cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin
Creators: name: Singh, Karmveer
name: Camera, Emanuela
name: Krug, Linda
name: Basu, Abhijit
name: Kumar, Pandey Rajeev
name: Munir, Saira
name: Wlaschek, Meinhard
name: Kochanek, Stefan
name: Schorpp-Kistner, Marina
name: Picardo, Mauro
name: Angel, Peter
name: Niemann, Catherin
name: Maity, Pallab
name: Scharffetter-Kochanek, Karin
Publisher: name: Universität Ulm
Year: 2018
Subjects: subject: Skin stem cells
subject: DDC 610 / Medicine & health
subject: Skin diseases
subject: Cell differentiation
subject: Stem cells
subject: Transcription factors
subject: Hautkrankheit
subject: Zelldifferenzierung
subject: Transkriptionsfaktor

description: Transcription factors ensure skin homeostasis via tight regulation of distinct resident stem cells. Here we report that JunB, a member of the AP-1 transcription factor family, regulates epidermal stem cells and sebaceous glands through balancing proliferation and differentiation of progenitors and by suppressing lineage infidelity. JunB deficiency in basal progenitors results in a dermatitis-like syndrome resembling seborrheic dermatitis harboring structurally and functionally impaired sebaceous glands with a globally altered lipid profile. A fate switch occurs in a subset of JunB deficient epidermal progenitors during wound healing resulting in de novo formation of sebaceous glands. Dysregulated Notch signaling is identified to be causal for this phenotype. In fact, pharmacological inhibition of Notch signaling can efficiently restore the lineage drift, impaired epidermal differentiation and disrupted barrier function in JunB conditional knockout mice. These findings define an unprecedented role for JunB in epidermal-pilosebaceous stem cell homeostasis and its pathology.
Meilleures pratiques en maîtrise des déchets des communes
Creators: name: Bilitewski, Bernd
name: Wagner, Jörg
name: Reichenbach, Jan
Publisher: name: My University
Year: 2018
Subjects: subject: Abfallwirtschaft
subject: Deponierung
subject: maîtrise des déchets des communes
subject: Abfall | Ressourcen
subject: Waste | Resources

description: The need to curb natural resources depletion and climate change and secure a healthy living space for an ever growing human society has become a global challenge which increases the demand to minimise waste generation and manage arising wastes effectively and sustainably on a worldwide scale. This task applies to all countries independently from their status of development. Many countries are therefore faced with the necessity to initiate a process of transformation from the conventional scheme of waste disposal through simple dumping or landfilling towards the gradual implementation of a closed loop management of their wastes.
Supplementary document for 3D Reconstruction of weakly scattering objects from 2D intensity-only measurements using the Wolf transform - 5005246.pdf
Creators: name: Emam, Ahmed Bassam
name: Lim, Joowon
name: Antoine, Elizabeth
name: Psaltis, Demetri
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Classical and Physical Optics

description: Supplement 1
Lubricin as a tool for controlling adhesion in vivo and ex vivo
Creators: name: Manasa, Clayton S.
name: Moraes Silva, Saimon
name: Desroches, Pauline E.
name: Dennaoui, Jessair
name: Russo, Mathew J.
name: Han, Mingyu
name: Quigley, Anita F.
name: Greene, George W.
name: Kapsa, Robert M. I.
name: Moulton, Simon
Publisher: name: Swinburne
Year: 2024

description: The ability to prevent or minimize the accumulation of unwanted biological materials on implantable medical devices is important in maintaining the long-term function of implants. To address this issue, there has been a focus on materials, both biological and synthetic, that have the potential to prevent device fouling. In this review, we introduce a glycoprotein called lubricin and report on its emergence as an effective antifouling coating material. We outline the versatility of lubricin coatings on different surfaces, describe the physical properties of its monolayer structures, and highlight its antifouling properties in improving implant compatibility as well as its use in treatment of ocular diseases and arthritis. This review further describes synthetic polymers mimicking the lubricin structure and function. We also discuss the potential future use of lubricin and its synthetic mimetics as antiadhesive biomaterials for therapeutic applications.
Barriers of innovation of food processing SMIs in Malaysia: an empirical study
Creators: name: Mohd Jani, Mohd Fauzi
name: Alam, Syed Shah
Publisher: name: Swinburne
Year: 2024

description: The purpose of this study is to examine the important barriers that affecting innovation process of food processed based SMIs in Malaysia. From the analysis it was found that there are various factors that could prevent the food processed based SMIs to innovate. The result of this study shows that some barriers did have some significant impact on the firm innovation process among food processing SMIs in Malaysia. The findings this research will be useful for everybody particularly for the SME Corporation and Ministry of Entrepreneurship Development of Malaysia to get some ideas and develop suitable training programs to help and assist the SMIs owner in the future endeavor. The paper finalizes with some conclusions for policy makers, industry and other actors, and also future research.
Self-criticism and personality functioning predict patterns of symptom change in major depressive disorder
Creators: name: Zeeck, Almut
name: Von Wietersheim, Jörn
name: Weiss, Heinz
name: Hermann, Sabine
name: Endorf, Katharina
name: Lau, Inga
name: Hartmann, Armin
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: depression
subject: outcome
subject: prediction
subject: self-criticism
subject: hospital treatment
subject: personality functioning
subject: DDC 610 / Medicine & health
subject: Depressive disorder, Major
subject: Self concept
subject: Self-assessment
subject: Depression
subject: Stationäre Behandlung
subject: Selbstbild

