cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
On Algebraic Characterization of SSC of the Jahangir's Graph $\mathcal{J}_{n,m}$
Creators: name: Raza, Zahid
name: Kashif, Agha
name: Anwar, Imran
Publisher: name: arXiv
Year: 2017
Subjects: subject: Commutative Algebra (math.AC)
subject: FOS: Mathematics
subject: Primary 13P10, Secondary 13H10, 13F20, 13C14

description: In this paper, some algebraic and combinatorial characterizations of the spanning simplicial complex $Δ_s(\mathcal{J}_{n,m})$ of the Jahangir's graph $\mathcal{J}_{n,m}$ are explored. We show that $Δ_s(\mathcal{J}_{n,m})$ is pure, present the formula for $f$-vectors associated to it and hence deduce a recipe for computing the Hilbert series of the Face ring $k[Δ_s(\mathcal{J}_{n,m})]$. Finaly, we show that the face ring of $Δ_s(\mathcal{J}_{n,m})$ is Cohen-Macaulay and give some open scopes of the current work.
description: arXiv admin note: text overlap with arXiv:1509.04307
Additional file 6: of Disease evolution in mixed connective tissue disease: results from a long-term nationwide prospective cohort study
Creators: name: Reiseter, Silje
name: Gunnarsson, Ragnar
name: Corander, Jukka
name: Haydon, Joanna
name: Lund, May
name: Aaløkken, Trond
name: Taraldsrud, Eli
name: Hetlevik, Siri
name: Molberg, Øyvind
Publisher: name: figshare
Year: 2017
Subjects: subject: Medicine
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology

description: Univariable logistic regression analyses for remission at time point 2, “extended remission” and “durable remission”. (PDF 194 kb)
A Microfilament-Eruption Mechanism for Solar Spicules
Creators: name: Sterling, Alphonse C.
name: Moore, Ronald L.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Recent investigations indicate that solar coronal jets result from eruptions of small-scale chromospheric filaments, called minifilaments; that is, the jets are produced by scaled-down versions of typical-sized filament eruptions. We consider whether solar spicules might in turn be scaled-down versions of coronal jets, being driven by eruptions of "microfilaments." Assuming a microfilament's size is about a spicule's width ($\sim$300~km), the estimated occurrence number plotted against the estimated size of erupting filaments, minifilaments, and microfilaments approximately follows a power-law distribution (based on counts of CMEs, coronal jets, and spicules), suggesting that many or most spicules could result from microfilament eruptions. Observed spicule-base Ca II brightenings plausibly result from such microfilament eruptions. By analogy with coronal jets, microfilament eruptions might produce spicules with many of their observed characteristics, including smooth rise profiles, twisting motions, and EUV counterparts. The postulated microfilament eruptions are presumably eruptions of twisted-core micro magnetic bipoles that are $\sim$1$".0$ wide. These explosive bipoles might be built and destabilized by merging and cancelation of magnetic-flux elements of $\sim$few$\times 100$~G and of size
A new molecular mechanism of RNA circularization and the microRNA sponge formation
Creators: name: Belter, Agnieszka
name: Popenda, Mariusz
name: Sajek, Marcin
name: Woźniak, Tomasz
name: Naskręt-Barciszewska, Mirosława Z.
name: Szachniuk, Marta
name: Jurga, Stefan
name: Barciszewski, Jan
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Plant Biology
subject: 60506 Virology
subject: Computational Biology

