Genetic loci associated with heart rate variability and their effects on cardiac disease risk
Creators: name: Wilhelmsen, Kirk C.
name: Staessen, Jan A.
name: Kuh, Diana
name: Willemsen, Gonneke
name: Stricker, Bruno H.
name: Van Der Most, Peter J.
name: Floras, John S.
name: Penninx, Brenda
name: Meyer Zu Schwabedissen, Henriette
name: Avery, Christy L.
name: Li, Yong
name: Von Der Heyde, Benedikt
name: Nolte, Ilja M.
name: Laurie, Cathy C.
name: Siscovick, David
name: Eskola, Markku
name: Krijthe, Bouwe P.
name: Müller-Nurasyid, Martina
name: Stewart, James D.
name: Zabaneh, Delilah
name: Kerr, Kathleen F.
name: Ormel, Johan
name: Huikari, Ville
name: Li, Yun
name: Albert, Christine
name: Kumar, Jitender
name: Baker, Dewleen G.
name: Goyette, Philippe
name: Kors, Jan A.
name: Felix, Janine F.
name: Boomsma, Dorret
name: Sotoodehnia, Nona
name: Bieringa, Rob J.
name: Auvinen, Juha
name: Milaneschi, Yuri
name: Morris, Andrew P.
name: Minassian, Arpi
name: Dierckx, Bram
name: Psaty, Bruce M.
name: Hottenga, Jouke-Jan
name: Hassan, Mohammad
name: Swenne, Cees A.
name: Mahajan, Anubha
name: Greiser, Halina K.
name: Ehret, George B.
name: Tragante, Vinicius
name: Kooperberg, Charles
name: Kiviniemi, Antti M.
name: Gogarten, Stephanie M.
name: Hernesniemi, Jussi
name: Rioux, John D.
name: Jouven, Xavier
name: Lefrandt, Joop D.
name: Salvi, Erika
name: Järvelin, Marjo-Riitta
name: Jaju, Deepali
name: Limacher, Marian C.
name: Hemerich, Daiane
name: Hutri-Kähönen, Nina
name: Nikus, Kjell
name: Van Der Laan, Sander W.
name: Boucher, Gabrielle
name: Zonderman, Alan B.
name: Soliman, Elsayed Z.
name: Christophersen, Ingrid E.
name: Bis, Joshua C.
name: Kääb, Stefan
name: Uitterlinden, André G.
name: Perz, Siegfried
name: Kuznetsova, Tatiana
name: Stolarz-Skrzypek, Katarzyna
name: Raitakari, Olli T.
name: Verweij, Niek
name: Van Roon, Arie M.
name: Stein, Phyllis K.
name: Stilp, Adrienne M.
name: Hwang, Shih-Jen
name: Vaez, Ahmad
name: Risbrough, Victoria B.
name: Oldehinkel, Albertine J.
name: O'Donnell, Chris J.
name: Ellinor, Patrick T.
name: Munoz, M. Loretto
name: Sofer, Tamar
name: Maihofer, Adam X.
name: Reiner, Alexander P.
name: Taylor, Kent D.
name: Huikuri, Heikki
name: Juonala, Markus
name: Wong, Andrew
name: Lind, Lars
name: Waldenberger, Melanie
name: Geyer, Mark A.
name: Cusi, Daniele
name: Lin, Henry J.
name: Vrijkotte, Tanja G. M.
name: De Geus, Eco J.C.
name: Smith, Nicholas L.
name: Evans, Michele K.
name: Wong, Quenna
name: Neijts, Melanie
name: Peters, Annette
name: Zafarmand, Mohammad H.
name: Strauch, Konstantin
name: Hartman, Catharina A.
name: Albarwani, Sulayma
name: Thayer, Julian F.
name: Dietrich, Andrea
name: Ingelsson, Erik
name: Nalls, Mike A.
name: Liao, Duanping
name: Bayoumi, Riad
name: Jansen, Rick
name: Lehtimäki, Terho
name: Lubitz, Steven A.
name: Rotter, Jerome I.
name: Tiemeier, Henning
name: Smit, Johannes H.
name: Tinker, Lesley E.
name: Kivimaki, Mika
name: Lyytikäinen, Leo-Pekka
name: Teumer, Alexander
name: McKnight, Barbara
name: Syvänen, Ann-Christine
name: Van Dongen, Jenny
name: Axelsson, Tomas
name: Brundel, Bianca J.J.M
name: Van Setten, Jessica
name: Kluttig, Alexander
name: Tardif, Jean-Claude
name: Sundström, Johan
name: Barcella, Matteo
name: Junttila, Juhani
name: Mononen, Nina
name: Ashar, Foram
name: Alonso, Alvaro
name: Thornton, Timothy A.
name: Navis, Gerjan
name: Lindgren, Cecilia M.
name: Nivard, Michel
name: Gademan, Maaike G. J.
name: Den Hoed, Marcel
name: Van Der Harst, Pim
name: Sinner, Moritz F.
name: Nievergelt, Caroline M.
name: Kumari, Meena
name: Zhang, Zhu-Ming
name: North, Kari E.
name: Riese, Harriëtte
name: Franco, Oscar H.
name: Britton, Annie R.
name: Hofman, Albert
name: Giedraitis, Vilmantas
name: Kähönen, Mika
name: Asselbergs, Folkert W.
name: O'Connor, Daniel T.
name: Abdellaoui, Abdel
name: Amare, Azmeraw T.
name: Snieder, Harold
name: Voss, Andreas
name: Whitsel, Eric A.
name: Friberg, Peter
name: Heckbert, Susan R.
name: De Bakker, Paul I. W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in eight loci. HRV SNPs tag non-synonymous SNPs (in NDUFA11 and KIAA1755), expression quantitative trait loci (eQTLs) (influencing GNG11, RGS6 and NEO1), or are located in genes preferentially expressed in the sinoatrial node (GNG11, RGS6 and HCN4). Genetic risk scores account for 0.9 to 2.6% of the HRV variance. Significant genetic correlation is found for HRV with heart rate (−0.74<rg<−0.55) and blood pressure (−0.35<rg<−0.20). These findings provide clinically relevant biological insight into heritable variation in vagal heart rhythm regulation, with a key role for genetic variants (GNG11, RGS6) that influence G-protein heterotrimer action in GIRK-channel induced pacemaker membrane hyperpolarization.