Additional file 1 of Dyslipidemia induced large-scale network connectivity abnormality facilitates cognitive decline in the Alzheimer’s disease
Creators: name: Wang, Qing
name: Zang, Feifei
name: He, Cancan
name: Zhang, Zhijun
name: Xie, Chunming
Publisher: name: figshare
Year: 2024
Subjects: Biochemistry
Medicine
Cell Biology
Neuroscience
Pharmacology
Mental Health
Computational Biology

description: Additional file 1: Table. S1 Summary of multiple SNPs based on GWAS and large-scale meta-analyses for lipid pathway-based genotypes. Table. S2 Concentrations of cholesterol metabolites in blood correlated with cognition across the AD spectrum. Table. S3 Anatomical locations of the 226 regions of interest used to characterize the 10 resting-state networks. Table. S4 Canonical correlation coefficients and p values within- and between the ten predefined RSNs. Table. S5 Canonical correlation coefficients and p values of lipid-related genetic scores and lipoproteins. Table. S6 Post hoc analysis revealed correlation coefficients and p values among lipid-related genetic scores and lipoproteins, large-scale network connectivity, CSF biomarkers, and cognitive performance. Table. S7 Twenty-two functional connection links used for classification between groups. Table. S8 Modified model fit indices. Table S9 Results of Structural Path model of direct effects. Figure. S1 Nonlinear curves fitted between cerebrospinal fluid biomarkers and global cognitive performance. Abbreviations: MMSE, mini-mental state examination; ADAS-cog, Alzheimer’s disease assessment scale-cognitive section; Aβ, amyloid 1 to 42 peptide; Tau, total tau; pTau, tau phosphorylated at the threonine 181 position; CSF, cerebrospinal fluid. Figure. S2 Correlations and their significance between the following in patients with EMCI, LMCI and AD: the two clinical cognitive performance variables and clinical CCA mode (A); the three cerebrospinal fluid biomarker variables and CSF CCA mode (B); fifty-five within and pairwise between-network variables and network CCA mode (C); first pairwise CCA mode (D), and second pairwise CCA mode (E). Note P values in A, B and C, have been log10-transformed. Red dashed lines represent a log10-transformed P value of 0.05. Abbreviations: MMSE, mini-mental state examination; ADAS-cog, Alzheimer’s disease assessment scale-cognitive section; Aβ, amyloid 1 to 42 peptide; Tau, total tau; pTau, tau phosphorylated at the threonine 181 position; CSF, cerebrospinal fluid; CCA, canonical correlation analysis. Figure. S3 Correlations and their significance between the following in patients with EMCI, LMCI and AD: the three gene score variables and the second gene CCA mode (A), the thirty-eight serum lipid variables and serum lipid CCA mode (B), the fifth pairs of CCA modes (C) and sixth pairs of CCA modes (D). All data for cholesterol metabolites in the blood were z-transformed. Note that the P values in A and B were log10-transformed. Red dashed lines represent a log10-transformed P value of 0.05. Abbreviations: GPS, genetic protective score; GRS_n, genetic risk score without APOE ε4; RRS, relative risk score without APOE ε4; CCA, canonical correlation analysis. Figure. S4 Radar plots indicating patterns of association for serum lipid, cognitive performance, CSF biomarkers, and polygenic scores to network connectivity. Values displayed by the dots in the radar plots are values of Pearson’s correlation coefficients. All nodes represent a statistically significant correlation coefficient (p value&lt;0.05). Abbreviations: AUD, the auditory network; CON, the cingulo-opercular network; DAN, the dorsal attention network; DMN, the default mode network; FPN, the fronto-parietal network; SAN, the salience network; SMN, the sensory network; SUB, the subcortical network; VAN, the ventral attention network; VIS, the visual network; LDL, low density lipoprotein; MMSE, mini-mental state examination; ADAS-cog, Alzheimer’s disease assessment scale-cognitive section; Tau, total tau; GPS, genetic protective score; GRS, genetic risk score; RRS, relative risk score. The abbreviations of plasma cholesterol metabolites were are provided. Figure. S5 Radar plots demonstrating patterns of association of cognitive performance, CSF biomarkers, and gene scores to network connectivity. Values displayed by the dots in the radar plots are values of Pearson’s correlation coefficients. All nodes represent a statistically significant correlation coefficient (p value&lt;0.05). Abbreviations: AUD, the auditory network; DAN, the dorsal attention network; FPN, the fronto-parietal network; SAN, the salience network; SUB, the subcortical network; VAN, the ventral attention network; MMSE, mini-mental state examination; ADAS-cog, Alzheimer’s disease assessment scale-cognitive section; Tau, total tau; GPS, genetic protective score; GRS_n, genetic risk score without APOE ε4.