cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Metazoans and Intrinsic Apoptosis: An Evolutionary Analysis of the Bcl-2 Family
Creators: name: Suraweera, Chathura
name: Banjara, Suresh
name: Hinds, MG
name: Kvansakul, Marc
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 310199
subject: Biochemistry and cell biology not elsewhere classified
classificationCode: 310599
subject: Genetics not elsewhere classified

description: The B-cell lymphoma-2 (Bcl-2) family is a group of genes regulating intrinsic apoptosis, a process controlling events such as development, homeostasis and the innate and adaptive immune responses in metazoans. In higher organisms, Bcl-2 proteins coordinate intrinsic apoptosis through their regulation of the integrity of the mitochondrial outer membrane; this function appears to have originated in the basal metazoans. Bcl-2 genes predate the cnidarian-bilaterian split and have been identified in porifera, placozoans and cnidarians but not ctenophores and some nematodes. The Bcl-2 family is composed of two groups of proteins, one with an α-helical Bcl-2 fold that has been identified in porifera, placozoans, cnidarians, and almost all higher bilaterians. The second group of proteins, the BH3-only group, has little sequence conservation and less well-defined structures and is found in cnidarians and most bilaterians, but not porifera or placozoans. Here we examine the evolutionary relationships between Bcl-2 proteins. We show that the structures of the Bcl-2-fold proteins are highly conserved over evolutionary time. Some metazoans such as the urochordate Oikopleura dioica have lost all Bcl-2 family members. This gene loss indicates that Bcl-2 regulated apoptosis is not an absolute requirement in metazoans, a finding mirrored in recent gene deletion studies in mice. Sequence analysis suggests that at least some Bcl-2 proteins lack the ability to bind BH3-only antagonists and therefore potentially have other non-apoptotic functions. By examining the foundations of the Bcl-2 regulated apoptosis, functional relationships may be clarified that allow us to understand the role of specific Bcl-2 proteins in evolution and disease.
Discovery of a selective and reversible LSD1 inhibitor with potent anticancer effects in vitro and in vivo
Creators: name: Zhang, Xiao-Song
name: Liu, Jin-Zhan
name: Mei, Ying-Ying
name: Zhang, Meng
name: Sun, Li-Wei
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Biochemistry
Cell Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Cancer

description: Lysine-specific demethylase 1 (LSD1) is abnormally overexpressed in various tumour tissues of patients and has been an attractive anticancer target. In this work, a potent LSD1 inhibitor (compound 14) was designed and synthesised by the molecular hybridisation strategy. It displays the potent antiproliferative activity against HepG2, HEP3B, HUH6, and HUH7 cells with IC50 values of 0.93, 2.09, 1.43, and 4.37 μM, respectively. Furthermore, compound 14 is a selective and reversible LSD1 inhibitor with an IC50 value of 0.18 μM and increases the methylation levels of H3K4me1/2. Molecular docking studies showed that it formed hydrogen bonds, hydrophilic interactions and hydrophobic interactions with residues of LSD1. Anticancer mechanisms demonstrated that it suppresses migration and epithelial–mesenchymal transition process in HepG2 cells. Importantly, it exhibits potent anti-liver cancer effects in vivo without obvious toxic effects. These interesting findings suggested that compound 14, a novel LSD1 inhibitor, may be a promising therapeutic agent to treat liver cancer.
Hidden Between the Splices: Unearthing Moving Images of Student Protest in Production Element Reels
Creators: name: Wilcox, Matthew
Publisher: name: unknown
Year: 2022
Subjects: subject: College life films
subject: Student protesters
subject: Archival materials--Conservation and restoration
subject: Sports films
subject: Student movements
subject: Motion pictures

description: Historical filmed recordings of demonstrations may live on reels of production elements. However, film can labels and film leader descriptors may not always provide all the information about the moving image content on its related reel. But when instances such as these are discovered, they may greatly benefit researchers. By creating separate records for these instances in digital repositories, and providing value-added descriptors, emphasis can be placed (and instances are made more accessible) on these moments in history that might have otherwise gone unnoticed to present-day researchers.
Supplemental Material, Appendices - Effectiveness of Digital Health Interventions on Unintentional Injury, Violence, and Suicide: Meta-Analysis
Creators: name: Chen, Mengtong
name: Chan, Ko Ling
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law

description: Supplemental Material, Appendices for Effectiveness of Digital Health Interventions on Unintentional Injury, Violence, and Suicide: Meta-Analysis by Mengtong Chen and Ko Ling Chan in Trauma, Violence, & Abuse
Rolo, José Manuel, Capitalismo, Tecnologia e Dependência em Portugal -Colecção A. S. - Lisboa: Editorial Presença/Gabinete de Investigações Sociais, 1977, 211 p.
Creators: name: Abreu, Orlando C.
Publisher: name: Economia
Year: 1978

