cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
(500348) William Hutchens
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
ПРАВОВОЙ РЕЖИМ НАЦИОНАЛЬНОГО ДОСТОЯНИЯ
Creators: name: Лейла Артуровна Кинетова
name: Александр Иванович Коновалов
Publisher: name: Закон и право
Year: 2020
Subjects: национальное достояние
недра
природные ресурсы
государственная собственность
правовой режим

description: Россия — богатейшая страна с огромным природно-ресурсным потенциалом. Общество должно быть владельцем земельных, водных и прочих природных ресурсов, обусловливающих жизнедеятельность всех его членов. Правовой режим национального достояния формирует сопричастность граждан к единому территориальному, экономическому, культурно-историческому и духовно-ценностному пространству в государственно-политическом аспекте.
An elementary approach to asymptotic behavior in the Cesàro sense and applications to the Laplace and Stieltjes transforms
Creators: name: Nemzer, Dennis
name: Vindas, Jasson
Publisher: name: arXiv
Year: 2015
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: Primary 41A60, 44A40. Secondary 44A10, 44A15, 46F10, 46F12

description: We present a elementary approach to asymptotic behavior of generalized functions in the Cesàro sense. Our approach is based on Yosida's subspace of Mikusiński operators. Applications to Laplace and Stieltjes transforms are given.
description: 12 pages
ОТНОШЕНИЯ ЧЕЛОВЕКА И ГОСУДАРСТВА В МЕНЯЮЩЕМСЯ ПОСТВОЕННОМ МИРЕ ЧЕРЕЗ ПРИЗМУ ВЕЧНЫХ ЦЕННОСТЕЙ И ПРАВОВОЙ КУЛЬТУРЫ
Creators: name: Елена Викторовна Былинкина
name: Светлана Эдуардовна Ливанова
Publisher: name: Закон и право
Year: 2020
Subjects: фундаментальные ценности
правовая культура
информационное общество
информационные технологии

description: Поствоенный мир охарактеризовался бурным развитием информационных технологий, что в результате привело к становлению информационного общества. Представляется, что осью развития поствоенного информационного общества должны стать фундаментальные подлинные вечные духовные ценности общества, которые укореняются в нем через знания (информацию в широком смысле) и способствуют повышению правовой культуры, а также соблюдению основанных на этих ценностях норм поведения. В статье исследованы понятие и процесс универсализации фундаментальных духовных ценностей, влияние информационных технологий на формирование правовой культуры, взаимоотношения человека и государства.
NF-κB and IκBα are found in the mitochondria. Evidence for regulation of mitochondrial gene expression by NF-κB
Creators: name: Reuther, J.Y.
name: Bristow, C.
name: Kashatus, D.F.
name: Guttridge, D.C.
name: Baldwin Jr., A.S.
name: Cogswell, P.C.
name: Keifer, J.A.
name: Roy, S.
name: Nicholson, D.W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: The transcription factor NF-κB has been shown to be predominantly cytoplasmically localized in the absence of an inductive signal. Stimulation of cells with inflammatory cytokines such as tumor necrosis factor α or interleukin-1 induces the degradation of IκB, the inhibitor of NF-κB, allowing nuclear accumulation of NF-κB and regulation of specific gene expression. The degradation of IκB is controlled initially by phosphorylation induced by the IκB kinase, which leads to ubiquitination and subsequent proteolysis of the inhibitor by the proteasome. We report here that NF-κB and IκBα (but not IκBβ) are also localized in the mitochondria. Stimulation of cells with tumor necrosis factor α leads to the phosphorylation of mitochondrial IκBα and its subsequent degradation by a nonproteasome-dependent pathway. Interestingly, expression of the mitochondrially encoded cytochrome c oxidase III and cytochrome b mRNAs were reduced by cytokine treatment of cells. Inhibition of activation of mitochondrial NF-κB by expression of the superrepressor form of IκBα inhibited the loss of expression of both cytochrome c oxidase III and cytochrome b mRNA. These data indicate that the NF-κB regulatory pathway exists in mitochondria and that NF-κB can negatively regulate mitochondrial mRNA expression.
Effect of the double-counting functional on the electronic and magnetic properties of half-metallic magnets using the GGA+U method
Creators: name: Tsirogiannis, Christos
name: Galanakis, Iosif
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Methods based on the combination of the usual density functional theory (DFT) codes with the Hubbard models are widely used to investigate the properties of strongly correlated materials. Using first-principle calculations we study the electronic and magnetic properties of 20 half-metallic magnets performing self-consistent GGA+U calculations using both the atomic-limit (AL) and around-mean-field (AMF) functionals for the double counting term, used to subtract the correlation part from the DFT total energy, and compare these results to the usual generalized-gradient-approximation (GGA) calculations. Overall the use of AMF produces results similar to the GGA calculations. On the other hand the effect of AL is diversified depending on the studied material. In general the AL functional produces a stronger tendency towards magnetism leading in some cases to unphysical electronic and magnetic properties. Thus the choice of the adequate double-counting functional is crucial for the results obtained using the GGA+U method.
(500343) Ann Skipp
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
О НЕКОТОРЫХ АСПЕКТАХ ДИСТАНЦИОННОЙ РАБОТЫ
Creators: name: Юлия Александровна Новикова
Publisher: name: Закон и право
Year: 2020
Subjects: дистанционная работа
рабочее место
прогул
изменение трудового договора
расторжение трудового договора по инициативе работодателя

