cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Network conduciveness with application to the graph-coloring and independent-set optimization transitions
Creators: name: Barbosa, Valmir C.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Data Structures and Algorithms (cs.DS)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: We introduce the notion of a network's conduciveness, a probabilistically interpretable measure of how the network's structure allows it to be conducive to roaming agents, in certain conditions, from one portion of the network to another. We exemplify its use through an application to the two problems in combinatorial optimization that, given an undirected graph, ask that its so-called chromatic and independence numbers be found. Though NP-hard, when solved on sequences of expanding random graphs there appear marked transitions at which optimal solutions can be obtained substantially more easily than right before them. We demonstrate that these phenomena can be understood by resorting to the network that represents the solution space of the problems for each graph and examining its conduciveness between the non-optimal solutions and the optimal ones. At the said transitions, this network becomes strikingly more conducive in the direction of the optimal solutions than it was just before them, while at the same time becoming less conducive in the opposite direction. We believe that, besides becoming useful also in other areas in which network theory has a role to play, network conduciveness may become instrumental in helping clarify further issues related to NP-hardness that remain poorly understood.
A democratic theory of hope : collective agency in uncertain times
Creators: name: Lacelle-Webster, Antonin
Publisher: name: University of British Columbia
Year: 2023

description: Democratic institutions and practices ideally empower people to talk, organize, deliberate, and act with others to imagine, decide, and move toward collective futures. They navigate the uncertainty of collective action through the hopes that connect people with both one another and future publics. Hope enables democracies to organize aspirations. It captures the creative potentialities of democracy by forming and actualizing political agency while, in turn, enabling polities to move toward desired futures. In this dissertation, I provide a democratic theory of hope which identifies the kinds of hope that underwrite democracy and the political conditions that organize and empower democratic hope. Narratives of hope are a fixture of democratic moments of high political mobilization, yet just as often, they are dismissed as naïve, disempowering, or distracting. This apparent ambiguity is, in part, owing to a lack of analysis within democratic theory that would enable us to distinguish the various natures, kinds, and political functions of hope. As hope emerges from the uncertainty of political life, how political processes mediate the temporal and spatial intervals within which hope unfolds shapes its articulation. I juxtapose Harvey Milk’s “The Hope Speech” with received theories of hope to uncover the in-betweenness of hoping with others, best conceptualized by Hannah Arendt’s phenomenological approach to politics. Taking my lead from Arendt and her notions of natality, action, and promises, I conceptualize democratic hope as a collective good structured by the open-ended, discursive, and collective features of politics. Democratic hope involves an openness that justifies deliberative and disruptive political practices, which play complementary roles in defining and challenging possible futures. I adopt a problem-based approach to democracy to organize this collective work and experience of hope, and then situate it in relation to how democracies pursue their normatively desired functions. A democratic theory of hope points toward practical institutional reforms and innovations, particularly those that enable the open-ended, discursive, and collective work that supports, empowers, and actualizes hope. I illustrate this point with the example of climate assemblies, as their integration into democratic systems organizes hope by navigating the constraints and possibilities that structure the climate emergency.
RR Lyrae Pulsation Theory
Creators: name: Marconi, Marcella
Publisher: name: arXiv
Year: 2009
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: RR Lyrae stars play an important role as distance indicators and stellar population tracers. In this context the construction of accurate pulsation models is crucial to understand the observed properties and to constrain the intrinsic stellar parameters of these pulsators. The physical mechanism driving pulsation in RR Lyrae stars has been known since the middle of the 20th century and many efforts have been performed during the last few decades in the construction of more and more refined pulsation models. In particular, nonlinear pulsation models including a nonlocal time-dependent treatment of convection, such as the ones originally developed in Los Alamos in the seventies, allow us to reproduce all the relevant observables of radial pulsation and to establish accurate relations and methods to constrain the intrinsic stellar properties and the distance of these variables. The most recent results on RR Lyrae pulsation obtained through these kinds of models will be presented and a few still debated problems will be discussed.
description: 12 pages, 11 figures, invited review at the Santa Fe, NM, conference -- Stellar Pulsation: Challenges for Theory and Observation; May 31-June 5, 2009
He-Mg compounds and helium-driven nonmetal transition in metallic magnesium
Creators: name: Huang, Y. S.
name: Song, H. X.
name: Hao, Q. D.
name: Pan, X. L.
name: Wang, D.
name: Wang, H.
name: Wang, Y. F.
name: Sun, Y.
name: Geng, Hua Y.
Publisher: name: arXiv
Year: 2025
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Other Condensed Matter (cond-mat.other)
subject: Chemical Physics (physics.chem-ph)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: The polymorphism and mechanism of helium compounds is crucial for understanding the physical and chemical nature of He-bearing materials under pressures. Here, we predict two new types of He-bearing compounds, MgHe and MgnHe (n = 6, 8, 10, 15, 18), being formed above 750 GPa by unbiased ab initio structure search. An unexpected bandgap is opened up in MgHe at as low as around 200 GPa. This is the first case of noble gas driven metal-nonmetal transition in all elements. The same mechanism is demonstrated also being applicable to other metallic elements, and making beryllium transform into a non-metallic state, a triumph that is impossible otherwise. Furthermore, the stability of the simple cubic phase of Mg (Mg-sc) is greatly enhanced by mixing with He, which lowers the critical pressure of pure Mg-sc from about 1.1 TPa down to 750 GPa to form ordered substitutional alloying phase of MgnHe on a simple cubic lattice of Mg. This is the first report on Mg-based noble gas substitutional alloy, in sharp contrast to the conventional wisdom that He preferring interstitial sites. The observed striking influences of He demonstrate the rich physics and chemistry of He-bearing compounds under ultra-high pressures.
description: 22 pages, 5 figures, with supporting materials
Social Work's Intervention into Rural Women's Empowerment in Australia and China
Creators: name: ZHAOEN PAN
Publisher: name: Monash University
Year: 2019
Subjects: subject: 160799 Social Work not elsewhere classified
subject: FOS: Sociology

