithic settlement in Yenikapı-Istanbul: Assessment of environmental variability and anthropogenic impacts
Creators: name: Yalçın, Mehmet Namık
name: Wilkes, Heinz
name: Plessen, Birgit
Publisher: name: SAGE Journals
Year: 2021
Subjects: Geography
History

description: Supplemental material, sj-docx-5-hol-10.1177_09596836211033197 for Organic geochemical characterization of Early-Mid-Holocene swamp deposits near the Neolithic settlement in Yenikapı-Istanbul: Assessment of environmental variability and anthropogenic impacts by Mehmet Namık Yalçın, Heinz Wilkes and Birgit Plessen in The Holocene
Additional file 2 of Are changes in patient-reported outcomes prognostic for diffuse large B-Cell lymphoma survival? Results from the GOYA trial
Creators: name: Yan, Jessie T.
name: Bel, Célia
name: Trask, Peter C.
name: Lo, Ernest
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Hematology

description: Supplementary Material 2
Supplemental Material, sj-pdf-1-vet-10.1177_03009858211031843 - Reproductive tract neoplasia in adult female Asian elephants (Elephas maximus)
Creators: name: Landolfi, Jennifer A.
name: Gaffney, Patricia M.
name: McManamon, Rita
name: Gottdenker, Nicole L.
name: Ellis, Angela E.
name: Rech, Raquel R.
name: Han, Sushan
name: Lowenstine, Linda J.
name: Agnew, Dalen
name: Garner, Michael M.
name: McAloose, Denise
name: Hollinger, Charlotte
name: St. Leger, Judy
name: Terrell, Scott P.
name: Duncan, Mary
name: Pessier, Allan P.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine
subject: 70706 Veterinary Medicine
subject: FOS: Veterinary sciences

description: Supplemental Material, sj-pdf-1-vet-10.1177_03009858211031843 for Reproductive tract neoplasia in adult female Asian elephants (Elephas maximus) by Jennifer A. Landolfi, Patricia M. Gaffney, Rita McManamon, Nicole L. Gottdenker, Angela E. Ellis, Raquel R. Rech, Sushan Han, Linda J. Lowenstine, Dalen Agnew, Michael M. Garner, Denise McAloose, Charlotte Hollinger, Judy St. Leger, Scott P. Terrell, Mary Duncan and Allan P. Pessier in Veterinary Pathology
sj-pdf-1-smm-10.1177_09622802211023957 - Supplemental material for Variable selection for a mark-specific additive hazards model using the adaptive LASSO
Creators: name: Han, Dongxiao
name: Qu, Lianqiang
name: Sun, Liuquan
name: Sun, Yanqing
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111099 Nursing not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, sj-pdf-1-smm-10.1177_09622802211023957 for Variable selection for a mark-specific additive hazards model using the adaptive LASSO by Dongxiao Han, Lianqiang Qu, Liuquan Sun and Yanqing Sun in Statistical Methods in Medical Research
A real-world pharmacovigilance study of cardiac adverse events induced by sugammadex in the FDA adverse event reporting system
Creators: name: Lin, Xiao-Na
name: Zeng, You-Jie
name: Cao, Si
name: Jing, Xi-Bo
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Medicine
Cell Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Science Policy

