cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Attention diversion improves response inhibition of immediate reward, but only when it is beneficial: An fMRI study
Creators: name: Scalzo, Franco
name: O’Connor, David A.
name: Orr, Catherine
name: Murphy, Kevin
name: Hester, Robert
Publisher: name: Swinburne
Year: 2024

description: Deficits of self-control are associated with a number of mental state disorders. The ability to direct attention away from an alluring stimulus appears to aid inhibition of an impulsive response. However, further functional imaging research is required to assess the impact of shifts in attention on self-regulating processes. We varied the level of attentional disengagement in an functional magnetic resonance imaging (fMRI)-based Go/No-go task to probe whether diversion of attention away from alluring stimuli facilitates response inhibition. We used the attention-grabbing characteristic of faces to exogenously direct attention away from stimuli and investigated the relative importance of attention and response inhibition mechanisms under different delayed reward scenarios [i.e., where forgoing an immediate reward ($1) led to a higher ($10) or no payoff in the future]. We found that diverting attention improved response inhibition performance, but only when resistance to an alluring stimulus led to delayed reward. Region of interest analyses indicated significant increased activity in posterior right inferior frontal gyrus during successful No-go trials for delayed reward trials compared to no delayed reward trials, and significant reduction in activity in the superior temporal gyri and left caudate in contexts of high attentional diversion. Our findings imply that strategies that increase the perceived benefits of response inhibition might assist individuals in abstaining from problematic impulsive behaviors.
Identification of a new antifungal oligoacetal derivative produced by Streptomyces toxytricini against Candida albicans
Creators: name: Azeiz, Ahmed Z. Abdel
name: Hanafi, Donia K.
name: Hasanein, Sameh E.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified

description: Thirty actinomycete isolates were isolated from soil and tested against Candida albicans in vitro. The active isolate was identified by 16s-rRNA gene sequencing method as Streptomyces toxytricini. The antifungal compound was extracted with ethyl acetate followed by diethyl ether. Both HPLC and GC–MS analysis confirmed presence of one pure compound in the diethyl ether extract. The compound is a yellow liquid has a maximum absorbance at 240 nm in methanol. The chemical structure was elucidated by 1D and 2D-NMR and IR analyses. The elucidated molecular formula was C36H54O14. The compound is a polyacetal tricyclononane derivative, composed of a tricyclononane ring attached from the carbon atom number four with an oligo-acetal chain (six acetal groups in chain) and from the carbon atom number seven with a methoxy carbonyl benzene-1,3-dicarboxylic acid. The purposed name is: 4- {[tricycle(3.2.1.11,3)non-8-yl] methoxy carbonyl benzene-1,3-dicarboxylic acid} (2,4,5,6,7,8,9 heptaoxa, 3-ethoxy, 5,6,7,9-tetramethyl unidecane).
Characterising fitness landscapes using predictive local search
Creators: name: Gheorghita, Marius
name: Moser, Irene
name: Aleti, Aldeida
Publisher: name: Swinburne
Year: 2024

description: Search space characterisation is a field that strives to define properties of gradients with the general aim of finding the most suitable stochastic algorithms to solve the problems. Diagnostic Optimisation characterises the search landscape while the search progresses. In this work, we have improved Predictive Diagnostic Optimisation to reduce the cost of the local search by introducing a sampling procedure to explore the neighbourhood. The neigbhourhood is created by the swap operator and the sample size recorded during the search is shown to correlate with the known characteristics of the problems.
Leioseius Berlese
Creators: name: JoharchiK, Omid
name: DökerK, Ismail
name: KhaustovK, Vladimir A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Mesostigmata
Ascidae
Leioseius

description: Genus Leioseius Berlese
 Lasioseius (Leioseius) Berlese, 1916: 45.
 Type species: Ameroseius minusculus Berlese, 1905, by original designation.
description: Published as part of JoharchiK, Omid, DökerK, Ismail & KhaustovK, Vladimir A., 2023, A new species and a new record of Leioseius Berlese (Acari: Mesostigmata: Ascidae) from Russia, with a review of the Russian species of the genus, pp. 1139-1153 in Acarologia 63 (4) on page 1140, DOI: 10.24349/fpby-by6k, http://zenodo.org/record/10785762
The Impact of Splitting a Long Online Questionnaire on Data Quality
Creators: name: Andreadis, Ioannis
name: Kartsounidou, Evangelia
Publisher: name: Survey Research Methods
Year: 2020

