cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Understanding hypocholesterolemic activity of soy isoflavones: Completing the puzzle through computational simulations
Creators: name: Hermanto, Feri Eko
name: Warsito, Warsito
name: Rifa’i, Muhaimin
name: Widodo, Nashi
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: The hypocholesterolemic activity of soy isoflavones has been studied, but the exact mechanism underlying the activity remains unclear. This study reveals the proposed mechanism of the cholesterol-lowering effect of soy isoflavones by computational simulations. Daidzin, Glycitin, Genistin, Daidzein, Glycitein, Genistein, Glyceollin I, Glyceollin II, and Glyceollin III were selected to be analyzed their interaction with 3-Hydroxy-3-Methyl-Glutaryl-Coenzyme A Reductase (HMGCR) and Sterol Regulatory Element-Binding Protein 2 (SREBP2) as key factors in cholesterol biosynthesis as well as Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) as a common target for hypercholesterolemia. Protein-isoflavones interaction was analyzed using AutoDock. According to binding energy calculations, a total of five out of those nine isoflavones, including Glycitin, Genistin, Genistein, Glyceollin II, and Glyceollin III, were favored to be a HMGCR inhibitor but not with SREBP2 and PCSK9. Those isoflavones were then compared with Simvastatin as known inhibitor of HMGCR. Isoflavone with binding energy lower than Simvastatin then directed to molecular dynamics using YASARA and headed into toxicity estimations. Almost all of those isoflavones could bind with HMGCR with better stability than Simvastatin according to molecular dynamics simulations. Toxicity prediction filtered two out of the five isoflavones mentioned earlier as the proper candidate to be an HMGCR inhibitor. Those isoflavones were Genistin and Genistein. In summary, the hypocholesterolemic activity of soy isoflavones may occur by blocking the cholesterol biosynthesis pathway. Communicated by Ramaswamy H. Sarma
Additional file 1 of Ethnic differences on long term outcomes of polypoidal choroidal vasculopathy after predominantly bevacizumab monotherapy
Creators: name: Yap, Aaron
name: Wang, Nancy
name: Squirrell, David
Publisher: name: figshare
Year: 2022
Subjects: subject: Cell Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Table A1. Comparison of Clinical Outcomes in the Current Study with Previously Published Real-World Observational Studies for Polypoidal Choroidal Vasculopathy Composing Different Ethnic Compositions Treated with Anti-Vascular Endothelial Growth Factor Monotherapy or Combination Therapy with Verteporfin Photodynamic Therapy.
Mudah menulis karya ilmiah menggunakan "MENDELEY"
Creators: name: Hasan, Faradila
Publisher: name: Zenodo
Year: 2022

description: Materi ini disampaikan pada acara Pelatihan Penulisan Artikel di Jurnal Pendidikan Agama Islam Musyawarah Guru Mata Pelajaran Pendidikan Agama Islam (MGMP PAI) SMP Provinsi Sulawesi Utara Manado, 07 Juli 2022
Hydrotrope assisted green synthesis of dicoumarols and in silico and in vitro antibacterial, antioxidant and xanthine oxidase inhibition studies
Creators: name: Mansi
name: Khanna, Pankaj
name: Gupta, Deepshikha
name: Yadav, Shilpa
name: Khanna, Leena
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Aqueous hydrotrope has been employed for the first time to synthesize heteroaryl dicoumarols by condensation of 4-hydroxycoumarin and different heterocyclic aldehydes. This method is highly efficient and green, and the same aqueous hydrotropic solution can be used up to five times without any considerable loss of yield in the product. The synthesized compounds showed good antibacterial potential against Gram-positive (Staphylococcus aureus/NTCC 0997 and B. oceanisediminis) and Gram-negative (Escherichia coli/D0157:H7 and E. coli rosetta) bacterial strains using the Resazurin microtiter plate visual method. The MIC value of 312 µg/ml for compounds 3b, 3k and 3l for S. aureus while 39 µg/ml for compounds 3a, 3b and 3k for E. coli and 625 µg/ml for 3a and 3b for B. oceanisediminis was observed. The compounds were screened via computational methods like molecular docking studies and molecular dynamic simulations with PDB Id’s 2W9S and 2EX6. Antioxidant activity was assessed using DPPH and H2O2 assays. Five compounds with the best binding score in molecular docking with XO (PDB ID: 1FIQ) have been tested in an in-vitro study using an enzyme inhibition assay. Novel compound 3b gave the IC50 value of 0.28 µg/ml, comparable to the standard drug Allopurinol. Communicated by Ramaswamy H. Sarma
title: MDCT Evaluation in Blunt Abdominal Trauma and Its Implications for Patient Management.
Creators: name: FERNANDA CASEIRA CABRAL,
Publisher: name: European Congress of Radiology
Year: 2011
Subjects: subject: Emergency
subject: Abdomen
subject: CT
subject: Trauma

