cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Theory of Reasoned Action as a predictor of environmental behavior: A cross-cultural comparison between college students from Texas, Louisiana, and Honduras
Creators: name: Jaramillo, Pablo Lamiño
name: Tábora-Sarmiento, Shisbeth
name: Millares-Forno, Carla
name: Boren-Alpízar, Amy E.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Plant Biology

description: Environmental and ecological degradation has raised concerns worldwide. Negative attitudes toward the environment plus disinterest have led to improper behavior, influencing climate change and global warming. Awareness could have a positive environmental impact by influencing attitudes and behaviors. One way to generate awareness and ensure positive behavior is through education. Using the Theory of Reasoned Action (TRA), a 33-questions survey was implemented to college students from Texas, Louisiana, and Honduras to (1) compare students’ environmental attitudes, behaviors, and subjective norms at the three universities; and (2) predict how much of the undergraduate students’ environmental behavior variance could be explained by their environmental attitude, subjective norms, and perceived environmental knowledge. Multivariate analysis of variance and hierarchical regressions were performed to address the objectives, respectively. Results showed that Honduras and Louisiana students’ environmental attitudes, behavior, and subjective norms are significantly different than Texas students, and TRA variables increased the prediction of behavior variance by 15%. Understanding interactions between behavior, attitude, knowledge, and subjective norms among college students from different universities may help assess environmental interventions and design successful programs based on group needs.
Effects of Auto-Servo Ventilation on Patients with Sleep-Disordered Breathing, Stable Systolic Heart Failure and Concomitant Diastolic Dysfunction: Subanalysis of a Randomized Controlled Trial
Creators: name: Birner, Christoph
name: Series, Frederic
name: Lewis, Keir
name: Benjamin, Amit
name: Wunderlich, Silke
name: Escourrou, P.
name: Zeman, Florian
name: Luigart, Ruth
name: Pfeifer, Michael
name: Arzt, Michael
Publisher: name: Universität Regensburg
Year: 2014
Subjects: subject: Auto-servo ventilation,Diastolic dysfunction,Heart failure, Sleep apnea, Sleep-disordered breathing
subject: 610 Medizin

description: Background: Systolic heart failure (HF) is frequently accompanied by diastolic dysfunction and sleep-disordered breathing (SDB). Objectives: The objective of this subset analysis was to determine effect sizes of auto-servo ventilation (ASV and biphasic positive airway pressure ASV) on echocardiographic measures of diastolic function in patients with systolic HF and SDB. Methods: Thirty-two patients with stable systolic HF, concomitant diastolic dysfunction [age 66 ± 9 years old, left ventricular (LV) ejection fraction: 30 ± 7% and New York Heart Association class II: 72%] and SDB (apnea-hypopnea index, AHI: 48 ± 19/h; 53% had predominantly obstructive sleep apnea) receiving either ASV (n = 19) or optimal medical treatment (control, n = 13) were analyzed in a randomized controlled clinical trial. Polysomnographic and echocardiographic measurements were obtained at baseline and after 12 weeks. Results: AHI significantly improved in the ASV group compared to the control group (-39 ± 18 vs. -0.2 ± 13.2/h, p < 0.001). At baseline, 24 (75%) patients had impaired LV relaxation, and 8 (25%) had a pseudo-normalized filling pattern. At the 12-week control visit, diastolic function assessed by the isovolumetric relaxation time (-10.3 ± 26.1 vs. 9.3 ± 49.1, p = 0.48) and deceleration time (-43.9 ± 88.8 vs. 12.4 ± 68.8, p = 0.40) tended to improve after ASV treatment, but did not reach statistical significance. Likewise, the proportion of patients whose diastolic dysfunction improved was nonsignificantly higher in the ASV than in the control group, respectively (37 vs. 15%, p = 0.25). Conclusions: ASV treatment efficiently abolishes SDB in patients with stable systolic HF and concomitant diastolic dysfunction, and was associated with a statistically nonsignificant improvement in measures of diastolic dysfunction. Thus, these data provide estimates of effect size and justify the evaluation of the effects of ASV on diastolic function in larger randomized controlled trials.
description: OA-Komponente aus Allianzlizenz
Tobacco Smoke Exposure in Pulmonary Arterial and Thromboembolic Pulmonary Hypertension
Creators: name: Keusch, S.
name: Hildenbrand, F. F.
name: Bollmann, T.
name: Halank, M.
name: Held, Matthias
name: Kaiser, Ralf
name: Kovacs, Gabor
name: Lange, Tobias J.
name: Ulrich, S.
Publisher: name: Universität Regensburg
Year: 2014
Subjects: subject: Chronic thromboembolic pulmonary hypertension, Pulmonary hypertension, Pulmonary arterial hypertension, Tobacco smoke, Smoking, Risk factor
subject: 610 Medizin