description: Economia, Vol 2 No 2 (1978)
Supplementary_data20200916 – Supplemental Material for Psychometric Properties of the Academic Encouragement Scale in Chinese University Students
Creators: name: Tang, Hui
name: Huo, Zhongkai
name: Liu, Chaojie
name: Liu, Zhijun
name: Wong, Y. Joel
Publisher: name: SAGE Journals
Year: 2020
Subjects: Education
Psychology not elsewhere classified

description: Supplemental Material, Supplementary_data20200916 for Psychometric Properties of the Academic Encouragement Scale in Chinese University Students by Hui Tang, Zhongkai Huo, Chaojie Liu, Zhijun Liu and Y. Joel Wong in Journal of Psychoeducational Assessment
Supplemental_Figure_2 – Supplemental material for Canagliflozin impedes ischemic hind-limb recovery in the setting of diabetes
Creators: name: Nalugo, Margaret
name: Harroun, Nikolai
name: Li, Chenglong
name: Belaygorod, Larisa
name: Semenkovich, Clay F
name: Zayed, Mohamed A
Publisher: name: SAGE Journals
Year: 2020
Subjects: Cardiology
Surgery

description: Supplemental material, Supplemental_Figure_2 for Canagliflozin impedes ischemic hind-limb recovery in the setting of diabetes by Margaret Nalugo, Nikolai Harroun, Chenglong Li, Larisa Belaygorod, Clay F Semenkovich and Mohamed A Zayed in Vascular Medicine
A stable GH31 α-glucosidase as a model system for the study of mutations leading to human glycogen storage disease type II
Creators: name: Iacono, Roberta
name: Paragliola, Francesca Maria Pia
name: Strazzulli, Andrea
name: Moracci, Marco
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Cancer
subject: Computational Biology

description: GH31 glycosidases are widespread across organisms, but remarkably, less than 1% of them have been biochemically characterised to date. Among them, human lysosomal acid α-glucosidase (GAA) stands out due to its link to Pompe disease, a rare lysosomal storage disorder caused by its deficiency. This disease results in glycogen accumulation, severe cellular damage, motor impairment, and premature death. Structural and functional studies of GAA mutants are challenging due to their instability and lack of activity, hindering their expression and purification. The GH31 enzyme MalA from a hyperthermophilic archaeon is explored here as a stable homolog of GAA. MalA is highly expressible, easy to purify, and structurally characterised. The R400H mutant in MalA, corresponding to the pathogenic GAA R600H mutation, revealed here a 1200-fold drop in specificity constant and >8 °C reduction in thermal stability. We propose MalA’s as a robust model for studying GAA mutations and developing therapeutic chaperones.
Data Storytelling syllabus - 1 credit Fall Semester 2022
Creators: name: O'Neill, Terence
Publisher: name: unknown
Year: 2023
Subjects: subject: Libraries
subject: Entrepreneurship

description: This is a syllabus, including a link to assignments used, for a 1 credit course "Data Storytelling." The course is developed from work with entrepreneurs and includes elements of Design Thinking and Data Literacy.
To go or not to go? Biological logic gating engineered T cells
Creators: name: Abbott, RC
name: Hughes-Parry, HE
name: Jenkins, Misty
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 321199
subject: Oncology and carcinogenesis not elsewhere classified

description: Genetically engineered T cells have been successfully used in the treatment of hematological malignancies, greatly increasing both progression-free and overall survival in patients. However, the outcomes of patients treated with Chimeric Antigen Receptor (CAR) T cells targeting solid tumors have been disappointing. There is an unmet clinical need for therapies which are specifically designed to overcome the challenges associated with solid tumors such as tumor heterogeneity and antigen escape. Genetic engineering employing the use of biological logic gating in T cells is an emerging and cutting-edge field that may address these issues. The advantages of logic gating include localized secretion of anti-tumor proteins into the tumor microenvironment, multi antigen targeting of tumors and a potential increase in safety when targeting tumor antigens which may not be exclusively tumor specific. In this review, we introduce the concept of biological logic gating and how this technology addresses some of the challenges of current CAR T treatment. We outline the types of logic gating circuits and finally discuss the application of this new technology to engineered T cells, in the treatment of cancer.
Formative Annual Review Planning Worksheet
Creators: name: Schopieray, Scott
Publisher: name: unknown
Year: 2023
Subjects: subject: Career development
subject: Career education
subject: Leadership

description: This worksheet helps to break down Annual Goals into their parts, to identify indicators of success, and the steps to achieve the goals. Breaking your annual goals down into these sub-parts helps you to engage in the formative review process by understanding and documenting your movement toward the bigger goals each year.
Defining timeliness in care for patients with lung cancer: a scoping review
Creators: name: Ansar, Adnan
name: Lewis, Virginia
name: McDonald, CF
name: Liu, Chaojie
name: Rahman, Muhammad
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 420699
subject: Public health not elsewhere classified

