cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Symphonies of Mother and Child
Creators: name: Pon, Nova
Publisher: name: University of British Columbia
Year: 2023

description: Symphonies of Mother and Child is a 40-minute composition written for a chamber orchestra of 15 players: flute (doubling piccolo and alto flute), oboe (doubling English horn), clarinet (doubling bass clarinet), bassoon, French horn, trumpet, trombone, percussion, piano (doubling toy glockenspiel), harp, two violins, viola, cello, and double bass. The work is in five movements and responds to the transformative experience of my bond with my child and broader insights it inspired on themes like attachment, interconnection, awareness, time, and transience. Along with the emotional evocations in the music, the work explores these ideas through the use of structural-expressive themes to integrate abstract concepts into musical structure. These include: smallness and simplicity, coherent complexity, special states of awareness, sensitive interactions, time and transience, and expressive trajectories. The piece also contains cyclic materials that recur in multiple movements, including a five-phrase Long theme that leads to movements 1, 3, 4, and 5 being structured into five sections. Movement 1, entrancement, unfolds the mystery of the new life through waking dreams and reflective slumber. In movement 2, following, echoing round songs stratify and shift in a musical metaphor for learning to attune. The third movement, explore and implore, playfully and nostalgically responds to connection and separation as the child grows up and away. Movement 4, listening, meditates on awareness and interconnection between mother, child, and a wilderness of birds and earth. In movement 5, eternity’s sun rise, reflection and exuberant motion forward meet as the past, present, and future come together. The first chapter of this supporting document describes my background and recent composing directions, my transformative mother-child experience, and literature and influences related to the piece. The second chapter overviews the piece including the definition of structural expressive themes, their use in my past works and the current piece, and the overall piece structure and recurring cyclic materials. Chapters 3-7 cover approaches and analyses for movements 1-5 respectively. Chapter 8 contains closing remarks. Chapter 9 contains the musical score for Symphonies of Mother and Child, including a program note. Further details on the music are provided in the Appendices.
Toward Better Health Care for Rural Americans
Creators: name: Davis, Karen
name: Marshall, Ray
Publisher: name: Ray Marshall Center for the Study of Human Resources
Year: 1976
Subjects: Other Health and Human Services

description: Testimony prepared for the U. S. Senate Subcommittee on Rural Development, Hearings on Rural Health Care. Few problems are more important to rural people than adequate health care. Despite the myth that rural people universally enjoy good health, solid evidence to the contrary exists. Infant mortality rates are as high as 70 percent above the national average in selected rural areas. Age adjusted death rates are higher in non metropolitan areas than metropolitan areas, and have been declining at a slower rate in rural areas than in urban areas.
Relationships among Inorganic Arsenic, Nutritional Status CpG Methylation and microRNAs: A Review of the Literature
Creators: name: Venkatratnam, A.
name: Fry, R.C.
name: Marable, C.A.
name: Keshava, A.M.
Publisher: name: SAGE Publications Inc.
Year: 2021

description: Inorganic arsenic is a naturally occurring toxicant that poses a significant and persistent challenge to public health. The World Health Organization has identified many geographical regions where inorganic arsenic levels exceed safe limits in drinking water. Numerous epidemiological studies have associated exposure to inorganic arsenic with increased risk of adverse health outcomes. Randomized clinical trials have shown that nutritional supplementation can mitigate or reduce exacerbation of exposure-related effects. Although a growing body of evidence suggests that epigenetic status influences toxicity, the relationships among environmental exposure to arsenic, nutrition, and the epigenome are not well detailed. This review provides a comprehensive summary of findings from human, rodent, and in vitro studies highlighting these interactive relationships.
Impact of mixing and curing temperatures on fresh and hardened states properties of UHPC
Creators: name: Androuet, Cedric
name: Deaux, Olivier
name: Charron, Jean-Philippe
Publisher: name: figshare
Year: 2022
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering
subject: 90503 Construction Materials
subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: New Canadian and American standards for concrete and bridges now provide guidelines for the design, production, curing, material characterization and installation of Ultra-High Performance Fiber Reinforced Concretes (named UHPFRC or UHPC) on structures. However, some technical aspects require more research since fundamental knowledge about UHPC is not as complete as for normal strength concretes (NSC). Among these aspects, knowledge on the properties of UHPC produced under field conditions is scarce. The main goal of the research project was to evaluate the fresh state properties (slump flow, air content, mass density, hydration heat) and hardened state properties (elastic modulus, Poisson ratio, compressive and flexural strengths) of a UHPC subjected to various mixing temperatures (10, 20 and 30°C) and curing temperatures (10, 23 and 35°C) encountered in field conditions. The impact of mixing and curing temperatures on each property is discussed and practical information is provided to help engineers planning the UHPC curing duration and formwork stripping.
Development and characterization of the anode-free lithium metal battery electrode
Creators: name: Zhou, Bingxin
Publisher: name: University of British Columbia
Year: 2023

