title: ÐÐµÐ½ÐµÑÐ¸ÑÐµÑÐºÐ°Ñ Ð¿ÑÐµÐ´ÑÐ°ÑÐ¿Ð¾Ð»Ð¾Ð¶ÐµÐ½Ð½Ð¾ÑÑÑ Ðº ÑÑÐ¿ÐµÑÐ½Ð¾Ð¹ Ð°Ð´Ð°Ð¿ÑÐ°ÑÐ¸Ð¸ Ðº Ð²ÑÑÐ¾ÐºÐ¸Ð¼ ÑÐ¸ÑÐ¾ÑÐ°Ð¼
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Genetic predisposition to successful adaptation to high widths
Creators: name: ÐÑÑÐ¾Ð², ÐÐ»Ð°Ð´Ð¸ÑÐ»Ð°Ð²
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: Ð°Ð½Ð³Ð¸Ð¾ÑÐµÐ½Ð·Ð¸Ð½-Ð¿ÑÐµÐ²ÑÐ°ÑÐ°ÑÑÐ¸Ð¹ ÑÐµÑÐ¼ÐµÐ½Ñ
ÑÐµÑÐµÐ¿ÑÐ¾Ñ ÑÐµÑÐ¾ÑÐ¾Ð½Ð¸Ð½Ð° 2Ð
Ð½ÐµÐ¹ÑÐ¾ÑÑÐ¾ÑÐ¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ°ÐºÑÐ¾Ñ BDNF
Ð°Ð»ÑÑÐ°-Ð°ÐºÑÐ¸Ð½Ð¸Ð½-3
ÐÑÐºÑÐ¸ÐºÐ°
angiotensin-converting enzyme
serotonin 2A receptor
neurotrophic factor BDNF
alpha-actinin-3
the Arctic

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð³ÐµÐ½ÐµÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð±Ð°Ð·Ñ Ð´Ð»Ñ Ð¿ÑÐ¸ÑÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð°Ð´Ð°Ð¿ÑÐ°ÑÐ¸Ð¸ ÑÐµÐ»Ð¾Ð²ÐµÐºÐ° ÑÐºÑÑÑÐµÐ¼Ð°Ð»ÑÐ½ÑÐ¼ ÐºÐ»Ð¸Ð¼Ð°ÑÐ¸ÑÐµÑÐºÐ¸Ð¼ ÑÑÐ»Ð¾Ð²Ð¸ÑÐ¼. ÐÐ»Ñ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð±ÑÐ»Ð¸ Ð²ÑÐ±ÑÐ°Ð½Ñ Ð´Ð²Ðµ Ð³ÑÑÐ¿Ð¿Ñ Ð¿ÑÐ°ÐºÑÐ¸ÑÐµÑÐºÐ¸ Ð·Ð´Ð¾ÑÐ¾Ð²ÑÑ Ð»ÑÐ´ÐµÐ¹, Ð²ÑÐ¿Ð¾Ð»Ð½ÑÑÑÐ¸Ñ Ð¾Ð¿ÐµÑÐ°ÑÐ¾ÑÑÐºÑÑ Ð´ÐµÑÑÐµÐ»ÑÐ½Ð¾ÑÑÑ. Ð¦ÐµÐ»ÐµÐ²Ð°Ñ Ð³ÑÑÐ¿Ð¿Ð° ÑÐ¾ÑÑÐ¾Ð¸Ñ Ð¸Ð· Ð»Ð¸Ñ, Ð¿ÑÐ¾Ð¶Ð¸Ð²Ð°ÑÑÐ¸Ñ Ð² ÑÐºÑÑÑÐµÐ¼Ð°Ð»ÑÐ½ÑÑ ÑÑÐ»Ð¾Ð²Ð¸ÑÑ ÐÑÐºÑÐ¸ÐºÐ¸. ÐÐ¾Ð½ÑÑÐ¾Ð»ÑÐ½Ð°Ñ Ð³ÑÑÐ¿Ð¿Ð° ÑÐ¾ÑÑÐ¾Ð¸Ñ Ð¸Ð· Ð»Ð¸Ñ, Ð¿ÑÐ¾Ð¶Ð¸Ð²Ð°ÑÑÐ¸Ñ Ð² ÑÑÐ»Ð¾Ð²Ð¸ÑÑ ÑÑÐµÐ´Ð½ÐµÐ¹ Ð¿Ð¾Ð»Ð¾ÑÑ Ð Ð¾ÑÑÐ¸Ð¸. ÐÐ»Ñ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ñ ÑÑÐ¾Ð²Ð½Ñ Ð°Ð´Ð°Ð¿ÑÐ°ÑÐ¸Ð¸ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð»ÑÑ Ð½Ð°Ð±Ð¾Ñ Ð¿ÑÐ¸ÑÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ ÑÐµÑÑÐ¾Ð², Ð¿ÑÐ¸Ð½Ð°Ð´Ð»ÐµÐ¶Ð°ÑÐ¸Ñ ÑÑÐ°Ð½Ð´Ð°ÑÑÐ½Ð¾Ð¼Ñ Ð¸Ð½ÑÑÑÑÐ¼ÐµÐ½ÑÐ°ÑÐ¸Ñ ÑÐ¾Ð²ÑÐµÐ¼ÐµÐ½Ð½Ð¾Ð¹ Ð¿ÑÐ¸ÑÐ¾Ð´Ð¸Ð°Ð³Ð½Ð¾ÑÑÐ¸ÐºÐ¸. ÐÐ»Ñ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¸Ñ Ð³ÐµÐ½ÐµÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¾Ð±ÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ñ Ð¾Ð±ÑÐ»ÐµÐ´ÑÐµÐ¼ÑÑ Ð±ÑÐ»Ð° Ð²Ð·ÑÑÐ° ÑÐµÐ»ÑÐ½Ð°Ñ ÐºÑÐ¾Ð²Ñ Ð¸Ð· Ð²ÐµÐ½Ñ, Ð¸Ð· ÐºÐ¾ÑÐ¾ÑÐ¾Ð¹ Ð²ÑÐ´ÐµÐ»ÑÐ»Ð°ÑÑ ÐÐÐ Ñ Ð¿Ð¾ÑÐ»ÐµÐ´ÑÑÑÐ¸Ð¼ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð¿Ð¾Ð»Ð¸Ð¼Ð¾ÑÑÐ¸Ð·Ð¼Ð¾Ð² ACE Ins/Del (rs4646994), ACTN3 R577X (rs1815739), BDNF Val66Met (rs6265) Ð¸ HTR2A T102C (rs6313) Ð¼ÐµÑÐ¾Ð´Ð¾Ð¼ ÐÐ¦Ð  Ð² ÑÐµÐ°Ð»ÑÐ½Ð¾Ð¼ Ð²ÑÐµÐ¼ÐµÐ½Ð¸.