cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Safety of indacaterol in the treatment of patients with COPD
Creators: name: Kornmann, Oliver
name: Kramer, Benjamin
name: Donohue, James
name: Singh, Dave
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: PurposePooled data were analyzed to evaluate the safety and tolerability of indacaterol, a once-daily inhaled long-acting β2-agonist for chronic obstructive pulmonary disease (COPD).Patients and methodsData were pooled from clinical studies of 3–12 months’ duration in patients with moderate-to-severe COPD receiving double-blind indacaterol 75 μg (n = 449), 150 μg (n = 2611), 300 μg (n = 1157), or 600 μg once daily (n = 547); formoterol 12 μg twice daily (n = 556); salmeterol 50 μg twice daily (n = 895); placebo (n = 2012); or tiotropium 18 μg once daily, given open label or blinded (n = 1214). Outcomes were adverse events, serious adverse events and deaths, plasma potassium, blood glucose, and QTc interval and vital signs.ResultsThe commonest adverse events with indacaterol were COPD worsening, nasopharyngitis, and headache; most cases were mild or moderate and incidence was generally similar to placebo and other active treatments. The risk of acute respiratory serious adverse events (leading to hospitalization, intubation, or death) was not significantly increased with any of the active treatments compared with placebo. COPD exacerbation rates (analyzed in the intent-to-treat population) were significantly reduced with all active treatments versus placebo. Hazard ratios versus placebo for major cardiovascular adverse events were <1 for all indacaterol doses. Notable values for vital signs and measures of systemic β2-adrenoceptor activity were rare with indacaterol. The number of deaths adjusted per patient-year was lower with indacaterol (all doses combined) than with placebo (relative risk 0.21 [95% confidence interval 0.07–0.660], P = 0.008).ConclusionIndacaterol has a good profile of safety and tolerability that is appropriate for the maintenance treatment of patients with COPD.
Unsupervised Deep Learning for IoT Time Series
Creators: name: Liu, Ya
name: Zhou, Yingjie
name: Yang, Kai
name: Wang, Xin
Publisher: name: arXiv
Year: 2023
Subjects: subject: Machine Learning (cs.LG)
subject: Signal Processing (eess.SP)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: A.1; I.2

description: IoT time series analysis has found numerous applications in a wide variety of areas, ranging from health informatics to network security. Nevertheless, the complex spatial temporal dynamics and high dimensionality of IoT time series make the analysis increasingly challenging. In recent years, the powerful feature extraction and representation learning capabilities of deep learning (DL) have provided an effective means for IoT time series analysis. However, few existing surveys on time series have systematically discussed unsupervised DL-based methods. To fill this void, we investigate unsupervised deep learning for IoT time series, i.e., unsupervised anomaly detection and clustering, under a unified framework. We also discuss the application scenarios, public datasets, existing challenges, and future research directions in this area.
description: 22 pages, 8 figures, has been published by IEEE Internet of Things Journal
Competence development through the lens of structuration - Does age matter in Finnish IT workplaces?
Creators: name: Jallinoja, Niina
Publisher: name: University of Westminster
Year: 2020

