cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Violência e cinema: um olhar sobre o caso brasileiro hoje
Creators: name: Seligmann-Silva, Márcio
Publisher: name: Comunicação & Cultura
Year: 2008

description: O texto apresenta uma discussão sobre a apresentação da violência no cinema feito no Brasil nos últimos anos. Enfocando sobretudo Carandiru, de Hector Babenco (2003), e Tropa de Elite, de José Padilha (2007), o ensaio desenvolve uma discussão sobre a utilização do dispositivo trágico (sobretudo dos conceitos de medo, piedade e catarse) nestas obras. Ele discute também o significado de obras calcadas em um discurso politicamente correto (o caso do Carandiru) e as confronta com a proposta de Padilha de narrar seu filme a partir do capitão Nascimento, um membro de um batalhão das forças de elite da polícia. Tratando do modelo do western, o artigo pensa em outros gêneros nos quais a anomia da sociedade é abordada cinematograficamente, criando figuras fortes e violentas como meio de enfrentar este estado de suspensão da lei.
description: Comunicação & Cultura, n. 5 (2008): Mediatização da dor
Influence of Spray Drying Temperatures and Storage Conditions on Physical and Functional Properties of Dried Egg White
Creators: name: Wattinee Katekhong
name: Sanguansri Charoenrein
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: This study investigated the effect of the spray drying inlet temperature (140, 160 and 180°C) and storage conditions (temperature; 25 and 40°C and storage period; 1 and 2 months) on the physical and functional properties of dried egg white. The results showed that the three inlet temperatures did not affect the color of the spray-dried egg white (SDEW) after drying. However, all SDEW increased in yellow color after storage at 40°C. The % solubility of SDEW and gelling properties including gel hardness and water holding capacity of the gel samples were changed when the dried samples were stored, particularly for SDEW drying at 180°C. The changes in gelling properties of the SDEW were related to a decrease in the enthalpy of protein denaturation, an increase in exposed sulfhydryl (SH) contents, a decrease in the total SH contents and the occurrence of protein aggregation as show by the SDS-PAGE pattern.
Lost Highway, de David Lynch: na denegação da dor, a ancoragem da(s) narrativa(s)
Creators: name: Avelar, Mário
Publisher: name: Comunicação & Cultura
Year: 2008

description: Em Lost Highway, David Lynch recorre a um dos tópicos mais relevantes da cultura americana, a estrada, para realizar uma leitura irónica dessa mesma cultura. Devedora da psicologia lacaniana, a estrutura do filme sustenta um processo de fuga ao real e à responsabilidade ética do indivíduo. A dificuldade de leitura do filme e o mistério que o percorre são desmontados através de uma análise dos elementos que compõem aquela estrutura, como a sutura e a Moebius strip.
description: Comunicação & Cultura, n. 5 (2008): Mediatização da dor
Peach SNPs by sequencing 480 accessions
Creators: name: Li, Yong
Publisher: name: figshare
Year: 2017
Subjects: subject: 60408 Genomics
subject: FOS: Biological sciences
subject: Genetics

description: 1. Resequencing 480 peach accessions with > 5x depth.2. The accession included wild relatives, landraces, and improved cultivars.
2. SNP calling was performed using GATK HaplotypeCaller.3. SNP file was compressed in tar.bz2 format.
Helicobacter pylori infection: from standard to alternative treatment strategies
Creators: name: Sousa, Cláudia
name: Ferreira, Rute
name: Azevedo, Nuno F.
name: Oleastro, Mónica
name: Azeredo, Joana
name: Figueiredo, Ceu
name: Melo, Luís D. R.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Helicobacter pylori is the major component of the gastric microbiome of infected individuals and one of the aetiological factors of chronic gastritis, peptic ulcer disease and gastric cancer. The increasing resistance to antibiotics worldwide has made the treatment of H. pylori infection a challenge. As a way to overhaul the efficacy of currently used H. pylori antibiotic-based eradication therapies, alternative treatment strategies are being devised. These include probiotics and prebiotics as adjuvants in H. pylori treatment, antimicrobial peptides as alternatives to antibiotics, photodynamic therapy ingestible devices, microparticles and nanoparticles applied as drug delivery systems, vaccines, natural products, and phage therapy. This review provides an updated synopsis of these emerging H. pylori control strategies and discusses the advantages, hurdles, and challenges associated with their development and implementation. An effective human vaccine would be a major achievement although, until now, projects regarding vaccine development have failed or were discontinued. Numerous natural products have demonstrated anti-H. pylori activity, mostly in vitro, but further clinical studies are needed to fully disclose their role in H. pylori eradication. Finally, phage therapy has the potential to emerge as a valid alternative, but major challenges remain, namely the isolation of more H. pylori strictly virulent bacterio(phages).
Tuning Anti-Klein to Klein Tunneling in Bilayer Graphene
Creators: name: Du, Renjun
name: Liu, Ming-Hao
name: Mohrmann, Jens
name: Wu, Fan
name: Krupke, Ralph
name: Löhneysen, Hilbert v.
name: Richter, Klaus
name: Danneau, Romain
Publisher: name: Universität Regensburg
Year: 2018
Subjects: subject: 530 Physik

