cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Walkability
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2014
Subjects: Stadtplanung
Gesundheitsvorsorge
Wohnumfeld
Flächennutzungsplanung

description: In Kontrast zu einer vorwiegend individuumszentrierten Bewegungsförderung liegt diesem Buch die Überzeugung zugrunde, dass eine nachhaltige und bevölkerungsweite Bewegungsförderung nur über einen transdisziplinären und intersektoral abgestimmten Ansatz erreicht werden kann, der bewegungsfreundliche Lebensbedingungen und Wohnumgebungen schafft. Hierzu ist der Walkability-Ansatz ein mögliches Schlüsselkonzept. Walkability umfasst dabei nicht nur die Begehbarkeit, sondern die gesamte Bewegungsfreundlichkeit von Straßenzügen, Wohnvierteln, Stadtteilen und urbanen Räumen.
Dieser Grundlagenband ist die erste deutschsprachige Einführung in den Walkability-Ansatz. Experten aus Deutschland, Österreich und der Schweiz stellen dieses innovative, komplexe und vielversprechende Konzept zur Bewegungsförderung aus der Sicht unterschiedlicher Disziplinen und Anwendungsfelder vor. Neben theoretischen Grundlagen, methodischen Standards und empirischen Befunden werden auch konkrete Beispiele für einen Praxistransfer vorgestellt.
Quelle: buchhandel.de
Feedback Loops of the Mammalian Circadian Clock Constitute Repressilator
Creators: name: Pett, J. Patrick
name: Korencic, Anja
name: Wesener, Felix
name: Kramer, Achim
name: Herzel, Hanspeter
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Mammals evolved an endogenous timing system to coordinate their physiology and behaviour to the 24h period of the solar day. While it is well accepted that circadian rhythms are generated by intracellular transcriptional feedback loops, it is still debated which network motifs are necessary and sufficient for generating self-sustained oscillations. Here, we systematically explore a data-based circadian oscillator model with multiple negative and positive feedback loops and identify a series of three subsequent inhibitions known as “repressilator” as a core element of the mammalian circadian oscillator. The central role of the repressilator motif is consistent with time-resolved ChIP- seq experiments of circadian clock transcription factors and loss of rhythmicity in core clock gene knockouts.
Conceptualizing mechanisms of human movement cancellation within a Pause-then-Cancel model of motor inhibition
Creators: name: Diesburg, Darcy A
Publisher: name: University of Iowa
Year: 2022
Subjects: basal ganglia
inhibitory control
motor inhibition
stop-signal task
public abstract

description: In this thesis, a novel theoretical framework of human motor inhibition, a translation of the two-stage Pause-then-Cancel model, is proposed. This framework is poised to resolve outstanding debates regarding the nature of relationships between attentional orienting and motor inhibition processes, as well as relative timing differences in purported neurophysiological signatures of motor inhibition. This model predicts that human motor inhibition occurs in two phases: the rapid and transient Pause phase, which is underpinned by the hyperdirect basal ganglia pathway and is elicited by any salient task stimulus, and the Cancel phase, which is underpinned by the indirect basal ganglia pathway and accounts for the ultimate cancellation of drive to movement (if task-instructed). Experimental findings on the network mechanisms of human motor inhibition are situated within this model, including findings of the broad suppression of corticospinal excitability during attentional orienting (which led to a recognition of the Pause phase in humans), investigations of subcortico-cortical beta bursts as purported inhibitory signals in the subcortical aspects of the Pause and Cancel circuits, and the causal role of the subthalamic nucleus in inhibitory signaling cascades within those pathways.
The SAMI Galaxy Survey: Gas streaming and dynamical M/L in rotationally supported systems
Creators: name: Cecil, G.
name: Fogarty, L. M. R.
name: Richards, S.
name: Bland-Hawthorn, J.
name: Lange, R.
name: Moffett, A.
name: Catinella, Barbara
name: Cortese, Luca
name: Ho, I.-T.
name: Taylor, Edward
name: Bryant, J. J.
name: Allen, J. T.
name: Sweet, Sarah
name: Croom, S. M.
name: Driver, S. P.
name: Goodwin, M.
name: Kelvin, L.
name: Green, A. W.
name: Konstantopoulos, I. S.
name: Owers, M. S.
name: Lawrence, J. S.
name: Lorente, N. P. F.
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 510103
subject: Cosmology and extragalactic astronomy

description: Line-of-sight velocities of gas and stars can constrain dark matter (DM) within rotationally supported galaxies if they trace circular orbits extensively. Photometric asymmetries may signify non-circular motions, requiring spectra with dense spatial coverage. Our integral-field spectroscopy of 178 galaxies spanned the mass range of the Sydney-AAO Multi-object integral field spectrograph (SAMI) Galaxy Survey. We derived circular speed curves (CSCs) of gas and stars from non-parametric fits out to r ∼ 2re. For 12/14 with measured H I profiles, ionized gas and H I maximum velocities agreed. We fitted mass-follows-light models to 163 galaxies by approximating the radial light profile as nested, very flattened mass homeoids viewed as a Sérsic form. Fitting broad-band spectral energy distributions to Sloan Digital Sky Survey images gave median stellar mass/light 1.7 assuming a Kroupa initial mass function (IMF) versus 2.6 dynamically. Two-thirds of the dynamical mass/light measures were consistent with star+remnant IMFs. One-fifth required upscaled starlight to fit, hence comparable mass of unobserved baryons and/or DM distributed like starlight across the SAMI aperture that came to dominate motions as the starlight CSCs declined rapidly. The rest had mass distributed differently from light. Subtracting fits of Sérsic radial profiles to 13 VIKING Z-band images revealed residual weak bars. Near the bar major axis, we assessed m = 2 streaming velocities, and found deviations usually <30 km s−1 from the CSC; three showed no deviation. Thus, asymmetries rarely influenced the CSC despite colocated shock-indicating, emission-line flux ratios in more than 2/3 of our sample.
Modeling of radial water/oil displacement in water-wet porous media.
Creators: name: Agharazi-Dormani, Nader.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1991
Subjects: subject: Engineering, Chemical.

