cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Assessing dependency in a multiethnic community cohort of individuals with Alzheimer’s disease
Creators: name: Meinerding, Maria
name: DeFeis, Brittany
name: Sunderaraman, Preeti
name: Azar, Martina
name: Lawless, Siobhan
name: Perez-Vivaldo, Carlos
name: Gu, Yian
name: Stern, Yaakov
name: Cosentino, Stephanie
Publisher: name: Columbia University
Year: 2018
Subjects: Alzheimer's disease
Dementia
Dementia--Patients--Care
Cross-cultural studies

description: Background and Objectives: Clinic-based studies of patients with Alzheimer’s disease (AD) have demonstrated the value of assessing dependence when characterizing patients’ functional status. The Dependence Scale, a validated tool to assess level of caregiving needs, is associated with markers of disease severity, cost, and progression, while offering independent functional information about patients. This study examines whether such associations between the Dependence Scale and markers of disease severity demonstrated in clinical cohorts are similarly exhibited in a multiethnic community population of individuals with AD. Research Design and Methods: One hundred fifty four elders with AD enrolled in the Predictors 3 cohort were assessed with the Dependence Scale, modified Mini-Mental State Examination (mMMS), instrumental (IADL) and basic (BADL) activities of daily living, and Clinical Dementia Rating (CDR) Scale, and were assigned an Equivalent Institutional Care (EIC) rating. Cross-sectional associations were examined using bivariate correlations and one-way analysis of variance analyses. Fisher-z tests examined differences in strengths of associations across previous clinic and current community cohorts. Results: Dependence Scale scores were associated with CDR (r = .20, p = .013), mMMS (r = −.23, p = .005), IADL (r = .39, p < .001), BADL (r = .65, p < .001), and EIC (r = .51, p < .001). Dependence was unassociated with ethnicity (F[3,144] = 1.027, p = .3822), age (r = .120, p = .145), and education (r = −.053, p = .519). The strength of the correlations was comparable across cohorts except that BADLs were more strongly associated with dependence (z = −4.60, p < .001) in the community cohort, and living arrangement was not associated with dependence (r = .13, p = .130). Discussion and Implications: Associations between the Dependence Scale and markers of disease severity in a clinic-based cohort of AD patients are similar to associations in a multiethnic community cohort of individuals diagnosed with AD. The Dependence Scale relates to markers of disease severity rather than demographic factors, and may offer an unbiased assessment of care required in multiethnic and community populations.
An Optimal and Model-Independent Measurement of the Intracluster Pressure Profile I: Methodology and First Applications
Creators: name: Aslanbeigi, Siavash
name: Lavaux, Guilhem
name: Hajian, Amir
name: Afshordi, Niayesh
Publisher: name: arXiv
Year: 2013
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present a statistically-optimal and model-independent method to extract the pressure profile of hot gas in the intracluster medium (ICM). Using the thermal Sunyaev-Zeldovich effect, we constrain the mean pressure profile of the ICM by appropriately considering all primary cosmic microwave background (CMB) and instrumental noise correlations, while using the maximum resolution and sensitivity of all frequency channels. As a first application, we analyze CMB maps of WMAP 9-year data through a study of the Meta-Catalogue of X-ray detected Clusters of galaxies (MCXC). We constrain the universal pressure profile out to 4R_500 with 15-sigma confidence, though our measurements are only significant out to R_200. Using a temperature profile constrained from X-ray observations, we measure the mean gas mass fraction out to R_200. Within statistical and systematic uncertainties, our constraints are compatible with the cosmic baryon fraction and the expected gas fraction in halos. While Planck multi-frequency CMB data are expected to reduce statistical uncertainties by a factor of 20, we argue that systematic errors in determining mass of clusters dominate the uncertainty in gas mass fraction measurements at the level of 20 percent.
Fritsch, Andreas: Index sententiarum ac locutionum. Handbuch lateinischer Sätze und Redewendungen
Creators: name: Albert, Sigrid
Publisher: name: Forum Classicum
Year: 2017

description: Rezension zu: Fritsch, Andreas: Index sententiarum ac locutionum. Handbuch lateinischer Sätze und Redewendungen. Saarbrücken: Verlag der Societas Latina. 1996. - IX + 625 S. - ISBN 3-923587- 23-6
description: Forum Classicum, Nr. 1 (1997): Forum Classicum
Graph Logics with Rational Relations
Creators: name: Barcelo, Pablo
name: Figueira, Diego
name: Libkin, Leonid
Publisher: name: arXiv
Year: 2013
Subjects: subject: Formal Languages and Automata Theory (cs.FL)
subject: FOS: Computer and information sciences

description: We investigate some basic questions about the interaction of regular and rational relations on words. The primary motivation comes from the study of logics for querying graph topology, which have recently found numerous applications. Such logics use conditions on paths expressed by regular languages and relations, but they often need to be extended by rational relations such as subword or subsequence. Evaluating formulae in such extended graph logics boils down to checking nonemptiness of the intersection of rational relations with regular or recognizable relations (or, more generally, to the generalized intersection problem, asking whether some projections of a regular relation have a nonempty intersection with a given rational relation). We prove that for several basic and commonly used rational relations, the intersection problem with regular relations is either undecidable (e.g., for subword or suffix, and some generalizations), or decidable with non-primitive-recursive complexity (e.g., for subsequence and its generalizations). These results are used to rule out many classes of graph logics that freely combine regular and rational relations, as well as to provide the simplest problem related to verifying lossy channel systems that has non-primitive-recursive complexity. We then prove a dichotomy result for logics combining regular conditions on individual paths and rational relations on paths, by showing that the syntactic form of formulae classifies them into either efficiently checkable or undecidable cases. We also give examples of rational relations for which such logics are decidable even without syntactic restrictions.
ACCESS MODELS IN THE PRACTICE OF THE PUBLICATIONS "JOURNAL OF MATHEMATICAL PHYSICS, ANALYSIS, GEOMETRY" AND "LOW TEMPERATURE PHYSICS"
Creators: name: MATSIEVSKY, Konstantin
name: LOBOYKO, Valentina
Publisher: name: Zenodo
Year: 2022

