cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Functional adaptation of bone: interactive effects of diet and mechanical loading environment
Creators: name: Lorincz, Caeley Rae
Publisher: name: Kinesiology
Year: 2009

description: Bibliography: p. 158-176
description: Nutritional status and physical loading remain two of the most influential modifiable risk factors in the development of osteopenia and osteoporosis. Creating optimal dietary and mechanical loading environments during the susceptible period surrounding development should encourage establishment of peak bone mass and may attenuate bone-related fragility fractures later in life. These studies were designed to investigate the interrelations between a diet previously denoted as deleterious for skeletal integrity (i.e., high saturated fat and sucrose (HFS)) and exogenous loading regimes previously deemed osteogenic. A cantilever loading device was used to apply non­invasive loads 5d/wk for 3wk to the tibiae of skeletally immature female C57BL/6 mice consuming either low-fat complex carbohydrate (LFCC) or HFS diets. Upon completion of the intervention, half the tibiae from each diet cohort were scanned using micro­computed tomography and tested for structural integrity by three-point bending. Expression of RANKL, OPG, COX-2, PPAR-y, and Cathepsin-K mRNA were measured in the other half of tibiae. Serum markers of bone formation ( osteocalcin) and markers of bone resorption (i.e., tartrate resistant acid phosphatase) were measured in cardiac blood. Mice fed an HFS diet were significantly heavier and fatter than LFCC mice. After normalizing for differences in body mass, HFS mice had compromised tibial structural and geometrical parameters, as well as elevated serum markers of bone resorption. RANKL mRNA was significantly elevated, and COX-2 mRNA tended to be elevated in this cohort, suggesting bone loss associated with the chronic inflammatory state of diet­induced obesity. High-magnitude, low-frequency loading did not benefit mice fed a LFCC diet, but did improve structural and geometrical properties in mice fed the HFS diet. When brief rest-periods ( ?? 1 s) were interspersed with the high-frequency loading regime (30 Hz), however, both groups showed positive skeletal adaptation. Adaptation observed in the LFCC cohort was primarily structural, while changes in the HFS cohort were principally geometrical. The reasons for this difference have yet to be elucidated. These data emphasize the complex interrelations between diet and external loading environments on bone health during periods of growth, and highlight the potential for osteogenic loading regimes for individuals with varied nutritional status.
The role of tyrosines in bacterial iron acquisition by periplasmic ferric binding proteins
Creators: name: Khambati, Husain K.
Publisher: name: University of Calgary
Year: 2009

description: Bibliography: p. 120-133
description: Many pages are in colour.
description: The human host-specific Gram-negative human pathogen H. influenzae and the porcine pathogen A. pleuropneumoniae can utilize transferrin as their main source of iron for growth. A surface receptor complex made of transferrin binding proteins (TbpA and TbpB) facilitate the release of iron from host transferrin into the periplasm, where it is, in turn, sequestered by a periplasmic iron binding protein. In H. influenzae, this protein is called ferric binding protein A (FbpA). The iron coordination site of FbpA is analogous to that of transferrin and lactoferrin, giving it the term, bacterial transferrin. The results from structural and functional studies in this thesis support a model in which the initial step in iron binding is mediated by a pair of adjacent tyrosines on the C-terminal domain of FbpA. A series of site-directed mutants of the adjacent tyrosine residues show abrogation of iron binding ability in in vitro binding studies and a severe defect in iron transport in a reconstituted H. influenzae FbpABC pathway in E. coli; this is in support of prior evidence discovered for host glycoproteins transferrin and lactoferrin. Collectively these results demonstrate that the presence of a twin-tyrosine motif common to many periplasmic iron binding proteins is critical for initially capturing the ferric iron released by the outer membrane receptor complex. Also characterized in this thesis is periplasmic protein AfuA, identified previously as a functional homologue of FbpA. Sequence analysis and in vitro binding assays demonstrate, however, that AfuA is not a true FbpA homologue, but rather may represent a novel class of ferrous binding proteins. A reconstituted afuABC operon in a specialized iron-deficient strain of E. coli was found to be capable of periplasm-to-cytoplasm iron transport.
Bayesian estimation of a discrete response model with double rules of sample selection
Creators: name: Zhang, Rong
name: Inder, Brett A.
name: Zhang, Xibin
Publisher: name: Monash University
Year: 2022
Subjects: classificationCode: 380202
subject: Econometric and statistical methods
classificationCode: 380299
subject: Econometrics not elsewhere classified

description: We present a Bayesian sampling algorithm for parameter estimation in a discrete-response model, where the dependent variables contain two layers of binary choices and one ordered response. Our investigation is motivated by an empirical study using such a double-selection rule for three labour-market outcomes, namely labour-force participation, employment and occupational skill level. It is of particular interest to measure the marginal effects of some mental health factors on these labour-market outcomes. The contribution of our investigation is to present a sampling algorithm, which is a hybrid of Gibbs and Metropolis-Hastings algorithms. In Monte Carlo simulations, numerical maximization of likelihood fails to converge for more than half of the simulated samples. Our Bayesian method represents a substantial improvement: it converges in every sample, and performs with similar or better precision than maximum likelihood. We apply our sampling algorithm to the double-selection model of labour-force participation, employment and occupational skill level, where marginal effects of explanatory variables, in particular the mental health factors, on the three labour-force outcomes are assessed through 95% Bayesian credible intervals. The proposed sampling algorithm can easily be modified for other multivariate nonlinear models that involve selectivity and are difficult to estimate by other means.
The role of endogenous proteinase-activated receptor-2 (par2) during the development of intestinal inflammation
Creators: name: Hyun, Eric
Publisher: name: University of Calgary
Year: 2009