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal Information References
description: Learning objectives: To review the spectrum of CT findings in patients with blunt abdominal trauma and describe the role of MDCT in the management of these patients. In this poster, we present an organ-system approach to abdominal trauma and supply examples of specific...
Webinar Mendeley Reference Manager: Mendeley Reference Manager (MRM) - Mendeley Cite
Creators: name: Suyanto, Helmi
Publisher: name: Zenodo
Year: 2022
Subjects: mendeley reference manager
mendeley cite
Relawan Jurnal Iindonesia

description: Disampaikan pada Webinar Mendeley Reference Manager: Mendeley Reference Manager (MRM) - Mendeley Cite yang diselenggarakan oleh PJTI (Penggiat Jurnal Teologi Indonesia), pada hari Jumat, 8 Juli 2022, pk. 09.00 s.d. 11.00 WIB
KIAT DAN PENTINGNYA MENULIS DI JURNAL ILMIAH
Creators: name: Hasan, Faradila
Publisher: name: Zenodo
Year: 2022

description: Acara Pelatihan Penulisan Artikel di Jurnal Pendidikan Agama Islam Musyawarah Guru Mata Pelajaran Pendidikan Agama Islam Smp Propinsi Sulawesi Utara Manado, 07 Juli 2022
title: Chest radiography and Computed Tomography in the evaluation of patients with hemoptysis.
Creators: name: Stefanidis, Konstantinos
Publisher: name: European Congress of Radiology
Year: 2011
Subjects: subject: Diagnostic procedure
subject: Digital radiography
subject: CT-High Resolution
subject: CT
subject: Thorax
subject: Respiratory system

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal Information References
description: Learning objectives: 1. Definition of hemoptysis 2. Present the chest radiography and the Computed Tomography (CT) findings in patients presenting hemoptysis. 3. Present the different causes of hemoptysis. 4. Evaluate the role of chest radiography and CT 5. Present the...
In-silico and in-detail experimental interaction studies of new antitumor Zn(II) complex with CT-DNA and serum albumin
Creators: name: Tabatabai, Ashraf Sadat Dorafshan
name: Dehghanian, Effat
name: Mansouri-Torshizi, Hassan
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biophysics
Biochemistry
Space Science
Medicine
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: In this study, a novel Zn(II) complex with the formula [Zn(pyrr-ac)2] (pyrr-ac: pyrrolidineacetate) was synthesized and characterized through molar conductivity, elemental analysis, 1H Nuclear Magnetic Resonance (1H NMR), UV-Visible spectroscopy, and Fourier transform infrared (FT-IR) methods. B3LYP level of DFT method along with aug-cc-pVTZ-PP/6-311G(d,p) basis set was utilized to perform the geometry optimization and HOMO-LUMO analysis. In addition, MEP, NLO and NBO computations were also performed at the same level of theory. In vitro antitumor activity of the mentioned complex on leukemia cell line, K562, was investigated using the MTT assay which surprisingly revealed the effective antitumor activity of the studied zinc complex. Interaction of this compound with biological macromolecules viz., CT-DNA and BSA was studied via different spectroscopic methods. The results of fluorescence experiment displayed that the metal complex binds to both macromolecules through hydrogen bond (H-bond) and van der Waals (vdW) forces. UV-Vis tests indicated a decline in the absorption spectra of CT-DNA/BSA in the presence of the compound. The interaction was further corroborated for CT-DNA via gel electrophoresis, CD spectroscopy and viscosity experiments and for BSA using CD spectroscopy. Furthermore, molecular docking simulation was done to evaluate the nature of interaction between the aforementioned zinc complex and CT-DNA/BSA. These results were in agreement with experimental findings and demonstrated that the main interaction is hydrogen bonding. The above type of investigations may provide a pathway through which zinc complexes join the anticancer category. The in-silico and in-vitro results confirm that the newly made [Zn(pyrr-ac)2] complex interacts with CT-DNA than BSA. Communicated by Ramaswamy H. Sarma
Hocozian, R., & Co
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1885

description: Darin: Seidenbandmuster bei Briefen 2 und 6
description: Ort: Konstantinopel (Istanbul)
description: Digitalisierung=Digitization=Numérisation TIFF 06.11.2020
Additional file 1 of An analysis of how health systems integrated priority-setting in the pandemic planning in a sample of Latin America and the Caribbean countries
Creators: name: Vélez, Claudia-Marcela
name: Aguilera, Bernardo
name: Kapiriri, Lydia
name: Essue, Beverley M.
name: Nouvet, Elysee
name: Sandman, Lars
name: Williams, Iestyn
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1. Documents reviewed in each country.
title: Nonoperative management of renal haemorrhage: role of transcatheter artery embolization (TAE)
Creators: name: Rossi, Valentina
Publisher: name: European Congress of Radiology
Year: 2011
Subjects: subject: Interventional vascular
subject: Catheter arteriography
subject: Embolisation
subject: Haemorrhage

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: Transcatheter artery embolization (TAE) represents a minimal invasive treatment for patients with renal hemorrhage. We reviewed our experience with TAE and analyzed the outcomes of patients treated with this...
Hocozian, R., & Co
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1886

description: Darin: Seidenbandmuster bei Briefen 4, 7, 9 und 12, Beilage bei Brief 10 und weitere Seidenbandmuster-Beilage
description: Ort: Konstantinopel (Istanbul)
description: Digitalisierung=Digitization=Numérisation TIFF 06.11.2020
title: Magnetic resonance imaging in patients at the risk of placental invasion: pathologic-radiologic correlation
Creators: name: Floridi, Chiara
Publisher: name: European Congress of Radiology
Year: 2011
Subjects: subject: Obstetrics (Pregnancy / birth / postnatal period)
subject: MR
subject: Observer performance
subject: Obstetrics

