cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Idiopathic pulmonary fibrosis: from monocyte and macrophage inflammation to a novel, non-invasive measurement of pulmonary density
Creators: name: Patrucco, Filippo
Publisher: name: Università del Piemonte Orientale
Year: 2022
Subjects: subject: Idiopathic Pulmonary Fibrosis
subject: Idiopathic Pulmonary Fibrosis

description: The anti-fibrotic drug nintedanib (NTD) has been approved for the management of Idiopathic Pulmonary Fibrosis (IPF), a rare progressive interstitial lung disease. Monocytes/macrophages and alveolar macrophages have been demonstrated to contribute to the wound healing process, promoting inflammation and collagen deposition. Aim: We intend to evaluate the effects of NTD on phenotype and responsiveness of monocytes/macrophages isolated from IPF patients before (TO) and after 3 months of treatment (T1) with the drug. In this thesis the results obtained from patients at TO will be showed. Samples from healthy volunteers and from patients will be challenged in vitro with NTD. Methods: Monocytes were isolated from peripheral blood and differentiated into M1 and M2 macrophages; cell viability, superoxide anion production and surface markers expression were evaluated. Results: we included 10 IPF patients and 5 healthy volunteers. For in vitro experiments, we used increasing concentrations of NTD up to the highest of 15nM. In monocytes from both healthy volunteers and patients NTD reduced the basal production of superoxide anion and at 15nM the effect was similar in both populations. After NTD treatment we observed a reduction of non classical monocytes percentage, with a relative reduction of classical monocytes. NTD did not significantly affect the basal 02- production in M1 neither in M2, but it reduced in a dose dependent manner the PMA-induced burst in both macrophage populations. Among surface markers' expression, we observed a reduction of CD206 in M2 macrophages of IPF subjects after NTD stimulation. Conclusions: Our results could build the basis to verify if in IPF patients monocyte production of oxidative stress would influence macrophages polarization, and to support the antifibrotic effects of NTB also by the reduction of CD206 profibrotic marker expression in M2 cells.
O-silylierter Milchaldehyd - Diastereomere Derivate
Creators: name: Tanner, U.
name: Eibler, E.
name: Burgemeister, T.
name: Wiegrebe, Wolfgang
Publisher: name: Universität Regensburg
Year: 1992
Subjects: subject: 540 Chemie

description: The title compound 2 was obtained either by reduction of O-silylated methyl lactate (1) with diisobutylaluminiumhydrid or by Os04-degradation of the allyl alcohol 5.2 was converted to diastereomeric derivatives, inter alia 7 and 9, suitable for 1H-NMR- or HPLC-determination of the absolute configuration of minor amounts of 2. Die Titelverbindung 2 wurde entweder aus dem O-silylierten Milchsäureester 1 durch Reduktion mit Diisobutylaluminiumhydrid oder durch Os04-Abbau des Allylalkohols 5 erhalten. 2 wurde in diastereomere Derivate, u. a. 7 und 9, überführt, die sich zur Bestimmung der absoluten Konfiguration kleiner Mengen von 2 eignen.
Optimization of dyeing process variables for eco-friendly dyeing of cotton fabric with babul bark extract as a natural dye and gallnut extract as a bio-mordant
Creators: name: Dhanania, Yamini
name: Singhee, Deepali
name: Samanta, Ashis K.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: In the present study, cotton fabric has been dyed with aqueous extract of babul bark (Acacia nilotica) using gallnut (Quercus infectoria) as bio-mordant containing hydrolyzable tannins like gallic acid, elagic acid and polyphenolic gallotannins to produce light yellow color. On the other hand when gallnut bio-mordanted cotton is subsequently dyed with babul bark extract as a natural dye containing similar but non-hydrolyzable tannin-rich color component including small amount of catechin and epi-gallo-catechin, it produces a medium to deep brown color through formation of giant insoluble colored complex of cotton-gallotannins (gallnut)-catechin/epigallocatechin and other color components present in babul bark extract. The process variables for extraction, pre-mordanting and dyeing have been optimized to standardize this dyeing technique. Scattered CDI values for dye-bath pH and dye concentration identified them as the most important dyeing parameters that need to be controlled for obtaining uniform dyeing. High UPF value of upto 35 rendered by application of both gallnut and babul bark through preferential absorption of UV light by the gallotannins in both gallnut and babul bark indicates good UV protection properties of dyed cotton fabrics.
Local and nonlocal boundary conditions for $μ$-transmission and fractional elliptic pseudodifferential operators
Creators: name: Grubb, Gerd
Publisher: name: arXiv
Year: 2014
Subjects: subject: Analysis of PDEs (math.AP)
subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 35J75, 35S15, 45E99, 46E35, 58J40

description: A classical pseudodifferential operator $P$ on $R^n$ satisfies the $μ$-transmission condition relative to a smooth open subset $Ω$, when the symbol terms have a certain twisted parity on the normal to $\partialΩ$. As shown recently by the author, the condition assures solvability of Dirichlet-type boundary problems for elliptic $P$ in full scales of Sobolev spaces with a singularity $d^{μ-k}$, $d(x)=\operatorname{dist}(x,\partialΩ)$. Examples include fractional Laplacians $(-Δ)^a$ and complex powers of strongly elliptic PDE. We now introduce new boundary conditions, of Neumann type or more general nonlocal. It is also shown how problems with data on $R^n\setminus Ω$ reduce to problems supported on $\barΩ$, and how the so-called "large" solutions arise. Moreover, the results are extended to general function spaces $F^s_{p,q}$ and $B^s_{p,q}$, including Hölder-Zygmund spaces $B^s_{\infty ,\infty}$. This leads to optimal Hölder estimates, e.g. for Dirichlet solutions of $(-Δ)^au=f\in L_\infty (Ω)$, $u\in d^aC^a(\barΩ)$ when $0
description: Title slightly changed, 34 pages
Ricezione di Paul Ricœur in Italia. L’opera di Domenico Jervolino e il ruolo dell’Istituto Italiano per gli Studi Filosofici di Napoli
Creators: name: Busacchi, Vinicio
Publisher: name: Università degli Studi di Cagliari
Year: 2019

