cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
3H-PYRAZOLO[4,3-F]QUINOLINE MOIETY AS A NOVEL PRIVILEGED KINASE INHIBITOR
Creators: name: Hernandez, Delmis E
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Medicinal and biomolecular chemistry not elsewhere classified
Oncology and carcinogenesis not elsewhere classified

description: Using a version of the Povarov-Doebner reaction, we were able to identify and develop a novel kinase inhibitor scaffold that is tunable, selective, and able to target drug-resistant mutant kinases. The 3H-pyrazolo[4,3-f]quinoline moiety was shown to be a privileged kinase inhibitor scaffold with a strong inhibition several different kinases. Herein, various 3H-pyrazolo[4,3-f]quinoline-containing compounds were synthesized quickly via the Povarov-Doebner multicomponent reaction. Our scaffold has demonstrated to potently inhibit FLT3 and CDK2 with nanomolar IC50 values. These FLT3 inhibitors were also shown to inhibit leukemic cell growth in a mouse disseminated AML model, establishing these 3H-pyrazolo[4,3-f]quinoline-containing compounds as lead compounds to develop into anti-cancer agents. The 3H-pyrazolo[4,3-f]quinoline moiety has potently inhibited ROCK1/2 with single digit nanomolar IC50 values, newly synthesized analogs with replacement of the boronic acid moiety with an amide also displayed inhibition of ROCK1/2. The most active compound (HSH3107) potently inhibits ROCK1/2 and although it did not display any antiproliferative effects against MDA-MB-231 (triple negative breast cancer cell line) at 1 µM, it did slow cell migration for up to 48 hours compared to DMSO control and Fasudil. Acyclic amide analogs of this scaffold have also led to the discovery of CDK12 and CDK13 inhibitors which can serve as a potential therapeutic in cancers where there may be no treatment strategy available or where resistance has emerged.
Additional file 2 of Genomic evaluation for two-way crossbred performance in cattle
Creators: name: Mei, Quanshun
name: Liu, Huiming
name: Zhao, Shuhong
name: Xiang, Tao
name: Christensen, Ole F
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Additional file 2: Table S1. Bias ( $$\widehat{\Delta }$$ Δ ^ ), dispersion ( $$\widehat{\mathrm{b}}$$ b ^ ), population accuracy ( $$\widehat{\mathrm{acc}}$$ acc ^ ), ratio of population accuracies ( $$\widehat{\uprho }$$ ρ ^ ) of EBV, average inbreeding coefficient (F) and average relationship (2f) for focal individuals (cut off date, May 1, 2021) and the estimated additive genetic variance in partial dataset( $${\upsigma }_{\mathrm{u},\infty }^{2}$$ σ u , ∞ 2 ) and whole dataset( $${\upsigma }_{\mathrm{u}}^{2}$$ σ u 2 ) with different method.
Analyzing the Relationship Between Social Media Usage and Suicide Rates Using Python
Creators: name: KUMAR, GANDHI VASANTH
Publisher: name: Zenodo
Year: 2024
Subjects: analytics
r
python
suiciderate
addiction
facebookuser
twitteruser

description: "Analyzing the Relationship Between Social Media Usage and Suicide Rates Using Python"This project aims to analyze the relationship between social media usage (Twitter and Facebook user counts) and suicide rates using statistical and machine learning techniques. The analysis explores correlations and builds a regression model to understand how changes in Twitter and Facebook user counts influence suicide rates.

Objectives:

Correlation Analysis:To determine the strength and nature of the relationship between the number of Twitter and Facebook users and suicide rates. Both Pearson and Spearman correlation methods are applied to assess linear and monotonic relationships, respectively.

Regression Analysis:To build a multiple regression model that evaluates the combined and individual effects of Twitter and Facebook user counts on suicide rates. The regression results provide insight into which platform has a stronger impact.

Comparative Analysis:To identify whether Twitter or Facebook has a stronger relationship with suicide rates by comparing regression coefficients.
Creative Protection: Capitalism and Governmental Authority in U.S. Tariff Politics, 1789-1860
Creators: name: Harris, Keith
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Historical studies not elsewhere classified
Economic history