description: This thesis focuses on the practices that social workers adopt to empower rural women in Australia and China. Countries differ in terms of their political, economic, social, and cultural structures. These differences generate divergent knowledge, value systems, and power networks in the local social work profession, and this is demonstrated in complex social work practices. Research exploring social workers’ empowerment practices with rural women in Australia and China identifies discourses of professionalization, indigenization, internationalization, and feminist practices. The research demonstrates that there can be mutual understanding and an exchange of knowledge between Australia and China.
Search for Outbursts in the Narrow 511-keV Line from Compact Sources Based on INTEGRAL Data
Creators: name: Tsygankov, S.
name: Churazov, E.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present the results of a systematic search for outbursts in the narrow positron annihilation line on various time scales (5x10^4 - 10^6 s) based on the SPI/INTEGRAL data obtained from 2003 to 2008. We show that no outbursts were detected with a statistical significance higher than ~6 sigma for any of the time scales considered over the entire period of observations. We also show that, given the large number of independent trials, all of the observed spikes could be associated with purely statistical flux fluctuations and, in part, with a small systematic prediction error of the telescope's instrumental background. Based on the exposure achieved in ~6 yr of INTEGRAL operation, we provide conservative upper limits on the rate of outbursts with a given duration and flux in different parts of the sky.
description: 16 pages, 8 figures. To be published in Astronomy Letters, 2010, Vol. 36, No 4, p. 237
Language, loss and time: 2009 Black Saturday bushfires in Victoria
Creators: name: MAE AMBER PROUDLEY
Publisher: name: Monash University
Year: 2019
Subjects: subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: Environmental Humanities
subject: 160403 Social and Cultural Geography
subject: FOS: Social and economic geography
subject: 160499 Human Geography not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: 160512 Social Policy
subject: FOS: Political science
subject: Anthropology
subject: 170113 Social and Community Psychology
subject: FOS: Psychology
subject: History

