cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: A broth of ballots and falsehoods
title: a study of information disorder in the 2023 Nigerian presidential elections
titleType: Subtitle
Creators: name: Ibrahim, Abubakar Adam
Publisher: name: University of Iowa
Year: 2023
Subjects: subject: Disinformation
subject: Fake news Malinformation misinformation
subject: Information disorder
subject: Nigerian elections politics
subject: politics
subject: Press statement
subject: misinformation
subject: malinformation
subject: debunking
subject: counter-disinformation
subject: declarative
subject: journalistic
subject: public abstract
subject: Political Science
subject: FOS: Political science

description: This thesis studies the operationalization of information disorder and its various typologies in the 2023 Nigerian Presidential elections. Through the lens of critical discourse analysis (CDA), this study analyses press statements from the four major presidential candidates and their media teams in the elections to understand how they engage with, counter and otherwise weaponize information disorder to advance their political objective with emphasis on how the global information disorder has been localized to suit the socio-political peculiarities of a specific third world democracy.
description: The study finds that six typologies of the phenomena, including disinformation, malinformation and misinformation are present in a significant number of the collected samples and identifies the journalistic and declarative types of statements issued by the various campaigns and in what context the identified typologies and strategies are employed.
description:
title: The global cardiovascular magnetic resonance registry (GCMR) of the society for cardiovascular magnetic resonance (SCMR)
title: its goals, rationale, data infrastructure, and current developments
titleType: Subtitle
Creators: name: Kwong, Raymond Y.
name: Petersen, Steffen E.
name: Schulz-Menger, Jeanette
name: Arai, Andrew E.
name: Bingham, Scott E.
name: Chen, Yucheng
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Registry
subject: Cardiovascular magnetic resonance
subject: Imaging
subject: Patient management
subject: Therapeutic implications
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background With multifaceted imaging capabilities, cardiovascular magnetic resonance (CMR) is playing a progressively increasing role in the management of various cardiac conditions. A global registry that harmonizes data from international centers, with participation policies that aim to be open and inclusive of all CMR programs, can support future evidence-based growth in CMR. Methods The Global CMR Registry (GCMR) was established in 2013 under the auspices of the Society for Cardiovascular Magnetic Resonance (SCMR). The GCMR team has developed a web-based data infrastructure, data use policy and participation agreement, data-harmonizing methods, and site-training tools based on results from an international survey of CMR programs. Results At present, 17 CMR programs have established a legal agreement to participate in GCMR, amongst them 10 have contributed CMR data, totaling 62,456 studies. There is currently a predominance of CMR centers with more than 10 years of experience (65%), and the majority are located in the United States (63%). The most common clinical indications for CMR have included assessment of cardiomyopathy (21%), myocardial viability (16%), stress CMR perfusion for chest pain syndromes (16%), and evaluation of etiology of arrhythmias or planning of electrophysiological studies (15%) with assessment of cardiomyopathy representing the most rapidly growing indication in the past decade. Most CMR studies involved the use of gadolinium-based contrast media (95%). Conclusions We present the goals, mission and vision, infrastructure, preliminary results, and challenges of the GCMR. Trial registration Identification number on ClinicalTrials.gov: NCT02806193. Registered 17 June 2016.
Deadtime effects in quantification of 177Lu activity for radionuclide therapy
Creators: name: Uribe, Carlos F.
name: Esquinas, Pedro L.
name: Gonzalez, Marjorie
name: Zhao, Wei
name: Tanguay, Jesse
name: Celler, Anna
Publisher: name: Springer International Publishing
Year: 2018

