cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Exclusion Process: A paradigm for non-equilibrium behaviour
Creators: name: Mallick, Kirone
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: In these lectures, we shall present some remarkable results that have been obtained for systems far from equilibrium during the last two decades. We shall put a special emphasis on the concept of large deviation functions that provide us with a unified description of many physical situations. These functions are expected to play, for systems far from equilibrium, a role akin to that of the thermodynamic potentials. These concepts will be illustrated by exact solutions of the Asymmetric Exclusion Process, a paradigm for non-equilibrium statistical physics.
description: Proceedings of the 13th International Summer School on Fundamental Problems in Statistical Physics (Edited by Marco Baiesi, Enrico Carlon and Andrea Parmeggiani)
Symptomatic malaria enhances protection from reinfection with homologous Plasmodium falciparum parasites
Creators: name: Mangeni, Judith N.
name: Zeno, Erica E.
name: Markwalter, Christine F.
name: Sumner, Kelsey M.
name: Prudhomme-O’Meara, Wendy
name: Petersen, Jens E. V.
name: Freedman, Elizabeth
name: Abel, Lucy
name: Taylor, Steve M.
name: Obala, Andrew A.
Publisher: name: Public Library of Science
Year: 2023

description: A signature remains elusive of naturally-acquired immunity against Plasmodium falciparum. We identified P. falciparum in a 14-month cohort of 239 people in Kenya, genotyped at immunogenic parasite targets expressed in the pre-erythrocytic (circumsporozoite protein, CSP) and blood (apical membrane antigen 1, AMA-1) stages, and classified into epitope type based on variants in the DV10, Th2R, and Th3R epitopes in CSP and the c1L region of AMA-1. Compared to asymptomatic index infections, symptomatic malaria was associated with reduced reinfection by parasites bearing homologous CSP-Th2R (adjusted hazard ratio [aHR]:0.63; 95% CI:0.45–0.89; p = 0.008) CSP-Th3R (aHR:0.71; 95% CI:0.52–0.97; p = 0.033), and AMA-1 c1L (aHR:0.63; 95% CI:0.43–0.94; p = 0.022) epitope types. The association of symptomatic malaria with reduced hazard of homologous reinfection was strongest for rare epitope types. Symptomatic malaria provides more durable protection against reinfection with parasites bearing homologous epitope types. The phenotype represents a legible molecular epidemiologic signature of naturally-acquired immunity by which to identify new antigen targets.
Cytokinins. New Insights into a Classic Phytohormone
Creators: name: Kieber, J. J.
name: Haberer, G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Cytokinins were discovered in the search for factors that promoted division of plant cells in culture. Naturally occurring cytokinins are N 6-substituted adenine derivatives that generally contain an isoprenoid derivative side chain. These hormones influence numerous aspects of plant development and
Additional file 2: of Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node
Creators: name: Pul, Kim Van
name: Vuylsteke, Ronald
name: Rieneke Van De Ven
name: Velde, Elisabeth Te
name: Rutgers, Emiel
name: Petrousjka Van Den Tol
name: Stockmann, Hein
name: Gruijl, Tanja De
Publisher: name: Figshare
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Plant Biology
subject: FOS: Biological sciences

description: Figure S1. Flowcytometric gating of cell subsets. Gating strategies for the DC subsets as well as Tregs and MDSC and for T cell activation/checkpoint markers (PDF 495 kb)
Universal hyperparallel hybrid photonic quantum gates with dipole-induced transparency in the weak-coupling regime
Creators: name: Ren, Bao-Cang
name: Wang, Guan-Yu
name: Deng, Fu-Guo
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present the dipole induced transparency (DIT) of a diamond nitrogen-vacancy center embedded in a photonic crystal cavity coupled to two waveguides, and it is obvious with the robust and flexible reflectance and transmittance difference of circularly polarized lights between the uncoupled and the coupled cavities even in the bad cavity regime (the Purcell regime). With this DIT, we propose two universal hyperparallel hybrid photonic quantum logic gates, including a hybrid hyper-controlled-not gate and a hybrid hyper-Toffoli gate, on photon systems in both the polarization and the spatial-mode degrees of freedom (DOFs), which are equal to two identical quantum logic gates operating simultaneously on the systems in one DOF. They can be used to perform more quantum operations with less resources in the quantum information protocols with multi-qubit systems in several DOFs, which may depress the resources consumed and the photonic dissipation. Moreover, they are more robust against asymmetric environment noise in the weak-coupling regime, compared with the integration of two cascaded quantum logic gates in one DOF.
description: 10 pages, 8 figures
Lower bound on the electroweak wall velocity from hydrodynamic instability
Creators: name: Megevand, Ariel
name: Membiela, Federico Agustin
name: Sanchez, Alejandro D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The subsonic expansion of bubbles in a strongly first-order electroweak phase transition is a convenient scenario for electroweak baryogenesis. For most extensions of the Standard Model, stationary subsonic solutions (i.e., deflagrations) exist for the propagation of phase transition fronts. However, deflagrations are known to be hydrodynamically unstable for wall velocities below a certain critical value. We calculate this critical velocity for several extensions of the Standard Model and compare with an estimation of the wall velocity. In general, we find a region in parameter space which gives stable deflagrations as well as favorable conditions for electroweak baryogenesis.
description: 30 pages, 7 figures. v2: Paper reorganized (some parts put in an appendix). Comments added. Results and conclusions unchanged. Version accepted in JCAP
Alexander Solschenizyn: Humanist besonderer Art
Creators: name: Ericson, Edward E.
Publisher: name: Internationale katholische Zeitschrift Communio
Year: 2022

