cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Regulation of a Calcium-dependent Tyrosine Kinase in Vascular Smooth Muscle Cells by Angiotensin II and Platelet-derived Growth Factor: DEPENDENCE ON CALCIUM AND THE ACTIN CYTOSKELETON
Creators: name: Diliberto, Pamela A.
name: Hunter, Debra
name: He, Yaqin
name: Graves, Lee M.
name: Li, Xiong
name: Herman, Brian
name: Harding, Timothy
name: Earp, H. Shelton
name: Brinson, Amy E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: A novel, p125FAK homologue, CADTK, has been detected in neural, epithelial, or hematopoietic cells but not in fibroblasts. We now demonstrate CADTK expression in a mesenchymal cell, rat aortic smooth muscle cells (RSMC). Angiotensin II (Ang II) or platelet-derived growth factor (PDGF-BB and PDGF-AA) markedly stimulated CADTK tyrosine phosphorylation in RSMC but did not affect p125FAK phosphorylation. The PDGF-depedent CADTK tyrosine phosphorylation was slower and more prolonged than that of Ang II, correlating well with the differential effects of these agonists on cytosolic calcium ([Ca2+]i) signaling. An intracellular calcium chelator inhibited both the rapid and sustained activation of CADTK by Ang II and PDGF. Extracellular calcium chelation inhibited the PDGF-stimulated increase in CADTK tyrosine phosphorylation as well as the sustained (but not the early) activation by Ang II. In contrast, p125FAK tyrosine phosphorylation was maximal in quiescent, adherent RSMC and was not affected by incubation with EGTA. Depletion of protein kinase C activity partially inhibited both the Ang II- and PDGF-induced CADTK tyrosine phosphorylation. Additional results confirm a relation between CADTK and the cytoskeleton. First, the tyrosine phosphorylation of paxilin correlated with activation of CADTK; this increase was inhibited by EGTA. Second, cytochalasin D blocked the PDGF- or Ang II-stimulated tyrosine phosphorylation of CADTK, suggesting a role for the cytoskeleton in agonist-dependent CADTK activation. Third, immunofluorescence analysis of CADTK localization demonstrated actin-like cytoskeleton staining extending into focal contacts. These results suggest that in mesenchymal cells, CADTK is localized to and activated by an actin cytoskeleton-dependent mechanism; a mechanism that is regulated in a calcium and protein kinase C-dependent manner independently of p125FAK.
Supplementary figures and tables from Regional climate and local-scale biotic acceptance explain native–exotic diversity relationships in Australian annual plant communities
Creators: name: Isaac. R. Towers
name: John. M. Dwyer
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Environmental Science
subject: Ecology
subject: FOS: Biological sciences

description: Figure S1, S2, S3 and Table S1, S2, S3, S4, S5, S6
Genome-wide networks reveal emergence of epidemic strains of Salmonella Enteritidis
Creators: name: Svahn, Adam J.
name: Chang, Sheryl L.
name: Rockett, Rebecca J.
name: Cliff, Oliver M.
name: Wang, Qinning
name: Arnott, Alicia
name: Ramsperger, Marc
name: Sorrell, Tania C.
name: Sintchenko, Vitali
name: Prokopenko, Mikhail
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantitative Methods (q-bio.QM)
subject: Populations and Evolution (q-bio.PE)
subject: FOS: Biological sciences

description: Objectives: To enhance monitoring of high-burden foodborne pathogens, there is opportunity to combine pangenome data with network analysis. Methods: Salmonella enterica subspecies Enterica serovar Enteritidis isolates were referred to the New South Wales (NSW) Enteric Reference Laboratory between August 2015 and December 2019 (1033 isolates in total), inclusive of a confirmed outbreak. All isolates underwent whole genome sequencing. Distances between genomes were quantified by in silico MLVA as well as core SNPs, which informed construction of undirected networks. Prevalence-centrality spaces were generated from the undirected networks. Components on the undirected SNP network were considered alongside a phylogenetic tree representation. Results: Outbreak isolates were identifiable as distinct components on the MLVA and SNP networks. The MLVA network based centrality/prevalence space did not delineate the outbreak, whereas the outbreak was clearly delineated in the SNP network based centrality/prevalence space. Components on the undirected SNP network showed a high concordance to the SNP clusters based on phylogenetic analysis. Conclusions: Bacterial whole genome data in network based analysis can improve the resolution of population analysis. High concordance of network components and SNP clusters is promising for rapid population analyses of foodborne Salmonella spp. due to the low overhead of network analysis.
The Warburg Institute Classification Scheme (1935)
Creators: name: Wind, Edgar
Publisher: name: La Rivista di Engramma
Year: 2023
Subjects: Warburg Library
Warburg Institute
Classification
Edgar Wind

description: In this contribution, first published in “The Library Association Record” in 1935, Edgar Wind briefly explains the system of classification used in the Warburg Library, listing its merits and the issues that new fields of study will bring to it.
