cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Evaluation of an IMU-Based Wearable Device for ACL Injury ResearchAdvances in Orthopedics and Sports Medicine (AOASM) Journal Publication
Creators: name: Kresie, Scott
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 400303
subject: Biomechanical engineering
classificationCode: 420701
subject: Biomechanics
classificationCode: 340607
subject: Reaction kinetics and dynamics
classificationCode: 400906
subject: Electronic sensors
classificationCode: 420604
subject: Injury prevention

description: Anterior cruciate ligament (ACL) injuries are common, costly and have long-term health consequences. Despite decades of ACL injury research, ACL injury incidence remains high, highlighting the need for new approaches. We hypothesize that many non-contact ACL injuries result from an overuse, fatigue failure mechanism and that advances in wearable technology provide an exciting opportunity to obtain data needed to test this hypothesis. In this study, we created and evaluated an inertial measurement unit (IMU) based wearable device to collect a clinically relevant metric of ACL loading events from athletes in the field. The wearable device measures relative anterior tibial acceleration (RATA), a surrogate measure of ACL loading defined as the relative acceleration between a point on the proximal tibia and a point on the distal femur. The device was evaluated using a mechanical test system designed to simulate human leg movement, and then used to quantify peak RATA profiles for two participants performing six common athletic movement tasks associated with relatively low and high levels of ACL loading. The wearable device successfully tracked in-vivo the frequency and magnitude of ACL loading events and thus provides a tool to acquire data needed to test fatigue failure mechanism theories of ACL injury.
Multivalent ion-mediated nucleic acid helix-helix interactions: RNA versus DNA
Creators: name: Wu, Yuan-Yan
name: Zhang, Zhong-Liang
name: Zhang, Jin-Si
name: Zhu, Xiao-Long
name: Tan, Zhi-Jie
Publisher: name: arXiv
Year: 2015
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: Ion-mediated interaction is critical to the structure and stability of nucleic acids. Recent experiments suggest that the multivalent ion-induced aggregation of double-stranded (ds) RNAs and DNAs may strongly depend on the topological nature of helices, while there is still lack of an understanding on the relevant ion-mediated interactions at atomistic level. In this work, we have directly calculated the potentials of mean force (PMF) between two dsRNAs and between two dsDNAs in Cobalt Hexammine ion (Co-Hex) solutions by the atomistic molecular dynamics simulations. Our calculations show that at low [Co-Hex], the PMFs between B-DNAs and between A-RNAs are both (strongly) repulsive.However, at high [Co-Hex], the PMF between B-DNAs is strongly attractive, while those between A-RNAs and between A-DNAs are still (weakly) repulsive. The microscopic analyses show that for A-form helices, Co-Hex would become internal binding into the deep major groove and consequently cannot form the evident ion-bridge between adjacent helices, while for B-form helices without deep grooves, Co-Hex would exhibit external binding to strongly bridge adjacent helices. In addition, our further calculations show that, the PMF between A-RNAs could become strongly attractive either at very high [Co-Hex] or when the bottom of deep major groove is fixed with a layer of water.
title: The role of computed tomography in aortic dissection
Creators: name: Mota, Alexandre
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Complications
subject: Diagnostic procedure
subject: CT
subject: Arteries / Aorta
subject: Dissection

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To review the role of computed tomography (CT) in establishing the diagnosis, prognosis and treatment for aortic dissection (AD). To illustrate common and uncommon CT findings of AD and understand their usefulness. To illustrate the different...
Eye-voice span during rapid automatized naming: evidence of reduced automaticity in individuals with autism spectrum disorder and their siblings
Creators: name: Hoedemaker, Renske S
name: Gordon, Peter
Publisher: name: BioMed Central Ltd
Year: 2014

