cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Prevalence of Significant Weight Gain of Patients on Psychotropic Drugs Attending Psychiatric Clinic of Hospital Seri Manjung
Creators: name: BD WAHID Murniyati
name: SHAARI Nahdiya
name: MURUGAN Kalaivani
name: GOVINDAN Siva Kamini
name: MOHD APANDI Ainna Mardhiyah
name: YU Toh Yao Kelvin
name: CHIEW Shoen Chuen
Publisher: name: Zenodo
Year: 2021
Subjects: Psychotropic drugs; weight gain

description: Introduction and Objectives: Psychotropic drugs may cause weight gain. Overweight and obesity are associated with cardiovascular disease and metabolic syndrome. This study aimed to determine the prevalence of significant weight gain (at least 7% increase in weight) within 6-8 months among patients on psychotropic drugs and the contributing factors. Methods:  A retrospective record review of patients attending Psychiatric Clinic, Hospital Seri Manjung from March-November 2017 was conducted. Records of patients prescribed with psychotropic drug(s) for at least 6 months were reviewed in 2017. Data on socio-demography, co-morbidities, height, weight (6-8 months prior), current weight, diagnosis, psychotropic drugs initiation date and type were recorded using a data collection form. Results:  Data of 388 patients was analysed. Percentage of patients with significant weight gain was 12.1%. Female patients had nearly 3-fold odds of significant weight gain (OR=2.78; 95% CI: 1.39, 5.56; p=0.003) than male. Chinese patients were twice less likely of having significant weight gain (OR=0.43; 95% CI: 0.20, 0.90; p=0.025) than Malays. Patients on atypical antipsychotics had 2.5-fold odds of having significant weight gain. (OR=2.52; 95% CI: 1.27, 5.00; p=0.007). Underweight patients had 3-fold odds of having significant weight gain than patients with normal BMI (OR=3.33; 95% CI: 1.32, 8.39; p=0.011). Overweight and obese patients had lower odds of significant weight gain. Discussion/conclusion: The prevalence of patients on psychotropic drugs with significant weight gain within 6-8 months (12.1%), was in line with the standard key performance indicator (KPI) set by Ministry of Health (MOH), Malaysia of < 20%. Female gender, Malay ethnicity, atypical antipsychotics and lower baseline BMI increased the likelihood of significant weight gain within 6-8 months among patients on psychotropic drugs. Other studies also found higher prevalence of obesity among the female schizophrenic patients. Genetic polymorphisms, different dietary habits, lifestyle and environment explain the different likelihood of significant weight gain across races. It was well established that antipsychotics, particularly atypical antipsychotics was linked to weight gain. Each kg increase in weight represents a higher increase in percentage for underweight individuals as compared to obese individuals. [Disclaimer: Abstract text might vary slightly from what is displayed in the e-poster]
description: This poster was submitted to the 14th National Conference for Clinical Research (NCCR) on August 18-20 2021. https://nccrconference.com.my/
Extracting Japanese Domain and Technical Terms is Relatively Easy
Creators: name: Fung, Pascale
name: Kan, Min-Yen
name: Horita, Yurie
Publisher: name: Columbia University
Year: 1996
Subjects: Computer science
Information technology

description: We argue that the important task of extracting domain and technical terms is much easier in Japanese than is commonly believed, and that technical term extraction should and can be more widely used. We present a method which shows that the implementation of such a tool for Japanese can be remarkably simple due to the regularity and rigidity of morphosyntactic characteristics of Japanese technical terms. Our learning algorithm bootstraps from the tagged output of a Japanese tokenizer/tagger to learn syntactic and morphological properties of technical terms. We show that very simple linguistic patterns are reliable enough to yield high precision technical terms from tagged texts, even for terms which occur only once and are usually overlooked by English technical term extractors. In addition, by incorporating a model for unknown words, we are able to extract correct technical terms from words not properly tagged.
Extraction of emission parameters for large-area field emitters, using a technically complete Fowler-Nordheim-type equation
Creators: name: Forbes, Richard G.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: In papers on cold field electron emission from large area field emitters (LAFEs), it has become widespread practice to publish a misleading Fowler-Nordheim-type (FN-type) equation. This equation over-predicts the LAFE-average current density by a large highly-variable factor thought to usually lie between 1000 and 1000 000 000. This equation, although often referenced to FN's 1928 paper, is a simplified equation used in undergraduate teaching, does not apply unmodified to LAFEs, and does not appear in the 1928 paper. Technological LAFE papers often do not cite any theoretical work more recent than 1928, and often do not comment on the discrepancy between theory and experiment. This usage has occurred widely, in several high-profile American and UK applied-science journals, and in various other places. It does not inhibit practical LAFE development, but can give a misleading impression of potential LAFE performance to non-experts. This paper shows how the misleading equation can be replaced by a conceptually complete FN-type equation that uses three high-level correction factors. One of these, or a combination of two of them, may be useful as an additional measure of LAFE quality; this paper describes how to estimate factor values using experimental data. Suggestions are made for improved engineering practice in reporting LAFE results. Some of these should help to prevent situations arising whereby an equation appearing in high-profile applied-science journals is used to support statements that an engineering regulatory body might deem to involve professional negligence.
description: 36 pages, including two figures, and list of acronyms (to be electronic supplementary materiaL). Version scientifically equivalent to corrected proof for publication in Nanotechnology. Some minor typographical errors have been corrected
Coerced Markov Models For Cross-Lingual Lexical-Tag Relations
Creators: name: Fung, Pascale
name: Wu, Dekai
Publisher: name: Columbia University
Year: 1995
Subjects: Computer science
Information technology