description: Aim of the study was to identify patient variables that predict specific patterns of symptom course during and after hospital treatment for major depressive disorder (MDD). In a sample of 518 patients, four pairs of clinically relevant patterns of symptom change were contrasted. The time points of measurement were admission, discharge, 3 and 12 month after discharge. CATREG was used to identify the best sets of predictors from 28 variables. A greater reduction in self-criticism during hospital treatment was the strongest predictor of rapid and sustained improvement. Traumatic childhood experiences and lower abilities for communication with others predicted a transient relapse after discharge, while a co-morbid personality disorder and higher level of anxiety differentiated between those with a persistent relapse and those with only a transient relapse in depressive symptoms following discharge. Overall, patients with less severe depression at admission, better abilities in self-perception, and less self-criticism (baseline and/or greater reduction during treatment) showed a better outcome after 1 year. There is limited generalizability to other countries and treatment settings. Data on personality functioning were not available for all patients and findings are correlational in nature. However, findings are in support of a psychotherapeutic focus on a reduction of self-criticism in MDD. Patient with traumatization, a co-morbid personality disorder and lower abilities to communicate their emotional needs should get specific attention and support after discharge from hospital treatment.
Linking individual differences in satisfaction with each of Maslow's needs to the Big Five personality traits and Panksepp's primary emotional systems
Creators: name: Montag, Christian
name: Sindermann, Cornelia
name: Lester, David
name: Davis, Kenneth Leon
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Maslow's hierarchy of needs
subject: Big five of personality
subject: Primary emotional systems
subject: Affective neuroscience theory
subject: Affective neuroscience personality scales
subject: Clinical psychology
subject: Individual differences
subject: Well-being
subject: DDC 150 / Psychology
subject: Motivation (Psychology)
subject: Need (Psychology)
subject: Psychology, Clinical
subject: Neuroscience
subject: Personality
subject: Neuropsychologie
subject: Kognitionswissenschaft
subject: Persönlichkeitspsychologie

description: Maslow's hierarchy of needs is one of the most impactful theories in motivation psychology and personality science. Therefore, it is surprising that studies linking individual differences in a person's current satisfaction with each of Maslow's needs to the Big Five personality traits are rare. In the present study of 850 participants, associations between the Need Satisfaction Inventory and the Big Five personality traits were examined for the first time. In addition, the administration of the Affective Neuroscience Personality Scales provided an evolutionary framework for the present research. Individual differences in the Need Satisfaction Inventory were assessed, but participants were also asked about the current importance of each of Maslow's needs in their lives. This latter approach to viewing Maslow's needs (general rated importance of each need in the life of a person) showed strong deviations from Maslow's proposed order in the classic pyramid depicting the hierarchy of needs.
De novo mutations in SOD1 are a cause of ALS
Creators: name: Müller, Kathrin
name: Oh, Ki-Wook
name: Nordin, Angelica
name: Panthi, Sudhan
name: Kim, Seung Hyun
name: Nordin, Frida
name: Freischmidt, Axel
name: Ludolph, Albert C
name: Ki, Chang Seok
name: Forsberg, Karin
name: Weishaupt, Jochen
name: Kim, Young-Eun
name: Andersen, Peter Munch
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: ALS
subject: DDC 610 / Medicine & health
subject: Neurogenetics
subject: Amyotrophic Lateral Sclerosis
subject: Motor Neuron Disease
subject: Myatrophische Lateralsklerose
subject: Neurogenetik

description: ObjectiveThe only identified cause of amyotrophic lateral sclerosis (ALS) are mutations in a number of genes found in familial cases but also in sporadic cases. De novo mutations occurring in a parental gonadal cell, in the zygote or postzygotic during embryonal development can result in an apparently sporadic/isolated case of ALS later in life. We searched for de novo mutations in SOD1 as a cause of ALS.MethodsWe analysed peripheral-blood exome, genome and Sanger sequencing to identify deleterious mutations in SOD1 in 4000 ALS patients from Germany, South Korea and Sweden. Parental kinship was confirmed using highly polymorphic microsatellite markers across the genome. Medical genealogical and clinical data were reviewed and compared with the literature.ResultsWe identified four sporadic ALS cases with de novo mutations in SOD1. They aggregate in hot-spot codons earlier found mutated in familial cases. Their phenotypes match closely what has earlier been reported in familial cases with pathogenic mutations in SOD1. We also encountered familial cases where de novo mutational events in recent generations may have been involved.ConclusionsDe novo mutations are a cause of sporadic ALS and may also be underpinning smaller families with few affected ALS cases. It was not possible to ascertain if the origin of the de novo mutations was parental germline, zygotic or postzygotic during embryonal development. All ALS patients should be offered genetic counselling and genetic screening, the challenges of variant interpretation do not outweigh the potential benefits including earlier confirmed diagnosis and possible bespoken therapy.
Bleomycin and other bioactive compounds: chemical studies and production
Creators: name: Hart, Noel
Publisher: name: Swinburne
Year: 2024

description: This thesis for the degree of Doctor of Philosophy by publication is based on a series of published manuscripts on the anti-cancer agent bleomycin and related compounds that the candidate coauthored while employed in the CSIRO.