description: Abstract Background Individuals with autism spectrum disorder (ASD) and their parents demonstrate impaired performance in rapid automatized naming (RAN), a task that recruits a variety of linguistic and executive processes. Though the basic processes that contribute to RAN differences remain unclear, eye-voice relationships, as measured through eye tracking, can provide insight into cognitive and perceptual processes contributing to RAN performance. For example, in RAN, eye-voice span (EVS), the distance ahead the eyes are when articulation of a target item's label begins, is an indirect measure of automaticity of the processes underlying RAN. The primary objective of this study was to investigate automaticity in naming processes, as indexed by EVS during RAN. The secondary objective was to characterize RAN difficulties in individuals with ASD and their siblings. Methods Participants (aged 15–33 years) included 21 individuals with ASD, 23 siblings of individuals with ASD, and 24 control subjects, group-matched on chronological age. Naming time, frequency of errors, and EVS were measured during a RAN task and compared across groups. Results A stepwise pattern of RAN performance was observed, with individuals with ASD demonstrating the slowest naming across all RAN conditions, controls demonstrating the fastest naming, and siblings demonstrating intermediate performance. Individuals with ASD exhibited smaller EVSs than controls on all RAN conditions, and siblings exhibited smaller EVSs during number naming (the most highly automatized type of naming). EVSs were correlated with naming times in controls only, and only in the more automatized conditions. Conclusions These results suggest that reduced automaticity in the component processes of RAN may underpin differences in individuals with ASD and their siblings. These findings also provide further support that RAN abilities are impacted by genetic liability to ASD. This study has important implications for understanding the underlying skills contributing to language-related deficits in ASD.
title: Pancreatic hypervascular lesions: Neuroendocrine tumors and beyond
Creators: name: Pereira, Pedro
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Cancer
subject: eLearning
subject: Education
subject: MR
subject: CT
subject: Pancreas
subject: Oncology
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Review the range of appearances of pancreatic neuroendocrine tumors; Illustrate pertinent imaging findings of other pancreatic hypervascular lesions that aid in the differential...
Isospin effects in N~Z nuclei in extended Density Functional Theory
Creators: name: Satula, Wojciech
name: Nazarewicz, Witold
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: This paper overviews various phenomena related to the concept of isospin symmetry. The focus is on N~Z nuclei, which are excellent laboratories of isospin physics. The theoretical framework applied is nuclear Density Functional Theory and its isospin- and angular-momentum projected extensions, as well as symmetry-projected multi-reference models. The topics covered include: isospin impurities, superallowed beta decays, beta-transitions in mirror nuclei, isospin breaking hadronic interactions, mirror and triplet binding energy differences, and isoscalar pairing.
description: submitted to Physica Scripta to the Focus Issue on Nuclear Structure: Celberating the 75 Nobel Prize
Recombinant ecto-5'-nucleotidase (CD73) has long lasting antinociceptive effects that are dependent on adenosine A1 receptor activation
Creators: name: Sowa, Nathaniel A
name: Zylka, Mark J.
name: Voss, Meagen K
Publisher: name: BioMed Central Ltd
Year: 2010

description: Abstract Background Ecto-5'-nucleotidase (NT5E, also known as CD73) hydrolyzes extracellular adenosine 5'-monophosphate (AMP) to adenosine in nociceptive circuits. Since adenosine has antinociceptive effects in rodents and humans, we hypothesized that NT5E, an enzyme that generates adenosine, might also have antinociceptive effects in vivo. Results To test this hypothesis, we purified a soluble version of mouse NT5E (mNT5E) using the baculovirus expression system. Recombinant mNT5E hydrolyzed AMP in biochemical assays and was inhibited by α,β-methylene-adenosine 5'-diphosphate (α,β-me-ADP; IC50 = 0.43 μM), a selective inhibitor of NT5E. mNT5E exhibited a dose-dependent thermal antinociceptive effect that lasted for two days when injected intrathecally in wild-type mice. In addition, mNT5E had thermal antihyperalgesic and mechanical antiallodynic effects that lasted for two days in the complete Freund's adjuvant (CFA) model of inflammatory pain and the spared nerve injury (SNI) model of neuropathic pain. In contrast, mNT5E had no antinociceptive effects when injected intrathecally into adenosine A1 receptor (A1R, Adora1) knockout mice. Conclusion Our data indicate that the long lasting antinociceptive effects of mNT5E are due to hydrolysis of AMP followed by activation of A1R. Moreover, our data suggest recombinant NT5E could be used to treat chronic pain and to study many other physiological processes that are regulated by NT5E.
title: Radiological appearance of brain metastases in EGFR-mutated non-small cell lung cancer
Creators: name: Abdulla, Sarah
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Metastases
subject: Chemotherapy
subject: MR
subject: CT
subject: Oncology
subject: Lung
subject: CNS

