cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Study of Initial and Final State Effects in Ultrarelativistic Heavy Ion Collisions Using Hadronic Probes
Creators: name: Purwar, Anuj Kumar
Publisher: name: Zenodo
Year: 2004
Subjects: deconfinement
nuclear modification factor
jet suppression
minimum bias
tof scintillator

description: This doctoral dissertation reports the properties of the final state of produced matter in Au+Au collisions at √sNN = 200GeV, using measurements made of the transverse momentum spectra of deuterons and anti-deuterons in the range 1.1< pT<4.3 GeV/c at mid-rapidity. It was found to be less steeply falling than the proton (and antiproton) spectra. We also probed the initial conditions by looking at the nuclear modification factor Rcp from particle production in forward and backward directions using d+Au collisions at √sNN = 200 GeV. This allowed us to distinguish between effects that could potentially be due to deconfinement, versus effects of cold nuclear matter.
Sleep Apnea Is Independently Associated With Peripheral Arterial Disease in the Hispanic Community Health Study/Study of LatinosSignificance
Creators: name: Shah, Neomi
name: Zee, Phyllis C.
name: Teng, Yanping
name: Gallo, Linda C.
name: Criqui, Michael H.
name: Wassertheil-Smoller, Sylvia
name: Yaggi, Henry K.
name: Allison, Matthew
name: Redline, Susan
name: Ramos, Alberto R.
name: Kaplan, Robert C.
name: Sotres-Alvarez, Daniela
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Sleep apnea (SA) has been linked with various forms of cardiovascular disease, but little is known about its association with peripheral artery disease (PAD) measured using the ankle- brachial index (ABI). This relationship was evaluated in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).
Conference Proceeding
Creators: name: Rawat, Ravi
Publisher: name: figshare
Year: 2022
Subjects: subject: 30499 Medicinal and Biomolecular Chemistry not elsewhere classified
subject: FOS: Chemical sciences

description: Dihydroorotate (DHODH) is an essential enzyme of de novo pyrimidine biosynthesis, catalysing the ubiquinone- mediated oxidation of dihydroorotate to orotate. DHODH is considered a druggable target. Recently, academics and industry researchers have been directing efforts in investigating DHODH inhibition to manage autoimmune diseases, cancer, malaria, and other diseases. Our group initiated this research project with the aim to study the molecular mechanism of PfDHODH inhibition using MD simulation in order to design novel inhibitors. A program named, HeroMDAnalysis was developed to assist in the analysis of MD simulation. Importantly, this GUI tool can be very helpful to biochemists, synthetic chemists, and pharmacologists involved in the area of MD simulation. Progressively, in the context of identifying novel inhibitors to target PfDHODH, various computer- aided drug design approaches were utilized. The pursuit resulted in 3 different series of imidazo-fused heterocycles namely: 1) Aminomethylated-imidazo[1,2-a]pyridines, 2) N-arylated-imidazo[2,1- b][1,3,4]thiadiazoles, and 3) 1H-benzo[d]imidazole-alkyl-acetamides. Progressively, the imidazo-fused heterocycles were synthesized using novel chemical methodologies. The advantages of methodologies used in this project includes atom economy, operational simplicity, reduced waste, and moderate to good yields. A total of 38 compounds were synthesized, and structure elucidation was carried out using advanced spectroscopic techniques including 1H and 13C NMR, ESI-MS, FT-IR, CHNS elemental analysis. Finally, the synthesized compounds were investigated for in vitro anti-malarial activities against Plasmodium falciparum 3D7 (Drug sensitive), Dd2 (Chloroquine-resistant), and INDO (Chloroquine-resistant), and anti-cancer activities against MCF-7 (human breast adenocarcinoma) and A549 (NSC lung cancer) cell lines. The present study resulted in identification of 3 compounds which have showed inhibitory potential of IC50 Pf3D7 cell line. The compounds were also active against drug resistant cell lines of Plasmodium parasite (PfDd2 and PfINDO). Further, the molecules could serve as lead for further optimization of potency and preclinical development.
The challenges of LGBTIQ+ migration to the EU in the view of the rise of far-right parties
Creators: name: Kurtanidze, Erekle
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 470211
subject: Migrant cultural studies
classificationCode: 440501
subject: Feminist and queer theory
classificationCode: 480704
subject: Migration, asylum and refugee law