description: We show that in gapped bilayer graphene, quasiparticle tunneling and the corresponding Berry phase can be controlled such that they exhibit features of single-layer graphene such as Klein tunneling. The Berry phase is detected by a high-quality Fabry-Pérot interferometer based on bilayer graphene. By raising the Fermi energy of the charge carriers, we find that the Berry phase can be continuously tuned from 2π down to 0.68π in gapped bilayer graphene, in contrast to the constant Berry phase of 2π in pristine bilayer graphene. Particularly, we observe a Berry phase of π, the standard value for single-layer graphene. As the Berry phase decreases, the corresponding transmission probability of charge carriers at normal incidence clearly demonstrates a transition from anti-Klein tunneling to nearly perfect Klein tunneling.
Reflexões sobre a dor
Creators: name: Pires, Maria Laura Bettencourt
Publisher: name: Comunicação & Cultura
Year: 2008

description: O tema da dor tem sido tratado, ao longo do tempo, pelos mais variados escritores. Trata-se da resposta a uma perda pessoal e, embora centrada na reacção emocional, tem também dimensões físicas, sociais e comportamentais. Neste artigo, referem-se algumas reflexões sobre o tema, procurando diversificar as perspectivas de que é abordado. Mencionam-se autores tão diferentes como C. S. Lewis, que propõe uma solução possível para o problema da dor, que tanto tem angustiado filósofos de todas as religiões, ao afirmar que um mundo sem dor é logicamente impossível; Martha Nussbaum, que pensa que a vergonha e aversão causadas pelo castigo também se podem considerar como parte do conceito de dor; e Susan Sontag, com a sua visão do horror e do sofrimento causados pela guerra e da sua relação com o mundo das imagens. O artigo termina com alguns comentários finais sobre as perspectivas apresentadas e sobre o tema em geral.
description: Comunicação & Cultura, n. 5 (2008): Mediatização da dor
A catarse do fogo: a simbologia do fogo nos ecrãs da televisão
Creators: name: Ilharco, Fernando
Publisher: name: Comunicação & Cultura
Year: 2008

description: Centrando-se nos distúrbios de Novembro de 2005 em Paris, durante os quais foram queimados milhares de automóveis, este artigo propõe uma análise fenomenológica e semiótica do fogo nos ecrãs da televisão. Porque na terceira ordem de simulacro (Baudrillard, 2004/1981) o fogo na televisão é apenas informação, questionamo-nos sobre o que nos informam as chamas no ecrã? Hoje o fogo é tanto o símbolo que sempre foi, como um media para uma hiper-realidade ecranizada, contextualizada pela abundância de bens e pelo universo dos telemóveis, da MTV, da Internet e da publicidade. Neste artigo utilizamos algumas das noções desenvolvidas por Jean Baudrillard, como a troca simbólica e a sua interpretação de potlatch, e a concepção da catástrofe como defesa, para tentar mostrar como os fogos nos ecrãs da televisão são, simultaneamente, causa e consequência do regime hiper-real em que vivemos, bem como uma troca simbólica paradoxal que re-alimenta o enquadramento hiper-real da sociedade hiper-real do século xxi.
description: Comunicação & Cultura, n. 5 (2008): Mediatização da dor
Supplementary Material for: 68Gallium DOTANOC-PET Imaging in Lung Carcinoids: Impact on Patients' Management
Creators: name: Lamarca, A.
name: Pritchard, D.M.
name: Westwood, T.
name: Papaxoinis, G.
name: Nonaka, D.
name: Vinjamuri, S.
name: Valle, J.W.
name: Manoharan, P.
name: Mansoor, W.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Background:68Gallium DOTA-PET imaging is preferable to standard somatostatin receptor scintigraphy where available; however, its role in the management of lung carcinoid tumours (LC) remains unclear. Methods: All consecutive patients with histologically confirmed LC from two ENETS Centres of Excellence were identified retrospectively. The primary objective was to assess the impact of 68Ga-DOTANOC-PET on clinical management in patients with LC. Results: Of 166 patients screened, 46 were eligible: 52% female, median age 57 years (range 21-86); type of LC: diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (4%), typical (44%), atypical (35%), not reported (17%); stage: localised (63%), locally advanced (13%), and metastatic (17%) (7% unknown). A total of 47 68Ga-DOTANOCs were performed with the following rationale: LC diagnosis confirmation (4; 9%), primary tumour identification (2; 4%), post-surgical assessment (19; 40%), staging (patients with known LC present at time of 68Ga-DOTANOC) (19; 40%), and consideration of peptide receptor radionuclide therapy (3; 7%). Twenty-seven (57%) scans showed evidence of non-physiological uptake: median maximum standardised uptake value 7.2 (range 1.42-53). 68Ga-DOTANOC provided additional information in 37% (95% CI 22-51) of patients and impacted on management in 26% (95% CI 12-41); 9 patients (21%) were identified to have occult sites of metastases. Out of the 19 patients with post-surgical 68Ga-DOTANOC, 3 (16%) were identified to have distant metastases. There were no differences in the rate of practice changing 68Ga-DOTANOC results by type of LC (p value 0.5). Conclusions: Our results support the role of 68Ga-DOTANOC for optimising the management of patients with LC, including post-surgical re-staging due to the potential for identifying occult metastases.
Chromo-pharmacophores: photochromic diarylmaleimide inhibitors for sirtuins
Creators: name: Falenczyk, Carolin
name: Schiedel, M.
name: Karaman, B.
name: Rumpf, T.
name: Kuzmanovic, Natascha
name: Grotli, M.
name: Sippl, Wolfgang
name: Jung, M.
name: König, Burkhard
Publisher: name: Universität Regensburg
Year: 2014
Subjects: subject: 540 Chemie