Leadership for school improvement
Creators: name: Anderson, Anne
Publisher: name: Australian Catholic University
Year: 2016

description: "This study has emerged from an international interest and movement towards school improvement. The process of school improvement concerns itself with the concepts of change and accountability within school systems as well as the impact of leadership within these processes. The purpose of this study is to explore the influence of leadership on school improvement in Catholic secondary schools. Specifically, it addresses how leadership was seen to influence both school improvement and the understandings of leadership of people involved in school improvement within Catholic secondary schools in Sydney. The research asked the question: How does leadership influence school improvement? It explored an understanding of the views, experiences and perspectives of teachers, middle managers and executive regarding the influence of leadership practices on school improvement within secondary schools. With this aim in mind the epistemological framework of constructionism was adopted using the theoretical perspective of symbolic interactionism and case study methodology. The case study approach was chosen as it allowed an understanding of the phenomenon of leadership experienced by the participants within school improvement. Multiple data collection methods of survey, semi-structured interviews and documents analysis were employed to allow the researcher to look into and detail the complex and multifaceted interactions of the teachers, middle managers and executive to gain an understanding of how these participants experienced leadership and how it impacted on their role, responsibilities, and sense of ownership of school improvement. This research has shown that certain elements of leadership play a vital role in influencing change for school improvement. A proposed model for school improvement was found that focuses on seven elements of leadership that influence school improvement: establishing a core team to lead the process, identifying a clear vision and strategic direction, priority given to shared leadership which is enhanced by a collaborative approach, commitment and alignment of values, developing a strong learning culture that focuses on continual improvement and support through reflection and evaluation of improvement processes. These elements, when combined, provide a fertile environment in which principals and teachers can take collective responsibility for change to improve schools. Further it recognises that leadership between principals and teachers needs to be shared as both have roles and expertise that can influence change for school improvement."
Results, when excluding the 36-year-old odour donor from the analyses. from The scent of attractiveness: levels of reproductive hormones explain individual differences in women's body odour.
Creators: name: Lobmaier, Janek S.
name: Fischbacher, Urs
name: Wirthmüller, Urs
name: Knoch, Daria
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Individuals are thought to have their own distinctive body odour which reportedly plays an important role in mate choice. In the present study we investigated individual differences in body odours of women and examined whether some women generally smell more attractive than others or whether odour preferences are a matter of individual taste. We then explored whether levels of reproductive hormones explain women's body odour attractiveness, to test the idea that body odour attractiveness may act as a chemosensory marker of reproductive fitness. Fifty-seven men rated body odours of 28 healthy, naturally cycling women of reproductive age. We collected all odours at peak fertility to control for menstrual cycle effects on body odour attractiveness. Women's salivary oestradiol, progesterone, testosterone and cortisol levels were assessed at the time of odour collection to test whether hormone levels explain body odour attractiveness. We found that the men highly agreed on how attractive they found women's body odours. Interestingly, women's body odour attractiveness was predicted by their oestradiol and progesterone levels: the higher a woman's levels of oestradiol and the lower her levels of progesterone, the more attractive her body odour was rated. In showing that women's body odour attractiveness is explained by levels of female reproductive hormones, but not by levels of cortisol or testosterone, we provide evidence that body odour acts as a valid cue to potential fertility.
Roles of Residues in Mammalian Mitochondrial Elongation Factor Ts in the Interaction with Mitochondrial and Bacterial Elongation Factor Tu
Creators: name: Zhang, Yuelin
name: Spremulli, Linda L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: The crystal structure of the complex between Escherichia coli elongation factors Tu and Ts (EF-Tu.Ts) and subsequent mutagenesis work have provided insights into the roles of a number of residues in E. coli EF-Ts in its interaction with EF-Tu. The corresponding residues in bovine mitochondrial EF-Ts (EF-Tsmt) have been mutated. The abilities of the resulting EF-Tsmt derivatives to stimulate the activities of both E. coli and mitochondrial EF-Tu have been tested. Mutation of several residues in EF-Tsmt corresponding to amino acids important for the activity of E. coli EF-Ts has little or no effect on the activity of the mitochondrial factor, suggesting that these factors may use somewhat different mechanisms to promote guanine nucleotide exchange. In general, mutations that reduce the strength of the interaction between EF-Tsmt and E. coli EF-Tu increase the ability of EF-Tsmt to stimulate the activity of the bacterial factor. In contrast, these mutations tend to reduce the ability of EF-Tsmt to stimulate the activity of EF-Tumt. For example, F19A/I20A and H176A derivatives of EF-Tsmt are as active as E. coli EF-Ts in simulating E. coli EF-Tu. However, these mutations significantly decrease the ability of EF-Tsmt to stimulate EF-Tumt.