description: Internationale katholische Zeitschrift Communio, Bd. 5 Nr. 1 (1976): Internationale katholische Zeitschrift Communio, Band 5, Heft 1
Early Embryo Development in Fucus distichus Is Auxin Sensitive
Creators: name: Basu, S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Auxin and polar auxin transport have been implicated in controlling embryo development in land plants. The goal of these studies was to determine if auxin and auxin transport are also important during the earliest stages of development in embryos of the brown alga Fucus distichus. Indole-3-acetic acid (IAA) was identified in F. distichus embryos and mature tissues by gas chromatography-mass spectroscopy. F. distichus embryos accumulate [3H]IAA and an inhibitor of IAA efflux, naphthylphthalamic acid (NPA), elevates IAA accumulation, suggesting the presence of an auxin efflux protein complex similar to that found in land plants. F. distichus embryos normally develop with a single unbranched rhizoid, but growth on IAA leads to formation of multiple rhizoids and growth on NPA leads to formation of embryos with branched rhizoids, at concentrations that are active in auxin accumulation assays. The effects of IAA and NPA are complete before 6 h after fertilization (AF), which is before rhizoid germination and cell division. The maximal effects of IAA and NPA are between 3.5 and 5 h AF and 4 and 5.5 h AF, respectively. Although, the location of the planes of cell division was significantly altered in NPA- and IAA-treated embryos, these abnormal divisions occurred after abnormal rhizoid initiation and branching was observed. The results of this study suggest that auxin acts in the formation of apical basal patterns in F. distichus embryo development.
PREVALENCE OF HELICOBACTER PYLORI INFECTION IN DISTRICT MARDAN
Creators: name: HUMA FATIMA
name: NARGIS SHAHEEN
name: SUMBAL HALEEM
name: ATIYA IQBAL
name: GHANIA AJAZ NADEEM
name: JALWA ARSHAD
Publisher: name: Zenodo
Year: 2023
Subjects: H. pylori, Age wise, Gender wise, Area wise

description: Abstract
Helicobacter pylori are endemic, affect about half population of the world, and causes gastric ulcer, peptic ulcer, gastric cancer and classified as a class I carcinogen by the WHO.  It is estimated 4.4 billion people were affected globally. This study was conducted to find out the prevalence of H. pylori infection in different region of Mardan, KPK via questionnaire and personal interaction. For this purpose different hospitals were visited in order to collect the data of require patient after the consent approval from their parents and guardians. The detail information about, age, gender and area were collected from the subject of H. pylori infection.  Total 260 patients were included in the study. The overall prevalence of H. pylori was found 46%. The gender wise analysis showed that the prevalence of H. pylori infection was dominant in male 55% as compared to female 45%. The age wise prevalence of infection in 10 to 25 years age group was found to be 58% and 26 to 40 years was found 34%. While the 40 and above years age group was 8%. According to the gender wise prevalence, male was more affected as compare to female. The age wise survey predicted that the lower age group (10 to 25 year) was more affected as compared to middle and higher age groups. The result also showed that urban areas were more affected by H. pylori as compare to rural areas.
The role of human milk nutrients in preventing necrotizing enterocolitis
Creators: name: Orgel K.A.
name: Clodfelter L.G.
name: Good M.
name: Singh D.K.
name: Frazer L.C.
name: Miller C.M.
name: Sami A.S.
Publisher: name: Frontiers Media S.A.
Year: 2023

description: Necrotizing enterocolitis (NEC) is an intestinal disease that primarily impacts preterm infants. The pathophysiology of NEC involves a complex interplay of factors that result in a deleterious immune response, injury to the intestinal mucosa, and in its most severe form, irreversible intestinal necrosis. Treatments for NEC remain limited, but one of the most effective preventative strategies for NEC is the provision of breast milk feeds. In this review, we discuss mechanisms by which bioactive nutrients in breast milk impact neonatal intestinal physiology and the development of NEC. We also review experimental models of NEC that have been used to study the role of breast milk components in disease pathophysiology. These models are necessary to accelerate mechanistic research and improve outcomes for neonates with NEC.
PREVALENCE OF HELICOBACTER PYLORI INFECTION IN DISTRICT MARDAN
Creators: name: HUMA FATIMA
name: NARGIS SHAHEEN
name: SUMBAL HALEEM
name: ATIYA IQBAL
name: GHANIA AJAZ NADEEM
Publisher: name: Zenodo
Year: 2023
Subjects: H. pylori, Age wise, Gender wise, Area wise