description: We introduce the Coerced Markov Model (CMM) to model the relationship between the lexical sequence of a source language and the tag sequence of a target language, with the objective of constraining search in statistical transfer-based machine translation systems. CMMs differ from Hidden Markov Models in that state sequence assignments can take on values coerced from external sources. Given a Chinese sentence, a CMM can be used to predict the corresponding English tag sequence, thus constraining the English lexical sequence produced by a translation model. The CMM can also be used to score competing translation hypotheses in N-best models. Three fundamental problems for CMM designed are discussed. Their solutions lead to the training and testing stages of CMM.
Type-I superconductivity in ScGa3 and LuGa3 single crystals
Creators: name: Svanidze, E.
name: Morosan, E.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We present evidence of type-I superconductivity in single crystals of ScGa3 and LuGa3, from magnetization, specific heat, and resistivity measurements: low critical temperatures Tc = 2.1-2.2 K; field-induced secondto first-order phase transition in the specific heat, critical fields less than 240 Oe; and low Ginzburg-Landau coefficients κ approx 0.23 and 0.30 for ScGa3 and LuGa3, respectively, are all traits of a type-I superconducting ground state. These observations render ScGa3 and LuGa3 two of only several type-I superconducting compounds, with most other superconductors being type II (compounds and alloys) or type I (elemental metals and metaloids).
description: 5 pages, 6 figures
A pattern matching method for finding noun and proper noun translations from noisy parallel corpora
Creators: name: Fung, Pascale
Publisher: name: Columbia University
Year: 1995
Subjects: Computer science
Information technology

description: We present a pattern matching method for compiling a bilingual lexicon of nouns and proper nouns from unaligned, noisy parallel texts of Asian/Indo-European language pairs. Tagging information of one language is used. Word frequency and position information for high and low frequency words are represented in two different vector forms for pattern matching. New anchor point finding and noise elimination techniques are introduced. We obtained a 73.1% precision. We also show how the results can be used in the compilation of domain-specific noun phrases.
Rashba spin-orbit-interaction-based quantum pump in graphene
Creators: name: Bercioux, Dario
name: Urban, Daniel F.
name: Romeo, Francesco
name: Citro, Roberta
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We present a proposal for an adiabatic quantum pump based on a graphene monolayer patterned by electrostatic gates and operated in the low-energy Dirac regime. The setup under investigation works in the presence of inhomogeneous spin-orbit interactions of intrinsic- and Rashba-type and allows to generate spin polarized coherent current. A local spin polarized current is induced by the pumping mechanism assisted by the spin-double refraction phenomenon.
description: to appear in Appl. Phys. Lett. (2012)
Der SIMODONT Dental Trainer als sicheres Bewertungssystem und Lehrmodul in der zahnmedizinischen Ausbildung
Creators: name: Holter, Josefine
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2019
Subjects: subject: 610

description: Ziel der vorliegenden Untersuchung war es den SIMODONT Dental Trainer, ein Simulator zur Schulung von zahnmedizinischen Handlungsabläufen, als Lehrmodul und Bewertungssystem für die zahnmedizinische Ausbildung zu prüfen. Die drei Probandengruppen (Zahnmedizinstudierende des ersten und fünften Studienjahres der Martin-Luther-Universität Halle-Wittenberg, sowie approbierte Zahnärzte) durchliefen jeweils fünf praktische Aufgaben am Simulator und evaluierten diesen anschließend anhand eines Fragebogens. Die Auswertung der Ergebnisse erfolgte mit SPSS Version 24. Der Simulator wurde im Allgemeinen akzeptiert und als zusätzliches Lehr- bzw. Lernmodul in der Ausbildung geschätzt. Der Simulator ist zudem in der Lage ist zwischen Anfängern und erfahrenen Nutzern zu unterscheiden. Bestehende Erfahrungen mit Computer- und Videospielen nehmen keinen signifikanten Einfluss auf das Abschneiden bei den praktischen Versuchen. Der SIMODONT Dental Trainer ist ein geeignetes Lehrmodul für die zahnmedizinische Ausbildung. Anhand des Simulators lassen sich verschiedene Erfahrungslevel unterscheiden. Seine Einbindung in die Lehre sollte der Simulator vorwiegend im vorklinischen Bereich finden.
description: The aim of the present study was to examine the SIMODONT Dental Trainer, a simulator for the training of dental procedures, as a teaching module and grading system for dental education. The three groups of subjects (dentistry students of the first and fifth year of study at Martin-Luther-University Halle-Wittenberg, as well as licensed dentists) each completed five practical tasks on the simulator and subsequently evaluated it using a questionnaire. The evaluation of the results was done with SPSS version 24. The simulator has generally been accepted and appreciated as an additional training module in education. The simulator is also able to differentiate between beginners and experienced users. Existing experiences with computer and video games do not have a significant impact on the performance of the practical tests. The SIMODONT Dental Trainer is a suitable teaching module for dental training. Based on the simulator different experience levels can be differentiated. The simulator should primarily find its integration into teaching in the preclinical area.
On the Relations between Gravity and BF Theories
Creators: name: Freidel, Laurent
name: Speziale, Simone
Publisher: name: arXiv
Year: 2012
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We review, in the light of recent developments, the existing relations between gravity and topological BF theories at the classical level. We include the Plebanski action in both self-dual and non-chiral formulations, their generalizations, and the MacDowell-Mansouri action.
description: v3: journal typeset version
Innate immunity and inflammation in cystic fibrosis lung disease
Creators: name: Blohmke, Christoph Johannes
Publisher: name: University of British Columbia
Year: 2012