description: Статья посвящена анализу норм Трудового кодекса РФ о дистанционной работе как проявлению дифференциации в трудовом праве. Некоторые категории трудового права, такие, как «рабочее время», «прогул», «обязанности работодателя» исследуются применительно к дистанционной работе. Предлагаются различные варианты оформления перехода сторон трудового договора к дистанционной работе.
ПРАВОВОЕ РЕГУЛИРОВАНИЕ СТАТУСА НАУЧНЫХ КОЛЛЕКТИВОВ КАК УЧАСТНИКОВ ГРАНТОВОЙ ДЕЯТЕЛЬНОСТИ В РОССИЙСКОЙ ФЕДЕРАЦИИ. Состояние, проблемы
Creators: name: Майя Владленовна Пучкова
Publisher: name: Закон и право
Year: 2020
Subjects: статус научных коллективов как грантополучателей
научная деятельность
государственные гранты на научные исследования
правовое регулирование
законодательство Российской Федерации
грантовые правоотношения

description: Статья посвящена малоизученной теме — правовому статусу научных коллективов как участников грантовой деятельности. Дано рабочее определение научного коллектива как субъекта этой деятельности. Анализируются вопросы регламентации в законодательстве прав, обязанностей, ответственности и других элементов их статуса. Выявлены его особенности. Сформулированы предложения по совершенствованию законодательства в части регулирования указанных вопросов.
Solid waste management in tourism destinations in Tunisia
Creators: name: Chaabane, Wassim
Publisher: name: Universität Rostock
Year: 2019
Subjects: subject: 330 Economics
subject: 910 Geography & travel

description: Tourism sector represents an important economic activity in Tunisia. The cleanliness of the tourism destinations is an important parameters to ensure the development of the sector. In this work, a key set of indicators were developed for solid waste management in tourism in Tunisia. Based on this, the situation was diagnosted, and sustainable organisational, financial and technical solutions were developed to ensure clean, circular and sustainable tourism throughout the year.
The transcription factor NF-κB and human disease
Creators: name: Baldwin, A.S.
Publisher: name: The American Society for Clinical Investigation
Year: 2001

description: Beginning with its discovery in 1986 and continuing through the present, the transcription factor NF-kB has attracted widespread interest based on its unusual regulation, the variety of stimuli that activate it, the diverse genes and biological responses that it controls, the striking evolutionary conservation of structure and function among family members, and its apparent involvement in a variety of human diseases (Table 1). Importantly, and consistent with the last point, NF-kB has been shown to be the target of several anti-inflammatory and anticancer drugs.
Deep Boosting: Layered Feature Mining for General Image Classification
Creators: name: Peng, Zhanglin
name: Lin, Liang
name: Zhang, Ruimao
name: Xu, Jing
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences
subject: 68U01

description: Constructing effective representations is a critical but challenging problem in multimedia understanding. The traditional handcraft features often rely on domain knowledge, limiting the performances of exiting methods. This paper discusses a novel computational architecture for general image feature mining, which assembles the primitive filters (i.e. Gabor wavelets) into compositional features in a layer-wise manner. In each layer, we produce a number of base classifiers (i.e. regression stumps) associated with the generated features, and discover informative compositions by using the boosting algorithm. The output compositional features of each layer are treated as the base components to build up the next layer. Our framework is able to generate expressive image representations while inducing very discriminate functions for image classification. The experiments are conducted on several public datasets, and we demonstrate superior performances over state-of-the-art approaches.
description: 6 pages, 4 figures, ICME 2014
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB
Creators: name: Baldwin, A.S.
Publisher: name: The American Society for Clinical Investigation
Year: 2001

description: The abilities of NF-κB to promote cell proliferation, suppress apoptosis, promote cell migration, and suppress differentiation apparently have been co-opted by cellular and viral oncoproteins to promote oncogenesis (Figure 2). Direct evidence, using both in vitro and in vivo models, indicates that NF-κB is required for oncogenesis, probably at multiple levels. NF-κB likely plays an important role in the early events of oncogenesis, possibly functioning primarily in protecting against transformation-associated apoptosis. In most late-stage tumor cells, classic NF-κB (the p50-p65 heterodimer) is clearly not the only survival factor, because its inhibition does not induce apoptosis in many of these tumor cells. This observation suggests that other events have occurred to upregulate NF-κB-independent cell survival pathways. However, clearly some cancer cells depend on NF-κB for their survival. NF-κB also can contribute to cell progression by transcriptionally upregulating cyclin D1 with corresponding hyperphosphorylation of the tumor suppressor protein Rb. The induction of NF-κB-controlled proliferation may correlate with loss of differentiation in certain settings (47), which may promote oncogenesis. NF-κB is known to regulate certain genes associated with metastasis, such as matrix metalloproteinase 9, tissue plasminogen activator, and ICAM-1. Thus, a more relevant role for NF-κB in later-stage oncogenesis may be to promote metastasis and angiogenesis. Although many tumor cells display some level of constitutive nuclear NF-κB, higher levels of NF-κB and the transcriptional potential of NF-κB can be further enhanced in response to certain types of chemotherapy. Consistent with this, inhibition of NF-κB in parallel with certain (but apparently not all) chemotherapy treatments strongly enhances the apoptotic potential of the chemotherapy. This observation indicates that NF-κB plays an important role in inducible chemoresistance and establishes NF-κB inhibition as a new adjuvant approach in chemotherapy.
TANA model
Creators: name: Jaeggi Till
Publisher: name: Zenodo
Year: 2022
Subjects: Agent based model, GAMA, land use change, pattern oriented modelling (POM)

