cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The nature of the transition mismatches with Watson–Crick architecture: the G*·T or G·T* DNA base mispair or both? A QM/QTAIM perspective for the biological problem
Creators: name: Ol’ha O. Brovarets’
name: Hovorun, Dmytro M.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Cancer
Biological Sciences
Chemistry
Earth and Environmental Sciences
Biochemistry
Biophysics

description: This study provides the first accurate investigation of the tautomerization of the biologically important guanine*·thymine (G*·T) DNA base mispair with Watson–Crick geometry, involving the enol mutagenic tautomer of the G and the keto tautomer of the T, into the G·T* mispair (∆G = .99 kcal mol−1, population = 15.8% obtained at the MP2 level of quantum-mechanical theory in the continuum with ε = 4), formed by the keto tautomer of the G and the enol mutagenic tautomer of the T base, using DFT and MP2 methods in vacuum and in the weakly polar medium (ε = 4), characteristic for the hydrophobic interfaces of specific protein–nucleic acid interactions. We were first able to show that the G*·T↔G·T* tautomerization occurs through the asynchronous concerted double proton transfer along two antiparallel O6H···O4 and N1···HN3 H-bonds and is assisted by the third N2H···O2 H-bond, that exists along the entire reaction pathway. The obtained results indicate that the G·T* base mispair is stable from the thermodynamic point of view complex, while it is dynamically unstable structure in vacuum and dynamically stable structure in the continuum with ε = 4 with lifetime of 6.4·10−12 s, that, on the one side, makes it possible to develop all six low-frequency intermolecular vibrations, but, on the other side, it is by three orders less than the time (several ns) required for the replication machinery to forcibly dissociate a base pair into the monomers during DNA replication. One of the more significant findings to emerge from this study is that the short-lived G·T* base mispair, which electronic interaction energy between the bases (−23.76 kcal mol−1) exceeds the analogical value for the G·C Watson–Crick nucleobase pair (−20.38 kcal mol−1), “escapes from the hands” of the DNA replication machinery by fast transforming into the G*·T mismatch playing an indirect role of its supplier during the DNA replication. So, exactly the G*·T mismatch was established to play the crucial role in the spontaneous point mutagenesis.
3D X-ray tomography for the hygrothermal characterization of spruce wood
Creators: name: El Hachem, C.
name: Abahri, K.
name: Bennacer, R.
Publisher: name: Academic Journal of Civil Engineering
Year: 2015

description: The bio-based material considered in this work is spruce wood. Because of its complex morphology and high heterogeneity, this material still presents lacks of knowledge, concerning microscopic geometric changes, due to the hygrothermal solicitations. These changes lead usually to a considerable evolution of the resulting thermophysical properties of the material which constrains its use. The swelling and shrinkage phenomena, observed at the macroscopic scale, are the main witnesses reflecting such change caused by the hygric transfer history within the material. Indeed, the latewood/early wood transition present in the wood structure influences substantially the macroscopic behavior of the material, which is strongly dependent on the microscopic one. To answer these questions, a robust identification procedure based on very fine analysis tool is operated. It concerns an experimental investigation based on non-destructive 3D imaging technique "X-ray tomography". This method informs about the three-dimensional microstructure and also allows locating any heterogeneity in the material. The data processing was done using qualitative and quantitative approaches (phase connection, porosity...). Then, successive scans of the same specimen solicited at different hygric states provided the detection of its corresponding water field changes. This step required the development of an original device adapted to the tomograph for imposing constant relative humidity. The obtained results allowed to underscore the swelling phenomenon observed in such materials. In addition, specimens containing a latewood/early wood discontinuity are scanned, and the effect of that discontinuity on the porosity is analyzed.
description: Academic Journal of Civil Engineering, Vol 33 No 2 (2015): Special Issue - ICBBM 2015
Measurement of the hygrothermal properties of straw-clay mixtures
Creators: name: Oudhof, N.
name: Labat, M.
name: Magniont, C.
name: Nicot, P.
Publisher: name: Academic Journal of Civil Engineering
Year: 2015

description: Straw-clay mixtures are composed of unprocessed earth mixed with water and straw. The strongest advantage of such a material relies on its low environmental footprint. However, its impact on the building energy consumption an indoor comfort still has to be determined, mainly because of the lack of experimental data. This results in a poor integration in current regulation codes and in numerical studies. This work aims to assess the basic hygrothermal properties of clay-stray samples, provided by two French companies (Ecoterre and Inventerre). Results showed that the hygroscopic properties of clay-straw equals or overtops other self-insulating materials, both conventional (autoclaved aerated concrete) and biobased (hemp concrete).
description: Academic Journal of Civil Engineering, Vol 33 No 2 (2015): Special Issue - ICBBM 2015
Cell communication using intrinsically disordered proteins: what can syndecans say?
Creators: name: Leonova, Elena I.
name: Galzitskaya, Oxana V.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Cancer
Developmental Biology
Biological Sciences
Earth and Environmental Sciences
Cell Biology
Biochemistry
Biophysics
Molecular Biology

