cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Regulation of early ecdysone-inducible genes in Drosophila
Creators: name: Karim, Felix Darius
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Muntants

description: n the fruit fly Drosophila melanogaster, a pulse of the steroid hormone ecdysone triggers metamorphosis. Ecdysone activates a genetic regulatory hierarchy that can be visualized as a reproducible pattern of puffs in the polytene chromosomes of the larval salivary gland. A model for ecdysone-regulated puffing suggests that the so-called early puffs (genes) are directly induced by ecdysone and that the protein products of these early genes induced a large set of the late puffs (genes) as a secondary response to the hormone. An early ecdysone-inducible gene, E74, was cloned and characterized. This gene contains two transcription units, E74A and E74B. The two E74 transcripts produce related DNA-binding proteins that bind to similar sequences via a common DNA-binding domain. This common DNA-binding domain, the ETS domain, consists of a stretch of $/sim$85 amino acids that is similar to the ets-1 oncoprotein and directs binding to similar DNA sequences. In addition, Northern blot analysis of RNA isolated from staged animals and cultured larval organs was used to study the transcriptional regulation of E74A and E74B as well as the early ecdysone-inducible transcripts of E75 (E75A, E75B and E75C), the BR-C and EcR. From this, the pattern of early promoter activity was defined in terms of two distinct responses to ecdysone. The class I early transcripts (E74B and EcR) are induced by lower ecdysone concentrations and repressed at higher concentrations. In contrast, the class II early transcripts (E74A, E75A and E75B) are induced by higher ecdysone concentrations. Hence, class I transcripts are induced early in third instar larvae and mid-prepupae with the leading edges of the ecdysone pulses and repressed with the subsequent peaks in hormone titer, as the class II RNAs are induced. The BR-C transcripts appear to have both class I and class II characteristics. Molecular analysis of BR-C mutants demonstrated that the npr1 and 2Bc, but not the br and rbp, functions are required for complete ecdysone-induction of E74A and E75A transcription. Based on these studies, a modified model for the ecdysone regulatory hierarchy was proposed.
Energy efficiency optimization of cooperative communication in IEEE 802 15.5 ir uwb wban
Creators: name: ARAVIND M T
Publisher: name: figshare
Year: 2020
Subjects: subject: 90699 Electrical and Electronic Engineering not elsewhere classified
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: This paper presents an exhaustive study on the use of one-relay and two-relay cooperative communication schemes and 2-hop communication scheme for improving the energy efficiency and reliability of ultra-wideband based wireless body area networks (UWB WBANs). Various investigations have been performed to study the impact of the parameters like packet size, hop distance, transmit power and channel error rate on the energy efficiency and reliability. An optimal packet size is obtained for the maximization of energy efficiency for both on-body communication and in-body communication. The analytical and simulation results show enhanced reliability with cooperative communication than direct communication and 2-hop communication, for all values of source to destination distances. The results also depict a threshold behaviour for energy efficiency which separates the hoplength for direct transmission from the hoplength where cooperation and 2-hop communication will be useful. The simulation results reveal that if the channel conditions are poor, when the source to destination distance is larger than the threshold value, 2-hop communication gives higher energy efficiency compared with direct and cooperative communications
Speech act theory and internet culture: computer-mediated communication in the era of Web 2.0
Creators: name: Sovinsky, Stephen John
Publisher: name: University of Utah
Year: 2012
Subjects: Speech acts (Linguistics)
Internet Social aspects
Communication and technology

description: In this thesis I argue for Speech Act Theory's continued relevance today. Particularly in the context of the Web 2.0 movement and Computer-Mediated Communication (CMC), J. L. Austin's basic notions of performatives, illocutionary and perloctionary acts, and infelicity seem to offer vast insight into what is going on with social interaction on the Internet. In the era of Wikipedia, YouTube, MySpace, Facebook, and Twitter we see the use of language developing and changing to fit the need of users online. In an increasingly social online world, it is no surprise then that the majority of interaction is facilitated via speech acts. Commenting and posting online, for instance, clearly lie in the realm of speech acts, with the act of posting being the locutionary act, and the effect on the world the perlocution, etc. I look at a number of phenomena including: speech in online computer games, 'gestures' in chat groups, emoticons, and Internet abbreviations. How we are using language online offers great insights in how language conveys meaning.
Study on preparation, characterization and multidrug resistance reversal of red blood cell membrane-camouflaged tetrandrine-loaded PLGA nanoparticles
Creators: name: Que, Xiao
name: Su, Jing
name: Guo, Pengcheng
name: Kamal, Zul
name: Xu, Enge
name: Liu, Siyu
name: Chen, Jieyu
name: Qiu, Mingfeng
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Hematology

