cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
In silico design of multi-epitope-based peptide vaccine against SARS-CoV-2 using its spike protein
Creators: name: Mitra, Debarghya
name: Pandey, Janmejay
name: Jain, Alok
name: Swaroop, Shiv
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: SARS-CoV-2 has been efficient in ensuring that many countries are brought to a standstill. With repercussions ranging from rampant mortality, fear, paranoia, and economic recession, the virus has brought together countries to look at possible therapeutic countermeasures. With prophylactic interventions possibly months away from being particularly effective, a slew of measures and possibilities concerning the design of vaccines are being worked upon. We attempted a structure-based approach utilizing a combination of epitope prediction servers and Molecular dynamic (MD) simulations to develop a multi-epitope-based subunit vaccine that involves the two subunits of the spike glycoprotein of SARS-CoV-2 (S1 and S2) coupled with a substantially effective chimeric adjuvant to create stable vaccine constructs. The designed constructs were evaluated based on their docking with Toll-Like Receptor (TLR) 4. Our findings provide an epitope-based peptide fragment that can be a potential candidate for the development of a vaccine against SARS-CoV-2. Recent experimental studies based on determining immunodominant regions across the spike glycoprotein of SARS-CoV-2 indicate the presence of the predicted epitopes included in this study. Communicated by Ramaswamy H. Sarma
Sonnenfleckenzeichnung Nr. 24519.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 23.08.1974, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Targeting a conserved pocket (n-octyl-β-D–glucoside) on the dengue virus envelope protein by small bioactive molecule inhibitors
Creators: name: Naresh, P.
name: Selvaraj, A.
name: Sundar, P. Shyam
name: Murugesan, S.
name: Sathianarayanan, S.
name: K., Krishnan Namboori P.
name: Jubie, S.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Dengue virus enters the cell by receptor-mediated endocytosis followed by a viral envelope (DENVE) protein-mediated membrane fusion. A small detergent molecule n-octyl-β-D–glucoside (βOG) occupies the hydrophobic pocket which is located in the hinge region plays a major role in the rearrangement. It has been reported that mutations occurred in this binding pocket lead to the alterations of pH threshold for fusion. In addition to this event, the protonation of histidine residues present in the hydrophobic pocket would also impart the conformational change of the E protein evidence this pocket as a promising target. The present study identified novel cinnamic acid analogs as significant blockers of the hydrophobic pocket through molecular modeling studies against DENVE. A library of seventy-two analogs of cinnamic acid was undertaken for the discovery process of DENV inhibitors. A Molecular docking study was used to analyze the binding mechanism between these compounds and DENV followed by ADMET prediction. Binding energies were predicted by the MMGBSA study. The Molecular dynamic simulation was utilized to confirm the stability of potential compound binding. The compounds CA and SCA derivatives have been tested against HSV-1 & 2 viruses. From the computational results, the compounds CA1, CA2, SCA 60, SCA 57, SCA 37, SCA 58, and SCA 14 exhibited favorable interaction energy. The compounds have in-vitro antiviral activity; the results clearly indicate that the compounds showed the activity against both the viruses (HSV-1 & HSV-2). Our study provides valuable information on the discovery of small molecules DENVE inhibitors. Communicated by Ramaswamy H. Sarma
Sonnenfleckenzeichnung Nr. 24508.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 10.08.1974, erstellt von Johann Dürst
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung Nr. 24540.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 20.09.1974, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Itinerarios de deliberación ciudadana. El programa Presupuesto Participativo del Municipio de Rosario (Argentina)
Creators: name: Bloj, Cristina
Publisher: name: Ibero-Amerikanisches Institut (Berlin)
Year: 2014
Subjects: Antropología Social; Ciencia Política; Presupuesto Participativo; Ciudadanía; Argentina; Siglo XXI; Social Anthropology; Political Science; Citizenship; Participative Budget; 21th Century

