cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
IDENTIFICATION OF SIGNALING PATHWAYS ASSOCIATED WITH ACTIVATION OF THE MECHANOSENSITIVE CHANNEL, TcMscS IN TRYPANOSOMA CRUZI
Creators: name: Kannan, Akshara
Publisher: name: Zenodo
Year: 2022
Subjects: Trypanosoma cruzi
mechanosensitive channel TcMscS
signaling pathways
diacylglycerol kinase
kinesin
cytokinesis

description: Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. With no successful treatment options, there is an urgent need to find new therapeutic approaches for this disease. The protozoan Trypanosoma cruzi faces environmental challenges to maintain homeostasis and complete its lifecycle. A bacterial-like mechanosensitive channel TcMscS, found in the parasites, plays a vital role in growth, infectivity, differentiation, and osmoregulation. However, the information available on the signaling pathways responsible for these phenotypes is scarce. This study attempted to identify the signaling pathways downstream of TcMscS activation. Based on RNA-Sequence analysis of TcMscS KO mutants, diacylglycerol kinase (DAGK) and kinesin were selected as candidate genes for this study, and their role was investigated. Localization studies revealed the possible localization of kinesin near the contractile vacuole and the flagellar pocket. Using CRISPR/Cas9 methods, the expression level of the candidate genes was manipulated. The candidate gene KO mutants showed significant growth defects and cytokinesis defects. The kinesin KO mutants showed abnormal motility and a bent flagellum. Overall, this study reveals the possible role of diacylglycerol kinase and kinesin in parasite growth and cell division.
E01206: Fragment of an altar with a partially preserved Greek inscription, mentioning *Paul the Apostle (S00008), possibly patron of the church. Found at Pythagorio (Samos, the Aegean Islands). Probably mid-6th c.
Creators: name: Pnowakowski
Publisher: name: University of Oxford
Year: 2016
Subjects: History

description: [--- τ]οῦ ἐνδόξου ἀπ(οστόλο)υ Παύλου (christogram)

1. [--- τ]οῦ Hallof, [- - -]Σ Steckner SEG

"[- - - of[ the glorious Apostle Paul. (christogram)"

Text: IG XII 6,2, no. 941.
Additional file 1 of A meta-analysis and trial sequential analysis comparing nonoperative versus operative management for uncomplicated appendicitis: a focus on randomized controlled trials
Creators: name: Brucchi, Francesco
name: Bracchetti, Greta
name: Fugazzola, Paola
name: Viganò, Jacopo
name: Filisetti, Claudia
name: Ansaloni, Luca
name: Dal Mas, Francesca
name: Cobianchi, Lorenzo
name: Danelli, Piergiorgio
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Science Policy

description: Additional file 1. Supplementary Figures 1–6.
Strategy for Youth Empowerment and Entrepreneurship: An assessment of WOW Outreach, Flint, MI
Creators: name: Bingham, Psalm
name: Gasteyer, Stephen
Publisher: name: unknown
Year: 2020
Subjects: subject: Michigan--Flint
subject: Economic development
subject: Youth
subject: Entrepreneurship

description: This project will develop an outline for youth entrepreneurship in the North Side of Flint, Michigan with the help of WOW Outreach of Flint. The report will further WOW Outreach's goals of reducing violence through positive opportunities and increasing economic opportunities through the use of Flint's Community Capitals Framework. Through this research WOW Outreach will be able to address critical development needs, specifically focusing on youth empowerment, and allow youth entrepreneurship to grow and prosper in the North Side of Flint.
La protección de la obligatoriedad del precedente judicial a través de la acción de tutela en contra de providencias judiciales
Creators: name: García Loaiza, Antonio Luis
Publisher: name: Universidad Externado de Colombia
Year: 2024
Subjects: subject: Tutela - Aspectos constitucionales - Colombia
subject: Derechos humanos - Protección - Colombia
subject: Administración de justicia - Aspectos constitucionales - Colombia
subject: Precedente
subject: Tutela
subject: Causales
subject: Obligatoriedad

description: La investigación analiza cómo la Corte Constitucional ha desarrollado el concepto de precedente judicial en Colombia y por qué es fundamental para proteger los derechos y asegurar la coherencia en el ordenamiento jurídico. Se destaca la necesidad de tener una definición clara de lo que significa un precedente, para poder aplicar correctamente las causales que justifican su obligatoriedad en la acción de tutela contra providencias judiciales. Esta acción es importante para asegurar que se sigan las decisiones anteriores en casos similares. Sin embargo, la falta de claridad en la definición de precedente ha generado confusión y dificultades en su aplicación, afectando la estabilidad y previsibilidad del derecho. Además, se enfatiza que aplicar correctamente estas causales es importante para evitar la violación de derechos fundamentales. Para solucionar estos problemas, se sugiere la creación de un marco teórico más claro y la implementación de reformas legislativas que refuercen la obligatoriedad del precedente en todas las instancias judiciales. Esto ayudaría a asegurar una justicia más coherente y accesible para todos. En resumen, el estudio demuestra la importancia de definir claramente lo que es un precedente judicial para mejorar la administración de justicia en Colombia.
description: The research examines how the Constitutional Court has developed the concept of judicial precedent in Colombia and why it is crucial for safeguarding rights and maintaining coherence within the legal system. It highlights the necessity of a clear definition of what constitutes a precedent in order to properly apply the grounds that justify its binding nature in tutela actions against judicial rulings. This action is essential to ensure that prior decisions in similar cases are followed consistently. However, the lack of clarity in defining precedent has led to confusion and challenges in its application, thereby undermining the stability and predictability of the law. Additionally, it is emphasized that correctly applying these grounds is vital to prevent violations of fundamental rights. To address these issues, the study suggests creating a clearer theoretical framework and implementing legislative reforms to reinforce the binding nature of precedent across all judicial levels. This approach would help ensure a more coherent and accessible justice system for all. Ultimately, the study demonstrates the importance of clearly defining what constitutes judicial precedent in order to enhance the administration of justice in Colombia.
Exponentially weighted averaging of varying-coefficient partially linear models
Creators: name: Cui, Bosen
name: Li, Jialiang
name: Nott, David
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Biophysics
Medicine
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified

description: Despite the increasing attention given to frequentist model averaging methods, few studies address the theoretical aspects of semiparametric model averaging. In this paper, we introduce an exponentially weighted model averaging (EWA) method for the varying-coefficient partially linear model (VCPLM). Our weighting method is straightforward to implement and has a natural Bayesian interpretation. We establish oracle inequalities for the finite sample error bound of the empirical estimators and thoroughly investigate the asymptotic optimality of the proposed weighting criterion, along with other statistical properties. Some numerical studies are provided which support the theoretical findings.
sj-pdf-1-cre-10.1177_0269215520975127 – Supplemental material for The impact of injury: The experiences of children and families after a child’s traumatic injury
Creators: name: Jones, Samantha
name: Tyson, Sarah
name: Yorke, Janelle
name: Davis, Naomi
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 110314 Orthopaedics
subject: 110604 Sports Medicine
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-1-cre-10.1177_0269215520975127 for The impact of injury: The experiences of children and families after a child’s traumatic injury by Samantha Jones, Sarah Tyson, Janelle Yorke and Naomi Davis in Clinical Rehabilitation
Penalized variable selection with broken adaptive ridge regression for semi-competing risks data
Creators: name: Mahmoudi, Fatemeh
name: Lu, Xuewen
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Cancer

description: Semi-competing risks data arise when both non-terminal and terminal events are considered in an illness-death model. Such data with multiple events of interest are frequently encountered in medical research and clinical trials. Unlike some recent works on penalised variable selection that deal with the competing risks separately without incorporating possible correlation between them, we perform variable selection in the illness-death model using shared frailty. We propose a broken adaptive ridge (BAR) penalty to encourage sparsity and perform variable selection in an event-specific manner so that the potential risk factors can be selected and their effects can be estimated simultaneously, corresponding to each event in the study. The oracle property of the proposed BAR procedure is established, and its performance is evaluated and compared with other commonly used methods by simulation studies. The proposed method is then applied to the real-life data arising from a colon cancer study.
E01208: Greek inscription on a sarcophagus with an epitaph, probably for a bishop (unnamed) who preached on the doctrine of the Holy Trinity, considered by the locals as a successful intercessor. Found near Laphiona (Lesbos, the Aegean Islands). Probably 4th-5th c.
Creators: name: Pnowakowski
Publisher: name: University of Oxford
Year: 2016
Subjects: History

description: + ὁ τῆς Τριάδος κῆρυξ
 καὶ τῆς π̣αρθ̣ε̣νίας φύλαξ
Α καὶ τοῦ Χ(ριστο)ῦ φίλος Ω
 ἐνθάδε κατάκιται
 ὑπὲρ ἡμῶν εὐχόμενος

"Α + The herald of the Trinity and the guardian of virginity and a friend of Christ lies here, praying for us. Ω"

Text: Charitonidis 1968, 54.
sj-pdf-2-tah-10.1177_2040620720977039 – Supplemental material for Adverse events in second- and third-line treatments for acute and chronic graft-versus-host disease: systematic review
Creators: name: Velickovic, Vladica M.
name: McIlwaine, Emily
name: Rongrong Zhang
name: Spelman, Tim
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: Cardiology
subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: FOS: Clinical medicine
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified

description: Supplemental material, sj-pdf-2-tah-10.1177_2040620720977039 for Adverse events in second- and third-line treatments for acute and chronic graft-versus-host disease: systematic review by Vladica M. Velickovic, Emily McIlwaine, Rongrong Zhang and Tim Spelman in Therapeutic Advances in Hematology
DEVELOPMENT OF AN EARLY-MATURING COTTON VARIETY SUITABLE FOR CULTIVATION IN THE CONDITIONS OF THE REPUBLIC OF KARAKALPAKSTAN BASED ON AMPHIDIPLOID G. THURBERI TOD. AND G. RAIMONDII ULBR
Creators: name: Turimbetov, Muratbay
Publisher: name: Zenodo
Year: 2024

description: This study focuses on the development of an early-maturing cotton variety adapted to the environmental conditions of the Republic of Karakalpakstan. Utilizing amphidiploid hybrids of Gossypium thurberi Tod. and Gossypium raimondii Ulbr., the research aims to create a variety that meets the local agricultural requirements, including resistance to abiotic stress and optimized yield in the region’s unique climate. Field trials and genetic analysis were conducted to identify key traits such as maturity, fiber quality, and stress tolerance. The resulting variety demonstrates potential for enhancing cotton production in arid and semi-arid regions of Karakalpakstan.
E01210: On 6 September 503, the citizens of Edessa bring in the relics of martyrs from the shrines outside the city while preparing for the city to be besieged by the Persian king Kavadh I (r. 488-531). Record in the Syriac Chronicle of Pseudo-Joshua the Stylite (6th c.).
Creators: name: Sminov
Publisher: name: University of Oxford
Year: 2016
Subjects: History