description: Although great effort has been devoted to the investigation of lithium metal batteries (LMBs) and numerous papers are published, the deposition and corrosion behavior of lithium is still not fully understood and requires further investigations. Moreover, the characterization and data interpretation in the literature can be very misleading or ambiguous. In this thesis, the deposition behavior of lithium at a carbon host, the decoupling of impedance of the solid-electrolyte interface (SEI) and plated lithium, and the impact of electrolytes on the lithium corrosion behavior are presented. Firstly, pure hollow core-carbon spheres (PHCCSs) are prepared and applied onto the Cu current collector, which is then used to investigate the deposition behavior of lithium. This type of structure is selected because the nano-carbon-based materials are widely reported as lithium host materials in LMBs, while contradictory claims are reported as to where the lithium plating occurs. It is demonstrated that the lithium shows some initial and limited intercalation into the PHCCSs and then plates on the external carbon walls and the top surface of the carbon coating during the charging process. No evidence of lithium plating inside the hollow core space is found. Secondly, a combined electrochemical quartz crystal microbalance (EQCM) and electrochemical impedance spectroscopy (EIS) study is conducted to decouple the various contributions to the impedance response of an anode free battery. This decoupling is achieved by a comparison of the evolution of EIS spectra in 2- and 3- electrode cells during the Li plating/striping processes. The observed high and low frequency loops of the impedance spectra can be unambiguously assigned to the charge transfer of the SEI and the plated lithium layers, respectively. Finally, inspired by the capacity performance in the lithium bis(fluorosulfonyl)imide- lithium bis(trifluoromethanesulfonyl)imide-dimethyl ether-dioxolane (LiFSI-LiTFSI-DME-DOL) electrolyte system, the impact of electrolytes on lithium corrosion behavior is investigated systematically. Results show the key point of minimizing capacity loss during open circuit voltage (OCV) is the coordination of insoluble particles and polymers in the SEI layer. A “less-soluble particle-polymer symbiosis” (LSPPS) concept is thus proposed and validated by the preparation and performance evaluation of modified electrolytes.
title: System
title: Warum systemisches Denken und Handeln gut zu sozialer Innovation und nachhaltiger Transformation passen
titleType: AlternativeTitle
Creators: name: Stein, Ursula
Publisher: name: Wien
Year: 2024
Subjects: Nachhaltige Stadtentwicklung
Soziale Innovation
Klimaneutrale Stadt
Transformation

description: In der Planungswissenschaft, in Planungsstudiengängen und in der Praxis räumlicher Planung dominiert seit Langem ein technisch-naturwissenschaftliches Verständnis der Begriffe System und systemisch. Diese Tradition ist unverzichtbar, denn räumliche Entwicklung ist z. B. ohne die Arbeit mit technischen, komplexen Strukturen und Modellen nicht denkbar. Sie hat aber eine Schwäche: Sie denkt Systeme mechanisch und hat Schwierigkeiten, die Unwägbarkeit und Kreativität von Menschen einzubeziehen. Für die gewollte Transformation zu nachhaltigen Wirtschafts- und Lebensweisen ist zusätzlich ein sozialer Systembegriff nötig, der heute überwiegend im Zusammenhang mit konstruktivistischen Gedanken verwendet wird und auf die Individualität, Wirklichkeitskonstruktion und Selbststeuerung von Akteurssystemen aufmerksam macht. Arbeitet man mit Menschen, Gruppen und Institutionen, hilft systemisch-konstruktivistisch geprägtes Arbeiten dabei, Menschen zu motivieren, eigenen Einfluss zu relativieren und dann passender zu gestalten, Lernen und Reflexion Platz zu geben und für stets mögliche Überraschungen gewappnet zu sein.
Bridging Endocrine Therapy for HR+/HER2- Resectable Breast Cancer: Is it Safe?
Creators: name: Ollila, D.W.
name: Thornton, M.
name: Park, J.
name: Iles, K.A.
name: Gallagher, K.
name: Spanheimer, P.M.
name: Roberson, M.
Publisher: name: SAGE Publications Inc.
Year: 2021

description: Background: The COVID-19 pandemic has required new treatment paradigms to limit exposures and optimize hospital resources, including the use of neoadjuvant endocrine therapy (NAET) as bridging therapy for HR+/HER2-invasive tumors and DCIS. While this approach has been used in locally advanced disease, it is unclear how it may affect outcomes in resectable HR+/HER2- tumors. Methods: Women ≥18 years diagnosed with in situ (Tis) or non-metastatic HR+/HER2- breast cancer from March-May 2019 and 2020 were included. Fisher’s exact test and two-sample t test were used to compare baseline characteristics and surgical outcomes between strata. Sub-analysis was performed between patients who received primary surgery vs a bridging NAET approach. Results: Despite similar clinical characteristics, patients in 2019 were more likely to have a surgery-first approach (75% vs 42%, P-value =.0007), receive surgery sooner (22 vs 29 days, P-value <.001), and within 60 days from diagnosis date (100% vs 85%, P-value =.0301). Neoadjuvant endocrine therapy was a more prevalent approach in 2020 (48% vs 7%, P-value <.0001). Rates of clinical to pathologic up-staging remained consistent across primary surgery vs bridging NAET subgroups (P-value =.9253). Discussion: Pandemic-driven treatment protocols provide a unique opportunity to assess the utility of bridging endocrine therapy for resectable HR+/HER2- tumors. Differences in clinical and pathologic staging were similar across groups and did not appear to be affected by receipt of NAET. Our limited cohort demonstrates this strategic therapeutic avenue can optimize health care utilization and may be a reasonable approach when delaying surgery is preferred.
Experimental evolution of species ranges and coexistence using competing duckweed species
Creators: name: Usui, Takuji
Publisher: name: University of British Columbia
Year: 2023