description: El sistema Presupuesto Participativo está sindicado como una de las iniciativas más innovadoras de democratización de la gestión local y de ejercicio de una democracia participativa a escala de la ciudad. En Argentina despunta a partir del año 2002 en una coyuntura de profunda crisis político-institucional, de interpelación a las formas canónicas de representación. Luego de transitado el sexto año de implementación nos preguntamos en qué medida el programa exhibe capacidades para ampliar la participación ciudadana en los asuntos públicos, optimizar el control de gestión, fortalecer el tejido social y promover una revinculación Estado-sociedad.
Abstract
The Participative Budget system has been recognized as one of the most innovative initiatives for the democratization of local management and the exercise of participative democracy at the town level. In Argentina the program started in 2002, in the conjuncture of a profound political and institutional crisis. After being at work for six year the questions is: to what extent does the program shows the capability to expand citizens´ participation in the public affairs, to optimize the accountability, to strengthen the social network and to promote new links between State and society?
description: IBEROAMERICANA, Vol. 8, Núm. 32 (2008)
1898 en la prensa española de 1908, 1918 y 1928
Creators: name: Strosetzki, Christoph
Publisher: name: Ibero-Amerikanisches Institut (Berlin)
Year: 2014
Subjects: 1898; Prensa; España; Siglos XIX-XX; Press; Spain; 19th-20th Century

description: Los mecanismos de defensa descritos por el psicoanálisis juegan un papel para la prensa española de 1908, 1918 y 1928 en la superación del síndrome de 1898. Especialmente los mecanismos de defensa psicoanalíticos de la represión, la regresión, el aislamiento, la consideración de lo dado como inexistente, la proyección, la introyección, el giro contra la propia persona y la conversión en lo contrario juegan un papel importante para la prensa española en su proceso de superación del desastre de 1898.
Abstract
The defense mechanisms described by the psychoanalysis play an important role for the Spanish press of 1908, 1918 and 1928 in order to recover from the syndrome of 1898. Especially, the psychoanalytic defense mechanisms of repression, regression, isolation, denial, projection, introjection, devaluation and conversion are of particular importance for the Spanish press concerning its process of overcoming the disaster of 1898.
description: IBEROAMERICANA, Vol. 8, Núm. 32 (2008)
La ley del deseo: acerca de Una excursión a los indios ranqueles, de Lucio V. Mansilla
Creators: name: Monder, Samuel
Publisher: name: Ibero-Amerikanisches Institut (Berlin)
Year: 2014
Subjects: Lucio V. Mansilla; Literatura argentina; Filosofía política; Siglo XIX; Argentine Literature; Political Philosophy; 20th. Century

description: Lucio V. Mansilla fue soldado, escritor y fanático de la moda. No es sorprendente, entonces, que Una excursión a los indios ranqueles, su obra maestra, mezcle detalles de una atrevida campaña militar con consejos para verse bien a toda hora, aun en las extremas condiciones de la pampa argentina. En este ensayo, quisiera examinar el modo en que esta pasión por el estilo se relaciona con cierta ideología. En este sentido, argumentaré que el texto de Mansilla resulta solidario con cierta filosofía política, de acuerdo con la cual, las leyes de la sociedad civil, siendo meras convenciones, se encuentran fundadas en otras de orden “natural”.
Abstract
Lucio V. Mansilla was a soldier, a writer and a fashionist. Not surprisingly, An Expedition to the Ranquel Indians, his masterpiece, blends the details of a daring military campaign with expert advice on how to be cool and fashionable even in the most extreme conditions of the Argentinean backcountry. In this essay, I would like to examine the ways in which this passion for style is related to ideology. Thus, I argue that Mansilla’s book is instrumental to a political philosophy, which holds that the laws of a civil society, being merely conventional, are founded on “natural” laws.
description: IBEROAMERICANA, Vol. 8, Núm. 32 (2008)
UNVEIL-ing Framework to Summer Research Experiences
Creators: name: Gonzalez, Wilnelia
Publisher: name: QUBES Educational Resources
Year: 2022

