cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Βιώσιμη ανάπτυξη και οι μελλοντικές τάσεις στον τομέα της φαρμακοβιομηχανίας
title: Sustainable development and the future trends in the sector of pharmaceutical industry
titleType: AlternativeTitle
Creators: name: Βάκκας, Ηλίας
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2023
Subjects: subject: Φαρμακοβιομηχανία
subject: Βιώσιμη ανάπτυξη
subject: Φαρμακευτικές εταιρείες

description: Η έννοια της βιώσιμης ανάπτυξης αποτελεί ένα θέμα θεμελιώδους σημασίας καθώς επηρεάζει πολιτικά, γεωγραφικά, κοινωνικά και οικονομικά την υφήλιο. Η οικολογική παραγωγικότητα κρίνεται αναγκαία σε πολλά επίπεδα καθώς η περιβαλλοντική κρίση εντείνεται ανά τα έτη. Στο πλαίσιο αυτό, είναι απαραίτητη η εστίαση στην αειφορία των επιχειρηματικών οντοτήτων. Η υιοθέτηση βιώσιμων πρακτικών και στρατηγικών φιλικών προς το περιβάλλον, ιδίως στο κλάδο των φαρμακοβιομηχανιών είναι ικανή να κρατήσει σταθερή την περιβαλλοντική κρίση. Παράλληλα η βιωσιμότητα πέρα από την κερδοφορία που δύναται να εξασφαλίσει, συμβάλει στην διευκόλυνση της πρόσβασης στην εκπαίδευση, στην δίκαιη μεταχείριση και την αποφυγή στερεοτύπων. Ο συνδυασμός αυτών, έχει την ικανότητα μέσα σε ένα περιβάλλον ανταγωνιστικό και διαρκώς μεταβαλλόμενο να δημιουργήσει αξιοπρεπείς συνθήκες διαβίωσης. Ο κλάδος της φαρμακοβιομηχανίας φημίζεται για την άρρηκτη σύνδεσή του με την καινοτομία και είναι σαφές λοιπόν ότι προωθώντας βιώσιμες πρακτικές σε όλα τα επιχειρηματικά της τμήματα αποκτά ένα ισχυρό ανταγωνιστικό πλεονέκτημα, που αποφέρει μεγάλα κέρδη. Αυτό σημαίνει, ότι η βιώσιμη μέριμνα, δηλαδή η φροντίδα του περιβάλλοντος κατά την επιχειρηματική δραστηριότητα και η μείωση των ρύπων αναβαθμίζει τόσο τοπικά όσο και παγκόσμια δίνοντας το παράδειγμα για μίμηση, την καλυτέρευση της κοινωνίας και την «επούλωση» του περιβάλλοντος από τον ανθρώπινο παράγοντα.
title: Химия
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2024

description: Практикум содержит основные понятия, теоретический материал по основным разделам дисциплины «Химия», а также примеры решения типовых задач, задания для проверки усвоения изученного материала и методики проведения лабораторных работ. Соответствует требованиям Федерального государственного образовательного стандарта среднего профессионального образования, предъявляемым к изучению дисциплины «Химия». Практикум предназначен для студентов, обучающихся по профессиям и специальностям среднего профессионального образования «Технология молока и молочных продуктов», «Технология продуктов питания животного происхождения», изучающих курс «Химии».
title: Οι επιχειρησιακές στρατηγικές στην αγορά των super market & και η επιρροή των προϊόντων ιδιωτικής ετικέτας
title: The business strategies in the super market sector & the influence of private label products
titleType: AlternativeTitle
Creators: name: Μανέτας, Παναγιώτης
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2023
Subjects: subject: Σούπερ μάρκετ
subject: Προϊόντα ιδιωτικής ετικέτας
subject: Σκλαβενίτης
subject: ΑΒ Βασιλόπουλος

description: Η παρούσα διπλωματική εργασία έχει ως στόχο να διερευνήσει την εγχώρια αγορά των σούπερ μάρκετ καθώς και τις στρατηγικές που εφαρμόζουν οι κυριότερες επιχειρήσεις του κλάδου, προκειμένου να διευρύνουν το μερίδιο τους στην αγορά. Παράλληλα, αποτυπώνεται και η διαχρονική πορεία των προϊόντων ιδιωτικής ετικέτας στην ελληνική αγορά, καθώς και η διείσδυση τους στην αγορά των σούπερ μάρκετ. Ειδικότερα, παρουσιάζονται οι παράγοντες ζήτησης και η προσφορά του κλάδου. Στην συνέχεια απεικονίζεται η εξέλιξη της εγχώριας αγοράς (σε αξία) των σούπερ μάρκετ τα τελευταία τριάντα χρόνια, επ' αφορμή της οποίας παρατίθενται και οι παράγοντες που επηρέασαν τον συγκεκριμένο κλάδο. Στο ίδιο κεφάλαιο εκτιμώνται και τα μερίδια αγοράς των μεγαλύτερων επιχειρήσεων του κλάδου. Μετέπειτα, ακολουθεί χρηματοοικονομική ανάλυση των κυριότερων αλυσίδων σούπερ μάρκετ για την τετραετία 2018-2021. Ακόμη, παρουσιάζονται τα προφίλ των δύο βασικότερων εταιρειών που δραστηριοποιούνται στην εν λόγω αγορά. Παράλληλα, περιγράφονται οι βασικότερες στρατηγικές κινήσεις που εφαρμόζονται από πολλές αλυσίδες σούπερ μάρκετ προκειμένου να ανταπεξέλθουν στον ανταγωνισμό και να αναπτυχθούν περαιτέρω. Τέλος, στο πλαίσιο της ανάλυσης της εγχώριας αγοράς των προϊόντων ιδιωτικής ετικέτας, πραγματοποιήθηκε πρωτογενή έρευνα σε δείγμα 48 ατόμων, βάση ενός δομημένου ερωτηματολογίου, προκειμένου να εξεταστούν μεταξύ άλλων οι κύριοι παράγοντες που ωθούν τους καταναλωτές να αγοράσουν προϊόντα ιδιωτικής ετικέτας καθώς και οι κυριότερες κατηγορίες των εν λόγω αγαθών που προτιμούν.
Additional file 1 of Construction and preservation of a stable and highly expressed recombinant Helicobacter pylori vacuolating cytotoxin A with apoptotic activity
Creators: name: Yuan, Ling-Zhi
name: Shi, Xiao
name: Tang, Dan
name: Zheng, Shao-Peng
name: Xiao, Zhi-Ming
name: Wang, Fen
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Supplementary Figure 1. Nucleotide and deduced putative amino acid sequences of recombinant vacA toxin gene from H. pylori strain ATCC 700824.
La caratterizzazione delle collezioni museali attraverso l’analisi del rischio: applicazione del modello alla collezione d’arte etnica di Peggy Guggenheim
Creators: name: Contu, Nicolò Roberto
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2016

