cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Innovation in surgical training and its impact on healthcare
Creators: name: Lewis, Trystan
Publisher: name: Imperial College London
Year: 2012

description: Surgical training is currently in a state of flux, with dramatic changes in the way it is structured and delivered. The greatest challenges to surgical training have come from the advent of minimally invasive surgery in the 1990’s and more recently the reduction in a doctors working hours. This has led to a significant decrease in training opportunities that are available to the surgical trainee. Simulation has been heralded as an effective adjunct to surgical training whilst ensuring high standards of patient safety. This thesis aims to investigate the factors influencing current surgical training methods and whether simulation can be used to improve the effectiveness of surgical training in a cost efficient manner. The first part of this thesis investigates the impact that the reduction in working hours has had on surgical training, and whether the use of simulation can alleviate this. The reduction in working hours for doctors has led to a significant reduction in training opportunities. However, laboratory based simulation training can improve technical skills, provided it is used as part of a proficiency based technical skills curriculum. The second part of this thesis investigates the impact that innovations in surgery have had on surgical training, and whether simulator technology can advance at a similar rate. The introduction of single incision laparoscopic surgery provides further challenges for the surgical trainee, and it is clear that a novice laparoscopic surgeon needs further technical skills curriculum based training before entering the operating room. In addition, advancement in simulator technology now allows senior surgeons to learn advanced techniques in the skills laboratory. The final part of this thesis aims to assess the current costs of surgical training in the operating room, and whether simulation can improve operating room efficiency such that cost savings can be made. One of the main criticisms of simulation training is that it is expensive. However, the evidence in this thesis demonstrates that traditional training is also very expensive; and with prior training on simulation, operating times can be significantly reduced, providing sufficient cost savings that make simulation cost efficient. Simulation works. This is clear from the literature and from evidence provided by this thesis. Although simulation alone is not sufficient to train surgeons to operating room proficiency, it can provide a useful adjunct to surgical training. It allows trainees to train in the safety of skills laboratory, and shorten the learning curve in the operating room which in turn improves patient safety. If appropriate simulators are selected and used correctly, it can provide benefits to the healthcare system by reducing costs through an improvement in operating room efficiency.
Европейские рекомендации по профилактике сердечно-сосудистых заболеваний в клинической практике.Пересмотр 2016.pdf
Creators: name: Doe, Jonn
Publisher: name: figshare
Year: 2017
Subjects: subject: Cardiology
subject: 110201 Cardiology (incl. Cardiovascular Diseases)
subject: FOS: Clinical medicine

description: Европейские рекомендации по профилактике сердечно-сосудистых заболеваний в клинической практике.Пересмотр 2016.
Шестой совместный пересмотр клинических рекомендаций рабочей группой Европейского общества кардиологов и других обществ по профилактике сердечно-сосудистых заболеваний в клинической практике (составлен представителями десяти обществ и приглашенными экспертами)
Особый вклад в разработку рекомендаций внесла Европейская ассоциация сердечно-сосудистой профилактики и реабилитации (EACPR)

Оригинальная публикация: European heart Journal (2016) 37, 2315–2381,doi:10.1093/eurheartj/ehw106

Перевод и научное редактирование рекомендаций выполнены рабочей группой Российского кардиологического общества и Российского общества
профилактики неинфекционных заболеваний под председательством член-корр. РАН, проф. С.А. Бойцова.
Additional file 1 of Haemonchus contortus: siRNA mediated knockdown of matrix metalloproteinase 12A (MMP-12) results in reduction of infectivity
Creators: name: Naqvi, Muhammad Ali-ul-Husnain
name: Li, Hao
name: Gao, Wenxiang
name: Naqvi, Sana Zahra
name: Jamil, Tahseen
name: Aimulajiang, Kalibixiati
name: Xu, Lixin
name: Song, Xiaokai
name: Li, Xiangrui
name: Yan, Ruofeng
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Table S1. Specific small interfering RNAs of the MMP-12 gene. Table S2. Primer sequences of target genes related to quantitative real-time PCR.
Lehre - Lab - Research. Eine Mediathek im Spannungsfeld zwischen Lehre und Forschung
Creators: name: Lurk, Tabea
name: Enge, Jürgen
Publisher: name: Verein Deutscher Bibliothekarinnen und Bibliothekare
Year: 2017
Subjects: subject: Katalog
subject: Dokumentation
subject: künstlerische Forschung
subject: Web
subject: 020 - Bibliotheks- und Informationswissenschaft