A large number of known and new bleomycins and phleomycins were produced by Dr Hart, for studies on the amplification of their antibiotic and antitumor activities by caffeine and other compounds. The benefits of enhancing the activity of anticancer drugs by compounds that alone have no anticancer activity, was considered by other researchers to be “one of the most promising routes of rational design of such drugs”. This unique collection of compounds was also used in studies of factors that produce lung fibrosis in some patients being treated with bleomycin.

The ultimate benefit to society from this work has been the establishment by Dr Hart of the Australian manufacture of the anticancer agent bleomycin sulphate for the world market, using the processes he had developed to make these compounds.
Visual filling-in and surface property reconstruction
Creators: name: Neumann, Heiko
name: Pessoa, Luiz
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: DDC 004 / Data processing & computer science
subject: Brightness perception
subject: Image processing
subject: Information display systems
subject: Computervision

description: We study the problem of the reconstruction of achromatic surface properties, namely brightness. We show that the filling-in of brightness through a diffusion process can be linked to the general framework of feature reconstruction through regularization theory that is widely used in computer vision. In particular, it will be shown that brightness filling-in is a means of reconstructing smooth information from local contrast data that minimizes first order derivative information. Our investigation provides a formal link between modeling perceptual data for biological vision and the mathematical frameworks of regularization and linear spatially variant diffusion. The present analysis of filling-in also suggests a new diffusion mechanism that effectively employs confidence information. Simulations on psychophysical stimuli illustrate the mechanism´s potential.
Electrical tuning of three-dimensional photonic crystals using polymer dispersed liquid crystals
Creators: name: McPhail, Dennis K.
name: Straub, Martin H.
name: Gu, Min
Publisher: name: Swinburne
Year: 2024

description: Electrically tunable three-dimensional photonic crystals with a tunable wavelength range of over 70 nm of stop gaps between 3 and 4 µm have been generated in a liquid crystal-polymer composite. The photonic crystals were fabricated by femtosecond-laser direct writing of void channels in an inverse woodpile configuration with 20 layers providing an extinction of infrared light transmission of 70% in the stacking direction. Stable structures could be manufactured up to a liquid crystal concentration of 24%. Applying a direct voltage of several hundred volts in the stacking direction of the photonic crystal changes the alignment of the liquid crystal directors and hence the average refractive index of the structure. This mechanism permits the direct tuning of the photonic stop gap.
Graphene as a piezo-resistive coating to enable strain monitoring in glass fiber composites
Creators: name: Reghat, Mojdeh
name: Mirabedini, Azadeh
name: Tan, Adin
name: Weizman, Udi
name: Middendorf, Peter
name: Bjekovic, Robert
name: Hyde, Lachlan
name: Antiohos, Dennis
name: Hameed, Nishar
name: Fuss, Franz
name: Fox, Bronwyn
Publisher: name: Swinburne
Year: 2024

description: In this study, the electromechanical properties and strain monitoring behavior of graphene-coated glass fiber reinforced epoxy (GGFRE) composites were investigated. Glass fabrics were first coated with 2 wt% graphene dispersions using a blade coating method and composites of these graphene-coated glass fabrics were manufactured using vacuum resin infusion. As-prepared GGFRE showed an increase in normalized resistance (ΔR/R0) by 4.46%, 10.5%, 11.07% and 11.27% proportional to the applied cyclic tensile forces up to 2000N, 3000N, 4000N and 5000N, respectively. The corresponding gauge factors were calculated to be 14.56 ± 1, 13.32 ± 1, 11.23 ± 0.5 and 8.69 ± 2, respectively. It was also observed that under cyclic tensile loadings at 2000N, ΔR/R0 values were consistent within 11 cycles indicating a reliable sensing performance. The integration of graphene into the composite has shown to decrease the tensile strength as well as flexural strength and flexural modulus by 26%, 37% and 39%, respectively. This drop is believed to be caused by the lower fiber volume content in the GGFRE compared to that of the neat glass fiber composite and the ineffective interfacial interaction between the glass fiber and the graphene dispersion. The piezo-resistive behavior indicated by GGFRE along with their scalable manufacturing method suggest them as promising potential candidates for strain sensing applications.
Uni Ulm intern - das Ulmer Universitätsmagazin, Nr. 237 (30. Jg.), Mai 2000
Creators: name: (:Unkn) Unknown
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: Uni Ulm intern
subject: Universities; Germany; Ulm
subject: Ulm / Universität

description: N/A
Konzept der akademischen Ausbildung am Bundeswehrkrankenhaus Ulm
Creators: name: Claußsnitzer, Christian
name: Friemert, Benedikt
name: Grobecker, Susanne
name: Gümbel, Herman
name: Häfner, Simon
name: Hoffmann, Ralf
name: Kulla, Martin
name: Lampl, Lorenz
name: Lorenz, Kai
name: Martinschek, Andreas
name: Mauer, Uwe
name: Metrikat, Jens
name: Sparwasser, Christoph
name: Tisch, Matthias
name: Wilde, Frank
Publisher: name: Universität Ulm
Year: 2018
Subjects: subject: Lehre
subject: PJ
subject: Humanmedizin
subject: Studium
subject: Kurrikulum
subject: DDC 610 / Medicine & health
subject: Education, medical, graduate; Germany
subject: Praktisches Jahr
subject: Medizinstudium
subject: Curriculum