description: Bibliography: p. 206-244
description: Some pages are in colour.
description: Proteinase-activated receptor-2 (P AR2) has been shown to mediate various physiological functions of the gut. However, the exact role of P AR2 in the process of intestinal inflammation is unclear. Thus, we aimed at addressing the role of P AR2 during the development of experimental colitis. We challenged P AR2-deficient (P AR2 -/-) or wildtype (WT) mice with trinitrobenzene sulphonic acid (TNBS), dextran sodium sulphate (DSS) or oxazolone to induce experimental colitis. In three different models of colitis, PAR2 _,_ mice showed a reduction in leukocyte adherence along the colonic venules, macroscopic damages, myeloperoxidase activity, and bowel thickness as compared to WT mice. In TNBS challenged colons of PAR2 -/- mice, the expression of adhesion molecules (ICAM-1, VCAM-1, and alpha-4) was reduced whereas the expression of both cyclooxygenase-1 and -2 was increased as compared to WT mice. Next, we assessed the effects of daily administration of PAR2-AP (intracolonically) or a novel PAR2 antagonist (ENMD-1005, intraperitoneally) after DSS or TNBS challenge. None of these treatments modulated the development of colitis. ENMD-1OO5 also failed to prevent PAR2-AP-induced paw edema. We next generated chimeric mice (via bone marrow transplant) using PAR2 -/­and WT mice in order to assess the role of PAR2 expressed on the bone marrow derived cells during the development of colitis. PAR2 -/- chimeric mice, irrespective of the source of injected bone marrow cells showed a reduction in inflammatory parameters after DSS or TNBS challenge. The ability of leukocyte stimuli to induce leukocyte trafficking in P AR2 mice was also assessed. Increase in leukocyte adherence induced by ischemia/reperfusion, fMLP, or TNF-a, but not PAF, was reduced in PAR2 -/- mice as compared to WT mice. No difference in the expression of TNF-a receptor-! was observed between naive PAR2 -/- and WT mice. Lastly, incubation of endothelial cells with TNF-a (as early as 1 hour) increased the trypsin-like activity in the cell supematants, suggesting TNF-a may induce the release of potential P AR2 activating proteinases. Taken together, we conclude that PAR2 plays a pro-inflammatory role in the intestine and represents a potential therapeutic target for the treatment of inflammatory bowel disease.
Serotonergic modulation of locomotor networks
Creators: name: Dunbar, Mary Jansen
Publisher: name: University of Calgary
Year: 2009

description: Bibliography: p. 163-177
description: A few pages are in colour.
description: Serotonin can potently activate and modulate spinal locomotor circuits in a variety of species. Many of these findings have been obtained by applying serotonin exogenously to the isolated spinal cord of in vitro preparations, which has the drawback of indiscriminately activating extrasynaptic receptors and neurons. To investigate the role of endogenously released serotonin in modulating locomotor networks the selective serotonin reuptake inhibitor citalopram was used. The addition of 20 ÂµM of citalopram caudal to thoracic segment 5 (T5) had an overall inhibitory effect on the lumbar CPG. When citalopram was added in the presence of 5-HT1A and 5-HT18 antagonists the inhibitory effects were reversed. The remaining excitatory effects were mediated by 5-HT7 and 5-HT2 receptors. Overall these data lead us to suggest that endogenously released 5-HT plays a crucial role in eliciting and modulating locomotor activity during early neonatal development.
Un precursore dell'ambientalismo nell'Italia dell'Ottocento. Il geografo americano George Perkins Marsh
Creators: name: Marchi, Marzia
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2019
Subjects: M-GGR/01 Geografia

description: A forerunner of conservation in nineteenth century Italy.
The American geographer George Perkins Marsh 

 	The article investigate on the geographer George Perkins Marsh and its relations with Italian culture during the second half of the nineteenth century, when he lived in newly unified Italy as American ambassador. Marsh  is a pioneer in denouncing  the huge human impact on the Earth and in claim for nature conservation. He influenced the Italian debate on agricultural impact of forests and river assets, but was also influenced by Italian and Mediterranean history of environment degradation. Marsh was a real global thinker, because looking to land degradation on the Old World, he worked to nature preservation in the New World. The attention to this author, therefore, allows us to observe the awareness of environmental problems in Italy, and the necessary conservation  actions to be taken in that time.
АНАТОМИЯ КЛАПАНОВ СЕРДЦА   Патология
Creators: name: Хидиров Акрам Муминжонович  студент Ташкентский государственный стоматологический  институт (ТГСИ) Министерство здравоохранения Республики Узбекистан г.Ташкент
name: Научный руководитель:Хайдарова Барно Исраилжановна Старший преподаватель кафедры анатомии Ташкентский государственный стоматологический институт (ТГСИ) Министерство здравоохранения республики Узбекистан г.Ташкент
Publisher: name: Zenodo
Year: 2023