description: Starting thematising Paul Ricoeur’s tardive recognition in France, the author examines in this paper the reception of Paul Ricoeur’s philosophical research in Italy and the role played by this Nation. He particularly focuses on the contribution offered by Domenico Jervolino and Naples’ Istituto Italiano per gli Studi Filosofici (IISF). The perspective of a scholar emerges which both sustained as well as influenced Ricoeur’s work of research and realized in Naples one of the most important laboratories of study and research around different themes. He also generated an original, extraordinarily significant and actual philosophical perspective, that of a philosophy of translation.
description: Critical Hermeneutics, Vol 2, No 2 (2018): Reciprocity as an Ethical-Political Principle: In Memory of Domenico Jervolino (1946-2018)
Degradation of some Phthalideisoquinolines with Ethyl Chloroformate-Stereochemical Aspects
Creators: name: Lee, D.-U.
name: Iwasa, K.
name: Kamigauchi, M.
name: Takao, N.
name: Wiegrebe, Wolfgang
Publisher: name: Universität Regensburg
Year: 1991
Subjects: subject: α-narcotine; β-narcotine; α-hydrastine; β-hydrastine; ethyl chloroformate; diastereoselectivity; enantiomer; diastereomeric carbinol; enol lactone; X-ray analysis; absolute configuration
subject: 540 Chemie

description: Treatment of phthalideisoquinolines such as α- (1) and β-narcotine (2) as well as ß-(3) and α-hydrastine (4) with ethyl chloroformate (ECF) at room temperature afforded, via the chloro-carbamates, the corresponding diastereomeric carbinols with high stereoselectivity. Instrumental analyses of each diastereomeric pair indicate that the major isomers derived from α- and β-narcotine as well as from α - and β -hydrastine are enantiomers of each other. The absolute configuration of the major carbinol 6a from α -narcotine (1) was determined by X-ray analysis. The probable difference between the reaction course of α - and β-narcotine is discussed. On the other hand, treatment of α-narcotine with ECF under reflux furnished Z-(8) and E-(9) enol lactones, while only the Z-isomer 12 could be isolated from the degradation of β-hydrastine (3) even at room temperature.
SaxFDM-Fokusprojekt: OpARA und OpARA4Saxony
Creators: name: Löschen, Christian
Publisher: name: Zenodo
Year: 2022
Subjects: Fokusprojekt
SaxFDM-Tagung

description: OpARA (Open Access Repository and Archive) startete 2018 als gemeinsames ForschungsdatenRepositorium der TU Dresden und der TU Bergakademie Freiberg. Inzwischen wird es von zwei wei­teren sächsischen Hochschulen genutzt. Damit steht den Wissen­schaftlern dieser Einrichtungen ein sächsischer Dienst zur Verfü­gung, um Forschungsdaten gemäß der guten wissenschaftlichen Praxis für mindestens zehn Jahre sicher zu archivieren oder optio­nal langfristig Dritten als OpenAccess-Veröffentlichung zur Verfü­gung zu stellen. In 2022 wird OpARA einem umfassenden Update unterzogen: Die technische Basis wird aktualisiert und die internen Prozesse und Strukturen werden überarbeitet. Basierend auf den Erfah­rungen der ersten Jahre wird unter dem Fokus einer verbes­serten Nutzererfahrung unter anderem der Prozess zur Daten­einreichung optimiert, um erwünschte Funktionen ergänzt und insgesamt schneller und intuitiver gestaltet. Weiterhin startet im Juli 2022 das SaxFDM-Fokusprojekt OpA­RA4Saxony. Im Rahmen dieses Projekts soll für alle interessierten sächsischen Hochschulen als auch die SLUB Dresden die techni­sche Anbindung an OpARA durchgeführt werden. Dabei werden neben den obligatorischen Login-Systemen auch die lokalen For­schungsinformationssysteme sowie Bibliothekskataloge zum au­tomatisierten Austausch von Projekt- und Publikationsdaten an­gebunden. Weitere technische Entwicklungen, z.B. eine Möglichkeit zur Übertragung und Einreichung größerer Datenmengen, sind ebenfalls geplant. Weitere Aufgaben im Projekt sind unter anderem die Einfüh­rung eines Advisory-Boards aus Forschenden der nutzenden Ein­richtungen zur Abstimmung der strategischen Entwicklung von OpARA, die Entwicklung eines langfristig tragfähigen Betriebs- und Finanzierungsmodells, als auch die offizielle Zertifizierung des Re­positoriums durch das Core-Trust-Seal. Das Fokusprojekt wird gemeinsam vom ZIH der TU Dresden und dem URZ der Universität Leipzig durchgeführt.
Traduzione, identità, società. Il caso europeo della molteplicità culturale
Creators: name: Cananzi, Daniele M.
Publisher: name: Università degli Studi di Cagliari
Year: 2019