description: Das Manuskript "Konzept der akademischen Ausbildung am Bundeswehrkrankenhaus Ulm" dient der Information der Studierenden im Praktischen Jahr. Es enthält eine Übersicht der klinischen Abteilungen des Bundeswehrkrankenhauses Ulm sowie deren Ausbildungskonzepte und Ansprechpartner. Es wird im jährlichen Rhythmus überarbeitet und im A5 Format gedruckt. (Auflage ca. 150 Exemplare/Jahr)
"Giorgionismus" in Raffael Sanzios "La scuola di Atene", 1508 - 10, Fresko in der Stanza della Segnatura des Vatikan
Creators: name: Keim, Frank
Publisher: name: Universität Ulm
Year: 2016
Subjects: subject: Ariston
subject: Democritus
subject: Giorgionismus
subject: Heraclitus
subject: Pythagoreer
subject: Zeno
subject: DDC 500 / Natural sciences & mathematics
subject: Archimedes
subject: Aristarchus
subject: Cleanthes
subject: Giorgione / t.Drei Philosophen
subject: Kopernikus, Nikolaus
subject: Philolaos
subject: Pythagoras
subject: Raffaello / t.Die Schule von Athen
subject: Raffaello
subject: Theano

description: Zusammenfassung: Ich vertrete die These, dass Raffael mit seiner "Schule von Athen" von 1508 - 10 ganz in der Tradition des "Giorgionismus" steht. Giorgiones "Die drei Philosophen" von 1508/09 stellen gewissermaßen ein Urbild der "Schule von Athen" dar. Den Schlüssel zum Verständnis der beiden Gruppen auf der rechten Seite des Freskos liefert die Erkennung des Aristarchus von Samos. Er und die Pythagoräer waren die Wegbereiter eines Kopernikus, der in der "Schule" mit Raffael auf der Schwelle zur Neuzeit steht. Neben ihnen wird der Pythagoräer Philolaus von Kroton und der Stoiker Kleanthes zum ersten Mal vollgültig erkannt. Abstract: I advocate the thesis that Raffael with his "School of Athens" (1508 - 10) stands in the tradition of "Giorgionism" entirely. Giorgione’s painting "The three philosophers" of 1508/09 is so to speak one prototype of the "School of Athens". Recognizing Aristarchos of Samos in the fresco gives us the key to understanding the both groups on the right side. He and the Pythagoreans paved the way for Copernicus, who stands in the "School" with Raffael on the threshold to the Modern Age. Furthermore, Philolaus of Croton and the stoic Cleanthes are recognized clearly for the first time.
Integration of spatial PD-L1 expression with the tumor immune microenvironment outperforms standard PD-L1 scoring in outcome prediction of urothelial cancer patients
Creators: name: Weyerer, Veronika
name: Strissel, Pamela L.
name: Strick, Reiner
name: Sikic, Danijel
name: Geppert, Carol I.
name: Bertz, Simone
name: Lange, Fabienne
name: Taubert, Helge
name: Wach, Sven
name: Breyer, Johannes
name: Bolenz, Christian
name: Erben, Philipp
name: Schmitz-Draeger, Bernd J.
name: Wullich, Bernd
name: Hartmann, Arndt
name: Eckstein, Markus
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: urothelial cancer
subject: immune phenotypes
subject: PD-L1
subject: PD-1
subject: TILs
subject: Atezolizumab
subject: Death-ligand 1
subject: DDC 610 / Medicine & health
subject: Bladder; Cancer
subject: Urinary bladder neoplasms; Drug therapy
subject: Immunotherapy
subject: Antineoplastic agents; Therapeutic use
subject: Lymphocytes, Tumor-infiltrating
subject: Programmed cell death 1 receptor
subject: Blasenkrebs
subject: Urothelkrebs
subject: Chemotherapie
subject: Immuntherapie

description: Background: Immune therapy has gained significant importance in managing urothelial cancer. The value of PD-L1 remains a matter of controversy, thus requiring an in-depth analysis of its biological and clinical relevance. Methods: A total of 193 tumors of muscle-invasive bladder cancer patients (MIBC) were assessed with four PD-L1 assays. PD-L1 scoring results were correlated with data from a comprehensive digital-spatial immune-profiling panel using descriptive statistics, hierarchical clustering and uni-/multivariable survival analyses. Results: PD-L1 scoring algorithms are heterogeneous (agreements from 63.1% to 87.7%), and stems from different constellations of immune and tumor cells (IC/TC). While Ventana IC5% algorithm identifies tumors with high inflammation and favorable baseline prognosis, CPS10 and the TCarea25%/ICarea25% algorithm identify tumors with TC and IC expression. Spatially organized immune phenotypes, which correlate either with high PD-L1 IC expression and favorable prognosis or constitutive PD-L1 TC expression and poor baseline prognosis, cannot be resolved properly by PD-L1 algorithms. PD-L1 negative tumors with relevant immune infiltration can be detected by sTILs scoring on HE slides and digital CD8+ scoring. Conclusions: Contemporary PD-L1 scoring algorithms are not sufficient to resolve spatially distributed MIBC immune phenotypes and their clinical implications. A more comprehensive view of immune phenotypes along with the integration of spatial PD-L1 expression on IC and TC is necessary in order to stratify patients for ICI.
Improving the risk assessment of pesticides through the integration of Human Biomonitoring and Food Monitoring Data: a case study for chlorpyrifos
Creators: name: Tarazona, Jose V.
name: González-Caballero, Maria Carmen
name: Kolossa-Gehring, Marike
name: Alba-Gonzalez, Mercedes De
name: Weber, Till
Publisher: name: My University
Year: 2022
Subjects: Human-Biomonitoring
Chlorpyrifos