description: Sugammadex is a novel agent that reverses neuromuscular blockade during general anesthesia. Recent case reports have raised concerns regarding potential cardiac adverse events (CAEs). However, no large-scale real-world studies have yet evaluated the potential link between sugammadex and CAEs. Data from the FDA Adverse Event Reporting System were obtained. The association between sugammadex and CAE was evaluated using reporting odds ratio, proportional reporting ratio, Bayesian confidence propagation neural network, and multi-item gamma Poisson shrinker methods. Serious outcomes resulting from sugammadex-related CAEs were assessed, and complications associated with CAEs were evaluated. Nineteen CAEs were identified and classified into two categories: cardiac arrhythmias and coronary artery disorders. The most frequent CAEs were bradycardia (n = 202), cardiac arrest (n = 119), tachycardia (n = 30), and Kounis syndrome (n = 22). Subgroup analysis based on age, sex, and weight revealed parallel findings. The CAEs most likely to result in serious consequences were pulseless electrical activity and cardiac arrest. The most common concurrent adverse effects with CAEs were hypotension (n = 51), anaphylactic reactions (n = 46), and anaphylactic shock (n = 23). This study suggests a potential link between sugammadex and CAEs, highlighting the need for careful monitoring and personalized risk assessment, especially in patients with cardiovascular risk factors.
What about the supervisor? The role of supervisor implicit person theory and behaviors in appraisal interviews
Creators: name: Drawbaugh, Montana Lyn
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Industrial and organisational psychology (incl. human factors)

description: Supervisors are the primary drivers of performance management; however, little is known about factors that influence their implementation of these systems. The purpose of this study was to investigate how a supervisor individual difference—implicit person theory (IPT)—differentially predicts supervisor behaviors during, as well as both supervisor and employee reactions to appraisal interviews. In Study 1, MBA students reported their supervisors’ behaviors during their most recent performance appraisal interview (Time 1) as well as their subsequent reactions (i.e., perceived satisfaction, utility, success, supervisor support; Time 2). Their supervisors completed a measure assessing their own IPT (Time 3). Findings suggest that supervisors’ task-oriented behaviors predicted perceived satisfaction, utility, and success of the appraisal interviews, while supervisor’ relational-oriented behaviors predicted perceived supervisor support. In Study 2, supervisors recruited via MTurk completed all measures from Study 1 except perceived success. Results suggest that IPT was positively related to task-oriented behaviors and perceived utility, task-oriented behaviors mediated the relationship between IPT and all three reaction measures (i.e., perceived satisfaction, utility, and supervisor support), and relational-oriented behaviors significantly predicted supervisors’ perceived support. Overall, findings suggest that supervisors who believe people can change (hold a more incremental IPT) display more task-oriented behaviors during and see more utility in appraisal interviews. Additionally, task-oriented behaviors emerged as the key mechanism linking supervisors’ IPT and reactions to appraisal interviews. These findings demonstrate that supervisor individual differences, such as IPT, can influence performance appraisal and management outcomes.
A real-world disproportionality analysis of FDA Adverse Event Reporting System (FAERS) events for ramucirumab
Creators: name: Lin, Li
name: Zheng, Xinlei
name: Wu, Min
name: Chen, Yan
name: Nian, Qichun
name: Lin, Yu
name: Chen, Maohua
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Ramucirumab (IMC-1121B) is a fully human immunoglobulin G1 monoclonal antibody, approved by the US Food and Drug Administration (FDA) for treating various cancers, including gastric, colorectal, liver, and non-small cell lung cancer. This study aimed to investigate the adverse events (AEs) associated with ramucirumab by utilizing data mining techniques on the FDA Adverse Event Reporting System (FAERS). We collected ramucirumab-related data from the FAERS database, spanning from January 2014 to June 2023. Our analysis incorporated both Frequentist and Bayesian methodologies in disproportionality analysis to determine the relationship between the drug and specific AEs. Among the 14,605,547 reports in FAERS database, 12,692,407 were identified as primary suspected AEs related to ramucirumab. These AEs involved 26 different organ systems, with 24 significant disproportionality Preferred Terms (PTs) identified across four algorithms. Notably, unexpected significant AEs, such as peripheral neuropathy, hemolytic uremic syndrome, rectal stenosis, anaphylactic shock, bladder tamponade, hydronephrosis, and spontaneous pneumothorax, were also observed. This study makes a significant contribution to the field by emphasizing the importance of long-term monitoring of approved agents to further expand on potential adverse events and to distinguish between events that are disease-related versus those more directly related to the particular treatment.
A real-world pharmacovigilance study of tafasitamab: data mining of the US food and drug administration adverse event reporting system
Creators: name: Xu, Zhongliang
name: Feng, Shimei
name: Huang, Dan
name: Wang, Hongli
name: Liu, Jiating
name: Shen, Zhengze
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: Tafasitamab is the first anti-CD19 monoclonal antibody approved for relapsed/refractory diffuse large B-cell lymphoma patients ineligible for autologous stem cell transplantation. The study was designed to evaluate tafasitamab-associated adverse events (AEs) by data mining the United States Food and Drug Administration Adverse Event Reporting System (FAERS). A disproportionality analysis was performed to assess the safety profile of tafasitamab based on the reports from the FAERS database between 2020Q3 and 2023Q3. Proportional reporting ratio (PRR) and empirical Bayesian geometric mean (EBGM) were used to identify the signals of AEs in patients receiving tafasitamab. A total of 529 reports with tafasitamab as the primary suspect drug were collected, including 1,262 AEs. Of these, 28 repeated AEs were identified using two algorithms. After excluding events unrelated to drug therapy, the top five repeated AEs by intensity ranking were cytopenia, immunosuppression, neutropenic sepsis, blood lactate dehydrogenase increased, and hematotoxicity. Unexpected significant AEs included polyneuropathy, splenomegaly, hemophagocytic lymphohistiocytosis, hypercalcemia, and ascites. This study provides additional evidence for risk identification of tafasitamab in the real world, which could help clinicians and pharmacists increase vigilance and improve the safety of tafasitamab in clinical practice.
Spotlight on measles 2010: Measles outbreak in a mainly unvaccinated community in Essen, Germany, March – June 2010
Creators: name: Roggendorf, Hedwig
name: Mankertz, Annette
name: Kundt, R.
name: Roggendorf, M.
Publisher: name: Robert Koch-Institut
Year: 2010
Subjects: subject: Adolescent
subject: Preschool
subject: Humans
subject: Female
subject: Disease Outbreaks
subject: Germany/epidemiology
subject: Male
subject: Child
subject: Infant
subject: Measles/epidemiology
subject: Schools
subject: Measles/prevention & control
subject: Immunization Programs
subject: Measles-Mumps-Rubella Vaccine/administration & dosage
subject: 610 Medizin