description: Background: Animal studies and data from a single-center study suggest that tobacco smoke exposure may be a risk factor for precapillary pulmonary hypertension (PH). Objective: We aimed to survey tobacco smoke exposure in a large PH collective and to compare it with epidemiological data from healthy subjects. Methods: This is an international, multicenter, case-control study including patients with pulmonary arterial and chronic thromboembolic PH. All patients were asked specific questions about tobacco smoke exposure. Healthy controls were retrieved from the Swiss Health Survey (n = 18,747). Results: Overall (n = 472), 49% of PH patients were smokers and there was a clear sex difference (women 37%, men 71%). Significantly more PH men were smokers compared with healthy controls, whereas less PH women were ever active smokers. However, 50% of the non-smoking PH women were exposed to secondhand smoke, leading to a significantly higher number of tobacco smoke-exposed individuals compared to healthy controls. PH smokers were significantly younger compared to those not exposed. Conclusion: Active and environmental tobacco smoke exposure is common in PH. The higher prevalence of male PH smokers, the higher exposure to environmental tobacco smoke in PH women compared to healthy controls and the lower age at PH diagnosis in smokers may indicate a pathogenic role of tobacco smoke exposure in PH.
description: OA-Komponente aus Allianzlizenz
What drives formal and informal cash and in-kind giving, and volunteering, and is the relationship substitutable or complementary? Evidence from Ghana
Creators: name: Osei, Dennis Boahene
name: Alagidede, Imhotep Paul
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Anecdotal evidence of philanthropic practices has accumulated over the years through oral traditions and all over the psyche of the African, yet it is seldom studied empirically. By decomposing charitable giving into its spheres of formal and informal, this study examined the determinants and relationship of charitable giving in Ghana. Our findings, based on survey data from 1,533 household heads and instrumental variable probit model, revealed that while marital status, education, household size, religiosity, ethnicity, and empathic concern are important predictors of formal cash and in-kind giving, informal cash and in-kind giving is driven by income, religiosity and empathic concern. On the other hand, it was evident that formal volunteering is mainly determined by income, household size, religiosity, and empathic concern, whereas gender and religiosity influence informal volunteering. Furthermore, we established that, in both spheres of formal and informal giving, the relationship between cash and in-kind giving and volunteering is complementary. Premised on these findings, we recommend nonprofits and policymakers to recognize the complementary role and distinctive determinants of the spheres of giving in designing tools and policies to raise the levels and effectiveness of fundraising and volunteering campaigns.
On piecewise linear cell decompositions
Creators: name: Kirillov, Alexander
Publisher: name: arXiv
Year: 2010
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics

description: In this note, we introduce a class of cell decompositions of PL manifolds and polyhedra which are more general than triangulations yet not as general as CW complexes; we propose calling them PLCW complexes. The main result is an analog of Alexander's theorem: any two PLCW decompositions of the same polyhedron can be obtained from each other by a sequence of certain "elementary" moves. This definition is motivated by the needs of Topological Quantum Field Theory, especially extended theories as defined by Lurie.
description: LaTeX2e, 11 pages
Transmission of classical and quantum information through a quantum memory channel with damping
Creators: name: D'Arrigo, A.
name: Benenti, G.
name: Falci, G.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We consider the transfer of classical and quantum information through a memory amplitude damping channel. Such a quantum channel is modeled as a damped harmonic oscillator, the interaction between the information carriers - a train of qubits - and the oscillator being of the Jaynes-Cummings kind. We prove that this memory channel is forgetful, so that quantum coding theorems hold for its capacities. We analyze entropic quantities relative to two uses of this channel. We show that memory effects improve the channel aptitude to transmit both classical and quantum information, and we investigate the mechanism by which memory acts in changing the channel transmission properties.
description: 15 pages, 7 figures. The final publication is available at http://www.epj.org
In vitro evaluation of the effects of leukocyte-platelet rich fibrin on disinfection of a rough implant surface
Creators: name: Schuldt, Luisa Antonia
Publisher: name: University of British Columbia
Year: 2017

description: Objectives: Peri-implantitis is a frequent and serious clinical problem affecting between 1 and 47% of implants. Bacterial contamination of the roughened implant surface plays a major role in the etiology and progression of the disease. Successful treatment of peri-implantitis requires disinfection of the rough implant surface. There is no generally accepted protocol for implant disinfection. Autologous leukocyte and platelet-rich fibrin (L-PRF) membranes can be produced from autologous human blood via a one-step centrifugation procedure. It was hypothesized that the antimicrobial defense system of L-PRF may decontaminate the SLAⓇ implant surface. The objective of this study was to test the efficacy of L-PRF for SLAⓇ implant surface disinfection. Methods: Collagen-coated SLAⓇ (sand blasted, large grit acid etched) titanium discs were inoculated with dispersed dental plaque with a minimum bacterial cell concentration of 3.2 × 10⁷ CFU/ml. After 21 days of anaerobic incubation at 37C, discs were rinsed with 12 ml 0.9% NaCl to remove unattached biofilm, and exposed for 48 hours to Leukocyte-Platelet Rich Fibrin (L-PRF) in DMEM. Disks with or without rinsing with 12 ml of 0.9 % NaCl were fixed for SEM. Bacterial counts and perforations in bacteria were quantified from standardized scanning electron micrographs of the implant surface. The rinsing solution was collected and Western blot analysis was performed. L-PRF disks were compared with the control group (rinse). Results: Difference in presence of bacteria displaying perforation of the cell wall between cell–rich L-PRF treated samples and rinsed control group was statistically significant (p < 0.0001, Fisher's Exact Test). Western blot analysis of the rinse fluid demonstrated presence of Platelet Factor-4. Activated platelets in intimate contact with bacteria were detected on SEM images. SEM analysis demonstrated a statistically significant reduction of residual bacteria in the lacunae of the rough SLAⓇ surface after L-PRF treatment. (p< 0.05, Kruskal-Wallis). Conclusions: Autologous L-PRF may have potential as a biological means to decontaminate rough implant surfaces, possibly by exploiting the antimicrobial effects of platelets.
title: ความสัมพันธ์ระหว่างเครือข่ายทางสังคมกับความเหลื่อมล้ำทางดิจิทัลในผู้สูงอายุไทย
Creators: name: สัญญารัตน์ มีสุวรรณ
Publisher: name: สาขารัฐประศาสนศาสตร์ คณะศิลปศาสตร์ มหาวิทยาลัยกาฬสินธุ์
publisherIdentifierScheme: ROR
Year: 2021
Subjects: ความเหลื่อมล้ำทางดิจิทัล
ผู้สูงอายุชาวไทย
เครือข่ายทางสังคม