description: Undergraduate research opportunities help foster a science identity and increase retention in STEM majors and transition into the STEM workforce. Moreover, these opportunities have stronger results for underrepresented minority students in STEM. However, while these opportunities are advertised and shared among faculty and students, there is less support for students to independently identify them, have the confidence to pursue them, and generate competitive applications. I propose using a professional development approach to teach students how to find and apply for undergraduate summer research experiences. In this poster, I overview a module developed to introduce undergraduate students to the NSF Research Experience for Undergraduates (REU) program. I then use this module to establish a framework for a Faculty Mentoring Network (FMN). This network will support faculty wanting to adapt and create modules to teach professional development skills to apply to summer undergraduate research programs successfully. To narrow the scope of our FMN, we will focus on NSF REU programs.
title: Design/Simulation of microelectronics using VLSI design techniques
title: Σχεδίαση/Προσομοίωση μικροηλεκτρονικών κυκλωμάτων με τεχνικές VLSI
titleType: AlternativeTitle
Creators: name: Γιαννακούλης, Αλέξανδρος
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2021
Subjects: CMOS
VLSI
SRAM
Amplifiers
Logic gates
Integrated circuits
Binary counters
Analog CMOS components

description: In this paper, simple logic circuits were used to design more advanced, yet basic and essential MOS components. The 4-Stage Binary Counter can count sequentially 2^4 bits and is used in a variety of applications like program counting, random number generation and as a counter in general. It consists of a simple design, but is important to also be familiar with the basic components that are used in the making of the counter. In order for the reader to have a general idea, there are a lot of design choices and in this paper there are a few different designs of the same components. The random number generation process is very important especially in cryptography and in randomizing elements like in games. Random number generation can be achieved with software programs and with hardware devices. A hardware random number generation is a device that generates numbers from a physical process, in contrast to algorithmical. A true random number can be obtained only through hardware, because the microscopic phenomena used are, in theory, completely unpredictable. The program counter and instructions decoder are important components in addressing the programs and processes running in the memory, as well as which system in the integrated circuit needs the attention of the processor and for what period of time. These components work closely with memory and the processor. Memory is an essential component of every processor and advanced application. There are a lot of types of memories with their advantages and disadvantages depending on the application. This paper deals with Static Random Access Memory cell designs, which are easy to make and comprehensible, as well as generally good and reliable memory types. Additionally, memory needs some extra components in order to work properly, like a decoder to write reliably the new information into the memory cells and a multiplexer to read the information from the memory cells. However, CMOS circuits aren’t only digital, there are a lot of analog signals in a CMOS circuit which need constant conversion to digital as well as to analog and also some kind of comparison between them. Components like the differential amplifier are important in a variety of applications such as memory, for comparison of signals and also as amplifiers.
Sonnenfleckenzeichnung Nr. 24526.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 02.09.1974, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Las organizaciones políticas étnicas en Colombia. Los indígenas y las elecciones 1990-2006
Creators: name: Duque Daza, Javier
Publisher: name: Ibero-Amerikanisches Institut (Berlin)
Year: 2014
Subjects: Indígenas; Participación electoral; Cambio institucional; Colombia; Siglos XX-XXI; Indigenous; Electoral participation; Institutional change; 20th-21st Century

description: Después de una larga tradición organizativa y de un relativo aislamiento de los procesos electorales, durante las últimas dos décadas muchas organizaciones indígenas de América Latina han transitado de formas de organización y movilización social hacia formas de participación política más directas. El presente artículo analiza el caso colombiano durante el periodo 1990-2006. A partir de una perspectiva que aborda el surgimiento de organizaciones partidistas con base en variables sociales y políticas, enfatiza en la importancia del cambio institucional en la inserción de las comunidades indígenas colombianas en la competencia electoral. El artículo describe el proceso de conformación de las organizaciones comunitario-políticas indígenas, los factores internos y externos que han incidido en su surgimiento y consolidación, sus dinámicas competitivas y los resultados que han obtenido durante casi dos décadas de participación electoral.
Abstract
After a long organizational tradition and a relative isolation of the electoral processes, during the last two decades many organizations indigenous to Latin America have travelled of forms of organization and social mobilization towards more direct forms of political participation. The present article analyses the Colombian case during the period 1990-2006. From a perspective that approaches the emergence of partisan organizations with base in social and political variables, the article emphasizes the importance of the institutional change the insertion of the indigenous Colombian communities in the electoral competition. The article describes the process of conformation of the community-political indigenous organizations, the internal and external factors that have affected in your emergence and consolidation, your competitive dynamics and the results that they have obtained during almost two decades of electoral participation.
description: IBEROAMERICANA, Vol. 8, Núm. 32 (2008)
Sonnenfleckenzeichnung Nr. 24555.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 10.10.1974, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Актуализация возможностей проблемного обучения
Creators: name: Амриддинова Жасмина, Кудратова Гулрух Иззатуллаевна преподаватель кафедры русского языка и литературы Узбекско-финского Пeд.Института
name: Норимова Э'тибор, Кудратова Гулрух Иззатуллаевна преподаватель кафедры русского языка и литературы Узбекско-финского Пeд.Института
Publisher: name: Zenodo
Year: 2024