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To compare the radiological appearances of brain metastases at diagnosis and during tyrosine-kinase inhibitors (TKIs) treatment in EGFR-mutated non-small cell lung cancer...
Independent measurement of the Hoyle state $β$ feeding from 12B using Gammasphere
Creators: name: Munch, M.
name: Alcorta, M.
name: Fynbo, H. O. U.
name: Albers, M.
name: Almaraz-Calderon, S.
name: Avila, M. L.
name: Ayangeakaa, A. D.
name: Back, B. B.
name: Bertone, P. F.
name: Carnelli, P. F. F.
name: Carpenter, M. P.
name: Chiara, C. J.
name: Clark, J. A.
name: DiGiovine, B.
name: Greene, J. P.
name: Harker, J. L.
name: Hoffman, C. R.
name: Hubbard, N. J.
name: Jiang, C. L.
name: Kirsebom, O. S.
name: Lauritsen, T.
name: Laursen, K. L.
name: Marley, S. T.
name: Nair, C.
name: Nusair, O.
name: Santiago-Gonzalez, D.
name: Sethi, J.
name: Seweryniak, D.
name: Talwar, R.
name: Ugalde, C.
name: Zhu, S.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Using an array of high-purity Compton-suppressed germanium detectors, we performed an independent measurement of the $β$-decay branching ratio from $^{12}\mathrm{B}$ to the second-excited (Hoyle) state in $^{12}\mathrm{C}$. Our result is $0.64(11)\%$, which is a factor $\sim 2$ smaller than the previously established literature value, but is in agreement with another recent measurement. This could indicate that the Hoyle state is more clustered than previously believed. The angular correlation of the Hoyle state $γ$ cascade has also been measured for the first time. It is consistent with theoretical predictions.
Altered reward system reactivity for personalized circumscribed interests in autism
Creators: name: Mosner, Maya G
Publisher: name: BioMed Central
Year: 2018

description: Abstract Background Neurobiological research in autism spectrum disorders (ASD) has paid little attention on brain mechanisms that cause and maintain restricted and repetitive behaviors and interests (RRBIs). Evidence indicates an imbalance in the brain’s reward system responsiveness to social and non-social stimuli may contribute to both social deficits and RRBIs. Thus, this study’s central aim was to compare brain responsiveness to individual RRBI (i.e., circumscribed interests), with social rewards (i.e., social approval), in youth with ASD relative to typically developing controls (TDCs). Methods We conducted a 3T functional magnetic resonance imaging (fMRI) study to investigate the blood-oxygenation-level-dependent effect of personalized circumscribed interest rewards versus social rewards in 39 youth with ASD relative to 22 TDC. To probe the reward system, we employed short video clips as reinforcement in an instrumental incentive delay task. This optimization increased the task’s ecological validity compared to still pictures that are often used in this line of research. Results Compared to TDCs, youth with ASD had stronger reward system responses for CIs mostly within the non-social realm (e.g., video games) than social rewards (e.g., approval). Additionally, this imbalance within the caudate nucleus’ responsiveness was related to greater social impairment. Conclusions The current data support the idea of reward system dysfunction that may contribute to enhanced motivation for RRBIs in ASD, accompanied by diminished motivation for social engagement. If a dysregulated reward system indeed supports the emergence and maintenance of social and non-social symptoms of ASD, then strategically targeting the reward system in future treatment endeavors may allow for more efficacious treatment practices that help improve outcomes for individuals with ASD and their families.
title: Imaging findings in pulmonary hypertension and its underlying etiological mechanisms.
Creators: name: Ferrufino, María
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Hypertension
subject: Education and training
subject: Diagnostic procedure
subject: Conventional radiography
subject: CT-Angiography
subject: CT
subject: Cardiovascular system
subject: Lung
subject: Pulmonary vessels

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The purpose of our educational exhibit is to: Describe imaging findings in the diagnosis and management of pulmonary hypertension (PH). List the main causes of pulmonary hypertension with reference to the underlying pathophysiologic mechanisms....
Electron waiting times for the mesoscopic capacitor
Creators: name: Hofer, Patrick P.
name: Dasenbrook, David
name: Flindt, Christian
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We evaluate the distribution of waiting times between electrons emitted by a driven mesoscopic capacitor. Based on a wave packet approach we obtain analytic expressions for the electronic waiting time distribution and the joint distribution of subsequent waiting times. These semi-classical results are compared to a full quantum treatment based on Floquet scattering theory and good agreement is found in the appropriate parameter ranges. Our results provide an intuitive picture of the electronic emissions from the driven mesoscopic capacitor and may be tested in future experiments.
description: 11 pages, 7 figures, invited contribution to special issue in Physica E on "Frontiers in quantum electronic transport - in memory of Markus B\"uttiker"
A new formula for the energy of bulk superconductivity
Creators: name: Kachmar, Ayman
Publisher: name: arXiv
Year: 2015
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: The energy of a type II superconductor submitted to an external magnetic field of intensity close to the second critical field is given by the celebrated Abrikosov energy. If the external magnetic field is comparable to and below the second critical field, the energy is given by a reference function obtained as a special (thermodynamic) limit of a non-linear energy. In this note, we give a new formula for this reference energy. In particular, we obtain it as a special limit of a {\it linear} energy defined over configurations normalized in the $L^4$-norm.
Selective Adaptation to Socially-Induced Percepts: Voice Gender 3
Creators: name: Wilbanks, Eric
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Linguistics
subject: FOS: Languages and literature
subject: Phonetics and Phonology
subject: Psycholinguistics and Neurolinguistics
subject: Social and Behavioral Sciences
subject: perception
subject: phonetics
subject: sociolinguistics