description: The multidrug resistance in tumor (MDR) is a major barrier to efficient cancer therapy. Modern pharmacological studies have proven that tetrandrine (TET) has great potential in reversing MDR. However, it has a series of medication problems in clinic such as poor water solubility, low oral bioavailability and short half-life in vivo. Aiming at the above problems, red blood cell membrane-camouflaged TET-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (RPTNs) had been developed. The RPTNs had spherical shell-core double layer structure with average particle size of 164.1 ± 1.65 nm and encapsulation efficiency of 84.1% ± 0.41%. Compared with TET-PLGA nanoparticles (PTNs), the RPTNs reduced RAW 264.7 macrophages’ swallowing by 32% due to its retention of natural membrane proteins. The cumulative drug release of RPTNs was 81.88% within 120 h. And pharmacokinetic study showed that the blood half-life of RPTNs was 19.38 h, which was 2.95 times of free drug. When RPTNs of 2 μg/mL TET were administered in combination with adriamycin (ADR), significant MDR reversal effect was observed in drug-resistant cells MCF-7/ADR. In a word, the RPTNs hold potential to improve its efficacy and broaden its clinical application.
Simplifying the creation and deployment of collaborative data analysis and visualization tools
Creators: name: Dos Santos, Marques Emanuele
Publisher: name: University of Utah
Year: 2012
Subjects: Data analysis
Provenance
Visualization systems
Workflow systems

description: Managing and understanding the large amounts of scientific data is undoubtedly one of the most difficult research challenges scientists are facing today. Data exploration through visualization is an effective means to understand and obtain insights from large collections of data. Although several visualization tools are available, including tools with sophisticated visual interfaces, they are out of reach for users who have little or no knowledge of visualization techniques and/or who do not have programming expertise. In addition, as interdisciplinary groups work together, the ability to generate a diversified collection of analyses for a broad audience in an ad-hoc manner is essential for supporting effective scientific data exploration. Science portals and visualization web sites have been used to simplify this task by aggregating data from different sources and by providing a set of predesigned analyses and visualizations. However, such portals are often built manually, and are not flexible enough to support the vast heterogeneity of data sources, analysis  techniques, data products, and user communities that need to access this data. The goal of this dissertation is to provide a complete framework for streamlining the  creation of customized visualization applications and to facilitate collaboration and sharing among scientists and visualization experts. The framework is composed of three main components: VisMashup, for creating customized visualization applications based on dataflow  specifications; Provenance-Rich Publications, a component that allows users to create documents  (web pages, presentations or pdf files) whose digital artifacts (e.g.,figures) include detailed provenance information (workflow and associated parameters) used to produce the artifact; and CrowdLabs, a system that adopts the model used by social Web sites and that combines a set of usable tools and a scalable infrastructure for providing a rich collaborative environment for scientists and that also takes into account the requirements of computational scientists, such as accessing high-performance computers and manipulating large amounts of data. To demonstrate how users can benefit from this framework, a series of use case scenarios is also included.
Evaluation of a Tailored Website to Support Interpretation of Genetic Test Results for Lynch Syndrome
Creators: name: Satyala, Mrudula
Publisher: name: University of Utah
Year: 2014