description: Abstract
Helicobacter pylori are endemic, affect about half population of the world, and causes gastric ulcer, peptic ulcer, gastric cancer and classified as a class I carcinogen by the WHO.  It is estimated 4.4 billion people were affected globally. This study was conducted to find out the prevalence of H. pylori infection in different region of Mardan, KPK via questionnaire and personal interaction. For this purpose different hospitals were visited in order to collect the data of require patient after the consent approval from their parents and guardians. The detail information about, age, gender and area were collected from the subject of H. pylori infection.  Total 260 patients were included in the study. The overall prevalence of H. pylori was found 46%. The gender wise analysis showed that the prevalence of H. pylori infection was dominant in male 55% as compared to female 45%. The age wise prevalence of infection in 10 to 25 years age group was found to be 58% and 26 to 40 years was found 34%. While the 40 and above years age group was 8%. According to the gender wise prevalence, male was more affected as compare to female. The age wise survey predicted that the lower age group (10 to 25 year) was more affected as compared to middle and higher age groups. The result also showed that urban areas were more affected by H. pylori as compare to rural areas.
The Role of RNA Sensors in Regulating Innate Immunity to Gammaherpesviral Infections
Creators: name: Damania, Blossom
name: Zhang, Huirong
name: Sandhu, Praneet K.
Publisher: name: MDPI
Year: 2023

description: Kaposi’s sarcoma-associated herpesvirus (KSHV) and the Epstein–Barr virus (EBV) are double-stranded DNA oncogenic gammaherpesviruses. These two viruses are associated with multiple human malignancies, including both B and T cell lymphomas, as well as epithelial- and endothelial-derived cancers. KSHV and EBV establish a life-long latent infection in the human host with intermittent periods of lytic replication. Infection with these viruses induce the expression of both viral and host RNA transcripts and activates several RNA sensors including RIG-I-like receptors (RLRs), Toll-like receptors (TLRs), protein kinase R (PKR) and adenosine deaminases acting on RNA (ADAR1). Activation of these RNA sensors induces the innate immune response to antagonize the virus. To counteract this, KSHV and EBV utilize both viral and cellular proteins to block the innate immune pathways and facilitate their own infection. In this review, we summarize how gammaherpesviral infections activate RNA sensors and induce their downstream signaling cascade, as well as how these viruses evade the antiviral signaling pathways to successfully establish latent infection and undergo lytic reactivation.
Kommentar zu Teilhards Brief (»Humani Generis«)
Creators: name: Soulages, Gérard
Publisher: name: Internationale katholische Zeitschrift Communio
Year: 2022

description: Internationale katholische Zeitschrift Communio, Bd. 5 Nr. 1 (1976): Internationale katholische Zeitschrift Communio, Band 5, Heft 1
Efficient modelling of particle collisions using a non-linear viscoelastic contact force
Creators: name: Ray, Shouryya
name: Kempe, Tobias
name: Fröhlich, Jochen
Publisher: name: arXiv
Year: 2015
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: In this paper the normal collision of spherical particles is investigated. The particle interaction is modelled in a macroscopic way using the Hertzian contact force with additional linear damping. The goal of the work is to develop an efficient approximate solution of sufficient accuracy for this problem which can be used in soft-sphere collision models for Discrete Element Methods and for particle transport in viscous fluids. First, by the choice of appropriate units, the number of governing parameters of the collision process is reduced to one, which is a simple combination of known material parameters as well as initial conditions. It provides a dimensionless parameter that characterizes all such collisions up to dynamic similitude. Next, a rigorous calculation of the collision time and restitution coefficient from the governing equations, in the form of a series expansion in this parameter is provided. Such a calculation based on first principles is particularly interesting from a theoretical perspective. Since the governing equations present some technical difficulties, the methods employed are also of interest from the point of view of the analytical technique. Using further approximations, compact expressions for the restitution coefficient and the collision time are then provided. These are used to implement an approximate algebraic rule for computing the desired stiffness and damping in the framework of the adaptive collision model (Kempe & Fröhlich, J. Fluid Mech., 709: 445-489, 2012). Numerical tests with binary as well as multiple particle collisions are reported to illustrate the accuracy of the proposed method and its superiority in terms of numerical efficiency.
description: Accepted for publication in present form by Int. J. Multiphase Flow
Training augmentation using additive sensory noise in a lunar rover navigation task
Creators: name: Clark, Torin K.
name: Jonsen, Anna
name: Szafir, Daniel
name: Sherman, Sage O.
name: Schlittenhart, Michael
name: Lewis, Quinlan
name: Anderson, Allison P.
Publisher: name: Frontiers Media S.A.
Year: 2023

