cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Hyperthermia-driven aberrations of secreted microRNAs in breast cancer in vitro
Creators: name: Erbes, Thalia
name: Hirschfeld, Marc
name: Waldeck, Silvia
name: Rücker, Gerta
name: Jäger, Markus
name: Willmann, Lucas
name: Kammerer, Bernd
name: Mayer, Sebastian
name: Gitsch, Gerald
name: Stickeler, Elmar
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Purpose: Expression profile alterations of nine breast cancer (BC)-associated secreted microRNAs (miRs) were determined under microenvironmental alterations occurring in tumour progression, metastasis or specific oncological treatment modalities. Thereto, the potential influence of the exogenic stimuli hypoxia, acidosis and hyperthermia was investigated in vitro. Material and methods: Four established BC cell lines were applied as in vitro BC model systems. Quantitative analyses of secreted microRNA specimens were performed by RNA isolation from cell culture supernatant and subsequent real-time PCR in cells under physiological versus hypoxic, acidic or hyperthermia conditions. Results: The in vitro application of exogenic stimuli hypoxia, extracellular acidosis and hyperthermia caused heterogeneous expression alterations for the investigated secreted miRNA phenotypes. The majority of relevant exogenic stimuli-dependent microRNA expression alterations were restricted to single events displaying distinct cell type and stimulus dependent correlations only. Most remarkably, hyperthermia triggered a uniform significant down-regulatory effect on the expression levels of the three secreted microRNAs miR-10b, miR-15b and miR-139, respectively. The marked decrease in miR-10b and miR-15b levels was detectable in all four, while miR-139 was found significantly reduced in three out of four BC cell lines. Conclusion: Hyperthermia-dependent down-regulatory influence on three distinct BC-related microRNAs in vitro generates translational aspects for clinical BC treatment, since the identified microRNAs miR-10b, miR-15b and miR-139 are known to have oncogenic as well as tumour suppressor functions in BC. However, an evaluation regarding the potential impact of microRNA-related hyperthermia-dependent alterations for innovative BC treatment approaches demands further analysis including in vivo data.
title: 02_0176
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Additional file 1 of NLG1, encoding a mitochondrial membrane protein, controls leaf and grain development in rice
Creators: name: Wen, Yi
name: Wu, Kaixiong
name: Chai, Bingze
name: Fang, Yunxia
name: Hu, Peng
name: Tan, Yiqing
name: Wang, Yueying
name: Wu, Hao
name: Wang, Junge
name: Zhu, Li
name: Zhang, Guangheng
name: Gao, Zhenyu
name: Ren, Deyong
name: Zeng, Dali
name: Shen, Lan
name: Dong, Guojun
name: Zhang, Qiang
name: Li, Qing
name: Qian, Qian
name: Hu, Jiang
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Supplementary Material 1
Strategies and Applications for Visible Light Mediated Photoredox Transformations in Organic Chemistry
Creators: name: Bourgeois, Sven
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2020
Subjects: Catalysis
Photoredox
Nickel
Cobalt
Gold
Nanoparticles

