cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Real-world evidence on sodium-glucose cotransporter-2 inhibitor use and risk of Fournier's gangrene
Creators: name: Stürmer, T.
name: Pate, V.
name: Buse, J.B.
name: Yang, J.Y.
name: Wang, T.
Publisher: name: BMJ Publishing Group
Year: 2020

description: Background Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have been associated with increased occurrence of Fournier's gangrene (FG), a rare but serious form of necrotizing fasciitis, leading to a warning from the Food and Drug Administration. Real-world evidence on FG is needed to validate this warning. Methods We used data from IBM MarketScan (2013-2017) to compare the incidence of FG among adult patients who initiated either SGLT2i, a dipeptidyl peptidase-4 inhibitor (DPP4i), or any non-SGLT2i antihyperglycemic medication. FG was defined using inpatient International Classification of Diseases, Ninth Edition and Tenth Edition diagnosis codes 608.83 and N49.3, respectively, combined with procedure codes for debridement, surgery, or systemic antibiotics. We estimated crude incidence rates (IRs) using Poisson regression, and crude and adjusted HRs (aHR) and 95% CIs using standardized mortality ratio-weighted Cox proportional hazards models. Sensitivity analyses examined the impact of alternative outcome definitions. Results We identified 211 671 initiators of SGLT2i (n=93 197) and DPP4i (n=118 474), and 305 329 initiators of SGLT2i (n=32 868) and non-SGLT2i (n=272 461). Crude FG IR ranged from 3.2 to 3.8 cases per 100 000 person-years during a median follow-up of 0.51-0.58 years. Compared with DPP4i, SGLT2i initiation was not associated with increased risk of FG for any outcome definition, with aHR estimates ranging from 0.25 (0.04-1.74) to 1.14 (0.86-1.51). In the non-SGLT2i comparison, we observed an increased risk of FG for SGLT2i initiators when using FG diagnosis codes alone, using all diagnosis settings (aHR 1.80; 0.53-6.11) and inpatient diagnoses only (aHR 4.58; 0.99-21.21). Conclusions No evidence of increased risk of FG associated with SGLT2i was observed compared with DPP4i, arguably the most relevant clinical comparison. However, uncertainty remains based on potentially higher risk in the broader comparison with all non-SGLT2i antihyperglycemic agents and the rarity of FG. Trial registration number EUPAS Register Number 30018.
Second order geometric flows on foliated manifolds
Creators: name: Bedulli, Lucio
name: He, Weiyong
name: Vezzoni, Luigi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 53C44, 53C12, 53C25

description: We prove a general result about the short time existence and uniqueness of second order geometric flows transverse to a Riemannian foliation on a compact manifold. Our result includes some flows already existing in literature, as the transverse Ricci flow, the Sasaki-Ricci flow and the Sasaki J-flow and motivates the study of other evolution equations. We also introduce a transverse version of the Kaehler-Ricci flow adapting some classical results to the foliated case.
description: 22 pages. Comments are wellcome
title: Mammographic evaluation of male breast swelling - A pictorial review.
Creators: name: Gopinathan, Nikhil
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Breast
subject: Oncology
subject: Mammography
subject: Imaging sequences
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Gynecomastia and breast cancer are the twomost important diseases of the male breast.The low incidence of breast cancer in males does not warrant screening mammography and, therefore, mammography in males is a diagnostic study. Patients with...
(101425) Richard Robert McDaniel
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Glomerular Filtration Rate and Associated Risks of Cardiovascular Events, Mortality, and Severe Hypoglycemia in Patients with Type 2 Diabetes: Secondary Analysis (DEVOTE 11)
Creators: name: McGuire, D.K.
name: Poulter, N.R.
name: Pratley, R.E.
name: Jia, T.
name: Pop-Busui, R.
name: Hansen, M.B.
name: Amod, A.
name: Pieber, T.R.
name: Zinman, B.
name: Buse, J.B.
name: Mark, T.
name: The DEVOTE Study Group
Publisher: name: Adis
Year: 2020