description: This repository contains the preregistration materials outlining the predictions, experimental methods, stimuli, and research outputs of a speech perception experiment.
ניסויית- כיצד חרדה ועומס קוגניטיבי משפיעים על ספונטניות?
Creators: name: azulay, Noa
name: Avisar, Dar
name: peleg, Itai
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: ״זוהי הרשמה מראש למחקר שלנו, תחת קורס ״ניסויית
750 GeV Di-photon excess at CERN LHC from a dark sector assisted scalar decay
Creators: name: Bhattacharya, Subhaditya
name: Patra, Sudhanwa
name: Sahoo, Nirakar
name: Sahu, Narendra
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present a simple extension of the standard model (SM) to explain the diphoton excess, reported by CMS and ATLAS at CERN LHC. The SM is extended by a dark sector including a vector-like lepton doublet and a singlet of zero electromagnetic charge, which are odd under a $Z_2$ symmetry. These vector-like leptons assist the additional scalar, different from SM Higgs, to decay to di-photons of invariant mass around 750 GeV and thus explaining the excess observed at LHC. The admixture of neutral component of the vector-like lepton doublet and singlet constitute the dark matter component of the Universe. We show the relevant parameter space for correct relic density and direct detection of dark matter.
description: 20 pages, 11 figures, accepted for publication in JCAP
title: MR spectroscopy in breast cancer: retrospective study of a population with high prevalence of disease
Creators: name: De Falco Alfano, Daniele
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Cancer
subject: Diagnostic procedure
subject: MR-Spectroscopy
subject: Breast

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Aim of the present study is to evaluate the correlation between histologic grading of breast carcinoma and presence of choline peak ( tCho) using MR spetroscopy...
Nanoscale Nonlinear Radio Frequency Properties of Bulk Nb : Origins of Extrinsic Nonlinear Effects
Creators: name: Tai, Tamin
name: Ghamsari, B. G.
name: Bieler, T.
name: Anlage, Steven M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: The performance of Niobium-based Superconducting Radio Frequency (SRF) particle accelerator cavities can be sensitive to localized defects that give rise to quenches at high accelerating gradients. In order to identify these material defects on bulk Nb surfaces at their operating frequency and temperature, a wide bandwidth microwave microscope with localized and strong RF magnetic fields is developed by integrating a magnetic write head into the near-field microwave microscope to enable mapping of the local electrodynamic response in the multi-GHz frequency regime at cryogenic temperatures. This magnetic writer demonstrates a localized and strong RF magnetic field on bulk Nb surface with $B_{surface}$ > 102 mT and sub-micron resolution. By measuring the nonlinear response of the superconductor, nonlinearity coming from the nano-scale weak link Josephson junctions due to the contaminated surface in the cavity fabrication process is demonstrated.
description: 10 pages, 13 figures
title: Bone Metastasis, despite everything!
Creators: name: Ng Wong, Yiken
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Metastases
subject: Education and training
subject: Cancer
subject: Education
subject: MR
subject: CT
subject: Conventional radiography
subject: Musculoskeletal spine
subject: Musculoskeletal bone
subject: Bones

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To describe unusual patterns of bone metatasis as they can be misdiagnosed as other injures in X-ray or CT examinations. To present uncommon manifestation of the bone metastasis based on the radiologic patterns. Show uncommon features of the bone...
Prospect Theory and Reference-Dependent Effort Costs
Creators: name: Braun, David
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Cognitive Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: decision making
subject: effort
subject: mental labor
subject: prospect theory
subject: value-based choice

description: This repository contains data and materials for a manuscript currently titled "Effort is Relatively Costly: Prospect Theory and Reference-Dependent Effort Costs",
Peripheral cueing modulation over Spatial Interference: Investigating the hypothesis of shared and specific attentional mechanisms triggered by Gaze and Arrows
Creators: name: Román-Caballero, Rafael
name: Lupiáñez, Juan
name: Casares, Marta
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Cognitive Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: The aim of the present study is to investigate whether a pre-cueing manipulation is also effective to reduce the standard congruency effect wit arrows (in valid trials) and at the same time make more negative the reversed congruency effect with eye gaze. We therefore expect similar results to the ones observed in the two experiments in Román-Caballero et al. (2021b) with the manipulation of the target–background synchrony.
Horocycle flow orbits and lattice surface characterizations
Creators: name: Chaika, Jon
name: Lindsey, Kathryn
Publisher: name: arXiv
Year: 2015
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 37A10, 37E35

description: The orbit closure of any translation surface under the horocycle flow in almost any direction equals its $SL_2(\mathbb{R})$ orbit closure. This result gives rise to new characterizations of lattice surfaces in terms of the hororcycle flow.
description: 20 pages
title: The importance of CT scan in acute mediastinitis
Creators: name: Lopez Martinez, Andrea
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Infection
subject: Diagnostic procedure
subject: CT
subject: Conventional radiography
subject: Mediastinum

