cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
sj-docx-1-tam-10.1177_17588359211039928 – Supplemental material for ALBI score and outcomes in patients with hepatocellular carcinoma: post hoc analysis of the randomized controlled trial KEYNOTE-240
Creators: name: Vogel, Arndt
name: Merle, Philippe
name: Verslype, Chris
name: Finn, Richard S.
name: Zhu, Andrew X.
name: Cheng, Ann-Lii
name: Chan, Stephen Lam
name: Yau, Thomas
name: Ryoo, Baek-Yeol
name: Knox, Jennifer
name: Daniele, Bruno
name: Qin, Shukui
name: Wei, Ziwen
name: Miteva, Yanna
name: Malhotra, Usha
name: Siegel, Abby B.
name: Kudo, Masatoshi
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 110203 Respiratory Diseases

description: Supplemental material, sj-docx-1-tam-10.1177_17588359211039928 for ALBI score and outcomes in patients with hepatocellular carcinoma: post hoc analysis of the randomized controlled trial KEYNOTE-240 by Arndt Vogel, Philippe Merle, Chris Verslype, Richard S. Finn, Andrew X. Zhu, Ann-Lii Cheng, Stephen Lam Chan, Thomas Yau, Baek-Yeol Ryoo, Jennifer Knox, Bruno Daniele, Shukui Qin, Ziwen Wei, Yanna Miteva, Usha Malhotra, Abby B. Siegel and Masatoshi Kudo in Therapeutic Advances in Medical Oncology
Giant Pigeon and Small Person: Prompting Visually Grounded Models about the Size of Objects
Creators: name: Zhang, Yi
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Computer vision
Natural language processing
Knowledge representation and reasoning

description: Empowering machines to understand our physical world should go beyond models with only natural language and models with only vision. Vision and language is a growing field of study that attempts to bridge the gap between natural language processing and computer vision communities by enabling models to learn visually grounded language. However, as an increasing number of pre-trained visual linguistic models focus on the alignment between visual regions and natural language, it is difficult to claim that these models capture certain properties of objects in their latent space, such as size. Inspired by recent trends in prompt learning, this study will design a prompt learning framework for two visual linguistic models, ViLBERT and ViLT, and use different manually crafted prompt templates to evaluate the consistency of performance of these models in comparing the size of objects. The results of this study showed that ViLT is more consistent in prediction accuracy for the given task with six pairs of objects under four prompt designs. However, the overall prediction accuracy is lower than the expectation on this object size comparison task; even the better model in this study, ViLT, has only 16 out of 24 cases better than the proposed random chance baseline. As this study is a preliminary study to explore the potential of pre-trained visual linguistic models on object size comparison, there are many directions for future work, such as investigating more models, choosing more object pairs, and trying different methods for feature engineering and prompt engineering.
Monkey Pox
Creators: name: Salman, Mohamad
name: Tahira Batool, Dr.
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 400603
subject: Molecular, biological, and multi-scale communications

description: This chapter gives MPXV [Monkeypox Outline], which emphasizes events in numerous regions and emphasizes interesting stocks that are much superior to Africa and Europe. This assessment is heightened with the least number of social statistics characteristics in this viral malady, appearing a huge number of cases between individuals between 25 and 34 years old, a time ancient. This statistical strategy emphasizes the craving for central intervention and instructive applications for companies with tall assignments. Insolvency emphasizes the most components of monkey metastasis, which comprises regions such as people, human, human, zone of creature tanks, such as rodents of positive sorts. The comes about control that indeed in case of natural disease is almost 30% of the case, most of the irresistible activity [around 60%] is closely related to contact. This emphasizes the interaction between natural components and open wellbeing administration, demonstrating the significance of effective perception and response strategies that coordinate the world's world control with activities for human physical quality. In expansion, discourse examines the significance of compelling campaigns in immunization and open discernments to ease the deployment of inability, particularly in intemperate opportunities. The ought to progress discourse and preparing within the field of open wellbeing is to pay attention to developing flare-ups with weight, adjustment to wellness frameworks and request for cautious consideration. Since at that point, the chapter presents the most zones of inquiry about the destiny of the long period, the socio-influenced populace, the socio-financial choice variables, and the worldwide security. Much obliged to the assistance of receiving intrigue approaches managing with energetic, natural and social complexes, partners can way better unravel issues related to the use of monkeys and progress the procedure of infection.
DIMENSIONAL PERSPECTIVES ON SERVICE QUALITY MODELS: AN OVERVIEW
Creators: name: John, Smith
name: Emily, Johnson
Publisher: name: Carson journal
Year: 2024
Subjects: Quality, Definition, Transcendent Approach, Product-Based Approach, User-Based Approach, Manufacturing-Based Approach, Value-Based Approach