description: Because intrinsically disordered proteins are incapable of forming unique tertiary structures in isolation, their interaction with partner structures enables them to play important roles in many different biological functions. Therefore, such proteins are usually multifunctional, and their ability to perform their major function, as well as accessory functions, depends on the characteristics of a given interaction. The present paper demonstrates, using predictions from two programs, that the transmembrane proteoglycans syndecans are natively disordered because of their diverse functions and large number of interaction partners. Syndecans perform multiple functions during development, damage repair, tumor growth, angiogenesis, and neurogenesis. By mediating the binding of a large number of extracellular ligands to their receptors, these proteoglycans trigger a cascade of reactions that subsequently regulate various cell processes: cytoskeleton formation, proliferation, differentiation, adhesion, and migration. The occurrences of 20 amino acids in syndecans 1–4 from 25 animals were compared with those in 17 animal proteomes. Gly + Ala, Thr, Glu, and Pro were observed to predominate in the syndecans, contributing to the lack of an ordered structure. In contrast, there were many fewer amino acids in syndecans that promote an ordered structure, such as Cys, Trp, Asn, and His. In addition, a region rich in Asp has been identified between two heparan sulfate-binding sites in the ectodomains, and a region rich in Lys has been identified in the conserved C1 site of the cytoplasmic domain. These particular regions play an essential role in the various functions of syndecans due to their lack of structure.
Anti-BPH lignans from Urtica triangularis subsp. pinnatifida (Hand.-Mazz.) C.J.Chen
Creators: name: Fu, Qing
name: Xiao, Dongliang
name: Jiang, Nan
name: Luosang, Dunzhu
name: Cidan, Yangji
name: Xi, Yufei
name: Yan, Hai
name: Zhang, Xinyi
name: Feng, Baomin
name: Lu, Xuan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: A new lignan named (-)-ginkgool-9-O-β-glucopyranoside (1) together with eight known lignans (2-9) were isolated from Urtica triangularis subsp. pinnatifida (Hand.-Mazz.) C.J.Chen. According to the mass spectrometry and spectroscopic analyses, the gross structure and absolute configuration of the new lignan were elucidated. The cytotoxic effects of compounds 1-9 on BPH-1 cells and the docking results on type II 5α-reductase were analysed to evaluate their anti-BPH activity. The results showed better anti-BPH activity that compound 4 displaying an IC50 of 79.75 ± 3.68 μM than finasteride presenting an IC50 of 91.8 ± 3.74 μM. Compounds 1, 2 and 5 had moderate anti-BPH activity compared with finasteride.
RDF based modeling of relative and absolute chronological data: Examples from the central african rainforest and roman periodisation
Creators: name: Dirk Seidensticker
name: Florian Thiery
name: Allard Mees
name: Clemens Schmid
Publisher: name: Squirrel Papers, via Zenodo
Year: 2018
Subjects: Linked Open Data
Chronology
Roman periodisation
Rainforest

description: Chronology in Archaeology contains many hidden assumptions. Chronological intervals resulting from data analysis are sometimes based on absolute “certain” datings (e.g. C14 or Roman emperor reign years) or derived from relative datings or combinations of these. This may even lead to circular argumentations with hidden contradictions. To produce verifiable chronological relations, a well documented data scheme containing all the relevant chronological archaeological information is required.We modeled this scheme as an RDF (Resource Description Framework) based ontology comprising Allen`s interval algebra and provided the results as Linked Open Data. This is exemplarily done by parsing CSV based datasets of two case studies, one concerning the Iron Age settlement history of the Central African rainforest, and the second focusing on a system for Roman period classification used at the RGZM in Mainz.The first case study was based on a recently finished PhD thesis and reviewed the current knowledge on the settlement history of the Central African rainforest. The available data derived from surveys and excavations between present-day Cameroon and Angola. Chronological relations between groups have been modeled within a RDF graph in order to produce a machine readable and processable semantic representation. Additionally, we used radiocarbon dates from the OpenAccess data repository Archives des datations radiocarbone d'Afrique centrale (aDRAC). For the second case study, we developed a workflow for the RGZM retrieval system “easydb” in which a wide variety of time interval descriptions is used. Apart from the historically definable Roman emperor reigning years, which can often be subdivided by the consulship years of an emperor, many descriptives such as “early Roman” or “late Roman/early Medieval” are regularly used but far from being precise. For both case studies using RDF based modeling generated a reproducible representation of the state of knowledge concerning the temporal sequences of time intervals.
A Goodness-of-Fit Test for the Functional Linear Model with Scalar Response
Creators: name: García-Portugués, Eduardo
name: Wenceslao González-Manteiga
name: Febrero-Bande, Manuel
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Cancer
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Earth and Environmental Sciences
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Neuroscience
subject: Genetics

description: This article proposes a goodness-of-fit test for the null hypothesis of a functional linear model with scalar response. The test is based on a generalization to the functional framework of a previous one, designed for the goodness-of-fit of regression models with multivariate covariates using random projections. The test statistic is easy to compute using geometrical and matrix arguments, and simple to calibrate in its distribution by a wild bootstrap on the residuals. The finite sample properties of the test are illustrated by a simulation study for several types of basis and under different alternatives. Finally, the test is applied to two datasets for checking the assumption of the functional linear model and a graphical tool is introduced. Supplementary materials are available online.
title: Ένα δεύτερο μάθημα στις πιθανότητες
Creators: name: Cheliotis, Dimitrios
Publisher: name: Kallipos, Open Academic Editions
Year: 2016
Subjects: ΜΕΤΡΑ ΠΙΘΑΝΟΤΗΤΑΣ
ΝΟΜΟΣ ΜΕΓΑΛΩΝ ΑΡΙΘΜΩΝ
ΚΕΝΤΡΙΚΟ ΟΡΙΑΚΟ ΘΕΩΡΗΜΑ
ΜΕΓΑΛΕΣ ΑΠΟΚΛΙΣΕΙΣ
ΣΥΓΚΛΙΣΗ ΤΥΧΑΙΩΝ ΜΕΤΑΒΛΗΤΩΝ
Probability Measures
Convergence Of Random Variables
Law Of Large Numbers
Central Limit Theorem
Large Deviations