description: Inflammatory lung disease is the major life-limiting factor of cystic fibrosis (CF) and occurs through a self-sustaining cycle of airway obstruction, infection and inflammation. Although there is no consensus regarding the pathways responsible for the excessive inflammation, reducing lung-damaging pro-inflammatory responses are likely to be beneficial for CF patients. Using CF (IB3-1) and non-CF control (C38) respiratory cells, the host-pathogen interaction between the airway epithelium and the common CF pathogens P. aeruginosa and B. cepacia was investigated. Using purified Toll-like receptor (TLR) ligands and different knock-out strains of P. aeruginosa, TLR5 was identified as the receptor mediating much of the increased inflammatory response to CF pathogens. To validate TLR5 as an anti-inflammatory target, the disease modifying effects of the functionally relevant TLR5 c.1174C>T single nucleotide polymorphism (rs5744168) was analysed in approximately 80% of Canada’s CF population. rs5744168 encodes a premature stop codon and the T allele is associated with 45.5 – 76.3% reduction in flagellin responsiveness. CF patients carrying rs5744168 (CT or TT) had a significantly higher body mass index than CF patients homozygous for the common allele (CC) (p=0.044); however, similar improvements in lung function associated with the T allele were not statistically significant. Since TLR5 mediates much of the excessive inflammation to P. aeruginosa, it is of interest to understand the mechanisms underlying this dysregulated immune response. By combining gene expression arrays with network analyses and biochemical assays, ER stress was identified as a potential mechanism dysregulating p38 MAP kinase activity and leading to potentiated immune responses. Together, this thesis provides data underscoring the importance of TLR5-mediated excessive pro-inflammatory immune response by CF airway cells to P. aeruginosa. The association of the TLR5392STOP SNP with higher BMI in adult CF patients indicates an important role for TLR5 in CF disease severity. Finally, ER stress may potentiate the immune response to flagellin by signalling through p38 MAP kinase, supporting an emerging paradigm in which the imbalance of protein homeostasis can lead to altered signalling events. Strategies to inhibit either TLR5 signalling, ER stress signalling or to improve the cellular protein homeostasis may prove useful in treating life limiting inflammation in CF.
Window shifts, flop equivalences and Grassmannian twists
Creators: name: Donovan, Will
name: Segal, Ed
Publisher: name: arXiv
Year: 2012
Subjects: subject: Algebraic Geometry (math.AG)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics
subject: 14F05, 18E30 (Primary) 14M15 (Secondary)

description: We introduce a new class of autoequivalences that act on the derived categories of certain vector bundles over Grassmannians. These autoequivalences arise from Grassmannian flops: they generalize Seidel-Thomas spherical twists, which can be seen as arising from standard flops. We first give a simple algebraic construction, which is well-suited to explicit computations. We then give a geometric construction using spherical functors which we prove is equivalent.
description: Improved structure and formatting. Minor edits to some explanations. Added acknowledgements and addresses. 38 pages, 7 figures
Untersuchungen zur Expression und prognostischen Bedeutung von mikroRNA im Speichel bei Patienten mit Plattenepithelkarzinomen im Kopf-Hals-Bereich
Creators: name: Vorwerk, Freya Constanze
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2019
Subjects: subject: 616