description: Quality management is a fundamental concept that plays a crucial role in various fields, including manufacturing, economics, marketing, and operations management. This paper explores the multifaceted nature of quality by examining different approaches to its definition. Quality, as described by renowned scholars such as Juran, Crosby, and Garvin, is not a one-size-fits-all concept but rather a dynamic and context-dependent construct. The transcendent approach to quality, as proposed by Juran (1974), emphasizes "innate excellence." In this view, quality represents uncompromising standards and high achievement, discernible only through experience. It is an abstract concept that transcends specific criteria or measurements. Conversely, the product-based approach, as highlighted by Crosby (1979), considers quality as a "precise and measurable variable." It contends that variations in quality can be attributed to differences in the quantity of specific ingredients or attributes, often leading to higher costs associated with achieving superior quality. In the user-based approach, quality is intimately linked to customer satisfaction. This perspective, widely embraced in economics, marketing, and operations management, posits that the highest quality corresponds to the optimal satisfaction of consumer preferences. Thus, quality is measured by its ability to meet and exceed customer expectations. In contrast, the manufacturing-based approach defines quality as "making it right the first time." Rooted in supply chain management and engineering practices, this approach prioritizes error prevention and efficiency in production processes
sj-pdf-1-jpa-10.1177_07342829211047677 – Supplemental Material for Effects of Category Labeling With Emojis on Likert-Type Scales on the Psychometric Properties of Measurements
Creators: name: İlhan, Mustafa
name: Taşdelen Teker, Gülşen
name: Güler, Neşe
name: Ergenekon, Ömer
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Education
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental Material, sj-pdf-1-jpa-10.1177_07342829211047677 for Effects of Category Labeling With Emojis on Likert-Type Scales on the Psychometric Properties of Measurements by Mustafa İlhan, Gülşen Taşdelen Teker, Neşe Güler and Ömer Ergenekon in Journal of Psychoeducational Assessment
Additional file 1 of Identifying populations with chronic pain in primary care: developing an algorithm and logic rules applied to coded primary care diagnostic and medication data
Creators: name: Hafezparast, Nasrin
name: Bragan Turner, Ellie
name: Dunbar-Rees, Rupert
name: Vusirikala, Amoolya
name: Vodden, Alice
name: de La Morinière, Victoria
name: Yeo, Katy
name: Dodhia, Hiten
name: Durbaba, Stevo
name: Shetty, Siddesh
name: Ashworth, Mark
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1.
High temperature conjugated polymer transistors
Creators: name: Tran, Dung Trong
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Polymers and plastics
Macromolecular and materials chemistry not elsewhere classified

description: Organic semiconductors have been considered a promising candidate to replace Silicon-based inorganic semiconductors in our electronics due to their lightweight, high flexibility, and solution processability. Recently, conjugated polymers were shown to be functional at up to 200°C, expanding organic semiconductors application territory into high-temperature electronics, which sorely depends on wide-bandgap semiconductors. To push the operational temperature boundary of polymer transistors even further than 200°C, our understanding of temperature impacts on the materials and charge transport mechanism in such harsh conditions needs to be improved. Here, we study the high temperature effect on polymer transistors from two main directions: via molecular design and via device engineering. First, via sidechain design, we explored the impact of close π-π packing on the thermal stability of semiconducting polymers. We discovered that maintaining close π-π packing can lead to lower chain distortion, thus improving the polymer transistors' operational stability at high temperatures. Then we study the impact from device factor, specifically contact resistance in device behavior at extreme conditions. We found that the contact area is more susceptible to high temperatures than other regions in the channels and is the main reason for the degraded performance. We then propose a facile method to minimize the contact problem, to achieve stable devices at above 200°C. And last, we proposed a simple method to attain quasi-temperature independent charge transport in polymer transistors from room temperature to 140°C by simply applying a prolonged bias gate voltage before heating. This research expands our knowledge on charge transport in conjugated polymers at high temperatures and provides a guide to make conjugated polymer transistors for extreme conditions in the future.
Using Structural Regularities for a Procedural Reconstruction of Urban Environments from Satellite Imagery
Creators: name: Zhang, Xiaowei
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Computer graphics
Computer vision
Image processing
Modelling and simulation

description: Urban models are of growing importance today for urban and environmental planning, geographic information systems, urban simulations, and as content for entertainment applications. Various methods have addressed aerial or ground scale image-based and sensor-based reconstruction. However, few, if any, approaches have automatically produced urban models from satellite images due to difficulties of data noise, data sparsity, and data uncertainty. Our key observations are that many structures in urban areas exhibit regular properties, and a second or more satellite views for urban structures are usually available. Hence, we can overcome the aforementioned issues obtained from satellite imagery by synthesizing the underlying structure layout. In addition, recent advances in deep learning allow the development of novel algorithms that was not possible several years ago. We leverage relevant deep learning techniques for classifying/predicting urban structure parameters and modeling urban areas that address the problem of satellite data quality and uncertainty. In this dissertation, we present a machine learning-based procedural generation framework to automatically and quickly reconstruct urban areas by using regularities of urban structures (e.g., cities, buildings, facades, roofs, etc.) from satellite imagery, which can be applied to not only multiple resolutions ranging from low resolution (e.g., 3 meters) to high resolutions (e.g., WV3 0.3 meter) of satellite images but also the different scales (e.g., cities, blocks, parcels, buildings, facades) of urban environments. Our method is fully automatic and generates procedural structures in urban areas given satellite imagery. Experimental results show that our method outperforms previous state-of-the-art methods quantitatively and qualitatively for multiple datasets. Furthermore, by applying our framework to multiple urban structures, we demonstrate our approach can be generalized to various pattern types. We also have preliminary results applying this for flooding, archaeological sites, and more.
EXPLORING URANYL-OXO ACTIVATION VIA IMIDO SUBSTITUENTS AND EXPANDING THE LIBRARY OF URANIUM MULTIPLE IMIDO COMPLEXES
Creators: name: Collins, Tyler S
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Inorganic chemistry not elsewhere classified
F-block chemistry
Organometallic chemistry