description: Background: The aim of this study was to investigate the deadtime (DT) effects that are present in 177Lu images acquired after radionuclide therapy injection, assess differences in DT based on the full spectrum and the photopeak-only measurements, and design a method to correct for the deadtime losses. A Siemens SymbiaT SPECT/CT camera with a medium energy collimator was used. A 295-mL bottle was placed off-center inside a large cylinder filled with water, and 177Lu activity was sequentially added up to a maximum of 9.12 GBq. The true count rates vs. observed count rates were plotted and fitted to the DT paralyzable model. This analysis was performed using counts recorded in the full spectrum and in other energy windows. The DT correction factors were calculated using the percentage difference between the true and the observed count rates. Results: The DT values of 5.99 ± 0.02 μs, 4.60 ± 0.052 μs, and 0.19 ± 0.18 μs were obtained for the primary photons (PP) recorded in the 113- and 208-keV photopeaks and for the full spectrum, respectively. For the investigated range of count rates, the DT correction factors of up to 23% were observed for PP corresponding to the 113-keV photopeak, while for the 208-keV photopeak values of up to 20% were obtained. These values were almost three times higher than the deadtime correction factors derived from the full spectrum. Conclusions: The paralyzable model showed to be appropriate for the investigated range of counts, which were five to six times higher than those observed in the patient post-therapy imaging. Our results suggest that the deadtime corrections should be based on count losses in the scatter-corrected photopeak window and not on the deadtime determined from the full spectrum. Finally, a general procedure that can be followed to correct patient images for deadtime is presented.
Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat
Creators: name: Coan, Philip M.
name: Hummel, Oliver
name: Diaz, Ana Garcia
name: Barrier, Marjorie
name: Alfazema, Neza
name: Norsworthy, Penny J.
name: Pravenec, Michal
name: Petretto, Enrico
name: Huebner, Norbert
name: Aitman, Timothy J.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Rat
subject: Congenic
subject: Genomic
subject: Hypertension
subject: Insulin resistance
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: We previously mapped hypertension-related insulin resistance quantitative trait loci (QTLs) to rat chromosomes 4, 12 and 16 using adipocytes from F2 crosses between spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats, and subsequently identified Cd36 as the gene underlying the chromosome 4 locus. The identity of the chromosome 12 and 16 genes remains unknown. To identify whole-body phenotypes associated with the chromosome 12 and 16 linkage regions, we generated and characterised new congenic strains, with WKY donor segments introgressed onto an SHR genetic background, for the chromosome 12 and 16 linkage regions. We found a >50% increase in insulin sensitivity in both the chromosome 12 and 16 strains. Blood pressure and left ventricular mass were reduced in the two congenic strains consistent with the congenic segments harbouring SHR genes for insulin resistance, hypertension and cardiac hypertrophy. Integrated genomic analysis, using physiological and whole-genome sequence data across 42 rat strains, identified variants within the congenic regions in Upk3bl, RGD1565131 and AABR06087018.1 that were associated with blood pressure, cardiac mass and insulin sensitivity. Quantitative trait transcript analysis across 29 recombinant inbred strains showed correlation between expression of Hspb1, Zkscan5 and Pdgfrl with adipocyte volume, systolic blood pressure and cardiac mass, respectively. Comparative genome analysis showed a marked enrichment of orthologues for human GWAS-associated genes for insulin resistance within the syntenic regions of both the chromosome 12 and 16 congenic intervals. Our study defines whole-body phenotypes associated with the SHR chromosome 12 and 16 insulin-resistance QTLs, identifies candidate genes for these SHR QTLs and finds human orthologues of rat genes in these regions that associate with related human traits. Further study of these genes in the congenic strains will lead to robust identification of the underlying genes and cellular mechanisms.
Fluoroscopy use analysis of cephalomedullary nail procedures performed by orthopedic surgical residents
Creators: name: Williams, Evan
Publisher: name: University of Iowa
Year: 2022
Subjects: Fluoroscopy
Simulation
Surgical Skills
public abstract

description: Annually there are over 300,000 emergency department visits for primary hip fractures. Hip fracture repair is a common surgical procedure that many residents learn early in their careers. This type of surgery has many variations and considerations based on the fracture pattern and patient properties. Fluoroscopy use throughout a surgical procedure can have health consequences for both patient and practitioner, while an increased total duration of a procedure can lead to serious complications as well. The hypothesis for this study is that certain steps of a hip fracture repair using a cephalomedullary nail require more time and radiation than others, which could be used as a focus for training and improvement. A second hypothesis is that certain behaviors in tool movement could be measured in these large steps of the procedure that could differentiate between junior and senior resident groups. In this study, the hypotheses were assessed both in the OR and a simulator environment.
description: The OR studies were based on forty sets of fluoroscopic images collected during surgeries by 18 different junior residents. Of the nine subtasks in a cephalomedullary nail procedure, the first wire navigation task required the highest average images and had the highest average duration, 64.1 images and 14.6 minutes, respectively. The images accounted for nearly a quarter of all the fluoroscopic images. In the simulated wire navigation task, senior residents placed their entry point 1.77 mm closer to a target than junior residents (p = 0.045). The study also analyzed the swept area, or the area described by the surgical wire moving between sequential imaged positions. The swept area analysis found no significant difference between the size or number of corrections, or larger average corrections than the other, but that the two factors follow a linear trend, regardless of experience. A similar analysis of the images from the OR showed the junior and senior groups using similar average swept area sizes, 1016.8 and 1073.4 mm2, respectively. However, the junior group had a much higher variance than the senior group. From the results it is inferred that residents who make large corrective movements more frequently will require more fluoroscopic images to achieve their desired entry point, which impacts all subsequent steps of the procedure.
title: Supervisors' perspective on medical thesis projects and dropout rates
title: survey among thesis supervisors at a large German university hospital
titleType: Subtitle
Creators: name: Can, Elif
name: Richter, Felicitas
name: Valchanova, Ralitsa
name: Dewey, Marc
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Objectives: To identify underlying causes for failure of medical thesis projects and the constantly high drop-out rate in Germany from the supervisors' perspective and to compare the results with the students' perspective. Setting: Cross-sectional survey. Online questionnaire for survey of medical thesis supervisors among the staff of Charité—Universitätsmedizin Berlin, Germany. Published, earlier longitudinal survey among students for comparison. Participants: 1069 thesis supervisors participated. Data extraction and synthesis: Data are presented using descriptive statistics, and the χ2 test served to compare the results among supervisors with the earlier data from the longitudinal survey of doctoral students. Primary and secondary outcomes: Not applicable. This survey is an observational study. Results: Of 3653 potential participants, 1069 (29.3%) supervising 3744 doctoral candidates participated in the study. Supervisors considered themselves to be highly motivated and to offer adequate supervision. On the other hand, 87% stated that they did not feel well prepared for thesis supervision. Supervisors gave lack of timeliness of doctoral students and personal differences (p=0.024 and p=0.001) as the main reasons for terminating thesis projects. Doctoral students predominantly mentioned methodological problems and difficult subjects as critical issues (p=0.001 and p<0.001). Specifically, students felt ill prepared for the statistical part of their research—49.5% stated that they never received statistical assistance, whereas 97% of supervisors claimed to help their students with statistical analysis. Conclusions: The authors found that both thesis supervisors and medical students feel ill prepared for their roles in the process of a medical dissertation. Contradictory reasons for terminating medical thesis projects based on supervisors' and students' self- assessment suggest a lack of communication and true scientific collaboration between supervisors and doctoral students as the major underlying issue that requires resolution.
Galaxy And Mass Assembly (GAMA): Testing galaxy formation models through the most massive galaxies in the Universe
Creators: name: Oliva Altamirano, Paola
name: Brough, S.
name: Lidman, C.
name: Couch, Warrick
name: Hopkins, A. M.
name: Colless, M.
name: Taylor, Edward
name: Robotham, A. S.G.
name: Gunawardhana, M. L.P.
name: Ponman, T.
name: Baldry, I.
name: Bauer, A. E.
name: Bland-Hawthorn, J.
name: Cluver, Michelle
name: Cameron, E.
name: Conselice, C. J.
name: Driver, S.
name: Edge, A. C.
name: Graham, Alister
name: van Kampen, E.
name: Lara-López, M. A.
name: Liske, J.
name: López-Sánchez, A. R.
name: Loveday, J.
name: Mahajan, S.
name: Peacock, J.
name: Phillipps, S.
name: Pimbblet, K. A.
name: Sharp, R. G.
Publisher: name: Swinburne
Year: 2024

