cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Compensating for literature annotation bias when predicting novel drug-disease relationships through Medical Subject Heading Over-representation Profile (MeSHOP) similarity
Creators: name: Cheung, Warren A.
name: Ouellette, B. F. F.
name: Wasserman, Wyeth W.
Publisher: name: BioMed Central
Year: 2016

description: Background: Using annotations to the articles in MEDLINE®/PubMed®, over six thousand chemical compounds with pharmacological actions have been tracked since 1996. Medical Subject Heading Over-representation Profiles (MeSHOPs) quantitatively leverage the literature associated with biological entities such as diseases or drugs, providing the opportunity to reposition known compounds towards novel disease applications. Methods: A MeSHOP is constructed by counting the number of times each medical subject term is assigned to an entity-related research publication in the MEDLINE database and calculating the significance of the count by comparing against the count of the term in a background set of publications. Based on the expectation that drugs suitable for treatment of a disease (or disease symptom) will have similar annotation properties to the disease, we successfully predict drug-disease associations by comparing MeSHOPs of diseases and drugs. Results: The MeSHOP comparison approach delivers an 11% improvement over bibliometric baselines. However, novel drug-disease associations are observed to be biased towards drugs and diseases with more publications. To account for the annotation biases, a correction procedure is introduced and evaluated. Conclusions: By explicitly accounting for the annotation bias, unexpectedly similar drug-disease pairs are highlighted as candidates for drug repositioning research. MeSHOPs are shown to provide a literature-supported perspective for discovery of new links between drugs and diseases based on pre-existing knowledge.
Simulation data: Terahertz-driven controllable molecular isomerization
Creators: name: Zhu, Zhi
Publisher: name: Zenodo
Year: 2025

description: This repository contains the data generated in this study, including system setups, force field parameters, and GROMACS input files used in our paper Terahertz-Driven Controllable Molecular Isomerization, currently under peer review at Nature Communications.
When investigating depression and anxiety in undergraduate medical students timing of assessment is an important factor - a multicentre cross-sectional study.
Creators: name: Thiemann, Pia
name: Brimicombe, James
name: Benson, John
name: Quince, Thelma
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Depression
Anxiety
Undergraduate Medical Students
Final Exams
Timing Of Assessment

description: BACKGROUND:Symptoms of depression and anxiety experienced by undergraduate medical students have become a prominent concern. Evidence about students' depression and anxiety including prevalence, trajectory during medical education, gender differences and comparisons with age-matched peers is conflicting. However few studies of medical students' mental health specify the precise time of assessment. Proximity to examinations may be relevant. Precise identification of the time of data collection might help explain contradictory findings and facilitate provision of more timely support. METHODS:This study addressed whether: 1)Proximity of final examinations affected students' depression and anxiety symptoms2)Males and females differed in this respect. We analysed data provided by 446 final year students from 6 UK medical schools. These students were a subset of data provided by 14 UK medical schools which participated in an online survey comparing first and final year students and in which final year response rates exceeded 30%. We used the Hospital Anxiety and Depression Scale to assess symptoms of depression and anxiety and the norms to indicate potentially clinically relevant cases. We grouped students into those for whom final exams were imminent i.e. within 2 months of completing the survey (n = 164) and those for whom exams were more distant or had been taken (n = 282). We used parametric and non-parametric tests to compare both groups and gender differences in respect of depression and anxiety sum scores and cases rates. RESULTS:For both depression and anxiety male and female students facing imminent final exams recorded greater prevalence and significantly higher mean scores. The effect size of differences for anxiety were large. No substantial gender differences were found for depression. Regardless of the timing of final exams female students recorded both significantly higher mean scores and clinically relevant rates for anxiety. CONCLUSIONS:Proximity to final exams negatively affected the mental health of both male and female final year students. The study suggests that there may be times in the undergraduate medical curriculum when additional or targeted support is needed. It also highlights the need for research to provide a greater specificity of context when investigating medical students' mental health.
Pengaruh Indeks Pembangunan Gender dan Tingkat Partisipasi Angkatan Kerja Terhadap Produk Domestik Regional Bruto Seluruh Kabupaten di Provinsi Sumatera Barat Tahun 2019-2023
Creators: name: Yulia Leni Fitria Sari¹, Tartila Devy2
Publisher: name: Zenodo
Year: 2025

description:
Soziale Marktwirtschaft als Modell für die zukünftige Wirtschaftsordnung Chinas?
Creators: name: Taube, Markus
Publisher: name: Internationales Asienforum
Year: 2017

description: This article maintains that the transformation process in the People's Republic of China is at the crossroads. Now that the foundations for a free enterprise system have been laid, the task for the coming years is to eliminate the regulatory fragmentation of the national economy in regions in which experiments with specific regulatory models have been conducted. Of all the various free enterprise systems, the model of a social market economy as originally conceived by L. Erhard and A. Müller-Armack could be taken as a guideline. First reports of mass worker unrest in China show all too clearly that economic and social reforms in China can only be successfully continued if the resulting social hardships can be cushioned by social policies. In order to implement the symbiosis in a social market economy between rapid economic growth and social equilibrium, far-reaching measures towards a workable system of competition law and a social insurance system based on the subsidiarity principle must be undertaken.
description: Internationales Asienforum, Bd. 29 Nr. 1-2 (1998): Internationales Asienforum
Nationalwahlen in Papua-Neuguinea 1997
Creators: name: Krüger, Coerw
Publisher: name: Internationales Asienforum
Year: 2017

