cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Neural Stem Cell Therapy for Breast Cancer Brain Metastases
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Brain metastases are among the most feared complications in breast cancer.

 Despite today’s advances in early detection and treatment, nearly 30% of patients with advanced breast cancer are eventually diagnosed with brain lesions, making breast tumors the main source of metastatic brain disease in women. As a shielded ‘sanctuary site,’ the brain may harbor breast cancer cells that resist current treatments and can develop into metastases, long after chemo-, radiation- or immuno therapy have been applied. This situation can be controlled in the clinic only for a few weeks or months, often with severe side effects, which add to the trauma caused by the disease. Our project seeks to provide new hope as we try to inhibit breast cancer brain metastases through an innovative approach by harnessing neural stem cells (NSCs), the body’s own mechanism for healing and regeneration in the brain.

 This project is a continuation of an IDEA grant funded by the CBCRP in 2006. The data we have generated supported our original hypothesis that breast cancer brain metastases can be targeted with NSCs. We documented that such stem cells seek out cancerous areas in the brain and follow spreading breast cancer lesions within the

 brain tissue. The current grant explores where, when, how often and in what number NSCs need to be administered to an experimental “patient” to target breast cancer cells the brain and central nervous system. We have “armed” NSCs with cytosine deaminase, and showed in test tube experiments that the cells convert non-toxic 5-fluorocytosine into highly toxic 5-fluorouracil and thereby kill proliferating breast cancer cells very efficiently. We will now apply this treatment in whole animal models of breast cancer and measure if breast cancer brain lesions can be extinguished in immune deficient as well as immune competent settings. Finally, we are investigating if treatment with “armed” NSCs is safe, by following the NSCs in animal patients through non-invasive imaging and histology to determine the fate and distribution of the stem cells and their interaction with normal healthy tissues.

 Our previous results confirm the feasibility of this follow-up study to take us a step closer to a neural stem cell based therapy against breast cancer brain metastases. Employing the body’s own stem cells to target and deliver tumor-killing drugs is an exciting new application of stem cell biology, and this approach allows us to tackle one of the most difficult clinical settings for breast cancer.
Additional file 1: of Family context and individual situation of teens before, during and after pregnancy in Mexico City
Creators: name: Sámano, Reyna
name: Martínez-Rojano, Hugo
name: Robichaux, David
name: Rodríguez-Ventura, Ana
name: Sánchez-Jiménez, Bernarda
name: Hoyuela, Maria De La Luz
name: Godínez, Estela
name: Segovia, Selene
Publisher: name: Figshare
Year: 2017
Subjects: subject: Molecular Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Science Policy

description: Interview guide for pregnant teens. The interview guide provided information concerning the family context and the individual situation of the teens, and it was divided in three periods, before, during and after pregnancy. (DOC 61 kb)
HnRNP proteins in Rev mediated trafficking of HIV-1 mRNAs
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: In the past two decades the Food and Drug Administration approved 20 drugs for the treatment of HIV infection. Nevertheless, about half of the drug patients still experience treatment failure due to the development of viral resistance. There is an emerging class of drugs with over a dozen candidates under clinical trials that target host cell proteins and thus circumvent the problem of the evolution of resistant HIV strains. In an effort to find additional potential therapeutic targets we have recently identified 11 novel host cell proteins that interact with the HIV protein Rev and its RNA binding sequence in a systematic proteomic study. Our goal is to understand the impact these novel proteins have on HIV mRNA function. We propose to confirm our initially observed interaction of these proteins with Rev and its RNA binding sequence and to select a subset most pertinent for Rev function. The understanding how these proteins impact Rev function will enhance our knowledge about the molecular mechanism of HIV infection and might open up new avenues for therapeutic approaches.
Gonaporus mirabilis Zonstein & Wahis 2015
Creators: name: Gadallah, Neveen S.
name: Schmid-Egger, Christian
name: Brothers, Denis J.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Pompilidae
Gonaporus
Gonaporus mirabilis

description: Gonaporus mirabilis Zonstein & Wahis, 2015
Distribution in the Arabian Peninsula: United Arab Emirates (Zonstein & Wahis 2015).
Extralimital distribution: Pakistan (Zonstein & Wahis 2015).
description: Published as part of Gadallah, Neveen S., Schmid-Egger, Christian & Brothers, Denis J., 2020, Biodiversity of the aculeate wasps (Hymenoptera: Aculeata) of the Arabian Peninsula: Vespoidea, Pompilidae, pp. 153-173 in Zootaxa 4754 (1) on page 164, DOI: 10.11646/zootaxa.4754.1.16, http://zenodo.org/record/3719039
Additional file 1: of Durability of switch regimens based on rilpivirine or on integrase inhibitors, both in association with tenofovir and emtricitabine, in HIV-infected, virologically suppressed patients
Creators: name: Gianotti, Nicola
name: Poli, Andrea
name: Nozza, Silvia
name: Galli, Laura
name: Galizzi, Nadia
name: Ripa, Marco
name: Merli, Marco
name: Carbone, Alessia
name: Spagnuolo, Vincenzo
name: Lazzarin, Adriano
name: Castagna, Antonella
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: Specific PIs and NNRTIs ongoing at baseline. (DOCX 12Â kb)
Mustela nivalis Linnaeus 1766
Creators: name: Jo, Yeong-Seok
name: Baccus, John T.
name: Koprowski, John L.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Carnivora
Mustelidae
Mustela
Mustela nivalis