description: Controlling the activity of sirtuins is of high biomedical relevance as the enzymes are involved in cancer, neurodegeneration and other diseases. Therefore structural elements of 3,4-bisindoylmaleimides (BIMs), which are known NAD+-dependent histone deacetylase (sirtuin) inhibitors, were merged with photochromic diarylmaleimides to yield photoswitchable enzyme inhibitors. The new inhibitors show excellent photophysical properties, are switchable even in polar solvents, and subtype selective against hSirt2. The inhibitory activity changes up to a factor of 22 for the two photoisomers and physiological properties can therefore be effectively toggled by irradiation with light of different wavelengths. Docking experiments using the enzyme crystal structure explain the observed activity changes based on the steric demand of the thiophene substitution and the rigidity of the molecular structure.
description: Open-Access-Komponente aus der Allianzlizenz
As dores de Filoctetes
Creators: name: Carvalho, Jorge Vaz De
Publisher: name: Comunicação & Cultura
Year: 2008

description: Filoctetes de Sófocles é o paradigma para avaliar a dor e sua representação estética. A função de educação moral da arte leva o século xviii alemão a discutir a expressão da dor: deve ser contida ou exteriorizada? A atitude pessoal varia segundo a resistência, circunstâncias, regras sociais, integração em referências culturais. A dor não consiste só nos sinais neurotransmitidos da lesão ao cérebro. Implica a totalidade do ser, nas suas tonalidades psicológicas, afectivas, morais, volitivas. Ela rompe o ritmo da existência, desfigura a identidade, desarticula o discurso. Intransferível, gera limitações. Prova singular, expõe a possibilidade universal de sofrer. Muda a compreensão da realidade. Suscita a questão ontológica essencial: o sentido do ser vivo consignado ao sofrimento e à aniquilação.
description: Comunicação & Cultura, n. 5 (2008): Mediatização da dor
A better use of the shoulders we stand on: meta-analyses in the history of education
Creators: name: Geiss, Michael
name: Westberg, Johannes
Publisher: name: Zurich University of Teacher Education
Year: 2024
Subjects: History of education
Meta-analysis
Secondary analysis
Systematic literature review
Methodology
Historical research
Research literature

description: This article argues that the potential of the vast amount of research, published each year in the history of education, remains untapped. Given the rapidly growing number of academic publications in the field, there is a need for research that is based on articles, chapters and monographs already published. While analyses of existing research publications are widely used in other academic disciplines, such approaches remain under-utilized in the history of education.The argument of this article is supported in three steps. Firstly, we distinguish between different forms of research using existing data and research publications, in particular secondary analyses, systematic literature reviews and meta-analyses. Due to the heterogeneous nature of research publications in educational history, this article argues for the method of qualitative meta-analysis. Secondly, we discuss the risks and methodological pitfalls of research using existing research publications, outlining possible areas of application and discuss examples of meta-analyses in educational history. Finally, the article explores the implications of an increased use of meta-analyses, especially for the editors of scientific journals.This article provides an introduction to the main features of meta-analysis as applied in history of education. By promoting qualitative meta-analyses as original research, we argue that journals could help ensure that the potential for vibrant and highly productive research in the history of education is fully realized.Despite that the use of published research is widely discussed in the behavioral and social sciences, there is a lack of reflection on how to use the knowledge produced in the history of education. By presenting qualitative meta-analysis, this article provides a starting point for such a discussion.
description: +repphzhbib2024F
Probing the protein–nanoparticle interface: the role of aromatic substitution pattern on affinity
Creators: name: Ekmekci, Zeynep
name: Saha, Krishnendu
name: Moyano, Daniel F.
name: Tonga, Gulen Yesilbag
name: Wang, Hao
name: Mout, Rubul
name: Rotello, Vincent M.
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Developmental Biology
Biological Sciences
Chemistry
Biotechnology
Molecular Biology
Biochemistry
Biophysics