description: On 15 March 2010, a case of measles was reported to the District Health Office in Essen. In total 71 cases occurred from 15 March to 19 May (four cases hospitalised), with the majority linked to a Waldorf school. Only one case had been vaccinated twice, two cases had been vaccinated once. Immediate and consequent exclusion of non-immune children from classes for two weeks as well as the adjacent spring break prevented the wider spread of the virus.
A real-world disproportionality analysis of FDA adverse event reporting system (FAERS) events for ramucirumab
Creators: name: Lin, Li
name: Zheng, Xinlei
name: Wu, Min
name: Chen, Yan
name: Nian, Qichun
name: Lin, Yu
name: Chen, Maohua
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Ramucirumab (IMC-1121B) is a fully humanimmunoglobulin G1 monoclonal antibody, approved by the US Food and DrugAdministration (FDA) for treating various cancers, including gastric,colorectal, liver, and non-small cell lung cancer. This study aimed to investigatethe adverse events (AEs) associated with ramucirumab by utilizing data miningtechniques on the FDA Adverse Event Reporting System (FAERS). We collected ramucirumab-related data fromthe FAERS database, spanning from January 2014 to June 2023. Our analysisincorporated both Frequentist and Bayesian methodologies in disproportionalityanalysis to determine the relationship between the drug and specific AEs. Among the14,605,547 reports in FAERS database 12,692,407 were identified as primarysuspected AEs related to ramucirumab. These AEs involved 26 different organsystems, with 24 significant disproportionality Preferred Terms (PTs)identified across four algorithms. Notably, unexpected significant AEs, such asperipheral neuropathy, hemolytic uremic syndrome, rectal stenosis, anaphylacticshock, bladder tamponade, hydronephrosis, and spontaneous pneumothorax, werealso observed. This study makes a significant contributionto the field by emphasizing the importance of long-term monitoring of approvedagents to further expand on potential adverse events and to distinguish betweenevents that are disease-related versus those more directly related to theparticular treatment.
Additional file 1 of Screening and functional analysis of StMYB transcription factors in pigmented potato under low-temperature treatment
Creators: name: Chen, Bi-Cong
name: Wu, Xiao-Jie
name: Dong, Qiu-Ju
name: Xiao, Ji-Ping
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1.
sj-pdf-1-jcb-10.1177_0271678X211028816 - Supplemental material for Endovascular administration of magnetized nanocarriers targeting brain delivery after stroke
Creators: name: Grayston, Alba
name: Zhang, Yajie
name: Garcia-Gabilondo, Miguel
name: Arrúe, Mercedes
name: Martin, Abraham
name: Kopcansky, Peter
name: Timko, Milan
name: Kovac, Jozef
name: Strbak, Oliver
name: Castellote, Laura
name: Belloli, Sara
name: Moresco, Rosa M
name: Picchio, Maria
name: Roig, Anna
name: Rosell, Anna
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110305 Emergency Medicine
subject: FOS: Clinical medicine
subject: 110306 Endocrinology
subject: Medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: 110320 Radiology and Organ Imaging
subject: Cell Biology
subject: Biochemistry
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Neuroscience

