cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Sprachliche Imitation
title: Jiddisch in der deutschsprachigen Literatur (18.-20. Jahrhundert)
titleType: Subtitle
Creators: name: Schäfer, Lea
Publisher: name: Language Science Press
Year: 2016

description: Diese Arbeit beschäftigt sich mit den Strukturen fiktionaler, imitierender Sprache. Am Beispiel detaillierter Analysen der sprachlichen Charakterisierung jüdischer Figuren der deutschsprachigen Literatur des 18., 19. und frühen 20. Jahrhunderts legt die Arbeit offen, welche Strukturen die jiddische Sprachrealität widerspiegeln und welche als Reflexe der (zumeist autoreigenen) Mündlichkeit gelten können. Zugleich stellt die Untersuchung eine umfangreiche grammatische Darstellung des im deutschsprachigen Raum bis ins frühe 20. Jahrhundert hinein verbreiteten Westjiddischen dar, dessen Strukturen sie mit denen deutscher und ostjiddischer Varietäten vergleicht.
This book contains a study on fictional, imitated language. In detailed analyses it shows how Jewish figures were characterized through their language in German fiction (18th until early 20th century). It discloses which structures of this fictional language originate from the Yiddish language and which are reflexes of (the author's) orality. At the same time the study contains a comprehensive description of Western Yiddish and its grammatical structures, which are compared with German and Eastern Yiddish varieties.
 
 
German law requires we state the prices in Germany for this publication. The hardcover price is 70.00 EUR; the softcover price is 64.20 EUR.
description: Language Variation
Supplemental Material, Appendix - Nonlinear thermomechanical buckling of sandwich FGM oblique stiffened plates with nonlinear effect of elastic foundation
Creators: name: Dong, Dang Thuy
name: Nam, Vu Hoai
name: Trung, Nguyen Thoi
name: Phuong, Nguyen Thi
name: Hung, Vu Tho
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental Material, Appendix for Nonlinear thermomechanical buckling of sandwich FGM oblique stiffened plates with nonlinear effect of elastic foundation by Dang Thuy Dong, Vu Hoai Nam, Nguyen Thoi Trung, Nguyen Thi Phuong and Vu Tho Hung in Journal of Thermoplastic Composite Materials
Paracanthopoma parva Giltay 1935
Creators: name: Escobar-Camacho, Daniel
name: Valdiviezo-Rivera, Jonathan
name: Carrillo-Moreno, Carolina
name: Argüello, Pablo
name: Swing, Kelly
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Siluriformes
Trichomycteridae
Paracanthopoma
Paracanthopoma parva

description: Paracanthopoma parva Giltay 1935
Distribution
Amazonia.
Notes
Barriga (1994).
description: Published as part of Escobar-Camacho, Daniel, Valdiviezo-Rivera, Jonathan, Carrillo-Moreno, Carolina, Argüello, Pablo & Swing, Kelly, 2025, Exceptional concentration of fish diversity in Yasuní National Park, Ecuador (Napo River Basin), pp. e 136476 in Biodiversity Data Journal 13 on page e136476, DOI: 10.3897/BDJ.13.e136476
Additional file 1 of Self-reported skills and self-confidence in point-of-care ultrasound: a cross-sectional nationwide survey amongst Finnish emergency physicians
Creators: name: Hannula, Ossi
name: Hällberg, Ville
name: Meuronen, Anna
name: Suominen, Olli
name: Rautiainen, Suvi
name: Palomäki, Ari
name: Hyppölä, Harri
name: Vanninen, Ritva
name: Mattila, Kalle
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1.
Plectrochilus wieneri
Creators: name: Escobar-Camacho, Daniel
name: Valdiviezo-Rivera, Jonathan
name: Carrillo-Moreno, Carolina
name: Argüello, Pablo
name: Swing, Kelly
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Siluriformes
Trichomycteridae
Plectrochilus
Plectrochilus wieneri

description: Plectrochilus wieneri (Pellegrin 1909)
Distribution
Napo Basin in Ecuador.
Notes
Barriga (1994).
description: Published as part of Escobar-Camacho, Daniel, Valdiviezo-Rivera, Jonathan, Carrillo-Moreno, Carolina, Argüello, Pablo & Swing, Kelly, 2025, Exceptional concentration of fish diversity in Yasuní National Park, Ecuador (Napo River Basin), pp. e 136476 in Biodiversity Data Journal 13 on page e136476, DOI: 10.3897/BDJ.13.e136476
Raman Compressive Sensing
Creators: name: Raj, Piyush
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 310299
subject: Bioinformatics and computational biology not elsewhere classified

description: Data in support of publication in ACS Sensors [2024] journal.
Paper Title: To acquire or not to acquire: Evaluating compressive sensing for Raman spectroscopy in biology
Supplemental Material, BASC_English_version - Exploring the Score Equivalence of the English and Chinese Versions of the Brief Assessment Scale for Caregivers
Creators: name: Yang, Grace Meijuan
name: Shirlyn Hui-Shan Neo
name: Teo, Irene
name: Geok Ling Lee
name: Thumboo, Julian
name: Chia, John
name: Lau, Annie
name: Koh, Audrey
name: Qu, Debra
name: Che, William Wai Lam
name: Hwee Lin Wee
name: Glajchen, Myra
name: Cheung, Yin Bun
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: Medicine

description: Supplemental Material, BASC_English_version for Exploring the Score Equivalence of the English and Chinese Versions of the Brief Assessment Scale for Caregivers by Grace Meijuan Yang, Shirlyn Hui-Shan Neo, Irene Teo, Geok Ling Lee, Julian Thumboo, John Chia, Annie Lau, Audrey Koh, Debra Qu, William Wai Lam Che, Hwee Lin Wee, Myra Glajchen, and Yin Bun Cheung in Journal of Patient Experience
Pseudostegophilus nemurus
Creators: name: Escobar-Camacho, Daniel
name: Valdiviezo-Rivera, Jonathan
name: Carrillo-Moreno, Carolina
name: Argüello, Pablo
name: Swing, Kelly
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Siluriformes
Trichomycteridae
Pseudostegophilus
Pseudostegophilus nemurus