description: This narrative inquiry has grappled with loss and grief in the wake of the 2009 Black Saturday bushfires in Victoria. Primary material obtained from men and women of the Latrobe Valley revealed the fragilities of home and the complexities of both negative and positive emotions associated with re-establishing intimate domestic spaces. This research has explored the complicated ‘emotional work’ and the sometimes difficult decision-making triggered by sudden and profound loss. It suggests that failing to acknowledge or validate the less apparent losses can confuse or prolong the processing of grief that fire-affected people contend with in the aftermath of bushfire.
On the spectrum of fluctuations of a liquid surface: From the molecular scale to the macroscopic scale
Creators: name: Blokhuis, Edgar M.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We show that to account for the full spectrum of surface fluctuations from low scattering vector qd << 1 (classical capillary wave theory) to high qd > 1 (bulk-like fluctuations), one must take account of the interface's bending rigidity at intermediate scattering vector qd = 1, where d is the molecular diameter. A molecular model is presented to describe the bending correction to the capillary wave model for short-ranged and long-ranged interactions between molecules. We find that the bending rigidity is negative when the Gibbs equimolar surface is used to define the location of the fluctuating interface and that on approach to the critical point it vanishes proportionally to the interfacial tension. Both features are in agreement with Monte Carlo simulations of a phase-separated colloid-polymer system.
description: 18 pages, 11 figures, accepted for publication in The Journal of Chemical Physics
PHOTOCATALYTIC REACTIONS FOR ENERGY CONVERSION
Creators: name: RIBONI, FRANCESCA
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: General upward trends in fossil fuel consumption and CO2 emissions, along with the accepted belief that global chemistry substantially influences climate, require that scientific research provides efficient remedies and/or alternatives to the present scenario. Photocatalysis is often proposed as one of the most promising technique to achieve these purposes. This PhD thesis is mainly focused on the investigation of TiO2-based systems for the photocatalytic oxidation of formic acid in aqueous suspension, as well as for H2 production by methanol photo steam reforming in the gas phase. Two different approaches were adopted to minimize the drawbacks usually characterizing TiO2 photocatalysts: i) TiO2-WO3 mixed oxide photocatalysts were prepared with the aim of reducing the recombination rate of photopromoted electron/hole pairs. The superior photocatalytic performance of the mixed oxide system was mainly attributed to the positive effect induced by W in efficiently trapping the photopromoted electron from the conduction band of TiO2, ensuring extended charge carriers separation. Even better results were obtained upon the surface modification with Pt nanoparticles which, by virtue of the metal high work function, further enhanced e-/h+ separation. ii) surface modification of TiO2 with Au nanoparticles, possessing a Localized Surface Plasmon Resonance (LSPR) at ? = 530 nm was proved to be an efficient way to promote TiO2 photoactivity under visible light irradiation. By selecting three titania samples (i.e., a stoichiometric, nearly non defective TiO2, a N-doped TiO2 and a oxygen vacancy-rich TiO2), evidence of two different plasmonic photoactivity mechanisms was provided, with the so-called hot electron transfer promoting plasmonic photoactivity in the stoichiometric TiO2 and Plasmon Resonance Energy Transfer accounting for the observed plasmonic visible light photoactivity of doped samples. Being the abatement of CO2 through (photo)electrochemical reduction very challenging (E0(CO2/CO2-* = -2.14 V)), an alternative way has been studied: pyridinyl radicals (1-PyH*), photogenerated by irradiating a pyridine (Py) solution, were found to efficiently react with CO2 yielding a carbamic species (HPy-1-COOH), triggered by a stepwise mechanism where electron transfer from 1-PyH* precedes proton transfer. Formate (HCOO-) was also obtained, demonstrating that photoexcited pyridine does catalyze the 2e?reduction of CO2. Finally, Fenton oxidation of gaseous isoprene on the surface of aqueous Fe2+ droplets, yielding carboxylic acids, polyols and carbonyl compounds, detected in situ through ElectroSpray Ionization Mass Spectrometry, accounted for alternative routes for the conversion of organic gases into secondary organic aerosol, occurring under tropospheric conditions, and may be incorporated into present atmospheric chemistry models.
Hydrodynamical simulations of Galactic fountains II: evolution of multiple fountains
Creators: name: Melioli, Claudio
name: Brighenti, Fabrizio
name: D'Ercole, Annibale
name: Pino, E. M. de Gouveia Dal
Publisher: name: arXiv
Year: 2009
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Using 3D hydrodynamical simulations, we studied in detail the fountain flow and its dependence with several factors, such as the Galactic rotation, the distance to the Galactic center, and the presence of a hot gaseous halo. We have considered the observed size-frequency distribution of young stellar clusters within the Galaxy in order to appropriately fuel the multiple fountains in our simulations. The present work confirms the localized nature of the fountain flows: the freshly ejected metals tend to fall back close to the same Galactocentric region where they are delivered. Therefore, the fountains do not change significantly the radial profile of the disk chemical abundance. The multiple fountains simulations also allowed to consistently calculate the feedback of the star formation on the halo gas. Finally, we have also considered the possibility of mass infall from the intergalactic medium and its interaction with the clouds that are formed by the fountains. Though our simulations are not suitable to reproduce the slow rotational pattern that is typically observed in the halos around the disk galaxies, they indicate that the presence of an external gas infall may help to slow down the rotation of the gas in the clouds and thus the amount of angular momentum that they transfer to the coronal gas, as previously suggested in the literature.
description: 19 pages, 18 figures, accepted for publication in MNRAS
Outcomes Following Abiraterone versus Enzalutamide for Prostate Cancer: A Scoping Review Protocol
Creators: name: Shah, Yash
name: Shaver, Amy
name: Lu-Yao, Grace
Publisher: name: figshare
Year: 2022
Subjects: subject: 110312 Nephrology and Urology
subject: FOS: Clinical medicine
subject: 111204 Cancer Therapy (excl. Chemotherapy and Radiation Therapy)

description: Scoping review protocol to determine the differential toxicities and outcomes of abiraterone acetate and enzalutamide in prostate cancer patients.
NOVEL FUNCTIONS OF THE SNARE PROTEIN SNAP29IN MEMBRANE TRAFFICKING AND CELL DIVISION
Creators: name: MORELLI, ELENA
Publisher: name: Universit� degli Studi di Milano
Year: 2015