description: The field of photoredox catalysis has emerged as a prominent approach to synthetic chemistry over the past decade, offering powerful strategies in the activation of small molecules. Many of these systems have been proven to perform efficiently and with high selectivity under milder conditions compared to thermally driven reactions. These systems are instead powered by cheap and widely available light sources which excite catalysts capable of converting visible light into useful chemical energy. In general, this process is mediated by the engagement of organic substrates with the excited catalyst via single electron transfer events to produce reactive intermediates. However, despite these advantages there are currently only a limited number of photoredox catalysts available, almost all of which are based on iridium and ruthenium complexes. These precious earth-scarce metal catalysts are extremely expensive, toxic and difficult to manufacture, in addition to usually offering nothing with regards to recyclability. The field is also lacking a full understanding of the complete underlying mechanistic pathways responsible for these transformations. Herein, examples of a cheap and widely available nickel complex as an all-in-one photocatalyst and cross-coupling agent will be introduced in the direct C-H coupling of ethers to boronic acids. To the best of our knowledge, this is the first example of this type of multifunctionality for photochemistry and cross-coupling in a nickel catalyzed system. Additionally, the translation of the important Heck reaction into a heterogeneous, photochemically driven system will be demonstrated. The inorganic composite semiconductor Au@TiO2 can be used to harvest visible light to facilitate the coupling of olefins at an unprecedented combination of low temperature and lower cost, while providing exceptionally high turnover rates and recycling capabilities. Finally, this work will illustrate the use of aluminum oxide as a heterogeneous catalyst for the coupling of aryl chlorides to amines. Although not photochemically catalyzed, this particular work illustrates the ability of a cheap and abundant material to promote reactivity of ubiquitous aryl chlorides in a fully heterogeneous matter. Overall, the contents of this thesis report the development and implementation of lower cost and bench-stable catalytic systems capable of contending with their predecessors while simultaneously offering simple, facile separation of catalysts and reagents.
title: 01_0269
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
MUTAXASSIS TAYYORLASHDA KASBIY PSIXOLOGIYA FANINING O'RNI VA  AHAMIYATI
Creators: name: Umarov, Bekzod
name: Shamshidinova, Mushtariy
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqolada Kasbiy psixologiya fanining sohada qo’llash, natija ko’rsatish, yoshlar bilan muloqot qilish, to’g’ri kasb tanlashga yo’naltirish va malakasini oshirish  bo’yicha qilinishi lozim bo’lgan ishlar  bo’yicha ilmiy ma’lumotlar berilgan
Additional file 2 of Involvement of cell cycle and ion transferring in the salt stress responses of alfalfa varieties at different development stages
Creators: name: Yin, YanLing
name: Fan, ShuGao
name: Li, Shuang
name: Amombo, Erick
name: Fu, JinMin
Publisher: name: figshare
Year: 2023
Subjects: subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 2: Table S1. Primers used for qRT-PCR analysis.
OSL dating methodology: Evolution and architectural styles of a forced-regressive Holocene delta and megafan, Mitchell River, Gulf of Carpentaria, Australia
Creators: name: T. I. Lane
name: R. A. Nanson
name: B. K. Vakarelov
name: R. B. Ainsworth
name: S. E. Dashtgard
Publisher: name: Geological Society of London
Year: 2016
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: Mitchell River region optically stimulated luminescence (OSL) dating methodology and results
Secured System Architecture for the Internet of Things Using a Two Factor Authentication Protocol
Creators: name: Xiong, Chuan
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2020
Subjects: IoT
TFA
Fleet management
Security
MQTT
Infrastructure

description: The security concerns for the Internet of Things (IoT) systems have become a very important topic due to the rapid development of IoT in many different fields including industrial, commercial, personal, etc. Since the protocols used for IoT communication are usually very light-weighted, it is more insecure when compared with internet protocols due to the nature of IoT devices been resource limited. The development of IoT systems has been rapidly growing, however there is still no groundbreaking development for the security aspect of the IoT system. Hence, the existing security mechanisms are either not applicable in IoT systems or can no longer satisfy the security requirements for IoT systems. This thesis presents a solution that utilizes Two Factor Authentication (TFA) in the system’s authentication protocol, which requires both the Server and the Broker in the IoT systems to function as the authentication guards. The solution is designed to be generic so that it can be deployed into virtually any IoT system, and more importantly meets the security requirements and guidelines for IoT systems. Specifically for this thesis, the TFA solution will be deployed on a fleet management system for experimental and testing purposes. This is also a demonstration of how this TFA protocol can be used in different IoT applications. The experimental part of this thesis will include a prototype that includes the three main components the Server, the Broker and the Client, which will be coded using Python, then use Wireshark to act as an eavesdropper on the system. For the protocol verification part, the TFA protocol was modelled as a Coloured Petri Net and uses a Coloured Petri Net simulation tool to prove that the modelled Net indeed possess the properties of Coloured Petri Net.
Additional file 2 of NLG1, encoding a mitochondrial membrane protein, controls leaf and grain development in rice
Creators: name: Wen, Yi
name: Wu, Kaixiong
name: Chai, Bingze
name: Fang, Yunxia
name: Hu, Peng
name: Tan, Yiqing
name: Wang, Yueying
name: Wu, Hao
name: Wang, Junge
name: Zhu, Li
name: Zhang, Guangheng
name: Gao, Zhenyu
name: Ren, Deyong
name: Zeng, Dali
name: Shen, Lan
name: Dong, Guojun
name: Zhang, Qiang
name: Li, Qing
name: Qian, Qian
name: Hu, Jiang
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Supplementary Material 2
Menzies on causation: Difference-making and its flaws
Creators: name: Wilkinson, Hayden
Publisher: name: figshare
Year: 2016
Subjects: subject: Philosophy
subject: FOS: Philosophy, ethics and religion

description: Early counterfactual theories of causation such as that of Lewis (1973) tend to be beset by various counterintuitive consequences such as the proliferation of profligate causes, and an insensitivity to context. As I describe in this paper, Menzies (2004) builds on Lewis’ account and formulates a novel interpretation of causation as differencemaking; that is, what is meant by claiming that some event or factor makes a difference to another. Menzies’ approach attempts to limit profligate causes and allow for context-sensitivity. However, as I will argue, he is not entirely successful as his theory still faces problems of profligacy of causes specifically in absence causation. Moreover, its context dependency has antirealist implications and provides an untoward interpretation of cases of socalled ‘redundant causation’.
Proceedings in Marine Biology - Volume 4, Number 1, 2024
Creators: name: Stach, Thomas
name: Lüter, Carsten
Publisher: name: Humboldt-Universität zu Berlin
Year: 2024
Subjects: subject: 570 Biologie

description: “Proceedings in Marine Biology” is an international journal publishing original research by graduate students on all aspects of marine biology. Subjects covered include: ecological surveys and population studies of oceanic, coastal and shore communities; physiology and experimental biology; taxonomy, morphology and life history of marine animals and plants. Papers are also published on techniques employed at sea for sampling, recording, capture and observation of marine organisms. This volume deals exlusively with the results of the research field trip of the Humboldt-Universität zu Berlin to the AWI - Biologische Anstalt Helgoland (Germany) from 26.09. - 05.10.2023
Čapek’s costly route to relativistic presentism
Creators: name: Wilkinson, Hayden
Publisher: name: figshare
Year: 2016
Subjects: subject: Philosophy
subject: FOS: Philosophy, ethics and religion

description: There appears to be a clear conflict between presentism and the special theory of relativity, as pointed out by Putnam and Gödel. Čapek contests this by proposing a novel form of 'here-now' presentism under which the existent present is restricted to a single spacetime point. Such a present overcomes many of the criticisms which have plagued previous presentist views and, particularly, provides a definition of the present which is frame-invariant. By doing so, it succeeds in avoiding any direct contradiction with special relativity. In this paper, however, I critique Čapek's formulation of presentism on the grounds of: its implications for the existence of sized objects; and the difficulties it produces for both distant and past events. The view he describes places considerable restrictions on one’s worldview and hence, I argue, is not a viable metaphysical position.
Additional file 3 of NLG1, encoding a mitochondrial membrane protein, controls leaf and grain development in rice
Creators: name: Wen, Yi
name: Wu, Kaixiong
name: Chai, Bingze
name: Fang, Yunxia
name: Hu, Peng
name: Tan, Yiqing
name: Wang, Yueying
name: Wu, Hao
name: Wang, Junge
name: Zhu, Li
name: Zhang, Guangheng
name: Gao, Zhenyu
name: Ren, Deyong
name: Zeng, Dali
name: Shen, Lan
name: Dong, Guojun
name: Zhang, Qiang
name: Li, Qing
name: Qian, Qian
name: Hu, Jiang
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Supplementary Material 3
Reference target extraction for point cloud intensity normalization in Scan to BIM
Creators: name: Rashdi, Rabia
Publisher: name: Zenodo
Year: 2022

description: Transport infrastructure and Building Information Modelling (BIM) play a valuable role in creating smart cities, to make the environment more efficient, safe and secure. Mobile laser scanning (MLS) has become an important tool for surveying the environment It provides rich 3D point clouds with geometric and radiometric details which is useful in detecting road inventories. Despite its increasing demand for detailed 3D representation, some drawbacks are associated with MLS data First, MLS point clouds produce billions of points, resulting in a massive volume of data. Furthermore, MLS point clouds have a high spatial resolution, capturing unwanted objects and noise in the scene such as moving objects MLS cannot capture complete coverage of the scene beyond the roadways because of the occlusions affected by buildings and trees Data acquired from multiple laser scanners at different timings, with varying point densities make point cloud processing challenging . Hence, the need to normalize point cloud intensity is necessary to have a uniform value, which can be utilized in various scenarios.This paper proposes an approach for intensity calibration and extraction of target surfaces for the application of Scan to BIM framework, which can be further used for intensity normalization of the point clouds in transport infrastructure
Charity evaluation: Action on Smoking and Health
Creators: name: Wilkinson, Hayden
Publisher: name: figshare
Year: 2016
Subjects: Uncategorized