description: A new mechanism of RNA circularization driven by specific binding of miRNAs is described. We identified the 71 CUUCC pentanucleotide motifs distributed regularly throughout the entire molecule of CDR1as RNA that bind to 71 miRNAs through their seed sequence GGAAG. The sequential binding of miR-7 RNAs (71 molecules) brings both ends of CDR1as RNA (1 molecule) together and stimulate phosphodiester bond formation between nucleotides C1 and A1299 at the 5’ and 3’ end, respectively. The binding of miRNAs to CDR1as RNA results in the unique complex formation, which shows three specific structural domains: (i) two short helixes with an internal loop, (ii) the hinge, and (iii) the triple-helix. The proposed mechanism explains specific RNA circularization and its function as a miRNAs sponge. Furthermore, the existing wet experimental data on the interaction of CDR1as RNA with miR-7 fully supports our observation. Although miR-671 shows the same seed sequence as miR-7, it forms an almost perfect double helix with CDR1as RNA and induces the cleavage of CDR1as, but does not stimulate circularization. To check how common is the proposed mechanism among circular RNAs, we analyzed the most recent circAtlas database counting almost 1.1 million sequences. It turned out that there are a huge number of circRNAs, which showed miRNAs seed binding sequences distributed through the whole circRNA sequences and prove that circularization of linear transcript is miRNA dependent. Communicated by Ramaswamy H. Sarma
In silico screening and molecular dynamics of phytochemicals from Indian cuisine against SARS-CoV-2 MPro
Creators: name: Rajendran, Mala
name: Roy, Sudeep
name: Ravichandran, Keerthana
name: Mishra, Bagdevi
name: Gupta, Deepak K.
name: Nagarajan, Subash
name: Selvaraj, Ruby Celsia Arul
name: Provaznik, Ivo
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: SARS-CoV-2 cause fatal infection in 213 countries accounting for the death of millions of people globally. In the present study, phytochemicals from spices were assessed for their ability to interact with SARS-CoV-2 MPro. Structure based virtual screening was performed with 146 phytochemicals from spices using Autodock Vina. Phytochemicals with binding energy ≥ −8.0 kcal/mol were selected to understand their interaction with MPro. Virtual screening was further validated by performing molecular docking to generate favorable docked poses and the participation of important amino acid residues. Molecular dynamics simulation for the docked poses was performed to study thermodynamic properties of the protein, ligand and protein-ligand complexes. The finding shows that cinnamtannin B2 and cyanin showed favorable binding affinity values with SARS-CoV-2 MPro. The results are comparable in terms of docked poses, important amino acid participation and thermodynamic properties with the standard control drugs remdesivir, benazepril and hydroxychloroquine diphosphate. Prime MM-GBSA was employed for end-point binding energy calculation. Binding to domain I and II of MPro were mediated through the OH, SH, NH2 and non-polar side chain of amino acids. Cinnamtannin B2 and cyanin binds to MPro with many sub sites within the active site with RMSD and RMSF within 4 Å. The results computed using Prime MM-GBSA show that cinnamtannin B2 (–68.54940214 kcal/mol) and cyanin (–62.1902835 kcal/mol) have better binding affinity in comparison to hydroxychloroquine diphosphate (–54.00912412 kcal/mol) and benazepril (–53.70242369 kcal/mol). The results provide a basis for exploiting cinnamtannin B2 and cyanin as a starting point potential candidate for the development of drug against SARS-CoV-2. Communicated by Ramaswamy H. Sarma
Development and validation of a model to preoperatively predict the risk of placenta accreta spectrum (PAS) in women with placenta previa
Creators: name: Wu, Suhui
Publisher: name: Zenodo
Year: 2024

description: Supplementary Table 1: Variance Inflation Factor for all the variables in the final prediction modelSupplementary Table 2: Cook’s distance for all the variables in the final prediction modelSupplementary Table 3: Verification of Test Assumptions in the final prediction model
The Aesthetics of Astrophysics: How to Make Appealing Color-Composite Images that Convey the Science
Creators: name: Rector, Travis A.
name: Levay, Zoltan G.
name: Frattare, Lisa M.
name: Arcand, Kimberly K.
name: Watzke, Megan
Publisher: name: arXiv
Year: 2017
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Astronomy has a rich tradition of using color photography and imaging, for visualization in research as well as for sharing scientific discoveries in formal and informal education settings (i.e., for "public outreach.") In the modern era, astronomical research has benefitted tremendously from electronic cameras that allow data and images to be generated and analyzed in a purely digital form with a level of precision not previously possible. Advances in image-processing software have also enabled color-composite images to be made in ways much more complex than with darkroom techniques, not only at optical wavelengths but across the electromagnetic spectrum. And the internet has made it possible to rapidly disseminate these images to eager audiences. Alongside these technological advances, there have been gains in understanding how to make images that are scientifically illustrative as well as aesthetically pleasing. Studies have also given insights on how the public interprets astronomical images, and how that can be different than professional astronomers. An understanding of these differences will help in the creation of images that are meaningful to both groups. In this invited review we discuss the techniques behind making color-composite images as well as examine the factors one should consider when doing so, whether for data visualization or public consumption. We also provide a brief history of astronomical imaging with a focus on the origins of the "modern era" during which distribution of high-quality astronomical images to the public is a part of nearly every professional observatory's public outreach. We review relevant research into the expectations and misconceptions that often affect the public's interpretation of these images.
description: Accepted, PASP, Invited Review for special focus issue concerning the topic of Data Visualization in Astronomy
Treatment efficacy of low-dose 5-fluorouracil with ultrasound in mediating 5-fluorouracil-loaded microbubble cavitation in head and neck cancer
Creators: name: Liao, Ai-Ho
name: Lee, Yu-An
name: Lin, Dao-Lung
name: Chuang, Ho-Chiao
name: Wang, Jehng-Kang
name: Chang, Ching-En
name: Li, Hsiang-Tzu
name: Wu, Ting-Yi
name: Shih, Cheng-Ping
name: Wang, Chih-Hung
name: Chu, Yueng-Hsiang
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: Over the past 50 years, 5-fluorouracil (5-FU) has played a critical role in the systemic chemotherapy of cancer patients. Bolus intravenous (IV) 5-FU infusion has been used due to the limitation of its extremely short half-life (10–15 min). This study used ultrasound (US) mediating 5-FU-loaded microbubbles (MBs) cavitation as a tool to increase local intratumoral 5-FU levels with a reduced dose of 5-FU (a single IV injection of 2.5 mg/kg instead of a single intraperitoneal injection of 25–200 mg/kg as used in previous studies in mice). The 5-FU-MBs were prepared with a 132 mg/mL albumin solution and a 0.30 mg/mL 5-FU solution. The diameters of the MBs and 5-FU-MBs were 1.24 ± 0.85 and 2.00 ± 0.53 µm (mean ± SEM), respectively, and the maximum loading efficiency of 5-FU on MBs was 19.04 ± 0.25%. In the in vitro study, the cell viabilities of 5-FU and 5-FU-MBs did not differ significantly, but compared with the 5-FU-MBs treatment-alone group, cell toxicity increased to 31% in the 5-FU-MBs + US group (p < 0.001). The biodistribution results indicated that the 5-FU levels of the tumors in small animals were significant higher for the 5-FU-MBs + US treatment than for either the 5-FU-MBs or 5-FU treatment with low 5-FU systemic treatment doses (2.5 mg/kg 5-FU IV). In small-animal treatment, 2.5 mg/kg 5-FU therapeutic IV doses injected into mice caused a more-significant reduction in tumor growth in the 5-FU-MBs + US group (65.9%) than in the control group after 34 days of treatment.
G protein-coupled estrogen receptor-1: homology modeling approaches and application in screening new GPER-1 modulators
Creators: name: Khan, Shafi Ullah
name: Ahemad, Nafees
name: Chuah, Lay-Hong
name: Naidu, Rakesh
name: Htar, Thet Thet
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Inorganic Chemistry
subject: Science Policy
subject: Plant Biology