description: Background The uncertain environments of future space missions means that astronauts will need to acquire new skills rapidly; thus, a non-invasive method to enhance learning of complex tasks is desirable. Stochastic resonance (SR) is a phenomenon where adding noise improves the throughput of a weak signal. SR has been shown to improve perception and cognitive performance in certain individuals. However, the learning of operational tasks and behavioral health effects of repeated noise exposure aimed to elicit SR are unknown. Objective We evaluated the long-term impacts and acceptability of repeated auditory white noise (AWN) and/or noisy galvanic vestibular stimulation (nGVS) on operational learning and behavioral health.MethodsSubjects (n = 24) participated in a time longitudinal experiment to access learning and behavioral health. Subjects were assigned to one of our four treatments: sham, AWN (55 dB SPL), nGVS (0.5 mA), and their combination to create a multi-modal SR (MMSR) condition. To assess the effects of additive noise on learning, these treatments were administered continuously during a lunar rover simulation in virtual reality. To assess behavioral health, subjects completed daily, subjective questionnaires related to their mood, sleep, stress, and their perceived acceptance of noise stimulation. Results We found that subjects learned the lunar rover task over time, as shown by significantly lower power required for the rover to complete traverses (p < 0.005) and increased object identification accuracy in the environment (p = 0.05), but this was not influenced by additive SR noise (p = 0.58). We found no influence of noise on mood or stress following stimulation (p > 0.09). We found marginally significant longitudinal effects of noise on behavioral health (p = 0.06) as measured by strain and sleep. We found slight differences in stimulation acceptability between treatment groups, and notably nGVS was found to be more distracting than sham (p = 0.006). Conclusion Our results suggest that repeatedly administering sensory noise does not improve long-term operational learning performance or affect behavioral health. We also find that repetitive noise administration is acceptable in this context. While additive noise does not improve performance in this paradigm, if it were used for other contexts, it appears acceptable without negative longitudinal effects.
How to conduct challenge test studies assessing growth potential or maximum growth rate according to the new EURL Lm guidelines and ISO standard
Creators: name: Iannetti, Luigi
Publisher: name: Zenodo
Year: 2022
Subjects: ready to eat
predictive microbiology
fate studies

description: Presentation given at the Webinar “Latest guidelines from EU and ISO for conducting shelf life studies on Listeria monocytogenes in RTE foods” on the 25th May 2022
Von Abraham zu Prometheus
Creators: name: Buttiglione, Rocco
name: Scola, Angelo
Publisher: name: Internationale katholische Zeitschrift Communio
Year: 2022

description: Internationale katholische Zeitschrift Communio, Bd. 5 Nr. 1 (1976): Internationale katholische Zeitschrift Communio, Band 5, Heft 1
Role of a Heterotrimeric G Protein in Regulation of Arabidopsis Seed Germination
Creators: name: Ullah, H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Seed germination is regulated by many signals. We investigated the possible involvement of a heterotrimeric G protein complex in this signal regulation. Seeds that carry a protein null mutation in the gene encoding the alpha subunit of the G protein in Arabidopsis (GPA1) are 100-fold less responsive to gibberellic acid (GA), have increased sensitivity to high levels of Glc, and have a near-wild-type germination response to abscisic acid and ethylene, indicating that GPA1 does not directly couple these signals in germination control. Seeds ectopically expressing GPA1 are at least a million-fold more responsive to GA, yet still require GA for germination. We conclude that the GPA1 indirectly operates on the GA pathway to control germination by potentiation. We propose that this potentiation is directly mediated by brassinosteroids (BR) because the BR response and synthesis mutants, bri1-5 and det2-1, respectively, share the same GA sensitivity as gpa1 seeds. Furthermore, gpa1 seeds are completely insensitive to brassinolide rescue of germination when the level of GA in seeds is reduced. A lack of BR responsiveness is also apparent in gpa1 roots and hypocotyls suggesting that BR signal transduction is likely coupled by a heterotrimeric G protein at various points in plant development.
Additional file 5: of Delayed loss of UBE3A reduces the expression of Angelman syndrome-associated phenotypes
Creators: name: Sonzogni, Monica
name: Hakonen, Johanna
name: Kleijn, Mireia Bernabé
name: Silva-Santos, Sara
name: Judson, Matthew
name: Philpot, Benjamin
name: Woerden, Geeske
name: Elgersma, Ype
Publisher: name: Figshare
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Figure S2. Ube3a gene deletion in juvenile and adult mice does not recapitulate the phenotypes observed in embryonically deleted Ube3a mice. A. Schematic depicting Ube3a gene deletion at early embryonic age, juvenile age (3 weeks) and adult age (12 weeks). B-F. Behavioral tasks performed with Creembryo;Ube3amflox/p+ (N for WT-Creembryo−/ WT-Creembryo+ / Ube3amflox/p+-Creembryo−/ Ube3amflox/p+-Creembryo+ mice = 15/group) and CreERT;Ube3amflox/p+ mice (Juvenile deletion: N for WT-OIL/ WT-TAM / Ube3amflox/p+-VEH/ Ube3amflox/p+-TAM mice = 11, 13, 14, 16; Adult deletion: N for WT-OIL/ WT-TAM / Ube3amflox/p+-VEH/ Ube3amflox/p+-TAM mice = 15/group) . Juvenile and adult Ube3a gene deletion results in deficits in the forced swim test. Asterisks indicate the effect of genotype. Data shown are means with SEM. See methods and Additional file 6 for statistical tests and sample sizes. (PDF 401 kb)
OROL DENGIZI QURIGAN TUBIDA YASHIL QOPLAMALARNI PARVARISHLASH AGROTEXNIKASI
Creators: name: Baltaniyazov, Jaqsibay
name: Madraimov, Rustamjon
Publisher: name: Zenodo
Year: 2023