description: We are quite confident that, of the charities operating in the UK, ASH is not only one of the most costeffectivein reducing the incidence of Alzheimer’s disease, but also improve health more generally.Although it works through indirect means, through tobacco control and also through lobbying, andalthough its costeffectivenessdoes not exceed that of our top recommended charities, we do believethat the expected impact of ASH’s activities on Alzheimer’s morbidity and mortality in particular andother diseases more generally, are quite considerable. This is due to the consistently high quality ofits implementation, how wellplacedit is to effectively lobby and advocate for tobacco control, its pastsuccesses (which were both sizeable and also achieved on quite a low budget), its strategicapproach to future activities, and the projected costeffectivenessof those future activities.
Additional file 4 of NLG1, encoding a mitochondrial membrane protein, controls leaf and grain development in rice
Creators: name: Wen, Yi
name: Wu, Kaixiong
name: Chai, Bingze
name: Fang, Yunxia
name: Hu, Peng
name: Tan, Yiqing
name: Wang, Yueying
name: Wu, Hao
name: Wang, Junge
name: Zhu, Li
name: Zhang, Guangheng
name: Gao, Zhenyu
name: Ren, Deyong
name: Zeng, Dali
name: Shen, Lan
name: Dong, Guojun
name: Zhang, Qiang
name: Li, Qing
name: Qian, Qian
name: Hu, Jiang
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Supplementary Material 4
Cause report: Climate change
Creators: name: Wilkinson, Hayden
Publisher: name: figshare
Year: 2016
Subjects: Uncategorized

description: Climate change poses a considerable threat to human health and well being, and is directlyattributable to human activities.The scope of the problem is potentially greater than many of the individual diseases and risk factorswhich currently influence morbidity and mortality, and warrants a timely and substantial response onthe part of governments and institutions which may be able to enact substantial mitigation policies.However, in terms of investment, the problem of climate change appears to be far from neglected(see below) and, due to a lack of cost-effective interventions which prevent or mitigate climaticchange, it is not an area which is particularly tractable.
MOESM1 of ELISA is superior to bacterial culture and agglutination test in the diagnosis of brucellosis in an endemic area in China
Creators: name: Xu, Nannan
name: Wang, Wei
name: Chen, Fengzhe
name: Li, Wen
name: Wang, Gang
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Table S1. Clinical follow up of patients with a diagnosis of Brucellosis
Supplementary Material for: Difference in Transcranial Doppler Velocity and Patient Age between Proximal and Distal Middle Cerebral Artery Vasospasms after Aneurysmal Subarachnoid Hemorrhage
Creators: name: Kohama, M.
name: Sugiyama, S.
name: Sato, K.
name: Endo, H.
name: Niizuma, K.
name: Endo, T.
name: Ohta, M.
name: Matsumoto, Y.
name: Fujimura, M.
name: Tominaga, T.
Publisher: name: Karger Publishers
Year: 2016
Subjects: Medicine