description: Uranium imido complexes are highly sought after for their analogous nature to the uranyl moiety. Because of the highly reactive characteristics of uranium imido bonds compared to uranyl oxygen bonds these complexes have been used to investigate chemistry that can be used to activate the uranyl moiety. The activation of the trans-oxo groups of the uranyl moiety would open the door for the recycling of spent nuclear waste, diverting these chemicals from long term storage to a second life beyond nuclear fission. A suitable analog to the uranyl moiety has been discovered with the uranium bis(imido) family of complexes, these complexes can participate in chemistry that is similar if not, exactly the same as uranyl complexes. Studies with the uranium bis(imido) complex have been used to probe uranyl reactivity because the analogous nature of the two moieties. With that a uranium(IV) cis-bis(imido) complex was synthesized demonstrating how electron donation to the metal center can disrupt the Inverse Trans Influence (ITI) can as a result activate the trans-ligands on uranium. This complex is the first reported U(IV) bis(imido) with trans imido groups and achieved this geometry without large steric ligands to facilitate the cis- geometry. Computational analysis of this complex shows the stable nature of the geometry and how the fundamental electronics of this complex are the leading factor in the resultant geometry. When reactivity of the cis-bis(imido) was explored via protonation experiments a unique U(V) complex was isolated. Additional protonation reactivity was explored using UO2(tBubpy)(NTSA)2 with a variety of anilines to synthesize uranyl imido complexes. These experiments showed that the electronic environment—not the steric profile—of the anilines has a much greater effect on the stability of the resulting uranyl imido. The resulting uranyl imido complexes demonstrate the analogous nature of uranyl and uranium imido chemistry. Activation of the trans-imido groups on uranium bis(imido) complexes has also been shown with the synthesis of the uranium tris- and tetrakis(imido) complexes. These later complexes have shown that increased electron donation to the uranium metal center weakens and elongates the imido bonds, exposing these compounds to reactivity previously unavailable to uranium compounds with fewer multiply bound groups.
sj-docx-7-hpp-10.1177_15248399211046578 – Supplemental material for Collaborating With Student Parents as Participatory Researchers in a Qualitative Study
Creators: name: Rauh, Lauren
name: Manze, Meredith G.
name: Watnick, Dana
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: Sociology
subject: FOS: Sociology

description: Supplemental material, sj-docx-7-hpp-10.1177_15248399211046578 for Collaborating With Student Parents as Participatory Researchers in a Qualitative Study by Lauren Rauh, Meredith G. Manze and Dana Watnick in Health Promotion Practice
Perceiving Mindscapes: An Intellectual History of the Development of Landscape Architecture in France and the United States, 1852-1894
Creators: name: Powell, Samantha Caitlin Lozano
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Historical studies not elsewhere classified

description: “Perceiving Mindscapes: An Intellectual History of Transnational Development of Landscape Architecture in France and the United States, 1852-1894” traces the landscape architecture thought of several key individuals as their thoughts occurred in a network of park development between France and the United States. This study contributes to the history of parks, constructed or preserved, and their perceived impacts on humanity. Specifically, I examine the writings of Frederick Law Olmsted, Calvert Vaux, Adolphe Alphand, Édouard André, and Maurice de Vilmorin. All landscape architects and Vilmorin, a horticulturalist, wrote professing a proclivity to aiding city dwellers (directly or indirectly) by designing urban parks for recreational use. I contend that these landscape architects designed urban parks with their perceived notions of what city dwellers may have needed or wanted, without the ability of knowing or addressing these needs or wants. By tracking these designs internationally, I note how French and American landscape architects enabled one another to rapidly develop landscape architecture around the concepts of internal ailments, aesthetics, pragmatism, and longevity.
sj-docx-1-lis-10.1177_09610006211048004 – Supplemental material for A study of university law students’ self-perceived digital competences
Creators: name: Martzoukou, Konstantina
name: Kostagiolas, Petros
name: Lavranos, Charilaos
name: Lauterbach, Thorsten
name: Fulton, Crystal
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 89999 Information and Computing Sciences not elsewhere classified
subject: FOS: Computer and information sciences