description: Understanding the evolution of species distributions is a fundamental goal of evolutionary ecology. With global change comes new challenges in predicting the movement of species ranges and the re-assembly of ecological communities. Importantly, these rapid changes in species distributions can provide unique opportunities for ecology to shape evolution, and for evolution to govern population and community dynamics across space and time. However, much remains unknown about how rapid feedbacks between population ecology and genetics (i.e., eco-evolutionary feedbacks) scale up to govern species distributions and community patterns. To make progress, this thesis tests a series of predictions on how evolution can alter species distributions and community assembly, using the evolution of duckweed species in experimental mesocosms. In Chapter 2, I test how evolution during range expansion alters our ability to predict population spread. With selection from an environmental gradient in space, I found that range expansion speed was more variable, and hence less predictable, across replicate populations. This occurred despite slower population spread and higher population densities at the range front – conditions in which models otherwise predict less variable range expansion speeds due to greater selection over genetic drift. In Chapter 3, I test how community context, specifically interspecific competition, alters adaptation during climate-driven range shifts. I found feedbacks between competition and evolution differed across a species experimental range, with competition limiting adaptive evolution at the range core, but promoting adaptation to climate stress at the range edge. I suggest that competition therefore has the potential to promote evolutionary rescue in response to global change. Lastly, in Chapter 4, I test whether and how mechanisms of coexistence evolve over time, from identical lineages to distinct species. I parametrized coexistence of genetically divergent lineages within and across duckweed species to show that coexistence mechanisms evolve in concert with lineage divergence. While evolutionary biology has mainly focused on mechanisms of genetic isolation, I suggest that feedbacks between genetic isolation and ecological differentiation is key for the origins of coexisting species. Overall, my thesis unpacks the diverse, and often surprising, pathways by which eco-evolutionary feedbacks govern population and community trajectories across space and time.
AARP 50+ Coronavirus Study: Wave 1
Creators: name: American Association Of Retired Persons (AARP)
Publisher: name: Roper Center for Public Opinion Research
Year: 2022

description: Concern about contracting coronavirus (3); diagnosed/tested positive for coronavirus (3); modified behavior/plans due to coronavirus (14); informed about guidelines for prevention of coronavirus spread (1); following guidelines for prevention of coronavirus spread (1); concerns about dying from the coronavirus (1); financial concerns about coronavirus (10); concern about coronavirus scams (1); concern about consumer goods shortages (1); concern about social isolation/loneliness (1); financial impacts of coronavirus experienced (7); information sources about coronavirus (13); trustworthiness of information sources (16); ways of coping with the coronavirus pandemic (9); familiarity with major health organizations (3); provided unpaid care to a relative or friends in the past 12 months (1).
The impact of pathological narcissism on change in symptoms, life satisfaction, and work and social impairment in psychodynamic group therapy for perfectionism
Creators: name: Ge, Sabrina Yue Jia
Publisher: name: University of British Columbia
Year: 2023

description: Background: Several decades of theory suggest that pathological narcissism may limit psychotherapy success, but empirical evidence for such theories is limited and mixed. In addition, despite theoretical and empirical associations between pathological narcissism and perfectionism, no studies thus far have investigated the impact of pathological narcissism on psychotherapy outcome for patients with perfectionism. Thus, this study aimed to extend past research by investigating whether pre-treatment pathological narcissism led to smaller pre- to post-treatment reductions in 1) symptom severity, 2) life satisfaction and, 3) work and social functioning in a sample of patients with perfectionism undergoing group psychodynamic psychotherapy. Method: This sample was drawn from the UBC Perfectionism Treatment Study (Hewitt et al., 2023) and consisted of 80 treatment-seeking adults with elevated perfectionism. Patients underwent 12 sessions of psychodynamic group psychotherapy for perfectionism and completed self-report measures of pathological narcissism at pre-treatment and of symptom severity, life satisfaction, and work and social impairment at pre- and post-treatment. Results: Contrary to expectations, multilevel and multiple regression analyses indicated that pre-treatment pathological narcissism did not significantly predict post-treatment changes in symptom severity, life satisfaction or work and social impairment. Additional analyses showed that these findings held even when vulnerable and grandiose dimensions of pathological narcissism were analyzed separately. Conclusions: Despite longstanding theoretical and clinical accounts on the perniciousness of pathological narcissism in the clinical context, these results, taken together with past findings, suggest that pathological narcissism may not be associated with poorer psychotherapy outcomes in certain contexts, such as in the case of psychodynamic group psychotherapy for perfectionism. Future research should investigate whether certain variables may moderate the relationship between pathological narcissism and treatment outcome.
title: Schnittstelle Mensch-Fahrzeug: Forschung an der TUD
Creators: name: Schaub, Karlheinz
name: Abendroth, Bettina
Publisher: name: VDI Bezirksverein Frankfurt-Darmstadt e.V.
Year: 2023

description: Um mit der Gestaltung einzelner Komponenten im Fahrzeug eine Verbesserung des gesamten Systems Fahrer-Fahrzeug-Umwelt im Hinblick auf Sicherheit, Komfort und Akzeptanz zu erzielen, müssen die Auswirkungen auf die Schnittstelle Mensch-Fahrzeug berücksichtigt werden. Das Institut für Arbeitswissenschaft an der TU Darmstadt (IAD) setzt den Schwerpunkt der Forschungsarbeiten, die zu einem erheblichen Teil von der Automobilindustrie beauftragt werden, auf die Durchführung und Analyse von Fahrversuchen mit Probanden im öffentlichen Straßenverkehr, auf einem Testgelände oder im eigenen Fahrsimulator.
title: Planung
title: Von sozialen Innovationen zur Transformation in der räumlichen Planung?
titleType: AlternativeTitle
Creators: name: Jessen, Johann
name: Zupan, Daniela
Publisher: name: Wien
Year: 2024
Subjects: Nachhaltige Stadtentwicklung
Soziale Innovation
Klimaneutrale Stadt
Transformation