description: В полости сердца принято различать атриовентрикулярные клапаны, расположенные между предсердиями и желудочками, и артериальные клапаны, находящиеся на границе между желудочками и магистральными артериями (легочной артерией и аортой). Долгое время считалось, что клапаны сердца являются механическими копиями эндокарда. Сегодня, благодаря всесторонним исследованиям, появилась возможность рассматривать клапаны сердца как органогенные образования. Нейронные структуры, расположенные в заслонках предсердного и желудочкового клапанов, вместе с мышечными волокнами получают сосудистое питание преимущественно из основания заслонки и регулируют работу клапанов сердца синхронно с фазой сердечной деятельности, добиваясь конгруэнтной поверхности закрытия. В артериальных клапанах сосуды менее выражены, чем в атриовентрикулярных. Вблизи основания полулунной заслонки сосуды сопровождаются пучками миокардиальных волокон, которые могут способствовать натяжению полулунной заслонки и обеспечивать конгруэнтность замыкательных поверхностей
Ultraviolet Spectroscopy of Rapidly-Rotating Solar-Mass Stars: Emission Line Redshifts as a Test of the Solar-Stellar Connection
Creators: name: Linsky, Jeffrey L.
name: Bushinsky, Rachel
name: Ayres, Tom
name: France, Kevin
Publisher: name: arXiv
Year: 2012
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We compare high-resolution ultraviolet spectra of the Sun and thirteen solarmass main sequence stars with different rotational periods that serve as proxies for their different ages and magnetic field structures. In this the second paper in the series, we study the dependence of ultraviolet emission-line centroid velocities on stellar rotation period, as rotation rates decrease from that of the Pleiades star HII314 (Prot = 1.47 days) to Alpha Cen A (Prot = 28 days). Our stellar sample of F9 V to G5 V stars consists of six stars observed with the Cosmic Origins 1Guest Observer, NASA/ESA Hubble Space Telescope and User of the Data Archive at the Space Telescope Science Institute. Spectrograph on HST and eight stars observed with the Space Telescope Imaging Spectrograph on HST. We find a systematic trend of increasing redshift with more rapid rotation (decreasing rotation period) that is similar to the increase in line red shift between quiet and plage regions on the Sun. The fastest-rotating solar-mass star in our study, HII314, shows significantly enhanced redshifts at all temperatures above log T = 4.6, including the corona, which is very different from the redshift pattern observed in the more slowly-rotating stars. This difference in the redshift pattern suggests that a qualitative change in the magnetic-heating process occurs near Prot = 2 days. We propose that HII314 is an example of a solar-mass star with a magnetic heating rate too large for the physical processes responsible for the redshift pattern to operate in the same way as for the more slowly rotating stars. HII314 may therefore lie above the high activity end of the set of solar-like phenomena that is often called the "solar-stellar connection".
description: 36 pages, 7 figures, 6 tables, to appear in the Astrophysical Journal July 2012
Orbital perturbations due to massive rings
Creators: name: Iorio, Lorenzo
Publisher: name: arXiv
Year: 2012
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: We analytically work out the long-term orbital perturbations induced by a homogeneous circular ring of radius Rr and mass mr on the motion of a test particle in the cases (I): r > R_r and (II): r < R_r. In order to extend the validity of our analysis to the orbital configurations of, e.g., some proposed spacecraftbased mission for fundamental physics like LISA and ASTROD, of possible annuli around the supermassive black hole in Sgr A* coming from tidal disruptions of incoming gas clouds, and to the effect of artificial space debris belts around the Earth, we do not restrict ourselves to the case in which the ring and the orbit of the perturbed particle lie just in the same plane. From the corrections to the standard secular perihelion precessions, recently determined by a team of astronomers for some planets of the Solar System, we infer upper bounds on mr for various putative and known annular matter distributions of natural origin (close circumsolar ring with R_r = 0.02-0.13 au, dust ring with R_r = 1 au, minor asteroids, Trans-Neptunian Objects). We find m_r <= 1.4 10^-4 m_E (circumsolar ring with R_r = 0.02 au), m_r <= 2.6 10^-6 m_E (circumsolar ring with R_r = 0.13 au), m_r <= 8.8 10^-7 m_E (ring with R_r = 1 au), m_r <= 7.3 10^-12 M_S (asteroidal ring with R_r = 2.80 au), m_r <= 1.1 <= 10^-11 M_S (asteroidal ring with R_r = 3.14 au), m_r <= 2.0 10^-8 M_S (TNOs ring with R_r = 43 au). In principle, our analysis is valid both for baryonic and non-baryonic Dark Matter distributions.
description: LaTex2e, no figures, 2 tables, 35 pages, 225 references. Accepted by Earth, Moon, and Planets. I thank M. Efroimsky for his comments. Minor typos fixed in reference list
title: Virtuelle Bauteilprüfung im Digitalen Zwilling in der Additiven Fertigung
Creators: name: Krückemeier, Slim
Publisher: name: UNSPECIFIED
Year: 2025