description: The effects of five operating variables and four dimensionless groups on oil recovery and finger formation during the immiscible radial displacement of oil by water in a consolidated water-wet porous medium were investigated using statistical model building techniques. Two different approaches were used. In the first approach, experiments were carried out according to a central composite design with partial replication over the following operating region: (UNFORMATTED TABLE OR EQUATION FOLLOWS)$$\vbox{\halign{#\hfil&&\quad#\hfil\cr &Flow rate of injection fluid&0.65 $\le$ Q $\le$ 510.00 (mL/h)\cr &Radius of breakthrough&2.5 $\le$ R $\le$ 7.0 (cm)\cr &Viscosity difference&15 $\le\mu\sb{\rm o}$-$\mu\sb{\rm w} \le 152$ (mPa.s)\cr &Permeability&13.33 $\le$ K $\le$ 77.41 ($\mu$m$\sp2$)\cr&Interfacial tension (IFT)&0.3 $\le \gamma \le$ 30.0 (mN/m)\cr}}$$(TABLE/EQUATION ENDS) A second-order polynomial of the general form $$\rm Y = \beta\sb{o} + \sum\sbsp{i=1}{5} \beta\sb{i}X\sb{i} + \sum\sbsp{i=1}{5} \sum\sbsp{j=1}{5} \beta\sb{ij}X\sb{i}X\sb{j}$$was fitted to the data. It was found that for water-wet systems, the recovery decreased as the viscosity difference increased and this effect became more significant as the flow rate increased. Conversely, as the breakthrough radius or permeability of the cell increased, the recovery increased. The effect of IFT was negative and depended on the level of viscosity difference and permeability. In addition, an increase in flow rate, breakthrough radius or the viscosity difference resulted in an increase in the number of fingers, while high permeability reduced the number of fingers. The operating variables were grouped together in dimensionless terms such as the capillary number and the viscosity ratio, and the parameters ($\beta\sbsp{\rm i}{\prime}$s) were estimated for these terms. The recovery was found to be enhanced with an increase in the ratio of breakthrough radius to the cell thickness (R/h). It was reduced as the viscosity ratio increased and this attenuating effect became more significant as the flow rate increased. The effect of ratio of the cell thickness to the square root of the permeability (h/$\sqrt{K})$ and capillary number depended on the value of other variables. The number of fingers increased as any of the above ratios was increased with the exception of (h/$\sqrt{K})$ where the effect was more complex. (Abstract shortened by UMI.)
Fund-raising by non-profit agencies in the health area.
Creators: name: O'Brecht, Michael.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Business Administration, Marketing.

description: Non-profit health agencies are examined from three perspectives: their contribution to medical research by region and subject area; changes in their revenue sources and fund-raising techniques between 1982 and 1987; and, correlates of fund-raising effectiveness. Data are obtained from a survey of 1,103 health charities and foundations, interviews with the executive directors of six hospital foundations across Canada and statistics in the public domain. Results indicate that in comparison with the distribution of Federal government research grants, health agency research funding is more highly concentrated in one province, Ontario, and two subject areas, cardiovascular disease and cancer. Agencies appear to be obtaining larger proportions of their total funding from donations or business activities and smaller proportions from government grants or transfers. Large-established agencies are shifting fund-raising resources from canvassing to direct mail. Two variables, public awareness of the agency and the proportion of agency funds derived from donations, appear to be important correlates of agency effectiveness as measured by donations per fund-raising dollar. Small, positive correlations are noted between two indicators of a marketing approach and fund-raising outcome. Implications for future research are discussed.
Biodegradability and transformation of human pharmaceutical active ingredients in environmentally relevant test systems
Creators: name: Berkner, Silvia
name: Thierbach, Claudia
Publisher: name: My University
Year: 2013
Subjects: Biologischer Abbau
Belebtschlamm

description: Human pharmaceutical active ingredients that are orally or parenterally administered may be metabolised in the body and after excretion may be further transformed in the receiving environmental compartments. The optimal outcome from an environmental point of view-complete mineralisation-is rarely observed. Small molecule pharmaceuticals are commonly not readily biodegradable according to Organisation for Economic Cooperation and Development (OECD) 301 tests. However, primary transformation is often observed. To gain information on the transformation of active ingredients in the environment, long-term studies like transformation in aquatic water/sediment systems according to OECD guideline 308 are required for the environmental risk assessment for human active pharmaceutical ingredients. Studies received until mid 2010 as part of the dossiers for marketing authorisation applications were evaluated concerning transformation products. The evaluation revealed that in 70 % of the studies, at least one transformation product (TP) is formed above 10 % of the originally applied dose, but in only 26 % of the studies are all TP identified. The evaluation also revealed that some TP of pharmaceutical active ingredients show a considerably longer DT50 compared to the parent compound. An example is the TP (val)sartan acid that is formed from an antihypertensive compound.
Quelle: http://link.springer.com
Improving the pair separation of WW/ZZ at the ILC by consideration of photon radiation in kinematic fits
Creators: name: Beckmann, Moritz
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2010
Subjects: thesis
electron positron: annihilation
intermediate boson: pair production
intermediate boson: hadronic decay
particle identification: (Z0 W)
photon: radiation
beam: radiation
radiation: initial-state interaction
kinematics
photon: momentum spectrum
mass resolution
numerical calculations: Monte Carlo
ILD
ILC Coll