description: L’obiettivo principale di questo studio è quello di applicare le strategie tipiche dell’analisi del rischio al fine di elaborare un metodo di caratterizzazione e classificazione delle collezioni museali utile a semplificare e ottimizzare le operazioni di gestione delle collezioni stesse. Il secondo obiettivo prevede di applicare il metodo sopracitato ad una collezione esistente e di verificarne i benefici. E’ stata scelta come caso studio la collezione di arte etnica di Peggy Guggenheim
Large-N limits of 2d CFTs, Quivers and AdS_3 duals
Creators: name: Kiritsis, Elias
name: Niarchos, Vasilis
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We explore the large-N limits of 2d CFTs, focusing mostly on WZW models and their cosets. The $SU(N)_k$ theory is parametrized in this limit by a 't Hooft-like coupling. We show a duality between strong coupling, where the theory is described by almost free fermions, and weak coupling where the theory is described by bosonic fields by an analysis of spectra and correlators. The AdS$_3$ dual is described, and several quantitative checks are performed. Besides the more standard states that should correspond to bulk black holes we find ground states with large degeneracy that can dominate the standard Cardy entropy at weak coupling and are expected to correspond to regular horizonless semiclassical bulk solutions.
description: latex, 54pages; v2 minor changes, addition of a new appendix on YM-CS theories on AdS3, version published in JHEP; v3 several misprints have been corrected in the formulae of section 5
Erweiterung des pathophysiologischen und klinischen Spektrums der Myasthenia gravis
Creators: name: Hoffmann, Sarah
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2023
Subjects: subject: Myasthenia gravis
subject: B-cells
subject: fatigue
subject: neurophysiology
subject: pathogenesis
subject: antibodies
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Die Myasthenia gravis gilt als Prototyp einer Antikörper-vermittelten Autoimmunerkrankung mit dem Leitsymptom der belastungsabhängigen Muskelschwäche. Die Effektormechanismen der „klassischen“ AchR-Autoantikörper sind gut charakterisiert. Dies gilt jedoch nicht für die Pathomechanismen bei der seronegativen MG und auch die pathogenetischen Prozesse, welche letztendlich zur Antikörper-Produktion führen, sind weitgehend unverstanden. Die klinische Erfahrung zeigt, dass eine Reduktion der Symptomatik auf die belastungsabhängige Muskelschwäche zu kurz greift und weder das klinische Bild noch die daraus für die MG-Patient*innen resultierende Krankheitslast adäquat abbilden. Im Rahmen dieser Habilitationsschrift werden daher sowohl experimentelle als auch klinische Publikationen zusammengetragen, deren Ergebnisse sowohl das pathophysiologische als auch klinische Spektrum der MG erweitern und zu einem besseren Verständnis des „snow flake disease“ beitragen. So ist es bspw. durch den Nachweis von IgG1- und Komplementablagerungen an der neuromuskulären Endplatte gelungen, einen relevanten Beitrag zum pathophysiologischen Verständnis der seronegativen Myasthenia gravis zu leisten. Dieses Ergebnis hat bereits Einzug in die klinische Praxis im Sinne einer erweiterten Diagnostik mittels Interkostalmuskelbiopsien bei der seronegativen MG geführt. Der Nachweis einer erhöhten Frequenz von antikörperproduzierenden Plasmazellen zeigt eine pathologische Aktivierung der humoralen Immunantwort bei MG-Patient*innen. Diese war ebenfalls unter Therapie mit Langzeit-Immunsuppressiva (z.B. Azathioprin) nachweisbar, nicht jedoch unter Kortikosteroid-Therapie. Die Plasmazell-gerichteten Effekte von Kortikosteroiden könnten deren rasche und sehr zuverlässige Wirkung erklären. Eine gezielte Plasmazellinhibition (z.B. mit dem gegen CD38 gerichteten therapeutischen monoklonalen Antikörper Daratumumab) könnte daher eine zukünftige Therapiestrategie bei der MG darstellen und wurde durch uns im Falle eines therapierefraktären MG-Patienten mit hochaktiver Verlaufsform bereits erfolgreich off label eingesetzt. Die Erkenntnis einer hohen Prävalenz von Fatigue bei MG in der bis dahin größten klinischen Studie zu diesem Thema wurde seither durch weitere Studien repliziert und Fatigue wird mittlerweile als Teil des klinischen Spektrums der Myasthenia gravis akzeptiert und auch als Outcome-Parameter in Interventionsstudien untersucht. Der Nachweis einer hohen Krankheitslast bei der MG und deren Assoziation mit demographischen, sozialen, physischen und psychischen Faktoren erfordert neben den myastheniespezifischen medikamentösen Therapien auch biopsychosoziale Behandlungsstrategien, die jedoch bislang im klinischen Alltag kaum Anwendung finden.
Cross-tabulation matrices of fuel model dynamics between 2000 and 2018 in Alto Minho
Creators: name: Oliveira, Emanuel
name: Fernandes, Paulo
name: Barros, David
name: Guiomar, Nuno
Publisher: name: figshare
Year: 2023
Subjects: Agroforestry
Forest ecosystems
Forestry fire management
Forestry management and environment

description: Cross-tabulation matrices showing changes in fuel models between 2000 and 2018 in Alto Minho in all regiona, in burned areas and in seasonal and unseasonal burned areas.
Electrostatic Field Driven Alignment of Organic Oligomers on ZnO Surfaces
Creators: name: Della Sala, F.
name: Blumstengel, S.
name: Henneberger, F.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We study the physisorption of organic oligomers on the ZnO($10\bar{1}0$) surface using first-principles density-functional theory and non-empirical embedding methods. We find that both in-plane location and orientation of the molecules are completely determined by the coupling of their quadrupole moments to the periodic dipolar electric field present at the semiconductor surface. The adsorption is associated with the formation of a molecular dipole moment perpendicular to the surface, which bears an unexpected linear relation to the molecule-substrate interaction energy. Long oligomers such as sexiphenyl become well-aligned with stabilization energies of several 100 meV along rows of positive electric field, in full agreement with recent experiments. These findings define a new route towards the realization of highly-ordered self-assembled arrays of oligomers/polymers on ZnO($10\bar{1}0$) and similar surfaces.
description: 4 pages, 4 figures
Higher order extension of Löwner's theory: Operator $k$-tone functions
Creators: name: Franz, Uwe
name: Hiai, Fumio
name: Ricard, Éric
Publisher: name: arXiv
Year: 2011
Subjects: subject: Functional Analysis (math.FA)
subject: Operator Algebras (math.OA)
subject: FOS: Mathematics
subject: 47A56, 47A60, 47A63, 15A39

description: The new notion of operator/matrix $k$-tone functions is introduced, which is a higher order extension of operator/matrix monotone and convex functions. Differential properties of matrix $k$-tone functions are shown. Characterizations, properties, and examples of operator $k$-tone functions are presented. In particular, integral representations of operator $k$-tone functions are given, generalizing familiar representations of operator monotone and convex functions.
description: final version, 33 pages
Experimental study of thermoacoustic oscillations inside a small-scale power generator combustor
Creators: name: Heydarlaki, Ramin
Publisher: name: University of British Columbia
Year: 2020