description: Der Beitrag stellt den Laborcharakter der Mediathek der Hochschule für Gestaltung und Kunst FHNW Basel (HGK) vor und verdeutlicht anhand vom „integrierten Katalog“, wie der Einfluss der fortschreitenden Digitalisierung, die spezifischen lokalen und institutionellen Rahmenbedingungen sowie die wissenschaftspolitischen Anforderungen der künstlerischen und der Designforschung zur Profilbildung der Mediathek beitragen. Eine effiziente Kleinststruktur intern und eine grosse Offenheit für externe Anregungen und Kooperationen ermöglichen jene flexiblen und experimentellen Strukturen, die neben dem Normalbetrieb als Verbunds- und Fernleihbibliothek den spezifischen Charakter der Mediathek auszeichnen. The text presents the laboratory character of the Mediathek of the Academy of Design and Art FHNW Basel (HGK) and shows on the basis of the “integrated catalogue” how the ongoing digitization, the specific local and institutional framework and the academic policies, including artistic and design research, influence the profile of the Mediathek. An efficient internal microstructure and a great openness for external stimuli and collaborations enable flexible and experimental structures, which, in addition to the daily business as NEBIS Network library, characterize the typical nature of the Mediathek.
Additional file 1: of The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system
Creators: name: Manservisi, Fabiana
name: Lesseur, Corina
name: Panzacchi, Simona
name: Mandrioli, Daniele
name: Falcioni, Laura
name: Bua, Luciano
name: Manservigi, Marco
name: Spinaci, Marcella
name: Galeati, Giovanna
name: Mantovani, Alberto
name: Lorenzetti, Stefano
name: Miglio, Rossella
name: Andrade, Anderson
name: Kristensen, David
name: Perry, Melissa
name: Swan, Shanna
name: Chen, Jia
name: Belpoggi, Fiorella
Publisher: name: figshare
Year: 2019
Subjects: subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Figure S1. AGD index and AGD (Mean per litter) box plot (A) and dot plot (B). (DOCX 83 kb)
Activation of retinal glial (Müller) cells by extracellular ATP induces pronounced increases in extracellular H+ flux
Creators: name: Tchernookova, Boriana
name: Heer, Chad
name: Young, Marin
name: Swygart, David
name: Kaufman, Ryan
name: Gongwer, Michael
name: Shepherd, Lexi
name: Caringal, Hannah
name: Jacoby, Jason
name: Kreitzer, Matthew A
name: Malchow, Robert Paul
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: Uncategorized

description: Small alterations in extracellular acidity are potentially important modulators of neuronal signaling within the vertebrate retina. Here we report a novel extracellular acidification mechanism mediated by glial cells in the retina. Using self-referencing H+-selective microelectrodes to measure extracellular H+ fluxes, we show that activation of retinal Müller (glial) cells of the tiger salamander by micromolar concentrations of extracellular ATP induces a pronounced extracellular H+ flux independent of bicarbonate transport. ADP, UTP and the non-hydrolyzable analog ATPγs at micromolar concentrations were also potent stimulators of extracellular H+ fluxes, but adenosine was not. The extracellular H+ fluxes induced by ATP were mimicked by the P2Y1 agonist MRS 2365 and were significantly reduced by the P2 receptor blockers suramin and PPADS, suggesting activation of P2Y receptors. Bath-applied ATP induced an intracellular rise in calcium in Müller cells; both the calcium rise and the extracellular H+ fluxes were significantly attenuated when calcium re-loading into the endoplasmic reticulum was inhibited by thapsigargin and when the PLC-IP3 signaling pathway was disrupted with 2-APB and U73122. The anion transport inhibitor DIDS also markedly reduced the ATP-induced increase in H+ flux while SITS had no effect. ATP-induced H+ fluxes were also observed from Müller cells isolated from human, rat, monkey, skate and lamprey retinae, suggesting a highly evolutionarily conserved mechanism of potential general importance. Extracellular ATP also induced significant increases in extracellular H+ flux at the level of both the outer and inner plexiform layers in retinal slices of tiger salamander which was significantly reduced by suramin and PPADS. We suggest that the novel H+ flux mediated by ATP-activation of Müller cells and of other glia as well may be a key mechanism modulating neuronal signaling in the vertebrate retina and throughout the brain.
Verräterische Körpersprache
Creators: name: Freiermuth, Karin
Publisher: name: Docu Media Schweiz
Year: 2017
Subjects: subject: Befragungen
subject: Anhörungen
subject: Kommunikation
subject: Nonverbale Kommunikation
subject: 350 - Öffentliche Verwaltung

description: Verhandlungs- und Befragungssituationen beim Gericht oder bei der Polizei sind oft anspruchsvoll – insbesondere dann, wenn Personen aus unterschiedlichen Kulturkreisen beteiligt sind. Die verbale Kommunikation steht zwar im Zentrum, aber auch die Körpersprache kann wesentliche Hinweise geben.
Additional file 2: of The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system
Creators: name: Manservisi, Fabiana
name: Lesseur, Corina
name: Panzacchi, Simona
name: Mandrioli, Daniele
name: Falcioni, Laura
name: Bua, Luciano
name: Manservigi, Marco
name: Spinaci, Marcella
name: Galeati, Giovanna
name: Mantovani, Alberto
name: Lorenzetti, Stefano
name: Miglio, Rossella
name: Andrade, Anderson
name: Kristensen, David
name: Perry, Melissa
name: Swan, Shanna
name: Chen, Jia
name: Belpoggi, Fiorella
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Figure S2. First estrous box plot (A) and dot plot (B). (DOCX 33 kb)
Eupyrgota (Asipyrgota) Korneyev 2014, subgen. n.
Creators: name: Korneyev, V. A.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Pyrgotidae
Eupyrgota