description: วารสารการบริหารปกครอง, 10, 2, 1-32
Tail approximations of integrals of Gaussian random fields
Creators: name: Liu, Jingchen
Publisher: name: arXiv
Year: 2010
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60F10, 60G70 (Primary)

description: This paper develops asymptotic approximations of $P(\int_Te^{f(t)}\,dt>b)$ as $b\rightarrow\infty$ for a homogeneous smooth Gaussian random field, $f$, living on a compact $d$-dimensional Jordan measurable set $T$. The integral of an exponent of a Gaussian random field is an important random variable for many generic models in spatial point processes, portfolio risk analysis, asset pricing and so forth. The analysis technique consists of two steps: 1. evaluate the tail probability $P(\int_Ξe^{f(t)}\,dt>b)$ over a small domain $Ξ$ depending on $b$, where $\operatorname {mes}(Ξ)\rightarrow0$ as $b\rightarrow \infty$ and $\operatorname {mes}(\cdot)$ is the Lebesgue measure; 2. with $Ξ$ appropriately chosen, we show that $P(\int_Te^{f(t)}\,dt>b)=(1+o(1))\operatorname{mes}(T)\times \operatorname{mes}^{-1}(Ξ)P(\int_Ξe^{f(t)}\,dt>b)$.
description: Published in at http://dx.doi.org/10.1214/10-AOP639 the Annals of Probability (http://www.imstat.org/aop/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Mdm2 SNP309 G-Variant Is Associated with Invasive Growth of Human Urinary Bladder Cancer
Creators: name: Hitzenbichler, F.
name: Stoehr, C. G.
name: Rogenhofer, M.
name: Ruemmele, P.
name: Hartmann, A.
name: Stoehr, Robert
Publisher: name: Universität Regensburg
Year: 2014
Subjects: subject: Mdm2 SNP309, Bladder cancer, p53, Invasion
subject: 610 Medizin

description: Objective: Human mouse double minute 2 (Mdm2) is essential in degrading p53 by acting as an ubiquitin ligase and therefore plays a vital role in cell cycle and survival. The G-variant of the Mdm2 SNP309, which is located within the promoter of the Mdm2 gene, increases expression of Mdm2 and thereby inhibits the p53 pathway. Several studies have investigated the influence of this SNP on disease risk and onset of various malignancies. The impact of Mdm2 SNP309 on bladder cancer is still to be established due to inconsistent data. Methods: In a case-control study we determined the distribution of Mdm2 SNP309 genotypes in 111 patients with an early-onset bladder cancer (diagnosis <45 years of age), in 113 consecutive bladder cancer patients and in a control group consisting of 140 patients without any malignancy. Results: There was no significant association between the allelic distribution of the Mdm2 SNP309 and tumor risk, early onset, gender or grade of the tumor. According to tumor stage we found a significant difference in the distribution of the Mdm2 SNP309 between patients with noninvasive and invasive (≥pT1) tumor growth (p = 0.016). In patients with invasive tumors a significant increase of the G allele was found (T/T vs. T/G + G/G; p = 0.023; OR 2.203, 95% CI 1.111-4.369). Conclusion: These data indicate that the G-variant of the Mdm2 SNP309 might influence the development of a more aggressive tumor phenotype in patients with bladder cancer without affecting the overall tumor risk.
description: OA-Komponente aus Allianzlizenz
title: การประเมินการจัดการเรียนการสอนและการพัฒนาหลักสูตร รัฐประศาสนศาสตรบัณฑิต (หลักสูตรปรับปรุง พ.ศ. 2560) สาขาวิชาวิทยาการจัดการ มหาวิทยาลัยสุโขทัยธรรมาธิราช
Creators: name: จิรวัฒน์ เมธาสุทธิรัตน์
Publisher: name: สาขารัฐประศาสนศาสตร์ คณะศิลปศาสตร์ มหาวิทยาลัยกาฬสินธุ์
publisherIdentifierScheme: ROR
Year: 2021
Subjects: การประเมินและการพัฒนา
หลักสูตรรัฐประศาสนศาสตรบัณฑิต
มหาวิทยาลัยสุโขทัยธรรมาธิราช

description: วารสารการบริหารปกครอง, 10, 2, 33-72
Deterministic LOCC transformation of three-qubit pure states and entanglement transfer
Creators: name: Tajima, Hiroyasu
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: A necessary and sufficient condition of the possibility of a deterministic local operations and classical communication (LOCC) transformation of three-qubit pure states is given. The condition shows that the three-qubit pure states are a partially ordered set parametrized by five well-known entanglement parameters and a novel parameter; the five are the concurrences $C_{AB}$, $C_{AC}$, $C_{BC}$, the tangle $τ_{ABC}$ and the fifth parameter $J_{5}$ of Ref. [18], while the other new one is the entanglement charge $Q_{e}$. The order of the partially ordered set is defined by the possibility of a deterministic LOCC transformation from a state to another state. In this sense, the present condition is an extension of Nielsen's work [20] to three-qubit pure states. We also clarify the rules of transfer and dissipation of the entanglement which is caused by deterministic LOCC transformations. Moreover, the minimum number of times of measurements to reproduce an arbitrary deterministic LOCC transformation between three-qubit pure states is given.
description: 28 pages, 7 figures, To appear in Ann. Phys
Dynamics of Renal Electrolyte Excretion in Growing Mice
Creators: name: Schmidt, Katharina
name: Ripper, Maria
name: Tegtmeier, Ines
name: Humberg, Evelyn
name: Sterner, Christina
name: Reichold, Markus
name: Warth, Richard
name: Bandulik, Sascha
Publisher: name: Universität Regensburg
Year: 2013
Subjects: subject: Genetically modified mice, Growing mice, Postnatal dynamics, Renal electrolyte excretion
subject: 570 Biowissenschaften, Biologie