Noncommutative geometry, Grand Symmetry and twisted spectral triple
Creators: name: Devastato, Agostino
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: In the noncommutative geometry approach to the standard model we discuss the possibility to derive the extra scalar field sv- initially suggested by particle physicist to stabilize the electroweak vacuum - from a "grand algebra" that contains the usual standard model algebra. We introduce the Connes-Moscovici twisted spectral triples for the Grand Symmetry model, to cure a technical problem, that is the appearance, together with the field sv, of unbounded vectorial terms. The twist makes these terms bounded, and also permits to understand the breaking making the computation of the Higgs mass compatible with the 126 GeV experimental value.
description: Proceedings of the "noncommutative geometry" parallel session of the conference "Conceptual and technical challenges for quantum gravity", Rome, 2014. To be published in Journal of Physics, conference series
SH2- and SH3-mediated Interactions between Focal Adhesion Kinase and Src
Creators: name: Thomas, Jeffrey W.
name: Ellis, Byron
name: Boerner, Renee J.
name: Knight, Wilson B.
name: White II, Gilbert C.
name: Schaller, Michael D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Intramolecular SH2 and SH3 interactions mediate enzymatic repression of the Src kinases. One mechanism of activation is disruption of these interactions by the formation of higher affinity SH2 and SH3 interactions with specific ligands. We show that a consensus Src SH3-binding site residing upstream of the Src SH2-binding site in FAK can function as a ligand for the Src SH3 domain. Surface plasmon resonance experiments indicate that a FAK peptide containing both the Src SH2- and SH3-binding sites exhibits increased affinity for Src. Furthermore, the presence of both sites in vitro more potently activates c-Src. A FAK mutant (FAKPro-2) with substitutions destroying the SH3-binding site shows reduced binding to Src in vivo. This mutation also reduces Src-dependent tyrosine phosphorylation on the mutant itself and downstream substrates, such as paxillin. These observations suggest that an SH3-mediated interaction between Src-like kinases and FAK may be important for complex formation and downstream signaling in vivo.
Stimulation of p38 Phosphorylation and Activity by Arachidonic Acid in HeLa Cells, HL60 Promyelocytic Leukemic Cells, and Human Neutrophils: EVIDENCE FOR CELL TYPE-SPECIFIC ACTIVATION OF MITOGEN-ACTIVATED PROTEIN KINASES
Creators: name: Costabile, Maurizio
name: Murray, Andrew W.
name: Rathjen, Deborah A.
name: Der, Channing J.
name: Ferrante, Antonio
name: Bilney, Andrea
name: Huang, Zhi H.
name: Hii, Charles S.T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Although it is well appreciated that arachidonic acid, a second messenger molecule that is released by ligand-stimulated phospholipase A2, stimulates a wide range of cell types, the mechanisms that mediate the actions of arachidonic acid are still poorly understood. We now report that arachidonic acid stimulated the appearance of dual-phosphorylated (active) p38 mitogen-activated protein kinase as detected by Western blotting in HeLa cells, HL60 cells, human neutrophils, and human umbilical vein endothelial cells but not Jurkat cells. An increase in p38 kinase activity caused by arachidonic acid was also observed. Further studies with neutrophils show that the stimulation of p38 dual phosphorylation by arachidonic acid was transient, peaking at 5 min, and was concentration-dependent. The effect of arachidonic acid was not affected by either nordihydroguaiaretic acid, an inhibitor of the 5-, 12-, and 15-lipoxygenases or by indomethacin, an inhibitor of cyclooxygenase. Arachidonic acid also stimulated the phosphorylation and/or activity of the extracellular signal-regulated protein kinase and of c-jun N-terminal kinase in a cell-type-specific manner. An examination of the mechanisms through which arachidonic acid stimulated the phosphorylation/activity of p38 and extracellular signal-regulated protein kinase in neutrophils revealed an involvement of protein kinase C. Thus, arachidonic acid stimulated the translocation of protein kinase C alpha, betaI, and betaII to a particulate fraction, and the effects of arachidonic acid on mitogen-activated protein kinase phosphorylation/activity were partially inhibited by GF109203X, an inhibitor of protein kinase C. This study is the first to demonstrate that a polyunsaturated fatty acid causes the dual phosphorylation and activation of p38.
The Effect of Extracellular Matrix Proteins on Porcine Smooth Muscle Cell Insulin-like Growth Factor (IGF) Binding Protein-5 Synthesis and Responsiveness to IGF-I
Creators: name: Duan, Cumming
name: Zheng, Bo
name: Clemmons, David R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: The aim of this study was to determine if cultured porcine vascular smooth muscle cells (pSMCs) that had been maintained on different extracellular matrix proteins had an alteration in their expression of insulin-like growth factor binding protein-5 (IGFBP-5) and their responsiveness to insulin-like growth factor-I (IGF-I). When pSMCs were plated on fibronectin, they synthesized 6.0 +/- 1.2-fold more IGFBP-5 than did cells maintained on laminin and type IV collagen. IGF-I increased IGFBP-5 gene expression 3-fold in the cells plated on fibronectin. The addition of an RGD peptide and echistatin to pSMC cultures that had been plated on fibronectin inhibited IGFBP-5 mRNA expression. The addition of an antibody against alpha2beta1 integrin partially reversed the inhibitory effects of laminin and type IV collagen on IGFBP-5 expression. Cells maintained on fibronectin had a 5.0 +/- 1.1-fold greater DNA synthesis response to IGF-I compared with those maintained on laminin/type IV collagen, and echistatin significantly inhibited the DNA synthesis response of the fibronectin-maintained cells to IGF-I. The anti-alpha2beta1 antibody partially reversed the inhibitory effect of laminin and type IV collagen on IGF-I-stimulated DNA synthesis. The addition of IGFBP-5 to cultures plated on laminin and type IV collagen significantly increased their response to IGF-I. Atherosclerotic plaques from pig aorta contained abundant fibronectin and had increased IGFBP-5 mRNA (4.5 +/- 1.5-fold) compared with tissue from the normal vessel wall that had a low fibronectin content. These results indicate that fibronectin, laminin, and type IV collagen have major effects on IGFBP-5 expression and on IGF-I-stimulated pSMC responses and that these effects are mediated by their respective integrins.