description: Subgenus Asipyrgota V. Korneyev, subgen. n. T y p e s p e c i e s: Adapsilia flaviseta Aldrich, 1928: 2. D i a g n o s i s. The type species in its robust body and widely brown wing and legs, as well as female aculeus and male genitalia structure agrees with Eupyrgota s. str. differing by the structure of the apico-ventral portion of the oviscape (a “sucker” instead of hooks); the only species can be recognized also from. See also remarks for E. (A.) flaviseta . D e s c r i p t i o n. Moderately large, robust species; widely and uniformly darkened; scutellum with 3 pairs of setae; fore and mid trochanters of female without spiny or hooklike setulae; oviscape without ventral hooks, but with desclerotized U-shaped area and narrower oval sucker-like area inside, rimmed with narrow bare area (fig. 8, 11, 12). Male genitalia (fig. 8, 7 –9) similar to those in Eupyrgota (s. str.).
description: Published as part of Korneyev, V. A., 2014, Pyrgotid Flies Assigned To Apyrgota. I. New Species And Synonyms In Eupyrgota (S. Str.) (Diptera, Pyrgotidae), With The Description Of A New Subgenus, pp. 111-128 in Vestnik Zoologii 48 (2) on page 126, DOI: 10.2478/vzoo-2014-0012, http://zenodo.org/record/6403931
description: {"references": ["Aldrich, J. M. Five new parasitic flies reared from beetles in China and India // Proceedings of the U. S. National Museum. - 1928. - 74, N 8. - P. 1 - 7."]}
The Role of the GATA Transcription Factor Gaf1 in Nutrient Responses and Cellular Ageing
Creators: name: Gonzalez Gonoggia, Suam Ani
Publisher: name: University of East London
Year: 2022

description: The discovery of the biological bases of ageing continues to be one of the most fascinating challenges in modern science. Current efforts have narrowed the complexity of such task by focusing on mechanisms used by the cell to couple its physiology with environmental stimuli as they are often involved in the regulation of ageing. The Target of Rapamycin (TOR) have been proved to be a rheostat of nutritional status orchestrating cellular growth and homeostasis mainly through the regulation of transcriptional responses that remain to be understood. Recent studies unveiled novel functions of the evolutionarily conserved GATA transcription factor Gaf1 in nutrient sensing pathways and potentially in cellular ageing by regulating transcription downstream of TOR signalling. To elucidate these questions, the robust model organism Schizosaccharomyces pombe was used in this study due to its relevant similarity with higher eukaryotes and thoroughly described genetics. The experimental settings involved a combination of in silico analyses, fitness assessments, revivability assays, transcriptomics, mutagenesis, chemical-genetics, and interactome to further characterise functions of Gaf1. This study also contributed to the identification of candidate genes that promote longevity and mediate the resistance of mutant cells depleted of gaf1 gene to the TOR-kinase inhibitor torin1. The results indicate that upon TOR complex 1 (TORC1) inhibition, Gaf1 represses genes that induce protein translation (anabolism) and upregulates genes required for survival (catabolism) under adverse nutritional conditions downstream of TORC1.
Additional file 1 of Fecal microbiota transplantation improves chicken growth performance by balancing jejunal Th17/Treg cells
Creators: name: Ma, Ziyu
name: Akhtar, Muhammad
name: Pan, Hong
name: Liu, Qiyao
name: Chen, Yan
name: Zhou, Xinxin
name: You, Yingting
name: Shi, Deshi
name: Liu, Huazhen
Publisher: name: figshare
Year: 2023
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1: Supplementary Fig. S1. The fecal microbial composition of candidate donor chickens at the genus level. A. The fecal microbial composition of different donor chickens. B. The fecal microbial composition of the selected donor chicken at different time. HF represents female donor chickens with high body weight; HM represents male donor chickens with high body weight; LF represents female donor chickens with low body weight; LM represents male donor chickens with low body weight; W1-W4 represents one week, two weeks, three weeks, four weeks, respectively.
Role of telomere binding protein TRF2 in neural differentiation of human embryonic stem cells
Creators: name: Ovando Roche, Patrick
Publisher: name: Imperial College London
Year: 2013

description: Telomere repeat binding factor 2 (TRF2) is reported to be a key component of shelterin, a multi-protein complex that binds telomeric deoxyribonucleic acid (DNA) to protect chromosome ends and maintain genome stability. However, in recent years, TRF2 has been found to also bind non-telomeric regions and to act as a protein hub, interacting with a wide range of non-telomeric proteins and thus raising the possibility that it may serve functions independent of telomere maintenance. Despite the importance of TRF2, there is little information about how TRF2 is expressed during development and whether it could have an extratelomeric role in this process. Human embryonic stem cells (hESCs) derived from pre-implantation embryos are able to differentiate into most, if not all, tissues of the adult body, thereby provide a good cell model to tackle the problem. Given the abundance of TRF2 in the human brain and its potential for extratelomeric roles, this study focused on neural differentiation. TRF2 protein levels were found dramatically increased upon differentiation of hESCs to neural progenitor cells (NPCs) and these high levels, similarly to what is observed in vivo, were specific to the neural lineage. Gain and loss of function approaches revealed that exogenous expression of TRF2 in hESCs induced neural differentiation while, in contrast, TRF2 knockdown in NPCs drastically hindered their ability to terminally differentiate into neurons and glia. This enhancing neural function of TRF2 is achieved through the ability of TRF2 to inhibit the proteasomal degradation of REST4, an alternative splice variant of RE1-Silencing Transcription factor (REST), which alleviates REST repression over neural genes, hence consolidating neural progenitor identity and potency. This study identifies TRF2 as a novel component of neural differentiation, suggesting its importance in central nervous system development as well as in neurological disorders.
Kooperationsförderliche Kultur in Bauprojekten -Endlich Licht am Horizont?
Creators: name: Schulze, Hartmut
name: Mateescu, Magdalena
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2022
Subjects: subject: Zusammenarbeit im Bauwesen
subject: Projektkultur
subject: IPD
subject: 650 - Management