description: Papua New Guinea (PNG) stretches eastward on the huge, bird-shaped island of New Guinea, which lies north of Australia. After British and German colonial rule, followed by Australian administration, PNG achieved independence in 1975. PNG inherited the Westminster Model of parliamentary democracy, and it is among the few countries of the Third World in which democratic patterns persisted without interruption or serious threat despite some social and political problems. Free elections are not the only, but an essential criterion for a functioning democratic system. The first free national election in PNG's postcolonial history was held in 1977. In 1997, about 3.2 million Papua New Guineans participated in the fifth parliamentary election since independence. With reference to the 1997 election this essay outlines the cultural, social, and political issues that accompany the realisation of democratic principles in PNG.
description: Internationales Asienforum, Bd. 29 Nr. 1-2 (1998): Internationales Asienforum
A brief tool to assess capacity to consent for medical care among homeless individuals with problematic substance use: study protocol
Creators: name: Taylor, Darlene
name: Mâsse, Louise C.
name: Ho, Anita
name: Rekart, Michael L.
name: Tyndall, Mark
name: Henry, Bonnie
name: Clifton, Joanne
name: Peters, Laurenna
name: Ogilvie, Gina
name: Buxton, Jane A.
Publisher: name: BioMed Central
Year: 2015

description: Background: Public health care increasingly uses outreach models to engage individuals who are marginalized, many of whom misuse substances. Problematic substance use, together with marginalization from the health care system, among homeless adults makes it difficult to assess their capacity to consent to medical care. Tools have been developed to assess capacity to consent; however, these tools are lengthy and unsuitable for outreach settings. The primary objective of this study is to develop, validate, and pilot a brief but sensitive screening instrument which can be used to guide clinicians in assessing capacity to consent in outreach settings. The goal of this paper is to outline the protocol for the development of such a tool. Methods/Design A brief assessment tool will be developed and compared to the MacArthur Competency Assessment Tool for Treatment (MacCAT-T). As list of 36 possible questions will be created by using qualitative data from clinician interviews, as well as concepts from the literature. This list will be rated by content experts according to the extent that it corresponds to the test objectives. The instrument will be validated with 300 homeless adult volunteers who self-report problematic substance use. Participants will be assessed for capacity using the MacCAT-T and the new instrument. A combination of Classical Test Theory and advanced psychometric methods will be used for the psychometric analysis. Corrected Item-Total correlation will be examined to identify items that discriminate poorly. Guided exploratory factor analysis will be conducted on the final selection of items to confirm the assumptions for a unidimensional polytomous Rasch model. If unidimensionality is confirmed, an unstandardized Cronbach Alpha will be calculated. If multi-dimensionality is detected, a multidimensional Rasch analysis will be conducted. Results from the new instrument will be compared to the total score from the MacCAT-T by using Pearson’s correlation test. The new instrument will then be piloted in real-time by street outreach clinicians to determine the acceptability and usefulness of the new instrument. Discussion This research will build on the existing knowledge about assessing capacity to consent and will contribute new knowledge about assessing individuals whose judgment is impaired by substance use.
A direct role for SNX9 in the biogenesis of filopodia.
Creators: name: Jarsch, Iris K
name: Gadsby, Jonathan R
name: Nuccitelli, Annalisa
name: Mason, Julia
name: Shimo, Hanae
name: Pilloux, Ludovic
name: Marzook, Bishara
name: Mulvey, Claire M
name: Dobramysl, Ulrich
name: Bradshaw, Charles R
name: Lilley, Kathryn S
name: Hayward, Richard D
name: Vaughan, Tristan J
name: Dobson, Claire L
name: Gallop, Jennifer L
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020

description: Filopodia are finger-like actin-rich protrusions that extend from the cell surface and are important for cell-cell communication and pathogen internalization. The small size and transient nature of filopodia combined with shared usage of actin regulators within cells confounds attempts to identify filopodial proteins. Here, we used phage display phenotypic screening to isolate antibodies that alter the actin morphology of filopodia-like structures (FLS) in vitro. We found that all of the antibodies that cause shorter FLS interact with SNX9, an actin regulator that binds phosphoinositides during endocytosis and at invadopodia. In cells, we discover SNX9 at specialized filopodia in Xenopus development and that SNX9 is an endogenous component of filopodia that are hijacked by Chlamydia entry. We show the use of antibody technology to identify proteins used in filopodia-like structures, and a role for SNX9 in filopodia.
Marginality then and now: Shifting Patterns of Minority Status in Brunei Darussalam
Creators: name: Kershaw, Roger
Publisher: name: Internationales Asienforum
Year: 2017

description: Present-day Brunei has been able to survive as a micro-state thanks to oil. But its wealth has also proved consolidating with regard to political structure, including ethnic stratification. Chinese and Ibans have been accorded grossly inferior status, by comparison with their counterparts in Malaysia, owing partly to the distinctive evolution of nationalism and monarchy in the two countries. Even the seven recognised indigenous groups are differentiated on the basis of religion. But more significant is the threat to the very survival of non-Muslim cultures from assimilationist pressures in an authoritarian Malay polity.
description: Internationales Asienforum, Bd. 29 Nr. 1-2 (1998): Internationales Asienforum
A Mediterranean Diet Is Positively Associated with Bone and Muscle Health in a Non-Mediterranean Region in 25,450 Men and Women from EPIC-Norfolk.
Creators: name: Jennings, Amy
name: Mulligan, Angela A
name: Khaw, Kay-Tee
name: Luben, Robert N
name: Welch, Ailsa A
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Muscle
Fracture
Mediterranean Diet