description: Supplemental material, sj-docx-1-lis-10.1177_09610006211048004 for A study of university law students’ self-perceived digital competences by Konstantina Martzoukou, Petros Kostagiolas, Charilaos Lavranos, Thorsten Lauterbach and Crystal Fulton in Journal of Librarianship and Information Science
DEVELOPING IN-VITRO SYNTHETIC BLOOD CLOT MODELS FOR TESTING THROMBOLYTIC DRUGS
Creators: name: Zeng, Ziqian
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Biomedical engineering not elsewhere classified
Biomaterials

description: Thrombosis is the pathological formation of a blood clot in the body that blocks blood circulation, leading to high morbidity and mortality rates. Thrombolytic drugs that offer rapid clot dissolution are promising treatments yet current drugs are often associated with limited efficacy and high bleeding risks. While numerous animal thrombosis models have been developed for drug screening, the translation of therapeutic agents into and through clinical trials remains limited. This is largely due to animal models’ poor reproducibility and distinctive physiology to that of humans. In-vitro flow models that utilize both human blood components and physiologically relevant flow conditions can provide for a more representative testing environment to screen thrombolytic drugs. Developing better in-vitro models may not eliminate the need for preclinical animal testing but can help exclude inefficient agents earlier in the drug development pipeline to expedite the drug evaluation process. Existing in-vitro thrombolysis flow models are not ideal as they either adopt over-simplified clot substrates or utilize small-length-scale geometries that insufficiently mimic native hemodynamics. Thus, we propose to first develop a static fluorescently labeled clot lysis assay for an initial high throughput screening of thrombolytic drugs, and ultimately engineer a highly reproducible, physiological scale, flowing clot lysis model for more human relevant drug efficacy evaluation. Developing the static clot lysis assay not only helps to understand the mechanism of how diversified clotting conditions affect clot properties but also offer a chance to well-characterize fluorescence conjugations to fibrins. The ultimate flow model combines an in-vivo-like fluorescence incorporated synthetic clot (FISC) and a human-relevant flow system. Guided by results from static clotting experiments diversified FISCs are fluorescently optimized and fabricated dynamically using a Chandler loop setup at various conditions. The flow system is a tubing-based structure that comprises of a peristaltic pump, and a well-controlled flow chamber to provide for physiological shear and pulsatile levels. Therefore, the proposed synthetic clot model is a versatile platform that can mimic a variety of thrombosis conditions and offer representative drug testing and dosing results across numerous thrombolytic agents.
Investigating cellular functions of the SMARCAD1 gene in human MPNST cells by CRISPR-Cas13d knockdown
Creators: name: Han, Han
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Oncology and carcinogenesis not elsewhere classified
Biochemistry and cell biology not elsewhere classified

description: Malignant Peripheral Nerve Sheath Tumor (MPNST) is a form of soft tissue sarcoma arising from peripheral nerve sheath cells. Currently, there is no clinically available targeted therapy because the targetable essential driver genes in this tumor are largely unknown. SMARCAD1 (SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily A, containing DEAD/H box 1) has been identified as a new tumor suppressor of MPNSTs in zebrafish. Several studies have also linked SMARCAD1 with cancer development together. However, the cellular roles of SMARCAD1 in human MPNST cells remain unclear. To investigate DNA damage repair functions of SMARCAD1 in human MPNST, we created a doxycycline-inducible Schwannoma cell line by CRISPR-Cas13d, a newly developed mRNA knockdown method. I verified efficiently SMARCAD1 knockdown cell line by western blot. In addition, knockdown of SMARCAD1 inhibits Schwannoma cell proliferation and anchorage-independent growth. It is reported that SMARCAD1 is involved in DNA damage repair mechanisms. I confirmed that loss of SMARCAD1 expression compromises DNA damage repairing function in Schwannoma cells. This result was also verified in two zebrafish smarcad1 mutants. In summary, I utilized a novel gene knockdown approach to generate a SMARCAD1 Schwannoma cell line and validated its function in DNA damage repair. This study might provide information for developing a new treatment option for MPNSTs.
Additional file 6 of ALPL regulates pro-angiogenic capacity of mesenchymal stem cells through ATP-P2X7 axis controlled exosomes secretion
Creators: name: Dong, Jiayi
name: Zhao, Wanmin
name: Zhao, Jiangdong
name: Chen, Ji
name: Liu, Ping
name: Zheng, Xueni
name: Li, Dehua
name: Xue, Yang
name: Zhou, Hongzhi
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Supplementary Material 6
MPEC 2025-F103 : 2025 FN4
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2025
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2025 FN4