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: Placenta accreta (PA) is an abnormal implantation of placenta into the uterine wall; it is divided in three degrees according to the extend of trophoblastic penetration: placenta accreta vera, placenta increta and placenta percreta [1]. Patients at...
Lead optimization study on indoline-2,3-dione derivatives as potential fatty acid amide hydrolase inhibitors
Creators: name: Jaiswal, Shivani
name: Ayyannan, Senthil Raja
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Hematology

description: Based on the known isatin-based fatty acid amide hydrolase (FAAH) inhibitor BSS-7, we designed and synthesized two small sets (6–13 and 17–20) of N-1 and C-3 substituted isatin derivatives and evaluated them for their in vitro FAAH inhibition properties. The lead simplification by modification of bulky aryl moiety at N-1 with a flexible allyl group produced a nanomolar (IC50 = 6.7 nM, Ki = 5 nM) inhibitor 11 (Z)-3-((1H-benzo[d]imidazol-2-yl)imino)-1-allylindolin-2-one which exhibited a reversible and competitive FAAH inhibition with 1500 times more potency to BSS-7 (1.49 ± 0.03 µM). The lead compound 11 also showed a high blood–brain permeability and a significant antioxidant profile with no neurotoxicity. Docking results suggested that the inhibitor molecules occupied the active site of FAAH and offered optimal binding interactions. A molecular dynamics simulation study ascertained the stability of the lead inhibitor 11-FAAH complex. In silico ADMET profiling studies unveiled that compound 11 possesses good drug-like properties and merits further evaluation. Communicated by Ramaswamy H. Sarma
Ca2+ Dependence of Volume-Regulated VRAC/LRRC8 and TMEM16A Cl– Channels
Creators: name: Centeio, Raquel
name: Ousingsawat, Jiraporn
name: Schreiber, Rainer
name: Kunzelmann, Karl
Publisher: name: Universität Regensburg
Year: 2020
Subjects: subject: ANION CHANNELS; ESSENTIAL COMPONENT; INDUCED ACTIVATION; VRAC; EXPRESSION; PHYSIOLOGY; RESPONSES; DEATH; CELLS; ANO1; VRAC; CaCC; TMEM16 proteins; anoctamin; ANO1
subject: 570 Biowissenschaften, Biologie

description: All vertebrate cells activate Cl- currents (I-Cl(,swell)) when swollen by hypotonic bath solution. The volume-regulated anion channel VRAC has now been identified as LRRC8/SWELL1. However, apart from VRAC, the Ca2+-activated Cl- channel (CaCC) TMEM16A and the phospholipid scramblase and ion channel TMEM16F were suggested to contribute to cell swelling-activated whole-cell currents. Cell swelling was shown to induce Ca2+ release from the endoplasmic reticulum and to cause subsequent Ca2+ influx. It is suggested that TMEM16A/F support intracellular Ca2+ signaling and thus Ca2+-dependent activation of VRAC. In the present study, we tried to clarify the contribution of TMEM16A to I-Cl(,swell). In HEK293 cells coexpressing LRRC8A and LRRC8C, we found that activation of I-Cl(,swell) by hypotonic bath solution (Hypo; 200 mosm/l) was Ca2+ dependent. TMEM16A augmented the activation of LRRC8A/C by enhancing swelling-induced local intracellular Ca2+ concentrations. In HT29 cells, knockdown of endogenous TMEM16A attenuated I-Cl(,swell) and changed time-independent swelling-activated currents to VRAC-typical time-dependent currents. Activation of I-Cl(,swell) by Hypo was attenuated by blocking receptors for inositol trisphosphate and ryanodine (IP3R; RyR), as well as by inhibiting Ca2+ influx. The data suggest that TMEM16A contributes directly to I-Cl(,swell) as it is activated through swelling-induced Ca2+ increase. As activation of VRAC is shown to be Ca2+-dependent, TMEM16A augments VRAC currents by facilitating Hypo-induced Ca2+ increase in submembraneous signaling compartments by means of ER tethering.
Additional file 1 of Drivers of irrational use of antibiotics among children: a mixed-method study among prescribers and dispensers in Tanzania
Creators: name: Nkinda, Lilian
name: Kilonzi, Manase
name: Felix, Fatuma F.
name: Mutagonda, Ritah
name: Myemba, David T.
name: Mwakawanga, Dorkasi L.
name: Kibwana, Upendo
name: Njiro, Belinda J.
name: Ndumwa, Harrieth P.
name: Mwakalukwa, Rogers
name: Makuka, Gerald
name: Kubigwa, Samson W.
name: Marealle, Alphonce I.
name: Mikomangwa, Wigilya P.
name: Sambayi, Godfrey
name: Kunambi, Peter P.
name: Maganda, Betty A.
name: Sirili, Nathanael
name: Mfaume, Rashid
name: Nshau, Arapha Bashir
name: Bwire, George M.
name: Scherpbier, Robert
name: Nyankesha, Elevanie
name: Ndayishimiye, Pacifique
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Dispensers responses on individual questions.
title: Post-mortem CT examinations and the discovery of occult rib fractures
Creators: name: Paterson, Annie
Publisher: name: European Congress of Radiology
Year: 2011
Subjects: subject: Paediatric
subject: Musculoskeletal bone
subject: Forensic / Necropsy studies
subject: CT
subject: Medico-legal issues
subject: Forensics
subject: Pathology
subject: Trauma

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: It is well recognised that acute rib fractures are easily missed on chest radiographs, but that those which are healing are more easily detected. Accepted UK policy for imaging in suspected non-accidental injury (NAI) includes follow-up 3-view chest...
title: Magnetic resonance imaging in pancreatitis: review of 100 patients admitted and monitored in a general hospital in Niteroi-Rio de Janeiro, Brazil.
Creators: name: Fontes, Cristina
Publisher: name: European Congress of Radiology
Year: 2011
Subjects: subject: Inflammation
subject: Outcomes analysis
subject: Observer performance
subject: Cholangiography
subject: MR
subject: Pancreas
subject: Emergency
subject: Abdomen