description: Between the ratification of the Constitution and the outbreak of the Civil War, the American Congress regularly engaged in the delicate process of crafting trade legislation that balanced the revenue needs of the federal government with demands for protection of domestic industries. Both in the halls of Congress and throughout newspapers, pamphlets, and the private correspondence of economic actors, discussions of trade and tariffs stimulated political conflict and influenced what goods Americans possessed, produced, and consumed. This project explores how and why residents and representatives of the trans-Appalachian West engaged in the highly contentious tariff politics of the early American republic. I argue that trade policy elicited sustained controversy because of conflicting understandings of markets and the market process forged in response to the economic transformations of the nineteenth century. Throughout this period of market integration and commercial and industrial diversification, free trade advocates and protectionists developed and promoted competing assessments of what happened when supposedly “self-regulating” markets supplanted the authority of governmental institutions in guiding economic development. Merchants, farmers, and manufacturers in Kentucky, Ohio, Indiana, and Tennessee engaged in the politics of trade policy in a manner that reflected their distinct economic geography. In contrast to the more rigid embrace of protectionism among northern industrialists and free trade from those invested in southern cotton slavery, westerners fluctuated in their views on trade legislation. Because the success or failure of tariff laws consistently hinged on a small number of votes, the mixed support for free trade and protection from representatives of the western interest in Congress played a determinative role in shaping trade policy. Ultimately, western views on trade and tariffs illuminate a hybrid set of ideas that joined an economically liberal view of markets with demands for the exercise of legitimate governance in supporting regional development. The disruptive, yet innovative, growth of the first half of the nineteenth century encouraged Americans to look both to markets and nations for freedom from poverty and shelter from the process of “creative destruction.” These ideas emerged again in response to the monopolistic capitalism of the so-called “Gilded Age,” but they are rooted in debates over the power granted to Congress in trade policy that unfolded during the earliest years of nationhood.
Argo data management report 2015. Coriolis DAC & GDAC
Creators: name: Carval, Thierry
name: Coatanoan, Christine
Publisher: name: Ifremer
Year: 2015
Subjects: argo

description: This report covers the activity of Coriolis data centre for a one year period from October 1st 2014 to September 30th 2015.
sj-pdf-1-ijq-10.1177_16094069211047059 – Supplemental Material for Exploring Barriers and Facilitators to the Implementation of Pet Robots for People With Dementia in Nursing Homes: A Qualitative Research Protocol
Creators: name: Koh, Wei Qi
name: Toomey, Elaine
name: Casey, Dympna
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111099 Nursing not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental Material, sj-pdf-1-ijq-10.1177_16094069211047059 for Exploring Barriers and Facilitators to the Implementation of Pet Robots for People With Dementia in Nursing Homes: A Qualitative Research Protocol by Wei Qi Koh, Elaine Toomey and Dympna Casey in International Journal of Qualitative Methods
Additional file 1 of Spatial Distribution and Characteristics of Protein Content and Composition in Japonica Rice Grains: Implications for Sake Quality
Creators: name: Takahashi, Kei
name: Kohno, Hiromi
name: Okuda, Masaki
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Hematology
subject: Plant Biology
subject: Computational Biology

description: Supplementary Material 1
DEVELOPING MULTIPRONGED MODELS TO ENHANCE EFFECTIVENESS OF THE MANAGEMENT SYSTEM OF QUALITY CONTROL LABORATORIES. ADDITIONAL FOCUS ON SYNTHESIS AND CHARACTERIZATION FOR 5 NEW SALTS OF BEDAQUILINE
Creators: name: Okezue, Mercy A
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Pharmaceutical sciences
Other health sciences not elsewhere classified

description: A multidisciplinary study that evaluated Quality Control (QC) laboratory (lab) accreditation, and a salt screen for bedaquiline. Medicines testing facilities always seek to ensure the accuracy of data from their QC labs by attaining accreditation. This research proposed that an understanding of the cross-linkages in the requirements for implementing the 2 most widely used lab standards will facilitate testing efficiencies, and reduce the risks of accreditation failures. For the salt project, the study proposed that new salts of bedaquiline will be formed from acid-base reactions following the pKa rule. Characterizing the salts will provide specifications for the new molecular entities, and form a selection-criteria for a lead candidate. The research reviewed 2 lab standards: the ISO/IEC17025:2017 and the WHO Good Practices for Pharmaceutical QC labs, and identified the areas of overlap in their requirements. It then developed and tested affordable models that mitigate the 3 identified areas of high risks to lab accreditation. Additionally, it mixed equimolar amounts of bedaquiline base with select counterions that have ≥ 2 pKa units in organic solvents, to yield salts. ICHQ6 guidance was used to characterize the new salts. The highest risks to laboratory accreditation were linked to 3 quality system metrics, namely: ‘Proficiency Testing’, ‘Validation’, and ‘Measurement Traceability’. Using the identified areas of overlap in the 2 laboratory standards, this research provided tutorial videos, a competency matrix, and some instrument validation data, to optimize the requirements for lab accreditation. For the salt screen, five new candidates were synthesized as alternatives to the existing fumarate salt of bedaquiline. The results of their physicochemical properties were used for selecting a lead moiety. The research provided evidence that the multipronged models developed will improve efficiencies in QC labs, and increase their chances of attaining international accreditations. It also discovered the best modes for synthesizing the new salts of bedaquiline, and provided critical data to help Pharma make an informed choice for a lead candidate.
sj-docx-2-mdm-10.1177_0272989X211043077 – Supplemental material for Defensive Medicine Practices: Scale Development and Validation
Creators: name: Ünal, Özgün
name: Akbolat, Mahmut
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, sj-docx-2-mdm-10.1177_0272989X211043077 for Defensive Medicine Practices: Scale Development and Validation by Özgün Ünal and Mahmut Akbolat in Medical Decision Making
sj-pdf-1-eso-10.1177_23969873211042192 – Supplemental Material for European Stroke Organisation and European Academy of Neurology joint guidelines on post-stroke cognitive impairment
Creators: name: Quinn, Terence J
name: Richard, Edo
name: Teuschl, Yvonne
name: Gattringer, Thomas
name: Hafdi, Melanie
name: O’Brien, John T
name: Merriman, Niamh
name: Gillebert, Celine
name: Huyglier, Hanne
name: Verdelho, Ana
name: Schmidt, Reinhold
name: Ghaziani, Emma
name: Forchammer, Hysse
name: Pendlebury, Sarah T
name: Bruffaerts, Rose
name: Mijajlovic, Milija
name: Drozdowska, Bogna A
name: Ball, Emily
name: Markus, Hugh S
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Cardiology
subject: Medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine

description: Supplemental Material, sj-pdf-1-eso-10.1177_23969873211042192 for European Stroke Organisation and European Academy of Neurology joint guidelines on post-stroke cognitive impairment by Terence J Quinn, Edo Richard, Yvonne Teuschl, Thomas Gattringer, Melanie Hafdi, John T O’Brien, Niamh Merriman, Celine Gillebert, Hanne Huyglier, Ana Verdelho, Reinhold Schmidt, Emma Ghaziani, Hysse Forchammer, Sarah T Pendlebury, Rose Bruffaerts, Milija Mijajlovic, Bogna A Drozdowska, Emily Ball and Hugh S Markus in European Stroke Journal
sj-docx-2-smo-10.1177_20503121211050510 – Supplemental material for Towards development of guidelines for virtual administration of paediatricstandardized language and literacy assessments: Considerations for clinicians and researchers
Creators: name: Wood, Emily
name: Bhalloo, Insiya
name: McCaig, Brittany
name: Feraru, Cristina
name: Molnar, Monika
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: Cardiology
subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine
subject: 110305 Emergency Medicine
subject: 110306 Endocrinology
subject: 110308 Geriatrics and Gerontology
subject: 110904 Neurology and Neuromuscular Diseases
subject: 111099 Nursing not elsewhere classified
subject: 111199 Nutrition and Dietetics not elsewhere classified
subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: 110314 Orthopaedics
subject: 110604 Sports Medicine
subject: 110315 Otorhinolaryngology
subject: 111702 Aged Health Care
subject: 111403 Paediatrics
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 110203 Respiratory Diseases
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology
subject: 110323 Surgery
subject: 70706 Veterinary Medicine
subject: FOS: Veterinary sciences

description: Supplemental material, sj-docx-2-smo-10.1177_20503121211050510 for Towards development of guidelines for virtual administration of paediatricstandardized language and literacy assessments: Considerations for clinicians and researchers by Emily Wood, Insiya Bhalloo, Brittany McCaig, Cristina Feraru and Monika Molnar in SAGE Open Medicine
Catalytic Vinylidene Transfer and Insertion Reactions
Creators: name: Kalb, Annah E
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Catalysis and mechanisms of reactions
Computational chemistry
Organic chemistry not elsewhere classified
Organometallic chemistry

description: Metal-stabilized carbenes, most commonly formed through the decomposition of diazoacetates, are extensively employed in organic synthesis. However, several classes of carbenes, such as vinylidenes, are challenging to utilize in transition metal catalysis due to the instability of the required diazo precursors. To overcome this challenge, most transition metal-catalyzed vinylidene transfer and insertion methods rely on alkynes as vinylidene precursors. Only catalysts that form stable M=C multiple bonds and weak M(π-C≡C) interactions can promote this alkyne isomerization, and the resultant metal(vinylidene) species is often less reactive compared to free vinylidenes. The discovery of 1,1-dihaloalkenes as precursors to transition metal vinylidene complexes has significantly expanded the scope of vinylidene transfer and insertion reactions. Dinuclear catalysts were found to promote the reductive cyclization of 1,1-dichloroalkenes containing pendant alkenes to form methylenecycloalkenes, and mechanistic studies are consistent with the formation of a Ni2(vinylidene) species. Furthermore, these catalysts promote reductive three-component cycloaddition reactions with 1,1-dichloroalkenes and aldehydes to generate methylenedioxolanes, which upon treatment with aqueous acid provides access in one step to new, unsymmetrical aliphathic α-hydroxy ketones that would be difficult to access with existing methods. Under dilute conditions, an enone byproduct is formed and a DFT model is presented that accounts for concentration-based reaction selectivity.
sj-docx-1-jad-10.1177_10870547211050946 – Supplemental material for “My mom calls it Annaland”: A Qualitative Study of Phenomenology, Daily Life Impacts, and Treatment Considerations of Sluggish Cognitive Tempo
Creators: name: Becker, Stephen P.
name: Fredrick, Joseph W.
name: Foster, Josalyn A.
name: Yeaman, Kiley M.
name: Epstein, Jeffery N.
name: Froehlich, Tanya E.
name: Mitchell, John T.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: Education
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, sj-docx-1-jad-10.1177_10870547211050946 for “My mom calls it Annaland”: A Qualitative Study of Phenomenology, Daily Life Impacts, and Treatment Considerations of Sluggish Cognitive Tempo by Stephen P. Becker, Joseph W. Fredrick, Josalyn A. Foster, Kiley M. Yeaman, Jeffery N. Epstein, Tanya E. Froehlich and John T. Mitchell in Journal of Attention Disorders
sj-docx-1-aut-10.1177_13623613211049011 – Supplemental material for Early diagnosis of autism in the community is associated with marked improvement in social symptoms within 1–2 years
Creators: name: Gabbay-Dizdar, Nitzan
name: Ilan, Michal
name: Meiri, Gal
name: Faroy, Michal
name: Michaelovski, Analya
name: Flusser, Hagit
name: Menashe, Idan
name: Koller, Judah
name: Zachor, Ditza A
name: Dinstein, Ilan
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: Education
subject: 130312 Special Education and Disability
subject: FOS: Educational sciences