description: The article discusses the philosophy of the translation of Domenico Jervolino applying it to the case of the European Union. The models of multi-culturalism and interculture are implemented within the EU.
description: Critical Hermeneutics, Vol 2, No 2 (2018): Reciprocity as an Ethical-Political Principle: In Memory of Domenico Jervolino (1946-2018)
Prospects of detection of relic antineutrinos by resonant absorption in electron capturing nuclei
Creators: name: Vergados, J. D.
name: Novikov, Yu. N.
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We consider the possibility of detecting relic anti-neutrinos by their resonant absorption in a nucleus, which can undergo electron capture. This possibility appears quite realistic in view of recent developments in Penning Trap Mass Spectrometry and cryogenic micro-calorimetry.
description: 7 LaTex pages, 5 figures (two new added), 2 tables (one new added); references added, discussion extended, to appear in J. Phys. B (in press)
Fermi Liquids from D-Branes
Creators: name: Rozali, Moshe
name: Smyth, Darren
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We discuss finite density configurations on probe D-branes, in the presence of worldvolume fermions. To this end we consider a phenomenological model whose bosonic sector is governed by the DBI action, and whose charged sector is purely fermionic. In this model, we demonstrate the existence of a compact worldvolume embedding, stabilized by a Fermi surface on the D- brane. The finite density state in the boundary QFT is a Fermi-like liquid. We comment on the possibility of realizing non-Fermi liquids in this setup.
description: Corrected typos
Molecular analysis of different clinical presentations of chronic lymphocytic leukemia reveals novel molecular predictors and molecular heterogenety of different anatomical compartments
Creators: name: Adhinaveni, Ramesh
Publisher: name: Università del Piemonte Orientale
Year: 2022
Subjects: subject: Chronic lymphocytic leukemia (CLL); Small lymphocytic lymphoma (SLL); Fludarabine; cyclophosphamide; rituximab (FCR); BIRC3; cell free DNA (CfDNA) from plasma; genomic DNA (gDNA) from LNF biopsies
subject: Chronic lymphocytic leukemia (CLL)
subject: Small lymphocytic lymphoma (SLL)
subject: Fludarabine
subject: cyclophosphamide
subject: rituximab (FCR)
subject: BIRC3
subject: cell free DNA (CfDNA) from plasma
subject: genomic DNA (gDNA) from LNF biopsies

description: Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL) are different manifestation of the same lymphoproliferative disease. Our study aims at evaluating molecular markers that predispose to chemorefractoriness in CLL and to identify molecular landscape of the different anatomical compartments of SLL. Fludarabine, cyclophosphamide, and rituximab (FCR) is the most effective chemoimmunotherapy regimen for young and fit CLL patients devoid of TP53 disruption. A cohort of 287 patients receiving first-line FCR was analyzed by next generation sequencing (NGS). By univariate analysis, BIRC3 mutations identify a poor prognostic subgroup of patients failing FCR (p<0.001) as cases harboring TP53 mutations (p<0.001). BIRC3 mutations maintained an independent association with an increased risk of progression (p=0.004) in multivariate analysis. By immunoblotting analysis, we showed that the non-canonical NF-KB pathway is active in BIRC3 mutated cell lines and in primary CLL samples. In vitro results indicate that BIRC3 mutated primary CLL cells are less sensitive to fludarabine. BIRC3 mutations may be used as a new molecular predictor to select high-risk patients for novel drugs. Regarding SLL, we investigated 12 SLL patients, provided with: cell free DNA (CfDNA) from plasma, genomic DNA (gDNA) from LNF biopsies, gDNA from CD19+ cells and from CD3+ cells, by using NGS. By comparing mutations identified, SLL genotyping on the cfDNA does not recapitulate SLL genetics and lacks 65.2% identified in the PB CD19+ cells and in the LNF. By considering the 44 mutations identified in the LNF and in the PB CD19+ cells, 20.4% of mutations were unique to the LNF biopsy, 36.4% were unique to the PB CD19+ cells and only 43.2% were shared. The analysis of the LNF only or of the PB CD19+ cell only may miss mutations with potential clinical relevance, suggesting that both these two compartments should be tested to have a comprehensive view of the SLL genetics relevance.
“Healthy aging" goal: the complex associations between senile age depression, fear of falling and risk of falls. A systematic review and meta-analysis of the literature.
Creators: name: Gambaro, Eleonora
Publisher: name: Università del Piemonte Orientale
Year: 2022
Subjects: subject: Depressive symptoms; fear of falling; fall; older people; systematic review; meta-analysis
subject: Depressive symptoms
subject: fear of falling
subject: fall
subject: older people
subject: systematic review
subject: meta-analysis

