cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Viscosity and dissipation - early stages
Creators: name: Bozek, P.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: A very early start up time of the hydrodynamic evolution is needed in order to reproduce observations from relativistic heavy-ion collisions experiments. At such early times the systems is still not locally equilibrated. Another source of deviations from local equilibrium is the viscosity of the fluid. We study these effects at very early times to obtain a dynamical prescription for the transition from an early 2-dimensional expansion to a nearly equilibrated 3-dimensional expansion at latter stages. The role of viscosity at latter stages of the evolution is also illustrated.
description: 6 pages, WPCF 2008
Comment on "Mass and K Lambda coupling of N*(1535)"
Creators: name: Ceci, S.
name: Svarc, A.
name: Zauner, B.
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: It is argued in [1] that when the strong coupling to the K Lambda channel is considered, Breit-Wigner mass of the lightest orbital excitation of the nucleon N(1535) shifts to a lower value. The new value turned out to be smaller than the mass of the lightest radial excitation N(1440), which effectively solved the long-standing problem of conventional constituent quark models. In this Comment we show that it is not the Breit-Wigner mass of N(1535) that is decreased, but its bare mass. [1] B. C. Liu and B. S. Zou, Phys. Rev. Lett. 96, 042002 (2006).
description: 3 pages, comment on "Mass and K Lambda coupling of N*(1535)", B. C. Liu and B. S. Zou, Phys. Rev. Lett. 96, 042002 (2006)
Faddeev-Popov spectra at the Gribov horizon
Creators: name: Greensite, J.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: I present a perturbative calculation of the spectrum of the Faddeev-Popov operator in Coulomb gauge in three dimensions, and Landau gauge in two and three dimensions, with an ansatz for the gluon propagator as the non-perturbative input. The results show how the low-lying Faddeev-Popov eigenvalue spectrum is modified as the first Gribov horizon is approached, and how the spectra can differ in Coulomb and Landau gauges.
description: 12 pages, 8 figures; v2: reference added
Sous le shingle, la plage : Stratégies de transfert des realia dans les traductions françaises d'Alice's Adventures in Wonderland de Lewis Carroll (1869-2009)
Creators: name: Houyaux, Justine
Publisher: name: Zenodo
Year: 2019
Subjects: Translation studies
Traductologie
Realia
Culture
Traduction

description: Poster présenté à l'occasion de la Journée des Doctorants de l'École Doctorale ED3bis du FNRS le 23 mai 2019 à l'ULiège
Limit Theorems for Individual-Based Models in Economics and Finance
Creators: name: Remenik, Daniel
Publisher: name: arXiv
Year: 2008
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60K35, 60B12, 46N30, 62P50, 91B70

description: There is a widespread recent interest in using ideas from statistical physics to model certain types of problems in economics and finance. The main idea is to derive the macroscopic behavior of the market from the random local interactions between agents. Our purpose is to present a general framework that encompasses a broad range of models, by proving a law of large numbers and a central limit theorem for certain interacting particle systems with very general state spaces. To do this we draw inspiration from some work done in mathematical ecology and mathematical physics. The first result is proved for the system seen as a measure-valued process, while to prove the second one we will need to introduce a chain of embeddings of some abstract Banach and Hilbert spaces of test functions and prove that the fluctuations converge to the solution of a certain generalized Gaussian stochastic differential equation taking values in the dual of one of these spaces.
description: To appear in Stochastic Processes and their Applications
Additional file 4 of Mediterranean diet in axial spondyloarthritis: an observational study in an Italian monocentric cohort
Creators: name: Ometto, Francesca
name: Ortolan, Augusta
name: Farber, Davide
name: Lorenzin, Mariagrazia
name: Dellamaria, Giulia
name: Cozzi, Giacomo
name: Favero, Marta
name: Valentini, Romina
name: Doria, Andrea
name: Ramonda, Roberta
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 4. Title: PREDIMED questionnaire questions results in the nutritional group and control group. Description: A figure detailing the answers to each question of the PREDIMED questionnaire in the study.
