cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Crosstalk between obesity and MMP-9 in cardiac remodelling –a cross-sectional study in apparent treatment-resistant hypertension
Creators: name: Ritter, Alessandra Mileni Versuti
name: Faria, Ana Paula De
name: Barbaro, Natália
name: Sabbatini, Andréa Rodrigues
name: Nathália Batista Corrêa
name: Brunelli, Veridiana
name: Rivadavio Amorim
name: Modolo, Rodrigo
name: Moreno, Heitor
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Computational Biology

description: The balance between matrix metalloproteinases (MMP) and their tissue inhibitors (TIMP) plays a key role in the development of hypertension and obesity. We aimed to evaluate the levels of MMP-2 and 9 and TIMP-2 and -1 in obese and non-obese apparent treatment-resistant hypertensive subjects (aTRH) and its association with cardiac hypertrophy. This cross-sectional study enrolled 122 subjects and divided into obese aTRH (n = 67) and non-obese (n = 55) group. Clinical and biochemical data were compared between both groups, including office BP, ambulatory BP, plasma MMP-2 and 9, TIMP-2 and 1 and left ventricular mass index (LVMI). We found higher MMP-9 levels and MMP-9/TIMP-1 ratio in obese aTRH subjects but no difference in MMP-2 and TIMP-1 levels. Obesity influenced MMP-9 levels [β = 20.8 SE =8.6, p = 0.02) independently of potential confounders. In addition, we found a positive correlation between MMP-9 and anthropomorphic parameters. Finally, obese aTRH subjects with left ventricular hypertrophy (LVH) had greater MMP-9 levels compared with non-obese with LVH. Our study suggests that MMP-9 levels are influenced by obesity and may directly participate in the progressive LV remodelling process, suggesting a possible role for a higher cardiovascular risk in apparent resistant hypertensive subjects.
Investigating the influence of work‑related stress on early labour market exit: the role of health
Creators: name: Toczek, Lisa
name: Peter, Richard
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: Effort–reward imbalance
subject: Survival analysis
subject: Self-rated health
subject: Paid employment
subject: Poor health
subject: Follow-up
subject: Retirement intentions
subject: Ill health
subject: Pathways
subject: Pension
subject: DDC 610 / Medicine & health
subject: Job stress
subject: Occupational stress
subject: Workload
subject: Retirement
subject: Risk factors
subject: Mediation analysis
subject: Longitudinal studies
subject: Arbeitsplatz
subject: Stress
subject: Vorruhestand
subject: Längsschnittuntersuchung

description: Early labour market exit of large birth cohorts will put pressure on the social security systems of many European countries, especially Germany. Despite political efforts, many people retire before the statutory retirement age. A well-known predictor of retirement is health, which, in turn, is influenced by psychosocial working conditions such as work-related stress. This study examined whether work stress is associated with early labour market exit. In addition, we investigated whether health mediates this association. Survey data of the German Cohort Study on Work, Age, Health and Work Participation (lidA study) were linked to register data from the Federal Employment Agency, from which information on labour market exit was obtained (n = 3636). During a 6-year follow-up period, Cox proportional hazard models were used to investigate the influence of work-related stress and health on early labour market exit, adjusting for sex, age, education, occupational status, income and supervisor behaviour. Work-related stress was measured by effort–reward imbalance (ERI). Additionally, a mediation analysis was conducted to investigate a possible mediation of the association between ERI and early labour market exit by self-rated health. Higher work-related stress increased the likelihood of early labour market exit (HR 1.86; 95% CI 1.19–2.92). However, when including health in the Cox regression, the significant effect of work-related stress disappeared. Poor health was a risk factor for early labour market exit (HR 1.49; 95% CI 1.26–1.76) independent of all confounders. The results of the mediation analysis showed that self-rated health mediated the association between ERI and early labour market exit. The balance between effort and reward at work plays a major role in improving the self-rated health of workers. Interventions that reduce work-related stress can help to improve health and thus to maintain older employees in the German labour market.
Phase transitions in a metal–organic coordination polymer: [Zn2(C8H4O4)2(C6H12N2)] with guest molecules. Thermal effects and molecular mobility
Creators: name: Kozlova, Svetlana G.
name: Pishchur, Denis P.
name: Dybtsev, Danil N.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Inorganic Chemistry

description: Thermal effects of a series of [Zn2(C8H4O4)2(C6H12N2)] porous compound with the guest molecules located in the pores were studied using differential scanning calorimetry combined with solid-state 1H nuclear magnetic resonance spectroscopy. The intercalation of the molecules was shown to produce various thermal anomalies and phase transitions, which were characterized and analyzed.
Otevřené publikování: jak se zorientovat ve světě open access
Creators: name: Grofová, Šárka
Publisher: name: Zenodo
Year: 2020
Subjects: open access
gold open access
green open access
scholarly communication