description: We have analysed the growth of Brightest Group Galaxies and Brightest Cluster Galaxies (BGGs/BCGs) over the last 3 billion years using a large sample of 883 galaxies from the Galaxy And Mass Assembly survey. By comparing the stellar mass of BGGs and BCGs in groups and clusters of similar dynamical masses, we find no significant growth between redshift z = 0.27 and 0.09. We also examine the number of BGGs/BCGs that have line emission, finding that approximately 65 per cent of BGGs/BCGs show Hα in emission. From the galaxies where the necessary spectroscopic lines were accurately recovered (54 per cent of the sample), we find that half of this (i.e. 27 per cent of the sample) harbour ongoing star formation with rates up to 10 M⊙ yr−1, and the other half (i.e. 27 per cent of the sample) have an active nucleus (AGN) at the centre. BGGs are more likely to have ongoing star formation, while BCGs show a higher fraction of AGN activity. By examining the position of the BGGs/BCGs with respect to their host dark matter halo, we find that around 13 per cent of them do not lie at the centre of the dark matter halo. This could be an indicator of recent cluster-cluster mergers. We conclude that BGGs and BCGs acquired their stellar mass rapidly at higher redshifts as predicted by semi-analytic models, mildly slowing down at low redshifts.
A team science characterization of the national COVID cohort collaborative (N3C)
Creators: name: Graves, Alexis S.
Publisher: name: University of Iowa
Year: 2024

description: This thesis presents a general analysis of team science dynamics within the National COVID Cohort Collaborative (N3C), focusing on research behavior, project characteristics, and success factors associated with the use of its data. Utilizing constructs identified within the literature, data regarding N3C projects and members, and both exploratory and targeted analysis, the study seeks to identify trends within N3C projects and teams accounting for the impact of COVID-19. Additionally, by examining the relationship between project characteristics and success metrics, this research attempts to identify predictors of success.
description: In general, N3C teams are fairly consistent with others examined within the team science literature; more teams than individuals worked within the N3C Enclave, more males than females engaged with the initiative both as lead investigators and as general researchers, although this percentage point difference decreased over time; and evidence suggested that the COVID-19 pandemic impacted general trends and success measures. With relation to research topics, three high-level categories were associated with over 50% of N3C projects: (1) Health Care, (2) Analytical, Diagnostic and Therapeutic Techniques, and Equipment, and (3) Diseases. Finally, it is unlikely that with the currently available metadata, success measures can be predicted for N3C teams.
description: The overall goal of this study was to provide insights that can help inform the design of tools, resources, and workflows to support researchers within the N3C and similar initiatives. The insights gained can be applied to enhance understanding of team science in the context of such large-scale collaborative research projects, ultimately improving research efficiency.
Cytoskeletal reorganizations in cytotoxic T lymphocytes following conjugate formation and hyperthermia.
Creators: name: Knox, John David.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1991
Subjects: subject: Biology, Cell.

