cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
IMPROVING STUDENTS' WRITING DESCRIPTIVE TEXT COMPETENCE USING MAPPING PICTURES
Creators: name: Winurati, Sutri
name: Sulistyaningsih
name: Vinola, Okky Ria
Publisher: name: Zenodo
Year: 2022
Subjects: APPI PT PGRI
PGRI
ICDESS2022
WRITING DESCRIPTIVE TEXT COMPETENCE
Mapping Pictures

description: This material was presented in ACT +1 activities and International Conference on Digital Education and Social Science as a presenter
title: Age- and Disease-Related Changes in Signal Intensity in the Superior Cerebellar Peduncles on Three-Dimensional T2-Weighted FLAIR
Creators: name: Toyoda, Keiko
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Image verification
subject: Imaging sequences
subject: MR
subject: Anatomy
subject: Neuroradiology brain

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: In 3D T2-weighted fluid-attenuated inversion recovery (3DT2 FLAIR) , contrast of the normal brain stem demonstrates higher intensity in the superior cerebellar peduncles (SCP) and decussation of the SCP, compared with surrounding regions. In cases...
(101270) Alexander Walton King
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Transformation of marketing in the e-commerce
Creators: name: Kaluzhsky, Mikhail
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computers and Society (cs.CY)
subject: FOS: Computer and information sciences

description: The article is about transformation of the theory and practice of marketing in the conditions of e-commerce and network economy. The author considers Internet-marketing as an independent kind of marketing in the virtual communicative environment. The basic thesis of the article: the virtual environment defines marketing transformation, changing methods, priorities and structure at practice and then theories of marketing.
description: 13 pages, in Russian. ISSN 2071-3762
Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys
Creators: name: Hirabayashi, T.
name: Shimojo, M.
name: Fujimoto, A.
name: Roth, B.L.
name: Hori, Y.
name: Zhang, M.-R.
name: Ono, M.
name: English, J.G.
name: Miyakawa, N.
name: Takahashi, M.
name: DiBerto, J.F.
name: Higuchi, M.
name: Takuwa, H.
name: Nakahara, J.
name: Slocum, S.T.
name: Nagai, Y.
name: Suhara, T.
name: Tomita, Y.
name: Huang, X.-P.
name: Oyama, K.
name: Ji, B.
name: Inoue, K.-I.
name: Takada, M.
name: Seki, C.
name: Kumata, K.
name: Minamimoto, T.
name: Jin, J.
name: Mimura, K.
name: Xiong, Y.
name: Liu, J.
name: Urushihata, T.
Publisher: name: Nature Research
Year: 2020

description: The chemogenetic technology designer receptors exclusively activated by designer drugs (DREADDs) afford remotely reversible control of cellular signaling, neuronal activity and behavior. Although the combination of muscarinic-based DREADDs with clozapine-N-oxide (CNO) has been widely used, sluggish kinetics, metabolic liabilities and potential off-target effects of CNO represent areas for improvement. Here, we provide a new high-affinity and selective agonist deschloroclozapine (DCZ) for muscarinic-based DREADDs. Positron emission tomography revealed that DCZ selectively bound to and occupied DREADDs in both mice and monkeys. Systemic delivery of low doses of DCZ (1 or 3 μg per kg) enhanced neuronal activity via hM3Dq within minutes in mice and monkeys. Intramuscular injections of DCZ (100 μg per kg) reversibly induced spatial working memory deficits in monkeys expressing hM4Di in the prefrontal cortex. DCZ represents a potent, selective, metabolically stable and fast-acting DREADD agonist with utility in both mice and nonhuman primates for a variety of applications.
The activities of drug inactive ingredients on biological targets
Creators: name: Urban, L.
name: Fekete, A.
name: Giacomini, K.M.
name: Shoichet, B.K.
name: Berg, E.L.
name: Lukacs, K.V.
name: Ghaemi, S.N.
name: Bednarczyk, D.
name: Irwin, J.J.
name: Zou, L.
name: Jin, H.
name: Pottel, J.
name: Armstrong, D.
name: Slocum, S.
name: Roth, B.L.
name: Bhhatarai, B.
name: Huang, X.-P.
name: Whitebread, S.
name: Torosyan, H.
name: Liang, G.
Publisher: name: American Association for the Advancement of Science
Year: 2020

