Additional file 1 of A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry
Creators: name: Middha, Pooja
name: Wang, Xiaoliang
name: Behrens, Sabine
name: Bolla, Manjeet K.
name: Wang, Qin
name: Dennis, Joe
name: Michailidou, Kyriaki
name: Ahearn, Thomas U.
name: Andrulis, Irene L.
name: Anton-Culver, Hoda
name: Arndt, Volker
name: Aronson, Kristan J.
name: Auer, Paul L.
name: Augustinsson, Annelie
name: Baert, Thaïs
name: Freeman, Laura E. Beane
name: Becher, Heiko
name: Beckmann, Matthias W.
name: Benitez, Javier
name: Bojesen, Stig E.
name: Brauch, Hiltrud
name: Brenner, Hermann
name: Brooks-Wilson, Angela
name: Campa, Daniele
name: Canzian, Federico
name: Carracedo, Angel
name: Castelao, Jose E.
name: Chanock, Stephen J.
name: Chenevix-Trench, Georgia
name: Cordina-Duverger, Emilie
name: Couch, Fergus J.
name: Cox, Angela
name: Cross, Simon S.
name: Czene, Kamila
name: Dossus, Laure
name: Dugué, Pierre-Antoine
name: Eliassen, A. Heather
name: Eriksson, Mikael
name: Evans, D. Gareth
name: Fasching, Peter A.
name: Figueroa, Jonine D.
name: Fletcher, Olivia
name: Flyger, Henrik
name: Gabrielson, Marike
name: Gago-Dominguez, Manuela
name: Giles, Graham G.
name: González-Neira, Anna
name: Grassmann, Felix
name: Grundy, Anne
name: Guénel, Pascal
name: Haiman, Christopher A.
name: Håkansson, Niclas
name: Hall, Per
name: Hamann, Ute
name: Hankinson, Susan E.
name: Harkness, Elaine F.
name: Holleczek, Bernd
name: Hoppe, Reiner
name: Hopper, John L.
name: Houlston, Richard S.
name: Howell, Anthony
name: Hunter, David J.
name: Ingvar, Christian
name: Isaksson, Karolin
name: Jernström, Helena
name: John, Esther M.
name: Jones, Michael E.
name: Kaaks, Rudolf
name: Keeman, Renske
name: Kitahara, Cari M.
name: Ko, Yon-Dschun
name: Koutros, Stella
name: Kurian, Allison W.
name: Lacey, James V.
name: Lambrechts, Diether
name: Larson, Nicole L.
name: Larsson, Susanna
name: Le Marchand, Loic
name: Lejbkowicz, Flavio
name: Li, Shuai
name: Linet, Martha
name: Lissowska, Jolanta
name: Martinez, Maria Elena
name: Maurer, Tabea
name: Mulligan, Anna Marie
name: Mulot, Claire
name: Murphy, Rachel A.
name: Newman, William G.
name: Nielsen, Sune F.
name: Nordestgaard, Børge G.
name: Norman, Aaron
name: O’Brien, Katie M.
name: Olson, Janet E.
name: Patel, Alpa V.
name: Prentice, Ross
name: Rees-Punia, Erika
name: Rennert, Gad
name: Rhenius, Valerie
name: Ruddy, Kathryn J.
name: Sandler, Dale P.
name: Scott, Christopher G.
name: Shah, Mitul
name: Shu, Xiao-Ou
name: Smeets, Ann
name: Southey, Melissa C.
name: Stone, Jennifer
name: Tamimi, Rulla M.
name: Taylor, Jack A.
name: Teras, Lauren R.
name: Tomczyk, Katarzyna
name: Troester, Melissa A.
name: Truong, Thérèse
name: Vachon, Celine M.
name: Wang, Sophia S.
name: Weinberg, Clarice R.
name: Wildiers, Hans
name: Willett, Walter
name: Winham, Stacey J.
name: Wolk, Alicja
name: Yang, Xiaohong R.
name: Zamora, M. Pilar
name: Zheng, Wei
name: Ziogas, Argyrios
name: Dunning, Alison M.
name: Pharoah, Paul D. P.
name: García-Closas, Montserrat
name: Schmidt, Marjanka K.
name: Kraft, Peter
name: Milne, Roger L.
name: Lindström, Sara
name: Easton, Douglas F.
name: Chang-Claude, Jenny
Publisher: name: figshare
Year: 2024
Subjects: subject: Statistics
subject: FOS: Mathematics

description: Additional file 1. A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry. Supplementary Table 1: Participating studies with number of total cases and controls per study. Supplementary Table 2: Detailed information of the characteristics of the study population by study design and case-control status. Supplementary Table 3: Associations of epidemiological risk factors for overall and ER-specific subtype breast cancer risk in population-based and cohort studies. Supplementary Table 4: Stratified analysis results for genome-wide significant interaction results by categories of risk factors. Supplementary Figure 1: Quantile-Quantile (Q-Q) plots of genome-wide interaction of A) Adult height on overall breast cancer risk and B) Age at menarche on ER+ breast cancer risk. Supplementary Figure 2: Frailty-scale heritability explained by GxE interaction on overall and estrogen receptor positive breast cancer risk. Supplementary Figure 3: Regional association plot for the interaction analyses between SNP rs80018847 and adult height for overall breast cancer risk. Supplementary Figure 4: Regional association plot for the interaction analyses between SNP rs4770552 and age at menarche for ER+ breast cancer risk. Supplementary Figure 5: Power (x-axis) to detect gene-environment interaction odds ratio (y-axis) at different minor allele frequencies (0.01 to 0.5: legend below) for 1:1 unmatched case-control study for different sample sizes (N = 40,000 to 120,000 with 10,000 increment). Power calculation was performed by Quanto 1.2.4, assuming a log additive model with SNP marginal effect estimate as 1.10, marginal effect estimate of the environmental risk factor as 1.20, and a two-side alpha of 5 x 10-08. We also assumed a 15% prevalence of the environmental risk factor and 1% prevalence of the disease.