description: Thermoacoustic (pressure and heat release rate) oscillations can be detrimental to the operation of engineering equipment ranging from large-scale gas turbine engines (hundreds of mega watts) to small-scale power generators (few kilo watts). The focus of this thesis is thermoacoustic oscillations occurring in the combustor of a small-scale power generator. In this combustor, circulation of exhaust gas around reacting gas is utilized to increase the combustor thermal efficiency and is facilitated by using a stagnation wall. Two experimental setups are utilized. The former is a close replication of the engineering equipment, and the latter is a simplified version of the equipment, but it provides optical accessibility. In the experiments, the fuel-air equivalence ratio and air flowrate are varied from 0.7to 1.4 and 50 to 180 SLPM, respectively. For the experiments related to the first setup, pressure and temperature measurements are performed. For the second setup, both pressure and flame chemiluminescence measurements are acquired. For the first setup, the characteristics of thermoacoustic oscillations while the wall-temperature increases and how the initial wall-temperature influences these characteristics are investigated. It is shown, that for cold-start conditions, the pressure transitions from chaotic to limit cycle, chaotic, bursting, and then limit cycle oscillations. For warm-start conditions, however, the pressure features a combination of both large- and small-amplitude limit cycle oscillations. For the second setup, contributions of different types of thermoacoustic modes to Rayleigh gain is investigated. Results show that, for fuel-air equivalence ratio of 0.7, thermoacoustic oscillations feature natural structural (21 Hz) and acoustic (61 Hz) modes. However, oscillations related to fuel-air equivalence ratio of 0.9 feature intrinsic modes near 240 and 290 Hz, in addition to structural and acoustic modes. It is demonstrated that acoustic and structural modes mostly contribute to the growth of the thermoacoustic oscillations. However, generally, intrinsic modes contribute to mitigation of the thermoacoustic oscillations by providing negative acoustic energy source term mainly near the flame holder and stagnation wall. To the best knowledge of the author, the contributions of structural and intrinsic modes to Rayleigh gain have not been investigated in the past.
title: Ð­ÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ Ð¿ÑÐ¾ÐµÐºÑÐ¾Ð² Ð² ÑÐµÐ¿Ð»Ð¾ÑÐ½Ð°Ð±Ð¶ÐµÐ½Ð¸Ð¸ Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð¼ÐµÑ Ð°Ð½Ð¸Ð·Ð¼Ð° Ð³Ð¾ÑÑÐ´Ð°ÑÑÑÐ²ÐµÐ½Ð½Ð¾-ÑÐ°ÑÑÐ½Ð¾Ð³Ð¾ Ð¿Ð°ÑÑÐ½ÐµÑÑÑÐ²Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Efficiency of projects in heat supply sphere with using the Public-Private Partnerships mechanism
Creators: name: ÐÐ»Ð°ÑÐ¾Ð², ÐÐ°Ð½Ð¸Ð¸Ð»
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: ÑÐµÐ¿Ð»Ð¾ÑÐ½Ð°Ð±Ð¶ÐµÐ½Ð¸Ðµ
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ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ Ð¿ÑÐ¾ÐµÐºÑÐ¾Ð²
ÑÐµÐ¿Ð»Ð¾ÑÐ½ÐµÑÐ³ÐµÑÐ¸ÑÐµÑÐ¸ÐºÐ¸Ð¹ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑ
ÐºÐ¾Ð½ÑÐµÑÑÐ¸Ñ
heat supply
PPP projects
project efficiency
heat and power complex
concession

description: Ð¢ÐµÐ¼Ð° Ð²ÑÐ¿ÑÑÐºÐ½Ð¾Ð¹ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ: Â«Ð­ÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ Ð¿ÑÐ¾ÐµÐºÑÐ¾Ð² Ð² ÑÐµÐ¿Ð»Ð¾ÑÐ½Ð°Ð±Ð¶ÐµÐ½Ð¸Ð¸ Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð¼ÐµÑÐ°Ð½Ð¸Ð·Ð¼Ð° ÐÐ§ÐÂ».
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 Ð Ð°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ñ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÐµ Ð¼ÐµÑÐ¾Ð´Ñ Ð°Ð½Ð°Ð»Ð¸Ð·Ð°. ÐÐ´Ð¸Ð½ Ð¸Ð· Ð¼ÐµÑÐ¾Ð´Ð¾Ð² Ð¿ÑÐ¸Ð¼ÐµÐ½ÑÐ½ Ð½Ð° Ð¿ÑÐ°ÐºÑÐ¸ÐºÐµ Ð¿ÑÐ¸ Ð½Ð°ÑÐ¾Ð¶Ð´ÐµÐ½Ð¸Ð¸ Ð¾Ð¿ÑÐ¸Ð¼Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ Ð²Ð°ÑÐ¸Ð°Ð½ÑÐ° ÑÐµÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ ÐºÐ¾Ð½ÑÑÐ°ÐºÑÐ¾Ð² Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ ÐÐ§Ð. ÐÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ñ Ð²ÑÐµ Ð½ÐµÐ¾Ð±ÑÐ¾Ð´Ð¸Ð¼ÑÐµ ÑÐ°ÑÑÑÑÑ. ÐÐ° Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð¸Ð¸ ÑÐ°ÑÑÑÑÐ¾Ð² Ð¿ÑÐ¾Ð²ÐµÐ´ÑÐ½ Ð°Ð½Ð°Ð»Ð¸Ð· Ð¸ Ð²ÑÐ±ÑÐ°Ð½Ð° Ð¾Ð¿ÑÐ¸Ð¼Ð°Ð»ÑÐ½Ð°Ñ Ð°Ð»ÑÑÐµÑÐ½Ð°ÑÐ¸Ð²Ð°.
description: The subject of the graduate qualification work is "Efficiency of projects in heat supply sphere with using the PPP mechanism".
 The object of research is PK âEnergyâ LLC.
 The paper presents a review of multicriteria analysis methods and the application of one of them in a real case.
 A review of theoretical aspects and legal regulation of energy sector. The article presents an analysis of St. Petersburg' energy sector, its current state and development prospects.
 Various methods of analysis are considered. One of the methods was applied in practice when finding the best option for implementing contracts using PPP. All necessary calculations are presented. Based on the calculations, an analysis is carried out and the optimal alternative is selected.
The comfortable roller coaster -- on the shape of tracks with constant normal force
Creators: name: Nordmark, Arne B.
name: Essen, Hanno
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mathematical Physics (math-ph)
subject: Classical Physics (physics.class-ph)
subject: FOS: Physical sciences

description: A particle that moves along a smooth track in a vertical plane is influenced by two forces: gravity and normal force. The force experienced by roller coaster riders is the normal force, so a natural question to ask is: what shape of the track gives a normal force of constant magnitude? Here we solve this problem. It turns out that the solution is related to the Kepler problem; the trajectories in velocity space are conic sections.
description: 10 pages, 4 figures
Alberi dello stesso bosco: un progetto sulle identità competenti per favorire il benessere in classe dei bambini alla scuola dell'infanzia
Creators: name: Carina, Prisca
Publisher: name: Scuola Universitaria della Svizzera Italiana (SUPSI)
Year: 2020
Subjects: benessere
identità competenti
narrazione di sé
interessi
gruppo