description: Проведено аналіз моделей публікацій відкритого доступу виданнь «Журнал математичної фізики, аналізу, геометрії» та «Фізика низьких температур». Розглядаються різні стратегії та шляхи впровадження кращих національних практик відкритого доступу. Наведено приклади бізнес-моделей, обговорено їх вплив на наукометричні показники. Зазначається, що шлях до інновацій відкритого доступу є пріоритетним на найближчі роки для наукових журналів в Україні. The article analyzes the models of Open Access publications based on the experience of the “Journal of Mathematical Physics, Analysis, Geometry” and the Journal of “Low Temperature Physics”. Different strategies and ways of implementing the best national practices of Open Access are considered. Examples of business models are given, their impact on bibliometric indicators is discussed. It is noted that the path to Open Access innovation is a priority for scientific journals in Ukraine in the com
The presence of moderate extrapyramidal signs predicts poorer outcomes in a community‐based cohort of multi‐ethnic demented elders: Developing topics
Creators: name: Kociolek, Anton J.
name: Fernandez, Kayri Kate
name: Gu, Yian
name: Cosentino, Stephanie
name: Zhu, Carolyn W.
name: Stern, Yaakov
Publisher: name: Columbia University
Year: 2020
Subjects: Extrapyramidal disorders
Dementia
Outcome assessment (Medical care)
Cultural pluralism

description: Background: Extrapyramidal signs (EPS) are a common feature of Alzheimer's Disease (AD) associated with worse outcomes in observational studies of dementia. Prior studies have been primarily conducted in predominately white, clinic‐based samples. Less is known regarding the role of EPS in the disease course of dementia in ethnic minority and non‐clinic‐based populations. Method: Predictors 3 (P3) is a multi‐ethnic community‐based cohort study of dementia. Recruitment began in 2011 and is ongoing. Participants are evaluated annually by trained investigators. 142 P3 participants with a baseline diagnosis of probable dementia were selected for this study. Moderate EPS was defined as a score of 2 or more on selected items from the Unified Parkinson's Disease Rating Scale. The cognitive endpoint was defined as a score of <= 10 on the Folstein MMSE, the functional endpoint as a score of >= 10 on the 17‐point Blessed Dementia Rating Scale, and the institutional equivalent endpoint as need for equivalent to nursing home care. Adjusted Cox models were fitted for time to death and cognitive, functional, and institutional equivalent endpoints with baseline moderate EPS as predictor. Effect modification was assessed by fitting cross‐product terms for moderate EPS by ethnicity, sex, age, education, and APOE polymorphism. Result: Mean follow‐up time was 3.61 years (range: 0.29 ‐ 7.50, SD = 1.95). 33 participants (23.2%) had moderate EPS at baseline. 53 died (37.3%), 23 (17.2%) reached the cognitive endpoint, 45 (36.3%) the functional endpoint, and 44 (37.9%) the institutional equivalent endpoint post‐baseline. Moderate EPS at baseline was significantly associated with an increased hazard of death (HR = 2.57, 95% CI = 1.30, 5.10) and of reaching the functional endpoint (5.59, 95% CI = 2.36, 13.27). Associations between moderate EPS and the cognitive and institutional equivalent endpoints were not statistically significant. No evidence was found for effect modification of associations on either additive or multiplicative scales. Conclusion: In a multi‐ethnic community‐dwelling cohort of demented elders, we found that baseline moderate EPS significantly predicted time to death and time to functional endpoint, but not time to cognitive and institutional equivalent care endpoints. These findings confirm those of previous studies conducted on predominately white, clinic‐based samples.
[Gymnasium 104, 1997, H. 2 / Hermes 125, 1997, H. 1 / Historia 46, 1997, H. 1 ...]
Creators: name: Mensching, Eckart
Publisher: name: Forum Classicum
Year: 2017