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The aims of this exhibi were: To review the mediastinum anatomy and deep cervical fascia, to understand the different etiologicalprocesses of mediastinitis. To describe the findings of acute mediastinitis in conventional radiology, and specially in...
Interplay between nanometer-scale strain variations and externally applied strain in graphene
Creators: name: Verbiest, G. J.
name: Stampfer, C.
name: Huber, S. E.
name: Andersen, M.
name: Reuter, K.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We present a molecular modeling study analyzing nanometer-scale strain variations in graphene as a function of externally applied tensile strain. We consider two different mechanisms that could underlie nanometer-scale strain variations: static perturbations from lattice imperfections of an underlying substrate and thermal fluctuations. For both cases we observe a decrease in the out-of-plane atomic displacements with increasing strain, which is accompanied by an increase in the in-plane displacements. Reflecting the non-linear elastic properties of graphene, both trends together yield a non-monotonic variation of the total displacements with increasing tensile strain. This variation allows to test the role of nanometer-scale strain variations in limiting the carrier mobility of high-quality graphene samples.
Criteria for effective design, construction, and gene knockdown by shRNA vectors
Creators: name: Ting, Jenny P.-Y.
name: Conti, Brian J
name: Zhang, Jinghua
name: Taxman, Debra J
name: Williams, Kristi L
name: Reed, William
name: Livingstone, Laura R
name: Iocca, Heather A
name: Lich, John D
Publisher: name: BioMed Central Ltd
Year: 2006

description: Abstract Background RNA interference (RNAi) technology is a powerful methodology recently developed for the specific knockdown of targeted genes. RNAi is most commonly achieved either transiently by transfection of small interfering (si) RNA oligonucleotides, or stably using short hairpin (sh) RNA expressed from a DNA vector or virus. Much controversy has surrounded the development of rules for the design of effective siRNA oligonucleotides; and whether these rules apply to shRNA is not well characterized. Results To determine whether published algorithms for siRNA oligonucleotide design apply to shRNA, we constructed 27 shRNAs from 11 human genes expressed stably using retroviral vectors. We demonstrate an efficient method for preparing wild-type and mutant control shRNA vectors simultaneously using oligonucleotide hybrids. We show that sequencing through shRNA vectors can be problematic due to the intrinsic secondary structure of the hairpin, and we determine a strategy for effective sequencing by using a combination of modified BigDye chemistries and DNA relaxing agents. The efficacy of knockdown for the 27 shRNA vectors was evaluated against six published algorithms for siRNA oligonucleotide design. Our results show that none of the scoring algorithms can explain a significant percentage of variance in shRNA knockdown efficacy as assessed by linear regression analysis or ROC curve analysis. Application of a modification based on the stability of the 6 central bases of each shRNA provides fair-to-good predictions of knockdown efficacy for three of the algorithms. Analysis of an independent set of data from 38 shRNAs pooled from previous publications confirms these findings. Conclusion The use of mixed oligonucleotide pairs provides a time and cost efficient method of producing wild type and mutant control shRNA vectors. The addition to sequencing reactions of a combination of mixed dITP/dGTP chemistries and DNA relaxing agents enables read through the intrinsic secondary structure of problematic shRNA vectors. Six published algorithms for siRNA oligonucleotide design that were tested in this study show little or no efficacy at predicting shRNA knockdown outcome. However, application of a modification based on the central shRNA stability should provide a useful improvement to the design of effective shRNA vectors.
title: Deceptive anatomy: anatomic structures mimicking meniscus pseudotears
Creators: name: Jiménez, José Maria
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Musculoskeletal joint
subject: Musculoskeletal soft tissue
subject: Anatomy
subject: MR
subject: Diagnostic procedure
subject: Trauma
subject: Artifacts