description: Objectives Early diagnosis and reducing the time taken to achieve each step of lung cancer care is essential. This scoping review aimed to examine time points and intervals used to measure timeliness and to critically assess how they are defined by existing studies of the care seeking pathway for lung cancer. Methods This scoping review was guided by the methodological framework for scoping reviews by Arksey and O'Malley. MEDLINE, EMBASE, CINAHL and PsycINFO electronic databases were searched for articles published between 1999 and 2019. After duplicate removal, all publications went through title and abstract screening followed by full text review and inclusion of articles in the review against the selection criteria. A narrative synthesis describes the time points, intervals and measurement guidelines used by the included articles. Results A total of 2113 articles were identified from the initial search. Finally, 68 articles were included for data charting process. Eight time points and 14 intervals were identified as the most common events researched by the articles. Eighteen different lung cancer care guidelines were used to benchmark intervals in the included articles; all were developed in Western countries. The British Thoracic Society guideline was the most frequently used guideline (20%). Western guidelines were used by the studies in Asian countries despite differences in the health system structure. Conclusion This review identified substantial variations in definitions of some of the intervals used to describe timeliness of care for lung cancer. The differences in healthcare delivery systems of Asian and Western countries, and between high-income countries and low-income-middle-income countries may suggest different sets of time points and intervals need to be developed.
Natural product as a lead for impairing mitochondrial respiration in cancer cells
Creators: name: Pyrczak-Felczykowska, Agnieszka
name: Kaczorowska, Anna-Karina
name: Giełdoń, Artur
name: Braczko, Alicja
name: Smoleński, Ryszard T.
name: Antosiewicz, Jędrzej
name: Reekie, Tristan A.
name: Herman-Antosiewicz, Anna
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Hematology

description: The impact of the isoxazole derivative of usnic acid, ISOXUS (formerly known as 2b) on cancer and non-cancerous cell metabolism was investigated. ISOXUS significantly reduced the utilisation of most metabolic substrates that produce NADH or FADH2, mitochondrial electron flow and oxygen consumption rate (OCR) in MCF-7 breast cancer cells in contrast to HB2 normal epithelial cells. Molecular docking revealed that ISOXUS inhibits mitochondrial respiratory chain complex II, which was confirmed experimentally. Disturbance of electron flow in MCF-7 cells resulted in increased reactive oxygen species (ROS) production. They appeared crucial for ISOXUS-induced cancer cell vacuolization and a drop in survival as an antioxidant, α-tocopherol, protected against these processes. These findings indicate that ISOXUS is a metabolic inhibitor that targets mitochondrial complex II in breast cancer cells resulting in diminished ATP production and increased ROS formation which translates into reduced cell viability.
sj-pdf-1-lup-10.1177_0961203320966378 - Supplemental material for Improving sensitivity of the connective tissue disease screening questionnaire: A comparative study of various scoring methods
Creators: name: Xiang, Ling
name: Low, Andrea Hsiu Ling
name: Leung, Ying Ying
name: Fong, Warren
name: Mihir Gandhi
name: Xiaohui Xin
name: Uy, Elenore JB
name: Sparks, Jeffrey A
name: Karlson, Elizabeth W
name: Thumboo, Julian
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111702 Aged Health Care
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-1-lup-10.1177_0961203320966378 for Improving sensitivity of the connective tissue disease screening questionnaire: A comparative study of various scoring methods by Ling Xiang, Andrea Hsiu Ling Low, Ying Ying Leung, Warren Fong, Mihir Gandhi, Xiaohui Xin, Elenore JB Uy, Jeffrey A Sparks, Elizabeth W Karlson and Julian Thumboo in Lupus
Profiling and cheminformatics bioprospection of curcurbitacin I and momordin Ic from Momordica balsamina on α-amylase and α-glucosidase
Creators: name: Jaichand, Viruska
name: Lanrewaju, Adedayo Ayodeji
name: Baijnath, Himansu
name: Sabiu, Saheed
name: Mohanlall, Viresh
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Momordica spp. has been traditionally used to manage type 2 diabetes mellitus, but the mechanisms and metabolites remain unclear. This study evaluated the inhibitory potential of Momordica balsamina extracts on α-amylase and α-glucosidase in vitro, identifying cucurbitacin I and momordin Ic via high-performance liquid chromatography-photo diode array, and their inhibitory potential in silico. Ethyl acetate seed extract (14.46 µg/ml) and hexane fruit flesh extract (16.79 µg/ml) exhibited lower IC50 values against α-amylase and α-glucosidase, respectively, compared to acarbose (reference standard). Comparatively, momordin Ic concentrations (36.57–605.98 µg/ml) were higher than cucurbitacin I (17.08–44.34 µg/ml). A 140 ns simulation showed that cucurbitacin I (−63.06 kcal/mol) and momordin Ic (−66.53 kcal/mol) exhibited stronger binding to α-amylase than acarbose (−36.46 kcal/mol), whereas cucurbitacin I (−38.08 kcal/mol) and momordin Ic (−54.87 kcal/mol) displayed weaker binding to α-glucosidase, relative to acarbose (−63.73 kcal/mol). Generally, momordin Ic demonstrated better thermodynamic properties, hence further in vitro and in vivo studies are needed to validate their antidiabetic potential.
Throw Out the Honey, Bring Out the Catfish: Examining the Effectiveness of Calliphoridae (Diptera) Bait (Poster)
Creators: name: Alexander, Paige
Publisher: name: unknown
Year: 2023