description: Excipients, considered "inactive ingredients," are a major component of formulated drugs and play key roles in their pharmacokinetics. Despite their pervasiveness, whether they are active on any targets has not been systematically explored. We computed the likelihood that approved excipients would bind to molecular targets. Testing in vitro revealed 25 excipient activities, ranging from low-nanomolar to high-micromolar concentration. Another 109 activities were identified by testing against clinical safety targets. In cellular models, five excipients had fingerprints predictive of system-level toxicity. Exposures of seven excipients were investigated, and in certain populations, two of these may reach levels of in vitro target potency, including brain and gut exposure of thimerosal and its major metabolite, which had dopamine D3 receptor dissociation constant Kd values of 320 and 210 nM, respectively. Although most excipients deserve their status as inert, many approved excipients may directly modulate physiologically relevant targets.
Designing Functionally Selective Noncatechol Dopamine D1 Receptor Agonists with Potent in Vivo Antiparkinsonian Activity
Creators: name:  Jin, J.
name:  Ray, C.
name:  Yu, X.
name:  Wetsel, W.C.
name:  McCorvy, J.D.
name:  Caron, M.G.
name:  Huang, X.-P.
name: Martini, M.L.
name:  Liu, J.
name:  Pogorelov, V.M.
Publisher: name: American Chemical Society
Year: 2019

description: Dopamine receptors are important G protein-coupled receptors (GPCRs) with therapeutic opportunities for treating Parkinson's Disease (PD) motor and cognitive deficits. Biased D1 dopamine ligands that differentially activate G protein over β-arrestin recruitment pathways are valuable chemical tools for dissecting positive versus negative effects in drugs for PD. Here, we reveal an iterative approach toward modification of a D1-selective noncatechol scaffold critical for G protein-biased agonism. This approach provided enhanced understanding of the structural components critical for activity and signaling bias and led to the discovery of several novel compounds with useful pharmacological properties, including three highly GS-biased partial agonists. Administration of a potent, balanced, and brain-penetrant lead compound from this series results in robust antiparkinsonian effects in a rodent model of PD. This study suggests that the noncatechol ligands developed through this approach are valuable tools for probing D1 receptor signaling biology and biased agonism in models of neurologic disease.
(101271) George Daventry
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Design, Synthesis, and Characterization of Ogerin-Based Positive Allosteric Modulators for G Protein-Coupled Receptor 68 (GPR68)
Creators: name: Kenakin, T.P.
name: Martini, M.L.
name: Yu, X.
name: Liu, J.
name: Jin, J.
name: Huang, X.-P.
name: Slocum, S.T.
name: Chen, X.
Publisher: name: American Chemical Society
Year: 2019

description: G protein-coupled receptor 68 (GPR68) is an understudied orphan G protein-coupled receptor (GPCR). It is expressed most abundantly in the brain, potentially playing important roles in learning and memory. Pharmacological studies with GPR68 have been hindered by lack of chemical tools that can selectively modulate its activity. We previously reported the first small-molecule positive allosteric modulator (PAM), ogerin (1), and showed that 1 can potentiate proton activity at the GPR68-Gs pathway. Here, we report the first comprehensive structure-activity relationship (SAR) study on the scaffold of 1. Our lead compound resulted from this study, MS48107 (71), displayed 33-fold increased allosteric activity compared to 1. Compound 71 demonstrated high selectivity over closely related proton GPCRs and 48 common drug targets, and was bioavailable and brain-penetrant in mice. Thus, our SAR study has resulted in an improved GPR68 PAM for investigating the physiological and pathophysiological roles of GPR68 in vitro and in vivo.
title: Thoracic manifestations of hydatidosis : Pictorial review
Creators: name: Aouini, Rim
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Thorax
subject: Mediastinum
subject: Lung
subject: CT
subject: MR
subject: Education
subject: Cysts
subject: Infection
subject: Parasites

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The aim of this exhibit is to illustratethe different radiological manifestations of hydatidosis, depending on its location in the...
(101272) Eleanor Annie King
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
DREADD Agonist 21 is an effective agonist for muscarinic-based DREADDs in vitro and in vivo
Creators: name: Slocum, S.
name: Diberto, J.F.
name: Kash, T.L.
name: Tobin, A.B.
name: Roth, B.L.
name: Liu, J.
name: Bradley, S.J.
name: Navarrete, J.S.
name: Jin, J.
name: Pati, D.
name: Molloy, C.
name: Khajehali, E.
name: Boyt, K.M.
name: Thompson, K.J.
name: Christopoulos, A.
name: Pina, M.M.
name: Olsen, R.H.J.
name: Xiong, Y.
name: Krashes, M.J.
name: Huang, X.P.
name: Bundgaard, C.
name: Sexton, P.M.
Publisher: name: American Chemical Society
Year: 2018