The Src Homology 2 and Phosphotyrosine Binding Domains of the ShcC Adaptor Protein Function as Inhibitors of Mitogenic Signaling by the Epidermal Growth Factor Receptor
Creators: name: Lambert, Que T.
name: O'Bryan, John P.
name: Der, Channing J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Upon ligand activation, the epidermal growth factor receptor (EGFR) becomes tyrosine-phosphorylated, thereby recruiting intracellular signaling proteins such as Shc. EGFR binding of Shc proteins results in their tyrosine phosphorylation and subsequent activation of the Ras and Erk pathways. Shc interaction with activated receptor tyrosine kinases is mediated by two distinct phosphotyrosine interaction domains, an NH2-terminal phosphotyrosine binding (PTB) domain and a COOH-terminal Src homology 2 (SH2) domain. The relative importance of these two domains for EGFR binding was examined by determining if expression of the isolated SH2 or PTB domain of ShcC would inhibit EGFR signaling. The SH2 domain potently inhibited numerous aspects of EGFR signaling including activation of Erk2 and the Elk-1 transcription factor as well as EGFR-dependent transformation. Furthermore, the SH2 domain inhibited focus formation by the Neu oncoprotein, another EGFR family member. Surprisingly, inhibition of the EGFR by the SH2 domain did not involve stable association with the receptor. In contrast, the PTB domain associated quite well with the receptor yet had little effect on EGFR signaling. Although the EGFR cytoplasmic tail contains consensus binding sites for the PTB and SH2 domains of ShcC, and both domains of ShcC interact with the receptor in vitro, the SH2 domain is more potent for inhibiting receptor function in vivo. However, inhibition is not due to stable association with the receptor, suggesting that the SH2 domain is binding to a heretofore unknown protein(s) necessary for proper EGFR function.
Determination of resonance locations in barred spiral galaxies using multiband photometry
Creators: name: Sierra, Amber D.
name: Seigar, Marc S.
name: Treuthardt, Patrick
name: Puerari, Ivanio
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: In this paper, we apply a method identified by Puerari & Dottori (1997) to find the corotation radii (CR) in spiral galaxies. We apply our method to 57 galaxies, 17 of which have already have their CR locations determined using other methods. The method we adopted entails taking Fourier transforms along radial cuts in the u, g, r, i, and z wavebands and comparing the phase angles as a function of radius between them. The radius at which the phase angles cross indicates the location of the corotation radius. We then calculated the relative bar pattern speed, $\mathcal{R}$, and classified the bar as "fast", where $\mathcal{R} < 1.4$, slow, where $\mathcal{R} \geq 1.4$, or intermediate, where the errors on $\mathcal{R}$ are consistent with the bar being "slow" or "fast". For the 17 galaxies that had their CR locations previously measured, we found that our results were consistent with the values of $\mathcal{R}$ obtained by the computer simulations of Rautiainen, Salo & Laurikainen (2008). For the larger sample, our results indicate that 34 out of 57 galaxies (~60%) have fast bars. We discuss these results in the context of its implications for dark matter concentrations in disk galaxies. We also discuss these results in the context of different models for spiral structure in disk galaxies.
description: Accepted for publication in MNRAS. Lanscape version of Table 2 can be found at http://d.umn.edu/~msseigar/papers/Table2.pdf ; Full paper will all figs can be found at http://d.umn.edu/~msseigar/papers/Amber1.pdf
Calculation of radiation reaction effect on orbital parameters in Kerr spacetime
Creators: name: Sago, Norichika
name: Fujita, Ryuichi
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We calculate the secular changes of the orbital parameters of a point particle orbiting a Kerr black hole, due to the gravitational radiation reaction. For this purpose, we use the post-Newtonian (PN) approximation in the first order black hole perturbation theory, with the expansion with respect to the orbital eccentricity. In this work, the calculation is done up to the fourth post-Newtonian (4PN) order and to the sixth order of the eccentricity, including the effect of the absorption of gravitational waves by the black hole. We confirm that, in the Kerr case, the effect of the absorption appears at the 2.5PN order beyond the leading order in the secular change of the particle's energy and may induce a superradiance, as known previously for circular orbits. In addition, we find that the superradiance may be suppressed when the orbital plane inclines with respect to the equatorial plane of the central black hole. We also investigate the accuracy of the 4PN formulae by comparing to numerical results. If we require that the relative errors in the 4PN formulae are less than $10^{-5}$, the parameter region to satisfy the condition will be $p\gtrsim 50$ for $e=0.1$, $p\gtrsim 80$ for $e=0.4$, and $p\gtrsim 120$ for $e=0.7$ almost irrespective of the inclination angle nor the spin of the black hole, where $p$ and $e$ are the semi-latus rectum and the eccentricity of the orbit. The region can further be extended using an exponential resummation method to $p\gtrsim 40$ for $e=0.1$, $p\gtrsim 60$ for $e=0.4$, and $p\gtrsim 100$ for $e=0.7$. Although we still need the higher order calculations of the PN approximation and the expansion with respect to the orbital eccentricity to apply for data analysis of gravitational waves, the results in this paper would be an important improvement from the previous work at the 2.5PN order, especially for large $p$ region.