description: Long self-administered questionnaires may suffer from lower response rates, higher drop-outs, and lower quality responses. A shorter questionnaire reduces the burden of respondents. Using this as a starting point, we test the following method: split the long questionnaire into sub-questionnaires; invite everyone to answer the first sub-questionnaire; when respondents complete the first sub-questionnaire, invite them to answer the second sub-questionnaire, and so on. We present evidence that after splitting a long questionnaire into two shorter parts, the response rates of these sub-questionnaires are significantly higher than the response rate of the original, undivided, long questionnaire. However, the cumulative response rate of both parts is lower than the response rate of the long undivided questionnaire. Finally, we show that the respondents of the survey using the original, long questionnaire: i) provide more non-substantive answers (“neither/nor”) to the Likert-type scale items and ii) give shorter answers to the open-ended questions of the survey than the respondents of the split survey. On the other hand, there is no significant difference between the long and the split questionnaire on the other indicators of response quality we have tested: item-nonresponse, speeding and straight-lining. This paper presents some first insights on splitting a long questionnaire into shorter parts. For now, the results are not promising to suggest with confidence to split the long questionnaire for the purpose of obtaining high data quality. Further research is needed to find the optimal interval time between the sub-questionnaires or the optimal length of the sub-questionnaires in which the overall response rate is maximized.
description: Survey Research Methods, Vol 14 No 1 (2020)
Measuring geographic mobility: Comparison of estimates from longitudinal and cross-sectional data
Creators: name: Watson, Nicole
Publisher: name: Survey Research Methods
Year: 2020

description: Attrition of sample members from a longitudinal survey can undermine the quality of the data and its research potential, especially when the sample members who drop out are different from those who do not. People who move house are more likely to drop out of the survey as they are harder to locate, and once located, may be harder to interview in the remaining fieldwork time available. Moving coincides with many other life events (such as changes in marital status, the birth of a child, buying a home, changes in employment, or retirement) and if movers are not adequately interviewed, this may result in the study under-representing these changes and the events that occur after a move. This paper examines the weighted estimates of the rate of moving by age in a long running household panel study, the Household, Income and Labour Dynamics in Australia (HILDA) Survey, compared to official cross-sectional data sources and probabilistically linked Census data. Geographic mobility is examined over one-, five- and 10-year periods. Some of the differences that occur in the mobility estimates is a result of item non-response or recall error in the cross-sectional sources but little evidence is found of the differential impact of attrition in the HILDA Survey. There is, however, some indication that the longitudinal survey data underrepresents long distance moves. Other differences between the data sources are investigated by fitting logistic regression models of mobility to estimate the effect of housing tenure and education levels over the life course. These models show similar overall trends, but there is some evidence of differential effects for renters with lower education levels which may be due, at least in part, to the differential role recall error plays in these measures. Overall, these findings reassure longitudinal data users of the quality of geographic mobility estimates from the HILDA Survey and encourage similar comparisons to be made for other longitudinal data sources.
description: Survey Research Methods, Vol 14 No 1 (2020)
Evaluating push-to-web methodology for mixed-mode surveys using address-based samples
Creators: name: Lynn, Peter
Publisher: name: Survey Research Methods
Year: 2020

description: Mixed-mode push-to-web surveys are becoming increasingly popular as a means of combining the desirable but conflicting properties of different data collection modes. Specifically, encouraging as many sample members as possible to participate by web minimises costs, while the use of interviewer-administered modes to follow-up nonrespondents can result in improved response rates. However, push-to-web methodology is still in its infancy. Push-to-web is particularly challenging when only address lists are available as a sampling frame. The article reports the results of a randomised experiment with different ways of handling a) the invitation to all household members at each address, and b) the introduction of the mixed-mode nature of the survey. Furthermore, the push-to-web methods are compared with a traditional face-to-face approach. The experiments are carried out on a national general population sample. Push-to-web is found to be viable though response rates are slightly lower than with face-to-face. Few differences in outcomes are found between the different ways of handling the complexity of the survey context, leading to clear conclusions regarding preferred methods.
description: Survey Research Methods, Vol 14 No 1 (2020)
Effects of Header Images on Different Devices in Web Surveys
Creators: name: Trübner, Miriam
Publisher: name: Survey Research Methods
Year: 2020

description: Header images are typically included in web surveys to make surveys more appealing for respondents. However, headers might also induce a systematic bias in response behavior. In order to examine both the potential effects on engagement and the context effects of header images, an experiment embedded in a web survey on students’ time use and stress was conducted on the basis of a probability sample of 1,326 students at the University of Bonn. Respondents were presented either with a picture of an auditorium with students sitting in class, a picture of leisure activities on campus, or no picture, respectively. To control for position effects, pictures were placed either in the upper right or upper left of the questionnaire. The results show that header images have no effect on survey engagement, but when faced with a header picture, respondents in the picture conditions evaluate their time in class differently compared to respondents in the control group. While the device providing the visibility makes no difference, effects are only significant when the picture is placed on the left side of the screen. In sum, the interaction of header placement and the content-related proximity of header content and question may alter response behavior.
description: Survey Research Methods, Vol 14 No 1 (2020)
Enemy aeroplanes, July 1917 - a clipping from London Magazine, February 1918
Creators: name: Staff Writer, The London Magazine
Publisher: name: University of Victoria Libraries
Year: 2023
Subjects: subject: World War (1914-1918)
valueUri: http://id.worldcat.org/fast/1180746
subject: Air warfare
valueUri: http://id.worldcat.org/fast/802704
subject: Aeronautics, Military
valueUri: http://id.worldcat.org/fast/798542

