cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: coupe C1a (Barrier  Luginbühl 2021)
Creators: name: Barrier, Sylvie
name: Luginbühl, Thierry
Publisher: name: Conservatoire National des Données 3D (CND3D)
Year: 2024
Subjects: subject: coupe
subject: Artefact
subject: ACQUISITION

description: Modèle 3D
Role of autophagy, SQSTM1, SH3GLB1, and TRIM63 in the turnover of nicotinic acetylcholine receptors
Creators: name: Muzamil Majid Khan
name: Strack, Siegfried
name: Wild, Franziska
name: Hanashima, Akira
name: Gasch, Alexander
name: Brohm, Kathrin
name: Reischl, Markus
name: Carnio, Silvia
name: Labeit, Dittmar
name: Sandri, Marco
name: Labeit, Siegfried
name: Rudolf, Rüdiger
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified

description: Removal of ubiquitinated targets by autophagosomes can be mediated by receptor molecules, like SQSTM1, in a mechanism referred to as selective autophagy. While cytoplasmic protein aggregates, mitochondria, and bacteria are the best-known targets of selective autophagy, their role in the turnover of membrane receptors is scarce. We here showed that fasting-induced wasting of skeletal muscle involves remodeling of the neuromuscular junction (NMJ) by increasing the turnover of muscle-type CHRN (cholinergic receptor, nicotinic/nicotinic acetylcholine receptor) in a TRIM63-dependent manner. Notably, this process implied enhanced production of endo/lysosomal carriers of CHRN, which also contained the membrane remodeler SH3GLB1, the E3 ubiquitin ligase, TRIM63, and the selective autophagy receptor SQSTM1. Furthermore, these vesicles were surrounded by the autophagic marker MAP1LC3A in an ATG7-dependent fashion, and some of them were also positive for the lysosomal marker, LAMP1. While the amount of vesicles containing endocytosed CHRN strongly augmented in the absence of ATG7 as well as upon denervation as a model for long-term atrophy, denervation-induced increase in autophagic CHRN vesicles was completely blunted in the absence of TRIM63. On a similar note, in trim63−/− mice denervation-induced upregulation of SQSTM1 and LC3-II was abolished and endogenous SQSTM1 did not colocalize with CHRN vesicles as it did in the wild type. SQSTM1 and LC3-II coprecipitated with surface-labeled/endocytosed CHRN and SQSTM1 overexpression significantly induced CHRN vesicle formation. Taken together, our data suggested that selective autophagy regulates the basal and atrophy-induced turnover of the pentameric transmembrane protein, CHRN, and that TRIM63, together with SH3GLB1 and SQSTM1 regulate this process.
title: Dissecting the Determinants of Domain Insertion Tolerance and Allostery in Proteins
Creators: name: Mathony, Jan
name: Aschenbrenner, Sabine
name: Becker, Philipp
name: Niopek, Dominik
Publisher: name: Wiley-VCH
Year: 2024

description: Domain insertion engineering is a promising approach to recombine the functions of evolutionarily unrelated proteins. Insertion of light‐switchable receptor domains into a selected effector protein, for instance, can yield allosteric effectors with light‐dependent activity. However, the parameters that determine domain insertion tolerance and allostery are poorly understood. Here, an unbiased screen is used to systematically assess the domain insertion permissibility of several evolutionary unrelated proteins. Training machine learning models on the resulting data allow to dissect features informative for domain insertion tolerance and revealed sequence conservation statistics as the strongest indicators of suitable insertion sites. Finally, extending the experimental pipeline toward the identification of switchable hybrids results in opto‐chemogenetic derivatives of the transcription factor AraC that function as single‐protein Boolean logic gates. The study reveals determinants of domain insertion tolerance and yielded multimodally switchable proteins with unique functional properties.
title: 02_0296
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
EASY TEACHING AND LEARNING STRATEGIES IN PRIMARY SCHOOL.
Creators: name: Sobirova, Noila
name: Rajapova, Malika
Publisher: name: Zenodo
Year: 2024

description: Teaching and learning are crucial part of social life as well as they are not easy matters. In the globalization period, teaching foreign language is becoming essential and it requires strategies in order to make the lessons effective. This article covers some theories by linguists and other scientists about how to teach easily children in primary school, that is, children from 7 to 10 years old, and their learning.
title: Investigating Delay in Health Related Decision Making Versus Non-Health Decision Making
Creators: name: Edwards, Ann Lassiter
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 2009