description: • Kooperative Projektkultur als Erfolgsfaktor in Bauprojekten • IPD besteht aus Strukturen und Prozessen, die aus einer kooperativen Haltung heraus entstanden sind und damit auch eine kooperative Projektkultur fördern • Die Etablierung einer kooperativen Projektkultur bedeutet ein «Verlernen» bisheriger erfolgreicher Handlungspraxen und Überzeugungen • Dafür braucht es neben einem Formalisierungsprozess über Mehrparteienverträge auch einen kontinuierlichen Sense-Making-Prozess
Structured Assessment of Competency in Polypectomy
Creators: name: Gupta, Sachin
Publisher: name: Imperial College London
Year: 2012

description: Currently, there is no national endoscopic database in England. Information regarding the volume of therapeutic endoscopic procedures such as polypectomy is obtained mainly from small prospective studies. We examined the Hospital Episode Statistics (HES) national database to assess the number of patients who underwent a therapeutic polypectomy for a primary diagnosis of a benign colorectal polyp over a 10 year period, as well as analysing outcomes from the first three years of bowel cancer screening at a single tertiary endoscopy centre. Despite the ubiquitous use of endoscopic snare polypectomy over the last four decades, there has been a void in formal training and assessment of polypectomy skills in the UK. We aimed to develop and validate an objective, structured assessment tool for assessing polypectomy competency in skilled accredited Bowel Cancer Screening endoscopists. This study led to the development of the DOPyS (Direct Observation of Polypectomy Skills) assessment tool. Validation and reliability of the DOPyS was demonstrated through assessment of polypectomy videos, performed by accredited Bowel Cancer Screening endoscopists, using Generalisability Theory (G theory). Construct validity of the DOPyS, and its ability to assess piecemeal Endoscopic Mucosal Resection, were determined through separate studies. The DOPyS validation studies highlighted variability in assessor scoring and DOPyS training days were held for Bowel Cancer Screening assessors in England, in order to align opinions prior to the implementation of the DOPyS into the Bowel Cancer Screening Accreditation Process in England. Finally, in an effort to provide a structure for improved polypectomy outcomes and referral systems, a study was performed to determine the difficulty ‘level’ of a polypectomy, based on polyp characteristics.
Additional file 3: of The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system
Creators: name: Manservisi, Fabiana
name: Lesseur, Corina
name: Panzacchi, Simona
name: Mandrioli, Daniele
name: Falcioni, Laura
name: Bua, Luciano
name: Manservigi, Marco
name: Spinaci, Marcella
name: Galeati, Giovanna
name: Mantovani, Alberto
name: Lorenzetti, Stefano
name: Miglio, Rossella
name: Andrade, Anderson
name: Kristensen, David
name: Perry, Melissa
name: Swan, Shanna
name: Chen, Jia
name: Belpoggi, Fiorella
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Figure S3. Male and female DHT box plot (A) and dot blot (B). (DOCX 86 kb)
title: Führt die passagere Einheilungsstörung der Mundschleimhaut nach Harnröhrenrekonstruktion zu einer erhöhten Rezidivstrikturrate?
Creators: name: Borisenkov, M.
name: Beier, J.
name: Keller, H.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Führt eine passagere Transplantateinheilungsstörung nach Urethrarekonstruktion (HR) zu vermehrtem Strikturrezidiven? Material und Methoden: Von 1333 konsek. Pat., nach HR mit Mundschleimhaut (OMG), 04/1994-03/2018, wurden Pat. über 18 J. nach einzeitiger[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
Supporting information 5
Creators: name: Forthman, Michael
name: Weirauch, Christiane
Publisher: name: figshare
Year: 2018
Subjects: subject: 60301 Animal Systematics and Taxonomy
subject: FOS: Biological sciences
subject: Evolutionary Biology