description: Эта статья посвящена проблемно-ориентированному обучению (PBL) - педагогическому подходу, который ставит учащихся в центр их учебного процесса. В нем рассматриваются преимущества PBL, приводится анализ литературы для понимания ее эффективности, излагаются методы внедрения, представлены результаты исследований, проводится обсуждение последствий и даются выводы и предложения по дальнейшему внедрению и совершенствованию.
Centroamérica: territorios de violencia. Presentación
Creators: name: Huhn, Sebastian
name: Oettler, Anika
name: Peetz, Peter
Publisher: name: Ibero-Amerikanisches Institut (Berlin)
Year: 2014
Subjects: Centroamérica; Violencia

description: Presentación al dossier
description: IBEROAMERICANA, Vol. 8, Núm. 32 (2008)
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 03.10.1974, erstellt von Georgeta Maris, Observatorium Bukarest
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage am Astronomischen Observatorium Bukarest, Solarsektor, Rumänien. Später wurden ergänzende Angaben aufgrund weiterer Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Instrument: Zeiss-Refraktor (Öffnung 130mm, f = 1950mm, projiziertes Sonnenbild D = 25cm)
Additional file 1 of Ecology and geography of Cache Valley virus assessed using ecological niche modeling
Creators: name: Muller, John A.
name: López, Krisangel
name: Escobar, Luis E.
name: Auguste, Albert J.
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1.
Pioneras de la modernidad: Grete Stern y Marie Langer en Argentina
Creators: name: Hopfengärtner, Johanna
Publisher: name: Ibero-Amerikanisches Institut (Berlin)
Year: 2014
Subjects: Grete Stern; Marie Langer; Fotografía; Psicoanálisis; Argentina; Alemania; Siglo XX

description: La historia de la fotografía moderna y la del psicoanálisis en Argentina están estrechamente vinculadas con los nombres de dos mujeres que se refugiaron en las orillas del Río de la Plata durante el tiempo del nacional-socialismo: Grete Stern (1904-1999) y Marie Langer (1910-1987). Ambas se encontraban en los comienzos de sus carreras cuando se vieron forzadas a abandonar sus países natales. Habían pasado los años decisivos de sus formaciones personales y profesionales en la época de la entreguerra, cuando las ciudades de Berlín y Viena constituían laboratorios de la modernidad, entornos estimulantes para el desarrollo de las artes, las ciencias y los estilos de vidas diferentes.
description: IBEROAMERICANA, Vol. 9, Núm. 33 (2009)
Sonnenfleckenzeichnung Nr. 24532.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 10.09.1974, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Cut Problems on Graphs
Creators: name: Nover, Alexander
Publisher: name: Universität Osnabrück
Year: 2022
Subjects: subject: maximum cut
subject: maximum bond
subject: minimum multicut
subject: discrete geometry
subject: combinatorial optimization
subject: 510 - Mathematik