description: Mit dem Ziel einer klimagerechten Stadtentwicklung werden auch die raumbezogenen Fachdisziplinen, inklusive der räumlichen Planung, direkt in ihrer Verantwortung adressiert und sind aufgerufen, ihre bisherige Praxis grundlegend zu überdenken. Doch wie kann die dringend notwendige Erneuerung, die ein ganzes Bündel anspruchs- und voraussetzungsvoller, ineinander verflochtener und sich teilweise widersprechender Einzelerneuerungen umfasst, gelingen? Der Beitrag greift diese Frage auf, indem er zunächst einige zentrale Ergebnisse eines Forschungsprojektes vorstellt, das eine analytisch-retrospektive Untersuchung sozialer Innovationen in der räumlichen Planung zum Ziel hatte. Sodann wenden wir die dabei gewonnenen Erkenntnisse prospektiv und verdichten sie zu drei übergreifenden Einsichten, die sich für normativ-zukunftsgewandte Erneuerungsprozesse hin zu einer nachhaltigen urbanen Transformation als nützlich erweisen könnten.
Working Collections: Preserving Memory, Enhancing Heritage
Creators: name: Ward, Sandi
name: Ward, Sandi
Publisher: name: Digital Repository at the University of Maryland
Year: 2019
Subjects: oral history
China
Cultural Revolution
special collections
archives
born digital
Chinese
文化大革命
中国现当代历史
口述历史

description: Presentation by Sandi Ward for "Working Collections: Preserving Memory, Enhancing Heritage" at MARAC Morgantown, April 2019. The CR/10 Project (CR/10) is a video oral history project created by the East Asian Library, University Library System, University of Pittsburgh. CR/10 aims to preserve memories and impressions from people who experienced China's Great Proletarian Cultural Revolution, which lasted from 1966-1976. The collection also includes interviews with members of China's post-Cultural Revolution generations, who reflect on the circumstances under which they did, or did not, learn about the Cultural Revolution. Interviewees are given approximately 10 minutes to express their memories of or thoughts about the 10 years of China's Cultural Revolution. This presentation discussed the motivations of the project, its workflow and technical details, and its reception by researchers, faculty, and the public.
title: Functional movement disorders
title: Exploring lived experiences and psychological interventions.
titleType: Subtitle
Creators: name: Bazydlo, Sylwia
Publisher: name: Lancaster University
Year: 2021
Subjects: functional neurological disorder
functional movement disorder
psychogenic movement disorders
psychological interventions for functional movement disorders

description: This thesis examines issues related to functional movement disorders (FMD) and consists of three papers: a literature review, a research paper and a critical appraisal of the research process. The scoping literature review explored the characteristics of psychological interventions for FMD in research studies in the last 20 years. It found that FMD was conceptualised differently across the studies and interventions employed various techniques to target different assumed FMD mechanisms. The review identified that although psychological wellbeing, co-morbid physical symptoms and quality of life are important factors influencing and influenced by FMD, they are often not monitored in research studies. Acceptability of the interventions has also not been measured despite preliminary evidence of their low uptake and high dissatisfaction with psychological explanations of FMD. A number of recommendations have been made for future studies to improve design and evaluation of psychological interventions for this population. The research paper explored lived experiences of people with FMD. Ten semi-structured interviews were analysed using Interpretative Phenomenological Analysis. Three superordinate themes were generated: (1) The tug of war with the secret agent within: the power struggle with symptoms; (2) Navigating risks of disclosing the diagnosis: stigma and self-preservation (3) Pursuing hope, knowledge and treatments against helplessness and passivity. The findings indicate that people with FMD may face many internal and interpersonal battles whilst trying to maintain hope, a sense of control and identity. A sense of oppression, loss of control and stigma were explained in the context of discriminatory power distribution in the society and healthcare settings. Recommendations for research and clinical practice focus on facilitating patients’ empowerment and access to adequate treatments in FMD-informed services. The critical appraisal discusses the studies’ finding in the context of interpersonal and systemic power dynamics and reflects on the research process from critical theory perspective.
ความต้องการการเรียนรู้ตลอดชีวิตของผู้สูงอายุในเขตภาคเหนือตอนบน
Creators: name: จิตนธี ริชชี่
name: กนกพร สัยยะสิทธิพานิชย์
Publisher: name: วารสารมหาวิทยาลัยพายัพ
Year: 2023
Subjects: การเรียนรู้ตลอดชีวิต
ผู้สูงอายุ
ภาคเหนือตอนบน

description: วารสารมหาวิทยาลัยพายัพ, 33, 2, 1
ระดับความพึงพอใจของผู้บริโภคต่อการให้บริการยานพาหนะผ่านแอปพลิเคชัน ในเขตภาคเหนือตอนบน
Creators: name: ศรัณย์ ภูดล
name: ธีราลักษณ์ สัจจะวาที
name: สุพรรษา ลอรี่
name: อภิญญา กาน้อย
name: อัศมา แซ่ลิ้ว
Publisher: name: วารสารมหาวิทยาลัยพายัพ
Year: 2023
Subjects: ความพึงพอใจ
ปัจจัยส่วนประสมทางการตลาด
การให้บริการ
บริการยานพาหนะ
แอปพลิเคชัน

description: วารสารมหาวิทยาลัยพายัพ, 33, 2, 18
An Ambulatory Electronic Diary Study of Reward Competition
Creators: name: Cummings, Jenna
name: Mamtora, Tanvi
name: Tomiyama, A.
name: Schiestl, Emma
name: Gearhardt, Ashley
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: This preregistration describes plans for a secondary data analysis of data from "An Ambulatory Electronic Diary Study of Reward Competition."
Чўлпон поэтикаси (насрий асарлари асосида)
Creators: name: Куронов, Дилмурод Хайдаралиевич
Publisher: name: Zenodo
Year: 1998