description: Mustela nivalis Linnaeus, 1766 —Least Weasel
Mustela nivalis Linnaeus, 1766 p.69; Type locality- Sweden; Ellerman & Morrison-Scott, 1951 p.256; Won, 1968 p.282; Han, 1994 p.46; Won & Smith, 1999; p.19; Oh, 2004a p.169.
M. nivalis mosanensis Mori, 1927 p.28; Type locality- Yeonam (near Musan), Korea; Kuroda, 1938 p.29; Ellerman & Morrison-Scott, 1951 p.258; Won, 1958 p.438; Won, 1967 p.113; Won, 1968 p.283.
M. pygmaea mosanensis: Kishida & Mori, 1931 p.380.
M. nivalis nivalis: Corbet, 1978 p.169; Yoon, 1992 p.102.
Range: Previously, mammalogists thought the least weasel in Korea had a distribution limited to the northeastern Korean Peninsula (Won 1968). However, although very rare, the least weasel is now found throughout most of the Korean Peninsula (NIBR 2012; Fig. 47).
Remarks: The least weasel is recognized in Korea as the Subspecies M. n. mosanensis (Won 1968). Corbet (1978) relegated most populations in Eurasia, including M. n. mosanensis, to a synonym of M. n. nivalis Linnaeus, 1766. Abramov and Baryshnikov (2000) identified 19 subspecies and confirmed one subspecies, M. n. mosanensis, in the Korean Peninsula, despite difference in coloration between northern and southern Korea. Specimens from northern Korea showed nivalis -coloration in which the winter coat turns completely white; however, southern population showed vulgaris -coloration with incomplete white coloration in winter coats (Choi & Choi 2007).
Conservation status: The North Korean government designated habitat of M. nivalis in the Mayang District, Musan County, Hamgyeongbuk Province as a Natural Monument in 1980. M. nivalis in South Korea are regarded as ‘Vulnerable’ (NIBR 2012) and in North Korea as ‘Rare’ (MAB National Committee of DPR Korea 2002).
description: Published as part of Jo, Yeong-Seok, Baccus, John T. & Koprowski, John L., 2018, Mammals of Korea: a review of their taxonomy, distribution and conservation status, pp. 1-216 in Zootaxa 4522 (1) on page 75, DOI: 10.11646/zootaxa.4522.1.1, http://zenodo.org/record/2610198
HIV-1 Cotranscriptional Splicing: Roles for Tat and NELF
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: This proposal is based on preliminary indications from our research that HIV-1 Tat expression in T cells may depend on the efficiency of Tat mRNA splicing, and that this may be different in TCR and TNF signaling cells. This idea is novel and supported by the observation that host cell TNF response genes are regulated in this manner, but as yet we lack preliminary data to support the hypothesis. The question is exceptionally well- suited to genome-wide ChIP-seq and GRO-seq analysis, which will allow much more quantitative comparison and assessment of the mechanism of HIV-1 nascent mRNA accumulation and how it compares with that of host cell TNF early- and late-response promoters. Bioinformatics could further extrapolate much information about how the sequence of HIV-1 core promoter compares to that of these host cell genes, and would further reveal whether NELF-regulated pausing is a gene-specific property that could be coupled with the need for slow elongation, to enhance incorporation of weak exons that might otherwise get skipped in the TNF signaling environment. However, at present we have no funding that would cover any ChIP-seq or GRO-seq analysis for HIV-1, nor have we previously had a reason to carry out such a study. Moreover, a full extrapolation of all of this data would extend well beyond the scope of this proposal. Nevertheless, carrying out the studies described in Aim 1, and in particular obtaining the ChIP-seq and GRO-seq data and finishing the initial assessment of whether splicing of Tat mRNAs are delayed in TNF compared to TCR-treated T cells would provide the most important information that would be needed to support an new RO-1 application to investigate this question.
Biological and chemical treatment of mono-, polycyclic, chloro, and nitro-aromatic mixtures in sediment and soil
Creators: name: Sheehan, Pamela L.
Publisher: name: No Publisher Supplied
Year: 2014