description: Supplemental material, sj-docx-1-aut-10.1177_13623613211049011 for Early diagnosis of autism in the community is associated with marked improvement in social symptoms within 1–2 years by Nitzan Gabbay-Dizdar, Michal Ilan, Gal Meiri, Michal Faroy, Analya Michaelovski, Hagit Flusser, Idan Menashe, Judah Koller, Ditza A Zachor and Ilan Dinstein in Autism
Additional file 2 of Identification of FCN1 as a novel macrophage infiltration-associated biomarker for diagnosis of pediatric inflammatory bowel diseases
Creators: name: Chen, Xixi
name: Gao, Yuanqi
name: Xie, Jinfang
name: Hua, Huiying
name: Pan, Chun
name: Huang, Jiebin
name: Jing, Mengxia
name: Chen, Xuehua
name: Xu, Chundi
name: Gao, Yujing
name: Li, Pu
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 2: Figure S1. Immune infiltration landscape in PIBD mucosa with CIBERSORT. Figure S2. Positive correlation between FCN1 expression and M0/M1 macrophage infiltration in the GSE126124 dataset. Figure S3. Cell type analysis of single-cell RNA-seq data (GSE121380). Figure S4. Upregulated expression of FCN1 and IL1B in mucosal macrophages from PIBD subjects of the single-cell RNA-seq dataset (GSE121380). Figure S5. The GSEA enrichment plots of significantly enriched pathways in FCN1high macrophages compared to FCN1low macrophages in Fig. 4C. Figure S6. Effect of human recombinant FCN1 protein (rhFCN1) on the NLRP3/IL-1β axis was investigated in THP-1-derived macrophages.
sj-pdf-1-aor-10.1177_00034894211050627 – Supplemental material for “A Major Quality of Life Issue”: A Survey-Based Analysis of the Experiences of Adults With Laryngotracheal Stenosis with Mucus and Cough
Creators: name: Clunie, Gemma M.
name: Anderson, Catherine
name: Savage, Matthew
name: Hughes, Catherine
name: Roe, Justin W. G.
name: Sandhu, Gurpreet
name: McGregor, Alison
name: Alexander, Caroline M.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110315 Otorhinolaryngology
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-1-aor-10.1177_00034894211050627 for “A Major Quality of Life Issue”: A Survey-Based Analysis of the Experiences of Adults With Laryngotracheal Stenosis with Mucus and Cough by Gemma M. Clunie, Catherine Anderson, Matthew Savage, Catherine Hughes, Justin W. G. Roe, Gurpreet Sandhu, Alison McGregor and Caroline M. Alexander in Annals of Otology, Rhinology & Laryngology
sj-pdf-1-asp-10.1177_00037028211047898 - Supplemental material for Calculation of Spectral Optical Constants Using Combined Ellipsometric and Reflectance Methods for Smooth and Rough Bulk Samples
Creators: name: Fortin, Gilles
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies

description: Supplemental material, sj-pdf-1-asp-10.1177_00037028211047898 for Calculation of Spectral Optical Constants Using Combined Ellipsometric and Reflectance Methods for Smooth and Rough Bulk Samples by Gilles Fortin in Applied Spectroscopy
HAVE YOU HEARD OF CELL-CULTURED MEAT? ATTITUDE CERTAINTY’S EFFECTS ON CONSUMER INFORMATION SHARING ABOUT INNOVATION
Creators: name: Dolick, Kirstin N
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Communication studies