description: Introduction: The associations of chronic kidney disease (CKD) severity, cardiovascular disease (CVD), and insulin with the risks of major adverse cardiovascular events (MACE), mortality, and severe hypoglycemia in patients with type 2 diabetes (T2D) at high cardiovascular (CV) risk are not known. This secondary, pooled analysis of data from the DEVOTE trial examined whether baseline glomerular filtration rate (GFR) categories were associated with a higher risk of these outcomes. Methods: DEVOTE was a treat-to-target, double-blind trial involving 7637 patients with T2D at high CV risk who were randomized to once-daily treatment with either insulin degludec (degludec) or insulin glargine 100 units/mL (glargine U100). Patients with estimated GFR data at baseline (n = 7522) were analyzed following stratification into four GFR categories. Results: The risks of MACE, CV death, and all-cause mortality increased with worsening baseline GFR category (P < 0.05), with a trend towards higher rates of severe hypoglycemia. Patients with prior CVD, CKD (estimated GFR < 60 mL/min/m2), or both were at higher risk of MACE, CV death, and all-cause mortality. Only CKD was associated with a higher rate of severe hypoglycemia, and the risk of MACE was higher in patients with CVD than in those with CKD (P = 0.0003). There were no significant interactions between randomized treatment and GFR category. Conclusion: The risks of MACE, CV death, and all-cause mortality were higher with lower baseline GFR and with prior CVD, CKD, or both. The relative effects of degludec versus glargine U100 on outcomes were consistent across baseline GFR categories, suggesting that the lower rate of severe hypoglycemia associated with degludec use versus glargine U100 use was independent of baseline GFR category. Funding: Novo Nordisk.
(101426) Thomas Pinchbeck
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Field-controlled columnar and planar patterning of cholesteric colloids
Creators: name: D'Adamo, Giuseppe
name: Marenduzzo, D.
name: Micheletti, C.
name: Orlandini, E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We study how dispersions of colloidal particles in a cholesteric liquid crystal behave under a time-dependent electric field. By controlling the amplitude and shape of the applied field wave, we show that the system can be reproducibly driven out of equilibrium through different kinetic pathways and navigated through a glassy-like free energy landscape encompassing many competing metastable equilibria. Such states range from simple Saturn rings to complex structures featuring amorphous defect networks, or stacks of disclination loops. A non-equilibrium electric field can also trigger the alignment of particles into columnar arrays, through defect-mediated force impulses, or their repositioning within a plane. Our results are promising in terms of providing new avenues towards controlled patterning and self-assembly of soft colloid-liquid crystal composite materials.
description: 5 pages, 4 figures. Phys. Rev. Lett., 2015, in press
Social Science Alumni Stories: Pathways into Policy
Creators: name: Carter, Jackie
Publisher: name: National Teaching Repository
Year: 2023
Subjects: classificationCode: 440712
subject: Social policy
classificationCode: 440706
subject: Health policy
classificationCode: 440705
subject: Gender, policy and administration
classificationCode: 440701
subject: Communications and media policy
classificationCode: 440707
subject: Housing policy
classificationCode: 440799
subject: Policy and administration not elsewhere classified
classificationCode: 440710
subject: Research, science and technology policy
classificationCode: 440709
subject: Public policy

description: This collection of 18 alumni stories from the University of Manchester evidences how former social science students have graduated into roles in research careers.
 Using a skills framework developed by the author - covering analytical and research skills relevant to SHAPE (Social Science, Humanities and Arts for People and the Economy) graduates, and professional (or 'employability' or 'soft') skills taken from industry reports, each story reflects how an alumni looks back on what they learned in their degree and reflects on how they are using that knowledge and those skills in their current role.
 The aim is to help current students to look forward, to appreciate the skills they are learning have value in the workplace, and to show them through their peers of a few years hence how their futures could unfold.
 The booklet draws on the author's experience of developing a reflection framework for her own students who undertake work placements, and helping them use this to imagine their futures.
 All contributors have granted permission for the booklet and their stories to be shared openly.
 The booklet is one of two - the other being 'Pathways into Research'. A third is in preparation 'Pathways into Data Careers'
 DOI: 10.25416/NTR.24036921
Inpatient Transition to Virtual Care During COVID-19 Pandemic
Creators: name: Jones, M.S.
name: Alexander, B.E.
name: Keller, S.B.
name: Goley, A.L.
name: Buse, J.B.
name: Caldwell, M.M.
Publisher: name: Mary Ann Liebert Inc.
Year: 2020