description: Seminář Otevřené publikování: jak se zorientovat ve světě open access seznámil účastníky katedrálního semináře Katedry didaktiky fyziky na MFF s otevřeným přístupem k vědeckým informacím (open access, OA) a způsoby realizace OA skrze tzv. zelenou a zlatou cestu. Součástí semináře bylo také představení fenoménu predátorských časopisů a prezentace aktuálních možností a výhod pro autory z Univerzity Karlovy.
Excavations and a ground-based radar survey at Long Lane, Carlisle, 1990.
Creators: name: Flynn, Paul
name: McCarthy, Mike R
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 91, 31-48
description: An initial ground-based radar survey plotted five transects around the edge of the lawn revealing five basic zones to a depth of 3.9m. The ensuing excavation, along two trenches, uncovered thirteen phases of activity dating from the Roman period, through the medieval, to modern material. There are reports on `The pottery' by M R McCarthy & M L Hird (41--2), `The finds' by T G Padley (42--3) and `The Roman coin list' by D C A Shotter (44). Fifteen architectural fragments from the cathedral which had been placed in a rockery on part of the site are also discussed. There is a summary of documentary sources taken from notes provided by B C Jones, followed by a discussion of the Roman features (phases 1--5) and the post-Roman and medieval features (phases 6--13). IH
The Roman "Signal" Tower at Johnson's Plain, Cumbria,
Creators: name: Woolliscroft, David J
name: Swain, S A M
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 91, 19-30
description: Recent excavations at the site uncovered no dating evidence, although parallels suggest a Flavian date. Survey work indicated a double ring ditch surrounding the central area and this was confirmed by excavation. IH
Archaeological Survey of Structural Remains on Barbon High Fell.
Creators: name: Cherry, James
name: Cherry, Peter J
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 91, 13-18
description: The discovery of the remains of a small circular structure prompted a wider survey of this area of upland. Searching predominantly at a height of between 300 and 350 metres, the most common altitude for prehistoric settlement, a variety of remains were located. These included lime kilns, evidence for lime quarrying, a horse-shoe shaped enclosure, walling, cairns and several circular stone banks whose interpretation is proving a little problematical. There was also a large rectangular enclosure and the remains of a small circular hut. IH
Results of survey work carried out between the Shap and Askham Fells, Cumbria.
Creators: name: Turner, V E
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 91, 1-12
description: Selected areas were surveyed by fieldwalking during 1984 and 1985, as part of a Lake District National Park Survey by the Lancaster University Archaeological Unit. Somewhere in the region of 150 monuments, ranging from Bronze Age clearance cairns to relatively modern lime kilns, were recorded under sixty-five site headings. It is hoped that further fieldwork on similar areas will increase understanding of this type of upland landscape. IH
Embedding heterostructured α‐MnS/MnO nanoparticles in S‐doped carbonaceous porous framework as high‐performance anode for lithium‐ion batteries
Creators: name: Ma, Yuan
name: Ma, Yanjiao
name: Diemant, Thomas
name: Cao, Kecheng
name: Kaiser, Ute
name: Behm, R. Jürgen
name: Varzi, Alberto
name: Passerini, Stefano
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: α-MnS/MnO nanoparticles
subject: S-doped carbonaceous frameworks
subject: in situ XRD/lithium storage mechanism
subject: DDC 540 / Chemistry & allied sciences
subject: Lithium ion batteries
subject: Heterostructures
subject: Nanoparticles
subject: Lithium-Ionen-Akkumulator
subject: Heterostruktur
subject: Nanopartikel