description: Background: Transcranial Doppler (TCD) is used to monitor cerebral vasospasm after subarachnoid hemorrhage (SAH), but its diagnostic ability is reported to be limited. Therefore, the purpose of this study was to investigate the relationship between the diagnosability of TCD and the localization of the vasospasm. Methods: This retrospective study included 20 patients who presented with symptomatic vasospasm after SAH. All 20 patients underwent daily TCD examinations and cerebral angiography after the onset of delayed cerebral ischemia. We defined positive findings on TCD as a maximum flow velocity >200 cm/s or as a mean flow velocity >120 cm/s at the horizontal part of the middle cerebral artery (MCA). We also examined the site of vasospasm on cerebral angiography. Results: Fourteen patients had true-positive findings on TCD examination, and cerebral angiography showed diffuse vasospasm involving the horizontal segment of the MCA. However, 6 patients had false-negative findings on TCD examination, and cerebral angiography showed vasospasm localized at the distal part of the MCA (the insular and/or cortical segments). The patients with proximal vasospasm were significantly younger than those with distal vasospasm. Blood flow velocity at initial TCD and the increase in velocity at the onset of vasospasm were lower and smaller, respectively, in the distal vasospasm group. Conclusions: In patients with cerebral vasospasm localized at the distal part of the MCA, flow velocity at the horizontal segment of the MCA did not increase to the level we defined as positive. To avoid such false negatives, a slight increase in velocity on TCD should be considered as positive in distal vasospasm cases, especially in older patients.
Unraveling influencing hydrogeological factors contributing to land subsidence in the Tianjin Plain of China by a multi-scale geographically weighted regression model and monitoring data
Creators: name: Longa, Zhao
name: Yumeic, Li
name: Yongb, Luo
Publisher: name: Geological Society of London
Year: 2024
Subjects: classificationCode: 3705
subject: Geology
subject: FOS: Earth and related environmental sciences

description: Simulation results for OLS, GWR, and MGWR models used in this study.
Safety, tolerability, pharmacokinetics, and pharmacodynamics of SHR-2010, a novel anti-MASP-2 antibody, in healthy volunteers: a randomized, double-blind, placebo-controlled phase 1 study
Creators: name: Lin, Pingping
name: Wang, Chenjing
name: Hu, Xiaotong
name: Fang, Lin
name: Lin, Hongda
name: Sun, Feifei
name: Huang, Rong
name: Ban, Rongxin
name: Feng, Sheng
name: Gao, Zhenyan
name: Shen, Kai
name: Cao, Yu
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Marine Biology
subject: Cancer
subject: Mental Health

description: This first-in-human study assessed the safety, tolerability, pharmacokinetics, and pharmacodynamics of SHR-2010, a novel humanized IgG4 monoclonal antibody targeting mannan-binding lectin serine protease-2, in healthy adults. In this randomized, double-blind, phase 1 study, eligible participants were randomly assigned to single ascending doses of SHR-2010 or placebo (32 via intravenous drip: 6:2; 0.3, 1.5, 4.0, and 8.0 mg/kg; 29 via subcutaneous injection: 8:2; 4.0, 8.0, and 12.0 mg/kg). The primary endpoints were safety and tolerability. SHR-2010 was well tolerated. Treatment-related adverse events (TRAEs) were similar in SHR-2010 groups (55.3% [26/47]) and placebo groups (78.6% [11/14]). No deaths or severe TRAEs were reported. In the intravenous dose groups, the Cmax increased proportionally with the dose, while the AUC increased slightly more than the dose increment. In the subcutaneous injection groups, Cmax and AUC demonstrated a linear relationship with dose. SHR-2010 demonstrated a notable inhibitory effect on lectin pathway, with the mean maximum inhibition rates exceeding 80.0% across the tested doses, compared to 6.7% with placebo. SHR-2010 was safe and well tolerated after a single dose and exhibited robust blockade of the lectin pathway, supporting further development. The trial is registered at ClinicalTrials.gov (NCT05398510).
title: 01_0273
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Robert Naviaux
Creators: name: Leibowitch, Jacques (1942-2020)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: 1 fichier (2 pages)
description: Autres destinataires : Yanina Wachtfogel et Michael Stevens (Bristol-Myers Squibb).
Effects of exotic pasture grasses on biodiversity in the Mary River catchment, Northern Territory
Creators: name: Beggs, Kerry
Publisher: name: Charles Darwin University
Year: 2010