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Site-Relevant Art: Post 20th Century Considerations of Site Specificity
Creators: name: Guerin, Johanna
Publisher: name: University of Southern Queensland
Year: 2023
Subjects: Site-specific
Conceptual
Contemporary
Visual art
Post 20th Century
Site-relevant

description: Historically, Site-specific art has been understood as a form of practice that challenges the notion of autonomy (or the separation of the object from the site) in which it is located, emphasising the interdependence of object and site. Towards the end of the 20th century, this interdependence began to expand to include the artist, artwork, site, and audience more overtly. These relationships reflect the human need for groundedness, to create a sense of belonging during times of upheaval; and the effects of capitalism, globalisation, and migration, forced or otherwise. If art is a commentary on society, then Site-specific art reflects a societal need for stability, to retain the identity of individuals and communities. As such, the identity of Site-specific art needs to be retained, while other works that do not generate the inherent relationship between artists, artwork, site, and audience, are identified in terms that better define what they are. The purpose of this research is to propose new considerations of the relationship of artist with site as a means of preserving the integrity of Site-specific art, but also, as will be argued, through the introduction of my term ’Site-relevant’,1 to capture works that exceed the limitations placed on our understanding of site. The original term that I offer to the discourse, ‘Site-relevant’, is intended to capture artworks that have a relationship with a specific site, outside of the ideal gallery space. These Site-relevant works can be relocated without compromising the artwork or conceptual intent.

This PhD is accompanied by two Site-specific artworks, and two Site-relevant artworks. I have made these works as a response to the research regarding the misapplication and overuse of the term ‘Site-specific’ in the discourse related to site-based artwork. I do not seek to ignore or deny the conceptual and historical significance of Site-specific works, or the contribution of other site-based artworks. Rather, my term ‘Site-relevant’ is intended to be an additional classification to the post 20th century discourse of installation art practice which aims to better describe artworks that are miscategorised as Site-specific.
sj-pdf-1-pmj-10.1177_0269216319833588 – Supplemental material for Symptoms and anxiety predict declining health-related quality of life in multiple myeloma: A prospective, multi-centre longitudinal study
Creators: name: Porta-Sales, Josep
name: Noble, Simon
name: Ramsenthaler, Christina
name: Gao, Wei
name: Siegert, Richard J
name: Edmonds, Polly M
name: Schey, Stephen A
name: Higginson, Irene J
Publisher: name: SAGE Journals
Year: 2021
Subjects: Geriatrics and Gerontology
Aged Health Care

description: Supplemental material, sj-pdf-1-pmj-10.1177_0269216319833588 for Symptoms and anxiety predict declining health-related quality of life in multiple myeloma: A prospective, multi-centre longitudinal study by Josep Porta-Sales, Simon Noble, Christina Ramsenthaler, Wei Gao, Richard J Siegert, Polly M Edmonds, Stephen A Schey and Irene J Higginson in Palliative Medicine
sj-docx-3-pie-10.1177_09544089211045907 - Supplemental material for Numerical modelling of activation energy and hydromagnetic non-Newtonian fluid particle deposition flow in a rotating disc
Creators: name: Babu, B. Hari
name: Rao, P. Srinivasa
name: Reddy, M. Gnaneswara
name: Varma, S.V.K.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies
subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, sj-docx-3-pie-10.1177_09544089211045907 for Numerical modelling of activation energy and hydromagnetic non-Newtonian fluid particle deposition flow in a rotating disc by B. Hari Babu, P. Srinivasa Rao, M. Gnaneswara Reddy and S.V.K. Varma in Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering
Analysis on Separated Regions in Internal Flows through Particle Image Velocimetry
Creators: name: Jr., John Charles Paulson
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Mechanical engineering not elsewhere classified

description: For internal flows, the detachment of the boundary layer is a major contributor to pressure loss. To improve efficiency, it is essential to characterize these regions to understand the location and magnitude. Particle Image Velocimetry (PIV) is applied to provide time-resolved measurements to achieve accurate results without perturbing the flow. This thesis covers the methodology for creating an adaptable optical measurement technique in a high frequency study of separated regions in transonic internal flows. Focus on the optimization of the laser optical array and image acquisition system yield improved Dynamic Spatial Range (DSR) and Dynamic Velocity Range (DVR). Further analysis is provided on the flow dynamics of the seed particle, with local seeding solutions provided for improved seeding density in high-speed flows for various geometries. Light scattering efficiency of the particle is also analyzed to completely define the desired particle size. Two pulse-burst Nd:YAG lasers and two high speed cameras are used in this study to achieve a frame straddling technique necessary to resolve high frequency flows. Comparison of the recording media to the DSR highlights performance costs and benefits between the two cameras. Uncertainty measurements are determined from the calculated setup and compared to correlation statistics-based uncertainty quantifications. Image processing and cross-correlation software are used to provide analysis on the flow characteristics for two separate studies with comparison to Computational Fluid Dynamic predictions.
A POTENT PYRAZOLE-CONTAINING STING ANTAGONIST SYNTHESIZED VIA DOEBNER-POVAROV MULTICOMPONENT REACTION
Creators: name: Ong, Wei Shiuan Wilson
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Medicinal and biomolecular chemistry not elsewhere classified
Organic chemistry not elsewhere classified
Biochemistry and cell biology not elsewhere classified