description: Чўлпон насрий асарларининг поэтик хусусиятлари тадқиқ этилган.
ปัจจัยที่มีอิทธิพลต่อพฤติกรรมการพิทักษ์สิทธิ์ส่วนบุคคลของเด็กและเยาวชน อำเภอเมือง จังหวัดเชียงใหม่
Creators: name: จุฑามาศ สีธิ
name: วีรวรรณ วงศ์ปิ่นเพ็ชร์
Publisher: name: วารสารมหาวิทยาลัยพายัพ
Year: 2023
Subjects: พฤติกรรมการพิทักษ์สิทธิ์ส่วนบุคคล
เด็กและเยาวชน
การสนับสนุนทางสังคม
การเห็นคุณค่าในตนเอง

description: วารสารมหาวิทยาลัยพายัพ, 33, 2, 33
Synthese, in vitro und in vivo Evaluierung molekularer Sonden, PROTACs und PET-Tracern zur Adressierung der Proteinkinase Akt
Creators: name: Lindemann, Marius
Publisher: name: TU Dortmund
Year: 2022
Subjects: subject: Molekulare Sonden
subject: PROTAC
subject: PET-Tracer
subject: Medizinalchemische Adressierung der Proteinkinase Akt
subject: 570
subject: 540
subject: Tumor
subject: Proteinkinasen

description: Tumorerkrankungen stellen weltweit die zweithäufigste Todesursache dar und aufgrund der demographischen Entwicklung nimmt die Anzahl der Neuerkrankungen und Todesfälle stetig zu. Zur Adressierung der Proteinkinase Akt, ein hochrelevantes Protein in der Tumorentstehung, wurde für die präklinische Entwicklung die Hochskalierung eines kovalent-allosterischen Akt Inhibitor (CAAI) durchgeführt. Hiermit konnten in ersten Xenograft-Modellen vielversprechende Ergebnisse erhalten werden. Zur Optimierung der PK-Eigenschaften dieses CAAI wurde der chemische Raum erweitert. Die kleine fokussierte Substanzbibliothek auf Basis eines monozyklischen Pyridins lieferte neue Einblicke in die SAR der CAAIs. Dies ermöglichte das Design und die Synthese eines Akt-spezifischen Radioliganden, welcher in ersten in vivo Tiermodellen ein stabiles radioaktives Signal induzierte und durch weitere Optimierung zur Entwicklung eines PET-Tracers beitragen kann. Zur genaueren Analyse der Tumorbiologie von Akt wurden molekulare Sonden auf Basis der CAAIs entwickelt und in vitro etabliert. Als neuer innovativer Adressierungsansatz konnten erfolgreich die ersten drei Akt-spezifischen allosterischen PROTACs dargestellt werden, die einen Akt1-Abbau in Panc1-Zellen induzierten.
description: Tumor diseases represent the second leading cause of death worldwide and due to demographic trends the number of new cases and deaths is steadily increasing. To address the protein kinase Akt, a highly relevant protein in tumorigenesis, upscaling of a covalent-allosteric Akt inhibitor (CAAI) was performed for preclinical development. Promising results were obtained with this in initial xenograft models. To optimize the PK properties of this CAAI, the chemical space was expanded. The small focused compound library based on a monocyclic pyridine provided new insights into the SAR of CAAIs. This enabled the design and synthesis of an Akt-specific radioligand, which induced a stable radioactive signal in initial in vivo animal models and may contribute to the development of a PET tracer through further optimization. For a more detailed analysis of Akt tumor biology, molecular probes based on CAAIs were developed and established in vitro. As a new innovative targeting approach, the first three Akt-specific allosteric PROTACs were successfully displayed, which induced Akt1 degradation in Panc1 cells.
title: Screening the commune
title: Popular tele/visions of domestic discontent
titleType: Subtitle
Creators: name: Lawrence, Will
Publisher: name: Lancaster University
Year: 2021

description: This thesis investigates the phenomenon of communes being brought to life as a device and setting in popular television narratives between the mid-2000s and the late-2010s. I ask: how is the commune imagined on popular television of this period? Why does the commune have imaginary vitality at this juncture? I explore the imaginary vitality of the commune in the context of what I call a “decade of domestic discontent”: a period of discontent and unease in contemporary life regarding matters of the domestic. The “domestic discontent” to which I refer corresponds with concerns about climate change, intergenerational inequalities, and sexual politics. I examine four case study television programmes that feature particularly notable instances of the commune’s animation in the mid-2000s to late-2010s. I deploy a “figurative” analysis, in which a key focus of analytical attention is the fictional characters or factual television participants that feature in narratives about communes. I explore how these characters are constructed as having intertextual characteristics and qualities such that they bring to life figures that circulate in wider culture. The set of figures that I identify as imaginatively bound up with the commune are: “the low impact pioneer”, “the boomerang child”, “the selfish feminist”, “the cult leader”, “the acid casualty”, and “the raving brute”. This set of figures, I argue, is made up of both “discontented figures” and “figures of discontent”, that is, figures that express various kinds of discontent and figures that are objects of discontent. I argue that the commune is a signifier of multifarious kinds of discontent that have particular resonance in the contemporary moment. The thesis highlights television narratives featuring communes as presenting scenarios that evoke some of the most pressing current issues of domestic discontent.
การส่งเสริมการใช้ระบบเทคโนโลยีสารสนเทศเพื่อการบริหารงานงบประมาณของโรงเรียนบ้านนากลาง
Creators: name: อภินันท์ อุตวงศ์
name: ประกอบ สาระวรรณ
name: ปรีชาชาญ อินทรชิต
Publisher: name: วารสารมหาวิทยาลัยพายัพ
Year: 2023
Subjects: การส่งเสริมการใช้ระบบเทคโนโลยีสารสนเทศ
การบริหารงานงบประมาณ
โรงเรียนบ้านนากลาง