description: A new class of cationic gold nanoparticles (NPs) has been synthesised bearing benzyl moieties featuring –NO2 and –OMe groups to investigate the regioisomeric control of aromatic NP–protein recognition. In general, NPs bearing electron-withdrawing groups demonstrated higher binding affinities towards green fluorescent protein (GFP) than NPs bearing electron-donating groups. Significantly, a ∼7.5- and ∼4.3-fold increase in binding with GFP was observed for –NO2 groups in meta-position and para-position, respectively, while ortho-substitution showed binding similar to the unsubstituted ring. These findings demonstrated that the NP–protein interaction can be controlled by tuning the spatial orientation and the relative electronic properties of the aromatic substituents. This improved biomolecular recognition provides opportunities for enhanced biosensing and functional protein delivery to the cells.
Cactus Yearbook, 1997
Creators: name: University Of Texas At Austin
Publisher: name: The University of Texas at Austin
Year: 1997
Subjects: yearbook
University of Texas at Austin

description: Contents: Calendar (p.8) -- Student Life (p.36) -- Academics (p.78) -- Student Leadership (p.116) -- Organizations (p.146) -- Athletics (p.192) -- Greeks (p.266) -- Classes (p.334) --Limelight (p.398)
Parents of Children with Autism who Blog: a Thematic Analysis
Creators: name: Thomson, Sarah
Publisher: name: University of Hertfordshire
Year: 2015
Subjects: autism
ASC
ASD
family
parent
blog
thematic analysis

description: This study used thematic analysis to investigate the blogs of parents of children diagnosed with an Autism Spectrum Condition, with a particular focus on themes that emerge when parents write about themselves, their child and their family relationships. The first stage of the study involved a broad analysis of the first six months of entries presented within eight blogs. Themes which emerged during this stage included ‘Coping’, ‘Searching for an explanation - Meaning making’ and ‘Sense of belonging vs not belonging’. The second stage of the study involved a deeper analysis of two of the eight blogs, used as case studies, which were selected due to differing on aspects of the themes found during the first stage of analysis. Themes which emerged from the second stage were a superordinate theme of ‘Searching for an explanation - Meaning making’, with subordinate themes of ‘Relationship with ASC’ and ‘Relationship with society’. There were only brief mentions of family relationships within the blogs, except the relationship with the child and it seemed that parents often made sense of their experiences through their relationship with ASC and their relationship with society. Many of the parents who blogged reported changes in their relationship with society due to feeling that others do not understand and a sense of not belonging. It seemed that blogging provided a sense of belonging and a way of being understood for these parents, as well as a source of information to help parents explore ASC and their relationship with ASC. The themes that emerged may provide important information for clinicians and the implications of the research findings are discussed. The limitations of the study are noted and there are suggestions for future research.
Governor Experiences of the Strategic Development Process of English Free Schools
Creators: name: Mason, Philip
Publisher: name: UH Research Archive
Year: 2016
Subjects: Free Schools
Strategic Development
Governance
Governors
Grounded Theory
Structural reform
Education policy

description: Free Schools entail increased involvement from civil society actors in the provision of State-funded education in England. The increased devolution of freedoms and responsibilities to these ‘self-governing’ schools is reflected in a significant range of strategic decisions made through the development process. These include decisions over such issues as religious character, social purpose, educational priorities and innovations in organisation. However, which factors influence the exercise of these strategic freedoms within local experiences of the strategic development processes remains unclear. Existing literature and media debate has predominantly focussed on justification for these structural reforms and their educational and social outcomes. In maintaining focus at the macroscopic level the link between policy and outcomes is assumed. Furthermore, discussion at this level may ignore important features of the provision within Free Schools at the local level. This study focusses on how the social experiences of governors provide an alternative narrative within the broader debate on structural reform. It presents empirical findings focused on the reported experiences from 21 governor interviews with those responsible for the development of three Free Schools. Analysis followed a grounded theory methodology in which theoretical sampling was influenced by a broader range of interview, survey and secondary data. Coding of the data revealed that the formation of the vision and purpose, diverse relationships, continuous reorganisation and the positioning of oneself relative to others were recurring themes in the experiences reported within and between the schools. In order to explain the diversity of experiences in relation to these themes three categories were developed, namely motivations, relating and power. Similarities and differences in motivations (including personal relationships, vested interests and subjective judgements), relations (including social groupings and experiences of specific interactions) and power (including its configuration, perpetuation and dynamism) were analysed across the participant accounts. Diverse and manifold motivations and relations emerge in complex responsive processes of relating through which tacit hierarchies, sub-group identities and individual interests emerge in the conduct of loosely defined roles. It is concluded that the freedoms to self-define expose governors to diverse social influences on development. The enduring influence of founding relationships challenges the capacity of governors to maintain the balance required of the critical friend role. Furthermore, the local reallocation of diverse value propositions in school provision does not guarantee the relevance of schools to their communities, or democratic accountability over public spending.
Searching for the Blob: Physical and biogeochemical characteristics of the North Pacific marine heat wave in ocean models
Creators: name: Dallmann, Allysa
Publisher: name: University Corporation for Atmospheric Research (UCAR)
Year: 2021