description: Introduction: During the coronavirus disease 2019 (COVID-19) outbreak, novel approaches to diabetes care have been employed. Care in both the inpatient and outpatient setting has transformed considerably. Driven by the need to reduce the use of personal protective equipment and exposure for patients and providers alike, we transitioned inpatient diabetes management services to largely "virtual" or remotely provided care at our hospital. Methods: Implementation of a diabetes co-management service under the direction of the University of North Carolina division of endocrinology was initiated in July 2019. In response to the COVID-19 pandemic, the diabetes service was largely transitioned to a virtual care model in March 2020. Automatic consults for COVID-19 patients were implemented. Glycemic outcomes from before and after transition to virtual care were evaluated. Results: Data over a 15-week period suggest that using virtual care for diabetes management in the hospital is feasible and can provide similar outcomes to traditional face-to-face care. Conclusion: Automatic consults for COVID-19 patients ensure that patients with serious illness receive specialized diabetes care. Transitioning to virtual care models does not limit the glycemic outcomes of inpatient diabetes care and should be employed to reduce patient and provider exposure in the setting of COVID-19. These findings may have implications for reducing nosocomial infection in less challenging times and might address shortage of health care providers, especially in the remote areas.
title: Spermatic cord: the largely forgotten with much to say
Creators: name: Solano Romero, Alba Patricia
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Diagnostic procedure
subject: Ultrasound
subject: Abdomen
subject: Biological effects

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To highlight the role of the spermatic cord in the diagnosis of certain scrotal diseases and provide fair examples of different spermatic cord...
title: Contrast Enhanced Spectral Mammography (CESM) as an alternative for local study of breast cancer.
Creators: name: GIL BERNAL, AURORA
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Cancer
subject: Statistics
subject: Contrast agent-intravenous
subject: Biopsy
subject: Ultrasound
subject: Mammography
subject: Breast

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Contrast Enhanced Spectral Mammography (CESM) is a relatively new technique in the diagnosis of breast cancer. It includes obtaining two radiographic images: after intravenous contrast injection, a Full-Field Digital Mammography (FFDM) and a...
title: The phyllodes tumors of the breast.
Creators: name: Aouini, Rim
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Breast
subject: Oncology
subject: Mammography
subject: Ultrasound
subject: Biopsy
subject: Cancer

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The aim of this exhibit is to review the imaging findings and to illustrate the radiological signs that could suggest benignity or malignancy of phyllodes...
Validation of distinct type 2 diabetes clusters and their association with diabetes complications in the DEVOTE, LEADER and SUSTAIN-6 cardiovascular outcomes trials
Creators: name: Buse, J.B.
name: Wolthers, B.O.
name: Kreiner, F.F.
name: Geybels, M.S.
name: Marx, N.
name: Kahkoska, A.R.
name: Klein, K.R.
name: Pratley, R.E.
name: Nauck, M.A.
Publisher: name: Blackwell Publishing Ltd
Year: 2020

description: Aims: To validate the clusters of Swedish individuals with recent-onset diabetes at differential risk of complications, which were identified in a previous study, in three global populations with long-standing type 2 diabetes (T2D) who were at high cardiovascular risk, and to test for differences in the risk of major diabetes complications and survival endpoints. Materials and methods: We assigned participants from recent global outcomes trials (DEVOTE [n = 7637], LEADER [n = 9340] and SUSTAIN-6 [n = 3297]) to the previously defined clusters according to age at diabetes diagnosis, baseline glycated haemoglobin (HbA1c) and body mass index (BMI). Outcomes were assessed using Kaplan–Meier analysis and log-rank tests. Results: The T2D clusters were consistently replicated across the three trial cohorts. The risk of major adverse cardiovascular events and cardiovascular death differed significantly, in all trials, across clusters over a median follow-up duration of 2.0, 3.8 and 2.1 years, respectively, and was highest for the cluster of participants with high HbA1c and low BMI (P < 0.05 in DEVOTE and LEADER). In LEADER and SUSTAIN-6, the risk of nephropathy differed across clusters (P < 0.0001 and P = 0.003, respectively). The risk of severe hypoglycaemia differed in DEVOTE (P = 0.006). Conclusions: Previously identified clusters can be replicated in three geographically diverse cohorts of long-standing T2D and are associated with cluster-specific risk profiles for additional clinical and survival outcomes, providing further validation of the clustering methodology. The external validity and stability of clusters across cohorts provides a premise for future work to optimize the clustering approach to yield T2D subgroups with maximum predictive validity who may benefit from subtype-specific treatment paradigms.
title: Imaging features of adenoid cystic carcinoma: common and uncommon sites.
Creators: name: de Andrade Corona, Camila
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Neoplasia
subject: Cancer
subject: Diagnostic procedure
subject: Ultrasound
subject: MR
subject: Mammography
subject: Thorax
subject: Head and neck
subject: Breast