description: Hazardous waste composting is a demonstrated technology for many types of organic  contaminants. However, treatment outcome is often uncertain for hydrophobic compounds and  treatability studies are needed to predict performance. A composting pilot study was conducted  to determine the treatability of substituted aromatic hydrocarbons in two 15 m3 samples of tar-like  dye manufacturing waste sludge. Performance over a 49-day period was characterized for  mixtures of 1& aromatic compounds using first-order kinetics. Half-life was generally lower (8-  18 days) for chlorobenzene, xylenes, nitrobenzene, aniline, toluene, and ethylbenzene when  initially present at relatively high mass (above 10%). Nitrobenzene did not degrade in material  with a carbon to nitrogen ratio of 18:1 but did degrade in material with a ratio of 98:1. Although  50% to &5% of the contaminant mass was degraded, benzene, nitrobenzene, Nnitrodiphenylamine,  naphthalene, and benzo(a)anthracene concentrations were above regulatory  standards in finished compost. A fugacity analysis showed that compounds partitioned  significantly (ρ<0.05) to the organic fraction and non-aqueous phase liquid of the composting material. Application of Fenton reaction to improve treatment was more effective after bulking.  No significant (ρ<0.05) differences between biotreatment alone and biotreatment with pre and  post Fenton oxidation were observed. Alkaline hydrolysis using 5% w/w CaMg(OH)4 removed  nearly all of 25,000 mg/kg tetryl in soil. Picric acid and N-methylpicramide were tentatively  identified as treatment products. Biotransformation of the nitroaromatic compound RDX was  determined by comparing kinetic meta-data obtained from 42 studies. Degradation rates were  statistically faster for aerobic and anaerobic bacteria than for fungi. Results of this study show  that biodegradability, bioavailability, and kinetics are critical elements of a treatability analysis  and can identify the need for additional treatment processes. Processes can be integrated into  biotreatment using cost effective reagents that enhance compound removal. Additional research  is needed to define the chemical, biological, and physical interface of the integrated system to  improve process outcome.
Physiological Role of APOBEC3
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Human cells contain a protein called APOBEC3 that has the ability to interfere with the HIV replication. The protein destroys the genetic material, the DNA, of the virus, by chemically modifying it. Although APOBEC3 has the ability to destroy the virus, HIV produces a protein of its own called VIF that attaches to APOBEC3 to cause its destruction. The proposed project will investigate the properties of APOBEC3 by generating mice that are genetically unable to produce this protein. The mice will be used to study how the gene is turned on and off in the animals and will also be used to determine the function of APOBEC3 in the normal physiology of the mouse. These studies will be helpful for understanding how APOBEC3 functions in the body. This will be important as drugs are developed that work by preventing the HIV-induced destruction of APOBEC3. Such drugs could be potent inhibitors of HIV replication.
Theopropus Saussure 1898
Creators: name: Schwarz, Christian J.
name: Konopik, Oliver
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Mantodea
Hymenopodidae
Theopropus

description: Theopropus Saussure, 1898
Related to Hymenopus and Parymenopus, exhibiting extreme sexual dimorphism with dwarf males. First instar nymphs mimic reduviid bugs. Four species in SE Asia (Beier 1942, Yang & Zhang 1999, Ehrmann 2002). Arboricolous, restricted to forested habitats.
Theopropus borneensis Beier, 1942
Distribution. Borneo: Sarawak: Kuching (SMSM), Borneo Heights (CS in situ); Sabah: Sorinsim (AFUW), Poring Hot Springs (AFUW), Sandakan (Hebard 1920), Mt. Kinabalu (Beier 1942), Labuan Island (Hebard 1920); Kalimantan: Balikpapan (SMNK).
Fam. Iridopterygidae Giglio-Tos, 1915 1
description: Published as part of Schwarz, Christian J. & Konopik, Oliver, 2014, An annotated checklist of the praYing mantises (Mantodea) of Borneo, including the results of the 2008 scientific expedition to Lanjak Entimau Wildlife SanctuarY, Sarawak, pp. 130-168 in Zootaxa 3797 (1) on page 145, DOI: 10.11646/zootaxa.3797.1.12, http://zenodo.org/record/226038
Preserving, planning, and promoting the Lower East Side
Creators: name: Steinberg, Adam Zev
Publisher: name: No Publisher Supplied
Year: 2014

description: This single-case study explores a cultural nonprofit house museum’s proposal to create a historic district on New York’s Lower East Side, a low-income but gentrifying neighborhood, in 2006-200&. The museum’s proposal failed because the museum didn't engage potential neighborhood allies in true bottom-up planning, and because the City’s landmarks law made it impossible for the museum’s proposal to address the neighborhood’s foremost concern, which was loss of affordable housing. This study suggests that in the postindustrial city it's very difficult for low-income communities to use culture to lay claim to their neighborhoods. It also suggests that historic preservation laws allow higher-income neighborhoods to protect themselves from the creative destruction of redevelopment by becoming historic districts, while still allowing wealth-generating redevelopment to happen in lower-income neighborhoods. The study suggests further research is needed to see if there is a causal link between historic district designation and gentrification.
On my way
Creators: name: Song, Xueyuan
Publisher: name: No Publisher Supplied
Year: 2014

description: Nowadays people rely on their phones for much more than just communication. Phones are used for social media, as cameras, for emailing, and since more and more people begin to use smartphones, for navigation. Conventionally, the route recommendation given by GPS has been considered as the optimal route search problem only between two locations - origin and destination cite{manoj} and to make it more efficient, the map needs to be updated manually. However, in the real cases, several restrictions may need to be considered in the route recommendation. The restrictions could be several intermediate destinations which must be visited before reaching the final destination. For example, a user wants to visit places that belong to several general types, such as a bank and a gas station before arriving at working company, and then many choices may be available along the route to company, where only one place from each general type is to be chosen. Additionally, there is no good way on mobile phones, especially on the Android platform to figure out how to get from point A to point B while navigating through intermediate waypoints belonging to user' specified general type. Hence, this thesis tries to bring this issue to light, and provides a solution to the problem. The thesis make the following three contributions: first, proposing the algorithm help search nearby places and a strategy help get the optimal route through multiple intermediate waypoints. Second, an Android based application including the design and implementation which gives the optimal route recommendation by users' specified general types. Third, the result of the application is analyzed and discussed by using a JavaScript Application and R.
Mustela eversmanii Lesson 1827
Creators: name: Jo, Yeong-Seok
name: Baccus, John T.
name: Koprowski, John L.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Carnivora
Mustelidae
Mustela
Mustela eversmanii