description: This newspaper clipping is part of the Archie Wills illustrated autobiography. The newspaper caption reads, "Enemy aeroplanes as they approached London in battle formation for the daylight raid in July last. The bombing machines were in the centre, protective battle-planes being on either flank." A handwritten caption from Wills reads "I was in London in July, 1917, when this [?] daylight attack by German [?] took place".
Immunohistochemical biomarkers and FDG uptake on PET/CT in head and neck squamous cell carcinoma
Creators: name: Gregers Brünnich Rasmussen
name: Vogelius, Ivan R.
name: Rasmussen, Jacob H.
name: Schumaker, Lisa
name: Ioffe, Olga
name: Cullen, Kevin
name: Fischer, Barbara Malene
name: Therkildsen, Marianne Hamilton
name: Specht, Lena
name: Bentzen, Søren M.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Neuroscience
subject: Cancer
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Earth and Environmental Sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biophysics

description: Background. There is an exciting complementarity between the spatial resolution provided by molecular imaging of a single, often unspecific, biomarker on one hand and the more detailed biological profile achievable from a diagnostic biopsy using a panel of immunohistochemical (IHC) markers on the other. A number of previous studies have shown a relationship between glucose transport protein expression and 18F-Fludeoxyglucose (FDG) PET uptake. Here, FDG uptake is analyzed in relation to expression of a selected panel of IHC cancer biomarkers in head and neck squamous cell carcinomas (HNSCC).Material and methods. IHC staining for Bcl-2, β-tubulin-1 and 2, p53, EGFR, Ki-67, glutathione-S-transferase-π and p16 was performed on formalin-fixed paraffin embedded diagnostic biopsies from 102 HNSCC cases treated at Rigshospitalet during 2005–2009. The proportion of positive cells was used for analyses, except p16, which was scored according to EORTC guidelines. In all cases, maximal FDG standardized uptake value (SUV) metrics were extracted for the primary tumor, TSUVmax. Univariate linear regression and multiple linear regression of TSUVmax versus IHC markers were performed.Results. In univariate analyses, TSUVmax showed negative associations with Bcl-2 (p = 0.002) and p16 (p = 0.005) indices and positive association with β-tubulin-1 index (p = 0.003). On multivariate analysis, TSUVmax remained associated with β-tubulin-1 (p = 0.009), Bcl-2 (p = 0.03) and p16 (p = 0.03). All correlations had r-squared < 0.3.Conclusion. Statistically significant correlations were observed between the expression of IHC biomarkers and maximum FDG uptake in the primary tumor.
He looks six years younger in that Porsche: do the qualities of products transfer to their owners?
Creators: name: Effendi, R. A. A. Raja Ahmad
name: Whitfield, Allan
Publisher: name: Swinburne
Year: 2024

description: Designed objects acquire and project various qualities through their appearance, materials, price, and advertising. This is clearly apparent in the automotive industry: a Ford 'communicates' a certain message about its product qualities, while a Porsche 'communicates' an entirely different message. Logic leads us to question whether designed objects - in this case cars - do in fact project a specific image or social position that is conferred upon their owners? A considerable body of literature positively answers the first question, yet the second has been neglected. The aim of the current research was to investigate if product qualities are transferred to product owners, by providing empirical evidence showing a shift in third-party perception of an owner when associated with a specific car model. Using a method derived from environmental psychology which demonstrates that the room a person inhabits affects perceptions of that person - the Room Effect - the present research sought to uncover whether the same effect could be demonstrated when associating a person with a product. An internet survey visually depicting (male/female, Asian/Caucasian) owners alongside their (Mercedes Benz/Proton) cars asked respondents to rate the owner on scales representing personality (the Five-Factor Model), physical attributes, and social attributes. Results demonstrated a Product Effect, though not as expected. The effect was most pronounced for the Caucasian male, with lesser effects for the Caucasian and Asian females, and none for the Asian male. The discussion draws on evolutionary and social psychology to provide a plausible explanation for the results.
The Impact of Mixed Modes on Multiple Types of Measurement Error
Creators: name: Sakshaug, Joseph
name: Cernat, Alexandru
Publisher: name: Survey Research Methods
Year: 2020