description: The risk assessment of pesticide residues in food is a key priority in the area of food safety. Most jurisdictions have implemented pre-marketing authorization processes, which are supported by prospective risk assessments. These prospective assessments estimate the expected residue levels in food combining results from residue trials, resembling the pesticide use patterns, with food consumption patterns, according to internationally agreed procedures. In addition, jurisdictions such as the European Union (EU) have implemented large monitoring programs, measuring actual pesticide residue levels in food, and are supporting large-scale human biomonitoring programs for confirming the actual exposure levels and potential risk for consumers. The organophosphate insecticide chlorpyrifos offers an interesting case study, as in the last decade, its acceptable daily intake (ADI) has been reduced several times following risk assessments by the European Food Safety Authority (EFSA). This process has been linked to significant reductions in the use authorized in the EU, reducing consumers exposure progressively, until the final ban in 2020, accompanied by setting all EU maximum residue levels (MRL) in food at the default value of 0.01 mg/kg. We present a comparison of estimates of the consumerââą Ìs internal exposure to chlorpyrifos based on the urinary marker 3,5,6-trichloro-2-pyridinol (TCPy), using two sources of monitoring data: monitoring of the food chain from the EU program and biomonitoring of European citizens from the HB4EU project, supported by a literature search. Both methods confirmed a drastic reduction in exposure levels from 2016 onwards. The margin of exposure approach is then used for conducting retrospective risk assessments at different time points, considering the evolution of our understanding of chlorpyrifos toxicity, as well as of exposure levels in EU consumers following the regulatory decisions. Concerns are presented using a color code, and have been identified for almost all studies, particularly for the highest exposed group, but at different levels, reaching the maximum level, red code, for children in Cyprus and Israel. The assessment uncertainties are highlighted and integrated in the identification of levels of concern. © 2022 by the authors.
BEFRIENding for Depression, Anxiety and Social support in older adults living in Australian residential aged care facilities (BEFRIENDAS): randomised controlled trial protocol
Creators: name: Doyle, Colleen
name: Bhar, Sunil
name: Bryant, Christina
name: Dow, Briony
name: Dunt, David
name: Mnatzaganian, George
name: O’Connor, Daniel
name: Ratcliffe, Julie
name: You, Emily
name: Bagnall, Anne Marie
name: Major, Georgia
name: Harper, Robin
name: Fearn, Marcia
Publisher: name: Swinburne
Year: 2024

description: Background This protocol describes an ongoing study of the impact of befriending on depression, anxiety and loneliness in older people living in residential aged care facilities in Australia. While systematic reviews of befriending have indicated positive benefits of befriending for people in a range of ages and settings, there have been no randomised controlled trials (RCTs) of befriending for older people living in residential aged care with depression and no studies of the cost effectiveness of befriending in residential aged care facilities (RACFs) in Australia. Methods and analysis We are conducting a single blind pragmatic RCT comparing two groups of older people living in RACFs, one receiving an intervention consisting of weekly befriending for 4 months from a trained volunteer and the other receiving treatment as usual. Participants undergo eligibility screening for depression (GDS-15 ≥ 4) and cognitive impairment (GPCog ≥ 4) and assessments at three measurement time points: baseline prior to randomisation, 2 months post-baseline and 4 months post-baseline. The primary outcome measure is depression, and secondary outcome measures are anxiety, loneliness, social isolation and quality of life. The economic evaluation will take the form of a cost-utility analysis based on the outcome of quality of life. The primary and secondary outcomes will be analysed using negative binomial and logistic regressions utilizing the Generalised Estimating Equations approach. Discussion To our knowledge, this is the first RCT evaluating the effectiveness of befriending on older people with depression living in residential aged care. It is expected that the befriending intervention will reduce the severity of depression symptoms experienced by older people living in residential aged care. If the intervention proves effective it may be incorporated into volunteer training programs and adopted as a way of supporting older people’s mental health. Trial registration Trial registered with the Australian and New Zealand Clinical Trial Registry (ANZCTR) Number: ACTRN12619000676112, registered 06/05/2019 – retrospectively registered.
Differential effects of IFN-beta-1b on alpha-beta vs. gamma-delta T cells: An investigation of activation, proliferation and activation-induced apoptosis.
Creators: name: Stone, Julianne Elizabeth.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Health Sciences, Pharmacology.