description: There is significant variation in the distribution of Diptera (true flies) that contribute to decomposition and are of forensic importance. In an effort to study this distribution, it is necessary to attract these species of dipteran via an artificial trapping method. However, there is no definitive answer to the bait that should be used to collect the greatest quantity of Diptera of forensic importance or the richest diversity. To understand the differences in baits for Diptera traps three butterfly traps were placed in three different areas of the USDA-ARS property in Kerrville, Texas. Traps were set in the morning and were baited with the same bait. They were then collected at the end of the day. The contents of the traps were then frozen and later identified. The specific baits used were beef liver and catfish filets. Diptera were collected off of road kill, and compared. This was done three times a week for six weeks in June through July. Eight calliphoridae species were collected, including Cochiomyia macellaria, Lucilia mexicana, and Chrysomya rufifacies. In total, 697 dipterans were collected, 588 from fish-baited traps, nine from liver-baited traps, and 100 from roadkill.
“Juristen, böse Christen (?)”. Religione e deontologia forense nella teoria del diritto
Creators: name: Romeo, Andrea
Publisher: name: Università degli Studi di Milano
Year: 2017
Subjects: Diritto ecclesiastico

description: Contributo sottoposto a valutazione
SOMMARIO: 1. “Religious lawyering”: la lotta per un movimento accademico – 2. Il possibile ruolo della religione nella deontologia forense – 3. Le critiche della concezione tradizionale e l’idea della morale di ruolo – 4. Problemi teologici di traduzione in forma deontologica – 5. Argomenti religiosi e dibattito pubblico di legal ethics.

“Juristen, böse Christen (?)”. Religion and Legal Ethics in the Theory of Law.
ABSTRACT: This article focus on the question of whether religious studies contribute to legal ethics and professional lawyer’s life. Notoriously, religion's role in legal ethics is difficult to define, also because many scholars, belonging to the standard dominant view, disagree about the same nature of legal ethics concepts. Beginning in the late 1970s and especially during the 1990s, the emerging religious lawyering movement started to analyzes whether and how religion values could be integrated into day-to-day law practice. Today, this academic movement challenges the morality-role idea and try to claim a public dimension for the religious commitment.
description: Stato, Chiese e pluralismo confessionale, 2017: 13 marzo
Intra-individual variability in cognitive performance predicts functional decline in Parkinson’s disease
Creators: name: Davis, Jeremy J.
name: Sivaramakrishnan, Anjali
name: Rolin, Summer
name: Subramanian, Sandeep
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Mental Health
subject: Computational Biology

description: Cognitive deficits contribute to disability in Parkinson’s disease (PD). Cognitive intra-individual variability (IIV) is associated with cognitive decline in age-related disorders, but IIV has not been related to functional ability in PD. We examined IIV in predicting functional ability in participants with PD. De-identified National Alzheimer’s Coordinating Center data (N = 1,228) from baseline and follow-up visits included participants with PD propensity score matched to control participants at baseline on age (M = 72), education (M = 15), and gender (28% female). PD symptom duration averaged 6 years. Outcome measures included the Functional Ability Questionnaire (FAQ), overall test battery mean (OTBM) of ten cognitive variables, IIV calculated as the standard deviation of cognitive data for each participant, Geriatric Depression Scale (GDS), and Unified PD Rating Scale gait and posture items. Baseline FAQ status in the PD group was predicted using logistic regression with age, education, cognition, GDS, and motor function as predictors. We compared baseline characteristics of PD participants with and without functional impairment at follow up. PD participants showed lower OTBM and greater IIV, GDS, and motor dysfunction than controls (p < .0001). Education, OTBM, IIV, GDS, and gait predicted functional status (77% overall classification; AUC = .84). PD participants with functional impairment at follow up showed significantly lower OTBM and greater IIV, GDS, and motor dysfunction at baseline (p < .001). IIV independently predicts functional status in participants with PD while controlling for other variables. PD participants with functional impairment at follow up showed greater IIV than those without functional impairment at follow up.
Small molecules targeting the eubacterial β-sliding clamp discovered by combined in silico and in vitro screening approaches
Creators: name: Caputo, Alessia
name: Elisi, Gian Marco
name: Levati, Elisabetta
name: Barotti, Giulia
name: Sartini, Sara
name: Wagner, Jerome
name: Burnouf, Dominique Y.
name: Ottonello, Simone
name: Rivara, Silvia
name: Montanini, Barbara
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Antibiotic resistance stands as the foremost post-pandemic threat to public health. The urgent need for new, effective antibacterial treatments is evident. Protein-protein interactions (PPIs), owing to their pivotal role in microbial physiology, emerge as novel and attractive targets. Particularly promising is the α-subunit/β-sliding clamp interaction, crucial for the replicative competence of bacterial DNA polymerase III holoenzyme. Through pharmacophore-based virtual screening, we identified 4,000 candidate small molecule inhibitors targeting the β-clamp binding pocket. Subsequently, these candidates underwent evaluation using the BRET assay in yeast cells. Following this, three hits and 28 analogues were validated via Protein Thermal Shift and competitive ELISA assays. Among them, thiazolo[4,5-d]-pyrimidinedione and benzanilide derivatives exhibited micromolar potency in displacing the β-clamp protein partner and inhibiting DNA replication. This screening campaign unveiled new chemical classes of α/β-clamp PPI disruptors capable of inhibiting DNA polymerase III activity, which lend themselves for further optimisation to improve their antibacterial efficacy.
Supplementary figures from Uniaxial orientation of β-chitin nanofibres used as an organic framework in the scales of a hot vent snail
Creators: name: Isobe, Noriyuki
name: Chen, Chong
name: Daicho, Kazuho
name: Saito, Tsuguyuki
name: Bissessur, Dass
name: Takai, Ken
name: Okada, Satoshi
Publisher: name: The Royal Society
Year: 2022
Subjects: Biochemistry

