cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
(1303) John Ellis
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Commune girls - Growing up in Utopia?: Women reflecting back on childhoods in British intentional communities 1970-1985
Creators: name: Rhoades, Lucy
Publisher: name: Goldsmiths, University of London
Year: 2009

description: This research is underpinned by my own autobiographical process of reflection on how the culture, ideals and practices of the intentional community I lived in as a child influenced my world-view and way of 'inhabiting' my self, my life, and my relationships with others. The research uses themes of relationship and identity to patch together the memories, recollections, impressions and current ways of 'making sense' of the author and a group of 13 women of my generation (aged between 25-40) who also lived in intentional communities (communes) as children in this time frame. The research focuses on how participants and I have navigated our life narratives; childhood and family, relationships and identities, conceptual and social spaces and if/how this relates back to the experience and practices of time spent as children in the counter culture and in communes in the UK in the 1970s and early 1980s. Of particular interest to me was how participants recall they were thought about and treated as children in the purportedly egalitarian and resistant spaces of communes, their impressions of how family and relationship was thought and practiced there, how it has been for participants to cross over into more mainstream spaces and lifestyles, and how participants feel they have been shaped and affected by their childhood experiences of community. Seeing all identity as embedded in relational as well as conceptual and structural 'webs', the research seeks to explore if and how women who spent time in communes as children have witnessed/lived communes as 'new family forms.' The work enquires about the ways of conducting intimate relationship present in these spaces and how participants have responded to the vision and practices of the communes movement. The research takes particular interest in issues of power and relationship, and keeps an eye open for resistance to both hegemonic mainstream and powerful 'counter-cultural' notions of 'how to live one's life.' It explores the perceived benefits and boons, hurts and harms that participants feel their unusual experience gave them. The research asks how participants have rejected or embraced their childhood experiences at their current age and stage.
Figure S7 from Convergent evolution in Arabidopsis halleri and Arabidopsis arenosa on calamine metalliferous soils
Creators: name: Preite, Veronica
name: Sailer, Christian
name: Syllwasschy, Lara
name: Bray, Sian
name: Ahmadi, Hassan
name: Krämer, Ute
name: Yant, Levi
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Plant Biology
subject: 60408 Genomics

description: It is a plausible hypothesis that parallel adaptation events to the same environmental challenge should result in genetic changes of similar or identical effects, depending on the underlying fitness landscapes. However, systematic testing of this is scarce. Here we examine this hypothesis in two closely related plant species, Arabidopsis halleri and Arabidopsis arenosa, which co-occur at two calamine metalliferous sites harbouring toxic levels of the heavy metals zinc and cadmium. We conduct individual genome resequencing alongside soil elemental analysis for 64 plants from eight populations on metalliferous and non-metalliferous soils, and identify genomic footprints of selection and local adaptation. Selective sweep and environmental association analyses indicate a modest degree of gene as well as functional network convergence, whereby the proximal molecular factors mediating this convergence mostly differ between site pairs and species. Notably, we observe repeated selection on identical SNPs in several A. halleri genes at two independently colonized metalliferous sites. Our data suggest that species-specific metal handling and other biological features could explain a low degree of convergence between species. The parallel establishment of plant populations on calamine metalliferous soils involves convergent evolution, which will likely be more pervasive across sites purposely chosen for maximal similarity in soil composition.This article is part of the theme issue ‘Convergent evolution in the genomics era: new insights and directions’.
Figure S5 from Convergent evolution in Arabidopsis halleri and Arabidopsis arenosa on calamine metalliferous soils
Creators: name: Preite, Veronica
name: Sailer, Christian
name: Syllwasschy, Lara
name: Bray, Sian
name: Ahmadi, Hassan
name: Krämer, Ute
name: Yant, Levi
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Plant Biology
subject: 60408 Genomics

description: It is a plausible hypothesis that parallel adaptation events to the same environmental challenge should result in genetic changes of similar or identical effects, depending on the underlying fitness landscapes. However, systematic testing of this is scarce. Here we examine this hypothesis in two closely related plant species, Arabidopsis halleri and Arabidopsis arenosa, which co-occur at two calamine metalliferous sites harbouring toxic levels of the heavy metals zinc and cadmium. We conduct individual genome resequencing alongside soil elemental analysis for 64 plants from eight populations on metalliferous and non-metalliferous soils, and identify genomic footprints of selection and local adaptation. Selective sweep and environmental association analyses indicate a modest degree of gene as well as functional network convergence, whereby the proximal molecular factors mediating this convergence mostly differ between site pairs and species. Notably, we observe repeated selection on identical SNPs in several A. halleri genes at two independently colonized metalliferous sites. Our data suggest that species-specific metal handling and other biological features could explain a low degree of convergence between species. The parallel establishment of plant populations on calamine metalliferous soils involves convergent evolution, which will likely be more pervasive across sites purposely chosen for maximal similarity in soil composition.This article is part of the theme issue ‘Convergent evolution in the genomics era: new insights and directions’.