description: -
description: Forum Classicum, Nr. 2 (1997): Forum Classicum
First demonstration of a TES based cryogenic Li$_2$MoO$_4$detector for neutrinoless double beta decay search
Creators: name: Bratrud, G.
name: Chang, C. L.
name: Chen, R.
name: Cudmore, E.
name: Figueroa-Feliciano, E.
name: Hong, Z.
name: Kennard, K. T.
name: Lewis, S.
name: Lisovenko, M.
name: Mateo, L. O.
name: Novati, V.
name: Novosad, V.
name: Oliveri, E.
name: Ren, R.
name: Scarpaci, J. A.
name: Schmidt, B.
name: Wang, G.
name: Winslow, L.
name: Yefremenko, V. G.
name: Zhang, J.
name: Baxter, D.
name: Hollister, M.
name: James, C.
name: Lukens, P.
name: Temples, D. J.
Publisher: name: arXiv
Year: 2024
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Experiment (nucl-ex)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: Cryogenic calorimetric experiments to search for neutrinoless double-beta decay ($0νββ$) are highly competitive, scalable and versatile in isotope. The largest planned detector array, CUPID, is comprised of about 1500 individual Li$_2^{100}$MoO$_{4}$ detector modules with a further scale up envisioned for a follow up experiment (CUPID-1T). In this article, we present a novel detector concept targeting this second stage with a low impedance TES based readout for the Li$_2$MoO$_{4}$ absorber that is easily mass-produced and lends itself to a multiplexed readout. We present the detector design and results from a first prototype detector operated at the NEXUS shallow underground facility at Fermilab. The detector is a 2-cm-side cube with 21$\,$g mass that is strongly thermally coupled to its readout chip to allow rise-times of $\sim$0.5$\,$ms. This design is more than one order of magnitude faster than present NTD based detectors and is hence expected to effectively mitigate backgrounds generated through the pile-up of two independent two neutrino decay events coinciding close in time. Together with a baseline resolution of 1.95$\,$keV (FWHM) these performance parameters extrapolate to a background index from pile-up as low as $5\cdot 10^{-6}\,$counts/keV/kg/yr in CUPID size crystals. The detector was calibrated up to the MeV region showing sufficient dynamic range for $0νββ$ searches. In combination with a SuperCDMS HVeV detector this setup also allowed us to perform a precision measurement of the scintillation time constants of Li$_2$MoO$_{4}$. The crystal showed a significant fast scintillation emission with O(10$\,μ$s) time-scale, more than an order below the detector response of presently considered light detectors suggesting the possibility of further progress in pile-up rejection through better light detectors in the future.
Odor Identification Impairment and Change with Cholinesterase Inhibitor Treatment in Mild Cognitive Impairment
Creators: name: Devanand, Devangere P.
name: Liu, Xinhua
name: Chunga, Richard E.
name: Cohen, Hannah
name: Andrews, Howard F.
name: Schofield, Peter W.
name: Stern, Yaakov
name: Huey, Edward D.
name: Choi, Jongwoo
name: Pelton, Gregory H.
Publisher: name: Columbia University
Year: 2020
Subjects: Cholinesterase inhibitors
Smell
Mild cognitive impairment
Alzheimer's disease

description: Background: Anticholinergic challenge can induce odor identification impairment that indicates Alzheimer’s disease (AD) pathology, and short-term change in odor identification impairment with cholinesterase inhibitor (CheI) treatment may predict longer term cognitive outcomes. Objective: In patients with mild cognitive impairment (MCI) treated prospectively with donepezil, a CheI, for 52 weeks, to determine if 1) acute decline in odor identification ability with anticholinergic challenge can predict cognitive improvement, and 2) change in odor identification over 8 weeks can predict cognitive improvement. Methods: MCI was diagnosed clinically without AD biomarkers. At baseline, the University of Pennsylvania Smell identification Test (UPSIT) was administered before and after an anticholinergic atropine nasal spray challenge. Donepezil was started at 5 mg daily, increased to 10 mg daily if tolerated, and this dose was maintained for 52 weeks. Main outcomes were ADAS-Cog total score and Selective Reminding Test (SRT) total immediate recall score measured at baseline, 26 and 52 weeks. Results: In 100 study participants, mean age 70.14 (SD 9.35) years, atropine-induced decrease in UPSIT score at baseline was not associated with change in ADAS-Cog or SRT scores over 52 weeks. Change in UPSIT score from 0 to 8 weeks did not show a significant association with change in the ADAS-Cog or SRT measures over 52 weeks. Conclusion: These negative findings in a relatively large sample of patients with MCI did not replicate results in much smaller samples. Change in odor identification with anticholinergic challenge, and over 8 weeks, may not be useful predictors of cognitive improvement with CheI in patients with MCI.
Parity nonconservation in Fr-like actinide and Cs-like rare-earth-metal ions
Creators: name: Roberts, B. M.
name: Dzuba, V. A.
name: Flambaum, V. V.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: Parity nonconservation amplitudes are calculated for the 7s-6d transitions of the francium isoelectronic sequence (Fr, Ra +, Ac 2+, Th 3+, Pa 4+, U 5+ and Np 6+) and for the 6s-5d transitions of the cesium isoelectronic sequence (Cs, Ba +, La 2+, Ce 3+ and Pr 4+). We show in particular that isotopes of La 2+, Ac 2+ and Th 3+ ions have strong potential in the search for new physics beyond the standard model - the PNC amplitudes are large, the calculations are accurate and the nuclei are practically stable. In addition, 232-Th 3+ ions have recently been trapped and cooled [C. J. Campbell et al., Phys. Rev. Lett. 102, 233004 (2009)]. We also extend previous works by calculating the s-s PNC transitions in Ra + and Ba +, and provide new calculations of several energy levels, and electric dipole and quadrupole transition amplitudes for the Fr-like actinide ions.
description: 7 pages, 1 figure. calculations expanded
Analysis and optimal control theory for a phase field model of Caginalp type with thermal memory
Creators: name: Colli, Pierluigi
name: Signori, Andrea
name: Sprekels, Jürgen
Publisher: name: Weierstrass Institute
Year: 2021
Subjects: subject: Phase field model
subject: thermal memory
subject: well-posedness
subject: optimal control
subject: first-order necessary optimality conditions
subject: adjoint system
subject: 35K55
subject: 35K51
subject: 49J20
subject: 49K20
subject: 49J50