description: Ushbu maqolada qurigan Orol dengizi tubida yashil qoplamalar barpo etishda o`simlik turlari, ularni ko`paytirish va parvarishlash agrotexnikasi bo`yicha ma`lumotlar keltirilgan. Saksovul o`simligi cho`l mintaqalarida yashil qoplamalar barpo etishda dominant o`simlik turi hisoblanadi va boshqa o`simlik turlarining ko`payishi va rivojlanishi uchun mo`tadil sharoit yaratadi.
Spectral properties of the post-merger gravitational-wave signal from binary neutron stars
Creators: name: Takami, Kentaro
name: Rezzolla, Luciano
name: Baiotti, Luca
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Extending previous work by a number of authors, we have recently presented a new approach in which the detection of gravitational waves from merging neutron star binaries can be used to determine the equation of state of matter at nuclear density and hence the structure of neutron stars. In particular, after performing a large number of numerical-relativity simulations of binaries with nuclear equations of state, we have found that the post-merger emission is characterized by two distinct and robust spectral features. While the high-frequency peak was already shown to be associated with the oscillations of the hypermassive neutron star produced by the merger and to depend on the equation of state, we have highlighted that the low-frequency peak is related to the merger process and to the total compactness of the stars in the binary. This relation is essentially universal and provides a powerful tool to set tight constraints on the equation of state. We here provide additional information on the extensive analysis performed, illustrating the methods used, the tests considered, as well as the robustness of the results. We also discuss additional relations that can be deduced when exploring the data and how these correlate with various properties of the binary. Finally, we present a simple mechanical toy model that explains the main spectral features of the post-merger signal and can even reproduce analytically the complex waveforms emitted right after the merger.
description: 25 pages, 19 figures, 4 tables; matches version on PRD
A Reevaluation of the Role of the Heterotrimeric G Protein in Coupling Light Responses in Arabidopsis
Creators: name: Jones, A. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Previous studies implicated the involvement of a heterotrimeric G protein in red (R) and far-red (FR) light signal transduction, but these studies utilized pharmacological or gain-of-function approaches and, therefore, are indirect tests. Here, we reexamine the role of the single canonical heterotrimeric G protein in R and FR control of hypocotyl growth using a loss-of-function approach. Single- and double-null mutants for the GPA1, AGB1 genes encoding the alpha and beta subunit of the heterotrimeric G protein, respectively, have wild-type sensitivity to R and FR. Ectopic overexpression of wild type and a constitutive active form of the alpha subunit and of the wild-type beta subunit had no effect that can be unequivocally attributed to altered R and FR responsiveness. These results preclude a direct role for the heterotrimeric G complex in R and FR transduction in Arabidopsis leading to growth control in the hypocotyl.
Agrobacterium-Mediated Root Transformation Is Inhibited by Mutation of an Arabidopsis Cellulose Synthase-Like Gene
Creators: name: Zhu, Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Agrobacterium-mediated plant genetic transformation involves a complex interaction between the bacterium and the host plant. Relatively little is known about the role plant genes and proteins play in this process. We previously identified an Arabidopsis mutant, rat4, that is resistant to Agrobacterium transformation. We show here that rat4 contains a T-DNA insertion into the 3′-untranslated region of the cellulose synthase-like gene CSLA9. CSLA9 transcripts are greatly reduced in the rat4 mutant. Genetic complementation of rat4 with wild-type genomic copies of the CSLA9 gene restores both transformation competence and the wild-type level of CSLA9 transcripts. The CSLA9 promoter shows a distinct pattern of expression in Arabidopsis plants. In particular, the promoter is active in the elongation zone of roots, the root tissue that we previously showed is most susceptible to Agrobacterium-mediated transformation. Disruption of the CSLA9 gene in the rat4 mutant results in reduced numbers and rate of growth of lateral roots and reduced ability of the roots to bind A. tumefaciens cells under certain conditions. No major differences in the linkage structure of the non-cellulosic polysaccharides could be traced to the defective CSLA9 gene.
Additional file 9: of Delayed loss of UBE3A reduces the expression of Angelman syndrome-associated phenotypes
Creators: name: Sonzogni, Monica
name: Hakonen, Johanna
name: Kleijn, Mireia Bernabé
name: Silva-Santos, Sara
name: Judson, Matthew
name: Philpot, Benjamin
name: Woerden, Geeske
name: Elgersma, Ype
Publisher: name: Figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Figure S5. Behavioral test battery in mice older than 20 weeks of age. A. Accelerating rotarod in wild-type (WT) and AS mice (n = 51, 67). B. Nest building test in WT and AS mice (n = 39, 45). C. Open field test in WT and AS mice (n = 36, 57). D. Marble burying test in WT and AS mice (n = 47, 62). E. Forced swim test in WT and AS mice (n = 37, 60). All data represent mean ± SEM. A repeated measures ANOVA or t-test (or Mann Whitney U test for nonparametric data) was used for statistical comparison. All tests show a significance effect of genotype (***p
AYRIM XORIJIY DAVLATLARDA PORAXO'RLIK JINOYATLARI UCHUN JAVOBGARLIK MASALALARI
Creators: name: Ro'zimov, Zafar
Publisher: name: Zenodo
Year: 2023