description: Vesicular trafficking within cells is an important process for tissue development and homeostasis. A key step of vesicular trafficking is the fusion between two membranes, a process in which SNARE (Soluble NSF Attachment Protein Receptors) proteins play a fundamental role. SNAP29 (SyNaptosomal Associated Proteins 29) is a ubiquitous SNARE, regulating membrane fusion in different trafficking compartments and in different contexts in non dividing cells. We isolated a loss of function mutant in usnp, the gene encoding the Drosophila homolog of the human protein SNAP29 (Snap29 hereafter), that, when made homozygous in developing epithelial organs, disrupts epithelial architecture. In vivo, we find that Snap29 interacts with multiple SNARE proteins, localizes to a number of trafficking organelles, and is required for proper Golgi Apparatus morphology. In addition, we show that Snap29 is required for fusion of autophagosomes with lysosomes together with Syx17 and Vamp7, and that lack of Snap29 results in excess secretion, suggesting that Snap29 might act negatively in regulation of vesicle fusion at the plasma membrane. Interestingly, at the onset of mitosis, when trafficking compartments re-shape to allow the formation of the mitotic spindle, Snap29 is found at the outer KT in Drosophila S2 cells and localizes at spindle microtubules and centrosomes in mammalian cells. Depletion of Snap29 in Drosophila and mammalian cells leads to spindle assembly defects, associated to pro-metaphase delay in mammalian cells, and to the formation of daughter cells containing mininuclei. Mechanistically, lack of SNAP29 correlates with absence at KT of ZWINT-1 and ZWILCH, a component of RZZ complex, and with weak KTs-MTs attachments. In addition, we find that SPINDLY, the adaptor for recruitment to KTs of dynein/dynactin and MAD1, a component of the Spindle Assembly Checkpoint machinery, fail to be removed from KTs at the end of metaphase in SNAP29 depleted mammalian cells forced to reassemble the spindle after treatment with microtubules depolymerization drug. Finally, we show that cell division is impaired in Snap29 mutant tissues in vivo, that autophagy defects are not the cause of the altered epithelial tissues architecture in Snap29 mutants and that the trafficking and cell division function of Snap29 are molecularly distinct. All together our findings support a role of Snap29 at key steps of membrane trafficking and in cell division. Our study contribute to shed light on the pathogenesis of CEDNIK, a human congenital syndrome caused by SNAP29 inactivation. In addition to this, we propose that the function of SNAP29 in cell division might be evolutionarly related to that of complexes tethering MTs to vesicular organelles in interphase. We surmise that such function could be potentially relevant to development of aneuploidy in tumor-like masses.
Social work - client relationship practice: exploring social worker perspectives
Creators: name: WENDY ELIZABETH ROLLINS
Publisher: name: Monash University
Year: 2019
Subjects: subject: 160799 Social Work not elsewhere classified
subject: FOS: Sociology

description: This thesis explores, using qualitative methodology, the significance of social worker – client relationships for achieving client outcomes in the field of child and family welfare. The study found that social worker – client relationships are critical for achieving outcomes. It is a distinct practice method, informed by relational views about ‘the self’, human development and healing. The social worker, as Relationship Building Agent, is heavily focused on client engagement and building the Relationship Workspace. These findings are represented in the approach Social Work Relationship Praxis. Implications for social work practice, education and research include recommended elevation of relational perspectives.
Gymnodactylus arnouxii A. Dum.
Creators: name: Müller, F
Publisher: name: Zenodo
Year: 1885
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Squamata
Sauria
Phyllodactylidae
Gymnodactylus