description: Οι στόχοι του βιβλίου είναι δύο. Πρώτα να εκτεθεί η βασική ορολογία της μετροθεωρητικής θεωρίας πιθανοτήτων, και έπειτα να μελετηθεί η οριακή συμπεριφορά ακολουθιών τυχαίων μεταβλητών. Καλύπτονται τα δύο βασικότερα είδη σύγκλισης της θεωρίας πιθανοτήτων, η σχεδόν βέβαια και η κατά κατανομή. Παρουσιάζεται η βασική τεχνική για την απόδειξη αποτελεσμάτων για καθεμία από αυτές, και εφαρμόζεται για την απόδειξη του ισχυρού νόμου των μεγάλων αριθμών και το κεντρικό οριακό θεώρημα. Τέλος, γίνεται μια εισαγωγή στη θεωρία των μεγάλων αποκλίσεων.
Antidiabetic property of fractions and pure compounds from Andrographis paniculata
Creators: name: Bokshi, Bishwajit
name: Chen, Hui
name: Ung, Alison T.
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology

description: Chlorophyll-free fractions of Andrographis paniculata were investigated for glucose uptake and lipid reduction in 3T3-L1 adipocytes. At 25 µg/ml, the acid fraction concentration enhanced glucose uptake by 82%. Basic and neutral fractions at 100 µg/ml enhanced glucose uptake by 82% and 78%, respectively. The three fractions showed improved glucose uptake compared to the crude extract (25% uptake at 50 μg/ml). GC-MS analysis of the fractions revealed the presence of chemicals with antidiabetic activities. The neutral fraction was prioritised for pure compound isolation to provide known andrographolide (1), 14-deoxyandrographolide (2), and a novel compound, 3-epi-11,12-didehydro-14-deoxyandrographolide (5). At a concentration of 1 µM, compounds 2 and 5 are as effective as 10 mM metformin in glucose uptake. They also reduce lipid accumulations in 3T3-L1 adipocytes by decreasing the size and number of lipid droplets. The activities of fractions and compounds support the use of A. paniculata in treating type 2 diabetes.
A new treatment to reduce wood hydrophilicity
Creators: name: Charlet, K.
name: Saulnier, F.
name: Gautier, D.
name: Pouzet, M.
name: Dubois, M.
name: Béakou, A.
Publisher: name: Academic Journal of Civil Engineering
Year: 2015

description: In order to get composite materials with high mechanical properties, the quality of the interface between the fibres and the matrix has to be good enough to enable the load transfer. In the case of wood polymer composites, made of hydrophilic and polar wood particles and of a generally non-polar polymer, the lack of natural compatibility between the constituents hinders the load transfer. Aiming at decreasing the gap of polarity between wood fibres and polymer matrices, fluorination has been applied to wood. This treatment is known to be very efficient to make waterproof Kraft paper and more hydrophobic carbon fibres, without using solvent or high temperature. The first step of this study was to optimize the treatment parameters (time, temperature, atmosphere…) so as to get a high level of fluorine grafting without damaging the particle surface. Several analyses were carried out to determine them (Fourier transform infrared spectroscopy, 19F solid-state nuclear magnetic resonance spectroscopy, scanning electron microscopy…). Then, the hygroscopic and thermal behaviours of the fluorinated wood flour have been evaluated and compared to the non-treated wood flour, using for example contact angle measurements and thermogravimetric analysis. The fluorine based treatment was shown to decrease notably the capacity of the wood particles to absorb water without damaging their surfaces. Lastly, the mechanical and hygroscopic properties of the composites made with fluorinated wood and polyester matrix were determined. The results revealed that the wood fluorination strongly reduced the hydrophilicity of the composite, and largely enhanced its tensile and flexural properties. This is directly linked with the improvement of the compatibility between the treated (and thus, less hydrophilic) wood particles and the polymer matrix, as also proved by X-ray tomography.
description: Academic Journal of Civil Engineering, Vol 33 No 2 (2015): Special Issue - ICBBM 2015
title: The use of translation in English for specific academic purposes classes in Saudi Arabia
Creators: name: Alsuwayhiri, Meshari Muthyib
Publisher: name: University of Glasgow
Year: 2024

description: The use of translation in second language pedagogy has long been a topic of controversy, discussion and debate. Translation was omnipresent as a language teaching method, with its dominance well-documented in the scholarly literature concerned with foreign language teaching (Kelly, 1969). However, the end of the 19th century marked a watershed moment, which saw translation fall from grace owing to critics representing the Reform Movement, who voiced a chorus of disapproval of its excessive emphasis on the written form of language to the detriment of oral proficiency. This gave rise to a host of alternative teaching methods, e.g. the Direct Method, the Berlitz Method, and the Natural Method, prioritising the development of oral competence, which translation was thought to impede, and thus was only deemed attainable if second language teaching followed a monolingual approach. Consequently, much criticism, controversy and scepticism surrounded the use of translation, with the credo that English is best taught through English prevailing as an axiom that permeated the theoretical discourse, despite relying on assumptions rather than being evidence-based (G. Cook, 2010). Since the recent turn of century, however, a growing, revived interest in translation has been observed, in conjunction with a flurry of publications and academic research advocating a return to bi/multilingual teaching, so much so that it has been termed the translation turn (Carreres & Noriega-Sánchez, 2021).

