Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
Creators: name: Ong, Ken K.
name: Smith, Blair H.
name: McKnight, Barbara
name: Pe'russe, Louis
name: Grabe, Hans-Jörgen
name: Marques-Vidal, Pedro
name: Kooner, Jaspal S.
name: Wareham, Nicholas J.
name: Morris, Andrew P.
name: Grammer, Tanja B.
name: Chittani, Martina
name: Hassinen, Maija
name: Trompet, Stella
name: Juonala, Markus
name: Kooperberg, Charles
name: Peters, Annette
name: Wu, Joseph
name: Kuusisto, Johanna
name: Zillikens, M. Carola
name: Bruinenberg, Marcel
name: Eriksson, Anna L.
name: Manichaikul, Ani
name: Fox, Caroline S.
name: Snieder, Harold
name: Barata, Llilda
name: Vestergaard, Henrik
name: Polasek, Ozren
name: Borecki, Ingrid B.
name: Martin, Nicholas G.
name: Ahluwalia, Tarunveer S.
name: Sattar, Naveed
name: Mellström, Dan
name: Franks, Paul W.
name: Hirschhorn, Joel N.
name: Stringham, Heather M.
name: Kivimaki, Mika
name: Jarvelin, Marjo-Riitta
name: Cucca, Francesco
name: Chu, Audrey Y.
name: Hocking, Lynne J.
name: Holmen, Oddgeir L.
name: Corre, Tanguy
name: Männikkö, Reija
name: Jukema, J. Wouter
name: Tuomilehto, Jaakko
name: Pasterkamp, Gerard
name: Wolffenbuttel, Bruce H.R.
name: Hernandez, Dena
name: James, Alan L.
name: Ford, Ian
name: Heid, Iris M.
name: Barroso, Inês
name: Rawal, Rajesh
name: Amin, Najaf
name: Hartman, Catharina A.
name: Tayo, Bamidele O.
name: Gertow, Karl
name: Direk, Nese
name: Lorentzon, Mattias
name: Esko, Toñu
name: Eriksson, Joel
name: Afaq, Saima
name: Van Duijn, Cornelia M.
name: Waldenberger, Melanie
name: Balkau, Beverley
name: Gong, Jian
name: Pervjakova, Natalia
name: Young, Kristin
name: Baldassarre, Damiano
name: Yengo, Loic
name: Justice, Anne E.
name: Luan, Jian'an
name: Teumer, Alexander
name: Gigante, Bruna
name: Horikoshi, Momoko
name: Launer, Lenore J.
name: Grallert, Harald
name: Ngwa, Julius S.
name: Wu, Ying
name: Ludolph-Donislawski, Anja
name: Rao, 
name: Thuillier, Dorothee
name: Renström, Frida
name: Hindorff, Lucia
name: Chines, Peter S.
name: Lobbens, Stephane
name: Kanoni, Stavroula
name: Müller-Nurasyid, Martina
name: Jansson, John-Olov
name: Navarro, Pau
name: De Geus, Eco J.C.
name: Rose, Lynda M.
name: Savonen, Kai
name: Lim, Unhee
name: Hunter, David J.
name: Sarti, Cinzia
name: Bielak, Lawrence F.
name: Rauramaa, Rainer
name: Whitfield, John B.
name: Hastie, Nicholas D.
name: Bandinelli, Stefania
name: Swertz, Morris A.
name: Cooper, Richard S.
name: Swift, Amy J.
name: Kähönen, Mika
name: Deng, Xuan
name: Gorski, Mathias
name: De Faire, Ulf
name: Karlsson, Magnus
name: Siemelink, Marten A.
name: Narisu, Narisu
name: Johnson, Andrew D.
name: Lubke, Gitta
name: Wong, Andrew
name: Perez, Jeremiah
name: Verweij, Niek
name: Grarup, Niels
name: Scholtens, Salome
name: Kvaloy, Kirsti
name: McCarthy, Mark I.
name: Boerwinkle, Eric
name: Laakso, Markku
name: Bakker, Stephan J.L.
name: Tyrrell, Jessica
name: Chasman, Daniel I.
name: De Craen, Anton J.M.
name: Chambers, John C.
name: Krämer, Bernhard K.
name: Huang, Tao
name: Eicher, John D.
name: Hutri-Kähönen, Nina
name: Loh, Marie
name: Bergmann, Sven
name: Weir, David R.
name: Nauck, Matthias
name: März, Winfried
name: Lindgren, Cecilia M.
name: Smith, Jennifer A.
name: Middelberg, Rita P.S.
name: Kutalik, Zolta'n
name: Qi, Qibin
name: Spector, Tim D.
name: Hveem, Kristian
name: Psaty, Bruce M.
name: Bergman, Richard N.
name: Hansen, Torben
name: Homuth, Georg
name: Strawbridge, Rona J.
name: Strauch, Konstantin
name: Haitjema, Saskia
name: Zhang, Weihua
name: Jackson, Anne U.
name: Buckley, Brendan M.
name: De Borst, Gert J.
name: Staessen, Jan A.
name: Vollenweider, Peter
name: Liu, Ching-Ti
name: Schurmann, Claudia
name: Cupples, L. Adrienne
name: Marchini, Jonathan
name: Ohlsson, Claes
name: Wright, Alan F.