description: Bösartige Kopf-Hals-Tumoren stehen auf Platz sechs der weltweit am häufigsten vorkommenden Malignome. Die Fünf-Jahres-Überlebensrate stagniert seit Jahrzehnten. Ein vielversprechender molekularer Marker könnte mikroRNA darstellen. Ziel war der Nachweis verschiedener spezifischer mikroRNA im Speichel während einer kurativen Radio-Chemo-Therapie sowie im Follow-up. Ausgewählt wurden Patienten, die an einem Plattenepithelkarzinom im Kopf-Hals-Bereich erkrankten. Insgesamt wurden 83 Speichelproben zu verschiedenen Zeitpunkten gesammelt und auf zehn bekannte, spezifische mikroRNA (miR-93, miR-125a, miR-142-3p, miR-200a, miR-203, miR-213, let-7a, let-7b, let-7g und let-7i), die mit Plattenepithelkarzinomen assoziiert sind, mittels quantitativer Real-Time-PCR analysiert. Alle ausgewählten mikroRNA konnten in unterschiedlichen Expressionen nachgewiesen werden. Anhand der Ergebnisse erscheinen insbesondere die miR-93 und die miR-200a für klinische Untersuchungen für das Erkennen von Rezidiven bei Patienten mit tumortherapeutischer Kopf-Hals assoziierter Radio-Chemo-Therapie geeignet zu sein.
description: Head and neck squamous cell carcinoma is the 6th most malignant tumor entity worldwide and has exhibited a 5-year mortality of approximately 50%. For the therapy monitoring and successful management of this tumor entity new and easily accessible biomarkers are greatly needed. The aim of the study was to determine whether and to what extent microRNAs, a class of small regulatory RNAs, are detectable in saliva post-radiation therapy. The expres- sion and feasibility as therapy monitoring marker of the microRNAs were analyzed by RT-qPCR in 83 saliva samples collected at several time points pre-, during and post-radiotherapy treatment. Ten head and neck squamous cell carcinoma- or radiation-associated microRNAs (miR-93, miR-125a, miR-142-3p, miR-200a, miR-203, miR-213, let-7a, let-7b, let-7g and let-7i) were analyzed. All were detectable to a different extent in the saliva of the patients. miR-93 and miR-200a were significantly higher expressed 12 months post- radiotherapy than at baseline (p=0.047 and p=0.036). These results point towards miR-93 and miR-200a as biomarkers for the treatment monitoring post-radiation of head and neck squamous cell carcinoma.
The Universal Askey-Wilson Algebra and the Equitable Presentation of $U_q(\mathfrak{sl}_2)$
Creators: name: Terwilliger, Paul
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Algebra (math.QA)
subject: Rings and Algebras (math.RA)
subject: FOS: Mathematics
subject: 33D80, 33D45

description: Around 1992 A. Zhedanov introduced the Askey-Wilson algebra AW(3). Recently we introduced a central extension $Δ$ of AW(3) called the universal Askey-Wilson algebra. In this paper we discuss a connection between $Δ$ and the quantum algebra $U_q(\mathfrak{sl}_2)$. Our main result is an algebra injection from $Δ$ into a relative of $U_q(\mathfrak{sl}_2)$; the relative is obtained from $U_q(\mathfrak{sl}_2)$ by adjoining three mutually commuting indeterminates. We describe the injection using the equitable presentation of $U_q(\mathfrak{sl}_2)$
description: misprint in Lemma 7.1 is corrected
Magnetic Exciton Mediated Superconductivity in the Hidden-Order Phase of URu2Si2
Creators: name: Kusunose, Hiroaki
Publisher: name: arXiv
Year: 2011
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We propose the magnetic exciton mediated superconductivity occurring in the enigmatic hidden-order phase of URu2Si2. The characteristic of the massive collective excitation observed only in the hidden-order phase is well reproduced by the antiferro hexadecapole ordering model as the trace of the dispersive crystalline-electric-field excitation. The disappearance of the superconductivity in the high-pressure antiferro magnetic phase can naturally be understood by the sudden suppression of the magnetic-exciton intensity. The analysis of the momentum dependence of the magnetic-exciton mode leads to the exotic chiral d-wave singlet pairing in the Eg symmetry. The Ising-like magnetic-field response of the mode yields the strong anisotropy observed in the upper critical field even for the rather isotropic 3-dimensional Fermi surfaces of this compound.
description: 5 pages, 4 figures
Extracting Social Networks from Literary Fiction
Creators: name: Elson, David K.
name: McKeown, Kathleen
name: Dames, Nicholas J.
Publisher: name: Columbia University
Year: 2010
Subjects: Computer science

description: We present a method for extracting social networks from literature, namely, nineteenth-century British novels and serials. We derive the networks from dialogue interactions, and thus our method depends on the ability to determine when two characters are in conversation. Our approach involves character name chunking, quoted speech attribution and conversation detection given the set of quotes. We extract features from the social networks and examine their correlation with one another, as well as with metadata such as the novel’s setting. Our results provide evidence that the majority of novels in this time period do not ﬁt two characterizations provided by literacy scholars. Instead, our
results suggest an alternative explanation for differences in social networks.
Diversität, antagonistisches Potential und Pathogenität von Mikroorganismen aus dem Boden und der Phyllosphäre von Apfelanlagen : [kumulative Dissertation]
Creators: name: Kucheryava, Nataliya
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2007
Subjects: subject: Biozönose
subject: Mikroorganismus
subject: Apfelproduktion
subject: 577