description: Mustela eversmanii Lesson, 1827 —Steppe Polecat
Mustela eversmanni Lesson, 1827 p.144; Type locality- Orenburg Oblast, Russia; Kim et al., 2015 p.162.
Range: Only one individual was caught at Mt. Daeseon, Pyongyang in 1996 (Kim et al. 2015; Fig. 48). Since Pyongyang is a capital city of North Korea and far from general distribution of M. eversmanii, it’s uncertain whether the population is indigenous or feral. Additional collections in the geographic range of this semiarid habitat dweller are needed to determine the distribution on the Korean Peninsula.
Conservation status: North Korean red data book listed and assessed steppe polecat as data deficient in 2016.
description: Published as part of Jo, Yeong-Seok, Baccus, John T. & Koprowski, John L., 2018, Mammals of Korea: a review of their taxonomy, distribution and conservation status, pp. 1-216 in Zootaxa 4522 (1) on pages 75-76, DOI: 10.11646/zootaxa.4522.1.1, http://zenodo.org/record/2610198
Dietary intake patterns and Mediterranean diet adherence among Turkish adults
Creators: name: Spalding, Barbara M.
Publisher: name: No Publisher Supplied
Year: 2014

description: Much has been written about the Mediterranean Diet (MD), its beneficial health effects, and its many variations.  Turkey, located at the eastern end of the Mediterranean, has been described as having a MD, however there has been little to no previous research about its MD pattern.   This study examined dietary intake patterns, Mediterranean diet (MD) adherence and how MD adherence varied by city location in a geographically diverse sample of adults (aged 19 and older, n=3,001) living in urban centers in Turkey. The study was conducted as a secondary analysis of cross-sectional, nationally representative data collected in 2001-2002.  Dietary intake was assessed by a 60 item semi-quantitative food frequency questionnaire. The MedDietScore and the Mediterranean-Style Dietary Pattern Score (MSDPS) were used to evaluate MD adherence.  Variations in MD indices were examined using correlation, independent sample t-tests, ANOVA, ANCOVA and logistic regression. The dietary intake pattern was examined using factor analysis. The Turkish adults in this study followed a unique dietary pattern which included some characteristics of the MD but also had differences from the MD pattern. The Turkish dietary pattern identified in this study primarily consisted of bread, fruits and vegetables, yogurt and yogurt-based foods, some red meat, and black tea.  Participants reported low consumption of whole grains, legumes, potatoes, olive oil, wine and fish.  Factor analysis identified five dietary patterns including Turkish western (ice cream, red meat, desserts, sweetened beverages, nuts and seeds) and Turkish (yogurt, fruits, vegetables; bulgur and red meats – secondary loading). The MD indices varied by city after adjusting for age, gender, education, energy intake, and body mass index. Both MD indices had significant and positive correlations with education levels which is consistent with previous research from other countries.  This study makes a significant contribution to the understanding of the Turkish dietary intake patterns and provides evidence that the Turkish dietary pattern is unique.  Future research should further examine associations between the Turkish dietary intake patterns and factors such as individual and area level socioeconomic status, urban versus rural differences, and local food environment as well as related health outcomes.
Gonaporus omanicus Wolf 1990
Creators: name: Gadallah, Neveen S.
name: Schmid-Egger, Christian
name: Brothers, Denis J.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Pompilidae
Gonaporus
Gonaporus omanicus

description: Gonaporus omanicus Wolf, 1990
Distribution in the Arabian Peninsula: Oman (Wolf 1990c; Zonstein & Wahis 2015), United Arab Emirates (Schmid- Egger 2017).
Extralimital distribution: No records.
description: Published as part of Gadallah, Neveen S., Schmid-Egger, Christian & Brothers, Denis J., 2020, Biodiversity of the aculeate wasps (Hymenoptera: Aculeata) of the Arabian Peninsula: Vespoidea, Pompilidae, pp. 153-173 in Zootaxa 4754 (1) on page 164, DOI: 10.11646/zootaxa.4754.1.16, http://zenodo.org/record/3719039
What’s important to me
Creators: name: Stepney, Cesalie T.
Publisher: name: No Publisher Supplied
Year: 2014