description: Pseudostegophilus nemurus (Günther 1869)
Distribution
Amazonia.
Notes
Barriga (1994), Barriga (2011), Guarderas and Jácome-Negrete (2013).
description: Published as part of Escobar-Camacho, Daniel, Valdiviezo-Rivera, Jonathan, Carrillo-Moreno, Carolina, Argüello, Pablo & Swing, Kelly, 2025, Exceptional concentration of fish diversity in Yasuní National Park, Ecuador (Napo River Basin), pp. e 136476 in Biodiversity Data Journal 13 on page e136476, DOI: 10.3897/BDJ.13.e136476
Schultzichthys bondi
Creators: name: Escobar-Camacho, Daniel
name: Valdiviezo-Rivera, Jonathan
name: Carrillo-Moreno, Carolina
name: Argüello, Pablo
name: Swing, Kelly
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Siluriformes
Trichomycteridae
Schultzichthys
Schultzichthys bondi

description: Schultzichthys bondi (Myers 1942)
Distribution
Amazonia, Orinoco.
Notes
Barriga (1994), Barriga (2011).
description: Published as part of Escobar-Camacho, Daniel, Valdiviezo-Rivera, Jonathan, Carrillo-Moreno, Carolina, Argüello, Pablo & Swing, Kelly, 2025, Exceptional concentration of fish diversity in Yasuní National Park, Ecuador (Napo River Basin), pp. e 136476 in Biodiversity Data Journal 13 on page e136476, DOI: 10.3897/BDJ.13.e136476
Supplemental_Material_Updated – Supplemental material for Mass Media as a Source of Public Responsiveness
Creators: name: Neuner, Fabian G.
name: Soroka, Stuart N.
name: Wlezien, Christopher
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications
subject: 160607 International Relations
subject: FOS: Political science

description: Supplemental material, Supplemental_Material_Updated for Mass Media as a Source of Public Responsiveness by Fabian G. Neuner, Stuart N. Soroka and Christopher Wlezien in The International Journal of Press/Politics
Pasture growth simulation and sensitivity analysis using APSIM-related models in a tropical silvopastoral system
Creators: name: Fillietaz Balcão, Lucas
name: Andreucci, Mariana
name: Snow, Val
name: Holzworth, Dean
name: Bauab Brunetti, Henrique
name: Lopes dos Santos, Mariely
name: Bosi, Cristiam
name: Pezzopane, José
name: Menezes Santos, Patricia
Publisher: name: AgResearch
Year: 2024
Subjects: classificationCode: 3004
subject: Crop and pasture production

description: Silvopastoral systems integrate trees, pastures, and animals aiming for sustainable livestock production. The APSIM model has been used to simulate silvopastoral systems but the estimates of light transmission through the tree canopies, belowground water competition, and their effects on pasture production, have not been well adjusted. Thus, we improved the simulation of pasture growth within a silvopastoral system by integrating the APSIM-Tropical Pasture and APSIM-Slurps models and calibrated the coupled models to simulate light transmission through the trees along with water competition among species. Observed data was obtained from a silvopastoral system established in São Carlos, SP, Brazil, during two experimental periods that went from Dec-2014 until May-2016 and from Apr-2018 until May-2019. The calibration of the combination of the models was considered overall accurate. The APSIM-Slurp model simulated well (R² = 0.64, NSE = 0.60) the radiation interception by trees. The APSIM-Tropical Pasture model showed a good performance to simulate pasture (R² = 0.90 and NSE = 0.72), leaf (R² = 0.82 and NSE = 0.44), and stem (R² = 0.82 NSE = 0.75) biomass and an acceptable performance for pasture LAI (R² = 0.76 and NSE = 0.58). With that, a multifactorial simulation was performed to test the sensitivity of pasture production as a function of levels of nitrogen, tree leaf area index (LAI), tree root water extraction coefficient, post grazing residual biomass, and season of the year, using 39 years of weather data from the same location of the field experiment as input. The sensitivity analysis showed that the combination of the models was sensitive to variations of the factors with the greatest sensitivity occurring for the tree LAI. The assembling of APSIM-Tropical Pasture and APSIM-Slurp models well simulated pasture production in a silvopastoral system with different managements, indicating the potential of its use as a decision-making tool for silvopastoral systems´ design.
supplemental – Supplemental material for Reporting on the level of validity and reliability of questionnaires measuring Katakori severity: A systematic review
Creators: name: Aoki, Kaori
name: Hall, Toby
name: Takasaki, Hiroshi
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: Cardiology
subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine
subject: 110305 Emergency Medicine
subject: 110306 Endocrinology
subject: 110308 Geriatrics and Gerontology
subject: 110904 Neurology and Neuromuscular Diseases
subject: 111099 Nursing not elsewhere classified
subject: 111199 Nutrition and Dietetics not elsewhere classified
subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: 110314 Orthopaedics
subject: 110604 Sports Medicine
subject: 110315 Otorhinolaryngology
subject: 111702 Aged Health Care
subject: 111403 Paediatrics
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 110203 Respiratory Diseases
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology
subject: 110323 Surgery
subject: 70706 Veterinary Medicine
subject: FOS: Veterinary sciences

description: Supplemental material, supplemental for Reporting on the level of validity and reliability of questionnaires measuring Katakori severity: A systematic review by Kaori Aoki, Toby Hall and Hiroshi Takasaki in SAGE Open Medicine
Tridens melanops Eigenmann & Eigenmann 1889
Creators: name: Escobar-Camacho, Daniel
name: Valdiviezo-Rivera, Jonathan
name: Carrillo-Moreno, Carolina
name: Argüello, Pablo
name: Swing, Kelly
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Siluriformes
Trichomycteridae
Tridens
Tridens melanops