description: วารสารมหาวิทยาลัยพายัพ, 33, 2, 47
Chapter 2: Evolutionary analysis of THAP9 transposase: conserved regions, novel motifs
Creators: name: Rashmi, Richa
Publisher: name: Zenodo
Year: 2022

description: THAP9 is a transposable element-derived gene that encodes the THAP9 protein, homologous to the Drosophila P-element transposase (DmTNP). However, the exact functional role of THAP9 is unknown. In this chapter, we perform evolutionary analysis and extensive in silico characterization of THAP9, including predicting domains and putative post-translational modification sites. We predicted previously unreported mammalian-specific post-translational modification sites that may play a role in the subcellular localization of THAP9. We also observe that although THAP9 has evolved under a strong pervasive purifying selection, yielding high conservation of THAP9, there are distinct class-specific conservation patterns of crucial functional residues in specific domains.
title: Resilienz
title: Konturen eines schillernden Konzeptes
titleType: AlternativeTitle
Creators: name: Kuhlike, Christian
Publisher: name: Wien
Year: 2024
Subjects: Nachhaltige Stadtentwicklung
Soziale Innovation
Klimaneutrale Stadt
Transformation

description: In den letzten Jahren hat sich der Begriff Resilienz in verschiedenen Kontexten etabliert; auch für die Gestaltung urbaner Entwicklungen gewinnt er an Bedeutung. Der Begriff wird von verschiedenen Disziplinen genutzt und ermöglicht den interdisziplinären Austausch, wobei sich im Wesentlichen zwei Perspektiven etabliert haben. Die erste betont die Fähigkeit zur Erholung nach einer Katastrophe sowie die Widerstandsfähigkeit von (urbanen) Systemen gegenüber Störungen. Die zweite betont die Fähigkeit zu Veränderung und Transformation. Die Debatte um eine resiliente urbane Entwicklung ist damit durch eine paradoxe Spannung geprägt: Auf der einen Seite wird die Bedeutung von Kontinuität und Stabilität betont, auf der anderen die Notwendigkeit von Veränderung und Transformation. In der deutschsprachigen Debatte hat sich die Wahrnehmung des Konzeptes in den letzten Jahren stark gewandelt. Während der Begriff Resilienz zunächst wenig präsent war, haben in den letzten Jahren zahlreiche Veröffentlichungen das Thema aufgegriffen. Dennoch wird Resilienz in der Verwaltungspraxis oft noch als fremd empfunden. Es stellt sich daher die Frage nach dem konkreten Mehrwert des Konzeptes im urbanen Kontext. Dieser Beitrag gibt einen kurzen Überblick zu wesentlichen Diskussionspunkten.
Leaky bodies reclaimed : biofluids, contagion, and Victorian England’s strange intimacies
Creators: name: MacDonald, Anna E.
Publisher: name: University of British Columbia
Year: 2023

description: This dissertation revisits Victorian representations of fallen women to reimagine their bodies as unexpected sites of liberatory possibility, and to reinscribe their biofluids as a medium through which nineteenth-century authors negotiate deep-seated questions of material and symbolic relation. A major contribution of Victorian studies has been to recognize how narratives of fallenness served a regulatory function in the public management of England’s social body. These scholars investigate how this cultural figure exhibits the dangers of the body’s fluid, trans-corporeal flows. She thereby functions both as a cultural repository for Victorian contagion anxieties about epidemics, as well as a justification for the broader disciplinary mechanisms through which England managed the inputs and outputs of its citizens’ bodies. Spanning works of poetry and prose, each of my chapters reexamines one archetypal figure of Victorian fallenness: the drowned fallen woman, the poor seamstress, the fallen breastfeeder, and the lady poisoner. I investigate how nineteenth-century fictional and medical authors imaginatively interpolated these women’s bodily processes into epidemic diseases through a fluid that was metonymic to both: they join lubrication and cholera through water, menstruation and tuberculosis through blood, lactation and smallpox through milk, and vaginal discharge and syphilis through poison. Rather than attempt to disarticulate femininity from Victorian notions of fluidity and contagion, I explore one unexpectedly transgressive outcome of this correlation. I do so by examining a series of popular midcentury authors who use these leaky bodies to expand contagion narratives from sites of destructive to productive transformation. My thesis is that Victorian authors demonstrate a sophisticated understanding of fluidity that we tend to reserve for modern new materialist conceptualizations. My selected authors register a nineteenth-century attunement to the profound entanglements of material phenomena (humans, nonhuman animals, plants, minerals, chemicals) as well as a state of fluidity between material and symbolic phenomena (the latter encompassing feelings, affects, and words). These authors, moreover, deploy their attunement to fluidity towards expansive models of contact, communication, and community—forms of intimacy that emerge from (not despite) contagion’s destructive effects. Such models of fluidity anticipate new materialist conceptualizations of contagion in the post-Covid era.
title: Residential buildings as a flexibility component in the district network - Development of a modelling approach / Wohngebäude als Flexibilitätsbaustein im Quartiersverbund – Entwicklung eines Modellierungsansatzes
Creators: name: Bogischef, Lea
name: De-Borja-Torrejon, Manuel
name: Hemmerle, Claudia
Publisher: name: Technical University of Munich
Year: 2020
Subjects: Energy, Flexibility, District, Network, Modelling