description: Mechanistic exposé: Starting from Mn–MOF precursor, heterostructured α-MnS/MnO with S-doped carbonaceous frameworks (α-MnS/MnO/SCPF) achieves impressive electrochemical performance for Li-ion batteries due to its unique structural and compositional advantage. The lithium storage mechanism of α-MnS/MnO/SCPF is revealed by means of in situ XRD and two different metals as current collectors. In this work, the synthesis of α-MnS/MnO/S-doped C micro-rod composites via a simple sulfidation process is demonstrated, starting from a Mn-based metal-organic framework. The resulting heterostructured α-MnS/MnO nanoparticles (8±2 nm) are uniformly embedded into the S-doped carbonaceous porous framework with hierarchical micro-/meso-porosity. The combination of structural and compositional characteristics results in the promising electrochemical performance of the as-obtained composites as anode materials for lithium-ion batteries, coupled with high reversible capacity (940 mAh g−1 at 0.1 A g−1), excellent rate capability as well as long cycling lifespan at high rate of 2.0 A g−1 for 2000 cycles with the eventual capacity of ∼300 mAh g−1. Importantly, in situ X-ray diffraction studies clearly reveal mechanistic details of the lithium storage mechanism, involving multistep conversion processes upon initial lithiation.
Synthesis, characterization and antimicrobial activities of triorganotin(IV) complexes with azo-azomethine carboxylate ligands: crystal structure of a tributyltin(IV) and a trimethyltin(IV) complex
Creators: name: Keisham Surjit Singh
name: Manojit Roy
name: Subhadip Roy
name: Ghosh, Bikash
name: N. Manglembi Devi
name: Ch. Brajakishor Singh
name: Mun, Lo Kong
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Triorganotin(IV) complexes with polyaromatic azo-azomethine carboxylate ligands viz. 2-{4-hydroxy-3-[(2/4-hydroxyphenylimino)methyl]phenylazo}benzoic acids [H3L1/H3L2] were synthesized by reacting the ligands with either bis-tri-n-butyltin(IV) oxide (for 1 and 4) or trimethyltin(IV) chloride in presence of triethylamine (for 2 and 5) or triphenyltin(IV) hydroxide (for 3 and 6). The complexes were characterized by elemental analysis, UV, IR, NMR, and mass spectrometry. NMR spectroscopic studies of the compounds suggested that the complexes adopt four-coordinate tetrahedral geometry around tin in solution. Molecular structures of 1 and 2 were determined by single-crystal X-ray diffraction. Both complexes have distorted trigonal bipyramidal geometry around tin in the solid state. Compound 1 is a one-dimensional (1-D) double chain coordination polymer which can be described as two different 24- and 30-membered non-porous macrocyclic rings constructed from two tributyltin units and two ligand moieties. The structure of 2 comprises a discrete cyclic centrosymmetric dimer with two lattice water molecules per formula unit. In the dimer, two trimethyltin entities are bridged by two ligand moieties. The dimers are further interconnected with lattice water molecules by multiple O–H⋯O hydrogen bonds to form a 1-D H-bonded network. The complexes were also screened for their antimicrobial activities.
Thou shalt not lie! Exploring and testing countermeasures against faking intentions and faking in selection interviews
Creators: name: Bill, Benedikt
name: Melchers, Klaus G.
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: applicant reactions
subject: faking
subject: faking countermeasures
subject: impression management
subject: selection interviews
subject: DDC 150 / Psychology
subject: DDC 650 / Management & public relations
subject: Employee selection
subject: Interviews
subject: Body language
subject: Impression formation (Psychology)
subject: Personalauswahl
subject: Vorstellungsgespräch
subject: Eindruck
subject: Täuschung
subject: Körpersprache

description: Many applicants use faking in interviews to present themselves more favorably than they really are. There is widespread concern that this may affect interview validity. As previous research on countermeasures is sparse, we conducted an exploratory study to identify the most promising countermeasures. For technology-mediated interviews, these were warnings referring to a criterion-based content analysis and lie detection algorithms focusing on nonverbal or paraverbal cues. For face-to-face interviews, these were objective questions and a personable interviewer. We then investigated the effects of these countermeasures on faking intentions in two experimental vignette studies and on faking in another simulated interview study. However, none of the countermeasures could reduce faking intentions or faking. Additionally, in the vignette studies, warnings impaired applicant reactions.
A longitudinal study of the relations between university students’ subjective social status, social contact with university friends, and mental health and well-being.
Creators: name: Rubin, Mark
name: Evans, Olivia
name: Wilkinson, Ross
Publisher: name: figshare
Year: 2016
Subjects: subject: 170106 Health, Clinical and Counselling Psychology
subject: FOS: Psychology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Personality, Social and Criminal Psychology

description: Prior research has found that the higher one's perceived status in society, the better one's mental health and well-being. The present research used a longitudinal design to investigate whether social contact with friends mediated this relation between subjective social status and mental health and well-being among first-year undergraduate students at an Australian university (Wave 1 N = 749, Wave 2 N = 314). Participants completed an online survey that included measures of subjective social status, social contact with university friends during the past week, and mental health and well-being during the past week. Multiple regression analyses found that subjective social status positively predicted amount of social contact with university friends, and that both of these variables positively predicted subsequent mental health and well-being. Furthermore, bootstrapped mediation tests found that social contact with university friends acted as a significant mediator of the relations between social status and mental health and wellbeing. These results are discussed in terms of their implications for the mental health and well-being of lower class students at university.
La duración como clave acústica de la frontera de sintagma fonológico en español
Creators: name: Casado-Mancebo, Mario
Publisher: name: Zenodo
Year: 2024