description: This thesis presents the results of my investigation of the process of cell-mediated cytotoxicity and in particular the role of the microtubules and intermediate filaments in MTOC/GA orientation. Immunofluorescence microscopy was used to determine if the orientation of the MTOC is accompanied by the posttranslational modification of tubulin. My results indicate that, if a more stable subset of microtubules is formed during the orientation of the MTOC towards the TC, it does not persist long enough for the posttranslational modification of tubulin to occur. Immunofluorescence microscopy also demonstrated that conjugation results in the formation of filamentous vimentin aggregates in CTLs similar to those induced by microtubule disassembling drugs. However, intermediate filament aggregates are not formed in all conjugated CTLs and there is no evidence to suggest that their formation is required for lytic activity. A hyperthermia treatment of 42$\sp\circ$C for 30 min results in a marked inhibition, followed by a transient recovery of cytolytic activity that peaks within 6 h. The close correlation observed between the loss and recovery of microtubule organization and the loss and recovery of cytolytic activity suggest that the initial inhibitory effect of hyperthermia on cytolytic activity is due to the disruption of MTOC-microtubule organization. The microtubules of taxol-treated cells remain associated with the centrosome, but the characteristic radial array is replaced by large bundles. This microtubule organization has no effect on centrosome organization, orientation of the MTOC, nor on cytolytic ability. The results show that the normal radial organization of microtubules is not required for the functional polarization of CTL, but suggest that this process is dependent upon centrosome organization. It is proposed that 50% of the cytolytic activity of the effector cells used in this study is due to the synthesis and secretion of a lytic protein subsequent to TC binding and that the remaining activity is occurring via a protein synthesis-independent apoptotic pathway. To what extent the recovery of cytolytic activity is dependent upon the recovery of each of the pathways could not be determined. The final results presented suggest that the long-term loss in cytolytic activity may be due to hyperthermia-induced effector cell death. (Abstract shortened by UMI.)
Governance Challenges in an Eastern Indonesian Forest Landscape
Creators: name: Riggs, Rebecca A.
name: Langston, James D.
name: Margules, Chris
name: Boedhihartono, Agni Klintuni
name: Lim, Han She
name: Sari, Dwi Amalia
name: Sururi, Yazid
name: Sayer, Jeffrey
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Integrated approaches to natural resource management are often undermined by fundamental governance weaknesses. We studied governance of a forest landscape in East Lombok, Indonesia. Forest Management Units (Kesatuan Pengelolaan Hutan or KPH) are an institutional mechanism used in Indonesia for coordinating the management of competing sectors in forest landscapes, balancing the interests of government, business, and civil society. Previous reviews of KPHs indicate they are not delivering their potential benefits due to an uncertain legal mandate and inadequate resources. We utilized participatory methods with a broad range of stakeholders in East Lombok to examine how KPHs might improve institutional arrangements to better meet forest landscape goals. We find that KPHs are primarily limited by insufficient integration with other actors in the landscape. Thus, strengthened engagement with other institutions, as well as civil society, is required. Although new governance arrangements that allow for institutional collaboration and community engagement are needed in the long term, there are steps that the East Lombok KPH can take now. Coordinating institutional commitments and engaging civil society to reconcile power asymmetries and build consensus can help promote sustainable outcomes. Our study concludes that improved multi-level, polycentric governance arrangements between government, NGOs, the private sector, and civil society are required to achieve sustainable landscapes in Lombok. The lessons from Lombok can inform forest landscape governance improvements throughout Indonesia and the tropics.
A road toll for Germany
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015
Subjects: subject: road toll
subject: car toll
subject: HGV toll
subject: lorry toll
subject: coach
subject: internalisation of external costs
subject: Transport

description: A distance-based toll for HGV, coaches and cars makes it possible to set differentiated charges for infrastructure and other costs incurred by society as a result of road traffic - for instance, environmental costs. Frequent drivers pay more than occasional drivers, resulting in positive ecological and traffic steering effects and which is why the use of this instrument in Germany should be expanded. The time-based vignette is not a meaningful solution, since it amounts to a flat rate charge for frequent road users and generates almost no environmental or traffic steering effects.
Quelle: Verlagsinformation
description: A distance-based toll for HGV, coaches and cars makes it possible to set differentiated charges for infrastructure and other costs incurred by society as a result of road traffic – for instance, environmental costs. Frequent drivers pay more than occasional drivers, resulting in positive ecological and traffic steering effects and which is why the use of this instrument in Germany should be expanded. The time-based vignette is not a meaningful solution, since it amounts to a flat rate charge for frequent road users and generates almost no environmental or traffic steering effects.
Étude d'impact hydrologique de changements d'utilisation du sol sur le bassin de la rivière Raisin par simulations historiques avec le modèle à bases physiques semi-spatialisé HYDROTEL.
Creators: name: Watelet, Anne H.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2001
Subjects: subject: Hydrology.