description: This thesis is about existing employees’ competence development, with a particular focus on middle-aged and late-career employees in the Finnish information technology field. Research on adult education, workforce development and workplace learning has traditionally relied on economic, psychosocial and learning theories. The lower participation rate of older workers in skills training is explained in terms of lowered abilities and willingness to learn, or through employers’ cost- driven strategies, which prioritise younger employees. While earlier studies tend to focus on either the employee or the learning environment, this thesis emphasises the relationships between an employee’s agency and the enablers and constraints apparent in the work environment. The aim is to understand differences in employees’ participation in competence development activities within the workplace and the significance of various factors involved. A pragmatic ontology is applied and a methodology of mixed methods, integrating data collection and analysis of a structured survey across industries (N=1,119) and face-to-face interviews (N=27). Theoretically, a novel approach is developed by building on key concepts of structuration theory (Giddens, 1979, 1984). The core argument in this thesis is that the frequency of competence development activities is an outcome of the pre-existing interaction between the employee and the learning environment. The thesis contributes to theory by providing an empirically grounded and theoretically informed conceptualisation of employees’ competence development, firstly, in the form of an analytical framework, and secondly, in the novel categorisation of agentic orientations. The thesis proposes that employees engage in competence development activities at different levels as a result of their agentic orientation, which may be proactive, reactive or restricted. Following these orientations, employees perceive factors in the learning environment as either enabling, supportive or constraining, leading to the agentic actions to initiate, accept or reject opportunities for competence development. Empirically, the study demonstrates that late-career employees are as active in their competence development activities as middle-aged employees are but face specific challenges of indirect age discrimination related to on-the-job learning. The holistic framework and the categorisation of proactive, reactive and restricted employees supports policymakers and practitioners to adjust their adult education and training offerings by observing individual agentic orientation rather than chronological age. In addition, these serve to avoid age and gender biases related to on-the-job learning.
Severity of COPD at initial spirometry-confirmed diagnosis: data from medical charts and administrative claims
Creators: name: Saiers, Jane
name: Dalal, Anand
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: PurposeThis study was conducted to determine COPD severity at the time of diagnosis as confirmed by spirometry in patients treated in a US managed care setting.Patients and methodsAll patients with one or more inpatient stays, one or more emergency department visits, or two or more outpatient visits with diagnosis codes for COPD during 1994–2006 were identified from the Lovelace Patient Database. From this group, a subset of continuously enrolled patients with evidence in claims of a first available pulmonary function test or pulmonary clinic visit and a confirmatory claim for a COPD diagnosis was selected. Medical chart abstraction was undertaken for this subset to gather information for diagnosis and severity staging of each patient based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria for COPD.ResultsOf the 12,491 patients with a primary or secondary COPD diagnosis between 1994 and 2006, there were 1520 continuously enrolled patients who comprised the study cohort. Among the 648 eligible records from patients with evidence of a pulmonary function test, 366 were identified by spirometry as having COPD of GOLD stage I or higher (average percentage of predicted forced expiratory volume in 1 second: 60%): 19% were diagnosed at the stage of mild disease (GOLD stage I); 50% at moderate disease (GOLD stage II); and 31% at severe or very severe disease (GOLD stage III or IV, respectively). The majority of patients in these groups were not receiving maintenance treatment.ConclusionThe results demonstrate a very low incidence of early-stage diagnosis, confirmed by a pulmonary function test, of COPD in a large US sample and support calls for increased screening for COPD and treatment upon diagnosis.
Additional file 2 of A novel method for transforming Geobacillus kaustophilus with a chromosomal segment of Bacillus subtilis transferred via pLS20-dependent conjugation
Creators: name: Mori, Kotaro
name: Fukui, Kaho
name: Amatsu, Ryotaro
name: Ishikawa, Shu
name: Verrone, Valeria
name: Wipat, Anil
name: Meijer, Wilfried J. J.
name: Yoshida, Ken-ichi
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2. Standard curves showing quantity of total RNA vs. threshold cycle (Ct) for gk0103 transcript. The total RNA samples were prepared from strains MK244 and MR01 cells grown in the presence (MI +) and absence (MI –) of myo-inositol, and subjected to quantitative RT-PCR analysis to detect the gk0103 transcript. The four standard curves made for the samples are very similar to each other, indicating that the copy number of gk0103 transcript is constant and reliable as the internal control.
Sputtered terbium iron garnet films with perpendicular magnetic anisotropy for spintronic applications
Creators: name: Damerio, Silvia
name: Avci, Can Onur
Publisher: name: arXiv
Year: 2023
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We report the structural, magnetic, and interfacial spin transport properties of epitaxial terbium iron garnet (TbIG) ultrathin films deposited by magnetron sputtering. High crystallinity was achieved by growing the films on gadolinium gallium garnet (GGG) substrates either at high temperature, or at room temperature followed by thermal annealing, above 750 °C in both cases. The films display large perpendicular magnetic anisotropy (PMA) induced by compressive strain, and tunable structural and magnetic properties through growth conditions or the substrate lattice parameter choice. The ferrimagnetic compensation temperature (TM) of selected TbIG films was measured through temperature-dependent anomalous Hall effect (AHE) in Pt/TbIG heterostructures. In the studied films, TM was found to be between 190-225 K, i.e., approximately 25-60 K lower than the bulk value, which is attributed to the combined action of Tb deficiency and oxygen vacancies in the garnet lattice evidenced by x-ray photoelectron spectroscopy measurements. Sputtered TbIG ultrathin films with large PMA and highly tunable properties reported here can provide a suitable material platform for a wide range of spintronic experiments and device applications.
On Cosmological Low Entropy After the Big Bang: Universal Expansion and Nucleosynthesis
Creators: name: Sharpe, Charlie F.
name: Barnes, Luke A.
name: Lewis, Geraint F.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We investigate the sensitivity of a universe's nuclear entropy after Big Bang nucleosynthesis (BBN) to variations in both the baryon-to-photon ratio and the temporal evolution of cosmological expansion. Specifically, we construct counterfactual cosmologies to quantify the degree by which these two parameters must vary from those in our Universe before we observe a substantial change in the degree of fusion, and thus nuclear entropy, during BBN. We find that, while the post-BBN nuclear entropy is indeed linked to baryogenesis and the Universe's expansion history, the requirement of leftover light elements does not place strong constraints on the properties of these two cosmological processes.
description: 15 pages, 5 figures. It has been accepted for publishing but has not yet appeared. The journal is General Relativity and Gravitation
Additional file 1 of Plastome phylogenomics and historical biogeography of aquatic plant genus Hydrocharis (Hydrocharitaceae)
Creators: name: Li, Zhi-Zhong
name: Lehtonen, Samuli
name: Gichira, Andrew W.
name: Martins, Karina
name: Efremov, Andrey
name: Wang, Qing-Feng
name: Chen, Jin-Ming
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Figure S1. Genome alignment of plastomes of Hydrocharis species and Limnobium laevigatum. H. dubia was used as a reference.
Numerische Simulation des Fest-Flüssig-Trennprozesses in Vollmantelzentrifugen: Simulationsmethode und Bestimmung des Materialverhaltens
Creators: name: Hammerich, Simon
Publisher: name: Karlsruhe
Year: 2020
Subjects: Fest-Flüssig-Trennprozess
Vollmantelzentrifuge
Numerische Strömungssimulation
Sediment
Fließverhalten
solid-liquid separation
solid bowl centrifuge
computational fluid dynamics
sediment
rheological behaviour