Against this backdrop, this thesis seeks to explore the attitudes of Saudi university English for specific academic purposes (ESAP) teaching staff and students to translation, the purposes for which they use it and the factors leading to its use, in addition to investigating their actual use of translation in practice. A mixed-method approach, employing classroom observations, surveys and interviews, is employed to gain an in-depth understanding of the topic under study. The results of the inquiry provide evidence of widespread use of translation in ESAP classes, despite the teaching staff being strongly in favour of an English-only approach. This offers yet another indication of the complex relationship between what teachers believe and what they actually do repeatedly reported in the literature, in this case concerning the difference between teachers’ attitudes to the use of translation and what actually occurs in their practice. The findings further show an appreciation of the merits of translation among both teachers and students, which is primarily drawn upon when issues of students’ low proficiency arise, as well as when teaching and learning complex ESAP vocabulary and grammar.
Comparative study of hygrothermal performances of strawclay and vertically perforated clay brick buildings
Creators: name: Stéphan, E.
name: Samri, D.
name: Moujalled, B.
name: Pesteil, F.
Publisher: name: Academic Journal of Civil Engineering
Year: 2015

description: The use of bio-based materials in new buildings, such as Straw-Clay (SC), corresponds perfectly to the French goal of 10% share of renewable construction materials by 2020. SC is made up of clay soil, straw and water. However, few laboratory and in situ studies have been undertaken on SC. This paper presents a comparative experimental study of transient hygrothermal behaviour of a SC building to a traditional one with vertically perforated clay bricks (VPB). They are located close in South West of France and have same orientation. Same protocol measurement has been used for both constructions. The envelope is examined through airtightness test with infrared thermography survey. Two walls are monitored for hygrothermal performance. Moreover, RH/T sensors for indoor air have been placed in different rooms. Weather station is installed near the SC building. Data presented in this paper are related to the period between July and October 2013. Unlike SC construction which shows homogeneous surface apparent temperature, VPB building presents thermal bridges located at junctions between the intermediate floor and the walls. In situ monitoring of walls underline that VPB structure has a higher ability to dampen variation of external temperature than SC wall. However, the SC wall acts as a moisture buffer managing the humidity levels within the building and contributing to a healthier environment.
description: Academic Journal of Civil Engineering, Vol 33 No 2 (2015): Special Issue - ICBBM 2015
Environmental performance of north american wood panel manufacturing
Creators: name: Bergman, R.
name: Kaestner, D.
name: Taylor, A.
Publisher: name: Academic Journal of Civil Engineering
Year: 2015

description: Manufacturing building products such as wood panels has environmental impacts, including contributions to climate change. This paper is a compilation of four studies quantifying these impacts using the life-cycle assessment (LCA) method on five wood-based panel products made in North America during 2012. LCA is an internationally accepted and standardized method for evaluating the environmental impacts of products. Using LCA, holistic environmental impacts were calculated based on survey data from mills on emissions to air and water, solid waste, energy consumption, and resource use. The present study incorporated cradle-to-gate production of nonwood materials including additives and energy products, such as natural gas and coal, consumed at the production facilities. In addition, primary transport of wood materials to the production facilities was included. These primary data were entered in LCA modeling software on a production unit of 1 m3 of the panel to estimate manufacturing gate-to-gate lifecycle inventory (LCI) flows and major environmental impacts. The LCI flows and environmental impacts were converted to a functional unit of 1 m2 of the wood panel (i.e., final product) produced. The following products were evaluated with their stated panel thicknesses in millimeters: oriented strandboard (9.5), southeast (SE) and Pacific Northwest (PNW) softwood plywood (9.5), cellulosic fiberboard (12.7), and hardboard (3.2). Results are provided here on cumulative energy consumption and global warming impacts. Cumulative energy consumption was 74.0, 73.5 (SE), 68.7 (PNW), 76.0, and 88.3 MJ/m2, with biomass energy percentage of 50%, 50% (SE), 64% (PNW), 12%, and 47 %, respectively. Global warming impact was 1.97, 1.90 (SE), 1.23 (PNW), 3.91, and 2.47 kg CO2-equivalent/m2, respectively. The panel products evaluated here are mostly not interchangeable, thus results for the panel products should not be compared. Using woody biomass energy for panel production reduces their impact on climate change.
description: Academic Journal of Civil Engineering, Vol 33 No 2 (2015): Special Issue - ICBBM 2015
title: ELEMENTS OF PROBABILITY
title: WITH APPLICATIONS IN STATISTICS AND COMPUTER SCIENCE
titleType: AlternativeTitle
title: Στοιχεία πιθανοτήτων
title: ΜΕ ΕΦΑΡΜΟΓΕΣ ΣΤΗ ΣΤΑΤΙΣΤΙΚΗ ΚΑΙ ΤΗΝ ΠΛΗΡΟΦΟΡΙΚΗ
titleType: AlternativeTitle
Creators: name: Kontogiannis, Ioannis
name: Toumpis, Stavros
Publisher: name: Kallipos, Open Academic Editions
Year: 2016
Subjects: subject: ΠΙΘΑΝΟΤΗΤΕΣ
subject: ΣΤΑΤΙΣΤΙΚΗ
subject: ΑΝΑΛΥΣΗ ΑΛΓΟΡΙΘΜΩΝ
subject: ΜΕΤΡΟ ΠΙΘΑΝΟΤΗΤΑΣ
subject: ΠΥΚΝΟΤΗΤΑ ΠΙΘΑΝΟΤΗΤΑΣ
subject: ΠΙΘΑΝΟΚΡΑΤΙΚΑ ΜΟΝΤΕΛΑ
subject: ΚΑΤΑΝΟΜΕΣ
subject: Probability
subject: Statistics
subject: FOS: Mathematics
subject: Analysis Of Algorithms
subject: Probability Measure
subject: Probability Density
subject: Distributions
subject: Probabilistic Models

description: Το σύγγραμμα προορίζεται για χρήση στη διδασκαλία της βασικής θεωρίας πιθανοτήτων, και την ανάπτυξη κάποιων εκ των θεμελιωδών εφαρμογών τους στην στατιστική και την πληροφορική. Απευθύνεται κυρίως σε πρωτοετείς (αλλά όχι μόνο) φοιτητές, πρωτίστως σε τμήματα Πληροφορικής, Μαθηματικών και Στατιστικής, αλλά λόγω του μεγάλου εύρους της ύλης που καλύπτει, και σε τμήματα Πολυτεχνικών Σχολών.