Structural and functional characterisation of atbor1 and uapa and development of novel tools for membrane protein studies
Creators: name: Cecchetti, Cristina
Publisher: name: Imperial College London
Year: 2021

description: Integral membrane transporters are responsible of the translocation of essential compounds and waste products from one side of the membrane to the other. Boron is an essential micronutrient for plants, critical for cell growth, development and stability. The main focus of the PhD was Arabidopsis thaliana AtBOR1, responsible of active transport of B from root cells to the xylem. A structure of a C-terminally truncated AtBOR1 was solved at a resolution of 4.1 Å, lacking key details essential for understanding the transport mechanism. AtBOR1 WT was expressed, purified and crystallised, yielding crystals diffracting maximally to 7 Å. Mutants AtBOR1-M363F and -M363Y, presented enhanced stability and decreased activity compared to the WT, suggesting a reduction in conformational flexibility. AtBOR1-M363F and -M363Y crystals diffracted on average to a higher resolution than the WT (~5.5 Å). A second project focused on the uric acid-xanthine/H+ symporter of Aspergillus nidulans (UapA). The structure of a non-functional mutant UapA-G411V1-11 was recently solved at 4.2 Å, in the inward facing conformation. Evidence suggested that UapA-Q408E is in the outward facing conformation. UapA-Q408E1-11 was purified to high homogeneity and the crystals diffracted maximally to ~4.5 Å, allowing collection of a partial dataset. The protein was also reconstituted in nanodiscs for negative stain analysis revealing that the sample is monodisperse, forming the basis of possible future work using cryo-EM. The third branch of the PhD focused on the development and characterisation of novel tools for membrane protein studies. AtBOR1 WT was employed to screen six different families of novel amphiphiles, proving to enhance the protein stability in solution. Finally, a novel high-throughput screen to facilitate identification of lipids stabilising membrane protein in detergent-based solution was designed, produced and tested using UapA-G411V1-11 in collaboration with Molecular Dimensions and Anatrace. Upon further optimisation this screen could become a commercially viable product.
Spin-waves in the $J_{1a}-J_{1b}-J_{2}$ orthorombic square-lattice Heisenberg models: Application to the iron pnictide materials
Creators: name: Applegate, R.
name: Oitmaa, J.
name: Singh, R. R. P.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Motivated by the observation of spatially anisotropic exchange constants in the iron pnictide materials, we study the spin-wave spectra of the $J_{1a}-J_{1b}-J_{2}$ Heisenberg models on a square-lattice with nearest neighbor exchange $J_{1a}$ along x and $J_{1b}$ along y axis and a second neighbor exchange $J_2$. We focus on the regime, where the spins order at ($π,0$), and compute the spectra by systematic expansions around the Ising limit. We study both spin-half and spin-one Heisenberg models as well as a range of parameters to cover various cases proposed for the iron pnictide materials. The low-energy spectra have anisotropic spin-wave velocities and are renormalized with respect to linear spin-wave theory by up to 20 percent, depending on parameters. Extreme anisotropy, consisting of a ferromagnetic $J_{1b}=- |J_F|$, is best distinguished from a weak anisotropy ($J_{1a}\approx J_{1b}=J_1$, $J_2>J_1/2$) by the nature of the spin-waves near the wavevectors ($0,π$) or ($π,π$). The reported spectra for the pnictide material CaFe$_2$As$_2$ clearly imply such an extreme anisotropy.
description: 6 pages, 10 figures
Sturm-Schroedinger equations: formula for metric
Creators: name: Znojil, Miloslav
name: Geyer, Hendrik B.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Sturm-Schroedinger equations $Hψ=E Wψ$ with $H\neq H^\dagger$ and $W\neq W^\dagger \neq I$ are considered, with a weak point of the theory lying in the purely numerical matrix-inversion form of the double-series definition of the necessary metric operator $Θ$ in the physical Hilbert space of states [M. Znojil, J. Phys. A: Math. Theor. 41 (2008) 215304]. This shortcoming is removed here via an amended, single-series definition of $Θ$.
description: 14pp
On Unconventional Electron Pairing In a Periodic Potential
Creators: name: Voroshilov, Valentin
Publisher: name: arXiv
Year: 2010
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: On the assumption that two electrons with the same group velocity effectively attract each other a simple model Hamiltonian is proposed to question the existence of unconventional electron pairs formed by electrons in a strong periodic potential.
description: 8 pages
Enhancement of the superconducting transition temperature in cuprate heterostructures
Creators: name: Goren, Lilach
name: Altman, Ehud
Publisher: name: arXiv
Year: 2008
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Is it possible to increase Tc by constructing cuprate heterostructures, which combine the high pairing energy of underdoped layers with the large carrier density of proximate overdoped layers? We investigate this question within a model bilayer system using an effective theory of the doped Mott insulator. Interestingly, the question hinges on the fundamental nature of the superconducting state in the underdoped regime. Within a plain slave boson mean field theory, there is absolutely no enhancement of Tc. However, we do get a substantial enhancement for moderate inter-layer tunneling when we use an effective low energy theory of the bilayer in which the effective quasiparticle charge in the underdoped regime is taken as an independent phenomenological parameter. We study the Tc enhancement as a function of the doping level and the inter-layer tunneling, and discuss possible connections to recent experiments by Yuli et al. [Phys. Rev. Lett. 101, 057005 (2008)]. Finally, we predict a unique paramagnetic reduction of the zero temperature phase stiffness of coupled layers, which depends on the difference in the current carried by quasiparticles on the two types of layers as (J1-J2)^2.
description: 13 pages, 6 figures More detailed explanations
Distinguished orbits and the L-S category of simply connected compact Lie groups
Creators: name: Hunziker, Markus
name: Sepanski, Mark R.