description: Tridens melanops Eigenmann & Eigenmann 1889
Distribution
Western and central Amazonia.
description: Published as part of Escobar-Camacho, Daniel, Valdiviezo-Rivera, Jonathan, Carrillo-Moreno, Carolina, Argüello, Pablo & Swing, Kelly, 2025, Exceptional concentration of fish diversity in Yasuní National Park, Ecuador (Napo River Basin), pp. e 136476 in Biodiversity Data Journal 13 on page e136476, DOI: 10.3897/BDJ.13.e136476
Predict_CR_AML_Supplemental_xyz13921555f86f3 – Supplemental material for Predicting Complete Remission of Acute Myeloid Leukemia: Machine Learning Applied to Gene Expression
Creators: name: Gal, Ophir
name: Auslander, Noam
name: Fan, Yu
name: Meerzaman, Daoud
Publisher: name: SAGE Journals
Year: 2019
Subjects: Biological Sciences not elsewhere classified

description: Supplemental material, Predict_CR_AML_Supplemental_xyz13921555f86f3 for Predicting Complete Remission of Acute Myeloid Leukemia: Machine Learning Applied to Gene Expression by Ophir Gal, Noam Auslander, Yu Fan and Daoud Meerzaman in Cancer Informatics
Systemische Organisationsberatung - Integration von Fach- und Prozess-Know-how : Beobachtungen - Interventionen - Reflexion eines grossflächigen Change Prozesses in einem Familiengeführten Dienstleistungsunternehmen
Creators: name: Schmid, Rainer
Publisher: name: ZHAW Zürcher Hochschule für Angewandte Wissenschaften
Year: 2015
Subjects: 150: Psychologie

description: Seit dem Jahr 2000 ist der Autor als selbständiger Organisationsberater, Führungskräftetrainer und Management Coach im Dreiländereck Schweiz, Deutschland und Österreich unterwegs. Lag zu Beginn seiner Selbständigkeit vor 15 Jahren der Fokus seiner Arbeit noch eher in fachlicher Fachberatung zu Personalmanagement Themen, hat sich dies in den letzten Jahren immer mehr vermischt in Fach- und Prozessberatung.

Heute fusst sein Beratungsverständnis in einer systemischen (ganzheitlichen) Organisationsberatung von Unternehmen. In der Berater Community wird für das gleichzeitige Nebeneinander von Fach- und Prozessberatung häufig der Begriff ,Komplementärberatung' verwendet.

Mit der Veröffentlichung des Buches „Komplementärberatung“ wurde im Jahr 2006 die Debatte um die Zukunft des Beratungsgeschäfts mit einem konkreten Ansatz von Roswita Königswieser et al. neu lanciert. Insbesondere im Kreis der Organisationsentwickler und Prozessberater findet bis heute eine Diskussion statt, die an Kongressen und in Medien zum Teilzugespitzt, mithin auch polemisch, geführt wird.

Das Ziel der vorliegenden Masterarbeit liegt einerseits in der adäquaten, theoriegeleiteten Darstellung des Wesens der Komplementärberatung. Anderseits in der kritischen Fallreflexion der Vorgehensweise und der eingesetzten Interventionen in einem grossflächigen Veränderungsprozess eines Familiengeführten Dienstleistungsunternehmen.

Zusätzlich soll fokussiert der eigene komplexe Entwicklungs-, Lern und Reflexionsprozess des Organisationsberaters in seinen verschiedenen Rollen an Transparenz gewinnen und Entwicklungspotenziale für die kommenden Jahre ansatzweise aufzeigen.
Supplemental_Material – Supplemental material for Using Harter and Likert Response Formats in Middle Childhood: A Comparison of Attachment Measures
Creators: name: Marci, Tatiana
name: Moscardino, Ughetta
name: Lionetti, Francesca
name: Santona, Alessandra
name: Altoé, Gianmarco
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, Supplemental_Material for Using Harter and Likert Response Formats in Middle Childhood: A Comparison of Attachment Measures by Tatiana Marci, Ughetta Moscardino, Francesca Lionetti, Alessandra Santona and Gianmarco Altoé in Assessment
Swiss CSR Monitor 2006 : Die gesellschaftliche Verantwortung von Unternehmen in der Wahrnehmung der Schweizer Bevölkerung. Mit einem Schwerpunkt zu Banken und Pensionskassen
Creators: name: Furrer, Bettina
name: Weiss Sampietro, Theresia
name: Seidler, Alexander
Publisher: name: ZHAW Zürcher Hochschule für Angewandte Wissenschaften
Year: 2006
Subjects: Gesellschaftliche Verantwortung von Unternehmen
Banken
Pensionskassen
Bevölkerungsbefragung
Banking industry
Corporate social responsibility
Pension funds
Survey
650: Management

description: Der Swiss CSR Monitor hat zum Ziel, periodisch die öffentliche Meinung in der Schweiz zur gesellschaftlichen Verantwortung von Unternehmen zu erheben. Damit soll Firmen aufgezeigt werden, welche Erwartungen die Öffentlichkeit an sie hat. Unternehmen können aus den Ergebnissen soziale Chancen und Risiken ihrer Tätigkeit ableiten. Der Swiss CSR Monitor 2006 stellt die Ergebnisse der Umfrage im Jahr 2006 dar.
Tridentopsis pearsoni Myers 1925
Creators: name: Escobar-Camacho, Daniel
name: Valdiviezo-Rivera, Jonathan
name: Carrillo-Moreno, Carolina
name: Argüello, Pablo
name: Swing, Kelly
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Siluriformes
Trichomycteridae
Tridentopsis
Tridentopsis pearsoni

description: Tridentopsis pearsoni Myers 1925
Distribution
Western, south-western Amazonia.
Notes
Galacatos et al. (2004).
description: Published as part of Escobar-Camacho, Daniel, Valdiviezo-Rivera, Jonathan, Carrillo-Moreno, Carolina, Argüello, Pablo & Swing, Kelly, 2025, Exceptional concentration of fish diversity in Yasuní National Park, Ecuador (Napo River Basin), pp. e 136476 in Biodiversity Data Journal 13 on page e136476, DOI: 10.3897/BDJ.13.e136476
PROVINCES AND GOVERNORS IN THE ERA OF THE PROPHET (1-11 AH) (622-632 AD)
Creators: name: ELBANE MAHFOUDH ELIDRISSI
name: SULEIMAN SALEM ALSARAIREH
Publisher: name: Zenodo
Year: 2025
Subjects: Era of Prophethood, Provinces, Governors, Regions, Embracing Islam.

