cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Combination of 10% EDTA, Photosan, and a blue light hand-held photopolymerizer to inactivate leading oral bacteria in dentistry in vitro
Creators: name: Maisch, Tim
name: Wagner, J.
name: Papastamou, V.
name: Nerl, H.-J.
name: Hiller, Karl-Anton
name: Szeimies, Rolf-Markus
name: Schmalz, Gottfried
Publisher: name: Universität Regensburg
Year: 2009
Subjects: subject: 610 Medizin

description: AIMS: The goal of this study was to investigate the phototoxicity of Photosan in combination with EDTA and a hand-held photopolymerizer used in dentistry for light-curing resins against leading key pathogens in caries, endodontic treatment failures, and periodontitis respectively. METHODS AND RESULTS: Cellular uptake of Photosan was detected by fluorescence spectroscopy for Streptococcus mutans and Enterococcus faecalis but not for Aggregatibacter actinomycetemcomitans. Addition of 10% EDTA enabled the uptake of Photosan by A. actinomycetemcomitans. Killing of S. mutans and E. faecalis mediated by Photosan and blue light was concentration and light dose dependent, achieving a >or=99.9% (>or=3 log(10) reduction) efficacy of bacteria killing. In the presence of 10% EDTA, Photosan induced a reduction of >or=4 log(10) in the viability of A. actinomycetemcomitans at a concentration of 50 microg ml(-1), upon activation at a dose of 9.65 J cm(-2) for 60 s. EDTA alone, light alone, and Photosan alone were not able to kill bacteria. CONCLUSIONS: Ten per cent EDTA and Photosan cause a potent phototoxicity against oral bacteria upon illumination with a photopolymerizer. SIGNIFICANCE AND IMPACT OF THE STUDY: Increasing antibiotic resistance and insufficient drug concentrations within the sulcus fluid are responsible for lacking antimicrobial efficacy. This study provides useful information that combination of Photosan, EDTA, and a photopolymerizer may be a potentially powerful tool for the efficient destroying of key oral bacteria.
Additional file 1 of Mitochondrial defects in the respiratory complex I contribute to impaired translational initiation via ROS and energy homeostasis in SMA motor neurons
Creators: name: Thelen, Maximilian Paul
name: Wirth, Brunhilde
name: Kye, Min Jeong
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Marine Biology
subject: Computational Biology

description: Additional file 1: Supplementary Table S1. Primer sequences. S2. Antibodies and conditions for Western blot (WB) and immunofluorescence (IF). S3. Fluorescence dyes. S4. Drugs and supplements for in vitro assays.
Sludge reduction by mixed liquor ozonation
Creators: name: Zheng, Xiaoyu
Publisher: name: University of British Columbia
Year: 2018

description: In this comparative study, a combination of mixed liquor ozone treatment and an enhanced biological phosphorus removal (EBPR) process with long SRT operations (25 d and 50 d) was tested for sludge reduction. An equivalent to about 80% sludge reduction was achieved in an EBPR system with mixed liquor ozonation and with long SRT operation. The effluent quality was not affected with mixed liquor ozonation at SRT = 50 d. Both the control and the ozone-treated systems achieved about 90 ± 1% COD, 99 ± 1 % ammonia, 79 ± 1% inorganic nitrogen, and about 94 ± 1% ortho-phosphorus removal efficiencies at SRT = 50 d. The mixed liquor in both systems hosted a similiar fraction of active organisms. The mixed liquor in the ozonated system exhibited a different composition of the bacteria community compared with that in the control by the Analysis of 16S rDNA. The low diversity of microbial community was observed in the ozonated reactor. The nitrification was not affected in the ozonated system. The specific ammonium removal efficiency was comparable to that in the control. Similar fraction and diversity of nitrifiers were identified in the ozonated system and in the control. The phosphorus removal performance was not adversely affected in the ozonated system at SRT = 50 d. The maximum P-release rate and the maximum P-uptake rate in the ozonated reactor were similar to the control. The heterotrophic decay coefficients in both reactors had no statistically siginficant difference. The maximum specific growth rate in the ozonated system (6.21 ± 0.31 d-¹) was less than that in the control reactor (8.31 ± 0.55 d-¹). The mixed liquor ozonation batch tests indicated that there was an optimum TSS/VSS concentration at which the maximum soluble COD was achieved. Carbonate/bicarbonate addition may reduce the efficiency of sludge disintegration. The solids solubilization was significantly improved under high pH conditions. The zero sludge EBPR SBR process at lab-scale was proposed and tested. The optimum ozone dosage was determined and no inorganic matter accumulation was observed. By the batch P-release and discharge operations, the system maintained P mass balance and no P accumulation were observed.
Test for Lorentz and CPT Violation with the MiniBooNE Low-Energy Excess
Creators: name: Katori, Teppei
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The MiniBooNE experiment is a $ν_μ\toν_e$ and $\barν_μ\to\barν_e$ appearance neutrino oscillation experiment at Fermilab. The neutrino mode oscillation analysis shows an excess of $ν_e$ candidate events in the low-energy region. These events are analyzed under the SME formalism, utilizing the short baseline approximation. The preliminary result shows the time independent solution is favored. The relationship with the SME parameters extracted from the LSND experiment is discussed. The systematic error analysis and antineutrino mode analysis are outlined.
description: Presented at the Fifth Meeting on CPT and Lorentz Symmetry, Bloomington, Indiana, June 28-July 2, 2010
Prozessentwicklung einer kontinuierlichen in situ-Produktkristallisation für Transaminase-katalysierte Reaktionen
Creators: name: Hülsewede, Dennis
Publisher: name: Universität Rostock
Year: 2021
Subjects: subject: 660 Chemical engineering