description: In July of 2013, a marine heat wave, a period of anomalously warm sea surface temperatures, emerged in the northeastern Pacific Ocean and lasted until June of 2016. This significant event, referred to as the North Pacific Blob, had a large influence on marine ecosystems across the North Pacific Ocean. While studies have examined the physical and ecological ramifications of the Blob using observations collected at sea, it is unknown whether state-of-the-art oceanographic models can reproduce this event. Here, we identified and described the physical and biogeochemical characteristics of the Blob using output from simulations of four models that were contributed to the 6th Coupled Model Intercomparison Project (CMIP6) Ocean Model Intercomparison Project Version 2 (OMIP2). During the Blob period in the Northeastern Pacific Ocean, OMIP2 models simulated anomalously warm sea surface temperatures (SSTs), anomalously low dissolved inorganic carbon (DIC) concentrations, and anomalously high saturation states for the mineral aragonite (𝛺aragonite), as compared to pre-Blob climatological conditions. These findings were consistent with observations of the surface ocean in the real world during this period, though the magnitude of the SST, DIC, and aragonite anomalies differed across different model structures. Our analysis revealed that the Blob influenced the physical and biogeochemical properties of the upper 100m of the ocean in each OMIP2 model. Our results suggest that ocean models are generally capable of capturing the physical and biogeochemical characteristics of marine heat waves and show how the Blob was associated with a temporary relief of ocean acidification, an ongoing environmental problem.
Cactus Yearbook, 1998
Creators: name: University Of Texas At Austin
Publisher: name: The University of Texas at Austin
Year: 1998
Subjects: yearbook
University of Texas at Austin

description: Contents: Student Life (p.16) -- Academics (p.58) -- Athletics (p.106) -- Student Leadership (p.188) -- Organizations (p.222) -- Greeks (p.270) -- Classes (p. 326) -- Limelight (p.398) -- Index (p.446)
Impedance Detection and Modeling of Chemotherapeutic Agents by a Cancer Cell-Based Biosensor
Creators: name: Liu, Qingjun
name: Lu, Yanli
name: Wang, Hua
name: Zhou, Jie
name: Zhang, Yongsheng
name: Li, Rong
name: Wang, Ping
name: Chen, Qunwei
name: Luo, Senbiao
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorised

description: Impedance detection on adherently growing cells by micro-electrodes provides useful analytical methods for cancer research. Colon adenocarcinoma is one of the most common types of gastrointestinal cancer. To improve the survival rate of colon adenocarcinoma patients, chemotherapy becomes more and more important among the standard clinical treatments. In this study, a cell based-biosensor was developed to determine the cytotoxicity of therapy medicines to colorectal cancer using the LS180 cell line. By analyzing the varying parameters in the membrane and cell nucleus in an impedance circuit model, the anticancer mechanisms of the drugs were deduced by impedance sensing. By real-time monitoring of the biosensor, time- and concentration- dependent impedance changes were detected under treatment medicines, such as oxaliplatin, 5-fluorouracil, and the more effective combination regimen. The cell-based biosensor combined with circuit modeling provides a promising approach for drug screening and developing new therapeutic regimens with anticancer medicines.
Rifles, Swords and Water Pistols: Circumstances in Which Action Becomes Influential in an Action-Irrelevant Categorisation Task
Creators: name: Shipp, Nicholas
Publisher: name: UH Research Archive
Year: 2018
Subjects: concepts
action
categorisation
similarity
context

description: An assumption in Cognitive Psychology, which has been challenged in recent years, is that the systems responsible for action and perception work independently of one another. These systems work together during conceptual tasks and research has demonstrated that action knowledge can influence performance even when the task is ‘action-irrelevant’ (Borghi, 2004; Borghi, Flumini, Natraj & Wheaton, 2012; Creem & Proffitt, 2001; Tucker & Ellis, 1998, 2001). However, participants in such tasks are often only asked to make simple category judgements, such as natural versus man made. The research reported in this thesis has shown that, under certain conditions, participants use action knowledge to make ‘complex’ category choices in an action-irrelevant task. The experimental work has predominantly used the forced-choice triad task to assess the circumstances under which participants categorise objects based on shared actions. The triads were designed with a target object and two choice objects matching on either shared actions (rifle + water pistol), shared taxonomic relations (rifle + sword), or both (orange + banana). The context in which the objects were presented was also manipulated so that the objects were either presented on a white background (context-lean) or being used by an agent (context-rich). Participants were most likely to select the choice object that shared both a taxonomic and an action demonstrating that action has an ‘additive’ effect in categorical decisions. Presenting the objects being used by an agent in a functional scenario increased the saliency of the shared actions between the stimuli, and participants were more likely to select the action choice. The subsequent experimental work reported in the thesis sought to eliminate potential confounding variables including perceptual features, object typicality and task instructions. What the experimental work presented here has demonstrated is that action can influence decisions on more complex categories, and judgments of similarity. The research has identified three main circumstances under which knowledge of action becomes influential in the triad task designed for the purpose of this research as follows: (i) when it is presented in conjunction with taxonomic information, (ii) when it is presented with a context, and (iii) when participants are first asked to physically interact with the objects.
Thermodynamic Driving Forces of Guest Confinement in a Photoswitchable Cage
Creators: name: Juber, Selina
name: Wingbermühle, Sebastian
name: Nuernberger, Patrick
name: Clever, Guido H.
name: Schäfer, Lars V.
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: 540 Chemie