description: There is a growing body of research examining the relationship between expressive writing and psychological stress and well-being. The current study sought to explore whether aspects of elementary students’ writing about their personal values could predict if students were considered more at-risk or more resilient.  This study used data from 1&6 5th grade students (Mean age = 10.95, 63.63% Female, &9.54% African American, 20.46% Hispanic) from a low-income, urban district in New Jersey who participated in a Laws of Life essay writing program as part of a larger school-based social-emotional learning intervention; these essays were analyzed using the Linguistic Inquiry and Word Count (LIWC) software, as well as qualitative coding by trained independent coders.  Students and their teachers rated students on a number of dimensions of resiliency and risk before and after essay writing (i.e., self-concept, social skills, internalizing, externalizing and hyperactivity behaviors), which were then used to predict at-risk and resilient cluster groups using a Two-Step Cluster Analysis procedure.  Discriminant Factor Analysis (DFA) results revealed that the percentage of LIWC-computed death-related words in the essays predicted at-risk group membership for Male students and Hispanic students.  The percentage of social process related words in the essays was also a significant predictor for Hispanic students, with more social process words predicting membership in the more resilient group.  These DFA results were replicated using post-intervention data, with two additions: the percentage of death-related words also predicted at-risk status for the African American subsample and family-related words predicted at-risk status for Male students.  In addition, individuals who wrote about a stressful life event, about one third of students, were more likely to be in the at-risk group post-intervention.  Overall, these results suggest that Laws of Life essay characteristics, particularly the percentage of death, social processes, and family-related words, can be predictive of at-risk or resiliency status in children from high-risk communities.  Further, the implications of students spontaneously mentioning stressful life events when writing about their personal values and identity are discussed.
Hippo signaling in regeneration and neoplastic tumors
Creators: name: Sun, Gongping
Publisher: name: No Publisher Supplied
Year: 2014

description: Hippo signaling controls organ size during development from Drosophila to humans. It limits tissue growth through regulation of cell proliferation and apoptosis. Deregulation of Hippo signaling leads to tissue overgrowth and tumor formation. An important characteristic of Hippo signaling is its connection to other pathways, through which Hippo signaling plays an indispensable role in diverse biological processes.      We found, in addition to regulating growth during development, Hippo signaling regulates growth during regeneration. The growth suppression effect of Hippo signaling is through inhibition of a transcriptional co-activator Yorkie (Yki). Yki can promote cell proliferation and suppress apoptosis. Using the Drosophila wing imaginal disc, a mono-layered epithelial tissue, as a model, we found Yki is activated in the wing discs in response to apoptosis induction. Yki remains active over the entire wing disc regeneration. Yki activation during regeneration requires c-Jun N-terminal kinase (JNK). JNK activation of Yki is independent of cell death, and through a Hippo pathway component, Jub (a fly Ajuba LIM domain protein). Both Yki and Jub are required for wing regeneration.  We also observed activation of Yki in the neoplastic tumors caused by disruption of epithelial apical-basal polarity. The growth of the neoplastic tumors is JNK-dependent. Like in regeneration, Yki activation in the neoplastic tumors also requires regulation of Jub by JNK. Reduction of Yki or Jub level suppresses tumor growth. Our work identified Jnk regulation of Hippo signaling as an important mechanism to drive the stress-responsive tissue growth, and established Jub and Yki as stress-responsive molecules.  JNK regulation of Yki is also conserved in mammalian cells. Using cultured epithelial cell lines, we found manipulation of JNK activity affects the activity of YAP (the mammalian homolog of Yki), like what we observed in flies. And JNK influences the binding of the mammalian Ajuba proteins to LATS (the mammalian homolog of Wts, a core kinase that suppresses Yki activity) through a phosphorylation-dependent mechanism. Ajuba proteins may serve as a hub connecting multiple pathways to the Hippo pathway as the binding between Ajuba proteins and LATS can also be regulated by other signaling pathways. The activity of Ajuba proteins may depend on their conformation.
Hapalopeza Stal 1877, s. str.
Creators: name: Schwarz, Christian J.
name: Konopik, Oliver
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Mantodea
Iridopterygidae
Hapalopeza

description: Hapalopeza Stål, 1877
Includes small, delicate-looking and rather colorful species distributed over most of S and SE Asia. Nymphs exhibit ant mimicry. Two subgenera are recognized (Hapalopeza s. str. and Spilomantis). One or two species of the nominate subgenus occur in Borneo. Arboricolous, also on high weeds and scrubs.
Hapalopeza (Hapalopeza) tigrina Westwood, 1889
Distribution. Malay Peninsula, Sumatra, Borneo, Labuan, Palawan (Hebard 1920, Werner 1926, Beier 1966, Ehrmann 2002).
Bornean records. Sarawak: Kuching (Werner 1926; SMSM), Mt. Matang (Werner 1926; SMSM), Mt. Mulu (CS in situ), Mt. Murud (Werner 1930), Mt. Dulit (Beier 1937, as H. nitens); Sabah: Poring Hot Springs (Helmkampf et al. 2007; SMNK, AFUW), Pulau Gaya (AFUW), Crocker Range (AFUW), Sorinsim (AFUW), Sandakan (Hebard 1920), Labuan Island (Hebard 1920), AFUW); Kalimantan: Long Petak (Werner 1933), Main (Beier 1958, as H. nitens), Tabang (Beier 1958, as H. nitens).
description: Published as part of Schwarz, Christian J. & Konopik, Oliver, 2014, An annotated checklist of the praYing mantises (Mantodea) of Borneo, including the results of the 2008 scientific expedition to Lanjak Entimau Wildlife SanctuarY, Sarawak, pp. 130-168 in Zootaxa 3797 (1) on page 145, DOI: 10.11646/zootaxa.3797.1.12, http://zenodo.org/record/226038
Enhancing network functionalities for emerging mobile networks through learning
Creators: name: Sun, Tingting
Publisher: name: No Publisher Supplied
Year: 2014