description: Chemogenetic tools such as designer receptors exclusively activated by designer drugs (DREADDs) are routinely used to modulate neuronal and non-neuronal signaling and activity in a relatively noninvasive manner. The first generation of DREADDs were templated from the human muscarinic acetylcholine receptor family and are relatively insensitive to the endogenous agonist acetylcholine but instead are activated by clozapine-N-oxide (CNO). Despite the undisputed success of CNO as an activator of muscarinic DREADDs, it has been known for some time that CNO is subject to a low rate of metabolic conversion to clozapine, raising the need for alternative chemical actuators of muscarinic-based DREADDs. Here we show that DREADD agonist 21 (C21) (11-(1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine) is a potent and selective agonist at both excitatory (hM3Dq) and inhibitory (hM4Di) DREADDs and has excellent bioavailability, pharmacokinetic properties, and brain penetrability. We also show that C21-induced activation of hM3Dq and hM4Di in vivo can modulate bidirectional feeding in defined circuits in mice. These results indicate that C21 represents an alternative to CNO for in vivo studies where metabolic conversion of CNO to clozapine is a concern.
Central compact objects in Kes 79 and RCW 103 as "hidden" magnetars with crustal activity
Creators: name: Popov, S. B.
name: Kaurov, A. A.
name: Kaminker, A. D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We propose that observations of "hidden" magnetars in central compact objects can be used to probe crustal activity of neutron stars with large internal magnetic fields. Estimates based on calculations by Perna \& Pons (2011), Pons \& Rea (2012) and Kaminker et al. (2014) suggest that central compact objects, which are proposed to be "hidden" magnetars, must demonstrate flux variations on the time scale of months-years. However, the most prominent candidate for the "hidden" magnetars --- CXO J1852.6+0040 in Kes 79, -- shows constant (within error bars) flux. This can be interpreted by lower variable crustal activity than in typical magnetars. Alternatively, CXO J1852.6+0040 can be in a high state of variable activity during the whole period of observations. Then we consider the source 1E161348-5055 in RCW103 as another candidate. Employing a simple 2D-modeling we argue that properties of the source can be explained by the crustal activity of the magnetar type. Thus, this object may be supplemented for the three known candidates for the "hidden" magnetars among central compact objects discussed in literature.
description: 8 pages, accepted to PASA
Protamine is an antagonist of Apelin receptor, and its activity is reversed by heparin
Creators: name: Barak, L.S.
name: Le Gonidec, S.
name: Wanecq, E.
name: Roth, B.L.
name: Masri, B.
name: Audigier, Y.
name: Huang, X.-P.
name: Knibiehler, B.
name: Bai, Y.
name: Chaves-Almagro, C.
name: Prats, H.
name: Smith, A.
name: Caron, M.G.
name: Kang, H.J.
name: Valet, P.
Publisher: name: FASEB
Year: 2017

description: In the accompanying Comment, Suzuki et al. confirmed our previous findings that the ketamine metabolite (2R,6R)-hydroxynorketamine (HNK) does not functionally inhibit the NMDAR at concentrations relevant to its antidepressant actions recently reported in mice (that is, approximately 10 μM).
title: Top 10 Things You Don't Want To Miss: Breast Imaging
Creators: name: Figueroa-Diaz, Laura
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Cancer
subject: Normal variants
subject: Ultrasound
subject: Mammography
subject: Breast
subject: Anatomy

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Review mammography imaging protocol. Recognize normal imaging variants and benign asymmetric breast patterns. Differentiate between types of calcifications. Review common findings in the nipple-areolar complex. Distinguish between mastitis and...
Disposition of acetaminophen and indocyanine green in cystic fibrosis-knockout mice
Creators: name: Pegram, Anita A.
name: Smith, Philip C.
name: Kulkarni, Swarupa G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: Drug treatment poses a therapeutic challenge in cystic fibrosis (CF) because the disposition of a number of drugs is altered in CF. Enhanced clearance of acetaminophen (APAP) and indocyanine green (ICG) have previously been reported in CF patients. The objective of the current study was to investigate if the CF-knockout mouse model (cftrm1UNC) shows altered pharmacokinetics similar to those seen in CF patients using the 2 model compounds APAP and ICG. Clearance (CL/F) of APAP and renal (CLR) and formation (CLf) clearance of acetaminophen glucuronide (AG) and acetaminophen sulfate (AS) were determined in CF-knockout mice following administration of APAP (50 mg/kg, intraperitoneal). CLR of AS was 19.5 and 12.9 (mL/min per kg) and CLf of AS was 10.4 and 6.7 mL/min per kg for homozygous and heterozygous males, respectively, which was significantly different between groups. CLR of AG was 6.3 and 4.8 mL/min per kg and CLf of AG was 9.6 and 8.9 mL/min per kg for homozygous and heterozygous males, respectively, although not reaching statistical significance. No significant differences were noted in either ClR or CLf of AG and AS in female CF mice. Plasma concentrations of ICG (10 mg/kg, intravenous) were determined over 0 to 15 minutes. Homozygous females showed a higher apparent volume of distribution (96 mL/kg) relative to heterozygous females (72 mL/kg). Similar to CF patients, a trend toward a lower Cmax was noted in homozygous male and female mice. However, contrary to human data, no significant differences in CL of ICG were noted. These results suggest that the CF-knockout mice have potential as a model for studying altered drug disposition in CF patients.
Detailing the equivalence between real equiangular tight frames and certain strongly regular graphs
Creators: name: Fickus, Matthew
name: Watson, Cody E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 42C15