description: Photoswitchable cages that confine small guest molecules inside their cavities offer a way to control the binding/unbinding process through irradiation with light of different wavelengths. However, a detailed characterization of the structural and thermodynamic consequences of photoswitching is very challenging to obtain by experiment alone. Thus, all-atom molecular dynamics (MD) simulations were carried out to gain insight into the relationship between structure and binding affinity. Binding free energies of the B12F122- guest were obtained for all photochemically accessible forms of a photoswitchable dithienylethene (DTE) based coordination cage. The MD simulations show that successive photo-induced closure of the four individual DTE ligands that form the cage gradually decreases the binding affinity. Closure of the first ligand already significantly lowers the unbinding barrier and the binding free energy, and therefore favours guest unbinding both kinetically and thermodynamically. Analysis of the different enthalpy contributions to the free energy shows that binding is enthalpically unfavourable and thus an entropy-driven process, in agreement with experimental data. Dissecting the enthalpy into the contributions from electrostatic, van der Waals, and bonded interactions in the force field shows that the unfavourable binding enthalpy is due to the bonded interactions being more favourable in the dissociated state, suggesting the presence of structural strain in the bound complex. Thus, the simulations provide microscopic explanations for the experimental findings and open a possible route towards the targeted design of switchable nanocontainers with modified binding properties.
Examining the contribution of dentate gyrus granule cells and ambiguity toward the stress response and behaviour of the rodent
Creators: name: Glover, Lucas
Publisher: name: figshare
Year: 2017
Subjects: subject: Neuroscience
subject: 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
subject: FOS: Psychology
subject: Neuroscience and Physiological Psychology

description: The hippocampus and adult-born neurons have been implicated in regulating the stress response and disambiguating conflicting goal-related information. How these functions interact to promote adaptive behaviour has not been investigated. In this thesis, hippocampal lesions or pharmaco-genetic ablation of adult neurogenesis in mice ('TK mice') was used to dissect this relationship. Hippocampal lesions or selectively ablating adult neurogenesis decreased defensive behaviours toward a partially reinforced fear conditioned cue ('ambiguous fear conditioning'). Conversely, these animals did not show these impairments when a cue reliably predicted a footshock ('reliable fear conditioning'). In TK mice, this same pattern of results was also seen in Fos expression levels in the dentate gyrus and CA3. In additional experiments, baseline novelty-suppressed feeding behaviour (latency to eat a familiar food) did not differ between genotypes. After reliable fear conditioning, TK mice took longer to eat the food, suggesting increased anxiodepressive-like behaviour. After ambiguous fear conditioning, however, TK showed quicker latencies to eat, suggesting decreased anxiodepressive-like behaviour, as compared to wildtype mice. Clamping corticosterone levels was used to determine its role in adaptive responding to prior stress. Preventing experience-induced increases in corticosterone did decrease the latency for wildtype mice to eat after ambiguous fear conditioning, whereas TK mice were unaffected. Finally, another set of experiments were designed to see if ambiguity would affect appetitive behaviour in a non-spatial T-maze task with conflicting goal responses. It was found that mice with hippocampal lesions, but not TK mice, tended to choose an arm associated with a large reward less often if the other arm contained a small reward, as compared to their respective control groups. Similarly, hippocampal-lesioned mice, but not TK mice, chose an arm that was always associated with the presence of a reward less often if the other arm ambiguously predicted a reward. All of the above results suggest that the hippocampus, especially adult-born neurons, is necessary to disambiguate salient conflicting memories that underlie goal responses and that this disambiguation biases goal-related behaviour in an adaptive manner.
Large-Scale Preparation of Long-Chain ADMET Synthons
Creators: name: F. Sauty, Nicolas
name: Li, Hong
name: Caire da Silva, Lucas
name: Wagener, Kenneth B.
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorised

description: We report a convenient process with minimal purification to produce large quantities of α,ω-alkenyl alcohols. These reagents are indispensable precursors in ADMET chemistry. Icos-19-en-1-ol, nonacos-28-en-1-ol, and octatriacont-37-en-1-ol were produced effortlessly in large quantities (up to 45 g in a single batch) from undec-10-en-1-ol. By extension of the method, any desired methylene run length in the ADMET precursor can be achieved.
Sensitivity to expression levels underlies differential dominance of a putative null allele of the Drosophila tβh gene in behavioral phenotypes
Creators: name: Damrau, Christine
name: Colomb, Julien
name: Brembs, Björn
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: 590 Tiere (Zoologie)