description: An enormous flexibility potential for future energy supply systems lies within the thermal building mass. In order to represent this potential in district energy models, a suitable model has to be found. Various aspects support the need for segmentation of residential buildings into separate thermal zones. A systematic summary of the requirements regarding thermal models in the district context is given and the resulting modelling approach is discussed.
description: Conference paper. German version presented at 8th Conference of IBPSA Germany and Austria (Graz, 23-25.09.2020) and published in Monsberger, M., Hopfe, C.J., Krüger, M. & Passer, A. (Eds.). BauSIM 2020, 8th Conference of IBPSA Germany and Austria, 23-25- September 2020, Graz University of Technology, Austria, Proceedings. Graz: Technische Universität Graz, 2020. ISBN e-book 978-3-85125-786-1, DOI 10.3217/978-3-85125-786-1 (pp. 410-416). English version added a posteriori for the present document. This document is in conformity with the approval of the responsible editor of the mentioned Proceedings.

Link to the original conference proceedings: https://www.tugraz-verlag.at/gesamtverzeichnis/unkategorisiert/bausim-2020-8th-conference-of-ibpsa-germany-and-austria-ebook/
Impact of mixing and curing temperatures on UHPFRC properties
Creators: name: Charron, Jean-Philippe
name: Androuet, Cedric
name: Deaux, Olivier
Publisher: name: figshare
Year: 2022
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering
subject: 90503 Construction Materials
subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: First structural applications in ultra-high performances fiber reinforced concretes (UHPFRC) were mainly precast solutions, such as bridge components and architectural panels. In that context, most studies concerning the impact of temperature on UHPFRC properties concerned high curing temperatures feasible in precast industry where a high control of the production process can be obtained. More recent applications of UHPFRC concerned also cast-in-place solutions involving field-cast joints and thin repairs. Limited data is available on the impact of low to moderate mixing and curing temperatures found on construction sites. This paper describes a research project focused on the evaluation of fresh state and hardened properties of UHPFRC in realistic cast-in-place conditions. UHPFRC were produced between 10 to 30 °C and cured between 10 to 35 °C, measurements of slump flow, air content, density, compressive and bending strengths are presented and discussed.
แนวทางการบริหารหลักสูตรฐานสมรรถนะของผู้บริหารสถานศึกษาโรงเรียนนำร่องพื้นที่นวัตกรรม สำนักงานเขตพื้นที่การศึกษาประถมศึกษาเชียงใหม่ เขต 3
Creators: name: ก้องเกียรติ วงค์ทอง
name: ธีรภัทร ประสมสุข
Publisher: name: วารสารมหาวิทยาลัยพายัพ
Year: 2023
Subjects: การบริหารหลักสูตรฐานสมรรถนะ
สถานศึกษานำร่องพื้นที่นวัตกรรมการศึกษาของผู้บริหารสถานศึกษา

description: วารสารมหาวิทยาลัยพายัพ, 33, 2, 60
title: Soziales
title: Das Soziale und sozial sein – deskriptive und normative Elemente des Begriffs
titleType: AlternativeTitle
Creators: name: Brunner, Alexander
Publisher: name: Wien
Year: 2024
Subjects: Nachhaltige Stadtentwicklung
Soziale Innovation
Klimaneutrale Stadt
Transformation

description: Der Beitrag versucht eine Annäherung an das Begriffsfeld und den Phänomenbereich Sozial/sozial zunächst durch eine philosophisch-anthropologisch inspirierte Leseart, die einige Ideen zum Wesen des Sozialen aus der europäischen Kultur- und Geistesgeschichte aufgreift. Anschließend an diese ersten Ausführungen wird v. a. auf die Normativität des Sozialen Bezug genommen, mit Seitenblicken auf eine mögliche wertfreiere analytische und deskriptive Thematisierung. Zuletzt werden Überlegungen aus den aktuellen Diskursen zu sozialer Innovation aufgegriffen und kritisch und rückfragend zu den Ausführungen zu Sozial/sozial in Beziehung gesetzt.
แนวทางพัฒนาการบริหารงานพัสดุ คณะพัฒนาการท่องเที่ยว มหาวิทยาลัยแม่โจ้ อย่างมีประสิทธิภาพ
Creators: name: ปิยะพร แดงชาติ
Publisher: name: วารสารมหาวิทยาลัยพายัพ
Year: 2023
Subjects: แนวทางการพัฒนา
การบริหารงานพัสดุ
คณะพัฒนาการท่องเที่ยว
มหาวิทยาลัยแม่โจ้

description: วารสารมหาวิทยาลัยพายัพ, 33, 2, 78
Finding your place at school : momentary fit, state authenticity and academic experiences
Creators: name: Guo, Yingchi
Publisher: name: University of British Columbia
Year: 2023