description: Following the 2015 Refugee Crisis, migration studies gained projection across academic disciplines. The European Union has become a significant destination for foreign immigration. The mass influx of migrants, specifically from the MENA region, has resulted in the emergence of the far-right wing and the propagation of nationalist beliefs across Europe's political arenas, which are filled with anti-migration sentiments. There are migrants who seek international protection owing to dangers in their home countries. LGBTIQ+ migrants are forced to quit their home countries due to existing homophobia, biphobia, and transphobia in order to avoid various dangers and preserve their lives. When we look at the worldwide evaluation of the ILGA globe, we notice that seventy-eight nations still ban homosexuality, and six of them even use the death penalty (ILGA, 2022). LGBTIQ+ migrants may experience sexual assault, discrimination, and rape on their way to the EU. They lack access to queer-specific assistance, which has an impact on their physical and mental health. The rise of far-right parties in the EU has fueled anti-LGBTIQ+ attitudes due to their heteronormative beliefs. Along with anti-migration principles, populist parties promote challenging policies for queer asylum seekers because they belong to both the LGBTIQ+ and migrant populations. Concerns have been raised regarding the impact of their discriminatory initiatives on LGBT people. Far-right political groups advocate for restrictive laws that may have an affect on the well-being of LGBTQ asylum seekers. The purpose of this study is to learn how far-right political parties influence LGBTIQ+ migrants, as well as how anti-migration and anti-LGBTIQ+ campaigns affect the well-being of Queer asylum seekers in the EU. Acknowledgments I would want to convey my heartfelt appreciation to all persons and organizations that have contributed to the LGBTIQ+ migration on academic, social, cultural, and political levels. The associations and their data in order to see acts through the public eye. My gratitude goes to the LGBT institutions, human rights advocates, and other professionals whose ideas and perspectives impacted my knowledge of these interests. I would like to thank Professor Florian Trauner, the research supervisor, for his direction and effective comments during the working process. His participation has enhanced the overall quality of this study. Furthermore, I would want to dedicate the research to the LGBTIQ+ migrant population, who have fled their homes and loved people in order to save their lives and be reborn without the fears that they have endured. Completely, I hope that the research will have an influence and result in a good improvement in the well-being of gay asylum seekers in the European Union.
Reactive Flash Volatilisation of Waste Grassy Biomass for Hydrogen Production
Creators: name: ARYAL, PRAKASH
Publisher: name: Monash University
Year: 2023
Subjects: classificationCode: 401703
subject: Energy generation, conversion and storage (excl. chemical and electrical)
classificationCode: 340601
subject: Catalysis and mechanisms of reactions
classificationCode: 380105
subject: Environment and resource economics

description: This thesis investigates on Reactive Flash Volatilization (RFV) of grassy biomasses as a prospective method for efficient conversion into hydrogen by overcoming the challenges in the existing biomass gasification industry, such as tar formation and biomass supply bottleneck. This study explores utilising biomass ash as a catalyst and also investigates on re-use potential of spent catalysts. The effect of biomass structure and composition on hydrogen yield via RFV was investigated for the first time. Ultimately, the techno-enviro-economic viability of a medium-scale commercial plant was assessed, resulting cost of 3.8 AUD/kg hydrogen, which is comparable to the cost of blue hydrogen.
Effects of hormonal changes on sarcopenia in chronic kidney disease: where are we now and what can we do?
Creators: name: Gungor, Ozkan
name: Ulu, Sena
name: Hasbal, Nuri Baris
name: Anker, Stefan D.
name: Kalantar‐Zadeh, Kamyar
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Sarcopenia
subject: Chronic kidney disease
subject: Hormones
subject: Cachexia
subject: COVID-19
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Sarcopenia or muscle wasting is a progressive and generalized skeletal muscle disorder involving the accelerated loss of muscle mass and function, often associated with muscle weakness (dynapenia) and frailty. Whereas primary sarcopenia is related to ageing, secondary sarcopenia happens independent of age in the context of chronic disease states such as chronic kidney disease (CKD). Sarcopenia has become a major focus of research and public policy debate due to its impact on patient's health-related quality of life, health-care expenditure, morbidity, and mortality. The development of sarcopenia in patients with CKD is multifactorial and it may occur independently of weight loss or cachexia including under obese sarcopenia. Hormonal imbalances can facilitate the development of sarcopenia in the general population and is a common finding in CKD. Hormones that may influence the development of sarcopenia are testosterone, growth hormone, insulin, thyroid hormones, and vitamin D. Although the relationship between free testosterone level that is low in uraemic patients and sarcopenia in CKD is not well-defined, functional improvement may be seen. Unlike testosterone, it is known that vitamin D is associated with muscle strength, muscle size, and physical performance in patients with CKD. Outcomes after vitamin D replacement therapy are still controversial. The half-life of growth hormone (GH) is prolonged in patients with CKD. Besides, IGF-1 levels are normal in patients with Stage 4 CKD-a minimal reduction is seen in the end-stage renal disease. Unresponsiveness or resistance of IGF-1 and changes in the GH/IGF-1 axis are the main causes of sarcopenia in CKD. Low serum T3 level is frequent in CKD, but the net effect on sarcopenia is not well-studied. CKD patients develop insulin resistance (IR) from the earliest period even before GFR decline begins. IR reduces glucose utilization as an energy source by hepatic gluconeogenesis, decreasing muscle glucose uptake, impairing intracellular glucose metabolism. This cascade results in muscle protein breakdown. IR and sarcopenia might also be a new pathway for targeting. Ghrelin, oestrogen, cortisol, and dehydroepiandrosterone may be other players in the setting of sarcopenia. In this review, we mainly examine the effects of hormonal changes on the occurrence of sarcopenia in patients with CKD via the available data.
Real-time observation of domain fluctuations in a two-dimensional magnetic model system
Creators: name: Kronseder, Matthias
name: Meier, Thomas Norbert  G.
name: Zimmermann, Michael
name: Buchner, Martin
name: Vogel, Michael
name: Back, Christian H.
Publisher: name: Universität Regensburg
Year: 2015
Subjects: subject: 530 Physik