description: The biogenic amine octopamine (OA) and its precursor tyramine (TA) are involved in controlling a plethora of different physiological and behavioral processes. The tyramine-β-hydroxylase (tβh) gene encodes the enzyme catalyzing the last synthesis step from TA to OA. Here, we report differential dominance (from recessive to overdominant) of the putative null tβhnM18 allele in 2 behavioral measures in Buridan’s paradigm (walking speed and stripe deviation) and in proboscis extension (sugar sensitivity) in the fruit fly Drosophila melanogaster. The behavioral analysis of transgenic tβh expression experiments in mutant and wild-type flies as well as of OA and TA receptor mutants revealed a complex interaction of both aminergic systems. Our analysis suggests that the different neuronal networks responsible for the 3 phenotypes show differential sensitivity to tβh gene expression levels. The evidence suggests that this sensitivity is brought about by a TA/OA opponent system modulating the involved neuronal circuits. This conclusion has important implications for standard transgenic techniques commonly used in functional genetics.
Large Scale Preparation of Long Chain ADMET Synthons
Creators: name: F. Sauty, Nicolas
name: Li, Hong
name: Caire da Silva, Lucas
name: Wagener, Kenneth B.
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorised

description: We report a convenient process with minimal purification to produce large quantities of α, ω-alkenyl alcohols. These reagents are indispensable precursors in ADMET chemistry. Icos-19-en-1-ol, nonacos-28-en-1-ol, and octatriacont-37-en-1-ol were produced effortlessly in large quantities (up to 45 grams in a single batch) from undec-10-en-1-ol. By extension of the method, any desired methylene run length in the ADMET precursor can be achieved.
Evolutionary Targeted Discovery of Influenza A Virus Replication Inhibitors
Creators: name: Patel, Hershna
Publisher: name: UH Research Archive
Year: 2018
Subjects: Influenza
Virus
Conservation
Binding site
Protein
Docking

description: Influenza A is one of the most prevalent and significant viral infections worldwide, resulting in annual epidemics and occasional pandemics. Upon infection, antiviral drugs targeting the neuraminidase protein and M2 protein are the only treatment options available. However, the emergence of antiviral drug resistance is concerning, therefore the aim of this work was to identify inhibitor molecules that may bind to highly conserved regions of selected internal influenza A proteins. Sequences of the non-structural protein 1 (NS1), nuclear export protein (NEP) and polymerase basic protein 2 (PB2) from all hosts and subtypes were aligned and the degree of amino acid conservation was calculated based on Valdar’s scoring method. Missing parts of the experimental structures were predicted using the I-TASSER server and ligand binding hot spots were identified with computational solvent mapping. Selected binding sites in conserved regions were subjected to virtual screening against two compound libraries using AutoDock Vina and AutoDock 4. Two out of twelve top hit compounds predicted to target the NS1 protein showed capability of reducing influenza A H1N1 replication in plaque reduction assays at concentrations below 100 µM, although the target protein and mechanism of action could not be confirmed. For the NEP, conservation analysis was based on 3000 sequences and binding hot spots were located in common areas amongst three structures. Docking results revealed predicted binding affinities of up to -8.95 kcal/mol, and conserved amino acid residues interacting with top compounds include Arg42, Asp43, Lys39, Ile80, Gln101, Leu105, and Val109. For the PB2 protein, conservation analysis was based on ~12,000 sequences and fifteen potential binding hot spots were identified. Docking results revealed predicted binding affinities of up to -10.3 kcal/mol, with top molecules interacting with the highly conserved residues Gln138, Gly222, Ile539, Asn540, Gly541, Tyr531 and Thr530. The findings from this research could provide starting points for in vitro experiments, as well as the development of antiviral drugs that function to inhibit influenza A replication without leading to resistance.
How Blinking Affects Photon Correlations in Multichromophoric Nanoparticles
Creators: name: Schröder, Tim
name: Bange, Sebastian
name: Schedlbauer, Jakob
name: Steiner, Florian
name: Lupton, John M.
name: Tinnefeld, Philip
name: Vogelsang, Jan
Publisher: name: Universität Regensburg
Year: 2021
Subjects: subject: single-molecule spectroscopy, photon statistics, DNA origami structures, photophysics, quantum optics
subject: 530 Physik

description: A single chromophore can only emit a maximum of one single photon per excitation cycle. This limitation results in a phenomenon commonly referred to as photon antibunching (pAB). When multiple chromophores contribute to the fluorescence measured, the degree of pAB has been used as a metric to “count” the number of chromophores. But the fact that chromophores can switch randomly between bright and dark states, also impacts pAB and can lead to incorrect chromophore numbers being determined from pAB measurements. By both simulations and experiment, we demonstrate how pAB is affected by independent and collective chromophore blinking, enabling us to formulate universal guidelines for correct interpretation of pAB measurements. We use DNA-origami nanostructures to design multichromophoric model systems that exhibit either independent or collective chromophore blinking. Two approaches are presented that can distinguish experimentally between these two blinking mechanisms. The first one utilizes the different excitation intensity dependence on the blinking mechanisms. The second approach exploits the fact that collective blinking implies energy transfer to a quenching moiety, which is a time-dependent process. In pulsed-excitation experiments, the degree of collective blinking can therefore be altered by time gating the fluorescence photon stream, enabling us to extract the energy-transfer rate to a quencher. The ability to distinguish between different blinking mechanisms is valuable in materials science, such as for multichromophoric nanoparticles like conjugated-polymer chains, as well as in biophysics, e.g. for quantitative analysis of protein assemblies by counting chromophores.
title: Markov switching model και εφαρμογή στα oil & gaz
title: Markov switching model, oil and gaz
titleType: AlternativeTitle
Creators: name: Διαμαντόπουλος, Παναγιώτης
Publisher: name: Πανεπιστήμιο Πελοποννήσου
Year: 2022
Subjects: subject: Οικονομετρικά μοντέλα
subject: Χρηματοοικονομική
subject: Ενέργεια
subject: Αξιοποίηση πετρελαίου και αερίου
subject: Eκβιομηχάνιση
subject: Θεσμοί
subject: Καθεστώτα μεταγωγής Markov.
subject: Oil and gas exploitation
subject: Ιndustrialization
subject: Ιnstitutions
subject: Markov switching regime