description: Die vorgelegte Arbeit beschreibt eine nicht-katalytische Methode zur Verschiebung des Reaktionsgleichgewichts und der Produktivität von Transaminase-katalysierten Reaktionen. Durch die Zugabe einer Carbonsäure wird selektiv das Produktamin als schwerlösliches Ammoniumsalz auskristallisiert. Zur weiteren Steigerung der Produktivität wurde ein semi-kontinuierliches Reaktorsystem entwickelt, welches den Ganzzellbiokatalysator in einem Membranreaktor immobilisiert. Somit können chirale Amine auf biokatalytischem Weg kontinuierlich hergestellt werden.
Mittelfristige Ergebnisstudie nach Aortenklappenersatz mit der St. Jude Medical Trifecta Bioprothese im Hinblick auf Morbidität, Mortalität und Hämodynamik
Creators: name: Merkl, Ruth
Publisher: name: Universität Rostock
Year: 2020
Subjects: subject: 610 Medical sciences Medicine

description: Die Arbeit stellt die kurz- und mittelfristigen Ergebnisse von 100 Patienten, die im Jahr 2011 einen Aortenklappenersatz mit der St Jude Medical Trifecta Bioprothese an der Herzchirurgischen Abteilung des Universitätsklinikum Rostock erhielten, hinsichtlich Hämodynamik, Morbidität und Mortalität vor, und vergleicht diese mit den Ergebnissen aus anderen Zentren. In unserer Arbeit zeigt die Trifecta Prothese gute hämodynamische und klinische Ergebnisse, die mit den Ergebnissen anderer Trifecta Studien und der zum Vergleich herangezogenen Prothesen CEP Magna und Sorin Mitroflow vergleichbar sind.
null Konnektom des Hirnstamms der Laborratte
Creators: name: Beier, Julia Iris
Publisher: name: Universität Rostock
Year: 2020
Subjects: subject: 610 Medical sciences Medicine

description: Die Konnektomanalyse des Hirnstammes geht von 310 unilateralen Regionen im Hirnstamm aus. Sie wurden als Hierarchie und als 3D-Visualisierung uni- und bilateral dargestellt. In drei Datenbanken wurden 587 Publikationen identifiziert, die vor allem aus intrinsischen Verbindungen bestehen und u.a. von mir erfasst wurden.
System-level design of energy-efficient sensor-based human activity recognition systems
Creators: name: Grützmacher, Florian
Publisher: name: Universität Rostock
Year: 2021
Subjects: subject: 000 Generalities, Science
subject: 621.3 Electrical Engineering, Electronics

description: This thesis contributes an evaluation of state-of-the-art dataflow models of computation regarding their suitability for a model-based design and analysis of human activity recognition systems, in terms of expressiveness and analyzability, as well as model accuracy. Different aspects of state-of-the-art human activity recognition systems have been modeled and analyzed. Based on existing methods, novel analysis approaches have been developed to acquire extra-functional properties like processor utilization, data communication rates, and finally energy consumption of the system.
PhD Thesis: Causation and Modality
Creators: name: McHugh, D.M.
Publisher: name: University of Amsterdam / Amsterdam University of Applied Sciences
Year: 2023
Subjects: subject: Humanities
subject: FOS: Humanities
subject: 20 Language, Communication and Culture
subject: Information and Computing Sciences
subject: Mathematics
subject: FOS: Mathematics

description: Abstract. This thesis aims to answer two questions about causal claims (such as sentences containing ‘cause’ or ‘because’). Firstly, the modelling question: what kind of information do we use when we judge that a causal claim holds? Secondly, the meaning question: under what conditions do we judge that a causal claim is true?

 Our answer to the modelling question is that a causal model must contain time, part–whole structure, and nomic possibility. The model represents scenarios as extended in time, with each moment in time having a mereological structure (the mereological structure tell us, for example, that the state of Amsterdam is part the state of the Netherlands). The notion of nomic possibility specifies which worlds are nomically possible and which worlds are nomically impossible; in other words, which worlds satisfy the laws and which do not. In addition, the model must also contain two language-related components. For each sentence, the model must tell us what parts of the world it is about, and in which worlds the sentence is true.

 We show that this this modelling framework is strictly more general than a popular alternative, that of structural causal models. Every structural causal model can be represented into our framework, and therefore every scenario that structural causal models can represent our framework can represent too. However, the converse does not hold. There are some scenarios that our proposed model can represent which structural causal models cannot.

 We use these components to analyse how people construct hypothetical alternatives to reality. For it is commonly thought that the truth of a causal claim depends not only on what goes on in the actual world, but on what happens in some hypothetical scenarios as well. For example, when we evaluate “Alice missed her flight because she got stuck in traffic” we imagine scenarios where she is stuck in traffic and scenarios where she is not, and compare what happens in each.

