cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of Identification and attribution of weekly periodic biases in global epidemiological time series data
Creators: name: Gallagher, Kit
name: Creswell, Richard
name: Gavaghan, David
name: Lambert, Ben
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 1
Enhancing the efficiency and stability of perovskite solar cells
Creators: name: Lin, Chieh-Ting
Publisher: name: Imperial College London
Year: 2019

description: Organic-inorganic hybrid perovskite materials have demonstrated their potential in photovoltaic application in recent years. Apart from the effort on further improving the power conversion efficiencies (PCEs) of perovskite solar cells (PSCs), the stability of PSCs remains a key concern for technological application. In this thesis, approaches of improving PCEs of PSCs, and enhancing the stability under environmental stresses, are investigated. The first results chapter investigates the improved oxygen induced photodegradation in inverted structure PSCs in comparison to conventional structure PSCs. The enhanced stability is attributed to PCBM passivation and slow oxygen diffusion kinetics in the inverted structure PSC. The second results chapter demonstrates that the addition of aminovaleric acid (AVA) in methylammonium lead iodide (MAPbI3) light absorber can effectively enhance the stability of unencapsulated PSC against oxygen induced photodegradation. The enhanced stability is also observed in glass/perovskite thin film, indicating the enhanced stability is not dependent on other interlayers but perovskite material itself. AVA is found to be located at the surface of perovskite lattice, binding to the surface defects, resulting in improved stability. The third results chapter shows that the use of bulky cation 1-naphthylmethylamine (NMA) as an additive in MAPbI3 and wider band gap perovskite (MAPbI1-xBrx)3 light absorbers can minimize the Voc losses in inverted structure PSC. The enhanced Voc results from NMA terminated at grain surface, passivating the traps and suppressing the non-radiative recombination. The forth results chapter investigates the power conversion efficiencies (PCEs) and stability of inverted structure PSCs with different sizes of amino acids additives in MAPbI3 light absorber, showing that the addition of smallest amino acid, glycine, can not only enhance Voc but also stability of inverted structure PSC. The last results chapter shows that employing bilayer Cu/Ag electrode can improve the operational stability of unencapsulated inverted structure PSC.
Inga acrocephala Steud.
Creators: name: Molino, Jean-François
name: Sabatier, Daniel
name: Grenand, Pierre
name: Engel, Julien
name: Frame, Dawn
name: Delprete, Piero G.
name: Fleury, Marie
name: Odonne, Guillaume
name: Davy, Damien
name: Lucas, Eve J.
name: Martin, Claire A.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Fabales
Fabaceae
Inga
Inga acrocephala

description: [814] Inga acrocephala Steud.
 Flora 26 (45): 759 [17 Dec. 1843] (Steudel 1843). — Feuilleea acrocephala (Steud.) Kuntze, Revis. Gen. Pl. 1: 187 [5 Nov. 1891] (Kuntze 1891).
 Inga brevipedicellata Harms, Repert. Spec. Nov. Regni Veg. 19: 62 (Harms 1923).
VERNACULAR NAMES. — Pa: miumiu-akamã-arib, miumiu-akamãaribinẽ• Wp: ɨnga pini, ɨnga u po’i • Nt: weko • Cr: pwa-sikré • Br: ingá.
 HERBARIUM DATA (FG). — 38 collections at CAY. Sel. exs.: M.-F. Prévost & D. Sabatier 2464.
INVENTORY DATA (FG). — 86 trees in 44 plots; Fmax <1 %; dbhinv = 70 cm.
description: Published as part of Molino, Jean-François, Sabatier, Daniel, Grenand, Pierre, Engel, Julien, Frame, Dawn, Delprete, Piero G., Fleury, Marie, Odonne, Guillaume, Davy, Damien, Lucas, Eve J. & Martin, Claire A., 2022, An annotated checklist of the tree species of French Guiana, including vernacular nomenclature, pp. 345-903 in Adansonia (3) (3) 44 (26) on pages 516-517, DOI: 10.5252/adansonia2022v44a26, http://zenodo.org/record/7458777
Blockchain and AI-Based Secure Digital Advertising System for Real- Time Targeting and Fraud Prevention in Social Media
Creators: name: Dhamone, Santosh Shivlal
Publisher: name: Zenodo
Year: 2024
Subjects: Blockchain, AI, Digital Advertising, Social Media

description: Blockchain technology is frequently praised as a revolutionary option forenhancing the existing highly centralized institutions in our economy, whereall physical and non-physical assets are exchanged. Blockchain technology,powered by computer science and engineering, is thought to revolutionizethe current system by utilizing distributed ledger technology. Thistechnology ensures data transparency, allowing anybody in the network toaccess and view the information. Blockchain technology's resilience allowsfor its application in the present advertising environment, which is currentlycentralized and controlled by multiple parties. Although blockchaintechnology has great potential, there is still a dearth of scholarly discourseconnecting it with advertising. This essay explores the existing obstaclesthat make the measurement of advertising effects ineffective and unreliablein the advertising ecosystem. We elucidate how blockchain technology mayimprove the advertising system by addressing issues such as datatransparency, customer privacy, and ad fraud. This enhancement will resultin a more reliable and trustworthy system, benefiting both the technicalaspects and the consumers.
Assembly cell for the manufacturing of flexible solar modules in building integrated photovoltaics
Creators: name: Blankemeyer, Sebastian
name: Schulte-Huxel, Henning
name: Wirtz, Wiebke
name: Raatz, Annika
Publisher: name: Amsterdam [u.a.] : Elsevier
Year: 2024
Subjects: subject: flexible production cell
subject: gripper developement
subject: photovoltaic
subject: Konferenzschrift
subject: Dewey Decimal Classification::600 | Technik
subject: Dewey Decimal Classification::600 | Technik::670 | Industrielle und handwerkliche Fertigung