Περιλαμβάνονται, μεταξύ άλλων, κεφάλαια με αντικείμενο τις βασικές έννοιες των ενδεχομένων και της τυχαιότητας, την αξιωματική θεμελίωση της πιθανότητας, τις κύριες κατανομές και τις συνήθεις εφαρμογές τους (με έμφαση στην πληροφορική), τις διακριτές και συνεχείς τυχαίες μεταβλητές, τον νόμο των μεγάλων αριθμών και το κεντρικό οριακό θεώρημα.

Το βιβλίο είναι ιδανικό για διδασκαλία σε τμήματα τα οποία περιλαμβάνουν μικρότερο αριθμό μαθημάτων μαθηματικού υποβάθρου, και αφιερώνουν περίπου 1 μάθημα σε Λογισμό Μίας Μεταβλητής και συναφή θέματα. Υπάρχουν δεκάδες τέτοια τμήματα στην επικράτεια.

Ο βασικός στόχος του βιβλίου είναι οι φοιτητές να κατανοήσουν την βασική διαφορά -- ως τρόπο σκέψης -- της θεωρίας πιθανοτήτων από τα άλλα μαθήματα μαθηματικών τα οποία διδάσκονται. Κατά συνέπεια, να είναι σε θέση να αντιληφθούν τις έννοιες του τυχαίου και της ποσοτικής πιθανότητας και στην αυστηρά μαθηματική τους διάσταση, αλλά και στην ορθή τους χρήση σε βασικές εφαρμογές της στατιστικής και τις πληροφορικής.
Environmental impacts of agro-sourced materials compared to traditional materials into building
Creators: name: Ferrari, J.
name: Crigny, A.
name: Dupré, B.
Publisher: name: Academic Journal of Civil Engineering
Year: 2015

description: Building sector is undergoing a revolution with the development of innovative techniques and materials which significantly improved the performance of buildings. Insulation and concrete based on agro-sourced aggregates have been developed and marketed for several years now, posing as "eco-materials" and judged with less impacts to the environment than their "conventional" counterparts. Many Life Cycle Assessments of these kind of products has been made, showing in many cases, with an equivalent functional unit, an environmental benefit for the agro-sourced materials. This raises the question of the real environmental benefits of using these innovative agro-sourced materials, not more simple comparison with conventional products, but across the full life cycle of the building. Therefore, this article proposes to model a type reference building constructed two radically different ways : one with conventional building products, that is to say materials with mineral and petrochemical base and another one with integrating the maximum agro-sourced materials currently available on the market (insulation, concrete, block, glue, etc.). The objective is to conduct a comparative study analyse and interpreting differences in results between the two models. The findings of this study show significant differences in terms of overall impact on the entire life cycle of buildings. A zoom on the "Products and Equipment" section allows to be aware of the benefits of using these kind of materials. This result suggests also imply, in the case of renovation, the use of agro-based materials is very favourable to environmental assessment as mainly based on the replacement of materials.
description: Academic Journal of Civil Engineering, Vol 33 No 2 (2015): Special Issue - ICBBM 2015
Women Entrepreneurs : Problems and Help Expected from Government
Creators: name: A. DHARMENDRAN
name: C. GOWTHAMAN
Publisher: name: Zenodo
Year: 2020

description: Thus it can be concluded that the major problems faced by the entrepreneurs are from the governmental quarters itself through the government in making all-out efforts to boost the women entrepreneurs certain problems and expectations of the entrepreneurs are common to three groups of course, There are quit a few different problems and expectations which are not common to them. Efforts may be made by the authorities to solve these problems and suitable steps taken to provide the needful as expected by the entrepreneurs.
title: Development Process of Qualified AI Applications
Creators: name: Kremer, Gerald
Publisher: name: Technische Universität Berlin
Year: 2024
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::650 Management, Öffentlichkeitsarbeit::650 Management und unterstützende Tätigkeiten
subject: AI
subject: Responsible AI
subject: Development Process
subject: AI Application
subject: KI
subject: Entwicklungsprozess
subject: KI-Anwendung

description: The following document provides a generalized development process of qualified responsible AI applications. The document contains a swimlane diagram with different phases that are passed through during development. For each phase there are also detailed views with specific tasks, objectives, possible methods, tools and standards and relevant considerations to ensure that the application complies with the principles of responsible AI. The document also contains phases for qualifying the AI application. Four quality gates are built into the development, in which the model including the data, the front end, the system and the business process are qualified.
title: Σχήματα τοπίου
title: Ο ΣΧΕΔΙΑΣΜΟΣ ΤΟΥ ΤΟΠΙΟΥ ΩΣ ΕΙΔΙΚΗ ΑΡΧΙΤΕΚΤΟΝΙΚΗ ΔΙΔΑΚΤΙΚΗ
titleType: AlternativeTitle
Creators: name: Moraitis, Konstantinos
Publisher: name: Kallipos, Open Academic Editions
Year: 2016
Subjects: subject: ΑΡΧΙΤΕΚΤΟΝΙΚΗ ΤΟΠΙΟΥ
subject: ΑΡΧΙΤΕΚΤΟΝΙΚΗ
subject: ΤΟΠΙΟ
subject: ΣΧΗΜΑΤΟΠΟΙΗΣΗ
subject: ΔΙΔΑΚΤΙΚΗ ΤΟΠΙΑΚΟΥ ΣΧΕΔΙΑΣΜΟΥ
subject: ΙΣΤΟΡΙΑ ΚΑΙ ΘΕΩΡΙΑ ΤΟΥ ΤΟΠΙΟΥ
subject: ΣΧΗΜΑΤΙΣΜΟΣ
subject: Landscape Architecture
subject: Landscape
subject: Architecture
subject: FOS: Civil engineering
subject: Schematisation
subject: Landscape Design Didactics
subject: History And Theory Of Landscape
subject: Schematismus

