cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Differentiating taphonomic features from trampling and dietary microwear, an experimental approach
Creators: name: Micó, Cristian
name: Blasco, Ruth
name: Del Pozo, Alicia Muñoz
name: Jiménez-García, Blanca
name: Rosell, Jordi
name: Rivals, Florent
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Dental microwear is a common and wellestablished technique which allows the short-term reconstruction of the dietary behaviour in extinct and extant vertebrates, allowing inferences about daily, seasonal, or regional variations in diets. However, the use of this method may be limited because taphonomic processes can affect enamel surfaces and modify or obliterate dietary microwear features. Considering the substantial number of agents which can impact the archaeological record, dental microwear alteration processes are poorly known, producing a potential bias in dietary interpretations. In this study, the effect of trampling on dental occlusal surfaces, one of the most common processes recorded in archaeological assemblages, has been experimentally investigated for the first time. The results allowed us to (1) distinguish taphonomic and dietary marks; (2) assess the impacts of trampling on occlusal surfaces; and (3) infer the agents which modified the dental microwear from the teeth obtained from the archaeological sites. The importance of this work lies in the specific guidelines it offers to discriminate trampling marks from microwear features, improving the reliability of dietary interpretations.
Digital Equalization of the electric violin: Method for obtaining violin body impulse response based on machine bowing
Creators: name: Bucci Irwin, Andrés Eduardo
Publisher: name: Zenodo
Year: 2011

description: This work presents a methodology for extracting the violin body impulse response by means of deconvolution of excitation signal coming from an electric violin’s pickup and a recorded audio signal coming from an acoustic violin; both signals are generated automatically by a violin playing machine; therefore, we obtained more acoustic-like sounds coming from the electric instruments. By reviewing the available literature we compared the different approaches to obtain the desired impulse response and determined the specifications for the machine. We provide a detailed description of a prototype for the bowing machine and the physical constraints and limitations in the construction. We also performed a user survey consisting of musically trained and untrained subjects to obtain quantitative information regarding the subjective quality of the obtained sound and to observe if the listeners are able to label the obtained sound as an acoustic instrument.
Supplementary material from Better the devil you know: common terns stay with a previous partner although pair bond duration does not affect breeding output
Creators: name: Rebke, Maren
name: Becker, Peter H.
name: Colchero, Fernando
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 60102 Bioinformatics
subject: FOS: Computer and information sciences
subject: 60801 Animal Behaviour
subject: 10202 Biological Mathematics
subject: FOS: Mathematics

description: Supplementary methods, supplementary discussion, supplementary tables and supplementary figures
title: 01_0071
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Commoning the City in Solidarity with Refugees: A Study of the Exarchea Neighborhood of Athens
Creators: name: Khan, Aiza
Publisher: name: Manara - Qatar Research Repository
Year: 2024
Subjects: classificationCode: 44
subject: Human society

description: This study aims to analyze the refugee solidarity movement in Greece that grew in response to the refugee “crisis” in the 2010s. This movement has offered various forms of support to refugees ranging from housing, medical aid, and food to community and social spaces. This support is offered primarily in squatted buildings. Based on in-depth interviews and participant observation, this dissertation seeks to bring to light the challenges faced by the solidarians in providing continued support to refugees. I argue that the non-hierarchical and inclusive nature of solidarity spaces in the Exarchea neighborhood of Athens embodies Lefebvre’s ideas of citizenship as inhabitance. However, government repression is one of the largest challenges that the movement faces in maintaining its nonhierarchical stance. Solidarity spaces face evictions and police surveillance that make migrants hesitant to actively engage with such spaces. Simultaneously, solidarians experience exhaustion from resisting state violence in their efforts to organize in support of migrants. I also argue that socioeconomic differences, language barriers, and gendered dynamics, as well as gender-based violence, contribute to migrants’ inability to maintain an equal inhabitance of solidarity spaces that are intended to be inclusive.
title: Etched ion-track membranes as tailored separators in Li–S batteries
Creators: name: Lee, Pui Lap Jacob
name: Thangavel, Vigneshwaran
name: Guery, Claude
name: Trautmann, Christina
name: Toimil-Molares, Maria Eugenia
name: Morcrette, Mathieu
Publisher: name: IOP Publishing
Year: 2024

description: Lithium–sulfur (Li–S) batteries are considered a promising next generation alternative to lithium-ion batteries for energy storage systems due to its high energy density. However, several challenges, such as the polysulfide redox shuttle causing self-discharge of the battery, remain unresolved. In this paper, we explore the use of polymer etched ion-track membranes as separators in Li–S batteries to mitigate the redox shuttle effect. Compared to commercial separators, their unique advantages lie in their very narrow pore size distribution, and the possibility to tailor and optimize the density, geometry, and diameter of the nanopores in an independent manner. Various polyethylene terephthalate membranes with diameters between 22 and 198 nm and different porosities were successfully integrated into Li–S coin cells. The reported coulombic efficiency of up to 97% with minor reduction in capacity opens a pathway to potentially address the polysulfide redox shuttle in Li–S batteries using tailored membranes.
Dichiarazione attività reclutamento studio clinico dal titolo: Drenaggio biliare ecoendo-guidato con il posizionamento di EC-LAMS vs ERCP come terapia di prima linea per il trattamento endoscopico di pazienti con ostruzione maligna della via biliare distale
Creators: name: Agnese, valentina
Publisher: name: Zenodo
Year: 2024

description: Per lo studio dal titolo "Drenaggio biliare ecoendo-guidato con il posizionamento di EC-LAMS vs ERCP come terapia di prima linea per il trattamento endoscopico di pazienti con ostruzione maligna della via biliare distale", l'IRCCS ISMETT ha un ruolo di Centro Satellite. 