description: The TANA model is an explorative and stylized agent-based model (ABM) built with GAMA (https://gama-platform.org/). Tthe model was developed within the framework of the tana project. It attempts to reproduce the observed patterns by exploring the decision-making processes of agents which represent smallholding subsistence farmer of Antananarivo. Rather than delivering empirical results, the TANA model should provide a virtual laboratory for testing the simple causal roles of demographic, economic and environmental factors which are assumed to shape the land-use system. The different land use options of the households are limited mostly to environmental constraints (also economical). This allows to visually illustrate how the change of the landscape affects the decisions of the households over time and vice versa. Further TANA model aims at showing the distribution of different land uses over time.
description: {"references": ["Taillandier, P., Gaudou, B., Grignard, A., Huynh, Q.N., Marilleau, N., Caillou, P., Philippon, D., Drogoul, A. (2018), Building, composing and experimenting complex spatial models with the GAMA platform. In Geoinformatica, Springer, https://doi.org/10.1007/s10707-018-00339-6."]}
ПОСТАНОВЛЕНИЕ № 436 СОВЕТА НАРОДНЫХ КОМИССАРОВ СОЮЗА ССР «О ПЕРЕСТРОЙКЕ РАБОТЫ ЭКОНОМСОВЕТА». (03.04.1940). К вопросу о правоприменении
Creators: name: Любовь Николаевна Денисова
Publisher: name: Закон и право
Year: 2020
Subjects: нефтяная промышленность
Совет по топливу и электрохозяйству при Совете Народных Комиссаров СССР
Государственная Плановая Комиссия при Совете Народных Комиссаров СССР
Бюро Совета Народных Комиссаров СССР

description: Автор анализирует развитие нефтяной промышленности СССР в предвоенные 1940 — 1941 годы на основании реализации постановления СНК СССР «О перестройке работы Экономсовета». Особое внимание уделено развитию добычи и переработки нефти в Азербайджане, Грозном и Поволжье — главных топливных районах страны.
Data Governance im Spannungsfeld datengetriebener Verwaltung. Herausforderungen von Kommunen bei der Etablierung einer Smart City Administration
Creators: name: De Macedo Schäfer,
name: Schweinberg
name: Stenzel
name: Von Grafenstein,
Publisher: name: Zenodo
Year: 2023
Subjects: Data Governance
Smart City
Datengetriebene Verwaltung
proprietäre Daten
Open Data
Data Commons
Intermediäre
Public-Private-Partnerships

description: Die digitale Transformation bedingt eine Aktualisierung bestehender Definitionen und Verständnisse von gemeinwohlorientierter Daseinsvorsorge. Die erfolgreiche Einführung und Verwaltung innovativer digitaler, datengetriebener Dienste werden derzeit durch erhebliche Unsicherheiten darüber behindert, wer auf welche Daten von welchem Akteur unter welchen Bedingungen zugreifen und diese verwenden darf. Hierbei findet sich die Verwaltung üblicherweise in drei grundsätzlich unterschiedlichen Datenteilungsszenarien bzw. -modellen wieder: Proprietäre Modelle, Open Data-Modelle sowie zunehmend Data Commons-Modelle, die meist auf die Koordinierungsfunktion spezialisierter Datenintermediäre setzen. Das vorliegende Discussion Paper beschreibt das jeweilige Modell mit einer summarischen Darstellung der jeweiligen Vor- und Nachteile – und wie sich eine datengetriebene Verwaltung optimalerweise die Vorteile nutzbar machen kann, um eine gemeinwohlorientierte Organisation einer Smart City zu realisieren.
Positive and negative regulation of NF-κB by COX-2. Roles of different prostaglandins
Creators: name: Poligone, B.
name: Baldwin, A.S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: The prostaglandin H synthases (PGHS) catalyze the conversion of arachidonic acid to prostaglandin H2, the committed step in prostanoid synthesis. Two forms of PGHS exist, PGHS-1 (COX-1) and PGHS-2 (COX-2). The gene encoding the latter form is known to be inducible by a number of stimuli including several inflammatory mediators. Recent evidence indicates that the inducible cyclooxygenase may have both pro- and anti-inflammatory properties through the generation of different prostaglandins. Previous reports indicate that the transcription factor NF-κB can function upstream of COX-2 to control transcription of this gene and that the cyclopentenone prostaglandins can inhibit NF-κB activation via the inhibition of the IκB kinase. Thus, it is suggested that cyclopentenones feed back to inhibit continued nuclear accumulation of NF-κB. In this report we demonstrate COX-2 expression inhibits nuclear translocation of NF-κB, and we confirm that the cyclopentenone prostaglandins inhibit NF-κB. In addition, we show that prostaglandin E2 and its analogs promote the inherent transcriptional activity of the p65/RelA subunit of NF-κB in a manner independent of induced nuclear accumulation. Consistent with this evidence, prostaglandin E2 strongly synergizes with the inflammatory cytokine tumor necrosis factor-α to promote NF-κB-dependent transcription and gene expression. The data provide a molecular rationale to explain both the pro-and anti-inflammatory nature of COX-2.
ФЕДОР ВАСИЛЬЕВИЧ ТАРАНОВСКИИ О ПРОБЛЕМЕ СООТНОШЕНИЯ ПРАВА И HРАВСТВЕHHОСТИ
Creators: name: Дина Викторовна Алонцева
Publisher: name: Закон и право
Year: 2020
Subjects: право
нравственность
общество
государственность