description: Abstract

This paper has discussed a topic of utmost importance, shedding light on the initial steps taken towards the establishment of Islamic state during the era of prophethood, and the stages that the state went through from the migration of the Prophet (peace be upon him) until his death. The paper has also investigated the factors that influenced the geographical and political expansion of the state until its primary foundation was established, with all tribes and socio-political entities in the Arabian Peninsula declaring their allegiance to the state, either by embracing Islam or seeking protection as non-Muslim subjects (dhimmis). The paper has explored the stages through which Islam entered all the regions that formed the Islamic state, providing an overview of these regions, their inhabitants, and the religions of their people before the advent of Islam. It has documented examples of correspondence between the Prophet (peace be upon him) and the tribal leaders, inviting them to Islam and explaining its principles, and he promised to maintain their leadership positions if they responded positively to his invitation. Furthermore, the paper has presented profiles of the governors appointed by the Prophet (peace be upon him) and discusses the criteria for their selection. It has also presented examples of the recommendations and guidance that the Prophet (peace be upon him) provided to these governors. The study has concluded with several significant findings. Firstly, it has highlighted the enormous impact of the conquest of Makkah in the eighth year of the Hijra on the tribes' declaration of their acceptance of Islam. Some of the tribes embraced Islam out of genuine conviction, while others believed they could not resist the growing power of the Islamic state. Secondly, the paper also highlighted the criteria adopted by the Prophet (peace be upon him) in selecting governors, which confirmed that he did not appoint individuals who actively sought positions of power and governance.
ObaidiOpenPracticesDisclosure – Supplemental material for Group-Based Relative Deprivation Explains Endorsement of Extremism Among Western-Born Muslims
Creators: name: Obaidi, Milan
name: Bergh, Robin
name: Akrami, Nazar
name: Anjum, Gulnaz
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: Neuroscience

description: Supplemental material, ObaidiOpenPracticesDisclosure for Group-Based Relative Deprivation Explains Endorsement of Extremism Among Western-Born Muslims by Milan Obaidi, Robin Bergh, Nazar Akrami and Gulnaz Anjum in Psychological Science
Prozessoptimierung als Instrument der Qualitätssicherung : Theoretische Grundlagen und praktische Darstellung eines Optimierungsprozesses in der Stiftung Opferhilfe
Creators: name: Huber, Brigitte
Publisher: name: ZHAW Zürcher Hochschule für Angewandte Wissenschaften
Year: 2009
Subjects: Prozessmanagement
Qualitätsmanagement
650: Management

description: Die Arbeit gibt Antworten auf Fragen zur Bedeutung der prozessorientierten Sichtweise als Gestaltungsprinzip und zur Art und Weise wie die Prozessoptimierung als Instrument der Qualitätsentwicklung in der Praxis einer Sozialen Institution angewendet werden kann. 

In einem ersten Schritt wird die Prozessoptimierung als Instrument der Qualitätsentwicklung theoretisch eingeordnet. Im zweiten Teil wird die Durchführung der Optimierung des Prozesses «Kontaktaufnahme/Intake» als Teilprozess des Kernprozesses Beratung beschrieben. Zum Schluss werden Folgerungen in Bezug auf die Erfahrungen mit dem Instrument der Prozessoptimierung sowie der Qualitätsentwicklung innerhalb der Institution gezogen. 

Die Arbeit ist praxisorientiert. Der Blick auf den Arbeitsalltag einer Sozialen Institution ist zentral. Der «Gewinn» in Form von Qualitätsverbesserung einzelner Arbeitsschritte steht im Mittelpunkt. Die Aufarbeitung der Theorie dient als Voraussetzung, um dieses Ziel zu erreichen.
DS_10.1177_0022034519831931 – Supplemental material for MMP-8-Responsive Polyethylene Glycol Hydrogel for Intraoral Drug Delivery
Creators: name: J. Guo
name: H. Sun
name: W. Lei
name: Y. Tang
name: S. Hong
name: H. Yang
name: F.R. Tay
name: C. Huang
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine
subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, DS_10.1177_0022034519831931 for MMP-8-Responsive Polyethylene Glycol Hydrogel for Intraoral Drug Delivery by J. Guo, H. Sun, W. Lei, Y. Tang, S. Hong, H. Yang, F.R. Tay and C. Huang in Journal of Dental Research
Additional file 1 of Heme biosensor-guided in vivo pathway optimization and directed evolution for efficient biosynthesis of heme
Creators: name: Zhang, Jian
name: Li, Qingbin
name: Wang, Qi
name: Zhao, Jingyu
name: Zhu, Yuan
name: Su, Tianyuan
name: Qi, Qingsheng
name: Wang, Qian
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Computational Biology

description: Additional file 1: Table S1. Bacterial strains used in this study.
Additional file 2 of Heme biosensor-guided in vivo pathway optimization and directed evolution for efficient biosynthesis of heme
Creators: name: Zhang, Jian
name: Li, Qingbin
name: Wang, Qi
name: Zhao, Jingyu
name: Zhu, Yuan
name: Su, Tianyuan
name: Qi, Qingsheng
name: Wang, Qian
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Computational Biology

description: Additional file 2: Table S2. Plasmids used in this study.
Qualitative Analyse der Strukturen zur redaktionellen Qualitätssicherung im privaten Rundfunk in der Schweiz 2006
Creators: name: Wyss, Vinzenz
Publisher: name: ZHAW Zürcher Hochschule für Angewandte Wissenschaften
Year: 2007
Subjects: Qualitätssicherung
Journalismus
Qualitätsmanagement
Medienregulierung
Media Regulation
Journalism
Quality Assurance
Quality Management
070: Nachrichtenmedien, Journalismus und Verlagswesen