description: Mixed mode designs are becoming standard in the collection of survey data. Despite this, there are still unknowns regarding how mode (e.g., Web) or mode design (e.g., sequential mixed mode) impacts measurement error. Previous research has been limited by the confounding of selection and measurement mode effects and the investigation of only one type of measurement error at a time. In this paper, we use three waves of the Understanding Society Innovation Panel to investigate whether single-mode versus sequential mixed-mode and Web versus face-to-face modes have different impacts on measurement error. We make use of a quasi-experimental design that randomly allocated respondents to either a unimode face-to-face interview or a sequential mixed-mode (Web and face-to-face) design. Through this design, we implement a new multitrait-multierror model that estimates social desirability, acquiescence, and method effects simultaneously. The results show no differences in measurement error between single modes and mode designs with respect to acquiescence and method effect but some differences are found for social desirability. We discuss the practical implications of these findings and their possible causes in conclusion.
description: Survey Research Methods, Vol 14 No 1 (2020)
Hormonal contraception and sexual desire: A questionnaire-based study of young Swedish women
Creators: name: Malmborg, Agota
name: Persson, Elin
name: Brynhildsen, Jan
name: Hammar, Mats
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Objectives The aim of the study was to determine whether a decrease in sexual desire is more prevalent among women using hormonal contraception than among women using hormone-free contraception, and whether a decrease increases the risk of changing to another contraceptive method. Methods A validated questionnaire was posted to 3740 women (aged 22, 25 or 28 years) living in Sweden. Descriptive statistics were used to present the results; differences between groups were tested using χ2 analyses. A multiple logistic regression model was used for analysis of possible confounders. Results The response rate was 50%. The majority (81%) of respondents used some kind of contraception, and 88% were generally satisfied with the method used. Regardless of the type of method, 27% of hormonal contraceptive users reported a decrease in sexual desire that they attributed to their use of hormonal contraception, whereas only 12% of women using hormone-free contraception reported a decrease in sexual desire (p<0.01). This twofold risk of a decrease in sexual desire was shown in the multiple regression analysis to be independent of age group, depression, BMI, educational level and parity. However, having a partner was found to be a factor of equal importance: women with partners experienced reduced desire twice as often as women without partners. The observed odds ratio for planning to stop hormonal contraception or to change to a different type due to reduced desire was 8.16 (95% confidence interval 6.65-10.1) among women who had had the same experience during a previous period of hormonal contraceptive use. Conclusions Women using hormonal contraception were more likely to experience reduced sexual desire compared with women using hormone-free contraception. Experiencing reduced desire was a strong predictive factor for women to change contraceptive method.
Role of pharmacogenetics of drug-metabolizing enzymes in treating osteosarcoma
Creators: name: Serra, Massimo
name: Hattinger, Claudia Maria
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Biological Sciences
subject: Biotechnology
subject: Pharmacology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biochemistry

description: Introduction: Drug-metabolizing enzymes (DMEs) biotransform several toxins and xenobiotics in both tumor and normal cells, resulting in either their detoxification or their activation. Since DMEs also metabolize several chemotherapeutic drugs, they can significantly influence tumor response to chemotherapy and susceptibility of normal tissues to collateral toxicity of anticancer treatments.Areas covered: This review discusses the pharmacogenetics of DMEs involved in the metabolism of drugs which constitute the backbone of osteosarcoma (OS) chemotherapy, highlighting what is presently known for this tumor and their possible impact on the modulation of future treatment approaches.Expert opinion: Achieving further insight into pharmacogenetic markers and biological determinants related to treatment response in OS may ultimately lead to individualized treatment regimens, based on a combination of genotype and tumor characteristics of each patient.
Turcinoemacheilus hafezi Golzarianpour, Abdoli, Patimar & Freyhof 2013
Creators: name: Sayyadzadeh, Golnaz
name: Esmaeili, Hamid Reza
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Cypriniformes
Nemacheilidae
Turcinoemacheilus
Turcinoemacheilus hafezi

description: 74. Turcinoemacheilus hafezi Golzarianpour, Abdoli, Patimar & Freyhof, 2013
Common name. Hafez dwarf loach
Taxonomy. Original description: Turcinoemacheilus hafezi Golzarianpour, Abdoli, Patimar & Freyhof, 2013: 43, figs. 1-6, 8 [tream at Joneqon, tributary of Kohrang River, Iran, 32°05'22"N, 50°39'48"E; holotype: ZFMK 48841].
Revisions. None.
Illustrations. Golzarianpour et al. (2013: 43, fig. 1).
Distribution in Iran. —Distribution in River Basin: Tigris.—Distribution in Ecoregions: 442-Upper Tigris & Euphrates.
Status in Iran. [Endemic].—Loch mahi-e kotolye Hafez.—Listed in previous checklists from Iran by Esmaeili et al. (2017 a, 2018); Jouladeh-Roudbar et al. (2020) and Eagderi et al. (2022).—Iran material: ZFMK, ZM-CBSU.
Conservation. —IUCN: NE.
description: Published as part of Sayyadzadeh, Golnaz & Esmaeili, Hamid Reza, 2024, Freshwater lamprey and fishes of Iran: Reappraisal and updated checklist with a note on Eagderi et al. (2022), pp. 1-99 in Zootaxa 5402 (1) on pages 29-30, DOI: 10.11646/zootaxa.5402.1.1, http://zenodo.org/record/10524097
The design and usability testing of DACADE - A tool supporting systematic data collection and analysis for design students
Creators: name: Sheikh Abdul Aziz, Madihah
name: Lindgaard, Gitte
name: Whitfield, Allan
Publisher: name: Swinburne
Year: 2024