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: to review the main imaging findings of adenoid cystic carcinomas (ACCs) involving the salivary glands, the breast and other unusual sites. to describe its histological patterns, the clinical and epidemiological aspects, emphasizing the differences...
title: MRI screening in High Risk family history population- cancers detected and false positive recalls within an NHS screening programme
Creators: name: Al-Attar, Miaad
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Quality assurance
subject: Screening
subject: MR
subject: Breast

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: 1- Review theMRI appearances of cancers detected as part of a high risk screening programme 2- Review MRI appearances of benign lesions assessed (false positive recall) in an attempt to reduce recall rate and improve programme...
(101422) Margaret McDaniel
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Pair Production of Scalar Leptoquarks at the LHC to NLO Parton Shower Accuracy
Creators: name: Mandal, Tanumoy
name: Mitra, Subhadip
name: Seth, Satyajit
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We present the scalar leptoquark pair production process at the LHC computed at the next-to-leading order in QCD, matched to the PYTHIA parton shower using the MC@NLO formalism. We consider the leading order decay of a leptoquark to a lepton ($e,μ,τ$ or $ν_e,ν_μ,ν_τ$) and a jet and observe the effects of parton shower on the final states. For demonstration, we display the kinametical distributions of a selection of observables along with their scale uncertainties for the 13 TeV LHC. We also present pair production cross sections and $K$-factors using massless five-quark flavor scheme for different LHC center-of-mass energies. The complete stand-alone code is available online.
description: 9 pages, 2 tables, 6 figures. Typos fixed. Similar to the PRD version. Analysis/program extended to all generations
The effect of glucagon-like peptide-1 receptor agonists liraglutide and semaglutide on cardiovascular and renal outcomes across baseline blood pressure categories: Analysis of the LEADER and SUSTAIN 6 trials
Creators: name: Bhatt, D.L.
name: Pratley, R.E.
name: Leiter, L.A.
name: Vrazic, H.
name: Bain, S.C.
name: Verma, S.
name: Ripa, M.S.
name: Mazer, C.D.
name: Rasmussen, S.
name: Buse, J.B.
Publisher: name: Blackwell Publishing Ltd
Year: 2020

description: It is unknown if the cardioprotective and renal effects of glucagon-like peptide-1 receptor agonists are consistent across blood pressure (BP) categories in patients with type 2 diabetes and at high risk of cardiovascular events. Using data from the LEADER (9340 patients) and SUSTAIN 6 (3297 patients) trials, we evaluated post hoc the cardiorenal effect of liraglutide and semaglutide on major adverse cardiovascular events (MACE) and nephropathy by baseline BP categories using a Cox proportional hazards model (treatment and subgroup as factors; adjusted for cardiorenal risk factors). Data from the two trials were analysed separately. In the LEADER and SUSTAIN 6 trials, the prevalence of stage 1 hypertension was 30% and 31%, respectively, and of stage 2 hypertension 41% and 43%, respectively. There was no statistical heterogeneity across the BP categories for the effects of liraglutide (P =.06 for MACE; P =.14 for nephropathy) or semaglutide (P =.40 for MACE; P =.27 for nephropathy) versus placebo. This implies that liraglutide and semaglutide may be beneficial for patients with type 2 diabetes, irrespective of their baseline BP.
STROBE checklist for ‘Survival status and predictors of mortality among mechanically ventilated COVID-19 patients in Addis Ababa COVID-19 Care Centers, Ethiopia’
Creators: name: Sibhat, Migbar
Publisher: name: figshare
Year: 2022
Subjects: subject: Diseases
subject: 110310 Intensive Care
subject: FOS: Clinical medicine
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Completed STROBE checklist for ‘Survival status and predictors of mortality among mechanically ventilated COVID-19 patients in Addis Ababa COVID-19 Care Centers, Ethiopia
title: Imaging study of hearing loss in pediatric patients before cochlear implantation: what the radiologist needs to know
Creators: name: Ibáñez Caturla, Santiago
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Ear / Nose / Throat
subject: Paediatric
subject: Anatomy
subject: CT
subject: MR
subject: eLearning
subject: Education
subject: Image compression
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To review the normal anatomy of inner and middle ear with emphasis on regions with influence on the implantation procedure To provide a brief overview of device and technique for cochlear implantation To outline relevant imaging findings in...
Impact of microvascular disease on cardiovascular outcomes in type 2 diabetes: Results from the LEADER and SUSTAIN 6 clinical trials
Creators: name: Sejersten Ripa, M.
name: Honoré, J.B.
name: Rasmussen, S.
name: Buse, J.B.
name: Zinman, B.
name: Bain, S.C.
name: Verma, S.
name: Pratley, R.E.
name: Mann, J.F.E.
name: Nauck, M.A.
Publisher: name: Blackwell Publishing Ltd
Year: 2020

