cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 3: of Insulin-like growth factor receptor and sphingosine kinase are prognostic and therapeutic targets in breast cancer
Creators: name: Ochnik, Aleksandra
name: Baxter, Robert
Publisher: name: figshare
Year: 2017
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Prognostic survival outcomes in relation to IGF1R protein expression in HER2 and PR-positive and negative breast cancer tissues. Kaplan-Meier analysis was performed to measure the overall survival (OS) following stratification for high vs. low IGF1R protein expression, stratified for HER2 and PR expression: A. IGF1R (HER2-negative); B. IGF1R (HER2-positive); C. IGF1R (PR-negative) and D. IGF1R (PR-negative) as described under Methods. (DOCX 264Â kb)
Heterogeneous nucleation of catalyst-free InAs nanowires on silicon
Creators: name: Gomes, U. P.
name: Ercolani, D.
name: Zannier, V.
name: Battiato, S.
name: Ubyivovk, E.
name: Mikhailovskii, V.
name: Murata, Y.
name: Heun, S.
name: Beltram, F.
name: Sorba, L.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We report on the heterogeneous nucleation of catalyst-free InAs nanowires on Si (111) substrates by chemical beam epitaxy. We show that nanowire nucleation is enhanced by sputtering the silicon substrate with energetic particles. We argue that particle bombardment introduces lattice defects on the silicon surface that serve as preferential nucleation sites. The formation of these nucleation sites can be controlled by the sputtering parameters, allowing the control of nanowire density in a wide range. Nanowire nucleation is accompanied by unwanted parasitic islands, but by careful choice of annealing and growth temperature allows to strongly reduce the relative density of these islands and to realize samples with high nanowire yield.
title: Titre_Méthode progressive applicable au dressage du cheval de troupe, d'officier et d'amateur
Creators: name: AmateurS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Titre
Pseudomonas aeruginosa flagellum is critical for invasion, cutaneous persistence and induction of inflammatory response of skin epidermis
Creators: name: Garcia, Magali
name: Morello, Eric
name: Garnier, Julien
name: Barrault, Christine
name: Garnier, Martine
name: Burucoa, Christophe
name: Lecron, Jean-Claude
name: Si-Tahar, Mustapha
name: Bernard, François-Xavier
name: Bodet, Charles
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Pseudomonas aeruginosa, an opportunistic pathogen involved in skin and lung diseases, possesses numerous virulence factors, including type 2 and 3 secretion systems (T2SS and T3SS) and its flagellum, whose functions remain poorly known during cutaneous infection. Using isogenic mutants deleted from genes encoding each or all of these three virulence factors, we investigated their role in induction of inflammatory response and in tissue invasiveness in human primary keratinocytes and reconstructed epidermis. Our results showed that flagellum, but not T2SS and T3SS, is involved in induction of a large panel of cytokine, chemokine, and antimicrobial peptide (AMP) mRNA in the infected keratinocytes. Chemokine secretion and AMP tissular production were also dependent on the presence of the bacterial flagellum. This pro-inflammatory effect was significantly reduced in keratinocytes infected in presence of anti-toll-like receptor 5 (TLR5) neutralizing antibody. Bacterial invasion of human epidermis and persistence in a mouse model of sub-cutaneous infection were dependent on the P. aeruginosa flagellum. We demonstrated that flagellum constitutes the main virulence factor of P. aeruginosa involved not only in early induction of the epidermis inflammatory response but also in bacterial invasion and cutaneous persistence. P. aeruginosa is mainly sensed by TLR5 during the early innate immune response of human primary keratinocytes.
Political connections, legal liability and auditor behaviours: evidence from China
Creators: name: He, Ku
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: External auditing provides reasonable assurance to accounting information quality and alleviates the agency problem in corporations. In China, after the re-establishment of the external auditing profession in the 1980s, the auditing profession developed significantly and came to play an important role in the capital market. However, the institutional mechanisms are still relatively weak and underdeveloped in China, Therefore, this thesis is concerned about whether and how legal liability and political connections can influence auditor behaviour in the Chinese setting.
Strong deflection gravitational lensing by a modified Hayward black hole
Creators: name: Zhao, Shan-Shan
name: Xie, Yi
Publisher: name: arXiv
Year: 2017
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: A modified Hayward black hole is a nonsingular black hole. It is proposed to form when the pressure generated by quantum gravity can stop matter's collapse as the matter reaches Planck density. Strong deflection gravitational lensing happening nearby its event horizon might provide some clues of these quantum effects in its central core. We investigate observables of the strong deflection lensing, including angular separations, brightness differences and time delays between its relativistic images, and estimate their values for the supermassive black hole in the Galactic center. We find that it is possible to distinguish the modified Hayward black hole from a Schwarzschild one, but it demands very high resolution beyond current stage.
description: 10 pages, 1 figure
Additional file 2: of Customer satisfaction of Vietnam Airline domestic service quality
Creators: name: Khanh, Giao Ha Nam
Publisher: name: figshare
Year: 2017
Subjects: subject: Medicine
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Regression assumption test. (DOCX 170Â kb)
Comment l'intégration des principes de neurogaming dans la conception des jeux vidéo peut-elle influencer positivement l'expérience utilisateur ?
Creators: name: Pelissier, Alexis
name: Gbaguidi, Mickaël
name: Rabiller, Alexis
name: Lainé, Tristan
Publisher: name: Zenodo
Year: 2024
Subjects: subject: Neurogaming
subject: Jeux vidéo
subject: Neurosciences
subject: FOS: Clinical medicine