description: Μ.Δ.Ε. 16
description: Συγκεκριμένα, ο στόχος αυτής της εργασίας είναι να αναδείξει ότι ένα Markov Switching Model είναι κατάλληλο για την εκτίμηση των τιμών των εμπορευμάτων. Για το σκοπό αυτό πραγματοποιήθηκε μία μελέτη όπου χρησιμοποιήθηκαν διάφορες εκδόσεις του Markov Switching Model καθώς και το μοντέλο γραμμικής παλινδρόμησης σε δεδομένα εμπορευμάτων. Αναλυτικά, χρησιμοποιήθηκαν εβδομαδιαία δεδομένα για δύο σημαντικά εμπορεύματα όπως είναι το πετρέλαιο και το φυσικό αέριο σε μια περίοδο 20 ετών (2000–2020), και πραγματοποιήθηκε εμπειρική ανάλυση. Για να γίνει σύγκριση μεταξύ των διαφόρων εκδόσεων των μοντέλων, χρησιμοποιήθηκε η προγνωστική ικανότητα του κάθε μοντέλου. Το τελικό αποτέλεσμα ανέδειξε ότι το Markov Switching Model δίνει καλύτερα αποτελέσματα από το αντίστοιχο μοντέλο γραμμικής παλινδρόμησης.
Storing NGS data: the good, the bad and the oligo
Creators: name: Addis, Matthew
Publisher: name: figshare
Year: 2017
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences
subject: 60408 Genomics
subject: FOS: Biological sciences

description: Short six minute presentation on the use of DNA for storing digital data as presented at the 7th Next Generation Sequencing Symposium, 17 May 2017, Southampton. The presentation reviews some of the work in the field including the techniques used for DNA data storage, the costs, the limitations and how DNA data storage compares with conventional IT solutions for long-term data archiving.
Relief en France métropolitaine et événements de courses a pied par region
Creators: name: Plard, Guichet
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2019

description: Source: https://www.nakala.fr/page/data/11280/4a43ea4c
description: Relation: https://www.nakala.fr/page/data/11280/4a43ea4c
description: dateCopyrighted: https://www.nakala.fr/data/11280/4a43ea4c
description: dateCopyrighted: https://www.nakala.fr/page/data/11280/d0ada45b
Metrics to Evaluate Human Teaching Engagement From a Robot's Point of View
Creators: name: Novanda, Ori
Publisher: name: UH Research Archive
Year: 2018
Subjects: robot teaching
engagement evaluation
effort measurement
human-robot interaction
humanoid robot
multimodal interaction
input modality preference

description: This thesis was motivated by a study of how robots can be taught by humans, with an emphasis on allowing persons without programming skills to teach robots. The focus of this thesis was to investigate what criteria could or should be used by a robot to evaluate whether a human teacher is (or potentially could be) a good teacher in robot learning by demonstration. In effect, choosing the teacher that can maximize the benefit to the robot using learning by imitation/demonstration. The study approached this topic by taking a technology snapshot in time to see if a representative example of research laboratory robot technology is capable of assessing teaching quality. With this snapshot, this study evaluated how humans observe teaching quality to attempt to establish measurement metrics that can be transferred as rules or algorithms that are beneficial from a robot’s point of view. To evaluate teaching quality, the study looked at the teacher-student relationship from a human-human interaction perspective. Two factors were considered important in defining a good teacher: engagement and immediacy. The study gathered more literature reviews relating to further detailed elements of engagement and immediacy. The study also tried to link physical effort as a possible metric that could be used to measure the level of engagement of the teachers. An investigatory experiment was conducted to evaluate which modality the participants prefer to employ in teaching a robot if the robot can be taught using voice, gesture demonstration, or physical manipulation. The findings from this experiment suggested that the participants appeared to have no preference in terms of human effort for completing the task. However, there was a significant difference in human enjoyment preferences of input modality and a marginal difference in the robot’s perceived ability to imitate. A main experiment was conducted to study the detailed elements that might be used by a robot in identifying a “good” teacher. The main experiment was conducted in two subexperiments. The first part recorded the teacher’s activities and the second part analysed how humans evaluate the perception of engagement when assessing another human teaching a robot. The results from the main experiment suggested that in human teaching of a robot (human-robot interaction), humans (the evaluators) also look for some immediacy cues that happen in human-human interaction for evaluating the engagement.