description: Chronicle of Pseudo-Joshua the Stylite 59

ܡܖ̈ܚܐ ܕܝܢ ܐܝܠܝܢ ܕܐܝܬ ܗܘܐ ܒܚܝܠܘ̈ܬܗ܇ ܡܬܟܪܟܝܢ ܒܐܬܪܐ ܘܡܚܪܒܝܢ ܠܗ. ܒܝܘܡ ܫ̈ܬܐ ܒܐܪܚ ܐܠܘܠ܇ ܥܩܪܘ ܐܘܪܗܝܐ ܟܠܗܝܢ ܕܝܖ̈ܬܐ ܘܦܘ̈ܬܘܐ ܕܩܪܝܒܝܢ ܗܘܘ ܨܝܕ ܫܘܪܐ. ܘܐܘܩܕ ܠܟܦܪ ܨܠܡ ܩܪܝܬܐ ܕܗ̣ܝ ܢܓܒܬ. ܘܓܡܘ ܟܠܗܘܢ ܣܝ̈ܓܐ ܕܓ̈ܢܐ ܘܠܦܖ̈ܕܝܣܐ ܕܠܕܝܪܝܢ ܗܘܘ. ܘܦܣܩܘ ܐܝ̈ܠܢܐ ܕܒܓܘܗܘܢ. ܘܐܥܠܘ ܓܖ̈ܡܐ ܕܟܠܗܘܢ ܣܗ̈ܕܐ ܕܐܝܬ ܗܘܐ ܚܕܖ̈ܝ ܡܕܝܢܬܐ.

'On the sixth of September, the Edessenes flattened all the monasteries and inns which were situated adjacent to the wall, and set fire to Kephar Selem, the village which is (also known as) Negbath. They cut down all the hedges of the surrounding parks and gardens, and felled the trees in them, and they brought in the bones of all the martyrs which were (in the churches) surrounding the city.'

Ed. Chabot 1927-1949, v. 1, p. 286; trans. by Trombley and Watt 2000, p. 75.
Additional file 1 of Microaerobic insights into production of polyhydroxyalkanoates containing 3-hydroxyhexanoate via native reverse β-oxidation from glucose in Ralstonia eutropha H16
Creators: name: Huong, Kai-Hee
name: Orita, Izumi
name: Fukui, Toshiaki
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology

description: Additional file 1: Table S1. Progress on P(3HB-co-3HHx) production from structurally unrelated carbon sources by recombinant bacteria. Table S2. Genes involved in this study. Table S3. Sequences of primers used in this study. Table S4. Effect of shaking condition on P(3HB-co-3HHx) biosynthesis by parent NSDG-GG and the phaB-deleted mutants. Table S5. Time profile of PHA accumulation in R. eutropha strains under aerobic and microaerobic cultivation. Table S6. Effects of nitrogen and oxygen limitation on PHA production by R. eutropha ΔB1 under microaerobic condition. Table S7. Effects of gene disruption of endogenous genes potentially related to 3HHx incorporation into PHAs in R. eutropha ΔB1-based strains under microaerobic condition. Table S8. Effects of introduction of Ccr-Emd along with PhaJ4a/PhaJAc on P(3HB-co-3HHx) biosynthesis by R. eutropha NSDG-GG and the phaB-deleted strains under aerobic and microaerobic conditions.
The improved correlation coefficient of Chatterjee
Creators: name: Xia, Liqi
name: Cao, Ruiyuan
name: Du, Jiang
name: Chen, Xiuping
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Space Science
Molecular Biology
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Mathematical Sciences not elsewhere classified
Science Policy

description: Chatterjee's new coefficient proposed by Chatterjee [2021, ‘A New Coefficient of Correlation’, Journal of the American Statistical Association, 116(536), 2009–2022.] is used to measure the degree of dependence between two scalars by rank correlation. However, the independence test based on Chatterjee's rank correlation may lose power since it only considers the distance between the nearest neighbours and ignores the other neighbours. In this paper, we propose an improvement to Chatterjee's new coefficient by incorporating the inverse distance-weighting, and further obtain the asymptotic normality of the improved coefficient and the Berry–Esseen bound under the null hypothesis. The proposed method is evaluated on the simulated as well as the real data on Yeast Gene Expression. The results show that the proposed method is superior to Chatterjee's new coefficient under various alternative hypotheses.
Makerspace Prototype Exploration for Local Micro-Business Incubator
Creators: name: Casper, Lisa
name: Davis, Melissa
Publisher: name: Humanities Commons
Year: 2021
Subjects: subject: Economic development
subject: Entrepreneurship
subject: Economics
subject: Sustainable development

description: This project is designed to hedge against further decline in our economy by creating the preconditions to help graduating high school seniors to create economic opportunities, innovate their way forward, connect with innovation and entrepreneurship resources and lead by example. Scope & Community Engagement Michigan Technological University's innovation and entrepreneurship resource hub, Husky Innovate, was approached by New Power Tour, Inc.(NPT-501c3), to build an economic support mechanism for our economically-challenged area of the Western U.P. Our partnership takes the form of a Houghton High School National Honor Society (HHSNHS) student-led pilot project that will familiarize students with the steps involved in building a business by participating in experiential learning exercises at each phase of an innovation. During this pilot project, students will engage in activities to understand opportunity recognition, prototyping, product-market-fit, brand definition, commercialization and sales. While students gain knowledge and experience as innovators, they will connect with resources within our local innovation and entrepreneurship ecosystem and strengthen community networks while simultaneously highlighting gaps to be addressed.
E01211: In 503, after the unsuccessful siege of the city of Edessa (Mesopotamia), the troops of the Persian king Kavadh I (r. 488-531) destroy the martyria-churches of *Sergios (soldier and martyr of Rusafa, S00023) and of the 'Confessors' (*Shmona and Gurya, *Habbib, martyrs of Edessa, ob. 309-312) located outside the city. Record in the Syriac Chronicle of Pseudo-Joshua the Stylite (6th c.).
Creators: name: Sminov
Publisher: name: University of Oxford
Year: 2016
Subjects: History