description: Research on Mediterranean diet (MD) adherence and musculoskeletal health is limited. The current study determined if adherence to the alternative MD score (aMED) and MD score (MDS), quantified from 7-d food diaries, was associated with fracture incidence, bone density (calcaneal broadband ultrasound attenuation (BUA)) and fat free mass (expressed over BMI (FFMBMI) using bioelectrical impedance) in 25,450 men and women recruited to the European Prospective Investigation into Cancer study in Norfolk, UK. During 17.4 years of follow up (443,178 total person years) 2195 incident fractures occurred. Higher aMED adherence was associated with 23% reduced total (Q5-Q1 HR 0.77; 95% CI 0.67, 0.88; p-trend < 0.01) and 21% reduced hip (Q5-Q1 HR 0.79; 95% CI 0.65, 0.96; p-trend = 0.01) fracture incidence, and significantly higher BUA (Q5-Q1 1.0 dB/MHz 95% CI 0.2, 1.9; p-trend < 0.01) and FFMBMI (Q5-Q1 0.05 kg/(kg/m2) 95% CI 0.04, 0.06; p-trend < 0.01), comparing extreme adherence quintiles. Higher MDS was also associated with reduced total fractures (Q5-Q1 HR 0.83; 95% CI 0.71, 0.96; p-trend = 0.03) and significantly higher BUA (Q5-Q1 1.4 dB/MHz 95% CI 0.5, 2.3; p-trend < 0.01) and FFMBMI (Q5-Q1 0.03 kg/(kg/m2) 95% CI 0.01, 0.04; p-trend < 0.01). This evidence supports the need to develop interventions to enhance MD adherence, particularly in women, where evidence for associations was stronger.
Experimental Effects of Acute High-Intensity Resistance Exercise on Episodic Memory Function: Consideration for Post-Exercise Recovery Period.
Creators: name: Loprinzi, Paul D
name: Green, David
name: Wages, Shelby
name: Cheke, Lucy G
name: Jones, Timothy
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Encoding
Physical Activity
Consolidation
Memory Function

description: Background:The present experiments evaluated the effects of acute high-intensity resistance exercise on episodic memory. Methods:Two experiments were conducted. For Experiment 1, participants (N = 40; Mage = 21.0 years) were randomized into one of two groups, including an experimental exercise group and a control group (seated for 20 min). The experimental group engaged in an acute bout of resistance exercises (circuit style exercises) for 15 minutes, followed by a 5-min recovery period. Memory function was subsequently assessed using a multiple trial (immediate and delay), word-list episodic memory task (Rey Auditory Verbal Learning Test, RAVLT), and then followed by a comprehensive, computerized assessment of episodic memory (Treasure Hunt task, THT). The THT involved a spatio-temporal assessment of what, where, and when components of episodic memory. Experiment 2 evaluated if altering the recovery period would influence the potential negative effects of high-intensity resistance exercise on episodic memory function. For Experiment 2, participants (N = 51) were randomized into the same acute resistance exercise protocol but either with a 10-min recovery period, 20-min recovery period, or a control group. Results:For Experiment 1, for RAVLT, the exercise group performed worse (Fgroup × time = 3.7, p = .001, η 2p = .09). Across nearly all THT outcomes, the exercise group had worse spatio-temporal memory than the control group. These results suggest that high-intensity resistance exercise (with a 5-min recovery) may have a detrimental effect on episodic memory function. For Experiment 2, for RAVLT, the exercise with 10-min recovery group performed better (Fgroup × time = 3.1, p = .04, η 2p = .11). Unlike Experiment 1, exercise did not impair spatio-temporal memory, with the 20-min exercise recovery group having the best "where" component of episodic memory. Conclusion:Collectively, the results from these two experiments suggest that acute high-intensity resistance exercise may impair episodic memory when a short exercise recovery period (e.g., 5-min) is employed, but with a longer recovery period (10+ min), acute high-intensity resistance exercise may, potentially, enhance episodic memory.
Wirtschaftlicher Wandel und Computerisierung in Singapur. Die Rolle des 'starken' Staates im Prozeß ökonomischer Restrukturierung
Creators: name: Jordan, Rolf
Publisher: name: Internationales Asienforum
Year: 2017

description: The economic success of the Newly Industrializing Countries in the Asian- Pacific region has been a much discussed topic in recent years. Singapore’s economic development is just one good example of this ‘success story’. Here we deal with the role of strong governmental policies in the process of restructuring Singapore’s economy from an export processing platform for labour-intensive mass-production to a modem industrial economy and an advanced service-hub for the region. The dominant role of the state is the driving force behind Singapore’s transformation into an advanced ‘Information Society’. This article describes the implementation of several IT- plans by the government starting from the first ‘Strategic IT Plan’ in 1980 to the TT2000’ masterplan of the mid-1990’s to make Singapore an Intelligent Island for the next millennium. Problems resulting from these developmental policies are discussed in this context, especially those concerning the competitiveness of domestic enterprises and the continuous scarcity of local IT professionals.
description: Internationales Asienforum, Bd. 29 Nr. 1-2 (1998): Internationales Asienforum
Intraregional Disparities in Northeastern Thailand. A contribution to the internal differentiation of a peripheral region
Creators: name: Reuber, Paul
Publisher: name: Internationales Asienforum
Year: 2017