description: Gymnodactylus arnouxii A. Dum., ang.
S. -O. Guinea v. F M.
description: Published as part of Müller, F, 1885, Vierter Nachtrag zum Katalogder herpetologischen Sammlung des Basler Museums, pp. 668-717 in Verhandlungen der Naturforschenden Gesellschaft in Basel. 7 (3) on page 710, DOI: 10.5962/bhl.part.2388, http://zenodo.org/record/15183591
MOLECULAR CHARACTERIZATION OF THE ROLE OF CBL PROTEINS IN EGFR ENDOCYTOSIS
Creators: name: PASCOLUTTI, ROBERTA
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: c-Cbl is the major E3 ligase involved in ubiquitination of Epidermal Growth Factor Receptor (EGFR). Ubiquitination by c-Cbl plays a critical role in EGFR endocytosis by targeting receptors to lysosomal degradation. Its involvement at early internalization steps is still debated, also due to the fact that multiple internalization pathways were described. Indeed, EGFR ubiquitination is required for non-clathrin mediated endocytosis (NCE), while it is not essential for clathrin endocytosis (CME). However, c-Cbl might still play a crucial function also in CME since, in addition to its role as an E3 ligase, it works also as an adaptor, by recruiting several proteins involved in the early phases of this process. Importantly, c-Cbl has been found mutated in different disorders, from myeloproliferative disease to Noonan syndrome and non-small cell lung cancer (NSCLC). Most of these mutations are located within the Ring finger domain and in the regulatory linker region, and are therefore predicted to affect E3 ligase activity. However, some mutations map outside this region, suggesting that they might impinge on the adaptor function without altering E3 ligase activity. None of these mutations was characterized in detail at the mechanistic level. In order to draw a more precise molecular picture of c-Cbl activity in EGFR ubiquitination and endocytosis, we investigated the effects of different set of cancer-relevant mutations, combining two distinct approaches: 1) RNA interference-based functional assays and 2) in vitro ubiquitination assays. 1) First, we characterized the effect of the knockdown (KD) of c-Cbl (and its family members) on EGFR ubiquitination and endocytosis in two different cell systems, murine fibroblast and HeLa cells. From our data, we confirmed that c-Cbl is essential for NCE, by ubiquitinating the EGFR; however, it also plays a role in CME. Importantly, reconstitution experiments with RING finger mutants demonstrated that c-Cbl E3 ligase activity is also required for CME. Since EGFR ubiquitination is not essential for CME, we hypothesize that this activity is exerted not directly on the receptor but on endocytic adaptors. In agreement, Eps15 monoubiquitination is impaired upon c-Cbl KD. 2) We were able to reconstitute the EGFR ubiquitination reaction in vitro, and now we can use this tool to study the molecular details of c-Cbl catalysis. Moreover, in order to dissect c-Cbl adaptor function vs E3 ligase activity, we plan to investigate the phenotype of c-Cbl mutations that map outside the E3 ligase domain in EGFR internalization and ubiquitination, exploiting both in vivo analyses (through reconstitution experiments in cell lines) and in vitro ubiquitination assay.
The visible-light-driven photocatalytic reduction of Cr6+ using BiVO4: Assessing the effect of Au deposition and the reaction parameters
Creators: name: Durán-Álvarez, Juan C.
name: Drisya, K.T.
name: García-Tablas, Rodrigo
name: Lartundo-Rojas, Luis
name: Solís-López, Myriam
name: Zanella, Rodolfo
name: Subramaniam, Velumani
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: In this work, fern leaf-like BiVO4 was used to photocatalytically reduce Cr6+ in water. Nanosized BiVO4 displayed bandgap energy and specific surface area of 2.49 eV and 5.65 m2 g-1, respectively. Metallic Au nanoparticles were deposited on the BiVO4 to increase the photocatalytic performance. To optimize the reaction conditions, the sacrificial agents methanol, ethanol, formic acid, dimethyl sulfoxide, and KI were tested, while different catalyst dosages and Au loadings were assessed. The best sacrificial agent was formic acid, which was used at an optimal concentration of 0.01 mol L-1. The complete removal of Cr6+ was attained after 90 min of visible light irradiation using a catalyst dosage of 1.5 g L-1. Depositing metallic Au nanoparticles barely improved the photocatalytic performance, thus unmodified BiVO4 was used to remove Cr6+ in tap water. The matrix effect slowed the photocatalytic process, and the complete removal of Cr6+ was achieved in 120 minutes. Cr3+ and Cr6+ species were precipitated on the catalyst surface at the end of the photocatalytic process; still, BiVO4 displayed high stability after three reaction cycles.
Additional file 2 of Novel susceptibility loci identified in a genome-wide association study of type 2 diabetes complications in population of Latvia
Creators: name: Ustinova, Monta
name: Peculis, Raitis
name: Rescenko, Raimonds
name: Rovite, Vita
name: Zaharenko, Linda
name: Elbere, Ilze
name: Silamikele, Laila
name: Konrade, Ilze
name: Sokolovska, Jelizaveta
name: Pirags, Valdis
name: Klovins, Janis
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 2: Quantile-quantile plots for GWAS of T2DM complications.
Nutritional enrichment of fruit peel wastes using lipid accumulating Aurantiochytrium strain as feed for aquaculture in North-East Region of India
Creators: name: Saikia, Diganta Kumar
name: Chikkaputtaiah, Channakeshavaiah
name: Velmurugan, Natarajan
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Hematology
subject: Plant Biology

description: Utilization of fruit peel wastes to grow thraustochytrids for nutritional enrichment of wastes will lower environmental and economic costs associated with feed stock specific for aquaculture industries. In this study, high-carbohydrate content agricultural wastes such as orange, pineapple, banana, and mausambi fruit peels were enriched with essential fatty acids producing thraustochytrids Aurantiochytrium sp. ATCC276. Characterizations of fruit peels revealed the presence of high carbohydrate content (9 to 16%), and reducing sugars essential for the growth of thraustochytrids. Optimization for lipid production of Aurantiochytrium sp. ATCC276 was carried out using response surface methodology (RSM) in combination with different concentrations of fruit peels in solid-state fermentation (SSF) conditions. Fruit peels composed SSF experiments were designed using central composite design. Aurantiochytrium sp. ATCC276 cells were efficiently utilized the sugar components of fruit peels for their growth and lipid accumulation. Different SSF composites made of fruit peels were significantly enriched with fatty acids of Aurantiochytrium sp. ATCC276 cells. Culturing Aurantiochytrium sp. ATCC276 cells with these waste materials demonstrated distinct responses toward lipid accumulation at different compositions. The optimized SSF composite consists of 9.91 g 100 mL-1 orange, 5 g 100 mL-1 mausambi, 4.12 g 100 mL-1 pineapple, and 8.01 g 100 mL-1 banana peels and was enriched with 8.37% of Aurantiochytrium sp. ATCC276-derived lipids. This study expands the benefits and bioprocessing potential of essential fatty acids producing Aurantiochytrium sp. ATCC276 along with fruit peel wastes which in fact a frontier in circular bioeconomy and valorising waste for usage.
HOW DO SCHOOL EXPERIENCES RELATE TO OFFENDING BEHAVIOUR FROM THE PERSPECTIVE OF YOUNG MALE OFFENDERS?
Creators: name: CATHERINE EMILY POWELL
Publisher: name: Monash University
Year: 2019
Subjects: subject: Education
subject: Personality, Social and Criminal Psychology
subject: 160799 Social Work not elsewhere classified
subject: FOS: Sociology