description: Το ενδιαφέρον για το τοπίο αποτελεί ένα από τα σημαντικότερα πολιτισμικά χαρακτηριστικά της περιόδου που διανύουμε. Όχι απλώς γιατί η περιβαλλοντική μας ευαισθησία μας προτρέπει σε μια θετικότερη σχέση με το φυσικό υπόβαθρο του τοπίου, ούτε μόνο γιατί αναγνωρίζουμε πως ο πολιτισμός μας δεν μπορεί να υπάρξει παρά μόνο σε άμεση συσχέτιση με αυτό, δηλαδή με το πολιτισμικό τοπίο. Πολύ περισσότερο η τοπιακή προσέγγιση συνιστά στην εποχή μας ένα ουσιώδες «επιστημικό» παράδειγμα, αφού θεωρητικές προσεγγίσεις, όπως τα τοπολογικά μαθηματικά επιλέγουν την εποπτεία του τοπίου ως κεντρική μεταφορά των απόψεών τους, ενώ επιπλέον η ηλεκτρονική σχεδίαση καταλήγει να συγκρίνει τα μεταβαλλόμενα μορφώματά της με τα μορφώματα του τοπίου - "landscape formations".
Εν ολίγοις, η σύγχρονη αρχιτεκτονική διδασκαλία, είτε εξαιτίας της νεότερης αειφορικής προσέγγισης, είτε εξαιτίας των νέων παραστασιακών δυνατοτήτων, υποχρεώνεται να αγκαλιάσει την τοπιακή διδασκαλία, έχοντας εντούτοις να υπερβεί τον σκόπελο του σχεδιασμού υλικοτήτων και καταστάσεων με αυξημένη ασάφεια και απροσδιοριστία, όπως για παράδειγμα τον σχεδιασμό των φυτεύσεων.
Το προτεινόμενο βοήθημα επιχειρεί να καταγράψει τη μέθοδο διδασκαλίας που εφαρμόζει ο συγγραφέας του σε προπτυχιακά και μεταπτυχιακά μαθήματα σπουδαστών αρχιτεκτονικής για περισσότερο από δεκαπέντε χρόνια, μέθοδος η οποία παρουσιάζεται εν μέρει στη διδακτορική διατριβή του με θέμα «Το τοπίο πολιτισμικός προσδιορισμός του τόπου». Σύμφωνα με τη μέθοδο αυτή σε μεγάλο τμήμα της ιστορίας του τοπιακού σχεδιασμού, τα ευμετάβολα χαρακτηριστικά, όπως η φύτευση, αντιμετωπίζονται με όρους σχηματικής αφαίρεσης, σχηματοποίησης. Αυτός είναι και ο τρόπος με τον οποίο ο αρχιτέκτονας ή ο σπουδαστής αρχιτεκτονικής μπορεί να αφομοιώσει τον τοπιακό σχεδιασμό ως τμήμα της ήδη συγκροτημένης συνθετικής παιδείας του και να αντιληφθεί τη συνάφεια του τοπιακού σχεδιασμού, της «αρχιτεκτονικής» τοπίου με την εκτεταμένη ιστορία της αρχιτεκτονικής προσομοίωσης και σύνθεσης.
A complex of ceftriaxone with Pb(II): Synthesis, characterization, and antibacterial activity study
Creators: name: Lykhin, Aleksandr O.
name: Novikova, Galina V.
name: Kuzubov, Alexander A.
name: Staloverova, Natalia A.
name: Sarmatova, Natalia I.
name: Varganov, Sergey A.
name: Krasnov, Pavel O.
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: 60506 Virology
subject: FOS: Biological sciences
subject: Cancer
subject: Biological Sciences
subject: Chemistry
subject: Geology
subject: FOS: Earth and related environmental sciences
subject: Physiology
subject: Biochemistry