description: Domain patterns of perpendicularly magnetized ultra-thin ferromagnetic films are often determined by the competition of the short range but strong exchange interaction favouring ferromagnetic alignment of magnetic moments and the long range but weak antiferromagnetic dipolar interaction. Detailed phase diagrams of the resulting stripe domain patterns have been evaluated in recent years; however, the domain fluctuations in these pattern forming systems have not been studied in great detail so far. Here we show that domain fluctuations can be observed in ultra-thin two-dimensional ferromagnetic Fe/Ni/Cu(001) films with perpendicular magnetization in the stripe domain phase. Non-stroboscopic time-resolved threshold photoemission electron microscopy with high temporal resolution allows analysing the dynamic fingerprint of the topological excitations in the nematic domain phase. Furthermore, proliferation of domain ending defects in the vicinity of the spin reorientation transition is witnessed.
Additional file 7 of Enrichment of human nasopharyngeal bacteriome with bacteria from dust after short-term exposure to indoor environment: a pilot study
Creators: name: Konecna, Eva
name: Videnska, Petra
name: Buresova, Lucie
name: Urik, Milan
name: Smetanova, Sona
name: Smatana, Stanislav
name: Prokes, Roman
name: Lanickova, Barbara
name: Budinska, Eva
name: Klanova, Jana
name: Borilova Linhartova, Petra
Publisher: name: figshare
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 7. The questionnaire for study participants.
De novoCIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): A new member of the expanding family of pyrin-associated autoinflammatory diseases
Creators: name: Goldsmith, Donald
name: Hoffman, Hal
name: O'Shea, John J.
name: Rosenzweig, Sergio
name: Aksentijevich, Ivona
name: Jones, Janet
name: Barron, Karyl
name: Wood, Geryl
name: Rosenberg, Helene F.
name: Russo, Ricardo
name: Lipnick, Robert
name: Balow, James E.
name: Komarow, Hirsh
name: Dent, Peter
name: Remmers, Elaine F.
name: Hofmann, Sigrun R.
name: Nowak, Miroslawa
name: Austin, Frances
name: Goldbach-Mansky, Raphaela
name: Mallah, Mustapha
name: Shoham, Nitza G.
name: Moore, Terry L.
name: Mangra, Nadira
name: Watford, Wendy T.
name: Lovell, Daniel J.
name: Schikler, Kenneth
name: Adams, Barbara S.
name: Carrero, Hector
name: Kastner, Daniel L.
name: Stein, Leonard
name: Chae, Jae Jin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Neonatal-onset multisystem inflammatory disease (NOMID; also known as chronic infantile neurologic, cutaneous, articular [CINCA] syndrome) is characterized by fever, chronic meningitis, uveitis, sensorineural hearing loss, urticarial skin rash, and a characteristic deforming arthropathy. We investigated whether patients with this disorder have mutations in CIAS1, the gene which causes Muckle-Wells syndrome and familial cold autoinflammatory syndrome, two dominantly inherited disorders with some similarities to NOMID/CINCA syndrome.
Potts models with magnetic field: arithmetic, geometry, and computation
Creators: name: Dasu, Shival
name: Marcolli, Matilde
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: 82B20, 32S60, 16E20, 68Q15

description: We give a sheaf theoretic interpretation of Potts models with external magnetic field, in terms of constructible sheaves and their Euler characteristics. We show that the polynomial countability question for the hypersurfaces defined by the vanishing of the partition function is affected by changes in the magnetic field: elementary examples suffice to see non-polynomially countable cases that become polynomially countable after a perturbation of the magnetic field. The same recursive formula for the Grothendieck classes, under edge-doubling operations, holds as in the case without magnetic field, but the closed formulae for specific examples like banana graphs differ in the presence of magnetic field. We give examples of computation of the Euler characteristic with compact support, for the set of real zeros, and find a similar exponential growth with the size of the graph. This can be viewed as a measure of topological and algorithmic complexity. We also consider the computational complexity question for evaluations of the polynomial, and show both tractable and NP-hard examples, using dynamic programming.
description: 16 pages, LaTeX; v2: final version with small corrections
Quality Cowpea Seed Production Guide
Creators: name: Amayo, R.
name: Among, E.
name: Mbeyagala
name: Wandulu, J.A
Publisher: name: ITPGRFA
Year: 2020
Subjects: ITPGRFA-BSF
UGA
Cowpea
Food
W2A-PR-115
Production
Farmers
Sustainable agriculture
Pathogens and diseases
Farmers practices
Yields
Organic farming

description: Cowpea (Vigna unguiculata L. Walp), is one of the major  legume crops grown in the semi arid regions of Uganda. It  is an important food crop for the resource poor, supporting  household needs from the early seedling stages to postharvesting time. In Uganda, the crop is an eminent source  of food and household income to the resource poor and  about 90% of the crop is grown in the eastern and northern  districts of the country.

This short production guide was prepared as an easy to use guide providing farmers and field practitioners with useful information on the necessary steps for the cowpea production including, land preparation, planting, inter-cropping, fertilizers application, weeeding, drying, threshing etc. etc. They also provide useful information om the modalities for storage and pest control, seed bed preparation planting and common disease management.  This guide was developed as part of the implementation of the project “Strengthening Seed Delivery System for Dryland Cereals and Legumes in Drought-prone Areas of Uganda” funded in the 3rdcycle of the Benefit Sharing Fund (BSF) of the International Treaty on Plant Genetic Resources for Food and Agriculture (ITPGRFA) of the Food and Agriculture Organization (FAO) with financial support from the European Union (Eu).
การเสริมสร้างการพัฒนาศักยภาพแกนนำอาสาสมัครของภาคีเครือข่ายในการดูแลฟื้นฟูเยียวยาคุณภาพชีวิตของผู้สูงอายุกลุ่มคนเปราะบางอันเนื่องมาจากได้รับผลกระทบจากสถานการณ์โควิด-19 จังหวัดสระบุรี
Creators: name: อำนวย ปิ่นพิลา
Publisher: name: Program in Political Science, Faculty of Humanities and Social Sciences, Surindra Rajabhat University
Year: 2024
Subjects: พัฒนาศักยภาพ
อาสาสมัคร
คุณภาพชีวิต
คนเปราะบาง