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal Information References
description: Learning objectives: The purpose of this exhibit is to offer an overview of the disease and a spectrum of imaging findings in patients with pancreatitis, emphasizing the role of magnetic resonance imaging according to the appropriate clinical context and their...
title: Dynamic ultrasound evaluation (HRUS) of the hip: a detailed didactic approach
Creators: name: Fabbro, Emanuele
Publisher: name: European Congress of Radiology
Year: 2011
Subjects: subject: Ultrasound
subject: Musculoskeletal joint

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal Information References
description: Learning objectives: The purpose of our educational exhibit is to: 1. illustrate the normal anatomy and normal HRUS appearance of hip compartments; 2. describe a systematic technique for HRUS evaluation of such structures; 3. produce anatomical schemes with didactic...
Additional file 2 of Drivers of irrational use of antibiotics among children: a mixed-method study among prescribers and dispensers in Tanzania
Creators: name: Nkinda, Lilian
name: Kilonzi, Manase
name: Felix, Fatuma F.
name: Mutagonda, Ritah
name: Myemba, David T.
name: Mwakawanga, Dorkasi L.
name: Kibwana, Upendo
name: Njiro, Belinda J.
name: Ndumwa, Harrieth P.
name: Mwakalukwa, Rogers
name: Makuka, Gerald
name: Kubigwa, Samson W.
name: Marealle, Alphonce I.
name: Mikomangwa, Wigilya P.
name: Sambayi, Godfrey
name: Kunambi, Peter P.
name: Maganda, Betty A.
name: Sirili, Nathanael
name: Mfaume, Rashid
name: Nshau, Arapha Bashir
name: Bwire, George M.
name: Scherpbier, Robert
name: Nyankesha, Elevanie
name: Ndayishimiye, Pacifique
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2. Prescribers responses on individual questions.
Denn wir wissen nicht, was sie tun : eine Analyse der Tätigkeiten freiwillig Engagierter in Deutschland auf Basis des Freiwilligensurveys 2014
Creators: name: Kleiner, Tuuli-Marja
name: Kleiner, Tuuli-Marja
Publisher: name: Unknown
Year: 2022
Subjects: subject: Community/Rural/Urban Development
subject: Public Economics
subject: Research Methods/ Statistical Methods
subject: Freiwilliges Engagement
subject: Tätigkeitsfelder
subject: Freiwilligensurvey
subject: soziale Ungleichheit
subject: Deutschland
subject: Volunteering
subject: fields of activity
subject: German Survey on Volunteering
subject: social inequality

description: In Germany, volunteering takes place in a broad range of fields and activities. But little is known about the activity profile of the volunteers and their quantitative distribution. This paper thus focuses on capturing and quantifying the breadth and depth of profiles of volunteer activity. For this purpose, we employ representative survey data from the German Survey on Volunteering (Deutscher Freiwilligensurvey, FWS 2014). The focus is on the analysis of 12,333 answers gathered from three open questions, containing detailed task descriptions of volunteers. Using content analysis, we examined, categorized and coded information, thereby enabling detailed statistical analyses of the fields of activities. Results of the analyses show that in addition to usual activities (e.g., caregivers; accident rescuer/firefighters; sports trainers; parents councils; refugee aids; lay judges), a hodgepodge of atypical activities exist. These can include, for example, groundskeeper in the allotment garden club, route guide in the motorcycle club, organizer of social evenings and helpers at festivals of all kinds. It also becomes clear that a large proportion of volunteers carry out non-sectoral activities (secondary ancillary activities, administrative tasks or management functions). In many areas of volunteering, these activities account for more than 50 percent of total activity. The analyses also demonstrate that volunteering in Germany is socially unevenly distributed. More highly edu- cated people not only volunteer more frequently, but also increasingly engage in activities through which sym- bolic capital (status, prestige) or social influence can be gained. Further, the study reveals significant differences between the sexes: on the one hand with regard to stereotypical role models (women are more likely to care for older people or engage as parents council, while men engage as coaches in sports or as firemen); on the other hand, women are significantly underrepresented in positions that result in increased status or influence. Overall, it becomes obvious that the questionnaire of the FWS (2014) covers a wide range of activities, but results in an overestimation of commitment in the narrower sense to the concept of civic engagement (cf. German Bun- destag 2002). It is therefore recommended to revise the approach to assessing volunteerism in future studies and to link it more closely to the actual fulfilment of certain criteria.
description: DOI:10.3220/WP165597126800
Additional file 1 of Homelessness and the use of Emergency Department as a source of healthcare: a systematic review
Creators: name: Vohra, Neha
name: Paudyal, Vibhu
name: Price, Malcolm J.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. PRISMA Checklist (contains completed checklist).
A Systematic Review on Safety and Efficacy of Migalastat for the treatment of Fabry’s Disease
Creators: name: Majid, Haya
name: Verma, Neharika
name: Bhandari, Shivani
name: Gupta, Sparsh
name: Nidhi
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Medicine
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Science Policy