description: The current use of photovoltaics is often limited to the utilization of roof surfaces or ground-mounted systems. In particular, building integrated photovoltaics (BIPV) have enormous potential to make energy production more sustainable, because the energy is generated where it is used. However, most of these modules either do not meet the aesthetic requirements of the architects as well as the building owner or are uneconomical, since visually appealing building-integrated PV modules cost several times more than standard modules. In this article, an approach for a (semi) automated assembly line that allows geometry- and material-flexible manufacturing of PV modules is presented. The challenges in automating the flexible manufacturing processes include mainly the handling of limp components and the complexity of geometry variability. Appropriate gripper systems are required to ensure safe and reliable handling of the components. A gripper developed in this article offers the ability to flexibly deposit solar strings. Preliminary tests show that 66% of all conducted trials meet the accuracy requirements.
MOESM2 of Bursopentin (BP5) induces G1 phase cell cycle arrest and endoplasmic reticulum stress/mitochondria-mediated caspase-dependent apoptosis in human colon cancer HCT116 cells
Creators: name: Li, Jing
name: Li, Tian-xiang
name: Ma, Yao
name: Zhang, Yong
name: Li, De-yuan
name: Xu, Hai-rong
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Additional file 2: Figure S2. BP5 arrested cell cycle at G1 phase in HT29 and SW620 cells.
Visualization of higher-order topological insulating phases in two-dimensional dielectric photonic crystals
Creators: name: Xie, Bi-Ye
name: Su, Guang-Xu
name: Wang, Hong-Fei
name: Su, Hai
name: Shen, Xiao-Peng
name: Zhan, Peng
name: Lu, Ming-Hui
name: Wang, Zhen-Lin
name: Chen, Yan-Feng
Publisher: name: arXiv
Year: 2018
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The studies of topological phases of matter have been extended from condensed matter physics to photonic systems, resulting in fascinating designs of robust photonic devices. Recently, higher-order topological insulators (HOTIs) have been investigated as a novel topological phase of matter beyond the conventional bulk-boundary correspondence. Previous studies of HOTIs have been mainly focused on the topological multipole systems with negative coupling between lattice sites. Here we experimentally demonstrate that second-order topological insulating phases without negative coupling can be realized in two-dimensional dielectric photonic crystals (PCs). We visualize both one-dimensional topological edge states and zero-dimensional topological corner states by using near-field scanning technique. To characterize the topological properties of PCs, we define a novel topological invariant based on the bulk polarizations. Our findings open new research frontiers for searching HOTIs in dielectric PCs and provide a new mechanism for light-manipulating in a hierarchical way.
description: 23 pages, 4 figures
Inga alata Benoist
Creators: name: Molino, Jean-François
name: Sabatier, Daniel
name: Grenand, Pierre
name: Engel, Julien
name: Frame, Dawn
name: Delprete, Piero G.
name: Fleury, Marie
name: Odonne, Guillaume
name: Davy, Damien
name: Lucas, Eve J.
name: Martin, Claire A.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Fabales
Fabaceae
Inga
Inga alata

description: [815] Inga alata Benoist
 Bull. Mus. Natl. Hist. Nat. 27: 198 (Benoist 1921).
VERNACULAR NAMES. — Pa: avukun • Wp:ɨnga masulapa, masulapa • Cr: pwa-sikré • Br: ingá.
 HERBARIUM DATA (FG). — 28 collections at CAY. Sel. exs.: E.M. Mélinon 8a, 1845 (holo-, P[P01818410]; iso-, P[P01818411, P01818412]).
INVENTORY DATA (FG). — 29 trees in 18 plots; Fmax <1 %; dbhinv = 73 cm.
description: Published as part of Molino, Jean-François, Sabatier, Daniel, Grenand, Pierre, Engel, Julien, Frame, Dawn, Delprete, Piero G., Fleury, Marie, Odonne, Guillaume, Davy, Damien, Lucas, Eve J. & Martin, Claire A., 2022, An annotated checklist of the tree species of French Guiana, including vernacular nomenclature, pp. 345-903 in Adansonia (3) (3) 44 (26) on page 517, DOI: 10.5252/adansonia2022v44a26, http://zenodo.org/record/7458777
The i²Snake robot for endoscopic surgery
Creators: name: Berthet-Rayne, Pierre Tom Remy Raoul
Publisher: name: Imperial College London
Year: 2019