description: Leibniz Universität Hannover, Diplomarbeit, 2010; 76 pp., (2010). doi:10.3204/DESY-THESIS-2010-014
description: Published by Deutsches Elektronen-Synchrotron, DESY, Hamburg
Blood Mitochondrial DNA Content in HIV-Exposed Uninfected Children with Autism Spectrum Disorder
Creators: name: Budd, Matthew A.
name: Calli, Kristina
name: Samson, Lindy
name: Bowes, Jennifer
name: Hsieh, Anthony Y. Y.
name: Forbes, John C.
name: Bitnun, Ari
name: Singer, Joel
name: Kakkar, Fatima
name: Alimenti, Ariane
name: Maan, Evelyn J.
name: Lewis, M. E. Suzanne
name: Gentile, Carole
name: Côté, Hélène C. F.
name: Brophy, Jason C.
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Long-term outcomes of perinatal exposure to maternal antiretroviral therapy in HIV-exposed uninfected (HEU) children are unknown. However, both HIV antiretroviral therapy and autism spectrum disorder (ASD) have been associated with mitochondrial alterations. Leukocyte mitochondrial DNA (mtDNA) content can serve as a marker for mitochondrial dysfunction. In this cross-sectional, nested case-control study, HEU children with ASD were matched approximately 1:3 on age, sex, and ethnicity to HEU children without ASD, HIV-unexposed uninfected (HUU) controls, and HUU children with ASD. Leukocyte mtDNA content was measured using quantitative PCR. Among 299 HEU in this study, 14 (4.7%) were diagnosed with ASD, which is higher than the general population prevalence estimates. HEU children without ASD and HUU children with ASD had higher mtDNA content than HUU controls. HEU children with ASD had significantly higher mtDNA content than all other study groups. Our results suggest a clear association between elevated leukocyte mtDNA content and both HEU and ASD status. This may implicate mitochondrial dysfunction as a contributor to the high ASD prevalence observed in our cohort.
Computational modeling of proteins implicated in hearing loss
Creators: name: Tollefson, Mallory RaNae
Publisher: name: University of Iowa
Year: 2023
Subjects: subject: Biophysical Simulation
subject: Protein Modeling
subject: Variants of Uncertain Significance
subject: public abstract
subject: Deafness
subject: Genetics
subject: FOS: Biological sciences
subject: Machine Learning

description: Hearing loss is associated with over 128,500 missense variants spanning 219 genes, and approximately 6,300 of those missense variants have been classified as disease causing. However, seventy percent of these variants are classified as “variants of uncertain significance” (VUS) due to the inability to ascertain phenotypic effect from genotype. Experimental assessment (i.e., protein assays, model organisms, etc.) of over 90,000 missense variants is intractable, leaving variant characterization as the primary bottleneck to providing a genetic diagnosis from an identified missense variant.
description: Computational methods for variant classification can be used to highlight variants that merit costly experimental evaluation. However, computational tools for identifying deleterious variants often require the existence of an accurate three-dimensional protein model, a priori. To address the need for three-dimensional protein models, we developed Likelihood Recurrent Geometric Network (Likelihood-RGN), a machine learning algorithm for ab initio prediction of protein models. Likelihood-RGN builds on the RGN algorithm by enhancing the least squares loss function with a maximum likelihood loss function that includes experimental uncertainty data in the form of atomic displacement parameters. We then used machine learning (namely, the emergent AlphaFold2 algorithm) to develop protein models for the entire deafness proteome.
description: Although machine learning-based protein models provide coordinates where experimental data are not available, such models often contain discrepancies from biophysical expectations such as steric clashes and high-energy side-chain conformations. To make these protein predictions consistent with biophysical expectations, we accelerated the many-body side-chain optimization algorithm with novel approximations and used the algorithm to repack all machine learning models for the deafness proteome. Finally, we used our models to predict folding free energy differences (∆∆G), compute solvent accessible surface areas, identify protein model confidence, and collect CADD scores and minor allele frequencies for all 128,500 missense variants associated with deafness. We exploited these features to identify ∆∆G and CADD cutoffs that are consistent with deleteriousness, and we identify 3,456 destabilizing VUSs that are pathogenic at a probability of 99.0%. The work presented in this dissertation establishes a protein modeling protocol that identifies VUSs that are most likely disease-causing and uses this protocol to prioritize deafness-implicated VUSs.
Z-FIRE: ISM PROPERTIES of the z = 2.095 COSMOS CLUSTER
Creators: name: Kewley, Lisa J.
name: Yuan, Tiantian
name: Nanayakkara, Themiya
name: Kacprzak, Glenn
name: Tran, Kim-Vy H.
name: Glazebrook, Karl
name: Spitler, Lee
name: Cowley, Michael
name: Dopita, Michael
name: Straatman, Caroline
name: Labbe, Ivo
name: Tomczak, Adam
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 510103
subject: Cosmology and extragalactic astronomy