description: Mazkur maqolada ayrim xorijiy davlatlarda poraxo'rlik jinoyatlari uchun javobgarlik masalalari tahlil etilgan. Shuningdek, maqolada xorijiy davlatlar va O'zbekiston Respublikasi Jinoyat kodeksidagi poraxo'rlik jinoyatlari uchun javobgarlik masalalarining o'zaro uxshash jihatlari ham yoritib berilgan.
AtCHIP, a U-Box-Containing E3 Ubiquitin Ligase, Plays a Critical Role in Temperature Stress Tolerance in Arabidopsis
Creators: name: Yan, J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: The Arabidopsis gene AtCHIP encodes a protein with three tetratricopeptide repeats and a U-box domain, which is structurally similar to the animal CHIP proteins, a new class of E3 ubiquitin ligases. Like animal CHIP proteins, AtCHIP has E3 ubiquitin ligase activity in vitro. AtCHIP is a single-copy gene, and its transcript is up-regulated by several stress conditions such as low and high temperatures. However, increased AtCHIP expression alone was not correlated with increased stress tolerance; in fact, overexpression of AtCHIP in Arabidopsis rendered plants more sensitive to both low- and high-temperature treatments. Higher electrolyte leakage was observed in leaves of AtCHIP overexpression plants after chilling temperature treatment, suggesting that membrane function is likely impaired in these plants under such a condition. These results indicate that AtCHIP plays an important role in plant cellular metabolism under temperature stress conditions.
Update on the geographic distribution of the critically endangered Urothemis edwardsii (Selys, 1849) (Odonata: Libellulidae) in northeastern Algeria
Creators: name: Zouaimia, Abdelheq
name: Zebsa, Rabah
name: Bensakhri, Zinette
name: Youcefi, Abdeldjalil
name: Bensouilah, Soufyane
name: Amari, Hichem
name: Ouakid, Mohamed-Laid
name: Houhamdi, Moussa
name: Khelifa, Rassim
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology

description: Assessing temporal changes of the distribution of threatened species is paramount for effective management. Threatened species are sensitive to environmental changes and can be extirpated rapidly due to climatic and anthropogenic effects. Here, we monitor the distribution of the locally critically endangered Urothemis edwardsii in northeastern Algeria where the species has been recovering during the last decade after being restricted to a single locality since the 1990s. During the flight seasons in 2018, 2019, and 2021, we conducted field surveys recording the number of males, females, and breeding pairs across 15 sites in northeast Algeria (El Taref province). We found the species at seven sites; reproduction was confirmed at four. In two of the sites, the species was newly recorded but showed no signs of reproduction. We confirmed the maintenance of the reproductive populations that were recently discovered. While the local conservation status of the species is better than that in the 1990s, there are still different threats that need to be addressed and conservation measures that should be implemented or reinforced to ensure maintenance as well as future expansion of the species.
Ich glaube an Gott, den Schöpfer Himmels und der Erde
Creators: name: Schmidt, Peter
Publisher: name: Internationale katholische Zeitschrift Communio
Year: 2022

description: Internationale katholische Zeitschrift Communio, Bd. 5 Nr. 1 (1976): Internationale katholische Zeitschrift Communio, Band 5, Heft 1
Non-adiabatic quantum pumping by a randomly moving quantum dot
Creators: name: Derevyanko, Stanislav
name: Waltner, Daniel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We look at the time dependent fluctuations of the electrical charge in an open 1D quantum system represented by a quantum dot experiencing random lateral motion. In essentially non-adiabatic settings we study both diffusive and ballistic (Levy) regimes of the barrier motion where the electric current as well as the net pumped electric charge experience random fluctuations over the static background. We show that in the large-time limit, $t \to \infty$, the wavefunction is naturally separated into the Berry-phase component (resulting from the singular part of the wave amplitude in the co-moving frame) and the non-adiabatic correction (arising from fast oscillating, slow decaying tails of the same amplitude). Based on this separation we report two key results: Firstly, the disorder averaged wave function and current are asymptotically mainly determined by the same Berry phase contribution that applies in the case of adiabatic motion. Secondly, after a short transition period the pumped electric charge exhibits fluctuations that grow much faster than predicted by the adiabatic theory. We also derive the exact expressions for the average propagator (in the co-moving basis representation) for the diffusive and ballistic types of motion considered.
Impact of precession on aligned-spin searches for neutron-star--black-hole binaries
Creators: name: Canton, Tito Dal
name: Lundgren, Andrew P.
name: Nielsen, Alex B.
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The inclusion of aligned-spin effects in gravitational-wave search pipelines for neutron-star--black-hole binary coalescence has been shown to increase the astrophysical reach with respect to search methods where spins are neglected completely, under astrophysically reasonable assumptions about black-hole spins. However, theoretical considerations and population synthesis models suggest that many of these binaries may have a significant misalignment between the black-hole spin and the orbital angular momentum, which could lead to precession of the orbital plane during the inspiral and a consequent loss in detection efficiency if precession is ignored. This work explores the effect of spin misalignment on a search pipeline that completely neglects spin effects and on a recently-developed pipeline that only includes aligned-spin effects. Using synthetic but realistic data, which could reasonably represent the first scientific runs of advanced-LIGO detectors, the relative sensitivities of both pipelines are shown for different assumptions about black-hole spin magnitude and alignment with the orbital angular momentum. Despite the inclusion of aligned-spin effects, the loss in signal-to-noise ratio due to precession can be as large as $40\%$, but this has a limited impact on the overall detection rate: even if precession is a predominant feature of neutron-star--black-hole binaries, an aligned-spin search pipeline can still detect at least half of the signals compared to an idealized generic precessing search pipeline.
description: 11 pages, 7 figures; version accepted by PRD
Transmission prevention behaviors in US households with SARS-CoV-2 cases in 2020
Creators: name: Mollan, Katie R.
name: Cassidy, Caitlin A.
name: Streeter, Gabrielle
name: Cerami, Carla
name: Lin, Feng-Chang
name: Basham, Christopher
name: Lin, Jessica T.
name: Rubinstein, Rebecca J.
name: Mei, Wenwen
Publisher: name: Frontiers Media S.A.
Year: 2023

description: Introduction Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) transmission frequently occurs within households, yet few studies describe which household contacts and household units are most likely to engage in transmission-interrupting behaviors. Methods We analyzed a COVID-19 prospective household transmission cohort in North Carolina (April to October 2020) to quantify changes in physical distancing behaviors among household contacts over 14 days. We evaluated which household contacts were most likely to ever mask at home and to ever share a bedroom with the index case between days 7–14. Results In the presence of a household COVID-19 infection, 24% of household contacts reported ever masking at home during the week before study entry. Masking in the home between days 7–14 was reported by 26% of household contacts and was more likely for participants who observed their household index case wearing a mask. Participants of color and participants in high-density households were more likely to mask at home. After adjusting for race/ethnicity, living density was not as clearly associated with masking. Symptomatic household contacts were more likely to share a bedroom with the index case. Working individuals and those with comorbidities avoided sharing a bedroom with the index case.DiscussionIn-home masking during household exposure to COVID-19 was infrequent in 2020. In light of the ongoing transmission of SARS-CoV-2, these findings underscore a need for health campaigns to increase the feasibility and social desirability of in-home masking among exposed household members. Joint messaging on social responsibility and prevention of breakthrough infections, reinfections, and long COVID-19 may help motivate transmission-interruption behaviors.
»Keine Menschheit ist dem Tode so ratlos gegenübergestanden wie die heutige«
Creators: name: Schatz, Oskar
Publisher: name: Internationale katholische Zeitschrift Communio
Year: 2022