Neural Cell Adhesion Molecule-Secreting Transgenic Mice Display Abnormalities in GABAergic Interneurons and Alterations in Behavior
Creators: name: Rodriguiz, Ramona M.
name: Demyanenko, Galina P.
name: Gilmore, Kelly L.
name: Huang, Josh Z.
name: Maness, Patricia F.
name: Panicker, Anitha K.
name: Wetsel, William C.
name: Pillai-Nair, Neeta
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: The extracellular region of the transmembrane neural cell adhesion molecule (NCAM-EC) is shed as a soluble fragment at elevated levels in the schizophrenic brain. A novel transgenic mouse line was generated to identify consequences on cortical development and function of expressing soluble NCAM-EC from the neuron-specific enolase promoter in the developing and mature neocortex and hippocampus. NCAM-EC transgenic mice exhibited a striking reduction in synaptic puncta of GABAergic interneurons in the cingulate, frontal association cortex, and amygdala but not hippocampus, as shown by decreased immunolabeling of glutamic acid decarboxylase-65 (GAD65), GAD67, and GABA transporter 1. Interneuron cell density was unaltered in the transgenic mice. Affected subpopulations of interneurons included basket interneurons evident in NCAM-EC transgenic mice intercrossed with a reporter line expressing green fluorescent protein and by parvalbumin staining. In addition, there appeared to be a reduction in excitatory synapses, as revealed by synaptophysin staining and apical dendritic spine density of cortical pyramidal cells. Behavioral analyses demonstrated higher basal locomotor activity of NCAM-EC mice and enhanced responses to amphetamine and (+)-5-methyl-10,11-dihydro-5
(1304) Mary [Ellis]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A fast and explicit algorithm for simulating the dynamics of small dust grains with smoothed particle hydrodynamics
Creators: name: Price, Daniel J.
name: Laibe, Guillaume
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We describe a simple method for simulating the dynamics of small grains in a dusty gas, relevant to micron-sized grains in the interstellar medium and grains of centimetre size and smaller in protoplanetary discs. The method involves solving one extra diffusion equation for the dust fraction in addition to the usual equations of hydrodynamics. This "diffusion approximation for dust" is valid when the dust stopping time is smaller than the computational timestep. We present a numerical implementation using Smoothed Particle Hydrodynamics (SPH) that is conservative, accurate and fast. It does not require any implicit timestepping and can be straightforwardly ported into existing 3D codes.
description: 15 pages, 10 figures, accepted to MNRAS. Code implementation (ndspmhd v2.1) and setup of test problems available at: http://users.monash.edu.au/~dprice/ndspmhd/. v3: sign errors fixed as per erratum to published paper
Figure S4 from Convergent evolution in Arabidopsis halleri and Arabidopsis arenosa on calamine metalliferous soils
Creators: name: Preite, Veronica
name: Sailer, Christian
name: Syllwasschy, Lara
name: Bray, Sian
name: Ahmadi, Hassan
name: Krämer, Ute
name: Yant, Levi
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Plant Biology
subject: 60408 Genomics

description: It is a plausible hypothesis that parallel adaptation events to the same environmental challenge should result in genetic changes of similar or identical effects, depending on the underlying fitness landscapes. However, systematic testing of this is scarce. Here we examine this hypothesis in two closely related plant species, Arabidopsis halleri and Arabidopsis arenosa, which co-occur at two calamine metalliferous sites harbouring toxic levels of the heavy metals zinc and cadmium. We conduct individual genome resequencing alongside soil elemental analysis for 64 plants from eight populations on metalliferous and non-metalliferous soils, and identify genomic footprints of selection and local adaptation. Selective sweep and environmental association analyses indicate a modest degree of gene as well as functional network convergence, whereby the proximal molecular factors mediating this convergence mostly differ between site pairs and species. Notably, we observe repeated selection on identical SNPs in several A. halleri genes at two independently colonized metalliferous sites. Our data suggest that species-specific metal handling and other biological features could explain a low degree of convergence between species. The parallel establishment of plant populations on calamine metalliferous soils involves convergent evolution, which will likely be more pervasive across sites purposely chosen for maximal similarity in soil composition.This article is part of the theme issue ‘Convergent evolution in the genomics era: new insights and directions’.