description: Patients find genetic test results hard to interpret. Information about testing colon cancer (CRC) patients for Lynch syndrome (LS) is particularly complex as it involves several laboratory tests and has to be interpreted along with family/ personal health history information. In this study, the example of LS was used to explore methods of presenting information to patients. Specifically, the tailoring of information was compared to the general didactic presentation in a web-based format for communicating genetic test results to patients. Ninety volunteers, aged 50-75, with ability to read and write English and familiarity with using the Internet were recruited from the Osher Lifelong Learning Institute at The University of Utah and through ResearchMatch.org. Healthcare professionals/ students, people with a professional medical background and the University faculty were excluded. This study was a postintervention, two-group randomized controlled trial. For evaluating the website, a vignette of a typical CRC patient being tested for LS was designed and participants were asked to imagine that they were the patient described in the scenario. They were then asked to interpret the test reports and answer a survey. The primary outcome was genetic knowledge based on interpretation of the test results. The other outcomes were task completion (correct/ incorrect), time to complete the task, usability and usefulness of the website. iv The two groups showed no statistically significant difference in total knowledge score, task completion and usefulness outcomes. Inconsistent differences were found between groups for individual knowledge questions. Time data had to be excluded from our analysis as there were inconsistencies in reporting time. Usability was rated significantly higher for the nontailored website. Our study has demonstrated that online tailored communication of genetic test results is possible and effective, although it could not determine conclusively if tailoring is more effective than nontailoring methods for conveying complex genetics-based testing information to patients. Future research on evaluating the website for its usability through cognitive response methods with actual CRC patients is necessary to get more insights into how the users actually process information and clarify these results.
Sonnenfleckenzeichnung Nr. 23401.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 13.07.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Engagement of adult undergraduates: insights from the National Survey of Student Engagement
Creators: name: Southerland, J. Nathaniel
Publisher: name: University of Utah
Year: 2012
Subjects: Adult
Engagement
Persistence
Retention
Student
Undergraduate

description: Adults are participating in all levels of higher education in increasing numbers due to a variety of societal, cultural, technological, and economic pressures. While many  adult students attend 2-year colleges and technical institutions, 4-year colleges and universities are also enrolling substantial percentages of adult students. Nevertheless, adult college students - those who are functionally independent, have substantial work/life experience, and must balance school demands with extra-institutional obligations - experience low persistence and graduation rates comparative to their  nonadult peers at these institutions. The literature on student retention points to the importance of academic integration for adult students. In recent years, student  engagement - or participation in a variety of effective educational practices linked to successful outcomes - has been presented as an alternative formulation of academic integration. Prior research points to the importance of student engagement as a critical  influence on student retention. The National Survey of Student Engagement [NSSE] measures engagement on five different benchmarks whose relevance for adult students is verified by the adult learning theory literature. This study utilizes data from the 2005  NSSE and correlational research methods to create an operationally useful definition of adult students and to compare their engagement on each of the five benchmarks to that of their nonadult peers. The findings are then explored to suggest refinements to current  theory and practice and directions for future research regarding adult students.
New techniques for microscale structural studies by mass spectrometry
Creators: name: Hsu, Fong Fu
Publisher: name: University of Utah
Year: 2012
Subjects: Chromatography, Gas
Spectrum Analysis, Mass