description: Individuals have the tendency to approach or avoid a given situation, yet this choice may be implicitly influenced by one’s experience of fit to the environment. As proposed by the State Authenticity as Fit to Environment (SAFE) model, individuals tend to gravitate towards situations where they experience self-concept fit, goal fit, and/or social fit, composing a gestalt sense of state authenticity. With two experience sampling studies, this work aims to validate this key assertion of the SAFE model and examine its implications in academic settings. Study 1 validated that when people experienced self-concept fit, goal fit, and social fit in a given situation, they felt authentic to themselves. Notably, each type of fit was cued by distinctive contextual features, and uniquely predicted the gestalt sense of state authenticity. All three types of fit positively predicted individuals’ willingness to return to the current situation and state attachment to university. Self-concept fit and low social fit specifically predicted individual’s working memory capacity. In a conceptual replication of Study 1, Study 2 additionally demonstrated that in classes where students felt three types of fit, they reported higher class/self overlap and state attachment to their major. Study 2 also showed cumulative effects of fit and state authenticity on longer-term academic outcomes, such as major/university commitment and course grades. Furthermore, Study 2 yielded preliminary evidence indicating that experiences of marginalization had a dampening effect on individuals' overall sense of fit and authenticity. This work establishes a foundation for understanding students’ academic outcomes through the lens of the SAFE model, paving the way for examining the detrimental impacts of marginalization on self-segregation.
Development of a Screening Informatics System at the UNM Center for Molecular Discovery
Creators: name: Yang, Jeremy
name: Ursu, Oleg
name: Mathias, Stephen
name: Bologa, Cristian
name: Waller, Anna
name: Evangelisti, Annette
name: Záhoransky-Köhalmi, Gergely
name: Oprea, Tudor
Publisher: name: Zenodo
Year: 2012
Subjects: screening informatics
drug discovery
cheminformatics

description: Presented at the ACS National Meeting, San Diego, March 25-29, 2012.
ТЕОРЕТИКО-ЛИТЕРАТУРНЫЕ ИДЕИ РУССКИХ СИМВОЛИСТОВ И М.М. БАХТИН
Creators: name: Клинг Олег Алексеевич
Publisher: name: Новый филологический вестник
Year: 2020
Subjects: М.М. Бахтин; теория литературы; русские символисты; Вяч. Иванов; В.Я. Брюсов

description: Цель статьи – охарактеризовать влияние теоретико-литературного наследия русского символизма на теоретические воззрения М.М. Бахтина. Если формалисты, по их собственному признанию, решительно отбросили «мистику», то есть и философское начало при анализе художественных произведений, то Бахтин стал прямым продолжателем традиций русских символистов, уделявших внимание не только форме, но и семантике текста. Очевидно, что в 1920-е гг. Бахтин не раз возвращался к синтетизму теоретических выкладок символистов. Во многом благодаря Бахтину не прервалась линия русского философского литературоведения, которая в начале XX века получила сильную подпитку в лице Д.С. Мережковского, А. Белого, Вяч. Иванова и других символистов. В работе Бахтина «Искусство и ответственность» можно увидеть осмысление эстетических идей русских символистов. Здесь очевидно наличие перекличек со статьями символистов, в том числе Вяч. Иванова, о назначении поэта. В формировании эстетических взглядов раннего Бахтина вырисовывается еще одна линия – влияние на него В.Я. Брюсова. В работе раннего Бахтина «К философии поступка» мы найдем еще больше перекличек с символистами: это проявляется, в частности, в вопросе о роли индивидуализма, который находится, по мнению Бахтина, в антиномичных отношениях с жизнью и для других. Бахтину безусловно близки эстетика и миропонимание русских символистов. В этом тоже проявляется его сближение с синтетическим литературоведением символистов. Еще одна сквозная тема статьи «К философии искусства» – полемика с формалистами. В работах Бахтина 1920-х гг. «Автор и герой в эстетической деятельности», «К вопросам методологии эстетики словесного творчества» эти положения будут развиваться. В этой полемике Бахтин в очередной раз опирается на вторую составляющую теоретических трудов русских символистов – эстетику. Таким образом Бахтин, не отвергающий необходимости изучать форму произведения, продолжает традиции синтетического литературоведения символистов.
УРАЛЬСКИЕ ГОРЫ ИЛИ ТАБЛИЦА МЕНДЕЛЕЕВА. О предмете и методе истории русской литературы. Часть вторая
Creators: name: Баршт Константин Абрекович
Publisher: name: Новый филологический вестник
Year: 2020
Subjects: аксиология; повествование; пространственно-предметный мир; история литературы; зоны ответственности; система ценностей

description: В статье сформирована гипотеза об устойчивой связи между системой ценностей литературного персонажа, характером сюжетной событийности и окружающим его пространством, наполненным вещами и явлениями. Исходя из ценностной окрашенности любого фабульного факта или явления, формирующего событийный ряд в сюжете, выдвигается предположение о возможности строительства литературно-эстетической типологии на основе универсальной ценностной структуры, сформировавшейся естественным образом вокруг вопроса о цели и смысле существования человека и человечества. Предпосылкой совершения поступка литературным героем и формирования сюжетного события является набор условий, сформированных ценностными системами – его собственной и окружающих его людей. Окружение персонажа индексирует его онтолого-аксиологический статус, что позволяет уточнить свойства повествовательной модели произведения, добавляя новые сведения относительно актуальных условий формирования сюжетного события. Аргументом в пользу такой возможности является тот факт, что равным образом и в реальной действительности, и в художественном мире произведения наблюдается возникновение структур, организующих ценностный мир человека с центральной точкой в виде сакрального символа, ниже которого расположены гедонистический, социальный, физиологический и другие уровни бытия. В трансцедентальной реальности индивидуума формируются характерные концентрические круги, зоны его метафизической ответственности. Проблема в том, что ценностная система человека расположена и функционирует в его кругозоре, получая в реальной действительности значительный диапазон различных оценок, однако в эстетическом объекте пространственно-вещевое окружение выстроено автором в стратегическом соответствии с кругозором персонажа, что дает основания для строительства типологии, основанной на уровне удаленности / противоречия / совпадения / приближения и т.д. к сакральному центру ценностной системы, с помощью которой оказывается возможным описание литературы как непротиворечивой и цельной структуры.