description: An equiangular tight frame (ETF) is a set of unit vectors whose coherence achieves the Welch bound, and so is as incoherent as possible. They arise in numerous applications. It is well known that real ETFs are equivalent to a certain subclass of strongly regular graphs. In this note, we give some alternative techniques for understanding this equivalence. In a later document, we will use these techniques to further generalize this theory.
Experiment Results and Replication Package of FITNESS
Creators: name: Anonymous
Publisher: name: Zenodo
Year: 2023
Subjects: Bias Mitigation, Machine Learning Software

description: These are the result of FITNESS and 7 existing bais-mitigating methods. The file name indicates the experiment setting. For instance, fitness_lr_adult_race.txt means this case is a logistic regression model applied FITNESS to protect the race feature in the Adult Census Income dataset. ".txt" means file type. Each file in the folder has 53 columns, with the first column indicating the ML performance or fairness metric, the next 50 columns the metric values of 50 runs, and the last two columns the mean and standard values of the 50 runs.
Semi-classical Dirac vacuum polarisation in a scalar field
Creators: name: Lampart, Jonas
name: Lewin, Mathieu
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We study vacuum polarisation effects of a Dirac field coupled to an external scalar field and derive a semi-classical expansion of the regu-larised vacuum energy. The leading order of this expansion is given by a classical formula due to Chin, Lee-Wick and Walecka, for which our result provides the first rigorous proof. We then discuss applications to the non-relativistic large-coupling limit of an interacting system, and to the stability of homogeneous systems.
description: Revised version to appear in AHP (DOI: 10.1007/s00023-016-0472-y)
Effect of chloroquine on phagolysosomal fusion in cultured guinea pig alveolar macrophages: Implications in drug delivery
Creators: name: Bhat, Meenakshi
name: Hickey, Anthony J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: The aim of this study was to evaluate the effects of chloroquine on phagolysosomal fusion (PLF) in cultured guinea pig alveolar macrophages (AMs). This technique may be of significance for antitubercular drugs, because the survival of Mycobacterium tuberculosis is linked to evasion of PLF. Guinea pig AMs were obtained from anesthetized animals after exsanguination. The AMs were cultured at a density of 1×106 cell/mL in 24-well plates after attachment to 13-mm coverslips. Culture conditions were at 37°C, with 95% air/5% CO2 in Roswell Park Memorial Institute (RPMI) 1640 medium with 10% heat-inactivated fetal bovine serum. Rhodamine-dextran (70 kd) was incubated with the cells at 0.25 mg/mL for 24 hours to label the lysosomes. Chloroquine treatment where indicated was performed at 10–20 μ g/mL for 1 hour. Fluorescent BioParticles were then added, and PLF was monitored by formation of an organge-yellow fluorescence on fusion of green fluorescent BioParticles with rhodamine-labeled lysosomes. PLF endpoints were measured by scoring for the percentage of orange-yellow cells in the field of view. Image analysis to measure the intensity of the orange-yellow color was performed by obtaining a, b values for 5×5 pixel areas using the Photo Adobe program 4.0.1.
title: Gastrointestinal Stromal Tumors: The Role of The Radiologist
Creators: name: Gaio, Raquel
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Abdomen
subject: Oncology
subject: CT
subject: MR
subject: PET-CT
subject: Diagnostic procedure
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To review the spectrum of multimodality imaging appearances of gastrointestinal stromal tumors (GISTs). To understand the role of radiologists and comprehend the imaging signs that allow: 1) detection, diagnosis and characterization of primary...
Evaluation of novel particles as pulmonary delivery systems for insulin in rats
Creators: name: Bell, Steve J.D.
name: Morçöl, Tülin
name: Garcia-Contreras, Lucila
name: Hickey, Anthony J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: The purpose of the study was to evaluate the influence of calcium phosphate (CAP) and polyethylene glycol (PEG) particles on the systemic delivery of insulin administered by the pulmonary route. Two methods of pulmonary delivery were employed: intratracheal instillation and spray instillation. Insulin-CAP-PEG particles in suspension (1.2 U/kg, 110–140 μL) were administered to the lungs of fasted rats by intratracheal instillation (INCAPEG) or spray instillation (SINCAPEG). Control treatments consisted of insulin solution (1.2 U/kg) by intratracheal instillation, spray instillation, and subcutaneous administration (SC). Plasma concentrations of insulin and glucose were determined by chemiluminescence and colorimetric methods, respectively. Data were analyzed by compartmental and non-compartmental methods, and pharmacokinetic (PK) and pharmacodynamic (PD) parameters of insulin disposition were determined. PK analysis suggested that insulin administered in particles had a longer half-life, a longer mean residence time, and a smaller rate of elimination than insulin in solution. In addition, insulin bioavailability after SINCAPEG was 1.8-fold that of insulin solution administered SC. PD analysis showed that smaller areas under the effect curve and, conversely, larger areas above the effect curve were obtained after INCAPEG in comparison to insulin solution. The magnitude of this effect was increased after SINCAPEG. The presence of CAP-PEG particles appears to positively influence the disposition of insulin administered to the lungs of Sprague-Dawley rats. Spray instillation appears to be a more efficient method of delivering insulin to the lungs of rats than intratracheal instillation.
title: Imaging of spinal cord compression
Creators: name: Nicolás Liza, Lidia
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Pathology
subject: Diagnostic procedure
subject: MR
subject: CT
subject: Neuroradiology spine