(1305) John Burras
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Figure S2 from Convergent evolution in Arabidopsis halleri and Arabidopsis arenosa on calamine metalliferous soils.
Creators: name: Preite, Veronica
name: Sailer, Christian
name: Syllwasschy, Lara
name: Bray, Sian
name: Ahmadi, Hassan
name: Krämer, Ute
name: Yant, Levi
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Plant Biology
subject: 60408 Genomics

description: It is a plausible hypothesis that parallel adaptation events to the same environmental challenge should result in genetic changes of similar or identical effects, depending on the underlying fitness landscapes. However, systematic testing of this is scarce. Here we examine this hypothesis in two closely related plant species, Arabidopsis halleri and Arabidopsis arenosa, which co-occur at two calamine metalliferous (M) sites harbouring toxic levels of the heavy metals zinc and cadmium. We conduct individual genome resequencing alongside soil elemental analysis for 64 plants from eight populations on M and non-metalliferous (NM) soils, and identify genomic footprints of selection and local adaptation. Selective sweep and environmental association analyses indicate a modest degree of gene as well as functional network convergence, whereby the proximal molecular factors mediating this convergence mostly differ between site pairs and species. Notably, we observe repeated selection on identical single nucleotide poly-morphisms in several A. halleri genes at two independently colonized M sites. Our data suggest that species-specific metal handling and other biological features could explain a low degree of convergence between species. The parallel establishment of plant populations on calamine M soils involves convergent evolution, which will probably be more pervasive across sites purposely chosen for maximal similarity in soil composition.This article is part of the theme issue ‘Convergent evolution in the genomics era: new insights and directions’.
(1307) Jonathan Pugmire
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Regulation of Dendritic Spine Morphogenesis by Insulin Receptor Substrate 53, a Downstream Effector of Rac1 and Cdc42 Small GTPases
Creators: name: Lee, Jae Ran
name: Kim, Seho
name: Kim, Karam
name: Na, Moonseok
name: Lee, Hyun Woo
name: Kim, Eunjoon
name: Choi, Jeonghoon
name: Burette, Alain
name: Weinberg, Richard J.
name: Ko, Jaewon
name: Racz, Bence
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: The small GTPases Rac1 and Cdc42 are key regulators of the morphogenesis of actin-rich dendritic spines in neurons. However, little is known about how activated Rac1/Cdc42 regulates dendritic spines. Insulin receptor substrate 53 (IRSp53), which is highly expressed in the postsynaptic density (PSD), is known to link activated Rac1/Cdc42 to downstream effectors for actin regulation in non-neural cells. Here, we report that IRSp53 interacts with two specific members of the PSD-95 family, PSD-95 and chapsyn-110/PSD-93, in brain. An IRSp53 mutant lacking the C-terminal PSD-95-binding motif shows significant loss of synaptic localization in cultured neurons. Overexpression of IRSp53 in cultured neurons increases the density of dendritic spines but does not affect their length or width. Conversely, short-interfering RNA-mediated knock-down of IRSp53 reduces the density, length, and width of spines. In addition, the density and size of spines are decreased by a dominant-negative IRSp53 with a point mutation in the Src homology 3 (SH3) domain and a dominant-negative proline-rich region of WAVE2 (Wiskott-Aldrich syndrome protein family Verprolin-homologous protein), a downstream effector of IRSp53 that binds to the SH3 domain of IRSp53. These results suggest that PSD-95 interaction is an important determinant of synaptic IRSp53 localization and that the SH3 domain of IRSp53 links activated Rac1/Cdc42 to downstream effectors for the regulation of spine morphogenesis.