description: The study gives a quick overview with reference to the corresponding literature of the main requirements of "Media Quality Management”. We describe the main principles of a quality management system for media organizations. In Switzerland the media regulation and supervisory authority – the Federal Office of Communication (OFCOM) – has applied the co-regulation concept by linking the guaranteeing of broadcasting licenses to the implementation of quality management systems within the media organization. We discuss in this context the results of a study commissioned by the OFCOM that shows the state of quality control practices among Swiss private broadcasting organizations and the conclusions drawn by the OFCOM for the broadcasting licensing and regulation process.
description: Qualitätsansprüche und Mechanismen der Qualitätssicherung sind in Schweizer Radio- und TV-Stationen ein Thema, sie werden aber nicht systematisch behandelt. Dies ergab eine medienwissenschaftliche Studien, die das Bundesamt für Kommunikation dem IAM in Auftrag gegeben hat.

Vinzenz Wyss und sein IAM Forschungsteam haben Mechanismen und Praxis der Qualitätssicherung in elf exemplarisch ausgewählten Radio- und Fernsehstationen der drei Sprachregionen untersucht. Strukturen der Qualitätssicherung (z.B. Sendungsplanung, Sendungskritik, Dokumente wie publizistische Leitbilder, Redaktionsstatute) sind zwar bei vielen Sendern vorhanden, eine kontinuierliche Qualitätssicherung findet indes kaum statt. Die Ergebnisse dieser Studie dient dem Bundesamt für Kommunikation bei der Formulierung der Leistungsaufträge im Rahmen der Neukonzessionierung der privaten Radio- und Fernsehstationen. Nach Inkrafttreten des neuen Radio- und Fernsehgesetzes werden die Konzessionen für Privatradios, die über UKW verbreitet werden, sowie die die Konzessionen für Privatfernsehen mit Gebührenanteile neu ausgeschrieben.
description: The study gives a quick overview with reference to the corresponding literature of the main requirements of "Media Quality Management”. We describe the main principles of a quality management system for media organizations. In Switzerland the media regulation and supervisory authority – the Federal Office of Communication (OFCOM) – has applied the co-regulation concept by linking the guaranteeing of broadcasting licenses to the implementation of quality management systems within the media organization. We discuss in this context the results of a study commissioned by the OFCOM that shows the state of quality control practices among Swiss private broadcasting organizations and the conclusions drawn by the OFCOM for the broadcasting licensing and regulation process.
Additional file 1 of Targeting neutrophils extracellular traps (NETs) reduces multiple organ injury in a COVID-19 mouse model
Creators: name: Veras, Flavio P.
name: Gomes, Giovanni F.
name: Silva, Bruna M. S.
name: Caetité, Diego B.
name: Almeida, Cicero J. L. R.
name: Silva, Camila Meirelles S.
name: Schneider, Ayda H.
name: Corneo, Emily S.
name: Bonilha, Caio S.
name: Batah, Sabrina S.
name: Martins, Ronaldo
name: Arruda, Eurico
name: Fabro, Alexandre T.
name: Alves-Filho, José C.
name: Cunha, Thiago M.
name: Cunha, Fernando Q.
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Figure S1. DNase I treatment does not alter leukocyte accumulation in the lungs of SARS-CoV-2-infected mice. K18-hACE2 mice (n=6) were intranasally (i.n) inoculated with SARS-CoV-2 (2x104 PFU) and treated with DNase I (10mg/kg, s.c) for 5 days. (a) Doublets, debris, and dead cells were first excluded. Leukocytes were identified as CD45+ events among viable cells. (b) Flow cytometry analyses of CD45+ living cells from the lung of K18-hACE2 infected mice treated or not with DNase I. Uninfected was used as control. Table S1. Criteria of clinical sickness score.
Vandellia cirrhosa Valenciennes 1846
Creators: name: Escobar-Camacho, Daniel
name: Valdiviezo-Rivera, Jonathan
name: Carrillo-Moreno, Carolina
name: Argüello, Pablo
name: Swing, Kelly
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Siluriformes
Trichomycteridae
Vandellia
Vandellia cirrhosa

description: Vandellia cirrhosa Valenciennes 1846
Distribution
Widespread Amazonia.
Notes
Barriga (2011).
description: Published as part of Escobar-Camacho, Daniel, Valdiviezo-Rivera, Jonathan, Carrillo-Moreno, Carolina, Argüello, Pablo & Swing, Kelly, 2025, Exceptional concentration of fish diversity in Yasuní National Park, Ecuador (Napo River Basin), pp. e 136476 in Biodiversity Data Journal 13 on page e136476, DOI: 10.3897/BDJ.13.e136476
Report on the developed indicators for nowcasting stock migration by Twitter data (Deliverable 5.1)
Creators: name: Sirbu, A.
name: Pollacci, L.
name: Kim, J.
name: Rossetti, G.
Publisher: name: Zenodo
Year: 2021

description: Given the gaps and limitations of traditional data for migration research, social big data have been proposed to complement existing analyses. Amongst various types of social media data, user-generated content from Twitter is considered a valuable resource in migration studies. As recent works have shown, Twitter can indeed be used to study various migration-related problems such as estimating migration flowsor studying language mobility. However, it is still unclear up to which extent these data can be useful. Here we investigate three different approaches to understand migrant stocks based on Twitter. We show that, although data can be reduced, some information can be extracted, and further analyses beyond stocks can be performed. At the same time, we show that in some situations Twitter data is limited and cannot bring a lot of information. In this case complementary data is required.
ONLINE_SUPPLEMENT – Supplemental material for Outcome, efficacy and safety of endovascular thrombectomy in ischaemic stroke according to time to reperfusion: data from a multicentre registry
Creators: name: Meinel, Thomas Raphael
name: Kaesmacher, Johannes
name: Mordasini, Pasquale
name: Mosimann, Pascal J.
name: Jung, Simon
name: Arnold, Marcel
name: Heldner, Mirjam Rachel
name: Michel, Patrik
name: Hajdu, Steven D.
name: Ribo, Marc
name: Requena, Manuel
name: Maegerlein, Christian
name: Friedrich, Benjamin
name: Costalat, Vincent
name: Benali, Amel
name: Pierot, Laurent
name: Gawlitza, Matthias
name: Schaafsma, Joanna
name: Vitor Mendes Pereira
name: Gralla, Jan
name: Fischer, Urs
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified

description: Supplemental material, ONLINE_SUPPLEMENT for Outcome, efficacy and safety of endovascular thrombectomy in ischaemic stroke according to time to reperfusion: data from a multicentre registry by Thomas Raphael Meinel, Johannes Kaesmacher, Pasquale Mordasini, Pascal J. Mosimann, Simon Jung, Marcel Arnold, Mirjam Rachel Heldner, Patrik Michel, Steven D. Hajdu, Marc Ribo, Manuel Requena, Christian Maegerlein, Benjamin Friedrich, Vincent Costalat, Amel Benali, Laurent Pierot, Matthias Gawlitza, Joanna Schaafsma, Vitor Mendes Pereira, Jan Gralla and Urs Fischer in Therapeutic Advances in Neurological Disorders
Brochis ambiacus
Creators: name: Escobar-Camacho, Daniel
name: Valdiviezo-Rivera, Jonathan
name: Carrillo-Moreno, Carolina
name: Argüello, Pablo
name: Swing, Kelly
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Siluriformes
Callichthyidae
Brochis
Brochis ambiacus

description: Brochis ambiacus (Cope 1872)
Distribution
Upper Amazon
Notes
Barriga (1994), Guarderas and Jácome-Negrete (2013).
description: Published as part of Escobar-Camacho, Daniel, Valdiviezo-Rivera, Jonathan, Carrillo-Moreno, Carolina, Argüello, Pablo & Swing, Kelly, 2025, Exceptional concentration of fish diversity in Yasuní National Park, Ecuador (Napo River Basin), pp. e 136476 in Biodiversity Data Journal 13 on page e136476, DOI: 10.3897/BDJ.13.e136476
AUT831487_Supplemental_table_3 – Supplemental material for Assuming ability of youth with autism: Synthesis of methods capturing the first-person perspectives of children and youth with disabilities
Creators: name: Rackeb Tesfaye
name: Courchesne, Valerie
name: Afiqah Yusuf
name: Savion-Lemieux, Tal
name: Singh, Ilina
name: Shikako-Thomas, Keiko
name: Mirenda, Pat
name: Waddell, Charlotte
name: Smith, Isabel M
name: Nicholas, David
name: Szatmari, Peter
name: Bennett, Terry
name: Duku, Eric
name: Georgiades, Stelios
name: Kerns, Connor
name: Vaillancourt, Tracy
name: Zaidman-Zait, Anat
name: Zwaigenbaum, Lonnie
name: Mayada Elsabbagh
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: Education
subject: 130312 Special Education and Disability
subject: FOS: Educational sciences

description: Supplemental material, AUT831487_Supplemental_table_3 for Assuming ability of youth with autism: Synthesis of methods capturing the first-person perspectives of children and youth with disabilities by Rackeb Tesfaye, Valerie Courchesne, Afiqah Yusuf, Tal Savion-Lemieux, Ilina Singh, Keiko Shikako-Thomas, Pat Mirenda, Charlotte Waddell, Isabel M Smith, David Nicholas, Peter Szatmari, Terry Bennett, Eric Duku, Stelios Georgiades, Connor Kerns, Tracy Vaillancourt, Anat Zaidman-Zait, Lonnie Zwaigenbaum and Mayada Elsabbagh in Autism
Supplementary_Figure_clp – Supplemental material for C-Reactive Protein and Ferritin Are Associated With Organ Dysfunction and Mortality in Hospitalized Children
Creators: name: Horvat, Christopher M.
name: Bell, Jamie
name: Sajel Kantawala
name: Au, Alicia K.
name: Clark, Robert S. B.
name: Carcillo, Joseph A.
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 111403 Paediatrics
subject: FOS: Clinical medicine

description: Supplemental material, Supplementary_Figure_clp for C-Reactive Protein and Ferritin Are Associated With Organ Dysfunction and Mortality in Hospitalized Children by Christopher M. Horvat, Jamie Bell, Sajel Kantawala, Alicia K. Au, Robert S. B. Clark and Joseph A. Carcillo in Clinical Pediatrics
Brochis arcuatus
Creators: name: Escobar-Camacho, Daniel
name: Valdiviezo-Rivera, Jonathan
name: Carrillo-Moreno, Carolina
name: Argüello, Pablo
name: Swing, Kelly
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Siluriformes
Callichthyidae
Brochis
Brochis arcuatus

description: Brochis arcuatus (Elwin 1938)
Distribution
South America: Upper Amazon River Basin.
description: Published as part of Escobar-Camacho, Daniel, Valdiviezo-Rivera, Jonathan, Carrillo-Moreno, Carolina, Argüello, Pablo & Swing, Kelly, 2025, Exceptional concentration of fish diversity in Yasuní National Park, Ecuador (Napo River Basin), pp. e 136476 in Biodiversity Data Journal 13 on page e136476, DOI: 10.3897/BDJ.13.e136476
ПАТОПСИХОЛОГИЧЕСКИЕ ОСОБЕННОСТИ КОМОРБИДНОГО АЛКОГОЛИЗМА И ШИЗОАФФЕКТИВНЫХ РАССТРОЙСТВ
Creators: name: Абдуразакова, Робия
Publisher: name: Zenodo
Year: 2024

