title: ÐÐ¾Ð½ÑÑÐ¾Ð»Ñ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ ÑÐ¿ÑÑÐ³Ð¾ÑÑÐ¸ Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð¹ ÑÐºÐ°Ð½Ð¸ Ð² Ð¾Ð±Ð»Ð°ÑÑÐ¸ Ð°Ð±Ð»ÑÑÐ¸Ð¸ Ð²ÑÑÐ¾ÐºÐ¾Ð¸Ð½ÑÐµÐ½ÑÐ¸Ð²Ð½ÑÐ¼ ÑÐ¾ÐºÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐ¼ ÑÐ»ÑÑÑÐ°Ð·Ð²ÑÐºÐ¾Ð¼
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Control of changes in the elasticity of biological tissue in the ablation area with high-intensity focused ultrasound
Creators: name: ÐÐµÐ»ÑÐºÐ¾Ð²Ð°, ÐÐ½Ð°ÑÑÐ°ÑÐ¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2021
Subjects: ÐÐ²ÑÐº
ÑÐ»ÑÑÑÐ°Ð·Ð²ÑÐº
HIFU
ÑÐ»Ð°ÑÑÐ¾Ð³ÑÐ°ÑÐ¸Ñ
ÑÐ´Ð²Ð¸Ð³Ð¾Ð²Ð°Ñ Ð²Ð¾Ð»Ð½Ð°
Ð¼Ð¾Ð´ÑÐ»Ñ Ð®Ð½Ð³Ð°
ARFI
SWE
Ð°Ð±Ð»ÑÑÐ¸Ñ

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐµ Ð¼ÐµÑÐ¾Ð´Ð¸ÐºÐ¸ ÐºÐ¾Ð½ÑÑÐ¾Ð»Ñ Ð¸ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ñ Ð´Ð¾ÑÑÐ°ÑÐ¾ÑÐ½Ð¾ÑÑÐ¸ Ð°Ð±Ð»ÑÑÐ¸Ð¸ ÑÐºÐ°Ð½ÐµÐ¹ Ð²ÑÑÐ¾ÐºÐ¾Ð¸Ð½ÑÐµÐ½ÑÐ¸Ð²Ð½ÑÐ¼ ÑÐ¾ÐºÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐ¼ ÑÐ»ÑÑÑÐ°Ð·Ð²ÑÐºÐ¾Ð¼. ÐÐµÑÐ¾Ð´Ð¸ÐºÐ° Ð¿ÑÐµÐ´Ð½Ð°Ð·Ð½Ð°ÑÐµÐ½Ð° Ð´Ð»Ñ ÑÐ»ÑÑÑÐµÐ½Ð¸Ñ Ð¿Ð¾ÑÑÐµÐ±Ð¸ÑÐµÐ»ÑÑÐºÐ¸Ñ ÑÐ²Ð¾Ð¹ÑÑÐ² ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐ° Â«ÐÐ¸Ð°ÑÐµÑÂ». Ð­ÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÐµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸Ð»Ð¸ÑÑ Ð² ÑÐµÑÑÑÐµ ÑÑÐ°Ð¿Ð°. ÐÐ° Ð¿ÐµÑÐ²Ð¾Ð¼ ÑÑÐ°Ð¿Ðµ Ð±ÑÐ»Ð¸ ÑÐ¾Ð¿Ð¾ÑÑÐ°Ð²Ð»ÐµÐ½Ñ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¸Ð·Ð¼ÐµÑÐµÐ½Ð¸Ð¹ Ð¶ÐµÑÑÐºÐ¾ÑÑÐ¸ ÑÐ»Ð°ÑÑÐ¾Ð³ÑÐ°ÑÐ¸ÑÐµÑÐºÐ¸Ñ ÑÐ°Ð½ÑÐ¾Ð¼Ð¾Ð² Ð½Ð° Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÑÐµÑÐºÐ¾Ð¼ Ð¼ÐµÐ´Ð¸ÑÐ¸Ð½ÑÐºÐ¾Ð¼ Ð¿ÑÐ¸Ð±Ð¾ÑÐµ Â«ÐÐ½Ð³Ð¸Ð¾Ð´Ð¸Ð½Â», Ñ Ð´Ð°Ð½Ð½ÑÐ¼Ð¸, Ð¿Ð¾Ð»ÑÑÐ°ÐµÐ¼ÑÐ¼Ð¸ Ð½Ð° ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐµ Â«ÐÐ¸Ð°ÑÐµÑÂ». ÐÐ° Ð²ÑÐ¾ÑÐ¾Ð¼ ÑÑÐ°Ð¿Ðµ Ð±ÑÐ»Ð¸ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ñ Ð½Ð¾Ð²ÑÐµ Ð¼ÐµÑÐ¾Ð´Ð¸ÐºÐ¸ Ð¸Ð·Ð¼ÐµÑÐµÐ½Ð¸Ñ Ð¶ÐµÑÑÐºÐ¾ÑÑÐ¸ Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ ÑÐºÐ°Ð½ÐµÐ¹, ÑÐµÐ°Ð»Ð¸Ð·Ð¾Ð²Ð°Ð½Ð½ÑÐµ Ð² ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑÐµ Â«ÐÐ¸Ð°ÑÐµÑÂ»: ARFI HIFU, SWE HIFU. ÐÐ° ÑÑÐµÑÑÐµÐ¼ ÑÑÐ°Ð¿Ðµ Ð¸Ð·ÑÑÐ°Ð»Ð¾ÑÑ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ ÑÑÐµÐ¿ÐµÐ½Ð¸ Ð°Ð±Ð»ÑÑÐ¸Ð¸ Ð½Ð° Ð¶ÐµÑÑÐºÐ¾ÑÑÑ ÑÐºÐ°Ð½ÐµÐ¹. ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð° Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÑ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð¶ÐµÑÑÐºÐ¾ÑÑÐ¸ ÑÐºÐ°Ð½ÐµÐ¹ Ð¾Ñ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÐ¾Ð² HIFU Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ. Ð Ð½Ð° Ð¿Ð¾ÑÐ»ÐµÐ´Ð½ÐµÐ¼, ÑÐµÑÐ²ÐµÑÑÐ¾Ð¼ ÑÑÐ°Ð¿Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¾ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ðµ Ð¶ÐµÑÑÐºÐ¾ÑÑÐ¸ ÑÐºÐ°Ð½ÐµÐ¹ Ð² Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÐ¸ Ð¾Ñ ÐºÐ¾Ð»Ð¸ÑÐµÑÑÐ²Ð° ÑÐµÑÐ°Ð¿ÐµÐ²ÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ð¹ Ð½ÐµÐ±Ð¾Ð»ÑÑÐ¾Ð¹ Ð´Ð¾Ð·Ñ. Ð Ð°ÑÑÐ¼Ð°ÑÑÐ¸Ð²Ð°Ð»Ð°ÑÑ Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½Ð¾ÑÑÑ ÐºÐ¾Ð½ÑÑÐ¾Ð»Ð¸ÑÑÐµÐ¼Ð¾Ð¹ Ð°Ð±Ð»ÑÑÐ¸Ð¸ ÑÐºÐ°Ð½ÐµÐ¹ Ð¿ÑÑÐµÐ¼ Ð¼Ð½Ð¾Ð³Ð¾ÐºÑÐ°ÑÐ½Ð¾Ð³Ð¾ ÑÐµÑÐ°Ð¿ÐµÐ²ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð½Ð° Ð¿Ð¾ÑÐ°Ð¶ÐµÐ½Ð½ÑÑ Ð¾Ð±Ð»Ð°ÑÑÑ, Ð³Ð´Ðµ Ð¼ÐµÐ¶Ð´Ñ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸ÑÐ¼Ð¸ Ð¿ÑÐ¾Ð¸ÑÑÐ¾Ð´Ð¸Ñ ÐºÐ¾Ð½ÑÑÐ¾Ð»Ñ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð¶ÐµÑÑÐºÐ¾ÑÑÐ¸. ÐÐ¾ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐ°Ð¼ Ð¸Ð·Ð¼ÐµÑÐµÐ½Ð¸Ð¹ Ð¼Ð¾Ð¶Ð½Ð¾ ÑÑÐ²ÐµÑÐ¶Ð´Ð°ÑÑ, ÑÑÐ¾ ÐºÐ¾Ð¼Ð¿Ð»ÐµÐºÑ Â«ÐÐ¸Ð°ÑÐµÑÂ» Ð¸Ð·Ð¼ÐµÑÑÐµÑ Ð¶ÐµÑÑÐºÐ¾ÑÑÑ ÑÐºÐ°Ð½ÐµÐ¹ Ð² ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÑ ÑÐµÐ¶Ð¸Ð¼Ð°Ñ Ñ Ð¿ÑÐ¸ÐµÐ¼Ð»ÐµÐ¼Ð¾Ð¹ ÑÐ¾ÑÐ½Ð¾ÑÑÑÑ. Ð£ÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ñ Ð¾Ð¿ÑÐ¸Ð¼Ð°Ð»ÑÐ½ÑÐµ Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÑ ÑÐµÐ¶Ð¸Ð¼Ð¾Ð² ARFI HIFU Ð¸ SWE HIFU Ð´Ð»Ñ Ð¸Ð·Ð¼ÐµÑÐµÐ½Ð¸Ñ Ð¶ÐµÑÑÐºÐ¾ÑÑÐ¸, Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð° Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½Ð¾ÑÑÑ Ð¼Ð½Ð¾Ð³Ð¾ÐºÑÐ°ÑÐ½Ð¾Ð³Ð¾ ÑÐµÑÐ°Ð¿ÐµÐ²ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ. ÐÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð° Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÑ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð¶ÐµÑÑÐºÐ¾ÑÑÐ¸ ÑÐºÐ°Ð½ÐµÐ¹ Ð¾Ñ Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÐ¾Ð² Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ, Ð¿ÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½ ÐºÑÐ¸ÑÐµÑÐ¸Ð¹ Ð´Ð¾ÑÑÐ°ÑÐ¾ÑÐ½Ð¾ÑÑÐ¸ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ.
description: This work is devoted to the development of a technique for monitoring and determining the sufficiency of tissue ablation by high-intensity focused ultrasound. The technique is designed to improve the consumer properties of the "Diater" complex. The experimental studies were carried out in four stages. At the first stage, the results of measuring the stiffness of elastographic phantoms on the "Angiodin" diagnostic medical device were compared with the data obtained on the "Diater" complex. At the second stage, new methods for measuring the stiffness of biological tissues, implemented in the "Diater" complex, were investigated: ARFI HIFU, SWE HIFU. At the third stage, the effect of the degree of ablation on tissue stiffness was studied. The dependence of changes in tissue stiffness on various parameters of HIFU exposure was investigated. And at the last, fourth stage, the change in tissue stiffness was investigated depending on the number of therapeutic effects of a small dose. The possibility of controlled ablation of tissues by means of multiple therapeutic effects on the affected area was considered, where the change in stiffness is controlled between exposures. According to the measurement results, it can be argued that the "Diater" complex measures tissue stiffness in various modes with acceptable accuracy. The optimal parameters of the ARFI HIFU and SWE HIFU modes for measuring stiffness have been established, the possibility of multiple therapeutic effects has been investigated. The dependence of the change in tissue stiffness on the parameters of exposure is determined, a criterion for the sufficiency of exposure is proposed.