description: Die Qualitätssicherung stellt derzeit eine der größten Herausforderungen in der Additiven Fertigung dar. Um den Aufwand zu minimieren und somit die Verbreitung der Additiven Fertigung weiter voranzutreiben, wird in dieser Dissertation ein neuartiger Ansatz zur virtuellen Prüfung der Bauteilqualität mithilfe Digitaler Zwillinge vorgestellt. Das Ziel besteht in der Überführung der bislang manuell durchgeführten Bauteilprüfung in den virtuellen Raum. Dazu wird in der Dissertation die virtuelle Bauteilprüfung auf Basis Digitaler Zwillinge konzipiert und ein Prozess zur Planung der virtuellen Prüfprozesse modelliert. Der Prozess sieht vor, bereits während der Produktentwicklung mithilfe eines Assistenzsystems die während der Additiven Fertigung anzuwendende virtuelle Bauteilprüfung zu planen. Dies umfasst die Ermittlung der Prüfmerkmale, die Auswahl der virtuellen Prüfmethoden und Erstellung der Prüfanweisungen. Für jeden Prozessschritt wird eine Methode entwickelt, welche die Durchführung des Schritts unterstützt. Zudem wird ein Informationsmodell aufgebaut, in dem die benötigten und erzeugten Informationen abgebildet werden.
Das in der Theorie beschriebene Assistenzsystem wird prototypisch implementiert, um eine Validierung des Konzepts anhand einer Fallstudie zu ermöglichen. Als repräsentatives Fallbeispiel wird eine Handgelenkorthese verwendet, welche spezifische Anforderungen an Materialeigenschaften, Maßgenauigkeit und Oberflächenrauheit stellt, deren Erfüllung geprüft werden muss. Der Planungsprozess für die virtuelle Bauteilprüfung der Handgelenkorthese wird mithilfe des Assistenzsystems durchgeführt. Der resultierende virtuelle Prüfplan dient der exemplarischen Umsetzung der virtuellen Bauteilprüfung, wodurch die Machbarkeit der entworfenen Anwendung demonstriert wird. Zu diesem Zweck wird ein Digitaler Zwilling für einen FFF-3D-Drucker implementiert, auf dessen Basis die virtuelle Bauteilprüfung für ein Prüfmerkmal integriert wird.
Die Ergebnisse der Validierung zeigen, dass Digitale Zwillinge den Einsatz virtueller Prüfmethoden zur Nutzung in der virtuellen Bauteilprüfung ermöglichen, der modellierte Planungsprozess zielführend ist und die Planung durch das Assistenzsystem effektiv unterstützt wird. Im Rahmen der Diskussion werden jedoch auch die Limitationen des Ansatzes beleuchtet. Zu nennen sind hier insbesondere der hohe Implementierungsaufwand sowie die den IT-Systemen innewohnenden, potenziellen Sicherheitsrisiken. Abschließend werden zukünftige Forschungspotenziale aufgezeigt. Diese umfassen unter anderem die Optimierung der Prüfmethoden sowie die Anpassung an spezifische Anforderungen verschiedener Industriezweige, wie bspw. der Luftfahrt- oder der Automobilindustrie.
Position paper of the Gesellschaft für Aerosolforschung on understanding the role of aerosol particles in SARS-CoV-2 infection
Creators: name: Gesellschaft Für Aerosolforschung E.V.
Publisher: name: Zenodo
Year: 2020
Subjects: Aerosol, Infection, Filtration, Masks, Face Shields

description: Many studies have already shown that viruses can spread via aerosol particles. An aerosol is a mixture of air with solid or liquid particles dispersed in it. To understand the role of aerosol particles as a transmission path of SARS-CoV-2, knowledge of the different processes in an aerosol is therefore of particular importance. With this paper, GAeF would like to contribute to a better understanding of the term “aerosol” and the relevant aerosol processes. In the context of this paper only the essential basics will be discussed. For a deeper understanding of the partly complex processes, please refer to the literature mentioned at the end of the paper. The paper summarises a large number of studies on the formation of virus-laden aerosol particles and their spread. Based on this, it can be concluded that exhaled aerosol particles may play a prominent role in the spread of viruses in the corona pandemic. Finally, this paper discusses possible measures to reduce the spread of aerosol particles. The measures discussed are based on the current public debate including ventilation, air purifiers, HVAC systems and masks. Advice is given on the correct and sensible use of these measures.
Electronic multicriticality in bilayer graphene
Creators: name: Cvetkovic, Vladimir
name: Throckmorton, Robert E.
name: Vafek, Oskar
Publisher: name: arXiv
Year: 2012
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We map out the possible ordered states in bilayer graphene at the neutrality point by extending the previous renormalization group treatment of many-body instabilities to finite temperature, trigonal warping and externally applied perpendicular electric field. We were able to analytically determine all outcomes of the RG flow equations for the 9 four-fermion coupling constants. While the full phase diagram exhibits a rich structure, we confirm that when forward scattering dominates, the only ordering tendency with divergent susceptibility at finite temperature is the nematic. At finite temperature this result is stable with respect to small back and layer imbalance scattering; further increasing their strength leads to the layer antiferromagnet. We also determine conditions for other ordered states to appear and compare our results to the special cases of attractive and repulsive Hubbard models where exact results are available.
description: 27 pages, 13 figures, 1 table (published version)
On the Impossibility of Informationally Efficient Markets
Creators: name: Stiglitz, Joseph E.
name: Grossman, Sanford J.
Publisher: name: Columbia University
Year: 1980
Subjects: Economics