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To depict and diferenciate potencial pitfalls of meniscus tears of the knee caused by anatomic...
Synchronized ion acceleration by ultraintense slow light
Creators: name: Brantov, A. V.
name: Govras, E. A.
name: Kovalev, V. F.
name: Bychenkov, V. Yu.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: An effective scheme of synchronized laser-triggered ion acceleration and the corresponding theoretical model are proposed for a slow light pulse of relativistic intensity, which penetrates into a near-critical-density plasma, strongly slows, and then increases its group velocity during propagation within a target. The 3D PIC simulations confirm this concept for proton acceleration by a femtosecond petawatt-class laser pulse experiencing relativistic self-focusing, quantify the characteristics of the generated protons, and demonstrate a significant increase of their energy compared with the proton energy generated from optimized ultrathin solid dense foils.
description: submitted to Phys.Rev.Lett
title: Interventional imaging of the bile ducts tumors
Creators: name: Lahkim, Mohamed
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Cancer
subject: Drainage
subject: Chemoembolisation
subject: Ablation procedures
subject: Ultrasound
subject: MR
subject: CT-High Resolution
subject: Interventional non-vascular
subject: Biliary Tract / Gallbladder
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: This poster reports the experience of the team of Ambroise Paré's Radiology department in the palliative interventional treatment of malignant tumors of the bile ducts with a review of the...
title: Common MRI artifacts: A practical approach
Creators: name: Duarte, Ana Luísa
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: MR physics
subject: MR
subject: Technical aspects
subject: Physics
subject: Artifacts

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To recognize the most common MRI artifacts. To know how to overcome this problem in order to reduce them, when possible, to obtain the best possible...
Erratum to: Monitoring iCCM referral systems: Bugoye Integrated Community Case Management Initiative (BIMI) in Uganda
Creators: name: Ntaro, Moses
name: Mbusa, Rapheal
name: Stone, Geren S
name: Miller, James S
name: Bwambale, Shem
name: English, Lacey
name: Matte, Michael
name: Kenney, Jessica
name: Patel, Palka
name: Mulogo, Edgar
Publisher: name: BioMed Central
Year: 2016

description: After publication of the original article [1], it came to the
authors’ attention that a sentence was inadvertently omitted
from the Acknowledgments section of the published
manuscript.
Tunable and direction-dependent group velocities in topologically protected edge states
Creators: name: Uhrig, Götz S.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Topological effects continue to fascinate physicists since more than three decades. One of their main applications are high-precision measurements of the resistivity. We propose to make also use of the spatially separated edge states. It is possible to realize strongly direction-dependent group velocities. They can also be tuned over orders of magnitude so that robust delay lines and interference devices are within reach.
description: 5 pages, 4 figures
Вестник научной мысли,Выпуск 8 2023
Creators: name: Дагестанский территориальный институт профессиональных бухгалтеров
Publisher: name: Дагестанский территориальный институт профессиональных бухгалтеров
Year: 2023

description: Вестник научной мысли,Выпуск 8 2023
title: Aortic valve planimetry by MRI: comparison with Echocardiography and Cardiac Catheterization
Creators: name: Borja Consigliere, Francisco
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Prostheses
subject: Comparative studies
subject: MR
subject: Cardiac

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The purpose of the present study is to determine intra- and inter-observer reliability of MRI aortic valve planimetry measurements, and to comparethe results with echocardiography and cardiac catheterization. Aortic stenosis (AS) has become the most...
title: What should you know about stapes?
Creators: name: Kaddour, Elyes
Publisher: name: European Congress of Radiology
Year: 2015
Subjects: subject: Ear / Nose / Throat
subject: CT-High Resolution
subject: Diagnostic procedure
subject: Congenital

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Stapes presents embryological and anatomical characteristics which differentiates it from other bones of the organism. Pathologies affecting this ossicle are varied and can be isolated or associated with other lesions of the ear. The aims of our...
Characterization of NF-kB-mediated inhibition of
catechol-O-methyltransferase
Creators: name: Wentworth, Sean
name: Qian, Li
name: Tchivileva, Inna E.
name: Conrad, Matthew
name: Diatchenko, Luda
name: Nackley, Andrea
Publisher: name: BioMed Central Ltd
Year: 2009