description: Health and non-health decision domains were examined to explore the differences in decision domain and delay preferences. Using an existing cognitive theory of delay (Bastardi & Shafir, 1998; Tykocinski & Ruffle, 2003), type of scenario (health vs. nonhealth) was manipulated within subjects with participants receiving three scenarios of each type. Certainty (certain vs. uncertain) and delay choice condition (no delay, delay, one-week delay) were manipulated between subjects. This resulted in a 2 (health) X 2 (certainty) X 3 (delay choice) split-plot factorial design. The dependent measure was the proportion of action responses (deciding to change status quo) across the three scenarios. More people made active decisions in health related decisions than in non-health related decisions (p & .001). When given the opportunity to delay, significantly less people chose to make an active decision (p & .001) regardless of decision domain. There was no significant difference in the amount of delay (one day or one week).
RETRAIT DES PAYS DE L'AES DE LA CEDEAO : Analyse théorique des conséquences macroéconomiques
Creators: name: Etienne Fakaba Sissoko
name: Tahirou TANGARA
name: Khalid DEMBELE
Publisher: name: Zenodo
Year: 2024

description: Cette étude examine les conséquences économiques théorique, politiques et sociales du retrait des pays de l'Alliance des États du Sahel (AES) - Mali, Burkina Faso et Niger - de la CEDEAO. Utilisant une méthodologie mixte, nous avons combiné l'analyse quantitative à travers des Modèles d'Équilibre Général Calculable (MEGC), le modèle de Solow-Swan et la théorie keynésienne, avec une enquête qualitative incluant 30 interviews d'experts. Nos résultats révèlent que le retrait a eu des impacts négatifs sur le commerce, l'investissement et la demande globale dans ces pays, exacerbant les défis économiques et sociaux existants. Malgré des signes de résilience dans certains secteurs, comme l'or et les télécommunications au Mali, les incertitudes politiques et les sanctions économiques continuent de peser lourdement. Notre étude contribue à la littérature en fournissant une analyse approfondie des répercussions macroéconomiques et socio-politiques du retrait de la CEDEAO, mettant en lumière les défis et opportunités pour les politiques économiques et la gouvernance dans la région du Sahel.
Hypoxia-induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway
Creators: name: Wan, Gang
name: Weidong Xie
name: Zhenyan Liu
name: Xu, Wei
name: Yuanzhi Lao
name: Huang, Nunu
name: Cui, Kai
name: Meijian Liao
name: He, Jie
name: Yuyang Jiang
name: Yang, Burton B
name: Hongxi Xu
name: Naihan Xu
name: Yaou Zhang
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Cancer

description: Hypoxia activates autophagy, an evolutionarily conserved cellular catabolic process. Dysfunction in the autophagy pathway has been implicated in an increasing number of human diseases, including cancer. Hypoxia induces upregulation of a specific set of microRNAs (miRNAs) in a variety of cell types. Here, we describe hypoxia-induced MIR155 as a potent inducer of autophagy. Enforced expression of MIR155 increases autophagic activity in human nasopharyngeal cancer and cervical cancer cells. Knocking down endogenous MIR155 inhibits hypoxia-induced autophagy. We demonstrated that MIR155 targets multiple players in MTOR signaling, including RHEB, RICTOR, and RPS6KB2. MIR155 suppresses target-gene expression by directly interacting with their 3′ untranslated regions (UTRs), mutations of the binding sites abolish their MIR155 responsiveness. Furthermore, by downregulating MTOR signaling, MIR155 also attenuates cell proliferation and induces G1/S cell cycle arrest. Collectively, these data present a new role for MIR155 as a key regulator of autophagy via dysregulation of MTOR pathway.
Q6, a novel hypoxia-targeted drug, regulates hypoxia-inducible factor signaling via an autophagy-dependent mechanism in hepatocellular carcinoma
Creators: name: Liu, Xiao-Wen
name: Cai, Tian-Yu
name: Zhu, Hong
name: Cao, Ji
name: Su, Yi
name: Yong-Zhou Hu
name: Qiao-Jun He
name: Yang, Bo
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Cancer
subject: Computational Biology

description: Tumor hypoxia underlies treatment failure and yields more aggressive and metastatic cancer phenotypes. Although therapeutically targeting these hypoxic environments has been proposed for many years, to date no approaches have shown the therapeutic value to gain regulatory approval. Here, we demonstrated that a novel hypoxia-activated prodrug, Q6, exhibits potent antiproliferative efficacy under hypoxic conditions and induces caspase-dependent apoptosis in 2 hepatocellular carcinoma (HCC) cell lines, with no obvious toxicity being detected in 2 normal liver cell lines. Treatment with Q6 markedly downregulated HIF1A [hypoxia inducible factor 1, α subunit (basic helix-loop-helix transcription factor)] expression and transcription of the downstream target gene, VEGFA (vascular endothelial growth factor A). This dual hypoxia-targeted modulation mechanism leads to high potency in suppressing tumor growth and vascularization in 2 in vivo models. Intriguingly, it is the autophagy-dependent degradation pathway that plays a crucial role in Q6-induced attenuation of HIF1A expression, rather than the proteasome-dependent pathway, which is normally regarded as the predominant mechanism underlying posttranslational regulation of HIF1A. Inhibition of autophagy, either by short interfering RNA (siRNA) or by chemical inhibitors, blocked Q6-induced HIF1A degradation. Autophagic degradation of HIF1A was further confirmed by the observation that HIF1A coimmunoprecipitated with the ubiquitin-binding adaptor protein, SQSTM1, which is degraded through autophagy. Additionally, silencing of SQSTM1 inhibited Q6-induced HIF1A degradation. These findings suggest that the novel hypoxia-targeted agent, Q6, has potential clinical value in the therapy of HCC. Furthermore, the identification of autophagy as a crucial regulator of HIF1A provides new insights into hypoxia-related treatments.
title: Hold Me in a Circle of Tender Listening: Listening-with an oral history archive of women's psychiatric experience to create a multi-channel sound work
Creators: name: McDowell, Amanda
Publisher: name: University of Kent
Year: 2024

description: This practice research explores five women’s recordings from the Mental Health Testimony Archive (British Library and Mental Health Media 1999/2000), an archive fifty oral history testimonies recorded in 1999 and 2000.1 Working solely with the audio from these testimonies, I have developed methods for listening -with survivors of psychiatry in order to create a polyvocal, multichannel sound installation that enables encounters -with women who have been systematically silenced. I started this project from a position of lived experience and have used my embodied entanglement to engage the affective and haunted registers of women’s testimonial recordings. Working with sound, in all of its ephemerality and permeability, this research brings women out of their archival isolation and into dialogue with each other. Through practices of listening-with and compositioning I have engaged with the spoken and the unspoken, the non-narrativizable and paralinguistic qualities of voice, both human and non-human, such as the sounds of a constantly moving tongue, a fax machine beeping and a page being turned, in order to activate and stage an archive, creating new assemblages of listening. The research traverses a number of disciplines including voice and sound studies, listening and oral history. It engages with transgenerational haunting, demonstrating how twentieth century psychiatry continues to haunt the present, including current psychiatric practices— 1 The Mental Health Testimony Archive is available to view in the British Library, catalogue number C905. ii Abstract iii affecting bodies and crossing spatial and temporal borders, through diasporic voices and media technologies. It asserts that psychiatry, which considers itself a listening profession, has often failed to listen, and asks questions about recovery narratives and oral history as projects for capturing life stories. Completing this research at time when both the mental health of the UK population and mental health services are deemed by many to be in crisis (MIND 2023; Mahasep 2023) the work makes an important contribution to conversations about psychiatry’s past, present and future. It shows how testimony never represents simply a record of the past, but rather deepens the historical present in ways that can be felt. The research develops new, embodied methods for listening-with, not in order to assimilate or ‘know’ the other, but in ways that accept uncertainty, being-with, side-by-side, listening and relating in ways that can be transformative. In the end, I hope that audiences of this work, will take the opportunity to reflect on women’s experiences of psychiatry in ways that might lead them to consider how things could be different.
title: Introduction_Les éditions d'art de la Librairie des amateurs
Creators: name: AmateurS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021

description: Introduction
description: ID_PARA_00947
Label-free detection and dynamic monitoring of drug-induced intracellular vesicle formation enabled using a 2-dimensional matched filter
Creators: name: Obaid Aftab
name: Fryknäs, Mårten
name: Xiaonan Zhang
name: Milito, Angelo De
name: Hammerling, Ulf
name: Linder, Stig
name: Larsson, Rolf
name: Gustafsson, Mats G
Publisher: name: Taylor & Francis
Year: 2016
Subjects: Biophysics
Biochemistry
Space Science
Medicine
Cell Biology
Pharmacology
Cancer
Computational Biology

description: Analysis of vesicle formation and degradation is a central issue in autophagy research and microscopy imaging is revolutionizing the study of such dynamic events inside living cells. A limiting factor is the need for labeling techniques that are labor intensive, expensive, and not always completely reliable. To enable label-free analyses we introduced a generic computational algorithm, the label-free vesicle detector (LFVD), which relies on a matched filter designed to identify circular vesicles within cells using only phase-contrast microscopy images. First, the usefulness of the LFVD is illustrated by presenting successful detections of autophagy modulating drugs found by analyzing the human colorectal carcinoma cell line HCT116 exposed to each substance among 1266 pharmacologically active compounds. Some top hits were characterized with respect to their activity as autophagy modulators using independent in vitro labeling of acidic organelles, detection of LC3-II protein, and analysis of the autophagic flux. Selected detection results for 2 additional cell lines (DLD1 and RKO) demonstrate the generality of the method. In a second experiment, label-free monitoring of dose-dependent vesicle formation kinetics is demonstrated by recorded detection of vesicles over time at different drug concentrations. In conclusion, label-free detection and dynamic monitoring of vesicle formation during autophagy is enabled using the LFVD approach introduced.
STUDIO CLINICO_KETO NAFLD 460.2020
Creators: name: IRCCS MultiMedica - Data Management
Publisher: name: Zenodo
Year: 2024

description: STUDIO CLINICO_ KETO NAFLD 460.2020

TITOLO : Studio per valutare gli effetti della chirurgia metabolico-bariatrica sulla capacità chetogenica in soggetti con obesità e steatosi epatica non alcolica (Keto-NAFLD)