description: Ce document examine comment l'intégration des principes de neurogaming peut améliorer l'expérience utilisateur dans les jeux vidéo. Le neurogaming combine neurosciences et technologies de jeu pour créer des interactions immersives et personnalisées. Il explore les bases de la neuroscience, les technologies utilisées, et leur application dans les jeux vidéo. Le document présente également des études de cas, analyse les retours des utilisateurs, et discute des défis technologiques et éthiques, ainsi que des perspectives futures dans le domaine du jeu vidéo et au-delà.

 

 

Auteurs

Alexis Pelissier

Mickaël Gbaguidi

Alexis Rabiller

Tristan Lainé
Wide-band Profile Domain Pulsar Timing Analysis
Creators: name: Lentati, L.
name: Kerr, M.
name: Dai, S.
name: Hobson, M. P.
name: Shannon, R. M.
name: Hobbs, G.
name: Bailes, M.
name: Bhat, N. D. Ramesh
name: Burke-Spolaor, S.
name: Coles, W.
name: Dempsey, J.
name: Lasky, P. D.
name: Levin, Y.
name: Manchester, R. N.
name: Oslowski, S.
name: Ravi, V.
name: Reardon, D. J.
name: Rosado, P. A.
name: Spiewak, R.
name: van Straten, W.
name: Toomey, L.
name: Wang, J.
name: Wen, L.
name: You, X.
name: Zhu, X.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We extend profile domain pulsar timing to incorporate wide-band effects such as frequency-dependent profile evolution and broadband shape variation in the pulse profile. We also incorporate models for temporal variations in both pulse width and in the separation in phase of the main pulse and interpulse. We perform the analysis with both nested sampling and Hamiltonian Monte Carlo methods. In the latter case we introduce a new parameterisation of the posterior that is extremely efficient in the low signal-to-noise regime and can be readily applied to a wide range of scientific problems. We apply this methodology to a series of simulations, and to between seven and nine yr of observations for PSRs J1713$+$0747, J1744$-$1134, and J1909$-$3744 with frequency coverage that spans 700-3600MHz. We use a smooth model for profile evolution across the full frequency range, and compare smooth and piecewise models for the temporal variations in DM. We find the profile domain framework consistently results in improved timing precision compared to the standard analysis paradigm by as much as 40% for timing parameters. Incorporating smoothness in the DM variations into the model further improves timing precision by as much as 30%. For PSR J1713+0747 we also detect pulse shape variation uncorrelated between epochs, which we attribute to variation intrinsic to the pulsar at a level consistent with previously published analyses. Not accounting for this shape variation biases the measured arrival times at the level of $\sim$30ns, the same order of magnitude as the expected shift due to gravitational-waves in the pulsar timing band.
description: 22 pages, submitted to MNRAS
title: ADCO, Cinquième cartulaire de Saint-Étienne de Dijon (1664), Cart. 28 (G 132), 258 folios, f. 00421
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire

description: Cinquième cartulaire de Saint-Étienne de Dijon (1664), Archives départementales de la Côte-d'Or, Cart. 28 (G 132), 258 folios, f. 00421, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cinquième cartulaire de Saint-Étienne de Dijon (1664), Archives départementales de la Côte-d'Or, Cart. 28 (G 132), 258 folios, f. 00421, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Additional file 1: of A partially supervised physical activity program for adult and adolescent survivors of childhood cancer (SURfit): study design of a randomized controlled trial [NCT02730767]
Creators: name: Rueegg, Corina
name: Kriemler, Susi
name: Zuercher, Simeon
name: Schindera, Christina
name: Renner, Andrea
name: Hebestreit, Helge
name: Meier, Christian
name: Eser, Prisca
name: Weid, Nicolas Von Der
Publisher: name: figshare
Year: 2017
Subjects: Medicine
Biotechnology
Science Policy

description: SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documents. Contains the SPIRIT Checklist in its original template. The table lists all the recommended items that should be addressed in a clinical trial study protocol and indicates the page numbers where the respective item is described. (DOCX 65 kb)
Fluorescent nanoparticles: a probe to study the molecular trafficking of somatostatin
Creators: name: Sreenivasan, Varun Kumaraswamy Annayya Chetty
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Somatostatin is a biological molecule that serves important physiological functions in a human body, including the regulation of blood pressure and growth. These functions are furnished by a set of complex interactions between somatostatin and other participating biomolecules. The main goal of this Ph.D. project was to develop tools based on fluorescent nanoparticles that can report on these interactions at a molecular scale. Fluorescent nanoparticles offer the advantages of protein-comparable size, high detection sensitivity, biocompatibility, and physical, chemical and photophysical stabilities, in comparison with many conventional molecular probes. Three key milestones of this project included: (i) Elucidating and harnessing the interactions of nanoparticles with biological molecules and cells. In particular, two types of nanoparticle-cell interactions were investigated: non-specific interactions, characterized by poorly controllable parameters, such as nanoparticle size, charge and surface chemical groups; and specific interactions, characterized by a precise communication protocol of a particular cell type with a nanoparticle surface, grafted with a specific ligand. As a result of these investigations, the non-specific interaction channel was inhibited, whereas the somatostatin-specific interaction channel was activated. (ii) Development of a universal biofunctionalization methodology to assemble robust, versatile nanoparticular and biomolecular modules. Specifically, an affinity molecular pair based biofunctionalization platform was developed, which allowed a 'pot-mix' procedure to attach biomolecules onto nanoparticle surfaces. (iii) Design, synthesis and demonstration of a biologically active nanoparticle-somatostatin complex. This included two stages: characterization of the receptor-binding activity of somatostatin ligands loaded with a fluorescent tag, such as a red fluorescent protein; and introduction and testing of a two-stage nanoparticle biofunctionalization and receptor-mediated internalization procedure, which allowed to circumvent the loss of the somatostatin-nanoparticle biological activity. Identication and rectification of the loss of biological activity has been one of the core accomplishments. Such an assembly has been demonstrated to be suitable for observing the somatostatin-cell interactions. A comprehensive, multi-stage program for tagging fluorescent nanoparticles to a targeting biomolecule has been incepted and carried out to a successful completion. The prospects of deploying fluorescent nanoparticle labeling technology is far-reaching, ranging from in vivo investigations of neuronal machinery to tumor diagnosis and treatment. This work is believed to provide a tangible contribution to nanotechnology and life sciences.
Clustering in vibrated monolayers of granular rods
Creators: name: Gonzalez-Pinto, Miguel
name: Borondo, Florentino
name: Martinez-Raton, Yuri
name: Velasco, Enrique
Publisher: name: arXiv
Year: 2017
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We investigate the ordering properties of vertically-vibrated monolayers of granular cylinders in a circular container at high packing fraction. In line with previous works by other groups, we identify liquid-crystalline ordering behaviour similar to that of two-dimensional hard rectangular particles subject to thermal equilibrium fluctuations. However, due to dissipation, there is a much stronger tendency for particles to cluster into parallel arrangements in the granular system. These clusters behave as a polydisperse mixture of long life-time `superparticles', and some aspects of the system behaviour can be understood by applying mean-field theories for equilibrium hard rectangles, based on two-body correlations, to these `superparticles'. Many other features of the granular system are different: (i) For small particle length-to-breadth ratio $κ$, we identify tetratic ordering at moderate packing fractions and smectic fluctuations at higher packing fractions, with no sharp transition between the two states. Both types of ordering can be explained in terms of clustering. (ii) For large $κ$, strong clustering precludes the stabilisation of a uniaxial nematic state, and the system exhibits a mixture of randomly-oriented clusters which, as packing fraction is increased, develops into states with smectic fluctuations, again through a diffuse transition. (iii) Vorticity excitations of the velocity field compete with smectic ordering, causing dynamic fluctuations and the absence of steady states at high densities; the tetratic state, by contrast, is very stiff against vorticity, and long-standing steady states, spatially and orientationally homogeneous except for four symmetrical defects located close to the wall, can be observed.