description: Chronicle of Pseudo-Joshua the Stylite 62

ܘܡܢ ܕܚܙܘ ܕܠܐ ܠܡܕܝܢܬܐ ܡܫܟܚܝܢ ܠܡܥܠ܇ ܘܠܐ ܠܐܢܫ̈ܐ ܥܖ̈ܛܠܝܐ ܕܚܠܝܛܝܢ ܒܝܢܬܗܘܢ ܠܡܗܪܘ܇ ܐܪܡܝܘ ܢܘܪܐ ܒܝܬ ܡܪܝ ܣܪܓܝܤ ܘܒܝܬ ܡܘܕ̈ܝܢܐ. ܘܒܟܠܗܝܢ ܕܝܖ̈ܬܐ ܕܐܫܬܚܪ. ܘܒܥܕܬܐ ܕܢܓܒܬ. ܠܗܕܐ ܓܝܪ ܫܒܩܘܗ̇ ܗܘܘ ܒܢ̈ܝ ܡܕܝܢܬܐ.

'When they saw that they could neither get into the city nor injure the unarmed men caught up in their midst, they set alight the church of Mar Sergius, the church of the Confessors, and all the monasteries which (the Edessenes) had left intact, as well as the church in Negbath, for the citizens had also left it.'

Ed. Chabot 1927-1949, v. 1, p. 291; trans. by Trombley and Watt 2000, p. 81.
sj-pdf-1-pih-10.1177_0954411920976223 – Supplemental material for A detailed finite element model of a mid-sized male for the investigation of traffic pedestrian accidents
Creators: name: Grindle, Daniel
name: Wansoo Pak
name: Guleyupoglu, Berkan
name: Bharath Koya
name: F Scott Gayzik
name: Song, Eric
name: Untaroiu, Costin
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110323 Surgery
subject: FOS: Clinical medicine
subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies

description: Supplemental material, sj-pdf-1-pih-10.1177_0954411920976223 for A detailed finite element model of a mid-sized male for the investigation of traffic pedestrian accidents by Daniel Grindle, Wansoo Pak, Berkan Guleyupoglu, Bharath Koya, F Scott Gayzik, Eric Song and Costin Untaroiu in Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine
Makerspace Prototype Exploration for Local Micro-Business Incubator
Creators: name: Casper, Lisa
name: Davis, Melissa
Publisher: name: unknown
Year: 2021
Subjects: subject: Economics
subject: Sustainable development
subject: Economic development
subject: Entrepreneurship

description: This project is designed to hedge against further decline in our economy by creating the preconditions to help graduating high school seniors to create economic opportunities, innovate their way forward, connect with innovation and entrepreneurship resources and lead by example. Scope & Community Engagement Michigan Technological University's innovation and entrepreneurship resource hub, Husky Innovate, was approached by New Power Tour, Inc.(NPT-501c3), to build an economic support mechanism for our economically-challenged area of the Western U.P. Our partnership takes the form of a Houghton High School National Honor Society (HHSNHS) student-led pilot project that will familiarize students with the steps involved in building a business by participating in experiential learning exercises at each phase of an innovation. During this pilot project, students will engage in activities to understand opportunity recognition, prototyping, product-market-fit, brand definition, commercialization and sales. While students gain knowledge and experience as innovators, they will connect with resources within our local innovation and entrepreneurship ecosystem and strengthen community networks while simultaneously highlighting gaps to be addressed.
Societal Transformations, Politics, Economics, Education, Development, Environment and the State of the World
Creators: name: Pilon, André Francisco
Publisher: name: Humanities Commons
Year: 2023
Subjects: subject: Education and state
subject: World politics
subject: Environmental economics
subject: Environmental sustainability
subject: Ethics
subject: Biotic communities

description: An ecosystem theoretical and practical framework is posited for the evaluation and planning of advocacy, communication, public policies, research and teaching programmers, intertwining four dimensions of being-in-the-world (intimate, interactive, social and biophysical), as they combine, as donors and recipients, to induce the events (deficits/assets), cope with consequences (desired/undesired) and contribute for change (potential outputs). Earth’s regeneration and mankind’s regeneration, as faces of the same coin, are addressed simultaneously, in space and time, for their mutual support. Goals and new paths to reach them contemplate a set of values, norms and policies that prioritizes socio-ecological objectives, human well-being, natural and built environments, the aesthetic, ethical and cultural meaning of the existence.
Additional file 3 of IKT Guiding Principles: demonstration of diffusion and dissemination in partnership
Creators: name: Shwed, Alanna
name: Hoekstra, Femke
name: Bhati, DivyaKanwar
name: Athanasopoulos, Peter
name: Chernesky, John
name: Martin Ginis, Kathleen
name: McBride, Christopher B.
name: Mortenson, W. Ben
name: Sibley, Kathryn M.
name: Sweet, Shane N.
name: Gainforth, Heather L.
Publisher: name: figshare
Year: 2024
Subjects: Biotechnology
Cancer
Science Policy

description: Additional file 3. IKT Guiding Principles and Enacted Strategies
Espacios de formación y comercialización agroecología.
Creators: name: Cruz, Bianca
Publisher: name: Humanities Commons
Year: 2023

description: Los espacios de comercialización agroecológica se han expandido en el país, debido a la importancia que los productores y consumidores le están dando al origen y la forma de producción de los alimentos. Sin embargo, poco se ha estudiado sobre la interacción entre consumidores y productores en las ferias, y cómo éstas se convierten en espacios de aprendizaje y comercialización para ambos actores
E01212: Fragmentary Greek inscription with an invocation of *Polycarp/Polykarpos (martyr of Smyrna, S00004). Found at Mytilene (Lesbos, the Aegean Islands). Probably late antique or middle Byzantine.
Creators: name: Pnowakowski
Publisher: name: University of Oxford
Year: 2016
Subjects: History

description: [- - - ἅγι]ε Πολύκαρπε τῶν κλῆ[ρον σου - - -] τίρησον αὐτό[ν]

1. perhaps αὐτõ[ν]

'[- - - Saint] Polykarpos, [help (?) your] clergy (?) [- - -] guard him!'