description: Questo lavoro propone un percorso sulla narrazione di sé e sulla scoperta delle proprie identità competenti da parte dei bambini, con l’intento di migliorare il benessere in classe. Si è voluto includere maggiormente alcuni allievi nel gruppo attraverso la valorizzazione dei loro punti forti per metterli a disposizione dei compagni. La scelta del tema verte su più fattori: uno di questi è l’osservazione di dinamiche che ostacolavano l’inclusione di alcuni bambini nel gruppo classe. La ricerca è stata svolta adottando un approccio di tipo qualitativo, utilizzando quali strumenti d’indagine delle griglie d’osservazione per i bambini monitorati e il diario di bordo per tutto il gruppo. Con questo lavoro ho potuto constatare dei miglioramenti sia a livello individuale che di gruppo, sia sul piano relazionale che emotivo. La classe ha imparato a conoscersi, accettare le diversità includendole nella vita scolastica di tutti i giorni. La conoscenza di sé e dell’altro è risultata essere un pilastro fondamentale del vivere insieme e dell’apprendimento in generale. Relatrice: Veronica Simona Benhamza.
Additional file 1 of Insights into glycosidic bond specificity of an engineered selective α-L-rhamnosidase N12-Rha via activity assays and molecular modelling
Creators: name: Yu, Bo
name: Luo, Shiyu
name: Ding, Yuhan
name: Gong, Zijie
name: Nie, Ting
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Fig.S1. A PCR amplification of α-L-rhamnosidase gene from 11 positive clones (N1, N4, N5, N6, N8, N10, N12, N13,N14, N24 and N28). B SDS-PAGE analysis of N-glycosidase F treated N12-Rha.Lane 1, untreated N12-Rha; lane 2, N12-Rha treated with N-Glycosidase F. Fig.S2. Ramachandran plot A and Verify-3D B of N12-Rha model
title: PERSPECTIVES ON USING TOOLS TO CONTROL POLYPHARMACY  IN PSYCHIATRIC PATIENTS
Creators: name: Kirilochev, Oleg O.
name: Umerova, Adelya R.
Publisher: name: Astrakhan State Medical University
Year: 2021

description: Abstract. The study aimed to evaluate the risk of developing adverse drug reactions in patients aged 65 years and older who received drug treatment for mental disorders. The analysis demonstrated the potential of specific tools for assessing drug therapy appropriateness in a mental health setting. An assessment using «Trigger Tool for Measuring Adverse Drug Events in a Mental Health Setting» and «The GerontoNet ADR Risk Score» showed that more than half of hospitalized elderly patients are at risk of adverse reactions. In the majority of cases, this risk was associated with two major factors characterizing drug therapy in the study group: age and psychopharmacotherapy. These results high-light the importance of careful control over drug therapy safety in patients aged 65 years and older and therapy optimization when a high risk of adverse drug events is identified.
Key words: global trigger tool, the GerontoNet ADR risk score, adverse drug reactions, polypharmacy
title: ÐÐµÐ»Ð¸Ð½ÐµÐ¹Ð½Ð°Ñ Ð´Ð¸Ð½Ð°Ð¼Ð¸ÐºÐ° ÑÑÐ²ÑÑÐ²Ð¸ÑÐµÐ»ÑÐ½Ð¾Ð³Ð¾ ÑÐ»ÐµÐ¼ÐµÐ½ÑÐ° Ð°ÑÐ¾Ð¼Ð½Ð¾Ð³Ð¾ ÑÐ¸Ð»Ð¾Ð²Ð¾Ð³Ð¾ Ð¼Ð¸ÐºÑÐ¾ÑÐºÐ¾Ð¿Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Nonlinear dynamics of the sensitive element of an atomic force microscope
Creators: name: Ð£Ð´Ð°Ð»Ð¾Ð², ÐÐ°Ð²ÐµÐ»
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2019
Subjects: Ð¼Ð¸ÐºÑÐ¾ÑÐºÐ¾Ð¿Ð¸Ñ
Ð°ÑÐ¸Ð¼Ð¿ÑÐ¾ÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð¼ÐµÑÐ¾Ð´Ñ
Ð¼ÐµÑ Ð°Ð½Ð¸ÐºÐ°
Ð¼ÐµÑÐ¾Ð´ Ð¼Ð½Ð¾Ð³Ð¸Ñ Ð¼Ð°ÑÑÑÐ°Ð±Ð¾Ð²
Ð¼ÐµÑÐ¾Ð´ Ð¿ÑÑÐ¼Ð¾Ð¹ Ð°ÑÐ°ÐºÐ¸
Ð¿ÐµÑÐ¸Ð¾Ð´Ð¸ÑÐµÑÐºÐ¸Ðµ Ð´Ð²Ð¸Ð¶ÐµÐ½Ð¸Ñ
ÑÑÐ±Ð³Ð°ÑÐ¼Ð¾Ð½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐµÐ·Ð¾Ð½Ð°Ð½Ñ
microscopy
asymptotic methods
mechanics
multi-scales method
direct attack method
periodic movements
subharmonic resonance