description: Parsimony ancestral state reconstruction of colour character 2 on the ML phylogram (tree converted to cladogram for visual). Terminal taxa coded as cryptic or metallic (black) or either aposematic or aposematic and metallic (blue).
Additional file 4: of The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system
Creators: name: Manservisi, Fabiana
name: Lesseur, Corina
name: Panzacchi, Simona
name: Mandrioli, Daniele
name: Falcioni, Laura
name: Bua, Luciano
name: Manservigi, Marco
name: Spinaci, Marcella
name: Galeati, Giovanna
name: Mantovani, Alberto
name: Lorenzetti, Stefano
name: Miglio, Rossella
name: Andrade, Anderson
name: Kristensen, David
name: Perry, Melissa
name: Swan, Shanna
name: Chen, Jia
name: Belpoggi, Fiorella
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Figure S4. Effects of glyphosate or Roundup Bioflow exposure on hormones in males (meanâ Âąâ SEM); coefficient of variation in square brackets. (DOCX 23 kb)
In Care and Digitally Savvy? Modern ICT use in Long-Term Care Institutions
Creators: name: Seifert, Alexander
name: Cotten, Shelia
Publisher: name: Taylor & Francis
Year: 2020

description: Although information and communication technologies (ICTs), such as smartphones, tablets, and the internet, have all become increasingly important in modern society, available studies on the adoption of ICTs have mostly focused on healthy and community-dwelling “young-old” adults. Relatively little is known about ICT use among long-term care residents, such as “old-old” adults, who often have various functional impairments and live in institutionalized settings. The study includes data on ICT use (TV, radio, computers, smartphones, tablets, and internet) among a large sample of 940 residents (mean age: 87.6 years) living in 20 retirement homes in Zurich, Switzerland. Twenty-one percent of residents reported using the internet, 13% used a smartphone, and 5% used a tablet. Younger older adults, those with more education, those with lower nursing-care levels, and those who reported being particularly interested in technology were more likely to own more than one ICT device. Compared with nonusers, internet users were more likely to be younger, better educated, and more interested in technology in general. Modern ICT usage has reached the long-term care sector and appears to play a significant role in many residents’ lives. Researchers should continue to examine the role of ICTs in the lives of older adults in general and for residents in long-term care in particular, given that this population is often ignored in studies of older adults and ICT use.
Supporting information 3
Creators: name: Forthman, Michael
name: Weirauch, Christiane
Publisher: name: figshare
Year: 2018
Subjects: subject: 60301 Animal Systematics and Taxonomy
subject: FOS: Biological sciences
subject: Evolutionary Biology

description: Parsimony ancestral state reconstruction of colour character 1 on the ML phylogram (tree converted to cladogram for visual). Terminal taxa coded as cryptic (black) or either aposematic, metallic, or aposematic and metallic (blue).
Cohesin dynamics during meiotic prophase
Creators: name: Testori, Sarah
Publisher: name: Imperial College London
Year: 2013

description: For faithful segregation during meiosis, chromosomes must be physically linked by both sister chromatid cohesion (SCC), provided by cohesin, and at least one crossover (CO). In mitosis, cohesin is dynamically associated with chromatin and this has been shown to be crucial for the repair of DSBs. Although DSBs are purposely made to start meiotic recombination, it is unknown if meiotic cohesin is dynamically associated with chromatin. However, cohesin loss or degradation is thought to be involved in the high incidence of aneuploidy observed in human eggs. In Caenorhabditis elegans (C. elegans), the cohesin loader SCC-2 remains associated with the axial element of meiotic chromosomes following the completion of S-phase, hinting that cohesin may be reloaded during meiotic prophase. To confirm this, I investigated if depleting SCC-2 by RNAi after entrance into meiotic prophase had an effect on cohesin association with chromosomes. This revealed loss of the cohesin subunit REC-8 from late prophase nuclei, suggesting that without reloading cohesin is removed from chromatin. Furthermore, scc-2 RNAi also resulted in the impairment of chiasmata, raising the possibility that cohesin reloading plays a role in CO formation or in chiasma maintenance. Two key mediators of cohesin removal are known to operate during the G2 phase of the mitotic cell cycle: the presence of DSBs and the cohesion anti-establishment factor Wapl1. Here I show for the first time that WAPL-1 modulates the cohesiveness of complexes containing the meiosis-specific kleisins COH-3 and COH-4. Furthermore, cohesin complexes containing different kleisins are differentially modulated by DSBs, and only REC-8-containing cohesin complexes can undertake the repair of DNA damage. Finally, I have developed several genetic tools to allow the visualization of cohesin turnover during meiosis. These findings show the exceptional complexity of cohesin dynamics during meiotic prophase, as well as demonstrating roles for cohesin outside of the provision of SCC.
Gemeindefinanzen verstehen - Rodersdorf
Creators: name: Sutter, Emilio
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2018

