cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: 01_0481
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Ligusticum scothicum Linnaeus 1753
Creators: name: Jarvis, Charlie
Publisher: name: Linnaean Society of London in association with the Natural History Museum
Year: 2007
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Apiales
Apiaceae
Ligusticum
Ligusticum scothicum

description: Ligusticum scothicum Linnaeus, Species Plantarum 1: 250. 1753.
"Habitat ad litora Maris in Anglia, Suecia." RCN: 2010.
 Lectotype (Reduron & Jarvis in Jarvis & al., Regnum Veg. 127: 61. 1993): Herb. Clifford: 97, Ligusticum 3 (BM-000558302).
 Generitype of Ligusticum Linnaeus (vide Hitchcock, Prop. Brit. Bot.: 140. 1929).
 Current name: Ligusticum scothicum L. (Apiaceae).
 Note: Specific epithet spelled “scothieum” in the protologue.
description: Published as part of Jarvis, Charlie, 2007, Chapter 7: Linnaean Plant Names and their Types (part L), pp. 610-650 in Order out of Chaos. Linnaean Plant Types and their Types, London :Linnaean Society of London in association with the Natural History Museum on page 632, DOI: 10.5281/zenodo.291971
Site mutations disrupt inter-helical H-bonds (alpha14W-alpha67T and beta15W-beta72S) involved in kinetic steps in the hemoglobin R-->T transition without altering the free energies of oxygenation.
Creators: name: Ching-Hsuan  Tsai
name: Simplaceanu, Virgil
name: Ho, Nancy T.
name: Tong-Jian  Shen
name: Daojing  Wang
name: Spiro, Thomas G.
name: Ho, Chien
Publisher: name: Carnegie Mellon University
Year: 2003
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Three recombinant mutant hemoglobins (rHbs) of human normal adult hemoglobin (Hb A), rHb (alphaT67V), rHb (betaS72A), and rHb (alphaT67V, betaS72A), have been constructed to test the role of the tertiary intra-subunit H-bonds between alpha67T and alpha14W and between beta72S and beta15W in the cooperative oxygenation of Hb A. Oxygen-binding studies in 0.1 M sodium phosphate buffer at 29 degrees C show that rHb (alphaT67V), rHb (betaS72A), and rHb (alphaT67V, betaS72A) exhibit oxygen-binding properties similar to those of Hb A. The binding of oxygen to these rHbs is highly cooperative, with a Hill coefficient of approximately 2.8, compared to approximately 3.1 for Hb A. Proton nuclear magnetic resonance (NMR) studies show that rHb (alphaT67V), rHb (betaS72A), rHb (alphaT67V, betaS72A), and Hb A have similar quaternary structures in the alpha(1)beta(2) subunit interfaces. In particular, the inter-subunit H-bonds between alpha42Tyr and beta99Asp and between beta37Trp and alpha94Asp are maintained in the mutants in the deoxy form. There are slight perturbations in the distal heme pocket region of the alpha- and beta-chains in the mutants. A comparison of the exchangeable 1H resonances of Hb A with those of these three rHbs suggests that alpha67T and beta72S are H-bonded to alpha14W and beta15W, respectively, in the CO and deoxy forms of Hb A. The absence of significant free energy changes for the oxygenation process of these three rHbs compared to those of Hb A, even though the inter-helical H-bonds are abolished, indicates that these two sets of H-bonds are of comparable strength in the ligated and unligated forms of Hb A. Thus, the mutations at alphaT67V and betaS72A do not affect the overall energetics of the oxygenation process. The preserved cooperativity in the binding of oxygen to these three mutants also implies that there are multiple interactions involved in the oxygenation process of Hb A.
Generalized Brown representability in homotopy categories
Creators: name: Rosicky, J.
Publisher: name: arXiv
Year: 2005
Subjects: subject: Category Theory (math.CT)
subject: FOS: Mathematics
subject: 18G55

description: We show that the homotopy category of a combinatorial stable model category $\ck$ is well generated. It means that each object $K$ of $\Ho(\ck)$ is an iterated weak colimit of $λ$-compact objects for some cardinal $λ$. A natural question is whether each $K$ is a weak colimit of $λ$-compact objects. We show that this is related to (generalized) Brown representability of $\Ho(\mathcal K)$.
description: This is the correction of the original submission which was published in Theory Appl. Categ. 14 (2005), 451-479. Propositions 4.2 and 4.3 from the original submission are not correct. Thus the claims of Theorems 5.4, 5.7 and their Corollaries 5.8, 5.9 and 5.10 remain open. I am grateful to J. F. Jardine and F. Muro for pointing it out
Non-perturbative Kahler Potential, Dilaton Stabilization and Fayet-Iliopoulos Term
Creators: name: Higaki, Tetsutaro
name: Kawamura, Yoshiharu
name: Kobayashi, Tatsuo
name: Nakano, Hiroaki
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the dilaton stabilization in models with anomalous U(1) symmetry by adding specific string-motivated, non-perturbative corrections to the tree-level dilaton Kähler potential. We find that the non-perturbative effects can stabilize the dilaton at a desirably large value. We also observe that the size of Fayet-Iliopoulos term is reduced at the stabilized point.