description: We investigate the ISM properties of 13 star-forming galaxies within the z~2 COSMOS cluster. We show that the cluster members have [N ii]/Hα and [O iii]/Hβ emission-line ratios similar to z~2 field galaxies, yet systematically different emission-line ratios (by ~0.17 dex) from the majority of local star-forming galaxies. We find no statistically significant difference in the [N ii]/Hα and [O iii]/Hβ line ratios or ISM pressures among the z~2 cluster galaxies and field galaxies at the same redshift. We show that our cluster galaxies have significantly larger ionization parameters (by up to an order of magnitude) than local star-forming galaxies. We hypothesize that these high ionization parameters may be associated with large specific star formation rates (SFRs; i.e., a large SFR per unit stellar mass). If this hypothesis is correct, then this relationship would have important implications for the geometry and/or the mass of stars contained within individual star clusters as a function of redshift.
title: The rhetoric of recipes in motion
title: neoliberal multiculturalism in early digital discourse about food
titleType: Subtitle
Creators: name: Snelling, Tyler J.
Publisher: name: University of Iowa
Year: 2024
Subjects: Community
Digital culture
Discourse
Food
Neoliberal multiculturalism
Platform
public abstract
History

description: People create, share, and find recipes that locate them within complex social systems as expressions of who we are and what we want. The instructional qualities of recipes pairs well with their cultural functions as discourses that mold ideas about food. This project analyzes tastes created through the movement of recipes on digital platforms in the 1980s and 1990s. Beginning with newsgroups on the User’s Network and throughout the Internet’s establishment, thousands of people exchanged recipes with instructions for foods from cultures marked as outside the United States. Rather than cultural respect or openness, I argue that digital recipe exchange encouraged neoliberal multiculturalism by simplifying and capitalizing on people’s cultural connections to food. This project develops neoliberal multiculturalism as a theory for studying tastes that simultaneously celebrate a worldly appetite by centering many different cultures while flattening the very foods supposedly reflecting this openness. Three case studies enable me to unpack neoliberal multiculturalism as a structure informing taste. Discourses in the USENET Cookbook appealed to pseudo-authenticity, thereby celebrating ethnic connections while erasing cultural significance attached to food. Chefs on Food Network pushed users to aspire towards cosmopolitanism by exploring and incorporating ethnic cuisines with the aim to develop a shallow but sophisticated appetite. People’s engagement with Allrecipes commodified ethnic cuisines by concretizing and then monetizing a procedure for exchanging recipes. Digital recipe exchange provided a set of mundane activities where people learned and expressed their interests toward food in a manner that helped establish neoliberal multiculturalism as a dominant ideological structure. This dissertation expands food studies, rhetorical studies, and digital humanities by arguing that digital recipe exchange provided practices where people’s instructions also established raced, classed, and nationalized ideas about eating and cooking.
title: Sexual interaction in action
title: consent and agency in the sexual communications of early adolescents and adults
titleType: Subtitle
Creators: name: Rittenhour, Kathryn
Publisher: name: University of Iowa
Year: 2022
Subjects: Consent
Sex Scripts
Sexual Agency
Unwanted Sex
public abstract
Sexual Behavior

description: A feminist debate is still raging in sexualities literature and popular culture: is sex dangerous or empowering for women and other marginalized people? This dissertation applies an agency-within-constraint framework to examine actors’ capacity to practice sexual agency within oppressive institutions or interactions. To do this, I use electronic and in-person sexual communications to examine how adolescents and adults, belonging to different sex communities, act on their sexual needs and desires while navigating systems of constraint. This dissertation utilizes radical and liberal feminist frameworks to critique violence and male dominance while treating women and girls as sexual agents. First, I find that the ability to successfully negotiate sex is intimately tied to the sexual scripts and communities that a person is embedded in. Importantly, sexual agency can grow through exposure to new scripts. Next, I find that sexual coercion and consent can exist simultaneously within sexual interactions. I argue that consenting to sex, even unwanted sex, is an expression of sexual agency. Finally, I find that cybercommunications can put young people at risk for sexual harassment and violence but also facilitate sexual learning and agency. Young people develop their sexual identities, in part, through low-risk, consensual sharing of sexual content. These findings suggest that victimization and agency are not mutually exclusive and have important implications for theory and advocacy. Monolithic definitions of consent and violence leave room for dire misinterpretations of “nonnormative” sexual practices and erase the nuances common in everyday sexual interactions.
Leitfaden zur umweltfreundlichen öffentlichen Beschaffung: Grafische Papiere und Kartons aus 100 % Altpapier (Recyclingpapier und -karton)
Creators: name: (:Unkn) Unknown
Publisher: name: Umweltbundesamt
Year: 2022
Subjects: subject: Recyclingpapier
subject: Recyclingkarton
subject: Grafische Papiere
subject: Kopierpapier
subject: Wirtschaft | Konsum