 We then analyse the semantics of ‘cause’ and ‘because’ in terms of two relations: sufficiency and production. The meaning of ‘cause’ and ‘because’ is a blend of these relations: ‘C cause E’ and ‘E because C’ are true just in case C is true, and C is sufficient to produce E but C's negation is not.
Evidence of gate-tunable topological excitations in two-dimensional electron systems
Creators: name: Koushik, R.
name: Baenninger, Matthias
name: Narayan, Vijay
name: Mukerjee, Subroto
name: Pepper, Michael
name: Farrer, Ian
name: Ritchie, David A.
name: Ghosh, Arindam
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Topological defects are ubiquitous from solid state physics to cosmology, where they drive phase transitions by proliferating as domain walls, monopoles or vortices. As quantum excitations, they often display fractional charge and anyonic statistics, making them relevant to topologically protected quantum computation, but realizing a controlled physical resource for topological excitations has been difficult. Here we report evidence of topological excitations during the localization transition in strongly interacting two-dimensional electron systems (2DESs) in GaAs/AlGaAs heterostructures. We find the electrical conductivity at low electron densities to follow a Berezinskii-Kosterlitz Thouless (BKT)-like order-disorder transition implying a gate-tunable proliferation of charged topological defects. At low temperatures, a weakening in the temperature dependence of conductivity was observed, and linked to the zero point fluctuations and delocalization of the defects. Our experiments also cast crucial insight on the nature of the ground state in strongly interacting 2DESs in presence of disorder.
description: 4 figures
Histidine residues at the copper-binding site in human tyrosinase are essential for its catalytic activities
Creators: name: Noh, Hyangsoon
name: Lee, Sung Jun
name: Jo, Hyun-Joo
name: Choi, Hye Won
name: Hong, Sungguan
name: Kong, Kwang-Hoon
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Tyrosinase is a copper-binding enzyme involved in melanin biosynthesis. However, the detailed structure of human tyrosinase has not yet been solved, along with the identification of the key sites responsible for its catalytic activity. We used site-directed mutagenesis to identify the residues critical for the copper binding of human tyrosinase. Seven histidine mutants in the two copper-binding sites were generated, and catalytic activities were characterised. The tyrosine hydroxylase activities of the CuA site mutants were approximately 50% lower than those of the wild-type tyrosinase, while the dopa oxidation activities of the mutants were not significantly different from that of wild-type tyrosinase. By contrast, mutations at CuB significantly decreased both tyrosine hydroxylation and dopa oxidation activities, confirming that the catalytic sites for these two activities are at least partially distinct. These findings provide a useful resource for further structural determination and development of tyrosinase inhibitors in the cosmetic and pharmaceutical industries.
Zur Komplexität der Synthese von Petri-Netzen
Creators: name: Tredup, Ronny
Publisher: name: Universität Rostock
Year: 2021
Subjects: subject: 004 Data processing Computer sciences

description: Petri-Netz-Synthese fragt für ein reguläres Verhalten, das als Transitionssystem A gegeben ist, ob es ein Petri-Netz (einer bestimmten Klasse) gibt, das A implementiert. Diese Arbeit untersucht Varianten dieses Entscheidungsproblems für verschiedene Implementierungen und eine Vielzahl von Petri-Netz-Klassen aus Sicht der klassischen und der parametrisierten Komplexität. Ebenso wird die Komplexität der Modifikations-Techniken Neubeschriftung sowie Kanten-, Ereignis- und Zustandslöschung untersucht, die darauf abzielen, nicht-implememtierbare Transitionssysteme implementierbar zu machen.
The Carbonic Anhydrase IX inhibitor SLC-0111 as emerging agent against the mesenchymal stem cell-derived pro-survival effects on melanoma cells
Creators: name: Peppicelli, Silvia
name: Andreucci, Elena
name: Ruzzolini, Jessica
name: Bianchini, Francesca
name: Nediani, Chiara
name: Supuran, Claudiu T.
name: Calorini, Lido
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Mesenchymal stem cells (MSC) take part to solid tumour-associated stroma and critically influence progression of malignancy. Our study represents a striking example of melanoma progression to a more malignant and resistant phenotype promoted by MSC and the possibility to contrast this diabolic liaison using CAIX inhibitors. In particular, we demonstrated that melanoma cells exposed to a MSC-conditioned medium switch to a more malignant phenotype, characterised by resistance to programmed cell death and endowed with an epithelial-to-mesenchymal transition and stem cell characteristics. These effects were reversed abrogating MSC CAIX activity using SLC-0111, a CAIX inhibitor. Moreover, the acquisition by melanoma cells of a Vemurafenib-resistant phenotype upon MSC-conditioned medium exposure was removed when MSC were treated with SLC-0111. Therefore, MSC may profoundly reprogramme melanoma cells towards a wide resistant phenotype through CAIX involvement, as the use of SLC-0111 is able to contrast the development of this highly risky adaptation for disease progression.
Deep Spitzer observations of infrared-faint radio sources: high-redshift radio-loud AGN?
Creators: name: Norris, Ray P.
name: Afonso, Jose
name: Cava, Antonio
name: Farrah, Duncan
name: Huynh, Minh T.
name: Ivison, R. J.
name: Jarvis, Matt
name: Lacy, Mark
name: Mao, Minnie
name: Maraston, Claudia
name: Mauduit, Jean-Christophe
name: Middelberg, Enno
name: Oliver, Seb
name: Seymour, Nick
name: Surace, Jason
Publisher: name: arXiv
Year: 2011
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Infrared-faint radio sources (IFRSs) are a rare class of object which are relatively bright at radio wavelengths but very faint at infrared and optical wavelengths. Here we present sensitive near-infrared observations of a sample of these sources taken as part of the Spitzer Extragalactic Representative Volume Survey (SERVS). Nearly all the IFRSs are undetected at a level of ~ 1 μ$Jy in these new deep observations, and even the detections are consistent with confusion with unrelated galaxies. A stacked image implies that the median flux density is $S_{3.6μm} ~ 0.2$ μ$Jy or less, giving extreme values of the radio-infrared flux density ratio. Comparison of these objects with known classes of object suggests that the majority are probably high-redshift radio-loud galaxies, possibly suffering from significant dust extinction.
Additional file 3 of Mitochondrial defects in the respiratory complex I contribute to impaired translational initiation via ROS and energy homeostasis in SMA motor neurons
Creators: name: Thelen, Maximilian Paul
name: Wirth, Brunhilde
name: Kye, Min Jeong
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Marine Biology
subject: Computational Biology