Publisher: name: arXiv
Year: 2009
Subjects: subject: General Topology (math.GN)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics
subject: 55C30

description: We show that the Lusternik-Schnirelmann category of a simple, simply connected, compact Lie group G is bounded above by the sum of the relative categories of certain distinguished conjugacy classes in G corresponding to the vertices of the fundamental alcove for the action of the affine Weyl group on the Lie algebra of a maximal torus of G.
description: 10 pages, 2 figures
ENVRI-FAIR D12.1 POPD - Requirement No. 1
Creators: name: Petzold, Andreas
Publisher: name: Zenodo
Year: 2019
Subjects: ENVRI-FAIR
deliverable
personal data protection
General Data Protection Regulation

description: The deliverable presents: Ethics self-assessment of ENVRI-FAIR Principles of personal data protection within the ENVRI-FAIR project The personal data protection and ethical guidelines for questionnaires and interviews inside the ENVRI-FAIR project Declaration of Conformity with requirements of the General Data Protection Regulation by the Data Protection Officer of Forschungszentrum Jülich as the coordinating institution
3D-QSAR, molecular docking, and molecular dynamics simulation of a novel thieno[3,4-d]pyrimidine inhibitor targeting human immunodeficiency virus type 1 reverse transcriptase
Creators: name: Chu, Han
name: He, Qing-xiu
name: Wang, Jun-wei
name: Deng, Ya-ting
name: Wang, Juan
name: Hu, Yong
name: Wang, Yuan-qiang
name: Lin, Zhi-hua
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) is one of the most attractive drug targets for the treatment of AIDS. In this study, 67 thieno[3,4-d]pyrimidine derivatives were selected as novel HIV-1 RT inhibitors to combat viral resistance, and were subjected to 3 D-QSAR studies using CoMFA, CoMSIA, and T-CoMFA. In the 3 D-QSAR study, two methods of ligand-based alignment and pharmacophore-based alignment were used. The results showed that CoMFA (n = 8; q2 = 0.594; r2 = 0.974) and CoMSIA (n = 7; q2 = 0.528; r2 = 0.965) have good stability and predictability. The molecular docking study showed that the hydrogen bonding and van der Waals interactions of key residues such as Leu100, Lys101, Val106, Phe227 and Pro236 play an important role in ligand-receptor binding. Based on these results, 12 new thieno[3,4-d]pyrimidines were designed and their activities were predicted; the results indicated that these compounds have good predictive activity and reasonably good ADME/T profiles. MD simulation analysis of 50 ns showed that compound 23j formed four hydrogen bonds with the residues (Lys101, Lys104, Val106 and Thr318), and binds more closely to HIV-1 RT than compound 23j. Furthermore, the group at the R1 position and the horseshoe-like conformation of these compounds are critical for the inhibitory activity and stability. These results provide useful insights for the discovery and design of a new generation of HIV-1 RT inhibitors. Communicated by Ramaswamy H. Sarma
Additional file 7 of Mediterranean diet in axial spondyloarthritis: an observational study in an Italian monocentric cohort
Creators: name: Ometto, Francesca
name: Ortolan, Augusta
name: Farber, Davide
name: Lorenzin, Mariagrazia
name: Dellamaria, Giulia
name: Cozzi, Giacomo
name: Favero, Marta
name: Valentini, Romina
name: Doria, Andrea
name: Ramonda, Roberta
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 7. Title: Cardiovascular risk indices in the study. Description: A table reporting the cardiovascular risk indices observed in the study.
Additional file 6 of Mediterranean diet in axial spondyloarthritis: an observational study in an Italian monocentric cohort
Creators: name: Ometto, Francesca
name: Ortolan, Augusta
name: Farber, Davide
name: Lorenzin, Mariagrazia
name: Dellamaria, Giulia
name: Cozzi, Giacomo
name: Favero, Marta
name: Valentini, Romina
name: Doria, Andrea
name: Ramonda, Roberta
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 6. Title: Characteristics according to the achievement of an improvement in ASDAS-CRP. Description: A table reporting the variables according to the achievement of an improvement in the ASDAS-CRP and the results of univariate analysis.
Abandoned Tracks: The Underground Railroad in Washington County, Pennsylvania
Creators: name: Mainwaring, W. Thomas
Publisher: name: University of Notre Dame
Year: 2023

description: In _Abandoned Tracks_, W. Thomas Mainwaring bridges the gap between scholarly and popular perceptions of the Underground Railroad. Historians have long recognized that many aspects of the Underground Railroad have been mythologized by emotion, memory, time, and wishful thinking. Mainwaring's book is a rich, in-depth attempt to separate fact from fiction in one local area, while also contributing to a scholarly discussion of the Underground Railroad by placing Washington County, Pennsylvania, in the national context.\u000a\u000aJust as the North was not consistent in its perspective on the Civil War and the slavery issue, the Underground Railroad had distinct regional variations. Washington County had a well-organized abolition movement, even though its members helped a comparatively small number of fugitive slaves escape, largely because of the small nearby slave population in what was then western Virginia. Its origins as a slave county make it an interesting case study of the transition from slavery to freedom and of the origins of black and white abolitionism. \u000a\u000a_Abandoned Tracks_ lends much to the ongoing scholarly debate about the extent, scope, and nature of the Underground Railroad. This book is written both for scholars of abolitionism and the Underground Railroad and for an audience interested in local history.