description: Genetically modified mice represent important models for elucidating renal pathophysiology, but gene deletions frequently cause severe failure to thrive. In such cases, the analysis of the phenotype is often limited to the first weeks of life when renal excretory function undergoes dramatic physiological changes. Here, we investigated the postnatal dynamics of urinary ion excretion in mice. The profiles of urinary electrolyte excretion of mice were examined from birth until after weaning using an automated ion chromatography system. Postnatally, mice grew about 0.4 g/day, except during two phases with slower weight gain: (i) directly after birth during adaptation to extrauterine conditions (P0-P2) and (ii) during the weaning period (P15-P21), when nutrition changed from mother's milk to solid chow and water. During the first 3 days after birth, remarkable changes in urinary Na+, Ca2+, Mg2+, and phosphate concentrations occurred, whereas K+ and Cl- concentrations hardly changed. From days 4-14 after birth, Na+, Ca2+, Mg2+, K+, and Cl- concentrations remained relatively stable at low levels. Urinary concentrations of creatinine, NH4+, phosphate, and sulfate constantly increased from birth until after weaning. Profiles of salt excretion in KCNJ10-/- mice exemplified the relevance of age-dependent analysis of urinary excretion. In conclusion, the most critical phases for analysis of renal ion excretion during the first weeks of life are directly after birth and during the weaning period. The age dependence of urinary excretion varies for the different ions. This should be taken into consideration when the renal phenotype of mice is investigated during the first weeks of life.
description: OA-Komponente aus Allianzlizenz
title: ปัจจัยที่ส่งผลต่อประสิทธิภาพในการทำงานของบุคลากรโรงเรียนที่จัดการศึกษาขั้นพื้นฐานเทศบาลนครนครปฐม
Creators: name: ทัตเทพ ทวีไทย
Publisher: name: สาขารัฐประศาสนศาสตร์ คณะศิลปศาสตร์ มหาวิทยาลัยกาฬสินธุ์
publisherIdentifierScheme: ROR
Year: 2021
Subjects: ประสิทธิภาพในการทำงาน
การจัดการทรัพยากรมนุษย์
แรงจูงใจ
ภาวะผู้นำการเปลี่ยนแปลง
ความผูกพัน

description: วารสารการบริหารปกครอง, 10, 2, 73-87
Inhibition of heat shock protein 90 with AUY922 represses tumor growth in a transgenic mouse model of islet cell neoplasms
Creators: name: Fendrich, Volker
name: Wichmann, Sven
name: Wiese, Dominik
name: Waldmann, Jens
name: Lauth, Matthias
name: Rexin, P.
name: Lopez, C. L.
name: Schlitt, Hans J.
name: Bartsch, D.
name: Lang, Sven A.
Publisher: name: Universität Regensburg
Year: 2014
Subjects: subject: Heat shock protein 90 · AUY922 · Transgenic RIP1-Tag2 mice · Islet cell tumors
subject: 610 Medizin

description: Background: This study was designed to evaluate the role of heat shock protein 90 (HSP90) in tumor progression of murine islet cell tumors. Blockade of HSP90 has recently been proposed as a therapeutic target, but effects in models of islet cell tumors with AUY922, a newly developed HSP90 inhibitor, have not been examined. Material and Methods: The carcinoid cell line BON-1 and the HSP90 inhibitor AUY922 were used to determine effects on signaling and growth in vitro. In vivo transgenic RIP1-Tag2 mice, which develop islet cell neoplasms, were treated with vehicle or AUY922 (25 mg/kg/twice per week) from week 5 until death. The resected pancreata were evaluated macroscopically and microscopically by immunohistochemistry. Quantitative real-time PCR was performed for HSP90 targets with RNA from islets isolated from treated and untreated RIP1-Tag2 mice. Results: HSP90 blockade impaired constitutive and growth factor-induced signaling in vitro. Moreover, HSP90 inhibition attenuated in vitro cell growth in a dose-dependent manner. In vivo, AUY922 significantly reduced tumor volume by 92% compared to untreated controls (p = 0.000), and median survival in the used transgenic mouse model was prolonged (110 vs. 119 days; p = 0.75). Quantitative real-time PCR for downstream target genes of HSP90 demonstrated significant downregulation in the islet cell tumors of RIP1-Tag2 mice treated with AUY922, confirming our ability to achieve effective pharmacologic levels of AUY922 within the desired tissue site in vivo. Conclusion: This is the first study to show that the HSP90 antagonist AUY922 may provide a new option for therapy of islet cell neoplasms.
description: OA-Komponente aus Allianzlizenz
A data analytic-based logistics modelling framework for E-commerce enterprise
Creators: name: Verma, Abhishek
name: Kuo, Yong-Hong
name: Kumar, M Manoj
name: Pratap, Saurabh
name: Chen, Velvet
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Data-driven approaches have noteworthy significance in managing and improving logistics in E-commerce enterprises. This study focuses on the development of an integrated framework to analyse the Brazilian E-Commerce enterprise public dataset. From the analysis, it is found that sellers of Ibitinga city of SP state had the most count of late deliveries where 42 sellers are under-performing in terms of estimated delivery time. Locations of customers and sellers were spotted on a map to get a geographical representation. The proposed framework may help E-Commerce enterprise owners and retail merchants to make better decisions related to sales and E-Commerce enterprise logistics.
The Charlson Comorbidity Index Predicts Survival after Disease Recurrence in Patients following Radical Cystectomy for Urothelial Carcinoma of the Bladder
Creators: name: Mayr, Roman
name: May, M.
name: Burger, Maximilian
name: Martini, T.
name: Pycha, Armin
name: Dechet, C.
name: Lodde, M.
name: Comploj, Evi
name: Wieland, Wolf Ferdinand
name: Denzinger, Stefan
name: Otto, Wolfgang
name: Aziz, Atiqullah
name: Fritsche, Hans-Martin
name: Gierth, Michael
Publisher: name: Universität Regensburg
Year: 2014
Subjects: subject: Bladder cancer, Distant recurrence, Local recurrence, Time to recurrence, Outcome,Transitional cell carcinoma,Comorbidity scores
subject: 610 Medizin