description: วารสารการบริหารการปกครองและนวัตกรรมท้องถิ่น, 8, 2, 1-14
Bivariate left-censored Bayesian model for predicting exposure: Preliminary analysis of worker exposure during the deepwater horizon oil spill
Creators: name: Stenzel, M.R.
name: Kwok, R.K.
name: Stewart, P.A.
name: Banerjee, S.
name: Engel, L.S.
name: Sandler, D.P.
name: Groth, C.
name: Blair, A.
name: Ramachandran, G.
Publisher: name: Oxford University Press
Year: 2017

description: In April 2010, the Deepwater Horizon oil rig caught fire and exploded, releasing almost 5 million barrels of oil into the Gulf of Mexico over the ensuing 3 months. Thousands of oil spill workers participated in the spill response and clean-up efforts. The GuLF STUDY being conducted by the National Institute of Environmental Health Sciences is an epidemiological study to investigate potential adverse health effects among these oil spill clean-up workers. Many volatile chemicals were released from the oil into the air, including total hydrocarbons (THC), which is a composite of the volatile components of oil including benzene, toluene, ethylbenzene, xylene, and hexane (BTEXH). Our goal is to estimate exposure levels to these toxic chemicals for groups of oil spill workers in the study (hereafter called exposure groups, EGs) with likely comparable exposure distributions. A large number of air measurements were collected, but many EGs are characterized by datasets with a large percentage of censored measurements (below the analytic methods’ limits of detection) and/or a limited number of measurements. We use THC for which there was less censoring to develop predictive linear models for specific BTEXH air exposures with higher degrees of censoring. We present a novel Bayesian hierarchical linear model that allows us to predict, for different EGs simultaneously, exposure levels of a second chemical while accounting for censoring in both THC and the chemical of interest. We illustrate the methodology by estimating exposure levels for several EGs on the Development Driller III, a rig vessel charged with drilling one of the relief wells. The model provided credible estimates in this example for geometric means, arithmetic means, variances, correlations, and regression coefficients for each group. This approach should be considered when estimating exposures in situations when multiple chemicals are correlated and have varying degrees of censoring.
ปัจจัยที่ส่งผลต่อการตัดสินใจเลือกเข้าศึกษาต่อระดับปริญญาตรี คณะนิติรัฐศาสตร์ มหาวิทยาลัยราชภัฏร้อยเอ็ด
Creators: name: เสกสรรค์ สนวา
Publisher: name: Program in Political Science, Faculty of Humanities and Social Sciences, Surindra Rajabhat University
Year: 2024
Subjects: ปัจจัยที่ส่งผลต่อการตัดสินใจ
การตัดสินใจเลือกศึกษาต่อ
คณะนิติรัฐศาสตร์

description: วารสารการบริหารการปกครองและนวัตกรรมท้องถิ่น, 8, 2, 15-30
Autoantibodies and neuropsychiatric events at the time of systemic lupus erythematosus diagnosis: Results from an international inception cohort study
Creators: name: van Vollenhoven, R.
name: Dooley, M. A.
name: Douglas, J.
name: Gordon, C.
name: Zoma, A.
name: Qi, Q.
name: Bruce, I. N.
name: Thompson, K.
name: Steinsson, K.
name: Wallace, D. J.
name: Khamashta, M.
name: Alarcón, G. S.
name: Bae, S. C.
name: Nived, O.
name: Hanly, J. G.
name: Fortin, P. R.
name: Gladman, D.
name: Sanchez-Guerrero, J.
name: Clarke, A.
name: Farewell, V.
name: Sturfelt, G.
name: Isenberg, D.
name: Kalunian, K.
name: Manzi, S.
name: Bernatsky, S.
name: Aranow, C.
name: Urowitz, M. B.
name: Siannis, F.
name: Ginzler, E.
name: Font, J.
name: Ramsey-Goldman, R.
name: Petri, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: To examine the association between neuropsychiatric (NP) events with antiphospholipid antibodies (lupus anticoagulant, anticardiolipin), anti-β2 glycoprotein-I, anti-ribosomal P and anti-NR2 glutamate receptor antibodies in an international inception cohort.
Dynamical decoupling based quantum sensing: Floquet spectroscopy
Creators: name: Lang, J. E.
name: Liu, Ren-Bao
name: Monteiro, T. S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Sensing the internal dynamics of individual nuclear spins or clusters of nuclear spins has recently become possible by observing the coherence decay of a nearby electronic spin: the weak magnetic noise is amplified by a periodic, multi-pulse decoupling sequence. However, it remains challenging to robustly infer underlying atomic-scale structure from decoherence traces in all but the simplest cases. We introduce Floquet spectroscopy as a versatile paradigm for analysis of these experiments, and argue it offers a number of general advantages. In particular, this technique generalises to more complex situations, offering physical insight in regimes of many-body dynamics, strong coupling and pulses of finite duration. As there is no requirement for resonant driving, the proposed spectroscopic approach permits physical interpretation of striking, but overlooked, coherence decay features in terms of the form of the avoided crossings of the underlying quasienergy eigenspectrum. This is exemplified by a set of "diamond" shaped features arising for transverse-field scans in the case of single-spin sensing by NV-centers in diamond. We investigate also applications for donors in silicon showing that the resulting tunable interaction strengths offer highly promising future sensors.
The Gulf Long-Term Follow-Up Study (GuLF STUDY): Biospecimen collection at enrollment
Creators: name: Kwok, R.K.
name: Curry, M.D.
name: Miller, A.K.
name: Blair, A.
name: McGrath, J.A.
name: Sandler, D.P.
name: Engel, L.S.
Publisher: name: Taylor and Francis Inc.
Year: 2017