description: Internationale katholische Zeitschrift Communio, Bd. 4 Nr. 6 (1975): Internationale katholische Zeitschrift Communio, Band 4, Heft 6
Additional file 1: of Differential neuro-immune patterns in two clinically relevant murine models of multiple sclerosis
Creators: name: DiSano, Krista
name: Linzey, Michael
name: Royce, Darlene
name: Pachner, Andrew
name: Gilli, Francesca
Publisher: name: Figshare
Year: 2019
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: Table S1. Clinical and experimental characteristics of mice. Mice information. (DOCX 24 kb)
Conserved Subgroups and Developmental Regulation in the Monocot rop Gene Family
Creators: name: Christensen, T. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: Rop small GTPases are plant-specific signaling proteins with roles in pollen and vegetative cell growth, abscisic acid signal transduction, stress responses, and pathogen resistance. We have characterized the rop family in the monocots maize (Zea mays) and rice (Oryza sativa). The maize genome contains at least nine expressed rops, and the fully sequenced rice genome has seven. Based on phylogenetic analyses of all available Rops, the family can be subdivided into four groups that predate the divergence of monocots and dicots; at least three have been maintained in both lineages. However, the Rop family has evolved differently in the two lineages, with each exhibiting apparent expansion in different groups. These analyses, together with genetic mapping and identification of conserved non-coding sequences, predict orthology for specific rice and maize rops. We also identified consensus protein sequence elements specific to each Rop group. A survey of ROP-mRNA expression in maize, based on multiplex reverse transcriptase-polymerase chain reaction and a massively parallel signature sequencing database, showed significant spatial and temporal overlap of the nine transcripts, with high levels of all nine in tissues in which cells are actively dividing and expanding. However, only a subset of rops was highly expressed in mature leaves and pollen. Intriguingly, the grouping of maize rops based on hierarchical clustering of expression profiles was remarkably similar to that obtained by phylogenetic analysis. We hypothesize that the Rop groups represent classes with distinct functions, which are specified by the unique protein sequence elements in each group and by their distinct expression patterns.
Accumulation, inversion, and depletion layers in SrTiO$_3$
Creators: name: Reich, K. V.
name: Schecter, M.
name: Shklovskii, B. I.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We study potential and electron density depth profiles in accumulation, inversion and depletion layers in crystals with large and nonlinear dielectric response such as $\mathrm{SrTiO_3}$. We describe the lattice dielectric response using the Landau-Ginzburg free energy expansion. In accumulation and inversion layers we arrive at new nonlinear dependencies of the width $d$ of the electron gas on applied electric field $D_0$. Particularly important is the predicted electron density profile of accumulation layers (including the $\mathrm{LaAlO_3/SrTiO_3}$ interface) $n(x) \propto (x+d)^{-12/7}$, where $d \propto D_0^{-7/5}$ . We compare this profile with available data and find satifactory agreement. For a depletion layer we find an unconventional nonlinear dependence of capacitance on voltage. We also evaluate the role of spatial dispersion in the dielectric response by adding a gradient term to the Landau-Ginzburg free energy.
You complete me: tumor cell-myeloid cell nuclear fusion as a facilitator of organ-specific metastasis
Creators: name: Coleman, Michael F.
name: Hursting, Stephen D.
name: Cozzo, Alyssa J.
Publisher: name: Frontiers Media S.A.
Year: 2023

description: Every cancer genome is unique, resulting in potentially near infinite cancer cell phenotypes and an inability to predict clinical outcomes in most cases. Despite this profound genomic heterogeneity, many cancer types and subtypes display a non-random distribution of metastasis to distant organs, a phenomenon known as organotropism. Proposed factors in metastatic organotropism include hematogenous versus lymphatic dissemination, the circulation pattern of the tissue of origin, tumor-intrinsic factors, compatibility with established organ-specific niches, long-range induction of premetastatic niche formation, and so-called “prometastatic niches” that facilitate successful colonization of the secondary site following extravasation. To successfully complete the steps required for distant metastasis, cancer cells must evade immunosurveillance and survive in multiple new and hostile environments. Despite substantial advances in our understanding of the biology underlying malignancy, many of the mechanisms used by cancer cells to survive the metastatic journey remain a mystery. This review synthesizes the rapidly growing body of literature demonstrating the relevance of an unusual cell type known as “fusion hybrid” cells to many of the hallmarks of cancer, including tumor heterogeneity, metastatic conversion, survival in circulation, and metastatic organotropism. Whereas the concept of fusion between tumor cells and blood cells was initially proposed over a century ago, only recently have technological advancements allowed for detection of cells containing components of both immune and neoplastic cells within primary and metastatic lesions as well as among circulating malignant cells. Specifically, heterotypic fusion of cancer cells with monocytes and macrophages results in a highly heterogeneous population of hybrid daughter cells with enhanced malignant potential. Proposed mechanisms behind these findings include rapid, massive genome rearrangement during nuclear fusion and/or acquisition of monocyte/macrophage features such as migratory and invasive capability, immune privilege, immune cell trafficking and homing, and others. Rapid acquisition of these cellular traits may increase the likelihood of both escape from the primary tumor site and extravasation of hybrid cells at a secondary location that is amenable to colonization by that particular hybrid phenotype, providing a partial explanation for the patterns observed in some cancers with regard to sites of distant metastases.