description: Cut problems on graphs are a well-known and intensively studied class of optimization problems. In this thesis, we study the maximum cut problem, the maximum bond problem, and the minimum multicut problem through their associated polyhedra, i.e., the cut polytope, the bond polytope, and the multicut dominant, respectively. Continuing the research on the maximum cut problem and the cut polytope, we present a linear description for cut polytopes of K_{3,3}-minor-free graphs as well as an algorithm solving the maximum cut problem on these graphs in the same running time as planar maximum cut. Moreover, we give a complete characterization of simple and simplicial cut polytopes. Considering the maximum cut problem from an algorithmic point of view, we propose an FPT-algorithm for the maximum cut problem parameterized by the crossing number. We start the structural study of the bond polytope by investigating its basic properties and the effect of graph operations on the bond polytope and its facet-defining inequalities. After presenting a linear-time reduction of the maximum bond problem to the maximum bond problem on 3-connected graphs, we discuss valid and facet defining inequalities arising from edges and cycles. These inequalities yield a complete linear description for bond polytopes of 3-connected planar (K_5-e)-minor-free graphs. This polytopal result is mirrored algorithmically by proposing a linear-time algorithm for the maximum bond problem on (K_5-e)-minor-free graphs. Finally, we start the structural study of the multicut dominant. We investigate basic properties, which gives rise to lifting and projection results for the multicut dominant. Then, we study the effect of graph operations on the multicut dominant and its facet-defining inequalities. Moreover, we present facet-defining inequalities supported on stars, trees, and cycles as well as separation algorithms for the former two classes of inequalities.
Daniel Ortega now: el retorno de sí mismo
Creators: name: Rocha, José Luis
Publisher: name: Ibero-Amerikanisches Institut (Berlin)
Year: 2014
Subjects: Daniel Ortega; Política; Presidencia; Nicaragua; Siglo XXI

description: La historia política latinoamericana está salpicada de sorprendentes retornos al poder de mandatarios que dejaron profundas huellas en el devenir de los países que gobernaron con puño pétreo, manu militari o ágiles dedos cleptómanos: Getulio Vargas, Juan Domingo Perón y Alan Gabriel Ludwig García Pérez son sólo algunos, los más trompeteados. El primero demoró seis años entre su tercer y cuarto períodos y al segundo le tomó 18 años sentarse por tercera vez en la silla presidencial. Ninguno puso en escena un retorno de lo mismo. Ahora que después de 17 años Daniel Ortega se une a este grupo de variopinta moral, los aspectos más controversiales de su retorno son lo que tiene de lo mismo, lo que imita de lo mismo y lo que rompe con lo mismo. Segmentaré este somero balance de su gestión en esas tres dimensiones.
description: IBEROAMERICANA, Vol. 9, Núm. 33 (2009)
Sonnenfleckenzeichnung Nr. 24503.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 05.08.1974, erstellt von Johann Dürst
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Nicaragua: orteguismo y feminismo
Creators: name: Oettler, Anika
Publisher: name: Ibero-Amerikanisches Institut (Berlin)
Year: 2014
Subjects: Daniel Ortega; Política; Autoritarismo; Feminismo; Nicaragua; Siglo XXI

description: Cuando perdió el Frente Sandinista de Liberación Nacional (FSLN) en las elecciones de 1990, pocos se imaginaban que Daniel Ortega, comandante histórico de la guerrilla y presidente en los años ochenta, actuaría de una manera cínica y burlándose del pluralismo político al retornar a la presidencia casi dos décadas después. En los últimos dos años, no obstante, muchos de éstos fueron sorprendidos por la velocidad, la perseverancia y el descaro con los que la pareja presidencial, Daniel Ortega y Rosario Murillo, socavaba los fundamentos de la democracia nicaragüense. Los ejemplos siguientes demuestran que particularmente el movimiento feminista se halla bajo el fuego cruzado de las actividades de la pareja presidencial.
description: IBEROAMERICANA, Vol. 9, Núm. 33 (2009)
In silico analysis of phytochemicals as potential inhibitors of proteases involved in SARS-CoV-2 infection
Creators: name: Umadevi, Palaniyandi
name: Manivannan, Subramanian
name: Fayad, Abdulkabeer Muhammed
name: Shelvy, Sreekumar
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: 110309 Infectious Diseases
subject: 60506 Virology