description: Minimally invasive surgery and more specifically endoscopic surgery is a surgical technique aiming to improve patient treatment and recovery by using natural orifices rather than incisions. However, this is at the cost of increased complexity for the surgeon and limits the number of procedures that can be performed. The recent introduction of robotic technology in the operating room has allowed to overcome most of the challenges faced during minimally invasive surgery, but further research needs to be done to develop robotic endoscopy. This thesis introduces a novel endoscopic robot called the i²Snake, an acronym for intuitive, imaging, sensing, navigated, and kinetically enhanced. The i²Snake is a snake-like robot with a fully actuated body and four instrument channels: 1x for a camera with light, 2x for a pair of robotic instruments and 1x for suction/irrigation. Several aspects of the design and control of the system are tackled in this thesis. Firstly, the state-of-the-art in medical robotics is studied in detail to determine the current trends and identify the existing gaps and needs for such robotic platforms. This is followed by a chapter on the mechanical design of the i²Snake. The design proposes an optimized rolling-joint to improve stability and joint range. The robot also uses a novel tendon routing to minimize cross-talk between joints and to allow formation of complex configurations such as S-shapes. The third chapter focuses on the design of the robotic instruments. This is accomplished by using recorded surgical trajectories combined with a genetic algorithm to automatically design an optimized pair of instruments. The fourth and fifth chapters focus on teleoperation and navigation to ensure intuitive full-body shape control and navigation. Finally, the last chapter discusses the operating room ergonomics and introduces novel features for safe and intuitive manipulation of the robotic platform.
First-order transition in small-world networks
Creators: name: de Menezes, M. Argollo
name: Moukarzel, C.
name: Penna, T. J. P.
Publisher: name: arXiv
Year: 1999
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: The small-world transition is a first-order transition at zero density $p$ of shortcuts, whereby the normalized shortest-path distance undergoes a discontinuity in the thermodynamic limit. On finite systems the apparent transition is shifted by $Δp \sim L^{-d}$. Equivalently a ``persistence size'' $L^* \sim p^{-1/d}$ can be defined in connection with finite-size effects. Assuming $L^* \sim p^{-τ}$, simple rescaling arguments imply that $τ=1/d$. We confirm this result by extensive numerical simulation in one to four dimensions, and argue that $τ=1/d$ implies that this transition is first-order.
description: 4 pages, 3 figures, To appear in Europhysics Letters
Tracking the cellular uptake and phototoxicity of Ru(ii)-polypyridyl-1,8-naphthalimide Tröger's base conjugates
Creators: name: Bright, Sandra
A.
name: Erby, MariaLuisa
name: Poynton, Fergus E.
name: Monteyne, Daniel
name: Pérez-Morga, David
name: Gunnlaugsson, Thorfinnur
name: Williams, D. Clive
name: Elmes, Robert B. P.
Publisher: name: University of Limerick
Year: 2024
Subjects: classificationCode: 34
subject: Chemical sciences
subject: FOS: Chemical sciences

description: Ruthenium(II) complexes are attracting significant research attention as a promising class of photo-sensitizers (PSs) in photodynamic therapy (PDT). Having previously reported the synthesis of two novel Ru(II)-polypyridyl-1,8-naphthalimide Tro¨ger’s base compounds 1 and 2 with interesting photophysical properties, where the emission from either the Ru(II) polypyridyl centres or the naphthalimide moieties could be used to monitor binding to nucleic acids, we sought to use these compounds to investigate further and in more detail their biological profiling, which included unravelling their mechanism of cellular uptake, cellular trafficking and cellular responses to photoexcitation. Here we demonstrate that these compounds undergo rapid time dependent uptake in HeLa cells that involved energy dependent, caveolae and lipid raft-dependent mediated endocytosis, as demonstrated by confocal imaging, and transmission and scanning electron microscopy. Following endocytosis, both compounds were shown to localise to mostly lysosomal and Golgi apparatus compartments with some accumulation in mitochondria but no localisation was found to the nucleus. Upon photoactivation, the compounds increased ROS production and induced ROS-dependent apoptotic cell death. The photo-activated compounds subsequently induced DNA damage and altered tubulin, but not actin structures, which was likely to be an indirect effect of ROS production and induced apoptosis. Furthermore, by changing the concentration of the compounds or the laser used to illuminate the cells, the mechanism of cell death could be changed from apoptosis to necrosis. This is the first detailed biological study of Ru(II)-polypyridyl Tro¨ger’s bases and clearly suggests caveolae-dependent endocytosis is responsible for cell uptake – this may also explain the lack of nuclear uptake for these compounds and similar results observed for other Ru(II)-polypyridyl complexes. These conjugates are potential candidates for further development as PDT agents and may also be useful in mechanistic studies on cell uptake and trafficking.
Dynamics of the water-energy nexuses of Mumbai and London
Creators: name: De Stercke, Simon
Publisher: name: Imperial College London
Year: 2019

description: The urban water-energy nexus sits at the intersection of three global challenges: urbanisation, global freshwater scarcity, and climate change caused by energy use. The concept recognises the various interactions between water and energy systems at all stages, as well as the concentration of service demand in cities which drives most of global resource use. Research indicates that end use is the largest component of the nexus, both in terms of energy and of water. However, the interactions on the level of energy and water supply and wastewater have received most attention, part of the reason being the difficulty in characterising end use. There is still a lack of knowledge about the end-use linkages in cities, and about their role in urban dynamics. This research elucidates the urban water-energy nexus with a conceptualisation, a comprehensive appraisal of its components and an investigation of its dynamics. To this end, I developed a system dynamics model for London as a case study, and expanded on it for Mumbai as an example of a city in the Global South for which research of this kind has been thin. The models have at their core a novel end-use structure with bidirectional water-energy interactions by service, and also represent population dynamics, the urban water system, environmental constraints and a tax based climate policy. The results show that end-use interactions play an important role in determining future resource consumption. In London, disregarding them in planning may lock in energy-intensive water supply, while in Mumbai it may perpetuate intermittent water supply. More applications of this kind are needed for global conclusions, and I provide methods for extending the model to the diversity of cities. This work ultimately implies that the end-use water-energy interactions should be more prominent in urban sustainability debates and planning.
Inga alba Willd.
Creators: name: Molino, Jean-François
name: Sabatier, Daniel
name: Grenand, Pierre
name: Engel, Julien
name: Frame, Dawn
name: Delprete, Piero G.
name: Fleury, Marie
name: Odonne, Guillaume
name: Davy, Damien
name: Lucas, Eve J.
name: Martin, Claire A.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Fabales
Fabaceae
Inga
Inga alba

description: [816] Inga alba (Sw.) Willd.
 Sp. Pl., ed. 4 4 (2): 1013 [Apr. 1806] (Willdenow 1806). — Mimosa alba Sw., Prodr. [Swartz] 85 [20 Jun.-29 July 1788] (Swartz 1788). — Feuilleea alba (Sw.) Kuntze, Revis. Gen. Pl. 1: 187 [5 Nov. 1891] (Kuntze 1891).
 Inga fraxinea Willd., Sp. Pl., ed. 4 4 (2): 1019 [Apr. 1806] (Willdenow 1806). — Mimosa fraxinea (Willd.) Poir., Encycl. [J. Lamarck et al.] Suppl. 1: 44 [3 Sep. 1810] (Poiret 1810).
 Mimosa alba Vahl, Eclog. Amer. 3: 31 (Vahl 1807), nom. illeg. hom., non Sw. (Swartz 1788).
 Inga thyrsoidea Desv., J. Bot. Agric. 3: 71 (Desvaux 1814).
 Inga aggregata G.Don, Gen. Hist. 2: 391 [Oct. 1832] (Don 1832). — Feuilleea aggregata (G.Don) Kuntze, Revis. Gen. Pl. 1: 187 [5 Nov. 1891] (Kuntze 1891).
 Inga spruceana Benth., Hooker’s J. Bot. Kew Gard. Misc. 2: 239 (Bentham 1850).
 Inga parviflora Sagot ex Benth., Trans. Linn. Soc. London 30 (3): 602 [10 Apr. 1875] (Bentham 1875), nom. nud. pro syn.
 Inga carachensis Pittier, Arb. Arbust. Venez. 9-10: 106 [Dec. 1929] (Pittier 1929).
 Inga altissima Ducke, Arch. Inst. Biol. Veg. 4 (1): 4 [June 1938] (Ducke 1938).
 NOTE. — Hyperdominant in Amazonia (ter Steege et al. 2020).
VERNACULAR NAMES. — Pa: avukun, avukun-duwõ • Ka: abuluguni, apulukuni • Te: pulukuni • Wp: ɨnga sisi, ɨnga u, sisi, sisi sĩ• Wn: apulukun • Nt: kooponyo, lebi weko • Cr: bougouni, bwa-pagód • Fr: bougouni • Br: ingá-branca, ingá-xixica.
 HERBARIUM DATA (FG). — 95 collections at CAY. Sel. exs.: J.P.B. von Rohr s.n. (type BM [BM000541200]).
INVENTORY DATA (FG). — 228 trees in 104 plots; Fmax = 3.6 %; dbhinv = 100 cm.
description: Published as part of Molino, Jean-François, Sabatier, Daniel, Grenand, Pierre, Engel, Julien, Frame, Dawn, Delprete, Piero G., Fleury, Marie, Odonne, Guillaume, Davy, Damien, Lucas, Eve J. & Martin, Claire A., 2022, An annotated checklist of the tree species of French Guiana, including vernacular nomenclature, pp. 345-903 in Adansonia (3) (3) 44 (26) on page 517, DOI: 10.5252/adansonia2022v44a26, http://zenodo.org/record/7458777
Lorlatinib as a first-line treatment of adult patients with anaplastic lymphoma kinase-positive advanced non-small cell lung cancer: Α cost-effectiveness analysis in Greece
Creators: name: Gourzoulidis, George
name: Zisimopoulou, Oresteia
name: Liavas, Andrianos
name: Tzanetakos, Charalampos
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Plant Biology
subject: FOS: Biological sciences

description: To evaluate the cost-effectiveness of lorlatinib compared to 1st generation anaplastic lymphoma kinase (ALK) TKI crizotinib, and 2nd generation TKIs alectinib and brigatinib, for previously untreated patients with ALK+ advanced Non-Small Cell Lung Cancer (aNSCLC). A partitioned survival model was locally adapted from a Greek payer perspective over a lifetime horizon. Clinical, safety and utility data were extracted from literature. Direct medical costs reflecting the year 2023 were included in the analysis (€). Model outcomes were patients’ life years (LYs), quality-adjusted life years (QALYs), total costs and incremental cost-effectiveness ratios (ICERs). Total cost per patient with lorlatinib, alectinib, crizotinib, and brigatinib was estimated to be €188,205, €183,343, €75,028, and €145,454 respectively. Lorlatinib appeared to yield more LYs and QALYs gained versus alectinib, crizotinib, and brigatinib. Hence, lorlatinib resulted in ICERs of €4,315 per LY gained and €4,422 per QALY gained compared to alectinib, €34,032 per LY gained and €48,256 per QALY gained versus crizotinib and €16,587 per LY gained and €26,271 per QALY gained compared to brigatinib. Lorlatinib provides substantial clinical benefit and appears to be a cost – effective treatment option compared to 1st and 2nd generation TKIs for previously untreated patients with ALK+ aNCSLC in Greece.
The Chemical Evolution of Carbon, Nitrogen, and Oxygen in Metal-Poor Dwarf Galaxies
Creators: name: Berg, Danielle A.
name: Erb, Dawn K.
name: Henry, Richard B. C.
name: Skillman, Evan D.
name: McQuinn, Kristen B. W.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Ultraviolet nebular emission lines are important for understanding the time evolution and nucleosynthetic origins of their associated elements, but the underlying trends of their relative abundances are unclear. We present UV spectroscopy of 20 nearby low-metallicity, high-ionization dwarf galaxies obtained using the Hubble Space Telescope. Building upon previous studies, we analyze the C/O relationship for a combined sample of 40 galaxies with significant detections of the UV O+2/C+2 collisionally-excited lines and direct-method oxygen abundance measurements. Using new analytic carbon ionization correction factor relationships, we confirm the flat trend in C/O versus O/H observed for local metal-poor galaxies. We find an average log(C/O) = -0.71 with an intrinsic dispersion of σ = 0.17 dex. The C/N ratio also appears to be constant at log(C/N) = 0.75, plus significant scatter (σ = 0.20 dex), with the result that carbon and nitrogen show similar evolutionary trends. This large and real scatter in C/O over a large range in O/H implies that measuring the UV C and O emission lines alone does not provide a reliable indicator of the O/H abundance. By modeling the chemical evolution of C, N, and O of individual targets, we find that the C/O ratio is very sensitive to both the detailed star formation history and to supernova feedback. Longer burst durations and lower star formation efficiencies correspond to low C/O ratios, while the escape of oxygen atoms in supernovae winds produces decreased effective oxygen yields and larger C/O ratios. Further, a declining C/O relationship is seen with increasing baryonic mass due to increasing effective oxygen yields.
description: 30 pages, 13 figures, 13 tables, resubmitted after initial referee comments
Immunomodulation of ovarian cancer by DNMTi and expression of endogenous retroviruses
Creators: name: Natoli, Marina
Publisher: name: Imperial College London
Year: 2019

description: Immunotherapeutic strategies for ovarian cancer (OC) patients have so far failed to show any benefit in clinical trials. Novel combination strategies are being developed to enhance immune function in these patients by overcoming immunosuppressive mechanisms present within the ovarian tumour microenvironment. Epigenetic modifying agents, such as DNA methyltransferase inhibitors (DNMTi), have shown some promise in synergising with immunotherapy in OC in preclinical studies and early clinical trials. Furthermore, a role for DNMTi-induced endogenous retrovirus (ERV) expression in enhancing response to immunotherapy has recently been suggested. Here, DNMTi-driven immunomodulation was investigated using in vitro models of ovarian cancer and immune cell interactions. The effect of DNMTi treatment of OC cell lines on transcription of ERVs was also investigated, together with the prognostic and immunomodulatory consequences of baseline ERV expression in OC cell lines and ovarian tumours. DNMTi treatment of OC cell lines was shown to enhance activation of previously unstimulated immune cells as well as killing of tumour cells by activated effector immune cells. Transcriptomic analysis revealed upregulation of gene and ERV expression in OC cell lines, following DNMTi treatment. Particularly, an enrichment for adaptive and innate immunomodulatory genes was observed in DNMTi-treated cell lines, compared to vehicle-treated controls. Analysis of baseline gene and ERV expression in two OC cell lines revealed transcriptional differences, including distinct levels of ERV expression, which may affect each OC cell line’s response to DNMTi and immune cell attack. Interrogation of transcriptomic data from OC samples from TCGA revealed that ERV expression defines subsets of OC patients. Moreover, expression of single ERV repeats was associated with patient prognosis and significantly correlated with expression of immune genes and signatures. Finally, an ERV prognostic model was generated to predict patient prognosis, based on expression of selected ERVs. These findings highlight a role for DNMTi treatment of OC cells in enhancing immune activation via induction of ERVs and immunomodulatory genes as well as the potential for baseline ERV expression in OC to inform patient prognosis and influence local tumour immunogenicity.
Additional file 1 of Cerebral oxygenation and hemodynamic changes during ephedrine and phenylephrine administration for transient intraoperative hypotension in patients undergoing major abdominal surgery: a randomized controlled trial
Creators: name: Li, Xueyan
name: Zheng, Yijun
name: Zhang, Jun
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Mental Health

description: Supplementary Material 1
title: Desectarianization in Lebanon
title: structural impediments and the agency of religious leaders
titleType: Subtitle
Creators: name: Ghazal, Elias
Publisher: name: Lancaster University
Year: 2024