description: If competitive equilibrium is defined as a situation in which prices are such that all arbitrage profits are eliminated, it is not clear whether it is possible that a competitive economy will always be in equilibrium. Clearly not, for then those who arbitrage make no return from their costly activity. Hence the assumptions that all markets, including that for information, are always in equilibrium and always perfectly arbitraged are inconsistent when arbitrage is costly. A model has been proposed in which there is an equilibrium degree of disequilibrium: prices reflect the information of informed individuals but only partially, so that those who expend resources to obtain information do receive compensation. The model is the simplest one in which prices perform a well-articulated role in conveying information from the informed to the uninformed. When informed individuals observe information that the return to a security is going to be high, they bid its price up, and conversely when they observe information that the return is going to be low. Thus the price system makes publicly available the information obtained by informed individuals to the uniformed. The theory of "efficient capital markets" has also been discussed.
Prävention und Hilfe bei stoffgebundenen und stoffungebundenen Suchterkrankungen in Niedersachsen. Abschlussbericht für das Niedersächsische Ministerium für Soziales, Gesundheit und Gleichstellung
Creators: name: Rehbein, Florian
name: Weber, Jan
name: Kühne, Meike
name: Boll, Lukas
Publisher: name: Universität Tübingen
Year: 2018
Subjects: subject: Suchtprävention , Schule , Medizin , Glücksspiel , Sozialpädagogik
subject: 360

description: Zweitveröffentlichung. Download von https://kfn.de/publikationen/kfn-forschungsberichte
Eremochares dives
Creators: name: Madl, Michael
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Sphecidae
Eremochares
Eremochares dives

description: Eremochares dives (BRULLÉ, 1833)
Ammophila dives BRULLÉ, 1833: KOHL 1885: 164 (tax.).
Ammophila dives BRULLÉ, 1833: DE DALLA TORRE 1897: 388 (world cat.).
* Ammophila nigritaria n.sp.: WALKER 1871a: 18 (descr. ♂ ♀, Tadjoura).
Ammophila nigritaria WALKER, 1871: KOHL 1885: 164 (syn.).
D i s t r i b u t i o n: Tadjoura
Eremochares dives is known from the Afrotropical (Djibouti), Oriental and Palaearctic (e.g. Bahrein, Saudi Arabia, Oman) regions. The record from Tadjoura is not mentioned in INNES BEY (1911: 111) and BOHART & MENKE (1976: 146).
description: Published as part of Madl, Michael, 2018, A preliminary catalogue of the Hymenoptera (Insecta) of the Republic of Djibouti, pp. 907-967 in Linzer biologische Beiträge 50 (2) on page 944, DOI: 10.5281/zenodo.3776452
MIMAC potential discovery and exclusion of neutralinos in the MSSM and NMSSM
Creators: name: Vasquez, Daniel Albornoz
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The MIMAC project aims to provide a nominal fluorine detector for directional detection of galactic dark matter recoil events. Its expected behavior reaches an important part of the predicted spin dependent elastic scattering interactions of the supersymmetric neutralino with protons. Hence, the parameter space in the MSSM and the NMSSM models with neutralino dark matter could be probed by such experimental efforts. In particular, a good sensitivity to spin dependent interactions tackles parameter space regions to which the predictions on spin independent interactions and indirect signatures are far below current and projected experiments.
description: Proceedings of the 3rd International conference on Directional Detection of Dark Matter (CYGNUS 2011), Aussois, France, 8-10 June 2011
ASCHEDULER: ADOPTION OF QUERY PRIORITY IN QUERY SCHEDULING FOR AVOIDING BAD QUERY MIX
Creators: name: M. ABDUL QADOOS BILAL
name: BAONING NIU
name: NAZIR AHMAD
Publisher: name: Zenodo
Year: 2023
Subjects: Multi-Tasking, Query Mix, Query Set, MPL3, Concurrent Queries, Database, Batch Queries, Parallel Processing, Response Time, Query Scheduler.

description: Abstract
Performance of databse management systems relates to low response time with maximum throughput. Therefore, it is necessary to adopt such scheme which can execute the workload with fewer time. Such scheme wich can also helpful in parallel query processing or can process batch queries simultenously, which can be used in developing the query mixes. Therefore, this research proposes a novel scheduler named as 'Ascheduler'. This proposed scheduler assigns the priority using modified MQI (Multiple Query Interaction) to each query on the basis of its resource usage for the completion of its execution which is coming for the developing the query mixes. The developed the query mixes by the proposed scheduler is categorized into best, good, moderate and bad quer mixes. This categorization of the query mixes is on the basis of resource utilization and their response time. It also keeps avoidance of developing bad query mixes by using previously developed query mixes response time and resource utilization by keeping record of priority of each query used in query mix as well as an individual query. The novel proposed scheduler named 'Ascheduler' also reduces the overall execution time of workload and perforem better in the other performace metrices like response time, categorization accuracy and interaction improvement score from the existing schedulers like Forst Come First Serve (FCFS) and Shortest Job First (SJF).
title: Chemo-induced hepatotoxicity: a survival guide.
Creators: name: LETURIA ETXEBERRIA, MARIA
Publisher: name: European Congress of Radiology
Year: 2020
Subjects: subject: Oncologic Imaging
subject: Abdomen
subject: Liver
subject: Oncology
subject: CT
subject: MR
subject: Ultrasound
subject: Complications
subject: Diagnostic procedure
subject: Biological effects
subject: Drugs / Reactions
subject: Neoplasia
subject: Not applicable