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To review common and uncommon causes of spinal cord compression. To describe the radiological findings using CT and MRI, with emphasis in the...
A novel method for the determination of biliary clearance in humans
Creators: name: Heizer, William D.
name: Kowalsky, Richard J.
name: Brouwer, Kim L.R.
name: Ghibellini, Guilia
name: Johnson, Brendan M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: Biliary excretion is an important route of elimination and the biliary tract is a potential site of toxicity for many drugs and xenobiotics. Quantification of biliary excretion in healthy human volunteers is logistically challenging and is rarely defined during drug development. The current study uses a novel oroenteric tube coupled with a specialized clinical protocol to examine the pharmacokinetics of 99mTechnetium (Tc-99m) mebrofenin, a compound that undergoes rapid hepatic uptake and extensive biliary excretion. A custom-made multilumen oroenteric tube was positioned in the duodenum of healthy human volunteers. Subjects were positioned under a gamma camera and 2.5 mCi of Tc-99m mebrofenin was administered intravenously. Duodenal aspirates, blood samples, and urine were collected periodically for 3 hours. Two hours after Tc-99m mebrofenin administration, the gallbladder was contracted with an intravenous infusion of cholecystokinin-8. Gamma scintigraphy was used to determine the gallbladder ejection fraction in each subject. Total systemic clearance of Tc-99m mebrofenin approximated liver blood flow (Cl(total) 17.3 degrees 1.7 mL/min/kg), and 35% to 84% of the Tc-99m mebrofenin dose was recovered in bile. However, when the data were corrected for the gallbladder ejection fraction, 71% to 92% of the excreted Tc-99m mebrofenin dose was recovered. This novel oroenteric tube and clinical protocol provide a useful method to quantify biliary excretion of xenobiotics in healthy human volunteers.
Particle size analysis: AAPS workshop report, cosponsored by the Food and Drug Administration and the United States Pharmacopeia
Creators: name: Etzler, Frank
name: Hickey, Anthony J.
name: Duffy, Eric
name: Burgess, Diane J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: The concepts of particle engineering and dosage form design have become dominant themes in pharmaceutical manufacturing. This trend is not simply a reflection of the development of new, more sophisticated manufacturing methods of particles or dispersed systems but also recognition of the importance of quality control even in more traditional manufacturing processes. However, the diversity of particle treatments, methods of particle size analysis, expression and interpretation of data, and process applications results in complicated and sometimes confusing criteria for selection, adoption, or relevance of the available techniques.
The influence of formulation and spacer device on the in vitro performance of solution chlorofluorocarbon-free propellant-driven metered dose inhalers
Creators: name: Beck, Vance P.
name: Hickey, Anthony J.
name: Williams, Dennis
name: Smyth, Hugh D.C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: The purpose of this study was to evaluate the hypothesis that spacer devices have limited effect on the in vitro fine particle dose emitted from solution metered dose inhalers containing different proportions of HFA134a [1,1,1,2-tetrafluoroethane] propellant. Two solution formulations (80% and 97.5% wt/wt HFA134a) were tested across the actuator alone, actuator plus Aerochamber, and Ace holding chamber. Particle size distributions were determined using laser diffraction (LD) and cascade impaction (CI). Multimodal particle size distributions were identified using LD. CI analyses were characterized by a major mode located at ≈0.5 μm. The fine particle dose emitted from the inhaler spacer combinations containing 97.5% HFA134a was independent of the device setup used. Fine particle doses were influenced by spacer setup in 80% HFA134a formulations, indicating different plume dynamics of low vapor pressure formulations. Sampling inlet deposition was approximately O when spacer devices were used with either formulation. When spacers were not used, sampling inlet deposition was increased significantly. However, inlet deposition with the 97.5% HFA134a formulation was significantly less than that of the 80% HFA134a formulation (≈25% of emitted dose compared with 69% respectively). Thus, high propellant concentration formulations appear to have more robust in vitro performance. This is particularly important given the preponderance of poor patient compliance that is associated with spacer use. High propellant concentrations had the advantage of fine particle doses that were independent of the device setup and significantly lowered sampling inlet deposition when no spacer was used.
โฟโตอิเล็กโตรคะตะไลติกสำหรับผลิตออกซิเจนจากการแยกน้ำโดยใช้ขั้วไฟฟ้าแอโนดทังสเตนออกไซด์ที่เตรียมด้วยเทคนิคการจุ่มเคลือบ
Creators: name: ฟารุจน์ สุภนันทิน
Publisher: name: สถาบันวิจัยและพัฒนา มหาวิทยาลัยเทคโนโลราชมงคลธัญบุรี
Year: 2019
Subjects: โฟโตอิเล็กโตรคะตะไลติก
วิธีจุ่มเคลือบ
ขั้วไฟฟ้าทังสเตนออกไซด์