description: Статья посвящена проблеме соотношения права и нравственности в концепции выдающего ученого, академика, профессора и историка права Федора Васильевича Тарановского. Сделан акцент на роль права и нравственности в общественном развитии.
Inhibition of NF-κB Activity by Thalidomide through Suppression of IκB Kinase Activity
Creators: name: Baldwin Jr., A.S.
name: Ashburner, B.P.
name: Guttridge, D.C.
name: Keifer, J.A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: The sedative and anti-nausea drug thalidomide, which causes birth defects in humans, has been shown to have both anti-inflammatory and anti-oncogenic properties. The anti-inflammatory effect of thalidomide is associated with suppression of cytokine expression and the anti-oncogenic effect with inhibition of angiogenesis. It is presently unclear whether the teratogenic properties of thalidomide are connected in any way to the beneficial, anti-disease characteristics of this drug. The transcription factor NF-κB has been shown to be a key regulator of inflammatory genes such as tumor necrosis factor-α and interleukin-8. Inhibition of NF-κB is associated with reduced inflammation in animal models, such as those for rheumatoid arthritis. We show here that thalidomide can block NF-κB activation through a mechanism that involves the inhibition of activity of the IκB kinase. Consistent with the observed inhibition of NF-κB, thalidomide blocked the cytokine-induced expression of NF-κB-regulated genes such as those encoding interleukin-8, TRAF1, and c-IAP2. These data indicate that the therapeutic potential for thalidomide may be based on its ability to block NF-κB activation through suppression of IκB kinase activity.
Visualization of Precision Medicine: A Case Study of PD-1 Therapy Efficacy Evaluation through  Analytical Algorithm in Triple Negative Breast Cancer
Creators: name: Jiang, Alice
Publisher: name: Zenodo
Year: 2023

description: Triple Negative Breast Cancer (TNBC) is an aggressive breast cancer subtype that lacks estrogen
receptor, progesterone receptor, and human epidermal growth factor receptor 2, accompanied by
a heightened recurrence risk. While chemotherapy remains the prevailing standard of care, high
molecular heterogeneity and a strong tendency to develop chemotherapy resistance pose
treatment challenges. Precision medicine emerges as a promising paradigm shift, maximizing the
therapeutic effect by individualizing treatment to account for characteristic differences. In this
study, we explored PD-1 therapies as a novel approach to TNBC treatments with better efficacy
than chemotherapy. The interaction between PD-L1 expressed on cancerous cells and PD-1
assists in escaping anti-tumor immune responses. Thus, it employs monoclonal antibodies to
target the PD-1 receptor, blocking the ligands that inhibit the cell's cytokine secretion and induce
apoptosis. The aim of our work is to implement the concept of precision medicine to investigate
the drug efficacy of PD-1 therapy based on individual TNBC profiles. An analytical algorithm
that evaluates the correlation between influential factors and the effectiveness extent of PD-1
therapy is developed using Python. After refining possible input/output factors, we generated
mock data from a clinical data resource and simulated via our analytical algorithm to conclude
similar results as the literature. Our research demonstrates the feasibility of the analytical
platform by applying precision medicine through a case study of PD-1 treatment for TNBC.
Future work will focus on extending the framework to precision medicine for other diseases,
unlocking insights to optimize medical therapeutic strategies across diverse individuals.
title: The planners' poem
title: Le poème des urbanistes
titleType: AlternativeTitle
Creators: name: Steil, John
Publisher: name: Canadian Institute of Planners
Year: 2017
Subjects: subject: Planners--Poetry
subject: Urbanistes--Poésie

description: After pulling some planning texts and journals from nearby shelves, I was on the hunt for phrases to create a planners’ poem.
description: Après avoir sélectionné plusieurs textes et revues traitant d’urbanisme sur les étagères qui m’entouraient, je me lançai à la recherche de vers pour composer un poème sur les urbanistes.
(500344) John Rumsey
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
ИНКЛЮЗИВНОЕ ОБРАЗОВАНИЕ КАК УСЛОВИЕ ОБЕСПЕЧЕНИЯ ПОЛНОЦЕННОГО И БЕЗОПАСНОГО РАЗВИТИЯ ДЕТЕЙ С ОГРАНИЧЕННЫМИ ВОЗМОЖНОСТЯМИ ЗДОРОВЬЯ
Creators: name: Оксана Владимировна Нардина
Publisher: name: Закон и право
Year: 2020
Subjects: инклюзивное образование
несовершеннолетние с ограниченными возможностями здоровья
недопустимость дискриминации в сфере образования
безопасность развития