description: 32 pages, 6 figures, minor corrections, minor modifications to match the published version in PTEP added, supplementary data files available at http://www2.yukawa.kyoto-u.ac.jp/~misao.sasaki/BHPC/
(1941) Adam Nisbet
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Prediction of interresidue contacts with DeepMetaPSICOV in CASP13.
Creators: name: Kandathil, Shaun M
name: Greener, Joe G
name: Jones, David T
Publisher: name: The Francis Crick Institute
Year: 2020
Subjects: Genetics & Genomics
Structural Biology & Biophysics
Computational & Systems Biology

description: In this article, we describe our efforts in contact prediction in the CASP13 experiment. We employed a new deep learning-based contact prediction tool, DeepMetaPSICOV (or DMP for short), together with new methods and data sources for alignment generation. DMP evolved from MetaPSICOV and DeepCov and combines the input feature sets used by these methods as input to a deep, fully convolutional residual neural network. We also improved our method for multiple sequence alignment generation and included metagenomic sequences in the search. We discuss successes and failures of our approach and identify areas where further improvements may be possible. DMP is freely available at: https://github.com/psipred/DeepMetaPSICOV. This article is protected by copyright. All rights reserved.
Details on the odour rating procedure from The scent of attractiveness: levels of reproductive hormones explain individual differences in women's body odour.
Creators: name: Lobmaier, Janek S.
name: Fischbacher, Urs
name: Wirthmüller, Urs
name: Knoch, Daria
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Individuals are thought to have their own distinctive body odour which reportedly plays an important role in mate choice. In the present study we investigated individual differences in body odours of women and examined whether some women generally smell more attractive than others or whether odour preferences are a matter of individual taste. We then explored whether levels of reproductive hormones explain women's body odour attractiveness, to test the idea that body odour attractiveness may act as a chemosensory marker of reproductive fitness. Fifty-seven men rated body odours of 28 healthy, naturally cycling women of reproductive age. We collected all odours at peak fertility to control for menstrual cycle effects on body odour attractiveness. Women's salivary oestradiol, progesterone, testosterone and cortisol levels were assessed at the time of odour collection to test whether hormone levels explain body odour attractiveness. We found that the men highly agreed on how attractive they found women's body odours. Interestingly, women's body odour attractiveness was predicted by their oestradiol and progesterone levels: the higher a woman's levels of oestradiol and the lower her levels of progesterone, the more attractive her body odour was rated. In showing that women's body odour attractiveness is explained by levels of female reproductive hormones, but not by levels of cortisol or testosterone, we provide evidence that body odour acts as a valid cue to potential fertility.
Transforming Potential of Dbl Family Proteins Correlates with Transcription from the Cyclin D1 Promoter but Not with Activation of Jun NH 2 -terminal Kinase, p38/Mpk2, Serum Response Factor, or c-Jun
Creators: name: Whitehead, Ian P.
name: Lee, Richard J.
name: Der, Channing J.
name: Pestell, Richard G.
name: Westwick, John K.
name: Symons, Marc
name: Lambert, Que T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: The dbl family of oncogenes encodes a large, structurally related, family of growth-regulatory molecules that possess guanine nucleotide exchange factor activity for specific members of the Rho family of Ras-related GTPases. We have evaluated matched sets of weakly and strongly transforming versions of five Dbl family proteins (Lfc, Lsc, Ect2, Dbl, and Dbs) to determine their ability to stimulate signaling pathways that are activated by Rho family proteins. We found that the transforming potential of this panel did not correlate directly with their ability to activate Jun NH2-terminal kinase, p38/Mpk2, serum response factor, or c-Jun. In contrast, transient stimulation of transcription from the cyclin D1 promoter provided a strong correlation with transforming potential, and we found constitutive up-regulation of cyclin D1 protein in Dbl family protein-transformed cells. In addition, we observed that at least two Dbl family members (Lfc and Ect2) induced changes in the actin cytoskeleton and exhibited nuclear signaling profiles that are consistent with a broader range of in vivo substrate utilization than is predicted from their in vitro exchange specificities. In summary, although Dbl family proteins exhibit signaling profiles that are consistent with their in vivo activation of Rho proteins, stimulation of cyclin D1 transcription is the only activity that correlates with transforming potential, thus suggesting that deregulated cell cycle progression may be important for Dbl family protein transformation.