Text: Charitonidis 1968, 21.
Avoiding the surrogate paradox: an empirical framework for assessing assumptions
Creators: name: Hsiao, Emily
name: Tian, Lu
name: Parast, Layla
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Medicine
Pharmacology
Mathematical Sciences not elsewhere classified
Science Policy

description: The use of surrogate markers to replace a primary outcome in clinical trials has the potential to allow earlier decisions about the effectiveness of a treatment when a direct measurement of the primary outcome is difficult to obtain. However, the surrogate paradox, which occurs when a treatment has a positive effect on the surrogate marker but a negative effect on the primary outcome, may lead researchers to make incorrect conclusions about the treatment benefit. In this paper, we propose a formal nonparametric framework to empirically examine and test assumptions that ensure avoidance of the surrogate paradox. For each assumption, we propose a nonparametric hypothesis test, formally derive the properties of the test, and analyze its performance in finite samples in a variety of simulation settings. We apply our proposed testing framework to data from the the Diabetes Prevention Program clinical trial.
Espacios de formación y comercialización agroecología.
Creators: name: Cruz, Bianca
Publisher: name: unknown
Year: 2023

description: Los espacios de comercialización agroecológica se han expandido en el país, debido a la importancia que los productores
y consumidores le están dando al origen y la forma de producción de los alimentos. Sin embargo, poco se ha estudiado sobre la interacción entre consumidores y productores en las ferias, y cómo éstas se convierten en espacios
de aprendizaje y comercialización para ambos actores
Additional file 2 of IKT Guiding Principles: demonstration of diffusion and dissemination in partnership
Creators: name: Shwed, Alanna
name: Hoekstra, Femke
name: Bhati, DivyaKanwar
name: Athanasopoulos, Peter
name: Chernesky, John
name: Martin Ginis, Kathleen
name: McBride, Christopher B.
name: Mortenson, W. Ben
name: Sibley, Kathryn M.
name: Sweet, Shane N.
name: Gainforth, Heather L.
Publisher: name: figshare
Year: 2024
Subjects: Biotechnology
Cancer
Science Policy

description: Additional file 2. IKT Guiding Principles Partnership Governance Structure
sj-pdf-1-jop-10.1177_0269881120965908 – Supplemental material for Presynaptic vesicular accumulation is required for antipsychotic efficacy in psychotic-like rats
Creators: name: Uzuneser, Taygun C
name: Eva-Maria Weiss
name: Dahlmanns, Jana
name: Kalinichenko, Liubov S
name: Amato, Davide
name: Kornhuber, Johannes
name: Alzheimer, Christian
name: Hellmann, Jan
name: Kaindl, Jonas
name: Hübner, Harald
name: Löber, Stefan
name: Gmeiner, Peter
name: Grömer, Teja W
name: Müller, Christian P
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)

description: Supplemental material, sj-pdf-1-jop-10.1177_0269881120965908 for Presynaptic vesicular accumulation is required for antipsychotic efficacy in psychotic-like rats by Taygun C Uzuneser, Eva-Maria Weiss, Jana Dahlmanns, Liubov S Kalinichenko, Davide Amato, Johannes Kornhuber, Christian Alzheimer, Jan Hellmann, Jonas Kaindl, Harald Hübner, Stefan Löber, Peter Gmeiner, Teja W Grömer and Christian P Müller in Journal of Psychopharmacology
E01213: Greek inscription on a boundary stone of a church dedicated to *Michael (the Archangel, S00181). Found on Lesbos (the Aegean Islands), probably close to Mytilene. Probably late antique.
Creators: name: Pnowakowski
Publisher: name: University of Oxford
Year: 2016
Subjects: History

description: ὅροι τοῦ ἁγ[ίου]
ἀρχαγ[γέλου]
Μιχ[αήλ]

'Boundaries of the holy Archangel Michael.'

Text: Charitonidis 1968, 20.
Implementing a gameful formative assesment (GFA)-based model into secondary school classroom instruction to facilitate learner- generated feedback and promote autonomous and heutagogic learning
Creators: name: Amfo-Brobbey, Mamet
Publisher: name: Anglia Ruskin Research Online (ARRO)
Year: 2025

description: Gameful formative assessments (GFAs) are instructional tools that use game components to assess and provide quick feedback on learner competencies with the intention of promoting learning. This research used three iterative Pedagogical Action Research (PedAR) cycles to introduce a GFA based model and refine classroom assessment routines around its use to establish a heutagogical culture in which students became more self-determined and autonomous. This was necessary to help prepare students for success in the twenty-first century. During the first cycle, implementing the GFA-based model resulted in a significant change in assessment routines in the research classrooms and improved learner attitudes towards formative assessment. The strategies from the previous cycle were refined and adjusted in the second cycle to achieve a discernible shift in practice towards pedagogical partnerships in formative evaluation, as well as an understanding that ongoing teacher training and support were required to use GFA tools effectively. The third cycle built on previous achievements to foster a culture of self-directed learning through formative evaluations. In this culture, teachers guided and supported self-sufficient, responsible, and motivated students.The study discovered that sustained autonomous feedback generation increased learner engagement in formative evaluation and improved learners' ability to self-evaluate and devise appropriate strategies to advance their learning. Over time, these strategies promoted agentic engagement. The study found that staff skills and beliefs had a significant impact on student attitudes and achievement. The findings also showed that learner-centric approaches can transform instructional practices and equip students with critical lifelong learning skills when combined with appropriate tools and strategies. The study serves as a practical case study for studies into instructional innovation, gameful learning, involving learners in decision-making, and the factors that promote learner autonomy.
E01214: Greek inscription with an invocation of the God of *George (soldier and martyr, S00259), asked to help 'those who remember the grace of George'. Found near Mytilene (Lesbos, the Aegean Islands). Probably 6th c. or later.
Creators: name: Pnowakowski
Publisher: name: University of Oxford
Year: 2016
Subjects: History