description: In silico analysis of six phytochemicals, flabelliferin, marmelosin, piperine, ocimin, curcumin and leucoanthocyanin, along with three drug compounds, nelfinavir, remdesivir and hydroxychloroquine, as positive control against drug targets of one SARS-CoV-2 viral protease, COVID-19 main protease (SARS CoV-2 3CLpro/Mpro), two coronavirus proteases, SARS-CoV main peptidase (SARS CoV Mpro), SARS-CoV main proteinase (SARS CoV 3CLpro), and one human cellular transmembrane serine proteinase (TMPRSS2), was carried out. Except leucoanthocyanin all other phytochemicals proved better than all three positive control drugs against SARS-CoV main peptidase, whereas, flabelliferin was found to be the potential inhibitor for SARS-CoV main proteinase out performing all the positive control drugs and phytochemicals. Amongst the compounds studied, the best inhibitor for COVID-19 main protease was nelfinavir followed by flabelliferin and ocimin. Flabelliferin was found to the best promising inhibitor of human cellular transmembrane serine proteinase, followed by nelfinavir, curcumin, piperine and marmelosin. The result on the inhibition of human cellular transmembrane serine proteinase against COVID-19 has a stable therapeutic advantage as mutation may quickly occur on viral drug targets. Hence, all the phytochemicals tested in the present study are the potential inhibitors of the all the four drug targets and can form a part of therapeutics against COVID-19 with further clinical studies. Communicated by Ramaswamy H. Sarma
Additional file 1 of U-shaped association between triglyceride-glucose index and all-cause mortality among critically ill pediatrics: a population-based retrospective cohort study
Creators: name: Gao, Qi
name: Luo, Fan
name: Yu, Hongxue
name: Lin, Yuxin
name: Xu, Ruqi
name: Li, Pingping
name: Zhang, Yuping
name: Liu, Jiao
name: Su, Licong
name: Li, Yanqin
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Additional file1 (DOCX 29 kb)
¿De hacendado a revolucionario? Mel Zelaya y el giro hacia la izquierda del gobierno hondureño
Creators: name: Peetz, Peter
Publisher: name: Ibero-Amerikanisches Institut (Berlin)
Year: 2014
Subjects: Manuel Zelaya; Política; Izquierdas; Honduras; Siglo XXI

description: El 25 de agosto de 2008, el presidente de Honduras, Manuel “Mel” Zelaya, firmó para su país el convenio de adhesión a la iniciativa de integración regional propagada por Hugo Chávez, conocido bajo el nombre de ALBA (Alternativa Bolivariana para los Pueblos de Nuestra América). ¿Son las políticas de Mel Zelaya comparables con las de Chávez, Ortega y Morales? ¿Está el presidente de Honduras intentando seriamente implementar políticas que corresponden a alguna corriente ideológica de izquierda? Para un análisis que vaya más allá del nivel superficial de la retórica política y de los hechos placativos es preciso interpretar las políticas supuestamente izquierdistas de Zelaya considerando tanto la cultura política como la actual coyuntura política en Honduras.
description: IBEROAMERICANA, Vol. 9, Núm. 33 (2009)
Platorchestia undetermined
Creators: name: Pérez-Schultheiss, Jorge
name: Fernández, Leonardo D.
name: Ribeiro, Felipe Bezerra
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Amphipoda
Talitridae
Platorchestia
Platorchestia undetermined