description: The 2010 Deepwater Horizon (DWH) explosion in the Gulf of Mexico led to the largest ever marine oil spill by volume. The GuLF STUDY is investigating possible adverse human health effects associated with oil spill activities. One objective of the study was to utilize biological specimens from study participants to examine spill-related adverse health effects. This study describes the methods for collecting, processing, shipping, and storing specimens during the enrollment phase of the study. GuLF STUDY participants living in Gulf States (Alabama, Florida, Louisiana, Mississippi, and eastern Texas) were eligible to complete a home visit at enrollment, one to three years after the DWH explosion. During this visit, blood, urine, toenail and hair clippings, and house dust samples were collected. Specimens were shipped overnight to a central processing laboratory in containers with cold and ambient temperature compartments. Most blood and urine specimens were then aliquoted and stored in liquid nitrogen vapor or at -80°C, with some samples stored at -20°C. A total of 11,193 participants completed a home visit, and over 99% provided at least one biospecimen. Most participants provided blood (93%), urine (99%), and toenail clippings (89%), and 40% provided hair. Nearly all participants (95%) provided house-dust samples. Most samples were received by the laboratory one (58%) or two (25%) days after collection. These biospecimens enable investigation of a range of biomarkers of spill-related adverse health effects, and possibly some biomarkers of spill-related exposures. The biospecimen collection, handling, and storage protocols were designed to maximize current and future scientific value within logistical and budgetary constraints and might serve as a template for future studies conducted in similar time-critical and geographically dispersed settings.
Method of averaging in Clifford algebras
Creators: name: Shirokov, D. S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: 15A66

description: In this paper we consider different operators acting on Clifford algebras. We consider Reynolds operator of Salingaros' vee group. This operator average" an action of Salingaros' vee group on Clifford algebra. We consider conjugate action on Clifford algebra. We present a relation between these operators and projection operators onto fixed subspaces of Clifford algebras. Using method of averaging we present solutions of system of commutator equations.
description: 15 pages
Uraemic extracellular vesicles augment osteogenic transdifferentiation of vascular smooth muscle cells via enhanced AKT signalling and PiT‐1 expression
Creators: name: Freise, Christian
name: Querfeld, Uwe
name: Ludwig, Antje
name: Hamm, Bernd
name: Schnorr, Jörg
name: Taupitz, Matthias
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: chronic kidney disease
subject: exosomes
subject: extracellular vesicles
subject: uraemia
subject: vascular calcification
subject: vascular smooth muscle cells
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Extracellular vesicles (EV) function as messengers between endothelial cells (EC) and vascular smooth muscle cells (VSMC). Since chronic kidney disease (CKD) increases the risk for vascular calcifications, we investigated whether EV derived from uraemic milieu-stimulated EC and derived from uraemic rats impact the osteogenic transdifferentiation/calcification of VSMC. For that purpose, human EC were treated with urea and indoxyl sulphate or left untreated. Experimental uraemia in rats was induced by adenine feeding. 'Uraemic' and control EV (EVUR; EVCTRL) were isolated from supernatants and plasma by using an exosome isolation reagent. Rat VSMC were treated with a pro-calcifying medium (CM) with or without EV supplementation. Gene expressions, miRNA contents and protein expressions were determined by qPCR and Western blots, respectively. Calcifications were determined by colorimetric assays. Delivery of miRNA inhibitors/mimics to EV and siRNA to VSMC was achieved via transfection. EVCTRL and EVUR differed in size and miRNA contents. Contrary to EVCTRL, EC- and plasma-derived EVUR significantly increased the pro-calcifying effects of CM, including altered gene expressions of osterix, runx2, osteocalcin and SM22 alpha. Further, EVUR enhanced the protein expression of the phosphate transporter PiT-1 in VSMC and induced a phosphorylation of AKT and ERK. Knock down of PiT-1 and individual inhibition of AKT and ERK signalling in VSMC blocked the pro-calcifying effects of EVUR. Similar effects were achieved by inhibition of miR-221/-222 and mimicking of miR-143/-145 in EVUR. In conclusion, EVUR might represent an additional puzzle piece of the complex pathophysiology of vascular calcifications in CKD.
Multiscale modeling of exocytosis in the fertilization process
Creators: name: Duran, Aldo Ledesma
name: Santamaria-Holek, I.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Subcellular Processes (q-bio.SC)
subject: FOS: Biological sciences

