cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 2: of Is it a matter of urgency? A survey of assessments by walk-in patients and doctors of the urgency level of their encounters at a general emergency outpatient clinic in Oslo, Norway
Creators: name: Ruud, Sven
name: Hjortdahl, Per
name: BĂĽrd Natvig
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Concordance for urgency assessment levels between patients and doctors stratified by consultation results. Additional table showing the concordance for urgency assessment levels between patients and doctors stratified by consultation results. A: Received final treatment at the emergency clinic, B: Admitted to hospital/decision unit or referred to specialist and C: RGP follow up.
Additional file 3: of Is it a matter of urgency? A survey of assessments by walk-in patients and doctors of the urgency level of their encounters at a general emergency outpatient clinic in Oslo, Norway
Creators: name: Ruud, Sven
name: Hjortdahl, Per
name: Natvig, Bård
Publisher: name: Figshare
Year: 2016
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Science Policy

description: Logistic regression analysis for patients’ and doctors’ assessment of urgency level. Additional table presenting a logistic regression model for patients’ and doctors’ assessment of urgency level (dependent variable: ‘immediate’ versus ‘non-urgent’) using occupational status as a proxy for socioeconomic status. (PDF 181 kb)
title: Ð Ð°Ð·Ð²Ð¸ÑÐ¸Ðµ ÑÐ¸ÑÑÐµÐ¼Ñ ÑÑÑÐ°ÑÐµÐ³Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¿Ð»Ð°Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð² Ð¿ÑÐ¾Ð¼ÑÑÐ»ÐµÐ½Ð½Ð¾Ð¼ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²Ðµ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ ÑÐµÐ¾ÑÐµÑÐ¸ÐºÐ¾-Ð¸Ð³ÑÐ¾Ð²Ð¾Ð³Ð¾ Ð¿Ð¾Ð´Ñ Ð¾Ð´Ð°
title: ÑÐ¿ÐµÑÐ¸Ð°Ð»ÑÐ½Ð¾ÑÑÑ 5.2.3. Ð ÐµÐ³Ð¸Ð¾Ð½Ð°Ð»ÑÐ½Ð°Ñ Ð¸ Ð¾ÑÑÐ°ÑÐ»ÐµÐ²Ð°Ñ ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÐºÐ° (ÑÐµÐ³Ð¸Ð¾Ð½Ð°Ð»ÑÐ½Ð°Ñ ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÐºÐ°)
titleType: Subtitle
Creators: name: ÐÐ¸ÑÐµÐ»Ñ, ÐÐºÐ°ÑÐµÑÐ¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: ÐÑÐ¾Ð¼ÑÑÐ»ÐµÐ½Ð½ÑÐµ Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ñ
Ð¿ÑÐ¾Ð¼ÑÑÐ»ÐµÐ½Ð½Ð¾Ðµ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²Ð¾
ÑÐµÐ¾ÑÐµÑÐ¸ÐºÐ¾-Ð¸Ð³ÑÐ¾Ð²Ð¾Ð¹ Ð¿Ð¾Ð´Ñ Ð¾Ð´
ÑÑÑÐ°ÑÐµÐ³Ð¸ÑÐµÑÐºÐ¾Ðµ Ð¿Ð»Ð°Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ
ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÐºÐ¾-Ð¼Ð°ÑÐµÐ¼Ð°ÑÐ¸ÑÐµÑÐºÐ¾Ðµ Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ

description: ÐÐºÑÑÐ°Ð»ÑÐ½Ð¾ÑÑÑ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð·Ð°ÐºÐ»ÑÑÐ°ÐµÑÑÑ Ð² Ð½Ð°Ð»Ð¸ÑÐ¸Ðµ Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½Ð¾ÑÑÐµÐ¹ Ð¿Ð¾ ÑÐ°ÑÑÐ¸ÑÐµÐ½Ð¸Ñ ÑÑÑÐµÑÑÐ²ÑÑÑÐ¸Ñ Ð¿Ð¾Ð»Ð¾Ð¶ÐµÐ½Ð¸Ð¹ ÑÑÑÐ°ÑÐµÐ³Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¿Ð»Ð°Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð² ÑÐ²ÑÐ·Ð¸ Ñ ÑÑÑÐµÑÑÐ²ÐµÐ½Ð½ÑÐ¼ ÑÐ°Ð·Ð²Ð¸ÑÐ¸ÐµÐ¼ ÑÐ¸ÑÑÐ¾Ð²ÑÑ Ð¸ Ð¸Ð½ÑÐ¾ÑÐ¼Ð°ÑÐ¸Ð¾Ð½Ð½ÑÑ ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ð¹, Ð¿Ð¾Ð·Ð²Ð¾Ð»ÑÑÑÐ¸Ñ ÑÐ¾Ð²ÐµÑÑÐµÐ½ÑÑÐ²Ð¾Ð²Ð°ÑÑ Ð¿ÑÐ¾ÑÐµÑÑÑ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²ÐµÐ½Ð½Ð¾Ð¹ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÑÑ Ð² Ð´Ð¾Ð»Ð³Ð¾ÑÑÐ¾ÑÐ½Ð¾Ð¹ Ð¿ÐµÑÑÐ¿ÐµÐºÑÐ¸Ð²Ðµ. Ð¡Ð¾Ð²Ð¾ÐºÑÐ¿Ð½Ð¾ÑÑÑ Ð¿ÑÐ¸Ð½ÑÐ¸Ð¿Ð¸Ð°Ð»ÑÐ½Ð¾ Ð½Ð¾Ð²ÑÑ ÑÑÐ»Ð¾Ð²Ð¸Ð¹ ÑÑÐ°Ð½Ð¾Ð²Ð»ÐµÐ½Ð¸Ñ ÑÑÐ½Ð¾ÑÐ½Ð¾Ð¹ ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÐºÐ¸ Ð² ÑÐ¾ÑÑÐ¸Ð¹ÑÐºÐ¾Ð¹ Ð¿ÑÐ°ÐºÑÐ¸ÐºÐµ Ð¿Ð¾Ð·Ð²Ð¾Ð»Ð¸Ð»Ð¸ ÑÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°ÑÑ Ð¼Ð½Ð¾Ð³Ð¾ÑÑÐ¾Ð²Ð½ÐµÐ²ÑÐµ Ð¸ Ð²Ð·Ð°Ð¸Ð¼Ð¾ÑÐ²ÑÐ·Ð°Ð½Ð½ÑÐµ ÑÐµÐ¿Ð¾ÑÐºÐ¸ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ð¹ Ð¼ÐµÐ¶Ð´Ñ ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÑÐµÑÐºÐ¸Ð¼Ð¸ ÑÑÐ±ÑÐµÐºÑÐ°Ð¼Ð¸, Ð¾Ð´Ð½Ð°ÐºÐ¾ Ð´Ð¾ ÑÐ¸Ñ Ð¿Ð¾Ñ Ð¾ÑÑÑÑÑÑÐ²ÑÑÑ Ð´ÐµÐ¹ÑÑÐ²ÐµÐ½Ð½ÑÐµ Ð¿Ð¾Ð´ÑÐ¾Ð´Ñ Ðº Ð¿Ð¾ÑÑÑÐ¾ÐµÐ½Ð¸Ñ ÑÑÑÐ°ÑÐµÐ³Ð¸Ð¹ Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ð¹, Ð¿Ð¾Ð·Ð²Ð¾Ð»ÑÑÑÐ¸Ðµ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° ÑÐ°ÐºÑÐ¾ÑÐ¾Ð² Ð¸ Ð²ÐµÑÐ¾ÑÑÐ½Ð¾ÑÑÐµÐ¹ Ð¿ÑÐ¾Ð¸Ð·Ð²ÐµÑÑÐ¸ Ð¾Ð¿ÑÐ¸Ð¼Ð¸Ð·Ð°ÑÐ¸Ñ Ð¼ÐµÐ¶ÐºÐ¾ÑÐ¿Ð¾ÑÐ°ÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ. ÐÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ðµ ÑÐºÐ¾Ð½Ð¾Ð¼Ð¸ÐºÐ¾-Ð¼Ð°ÑÐµÐ¼Ð°ÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð°Ð¿Ð¿Ð°ÑÐ°ÑÐ° Ðº Ð¾ÑÐµÐ½ÐºÐµ Ð¼ÐµÐ¶ÐºÐ¾ÑÐ¿Ð¾ÑÐ°ÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ñ Ð¿Ð¾Ð·Ð²Ð¾Ð»Ð¸Ñ Ð²ÑÑÐ°Ð±Ð¾ÑÐ°ÑÑ Ð½Ð¾Ð²ÑÐµ ÑÑÑÐ°ÑÐµÐ³Ð¸Ð¸ ÑÐµÐ»ÐµÐ½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð½ÑÑ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ð¹ Ð² Ð¾ÑÑÐ°ÑÐ»ÑÑ Ð½Ð°ÑÐ¸Ð¾Ð½Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ ÑÐ¾Ð·ÑÐ¹ÑÑÐ²Ð°.
A $q$-version of the relation between the hypercube, the Krawtchouk chain and Dicke states
Creators: name: Bernard, Pierre-Antoine
name: Poliquin, Étienne
name: Vinet, Luc
Publisher: name: arXiv
Year: 2024
Subjects: subject: Mathematical Physics (math-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences
subject: 16T30, 81R50, 33D45

description: It is shown how the spin chain based on the dual $q$-Krawtchouk polynomials is connected to a weighted hypercube through the use of $q$-Dicke states. The representation theoretic underpinnings based on the quantum algebra $U_q(\mathfrak{su}(2))$ are emphasized.
description: 8 pages
Predicting multi-parametric dynamics of externally forced oscillator using reservoir computing and minimal data
Creators: name: Yadav, Manish
name: Chauhan, Swati
name: Shrimali, Manish Dev
name: Stender, Merten
Publisher: name: arXiv
Year: 2024
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: Classical Physics (physics.class-ph)
subject: FOS: Physical sciences
subject: J.2
subject: 70K40, 70K50

description: Mechanical systems exhibit complex dynamical behavior from harmonic oscillations to chaotic motion. The dynamics undergo qualitative changes due to changes to internal system parameters like stiffness and changes to external forcing. Mapping out complete bifurcation diagrams numerically or experimentally is resource-consuming, or even infeasible. This study uses a data-driven approach to investigate how bifurcations can be learned from a few system response measurements. Particularly, the concept of reservoir computing (RC) is employed. As proof of concept, a minimal training dataset under the resource constraint problem of a Duffing oscillator with harmonic external forcing is provided as training data. Our results indicate that the RC not only learns to represent the system dynamics for the external forcing seen during training, but it also provides qualitatively accurate and robust system response predictions for completely unknown multi-parameter regimes outside the training data. Particularly, while being trained solely on regular period-2 cycle dynamics, the proposed framework correctly predicts higher-order periodic and even chaotic dynamics for out-of-distribution forcing signals.
description: 11 pages, 4 main figures, 1 supplementary figure
MOESM1 of Chemical disguise of myrmecophilous cockroaches and its implications for understanding nestmate recognition mechanisms in leaf-cutting ants
Creators: name: Nehring, Volker
name: Dani, Francesca
name: Calamai, Luca
name: Turillazzi, Stefano
name: Bohn, Horst
name: Klaus-Dieter Klass
name: DâEttorre, Patrizia
Publisher: name: Figshare
Year: 2016
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 1. The cuticular substances of Acromyrmex octospinosus and Atta colombica workers and of Attaphila cockroaches collected from colonies of the two leaf-cutting ant species, with the relative abundances (mean and SD), retention times (rt), and principal component loadings (PC). Some substances were not found in one of the species (-). We also list the substance class as used for comparative statistics. â  x-Meâ   refers to methylated alkenes with undetermined branch position.
Pair Counting without Binning -- A New Approach to Correlation Functions in Clustering Statistics
Creators: name: Yue, Shiyu
name: Feng, Longlong
name: Ju, Wenjie
name: Pan, Jun
name: Huang, Zhiqi
name: Fang, Feng
name: Li, Zhuoyang
name: Cai, Yan-Chuan
name: Zhu, Weishan
Publisher: name: arXiv
Year: 2024
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: This paper presents a novel perspective on correlation functions in the clustering analysis of the large-scale structure of the universe. We first recognise that pair counting in bins of radial separation is equivalent to evaluating counts-in-cells (CIC), which can be modelled using a filtered density field with a binning-window function. This insight leads to an in situ expression for the two-point correlation function (2PCF). Essentially, the core idea underlying our method is to introduce a window function to define the binning scheme, enabling pair-counting without binning. This approach develops a concept of generalised 2PCF, which extends beyond conventional discrete pair counting by accommodating non-sharp-edged window functions. To extend this framework to N-point correlation functions (NPCF) using current optimal edge-corrected estimators, we developed a binning scheme independent of the specific parameterisation of polyhedral configurations. In particular, we demonstrate a fast algorithm for the three-point correlation function (3PCF), where triplet counting is accomplished by assigning either a spherical tophat or a Gaussian filter to each vertex of triangles. Additionally, we derive analytical expressions for the 3PCF using a multipole expansion in Legendre polynomials, accounting for filtered field (binning) corrections. Numerical tests using several suites of N-body simulation samples show that our approach aligns remarkably well with the theoretical predictions. Our method provides an exact solution for quantifying binning effects in practical measurements and offers a high-speed algorithm, enabling high-order clustering analysis in extremely large datasets from ongoing and upcoming surveys such as Euclid, LSST, and DESI.
description: 17 pages, 12 figures, revised version with a few typos fixed. Accepted for publication in MNRAS
TSPO acts as an immune resistance gene involved in the T cell mediated immune control of glioblastoma
Creators: name: Menevse, Ayse N.
name: Ammer, Laura-Marie
name: Vollmann-Zwerenz, Arabel
name: Kupczyk, Marcell
name: Lorenz, Julia
name: Weidner, Lorraine
name: Hussein, Abir
name: Sax, Julian
name: Mühlbauer, Jasmin
name: Heuschneider, Nicole
name: Rohrmus, Celine
name: Mai, Laura S.
name: Jachnik, Birgitt
name: Stamova, Slava
name: Volpin, Valentina
name: Durst, Franziska C.
name: Sorrentino, Antonio
name: Xydia, Maria
name: Milenkovic, Vladimir M.
name: Bader, Stefanie
name: Braun, Frank K.
name: Wetzel, Christian H.
name: Albert, Nathalie L.
name: Tonn, Joerg-Christian
name: Bartenstein, Peter
name: Proescholdt, Martin
name: Schmidt, Nils O.
name: Linker, Ralf A.
name: Riemenschneider, Markus J.
name: Beckhove, Philipp
name: Hau, Peter
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: TSPO, GB, Anti-tumor immunity, Immune-resistance, TRAIL-resistance
subject: 610 Medizin

description: Glioblastoma (GB) IDH-wildtype is the most malignant primary brain tumor. It is particularly resistant to current immunotherapies. Translocator protein 18 kDa (TSPO) is upregulated in GB and correlates with malignancy and poor prognosis, but also with increased immune infiltration. Here, we studied the role of TSPO in the regulation of immune resistance of human GB cells. The role of TSPO in tumor immune resistance was experimentally determined in primary brain tumor initiating cells (BTICs) and cell lines through genetic manipulation of TSPO expression and subsequent cocultures with antigen specific cytotoxic T cells and autologous tumor-infiltrating T cells. Death inducing intrinsic and extrinsic apoptotic pathways affected by TSPO were investigated. TSPO-regulated genes mediating apoptosis resistance in BTICs were identified through gene expression analysis and subsequent functional analyses. TSPO transcription in primary GB cells correlated with CD8+ T cell infiltration, cytotoxic activity of T cell infiltrate, expression of TNFR and IFNGR and with the activity of their downstream signalling pathways, as well as with the expression of TRAIL receptors. Coculture of BTICs with tumor reactive cytotoxic T cells or with T cell-derived factors induced TSPO up-regulation through T cell derived TNFα and IFNγ. Silencing of TSPO sensitized BTICs against T cell-mediated cytotoxicity. TSPO selectively protected BTICs against TRAIL-induced apoptosis by regulating apoptosis pathways. TSPO also regulated the expression of multiple genes associated with resistance against apoptosis. We conclude that TSPO expression in GB is induced through T cell-derived cytokines TNFα and IFNγ and that TSPO expression protects GB cells against cytotoxic T cell attack through TRAIL. Our data thereby provide an indication that therapeutic targeting of TSPO may be a suitable approach to sensitize GB to immune cell-mediated cytotoxicity by circumventing tumor intrinsic TRAIL resistance.
Additional file 1: of Effectiveness of eHealth interventions for the promotion of physical activity in older adults: a systematic review protocol
Creators: name: Muellmann, Saskia
name: Forberger, Sarah
name: MĂśllers, Tobias
name: Zeeb, Hajo
name: Pischke, Claudia
Publisher: name: Figshare
Year: 2016
Subjects: subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: PRISMA-P 2015 checklist: recommended items to address in a systematic review protocol. (PDF 212 kb)
Weak $G_2$-manifolds and scale separation in M-theory from type IIA backgrounds
Creators: name: Van Hemelryck, Vincent
Publisher: name: arXiv
Year: 2024
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: This work provides evidence for the existence of supersymmetric and scale-separated AdS$_4$ vacua in M-theory of the Freund-Rubin type. The internal space has weak $G_2$-holonomy, which is obtained from the lift of AdS vacua in massless type IIA on a specific SU(3)-structure with O6-planes. Such lifts require a local treatment of the O6-planes, therefore going beyond the usual smeared approximation. The setup is analysed by solving the pure spinor equations and the Bianchi identities perturbatively in a small backreaction parameter, preserving supersymmetry manifestly and therefore extending on previous work. This approach is applicable to lifts of other type IIA vacua on half-flat SU(3)-structures, including those with D6-brane sources. The resulting 7d manifold presented here exhibits singularities originating from the O6-planes loci in type IIA theory. Additionally, scale separation in M-theory arises from a decoupling between the Ricci curvature and the first eigenvalue of the Laplacian of the proposed 7d manifold, thereby challenging certain conjectures in the swampland program.
description: 22 pages + appendices; v2: Minor changes, accepted version in PRD
Haplostegus luteolus Conde 1936
Creators: name: Onody, Helena C.
name: Kawada, Ricardo
name: Brandão, Carlos Roberto F.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Pergidae
Haplostegus
Haplostegus luteolus

description: Haplostegus luteolus Conde, 1936: 120, 124.
(http://hol.osu.edu/spmInfo.html?id=MZSP%2045658)
 Lectotype: 1 ♀ (# MZSP 45658), [BRAZIL, São Paulo, Botucatu, Victoria, xi.1900, Hempel col], nº 5790.
description: Published as part of Onody, Helena C., Kawada, Ricardo & Brandão, Carlos Roberto F., 2014, Type specimens of Hymenoptera deposited in the Museu de Zoologia da Universidade de São Paulo, Brazil (excluding Aculeata), pp. 391-402 in Papéis Avulsos de Zoologia (São Paulo) (São Paulo) 54 (27) on page 393, DOI: 10.1590/0031-1049.2014.54.27, http://zenodo.org/record/12641096
Additional file 7: of RNA-Sequencing for profiling goat milk transcriptome in colostrum and mature milk
Creators: name: Crisà, Alessandra
name: Ferrè, Fabrizio
name: Chillemi, Giovanni
name: Moioli, Bianca
Publisher: name: Figshare
Year: 2016
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: Directed Acyclic Graphs (DAGs) for the Biological Process, Molecular Function and Cellular Component categories of up-regulated genes in D1 sample. Each node shows the number of genes in the category and the adjusted p-value indicating the significance of enrichment. GO categories in red are the enriched GO categories while the black ones are their non-enriched parents. GO categories in the top 10 that also have a p-value
Non-invasive monitoring of therapeutics using finger sweat analysis
Creators: name: Longman, Katherine Alice
Publisher: name: University of Surrey
Year: 2024
Subjects: finger sweat
fingerprints
Liquid Chromatography
Mass Spectrometry
Psychosis
Tuberculosis

description: Finger sweat is explored here as a convenient and non-invasive method of monitoring therapeutic drugs and metabolites. Finger sweat samples were collected from multiple populations (including patients receiving treatment with antipsychotics and anti-tuberculosis medications, and negative controls) and analysed by liquid chromatography mass spectrometry. In patients receiving treatment with antipsychotics, the test (based on the detection of parent drug in one finger sweat sample) was 100% effective in monitoring adherence at typically prescribed dosages. However, one of the key challenges facing finger sweat analysis is the inability determine or control sample volume. Therefore, using the previously effective drug method, endogenous compounds (such as creatinine) simultaneously detected in samples from tuberculosis patients were evaluated as indicators of sample quality and potential normalisation candidates. Finally, in a controlled administration study, normalisation of parent drug to creatinine was able smooth the pharmacokinetic elimination profile of a key anti-tuberculosis drug (isoniazid) in finger sweat. Finger sweat shows promise as a quick and dignified method of monitoring patient adherence to prescribed medications.
Longitudinal form factors of $A\,\leq\,10$ nuclei in a chiral effective field theory approach
Creators: name: King, G. B.
name: Chambers-Wall, G.
name: Gnech, A.
name: Pastore, S.
name: Piarulli, M.
name: Wiringa, R. B.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: In this work, we present the elastic electron scattering longitudinal form factors of $A\le 10$ nuclei computed in a variational Monte Carlo approach. We employ the Norfolk family of local chiral interactions and a consistent electromagnetic charge operator. Our calculations are compared both to data and past theoretical evaluations. This work represents, to our knowledge, the first exact many-body calculation of longitudinal form factors in the $7\,\leq\,A\,\leq\,10$ mass range. Finally, we identify $^9$Be and $^{10}$B as candidate targets for renewed experimental interest, as they exhibit the potential to provide more stringent constraints on the theoretical models.
description: 12 pages, 6 figures
Molecular anatomy of the pressure anisotropy in the interface of one and two component fluids: local thermodynamic description of the interfacial tension
Creators: name: Omori, Takeshi
name: Yamaguchi, Yasutaka
Publisher: name: arXiv
Year: 2024
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Through the decomposition of the pressure into the kinetic and the intermolecular contributions, we show that the pressure anisotropy in the fluid interface, which is the source of the interfacial tension, comes solely from the latter contribution. The pressure anisotropy due to the intermolecular force between the fluid particles in the same or the different fluid components is approximately proportional to the multiplication of the corresponding fluid density gradients, and from the molecular dynamics simulation of the liquid-vapor and liquid-liquid interfaces, we demonstrate that the density gradient theory (DGT) by van der Waals gives the leading order approximation of the free energy density in inhomogeneous systems, neglecting the Tolman length.
description: 20 pages, 8 figures
Conura brassolis
Creators: name: Onody, Helena C.
name: Kawada, Ricardo
name: Brandão, Carlos Roberto F.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Chalcididae
Conura
Conura brassolis

description: Conura brassolis (Schrottky, 1909): 210.
(http://hol.osu.edu/spmInfo.html?id=MZSP%206698)
 Syntypes: 2 ♀ and 2 J (# MZSP 06697, 06698), [PARAGUAY], Alto Paraná, Puerto Bertoni. Original name: Spilochalcis brassolis Schrottky, 1909.
description: Published as part of Onody, Helena C., Kawada, Ricardo & Brandão, Carlos Roberto F., 2014, Type specimens of Hymenoptera deposited in the Museu de Zoologia da Universidade de São Paulo, Brazil (excluding Aculeata), pp. 391-402 in Papéis Avulsos de Zoologia (São Paulo) (São Paulo) 54 (27) on page 395, DOI: 10.1590/0031-1049.2014.54.27, http://zenodo.org/record/12641096
Additional file 2: of Frequency and impact of confounding by indication and healthy vaccinee bias in observational studies assessing influenza vaccine effectiveness: a systematic review
Creators: name: Remschmidt, Cornelius
name: Wichmann, Ole
name: Harder, Thomas
Publisher: name: Figshare
Year: 2015
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Search strategy for the systematic review on frequency and impact of selection bias in observational studies on influenza vaccine effectiveness. (DOCX 21Â kb)
Variational autoencoders, optimal transport, and cooperative communication
Creators: name: Hao, Xiaoran
Publisher: name: No Publisher Supplied
Year: 2024

description: Variational Autoencoders (VAEs) are a class of generative models that have gained significant attention for their ability to learn complex data distributions in an unsupervised manner. VAEs have been successfully applied in various domains, including image generation, anomaly detection, and representation learning, due to their robust framework for encoding high-dimensional data into a lower-dimensional latent space. Despite their success, VAEs often encounter challenges related to optimization and the quality of generated samples. This dissertation explores the enhancement of VAEs through the integration of Entropy-regularized Optimal Transport (EOT) theory and its subsequent application in the domain of cooperative communication which formalizes a single problem comprised of interactions between two processes: action selection (teaching) and inference (learning). By recasting VAEs as an EOT problem, we proposed a novel framework that improves the model expressiveness, leading to more flexible learning processes and higher-quality generated samples. Our results on synthetic and real datasets support our statements. The second part of this dissertation considers the reversed process. We formalized a new theory of cooperative communication, which generalized the previous EOT-based cooperative communication models. We draw a connection to VAEs framework. This approach offers new theoretical and computational gains in the study of human-human and human-machine cooperation. We carry out a series of empirical simulations to support and elaborate on our theoretical results. Overall, the models and theory developed in this work contribute to the understanding of the connection between VAEs and EOT and the gap between advanced machine learning techniques and practical communication systems, offering a novel methodology with potential extensions to various applications in both fields.
Additional file 2: of Effectiveness of eHealth interventions for the promotion of physical activity in older adults: a systematic review protocol
Creators: name: Muellmann, Saskia
name: Forberger, Sarah
name: MĂśllers, Tobias
name: Zeeb, Hajo
name: Pischke, Claudia
Publisher: name: Figshare
Year: 2016
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology

description: MEDLINE search. (PDF 193 kb)
Digital Twin Enabled Data-Driven Approach for Traffic Efficiency and Software-Defined Vehicular Network Optimization
Creators: name: Shahriar, Mohammad Sajid
name: Subramaniam, Suresh
name: Matsuura, Motoharu
name: Hasegawa, Hiroshi
name: Lin, Shih-Chun
Publisher: name: arXiv
Year: 2024
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: In the realms of the internet of vehicles (IoV) and intelligent transportation systems (ITS), software defined vehicular networks (SDVN) and edge computing (EC) have emerged as promising technologies for enhancing road traffic efficiency. However, the increasing number of connected autonomous vehicles (CAVs) and EC-based applications presents multi-domain challenges such as inefficient traffic flow due to poor CAV coordination and flow-table overflow in SDVN from increased connectivity and limited ternary content addressable memory (TCAM) capacity. To address these, we focus on a data-driven approach using virtualization technologies like digital twin (DT) to leverage real-time data and simulations. We introduce a DT design and propose two data-driven solutions: a centralized decision support framework to improve traffic efficiency by reducing waiting times at roundabouts and an approach to minimize flow-table overflow and flow re-installation by optimizing flow-entry lifespan in SDVN. Simulation results show the decision support framework reduces average waiting times by 22% compared to human-driven vehicles, even with a CAV penetration rate of 40%. Additionally, the proposed optimization of flow-table space usage demonstrates a 50% reduction in flow-table space requirements, even with 100% penetration of connected vehicles.
description: 7 pages, 9 figures, conference paper
Additional file 1: of Frequency and impact of confounding by indication and healthy vaccinee bias in observational studies assessing influenza vaccine effectiveness: a systematic review
Creators: name: Remschmidt, Cornelius
name: Wichmann, Ole
name: Harder, Thomas
Publisher: name: Figshare
Year: 2015
Subjects: subject: Medicine
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Protocol for systematic review: Frequency and impact of selection bias in observational studies assessing influenza vaccine effectiveness: A systematic review. (DOCX 24Â kb)
MOESM1 of New biomarkers for primary mitral regurgitation
Creators: name: CĂŠline Deroyer
name: Magne, Julien
name: Moonen, Marie
name: Goff, Caroline Le
name: Dupont, Laura
name: Hulin, Alexia
name: Radermecker, Marc
name: Colige, Alain
name: Cavalier, Etienne
name: Kolh, Philippe
name: Pierard, Luc
name: Lancellotti, Patrizio
name: Marie-Paule Merville
name: Fillet, Marianne
Publisher: name: Figshare
Year: 2015
Subjects: subject: Cell Biology
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer

description: Additional file 1: Human discovery MAP175+ (Myriad RBM).
Chip-integrated extended-cavity mode-locked laser in the visible
Creators: name: Winkler, Lisa V.
name: Neijts, Govert
name: Bastiaens, Hubertus J. M.
name: Goodwin, Melissa J.
name: van Rees, Albert
name: Schrinner, Philip P. J.
name: Hoekman, Marcel
name: Dekker, Ronald
name: Nascimento, Adriano R. do
name: van der Slot, Peter J. M.
name: Nölleke, Christian
name: Boller, Klaus-J.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Mode-locked lasers are of interest for applications such as biological imaging, non-linear frequency conversion, and single-photon generation. In the infrared, chip-integrated mode-locked lasers have been demonstrated through integration of laser diodes with low-loss photonic circuits. However additional challenges, such as a higher propagation loss and smaller alignment tolerances have prevented the realization of such lasers in the visible range. Here, we demonstrate the first chip-integrated mode-locked diode laser in the visible using an integrated photonic circuit for cavity extension. Based on a gallium arsenide gain chip and a low-loss silicon nitride feedback circuit, the laser is passively mode-locked using a saturable absorber implemented by focused ion beam milling. At a center wavelength of 642 nm, the laser shows an average output power of 3.4 mW, with a spectral bandwidth of 1.5 nm at a repetition rate of 7.84 GHz.
description: 7 pages, 4 figures
title: Ð¡Ð²ÐµÑÐ¾Ð¿ÑÐ¾Ð·ÑÐ°ÑÐ½ÑÐµ Ð°Ð»ÑÐ¼Ð¸Ð½Ð¸ÐµÐ²ÑÐµ ÐºÐ¾Ð½ÑÑÑÑÐºÑÐ¸Ð¸ Ð·Ð´Ð°Ð½Ð¸Ñ Ð±Ð¸Ð·Ð½ÐµÑ-ÑÐµÐ½ÑÑÐ°
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: ÐÑÑÐ³Ð»Ð¾, ÐÐ¸ÐºÐ¾Ð»Ð°Ð¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2017
Subjects: Ð±Ð¸Ð·Ð½ÐµÑ-ÑÐµÐ½ÑÑ
Ð°Ð»ÑÐ¼Ð¸Ð½Ð¸ÐµÐ²ÑÐµ ÐºÐ¾Ð½ÑÑÑÑÐºÑÐ¸Ð¸
Ð¿ÑÐ¾ÐµÐºÑ ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÑÑÐ²Ð°

description: Ð ÑÐ¾Ð´Ðµ Ð²ÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð¸Ñ Ð·Ð°Ð´Ð°Ð½Ð¸Ñ Ð½Ð° Ð¿ÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð·Ð°Ð´ÑÐ¼Ð°Ð½Ñ Ð¸ ÑÐµÐ°Ð»Ð¸Ð·Ð¾Ð²Ð°Ð½Ñ Ð¾Ð±ÑÐµÐ¼Ð½Ð¾-Ð¿Ð»Ð°Ð½Ð¸ÑÐ¾Ð²Ð¾ÑÐ½ÑÐµ ÑÐµÑÐµÐ½Ð¸Ñ Ð·Ð´Ð°Ð½Ð¸Ñ Ð±Ð¸Ð·Ð½ÐµÑ-ÑÐµÐ½ÑÑÐ° ÐºÐ»Ð°ÑÑÐ° Ð, ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð° ÑÑÐµÐ¼Ð° Ð¿Ð»Ð°Ð½Ð¸ÑÐ¾Ð²ÐºÐ¸ Ð·ÐµÐ¼ÐµÐ»ÑÐ½Ð¾Ð³Ð¾ ÑÑÐ°ÑÑÐºÐ°, Ð¿ÑÐ¸Ð½ÑÑÑ ÑÐµÐ»ÐµÑÐ¾Ð¾Ð±ÑÐ°Ð·Ð½ÑÐµ ÐºÐ¾Ð½ÑÑÑÑÐºÑÐ¸Ð²Ð½ÑÐµ ÑÐµÑÐµÐ½Ð¸Ñ, ÑÐ¾Ð·Ð´Ð°Ð½Ð° Ð¼Ð¾Ð´ÐµÐ»Ñ Ð·Ð´Ð°Ð½Ð¸Ñ Ð² SCAD, Ð¿ÑÐ¾Ð¸Ð·Ð²ÐµÐ´ÐµÐ½ ÑÐ°ÑÑÐµÑ Ð·Ð´Ð°Ð½Ð¸Ñ Ð½Ð° Ð½Ð°Ð³ÑÑÐ·ÐºÐ¸, ÑÐ°ÑÑÑÐ¸ÑÐ°Ð½Ð° ÑÑÐµÐ¼Ð° Ð°ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ, ÑÐ¾ÑÑÐ°Ð²Ð»ÐµÐ½ Ð¿ÑÐ¾ÐµÐºÑ Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¸ ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÑÑÐ²Ð° Ñ ÐºÐ°Ð»ÐµÐ½Ð´Ð°ÑÐ½ÑÐ¼ Ð¿Ð»Ð°Ð½Ð¾Ð¼, Ð³ÑÐ°ÑÐ¸ÐºÐ¾Ð¼ Ð´Ð²Ð¸Ð¶ÐµÐ½Ð¸Ñ ÑÐ°Ð±Ð¾ÑÐ¸Ñ Ð¸ ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÐ½ÑÐ¼ Ð³ÐµÐ½ÐµÑÐ°Ð»ÑÐ½ÑÐ¼ Ð¿Ð»Ð°Ð½Ð¾Ð¼, Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ñ ÑÐµÑÐµÐ½Ð¸Ñ Ð¿Ð¾ Ð¾ÑÑÐ°Ð½Ðµ Ð¾ÐºÑÑÐ¶Ð°ÑÑÐµÐ¹ ÑÑÐµÐ´Ñ, ÑÐ¾ÑÑÐ°Ð²Ð»ÐµÐ½Ð° ÑÐ²Ð¾Ð´Ð½Ð°Ñ Ð¸ Ð»Ð¾ÐºÐ°Ð»ÑÐ½ÑÐµ ÑÐ¼ÐµÑÑ Ð½Ð° ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÑÑÐ²Ð¾. Ð ÑÐ°Ð¼ÐºÐ°Ñ Ð¿ÑÐ¾ÐµÐºÑÐ° ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ñ Ð¿ÑÐ¾ÐµÐºÑÐ½ÑÐµ ÑÐµÑÐµÐ½Ð¸Ñ Ð¸ ÑÐ°ÑÑÑÑ Ð½ÐµÑÑÑÐµÐ¹ ÑÐ¿Ð¾ÑÐ¾Ð±Ð½Ð¾ÑÑÐ¸ ÑÐ°ÑÐ°Ð´Ð½Ð¾Ð¹ ÑÐ²ÐµÑÐ¾Ð¿ÑÐ¾Ð·ÑÐ°ÑÐ½Ð¾Ð¹ ÐºÐ¾Ð½ÑÑÑÑÐºÑÐ¸Ð¸ Ð¸Ð· Ð°Ð»ÑÐ¼Ð¸Ð½Ð¸ÐµÐ²Ð¾Ð³Ð¾ Ð¿ÑÐ¾ÑÐ¸Ð»Ñ. ÐÑÑÐ¸ÑÐµÐºÑÑÑÐ½ÑÐµ ÑÐµÑÐµÐ½Ð¸Ñ Ð¿ÑÐ¾ÐµÐºÑÐ° Ð±ÑÐ»Ð¾ ÑÐµÑÐµÐ½Ð¾ Ð²ÑÐ¿Ð¾Ð»Ð½Ð¸ÑÑ Ð² ÑÐ¾Ð²ÑÐµÐ¼ÐµÐ½Ð½Ð¾Ð¼ Ð°ÑÑÐ¸ÑÐµÐºÑÑÑÐ½Ð¾Ð¼ ÑÑÐ¸Ð»Ðµ ÑÐ¾ ÑÐ²Ð¾Ð±Ð¾Ð´Ð½Ð¾Ð¹ Ð¿Ð»Ð°Ð½Ð¸ÑÐ¾Ð²ÐºÐ¾Ð¹ ÑÐ¸Ð¿Ð¾Ð²ÑÑ ÑÑÐ°Ð¶ÐµÐ¹, ÑÐ°ÑÐ°Ð´Ð½ÑÑ ÑÐµÑÐµÐ½Ð¸Ð¹ Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð¿ÑÐµÐ¸Ð¼ÑÑÐµÑÑÐ²ÐµÐ½Ð½Ð¾ ÑÐ²ÐµÑÐ¾Ð¿ÑÐ¾Ð·ÑÐ°ÑÐ½ÑÑ ÐºÐ¾Ð½ÑÑÑÑÐºÑÐ¸Ð¹ Ñ ÐºÐ°ÑÐºÐ°ÑÐ¾Ð¼ Ð¸Ð· Ð°Ð»ÑÐ¼Ð¸Ð½Ð¸Ñ. ÐÑÐ»Ð¸ Ð¿ÑÐ¸Ð½ÑÑÑ ÑÐµÑÐµÐ½Ð¸Ñ Ð¿Ð¾ Ð¿Ð¾Ð²ÑÑÐµÐ½Ð¸Ñ ÑÐ½ÐµÑÐ³Ð¾ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð·Ð´Ð°Ð½Ð¸Ñ, Ð¿ÑÑÐµÐ¼ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐ¾Ð²ÑÐµÐ¼ÐµÐ½Ð½ÑÑ ÑÐµÐ¿Ð»Ð¾Ð¸Ð·Ð¾Ð»Ð¸ÑÑÑÑÐ¸Ñ Ð¼Ð°ÑÐµÑÐ¸Ð°Ð»Ð¾Ð² Ð¸ Ð½Ð°Ð¸Ð±Ð¾Ð»ÐµÐµ ÑÐ½ÐµÑÐ³Ð¾ÑÐ±ÐµÑÐµÐ³Ð°ÑÑÐ¸Ñ ÑÐ²ÐµÑÐ¾Ð¿ÑÐ¾Ð·ÑÐ°ÑÐ½ÑÑ ÐºÐ¾Ð½ÑÑÑÑÐºÑÐ¸Ð¹. ÐÑÐ¾ÐµÐºÑ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð¸Ð¸ Ð²ÑÐµÑ ÑÑÐµÐ±Ð¾Ð²Ð°Ð½Ð¸Ð¹ Ð¿Ð¾ Ð´Ð¾ÑÑÑÐ¿Ð½Ð¾ÑÑÐ¸ Ð¼Ð°Ð»Ð¾Ð¼Ð¾Ð±Ð¸Ð»ÑÐ½ÑÑ Ð³ÑÑÐ¿Ð¿ Ð½Ð°ÑÐµÐ»ÐµÐ½Ð¸Ñ. Ð£ÑÑÐµÐ½Ñ ÑÑÐµÐ±Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¿Ð¾ Ð¾Ð±ÐµÑÐ¿ÐµÑÐµÐ½Ð¸Ñ Ð¿Ð¾Ð¶Ð°ÑÐ½Ð¾Ð¹ Ð±ÐµÐ·Ð¾Ð¿Ð°ÑÐ½Ð¾ÑÑÐ¸. ÐÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ñ Ð²ÑÐµ Ð¿Ð¾ÑÑÐ°Ð²Ð»ÐµÐ½Ð½ÑÐµ Ð·Ð°Ð´Ð°ÑÐ¸.
An appeal for strengthening genomic pathogen surveillance to improve pandemic preparedness and infection prevention: the German perspective
Creators: name: Salzberger, Bernd
name: Mellmann, Alexander
name: Bludau, Anna
name: Ciesek, Sandra
name: Corman, Victor
name: Dilthey, Alexander
name: Donker, Tjibbe
name: Eckmanns, Tim
name: Egelkamp, Richard
name: Gatermann, Sören G.
name: Grundmann, Hajo
name: Häcker, Georg
name: Kaase, Martin
name: Lange, Berit
name: Mielke, Martin
name: Pletz, Mathias W.
name: Semmler, Torsten
name: Thürmer, Andrea
name: Wieler, Lothar H.
name: Wolff, Thorsten
name: Widmer, Andreas F.
name: Scheithauer, Simone
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: Genomics · Surveillance · Pandemic · SARS-CoV-2 · Epidemiology
subject: 610 Medizin

description: The SARS-CoV-2 pandemic has highlighted the importance of viable infection surveillance and the relevant infrastructure. From a German perspective, an integral part of this infrastructure, genomic pathogen sequencing, was at best fragmentary and stretched to its limits due to the lack or inefficient use of equipment, human resources, data management and coordination. The experience in other countries has shown that the rate of sequenced positive samples and linkage of genomic and epidemiological data (person, place, time) represent important factors for a successful application of genomic pathogen surveillance. Planning, establishing and consistently supporting adequate structures for genomic pathogen surveillance will be crucial to identify and combat future pandemics as well as other challenges in infectious diseases such as multi-drug resistant bacteria and healthcare-associated infections. Therefore, the authors propose a multifaceted and coordinated process for the definition of procedural, legal and technical standards for comprehensive genomic pathogen surveillance in Germany, covering the areas of genomic sequencing, data collection and data linkage, as well as target pathogens. A comparative analysis of the structures established in Germany and in other countries is applied. This proposal aims to better tackle epi- and pandemics to come and take action from the “lessons learned” from the SARS-CoV-2 pandemic.
Quantification of bulk lipid species in human platelets and their thrombin-induced release
Creators: name: Heimerl, Susanne
name: Höring, Marcus
name: Kopczynski, Dominik
name: Sigruener, Alexander
name: Hart, Christina
name: Burkhardt, Ralph
name: Black, Anne
name: Ahrends, Robert
name: Liebisch, Gerhard
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: 610 Medizin

description: Lipids play a central role in platelet physiology. Changes in the lipidome have already been described for basal and activated platelets. However, quantitative lipidomic data of platelet activation, including the released complex lipids, are unavailable. Here we describe an easy-to-use protocol based on flow-injection mass spectrometry for the quantitative analysis of bulk lipid species in basal and activated human platelets and their lipid release after thrombin activation. We provide lipid species concentrations of 12 healthy human donors, including cholesteryl ester (CE), ceramide (Cer), free cholesterol (FC), hexosylceramide (HexCer), lysophosphatidylcholine (LPC), lysophosphatidylethanolamine (LPE), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), phosphatidylserine (PS), sphingomyelin (SM) and triglycerides (TG). The assay exhibited good technical repeatability (CVs < 5% for major lipid species in platelets). Except for CE and TG, the inter-donor variability of the majority of lipid species concentrations in platelets was < 30% CV. Balancing of concentrations revealed the generation of LPC and loss of TG. Changes in lipid species concentrations indicate phospholipase-mediated release of arachidonic acid mainly from PC, PI, and PE but not from PS. Thrombin induced lipid release was mainly composed of FC, PS, PC, LPC, CE, and TG. The similarity of the released lipidome with that of plasma implicates that lipid release may originate from the open-canalicular system (OCS). The repository of lipid species concentrations determined with this standardized platelet release assay contribute to elucidating the physiological role of platelet lipids and provide a basis for investigating the platelet lipidome in patients with hemorrhagic or thrombotic disorders.
Adenoid cystic carcinoma of the salivary glands: a pilot study of potential therapeutic targets and characterization of the immunological tumor environment and angiogenesis
Creators: name: Michaelides, Ioannis
name: Künzel, Julian
name: Ettl, Tobias
name: Beckhove, Philipp
name: Bohr, Christopher
name: Brochhausen, Christoph
name: Mamilos, Andreas
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: Adenoid cystic carcinoma · Macrophage polarization · Neovascularization · Salivary gland cancer
subject: 610 Medizin

description: Background
Adenoid cystic carcinoma (ACC) is a rare type of cancer commonly occurring in salivary glands. It is characterized by slow but infiltrative growth, nerve infiltration and overall poor prognosis, with late recurrence and distant metastasis. The treatment of ACC is still limited to surgery and/or (adjuvant) radiotherapy. Till now no promising systemic therapy option exists. However, various studies deliver promising results after treatment with anti-angiogenetic agents, such as anti-EGFR-antibody Cetuximab or Tyrosinkinase inhibitor Lenvatinib.
Methods
By using of immunohistological methods we analyzed and compared the macrophage and lymphocyte populations, vascularization, and PD-L1-status in 12 ACC of the salivary glands.
Results
All cases showed a significant elevation of macrophages with M2 polarization and a higher vascularization in ACC compared to normal salivary gland tissue. The CD4/CD8 quotient was heterogenous. ACC does not show relevant PD-L1 expression.
Conclusions
The predominant M2 polarization of macrophages in ACC could be responsible for elevated vascularization, as already been proved in other cancer types, that M2 macrophages promote angiogenesis.
Melanosmicra acutodentata Navarro-Tavares 2008
Creators: name: Onody, Helena C.
name: Kawada, Ricardo
name: Brandão, Carlos Roberto F.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Chalcididae
Melanosmicra
Melanosmicra acutodentata

description: Melanosmicra acutodentata Navarro-Tavares &
 Tavares, 2008: 553.
 Paratypes: 4 ♀ (# MZSP 51606-51609), BRASIL, PR [Paraná], Morretes, Parque Estadual do Pau Oco, 25°34’27,5”S, 48°53’33,0”W, 09.iv.2002, Varredura de Vegetação M. T. Tavares e eq. col; 3 ♀ (MZSP 51624-51626), BRASIL, R [io de] J[aneiro], Nova Iguaçu, Res [erva] Biol [ógica] Tinguá, 22°34’38”S, 43°26’09”W, 07.iii.2002, Varredura de Vegetação, S. T. P. Amarante e eq. col; 1 J (MZSP 51610), BRASIL, S[ão] P[aulo], Ribeirão Grande, Parque Est [adual de] Intervales, 24°17’34”S, 48°22’03”W, 10-13.xii.2000, Bosque, Armadilha Malaise, M. T. Tavares e eq[uipe] col; 1 ♀ (MZSP 51611), same data except 13-16.xii.2000, Trilha; 3 ♀ (MZSP 51613-51615), BRASIL, S[ão] P[aulo], Salesópolis, Est [ação] Biol [ógica de] Boracéia, 23°39’04,8”S, 45°53’41,8”W, 01.iv.2001, Varredura de Vegetação, M. T. Tavares e eq. col; 1 ♀ (MZSP 51616), same data except 23°39’07,0”S, 45°53’43,1”W, Moericke, Bosque, 03-06.iv.2001; 5 ♀ and 1 J (MZSP 51617-51622), same data except 23°39’01,8”S, 45°52’55,5”W, 04.iv.2001, Varredura de Vegetação; 1 J (MZSP 51623), BRASIL, S[ão] P[aulo], Ubatuba, Parque Est [adual] da Serra do Mar, 23°01’55”S, 44°51’01”W, 21.i.2002, Varredura de Vegetação, N.W. Perioto e eq[uipe] col; 1 J (MZSP 51612), BRASIL, Sergipe, Crasto, S [an]ta Luzia do Itanhy, 11°22’25,1”S, 37°25’04,0”W, 31.viii.2001, Varredura de Vegetação, M. T. Tavares e eq[uipe] col.
description: Published as part of Onody, Helena C., Kawada, Ricardo & Brandão, Carlos Roberto F., 2014, Type specimens of Hymenoptera deposited in the Museu de Zoologia da Universidade de São Paulo, Brazil (excluding Aculeata), pp. 391-402 in Papéis Avulsos de Zoologia (São Paulo) (São Paulo) 54 (27) on page 395, DOI: 10.1590/0031-1049.2014.54.27, http://zenodo.org/record/12641096
Self-sustaining living habitats in extraterrestrial environments
Creators: name: Wordsworth, R.
name: Cockell, C.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Standard definitions of habitability assume that life requires the presence of planetary gravity wells to stabilize liquid water and regulate surface temperature. Here the consequences of relaxing this assumption are evaluated. Temperature, pressure, volatile loss, radiation levels and nutrient availability all appear to be surmountable obstacles to the survival of photosynthetic life in space or on celestial bodies with thin atmospheres. Biologically generated barriers capable of transmitting visible radiation, blocking ultraviolet, and sustaining temperature gradients of 25-100 K and pressure differences of 10 kPa against the vacuum of space can allow habitable conditions between 1 and 5 astronomical units in the solar system. Hence ecosystems capable of generating conditions for their own survival are physically plausible, given the known capabilities of biological materials on Earth. Biogenic habitats for photosynthetic life in extraterrestrial environments would have major benefits for human life support and sustainability in space. Because the evolution of life elsewhere may have followed very different pathways from on Earth, living habitats could also exist outside traditional habitable environments around other stars, where they would have unusual but potentially detectable biosignatures.
description: Final published version, in press at Astrobiology
Prevalence of temporomandibular disorders and bruxism in seniors
Creators: name: Rauch, Angelika
name: Nitschke, Ina
name: Hahnel, Sebastian
name: Weber, Sophia
name: Zenthöfer, Andreas
name: Schierz, Oliver
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: awake bruxism, elderly, orofacial pain, seniors, sleep bruxism, temporomandibular joint disorders
subject: 610 Medizin

description: Background
Information on the prevalence of temporomandibular disorders (TMD) or possible/probable bruxism in seniors is heterogeneous and sparse.
Objectives
To elucidate the prevalence of TMD and possible/probable bruxism in German adults aged 60 years and older.
Methods
Participants of the Interdisciplinary Longitudinal Study of Adult Development and Aging (ILSE) born between 1950–1952 (C1) and 1930–1932 (C2) were examined in 2014–2016 (fourth wave). The participants were surveyed and clinically examined by one calibrated examiner. Two questions of the Patient Health Questionnaire (PHQ) were utilised to evaluate self-reported bruxism. The clinical examination included signs of probable bruxism and the RDC/TMD examination protocol.
Results
Data from 191 participants were available. No RDC/TMD diagnosis was made in 83.2%. Of the participants, 15.2% received a single diagnosis and 1.6% multiple diagnoses that included disc displacements (9.4%) and degenerative joint diseases (8.9%). A total of 24.7% reported bruxism that included self-reported awake bruxism in 11.9% and sleep bruxism in 16.2%. Wear was clinically identified in 27.2% of the participants. No sex-related differences were observed. Significant differences were detected for probable bruxism between C1 (14.1%) and C2 (54.3%).
Conclusion
In the German population aged 60 years and older, the prevalence of TMD is 16.8%. TMD is characterised by temporomandibular joint disorders, including disc displacements and degenerative joint disorders. Bruxism was observed in a quarter of the old population.
Planet Mass Function around M stars at 1-10 au: A Plethora of sub-Earth mass objects
Creators: name: Chachan, Yayaati
name: Lee, Eve J.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Small planets ($\lesssim 1$ M$_\oplus$) at intermediate orbital distances ($\sim$1 au) represent an uncharted territory in exoplanetary science. The upcoming microlensing survey by the Nancy Grace Roman Space Telescope will be sensitive to objects as light as Ganymede and unveil the small planet population at $1-10$ au. Instrumental sensitivity to such planets is low and the number of objects we will discover is strongly dependent on the underlying planet mass function. In this work, we provide a physically motivated planet mass function by combining the efficiency of planet formation by pebble accretion with the observed disk mass function. Because the disk mass function for M dwarfs ($0.4-0.6 \, M_\odot$) is bottom heavy, the initial planet mass function is also expected to be bottom-heavy, skewing towards Ganymede and Mars mass objects, more so for heavier initial planetary seeds. We follow the subsequent dynamical evolution of planetary systems over $\sim$100 Myr varying the initial eccentricity and orbital spacing. For initial planet separations of $\geq$3 local disk scale heights, we find that Ganymede and Mars mass planets do not grow significantly by mergers. However, Earth-like planets undergo vigorous merging and turn into super-Earths, potentially creating a gap in the planet mass function at $\sim 1$ M$_{\oplus}$. Our results demonstrate that the slope of the mass function and the location of the potential gap in the mass function can probe the initial architecture of multi-planet systems. We close by discussing implications on the expected difference between bound and free-floating planet mass functions.
description: accepted for publication in ApJ
Crossed Andreev reflection revealed by self-consistent Keldysh-Usadel formalism
Creators: name: Tjernshaugen, Johanne Bratland
name: Amundsen, Morten
name: Linder, Jacob
Publisher: name: arXiv
Year: 2024
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Crossed Andreev reflection (CAR) is a process that creates entanglement between spatially separated electrons and holes. Such entangled pairs have potential applications in quantum information processing, and it is therefore relevant to determine how the probability for CAR can be increased. CAR competes with another non-local process called elastic cotunneling (EC), which does not create entanglement. In conventional normal metal/superconductor/normal metal heterostructures, earlier theoretical work predicted that EC dominates over CAR. Nevertheless, we show numerically that when the Keldysh-Usadel equations are solved self-consistently in the superconductor, CAR can dominate over EC. Self-consistency is necessary both for the conversion from a quasiparticle current to a supercurrent and to describe the spatial variation of the order parameter correctly. A requirement for the CAR probability to surpass the EC probability is that the inverse proximity effect is small. Otherwise, the subvoltage density of states becomes large and EC is strengthened by quasiparticles flowing through the superconductor. Therefore, CAR becomes dominant in the non-local transport with increasing interface resistance and length of the superconducting region. Our results show that even the simplest possible experimental setup with easily accessible normal metals and superconductors can provide dominant CAR by designing the experimental parameters correctly. We also find that spin-splitting in the superconductor increases the subvoltage density of states, and thus always favors EC over CAR. Finally, we tune the chemical potential in the leads such that transport is governed by electrons of one spin type. This can increase the CAR probability at finite values of the spin-splitting compared to using a spin-degenerate voltage bias, and provides a way to control the spin of the conduction electrons electrically.
description: 10 pages, 9 figures