description: The lived school experiences of young males aged 16 to 21, and how these experiences may have influenced a trajectory into pro-criminal behaviour, is the subject of this qualitative study. Thematic analysis of 20 semi-structured interviews with participants from African, Maori Pacific Island and Australian descent reveal several key domains of risk within the school environment. Focus groups with adult representatives from schools and youth services were conducted following the interviews to comment on, and reinforce, the findings. The aim of the study was to capture the thoughts and feelings of these young males with the firm belief that their expert opinions will add to the knowledge base.
Supplementary Figure 8. from Hidden diversity of double-stranded DNA phages in symbiotic Rhizobium species
Creators: name: Santamaría, Rosa I.
name: Bustos, Patricia
name: Van Cauwenberghe, Jannick
name: González, Víctor
Publisher: name: The Royal Society
Year: 2021
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 60301 Animal Systematics and Taxonomy
subject: 60310 Plant Systematics and Taxonomy
subject: 60408 Genomics

description: VIPTree phylogeny. To further support the VCs, we used the VIPTree program, which is based on the similarity in proteins by tBlastx (e-value 10–2; identity 30%; amino acid length 30) converted to distance in a Neighbor-Joining Tree. The concentric circles indicate: inner, host NCBI taxonomy; middle, phages ICTV taxonomy; outer, VCs. Color code for the distinct taxonomic ranks and VC are similar to the inset in Figure 3.
APPEARANCE OF OSSIFICATION CENTERS OF THE LIMBS AND SKELETAL DEVELOPMENT IN NEWBORN TOY-DOG BREEDS: RADIOGRAPHIC, MORPHOMETRIC AND HISTOLOGICAL ANALYSIS
Creators: name: MOIOLI, MELANIA
Publisher: name: Universit� degli Studi di Milano
Year: 2014

description: The study aims to find out the chronological appearance of the ossification centers of appendicular skeleton of newborn toy-breed dogs during the first month of life and to correlate the data obtained with morphometric measures of the skeleton by radiological and anatomical approach. Data obtained were implemented with bone mineral density (BMD) analysis of the long bones and histological and histochemical analysis of limbs bone sections, to evaluate and quantify the trends of the ossification process and the architectural changes of ossification centers. The study was carried out in 37 newborn toy-breed dogs <28 days old, spontaneously died for unrelated reasons with this study, divided into 4 groups on the basis of age (first week, second week, third week and fourth week). The forelimbs and the hind limbs have been evaluated by radiological and histological analysis. Long bones, cranial and body measurements, both radiological and anatomical, were taken and the BMD of radius and ulna and of os femoris was calculated. The results have been correlated through statistical analysis and compared with standard charts proposed by Literature in order to assess significant differences with medium and large breed dogs. The appearance of most of the ossification centers reflects the timing of ossification of medium and large breed dogs, however the behavior of some ossification centers changes and therefore might be considered typical of toy-dog breeds. Femoral length could be taken into consideration as a parameter to assess the developmental rate and the age of toy-breed dogs during the growing period, particularly in the first 4 weeks of age. Increasing BMD is highly correlated with increasing long bones length and seems to confirm the space-time relationship between BMD in canine newborn skeleton and in long bones growth. The radiological, histological and bone mineral density analysis and the correlations between long-bones length, skull diameters, age and body mass, might be currently appropriate to determine the skeletal age in newborn toy-dog breeds.
PROCESSO PENALE E PROCEDIMENTI DISCIPLINARI
Creators: name: ZOERLE, PIETRO
Publisher: name: Universit� degli Studi di Milano
Year: 2016