description: We discuss the implementation of a multiscale biophysico-chemical model able to cope with the main mechanisms underlying cumulative exocytosis in cells. The model is based on a diffusion equation in the presence of external forces that links calcium signaling and the biochemistry associated to the activity of cytoskeletal-based protein motors. This multiscale model offers an excellent quantitative spatio-temporal description of the cumulative exocytosis measured by means of fluorescence experiments. We also review pre-existing models reported in the literature on calcium waves, protein motor activation and dynamics, and intracellular directed transport of vesicles. As an example of the proposed model, we analyze the formation of the shield against polyspermy in the early events of fertilization in sea urchin eggs.
description: 16 pages, 9 figures, 1 table
Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part II
Creators: name: Hunder, Gene G.
name: Lawrence, Reva C.
name: Felson, David T.
name: Jordan, Joanne M.
name: Deyo, Richard A.
name: Choi, Hyon
name: Hochberg, Marc C.
name: Kremers, Hilal Maradit
name: Gabriel, Sherine
name: Arnold, Lesley M.
name: Helmick, Charles G.
name: Hirsch, Rosemarie
name: Katz, Jeffrey N.
name: Wolfe, Frederick
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: To provide a single source for the best available estimates of the US prevalence of and number of individuals affected by osteoarthritis, polymyalgia rheumatica and giant cell arteritis, gout, fibromyalgia, and carpal tunnel syndrome, as well as the symptoms of neck and back pain. A companion article (part I) addresses additional conditions.
A pooled analysis of dietary sugar/carbohydrate intake and esophageal and gastric cardia adenocarcinoma incidence and survival in the USA
Creators: name: Shaheen, N.J.
name: Engel, L.S.
name: Niehoff, N.M.
name: McClain, K.M.
name: Wu, A.H.
name: Bradshaw, P.T.
name: Risch, H.A.
name: Steck, S.E.
name: Petrick, J.L.
name: Li, N.
name: Gammon, M.D.
name: Vaughan, T.L.
Publisher: name: Oxford University Press
Year: 2017

description: Background: During the past 40 years, esophageal/gastric cardia adenocarcinoma (EA/ GCA) incidence increased in Westernized countries, but survival remained low. A parallel increase in sugar intake, which may facilitate carcinogenesis by promoting hyperglycaemia, led us to examine sugar/carbohydrate intake in association with EA/GCA incidence and survival. Methods: We pooled 500 EA cases, 529 GCA cases and 2027 controls from two US population-based case-control studies with cases followed for vital status. Dietary intake, assessed by study-specific food frequency questionnaires, was harmonized and pooled to estimate 12 measures of sugar/carbohydrate intake. Multivariable-adjusted odds ratios (ORs) and hazard ratios [95% confidence intervals (CIs)] were calculated using multinomial logistic regression and Cox proportional hazards regression, respectively. Results: EA incidence was increased by 51-58% in association with sucrose (ORQ5vs.Q1=1.51, 95% CI=1.01-2.27), sweetened desserts/beverages (ORQ5vs.Q1=1.55, 95% CI=1.06-2.27) and the dietary glycaemic index (ORQ5vs.Q1=1.58, 95% CI=1.13-2.21). Bodymass index (BMI) and gastro-esophageal reflux disease (GERD) modified these associations (Pmultiplicative-interaction ≤ 0.05). For associations with sucrose and sweetened desserts/beverages, respectively, the OR was elevated for BMI < 25 (ORQ4-5vs.Q1-3=1.79, 95% CI=1.26-2.56 and ORQ4-5vs.Q1-3=1.45, 95% CI=1.03-2.06), but not BMI≥25 (ORQ4-5vs.Q1-3=1.05, 95% CI=0.76-1.44 and ORQ4-5vs.Q1-3=0.85, 95% CI=0.62-1.16). The EA-glycaemic index association was elevated for BMI≥25 (ORQ4-5vs.Q1-3=1.38, 95% CI=1.03-1.85), but not BMI < 25 (ORQ4-5vs.Q1-3=0.88, 95% CI=0.62-1.24). The sucrose-EA association OR for GERD < weekly was 1.58 (95% CI=1.16-2.14), but for GERD≥weekly was 1.01 (95% CI=0.70-1.47). Sugar/carbohydrate measures were not associated with GCA incidence or EA/GCA survival. Conclusions: If confirmed, limiting intake of sucrose (e.g. table sugar), sweetened desserts/ beverages, and foods that contribute to a high glycaemic index, may be plausible EA risk reduction strategies.
Klinische Untersuchung der Wirksamkeit zweier Liganden am Progesteronrezeptor zur Behandlung gynäkologischer Erkrankungen
Creators: name: Seitz, Christian
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: progesteron receptor
subject: endometriosis
subject: uterine fibroids
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Die vorliegende Habilitationsschrift fasst Studien zusammen, die sich mit der klinischen Untersuchung zweier Liganden des Progesteronrezeptors (PR) befassen. Beide Moleküle wurden auf ihre Eignung zur Behandlung bestimmter gynäkologischer Erkrankungen untersucht. Dienogest, ein Gestagen und damit Agonist am Progesteronrezeptor, wurde entwickelt zur Behandlung der Endometriose und ist inzwischen für diese Indikation zugelassen. Vilaprisan, ein selektiver Modulator am Gestagenrezeptor (Selective Progesterone Receptor Modulator, SPRM) wird derzeit in Phase 3 Studien zur Behandlung von Uterusmyomen getestet. Einleitend wird zunächst die Pharmakologie beider Substanzen dargestellt und eine kurze Beschreibung der behandelten Erkrankungen gegeben. Der Hauptteil der Arbeit befasst sich mit klinischen Studien, die zur Untersuchung der Wirksamkeit und Verträglichkeit beider Substanzen durchgeführt wurden. Diese Habilitationsschrift fokussiert auf den Aspekt der Wirksamkeit. Hierzu mussten zunächst Instrumente zur Erfassung relevanter klinischer Endpunkte ausgewählt bzw. modifiziert werden. Einige Daten zur Verträglichkeit beider Substanzen werden ebenfalls präsentiert.
description: This thesis summarizes several studies which assessed clinical effects of two ligands at the progesterone receptor (PR). Both molecules were tested for their ability to treat certain gynecological disorders. Dienogest, a progestin and therefore agonist at the progesterone receptor, was developed for the treatment of endometriosis and is meanwhile approved for this indication. Vilaprisan, a selective progesterone receptor modulator (SPRM) is currently being tested in phase 3 studies for the treatment of uterine fibroids. Initially, the pharmacology of both compounds is presented, followed by a short description of both disorders. The main part covers clinical studies that were conducted to assess the efficacy and tolerability of the two compounds. The thesis focuses on the aspect of efficacy. As a pre-requisite, tools to document relevant clinical endpoints had to be developed. Some data on the tolerability of both compounds are also presented.
Inverse association of general joint hypermobility with hand and knee osteoarthritis and serum cartilage oligomeric matrix protein levels
Creators: name: Kraus, Virginia Byers
name: Chen, Hsiang-Cheng
name: Stabler, Thomas V.
name: Shah, Svati H.
name: Jordan, Joanne M.
name: Li, Yi-Ju
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Extensive joint hypermobility, lower serum cartilage oligomeric matrix protein (COMP), and early-onset osteoarthritis (OA) are phenotypes of inherited pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). However, few studies have evaluated the association between articular hypermobility and primary OA. Therefore, we evaluated this association and tested the hypothesis that COMP level is associated with hypermobility in OA and non-OA individuals.
ปัจจัยเชิงสาเหตุที่มีอิทธิพลต่อความตั้งใจซื้อผลิตภัณฑ์ผ้าย้อมครามสกลนคร ผ่านการถ่ายทอดสดทางเฟซบุ๊ก ไลฟ์
Creators: name: จีระนันต์ เจริญรัตน์
Publisher: name: Program in Political Science, Faculty of Humanities and Social Sciences, Surindra Rajabhat University
Year: 2024
Subjects: ปัจจัยเชิงสาเหตุที่มีอิทธิพล
ความตั้งใจซื้อผ้าย้อมคราม
เฟซบุ๊ก
ไลฟ์
TAM