description: Fabry’s disease (FD) is a genetic lysosomal storage disorder characterized by α-galactosidase A (α-Gal A) lost/reduced activity. We aim to systematically assess the safety and efficacy of Migalastat, an oral pharmacological chaperone, that has been approved for the treatment of FD in patients with amenable mutations. We conducted literature search following the PRISMA guidelines in major databases up to 4 February 2024, for studies that assessed the clinical outcomes of migalastat in patients with FD. The New Castle Ottawa Scale was used to evaluate the quality of the included studies. A total of 2141 records were identified through database searches and register searches, amongst which 26 records were screened, and 12 of these were excluded. The remaining 14 reports were sought for retrieval. The 12 retrieved articles were assessed for eligibility and their quality was assessed after their inclusion. Amongst the included studies, 5 were of high quality, 6 were of medium quality, and 1 was of low quality. Migalastat showed varied effects on enzyme activity and substrate levels, with gender-specific differences noted in GL-3 substrate activity and eGFR. Overall, it improved cardiac and renal outcomes similarly to enzyme replacement therapy, with a comparable safety profile.
Additional file 2 of Homelessness and the use of Emergency Department as a source of healthcare: a systematic review
Creators: name: Vohra, Neha
name: Paudyal, Vibhu
name: Price, Malcolm J.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2. Example Search strategy.
Apechthis zapoteca
Creators: name: Khalaim, Andrey I.
name: Kasparyan, Dmitri R.
name: López-Ortega, Maurilio
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Ichneumonidae
Apechthis
Apechthis zapoteca

description: 54. Apechthis zapoteca (Cresson, 1874)
References. Gauld 1991: 479.
Material examined. Veracruz: Xalapa, N 19°30′, W 96°55′, 1279 m, Malaise trap, 2015, coll. M. López-Ortega (all in UNAM: 14–25.VII (2 ♀), 25.VII–7.VIII (2 ♀, 1 ♂), 7–20.VIII (5 ♀), 20.VIII–17.IX (3 ♀), 17.IX–2.X (1 ♂), 2–20.X (1 ♀).
Distribution. Mexico (Tamaulipas, Veracruz), Guatemala, El Salvador, Costa Rica, Brazil.
description: Published as part of Khalaim, Andrey I., Kasparyan, Dmitri R. & López-Ortega, Maurilio, 2018, New records and descriptions of Ichneumonidae (Hymenoptera) from Mexico, pp. 1-30 in Zootaxa 4486 (1) on page 20, DOI: 10.11646/zootaxa.4486.1.1, http://zenodo.org/record/1437993
title: Tomodensitometric detection in pneumoconiosis due to amorphous silica: correlation between conditions of exposure and radiological patterns.
Creators: name: Curcuruto, Roberto
Publisher: name: European Congress of Radiology
Year: 2011
Subjects: subject: CT
subject: Thorax
subject: Mediastinum
subject: Lung

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: "Liparitosis" is a pneumoconiosis due to inhalation of pumice powder, an amorphous silica material, derived from mining processes implemented on the island of Lipari (Aeolian Islands, Sicily). This pathological entity, described for the first time...
title: Role of ultrasonography in diagnosis of scrotal disorders
Creators: name: Cozcolluela Cabrejas, Rosa
Publisher: name: European Congress of Radiology
Year: 2011
Subjects: subject: Neoplasia
subject: Infection
subject: Haemorrhage
subject: Education
subject: Diagnostic procedure
subject: Ultrasound-Colour Doppler
subject: Ultrasound
subject: Genital / Reproductive system male
subject: Abdomen

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal Information References
description: Learning objectives: Ultrasonography (US) is the primary modality for imaging scrotal lesions. It provides excellent spatial resolution and has been shown to be nearly 100% sensitive in the identification of scrotal masses. In this review, we try to determine the...
title: Diffusion tensor tract-specific analysis of the anterior cingulate gyrus in subjects with suspected pre-psychotic state
Creators: name: SUZUKI, KENICHI
Publisher: name: European Congress of Radiology
Year: 2011
Subjects: subject: MR-Diffusion/Perfusion
subject: Neuroradiology brain

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: Anterior cingulate gyruis (ACG) is fibrous bundle and plays an important role in rational cognitive functions. In this study, we quantitatively evaluated changes in fractional anisotropy (FA) of the ACG by tract specific analysis to evaluate the...
A systematic review on safety and efficacy of Migalastat for the treatment of Fabry’s disease
Creators: name: Majid, Haya
name: Verma, Neharika
name: Bhandari, Shivani
name: Gupta, Sparsh
name: Nidhi, Agarwal
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Medicine
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: Fabry’s disease (FD) is a genetic lysosomal storage disorder characterized by α-galactosidase A (α-Gal A) lost/reduced activity. We aim to systematically assess the safety and efficacy of Migalastat, an oral pharmacological chaperone, that has been approved for the treatment of FD in patients with amenable mutations. We conducted literature search following the PRISMA guidelines in major databases up to 4 February 2024, for studies that assessed the clinical outcomes of migalastat in patients with FD. The New Castle Ottawa Scale was used to evaluate the quality of the included studies. A total of 2141 records were identified through database searches and register searches, amongst which 30 records were screened, and 12 of these were excluded. The remaining 20 reports were sought for retrieval. The 12 retrieved articles were assessed for eligibility and their quality was assessed. Amongst the included studies, 5 were of high quality, 6 were of medium quality, and 1 was of low quality. Migalastat showed varied effects on enzyme activity and substrate levels, with gender-specific differences noted in GL-3 substrate activity and eGFR. Overall, it improved cardiac and renal outcomes similarly to enzyme replacement therapy, with a comparable safety profile.
TMEM16A drives renal cyst growth by augmenting Ca2+ signaling in M1 cells
Creators: name: Kunzelmann, Karl
name: Cabrita, Ines
name: Buchholz, Björn
name: Schreiber, Rainer
Publisher: name: Universität Regensburg
Year: 2020
Subjects: subject: CHLORIDE SECRETION; PRIMARY CILIA; CALCIUM; POLYCYSTIN-2; ANOCTAMINS; REQUIRES; MECHANOSENSATION; ACTIVATION; ADPKD; Renal cysts; TMEM16A; Anoctamin 1; Ca2+-activated Cl- channel
subject: 570 Biowissenschaften, Biologie
subject: 610 Medizin