description: Among the factors influencing consumer innovation acceptance in the context of health, interpersonal communication is highly understudied. This project focuses on one dimension of interpersonal communication by exploring how attitudinal differences between communicators influence information sharing. Two studies are reported using a diffusion chain framework to explore the effects of attitude strength on the amount and type of information shared about an innovation. Study 1 identified a tendency for those with greater certainty to share more than those without certain attitudes. There was also a tendency for those with unfavorable attitudes and those with extreme attitudes to share a greater proportion of attitudinally consistent information. These findings were not found to be significant. Study 2 failed to support the hypotheses that the first chain member’s attitude or message influences the amount or type of information shared by the second chain member. Results suggest that the relationship between attitudes and information sharing may be more complex than suggested by previous research.
Additional file 4 of Identification of FCN1 as a novel macrophage infiltration-associated biomarker for diagnosis of pediatric inflammatory bowel diseases
Creators: name: Chen, Xixi
name: Gao, Yuanqi
name: Xie, Jinfang
name: Hua, Huiying
name: Pan, Chun
name: Huang, Jiebin
name: Jing, Mengxia
name: Chen, Xuehua
name: Xu, Chundi
name: Gao, Yujing
name: Li, Pu
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 4: Table S3. qRT-PCR primer sequences.
sj-pdf-1-jdr-10.1177_00220345211042795 – Supplemental material for Enamel Caries Detection and Diagnosis: An Analysis of Systematic Reviews
Creators: name: Walsh, T.
name: Macey, R.
name: Ricketts, D.
name: Carrasco Labra, A.
name: Worthington, H.
name: Sutton, A.J.
name: Freeman, S.
name: Glenny, A.M.
name: Riley, P.
name: Clarkson, J.
name: Cerullo, E.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine
subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, sj-pdf-1-jdr-10.1177_00220345211042795 for Enamel Caries Detection and Diagnosis: An Analysis of Systematic Reviews by T. Walsh, R. Macey, D. Ricketts, A. Carrasco Labra, H. Worthington, A.J. Sutton, S. Freeman, A.M. Glenny, P. Riley, J. Clarkson and E. Cerullo in Journal of Dental Research
Regular Random Field Solutions for Stochastic Evolution Equations
Creators: name: Antoni, Markus
Publisher: name: Karlsruhe
Year: 2017
Subjects: Stochastic integration
stochastic convolution
maximal regularity
stochastic evolution equations
pathwise Hölder regularity

description: In this thesis we investigate stochastic evolution equations for random fields X: Omega x [0; T] x U -> R, where [0; T] is a time interval, (Omega; F; P) a measure space representing the randomness of the system, and U is typically a domain in Rd (or again a measure space). More precisely, we concentrate on the parabolic situation where A is the generator of an analytic semigroup on Lp(U). We look for mild solutions so that X has values in Lp(U;Lq[0; T]) almost surely under appropriate Lipschitz and linear growth conditions on the nonlinearities. Compared to the classical semigroup approach, which gives X \in Lq([0; T];Lp(U)) almost surely, the order of integration is reversed. We show that this new approach together with a strong Doob and Burkholder-Davis-Gundy inequality leads to strong regularity results in particular for the time variable of the random field X, e.g. pointwise Hölder estimates for the paths, P-almost surely. For less-optimal regularity estimates we only need the relatively mild assumption that the resolvents of A extend uniformly to Lp(U;Lq[0; T]). However, in the maximal regularity case the difficulty of the reversed order of integration in time and space makes extended functional calculi results necessary. As a consequence, we obtain suitable estimates for deterministic and stochastic convolutions. Using Sobolev embedding theorems, we obtain solutions in Lr(Omega;Lp(U;C\alpha[0; T])). In several applications where A is an elliptic operator on a domain in Rd we show that for concrete examples of stochastic partial differential equations our theory leads to stronger results as known in the literature.
title: Exploiting Smart TVs using the HbbTV Protocol
Creators: name: Danis, Andrej
Publisher: name: TU Wien
Year: 2025
Subjects: subject: Smart TV
subject: Hybrid Broadcast Broadband TV
subject: Web Security
subject: Web Privacy
subject: Smart TV
subject: Hybrid Broadcast Broadband TV
subject: Web Security
subject: Web Privacy

description: Hybrid Broadcast Broadband TV (HbbTV) is a protocol developed to combine standard television broadcasts with digital content over the Internet. With millions of supported devices around Europe, questions about the protocol's security arise. In this thesis, we analyze the security of HbbTV applications by doing practical experimental research on selected smart TVs. We first introduce the required background about smart TVs and HbbTV to the reader so that the reader can understand the problem. Afterward, we show the current state of the art on HbbTV and TV security. Further, we introduce the selected evaluation targets and analyze their software. Following that, we explain and demonstrate how to develop and deploy an HbbTV application. Subsequently, we use the knowledge from our analyses of the smart TVs and the HbbTV protocol to exploit smart TVs using HbbTV by following our proposed threat model. Based on that, we analyze the outcomes of the exploits for each of our evaluation targets. Furthermore, we discuss the results of our experiments and the limitations and propose further research topics to improve HbbTV security. We created an HbbTV-specific threat model, based on which we prepared possible attack scenarios to test. We tested the attacks on our selected targets of evaluation of different vendors and proved the feasibility of such attacks. Furthermore, we proved it is possible to scan the local network and send HTTP requests to other devices on the local network, broadening the attack surface.
Additional file 1 of Functional analysis and validation of oncodrive gene AP3S1 in ovarian cancer through filtering of mutation data from whole-exome sequencing
Creators: name: Kong, Deshui
name: Wu, Yu
name: Liu, Qiyu
name: Huang, Cuiyu
name: Wang, Tongxia
name: Huang, Zongyao
name: Gao, Yan
name: Li, Yuan
name: Guo, Hongyan
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer

description: Additional file 1. Mutation word cloud and information on HRD-related genes.
An Intelligent UAV Platform For Multi-Agent Systems
Creators: name: Kapoor, Taashi
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Aerospace engineering not elsewhere classified
Autonomous vehicle systems
Computer vision
Knowledge representation and reasoning
Cognitive neuroscience
Artificial intelligence not elsewhere classified

description: This thesis presents work and simulations containing the use of Artificial Intelligence for real-time perception and real-time anomaly detection using the computer and sensors onboard an Unmanned Aerial Vehicle. One goal of this research is to develop a highly accurate, high-performance computer vision system that can then be used as a framework for object detection, obstacle avoidance, motion estimation, 3D reconstruction, and vision-based GPS denied path planning. The method developed and presented in this paper integrates software and hardware techniques to reach optimal performance for real-time operations. This thesis also presents a solution to real-time anomaly detection using neural networks to further the safety and reliability of operations for the UAV. Real-time telemetry data from different sensors are used to predict failures before they occur. Both these systems together form the framework behind the Intelligent UAV platform, which can be rapidly adopted for different varieties of use cases because of its modular nature and on-board suite of sensors.
Brève introduction à la fouille de grandes bases de données océaniques
Creators: name: Maze, Guillaume
name: Mercier, Herle
name: Fablet, Ronan
name: Lenca, Philippe
name: Piolle, Jean-Francois
Publisher: name: Ifremer
Year: 2014

description: Les bases de données marines, alimentées par les satellites et les robots autonomes sous-marins comme les flotteurs du réseau Argo, sont de plus en plus grandes (plusieurs dizaines de gigaoctets et teraoctets) et rapidement évolutives (elles changent d’heure en heure). Cette augmentation spectaculaire de la dimension et de la complexité des données rend difficile leur exploitation avec les outils standards. Or, c’est à partir de l’analyse des données que les chercheurs pourront réaliser de nouvelles découvertes scientifiques sur la dynamique des océans, à grande et petite échelles, et les changements climatiques régionaux et globaux.

L'école d’été OBIDAM14 visait à contribuer à lever ces verrous d’analyse en introduisant les méthodes de fouille de données aux scientifiques de la communauté de recherche en océanographie physique. Pour un des premiers évènements académiques sur ce thème en France, OBIDAM14 a permis de donner un aperçu de ces méthodes. Le comité scientifique de l'école présente ici un compte-rendu des interventions.
sj-docx-7-pie-10.1177_09544089211046081 - Supplemental material for Modeling of cattaneo-christov heat and mass flux on non-newtonian hydromagnetic fluid with variable thermal and solutal properties
Creators: name: Babu, B. Hari
name: Srinivasa Rao, P.
name: Reddy, M. Gnaneswara
name: Varma, S.V.K.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies
subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, sj-docx-7-pie-10.1177_09544089211046081 for Modeling of cattaneo-christov heat and mass flux on non-newtonian hydromagnetic fluid with variable thermal and solutal properties by B. Hari Babu, P. Srinivasa Rao, M. Gnaneswara Reddy and S.V.K. Varma in Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering
The Role of Systemic Dehydration in Vocal Fold Healing
Creators: name: Venkatraman, Anumitha
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Animal physiology - biophysics
Animal physiology - cell
Animal physiology - systems
Other biological sciences not elsewhere classified
Gene expression (incl. microarray and other genome-wide approaches)

description: Systemic dehydration negatively alters epithelial cell junction markers and inflammatory mediators in vocal fold tissue. In other organs, dehydration canhave the following suboptimal outcomes; prolonged inflammation and delayed re-epithelization.It is surprising that the adverse role of systemic dehydration in vocal fold healing has not been directly demonstrated when dehydration has the potential to alter recovery following injury. The similarities between healing in dermal and mucosal tissue indicate an increased need to understand the effects of dehydration onvocal fold recovery. Suboptimal vocal fold healing can have downstream consequences on vibratory function. Before functional voice changes can be delineated, there is a need to characterize the cellular interactions of systemic dehydration and vocal fold healing. The overarching research aim of this dissertation is to investigate the interaction of systemic dehydration and vocal fold healing on the gene expression of inflammatory and epithelial cell junction markers, following acute vocal fold injury.Gene expressionoutcomes werecompared in four groups;systemically-dehydrated,and euhydrated rats with minor, bilateral vocal fold injuriesand systemically-dehydrated and euhydrated rats without vocal fold injuries (N=9/group). We hypothesized that systemic dehydration(compared to euhydration)would cause an upregulation of pro and anti-inflammatory mediators with injury, but adownregulation of these inflammatory markers in the absence of injury. We also hypothesized that systemic dehydration(compared to euhydration)would cause a downregulation of epithelial cell junction markers with and without injury, butthat the effects of dehydration would be exacerbated with injury. We found that the gene expression of pro-inflammatory cytokines was differentially expressed in systemically-dehydrated injured vocal old tissue when compared to systemically-euhydrated injured vocal fold tissue, 24 hours after vocal fold injury. These data lay the groundwork for future studies characterizing the later stages of interaction of systemic dehydration and injury.
sj-pdf-1-ajs-10.1177_03635465211044142 – Supplemental material for Higher Rate of Return to Preinjury Activity Levels After Anterior Cruciate Ligament Reconstruction With a Bone–Patellar Tendon–Bone Versus Hamstring Tendon Autograft in High-Activity Patients: Results From the New Zealand ACL Registry
Creators: name: Rahardja, Richard
name: Love, Hamish
name: Clatworthy, Mark G.
name: Monk, Andrew Paul
name: Young, Simon W.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences
subject: 110323 Surgery