Comparison of the thin flux tube approximation with 3D MHD simulations
Creators: name: Chaouche, L. Yelles
name: Solanki, S. K.
name: Schuessler, M.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The structure and dynamics of small vertical photospheric magnetic flux concentrations has been often treated in the framework of an approximation based upon a low-order truncation of the Taylor expansions of all quantities in the horizontal direction, together with the assumption of instantaneous total pressure balance at the boundary to the non-magnetic external medium. Formally, such an approximation is justified if the diameter of the structure (a flux tube or a flux sheet) is small compared to all other relevant length scales (scale height, radius of curvature, wavelength, etc.). The advent of realistic 3D radiative MHD simulations opens the possibility of checking the consistency of the approximation with the properties of the flux concentrations that form in the course of a simulation. We carry out a comparative analysis between the thin flux tube/sheet models and flux concentrations formed in a 3D radiation-MHD simulation. We compare the distribution of the vertical and horizontal components of the magnetic field in a 3D MHD simulation with the field distribution in the case of the thin flux tube/sheet approximation. We also consider the total (gas plus magnetic) pressure in the MHD simulation box. Flux concentrations with super-equipartition fields are reasonably well reproduced by the second-order thin flux tube/sheet approximation. The differences between approximation and simulation are due to the asymmetry and the dynamics of the simulated structures.
Social change and high school opportunity in Guyana and Jamaica: 1957-1967
Creators: name: Bynoe, Jacob Galton
Publisher: name: University of British Columbia
Year: 2011

description: The approach to nationhood and democratic government in Guyana and Jamaica during the 1950's and 1960's was characterised by a determination to reduce inequalities in the distribution of goods and services among various socioeconomic groups. The thesis examines efforts made to lessen inequalities in educational opportunity, and assesses the results achieved. Specifically it enquires into the results of measures instituted during 1957 to 1967 to reduce inequalities in representation of different groups among high school free-place winners. The hypothesis examined is that despite legislative and organisational changes, formerly deprived groups still remain at a considerable disadvantage in their chances for high school selection. For both countries, groups are classified on the basis of four separate differentiating characteristics: parental occupation, regional background, sex, and type of previous school attended. For Guyana ethnic background is included because of peculiar ethno-historical problems in that country. Analysis of Ministry of Education records of all free-place winners in 1967 reveals that the position of the traditionally less privileged rural, and skilled, semi-skilled and unskilled groups remained far below public expectations and official claims. However, the disadvantages suffered in Guyana by East Indians as a group were rapidly and almost completely eliminated with increased participation of this group in the governmental machinery. The thesis also seeks to explore some of those social and economic factors that seemed historically to have frustrated efforts for the general expansion and equalisation of high school opportunity in the two territories. A study primarily of official records, speeches, reports, and other documentary evidence suggests that not only the scarcity of economic resources but the system of rewards, the kinds of employment opportunities available, and commitment on the part of various sections of the community to traditional elitist educational values were contributory factors. Equalizing educational opportunity requires not merely increasing the quantity of school places available, but diversifying the school programme to relate to various curricular interests and occupational aspirations. The success of such diversified programmes is affected by the actual patterns of curricular interests and occupational aspirations. The success of such diversified programmes is affected by the actual patterns of curricular interests and occupational aspirations of students, the investigation of which forms a subsidiary part of the thesis. Implications of findings for the further expansion and equalisation of high school opportunity in the two countries are discussed, and proposals for promoting these objectives outlined.
Supersymmetric quantum mechanics living on topologically nontrivial Riemann surfaces
Creators: name: Znojil, Miloslav
name: Jakubsky, Vit
Publisher: name: arXiv
Year: 2009
Subjects: subject: Mathematical Physics (math-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Supersymmetric quantum mechanics is constructed in a new non-Hermitian representation. Firstly, the map between the partner operators $H^{(\pm)}$ is chosen antilinear. Secondly, both these components of a super-Hamiltonian ${\cal H}$ are defined along certain topologically nontrivial complex curves $r^{(\pm)}(x)$ which spread over several Riemann sheets of the wave function. The non-uniqueness of our choice of the map ${\cal T}$ between "tobogganic" partner curves $r^{(+)}(x)$ and $r^{(-)}(x)$ is emphasized.
description: 14pp
Cosibelimab: First Approval
Creators: name: Lee, Arnold
Publisher: name: Adis Journals
Year: 2025
Subjects: Medicine

description: Declarations
Funding The preparation of this review was not supported by any external funding.