description: Polycystic kidney disease (PKD) leads to continuous decline of renal function by growth of renal cysts. Enhanced proliferation and transepithelial chloride secretion through cystic fibrosis transmembrane conductance regulator (CFTR) and Ca2+-activated TMEM16A Cl- channels is thought to cause an increase in cyst volume. Recent work shows the pro-proliferative role of the Ca2+ activated Cl- channel TMEM16A (anoctamin 1), and demonstrates the essential contribution of TMEM16A to CFTR-dependent Cl- secretion. The present data demonstrate an increase in intracellular Ca2+ ([Ca2+]i) signals and Cl- secretion by TMEM16A, in renal collecting duct principle cells from dog (MDCK) and mouse (M1) as well as primary tubular epithelial cells from PKD1-/- knockout mice. M1 organoids proliferated, increased expression of TMEM16A, and secreted Cl- upon knockdown of endogenous polycystin 1 or 2 (PKD1,2), by retroviral transfection with shPKD1 and shPKD2, respectively. Knockdown of PKD1 or PKD2 increased basal intracellular Ca2+ levels and enhanced purinergic Ca2+ release from endoplasmic reticulum. In contrast, ryanodine receptors were found not to be expressed in mouse renal epithelial cells and caffeine had no effects on [Ca2+]i. Ca2+ signals, proliferation, and Cl- secretion were largely reduced by knockdown or blockade of TMEM16A. TMEM16A may be therefore important for enhanced Ca2+ release from IP3-sensitive Ca2+ stores in polycystic kidney disease. Key messages center dot ADPKD leads to continuous decline of renal function by growth of renal cysts. center dot Knockdown of PKD1 or PKD2 increases TMEM16A expression. center dot TMEM16A enhanced intracellular Ca2+ signals, Cl- secretion, and proliferation. center dot TMEM16A contributes to cyst growth in ADPKD.
title: The role of gadoxetic acid (Gd-EOB-DTPA) MR imaging in the diagnosis of hepatocellular carcinoma
Creators: name: Federici, Giulia Francesca
Publisher: name: European Congress of Radiology
Year: 2011
Subjects: subject: Abdomen
subject: Contrast agents
subject: Oncology
subject: MR
subject: Neoplasia

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: INTRODUCTION The accurate and early identification of hepatocellular carcinoma (HCC) is critical for planning the most appropriate therapeutic approach. The presence on a 4-phase multidetector CT scan or dynamic contrast enhanced MRI of a nodule...
Eruga lineata Townes 1960
Creators: name: Khalaim, Andrey I.
name: Kasparyan, Dmitri R.
name: López-Ortega, Maurilio
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Ichneumonidae
Eruga
Eruga lineata

description: 55. Eruga lineata Townes, 1960
References. Hernández-Aguilar et al. 2005: 470.
Material examined. Veracruz: Xalapa, N 19°30′, W 96°55′, 1279 m, Malaise trap, 2015, coll. M. López-Ortega: 1 ♀ (UAT) 10–21.III, 2 ♀ (UNAM) 21.III–8.IV, 1 ♀ (UNAM) 2–20.X, 2 ♀ (UAT, UNAM) 20.X–2.XI. Distribution. Canada, USA, Mexico (Tamaulipas, * Veracruz).
description: Published as part of Khalaim, Andrey I., Kasparyan, Dmitri R. & López-Ortega, Maurilio, 2018, New records and descriptions of Ichneumonidae (Hymenoptera) from Mexico, pp. 1-30 in Zootaxa 4486 (1) on page 20, DOI: 10.11646/zootaxa.4486.1.1, http://zenodo.org/record/1437993
Crystallites (AFM) - MDS: B&MG
Creators: name: Bruckman, Laura
name: Yinghui Wu
name: Tripathi, Pawan
name: Maliesha Sumudumalie Kalutotage
name: French, Roger H.
name: Ciardi, Thomas
name: Mingjian Lu
Publisher: name: OSF
Year: 2024

description: This benchmark dataset and model garden focus on segmenting crystallites within two types of crystals, Spherulite and Lamellar, using Atomic Force Microscopy (AFM) images.
title: Hand dose assessment in combined cone-beam CT and real-time fluoroscopy guided needle puncture procedures using needle guidance devices
Creators: name: Schultze Kool, Leo
Publisher: name: European Congress of Radiology
Year: 2011
Subjects: subject: Interventional non-vascular
subject: Oncology
subject: Fluoroscopy
subject: CT
subject: Puncture
subject: Ablation procedures
subject: Dosimetry
subject: Metastases