description: With the lowest population density and the highest percentage of agricultural households Isan lies economically far behind the core areas of Thailand. Internal analysis, however, shows that the region is by no means as homogeneous as the externally oriented perspective seems to reflect. Rather, the area shows intraregional disparities whose relative scale is likewise considerable. A small-scale comparison on the level of the amphoe (districts) reveals a spatial pattern of different subregions whose organisation follows a central-peripheral and a point-axial principle. It clarifies three types of subregions between which broad transitional zones are to be found. Agro-economic possibilities and the modem transport infrastructure thereby form the two fundamental determinants of this internal regional differentiation in Isan.
description: Internationales Asienforum, Bd. 29 Nr. 1-2 (1998): Internationales Asienforum
The NTR Phenomenon Reconsidered
Creators: name: Neuss, Jürgen
Publisher: name: Internationales Asienforum
Year: 2017

description: The death of the former chief minister of Andhra Pradesh, Nandamuri Taraka Rama Rao, marked the end of a period during which the state's political landscape was determined largely by his personality and charisma. This contribution summarizes NTR's political career in the state and his significance for the formation of a joint national opposition to the Congress®, as well as the development of his party, the Telugu Desham, which resulted in its establishment as the most important political force besides the Congress® in Andhra Pradesh. At the same time it describes the ascent of Naravirapalli Chandrababu Naidu, NTR's son-in-law and the present chief minister of Andhra Pradesh, who took over the party leadership after he initiated a crucial split of the party in 1995, shortly before NTR's death.
description: Internationales Asienforum, Bd. 29 Nr. 1-2 (1998): Internationales Asienforum
Autismussensible Förderung sozialer Basiskompetenzen. Entwicklung einer Spiele-Kartei für den sonderpädagogischen Kontext
Creators: name: Mühlebach, Marion
Publisher: name: Interkantonale Hochschule für Heilpädagogik
Year: 2024
Subjects: Sonderpädagogik
Masterarbeit
Autismus
Förderung
Basiskompetenz
Spiele

description: In der vorliegenden Masterarbeit wird der Frage nach gegangen welche Elemente aus vier bewährten, autismusspezifischen Sozialkompetenz-Förderprogrammen auch in einer gemischten Lerngruppe im sonderpädagogischen Kontext effektiv eingesetzt werden können. Dazu werden die theoretischen Grundlagen zu Autismus dargelegt sowie die vier Sozialkompetenzprogramme einander gegenübergestellt und analysiert. Geeignete Übungen zu den Themen Wahrnehmung, Emotion und Interaktion werden zu einer systematisch geordneten Spiele-Kartei zusammengeführt. Die erarbeitet Spiele-Kartei hat zum Ziel, Lehrpersonen bei der Förderung der sozialen Basiskompetenzen zu unterstützen. Zudem geht hervor, dass der schulische Kontext ein wichtiger Faktor für eine gelingende Generalisierung darstellt, da die Fördermassnahmen in ein Gesamtkonzept eingebettet sind.
Politics of Transformation and Ismailis in Gorno-Badakhshan, Tajikistan
Creators: name: Emadi, Hafizullah
Publisher: name: Internationales Asienforum
Year: 2017

description: This paper examines the process of societal development in the former Soviet republic of Tajikistan prior to and during the era of socialist construction in the early 1930s and 1940s. It studies the basis of a shift from popular-based participatory development to a bureaucratic and top-down approach to societal transformation in the 1950s and onward until the demise of the Soviet imperial power and the emergence of the independent republic of Tajikistan. A major focus is the argument that bureaucratization of state and society in Tajikistan in the 1960s and 1970s led to the emergence of anti-establishment discourse as seen in the increasing Islamization in the 1980s and subsequent armed clashes between defenders of the status quo and those of privatization and market economy in the 1990s. The war which resulted in the collapse of administrative and economic activities in Tajikistan, particularly in the Gorno-Badakhshan region, attracted international attention. This paper also analyzes the role of the Aga Khan Development Network (AKDN) in the process of reconstruction, privatization and integration of Gorno- Badakhshan into the world community in the twenty-first century.
description: Internationales Asienforum, Bd. 29 Nr. 1-2 (1998): Internationales Asienforum
Solution Processable Functional Polymers
Creators: name: Ahmed, Mustafa Humbel
Publisher: name: Purdue University Graduate School
Year: 2024
Subjects: classificationCode: 401609
subject: Polymers and plastics
classificationCode: 340599
subject: Organic chemistry not elsewhere classified