Authorship and Conflict of interest During the peer review process the manufacturer of the agent under review was offered an opportunity to comment on the article. Changes resulting from any comments received were made by the authors on the basis of scientific completeness and accuracy. Arnold Lee is a contracted employee of Adis International Ltd/Springer Nature, and declares no relevant conflicts of interest. All authors contributed to this article and are responsible for its content.
Ethics approval, Consent to participate, Consent to publish, Availability of data and material, Code availability not applicable
Additional information about this Adis Drug Review can be found here.
Abstract
Cosibelimab (UNLOXCYT; cosibelimab-ipdl) is an anti-PD-L1 antibody developed by Checkpoint Therapeutics for the treatment of advanced cancers, including metastatic or locally advanced cutaneous squamous cell carcinoma (mCSCC or laCSCC). Cosibelimab is the first approved anti-PD-L1 therapy in the USA for the treatment of adults with mCSCC or laCSCC who are not candidates for curative surgery or curative radiation. In contrast to other anti-PD-L1 antibodies, cosibelimab can induce antibody-dependent cell mediated cytotoxicity as it includes a functional Fc domain. This article summarizes the milestones in the development of cosibelimab leading to this first approval for this indication. 
© Springer Nature Switzerland AG 2025
Learning and Testing Algorithms for the Clifford Group
Creators: name: Low, Richard A.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Given oracle access to an unknown unitary C from the Clifford group and its conjugate, we give an exact algorithm for identifying C with O(n) queries, which we prove is optimal. We then extend this to all levels of the Gottesman-Chuang hierarchy (also known as the C_k hierarchy). Further, for unitaries not in the hierarchy itself but known to be close to an element of the hierarchy, we give a method of finding this close element. We also present a Clifford testing algorithm that decides whether a given black-box unitary is close to a Clifford or far from every Clifford.
description: 7 pages
3D-QSAR, molecular docking, and molecular dynamics simulation of a novel thieno[3,4-d]pyrimidine inhibitor targeting human immunodeficiency virus type 1 reverse transcriptase
Creators: name: Han, Chu
name: He, Qing-xiu
name: Wang, Jun-wei
name: Deng, Ya-ting
name: Juan, Wang
name: Yong, Hu
name: Wang, Yuan-qiang
name: Lin, Zhi-hua
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) is one of the most attractive drug targets for the treatment of AIDS. In this study, 67 thieno[3,4-d]pyrimidine derivatives were selected as novel HIV-1 RT inhibitors to combat viral resistance, and were subjected to 3D-QSAR studies using CoMFA, CoMSIA, and T-CoMFA. In the 3D-QSAR study, two methods of ligand-based alignment and pharmacophore-based alignment were used. The results showed that CoMFA (n = 8; q2=0.594; r2=0.974) and CoMSIA (n = 7; q2=0.528; r2=0.965) have good stability and predictability. The molecular docking study showed that the hydrogen bonding and van der Waals interactions of key residues such as Leu100, Lys101, Val106, Phe227, and Pro236 play an important role in ligand-receptor binding. Based on these results, 12 new thieno[3,4-d]pyrimidines were designed and their activities were predicted; the results indicated that these compounds have good predictive activity and reasonably good ADME/T profiles. MD simulation analysis of 50 ns showed that compound 23j formed four hydrogen bonds with the residues (Lys101, Lys104, Val106 and Thr318), and binds more closely to HIV-1 RT than compound 23j. Furthermore, the group at the R1 position and the horseshoe-like conformation of these compounds are critical for the inhibitory activity and stability. These results provide useful insights for the discovery and design of a new generation of HIV-1 RT inhibitors.
Phonon softening and anomalous mode near the $x_{c}=0.5$ quantum critical point in Ca$_{2-x}$Sr$_{x}$RuO$_4$
Creators: name: Moore, R. G.
name: Lumsden, M. D.
name: Stone, M. B.
name: Zhang, Jiandi
name: Chen, Y.
name: Lynn, J. W.
name: Jin, R.
name: Mandrus, D.
name: Plummer, E. W.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Inelastic neutron scattering is used to measure the temperature dependent phonon dispersion in Ca$_{2-x}$Sr$_{x}$RuO$_{4}$ ($x=0.4$, 0.6). The in-plane $Σ_{4}$ octahedral tilt mode softens significantly at the zone boundary of the high temperature tetragonal (HTT) \textit{I4}$_{\mathit{1}}$\textit{/acd} structure as the temperature approaches the transition to a low temperature orthorhombic (LTO) \textit{Pbca} phase. This behavior is similar to that in La$_2$CuO$_4$, but a new inelastic feature that is not found in the cuprate is present. An anomalous phonon mode is observed at energy transfers greater than the $Σ_{4}$ albeit with similar dispersion. This anomalous phonon mode never softens below $\sim 5$ meV, even for temperatures below the HTT-LTO transition. This mode is attributed to the presence of intrinsic structural disorder within the \textit{I4}$_{\mathit{1}}$\textit{/acd} tetragonal structure of the doped ruthenate.