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To review the most widely used chemotherapeutic agents, as well as their mechanism of action and pattern of toxicity, focusing on radiological findings of chemo-induced hepatotoxicity...
Effects of cold wall quenching on unburned hydrocarbon emissions from a natural gas HPDI engine
Creators: name: Turcios, Marco Antonio
Publisher: name: University of British Columbia
Year: 2011

description: The quenching of hydrocarbon flames on cold surfaces is considered to be a potential source of unburned hydrocarbon (UHC) emissions from internal combustion engines, but its contribution to emissions has been difficult to determine due to the strong coupling between physics, chemistry and flame/wall geometry. This is particularly problematic for high pressure direct injection (HPDI) engines where high pressures, inhomogeneous mixtures and complex piston geometry are present. In this work, a computational model is implemented to determine the distance at which hydrocarbon flames quench on cold walls during numerical simulation. This model accounts for variable pressure, temperature, gas mixture and the geometry conditions. The model presented in this work is an extension of the experimental work done by Boust et. al. with stoichiometric premixed flames at low pressures. The validation of this model for high pressure and diffusion flames is presented and shows that the correct trends in heat flux and order of magnitude of quench distance are observed. This model is further refined for engine simulation and enhanced by a two-zone mass diffusion model to account for post-quench oxidation of boundary fuel. A selection of engine cases are simulated for a variety of different conditions to determine the spatial distribution and temporal evolution of unburned fuel cold surfaces. It was found that wall quenching on the piston contributes up to 50% of the total UHC during the combustion cycle, the majority of which is oxidized during the expansion stroke; the final contribution is at most 10% but frequently near or less than 1%. As the injection pressure was increased, quenching on the piston surface became more extensive, through the quenching thickness itself decreased. UHC from wall quenching occurs more readily for higher load conditions due to the richer mixtures and incomplete mixing. Altered engine timing introduced coupled effects of changed flame/wall interaction and combustion characteristics. The data obtained from the model can be used to evaluate attempts to reduce UHC by changing combustion chamber geometry.
Quenching of Meridional Circulation in Flux Transport Dynamo Models
Creators: name: Karak, Bidya Binay
name: Choudhuri, Arnab Rai
Publisher: name: arXiv
Year: 2011
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Guided by the recent observational result that the meridional circulation of the Sun becomes weaker at the time of the sunspot maximum, we have included a parametric quenching of the meridional circulation in solar dynamo models such that the meridional circulation becomes weaker when the magnetic field at the base of the convection zone is stronger. We find that a flux transport solar dynamo tends to become unstable on including this quenching of meridional circulation if the diffusivity in the convection zone is less than about 2 * 10^{11} cm^2/s. The quenching of alpha, however, has a stabilizing effect and it is possible to stabilize a dynamo with low diffusivity with sufficiently strong alpha-quenching. For dynamo models with high diffusivity, the quenching of meridional circulation does not produce a large effect and the dynamo remains stable. We present a solar-like solution from a dynamo model with diffusivity 2.8 * 10^{12} cm^2/s in which the quenching of meridional circulation makes the meridional circulation vary periodically with solar cycle as observed and does not have any other significant effect on the dynamo.
description: Consistent with the published version. Solar Physics, in press
Bioprocessing of human bone marrow mesecnchymal stem cells for the treatment of intervertebral disc degeneration
Creators: name: Yuan, Yifan
Publisher: name: University of Calgary
Year: 2012

description: Bibliography: p. 154-168
description: Some pages are in colour.
description: Lower back pain is a major medical problem in North America. From the biological point of view, the degeneration of intervertebral disc may be the main cause for lower back pain. The current study focused on using stem cell to differentiation into large number of healthy intervertebral disc cells. Human bone marrow mesenchymal stem cells (hBM­MSCs) were used. This project has been divided into two parts: I. hBM-MSCs expansion, 2. hBM-MSCs differentiation. Experiments were carried out manipulating culture medium components ( oxygen tension, calcium, serum, pH) and agitation to improve the expansion of hBM-MSCs in bioreactors. After 33 days of culture under the developed protocol, approximately I 03 fold increase over the inoculation density had been obtained in suspension bioreactor culture. The differentiation of MSCs to nucleus pulposus-like cells was performed by using multiple growth factor cocktails and notochordal conditioned medium. There was higher expression of genes and proteins specific for nucleus pulposus cells, after exposure of MSCs to conditioned medium over 21 days than in basal medium.
Declines in alcohol consumption in Australia: some challenges to the theory of collectivity
Creators: name: Mojica Perez, Yvette
name: Callinan, Sarah
name: Livingston, Michael
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 5203
subject: Clinical and health psychology
classificationCode: 4206
subject: Public health