description: A Pb(II) complex with ceftriaxone (H2Ceftria) antibiotic was synthesized by reaction of ceftriaxone disodium salt (hemi)heptahydrate with lead nitrate in water-ethanol medium. The complex was characterized on the basis of complexometric titration, spectrophotometric and thermogravimetric analyses, capillary electrophoresis, IR, Raman and UV-vis spectroscopies, and density functional theory calculations. Pb(II) is five-coordinate with distorted square pyramidal geometry. The coordination of Ceftria2- to Pb(II) occurs through N and O of the triazine, lactam carbonyl, carboxylate and amine groups. The antibacterial activity study showed that Klebsiella pneumonia is resistant to [Pb(Ceftria)]∙3H2O. The antibacterial activity of [Pb(Ceftria)]∙3H2O against Staphylococcus aureus is reduced compared with ceftriaxone. In contrast, the antibacterial activity of [Pb(Ceftria)]∙3H2O against Escherichia coli is 28% higher than of ceftriaxone antibiotic.
Evaluating the therapeutic potential of Indian traditional medicine against multidrug-resistant pathogens: a comprehensive approach with MALDI-TOF-MS and gc-MS analysis
Creators: name: Pombala, Sujitha
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Multidrug-resistant pathogens pose a significant and pressing global health threat. This study explores the therapeutic potential of Indian Traditional Medicine, particularly Yagya, as an innovative antimicrobial strategy rooted in the ancient Rig Veda traditions dating back to 7500 B.C. Our research uses advanced analytical techniques like GC-MS and MALDI-TOF to investigate Yagya’s antimicrobial properties against challenging Gram-positive and Gram-negative bacteria. Our study reveals proteomic insights into bacterial responses, including Glutamate Decarboxylase, EF-Tu, and Alpha-Hemolysin. Altered expression levels suggest significant impacts on bacterial survival, shedding light on the multifaceted mechanisms. By showcasing Yagya’s remarkable antimicrobial properties, it provides valuable proteomic insights into its mode of action. This study sets stage for future research to harness Indian Traditional Medicine in combatting microbial infections, especially those driven by multidrug-resistant pathogens. This research emphasises the importance of exploring alternative and complementary approaches in modern medicine to combat the global health crisis of antibiotic resistance.
Isolation and characterisation of methanol-soluble fraction of Alternanthera philoxeroides (Mart.) – evaluation of their antioxidant, α-glucosidase inhibitory and antimicrobial activity in in vitro systems
Creators: name: Abhishek Bhattacherjee
name: Tanushree Ghosh
name: Rajarshi Sil
name: Abhijit Datta
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Hematology
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Biotechnology
subject: Physiology
subject: Cell Biology
subject: Physics
subject: Engineering
subject: Biochemistry

description: Alternanthera philoxeroides (Mart.) is a tropical weed commonly known as alligator weed. It grows rapidly within a small span of time and easily available all over the world. The objective of this work was to isolate and characterise the major phenolic components present in the methanol-soluble fraction (fraction X) of A. philoxeroides leaves and to explore the biological activity (antioxidant, α-glucosidase inhibition and antimicrobial) of the fraction in in vitro system. Chromatographic (HPLC) and spectroscopic (MALDI-TOF, 1H NMR) techniques were used to purify and characterise the phenolics present in fraction X. Five major phenolics (kaempferol, ferulic acid, salicylic acid, syringic acid and chlorogenic acid) were found in fraction X. The fraction showed anti-oxidant property, dose-dependent inhibition of α-glucosidase activity and anti-microbial activity. Hence fraction X from the weed has therapeutic potential in pathophysiological condition.
Triterpenes as uncompetitive inhibitors of α-glucosidase from flowers of Punica granatum L.
Creators: name: Dine, Riham Salah El
name: Ma, Qiong
name: Kandil, Zeinab A.
name: El-Halawany, Ali M.
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: 60506 Virology
subject: FOS: Biological sciences
subject: Hematology
subject: Cancer
subject: Biological Sciences
subject: Ecology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Pharmacology
subject: Molecular Biology
subject: Engineering
subject: Biochemistry

description: The α-glucosidase and maltase inhibitory effects of Punica granatum L. flowers (PGF) were investigated. The methanol extract (PGFMe), n-hexane extract (PGFH), chloroform extract (PGFC) and the remaining water fraction (PGFW) were assayed for their α-glucosidase and maltase inhibitory effects. PGFW showed potent α-glucosidase inhibition with IC50 of 0.8 μg/mL followed by PGFMe (IC50 of 4.0 μg/mL) then PGFC (IC50 of 5.21 μg/mL) in comparison to acarbose (0.9 μM). Due to its selectivity towards α-glucosidase, PGFC was subjected to bioactivity-guided isolation of its main active constituents. Five known compounds (1–5) were identified as β-sitosterol (1), oleanolic acid (2), ursolic acid (3), p-coumaric acid (4) and apigenin (5). Ursolic and oleanolic acids showed potent α-glucosidase inhibition (IC50 of 39.0 and 35.0 μM, respectively), while they did not show significant maltase inhibition. Kinetic study using the double Lineweaver–Burk plot revealed that ursolic acid uncompetitively inhibited α-glucosidase in comparison with acarbose as a competitive inhibitor.
Selenium nanoparticles improved biochemical and physiological properties and antioxidant systems of savoury under drought stress
Creators: name: Nasiri, Yousef
name: Asadi, Mohammad
name: Zahedi, Seyed Morteza
name: Venditti, Alessandro
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: To investigate the effectiveness of selenium (Se) and Se nanoparticles (Se-NPs) in improving biochemical and physiological characteristics of savoury in drought stress conditions, a factorial experiment based on the completely randomised design with three replications was used. Results demonstrate that Se-NPs considerably enhanced several biochemical parameters, such as relative water content (RWC), antioxidant enzymes activity, and total soluble protein in drought and normal conditions. At the stress level from 100 to 40% of field capacity, a gradual decrease in chlorophyll and CARs contents was observed and under stress and normal conditions, the application of Se-NPs (10 mg L−1) led to an increase in the content of pigments. Total soluble protein, total phenolic and flavonoid contents showed significant increases in plants treated with Se-NPs under drought stress. Generally, the use of Se-NPs in drought stress conditions can be effective in improving the growth, biochemical, and physiological characteristics of savoury.
Effects of plant extracts and derivatives on cardiac K+, Nav, and Cav channels: a review
Creators: name: Seck, Insa
name: Ndoye, Samba Fama
name: Kapchoup, Michelle Vanessa Kamga
name: Nguemo, Filomain
name: Ciss, Ismaila
name: Ba, Lalla Aicha
name: Ba, Abda
name: Sokhna, Seynabou
name: Seck, Matar
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified

description: Natural products (NPs) are endless sources of compounds for fighting against several pathologies. Many dysfunctions, including cardiovascular disorders, such as cardiac arrhythmias have their modes of action regulation of the concentration of electrolytes inside and outside the cell targeting ion channels. Here, we highlight plant extracts and secondary metabolites’ effects on the treatment of related cardiac pathologies on hERG, Nav, and Cav of cardiomyocytes. The natural product’s pharmacology of expressed receptors like alpha-adrenergic receptors causes an influx of Ca2+ ions through receptor-operated Ca2+ ion channels. We also examine the NPs associated with cardiac contractions such as myocardial contractility by reducing the L-type calcium current and decreasing the intracellular calcium transient, inhibiting the K+ induced contractions, decreasing amplitude of myocyte shortening and showed negative ionotropic and chronotropic effects due to decreasing cytosolic Ca2+. We examine whether the NPs block potassium channels, particular the hERG channel and regulatory effects on Nav1.7.
Influence of cellulose pulp fiber addition on the hydration of cementitious pastes with silica fume
Creators: name: Siqueira, I. S.
name: Toledo Filho, R. D.
name: Koenders, E. A. B.
Publisher: name: Academic Journal of Civil Engineering
Year: 2015

description: The use of natural fibers in cementitious materials can provide multiple benefits on both the issue of reducing the environmental impact and the mechanical behavior, while enhancing the toughness and post-cracking resistance. However, to be able to use these materials in various areas of engineering it is necessary to better understand its behavior in the fresh, hardening and hardened state. The present study aimed at investigating the influence of cellulose fibers (eucalyptus and pine) on the hydration of cement pastes containing silica fume. For this goal, composites were produced with volumetric fiber fractions of 0, 0.25, 0.50 and 1.0%. The matrix was composed of cement, silica fume, silica sand, water and superplasticizer. The ratio of materials was 1: 1: 0.55 (cementitious blend: silica sand: water/cementitious blend). The ratio of the cement blend was: 0.65 :0.35 (cement :silica fume). Hydration was studied from tests using ultrasonic pulse velocity, adiabatic calorimetry, electrical conductivity, isothermal calorimetry. The evolution of the compressive strength with time for the mixtures under consideration was determined until the age of 180 days. From the results, it was observed that the dormant stage period was not affected by the presence of pulps, but once commenced, a retardation of the hydration reactions occured. Furthermore, an inclination in the rate of hydration during the acceleration period developed that could be associated with the kinetics and the formation of various hydration products, including pozzolanic C-S-H. Through adiabatic calorimetry tests, it was concluded that pine fibers cause a larger reduction in total heat release than eucalyptus fibers. This is due to the fact that pine fibers contain more hemicellulose, lignin and extractives than eucalyptus fibers. Finally, comparing non-destructive testing results with the compressive strength results, a reduction in the ultimate strength (after 180 days) appeared, which is in agreement with the lower formation of hydrated products indicated by the adiabatic and isothermal tests.
description: Academic Journal of Civil Engineering, Vol 33 No 2 (2015): Special Issue - ICBBM 2015
Evaluation of the Quality of Angelica sinensis by High-Performance Liquid Chromatography
Creators: name: Zhenzhong Wang
name: Shijun Shao
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology

description: Quality control and consistent quality are prerequisites to guarantee the safety and efficacy of pharmaceutical preparations and dietary supplements. In this paper, the intra- and inter-annual consistency and stability of Angelica sinensis (Oliv.) Diels, cultivated according to Good Agricultural Practices (GAP) in the main production areas of China, were evaluated by high-performance liquid chromatographic fingerprints composed of twenty-four common components. Subsequently, thirteen compounds were identified in the chromatograms using diode array detection and mass spectrometry. Z-Ligustilide, senkyunolide H, senkyunolide I, and ferulic acid were determined to evaluate the distribution of chemical components. In addition, robust principal component analysis was applied to further evaluate the samples, and four discriminatory “markers” among the common twenty-four were pinpointed by the loading plots that were used to distinguish quality differences of Angelica sinensis from different harvest years.
HPLC of anthocyanins in port wines: Determination of ageing rates
Creators: name: Bakker, Johanna
Publisher: name: VITIS - Journal of Grapevine Research
Year: 2015

description: The total and individual anthocyanin contents in several port wines ageing at different rates were determined by HPLC at regular intervals during the first 46 weeks of storage at 15 °C. The losses of anthocyanins were logarithmic with time. There were small differences in the rate of ageing of the major anthocyanins (malvidin 3-glucoside, malvidin 3-acetylglucoside and malvidin 3-p-cownarylglucoside), but no firm conclusions could be drawn after consideration of all factors involved. The rate of loss of total known anthocyanins best reflected the rate of ageing of anthocyanins in port wines. During the initial ageing in the presence of free acetaldehyde, the molar loss of anthocyanins was higher than the molar loss of acetaldehyde, indicating that both acetaldehyde condensation and direct condensation not involving acetaldehyde occurred at this stage. Increasing acetaldehyde contents increased the rate of loss of anthocyanins. Acetaldehyde was still reacting when little anthocyanins remained, indicating the formation of complex branched polymers. The percentage of colour due to polymeric material was between 23 and 30 % in the young ports, while after 46 weeks it was between 78 and 98 %; the port with the highest free acetaldehyde content showed the fastest increase in the percentage of polmeric pigment colour. The absorbance due to polymers and the st ability of its colour was dependent on the free acetaldehyde concentration.
description: VITIS - Journal of Grapevine Research, Vol. 25 No. 4 (1986): VITIS