Promotore: MultiMedica con Fondi EFSD

Studio osservazionale prospettico monocentrico

Sinossi Versione 1.0  del 4/11/2020 - Verbale CE 2.2021 e 18.2021
COMPARISON OF LEFT VENTRICULAR MYOCARDIAL MASS ACCORDING TO ECHOCARDIOGRAPHY AND ELECTROCARDIOGRAPHY
Creators: name: Madjidova, G.T.
name: Sunnatova, G.I.
name: Mardiev, A.
Publisher: name: Zenodo
Year: 2024

description: A comparison was made of the myocardial mass of the left ventricle of the heart (LVMM), calculated from echocardiography , unaveraged and averaged ECG data, and the effectiveness of these methods in identifying the dynamics of LVMM during antihypertensive therapy in patients was assessed.
title: bol B12a (Barrier  Luginbühl 2021)
Creators: name: Bibracte
Publisher: name: Conservatoire National des Données 3D (CND3D)
Year: 2024
Subjects: subject: bol

description: Bol (grand) refermé  à profil sinueux curviligne  bord déversé  carène parcourue par des cannelures
title: How Do People Perceive MNCs? Development and Validation of a Multidimensional Attitudes towards MNCs Scale
Creators: name: Zhang, Shuojia
Publisher: name: The Australian National University
Year: 2024

description: This research program investigates host nationals' attitudes towards multinational corporations (MNCs) and their antecedents and consequences. MNCs have rapidly expanded worldwide. As external agents, MNCs inevitably bring different cultures, values and styles of governance into host countries. Such differences can influence members of the general public' attitudes towards MNCs (ATM). These attitudes can have significant consequences for MNCs in host countries regarding talent attraction and retention, stakeholder relationships and consumer choices, ultimately leading to financial viability of MNCs. However, there is little known about host nationals' ATM. Through three studies, this research program creates and validates a scale on individuals' ATM in host nations. I conduct this research in the context of China. China is one of the largest recipients of foreign direct investment (FDI), with MNC units from various countries. Hence, China serves as an excellent context to study ATM. Study 1 is inductive (interviews, N = 55) and helps identify general and specific attitudes towards MNCs. This study's findings also help generate items for each scale component. Then, Study 2 validates the scale in three steps: 1/ item generation, item reduction and external content validation; 2/ psychometric properties; and 3/ nomological network validity assessment at seven multiple time points through survey research based on ten separate samples (N = 1404). Finally, Study 3 undertakes empirical research (i.e., multiple time points, two survey-based studies) with 691 participants to apply the ATM Scale developed in Study 2 to test the proposed models described in Study 1 (abductively developed based on the literature and the inductive study) in a recruitment context. As a point of clarification, the present study comprehensively investigates host nationals' ATM as a whole, rather than individual MNCs, without considering heterogeneity of MNCs, such as the nature of FDI, country of origin or specific sector. When referring to 'host nationals', this research program does not distinguish them based on demographics, including educational background, residential location or the nature of their profession or work experience. The three studies collectively contribute to the attitudes, international business and management theory literature. This research program makes three contributions to the attitudes literature by providing a tool to measure ATM. Then, the study contributes to organisational attraction as well as legitimacy of MNCs in the host location. Last, it introduces a new informal institution, ATM, contributing to signalling and institutional theory. The research program has practical implications for managers and practitioners. It helps understand ATM, which may in turn aid in comprehending corporate image, marketing strategy, MNC employee training programs and recruitment in the host context.
Untangling the link between political regime and economic growth: a multidimensional analysis through a recent systematic literature review
Creators: name: Merwan AATANY
name: Essaid TARBALOUTI
Publisher: name: Zenodo
Year: 2024

description: The complex relationship between political regime and economic development has sparked intense debate across disciplines. While some argue for the efficiency of authoritarian regimes in fostering economic growth, others emphasize the necessity of political and economic freedoms. This paper conducts a thorough literature review to explore recent research on the impact of authoritarian and democratic regimes on economic growth.