description: Norman claims that designers are bereft of statistical knowledge to perform effectively, stating that designers must understand technology, business and psychology to support design decisions. For designers to acquire the necessary statistical skills, design curricula should incorporate statistical courses teaching systematic data collection and data analysis. This paper presents the development and formative usability tests of the prototypes of a software tool called DACADE intended to support design students collecting and analyzing data systematically early in the design phase. It uses a 2D map and a Napping(R) technique to support effective and efficient communication between designers and target audiences in the design decision process by providing visual data and descriptive statistics without needing statistical knowledge.
Interpreting atomic force microscopy measurements of hydrodynamic and surface forces with nonlinear parametric estimation
Creators: name: Cui, Song
name: Manica, Rogerio
name: Tabor, Rico F.
name: Chan, Derek
Publisher: name: Swinburne
Year: 2024

description: A nonlinear parameter estimation method has been developed to extract the separation-dependent surface force and cantilever spring constant from atomic force microscope data taken at different speeds for the interaction between a silica colloidal probe and plate in aqueous solution. The distinguishing feature of this approach is that it exploits information from the velocity dependence of the force-displacement data due to hydrodynamic interaction to provide an unbiased estimate of the functional form of the separation-dependent surface force. An assumed function for the surface force with unknown parameters is not required. In addition, the analysis also yields a consistent estimate of the in situ cantilever spring constant. In combination with data from static force measurements, this approach can further be used to quantify the extent of hydrodynamic slip.
Stokesian dynamics of pill-shaped Janus particles with stick and slip boundary conditions
Creators: name: Sun, Qiang
name: Klaseboer, Evert
name: Khoo, Boo Cheong
name: Chan, Derek
Publisher: name: Swinburne
Year: 2024

description: We study the forces and torques experienced by pill-shaped Janus particles of different aspect ratios where half of the surface obeys the no-slip boundary condition and the other half obeys the Navier slip condition of varying slip lengths. Using a recently developed boundary integral formulation whereby the traditional singular behavior of this approach is removed analytically, we quantify the strength of the forces and torques experienced by such particles in a uniform flow field in the Stokes regime. Depending on the aspect ratio and the slip length, the force transverse to the flow direction can change sign. This is a novel property unique to the Janus nature of the particles.
Locative media: From specialized preoccupation to mainstream fascination
Creators: name: Wilken, Rowan
Publisher: name: Swinburne
Year: 2024

description: In 2010, Google generated global controversy when their Google Street View cars recorded data sourced from unsecured WiFi networks. While, in February of the same year, mobile social networking service Foursquare became embroiled in its own controversy when it was revealed that much of the traffic on their site was appearing on Please Rob Me.com, a website which streams updates from various location-based networks that shows when users check-in to a geographical location that is not their home. These controversies are of note not just for the salutary lessons they offer about the risks associated with digital data retention, privacy and security. At a more general level, they are noteworthy in that they testify to the dramatically increased public awareness of, and mainstream (especially press) exposure granted to, location-based media services.
Local institutions and local economic development in Guto Gidda district, Oromia region, Ethiopia
Creators: name: Walo, Megerssa
Publisher: name: Swinburne
Year: 2024

description: Local institutions can facilitate local economic development (LED) processes by reducing transaction costs, enhancing social capital, and creating enabling environments for business to flourish. However, factors such as the actors’ preference to accept and practice one type of institutions over the other, and the nature of the functional linkages between the different kinds of institutions influence the role they play in development processes. This study empirically investigates the contributions of institutions to local economic development processes in the Guto Gidda district of the Oromia region, Ethiopia, using an institutional analysis of a case study. A qualitative research approach using in-depth interviews with local development actors was employed to collect the data. Results show that local development actors prefer to practice indigenous institutions over government institutions because they offer more accessible services and are less reliant on ruling party affiliation. There were weak functional linkages between the two types of institutions, which had a negative development impact on the locality. The paper recommends mutual and collaborative functional linkages between the local institutions to maximize the contributions of both to LED.
A case of sharing competences via a Collaborative Digital Network
Creators: name: Cheung, Y. P.
name: Lee, V. C. S.
name: Scheepers, Helana
name: Bal, J.
Publisher: name: Swinburne
Year: 2024