description: Objective: To identify prognostic clinical and histopathological parameters, including comorbidity indices at the time of radical cystectomy (RC), for overall survival (OS) after recurrence following RC for urothelial carcinoma of the bladder (UCB). Materials and Methods: A retrospective multicenter study was carried out in 555 unselected consecutive patients who underwent RC with pelvic lymph node dissection for UCB from 2000 to 2010. A total of 227 patients with recurrence comprised our study group. Cox proportional hazards regression models were calculated with established variables to assess their independent influence on OS after recurrence. Results: The median time from RC to recurrence and the median OS after recurrence was 10.9 and 5.4 months, respectively. Neither the time to recurrence nor the type of recurrence (systematic vs. local) was predictive of the OS. In contrast, age (hazard ratio (HR) 1.53, p = 0.011), lymph node metastasis (HR 1.56, p = 0.007), and positive surgical margins (HR 1.53, p = 0.046) significantly affected the OS after disease recurrence. In addition, the dichotomized Charlson comorbidity index (CCI; dichotomized into >2 vs. 0-2) was the only comorbidity score with an independent prediction of OS (HR 1.41, p = 0.033). We observed a significant gain in the base model's predictive accuracy, i.e. from 68.4 to 70.3% (p < 0.001), after inclusion of the dichotomized CCI. Conclusions: We present the first outcome study of comorbidity indices used as predictors of OS after disease recurrence in patients undergoing RC for UCB. The CCI at the time of RC had no significant influence on the time to recurrence but represented an independent predictor of OS after disease recurrence.
description: OA-Komponente aus Allianzlizenz
Linearized gravity and gauge conditions
Creators: name: Aksteiner, Steffen
name: Andersson, Lars
Publisher: name: arXiv
Year: 2010
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Differential Geometry (math.DG)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: In this paper we consider the field equations for linearized gravity and other integer spin fields on the Kerr spacetime, and more generally on spacetimes of Petrov type D. We give a derivation, using the GHP formalism, of decoupled field equations for the linearized Weyl scalars for all spin weights and identify the gauge source functions occuring in these. For the spin weight 0 Weyl scalar, imposing a generalized harmonic coordinate gauge yields a generalization of the Regge-Wheeler equation. Specializing to the Schwarzschild case, we derive the gauge invariant Regge-Wheeler and Zerilli equation directly from the equation for the spin 0 scalar.
description: 24 pages, corresponds to published version
Diet-Induced and Age-Related Changes in the Quadriceps Muscle: MRI and MRS in a Rat Model of Sarcopenia
Creators: name: Fellner, Claudia
name: Schick, F.
name: Hechtl, Christine
name: Vorbuchner, M.
name: Büttner, Roland
name: Hamer, O. W.
name: Sieber, C. C.
name: Stroszczynski, Christian
name: Bollheimer, L. C.
Publisher: name: Universität Regensburg
Year: 2014
Subjects: subject: Magnetic resonance, Sarcopenia, Aging, Muscle, Fat quantification
subject: 610 Medizin

description: Background: Knowledge about the molecular pathomechanisms of sarcopenia is still sparse, especially with regard to nutritional risk factors and the subtype of sarcopenic obesity. Objective: The aim of this study was to characterize diet-induced and age-related changes on the quality and quantity of the quadriceps muscle in a rat model of sarcopenia by different magnetic resonance (MR) techniques. Methods: A total of 36 6-month-old male Sprague-Dawley rats were randomly subdivided into 2 groups and received either a high-fat diet (HFD) or a control diet (CD). At the age of 16 months, 15 HFD and 18 CD rats underwent MR at 1.5 T. T1-weighted images as well as T2 relaxation time maps were acquired perpendicular to the long axis of the quadriceps muscles. Maximum cross-sectional area (CSA) of the quadriceps muscle was measured on T1-weighted images, and T2 relaxation times of muscle were assessed in a region without visible intramuscular fat (T2lean muscle) and across the complete CSA (T2muscle). Furthermore, 1H-MR spectroscopy was performed to evaluate the relative lipid content of the quadriceps muscles. These measurements were repeated 5 months later in the surviving 8 HFD and 14 CD rats. Results: HFD rats revealed significantly decreased CSA and CSA per body weight (BW) as well as prolonged T2 relaxation times of muscle. A higher weight gain (upper tertile during the first 6 months of diet in CD rats) resulted in a significant change of T2muscle, but had no relevant impact on CSA. Advancing age up to 21 months led to significantly decreased BW, CSA and CSA/BW, significantly prolonged T2muscle and T2lean muscle and enlarged lipid content in the quadriceps muscle. Conclusions: In an experimental setting a chronically fat-enriched diet was shown to have a relevant and age-associated influence on both muscle quantity and quality. By translational means the employed MR techniques give rise to the possibility of an early detection and noninvasive quantification of sarcopenia in humans, which is highly relevant for the field of geriatrics.
description: OA-Komponente aus Allianzlizenz
Trastuzumab Deruxtecan: A Review in Unresectable or Metastatic HER2-Positive Breast Cancer
Creators: name: Nie, Tina
name: Blair, Hannah A.
Publisher: name: Adis Journals
Year: 2023
Subjects: subject: Medicine
subject: 111205 Chemotherapy
subject: FOS: Clinical medicine