description: Die Beschaffung von Recyclingpapier und -karton trägt zur Schonung von Ressourcen, insbesondere des Ökosystems Wald und damit zum Arten- und Klimaschutz bei. Mit den Kriterien des Leitfaden soll zudem die Zugabe von kritischen Fabrikations- und Papierveredlungsstoffen begrenzt werden, um die Belastung des Abwassers zu minimieren und die Belastung des Papiers mit Schadstoffen zu reduzieren. Zum Schutz der Gesundheit muss grafisches Recyclingpapier, das zum Bedrucken mittels elektrofotografischer Verfahren bestimmt ist (z. B. Kopierpapier), hinsichtlich seines Potenzials zur Emission von flüchtigen organischen Stoffen (TVOC und TSVOC und DIPN) geprüft werden. Dieser Leitfaden basiert auf den Kriterien des Umweltzeichens Blauer Engel für Recyclingpapier und -karton (DE-UZ 14a, Ausgabe Januar 2020). Quelle: www.umweltbundesamt.de
description: Die Beschaffung von Recyclingpapier und -karton trägt zur Schonung von Ressourcen, insbesondere des Ökosystems Wald und damit zum Arten- und ⁠Klimaschutz⁠ bei. Mit den Kriterien des Leitfaden soll zudem die Zugabe von kritischen Fabrikations- und Papierveredlungsstoffen begrenzt werden, um die Belastung des Abwassers zu minimieren und die Belastung des Papiers mit Schadstoffen zu reduzieren. Zum Schutz der Gesundheit muss grafisches Recyclingpapier, das zum Bedrucken mittels elektrofotografischer Verfahren bestimmt ist (z. B. Kopierpapier), hinsichtlich seines Potenzials zur ⁠Emission⁠ von flüchtigen organischen Stoffen (TVOC und TSVOC und DIPN) geprüft werden.Dieser Leitfaden basiert auf den Kriterien des Umweltzeichens Blauer Engel für Recyclingpapier und -karton (DE-UZ 14a, Ausgabe Januar 2020).
Stress management outcome: Prediction of differential outcome by personality characteristics.
Creators: name: Weld, Suzanne Edna.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Psychology, Clinical.

description: This study examined differential outcome between two stress management approaches according to subject characteristics. It was hypothesized that individuals with certain characteristics might benefit more from one form of stress management training (Rational Emotive Therapy) than another (Gendlin Focusing). The implication, were this hypothesis to be supported, would be that individuals could be streamed into one form of training versus another, according to certain personality variables, and the result would be greater effectiveness and efficiency in the delivery of services. Subjects were classed as having one of two sets of characteristics. One class of subjects (N = 34) displayed stress cognitively on the Cognitive-Somatic Anxiety Questionnaire (CSAQ) and were of the Sensing type on the Myers-Briggs Type Indicator (MBTI) while the other class of subjects (N = 31) displayed their stress somatically on the CSAQ and were of the Intuitive type on the MBTI. Based on personality theory, cognitively anxious Sensing types were predicted to have greater decreases in stress as a result of receiving a Rational Emotive Therapy approach to stress management while somatically anxious Intuitive types were predicted to have greater decreases in stress as a result of receiving a Gendlin Focusing approach to stress management. Additional measures of client characteristics were taken in order to explore the predictive potential of variables which the literature indicates might be useful in predicting differential outcome. These included Locus of Control, Verbal Reasoning, Abstract Reasoning, Experiencing Ability, Rational Beliefs. A measure of stress (Symptom Check List-90-R) was taken at three points in time: pre, post-training (or post-waiting as in the case of the waiting-list controls), and at one-month follow-up. A waiting-list control group (N = 30) was utilized to demonstrate a treatment versus no treatment comparison. Treatment group subjects received 12-15 hours of stress management training in either (Rational Emotive Therapy) RET or Focusing spread over 5 weeks. Half of each class of subjects received RET while the other half of each class of subjects received Focusing. Key results include: Both classes of treatment subjects displayed significantly greater reductions (p .05) in stress levels after training as compared to waiting-list control subjects who had not received training over the same period of time. The main hypothesis was not supported. There were no statistically significant treatment by classification interactions. However, there were relationships between client satisfaction, use of the techniques, and decrease in reported levels of stress. Further analyses showed that none of the variables were significant predictors of outcome. This Study introduced Focusing as a viable stress management technique.
3696126.pdf
Creators: name: Shekhar, Prashant
name: Pendharker, Sarang
name: Sahasrabuddhe, Harshad
name: Vick, Douglas
name: Malac, Marek
name: Rahman, Rajib
name: Jacob, Zubin
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: supp info
The human fetal adrenal produces cortisol but no detectable aldosterone throughout the second trimester
Creators: name: Johnston, Zoe C
name: Bellingham, Michelle
name: Filis, Panagiotis
name: Soffientini, Ugo
name: Hough, Denise
name: Bhattacharya, Siladitya
name: Simard, Marc
name: Hammond, Geoffrey L
name: King, Peter
name: O’Shaughnessy, Peter J
name: Fowler, Paul A
Publisher: name: BioMed Central
Year: 2018