description: + ὁ θ(εὸ)ς τοῦ [ἁ]γίου [Γ]ε[ω]ργί-
ου δὼς ἄφεσιν ἁ[μαρ]-
[τ]ιῶν τῦς [μ]νημωνε-
ύουσιν τὶν χάριν τ[ο]ῦ [ἁ]γ[ί]-
ου Γεωργίου, καὶ ἀφέσε-
ως ἁμαρτιῶν Σταυρ[α]-
κίο. γένυτο Κ(ύρι)ε
 ἀμήν

'+ O, God of Saint George, give the remission of sins to those who remember the grace of Saint George, and the remission of sins to Staurakios. May it be so, Lord. Amen.'

Text: IGC, no. 157.
A novel framework for online supervised learning with feature selection
Creators: name: Sun, Lizhe
name: Wang, Mingyuan
name: Zhu, Siquan
name: Barbu, Adrian
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: Current online learning methods suffer issues such as lower convergence rates and limited capability to select important features compared to their offline counterparts. In this paper, a novel framework for online learning based on running averages is proposed. Many popular offline regularised methods such as Lasso, Elastic Net, Minimax Concave Penalty (MCP), and Feature Selection with Annealing (FSA) have their online versions introduced in this framework. The equivalence between the proposed online methods and their offline counterparts is proved, and then novel theoretical true support recovery and convergence guarantees are provided for some of the methods in this framework. Numerical experiments indicate that the proposed methods enjoy high true support recovery accuracy and a faster convergence rate compared with conventional online and offline algorithms. Finally, applications to large datasets are presented, where again the proposed framework shows competitive results compared to popular online and offline algorithms.
Additional file 1 of Non-overdose acute care hospitalizations for opioid use disorder among commercially-insured adults: a retrospective cohort study
Creators: name: Raman, Sudha R.
name: Ford, Cassie B.
name: Hammill, Bradley G.
name: Clark, Amy G.
name: Clifton, Dana C.
name: Jackson, George L.
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Pharmacology
Biotechnology
Cancer
Science Policy
Mental Health
Hematology
Computational Biology

description: Additional file 1: Appendix Table 1. OUD code list. Appendix Table 2. OUD in remission code list. Appendix Table 3. Opioid overdose, poisoning, or adverse events code list. Appendix Table 4. Included OUD medications (as indicated in outpatient dispensed prescriptions. Appendix Table 5. Percent of hospitalizations with opioid overdose, by study year. Appendix Table 6. Most frequent primary diagnoses for Secondary-OUD* hospitalizations. Appendix Table 7. Discharge status codes used to indicate discharge to an outpatient setting.
Creation and implementation of variant curation workflow for the ClinGen inborn errors in metabolism working group: phenylalanine hydroxylase deficiency
Creators: name: Zastrow, Diane
name: Baudet, Heather
name: Si, Cindy
name: Weaver, Meredith
name: Lager, Angela
name: Lee, Kristy
name: Shen, Wei
name: Thomas, Amanda
name: Berg, Jonathan
name: Dobrowolski, Steven
name: Eilbeck, Karen
name: Enns, Gregory
name: Feigenbaum, Annette
name: Lichter-Konecki, Uta
name: Lyon, Elaine
name: Pasquali, Marzia
name: Craigen, William
name: Mao, Rong
name: Steiner, Robert
Publisher: name: F1000Research
Year: 2017

description: The ClinGen Inborn Errors in Metabolism Working Group was tasked with creating a comprehensive, standardized knowledge base of genes and variants for metabolic diseases. Phenylalanine hydroxylase (PAH) deficiency was chosen for development of the Working Group’s variant curation protocol. Before curation began, the work group members modified the ACMG guidelines for variant interpretation to be specific for PAH deficiency. Notable modifications to the ACMG criteria include: diagnostic laboratory assay of PAH activity as evidence for in vivo studies; addition of 3 criteria (PS5, PM7, PP6) that use abnormal analytes (blood PHE) and metabolic and/or molecular assessment of disorders with similar analytes. To aid in this process, a password protected web database was created which allows for editing and links to pdf files of the references used for each variant. Embedded in the web site are links to web sites used for curation (e.g. population databases, computational tools, PubMed), our Modified ACMG criteria, and ACMG Classification Guidelines. As the biocuration workforce grew, a variant curation protocol and workflow was created for use in training and standardization. This protocol has 5 main steps: (1) transcribe gene specific databases (BioPKU and PAHdb); (2) determine frequency of variant in large population studies, parsed by race; (3) determine if computational tools and conservation predict an effect on protein structure or splicing; (4) check clinical significance and phenotype in variant databases; (5) search for primary literature. This protocol includes PAH-specific search terms and nomenclature to use for each web site/database. Five curators subsequently tested the variant curation protocol and workflow. Creation of the modified ACMG guidelines, protected PAH curation web database, and Metabolic Workgroup Variant Curation protocol enabled the standardization of PAH variant curation.
ESPACIOS DE FORMACIÓN Y COMERCIALIZACIÓN AGROECOLÓGICA.
Creators: name: SILVANA PILLAJO ANDRANGO, NATALY
Publisher: name: Humanities Commons
Year: 2023