description: Two-dimensional SAXS, 13C CP/MAS NMR, SEM/EDS of the scales
sj-pdf-2-lup-10.1177_0961203320965707 - Supplemental material for Next stop in the treatment of refractory systemic lupus erythematosus: B-cell targeted combined therapy
Creators: name: Bela, Margarida Matos
name: Espinosa, Gerard
name: Cervera, Ricard
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111702 Aged Health Care
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-2-lup-10.1177_0961203320965707 for Next stop in the treatment of refractory systemic lupus erythematosus: B-cell targeted combined therapy by Margarida Matos Bela, Gerard Espinosa and Ricard Cervera in Lupus
title: Hypochlorous acid inhibits viral replication by interfering with viral protein assembly in non-myeloid cells
Creators: name: Zhu, Zhiyuan
Publisher: name: The University of Edinburgh
Year: 2025
Subjects: subject: Hypochlorous acid (HOCl)
subject: Sodium chloride (NaCl)
subject: Viral replication
subject: Myeloperoxidase (MPO)
subject: Herpes simplex virus type 1 (HSV-1)

description: Hypochlorous acid (HOCl) has antibacterial and antiviral properties and is generated by myeloid cells as an innate immune response with the help of myeloperoxidase (MPO). We have earlier shown that antiviral activity in non-myeloid cells can be augmented by increasing the availability of chloride ions. Here, we show that availability of sodium chloride (NaCl) has a dose-dependent promotion effect on HOCl production in different infected human epithelial cells. The promotion effect starts at an early stage of viral replication and increase over time. This suggests that as an innate antiviral response, cells convert chloride ions into HOCl. This antiviral effect weakens after knockdown of genes of MPO, dual oxidases 1 and 2 (DUOX1 and DUOX2), suggesting these enzymes are involved in intracellular HOCl production in non-myeloid cells. NaCl had no inhibitory effect on the modified foot-and-mouth disease virus (FMDV) replicon which can replicate viral genes without producing any infectious viral particles. Inhibition of herpes simplex virus type 1 (HSV-1) capsid assembly was seen in the presence of NaCl. These results indicate HOCl prevents the assembly of viral proteins without damaging gene expression. HOCl is only detected in the cytoplasm (and not within the nucleus) of HSV-1 infected cells, indicating viral proteins are potentially denatured, resulting in proteins that are unable to assemble correctly. These data give us evidence for the mechanism behind the NaCl mediated antiviral innate immune response in non-myeloid cells. We developed a NaCl-resistant HSV-1 strain by propagating viruses in media with additional NaCl concentrations. A reduced antiviral effect was observed when cells were infected with this specific HSV-1 strain in the presence of NaCl. This suggests our passaging successfully developed mutations related to the NaCl mediated innate antiviral response in HSV-1.
Dalla riconciliazione alla guarigione. Alcune riflessioni sulla confessione come cura animarum nella teologia morale e nel diritto canonico
Creators: name: Tarantino, Daniela
Publisher: name: Università degli Studi di Milano
Year: 2017

description: Il contributo, non sottoposto a valutazione, riproduce, con le opportune aggiunte e le note, il testo della relazione tenuta al II International Congress “Justice, Mercy and Law. From revenge to forgiveness in the History of Law” (Universidad Católica de Murcia, 13-16 dicembre 2016), ed è destinato, nella versione in lingua spagnola, alla pubblicazione negli Atti.
SOMMARIO: 1. La penitenza come guarigione dal peccato. Breve nota storico-giuridica – 2. Il confessore: iudex peccatorum, medicus animarum – 3. Dalla giustizia alla misericordia, dalla conversione al perdono. La Confessione come sacramento della guarigione.
description: Stato, Chiese e pluralismo confessionale, 2017: 13 marzo
Recent and Ongoing Research into Metastatic Osteosarcoma Treatments
Creators: name: Harris, Michael
name: Hawkins, Christine
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 310599
subject: Genetics not elsewhere classified
classificationCode: 319999
subject: Other biological sciences not elsewhere classified
classificationCode: 349999
subject: Other chemical sciences not elsewhere classified