description: Introduction: Depression rates in older people worldwide vary from 10% to 15% of community-dwelling older persons. The high incidence of falls and the so-called fear of falling (FOF), with a prevalence ranging from 20% to 85%, are two other problems related to depression in old age; it was initially considered a post- fall syndrome, which later as a fall-independent event. Aims: Study aims to conduct a systematic review and meta-analysis to bridge the existing gap in literature about the association between depressive symptomatology, FOF, use of antidepressant therapy and falls, also identifying a possible effect of the study quality on the outcome. Methods: The selection of studies was carried out between May 20, 2020, and July 27, 2020 and only observational clinical trials, written in English, with participants aged more or equal to 60 years affected by diagnosis of depression or treatment for depression mentioned both as a clinical diagnosis in older patient, and as a predictor/consequence of falls were included. The systematic review was performed according to the PRISMA guidelines for reporting systematic reviews and meta-analysis, and the protocol was recorded in the PROSPERO. Results and discussion: The screening process led to the inclusion of 18 articles. Many of the studies showed that depression caused the subsequent increase in the number of falls, but no association between depression and falls, in contrast to other review and meta- analysis works: our work includes a substantial number of studies, with a relatively recent publication date, including patients with depression, clearly evaluating the association between depression and falls. Results all seem to confirm the interdependent association between the presence of FOF and the risk of fall, despite the high percentage of cross-sectional studies prevents inferring on the direction of the association. Therapeutic interventions aimed at decrease rate of falls reducing depressive symptoms and FOF.
Non-destructive X-ray based characterization of materials assisted by multivariate methods of data analysis: from theory to application
Creators: name: Lopresti, Mattia
Publisher: name: Università del Piemonte Orientale
Year: 2022
Subjects: subject: NDT; X-ray radiography; X-Ray diffraction; X-ray tomography; multivariate analysis; PCA; nonlinear regression methods; qualitative analysis; quantitative analysis; gradients; temporal series; microdiffraction; method development; Geant4, X-ray simulation method, X-ray Shielding
subject: NDT
subject: X-ray radiography
subject: X-Ray diffraction
subject: X-ray tomography
subject: multivariate analysis
subject: PCA
subject: nonlinear regression methods
subject: qualitative analysis
subject: quantitative analysis
subject: gradients
subject: temporal series
subject: microdiffraction
subject: method development
subject: Geant4
subject: X-ray simulation method
subject: X-ray Shielding

description: X-ray based non-destructive techniques are an increasingly important tool in many fields, ranging from industry to fine arts, from medicine to basic research. Over the last century, the study of the physical phenomena underlying the interaction between X-rays and matter has led to the development of many different techniques suitable for morphological, textural, elementary, and compositional analysis. Furthermore, with the development of the hardware technology and its automation thanks to IT advancements, enormous progress has been made also from the point of view of data collection and nowadays it is possible to carry out measurement campaigns by collecting many GigaBytes of data in a few hours. Already huge data sets are further enlarged when samples are analyzed with a multi-technique approach and/or at in situ conditions with time, space, temperature, and concentration becoming additional variables. In the present work, new data collection and analysis methods are presented along with applicative studies in which innovative materials have been developed and characterized. These materials are currently of high application interest and involve composites for radiation protection, ultralight magnesium alloys and eutectic mixtures. The new approaches have been grown up from an instrumental viewpoint and with regard to the analysis of the data obtained, for which the use and development of multivariate methods was central. In this context, extensive use has been made of principal component analysis and experimental design methods. One prominent topic of the study involved the development of in situ analysis methods of evolving samples as a response to different types of gradients. In fact, while in large structures such as synchrotrons carrying out analyzes under variable conditions is now consolidated practice, on a laboratory scale this type of experiments is still relatively young and the methods of data analysis of data sets evolving systems have large perspectives for development especially, if integrated by multivariate methods.
Optomechanical signature of a frictionless flow of superfluid light
Creators: name: Larré, P. -É.
name: Carusotto, I.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We propose an experimental setup that should make it possible to reveal the frictionless flow of a superfluid of light from the suppression of the drag force that it exerts onto a material obstacle. In the paraxial-propagation geometry considered here, the photon-fluid dynamics is described by a wave equation analogous to the Gross-Pitaevskii equation of dilute Bose-Einstein condensates and the obstacle consists in a solid dielectric slab immersed into a nonlinear optical liquid. By means of an ab initio calculation of the electromagnetic force experienced by the obstacle, we anticipate that superfluidity is detectable in state-of-the-art experiments from the disappearance of the optomechanical deformation of the obstacle.
description: 10 pages, 4 figures
Methoxy- and Acetoxy-8-oxoberbines-Synthesis, Antitumor-Activity, and Interaction with DNA
Creators: name: Weimar, C.
name: Angerer, S. von
name: Wiegrebe, Wolfgang
Publisher: name: Universität Regensburg
Year: 1991
Subjects: subject: 540 Chemie

description: Most of the memoxy-8H-dibenzo[a,g]isoquinolin-8-ones 3a-h and their acetoxy derivatives 6a-e were synthesized by condensation of 1-oxo-1,2,3,4-tetrahydroisoquinolines 4a-c and homophthalic acid anhydrides 5a and b, ether cleavage and acetylation. These protoberberinones were tested for cytostatic activity in vitro using MDA-MB-231 mammary tumor cells and for interaction with native calf thymus DNA. Tetramethoxy-8-oxoberbine 3f shows an inhibition of cell proliferation of 87% at a concentration of 10-5 mole; its cytostatic effect does not depend on intercalation into DNA. Die meisten der Methoxy-8H-dibenzo[a,g]chinolizin-8-one 3a-h und ihre Acetoxyderjvate 6a-e wurden durch Kondensation der 1-Oxo-1,2,3,4-tetrahydroisochinoline 4a-c mit den Homophthalsäureanhydriden 5a und b, anschließende Etherspaltung und Acetylierung dargestellt. Die cytostatische Wirkung dieser Protoberberinone wurde an der MDA-MB-231-Zellinie, die DNA-Interaktion an nativer Kalbsthymus-DNA geprüft. Das Tetramethoxy- 8-oxoberbin 3f zeigt eine Hemmung der Zellproliferation von 87% bei einer Konzentration von 10-5 M, wobei die cytostatische Wirkung nicht auf eine Interkalation mit der DNA zurückzuführen ist.
Interlingual Aspects Of Wikipedia's Quality
Creators: name: Hammwöhner, Rainer
Publisher: name: Universität Regensburg
Year: 2007
Subjects: subject: 020 Bibliotheks- und Informationswissenschaft