description: 10 pages, 2 figures
The descendants of the first quasars in the BlueTides simulation
Creators: name: Tenneti, Ananth
name: Di Matteo, Tiziana
name: Croft, Rupert
name: Garcia, ThomasJae
name: Feng, Yu
Publisher: name: arXiv
Year: 2017
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Supermassive blackholes with masses of a billion solar masses or more are known to exist up to $z=7$. However, the present-day environments of the descendants of first quasars is not well understood and it is not known if they live in massive galaxy clusters or more isolated galaxies at $z=0$. We use a dark matter-only realization (BTMassTracer) of the BlueTides cosmological hydrodynamic simulation to study the halo properties of the descendants of the most massive black holes at $z=8$. We find that the descendants of the quasars with most massive black holes are not amongst the most massive halos. They reside in halos of with group-like ($\sim 10^{14}M_{\odot}$) masses, while the most massive halos in the simulations are rich clusters with masses $\sim 10^{15} M_{\odot}$. The distribution of halo masses at low redshift is similar to that of the descendants of least massive black holes, for a similar range of halo masses at $z=8$, which indicates that they are likely to exist in similar environments. By tracing back to the $z = 8$ progenitors of the most massive (cluster sized) halos at $z=0$; we find that their most likely black hole mass is less than $10^7 M_{\odot}$; they are clearly not amongst the most massive black holes. We also provide estimates for the likelihood of finding a high redshift quasar hosting a black hole with masses above $10^{7} M_{\odot}$ for a given halo mass at $z=0$. For halos above $10^{15} M_{\odot}$, there is only $20 \%$ probability that their $z=8$ progenitors hosted a black hole with mass above $10^{7} M_{\odot}$.
description: 7 pages, 7 figures, submitted to MNRAS
Additional file 7 of Sustained glymphatic transport and impaired drainage to the nasal cavity observed in multiciliated cell ciliopathies with hydrocephalus
Creators: name: Xue, Yuechuan
name: Gursky, Zachary
name: Monte, Brittany
name: Koundal, Sunil
name: Liu, Xiaodan
name: Lee, Hedok
name: Michurina, Tatyana V.
name: Mellanson, Kennelia A.
name: Zhao, Lucy
name: Nemajerova, Alice
name: Kahle, Kristopher T.
name: Takemaru, Ken-Ichi
name: Enikolopov, Grigori
name: Peunova, Natalia I.
name: Benveniste, Helene
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health
subject: Hematology

description: Additional file 7: Figure S5. AQP4 expression is unchanged in the vasculature of FOXJ1-Cre;CEP164fl/fl mice.
Single-Cell Genetic Analysis Reveals Insights into Clonal Development of Prostate Cancers and Indicates Loss of PTEN as a Marker of Poor Prognosis.
Creators: name: Heselmeyer-Haddad, Kerstin M.
name: Garcia, Lissa Y. Berroa
name: Bradley, Amanda
name: Leanora  Hernandez
name: Hu, Yue
name: Habermann, Jens K.
name: Dumke, Christoph
name: Thorns, Christoph
name: Perner, Sven
name: Pestova, Ekaterina
name: Burke, Catherine
name: Chowdhury, Salim A.
name: Schwartz, Russell
name: Schäffer, Alejandro H.
name: Paris, Pamela L.
name: Ried, Thomas
Publisher: name: Carnegie Mellon University
Year: 2014
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Gauging the risk of developing progressive disease is a major challenge in prostate cancer patient management. We used genetic markers to understand genomic alteration dynamics during disease progression. By using a novel, advanced, multicolor fluorescence in situ hybridization approach, we enumerated copy numbers of six genes previously identified by array comparative genomic hybridization to be involved in aggressive prostate cancer [TBL1XR1, CTTNBP2, MYC (alias c-myc), PTEN, MEN1, and PDGFB] in six nonrecurrent and seven recurrent radical prostatectomy cases. An ERG break-apart probe to detect TMPRSS2-ERG fusions was included. Subsequent hybridization of probe panels and cell relocation resulted in signal counts for all probes in each individual cell analyzed. Differences in the degree of chromosomal and genomic instability (ie, tumor heterogeneity) or the percentage of cells with TMPRSS2-ERG fusion between samples with or without progression were not observed. Tumors from patients that progressed had more chromosomal gains and losses, and showed a higher degree of selection for a predominant clonal pattern. PTEN loss was the most frequent aberration in progressers (57%), followed by TBL1XR1 gain (29%). MYC gain was observed in one progresser, which was the only lesion with an ERG gain, but no TMPRSS2-ERG fusion. According to our results, a probe set consisting of PTEN, MYC, and TBL1XR1 would detect progressers with 86% sensitivity and 100% specificity. This will be evaluated further in larger studies.
Additional file 1 of Impaired long-range excitatory time scale predicts abnormal neural oscillations and cognitive deficits in Alzheimer’s disease
Creators: name: Verma, Parul
name: Ranasinghe, Kamalini
name: Prasad, Janani
name: Cai, Chang
name: Xie, Xihe
name: Lerner, Hannah
name: Mizuiri, Danielle
name: Miller, Bruce
name: Rankin, Katherine
name: Vossel, Keith
name: Cheung, Steven W.
name: Nagarajan, Srikantan S.
name: Raj, Ashish
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Cell Biology
Neuroscience
Mental Health

description: Additional file 1. Please see the supplementary PDF for the model equations and supplementary figures.