Competitive co-adsorption of CO2 with H2O, NH3, SO2, NO, NO2, N2, O2, and CH4 in M-MOF-74 (M= Mg, Co, Ni): the role of hydrogen bonding
Creators: name: Tan, Kui
name: Zuluaga, Sebastian
name: Gong, Qihan
name: Gao, Yuzhi
name: Nijem, Nour
name: Li, Jing
name: Thonhauser, Timo
name: Chabal, Yves J
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The importance of co-adsorption for applications of porous materials in gas separation has motivated fundamental studies, which have initially focused on the comparison of the binding energies of different gas molecules in the pores (i.e. energetics) and their overall transport. By examining the competitive co-adsorption of several small molecules in M-MOF-74 (M= Mg, Co, Ni) with in-situ infrared spectroscopy and ab initio simulations, we find that the binding energy at the most favorable (metal) site is not a sufficient indicator for prediction of molecular adsorption and stability in MOFs. Instead, the occupation of the open metal sites is governed by kinetics, whereby the interaction of the guest molecules with the MOF organic linkers controls the reaction barrier for molecular exchange. Specifically, the displacement of CO2 adsorbed at the metal center by other molecules such as H2O, NH3, SO2, NO, NO2, N2, O2, and CH4 is mainly observed for H2O and NH3, even though SO2, NO, and NO2, have higher binding energies (~70-90 kJ/mol) to metal sites than that of CO2 (38 to 48 kJ/mol) and slightly higher than water (~60-80 kJ/mol). DFT simulations evaluate the barriers for H2O->CO2 and SO2->CO2 exchange to be - 13 and 20 kJ/mol, respectively, explaining the slow exchange of CO2 by SO2, compared to water. Furthermore, the calculations reveal that the kinetic barrier for this exchange is determined by the specifics of the interaction of the second guest molecule (e.g., H2O or SO2) with the MOF ligands.
Figure S3 from Convergent evolution in Arabidopsis halleri and Arabidopsis arenosa on calamine metalliferous soils.
Creators: name: Preite, Veronica
name: Sailer, Christian
name: Syllwasschy, Lara
name: Bray, Sian
name: Ahmadi, Hassan
name: Krämer, Ute
name: Yant, Levi
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Plant Biology
subject: 60408 Genomics

description: It is a plausible hypothesis that parallel adaptation events to the same environmental challenge should result in genetic changes of similar or identical effects, depending on the underlying fitness landscapes. However, systematic testing of this is scarce. Here we examine this hypothesis in two closely related plant species, Arabidopsis halleri and Arabidopsis arenosa, which co-occur at two calamine metalliferous (M) sites harbouring toxic levels of the heavy metals zinc and cadmium. We conduct individual genome resequencing alongside soil elemental analysis for 64 plants from eight populations on M and non-metalliferous (NM) soils, and identify genomic footprints of selection and local adaptation. Selective sweep and environmental association analyses indicate a modest degree of gene as well as functional network convergence, whereby the proximal molecular factors mediating this convergence mostly differ between site pairs and species. Notably, we observe repeated selection on identical single nucleotide poly-morphisms in several A. halleri genes at two independently colonized M sites. Our data suggest that species-specific metal handling and other biological features could explain a low degree of convergence between species. The parallel establishment of plant populations on calamine M soils involves convergent evolution, which will probably be more pervasive across sites purposely chosen for maximal similarity in soil composition.This article is part of the theme issue ‘Convergent evolution in the genomics era: new insights and directions’.
Retinoic Acid Signaling Identifies a Distinct Precursor Population in the Developing and Adult Forebrain
Creators: name: LaMantia, Anthony Samuel
name: Haskell, Gloria Thompson
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: We asked whether retinoic acid (RA), an established transcriptional regulator in regenerating and developing tissues, acts directly on distinct cell classes in the mature or embryonic forebrain. We identified a subset of slowly dividing precursors in the adult subventricular zone (SVZ) that is transcriptionally activated by RA. Most of these cells express glial fibrillary acidic protein, a smaller subset expresses the epidermal growth factor receptor, a few are terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end labeling positive, and they can be mitotically labeled by sustained rather than acute bromodeoxyuridine exposure. RA activation in similar cells in SVZ-derived neurospheres depends on retinoid synthesis from the premetabolite retinol. The apparent influence of RA on precursors
Circular polarisation of synchrotron radiation in high magnetic fields
Creators: name: de Búrca, Diarmaid
name: Shearer, Andrew
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The general model for incoherent synchrotron radiation has long been known, with the first theory being published by Westfold in $1959$ and continued by Westfold and Legg in $1968$. When this model was first developed it was applied to radiation from Jupiter, with a magnetic field of $\approx$ 1 G. Pulsars have a magnetic field of $\approx 10^{12}$ G. The Westfold and Legg model predict a circular polarization which is proportional to the square root of the magnetic field, and consequently predicts greater than 100 per cent circular polarization at high magnetic fields. Here a new model is derived based upon a more detailed analysis of the pitch angle distribution. This model is concerned with the frequency range $f_{B_0}/γ<
description: 10 pages accepted for publication in MNRAS
(1299) Thomas Burras
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Figure S1 from Convergent evolution in Arabidopsis halleri and Arabidopsis arenosa on calamine metalliferous soils.