description: The impact of various land-use changes on the hydrology of the Raisin River in Eastern Ontario was studied using simulation with the physically based semi-distributed hydrological model HYDROTEL. First, we have simulated the impact of the real land-use change which happened on the watershed between 1964 and 1978, on daily flow and soil water content. The increasing importance of cash crop in the agricultural landscape, in particular corn, and the increase in the forested area resulted in a decrease in the variability of hydrological conditions. Second, we have simulated a series of theoretical land-use scenarios, such as a totally forested watershed, a watershed entirely covered by cash crops, and a forested watershed with wetlands, in order to discriminate between the influence of particular land uses found on the watershed in the last thirty years. Cash crop is the land use which produced the most extreme conditions of all land uses tested, with spring flood happening earlier and with more intensity and low flow being the lowest. Following the two simulation exercises, it appears that from 1964 to 1978, the increasing forested area compensated for the drying effect of cash crop on soil. Land-use parameterisation is gaining importance in global-scale models but in this watershed-scale study, the parameters which have the most effect quantitatively on flow, are the snow melt factors and snow melt thresholds associated with forested or open field environments. Bioclimatic calendars of root depth, leaf area index and albedo associated with the various land uses were secondary. On the other hand, they are important for baseflow and for fall high flows and on soil water content at the end of the summer. Regarding the studied time period, meteorological fluctuations have more important impact on hydrology at the watershed scale than do land-use changes. On the other hand, land use plays a role of tempering, dampening, climatic effects and it is necessary to take that impact into account, because it is the only one for now on which it is possible to have some control.
Zwischen Immunparalyse und Hyperinflammation: Einflussfaktoren auf die Immunfunktion perioperativ und bei kritisch kranken Patienten
Creators: name: Lachmann, Gunnar
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: immune system
subject: hyperglycemia
subject: immunosuppression
subject: ICU
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Die Immunfunktion ist für das Outcome perioperativ und von kritisch kranken Patienten entscheidend, eine Immundysfunktion stellt eine eigenständige Organdysfunktion dar. Eine postoperative Immunsuppression ist vor allem mit dem Auftreten von Infektionen und Metastasen assoziiert, während diese bei kritisch kranken Intensivpatienten häufig das Outcome der Sepsis bestimmt. Auch eine überschießende Immunreaktion im Sinne des Hyperinflammationssyndroms HLH kann zum MOV mit Erhöhung der Letalität führen. Eine positive Einflussnahme auf die Immunfunktion, d.h. sowohl die Vermeidung einer Immunsuppression als auch das Erkennen eines Hyperinflammationssyndroms mit Erhalt der Immunhomöostase ist deshalb von herausragender klinischer Relevanz. Die in dieser Habilitationsschrift zusammengefassten Studien untersuchten Einflussfaktoren und Zusammenhänge der Immunfunktion perioperativ und bei kritisch kranken Patienten auf Intensivstationen. Damit soll diese Arbeit dazu beitragen, Patienten bestmöglich zu behandeln und die fatalen Folgen zu verringern. Wir konnten zunächst anhand der durchgeführten Studien zeigen, dass die postoperative Immunkompetenz hauptsächlich durch die Zellen der angeborenen Immunfunktion wiederhergestellt wird. Weiterhin sahen wir in den Ergebnissen, dass Rauchen und Übergewicht die prä- bzw. postoperative Immunfunktion entscheidend schwächen. Intraoperativ stellte sich eine Hyperglykämie als wichtiger Faktor für die postoperative Immunsuppression heraus. Anhand einer RCT konnten wir zeigen, dass die postoperative Gabe von GM-CSF bei immunsupprimierten Patienten die postoperative Immunkompetenz wiederherstellt und die Dauer einer Infektion verringert. Im Rahmen einer Studie zum Hyperinflammationssyndrom HLH fanden wir heraus, dass dieses ebenfalls mit einer hohen Letalität assoziiert ist, jedoch in 78 % aller Fälle nicht diagnostiziert wird. Ein frühzeitiges Erkennen verbessert dabei das Überleben. Die Immunfunktion unterliegt damit Faktoren, die sich positiv beeinflussen lassen und so das Outcome der Patienten verbessern. Das betrifft neben Rauchen, Übergewicht und intraoperativer Hyperglykämie ebenfalls die Möglichkeit der Immunstimulation. Überlebensentscheidend ist vor allem auch das Erkennen eines Hyperinflammationssyndroms.
Predicting the Response to Intravenous Immunoglobulins in an Animal Model of Chronic Neuritis
Creators: name: Horste, Gerd Meyer Zu
name: Cordes, Steffen
name: Pfaff, Johannes
name: Mathys, Christian
name: Mausberg, Anne K.
name: Bendszus, Martin
name: Pham, Mirko
name: Hartung, Hans-Peter
name: Kieseier, Bernd C.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a disabling autoimmune disorder of the peripheral nervous system (PNS). Intravenous immunoglobulins (IVIg) are effective in CIDP, but the treatment response varies greatly between individual patients. Understanding this interindividual variability and predicting the response to IVIg constitute major clinical challenges in CIDP. We previously established intercellular adhesion molecule (ICAM)-1 deficient non-obese diabetic (NOD) mice as a novel animal model of CIDP. Here, we demonstrate that similar to human CIDP patients, ICAM-1 deficient NOD mice respond to IVIg treatment by clinical and histological measures. Nerve magnetic resonance imaging and histology demonstrated that IVIg ameliorates abnormalities preferentially in distal parts of the sciatic nerve branches. The IVIg treatment response also featured great heterogeneity allowing us to identify IVIg responders and non- responders. An increased production of interleukin (IL)-17 positively predicted IVIg treatment responses. In human sural nerve biopsy sections, high numbers of IL-17 producing cells were associated with younger age and shorter disease duration. Thus, our novel animal model can be utilized to identify prognostic markers of treatment responses in chronic inflammatory neuropathies and we identify IL-17 production as one potential such prognostic marker.
Energy-efficient broadcast and multicast algorithms in wireless ad hoc networks
Creators: name: Guo, Song
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Computer Science.