description: Declarations Funding The preparation of this review was not supported by any external funding. Authorship and Conflict of interest T. Nie and H. A. Blair are salaried employees of Adis International Ltd/Springer Nature, and declare no relevant conflicts of interest. All authors contributed to the review and are responsible for the article content. Ethics approval, Consent to participate, Consent to publish, Availability of data and material, Code availability Not applicable. Additional information about this Adis Drug Review can be found here. Abstract  Trastuzumab deruxtecan (Enhertu®) is a human epidermal growth factor receptor 2 (HER2)-targeted antibody-drug conjugate approved in several countries, including the USA and those of the EU, for adults with unresectable or metastatic HER2-positive breast cancer who have previously received at least one prior anti-HER2-based regimen. In a pivotal phase 3 trial in this setting, intravenous trastuzumab deruxtecan demonstrated prolonged progression-free survival compared with trastuzumab emtansine (previously the recommended second-line therapy in this indication). Trastuzumab deruxtecan had a generally manageable safety and tolerability profile. Common treatment-related adverse events included haematological and gastrointestinal disorders. Interstitial lung disease (ILD)/pneumonitis is associated with a regulatory warning and requires careful monitoring. In conclusion, trastuzumab deruxtecan is a valuable new treatment option for HER2-positive breast cancer, having been shown to be effective with a generally manageable safety and tolerability profile in adults with unresectable or metastatic disease who have received one or more prior anti-HER2-based regimens. © Springer Nature Switzerland AG 2023
Similar Powers of a Matrix
Creators: name: Bourgeois, Gerald
Publisher: name: arXiv
Year: 2011
Subjects: subject: Rings and Algebras (math.RA)
subject: FOS: Mathematics
subject: 15A24

description: Let $p,q$ be coprime integers such that $|p|+|q|>2$. We characterize the matrices $A\in\mathcal{M}_n(\mathbb{C})$ such that $A^p$ and $A^q$ are similar. If $A$ is invertible, we prove that $A$ is a polynomial in $A^p$ and $A^q$. To achieve this, we study the matrix equation $B^{-1}A^pB=A^q$. We show that for such matrices, $B^{-1}AB$ and $A$ commute. When $A$ is diagonalizable, $A$ is a root of $I_n$ and $B^{-1}AB$ is a power of $A$. We explicitly solve the previous equation when $A$ has $n$ distinct eigenvalues or when $A$ has a sole eigenvalue. In the second part, we completely solve the $2\times{2}$ case of the more general matrix equation $A^{r}B^{s}A^{r'}B^{s'}=\pm{I}_2$.
description: 9 pages. The title is changed. Accepted for publication in "Linear and Multilinear Algebra"
title: "Gruppo di Afrodite con Eros", arte romana, inv. CLXXVII (ITA/EN)
title: Scheda catalogo digitale Borghese
titleType: AlternativeTitle
Creators: name: Clementi, Jessica
name: Galleria Borghese
Publisher: name: Galleria Borghese
Year: 2024

description: Pubblicazione delle schede delle opere conservate nel museo ed estratte dal catalogo digitale di

Galleria Borghese, nelle due versioni esistenti online, in italiano e inglese.

Collegamento al catalogo digitale:

ITA: https://www.collezionegalleriaborghese.it/

EN: https://www.collezionegalleriaborghese.it/en
Künneth Formula in Rabinowitz Floer homology
Creators: name: Kang, Jungsoo
Publisher: name: arXiv
Year: 2010
Subjects: subject: Symplectic Geometry (math.SG)
subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 53D40, 37J10, 58J05

description: Rabinowitz Floer homology has been investigated on a submanifold of contact type. The contact condition, however, is quite restrictive. For example, a product of contact hypersurfaces is rarely of contact type. In this article, we study Rabinowitz Floer homology for a class of non-contact submanifolds. We show for this example that there are infinitely many leafwise intersection points by proving a Künneth formula for Rabinowitz Floer homology.
description: 22 pages, minor corrections, to appear in CVPDE
Sox9 Modulates Proliferation and Expression of Osteogenic Markers of Adipose-Derived Stem Cells (ASC)
Creators: name: Stöckl, Sabine
name: Göttl, Claudia
name: Grifka, Joachim
name: Grässel, Susanne
Publisher: name: Universität Regensburg
Year: 2013
Subjects: subject: Sox9; Osteocalcin; Adipose-derived stem cell; Proliferation; Osteogenesis
subject: 610 Medizin