description: Для российской образовательной системы инклюзивное образование является сравнительно новой формой, поэтому на пути его становления все участники образовательного процесса сталкиваются с серьезными проблемами. Автор считает необходимым развивать и повсеместно внедрять инклюзивное образование, поскольку оно не только содействует реализации и защите комплекса социально-культурных конституционных прав на образование детей с ограниченными возможностями здоровья, но и обеспечивает их полноценное и безопасное развитие.
Interleukin-10 signaling blocks inhibitor of κB kinase activity and nuclear factor κB DNA binding
Creators: name: Balfour Sartor, R.
name: Mayo, M.W.
name: Baldwin Jr., A.S.
name: Schottelius, A.J.G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: The transcription factor nuclear factor κB (NF-κB) coordinates the activation of numerous genes in response to pathogens and proinflammatory cytokines and is, therefore, pivotal in the development of acute and chronic inflammatory diseases. In its inactive state, NF-κB is constitutively present in the cytoplasm as a p50-p65 heterodimer bound to its inhibitory protein IκB. Proinflammatory cytokines, such as tumor necrosis factor (TNF), activate NF-κB by stimulating the activity of the IκB kinases (IKKs) which phosphorylate IκBα on serine residues 32 and 36, targeting it for rapid degradation by the 26 S proteasome. This enables the release and nuclear translocation of the NF-κB complex and activation of gene transcription. Interleukin-10 (IL-10) is a pleiotropic cytokine that controls inflammatory processes by suppressing the production of proinflammatory cytokines which are known to be transcriptionally controlled by NF-κB. Conflicting data exists on the effects of IL-10 on TNF- and LPS-induced NF-≃B activity in human monocytes and the molecular mechanisms involved have not been elucidated. In this study, we show that IL-10 functions to block NF-≃B activity at two levels: 1) through the suppression of IKK activity and 2) through the inhibition of NF-κB DNA binding activity. This is the first evidence of an anti-inflammatory protein inhibiting IKK activity and demonstrates that IKK is a logical target for blocking inflammatory diseases.
ФЕДЕРАЛЬНЫЕ ЗАКОНЫ КАК ЭЛЕМЕНТ ИЕРАРХИЧЕСКОЙ СИСТЕМЫ НАЦИОНАЛЬНОГО ЗАКОНОДАТЕЛЬСТВА В СФЕРЕ ВНЕШНЕЙ ТРУДОВОЙ МИГРАЦИИ
Creators: name: Павел Олегович Дутов
Publisher: name: Закон и право
Year: 2020
Subjects: внешняя трудовая миграция
трудовая деятельность
трудовой мигрант
иерархическая система
национальное законодательство
миграционное законодательство
федеральные законы

description: В статье проведен анализ федеральных законов, входящих в иерархическую систему национального законодательства в сфере внешней трудовой миграции. Подробному изучению подверглись не только федеральные законы, напрямую затрагивающие сферу миграции, но и иные федеральные законы, в том числе кодифицированные акты российского законодательства.
МЕТОДОЛОГИЧЕСКИЕ ПОДХОДЫ К ИЗУЧЕНИЮ СИСТЕМАТИЗАЦИИ СОВРЕМЕННОГО ЗАКОНОДАТЕЛЬСТВА
Creators: name: Георгий Александрович Шитов
Publisher: name: Закон и право
Year: 2020
Subjects: метод
систематизация законодательства
всеобщая методология
методология права
диалектический метод
формально-логический метод
формально-юридический метод
догматический метод.

description: В статье исследуется возможность применения различных методологических подходов к изучению систематизации законодательства как многоуровневого и сложного правового явления.
(500345) Mary Ann Goffe
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
О ПРАВОВОМ РЕГУЛИРОВАНИИ ЦИФРОВИЗАЦИИ В российской федерации
Creators: name: Георгий Мангулиевич Бутбая
name: Нодари Дарчоевич Эриашвили
Publisher: name: Закон и право
Year: 2020
Subjects: Федеральный закон Российской Федерации «Об информации
информационных технологиях и о защите информации» от 8 июля 2006 г.
право
отрасль права
цифровое право
цифровизация.