description: The randomized, double-blind, cardiovascular outcomes trials LEADER (NCT01179048) and SUSTAIN 6 (NCT01720446) showed cardiovascular risk reduction in patients with type 2 diabetes treated with liraglutide and semaglutide, respectively, compared with placebo. This post hoc analysis examined the impact of microvascular disease at baseline on cardiovascular outcomes in these trials, and the efficacy of liraglutide (1.8 mg) and once-weekly semaglutide (0.5-1.0 mg) in patients with and without microvascular disease. In total, 9340 patients from LEADER and 3297 patients from SUSTAIN 6 were included in this analysis; of these, 5761 and 2356 had a history of microvascular disease at baseline and 3835 and 1640 had a history of both microvascular and macrovascular disease, respectively. Patients with microvascular disease were shown to have an increased risk of major adverse cardiovascular events compared with patients without microvascular disease (hazard ratio [95% confidence interval] in LEADER: 1.15 [1.03; 1.29], P =.0136; SUSTAIN 6: 1.56 [1.14; 2.17], P =.0064). Liraglutide and semaglutide consistently reduced cardiovascular risk in patients with and without microvascular disease.
title: Axial skeleton tumors: Orphan of pediatric oncology?
Creators: name: Jain, Nikshita
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Neoplasia
subject: Biopsy
subject: MR
subject: CT
subject: Conventional radiography
subject: Paediatric
subject: Musculoskeletal bone

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Overview of the epidemiology and clinical approach to bone tumors in children Emphasis on the tumors presenting with axial skeleton involvement Salient features of each,on radiography and CT/MR where indicated, with a pictorial review of the...
title: Routine Radiomics – Utilizing Routine Chest CT Imaging Data for the Discovery of Predictive Markers
Creators: name: Röhrich, Sebastian
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Osteoporosis
subject: Chronic obstructive airways disease
subject: Computer Applications-General
subject: CAD
subject: CT-Quantitative
subject: CAD
subject: Thorax
subject: Lung
subject: Bones

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To appreciate conditions visible in chest CTs where a radiomics approach may discover predictive markers. To know the current gaps in knowledge and determine the next steps to apply radiomics to routine data. To become familiar with data sources...
(101418) Josephine Emma Ann McDaniel
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: The role of 4D CT in the diagnosis of atypically located parathyroid adenomas in patients with primary hyperparathyroidism.
Creators: name: Urina, Marina
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Head and neck
subject: Thyroid / Parathyroids
subject: CT
subject: Ultrasound
subject: Diagnostic procedure
subject: Contrast agent-intravenous
subject: Endocrine disorders
subject: Osteoporosis

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Primary hyperparathyroidism is the unregulated overproduction of parathyroid hormone (PTH) resulting in abnormal calcium homeostasis. It is commonly caused by parathyroid adenomas. Primary hyperparathyroidism is rarely caused by parathyroid...
Investigating and understanding the effects of multiple femtosecond laser scans on the surface topography of metallic specimens
Creators: name: Ling, Edwin Jee Yang
name: Saïd, Julien
name: Brodusch, Nicolas
name: Gauvin, Raynald
name: Servio, Phillip
name: Kietzig, Anne-Marie
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The majority of studies performed on the formation of surface features by femtosecond laser radiation focuses on single scan procedures, i.e. solely manipulating the laser beam once over the target area to fabricate different surface topographies. In this work, the effect of scanning stainless steel 304 multiple times with femtosecond laser pulses is thoroughly investigated over a wide range of fluences. The resultant laser-induced surface topographies can be categorized into two different regimes. In the low fluence regime $(F_{Σline,max} < 130 ~J/cm^2)$, ellipsoidal cones (randomly distributed surface protrusions covered by several layers of nanoparticles) are formed. Based on chemical, crystallographic, and topographical analyses, we conclude that these ellipsoidal cones are composed of unablated steel whose conical geometry offers a significant degree of fluence reduction (35-52%). Therefore, the rest of the irradiated area is preferentially ablated at a higher rate than the ellipsoidal cones. The second, or high fluence regime $(F_{Σline,max} > 130~ J/cm^2)$ consists of laser-induced surface patterns such as columnar and chaotic structures. Here, the surface topography showed little to no change even when the target was scanned repeatedly. This is in stark contrast to the ellipsoidal cones in the first regime, which evolve and grow continuously as more laser passes are applied.
title: Comparison between 18F-FDG PET/CT scan and CT scan in the diagnosis of liver metastases
Creators: name: Saftencu, Mihai
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Metastases
subject: Molecular imaging
subject: Contrast agent-intravenous
subject: PET-CT
subject: CT
subject: Oncology
subject: Liver
subject: Hybrid Imaging