description: 13 pages, 15 figures
How do business models evolve in practice?: a complex-adaptive perspective
Creators: name: Rolfe, Iain
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Firms in the high-technology sector must navigate an environment that is dynamic and fast-moving. It is an environment that displays continual disequilibrium and witnesses regular shocks. In such a discordant environment, traditional top-down modes of strategic planning struggle to generate sufficient flexibility and speed of change necessary for a firm to maintain environmental fit over time. Instead, to coevolve with its environment a firm, and in particular, its business model(s) must adapt constantly. To achieve this, significant decision-making must necessarily be located in the operational layers of the firm. To understand how the resulting multitude of small decisions result in change(s) to the firm’s business model, I conduct a multiple method case study on Cisco as a kind of phenotype in the high-technology sector. Cisco is a firm whose business models have the capacity to change themselves in response to external stimuli. Through a strategy-as-practice lens, I establish that Cisco’s business models exhibit characteristics of complex adaptive systems and function analogously to them. I suggest the notion of a complex adaptive business model is theoretically located in evolutionary economics and emergent strategy instead of neoclassical economics and mainstream strategy. Consequently, I recommend the firm perceive itself as the facilitator and orchestrator of the business model rather than the controller of it. To guide the business model, I recommend the firm embrace an overall strategic framework that provides high-level rules and boundaries but otherwise allows the business model to develop freely. Such freedom has both positive and negative implications. For firms housing or seeking to establish a complex adaptive business model, I highlight the firm’s own high-level purpose must be clearly resolved and cultural and structural adjustments inside the firm be made.
Inhibition of Pseudomonas aeruginosa secreted virulence factors reduces lung inflammation in CF mice
Creators: name: Sandri, Angela
name: Ortombina, Alessia
name: Boschi, Federico
name: Cremonini, Eleonora
name: Boaretti, Marzia
name: Sorio, Claudio
name: Melotti, Paola
name: Bergamini, Gabriella
name: Lleo, Maria
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Background: Cystic fibrosis (CF) lung infection is a complex condition where opportunistic pathogens and defective immune system cooperate in developing a constant cycle of infection and inflammation. The major pathogen, Pseudomonas aeruginosa, secretes a multitude of virulence factors involved in host immune response and lung tissue damage. In this study, we examined the possible anti-inflammatory effects of molecules inhibiting P. aeruginosa virulence factors. Methods: Pyocyanin, pyoverdine and proteases were measured in bacterial culture supernatant from different P. aeruginosa strains. Inhibition of virulence factors by sub-inhibitory concentrations of clarithromycin and by protease inhibitors was evaluated. Lung inflammatory response was monitored by in vivo bioluminescence imaging in wild-type and CFTR-knockout mice expressing a luciferase gene under the control of a bovine IL-8 promoter. Results: The amount of proteases, pyocyanin and pyoverdine secreted by P. aeruginosa strains was reduced after growth in the presence of a sub-inhibitory dose of clarithromycin. Intratracheal challenge with culture supernatant containing bacteria-released products induced a strong IL-8-mediated response in mouse lungs while lack of virulence factors corresponded to a reduction in bioluminescence emission. Particularly, sole inactivation of proteases by inhibitors Ilomastat and Marimastat also resulted in decreased lung inflammation. Conclusions: Our data support the assumption that virulence factors are involved in P. aeruginosa pro-inflammatory action in CF lungs; particularly, proteases seem to play an important role. Inhibition of virulence factors production and activity resulted in decreased lung inflammation; thus, clarithromycin and protease inhibitors potentially represent additional therapeutic therapies for P. aeruginosa-infected patients.
Additional file 2: of Insulin-like growth factor receptor and sphingosine kinase are prognostic and therapeutic targets in breast cancer
Creators: name: Ochnik, Aleksandra
name: Baxter, Robert
Publisher: name: figshare
Year: 2017
Subjects: subject: Space Science
subject: Cell Biology
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Immunohistochemistry and manual scoring analysis of Australian Breast Cancer Tissue Bank patient samples. Refer to Fig. 1 for experimental details. (DOCX 332Â kb)
Association between sleep duration and high blood pressure in adolescents: a systematic review and meta-analysis
Creators: name: Jiang, Wen
name: Hu, Chengyang
name: Li, Fengli
name: Hua, Xiaoguo
name: Zhang, Xiujun
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Mental Health