description: The cGAS-STING axis represents a key pathway towards the activation of innate immunity against pathogens. However, persistent activation can lead to the development of autoimmune diseases, driving the need for the development of antagonists of cGAS-STING pathway. Herein, we describe the discovery of a small molecule STING binder HSD1077 through a STING based fluorescence polarization (FP) displacement assay. Initial SAR studies utilizing the FP displacement assay suggests the presence of pyrazole moieties critical for HSD1077 towards STING Binding. Additionally, we show that HSD1077 serves as an antagonist of the cGAS-STING pathway and effectively suppresses type-1 interferon expression upon 2’-3’cGAMP induction in both murine RAW macrophages and human THP-1 monocytes. HSD1077 in conclusion shows potential as a lead compound towards the further development of anti-inflammatory drugs.
METHODS AND ANALYSIS OF MULTIPHASE FLOW AND INTERFACIAL PHENOMENA IN MEDICAL DEVICES
Creators: name: Eshraghi, Javad
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Mechanical engineering not elsewhere classified
Biomechanical engineering
Medical devices

description: Cavitation, liquid slosh, and splashes are ubiquitous in science and engineering. However, these phenomena are not fully understood. Yet to date, we do not understand when or why sometimes the splash seals, and other times does not. Regarding cavitation, a high temporal resolution method is needed to characterize this phenomenon. The low temporal resolution of experimental data suggests a model-based analysis of this problem. However, high-fidelity models are not always available, and even for these models, the sensitivity of the model outputs to the initial input parameters makes this method less reliable since some initial inputs are not experimentally measurable. As for sloshing, the air-liquid interface area and hydrodynamic stress for the liquid slosh inside a confined accelerating cylinder have not been experimentally measured due to the challenges for direct measurement.
ROAD SAFETY: A SHARED RESPONSIBILITY
Creators: name: A.F.Rajapov1 Department of Road Management of the Ministry of  Transport of the Republic of Uzbekistan
Publisher: name: Zenodo
Year: 2024

description: Road safety is a critical public health issue with devastating consequences. This article, structured in IMRAD format (Introduction, Methods, Results, Analysis, Discussion), explores the key factors contributing to road accidents and highlights the importance of a multi-faceted approach to improve road safety for all users.
Additional file 1 of Paternal preconception modifiable risk factors for adverse pregnancy and offspring outcomes: a review of contemporary evidence from observational studies
Creators: name: Carter, Tristan
name: Schoenaker, Danielle
name: Adams, Jon
name: Steel, Amie
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1.
ANALYZING WEATHER OBSERVATION DATA TO IMPROVE EMERGENCY SERVICES PILOT RISK ASSESSMENT IN MARGINAL WEATHER CONDITIONS
Creators: name: Houghton, Nicholas Michael
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Aerospace engineering not elsewhere classified

description: Emergency services (ES) pilots operate in a dynamic, high-risk team environment, as a subset of general aviation (GA) operations. The time constraints associated with ES operations means that ES pilots must make flight decisions quickly and often with limited or incomplete information (Worm, 1999). Due to the nature of ES operations, the consequences of an incorrect flight decision can be severe, including loss of life. ES operations are often initiated by extreme weather events, and ES pilots are frequently required to fly on the boundary between marginal visual flight rules (MVFR) weather conditions and instrument meteorological conditions (IMC). Unfortunately, an unintended transition into IMC is the leading cause of fatal accidents in GA operations (Ayiei et al., 2020). Mission objectives dictate that most ES pilots fly below 1,500’ above ground level (AGL) for extended periods of time, and low-altitude flight in hazardous weather can reduce a pilot’s outside visual reference, thus leading to spatial disorientation, loss of control, or controlled flight into terrain. To mitigate this problem, ES pilots must be able to accurately assess weather conditions before and during flight. However, the current method of presenting meteorological aerodrome reports (METARs) on weather displays can be misleading to pilots. Weather conditions in the areas between weather observation stations can be different than what is reported by the METAR observations at those stations. This can cause current or forecasted weather conditions between weather stations to be incompletely represented. However, pilots are given no obvious indication of how incompletely represented weather conditions can affect weather-related risk. This research demonstrates that a Kth Nearest Neighbor (KNN) analysis can be used to identify areas where the variability of conditions between weather stations (and thus weather-related risk) is incompletely represented by METAR observations. In addition, it is shown that areas where there is an increased risk of an unintended transition from MVFR to IMC can be identified among areas with incompletely represented conditions and depicted to pilots on aviation weather displays. Machine learning tactics are proposed as a way to consider additional inputs in future KNN analyses, and several emerging technologies are proposed as mediums to collect additional weather observations. The ability for an ES pilot to more accurately assess weather-related risk in MVFR conditions using the proposed technologies is evaluated, the benefits to ES pilots and the GA community are discussed, and the requirements and limitations of the study are examined.
sj-docx-1-mmr-10.1177_15586898211037412 – Supplemental material for Weight of Evidence: Participatory Methods and Bayesian Updating to Contextualize Evidence Synthesis in Stakeholders’ Knowledge
Creators: name: Dion, Anna
name: Carini-Gutierrez, Alessandro
name: Jimenez, Vania
name: Ben Ameur, Amal
name: Robert, Emilie
name: Joseph, Lawrence
name: Andersson, Neil
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, sj-docx-1-mmr-10.1177_15586898211037412 for Weight of Evidence: Participatory Methods and Bayesian Updating to Contextualize Evidence Synthesis in Stakeholders’ Knowledge by Anna Dion, Alessandro Carini-Gutierrez, Vania Jimenez, Amal Ben Ameur, Emilie Robert, Lawrence Joseph and Neil Andersson in Journal of Mixed Methods Research
מדריכים לכלים דיגיטליים ופתרונות בחקלאות מדייקת בבעלי חיים למגדלי מעלי גירה קטנים
Creators: name: Godo, Assaf
Publisher: name: Zenodo
Year: 2024
Subjects: sheep
goats
technologies