description: Supplemental material, sj-pdf-1-jcb-10.1177_0271678X211028816 for Endovascular administration of magnetized nanocarriers targeting brain delivery after stroke by Alba Grayston, Yajie Zhang, Miguel Garcia-Gabilondo, Mercedes Arrúe, Abraham Martin, Peter Kopcansky, Milan Timko, Jozef Kovac, Oliver Strbak, Laura Castellote, Sara Belloli, Rosa M Moresco, Maria Picchio, Anna Roig and Anna Rosell in Journal of Cerebral Blood Flow & Metabolism
sj-pdf-1-cns-10.1177_11795735211029114 – Supplemental material for Salivary Heme Oxygenase-1: A Potential Biomarker for Central Neurodegeneration
Creators: name: Galindez, Julia M
name: Juwara, Lamin
name: Cressatti, Marisa
name: Gornitsky, Mervyn
name: Velly, Ana M
name: Schipper, Hyman M
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-1-cns-10.1177_11795735211029114 for Salivary Heme Oxygenase-1: A Potential Biomarker for Central Neurodegeneration by Julia M Galindez, Lamin Juwara, Marisa Cressatti, Mervyn Gornitsky, Ana M Velly and Hyman M Schipper in Journal of Central Nervous System Disease
Phosphodiesterase-5 inhibitors and hearing impairment: a disproportionality analysis using the US food and drug administration adverse event reporting system
Creators: name: Luo, Min
name: Liu, Tianqi
name: Ye, Xiangtong
name: Xiao, Bingjie
name: Gao, Ruonan
name: Cui, Ronghai
name: Wu, Bin
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Mental Health