description: $\alpha\beta$ and $\gamma\delta$ T cells are both postulated to play a role in the pathogenesis of Multiple Sclerosis (MS). IFN-$\beta$-1b (Betaseron), a novel treatment for MS, can change the natural course of MS disease, though its exact mechanism of action is unknown. Since any benefit probably involves effects of IFN-$\beta$-1b on $\alpha\beta$ or $\gamma\delta$ T cells, I derived T cells from MS patients and healthy controls and investigated the effects of IFN-$\beta$-1b on their activation, proliferation and activation-induced apoptosis. PHA, anti-CD3 and tetanus toxoid were used as stimulants for one or both T cell types in the presence of 0-1000 IU/mL IFN-$\beta$-1b. Results indicate that IFN-$\beta$-1b differentially affects $\alpha\beta$ and $\gamma\delta$ T cells both in terms of activation and apoptosis, and that MS cells exhibit differential sensitivity to these effects compared to controls. (Abstract shortened by UMI.)
The harmonized model of entrepreneurial process: 32 into one will go
Creators: name: Hindle, Kevin
Publisher: name: Swinburne
Year: 2024

description: This paper is, effectively, a ‘short version’ of an article now published as: Hindle, K. (2010a). Skillful dreaming: testing a general model of entrepreneurial process with a specific narrative of venture creation. Entrepreneurial Narrative: Theory, Ethnomethodology and Reflexivity. Vol. 1, 97-136. The study offers the field a parsimonious but comprehensive model of entrepreneurial process that incorporates the best features while eliminating the worst elements of the 32 extant entrepreneurial process models now competing for research scholars’ attention. The harmonized MEP emphasises evaluation (the investigation of opportunity resulting in a viable business model), commitment (to implementation) and management (of implementation) as the three key components of entrepreneurial process. The harmonized model embraces the arguments embodied in all 32 extant entrepreneurial models in the literature, as examined by Moroz and Hindle (forthcoming). In particular a ‘harmonizing’ model has the capacity to recognize and reconcile the claims of the causal (Shane and Venkataraman 2000), effectual (Sarasvathy 2001) and bricolage (Baker and Nelson 2005) approaches to understanding entrepreneurial process not as contending logics, but as contingent, contextually defined logics of venture creation.
Reading in L1, L2, and FL: A variable-treatment study.
Creators: name: Zerhouni, Badia.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Language, Linguistics.

description: The present study investigated the effects of four independent variables on free immediate recall of four texts: (1) background knowledge, (2) the global structure of the texts, (3) the propositional structure of the texts, and (4) subjects' second/foreign language proficiency level. Two texts, Text F and Text M discussed topics related to humanities; the other two, Text S and Text E, discussed topics related to science. The four texts had each a different global structure, and were divided into four propositional levels. Three linguistic groups were involved in the study: (1) L1 group (Canadian anglophones), (2) L2 group (Canadian francophones), and (3) FL (Iranian, Serbian, and Moroccan learners of English as a second/foreign language). The three groups consisted of both humanities and science subjects. They were all university students either at the graduate or undergraduate level. The major findings of the present study are as follows: (1) Background knowledge was, to a considerable extent, a determining factor in comprehension and recall of information by subjects, but interest in and motivation for the topic/content of reading were also important factors. (2) Global structure of the texts did not seem to have any determining effects on comprehension and recall of information. Subjects who identified the correct global structure of the texts did not yield different recalls from those who did not identify the correct structure, or those who did not provide a structure at all. Also, there did not seem to be any important interactions between the type of global structure and the topic of the text. (3) Propositional structure produced a variety of significant results. Results of all the groups combined for each of the texts used in the study indicated respect of the hierarchy principle. However, analysis of results at the paragraph level of each text indicated that propositional recall was not always consistent with the hierarchy principle. This analysis also indicated some effects of the serial position principle. (4) Language proficiency also yielded somewhat mixed results. On the one hand, it was shown to be a determining factor in comprehension and recall of information in that higher proficiency levels performed better than lower ones, and L1 and L2 were both superior to FL. On the other hand, it was shown that there were cases of nonsignificant differences between higher and lower proficiency levels, and between L1, L2, and FL. There were also occurrences of superior performances among L2 and FL subjects over L1 subjects.
Methodologies for Estimating Bioaccessibility of Six Metals in Household Dust: Zn, Pb, Cd, Cu, Ni, and Cr
Creators: name: Boros, Kristina
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Household dust
Dust
Soil
NIST
Bioaccessibility
Trace Metals

description: The purpose of this study is to evaluate the relative advantages and disadvantages of two approaches for estimating oral bioaccessibility using a physiologically-based extraction technique (PBET): a simple gastric phase simulation and a two-phase gastrointestinal simulation. Bioaccessibility estimates of six metals prevalent in Canadian contaminated sites (zinc, lead, cadmium, copper, nickel, and chromium) were compared using the gastric phase simulation alone and the complete gastrointestinal simulation. Samples included vacuum dust samples from 33 homes, certified dust and soil reference materials, and a house dust control sample. Bioaccessibility measurements using the gastric phase simulation were greater than or equal to measurements obtained using the gastrointestinal simulation for the six studied metals. This research found that for the six studied metals, a simple simulation of the gastric phase provides the most conservative and cost-effective approach for estimating oral bioaccessibility of ingested metals.
International Cycling Conference 2017
Creators: name: Grafl, Katherina
name: Schulz, Christoph
Publisher: name: My University
Year: 2019
Subjects: subject: Nachhaltige Mobilität
subject: Zufußgehen
subject: Radfahren
subject: Mobilitätskultur
subject: Siedlungsfläche
subject: cycling
subject: sustainable mobility
subject: Transport