description: วารสารวิจัยมหาวิทยาลัยเทคโนโลราชมงคลธัญบุรี, 18, 1, 52-59
Liposomal dry powders as aerosols for pulmonary delivery of proteins
Creators: name: Hickey, Anthony J.
name: Lu, Dongmei
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: The purpose of this research was to develop liposomal dry powder aerosols for protein delivery. The delivery of stable protein formulations is essential for protein subunit vaccine delivery, which requires local delivery to macrophages in the lungs. β-Glucuronidase (GUS) was used as a model protein to evaluate dry powder liposomes as inhaled delivery vehicles. Dimyristoyl phosphatylcholine:cholesterol (7∶3) was selected as the liposome composition. The lyophilization of liposomes, micronization of the powders, aerosolization using a dry powder inhaler (DPI), and in vitro aerodynamic fine particle fraction upon collection in a twinstage liquid impinger were evaluated. After lyophilization and jet-milling, the total amount of GUS and its activity, representing encapsulation efficiency and stability, were evaluated. The GUS amount and activity were measured and compared with freshly-prepared liposomes in the presence of mannitol, 43% of initial GUS amount, 29% of GUS activity after lyophilization and 36% of GUS amount, 22% of activity after micronization were obtained. Emitted doses from dry powder inhaler were 53%, 58%, 66%, and 73% for liposome powder:mannitol carrier ratios of 1∶0, 1∶4, 1∶9, and 1∶19. Fifteen percent of the liposome particles were less than 6.4 μm in aerodynamic diameter. The results demonstrate that milled liposome powders containing protein molecules can be aerosolized effectively at a fixed flow rate. Influences of different cryoprotectants on lyophilization of protein liposome formulations are reported. The feasibility of using liposomal dry powder aerosols for protein delivery has been demonstrated but further optimization is required in the context of specific therapeutic proteins.
Formulation of a dry powder influenza vaccine for nasal delivery
Creators: name: Mikszta, John A.
name: Crowder, Timothy M.
name: Sullivan, Vincent J.
name: Garmise, Robert J.
name: Hickey, Anthony J.
name: Mar, Kevin
name: Hwang, C. Robin
name: Huang, Juan
name: Ferriter, Matthew
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: The purpose of this research was to prepare a dry powder vaccine formulation containing whole inactivated influenza virus (VIIV) and a mucoadhesive compound suitable for nasal delivery. Powders containing WIIV and either lactose or trehalose were produced by lyophilization. A micro-ball mill was used to reduce the lyophilized cake to sizes suitable for nasal delivery. Chitosan flakes were reduced in size using a cryo-milling technique. Milled powders were sieved between 45 and 125 μm aggregate sizes and characterized for particle size and distribution, morphology, and flow properties. Powders were blended in the micro-ball mill without the ball. Lyophilization followed by milling produced irregularly shaped, polydisperse particles with a median primary particle diameter of ≈21 μm and a yield of ≈37% of particles in the 45 to 125 μm particle size range. Flow properties of lactose and trehalose powders after lyophilization followed by milling and sieving were similar. Cryo-milling produced a small yield of particles in the desired size range (<10%). Lyophilization followed by milling and sieving produced particles suitable for nasal delivery with different physicochemical properties as a function of processing conditions and components of the formulation. Further optimization of particle size and morphology is required for these powders to be suitable for clinical evaluation.
Novel dry powder preparations of whole inactivated influenza virus for nasal vaccination
Creators: name: Hickey, Anthony J.
name: Staats, Herman F.
name: Garmise, Robert J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: The purpose of these studies was to enhance mucosal and systemic antibody production in response to increased local residence time of a whole inactivated influenza virus administered as a dry powder nasal vaccine formulation. Spray-freeze-drying (SFD) particles suitable for nasal delivery were characterized for physico-chemical properties and stability. Mucoadhesive compounds (MA) were characterized for their effects on nasal residence time of vaccine powders in rats compared with published in vitro data and elicited immune responses. SFD particles (D50=26.9µm) were spherical with a specific surface area of 1.25 m2/g. Thermal analysis indicated SFD powders were amorphous and demonstrated improved stability with respect to liquid formulations under various storage conditions. In vitro physico-chemical studies and in vivo scintigraphic imaging experiments indicated sodium alginate (SA) and carboxymethylcellulose-high molecular weight (CMC-HMW) powder formulations most significantly increased residence time in Brown Norway rats. Intramuscular delivery provided equivalent serum antibody titers to intranasal (IN) powder without MA, in the presence of CMC-HMW, SA, and hydroxypropyl methylcellulose (HPMC-HMW) after initial dosing and all formulations except IN powder with chitosan after boosting. IN liquid provided equivalent serum antibody titers to all IN powders after the initial vaccination and significantly greater serum antibody titers than IN powder with chitosan after boosting. Trends were consistent between residence time studies and immune response; however, no statistically significant differences between powder and liquid formulations were observed. It was concluded that enhanced serum and mucosal antibody responses were elicited by a dry powder nasal vaccine, specifically, administered in the presence of sodium alginate.
(101269) Anthony Herbert King
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Raman characterization and chemical imaging of biocolloidal self-assemblies, drug delivery systems, and pulmonary inhalation aerosols: A review
Creators: name: Mansour, Heidi M.
name: Hickey, Anthony J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: This review presents an introduction to Raman scattering and describes the various Raman spectroscopy, Raman microscopy, and chemical imaging techniques that have demonstrated utility in biocolloidal self-assemblies, pharmaceutical drug delivery systems, and pulmonary research applications. Recent Raman applications to pharmaceutical aerosols in the context of pulmonary inhalation aerosol delivery are discussed. The “molecular fingerprint” insight that Raman applications provide includes molecular structure, drug-carrier/excipient interactions, intramolecular and intermolecular bonding, surface structure, surface and interfacial interactions, and the functional groups involved therein. The molecular, surface, and interfacial properties that Raman characterization can provide are particularly important in respirable pharmaceutical powders, as these particles possess a higher surface-area-to-volume ratio; hence, understanding the nature of these solid surfaces can enable their manipulation and tailoring for functionality at the nanometer level for targeted pulmonary delivery and deposition. Moreover, Raman mapping of aerosols at the micro- and nanometer level of resolution is achievable with new, sophisticated, commercially available Raman microspectroscopy techniques. This noninvasive, highly versatile analytical and imaging technique exhibits vast potential for in vitro and in vivo molecular investigations of pulmonary aerosol delivery, lung deposition, and pulmonary cellular drug uptake and disposition in unfixed living pulmonary cells.
title: Radio-anatomy of congenital anomalies and normal variants of pancreatic duct and pancreas
Creators: name: Ouji, Rim
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Abdomen
subject: Anatomy
subject: Pancreas
subject: CT
subject: MR
subject: Normal variants
subject: Imaging sequences
subject: Congenital