description: With rapid evolution of technology and growing use of wireless devices in our daily lives, mobile  network is becoming one of the most promising platforms for many brand new applications. Several  distinguished features make mobile network different from traditional computer networks, such as  high mobility and unpredictable mobility patterns. With the networks becoming increasingly diverse  and complex, it’s more and more difficult to know the properties of a network. Therefore,  the need for ”learning” important network characteristics in such a dynamic knowledge setting  becomes crucial. In this thesis, we show our research efforts to explore methods to learn important  network properties, and improve the following three aspects of mobile networks: data management,  load management, and identification services.    The data management issue is most critical when there is no central infrastructure available or  when the mobile-to-infrastructure communication bandwidth is limited. Since blindly uploading  every piece of sensor data to a remote server is inefficient, local data aggregation is required to  reduce the communication cost and improve efficiency. We propose the Geocache concept and  the Boomerang anchoring protocol to address this issue, and further introduce adaptive learning  methods to better deliver time-sensitive data.    Our efforts in load management are focused on adaptive load-balancing schemes for wireless  LANs where multiple access points are present. We propose a distributed access point selection  scheme by which nodes select an appropriate access point to associate with, based on each individual devices channel utilization. This approach effectively reduces unnecessary reassociations and improves upper layer performance such as throughput and packet delivery delay. We further enhance the association protocol by using reinforcement learning to dynamically schedule the probing of neighboring access points (APs). By learning from past experience, we ultimately bring down the probing overhead.    Lastly, we focus on the security aspect of the network by improving the identification process.  We examine the problem of identifying different association protocols based on probing patterns,  such as probing frequency and probing frame types. We apply learning methods to identify several  association protocols and propose an approach which combines k-means clustering and Gaussian  fitting to classify the association protocols.
On the normativity of epistemic rationality
Creators: name: Sylvan, Kurt Ludwig
Publisher: name: No Publisher Supplied
Year: 2014

description: Many epistemologists equate the rational and the justified.  Those who disagree have done little to explain the difference, leading their opponents to suspect that the distinction is an ad hoc one designed to block counterexamples.  The first aim of this dissertation--pursued in the first three chapters--is to improve this situation by providing a detailed, independently motivated account of the distinction.  The account is unusual in being inspired by no particular theoretical tradition in epistemology, but rather by ideas in the meta-ethical literature on reasons and rationality.  The account is also unusual in proposing that the distinction between rationality and justification can be derived from a reasons-based account of justification.   Historically, this is a striking claim.  In epistemology, reasons-based accounts of justification are standardly treated as paradigmatically internalist accounts, but this dissertation argues that we should believe the reverse: given the best views about reasons--again drawn from meta-ethics--we should expect reasons-based accounts of justification to be strongly externalist.     The first half of the dissertation might leave one wondering why rationality matters from the epistemic point of view.  The second aim of the dissertation is to answer this question.  The final two chapters argue (1) that we can only explain why rationality matters from the epistemic point of view if we reject the nearly universal assumption that all derivative epistemic value is instrumental value, and (2) that there are powerful reasons to reject this assumption, since it is the true origin of the so-called "swamping problem".  It is then argued that if we reject the instrumentalist assumption, we can get a truth-oriented account of epistemic value  that provides a unified explanation of how rationality, justification, and knowledge matter from the epistemic point of view.  This result is unprecedented: while some epistemologists find room for both internalist and externalist species of epistemic value, virtually all assume that these properties cannot have a common evaluative ground, and especially not a common truth-oriented one.  The concluding moral of the dissertation is that once we properly understand what it is to be truth-oriented, we see that this common assumption is mistaken.
Additional file 3: Figure S3. of The endonuclease EEPD1 mediates synthetic lethality in RAD52-depleted BRCA1 mutant breast cancer cells
Creators: name: Hromas, Robert
name: Hyun-Suk Kim
name: Sidhu, Gurjit
name: Williamson, Elizabeth
name: Jaiswal, Aruna
name: Totterdale, Taylor
name: Nole, Jocelyn
name: Suk-Hee Lee
name: Nickoloff, Jac
name: Kong, Kimi
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Marine Biology
subject: Cancer

description: EEPD1 depletion in BRCA1-depleted MCF7 breast cancer cells rescues synthetic lethality from RAD52 depletion. a–c MCF7 BRCA1-proficient cells were transiently transfected with control or RAD52 siRNA, with or without BRCA1 siRNA, for 48 h. Cells were plated for colony formation survival assays. a Western blot analysis. b Representation images of CFUs from each condition after 14 days. c Quantitative analysis of colony formation. d–f MCF7 BRCA1-proficient cells were transiently transfected with control, EEPD1 and/or RAD52 siRNA, with BRCA1 siRNA, for 48 h. Cells were plated for colony formation survival assays. d Western blot analysis. e Representation images of CFUs from each condition after 14 days. f Quantitative analysis of colony formation. Each experiment was performed ≥ 3 distinct times in triplicate. (PDF 459 kb)
Sceptuchus Hebard 1920
Creators: name: Schwarz, Christian J.
name: Konopik, Oliver
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Mantodea
Iridopterygidae
Sceptuchus