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Positron emission tomography-computed tomography (PET-CT) with fluorine-18 fluorodeoxyglucose (18F-FDG) is a heavily used morphofunctional imaging method in oncology for the evaluation and management of several types of cancer(1).18F-FDG PET-CT...
Risk of severe hypoglycaemia and its impact in type 2 diabetes in DEVOTE
Creators: name: Lingvay, I.
name: Buse, J.B.
name: Poulter, N.R.
name: Lange, M.
name: Pieber, T.R.
name: Kvist, K.
name: Hachmann-Nielsen, E.
name: Moses, A.C.
name: Marso, S.P.
name: Heller, S.
name: Pratley, R.E.
name: Philis-Tsimikas, A.
name: Andresen, M.T.
Publisher: name: Blackwell Publishing Ltd
Year: 2020

description: Aims: To undertake a post-hoc analysis, utilizing a hypoglycaemia risk score based on DEVOTE trial data, to investigate if a high risk of severe hypoglycaemia was associated with an increased risk of cardiovascular events, and whether reduced rates of severe hypoglycaemia in patients identified as having the highest risk affected the risk of cardiovascular outcomes. Materials and Methods: The DEVOTE population was divided into quartiles according to patients' individual hypoglycaemia risk scores. For each quartile, the observed incidence and rate of severe hypoglycaemia, major adverse cardiovascular event (MACE) and all-cause mortality were determined to investigate whether those with the highest risk of hypoglycaemia were also at the greatest risk of MACE and all-cause mortality. In addition, treatment differences within each risk quartile [insulin degludec (degludec) vs. insulin glargine 100 units/mL (glargine U100)] in terms of severe hypoglycaemia, MACE and all-cause mortality were investigated. Results: Patients with the highest risk scores had the highest rates of severe hypoglycaemia, MACE and all-cause mortality. Treatment ratios between degludec and glargine U100 in the highest risk quartile were 95% confidence interval (CI) 0.56 (0.39; 0.80) (severe hypoglycaemia), 95% CI 0.76 (0.58; 0.99) (MACE) and 95% CI 0.77 (0.55; 1.07) (all-cause mortality). Conclusions: The risk score demonstrated that a high risk of severe hypoglycaemia was associated with a high incidence of MACE and all-cause mortality and that, in this high-risk group, those treated with degludec had a lower incidence of MACE. These observations support the hypothesis that hypoglycaemia is a risk factor for cardiovascular events.
title: Is benign breast calcification really benign? An analytical study of Breast Arterial Calcifications (BAC) on Mammography in Indian population.
Creators: name: Kamble, Akshaykumar
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Arteriosclerosis
subject: Health policy and practice
subject: Mammography
subject: Breast

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To find prevalence of breast arterial calcification (BAC) in Indian Population. To find contribution of BAC in benign breast calcifications. To classify breast arterial calcificaitons (BACs). To find association of diabetes and hypertension with...
title: Up-to-date in the renal cell carcinoma radiological follow up
Creators: name: Tomás Muñoz, Pablo
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Abdomen
subject: Kidney
subject: Ultrasound
subject: MR
subject: CT
subject: Chemotherapy
subject: Cancer
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The aim of this presentation is to discuss about the different options in the treated renal cell carcinoma (RCC) follow-up based on the main urological and radiological guidelines reviewed. Different follow-up protocols obtained from these...
Schrödinger Operators With $A_\infty$ Potentials
Creators: name: Raich, Andrew
name: Tinker, Michael
Publisher: name: arXiv
Year: 2015
Subjects: subject: Analysis of PDEs (math.AP)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 35K08, 35J10, 32W30