description: The survival rate for metastatic osteosarcoma has not improved for several decades, since the introduction and refinement of chemotherapy as a treatment in addition to surgery. Over two thirds of metastatic osteosarcoma patients, many of whom are children or adolescents, fail to exhibit durable responses and succumb to their disease. Concerted efforts have been made to increase survival rates through identification of candidate therapies via animal studies and early phase trials of novel treatments, but unfortunately, this work has produced negligible improvements to the survival rate for metastatic osteosarcoma patients. This review summarizes data from clinical trials of metastatic osteosarcoma therapies as well as pre-clinical studies that report efficacy of novel drugs against metastatic osteosarcoma in vivo. Considerations regarding the design of animal studies and clinical trials to improve survival outcomes for metastatic osteosarcoma patients are also discussed.
Swedish normative data and longitudinal effects of aging for older adults: The Boston Naming Test 30-item and a short version of the Token Test
Creators: name: Fällman, Katarina
name: Wressle, Ewa
name: Marcusson, Jan
name: Classon, Elisabet
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Naming ability and verbal comprehension are cognitive functions that may be affected both by normal aging and by disease. Neuropsychological testing is crucial to evaluate changes in language ability and reliable normative data for all ages are needed. We present clinically useful test norms, together with subsample analysis of longitudinal effects of aging, for two robust and well-known tests that evaluate naming ability and verbal comprehension where the present norms for older adults (aged 85 and older) are sparse or missing. Participants (n = 338) from a Swedish population-based study, the Elderly in Linköping Screening Assessment, were cognitively evaluated with a cognitive screening battery at the age of 85 years and followed to the age of 93 years. Normative data at age 85 years were calculated from a sample (n = 207) that was determined as cognitively healthy after application of rigorous exclusion criteria. Effects of normal aging were investigated by analyzing follow-up performance at age 90 and 93 years for the subsample of cognitively healthy that completed the entire study. The evaluated tests in this study are Swedish versions of the Boston Naming Test 30-item Odd Version (BNT-30) and a short form of the Token Test, Part V (TokV). Analyzes of effects of aging showed that performance decreased with age for BNT-30, but not for TokV. Higher education was associated with better performance in both tests and men performed better than women on the BNT-30. Results also showed naming ability to be more sensitive to aging than verbal comprehension.
sj-pdf-1-jcb-10.1177_0271678X20964344 - Supplemental material for Profiling cerebrovascular function in migraine: A systematic review and meta-analysis
Creators: name: Jemima SA Dzator
name: Howe, Peter RC
name: Wong, Rachel HX
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110305 Emergency Medicine
subject: FOS: Clinical medicine
subject: 110306 Endocrinology
subject: Medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: 110320 Radiology and Organ Imaging
subject: Cell Biology
subject: Biochemistry
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Neuroscience

description: Supplemental material, sj-pdf-1-jcb-10.1177_0271678X20964344 for Profiling cerebrovascular function in migraine: A systematic review and meta-analysis by Jemima SA Dzator, Peter RC Howe and Rachel HX Wong in Journal of Cerebral Blood Flow & Metabolism
What it Takes: Learning From the Experiences of Women in Academic Leadership
Creators: name: Alexander, Paige
Publisher: name: unknown
Year: 2023