description: Abstract: Background: Catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, has recently been implicated in the modulation of pain. Specifically, low COMT activity is associated with heightened pain perception and development of musculoskeletal pain in humans as well as increased experimental pain sensitivity in rodents. Results: We report that the proinflammatory cytokine tumor necrosis factor α (TNFα) downregulates COMT mRNA and protein in astrocytes. Examination of the distal COMT promoter (P2-COMT) reveals a putative binding site for nuclear factor κB (NF-κB), the pivotal regulator of inflammation and the target of TNFα. Cell culture assays and functional deletion analyses of the cloned P2-COMT promoter demonstrate that TNFα inhibits P2-COMT activity in astrocytes by inducing NF-κB complex recruitment to the specific κB binding site. Conclusion: Collectively, our findings provide the first evidence for NF-κB-mediated inhibition of COMT expression in the central nervous system, suggesting that COMT contributes to the pathogenesis of inflammatory pain states.
Resonance-inclined optical nuclear spin polarization of liquids in diamond structures
Creators: name: Chen, Qiong
name: Schwarz, Ilai
name: Jelezko, Fedor
name: Retzker, Alex
name: Plenio, Martin B
Publisher: name: arXiv
Year: 2015
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Dynamic nuclear polarization (DNP) of molecules in a solution at room temperature has potential to revolutionize nuclear magnetic resonance spectroscopy and imaging. The prevalent methods for achieving DNP in solutions are typically most effective in the regime of small interaction correlation times between the electron and nuclear spins, limiting the size of accessible molecules. To solve this limitation, we design a mechanism for DNP in the liquid phase that is applicable for large interaction correlation times. Importantly, while this mechanism makes use of a resonance condition similar to solid-state DNP, the polarization transfer is robust to a relatively large detuning from the resonance due to molecular motion. We combine this scheme with optically polarized nitrogen vacancy (NV) center spins in nanodiamonds to design a setup that employs optical pumping and is therefore not limited by room temperature electron thermal polarisation. We illustrate numerically the effectiveness of the model in a flow cell containing nanodiamonds immobilized in a hydrogel, polarising flowing water molecules 4700-fold above thermal polarisation in a magnetic field of 0.35 T, in volumes detectable by current NMR scanners.
Noisy Question Asking (NQA) Study 2
Creators: name: Williams, Rondeline
name: Chuey, Aaron
name: Frank, Michael
name: Gweon, Hyowon
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Developmental Psychology
subject: Cognition and Perception
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: This study explores how background noise influences children’s understanding about others’ knowledge states. In study 2, we inform preschool-age children about two students’ knowledge states of novel toys- either students know nothing or everything about a toy- and then we manipulate which toy is masked by background noise. We then ask children which toy’s label and function will be repeated to the students. We hypothesize that older children will recognize that background noise hinders knowledge formation of previously unknown objects, but that it has no significant impact on previously known information. The purpose of this study is to understand how children make sense of knowledge formation under noise constraints.
β2-Adrenergic receptor promoter haplotype influences the severity of acute viral respiratory tract infection during infancy: a prospective cohort study
Creators: name: Islam, Jessica Y
Publisher: name: BioMed Central
Year: 2015

description: Abstract Background Despite the significant interest in β2-Adrenergic receptor (ADRB2) polymorphisms related to asthma, whether ADRB2 genetic variants are similarly associated with acute respiratory tract infections have not been studied. We hypothesized that genetic variants in ADRB2 associated with a response to asthma therapy during an asthma exacerbation were also associated with severity of acute respiratory tract infections. Methods To test this hypothesis, we genotyped 5 common polymorphisms in the promoter region and coding block of the ADRB2 gene (loci -2387, -2274, -1343, +46, and +79) from 374 Caucasian and African American term infants who were enrolled at the time of acute respiratory illness over four respiratory viral seasons. Severity of respiratory tract infections was measured using a bronchiolitis severity score (BSS; range = 0-12, clinically significant difference = 0.5) with a higher score indicating more severe disease. We assigned the promoter, coding and combined promoter and coding haplotypes to the unphased genotype data. The associations between each of these five single-nucleotide polymorphisms (SNPs) as well as the haplotypes and infant BSS were analyzed using nonparametric univariate analysis and multivariable proportional odds model separately in Caucasians and African Americans. Results There was no significant association between infant BSS and each of the SNPs in both Caucasians and African Americans. However, promoter haplotype CCA was associated with a decreased BSS in African Americans in a dose dependent manner. The median (interquartile range) BSS of infants with no copies of the CCA haplotype, one copy, and two copies of the CCA haplotype were 5.5 (2.0, 8.0), 4.0 (1.0, 7.5), and 3.0 (1.0, 4.0), respectively. This dose dependent relationship persisted after adjusting for infant age, gender, daycare exposure, secondhand smoke exposure, prior history of breastfeeding, siblings at home, and enrollment season (adjusted odds ratio: 0.59, 95 % confidence interval: 0.36, 0.98). There was no similar protective relationship of haplotype CCA on severity of respiratory tract infections identified in Caucasians. Conclusions ADRB2 genotype may be predictive of severity of acute respiratory tract infections in African Americans, and potentially identify a subset of infants who may respond to beta-agonist therapy.
Funding Open Infrastructure as a Public Utility: A Preliminary Investigation in Water Utility Funding
Creators: name: Enkhbayar, Asura
name: Dunks, Richard
Publisher: name: Zenodo
Year: 2022
Subjects: open infrastructure
financial sustainability
public utilities
water utilities
funding

description: In working to understand how a stable and reliable model for funding open infrastructure in research and scholarly communication could be architected, IOI looked at how public utilities, in particular water utilities, are funded around the world. Drawing on some of the preeminent literature and guidance on the topic from widely respected organizations (the OECD, WHO, and IRC), we attempt below to highlight some key lessons for funding a robust infrastructure of open services. Key to this is understanding knowledge as a public good, like water, electricity, and natural gas, and the means by which these vital public goods are best funded for reliable, robust, and sustainable supply in the long term.