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: Recently a new technology has emerged by coupling a flat panel detector with cone-beam CT (CBCT) options within an angiography interventional C-arm. [i] , [ii] The coupling between CBCT and fluoroscopy realizes a dedicated needle trajectory planning...
Neotheronia concolor Krieger 1905
Creators: name: Khalaim, Andrey I.
name: Kasparyan, Dmitri R.
name: López-Ortega, Maurilio
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Ichneumonidae
Neotheronia
Neotheronia concolor

description: 56. Neotheronia concolor Krieger, 1905
References. Gauld 1991: 434.
Material examined. Veracruz: Xalapa, N 19°30′, W 96°55′, 1279 m, Malaise trap, 2015, coll. M. López-Ortega (all in UNAM): May (1 ♀), 7–20.VIII (2 ♀, 2 ♂), 2–20.X (1 ♀, 1 ♂), 20.X–2.XI (3 ♂).
Distribution. Mexico (Guerrero, Tabasco, Tamaulipas, Veracruz), Guatemala, El Salvador, Costa Rica, Panama, Colombia, Ecuador, Brazil.
description: Published as part of Khalaim, Andrey I., Kasparyan, Dmitri R. & López-Ortega, Maurilio, 2018, New records and descriptions of Ichneumonidae (Hymenoptera) from Mexico, pp. 1-30 in Zootaxa 4486 (1) on page 20, DOI: 10.11646/zootaxa.4486.1.1, http://zenodo.org/record/1437993
Fractography (SEM) - MDS: B&MG
Creators: name: Maliesha Sumudumalie Kalutotage
name: Lewandowski, John
name: Ciardi, Thomas
name: Hernandez, Kristen
name: French, Roger H.
name: Tripathi, Pawan
name: Bruckman, Laura
Publisher: name: OSF
Year: 2024

description: This benchmark dataset and model garden focus on segmenting Scanning Electron Microscope (SEM) images of Ti64 test bars which were subjected to four point bend testing until failure
title: Transarterial chemoembolization in patients with elevated serum bilirubin
Creators: name: Kowalik, Karen
Publisher: name: European Congress of Radiology
Year: 2011
Subjects: subject: Interventional vascular
subject: Oncology
subject: Fluoroscopy
subject: Chemoembolisation
subject: Outcomes analysis
subject: Transplantation
subject: Liver

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: A serum total biliubin >2.0 mg/dL is considered a relative risk factor for a poor outcome following transarterial chemoembolization (TACE) in patients with unresectable hepatocellular carcinoma (HCC). 365 TACE cases for HCC at a single...
Al-Mg-Si Stress corrosion (XCT) - MDS: B&MG
Creators: name: Lewandowski, John
name: Tripathi, Pawan
name: Maliesha Sumudumalie Kalutotage
name: French, Roger H.
name: Ciardi, Thomas
Publisher: name: OSF
Year: 2024

description: This benchmark dataset and model garden focus on segmenting features (fractures and inclusions) from in-situ X-Ray Computed Tomography (XCT) imaging conducted on an AlMg sample.
title: The protective effect by radiological protection cream.
Creators: name: Ohtani, Hi-Rocky
Publisher: name: European Congress of Radiology
Year: 2011
Subjects: subject: Radioprotection / Radiation dose
subject: Fluoroscopy
subject: Dosimetry

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: In interventional radiology (IVR), there is exposure by X-rays being directly irradiated by the fingers of a doctor or a nurse, and exposure by scattered radiation or a secondary charged particle is also considered. Although there is the method...
Contact Corrosion (SEM) - MDS: B&MG
Creators: name: Maliesha Sumudumalie Kalutotage
name: Li, Mengjie
name: Liggett, Max A
name: Tripathi, Pawan
name: Davis, Kristopher O.
name: French, Roger H.
name: Ballen, Andrew
Publisher: name: OSF
Year: 2024
Subjects: SEM
contact-corrosion
defects
glass
interfacial-voids
material-science
metallization
silicon
silver
solar-cells
voids

description: This benchmark dataset and model garden focus on segmenting images of front contact metallization of silicon solar cells into 5 different classes (Silicon, Silver, Voids, Interfacial Voids, Glass).
Friedelin, a novel inhibitor of CYP17A1 in prostate cancer from Cassia tora
Creators: name: Joshi, Bhrugesh Pravinchandra
name: Bhandare, Vishwambhar Vishnu
name: Vankawala, Mahima
name: Patel, Prittesh
name: Patel, Rajesh
name: Vyas, Bhavin
name: Krishnamurty, Ramar
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biochemistry
Cell Biology
Pharmacology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Cancer

description: In prostate cancer (PC), drugs targeting CYP17A1 have shown great success in regulating PC progression. However, successful drug molecules show adverse side effects and therapeutic resistance in PC. Therefore, we proposed to discover the potent phytochemical-based inhibitor against CYP17A1 using virtual screening. In this study, a phytochemicals library of ∼13800 molecules was selected to screen the best possible inhibitors against CYP17A1. A molecular modelling approach investigated detailed intermolecular interactions, their structural stability, and binding affinity. Further, in vitro and in vivo studies were performed to confirm the anticancer activity of identified potential inhibitor against CYP17A1. Friedelin from Cassia tora (CT) is identified as the best possible inhibitor from the screened library. MD simulation study reveals stable binding of Friedelin to conserved binding pocket of CYP17A1 with higher binding affinity than studied control, that is, Orteronel. Friedelin was tested on hormone-sensitive (22Rv1) and insensitive (DU145) cell lines and the IC50 value was found to be 72.025 and 81.766 µg/ml, respectively. CT extract showed a 25.28% IC50 value against 22Rv1, ∼92.6% increase in late Apoptosis/Necrosis, and three folds decrease in early apoptosis in treated cells compared to untreated cells. Further, animal studies show a marked decrease in prostate weight by 39.6% and prostate index by 36.5%, along with a reduction in serum PSA level by 71.7% and testosterone level by 92.4% compared to the testosterone group, which was further validated with histopathological studies. Thus, we propose Friedelin and CT extract as potential leads, which could be taken further for drug development in PC. Communicated by Ramaswamy H. Sarma
Additional file 1 of Human fibroblasts facilitate the generation of iPSCs-derived mammary-like organoids
Creators: name: Dai, Xueqin
name: Wang, Xinye
name: Yang, Chuanyu
name: Huang, Maobo
name: Zhou, Zhongmei
name: Qu, Ying
name: Cui, Xiaojiang
name: Liu, Rong
name: Chen, Ceshi
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Developmental Biology
subject: Cancer