description: Platorchestia sp.
(Fig. 7)
Material examined: 5 males, 1 female (MNHNCL AMP-16002): Antofagasta, Región de Antofagasta, -23.61336 -70.39204, 2022-08-22, coll. J. Pérez-Schultheiss, under stones, partially submerged in small stream, JP-556.
Remarks: The specimens belong to the Platorchestia platensis complex (sensu Kim et al. 2013), which was originally characterized by the presence of strong sexual dimorphism in the antennae and male pereopod 7 (cf. group 1 of Miyamoto & Morino 2004 or the restricted concept of Platorchestia of Myers & Lowry 2023). The material examined shows a combination of characters that does not match exactly with any described species, but the specimens are apparently more related to Platorchestia pacifica Miyamoto & Morino, 2004, P. platensis (Krøyer, 1845), P. paraplatensis Serejo & Lowry, 2008 and particularly P. oliveirae Myers & Lowry, 2023, with which it shares the cuspidactylate dactylus of gnathopod 1 (fig. 7GN1), the produced posterior lobe of the coxa 6 (fig. 7CX6), the wide carpus of pereopod 7 (fig. 7P7) and telson with two groups of dorsolateral setae (fig. 7T). It is also similar to Demaorchestia parapacifica (Kim, Jung & Min, 2013) in the general structure of gnathopod 2 and the appearance of the carpus of pereopod 7, which is widened, but not especially incrassate as in other species of the P. platensis complex. The genus Demaorchestia was recently described by Lowry & Myers (2022), for species originally assigned to P. platensis and other allied species with simplidactylate male gnathopod 1.
The reported morphological observations strongly suggest that we are dealing with a new species, but we refrain from describing it here because unpublished molecular evidence indicates that these specimens are related to material from Bermuda, identified as Platorchestia monodi by Wildish et al. (2016), material posteriorly synonymized under P. oliverae (Myers and Lowry 2023). The observed morphological patterns and the variation in some diagnostic morphological characters among specimens of Platorchestia and Demaorchestia species (see e.g. Morino 2023), suggests a complex taxonomic problem, which requires a complete integrative study.
Distribution: Hitherto the presence of Platorchestia in southeastern Pacific has been confirmed only for Antofagasta (Antofagasta Region) (Fig. 12A), in a small creek discharged over a mixed, rocky and sandy beach (Fig. 13A).
description: Published as part of Pérez-Schultheiss, Jorge, Fernández, Leonardo D. & Ribeiro, Felipe Bezerra, 2024, Two new genera of coastal Talitridae (Amphipoda: Senticaudata) from Chile, with the first record of Platorchestia Bousfield, 1982 in the southeastern Pacific coast, pp. 195-218 in Zootaxa 5477 (2) on page 205, DOI: 10.11646/zootaxa.5477.2.5, http://zenodo.org/record/12683442
Sonnenfleckenzeichnung Nr. 24505.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 07.08.1974, erstellt von Johann Dürst
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Searching for potential drugs against SARS-CoV-2 through virtual screening on several molecular targets
Creators: name: Almeida, Joyce S. F. D.
name: Botelho, Fernanda D.
name: de Souza, Felipe R.
name: dos Santos, Marcelo C.
name: da Silva Goncalves, Arlan
name: Rodrigues, Rodrigo L. B.
name: Cardozo, Monique
name: Kitagawa, Daniel A. S.
name: Vieira, Leandro A.
name: Silva, Raphael S. F.
name: Cavalcante, Samir F. A.
name: da C. Bastos, Leonardo
name: de O. T. Nogueira, Mariana
name: de Santana, Priscila I. R.
name: de O. C. Brum, Juliana
name: Nepovimova, Eugenie
name: Kuca, Kamil
name: LaPlante, Steven R.
name: Galante, Erick B. F.
name: Franca, Tanos C. C.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: The acute respiratory syndrome caused by the SARS-CoV-2, known as COVID-19, has been ruthlessly tormenting the world population for more than six months. However, so far no effective drug or vaccine against this plague have emerged yet, despite the huge effort in course by researchers and pharmaceutical companies worldwide. Willing to contribute with this fight to defeat COVID-19, we performed a virtual screening study on a library containing Food and Drug Administration (FDA) approved drugs, in a search for molecules capable of hitting three main molecular targets of SARS-CoV-2 currently available in the Protein Data Bank (PDB). Our results were refined with further molecular dynamics (MD) simulations and MM-PBSA calculations and pointed to 7 multi-target hits which we propose here for experimental evaluation and repurposing as potential drugs against COVID-19. Additional rounds of docking, MD simulations and MM-PBSA calculations with remdesivir suggested that this compound can also work as a multi-target drug against SARS-CoV-2. Communicated by Ramaswamy H. Sarma
Sonnenfleckenzeichnung Nr. 24572.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 18.11.1974, erstellt von Antoine Zelenka
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Single center experiences with telemetric intracranial pressure measurements in patients with CSF circulation disturbances
Creators: name: Pennacchietti, Valentina
name: Prinz, Vincent
name: Schaumann, Andreas
name: Finger, Tobias
name: Schulz, Matthias
name: Thomale, Ulrich W.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2020
Subjects: subject: Hydrocephalus
subject: Intracranial pressure
subject: Telemetric
subject: Sensor Reservoir
subject: Neurovent-P-tel
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Hydrocephalus may present with heterogeneous signs and symptoms. The indication for its treatment and the optimal drainage in complex cases may be challenging. Telemetric intracranial pressure measurements (TICPM) may open new perspectives for those circumstances. We report our experiences using the Neurovent-P-tel and the Sensor Reservoir in a retrospective study. Methods: A series of 21 patients (age range 10–39.5 years) treated in our Pediatric Neurosurgical Unit receiving a TICPM was analyzed. In 8 patients, a Neurovent-P-Tel was implanted; 13 patients received a Sensor Reservoir, 6 of which as a stand-alone implant, while 7 were already shunted. TICPM were performed on an outpatient basis. Possible complications, follow-up surgeries, and TICPM were analyzed. Results: Concerning the complications, one infection was seen in each group and one postoperative seizure was observed in the P-tel group. TICPM-assisted shunt adjustments lead to clinical improvements in six patients in the P-tel group and six patients in the Sensor Reservoir group. In four out of six non-shunted patients, TICPM contributed to the indication toward shunt implantation. Conclusions: TICPM seems to be a promising tool to improve clinical management of shunted patients with complex hydrocephalus. The two available systems will need further technical improvements, concerning implantation time, measurements, and data analysis in order to optimize handling and interpretation of the data.
Sonnenfleckenzeichnung Nr. 24476.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 02.07.1974, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1974