Charmed Baryon Weak Decays with SU(3) Flavor Symmetry
Creators: name: Geng, C. Q.
name: Hsiao, Y. K.
name: Liu, Chia-Wei
name: Tsai, Tien-Hsueh
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We study the semileptonic and non-leptonic charmed baryon decays with $SU(3)$ flavor symmetry, where the charmed baryons can be ${\bf B}_{c}=(Ξ_c^0,Ξ_c^+,Λ_c^+)$, ${\bf B}'_{c}=(Σ_c^{(++,+,0)},Ξ_{c}^{\prime(+,0)},Ω_c^0)$, ${\bf B}_{cc}=(Ξ_{cc}^{++},Ξ_{cc}^+,Ω_{cc}^+)$, or ${\bf B}_{ccc}=Ω^{++}_{ccc}$. With ${\bf B}_n^{(\prime)}$ denoted as the baryon octet (decuplet), we find that the ${\bf B}_{c}\to {\bf B}'_n\ell^+ν_\ell$ decays are forbidden, while the $Ω_c^0\to Ω^-\ell^+ν_\ell$, $Ω_{cc}^+\toΩ_c^0\ell^+ν_\ell$, and $Ω_{ccc}^{++}\to Ω_{cc}^+\ell^+ν_\ell$ decays are the only existing Cabibbo-allowed modes for ${\bf B}'_{c}\to {\bf B}'_n\ell^+ν_\ell$, ${\bf B}_{cc}\to {\bf B}'_c\ell^+ν_\ell$, and ${\bf B}_{ccc}\to {\bf B}_{cc}^{(\prime)}\ell^+ν_\ell$, respectively. We predict the rarely studied ${\bf B}_{c}\to {\bf B}_n^{(\prime)}M$ decays, such as ${\cal B}(Ξ_c^0\toΛ^0\bar K^0,\,Ξ_c^+\toΞ^0π^+)=(8.3\pm 0.9,8.0\pm 4.1)\times 10^{-3}$ and ${\cal B}(Λ_c^+\to Δ^{++}π^-,\,Ξ_c^0\toΩ^- K^+)=(5.5\pm 1.3,4.8\pm 0.5)\times 10^{-3}$. For the observation, the doubly and triply charmed baryon decays of $Ω_{cc}^{+}\to Ξ_c^+\bar K^0$, $Ξ_{cc}^{++}\to (Ξ_c^+π^+$, $Σ_c^{++}\bar K^0)$, and $Ω_{ccc}^{++}\to (Ξ_{cc}^{++}\bar K^0,Ω_{cc}^+π^+,Ξ_c^+ D^+)$ are the favored Cabibbo-allowed decays, which are accessible to the BESIII and LHCb experiments.
description: 29 pages, no figure, a typo in the table corrected
Infrared Emission from Interstellar Dust. IV. The Silicate-Graphite-PAH Model in the Post-Spitzer Era
Creators: name: Draine, B. T.
name: Li, Aigen
Publisher: name: arXiv
Year: 2006
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Infrared (IR) emission spectra are calculated for dust composed of mixtures of amorphous silicate and graphitic grains, including varying amounts of polycyclic aromatic hydrocarbon (PAH) particles. The models are constrained to reproduce the average Milky Way extinction curve. The calculations include the effects of single-photon heating. Updated IR absorption properties for the PAHs are presented, that are consistent with observed emission spectra, including those newly obtained by Spitzer Space Telescope. We find a size distribution for the PAHs that results in emission band ratios consistent with observed spectra of the Milky Way and other galaxies. Emission spectra are presented for various intensities of the illuminating starlight. We calculate how the efficiency of emission into different IR bands depends on PAH size; the strong 7.7um emission feature is produced mainly by PAH particles containing <1000 C atoms. We show how the emission spectrum depends on U, the starlight intensity relative to the local interstellar radiation field. The submm and far-infrared emission is compared to the observed emission from the local interstellar medium. Using a simple distribution function, we calculate the emission spectrum for dust heated by a distribution of starlight intensities, such as occurs within galaxies. The models are parameterized by the PAH mass fraction qpah, the lower cutoff Umin, and the fraction gamma of the dust heated by starlight with U>Umin. We present graphical procedures using IRAC and MIPS photometry to estimate qpah, Umin, and gamma, the fraction f_PDR of the dust luminosity coming from photodissociation regions with U>100, and the total dust mass Mdust.
description: revised, to appear in ApJ. 57 pages. Revised version has numerous corrections, small changes to spectra, and includes model emissivities for photometric bands of Akari (IRC, FIS) and Herschel (PACS, SPIRE)
A note on multiple Dirichlet's q-L--function
Creators: name: Kim, Taekyun
Publisher: name: arXiv
Year: 2005
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11S80, 11B68, 11M99

description: Recently, the two variable $q$-$L$-functions which interpolate the generalized $q$-Bernoulli polynomials associated with $χ$ are introduced and studied, cf. [2]. In this paper, we construct multiple Dirichlet's $q$-$L$-function which interpolates the generalized multiple $q$-Bernoulli numbers attached to $χ$ at negative integer and study its properties.
description: 5 pages
Single-cell genetic analysis of ductal carcinoma in situ and invasive breast cancer reveals enormous tumor heterogeneity yet conserved genomic imbalances and gain of MYC during progression.