description: Based on a successful implementation of a Collaborative Digital Network (CDN) the West Midlands Collaborative Commerce Marketplace (WMCCM, http://www.wmccm.com), this paper presents a breeding environment to enable stakeholders to innovate and gain competitive advantage in the global market. Stakeholders in a CDN form Communities of Practice (CoPs) and they collectively belong to an Electronic Network of Practice (ENoP) formed via ICT. Business opportunities are gained via sharing of resources and core competences, including innovative ideas and capabilities. Three cases from the WMCCM are presented to illustrate the concept. Though aimed at rejuvenating failing SMEs in the UK, the WMCCM concept can be applied to other regions of the world. Current work involves developing theories for CDNs as well as extending the WMCCM concept to other regions of the world.
Considerations when using pharmacokinetic/pharmacodynamic modeling to determine the effectiveness of simple analgesics in children
Creators: name: Anderson, Brian J
name: Hannam, Jacqueline A
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Genetics
subject: FOS: Biological sciences
subject: Medicine

description: Introduction: Assessment of analgesic drugs includes comparative studies to other analgesics and local anesthesia blockade, number needed to treat estimates and opioid sparing descriptions. An additional methodology is to define the concentration–response relationship using pharmacokinetic/pharmacodynamic (PK/PD) modeling.Areas covered: A concentration–response relationship allows analgesic effect comparison between drugs for different acute pain types. Covariates such as size, age and organ function impact greatly on PK in children. The cumulative effect of confounding factors (e.g., pharmacogenetics, placebo and changes in baseline pain over time) complicates PD. Other factors (outcome measures, method of measurement, failure to account for study attrition) impact on outcome. Population PK/PD modeling approaches allow us to account for these various factors to some extent.Expert opinion: Nonlinear mixed effects models help interpret analgesic data and their use is increasing. The PK is relatively well understood. The next investigative step will involve investigation into covariate effects for PD. Mathematical functions for both placebo models and dropout models are well described and should be incorporated into analgesic effectiveness studies that investigate a range of doses. Improvements in pain assessment tools and a greater understanding of pharmacogenomics factors will help individualize analgesic therapy.
Highly Sensitive Fluorescent Probe for Selective Detection of Hg2+
Creators: name: Ding, De-Gang
name: Wang, Jian-Ling
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Science Policy
Biological Sciences
Chemistry
Earth and Environmental Sciences
Molecular Biology
Cell Biology
Biochemistry
Biophysics

description: A selective and sensitive chromogenic and fluorogenic dual signal responding fluoride-sensor (L), comprising the well-known rhodamine 6G fluorophore and 2,2′-bipyridine was prepared and spectroscopically characterized. After mercury ion was added to the CH3CN solution of L, a color change from colorless to pink-red, which indicated that the sensor can serve as a sensitive “naked-eye” indicator for mercury ion. The high emission selectivity is due to the formation of L-Hg2+ 1:2 complex leads to spirocycle opening of L.
Corporate governance mechanisms and their impact on company performance: A structural equation model analysis
Creators: name: Azim, Mohammad
Publisher: name: Swinburne
Year: 2024

description: The purpose of this study is to use structural equation modelling (SEM) to investigate the extent to which different monitoring mechanisms - the board and its committees, shareholders and independent auditors - are complements (i.e. a positive covariance) or substitutes (a negative covariance) for each other. The lack of consistent results in previous corporate governance research may be attributable to attention not being paid to monitoring mechanisms' substitution or complementary relationships. By using SEM, this study concludes that complementary and substitution relationships among monitoring mechanisms are present. Using data from the pre – and post – global financial crisis period, this study explains where such corporate government impacts occurred, the inconsistencies that are evident in previous studies and provides insights into corporate governance practices.
Understanding organizational barriers influencing local electronic government adoption and implementation: The electronic government implementation framework
Creators: name: Nurdin, Nurdin
name: Stockdale, Rosemary
name: Scheepers, Helana
Publisher: name: Swinburne
Year: 2024

description: Researchers in electronic government have indicated a number of organizational barriers that hinder the adoption and implementation of electronic government. This paper proposes a research framework for analysing how organizational barriers influence the adoption and implementation of e-government at local levels. The framework is constructed based on four organizational dimensions; adaptability, involvement, mission, and bureaucracy drawn from organizational theories and e-government literature. We found that organizational barriers which are identified in major e-government literature link to the dimensions of organizational culture and effectiveness. Our conclusion is that the framework is relevant to understand organizational barriers influencing adoption and implementation of local e-government. The limitation of this study is that the framework has been developed based on the application of a theoretical lens on the e-government literature. It is now necessary to test this model in different contexts.
Remodeling of extracellular matrix due to solid stress accumulation during tumor growth
Creators: name: Papageorgis, Panagiotis
name: Chrysovalantis Voutouri
name: Mpekris, Fotios
name: Stylianopoulos, Triantafyllos
name: Pirentis, Athanassios P.
name: Polydorou, Christiana
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Developmental Biology
subject: Mathematics
subject: FOS: Mathematics
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Biotechnology
subject: Medicine
subject: Biophysics