description: This thesis systematically explores two fundamental classes of energy-efficient broadcast/multicast problem: the BPM/MPM (Broadcast/Multicast Power Minimization) problem and the BLM/MLM (Broadcast/Multicast Lifetime Maximization) problem. For the first class of problem, we have developed a general analytical MILP (Mixed Integer Linear Programming) model for the MPM problem in an ad hoc network with adaptive antennas, and also implemented a group of polynomial-time algorithms practically to handle significantly large networks for which the MILP model may not be computationally efficient. For the second problem, we have first used theoretical analysis to derive two polynomial-time optimal algorithms for the MLM/BLM problem in the omni-directional antenna scenarios. We then study the same problem with directional antennas, and conjecture that this problem is NP-hard. Based on the same analytical model, we have developed a constraint formulation for the MLM/BLM problem in terms of MILP, and also implemented a group of polynomial-time algorithms practically. Finally, we consider the same problems in mobile ad hoc networks (MANETs) and propose several distributed algorithms. Several localized operations are presented for our distributed algorithms, in which each node requires only the knowledge of its distance to all neighboring nodes and distances between its neighboring nodes. Through extensive simulation study, we show that these distributed algorithms are very efficient both in terms of energy (power or lifetime) and operation overhead.
INTEGRATED ANALYSIS OF IMAGING AND SEROLOGICAL MARKERS FOR RISK STRATIFICATION IN ACUTE PULMONARY EMBOLISM
Creators: name: Zahra Imran, Shehryar Javed, Aimen Ziafat, Rafey Mehmood Malik, Xi Chang, Mohammad Ali, Mehdi Abbas
Publisher: name: Zenodo
Year: 2024

description: Objectives: To explore the association between pulmonary artery obstruction index and serological markers with risk stratification in acute pulmonary embolism(APE).

Methods: The computed tomography pulmonary angiography (CTPA) imaging of patients diagnosed with APE were retrospectively analyzed, and the relevant imaging parameters were measured and calculated. The serological examination results of APE patients were also collected. The relationship of parameters and risk stratification of APE was analyzed by Spearman rank correlation test. The prediction power of parameter with the highest correlation for each risk stratification of APE was tested by the receiver-operating characteristic (ROC) curve.

Results: A total of 62 consecutive patients with APE were categorized into high-risk group (20 cases, 32.26%) and low- and intermediate-risk group (42 cases, 67.74%) according to the guideline. The correlation analysis revealed that Mastora score(r=0.822,p < 0.001) and BNP(r=0.754, p<0.001) had strong correlation with risk stratification. Between the two groups, Mastora score( area under the curve 0.973,p<0. 01) and BNP( area under the curve 0. 914,

p<0. 01) had the strongest prediction power for the high-risk group, respectively.

Conclusions: Mastora score and BNP are associated with risk stratification in patients with acute pulmonary embolism.

Key Words: Acute pulmonary embolism, Computed tomography pulmonary angiography, Mastora score, BNP
Design and characterization of a variable-stiffness ankle-foot orthosis powered by twisted and coiled artificial muscles
Creators: name: McFadden, Marissa
Publisher: name: University of Iowa
Year: 2024
Subjects: AFO
ankle foot orthosis
artificial muscles
twisted and coiled artificial muscles
variable stiffness
variable-stiffness

description: An ankle foot orthosis (AFO) is an assistive device that is intended to aid in the gait of a user. There is a need for a research-grade, variable-stiffness AFO that can be used outside of a lab setting. The PowAFO proposed in this work is a variable-stiffness, lightweight active AFO that utilizes the high power to weight ratio and low input voltage requirements of twisted and coiled artificial muscles (TCAMs) to achieve this goal. The orthosis is constructed of a carbon fiber shell with a spring module imbedded at the ankle to apply tension to the TCAMs which run along the back of the lower leg and contract when a voltage is applied. The force generated and the ankle angle are measured and an L1 adaptive controller is used to control the voltage applied to TCAMs to generate the desired stiffness value. Torque tracking was conducted to prove the feasibility of this design and was determined that the device can match a desired torque at a given angle. Future work includes further testing and validation to prove the feasibility of the stiffness matching capabilities in both benchtop and human-subject experiments.
Risk assessment of dietary exposure to organophosphorus flame retardants in children by using HBM-Data
Creators: name: Kolossa-Gehring, Marike
name: Plichta, Veronika
name: Steinwider, Johann
name: Vogel, Nina
name: Weber, Till
Publisher: name: My University
Year: 2022