description: A chiral GC/MS separation and identification of TFA derivatives of monosaccharides and methanolysis products of carbohydrates and glycoconjugates were developed using a Chirasil-Val column.  Both ? and ? anomers were formed in the preparation of TFA derivatives.  The ratio of ? anomers to ? anomers is characteristic for each monosaccharide which can provide additional information in compound identification.  The developed methods have been successfully used to the identification of sugar moieties in modified queuosine nucleosides and modified DNA isolated from the Rhizobium bacteriophage DNA.   A new HPLC separation method which is suitable for thermospray ionization was developed for the separation of mononucleotides.  Thermospray LC/MS was shown to be a powerful tool in the structural elucidation of nucleotides and nucleosides.  The major ions observed in the thermospray spectra of nucleotides were identified as MH+, NH2+, BH2+ and ions related to the sugar moieties, and their NH4+ cluster ions.  Hydrolysis and thermolysis may play a major role in the thermospray ionization of nucleotides and nucleosides, although the ammonia chemical ionization mechanism may also be important.  No spectrum difference has been observed for 5'-, 3'-, and 2'-mono-mucleotides; however, the studies of spectra cytidine 3',5'-cyclic monophosphate and cytidine 2',3'-cyclic monophosphate indicate that isomer differentiation by thermospray ionization may be possible.  Combined HPLC-thermospray mass spectrometry of mono- and disaccharides, 1-0-methylglycosides and 0-permethyl mono- through tetrasaccharides have been studies to assess the potential role of thermospray ionization for microscale structural studies of saccharides and glycoconjugates and for high sensitivity detection of liquid chromatographic effluents.  Using HCO2NH4 as eluant for reversed-phase HPLC, abundant MNH4+ ions are formed from monosaccharides and mono- and permethylated saccharides, and are suitable for monitoring subnanogram constituents in HPC effluents.  Detection of 100 pg 1-0methylhexopyranosides with signal/noise>10 is demonstrated.  Hydrolysis and thermolysis appear to be the predominant mechanisms in the thermospray ionization in intact mono-, di-, tri-, and tetrasaccharides; therefore consecutive losses of H20 and ions corresponding to hydrolysis products are the major fragment ions.  For permethylated carbohydrates, a mechanism analogous to ammonia CI may play the major role.  Positional isomers of methylmonosaccharides are chromatographically separable and spectroscopically distinguishable; which may imply the potential of thermospray LC/MS in the structural elucidation of carbohydrates and glycoconjugates at the microscale.
Evaluating the Effects of Noninteractive and Machine-Assisted Interactive Manual Clinical Text Annotation Approaches on the Quality of Reference Standards
Creators: name: South, Brett Ray
Publisher: name: University of Utah
Year: 2014

description: Manual annotation of clinical texts is often used as a method of generating reference standards that provide data for training and evaluation of Natural Language Processing (NLP) systems. Manually annotating clinical texts is time consuming, expensive, and requires considerable cognitive effort on the part of human reviewers. Furthermore, reference standards must be generated in ways that produce consistent and reliable data but must also be valid in order to adequately evaluate the performance of those systems. The amount of labeled data necessary varies depending on the level of analysis, the complexity of the clinical use case, and the methods that will be used to develop automated machine systems for information extraction and classification. Evaluating methods that potentially reduce cost, manual human workload, introduce task efficiencies, and reduce the amount of labeled data necessary to train NLP tools for specific clinical use cases are active areas of research inquiry in the clinical NLP domain. This dissertation integrates a mixed methods approach using methodologies from cognitive science and artificial intelligence with manual annotation of clinical texts. Aim 1 of this dissertation identifies factors that affect manual annotation of clinical texts. These factors are further explored by evaluating approaches that may introduce efficiencies into manual review tasks applied to two different NLP development areas - semantic annotation of clinical concepts and identification of information representing Protected Health Information (PHI) as defined by HIPAA. Both experiments integrate iv different priming mechanisms using noninteractive and machine-assisted methods. The main hypothesis for this research is that integrating pre-annotation or other machineassisted methods within manual annotation workflows will improve efficiency of manual annotation tasks without diminishing the quality of generated reference standards.
Nova Era no Diagnóstico da Discinesia Ciliar Primária
Creators: name: Constant, Carolina
name: Sousa, Rodrigo
name: Pinto, Andreia
name: Moura Nunes, J. F.
name: Sampaio, Pedro
name: Lopes, Susana Santos
name: Bandeira, Teresa
name: Pereira, Luísa
Publisher: name: Portuguese Journal of Pediatrics
Year: 2018