description: No description supplied.
Statistical emulation of a tsunami model for sensitivity analysis and uncertainty quantification
Creators: name: Sarri, A.
name: Guillas, S.
name: Dias, F.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Applications (stat.AP)
subject: Atmospheric and Oceanic Physics (physics.ao-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: Due to the catastrophic consequences of tsunamis, early warnings need to be issued quickly in order to mitigate the hazard. Additionally, there is a need to represent the uncertainty in the predictions of tsunami characteristics corresponding to the uncertain trigger features (e.g. either position, shape and speed of a landslide, or sea floor deformation associated with an earthquake). Unfortunately, computer models are expensive to run. This leads to significant delays in predictions and makes the uncertainty quantification impractical. Statistical emulators run almost instantaneously and may represent well the outputs of the computer model. In this paper, we use the Outer Product Emulator to build a fast statistical surrogate of a landslide-generated tsunami computer model. This Bayesian framework enables us to build the emulator by combining prior knowledge of the computer model properties with a few carefully chosen model evaluations. The good performance of the emulator is validated using the Leave-One-Out method.
Monopolistic Competition and Optimum Product Diversity
Creators: name: Stiglitz, Joseph E.
name: Dixit, Avinash K.
Publisher: name: Columbia University
Year: 1977
Subjects: Economics

description: This article focuses on the impact of scale economies on whether a market solution will yield the socially optimum kinds and quantities of commodities in welfare economics. This article develops some models to study various aspects of the relationship between market and optimal resource allocation in the presence of some nonconvexities. The monopoly power, which is a necessary ingredient of markets with nonconvexities, is usually considered to distort resources away from the sector concerned. However, in the analysis monopoly power enables firms to pay fixed costs, and entry cannot be prevented, so the relationship between monopoly power and the direction of market distortion is no longer obvious. In the central case of constant elasticity utility function, the market solution was constrained Pareto optimal, regardless of the value of that elasticity. With variable elasticities, the bias could go either way, and the direction of the bias depended not on how the elasticity of demand changed, but on how the elasticity of utility changed. We suggested that there was some presumption that the market solution would be characterized by too few firms in the monopolistically competitive sector.
НЕКОТОРЫЕ АСПЕКТЫ УЧАСТИЯ АДВОКАТА В ПОДГОТОВКЕ ГРАЖДАНСКОГО ДЕЛА К СУДЕБНОМУ РАЗБИРАТЕЛЬСТВУ В РЕСПУБЛИКЕ УЗБЕКИСТАН
Creators: name: Муртазаев, Улугбек
Publisher: name: Zenodo
Year: 2023

description: в тезисе рассматривается значение адвокатской деятельности для решения судом задач при подготовке гражданских дел к судебному разбирательству. Наряду с этим отражена специфика оказания адвокатом содействия судье в решении каждой из этих задач с учетом действующего гражданского процессуального законодательства.
Enhanced bone repair using embryonic stem cells in a mouse model of impaired fracture healing
Creators: name: Taiani, Jaymi Tiffany
Publisher: name: University of Calgary
Year: 2012

description: Bibliography: p. 173-183
description: Some pages are in colour.
description: Includes copy of ethics approval and copyright permission. Original copies with original Partial Copyright Licence.
description: Fractures that occur in osteoporotic bone typically demonstrate impaired healing or non-union of the bony ends and current treatment methods for these types of injuries are inadequate. The field of tissue engineering offers promising treatment alternatives for diseases and injuries that affect tissues with a limited capacity for repair. Embryonic stem (ES) cells offer advantages over other stem cells types in that these cells are pluripotent, possessing the ability to generate any cell type in the body, and have a high capacity for self-renewal. This thesis describes the development of a novel product for the augmentation of bone fracture repair. Using protocols previously developed by our group, we initially attempted to differentiate bioreactor-expanded ES cells into osteoblasts and chondrocytes in stirred suspension culture systems. Surprisingly, we found that the bioreactor culture environment promoted ES cell pluripotency, resulting in limited cell differentiation. Through further experimentation, we found that exposure to a collagen I extracellular matrix induced osteoblastic differentiation of ES cells with greater efficacy than medium supplementation. Furthern1ore, the cell-loaded collagen constructs formed mineralized tissue nodules following subcutaneous implantation into immune-compromised mice. Subsequently, we developed a fracture model, using both nonnal and osteoporotic mice, to test the efficacy of the constructs to contribute to bone repair at an orthotopic site in vivo. Bone formation was enhanced in the mice treated with cell-loaded collagen constructs and the implanted cells were identified at the fracture site for up to 8 weeks. The formation of a small ectopic soft tissue mass in some of the recipient mice suggests that the collagen I matrix reduced but did not eliminate the tumorigenic potential of the cells. To our knowledge, the studies presented herein are the first of their kind to demonstrate the efficacy of a stem cell therapy for fracture repair in osteoporotic bone in vivo. The findings presented in this thesis highlight the importance of using an orthotopic implantation system to test in vivo functionality of ES cell-derived cells and provide an important foundation for future studies looking to develop stem cell therapies for bone injuries in larger animal models and people.
Moderate or deep local hypothermia does not prevent the onset of ischemia-induced dendritic damage
Creators: name: Tran, Sherri
Publisher: name: University of British Columbia
Year: 2011

