cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Compton-Thick AGN in the NuSTAR era VIII: A joint NuSTAR-XMM-Newton monitoring of the changing-look Compton-thick AGN NGC 1358
Creators: name: Marchesi, Stefano
name: Zhao, Xiurui
name: Torres-Albà, Núria
name: Ajello, Marco
name: Gaspari, Massimo
name: Pizzetti, Andrealuna
name: Buchner, Johannes
name: Bertola, Elena
name: Comastri, Andrea
name: Feltre, Anna
name: Gilli, Roberto
name: Lanzuisi, Giorgio
name: Matzeu, Gabriele
name: Pozzi, Francesca
name: Salvestrini, Francesco
name: Sengupta, Dhrubojyoti
name: Silver, Ross
name: Tombesi, Francesco
name: Traina, Alberto
name: Vignali, Cristian
name: Zappacosta, Luca
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present the multi-epoch monitoring with NuSTAR and XMM-Newton of NGC 1358, a nearby Seyfert 2 galaxy whose properties made it a promising candidate X-ray changing look AGN, i.e., a source whose column density could transition from its 2017 Compton-thick (CT-, having line-of-sight Hydrogen column density NH,los>10^24 cm^-2) state to a Compton-thin (NH,los<10^24 cm^-2) one. The multi-epoch X-ray monitoring confirmed the presence of significant NH,los variability over time-scales as short as weeks, and allowed us to confirm the "changing look" nature of NGC 1358, which has most recently been observed in a Compton-thin status. Multi-epoch monitoring with NuSTAR and XMM-Newton is demonstrated to be highly effective in simultaneously constraining three otherwise highly degenerate parameters: the torus average column density and covering factor, and the inclination angle between the torus axis and the observer. We find a tentative anti-correlation between column density and luminosity, which can be understood in the framework of Chaotic Cold Accretion clouds driving recursive AGN feedback. The monitoring campaign of NGC 1358 has proven the efficiency of our newly developed method to select candidate NH,los-variable, heavily obscured AGN, which we plan to soon extend to a larger sample to better characterize the properties of the obscuring material surrounding accreting supermassive black holes, as well as constrain AGN feeding models.
description: 24 pages, 13 figures: main results in Figures 4, 7, 8 and 9. Accepted for publication in the Astrophysical Journal
Incidence and Risk Factors for Pelvic Pain After Mesh Implant Surgery for the Treatment of Pelvic Floor Disorders
Creators: name: Babb, Emma
name: Zolnoun, Denniz
name: Geller, Elizabeth J.
name: Nackley, Andrea G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Our aim was to assess incidence and risk factors for pelvic pain after pelvic mesh implantation.
title: Kachexie und Ödeme: Grund für stationäre Aufnahme?
Creators: name: Sturm, Andreas
name: Singh, Delila
name: Hartmann, Johannes
name: Bogner, Johannes
name: Bauer, Axel
name: Skapenko, Alla
name: Dechant, Claudia
name: Schulze-Koops, Hendrik
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Vorgeschichte: Bei einem 74-jährigen Patienten warenvor einem Jahr ein ungewollter Gewichtsverlust (12 kg), Extremitätenödeme und eine Allgemeinzustandsverschlechterung aufgetreten. Seit 17 Jahren war eine homozygote Hämochromatose bekannt. Bei seit zwei Jahren bekannter Anämie[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Quasinormal modes and the correspondence with shadow in black holes with a deficit solid angle and quintessence-like matter
Creators: name: Yu, Chengye
name: Chen, Deyou
name: Gao, Chuanhong
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this paper, we investigate the photon sphere, shadow radius and quasinormal modes of a $4$-dimensional black hole with a deficit solid angle and quintessence-like matter. We find that the radii of the photon sphere and shadow decrease with the decreases of the deficit solid angle and density of quintessence-like matter. The quasinormal modes are gotten by the sixth order WKB approximation method and shadow radius, respectively. The values of the real part and imaginary parts of the quasinormal modes increase with the decrease of the values of the deficit solid angle and density of quintessence-like matter when the multipole number is fixed. The quasinormal modes gotten by these two methods are in good agreement, especially when the multipole number is large. It shows the correspondence between the quasinormal modes in the eikonal limit and shadow.
description: 18 pages. arXiv admin note: text overlap with arXiv:2106.13548
title: Und plötzlich waren die Finger schwarz – kein Fall einer systemischen Sklerose
Creators: name: Hasseli, Rebecca
name: Diller, Magnus
name: Tarner, Ingo H.