The History of Warburg’s Library, 1886-1944
Creators: name: Saxl, Fritz
Publisher: name: La Rivista di Engramma
Year: 2023
Subjects: Fritz Saxl
Aby Warburg
Warburg Library
Ernst Gombrich

description: Fritz Saxl’s account of the Warburg Library, written in 1943-1944, was published for the first time by Ernst Gombrich as an Appendix to his Aby Warburg: An Intellectual Biography, in 1970. Saxl's text traces the history of the Library from its foundation in 1886 to 1943, when the future of the Institute, which had been moved to London in 1933, was uncertain.
‘Saccharomyces cerevisiae MSH2/6 Complex Interacts with Holliday Junctions and Facilitates Their Cleavage by Phage Resolution Enzymes
Creators: name: Griffith, Jack
name: Kolodner, Richard D.
name: Lee, Suman
name: Marsischky, Gerald T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: Genetic and biochemical studies have indicated that mismatch repair proteins can interact with recombination intermediates. In this study, gel shift assays and electron microscopic analysis were used to show that the Saccharomyces cerevisiae MSH2/6 complex binds to Holliday junctions and has an affinity and specificity for them that is at least as high as it has as for mispaired bases. Under equilibrium binding conditions, the MSH2/6 complex had a Kd of binding to Holliday junctions of 0.5 nM. The MSH2/6 complex enhanced the cleavage of Holliday junctions by T4 endonuclease VII and T7 endonuclease I. This is consistent with the view that the MSH2/6 complex can function in both mismatch repair and the resolution of recombination intermediates as predicted by genetic studies.
The incidence of magnetic fields in cool DZ white dwarfs
Creators: name: Hollands, Mark
name: Gaensicke, Boris
name: Koester, Detlev
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Little is known about the incidence of magnetic fields among the coolest white dwarfs. Their spectra usually do not exhibit any absorption lines as the bound-bound opacities of hydrogen and helium are vanishingly small. Probing these stars for the presence of magnetic fields is therefore extremely challenging. However, external pollution of a cool white dwarf by, e.g., planetary debris, leads to the appearance of metal lines in its spectral energy distribution. These lines provide a unique tool to identify and measure magnetism in the coolest and oldest white dwarfs in the Galaxy. We report the identification of 7 strongly metal polluted, cool (T_eff < 8000 K) white dwarfs with magnetic field strengths ranging from 1.9 to 9.6 MG. An analysis of our larger magnitude-limited sample of cool DZ yields a lower limit on the magnetic incidence of 13+/-4 percent, noticeably much higher than among hot DA white dwarfs.
description: 11 pages, 6 figures, 2 tables. Accepted for publication in MNRAS
Details on the odour collection from The scent of attractiveness: levels of reproductive hormones explain individual differences in women's body odour
Creators: name: Lobmaier, Janek S.
name: Fischbacher, Urs
name: Wirthmüller, Urs
name: Knoch, Daria
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Individuals are thought to have their own distinctive body odour which reportedly plays an important role in mate choice. In the present study we investigated individual differences in body odours of women and examined whether some women generally smell more attractive than others or whether odour preferences are a matter of individual taste. We then explored whether levels of reproductive hormones explain women's body odour attractiveness, to test the idea that body odour attractiveness may act as a chemosensory marker of reproductive fitness. Fifty-seven men rated body odours of 28 healthy, naturally cycling women of reproductive age. We collected all odours at peak fertility to control for menstrual cycle effects on body odour attractiveness. Women's salivary oestradiol, progesterone, testosterone and cortisol levels were assessed at the time of odour collection to test whether hormone levels explain body odour attractiveness. We found that the men highly agreed on how attractive they found women's body odours. Interestingly, women's body odour attractiveness was predicted by their oestradiol and progesterone levels: The higher a woman's levels of oestradiol and the lower her levels of progesterone, the more attractive her body odour was rated. In showing that women's body odour attractiveness is explained by levels of female reproductive hormones, but not by levels of cortisol or testosterone, we provide evidence that body odour acts as a valid cue to potential fertility.
A Non-farnesylated Ha-Ras Protein Can Be Palmitoylated and Trigger Potent Differentiation and Transformation
Creators: name: Baker, Tara L.
name: Booden, Michelle A.
name: Buss, Janice E.
name: Solski, Patricia A.
name: Punke, Steven G.
name: Channing, J. Der
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: Ha-Ras undergoes post-translational modifications (including attachment of farnesyl and palmitate) that culminate in localization of the protein to the plasma membrane. Because palmitate is not attached without prior farnesyl addition, the distinct contributions of the two lipid modifications to membrane attachment or biological activity have been difficult to examine. To test if palmitate is able to support these crucial functions on its own, novel C-terminal mutants of Ha-Ras were constructed, retaining the natural sites for palmitoylation, but replacing the C-terminal residue of the CAAX signal for prenylation with six lysines. Both the Ext61L and ExtWT proteins were modified in a dynamic fashion by palmitate, without being farnesylated; bound to membranes modestly (40% as well as native Ha-Ras); and retained appropriate GTP binding properties. Ext61L caused potent transformation of NIH 3T3 cells and, unexpectedly, an exaggerated differentiation of PC12 cells. Ext61L with the six lysines but lacking palmitates was inactive. Thus, farnesyl is not needed as a signal for palmitate attachment or removal, and a combination of transient palmitate modification and basic residues can support Ha-Ras membrane binding and two quite different biological functions. The roles of palmitate can therefore be independent of and distinct from those of farnesyl. Reciprocally, if membrane association can be sustained largely through palmitates, farnesyl is freed to interact with other proteins.