Creators: name: Preite, Veronica
name: Sailer, Christian
name: Syllwasschy, Lara
name: Bray, Sian
name: Ahmadi, Hassan
name: Krämer, Ute
name: Yant, Levi
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Plant Biology
subject: 60408 Genomics

description: It is a plausible hypothesis that parallel adaptation events to the same environmental challenge should result in genetic changes of similar or identical effects, depending on the underlying fitness landscapes. However, systematic testing of this is scarce. Here we examine this hypothesis in two closely related plant species, Arabidopsis halleri and Arabidopsis arenosa, which co-occur at two calamine metalliferous (M) sites harbouring toxic levels of the heavy metals zinc and cadmium. We conduct individual genome resequencing alongside soil elemental analysis for 64 plants from eight populations on M and non-metalliferous (NM) soils, and identify genomic footprints of selection and local adaptation. Selective sweep and environmental association analyses indicate a modest degree of gene as well as functional network convergence, whereby the proximal molecular factors mediating this convergence mostly differ between site pairs and species. Notably, we observe repeated selection on identical single nucleotide poly-morphisms in several A. halleri genes at two independently colonized M sites. Our data suggest that species-specific metal handling and other biological features could explain a low degree of convergence between species. The parallel establishment of plant populations on calamine M soils involves convergent evolution, which will probably be more pervasive across sites purposely chosen for maximal similarity in soil composition.This article is part of the theme issue ‘Convergent evolution in the genomics era: new insights and directions’.
Visual Deprivation Modifies Both Presynaptic Glutamate Release and the Composition of Perisynaptic/Extrasynaptic NMDA Receptors in Adult Visual Cortex
Creators: name: Yashiro, Koji
name: Corlew, Rebekah
name: Philpot, Benjamin D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Use-dependent modifications of synapses have been well described in the developing visual cortex, but the ability for experience to modify synapses in the adult visual cortex is poorly understood. We found that 10 d of late-onset visual deprivation modifies both presynaptic and postsynaptic elements at the layer 4-->2/3 connection in the visual cortex of adult mice, and these changes differ from those observed in juveniles. Although visual deprivation in juvenile mice modifies the subunit composition and increases the current duration of synaptic NMDA receptors (NMDARs), no such effect is observed at synapses between layer 4 and layer 2/3 pyramidal neurons in adult mice. Surprisingly, visual deprivation in adult mice enhances the temporal summation of NMDAR-mediated currents induced by bursts of high-frequency stimulation. The enhanced temporal summation of NMDAR-mediated currents in deprived cortex could not be explained by a reduction in the rate of synaptic depression, because our data indicate that late-onset visual deprivation actually increases the rate of synaptic depression. Biochemical and electrophysiological evidence instead suggest that the enhanced temporal summation in adult mice could be accounted for by a change in the molecular composition of NMDARs at perisynaptic/extrasynaptic sites. Our data demonstrate that the experience-dependent modifications observed in the adult visual cortex are different from those observed during development. These differences may help to explain the unique consequences of sensory deprivation on plasticity in the developing versus mature cortex.
Axonal Ensheathment and Septate Junction Formation in the Peripheral Nervous System of Drosophila
Creators: name: Paik, Raehum
name: Banerjee, Swati
name: Pillai, Anilkumar M.
name: Bhat, Manzoor A.
name: Li, Jingjun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Axonal insulation is critical for efficient action potential propagation and normal functioning of the nervous system. In
Data, code, and output related to water lead levels
Creators: name: Dorevitch, Samuel
Publisher: name: Zenodo
Year: 2023
Subjects: water lead
water copper
Illinois
Pennsylvania

description: The purpose of this research was to evaluate the need to repeatedly sample water from homes to identify infrequent, but high "spikes" in water lead levels due to the sporadic release of lead particulates. The Illinois and Pennsylvania data were used in establishing baseline (first round of sampling) water lead levels. The simulations were created using various assumptions of baseline prevalence and various probabilities of spike occurrence on the N+1 round of sampling, given the results on the N round. The findings of the research indicate that household tap water needs to be sampled at least 5–7 times to achieve a 50% probability of identifying hazardous spikes in water lead levels.