description: Additional file 1. Figure S1. Differentiation of human iPSCs into mEBs. (Related to Figure 1) (A). The morphology (left panel) and expression of pluripotency markers (right panel) of human iPSCs. Bar, 50 μm. (B). The morphology of mEBs after 3, 5, 7 and 10 days of suspension culture (d: days). (C). The expression profiles of different markers in mEBs after 5, 7, 10 and 14 days’ culture. Figure S2. HFF facilitates MLOs branching. (Related to Figures 1 and 4) (A). Representative bright-field images of MLOs-HFF (left panel). HFF expressing green fluorescent protein (GFP) was shown in MLOs (middle panel). HFF expression fibroblast marker α-SMA (α-Smooth Muscle Actin) and vimentin were detected (right panel). Bar, 50 μm. (B). Representative bright-field images of MLO generated from human iPSCs (left), human iPSCs with HFF (center) and human iPSCs with HFF conditioned medium (right). Bar, 50 μm. Figure S3. Co-culture of MLOs with mesenchymal cells. (A). Co-culture of mEBs with different mesenchymal cells. Bar, 500nm. (B). The organoids displayed increased branching structures after adding HFF alone or all of three mesenchymal cell lines. Bar, 100 μm. Figure S4. HFF promotes MLOs differentiation. The differential expression profiles of mammary epithelial markers between MLOs and MLOs-HFF after 30 days’ culture (d: days). The expression of CK 14 and EPCAM were increased in MLOs-HFF. Table S1. Antibody list related to Figure 1, S1, 4and S4. Table S2. The list of primer in RT-qPCR. Table S3. The information ofmRNA sequencing data quality control and genome alignment.
title: Usefulness of two dimensional magnetic resonance myelography (2D Myelo MR) for the exploration of the lumbar spine
Creators: name: Safa, Dominique
Publisher: name: European Congress of Radiology
Year: 2011
Subjects: subject: Myelography
subject: MR
subject: Neuroradiology spine
subject: Neuroradiology peripheral nerve
subject: Musculoskeletal spine

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal Information References
description: Learning objectives: PURPOSE -Toshow the usefulness of MR myelography (2D MYELO-MR sequence) for the exploration of the lumbar spine -Toillustrate normal and abnormal anatomy on MR myelograms -Toassess the impact of this sequence onindications for standard lumbar...
In silico targeting breast cancer biomarkers by applying rambutan (Nephelium lappaceum) phytocompounds
Creators: name: Parvizpour, Sepideh
name: Elengoe, Asita
name: Alizadeh, Effat
name: Razmara, Jafar
name: Shamsir, Mohd Shahir
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biochemistry
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Cancer

description: Worldwide, breast cancer is the leading type of cancer among women. Overexpression of various prognostic indicators, including nuclear receptors, is linked to breast cancer features. To date, no effective drug has been discovered to block the proliferation of breast cancer cells. This study has been designed to discover target-based small molecular-like natural drug candidates that have anti-cancer potential without causing any serious side effects. A comprehensive substrate-based drug design was carried out to discover the potential plant compounds against the target breast cancer biomarkers including phytochemicals screening, active site identification, molecular docking, pharmacokinetic (PK) properties prediction, toxicity prediction, and molecular dynamics (MD) simulation approaches. Twenty plant compounds extracted from the rambutan (Nephelium lappaceum) were obtained from PubChem Database; and screened against the breast cancer biomarkers including estrogen receptor (ER), progesterone receptor (PR), and androgen receptor (AR). The best docking interaction was chosen based on the higher binding affinity. Analyzing the pharmacokinetic properties and toxicity prediction results indicated that the fifteen selected plant compounds have good potency without toxicity and are safe for humans. Four phytochemicals with a higher binding affinity were chosen for each breast cancer biomarker to study their stability in interaction with the target proteins using MD simulation. Among the above compounds, Ellagic acid showed the high binding affinity against all three breast cancer biomarkers. Communicated by Ramaswamy H. Sarma
title: And...WHAT DO WE KNOW ABOUT THE EXCESSIVE LATERAL PRESSURE SYNDROME?
Creators: name: YLLERA CONTRERAS, ELNA
Publisher: name: European Congress of Radiology
Year: 2011
Subjects: subject: Trauma
subject: Inflammation
subject: Athletic injuries
subject: Diagnostic procedure
subject: MR
subject: Musculoskeletal system

description: Purpose Methods and Materials Results Conclusion References Personal Information
description: Purpose: The aim of this work is to review the "excessive lateral pressure syndrome" and analyze the knee anatomy and other patient's characteristics of a serie ofpatients presenting with focal inflamation in superior lateral Hoffa's pad, in order to...
Manual, 1873
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1873

description: [Universitätsbibliothek Basel]
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Juli 2019 HAN-Katalogisierungsregeln Minimalaufnahme nach Autopsie