description: First, we aimed to incorporate stable tetracyanocyclopentadienide (TCCp) aromatic ani­ons into polynorbornene-based electrolytes, emphasizing controlled synthesis and properties through ring-opening metathesis polymerization (ROMP). Here, we first successfully incorporate a stable tetracyanocyclopentadienide (TCCp) aromatic anion into polynorbornene (PNb)-based elec­trolytes (PNb-TCCp) through ring-opening metathesis polymerization (ROMP) with controllable molecular weight and low polydispersity. PNb-TCCp shows a high ionic conductivity of 4.5 × 10–5 S/cm in thin films. Due to its highly stable aromatic anion groups and favorable interactions with aromatic cations, it could improve thermal stability of doped conjugated polymers. Pairing with doped poly(3,4-ethylenedioxythiophene) (PEDOT) through salt metathesis, the generated poly ion complex PEDOT:PNb-TCCp retains its conductivity up to 180 °C.Second, we aim to develop new photocatalysts for O-ATRP. We discovered a novel one-pot synthetic approach elu­cidates the formation of core-extended N,N′-disubstituted diaryl dihydrophenazine diradical dica­tions (DRDCs) via chemical oxidation. These DRDCs were reduced to their neutral state and found to have photocatalytic abilities, expanding the knowledge for O-ATRP photocatalysts.Finally, we aim to understand the fundamental structure property relationship of the n-doped n-PBDF. The n-doped poly(benzodifurandione) (n-PBDF) is an n-type conducting polymer with characteristics such as high electrical conductivity, solution processability, and weathering stability. Here, we sys­tematically in­vestigate the structure property relationship on the impact of structural mod­ifications through aromatic substitution on the photophysical, electrical, and structural properties of n-PBDF and its oligomeric derivatives. We demonstrated that an electron donation group (methyl) raised the highest occupied molecular orbital energy level (+0.15 eV), while electron withdrawing halogens (Br and Cl) decreased the lowest unoccupied molecular orbital energy level (−0.12 eV and −0.13 eV, respectively) in the polymers. Additionally, in the both the undoped and doped oligo­meric systems, these substitutions introduce large torsion angles (θ > 17°), causing the material to twist significantly. Moreover, the methyl substituted polymer, n-PBDF-Me, was evaluated for its potential as a transparent organic conductor, due to its high optical transmittance (T550 > 93%). However, n-PBDF-Me films have significantly lower con­ductiv­ity than n-PBDF (0.40 S/cm vs 1330 S/cm) at similar thickness.
Neurovascular Coupling of the Posterior Cerebral Artery in Spinal Cord Injury: A Pilot Study
Creators: name: Phillips, Aaron A.
name: Krassioukov, Andrei V.
name: Zheng, Mei Mu Zi
name: Warburton, Darren E. R.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Purpose: To compare neurovascular coupling in the posterior cerebral artery (PCA) between those with spinal cord injury (SCI) and able bodied (AB) individuals. Methods: A total of seven SCI and seven AB were matched for age and sex. Measures included PCA velocity (PCAv), beat-by-beat blood pressure and end-tidal carbon dioxide. Posterior cerebral cortex activation was achieved by 10 cycles of (1) 30 s eyes closed (pre-stimulation), (2) 30 s reading (stimulation). Results: Blood pressure was significantly reduced in those with SCI (SBP: 100 ± 13 mmHg; DBP: 58 ± 13 mmHg) vs. AB (SBP: 121 ± 12 mmHg; DBP: 74 ± 9 mmHg) during both pre-stimulation and stimulation, but the relative increase was similar during the stimulation period. Changes in PCAv during stimulation were mitigated in the SCI group (6% ± 6%) vs. AB (29% ± 12%, P < 0.001). Heart rate and end-tidal carbon dioxide responded similarly between groups. Conclusions: Clearly, NVC is impaired in those with SCI. This study may provide a link between poor perfusion of the posterior cerebral region (containing the medullary autonomic centres) and autonomic dysfunction after SCI.
“Crisis Management - Chinese Entrepreneurs and Business Networks in Southeast Asia”, Bonn, May 28-30, 1999
Creators: name: Gerke, Solvay
name: Evers, Hans-Dieter
name: Menkhoff, Thomas
Publisher: name: Internationales Asienforum
Year: 2017

description: Internationales Asienforum, Bd. 30 Nr. 3-4 (1999): Internationales Asienforum
Unfallverletzungen im Kindes- und Jugendalter – Prävalenzen, Unfall- und Behandlungsorte, Mechanismen
Creators: name: Saß, Anke-Christine
name: Kuhnert, Ronny
name: Gutsche, Johanna
Publisher: name: Robert Koch-Institut
Year: 2019
Subjects: subject: Kinder
subject: Jugendliche
subject: Unfälle
subject: Verletzungen
subject: Gesundheitssurvey
subject: 610 Medizin und Gesundheit

description: Hintergrund Unfallverletzungen zählen zu den häufigsten Gesundheitsproblemen im Kindes- und Jugendalter. Informationen über die Verteilung und zeitliche Veränderung von Unfallhäufigkeiten sind eine wichtige Grundlage für die Unfallprävention. Die zweite Folgebefragung der Studie zur Gesundheit von Kindern und Jugendlichen in Deutschland (KiGGS Welle 2, 2014–17) ermöglicht eine Fortsetzung des mit der KiGGS-Basiserhebung (2003–06) begonnenen Monitorings nichttödlicher Unfallverletzungen auf Bundesebene. Methode KiGGS Welle 2 ist eine bundesweite Quer- und Längsschnitterhebung des Robert Koch-Instituts (RKI); an der Querschnittserhebung nahmen 15.023 0‑ bis 17-Jährige teil (Response: 40,1 %). Die Eltern wurden schriftlich befragt, u. a. nach unbeabsichtigten Verletzungen ihrer Kinder. Informationen zu Unfällen liegen von 2429 Kindern und Jugendlichen vor (1–17 Jahre). Es wurden 12-Monats-Prävalenzen mit 95 %-KI berechnet und Vergleiche zu den vorherigen KiGGS-Erhebungen angestellt. Ergebnisse 16,5 % der 1‑ bis 17-Jährigen wurden innerhalb von 12 Monaten wegen eines Unfalls ärztlich behandelt, Jungen (18,6 %) signifikant häufiger als Mädchen (14,3 %). 4,8 % hatten drei oder mehr Ereignisse. Jedes achte verunfallte Kind blieb mindestens eine Nacht im Krankenhaus (12,4 %). Die Unfälle passierten am häufigsten zu Hause, in Bildungs- und Betreuungseinrichtungen sowie auf dem Spielplatz/in Sporteinrichtungen. Schlussfolgerung Verletzungsrisiken im Kindes- und Jugendalter variieren v. a. nach Alter und Geschlecht, aber z. B. auch nach personen- und umweltbezogenen Faktoren. Das Wissen über solche Kontextbedingungen ist für die Entwicklung von Präventionsmaßnahmen bedeutsam. Seit Beginn der KiGGS-Studie sind kaum Veränderungen und insgesamt kein Rückgang bei den Unfallverletzungen im Kindes- und Jugendalter zu verzeichnen.
THOMAS HEBERER, WOLFGANG TAUBMANN, unter Mitarbeit von FAN JIE, FAN GONHZENG und ZHU HONGXING: Chinas ländliche Gesellschaft im Umbruch - Urbanisierung und sozio-ökonomischer Wandel auf dem Lande
Creators: name: Bergmann, Theodor
Publisher: name: Internationales Asienforum
Year: 2017