description: This paper presents interim results of an ongoing project on quality issues concerning Wikipedia. One focus of research is the relation of language and quality measurement. The other one is the use of interlingual relations for quality assessment and improvement. The study is based on mono- and multilingual samples of featured and non-featured Wikipedia articles in English, French, German, and Italian that are evaluated automatically.
Multiscale modelling of organic molecules interacting with solids
Creators: name: Marchi, Davide
Publisher: name: Università del Piemonte Orientale
Year: 2022
Subjects: subject: Molecular dynamics; atomistic simulations; surfaces.
subject: Molecular dynamics
subject: atomistic simulations
subject: surfaces

description: This Ph.D. thesis concerns the application of computational chemistry methods to molecular systems of interest, in collaboration with experimental research groups. The bulk of the work was focused on self-assembled monolayers (SAM) of thiol molecules on gold surfaces. SAMs are of central interest in surface science; they are studied for potential applications, among others, in nanolithography, biosensing, and electronics. The nature of the sulfur/gold interface is still debated: although it is commonly held that the –SH moiety dissociates to form a covalent S-Au bond, several studies report SAMs of undissociated thiols. To get insights on this point, we combined density functional theory (DFT) and molecular dynamics (MD) simulations to study in detail the thermodynamics of SAM formation on gold surfaces, using 7-mercapto-4-methylcoumarin (MMC) and 3-mercaptopropionic acid (MPA) as model molecules. The chemical potential of a thiol molecule in the SAM was computed by MD thermodynamic integration as a function of the SAM density; the maximum SAM densities for MMC and MPA in dissociated and undissociated form were computed and compared with experimental results.
Influence of Fine Structure on the Variations of Thermal and Mechanical Properties in Flax Fibers Modified with Different Alkaline Treatment Conditions
Creators: name: Bahrami, Reza
name: Bagheri, Reza
name: Dai, Chunping
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: The alkaline treatment condition plays a crucial role in governing the ultimate properties of flax fibers. In this study, flax fibers were modified with mild alkalization and severe mercerization conditions to give fundamental insight into how the molecular-scale changes in cell wall fine structure and cellulose supramolecular structure can affect the macroscopic properties of fibers. SEM, FTIR, XRD, TGA, and DSC techniques were employed to characterize the variations in morphology, composition, crystalline structure, and thermal properties of fibers. Also, tensile tests evaluated their reinforcing performance in polypropylene-based composites. The results indicated that alkalization in 5% (w/v) NaOH solution preserved the tensile properties of fibers, shifted their thermal decomposition temperature from 198 to 254°C, and effectively decreased their moisture absorption content by 18%. The improvements primarily originate from the partial removal of noncellulosic constituents and promoted crystallinity of native cellulose Iβ structure. However, mercerization in 20% (w/v) solution significantly reduced the rigidity of fibers in the longitudinal direction. Furthermore, it decreased the moisture absorption only by 6% and shifted the thermal degradation to 275°C. The excessive elimination of noncellulosic constituents and the polymorphic transformation, which led to a weaker hydrogen bonding network in the cellulose II region, accounts for these changes.
Logical Error Rate Scaling of the Toric Code
Creators: name: Watson, Fern H. E.
name: Barrett, Sean D.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: To date, a great deal of attention has focused on characterizing the performance of quantum error correcting codes via their thresholds, the maximum correctable physical error rate for a given noise model and decoding strategy. Practical quantum computers will necessarily operate below these thresholds meaning that other performance indicators become important. In this work we consider the scaling of the logical error rate of the toric code and demonstrate how, in turn, this may be used to calculate a key performance indicator. We use a perfect matching decoding algorithm to find the scaling of the logical error rate and find two distinct operating regimes. The first regime admits a universal scaling analysis due to a mapping to a statistical physics model. The second regime characterizes the behavior in the limit of small physical error rate and can be understood by counting the error configurations leading to the failure of the decoder. We present a conjecture for the ranges of validity of these two regimes and use them to quantify the overhead -- the total number of physical qubits required to perform error correction.
description: 12 pages, 12 figures
Role of ER Stress in the pathogenesis of Celiac Disease
Creators: name: Monzani, Romina
Publisher: name: Università del Piemonte Orientale
Year: 2022