description: วารสารการบริหารการปกครองและนวัตกรรมท้องถิ่น, 8, 2, 31-46
การยกระดับมาตรฐานและพัฒนาผลิตภัณฑ์เพื่อสร้างมูลค่าเพิ่มปลานิลลำปะทาวจังหวัดชัยภูมิ
Creators: name: ฉัตรณรงค์ศักดิ์ สุธรรม
Publisher: name: Program in Political Science, Faculty of Humanities and Social Sciences, Surindra Rajabhat University
Year: 2024
Subjects: การยกระดับมาตรฐาน
การพัฒนาผลิตภัณฑ์
การสร้างมูลค่าเพิ่ม
ปลานิล

description: วารสารการบริหารการปกครองและนวัตกรรมท้องถิ่น, 8, 2, 47-66
Local Distinguishability of Generic Unentangled Orthonormal Bases
Creators: name: Lebl, Jiri
name: Shakeel, Asif
name: Wallach, Nolan
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: 81P40 (Primary), 05C15 (Secondary)

description: An orthonormal basis consisting of unentangled (pure tensor) elements in a tensor product of Hilbert spaces is an Unentangled Orthogonal Basis (UOB). In general, for $n$ qubits, we prove that in its natural structure as a real variety, the space of UOB is a bouquet of products of Riemann spheres parametrized by a class of edge colorings of hypercubes. Its irreducible components of maximum dimension are products of $2^n-1$ two-spheres. Using a theorem of Walgate and Hardy, we observe that the UOB whose elements are distinguishable by local operations and classical communication (called locally distinguishable or LOCC distinguishable UOB) are exactly those in the maximum dimensional components. Bennett et al, in their in-depth study of quantum nonlocality without entanglement, include a specific 3 qubit example UOB which is not LOCC distinguishable; we construct certain generalized counterparts of this UOB in $n$ qubits.
description: 7 pages, 3 figures; to appear in Phys. Rev. A, title changed
การขับเคลื่อนชุมชนผ่านศูนย์ดิจิทัลชุมชนจังหวัดศรีสะเกษ
Creators: name: อลงกต แผนสนิท
Publisher: name: Program in Political Science, Faculty of Humanities and Social Sciences, Surindra Rajabhat University
Year: 2024
Subjects: กระบวนการขับเคลื่อน
ชุมชน
ศูนย์ดิจิทัลชุมชน