description: Internationales Asienforum, Bd. 30 Nr. 3-4 (1999): Internationales Asienforum
THOMAS SCHARPING / SUN HUAIYANG (eds.): Migration in China’s Guangdong Province. Major Results of a 1993 Sample Survey on Migrants and Floating Population in Shenzhen and Foshan; THOMAS SCHARPING (ed.): Floating Population and Migration in China. The Impact of Economic Reforms
Creators: name: Wüllner, Claudia
Publisher: name: Internationales Asienforum
Year: 2017

description: Internationales Asienforum, Bd. 30 Nr. 3-4 (1999): Internationales Asienforum
STEVEN WEDEMA: “Ethiek” und Macht. Die niederländisch-indische Kolonialverwaltung und indonesische Emanzipationsbestrebungen 1901-1927
Creators: name: Houben, Vincent
Publisher: name: Internationales Asienforum
Year: 2017

description: Internationales Asienforum, Bd. 30 Nr. 3-4 (1999): Internationales Asienforum
Between journals and archives: peer reviewing and other possible futures for academic publishing
Creators: name: Thomas, Julian
Publisher: name: Swinburne
Year: 2024

description: Over the last decade, an extraordinary array of new online archives for academic research has appeared. Never has so much scholarship been so readily accessible. But the new online archives also have the potential to change the nature of scholarship. They raise questions over the business of academic publishing and the processes that sustain it: these are the themes of the discussion that follows.
Sequencing platform and library preparation choices impact viral metagenomes
Creators: name: Solonenko, Sergei A
name: Ignacio-Espinoza, J C
name: Alberti, Adriana
name: Cruaud, Corinne
name: Hallam, Steven
name: Konstantinidis, Kostas
name: Tyson, Gene
name: Wincker, Patrick
name: Sullivan, Matthew B
Publisher: name: BioMed Central
Year: 2015

description: Background: Microbes drive the biogeochemistry that fuels the planet. Microbial viruses modulate their hosts directly through mortality and horizontal gene transfer, and indirectly by re-programming host metabolisms during infection. However, our ability to study these virus-host interactions is limited by methods that are low-throughput and heavily reliant upon the subset of organisms that are in culture. One way forward are culture-independent metagenomic approaches, but these novel methods are rarely rigorously tested, especially for studies of environmental viruses, air microbiomes, extreme environment microbiology and other areas with constrained sample amounts. Here we perform replicated experiments to evaluate Roche 454, Illumina HiSeq, and Ion Torrent PGM sequencing and library preparation protocols on virus metagenomes generated from as little as 10pg of DNA. Results Using %G + C content to compare metagenomes, we find that (i) metagenomes are highly replicable, (ii) some treatment effects are minimal, e.g., sequencing technology choice has 6-fold less impact than varying input DNA amount, and (iii) when restricted to a limited DNA concentration (<1μg), changing the amount of amplification produces little variation. These trends were also observed when examining the metagenomes for gene function and assembly performance, although the latter more closely aligned to sequencing effort and read length than preparation steps tested. Among Illumina library preparation options, transposon-based libraries diverged from all others and adaptor ligation was a critical step for optimizing sequencing yields. Conclusions These data guide researchers in generating systematic, comparative datasets to understand complex ecosystems, and suggest that neither varied amplification nor sequencing platforms will deter such efforts.
RICHARD H. GROVE / VINITA DAMODARAN / SATPAL SANGWAN (eds.): Nature and the Orient. The Environmental History of South and Southeast Asia
Creators: name: Frasch, Tilman
Publisher: name: Internationales Asienforum
Year: 2017

description: Internationales Asienforum, Bd. 30 Nr. 3-4 (1999): Internationales Asienforum
Is there a relationship between Aaker's Brand Equity Management model and repurchasing of commercial grade exercise equipment in the Australian fitness industry?
Creators: name: Noone, Andrew
Publisher: name: Swinburne
Year: 2024