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
JALLA 2008, Santiago de Chile
Creators: name: Nitschack, Horst
Publisher: name: Ibero-Amerikanisches Institut (Berlin)
Year: 2014
Subjects: Jornadas Andinas de Literatura Latinoamericana; Chile; Siglo XXI

description: Crónica de las octavas “Jornadas Andinas de Literatura Latinoamericana” que se realizaron entre el 11 y el 15 de agosto de 2008 y que fueron organizadas por el Centro de Estudios Culturales Latinoamericanos de la Universidad de Chile con la colaboración de las universidades Pontificia Universidad Católica de Chile, Universidad Santiago de Chile y Universidad Alberto Hurtado.
description: IBEROAMERICANA, Vol. 9, Núm. 33 (2009)
Synthesis of carbazole based α-aminophosphonate derivatives: design, molecular docking and in vitro cholinesterase activity
Creators: name: Shaikh, Sarfaraz
name: Dhavan, Pratik
name: Singh, Pinky
name: Uparkar, Jasmin
name: Vaidya, S. P.
name: Jadhav, B. L.
name: Ramana, M. V.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: 60506 Virology

description: A series of novel carbazole based α-aminophosphonate derivatives were synthesized under solvent-free condition, characterized and evaluated for their cholinesterase inhibition, enzyme kinetic inhibition, in-vitro cell viability using N2a cells, neuroprotective studies against H2O2-induced stress using N2a cells and antioxidant studies using DPPH radical activity. Test compounds displayed better AChE activity (0.475 to 7.781 µM) than BuChE (3.306 to 21.32 µM). Compound 4j was most potent derivative against AChE as well as BuChE with IC50=0.475 ± 0.12 µM and IC50=3.306 ± 0.21 µM respectively. Kinetic inhibition studies indicate that compound 4j exhibits mixed type inhibition against both enzymes which was supported by molecular docking studies. Cell viability studies showed that compounds did not induce any cytotoxic effect against N2a cells using MTT assay. Also, compound 4j, 4 s and 4r were subjected to H2O2-induced stress using N2a cells and were found to be protective in nature. ADME predictions were carried out to understand the pharmacokinetics behaviour. Communicated by Ramaswamy H. Sarma