description: Background: Human fetal adrenal glands are highly active and, with the placenta, regulate circulating progesterone, estrogen and corticosteroids in the fetus. At birth the adrenals are essential for neonate salt retention through secretion of aldosterone, while adequate glucocorticoids are required to prevent adrenal insufficiency. The objective of this study was to carry out the first comprehensive analysis of adrenal steroid levels and steroidogenic enzyme expression in normal second trimester human fetuses. Methods: This was an observational study of steroids, messenger RNA transcripts and proteins in adrenals from up to 109 second trimester fetuses (11 weeks to 21 weeks) at the Universities of Aberdeen and Glasgow. The study design was balanced to show effects of maternal smoking. Results: Concentrations of 19 intra-adrenal steroids were quantified using liquid chromatography and mass spectrometry. Pregnenolone was the most abundant steroid while levels of 17α-hydroxyprogesterone, dehydroepiandrosterone sulphate (DHEAS) and progesterone were also high. Cortisol was present in all adrenals, but aldosterone was undetected and Δ4 androgens were low/undetected. CYP17A1, CYP21A2 and CYP11A1 were all highly expressed and the proteins localized to the adrenal fetal zone. There was low-level expression of HSD3B and CYP11B2, with HSD3B located mainly in the definitive zone. Maternal smoking altered fetal plasma adrenocorticotropic hormone (ACTH) (P = 0.052) and intra-adrenal progesterone, 17α-hydroxyprogesterone and 16α-hydroxyprogesterone, but not plasma or intra-adrenal cortisol, or intra-adrenal DHEAS. Fetal adrenal GATA6 and NR5A1 were increased by maternal smoking. Conclusions: The human fetal adrenal gland produces cortisol but very low levels of Δ4 androgens and no detectable aldosterone throughout the second trimester. The presence of cortisol in fetal adrenals suggests that adrenal regulation of circulating fetal ACTH remains a factor in development of congenital adrenal hyperplasia during the second trimester, while a relative lack of aldosterone explains the salt-wasting disorders frequently seen in extreme pre-term neonates. Finally, maternal smoking may alter fetal adrenal sensitivity to ACTH, which could have knock-on effects on post-natal health.
An examination of factors involved in the developing self-concept of adolescents in a congregated program for gifted high school students.
Creators: name: Frame, Barbara Kuhnke.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1991
Subjects: subject: Education, Sociology of.

description: This qualitative study focused on some of the factors and dynamics which may be affecting the self-concept and ensuing self-esteem of adolescents in a congregated high school program for academically gifted students. Interview data revealed that although students reflected positively on the opportunity to be with other students who had similar abilities and interests, and although they formed their closest friendships with other gifted students, they perceived social acceptance to be more difficult for them than for age-peers not identified as gifted. This was particularly evident in female responses. The gifted students appeared to have a strong sense of instrumentality and accepted decision-making as primarily their own responsibility, but they felt powerless to make pertinent decisions within the school and were therefore frustrated. Many of them also had diminished feelings of usefulness or helpfulness once enrolled in the gifted program. With regard to the increased level of competition, the findings were divided by gender. Most of the males enjoyed or accepted the competition but most of the females expressed active dislike for it and/or opted out of the competitiveness within the gifted program. They emphasized the crucial role that teachers and other school professionals play in affecting their present and future achievements, attitudes and decision-making. (Abstract shortened by UMI.)
3696126.pdf
Creators: name: Shekhar, Prashant
name: Pendharker, Sarang
name: Sahasrabuddhe, Harshad
name: Vick, Douglas
name: Malac, Marek
name: Rahman, Rajib
name: Jacob, Zubin
Publisher: name: Optica Publishing Group
Year: 2018
Subjects: Uncategorized

description: supp info
title: Kid-dult
title: Play-create
titleType: Subtitle
Creators: name: Ward, Lilah
Publisher: name: University of Iowa
Year: 2023
Subjects: art
ceramics
journal
public abstract
Play
Printmaking
Textiles

description: My thesis consists of listed references, influences, and interests, nostalgic and current that relate to or have impacted or influenced my practice, way of working, or seeing. The majority of the text is a journal I kept for the last two years and four semesters of my time as a graduate student that reflects on my grad experience at the University of Iowa, and things that have influenced my work, and practice.
Experimental application of QCD antennas
Creators: name: Bobrovskyi, Sergei
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2009
Subjects: thesis
p p: interaction
new physics
jet: multiple production
quantum chromodynamics
supersymmetry
supergravity: minimal
phase space
pole
cross section
parton: scattering
data analysis method
CMS
CERN LHC Coll
numerical calculations: Monte Carlo

description: Universität Hamburg, Diplomarbeit, 2009; 125 pp., (2009). doi:10.3204/DESY-THESIS-2010-003
description: A serious problem in searches for new physics at the LHC is the rejection of QCD induced multijet events. In this thesis the formalism of QCD antenna variables based on the SPHEL approximation of QCD matrix elements is applied for the rst time on experimentally reconstructed jets in order to discriminate QCD from supersymmetric processes. The new observables provide additional information with respect to traditional event shape variables. Albeit correlated with experimentally measured missing transverse energy, the variables can be used to improve the signal to background ratio.
description: Published by Deutsches Elektronen-Synchrotron, DESY, Hamburg
Radio galaxies in ZFOURGE/NMBS: no difference in the properties of massive galaxies with and without radio-AGN out to z = 2.25
Creators: name: Rees, G. A.
name: Spitler, L. R.
name: Norris, R. P.
name: Cowley, M. J.
name: Papovich, C.
name: Glazebrook, Karl
name: Quadri, R. F.
name: Straatman, C. M. S.
name: Allen, Rebecca
name: Kacprzak, Glenn
name: Labbe, Ivo
name: Nanayakkara, Themiya
name: Tomczak, A. R.
name: Tran, K.-V.
Publisher: name: Swinburne
Year: 2024
Subjects: classificationCode: 510103
subject: Cosmology and extragalactic astronomy