description: The academy has contributed to centuries of marginalization and oppression of women throughout various disciplinary fields (e.g., natural or social sciences). Historically, the marginalization took the form of limited opportunity and access to education. To improve equitable access, young women are being mentored into STEM fields, yet the gender distribution is still heavily skewed towards men, particularly in universities. In fact, "women are less likely to maintain their positions long term or to be promoted to higher levels within academia." (Krebsbach, 2022, p. 1). While it is true that women make up just under half of faculty in higher education (49.6%), the gender imbalance at the upper ranks is striking. Women make up approximately a quarter of the distribution at the professor rank in research-intensive institutions, and only 14% of presidents, provosts, and chancellors (Krebsbach, 2022). Women are overall less likely to succeed in higher education and often leave the field altogether. As a woman looking to enter this field, I was inspired to investigate the academic experiences of two deans who identify as women in higher education at research-intensive institutions.
Additional file 1 of Evaluating the accessibility and value of U.S. ambulatory care among Medicaid expansion states and non-expansion states, 2012–2015
Creators: name: Parzuchowski, Aaron
name: Oronce, Carlos
name: Guo, Rong
name: Tseng, Chi-Hong
name: Fendrick, A. Mark
name: Mafi, John N.
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1.
Discovery and biological evaluation of a novel and highly potent JAK2 inhibitor for the treatment of triple negative breast cancer
Creators: name: Miao, Yingxiang
name: Yang, Shudan
name: Zhang, Fang
name: Li, Jindong
name: Zhang, Yan
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Janus kinase 2 (JAK2) is considered an attractive target for the treatment of triple-negative breast cancer (TNBC). Herein, we discovered six JAK2 inhibitors using structure-based virtual screening and molecular docking. Among them, JNN-5 was the best compound. It indicated strong inhibitory effects on JAK2 in the nanomolar range (IC50 = 0.41 ± 0.03 nM), and high selectivity for JAK2 over JAK1 and JAK3 (selectivity index (SI) > 73.17). Moreover, molecular dynamics (MD) simulation exhibited that JNN-5 bound with high stability to JAK2 JH1. Cellular assays revealed that JNN-5 displayed strong antiproliferative activities in the TNBC cell lines (MDA-MB-468, MDA-MB-213, HCC70, MDA-MB-157). JNN-5 significantly reduced the migration of HUVECs with the dose-dependence. JNN-5 had a significant inhibitory effect on multidrug-resistant MDA-MB-231/ADR (IC50 = 0.37 ± 0.02 μM). These data demonstrate that JNN-5 may be a highly effective and selective antitumor compound for the treatment of TNBC.
A Machine-Learning-Based Risk-Prediction Tool for HIV and Sexually Transmitted Infections Acquisition over the Next 12 Months
Creators: name: Xu, X
name: Ge, Z
name: Chow, EPF
name: Yu, Z
name: Lee, D
name: Wu, Jinrong
name: Ong, JJ
name: Fairley, CK
name: Zhang, L
Publisher: name: La Trobe
Year: 2022
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences

description: Background: More than one million people acquire sexually transmitted infections (STIs) every day globally. It is possible that predicting an individual’s future risk of HIV/STIs could contribute to behaviour change or improve testing. We developed a series of machine learning models and a subsequent risk-prediction tool for predicting the risk of HIV/STIs over the next 12 months. Methods: Our data included individuals who were re-tested at the clinic for HIV (65,043 consultations), syphilis (56,889 consultations), gonorrhoea (60,598 consultations), and chlamydia (63,529 consultations) after initial consultations at the largest public sexual health centre in Melbourne from 2 March 2015 to 31 December 2019. We used the receiver operating characteristic (AUC) curve to evaluate the model’s performance. The HIV/STI risk-prediction tool was delivered via a web application. Results: Our risk-prediction tool had an acceptable performance on the testing datasets for predicting HIV (AUC = 0.72), syphilis (AUC = 0.75), gonorrhoea (AUC = 0.73), and chlamydia (AUC = 0.67) acquisition. Conclusions: Using machine learning techniques, our risk-prediction tool has acceptable reliability in predicting HIV/STI acquisition over the next 12 months. This tool may be used on clinic websites or digital health platforms to form part of an intervention tool to increase testing or reduce future HIV/STI risk.
Psote, Apa Psote, bishop of Psoi/Ptolemais (Upper Egypt) and martyr under Diocletian
Creators: name: Admin, CSLA
Publisher: name: University of Oxford
Year: 2017
Subjects: History

description: All evidence related to Psote, Apa Psote, bishop of Psoi/Ptolemais (Upper Egypt) and martyr under Diocletian.
A New Age for Justice: Discovering the Factors that Contribute to Inequity in Secondary Education
Creators: name: Alexander, Paige
Publisher: name: unknown
Year: 2022

description: The overarching purpose of this poster is to explore the extent to which secondary education is equitable. Central to education equity are notions of justice and fairness of access and opportunity across diverse groups. Education is equitable when "all students receive the resources they need so they graduate prepared for success after high school" (Center for Public Education, 2016, p. 1).
Pyridine indole hybrids as novel potent CYP17A1 inhibitors
Creators: name: Wróbel, Tomasz M.
name: Grudzińska, Angelika
name: Yakubu, Jibira
name: du Toit, Therina
name: Sharma, Katyayani
name: Harrington, Jeremiah C.
name: Björkling, Fredrik
name: Jørgensen, Flemming Steen
name: Pandey, Amit V.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Prostate cancer (PCa) is one of the most prevalent malignancies affecting men worldwide, and androgen deprivation therapy (ADT) is a primary treatment approach. CYP17A1 inhibitors like abiraterone target the steroidogenic pathway to reduce androgen levels, but their clinical efficacy is limited by drug resistance and adverse effects. This study reports the synthesis and evaluation of novel CYP17A1 inhibitors derived from a previously identified hit compound. Several analogs were synthesised, including an unexpected di-cyano derivative, which demonstrated increased potency against CYP17A1 compared to abiraterone. Biological assays revealed that these compounds significantly inhibited CYP17A1 enzymatic activity and altered steroid biosynthesis. Among the newly synthesised inhibitors, compound 11 showed the highest potency (IC50 = 4 nM) and the related compound 14 presented a template for further development. A combined docking and molecular dynamics approach was used to identify the possible target binding modes of the compounds.
sj-pdf-2-jcb-10.1177_0271678X20964344 - Supplemental material for Profiling cerebrovascular function in migraine: A systematic review and meta-analysis
Creators: name: Jemima SA Dzator
name: Howe, Peter RC
name: Wong, Rachel HX
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110305 Emergency Medicine
subject: FOS: Clinical medicine
subject: 110306 Endocrinology
subject: Medicine
subject: 110904 Neurology and Neuromuscular Diseases
subject: 110320 Radiology and Organ Imaging
subject: Cell Biology
subject: Biochemistry
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Neuroscience