description: Additional file 3: Supplementary Figure S1. Complex I deficiency leads to dysfunctional and fragmented mitochondria. S2. Mitochondrial complex I is impaired in SMA MNs. S3. Optimization of SUnSET assay. S4. Reduction of ROS improves protein synthesis in SMA MNs, but not in WT MNs. S5 Whole cell proteome after modifying ROS levels. S6 Proteins related to translation are significantly changed in SMA MNs without affecting elongation speed. S7. Pyruvate regulates SMN levels.
Источники формирования русской эрратографии
Creators: name: Метлякова, Елена
Publisher: name: ООО Цифра
Year: 2023
Subjects: Russian writing
errative
erratography
errative writing
русское письмо
эрратив
эрратография
эрративное письмо

description: Russian Linguistic Bulletin, Выпуск 12 (48) 2023
Experimentelle Untersuchung der thermischen Aktivierung und des Entschwefelungsverhaltens von Natriumhydrogencarbonat im Abgastrakt schwerölbetriebener Großdieselmotorenkraftwerke
Creators: name: Schäfer, Stefan
Publisher: name: Universität Rostock
Year: 2021
Subjects: subject: 620 Engineering & allied operations

description: Das Verhalten von Natriumhydrogencarbonat im Abgastrakt wird in einem weiten Temperaturbereich und unter Variation der Additivkorngröße experimentell untersucht. Ein Prüfstand wird entwickelt und umgesetzt, welcher die Bedingungen im Abgastrakt eines realen Kraftwerk nachbildet. Es wird untersucht, ob der in statischen Versuchen beobachtete Effekt der Oberflächenversinterung, welcher ursächlich für die mangelnde Eignung bei Temperaturen über 300 °C sein soll, auch unter dynamischen Bedingungen auftritt oder durch bisher unbekannte Phänomene abgeschwächt oder sogar ausgeglichen wird.
Flow pattern transition accompanied with sudden growth of flow resistance in two-dimensional curvilinear viscoelastic flows
Creators: name: Yatou, Hiroki
Publisher: name: arXiv
Year: 2010
Subjects: subject: Pattern Formation and Solitons (nlin.PS)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We find three types of steady solutions and remarkable flow pattern transitions between them in a two-dimensional wavy-walled channel for low to moderate Reynolds (Re) and Weissenberg (Wi) numbers using direct numerical simulations with spectral element method. The solutions are called "convective", "transition", and "elastic" in ascending order of Wi. In the convective region in the Re-Wi parameter space, the convective effect and the pressure gradient balance on average. As Wi increases, the elastic effect becomes suddenly comparable and the first transition sets in. Through the transition, a separation vortex disappears and a jet flow induced close to the wall by the viscoelasticity moves into the bulk; The viscous drag significantly drops and the elastic wall friction rises sharply. This transition is caused by an elastic force in the streamwise direction due to the competition of the convective and elastic effects. In the transition region, the convective and elastic effects balance. When the elastic effect dominates the convective effect, the second transition occurs but it is relatively moderate. The second one seems to be governed by so-called Weissenberg effect. These transitions are not sensitive to driving forces. By the scaling analysis, it is shown that the stress component is proportional to the Reynolds number on the boundary of the first transition in the Re-Wi space. This scaling coincides well with the numerical result.
description: 33pages, 23figures, submitted to Physical Review E
THE ALGEBRAIC FORMULATION OF THE OPEN-SOURCE ENERGY MODELING SYSTEM (OSeMOSYS)
Creators: name: Benbrahim, Souhila
name: Saloua, Chaouche
name: Toumache, Rachid
Publisher: name: figshare
Year: 2023
Subjects: Ecological economics