Creators: name: Heselmeyer-Haddad, Kerstin M.
name: Garcia, Lissa Y. Berroa
name: Bradley, Amanda
name: Clarymar  Ortiz-Melendez
name: Woei-Jyh  Lee
name: Christensen, Rebecca
name: Prindiville, Sheila A.
name: Calzone, Kathleen A.
name: Soballe, Peter W.
name: Chowdhury, Salim A.
name: Schwartz, Russell
name: Schäffer, Alejandro H.
name: Ried, Thomas
Publisher: name: Carnegie Mellon University
Year: 2012
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Ductal carcinoma in situ (DCIS) is a precursor lesion of invasive ductal carcinoma (IDC) of the breast. To understand the dynamics of genomic alterations in this progression, we used four multicolor fluorescence in situ hybridization probe panels consisting of the oncogenes COX2, MYC, HER2, CCND1, and ZNF217 and the tumor suppressor genes DBC2, CDH1, and TP53 to visualize copy number changes in 13 cases of synchronous DCIS and IDC based on single-cell analyses. The DCIS had a lower degree of chromosomal instability than the IDC. Despite enormous intercellular heterogeneity in DCIS and IDC, we observed signal patterns consistent with a nonrandom distribution of genomic imbalances. CDH1 was most commonly lost, and gain of MYC emerged during progression from DCIS to IDC. Four of 13 DCISs showed identical clonal imbalances in the IDCs. Six cases revealed a switch, and in four of those, the IDC had acquired a gain of MYC. In one case, the major clone in the IDC was one of several clones in the DCIS, and in another case, the major clone in the DCIS became one of the two major clones in the IDC. Despite considerable chromosomal instability, in most cases the evolution from DCIS to IDC is determined by recurrent patterns of genomic imbalances, consistent with a biological continuum.
Student Success Prediction in MOOCs
Creators: name: Gardner, Josh
name: Brooks, Christopher
Publisher: name: arXiv
Year: 2017
Subjects: subject: Computers and Society (cs.CY)
subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: Predictive models of student success in Massive Open Online Courses (MOOCs) are a critical component of effective content personalization and adaptive interventions. In this article we review the state of the art in predictive models of student success in MOOCs and present a categorization of MOOC research according to the predictors (features), prediction (outcomes), and underlying theoretical model. We critically survey work across each category, providing data on the raw data source, feature engineering, statistical model, evaluation method, prediction architecture, and other aspects of these experiments. Such a review is particularly useful given the rapid expansion of predictive modeling research in MOOCs since the emergence of major MOOC platforms in 2012. This survey reveals several key methodological gaps, which include extensive filtering of experimental subpopulations, ineffective student model evaluation, and the use of experimental data which would be unavailable for real-world student success prediction and intervention, which is the ultimate goal of such models. Finally, we highlight opportunities for future research, which include temporal modeling, research bridging predictive and explanatory student models, work which contributes to learning theory, and evaluating long-term learner success in MOOCs.
Simulation study of the contribution of oligomer/oligomer binding to capsid assembly kinetics.
Creators: name: Tiequan  Zhang
name: Schwartz, Russell
Publisher: name: Carnegie Mellon University
Year: 2006
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: The process by which hundreds of identical capsid proteins self-assemble into icosahedral structures is complex and poorly understood. Establishing constraints on the assembly pathways is crucial to building reliable theoretical models. For example, it is currently an open question to what degree overall assembly kinetics are dominated by one or a few most efficient pathways versus the enormous number theoretically possible. The importance of this question, however, is often overlooked due to the difficulties of addressing it in either theoretical or experimental practice. We apply a computer model based on a discrete-event simulation method to evaluate the contributions of nondominant pathways to overall assembly kinetics. This is accomplished by comparing two possible assembly models: one allowing growth to proceed only by the accretion of individual assembly subunits and the other allowing the binding of sterically compatible assembly intermediates any sizes. Simulations show that the two models perform almost identically under low binding rate conditions, where growth is strongly nucleation-limited, but sharply diverge under conditions of higher association rates or coat protein concentrations. The results suggest the importance of identifying the actual binding pattern if one is to build reliable models of capsid assembly or other complex self-assembly processes.
Simulated de novo assembly of golgi compartments by selective cargo capture during vesicle budding and targeted vesicle fusion.