description: G protein-coupled receptors (GPCRs) belong to the largest family of protein targets comprising over 800 members in which at least 500 members are the therapeutic targets. Among the GPCRs, G protein-coupled estrogen receptor-1 (GPER-1) has shown to have the ability in estrogen signaling. As GPER-1 plays a critical role in several physiological responses, GPER-1 has been considered as a potential therapeutic target to treat estrogen-based cancers and other non-communicable diseases. However, the progress in the understanding of GPER-1 structure and function is relatively slow due to the availability of a only a few selective GPER-1 modulators. As with many GPCRs, the X-ray crystal structure of GPER-1 is yet to be resolved and thus has led the researchers to search for new GPER-1 modulators using homology models of GPER-1. In this review, we aim to summarize various approaches used in the generation of GPER-1 homology model and their applications that have resulted in new GPER-1 ligands. Features and role of homology modeling in structure. Approaches to model structure. Application of the homology model for the identification of new ligand. Communicated by Ramaswamy H. Sarma
Additional file 1: of ATF3 inhibits the tumorigenesis and progression of hepatocellular carcinoma cells via upregulation of CYR61 expression
Creators: name: Chen, Cong
name: Ge, Chao
name: Liu, Zheng
name: Li, Liangyu
name: Zhao, Fangyu
name: Tian, Hua
name: Chen, Taoyang
name: Li, Hong
name: Yao, Ming
name: Li, Jinjun
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Table S1. Sequences of primers, probes and shRNA used for experiments in this study. Table S2. The antibodies for the Western blotting. Table S3. RNA-seq of differentially expressed genes in ATF3 overexpression SK-Hep1 cells. Table S4. RNA-seq of differentially expressed genes in ATF3 knockdown SMMC-7721 cells. Table S5. The antibodies for the IHC. Figure S1. The differential expression of ATF3 in HCC cell lines. Figure S2. ATF3 inhibited HCC cell proliferation in vitro by MTT assay. Figure S3. ATF3 suppressed HCC mobility in vitro. Figure S4. CYR61 suppressed HCC mobility in vitro. Figure S5. qRT-PCR analysis of the mRNA levels to confirm the differential expression of other genes identified from the ATF3 RNA-Seq results as targets of ATF3 in HCC cell lines with ATF3 overexpression or knockdown. (DOCX 3516 kb)
Turbulence modulation in heavy-loaded suspensions of tiny particles
Creators: name: Gualtieri, P.
name: Battista, F.
name: Casciola, C. M.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: The features of turbulence modulation produced by a heavy loaded suspension of small solid particles or liquid droplets are discussed by using a physically-based regularisation of particle-fluid interactions. The approach allows a robust description of the small scale properties of the system exploiting the convergence of the statistics with respect to the regularisation parameter. It is shown that sub-Kolmogorov particles/droplets modify the energy spectrum leading to a scaling law, $E(k)\propto k^{-4}$, that emerges at small scales where the particle forcing balances the viscous dissipation. This regime is confirmed by Direct Numerical Simulation data of a particle-laden statistically steady homogeneous shear flow, demonstrating the ability of the regularised model to capture the relevant small-scale physics. The energy budget in spectral space, extended to account for the inter-phase momentum exchange, highlights how the particle provide an energy sink in the production range that turns into a source at small scales. Overall, the dissipative fluid-particle interaction is found to stall the energy cascade processes typical of Newtonian turbulent flows. In terms of particle statistics, clustering at small scale is depleted, with potential consequences for collision models.
Properties of J-fusion frames in Krein space
Creators: name: Karmakar, Shibashis
name: Hossein, Sk. Monowar
name: Paul, Kallol
Publisher: name: arXiv
Year: 2016
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 42C15, 46C05, 46C20