Results, when excluding the 36-year-old odour donor from the analyses. from The scent of attractiveness: levels of reproductive hormones explain individual differences in women's body odour
Creators: name: Lobmaier, Janek S.
name: Fischbacher, Urs
name: Wirthmüller, Urs
name: Knoch, Daria
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Individuals are thought to have their own distinctive body odour which reportedly plays an important role in mate choice. In the present study we investigated individual differences in body odours of women and examined whether some women generally smell more attractive than others or whether odour preferences are a matter of individual taste. We then explored whether levels of reproductive hormones explain women's body odour attractiveness, to test the idea that body odour attractiveness may act as a chemosensory marker of reproductive fitness. Fifty-seven men rated body odours of 28 healthy, naturally cycling women of reproductive age. We collected all odours at peak fertility to control for menstrual cycle effects on body odour attractiveness. Women's salivary oestradiol, progesterone, testosterone and cortisol levels were assessed at the time of odour collection to test whether hormone levels explain body odour attractiveness. We found that the men highly agreed on how attractive they found women's body odours. Interestingly, women's body odour attractiveness was predicted by their oestradiol and progesterone levels: The higher a woman's levels of oestradiol and the lower her levels of progesterone, the more attractive her body odour was rated. In showing that women's body odour attractiveness is explained by levels of female reproductive hormones, but not by levels of cortisol or testosterone, we provide evidence that body odour acts as a valid cue to potential fertility.
title: Налоги и налоговый менеджмент
title: Учебное пособие
titleType: Subtitle
Creators: name: Рудлицкая Н.В.
name:  Ануфриева А.В.
Publisher: name: Новосибирский государственный архитектурно-строительный университет (Сибстрин)
Year: 2015

description: В учебном пособии рассмотрены теоретические аспекты действующей системы налогообложения и налогового менеджмента, роль государства в формировании системы налогового менеджмента. Учебное пособие составлено в соответствии с требованиями федеральных стандартов образования и призвано помочь студентам в изучении дисциплин «Налоги и налогообложение» и «Налоговый менеджмент». Предназначено для студентов, обучающихся по направлениям подготовки 38.03.01 «Экономика», 38.03.02 «Менеджмент».
description: The tutorial discusses the theoretical aspects of the current system of taxation and tax management, the role of the state in the formation of the system of tax management. The manual drawn up in accordance with the requirements of Federal educational standards and is designed to help students in studying the courses "Taxes and taxation" and "Tax management". Designed for students enrolled in fields of study 38.03.01 "Economics", 38.03.02 "Management".
La storia della Biblioteca di Aby Warburg, 1886-1944
Creators: name: Fritz Saxl, Michela Maguolo
Publisher: name: La Rivista di Engramma
Year: 2023
Subjects: Fritz Saxl
Aby Warburg
Warburg Library
Ernst Gombrich

description: Fritz Saxl’s account of the Warburg Library, written in 1943-1944, was published for the first time by Ernst Gombrich as an Appendix to his Aby Warburg: An Intellectual Biography, in 1970. Saxl's text traces the history of the Library from its foundation in 1886 to 1943, when the future of the Institute, which had been moved to London in 1933, was uncertain.
A new butylphthalide from Ligusticum striatum DC.
Creators: name: Xie, Xue
name: Zhang, Hongda
name: Liu, Lina
name: Ni, Fuyong
name: Yu, Xiao
name: Zhong, Yan
name: Yan, Ming
name: Zhang, Chenfeng
name: Wang, Zhenzhong
name: Xu, Nan
name: Xiao, Wei
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology

description: One new butylphthalide ligusticumolide H (1), together with the known butylphthalides senkyunolide I (2), senkyunolide H (3), (3 R,3′S)-3′-hydroxy-3-butylphthalide (4), (3 R)-4-hydroxy-3-butylphthalide (5) and senkyunolide C (6) was isolated from the rhizome of Ligusticum striatum DC. Their structures were determined by extensive spectroscopic analyses including HR-ESI-MS, 1D and 2D NMR, and the absolute configuration of 1 was established by NMR and ECD calculations. Their effect on NO production in IL-1β-stimulated chondrocytes was also evaluated.