Creators: name: Haijun  Gong
name: Debrup  Sengupta
name: Linstedt, Adam
name: Schwartz, Russell
Publisher: name: Carnegie Mellon University
Year: 2008
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: The Golgi apparatus is comprised of stacked cisternal membranes forming subcompartments specialized for posttranslational processing of newly synthesized secretory cargo. Recent experimental evidence indicates that the Golgi apparatus can undergo de novo biogenesis from the endoplasmic reticulum, but the mechanism by which the membranes self assemble into compartmentalized structures remains unknown. We developed a discrete-event computer simulation model to test whether two fundamental mechanisms-vesicle-coat-mediated selective concentration of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins during vesicle formation, and SNARE-mediated selective fusion of vesicles-suffice to generate and maintain compartments. Simulations verified that this minimal model is adequate for homeostasis of preestablished compartments, even in response to small perturbations, and for de novo formation of stable compartments. The model led to a novel prediction that Golgi size is in part dependent on target SNARE expression level. This prediction was supported by a demonstration that exogenous expression of the Golgi target SNARE syntaxin-5 alters Golgi size in living cells.
Similar properties of transient, persistent, and resurgent Na currents in GABAergic and non-GABAergic vestibular nucleus neurons.
Creators: name: Aryn Gittis
name: Lac, Sascha Du
Publisher: name: Carnegie Mellon University
Year: 2008
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Sodium currents in fast firing neurons are tuned to support sustained firing rates >50-60 Hz. This is typically accomplished with fast channel kinetics and the ability to minimize the accumulation of Na channels into inactivated states. Neurons in the medial vestibular nuclei (MVN) can fire at exceptionally high rates, but their Na currents have never been characterized. In this study, Na current kinetics and voltage-dependent properties were compared in two classes of MVN neurons with distinct firing properties. Non-GABAergic neurons (fluorescently labeled in YFP-16 transgenic mice) have action potentials with faster rise and fall kinetics and sustain higher firing rates than GABAergic neurons (fluorescently labeled in GIN transgenic mice). A previous study showed that these neurons express a differential balance of K currents. To determine whether the Na currents in these two populations were different, their kinetics and voltage-dependent properties were measured in acutely dissociated neurons from 24- to 40-day-old mice. All neurons expressed persistent Na currents and large transient Na currents with resurgent kinetics tuned for fast firing. No differences were found between the Na currents expressed in GABAergic and non-GABAergic MVN neurons, suggesting that differences in properties of these neurons are tuned by their K currents.
Short planar gradient coils for MR microscopy using concentric return paths.
Creators: name: Dodd, Stephen J.
name: Ho, Chien
Publisher: name: Carnegie Mellon University
Year: 2002
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: The aim of this work is to design a set of gradient coils with an optimal geometry for magnetic resonance microscopy studies. Designs for a three-axis gradient coil system particularly suited for studies with small radiofrequency coils are presented. The novel geometry involves a planar section with concentric return paths to keep the coil short. Reduction of the external field has been attempted by varying the positions of the return paths using a simulated annealing algorithm. A biplanar version of x- and z-directed prototype gradients was built and tested. A 2D-MR image of a grid phantom has been obtained on a 7-T MR instrument to demonstrate the theory. A three-axis set used as a surface gradient set has also been built and used to obtain high-resolution MR images.
Softening the Supersymmetric Flavor Problem in Orbifold GUTs
Creators: name: Kajiyama, Yuji
name: Kubo, Jisuke
name: Terao, Haruhiko
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The infra-red attractive force of the bulk gauge interactions is applied to soften the supersymmetric flavor problem in the orbifold SU(5) GUT of Kawamura. Then this force aligns in the infra-red regime the soft supersymmetry breaking terms out of their anarchical disorder at a fundamental scale, in such a way that flavor-changing neutral currents as well as dangerous CP-violating phases are suppressed at low energies. It is found that this dynamical alignment is sufficiently good compared with the current experimental bounds, as long as the diagonalization matrices of the Yukawa couplings are CKM-like.
description: 15 pages,4 figures
Additional file 8 of Sustained glymphatic transport and impaired drainage to the nasal cavity observed in multiciliated cell ciliopathies with hydrocephalus
Creators: name: Xue, Yuechuan
name: Gursky, Zachary
name: Monte, Brittany
name: Koundal, Sunil
name: Liu, Xiaodan
name: Lee, Hedok
name: Michurina, Tatyana V.
name: Mellanson, Kennelia A.
name: Zhao, Lucy
name: Nemajerova, Alice
name: Kahle, Kristopher T.
name: Takemaru, Ken-Ichi
name: Enikolopov, Grigori
name: Peunova, Natalia I.
name: Benveniste, Helene
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health
subject: Hematology

description: Additional file 8: Figure S6. AQP4 expression is increased around capillaries of p73−/− mice.
Impacts of Radial Mixing on the Galactic Thick and Thin Disks
Creators: name: Kawata, Daisuke
Publisher: name: arXiv
Year: 2017
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Using N-body simulations of the Galactic disks, we qualitatively study how the metallicity distributions of the thick and thin disk stars are modified by radial mixing induced by the bar and spiral arms. We show that radial mixing drives a positive vertical metallicity gradient in the mono-age disk population whose initial scale-height is constant and initial radial metallicity gradient is tight and negative. On the other hand, if the initial disk is flaring, with scale-height increasing with galactocentric radius, radial mixing leads to a negative vertical metallicity gradient, which is consistent with the current observed trend. We also discuss impacts of radial mixing on the metallicity distribution of the thick disk stars. By matching the metallicity distribution of N-body models to the SDSS/APOGEE data, we argue that the progenitor of the Milky Way's thick disk should not have a steep negative metallicity gradient.