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Understanding pancreatic development and the congenital anomalies and variants that result from alterations in normal development allows for better recognition of these anomalies at diagnostic imaging. The aim of this study is: ⇒To describe the...
(101265) Augustine Alma King
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Anatomical variants of superior and inferior vena cava
Creators: name: Posa, Alessandro
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Anatomy
subject: Veins / Vena cava
subject: Vascular
subject: CT
subject: Normal variants
subject: Education
subject: Epidemiology
subject: Arteriovenous malformations
subject: Congenital

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The purpose of this educational exhibit is: To make a brief review of embryonic development of the superior and inferior vena cava. To showtypicalCT findings of superior and inferior vena cava congenital anatomical...
Mukai flops and P-twists
Creators: name: Addington, N.
name: Donovan, W.
name: Meachan, C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics

description: Associated to a Mukai flop X ---> X' is on the one hand a sequence of equivalences D(X) -> D(X'), due to Kawamata and Namikawa, and on the other hand a sequence of autoequivalences of D(X), due to Huybrechts and Thomas. We work out a complete picture of the relationship between the two. We do the same for standard flops, relating Bondal and Orlov's derived equivalences to spherical twists, extending a well-known story for the Atiyah flop to higher dimensions.
description: 26 pages. Minor changes following referee's suggestions. This is an expanded version of the paper to appear in Crelle
title: Rare presentation of asthma complication with pneumorrhachis associated with pulmonary interstitial emphysema, pneumomediastinum and subcutaneous emphysema.
Creators: name: Nóbrega, Andre
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Thorax
subject: Respiratory system
subject: Emergency
subject: CT-High Resolution
subject: CT
subject: Complications
subject: Outcomes analysis
subject: Outcomes