description: La duración ha sido estudiada en numerosas lenguas como clave acústica de las fronteras prosódicas (p. ej., Oller, 1973 en inglés; Byrd et al., 1997 en tamil; o Shepherd, 2008 en japonés) dentro del proceso conocido como alargamiento a final de constituyente, que se caracteriza por su correlación positiva con la magnitud de la frontera prosódica (Wightman et al., 1992). En esa línea, este trabajo explora en qué medida varía la duración en torno a la frontera de sintagma fonológico (φ) frente a la de palabra fonológica para confirmar la vigencia de esta clave acústica en español. Para ello se utiliza un conjunto de muestras de sílabas similares pertenecientes a palabras anteriores y posteriores a las dos fronteras mencionadas. Se analiza tanto la duración de las sílabas como la de las vocales, ya que estas captan de manera independiente al resto de factores los efectos de la frontera (Crystal y House, 1990). Los  resultados parecen confirmar la vigencia de la duración como clave acústica para delimitar los sintagmas fonológicos del español en producción.
Synthesis, characterization and antimicrobial activities of triorganotin(IV) complexes with azo-azomethine carboxylate ligands: Crystal structure of a tributyltin(IV) and a trimethyltin(IV) complex
Creators: name: Keisham Surjit Singh
name: Manojit Roy
name: Subhadip Roy
name: Ghosh, Bikash
name: N. Manglembi Devi
name: Ch. Brajakishor Singh
name: Mun, Lo Kong
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Triorganotin(IV) complexes with polyaromatic azo-azomethine carboxylate ligands viz. 2-{4-hydroxy-3-[(2/4-hydroxyphenylimino)methyl]phenylazo}benzoic acids [H3L1/H3L2] were synthesized by reacting the ligands with either bis-tri-n-butyltin(IV) oxide (1 and 4) or trimethyltin(IV) chloride (2 and 5) or triphenyltin(IV) hydroxide in the presence of triethylamine (3 and 6). The complexes were characterized by elemental analysis, UV, IR, NMR and mass spectrometry. NMR spectroscopic studies of the compounds suggested that the complexes adopt four-coordinate tetrahedral geometry around tin in solution. Molecular structures of 1 and 2 were determined by single crystal X-ray diffraction. Both complexes have distorted trigonal bipyramidal geometry around tin in the solid state. Compound 1 is a one-dimensional (1D) double chain coordination polymer which can be described as two different 24- and 30-membered non-porous macrocyclic rings constructed from two tributyltin units and two ligand moieties. The structure of 2 comprises a discrete cyclic centrosymmetric dimer with two lattice water molecules per formula unit. In the dimer, two trimethyltin entities are bridged by two ligand moieties. The dimers are further interconnected with lattice water molecules by multiple O–H∙∙∙O hydrogen bonds to form a 1D H-bonded network. The complexes were screened for their antimicrobial activities.
Baseline clinical characteristics and disease burden in patients with paroxysmal nocturnal hemoglobinuria (PNH): updated analysis from the International PNH Registry
Creators: name: Schrezenmeier, Hubert
name: Röth, Alexander
name: Araten, David J.
name: Kanakura, Yuzuru
name: Larratt, Loree
name: Shammo, Jamile M.
name: Wilson, Amanda
name: Shayan, Gilda
name: Maciejewski, Jaroslaw P.
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Paroxysmal nocturnal hemoglobinuria
subject: Registries
subject: Health-related quality of life
subject: Eculizumab
subject: Thrombosis
subject: Bone marrow failure
subject: NATURAL-HISTORY
subject: UNITED-STATES
subject: POPULATION
subject: MANAGEMENT
subject: DIAGNOSIS
subject: HEMOLYSIS
subject: SYMPTOMS
subject: FATIGUE
subject: DDC 610 / Medicine & health

description: Abstract The International Paroxysmal Nocturnal Hemoglobinuria (PNH) Registry (NCT01374360) was initiated to optimize patient management by collecting data regarding disease burden, progression, and clinical outcomes. Herein, we report updated baseline demographics, clinical characteristics, disease burden data, and observed trends regarding clone size in the largest cohort of Registry patients. Patients with available data as of July 2017 were stratified by glycosylphosphatidylinositol (GPI)-deficient granulocyte clone size (< 10%, ≥ 10%–< 50%, and ≥ 50%). All patients were untreated with eculizumab at baseline, defined as date of eculizumab initiation or date of Registry enrollment (if never treated with eculizumab). Outcomes assessed in the current analysis included proportions of patients with high disease activity (HDA), history of major adverse vascular events (MAVEs; including thrombotic events [TEs]), bone marrow failure (BMF), red blood cell (RBC) transfusions, and PNH-related symptoms. A total of 4439 patients were included, of whom 2701 (60.8%) had available GPI-deficient granulocyte clone size data. Among these, median clone size was 31.8% (1002 had < 10%; 526 had ≥ 10%–< 50%; 1173 had ≥ 50%). There were high proportions of patients with HDA (51.6%), history of MAVEs (18.8%), BMF (62.6%), RBC transfusion (61.3%), and impaired renal function (42.8%). All measures except RBC transfusion history significantly correlated with GPI-deficient granulocyte clone size. A large proportion of patients with GPI-deficient granulocyte clone size < 10% had hemolysis (9.7%), MAVEs (10.2%), HDA (9.1%), and/or PNH-related symptoms. Although larger GPI-deficient granulocyte clone sizes were associated with higher disease burden, a substantial proportion of patients with smaller clone sizes had history of MAVEs/TEs.
How well do Humans Capture the Sounds of Speech in Writing?
Creators: name: Styles, Suzy
name: Turoman, Nora
Publisher: name: figshare
Year: 2016
Subjects: subject: 179999 Psychology and Cognitive Sciences not elsewhere classified
subject: FOS: Psychology

description: Turoman N & Styles SJ. (2016). How well do humans capture the sounds of speech in writing? In Lindborg PM & Styles SJ (Eds.), ICMA Array, vol 2016, Special Issue: Proceedings of Si15, Singapore, August 2015, pp 43–44.