description: Background: Mesenchymal stem cells (MSC) are promising tools for tissue-engineering and musculoskeletal regeneration. They reside within various tissues, like adipose tissue, periosteum, synovia, muscle, dermis, blood and bone marrow, latter being the most common tissue used for MSC isolation. A promising alternative source for MSC is adipose tissue due to better availability and higher yield of MSC in comparison to bone marrow. A drawback is the yet fragmentary knowledge of adipose-derived stem cell (ASC) physiology in order to make them a safe tool for in vivo application. Methods/Results: Here, we identified Sox9 as a highly expressed and crucial transcription factor in undifferentiated rat ASC (rASC). In comparison to rat bone marrow-derived stem cells (rBMSC), mRNA and protein levels of Sox9 were significantly higher in rASC. To study the role of Sox9 in detail, we silenced Sox9 with shRNA in rASC and examined proliferation, apoptosis and the expression of osteogenic differentiation markers. Our results clearly point to a difference in the expression profile of osteogenic marker genes between undifferentiated rASC and rBMSC in early passages. Sox9 silencing induced the expression of osteocalcin, Vegfα and Mmp13, and decreased rASC proliferation accompanied with an induction of p21 and cyclin D1 expression and delayed S-phase entry. Conclusions: We suggest a pro-proliferative role for Sox9 in undifferentiated rASC which may explain the higher proliferation rate of rASC compared to rBMSC. Moreover, we propose an osteogenic differentiation delaying role of Sox9 in rASC which suggests that Sox9 expression is needed to maintain rASC in an undifferentiated, proliferative state.
description: OA-Komponente aus Allianzlizenz
title: การดำเนินงานของเทศบาลเมืองเขารูปช้าง อำเภอเมือง จังหวัดสงขลา ในการเตรียมความพร้อมเพื่อเข้าสู่สังคมผู้สูงอายุ
Creators: name: กนกวรรณ เรืองศรี
Publisher: name: สาขารัฐประศาสนศาสตร์ คณะศิลปศาสตร์ มหาวิทยาลัยกาฬสินธุ์
publisherIdentifierScheme: ROR
Year: 2021
Subjects: การเตรียมความพร้อม
สังคมผู้สูงอายุ

description: วารสารการบริหารปกครอง, 10, 2, 88-111
Constraining Flavour Symmetries At The EW Scale II: The Fermion Processes
Creators: name: Toorop, Reinier de Adelhart
name: Bazzocchi, Federica
name: Merlo, Luca
name: Paris, Alessio
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the set of models in which the Standard Model symmetry is extended with the flavour group A4 and there are three copies of the Standard Model Higgs that transform as a triplet under this group. In this setup, new channels for flavour violating processes can be studied once the A4 representations of the fermions in the theory are given. We show that it is of great importance to take these constraints into account as they can put severe constraints on the viability of flavour models.
description: 21 pages, 8 figures; version published in JHEP; comments on CP symmetry corrected; results unchanged
title: “เสรีภาพเชิงลบ” คืออะไร ? : บทวิเคราะห์อิสยาห์ เบอร์ลิน
Creators: name: ศักดิ์สิทธิ์ ฆารเลิศ
Publisher: name: สาขารัฐประศาสนศาสตร์ คณะศิลปศาสตร์ มหาวิทยาลัยกาฬสินธุ์
publisherIdentifierScheme: ROR
Year: 2021
Subjects: อิสยาห์ เบอร์ลิน
เสรีภาพเชิงลบ
เสรีภาพเชิงบวก

description: วารสารการบริหารปกครอง, 10, 2, 112-133
Momentum-Dependent Hybridization Gap and dispersive in-gap state of The Kondo Semiconductor SmB6
Creators: name: Miyazaki, Hidetoshi
name: Hajiri, Tetsuya
name: Ito, Takahiro
name: Kunii, Satoru
name: Kimura, Shin-ichi
Publisher: name: arXiv
Year: 2011
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We report the temperature-dependent three-dimensional angle-resolved photoemission spectra of the Kondo semiconductor SmB$_6$. We found a difference in the temperature dependence of the peaks at the X and $Γ$ points, due to hybridization between the Sm 5d conduction band and the nearly localized Sm 4f state. The peak intensity at the X point has the same temperature dependence as the valence transition below 120 K, while that at the $Γ$ point is consistent with the magnetic excitation at Q=(0.5,0.5,0.5) below 30 K. This suggests that the hybridization with the valence transition mainly occurs at the X point, and the initial state of the magnetic excitation is located at the $Γ$ point.
description: 5 pages, 3 figures
Fostering family relationships in long-term care
Creators: name: McDougall, Jennifer
Publisher: name: University of British Columbia
Year: 2017

description: Family relationships are a significant part of a person’s life. Unfortunately, moving a relative from a family home into a long-term care (LTC) home requires the readjustment of family relationships from a familiar to a foreign environment and puts these relationships and associated family identity at risk. With the shift in focus to person-centred care and its need for the maintenance of family connection, the fostering of family relationships in LTC homes becomes an important part of properly enacting this approach to care. This critical ethnography explored the ways in which family relationships are fostered in LTC and identified the efforts made and barriers that exist in the broader organizational and social context of LTC that influence how these relationships are fostered. Data from a larger critical ethnography was collected through semi-structured interviews with and participant observation of 12 family members, seven staff members, and three residents from a LTC home in an urban city in British Columbia, Canada. Family members came into the LTC home to spend time with their relative and maintain a connection with them, but a lack of opportunity to take part in activities that recognized the importance of these connections prevented family relationships from being fostered. Task-focused care overlooked the importance of relational care and further prevented family relationships from being maintained. Physical and cognitive decline also made it difficult for family members to engage and connect with their relative, resulting in a significant impact on the fostering of family relationships. Driving distances and a lack of opportunity to maintain connections with relatives outside of the LTC home added to the challenge of fostering family relationships. Family members want to maintain family identities and associated relationships but require support in doing so. The findings from this study have implications for nursing practice, administration, education, and research.
Itching in Patients with Chronic Hand Eczema: Data from the CARPE Registry
Creators: name: Ruppert, L.
name: Apfelbacher, Christian J.
name: Molin, C.
name: Weisshaar, Elke
Publisher: name: Universität Regensburg
Year: 2014
Subjects: subject: Atopy · Chronic hand eczema · Dermatology Life Quality Index · Eczema · Itch · Pruritus · Quality of life · CARPE registry
subject: 610 Medizin