description: The Illinois Lead and Copper Rule dataset was downloaded from http://163.191.83.31/dww/index.jsp for 2020 and the first half of 2021. It excludes water samples from source water and from water upstream of home/school sampling points. The Pennsylvania Lead and Copper Rule dataset for 2020 and the first half of 2021 were downloaded from http://www.drinkingwater.state.pa.us/. That dataset includes water samples from source water and water upstream of the home/school sampling points. The code was used to simulate water lead levels in 100,000 homes each sampled 15 times, under a variety of assumptions about baseline distribution of water lead levels and transitional probabilities. The tables are the output of that code.
(1301) Thomas Burwell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Unified Description of Charmonium Suppression in Quark-Gluon Plasma Medium at RHIC and LHC Energies
Creators: name: Singh, Captain R.
name: Srivastava, P. K.
name: Ganesh, S.
name: Mishra, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Recent experimental and theoretical studies suggest that the quarkonia suppression in a thermal QCD medium created at heavy ion collisions is a complex interplay of various physical processes. In this article we put together most of these processes in a unified way to calculate the charmonium survival probability (nuclear modification factor) at energies available at relativistic heavy ion collider (RHIC) and large hadron collider (LHC) experiments. We have included shadowing as the dominant cold nuclear matter (CNM) effect. Further, gluo-dissociation and collision damping has been included which provide width to the spectral function of charmonia in a thermal medium and causes the dissociation of charmonium along with usual colour screening. We include the colour screening using our recently proposed modified Chu and Matsui model. Furthermore we incorporate the recombination of uncorrelated charm and anti-charm quark for the regeneration of charmonium over the entire temporal evolution of QGP medium. Finally we do the feed-down correction from the excited states to calculate the survival probability of charmonium. We find that our unified model suitably describes the experimental nuclear modification data of $J/ψ$ at RHIC and LHC simultaneously.
description: 25 pages, 11 figures, version accepted for publication in Physical Review C
Hybridization of Rydberg electron orbitals by molecule formation
Creators: name: Gaj, A.
name: Krupp, A. T.
name: Ilzhöfer, P.
name: Löw, R.
name: Hofferberth, S.
name: Pfau, T.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: The formation of ultralong-range Rydberg molecules is a result of the attractive interaction between Rydberg electron and polarizable ground state atom in an ultracold gas. In the nondegenerate case the backaction of the polarizable atom on the electronic orbital is minimal. Here we demonstrate, how controlled degeneracy of the respective electronic orbitals maximizes this backaction and leads to stronger binding energies and lower symmetry of the bound dimers. Consequently, the Rydberg orbitals hybridize due to the molecular bond.
Cocaine Increases Dopamine Release by Mobilization of a Synapsin-Dependent Reserve Pool
Creators: name: Venton, B. Jill
name: Phillips, Paul E.M.
name: Gitler, Daniel
name: Augustine, George J.
name: Greengard, Paul
name: Seipel, Andrew T.
name: Wetsel, William C.
name: Wightman, R. Mark
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Cocaine primarily exerts its behavioral effects by enhancing dopaminergic neurotransmission, amplifying dopamine-encoded sensorimotor integration. The presumed mechanism for this effect is inhibition of the dopamine transporter, which blocks dopamine uptake and prolongs the duration of dopamine in the extracellular space. However, there is growing evidence that cocaine can also augment dopamine release. Here, we directly monitored the actions of cocaine on dopamine release by using electrochemical detection to measure extracellular dopamine in the striatum of anesthetized mice. Cocaine enhanced the levels of striatal dopamine produced by electrical stimulation of dopaminergic neurons. Even after pretreatment with alpha-methyl-p-tyrosine, which depletes the readily releasable pool of dopamine, cocaine was still capable of elevating dopamine levels. This suggests that cocaine enhances dopamine release by mobilizing a reserve pool of dopamine-containing synaptic vesicles. To test this hypothesis, we examined electrically evoked dopamine release in synapsin I/II/III triple knock-out mice, which have impaired synaptic vesicle reserve pools. Knock-out of synapsins greatly reduced the ability of cocaine to enhance dopamine release with long stimulus trains or after depletion of the newly synthesized pool. We therefore conclude that cocaine enhances dopamine release and does so by mobilizing a synapsin-dependent reserve pool of dopamine-containing synaptic vesicles. This capacity to enhance exocytotic release of dopamine may be important for the psychostimulant actions of cocaine.