name: Müller-Ladner, Ulf
name: Hermann, Walter
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Eine 73-jährige Patientin entwickelte während eines Urlaubs plötzlich eine Raynaud-Symptomatik an der linken Hand, welche im Verlauf auch die rechte Hand betraf. Radiographisch und neurologisch ergab sich kein wegweisender Befund. Zur weiteren Abklärung stellte sie sich gefäßchirurgisch[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
A spatially resolved study of hard X-ray emission in Kepler's SNR: indications of different regimes of particle acceleration
Creators: name: Sapienza, Vincenzo
name: Miceli, Marco
name: Bamba, Aya
name: Katsuda, Satoru
name: Nagayoshi, Tsutomu
name: Terada, Yukikatsu
name: Bocchino, Fabrizio
name: Orlando, Salvatore
name: Peres, Giovanni
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Synchrotron X-ray emission in young supernova remnants (SNRs) is a powerful diagnostic tool to study the population of high energy electrons accelerated at the shock front and the acceleration process. We performed a spatially resolved spectral analysis of NuSTAR and XMM-Newton observations of the young Kepler's SNR, aiming to study in detail its non-thermal emission in hard X-rays. We selected a set of regions all around the rim of the shell and extracted the corresponding spectra. The spectra were analyzed by adopting a model of synchrotron radiation in the loss-limited regime, to constrain the dependence of the cutoff energy of the synchrotron radiation on the shock velocity. We identify two different regimes of particle acceleration, characterized by different Bohm factors. In the north, where the shock interacts with a dense circumstellar medium (CSM), we found a more efficient acceleration than in the south, where the shock velocity is higher and there are no signs of shock interaction with dense CSM. Our results suggest an enhanced efficiency of the acceleration process in regions where the shock-CSM interaction generates an amplified and turbulent magnetic field. By combining hard X-ray spectra with radio and $γ-$ray observations of Kepler's SNR, we modelled the spectral energy distribution. In the light of our results we propose that the observed $γ-$ray emission is mainly hadronic, and originates in the northern part of the shell.
description: 16 pages, 7 figures, 5 tables, Accepted for publication in ApJ
Mapping the Interaction Network of Key Proteins Involved in Histone mRNA Generation: A Hydrogen/Deuterium Exchange Study
Creators: name: Skrajna, Aleksandra
name: Marzluff, William F.
name: Yang, Xiao-Cui
name: Tarnowski, Krzysztof
name: Fituch, Kinga
name: Dominski, Zbigniew
name: Dadlez, Michał
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Histone pre-mRNAs are cleaved at the 3′ end by a complex that contains U7 snRNP, the FLICE-Associated Huge protein (FLASH) and Histone pre-mRNA Cleavage Complex (HCC) consisting of several polyadenylation factors. Within the complex, the N-terminus of FLASH interacts with the N-terminus of the U7 snRNP protein Lsm11 and together they recruit the HCC. FLASH through its distant C-terminus independently interacts with the C-terminal SANT/Myb-like domain of Nuclear Protein, Ataxia-Telangiectasia locus (NPAT), a transcriptional co-activator required for expression of histone genes in S-phase. To gain structural information on these interactions, we used mass spectrometry to monitor hydrogen/deuterium (H/D) exchange in various regions of FLASH, Lsm11 and NPAT alone or in the presence of their respective binding partners. Our results indicate that the FLASH-interacting domain in Lsm11 is highly dynamic, while the more downstream region required for recruiting the HCC exchanges deuterium slowly and likely folds into a stable structure. In FLASH, a stable structure is adopted by the domain that interacts with Lsm11 and this domain is further stabilized by binding Lsm11. Notably, both H/D exchange experiments and in vitro binding assays demonstrate that Lsm11, in addition to interacting with the N-terminal region of FLASH, also contacts the C-terminal SANT/Myb-like domain of FLASH, the same region that binds NPAT. However, while NPAT stabilizes this domain, Lsm11 causes its partial relaxation. These competing reactions may play a role in regulating histone gene expression in vivo.
The ALPINE-ALMA [CII] survey: The infrared-radio correlation and AGN fraction of star-forming galaxies at z $\sim$ 4.4-5.9
Creators: name: Shen, Lu
name: Lemaux, Brian C.
name: Lubin, Lori M.
name: Liu, Guilin
name: Béthermin, Matthieu
name: Boquien, Médéric
name: Cucciati, Olga
name: Fèvre, Olivier Le
name: Talia, Margherita
name: Vergani, Daniela
name: Zamorani, Gianni
name: Faisst, Andreas L.
name: Ginolfi, Michele
name: Gruppioni, Carlotta
name: Jones, Gareth C.
name: Bardelli, Sandro
name: Hathi, Nimish
name: Koekemoer, Anton M.
name: Romano, Michael
name: Schaerer, Daniel
name: Zucca, Elena
name: Fang, Wenjuan
name: Forrest, Ben
name: Gal, Roy
name: Hung, Denise
name: Shah, Ekta A.