description: This study aimed to investigate the association between phosphodiesterase-5 inhibitors (PDE-5i) and hearing impairment adverse events (HIAEs) while providing an overview of the characteristics of drug-related HIAEs. We conducted a detailed pharmacovigilance analysis using data from the US Food and Drug Administration Adverse Event Reporting System (FAERS) database, covering 2004 to 2022. By calculating the reporting odds ratio (ROR) and the information component (IC), we identified signals that indicate the association between PDE-5i use and HIAEs. Among the 191,398 reports related to PDE-5i, we identified 2,608 cases of HIAEs. Signals were observed for both PDE-5i monotherapy and polytherapy, indicating combinations of drugs. Avanafil exhibited the strongest signal (ROR: 4.35, 95% CI: 2.56–7.41, IC: 2.09, 95% CI: 0.10–3.51), while vardenafil showed the weakest signal (ROR: 2.69, 95% CI: 2.21–3.28, IC: 1.14, 95% CI: 0.74–2.04). Sildenafil had the highest reported cases (ROR: 3.03, 95% CI: 2.82–3.24, IC: 1.57, 95% CI: 1.34–1.80). These findings highlight a significant correlation between PDE-5i use and HIAEs, emphasizing the need for careful evaluation in clinical practice and providing appropriate guidance to patients before initiating treatment.
Phylogenetic history demonstrates two different lineages of dengue type 1 virus in Colombia
Creators: name: Mendez, Jairo A.
name: Usme-Ciro, Jose A.
name: Domingo, Cristina
name: Rey, Gloria J.
name: Sanchez, Juan A.
name: Tenorio, Antonio
name: Gallego-Gomez, Juan C.
Publisher: name: Robert Koch-Institut
Year: 2010
Subjects: subject: Molecular
subject: DNA
subject: Genetic
subject: Humans
subject: Phylogeny
subject: Genotype
subject: RNA
subject: Cluster Analysis
subject: Polymorphism
subject: Viral/genetics
subject: Sequence Analysis
subject: Molecular Epidemiology
subject: Viral Envelope Proteins/genetics
subject: Evolution
subject: Colombia/epidemiology
subject: Dengue/epidemiology
subject: Dengue/virology
subject: Dengue Virus/classification
subject: Dengue Virus/genetics
subject: Dengue Virus/isolation & purification
subject: 610 Medizin

description: Background: Dengue Fever is one of the most important viral re-emergent diseases affecting about 50 million people around the world especially in tropical and sub-tropical countries. In Colombia, the virus was first detected in the earliest 70′s when the disease became a major public health concern. Since then, all four serotypes of the virus have been reported. Although most of the huge outbreaks reported in this country have involved dengue virus serotype 1 (DENV-1), there are not studies about its origin, genetic diversity and distribution. Results: We used 224 bp corresponding to the carboxyl terminus of envelope (E) gene from 74 Colombian isolates in order to reconstruct phylogenetic relationships and to estimate time divergences. Analyzed DENV-1 Colombian isolates belonged to the formerly defined genotype V. Only one virus isolate was clasified in the genotype I, likely representing a sole introduction that did not spread. The oldest strains were closely related to those detected for the first time in America in 1977 from the Caribbean and were detected for two years until their disappearance about six years later. Around 1987, a split up generated 2 lineages that have been evolving separately, although not major aminoacid changes in the analyzed region were found. Conclusion: DENV-1 has been circulating since 1978 in Colombia. Yet, the phylogenetic relationships between strains isolated along the covered period of time suggests that viral strains detected in some years, although belonging to the same genotype V, have different recent origins corresponding to multiple re-introduction events of viral strains that were circulating in neighbor countries. Viral strains used in the present study did not form a monophyletic group, which is evidence of a polyphyletic origin. We report the rapid spread patterns and high evolution rate of the different DENV-1 lineages.
Die Korpora des Deutschen Textarchivs: Erfassung, Annotation, Analyse und Qualitätssicherung textbasierter Forschungsdaten für die Digital Humanities
Creators: name: Thomas, Christian
Publisher: name: Zenodo
Year: 2015
Subjects: 2015
Digital Humanities
Deutsches Textarchiv
Korpuslinguistik
Computerlinguistik
Annotation
XML

description: Im Vortrag werden Primärquellen, die über das DFG-geförderte Projekt „Deutsches Textarchiv“ (DTA, www.deutschestextarchiv.de) der Berlin-Brandenburgischen Akademie der Wissenschaften verfüg­bar gemacht wurden, und die vielfältigen Möglichkeiten zu deren Nutzung präsentiert. Das DTA umfasst derzeit knapp 2800 Dokumente mit mehr als 630 000 digitalisierten Seiten und ca. 1,1 Mrd. Zeichen (Stand: 7.10.2015). Neben dem Anspruch, vielseitig nutzbare und qualitativ hochwertige Primärquellen frei verfügbar zu machen, liegt der Fokus des DTA-Projekts auf der korpus- bzw. computerlinguistischen Analyse der elektronischen Volltexte. Alle Quellen stehen frei über das Internet in verschiedenen Formaten zum Herunterladen und auch zum ‚Harvesten‘ über eine API bereit (www.deutschestextarchiv.de/api).