description: В статье на основе анализа литературы и законодательства относительно регулирования цифровизации в Российской Федерации авторы высказали следующие соображения: предназначение цифровизации в аспекте поиска оптимального сочетания между экономикой и правом ныне в Российской Федерации отсутствует; правовой основной цифровизации являются положения Конституции РФ; нормативным правовым актом, специально предназначенным для регулирования цифровизации, необходимо рассматривать Федеральный закон Российской Федерации «Об информации, информационных технологиях и о защите информации» от 8 июля 2006 г.
Apoptosis promotes a caspase-induced amino-terminal truncation of IκBα that functions as a stable inhibitor of NF-kB
Creators: name: Reuther, J.Y.
name: Baldwin Jr., A.S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: Caspases are cell death cysteine proteases that are activated upon the induction of the apoptotic program and cleave target proteins in a sequence- specific manner to promote cell death. Recently, Barkett et al. (Barkett, M., Xue, D., Horvitz, H. R., and Gilmore, T. D. (1997) J. BioL Chem. 272, 29419- 29422) have shown that IκBα, the inhibitory subunit of the transcription factor NF-κB, can be cleaved by caspase-3 in vitro at a site that potentially produces a dominant inhibitory form of IκBα. The involvement of NF-κB in the inhibition of cell death led us to ask whether apoptotic stimuli would induce the caspase-mediated cleavage of IκBα in vivo. In this study, we show that apoptosis leads to the caspase-mediated amino-terminal truncation of IκBα (δN-IκBα). Our data show that δN-IκBα can bind NF- κB, suppress NF-κB activation, and sensitize cells to death. Since activated NF-κB plays a role in the inhibition of cell death, these data suggest that caspase-mediated cleavage of IκBα may be a mechanism to suppress NF-κB and its associated antiapoptotic activity.
Involvement of double-stranded RNA-activated protein kinase in the synergistic activation of nuclear factor-κB by tumor necrosis factor-α and γ-interferon in preneuronal cells
Creators: name: Williams, B.R.G.
name: Baldwin Jr., A.S.
name: Cheshire, J.L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: Tumor necrosis factor-α (TNF-α) and γ-interferon (IFN-γ) cooperate during a variety of biological responses and ultimately synergistically enhance the expression of genes involved in immune and inflammatory responses. Recently, we demonstrated that IFN-γ can significantly potentiate TNF-α-induced nuclear factor (NF)-κB nuclear translocation in neuronal derived and endothelial cell lines. The mechanism by which these two cytokines exert their synergistic effect on NF-κB involves the de novo degradation of the NF-κB inhibitor, IκBβ. The double-stranded RNA- dependent kinase PKR is IFN-inducible and has been implicated in the activation of NF-κB; therefore, we examined the possibility that PKR may play a role in the synergistic activation of NF-κB during TNF-α/IFN-γ cotreatment. The PKR inhibitor 2-aminopurine (2-AP) inhibited TNF-α/IFN-γ- induced NF-κB nuclear translocation in neuronal derived cells but not in endothelial cells. The induced degradation of IκBβ, which is normally observed upon TNF-α/IFN-γ cotreatment, was blocked completely by 2-AP in neuronal derived cells. Also, 2-AP treatment or overexpression of a catalytically inactive PKR inhibited the TNF-α/IFN-γ-induced synergistic activation of κB-dependent gene expression. Our results suggest that the signal generated by IFN-γ, during TNF-α/IFN-γ cotreatment may require PKR to elicit enhanced NF-κB activity, and this signal may affect the stability of the IκBβ protein.
О БЕЗУСЛОВНЫХ ОСНОВАНИЯХ ОТМЕНЫ СУДЕБНЫХ АКТОВ В КАССАЦИОННОМ ПРОИЗВОДСТВЕ
Creators: name: Диана Магомедсолтановна Атаева
name: Наида Шамильевна Гаджиалиева
Publisher: name: Закон и право
Year: 2020
Subjects: гражданский процесс
кассационное производство
отмена судебных постановлений
безусловные основания
судебная ошибка

description: В статье анализируются положения Гражданского процессуального кодекса РФ, регламентирующие безусловные основания отмены судебных постановлений в кассационном порядке. Актуальность темы исследования обусловлена тем, что институт безусловных оснований отмены судебных актов слабо разработан в доктрине цивилистического процесса, хотя имеет очень важное практическое значение для защиты прав и свобод человека и гражданина. В связи с этим в целях повышения знаний о безусловных основаниях отмены судебных актов по гражданским делам в кассационной инстанции авторы раскрывают понятие и виды безусловных оснований отмены судебных актов в кассационном порядке в аспекте научной и законодательной разработки исследуемого вопроса.
(500346) William G. Mason
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
СОВРЕМЕННОЕ СОСТОЯНИЕ ЗАЩИТЫ ПРАВ ДЕТЕЙ В СЕТЕВОМ ПРОСТРАНСТВЕ ВО ВЬЕТНАМЕ
Creators: name: Доан Тхи То Уйен
Publisher: name: Закон и право
Year: 2020
Subjects: дети
защита детей
право
киберпространство
киберзащита
Вьетнам

description: Защита детей в киберпространстве всегда актуальна для каждой нации. Многие «черные» сайты поддерживают прямую трансляцию сексуального насилия над детьми, насильственного образа жизни, насилия, которые негативно влияют на поведение детей, бросают вызов правоохранительным органам. Статья посвящена анализу текущей ситуации в области защиты детей в киберпространстве во Вьетнаме.
Nuovo umanesimo e rigenerazione urbana: l'economia civile tra l'economia della Scuola francescana e l'economia circolare per la città prospera e inclusiva
Creators: name: Bosone, Martina
name: Fusco Girard, Luigi
Publisher: name: Zenodo
Year: 2019
Subjects: circular economy
cultural heritage
human-centred regeneration
beauty
intrinsic value
Historic Urban Landscape
social empowerment