description: This paper discusses the mathematical analogy of the Open-Source Energy Modeling System (OSeMOSYS).
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers
Creators: name: Braconi, Laura
name: Bartolucci, Gianluca
name: Contino, Marialessandra
name: Chiaramonte, Niccolò
name: Giampietro, Roberta
name: Manetti, Dina
name: Perrone, Maria Grazia
name: Romanelli, Maria Novella
name: Colabufo, Nicola Antonio
name: Riganti, Chiara
name: Dei, Silvia
name: Teodori, Elisabetta
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Plant Biology

description: Aiming to deepen the structure–activity relationships of the two P-glycoprotein (P-gp) modulators elacridar and tariquidar, a new series of amide and ester derivatives carrying a 6,7-dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline scaffold linked to different methoxy-substituted aryl moieties were synthesised. The obtained compounds were evaluated for their P-gp interaction profile and selectivity towards the two other ABC transporters, multidrug-resistance-associated protein-1 and breast cancer resistance protein, showing to be very active and selective versus P-gp. Two amide derivatives, displaying the best P-gp activity, were tested in co-administration with the antineoplastic drug doxorubicin in different cancer cell lines, showing a significant sensitising activity towards doxorubicin. The investigation on the chemical stability of the derivatives towards spontaneous or enzymatic hydrolysis, showed that amides are stable in both models while some ester compounds were hydrolysed in human plasma. This study allowed us to identify two chemosensitizers that behave as non-transported substrates and are characterised by different selectivity profiles.
Additional file 1 of Germline variation of Ribonuclease H2 genes in ovarian cancer patients
Creators: name: Polaczek, Rahel
name: Schürmann, Peter
name: Lisa-Marie Speith
name: Geffers, Robert
name: Dürst, Matthias
name: Hillemanns, Peter
name: Tjoung-Won Park-Simon
name: Liebrich, Clemens
name: Dörk, Thilo
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Supplementary Figure 1: Identified missense and truncating variants of RHASEH2B.
Design, synthesis and in vitro antiproliferative activity of new thiazolidinedione-1,3,4-oxadiazole hybrids as thymidylate synthase inhibitors
Creators: name: Alzhrani, Zohor Mohammad Mahdi
name: Alam, Mohammad Mahboob
name: Neamatallah, Thikryat
name: Nazreen, Syed
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: Thymidylate synthase (TS) has been an attention-grabbing area of research for the treatment of cancers due to their role in DNA biosynthesis. In the present study, we have synthesised a library of thiazolidinedione-1,3,4-oxadiazole hybrids as TS inhibitors. All the synthesised hybrids followed Lipinski and Veber rules which indicated good drug likeness properties upon oral administration. Among the synthesised hybrids, compound 9 and 10 displayed 4.5 and 4.4 folds activity of 5-Fluorouracil, respectively against MCF-7 cell line whereas 3.1 and 2.5 folds cytotoxicity against HCT-116 cell line. Furthermore, compound 9 and 10 also inhibited TS enzyme with IC50 = 1.67 and 2.21 µM, respectively. Finally, the docking studies of 9 and 10 were found to be consistent with in vitro TS results. From these studies, compound 9 and 10 has the potential to be developed as TS inhibitors.
An approximation of the distribution of learning estimates in macroeconomic models
Creators: name: Kingeski Galimberti, Jaqueson
Publisher: name: ETH Zurich
Year: 2019
Subjects: Constant-gain
Policy stability
Adaptive learning
Expectations

description: Adaptive learning under constant-gain allows persistent deviations of beliefs from equilibrium so as to more realistically reflect agents’ attempt of tracking the continuous evolution of the economy. A characterization of these beliefs is therefore paramount to a proper understanding of the role of expectations in the determination of macroeconomic outcomes. In this paper we propose a simple approximation of the first two moments (mean and variance) of the asymptotic distribution of learning estimates for a general class of dynamic macroeconomic models under constant-gain learning. Our approximation provides renewed convergence conditions that depend on the learning gain and the model’s structural parameters. We validate the accuracy of our approximation with numerical simulations of a Cobweb model, a standard New-Keynesian model, and a model including a lagged endogenous variable. The relevance of our results is further evidenced by an analysis of learning stability and the effects of alternative specifications of interest rate policy rules on the distribution of agents’ beliefs.
description: KOF Working Papers, 453
A case study of the BalancedView course : addressing weight stigma among health care providers in British Columbia
Creators: name: O'Reilly, Caitlin Joyce
Publisher: name: University of British Columbia
Year: 2018

description: Growing evidence shows weight stigma as a problem in health care settings. However, there remains a lack of conceptual clarity – particularly regarding if and how the medicalization of weight is implicated in weight stigma – and a gap in knowledge about how to successfully reduce weight stigma in health care. The research questions that guided this study were thus: • What are the different ways that weight stigma in health care can be conceptualized? • What strategies can be employed to reduce weight stigma among health care providers? These questions were explored through a mixed methods case study of the development and implementation of an online course on weight stigma for health care providers in British Columbia called BalancedView, sponsored by the Provincial Health Services Authority. Using participant observation, document analysis, a focus group and semi-structured interviews, I examined how health care stakeholders who developed the course, and participants who went on to take the course, conceptualized weight stigma. I evaluated the effects of the course on 249 participating health care providers through questionnaires before and after the course. Using interviews with course participants and documentary analysis of qualitative comments made by participants during the course, I also explored what was most helpful about the course and why. Following a thematic analysis, I show how weight stigma was conceptualized as a process involving biased attitudes and beliefs that lead to discriminatory behaviours and adverse outcomes. It was perceived as a causally complex issue, with a relationship to emotions. The extent to which the medicalization of weight was viewed as part of weight stigma was a divisive topic in the development stage of the course. However, many participants who took the course reflected later that after learning about medicalization they saw harms in medicalized approaches to weight in health care. This study contributes to the currently limited literature on weight stigma reduction in health care. I demonstrate how an online course on weight stigma that uses multiple stigma reduction techniques had a positive effect in terms of reducing participants’ weight bias and discuss what essential elements within such interventions should be.
Additional file 2 of Germline variation of Ribonuclease H2 genes in ovarian cancer patients
Creators: name: Polaczek, Rahel
name: Schürmann, Peter
name: Lisa-Marie Speith
name: Geffers, Robert
name: Dürst, Matthias
name: Hillemanns, Peter
name: Tjoung-Won Park-Simon
name: Liebrich, Clemens
name: Dörk, Thilo
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2: Supplementary Table S1: Primer sequences for RNASEH2A, RNASEH2B and RNASEH2C amplification.
Höflicher Rat, ratende Höflichkeit
Creators: name: Reichetanz, Paul
Publisher: name: Universität Rostock
Year: 2020
Subjects: subject: 400 Language, Linguistics
subject: 470 Italic Latin
subject: 870 Italic literatures Latin

description: Die Arbeit zeigt, dass briefliche Beratung im Rom der Späten Republik und Frühen Kaiserzeit spezifischen Normen unterliegt. Durch einen linguistischen Ansatz werden die Formulierungsmöglichkeiten des Sprechers systematischer als bisher erfasst. Die Analyse dieser Äußerungen und der Höflichkeitsstrategien anhand von vier Briefen (Cic. Q. fr. 1,1; Epistulae ad Caesarem; Plin. Epist. 8,24) offenbart schließlich das Vorhandensein der Untergattung „Beratungsbrief“ und ermöglicht dessen Abgrenzung von ähnlichen Textsorten (Handbuch, philosophischer Lehrbrief).
Pattern tree-based XOLAP rollup operator for XML complex hierarchies
Creators: name: Hachicha, Marouane
name: Darmont, Jérôme
Publisher: name: arXiv
Year: 2011
Subjects: subject: Databases (cs.DB)
subject: FOS: Computer and information sciences

description: With the rise of XML as a standard for representing business data, XML data warehousing appears as a suitable solution for decision-support applications. In this context, it is necessary to allow OLAP analyses on XML data cubes. Thus, XQuery extensions are needed. To define a formal framework and allow much-needed performance optimizations on analytical queries expressed in XQuery, defining an algebra is desirable. However, XML-OLAP (XOLAP) algebras from the literature still largely rely on the relational model. Hence, we propose in this paper a rollup operator based on a pattern tree in order to handle multidimensional XML data expressed within complex hierarchies.
HIV-2-Testung in der HIV-Tagesklinik des Regional Hospital Limbe und Deutung im Hinblick auf Fälle von Versagen der HIV-Erstlinientherapie
Creators: name: Kruckow, Charlotte Katharina Jeanette
Publisher: name: Universität Rostock
Year: 2020
Subjects: subject: 610 Medical sciences Medicine

description: In der HIV-Tagesklinik des Regional Hospital Limbe wurden HIV-positive Patientenseren mittels serologischer und molekularbiologischer Tests auf das Vorliegen einer HIV-2-Infektion untersucht. Sowohl therapienaive Patienten als auch Patienten, die ein Therapieversagen aufwiesen, wurden getestet. In den untersuchten Patientengruppen fand sich keine HIV-2-Monoinfektion, jedoch sechs Patienten mit einer HIV-1/2-Doppelinfektion. Diese stammten aus der Gruppe der Therapienaiven. HIV-2 Infektionen treten im Kontext des RHL auf und müssen in Diagnostik und Therapie berücksichtigt werden.
Comments on matter collineations of plane symmetric, cylindrically symmetric and spherically symmetric spacetimes
Creators: name: Qadir, Asghar
name: Saifullah, K.
Publisher: name: arXiv
Year: 2010
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: Comments are made on some recently published papers on matter collineations of plane symmetric, cylindrically symmetric and spherically symmetric spacetimes.
ТЕРМИНЫ ПРИКЛАДНОЙ ЭКОЛОГИИ СОВРЕМЕННОГО АНГЛИЙСКОГО ЯЗЫКА: СТРУКТУРА И ДИНАМИКА
Creators: name: Сообщество рецензентов Международного научно-исследовательского журнала
Publisher: name: ООО Цифра
Year: 2023
Subjects: term
terminology
applied ecology
morphological-syntactic structure
derivational model
термин
терминология
прикладная экология
морфолого-синтаксическая структура
деривационная модель