description: 4 pages, 4 figures
Additional file 1 of Evaluation of implementation and effectiveness of digital adherence technology with differentiated care to support tuberculosis treatment adherence and improve treatment outcomes in Ethiopia: a study protocol for a cluster randomised trial
Creators: name: Tadesse, Amare W.
name: Mohammed, Zemedu
name: Foster, Nicola
name: Quaife, Matthew
name: McQuaid, Christopher Finn
name: Levy, Jens
name: van Kalmthout, Kristian
name: van Rest, Job
name: Jerene, Degu
name: Abdurhman, Tofik
name: Yazew, Hiwot
name: Umeta, Demekech G.
name: Assefa, Demelash
name: Weldemichael, Gedion T.
name: Bedru, Ahmed
name: Letta, Taye
name: Fielding, Katherine L.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Informed consent form and patient information sheet.
Structure and phase boundaries of compressed liquid hydrogen
Creators: name: Tamblyn, Isaac
name: Bonev, Stanimir A.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We have mapped the molecular-atomic transition in liquid hydrogen using first principles molecular dynamics. We predict that a molecular phase with short-range orientational order exists at pressures above 100 GPa. The presence of this ordering and the structure emerging near the dissociation transition provide an explanation for the sharpness of the molecular-atomic crossover and the concurrent pressure drop at high pressures. Our findings have non-trivial implications for simulations of hydrogen; previous equation of state data for the molecular liquid may require revision. Arguments for the possibility of a $1^{st}$ order liquid-liquid transition are discussed.
Principle of DNA recognition by sporulation-regulatory protein (Spo0A) in Bacillus subtilis
Creators: name: Shukla, Saransh
name: Kumar, Amit
name: Das, Debasish
name: Satpati, Priyadarshi
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology

description: Master sporulation-regulatory protein Spo0A binds to the cognate DNA sequence 5′-TGTCGAA-3′ (0 A-box) and control transcription of hundreds of genes in sporulating Bacilli. Thus, discrimination of similar near-cognate 0 A-box sequences (differing by a single base pair) by Spo0A is critical for accurate transcriptional control. The thermodynamics underlying the 0 A-box recognition by Spo0A is unknown. Recent X-ray structure of Spo0A from Bacillus subtilis in complex with cognate 0 A-box DNA sequence not only revealed the intricate atomic interaction network related to transcription activation but also provide an opportunity of directly computing the energetics of 0 A-box selectivity by Spo0A. Using the X-ray structure of cognate Spo0A-DNA complex as a template, we report computer simulations that quantitatively estimated the relative binding free energies of Spo0A to cognate and near-cognate 0 A-box sequences in B. subtilis. The results show that the strength of Spo0A binding preference for cognate 0 A-box sequence relative to its near-cognate analogue varies drastically along the location of the mismatch (5′→ 3′) in the 0 A-box sequence. Spo0A selectivity in favour of the cognate sequence is ensured by the loss of protein-DNA major groove interactions and/solvent exposure of the hydrophobic pockets in the near-cognate Spo0A-DNA complexes. The calculations provide a clue about the energetics of Spo0A discrimination between cognate and near-cognate 0 A-box sequences and its link to 3 D structures, which ensure fidelity of transcription initiation in B. subtilis. Communicated by Ramaswamy H. Sarma
Accountability of Australian local government authorities for national waste data from outsourced services
Creators: name: Oosthuizen, Heinrich
Publisher: name: University Of Tasmania
Year: 2023

description: The National Waste Policy Implementation Plan advocates the outsourcing of waste management services by contemplating 'multi-agency management arrangements' and 'active partnerships' between governments and industry (EPHC 2010a, p. 9). The Tasmanian Waste Strategy reinforces the national outsourcing approach by recommending that local government authorities (LGAs) engage in initiatives such as 'collaborative partnerships' with industry (Environmental Protection Authority 2009, pp. 3 & 9). The outsourcing of waste management services by LGAs to external service providers introduces another layer of accountability, resulting in the flow of waste data across organisational and geographical boundaries, which leads to a more complex reporting environment (Ball, Broadbent & Jarvis 2006). This thesis investigates whether the expectations of the federal Australian government with respect to the provision and dissemination of data through the outsourcing of municipal solid waste (MSW) are being fulfilled by posing the question: Are the accountability expectations of the Australian federal government satisfied in the outsourcing of waste management services by LGAs? This study broadly follows the institutional collective action (ICA) framework's (Feiock 2013) approach to explore the Australian federal government's accountability expectations, due to the collective action required by multiple LGAs and their service providers in different jurisdictions to provide national waste data (Bel, Fageda & Mur 2014). A multi-method approach combining textual narrative analysis of documents, archival records and direct observation supplemented by semi-structured interviews is followed (Yin 2014). The study found that managers of LGAs and their service providers are only willing to supply waste data through an accountability relationship with higher levels of government based on compliance with minimum legal requirements. The lack of adequate waste data collection tools constrains the collection of outsourced waste data, whilst the collaborative outsourcing practices of LGAs in Tasmania's Southern Waste Strategy Authority (SWSA) jurisdiction resulted in some complex forms of multi-agency arrangements and partnerships. In the absence of improved communication and consultation between all principals and agents, the accountability expectations of the Australian federal government for improved waste data collection systems will not be met.