name: Staab, Priti
name: Vanderhoof, Brittany
name: Ibar, Eduardo
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present the radio properties of 66 spectroscopically-confirmed normal star-forming galaxies (SFGs) at $4.4
description: Accepted for publication in Astrophysical Journal, 22 pages, 5 figure
Knowledge and Beliefs among First Responders (Physiotherapists, Coaches and Athletic Trainers) and its Influence on Initial Management of Sports-Related Concussions – Systematic Review
Creators: name: Sandhu, Jasdeep
name: De Leon, Alen Joshua
name: Boncato, Joshua Peter
name: Phillips, Jennifer
name: Gough, Suzanne
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Medicine and Health Sciences
subject: Athletic Trainer
subject: Beliefs
subject: Coach
subject: Concussion
subject: First Responders
subject: Initial Management
subject: Knowledge
subject: Physiotherapist
subject: Sports Related Concussion

description: Sports related concussions (SCR) has remained a prevalent, if not growing concern within the sporting community. US centers for Disease Control and Prevention, estimates that there is a yearly occurrence of 1.6 million to 3.8 million concussions which arise from sport and recreational activities (Sahler & Greenwald, 2012). These implications are further emphasised by the detrimental effects towards the individual, who can endure both cognitive and physical impairments (Manley et al., 2017). Despite this growing concern, the management of concussion remains vague and unclear. Currently there is no universal standardized guidelines for concussion assessment/management (Albicini & McKinlay, 2018), which can create disparities towards various stakeholders of sport particularly towards the initial stage of injury(Scorza & Cole, 2019). This review aims to identify the current knowledge and beliefs among first responders (Physiotherapist Coaches and Athletic trainers) and explore its influence on initial management of sports related concussions. The current body of literature, although insightful, primarily focuses on examining how these professions separately manage SRCs (Guo et al., 2019; Naftel et al., 2014; O'Connor et al., 2021; Salmon et al., 2023; Sarmiento et al., 2019; White et al., 2014; Yeo et al., 2020; Yorke et al., 2016). However, there remains a distinct need for comprehensive comparative research to shed light on potential disparities and synergies with the inter-professional team. Ultimately, these review findings can yield benefit for policy makers, healthcare practitioners and sporting organisations towards a gold standard of care. Identifying potential knowledge gaps between professionals can lead to targeted educational programs to enhance understandings of concussion. Whilst insights into first responder beliefs can influence the viability of current guidelines and identify recommendations for the future.
title: Ein unklares Geschwür
Creators: name: Hasseli, Rebecca
name: Diller, Magnus
name: Tarner, Ingo H.
name: Lange, Uwe
name: Müller-Ladner, Ulf
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Ein 82-jähriger Patient entwickelte spontan offene Hautläsionen an beiden Unterschenkeln. Die Hautläsionen waren über die Zeit progredient, so dass sie eine Größe von ca. 30 x 15 cm und eine nahezu komplette Skelettierung bis zu den Sehnen und Muskeln mit Rollstuhlpflicht[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Bayesian hierarchical modelling for inferring genetic interactions in yeast
Creators: name: Heydari, Jonathan
name: Lawless, Conor
name: Lydall, David A.
name: Wilkinson, Darren J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantitative Methods (q-bio.QM)
subject: Genomics (q-bio.GN)
subject: Applications (stat.AP)
subject: FOS: Biological sciences
subject: FOS: Computer and information sciences

description: Quantitative Fitness Analysis (QFA) is a high-throughput experimental and computational methodology for measuring the growth of microbial populations. QFA screens can be used to compare the health of cell populations with and without a mutation in a query gene in order to infer genetic interaction strengths genome-wide, examining thousands of separate genotypes. We introduce Bayesian, hierarchical models of population growth rates and genetic interactions that better reflect QFA experimental design than current approaches. Our new approach models population dynamics and genetic interaction simultaneously, thereby avoiding passing information between models via a univariate fitness summary. Matching experimental structure more closely, Bayesian hierarchical approaches use data more efficiently and find new evidence for genes which interact with yeast telomeres within a published dataset.
description: To appear in Journal of Royal Statistical Society, Series C
The Structural Basis of Actin Organization by Vinculin and Metavinculin
Creators: name: Campbell, Sharon L.
name: Pershad, Mihir
name: Alushin, Gregory M.
name: Thompson, Peter M.
name: Lee, Hyunna T.
name: Kim, Laura Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Vinculin is an essential adhesion protein that links membrane-bound integrin and cadherin receptors through their intracellular binding partners to filamentous actin, facilitating mechanotransduction. Here we present an 8.5-Å-resolution cryo-electron microscopy reconstruction and pseudo-atomic model of the vinculin tail (Vt) domain bound to F-actin. Upon actin engagement, the N-terminal "strap" and helix 1 are displaced from the Vt helical bundle to mediate actin bundling. We find that an analogous conformational change also occurs in the H1' helix of the tail domain of metavinculin (MVt) upon actin binding, a muscle-specific splice isoform that suppresses actin bundling by Vt. These data support a model in which metavinculin tunes the actin bundling activity of vinculin in a tissue-specific manner, providing a mechanistic framework for understanding metavinculin mutations associated with hereditary cardiomyopathies.
title: Rezidivierende posttraumatische Osteomyelitis am Tibiakopf bei einer Patientin mit seropositiver Rheumatoidarthritis
Creators: name: Scholz, Roger
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Schwere lokale ossäre Infekte treten bei immunsupprimierten Patienten häufiger auf. Ihre Sanierung ist oftmals langwierig, die Rezidivgefahr hoch und die Fortführung einer immunsup-primierenden Basistherapie daher eher kritisch zu bewerten. Eine suffiziente medikamentöse[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Entrepreneurial fear of failure: An international comparison of antecedents and impact on venture creation Chapman, P. and Phillips, R.A. (2022) Journal of the International Council for Small Business Vol 3(4) pp. 281-291.
