Additional file 1 of Traumatic brain injury induces TDP-43 mislocalization and neurodegenerative effects in tissue distal to the primary injury site in a non-transgenic mouse
Creators: name: Bjorklund, George R.
name: Wong, Jennifer
name: Brafman, David
name: Bowser, Robert
name: Stabenfeldt, Sarah E.
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: Additional file 1. Table S1. Analysis of number of NEUN-positive neurons sampled between ipsilateral (injured) and contralateral (non-injured) cortical hemispheres in the unilateral TBI model at all analyzed time points. (SEM=standard error of the mean, p value=statistical significance, t=t-value, df=degrees of freedom, n=number of samples). Table S2. Percent of NEUN-positive neurons sampled that display indications of TDP-43 mislocalization over all time points for injured and naïve age-matched control groups. (SEM=standard error of the mean, n=number of samples). Table S3. Statistical analysis of injured versus naïve age-matched control group comparisons for NEUN-positive neuron counts at each timepoint analyzed. (SEM=standard error of the mean, p value=statistical significance, t=t-value, df=degrees of freedom, n=number of samples). Table S4. Statistical analysis of NEUN positive cells displaying TDP-43 nucleocytoplasmic mislocalization between the ipsilateral and contralateral cortices for all timepoints in injured and naïve controls. (SEM=standard error of the mean, p value=statistical significance, ns=not significant). Table S5. Statistical analysis of all timepoint comparisons between injured and naïve age-matched control groups for total cortical NEUN-positive neurons displaying nuclear TDP-43 mislocalization. (Adjusted p value=statistical significance, t=t-value, df=degrees of freedom, n=number of samples, ns=not significant) (Significance: *p&lt;0.05, **p&lt;0.01, ***p&lt;0.001, ****p&lt;0.0001). Table S6. Statistical analysis of all timepoint comparisons between injured and naïve age-matched control groups for cortical layer 2/3 NEUN-positive neurons displaying nuclear TDP-43 mislocalization. (Adjusted p value=statistical significance, t=t-value, df=degrees of freedom, n=number of samples, ns=not significant) (Significance: *p&lt;0.05, **p&lt;0.01, ***p&lt;0.001, ****p&lt;0.0001). Table S7. Statistical analysis of all timepoint comparisons between injured and naïve age-matched control groups for cortical layer 5 NEUN-positive neurons displaying nuclear TDP-43 mislocalization. (Adjusted p value=statistical significance, t=t-value, df=degrees of freedom, n=number of samples, ns=not significant) (Significance: *p&lt;0.05, **p&lt;0.01, ***p&lt;0.001, ****p&lt;0.0001). Table S8. Statistical analysis of all timepoint comparisons between injured and naïve age-matched control groups for cortical layer 6 NEUN-positive neurons displaying nuclear TDP-43 mislocalization. (Adjusted p value=statistical significance, t=t-value, df=degrees of freedom, n=number of samples) (Significance: *p&lt;0.05, **p&lt;0.01, ***p&lt;0.001, ****p&lt;0.0001). Table S9. Analysis of number of NEUN-positive neurons sampled between ipsilateral and contralateral spinal cord hemispheres in the unilateral TBI model at all analyzed time points. (SEM=standard error of the mean, p value=statistical significance, t=t-value, df=degrees of freedom, n=number of samples). Table S10. Statistical analysis of NEUN positive cells displaying TDP-43 nucleocytoplasmic mislocalization between the ipsilateral and contralateral spinal cord hemispheres for all timepoints in injured and naïve controls. (SEM=standard error of the mean, p value=statistical significance, t=t-value, df=degrees of freedom, n=number of samples, ns=not significant). Table S11. Statistical analysis of all timepoint comparisons between injured and naïve age-matched control groups for total spinal cord NEUN-positive neurons displaying nuclear TDP-43 mislocalization. (Adjusted p value=statistical significance, t=t-value, df=degrees of freedom, n=number of samples).