description: Ogni volta che un fatto commesso da un lavoratore costituisca contemporaneamente un illecito penale e un illecito disciplinare si profilano interferenze tra il procedimento penale e il procedimento disciplinare. Nel settore del lavoro privato i rapporti tra i due procedimenti sono ispirati al principio di reciproca autonomia, con la conseguenza che il datore di lavoro esercita il potere disciplinare indipendentemente dall?azione penale. Vi sono, tuttavia, delle ipotesi in cui la giurisprudenza e la contrattazione collettiva hanno individuato dei meccanismi di raccordo tra i diversi procedimenti. Viene a delinearsi una disciplina disomogenea, che nell?applicazione pratica risente di soluzioni calibrate in base alla singola fattispecie concreta. Peraltro, nel caso di impugnazione della sanzione disciplinare davanti al giudice civile, � necessario considerare gli effetti del giudicato che la sentenza penale pu� esprimere in quel giudizio ai sensi dell?art. 654 c.p.p. Diversamente, nei settori del pubblico impiego e delle libere professioni ha mantenuto per molto tempo un ruolo centrale l?istituto della pregiudizialit� penale che impone la sospensione del procedimento disciplinare quando per lo stesso fatto il p.m. ha esercitato l?azione penale. Il procedimento disciplinare rimane sospeso fino agli esiti del giudizio penale e la sentenza esprime efficacia di giudicato ai sensi dell?art. 653 c.p.p. Una serie di recenti riforme, tuttavia, ha in parte abbandonato la sospensione necessaria del procedimento disciplinare, al fine di rendere pi� celere la risposta disciplinare a gravi illeciti compiuti dai pubblici dipendenti e dai liberi professionisti. Gli interventi del legislatore non riguardano generalmente tutti i pubblici impiegati e i liberi professionisti, ma soltanto alcune particolari categorie, e ci� determina ulteriori asimmetrie tra i diversi settori. La presente tesi di dottorato cerca di ricostruire la complessa rete dei rapporti tra processo penale e procedimenti disciplinari in materia di lavoro, sottolineando le incongruenze di un sistema che, da un lato, sponsorizza l?autonomia fra i diversi settori dell?ordinamento e, dall?altro lato, fatica ad abbandonare l?idea del necessario coordinamento tra gli esiti di procedimenti di natura diversa aventi per oggetto il medesimo fatto.
SUBJECTIVITIES EN TRANSIT. (IM)MOBILITIES OF ASYLUM SEEKERS ACROSS AND BEYOND THE EUROPEAN BORDERS
Creators: name: FONTANARI, ELENA
Publisher: name: Universit� degli Studi di Milano
Year: 2016

description: Migration is a central phenomenon of the global age, which Western societies often treat as a temporary and emergency case that needs to be managed and controlled. This thesis explores the tension between the EU internal borders and the crossing-border mobilities of migrant subjects that attempt to build autonomous lives in Europe. Drawn on 20 months (October 2013 ? August 2015) of fieldwork in Milan and Berlin using multi-sited ethnography, this work investigates the everyday experiences of a group of ?temporary refugees? who have obtained a temporary humanitarian protection in Italy after escaping the Libya war in 2011. Because of unemployment and homelessness, a part of them undertook secondary movements towards northern European countries to find better life conditions, although they were not allowed under the European laws. Some of these temporary refugees joined the Oranienplatz protests in Berlin and claimed their rights to freely work and move through Europe. Here, I focus on the everyday life of my research protagonists in Milan and Berlin and the recurring cross-border movements back and forth between these places. The contradictory attempt of institutions and bureaucracies to control and host them in their ambivalent image as victim and internal enemy entails a lengthened temporariness and a hypermobility in the migrant subjects biographies. In my research Europe emerges as a space of negotiation practices where the internal border are constantly re-defined by the tensions and frictions of different actors. The permanent negotiation of the borders occurs in the battleground of the everyday lives and affects the biographies of the migrant subjects on the move. I find that the temporal rather than the spatial dimension is crucial in the understanding of migrant subjects experiences in the EU border regime. My research protagonists internalize the lengthened transit condition ? which is juridical, spatio-temporal and existential ? becoming thus subjectivities en transit. This suggests that migration should be understood as a process of becoming, where the interrelation of control mechanisms and autonomous social practices of migrant subjects challenges and re-defines the borders of Europe. I argue that subjectivities en transit emerge that criss-cross the European territory, attempting to autonomously build their lives moving between the social and juridical constrains. They open up interstices of autonomy, although the precariousness of their everyday shapes their lives as fragmented.
TRANSCRIPTOME ANALYSIS OF TUMOR INFILTRATING T REGULATORY CELLS UNVEILS SPECIFIC CODING AND NON CODING GENE SIGNATURE
Creators: name: POLITANO, CLAUDIA LUCIA
Publisher: name: Universit� degli Studi di Milano
Year: 2019

description: CD4+ Regulatory T cells (Treg cells) are a specialized subpopulation of T cells that act to suppress immune response, thereby maintaining homeostasis and self-tolerance. These cells play a critical role in preventing autoimmunity infections, and cancer. Treg cells can infiltrate tumor tissues where they suppress anti-tumor immune responses, contributing to the development of an immunosuppressive tumor microenvironment thus promoting immune evasion and cancer progression. Tumor infiltrating Treg cells can display function heterogeneity, depending on both the tumor type and the inflammatory milieu, therefore molecular characterization of Treg cells is crucial to understand how these cells can be modulated in the tumor to unleash effective anti-tumor T cell responses. To this aim, we investigated the transcriptional blueprints of Treg cells both in tumors and in the peripheral blood of healthy donors to define both coding and non-coding transcripts that best define the identity of these cells and might therefore represent novel prognostic markers or therapeutic targets. We performed a transcriptome analysis of both CD4+ Treg cells and effector cells (Th1 and Th17) infiltrating two of the most frequent types of human cancer defining the molecular signatures of tumor-infiltrating Treg cells in these two cancer types. We found tumor-infiltrating Treg cells were highly suppressive, upregulated several immune-checkpoints, and expressed on the cell surfaces specific signature molecules such as interleukin-1 receptor 2 (IL1R2), programmed death (PD)-1 Ligand1, PD-1 Ligand2, and CCR8 chemokine enriched in tumor infiltrating Treg cells compared to both the peripheral blood of patients and healthy donors. Given the high specificity of long non-coding RNA compared to coding sequences, we also performed bioinformatic analysis to assess the expression of known and novel non-coding transcripts. With this analysis we identified specific Treg cell non-coding transcript in proximity of CTLA4 locus. Since lncRNAs are by now considered as key regulatory elements in immune cell differentiation and maintenance of their identity, we characterized the identified lncRNAs in Treg cells in healthy donors, defining their epigenetic organization, expression level, localization and whether they contributed to the established Treg cell suppressive activity. All these findings unveiled another layer of the complexity of Treg cells biology and warrants for more detailed functional studies that can fully explain the pathways and the cellular networks that are affected by the identified coding and non-coding transcripts.
XORIJIY TILLARNI O'QITISH METODIKASIDA ZAMONAVIY USULLAR
Creators: name: G'aniyeva, Muborak
name: Ergasheva, Durdonaxon
Publisher: name: Zenodo
Year: 2023