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Explain the mechanism and describe a rare asthma complication involving pneumorrhachis associated pulmonary interstitial emphysema with pneumomediastinum and subcutaneous...
title: Imaging Findings of Breast Cancer in Women Before Age 40
Creators: name: Rossi, Carolina
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Breast
subject: Mammography
subject: Ultrasound
subject: MR
subject: Biopsy
subject: Diagnostic procedure
subject: Cancer

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The purpose of this exhibit is: Present a series of cases of malignant breast tumors in women before age 40, a non-target population for breast cancer screening. Demonstrate the imaging characteristics of these tumors at mammography, ultrasound and...
Initial Characterization of Micafungin Pulmonary Delivery via Two Different Nebulizers and Multivariate Data Analysis of Aerosol Mass Distribution Profiles
Creators: name: Shi, Shuai
name: Dodds Ashley, Elizabeth S.
name: Hickey, Anthony J.
name: Alexander, Barbara D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Pharmaceutical aerosols have been targeted to the lungs for the treatment of asthma and pulmonary infectious diseases successfully. Micafungin (Astellas Pharma US, Deerfield, IL, USA) has been shown to be an effective antifungal agent when administrated intravenously. Pulmonary delivery of micafungin has not previously been reported. In the present pilot study, we characterize the performance of two nebulizers and their potential for delivering micafungin to the lungs as well as the use of multivariate data analysis for mass distribution profile comparison. The concentration of micafungin sodium increased by 21% when delivered by the Acorn II nebulizer and by 20% when delivered by the LC Plus nebulizer, respectively, from the first to the second sampling period. The Acorn II nebulizer delivered a fine particle fraction FPF(5.8) (%<5.8 microm) of 92.5 +/- 0.8 and FPF(3.3) (%<3.3 microm) of 82.3 +/- 2.1 during the first sampling period. For the LC Plus nebulizer, FPF(5.8) was 92.3 +/- 0.1 and FPF(3.3) was 67.0 +/- 0.7 during the first sampling period. The mass median aerodynamic diameter (MMAD) increased from 1.67 +/- 0.05 to 1.77 +/- 0.04 mum (Acorn II nebulizer) and from 2.09 +/- 0.01 to 2.20 +/- 0.01 microm (Pari LC Plus nebulizer) from the first to the second sampling periods. These changes in MMAD were statistically significant by paired t test. Multivariate data analysis showed that this could be explained systematically by greater drug deposition on stages with larger cutoff sizes and reduced drug deposition on stages with smaller cutoff sizes rather than multimodal deposition or other anomalies in size distribution.
title: MRI ancillary findings on HCC diagnosis
Creators: name: Cruz, João
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Liver
subject: Abdomen
subject: Oncology
subject: MR
subject: Education
subject: Neoplasia
subject: Cirrhosis

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To recognize hemodynamic features that allow for Hepatocellular Carcinoma (HCC) to be confidently diagnosed. MRI has the greatest sensitivity and specificity for the diagnosis of HCC. To get familiar with and understand the accuracy of different MRI...
Mobile Design - Thematic Teaching Book (M-BAT) Based Augmented Reality To Improve Smooth Motor Ability Kindergarten Children especially TK Tunas Kekancan Mukti Semarang
Creators: name: Haryati, Yuli
name: Ismartoyo
name: Kurniasih, Eem
Publisher: name: Zenodo
Year: 2022
Subjects: APPI PT PGRI
PGRI
ICDESS2022
Mobile Design - Thematic Teaching Book
Augmented Reality

description: This material was presented in ACT +1 activities and International Conference on Digital Education and Social Science as a presenter
title: MRI of vertebral invasion by non small cell lung cancer: which sequences are useful?
Creators: name: Mihoubi Bouvier, Fadila
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Bones
subject: Thorax
subject: Oncology
subject: MR
subject: CT
subject: Imaging sequences
subject: Staging
subject: Cancer
subject: Tissue characterisation

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Learning objectives: to optimize apical tumor MRI protocol to find a MRI qualitative and quantitative semiology helping differentiate inflammatory from tumoral changes of vertebrae adjoining primary tumor Background Lung cancer remain the most...
(101267) Adolphus Frederick King
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Design Video Course Learning High School Mathematics with Flipped Classroom Model for Improving Students' Critical Thinking Ability
Creators: name: Nurmawati
name: Kurniasih, Eem
name: Ismartoyo
Publisher: name: Zenodo
Year: 2022
Subjects: APPI PT PGRI
PGRI
ICDESS2022
Design Video Course Learning
Mathematic
Flipped Classroom Model
Critical Thinking Ability

description: This material was presented in ACT +1 activities and International Conference on Digital Education and Social Science as a presenter