description: Diversität der Gemeinschaften von Mikroorganismen in der Phyllosphäre und im Boden der Apfelanlagen wurde bezüglich des metabolischen, antagonistischen oder pathogenen Potentials ermittelt. Die aus den ausgewählten Umwelthabitaten gewonnenen mikrobiellen Isolate oder metagenomische DNA wurden auf biologische Aktivitäten und Gene für biologisch aktive Substanzen oder Pathogenitätsfaktoren untersucht. Für die Identifizierung der Gencluster für Wirkstoffsynthesen von einem besonders aktiven antagonistischen Umweltisolat B. subtilis A1/3 wurde genomische Genbank in einem neu konstruierten E. coli-Bacillus-Shuttle-Cosmidvektor hergestellt und der komplette Gencluster für die Biosynthese von Bacillomycin L identifiziert. Für die Identifizierung und Expressionsanalyse von eukaryotischen Pathogenese-relevanten Genen wurde eine cDNA-Genbank aus einem in vitro etablierten Infektionsmodell oder aus mit V. inaequalis infizierten Pflanzen angelegt. Zwei bisher unbekannte Gene, cin1 und cin3, wurden identifiziert, die für neuartige Proteine mit bisher unbekannter Funktion kodieren und während der biotrophen Infektion in der Pflanze exprimiert werden.
description: The diversity of the microbial communities in the phyllosphere and in soil of apple orchards was investigated to access their metabolic, antagonistic or pathogenic potential. The obtained microbial isolates or metagenomic DNA derived from the given environmental habitats were investigated for biologic activity and genes for antimicrobial compounds or pathogenicity factors. To access the genes involved in the production of antimicrobial agents, a genomic cosmid library of an environmental isolate B. subtilis A1/3 with a broad antimicrobial activity spectrum was constructed in a novel E. coli-Bacillus shuttle cosmid vector resulting in successful identification of the complete bacillomycin L gene cluster. For the discovery and expression analysis of the eukaryotic pathogenesis-related genes, a cDNA library was prepared from an in vitro established infection model or from plants infected with V. inaequalis. Two up-regulated fungal, hitherto unknown, potentially pathogenesis-related genes, cin1 and cin3, were identified which encode the putative proteins with as yet unknown functions and are specifically expressed in the pathogen during biotrophic infection.
Superluminal neutrino and spontaneous breaking of Lorentz invariance
Creators: name: Klinkhamer, F. R.
name: Volovik, G. E.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Generally speaking, the existence of a superluminal neutrino can be attributed either to re-entrant Lorentz violation at ultralow energy from intrinsic Lorentz violation at ultrahigh energy or to spontaneous breaking of fundamental Lorentz invariance (possibly by the formation of a fermionic condensate). Re-entrant Lorentz violation in the neutrino sector has been discussed elsewhere. Here, the focus is on mechanisms of spontaneous symmetry breaking.
description: 4 pages, v4: published version
A Lightweight Intelligent Virtual Cinematography System for Machinima Production
Creators: name: Elson, David K.
name: Riedl, Mark
Publisher: name: Columbia University
Year: 2007
Subjects: Computer science
Motion pictures--Production and direction
Artificial intelligence

description: Machinima is a low-cost alternative to full production filmmaking. However, creating quality cinematic visualizations with existing machinima techniques still requires a high degree of talent and effort. We introduce a lightweight artificial intelligence system, Cambot, that can be used to assist in machinima production. Cambot takes a script as input and produces a cinematic visualization. Unlike other virtual cinematography systems, Cambot favors an offline algorithm coupled with an extensible library of specific modular and reusable facets of cinematic knowledge. One of the advantages of this approach to virtual cinematography is a tight coordination between the positions and movements of the camera and the actors.
Plastidäre Vorläuferproteine im Cytosol : Import vs. Degradation
Creators: name: Grimmer, Julia
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2019
Subjects: subject: Ackerschmalwand
subject: Chloroplast
subject: Cytosol
subject: Proteasom
subject: 572

description: In Arabidopsis thaliana ist der Großteil plastidärer Proteine im Zellkern kodiert und wird im Cytosol als Vorläuferproteine synthetisiert. Hier unterliegen Vorläuferproteine Modifikationen und Regulationen, die weitestgehend unbekannt sind. In dieser Arbeit konnte gezeigt werden, dass die zweite Aminosäure von Vorläuferproteinen über die Art der N-terminalen Modifikationen bestimmt und Einfluss auf die Importeffizienz oder Stabilität in transient transformierten Protoplasten hat. Des Weiteren führte die Inhibierung des 26S Proteasoms zur Akkumulation von Vorläuferproteinen, was eine Verknüpfung des Ubiquitin-Proteasom-Systems (UPS) und der Degradation von Vorläuferproteinen bestärkte. Die Mutation der regulatorischen Proteasom-Untereinheit Rpn8A in Kombination mit einem Importdefekt in der Doppelmutante rpn8a ppi2 zeigte eine partielle Komplementation des Plastidenphänotyps von ppi2. Proteomanalysen zeigten unter anderem erhöhte Mengen an Proteinen der Photosynthese. Die Ergebnisse wiesen auf einen regulatorischen Effekt des Proteasoms auf die Plastidenbiogenese hin. Die Stabilisierung von Vorläuferproteinen im Cytosol sowie die Anpassung an Stress könnten dabei von Bedeutung sein.
description: The majority of Arabidopsis thaliana plastid proteins is nuclear encoded and has to be synthesized in the cytosol as preproteins. Plastid preproteins are modified in the cytosol and subject to quality control prior to their organellar translocation. We show here that the second amino acid of plastid preproteins determines N-terminal modifications and influences import efficiency or stability in transiently transformed protoplasts. Further inhibition of the 26S proteasome leads to accumulation of preproteins, supporting a connection between the ubiquitin-proteasome system (UPS) and preprotein degradation. The mutation of the regulatory proteasome subunit Rpn8A in the plastid protein import mutant 2 (ppi2) background leads to partial rescue of the ppi2 plastid phenotype. A proteome-wide comparison of ppi2 with the rpn8a ppi2 double mutant showed among other things increased abundance of photosynthetic proteins. These results refer to regulatory effects of the proteasome on the plastid biogenesis. In this process preprotein stability in the cytosol and adaption to stress could play a leading role.
A Tool for Deep Semantic Encoding of Narrative Texts
Creators: name: Elson, David K.
name: McKeown, Kathleen
Publisher: name: Columbia University
Year: 2009
Subjects: Computer science