description: A nonlinear extension of the Caginalp phase field system is considered that takes thermal memory into account. The resulting model, which is a first-order approximation of a thermodynamically consistent system, is inspired by the theories developed by Green and Naghdi. Two equations, resulting from phase dynamics and the universal balance law for internal energy, are written in terms of the phase variable (representing a non-conserved order parameter) and the so-called thermal displacement, i.e., a primitive with respect to time of temperature. Existence and continuous dependence results are shown for weak and strong solutions to the corresponding initial-boundary value problem. Then, an optimal control problem is investigated for a suitable cost functional, in which two data act as controls, namely, the distributed heat source and the initial temperature. Fréchet differentiability between suitable Banach spaces is shown for the control-to-state operator, and meaningful first-order necessary optimality conditions are derived in terms of variational inequalities involving the adjoint variables. Eventually, characterizations of the optimal controls are given.
Characterization of bolometric Light Detectors for rare event searches
Creators: name: Beeman, J. W.
name: Bellini, F.
name: Casali, N.
name: Cardani, L.
name: Dafinei, I.
name: Di Domizio, S.
name: Ferroni, F.
name: Gironi, L.
name: Nagorny, S.
name: Orio, F.
name: Pattavina, L.
name: Pessina, G.
name: Piperno, G.
name: Pirro, S.
name: Previtali, E.
name: Rusconi, C.
name: Tomei, C.
name: Vignati, M.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences
subject: J.2

description: Bolometers have proven to be very good detectors to search for rare processes thanks to their excellent energy resolution and their low intrinsic background. Further active background rejection can be obtained by the simultaneous readout of the heat and light signals produced by particles interacting in scintillating bolometers, as proposed by the LUCIFER experiment. In this framework, the choice of the light detector and the optimization of its working conditions play a crucial role. In this paper, we report a study of the performances of a Germanium bolometric light detector in terms of signal amplitude, energy resolution and signal time development. The impact of various operational parameters on the detector performances is discussed.
description: 13 pages, 12 figures
MicroCT images of chick embryos HH12, 14, 16
Creators: name: Metscher, Brian
Publisher: name: Zenodo
Year: 2021
Subjects: X-ray microtomography
chick development
3D imaging

description: MicroCT images of whole chick embryos HH12, 14, 16. Xradia MicroXCT, PTA staining.
Intact global cognitive and olfactory ability predicts lack of transition to dementia
Creators: name: Devanand, Devangere P.
name: Lee, Seonjoo
name: Luchsinger, Jose A.
name: Andrews, Howard F.
name: Goldberg, Terry E.
name: Huey, Edward D.
name: Schupf, Nicole
name: Manly, Jennifer J.
name: Stern, Yaakov
name: Kreisl, William Charles
name: Mayeux, Richard Paul
Publisher: name: Columbia University
Year: 2019
Subjects: Dementia
Cognition
Smell
Dementia--Diagnosis

description: Introduction: Odor identification deficits characterize Alzheimer's disease and other dementias. We examined if intact performance on brief cognitive and odor identification tests predicts lack of transition to dementia. Methods: In an urban community, 1037 older adults without dementia completed the 40‐item University of Pennsylvania Smell Identification Test, which includes the 12‐item Brief Smell Identification Test (B‐SIT). Data from 749 participants followed up for 4 years were analyzed. Results: In covariate‐adjusted survival analyses, impairment on the Blessed Orientation Memory Concentration Test and B‐SIT each predicted dementia (n = 109), primarily Alzheimer's disease (n = 101). Among participants with intact olfactory (B‐SIT ≥ 11/12 correct) and cognitive (Blessed Orientation Memory Concentration Test ≤ 5/28 incorrect) ability, 3.4% (4/117) transitioned to dementia during follow‐up with no transitions in the 70‐75 and 81‐83 years age group quartiles. Discussion: Odor identification testing adds value to global cognitive testing, and together can identify individuals who rarely transition to dementia, thereby avoiding unnecessary diagnostic investigation.
$Z_{2}$ fractionalized Chern/topological insulators in an exactly soluble correlated model
Creators: name: Zhong, Yin
name: Wang, Yu-Feng
name: Luo, Hong-Gang
Publisher: name: arXiv
Year: 2013
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: In this paper we propose an exactly soluble model in two-dimensional honeycomb lattice, from which two phases are found. One is the usual Chern/topological insulating state and the other is an interesting $Z_2$ fractionalized Chern/topological insulator. While their bulk properties are similar, the edge-states of physical electrons are quite different. The single electron excitation of the former shows a free particle-like behavior while the latter one is gapped, which provides a definite signature to identify the fractionalized states. The transition between these two phases is found to fall into the 3D Ising universal class. Significantly, near the quantum transition point the physical electron in the edge-states shows strong Luttinger liquid behavior. An extension to the interesting case of the square lattice is also made. In addition, we also discuss some relationship between our exactly soluble model and various Hubbard-like models existing in the literature. The essential difference between the proposed $Z_{2}$ fractionalized Chern insulator and the hotly pursued fractional Chern insulator is also pointed out. The present work may be helpful for further study on the fractionalized insulating phase and related novel correlated quantum phases.
description: 13pages,no figures, some physics clarified and acknowledgement updated
Physical exercise and activity may be important in reducing dementia risk at any age
Creators: name: Mortimer, James A.
name: Stern, Yaakov
Publisher: name: Columbia University
Year: 2019
Subjects: Cognition
Dementia
Aerobic exercises