Abstract. A large body of research on connections between sensory modalities has shown that deep connections exist between sound and vision, such that people have a tendency to associate certain sounds with certain visual properties, including line-drawn shapes. While recognising the role of written language in audio-visual associations, previous research has largely considered written language a potential source of bias rather than a means of gaining deeper insights into underlying audio-visual associations. We looked to ancient and unfamiliar writing systems spanning recorded human history, to explore whether humans have tried to encode certain characteristics of speech sounds in the letters they created to represent them. Our findings have revealed that modern humans can correctly identify unfamiliar letters at levels higher than would be obtained by chance, and that scripts which encode a particular sound with a particular set of visual characteristics tend to have more correct guesses. This suggests that humans share certain correspondences between sound and sight, which transcend both geographical space and historical time. The present multisensory demonstration aims to provide an interactive experience of the powerful connection between sounds and written letters through a series of activities integrating vision, audition, touch and imagination.
HadISDH.marine Update Document version 1.6.0.2023f
Creators: name: Willett, Kate
Publisher: name: Zenodo
Year: 2024

description: Update notes for HadISDH.marine.1.6.0.2023f compared to the previous version. This describes any major changes, bug fixes and minor changes, and minor bug fixes and historical updates. It includes their justification and any notable impacts. 

Note that this version has a related dataset on the CEDA archive https://catalogue.ceda.ac.uk/uuid/2fdc37a517b54376ba19d5c7432457d5.
Neurocognitive functioning and health-related quality of life in adult medulloblastoma patients: long-term outcomes of the NOA-07 study
Creators: name: Dirven, Linda
name: Luerding, Ralf
name: Beier, Dagmar
name: Bumes, Elisabeth
name: Reinert, Christiane
name: Seidel, Clemens
name: Bonsanto, Matteo Mario
name: Bremer, Michael
name: Rieken, Stefan
name: Combs, Stephanie E.
name: Herrlinger, Ulrich
name: Seliger, Corinna
name: Kuntze, Holger
name: Mayer-Steinacker, Regine
name: Dieing, Annette
name: Bartels, Claudius
name: Schnell, Oliver
name: Weyerbrock, Astrid
name: Seidel, Sabine
name: Grauer, Oliver
name: Nadji-Ohl, Minou
name: Paulsen, Frank
name: Weller, Michael
name: Wick, Wolfgang
name: Hau, Peter
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Brain tumor
subject: Medulloblastoma
subject: Cognition
subject: Quality of life
subject: Patient-reported outcome
subject: Toxicity
subject: LOW-GRADE GLIOMAS
subject: PHASE-III
subject: PEDIATRIC MEDULLOBLASTOMA
subject: RADIOTHERAPY
subject: IMPACT
subject: QUESTIONNAIRE
subject: CHEMOTHERAPY
subject: BEVACIZUMAB
subject: VALIDATION
subject: SURVIVORS
subject: DDC 610 / Medicine & health

description: Abstract Background Combined radiochemotherapy followed by maintenance chemotherapy with cisplatin, lomustine and vincristine within the NOA-07 study resulted in considerable short-term toxicity in adult medulloblastoma patients. Here we investigated the long-term impact of this treatment, focusing on neurocognitive functioning and health-related quality of life (HRQoL). Methods Neurocognitive functioning and HRQoL scores over time were determined, and differences between the post-treatment and follow-up assessments were calculated up to 18 months for neurocognition and 60 months for HRQoL. Results 28/30 patients were analyzed. The three preselected HRQoL scales (role, social and cognitive functioning) showed improved scores, to a clinically relevant extent (≥ 10 points), compared to post-treatment levels up to 30 months, but decreased afterwards. Z-scores for verbal working memory were worse during follow-up compared to post-treatment scores and remained impaired during 18 months follow-up (i.e. z-score below − 1 standard deviation). Attention was impaired post-treatment, and remained impaired to a clinically relevant extent during follow-up. Coordination/processing speed and lexical verbal fluency improved compared to post-treatment scores, and remained within the normal range thereafter. Other tests of verbal fluency were stable over time, with z-scores within the normal range. Conclusions This long-term follow-up study showed that the NOA-07 treatment regimen was not associated with a deterioration in HRQoL in the post-treatment period. Verbal working memory deteriorated, while other neurocognitive domains did not seem to be impacted negatively by the treatment.
Exploring adolescents’ physical activity and physical health in a secure psychiatric hospital
Creators: name: Anthony, Justine
Publisher: name: Loughborough University
Year: 2022
Subjects: subject: 119999 Medical and Health Sciences not elsewhere classified
subject: FOS: Other medical sciences