Creators: name: Phillips, Robert
Publisher: name: University of Manchester
Year: 2022
Subjects: Entrepreneurship

description: Fear of failure is a key barrier in starting a business throughout the world due to the high risks involved to the founders’ finances, relationships, status, and self-esteem. Using Global Entrepreneurship Monitor data, it was observed that countries with high fear of failure have low total early-stage entrepreneurial activity for developed countries only, and that the gap between the ratio of men to women entrepreneurs in countries with high fear of failure is narrower. Countries with higher self-perceived capabilities are lower in fear of failure. However, societal norms, education, access to funding, and perceived government policy had little effect. Countries with greater economic development seem lower in fear of failure than those less developed and the higher the rate of necessity-driven entrepreneurship, the less relevant fear of failure becomes in inhibiting entrepreneurship. This article aims to understand which factors can influence fear of failure to allow governments to put in place policies to reduce this as a barrier to start-ups, which ultimately influences the country’s prospects for economic growth. This article can be used to encourage policies that can be tailored to each country’s unique ecosystem based on the underlying reasons for fear of failure in that country.
title: Rezidivierende ulzerierende Cystitis unter Biologica Therapie bei rheumatoider Arthritis
Creators: name: Braun, Matthias
name: Stoll, Matthias
name: Al-Mwalad, Mohamed
name: Hartig, Ingo
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Infekte stellen eine Komplikation einer immunsuppressiven Therapie bei Patienten (Pat.) mit rheumatoider Arthritis dar. Kasuistik: Bei einer 38-jährigen Pat. wurde 1997 eine seropositive, Anti-CCP positive rheumatoide Arthritis (RA) diagnostiziert, inzwischen mit fortgeschrittenen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
title: Anti-CCP-Ak positive paraneoplastische Arthritis bei Plattenepithelkarzinom der Glans penis
Creators: name: Hartig, Ingo
name: Braun, Matthias
name: Munk-Hartig, Anne-Kathrin
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Eine maligne Erkrankung kann mit einer Vielzahl von muskuloskelettalen Symptomen verbunden sein. Dieser Case-report und einzelne Fallberichte deuten darauf hin, dass die Serologie bei der Unterscheidung zwischen entzündlich-rheumatischer Arthritis und paraneoplastischer Arthritis nicht[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
title: Das Rätsel einer Nase
Creators: name: Huber, Melanie
name: Tarner, Ingo H.
name: Müller-Ladner, Ulf
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Ein 31-jähriger Patient stellt sich zur rheumatologischen Diagnostik bei neu aufgetretenen Nasenschleimhautulcerationen und blutiger Rhinitis vor. Seit drei Monaten beklagt er eine vermehrte Borkenbildung. Die Nasenscheidewand sei beim Nießen vor zwei Jahren perforiert. Desweiteren bestünden[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
The Effects of Radiative Feedback and Supernova Induced Turbulence on Early Galaxies
Creators: name: Sarmento, Richard
name: Scannapieco, Evan
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The recently launched James Webb Space Telescope promises unparalleled advances in our understanding of the first stars and galaxies, but realizing this potential requires cosmological simulations that capture the key physical processes that affected these objects. Here we show that radiative transfer and subgrid turbulent mixing are two such processes. By comparing simulations with and without radiative transfer but with exactly the same physical parameters and subgrid turbulent mixing model, we show that tracking radiative transfer suppresses the Population III (Pop III) star formation density by a factor of approximately 4. In both simulations, $\gtrsim 90\%$ of Pop III stars are found in the unresolved pristine regions tracked by our subgrid model, which does a better job at modeling the regions surrounding proto-galaxy cores where metals from supernovae take tens of Myrs to mix thoroughly. At the same time, radiative transfer suppresses Pop III star formation, via the development of ionized bubbles that slows gas accretion in these regions, and it results in compact high-redshift galaxies that are surrounded by isolated low mass satellites. Thus turbulent mixing and radiative transfer are both essential processes that must be included to accurately model the morphology, composition, and growth of primordial galaxies.
description: Accepted by ApJ, Jul 2022, Comments welcome
Whole blood transcriptome characterization of young female triathlon athletes following an endurance exercise: A pilot study
Creators: name: Dr. Bacsi, Attila
name: Penyige, András
name: Becs, Gergely
name: Benkő, Szilvia
name: Kovács, Elek Gergő
name: Jenei, Csaba
name: Pócsi, István
name: Balla, József
name: Csernoch, László
name: Balatoni, Ildikó
Publisher: name: figshare
Year: 2022
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 60405 Gene Expression (incl. Microarray and other genome-wide approaches)

description: Supplemantary Table S1 Effects of endurance exercise on cardiac structural, systolic, and diastolic function parameters were evaluated by echocardiography.
 Supplementary Table S2 The endurance exercise had no significant effect on the tested serum and urine parameters Routine laboratory parameters in serum and urine samples were measured at the Department of Laboratory Medicine, University of Debrecen.