description: Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð±ÑÐ» ÑÐ°ÑÑÐ¼Ð¾ÑÑÐµÐ½ Ð¿ÑÐ¸Ð½ÑÐ¸Ð¿ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð°ÑÐ¾Ð¼Ð½Ð¾Ð³Ð¾ ÑÐ¸Ð»Ð¾Ð²Ð¾Ð³Ð¾ Ð¼Ð¸ÐºÑÐ¾ÑÐºÐ¾Ð¿Ð° Ð² ÐºÐ¾Ð½ÑÐ°ÐºÑÐ½Ð¾Ð¼ ÑÐµÐ¶Ð¸Ð¼Ðµ Ð¿ÑÐ¸ Ð¾ÑÐ½Ð¾Ð²Ð½Ð¾Ð¼ Ð¸ ÑÑÐ±Ð³Ð°ÑÐ¼Ð¾Ð½Ð¸ÑÐµÑÐºÐ¾Ð¼ ÑÐµÐ·Ð¾Ð½Ð°Ð½ÑÐ°Ñ. Ð Ð¿ÑÐ¾ÑÐµÑÑÐµ ÑÐ°Ð±Ð¾ÑÑ Ð±ÑÐ»Ð¸ Ð¿Ð¾Ð»ÑÑÐµÐ½Ñ Ð°Ð½Ð°Ð»Ð¸ÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÐ¸, Ð¿Ð¾ÑÑÑÐ¾ÐµÐ½Ð½ÑÐµ Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ Ð¼ÐµÑÐ¾Ð´Ð° Ð¼Ð½Ð¾Ð³Ð¸Ñ Ð¼Ð°ÑÑÑÐ°Ð±Ð¾Ð², Ð°Ð¼Ð¿Ð»Ð¸ÑÑÐ´Ñ Ð¸ ÑÐ°ÑÑÐ¾ÑÑ ÐºÐ¾Ð»ÐµÐ±Ð°Ð½Ð¸Ð¹ ÑÑÐ²ÑÑÐ²Ð¸ÑÐµÐ»ÑÐ½Ð¾Ð³Ð¾ ÑÐ»ÐµÐ¼ÐµÐ½ÑÐ° Ð°ÑÐ¾Ð¼Ð½Ð¾Ð³Ð¾ ÑÐ¸Ð»Ð¾Ð²Ð¾Ð³Ð¾ Ð¼Ð¸ÐºÑÐ¾ÑÐºÐ¾Ð¿Ð° Ð¾Ñ ÑÐµÐ»ÑÐµÑÐ° Ð¸ÑÑÐ»ÐµÐ´ÑÐµÐ¼Ð¾Ð³Ð¾ Ð¾Ð±ÑÐ°Ð·ÑÐ°. Ð¢Ð°Ðº Ð¶Ðµ Ð±ÑÐ»Ð¾ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¾ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ðµ Ð°Ð½Ð°Ð»Ð¸ÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¸ ÑÐ¸ÑÐ»ÐµÐ½Ð½ÑÑ ÑÐµÑÐµÐ½Ð¸Ð¹ Ð´Ð»Ñ ÑÐ¾Ð±ÑÑÐ²ÐµÐ½Ð½ÑÑ ÑÐ°ÑÑÐ¾Ñ ÐºÐ¾Ð»ÐµÐ±Ð°Ð½Ð¸Ð¹ Ð¸ ÐÐ§Ð¥ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸ÐºÐ¸ ÐºÐ°Ð½ÑÐ¸Ð»ÐµÐ²ÐµÑÐ° Ð² Ð¾Ð±Ð¾Ð¸Ñ ÑÐ»ÑÑÐ°ÑÑ.
description: This paper was considered by the action principle of atomic force microscope in contact mode, when the principal and subharmonic resonances. In the course of work the analytical dependences were built using the multi-scale, amplitude and frequency of the sensitive element of the atomic force microscope from the topography of the sample. So was the comparison of analytical and numerical solutions for natural frequencies of oscillation and frequency-response characteristics of cantilever in both cases.
Measurement of the $η\to 3π^{0}$ slope parameter $α$ with the KLOE detector
Creators: name: Ambrosino, F.
name: Antonelli, A.
name: Antonelli, M.
name: Archilli, F.
name: Beltrame, P.
name: Bencivenni, G.
name: Bini, C.
name: Bloise, C.
name: Bocchetta, S.
name: Bossi, F.
name: Branchini, P.
name: Campana, P.
name: Capon, G.
name: Capussela, T.
name: Ceradini, F.
name: Ciambrone, P.
name: De Lucia, E.
name: De Santis, A.
name: De Simone, P.
name: De Zorzi, G.
name: Denig, A.
name: Di Domenico, A.
name: Di Donato, C.
name: Di Micco, B.
name: Dreucci, M.
name: Felici, G.
name: Ferrari, A.
name: Fiore, S.
name: Franzini, P.
name: Gatti, C.
name: Gauzzi, P.
name: Giovannella, S.
name: Jacewicz, M.
name: Kluge, W.
name: Kulikov, V.
name: Lee-Franzini, J.
name: Martini, M.
name: Massarotti, P.
name: Meola, S.
name: Miscetti, S.
name: Moulson, M.
name: Müller, S.
name: Murtas, F.
name: Napolitano, M.
name: Nguyen, F.
name: Palutan, M.
name: Passeri, A.
name: Patera, V.
name: Perfetto, F.
name: Santangelo, P.
name: Sciascia, B.
name: Sciubba, A.
name: Spadaro, T.
name: Taccini, C.
name: Tortora, L.
name: Valente, P.
name: Venanzoni, G.
name: Versaci, R.
name: Xu, G.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We present a measurement of the slope parameter $α$ for the $η\to 3π^{0}$ decay, with the KLOE experiment at the DA$Φ$NE $ϕ$-factory, based on a background free sample of $\sim$ 17 millions $η$ mesons produced in $ϕ$ radiative decays. By fitting the event density in the Dalitz plot we determine $α= -0.0301 \pm 0.0035\,stat\;_{-0.0035}^{+0.0022}\,syst\,$. The result is in agreement with recent measurements from hadro- and photo-production experiments.
description: 14 pages, 11 figures
The Clinical Significance of Simultaneous IL-17A and IL-17F Blockade in Psoriasis Non-Responding to Anti-IL17A Therapy
Creators: name: Kokolakis, Georgios
name: Ghoreschi, Kamran
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: psoriasis
subject: scalp psoriasis
subject: psoriasis arthritis
subject: bimekizumab
subject: IL-17
subject: IL-23
subject: TNFalpha
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: The better understanding of the immunopathogenesis of psoriasis has led to the development of highly efficacious targeted therapies with favorable safety profiles. Among them, the class of Interleukin (IL)-17 antibodies are well established for the treatment of psoriasis, psoriatic arthritis and axial spondyloarthritis. Bimekizumab is a new antibody that simultaneously neutralizes IL-17A and IL-17F. We present two patients with psoriasis, who lost response to several biologics, among them IL-17 antagonists such as secukinumab, ixekizumab or brodalumab. Besides plaque-type psoriasis, patients also had psoriasis in hard-to-treat areas such as scalp and groins or psoriatic arthritis. Remarkably, both patients already responded to the therapy with bimekizumab 4 weeks after the first injection and, one year thereafter, both patients sustained PASI100. No side effects were observed. The fast response to bimekizumab emphasizes the crucial role of IL-17F in the pathogenesis of psoriasis. Besides, due to the new mechanism of action, non-responders to other anti-IL-17 therapies could benefit when switched to bimekizumab.
title: ÐÐ´ÑÐ¾Ð½Ð½ÑÐµ ÑÑÑÑÐ¸ Ð½Ð° Ð°Ð´ÑÐ¾Ð½-Ð°Ð´ÑÐ¾Ð½Ð½ÑÑ ÐºÐ¾Ð»Ð»Ð°Ð¹Ð´ÐµÑÐ°Ñ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Hadron jets in hadron-hadron colliders
Creators: name: ÐÐ²ÑÑÑÐ¾Ð², ÐÐ»ÐµÐºÑÐ°Ð½Ð´Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2019
Subjects: ÐÐ¾Ð½ÑÐµ-ÐÐ°ÑÐ»Ð¾ Ð¼ÐµÑÐ¾Ð´
Ð£ÑÐºÐ¾ÑÐ¸ÑÐµÐ»Ð¸ Ð·Ð°ÑÑÐ¶ÐµÐ½Ð½ÑÑ ÑÐ°ÑÑÐ¸Ñ
ÐÐ²Ð°ÑÐºÐ¸
Ð­Ð»ÐµÐ¼ÐµÐ½ÑÐ°ÑÐ½ÑÐµ ÑÐ°ÑÑÐ¸ÑÑ
Ð°Ð´ÑÐ¾Ð½Ð½Ð¾Ðµ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ
Ð³ÐµÐ½ÐµÑÐ°ÑÐ¾ÑÑ ÑÐ¾Ð±ÑÑÐ¸Ð¹
Ð¶ÐµÑÑÐºÐ¾Ðµ ÑÐ°ÑÑÐµÐ¸Ð²Ð°Ð½Ð¸Ðµ
ÐºÐ¾Ð»Ð»Ð°Ð±Ð¾ÑÐ°ÑÐ¸Ñ D0
ÑÐµÑÐµÐ½Ð¸Ðµ ÑÐ¾Ð¶Ð´ÐµÐ½Ð¸Ñ ÑÑÑÑÐ¹

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¸ Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ Ð¿ÑÐ¾ÑÐµÑÑÐ¾Ð² Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ñ Ð°Ð´ÑÐ¾Ð½Ð½ÑÑ ÑÑÑÑÐ¹ Ð½Ð° Ð°Ð´ÑÐ¾Ð½Ð½ÑÑ ÐºÐ¾Ð»Ð»Ð°Ð¹Ð´ÐµÑÐ°Ñ Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ ÑÐ°Ðº Ð½Ð°Ð·ÑÐ²Ð°ÐµÐ¼ÑÑ ÐÐ¾Ð½ÑÐµ-ÐÐ°ÑÐ»Ð¾ Ð³ÐµÐ½ÐµÑÐ°ÑÐ¾ÑÐ¾Ð² ÑÐ¾Ð±ÑÑÐ¸Ð¹, ÐºÐ¾ÑÐ¾ÑÑÐµ Ð¿Ð¾Ð²ÑÐµÐ¼ÐµÑÑÐ½Ð¾ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·ÑÑÑÑÑ Ð²Ð¾ Ð²ÑÐµÑ ÑÑÐ°Ð´Ð¸ÑÑ ÑÐ¾Ð²ÑÐµÐ¼ÐµÐ½Ð½ÑÑ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ¾Ð². ÐÐ·ÑÑÐµÐ½Ð¸Ðµ ÑÑÑÑÐ¹ Ð¿Ð¾Ð·Ð²Ð¾Ð»ÑÐµÑ Ð¿ÑÐ¾Ð½Ð¸ÐºÐ½ÑÑÑ Ð² ÑÐ°Ð¼Ñ ÑÑÑÑ ÐÐ²Ð°Ð½ÑÐ¾Ð²Ð¾Ð¹ Ð¥ÑÐ¾Ð¼Ð¾Ð´Ð¸Ð½Ð°Ð¼Ð¸ÐºÐ¸ (ÐÐ¥Ð) Ð¸ ÑÐ²Ð»ÑÐµÑÑÑ Ð¼Ð¾ÑÐ½ÑÐ¼ Ð¸Ð½ÑÑÑÑÐ¼ÐµÐ½ÑÐ¾Ð¼ Ð¿ÑÐ¸ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¸ ÑÐ¸Ð·Ð¸ÐºÐ¸ ÑÐ»ÐµÐ¼ÐµÐ½ÑÐ°ÑÐ½ÑÑ ÑÐ°ÑÑÐ¸Ñ. Ð ÑÐ°Ð±Ð¾ÑÐµ ÑÐ¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ñ Ð¸Ð½ÐºÐ»ÑÐ·Ð¸Ð²Ð½ÑÐµ ÑÐµÑÐµÐ½Ð¸Ñ ÑÐ¾Ð¶Ð´ÐµÐ½Ð¸Ñ ÑÑÑÑÐ¹ Ð¿ÑÐ¸ ÑÑÐ¾Ð»ÐºÐ½Ð¾Ð²ÐµÐ½Ð¸ÑÑ Ð¿ÑÐ¾ÑÐ¾Ð½Ð° Ð¸ Ð°Ð½ÑÐ¸Ð¿ÑÐ¾ÑÐ¾Ð½Ð° Ñ ÑÐ½ÐµÑÐ³Ð¸ÐµÐ¹ Ð² ÑÐ¸ÑÑÐµÐ¼Ðµ ÑÐµÐ½ÑÑÐ° Ð¼Ð°ÑÑ ÑÑÐ°Ð»ÐºÐ¸Ð²Ð°ÑÑÐ¸ÑÑÑ Ð°Ð´ÑÐ¾Ð½Ð¾Ð² 630 ÐÑÐ Ð¸ 1800 ÐÑÐ Ð´Ð»Ñ ÐºÐ¾Ð½ÑÑÐ½Ð¾Ð³Ð¾ Ð¸ Kt Ð°Ð»Ð³Ð¾ÑÐ¸ÑÐ¼Ð° Ð²Ð¾ÑÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð¸Ñ ÑÑÑÑÐ¹. Ð ÑÐ°Ð±Ð¾ÑÐµ ÑÑÐ°Ð²Ð½Ð¸Ð²Ð°ÑÑÑÑ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ñ Ð´Ð°Ð½Ð½ÑÐ¼Ð¸ ÐºÐ¾Ð»Ð»Ð°Ð±Ð¾ÑÐ°ÑÐ¸Ð¸ D0.
description: This work is devoted to the modeling and study of the formation of hadron jets at hadron colliders using the so-called Monte Carlo event generators, which are widely used in all stages of modern experiments. Results of calculation compared with the D0 collaboration data.
Black Hole Mass Limits for Optically Dark X-ray Bright Sources in Elliptical Galaxies
Creators: name: Jithesh, V.
name: Jeena, K.
name: Misra, R.
name: Ravindranath, S.
name: Dewangan, G. C.
name: Ravikumar, C. D.
name: Babu, B. R. S.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Estimation of the black hole mass in bright X-ray sources of nearby galaxies is crucial to the understanding of these systems and their formation. However, the present allowed black hole mass range spans five order of magnitude (10Msun < M < 10^5 Msun) with the upper limit obtained from dynamical friction arguments. We show that the absence of a detectable optical counterpart for some of these sources, can provide a much more stringent upper limit. The argument is based only on the assumption that the outer regions of their accretion disks is a standard one. Moreover, such optically dark X-ray sources cannot be foreground stars or background active galactic nuclei, and hence must be accreting systems residing within their host galaxies. As a demonstration we search for candidates among the point-like X-ray sources detected with Chandra in thirteen nearby elliptical galaxies. We use a novel technique to search for faint optical counterparts in the HST images whereby we subtract the bright galaxy light based on isophotal modeling of the surface brightness. We show that for six sources with no detectable optical emission at the 3$-$sigma level, their black hole masses M_{BH} < 5000Msun. In particular, an ultra-luminous X-ray source (ULX) in NGC 4486 has M_{BH} < 1244 Msun. We discuss the potential of this method to provide stringent constraints on the black hole masses, and the implications on the physical nature of these sources.
description: 11 Pages, 1 figure, Accepted for publication in ApJ
Paradigmatic Approach to Support Personalized Counseling With Digital Health (iKNOW)
Creators: name: Speiser, Dorothee
name: Heibges, Maren
name: Besch, Laura
name: Hilger, Caren
name: Keinert, Marie
name: Klein, Katharina
name: Rauwolf, Gudrun
name: Schmid, Christine
name: Schulz-Niethammer, Sven
name: Stegen, Steffi
name: Westfal, Viola
name: Witzel, Isabell
name: Zang, Benedikt
name: Kendel, Friederike
name: Feufel, Markus A
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2023
Subjects: subject: BRCA
subject: breast cancer
subject: cancer risk
subject: digital health
subject: genetic counseling
subject: hereditary breast and ovarian cancer
subject: hereditary cancer
subject: online counseling tool
subject: ovarian cancer
subject: risk communication
subject: user-centered design principles
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: iKNOW is the first evidence-based digital tool to support personalized counseling for women in Germany with a hereditary cancer risk. The counseling tool is designed for carriers of pathogenic gBRCA (germline breast cancer gene) variants that increase the lifetime risk of breast and ovarian cancer. Carriers of pathogenic variants are confronted with complex, individualized risk information, and physicians must be able to convey this information in a comprehensible way to enable preference-sensitive health decisions. In this paper, we elaborate on the clinical, regulatory, and practical premises of personalized counseling in Germany. By operationalizing these premises, we formulate 5 design principles that, we suggest, are specific enough to develop a digital tool (eg, iKNOW), yet wide-ranging enough to inform the development of counseling tools for personalized medicine more generally: (1) digital counseling tools should implement the current standard of care (eg, based on guidelines); (2) digital counseling tools should help to both standardize and personalize the counseling process (eg, by enabling the preference-sensitive selection of counseling contents from a common information base); (3) digital counseling tools should make complex information easy to access both cognitively (eg, by using evidenced-based risk communication formats) and technically (eg, by means of responsive design for various devices); (4) digital counseling tools should respect the counselee's data privacy rights (eg, through strict pseudonymization and opt-in consent); and (5) digital counseling tools should be systematically and iteratively evaluated with the users in mind (eg, using formative prototype testing to ensure a user-centric design and a summative multicenter, randomized controlled trial). On the basis of these paradigmatic design principles, we hope that iKNOW can serve as a blueprint for the development of more digital innovations to support personalized counseling approaches in cancer medicine.
title: Ð¡Ð¾Ð±ÑÑÐ¸Ð¹Ð½ÑÐµ ÐºÐ¾Ð¼Ð¼ÑÐ½Ð¸ÐºÐ°ÑÐ¸Ð¸ Ð² Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ Ð¼Ð¾Ð»Ð¾Ð´ÐµÐ¶Ð½ÑÑ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¹ (Ð½Ð° Ð¿ÑÐ¸Ð¼ÐµÑÐµ Ð¿Ð¾Ð´ÑÐ¾ÑÑÐºÐ¾Ð²Ð¾-Ð¼Ð¾Ð»Ð¾Ð´ÑÐ¶Ð½Ð¾Ð³Ð¾ ÑÐµÐ½ÑÑÐ° Â«ÐÐ°Ð»Ð¸Ð½Ð¸Ð½ÑÐºÐ¸Ð¹Â»)
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Event Communications in the Activities of Youth Organizations (on the Example of the Kalininskiy Teen and Youth Center)
Creators: name: Ð§Ð¸Ð±Ð¸ÑÑÐºÐ¾Ð²Ð°, Ð¡Ð¾ÑÑÑ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: ÑÐ¾Ð±ÑÑÐ¸Ð¹Ð½ÑÐµ ÐºÐ¾Ð¼Ð¼ÑÐ½Ð¸ÐºÐ°ÑÐ¸Ð¸
Ð¿Ð¾Ð´ÑÐ¾ÑÑÐºÐ¾Ð²Ð¾-Ð¼Ð¾Ð»Ð¾Ð´ÐµÐ¶Ð½Ð°Ñ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ñ
Ð¼Ð¾Ð»Ð¾Ð´ÐµÐ¶Ñ
event communications
teenage and youth organization
youth

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° ÑÐµÐ¼Ðµ ÑÐ¾Ð±ÑÑÐ¸Ð¹Ð½ÑÑ ÐºÐ¾Ð¼Ð¼ÑÐ½Ð¸ÐºÐ°ÑÐ¸Ð¹. Ð Ð²ÑÐ¿ÑÑÐºÐ½Ð¾Ð¹ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð¿Ð¾Ð´ÑÐ¾Ð±Ð½Ð¾ Ð¾Ð¿Ð¸ÑÑÐ²Ð°ÐµÑÑÑ ÐºÐ°Ðº ÑÐ¾Ð±ÑÑÐ¸Ð¹Ð½ÑÐµ ÐºÐ¾Ð¼Ð¼ÑÐ½Ð¸ÐºÐ°ÑÐ¸Ð¸ Ð¿Ð¾Ð¼Ð¾Ð³Ð°ÑÑ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¿Ð¾Ð²ÑÑÐ¸ÑÑ ÑÐ·Ð½Ð°Ð²Ð°ÐµÐ¼Ð¾ÑÑÑ Ð±ÑÐµÐ½Ð´Ð°.
description: This work is devoted to the topic of event communications. The final thesis describes in detail how event communications help an organization increase brand awareness.
Triangle groups, automorphic forms, and torus knots
Creators: name: Tsanov, Valdemar V.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Geometric Topology (math.GT)
subject: Algebraic Geometry (math.AG)
subject: Complex Variables (math.CV)
subject: FOS: Mathematics

description: This paper's theme is the relation between several classical and well-known objects: triangle Fuchsian groups, quasi-homogeneous singularities of plane curves, torus knot complements in the 3-sphere. Torus knots are the only nontrivial knots whose complements admit transitive Lie group actions. In fact S^3\K_{p,q} is diffeomorphic to a coset space of the universal covering group of PSL_2(R) with respect to a discrete subgroup G contained in the preimage of a (p,q,\infty)-triangle Fuchsian group. The existence of such a diffeomorphism between is known from a general topological classification of Seifert fibred 3-manifolds. Our goal is to construct an explicit diffeomorphism using automorphic forms. Such a construction is previously known for the trefoil knot K_{2,3} and in fact S^3\K_{2,3} = SL_2(R)/SL_2(Z). The connection between the two sides of the diffeomorphism comes via singularities of plane curves.
description: Published version
Nuclei as near BPS-Skyrmions
Creators: name: Bonenfant, Eric
name: Marleau, Luc
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study a generalization of the Skyrme model with the inclusion of a sixth-order term and a generalized mass term. We first analyze the model in a regime where the nonlinear sigma and Skyrme terms are switched to zero which leads to well-behaved analytical BPS-type solutions. Adding contributions from the rotational energy, we reproduce the mass of the most abundant isotopes to rather good accuracy. These BPS-type solutions are then used to compute the contributions from the nonlinear sigma and Skyrme terms when these are switched on. We then adjust the four parameters of the model using two different procedures and find that the additional terms only represent small perturbations to the system. We finally calculate the binding energy per nucleon and compare our results with the experimental values.
description: 12 pages, 1 figure
title: Общая химия
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2024

description: В учебном пособии представлены классификация и номенклатура неорганических соединений, основные понятия и стехиометрические законы химии, строение атома, химическая связь и энергетика химических процессов, химическая кинетика, химическое равновесие. Рассмотрены также растворы и их физико-химические свойства, электролитическая диссоциация, молекулярно-ионные уравнения обменных реакций между растворами электролитов, ионное произведение воды, гидролиз солей, произведение растворимости, условие образования осадков, комплексные соединения. Описаны окислительно-восстановительные реакции, электрохимические процессы и электролиз. Подготовлено в соответствии с требованиями Федерального государственного образовательного стандарта высшего образования. Учебное пособие предназначено для студентов, обучающихся по направлению подготовки «Промышленная экология и биотехнологии», изучающих дисциплину «Общая химия и основы химического анализа», а также будет полезно студентам других направлений подготовки и специальностей, изучающим данную дисциплину.
The Association between Neoadjuvant Radio-Chemotherapy and Prolonged Healing of Anastomotic Leakage after Esophageal Resection Treated with EndoVAC Therapy
Creators: name: Seika, Philippa
name: Biebl, Matthias
name: Raakow, Jonas
name: Berndt, Nadja
name: Feldbrügge, Linda
name: Maurer, Max Magnus
name: Dobrindt, Eva
name: Thuss-Patience, Peter
name: Pratschke, Johann
name: Denecke, Christian
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: esophageal surgery
subject: endoscopic vacuum therapy (EVT)
subject: anastomotic leakage
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: (1) Background: Endoscopic vacuum therapy (EVT) has become the mainstay in the treatment of early anastomotic leakage (AL) after esophageal resection. The effect of nRCT on the efficacy of EVT is currently unknown. (2) Methods: Data of 427 consecutive patients undergoing minimally invasive esophagectomy between 2013 and 2022 were analyzed. A total of 26 patients received EVT for AL after esophagectomy between 2010 and 2021. We compared a cohort of 13 patients after treatment with EVT for anastomotic leakage after neoadjuvant radiochemotherapy (nRCT) with a control group of 13 patients after neoadjuvant chemotherapy (nCT) using inverse propensity score weighting to adjust for baseline characteristics between the groups. EVT therapy was assessed regarding patient survival, treatment failure as defined by a change in treatment to stent/operation, duration of treatment, and secondary complications. Statistical analysis was performed using linear regression analysis. (3) Results: Time to EVT after initial tumor resection did not vary between the groups. The duration of EVT was longer in patients after nRCT (14.69 days vs. 20.85 days, p = 0.002) with significantly more interventions (4.38 vs. 6.85, p = 0.001). The success rate of EVT did not differ between the two groups (nCT n = 8 (61.54%) vs. nCT n = 5 (38.46%), p = 0.628). The rate of operative revision did not vary between the groups. Importantly, no mortality was reported within 30 days and 90 days in both groups. (4) Conclusions: EVT is a valuable tool for the management of AL after esophageal resection in patients after nRCT. While the success rates were comparable, EVT was associated with a significantly longer treatment duration. Anastomotic leakages after nRCT often require prolonged and multimodal treatment strategies while innovative strategies such as prophylactic endoVAC placement or use of a VAC-Stent may be considered.
title: Sprayable UHPC for Repair and Preservation [TechNote]
Creators: name: McDonagh, Michael
name: Sakellos, George
name: Engineering & Software Consultants, Inc.
name: Rao Research and Consulting (United States)
Publisher: name: Turner-Fairbank Highway Research Center
publisherIdentifier: https://ror.org/04edx5729
publisherIdentifierScheme: ROR
Year: 2024
Subjects: classificationCode: https://trt.trb.org/term/95125
subject: Ultra high performance concrete
classificationCode: https://trt.trb.org/term/95133
subject: Fiber reinforced concrete
classificationCode: https://trt.trb.org/term/92400
subject: Bridges
classificationCode: https://trt.trb.org/term/95819
subject: Durability
classificationCode: https://trt.trb.org/term/95116
subject: Shotcrete
classificationCode: https://trt.trb.org/term/92399
subject: Bridges and culverts
classificationCode: https://trt.trb.org/term/92356
subject: Tunnels

description: This TechNote presents some of the successes of sprayed ultra-high performance concrete (UHPC) in Europe and the United States and discusses some of the challenges of using it, thus aiming to encourage and facilitate its adoption in the United States. This technology shows great promise, given its potential to lower UHPC placement costs and enable new applications that can benefit from the properties of UHPC.
title: ÐÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð¸ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¸Ð½ÑÑÑÑÐ¼ÐµÐ½ÑÐ° Ð´Ð»Ñ Ð°Ð²ÑÐ¾Ð¼Ð°ÑÐ¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð³Ð¾ ÑÐµÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ web-ÑÐµÑÐ²Ð¸ÑÐ°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Design and development of a tool for automated testing of web-service
Creators: name: ÐÐ°Ð±Ð°Ð½Ð¾Ð²Ð°, Ð¡Ð²ÐµÑÐ»Ð°Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2019
Subjects: Ð°Ð²ÑÐ¾Ð¼Ð°ÑÐ¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ðµ ÑÐµÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ
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ÑÑÐµÐ¹Ð¼Ð²Ð¾ÑÐº
automated testing
web-service
testing tool
framework

description: Ð¦ÐµÐ»Ñ ÑÐ°Ð±Ð¾ÑÑ - ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° ÑÑÐµÐ¹Ð¼Ð²Ð¾ÑÐºÐ° Ð´Ð»Ñ Ð°Ð²ÑÐ¾Ð¼Ð°ÑÐ¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð³Ð¾ ÑÐµÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð²ÐµÐ±-ÑÐµÑÐ²Ð¸ÑÐ° Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Selenium Ð¸ Java, Ð½Ð° ÐºÐ¾ÑÐ¾ÑÐ¾Ð¼ Ð¼Ð¾Ð¶Ð½Ð¾ Ð±ÑÑÑÑÐ¾ Ð¸ Ð»ÐµÐ³ÐºÐ¾ Ð¿Ð¸ÑÐ°ÑÑ ÑÐµÑÑÐ¾Ð²ÑÐµ ÑÑÐµÐ½Ð°ÑÐ¸Ð¸ Ð´Ð»Ñ ÑÐµÐ³ÑÐµÑÑÐ¸Ð¾Ð½Ð½Ð¾Ð³Ð¾ ÑÐµÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ.
description: The goal of the work is to develop a framework for automated testing of a web service based on Selenium and Java, where you can quickly and easily write test scripts for regression testing.
Pivotal estimation via square-root Lasso in nonparametric regression
Creators: name: Belloni, Alexandre
name: Chernozhukov, Victor
name: Wang, Lie
Publisher: name: arXiv
Year: 2011
Subjects: subject: Methodology (stat.ME)
subject: Statistics Theory (math.ST)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: We propose a self-tuning $\sqrt{\mathrm {Lasso}}$ method that simultaneously resolves three important practical problems in high-dimensional regression analysis, namely it handles the unknown scale, heteroscedasticity and (drastic) non-Gaussianity of the noise. In addition, our analysis allows for badly behaved designs, for example, perfectly collinear regressors, and generates sharp bounds even in extreme cases, such as the infinite variance case and the noiseless case, in contrast to Lasso. We establish various nonasymptotic bounds for $\sqrt{\mathrm {Lasso}}$ including prediction norm rate and sparsity. Our analysis is based on new impact factors that are tailored for bounding prediction norm. In order to cover heteroscedastic non-Gaussian noise, we rely on moderate deviation theory for self-normalized sums to achieve Gaussian-like results under weak conditions. Moreover, we derive bounds on the performance of ordinary least square (ols) applied to the model selected by $\sqrt{\mathrm {Lasso}}$ accounting for possible misspecification of the selected model. Under mild conditions, the rate of convergence of ols post $\sqrt{\mathrm {Lasso}}$ is as good as $\sqrt{\mathrm {Lasso}}$'s rate. As an application, we consider the use of $\sqrt{\mathrm {Lasso}}$ and ols post $\sqrt{\mathrm {Lasso}}$ as estimators of nuisance parameters in a generic semiparametric problem (nonlinear moment condition or $Z$-problem), resulting in a construction of $\sqrt{n}$-consistent and asymptotically normal estimators of the main parameters.
description: Published in at http://dx.doi.org/10.1214/14-AOS1204 the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org)