description: Research has indicated that adolescents in secure psychiatric care engage in significantly less physical activity (PA) and more sedentary behaviour (SB) than their peers. These behavioural factors play a significant contribution to the poor physical health, and subsequent premature mortality reported by populations with severe mental illness (SMI).Despite a growing body of research exploring PA promotion for adults with SMI, adolescents with SMI receive significantly less attention in the research literature. However, they present a group vulnerable group to the poor physical health consequences of SMI which may extend into adulthood. Driven by the lack of literature within this population, this PhD aimed to understand the physical health risks for adolescents in secure care, in addition to exploring the role of PA and a reduction in SB, both in improving the physical health of adolescents in secure care, but also contributing to their wider mental and physical wellbeing.To address these research aims; four empirical studies were developed. Firstly, a scoping review explored the literature on PA for adolescents with SMI. Secondly, to understand factors underlying PA provision in secure care, interviews with physical health practitioners, clinical staff and patients explored the barriers, facilitators, and perceived benefits of PA whilst in secure care. Findings supported that of study 1 but highlighted that for PA promotion and physical health support to become embedded within the environment, collaboration and support is needed from a wider network of staff members. Next, to understand the physical health implications of secure care, a longitudinal analysis explored weight change from admission to discharge for adolescents in secure care. Findings indicated that adolescents do gain weight in secure care, with individual differences contributing to varying BMI trajectories. Finally, to explore the wider benefits of a reduction in SB we analysed data exploring the association between grounds leave during a period of national lockdown and incidents of self-harm and violence. This provides an early indication that access to leave may be associated, acutely with lower reported incidents.This thesis presents an important contribution to early intervention research for adolescents in secure psychiatric care. Findings from this thesis have implications for both research and practice for both PA promotion and physical health considerations for adolescents in secure psychiatric care.
Volcanological study of the middle Miocene Okiduse Volcanic Group, Woodlark Island (Muyuw), eastern Papua
Creators: name: I. D. Lindley
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Woodlark Island (Muyuw) is located in a tectonically complex region, one of the few places on Earth where continental breakup is occurring ahead of seafloor spreading. Rifting commenced in the late Miocene (8.8–6 Ma) and is associated with the westward-propagating Woodlark Basin Spreading Centre. The island comprises approximately 850 km2 of raised Pleistocene coral reef and associated sediments with a central, moderately elevated range underlain by the middle Miocene calc-alkaline to shoshonitic Okiduse Volcanic Group (new name). It provides an exposure of upper Cenozoic geology in close proximity to the spreading centre. The Okiduse Volcanic Group is host to most of the island's historical gold and silver production and recently defined mineral resources totalling 1.75 Moz gold. This study uses facies analysis of pyroclastic deposits to develop a detailed geological map of the Okiduse Volcanic Group, with a revision and reinterpretation of the unit. Facies associations suggest that two major volcanic centres erupted synchronously during the middle Miocene (14–12 Ma), referred to as the Watou Mountain Eruptive Centre (new name) and the Uvarakoi Caldera (new name). The mafic–intermediate Watou Mountain Eruptive Centre formed during frequent small eruptions of widely varying style. Strombolian, subplinian, vulcanian and dome-related explosive eruptions occurred, alternating with extrusion of block and ash flow deposits and lava domes. Pyroclastic deposits were rapidly reworked from the steep cone, and were redeposited in a series of coalescing aprons surrounding the volcano. The felsic Uvarakoi Caldera formed during a series of violent explosive eruptions by rapid removal of magma from the underlying chamber, followed by collapse. Plinian and possibly phreatoplinian eruptions, as a result of magma–water mixing in the surface environment, resulted in widely dispersed, highly fragmented tuff deposits. The caldera was modified by widespread erosion following eruptions, resulting in fluvial, laharic and slope-wash deposits. This study highlights lithological controls (porosity and permeability) by various units within the Okiduse Volcanic Group on ore deposition.
Commodification of advanced and micro reactors: An invested civil engineer’s perspective
Creators: name: Whittaker, Andrew
Publisher: name: F1000 Research Limited
Year: 2024

description: This presentation was given as part of the American Nuclear Society Risk-informed, Performance-based Policy and Procedures Committee (RP3C) Community of Practice (CoP). For more information on the RP3C CoP, please visit https://www.ans.org/standards/rp3c/cop/.



This presentation took place on October 27, 2023.



The presentation video recording can be found online at https://youtu.be/FlLb7ZOiwVg.
NaWuReT colloquium: from PhD student to assistant professor : early career chemical engineers in academia
Creators: name: Friedland, Jens
name: Börnhorst, Marion
name: Kreitz, Bjarne
name: Moioli, Emanuele
name: Wehinger, Gregor
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Career
subject: Chemical and process engineering
subject: Early career scientists
subject: DDC 540 / Chemistry & allied sciences
subject: Assistant professor
subject: Wissenschaftlicher Assistent
subject: Karriere