With enduring scholarly and policy interest, the study aims to discern whether democratic or authoritarian regimes are more conducive to economic growth and to identify the underlying mechanisms. It also investigates the roles of political and economic freedoms in promoting sustained and inclusive economic progress. Adopting a multidimensional approach, the research seeks to uncover the intricate links between economic growth and political regime. By integrating existing knowledge and recent research, it provides crucial insights into the complex interactions between economics and politics, enriching understanding of the diverse impacts of political regimes on economic development.
title: bol B12a (Barrier  Luginbühl 2021)
Creators: name: Luginbühl, Thierry
name: Barrier, Sylvie
Publisher: name: Conservatoire National des Données 3D (CND3D)
Year: 2024
Subjects: subject: bol
subject: Artefact
subject: ACQUISITION

description: Modèle 3D
title: Sensitive Detection of a Gaseous Analyte with Low‐Power Metal–Organic Framework Functionalized Carbon Nanotube Transistors
Creators: name: Kumar, Sandeep
name: Dehm, Simone
name: Wieland, Laura
name: Chandresh, Abhinav
name: Heinke, Lars
name: Flavel, Benjamin S.
name: Krupke, Ralph
Publisher: name: Wiley-VCH
Year: 2024

description: A highly sensitive and low‐power sensing platform for detecting ethanol molecules by interfacing high‐purity, large‐diameter semiconducting carbon nanotube transistors with a metal–organic framework layer is presented. The new devices outperform similar graphene‐based metal–organic framework devices by several orders of magnitude in terms of sensitivity and power consumption, and can detect extremely low ethanol concentrations down to sub‐ppb levels while consuming only picowatts of power. The exceptional sensor performance results from the nanotube transistor's high on/off ratio and its sensitivity to charges, allowing for ultra‐low power consumption. The platform can also compensate for shifts in threshold voltage induced by ambient conditions, making it suitable for use in humid air. This novel concept of MOF/CNTFETs could be customized for detecting various gaseous analytes, leading to a range of ultra‐sensitive and ultra‐low power sensors.
title: Oral History (english version)
Creators: name: Althaus, Andrea
name: Apel, Linde
Publisher: name: ZZF - Leibniz-Zentrum für Zeithistorische Forschung: Docupedia-Zeitgeschichte
Year: 2024
Subjects: subject: 901 Geschichtsphilosophie, Geschichtstheorie

description: Oral history has been enriching the theoretical and methodological debates of German-language contemporary history research for over forty years. While early skepticism towards oral history has long since given way to its broad (and sometimes uncritical) acceptance and application, there is still much debate about what exactly it is as both a method and a research field, and what value for historiography – and as source material – it has. In our contribution to the debate, we explore how oral history has developed over time, which international and interdisciplinary influences have proven significant, its underlying theoretical and methodological concepts, and which factors might shape its future.
Strukturen in additiv gefertigten Wärmeübertragern — Parameterbasierte Generierung und messtechnische Charakterisierung innerer Gitterstrukturen zur Verbesserung des Wärmeübergangs
Creators: name: Kahlfeld, Robin
name: Meyer, Ina
name: Messmann, Cameron
name: Lachmayer, Jasper
name: Thies, Niklas
name: Ehlers, Tobias
name: Lachmayer, Roland
name: Kabelac, Stephan
Publisher: name: Hannover : Deutscher Kälte- und Klimatechnischer Verein e.V.
Year: 2023
Subjects: subject: Wärmeübertrager
subject: Gitterstrukturen
subject: Additive Fertigung
subject: Pulverbettbasiertes Schmelzen von Metallen mittels Laserstrahl (PBF-LB/M)
subject: Konferenzschrift
subject: Dewey Decimal Classification::600 | Technik

description: Das pulverbettbasierte Schmelzen von Metallen mittels Laserstrahl (PBF-LB/M) ermöglicht als additives Fertigungsverfahren neuartige, hocheffiziente Wärmeübertrager mit komplexen inneren Strukturen. Ein Ansatz zur Steigerung der volumetrischen thermischen Leistungsdichte sind dabei Lattice Structures, Gitterstrukturen aus periodischen Einheitszellen. Zur thermofluiddynamischen Optimierung kann eine Vielzahl von Parametern angepasst werden. Dies erfordert eine grundlegende Untersuchung der Auswirkung der Parametervariationen. Die Generierung solcher Strukturen erfolgt über eine skriptbasierte Konstruktionsumgebung. Im folgenden Beitrag werden drei unterschiedlich ausgerichtete Diamond-Lattice-Structures generiert und messtechnisch charakterisiert. Der Algorithmus zur Generierung wird beschrieben. Die Strukturen unterscheiden sich bezüglich Anordnung und Ausrichtung. Sie sind auf der Gas-Seite eines kompakten, mittels PBF-LB/M gefertigten, Gaskühlers verortet. Wärmeübergang und Druckverlust werden für Leerrohr-Eintritts-Reynolds-Zahlen von 700 bis 9000 vermessen und untereinander sowie mit einem konventionellen, geometrisch ähnlichen Referenz-Rohrbündel verglichen. Die effizienteste Struktur hat gegenüber den beiden anderen um 54 % bzw. 59 % niedrigere mittlere Druckverluste, wobei die Wärmeströme jedoch im Mittel nur um 23 % bzw. 18 % abnehmen. Dies zeigt, dass über Parametervariationen eine deutliche Effizienzsteigerung, also Steigerung des übertragenen Wärmestroms bezogen auf den einhergehenden Druckverlust, möglich ist. Der Rohrbündelwärmeübertrager weist eine durchgehend niedrigere volumetrische Leistungsdichte auf, wobei die auftretenden Druckverluste jedoch ebenfalls geringer ausfallen.
Statin-associated muscle symptoms: position paper from the Luso-Latin American Consortium
Creators: name: Sposito, Andrei C.
name: Neto, José Rocha Faria
name: Luiz Sergio F. De Carvalho
name: Lorenzatti, Alberto
name: Cafferata, Alberto
name: Elikir, Gerardo
name: Esteban, Eduardo
name: Villegas, Enrique C. Morales
name: Luiz Carlos Bodanese
name: Alonso, Rodrigo
name: Ruiz, Alvaro J.
name: Rocha, Viviane Z.
name: Faludi, André A.
name: Xavier, Hermes T.
name: Otávio Rizzi Coelho
name: Assad, Marcelo H.V.
name: Izar, Maria C.
name: Santos, Raul D.
name: Fonseca, Francisco A.H.
name: Silva, Alberto Mello E
name: Silva, Pedro Marques Da
name: Bertolami, Marcelo C.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy

description: In the last two decades, statin therapy has proved to be the most potent isolated therapy for attenuation of cardiovascular risk. Its frequent use has been seen as one of the most important elements for the reduction of cardiovascular mortality in developed countries. However, the recurrent incidence of muscle symptoms in statin users raised the possibility of causal association, leading to a disease entity known as statin associated muscle symptoms (SAMS). Mechanistic studies and clinical trials, specifically designed for the study of SAMS have allowed a deeper understanding of the natural history and accurate incidence. This set of information becomes essential to avoid an unnecessary risk of severe forms of SAMS. At the same time, this concrete understanding of SAMS prevents overdiagnosis and an inadequate suspension of one of the most powerful prevention strategies of our times. In this context, the Luso-Latin American Consortium gathered all available information on the subject and presents them in detail in this document as the basis for the identification and management of SAMS.
The influence of antioxidants in the thiyl radical induced lipid peroxidation and geometrical isomerization in micelles of linoleic acid
Creators: name: Bujak, Ivana Tartaro
name: Mihaljević, Branka
name: Ferreri, Carla
name: Chryssostomos Chatgilialoglu
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: The biomimetic model of micelles of linoleic acid containing 2-mercaptoethanol and the antioxidant was examined under gamma irradiation up to 400 Gy in aerobic or deoxygenated conditions where thiyl radicals are the main reactive species. Lipid peroxidation was retarded by ascorbic acid and α-tocopherol, whereas this process was strongly inhibited by resveratrol as effectively as the ascorbic acid/α-tocopherol mixture. Furthermore, antioxidants have a much stronger inhibitory effect on the peroxidation in the presence of 2-mercaptoethanol, and at the same time show protective properties of the double bond, decreasing the cis–trans isomerization. Under anaerobic conditions, cis–trans isomerization occurred and antioxidants efficiency increased along the series: resveratrol < α-tocopherol
Statin-Associated Muscle Symptoms. Position paper from the Luso-Latin American Consortium
Creators: name: Sposito, Andrei C.
name: Neto, José Rocha Faria
name: Luiz Sergio F De Carvalho
name: Lorenzatti, Alberto
name: Cafferata, Alberto
name: Elikir, Gerardo
name: Esteban, Eduardo
name: Villegas, Enrique C. Morales
name: Luiz Carlos Bodanese
name: Alonso, Rodrigo K.
name: Morales, Alvaro J. Ruiz
name: Rocha, Viviane Z
name: Andre´ A. Faludi
name: Xavier, Hermes T
name: Otávio Rizzi Coelho
name: Assad, Marcelo H.
name: Izar, Maria C.
name: Santos, Raul D.
name: Fonseca, Francisco A. H.
name: Silva, Alberto Mello E
name: Silva, Pedro Marques Da
name: Bertolami, Marcelo C.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy

description: In the last 2 decades, statin therapy has proved to be the most potent isolated therapy for attenuation of cardiovascular risk. Its frequent use has been appointed as one of the most important elements for the reduction of the cardiovascular mortality in developed countries. However, the recurrent incidence of muscle symptoms in statin users raised the possibility of causal association, leading to disease entity known as statin associated muscle symptoms (SAMS). Mechanistic studies and clinical trials, specifically designed for the study of SAMS allowed a deeper understanding of the natural history and the accurate incidence. This set of information becomes essential to avoid an unnecessary risk of severe forms of SAMS. At the same time, this concrete understanding of SAMS prevents overdiagnosis and an inadequate suspension of one of the most powerful prevention strategies of our times. In this context, this Luso-Latin American Consortium gathered all available information on the subject and presents them in detail in this document as the basis for the identification and management of SAMS.
From M-sigma through Gravitational Waves, the Astronomical Unit, and the Transactional Interpretation of Quantum Mechanics to Travel into the Past
Creators: name: Bartlett, Karen
Publisher: name: figshare
Year: 2016
Subjects: subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Astrophysics
subject: 20105 General Relativity and Gravitational Waves
subject: Planetary Science
subject: Solar System, Solar Physics, Planets and Exoplanets
subject: Space Science
subject: 49999 Earth Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 40402 Geodynamics
subject: 40403 Geophysical Fluid Dynamics
subject: Geophysics
subject: 40503 Physical Oceanography
subject: Atmospheric Sciences
subject: 20299 Atomic, Molecular, Nuclear, Particle and Plasma Physics not elsewhere classified
subject: 20303 Fluid Physics
subject: General Relativity
subject: 20202 Nuclear Physics
subject: 20203 Particle Physics
subject: Quantum Mechanics