description: Apical dendrites of layer 5 pyramidal neurons can rapidly undergo a structural perturbation within minutes of ischemia onset. This “blebbing” is a morphological phenomenon in which dendrites display regions of spherical and/or ellipsoid swellings, resembling a “beads-on-a-string” appearance. We investigated the acute (up to 2 hours after reperfusion) effects of localised cortical hypothermia, a well-recognised neuroprotective strategy, on ischemia-induced dendritic structural damage. Using in vivo two-photon imaging combined with a global ischemia model of occluding the common carotid arteries in C57Bl/6 mice, we monitored in real time these dynamic structural alterations during ischemia and reperfusion. We show that moderate (31°C) and deep hypothermia (22°C) delays but does not block the onset of dendritic blebbing during global ischemia. Deep hypothermic treatment also tended to promote more consistent recovery of dendritic structure during reperfusion. These results suggest that those employing therapeutic hypothermia will need to consider that it does not spare neurons from structural changes that are the result of ischemia, but may interact with mechanisms that control the onset of damage and recovery during reperfusion.
The Theory of R-parity, Unification and SUSY at the LHC
Creators: name: Perez, Pavel Fileviez
Publisher: name: arXiv
Year: 2012
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The simplest gauge theories for the conservation of R-parity in supersymmetry are discussed. We show how the minimal theory based on the B-L gauge symmetry predicts that R-parity must be spontaneously broken at the TeV scale. The most striking signals of these theories at the Large Hadron Collider are discussed. We present a realistic theory where the local baryon and lepton numbers are spontaneously broken at the supersymmetry breaking scale. The possibility to understand the conservation of R-parity in grand unified theories defined in four dimensions is mentioned.
A hybrid agent architecture for learning good cooperative behaviours for game characters
Creators: name: Paskaradevan, Sanjeev
Publisher: name: University of Calgary
Year: 2012

description: Bibliography: p. 92-95
description: Some pages are in colour.
description: Creating intelligent game agents is a difficult problem, cspcci??1lly in non-dctenninistic games where the outcome of an action cannot be determined with certainty. When we add in the complexity of team based games and the need for cooperation between the agents the problem can become even more complex. In this work, we provide a hybrid agent architecture that can be used to create and train agents to play team based games. Our architecture uses role based agent pools, communicated intentions, reinforcement learning, and evolutionary learning to train a team of agents. We test our architecture by applying it to the turn-based strategy game Battle for Wesnoth and demonstrate that we can train effective agents that can work together in teams to win against the built in \i\Tesnoth artificial intelligence.
Reproductive Cloning : A Re-expression of Maternal Genome
Creators: name: Garg, Rishabh
Publisher: name: Zenodo
Year: 2014
Subjects: Blue-print of life, DNA cloning, Genetic copy, Genome, Vegetative production

description: Cloning represents a novel reproduction alternative to produce an exact replica of the mother. However, it is deliberate production of genetically identical copy of an individual that does not allow new combinations to form and consequently triggers chances of uncontrolled gene expression in offspring. Each newly produced individual is a vegetative clone of the original. Clones contain identical sets of DNA, more precisely genes, in their nuclei.
Analysis of radarsat-2 polarimetric data for forest mapping
Creators: name: Maghsoudi, Yasser
Publisher: name: University of Calgary
Year: 2012

description: Bibliography: p. 123-140
description: Forests are a major natural resource of the Earth and control a wide range of environ­mental processes. Forests comprise a major part of the planet's plant biodiversity and have an important role in the global hydrological and biochemical cycles. Among the numerous potential applications of remote sensing in forestry, forest mapping plays a vital role for characterization of the forest in terms of species. Particularly, in Canada where forests occupy 45% of the territory, representing more than 400 million hectares of the total Canadian continental area. In this thesis, the potential of polarimetric SAR (PolSAR) Radarsat-2 data for forest mapping is investigated. This thesis has two principle objectives. First is to propose algorithms for ana­lyzing the PolSAR image data for forest mapping. There are a wide range of SAR parameters that can be derived fom PolSAR data. In order to make full use of the discriminative power offered by all these parameters, two categories of methods are proposed. The methods are based on the concept of feature selection and classifier en­semble. First, a nonparametric definition of the evaluation function is proposed and hence the methods NFS and CBFS. Second, a fast wrapper algorithm is proposed for the evaluation function in feature selection and hence the methods FWFS and FWCBFS. Finally, to incorporate the neighboring pixels information in classification an extension of the FWCBFS method i.e. CCBFS is proposed. The second objective of this thesis is to provide a comparison between leaf-on (summer) and leaf-off (fall) season images for forest mapping. Two Radarsat-2 images acquired in fine quad­ polarized mode were chosen for this study. The images were collected in leaf-on and leaf-of seasons. We also test the hypothesis whether combining the SAR parameters obtained fom both images can provide better results than either individual datasets may be useful for forest mapping. To assess the potential of the proposed methods their performance have been compared with each other and with the baseline classifiers. The baseline methods include the Wishart classifier, which is a commonly used classification method in PolSAR community, as well as an SVM classifier with the full set of parameters. f Experimental results showed a better performance of the leaf-of image compared to that of leaf-on image for forest mapping. It is also shown that combining leaf­ off parameters with leaf-on parameters can significantly improve the classification accuracy. Also, the classification results (in terms of the overall accuracy) compared to the baseline classifiers demonstrate the effectiveness of the proposed nonparametric scheme for forest mapping.