description: Исследователи подчеркивают тесную взаимосвязь факторов, определяющих возникновение и развитие психических заболеваний у лиц с сопутствующими формами расстройств, связанных с употреблением наркотиков. Между тем, сочетание алкогольной зависимости с шизофренией способствует увеличению числа общественно опасных деяний.
Supple_tables – Supplemental material for Development of an Assessment Scale for Commencing Home-Visit Nursing in Japan: Examining the Construct
Creators: name: Shimohigoshi, Naoko
name: Yatsushiro, Rika
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111099 Nursing not elsewhere classified
subject: 111702 Aged Health Care
subject: 111799 Public Health and Health Services not elsewhere classified

description: Supplemental material, Supple_tables for Development of an Assessment Scale for Commencing Home-Visit Nursing in Japan: Examining the Construct by Naoko Shimohigoshi and Rika Yatsushiro in Home Health Care Management & Practice
Hedgegate Swiss FoHF Indizes
Creators: name: Dürr, Franziskus
name: Meier, Peter
name: Ruckstuhl, Andreas
Publisher: name: ZHAW Zürcher Hochschule für Angewandte Wissenschaften
Year: 2008
Subjects: Hedge Funds
Hedgegate
Sfohfi
Swiss Fohf
332: Finanzwirtschaft

description: Supported by the Transparency Council Funds of Hedge Funds, Zurich University of Applied Sciences has developed an index ‘family’ for Swiss funds of hedge funds (hedgegate Swiss FoHF Indices), thus setting a new standard in the hedge funds industry. For the first time, these indices are based on a universe of funds defined by the authorities and as such avoid the usual bias. Moreover, the hedgegate Swiss Fund of Hedge Fund Indices are available in Swiss francs, the US dollar and the euro and are calculated in the respective currencies.
description: Die ZHAW entwickelte mit Unterstützung des Transparency Council Funds of Hedge Funds eine Indexfamilie für Schweizer Dach-Hedgefonds und setzt damit einen neuen Standard in der Hedge-Fondsindustrie. Erstmals basieren solche Indices auf einem von Behörden definierten Fondsuniversum und vermeiden dadurch übliche Verzerrungen aufgrund der Fondsauswahl. Die SFoHFI (hedgegate Swiss Fund of Hedge Fund Indices) sind zudem für den Schweizerfranken, den US-Dollar und den Euro verfügbar und werden aufgrund der jeweiligen originären Währungsanteile ermittelt.
description: Supported by the Transparency Council Funds of Hedge Funds, Zurich University of Applied Sciences has developed an index ‘family’ for Swiss funds of hedge funds (hedgegate Swiss FoHF Indices), thus setting a new standard in the hedge funds industry. For the first time, these indices are based on a universe of funds defined by the authorities and as such avoid the usual bias. Moreover, the hedgegate Swiss Fund of Hedge Fund Indices are available in Swiss francs, the US dollar and the euro and are calculated in the respective currencies.
Supplemental_Table_S1 – Supplemental material for Predictors of Hand Function Following Digit Replantation: Quantitative Review and Meta-Analysis
Creators: name: Ashkaun Shaterian
name: Lohrasb Ross Sayadi
name: Tiourin, Ekaterina
name: Gardner, Daniel J.
name: Evans, Gregory R. D.
name: Leis, Amber
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: Medicine
subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences

description: Supplemental material, Supplemental_Table_S1 for Predictors of Hand Function Following Digit Replantation: Quantitative Review and Meta-Analysis by Ashkaun Shaterian, Lohrasb Ross Sayadi, Ekaterina Tiourin, Daniel J. Gardner, Gregory R. D. Evans and Amber Leis in HAND
Supplemental Material, LHW_Post-training_Quiz - Testing the Effectiveness of Implementing a Model of Mental Healthcare Involving Trained Lay Health Workers in Treating Major Mental Disorders Among Youth in a Conflict-Ridden, Low-Middle Income Environment: Part II Results
Creators: name: Malla, Ashok
name: Margoob, Mushtaq
name: Srividya Iyer
name: Majid, Abdul
name: Lal, Shalini
name: Joober, Ridha
name: Mansouri, Bilal Issaoui
Publisher: name: SAGE Journals
Year: 2019
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine

description: Supplemental Material, LHW_Post-training_Quiz for Testing the Effectiveness of Implementing a Model of Mental Healthcare Involving Trained Lay Health Workers in Treating Major Mental Disorders Among Youth in a Conflict-Ridden, Low-Middle Income Environment: Part II Results by Ashok Malla, Mushtaq Margoob, Srividya Iyer, Abdul Majid, Shalini Lal, Ridha Joober, and Bilal Issaoui Mansouri in The Canadian Journal of Psychiatry
Brochis leopardus
Creators: name: Escobar-Camacho, Daniel
name: Valdiviezo-Rivera, Jonathan
name: Carrillo-Moreno, Carolina
name: Argüello, Pablo
name: Swing, Kelly
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Siluriformes
Callichthyidae
Brochis
Brochis leopardus

description: Brochis leopardus (Myers 1933)
Distribution
Western Amazonia.
description: Published as part of Escobar-Camacho, Daniel, Valdiviezo-Rivera, Jonathan, Carrillo-Moreno, Carolina, Argüello, Pablo & Swing, Kelly, 2025, Exceptional concentration of fish diversity in Yasuní National Park, Ecuador (Napo River Basin), pp. e 136476 in Biodiversity Data Journal 13 on page e136476, DOI: 10.3897/BDJ.13.e136476
title: Die deutsche evangelische Auslandsarbeit 1922–1934 unter wechselnden politischen Rahmenbedingungen im europäischen Kontext - Leitlinien, Konzeptionen und Konkretionen
Creators: name: Reiff, Julia Stefanie
Publisher: name: Tübingen Library Publishing
Year: 2024
Subjects: subject: Deutsch , Ausland , Auslandsarbeit , Weimarer Republik , Diaspora , Diaspora
subject: 230
subject: evangelisch
subject: Protestant
subject: Auslandsgemeinde
subject: German
subject: Kirchenbund