 Supplementary Table S3 In order to assess the effect of endurance exercise on gene expression pattern, total RNA samples were isolated from peripheral blood samples of each participant at five different time points. RNA sequencing was used to identify the presence and determine the quantity of RNA transcripts in the samples. In our RNA-Seq data 10891 transcripts were identified in the five separate sets of samples, out of them 2795 showed significantly different expression in at least one pairwise comparison of the five different sample acquisition time points based on their ANOVA P<0.05 values. Finally, 1855 transcripts were annotated to unique Ensemble IDs, and this gene list was used for further analysis.
UbSRD: The Ubiquitin Structural Relational Database
Creators: name: Jacobs, Tim M.
name: Harrison, Joseph S.
name: Van Doorslaer, Koenraad
name: Houlihan, Kevin
name: Kuhlman, Brian
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: The structurally defined ubiquitin-like homology fold (UBL) can engage in several unique protein–protein interactions and many of these complexes have been characterized with high-resolution techniques. Using Rosetta's structural classification tools, we have created the Ubiquitin Structural Relational Database (UbSRD), an SQL database of features for all 509 UBL-containing structures in the PDB, allowing users to browse these structures by protein–protein interaction and providing a platform for quantitative analysis of structural features. We used UbSRD to define the recognition features of ubiquitin (UBQ) and SUMO observed in the PDB and the orientation of the UBQ tail while interacting with certain types of proteins. While some of the interaction surfaces on UBQ and SUMO overlap, each molecule has distinct features that aid in molecular discrimination. Additionally, we find that the UBQ tail is malleable and can adopt a variety of conformations upon binding. UbSRD is accessible as an online resource at rosettadesign.med.unc.edu/ubsrd.
Experimental study of forces on freely moving spherical particles during resuspension into turbulent flow
Creators: name: Traugott, Hadar
name: Liberzon, Alex
Publisher: name: arXiv
Year: 2015
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: Turbulent resuspension, a process of lifting solid particles from the bottom by turbulent flow, is ubiquitous in environmental and industrial applications. The process is a sequence of events that start with an incipient motion of the particle being dislodged from its place, continue as sliding or rolling on the surface, ending with the particle being detached from the surface and lifted up into the flow. In this study the focus is on the resuspension of solid spherical particles with the density comparable to that of the fluid and the diameter comparable with the Kolmogorov length scale. We track their motion during the lift-off events in an oscillating grid turbulent flow. We measure simultaneously the Lagrangian trajectories of both the particles freely moving along the bottom smooth wall and the surrounding flow tracers. Different force terms acting on particles were estimated based on particle motion and local flow parameters. The results show that: \emph{i}) the lift force is dominant; \emph{ii}) drag force on freely moving particles is less relevant in this type of resuspension; \emph{iii}) the Basset (history or viscous-unsteady) force is a non-negligible component and plays an important role before the lift-off event. Although we cannot estimate very accurately the magnitude of the force terms, we find that during the resuspension they are within the range of $2\div10$ times the buoyancy force magnitude. The findings cannot be extrapolated to particles, which are much smaller than the Kolmogorov length scale, or much denser than the fluid. Nevertheless, the present findings can assist in modeling of the sediment transport, particle filtration, pneumatic conveying and mixing in bio-reactors.
Approximation of Optimal Control Surfaces for $2\times 2$ Skew-Symmetric Evolutionary Game Dynamics
Creators: name: Nicolosi, Gabriel
name: Friesz, Terry
name: Griffin, Christopher
Publisher: name: arXiv
Year: 2022
Subjects: subject: Optimization and Control (math.OC)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: In this paper we study the problem of approximating the general solution to an optimal control problem whose dynamics arise from a $2\times 2$ skew-symmetric evolutionary game with arbitrary initial condition. Our approach uses a Fourier approximation method and generalizes prior work in the use of orthogonal function approximation for optimal control. At the same time we cast the fitting problem in the context of a non-standard feedforward neural network and derive the back-propagation operator in this context. An example of the efficacy of this approach is provided and generalizations are discussed.
description: 17 pages, 5 figures
The Wigner-Yanase information can increase under phase sensitive incoherent operations
Creators: name: Du, Shuanping
name: Bai, Zhaofang
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We found that the Wigner-Yanase skew information, which has been recently proposed as a measure of coherence in [Phys. Rev. Lett. \textbf{113}, 170401(2014)], can increase under a class of operations which may be interpreted as incoherent following the framework of Baumgratz et al., while being phase sensitive.
An ALMA 1.3 millimeter Search for Debris Disks around Solar-type Stars in the Pleiades
Creators: name: Sullivan, Devin
name: Wilner, David
name: Matra, Luca
name: Wyatt, Mark C.
name: Andrews, Sean M.
name: MacGregor, Meredith A.
name: Matthews, Brenda
Publisher: name: arXiv
Year: 2022
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Millimeter emission from debris disks around stars of different ages provides constraints on the collisional evolution of planetesimals. We present ALMA 1.3 millimeter observations of a sample of 76 Solar-type stars in the ~115 Myr old Pleiades star cluster. These ALMA observations complement previous infrared observations of this sample by providing sensitivity to emission from circumstellar dust at lower temperatures, corresponding to debris at radii comparable to the Kuiper Belt and beyond. The observations obtain a beam size of 1.5 arcsec (200 au) and a median rms noise of 54 mircoJy/beam, which corresponds to a fractional luminosity $L_{dust}/L_{star} \sim 10^{-4}$ for 40 K dust for a typical star in the sample. The ALMA images show no significant detections of the targeted stars. We interpret these limits in the context of a steady-state collisional cascade model for debris disk evolution that provides a good description of observations of the field population near the Sun but is not well-calibrated on younger populations.The ALMA non-detections of the Pleiades systems are compatible with the disk flux predictions of this model. We find no high fractional luminosity outliers from these ALMA data that could be associated with enhanced collisions resulting from activity not accounted for by steady-state evolution. However, we note that two systems (HII 1132 and HD 22680) show 24 micron excess much higher than the predictions of this model, perhaps due to unusually high dust production from dynamical events involving planets.
description: 17 pages, 6 figures, accepted for publication in AJ
MuRF1 mono-ubiquitinates TRα to inhibit T3-induced cardiac hypertrophy in vivo
Creators: name: Tang, Wei
name: Berthiaume, Jessica M.
name: Wadosky, Kristine M.
name: Gerdes, A. Martin
name: Willis, Monte S.
name: Portman, Michael A.
name: Zungu, Makhosi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Thyroid hormone (TH) is recognized for its role in cellular metabolism and growth and participates in homeostasis of the heart. T3 activates pro-survival pathways including Akt and mTOR. Treatment with T3 after myocardial infarction is cardioprotective and promotes elements of physiological hypertrophic response after cardiac injury. Although T3 is known to benefit the heart, very little about its regulation at the molecular level has been described to date. The ubiquitin proteasome system (UPS) regulates nuclear hormone receptors such as estrogen, progesterone, androgen, and glucocorticoid receptors by both degradatory and non-degradatory mechanisms. However, how the UPS regulates T3-mediated activity is not well understood. In this study, we aim to determine the role of the muscle-specific ubiquitin ligase muscle ring finger-1 (MuRF1) in regulating T3-induced cardiomyocyte growth. An increase in MuRF1 expression inhibits T3-induced physiological cardiac hypertrophy, whereas a decrease in MuRF1 expression enhances T3’s activity both in vitro and in cardiomyocytes in vivo. MuRF1 interacts directly with TRα to inhibit its activity by posttranslational ubiquitination in a non-canonical manner. We then demonstrated that a nuclear localization apparatus that regulates/inhibits nuclear receptors by sequestering them within a subcompartment of the nucleus was necessary for MuRF1 to inhibit T3 activity. This work implicates a novel mechanism that enhances the beneficial T3 activity specifically within the heart, thereby offering a potential target to enhance cardiac T3 activity in an organ-specific manner.
Oxalis paludosa Saint-Hilaire 1825
Creators: name: López, Alicia
name: Sassone, Agostina B.
name: Fiaschi, Pedro
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Oxalidales
Oxalidaceae
Oxalis
Oxalis paludosa

description: Oxalis paludosa Saint-Hilaire (1825: 121)
 Type:— BRAZIL. Rio Grande do Sul, marais prés le ruisseau Grapuita, 1816-1821,  Saint Hilaire C 2 2580  (lectotype P!, first-step designated by Lourteig [2000: 388]; second-step P-02440278! designated here, image available at http://plants.jstor.org/stable/viewer/10.5555/ al.ap.specimen.p02440278; isolectotypes: P-02440279!, P-02440280!).
 Note:—In the protologue, Saint Hilaire (1825: 121) wrote: “Inveni in pascuis paludosis desertorum provinciae Rio Grande do Sul prope rivulum Garapuità, haud longe a littoribus fluminis Uruguay. Januario florebat”. Lourteig (2000: 388) effected an inadvertent lectotypification but did not discriminate among the three specimens of  Saint Hilaire C 2 2580  at P. The lectotype selected here (P-02440278) is the most complete specimen, perfectly fits the original description and bears two labels annotated by the describing author.
description: Published as part of López, Alicia, Sassone, Agostina B. & Fiaschi, Pedro, 2018, Lectotypifications in Oxalis (Oxalidaceae) for the Flora of Argentina, pp. 189-193 in Phytotaxa 343 (2) on page 192, DOI: 10.11646/phytotaxa.343.2.10, http://zenodo.org/record/13718605
Band splitting induced Berry flux and intrinsic anomalous Hall conductivity in NiCoMnGa quaternary Heusler compound
Creators: name: Shukla, Gaurav K.
name: Sau, Jyotirmay
name: Kumar, Vishal
name: Kumar, Manoranjan
name: Singh, Sanjay
Publisher: name: arXiv
Year: 2022
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The anomalous transport properties of Heusler compounds become a hotspot of research in recent years due to their unique band structure and possible application in spintronics. In this paper, we report the anomalous Hall effect in polycrystalline NiCoMnGa quaternary Heusler compound by experimental means and theoretical calculations. The experimental anomalous Hall conductivity (AHC) was found at about 256 S/cm at 10K with an intrinsic contribution of ~ 121 S/cm. The analysis of Hall data reveals the presence of both extrinsic and intrinsic contributions in AHE. Our theoretical calculations show that a pair of spin-orbit coupled band formed by the band splitting due to spin-orbit interaction (SOI) at the Fermi level produces a finite Berry flux in the system that provides the intrinsic AHC about 100 S/cm, which is in good agreement with the experiment.