description: Bei diesem Anlass ging es darum, interessierten Gemeindepolitikerinnen und -politikern, Behördenmitgliedern sowie Bürgerinnen und Bürgern im Referat die aktuelle Umsetzung des Harmonisierten Rechnungslegungsmodells 2 (HRM2) in der Gemeinde Rodersdorf aufzuzeigen. Im Anschluss an das Referat fand eine moderierte Diskussion zu dieser Thematik statt.
Additional file 5: of The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system
Creators: name: Manservisi, Fabiana
name: Lesseur, Corina
name: Panzacchi, Simona
name: Mandrioli, Daniele
name: Falcioni, Laura
name: Bua, Luciano
name: Manservigi, Marco
name: Spinaci, Marcella
name: Galeati, Giovanna
name: Mantovani, Alberto
name: Lorenzetti, Stefano
name: Miglio, Rossella
name: Andrade, Anderson
name: Kristensen, David
name: Perry, Melissa
name: Swan, Shanna
name: Chen, Jia
name: Belpoggi, Fiorella
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Figure S5. Effects of glyphosate or Roundup Bioflow exposure on hormones in females (meanâ Âąâ SEM); coefficient of variation in square brackets. (DOCX 23 kb)
Supplementary material 6
Creators: name: Forthman, Michael
Publisher: name: figshare
Year: 2017
Subjects: subject: 60301 Animal Systematics and Taxonomy
subject: FOS: Biological sciences
subject: Evolutionary Biology

description: BayesTraits MultiState ML ancestral state reconstruction of colour character 2 on the ML phylogram (tree converted to cladogram for visual). Terminal taxa coded as cryptic or uniform metallic (black) or aposematic or aposematic and metallic (blue). Pie charts at select nodes show probability values from the ML reconstruc- tions; branches are coloured to reflect the highest probability of a colour state at that branch.
Supporting information 1
Creators: name: Forthman, Michael
name: Weirauch, Christiane
Publisher: name: figshare
Year: 2018
Subjects: subject: 60301 Animal Systematics and Taxonomy
subject: FOS: Biological sciences
subject: Evolutionary Biology

description: Species of Ectrichodiinae that were assigned to colouration categories (i.e., cryptic, aposematic, uniform metallic, or aposematic and metallic) by five independent observers. Those without an (*) were based on at least one voucher specimen. (*) indicates live images additionally available. Species in bold are those in which a majority opinion was not achieved by the independent observers, with ties broken by the senior author’s assignment that was made prior to surveying the observers.
IMPACT OF WORK LIFE BALANCE OF EMPLOYEES IN HOSPITAL INDUSTRY IN INDIA- A CASE STUDY OF APOLLO HOSPITALS, VISAKHAPATNAM
Creators: name: Dr. G Kanaka Mahalakshmi
name: Shoba Rani Pilla
Publisher: name: Zenodo
Year: 2024
Subjects: Work-Life Balance, Job Satisfaction, Hospital, Relationship, Family.

description: Abstract

Purpose: The main purpose of this study is to identifying Work Life Balance of Employees in Hospital Industry in India- A Case Study of Apollo Hospitals, Visakhapatnam of Andhra Pradesh. Design/Methodology/Approach: The researcher had focused his attention on aimed to explore the role of perceived work-life balance and job satisfaction in developing commitment among hospital employees. In addition to that, gender difference is also taken into consideration to draw concrete conclusion. The study is quantitative in nature. Based on the literature review it is proposed that work-life balance and satisfaction will be significantly contributing in developing commitment among the chosen respondents. Results revealed a moderate level of work-life balance, job satisfaction and organizational commitment among the chosen employees. Significant relationship is found between work-life balance and job satisfaction. Originality/Value.  In this study we used in Descriptive Research tools to be used like ANOVA, for Work interfering family life and family interfering work life are found positively related with organizational commitment. Male and female respondent are found significantly different in their level of commitment, perceived work interfering family life and perceived family interfering work life. Findings: Work-life balance is about finding the right balance between one’s work and one’s life (i.e. life outside work) and about feeling comfortable with both work and non- work commitments. Many people find it difficult to manage their time in a way that is healthy for their work as well as for their personal life (Vlems, 2005). This may not be because they are poor at time management, but largely because a good part of the time is not theirs. It belongs to the organization. But do employees have to crowd out other activities that are important in their lives just to satisfy the boss? Achieving the right balance is something very personal, because we all have different priorities in life.
Investigating the motor-sensory learning of foreign speech
Creators: name: Simmonds, Anna Jane
Publisher: name: Imperial College London
Year: 2012

description: This thesis presents an investigation of bilingualism as a motor learning skill, with success ultimately measured in terms of strength of a foreign accent, in contrast to the many studies of bilingualism in terms of linguistic competence. My research used functional magnetic resonance (fMRI) imaging to investigate feedforward (motor) and feedback (auditory and somatosensory) systems involved in the production of foreign speech and how these systems are modulated by proficiency levels. I investigated the function of the frontal operculum and the temporo-parietal junction (TPJ) – planum temporale (posterior auditory association cortex) and parietal operculum (somatosensory association cortex) – during speech. The frontal operculum, strongly lateralised to the left, has been associated with speech since Broca performed his classic post mortem lesion-deficit analysis. Interest in the TPJ has arisen because of recent publications proposing the posterior half of the left planum temporale (± adjacent parietal operculum) as a ‘sensorimotor interface’ for speech production. My research compared activity within the frontal operculum and the TPJ during overt and covert speech. A second fMRI study examined retrospective proficiency based on existing language skills in people with English as a foreign language who were scanned during speech production in their native language and in English. A third fMRI study manipulated proficiency by training monolingual native English participants in the production of foreign speech sounds, with scanning pre- and post-training. This allowed measures of changes in activity (indicating rapid plasticity) following a short period of behavioural training in articulating novel foreign speech sounds. Training effects were observed predominantly in the striatum, and further analyses indicated that striatal activity in vocal learning is modulated by proficiency.
Studies of DNA Structures Linking Sister Chromatids, the Proteins that Regulate them, and their Impact on Segregation During Anaphase
Creators: name: Sen, Nicholas
Publisher: name: Imperial College London
Year: 2013