description: We have developed a novel, publicly available annotation tool for the semantic encoding of texts, especially those in the narrative domain. Users can create formal propositions to represent spans of text, as well as temporal relations and other aspects of narrative. A built-in natural language generation component regenerates text from the formal structures, which eases the annotation process. We have run collection experiments with the tool and shown that non-experts can easily create semantic encodings of short fables. We present this tool as a stand-alone, reusable resource for research in semantics in which formal encoding of text, especially in a narrative form, is required.
A goal programming algorithm to incorporate the Columbia river non-power flow requirements in the Columbia River treaty model
Creators: name: Mamun, Abdullah Al
Publisher: name: University of British Columbia
Year: 2012

description: Canada built and operates three large dams and the U.S. built and operates one dam in the Columbia River based on the Columbia River Treaty (CRT) which was signed in 1961 and ratified in 1964. Annual Operating Plan developed by two Entities does not include non-power requirements, unless they are mutually agreed upon by both Entities. Supplemental Operating Agreements (SOA) have been negotiated and implemented since the 1990s to meet the U.S. and the Canadian power, fish, wildlife and/or recreation needs. The objective of this research was to develop a multi-objective optimization model to deal with multiple and conflicting objectives. The Columbia River Treaty Model (CRTM) developed by BC Hydro was modified by this research to incorporate three non-power requirements that are agreed upon by both Entities. The new model, which utilized the Goal Programming technique to solve the multi-objective reservoir optimization problem, was used to perform a number of case studies in order to investigate the impacts of incorporating different non-power requirements onto the BC Hydro system. Specific minimum outflow at the border in January affects the level of fulfillment of three non-power requirements. The first requirement is the Flow Augmentation requirement to aid in the downstream migration of Salmon in the U.S. The second requirement is the flow requirements below the Arrow reservoir to protect Whitefish eggs during the spawning and hatching periods. The third requirement is the specific flow requirement to provide enough water cover for the Trout spawning downstream of Arrow. The model uses three prioritized objectives of which the Flow Augmentation and Whitefish are of highest priority followed by the Trout Spawning and the maximization of BC Hydro revenues. Four Arrow minimum flow scenarios were compared with the Treaty operation. The study results show that lowering the minimum Arrow flow limit in January increases the satisfaction level of the Flow Augmentation and Whitefish non-power requirements. However, it may be in conflict with the power requirement of meeting Pacific North-west winter peak loads. Unless additional flow is required for Flow Augmentation during April, it has no effect on Trout spawning.
Tests of AdS$_4$/CFT$_3$ correspondence for $\mathcal{N}=2$ chiral-like theory
Creators: name: Gang, Dongmin
name: Hwang, Chiung
name: Kim, Seok
name: Park, Jaemo
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We investigate the superconformal index and the partition function for the chiral-like Chern-Simons-matter theory proposed for M2-branes probing the cones over $M^{3,2}$ and find perfect agreements with the gravity index and the gravitational free energy.
description: 16 pages, 1 figure; typos corrected, references added
DHBenelux 2018: round table session 'Integrating libraries and Digital Humanities'
Creators: name: , Cock
name: Claeyssens
name: Ten Dolle
name: Companjen
name: Knaap, Van Der
Publisher: name: Zenodo
Year: 2019

description: Abstract and report of the round table session at DHBenelux 2018 'Integrating libraries and Digital Humanities'.
Extending and Evaluating a Platform for Story Understanding
Creators: name: Elson, David K.
name: McKeown, Kathleen
Publisher: name: Columbia University
Year: 2009
Subjects: Computer science

description: We summarize recent developments in our platform for symbolically representing and reasoning over human narratives. The expressive range of the system is bolstered by the infusion of a large library of knowledge frames, including verbs, adjectives, nouns and adverbs,
from external linguistic resources. Extensions to the model itself include alternate timelines (imagined states for goals, plans, beliefs and other modalities), hypotheticals, modiﬁers and connections between instantiated frames such as causality. We describe a corpus collection experiment that evaluates the usability of the graphical encoding interface, and measure the inter-annotator agreement yielded by our novel representation and tool.
Deep Inelastic Scattering from Holographic Spin-One Hadrons
Creators: name: Koile, Ezequiel
name: Macaluso, Sebastian
name: Schvellinger, Martin
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study deep inelastic scattering structure functions from hadrons using different holographic dual models which describe the strongly coupled regime of gauge theories in the large $N$ limit. Particularly, we consider scalar and vector mesons obtained from holographic descriptions with fundamental degrees of freedom, corresponding to ${\cal {N}}=2$ supersymmetric and non-supersymmetric Yang-Mills theories. We explicitly obtain analytic expressions for the full set of eight structure functions, i.e., $F_1$, $F_2$, $g_1$, $g_2$, $b_1$, $b_2$, $b_3$, $b_4$, arising from the standard decomposition of the hadronic tensor of spin-one hadrons. We obtain the relations $2 F_1 = F_2$ and $2 b_1 = b_2$. In addition, we find $b_1 \sim {\cal {O}}(F_1)$ as suggested by Hoodbhoy, Jaffe and Manohar for vector mesons. Also, we find new relations among some of these structure functions.
description: 41 pages, 4 figures; a figure added, added references, minor changes
Untersuchungen zur genetischen Verankerung von Störungen der Reproduktionsorgane der Milchkuh anhand von Gesundheitsdaten des GKUHplus Projekts
Creators: name: Müller-Rätz, Vincent
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2019
Subjects: subject: 636