description: Supplemental material, sj-pdf-2-jcb-10.1177_0271678X20964344 for Profiling cerebrovascular function in migraine: A systematic review and meta-analysis by Jemima SA Dzator, Peter RC Howe and Rachel HX Wong in Journal of Cerebral Blood Flow & Metabolism
Application of machine learning techniques for dementia severity prediction from psychometric tests in the elderly population
Creators: name: Calderón, Carlos
name: Bekios-Calfa, Juan
name: Bekios-Canales, Nikolás
name: Véliz-García, Oscar
name: Beyle, Christian
name: Palominos, Diego
name: Ávalos-Tejeda, Marcelo
name: Domic-Siede, Marcos
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Medicine
Neuroscience
Biological Sciences not elsewhere classified
Mental Health

description: Previous research has shown the benefits of early detection and treatment of dementia. This detection is usually performed manually by one or more clinicians based on reports and psychometric testing. Machine learning algorithms provide an alternative method of prediction that may contribute, with an automated process and insights, to the diagnosis and classification of the severity level of dementia. The aim of this study is to explore the use of neuropsychological data from a reduced version of the Addenbrooke’s Cognitive Examination III (ACE-III) to predict absence or different levels of dementia severity using the Global Deterioration Scale (GDS) scores through the implementation of the kNN machine learning algorithm. A sample of 1164 elderly people over sixty years old were evaluated using a reduced version of the ACE-III and the GDS. The kNN classifier provided good accuracies using 15 items from the ACE-III and adequately differentiating people with absence and mild impairment, from those with more severe levels of impairment according to the GDS rating. Our results suggest that the kNN algorithm may be used to automate aspects of clinical cognitive impairment classification in the elderly population.
PRISMA_2009_checklist_v1 – Supplemental material for The endoscopic predictors of Helicobacter pylori status: a meta-analysis of diagnostic performance
Creators: name: Glover, Ben
name: Teare, Julian
name: Hutan Ashrafian
name: Patel, Nisha
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110306 Endocrinology
subject: FOS: Clinical medicine

description: Supplemental material, PRISMA_2009_checklist_v1 for The endoscopic predictors of Helicobacter pylori status: a meta-analysis of diagnostic performance by Ben Glover, Julian Teare, Hutan Ashrafian and Nisha Patel in Therapeutic Advances in Gastrointestinal Endoscopy
Learning from the Experts On-Site: A Short Term Digital Humanities Study Abroad Framework
Creators: name: Mapes, Kristen
Publisher: name: unknown
Year: 2023
Subjects: subject: Foreign study
subject: Digital humanities
subject: Teaching
subject: Museums--Study and teaching (Higher)

description: This poster presents a digital humanities study abroad program that brings undergraduate students to the UK to explore the intersections of technology, humanities, and the arts. Over four weeks, the students meet with curators, DH practitioners, and creatives. In addition to connecting students with professionals in the cultural heritage sector, the program challenges students to create small-scale digital humanities projects.
sj-pdf-1-eth-10.1177_1466138120967039 - Supplemental material for Critique of podcasting as an anthropological method
Creators: name: Cook, Ian M
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: Anthropology
subject: FOS: Sociology
subject: Sociology

description: Supplemental material, sj-pdf-1-eth-10.1177_1466138120967039 for Critique of podcasting as an anthropological method by Ian M Cook in Ethnography
JAG_supplement_2nd_revision – Supplemental material for Association Between Informant-Reported Sleep Disturbance and Incident Dementia: An Analysis of the National Alzheimer’s Coordinating Center Uniform Data Set
Creators: name: Woojung Lee
name: Gray, Shelly L.
name: Barthold, Douglas
name: Maust, Donovan T.
name: Marcum, Zachary A.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: 110308 Geriatrics and Gerontology
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, JAG_supplement_2nd_revision for Association Between Informant-Reported Sleep Disturbance and Incident Dementia: An Analysis of the National Alzheimer’s Coordinating Center Uniform Data Set by Woojung Lee, Shelly L. Gray, Douglas Barthold, Donovan T. Maust and Zachary A. Marcum in Journal of Applied Gerontology