description: 4 pages, 1 figure, to appear in the proceedings of the IAU Symposium 334 "Rediscovering our Galaxy", Potsdam, 10-14 July 2017, eds. C. Chiappini, I. Minchev, E. Starkenburg, M. Valentini
title: ADCO, Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.3 (2e moitié XIIIe siècle), Cart. 168 (11 H 66), f. 0031r
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2010
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.3 (2e moitié XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 168 (11 H 66), f. 0031r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.3 (2e moitié XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 168 (11 H 66), f. 0031r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Consequentialist conditional cooperation in social dilemmas with imperfect information
Creators: name: Peysakhovich, Alexander
name: Lerer, Adam
Publisher: name: arXiv
Year: 2017
Subjects: subject: Artificial Intelligence (cs.AI)
subject: Computer Science and Game Theory (cs.GT)
subject: Multiagent Systems (cs.MA)
subject: FOS: Computer and information sciences

description: Social dilemmas, where mutual cooperation can lead to high payoffs but participants face incentives to cheat, are ubiquitous in multi-agent interaction. We wish to construct agents that cooperate with pure cooperators, avoid exploitation by pure defectors, and incentivize cooperation from the rest. However, often the actions taken by a partner are (partially) unobserved or the consequences of individual actions are hard to predict. We show that in a large class of games good strategies can be constructed by conditioning one's behavior solely on outcomes (ie. one's past rewards). We call this consequentialist conditional cooperation. We show how to construct such strategies using deep reinforcement learning techniques and demonstrate, both analytically and experimentally, that they are effective in social dilemmas beyond simple matrix games. We also show the limitations of relying purely on consequences and discuss the need for understanding both the consequences of and the intentions behind an action.
The Intrinsic Size of Sagittarius A* from 0.35 cm to 6 cm
Creators: name: Bower, Geoffrey C.
name: Goss, W. M.
name: Falcke, Heino
name: Backer, Donald C.
name: Lithwick, Yoram
Publisher: name: arXiv
Year: 2006
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present new high-resolution observations of Sagittarius A* at wavelengths of 17.4 to 23.8 cm with the Very Large Array in A configuration with the Pie Town Very Long Baseline Array antenna. We use the measured sizes to calibrate the interstellar scattering law and find that the major axis size of the scattering law is smaller by ~6% than previous estimates. Using the new scattering law, we are able to determine the intrinsic size of Sgr A* at wavelengths from 0.35 cm to 6 cm using existing results from the VLBA. The new law increases the intrinsic size at 0.7 cm by ~20% and <5% at 0.35 cm. The intrinsic size is 13^{+7}_{-3} Schwarzschild radii at 0.35 cm and is proportional to lambda^gamma, where gamma is in the range 1.3 to 1.7.
description: ApJL, in press
Shiga toxin-binding site for host cell receptor GPP130 reveals unexpected divergence in toxin-trafficking mechanisms.
Creators: name: Somshuvra  Mukhopadhyay
name: Redler, Brendan
name: Linstedt, Adam
Publisher: name: Carnegie Mellon University
Year: 2013
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Shiga toxicosis is caused by retrograde trafficking of one of three types of Shiga toxin (STx), STx, STx1, or STx2. Trafficking depends on the toxin B subunits, which for STx and STx1 are identical and bind GPP130, a manganese (Mn)-sensitive intracellular trafficking receptor. Elevated Mn down-regulates GPP130, rendering STx/STx1 harmless. Its effectiveness against STx2, however, which is a serious concern in the developed world, is not known. Here we show that Mn-induced GPP130 down-regulation fails to block STx2 trafficking. To shed light on this result, we tested the purified B subunit of STx2 for binding to GPP130 and found that it failed to interact. We then mapped residues at the interface of the GPP130-STx/STx1 complex. In GPP130, binding mapped to a seven-residue stretch in its lumenal stem domain next to the transmembrane domain. This stretch was required for STx/STx1 transport. In STx/STx1, binding mapped to a histidine-asparagine pair on a surface-exposed loop of the toxin B subunit. Significantly, these residues are not conserved in STx2, explaining the lack of effectiveness of Mn against STx2. Together our results imply that STx2 uses an evolutionarily distinct trafficking mechanism and that Mn as a potential therapy should be focused on STx/STx1 outbreaks, which account for the vast majority of cases worldwide.