description: Type IIA topoisomerases have long been attributed the ability to simplify DNA topology – supercoils, knots and catenanes – far beyond their thermodynamic equilibrium. Such activity makes clear biological sense, however topology of a DNA molecule is a global attribute, and type IIA topoisomerases are capable only of recognizing local structures that constitute workable substrates. In the case of type IIA topoisomerases local DNA juxtapositions embody these substrates. To be able to reliably simplify DNA topology, without by chance increasing its complexity, these enzymes would be required to have the ability to discern some aspect of the global topology from the interactions with these local juxtaposed DNA substrates. Previous studies have generated computer simulations of juxtaposed chromatin segments whereby information regarding the global topological state is somehow communicated to the enzyme. These models vary in nature, from protein- centric models involving the forced introduction of ‘kinks’ into the DNA, to DNA-centric models, which suggest alterations in chirality of crosses are suggestive of the topological state of the molecule, and thus all local DNA juxtapositions encode details of higher order structure. For the system to function in this manner, information ‘encoded’ in one DNA juxtaposition would have to become altered when other distinct substrates are acted upon. This study aimed to investigate whether S. cerevisiae topoisomerase II is capable of enforcing directional alteration of the ratio of catenated plasmid dimers to monomers in vivo. Systems that artificially generate increased proximity between plasmids were tested and yielded inconclusive results pertaining to this question. Existing evidence has shown a shift in the supercoiling state from (-) to (+) occurs at the metaphase to anaphase transition, and that this forces Top2 to resolve catenated nodes in favour of relaxing supercoils, however this transition would gain credence in the case that prior to this event Top2 was able to concatenate DNA, and that the probability of this occurring was equal to the likelihood of catenated nodes becoming resolved. Further investigation of this transition has revealed the requirement for Cdc5, and Scc1. Additionally the localization of the Condensin complex was analyzed to gain a better understanding of how transition factors are regulated.
Endoscopic Laser Speckle Contrast Analysis for Tissue Perfusion
Creators: name: Song, Lipei
Publisher: name: Imperial College London
Year: 2012

description: Laser speckle contrast analysis (LASCA), as a method of measuring blood flow speed and tissue perfusion, is a full field imaging technique requiring simple configurations and data processing, which is important for the application in real time in vivo. But LASCA is sensitive to changes in environmental factors. The application in vivo is also limited to superficial detection due to the limitation of the light penetration depth. Therefore this thesis aims to develop an endoscopic LASCA system to extend the access to internal detection and explore the relationship between the contrast and experimental parameters. Firstly the relationship between the contrast and speckle size, flow mode, quantity of stationary scatterers and the signal intensity were investigated. Theoretical models for the relationship between the contrast and the mean intensity of the speckle pattern were deduced and the correction methods were introduced to correct the contrast bias due to the intensity difference. Then a flexible single wavelength endoscopic laser speckle contrast analysis system (ELASCA) was developed using a leached fibre image guide (LFIG). A Butterworth filter and defocus were used to remove the fibre pattern to retrieve the contrast images. This system and the data processing methods were used on a customized phantom demonstrating that this ELASCA system can detect the flow speed changes in an imaging domain. Afterwards a dual-wavelength ELASCA was developed for functional imaging of the blood circulation. The test on a human fingertip and rabbit uterine blood vessels show that this system can monitor the change of blood flow speed and the oxygen saturation introduced by occlusion, in addition to the cardiac pulse and respiration rate. Then a novel application of LASCA to visualize the ultrasound pressure field and the propagation of the shear wave is presented for the application of locating area of interest (AOI) and detecting tissue variation.
Functional characterisation of the genomes of rat models of human diseases
Creators: name: Atanur, Santosh
Publisher: name: Imperial College London
Year: 2013

description: Large numbers of inbred laboratory rat strains have been developed in the past 100 years by phenotype-driven selective breeding for the study of a range of disease phenotypes. The spontaneously hypertensive rat (SHR) is the most widely studied animal model of hypertension. The SHR Genome was sequenced with 10.7X coverage, and ~4 million genomic variants between SHR and the BN reference genome were identified. Analysis of the SHR genome revealed that cis expression quantitative trait locus genes were significantly enriched for genomic variants and that the genes harboring major mutations were enriched for ion transport and plasma membrane localization. To gain insights into the evolutionary pressures acting on inbred rat strains during phenotype driven selective breeding and, in turn, the molecular basis underlying disease phenotypes, the genomes of an additional 27 rat strains were sequenced, including 11 models of hypertension, diabetes and insulin resistance along with their respective control strains. A total of 9,665,340 single nucleotide variants (SNVs), 3,502,117 indels and 555,419 structural variants and 897,217 copy number variants were identified across the 28 rat strains. Using SNVs, 96 distinct artificial selective sweeps were identified in the disease models, a significant proportion of which were co-localised with physiological quantitative trait loci mapped previously in respective rat strains. Further, clusters of genes that had co-evolved in the disease models were identified, human orthologous of which were enriched for the genes implicated in the human genome wide association studies for cardiovascular and metabolic phenotypes. These analyses identified both known and new genes involved in the renin-angiotensin pathway, in ion transport and in regulation of oxidative stress. These genes may underlie disease phenotypes manifested by the rat strains thus providing novel insights into molecular mechanisms underlying complex traits in these rat strains.
Supplementary material 3
Creators: name: Forthman, Michael
name: Weirauch, Christiane
Publisher: name: figshare
Year: 2017
Subjects: subject: 60301 Animal Systematics and Taxonomy
subject: FOS: Biological sciences
subject: Evolutionary Biology