description: Die International Cycling Conference (ICC) ist eine interdisziplinäre und internationale Konferenz des Umweltbundesamtes (UBA). Zusammen mit unseren Partnern von PASTA (Physical Activity through Sustainable Transport Approaches) und THE PEP (Transport, Health and Environment Pan-European Programme) sowie der Stadt Mannheim, ECF, Difu und GIZ ist die ICC eine dreitägige Veranstaltung, die die Rolle der aktiven Mobilität aus internationaler Perspektive herausstellt. Im Mittelpunkt der Veranstaltung stehen Synergien in den Bereichen Verkehrsplanung, Gesundheitsfürsorge, Umweltqualität, wirtschaftliche Entwicklung sowie soziale Fragen und vor allem Wissens- und Erfahrungsaustausch zwischen Forschung und Praxis. Quelle: Forschungsbericht
description: 19.-21. September, Mannheim/Germany The International Cycling Conference (ICC) is an interdisciplinary and international conference organized by the German Environment Agency (UBA). Together with our partners from PASTA (Physical Activity through Sustainable Transport Approaches) and THE PEP (Transport, Health and Environment Pan-European Programme) as well as the City of Mannheim, ECF, Difu and GIZ, the ICC is a three-day event organized to highlight the role of active mobility from an international perspective. The event will focus on synergies in transport planning, health care, environmental quality, economic and business development, as well as social issues and above all the exchange of knowledge and experience from research to practice and vice versa. Quelle: Forschungsbericht
description: The Conference Proceedings are the final report of the International Cycling Conference (ICC) which took place from 19 until 21 September 2017 in Mannheim, Germany. Marking the 200th birthday of the bicycle this interdisciplinary and international three-day conference by the German Environment Agency emphasized the importance of cycling from an international perspective. 292 participants, 90 presenters and nearly 50 poster presentations focussed on the synergies between transport planning, health care, environmental quality, economic and business development as well as social issues and above all the exchange of knowledge and experience between research and practice. The audience of the conference and also this publication are researchers, practitioners, political representatives at all levels, NGOs, transport planners, specialist doctors for public health, designers, architects and engineers.
Lattice dynamics of diamond on the basis of Cochran's model.
Creators: name: Blanchard, Robert.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1966
Subjects: subject: Physics, Atomic.

description: In the present thesis we have investigated the lattice dynamics of diamond on the basis of the Cochran version of the dipole approximation model. Results have been presented for the dispersion curves, vibration spectra and Debye temperatures of diamond. We have also obtained the vibration spectra and Debye temperatures of germanium.
Intraspecific Fine-Root Trait-Environment Relationships across Interior Douglas-Fir Forests of Western Canada
Creators: name: Defrenne, Camille E.
name: McCormack, M. Luke
name: Roach, W. Jean
name: Addo-Danso, Shalom D.
name: Simard, S. (Suzanne)
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: Variation in resource acquisition strategies enables plants to adapt to different environments and may partly determine their responses to climate change. However, little is known about how belowground plant traits vary across climate and soil gradients. Focusing on interior Douglas-fir (Pseudotsuga menziesii var. glauca) in western Canada, we tested whether fine-root traits relate to the environment at the intraspecific level. We quantified the variation in commonly measured functional root traits (morphological, chemical, and architectural traits) among the first three fine-root orders (i.e., absorptive fine roots) and across biogeographic gradients in climate and soil factors. Moderate but consistent trait-environment linkages occurred across populations of Douglas-fir, despite high levels of within-site variation. Shifts in morphological traits across regions were decoupled from those in chemical traits. Fine roots in colder/drier climates were characterized by a lower tissue density, higher specific area, larger diameter, and lower carbon-to-nitrogen ratio than those in warmer/wetter climates. Our results showed that Douglas-fir fine roots do not rely on adjustments in architectural traits to adapt rooting strategies in different environments. Intraspecific fine-root adjustments at the regional scale do not fit along a single axis of root economic strategy and are concordant with an increase in root acquisitive potential in colder/drier environments.
Strategic and financial planning in growth and survival oriented small firms
Creators: name: Syrja, Pasi
name: Puumalainen, Kaisu
name: Sjogren, Helena
Publisher: name: Swinburne
Year: 2024

description: Business planning plays a crucial role in small firm’s growth and survival. Small firms need a formal, sophisticated financial and strategic planning. Past studies that examined successful small firms have also pointed out, that well-developed, soundly implemented, and properly controlled planning processes contribute to a firm’s success and to sales growth in particular. This paper aims to contribute to the existing knowledge of small business management in the following ways: firstly, we show how owner-managers growth and survival orientation affects to the length of planning horizon, budgeting and management accounting practices. Secondly, we examine the relationships between the contexts of firm’s financial performance to these managerial practices.
Supplementary Material
Creators: name: Fischer, Lea
name: Maier, Manuel
name: Dingenouts, Nico
name: Hirschberg, Valerian
name: Wittemann, Alexander
name: Fuchs, Matthias
name: Wilhelm, Manfred
Publisher: name: AIP Publishing
Year: 2024
Subjects: classificationCode: 34
subject: Chemical sciences
subject: FOS: Chemical sciences

