title: Ð¤Ð°ÑÐ¼Ð¾ÐºÐ¸Ð½ÐµÑÐ¸ÐºÐ° Ð°Ð½Ð°Ð»Ð¾Ð³Ð° Ð±Ð¾Ð¼Ð±ÐµÐ·Ð¸Ð½Ð° (AMBA), Ð¼ÐµÑÐµÐ½Ð½Ð¾Ð³Ð¾ 68Ga, 177Lu, Ñ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ñ ÑÐ°ÐºÐ¾Ð¼ Ð¿ÑÐµÐ´ÑÑÐ°ÑÐµÐ»ÑÐ½Ð¾Ð¹ Ð¶ÐµÐ»ÐµÐ·Ñ Ð´Ð»Ñ Ð¾ÑÐµÐ½ÐºÐ¸ Ð¿Ð¾Ð³Ð»Ð¾ÑÐµÐ½Ð½ÑÑ Ð´Ð¾Ð· Ð² Ð¾ÑÐ³Ð°Ð½Ð°Ñ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Pharmokinetics of analogue of bombesin (AMBA) labeled with 68Ga, 177Lu in patients with prostate cancer for assessment of absorbed doses in organs
Creators: name: ÐÐ¾ÑÑÐ½Ð¾Ð², ÐÑÑÑÐ¼
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2021
Subjects: ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ð½Ð°Ñ Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÐºÐ°
ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ð½Ð°Ñ ÑÐµÑÐ°Ð¿Ð¸Ñ
68GA
177LU
Ð±Ð¾Ð¼Ð±ÐµÐ·Ð¸Ð½
amba
Ð¿Ð¾Ð³Ð»Ð¾ÑÑÐ½Ð½ÑÐµ Ð´Ð¾Ð·Ñ
ÑÑÑÐµÐºÑÐ¸Ð²Ð½ÑÐµ Ð´Ð¾Ð·Ñ
radionuclide diagnostics
radionuclide therapy
bombesin
absorbed doses
effective doses

description: Ð ÑÐ°Ð±Ð¾ÑÐµ Ð±ÑÐ» Ð¿ÑÐ¾Ð¸Ð·Ð²ÐµÐ´ÐµÐ½ ÑÐ°ÑÑÐµÑ Ð½Ð°ÐºÐ¾Ð¿Ð»ÐµÐ½Ð½Ð¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð Ð¤Ð Ð´Ð»Ñ Ð¸Ð½ÑÐµÑÐµÑÑÑÑÐ¸Ñ Ð¾ÑÐ³Ð°Ð½Ð¾Ð² Ñ Ð¼ÑÑÐµÐ¹ Ð¸Ð»Ð¸ ÐºÑÑÑ Ð² Ð²Ð¸Ð´Ðµ Ð²Ð²ÐµÐ´ÐµÐ½Ð½Ð¾Ð¹ Ð´Ð¾Ð·Ñ(ID) Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÑ Ð´Ð°Ð½Ð½ÑÑ, Ð° ÑÐ°ÐºÐ¶Ðµ Ð´Ð°Ð½Ð½ÑÑ Ð²Ð·ÑÑÑÑ Ð¸Ð· Ð½Ð°ÑÑÐ½Ð¾Ð¹ ÑÑÐ°ÑÑÐ¸, Ð¿ÑÐ¸ Ð¿Ð¾Ð¼Ð¾ÑÐ¸ Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½Ð¾ÑÑÐµÐ¹ MS Excel. ÐÐ° Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð¸Ð¸ ÑÑÐ¸Ñ Ð´Ð°Ð½Ð½ÑÑ, Ð½Ð° Ð±Ð°Ð·Ðµ Ð±Ð¸Ð±Ð»Ð¸Ð¾ÑÐµÐºÐ¸ ÑÐ·ÑÐºÐ° python matplotplit.pyplot Ð±ÑÐ»Ð¸ Ð¿Ð¾ÑÑÑÐ¾ÐµÐ½Ñ Ð°Ð¿Ð¿ÑÐ¾ÐºÑÐ¸Ð¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐµ ÐºÑÐ¸Ð²ÑÐµ Ð½Ð°ÐºÐ¾Ð¿Ð»ÐµÐ½Ð¸Ñ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ° Ð¸ ÑÐ°ÑÑÑÐ¸ÑÐ°Ð½Ñ Ð¸Ð½ÑÐµÐ³ÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐµ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸, ÐºÐ¾ÑÐ¾ÑÑÐµ Ð¿Ð¾ÑÐ»Ðµ Ð±ÑÐ»Ð¸ Ð¿ÐµÑÐµÐ²ÐµÐ´ÐµÐ½Ñ Ðº ÑÐ°ÐºÐ¾Ð²ÑÐ¼ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑÐ¼ Ñ ÑÐµÐ»Ð¾Ð²ÐµÐºÐ° Ð² Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ðµ MS Excel. ÐÐ¾ÑÐ»Ðµ Ð¿ÐµÑÐµÐ²Ð¾Ð´Ð° Ð¸Ð½ÑÐµÐ³ÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÑ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐµÐ¹ Ð² Ð¾ÑÐ³Ð°Ð½Ð°Ñ Ð¼ÑÑÐµÐ¹ Ð¸Ð»Ð¸ ÐºÑÑÑ Ð² Ð¸Ð½ÑÐµÐ³ÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐµ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð² Ð¾ÑÐ³Ð°Ð½Ð°Ñ ÑÐµÐ»Ð¾Ð²ÐµÐºÐ° Ð¾Ð½Ð¸ Ð±ÑÐ»Ð¸ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ñ Ð² Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ðµ IDAC-Dose 2.1 Ð´Ð»Ñ ÑÐ°ÑÑÐµÑÐ° Ð¿Ð¾Ð³Ð»Ð¾ÑÑÐ½Ð½ÑÑ Ð´Ð¾Ð· Ð² Ð¾ÑÐ³Ð°Ð½Ð°Ñ Ð¸ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾Ð¹ Ð´Ð¾Ð·Ñ Ð´Ð»Ñ ÑÐ°Ð½ÑÐ¾Ð¼Ð¾Ð² Ð²Ð·ÑÐ¾ÑÐ»Ð¾Ð³Ð¾ Ð¼ÑÐ¶ÑÐ¸Ð½Ñ Ð¸ Ð²Ð·ÑÐ¾ÑÐ»Ð¾Ð¹ Ð¶ÐµÐ½ÑÐ¸Ð½Ñ. ÐÑÐ»Ð¾ Ð²ÑÑÐ²Ð»ÐµÐ½Ð¾, ÑÑÐ¾ Ð¿ÑÐ¾Ð´ÑÐºÑÐ°Ð¼Ð¸ ÑÐ°ÑÐ¿Ð°Ð´Ð° 68Ga Ð¸ 177Lu Ð½Ðµ Ð²Ð½Ð¾ÑÑÑ ÑÐ²Ð¾Ð¹ Ð²ÐºÐ»Ð°Ð´ Ð² Ð±Ð¸Ð¾ÑÐ°ÑÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ðµ, ÑÐ°Ðº ÐºÐ°Ðº Ð¾Ð±Ð° ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ð° ÑÑÐ°Ð·Ñ Ð¶Ðµ ÑÐ°ÑÐ¿Ð°Ð´Ð°ÑÑÑÑ Ð´Ð¾ ÑÑÐ°Ð±Ð¸Ð»ÑÐ½ÑÑ Ð¸Ð·Ð¾ÑÐ¾Ð¿Ð¾Ð² ÑÐ¸ÑÐºÐ¾Ð½Ð¸Ñ-68 Ð¸ Ð³Ð°ÑÐ½Ð¸Ñ-177 ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²ÐµÐ½Ð½Ð¾. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ Ð·Ð½Ð°ÑÐµÐ½Ð¸Ñ Ð¿Ð¾Ð³Ð»Ð¾ÑÑÐ½Ð½ÑÑ Ð´Ð¾Ð· ÑÐºÐ°Ð·ÑÐ²Ð°ÑÑ Ð½Ð° ÑÐ¾, Ð² ÐºÐ°ÐºÐ¸Ñ Ð¾ÑÐ³Ð°Ð½Ð°Ñ ÑÐ°Ð´Ð¸Ð¾Ð½ÑÐºÐ»Ð¸Ð´Ñ Ð·Ð°Ð´ÐµÑÐ¶Ð¸Ð²Ð°ÑÑÑÑ Ð±Ð¾Ð»ÑÑÐµ Ð²ÑÐµÐ³Ð¾ Ð¸ Ð² ÑÐµÐ»Ð¾Ð¼ ÑÐ¾Ð²Ð¿Ð°Ð´Ð°ÑÑ Ñ ÐºÐ°ÑÑÐ¸Ð½Ð¾Ð¹ Ð¼ÐµÑÐ°Ð±Ð¾Ð»Ð¸Ð·Ð¼Ð° Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ°. ÐÐ¾Ð¶Ð½Ð¾ ÑÑÐ¸ÑÐ°ÑÑ, ÑÑÐ¾ Ð·Ð½Ð°ÑÐµÐ½Ð¸Ñ ÑÑÑÐµÐºÑÐ¸Ð²Ð½ÑÑ Ð´Ð¾Ð· Ð¿Ð¾Ð»ÑÑÐ¸Ð»Ð¸ÑÑ Ð½Ð¾ÑÐ¼Ð°Ð»ÑÐ½ÑÐ¼Ð¸, Ð¸Ñ Ð¼Ð¾Ð¶Ð½Ð¾ Ð¾ÑÐ½ÐµÑÑÐ¸ Ðº Ð¾ÑÐµÐ½Ñ Ð½Ð¸Ð·ÐºÐ¾Ð¼Ñ ÑÐ°Ð´Ð¸Ð°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¼Ñ ÑÐ¸ÑÐºÑ, Ð¾Ð´Ð½Ð°ÐºÐ¾, Ð½ÐµÐ¾Ð±ÑÐ¾Ð´Ð¸Ð¼Ð¾ ÑÑÐ¸ÑÑÐ²Ð°ÑÑ ÑÑÐ¾ Ð½ÐµÑ ÑÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð½ÑÑ Ð½Ð¾ÑÐ¼ Ð¸ ÐºÑÐ¸ÑÐµÑÐ¸ÐµÐ² Ð´Ð»Ñ Ð¸Ñ Ð¾ÑÐµÐ½ÐºÐ¸ Ð¿ÑÐ¸ Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÐºÐµ Ð¸ ÑÐµÑÐ°Ð¿Ð¸Ð¸, Ð¿Ð¾ÑÑÐ¾Ð¼Ñ Ð¸Ñ Ð¾Ð±ÑÐ°Ñ Ð¾ÑÐµÐ½ÐºÐ° ÑÑÐ°Ð½Ð¾Ð²Ð¸ÑÑÑ Ð·Ð°ÑÑÑÐ´Ð½Ð¸ÑÐµÐ»ÑÐ½Ð¾Ð¹ Ð¸ Ð¿Ð¾ÑÐ²Ð»ÑÐµÑÑÑ Ð½ÐµÐ¾Ð±ÑÐ¾Ð´Ð¸Ð¼Ð¾ÑÑÑ Ð² Ð¾Ð¿Ð¸ÑÐ°Ð½Ð¸Ñ Ð¿Ð¾Ð´ÑÐ¾Ð´Ð¾Ð² Ðº Ð´Ð¾Ð·Ð¸Ð¼ÐµÑÑÐ¸Ð¸ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ð¿ÑÐ¸ Ð»ÐµÑÐµÐ½Ð¸Ð¸ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð Ð¤Ð. ÐÑÐ» ÑÐ´ÐµÐ»Ð°Ð½ Ð²ÑÐ²Ð¾Ð´, ÑÑÐ¾ Ð½ÐµÐ¾Ð±ÑÐ¾Ð´Ð¸Ð¼Ð¾ Ð¿ÑÐ¾Ð¸Ð·Ð²ÐµÑÑÐ¸ Ð±Ð¾Ð»ÑÑÐµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¹.
description: In this work, the accumulated activity of radiopharmaceutical for the organs of interest in mice or rats was calculated in the form of an injected dose (ID) using experimental data, as well as data taken from a scientific article, using MS Excel. Based on these data, on the basis of the python library matplotplit.pyplot, approximated curves of drug accumulation were constructed and integrated activity were calculated, which were then converted to such activity in humans in MS Excel. After the translation of the integrated activity in the organs of mice or rats into the integrated activity in the human organs, they were used in the IDAC-Dose 2.1 program to calculate the absorbed doses in organs and the effective dose in an adult male and an adult female phantoms. It was revealed that the decay products of 68Ga and 177Lu do not contribute to biodistribution, since both radionuclides immediately decay to stable isotopes of zirconium-68 and hafnium-177, respectively. The obtained values of absorbed doses indicate in which organs the radionuclides are retained the most and generally coincide with the pattern of drug metabolism. It can be considered that the values of effective doses turned out to be normal, they can be attributed to very low radiation risk, however it is necessary to take into account that there are no established norms and criteria for their assessment in diagnosis and therapy, therefore their overall assessment becomes difficult and there is a need to describe approaches to patient dosimetry when treating patients using radiopharmaceuticals. It was concluded that more research is needed.