description: Ushbu maqola xorijiy tillarni o'qitish metodikasining zamonaviy usullari haqida qisqacha ma'lumot beradi. U til ta'limida qo'llaniladigan turli yondashuvlar, uslublar va tamoyillarni o'rganadi. Abstrakt vazifaga asoslangan til o'rganish, kompyuter yordamida til o'rganish, teskari o'rganish, kontent va tilni integratsiyalashgan o'rganish (CLIL) va o'rganishni o'yinlashtirishning ahamiyatini ta'kidlaydi. Shuningdek, u xorijiy tillarni o'qitish samaradorligini oshirishda materiallarni ishlab chiqish, shaxsni aniqlash, vakolatlarni kengaytirish va ikkinchi til talaffuzini tadqiq qilish muhimligini ta'kidlaydi.
Supplementary Figure 4. from Hidden diversity of double-stranded DNA phages in symbiotic Rhizobium species
Creators: name: Santamaría, Rosa I.
name: Bustos, Patricia
name: Van Cauwenberghe, Jannick
name: González, Víctor
Publisher: name: The Royal Society
Year: 2021
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 60301 Animal Systematics and Taxonomy
subject: 60310 Plant Systematics and Taxonomy
subject: 60408 Genomics

description: In silico analysis of the distribution of phages and prophages onto Rhizobium hosts phylogeny. Phages and prophages grouped into VCs were localised into the phylogenetic tree of 654 Rhizobium genomes done according the description in Material and Methods. The figures (a) to (c) corresponded to phages and prophages in VCs as were classified in the network of Fig. 1. (a) 15 VC_phages; (b) Six VC_composite with members associated with different species; (c) 30 VC_prophage with members associated with single species and various species. Phages in Sinorhizobium and Agrobacterium within five (VCs) were not considered in the analysis (see Supp. Table 4). Red lines indicate phage clusters within the same species; blue lines are phages and prophages of the same VC distributed in two or three species. With the purpose of simplifying the number of crossing-lines, we divided the Rhizobium species (Supp. Table 2) in three broad sections (second circle) according to the colour code in the inset.
Additional file 1 of Impact of baseline clinical and radiological features on outcome of chronic rhinosinusitis in granulomatosis with polyangiitis
Creators: name: Holme, Sigrun Skaar
name: Kilian, Karin
name: Eggesbø, Heidi B.
name: Moen, Jon Magnus
name: Molberg, Øyvind
Publisher: name: figshare
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: Hematology

description: Additional file 1 Longitudinal relationship between sinus mucosal disease measured by Lund-Mackay score (LM-score) and osteitis measured by Global Osteitis Scoring Scale (GOSS) in selected patients of the three osteitis trajectory groups. (A) Distribution of baseline LM-score. (B) Subplots showing GOSS and LM-scores for each CT in each of the selected patients of the three osteitis trajectory groups. A vertical coloured line indicates the start of treatment with cyclophosphamide or rituximab in each patient.
THE IMPACT OF PHOSPHOROUS CONTROL IN CHRONIC KIDNEY DISEASE (CKD) PATIENTS
Creators: name: BELLASI, ANTONIO
Publisher: name: Universit� degli Studi di Milano
Year: 2015

description: Chronic Kidney Disease Mineral Bone (CKD-MBD) disorder is associated with a significant morbidity and mortality. In vitro and animal models suggest that phosphorous, calcium, parathyroid hormone and vitamin D abnormalities mediate the cardiovascular and bone diseases that characterize CKD-MBD and increase the risk of death. Currently, mineral abnormalities are corrected through phosphorous restriction, phosphate binders, calcimimetics and vitamin D administration. Nonetheless, data in humans that support the use of these compounds are still scanty, mainly based on observational studies. Thus, a considerable number of doubts and questions still challenge clinicians dealing with CKD patients and mineral metabolism imbalances. We herein critically review clinical evidence that support the use of different drugs in CKD-MBD and present recent data on the clinical relevance of phsophorous control in CKD patients.