description: Lifestyle interventions such as physical exercise may provide inexpensive and effective ways to delay the onset of cognitive decline and dementia. If we are able to reduce Alzheimer neuropathology in the future as now appears possible,1 combining pharmacologic and lifestyle interventions will likely provide the best prevention for cognitive decline and dementia. In this respect, prevention of dementia and cognitive impairment would be similar to current preventive treatments for diabetes and vascular disease, where both types of interventions are used.
Dependence clusters in Alzheimer’s disease and Medicare expenditures: A longitudinal analysis from the Predictors Study: Health services research/Cost of care
Creators: name: Zhu, Carolyn W.
name: Lee, Seonjoo
name: Ornstein, Katherine A.
name: Cosentino, Stephanie
name: Gu, Yian
name: Andrews, Howard F.
name: Stern, Yaakov
Publisher: name: Columbia University
Year: 2020
Subjects: Alzheimer's disease
Dementia--Patients--Care
Medicare
Medical care, Cost of--Evaluation

description: Background: Dependence has been proposed as a holistic, transparent, and meaningful representation of dementia disease severity to quantify and stage disease progression. Modeling clusters in dependence trajectories can help understand changes over time in the course of dementia and related cost of care. Method: 199 initially community‐living patients with probable AD in early stages of the disease were recruited to the Predictors 2 Study from three academic medical centers in the US. Patients were followed for up to 10 years and had at least two Dependence Scale (DS) recorded. Non‐parametric K‐means cluster analysis for longitudinal data (KmL) was used to identify dependence clusters. Medicare expenditures (1999‐2010) were compared between clusters at 6‐month intervals and cumulatively over 5 years. Result: KmL identified two distinct DS clusters: (A) high initial dependence, faster decline, and (B) low initial dependence, slower decline. At baseline, DS score in cluster A was on average 2.25 points higher than in cluster B (p<0.0001). DS scores in both clusters steadily worsened (cluster A by 0.74±0.038 points, cluster B by 0.42±0.038 points every 6 month, both p<0.001), with significant between‐cluster differential rate of change over time (p<0.0001). At baseline, patients in cluster A were older, more likely to be female, have worse functioning and cognition, and more likely to have psychiatric symptoms than those in cluster B. Average per person Medicare expenditures in a 6‐month interval was higher in cluster A than B ($5,456 vs. $2,715). Adjusting for patient characteristics, cluster A was associated with an average of $1,554 higher Medicare expenditures every 6 months cluster B. By year 5, differences in expenditures between clusters accumulated to $54,557 per person in cluster A, twice as high as $27,153 for cluster B. Conclusion: Distinct DS clusters with subtle differences at baseline and rates of decline over time were associated with widening difference in expenditures over time. Dependence is a useful measure to capture long‐term costs associated with dementia. Better characterization of dependence clusters has significant implications for understanding disease progression, trial design and care planning.
Two-dimensional gradient Ricci solitons revisited
Creators: name: Bernstein, Jacob
name: Mettler, Thomas
Publisher: name: arXiv
Year: 2013
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 53C44

description: In this note, we complete the classification of the geometry of non-compact two-dimensional gradient Ricci solitons. As a consequence, we obtain two corollaries: First, a complete two-dimensional gradient Ricci soliton has bounded curvature. Second, we give examples of complete two-dimensional expanding Ricci solitons with negative curvature that are topologically disks and are not hyperbolic space.
description: 15 pages, 3 figures. Corrected statement and proof of Theorem 2 and removed Corollary 1
Publius Terentius Afer: So tun als ob. Ein Divertimento. Eunuchus
Creators: name: Wölke, Hansjörg
Publisher: name: Forum Classicum
Year: 2017

description: Rezension zu: Publius Terentius Afer: So tun als ob. Ein Divertimento. Eunuchus. Übers. u. Adapt.: Oliver Humberg u. Martin Fresen. Velbert: Humberg & Fresen Buchverlag 1991. 64 S. (ISBN 3-9802788-1-6; Aufführungsrechte, auch Bezug jetzt von: Buchverlag Oliver Humberg, Moltke- str. 43, 42115 Elberfeld)
description: Forum Classicum, Nr. 3 (1997): Forum Classicum
A remarkable basic hypergeometric identity
Creators: name: Krattenthaler, Christian
name: Zudilin, Wadim
Publisher: name: arXiv
Year: 2024
Subjects: subject: Number Theory (math.NT)
subject: Mathematical Physics (math-ph)
subject: Classical Analysis and ODEs (math.CA)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 11A07, 11B65, 11R18, 33D15, 33F10

description: We give a closed form for $quotients$ of truncated basic hypergeometric series where the base $q$ is evaluated at roots of unity.
description: $1+2+\dots+N = 1\cdot2\dotsb N$ pages
Using a novel clinical prediction algorithm to enhance clinical trials in Alzheimer's disease: Refining clinical trials for dementia prevention
Creators: name: Stern, Yaakov
name: Stallard, Eric
Publisher: name: Columbia University
Year: 2020
Subjects: Alzheimer's disease
Clinical trials