description: Bereits im 16. Jahrhundert formierten sich erste deutsche evangelische Auslandsgemeinden in den Haupt- und Handelsstädten Europas. Nach Ende des Ersten Weltkrieges 1918 bedeutete die staatlich proklamierte Trennung von Landeskirchen und staatlichen Institutionen in Deutschland auch hier einen Einschnitt. Der Deutsche Evangelische Kirchenbund formulierte deshalb 1922 die weltweite deutsche evangelische Auslandsarbeit erstmals als landeskirchliche Gesamtaufgabe. Die Arbeit zeigt, dass die deutschen evangelischen Auslandsgemeinden in den Hauptstädten der ehemaligen Kriegsgegner London, Rom und Paris die aus Berlin vorgelegten Leitlinien und Konzeptionen in den Folgejahren verschieden konkretisierten. Konfessionelle und nationale Faktoren waren hierbei mit unterschiedlicher Schwerpunktsetzung auf allen Ebenen prägend. 1934 setzt mit der Gründung des Kirchlichen Amtes für auswärtige Angelegenheiten der Deutschen Evangelischen Kirche die Einordnung in eine neue institutionelle Phase ein.
Bedürfnisse von Frauen mit Migrationshintergrund in der Schweiz während Schwangerschaft, Geburt und Wochenbett
Creators: name: Widmer, Laura
Publisher: name: ZHAW Zürcher Hochschule für Angewandte Wissenschaften
Year: 2015
Subjects: Migration
Migrantinnen
Geburtshilfe
Schweiz
Bedürfnisse
618: Geburtsmedizin und Hebammenarbeit

description: Darstellung des Themas: Unterschiedliche Studien haben aufgezeigt, dass Migrantinnen in der Schweiz ihr Gesundheitspotential im Bereich der reproduktiven Gesundheit nicht ausschöpfen können und im Vergleich zur einheimischen Bevölkerung einen schlechteren Gesundheitszustand aufweisen.
Ziel: Ziel der Arbeit ist es, die in der Literatur beschriebenen Bedürfnisse der Migrantinnen während Schwangerschaft, Geburt und Wochenbett darzustellen. Daraus soll abgeleitet werden, wie der Zugang von Migrantinnen zum geburtshilflichen System optimiert werden kann.
Methode: Es wurden drei Datenbanken anhand festgelegter Keywords nach themenrelevanter Literatur durchsucht. Des Weiteren wurde auf der Homepage des Bundesamtes für Migration, des Bundesamt für Gesundheit und des Roten Kreuzes nach weiteren Studien recherchiert. Ferner wurden vier Studien unter Berücksichtigung definierter Ein- und Ausschlusskriterien ausgewählt und bewertet.
Relevante Ergebnisse: Migrantinnen sind eine heterogene Gruppe und die Suche nach einer einheitlichen Lösung zur Anpassung von Dienstleistungen ist nicht Erfolg versprechend. Es lassen sich dennoch Anhaltspunkte zu Problemfeldern und Tendenzen zu gemeinsamen Bedürfnissen ableiten.
SchlussfolgerungenAufgrund der hohen gesellschaftlichen Akzeptanz und Vertrauenswürdigkeit von Hebammen, fällt ihnen bei der Verbesserung der informellen Transparenz bezüglich des medizinischen Angebotes eine grosse Bedeutung zu. In der Betreuung von Migrantinnen soll weniger das Herkunftsland, sondern vielmehr das Individuum mit seiner persönlichen Lebensgeschichte und individuellen Lebenswelt im Fokus stehen.
title: Antimicrobials from the Human Microbiome as well as Plasma Based Mass Spectrometry of Living Cells
Creators: name: Schäfle, Timm
Publisher: name: Universität Tübingen
Year: 2026
Subjects: subject: 500
subject: 540
subject: Chemie
subject: Synthese
subject: Synthesis
subject: Analytics
subject: Analytik
subject: cold Plasma
subject: kaltes Plasma
subject: Ion Source
subject: Ionenquelle
subject: Massenspektrometrie
subject: Mass Spectrometry
subject: Micrococcin P1
subject: Pulcherriminsäure
subject: Micrococcin P1
subject: Bacteria
subject: Bakterien
subject: Antimicrobials
subject: Chemistry
subject: Antimikrobielle Wirkstoffe

description: Dissertation gesperrt bis 04.12.2026
description: Without effective preventive measures, antimicrobial resistance is projected to become the leading cause of death by 2050, resulting in an estimated 10 million deaths annually. Addressing this existential crisis necessitates the development of novel antimicrobial compounds and innovative analytical tools for their identification. This thesis investigates the total synthesis of the antimicrobial siderophore pulcherriminic acid, which is characterized by a cyclo-dileucine core unit featuring two hydroxamic acids symmetrically positioned within its ring structure. However, the synthetic process did not yield pulcherriminic acid as intended. Instead, two biologically inactive derivatives were produced. These derivatives, despite their structural similarity to pulcherriminic acid, exhibit a shift in the position of core protons due to in situ complexation with sodium. In addition, novel derivatives of micrococcin P1, the first discovered thiopeptide, were identified during biological investigations of nasal isolates from the human microbiome. Using a combination of high-performance liquid chromatography (HPLC), nuclear magnetic resonance (NMR) spectroscopy, and precursor feeding experiments with labeled threonine, the chemical structures of three previously unknown derivatives were elucidated. The structural analysis revealed depsipeptide-like configurations in all derivatives, marking the first recorded depsipeptide originating from ribosomal biosynthesis. Notably, the loss of antimicrobial activity in these derivatives underscores the critical role of the 2,3-didehydrobutyrine residue. Furthermore, this thesis describes the development of a novel ion source for mass spectrometry, utilizing low-temperature plasma. This innovation enables the analysis of living microorganisms, such as bacteria, without causing damage. The ion source facilitates multiple analyses of the same living sample, allowing for real-time mass spectrometric monitoring of bacterial growth phases and molecular-level changes over time. Additional capabilities include the in-situ derivatization of analytes and the in-situ separation of molecules under varying pressure gradients.