description: Das Ziel der vorliegenden Arbeit ist die Vorhersage des Fest-Flüssig-Trennprozesses in Röhrenzentrifugen mithilfe von numerischen Strömungssimulationen unter Berücksichtigung des Aufbaus des Sediments und dessen Materialverhalten. Die entwickelte und auf einem vereinfachten Euler/Euler-Ansatz basierende Simulationsmethode ermöglicht zeit- und ortsaufgelöste Simulationen des gesamten Trennprozesses, um für die Prozessauslegung und Prozessoptimierung relevante Kenngrößen mit dem Zustand im Zentrifugenrotor zu verknüpfen. Die experimentelle Charakterisierung des dafür notwendigen Fließverhaltens des Sediments erfolgt mithilfe einer entwickelten Scherzelle für ein Ringschergerät.
Characterization of airway inflammation in patients with COPD using fractional exhaled nitric oxide levels: a pilot study
Creators: name: Herje, Nancy
name: Crater, Glenn
name: Rickard, Kathleen
name: Donohue, James
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: ObjectiveTo characterize fractional exhaled nitric oxide (FeNO) levels that may be indicative of Th2-mediated airway inflammation in patients with chronic obstructive pulmonary disease (COPD).MethodsThis single-visit, outpatient study was conducted in 200 patients aged 40 years and older with COPD. All patients underwent spirometry and FeNO testing. COPD severity was classified according to the Global initiative for chronic Obstructive Lung Disease (GOLD) 2010 guidelines.ResultsPatients who participated in the study had a mean age of 63.9±11.3 years and a mean smoking history of 46±29 pack years. Patients had a mean forced expiratory volume in 1 second % predicted of 53.9%±22.1%. The percentage of patients classified with COPD severity Stage I, II, III, and IV was 13%, 40%, 39%, and 8%, respectively. In addition, according to current procedural terminology codes, 32% of patients were classified as mixed COPD/asthma, 26% as COPD/emphysema, and 42% as all other codes. The mean FeNO level for all patients was 15.3±17.2 parts per billion (ppb). Overall, 89% of patients had a FeNO <25 ppb, 8% had a FeNO 25–50 ppb, and 3% had a FeNO >50 ppb. The percentages of patients with FeNO in the intermediate or high ranges of FeNO were greatest among patients with mixed COPD/asthma (intermediate, 11.5%; high, 6.6%) compared with COPD/emphysema (intermediate, 8%; high, 0) and all other codes (intermediate, 6.3%; high, 1.3%).ConclusionIncreases in FeNO were identified in a subset of patients with COPD, particularly in those previously diagnosed with both COPD and asthma. Since FeNO is useful for identifying patients with airway inflammation who will have a beneficial response to treatment with an inhaled corticosteroid, these data may have important implications for the management of COPD patients.
Abusive head trauma among children in Alaska: a population-based assessment
Creators: name: Baldwin-Johnson, Cathy
name: Goldsmith, Yvonne
name: Volz, Margaret
name: Parrish, Jared
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: BackgroundSerious physical abuse resulting in a traumatic brain injury (TBI) has been implicated as an underreported cause of infant mortality. Nearly 80% of all abusive head trauma (AHT) occurs among children <2 years of age, with infants experiencing an incidence nearly 8 times that of 2-year olds.ObjectiveThis study describes the validation of the CDC Pediatric Abusive Head Trauma (PAHT) definitions when applied to a multi-source database at the state level and provides a robust annual incidence estimate of AHT among children <2 years of age in Alaska.DesignAHT cases among children residing in Alaska during 2005–2010 were identified by applying the PAHT coding schema to a multi-source database which included vital death records, the Violent Death Reporting System (AK-VDRS), the Maternal Infant Mortality Review – Child Death Review (MIMR-CDR), the Alaska Trauma Registry (ATR), the inpatient Hospital Discharge Database (HDD) and Medicaid claims. Using these data, we calculated statewide AHT annual incidence rates.ResultsThe databases with the highest case capture rates were the ATR and Medicaid systems, both at 51%, followed by HDD at 38%. Combined, the ATR, HDD and Medicaid systems captured 91% of all AHT cases. The linkage and use of the PAHT definitions yielded an estimated sensitivity of 91% and specificity of 98%. During the study period, we detected an annual average incidence of 34.4 cases per 100,000 children aged <2 years (95% CI 25.1, 46.1) and a case fatality proportion of 22% (10/45). Among the AHT cases, 82% were infants. Significant differences (p < 0.05) in AHT were noted by age and race, but not by sex.ConclusionsIn Alaska, applying the CDC PAHT definition to the multi-source database enabled us to capture 49% more AHT cases than any of the individual database used in this analysis alone.
Calculation of Electron Swarm Parameters in Ar/H2 and Kr/H2 Mixtures
Creators: name: Mostefaoui, Mohamed
name: Benyoucef, Djilali
name: Taleb, Rachid
name: Gadoum, Abdelatif
Publisher: name: arXiv
Year: 2023
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: To develop the modeling of electrical discharges in a gaseous medium, it must to know a numbers of basic data such as: the electron collision cross sections for particle modeling or the electron swarm parameters in the case of the fluid modeling. The knowledge of all the electron swarm parameters as a function of the reduced electric field is indispensable for the fluid models based on the first and the second moment of the electron energy distribution function. The objective of this work is to calculate the mobility, the characteristic energy, and the ionization coefficient in the case of the mixtures Ar/H2 and Kr/H2. The results obtained will be compared with measurements already made by different authors.
description: 5 pages, 2 figures, conference
The Home
Creators: Mohammad Hossein Abbasi
Publisher: name: University of Alberta Library
Year: 2023