description: We study the heat kernel $p(x,y,t)$ associated to the real Schrödinger operator $H = -Δ+ V$ on $L^2(\mathbb{R}^n)$, $n \geq 1$. Our main result is a pointwise upper bound on $p$ when the potential $V \in A_\infty$. In the case that $V\in RH_\infty$, we also prove a lower bound. Additionally, we compute $p$ explicitly when $V$ is a quadratic polynomial.
description: 15 pages. Comments welcome!
title: Dual-energy CT (DECT) myocardial delayed enhancement (MDE) in the assessment of cardiac diseases
Creators: name: Pershina, Ekaterina
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Comparative studies
subject: CT-High Resolution
subject: CT
subject: Cardiac
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To review the diagnostic value of cardiac DECT MDE in different cardiac diseases. To understand post-processing for DECT. To describe the MDE patterns in ischemic and non-ischemic heart diseases, cardiac neoplasms and...
(101420) Harriet McDaniel
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Imaging findings in primary and secondary sclerosing cholangiopathy
Creators: name: Vella, Stephanie
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Inflammation
subject: Infection
subject: Diagnostic procedure
subject: SPECT
subject: MR
subject: CT
subject: Liver
subject: Biliary Tract / Gallbladder
subject: Ischaemia / Infarction

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To illustrate MRI and CT features of primary and secondary sclerosing cholangiopathy (SC). To highlight clinicoradiological features that might indicate the aetiology in secondary...
Large spaces of bounded rank matrices revisited
Creators: name: Pazzis, Clément de Seguins
Publisher: name: arXiv
Year: 2015
Subjects: subject: Rings and Algebras (math.RA)
subject: FOS: Mathematics
subject: 15A03, 15A30

description: Let $n,p,r$ be positive integers with $n \geq p\geq r$. A rank-$\overline{r}$ subset of $n$ by $p$ matrices (with entries in a field) is a subset in which every matrix has rank less than or equal to $r$. A classical theorem of Flanders states that the dimension of a rank-$\overline{r}$ linear subspace must be less than or equal to $nr$, and it characterizes the spaces with the critical dimension $nr$. Linear subspaces with dimension close to the critical one were later studied by Atkinson, Lloyd and Beasley over fields with large cardinality; their results were recently extended to all fields. Using a new method, we obtain a classification of rank-$\overline{r}$ affine subspaces with large dimension, over all fields. This classification is then used to double the range of (large) dimensions for which the structure of rank $\overline{r}$-linear subspaces is known for all fields.
description: 78 pages
title: Assessment of the SecurAcath® device in reducing migration of drainage catheters in biliary and renal intervention.
Creators: name: Hughes, Peter
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Outcomes
subject: Drainage
subject: Complications
subject: Catheters
subject: Fluoroscopy
subject: Kidney
subject: Interventional non-vascular
subject: Biliary Tract / Gallbladder

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Dislodgement of drainage and vascular access catheters is a significant problem resulting in unnecessary repeat procedures and interruption of therapy for patients and placing a strain on the finite resources of Interventional Radiology departments....
Comprehensive Pulmonary Safety Review of Inhaled Technosphere® Insulin in Patients with Diabetes Mellitus
Creators: name: Buse, J.B.
name: Steiner, S.
name: Peters, A.
name: Tran, T.
name: Kendall, D.M.
name: McGill, J.B.
name: Pompilio, F.M.
Publisher: name: Adis
Year: 2020

description: Background and Objective: Technosphere® Insulin (TI), a human insulin powder for inhalation (Afrezza®; MannKind Corporation, Westlake Village, CA, USA), is an ultra-rapid-acting inhaled insulin indicated to improve postprandial glycemic control in patients with type 1 or type 2 diabetes mellitus (T1DM or T2DM). Because TI is absorbed across the alveolar membrane, the objective of this analysis was to characterize its pulmonary safety. Methods: Pooled data from 13 phase 2/3 clinical studies in 5505 patients with T1DM or T2DM treated with TI, Technosphere inhalation powder without insulin (TP; placebo), or active-comparator treatment were analyzed for incidences of respiratory treatment-emergent adverse events (TEAEs), changes in pulmonary function, and lung malignancies. Radiographic changes in the lungs were monitored in a subset of 229 patients. Results: Among 3017 patients receiving TI, the median duration of TI exposure was 168 days; median active-comparator and TP exposure durations were 363 and 149 days for 2198 and 290 patients, respectively. Respiratory TEAEs were comparable across treatments, except for a higher incidence of mild cough with TI in active-comparator studies (28.0% vs. 5.2%). Slight reversible declines in pulmonary function from baseline were observed for TI versus TP and active-comparator treatments, including in a subpopulation of patients with retrospectively identified lung dysfunction. Lung malignancies were reported in two patients on active TI therapy with a smoking history. No clinically significant changes from baseline were observed in radiographic images. Conclusions: Pulmonary safety assessment of the TI inhalation system did not identify any safety issues in individuals with either T1DM or T2DM.
title: Cancer Immunotherapy – What The Radiologist Needs To Know
Creators: name: Harrington, Kate
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Oncology
subject: Thorax
subject: Abdomen
subject: CT
subject: Treatment effects
subject: Cancer
subject: Biological effects
subject: Drugs / Reactions