description: In this paper we characterize $\sqrt{2}$-1-uniform $J$-Parseval fusion frames in a Krein space $\mathbb{K}$. We provide a few results regarding construction of new $J$-tight fusion frame from given $J$-tight fusion frames. We also characterize any uniformly $J$-definite subspace of a Krein space $\mathbb{K}$ in terms of a $J$-fusion frame inequality. Finally we generalize the fundamental identity of frames in Krein space $J$-fusion frame setting.
description: arXiv admin note: text overlap with arXiv:1611.01339
Comparative measurements of ITER Nb3Sn strands between two laboratories
Creators: name: Lu, J.
name: Hill, S.
name: McGuire, D.
name: Dellinger, K.
name: Nijhuis, A.
name: Wessel, W. A. J.
name: Krooshoop, H. J. G.
name: Chan, K.
name: Martovestky, N. N.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: ITER Nb3Sn strand quality verification tests require large quantities of precise measurements. Therefore regular cross-checking between testing laboratories is critically important. In this paper, we present results from a cross-checking test of 140 samples between the National High Magnetic Field Laboratory, USA and the University of Twente, the Netherlands. The tests comprise measurements at 4.2 K on critical current, RRR and hysteresis loss, while at room temperature the chromium layer thickness, Cu/nonCu ratio, filament twist pitch, and diameter were determined. Our results show very good agreement between the two labs. The reasons for small random discrepancies are discussed.
description: 5 figures
Rationalized design to explore the full potential of PLGA microspheres as drug delivery systems
Creators: name: Martinez-Borrajo, Rebeca
name: Diaz-Rodriguez, Patricia
name: Landin, Mariana
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology

description: Polymeric microparticles are widely used as drug delivery platforms either alone or embedded in more complex structures for regenerative medicine. Emulsion-solvent evaporation is the most extensively used technique for microparticles preparation. Despite the apparent simplicity of this method, there is no general procedure for producing microparticles of predictable characteristics (particle size, size distribution, encapsulation efficiency, and drug loading). Hybrid systems such as neurofuzzy logic allow identifying relationships between inputs and outputs, expressing the generated mathematical models through rules in linguistic format. In this work, the relationships between the variables involved in the emulsion-solvent evaporation process and the quality parameters of PLGA microparticles as drug delivery systems were established. Neurofuzzy logic software was able to generate models of high predictability (> 85%) for the microspheres properties namely particle size, size distribution, encapsulation efficiency and drug loading. Moreover, the generated sets of IF-THEN rules allowed to dictate general guidelines to better select the PLGA microparticles formulation parameters. This approach would be of great interest as a starting point to set-up protocols for the development of PLGA microparticles obtained by emulsion-solvent evaporation for many applications.
Additional file 5: of Disease evolution in mixed connective tissue disease: results from a long-term nationwide prospective cohort study
Creators: name: Reiseter, Silje
name: Gunnarsson, Ragnar
name: Corander, Jukka
name: Haydon, Joanna
name: Lund, May
name: Aaløkken, Trond
name: Taraldsrud, Eli
name: Hetlevik, Siri
name: Molberg, Øyvind
Publisher: name: figshare
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: Remission and medications in patients with mixed connective tissue disease, N = 104. Patients with SLEDAI-2 K = 0 and EUSTAR activity index ≥2.5 were first selected, then excluded if using medication not compatible with remission and finally sub grouped in remission on and off therapy. (PDF 128 kb)
Feasibility Study of Internal Conversion Electron Spectroscopy of $^{229m}$Th
Creators: name: Seiferle, Benedict
name: von der Wense, Lars
name: Thirolf, Peter G.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: With an expected energy of 7.8(5) eV, the isomeric first excited state in $^{229}$Th exhibits the lowest excitation energy of all known nuclei. Until today, a value for the excitation energy has been inferred only by indirect measurements. In this paper, we propose to use the internal conversion decay channel as a probe for the ground-state transition energy. MatLab-based Monte Carlo simulations have been performed to obtain an estimate of the expected statistics and to test the feasibility of the experiment. From the simulations we conclude, that with the presented methods an energy determination with a precision of better than 0.1 eV is possible.
description: 8 Pages, 5 Figures
title: ADCO, Huitième cartulaire de Saint-Étienne de Dijon (1661-1667), Cart. 31 (G 135), 549 folios, f. 0194
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire

description: Huitième cartulaire de Saint-Étienne de Dijon (1661-1667), Archives départementales de la Côte-d'Or, Cart. 31 (G 135), 549 folios, f. 0194, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Huitième cartulaire de Saint-Étienne de Dijon (1661-1667), Archives départementales de la Côte-d'Or, Cart. 31 (G 135), 549 folios, f. 0194, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Molecular evolution, binding site interpretation and functional divergence of aspartate semialdehyde dehydrogenase
Creators: name: Amala, Mathimaran
name: Richard, Mariadasse
name: Saritha, Poopandi
name: Prabhu, Dhamodharan
name: Veerapandiyan, Malaisamy
name: Surekha, Kangarajan
name: Jeyakanthan, Jeyaraman
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Aspartate Semialdehyde Dehydrogenase (ASDH) is an important enzyme essential for the viability of pathogenic microorganisms. ASDH is mainly involved in amino acid and cell wall biosynthesis of microorganisms, hence it is considered to be a promising target for drug design. This enzyme depicts similar mechanistic function in all microorganisms; although, the kinetic efficiency of an enzyme differs according to their active site residual composition. Therefore, understanding the residual variation and kinetic efficiency of the enzyme would pave new insights in structure-based drug discovery and a novel drug molecule against ASDH. Here, ASDH from Wolbachia endosymbiont of Brugia malayi is used as a prime enzyme to execute evolutionary studies. The phylogenetic analysis was opted to classify 400 sequences of ASDH enzymes based on their structure and electrostatic surfaces. Analysis resulted in 37 monophyletic clades of diverse pathogenic and non-pathogenic organisms. The representative structures of 37 ASDHs from different clades were further deciphered to structural homologues. These enzymes exhibited presence of more positively charged surfaces than negatively charged surfaces in the active site pocket which restrains evolutionary significance. Docking studies of NADP+ with 37 enzymes reveals that site-specific residual variation in the active site pocket modulates the binding affinity (ranges of −13 to −9 kcal/mol). Type-I and Type-II divergence studies show, no significant functional divergence among ASDH, but residual changes were found among the enzyme that modulates the biochemical characteristics and catalytic efficiency. The present study not only explores residual alteration and catalytic variability, it also aids in the design of species-specific inhibitors. Communicated by Ramaswamy H. Sarma
Magnus pairs in, and free conjugacy separability of, limit groups
Creators: name: Louder, Larsen
name: Touikan, Nicholas W. M.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Group Theory (math.GR)
subject: FOS: Mathematics
subject: 20F65, 20E05, 57M07

description: There are limit groups having non-conjugate elements whose images are conjugate in every free quotient. Towers over free groups are freely conjugacy separable.
description: 18 pages
Additional file 2: of A multiplex one-tube nested real time RT-PCR assay for simultaneous detection of respiratory syncytial virus, human rhinovirus and human metapneumovirus
Creators: name: Feng, Zhi-shan
name: Zhao, Li
name: Wang, Ji
name: Qiu, Fang-zhou
name: Zhao, Meng-chuan
name: Wang, Le
name: Duan, Su-xia
name: Zhang, Rui-qing
name: Chen, Chen
name: Qi, Ju-Ju
name: Fan, Tao
name: Li, Gui-xia
name: Ma, Xue-jun
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: The sequence results of HRV. (DOC 212 kb)
Drug repurposing for Alzheimer’s disease: in silico and in vitro investigation of FDA-approved drugs as acetylcholinesterase inhibitors
Creators: name: Kumar, Navneet
name: Gahlawat, Anuj
name: Kumar, Rajaram Naresh
name: Singh, Yash Pal
name: Modi, Gyan
name: Garg, Prabha
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: Alzheimer’s disease (AD) is one of the most familiar multifactorial and complex neurodegenerative disorders characterized by loss of cholinergic neurons in the brain. The various attempts for drug development to treat AD have been hampered by largely unsuccessful clinical trials in the last two decades. Developing a new drug from scratch takes enormous amounts of time, effort and money, mainly due to several barriers in the therapeutic drug development process. Drug repurposing strategy resuscitates this slow drug discovery process by finding new uses and clinical indications for existing drugs. This study is focused on the cholinergic hypothesis, a well-established target of the clinically available drugs in the market for the treatment of AD. The computational virtual screening (VS) led to the identification of thiazolidinedione (TZD, antidiabetic) and aminoquinoline (antimalarial) class of drugs as acetylcholinesterase (AChE) inhibitors. Intriguingly, rosiglitazone (RGZ) and hydroxychloroquine (HCQ) were found to be mild-to-moderate inhibitors of hAChE (human acetylcholinesterase) in our enzyme inhibition studies which are complementary to our computational studies. On the basis of our computational and experimental studies, it can be suggested that the beneficial effect of RGZ and HCQ in AD patients reported in the literature may partly be due to their AChE inhibitory property. The VS also led to the identification of antifungal drugs miconazole and oxiconazole as potential AChE inhibitors. The molecular dynamics (MD) simulation of the potential hits belonging to TZD, aminoquinoline and azoles class were also carried out. The MD simulations studies revealed detailed computational insights related to molecular interactions and protein–ligand stability for selected hits. Communicated by Ramaswamy H. Sarma
Materials for Chan & Chang (2019)
Creators: name: Chang, Charles B.
name: I Lei Chan
Publisher: name: OSF
Year: 2017
Subjects: Automatic Selective Perception
Chinese
Cumulative Enhancement Model
L2 Status Factor
L2 speech
Mandarin
Thai
Typological Primacy Model
Yoruba
bilingualism
crosslinguistic influence
language acquisition
language learning
language transfer
lexical tone
multilingualism
perceptual learning
speech perception
third language acquisition
tone