description: מדריכים לכלים דיגיטליים ופתרונות בחקלאות מדייקת בבעלי חיים למגדלי מעלי גירה קטניםדוח זה הוא סדרה של מדריכים שמנחים כיצד להשתמש בכלים דיגיטליים ובחקלאות מדייקת בבעלי חיים המיועדים למעלי גירה קטנים. הכנו 30 קווים מנחים, בסדר הבא:1.    הדמיה תלת מימדית2.    אופטימיז- אפליקציית ניהול עבודה במשק3.    קורא תגים מזהים בכון חלב4.    הזנה אוטומטית5.    מד לחות אוטומטי למרעה6.    מינקת7.    מצלמה8.    גדרות מחוברות9.    מד מים מחובר10.    מסוע לטיפול בכבשים11.    תג אוזן RFID בתדר גבוה12.    הורות גנומית13.    רחפנים14.    משקל טנק חלב דינמי15.    משקל אוטומטי עם יכולת זיהוי אלקטרוני ומערכת ניתוב16.    תחנת מזג אוויר- מאוורר מצנן17.    פקפק- ג'י218.    מתכנן מנות הזנה19.    תוכנת ניהול עדר20.    אפליקציית הקלטת עדר21.    קולר ג'י.פי.אס.22.    מוט קריאת נתונים EID23.    מד חלב24.    מכשיר נירס נייד25.    מונה תאים סומטיים26.    טכנולוגיית ייבוש חציר לעזים27.    מכשיר בדיקת הריון28.    גדר וירטואלית29.    מערכת שקילה מהירה (WoW)30.    מעקב שקילה באמצעות שוקת חכמה
Additional file 1 of The Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C) for serious mental illness in community mental health part 1: study protocol for a hybrid type 2 effectiveness-implementation cluster-randomized trial
Creators: name: Sarfan, Laurel D.
name: Agnew, Emma R.
name: Diaz, Marlen
name: Dong, Lu
name: Fisher, Krista
name: Spencer, Julia M.
name: Howlett, Shayna A.
name: Hache, Rafael Esteva
name: Callaway, Catherine A.
name: Kilbourne, Amy M.
name: Buysse, Daniel J.
name: Harvey, Allison G.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. SPIRIT checklist.
Cardioprotective effects of semaglutide on isolated human ventricular myocardium
Creators: name: Krammer, Thomas
name: Baier, Maria J.
name: Hegner, Philipp
name: Zschiedrich, Tilman
name: Lukas, David
name: Wolf, Matthias
name: Le Phu, Christian
name: Lutz, Vanessa
name: Evert, Katja
name: Kozakov, Kostiantyn
name: Li, Jing
name: Holzamer, Andreas
name: Maier, Lars S.
name: Provaznik, Zdenek
name: Bers, Donald M.
name: Wagner, Stefan
name: Mustroph, Julian
Publisher: name: Universität Regensburg
Year: 2025
Subjects: subject: Calcium • Heart failure • Human cardiomyocytes • Semaglutide
subject: 610 Medizin

description: Aims
Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, has shown promising effects in reducing cardiovascular events in patients with obesity and heart failure (HF) with preserved ejection fraction (HFpEF) irrespective of concomitant diabetes. However, the exact mechanisms underlying its cardioprotective actions remain unclear. Our study investigates the direct effects of semaglutide on human cardiomyocytes, focusing on calcium (Ca) and sodium (Na) handling and its potential to improve myocardial contractility.