description: Background: Itching is a leading symptom of chronic hand eczema (CHE) having a great impact on patients. The determinants of itching in CHE are unclear. Objective: We performed a cross-sectional analysis investigating factors associated with the presence and severity of itch in CHE patients from the CARPE registry. Methods: We present baseline data on itch in relationship with sociodemographic factors, severity of CHE, atopy, contact allergy, treatment and patient- reported outcomes including health-related quality of life (HRQoL). Results: Of 1,051 patients with CHE, 78.1% reported itching. Significant positive associations with itching were observed for younger age groups (17-25 and 26-45 years), for moderate, severe and very severe CHE and for small/moderate impairment in HRQoL. Atopic skin diathesis, hardly being able to realize treatment recommendations and very or extremely large impairments in HRQoL were associated with itch severity. Conclusion: Taking the identified variables into account may help identify vulnerable groups most affected by (severe) itch.
description: OA-Komponente aus Allianzlizenz
Bipolarons and polarons in the Holstein-Hubbard model: Analogies and differences
Creators: name: Barišić, O. S.
name: Barišić, S.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: The single bipolaron problem is examined in the context of the 1D Holstein-Hubbard model, emphasizing analogies and differences with respect to the complementary single polaron physics. The bipolaron band structure below the phonon threshold is revealed, showing a complex relationship between numerous excited bands as the adiabatic limit is approached. Light bipolarons with significant binding energy, the stability of large bipolarons, the small to large bipolaron crossover as a function of the Hubbard repulsion, as well as the bipolaron dissociation, are investigated in detail, disentangling adiabatic, nonadiabatic and lattice coarsening effects. It is emphasized that condensation of bipolarons occurs in the dilute limit only at very low temperatures.
description: 12 pages, 7 figures
Disruption of Endogenous Purinergic Signaling Inhibits Vascular Endothelial Growth Factor- and Glutamate-Induced Osmotic Volume Regulation of Muller Glial Cells in Knockout Mice
Creators: name: Grosche, Antje
name: Pannicke, Thomas
name: Chen, Ju
name: Reichenbach, A.
name: Bringmann, A.
Publisher: name: Universität Regensburg
Year: 2013
Subjects: subject: Osmotic swelling; Muller cell; Vascular endothelial growth factor; Glutamate; Calcium
subject: 610 Medizin

description: Background/Aims: Osmotic swelling of Müller cells is a common phenomenon in animal models of ischemic and diabetic retinopathies. Müller cells possess a swelling-inhibitory purinergic signaling cascade which can be activated by various receptor ligands including vascular endothelial growth factor (VEGF) and glutamate. Here, we investigated whether deletion of P2Y1 (P2Y1R) and adenosine A1 receptors (A1AR), and of inositol-1,4,5-trisphosphate-receptor type 2 (IP3R2), in mice affects the inhibitory action of VEGF and glutamate on Müller cell swelling. Methods: The cross-sectional area of Müller cell somata was recorded after a 4-min superfusion of retinal slices with a hypoosmotic solution. Results: Hypoosmolarity induced a swelling of Müller cells from P2Y1R-/-, A1AR-/- and IP3R2-/- mice, but not from wild-type mice. Swelling of wild-type Müller cells was induced by hypoosmotic solution containing barium chloride. Whereas VEGF inhibited the swelling of wild-type Müller cells, it had no swelling-inhibitory effect in cells from A1AR-/- and IP3R2-/- mice. Glutamate inhibited the swelling of wild-type Müller cells but not of cells from P2Y1R-/-, A1AR-/- and IP3R2-/- animals. Conclusion: The swelling-inhibitory effects of VEGF and glutamate in murine Müller cells is mediated by transactivation of P2Y1R and A1AR, as well as by intracellular calcium signaling via activation of IP3R2.
description: OA-Komponente aus Allianzlizenz
Cerium Chloride Reduces Enamel Lesion Initiation and Progression in vitro
Creators: name: Wegehaupt, F. J.
name: Buchalla, Wolfgang
name: Sener, B.
name: Attin, T.
name: Schmidlin, P. R.
Publisher: name: Universität Regensburg
Year: 2014
Subjects: subject: Cerium chloride, Enamel, Fluoride
subject: 610 Medizin

description: Aim: Determination of the potential of cerium chloride to reduce artificial carious mineral loss and lesion depth progression. Methods: A total of 160 enamel samples were prepared from 40 bovine lower central incisors. Crowns were sectioned into four pieces, embedded in acrylic resin, ground flat and allocated to eight groups (S1-S4 and D1-D4; n = 20). Specimens of groups D1-D4 were stored (for 7 days) in a demineralizing buffer solution to induce caries-like lesions. Afterwards, samples were treated for 30 s with one of the following solutions: placebo (S1 and D1), amine fluoride (S2 and D2), cerium chloride (S3 and D3) and a combination of fluoride and cerium chloride (S4 and D4). After another 7 (D1-D4) or 14 (S1-S4) days in demineralizing buffer solution, integrated mineral loss and lesion depth were determined by transversal microradiography and compared by Scheffé's post hoc tests. Results: In groups S1-S4, the highest values for integrated mineral loss and lesion depth were observed for group S1 (placebo), the lowest values for group S4. The results in groups S2-S4 were not significantly different. In groups D1-D4, the highest values for integrated mineral loss and lesion depth were observed for group D1 (placebo), the lowest values in groups D3 and D4. In group D2, integrated mineral loss and lesion depth were significantly lower as compared to D1, but significantly higher compared to groups D3 and D4. Conclusion: Cerium chloride and its combination with fluoride are able to significantly reduce carious mineral loss and the progression of lesion depth.
description: OA-Komponente aus Allianzlizenz