title: ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÐ»ÐµÐºÑÑÐ¾ÑÐ¾ÑÐµÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¾ÑÐ°Ð¶Ð´ÐµÐ½Ð¸Ñ TiO2 Ð´Ð»Ñ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð² Ð¿Ð¾Ð²ÐµÑÑ Ð½Ð¾ÑÑÐ½Ð¾-Ð°ÐºÑÐ¸Ð²Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð¹ Ð»Ð°Ð·ÐµÑÐ½Ð¾Ð¹ Ð´ÐµÑÐ¾ÑÐ±ÑÐ¸Ð¸/Ð¸Ð¾Ð½Ð¸Ð·Ð°ÑÐ¸Ð¸
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Research of electrophoretic deposition TiO2 for application in surface-assisted laser desorption/ionization
Creators: name: ÐÐ°Ð±Ð´ÑÐ°ÑÐ¼Ð°Ð½Ð¾Ð²Ð°, ÐÑÐ»ÑÐ½Ð°ÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: Ð¼Ð°ÑÑ-ÑÐ¿ÐµÐºÑÑÐ¾Ð¼ÐµÑÑÐ¸Ñ
Ð¿Ð¾Ð²ÐµÑÑ Ð½Ð¾ÑÑÐ½Ð¾-Ð°ÐºÑÐ¸Ð²Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð°Ñ Ð»Ð°Ð·ÐµÑÐ½Ð°Ñ Ð´ÐµÑÐ¾ÑÐ±ÑÐ¸Ñ/Ð¸Ð¾Ð½Ð¸Ð·Ð°ÑÐ¸Ñ
ÑÐ»ÐµÐºÑÑÐ¾ÑÐ¾ÑÐµÑÐ¸ÑÐµÑÐºÐ¾Ðµ Ð¾ÑÐ°Ð¶Ð´ÐµÐ½Ð¸Ðµ
Ð´Ð¸Ð¾ÐºÑÐ¸Ð´ ÑÐ¸ÑÐ°Ð½Ð°
Ð°Ð¼Ð¸Ð¾Ð´Ð°ÑÐ¾Ð½
mass spectrometry
surface-assisted laser desorption/ ionization
electrophoretic deposition
titanium dioxide
amiodarone

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ ÑÐ»ÐµÐºÑÑÐ¾ÑÐ¾ÑÐµÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¾ÑÐ°Ð¶Ð´ÐµÐ½Ð¸Ñ TiO2 Ð´Ð»Ñ ÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¾Ð´Ð½Ð¾ÑÐ¾Ð´Ð½ÑÑ Ð¿Ð¾Ð²ÐµÑÑÐ½Ð¾ÑÑÐµÐ¹ Ð¸ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ Ð¿Ð¾Ð²ÐµÑÑÐ½Ð¾ÑÑÐµÐ¹ Ð´Ð»Ñ Ð¼Ð°ÑÑ-ÑÐ¿ÐµÐºÑÑÐ¾Ð¼ÐµÑÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° Ð»ÐµÐºÐ°ÑÑÑÐ²ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ° Ð°Ð¼Ð¸Ð¾Ð´Ð°ÑÐ¾Ð½ Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ Ð¿Ð¾Ð²ÐµÑÑÐ½Ð¾ÑÑÐ½Ð¾-Ð°ÐºÑÐ¸Ð²Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð¹ Ð»Ð°Ð·ÐµÑÐ½Ð¾Ð¹ Ð´ÐµÑÐ¾ÑÐ±ÑÐ¸Ð¸/Ð¸Ð¾Ð½Ð¸Ð·Ð°ÑÐ¸Ð¸ (ÐÐ¡ ÐÐÐÐÐ). ÐÐ°Ð´Ð°ÑÐ¸, ÐºÐ¾ÑÐ¾ÑÑÐµ ÑÐµÑÐ°Ð»Ð¸ÑÑ Ð² ÑÐ¾Ð´Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ: 1. ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÐ»ÐµÐºÑÑÐ¾ÑÐ¾ÑÐµÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¾ÑÐ°Ð¶Ð´ÐµÐ½Ð¸Ñ TiO2 Ð½Ð° Ð½ÐµÑÐ¶Ð°Ð²ÐµÑÑÑÑ ÑÑÐ°Ð»Ñ. 2. ÐÑÐµÐ½ÐºÐ° Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½Ð¾ÑÑÐ¸ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð¼Ð¾Ð´Ð¸ÑÐ¸ÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð³Ð¾ Ð¿Ð¾Ð»Ð¸Ð´Ð¸Ð¼ÐµÑÐ¸Ð»ÑÐ¸Ð»Ð¾ÐºÑÐ°Ð½Ð¾Ð¼ TiO2 Ð´Ð»Ñ ÐÐ¡ ÐÐÐÐÐ. 3. ÐÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ðµ Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÐ¾Ð² ÑÐ»ÐµÐºÑÑÐ¾ÑÐ¾ÑÐµÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¾ÑÐ°Ð¶Ð´ÐµÐ½Ð¸Ñ TiO2, Ð¾Ð±ÐµÑÐ¿ÐµÑÐ¸Ð²Ð°ÑÑÐ¸Ñ Ð½Ð°Ð¸Ð±Ð¾Ð»ÐµÐµ ÑÑÑÐµÐºÑÐ¸Ð²Ð½ÑÑ Ð¸Ð¾Ð½Ð¸Ð·Ð°ÑÐ¸Ñ Ð»ÐµÐºÐ°ÑÑÑÐ²ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ° Ð°Ð¼Ð¸Ð¾Ð´Ð°ÑÐ¾Ð½. Ð Ð°Ð±Ð¾ÑÐ° Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð° Ð½Ð° Ð±Ð°Ð·Ðµ Ð¤ÐÐ£Ð Â«ÐÐÐ ÐÐÐ­Ð§Â» Ð¤ÐÐÐ Ð Ð¾ÑÑÐ¸Ð¸, Ð³Ð´Ðµ ÑÐ¾Ð±Ð¸ÑÐ°Ð»Ð¸ÑÑ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÐµ Ð´Ð°Ð½Ð½ÑÐµ. Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ Ð±ÑÐ»Ð¸ Ð¿Ð¾Ð»ÑÑÐµÐ½Ñ Ð¸ Ð¾ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸Ð·Ð¾Ð²Ð°Ð½Ñ ÑÐ»ÐµÐºÑÑÐ¾ÑÐ¾ÑÐµÑÐ¸ÑÐµÑÐºÐ¸ Ð¾ÑÐ°Ð¶Ð´ÐµÐ½Ð½ÑÐµ Ð¿Ð¾Ð²ÐµÑÑÐ½Ð¾ÑÑÐ¸ TiO2. ÐÑÐ»Ð¾ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð½Ð¾, ÑÑÐ¾ Ð¼Ð¾Ð´Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ñ ÑÐ»ÐµÐºÑÑÐ¾ÑÐ¾ÑÐµÑÐ¸ÑÐµÑÐºÐ¸ Ð¾ÑÐ°Ð¶Ð´ÐµÐ½Ð½ÑÑ Ð¿Ð¾Ð²ÐµÑÑÐ½Ð¾ÑÑÐµÐ¹ TiO2 Ð¿Ð¾Ð»Ð¸Ð´Ð¸Ð¼ÐµÑÐ¸Ð»ÑÐ¸Ð»Ð¾ÐºÑÐ°Ð½Ð¾Ð¼ Ð¿Ð¾Ð´ Ð²Ð¾Ð·Ð´ÐµÐ¹ÑÑÐ²Ð¸ÐµÐ¼ Ð£Ð¤ Ð¸Ð·Ð»ÑÑÐµÐ½Ð¸Ñ Ð¿Ð¾Ð·Ð²Ð¾Ð»ÑÐµÑ Ð¿Ð¾Ð»ÑÑÐ°ÑÑ ÑÑÐ¿ÐµÑÐ³Ð¸Ð´ÑÐ¾ÑÐ¾Ð±Ð½ÑÐµ Ð¿Ð¾Ð²ÐµÑÑÐ½Ð¾ÑÑÐ¸, Ð¿Ð¾Ð´ÑÐ¾Ð´ÑÑÐ¸Ðµ Ð´Ð»Ñ ÐÐÐÐÐ/ÐÐ¡ Ð°Ð½Ð°Ð»Ð¸Ð·Ð°. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ ÑÐ»ÐµÐºÑÑÐ¾ÑÐ¾ÑÐµÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¾ÑÐ°Ð¶Ð´ÐµÐ½Ð¸Ñ TiO2 Ð¿Ð¾Ð²ÐµÑÑÐ½Ð¾ÑÑÐ¸ Ð¸Ð´ÐµÐ°Ð»ÑÐ½Ð¾ Ð¿Ð¾Ð´ÑÐ¾Ð´ÑÑ Ð´Ð»Ñ ÐÐ¡ ÐÐÐÐÐ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° Ð½Ð¸Ð·ÐºÐ¾Ð¼Ð¾Ð»ÐµÐºÑÐ»ÑÑÐ½ÑÑ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ð¹. ÐÐ°Ð½Ð½ÑÐµ Ð¿Ð¾Ð²ÐµÑÑÐ½Ð¾ÑÑÐ¸ Ð´ÐµÐ¼Ð¾Ð½ÑÑÑÐ¸ÑÑÑÑ Ð»ÑÑÑÑÑ Ð²Ð¾ÑÐ¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´Ð¸Ð¼Ð¾ÑÑÑ Ð´ÐµÑÐ¾ÑÐ±ÑÐ¸Ð¸ Ð°Ð½Ð°Ð»Ð¸ÑÐ°, ÑÐµÐ¼ Ð¿Ð¾Ð²ÐµÑÑÐ½Ð¾ÑÑÐ¸, Ð¿ÑÐ¸Ð³Ð¾ÑÐ¾Ð²Ð»ÐµÐ½Ð½ÑÐµ Ñ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸ÐµÐ¼ ÑÑÐ°Ð´Ð¸ÑÐ¸Ð¾Ð½Ð½ÑÑ Ð¿Ð¾Ð´ÑÐ¾Ð´Ð¾Ð². ÐÐ¿ÐµÑÐ²ÑÐµ Ð¿ÑÐ¾Ð´ÐµÐ¼Ð¾Ð½ÑÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð° Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½Ð¾ÑÑÑ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð¿Ð¾Ð²ÐµÑÑÐ½Ð¾ÑÑÐµÐ¹ ÑÐ»ÐµÐºÑÑÐ¾ÑÐ¾ÑÐµÑÐ¸ÑÐµÑÐºÐ¸ Ð¾ÑÐ°Ð¶Ð´ÐµÐ½Ð½Ð¾Ð³Ð¾ TiO2 Ð´Ð»Ñ ÐÐ¡ ÐÐÐÐÐ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° Ð»ÐµÐºÐ°ÑÑÑÐ²ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ° Ð°Ð¼Ð¸Ð¾Ð´Ð°ÑÐ¾Ð½.
description: This work is devoted to the application of electrophoretic deposition TiO2 for the formation of homogeneous surfaces and the application of the obtained surfaces for mass spectrometric analysis of the drug amiodarone using surface-assisted laser desorption/ionization (MS SALDI). The research set the following goals: 1. Research of electrophoretic deposition TiO2 on stainless steel. 2. Assessment of the possibility of application modified TiO2 with polydimethylsiloxane for SALDI MS. 3. Determination of electrophoretic deposition TiO2 parameters providing the most effective ionization of the drug amiodarone. The work was fulfilled at âRIHOPHEâ FMBA, where experimental data were collected. The study resulted electrophoretically deposited TiO2 surfaces were obtained and characterized. It was shown that modification of the obtained surfaces with polydimethylsiloxane under the influence of UV radiation makes it possible to obtain superhydrophobic surfaces suitable for MS SALDI MS analysis. Ð¢Ð½Ðµ surfaces obtained by electrophoretic deposition TiO2 are ideally suited for SALDI MS analysis of low molecular weight compounds. These surfaces demonstrate better reproducibility of analyte desorption than surfaces prepared with application traditional approaches. The possibility of using electrophoretically deposited TiO2 surfaces for the MS SALDI analysis of the drug amiodarone was demonstrated for the first time.