description: Brand equity is an important strategy-based concept that serves to improve marketing productivity. Brand equity has a number of important implications related to competitive advantage and profits but a number of gaps remain in the literature. Brand equity struggles to achieve credibility in the absence of a consistent definition and measurements. Current research into brand equity remains conceptual with the need to establish strong relationships between brand equity and profits. This thesis modifies Aaker’s model of brand equity management (BEM) to include three inner constructs of brand awareness (BA); brand quality (BQ); brand loyalty (BL). There are nine outer constructs that are related to the three inner constructs that include: BA= Product knowledge & brand knowledge: BQ= product quality + warranty and service: BL= personal service + pricing + value adds + finance + trust. This model is used to investigate the relationship between brand equity and a customer’s decision to repurchase. Measuring the relationship between repurchasing and the three inner and nine outer constructs of brand equity has both theoretical and practical implications. A 'repeat customer' bases their decision on a number of considerations which include the quality of the product (product quality); their knowledge of the brand and the product (brand awareness) and their relationship and trust in the supplier (brand loyalty). To test the relationship between brand equity and the decision to repurchase, data was collected from 177 owners and managers of Australian fitness clubs. To qualify, respondents were required to be involved in the decision making process for the selection of exercise equipment for their facility. Each of the twelve constructs of the brand equity model were tested independently and then together in a structured equation modelling technique using partial least square analysis. The findings supported the model and found strong relationships between all constructs, both independently and collectively. These findings have strong implications for marketing managers seeking to establish an operational plan to increase customer retention and repurchases. The limitations of the thesis and future research directions are also discussed.
Novel genomic resources for a climate change sensitive mammal: characterization of the American pika transcriptome
Creators: name: Lemay, Matthew A.
name: Henry, Philippe
name: Lamb, Clayton T.
name: Robson, Kelsey M.
name: Russello, Michael A.
Publisher: name: BioMed Central
Year: 2016

description: Background: When faced with climate change, species must either shift their home range or adapt in situ in order to maintain optimal physiological balance with their environment. The American pika (Ochotona princeps) is a small alpine mammal with limited dispersal capacity and low tolerance for thermal stress. As a result, pikas have become an important system for examining biotic responses to changing climatic conditions. Previous research using amplified fragment length polymorphisms (AFLPs) has revealed evidence for environmental-mediated selection in O. princeps populations distributed along elevation gradients, yet the anonymity of AFLP loci and lack of available genomic resources precluded the identification of associated gene regions. Here, we harnessed next-generation sequencing technology in order to characterize the American pika transcriptome and identify a large suite of single nucleotide polymorphisms (SNPs), which can be used to elucidate elevation- and site-specific patterns of sequence variation. Results: We constructed pooled cDNA libraries of O. princeps from high (1400m) and low (300m) elevation sites along a previously established transect in British Columbia. Transcriptome sequencing using the Roche 454 GS FLX titanium platform generated 780 million base pairs of data, which were assembled into 7,325 high coverage contigs. These contigs were used to identify 24,261 novel SNP loci. Using high resolution melt analysis, we developed 17 of these SNPs into genotyping assays, which were validated with independent DNA samples from British Columbia Canada and Oregon State USA. In addition, we detected haplotypes in the NADH dehydrogenase subunit 5 of the mitochondrial genome that were fixed and different among elevations, suggesting that this may be an informative target gene for studying the role of cellular respiration in local adaptation. We also identified contigs that were unique to each elevation, including a high elevation-specific contig that was a positive match with the hemoglobin alpha chain from the plateau pika, a species restricted to high elevation steppes in Asia. Elevation-specific contigs may represent candidate regions subject to differential levels of gene expression along this elevation gradient. Conclusions: To our knowledge, this is the first broad-scale, transcriptome-level study conducted within the Ochotonidae, providing novel genomic resources for studying pika ecology, behaviour and population history.
R.F. YOUNG / G.P.V. SOMARATNA: Vain Debates. The Buddhist-Christian Controversies of Nineteenth-century Ceylon; R.F. YOUNG, S. JEBANESAN: The Bible Trembled. The Hindu-Christian Controversies of Nineteenth-century Ceylon
Creators: name: Degener, Almuth
Publisher: name: Internationales Asienforum
Year: 2017

description: Internationales Asienforum, Bd. 30 Nr. 3-4 (1999): Internationales Asienforum
KLAUS-JOSEF NOTZ (ed.): Das Lexikon des Buddhismus. Grundbegriffe, Traditionen, Praxis
Creators: name: Von Hinüber, Oskar
Publisher: name: Internationales Asienforum
Year: 2017

description: Internationales Asienforum, Bd. 30 Nr. 3-4 (1999): Internationales Asienforum
Simulation of Temperature Distribution in Biochar Kiln with Different Feedstock Types
Creators: name: Tipapon Khamdaeng
Publisher: name: Faculty of Engineering, Mahasasakham University
Year: 2019
Subjects: Biochar
Feedstock
Pyrolysis
Simulation
Thermalcharacteristics

description: Mahasarakham International Journal of Engineering Technology, 5, 2, 59-64
HILTRUD HERBERS: Arbeit und Ernährung in Yasin. Aspekte des Produktions-Reproduktions-Zusammenhangs in einem Hochgebirgstal Nordpakistans
Creators: name: Müller-Böker, Ulrike
Publisher: name: Internationales Asienforum
Year: 2017

description: Internationales Asienforum, Bd. 30 Nr. 3-4 (1999): Internationales Asienforum
ANNA SCHMID: Die Dom zwischen sozialer Ohnmacht und kultureller Macht. Interethnische Beziehungen in Nordpakistan
Creators: name: Frembgen, Jürgen W.
Publisher: name: Internationales Asienforum
Year: 2017