description: Sceptuchus Hebard, 1920
A poorly known genus that includes one Nepalese and one Malaysian species.
Sceptuchus simplex Hebard, 1920 §
Distribution. Malay Peninsula, Borneo (Hebard 1920, Ehrmann 2002, Svenson 2007). Bornean record. N Sabah (AFUW).
description: Published as part of Schwarz, Christian J. & Konopik, Oliver, 2014, An annotated checklist of the praYing mantises (Mantodea) of Borneo, including the results of the 2008 scientific expedition to Lanjak Entimau Wildlife SanctuarY, Sarawak, pp. 130-168 in Zootaxa 3797 (1) on page 145, DOI: 10.11646/zootaxa.3797.1.12, http://zenodo.org/record/226038
Mustela sibirica Pallas 1773
Creators: name: Jo, Yeong-Seok
name: Baccus, John T.
name: Koprowski, John L.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Carnivora
Mustelidae
Mustela
Mustela sibirica

description: Mustela sibirica Pallas, 1773 —Siberian Weasel
Mustela sibirica Pallas, 1773 p.701; Type locality- Siberian mountains (west Altai); Won,1968 p.285; Corbet, 1978 p.170; Han, 1994 p.46; Won & Smith, 1999 p.19; Oh, 2004a p.172.
Lutreola quelpartis Thomas, 1908b p.53; Type locality- Jeju Island.
M. manchurica Brass, 1911 p.490; Type locality- Manchuria.
Kolonocus sibiricus coreanus Domaniewski, 1926 p.55; Type locality- Seoul, Korea.
K. sibiricus katsurai: Kishida & Mori, 1931 p.380 (northern Korea; Nomen nudum).
K. sibiricus peninsulae Kishida and Mori, 1931 p.380 (most of Korean peninsula; Nomen nudum).
K. sibiricus quelpartis: Kishida & Mori, 1931 p.380 (Jeju Island); Corbet, 1978 p.170.
M. sibirica manchurica: Kuroda, 1938 p.30; Won, 1958 p.439; Won, 1967 p.114; Won,1968 p.285; Corbet, 1978 p.170; Yoon, 1992 p.102.
M. sibirica coreana: Kuroda, 1938 p.30; Tate, 1947 p.149; Ellerman & Morrison-Scott, 1951 p.262; Won, 1958 p.439; Won, 1967 p.116; Won, 1968 p.289; Yoon, 1992 p.194.
M. sibirica quelpartis: Kuroda, 1938 p.31; Ellerman & Morrison-Scott, 1951 p.261; Won, 1958 p.439; Won, 1967 p.121; Won, 1968 p.290; Yoon, 1992 p.105; Jo et al., 2012 p.252.
Range: The distribution of Mustela sibirica covers the Korean Peninsula from urban areas of Seoul to high mountains, where it is common (3 rd National Nature-Environmental Survey 2006–2013 unpublished electronic data; Fig. 49).
Remarks: Won and Smith (1999) described three subspecies, a northern population, M. s. manchurica, a southern population, M. s. coreana, and an isolated population on Jeju Island, M. s. quelpartis for the Siberian weasel in Korea. Mustela s. coreana was later synonymized with M. s. manchurica (Corbet 1978), which included: a peninsula subspecies, M. s. manchurica Brass, 1911; the subspecies on Jeju Island, M. s. quelpartis Thomas, 1908, Quelpart kolonok. Also, Abramov (2005) confirmed M. s. quelpartis as a valid subspecies by morphometric comparison with populations of the Korean Peninsula and M. itatsi in Japan. However, Koh et al. (2012c) found that the subspecies quelpartis was not genetically distinct from the subspecies of the Korean Peninsula; thus, they did not support the current classification based on pelage color variation.
Conservation status: Ulsan, Daejeon, and Gwangju Metropolitan governments designated M. sibirica as a Provincially Protected Species.
description: Published as part of Jo, Yeong-Seok, Baccus, John T. & Koprowski, John L., 2018, Mammals of Korea: a review of their taxonomy, distribution and conservation status, pp. 1-216 in Zootaxa 4522 (1) on pages 76-79, DOI: 10.11646/zootaxa.4522.1.1, http://zenodo.org/record/2610198
Gonaporus simulator Wahis & Zonstein in Zonstein & Wahis 2015
Creators: name: Gadallah, Neveen S.
name: Schmid-Egger, Christian
name: Brothers, Denis J.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Pompilidae
Gonaporus
Gonaporus simulator

description: Gonaporus simulator Wahis & Zonstein in Zonstein & Wahis, 2015
Distribution in the Arabian Peninsula: Saudi Arabia, United Arab Emirates (Zonstein & Wahis 2015).
Extralimital distribution: Egypt, Israel, Mauritania (Zonstein & Wahis 2015).
description: Published as part of Gadallah, Neveen S., Schmid-Egger, Christian & Brothers, Denis J., 2020, Biodiversity of the aculeate wasps (Hymenoptera: Aculeata) of the Arabian Peninsula: Vespoidea, Pompilidae, pp. 153-173 in Zootaxa 4754 (1) on page 164, DOI: 10.11646/zootaxa.4754.1.16, http://zenodo.org/record/3719039
On the location of the paper "The Lidov-Kozai oscillation and Hugo von Zeipel"
Creators: name: Ito, Takashi
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 510107
subject: Planetary science (excl. solar system and planetary geology)