description: The Nachwuchs Reaktionstechnik (NaWuReT) are early-career scientists from the ProcessNet Division Reaction Engineering. In autumn 2021, they organized an online colloquium with international early-career scientists from the chemical engineering community. Five guests were invited to give a scientific talk and provide insights into their career paths. The guests gave advice and emphasized the main challenges and opportunities during their early careers. Crucial points are networking, guidance, mentoring, as well as funding acquisition and the personal work-life balance.
Codes for calculating the growth rate of bacterial populations
Creators: name: Ye, Nan
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 310703
subject: Microbial ecology

description: Plate readers can measure the growth curves of many microbial strains in a high-throughput fashion.The hundreds of absorbance readings collected simultaneously for hundreds of samples create technical hurdles for data analysis. Growthcurver summarizes the growth characteristics of microbial growth curve experiments conducted in a plate reader. The data are fitted to a standard form of the logistic equation, and the parameters have clear interpretations on population-level characteristics, like doubling time, carrying capacity, and growth rate. Growthcurver is an easy-to-use R package available for installation from the Comprehensive R Archive Network (CRAN). The source code is available under the GNU General Public License and can be obtained from Github (Sprouffske K, Growthcurver sourcecode, 2016).
Towards a better understanding on mitigating algorithm aversion in forecasting : an experimental study
Creators: name: Jung, Markus
name: Seiter, Mischa
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Algorithm aversion
subject: Experimental study
subject: DDC 150 / Psychology
subject: Forecasting
subject: Time pressure
subject: Prognose
subject: Zeitdruck

description: Forecasts serve as the basis for a wide range of managerial decisions. With the potential of new data sources and new techniques for data analysis, human forecasters are increasingly interacting with algorithms. Although algorithms can show better forecasting performance than humans, forecasters do not always accept these algorithms and instead show aversion to them. Algorithm aversion has become a widely known phenomenon. Drawing on the seminal study of Dietvorst et al. (J Exp Psychol Gen 144(1):114–126, 2015), we extend the evidence on algorithm aversion by introducing three environmental variables from the management accounting literature. We argue that time pressure, “do your best” goals, and forecasters’ data input decision rights on the algorithms input mitigate algorithm aversion. To test our hypotheses, we conducted an experimental study with 1,840 participants overall. We found support for our hypothesis that time pressure mitigates algorithm aversion. We found evidence that the mitigation effect is based on forecasters’ loss of confidence in their own forecast when they are under time pressure. We found no support for our hypothesis on “do your best” goals or forecasters’ data input decision rights.
Acute stress modulates the outcome of traumatic brain injury‐associated gene expression and behavioral responses
Creators: name: Reiners, Johanna Christina
name: Leopold, Laura
name: Hallebach, Vera
name: Sinske, Daniela
name: Meier, Philip
name: Amoroso, Mattia
name: Langgartner, Dominik
name: Reber, Stefan O.
name: Knöll, Bernd
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: acute stress
subject: ATF3
subject: HPA axis
subject: immediate early gene
subject: traumatic brain injury
subject: DDC 150 / Psychology

description: Psychological stress and traumatic brain injury (TBI) result in long-lasting emotional and behavioral impairments in patients. So far, the interaction of psychological stress with TBI not only in the brain but also in peripheral organs is poorly understood. Herein, the impact of acute stress (AS) occurring immediately before TBI is investigated. For this, a mouse model of restraint stress and TBI was employed, and their influence on behavior and gene expression in brain regions, the hypothalamic–pituitary–adrenal (HPA) axis, and peripheral organs was analyzed. Results demonstrate that, compared to single AS or TBI exposure, mice treated with AS prior to TBI showed sex-specific alterations in body weight, memory function, and locomotion. The induction of immediate early genes (IEGs, e.g., c-Fos) by TBI was modulated by previous AS in several brain regions. Furthermore, IEG upregulation along the HPA axis (e.g., pituitary, adrenal glands) and other peripheral organs (e.g., heart) was modulated by AS–TBI interaction. Proteomics of plasma samples revealed proteins potentially mediating this interaction. Finally, the deletion of Atf3 diminished the TBI-induced induction of IEGs in peripheral organs but left them largely unaltered in the brain. In summary, AS immediately before brain injury affects the brain and, to a strong degree, also responses in peripheral organs.
2016 ACR: SLEEPS poster
Creators: name: Kim, Alfred
name: Chu, Philip
name: Hinze, Alicia
name: Sen, Deepali
name: Yo-El Ju
name: Eisen, Seth
Publisher: name: figshare
Year: 2016
Subjects: subject: 110703 Autoimmunity
subject: FOS: Clinical medicine
subject: 111706 Epidemiology
subject: FOS: Health sciences
subject: 110322 Rheumatology and Arthritis

description: 2016 ACR poster by Chu et al. describe the relationship between sleep quality and systemic lupus erythematosus disease activity.
2016 ACR: B cell metabolism
Creators: name: Kim, Alfred
name: Cheung, Matthew
name: Doujiao Wu
name: Baer, John
name: Clarke, Julia
name: Dongyue Huang
name: Schilling, Joel
Publisher: name: figshare
Year: 2016
Subjects: subject: 60804 Animal Immunology
subject: FOS: Biological sciences
subject: 60104 Cell Metabolism
subject: Immunology
subject: FOS: Clinical medicine