description: The submission covers several aspects of physics and astronomy and tries to unite them into a comprehensive picture. The main topics are -
M-sigma relationship (between a galaxy's central black hole and the orbiting speeds of stars in the galaxy's bulge), Gravitational waves and geysers on Saturn's moon Enceladus, Gravitational waves and Earth's tides, Astronomical Unit, Isaac Newton, Curvature and Flatness in Space-time, Transactional Interpretation of Quantum Mechanics, non-fundamentalism of Atoms' Nuclear forces, travel into the Past.
For ease of reading, the references are inserted at appropriate positions within the text.
Step by step installation guide of a virtual server for bio-applications from scratch
Creators: name: Abba', Simona
name: Birello, Giancarlo
name: Perin, Anna
name: Ghignone, Stefano
name: Fucile, Ivano
name: Giovanetti, Valter
Publisher: name: figshare
Year: 2016
Subjects: subject: 89999 Information and Computing Sciences not elsewhere classified
subject: FOS: Computer and information sciences

description: Turin-based institutes of the Italian National Research Council (CNR) have been dealing with NGS DATA (Next-gen sequencing) for years, but, until 2012, no CNR-based high-performance server was available. Powerful multi-core servers,clusters and virtual cloud-based machines represent are essential to address the computational demands of
NGS. The IRCrES Institute built up a server for such bio-applications and the joint effort of IPSP and
IRCrES put the basis for a new bioinformatics facility in the CNR Turin Research Area.
Achieve control: a pragmatic clinical trial of insulin glargine 300 U/mL versus other basal insulins in insulin-naïve patients with type 2 diabetes
Creators: name: Oster, Gerry
name: Sullivan, Sean D.
name: Mehul R. Dalal
name: Kazemi, Mahmood R.
name: Rojeski, Maria
name: Wysham, Carol H.
name: Sung, Jennifer
name: Johnstone, Bryan
name: Cali, Anna M.G.
name: L.J. Wei
name: Traylor, Louise
name: Anhalt, Henry
name: Hull, Michelle
name: Vleet, John Van
name: Meneghini, Luigi F.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 60506 Virology
subject: Computational Biology

description: Objective: This study aims to compare the effectiveness of insulin glargine 300 U/mL (Gla-300) with its accompanying patient support program with that of other basal insulin and available patient support programs in patients with type 2 diabetes (T2D) in a real-world setting in terms of achieving HEDIS (Healthcare Effectiveness Data and Information Set) individualized glycemic targets without documented symptomatic hypoglycemia. Methods: Achieve Control is a US-based, multicenter, randomized, open-label, active-controlled, parallel group pragmatic Phase IV trial in insulin-naïve patients with T2D uncontrolled on ≥2 oral antidiabetes drugs (OAD) and/or glucagon-like peptide-1 receptor antagonists (GLP-1 RA). Inclusion criteria include a diagnosis of T2D, age ≥18 years, and glycated hemoglobin (HbA1c) between 8.0% and 11.0%. Patients will be assigned to either the Gla-300 or other basal insulin group. The primary end point is the proportion of patients achieving HEDIS HbA1c targets (<8.0% [64 mmol/mol] in patients with comorbidities or aged ≥65 years; <7.0% [58 mmol/mol] in all other patients) without occurrence of symptomatic hypoglycemia (blood glucose ≤70 mg/dL) from baseline to 6 months. Secondary end points include rates of documented symptomatic nocturnal hypoglycemia and severe hypoglycemia; change from baseline in HbA1c, fasting glucose, and body weight; treatment persistence; patient-reported outcomes; and healthcare resource utilization. Planned enrollment is 3270 patients across approximately 400 clinical sites. Conclusion: Pragmatic clinical trials offer the potential to assess comparative effectiveness in broadly based patient populations receiving care (with or without a corresponding educational support program) in real-world clinical settings. The results of Achieve Control should elucidate the benefits of management of T2D with Gla-300 versus other basal insulins in terms of patient outcomes, experiences, and perceptions, and its impact on healthcare resource utilization and cost. Clinical trial registration: www.clinicaltrials.gov identifier is NCT02451137.
Platelet-derived growth factor-BB attenuates titanium-particle-induced osteolysis in vivo
Creators: name: Chenyi Ye
name: Zhang, Wei
name: Shuai Jiang
name: Yuanbin Yu
name: Xiaoyu Zhou
name: Zhu, Ling
name: Deting Xue
name: Rongxin He
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology

description: Inflammation and osteoclastogenesis play critical roles in wear-particle-induced periprosthetic osteolysis (WPO). Platelet-derived growth factor-BB (PDGF-BB) could promote osteogenesis and inhibit inflammatory response. The aim of this study was to investigate the impact of PDGF-BB on WPO. Mice were divided into four groups, namely, sham, vehicle, low-, and high-dose PDGF-BB groups. Mice in the rhPDGF-BB groups were treated with PDGF-BB at 0.25 or 1 mg/ml/kg/day. Mice in the sham and vehicle groups received PBS daily. Two weeks after surgery, calvariae were harvested. Immunohistochemical analysis and μ-CT showed that PDGF-BB significantly reduced osteoclast formation and bone resorption. ELISA showed that rhPDGF-BB decreased the secretion of TNF-α, IL-1β, and IL-6. Western blotting revealed that rhPDGF-BB stimulated the expression of osteocalcin and osteoprotegerin. Furthermore, more VEGF and CD31 proteins were observed due to PDGF-BB by immunofluorescence. In conclusion, these findings suggest that rhPDGF-BB represents a potential treatment for WPO.
A repository for sharing open research data about plant viruses
Creators: name: Abba', Simona
name: Vallino, Marta
name: Birello, Giancarlo
name: Perin, Anna
name: Caciagli, Piero
Publisher: name: figshare
Year: 2016
Subjects: subject: 60704 Plant Pathology
subject: FOS: Biological sciences

description: Scientists often see the potential offered by Open Research Data, but most are still unready to engage in data archive and curation. One of the main issues that hinders data sharing is related to the lack of incentive mechanisms, both in terms of dedicated budgets and in terms of ready-to-use technical support tools to store, manage and make accessible research data. This situation is detrimental for the scientific community as well as for enterprises and citizens that are supposed to exploit the economic impact of new findings and benefit from the results of publicly-funded research projects, respectively. The project “V2P2 repository” aims at developing a technical solution to ensure a trustworthy e-infrastructure for permanent integrity and re-use of agricultural research data.
Multimorbidity and place: Physical and social neighbourhood features and the development of multiple long-term health conditions
Creators: name: Marshall, Alan
Publisher: name: Zenodo
Year: 2024

description: This presentation shares findings from a work package within the AIM-CISC project at the University of Edinburgh that is using a range of data to explore clustering of multimorbidity in neighbourhood and according to individual characteristics. Among the various characteristics of place that  we consider in this talk, we find that both material neighbourhood deprivation and social aspects of neighbourhoods (such as neighbourhood belonging) each independently predict risk of multimorbidity with loneliness a plausible pathway underpinning associations. Social aspects of place are very much neglected in geodemographic profiles (such as the Index of Multiple Deprivation) and, in response, we present a core contribution of our AIM-CISC work that develops neighbourhood profiles based on themes emerging in geo-referenced local Edinburgh media (newspaper) text data. These themes capture unmeasured aspects of place (such as low-level social disorder) and we will present results that evaluate whether they are useful in predicting and further understanding spatial inequalities in the risks of multimorbidity.
Current practices in the nutrition management of people with amyotrophic lateral sclerosis (ALS): a survey of U.S. ALS care teams
Creators: name: Pearson, Keith
name: Dobak, Stephanie
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: To assess current practices of U.S. professionals providing outpatient ALS nutrition care. A cross-sectional survey assessing nutrition care practices was distributed in February/March 2023 through electronic mailing lists of relevant professional organizations. Of the 87 professionals completing the survey, 85.1% were registered dietitians and 50.6% had five or fewer years of experience in ALS care. Many (44.2%) professionals reported receiving no training on the nutrition care of people with ALS (PALS), and 40.2% reported having no other ALS dietitians in their close network. Methods utilized to estimate calorie and protein requirements in PALS varied widely. Although 95.4% of respondents reported that their clinic’s dietitian participates in feeding tube discussions, many practitioners may be waiting until ALS symptoms negatively impact PALS’ breathing, eating, swallowing, or weight to begin discussing feeding tubes. Additionally, few professionals reported institutional practices conducive for refeeding syndrome prevention or monitoring. Many professionals providing outpatient nutrition care to PALS possess limited experience, received insufficient training, and are not connected to other ALS dietitians. Specific nutrition care practices, including nutrient need estimation, vary widely among health professionals. Practices surrounding feeding tube discussions and refeeding syndrome may be suboptimal at many institutions. These findings highlight the need for initiatives that educate and connect practitioners providing nutrition care to PALS.