description: Context: Sleep has been assessed as a risk factor for health consequences. Among adults, excessively longer and shorter sleep durations are associated with high blood pressure (BP), but knowledge of the association between sleep duration and high BP among adolescents is limited. Objectives: To estimate the associations between sleep duration and high BP in adolescents. Methods: PubMed, Web of Science, and Cochrane databases were searched for eligible publications up until 20 November 2017. This study reviewed the reference lists from retrieved articles to search for relevant studies. Pooled odds ratios (ORs) were calculated using a random-effects meta-analysis. Sub-group and sensitivity analyses were conducted to identify heterogeneity. Publication bias was evaluated using Egger’s test. Results: Seven studies involving 21,150 participants were included, with ages ranging from 10–18 years. For primary analysis, compared with the reference sleep duration, the pooled OR for high BP was 1.51 (95% confidence interval [CI] = 1.04–2.19) for the short sleep duration overall. For long sleep duration, the pooled OR was 1.04 (95% CI = 0.78–1.38). Further sub-group analysis showed that short sleep duration had a higher risk of incident high BP in males (OR = 1.55, 95% CI = 1.24–1.93) than in females (OR = 1.23, 95% CI = 0.47–3.22). Conclusions: Among adolescents, and particularly male adolescents, short sleep duration may be a risk factor for high BP. More attention should be given to this lifestyle factor.
Severe population collapses and species extinctions in multi-host epidemic dynamics
Creators: name: Maslov, Sergei
name: Sneppen, Kim
Publisher: name: arXiv
Year: 2017
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: FOS: Biological sciences

description: Most infectious diseases including more than half of known human pathogens are not restricted to just one host, yet much of the mathematical modeling of infections has been limited to a single species. We investigate consequences of a single epidemic propagating in multiple species and compare and contrast it with the endemic steady state of the disease. We use the two-species Susceptible-Infected-Recovered (SIR) model to calculate the severity of post-epidemic collapses in populations of two host species as a function of their initial population sizes, the times individuals remain infectious, and the matrix of infection rates. We derive the criteria for a very large, extinction-level, population collapse in one or both of the species. The main conclusion of our study is that a single epidemic could drive a species with high mortality rate to local or even global extinction provided that it is co-infected with an abundant species. Such collapse-driven extinctions depend on factors different than those in the endemic steady state of the disease.
Inhibition of Pseudomonas aeruginosa secreted virulence factors reduces lung inflammation in CF mice
Creators: name: Sandri, Angela
name: Ortombina, Alessia
name: Boschi, Federico
name: Cremonini, Eleonora
name: Boaretti, Marzia
name: Sorio, Claudio
name: Melotti, Paola
name: Bergamini, Gabriella
name: Lleo, Maria M
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Background: Cystic fibrosis (CF) lung infection is a complex condition where opportunistic pathogens and defective immune system cooperate in developing a constant cycle of infection and inflammation. The major pathogen, Pseudomonas aeruginosa, secretes a multitude of virulence factors involved in host immune response and lung tissue damage. In this study, we examined the possible anti-inflammatory effects of molecules inhibiting P. aeruginosa virulence factors. Methods: Pyocyanin, pyoverdine and proteases were measured in bacterial culture supernatant from different P. aeruginosa strains. Inhibition of virulence factors by sub-inhibitory concentrations of clarithromycin and by protease inhibitors was evaluated. Lung inflammatory response was monitored by in vivo bioluminescence imaging in wild-type and CFTR-knockout mice expressing a luciferase gene under the control of a bovine IL-8 promoter. Results: The amount of proteases, pyocyanin and pyoverdine secreted by P. aeruginosa strains was reduced after growth in the presence of a sub-inhibitory dose of clarithromycin. Intratracheal challenge with culture supernatant containing bacteria-released products induced a strong IL-8-mediated response in mouse lungs while lack of virulence factors corresponded to a reduction in bioluminescence emission. Particularly, sole inactivation of proteases by inhibitors Ilomastat and Marimastat also resulted in decreased lung inflammation. Conclusions: Our data support the assumption that virulence factors are involved in P. aeruginosa pro-inflammatory action in CF lungs; particularly, proteases seem to play an important role. Inhibition of virulence factors production and activity resulted in decreased lung inflammation; thus, clarithromycin and protease inhibitors potentially represent additional therapeutic therapies for P. aeruginosa-infected patients.
title: 02_1576
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
title: ADCO, Cartulaire de Cîteaux pour les possessions de Tontenant (c. 1504), Cart. 184 (11 H 987), 105 folios, f. 0147
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2015
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire de Cîteaux pour les possessions de Tontenant (c. 1504), Archives départementales de la Côte-d'Or, Cart. 184 (11 H 987), 105 folios, f. 0147, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour les possessions de Tontenant (c. 1504), Archives départementales de la Côte-d'Or, Cart. 184 (11 H 987), 105 folios, f. 0147, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: http://www.wikidata.org/entity/Q843261
Recruiting Software Engineers on Prolific
Creators: name: Russo, Daniel
Publisher: name: arXiv
Year: 2022
Subjects: subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: Recruiting participants for software engineering research has been a primary concern of the human factors community. This is particularly true for quantitative investigations that require a minimum sample size not to be statistically underpowered. Traditional data collection techniques, such as mailing lists, are highly doubtful due to self-selection biases. The introduction of crowdsourcing platforms allows researchers to select informants with the exact requirements foreseen by the study design, gather data in a concise time frame, compensate their work with fair hourly pay, and most importantly, have a high degree of control over the entire data collection process. This experience report discusses our experience conducting sample studies using Prolific, an academic crowdsourcing platform. Topics discussed are the type of studies, selection processes, and power computation.
Recombinant chimpanzee adenovirus AdC7 expressing dimeric tandem-repeat spike protein RBD protects mice against COVID-19
Creators: name: Xu, Kun
name: An, Yaling
name: Li, Qunlong
name: Huang, Weijin
name: Han, Yuxuan
name: Zheng, Tianyi
name: Fang, Fang
name: Liu, Hui
name: Liu, Chuanyu
name: Gao, Ping
name: Xu, Senyu
name: Liu, Xueyuan
name: Zhang, Rong
name: Zhao, Xin
name: Liu, William J.
name: Bi, Yuhai
name: Wang, Youchun
name: Zhou, Dongming
name: Wang, Qinghan
name: Hou, Wenli
name: Xia, Qianfeng
name: Gao, George F.
name: Dai, Lianpan
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: A safe and effective vaccine is urgently needed to control the unprecedented COVID-19 pandemic. Four adenovirus-vectored vaccines expressing spike (S) protein have been approved for use. Here, we generated several recombinant chimpanzee adenovirus (AdC7) vaccines expressing S, receptor-binding domain (RBD), or tandem-repeat dimeric RBD (RBD-tr2). We found vaccination via either intramuscular or intranasal route was highly immunogenic in mice to elicit both humoral and cellular immune responses. AdC7-RBD-tr2 showed higher antibody responses compared to either AdC7-S or AdC7-RBD. Intranasal administration of AdC7-RBD-tr2 additionally induced mucosal immunity with neutralizing activity in bronchoalveolar lavage fluid. Either single-dose or two-dose mucosal administration of AdC7-RBD-tr2 protected mice against SARS-CoV-2 challenge, with undetectable subgenomic RNA in lung and relieved lung injury. AdC7-RBD-tr2-elicted sera preserved the neutralizing activity against the circulating variants, especially the Delta variant. These results support AdC7-RBD-tr2 as a promising COVID-19 vaccine candidate.
Ordination by media?: analysis of news texts constructing the debate over women's ordination to the priesthood in the Anglican Church of Australia in four daily newspapers, 1987-1992
Creators: name: Bartholomeusz, Judith Rose
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Over 200 news texts that construct the debate over the ordination of women to the priesthood in the Anglican Church of Australia are analysed. Attention is drawn to modal and modal-like constructions of credibility for news actors in verbal text and in photographs. Focus is placed also on the construction of affective mental processes and emotion, producing social affinity between reader-viewer and represented participant. This approach follows Kress and van Leeuwen, who combine social semiotics and functional linguistics, and propose a 'grammar' of visual images. -- Attention is paid also to the contributing discourses to the ordination debate, both theological and feminist. It is demonstrated that the press disguised a complex discursive reality with many competing meanings between theological traditions and between feminisms. It is argued that the press have constructed the debate in 'the social'. Within 'the social' three 'discourses' are recognised: democratic-legislative; progress (reflecting Enlightenment thought); and unity, the latter two being measured against the former. It is argued that press evaluation has produced a 'mediated theological orthodoxy' in 'the social'. -- It is concluded that credibility evaluations must be viewed in the light of the structuring characteristics of news discourse reflecting the market orientation of the industry. 'Ordination by media' points to an implicit ideological predisposition, but not a conscious press commitment to women's ordination.
Additional file 1: of Customer satisfaction of Vietnam Airline domestic service quality
Creators: name: Khanh, Giao Ha Nam
Publisher: name: figshare
Year: 2017
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Science Policy

description: Variable measurement. (DOCX 12Â kb)
title: 02_0542
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Impact of contusion injury on intramuscular emm1 group a streptococcus infection and lymphatic spread
Creators: name: Lamb, L. E.
name: Siggins, M. K.
name: Scudamore, C.
name: Macdonald, W.
name: Turner, C. E.
name: Lynskey, N. N.
name: Tan, L. K. K.
name: Sriskandan, S.
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Invasive group A Streptococcus (iGAS) is frequently associated with emm1 isolates, with an attendant mortality of around 20%. Cases occasionally arise in previously healthy individuals with a history of upper respiratory tract infection, soft tissue contusion, and no obvious portal of entry. Using a new murine model of contusion, we determined the impact of contusion on iGAS bacterial burden and phenotype. Calibrated mild blunt contusion did not provide a focus for initiation or seeding of GAS that was detectable following systemic GAS bacteremia, but instead enhanced GAS migration to the local draining lymph node following GAS inoculation at the same time and site of contusion. Increased migration to lymph node was associated with emergence of mucoid bacteria, although was not specific to mucoid bacteria. In one study, mucoid colonies demonstrated a significant increase in capsular hyaluronan that was not linked to a covRS or rocA mutation, but to a deletion in the promoter of the capsule synthesis locus, hasABC, resulting in a strain with increased fitness for lymph node migration. In summary, in the mild contusion model used, we could not detect seeding of muscle by GAS. Contusion promoted bacterial transit to the local lymph node. The consequences of contusion-associated bacterial lymphatic migration may vary depending on the pathogen and virulence traits selected.
Global regularity for the fractional Euler alignment system
Creators: name: Do, Tam
name: Kiselev, Alexander
name: Ryzhik, Lenya
name: Tan, Changhui
Publisher: name: arXiv
Year: 2017
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: We study a pressureless Euler system with a nonlinear density-dependent alignment term, originating in the Cucker-Smale swarming models. The alignment term is dissipative in the sense that it tends to equilibrate the velocities. Its density dependence is natural: the alignment rate increases in the areas of high density due to species discomfort. The diffusive term has the order of a fractional Laplacian $(-\partial_{xx})^{α/2}$, $α\in (0, 1)$. The corresponding Burgers equation with a linear dissipation of this type develops shocks in a finite time. We show that the alignment nonlinearity enhances the dissipation, and the solutions are globally regular for all $α\in (0, 1)$. To the best of our knowledge, this is the first example of such regularization due to the non-local nonlinear modulation of dissipation.
description: 34 pages
Interactive mental map of aquatic functional traits
Creators: name: Séverine, Martini
name: Larras Floriane
name: Boyé Aurélien
name: Faure Emile
name: Aberle Nicole
name: Archambault Philippe
name: Baccouillard Lise
name: Beisner Beatrix E
name: Bittner Lucie
name: Castella Emmanuel
name: Danger Michael
name: Olivier, Gauthier
name: Karp-Boss Lee
name: Lombard Fabien
name: Maps Frédéric
name: Stemmann Lars
name: Thiébault Eric
name: Usseglio-Polatera Philippe
name: Vogt Meike
name: Laviale Martin
name: Ayata Sakina-Dorothée
Publisher: name: Zenodo
Year: 2020
Subjects: functional trait
marine
freshwater
trait-based approaches
imaging
omics
modeling
aquatic ecology
limnology
oceanography

description: Interactive mental map of aquatic functional traits described in the unified topology. Hover your mouse over a node to highlight its connections. A simple click on a node will open a bibliography search about this trait in aquatic ecology studies. A maintained click on any node will allow you to move it around. Scroll to zoom in or out.
Additional file 1: of Classification schemes for knowledge translation interventions: a practical resource for researchers
Creators: name: Slaughter, Susan
name: Zimmermann, Gabrielle
name: Nuspl, Megan
name: Hanson, Heather
name: Albrecht, Lauren
name: Rosmin Esmail
name: Khara Sauro
name: Newton, Amanda
name: Maoliosa Donald
name: Dyson, Michele
name: Thomson, Denise
name: Hartling, Lisa
Publisher: name: figshare
Year: 2017
Subjects: subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Marine Biology
subject: Science Policy

description: Adaptations of the AGREE II tool. (DOCX 21Â kb)
Finite temperature properties of strongly correlated systems via variational Monte Carlo
Creators: name: Claes, Jahan
name: Clark, Bryan K.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Variational methods are a common approach for computing properties of ground states but have not yet found analogous success in finite temperature calculations. In this work we develop a new variational finite temperature algorithm (VAFT) which combines ideas from minimally entangled typical thermal states (METTS), variational Monte Carlo (VMC) optimization and path integral Monte Carlo (PIMC). This allows us to define an implicit variational density matrix to estimate finite temperature properties in two and three dimensions. We benchmark the algorithm on the bipartite Heisenberg model and compare to exact results.
description: 9 pages
Examining passive riparian revegetation in degraded rivers: livestock exclusion and environmental flows
Creators: name: Stone, Luke James
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Passive riparian revegetation techniques are becoming increasingly important tools in river rehabilitation. However the utility of the sediment seed bank as a passive riparian regeneration option is poorly understood. A livestock excluded site has been monitored over a three year period and compared to a continuously grazed site to test the regeneration potential of the seed bank. Livestock exclusion was successful in increasing erosion resistance (roughness) and the regeneration of native species but not successful in restoring communities or regenerating substantial numbers of woody species. The utility of the seed bank does not extend to the restoration of full communities and requires direct plantings to provide a more developed assemblage. A seedling emergence experiment has compared the effects of simulated flood durations on the seedling emergence of desirable riparian species. The inundation of bench units using environmental flows would not significantly increase or decrease recruitment of desirable species from the seed bank. Significant differences in seedling emergence and timing under different inundation periods were found to vary among species. These studies provide greater understanding of how passive revegetation utilising riparian seed banks can best achieve river rehabilitation goals and how revegetation objectives should be framed when utilising riparian seed banks.