description: Background: The course of Alzheimer’s disease (AD) is heterogenous, in part because of individual heterogeneity in the disease’s underlying biological changes. This heterogeneity can influence the efficacy and interpretation of clinical trials. We developed a Grade of Membershp (GoM) prediction model that can accurately predict time to important disease endpoints in individual patients. Here we present the model and discuss its implications for clinical trials in AD. Method: The GoM model was developed in the Predictors 2 cohort. It incorporates 73 time‐varying categorical covariates spanning 11 measurement domains including cognition, function; psychiatric symptoms, motor signs/symptoms and APOE genotype. We then tested the model in the separate Predictors 1 data set, consisting of 252 patients with mild AD at first visit who were followed semi‐annually for up to 10 years. We applied the GoM model to data from each patient‘s first visit, which generates a baseline GoM status. We then generated predicted survival functions and used life table analyses to compare predicted and actual survival. Result: The figure summarizes the actual survival curve for all patients, and the survival curves as predicted from the GoM model. The predictions fell well within the confidence intervals around the actual survival curve. We also divided the estimated survival into quintiles, and compared the predicted versus actual quintile‐specific survival curves. Again, the predictions generally fell well within the confidence intervals around the actual survival curves. Conclusion: Our new GoM model, applied to an external population, generated accurate predictions of survival using only the data from the patient’s first visit. Any variable in the model can also be predicted, including specific cognitive and functional outcomes. The GoM model has great potential for the design and interpretation of clinical trials in three ways: 1) randomization can be optimized or evaluated by comparing the distribution of GoM status in control and treatment groups; 2) the model should predict disease progression well in the placebo group; individual deviations from model prediction in the treatment group could indicate specific treatment effects; 3) with sufficient validation, the model itself could be used in the place of a placebo group.
Evolution of emotions on networks leads to the evolution of cooperation in social dilemmas
Creators: name: Szolnoki, Attila
name: Xie, Neng-Gang
name: Ye, Ye
name: Perc, Matjaz
Publisher: name: arXiv
Year: 2013
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Social and Information Networks (cs.SI)
subject: Populations and Evolution (q-bio.PE)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences
subject: FOS: Biological sciences

description: We show that the resolution of social dilemmas on random graphs and scale-free networks is facilitated by imitating not the strategy of better performing players but rather their emotions. We assume sympathy and envy as the two emotions that determine the strategy of each player by any given interaction, and we define them as probabilities to cooperate with players having a lower and higher payoff, respectively. Starting with a population where all possible combinations of the two emotions are available, the evolutionary process leads to a spontaneous fixation to a single emotional profile that is eventually adopted by all players. However, this emotional profile depends not only on the payoffs but also on the heterogeneity of the interaction network. Homogeneous networks, such as lattices and regular random graphs, lead to fixations that are characterized by high sympathy and high envy, while heterogeneous networks lead to low or modest sympathy but also low envy. Our results thus suggest that public emotions and the propensity to cooperate at large depend, and are in fact determined by the properties of the interaction network.
description: 7 two-column pages, 7 figures; accepted for publication in Physical Review E
Volumetric properties of corrosive gases
Creators: name: Golding, Bert Henry
Publisher: name: California Institute of Technology
Year: 1954
Subjects: subject: Chemical Engineering
subject: FOS: Chemical engineering

description: Part I: The volumetric behavior of nitrogen dioxide was determined experimentally at temperatures between 100 and 340?F for pressures up to 2000 pounds per square inch. The two-phase data are compared with the results obtained by other investigators. The measurements were made in a stainless steel cell of essentially constant volume, and the experimental apparatus is described.

Part II: The volumetric behavior of nitric oxide was determined experimentally at temperatures between 40 and 220?F for pressures up to 2500 pounds per square inch. The measurements were made in a variable volume container of chrome-nickel stainless steel with mercury as the confining fluid. Reaction between the mercury and the nitric oxide was experienced at temperatures of 280?F and above.

Part III: The volumetric behavior of six mixtures in the binary system nitric oxide - nitrogen dioxide was determined in an essentially constant volume apparatus over a temperature range from 10 to 340?F. The composition range was from 0 to 20 weight percent of nitric oxide, and the maximum pressure obtained was approximately 600 pounds per square inch.

Part IV. The volumetric behavior of four mixtures in the binary system hydrogen sulfide - water was determined in an essentially constant volume apparatus over a temperature range from 10 to 340?F.

Part V:	Thermodynamic properties of nitric oxide were calculated from the data presented in Part II of this thesis. Values of entropy, enthalpy, and of the ratio of fugacity to pressure are presented at temperatures of 40, 100, 160, and 220?F for pressures up to 2500 pounds per square inch.

Part VI: Thermodynamic properties of nitrogen dioxide were calculated from the data presented in Part I of this thesis. Values of entropy, enthalpy, and of the ratio of fugacity to pressure are presented for the equilibrium material, the molecular weight of which is taken as that of nitrogen dioxide, at temperatures between 160 and 340?F for pressures up to 1000 pounds per square inch.
New Constraints on General Slepton Flavor Mixing
Creators: name: Arana-Catania, M.
name: Heinemeyer, S.
name: Herrero, M. J.
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We explore the phenomenological implications on charged lepton flavor violating (LFV) processes from slepton flavor mixing within the Minimal Supersymmetric Standard Model. We work under the model-independent hypothesis of general flavor mixing in the slepton sector, being parametrized by a complete set of dimensionless delta^AB_ij (A,B = L,R; i,j = 1, 2, 3) parameters. The present upper bounds on the most relevant LFV processes, together with the requirement of compatibility in the choice of the MSSM parameters with the recent LHC and (g-2) data, lead to updated constraints on all slepton flavor mixing parameters. A comparative discussion of the most effective LFV processes to constrain the various generation mixings is included.
description: 42 pages, 19 figures. Minor changes, version to appear in PRD
On the iterations of certain maps $x \mapsto k \cdot(x+x^{-1})$ over finite fields of odd characteristic
Creators: name: Ugolini, Simone
Publisher: name: arXiv
Year: 2013
Subjects: subject: Dynamical Systems (math.DS)
subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 37P05