description: Parsimony ancestral state reconstruction of colour character 1 on the ML phylogram (tree converted to cladogram for visual). Terminal taxa coded as cryptic (black) or either aposematic, metallic, or aposematic and metallic (blue).
Wie kann die interne Evaluation für die konkrete Schul- und Unterrichtsentwicklung nutzbar(er) gemacht werden?
Creators: name: Härri, Roland
Publisher: name: Carl Link
Year: 2018
Subjects: subject: Evaluation
subject: Schulentwicklung
subject: Qualitätsmanagement
subject: 370 - Erziehung, Schul- und Bildungswesen

description: Als eine Form interner Schulevaluation zielt seiEval darauf, Schulentwicklungsvorhaben von vorne herein mit einer begleitenden Evaluation zu planen und umzusetzen. Entscheidend sind die Verarbeitungsprozesse der Schule, die zwischen den Evaluationsergebnissen und der darauffolgenden evaluationsbasierten Unterrichts- und Schulentwicklung stattfinden.
Discontinuing Psychiatric Medications: A Survey of Long-Term Users
Creators: name: , Live
Publisher: name: figshare
Year: 2017
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 111005 Mental Health Nursing

description: This is the first publication out of this study, and contains a descriptive report of the data as well as initial impressions from the study team.
Modelling genetic and genomic interactions underlying gene expression and complex traits
Creators: name: Langley, Sarah Raye
Publisher: name: Imperial College London
Year: 2012

description: This study focuses on integrating and applying computational techniques for modelling quantitative traits and complex diseases, such as hypertension and diabetes, using the rat model system and translating the findings to humans. Complex disease traits are heritable, highly polygenic, and influenced by environmental factors. Human studies, like Genome Wide Association Studies (GWAS), have identified many genetic determinants underlying these traits but have provided little information about the functional effects of these variants and mechanisms regulating the disease. This study takes a systems-level approach for looking at the genetic regulation of complex traits in the rat by analysing multiple phenotypes, genomewide genetic variation and gene expression data in multiple tissues. I integrated these multi-modality datasets in the BXH/HXB rat Recombinant Inbred (RI) lines, an established model of the human metabolic syndrome, to identify candidate genes, pathways and networks associated with complex disease phenotypes. I evaluated methods for Expression Quantitative Trait Locus (eQTL) analysis and used sparse Bayesian regression approaches to map eQTLs in the RI lines, delineating a new, large eQTL data resource for the rat genetic community. I have also developed and applied signal processing and time series analysis methods to physiological traits to extract more detailed indices of blood pressure, and integrated these with genetic, expression and eQTL data to inform on the regulation of these traits. Then, using publicly available data, I used comparative genomics approaches to elucidate a set of genes and pathways that can play a role in human diseases. This study has provided a valuable resource for future work in the rat, by means of new eQTLs in multiple tissues, and physiological time series phenotypes and approaches. This has enabled an integrative analysis of these data to give new insights into the regulation of complex traits in rats and humans.
Additional file 1: of Comparative proteomic analysis provides new insight into differential transmission of two begomoviruses by a whitefly
Creators: name: Zhao, Jing
name: Chi, Yao
name: Zhang, Xin-Jia
name: Lei, Teng
name: Wang, Xiao-Wei
name: Liu, Shu-Sheng
Publisher: name: figshare
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Evolutionary Biology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Table S1. Primers used in this study. Table S2. DEPs identified in the comparison of TYLCV-infected vs. un-infected. Table S3. DEPs identified in the comparison of PaLCuCNV-infected vs. un-infected. Table S4. DEPs identified in the comparison of TYLCV-infected vs. PaLCuCNV-infected. (DOCX 61 kb)
title: Eignet sich die Mundschleimhaut zur Rekonstruktion peniler Harnröhrenstrikturen?
Creators: name: Borisenkov, M.
name: Beier, J.
name: Keller, H.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Wir verglichen die Strikturrezidivrate (SR) nach Urethrarekonstruktion (HR) mittels Mundschleimhaut (OMG) im bulbären und penilen Bereich. Material und Methoden: Von 1333 konsekutiven Pat., 04/1994-03/2018, wurden die Pat. über 18 J. nach einzeitiger HR mit OMG ohne[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie