cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
KdV waves in atomic chains with nonlocal interactions
Creators: name: Herrmann, Michael
name: Mikikits-Leitner, Alice
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: Dynamical Systems (math.DS)
subject: Pattern Formation and Solitons (nlin.PS)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We consider atomic chains with nonlocal particle interactions and prove the existence of near-sonic solitary waves. Both our result and the general proof strategy are reminiscent of the seminal paper by Friesecke and Pego on the KdV limit of chains with nearest neighbor interactions but differ in the following two aspects: First, we allow for a wider class of atomic systems and must hence replace the distance profile by the velocity profile. Second, in the asymptotic analysis we avoid a detailed Fourier pole characterization of the nonlocal integral operators and employ the contraction mapping principle to solve the final fixed point problem.
description: revised version with corrected typos and minor improvements in the discussion of technical details; 20 pages, 4 figures
D4.10 Dissemination report IV
Creators: name: Szemerédi Csányiné, Eszter
name: Kupi, Marcell
name: Hardi, Tamás
Publisher: name: Zenodo
Year: 2022
Subjects: SPOT
deliverable
report
dissemination

description: The objective of deliverable 4.10 is to describe the dissemination activities of the project as a whole for the period of 1 January – 15 July 2022, as well as report on the activities carried out by each partner. This paper continues and complements the second and third issues of the Spot Dissemination Report, which are available on the project’s website in its open area (http://www.spotprojecth2020.eu/reportsandoutcomes).
Spin texture of generic helical edge states
Creators: name: Rod, Alexia
name: Schmidt, Thomas L.
name: Rachel, Stephan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study the spin texture of a generic helical liquid, the edge modes of a two-dimensional topological insulator with broken axial spin-symmetry. By considering honeycomb and square lattice realizations of topological insulators, we show that in all cases the generic behavior of a momentum-dependent rotation of the spin quantization axis is realized. Here we establish this mechanism also for disk geometries with continuous rotational symmetry. Finally, we demonstrate that the rotation of spin-quantization axis remains intact for arbitrary geometries, i.e. in the absence of any continuous symmetry. We also calculate the dependence of this rotation on the model and material parameters. Finally we propose a spectroscopy measurement which should directly reveal the rotation of the spin-quantization axis of the helical edge states.
description: 16 pages, 17 figures
Maps: Model-based analysis of long-range chromatin interactions from PLAC-seq and HiChIP experiments
Creators: name: Fang, R.
name: Juric, I.
name: Abnousi, A.
name: Ren, B.
name: Hu, M.
name: Yu, M.
name: Zhao, Y.
name: Yu, M.
name: Zhang, Y.
name: Zhang, Y.
name: Li, Y.
name: Hu, M.
name: Ren, B.
name: Li, Y.
name: Yang, Y.
name: Raviram, R.
name: Yang, Y.
name: Zhao, Y.
name: Qiu, Y.
name: Abnousi, A.
name: Qiu, Y.
name: Juric, I.
name: Raviram, R.
name: Fang, R.
Publisher: name: Public Library of Science
Year: 2019

description: Hi-C and chromatin immunoprecipitation (ChIP) have been combined to identify long-range chromatin interactions genome-wide at reduced cost and enhanced resolution, but extracting information from the resulting datasets has been challenging. Here we describe a computational method, MAPS, Model-based Analysis of PLAC-seq and HiChIP, to process the data from such experiments and identify long-range chromatin interactions. MAPS adopts a zero-truncated Poisson regression framework to explicitly remove systematic biases in the PLAC-seq and HiChIP datasets, and then uses the normalized chromatin contact frequencies to identify significant chromatin interactions anchored at genomic regions bound by the protein of interest. MAPS shows superior performance over existing software tools in the analysis of chromatin interactions from multiple PLAC-seq and HiChIP datasets centered on different transcriptional factors and histone marks.
Additional file 1 of Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer’s-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative microglia
Creators: name: Shi, Haoshen
name: Yin, Zhuoran
name: Koronyo, Yosef
name: Fuchs, Dieu-Trang
name: Sheyn, Julia
name: Davis, Miyah R.
name: Wilson, Jered W.
name: Margeta, Milica A.
name: Pitts, Kristen M.
name: Herron, Shawn
name: Ikezu, Seiko
name: Ikezu, Tsuneya
name: Graham, Stuart L.
name: Gupta, Vivek K.
name: Black, Keith L.
name: Mirzaei, Mehdi
name: Butovsky, Oleg
name: Koronyo-Hamaoui, Maya
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file1: Supplementary Figures 1-9 and Tables 1-8.
Anomalous dynamical scaling from nematic and U(1)-gauge field fluctuations in two dimensional metals
Creators: name: Holder, Tobias
name: Metzner, Walter
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We analyze the scaling theory of two-dimensional metallic electron systems in the presence of critical bosonic fluctuations with small wave vectors, which are either due to a U(1) gauge field, or generated by an Ising nematic quantum critical point. The one-loop dynamical exponent z=3 of these critical systems was shown previously to be robust up to three-loop order. We show that the cancellations preventing anomalous contributions to z at three-loop order have special reasons, such that anomalous dynamical scaling emerges at four-loop order.
description: 5 pages, 3 figures; supplementary material (4 pages, 3 figures). Conclusions and supplements updated in v2
title: Jeter une pierre
title: Throw a stone
Creators: name: Li, Juan
Publisher: name: Pangloss
Year: 2022
Subjects: subject: Linguistique
subject: Tai Lue

description: This is a staged communicative event: the consultant is asked to describe in her own words what she observes regarding three Story Build picture cards she has chosen: Character 3_Action 1_Action 9 (Katie Sardinha, www.story-builder.ca).
A hidden Markov random field-based Bayesian method for the detection of long-range chromosomal interactions in Hi-C data
Creators: name: Chen, M.
name: Jin, F.
name: Sullivan, P.F.
name: Zhang, G.
name: Xu, Z.
name: Qin, Z.
name: Li, Y.
name: Hu, M.
name: Furey, T.S.
Publisher: name: Oxford University Press
Year: 2016

description: Motivation: Advances in chromosome conformation capture and next-generation sequencing technologies are enabling genome-wide investigation of dynamic chromatin interactions. For example, Hi-C experiments generate genome-wide contact frequencies between pairs of loci by sequencing DNA segments ligated from loci in close spatial proximity. One essential task in such studies is peak calling, that is, detecting non-random interactions between loci from the two-dimensional contact frequency matrix. Successful fulfillment of this task has many important implications including identifying long-range interactions that assist interpreting a sizable fraction of the results from genome-wide association studies. The task - distinguishing biologically meaningful chromatin interactions from massive numbers of random interactions - poses great challenges both statistically and computationally. Model-based methods to address this challenge are still lacking. In particular, no statistical model exists that takes the underlying dependency structure into consideration. Results: In this paper, we propose a hidden Markov random field (HMRF) based Bayesian method to rigorously model interaction probabilities in the two-dimensional space based on the contact frequency matrix. By borrowing information from neighboring loci pairs, our method demonstrates superior reproducibility and statistical power in both simulation studies and real data analysis.
Single Nucleotide Polymorphism (SNP) Detection and Genotype Calling from Massively Parallel Sequencing (MPS) Data
Creators: name: Zhou, Y.-H.
name: Li, Y.
name: Chen, W.
name: Liu, E.Y.
Publisher: name: Springer Science and Business Media, LLC
Year: 2013

description: Massively parallel sequencing (MPS), since its debut in 2005, has transformed the field of genomic studies. These new sequencing technologies have resulted in the successful identification of causal variants for several rare Mendelian disorders. They have also begun to deliver on their promise to explain some of the missing heritability from genome-wide association studies (GWAS) of complex traits. We anticipate a rapidly growing number of MPS-based studies for a diverse range of applications in the near future. One crucial and nearly inevitable step is to detect SNPs and call genotypes at the detected polymorphic sites from the sequencing data. Here, we review statistical methods that have been proposed in the past five years for this purpose. In addition, we discuss emerging issues and future directions related to SNP detection and genotype calling from MPS data.
title: Unzugängliche Welten für das erfahrungsbasierte Lernen erschließen. Immersive Virtuelle Realität im naturwissenschaftlichen Sachunterricht
Creators: name: Dubach, Josua
name: Schelleis, Natalie
name: Bölsterli, Katrin
name: Cacchione, Trix
name: Martarelli, Corinna
name: Probst, Matthias
name: Tempelmann, Sebastian
Publisher: name: Julius Klinkhardt
Year: 2022

description: Die Autor*innen befassen sich mit der Erschließung „Unzugängliche[r] Welten für das erfahrungsbasierte Lernen“, indem sie Potenziale der Integration Immersiver Virtueller Realität (IVR) in den naturwissenschaftlichen Sachunterricht erläutern. Designprinzipien und Beispiele für die Nutzung von Immersiver Virtueller Realität im naturwissenschaftlichen Sachunterricht werden anhand einer exemplarischen Sachunterrichtseinheit zum so genannten kleinen Wasserkreislauf aufgezeigt und diskutiert. (DIPF/Orig.)
Updated NNLO QCD predictions for the weak radiative B-meson decays
Creators: name: Misiak, M.
name: Asatrian, H. M.
name: Boughezal, R.
name: Czakon, M.
name: Ewerth, T.
name: Ferroglia, A.
name: Fiedler, P.
name: Gambino, P.
name: Greub, C.
name: Haisch, U.
name: Huber, T.
name: Kaminski, M.
name: Ossola, G.
name: Poradzinski, M.
name: Rehman, A.
name: Schutzmeier, T.
name: Steinhauser, M.
name: Virto, J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Weak radiative decays of the B mesons belong to the most important flavor changing processes that provide constraints on physics at the TeV scale. In the derivation of such constraints, accurate standard model predictions for the inclusive branching ratios play a crucial role. In the current Letter we present an update of these predictions, incorporating all our results for the O(alpha_s^2) and lower-order perturbative corrections that have been calculated after 2006. New estimates of nonperturbative effects are taken into account, too. For the CP- and isospin-averaged branching ratios, we find B_{s gamma} = (3.36 +_ 0.23) * 10^-4 and B_{d gamma} = 1.73^{+0.12}_{-0.22} * 10^-5, for E_gamma > 1.6GeV. Both results remain in agreement with the current experimental averages. Normalizing their sum to the inclusive semileptonic branching ratio, we obtain R_gamma = ( B_{s gamma} + B_{d gamma})/B_{c l nu} = (3.31 +_ 0.22) * 10^-3. A new bound from B_{s gamma} on the charged Higgs boson mass in the two-Higgs-doublet-model II reads M_{H^+} > 480 GeV at 95%C.L.
description: journal version, 5 pages, no figures
Carolina Franceschinis Valvassori (Udine, 19 agosto 1866 – Udine, 20 aprile 1950) / Daniele Vergari, Davide Fiorino
Creators: name: Vergari, Daniele
name: Fiorino, Davide
name: Franceschinis Valvassori, Carolina
Publisher: name: Zenodo
Year: 2022
Subjects: Accademia dei Georgofili
Franceschinis Valvassori, Carolina
Vergari, Daniele
Fiorino, Davide
Biografie
Biography
Donne
Scienziate
Pregiudizi

description: Testo originale della Mostra virtuale: Riconoscere il merito, superare i pregiudizi: scienziate ai Georgofili (1753-1911) Natura: risorsa elettronica. Consistenza: [5] p. Incipit: Carolina Franceschinis Valvassori è la quarta accademica dei Georgofili in ordine cronologico di elezione, che prendiamo in esame. Nota sia per l’impegno prestato al fianco del marito Vincenzo Valvassori che per le sue attività di insegnamento negli Istituti femminili nei primi decenni del XX secolo, la sua figura è intimamente legata alla fondazione ed alla direzione dell’Istituto Agrario Femminile e di Economia Domestica di Firenze...
description: Digitalizzato come parte della Mostra virtuale: Riconoscere il merito, superare i pregiudizi: scienziate ai Georgofili (1753-1911). https://www.georgofili.it/contenuti/riconoscere-il-merito-superare-i-pregiudizi-scienziate-ai-georgofili-1753-1911-mostra-in-rete/11369
title: un petit garçon et son ami
title: A little boy and his friend
Creators: name: Li, Juan
Publisher: name: Pangloss
Year: 2022
Subjects: subject: Linguistique
subject: Tai Lue

description: This is a staged communicative event: the consultant is asked to describe in her own words what she observes regarding three Story Build picture cards she has chosen: Character 20_Action 28_Action 39 (Katie Sardinha, www.story-builder.ca).
Additional file 1 of Performance of model-based vs. permutation tests in the HEALing (Helping to End Addiction Long-termSM) Communities Study, a covariate-constrained cluster randomized trial
Creators: name: Tang, Xiaoyu
name: Heeren, Timothy
name: Westgate, Philip M.
name: Feaster, Daniel J.
name: Fernandez, Soledad A.
name: Vandergrift, Nathan
name: Cheng, Debbie M.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy

description: Additional file 1: Supplementary Table 1. Distribution of number of opioid overdose deaths from 5,000 simulations across 67 communities in the HCS*. Supplementary Table 2. Type I error rate for the Model-Based and Permutation Tests from the unadjusted model for the HEALing Communities Study Design, Overall (4 States) and for the subgroup analysis of Massachusetts. Supplementary Table 3. Power for the Model-Based and Permutation Tests from the unadjusted model to Detect Various Differences Between Groups in Number of Opioid Overdose Deaths. Supplementary Table 4. Type I error rate for the Model-Based and Permutation Tests from the fully adjusted model removing Urban/Rural as the covariate for the HEALing Communities Study Design, Overall (4 States) and for the subgroup analysis of Massachusetts. Supplementary Table 5. Power for the Model-Based and Permutation Tests from the fully adjusted model removing Urban/Rural as the covariate to Detect Various Differences Between Groups in Number of Opioid Overdose Deaths. Supplementary Table 6. Type I error rate for the Model-Based and Permutation Tests from the fully adjusted model removing baseline death rates as the covariate for the HEALing Communities Study Design, Overall (4 States) and for the subgroup analysis of Massachusetts. Supplementary Table 7. Power for the Model-Based and Permutation Tests from the fully adjusted model removing baseline death rates as the covariate to Detect Various Differences Between Groups in Number of Opioid Overdose Deaths. Supplementary Table 8. Type I error rate for the Model-Based and Permutation Tests for the HEALing Communities Study Design, Overall (4 States) and for the subgroup analysis of Massachusetts for different random allocations. Supplementary Table 9. Power for the Model-Based and Permutation Tests to Detect Various Differences Between Groups in Number of Opioid Overdose Deaths for different random allocations. Supplementary Text 1.
Three Decades of Customer Value Research: Paradigmatic Roots and Future Research Avenues
Creators: name: Verleye, K.
name: Zauner, A.
name: Hatak, I.
name: Zeithaml, V.A.
name: Koller, M.
Publisher: name: SAGE Publications Inc.
Year: 2020

description: The last three decades have witnessed a resurgence of research on the topic of customer value. In search of a comprehensive integration and analysis of this research—including conceptualization, operationalization, and measurement—we examined the myriad journal publications on the construct. We acknowledge that while some of the literature can be fully integrated, other parts are more difficult because they represent three different paradigms: positivist, interpretive, and social constructionist. We begin by briefly describing these three paradigms. Next, we detail the many studies representing the positivist paradigm, literature capturing customer value from just the customer’s perspective and using deductive logic. We designate the second paradigm as interpretive, in that researchers are interested in understanding the subjective nature of customer value along with its emergence through inductive logic. The third paradigm, the social constructionist, frames customer value as emerging from value co-creation practices in complex ecosystems. Building upon the commonalities and differences among research studies stemming from the positivist, interpretive, and social constructionist paradigms, we propose how researchers can complement one another to move the customer value field forward.
Additional file 2 of The Core Rehabilitation Outcome Set for Single-Sided Deafness (CROSSSD) study: International consensus on outcome measures for trials of interventions for adults with single-sided deafness
Creators: name: Katiri, Roulla
name: Hall, Deborah A.
name: Hoare, Derek J.
name: Fackrell, Kathryn
name: Horobin, Adele
name: Hogan, Nicholas
name: Buggy, Nóra
name: Van de Heyning, Paul H.
name: Firszt, Jill B.
name: Bruce, Iain A.
name: Kitterick, Pádraig T.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 2. e-Delphi Round 1 and Round 2 outcome domain distribution scores
User-informed marketing versus standard description to drive demand for evidence-based therapy: A randomized controlled trial.
Creators: name: Tavares, T.L.
name: Squires, D.D.
name: Zeithaml, V.A.
name: Becker, S.J.
name: Helseth, S.A.
name: Clark, M.A.
name: Spirito, A.
Publisher: name: American Psychological Association
Year: 2020

description: Direct-to-consumer (DTC) marketing represents a vital strategy to disseminate evidence-based therapies (EBTs). This 3-phase research program, informed by the marketing mix, developed and evaluated user-informed DTC materials for parents concerned about adolescent substance use (SU). Phases 1 and 2 consisted of qualitative interviews (n = 29 parents) and a quantitative survey (n = 411), respectively, to elicit parents’ preferred terms and strategies to disseminate EBT. Building upon prior phases, the current study (Phase 3) developed a user-informed infographic (128 words, 7th-grade level) focused on SU therapy. Parents were randomly assigned to view the user-informed infographic (n = 75) or a standard EBT description (n = 77) from the American Psychological Association (529 words, 12th-grade level). Logistic regressions examined the effect of marketing condition on parent-reported behavioral intentions and actual requests for EBT information, controlling for correlates of parent preferences in Phase 2 (parent education level; adolescent internalizing, externalizing, legal, and SU problems). Counter to hypotheses, condition did not have a main effect on either outcome. However, there was a significant interaction between condition and adolescent SU problems: among parents whose adolescents had SU problems, the user-informed infographic predicted 3.7 times higher odds of requesting EBT information than the standard description. Additionally, parents whose adolescents had legal problems were more likely to request EBT information than parents whose adolescents did not. The infographic was 4 times shorter and written at 5 grade levels lower, thereby providing a highly disseminable alternative. Findings highlight the value of specificity in DTC marketing, while advancing methods to create tailored marketing materials and communicate knowledge about psychological science.
A Theories-in-Use Approach to Building Marketing Theory
Creators: name: Jaworski, B.J.
name: Kohli, A.K.
name: Zeithaml, V.A.
name: Tuli, K.R.
name: Zaltman, G.
name: Ulaga, W.
Publisher: name: SAGE Publications Ltd
Year: 2020

description: This article’s objective is to inspire and provide guidance on the development of marketing knowledge based on the theories-in-use (TIU) approach. The authors begin with a description of the TIU approach and compare it with other inductive and deductive research approaches. The benefits of engaging in TIU-based research are discussed, including the development of novel organic marketing theories and the opportunity to cocreate relevant marketing knowledge with practitioners. Next, they review criteria for selecting research questions that are particularly well-suited for examination with TIU-based research. This is followed by detailed suggestions for TIU research: focusing on developing new constructs, theoretical propositions (involving antecedents, moderators, and consequences), and arguments for justifying theoretical propositions. A discussion of TIU tradecraft skills, validity checks, and limitations follows. The authors close with a discussion of future theory-building opportunities using the TIU approach.
Additional file 1 of Exploring visual pain trajectories in neck pain patients, using clinical course, SMS-based patterns, and patient characteristics: a cohort study
Creators: name: Irgens, Pernille
name: Myhrvold, Birgitte Lawaetz
name: Kongsted, Alice
name: Natvig, Bård
name: Vøllestad, Nina Køpke
name: Robinson, Hilde Stendal
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology
subject: Computational Biology

description: Additional file 1. Imputation of the weekly SMS data before classification and Classification into patterns and subgroups. Table S1 Definitions of the SMS-based patterns. Table S2 Association between the Visual trajectories and the 1-year SMS-based patterns (n = 888). Table S3 Association between the Visual trajectories and the last quarter SMS-based patterns (n = 888)
Description of the LC-MS/MS method for TAC determination in VAMS samples collected from kidney transplant pediatric patients
Creators: name: KOCUR, ARKADIUSZ
name: Marszałek, Dorota
Publisher: name: figshare
Year: 2022
Subjects: subject: 111503 Clinical Pharmacy and Pharmacy Practice
subject: FOS: Clinical medicine
subject: 111502 Clinical Pharmacology and Therapeutics

description: The file contain the LC-MS/MS (tandem mass liquid chromatography) method of TAC (tacrolimus) determination in VAMS (volumetric absorptive microsampling).
Dynamical influence of vortex-antivortex pairs in magnetic vortex oscillators
Creators: name: Otxoa, Rubén M.
name: Petit-Watelot, Sébastien
name: Manfrini, Mauricio
name: Thean, Aaron
name: Kim, Joo-Von
name: Devolder, Thibaut
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study the magnetization dynamics in a nanocontact magnetic vortex oscillators as function of temperature. Low temperature experiments reveal that the dynamics at low and high currents differ qualitatively. At low currents, we excite a temperature independent standard oscillation mode, consisting in the gyrotropic motion of a free layer vortex about the nanocontact. Above a critical current, a sudden jump of the frequency is observed, concomitant with a substantial increase of the frequency versus current slope factor. Using micromagnetic simulation and analytical modeling, we associate this new regime to the creation of a vortex-antivortex pair in the pinned layer of the spin valve. The vortex-antivortex distance depends on the Oersted field which favors a separation, and on the exchange bias field, which favors pair merging. The pair in the pinned layer provides an additional spin torque altering the dynamics of the free layer vortex, which can be quantitatively accounted for by an analytical model.
Valarie Zeithaml: autobiographical reflections
Creators: name: Zeithaml, V.A.
Publisher: name: Emerald Group Publishing Ltd.
Year: 2017

description: Purpose: By examining my personal development and career trajectory, I hope to share some insights into life as an academic. My particular path has contained, as most paths do, twists and turns. As I look back, they all seem somehow related to each other, but they were not all planned. Design/methodology/approach: I will discuss my life and career in chronological order, then reflect on my career and research philosophy. I will also discuss several of my most cited articles and how they emerged. Findings: I emphasize research that is both academically rigorous and relevant to business. I also show that passion for a subject, even one that is risky and not encouraged by others, has resulted in lifelong interest and inspiration for me. While not appropriate for all because of the risk, I found it worth taking a chance, largely because I was highly inspired by the subject. Practical implications: Research that is programmatic has benefits because it allows a scholar to own an area. Also, working with the right co-author teams – sometimes ones where different talents are distributed across the team is effective. Originality/value: The story and opinions are mine alone.
Additional file 4 of The Core Rehabilitation Outcome Set for Single-Sided Deafness (CROSSSD) study: International consensus on outcome measures for trials of interventions for adults with single-sided deafness
Creators: name: Katiri, Roulla
name: Hall, Deborah A.
name: Hoare, Derek J.
name: Fackrell, Kathryn
name: Horobin, Adele
name: Hogan, Nicholas
name: Buggy, Nóra
name: Van de Heyning, Paul H.
name: Firszt, Jill B.
name: Bruce, Iain A.
name: Kitterick, Pádraig T.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 4. Detailed plan and guidance document for consensus meeting
Targeting beclin1 as an adjunctive therapy against hiv using mannosylated polyethylenimine nanoparticles
Creators: name: Zhao, Y.
name: Karuppan, M.K.M.
name: Rodriguez, M.
name: El-Hage, N.
name: Batrakova, E.V.
name: Soler, Y.
Publisher: name: MDPI AG
Year: 2021

description: Using nanoparticle-based RNA interference (RNAi), we have previously shown that silenc-ing the host autophagic protein, Beclin1, in HIV-infected human microglia and astrocytes restricts HIV replication and its viral-associated inflammatory responses. Here, we confirmed the efficacy of Beclin1 small interfering RNA (siBeclin1) as an adjunctive antiviral and anti-inflammatory therapy in myeloid human microglia and primary human astrocytes infected with HIV, both with and without exposure to combined antiretroviral (cART) drugs. To specifically target human microglia and human astrocytes, we used a nanoparticle (NP) comprised of linear cationic polyethylenimine (PEI) conjugated with mannose (Man) and encapsulated with siBeclin1. The target specificity of the PEI-Man NP was confirmed in vitro using human neuronal and glial cells transfected with the NP encapsulated with fluorescein isothiocyanate (FITC). PEI-Man-siBeclin1 NPs were intranasally deliv-ered to healthy C57BL/6 mice in order to report the biodistribution of siBeclin1 in different areas of the brain, measured using stem-loop RT-PCR. Postmortem brains recovered at 1–48 h post-treatment with the PEI-Man-siRNA NP showed no significant changes in the secretion of the chemokines regulated on activation, normal T cell expressed and secreted (RANTES) and monocyte chemotactic protein-1 (MCP-1) and showed significant decreases in the secretion of the cytokines interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) when compared to phosphate-buffered saline (PBS)-treated brains. Nissl staining showed minimal differences between the neuronal structures when compared to PBS-treated brains, which correlated with no adverse behavioral affects. To confirm the brain and peripheral organ distribution of PEI-siBeclin1 in living mice, we used the In vivo Imaging System (IVIS) and demonstrated a significant brain accumulation of siBeclin1 through intranasal administration.
Description of the LC-MS/MS method for TAC determination in VAMS samples collected from kidney transplant pediatric patients
Creators: name: Kocur, Arkadiusz
name: Marszałek, Dorota
Publisher: name: figshare
Year: 2022
Subjects: subject: 111503 Clinical Pharmacy and Pharmacy Practice
subject: FOS: Clinical medicine
subject: 111502 Clinical Pharmacology and Therapeutics

description: The file contain the LC-MS/MS (tandem mass liquid chromatography) method of TAC (tacrolimus) determination in VAMS (volumetric absorptive microsampling).
Quaternary groundwater history in south eastern Australia: Lake Sunrise, NSW
Creators: name: Flanagan, Jack
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: The Murray-Darling Basin of south-eastern Australia contains a trove of rich paleoenvironmental relicts, representing the unique hydroclimatic conditions under which they formed. Lake systems contain sediment archives of depositional history in their nearshore and bordering dune (lunette) geomorphic landforms. Fluctuating periods of high lake levels with intermittent periods of deflation (and subsequent dune building) can be interpreted from the high-resolution stratigraphy preserved within these landforms. An ephemeral groundwater discharge lake, known as Lake Sunrise, lacking major fluvial connectivity, was chosen for this study. Nearby lake basins, such as the Willandra Lakes complex, rely on fluvial inflows, as well as groundwater fluctuations to produce 'lake full' conditions, however this relationship is poorly understood. By contrast, due to its isolation, Lake Sunrise responds to fluctuations in the regional groundwater table. A stratigraphic framework based on particle size, mineralogy, and single-grain optically stimulated luminescence (OSL) age estimates was developed. A series of clay lunettes was analysed, revealing oscillating periods of enhanced groundwater discharge throughout the late Quaternary, from ~ 90 ± 4 ka - 24 ± 1 ka. Comparing these findings to other regional proxies reveal that groundwater discharge basins experience a ~10,000 – 20,000 year 'lag' between regional groundwater recharge and surface discharge.
Extracellular Vesicles as Drug Carriers for Enzyme Replacement Therapy to Treat CLN2 Batten Disease: Optimization of Drug Administration Routes
Creators: name: Haney, M.J.
name: Jin, Y.S.
name: Zhao, Y.
name: Batrakova, E.V.
Publisher: name: NLM (Medline)
Year: 2020

description: CLN2 Batten disease (BD) is one of a broad class of lysosomal storage disorders that is characterized by the deficiency of lysosomal enzyme, TPP1, resulting in a build-up of toxic intracellular storage material in all organs and subsequent damage. A major challenge for BD therapeutics is delivery of enzymatically active TPP1 to the brain to attenuate progressive loss of neurological functions. To accomplish this daunting task, we propose the harnessing of naturally occurring nanoparticles, extracellular vesicles (EVs). Herein, we incorporated TPP1 into EVs released by immune cells, macrophages, and examined biodistribution and therapeutic efficacy of EV-TPP1 in BD mouse model, using various routes of administration. Administration through intrathecal and intranasal routes resulted in high TPP1 accumulation in the brain, decreased neurodegeneration and neuroinflammation, and reduced aggregation of lysosomal storage material in BD mouse model, CLN2 knock-out mice. Parenteral intravenous and intraperitoneal administrations led to TPP1 delivery to peripheral organs: liver, kidney, spleen, and lungs. A combination of intrathecal and intraperitoneal EV-TPP1 injections significantly prolonged lifespan in BD mice. Overall, the optimization of treatment strategies is crucial for successful applications of EVs-based therapeutics for BD.
Extracellular Vesicles in HIV, Drug Abuse, and Drug Delivery
Creators: name: Batrakova, E.
name: El-Hage, N.
name: Kumar, S.
Publisher: name: Springer
Year: 2020

description: Extracellular vesicles (EVs) are known to perform important biological functions and have been implicated in multiple disease pathogeneses, including HIV and drugs of abuse. EVs can carry biological molecules via biofluids such as plasma and cerebrospinal fluids (CSF) from healthy or disease organs to distant organs and deliver biomolecules to recipient cells that subsequently alter the physiology of the recipient organs. As biocarriers, EVs have the potential to be developed as non-invasive biomarkers for disease pathogenesis and drug abuse, as the level of specific EV components can be altered under disease/drug abuse conditions. Since many drugs don’t cross the blood-brain barrier, EVs have shown the potential to encapsulate small drug molecules, including nucleotides, and carry these drugs to brain cells and enhance brain drug bioavailability. Through this special issue, we have covered several studies related to the role of EVs in altering biological functions via cell-cell interactions in healthy, HIV, and drug of abuse conditions. We have also included studies on the role of EVs as potential biomarkers for HIV pathogenesis and drugs of abuse. Further, the potential role of EVs in drug delivery in the CNS for diseases, including HIV-associated neurocognitive disorders and other neurological disorders, are covered in this issue.
Pre-implantation Genetic Testing for Aneuploidy (PGT-A)
Creators: name: Wirawit Piyamongkol
Publisher: name: PIMDEE Co., Ltd.
Year: 2020
Subjects: comparative genomic hybridization microarray (aCGH)
embryo selection
next generation sequencing (NGS)
pre-implantation genetic testing for aneuploidy (PGT-A)
pre-implantation genetic screening (PGS)

description: Thai Journal of Obstetrics and Gynaecology, 28, 3, 130-135
Snowmass Neutrino Frontier: Neutrino Interaction Cross Sections (NF06) Topical Group Report
Creators: name: Balantekin, A. B.
name: Gardiner, S.
name: Mahn, K.
name: Mohayai, T.
name: Newby, J.
name: Pandey, V.
name: Zettlemoyer, J.
name: Asaadi, J.
name: Betancourt, M.
name: Harris, D. A.
name: Norrick, A.
name: Kling, Felix
name: Ramson, B.
name: Sanchez, M. C.
name: Fukuda, T.
name: Wallbank, M.
name: Wurm, M.
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2022
Subjects: neutrino: energy
neutrino: supernova
neutrino: interaction
electron: scattering
neutrino: scattering
neutrino: atmosphere
neutrino: energy spectrum
neutrino: detector
far detector
deep underground detector
DUNE
channel cross section: energy dependence
activity report

description: A thorough understanding of neutrino cross sections in a wide range of energies is crucial for the successful execution of the entire neutrino physics program. In order to extract neutrino properties, long-baseline experiments need an accurate determination of neutrino cross sections within their detector(s). Since very few of the needed neutrino cross sections across the energy spectrum are directly measured, we emphasize the need for theoretical input and indirect measurements such as electron scattering, which would complement direct measurements. In this report we briefly summarize the current status of our knowledge of the neutrino cross sections and articulate needs of the experiments, ongoing and planned, at energies ranging from CEvNS and supernova neutrino energies to the DUNE and atmospheric neutrino energies.
CRISIS HUMANITARIA EN COLOMBIA
Creators: name: JIMENEZ ARTEAGA, ADOLFO LEON
Publisher: name: Zenodo
Year: 2023

description: En este ensayo, se abordan los problemas arraigados de desigualdad y pobreza en Colombia, y se emprenderá una reflexión acerca de la necesidad imperante de implementar una agenda de acción para confrontar tales desafíos
Accuracy of Hemoglobin E Screening Test Using Allelic Discrimination Assay
Creators: name: Supranee Upanan
Publisher: name: PIMDEE Co., Ltd.
Year: 2020
Subjects: allelic discrimination
E screening test
hemoglobin E
real-time PCR

description: Thai Journal of Obstetrics and Gynaecology, 28, 3, 136-141
Additional file 5 of The Core Rehabilitation Outcome Set for Single-Sided Deafness (CROSSSD) study: International consensus on outcome measures for trials of interventions for adults with single-sided deafness
Creators: name: Katiri, Roulla
name: Hall, Deborah A.
name: Hoare, Derek J.
name: Fackrell, Kathryn
name: Horobin, Adele
name: Hogan, Nicholas
name: Buggy, Nóra
name: Van de Heyning, Paul H.
name: Firszt, Jill B.
name: Bruce, Iain A.
name: Kitterick, Pádraig T.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 5. Consenting participants’ characteristics and demographics
Macrophage-Derived Extracellular Vesicles as Drug Delivery Systems for Triple Negative Breast Cancer (TNBC) Therapy
Creators: name: Batrakova, E.V.
name: Zhao, Y.
name: Klyachko, N.L.
name: Jin, Y.S.
name: Li, S.M.
name: Bago, J.R.
name: Haney, M.J.
name: Kabanov, A.V.
Publisher: name: Springer
Year: 2020

description: Efficient targeted delivery of anticancer agents to TNBC cells remains one of the greatest challenges to developing therapies. The lack of tumor-specific markers, aggressive nature of the tumor, and unique propensity to recur and metastasize make TNBC tumors more difficult to treat than other subtypes. We propose to exploit natural ability of macrophages to target cancer cells by means of extracellular vesicles (EVs) as drug delivery vehicles for chemotherapeutic agents, paclitaxel (PTX) and doxorubicin (Dox). We demonstrated earlier that macrophage-derived EVs loaded with PTX (EV-PTX) and Dox (EV-Dox) target cancer cells and exhibited high anticancer efficacy in a mouse model of pulmonary metastases. Herein, we report a manufacture and characterization of novel EV-based drug formulations using different loading procedures that were optimized by varying pH, temperature, and sonication conditions. Selected EV-based formulations showed a high drug loading, efficient accumulation in TNBC cells in vitro, and pronounced anti-proliferation effect. Drug-loaded EVs target TNBC in vivo, including the orthotopic mouse T11 tumors in immune competent BALB/C mice, and human MDA-MB-231 tumors in athymic nu/nu mice, and abolished tumor growth. Overall, EV-based formulations can provide a novel solution to a currently unmet clinical need and reduce the morbidity and mortality of TNBC patients.
Beyond Mixing-length Theory: a step toward 321D
Creators: name: Arnett, W. David
name: Meakin, Casey
name: Viallet, Maxime
name: Campbell, Simon W.
name: Lattanzio, John
name: Mocák, Miroslav
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We examine the physical basis for algorithms to replace mixing-length theory (MLT) in stellar evolutionary computations. Our 321D procedure is based on numerical solutions of the Navier-Stokes equations. These implicit large eddy simulations (ILES) are three-dimensional (3D), time-dependent, and turbulent, including the Kolmogorov cascade. We use the Reynolds-averaged Navier-Stokes (RANS) formulation to make concise the 3D simulation data, and use the 3D simulations to give closure for the RANS equations. We further analyze this data set with a simple analytical model, which is non-local and time-dependent, and which contains both MLT and the Lorenz convective roll as particular subsets of solutions. A characteristic length (the damping length) again emerges in the simulations; it is determined by an observed balance between (1) the large-scale driving, and (2) small-scale damping. The nature of mixing and convective boundaries is analyzed, including dynamic, thermal and compositional effects, and compared to a simple model. We find that (1) braking regions (boundary layers in which mixing occurs) automatically appear {\it beyond} the edges of convection as defined by the Schwarzschild criterion, (2) dynamic (non-local) terms imply a non-zero turbulent kinetic energy flux (unlike MLT), (3) the effects of composition gradients on flow can be comparable to thermal effects, and (4) convective boundaries in neutrino-cooled stages differ in nature from those in photon-cooled stages (different Péclet numbers). The algorithms are based upon ILES solutions to the Navier-Stokes equations, so that, unlike MLT, they do not require any calibration to astronomical systems in order to predict stellar properties. Implications for solar abundances, helioseismology, asteroseismology, nucleosynthesis yields, supernova progenitors and core collapse are indicated.
description: 22 pages, 4 figures, 2 tables; significantly re-written, critique of Pasetto, et al. model added, accepted for publication by ApJ
Pflegeausbildung stärker auf wissenschaftliche Grundlagen stellen: Ein Plädoyer für curriculare Reformen und mehr Pflegebildungsforschung
Creators: name: Darmann-Finck, Ingrid
Publisher: name: Hogrefe
Year: 2017
Subjects: subject: Pflegeausbildung
subject: Pflegebildungsforschung
subject: Pflegeforschung
subject: Curriculare Reformen
subject: 610

description: -
Additional file 7 of The Core Rehabilitation Outcome Set for Single-Sided Deafness (CROSSSD) study: International consensus on outcome measures for trials of interventions for adults with single-sided deafness
Creators: name: Katiri, Roulla
name: Hall, Deborah A.
name: Hoare, Derek J.
name: Fackrell, Kathryn
name: Horobin, Adele
name: Hogan, Nicholas
name: Buggy, Nóra
name: Van de Heyning, Paul H.
name: Firszt, Jill B.
name: Bruce, Iain A.
name: Kitterick, Pádraig T.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 7. Detailed breakdown of the participant feedback
Can Video Enhance Confidence in Management of Vaginal Pessary: A randomized trial
Creators: name: Siwarut  Buakhom
Publisher: name: PIMDEE Co., Ltd.
Year: 2020
Subjects: confidence
pelvic organ prolapse
teaching video
vaginal pessary

description: Thai Journal of Obstetrics and Gynaecology, 28, 3, 152-159
Extracellular vesicle-based therapeutics: Preclinical and clinical investigations
Creators: name: Gololobova, O.A.
name: Batrakova, E.V.
name: Arzt, C.J.
name: Li, S.M.
name: Klyachko, N.L.
Publisher: name: MDPI AG
Year: 2020

description: Drug nanoformulations hold remarkable promise for the efficient delivery of therapeutics to a disease site. Unfortunately, artificial nanocarriers, mostly liposomes and polymeric nanoparticles, show limited applications due to the unfavorable pharmacokinetics and rapid clearance from the blood circulation by the reticuloendothelial system (RES). Besides, many of them have high cytotoxicity, low biodegradability, and the inability to cross biological barriers, including the blood brain barrier. Extracellular vesicles (EVs) are novel candidates for drug delivery systems with high bioavailability, exceptional biocompatibility, and low immunogenicity. They provide a means for intercellular communication and the transmission of bioactive compounds to targeted tissues, cells, and organs. These features have made them increasingly attractive as a therapeutic platform in recent years. However, there are many obstacles to designing EV-based therapeutics. In this review, we will outline the main hurdles and limitations for therapeutic and clinical applications of drug loaded EV formulations and describe various attempts to solve these problems.
Genetically modified macrophages accomplish targeted gene delivery to the inflamed brain in transgenic Parkin Q311X(A) mice: importance of administration routes
Creators: name: Wang, H.
name: Zhao, Y.
name: Karuppan, M.K.
name: Wang, M.
name: Haney, M.J.
name: Kabanov, A.V.
name: Batrakova, E.V.
name: Fay, J.
name: Li, Z.
name: El-Hage, N.
name: Lee, Y.Z.
name: Duhyeong, H.
Publisher: name: Nature Research
Year: 2020

description: Cell-based drug delivery systems have generated an increasing interest in recent years. We previously demonstrated that systemically administered macrophages deliver therapeutics to CNS, including glial cell line-derived neurotrophic factor (GDNF), and produce potent effects in Parkinson’s disease (PD) mouse models. Herein, we report fundamental changes in biodistribution and brain bioavailability of macrophage-based formulations upon different routes of administration: intravenous, intraperitoneal, or intrathecal injections. The brain accumulation of adoptively transferred macrophages was evaluated by various imaging methods in transgenic Parkin Q311(X)A mice and compared with those in healthy wild type littermates. Neuroinflammation manifested in PD mice warranted targeting macrophages to the brain for each route of administration. The maximum amount of cell-carriers in the brain, up to 8.1% ID/g, was recorded followed a single intrathecal injection. GDNF-transfected macrophages administered through intrathecal route provided significant increases of GDNF levels in different brain sub-regions, including midbrain, cerebellum, frontal cortex, and pons. No significant offsite toxicity of the cell-based formulations in mouse brain and peripheral organs was observed. Overall, intrathecal injection appeared to be the optimal administration route for genetically modified macrophages, which accomplished targeted gene delivery, and significant expression of reporter and therapeutic genes in the brain.
Prevalence of Maternal Hypovitaminosis D and Obstetric Outcomes at Chonprathan Hospital, Nonthaburi, Thailand
Creators: name: Porntita  Lersbuasin
Publisher: name: PIMDEE Co., Ltd.
Year: 2020
Subjects: vitamin D deficiency in pregnancy
vitamin D insufficiency in pregnancy
obstetric outcomes

description: Thai Journal of Obstetrics and Gynaecology, 28, 3, 167-174
Additional file 1 of Clinical validation of a population-based input function for 20-min dynamic whole-body 18F-FDG multiparametric PET imaging
Creators: name: Dias, André H.
name: Smith, Anne M.
name: Shah, Vijay
name: Pigg, David
name: Gormsen, Lars C.
name: Munk, Ole L.
Publisher: name: figshare
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Additional file 1: Paper supplemental Figs. S1, S2, S3, S4, and S5 and supplemental Tables S1, S2, and S3.