Si tratta di uno studio no-Pofit promosso dall'Humanitas Research Hospital, approvato dal CE dell'IRCCS ISMETT il 26/02/2020.
Benefícios da Ciência aberta e Open Hardware para o avanço da ciência
Creators: name: Maia Chagas, Andre
Publisher: name: Zenodo
Year: 2024
Subjects: open science
open hardware

description: Presentation slides for a talk given at the Instituto René Rachou (Fiocruz Minas). In it we  have supporting information and data about Open Science, Open Hardware and how they are helping improve research worldwide.
Annexin A8 promotes VEGF-A driven endothelial cell sprouting
Creators: name: Heitzig, Nicole
name: Brinkmann, Benjamin F.
name: Koerdt, Sophia N.
name: Rosso, Gonzalo
name: Shahin, Victor
name: Rescher, Ursula
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Computational Biology

description: The physiological and pathological process of angiogenesis relies on orchestrated endothelial cell (EC) adhesion, migration and formation of new vessels. Here we report that human umbilical vein endothelial cells (HUVECs) deficient in Annexin A8 (AnxA8), a member of the annexin family of Ca2+- and membrane binding proteins, are strongly deficient in their ability to sprout in response to vascular endothelial growth factor (VEGF)-A, and are strongly impaired in their ability to migrate and adhere to β1 integrin-binding extracellular matrix (ECM) proteins. We find that these cells are defective in the formation of complexes containing the tetraspanin CD63, the main VEGF-A receptor VEGFR2, and the β1 integrin subunit, on the cell surface. We observe that upon VEGF-A activation of AnxA8-depleted HUVECs, VEGFR2 internalization is reduced, phosphorylation of VEGFR2 is increased, and the spatial distribution of Tyr577-phosphorylated focal adhesion kinase (pFAK577) is altered. We conclude that AnxA8 affects CD63/VEGFR2/β1 integrin complex formation, leading to hyperactivation of the VEGF-A signal transduction pathway, and severely disturbed VEGF-A-driven angiogenic sprouting.
Investigation of nematocysts in stylasterids (Cnidaria: Hydrozoa: Stylasteridae)
Creators: name: Pica, Daniela
name: Puce, Stefania
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Plant Biology

description: The type, size, shape and distribution of nematocysts represent important taxonomic characters that help to identify many hydrozoan species. The Stylasteridae is one of the most species-rich hydroid families. Nevertheless, information about the soft tissue and especially data about the nematocysts are still very scant. Scattered data about nematocysts are available in several taxonomic papers, but unfortunately without the type identification or shape description, this information is not very useful. Therefore, several questions still need answers. What types of nematocysts are present in the stylasterid family? Do nematocysts have a particular distribution in the soft tissue? Could they be considered a useful taxonomic character for the family? Is it possible to hypothesize their functions? In order to answer these questions, we analysed 15 stylasterid species belonging to seven genera. Euryteles, desmonemes, isorhizas and probably also mastigophores were identified. All examined species have euryteles and desmonemes, while isorhizas are recorded in two genera and mastigophores in only one genus. Moreover, the shape of the nematocysts in some species is very distinct. The distribution of nematocysts shows that each species contains, in the coenosarc, all nematocysts of its cnidome, while in the polyps there are only euryteles and desmonemes. Our study showed that in integrating the information about nematocyst type, size, shape and distribution, each species investigated herein has a specific cnidome. Therefore, nematocysts have a taxonomic value for stylasterids and, whenever possible, nematocysts should be included in the species descriptions. Moreover, the possible functions of stylasterid nematocysts are given in relation to their type and distribution.
Solid lipid nanoparticles for lymphatic delivery.pdf
Creators: name: Mansi Shah
Publisher: name: figshare
Year: 2017
Subjects: subject: 111204 Cancer Therapy (excl. Chemotherapy and Radiation Therapy)
subject: FOS: Clinical medicine
subject: 110299 Cardiorespiratory Medicine and Haematology not elsewhere classified
subject: 111504 Pharmaceutical Sciences

description: Carvedilol-loaded solid lipid nanoparticles (SLNs) were prepared using solubility parameter (δ) to select the lipid, and hot homogenization to fabricate SLNs. The effect of concentration of Compritol 888 ATO (COMP) and Poloxamer 188 (P-188) on the particle size of blank SLNs was studied using the design of experiments. Further narrow concentration range of COMP and P-188 was selected and carvedilol-loaded SLNs were prepared to obtain an optimized formulation which was lyophilized (L-SLNs), transformed into enteric compression-coated tablet and evaluated for drug release, X-ray diffraction and cellular uptake mechanism. COMP was chosen as lipid due to its least value of Δδ with carvedilol. The optimized formulation (7.5% COMP, 5.0% P-188 and 1.11% carvedilol) had 161 nm particle size and 94.8% entrapment efficiency. The enteric-coated carvedilol-loaded SLNs tablet protected carvedilol from acidic environment and similar prolonged release profiles were obtained from L-SLNs, core tablet and enteric-coated tablet. Absence of crystalline carvedilol XRD peak indicated the presence of amorphous carvedilol in SLNs. Higher carvedilol uptake from SLNs compared to drug solution in the Caco-2 cell line exhibited a potential prolonged drug release. Moreover, upon cellular uptake, SLNs could then enter the lymphatic system which will avoid first pass metabolism and hence higher oral bioavailability.
title: Time- and energy-resolved effects in the boron-10 based multi-grid and helium-3 based thermal neutron detectors
Creators: name: Backis, A.
name: Khaplanov, A.
name: Al Jebali, R.
name: Ammer, R.
name: Apostolidis, I.
name: Birch, J.
name: Lai, C. C.
name: Deen, P. P.
name: Etxegarai, M.
name: Ruette, N. de
name: Freita Ramos, J.
name: Förster, D. F.
name: Haettner, E.
name: Hall-Wilton, R.
name: Hamilton, D.
name: Höglund, C.
name: Kadletz, P. M.
name: Kanaki, K.
name: Karnickis, E.
name: Kirstein, O.
name: Kolya, S.
name: Kraujalyte, Z.
name: Laloni, A.
name: Livingston, K.
name: Löhman, O.
name: Maulerova, V.
name: Mauritzon, N.
name: Müller, F.
name: Lopez Higuera, I.
name: Richter, T.
name: Robinson, L.
name: Roth, R.
name: Shetty, M.
name: Taylor, J.
name: Woracek, R.
name: Xiong, W.
Publisher: name: IOP Publishing
Year: 2024

description: The boron-10 based multi-grid detector is being developed as an alternative to helium-3 based neutron detectors. At the European Spallation Source, the detector will be used for time-of-flight neutron spectroscopy at cold to thermal neutron energies. The objective of this work is to investigate fine time- and energy-resolved effects of the Multi-Grid detector, down to a few µeV, while comparing it to the performance of a typical helium-3 tube. Furthermore, it is to characterize differences between the detector technologies in terms of internal scattering, as well as the time reconstruction of ∼ µs short neutron pulses. The data were taken at the Helmholtz Zentrum Berlin, where the Multi-Grid detector and a helium-3 tube were installed at the ESS test beamline, V20. Using a Fermi-chopper, the neutron beam of the reactor was chopped into a few tens of µs wide pulses before reaching the detector, located a few tens of cm downstream. The data of the measurements show an agreement between the derived and calculated neutron detection efficiency curve. The data also provide fine details on the effect of internal scattering, and how it can be reduced. For the first time, the chopper resolution was comparable to the timing resolution of the Multi-Grid detector. This allowed a detailed study of time- and energy resolved effects, as well as a comparison with a typical helium-3 tube.
Use of a hydrophobic associative four-armed star anionic polymer to create a saline aqueous solution of CO2-switchability
Creators: name: Xianwu Jing
name: Zhiyu Huang
name: Hongsheng Lu
name: Baogang Wang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 60506 Virology
subject: Computational Biology

description: A four-armed anionic star-shaped block polymer, containing an anionic polymer poly(2-Acrylamido-2-methylpropanesulfonic acid) (PAMPS) as the core group and poly(2-(Dimethylamino)ethyl methacrylate) (PDM) as the terminal group, was synthesized by using the Atom Transfer Radical Polymerization (ATRP) method. The (PAMPS50-PDM50)4 aqueous solution exhibited both polyelectrolyte and hydrophobic associative characteristics, that is, a low concentration of NaCl results in decreasing viscosity but a high concentration of NaCl results in increasing viscosity. The four-armed anionic block polymer shows a CO2-reversible property at high concentrations of brine. Viscosity, pH, and ζ potential demonstrate the switchability jointly; the values could be switched from relatively low to high cyclically. These transitions could actually be attributed to the protonation of tertiary amine groups in PDM blocks, and the mechanism was proved by 1H NMR.
Use of a Hydrophobic Associative Four-Armed Star Anionic Polymer to Create a Saline Aqueous Solution of CO2-Switchability
Creators: name: Xianwu Jing
name: Zhiyu Huang
name: Hongsheng Lu
name: Baogang Wang
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology
subject: 60506 Virology
subject: Computational Biology

description: A four-armed anionic star shape block polymer, containing an anionic polymer poly(2-Acrylamido-2-methylpropanesulfonic acid) (PAMPS) as the core and poly(2-(Dimethylamino)ethyl methacrylate) (PDM) as the terminal groups, was synthesized by using Atom Transfer Radical Polymerization (ATRP) method. The (PAMPS50-PDM50)4 aqueous solution exhibited both polyelectrolyte and hydrophobic associative characteristics, i.e., low concentration of NaCl results in decreasing of viscosity but high concentration of NaCl increasing of viscosity. The four-armed anionic block polymer shows a CO2 reversible property in high concentration of brine. Viscosity, pH and ζ potential demonstrate the switchability jointly; the values could be switched from relatively low to high cyclically. These transitions could actually be attributed to protonation of tertiary amine groups in PDM blocks, and the mechanism was proved by 1H NMR.
An HP1 isoform-specific feedback mechanism regulates Suv39h1 activity under stress conditions
Creators: name: Raurell-Vila, Helena
name: Bosch-Presegue, Laia
name: Gonzalez, Jessica
name: Kane-Goldsmith, Noriko
name: Casal, Carmen
name: Brown, Jeremy P.
name: Marazuela-Duque, Anna
name: Prim B. Singh
name: Serrano, Lourdes
name: Vaquero, Alejandro
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: The presence of H3K9me3 and heterochromatin protein 1 (HP1) are hallmarks of heterochromatin conserved in eukaryotes. The spreading and maintenance of H3K9me3 is effected by the functional interplay between the H3K9me3-specific histone methyltransferase Suv39h1 and HP1. This interplay is complex in mammals because the three HP1 isoforms, HP1α, β, and γ, are thought to play a redundant role in Suv39h1-dependent deposition of H3K9me3 in pericentric heterochromatin (PCH). Here, we demonstrate that despite this redundancy, HP1α and, to a lesser extent, HP1γ have a closer functional link to Suv39h1, compared to HP1β. HP1α and γ preferentially interact in vivo with Suv39h1, regulate its dynamics in heterochromatin, and increase Suv39h1 protein stability through an inhibition of MDM2-dependent Suv39h1-K87 polyubiquitination. The reverse is also observed, where Suv39h1 increases HP1α stability compared HP1β and γ. The interplay between Suv39h1 and HP1 isoforms appears to be relevant under genotoxic stress. Specifically, loss of HP1α and γ isoforms inhibits the upregulation of Suv39h1 and H3K9me3 that is observed under stress conditions. Reciprocally, Suv39h1 deficiency abrogates stress-dependent upregulation of HP1α and γ, and enhances HP1β levels. Our work defines a specific role for HP1 isoforms in regulating Suv39h1 function under stress via a feedback mechanism that likely regulates heterochromatin formation.
FAIR Data Research with NOMAD and NOMAD Oasis
Creators: name: Wojas, Adrianna
name: Scheidgen, Markus
Publisher: name: Zenodo
Year: 2023

description: The NOMAD poster provides a comprehensive overview of two powerful tools, NOMAD and NOMAD Oasis, designed to revolutionize the landscape of scientific data research. Developed by the FAIRmat consortium, NOMAD and NOMAD Oasis promote the principles of Findable, Accessible, Interoperable, and Reusable(FAIR) data, enhancing transparency and collaboration in materials science. NOMAD is a centralized material science data repository addressing the needs of researchers from various domains and fields. It seamlessly manages diverse data formats, including raw files, facilitating efficient data analysis and exploration. The posterhighlights the key features and use cases of NOMAD and NOMAD Oasis while thoroughly exploring their capabilities.The project outlines the data workflow within the NOMAD ecosystem, illustrating how uploaded data is transformed into processed and modeled data. Subsequently, it offers three options for utilizing the parsed data: publish, analyze, and explore. Researchers can leverage NOMAD's data publishing capabilities toshare their findings with the scientific community, obtain a DOI, and support open collaboration. By promoting FAIR data research, the NOMAD poster underscores the importance of data integrity, accessibility, and interoperability. It is a valuable resource for scientists, data centers, and scientific organizations, showcasingthe potential of NOMAD and NOMAD Oasis in everyday workflow.
description: This work is funded by the NFDI consortium FAIRmat - Deutsche Forschungsgemeinschaft (DFG) - Project 460197019
Electronic supplementary material from Historical citizen science to understand and predict climate-driven trout decline
Creators: name: Clavero, Miguel
name: Ninyerola, Miquel
name: Hermoso, Virgilio
name: Filipe, Ana Filipa
name: Pla, Magda
name: Villero, Daniel
name: Lluís Brotons
name: Delibes, Miguel
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Environmental Science
subject: Ecology
subject: FOS: Biological sciences

description: Figure S1. Annual average daily mean temperatures in Spain for the period 1850-2005. Represented values are anomalies (in °C) from the mean values from 1961 to 1990, as reported by Brunet et al. (2007). Squares and whiskers are mean and standard error values for the periods 1850-1870, 1900-1920 and 1990-2005. A and B mark the significant differences among periods found by a Tukey HSD post-hoc test (P< 0.001). The temporal temperature trend is represented by a weighted average line with a 10-year period Brunet M et al. 2007 Temporal and spatial temperature variability and change over Spain during 1850–2005. J. Geophys. Res. 112, D12117.; Figure S2. Response curves of thermic suitability for trout to temperature variables using data from 1850 and 2000. The values shown are average suitability for temperature categories of 0.5 °C intervals, using 2000 temperature as a reference. Annual mean, July maximum and January minimum have 32, 36 and 35 categories, respectively. The curves shown correspond to those modelling techniques that accurately predicted trout distribution in both periods (i.e., AUC > 0.7).GLM: Generalized Linear Models; GBM: Generalized Boosting Models; GAM: Generalized Additive Models; ANN: Artificial Neural Networks; FDA: Flexible Discriminant Analysis; MARS: Multivariate Adaptive Regression Splines; and RF: Random Forest. Classification Tree Analysis (CTA) and Surface Range Envelope (SRE) were also run but are not shown in the figure for not reaching AUC thresholds.; Figure S3. Extinction probability as determined by trout prevalence in 10×10km cells. Proportion of extinction cells (trout cited in the 1850s but not in the 2000s) among the different categories of trout prevalence defined for cells with information from at least 3 localities from the Madoz (1850s data). Low: trout present in 1 to 50% of the localities (n= 48); High: trout present in 51 to 90% of the localities (n= 178); Widespread: trout present in more than 90% of the localities (n= 439).; Figure S4. Changes in temperatures in Spain between the 1850s and 2000s climatic scenarios. See methods for a description of the development of climatic scenarios; Figure S5. Relationship between the predicted and observed changes in thermal suitability for trout between the 1850s and 2000s. Predicted change was calculated as the suitability difference between the projection of the 1850s model to the 2000s thermal scenario (2000s predictions) and the 1850s estimates, while observed change is the difference between the suitability estimates of the 2000s and the 1850s models.
Introducing an algorithm for the automatic detection of interface positions for flange joints based on laser triangulation measurements
Creators: name: Pordzik, Ronald
name: Mattulat, Thorsten
Publisher: name: BIAS Verlag
Year: 2022
Subjects: subject: Laser brazing
subject: Joint interface detection
subject: Track control
subject: 620

description: Laser brazing is a joining technique widely applied in industrial manufacturing such as automotive production. In order to establish a stable brazing process free of defects, it is necessary to support the process with a track control. Whereas conventional laser brazing processes rely on tactile track control based on the mechanical interaction between the brazing wire and the substrate surface, new approaches like the reflection-assisted laser brazing require vision-based detection of the joining interface for track control as the brazing wire is already molten when contacting the substrate surface. Especially in the case of brazing flange joints the visual detection of the interface position is challenging given the limited visual accessibility of the joint interface. Therefore, in order to reliably detect the interface position, a semi-analytic algorithm is introduced based on the signals from a laser triangulation sensor scanning the joint geometry ahead of the process zone. Hereby information about the joint geometry is used to extrapolate the surface contours of the joining partners into areas that are not visible to the sensor. The algorithm was successfully tested on 90° and 45° flange joints resulting in an uncertainty in the determination of the interface position of less than ±0.5 mm.
»Kein Thema!« – Eine korpuslinguistische Exploration
Creators: name: Callies, Marcus
Publisher: name: Universität Bremen
Year: 2023
Subjects: subject: Linguistik
subject: Thema
subject: Korpuslinguistik
subject: Pragmatik
subject: Diskursanalyse
subject: Sprachvergleich
subject: 410

description: Beitrag zum U Bremen Thementag »Wieviel Gesellschaft ist im Thema?«
Subjekt? – Kein Thema!
Creators: name: Stolz, Thomas
Publisher: name: Universität Bremen
Year: 2023
Subjects: subject: Linguistik
subject: Thema
subject: Systemlinguistik
subject: Topik-Kommentar-Struktur
subject: Subjektdefinition
subject: 410

description: Beitrag zum U Bremen Thementag »Wieviel Gesellschaft ist im Thema?«
Zur diskurskritischen Konstruktion des Begriffs des Themas
Creators: name: Kumięga, Łukasz
Publisher: name: andere Institution
Year: 2023
Subjects: subject: Linguistik
subject: Thema
subject: Gegenstand
subject: Diskurs
subject: Gouvernementalität
subject: 410

description: Beitrag zum U Bremen Thementag »Wieviel Gesellschaft ist im Thema?«
#Bibi – und alle wissen, dass es um Trennung geht – Überlegungen zur Rolle von Hashtags bei der Themenentfaltung in Sozialen Medien
Creators: name: Marx, Konstanze
Publisher: name: andere Institution
Year: 2023
Subjects: subject: Linguistik
subject: Thema
subject: Hashtag
subject: Kontext
subject: Twitter
subject: 410

description: Beitrag zum U Bremen Thementag »Wieviel Gesellschaft ist im Thema?«
Supplementary document from Why do students quit school? Implications from a dynamical modelling study
Creators: name: Amdouni, Bechir
name: Marlio Paredes
name: Kribs, Christopher
name: Anuj Mubayi
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 10299 Applied Mathematics not elsewhere classified
subject: FOS: Mathematics
subject: 19999 Mathematical Sciences not elsewhere classified

description: In 2012, more than three million students dropped out from high school. At this pace, we will have more than 30 million Americans without a high school degree by 2022 and relatively high dropout rates among Hispanic and African American students. We have developed and analysed a data-driven mathematical model that includes multiple interacting mechanisms and estimates of parameters using data from a specifically designed survey applied to a certain group of students of a high school in Chicago to understand dynamics of dropouts. Our analysis suggests students' academic achievement is directly related to the level of parental involvement more than any other factors in our study. However, if the negative peer influence (leading to lower academic grades) increases beyond a critical value, the effect of parental involvement on the dynamics of dropouts becomes negligible.
Thema talken – ein Editorial
Creators: name: Engelken, Julian
name: Glund, Marc
name: Hensellek, Jan
name: Herford, Lara
name: Langrock, Saskia
name: Poghosyan, Sargis
name: Schmalwieser, Susanne S.
name: Warnke, Ingo H.
Publisher: name: Universität Bremen
Year: 2023
Subjects: subject: Linguistik
subject: Thema
subject: 410

description: Beitrag zum U Bremen Thementag »Wieviel Gesellschaft ist im Thema?«
title: "Quattro colonne con decorazione a festoni e bucrani", Valadier Luigi, invv. CCVa-CCXIIIa-CCLVIIa-CCLXIVa (ITA/EN)
title: Scheda catalogo digitale Borghese
titleType: AlternativeTitle
Creators: name: Felici, Sonja
name: Galleria Borghese
Publisher: name: Galleria Borghese
Year: 2025

description: Pubblicazione delle schede delle opere conservate nel museo ed estratte dal catalogo digitale di Galleria Borghese, nelle due versioni esistenti online, in italiano e inglese.

Collegamento al catalogo digitale:

ITA: https://www.collezionegalleriaborghese.it/

EN: https://www.collezionegalleriaborghese.it/en
Quantum state visualization, verification and validation via phase space methods
Creators: name: Rundle, Russell
Publisher: name: Loughborough University
Year: 2020
Subjects: subject: 91399 Mechanical Engineering not elsewhere classified
subject: FOS: Mechanical engineering

description: Since its introduction in the 1930s by Wigner, and its generalisations by Moyal and Weyl, the ability to associate an operator on Hilbert space by a quasi-probability distribution function on phase space has found extensive use in the physics of con- tinuous variable systems. Lacking, however, is finite system applications; to date, such functions have taken a back seat to state vector, path integration, and Heisen- berg representations.In recent work, this lack of application has been addressed by giving a general framework to generate phase-space distribution functions for any system. Where the Wigner function for any system can be expressed in displaced parity form. This construction of a general framework for treating quantum mechanics in phase space will be presented in full in this thesis. Demonstrating a general approach to quantum mechanics as a statistical theory.Using this work, it will be shown how varied quantum systems can be easily represented in phase space as well as visualise certain quantum properties, such as entanglement, within these systems. In particular, formalism is applied to directly measure phase space coordinates of multiple qubit states, including a five-qubit GHZ state, on IBM’s Quantum Experience. Further, how these methods can be extended for use in general composite quantum systems, such as hybrid atom-cavity systems, will be presented, demonstrating how these phase-space methods are an optimal method for quantum state analysis, entanglement testing, and state characterisations.
Clinical features of patients with IgG4-related disease complicated with perivascular lesions
Creators: name: Ebe, Hiroshi
name: Tsuboi, Hiroto
name: Hagiya, Chihiro
name: Takahashi, Hiroyuki
name: Yokosawa, Masahiro
name: Hagiwara, Shinya
name: Hirota, Tomoya
name: Kurashima, Yuko
name: Chinatsu Takai
name: Miki, Haruka
name: Asashima, Hiromitsu
name: Umeda, Naoto
name: Kondo, Yuya
name: Ogishima, Hiroshi
name: Suzuki, Takeshi
name: Chino, Yusuke
name: Matsumoto, Isao
name: Sumida, Takayuki
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: Objective. To define the clinical features of IgG4-related disease (IgG4-RD) complicated with perivascular lesions. Methods. The clinical features of seven patients with IgG4-RD and perivascular lesions diagnosed at the University of Tsukuba Hospital between October 2008 and October 2013, were analyzed, including clinical background, results of imaging studies, satisfaction of the 2011 comprehensive diagnostic criteria (CDC) for IgG4-RD, laboratory data, distribution of perivascular lesions, involvement of other organs, and response to steroid therapy. Results. We studied six men and one woman with a mean age of 66.9 ± 6.7 years (± SD). Six of seven patients were diagnosed as definite IgG4-RD, while the seventh was considered possible IgG4-RD, based on the CDC for IgG4-RD. Serum IgG4 levels at diagnosis were higher than 135 mg/dl in all seven patients (mean, 933 ± 527). Serum C-reactive protein (CRP) levels were elevated in two only (mean, 1.42 ± 3.56 mg/dl). The perivascular lesions were located in the pulmonary artery (n = 1), thoracic aorta (n = 2), abdominal aorta (n = 6), coronary (n = 1), celiac (n = 1), superior mesenteric (n = 1), renal (n = 2), inferior mesenteric (n = 5), and iliac (n = 3) arteries. In addition to perivascular lesions, six patients showed involvement of other organs. All seven patients were treated with prednisolone (0.6 mg/kg/day), which rapidly improved the perivascular and other organ lesions in six patients (the other one patient have not yet been evaluated due to the short follow-up). Conclusion. Perivascular lesions show wide distribution in patients with IgG4-RD. Serum CRP levels are not necessarily elevated in these patients. Steroid therapy is effective in IgG4-RD and results in resolution of lesions.
Early response to certolizumab pegol predicts long-term outcomes in patients with active rheumatoid arthritis: results from the Japanese studies
Creators: name: Takeuchi, Tsutomu
name: Yamamoto, Kazuhiko
name: Yamanaka, Hisashi
name: Ishiguro, Naoki
name: Tanaka, Yoshiya
name: Eguchi, Katsumi
name: Watanabe, Akira
name: Origasa, Hideki
name: Shoji, Toshiharu
name: Miyasaka, Nobuyuki
name: Koike, Takao
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Plant Biology

description: Objectives. A post-hoc analysis was performed to determine the relationship between the timing and magnitude of DAS28(ESR) response and long term outcomes in Japanese patients after 1 year of CZP treatment. Methods. Our analysis included 82 J-RAPID trial patients treated with CZP 200 mg and methotrexate, and 116 HIKARI trial patients treated with CZP 200 mg alone or with disease-modifying agents other than methotrexate. Remission rates and changes in mTSS at year 1 were compared to the DAS28(ESR) response at week 12 of CZP treatment. Results. After 1 year of treatment, remission was achieved in 41.3% of the J-RAPID and 34.9% of the HIKARI patients with a week 12 DAS28(ESR) response of ≥ 1.2. In comparison, patients with a DAS28(ESR) response of < 1.2 at week 12 only had a < 7% probability of achieving remission and displayed higher change in mTSS after 1-year treatment. Conclusions. The likelihood of remission and extent of radiographic progression after 1 year was associated with the week 12 DAS28(ESR) response. The DAS28(ESR) response at 12 weeks could be beneficial for identifying patients that are unlikely to respond to prolonged CZP treatment.
title: Αστικές και τοπιακές συζεύξεις στο λανθάνον βιομηχανικό «κατώφλι» του Περισσού | Η  ενσωμάτωση της βιομηχανίας της Columbia στον αστικό ιστό
title: Urban and landscape connections in the latent industrial "threshold" of Perissos | The incorporation of Columbia industry into the urban fabric
Creators: name: Κωστακη Μαρινα
name: Σμυρναιου Ευσταθια
Publisher: name: Technical University of Crete
Year: 2022

description: Η περιοχή τοποθετείται στο μεταίχμιο του ρέματος της Φιλαδέλφειας και των σιδηροδρομικών γραμμών του Περισσού. Συντελεί ένα βιομηχανικό κατώφλι, ένα ενδιάμεσο που επιδιώκει να σταθεί πλάι στα υφιστάμενα  κελύφη της γειτονιάς και στην μικροκλίμακα των προσφυγικών. Το ρέμα και το άλσος συμπαρασύρουν εναν πιο άναρχο κι οργανικό ιστό, ενώ οι γραμμές του ηλεκτρικού ορίζουν ένα πιο οργανωμένο και αυστηρό κάναβο. Μεταξύ τους, οι έντονες υψομετρικές διαφορές δημιουργούν μια αυλάκωση στο τοπίο, εντείνοντας τα εκατέρωθεν όρια. Η υφιστάμενη βύθιση του εδάφους καθιστά απαραίτητη τη συνομιλία και την πλέξη των ετερογενών καταστάσεων. Παρατηρούνται έντονες εναλλαγές στην κοκκομετρία της περιοχής ως προς την πυκνότητα αλλά και την διαφοροποίηση στις κλίμακες των κελυφών(βιομηχανικά-προσφυγικά). Η σύνθεση επιδιώκει την πλέξη του τοπίου με το δομημένο και την δημιουργία πολιτιστικού ιστού που ενσωματώνει το κέλυφος της Columbia.
Erwimp project bioinformatic code update March 2024
Creators: name: Pilgrim, Jack
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 310204
subject: Genomics and transcriptomics

description: These files describe the code for quality control, assembly, and comparative genomic analysis of an Erwinia associated with the Highland Midge (Culicoides impunctatus)
Genetic variants of DNMT3A and systemic lupus erythematosus susceptibility
Creators: name: Piotrowski, Piotr
name: Malwina K. Grobelna
name: Wudarski, Mariusz
name: Olesińska, Marzena
name: Paweł P. Jagodziński
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified

description: Objectives. A significant increase in DNA methyltransferase 3A (DNMT3A) transcript levels has recently been demonstrated in peripheral blood mononuclear cells from systemic lupus erythematosus (SLE) patients as compared to healthy individuals. Methods. Employing high resolution melting curve analysis (HRM) and PCR-restriction fragment length polymorphism analysis, we assessed the frequency of five single nucleotide polymorphisms (SNPs) of this gene: rs2289195, rs7590760, rs13401241, rs749131 and rs1550117, situated in different linkage disequilibrium blocks of the DNMT3A gene in two hundred and fifty seven women with SLE and six hundred and twenty five controls. Results. The lowest p values of the trend test were observed for the DNMT3A -448A> G (rs1550117) SNP (ptrend = 0.0111). We also found that, in a dominant inheritance model, the DNMT3A -448A> G SNP may protect from SLE development [odds ratio (OR) = 0.494 (0.294–0.830), p = 0.0068, pcorr = 0.034]. Furthermore, we observed that the DNMT3A -448A > G SNP in dominant inheritance models may protect from immunologic manifestations of SLE [OR = 0.1753 (95% CI = 0.04976–0.6176, p = 0.0026, pcorr = 0.0468). Conclusions. Our study demonstrates that the DNMT3A -448A> G SNP might protect from SLE and its immunologic manifestations in a sample from the Polish population.
Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers.
Creators: name: Iyer, R Sumanth
name: Needham, Sarah R
name: Galdadas, Ioannis
name: Davis, Benjamin M
name: Roberts, Selene K
name: Man, Rico CH
name: Zanetti-Domingues, Laura C
name: Clarke, David T
name: Fruhwirth, Gilbert O
name: Parker, Peter J
name: Rolfe, Daniel J
name: Gervasio, Francesco L
name: Martin-Fernandez, Marisa L
Publisher: name: The Francis Crick Institute
Year: 2024
Subjects: classificationCode: Signalling & Oncogenes
subject: Signalling & Oncogenes
classificationCode: Chemical Biology & High Throughput
subject: Chemical Biology & High Throughput
classificationCode: Biochemistry & Proteomics
subject: Biochemistry & Proteomics
classificationCode: Cell Biology
subject: Cell Biology
classificationCode: Cell Cycle & Chromosomes
subject: Cell Cycle & Chromosomes

description: The Epidermal Growth Factor Receptor (EGFR) is frequently found to be mutated in non-small cell lung cancer. Oncogenic EGFR has been successfully targeted by tyrosine kinase inhibitors, but acquired drug resistance eventually overcomes the efficacy of these treatments. Attempts to surmount this therapeutic challenge are hindered by a poor understanding of how and why cancer mutations specifically amplify ligand-independent EGFR auto-phosphorylation signals to enhance cell survival and how this amplification is related to ligand-dependent cell proliferation. Here we show that drug-resistant EGFR mutations manipulate the assembly of ligand-free, kinase-active oligomers to promote and stabilize the assembly of oligomer-obligate active dimer sub-units and circumvent the need for ligand binding. We reveal the structure and assembly mechanisms of these ligand-free, kinase-active oligomers, uncovering oncogenic functions for hitherto orphan transmembrane and kinase interfaces, and for the ectodomain tethered conformation of EGFR. Importantly, we find that the active dimer sub-units within ligand-free oligomers are the high affinity binding sites competent to bind physiological ligand concentrations and thus drive tumor growth, revealing a link with tumor proliferation. Our findings provide a framework for future drug discovery directed at tackling oncogenic EGFR mutations by disabling oligomer-assembling interactions.
Obstacles to the implementation of the treat-to-target strategy for rheumatoid arthritis in clinical practice in Japan
Creators: name: Kaneko, Yuko
name: Koike, Takao
name: Oda, Hiromi
name: Yamamoto, Kazuhiko
name: Miyasaka, Nobuyuki
name: Harigai, Masayoshi
name: Yamanaka, Hisashi
name: Ishiguro, Naoki
name: Tanaka, Yoshiya
name: Takeuchi, Tsutomu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy

description: Objective. To clarify the obstacles preventing the implementation of the treat-to-target (T2T) strategy for rheumatoid arthritis (RA) in clinical practice. Methods. A total of 301 rheumatologists in Japan completed a questionnaire. In the first section, participants were indirectly questioned on the implementation of basic components of T2T, and in the second section, participants were directly questioned on their level of agreement and application. Results. Although nearly all participants set treatment targets for the majority of RA patients with moderate to high disease activity, the proportion who set clinical remission as their target was 59%, with only 45% of these using composite measures. The proportion of participants who monitored X-rays and Health Assessment Questionnaires for all their patients was 44% and 14%, respectively. The proportion of participants who did not discuss treatment strategies was 44%, with approximately half of these reasoning that this was due to a proportion of patients having a lack of understanding of the treatment strategy or inability to make decisions. When participants were directly questioned, there was a high level of agreement with the T2T recommendations. Conclusion. Although there was a high level of agreement with the T2T recommendations, major obstacles preventing its full implementation still remain.
High resolution pdf files of DiapixUK picture materials - original English version
Creators: name: Hazan, Valerie
name: Baker, Rachel
Publisher: name: Zenodo
Year: 2011
Subjects: speech elicitation
spontaneous speech
problem-solving task

description: This zipped folder contains high-resolution pdf versions of the DiapixUK picture materials, described in Baker and Hazan (2011) (https://doi.org/10.3758/s13428-011-0075-y). There are 12 picture pairs: 4 'beach' scenes, 4 'farm' scenes and 4 'street' scenes, as well as a single 'park' scene, typically used for initial training. The folder also contains a metadata file and a copy of Baker and Hazan (2011) which describes the design and piloting of the picture materials. The photoshop versions of these materials are provided in a separate zipped folder. These can be used to make adaptations to the pictures, e.g. for use with participants from different language backgrounds.
description: {"references": ["Baker, R., and Hazan, V. (2011). DiapixUK: Task materials for the elicitation of multiple spontaneous speech dialogs. Behavior Research Methods Instrumentation 43, 761\u2013770. https://doi.org/10.3758/s13428-011-0075-y"]}