Additional file 1 of The impact of COVID-19 continuous containment and mitigation strategy on the epidemic of vector-borne diseases in China
Creators: name: Guo, Xiangyu
name: Ma, Chenjin
name: Wang, Lan
name: Zhao, Na
name: Liu, Shelan
name: Xu, Wangli
Publisher: name: figshare
Year: 2022
Subjects: Medicine
Neuroscience
Biological Sciences not elsewhere classified
Cancer
Science Policy
Computational Biology

description: Additional file 1: Table S1. Dates of provinces implementing response to public health emergency. Table S2. List of five vector-borne diseases, insect vectors, and pathogens. Table S3. Changes in the average yearly incidence of vaccine-preventable, non-vaccine-preventable, viral, and non-viral diseases among five vector-borne diseases in 2020 were compared with the previous five years in China. Table S4. Pairwise comparisons of the average monthly incidence of five vector-borne diseases for January to April in 2015–2019, 2020 and 2021. Table S5. Changes in the average yearly mortality rates of the vaccine-preventable, non-vaccine-preventable, viral, and non-viral diseases among five vector-borne diseases in 2020 compared with the previous five years in China. Table S6. Pairwise comparisons of the average monthly mortality rates of five vector-borne diseases for January to April in 2015–2019, 2020 and 2021. Table S7. Changes in the yearly incidence of five vector-borne diseases in 2020 between observed and predicted values. Table S8. Changes in the average monthly incidence of five vector-borne diseases in the emergency response stage (January to April 2020) and the routine response stage (May to December 2020) between observed and predicted values. Table S9. Changes in the yearly mortality rates of five vector-borne diseases in 2020 between observed and predicted values. Table S10. Changes in the average monthly mortality rates of five vector-borne diseases in the emergency response stage (January to April 2020) and the routine response stage (May to December 2020) between observed and predicted values.
Invariant functions on symplectic representations
Creators: name: Knop, Friedrich
Publisher: name: arXiv
Year: 2005
Subjects: subject: Algebraic Geometry (math.AG)
subject: Commutative Algebra (math.AC)
subject: Representation Theory (math.RT)
subject: Symplectic Geometry (math.SG)
subject: FOS: Mathematics
subject: 14L30; 13A50; 53D20

description: Let G be a connected reductive group. In this paper we are studying the invariant theory of symplectic G-modules. Our main result is that the invariant moment map is equidimensional. We deduce that the categorical quotient is a fibration over an affine space with rational generic fibers. Of particular interest are those modules for which the generic orbit is coisotropic. We prove that they are cofree. This result has been used in another paper (math.SG/0505268) to classify all these modules. Our main tool is a symplectic version of the local structure theorem.
description: v1: 24 pages; v2: 31 pages, expanded exposition, new introduction, some facts (esp. Thm. 7.2+Corollaries, Thm. 8.4) which were only implicit in v1 are now spelled out
Sequence-specific interactions in the RNA-binding domain of Escherichia coli transcription termination factor Rho.
Creators: name: T. Kevin  Hitchens
name: Yiping  Zhan
name: Lislott V. Richardson
name: Richardson, John P.
name: Rule, Gordon
Publisher: name: Carnegie Mellon University
Year: 2006
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Rho factor is an essential protein that causes termination of transcription in a wide variety of bacteria by an RNA-dependent helicase activity. Rho is activated by transcripts that contain a high proportion of cytidine residues. The interaction between Rho and two adjacent cytidine residues within the bound RNA has been identified by previous crystallographic studies (Skordalakes, E., and Berger, J. M. (2003) Cell 114, 135-146). In this study, NMR methods were used to investigate the sequence dependence of the binding of oligonucleotides to the RNA-binding domain of Rho protein (rho130). A comparison of the NMR spectra obtained for rho130 bound to single-stranded oligonucleotides ACTTCCA or ATTTCCA showed that the 5'-cytidine residue interacts with Rho at a site that is distinct from the CC binding site identified by crystallographic studies. Two amino acid residues within this new cytidine binding site, Arg(88) and Phe(89), were altered to Glu and Ser, respectively. These mutant forms of Rho were defective in transcriptional termination, suggesting that those residues play an important role in the activation of Rho by bound RNA.
Ligusticum scoticum Linnaeus 1759
Creators: name: Jarvis, Charlie
Publisher: name: Linnaean Society of London in association with the Natural History Museum
Year: 2007
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Apiales
Apiaceae
Ligusticum
Ligusticum scoticum

description: Ligusticum scoticum Linnaeus, Systema Naturae, ed. 10, 2: 958. 1759, orth. var.
["Habitat ad litora Maris in Anglia, Suecia."] Sp. Pl. 1: 250 (1753). RCN: 2010.
 Lectotype (Reduron & Jarvis in Jarvis & al., Regnum Veg. 127: 61. 1993): Herb. Clifford: 97, Ligusticum 3 (BM-000558302).
 Current name: Ligusticum scoticum L. (Apiaceae).
 Note: Evidently an orthographic variant of Ligusticum scothicum L. (1753). The species number and Linnaean polynomial are the same.
description: Published as part of Jarvis, Charlie, 2007, Chapter 7: Linnaean Plant Names and their Types (part L), pp. 610-650 in Order out of Chaos. Linnaean Plant Types and their Types, London :Linnaean Society of London in association with the Natural History Museum on page 632, DOI: 10.5281/zenodo.291971
Quantum-hydrodynamical picture of the massive Higgs boson
Creators: name: Consoli, M.
name: Costanzo, E.