description: Russian Linguistic Bulletin, Выпуск 12 (48) 2023
Synthesis and biological activity of 2-cyanoacrylamide derivatives tethered to imidazopyridine as TAK1 inhibitors
Creators: name: Kang, Seok Jong
name: Lee, Jung Wuk
name: Song, Jiho
name: Park, Jiwon
name: Choi, Jaeyul
name: Suh, Kwee Hyun
name: Min, Kyung Hoon
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: The importance of transforming growth factor beta-activated kinase 1 (TAK1) to cell survival has been demonstrated in many studies. TAK1 regulates signalling cascades, the NF-κB pathway and the mitogen-activated protein kinase (MAPK) pathway. TAK1 inhibitors can induce the apoptosis of cancerous cells, and irreversible inhibitors such as (5Z)-7-oxozeaenol are highly potent. However, they can react non-specifically with cysteine residues in proteins, which may have serious adverse effects. Reversible covalent inhibitors have been suggested as alternatives. We synthesised imidazopyridine derivatives as novel TAK1 inhibitors, which have 2-cyanoacrylamide moiety that can form reversible covalent bonding. A derivative with 2-cyano-3-(6-methylpyridin-2-yl)acrylamide (13h) exhibited potent TAK1 inhibitory activity with an IC50 of 27 nM. It showed a reversible reaction with β-mercaptoethanol, which supports its potential as a reversible covalent inhibitor.
A transmission electron microscopy study of presolar hibonite
Creators: name: Zega, Thomas J.
name: Alexander, Conel M. O'D.
name: Nittler, Larry R.
name: Stroud, Rhonda M.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We report isotopic and microstructural data on five presolar hibonite grains identified in an acid residue of the Krymka LL3.1 ordinary chondrite. Isotopic measurements by secondary ion mass spectrometry (SIMS) verified a presolar circumstellar origin for the grains. Transmission electron microscopy (TEM) examination of the crystal structure and chemistry of the grains was enabled by in situ sectioning and lift-out with a focused-ion-beam scanning-electron microscope. Comparisons of isotopic compositions with models indicate that four of the five grains formed in low-mass stars that evolved through the red-giant/asymptotic-giant branches, whereas one grain formed in the ejecta of a Type II supernova. Selected-area electron-diffraction patterns show that all grains are single crystals of hibonite. Some grains contain stacking faults and small spreads in orientation that can be attributed to a combination of growth defects and mechanical processing by grain-grain collisions. The similar structure of the supernova grain to those from RGB/AGB stars indicates a similarity in the formation conditions. Radiation damage, if present, occurs below our detection limit. Of the five grains we studied, only one has the pure hibonite composition of CaAl12O19. All others contain minor amounts of Mg, Si, Ti, and Fe. The microstructural data are generally consistent with theoretical predictions, which constrain the circumstellar condensation temperature to a range of 1480 K to 1743 K, assuming a corresponding total gas pressure between 1 x 10-3 and 1 x 10-6 atm. The TEM data were used to develop a calibration for SIMS determination of Ti contents in oxide grains. Grains with extreme 18O depletions, indicating deep mixing has occurred in their parent AGB stars, are slightly Ti-enriched compared to grains from stars without deep mixing, most likely reflecting differences in grain condensation conditions.
Evaluation of solder joints on aluminum surfaces for the interconnection of silicon solar cells
Creators: name: De Rose, Angela
Publisher: name: Universität Rostock
Year: 2021
Subjects: subject: 620 Engineering & allied operations
subject: 621.3 Electrical Engineering, Electronics

description: In this thesis, direct soldering of aluminum is investigated, with a special focus on appplication in the photovoltaic industry. The native Al2O3 layer impedes the solderability of Al components. However, strong solder joints can be formed when suitable surface coatings are used. The formation of solder joints and the relevant fundamental properties of these joints and coatings are evaluated.
Conformal Ricci collineations of static spherically symmetric spacetimes
Creators: name: Camci, Ugur
name: Qadir, Asghar
name: Saifullah, K.
Publisher: name: arXiv
Year: 2010
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: Conformal Ricci collineations of static spherically symmetric spacetimes are studied. The general form of the vector fields generating conformal Ricci collineations is found when the Ricci tensor is non-degenerate, in which case the number of independent conformal Ricci collineations is \emph{fifteen}; the maximum number for 4-dimensional manifolds. In the degenerate case it is found that the static spherically symmetric spacetimes always have an infinite number of conformal Ricci collineations. Some examples are provided which admit non-trivial conformal Ricci collineations, and perfect fluid source of the matter.
Enzymology of the xyloglucan utilization system in the soil saprophyte Cellvibrio japonicus
Creators: name: Attia, Mohamed Awad AbdElKader
Publisher: name: University of British Columbia
Year: 2018