description: Solid stresses emerge as the expanding tumor displaces and deforms the surrounding normal tissue, and also as a result of intratumoral component interplay. Among other things, solid stresses are known to induce extensive extracellular matrix synthesis and reorganization. In this study, we developed a mathematical model of tumor growth that distinguishes the contribution to stress generation by collagenous and non-collagenous tumor structural components, and also investigates collagen fiber remodeling exclusively due to solid stress. To this end, we initially conducted in vivo experiments using an orthotopic mouse model for breast cancer to monitor primary tumor growth and derive the mechanical properties of the tumor. Subsequently, we fitted the mathematical model to experimental data to determine values of the model parameters. According to the model, intratumoral solid stress is compressive, whereas extratumoral stress in the tumor vicinity is compressive in the radial direction and tensile in the periphery. Furthermore, collagen fibers engaged in stress generation only in the peritumoral region, and not in the interior where they were slackened due to the compressive stress state. Peritumoral fibers were driven away from the radial direction, tended to realign tangent to the tumor–host interface, and were also significantly stretched by tensile circumferential stresses. By means of this remodeling, the model predicts that the tumor is enveloped by a progressively thickening capsule of collagen fibers. This prediction is consistent with long-standing observations of tumor encapsulation and histologic sections that we performed, and it further corroborates the expansive growth hypothesis for the capsule formation.
The influence of external institutional pressures on local e-government adoption and implementation: A coercive perspective within an indonesian local e-government context
Creators: name: Nurdin, Nurdin
name: Stockdale, Rosemary
name: Scheepers, Helana
Publisher: name: Swinburne
Year: 2024

description: Adoption and implementation of e-government within local government organizations are influenced by many external factors. These factors are often perceived as forces or pressures that influence local government decisions to adopt and implement the initiatives. This study uses the concept of coercive force from institutional theory to explain those external pressures influencing e-government adoption and implementation within a local government in Bali province in Indonesia. An interpretive case study approach is adopted to empirically understand the external pressures on local government adoption and implementation of e-government. Our findings show that four institutional external forces, central government, regulations, local citizens and limitation in financial resources, have strongly influenced the regency to adopt and implement e-government systems to improve their administration and services performance.
Netchain analysis of maize and niger seed value chains and local economic development in Nekemte and its hinterlands, Oromia, Ethiopia
Creators: name: Walo, Megerssa
Publisher: name: Swinburne
Year: 2024

description: This paper proposes the netchain approach to analyze rural-urban linkages and local economic
development (LED) in Guto Gidda district, Oromia, Ethiopia using maize and niger seed. The
traditional methods of value chain, supply chain and network fail to analyze these multifaceted
linkages simultaneously. While value and supply chains analyze linear relationships between a
firm and its buyers and suppliers (vertical linkages), networks study relationships among firms with common goals (horizontal linkages). The study draws on empirical data obtained through in-depth interviews with farm households, traders, small-scale manufacturers and agriculture
offices in both Nekemte Town and its hinterlands. Results suggest that farmers’ inefficient
agricultural practices, high costs and limited access to agricultural inputs, and lack or shortage of
farmland influenced grain production. Traders/intermediaries dominate the grain marketing at
the expense of the farmers. Grain processing is characterized by traditional and small crushers with inadequate capacity, low hygiene and lack of safety standards. Improving farmers’ accessibility to affordable input supply and reliable market information; encouraging processors through credit and power supply; and strengthening social capital through mutual trust among the agents stimulates the netchain and LED.
Why did People Bury Things? Depositional Practices from the Late Neolithic through the Bronze Age in Britain.
Creators: name: Gubbins, Nathan
Publisher: name: University of Leicester
Year: 2024

description: The topic of prehistoric depositional practices has been shaped by an adherence to a post enlightenment and capitalist world view that casts them as either the result of economic or domestic practice verses meaningful and symbolically laden ritual. Furthermore, change in these practices have often been considered under the lens of chronological evolutionary models that treats the Neolithic and the Bronze Age as distinct periods of time. This, I argue has led to a demarcation in our understanding of past depositional practices.In this thesis I consider the study of a range of depositional practices from the Neolithic to the Bronze Age in Britain. I present a critique of existing approaches to depositional practice and offer New Materialism as an alternative route to understanding these past practices. In doing so I will provide critical overview of approaches such as ‘structured deposition’ as well as categories such as hoard and rubbish pit. In doing so I argue that we need to begin our analysis of depositional practices with a flat ontology. As a result, I offer interpretations of depositional practices that are not anthropocentric, do not rely on binaries, and reject material hierarchies. I also consider how these practices change and will offer a critique of the prevailing linear chronological models of technological and social evolution and instead utilise concepts such as emergent causation and duration inspired by Deleuze’s engagement with Henri Bergson.To conclude, I argue that deposition was part of a continuum of iterative processes that are continually being renegotiated over the course of the Neolithic and Bronze Ages.
Gaussian copula distributions for mixed data, with application in discrimination
Creators: name: F. Jiryaie
name: N. Withanage
name: B. Wu
name: A.R. De Leon
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Inorganic Chemistry
subject: Plant Biology
subject: Computational Biology

description: The construction of a joint model for mixed discrete and continuous random variables that accounts for their associations is an important statistical problem in many practical applications. In this paper, we use copulas to construct a class of joint distributions of mixed discrete and continuous random variables. In particular, we employ the Gaussian copula to generate joint distributions for mixed variables. Examples include the robit-normal and probit-normal-exponential distributions, the first for modelling the distribution of mixed binary-continuous data and the second for a mixture of continuous, binary and trichotomous variables. The new class of joint distributions is general enough to include many mixed-data models currently available. We study properties of the distributions and outline likelihood estimation; a small simulation study is used to investigate the finite-sample properties of estimates obtained by full and pairwise likelihood methods. Finally, we present an application to discriminant analysis of multiple correlated binary and continuous data from a study involving advanced breast cancer patients.
Highly Sensitive Fluorescent Probe for Selective Detection of Hg2+
Creators: name: Ding, De-Gang
name: Wang, Jian-Ling
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Science Policy
Biological Sciences
Chemistry
Earth and Environmental Sciences
Molecular Biology
Cell Biology
Biochemistry
Biophysics

description: A selective and sensitive chromogenic and fluorogenic dual signal responding fluoride-sensor (L), comprising the well-known Rhodamine 6G fluorophore and 2,2’-bipyridine was prepared and spectroscopically characterized. After mercury ion was added to the CH3CN solution of L, a color change from colorless to pink-red, which indicated that the sensor can serve as a sensitive “naked-eye” indicator for mercury ion. The high emission selectivity is due to the formation of L-Hg2+ 1:2 complex leading to spirocycle opening of L.
A framework for service recipient inclusion in community IT projects
Creators: name: Felstead, Chris
name: Stockdale, Rosemary
Publisher: name: Swinburne
Year: 2024

description: Not-for-profit organizations put considerable effort into community-based Information Technology (IT) projects to bridge the gap between the 'haves and the 'have-nots' of the digital divide. However, the outcomes of these IT projects are often seen as problematic with service recipients failing to gain the intended benefits. It is proposed that this is often because the recipients fail to be engaged as a result of being ascribed with belonging to a community without the perceived power or ability to participate. It is also proposed that this is an area for further study with a bias towards using Participatory Design Techniques in conjunction with the model suggested in this paper. The researchers believe that this could provide an area of investigation for an Action Research project.
GBA deficiency promotes SNCA/α-synuclein accumulation through autophagic inhibition by inactivated PPP2A
Creators: name: Du, Ting-Ting
name: Wang, Le
name: Duan, Chun-Li
name: Lu, Ling-Ling
name: Zhang, Jian-Liang
name: Gao, Ge
name: Qiu, Xiao-Bo
name: Wang, Xiao-Min
name: Yang, Hui
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Physiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Microbiology

description: Loss-of-function mutations in the gene encoding GBA (glucocerebrosidase, beta, acid), the enzyme deficient in the lysosomal storage disorder Gaucher disease, elevate the risk of Parkinson disease (PD), which is characterized by the misprocessing of SNCA/α-synuclein. However, the mechanistic link between GBA deficiency and SNCA accumulation remains poorly understood. In this study, we found that loss of GBA function resulted in increased levels of SNCA via inhibition of the autophagic pathway in SK-N-SH neuroblastoma cells, primary rat cortical neurons, or the rat striatum. Furthermore, expression of the autophagy pathway component BECN1 was downregulated as a result of the GBA knockdown-induced decrease in glucocerebrosidase activity. Most importantly, inhibition of autophagy by loss of GBA function was associated with PPP2A (protein phosphatase 2A) inactivation via Tyr307 phosphorylation. C2-ceramide (C2), a PPP2A agonist, activated autophagy in GBA-silenced cells, while GBA knockdown-induced SNCA accumulation was reversed by C2 or rapamycin (an autophagy inducer), suggesting that PPP2A plays an important role in the GBA knockdown-mediated inhibition of autophagy. These findings demonstrate that loss of GBA function may contribute to SNCA accumulation through inhibition of autophagy via PPP2A inactivation, thereby providing a mechanistic basis for the increased PD risk associated with GBA deficiency.