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Describe the clinical background of immunotherapy in cancer treatment. Outline the novel patterns of treatment response observed in patients receiving immunotherapy and discuss the immune-related response criteria (irRC). Recognize the imaging...
title: Decoding Cerebellopontine angle tumors : A familiar dilemma!
Creators: name: Pangarkar, Sayali
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: CNS
subject: Neuroradiology brain
subject: CT
subject: MR
subject: Diagnostic procedure
subject: Cancer
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: 1. Understanding the imaging characteristics of common and uncommon cerebello-pontine angle (CPA) tumours. 2. Case based discussion, with morphological characterisation and histopathological correlation. 3. Structured reporting checklist to enable...
(101421) David McDaniel
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Glucose-Responsive Insulin and Delivery Systems: Innovation and Translation
Creators: name: Kahkoska, A.R.
name: Wang, Z.
name: Yu, J.
name: Buse, J.B.
name: Wang, J.
name: Gu, Z.
Publisher: name: Wiley-VCH Verlag
Year: 2020

description: Type 1 and advanced type 2 diabetes treatment involves daily injections or continuous infusion of exogenous insulin aimed at regulating blood glucose levels in the normoglycemic range. However, current options for insulin therapy are limited by the risk of hypoglycemia and are associated with suboptimal glycemic control outcomes. Therefore, a range of glucose-responsive components that can undergo changes in conformation or show alterations in intermolecular binding capability in response to glucose stimulation has been studied for ultimate integration into closed-loop insulin delivery or “smart insulin” systems. Here, an overview of the evolution and recent progress in the development of molecular approaches for glucose-responsive insulin delivery systems, a rapidly growing subfield of precision medicine, is presented. Three central glucose-responsive moieties, including glucose oxidase, phenylboronic acid, and glucose-binding molecules are examined in detail. Future opportunities and challenges regarding translation are also discussed.
Entropy Neural Estimation for Graph Contrastive Learning
Creators: name: Ma, Yixuan
name: Zhang, Xiaolin
name: Zhang, Peng
name: Zhan, Kun
Publisher: name: arXiv
Year: 2023
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Contrastive learning on graphs aims at extracting distinguishable high-level representations of nodes. In this paper, we theoretically illustrate that the entropy of a dataset can be approximated by maximizing the lower bound of the mutual information across different views of a graph, \ie, entropy is estimated by a neural network. Based on this finding, we propose a simple yet effective subset sampling strategy to contrast pairwise representations between views of a dataset. In particular, we randomly sample nodes and edges from a given graph to build the input subset for a view. Two views are fed into a parameter-shared Siamese network to extract the high-dimensional embeddings and estimate the information entropy of the entire graph. For the learning process, we propose to optimize the network using two objectives, simultaneously. Concretely, the input of the contrastive loss function consists of positive and negative pairs. Our selection strategy of pairs is different from previous works and we present a novel strategy to enhance the representation ability of the graph encoder by selecting nodes based on cross-view similarities. We enrich the diversity of the positive and negative pairs by selecting highly similar samples and totally different data with the guidance of cross-view similarity scores, respectively. We also introduce a cross-view consistency constraint on the representations generated from the different views. This objective guarantees the learned representations are consistent across views from the perspective of the entire graph. We conduct extensive experiments on seven graph benchmarks, and the proposed approach achieves competitive performance compared to the current state-of-the-art methods. The source code will be publicly released once this paper is accepted.
description: ACM MM 2023 accepted
(101415) Mary Ann Harriet McDaniel
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(101416) Margaret Eliza Susan Jane McDaniel
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.