Gamma-ray emission from primordial black hole-neutron star interaction
Creators: name: del Barco, Oscar
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The interaction of an asteroid-mass primordial black hole (PBH) with a slowly-rotating neutron star (NS) can lead to detectable gamma-ray emission via modern observatories like Fermi-LAT or e-ASTROGRAM. Depending on the specific PBH relativistic orbit in the NS Schwarschild spacetime and the relative orientation of this binary system with respect to Earth, the PBH Hawking radiation will show a characteristic temperature profile over time. Essentially, a moderate heating behaviour (or even a progressive and constant cooling phase) is found for the majority of the event, followed by a sudden and dramatic cool-down at the end of the burst. Our theoretical model might provide a means of identification of such hypothetical PBH-NS interactions, based on the distinctive temperature evolution of thermal-like gamma ray bursts (GRBs) described in this article.
description: Accepted for publication in Monthly Notices of the Royal Astronomical Society
Recording the Excavations in Troy, 1855–2010
Creators: name: Pavel, Cătălin
Publisher: name: Universität Tübingen
Year: 2019
Subjects: subject: Archäologie , Forschungsgeschichte , Troja , Türkei
subject: 930
subject: archaeology
subject: history of research
subject: Troy
subject: Turkey

description: This article emerges out of a discussion within the team in Troy in response to recent developments in the practice and theory of recording archaeological excavations, as well as in the technology that makes them possible. Methodological awareness must be fostered by analytical concerns and its results offered for public scrutiny; any recording system is thus re-cast as the encapsulation of this methodological awareness. Before thoroughly modernizing the way the excavations are recorded in Troy, a review of how this has been done over the past century and a half is in order. The article consists of two parts. The first presents the way excavations in Troy have been recorded in against the controlled destruction, to highlight the interplay between description and interpretation in the process of recording.
description: Vorliegender Artikel entspringt einer innerhalb des Troia-Projekts hinsichtlich der aktuellen Entwicklungen in den Themenbereich Theorie, Methode und praktische Anwendung neuer Dokumentationssysteme im Rahmen archäologischer Ausgrabungen geführten Diskussion. Methodisches Bewußtsein sollte analytischen Belangen gerecht werden und die erzielten Ergebnisse objektiv überprüfbar sein; in jedem Dokumentationssystem spiegelt sich daher der Umfang der Bereitschaft zur Umsetzung bestimmter methodischer Belange wider. Vor einer Modernisierung der gegenwärtig in Troia angewandten Grabungs- und Dokumentationsverfahren scheint eine Revision der verschiedenen, seit rund 150 Jahren üblichen Systeme angebracht. Der Artikel besteht aus zwei Teilen; im ersten werden die in Troia geläufigen Aufnahmeverfahren vor dem Hintergrund der aktuellen Methodendiskussion in Europa und Nordamerika besprochen. Im zweiten Teil werden diese im Rahmen verschiedener hermeneutischer und epistemologischer Ansätze untersucht, die archäologische Ausgrabungen als »kontrollierte Zerstörung« betrachten, um so die Wechselwirkung zwischen Beschreibung und Interpretation während des Aufnahmeprozesses aufzuzeigen.
Supervised Collective Classification for Crowdsourcing
Creators: name: Chen, Pin-Yu
name: Lien, Chia-Wei
name: Chu, Fu-Jen
name: Ting, Pai-Shun
name: Cheng, Shin-Ming
Publisher: name: arXiv
Year: 2015
Subjects: subject: Social and Information Networks (cs.SI)
subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: Crowdsourcing utilizes the wisdom of crowds for collective classification via information (e.g., labels of an item) provided by labelers. Current crowdsourcing algorithms are mainly unsupervised methods that are unaware of the quality of crowdsourced data. In this paper, we propose a supervised collective classification algorithm that aims to identify reliable labelers from the training data (e.g., items with known labels). The reliability (i.e., weighting factor) of each labeler is determined via a saddle point algorithm. The results on several crowdsourced data show that supervised methods can achieve better classification accuracy than unsupervised methods, and our proposed method outperforms other algorithms.