description: The Mary River catchment, Northern Territory, is a multiple-use region which has significance not only as highly productive pastoral land but also for conservation values. Concerns have been raised in recent years regarding the spread of exotic pasture grasses, particularly gamba grass (Andropogon gayanus) and para grass (Urochloa mutica), from pastoral properties into natural habitats and their possible threat to biological diversity. The comprehensive field surveys of terrestrial vertebrate fauna in the floodplain and savanna woodland habitats within the catchment provide the first quantitative evidence on the ecological effects of para grass and gamba grass. The findings of my research indicate that the conversion of native vegetation to communities dominated by dense para grass or gamba grass, could lead to a substantial loss of plant and animal biodiversity, as well as reductions in the size of some animal populations currently present in the catchment. In the floodplain habitat, 87% of native plant and 66% of native animal species were not recorded in areas where para grass cover was greater than 40%. In the savanna woodland habitat, a similar although less pronounced result was observed, with 47% of native plant, 18% of native vertebrate species not recorded in either woodland areas with a dense gamba grass understorey (i.e. >70% of the total ground-level plant cover) or paddocks of gamba grass. Many individual species (mostly small reptiles and birds) were shown to decline in abundance as the cover of para grass or gamba grass increased. Management responses at a range of levels, in conjunction with monitoring to assess the efficacy of any action, are required if conservation goals for the catchment are to be realised. The eradication of para grass and gamba grass on conservation reserves within the Mary River catchment should become a high priority. Efforts to contain these exotic pasture grasses on unreserved land, particularly pastoral properties bordering conservation reserves, need to be intensified. A monitoring program that involves a combination of direct monitoring of the exotic grasses (e.g. aerial surveys), and on-ground flora and fauna surveys (possibly streamlined to target indicator groups only) is recommended.
title: Urban and rural perceptions toward the reintrocution of wood bison in Alaska, USA
Creators: name: Silveira, Flavia Franchini
Publisher: name: Memorial University of Newfoundland
publisherIdentifier: https://ror.org/04haebc03
publisherIdentifierScheme: ROR
Year: 2024

description: This study investigates public perceptions surrounding wood bison restoration in Alaska, differentiating responses by urban and rural settings and hunting participation. It establishes and compares baseline levels of social acceptability norms, trust in the wildlife agency, and perceived impacts (both risks and benefits) of the reintroduction. The study encompasses two major urban centers and four rural villages near the release site. Data collected through mail surveys and structured interviews are analyzed using t-tests and ANOVA, with reported effect sizes. Overall, the public holds positive views regarding bison and its management. Notably, rural participants display higher levels of trust, management support, and expectations of impacts. Conversely, urban hunters exhibit the lowest endorsement of proposed management actions. These findings underline the importance of tailored communication and education efforts to address variations in perceptions among distinct groups and ensure effective conservation strategies. The study also highlights potential opportunities and recommendations tied to the wood bison reintroduction initiative.
Additional file 5 of NLG1, encoding a mitochondrial membrane protein, controls leaf and grain development in rice
Creators: name: Wen, Yi
name: Wu, Kaixiong
name: Chai, Bingze
name: Fang, Yunxia
name: Hu, Peng
name: Tan, Yiqing
name: Wang, Yueying
name: Wu, Hao
name: Wang, Junge
name: Zhu, Li
name: Zhang, Guangheng
name: Gao, Zhenyu
name: Ren, Deyong
name: Zeng, Dali
name: Shen, Lan
name: Dong, Guojun
name: Zhang, Qiang
name: Li, Qing
name: Qian, Qian
name: Hu, Jiang
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Supplementary Material 5
A cross-cultural examination of the impact of social organisational and individual factors on educational technology acceptance between British and Lebanese university students
Creators: name: Tarhini, Ali
name: Hone, Kate
name: Xiaohui Liu
Publisher: name: figshare
Year: 2016
Subjects: subject: 130103 Higher Education
subject: FOS: Educational sciences
subject: Education
subject: 140301 Cross-Sectional Analysis
subject: FOS: Economics and business

description: This paper examines the social, organisational and individual factors that may affect students’ acceptance of e-learning systems in higher education in a cross-cultural context. A questionnaire was developed based on an extended technology acceptance model (TAM). A total sample of 1173 university students from two private universities in Lebanon and one university in England participated in this study. After performing the satisfactory reliability and validity checks, the hypothesised model was estimated using structural equation modeling. The findings of this study revealed that perceived usefulness (PU), perceived ease of use (PEOU), social norms (SNs), perceived quality of work life (QWL), computer self-efficacy (SE) and facilitating conditions (FC) are significant determinants of behavioural intentions (BIs) and usage of e-learning system for the Lebanese and British students. QWL, the newly added variable, was found the most important construct in explaining the causal process in the model for both samples. Differences were found between Lebanese and British students with regard to PEOU, SN, QWL, FC, SE and actual usage; however, no differences were detected in terms of PU and BI. Overall, the proposed model achieves acceptable fit and explains for 69% of the British sample and 57%of the Lebanese sample of its variance which is higher than that of the original TAM. Our findings suggest that individual, social and organisational factors are important to consider in explaining students’ BI and usage of e-learning environments.
SOYA O'SIMLIGINING QISHLOQ XO'JALIGIDAGI AHAMIYATI
Creators: name: Umarov, Bekzod
name: Shamshidinova, Mushtariy
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqolada soya o’simligining xususiyatlari, morfologiyasi, anatomiyasi, biologik tasnifi, yetishtirilishi, qishloq xo’jaligidagi ahamiyati va unumdorligini oshirish uchun qilinishi lozim bo’lgan ishlar bo’yicha ilmiy ma’lumotlar keltirilgan.
Emergency Rooms in Turkey
Creators: name: Durmus, Ensar
Publisher: name: Zenodo
Year: 2021
Subjects: Emergency room
Turkey