Tevatron top physics
Creators: name: Wagner-Kuhr, Jeannine
Publisher: name: arXiv
Year: 2009
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: A summary of the most recent results on top quark physics obtained at Fermilab's Tevatron proton-antiproton collider, operating at a centre of mass energy of 1.96 TeV, is presented. Measurements of the top pair and single top quark production cross sections, the investigation of top quark decay properties, the precision measurement of the top quark mass as well as searches for physics beyond the standard model are discussed.
description: 7 pages, 3 figures, proceedings of LHC08 conference
Additional file 2 of Evaluation of implementation and effectiveness of digital adherence technology with differentiated care to support tuberculosis treatment adherence and improve treatment outcomes in Ethiopia: a study protocol for a cluster randomised trial
Creators: name: Tadesse, Amare W.
name: Mohammed, Zemedu
name: Foster, Nicola
name: Quaife, Matthew
name: McQuaid, Christopher Finn
name: Levy, Jens
name: van Kalmthout, Kristian
name: van Rest, Job
name: Jerene, Degu
name: Abdurhman, Tofik
name: Yazew, Hiwot
name: Umeta, Demekech G.
name: Assefa, Demelash
name: Weldemichael, Gedion T.
name: Bedru, Ahmed
name: Letta, Taye
name: Fielding, Katherine L.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2. Completed Spirit checklist.
Classical solutions for the Lorentz-violating and CPT-even term of the Standard Model Extension
Creators: name: Casana, R.
name: Ferreira, M. M.
name: Santos, C. E. H.
Publisher: name: arXiv
Year: 2008
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this work, we calculate the classical solutions for the electrodynamics stemming from the Lorentz-violating (LV) and CPT-even term of the Standard Model Extension. The solutions for point-like and extended charges are obtained from the wave equations by means of the Green method. A dipolar expansion is written for the field strengths. It is explicitly shown that charge and current generate first order effects for the magnetic and electric fields, respectively. Using the magnetic field generated by a macroscopic 1C charged sphere, we establish a stringent bound for the LV parameter:$κ\leq 10^{-16}.$
description: revtex style, 9 pages
Principle of DNA recognition by sporulation-regulatory protein (Spo0A) in Bacillus Subtilis
Creators: name: Shukla, Saransh
name: Kumar, Amit
name: Das, Debasish
name: Satpati, Priyadarshi
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology

description: Master sporulation-regulatory protein Spo0A binds to the cognate DNA sequence 5’-TGTCGAA-3’ (0A-box) and control transcription of hundreds of genes in sporulating Bacilli. Thus, discrimination of similar near-cognate 0A-box sequences (differing by a single base pair) by Spo0A is critical for accurate transcriptional control. The thermodynamics underlying the 0A-box recognition by Spo0A is unknown. Recent X-ray structure of Spo0A from Bacillus subtilis in complex with cognate 0A-box DNA sequence not only revealed the intricate atomic interaction network related to transcription activation but also provide an opportunity of directly computing the energetics of 0A-box selectivity by Spo0A. Using the x-ray structure of cognate Spo0A-DNA complex as a template, we report computer simulations that quantitatively estimated the relative binding free energies of Spo0A to cognate and near-cognate 0A-box sequences in Bacillus subtilis. The results show that the strength of Spo0A binding preference for cognate 0A-box sequence relative to its near-cognate analogue varies drastically along the location of the mismatch (5’→ 3’) in the 0A-box sequence. Spo0A selectivity in favour of the cognate sequence is ensured by the loss of protein-DNA major groove interactions and/ solvent exposure of the hydrophobic pockets in the near-cognate Spo0A-DNA complexes. The calculations provide a clue about the energetics of Spo0A discrimination between cognate and near-cognate 0A-box sequences and its link to 3D structures, which ensure fidelity of transcription initiation in Bacillus subtilis.