description: In this paper we describe the dynamics of certain rational maps of the form $k \cdot (x+x^{-1})$ over finite fields of odd characteristic.
description: 27 pages, expanded version with improved proofs and examples
Brain-predicted age difference score is related to specific cognitive functions: A multi-site replication analysis
Creators: name: Boyle, Rory
name: Jollans, Lee
name: Rueda-Delgado, Laura M.
name: Rizzo, Rossella
name: Yener, Görsev G.
name: McMorrow, Jason P.
name: Knight, Silvin P.
name: Carey, Daniel
name: Robertson, Ian H.
name: Emek-Savaş, Derya D.
name: Stern, Yaakov
name: Kenny, Rose Anne
name: Whelan, Robert
Publisher: name: Columbia University
Year: 2020
Subjects: Cognition
Brain--Aging
Magnetic resonance imaging
Biochemical markers
Machine learning

description: Brain-predicted age difference scores are calculated by subtracting chronological age from ‘brain’ age, which is estimated using neuroimaging data. Positive scores reflect accelerated ageing and are associated with increased mortality risk and poorer physical function. To date, however, the relationship between brain-predicted age difference scores and specific cognitive functions has not been systematically examined using appropriate statistical methods. First, applying machine learning to 1359 T1-weighted MRI scans, we predicted the relationship between chronological age and voxel-wise grey matter data. This model was then applied to MRI data from three independent datasets, significantly predicting chronological age in each dataset: Dokuz Eylül University (n = 175), the Cognitive Reserve/Reference Ability Neural Network study (n = 380), and The Irish Longitudinal Study on Ageing (n = 487). Each independent dataset had rich neuropsychological data. Brain-predicted age difference scores were significantly negatively correlated with performance on measures of general cognitive status (two datasets); processing speed, visual attention, and cognitive flexibility (three datasets); visual attention and cognitive flexibility (two datasets); and semantic verbal fluency (two datasets). As such, there is firm evidence of correlations between increased brain-predicted age differences and reduced cognitive function in some domains that are implicated in cognitive ageing.
Nuclear magnetic resonance spectroscopy cyclopropane derivatives
Creators: name: Patel, Dinshaw J.
Publisher: name: California Institute of Technology
Year: 1963
Subjects: Chemistry

description: Chemical shifts and coupling constants have been determined from the analysis of proton nuclear magnetic resonance spectra for a series of cyclopropane derivatives . The geminal and vicinal cyclopropyl couplings have opposite signs. Additional ^(13)C-H coupling constants have been obtained for cyclopropanes which support the conclusion that the hybridization in cyclopropanes is close to sp^2. The chemical shifts for several cyclopropanes seem consistent with a ring-current effect.
Antiviral therapy: Valacyclovir Treatment of Alzheimer’s Disease (VALAD) Trial: protocol for a randomised, double-blind, placebo-controlled, treatment trial
Creators: name: Devanand, Devangere P.
name: Andrews, Howard F.
name: Kreisl, William Charles
name: Razlighi, Qolamreza R.
name: Gershon, Anne A.
name: Stern, Yaakov
name: Mintz, Akiva
name: Wisniewski, Thomas
name: Acosta, Edward
name: Pollina, Julianna
name: Katsikoumbas, Mariasofia
name: Bell, Karen L.
name: Pelton, Gregory H.
name: Deliyannides, Deborah A.
name: Prasad, K. M.
name: Huey, Edward D.
Publisher: name: Columbia University
Year: 2020
Subjects: Antiviral agents--Therapeutic use
Clinical trials
Alzheimer's disease

description: Mechanisms underlying resilience in ageing Y Stern, G Chételat, C Habeck, EM Arenaza-Urquijo, P Vemuri, A Estanga, ...Nature Reviews Neuroscience 20 (4), 246-246
Survival of the Scarcer in Space
Creators: name: Santos, Renato Vieira dos
name: Dickman, Ronald
Publisher: name: arXiv
Year: 2013
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: The dynamics leading to extinction or coexistence of competing species is of great interest in ecology and related fields. Recently a model of intra- and interspecific competition between two species was proposed by Gabel et al. [Phys. Rev. E 87 (2013) 010101], in which the scarcer species (i.e., with smaller stationary population size) can be more resistant to extinction when it holds a competitive advantage; the latter study considered populations without spatial variation. Here we verify this phenomenon in populations distributed in space. We extend the model of Gabel et al. to a d-dimensional lattice, and study its population dynamics both analytically and numerically. Survival of the scarcer in space is verified for situations in which the more competitive species is closer to the threshold for extinction than is the less competitive species, when considered in isolation. The conditions for survival of the scarcer species, as obtained applying renormalization group analysis and Monte Carlo simulation, differ in detail from those found in the spatially homogeneous case. Simulations highlight the speed of invasion waves in determining the survival times of the competing species.
description: 19 pages, 11 figures. In Journal of Statistical Mechanics 2013
Freiheit, Zeit, Geduld, Kooperation und Verantwortung. Eine Antwort auf H. Schulz „Vom ,Arbeitsunterricht‘ zur ,Handlungsorientierung‘“ (Forum Classicum 4/97)
Creators: name: Lechle, Hartwig
Publisher: name: Forum Classicum
Year: 2017