description: Emergency services in Turkey are divided into three levels according to the size of the service they provide, the facilities they have, and their physical size: First-level emergency services: These are the units where general practitioners provide healthcare services. In cases when specialist experience is demanded, the relevant branch specialist can be reached by phone. In these emergency services, specialist physicians do not keep on-boarding shifts, and they arrive hospital from home if required. When challenged with complex or very urgent cases, they are usually referred to higher centers. These emergency services are found in hospitals with less than 100 beds. Furthermore, they can be up to 400 square meters in size. Second-level emergency services: In these units, emergency healthcare services are presented by general practitioners, and one specialist physician from each of the internal and surgical branches is onboarding duty at the hospital. These services are commonly located in hospitals with 100-300 beds and are 400-800 square meters in size. Computed tomography and ultrasound utilities are available in these emergency services. Third-level emergency services: These units are high-level emergency services that can admit all kinds of emergency cases. They are established in hospitals with more than 300 beds; moreover, they have a minimum area of 800 square meters. In these emergency services, general practitioners and emergency medicine specialists work collectively, and a specialist physician from each branch is onboarding shifts to respond to emergency services demands. These emergency services have personnel support and medical devices that can observe patients in the requirement of intensive care.
Additional file 6 of NLG1, encoding a mitochondrial membrane protein, controls leaf and grain development in rice
Creators: name: Wen, Yi
name: Wu, Kaixiong
name: Chai, Bingze
name: Fang, Yunxia
name: Hu, Peng
name: Tan, Yiqing
name: Wang, Yueying
name: Wu, Hao
name: Wang, Junge
name: Zhu, Li
name: Zhang, Guangheng
name: Gao, Zhenyu
name: Ren, Deyong
name: Zeng, Dali
name: Shen, Lan
name: Dong, Guojun
name: Zhang, Qiang
name: Li, Qing
name: Qian, Qian
name: Hu, Jiang
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Supplementary Material 6
Solvation structure of sodium chloride (Na+–Cl-) ion pair in acetonitrile (AN)–dimethyl formamide (DMF) mixtures
Creators: name: Ujwala N. Patil
name: Bhalachandra L. Tembe
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Marine Biology
subject: Inorganic Chemistry
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: Computational Biology