name: Wild, Sarah
name: Hollensted, Mette
name: North, Kari E.
name: Bragg, Jennifer
name: Hung, Joseph
name: Gordon-Larsen, Penny
name: Koistinen, Heikki A.
name: Olden, Matthias
name: Fischer, Krista
name: Hottenga, Jouke Jan
name: Thorand, Barbara
name: Harder, Marie Neergaard
name: Silbernagel, Günther
name: Huffman, Jennifer E.
name: Hallmans, Göran
name: Nolte, Ilja M.
name: Le Marchand, Loic
name: Zimmermann, Martina E.
name: Coggeshall, Scott
name: Boomsma, Dorret I.
name: Strachan, David P.
name: Qi, Lu
name: Jorgensen, Marit E.
name: Cadby, Gemma
name: Vandenput, Liesbeth
name: Tremoli, Elena
name: Porteous, David J.
name: Abecasis, Gonçalo R.
name: McKenzie, Colin A.
name: Dedoussis, George
name: Kuh, Diana
name: Hamsten, Anders
name: Bonnycastle, Lori L.
name: Linneberg, Allan
name: Van Der Laan, Sander W.
name: Rasmussen-Torvik, Laura J.
name: Lind, Lars
name: Faul, Jessica D.
name: Winkler, Thomas W.
name: Jhun, Min A.
name: Westendorp, 
name: Zhao, Jing Hua
name: Sung, Yun Ju
name: Kolovou, Genovefa
name: Rudan, Igor
name: Langenberg, Claudia
name: Kardia, Sharon L.R.
name: Madden, Pamela A.F.
name: Curran, Joanne E.
name: Afzal, Uzma
name: Mahajan, Anubha
name: Lyytikäinen, Leo-Pekka
name: Adair, Linda S.
name: Alfred, Tamuno
name: Van Der Harst, Pim
name: Mohlke, Karen L.
name: Völzke, Henry
name: Cusi, Daniele
name: Peyser, Patricia A.
name: Frayling, Timothy M.
name: Komulainen, Pirjo
name: Ferrucci, Luigi
name: Stanča'kova, Alena
name: Eiriksdottir, Gudny
name: Metspalu, Andres
name: Scott, Robert A.
name: Ida Chen, Yii-Der
name: Fisher, Virginia A.
name: Lupoli, Sara
name: Ahmad, Shafqat
name: Bartz, Traci M.
name: Campbell, Harry
name: Peters, Ulrike
name: Van Vliet-Ostaptchouk, Jana V.
name: Blangero, John
name: Musk, 
name: Tanaka, Toshiko
name: Rankinen, Tuomo
name: Kilpeläinen, Tuomas O.
name: Sanna, Serena
name: Boehnke, Michael
name: Harris, Tamara B.
name: Kleber, Marcus E.
name: Ridker, Paul M.
name: Kinnunen, Leena
name: Hayward, Caroline
name: Menni, Cristina
name: Braga, Daniele
name: Tiemeier, Henning
name: Böger, Carsten A.
name: Vitart, Veronique
name: Rice, Treva
name: Zhao, Wei
name: Taylor, Kent D.
name: Deloukas, Panagiotis
name: Vink, Jacqueline M.
name: Graff, Misa
name: Wilson, James F.
name: Sorensen, Thorkild I.A.
name: Vedantam, Sailaja L.
name: Biffar, Reiner
name: Kolcic, Ivana
name: Willemsen, Gonneke
name: Bonnefond, Amelie
name: Vonk, Judith M.
name: Glorioso, Nicola
name: Lakka, Timo A.
name: Xue, Luting
name: Lim, Elise
name: Heath, Andrew C.
name: Loos, Ruth J.F.
name: Haiman, Christopher A.
name: Palmer, Lyle J.
name: Forrester, Terrence
name: Sennblad, Bengt
name: Van Der Most, Peter J.
name: Gudnason, Vilmundur
name: Collins, Francis S.
name: Lee, Nanette R.
name: Leander, Karin
name: Delgado, Graciela E.
name: Beilby, John
name: Luben, Robert
name: Bien, Stephanie A.
name: Pisinger, Charlotta
name: Uitterlinden, Andre G.
name: Oldehinkel, Albertine J.
name: Zubair, Niha
name: Montgomery, Grant W.
name: Vohl, Marie-Claude
name: Mangino, Massimo
name: Sarzynski, Mark A.
name: Waeber, Ge'rard
name: Raitakari, Olli T.
name: Justesen, Johanne Marie
name: Hadley, David
name: Smith, Albert Vernon
name: Kumari, Meena
name: Schlessinger, David
name: Lehtimäki, Terho
name: Feitosa, Mary F.
name: Heard-Costa, Nancy L.
name: Den Ruijter, Hester M.
name: Bottinger, Erwin
name: Padmanabhan, Sandosh
name: Czajkowski, Jacek
name: Pedersen, Oluf
name: Bouchard, Claude
name: Slagboom, P. Eline
name: Buyske, Steve
name: Stott, David J.
name: Marten, Jonathan
name: Froguel, Philippe
name: Huang, Jie
name: Ingelsson, Erik
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.