Three-Body Non-Leptonic B Decays and QCD Factorization
Creators: name: Kränkl, Susanne
name: Mannel, Thomas
name: Virto, Javier
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We extend the framework of QCD factorization to non-leptonic $B$ decays into three light mesons, taking as an example the decay $B^+ \to π^+ π^+ π^-$. We discuss the factorization properties of this decay in different regions of phase space. We argue that, in the limit of very large $b$-quark mass, the central region of the Dalitz plot can be described in terms of the $B \to π$ form factor and the $B$ and $π$ light-cone distribution amplitudes. The edges of the Dalitz plot, on the other hand, require different non-perturbative input: the $B \to ππ$ form factor and the two-pion distribution amplitude. We present the set-up for both regions to leading order in both $α_s$ and $Λ_{\rm QCD} / m_b$ and discuss how well the two descriptions merge. We argue that for realistic $B$-meson masses there is no perturbative center in the Dalitz plot, but that a systematic description might be possible in the context of two-pion states. As an example, we estimate the $B\toρπ$ branching fraction beyond the quasi-particle approximation. We also discuss the prospects for studies of three-body and quasi-two-body non-leptonic $B$ decays from QCD.
description: 20 pages, 8 figures. Version published in Nucl.Phys.B
On Exact Solutions and the Consistency of 3D Minimal Massive Gravity
Creators: name: Altas, Emel
name: Tekin, Bayram
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We show that all algebraic Type-O, Type-N and Type-D and some Kundt-Type solutions of Topologically Massive Gravity are inherited by its holographically well-defined deformation, that is the recently found Minimal Massive Gravity. This construction provides a large class of constant scalar curvature solutions to the theory. We also study the consistency of the field equations both in the source-free and matter-coupled cases. Since the field equations of MMG do not come from a Lagrangian that depends on the metric and its derivatives only, it lacks the Bianchi identity valid for all non-singular metrics. But it turns out that for the solutions of the equations, Bianchi identity is satisfied. This is a necessary condition for the consistency of the classical field equations but not a sufficient one, since the the rank-two tensor equations are susceptible to double-divergence. We show that for the source-free case the double-divergence of the field equations vanish for the solutions. In the matter-coupled case, we show that the double-divergence of the left-hand side and the right-hand side are equal to each other for the solutions of the theory. This construction completes the proof of the the consistency of the field equations.
description: 8 pages
(1302) Sarah Ellis
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Microporosity and parent body of the rubble-pile NEA (162173) Ryugu
Creators: name: Neumann, Wladimir
name: Grott, Matthias
name: Trieloff, Mario
name: Jaumann, Ralf
name: Biele, Jens
name: Hamm, Maximilian
name: Kührt, Ekkehard
Publisher: name: arXiv
Year: 2023
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Observations of C-type NEAs and lab investigations of carbonaceous chondritic (CC) meteorites provide strong evidence for a high porosity of C-type asteroids. Boulder microporosity values derived from in-situ measurements at the surface of the rubble-pile NEA Ryugu of up to 55% are substantially higher than for water-rich CC samples and could indicate distinct evolution paths for the parent body of Ryugu and parent bodies of carbonaceous chondrites, despite spectral similarities. In the present study, we calculate the evolution of the temperature and porosity for early solar system's planetesimals in order to constrain the range of parameters that result in microporosities compatible with Ryugu's high-porosity material and likely burial depths for the boulders observed at the surface. By varying key properties of the parent body, such as accretion time t0 and radius R that have strong influence on temperature and porosity and by comparing the interior porosity distribution with the measured boulder microporosity, hydration, and partial dehydration of the material, we constrain a field within the (R,t0)-space appropriate for bodies that are likely to have produced such material. Our calculations indicate a parent body size of only a few km and its early accretion within <~2-3 Myr after the formation of Ca-Al-rich inclusions. A gradual final porosity profile of best-fit bodies indicates production of both low- and high-density boulders from the parent body material. By contrast, parent body properties for CI and CM chondrites obtained by fitting carbonate formation data indicate a radius of ~20-25 km and an accretion time of ~3.75 Myr after CAIs. These results imply a population of km-sized early accreting porous planetesimals as parent bodies of Ryugu (and, potentially, other NEAs) and a population of larger late accreting less porous parent bodies of water-rich carbonaceous chondrites.