A Novel Element and a TEF-2-like Element Activate the Major Histocompatibility Complex Class II Transactivator in B-lymphocytes
Creators: name: Ting, Jenny P.Y.
name: Piskurich, Janet F.
name: Wright, Kenneth L.
name: Ghosh, Nilanjan
name: Wright, Gabriëla
name: Hassani, Kevin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: Major histocompatibility complex (MHC) class II molecules play a central role in immune responses, and transcription of this family of genes requires the MHC class II transactivator (CIITA). CIITA has four promoters, which are transcribed in a tissue-specific manner. CIITA promoter III is constitutively active in mature B-lymphocytes. This report now describes the minimal 319-base pair promoter region necessary for maximal transcriptional activity in B-lymphocytes. Ultraviolet light and dimethylsulfate in vivo genomic footprinting analyses reveal five occupied DNA sequence elements present in intact B-lymphocytes. Functional analysis of these elements using promoter deletions and site-specific mutations demonstrates that at least two of the sites occupied in vivo are critical for transcriptional activity. In vitro protein/DNA analysis suggests that one of the sites is a TEF-2-like element and the other is occupied by a novel transcription activator. In addition, nuclear factor-1 associates with the promoter both in vivo and in vitro. In myeloma cell lines, loss of CIITA transcription correlates with a completely unoccupied CIITA promoter III. These findings suggest that CIITA transcription in B-lymphocytes is activated through at least two strong promoter elements, while loss of expression in myeloma cells is mediated through changes in promoter assembly.
Absence of Spontaneous Peroxisome Proliferation in Enoyl-CoA Hydratase/l-3-Hydroxyacyl-CoA Dehydrogenase-deficient Mouse Liver: FURTHER SUPPORT FOR THE ROLE OF FATTY ACYL CoA OXIDASE IN PPARα LIGAND METABOLISM
Creators: name: Pan, Jie
name: Usuda, Nobuteru
name: Zhu, Yijun
name: Reddy, Janardan K.
name: Rao, M. Sambasiva
name: Maeda, Nobuyo
name: Hashimoto, Takashi
name: Qi, Chao
name: Yeldandi, Anjana V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: Peroxisomes contain a classical L-hydroxy-specific peroxisome proliferator-inducible beta-oxidation system and also a second noninducible D-hydroxy-specific beta-oxidation system. We previously generated mice lacking fatty acyl-CoA oxidase (AOX), the first enzyme of the L-hydroxy-specific classical beta-oxidation system; these AOX-/- mice exhibited sustained activation of peroxisome proliferator-activated receptor alpha (PPARalpha), resulting in profound spontaneous peroxisome proliferation in liver cells. These observations implied that AOX is responsible for the metabolic degradation of PPARalpha ligands. In this study, the function of enoyl-CoA hydratase/L-3-hydroxyacyl-CoA dehydrogenase (L-PBE), the second enzyme of this peroxisomal beta-oxidation system, was investigated by disrupting its gene. Mutant mice (L-PBE-/-) were viable and fertile and exhibited no detectable gross phenotypic defects. L-PBE-/- mice showed no hepatic steatosis and manifested no spontaneous peroxisome proliferation, unlike that encountered in livers of mice deficient in AOX. These results indicate that disruption of classical peroxisomal fatty acid beta-oxidation system distal to AOX step does not interfere with the inactivation of endogenous ligands of PPARalpha, further confirming that the AOX gene is indispensable for the physiological regulation of this receptor. The absence of appreciable changes in lipid metabolism also indicates that enoyl-CoAs, generated in the classical system in L-PBE-/- mice are diverted to D-hydroxy-specific system for metabolism by D-PBE. When challenged with a peroxisome proliferator, L-PBE-/- mice showed increases in the levels of hepatic mRNAs and proteins that are regulated by PPARalpha except for appreciable blunting of peroxisome proliferative response as compared with that observed in hepatocytes of wild type mice similarly treated. This blunting of peroxisome proliferative response is attributed to the absence of L-PBE protein in L-PBE-/- mouse liver, because all other proteins are induced essentially to the same extent in both wild type and L-PBE-/- mice.
Dual Space Graph Contrastive Learning
Creators: name: Yang, Haoran
name: Chen, Hongxu
name: Pan, Shirui
name: Li, Lin
name: Yu, Philip S.
name: Xu, Guandong
Publisher: name: arXiv
Year: 2022
Subjects: subject: Machine Learning (cs.LG)
subject: Social and Information Networks (cs.SI)
subject: FOS: Computer and information sciences

description: Unsupervised graph representation learning has emerged as a powerful tool to address real-world problems and achieves huge success in the graph learning domain. Graph contrastive learning is one of the unsupervised graph representation learning methods, which recently attracts attention from researchers and has achieved state-of-the-art performances on various tasks. The key to the success of graph contrastive learning is to construct proper contrasting pairs to acquire the underlying structural semantics of the graph. However, this key part is not fully explored currently, most of the ways generating contrasting pairs focus on augmenting or perturbating graph structures to obtain different views of the input graph. But such strategies could degrade the performances via adding noise into the graph, which may narrow down the field of the applications of graph contrastive learning. In this paper, we propose a novel graph contrastive learning method, namely \textbf{D}ual \textbf{S}pace \textbf{G}raph \textbf{C}ontrastive (DSGC) Learning, to conduct graph contrastive learning among views generated in different spaces including the hyperbolic space and the Euclidean space. Since both spaces have their own advantages to represent graph data in the embedding spaces, we hope to utilize graph contrastive learning to bridge the spaces and leverage advantages from both sides. The comparison experiment results show that DSGC achieves competitive or better performances among all the datasets. In addition, we conduct extensive experiments to analyze the impact of different graph encoders on DSGC, giving insights about how to better leverage the advantages of contrastive learning between different spaces.