description: 2016 ACR poster by Cheung et al describing the immunometabolism of CpG-stimulated mouse B cells.
VH-TDMA: A description and verification of an instrument to measure aerosol particle hygroscopicity and volatility
Creators: name: Hakala, Jani
name: Mikkilä, Jyri
name: Hong, Juan
name: Ehn, Mikael
name: Petäjä, Tuukka
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: The aim of this study was to provide a description and characterize the performance of a volatility hygroscopicity tandem differential mobility analyzer (VH-TDMA) by calibration measurements. In our investigations, we used the two calibration standards most often used by the TDMA community: ammonium sulfate ((NH4)2SO4) and sodium chloride (NaCl) particles. The hygroscopic growth factors, volatility factors, and the hygroscopic growth factors of the nonvolatile particle core were measured in different relative humidity and thermal denuder temperature conditions. The measured hygroscopic growth and deliquescence relative humidities for ammonium sulfate and sodium chloride particles are in line with theory and results from previous measurements, as are the measurements for volatility and hygroscopicity of the particle core. We summarize the measurement campaigns, where the VH-TDMA has been deployed, and show the instrument is capable of measuring high quality data of atmospheric particle properties in various environments, in the laboratory and in the field. Copyright © 2017 American Association for Aerosol Research
Cognitive control of Asphalt Drum [CAC1]
Creators: name: Gómez, Daniel
name: De Diego, Mireya
Publisher: name: Zenodo
Year: 2022
Subjects: Apshalt
Cognitive control
Automation
Process Industry
Rotary Dryer Drum
MPC
System Identification Model
R&D
Process Control
industry 4.0
Innovation
H2020

description: The asphalt production process begins when the stockpiled aggregates in the cold feeders are metered and conveyed to a dryer drum where they are heated to a specific temperature. The control objectives are to obtain a dry product at an optimum temperature for the next process and fumes (combustion gases) at the possible lowest temperature, on one hand not to damage the bag filter and on the other to minimize energy consumption, thus increasing the efficiency of the drying process.
description: https://www.capri-project.com
Repeatability Study of Replicate Crash Tests: A Signal Analysis Approach
Creators: name: Seppi, Jeremy
name: Toczyski, Jacek
name: Crandall, Jeff R
name: Kerrigan, Jason
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: Objective: To provide an objective basis on which to evaluate the repeatability of vehicle crash test methods, a recently developed signal analysis method was used to evaluate correlation of sensor time history data between replicate vehicle crash tests. The goal of this study was to evaluate the repeatability of rollover crash tests performed with the Dynamic Rollover Test System (DRoTS) relative to other vehicle crash test methods. Methods: Test data from DRoTS tests, Deceleration Rollover Sled (DRS) tests, frontal crash tests, frontal offset crash tests, small overlap crash tests, Small Overlap Impact (SOI) crash tests, and oblique crash tests were obtained from the literature and publicly available databases (the National Highway Traffic Safety Administration vehicle database and the Insurance Institute for Highway Safety TechData) to examine crash test repeatability. Results: Signal analysis of the DRoTS tests showed that force and deformation time histories had good to excellent repeatability, while vehicle kinematics showed only fair repeatability due to the vehicle mounting method for one pair of tests and slightly dissimilar mass properties (2.2%) in a second pair of tests. Relative to the DRS, the DRoTS tests showed very similar or higher levels of repeatability in nearly all vehicle kinematic data signals with the exception of global X’ (road direction of travel) velocity and displacement due to the functionality of the DRoTS fixture. Based on the average overall scoring metric of the dominant acceleration, DRoTS was found to be as repeatable as all other crash tests analyzed. Vertical force measures showed good repeatability and were on par with frontal crash barrier forces. Dynamic deformation measures showed good to excellent repeatability as opposed to poor repeatability seen in SOI and oblique deformation measures. Conclusions: Using the signal analysis method as outlined in this paper, the DRoTS was shown to have the same or better repeatability of crash test methods used in government regulatory and consumer evaluation test protocols.
Simple synthesis of (E) and (Z)-2-(arylmethylidene)-N-phenyl succinimides via Wittig olefination by using PS-TPP resin
Creators: name: Bayat, Mohammad
name: Seyedeh Razieh Hosseini
name: Elnaz Asmari
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: PS-Triphenylphosphine resin has been used in the Wittig reaction to prepare (E)- and (Z)-2-(arylmethylidene)-N-phenylsuccinimides. PS-TP phosphoranylidene-N-phenylsuccinicimide has been obtained from PS-TPP and N-phenylmaleimide. The Wittig reaction of stabilized PS-TPP ylide with an aromatic aldehyde produced the (E)-alkene as the major product, isolated in high yields by simple filtration of PS-resin, from the reaction mixture. The better stabilized PS-TPP succinic anhydride does not react in the same conditions.