Indications of Negative Evolution for the Sources of the Highest Energy Cosmic Rays
Creators: name: Taylor, Andrew M.
name: Ahlers, Markus
name: Hooper, Dan
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Using recent measurements of the spectrum and chemical composition of the highest energy cosmic rays, we consider the sources of these particles. We find that the data strongly prefers models in which the sources of the ultra-high energy cosmic rays inject predominantly intermediate mass nuclei, with comparatively few protons or heavy nuclei, such as iron or silicon. If the number density of sources per comoving volume does not evolve with redshift, the injected spectrum must be very hard ($α\simeq 1$) in order to fit the spectrum observed at Earth. Such a hard spectral index would be surprising and difficult to accommodate theoretically. In contrast, much softer spectral indices, consistent with the predictions of Fermi acceleration ($α\simeq 2$), are favored in models with negative source evolution. With this theoretical bias, these observations thus favor models in which the sources of the highest energy cosmic rays are preferentially located within the low-redshift universe.
description: 9 pages, 4 figures
Figure S2 from Convergent evolution in Arabidopsis halleri and Arabidopsis arenosa on calamine metalliferous soils
Creators: name: Preite, Veronica
name: Sailer, Christian
name: Syllwasschy, Lara
name: Bray, Sian
name: Ahmadi, Hassan
name: Krämer, Ute
name: Yant, Levi
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Plant Biology
subject: 60408 Genomics

description: It is a plausible hypothesis that parallel adaptation events to the same environmental challenge should result in genetic changes of similar or identical effects, depending on the underlying fitness landscapes. However, systematic testing of this is scarce. Here we examine this hypothesis in two closely related plant species, Arabidopsis halleri and Arabidopsis arenosa, which co-occur at two calamine metalliferous sites harbouring toxic levels of the heavy metals zinc and cadmium. We conduct individual genome resequencing alongside soil elemental analysis for 64 plants from eight populations on metalliferous and non-metalliferous soils, and identify genomic footprints of selection and local adaptation. Selective sweep and environmental association analyses indicate a modest degree of gene as well as functional network convergence, whereby the proximal molecular factors mediating this convergence mostly differ between site pairs and species. Notably, we observe repeated selection on identical SNPs in several A. halleri genes at two independently colonized metalliferous sites. Our data suggest that species-specific metal handling and other biological features could explain a low degree of convergence between species. The parallel establishment of plant populations on calamine metalliferous soils involves convergent evolution, which will likely be more pervasive across sites purposely chosen for maximal similarity in soil composition.This article is part of the theme issue ‘Convergent evolution in the genomics era: new insights and directions’.
Deletion of the Ubiquitin Ligase CHIP Leads to the Accumulation, But Not the Aggregation, of Both Endogenous Phospho- and Caspase-3-Cleaved Tau Species
Creators: name: Petrucelli, Leonard
name: Yue, Mei
name: Eckman, Christopher
name: Dunmore, Judith H.
name: Lee, Wing C.
name: Dickson, Dennis W.
name: Zehr, Cynthia
name: Dickey, Chad A.
name: West, Gemma
name: Caldwell, Guy A.
name: Hutton, Michael
name: Lin, Wen Lang
name: Clark, Amber M.K.
name: Cao, Songsong
name: Patterson, Cam
name: Caldwell, Kim A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Accumulation of the microtubule-associated protein tau into neurofibrillary lesions is a pathological consequence of several neurodegenerative diseases, including Parkinson's disease and Alzheimer's disease. Hereditary mutations in the
Oil&Gas impact on water sector based on Save Lake Balkhash International Research
Creators: name: Ussenaliyeva, Aizhan
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 370201
subject: Climate change processes
classificationCode: 370202
subject: Climatology
classificationCode: 380302
subject: Macroeconomic theory
classificationCode: 380304
subject: Microeconomic theory
classificationCode: 410403
subject: Environmental education and extension
classificationCode: 410404
subject: Environmental management
classificationCode: 410406
subject: Natural resource management

description: My analysis on how Oil&Gas impacts the Water sector. Part 1.