description: Supplemental material, sj-pdf-1-ajs-10.1177_03635465211044142 for Higher Rate of Return to Preinjury Activity Levels After Anterior Cruciate Ligament Reconstruction With a Bone–Patellar Tendon–Bone Versus Hamstring Tendon Autograft in High-Activity Patients: Results From the New Zealand ACL Registry by Richard Rahardja, Hamish Love, Mark G. Clatworthy, Andrew Paul Monk and Simon W. Young in The American Journal of Sports Medicine
Additional file 1 of Systematic evaluation of membrane-camouflaged nanoparticles in neutralizing Clostridium perfringens ε-toxin
Creators: name: Xu, Jinglin
name: Li, Dongxue
name: Kang, Lin
name: Liu, Tingting
name: Huang, Jing
name: Li, Jiaxin
name: Lv, Jing
name: Wang, Jing
name: Gao, Shan
name: Li, Yanwei
name: Yuan, Bing
name: Zhao, Baohua
name: Wang, Jinglin
name: Xin, Wenwen
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Systematic evaluation of membrane-camouflaged nanoparticles in neutralizing Clostridium perfringens ε-toxin. Figure S1. In vitro toxicities of recombinant ETX. ETX with different tags (GST and 6×His) did not significantly differ in toxicities (n = 3). Data are presented as the means ± SD. Figure S2. MDCK cells were exposed to 2 mg nanoparticles and 20 nM of GST-ETX for 1h at 37°C. The cells were observed by confocal microscopy. (Scale bar: 1 mm). Figure S3. Four groups of eight-week-old female BALB/c mice, were injected with increasing dosages of GST-ETX in intravenous respectively. The survival curves of the mice in the next 7 days (n = 6). Figure S4. Representative sections made from various organs of experimental mice with intravenous injection, stained with H&E (scale bar: 2 mm). Figure S5. In vitro fluorescence images of DiR in organs of mice which injected intravenously with Cy5.5-ETX and PBS. Figure S6. In vitro fluorescence images of DiR in organs of mice which injected intravenously with Cy5.5-ETX and DiR-RNPs. Figure S8. In vitro fluorescence images of Cy5.5 in organs of mice which injected intravenously with Cy5.5-ETX and PBS. Figure S9. In vitro fluorescence images of Cy5.5 in organs of mice which injected intravenously with Cy5.5-ETX and DiR-RNPs. Figure S9. Real-time in vivo fluorescence images of mice after lung delivery or intravenous injection 10 min. (A) Lung delivery DiR-RNPs, DiR-RNPs were evenly dispersed in lung of the mouse but did not escape the lung. Radiant efficiency exceeded 2×109 in the lung. (B) Lung delivery PBS. (C) Intravenous injection PBS. (D) Intravenous injection DiR-RNPs, DiR-RNPs spread throughout the mouse by the bloodstream. The systemic radiation efficiency of mouse was generally low, and the maximum radiation efficiency did not reach 2×109. Figure S10. Four groups of eight-week-old female BALB/c mice, were introduced by aerosol into the lungs with increasing dosages of GST-ETX. The survival curves of the mice in the next 14 days (n = 6). Figure S11. Representative sections made from various organs of experimental mice with lung delivery, stained with H&E (scale bar: 2 mm).
sj-docx-2-tpp-10.1177_20451253211045870 – Supplemental material for Efficacy and safety of lamotrigine in the treatment of bipolar disorder across the lifespan: a systematic review
Creators: name: Besag, Frank M.C.
name: Vasey, Michael J.
name: Sharma, Aditya N.
name: Lam, Ivan C.H.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: FOS: Clinical medicine

description: Supplemental material, sj-docx-2-tpp-10.1177_20451253211045870 for Efficacy and safety of lamotrigine in the treatment of bipolar disorder across the lifespan: a systematic review by Frank M.C. Besag, Michael J. Vasey, Aditya N. Sharma and Ivan C.H. Lam in Therapeutic Advances in Psychopharmacology
sj-docx-5-hpp-10.1177_15248399211046578 – Supplemental material for Collaborating With Student Parents as Participatory Researchers in a Qualitative Study
Creators: name: Rauh, Lauren
name: Manze, Meredith G.
name: Watnick, Dana
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: Sociology
subject: FOS: Sociology

description: Supplemental material, sj-docx-5-hpp-10.1177_15248399211046578 for Collaborating With Student Parents as Participatory Researchers in a Qualitative Study by Lauren Rauh, Meredith G. Manze and Dana Watnick in Health Promotion Practice
sj-docx-1-smo-10.1177_20503121211051573 – Supplemental material for Predictors of hospital mortality among patients with COVID-19 in Tehran, Iran
Creators: name: Esfahanian, Fatemeh
name: SeyedAlinaghi, SeyedAhmad
name: Janfaza, Nazanin
name: Tantuoyir, Marcarious M.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: Cardiology
subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine
subject: 110305 Emergency Medicine
subject: 110306 Endocrinology
subject: 110308 Geriatrics and Gerontology
subject: 110904 Neurology and Neuromuscular Diseases
subject: 111099 Nursing not elsewhere classified
subject: 111199 Nutrition and Dietetics not elsewhere classified
subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: 110314 Orthopaedics
subject: 110604 Sports Medicine
subject: 110315 Otorhinolaryngology
subject: 111702 Aged Health Care
subject: 111403 Paediatrics
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 110203 Respiratory Diseases
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology
subject: 110323 Surgery
subject: 70706 Veterinary Medicine
subject: FOS: Veterinary sciences

description: Supplemental material, sj-docx-1-smo-10.1177_20503121211051573 for Predictors of hospital mortality among patients with COVID-19 in Tehran, Iran by Fatemeh Esfahanian, SeyedAhmad SeyedAlinaghi, Nazanin Janfaza and Marcarious M. Tantuoyir in SAGE Open Medicine
sj-pdf-1-cep-10.1177_03331024211046618 - Supplemental material for Clinical correlates of hypothalamic functional changes in migraine patients
Creators: name: Messina, Roberta
name: Rocca, Maria A
name: Valsasina, Paola
name: Misci, Paolo
name: Filippi, Massimo
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: Neuroscience

description: Supplemental material, sj-pdf-1-cep-10.1177_03331024211046618 for Clinical correlates of hypothalamic functional changes in migraine patients by Roberta Messina, Maria A Rocca, Paola Valsasina, Paolo Misci and Massimo Filippi in Cephalalgia
DECIPHERING THE GUT-LIVER CONNECTION: UNDERSTANDING MECHANISMS OF LIVER DISEASE
Creators: name: Dr. Olivia, Anderson
Publisher: name: continental journal
Year: 2024
Subjects: gut flora, gut-liver axis, intestinal permeability, bacterial translocation, liver diseases

description: The human gastrointestinal tract houses a complex ecosystem of microorganisms known as gut flora, crucial for maintaining symbiotic host-microbe relationships. Disruption of this balance can lead to intestinal permeability and bacterial translocation, contributing to various diseases. The liver's intimate connection with the gut is described by the "gut-liver axis." Dysregulation of gut microbiota can trigger immune responses, resulting in inflammatory reactions and various liver diseases. This paper explores the intricate relationship between gut microbiota and liver diseases, offering insights into diagnosis and treatment.
Additional file 1 of Optimization of landfill gas generation based on a modified first-order decay model: a case study in the province of Quebec, Canada
Creators: name: Malmir, Tahereh
name: Lagos, Daniel
name: Eicker, Ursula
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1: Table S1. Waste segregation and corresponding kCH4 values, biodegradation half-life in years-1 for OW in a landfill, based on IPCC recommended ranges [adapted from IPCC (IPCC 2019)]. Table S2. Number, name, and description of optimizing scenarios for CH4 modeling.
Auditory tracking and scene analysis - perceptual timescales and neural correlates
Creators: name: Singh, Ravinderjit
Publisher: name: Purdue University Graduate School
Year: 2022
Subjects: Biomedical engineering not elsewhere classified

description: Temporal processing and temporal coherence processing are fundamental components of auditory processing and the focus of this thesis. Cortical temporal processing in particular is understudied in humans. This dissertation makes three contributions that help characterize auditory temporal processing, and its relationship to auditory perception in humans. Experiment 1 develops a novel systems identification approach utilizing modified maximum length sequences (m-seq) to robustly measure cortical temporal processing noninvasively. Using this technique, it is found that cortex's ability to track dynamic spatial auditory cues can explain the ability to utilize dynamic binaural information to do a spatial unmasking task. This result combined with behavioral data that shows FM tracking extends out to similar rates as spatial tracking demonstrates how auditory tracking broadly is constrained by the temporal properties of cortex. Experiment 2 develops a novel measure of temporal processing, called the modulation temporal response function (mod-TRF), which can separate the underlying sources contributing to modulation processing along the auditory system from short, middle, and late latency regions. The mod-TRF has a robust SNR at the individual level giving it the potential to become an ubiquitous tool to assess temporal processing and auditory activity generally across individuals. The utility of the mod-TRF is demonstrated by evaluating how attention affects different sources along the auditory pathway. Other studies utilizing the mod-TRF could explore how temporal processing in early and late areas of the auditory system changes with aging, hearing loss, musicianship, and neuropsychiatric disorders. Experiment 3 establishes a novel physiological measure of across channel temporal coherence processing to measure auditory binding ability across individuals. It is demonstrated how this novel temporal coherence measure can explain performance on a behavioral temporal coherence detection task, speech-in-noise task, and comodulation masking release. Lastly, it is explored how social and communicative features in individuals, measured via the Autism Quotient, align with differences in auditory ability at various tasks.