description: -
description: Forum Classicum, Nr. 1 (1998): Forum Classicum
[Gymnasium 104, 1997, Heft 6 / Kunst + Unterricht Heft 209/1997 / Blick in die Wissenschaft (6, 1997, Heft 9)…]
Creators: name: Rabl, Josef
Publisher: name: Forum Classicum
Year: 2017

description: -
description: Forum Classicum, Nr. 1 (1998): Forum Classicum
[Gymnasium 105, 1998, H. 2 / Hermes 126, 1998, H. 1 / Historia 47, 1998, H. 1 …]
Creators: name: Mensching, Eckart
Publisher: name: Forum Classicum
Year: 2017

description: -
description: Forum Classicum, Nr. 2 (1998): Forum Classicum
Modellbasierte Entwurfsmethodik für drahtlose Sensorknoten
Creators: name: Hesse, Marc
Publisher: name: Universität Bielefeld
Year: 2021
Subjects: subject: 000

description: Die stetig steigende Komplexität von eingebetteten mikroelektronischen Systemen, die sich durch eine Vielzahl von Komponenten mit jeweils verschiedenen möglichen Zustände jeder einzelnen Komponente auszeichnet, führt dazu, dass eine ganzheitliche Optimierung nicht mehr, oder nur sehr zeitaufwändig möglich ist. Dieses zeigt sich auch im Bereich der drahtlosen Sensorknoten, welche sich durch mehrere Sensoren, ein Bauteil zur Informationsverarbeitung, eine Funkschnittstelle und eine Energieversorgung mittels Batterie auszeichnen. Dessen Optimierung besteht in der Maximierung der Energieeffizienz, welche als die Anpassung der Leistungsfähigkeit an die Anforderungen der Anwendung bei gleichzeitiger Minimierung der Leistungsaufnahme definiert ist. Ziel der Arbeit ist daher die Entwicklung einer Entwurfsmethodik für drahtlose Sensorknoten, welche sowohl die Energieeffizienz des Systems optimiert, als auch den Entwurfsprozess systematisiert. Einleitend wird zunächst der Stand der Technik drahtloser Sensorknoten hinsichtlich Systemstruktur, Komponenten, Messgrößen und Parametern sowie der verfügbaren Systeme analysiert. Anschließend wird die bisher übliche Methodik zur Messung der Leistungsaufnahme von eingebetteten Systemen dargestellt und das Vorgehen anhand von zwei Praxisbeispielen verdeutlicht, wodurch sich die Komplexität der Konfigurationsmöglichkeiten hinsichtlich der Optimierung bestätigt. Vergleichend dazu wird der Stand der Technik für die Modellierung von drahtlosen Sensorknoten analysiert. Auf dieser Grundlage wird die Methodik für den Entwurf von drahtlosen Sensorknoten beschrieben. Zunächst erfolgt die Einordnung in den bisherigen Entwurfsprozess drahtloser Sensorknoten und im Anschluss daran die Ableitung des Handlungsbedarfs. Darauf folgt die theoretische Betrachtung des aufgestellten Modells anhand des grundlegenden Systemund Komponentenmodells. Anschließend werden die spezifischen Modelle für die einzelnen Komponenten und deren Zusammenschluss zu einem Modell für das Gesamtsystem beschrieben. Darauf aufbauend wird das Systemverhalten mittels der Definition von Tasks, dem Tastgrad und dem Datenfluss abgebildet. Somit wird eine Entwurfsraumexploration hinsichtlich Leistungsfähigkeit und Leistungsaufnahme ermöglicht. Anschließend wird die Methodik des modellgestützten Entwurfs von drahtlosen Sensorknoten exemplarisch angewendet, wobei der Entwurfsraum in jedem Schritt des Entwurfsprozesses eingeschränkt und schlussendlich auf einen kleinen Lösungsraum fokussiert wird. Somit wird demonstriert, dass das Verfahren in der Lage ist, den Entwurf zu systematisieren und durch die Simulation der verschiedenen Entwurfsschritte zielführender zu gestalten. Das Vorgehen erhöht somit zum einen die Effizienz des Sensorknotens und zum anderen die Effizienz der Entwicklung von drahtlosen Sensorknoten oder auch eingebetteten Systemen im weiteren Sinne.
Precursors of order in aggregates of patchy particles
Creators: name: Vasilyev, Oleg A.
name: Klumov, Boris A.
name: Tkachenko, Alexei V.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We study computationally the local structure of aggregated systems of patchy particles. By calculating the probability distribution functions of various rotational invariants we can identify the precursors of orientation order in amorphous phase. Surprisingly, the strongest signature of local order is observed for 4-patch particles with tetrahedral symmetry, not for 6-patch particles with the cubic one. This trend is exactly opposite to their known ability to crystallize. We relate this anomaly to the observation that a generic aggregate of patchy systems has coordination number close to 4. Our results also suggest a significant correlation between rotational order in the studied liquids with the corresponding crystalline phases, making this approach potentially useful for a broader range of patchy systems.
description: 12 pages, 3 figures