description: The contribution proposes an historical excursus that identifies the common features between the economic model developed by the Franciscan school in the 1300s, the civil economy of Antonio Genovesi in the 1700s and the current model of circular economy. A very rich literature - also recent and of international scope (see the recent document of the European Commission "The Human-Centred City") (European Commission, 2019, 2020) - highlights that Humanism represents a perspective which, evoking the notion of "humanity", refers to a series of values: freedom of choice, responsibility, rationality but also care in solidarity, creativity, dignity of the person.
 There are many points in common between the model of circular economy and the notion of civil economy. The Circular Economy is the economy that recognizes the centrality of all forms of capital, from natural to human, which should not be wasted but should be properly valued.
 A form of capital as relevant as human capital is social capital, which activates forms of mutual cooperation. Moreover, the circular economy underlines the importance of use (i.e. values of use) with respect to the ownership of goods (and therefore their exchange value).
 These are elements common to the civil economy that the various authors, from Genovesi to Galliani and to Filangieri, have repeatedly stressed in their research.
 Well, these values give shape not only to the economy of the city but also to the very idea of organization of the city: they give the image of the "city of Civil Humanism", aimed at achieving the good of all, the common good.
 The city of the new humanism is first and foremost the incubator city of sinergies/symbiosis.
 Just as in nature it is verified that the systems that work best are the autopoietic ones, that is, they have the capacity for self-organization and self-management, so too the cities that best realize humanistic values are those organized in such a way as to imitate natural ecosystems. They are characterized by the paradigm of circularisation which therefore becomes the organisational paradigm of the city of the "new humanism" (Fusco Girard, 2013).
A requirement for NF-κB activation in Bcr-Abl-mediated transformation
Creators: name: Baldwin Jr., A.S.
name: Pendereast, A.M.
name: Reuther, G.W.
name: Cortez, D.
name: Reuther, J.Y.
Publisher: name: Cold Spring Harbor Laboratory Press
Year: 1998

description: Bcr-Abl is a chimeric oncoprotein that is strongly implicated in acute lymphoblastic (ALL) and chronic myelogenous leukemias (CML). This deregulated tyrosine kinase selectively causes hematopoietic disorders resembling human leukemias in animal models and transforms fibroblasts and hematopoietic cells in culture. Bcr-Abl also protects cells from death induced on cytokine deprivation or exposure to DNA damaging agents. In addition, the antiapoptotic function of Bcr-Abl is thought to play a necessary role in hematopoietic transformation and potentially in leukemogenesis. The transcription factor NF-κB has been identified recently as an inhibitor of apoptosis and as a potential regulator of cellular transformation. This study shows that expression of Bcr-Abl leads to activation of NF-κB-dependent transcription by causing nuclear translocation of NF-κB as well as by increasing the transactivation function of the Re1A/p65 subunit of NF-κB. Importantly, this activation is dependent on the tyrosine kinase activity of Bcr-Abl and partially requires Ras. The ability of Bcr-Abl to protect cytokine-dependent 32D myeloid cells from death induced by cytokine deprivation or DNA damage does not, however, require functional NF-κB. However, using a super-repressor form of IκBα, we show that NF-κB is required for Bcr-Abl-mediated tumorigenicity in nude mice and for transformation of primary bone marrow cells. This study implicates NF-κB as an important component of Bcr-Abl signaling. NF-κB-regulated genes, therefore, likely play a role in transformation by Bcr-Abl and thus in Bcr- Abl-associated human leukemias.
A survey of the high order multiplicity of nearby solar-type binary stars with Robo-AO
Creators: name: Riddle, Reed L.
name: Tokovinin, Andrei
name: Mason, Brian D.
name: Hartkopf, William I.
name: Roberts,, Lewis C.
name: Baranec, Christoph
name: Law, Nicholas M.
name: Bui, Khanh
name: Burse, Mahesh P.
name: Das, H. K.
name: Dekany, Richard G.
name: Kulkarni, Shrinivas
name: Punnadi, Sujit
name: Ramaprakash, A. N.
name: Tendulkar, Shriharsh P.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: We conducted a survey of nearby binary systems composed of main sequence stars of spectral types F and G in order to improve our understanding of the hierarchical nature of multiple star systems. Using Robo-AO, the first robotic adaptive optics instrument, we collected high angular resolution images with deep and well-defined detection limits in the SDSS $i'$ band. A total of 695 components belonging to 595 systems were observed. We prioritized observations of faint secondary components with separations over $10''$ to quantify the still poorly constrained frequency of their sub-systems. Of the 214 secondaries observed, 39 contain such subsystems; 19 of those were discovered with Robo-AO. The selection-corrected frequency of secondary sub-systems with periods from $10^{3.5}$ to $10^5$ days is 0.12$\pm$0.03, the same as the frequency of such companions to the primary. Half of the secondary pairs belong to quadruple systems where the primary is also a close pair, showing that the presence of sub-systems in both components of the outer binary is correlated. The relatively large abundance of 2+2 quadruple systems is a new finding, and will require more exploration of the formation mechanism of multiple star systems. We also targeted close binaries with periods less than 100~yr, searching for their distant tertiary components, and discovered 17 certain and 2 potential new triples. In a sub-sample of 241 close binaries, 71 have additional outer companions. The overall frequency of tertiary components is not enhanced, compared to all (non-binary) targets, but in the range of outer periods from $10^6$ to $10^{7.5}$ days (separations on the order of 500~AU), the frequency of tertiary components is 0.16$\pm$0.03, exceeding by almost a factor of two the frequency of similar systems among all targets (0.09).
ОБ УСТАНОВЛЕНИИ СОДЕРЖАНИЯ НОРМ ИНОСТРАННОГО СЕМЕЙНОГО ПРАВА
Creators: name: Анастасия Юрьевна Касаткина
Publisher: name: Закон и право
Year: 2020
Subjects: норма иностранного семейного права
установление
содержание
содействие
разъяснение