description: Test materials for Chan and Chang (2019, "Perception of nonnative tonal contrasts by Mandarin-English and English-Mandarin sequential bilinguals", JASA), which are shareable publicly according to the study's IRB protocol. The Language Background Questionnaire is provided below in PDF format; the LEXTALE_CH proficiency test is described in Chan and Chang (2018, "LEXTALE_CH: A quick, character-based proficiency test for Mandarin Chinese", Proceedings of BUCLD 42) and is accessible from https://osf.io/qdy4n/ in PDF format. The auditory stimuli used in the discrimination and rating tasks are not shareable for privacy reasons, but are reproducible with the information provided in the journal article.
Polysaccharide dextran-based conjugate for selective co-delivery of two synergistic drugs docetaxel and docosahexaenoic acid to tumor cells
Creators: name: Dong, Peng
name: Lv, Hongshuai
name: Jia, Weiping
name: Liu, Jiaojiao
name: Wang, Si
name: Li, Xiaohai
name: Hu, Jinghua
name: Zhao, Ling
name: Shi, Yikang
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer

description: Most chemotherapeutic agents are nonspecific distribution and cause systemic toxicities. Polysaccharide-based conjugates are promising strategies to overcome these drawbacks. To this end, two synergistic drugs docetaxel (DTX) and docosahexaenoic acid (DHA) were independently covalently bonded through individual linkers to dextran (100 kDa) to produce a novel dual-drug conjugate dextran–DHA–DTX. The single-drug conjugates dextran–DHA and dextran–DTX were also prepared for comparison. Fluorescent dye Cy7.5-based conjugates dextran–Cy7.5 and dextran–DHA–Cy7.5 were synthesized for cellular uptake study. The dual-drug conjugate dextran–DHA–DTX self-assembled into nanoparticles with the diameter of 102.3 ± 8.3 nm and demonstrated enhanced water solubility and improved pharmacokinetic profiles. Cellular uptake results showed that the dual-drug conjugate entered cells more than the parent DTX by determining the intracellular DTX contents via HPLC/MS analysis and by determining the fluorescent intensity of dextran-Cy7.5 and dextran–DHA–Cy7.5. Importantly, the dual-drug conjugate dextran–DHA–DTX significantly accumulated in tumor tissues and dramatically reduced the DTX concentrations in normal tissues. The dual-drug conjugate completely eradicated all the MCF-7 xenograft tumors without obvious side effects and showed more superior antitumor activity than parent DTX and single-drug conjugate dextran–DTX and dextran–DHA. Both in vitro and in vivo studies showed that DHA enhanced the antitumor activity of dextran–DTX. The polysaccharide dextran-based dual-drug conjugates may represent an effective way to improve the chemotherapeutic agents.
Aggregate dust particles at comet 67P/Churyumov-Gerasimenko
Creators: name: Bentley, Mark S.
name: Schmied, Roland
name: Mannel, Thurid
name: Torkar, Klaus
name: Jeszenszky, Harald
name: Romstedt, Jens
name: Levasseur-Regourd, Anny-Chantal
name: Weber, Iris
name: Jessberger, Elmar K.
name: Ehrenfreund, Pascale
name: Koeberl, Christian
name: Havnes, Ove
Publisher: name: arXiv
Year: 2017
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Comets are thought to preserve almost pristine dust particles, thus providing a unique sample of the properties of the early solar nebula. The microscopic properties of this dust played a key part in particle aggregation during the formation of the Solar System. Cometary dust was previously considered to comprise irregular, fluffy agglomerates on the basis of interpretations of remote observations in the visible and infrared and the study of chondritic porous interplanetary dust particles that were thought, but not proved, to originate in comets. Although the dust returned by an earlier mission has provided detailed mineralogy of particles from comet 81P/Wild, the fine-grained aggregate component was strongly modified during collection. Here we report in situ measurements of dust particles at comet 67P/Churyumov-Gerasimenko. The particles are aggregates of smaller, elongated grains, with structures at distinct sizes indicating hierarchical aggregation. Topographic images of selected dust particles with sizes of one micrometre to a few tens of micrometres show a variety of morphologies, including compact single grains and large porous aggregate particles, similar to chondritic porous interplanetary dust particles. The measured grain elongations are similar to the value inferred for interstellar dust and support the idea that such grains could represent a fraction of the building blocks of comets. In the subsequent growth phase, hierarchical agglomeration could be a dominant process and would produce aggregates that stick more easily at higher masses and velocities than homogeneous dust particles. The presence of hierarchical dust aggregates in the near-surface of the nucleus of comet 67P also provides a mechanism for lowering the tensile strength of the dust layer and aiding dust release.
title: Pot en céramique sigillée (Inv. 994.9.2632.5) – Oppidum de Bibracte
Creators: name: Bibracte
Publisher: name: Conservatoire National des Données 3D (CND3D)
Year: 2024
Subjects: subject: pot