description: Celiac disease (CD) is a complex inflammatory and auto-immune disorder triggered by the ingestion of gluten, a heterogeneous mixture of seed-storage proteins, such as gliadins, present in cereals as wheat, barley, rye and oats, in genetically predisposed individuals. The disease occurs in 1% worldwide population, and its onset has genetic, immunological and environmental components. Currently, the molecular mechanisms through which gliadin triggers the CD onset are not yet completely clear. The only treatment for the disease is represented by a gluten-free diet (GFD) which is not 100% effective and is difficult to adhere by patients. In this study, we demonstrated that gliadin stimulation induces ER stress in IEC, by using both in vitro and ex vivo models. Importantly, our results indicate that ER stress has a key role in the pathogenesis of CD. At molecular level we found that extracellular gliadin peptides interact with CXCR3 at plasma membrane level which, in turn, induce the release of IP3 through the stimulation of PLC. The interaction of IP3 with IP3R onto ER membranes results in calcium release by the ER compartment thus inducing ER stress. Of note, buffering the gliadin-induced ER stress by the chemical chaperone 4PBA completely abrogates the cytopathic effects of gliadin. Moreover, we also show that gliadin-induced ER stress is responsible for: i) CXCR3 gene expression upregulation, through CHOP; ii) TG2 gene expression upregulation, through both canonical and non-canonical activation of NF-kB; iii) altered intestinal permeability; and iv) induction and release of pro-inflammatory cytokines. Therefore, our results indicate that ER stress might represent a valuable target to design a new clinical therapeutic approach to treat CD patients.
Optically Active Intermediate from Degradation of (-)-Laudanosine, a Benzylisoquinoline Alkaloid, with Ethyl Chloroformate
Creators: name: Lee, D.-U.
name: Wiegrebe, Wolfgang
Publisher: name: Universität Regensburg
Year: 1991
Subjects: subject: 540 Chemie

description: Degradation of (—)-laudanosine, a 1-benzyl-1,2,3,4-tetrahydroisoquinoline alkaloid, with ethyl chloroformate (ECF) afforded an optically active chloro-carbamate as an intermediate. The reason why this intermediate exhibits an optical activity was investigated by comparison with the reactions of some model compounds with ECF. It may be supposed that the chloride group in a hypothetic carbenium ion intermediate stands very closely to the chiral center, so conserving optical activity. However, a neighboring group effect can not be excluded.
Ricœur lettore dell’Amore difficile. In dialogo  con Domenico Jervolino
Creators: name: Caputo, Annalisa
Publisher: name: Università degli Studi di Cagliari
Year: 2019

description: Starting from the Préface written by Paul Ricoeur for the text L’amore difficile (Jervolino, 1995), this paper reconstructs the dialogue woven by the two thinkers on this issue, underlining the (methodological and hermeneutical) convergences, but also the inevitable divergences. A philosophical hermeneutics in which philosophy includes itself and its other (i. e. biblical thought): «this hermeneutics, in my opinion, remains to be thought» – Ricoeur notes. Can we maybe say that this hermeneutic of the ‘difficult love’ has been written by Domenico Jervolino, in a way that, after all, is – compared to his 'mentor' – the same one and an other one?
description: Critical Hermeneutics, Vol 2, No 2 (2018): Reciprocity as an Ethical-Political Principle: In Memory of Domenico Jervolino (1946-2018)
The phase diagram of the antiferromagnetic XXZ model on the triangular lattice
Creators: name: Sellmann, Daniel
name: Zhang, Xue-Feng
name: Eggert, Sebastian
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We determine the quantum phase diagram of the antiferromagnetic spin-1/2 XXZ model on the triangular lattice as a function of magnetic field and anisotropic coupling $J_z$. Using the density matrix renormalization group (DMRG) algorithm in two dimensions we establish the locations of the phase boundaries between a plateau phase with 1/3 Néel order and two distinct coplanar phases. The two coplanar phases are characterized by a simultaneous breaking of both translational and U(1) symmetries, which is reminiscent of supersolidity. A translationally invariant umbrella phase is entered via a first order phase transition at relatively small values of $J_z$ compared to the corresponding case of ferromagnetic hopping and the classical model. The phase transition lines meet at two tricritical points on the tip of the lobe of the plateau state, so that the two coplanar states are completely disconnected. Interestingly, the phase transition between the plateau state and the upper coplanar state changes from second order to first order for large values of $J_z > 2.5J$.
description: 8 pages including 13 figures with more data and more details on the 2D DMRG numerics. For the latest version and more information see http://www.physik.uni-kl.de/eggert/papers/index.html
Deciphering the molecular mechanisms orchestrating myeloid-derived immunosuppression in cancer and therapy
Creators: name: Pandolfo, Chiara
Publisher: name: Università del Piemonte Orientale
Year: 2022
Subjects: subject: Non-small-cell lung cancer (NSCLC); myeloid cells; myeloid-derived suppressor cells (MDSCs); “emergency" myelopoiesis; RNA-sequencing; tumor progression; immunotherapy; immune checkpoint blockade (ICB)
subject: Non-small-cell lung cancer (NSCLC)
subject: myeloid cells
subject: myeloid-derived suppressor cells (MDSCs)
subject: “emergency" myelopoiesis
subject: RNA-sequencing
subject: tumor progression
subject: immunotherapy
subject: immune checkpoint blockade (ICB)

