Genetic polymorphism of <i>Arg<sup>213</sup>His</i> variant in the <i>SULT1A1</i> gene is associated with reduced susceptibility to lung cancer in North Indian population
Creators: name: Walia, Harleen Kaur
name: Singh, Navneet
name: Sharma, Siddharth
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Sulfotransferases (SULTs) are phase II detoxification enzymes that is involved in the biotransformation of many compounds including tobacco carcinogens. A polymorphism in the S<i>ULT1A1</i> (<i>Arg<sup>213</sup>His</i>) gene results in reduced enzyme activity.We investigated the association between the <i>SULT1A1</i> (Arg<sup>213</sup>/His) genotype and lung cancer (LC). This case-control study comprised of 550 cases and controls, matched on age, gender and smoking status.The variant genotype exhibited no association with LC risk, even after stratification on basis of histological subtypes. Male LC patients carrying the variant <i>His<sup>213</sup></i> allele (<b><i>p</i> = 0.02</b>) did not exhibit an increased risk towards LC. Smokers harbouring the <i>Arg/His</i> genotype did demonstrate a reduced risk towards LC (AOR = 0.70; <b><i>p</i> = 0.019</b>). Furthermore, the LC subjects who were heavy smokers and harbouring the <i>Arg/His</i> genotype (AOR = 0.28; <b><i>p</i> = 0.019</b>) did not show a genetic predisposition towards LC susceptibility. The subjects who smoked pack years of above 40 and carrying the <i>His/His</i> (AOR = 0.28; <b><i>p</i> = 0.036</b>) genotype were found to have a reduced risk for LC. Furthermore, 473 subjects were analysed in regards to overall survival, wherein the <i>His/His</i> genotype exhibited better OS than <i>Arg/Arg</i> genotype (11.30 vs. 8.07 months).This study provides evidence of no genetic predisposition towards LC risk associated with <i>SULT1A1 Arg<sup>213</sup>His</i> polymorphism in relation to tobacco smoking. Sulfotransferases (SULTs) are phase II detoxification enzymes that is involved in the biotransformation of many compounds including tobacco carcinogens. A polymorphism in the S<i>ULT1A1</i> (<i>Arg<sup>213</sup>His</i>) gene results in reduced enzyme activity. We investigated the association between the <i>SULT1A1</i> (Arg<sup>213</sup>/His) genotype and lung cancer (LC). This case-control study comprised of 550 cases and controls, matched on age, gender and smoking status. The variant genotype exhibited no association with LC risk, even after stratification on basis of histological subtypes. Male LC patients carrying the variant <i>His<sup>213</sup></i> allele (<b><i>p</i> = 0.02</b>) did not exhibit an increased risk towards LC. Smokers harbouring the <i>Arg/His</i> genotype did demonstrate a reduced risk towards LC (AOR = 0.70; <b><i>p</i> = 0.019</b>). Furthermore, the LC subjects who were heavy smokers and harbouring the <i>Arg/His</i> genotype (AOR = 0.28; <b><i>p</i> = 0.019</b>) did not show a genetic predisposition towards LC susceptibility. The subjects who smoked pack years of above 40 and carrying the <i>His/His</i> (AOR = 0.28; <b><i>p</i> = 0.036</b>) genotype were found to have a reduced risk for LC. Furthermore, 473 subjects were analysed in regards to overall survival, wherein the <i>His/His</i> genotype exhibited better OS than <i>Arg/Arg</i> genotype (11.30 vs. 8.07 months). This study provides evidence of no genetic predisposition towards LC risk associated with <i>SULT1A1 Arg<sup>213</sup>His</i> polymorphism in relation to tobacco smoking.