description: to appear in IEEE Global Communications Conference (GLOBECOM) Workshop on Networking and Collaboration Issues for the Internet of Everything
RAP1-GTPase signaling and platelet function
Creators: name: Stefanini, Lucia
name: Bergmeier, Wolfgang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Platelets are critical for hemostasis, i.e. the body's ability to prevent blood loss at sites of vascular injury. They patrol the vasculature in a quiescent, non-adhesive state for approximately 10 days, after which they are removed from circulation by phagocytic cells of the reticulo-endothelial system. At sites of vascular injury, they promptly shift to an activated, adhesive state required for the formation of a hemostatic plug. The small GTPase RAP1 is a critical regulator of platelet adhesiveness. Our recent studies demonstrate that the antagonistic balance between the RAP1 regulators, CalDAG-GEFI and RASA3, is critical for the modulation of platelet adhesiveness, both in circulation and at sites of vascular injury. The RAP1 activator CalDAG-GEFI responds to small changes in the cytoplasmic calcium concentration and thus provides sensitivity and speed to the activation response, essential for efficient platelet adhesion under conditions of hemodynamic shear stress. The RAP1 inhibitor RASA3 ensures that circulating platelets remain quiescent by restraining CalDAG-GEFI-dependent RAP1 activation. Upon cellular stimulation, it is turned off by P2Y12 signaling to enable sustained RAP1 activation, required for the formation of a stable hemostatic plug. This review will summarize important studies that elucidated the signaling pathways that control RAP1 activation in platelets.
On the Effects of Planetary Oblateness on Exoplanet Studies
Creators: name: Berardo, David
name: DeWit, Julien
Publisher: name: arXiv
Year: 2022
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: When studying transiting exoplanets it is common to assume a spherical planet shape. However short rotational periods can cause a planet to bulge at its equator, as is the case with Saturn whose equatorial radius is almost 10% larger than its polar radius. As a new generation of instruments comes online, it is important to continually assess the underlying assumptions of models to ensure robust and accurate inferences. We analyze bulk samples of known transiting planets and calculate their expected signal strength if they were to be oblate. We find that for noise levels below 100ppm, as many as 100 planets could have detectable oblateness. We also investigate the effects of fitting spherical planet models to synthetic oblate lightcurves. We find that this biases the retrieved parameters by several standard deviations for oblateness values > 0.1-0.2. When attempting to fit an oblateness model to both spherical and oblate lightcurves, we find that the sensitivity of such fits is correlated with both the SNR as well as the time sampling of the data, which can mask the oblateness signal. For typical values of these quantities for Kepler observations, it is difficult to rule out oblateness values less than ~0.25. This results in an accuracy wall of 10-15% for the density of planets which may be oblate. Finally, we find that a precessing oblate planet has the ability to mimic the signature of a long-period companion via transit timing variations, inducing offsets at the level of 10s of seconds.
description: 18 pages, 11 figures, Accepted for publication in the Astrophysical Journal
Diplazium yinchanianum Zi Y. Liu, H. J. Wei & Y. H. Yan 2018, sp. nov.
Creators: name: Liu, Zi-Yue
name: Wei, Hong-Jin
name: Shang, Hui
name: Wei, Ran
name: Wang, Ying
name: Liu, Bao-Dong
name: Yan, Yue- Hong
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Polypodiales
Athyriaceae
Diplazium
Diplazium yinchanianum

description: Diplazium yinchanianum Zi Y. Liu, H. J. Wei & Y. H. Yan, sp. nov. Figs. 3, 4.
 Type:— CHINA. Guangxi Zhuang Autonomous Region: Fangcheng County, Dongzhong Town, Shiwandashan mountains, 21° 39′ 05″ N, 107° 29′ 45″ E, alt. 580 m, 24 Apr. 2014, Y. H. Yan, H. J. Wei & Y. Wang 13341 (holotype CSH-0065059!; isotypes CSH-0065051!, CSH-0065052!, CSH-0065053!, CSH-0065054!, CSH-0065060!).
 Diplazium yinchanianum is morphologically most similar to D. yaoshanense in having slender creeping rhizomes, abrupt laminae apices, and linear sori, but differs from the latter in having oblong lamina that has an apical pinna similar to lateral pinnae (vs. deltoid-lanceolate lamina with pinnatifid apex distinct from lateral pinnae). The phylogenetic analysis showed that they are not conspecific. Instead, D. yinchanianum was resolved as closely related to D. virescens. However, D. virescens is distinctive as it has bipinnate-pinnatifid laminae, linear-lanceolate scales with toothed margins and the toothed scales appear to be different from the distally toothed scales of D. yaoshanense (Fig. 5). Diplazium virescens has reniform or subreniform spores and the perispores are aculeate with massive folds, while D. yaoshanense has subreniform spores and the perispores are hyaline and widely rugate. In contrast, D. yinchanianum has subreniform spores and the perispores are broadly flake-like (Fig. 6; Chang et al. 2001; He & Kato 2013). These species can be identified with the key provided below.
description: Published as part of Liu, Zi-Yue, Wei, Hong-Jin, Shang, Hui, Wei, Ran, Wang, Ying, Liu, Bao-Dong & Yan, Yue- Hong, 2018, Diplazium yinchanianum (Athyriaceae): A New Fern from the Border between China and Vietnam, pp. 139-148 in Phytotaxa 343 (2) on pages 143-144, DOI: 10.11646/phytotaxa.343.2.4, http://zenodo.org/record/13718626