description: In order to reproduce the high-mass end of the galaxy mass distribution, some process must be responsible for the suppression of star formation in the most massive of galaxies. Commonly active galactic nuclei (AGN) are invoked to fulfil this role, but the exact means by which they do so is still the topic of much debate, with studies finding evidence for both the suppression and enhancement of star formation in AGN hosts. Using the ZFOURGE (FourStar Galaxy Evolution) and NMBS(Newfirm Medium Band Survey) galaxy surveys, we investigate the host galaxy properties of a mass-limited (M >= 10(10.5)M(circle dot)), high-luminosity (L-1.4 > 10(24) W Hz(-1)) sample of radio-loud AGN to a redshift of z = 2.25. In contrast to low-redshift studies, which associate radio-AGN activity with quiescent hosts, we find that the majority of z > 1.5 radio-AGN are hosted by star-forming galaxies. Indeed, the stellar populations of radio-AGN are found to evolve with redshift in a manner that is consistent with the non-AGN mass-similar galaxy population. Interestingly, we find that the radio-AGN fraction is constant across a redshift range of 0.25 = z < 2.25, perhaps indicating that the radio-AGN duty cycle has little dependence on redshift or galaxy type. We do however see a strong relation between the radio-AGN fraction and stellar mass, with radio-AGN becoming rare below similar to 10(10.5)M(circle dot) or a halo mass of 10(12)M(circle dot). This halo-mass threshold is in good agreement with simulations that initiate radio-AGN feedback at this mass limit. Despite this, we find that radio-AGN host star formation rates are consistent with the non-AGN mass-similar galaxy sample, suggesting that while radio-AGN are in the right place to suppress star formation in massive galaxies they are not necessarily responsible for doing so.
A comparative investigation into the mechanisms that support multidimensional categorization
Creators: name: O'Donoghue, Ellen Marian
Publisher: name: University of Iowa
Year: 2022
Subjects: associative
categorization
comparative
dual-systems
learning
pigeon
public abstract

description: Numerous studies have reported dissociations between rule-based (RB) tasks, which are assumed to engage declarative decision rules, and information-integration (II) tasks, which are assumed to engage associative category learning mechanisms. However, it remains unclear whether successful RB- and II-learners reliably deploy distinct strategies. The experiments reported here explored novel means of assessing which mechanisms participants use to solve RB and II tasks. We conducted a series of cross-species comparisons between humans, who are believed to possess both declarative and associative mechanisms, and pigeons, who are believed to possess only associative mechanisms. In accordance with a prominent dual-systems framework – the COVIS categorization model (Ashby, Alfonso-Reese, Turken, & Waldron, 1998) – we found that pigeons appeared to solve both RB and II tasks using associative mechanisms, whereas humans appeared to solve RB tasks through unidimensional decision rules and likewise explored unidimensional rules in the early stages of II tasks. However, contrary to the predictions of COVIS, II tasks did not reliably encourage human participants to abandon declarative mechanisms; instead, most II-learners appeared to develop alternative declarative strategies. We also found that pigeons, despite showing no evidence of declarative processing, robustly succeeded at tasks that challenged even human learners, suggesting that associative learning mechanisms merit far greater attention than they often receive in the broader category learning literature.
Inclusion during school absence: Using ambient technology to create a classroom presence for hospitalised children
Creators: name: Vetere, Frank
name: Green, Julie
name: Nisselle, Amy
name: Thu Dang, Xuan
name: Zazryn, Tsharni
name: Peng Deng, Paul
Publisher: name: Swinburne
Year: 2024

description: In this paper, we investigate the use of ambient technology to create a classroom presence for hospitalised children. We present results from four case studies, each of which included data from hospitalised children, their parents, classmates and teachers (at both school and hospital). Primary school-aged children from both metropolitan and rural areas were included. Data collected at both the hospital and the classroom were analysed to investigate children's experience of the ambient technology and their desire to be aware of the presence of their peers, from both ends of the hospital-school setting. The results indicate that ambient technology is positive at fostering a mutual sense of presence, from the perspective of the hospitalised children, their family, teachers and classmates. © 2012 Swinburne University of Technology.
Molecular analyses of the human retina and choroid at the single cell level
Creators: name: Voigt, Andrew Paul
Publisher: name: University of Iowa
Year: 2023
Subjects: choroid
retina
single-cell
public abstract