description: This work was funded by Arcadia, a charitable fund of Lisbet Rausing and Peter Baldwin. Additional information about how our work is funded can be found here: https://investinopen.org/about/how-were-funded/
Residential self-selection bias in the estimation of built environment effects on physical activity between adolescence and young adulthood
Creators: name: Gordon-Larsen, Penny
name: Evenson, Kelly
name: Guilkey, David
name: Boone-Heinonen, Janne
Publisher: name: BioMed Central Ltd
Year: 2010

description: Abstract Background Built environment research is dominated by cross-sectional designs, which are particularly vulnerable to residential self-selection bias resulting from health-related attitudes, neighborhood preferences, or other unmeasured characteristics related to both neighborhood choice and health-related outcomes. Methods We used cohort data from the National Longitudinal Study of Adolescent Health (United States; Wave I, 1994-95; Wave III, 2001-02; n = 12,701) and a time-varying geographic information system. Longitudinal relationships between moderate to vigorous physical activity (MVPA) bouts and built and socioeconomic environment measures (landcover diversity, pay and public physical activity facilities per 10,000 population, street connectivity, median household income, and crime rate) from adolescence to young adulthood were estimated using random effects models (biased by unmeasured confounders) and fixed effects models (within-person estimator, which adjusts for unmeasured confounders that are stable over time). Results Random effects models yielded null associations except for negative crime-MVPA associations [coefficient (95% CI): -0.056 (-0.083, -0.029) in males, -0.061 (-0.090, -0.033) in females]. After controlling for measured and time invariant unmeasured characteristics using within-person estimators, MVPA was higher with greater physical activity pay facilities in males [coefficient (95% CI): 0.024 (0.006, 0.042)], and lower with higher crime rates in males [coefficient (95% CI): -0.107 (-0.140, -0.075)] and females [coefficient (95% CI): -0.046 (-0.083, -0.009)]. Other associations were null or in the counter-intuitive direction. Conclusions Comparison of within-person estimates to estimates unadjusted for unmeasured characteristics suggest that residential self-selection can bias associations toward the null, as opposed to its typical characterization as a positive confounder. Differential environment-MVPA associations by residential relocation suggest that studies examining changes following residential relocation may be vulnerable to selection bias. The authors discuss complexities of adjusting for residential self-selection and residential relocation, particularly during the adolescent to young adult transition.
Funding Open Infrastructure as a Public Utility: A Preliminary Investigation in Water Utility Funding
Creators: name: Enkhbayar, Asura
name: Dunks, Richard
Publisher: name: Zenodo
Year: 2023
Subjects: open infrastructure
financial sustainability
public utilities
water utilities
funding

description: In working to understand how a stable and reliable model for funding open infrastructure in research and scholarly communication could be architected, IOI looked at how public utilities, in particular water utilities, are funded around the world. Drawing on some of the preeminent literature and guidance on the topic from widely respected organizations (the OECD, WHO, and IRC), we attempt below to highlight some key lessons for funding a robust infrastructure of open services. Key to this is understanding knowledge as a public good, like water, electricity, and natural gas, and the means by which these vital public goods are best funded for reliable, robust, and sustainable supply in the long term.

description: This work was funded by Arcadia, a charitable fund of Lisbet Rausing and Peter Baldwin. Additional information about how our work is funded can be found here: https://investinopen.org/about/how-were-funded/
Dynamical description of heavy-ion collisions at Fermi energies
Creators: name: Napolitani, P.
name: Colonna, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Descriptions of heavy-ion collisions at Fermi energies require to take into account in-medium dissipation and phase-space fluctuations. The interplay of these correlations with the one-body collective behaviour determines the properties (kinematics and fragment production) and the variety of mechanisms (from fusion to neck formation and multifragmentation) of the exit channel. Starting from fundamental concepts tested on nuclear matter, we build up a microscopic description which addresses finite systems and applies to experimental observables.
description: 12th International Conference on Nucleus-Nucleus Collisions (NN2015) 21-26 June 2015, Catania, Italy