Â ÐÑÐ»Ð¸ Ð¿Ð¾Ð»ÑÑÐµÐ½Ñ Ð´Ð°Ð½Ð½ÑÐµ, ÑÐ¾Ð³Ð»Ð°ÑÐ½Ð¾ ÐºÐ¾ÑÐ¾ÑÑÐ¼ Ð¿ÑÐ¾ÑÐ»ÐµÐ¶Ð¸Ð²Ð°ÐµÑÑÑ ÑÐ²ÑÐ·Ñ Ð¼ÐµÐ¶Ð´Ñ Ð²Ð°ÑÐ¸Ð°Ð½ÑÐ°Ð¼Ð¸ Ð´Ð°Ð½Ð½ÑÑ Ð¿Ð¾Ð»Ð¸Ð¼Ð¾ÑÑÐ¸Ð·Ð¼Ð¾Ð² Ð¸ ÑÐ¾ÑÐ¸Ð°Ð»ÑÐ½Ð¾-Ð¿ÑÐ¸ÑÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð¹ Ð°Ð´Ð°Ð¿ÑÐ°ÑÐ¸ÐµÐ¹ Ðº ÑÐºÑÑÑÐµÐ¼Ð°Ð»ÑÐ½ÑÐ¼ ÑÑÐ»Ð¾Ð²Ð¸ÑÐ¼ Ð²ÑÑÐ¾ÐºÐ¸Ñ ÑÐ¸ÑÐ¾Ñ. Ð¡Ð¾Ð³Ð»Ð°ÑÐ½Ð¾ ÑÑÐ¸Ð¼ Ð´Ð°Ð½Ð½ÑÐ¼, Ð¿Ð¾Ð»Ð¸Ð¼Ð¾ÑÑÐ¸Ð·Ð¼Ñ Ð³ÐµÐ½Ð¾Ð² BDNF Ð¸ ACE Ð¾ÐºÐ°Ð·ÑÐ²Ð°ÑÑ Ð·Ð½Ð°ÑÐ¸Ð¼Ð¾Ðµ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ Ð½Ð° Ð°Ð´Ð°Ð¿ÑÐ°ÑÐ¸Ñ. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¼Ð¾Ð³ÑÑ Ð±ÑÑÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ñ Ð´Ð»Ñ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¸Ñ Ð³ÐµÐ½ÐµÑÐ¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐµÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ñ ÑÐµÐ»ÑÑ Ð¿ÑÐµÐ´ÑÐºÐ°Ð·Ð°Ð½Ð¸Ñ Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½Ð¾Ð¹ ÑÐ¿Ð¾ÑÐ¾Ð±Ð½Ð¾ÑÑÐ¸ Ð°Ð´Ð°Ð¿ÑÐ°ÑÐ¸Ð¸ Ð»ÑÐ´ÐµÐ¹ Ðº ÑÐºÑÑÑÐµÐ¼Ð°Ð»ÑÐ½ÑÐ¼ ÑÑÐ»Ð¾Ð²Ð¸ÑÐ¼ Ð²ÑÑÐ¾ÐºÐ¸Ñ ÑÐ¸ÑÐ¾Ñ.
description: The given work is devoted to the study of the genetic basis for the psychological adaptation of a person to extreme climatic conditions. Two groups of practically healthy people performing operator activities were selected for the study. The target group consists of people living in the extreme conditions of the Arctic. The control group consists of people living in the conditions of the central part of Russia. To determine the level of adaptation, a set of psychological tests belonging to the standard tools of modern psychodiagnostics was used. To conduct a genetic examination, whole blood was taken from a vein from which DNA was isolated, followed by a real-time PCR study of ACE Ins/Del (rs4646994), ACTN3 R577X (rs1815739), BDNF Val66Met (rs6265) and HTR2A T102C (rs6313) polymorphisms. Data were obtained, according to which there is a connection between the variants of these polymorphisms and socio-psychological adaptation to extreme conditions of high latitudes. According to these data, polymorphisms of the BDNF and ACE genes have a significant effect on adaptation. The results obtained can be used for genetic testing in order to predict the possible ability of people to adapt to extreme conditions of high latitudes.