description: En el siguiente articulo podemos ver  una encuesta realizada  en el consumo  y relación, entre los productores y consumidores  de la feria agroecológica en la UCE.se podría decir que por medio de unas encuestas realizadas a nivel nacional también pudimos ver que se encontraron diferentes resultados  entre ellos están los  puntos de comercialización se realizan mayoritariamente  en la sierra  que tiene un 154 comerciantes ,seguida de la costa con un 53  y también el oriente con un  18  y galápagos con un tres.
ESPACIOS DE FORMACIÓN Y COMERCIALIZACIÓN AGROECOLÓGICA.
Creators: name: SILVANA PILLAJO ANDRANGO, NATALY
Publisher: name: unknown
Year: 2023

description: En el siguiente articulo podemos ver una encuesta realizada en el consumo y relación, entre los productores y consumidores de la feria agroecológica en la UCE.se podría decir que por medio de unas encuestas realizadas a nivel nacional también pudimos ver que se encontraron diferentes resultados entre ellos están los puntos de comercialización se realizan mayoritariamente en la sierra que tiene un 154 comerciantes ,seguida de la costa con un 53 y también el oriente con un 18 y galápagos con un tres.
Statistical inference for innovation distribution in ARMA and multi-step-ahead prediction via empirical process
Creators: name: Zhong, Chen
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Plant Biology

description: The kernel distribution estimator (KDE) is proposed based on residuals of the innovation distribution in the autoregressive moving-average (ARMA) time series. The deviation between KDE and the innovation distribution function is shown to converge to the Brownian bridge, leading to the construction of a Kolmogorov–Smirnov smooth simultaneous confidence band for the innovation distribution function. Additionally, an empirical cumulative distribution function (CDF) based on prediction residuals is introduced for the multi-step-ahead prediction error distribution function. This empirical process weakly converges to a Gaussian process with a specific covariance function. Furthermore, a quantile estimator is derived from the empirical CDF of prediction residuals, and multi-step-ahead prediction intervals (PIs) for future observations are established using these estimated quantiles. The PIs achieve the nominal prediction level asymptotically for the finite variance ARMA model. Simulation studies and analysis of crude oil price data confirm the validity of the asymptotic theory.
Curing National Amnesia:The Next Steps Needed for Britain andSouth Africa to Create a Fulfilling PublicMemory Culture
Creators: name: Mofor, Yannick
Publisher: name: Stanford Digital Repository
Year: 2024
Subjects: College students' writings, South Africa, Apartheid, public protest, post-colonial memory

description: This essay won or received an honorable mention for The Boothe Prize for excellence in first-year writing. The Boothe Prize recognizes and rewards outstanding expository and argumentative writing by undergraduate students in first-year classes that satisfy the WR 1 requirement. In each award-winning essay, student writers demonstrate clarity of argument, excellent integration of research-based evidence, and compelling prose style. In his essay on post-colonial public memory in South Africa and Britain, Yannick Mofor offers an approach to resolving public protest, suggesting that “the foundation of ... change must be rooted in education.” Mofor draws on careful research that considers the perspectives of people on all sides of the issues--ranging from protesting students in South Africa to British politicians who are not prepared to dismantle their colonial heritage—to offer solutions grounded in the fundamental principles of listening to and respecting all voices.
Additional file 1 of Clinical, biochemical, and genetic spectrum of MADD in a South African cohort: an ICGNMD study
Creators: name: Bisschoff, Michelle
name: Smuts, Izelle
name: Dercksen, Marli
name: Schoonen, Maryke
name: Vorster, Barend C.
name: van der Watt, George
name: Spencer, Careni
name: Naidu, Kireshnee
name: Henning, Franclo
name: Meldau, Surita
name: McFarland, Robert
name: Taylor, Robert W.
name: Patel, Krutik
name: Fassad, Mahmoud R.
name: Vandrovcova, Jana
name: Wanders, Ronald J. A.
name: van der Westhuizen, Francois H.
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1. Additional Clinical Information.
Supporting info item, PER_807_sm_Supporting_Information - General Belief in A Just World and Resilience: Evidence from A Collectivistic Culture
Creators: name: Wu, Michael Shengtao
name: Yan, Xiaodan
name: Zhou, Chan
name: Chen, Yiwen
name: Li, Juan
name: Zhu, Zhuohong
name: Shen, Xiangqin
name: Han, Buxin
Publisher: name: SAGE Journals
Year: 2020
Subjects: Psychology not elsewhere classified

description: Supporting info item, PER_807_sm_Supporting_Information for General Belief in A Just World and Resilience: Evidence from A Collectivistic Culture by Wu Michael Shengtao, Yan Xiaodan, Zhou Chan, Chen Yiwen, Li Juan, Zhu Zhuohong, Shen Xiangqin and Han Buxin in European Journal of Personality
Espacios De Formación Y Comercialización Agroecológica: Lecciones Aprendidas En La Universidad Central del Ecuador
Creators: name: Fuerez, Lizbeth
Publisher: name: unknown
Year: 2023