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The phenomenon of spontaneous symmetry breaking admits a physical interpretation in terms of the Bose-condensation process of elementary spinless quanta. In this picture, the broken-symmetry phase emerges as a real physical medium, endowed with a hierarchical pattern of scales, supporting two types of elementary excitations for k \to 0: a massive energy branch E_a(k) \to M_H, corresponding to the usual Higgs boson field, and a collective gap-less branch E_b(k) \to 0. This is similar to the coexistence of phonons and rotons in superfluid He-4 that, in fact, is usually considered the condensed-matter analog of the Higgs condensate. After previous work dedicated to the properties of the gap-less, phonon branch, in this paper we use quantum hydrodynamics to propose a physical interpretation of the massive branch. On the base of our results, M_H coincides with the energy-gap for vortex formation and a massive Higgs boson is like a roton in superfluid He-4. Within this interpretation of the Higgs particle, there is no "naturalness" problem since M_H remains a naturally intermediate, fixed energy scale, even for an ultimate ultraviolet cutoff Lambda \to \infty.
description: Latex file, 20 pages, no figures
Star formation in low density HI gas around the Elliptical Galaxy NGC2865
Creators: name: Urrutia-Viscarra, F.
name: Torres-Flores, S.
name: de Oliveira, C. Mendes
name: Carrasco, E. R.
name: de Mello, D.
name: Arnaboldi, M.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Interacting galaxies surrounded by HI tidal debris are ideal sites for the study of young clusters and tidal galaxy formation. The process that triggers star formation in the low-density environments outside galaxies is still an open question. New clusters and galaxies of tidal origin are expected to have high metallicities for their luminosities. Spectroscopy of such objects is, however, at the limit of what can be done with existing 8-10m class telescopes, which has prevented statistical studies of these objects. NGC2865 is an UV-bright merging elliptical galaxy with shells and extended HI tails. The regions observed in this work were previously detected using multi-slit imaging spectroscopy. We obtain new multislit spectroscopy of six young star-forming regions around NGC2865, to determine their redshifts and metallicities. The six emission-line regions are located 16-40 kpc from NGC2865 and they have similar redshifts. They have ages of ~10Myears and an average metallicity of 12+log(O/H) ~ 8.6, suggesting a tidal origin for the regions. It is noted that they coincide with an extended HI tail, which has projected density of N$_{HI}$ < 10$^{19}$ cm$^{-2}$, and displays a low surface brightness counterpart. These regions may represent the youngest of the three populations of star clusters already identified in NGC2865. The high, nearly-solar, oxygen abundances found for the six regions in the vicinity of NGC2865 suggest that they were formed by pre-enriched material from the parent galaxy, from gas removed during the last major merger. Given the mass and the location of the HII regions, we can speculate that these young star-forming regions are potential precursors of globular clusters that will be part of the halo of NGC2865 in the future. Our result supports the use of the multi-slit imaging spectroscopy as a useful tool for finding nearly-formed stellar systems around galaxies.
description: 7 pages, 2 figures accepted in A&A
Can Centauros or Chirons be the first observations of evaporating mini black holes?
Creators: name: Mironov, A.
name: Morozov, A.
name: Tomaras, T. N.
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We argue that the signals expected from the evaporation of mini black holes - predicted in TeV-scale gravity models with large extra dimensions, and possibly produced in ultra high energy collisions in the atmosphere - are quite similar to the characteristics of the Centauro events, an old mystery of cosmic-ray physics.
description: 14 pages, LaTeX, one Table, uses rotate.sty and rotcapt.sty. References added, typos corrected, footnotes moved into the text
Probing the Evolution of IR Properties of z~6 Quasars: Spitzer Observations
Creators: name: Jiang, Linhua
name: Fan, Xiaohui
name: Hines, Dean C.
name: Shi, Yong
name: Vestergaard, Marianne
name: Bertoldi, Frank
name: Brandt, W. N.
name: Carilli, Chris L.
name: Cox, Pierre
name: Floc'h, Emeric Le
name: Pentericci, Laura
name: Richards, Gordon T.
name: Rieke, George H.
name: Schneider, Donald P.
name: Strauss, Michael A.
name: Walter, Fabian
name: Brinkmann, J.
Publisher: name: arXiv
Year: 2006
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present Spitzer observations of thirteen z~6 quasars using the Infrared Array Camera (IRAC) and Multiband Imaging Photometer for Spitzer (MIPS). All the quasars except SDSS J000552.34-000655.8 (SDSS J0005-0006) were detected with high S/N in the four IRAC channels and the MIPS 24um band, while SDSS J0005-0006 was marginally detected in the IRAC 8.0um band, and not detected in the MIPS 24um band. We find that most of these quasars have prominent emission from hot dust as evidenced by the observed 24um fluxes. Their spectral energy distributions (SEDs) are similar to those of low-redshift quasars at rest-frame 0.15-3.5 um, suggesting that accretion disks and hot-dust structures for these sources already have reached maturity. However, SDSS J0005-0006 has an unusual SED that lies significantly below low-redshift SED templates at rest-frame 1 and 3.5 um, and thus shows a strong near-IR (NIR) deficit and no hot-dust emission. Type I quasars with extremely small NIR-to-optical flux ratios like SDSS J0005-0006 are not found in low-redshift quasar samples, indicating that SDSS J0005-0006 has different dust properties at high redshift. We combine the Spitzer observations with X-ray, UV/optical, mm/submm and radio observations to determine bolometric luminosities for all the quasars. We find that the four quasars with central black-hole mass measurements have Eddington ratios of order unity.
description: 22 pages, 5 figures, accepted by AJ