description: В статье исследуется вопрос об определении содержания норм иностранного семейного права. Исследовав законодательство, судебную практику, доктрину, автор заключил, что ныне действующие правовые механизмы определения содержания норм семейного права иностранного государства несовершенны и подлежат реформированию. Отмечены, в частности, проблемы недоступности к иностранному законодательству, регламентирующему семейные отношения, долгий и не всегда результативный поиск истинного смысла законоположений о семье, ее жизнедеятельности. Предложены конкретные меры по их пересмотру с целью повышения доступности к иностранному законодательству, качественного, оперативного и в целом эффективного его применения.
АНАЛИЗ МЕЖДУНАРОДНОГО И РОССИЙСКОГО ЗАКОНОДАТЕЛЬСТВА, РЕГЛАМЕНТИРУЮЩЕГО ПРАВОВОЕ ПОЛОЖЕНИЕ НЕСОВЕРШЕННОЛЕТНИХ ОСУЖДЕННЫХ
Creators: name: Ольга Анатольевна Лаврищева
Publisher: name: Закон и право
Year: 2020
Subjects: нормы международного и национального права
несовершеннолетние
воспитательная колония
условия отбывания наказания

description: На основании сравнительного анализа международного и национального законодательства, регламентирующего правовое положение несовершеннолетних осужденных, автор выявил основные несоответствия уголовно-исполнительного законодательства РФ международным требованиям.
Advancing Transparency Enhancing Tools for Cloud-Native Architectures and Engineering
Creators: name: Grünewald, Elias
name: Kiesel, Jannis
name: Loechel, Louis
name: Janke, Thomas
name: Akbayin, Siar-Remzi
Publisher: name: Zenodo
Year: 2023

description: Transparency, i.e. having precise information on all data categories, purpose, legal basis, and storage limitation specifications, etc., is a necessary precondition for most of the core principles relating to the processing of personal data (cf. Art. 5 GDPR). Data controllers have to take appropriate measures to provide the data subject with the mentioned transparency information accordingly (Art. 12–14 GDPR). This obligation is often fulfilled by compiling a textual privacy statement. However, many studies illustrate that data subjects are not able to understand its contents and consequences, for instance, according to involved third-party data sharing or third-country transfers. We propose new Transparency Enhancing Technologies to address these issues.
We provide the original poster and an Extended Abstract about the topic.
О ПОВЫШЕНИИ РЕГИСТРАЦИОННОЙ ПРИВЛЕКАТЕЛЬНОСТИ СУДОВЫХ РЕЕСТРОВ РОССИЙСКОЙ ФЕДЕРАЦИИ
Creators: name: Кирилл Андреевич Маслов
Publisher: name: Закон и право
Year: 2020
Subjects: регистрация судов
регистр
бербоут-чартер
снижение сроков регистрации
морской реестр
проверка документов
судовладельцы

description: В статье рассмотрены международные документы, касающиеся правил определения государством условий регистрации судов в одном из государственных реестров. Проанализировав международное законодательство, автор выделил право национального законодателя самостоятельно устанавливать сроки регистрации судов и отнесения их к определенному реестру. В настоящее время сроки регистрации в судовых реестрах Российской Федерации для всех типов судов одинаковы. Подобное отсутствие дифференциации отрицательно сказывается на расходах судовладельцев из-за невозможности эксплуатации судна во время административной процедуры. В зависимости от категории судна автором рекомендуется рассмотреть возможность установления различных сроков процедуры регистрации.
О СУБЪЕКТАХ ГРАЖДАНСКИХ ПРАВООТНОШЕНИЙ
Creators: name: Залихан Исаевна Дахаева
name: Авалу Сулейманович Абубакаров
Publisher: name: Закон и право
Year: 2020
Subjects: субъекты гражданских правоотношений
общественные отношения
нормы права
физические лица
юридические лица

description: В процессе общественной жизни люди постоянно вступают в различного рода отношения (связи): политические, трудовые, семейные, отношения обмена и др. Общественные отношения, будучи урегулированными нормами права, становятся правовыми отношениями. Правовые отношения — это общественные отношения, урегулированные правом. Данная статья направлена на изучение субъектов гражданских правоотношений.
Molecular mechanism of basic calcium phosphate crystal-induced activation of human fibroblasts: Role of nuclear factor κB, activator protein 1, and protein kinase C
Creators: name: Christopherson, P.A.
name: Augustine, J.A.
name: Baldwin, A.S.
name: Cheung, H.S.
name: Westfall, P.R.
name: McCarthy, G.M.
name: Scheinman, R.I.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Synovial fluid basic calcium phosphate (BCP) crystals are markers of severe joint degeneration in osteoarthritis. BCP crystals cause mitogenesis of articular cells and stimulate matrix metalloprotease production, thus promoting degradation of articular tissues. Previous work suggested that BCP crystal-induced cell activation required intracellular crystal dissolution, induction of proto-oncogene expression, and activation of signal transduction pathways involving protein kinase C and mitogen-activated protein kinases. Here we further elucidate the mechanisms of BCP crystal-induced cell activation as BCP crystals activate transcription factors nuclear factor κB and activator protein I in human fibroblasts. We confirm the role of protein kinase C in BCP crystal-induced mitogenesis in human fibroblasts. In contrast, we demonstrate that BCP crystals do not activate signal transduction pathways involving protein tyrosine kinases or phosphatidylinositol 3-kinase. These data further define the mechanism of cell activation by BCP crystals and confirm its selectivity, an observation that may have therapeutic implications.