description: Los espacios de comercialización en área agroecológica se expandieron por todo el país, debido a la gran importancia que le están dando al historial del origen y la producción de los productos alimentarios por lo tanto se ha visto que hay poco estudio o informes sobre la interacción entre consumidores y productores, por lo tanto, se analizo las ferias que promociona la Universidad Central del Ecuador ya que en el país es una de las pocas unidades educativas que impulsan la fomentación de las ferias en el país.
Lo cual se empleó diversas técnicas de recolección de datos tales como entrevistas, encuestas y todo relacionado a lo agroecológico (revisión de bibliografías, mercados, circuitos cortos y redes comerciales).La primera encuesta se realizó a los consumidores frecuentes en los 6 meses de funcionamiento y la segunda se realizó a los consumidores después de un año estas encuestas se realizaron para corroborar las preferencias en el consumo de productos.
Los principales consumidores son jóvenes y mujeres, estos consumidores perciben a los productos agroecológicos como más sanos y naturales (productos orgánicos) lo cual influye en la preferencia del consumo (compra).
E01215: During the year 504/5, the eunuch Urbicius makes a donation for a martyrium-church dedicated to *Mary (Mother of Christ, S00033) to be built in Edessa (Mesopotamia). During the same year the city's governor Eulogius carries out a redistribution of the oil assigned for the urban martyr shrines. Record in the Syriac Chronicle of Pseudo-Joshua the Stylite (6th c.).
Creators: name: Sminov
Publisher: name: University of Oxford
Year: 2016
Subjects: History

description: Chronicle of Pseudo-Joshua the Stylite 87

ܐܦ ܠܐܦܝܣܩܘܦܐ ܝܗܒ ܠܗ ܡܠܟܐ ܥܣܖ̈ܝܢ ܠܝܛܖ̈ܝܢ ܠܢܦ̈ܩܬܐ ܘܠܚܘܕܬܐ ܕܫܘܪܐ. ܘܐܘܪܒܝܩ ܡܗܝܡܢܐ ܥܣܪ ܠܝܛܖ̈ܝܢ ܕܢܒܢܐ ܒܝܬ ܣܗ̈ܕܐ ܠܛܘܒܢܝܬܐ ܡܪܝܡ. ܡܫܚܐ ܕܗܘܐ ܗܘܐ ܫ̈ܬܐ ܐܠܦ̈ܝܢ ܘܬܡܢ̈ܡܐܐ ܩܣ̈ܛܐ. ܫܩܠܗ ܡܢܗܘܢ ܗܘ ܗܓܡܘܢܐ ܘܦܩܕ ܕܢܢܗܪ ܒܐܣ̈ܛܘܐ ܕܡܕܝܢܐ. ܘܣܓܝ ܒܥܘ ܡܢܗ ܦܪܡܘܢܖ̈ܐ ܡܛܠܬܗ ܘܠܐ ܐܬܛܦܝܤ. ܘܕܠܐ ܢܣܬܒܪ ܕܠܗܝ̈ܟܠܐ ܕܒܢ̈ܝܢ ܠܐܠܗܐ ܫܐܛ ܝܗܒ ܡܢ ܕܝܠܗ ܠܟܠ ܒܝܬ ܣ̈ܗܕܐ ܡ̈ܬܝܢ ܩܣ̈ܛܐ.

'The emperor also gave twenty pounds to the bishop for expenses and the renewal of the wall, while Urbicius the eunuch (gave him) ten pounds to build a martyrion to the blessed Mary. However, the governor (i.e. Eulogius) took away the (supply of) oil being given to the martyria and monasteries from the oil-store, which came to six thousand and eight hundred xestai, and gave orders that it should be used for illumination in the city’s colonnades. The vergers vigorously petitioned him about this, but he could not be persuaded. He did, however, give two hundred xestai from his own account to every martyrion, lest it be thought that he cared nothing for temples built for God.'

Ed. Chabot 1927-1949, v. 1, p. 308; trans. Trombley and Watt 2000, pp. 106-107.
Additional file 2 of Clinical, biochemical, and genetic spectrum of MADD in a South African cohort: an ICGNMD study
Creators: name: Bisschoff, Michelle
name: Smuts, Izelle
name: Dercksen, Marli
name: Schoonen, Maryke
name: Vorster, Barend C.
name: van der Watt, George
name: Spencer, Careni
name: Naidu, Kireshnee
name: Henning, Franclo
name: Meldau, Surita
name: McFarland, Robert
name: Taylor, Robert W.
name: Patel, Krutik
name: Fassad, Mahmoud R.
name: Vandrovcova, Jana
name: Wanders, Ronald J. A.
name: van der Westhuizen, Francois H.
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2. Additional Metabolic Information.
Inference for ARMA time series with mildly varying trend
Creators: name: Yi, Yinghuai
name: Song, Zening
name: Yang, Lijian
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Statistical inference is studied for ARMA time series with a mildly varying smooth trend. Following properly calibrated B-spline estimation of the trend, approximates of the unobserved ARMA series are used instead to estimate ARMA parameters by maximum likelihood. The parameter estimates are shown to be oracally efficient in the sense that they are asymptotically as efficient as if the true trend function was known and removed to obtain the true ARMA series. The mildly varying trend function is estimated by Nadaraya–Watson method with asymptotically correct simultaneous confidence band (SCB). The SCB sprawls over an interval that eventually covers the half real line, instead of a bounded interval in the existing literature, with asymptotic width of the SCB dependent on ARMA coefficients. Simulation experiments corroborate the theoretical findings.
sj-pdf-1-pie-10.1177_0954408920979221 - Supplemental material for An efficient variance-based global sensitivity index based on C-DRM and Taylor expansion
Creators: name: Wang, Wenxuan
name: Wang, Xiaoyi
Publisher: name: SAGE Journals
Year: 2020
Subjects: Engineering not elsewhere classified
Materials Engineering not elsewhere classified

description: Supplemental material, sj-pdf-1-pie-10.1177_0954408920979221 for An efficient variance-based global sensitivity index based on C-DRM and Taylor expansion by Wenxuan Wang and Xiaoyi Wang in Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering