cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
(101958) Elizabeth Weston
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Primary Care Providers' Perspectives on Communication with Community Pharmacists
Creators: name: Ko, Christine
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Objectives: The objective of this study is to identify what information is considered useful by primary care providers (PCPs) and what communication methods are preferred when information is shared by community pharmacists. Methods: A mixed methods approach was used to collect data from PCPs interacting with North Carolina community pharmacies participating in a prior study. In that study, community pharmacists shared 873 medication therapy problems (MTPs) with PCPs by fax. PCP responses were collected to identify whether the MTP information shared was considered “useful.” A cohort of 173 PCPs found the information “useful” and were recruited for participation in semi-structured interviews. The quantitative data were analyzed using chi-square and the qualitative interviews were analyzed using MAXQDA coding software. Results: A total of 873 MTPs were communicated to PCPs and 26% (n=230) were deemed to be useful by PCPs. Of the MTPs that were identified and deemed to be useful by PCPs, 37% (n=86) were accompanied with recommendations while 63% (n=144) were not (P=0.0316). Two PCPs completed interviews. PCPs value information about insurance coverage and medication cost; they prefer sharing information via electronic methods or fax. Variation exists among PCPs in their desire to build relationships with pharmacists. PCPs do not always consider community pharmacists as members of the interdisciplinary team but do believe successful communication must occur before a working relationship can be established. Conclusion: Community pharmacists should take into consideration specific PCP preference of communication methods and usefulness of information shared when establishing a collaborative relationship with PCPs.
The overmassive black hole in NGC 1277: new constraints from molecular gas kinematics
Creators: name: Scharwächter, J.
name: Combes, F.
name: Salomé, P.
name: Sun, M.
name: Krips, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We report the detection of CO(1-0) emission from NGC 1277, a lenticular galaxy in the Perseus Cluster. NGC 1277 has previously been proposed to host an overmassive black hole (BH) compared to the galaxy bulge luminosity (mass), based on stellar-kinematic measurements. The CO(1-0) emission, observed with the IRAM Plateau de Bure Interferometer (PdBI) using both, a more compact (2.9-arcsec resolution) and a more extended (1-arcsec resolution) configuration, is likely to originate from the dust lane encompassing the galaxy nucleus at a distance of 0.9 arcsec (~320 pc). The double-horned CO(1-0) profile found at 2.9-arcsec resolution traces $1.5\times 10^8\ M_\odot$ of molecular gas, likely orbiting in the dust lane at $\sim 550\ \mathrm{km\ s^{-1}}$, which suggests a total enclosed mass of $\sim 2\times 10^{10}\ M_\odot$. At 1-arcsec resolution, the CO(1-0) emission appears spatially resolved along the dust lane in east-west direction, though at a low signal-to-noise ratio. In agreement with the previous stellar-kinematic measurements, the CO(1-0) kinematics is found to be consistent with an $\sim 1.7\times 10^{10}\ M_\odot$ BH for a stellar mass-to-light ratio of $M/L_V=6.3$, while a less massive BH of $\sim 5\times 10^{9}\ M_\odot$ is possible when assuming a larger $M/L_V=10$. While the molecular gas reservoir may be associated with a low level of star formation activity, the extended 2.6-mm continuum emission is likely to originate from a weak AGN, possibly characterized by an inverted radio-to-millimetre spectral energy distribution. Literature radio and X-ray data indicate that the BH in NGC 1277 is also overmassive with respect to the Fundamental Plane of BH activity.
description: 15 pages, 13 figures; accepted for publication in MNRAS on 20 January 2016; updated version including minor changes and note added in proof
title: Der Streit um die Birne. Autorschafts-Attributionstest mit Burrows’ Delta und dessen Optimierung für Kurztexte am Beispiel der ‚Halben Birne‘ des Konrad von Würzburg
title: Anhang – Dimpel: Gute Wörter und Level-2-Differenzen bei Delta
titleType: Subtitle
Creators: name: Dimpel, Friedrich Michael
name: Zeppezauer-Wachauer, Katharina
name: Schlager, Daniel
Publisher: name: Universitäts- und Landesbibliothek Münster
Year: 2019
Subjects: subject: 830 German literature and literatures of related languages

description: Begleitende Datenpublikation zum Aufsatz "Der Streit um die Birne. Autorschafts-Attributionstest mit Burrows’ Delta und dessen Optimierung für Kurztexte am Beispiel der ‚Halben Birne‘ des Konrad von Würzburg" von Friedrich Michael Dimpel, Katharina Zeppezauer-Wachauer und Daniel Schlager, der im Themenheft "Digitale Mediävistik" der Zeitschrift "Das Mittelalter", Band 24/1 (2019) erschien. Enthalten sind die Messdaten zum Beitrag in Form einer PDF-Präsentation.
(101954) Thomas Watkins
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Interaction of Nucleoside Reverse Transcriptase Inhibitor Pharmacology and Aging in the Multicenter AIDS Cohort Study
Creators: name: Wings, Emily
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: The HIV-infected population is aging. Therefore, considerations concerning the effect of aging on the safety and efficacy of antiretroviral (ARV) therapy are needed. Nucleoside reverse transcriptase inhibitors’ (NRTIs) level of inhibition of viral reverse transcriptase is influenced by the ratio of intracellular metabolites (IM) to endogenous deoxynucleotides (EN) within the cell. We sought to examine the effect of aging on NRTI pharmacology in HIV+ men within the Multicenter AIDS Cohort Study (MACS). Stored peripheral blood mononuclear cell (PBMC) samples were analyzed from 152 men (83 aged ≤45 years and 69 aged ≥60 years) enrolled in the MACS, receiving tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) with undetectable viral loads. Median values were based upon the Turnbull estimator, and a log-rank test was used to conduct the cross-sectional analysis of IM:EN ratios between age groups. The reported preliminary results suggest numerically increased median TFVdp and FTCtp concentrations within men aged ≥60 years. The TFVdp:dATP ratio was statistically significantly higher in men ≥60 years of age, compared to those ≤45 years of age (0.664 vs. 0.294, P=0.0002). No statistically significant difference was found in the FTCtp:dCTP ratio between age groups. The elevated TFVdp:dATP ratio observed in men aged ≥60 years is likely a result of increased inflammation within the older population. The lack of a statistically significant difference in the FTCtp:dCTP ratio between groups may be explained by confounding increased cellular senescence within older men and/or the exclusion of ratios with measured dCTP below the limit of quantification.
Femtosecond control of electric currents at the interfaces of metallic ferromagnetic heterostructures
Creators: name: Huisman, T. J.
name: Mikhaylovskiy, R. V.
name: Costa, J. D.
name: Freimuth, F.
name: Paz, E.
name: Ventura, J.
name: Freitas, P. P.
name: Blügel, S.
name: Mokrousov, Y.
name: Rasing, Th.
name: Kimel, A. V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The idea to utilize not only the charge but also the spin of electrons in the operation of electronic devices has led to the development of spintronics, causing a revolution in how information is stored and processed. A novel advancement would be to develop ultrafast spintronics using femtosecond laser pulses. Employing terahertz (10$^{12}$ Hz) emission spectroscopy, we demonstrate optical generation of spin-polarized electric currents at the interfaces of metallic ferromagnetic heterostructures at the femtosecond timescale. The direction of the photocurrent is controlled by the helicity of the circularly polarized light. These results open up new opportunities for realizing spintronics in the unprecedented terahertz regime and provide new insights in all-optical control of magnetism.
description: 3 figures and 2 tables in the main text
Time-kill Effect of Polymyxin in Combination with Meropenem against Multi-Drug Resistant Pseudomonas aeruginosa
Creators: name: Tran, Kevin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Polymyxin B based combinations may improve clinical outcomes by utilizing its rapid killing potential in conjunction with the sustained action of meropenem. The objective of the study is to evaluate the pharmacodynamic activity of polymyxin B in combination with meropenem against Pseudomonas aeruginosa clinical isolates. Antibiotics used in combination should have better pharmacodynamic killing activity against P. aeruginosa clinical isolates and should result in suppressed regrowth patterns as compared to monotherapy.
In-vitro static time-kill experiments were performed using P. aeruginosa clinical isolates with differing susceptibilities, polymyxin B resistant (PBr) strain PSA215 and polymyxin B sensitive (PBs) strain PSA218 to evaluate the killing activity of polymyxin based combinations with meropenem.
Anthocyanins reduce cell invasion and migration through Akt/mTOR downregulation, but not through apoptosis activa-tion in triple-negative breast cancer cells: a systematic review and meta-analysis
Creators: name: Noratto, Giuliana
name: Shinzato, Vivian Izumi
name: Ong, Thomas Prates
name: De Aquino Guerreiro, Caroline
name: Rabelo, Ana Carolina Silveira
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Life Sciences

description: The article entitled "Anthocyanins reduce cell invasion and migration through Akt/mTOR downregulation, but not through apoptosis activa-tion in triple-negative breast cancer cells: a systematic review and meta-analysis" aimed to analyze the primary studies available in the literature and perform a systematic review and meta-analysis. The manuscript question was: "Does anthocyanins from enriched extracts, or cyanidin-3-O-glucoside, modulate migration, invasion, cell growth pathways (Akt/mTOR), apoptosis, MAPK in breast cancer cells triple negative?" For this, a literature search was performed using the Pubmed and Scopus databases with the search words: breast cancer AND (anthocyanins OR cyanidin-3-glucoside). The articles found in the search had their titles and abstracts analyzed regarding the previously defined inclusion and exclusion criteria. Those who matched the inclusion criteria had their entire text scanned. Those that were still included had mean and standard deviation data extracted using the WebPlotDigitizer tool. These data were statistically analyzed by Review Manager's software. Then, the generated forest plot graphics were used for writing the article.
The Use of a Mechanism-Based Model (MBM) to Better Characterize the Pharmacology of Combination Colistin (COL) and Ceftazidime/Avibactam (CZA) Across Five Carbapenem-resistant Klebsiella pneumoniae Strains
Creators: name: Piscitelli, Joseph
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Introduction: Carbapenem-resistant Klebsiella pneumoniae are resistant to multiple classes of antibiotics and often necessitating the need for combination therapy to ensure adequate sustained killing activity and prevent the emergence of resistance. Previous in vitro studies have shown that the combination of colistin (COL) and ceftazidime/avibactam (CZA) resulted in sustained activity against Klebsiella pneumoniae.

Methods: Five Klebsiella pneumoniae clinical isolates were utilized. (COL MIC: 0.5-32mg/L; CZA MIC: 0.5-2mg/L). COL (0.5, 1, 2, 4, 8, 16mg/L) and CZA (16/4, 32/8, 64/16, 128/32mg/L) were evaluated alone
and in combination (COL 0.5, 1, 2, 4mg/L and CZA 16/4, 32/8, 64/16 mg/L) against an initial inoculum of~106 CFU/mL over 24 hours. Model development was conducted using a pooled approach with
maximum likelihood estimation in ADAPT-5 and S-ADAPT-TRAN.

Results: The mechanism-based model (MBM) characterized both drugs as exerting their pharmacological effect on the death rate of the bacteria. The MBM was able to capture the reduction in bacterial burden and rapid regrowth well (R2 = 0.974). The model precision was fair as characterized by parameter coefficient of variation.

Conclusions: The MBM was able to capture the static time-kill experimental data well and help to better understand the effects of each drug in monotherapy and in combination. The model was accurately able to explain the killing effects of COL and CZA. This information will enable us to optimize and translate these antibiotic regimens to better fight infections caused by such hard-to-treat pathogens and prolong the efficacy of these existing viable antibiotics.
Protocol dependence of the jamming transition
Creators: name: Bertrand, T.
name: Behringer, R. P.
name: Chakraborty, B.
name: O'Hern, C. S.
name: Shattuck, M. D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We propose a theoretical framework for predicting the protocol dependence of the jamming transition for frictionless spherical particles that interact via purely repulsive contact forces. We study isostatic jammed disk packings obtained via two protocols: isotropic compression and simple shear. We show that for frictionless systems, all jammed packings can be obtained via either protocol. However, the probability to obtain a particular jammed packing depends on the packing-generation protocol. We predict the average shear strain required to induce jamming in initially unjammed packings from the measured probability to jam at packing fraction $ϕ$ from isotropic compression. We compare our predictions to results from numerical simulations of jamming and find quantitative agreement. We also show that the packing fraction range, over which strain-induced jamming occurs, tends to zero in the large system limit for frictionless packings with overdamped dynamics.
description: 8 pages, 7 figures
The Health and Economic Impact of Substandard and Falsified Antimalarials in Myanmar
Creators: name: Han, Jinah
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Significant efforts have been made in the fight against malaria in the greater Mekong subregion, but two-thirds of the population in Myanmar still reside in high-risk regions for malaria infections. Substandard and falsified antimalarial medications pose a threat to disease transmission, efforts to control antimalarial resistance, and eliminate malaria from the region. This study is the first to estimate the health and economic impact of substandard and falsified antimalarials in Myanmar. Malaria illness, care seeking and health outcomes were simulated using the Substandard and Falsified Antimalarial Research Impact (SAFARI) model, a probabilistic agent-based model. Myanmar-specific epidemiologic, demographic and cost inputs were extracted from existing literature. The total annual cost of malaria in Myanmar was estimated to be $14.084 (95% CI: $14.040-14.128) million, including $2.719 (95% CI: $2.715-2.722) million in direct costs. Substandard and falsified antimalarials contributed $2 million to the total annual, including $16,000 in direct costs. The model estimated that poor-quality antimalarials contributed to 33% of hospitalizations in Myanmar. In the event of widespread artemisinin resistance, we simulated an additional $550,000 in yearly costs. The presence of poor-quality antimalarials are hampering efforts to reduce malarial disease burden, control the spread of antimalarial resistance, and eliminate malaria in Myanmar and the greater Mekong subregion.
(101955) Isabel Watkins
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Strong Correlations in a nutshell
Creators: name: Ferrero, M.
name: De Leo, L.
name: Lecheminant, P.
name: Fabrizio, M.
Publisher: name: arXiv
Year: 2007
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We present the phase diagram of clusters made of two, three and four coupled Anderson impurities. All three clusters share qualitatively similar phase diagrams that include Kondo screened and unscreened regimes separated by almost critical crossover regions reflecting the proximity to barely avoided critical points. This suggests the emergence of universal paradigms that apply to clusters of arbitrary size. We discuss how these crossover regions of the impurity models might affect the approach to the Mott transition within a cluster extension of dynamical mean field theory.
description: 45 pages, 14 figures. To appear in Journal of Physics: Condensed Matter
title: MRI of the scapulothoracic joint: diagnostic features of elastofibroma dorsi and scapulothoracic bursitis with an emphasis on the differential diagnosis
Creators: name: Vidoni , Alessandro
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Neoplasia
subject: Inflammation
subject: Technology assessment
subject: Imaging sequences
subject: Education
subject: MR
subject: Oncology
subject: Musculoskeletal system
subject: Musculoskeletal joint

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Review of the anatomy and the function of the scapulothoracic joint with a focus on the appropriate MRI protocol. Evaluation of the most common imaging findings of elastofibroma dorsi and scapulothoracic bursitis as an important differential...
Dynamics of a solar prominence tornado observed by SDO/AIA on 2012 November 7-8
Creators: name: Mghebrishvili, I.
name: Zaqarashvili, T. V.
name: Kukhianidze, V.
name: Ramishvili, G.
name: Shergelashvili, B.
name: Veronig, A.
name: Poedts, S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We study the detailed dynamics of a solar prominence tornado using time series of 171, 304, 193 and 211 Å spectral lines obtained by Solar Dynamics Observatory/ Atmospheric Imaging Assembly during 2012 November 7-8. The tornado first appeared at 08:00 UT, November 07, near the surface, gradually rose upwards with the mean speed of $\sim$ 1.5 km s$^{-1}$ and persisted over 30 hr. Time-distance plots show two patterns of quasi-periodic transverse displacements of the tornado axis with periods of 40 and 50 minute at different phases of the tornado evolution. The first pattern occurred during the rising phase and can be explained by the upward motion of the twisted tornado. The second pattern occurred during the later stage of evolution when the tornado already stopped rising and could be caused either by MHD kink waves in the tornado or by the rotation of two tornado threads around a common axis. The later hypothesis is supported by the fact that the tornado sometimes showed a double structure during the quasi-periodic phase. 211 and 193 Å spectral lines show a coronal cavity above the prominence/tornado, which started expansion at $\sim$ 13:00 UT and continuously rose above the solar limb. The tornado finally became unstable and erupted together with the corresponding prominence as coronal mass ejection (CME) at 15:00 UT, November 08. The final stage of the evolution of the cavity and the tornado-related prominence resembles the magnetic breakout model. On the other hand, the kink instability may destabilize the twisted tornado, and consequently prominence tornadoes can be used as precursors for CMEs.
description: 18 pages, 7 figures, Accepted in ApJ
(101956) Charlotte Watkins
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Formulation and Target Identification of D8, a Host-Directed Antibiotic
Creators: name: Zheng, Linda
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Host-directed therapeutics present a new strategy to combat antibiotic resistance. We discovered a molecule, D8, that inhibits intracellular growth of Francisella tularensis in cell culture and mouse studies. However, the limited solubility of D8 leads to variability in dosing and the mechanism of action of D8 is unknown. Consequently, the objectives of this study are to increase the solubility of D8 utilizing salt formation and beta-cyclodextrin derivatives, as well as, identification of proteins that interact with D8 through chemoproteomics experiments. 
An absorbance-based solubility assay was developed based on our observation of increased absorbance above 400 nm for D8 aggregates. When D8 is completely soluble, the absorbance at 400 nm is close to the baseline value. However, once D8 reaches saturation state, the absorbance intensity increases linearly with concentration. D8-33 and D8-34 are D8 and D8-05 (inactive analog of D8) derivatives with a diazirine group and a terminal alkyne. J774 cells were incubated with either D8-33 or D8-34. After incubation, the cells were illuminated at 365 nm to crosslink D8-33 or D8-34 with its interacting proteins. After cell lysis, the cell lysate was conjugated with biotin-N3 through click reaction and the resulting labeled proteins were subsequently enriched with streptavidin-coated resins for proteomics studies. 
Methyl-beta-cyclodextrin substantially increases the solubility of D8 from 0.03 mM to 2.9 mM, enabling the delivery of D8 within 100 ul PBS to reach dosage of 5 mg/kg for mouse studies. Captisol® and (2-hydroxypropyl)-beta-cyclodextrin increase the solubility of D8 to 0.19 mM and 0.61 mM, respectively. In contrast, salt formations do not significantly increase D8’s solubility. We also optimized the conditions for click reactions to couple D8-interacting proteins with biotin-N3. 
We developed a formulation that enhances D8’s solubility by 100 times, enabling accurate dosing for animal studies. To identify D8-interacting proteins, we modified “click” reaction protocols. Further chemoproteomic studies should be completed to provide a list of potential D8-interacting proteins to provide not only more insight into the mechanism of D8’s antibacterial activity, but also new therapeutic targets for future drug discovery.
title: Imaging acute and emergency otological cases with high resolution CT temporal bones scan.
Creators: name: Kumar, Raekha
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Ear / Nose / Throat
subject: CT
subject: Education
subject: Acute

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Awareness of the indications of high resolution CT temporal bone scans in the emergency and acute clinical setting. Understanding of normal anatomy on CT temporal bones. To recognise the radiological findings of common acute pathology of the...
Facilitating Medication Optimization Interventions through Implementation Readiness
Creators: name: O'Neil, Adam
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Primary care practices and other outpatient clinics are increasingly interested in delivering advanced pharmacy services, but there is often a general lack of readiness (i.e. motivation and capacity) to implement them. Investigators first conducted a targeted literature review to elucidate evidence-based strategies to build readiness for implementation in healthcare settings. The use of these strategies was then evaluated in 3 outpatient clinics through the use of structured interviews and ongoing feedback from the sites during their use of a structured readiness-building process. 56 individual readiness-building strategies were identified across 31 eligible publications. The outpatient sites showed mixed reactions to the use of these readiness-building strategies, with many finding it difficult to remain committed to the process on a longitudinal basis. More implementation research using these strategies is needed to identify best practices.
title: CT-Colonography (CTC) in the Diagnosis of Rectal Pathology: Evaluation of Benign and Malignant Lesions and Algorithms for Appropriate Management.
Creators: name: Martínez-Sapiña Llanas, María José
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Colonography CT
subject: CT
subject: Colon
subject: Abdomen
subject: Cancer

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Review the semiology of different rectal lesions presented at CT-Colonography (CTC). Provide helpful working algorithms for the further handling of the...
Spherical quadrilaterals with three non-integer angles
Creators: name: Eremenko, Alexandre
name: Gabrielov, Andrei
name: Tarasov, Vitaly
Publisher: name: arXiv
Year: 2015
Subjects: subject: Complex Variables (math.CV)
subject: Mathematical Physics (math-ph)
subject: Metric Geometry (math.MG)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 30C20, 34M03

description: We classify spherical quadrilaterals up to isometry in the case when one inner angle is a multiple of pi while the other three are not. This is equivalent to classification of Heun's equations with real parameters and one apparent singularity such that the monodromy consists of unitary transformations.
description: 38 pages, 16 figures. arXiv admin note: text overlap with arXiv:1409.1529
Effects of Exercise-based Interventions on Chemotherapy Induced Peripheral Neuropathy: A Systematic Review
Creators: name: Friday, Bekah
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Chemotherapy induced peripheral neuropathy (CIPN) is a crippling side effect of some types of chemotherapy. Currently, there are limited treatment options. Symptoms of CIPN can be a limiting factor in treatment length and even arise after one completes chemotherapy.  In this systematic review, state of the science on existing research concerning the effectiveness of exercise-based interventions on decreasing CIPN symptoms and falls risks during or post-chemotherapy was examined. Four electronic databases (PubMed, CINAHL, Scopus, and Google Scholar) were searched using the following inclusion criteria: participants ages 18 and older, studies written in English, adults with cancer of “all types”, interventions of physical activity, exercise, or balance, and measured CIPN symptoms. Of these, 93 studies were identified, and 11 studies were included in the final sample. The studies’ interventions were categorized into balance, endurance, and multimodal exercises. Importantly, exercise-based interventions especially multimodal exercise programs, should be recommended to cancer patients. A combination of cardiovascular, resistance, and balance exercises is a low risk and feasible method to potentially decrease CIPN symptoms and one’s fall risk. Future research is needed on interventions that target CIPN symptoms.
Instagram’s Impact on Self-Esteem of Local High Schoolers
Creators: name: Pyun, Carolyn
name: Cotton, Jennifer
Publisher: name: QUBES Educational Resources
Year: 2023

description: Social media’s effects on connecting people worldwide and its exponential growth in usage sparked studies on its effect on the mental state of users. In the local community of Saratoga, Instagram particularly seemed to have the ability to negatively affect the self- esteem of teenage users from comparison and overly fixation on follower counts. However, a result from a local survey targeted toward the local high schoolers disputes most of the aspects proposed. There was a contrast in expectations on every self-esteem or insecurity-related question, suggesting that the correlation between Instagram usage and self-esteem is weak on a local scale. The results also concluded that people did generally have a superficial view of Instagram. Contrasting with expectations, follower count was not a focus to be labeled “overly fixated.” Still, the results did support that such features did not necessarily correlate with a higher self-esteem level. A look into local high schoolers’ feedback on their experiences with Instagram ultimately revealed layers of complexity on the effects of social media on society.
(101952) John Watkins
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Pulse properties of terrestrial gamma-ray flashes detected by the Fermi Gamma-Ray Burst Monitor
Creators: name: Foley, Suzanne
name: Fitzpatrick, Gerard
name: Briggs, Michael S.
name: Connaughton, Valerie
name: Tierney, David
name: McBreen, Sheila
name: Dwyer, Joseph
name: Chaplin, Vandiver L.
name: Bhat, P. Narayana
name: Byrne, David
name: Cramer, Eric
name: Fishman, Gerald J.
name: Xiong, Shaolin
name: Greiner, Jochen
name: Kippen, R. Marc
name: Meegan, Charles A.
name: Paciesas, William S.
name: Preece, Robert D.
name: von Kienlin, Andreas
name: Wilson-Hodge, Colleen
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The Gamma-ray Burst Monitor (GBM) on board the Fermi Gamma-ray Space Telescope has triggered on over 300 terrestrial gamma-ray flashes (TGFs) since its launch in June 2008. With 14 detectors, GBM collects on average ~100 counts per triggered TGF, enabling unprecedented studies of the time profiles of TGFs. Here we present the first rigorous analysis of the temporal properties of a large sample of TGFs (278), including the distributions of the rise and fall times of the individual pulses and their durations. A variety of time profiles are observed with 19 of TGFs having multiple pulses separated in time and 31 clear cases of partially overlapping pulses. The effect of instrumental dead time and pulse pileup on the temporal properties are also presented. As the observed gamma ray pulse structure is representative of the electron flux at the source, TGF pulse parameters are critical to distinguish between relativistic feedback discharge and lightning leader models. We show that at least 67% of TGFs at satellite altitudes are significantly asymmetric. For the asymmetric pulses, the rise times are almost always shorter than the fall times. Those which are not are consistent with statistical fluctuations. The median rise time for asymmetric pulses is ~3 times shorter than for symmetric pulses while their fall times are comparable. The asymmetric shapes observed are consistent with the relativistic feedback discharge model when Compton scattering of photons between the source and Fermi is included, and instrumental effects are taken into account.
Does EOL and palliative care training increase clinicians’ self-perceived knowledge and/or confidence with EOL care and communication? Findings from a Systematic Review
Creators: name: Nusser, Hayley
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Nurses care for patients approaching the end of life (EOL) regularly and are often looked towards by the patient and family members to be a source of comfort and support. Without proper EOL care and communication training, nurses may feel uncomfortable in communicating about EOL. This systematic review analyzed the effects of EOL educational intervention in nursing students, nurses, and advance practice registered nurses (APRNs). An online search of PubMed, CINAHL, and Google Scholar was conducted with the following search terms, end-of-life care, training, education, communication, skills training, nurse, nursing students, and palliative care. Inclusion criteria consisted of articles written in English, published within the last 5 years (2015-2020), studies involving nursing students, nurses, or APRNs as participants, and studies that included some form of educational intervention that measured knowledge, attitude, or confidence in regards to palliative care or EOL care. Thirty-three articles were screened for eligibility, and 7 articles were included in the final sample. With educational interventions such as group discussions, lectures, role-play, film discussions, and online training, nurses have opportunities to improve their confidence when communicating about EOL to better provide care for patients and family members. Further research in measuring actual EOL communication change is needed to demonstrate complete evidence on the necessity for this training.
title: Tumor necrosis of large and small tumors after transarterial chemoembolization with 70-150 µm and 100-300µm drug eluting embolics in ex vivo specimens in liver transplant patients
Creators: name: Heithaus, Robert Evans
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Oncology
subject: Fluoroscopy
subject: Chemoembolisation
subject: Pathology

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Drug eluting embolic (DEE) transarterial chemoembolization (TACE) continues to be used worldwide for the treatment of intermediate stage hepatocellular carcinoma (HCC). Several studies have evaluated effectiveness and depth of penetration using...
Controller Design for Robust Output Regulation of Regular Linear Systems
Creators: name: Paunonen, Lassi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optimization and Control (math.OC)
subject: FOS: Mathematics
subject: 93C05, 93B52, 93B51

description: We present three dynamic error feedback controllers for robust output regulation of regular linear systems. These controllers are (i) a minimal order robust controller for exponentially stable systems (ii) an observer-based robust controller and (iii) a new internal model based robust controller structure. In addition, we present two controllers that are by construction robust with respect to predefined classes of perturbations. The results are illustrated with an example where we study robust output tracking of a sinusoidal reference signal for a two-dimensional heat equation with boundary control and observation.
description: 26 pages, 2 figures, to appear in IEEE Transactions on Automatic Control
title: The Application of CT Texture Analysis for Prognostication of Growth Trend of the Sub-solid Pulmonary Nodules in LDCT Screening
Creators: name: Sun, Qi
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Oncology
subject: Lung
subject: CT
subject: Screening
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To evaluate the heterogeneity of different sub-solid pulmonary nodules (PNs) detected with low-dose computed tomography (LDCT) in screening population by using intensity and entropy features obtained from whole-lesion texture analysis and predict...
Pharmacist Wellness and Mental Health Analysis
Creators: name: Glass, Ashley
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Introduction:
Current literature does not take a holistic look at pharmacist wellness. The primary objective of this
project will be to survey North Carolina pharmacists in various working environments and stages of life to assess pharmacist well-being, and evaluate associations between pharmacists’ characteristics and the three areas of health and wellness: mental health, physical health, and personal health. The secondary objective is to determine areas of interrelatedness between those three areas of wellness.
Methods:
The study state’s Board of Pharmacy disseminated a survey to all actively licensed pharmacists in the state from December 20, 2018 to February 15, 2019. The survey collected pertinent demographics
and assessed mental (stress, anxiety, depression, substance use), physical (diet, exercise, sleep habits), and personal (work-life balance, hobbies, burnout, career and relationship satisfaction) health, incorporating previously validated tools adapted to create a comprehensive survey.
Results:
Response rate was n = 9.7% based on North Carolina demographics. Overall, wellness attributes in pharmacists showed concerning levels of likely anxiety, likely depression, alcohol use, negative
impacts of sleep, burnout, and high risk of distress. Being in a specific area of pharmacy practice was
significantly associated with facets of personal and physical health, but not with those of mental health. Of the significant associations, corporate community pharmacy had the highest frequency of
burnout, scoring high risk on the Well-Being Index, and not having time for relationships or hobbies.
Working ≥60 hours per week, not having children, being 30-39 years old, single, or divorced/widowed
were baseline characteristics which had the highest associations with negative indicators of wellness,
such as likely depression, and burnout. When evaluating interrelatedness between the three areas of wellness, two attributes of mental health (likely depression and likely anxiety) stood out as having significant associations with all measured facets of physical and personal health.
Conclusions:
The overall trends of mental, personal, and physical health of pharmacists are concerning. The
findings indicate characteristics which consistently stand out as being negatively associated with each area of wellness. These results mirror previous literature in pharmacists which demonstrated protective effects from being married or having children, and the detriment of working >60 hours per week. Understanding characteristics that put one at higher risk can inform employers of meaningful points of intervention for improving well-being.
(101953) Ann Watkins
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A New Suite of Statistical Algorithms for Bayesian Model Fitting with Both Intrinsic and Extrinsic Uncertainties in Two Dimensions
Creators: name: Konz, Nicholas
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020
Subjects: subject: Astronomy
subject: Statistics
subject: FOS: Mathematics

description: Fitting a statistical model to data is one of the most important tools in any scientific or data-driven field, and rigorously fitting a two dimensional statistical model to data that has intrinsic uncertainties (error bars) in both the independent variable and the dependent variable is a daunting task, especially if the data also has extrinsic uncertainty (sample variance) that cannot be fully accounted for by the error bars. Here, I introduce a novel statistic (described as the Trotter, Reichart, Konz statistic, or TRK) developed in Trotter (2011) that is advantageous towards model-fitting in this "worst-case data" scenario, especially when compared to other methods. I implemented this statistic as a suite of fitting algorithms in C++ that comes equipped with many capabilities, including: support for any nonlinear model; probability distribution generation, correlation removal and custom priors for model parameters; asymmetric uncertainties in the data and/or model, and more. I also built an end-to-end website through which the algorithm can be used easily, but generally, with a high degree of customizability. The statistic is applicable to practically any data-driven field, and I show a few examples of its usage within the realm of astronomy. This thesis along with Trotter (2011) form the foundations for Trotter, Daniel E. Reichart, and Konz (2020), in preparation. The TRK source code and web-based calculator can be found at https://github.com/nickk124/TRK and https://skynet.unc.edu/rcr/calculator/trk, respectively.
A new way to study hadron production with nuclear DIS
Creators: name: Arratia, Miguel
Publisher: name: Zenodo
Year: 2022
Subjects: hadronization
DIS
deep-inelastic scattering
Jefferson Laboratory

description: Plenary talk given at DIS2022: XXIX International Workshop on Deep-Inelastic Scattering and Related Subjects, Santiago de Compostela, Spain.
Macrophage-Derived Exosomes for the Delivery of GDNF in Parkinson’s Disease
Creators: name: Jin, Yeon Soo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Introduction: Parkinson’s disease (PD) is a neurodegenerative disease that affects the dopaminergic neurons via neuroinflammatory response activated by the presence of alpha-synuclein Lewy bodies. Current treatment of PD include small molecule therapy for symptomatic treatment, warranting the need of novel treatment options that can delay disease progression such as neurotropic factors like glial cell-line derived neurotropic factor (GDNF). One major barrier for delivery of such therapy is the blood-brain-barrier which will be bypassed by using macrophage-derived exosomes for drug delivery. Previous studies have used acute inflammation models for PD; however, because PD involves mild inflammation in earlier disease stages, transgenic murine model will be assessed to better model PD in humans. 
Methods: Transgenic mice with mutant Parkin gene (Parkin-Q311X) were treated with transfected macrophages containing GDNF at 4 months. At 16 months, the behavioral tests were performed. The animals were then sacrificed, perfused, and fixed. Ten micron sections were cut and stained with anti-alpha synuclein and anti-GFAP antibodies to assess the Lewy body and astrocytosis status. 
Results: Imaging 4 hours post-IV administration of macrophages shows accumulation of macrophages in the PD brain in comparison to no accumulation in wild-type brain. The presence of alpha-synuclein Lewy bodies was significantly lower (p < 0.05) in PD mice that were treated with GDNF-macrophages compared to PD mice treated with sham-macrophages and PBS. Astrocytosis was also significantly lower (p < 0.05) in PD mice treated with GDNF-macrophages compared to PD mice treated with sham-macrophages and PBS.
Conclusion: Treatment with GDNF-transfected macrophages improved survival of dopaminergic neurons in transgenic murine model of PD consistent with results from acute neurotoxin-induced inflammation PD models. This treatment also lowers the presence of the alpha-synuclein Lewy bodies that increase neuroinflammation ultimately leading to neurodegeneration and reduces astrocytosis.
Vignette Element Analysis for Automated Generation of Vignettes in Pharmacy Education
Creators: name: Ma, Carolyne
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Preparing cases for instruction in medical education is labor- and time-intensive, and a project was started at the UNC Eshelman School of Pharmacy to develop a tool that auto-generates patient cases on demand. In order to inform case generation, a study was implemented to analyze and describe vignette elements as they appear in medical education. We utilized a mixed methods approach involving qualitative identification of vignette elements and patterns and quantitative analysis of vignette element frequency and ordering. This study builds upon patient vignette template discussed in National Board of Medical Examiners’ (NBME) guide for constructing written test questions and adapts the template for pharmacy education (Case et al. Constructing Written Test Questions for the Basic and Clinical Sciences Third Edition. 2003; National Board of Medical Examiners.). Additionally, this study utilizes the pharmacy topic categories (e.g. Mechanism of Action) proposed in the NBME guide, and further analyzes and describes vignette element frequency in the context of these categories.