description: Immunotherapy has revolutionized the treatment of several human cancers, including non-small cell lung cancer (NSCLC). However, treatment with immune checkpoint blockade (ICB) is not beneficial for the majority of patients, as many of them exhibit partial clinical responses, as well as adverse effects. One of the great challenges of cancer care is to reconcile the high therapeutic efficacy of immunotherapy with low toxicity, deciphering the molecular network controlling cancer-related immune alterations and identifying putative prognostic markers and therapeutic targets. During cancer progression, myeloid-derived suppressor cells (MDSCs) abundantly expand, resulting in hampered anti-tumor adaptive immune responses and thus contributing to tumor progression and resistance to immunotherapy. Hence, understanding the molecular basis underlying the immunosuppressive features of cancer associated myeloid cells, is a crucial step for the identification of potential markers of tumor progression and response to therapy. By flow cytometry analysis we demonstrated a significant expansion of MDSCs related to cancer stage, suggesting an active role of these cells in fueling tumor progression. Moreover, in an cohort of advanced NSCLC patients, we observed a negative correlation between the M-MDSC/Tcell, monocyte/Tcell ratios and patient's response to ICB treatment. Since the myeloid compartment in the tumor tissue has specific correlations with the corresponding one in peripheral blood, we investigated by RNA-sequencing the transcriptional profile of circulating monocytes and M-MDSCS of NSCLC patients. Our results revealed a tumor-stage dependent evolution of blood monocyte and M-MDSC transcriptional signatures, which is reflected in metabolic alterations occurring in these cells during cancer development. Accordingly, transcriptional landscapes of monocytes and M-MDSCs of advanced NSCLC, detected prior to ICB treatment, appear to be predictive of the patient's clinical response.
Finite size effects in a mean-field kinetically constrained model: dynamical glassiness and quantum criticality
Creators: name: Nemoto, Takahiro
name: Lecomte, Vivien
name: Sasa, Shin-ichi
name: van Wijland, Frédéric
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: On the example of a mean-field Fredrickson-Andersen kinetically constrained model, we focus on the known property that equilibrium dynamics take place at a first-order dynamical phase transition point in the space of time-realizations. We investigate the finite-size properties of this first order transition. By discussing and exploiting a mapping of the classical dynamical transition -an argued glassiness signature- to a first-order quantum transition, we show that the quantum analogy can be exploited to extract finite-size properties, which in many respects are similar to those in genuine mean-field quantum systems with a first-order transition. We fully characterize the finite-size properties of the order parameter across the first order transition.
Alcune note sulla ricezione ricœuriana di Heidegger. A partire da Il cogito e l’ermeneutica di  Domenico Jervolino
Creators: name: Casucci, Marco
Publisher: name: Università degli Studi di Cagliari
Year: 2019

description: The aim of this contribution is to recall the problem of the Ricoeurian reception of Heidegger’s thought, starting from the interpretation given by Domenico Jervolino in his book Il cogito e l’ermeneutica. This interpretation will be highlighted as an opportunity to rediscover both the continuity and discontinuity between the Heideggerian and Ricoeurian hermeneutics. In this sense will be shown their common aim to disclose the possibility of a philosophical openness on the threshold of thinking, in order to make it possible an emersion of the transcendence as a specific place of the manifestation/revelation of the truth.
description: Critical Hermeneutics, Vol 2, No 2 (2018): Reciprocity as an Ethical-Political Principle: In Memory of Domenico Jervolino (1946-2018)
Liquid biopsy provides complementary information to tissue biopsies for molecular classification of DLBCL patients
Creators: name: SAGIRAJU, Sruthi
Publisher: name: Università del Piemonte Orientale
Year: 2022
Subjects: subject: Diffuse large B-cell lymphoma(DLBCL); lymph node biopsy (LN); circulating tumor DNA (ctDNA) LymphGen tool
subject: Diffuse large B-cell lymphoma(DLBCL)
subject: lymph node biopsy (LN)
subject: circulating tumor DNA (ctDNA) LymphGen tool

description: Diffuse large B-cell lymphoma is a molecular heterogeneous disease with a variable clinical course and prognosis. Recent studies have identified different molecular clusters on tissue biopsy. Liquid biopsy is a non-invasive tool that allows the collection of circulating tumor DNA (ctDNA) shed by apoptotic tumor cells potentially deriving from all the different sites of the lymphoma. This may provide an integrative source of tumor DNA for DLBCL genotyping. The aims of the study are: i) to identify new prognostic molecular markers on ctDNA and on lymph node biopsy (LN); and ii) to compare the DLBCL molecular clusters between the LN and the ctDNA. The mutational profiling performed in 77 DLBCL patients, through a NGS approach, allows to identify at least one somatic non-synonymous mutation in 92.2% of patients in the LN biopsy, and in 87.0% in the ctDNA. Mutation analysis of different compartments allowed to identify mutations with potential clinical impact: GRHPR (p=0.035) and SGK1 (p=0.039) mutations in ctDNA, and MYC mutations in LN (p=0.021) were associated with a shorter PFS. Moreover, ctDNA levels harbor prognostic impact since higher levels of ctDNA (22.5 log hGE/mL) showed a significantly worse PFS (p=0.025) and OS (p=0.004). Based on the mutations identified, the LymphGen tool allowed to assign to a specific molecular cluster 46.5% of patients on the LN biopsy, and 40.3% on the liquid biopsy. The combination of mutational data from LN and ctDNA improved DLBCL assignment to a specific cluster, thus classifying 48.7% of cases. From a clinical perspective, patients belonging to the BN2 and ST2 clusters showed a favorable outcome with a 36-month PFS of 100% compared to 62.3% for patients belonging to the MCD or EZB clusters (p=0.040). The combination of mutational data from LN and ctDNA provides complementary information for the molecular classification and prognostic stratification of newly diagnosed DLBCL patients.
Per un’ermeneutica dell’incompiutezza.  Ricœur e Jervolino in dialogo
Creators: name: Valenza, Pierluigi
Publisher: name: Università degli Studi di Cagliari
Year: 2019