description: วารสารการบริหารการปกครองและนวัตกรรมท้องถิ่น, 8, 2, 67-90
Predictors of treatment resistance and relapse in antineutrophil cytoplasmic antibody-associated small-vessel vasculitis: Comparison of two independent cohorts
Creators: name: Pagnoux, Christian
name: Jennette, J. Charles
name: Hogan, Susan L.
name: Chin, Hyunsook
name: Falk, Ronald J.
name: Guillevin, Loïc
name: Nachman, Patrick H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Predictors of treatment resistance and relapse have been identified in patients with antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis in the Glomerular Disease Collaborative Network (GDCN) in the southeastern US. This study was undertaken to evaluate the applicability of those predictors in an independent cohort followed up by the French Vasculitis Study Group.
Photonic Floquet Topological Insulator in an Atomic Ensemble
Creators: name: Zhang, Yiqi
name: Wu, Zhenkun
name: Belić, Milivoj R.
name: Zheng, Huaibin
name: Wang, Zhiguo
name: Xiao, Min
name: Zhang, Yanpeng
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We demonstrate the photonic Floquet topological insulator (PFTI) in an atomic vapor with nonlinear susceptibilities. The interference of three coupling fields splits the energy levels periodically to form a periodic refractive index structure with honeycomb symmetry that can be adjusted by the choice of frequency detunings and intensities of the coupling fields, which all affect the appearance of Dirac cones in the momentum space. When the honeycomb lattice sites are helically ordered along the propagation direction, we obtain a PFTI in the atomic vapor in which an obliquely incident beam moves along the zigzag edge without scattering energy into the PFTI, due to the confinement of the edge states. The appearance of Dirac cones and the formation of PFTI is strongly affected by the nonlinear susceptibilities; i.e. the PFTI can be shut off by the third-order nonlinear susceptibility and re-opened up by the fifth-order one.
description: 14 pages, 6 figures
High‐Sensitivity Cardiac Troponin T and Recurrent Vascular Events After First Ischemic Stroke
Creators: name: Scheitz, Jan F.
name: Lim, Jess
name: Broersen, Leonie H. A.
name: Ganeshan, Ramanan
name: Huo, Shufan
name: Sperber, Pia S.
name: Piper, Sophie K.
name: Heuschmann, Peter U.
name: Audebert, Heinrich J.
name: Nolte, Christian H.
name: Siegerink, Bob
name: Endres, Matthias
name: Liman, Thomas G.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: epidemiology
subject: ischemic stroke
subject: mortality
subject: survival
subject: troponin
subject: vascular disease
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Recent evidence suggests cardiac troponin levels to be a marker of increased vascular risk. We aimed to assess whether levels of high-sensitivity cardiac troponin T (hs-cTnT) are associated with recurrent vascular events and death in patients with first-ever, mild to moderate ischemic stroke. Methods and Results: We used data from the PROSCIS-B (Prospective Cohort With Incident Stroke Berlin) study. We computed Cox proportional hazards regression analyses to assess the association between hs-cTnT levels upon study entry (Roche Elecsys, upper reference limit, 14 ng/L) and the primary outcome (composite of recurrent stroke, myocardial infarction, and all-cause death). A total of 562 patients were analyzed (mean age, 67 years [SD 13]; 38.6% women; median National Institutes of Health Stroke Scale=2; hs-cTnT above upper reference limit, 39.2%). During a mean follow-up of 3 years, the primary outcome occurred in 89 patients (15.8%), including 40 (7.1%) recurrent strokes, 4 (0.7%) myocardial infarctions, and 51 (9.1%) events of all-cause death. The primary outcome occurred more often in patients with hs-cTnT above the upper reference limit (27.3% versus 10.2%; adjusted hazard ratio, 2.0; 95% CI, 1.3-3.3), with a dose-response relationship when the highest and lowest hs-cTnT quartiles were compared (15.2 versus 1.8 events per 100 person-years; adjusted hazard ratio, 4.8; 95% CI, 1.9-11.8). This association remained consistent in sensitivity analyses, which included age matching and stratification for sex. Conclusions: Hs-cTnT is dose-dependently associated with an increased risk of recurrent vascular events and death within 3 years after first-ever, mild to moderate ischemic stroke. These findings support further studies of the utility of hs-cTnT for individualized risk stratification after stroke. Registration URL: ; Unique identifier: NCT01363856.
Dietary sugar/starches intake and Barrett’s esophagus: a pooled analysis
Creators: name: Gammon, M.D.
name: Petrick, J.L.
name: McClain, K.M.
name: Engel, L.S.
name: Niehoff, N.M.
name: Shaheen, N.J.
name: Corley, D.A.
name: Steck, S.E.
name: Bradshaw, P.T.
name: Vaughan, T.L.
name: Li, N.
Publisher: name: Springer Netherlands
Year: 2017

description: Barrett’s esophagus (BE) is the key precursor lesion of esophageal adenocarcinoma, a lethal cancer that has increased rapidly in westernized countries over the past four decades. Dietary sugar intake has also been increasing over time, and may be associated with these tumors by promoting hyperinsulinemia. The study goal was to examine multiple measures of sugar/starches intake in association with BE. This pooled analysis included 472 BE cases and 492 controls from two similarly conducted case–control studies in the United States. Dietary intake data, collected by study-specific food frequency questionnaires, were harmonized across studies by linking with the University of Minnesota Nutrient Database, and pooled based on study-specific quartiles. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for age, sex, race, total energy intake, study indicator, body mass index, frequency of gastro-esophageal reflux, and fruit/vegetable intake. In both studies, intake of sucrose (cases vs. controls, g/day: 36.07 vs. 33.51; 36.80 vs. 35.06, respectively) and added sugar (46.15 vs. 41.01; 44.18 vs. 40.68, respectively) were higher in cases than controls. BE risk was increased 79% and 71%, respectively, for associations comparing the fourth to the first quartile of intake of sucrose (ORQ4vs.Q1 = 1.79, 95% CI = 1.07–3.02, Ptrend = 0.01) and added sugar (ORQ4vs.Q1 = 1.71, 95% CI = 1.05–2.80, Ptrend = 0.15). Intake of sweetened desserts/beverages was associated with 71% increase in BE risk (ORQ4vs.Q1 = 1.71, 95% CI = 1.07–2.73, Ptrend = 0.04). Limiting dietary intake of foods and beverages that are high in added sugar, especially refined table sugar, may reduce the risk of developing BE.