Paracladopelma Harnisch 1923
Creators: name: Namayandeh, Armin
name: Hudson, Patrick L.
name: Bogan, Daniel L.
name: Hudson, John P.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Chironomidae
Paracladopelma

description: Paracladopelma Harnisch, 1923
Our Paracladopelma records in Alaska include larvae of Paracladopelma doris group reported from the Arctic Coastal Plain (AWQMS 2005), larvae of Paracladopelma nereis (Townes, 1945) which we collected from the Yukon River, and adults of Paracladopelma winnelli Jackson, 1977 we collected from Montana Creek in Juneau in mid-August. The latter two species represent new faunistic records for Alaska. We also collected unknown larvae from Swan Lake in Ketchikan. Paracladopelma larvae are usually found in sandy substrates of lakes, streams and small rivers, and also in sediments of the profundal zone of deep lakes (Epler et al. 2013).
description: Published as part of Namayandeh, Armin, Hudson, Patrick L., Bogan, Daniel L. & Hudson, John P., 2024, Chironomidae (Diptera: Insecta) of Alaska, USA, with descriptions of new species and a checklist, pp. 1-95 in Zootaxa 5511 (1) on page 81, DOI: 10.11646/zootaxa.5511.1.1, http://zenodo.org/record/13848177
Investigating the pedagogical content knowledge of outdoor education teachers
Creators: name: Walker, CT
Publisher: name: University Of Tasmania
Year: 2023

description: Pedagogical content knowledge (PCK) is understood in contemporary literature as an essential component of the knowledge base required to deliver meaningful lessons and effective teaching. It is enacted through the blending of pedagogical and content knowledge (Shulman, 1987). Outdoor Education (OE) as a discipline is often undervalued as compared with mainstream subjects (Dyment & Potter, 2015). Recent OE literature has highlighted the signature pedagogies that are specific to OE (Thomas, 2015) and the bodies of content knowledge that Outdoor educators draw upon (Martin, 2008). PCK is a well-researched knowledge in other subjects, however there is little evidence of PCK research in OE. This research seeks to fill that gap through examining the PCK of Outdoor Education teachers as another element of quality teaching and learning in this subject. The overarching aim was to draw evidence of PCK from OE teachers' discussion and to inquire the effectiveness of the PCK Framework to determine suitable additions for the Framework. Contemporary educational and OE literature is blended throughout and examines PCK and the bodies of knowledge and significant pedagogies that OE offers. This research project included the interview of seven participants. The results and discussion is presented over two chapters and is integrated with the data analysis and literature. The results are presented in the PCK Framework Sections 1) Clearly PCK, 2) Content Knowledge in a Pedagogical Context, and 3) Pedagogical Knowledge in a Content Context. A majority of participants showed their capacity to draw knowledge from differing PCK categories (e.g. Curriculum Knowledge and Student Thinking) as a part of the teaching process. This research found that the following categories should be added to the PCK Framework for future research; 1) Knowledge of Place, 2) Facilitation Techniques, and 3) Group Management Techniques. This research contributes to OE through deciphering degrees of quality in teaching and learning and through contributing to the conversation of PCK research in OE.
Responding to a trust violation : the relative effectiveness of apology, denial, and reticence
Creators: name: Riddington, L
Publisher: name: University Of Tasmania
Year: 2023

description: Previous research has demonstrated that reticence, in which an individual does not respond to an allegation, is an ineffective response for repairing trust. This study examined whether reticence could be an effective response relative to apology and denial when the response is unambiguous about why it is utilised. This study also examined whether reticence could be an effective response when evidence has determined that the accused was guilty of the allegation. A sample of 162 participants was randomly allocated to receive a scenario that varied in terms of the violation and response type. Participants answered a short questionnaire to assess their trusting beliefs and intentions toward the accused. Participants were then provided with evidence of guilt, and asked to re-answer the questionnaire. Results indicated that reticence was an ineffective response before and after guilt when compared to apology and denial, regardless of the type of violation that had occurred. The implications derived from these findings suggest that the way individuals are currently asked to respond requires a change. Preventing an individual from responding is not facilitating the restoration of positive perceptions. Furthermore, for those who are guilty but wish to repair trust, reticence offers no benefits over denying the allegation.
Scaling Analysis of Affinity Propagation
Creators: name: Furtlehner, Cyril
name: Sebag, Michele
name: Zhang, Xiangliang
Publisher: name: arXiv
Year: 2009
Subjects: subject: Artificial Intelligence (cs.AI)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: We analyze and exploit some scaling properties of the Affinity Propagation (AP) clustering algorithm proposed by Frey and Dueck (2007). First we observe that a divide and conquer strategy, used on a large data set hierarchically reduces the complexity ${\cal O}(N^2)$ to ${\cal O}(N^{(h+2)/(h+1)})$, for a data-set of size $N$ and a depth $h$ of the hierarchical strategy. For a data-set embedded in a $d$-dimensional space, we show that this is obtained without notably damaging the precision except in dimension $d=2$. In fact, for $d$ larger than 2 the relative loss in precision scales like $N^{(2-d)/(h+1)d}$. Finally, under some conditions we observe that there is a value $s^*$ of the penalty coefficient, a free parameter used to fix the number of clusters, which separates a fragmentation phase (for $ss^*$) of the underlying hidden cluster structure. At this precise point holds a self-similarity property which can be exploited by the hierarchical strategy to actually locate its position. From this observation, a strategy based on \AP can be defined to find out how many clusters are present in a given dataset.
description: 28 pages, 14 figures, Inria research report