description: Solvation structures of Na+–Cl− ion pair are investigated in acetonitrile (AN)–dimethylformamide (DMF) isodielectric mixtures. The potentials of mean force of Na+–Cl− in the five compositions of mixtures show minima corresponding to a contact ion pair (CIP) and a solvent-shared ion pair (SShIP). The solvent-separated ion pair minima are present in lower mole fractions of AN (xAN ≤ 0.50). CIPs are found to be more stable than the SShIPs. From a thermodynamic decomposition of the potentials of mean force, we find that the formation of the ion pair is entropically driven in these compositions. The most stable CIP is in pure AN. The local solvation structures around the ion pair are analysed through the running coordination numbers, excess coordination numbers, solvent orientational distributions and density profiles. We find that both Na+ and Cl− are preferentially solvated by DMF.
Managing the costs of CO2 abatement in the cement industry
Creators: name: Rootzén, Johan
name: Johnsson, Filip
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: This article investigates how the costs associated with deep reductions in CO2 emissions from the cement industry will influence the costs across the entire value chain from cement production to the eventual end-use, in this case a residential building. The work is motivated by the substantial difference between the pricing of CO2 emissions and the costs of mitigation at the production sites of energy-intensive industries, such as cement manufacture. By examining how CO2 trading and investments in low-carbon kiln systems affect costs and prices further up the supply chain of cement our analysis provides new perspectives on the costs of industry abatement of CO2 and on the question of who could or should pay the price of such abatement. The analysis reveals that the cost impacts decrease substantially at each transformation stage, from limestone to final end-uses. The increase in total production costs for the residential building used as the case study in this work is limited to 1%, even in the cases where the cement price is assumed to be almost doubled. Policy relevance With the price of emission allowances under the EU Emissions Trading System (EU ETS) currently far below the levels required to unlock investments in low-CO2 production processes in carbon-intensive industry (i.e. petroleum refining, iron and steel production and cement manufacturing), this article seeks to pave the way for a discussion on complementary policy options. The results from this study, using the supply of cement and concrete to a residential building as a case study, suggest that because cement and concrete typically account for a limited proportion of the total cost of most construction and civil engineering projects, a policy scheme designed to allocate more of the costs of CO2 abatement to the end-users (of cement) would neither (significantly) alter the cost structure nor (dramatically) increase overall project costs.
Separate and combined effects of genetic variants and pre-treatment whole blood gene expression on response to exposure-based cognitive behavioural therapy for anxiety disorders
Creators: name: Coleman, Jonathan R.I.
name: Lester, Kathryn J.
name: Roberts, Susanna
name: Keers, Robert
name: Lee, Sang Hyuck
name: Jong, Simone De
name: Gaspar, Héléna
name: Teismann, Tobias
name: Wannemüller, André
name: Schneider, Silvia
name: Jöhren, Peter
name: Margraf, Jürgen
name: Gerome Breen
name: Eley, Thalia C.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Plant Biology
subject: 60506 Virology

description: Objectives: Exposure-based cognitive behavioural therapy (eCBT) is an effective treatment for anxiety disorders. Response varies between individuals. Gene expression integrates genetic and environmental influences. We analysed the effect of gene expression and genetic markers separately and together on treatment response. Methods: Adult participants (n ≤ 181) diagnosed with panic disorder or a specific phobia underwent eCBT as part of standard care. Percentage decrease in the Clinical Global Impression severity rating was assessed across treatment, and between baseline and a 6-month follow-up. Associations with treatment response were assessed using expression data from 3,233 probes, and expression profiles clustered in a data- and literature-driven manner. A total of 3,343,497 genetic variants were used to predict treatment response alone and combined in polygenic risk scores. Genotype and expression data were combined in expression quantitative trait loci (eQTL) analyses. Results:Expression levels were not associated with either treatment phenotype in any analysis. A total of 1,492 eQTLs were identified with q Conclusions: We assessed gene expression alone and alongside genetic variants. No associations with treatment outcome were identified. Future studies require larger sample sizes to discover associations.
Additional file 7 of NLG1, encoding a mitochondrial membrane protein, controls leaf and grain development in rice
Creators: name: Wen, Yi
name: Wu, Kaixiong
name: Chai, Bingze
name: Fang, Yunxia
name: Hu, Peng
name: Tan, Yiqing
name: Wang, Yueying
name: Wu, Hao
name: Wang, Junge
name: Zhu, Li
name: Zhang, Guangheng
name: Gao, Zhenyu
name: Ren, Deyong
name: Zeng, Dali
name: Shen, Lan
name: Dong, Guojun
name: Zhang, Qiang
name: Li, Qing
name: Qian, Qian
name: Hu, Jiang
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Supplementary Material 7
Additional file 8 of NLG1, encoding a mitochondrial membrane protein, controls leaf and grain development in rice
Creators: name: Wen, Yi
name: Wu, Kaixiong
name: Chai, Bingze
name: Fang, Yunxia
name: Hu, Peng
name: Tan, Yiqing
name: Wang, Yueying
name: Wu, Hao
name: Wang, Junge
name: Zhu, Li
name: Zhang, Guangheng
name: Gao, Zhenyu
name: Ren, Deyong
name: Zeng, Dali
name: Shen, Lan
name: Dong, Guojun
name: Zhang, Qiang
name: Li, Qing
name: Qian, Qian
name: Hu, Jiang
Publisher: name: figshare
Year: 2023
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Computational Biology

description: Supplementary Material 8