description: Due to their extensive usage, organophosphorus flame retardants (OPFRs) have been detected in humans and in the environment. Human are exposed to OPFRs via inhalation of indoor air, dust uptake or dietary uptake through contaminated food and drinking water. Only recently, few studies addressing dietary exposure to OPFRs were published. In this study, we used human biomonitoring (HBM) data of OPFRs to estimate how much the dietary intake may contribute to the total exposure. We estimated by reverse dosimetry, the daily intake of tris (2-chloroethyl) phosphate (TCEP), tris (1-chloro-2-propyl) phosphate (TCIPP), tris (1,3-dichloro-2-propyl) phosphate (TDCIPP) for children using HBM data from studies with sampling sites in Belgium, Denmark, France, Germany, Slovenia and Slovakia. For estimating the dietary exposure, a deterministic approach was chosen. The occurrence data of selected food categories were used from a published Belgium food basket study. Since the occurrence data were left-censored, the Lower bound (LB)-Upper bound (UB) approach was used. The estimated daily intake (EDI) calculated on the basis of urine metabolite concentrations ranged from 0.03 to 0.18 (micro)g/kg bw/d for TDCIPP, from 0.05 to 0.17 (micro)g/kg bw/d for TCIPP and from 0.02 to 0.2 (micro)g/kg bw/d for TCEP. Based on national food consumption data and occurrence data, the estimated dietary intake for TDCIPP ranged from 0.005 to 0.09 (mircro)g/kg bw/d, for TCIPP ranged from 0.037 to 0.2 (mirco)g/kg bw/d and for TCEP ranged from 0.007 to 0.018 (mirco)g/kg bw/d (summarized for all countries). The estimated dietary intake of TDCIPP contributes 11-173% to the EDI, depending on country and LB-UB scenario. The estimated dietary uptake of TCIPP was in all calculations, except in Belgium and France, above 100%. In the case of TCEP, it is assumed that the dietary intake ranges from 6 to 57%. The EDI and the estimated dietary intake contribute less than 3% to the reference dose (RfD). Therefore, the estimated exposure to OPFRs indicates a minimal health risk based on the current knowledge of available exposure, kinetic and toxicity data. We were able to show that the dietary exposure can have an impact on the general exposure based on our underlying exposure scenarios. © 2022 by the authors
Open Source Program Office Research Assets Dashboard and Archival Resource
Creators: name: Gruenpeter, Morane
Publisher: name: Zenodo
Year: 2025
Subjects: OSPO
metadata
SWHID

description: Software source code is increasingly recognized as a research output even at the highest policy level (e.g.: UNESCO recommendations, the DORA declaration and the French national plan for Open Science), but scholarly infrastructures for archival and metadata management of software products are still far from mature: unlike articles or data, software's unique complexity, dependency layers, and dynamic nature present distinct challenges for preservation, curation, attribution and discoverability.

This presentation introduces the OSPO-RADAR project, an initiative by Software Heritage designed to support Open Source Program Offices (OSPOs) in research institutions. The aim is to improve how research software is managed, archived, and showcased, working to raise the profile of research software so it’s seen as a key part of research. The talk underscores the importance of archiving, referencing, describing, and citing software to ensure reproducibility, credit, and discoverability—placing software on equal footing with articles and data in scholarly communication. It highlights the role of scholarly infrastructures, metadata standards (like SWHID, CodeMeta, and FAIR-IMPACT RSMD guidelines), and collaborative community practices in mitigating software collapse and driving cultural change across national and international levels. Finally, sharing the FAIRCORE4EOSC roadmap for software metadata curation, stressing the need for sustained support, interoperability, and global recognition of research software as a first-class research output. The presentation was delivered live at the CHAOSS Community Call on April 30th 2025.
THz photomixer with a 40nm-wide nanoelectrode gap on low-temperature grown GaAs
Creators: name: Seniutinas, G.
name: Gervinskas, G.
name: Constable, E.
name: Krotkus, A.
name: Molis, G.
name: Valušis, G.
name: Lewis, R. A.
name: Juodkazis, Saulius
name: Friend, James
name: Tan, H. Hoe
Publisher: name: Swinburne
Year: 2024

description: Abstract not reproduced here by request of the publisher. The text is available from: https://doi.org/10.1117/12.2033746
DNA methylation as a predictor of fetal alcohol spectrum disorder
Creators: name: Lussier, Alexandre A.
name: Morin, Alexander M.
name: MacIsaac, Julia L.
name: Salmon, Jenny
name: Weinberg, Joanne
name: Reynolds, James N.
name: Pavlidis, Paul
name: Chudley, Albert E.
name: Kobor, Michael S. (Geneticist)
Publisher: name: BioMed Central
Year: 2018