Ein Schwerpunkt des Vortrags liegt auf einer allgemeineren Einführung in die Grundlagen XML-basierter Annotation von Volltexten entsprechend den Empfehlungen der Text Encoding Initiative bzw. dem darauf basierenden DTA-Basisformat (DTABf, www.deutschestextarchiv.de/doku/basisformat). Das DTABf bietet inklusive einer ausführlichen, mit Beispielen illustrierten Dokumentation alle notwendigen Voraussetzungen, um einen heterogenen Dokumentenbestand strukturell und semantisch zu annotieren.

Anschließend an diesen einführenden Teil stehen die vielfältigen Nutzungsmöglichkeiten solcher­maßen standardkonformer, plattformunabhängiger und (prinzipiell) interoperabler Textauszeichnung für die Publikation und computergestützte Analyse digitaler Editionen im Mittelpunkt. Anhand konkreter Beispiele aus der laufenden Kooperation des DTA mit dem Projekt „Hidden Kosmos: Reconstructing A. v. Humboldt’s »Kosmos-Lectures«“ (http://www.culture.hu-berlin.de/hidden-kosmos) liegt der Fokus auf der überlieferungsadäquaten Annotation und Edition handschriftlicher Dokumente. Im Projekt „Hidden Kosmos“ werden sämtliche derzeit bekannte Nachschriften zu Alexander von Humboldts weltberühmten Kosmos-Vorträgen (1827/28) erschlossen. Bis dato wurden bereits fünf vollständige, handschriftlich verfasste Nachschriften (Umfang: 2 100 Seiten) im DTA publiziert (siehe www.deutschestextarchiv.de/search/metadata?corpus=avhkv). Bis auf zwei Texte, die zuvor in gedruckten Editionen erschienen waren, kann der größte Teil dieser Nachschriften als der Forschung und der Allgemeinheit unbekannt gelten.

Nun können diese unikalen Manuskripte ortsunabhängig im DTA studiert, kommentiert, annotiert und heruntergeladen sowie mit Hilfe verschiedener DH-Werkzeugen analysiert werden. Im Vortrag wird unter anderem auf Gemeinsamkeiten und Unterschiede digitaler vs. traditioneller Editorik eingegangen. Der Vergleich der im DTA publizierten, tief strukturierten und annotierten Online-Volltexte mit den früheren Printeditionen macht die Vorzüge digitaler Editionen sichtbar.
Midwestern Anarchist Women Writers of the Nineteenth Century
Creators: name: Campbell, Michelle Marie
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: North American literature

description: Through examining the common themes in the writings of five anarchist women writers, I argue their writings are representative of ideological regionalism, or the convergence of factors that give rise to a political ideology that is then expounded through the literary production of a particular time and place. I analyze the economic, sexual, and “religious” politics across fiction, non-fiction, and poetry, connecting arguments about class, individualism, feminism, and anarchism to a foundation of Midwestern cultural ideology. Ultimately, I argue that economic, political, and historical conditions promulgated an exceptionalist American anarchism rooted in settler anti-statism.
High Theory Podcast Invitation
Creators: name: Adams, Kim
name: Bosu, Saronik
Publisher: name: unknown
Year: 2021
Subjects: subject: Politics and government
subject: Societies
subject: Critical theory
subject: Criticism
subject: Interdisciplinary approach to knowledge
subject: Aesthetics

description: High Theory is a podcast that takes on difficult ideas from the academy with irreverence. We invite you to join us for a MLA happy hour on Saturday January 9, from 7-8pm. We would love to hear your podcast ideas! Email us at info@hightheory.net or RSVP for a Zoom link on our website hightheory.net
MULTILINGUAL CYBERBULLYING DETECTION SYSTEM
Creators: name: Pawar, Rohit Sidram
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Software engineering not elsewhere classified
Digital processor architectures
Other information and computing sciences not elsewhere classified
Distributed computing and systems software not elsewhere classified
Knowledge representation and reasoning
Natural language processing

description: Since the use of social media has evolved, the ability of its users to bully others has increased. One of the prevalent forms of bullying is Cyberbullying, which occurs on the social media sites such as Facebook©, WhatsApp©, and Twitter©. The past decade has witnessed a growth in cyberbullying – is a form of bullying that occurs virtually by the use of electronic devices, such as messaging, e-mail, online gaming, social media, or through images or mails sent to a mobile. This bullying is not only limited to English language and occurs in other languages. Hence, it is of the utmost importance to detect cyberbullying in multiple languages. Since current approaches to identify cyberbullying are mostly focused on English language texts, this thesis proposes a new approach (called Multilingual Cyberbullying Detection System) for the detection of cyberbullying in multiple languages (English, Hindi, and Marathi). It uses two techniques, namely, Machine Learning-based and Lexicon-based, to classify the input data as bullying or non-bullying. The aim of this research is to not only detect cyberbullying but also provide a distributed infrastructure to detect bullying. We have developed multiple prototypes (standalone, collaborative, and cloud-based) and carried out experiments with them to detect cyberbullying on different datasets from multiple languages. The outcomes of our experiments show that the machine-learning model outperforms the lexicon-based model in all the languages. In addition, the results of our experiments show that collaboration techniques can help to improve the accuracy of a poor-performing node in the system. Finally, we show that the cloud-based configurations performed better than the local configurations.
Dupilumab induced ocular surface diseases: an analysis of FAERS database, literature review and disease–gene interaction networks
Creators: name: Chen, Jiaojiao
name: Li, Huixiang
name: Zhang, Huiyuan
name: ShenTu, Qiaoqiao
name: Wang, Shaoxia
name: Zhao, Quan
name: Wang, Yinglin
name: Wang, Fei
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Cell Biology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Adverse events (AE) in dupilumab-induced ocular surface diseases (DIOSD) have raised concerns regarding its safety. The objective of this study was to evaluate DIOSD by employing database analysis and clinical case review, along with mechanism analysis. Database AE data were extracted from FAERS from 2017 Quarter 1 (Q1) to 2023 Q1. Disproportionality analyses were performed to identify the risk signals associated with DIOSD. Case reports/case series reported on DIOSD from March 2017 to June 2023 were collected for a literature review. The mechanisms of DIOSD were investigated through disease–gene interaction network analysis. A total of 85 signals related to DIOSD were detected from FAERS. The most reported AE was ‘dry eye’ (n = 3503, ROR 20.32, 95% CI: 19.53–21.14). There were 36 articles, including 201 cases showing the evidence of DIOSD, with an average age of 43 years. About 64.18% patients suffered from severe atopic dermatitis, and 48.26% were reported with a previous ocular history. The mechanisms study suggested that tumor necrosis factor plays an important role in DIOSD. Our findings support that dupilumab use is associated with exacerbation or new-onset OSD. Particular attention should be focused on eye symptoms during dupilumab use.
sj-docx-1-emr-10.1177_17540739211022815 – Supplemental material for Horror Films and Grief
Creators: name: Millar, Becky
name: Lee, Jonny
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Anthropology
subject: FOS: Sociology
subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: Sociology

description: Supplemental material, sj-docx-1-emr-10.1177_17540739211022815 for Horror Films and Grief by Becky Millar and Jonny Lee in Emotion Review