description: Supplementary Material to Nonlinear Rheological Behavior of Glass-Forming Colloidal Suspensions under Oscillatory Shear: Experiment and Relation to Mode Coupling Theory Predictions
title: Transparency of Legislative Procedures and Access to Acts of Trilogues: Case T-540/15, De Capitani v. European Parliament
Creators: name: Martines, Francesca
Publisher: name: European Papers (www.europeanpapers.eu)
Year: 2018
Subjects: subject: legislative procedure
subject: trilogues
subject: access to acts of the EU institutions
subject: transparency
subject: Regulation (EC) 1049/2001
subject: decision-making process

description: European Papers - A Journal on Law and Integration, 2018 3(2), 947-959
description: European Forum Insight of 24 June 2018
description: I. Introduction. - II. The judgment. - II.1. Factual background. - II.2. The findings of the General Court. - III. Concluding remarks.
description: On 22 March 2018, for the first time the General Court ruled on access to documents of trilogues (case T-540/15, De Capitani v. European Parliament). These are informal meetings between representatives of the European Parliament, the Council and the Commission, which negotiate to reach an agreement, which must subsequently be approved by those institutions in accordance with their respective internal procedures. The judgment, delivered on the appeal made against a refusal by the European Parliament to grant access to the fourth column of the multicolumn table used in an on-going trilogue, confirms that access to documents produced in the legislative procedure can be denied only if the institution requested proves that it is reasonably foreseeable, and not purely hypothetical, that full access to the documents at issue is likely to undermine, specifically and actually, its decision-making process. The General Court considered that the principles of publicity and transparency are to be applied to trilogues, since they constitute a decisive stage in the legislative process, and that exceptions provided for in the regulation regarding public access to European Parliament, Council and Commission documents shall be restrictively interpreted. The judgment represents an important step towards reinforcing transparency of trilogues and democratic legislative process in the EU.
Boden des Jahres 2019
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2018
Subjects: subject: Boden des Jahres 2019
subject: Boden | Fläche

description: Kippenböden sind junge Böden, die sich innerhalb von Jahrzehnten in Bergbaufolgelandschaften entwickelt haben. Sie entstehen aus verkipptem Abraum. Sie sind besonders in den großen Braunkohletagebau-Revieren verbreitet. In der deutschen Bodenklassifikation zählen diese Böden zur Klasse der Terrestrischen Rohböden und zur Klasse der Ah/C-Böden. Die verbreiteten Kipp-Regosole sind aus carbonatfreiem bis carbonatarmem Lockermaterial hervorgegangen. International (WRB) sind sie den Regosols zugeordnet, oder wenn stark sandig, den Arenosols.
A Narratological Analysis of the Life of Aaron
Creators: name: Marincak, Lucas
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: narratology
hagiography
coptic
coptology
classics
classical studies

description: This thesis analyzes the narratological structure of the Life of Aaron, a hagiographical text from Late Antique Egypt. Such an analysis has not yet been performed on this text, and the method is still rarely applied to hagiographical literature. In the short term, I intend for this thesis to expose the complex yet consistent structure of this fascinating text. In the long term, I see this thesis as part of a broader movement to incorporate Coptology into the mainstream study of Late Antique literature. My general introduction discusses the Life of Aaron, its manuscript and archaeological evidence, and the state of scholarship on it. Following this, my first chapter compares the text to five significant Late Antique hagiographical works from Egypt: the Life of Antony, the Life of Pachomius, the Historia Monachorum in Aegypto, the Life of Onnophrius, and the Life of Shenoute. My second chapter surveys the ancient (Aristotelian) and modern (structuralist) narratological methods employed in this thesis. Finally, my third chapter contrasts the Life of Aaron’s literal structure with its underlying chronology - what narratologists call the fabula - and exposes the story’s narrator hierarchy. An epilogue then proposes avenues for future research, and the thesis closes with two short appendix graphs which summarize my analysis.
The trouble with aluminium
Creators: name: Brooks, Geoffrey
Publisher: name: Swinburne
Year: 2024

description: The Australian aluminium industry is in the doldrums. A high dollar, low prices and Asian competition are threatening the industry, with older plants in New South Wales and Victoria under threat of closure. The debate about the future of the industry often concentrates on the high energy usage associated with aluminium production. The joke description of aluminium as 'congealed electricity' is never far away.
MPEC 2025-J51 : 2025 JP1
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2025
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2025 JP1

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Du conditionnel dans les propositions hypothétiques en si : cet intrus.
Creators: name: LeBlanc, Carmen L.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Language, Linguistics.

description: La présente thèse de Maîtrise porte sur la variation de surface entre les formes du conditionnel et celles de l'indicatif dans la protase des propositions hypothétiques en si , dans un corpus du français parlé. L'étude permet de mettre en relief la valeur sociolinguistique de la variable de même que la nuance de sens apportée par le réalignement des formes morphosyntaxique en fonction des distinctions sémantiques véhiculées par l'énoncé. Cette thèse se divise en cinq chapitres. Le chapitre I présente une définition du contexte et de la variable à l'étude. Le chapitre II traite de la méthodologie et le chapitre III est consacré à l'historique des hypothétiques en si depuis le latin. Les chapitres IV et V présentent l'analyse empirique des données en fonction des facteurs internes et externes à la langue. Finalement, une discussion qui résume les résultats de la recherche et les conclusions qui peuvent en être tirées clôt l'étude.