description: Background: Fetal alcohol spectrum disorder (FASD) is a developmental disorder that manifests through a range of cognitive, adaptive, physiological, and neurobiological deficits resulting from prenatal alcohol exposure. Although the North American prevalence is currently estimated at 2–5%, FASD has proven difficult to identify in the absence of the overt physical features characteristic of fetal alcohol syndrome. As interventions may have the greatest impact at an early age, accurate biomarkers are needed to identify children at risk for FASD. Building on our previous work identifying distinct DNA methylation patterns in children and adolescents with FASD, we have attempted to validate these associations in a different clinical cohort and to use our DNA methylation signature to develop a possible epigenetic predictor of FASD. Methods: Genome-wide DNA methylation patterns were analyzed using the Illumina HumanMethylation450 array in the buccal epithelial cells of a cohort of 48 individuals aged 3.5–18 (24 FASD cases, 24 controls). The DNA methylation predictor of FASD was built using a stochastic gradient boosting model on our previously published dataset FASD cases and controls (GSE80261). The predictor was tested on the current dataset and an independent dataset of 48 autism spectrum disorder cases and 48 controls (GSE50759). Results: We validated findings from our previous study that identified a DNA methylation signature of FASD, replicating the altered DNA methylation levels of 161/648 CpGs in this independent cohort, which may represent a robust signature of FASD in the epigenome. We also generated a predictive model of FASD using machine learning in a subset of our previously published cohort of 179 samples (83 FASD cases, 96 controls), which was tested in this novel cohort of 48 samples and resulted in a moderately accurate predictor of FASD status. Upon testing the algorithm in an independent cohort of individuals with autism spectrum disorder, we did not detect any bias towards autism, sex, age, or ethnicity. Conclusion: These findings further support the association of FASD with distinct DNA methylation patterns, while providing a possible entry point towards the development of epigenetic biomarkers of FASD.
3443903.pdf
Creators: name: Seri, Alessandro
name: Corrielli, Giacomo
name: Lago-Rivera, Dario
name: Lenhard, Andreas
name: de Riedmatten, Hugues
name: Osellame, Roberto
name: Mazzera, Margherita
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary information
Romantisme et intertextualité : les échos du romancero espagnol chez Chateaubriand, Abel Hugo et Émile Deschamps.
Creators: name: Jobin, Rachel.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2002
Subjects: subject: Literature, Romance.

description: L'attrait des romances espagnols, poèmes populaires que les romantiques croyaient remonter au Moyen Âge, s'est exercé sur des écrivains comme Chateaubriand, Abel Hugo et Émile Deschamps. Ceux-ci voyaient dans le Romancero un témoignage de la mémoire du peuple, une forme d'expression collective qui aurait contribué à la prise de conscience de l'identité nationale. Nous montrerons comment ces auteurs ont transposé l'intertexte espagnol dans leurs propres textes en nous appuyant sur la distinction opérée par Gérard Genette entre les modalités intertextuelles telles que la citation, l'allusion et le plagiat, instruments privilégiés par Chateaubriand, et les modalités hypertextuelles que sont la traduction et l'imitation, employées par Abel Hugo et Émile Deschamps. À partir de l'analyse de textes précis de chacun de ces écrivains, nous nous interrogerons sur les rapports qu'établissent les romantiques français avec le Romancero: s'agit-il d'un véritable dialogue, ou l'intertextualité n'est-elle qu'une arme de combat contre les principes du classicisme?
title: Time-differentiated target temperature management after out-of-hospital cardiac arrest
title: a multicentre, randomised, parallel-group, assessor-blinded clinical trial (the TTH48 trial): study protocol for a randomised controlled trial
titleType: Subtitle
Creators: name: Kirkegaard, Hans
name: Rasmussen, Bodil S.
name: De Haas, Inge
name: Nielsen, Jorgen Feldbaek
name: Ilkjaer, Susanne
name: Kaltoft, Anne
name: Jeppesen, Anni Norregaard
name: Grejs, Anders
name: Duez, Christophe Henri Valdemar
name: Larsen, Alf Inge
name: Pettila, Ville
name: Toome, Valdo
name: Arus, Urmet
name: Taccone, Fabio Silvio
name: Storm, Christian
name: Skrifvars, Markus B.
name: Soreide, Eldar
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: Out-of-hospital cardiac arrest
subject: Target temperature management
subject: Mild therapeutic hypothermia
subject: Prolonged target temperature management
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background The application of therapeutic hypothermia (TH) for 12 to 24 hours following out-of-hospital cardiac arrest (OHCA) has been associated with decreased mortality and improved neurological function. However, the optimal duration of cooling is not known. We aimed to investigate whether targeted temperature management (TTM) at 33 ± 1 °C for 48 hours compared to 24 hours results in a better long-term neurological outcome. Methods The TTH48 trial is an investigator-initiated pragmatic international trial in which patients resuscitated from OHCA are randomised to TTM at 33 ± 1 °C for either 24 or 48 hours. Inclusion criteria are: age older than 17 and below 80 years; presumed cardiac origin of arrest; and Glasgow Coma Score (GCS) <8, on admission. The primary outcome is neurological outcome at 6 months using the Cerebral Performance Category score (CPC) by an assessor blinded to treatment allocation and dichotomised to good (CPC 1–2) or poor (CPC 3–5) outcome. Secondary outcomes are: 6-month mortality, incidence of infection, bleeding and organ failure and CPC at hospital discharge, at day 28 and at day 90 following OHCA. Assuming that 50 % of the patients treated for 24 hours will have a poor outcome at 6 months, a study including 350 patients (175/arm) will have 80 % power (with a significance level of 5 %) to detect an absolute 15 % difference in primary outcome between treatment groups. A safety interim analysis was performed after the inclusion of 175 patients. Discussion This is the first randomised trial to investigate the effect of the duration of TTM at 33 ± 1 °C in adult OHCA patients. We anticipate that the results of this trial will add significant knowledge regarding the management of cooling procedures in OHCA patients.
3443903.pdf
Creators: name: Seri, Alessandro
name: Corrielli, Giacomo
name: Lago-Rivera, Dario
name: Lenhard, Andreas
name: de Riedmatten, Hugues
name: Osellame, Roberto
name: Mazzera, Margherita
Publisher: name: Optica Publishing Group
Year: 2018
Subjects: Uncategorized

description: Supplementary information