description: Ziel dieser Arbeit war es Diagnosedaten aus Praxisbetrieben zu nutzen und Merkmale für Fruchtbarkeitsstörungen bei der Rasse Holstein zu definieren, um dann Erblichkeiten und Korrelationen zu anderen Merkmalen zu schätzen. Die bei binärer bzw. stetiger Merkmalsdefinition in den Ein- und Zweimerkmalsmodellen geschätzten Erblichkeiten fielen für die Fruchtbarkeitsstörungen erwartungsgemäß gering aus (0,01 - 0,05). Random-Regression-Modellen wurden verwendet um die Diagnose Daten im Verlauf der Laktation darstellen zu können. Für spezifischere Merkmale (Diagnosen) wurden höher Erblichkeiten als für zusammengefasste Merkmale geschätzt. Durch die Anwendung der in dieser Arbeit vorgestellten Erblichkeiten für einzelne Fruchtbarkeitsstörungen und der Berücksichtigung der dargestellten genetischen Korrelationen zwischen den Fruchtbarkeits- und Leistungsmerkmalen kann ein Beitrag zur nachhaltigen Verbesserung der Fruchtbarkeit beim Deutschen Holstein geleistet werden.
description: The aim of this study was to use diagnostic data from dairy farms to define traits for fertility disorders in the Holstein cattle and to estimate heritability and correlations to other health and yield traits. As expected, the heritability’s estimated with binary or continuous trait definition for fertility disorders was low (0.01 - 0.05). Random regression models were used to represent the diagnosis data during lactation. For more specific traits (diagnoses) higher heritability’s were estimated than for pooled traits. By applying the hereditary features presented in this work for individual fertility disorders and taking into account the presented genetic correlations between the fertility and performance characteristics, a contribution to the sustainable improvement of fertility in the Holstein cattle is possible.
Quatuor pour temps incertains (8th Movement-SCORE)
Creators: name: Elia, Anthony J.
Publisher: name: Columbia University
Year: 2013
Subjects: Prayer

description: The “Quatuor pour temps incertains” is a Quartet for Bb Clarinet, Violin, ‘Cello, and Piano, inspired by the work “Quatuor pour la fin du temps” by Oliver Messiaen. The present work is also in 8-movements, and composed with the same instrumentation as Messiaen’s work. The parts are based on aspects of life, memory, spirit, and prayer, for example, though not directly tied to Messiaen’s biblical inspirations. The composer of the present work first got the idea to write this “Quatuor,” after reading a piece about Messiaen by clarinetist Nurhak Tuncer, for whom this was written. The 8-movements of this piece include: Part 1: Incertitude, Part 2: Fragilté, Part 3: Recherche, Part 4: E’quilibre, Part 5: Esprit, Part 6: Repos, Part 7: Prière, Part 8: Résurrection. (All individual parts for the 8 movements will be available on Academic Commons).
title: Логика юридического доказывания
Creators: name: ELS IPR BOOKS
Publisher: name: Северо-Кавказский федеральный университет
Year: 2023

description: Практикум составлен в соответствии с требованиями ФГОС ВО и представляет учебно-методические разработки тем для практических занятий. Утвержден на заседании кафедры правовой культуры и защиты прав человека. Протокол № 9 от 24 апреля 2023 г. Предназначен для студентов направления подготовки 40.03.01 Юриспруденция, направленности (профили): «Государственно-правовой», «Гражданско-правовой», «Уголовно-правовой», «Международно-правовой», «Правозащитная деятельность», «Финансово-правовой», «Правовая жизнь и юридическая деятельность», «Экологическое и природоресурсное право», «Технологическая юриспруденция».
Derivative Chameleons
Creators: name: Noller, Johannes
Publisher: name: arXiv
Year: 2012
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider generalized chameleon models where the conformal coupling between matter and gravitational geometries is not only a function of the chameleon field ϕ, but also of its derivatives via higher order co-ordinate invariants. Specifically we consider the first such non-trivial conformal factor A(ϕ,X), where X is the canonical kinetic term for ϕ. The associated phenomenology is investigated and we show that such theories have a new generic mass-altering mechanism, potentially assisting the generation of a sufficiently large chameleon mass in dense environments. The most general effective potential is derived for such derivative chameleon setups and explicit examples are given. Interestingly this points us to the existence of a purely derivative chameleon protected by a shift symmetry for ϕ. We also discuss potential ghost-like instabilities associated with mass-lifting mechanisms and find another, mass-lowering and instability-free, branch of solutions. This suggests that, barring fine-tuning, stable derivative models are in fact typically anti-chameleons that suppress the field's mass in dense environments. Furthermore we investigate modifications to the thin-shell regime and prove a no-go theorem for chameleon effects in non-conformal geometries of the disformal type.
description: 28 pages, 4 figures
Interlingual Annotation of Multilingual Text Corpora
Creators: name: Farwell, David
name: Helmreich, Stephen
name: Reeder, Florence
name: Miller, Keith
name: Levin, Lori
name: Hovy, Eduard
name: Dorr, Bonnie
name: Habash, Nizar Y.
name: Mitamura, Teruko
name: Rambow, Owen
name: Siddharthan, Advaith
Publisher: name: Columbia University
Year: 2004
Subjects: Information technology
Computer science

description: This paper describes a multi-site project to annotate six sizable bilingual parallel corpora for interlingual content. After presenting the background and objectives of the effort, we will go on to describe the data set that is being annotated, the interlingua representation language used, an interface environment that supports the annotation task and the annotation process itself. We will then present a preliminary version of our evaluation methodology and conclude with a summary of the current status of the project along with a number of issues which have arisen.
Transport and scattering in inhomogeneous quantum wires
Creators: name: Sedlmayr, N.
name: Ohst, J.
name: Affleck, I.
name: Sirker, J.
name: Eggert, S.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We consider scattering and transport in interacting quantum wires that are connected to leads. Such a setup can be represented by a minimal model of interacting fermions with inhomogeneities in the form of sudden changes in interaction strength and/or velocity. The inhomogeneities generally cause relevant backscattering, so it is a priori unclear if a perfectly ballistic quantum wire can exist in the low temperature limit. We are able to identify such a perfectly conducting fixed point even for large abrupt changes, which in the considered model corresponds to a velocity matching condition. The general position dependent Green's function is calculated in the presence of a sudden change, which is confirmed numerically with high accuracy. The exact form of the interference pattern in the form of density oscillations around inhomogeneities can be used to estimate the effective strength of local backscattering sources.
description: 5 pages, 3 figures. Published version. For more information and the latest version see http://www.physik.uni-kl.de/eggert/papers/index.html
Entanglement Renyi Entropies in Conformal Field Theories and Holography
Creators: name: Fursaev, Dmitri V.
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: An entanglement Renyi entropy for a spatial partition of a system is studied in conformal theories which admit a dual description in terms of an anti-de Sitter gravity. The divergent part of the Renyi entropy is computed in 4D conformal N=4 super Yang-Mills theory at a weak coupling. This result is used to suggest a holographic formula which reproduces the Renyi entropy at least in the leading approximation. The holographic Renyi entropy is an invariant functional set on a codimension 2 minimal hypersurface in the bulk geometry. The bulk space does not depend on order $n$ of the Renyi entropy. The holographic Renyi entropy is a sum of local and non-local functionals multiplied by polynomials of $1/n$.
description: 22 pages, 1 figure, v2 (journal version): typos are corrected, new formulas and comments are added to compare with results of [14] and other works
Characterization of the boundary diffusion mechanism for the Helix-Coil transition in peptides by Triplet-Triplet energy transfer
Creators: name: Wicht, Stefan
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2019
Subjects: subject: Proteinfaltung
subject: Helix-Knäuel-Umwandlung
subject: Diffusionskoeffizient
subject: 572

description: Helix-Coil Dynamiken werden durch eine 1-D Diffusion der Helix-Coil Grenze entlang des Peptidrückrats beherrscht. Ziel dieser Arbeit war eine präzisere Bestimmung des Diffusionskoeffizienten für die Grenzdiffusion, um den Mechanismus für den Helix-Coil Übergang genauer zu charakterisieren. Dabei wurde der Einfluss der Lösungsmittelviskosität und Temperatur auf den Diffusionskoeffizienten durch Triplett-Triplett Energie Transfer Messungen untersucht. Die Ergebnisse verdeutlichten, dass der Prozess nicht vollständig diffusionskontrolliert ist, sondern signifikante Energiebarrieren besitzt. Des Weiteren wurde der Einfluss von geladenen Capping Motiven auf die Helixstabilität und Dynamik untersucht. Es konnte gezeigt werden, dass geladene Capping Motive α-Helices durch elektrostatische Wechselwirkungen mit dem Helix-Dipol stabilisieren. Die Stabilisierung beruht auf einer Verlängerung des Diffusionsweges der Grenzdiffusion, was zu einer Verlangsamung der Helixentfaltung im Zentrum führt.
description: Equilibrium helix-coil dynamics are governed by a 1-D diffusion of the helix-coil boundary along the peptide backbone. This study aims to determine a more reliable diffusion coefficient for helix-coil boundary diffusion using triplet-triplet energy transfer. In order to further characterize the boundary diffusion mechanism for the helix-coil transition in peptides, the effect of solvent viscosity and temperature on the diffusion coefficient for boundary diffusion was analyzed. The results indicated that boundary diffusion is not exclusively limited by solvent friction but encounters significant energy barriers. Moreover, the effect of capping motifs on helix-coil dynamics and stability was investigated by differently charged N- and C-capping motifs. It could be demonstrated that charged capping motifs stabilize α-helices by electrostatic interactions with the helix dipole and thereby lead to longer diffusion distances of the boundary which slow down helix unfolding in central regions.