Methods and results
Human left ventricular cardiomyocytes were isolated from non-failing (NF) hearts, patients with aortic stenosis and a HFpEF-like phenotype (AS), and those with end-stage HF with reduced ejection fraction (HFrEF). Late Na current (INa), sarcoplasmic reticulum (SR) Ca leak, and contractility were assessed in isolated cardiomyocytes treated with semaglutide. CaMKII inhibitor autocamtide-2-related inhibitory peptide and GLP-1 receptor antagonist exendin 9–39 (Ex-9-39) were used to elucidate signalling pathways. Semaglutide reduced late INa in AS and HFrEF cardiomyocytes to levels comparable to NF. Additionally, semaglutide decreased diastolic SR Ca leak and improved systolic Ca transients and contractility in AS and HFrEF tissue. These effects were mediated through GLP-1 receptor agonism and were comparable to CaMKII inhibition. In multicellular preparations, semaglutide differentially improved myocardial contractility in AS and HFrEF in a dose-dependent manner.

Conclusion
Semaglutide directly modulates ion homeostasis in human cardiomyocytes, reducing proarrhythmic diastolic SR Ca leak and enhancing systolic function, which may explain its observed clinical benefits. These findings provide mechanistic insights into the cardioprotective effects of semaglutide and suggest its potential therapeutic use in H
sj-pdf-1-ejo-10.1177_11206721211044328 – Supplemental material for Cataract extraction and intraocular pressure-lowering agents delivery: A nationwide French study between 2005 and 2017
Creators: name: Chamard, Chloé
name: Huguet, Héléna
name: Bron, Alain M
name: Creuzot-Garcher, Catherine
name: Nogue, Erika
name: Villain, Max
name: Nagot, Nicolas
name: Carrière, Isabelle
name: Mura, Thibault
name: Daien, Vincent
Publisher: name: SAGE Journals
Year: 2021
Subjects: Medicine

description: Supplemental material, sj-pdf-1-ejo-10.1177_11206721211044328 for Cataract extraction and intraocular pressure-lowering agents delivery: A nationwide French study between 2005 and 2017 by Chloé Chamard, Héléna Huguet, Alain M Bron, Catherine Creuzot-Garcher, Erika Nogue, Max Villain, Nicolas Nagot, Isabelle Carrière, Thibault Mura and Vincent Daien in European Journal of Ophthalmology
Modeling And Measuring Cycles, Processes, And Trends
Creators: name: Grinin, Leonid
name: Korotayev, Andrey
Publisher: name: Zenodo
Year: 2014
Subjects: economic cycles

description: The present Yearbook (which is the fourth in the series) is subtitled Trends &

Cycles. Already ancient historians (see, e.g., the second Chapter of Book VI of

Polybius' Histories) described rather well the cyclical component of historical

dynamics, whereas new interesting analyses of such dynamics also appeared in

the Medieval and Early Modern periods (see, e.g., Ibn Khaldūn 1958 [1377], or

Machiavelli 1996 [1531] 1). This is not surprising as the cyclical dynamics was

dominant in the agrarian social systems. With modernization, the trend dynamics

became much more pronounced and these are trends to which the students

of modern societies pay more attention. Note that the term trend – as regards its

contents and application – is tightly connected with a formal mathematical

analysis. Trends may be described by various equations – linear, exponential,

power-law, etc. On the other hand, the cliodynamic research has demonstrated

that the cyclical historical dynamics can be also modeled mathematically in

a rather effective way (see, e.g., Usher 1989; Chu and Lee 1994; Turchin 2003,

2005a, 2005b; Turchin and Korotayev 2006; Turchin and Nefedov 2009; Nefedov

2004; Korotayev and Komarova 2004; Korotayev, Malkov, and Khaltourina

2006; Korotayev and Khaltourina 2006; Korotayev 2007; Grinin 2007),

whereas the trend and cycle components of historical dynamics turn out to be

of equal importance.
MPEC 2025-F104 : 2025 FO4
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2025
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2025 FO4

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
CHEMISTRY TUTORING MOTIVATIONS IN THE TIME OF THE PANDEMIC
Creators: name: Chaffin, Patrick M
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Other chemical sciences not elsewhere classified

description: Tutoring is present on every university campus and available for nearly every discipline. Chemistry is no exception. The goal of this research study is to understand the motivations of chemistry students that are seeking tutoring during the first academic year of the COVID-19 pandemic. To accomplish this task, Self-Determination Theory was used to understand the extent to which the chemistry course did not satisfy the students' needs and how the participants felt these needs could be better satisfied through tutoring. Methodologically, this research is presented as a case study. This study set out to answer the following questions: What aspects of the chemistry course and content motivate tutees to seek out tutoring?; What aspects of the online learning environment created challenges that led tutees to seek out tutoring?; and What are the tutees' hopes and expectations of what tutoring can provide for them? It was found that many aspects of the course created an environment that left students with unsatisfied needs for competence, relatedness, and autonomy including but not limited to the lack of a relationship with their professor or TA and the amount of content the course presented. Many of these issues were bound up in the forced online nature of the course which did not provide enough scaffolding or relatedness-support leaving students desiring help. These results imply that students need more support in their courses, especially when those courses are online only. Support can take the form of more scaffolding in the course to help with issues of competence or reaching out to students and fostering communication amongst the students, professor, and TAs to support relatedness.