description: The essay deals with two texts within Jervolino's wide scientific production consecrated to Ricoeur's work. The first one, Ricoeur. L’amore difficile (1994), reflecting on the results of Ricœur's work Soi-même comme un autre looks for a philosophical hermeneutics of the biblical faith as fulfilment of ricoeurian project. In his Preface to this book Ricoeur acknowledges such hermeneutics as lacking. The second one, an article published in 2004 in the review «Archives de Philosophie», point out the topic of translation as a possible paradigm of ricoeurian thinking looking at his last main book, La mémoire, l'histoire, l'oubli. In this article Jervolino seems to accept the openness of life and therefore the incompleteness at the end of Ricoeur's work. In the last paragraph of the essay these topics are connected to Ricoeur's idea of phenomenology of religion in which translation as paradigm plays an important role and its link to forgiveness is cleared.
description: Critical Hermeneutics, Vol 2, No 2 (2018): Reciprocity as an Ethical-Political Principle: In Memory of Domenico Jervolino (1946-2018)
Synthesis of the Preininger-Alkaloid and its Enantioselective Reduction to Macrostomine
Creators: name: Mahboobi, Siavosh
name: Wiegrebe, Wolfgang
Publisher: name: Universität Regensburg
Year: 1991
Subjects: subject: 540 Chemie

description: The Preininger-alkaloid, dehydro-normacrostomine (2b, Scheme 1) was synthesized starting from rac. α-acetyl-3,4-dimethoxybenzylcyanide (3) (Scheme 2). The key intermediate 4-acetyl-6,7-dimethoxy-l-(3,4-methylenedioxybenzyl) isoquinoline (11) is converted via a Mannich base to the nitrile 17 (Scheme 7) which in turn is cyclized to the Preininger-alkaloid (2b) by careful hydrogenation. - Reduction of 2b with a modified Iwakuma-reagent followed by N-formylation and subsequent LiAlH4-reduction produced (R)- (+)-macrostomine (enantiomer of 1) in 72 % optical purity. Das Preininger-Alkaloid (Dehydro-normacrostomin, 2b, Scheme 1) wurde ausgehend von rac. α-Acetyl-3,4-dimethoxybenzylcyanid (3) über die Schlüsselverbindung 4-Acetyl-6,7-dimethoxy-1 -(3,4-methylendioxybenzyl) isochinolin (11) synthetisiert. Die Umsetzung von 11 über eine Mannich- Base zum Nitril 17 (Scheme 7) und dessen schonende Hydrierung führten zum Preininger-Alkaloid (2b). - Die Reduktion von 2b mit einem modifizierten Iwokuma-Reagenz, N-Formylierung und Alanat-Reduktion lieferten (R)-(+)-Macrostomin (Enantiomer von 1) in 72 proz. optischer Reinheit
Domenico Jervolino, ovvero la scomparsa di un amico
Creators: name: Iannotta, Daniella
Publisher: name: Università degli Studi di Cagliari
Year: 2019

description: La scomparsa di un amico, Domenico Jervolino, apre per noi il tempo della memoria, affidandoci il compito di saggiare l’enigmatico rapporto di assenza/presenza della persona cara. Presenza dell’opera, in questo caso, con cui ci è dato di continuare a dialogare nell’atto della lettura. Presenza dei ricordi che ci legano all’amico, consentendoci di ripetere quasi – in immaginazione e simpatia – le vicende vissute insieme in una incessante e feconda operazione di riscrittura del loro senso...
description: Critical Hermeneutics, Vol 2, No 2 (2018): Reciprocity as an Ethical-Political Principle: In Memory of Domenico Jervolino (1946-2018)
Adaptive Zero Reaction Motion Control for Free-Floating Space Manipulators
Creators: name: Xu, Shuanfeng
name: Wang, Hanlei
name: Zhang, Duzhou
name: Yang, Baohua
Publisher: name: arXiv
Year: 2014
Subjects: subject: Systems and Control (eess.SY)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: This paper investigates adaptive zero reaction motion control for free-floating space manipulators with uncertain kinematics and dynamics. The challenge in deriving the adaptive reaction null-space (RNS) based control scheme is that it is difficult to obtain a linear expression, which is the basis of the adaptive control. The main contribution of this paper is that we skillfully obtain such a linear expression, based on which, an adaptive version of the RNS-based controller (referred to as the adaptive zero reaction motion controller in the sequel) is developed at the velocity level, taking into account both the kinematic and dynamic uncertainties. It is shown that the proposed controller achieves both the spacecraft attitude regulation and end-effector trajectory tracking. The performance of the proposed adaptive controller is shown by numerical simulations with a planar 3-DOF (degree-of-freedom) space manipulator.
description: 17 pages, 9 figures, revised for more rigorously presenting the proof and for improving the presentation, highlighting the contribution, and correcting some typos based on the reviewers' and AE's comments from IEEE Transactions on Aerospace and Electronic Systems
Electric field control of magnetic properties and magneto-transport in composite multiferroics
Creators: name: Udalov, O. G.
name: Chtchelkatchev, N. M.
name: Beloborodov, I. S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We study magnetic state and electron transport properties of composite multiferroic system consisting of a granular ferromagnetic thin film placed above the ferroelectric substrate. Ferroelectricity and magnetism in this case are coupled by the long-range Coulomb interaction. We show that magnetic state and magneto-transport strongly depend on temperature, external electric field, and electric polarization of the substrate. Ferromagnetic order exists at finite temperature range around ferroelectric Curie point. Outside the region the film is in the superparamagnetic state. We demonstrate that magnetic phase transition can be driven by an electric field and magneto-resistance effect has two maxima associated with two magnetic phase transitions appearing in the vicinity of the ferroelectric phase transition. We show that positions of these maxima can be shifted by the external electric field and that the magnitude of the magneto-resistance effect depends on the mutual orientation of external electric field and polarization of the substrate.
description: 22 pages 11 figures