description: Age-related macular degeneration (AMD) is a common cause of irreversible blindness globally. The disease results in loss of light-sensing photoreceptor cells in the center of the retina (termed the macula), disrupting detailed, central vision. While the pathogenesis of AMD is multifactorial, the disease disturbs the homeostatic relationships between three important tissues in vision physiology: the neural retina, the retinal pigment epithelium, and the choroid.
description: We set out to identify molecular features of these tissues in both health and human retinal disease by performing single-cell RNA sequencing (scRNA-seq). We discovered three overarching findings that provide mechanistic insight into the pathogenesis of AMD. First, we identified that neural retinal cells have different gene expression profiles in different regions, and the central-most foveal cone photoreceptor cells and Müller glial cells are unique. These different retinal regions also manifest distinct gene expression changes in the setting of human retinal degeneration. Second, we characterized gene expression patterns in the human retinal pigment epithelium and underlying choroid, and we identified discrete populations of choroidal arteries, veins, and choriocapillaris endothelial cells (which are the first cells to degenerate in AMD). We discovered that with advancing age, choriocapillaris endothelial cells adopt a pro-inflammatory phenotype with increased expression of leukocyte adhesion molecules. Third, we developed Spectacle, a free web-based platform for interactive scRNA-seq analysis of human ocular tissues. Spectacle allows for rapid exploration of gene expression across all the enclosed datasets and increases accessibility of this data for the vision research community.
title: A novel preventive therapy for paclitaxel-induced cognitive deficits
title: preclinical evidence from C57BL/6 mice
titleType: Subtitle
Creators: name: Huehnchen, P.
name: Boehmerle, W.
name: Springer, A.
name: Freyer, D.
name: Endres, M.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Chemotherapy-induced central nervous system (CNS) neurotoxicity presents an unmet medical need. Patients often report a cognitive decline in temporal correlation to chemotherapy, particularly for hippocampus-dependent verbal and visuo-spatial abilities. We treated adult C57Bl/6 mice with 12 × 20 mg kg−1 paclitaxel (PTX), mimicking clinical conditions of dose-dense chemotherapy, followed by a pulse of bromodesoxyuridine (BrdU) to label dividing cells. In this model, mice developed visuo-spatial memory impairments, and we measured peak PTX concentrations in the hippocampus of 230 nm l−1, which was sevenfold higher compared with the neocortex. Histologic analysis revealed a reduced hippocampal cell proliferation. In vitro, we observed severe toxicity in slowly proliferating neural stem cells (NSC) as well as human neuronal progenitor cells after 2 h exposure to low nanomolar concentrations of PTX. In comparison, mature post-mitotic hippocampal neurons and cell lines of malignant cells were less vulnerable. In PTX-treated NSC, we observed an increase of intracellular calcium levels, as well as an increased activity of calpain- and caspase 3/7, suggesting a calcium-dependent mechanism. This cell death pathway could be specifically inhibited with lithium, but not glycogen synthase kinase 3 inhibitors, which protected NSC in vitro. In vivo, preemptive treatment of mice with lithium prevented PTX-induced memory deficits and abnormal adult hippocampal neurogenesis. In summary, we identified a molecular pathomechanism, which invokes PTX-induced cytotoxicity in NSC independent of cell cycle status. This pathway could be pharmacologically inhibited with lithium without impairing paclitaxel’s tubulin-dependent cytostatic mode of action, enabling a potential translational clinical approach.
Gravitino and scalar $\tau$-lepton decays in supersymmetric models with broken R-parity
Creators: name: Hajer, Jan
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2010
Subjects: thesis
supersymmetry
supergravity
Higgs mechanism
R parity: violation
symmetry breaking
minimal supersymmetric standard model
sparticle: mass
neutrino: mass generation
gravitino: decay
stau: decay
grand unified theory
SU(5)
U(1)
flavor
sparticle: mixing
renormalization group
bibliography

description: Universität Hamburg, Diplomarbeit, 2010; 98 pp., (2010). doi:10.3204/DESY-THESIS-2010-021
description: Published by Deutsches Elektronen-Synchrotron, DESY, Hamburg
Initial findings on COVID-19-induced changes to material consumption and mobility behavior
Creators: name: Bodenheimer, Miriam
name: Brauer, Clemens
name: Schuler, Johannes
Publisher: name: Umweltbundesamt
Year: 2023
Subjects: subject: Konsumverhalten
subject: Mobilitätsverhalten
subject: consumption habit
subject: mobility behaviour
subject: COVID-19
subject: Economy | Consumption
subject: Transport

description: In diesem Arbeitspapier werden die Ergebnisse einer länderübergreifenden Erhebung zu Covid 19-bedingten Veränderungen der Konsumgewohnheiten mit Schwerpunkt auf nicht lebensnotwendige Konsumgüter und dem Mobilitätsverhalten vorgestellt. Die Erhebung (n=4000) wurde Anfang 2021 in Deutschland, Italien, Japan und den Vereinigten Staaten durchgeführt. Die Ergebnisse zeigen erste Tendenzen zu einem nachhaltigeren Verhalten im Bereich nicht lebensnotwendiger Konsumgüter, insbesondere eine Reduzierung der Käufe und die Erkenntnis, dass die nicht gekauften Gegenstände nicht vermisst wurden. Während es ebenfalls signifikante pandemiebedingte Veränderungen in der Mobilität gab, sowohl in Bezug auf die Häufigkeit und den Zweck von Fahrten als auch auf die Verkehrsmittel, lassen die Zukunftsabsichten der Befragten keine signifikanten Gewinne an Nachhaltigkeit in diesem Bereich erwarten. Quelle: Forschungsbericht
description: This paper presents the results of a multicountry survey on Covid-19-induced changes in consumption habits with a focus on nonessential material consumption and mobility behavior. The survey (n=4000) was carried out in Germany, Italy, Japan, and the United States in early 2021. Our findings show early trends toward more sustainable behavior in nonessential material consumption, especially a reduction in purchases and the realization, that the unpurchased items were not missed. While there were likewise significant pandemic-related changes in mobility both concerning trip frequency and purpose and transport modes, respondents' future intentions do not suggest significant gains in sustainability in this area. Quelle: Forschungsbericht
description: This paper presents the results of a multicountry survey on Covid-19-induced changes in consumption habits with a focus on nonessential material consumption and mobility behavior. The survey was carried out in Germany, Italy, Japan, and the United States in early 2021. The findings show early trends toward more sustainable behavior in nonessential material consumption, especially a reduction in purchases and the realization, that the unpurchased items were not missed. While there were likewise significant pandemic-related changes in mobility both concerning trip frequency and purpose and transport modes, respondents’ future intentions do not suggest significant gains in sustainability in this area.