description: Xyloglucan (XyG) is a ubiquitous plant heteropolysaccharide representing up to one-quarter of the total carbohydrate content of terrestrial plant cell walls. Given its structural complexity, XyG requires a consortium of backbone-cleaving endo-xyloglucanases and sidechain-cleaving exo-glycosidases for complete saccharification. The Gram-negative soil saprophyte Cellvibrio japonicus is a treasure trove for carbohydrate active enzymes (CAZymes) due to its robust capacity to degrade different plant polysaccharides. The XyG utilization machinery in C. japonicus is incompletely understood, despite recent characterization of associated sidechain-cleaving exo-glycosidases. I present here my attempts to identify and functionally characterize the endo-xyloglucanase(s) and the XyG-specific β-1,4 exo-glucosidase catalyzing the first and final steps, respectively, in the XyG saccharification pathway in C. japonicus. Bioinformatic analysis identified one Glycoside Hydrolase Family 74 (CjGH74), three GH5_4 (CjGH5D, CjGH5E and CjGH5F) and three GH9 (CjGH9A, CjGH9B and CjGH9C) candidates with putative endo-xyloglucanase activity. Biochemical and structural analyses that involved CjGH74 and the three CjGH5_4 enzymes clearly demonstrated the exquisite specificity of the four enzymes towards XyG. Scrutiny of the modular architecture of the CjGH5_4 enzyme, CjGH5F, identified the module of unknown function X181. Affinity gel electrophoresis and isothermal titration calorimetry identified the X181 module as a member of a new CBM family that exclusively binds galactose-containing polysaccharides including XyG and galactomannans, congruent with the displayed endo-xyloglucanase activity of the pendent catalytic domain. Surprisingly, reverse genetic analysis in C. japonicus displayed the lack of growth perturbation on XyG upon the deletion of the four specific endo-xyloglucanases, suggesting the presence of other enzyme(s) with potential endo-xyloglucanase activity. Biochemical characterization of the GH9 enzyme CjGH9B revealed its high catalytic efficiency towards mixed linkage β-glucan and its weak side-activity against xyloglucan, which might be sufficient to rescue the quadruple deletion mutant. Bioinformatic analysis identified the four CjGH3 enzymes Bgl3A, Bgl3B, Bgl3C, and Bgl3D as potential targets for the XyG-specific exo-β-glucosidase in C. japonicus. Comprehensive genetic and biochemical approaches interestingly revealed the fundamental contribution of Bgl3D in XyG utilization in C. japonicus. Together, these data shed light on the initial and final steps of xyloglucan saccharification in C. japonicus and identify useful enzymes for selective biomass deconstruction.
Online Supplement for Han et al. (2023)
Creators: name: Han, Jung-Hoon
name: Pollock, Timothy G.
name: Graffin, Scott D.
Publisher: name: figshare
Year: 2023
Subjects: Organisation and management theory

description: Online supplement for the manuscript: Han, Jung-Hoon, Timothy G. Pollock, & Scott d. Graffin. 2023. Now You See Me: How Status and Categorical Proximity Shape Misconduct Scandalization. Academy of Management Journal, Forthcoming.
 Please refer to the manuscript for detailed explanations of the tables.
Evolution of X-ray and FUV Disk-Dispersing Radiation Fields
Creators: name: Ingleby, Laura
name: Calvet, Nuria
name: Hernandez, Jesus
name: Briceno, Cesar
name: Espaillat, Catherine
name: Miller, Jon
name: Bergin, Edwin
name: Hartmann, Lee
Publisher: name: arXiv
Year: 2011
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present new X-ray and Far Ultraviolet (FUV) observations of T Tauri stars covering the age range 1 to 10 Myr. Our goals are to observationally constrain the intensity of radiation fields responsible for evaporating gas from the circumstellar disk and to assess the feasibility of current photoevaporation models, focusing on X-ray and UV radiation. We greatly increase the number of 7-10 Myr old T Tauri stars observed in the X-rays by including observations of the well populated 25 Ori aggregate in the Orion OB1a subassociation. With these new 7-10 Myr objects, we confirm that X-ray emission remains constant from 1-10 Myr. We also show, for the first time, observational evidence for the evolution of FUV radiation fields with a sample of 56 accreting and non-accreting young stars spanning 1 Myr to 1 Gyr. We find that the FUV emission decreases on timescales consistent with the decline of accretion in classical T Tauri stars until reaching the chromospheric level in weak T Tauri stars and debris disks. Overall, we find that the observed strength of high energy radiation is consistent with that required by photoevaporation models to dissipate the disks in timescales of approximately 10 Myr. Finally, we find that the high energy fields that affect gas evolution are not similarly affecting dust evolution; in particular, we find that disks with inner clearings, the transitional disks, have similar levels of FUV emission as full disks.
description: 41 pages, 12 figures
Realization of AlGaAs antidot arrays by pulsed laser interference gratings
Creators: name: Nebel, C. N.
name: Rogg, J.
name: Kelly, M. K.
name: Dahlheimer, B.
name: Rother, M.
name: Bichler, Max
name: Wegscheider, Werner
name: Stutzmann, M.
Publisher: name: Universität Regensburg
Year: 1997
Subjects: subject: 530 Physik

description: AlGaAs antidot arrays with about 107 antidots are produced by single-shot interference processing with a pulsed high-power Nd:YAG laser system. We apply magnetotransport experiments and atomic force microscopy (AFM) to explore the electronic and geometric properties of the arrays. The size of the antidot arrays are 3 mm × 3 mm and the period varies from 400 to 1000 nm. The dots are elliptic or circular and have diameters ranging from 255 to 690 nm. The magnetotransport experiments are performed at 1.5 K in van der Pauw contact configuration. The laser structuring leaves the two dimensional electron density nearly unchanged but decreases the mobility by a factor of about 30. Several maxima are detected in the low magnetic field magnetoresistivity which are discussed based on the geometric data determined by AFM.