description: Ce fragment de pot moulé présente l éclat rouge caractéristique des sigillées romaines  prisées par les élites éduennes qui adoptent  tant dans leurs objets quotidiens que dans leur cadre de vie  les usages romains.
Guanidine-modified albumin-MMAE conjugates with enhanced endocytosis ability
Creators: name: Yi, Ce
name: Xie, Fei
name: Xu, Xin
name: Xiao, Dian
name: Zhou, Xinbo
name: Cheng, Maosheng
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Aiming to address the insufficient endocytosis ability of traditional albumin drug conjugates, this paper reports elegant guanidine modification to improve efficacy for the first time. A series of modified albumin drug conjugates were designed and synthesized with different structures, including guanidine (GA), biguanides (BGA) and phenyl (BA), and different quantities of modifications. Then, the endocytosis ability and in vitro/vivo potency of albumin drug conjugates were systematically studied. Finally, a preferred conjugate A4 was screened, which contained 15 BGA modifications. Conjugate A4 maintains spatial stability similar to that of the unmodified conjugate AVM and could significantly enhance endocytosis ability (p*** = 0.0009) compared with the unmodified conjugate AVM. Additionally, the in vitro potency of conjugate A4 (EC50 = 71.78 nmol in SKOV3 cells) was greatly enhanced (approximately 4 times) compared with that of the unmodified conjugate AVM (EC50 = 286.00 nmol in SKOV3 cells). The in vivo efficacy of conjugate A4 completely eliminated 50% of tumors at 33 mg/kg, which was significantly better than the efficacy of conjugate AVM at the same dose (P** = 0.0026). In addition, theranostic albumin drug conjugate A8 was designed to intuitively realize drug release and maintain antitumor activity similar to conjugate A4. In summary, the guanidine modification strategy could provide new ideas for the development of new generational albumin drug conjugates.
Additional file 4: of Disease evolution in mixed connective tissue disease: results from a long-term nationwide prospective cohort study
Creators: name: Reiseter, Silje
name: Gunnarsson, Ragnar
name: Corander, Jukka
name: Haydon, Joanna
name: Lund, May
name: AalĂ¸Kken, Trond
name: Taraldsrud, Eli
name: Hetlevik, Siri
name: ĂYvind Molberg
Publisher: name: figshare
Year: 2017
Subjects: subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: EUSTAR activity index in 104 patients with MCTD at time point 1 and 2. (PDF 149Â kb)
Determination of potential inhibitors based on isatin derivatives against SARS-CoV-2 main protease (mpro): a molecular docking, molecular dynamics and structure-activity relationship studies
Creators: name: Badavath, Vishnu Nayak
name: Kumar, Akhil
name: Samanta, Pralok K.
name: Maji, Siddhartha
name: Das, Anik
name: Blum, Galia
name: Jha, Anjali
name: Sen, Anik
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: SARS-COV-2, the novel coronavirus and root of global pandemic COVID-19 caused a severe health threat throughout the world. Lack of specific treatments raised an effort to find potential inhibitors for the viral proteins. The recently invented crystal structure of SARS-CoV-2 main protease (Mpro) and its key role in viral replication; non-resemblance to any human protease makes it a perfect target for inhibitor research. This article reports a computer-aided drug design (CADD) approach for the screening of 118 compounds with 16 distinct heterocyclic moieties in comparison with 5 natural products and 7 repurposed drugs. Molecular docking analysis against Mpro protein were performed finding isatin linked with a oxidiazoles (A2 and A4) derivatives to have the best docking scores of −11.22 kcal/mol and −11.15 kcal/mol respectively. Structure-activity relationship studies showed a good comparison with a known active Mpro inhibitor and repurposed drug ebselen with an IC50 value of −0.67 μM. Molecular Dynamics (MD) simulations for 50 ns were performed for A2 and A4 supporting the stability of the two compounds within the binding pocket, largely at the S1, S2 and S4 domains with high binding energy suggesting their suitability as potential inhibitors of Mpro for SARS-CoV-2. Communicated by Ramaswamy H. Sarma
p38α MAP kinase inhibitors to overcome EGFR tertiary C797S point mutation associated with osimertinib in non-small cell lung cancer (NSCLC): emergence of fourth-generation EGFR inhibitor
Creators: name: Ahmad, Iqrar
name: Shaikh, Matin
name: Surana, Sanjay
name: Ghosh, Arabinda
name: Patel, Harun
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology

description: The third-generation EGFR (epidermal growth factor receptor) inhibitors selectively and irreversibly target EGFR-T790M and other activating EGFR mutations. Osimertinib is the only FDA-approved third-generation inhibitor, which has a good potency against the EGFR-T790M mutant with minimal toxicities and excellent selectivity for wild-type EGFR. EGFR tertiary Cys797 to Ser797 (C797S) point mutation emanate rapidly after the treatment of osimertinib, which is an undruggable mutation to all three existing generation drugs. Recently, trisubstituted imidazoles were reported based on an off-target hit of a p38α MAPK (mitogen-activated protein kinase) inhibitor as the fourth-generation EGFR-TKIs to overcome the C797S resistance by inhibiting the clinically relevant triple mutant kinase L858R/T790M/C797 EGFR. Here, we are reporting the clinical trial p38α MAPK kinase inhibitors SD-06, Amgen 16, RWJ67657 and SCIO-323 as L858R/T790M/C797S EGFR TK inhibitors to overcome the problem of drug resistance in non-small cell lung cancer (NSCLC). Communicated by Ramaswamy H. Sarma
Experimental measurement-device-independent quantum digital signatures
Creators: name: Roberts, G. L.
name: Lucamarini, M.
name: Yuan, Z. L.
name: Dynes, J. F.
name: Comandar, L. C.
name: Sharpe, A. W.
name: Shields, A. J.
name: Curty, M.
name: Puthoor, I. V.
name: Andersson, E.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We propose and experimentally implement a novel reconfigurable quantum key distribution (QKD) scheme, where the users can switch in real time between conventional QKD and the recently-introduced measurement-device-independent (MDI) QKD. Through this setup, we demonstrate the distribution of quantum keys between three remote parties connected by only two quantum channels, a previously unattempted task. Moreover, as a prominent application, we extract the first quantum digital signature (QDS) rates from a network that uses a measurement-device-independent link. In so doing, we introduce an efficient protocol to distil multiple signatures from the same block of data, thus reducing the statistical fluctuations in the sample and increasing the final QDS rate.
description: 7 pages, 4 figures, supplementary materials included as ancillary file
A PRODUÇÃO DE SUJEITOS DO DESEMPENHO E A VIOLÊNCIA DA POSITIVIDADE POR BYUNG-CHUL HAN
Creators: name: Yumara Lúcia Vasconcelos
Publisher: name: Zenodo
Year: 2022

description: RESUMO

 

Este ensaio tematizou a violência da positividade, invisível e recorrente nas relações de trabalho, parte da racionalidade neoliberal, pressuposto a partir do qual a argumentação foi constituída. A pesquisa, fundamentalmente bibliográfica e de lógica indutiva, sustentou a discussão e análise de sua ressonância na vida do trabalhador, ressaltando aspectos relevantes relacionados à dessubjetivação e transformação do sujeito. Conforme a argumentação apresentada, concluiu-se que o controle sobre a sociedade do trabalho e o processo de exploração têm sido estabelecidos em dimensões cada vez mais imateriais, simbólicas e existenciais. O mercado, por sua racionalidade neoliberal, tem adotado estratégias de poder engendradas não apenas controlar, mas para dessubjetivar, produzir novas subjetividades e explorar as subjetividades criadas. O sujeito de desempenho (mercantilizado) é fruto desse processo, que é destrutivo, profundamente violento, injusto, invasivo, adoecedor e ao mesmo tempo, cruel e criativo.  A sutilização da violência neoliberal da positividade, com feições notadamente docilizadas, resulta da programação cognitiva operada (de subjetivação contábil e financeira), parte essencial de sua racionalidade, transformando sujeitos dominados em opressores de si e objeto de consumo.

 

Palavras-chave: Violência da positividade. Sujeito de desempenho. Racionalidade neoliberal.
Additional file 3: of Disease evolution in mixed connective tissue disease: results from a long-term nationwide prospective cohort study
Creators: name: Reiseter, Silje
name: Gunnarsson, Ragnar
name: Corander, Jukka
name: Haydon, Joanna
name: Lund, May
name: Aaløkken, Trond
name: Taraldsrud, Eli
name: Hetlevik, Siri
name: Molberg, Øyvind
Publisher: name: figshare
Year: 2017
Subjects: subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: SLEDAI-2 K in 104 patients with MCTD at time point 1 and 2. (PDF 19 kb)