description: Internationales Asienforum, Bd. 30 Nr. 3-4 (1999): Internationales Asienforum
JÖRG ZIMMERMANN: Kleinproduktion in Pakistan. Die exportorientierte Sportartikelindustrie in Sialkot/Pakistan
Creators: name: Zingel, Wolfgang-Peter
Publisher: name: Internationales Asienforum
Year: 2017

description: Internationales Asienforum, Bd. 30 Nr. 3-4 (1999): Internationales Asienforum
JOSIANE CAUQUELIN / PAUL LIM / BIRGIT MAYER-KÖNIG (eds.): Asian Values: Encounter with Diversity
Creators: name: Messner, Angelika
Publisher: name: Internationales Asienforum
Year: 2017

description: Internationales Asienforum, Bd. 30 Nr. 3-4 (1999): Internationales Asienforum
Support, Bedarfserhebung, Wissensvermittlung: Der DARIAH-DE Helpdesk
Creators: name: Bertino, Andrea
name: Rohden, Jan
Publisher: name: Humboldt-Universität zu Berlin
Year: 2019
Subjects: subject: library
subject: Open Access
subject: sustainability
subject: support
subject: organisational structure
subject: research infrastructure
subject: Bibliothek
subject: Nachhaltigkeit
subject: Organisationsstruktur
subject: Forschungsinfrastruktur
subject: 020 Bibliotheks- und Informationswissenschaften

description: The sustainability of a digital research infrastructure relies not only on technology, but first and foremost on the trust of its users. In turn, this trust results in particular from the tangible added value that the services provided by the research infrastructure offer its users. In order to be able to offer this added value on an ongoing basis, the services of a virtual research infrastructure must not only be continuously developed, but it is also necessary that the users are supported in all questions regarding the use of the services. This article outlines a model for integrating continuous development and user-friendly infrastructure support services. The basis for this outline is a reassessment of the helpdesk of DARIAH-DE, Germany’s participation in the European research infrastructure DARIAH-EU (Digital Research Infrastructure for the Arts and Humanities).
description: Die Nachhaltigkeit einer digitalen Forschungsinfrastruktur hängt nicht nur von Technik, sondern vor allem von dem Vertrauen ihrer NutzerInnen ab. Dieses Vertrauen wiederum resultiert insbesondere aus dem erkennbaren Mehrwert, den die Angebote der Forschungsinfrastruktur den NutzerInnen bieten können. Um diesen Mehrwert dauerhaft bieten zu können, müssen die Dienste einer Virtuellen Infrastruktur nicht nur kontinuierlich weiterentwickelt werden, sondern es ist auch notwendig, dass die NutzerInnen bei allen mit der Verwendung der Angebote verbundenen Fragen unterstützt werden. Der vorliegende Beitrag skizziert ein Modell, um fortlaufende Weiterentwicklung und nutzerfreundliche Unterstützungsangebote der Infrastruktur zu vereinen. Die Grundlage dafür bildet eine Neubetrachtung des Helpdesks von DARIAH-DE, der deutschen Beteiligung an der europäischen Forschungsinfrastruktur DARIAH-EU (Digital Research Infrastructure for the Arts and Humanities).
Transcriptome resources and functional characterization of monoterpene synthases for two host species of the mountain pine beetle, lodgepole pine (Pinus contorta) and jack pine (Pinus banksiana)
Creators: name: Hall, Dawn E.
name: Yuen, Macaire M. S.
name: Jancsik, Sharon
name: Quesada, Alfonso L.
name: Dullat, Harpreet K.
name: Li, Maria
name: Henderson, Hannah
name: Arango-Velez, Adriana
name: Liao, Nancy Y.
name: Docking, Roderick T.
name: Chan, Simon K.
name: Cooke, Janice E.
name: Breuil, Colette
name: Jones, Steven J. M.
name: Keeling, Christopher I.
name: Bohlmann, Jörg
Publisher: name: BioMed Central
Year: 2016

description: Background: The mountain pine beetle (MPB, Dendroctonus ponderosae) epidemic has affected lodgepole pine (Pinus contorta) across an area of more than 18 million hectares of pine forests in western Canada, and is a threat to the boreal jack pine (Pinus banksiana) forest. Defence of pines against MPB and associated fungal pathogens, as well as other pests, involves oleoresin monoterpenes, which are biosynthesized by families of terpene synthases (TPSs). Volatile monoterpenes also serve as host recognition cues for MPB and as precursors for MPB pheromones. The genes responsible for terpene biosynthesis in jack pine and lodgepole pine were previously unknown. Results: We report the generation and quality assessment of assembled transcriptome resources for lodgepole pine and jack pine using Sanger, Roche 454, and Illumina sequencing technologies. Assemblies revealed transcripts for approximately 20,000 - 30,000 genes from each species and assembly analyses led to the identification of candidate full-length prenyl transferase, TPS, and P450 genes of oleoresin biosynthesis. We cloned and functionally characterized, via expression of recombinant proteins in E. coli, nine different jack pine and eight different lodgepole pine mono-TPSs. The newly identified lodgepole pine and jack pine mono-TPSs include (+)-α-pinene synthases, (-)-α-pinene synthases, (-)-β-pinene synthases, (+)-3-carene synthases, and (-)-β-phellandrene synthases from each of the two species. Conclusion: In the absence of genome sequences, transcriptome assemblies are important for defence gene discovery in lodgepole pine and jack pine, as demonstrated here for the terpenoid pathway genes. The product profiles of the functionally annotated mono-TPSs described here can account for the major monoterpene metabolites identified in lodgepole pine and jack pine.