description: In the spring of 2022, the publisher of this monograph (Terrapub) went bankrupt and the official website disappeared. Since there is no printed version of this monograph series, there is currently no way to access any of our paper (Takashi Ito and Katsuhito Ohtsuka, "The Lidov-Kozai oscillation and Hugo von Zeipel", Monogr. Environ. Earth Planets, 7 (1), 1-113, 2019) published in this monograph. Naturally, the DOI for our paper is also not linked anywhere. We have no idea if this publisher's website will be restored or when the DOI information will be corrected.As a temporary solution to this problem, we have placed the PDF files of the main text and its supplementary material of this paper at the following sites so that interested readers can access our paper.On ResearchGate:main text and supplementary informationOn the author's homepage:A whole archive of the publisher's webpagePDF main textPDF supplementary informationPreprint on arXiv:astro-ph > arXiv:1911.03984A poster presented at EPSC 2020 (id. EPSC2020-269)is attached in this material.
Mustela altaica Pallas 1811
Creators: name: Jo, Yeong-Seok
name: Baccus, John T.
name: Koprowski, John L.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Carnivora
Mustelidae
Mustela
Mustela altaica

description: Mustela altaica Pallas, 1811 —Mountain Weasel
Mustela altaica Pallas, 1811 p.98; Type locality- Altai mountain; Heptner et al., 1967 p.1042; Nowak, 1999 p.705; Han, 1994 p.46; Won & Smith, 1999 p.19.
Kolonocus alpinus raddei: Ognev, 1931 p.734 (p. 554 in English translated edition).
M. altaica raddei: Corbet, 1978 p.169 (probably Manchuria and Korea).
Range: Despite no collection of specimens from Korea, it is highly conceivable that M. altaica inhabits at least extreme northeastern Korea based on collections of the species at the border between China, Russia, and North Korea (Won & Smith 1999). The most likely location for the presence of M. altaica in Korea would be Hamgyeongbuk Province, nearby to collection sites of the species in China and Russia (Fig. 50). Although the IUCN distribution map of M. altaica includes the Korean Peninsula, Abramov et al. (2008) regarded that the inclusion of North Korea within the geographic range as needing confirmation.
Remarks: Since Ognev (1928) suggested the occurrence of M. altaica in Korea, this species gained a place on the list of mammals of Korea. The quasi absence of mammalian faunal surveys in North Korea together with the confusion of M. altaica with M. sibirica, have hampered the assessment of the distribution of the species in Korea.
Conservation status: Not considered at risk by Korean institutions.
description: Published as part of Jo, Yeong-Seok, Baccus, John T. & Koprowski, John L., 2018, Mammals of Korea: a review of their taxonomy, distribution and conservation status, pp. 1-216 in Zootaxa 4522 (1) on page 79, DOI: 10.11646/zootaxa.4522.1.1, http://zenodo.org/record/2610198
Epsomantis Giglio-Tos 1915
Creators: name: Schwarz, Christian J.
name: Konopik, Oliver
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Mantodea
Iridopterygidae
Epsomantis

description: Epsomantis Giglio-Tos, 1915
Monotypic genus. Its classification among the mainly afrotropical Nilomantinae is probably erroneous. Arboricolous.
Epsomantis tortricoides (De Haan, 1842) §
Mantis (Mantis) tortricoides De Haan, 1842
Distribution. Java, Borneo (De Haan 1842, Beier 1931a).
Bornean records. Sabah: Sandakan (Hebard 1920), Bettotan (Beier 1931a), N Sabah (AFUW).
Subfam. Tropidomantinae Giglio-Tos, 1915 1
description: Published as part of Schwarz, Christian J. & Konopik, Oliver, 2014, An annotated checklist of the praYing mantises (Mantodea) of Borneo, including the results of the 2008 scientific expedition to Lanjak Entimau Wildlife SanctuarY, Sarawak, pp. 130-168 in Zootaxa 3797 (1) on page 146, DOI: 10.11646/zootaxa.3797.1.12, http://zenodo.org/record/226038
Gonaporus spinosissimus Wahis & Zonstein in Zonstein & Wahis 2015
Creators: name: Gadallah, Neveen S.
name: Schmid-Egger, Christian
name: Brothers, Denis J.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Pompilidae
Gonaporus
Gonaporus spinosissimus

description: Gonaporus spinosissimus Wahis & Zonstein in Zonstein & Wahis, 2015
Distribution in the Arabian Peninsula: Oman (Zonstein & Wahis 2015).
Extralimital distribution: No records.
description: Published as part of Gadallah, Neveen S., Schmid-Egger, Christian & Brothers, Denis J., 2020, Biodiversity of the aculeate wasps (Hymenoptera: Aculeata) of the Arabian Peninsula: Vespoidea, Pompilidae, pp. 153-173 in Zootaxa 4754 (1) on page 164, DOI: 10.11646/zootaxa.4754.1.16, http://zenodo.org/record/3719039