For most of us, the borders of home mean security and a sense of belonging. The home can have a very wide and borderless concept or an architectural structure made of physical and cultural walls. In The Home series, I seek to explore those borders. To find a quintessential structure that best aligns with my concept. As an immigrant, my work seeks to navigate “The Third Space” 1as experienced by diasporic populations.

Composing my structures in pictorial space permits more mystery and illusion. It is a fluid space where distortions like to dwell. These distortions are unique to each of us, defined by our individual and group experiences. Whether from cultural and geographical migrations, or globalization and the technological revolution; these filters affect us all.

Creating artwork is an opportunity for me to embark on an endless journey, where I explore the interplay between my chosen subject and the boundless possibilities offered by painting as a versatile medium with a rich historical background. To me, it is essential to break away from conventional techniques, allowing room for spontaneity and unforeseen events to influence the semiotic and aesthetic essence of the form, all while adhering to the fundamental principles of form and color.

With each series of works in the exhibition, I select simple shapes or images, like houses, boats, or cubic shapes, as a starting point. These objects provide a foundational path upon which I can unleash a flurry of changes, deconstructions, and reconstructions within the image. These shapes or images often have some initial connection to my experiences as a Middle Eastern immigrant. I consistently blend the semiotic and aesthetic meanings of the form in an accidental manner, aiming to strike a delicate balance between subject matter and content. My studio practices, which I undertake frequently and extensively alongside my theoretical studies, hold tremendous significance for me. The process of creating art is as important as the final product since they both provide new insights about the image.
Data and matlab code of figures of GECCO23 paper: https://doi.org/10.1145/3583131.3590451
Creators: name: Schönenberger, Lisa
Publisher: name: Zenodo
Year: 2023

description: This repository contains the code and data of the paper "On a population sizing model for evolution strategies optimizing the highly multimodal rastrigin function." by Schönenberger, Lisa and Beyer, Hans-Georg, in Proceedings of the Genetic and Evolutionary Computation Conference, 2023 (pp. 848-855).
title: Le fromage de colostrum chez les Aït Bouycef
Creators: name: Garaoun, Massinissa
Publisher: name: Pangloss
Year: 2023
Subjects: subject: Linguistique
subject: Tasahlit

description: Précisions dialectales : il s'agit du parler des Aït Bouycef (appelé dans la langue ṯaḇuysefṯ) appartenant à la fraction des Aït Ali Ou Jemaâ. Ce parler est classé parmi les variétés de la tasahlit occidentale
description: Préparation traditionelle du fromage de colostrum chez les Aït Bouycef
Additional file 2 of Plastome phylogenomics and historical biogeography of aquatic plant genus Hydrocharis (Hydrocharitaceae)
Creators: name: Li, Zhi-Zhong
name: Lehtonen, Samuli
name: Gichira, Andrew W.
name: Martins, Karina
name: Efremov, Andrey
name: Wang, Qing-Feng
name: Chen, Jin-Ming
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Figure S2. Nucleotide diversity hotspot regions in plastomes of Hydrocharis species and Limnobium laevigatum.
First discovery of QPOs in the dwarf nova HS 2325+8205 based on TESS photometry
Creators: name: Sun, Qi-Bin
name: Qian, Sheng-Bang
name: Zhu, Li-Ying
name: Dong, Ai-Jun
name: Zhi, Qi-Jun
name: Liao, Wen-Ping
name: Zhao, Er-Gang
name: Han, Zhong-Tao
name: Liu, Wei
name: Zang, Lei
name: Li, Fu-Xing
name: Shi, Xiang-Dong
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: HS 2325+8205 is a long-period eclipsing dwarf nova with an orbital period above the period gap (Porb>3 h) and is reported to be a Z Cam-type dwarf nova. Based on the photometry of the Transiting Exoplanet Survey Satellite (TESS), the light variation and the quasi-periodic oscillation (QPOs) of HS 2325+8205 are studied. Using Continuous Wavelet Transform (CWT), Lomb-Scargle Periodogram (LSP), and sine fitting methods, we find for the first time that there is a QPOs of ~ 2160s in the long outburst top light curves of HS 2325+8205. Moreover, we find that the oscillation intensity of the QPOs of HS 2325+8205 is related to the orbital phase, and the intensity in orbital phases 0.5-0.9 are stronger than in orbital phases 0.1-0.5. Therefore, the relationship between the oscillation intensity of QPOs and the orbital phase may become a research window for the origin of QPOs. In addition, we use the LSP to correct the orbital period of HS 2325+8205 as 0.19433475(6) d.
Additional file 3 of Plastome phylogenomics and historical biogeography of aquatic plant genus Hydrocharis (Hydrocharitaceae)
Creators: name: Li, Zhi-Zhong
name: Lehtonen, Samuli
name: Gichira, Andrew W.
name: Martins, Karina
name: Efremov, Andrey
name: Wang, Qing-Feng
name: Chen, Jin-Ming
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3: Figure S3. Analysis of repeat sequences in plastomes of Hydrocharis species and Limnobium laevigatum. (A) Total number of four repeat types. (B) Number of repeats divided by size.
Pathway to Hope: an indigenous approach to healing child sexual abuse
Creators: name: Parrish, Jared W.
name: Payne, Diane
name: Olson, Kimber
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: BackgroundThe Alaska Native (AN) population has endured multiple historical traumatic events. This population has poorer health outcomes on nearly all factors compared with Alaska non-Natives with more than 75% reportedly being physically assaulted in their lifetime, and child sexual abuse nearly 6 times the national average.ObjectiveThis article describes the Pathway to Hope (PTH) program, which is an indigenous approach to ending silence and denial related to child sexual abuse and encourages multigenerational healing.DesignPTH was developed by ANs who believe that each community is unique, thus strategies for ending denial and support for healing must be woven from the historical context, cultural strengths of individual communities. Strengths-based solutions built on truth, honesty, compassion and shared responsibility for healing and protecting today's children have been profound and successful.The PTH curriculum addresses child sexual abuse from a historical perspective; that the higher rates of sexual abuse among certain Tribes, regions and communities is linked in part to years of victimisation, but may also be perpetuated by internalised oppression and lateral violence among Tribal members.ResultsData suggest that community-based dialogue and wisdom of Native elders and spiritual leaders paired with readiness of community service providers are necessary for sustained change. At all levels, this Indigenous model for learning, sharing, helping and healing brings hope for an end to denial and silence about child sexual abuse for Native people.ConclusionThe PTH program utilises the wisdom and values that have sustained Native people for generations. Ending silence and denial about child sexual abuse and building upon strengths have assisted many Indigenous communities begin the journey toward wellness. Through the PTH, communities have taken steps to accept the challenges associated with establishing safety for children, supporting child victims in healing and to holding offenders accountable.
Fatty acids linked to cardiovascular mortality are associated with risk factors
Creators: name: Ebbesson, Lars O.
name: Umans, Jason G.
name: Wang, Hong
name: Howard, Barbara V.
name: Harris, William S.
name: Fabsitz, Richard R.
name: Weissman, Neil J.
name: Umans, Benjamin D.
name: Kennish, John
name: MacCluer, Jean W.
name: Okin, Peter M.
name: Voruganti, Venkata S.
name: Devereux, Richard B.
name: Laston, Sandra
name: Ebbesson, Sven O. E.
name: Higgins, Paul B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Although saturated fatty acids (FAs) have been linked to cardiovascular mortality, it is not clear whether this outcome is attributable solely to their effects on low-density lipoprotein cholesterol (LDL-C) or whether other risk factors are also associated with FAs. The Western Alaskan Native population, with its rapidly changing lifestyles, shift in diet from unsaturated to saturated fatty acids and dramatic increase in cardiovascular disease (CVD), presents an opportunity to elucidate any associations between specific FAs and known CVD risk factors.
A pilot study of leukocyte expression patterns for drug metabolizing enzyme and transporter transcripts in autoimmune glomerulonephritis
Creators: name: Roberts, Brittney V.
name: Hu, Yichun
name: Joy, Melanie S.
name: Falk, Ronald J.
name: Wang, Jinzhao
name: Hogan, Susan L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Objective: Leukocyte mRNA expression patterns of drug metabolizing enzyme genes and transporter genes that are relevant for the disposition of cyclophosphamide and mycophenolate were studied. The relationships between expression and patient-level data and pharmacokinetics were evaluated. Methods: The study included patients with glomerulonephritis secondary to lupus nephritis (SLE, n = 36), small vessel vasculitis (SVV, n = 35), healthy controls (HC, n = 10), and disease controls (VC, n = 5; LC, n = 5). Transcript assays targeted metabolizing enzymes (UGT1A7, UGT1A9, UGT2B7, CYP3A4, CYP2C9, CYP2B6) and transporters (ABCB1, ABCC2, ABCG2, SLCO1A2). Genotyping for specific variants was conducted. Group transcript fold-changes were evaluated. Patient level data was evaluated for transcript fold-change and disease, treatment, gender, race, and genotype. Results: Significant differences were noted in expression of UGT1A7, ABCB1, and ABCC2; for UGT1A7, SVV (0.17 ± 0.42; p < 0.05) and SLE (0.03 ± 0.1; p < 0.05) groups had lower expression than HC (0.79 ± 2.02). For ABCB1, SLE had a lower expression (0.33 ± 0.21; p < 0.05) than HCs (1 ± 0.82). For ABCG2, SVV group had a lower expression (0.17 ± 0.14; p < 0.05) than HCs (1 ± 1.82). Differences in expression of ABCC2 approached statistical significance with VC patients (2.02 ± 1.13) exhibiting higher expression than SVV patients (1.06 ± 1.11; p = 0.05). The relationships between transcript expression and patient-level data demonstrated; ABCC2 expression was different by race (1.26 ± 1.82 Caucasian versus 1.37 ± 0.86 non-Caucasian; p = 0.049) and CYP2B6 expression was different by treatment (2.07 ± 2.94 cyclophosphamide versus 0.45 ± 0.5 mycophenolate; p = 0.01). Conclusions: The current study showed differential expression of drug metabolizing enzyme and transporter transcripts and contributes to the literature on transcript expression of drug transporters in leukocytes. The implications of altered local metabolism and transport in leukocytes may be important in autoimmune diseases and transplant patients where treatment is targeted to leukocytes.
A healthy bladder: a consensus statement: Consensus statement - a healthy bladder
Creators: name: Palmer, M. H.
name: Gray, M.
name: Sampselle, C.
name: Ellsworth, P.
name: Lukacz, E. S.
name: Rosenberg, M.
name: MacDiarmid, S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: A panel of experts in urology, urogynecology, nursing, and behavioral therapy convened in 2010 to discuss the importance of a healthy bladder on overall health. They determined that a consensus statement was necessary to raise awareness among the general public, healthcare providers, payors, and policymakers, with the goals of minimizing the impact of poor bladder health and stimulating primary prevention of bladder conditions. In this statement, 'healthy' bladder function is described, as well as internal and external factors that influence bladder health. It is suggested that primary prevention strategies should be aimed at providing education regarding normal lower urinary tract structures and functioning to the public, including patients and healthcare providers. This education may promote the achievement of optimal bladder health by increasing healthy bladder habits and behaviors, awareness of risk factors, healthcare seeking, and clinician engagement and reducing stigma and other barriers to treatment. Promoting optimal bladder health may reduce the personal, societal and economic impact of bladder conditions, including anxiety and depression and costs associated with conditions or diseases and their treatment. While adopting healthy bladder habits and behaviors and behaviors may improve or maintain bladder health, it is important to recognize that certain symptoms may indicate the presence of conditions that require medical attention; many bladder conditions are treatable with a range of options for most bladder conditions. Lastly, the authors propose clinical directives based on persuasive and convergent research to improve and maintain bladder health. The authors hope that this statement will lead to promotion and achievement of optimal bladder health, which may improve overall health and help minimize the effects of bladder conditions on the public, healthcare professionals, educators, employers, and payors. The advisors are in consensus regarding the recommendations for improving and maintaining bladder health presented herein.
title: Future Africa?! Timescapes and the Flattening of Time in the Modern Era
Creators: name: Lachenicht, Susanne
name: Institute Of African Studies
name: Bayreuth Academy Of Advanced African Studies
Publisher: name: University of Bayreuth
Year: 2022
Subjects: subject: Future
subject: Time
subject: Coloniality
subject: Early Modern
subject: History
subject: Anthropology
subject: FOS: Sociology
subject: 900

description: This paper critically assesses the making of the modern timescape “the future” from an early modern historian’s and a postcolonial perspective. As a western invention, it was imposed on many societies in the historical contexts of colonialism and imperialism. “The future” is thus loaded with semantics such as ‘civilization versus primitive forms of life’, ‘progress versus backwardness’, ‘development versus regression’ and other similar dichotomies. This article looks into timescapes prevalent in the early modern period, using the latter as a background against which we can reflect on the historical making and baggage of linear timescapes such as the “past, present and future”, about the diversity, or multiplicity, of timescapes in the past and today, how this could inform our understanding of constructions of cultural difference and how much we would need a transperiodical and transregional anthropology of time.
Outcome quantification using SPHARM-PDM toolbox in orthognathic surgery
Creators: name: Paniagua, Beatriz
name: Zhu, HongTu
name: Styner, Martin
name: Cevidanes, Lucia
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Quantification of surgical outcomes in longitudinal studies has led to significant progress in the treatment of dentofacial deformity, both by offering options to patients who might not otherwise have been recommended for treatment and by clarifying the selection of appropriate treatment methods. Most existing surgical treatments have not been assessed in a systematic way. This paper presents the quantification of surgical outcomes in orthognathic surgery via our localized shape analysis framework.
His and her working hours and well-Being in Germany: A longitudinal crossover-spillover analysis
Creators: name: Florean, Daniele
name: Engelhardt, Henriette
Publisher: name: Journal of Family Research
Year: 2020

description: This paper investigates the relationship between work time arrangements and personal well-being in married and cohabiting couples. Using data from the German Socio-Economic Panel Survey (SOEP), we study how the number of hours worked by the survey respondents and their partners influenced their own well-being. We also investigate possible transmission mechanisms between the two variables, namely income, hours spent in homemaking and care activities, and possible mismatch between desired and actual hours. Using Hybrid panel models we find evidence of different relations according to the respondent’s gender: Women report higher satisfaction with the increase of their partner’s working hours, while the opposite is true for men. At the same time, own hours have a positive effect on men’s life satisfaction, while they have the opposite effect for women. The presence of young children in the household further amplifies these results. Our conclusion is that respondents are happier when their and their partner’s behavior conforms to the roles of female homemaker and male breadwinner. Considering the absence of a strong mechanism related to time needs and time desires, we suggest those results are related to strong traditional attitudes towards gender roles and female labor force participation in the country considered.
description: Journal of Family Research, Early View
Calculation of the Electron Swarm Parameters in He/H2 and Ne/H2 Mixtures
Creators: name: Mostefaoui, Mohamed
name: Benyoucef, Djilali
Publisher: name: arXiv
Year: 2023
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: The knowledge of all the electron swarm parameters as a function of the reduced electric field is indispensable for the fluid modeling of electrical discharge at low pressure. In this paper we present the evolution of the swarm parameters as a function of the reduced electric field in the He/H2 and Ne/H2 mixtures. For this we use a BE solver specially designed for this purpose, freely available under the name BOLSIG+, which is more general and easier to use than most other BE available solvers. The solver provides a stable solution state of the BE for the electrons in a uniform electric field, it is based on the conventional two-term approximation. The obtained results are validated through a comparison to experimental swarm parameters already exist in the literature.
description: 7 pages, 2 figures, conference. arXiv admin note: text overlap with arXiv:2302.05786
Additional file 1 of Multicenter study of lumen-apposing metal stents with or without pigtail in endoscopic ultrasound-guided biliary drainage for malignant obstruction—BAMPI TRIAL: an open-label, randomized controlled trial protocol
Creators: name: Garcia-Sumalla, Albert
name: Loras, Carme
name: Sanchiz, Vicente
name: Sanz, Rafael Pedraza
name: Vazquez-Sequeiros, Enrique
name: Aparicio, Jose Ramon
name: de la Serna-Higuera, Carlos
name: Luna-Rodriguez, Daniel
name: Andujar, Xavier
name: Capilla, María
name: Barberá, Tatiana
name: Foruny-Olcina, Jose Ramon
name: Martínez, Belen
name: Dura, Miguel
name: Salord, Silvia
name: Laquente, Berta
name: Tebe, Cristian
name: Videla, Sebastia
name: Perez-Miranda, Manuel
name: Gornals, Joan B.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. SPIRIT checklist.
Additional file 2 of Multicenter study of lumen-apposing metal stents with or without pigtail in endoscopic ultrasound-guided biliary drainage for malignant obstruction—BAMPI TRIAL: an open-label, randomized controlled trial protocol
Creators: name: Garcia-Sumalla, Albert
name: Loras, Carme
name: Sanchiz, Vicente
name: Sanz, Rafael Pedraza
name: Vazquez-Sequeiros, Enrique
name: Aparicio, Jose Ramon
name: de la Serna-Higuera, Carlos
name: Luna-Rodriguez, Daniel
name: Andujar, Xavier
name: Capilla, María
name: Barberá, Tatiana
name: Foruny-Olcina, Jose Ramon
name: Martínez, Belen
name: Dura, Miguel
name: Salord, Silvia
name: Laquente, Berta
name: Tebe, Cristian
name: Videla, Sebastia
name: Perez-Miranda, Manuel
name: Gornals, Joan B.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2. BAMBI Safety definitions
Spatial and temporal patterns of nitrogen deposition in China: Synthesis of observational data
Creators: name: Lu, Chaoqun
name: Tian, Hanqin
Publisher: name: AMER GEOPHYSICAL UNION
Year: 2007
Subjects: TERRESTRIAL CARBON; ACID DEPOSITION; WET DEPOSITION; EASTERN CHINA; AIR-POLLUTION; UNITED-STATES; ASIA; MODEL; PRECIPITATION; EMISSIONS

description: [1] Anthropogenic nitrous pollutant emissions in China significantly increased during the last decades, which contributed to the accelerated nitrogen ( N) deposition. In order to characterize spatial pattern of nitrogen deposition, we employed the kriging technique to interpolate sampling data of precipitation chemistry and ambient air concentration from site-network observations over China. The estimation of wet deposition in China was limited to aqueous NO3- and NH4+, while ambient NO2 was the only species involved in the predicted dry deposition fluxes. To obtain wet deposition fluxes, precipitation concentration was multiplied by 20-year mean precipitation amounts with a resolution of 10 x 10 km. Dry deposition fluxes were products of the interpolated ambient NO2 concentration and deposition velocities modeled for the main vegetation types in China. The total deposition rates of wet and dry deposition peaked over the central south China, with maximum values of 63.53 kg N ha(-1) yr(-1), and an average value of 12.89 kg N ha(-1) yr(-1). With ambient NO2 concentration data spanning from the year 1990 through 2003, we detected and evaluated trends in the time series of the annual values of atmospheric NO2 concentration. Significant upward trends at 21 of 102 sites were exhibited, with median percent change of 61.45% over the period 1990-2003. In addition, spatially continuous patterns of dry deposition fluxes based on ambient NO2 measurements in two 5-year phases, 9 years apart, were carried out. On average, there was a rise of 7.66% in NO2 dry deposition during 9 years throughout China.
Studying the effect of AI Code Generators on Supporting Novice Learners in Introductory Programming
Creators: name: Kazemitabaar, Majeed
name: Chow, Justin
name: Ma, Carl Ka To
name: Ericson, Barbara J.
name: Weintrop, David
name: Grossman, Tovi
Publisher: name: arXiv
Year: 2023
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences

description: AI code generators like OpenAI Codex have the potential to assist novice programmers by generating code from natural language descriptions, however, over-reliance might negatively impact learning and retention. To explore the implications that AI code generators have on introductory programming, we conducted a controlled experiment with 69 novices (ages 10-17). Learners worked on 45 Python code-authoring tasks, for which half of the learners had access to Codex, each followed by a code-modification task. Our results show that using Codex significantly increased code-authoring performance (1.15x increased completion rate and 1.8x higher scores) while not decreasing performance on manual code-modification tasks. Additionally, learners with access to Codex during the training phase performed slightly better on the evaluation post-tests conducted one week later, although this difference did not reach statistical significance. Of interest, learners with higher Scratch pre-test scores performed significantly better on retention post-tests, if they had prior access to Codex.
description: To be published in Proceedings of the 2023 CHI Conference on Human Factors in Computing Systems (CHI '23), April 23--28, 2023, Hamburg, Germany 17 pages with 11 Figures, 2 Tables, 6 Page Appendix
Additional file 5 of Plastome phylogenomics and historical biogeography of aquatic plant genus Hydrocharis (Hydrocharitaceae)
Creators: name: Li, Zhi-Zhong
name: Lehtonen, Samuli
name: Gichira, Andrew W.
name: Martins, Karina
name: Efremov, Andrey
name: Wang, Qing-Feng
name: Chen, Jin-Ming
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 5: Table S2. List of the species downloaded from GenBank and Ross et al. (2016) used for phylogenomic and dating analyses in this study.
CURRENT STATE OF THE PROBLEM OF ACUTE DISORDERS OF CEREBRAL CIRCULATION
Creators: name: Salomova, Nilufar
Publisher: name: Zenodo
Year: 2023

description: at the present stage, more than 50 sources have been studied and systematized to study the problem of acute cerebral circulation.The effectiveness of rehabilitation in patients with cerebral vascular lesions was also studied.However, the data show that this pathology develops rapidly, and their fusion with other pathologies is not enough for the rehabilitation of ONMC.
3D quantification of mandibular asymmetry using the SPHARM-PDM tool box
Creators: name: AlHadidi, Abeer
name: Paniagua, Beatriz
name: Tyndall, Donald
name: Cevidanes, Lucia H.
name: Festy, Frederic
name: Cook, Richard
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Pretreatment diagnosis of mandibular asymmetry in orthognathic surgery patients can be improved by quantitative shape modeling and analysis. The UNC SPHARM-PDM (University of North Carolina Spherical Harmonics—Point Distribution Model) toolbox was applied to a cohort of patients and the results were evaluated.
Soziologische Überlegungen zum Postulat einer Demokratisierung der Kirche
Creators: name: Kaufmann, Franz-Xaver
Publisher: name: Herder Korrespondenz
Year: 1970

description: Herder Korrespondenz, Bd. 26 Nr. 1 (1972): Herder Korrespondenz, Band 26, Heft 1
PGPR: present role, mechanism of action and future prospects along bottlenecks in commercialization
Creators: name: Mushtaq, Zain
Publisher: name: EQA - International Journal of Environmental Quality
Year: 2020
Subjects: PGPR; Plant growth promotion; commercialization; sustainable food production

description: Throughout the plant developmental phases, there exist a strong relationship among soil, plant and rhizosphere microorganisms. The development of strong relationship links with the release of root exudates from plants. Diverse community of soil microorganisms depends on these exudations, establishing a strong interaction from growth promotion to parasitism. PGPR may compete for nutrients against pathogens, produces systematic resistance and antibiotics. They may promote plant growth through phytohormones and solubilizing minerals that affects the plant growth. The biological control of plant diseases through microbial-inoculants have enough potential for a large market share throughout the world, with annual growth-rate of almost 15-20%. The application of microbial based products is an eco-friendly approach and are the most suitable option for reducing the application of chemical fertilizers. The problem with microbial approach comes under field conditions where these microbes have to compete with various biotic and abiotic stresses. Marketing and commercialization are other important factors. However, success of marketing and commercialization is heavily dependent on advancement and improvements in interdisciplinary research, formulation methods, large-scale production, awareness and education of farming community. There is dire need to introduce an integrated approach of microbial based inoculation along with chemical one.
description: EQA - International Journal of Environmental Quality, Vol 41 (2021)
COGNITIVE CHANGES IN PATIENTS WITH CHRONIC KIDNEY DISEASE DEPENDING ON THE DEGREE OF THE DISEASE.
Creators: name: Rakhmatova, D.I.
Publisher: name: Zenodo
Year: 2023

description: 51 patients with CKD were examined, 20 of them with CKD stage I-II (glomerular filtration rate - GFR ≥60 ml/min/1.73 m2, signs of kidney damage), 20 with CKD stage III (GFR 60-30 ml/min/ 1.73 m2), 11 with CKD stage IV (GFR 30-15 ml/min/1.73 m2). A questionnaire was conducted to identify limitations in daily activity, neuropsychological testing was performed using the MMSE scale, a test battery for frontal lobe dysfunction (FAB), and a test to assess regulatory functions. To clarify the etiology of CI, magnetic resonance imaging (MRI) was performed. In patients with chronic renal failure (CKD stages III-IV), cognitive impairment was detected more often than in patients without chronic kidney disease (CKD stages I-II).