description: This thesis examines the multifaceted issue of sectarianism and its
 negative effects on political stability, economic development, and social
 cohesion in the country. Using a constructivist framework, this thesis
 aims to contribute to the existing literature on desectarianization by
 analyzing the specific context of Lebanon. It identifies three categories
 of structures that facilitate sectarianization and impede the process of
 desectarianization: domestic structures, geopolitical structures, and
 normative structures. Domestic structures involve formal and informal
 domestic systems that privilege sectarian identities and patronage
 networks in Lebanon. Geopolitical structures refer to regional dynamics
 that deepen sectarian divisions. Normative structures encompass social
 constructs, like mistrust and the absence of inclusive citizenship
 education, which hinder effective desectarianization. The thesis explores
 the capacity of religious leaders to act as desectarianization actors to
 circumvent those structural impediments. Special focus is given to the
 agency of Shiite clergymen in the Lebanese context.
Clusters and Fluctuations at Mean-Field Critical Points and Spinodals
Creators: name: Klein, W.
name: Gould, Harvey
name: Tobochnik, J.
name: Alexander, F. J.
name: Anghel, M.
name: Johnson, Gregory
Publisher: name: arXiv
Year: 2000
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We show that the structure of the fluctuations close to spinodals and mean-field critical points is qualitatively different than the structure close to non-mean-field critical points. This difference has important implications for many areas including the formation of glasses in supercooled liquids. In particular, the divergence of the measured static structure function in near-mean-field systems close to the glass transition is suppressed relative to the mean-field prediction in systems for which a spatial symmetry is broken.
description: 5 pages, 1 figure
Forecasting the Arrival Time of Coronal Mass Ejections: Analysis of the CCMC CME Scoreboard
Creators: name: Riley, Pete
name: Mays, Leila
name: Andries, Jesse
name: Amerstorfer, Tanja
name: Biesecker, Douglas
name: Delouille, Veronique
name: Dumbovic, Mateja
name: Feng, Xueshang
name: Henley, Edmund
name: Linker, Jon A.
name: Mostl, Christian
name: Nunez, Marlon
name: Pizzo, Vic
name: Temmer, Manuela
name: Tobiska, W. K.
name: Verbeke, C.
name: West, Matthew J
name: Zhao, Xinhua
Publisher: name: arXiv
Year: 2018
Subjects: subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: Accurate forecasting of the properties of coronal mass ejections as they approach Earth is now recognized as an important strategic objective for both NOAA and NASA. The time of arrival of such events is a key parameter, one that had been anticipated to be relatively straightforward to constrain. In this study, we analyze forecasts submitted to the Community Coordinated Modeling Center (CCMC) at NASA's Goddard Space Flight Center over the last six years to answer the following questions: (1) How well do these models forecast the arrival time of CME-driven shocks? (2) What are the uncertainties associated with these forecasts? (3) Which model(s) perform best? (4) Have the models become more accurate during the past six years? We analyze all forecasts made by 32 models from 2013 through mid 2018, and additionally focus on 28 events all of which were forecasted by six models. We find that the models are generally able to predict CME-shock arrival times -- in an average sense -- to within 10 hours, but with standard deviations often exceeding 20 hours. The best performers, on the other hand, maintained a mean error (bias) of -1 hour, a mean absolute error of 13 hours, and a precision (s.d.) of 15 hours. Finally, there is no evidence that the forecasts have become more accurate during this interval. We discuss the intrinsic simplifications of the various models analyzed, the limitations of this investigation, and suggest possible paths to improve these forecasts in the future.
Cost-effectiveness analysis of dupilumab versus omalizumab, mepolizumab, and benralizumab added to the standard of care in adults with severe asthma in Colombia
Creators: name: Ali, Abraham
name: García, Elizabeth
name: Torres-Duque, Carlos A
name: Rey, Diana
name: Botero, Laura
name: Saenz, Stid
name: Avila, Maria Paula
name: Mazo, Elizabeth
name: Londoño, Sergio
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Medicine
Pharmacology
Science Policy

description: Cost-effectiveness studies evaluate health technologies and help choose treatments. The current study compared dupilumab to omalizumab, mepolizumab, and benralizumab in Colombian adults with severe uncontrolled type 2 asthma. Over a 5-year period, a Markov model was utilized to assess the costs of biological treatments and management of exacerbations, comparing various doses of exacerbations, comparing various doses of dupilumab, omalizumab, mepolizumab, and benralizumab as add-on treatments. It included a 5% annual discount rate per local HTA, and set willingness-to-pay at three times GDP per capita per quality-adjusted life year (QALY) in Colombia. Dupilumab (200 mg) exhibited greater QALYs and reduced overall costs compared to mepolizumab (100 mg), benralizumab (30 mg), and omalizumab (450 mg and 600 mg), with the incremental cost-effectiveness ratio (ICER) per QALYgained being -$5.429, -$6.269, -$196.567 and -$991.007, respectively. Dupilumab had greater QALYs and costs versus omalizumab 300 mg (ICERof $200.653 per QALY, above the willingness-to-pay threshold of 3 × GDP per capita). Sensitivity analyses were consistent with base case results. Dupilumab 200 mg was strongly dominant versus omalizumab 450 mg and 600 mg, mepolizumab 100 mg, and benralizumab 30 mg; however, cost-effectiveness was not demonstrated versus omalizumab 300 mg. These results could assist healthcare professionals in choosing an appropriate biologic for treating severe type 2 asthma.
Inga auristellae Harms
Creators: name: Molino, Jean-François
name: Sabatier, Daniel
name: Grenand, Pierre
name: Engel, Julien
name: Frame, Dawn
name: Delprete, Piero G.
name: Fleury, Marie
name: Odonne, Guillaume
name: Davy, Damien
name: Lucas, Eve J.
name: Martin, Claire A.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Fabales
Fabaceae
Inga
Inga auristellae

description: [817] Inga auristellae Harms
 Notizbl. Königl. Bot. Gart. Berlin 6: 298 [30 June 1915] (Harms 1915).
VERNACULAR NAMES. — Wp: ɨnga sili • Cr: pwa-sikré.
 HERBARIUM DATA (FG). — 35 collections at CAY. Sel. exs.: D. Sabatier & M.-F. Prévost 4282.
INVENTORY DATA (FG). — 11 trees in 10 plots; Fmax <1 %; dbhinv = 33.1 cm.
description: Published as part of Molino, Jean-François, Sabatier, Daniel, Grenand, Pierre, Engel, Julien, Frame, Dawn, Delprete, Piero G., Fleury, Marie, Odonne, Guillaume, Davy, Damien, Lucas, Eve J. & Martin, Claire A., 2022, An annotated checklist of the tree species of French Guiana, including vernacular nomenclature, pp. 345-903 in Adansonia (3) (3) 44 (26) on page 517, DOI: 10.5252/adansonia2022v44a26, http://zenodo.org/record/7458777
Trifarotene phase 3 supplemental information
Creators: name: Alio, Alessandra
name: Tan, Jerry
name: Thiboutot, Diane M.
Publisher: name: figshare
Year: 2019
Subjects: subject: 110304 Dermatology
subject: FOS: Clinical medicine

description: Supplemental information for trifarotene phase III publication in Journal of American Academy of Dermatology
Report on Existing Semantic Interoperability
Creators: name: Leary, Rebecca
name: Hedley, Victoria
name: Kalra, Dipak
name: Handel, Melissa
name: Robinson, Peter
name: Cornet, Ronald
name: Owen, John
name: Straub, Volker
Publisher: name: Zenodo
Year: 2020

description: The concept of semantic interoperability is becoming increasingly important in the health and research fields, particularly in areas where data is scarce and precious such as rare and paediatric diseases. As Information Technology plays an ever increasing role in both healthcare and clinical research, it can act as an enabler to more efficient and standardized collection of various types of data, but also, in the right circumstances, can facilitate the sharing, pooling or querying of data. Myriad software solutions exist to capture and process health and research-relevant data - to allow these disparate eHealth and eResearch systems and tools to ‘speak’ to one another (without the need for very time-consuming and costly human data integration activity), some degree of interoperability is necessary
Fiscal analysis of the pediatric immunization program in Belgium applying a lifetime government perspective framework
Creators: name: Kotsopoulos, Nikos
name: Bento-Abreu, André
name: Bencina, Goran
name: Connolly, Mark P.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: A public economic framework was used to explore lifetime government costs and benefits in relation to the Pediatric Immunization Program (PIP) in Belgium based on cases and deaths averted. To estimate changes in net government revenue, we developed a decision-analytic model that quantifies lifetime tax revenues and transfers based on changes in morbidity and mortality arising from Belgium’s Pediatric Immunization Program (PIP). The model considered differences in incidence rates with vaccines included in Belgium’s PIP: compared with the pre-vaccine era. Changes in deaths and comorbid conditions attributed to PIP on the Belgium 2020 birth cohort were used to estimate gross lifetime earnings changes, tax revenue gains attributed to averted morbidity and mortality avoidance, disability transfer cost savings, and averted special education costs associated with each vaccine. Vaccinating a single birth cohort according to the PIP gives rise to fiscal gains of €56 million in averted tax revenue loss, €8 million disability savings, and €6 million special education cost-savings. Based on the costs of implementing the PIP, we estimate the fiscal benefit–cost ratio (fBCR) of €2.2 investment return for the government from every €1 invested excluding longevity costs. Reducing vaccine-preventable conditions generates tax revenue for the government, providing fiscal justification for sustained immunization investments.
Triple sign reversal of Hall effect in HgBa_{2}CaCu_{2}O_{6} thin films after heavy-ion irradiations
Creators: name: Kang, W. N.
name: Kang, B. W.
name: Chen, Q. Y.
name: Wu, J. Z.
name: Bai, Y.
name: Chu, W. K.
name: Christen, D. K.
name: Kerchner, R.
name: Lee, Sung-Ik
Publisher: name: arXiv
Year: 1999
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Triple sign reversal in the mixed-state Hall effect has been observed for the first time in ion-irradiated HgBa_{2}CaCu_{2}O_{6} thin films. The negative dip at the third sign reversal is more pronounced for higher fields, which is opposite to the case of the first sign reversal near T_c in most high-T_c superconductors. These observations can be explained by a recent prediction in which the third sign reversal is attributed to the energy derivative of the density of states and to a temperature-dependent function related to the superconducting energy gap. These contributions prominently appear in cases where the mean free path is significantly decreased, such as our case of ion-irradiated thin films.
description: 4 pages, 3 eps figures, submitted Phys. Rev. Lett
Additional file 2 of Cerebral oxygenation and hemodynamic changes during ephedrine and phenylephrine administration for transient intraoperative hypotension in patients undergoing major abdominal surgery: a randomized controlled trial
Creators: name: Li, Xueyan
name: Zheng, Yijun
name: Zhang, Jun
Publisher: name: figshare
Year: 2025
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Mental Health

description: Supplementary Material 2
Medeopteryx clipeata Ballantyne & Lambkin 2013, sp. nov.
Creators: name: Ballantyne, Lesley A.
name: Lambkin, Christine L.
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Lampyridae
Medeopteryx
Medeopteryx clipeata

description: Medeopteryx clipeata sp. nov. [Figs 147–153] Holotype. Male. NEW GUINEA: Ruka, 9 m, 12.viii.1964, H. Clissold, light trap (BPBM). Paratypes (42). Same locality as holotype, 18 males. 8.51S, 143.11E, Western District, Oriomo River, 3 m, light trap, H. Clissold, 1.viii.1964, 6 males; 4.viii.1964, 2 males; 6.viii.1964, 14 males; 16.viii.1964, 2 males (BPBM). Diagnosis. Pronotum orange, elytra dark brown; distinguished from all other Medeopteryx by the loss of the anteromedian area of LO in V7 (Fig. 147). Female and larva unknown. Male. 6.5–7.0 mm long. Colour: pronotum, MS and MN orange; elytra dark brown (under direct microscopic examination the illumination makes the elytral pubescence appear golden thus masking the base elytral colour); head dark brown with a median triangular area on vertex dingy orange; labrum orange; antennae and palpi dark brown; ventral aspect of thorax and abdominal V2–4 and basal fourth of V5 light brown (ventral surface of metathorax sometimes dingy orange); legs orange except tibiae 1, and tarsi of all legs dark brown; V6 and 7 pale cream in area of LO, yellowish elsewhere; all tergites pale brown; dorsally reflexed margins of Vs cream. Pronotum: 1.0– 1.2 mm long; 1.4–1.6 mm wide; subparallel sided; punctures small, shallow, separated by their width. Head: moderately depressed between eyes; GHW 1.2–1.3 mm; SIW 0.3 mm; ASD subequal to ASW. Antennae elongate, slender, FS 7–9 not obviously shorter than remaining FS. Elytron (Fig. 153): apex rounded. LO (Figs 147, 149, 151): retracted from anteromedian area of V7 (the cuticular area extending from the MPP of V7 attaches in this area, as do longitudinal muscles visible through cuticle; Fig. 150). Abdomen: MPP projecting posteriorly a little beyond PLP and projecting ventrally (Fig. 147, 149, 151), terminating in fine paired projections. T8: ventral surface with lateral ridges and finely pointed, forwardly projecting flanges. Aedeagus: (Fig. 152) with apex of median lobe pointed, and bearing an acute ridge on dorsal surface level with the incurved tips of LL. Remarks. The specific name clipeata (clipeatus, a um, Latin = bearing a shield) refers to the shield shaped area in V7 devoid of LO. This new species superficially resembles M. antennata. The functional significance of the modifications to V7 and the reduction in LO area are discussed subsequently.
description: Published as part of Ballantyne, Lesley A. & Lambkin, Christine L., 2013, Systematics and Phylogenetics of Indo-Pacific Luciolinae Fireflies (Coleoptera: Lampyridae) and the Description of new Genera, pp. 1-162 in Zootaxa 3653 (1) on page 85, DOI: 10.11646/zootaxa.3653.1.1, http://zenodo.org/record/5265340
Modeling and Simulation of Multi-Lane Traffic Flow
Creators: name: Helbing, Dirk
Publisher: name: arXiv
Year: 1998
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: A most important aspect in the field of traffic modeling is the simulation of bottleneck situations. For their realistic description a macroscopic multi-lane model for uni-directional freeways including acceleration, deceleration, velocity fluctuations, overtaking and lane-changing maneuvers is systematically deduced from a gas-kinetic (Boltzmann-like) approach. The resulting equations contain corrections with respect to previous models. For efficient computer simulations, a reduced model delineating the coarse-grained temporal behavior is derived and applied to bottleneck situations.
description: For related work see http://www.theo2.physik.uni-stuttgart.de/helbing.html
Maximal index automorphisms of free groups with no attracting fixed points on the boundary are Dehn twists
Creators: name: Martino, Armando
Publisher: name: arXiv
Year: 2001
Subjects: subject: Group Theory (math.GR)
subject: FOS: Mathematics
subject: 20E05, 20E36

description: In this paper we define a quantity called the rank of an outer automorphism of a free group which is the same as the index introduced in [D. Gaboriau, A. Jaeger, G. Levitt and M. Lustig, `An index for counting fixed points for automorphisms of free groups', Duke Math. J. 93 (1998) 425-452] without the count of fixed points on the boundary. We proceed to analyze outer automorphisms of maximal rank and obtain results analogous to those in [D.J. Collins and E. Turner, `An automorphism of a free group of finite rank with maximal rank fixed point subgroup fixes a primitive element', J. Pure and Applied Algebra 88 (1993) 43-49]. We also deduce that all such outer automorphisms can be represented by Dehn twists, thus proving the converse to a result in [M.M. Cohen and M. Lustig, `The conjugacy problem for Dehn twist automorphisms of free groups', Comment Math. Helv. 74 (1999) 179-200], and indicate a solution to the conjugacy problem when such automorphisms are given in terms of images of a basis, thus providing a moderate extension to the main theorem of Cohen and Lustig by somewhat different methods.
description: Published by Algebraic and Geometric Topology at http://www.maths.warwick.ac.uk/agt/AGTVol2/agt-2-36.abs.html
Assembling partial charges from fragments
Creators: name: Wang, Lily
Publisher: name: Zenodo
Year: 2021
Subjects: partial atomic charges
force field
molecular dynamics
am1bcc
openeye
openforcefield

description: Slides available at 10.5281/zenodo.4987086 . A group meeting update on my work investigating whether partial atomic charges for large molecules can be derived using the AM1BCC charge model from fragments of smaller molecules, as part of OpenForceField's push towards a new biopolymer force field. I outline how I use my package polymetrizer to combine input residues with each other so that each residue is within a local chemical environment, parametrize it with the small molecule force field Parsley, and combine parameters to create a residue-based force field. I note an unexpected bug where the atom ordering within the molecule affects the derived charges, confounding any metric I use to evaluate the quality of the charges generated, and ask for help.
description: Thank you to Jeff Wagner for your valuable feedback on an earlier draft of this talk.