description: Introdução: A discinésia ciliar primária (DCP) é uma doença genética rara que determina alterações estruturais e/ou funcionais dos cílios, cujo diagnóstico foi alvo de padronização recente. O objectivo deste estudo foi descrever os resultados dum processo de diagnóstico centralizado aplicado a um grupo de crianças elegíveis. Métodos: Análise descritiva dos casos com diagnóstico de DCP efectuados num período de dois anos (07/2014-06/2016). Recolha retrospectiva de dados demográficos, clínicos e dos resultados dos testes de diagnóstico efectuados. Resultados: Foram diagnosticados dez doentes com idade mediana de 9,9 (3-16,5) anos, cinco rapazes. Os padrões clínicos mais frequentes foram o início precoce, com dificuldade respiratória neonatal (9), e doença respiratória supurativa alta [otite média crónica/recorrente (10)] e baixa [tosse produtiva crónica (8) e bronquiectasias (6)]. A medição do óxido nítrico nasal (nNO) foi normal em dois casos, reduzido, mas acima do valor de cut-off para DCP em dois doentes e muito reduzido, sugestivo de DCP, nos restantes seis. A avaliação da ultraestrutura ciliar por microscopia eletrónica de transmissão (MET) identificou alterações em sete doentes e três foram inconclusivos. A análise do padrão e frequência do batimento ciliar por videomicroscopia de alta velocidade (VMAV) detectou alterações compatíveis em sete doentes, e foi inconclusiva em três. O estudo genético encontra-se em curso. Discussão: Estes são os primeiros resultados duma série de crianças com o diagnóstico de DCP efectuado através dum processo estruturado, centralizado e interdisciplinar. Tal como sugerido em literatura recente a existência de exames inconclusivos ou normais foi avaliada pela interpretação conjunta dos resultados.
description: Portuguese Journal of Pediatrics, Vol. 49 No. 3 (2018)
Rastreio Neonatal de Hemoglobinopatias: A Experiência de um Hospital de Nível II na Área Metropolitana de Lisboa
Creators: name: Teixeira, Ana Teresa
name: Garcia, Catarina
name: Ferreira, Teresa
name: Dias, Alexandra
name: Trindade, Cristina
name: Barroso, Rosalina
Publisher: name: Portuguese Journal of Pediatrics
Year: 2018

description: Introdução: As Hemoglobinopatias são doenças genéticas, causadas por alterações da produção de hemoglobina, das quais se destacam a doença falciforme e os síndromes talassémicos. O diagnóstico precoce das hemoglobinopatias é essencial: permite a implementação de medidas que reduzem a morbilidade e a mortalidade nestes doentes (como a profilaxia antibiótica, a imunização alargada e a educação parental). Objetivos: Caracterizar a população de recém-nascidos (RN) incluídos num programa de rastreio de hemoglobinopatias no ano de 2013, num hospital de nível II, na área metropolitana de Lisboa. Material e métodos: Estudo retrospetivo descritivo, dados colhidos nos registos clínicos e laboratoriais hospitalares, das crianças nascidas entre 1 de Janeiro e 31 de Dezembro de 2013, com origem familiar nas áreas de risco indicadas na Norma da Direção geral de Saúde (DGS) 18/DSMIA ou com história familiar de hemoglobinopatia. Aos RN incluídos foi realizado hemograma e eletroforese de hemoglobinas entre o primeiro e o terceiro dia de vida. Resultados: Realizados 739 rastreios (27,7% do total de crianças nascidas neste período). Foram detetadas 86 (12%) variantes do padrão normal de hemoglobinas, incluindo três casos de doença falciforme (dois casos de hemoglobinopatia SS e um caso de hemoglobinopatia SC) e 83 casos de portadores de hemoglobinopatias. Todos os RN com variantes de hemoglobina foram observados em consulta de Hematologia Pediátrica. Conclusões: Este rastreio permitiu a deteção precoce de novos casos de doença falciforme, com consequente melhoria dos cuidados prestados a estes doentes, e a deteção de portadores, possibilitando o aconselhamento às famílias.
description: Portuguese Journal of Pediatrics, Vol. 49 No. 3 (2018)
Building an AI-Powered Assistant for Computational Scientists
Creators: name: Vallabhajosyula, Swathi
name: Carstens, Bryan
name: Chen, Jian
name: Ramnath, Rajiv
name: Wolf, Matthew
Publisher: name: Zenodo
Year: 2022

description: The availability of high-performance computing (HPC) cyberinfrastructures (CI) like Ohio Supercomputer (OSC)[1] or Titan[2] enables scientists to perform computationally intensive experiments (reaching Exascale levels). These resources are expensive and hard to optimize, being shared between simple/complex tasks – long/short run times and billed per hour based on processing and memory requirements. We studied how AI injected into existing CIs could provide resource recommendations from application and system configurations, prior workflows and resulting interactions (CI traces, logs). This work examines: To what extent models trained on scaled-down datasets on commodity environments adapt to production environments, To what extent models built for specific applications can generalize to other applications within a family, and How the most appropriate model may change based on the type of data and its mix. We also describe and show the use of an automatable pipeline for generating the necessary training data and building the model.
Convective and rainfall properties of tropical cyclone inner cores and rainbands in relation to tropical cyclone intensity changes using eleven years of Tropical Rainfall Measuring Mission data
Creators: name: Ramirez, Ellen Michelle
Publisher: name: University of Utah
Year: 2012
Subjects: Hurricanes
TRMM
Tropical cyclones
Rainfall properties
Inner cores
Rainbands
Intensity changes
Satellite meteorology
Tropical Rainfall Measuring Mission

description: Covering December 1997 through December 2008, over 13,000 tropical cyclone (TC) overpasses of 945 TCs by the Tropical Rainfall Measuring Mission (TRMM)  satellite are used to document the observed passive microwave ice scattering magnitudes, radar reflectivity, IR cloud top height, total lightning, and derived rainfall parameters including rain rate, raining area, and volumetric rain. A semimanual method is used to divide TC raining area into inner core (IC), inner rainband (IB), and outer rainband (OB) regions. Precipitation features (PFs) within these regions are compared for their convective vigor and rainfall characteristics based on passive microwave, IR, radar, and lightning properties. These properties in the IC region are further examined in terms of different TC intensity and intensity change categories. TC intensity categories include tropical depressions (TDs), tropical storms (TSs), category 1-2 hurricanes (CAT12s), and category 3-5 hurricanes (CAT35s). The 24-h TC intensity change categories include weakening (W), neutral (N), slowly intensifying (SI), and rapidly intensifying (RI).  The stronger tails of the convective intensity distributions are found to be similar for features in both the IC and OB regions, while the features in the IB region yield the  weakest convective signatures. However, at the middle to weaker end of the convective spectrum, ice scattering signatures and reflectivity profiles are the strongest for features in the IC region, followed by those in the IB, then those in the OB. The same order is found for the whole distribution spectrum of feature conditional mean rain rates in these regions. The convective intensity of features in the IC region are found to increase as  storm intensity increases, except at the strongest end of the spectrum, where ice scattering signatures and reflectivity profiles are stronger in features associated with TS and TD strength storms rather than those associated with hurricane strength storms. The IC  conditional mean rain rate and volumetric rain increase as storm intensity increases. It is found that necessary conditions for RI are that the minimum 85 GHz PCT in the IC region must be less than 256 K and the minimum 37 GHz PCT must be less than 275 K. Over 98% of RI minimum 11?m brightness temperatures in the IC region are less than 212 K. RI storms always have larger raining area and volumetric rain in the IC region than storms in other intensity change categories.
Development of a hybrid piston cylinder cell for quasielastic neutron scattering experiments up to 1 GPa
Creators: name: Hattori, T.
name: Ohira-Kawamura, S.
name: Kawasaki, T.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: We have developed a hybrid piston cylinder cell for quasielastic neutron scattering (QENS) experiments up to about 1 GPa. It consists of a fretted cylinder made of the high tensile steel (SNCM439) liner and the Al alloy (NA700) jacket. Performance tests revealed that the cell can withstand a pressure of 0.8 GPa without irreversible damage and has 4.4 times larger neutron transmission at 3.14 meV (5.10 Å in wavelength) than that of a conventional CuBe monobloc cylinder. Combined with the sample assembly devised for suppressing multiple scattering, high quality QENS spectra of water were obtained up to 0.8 GPa. This study illustrates the efficacy of the hybrid cylinders not only for increasing maximum available pressure but also manipulating the available pressure and the signal intensity, depending on the purpose of the experiments.
Preparation and in vivo evaluation of a highly skin- and nail-permeable efinaconazole topical formulation for enhanced treatment of onychomycosis
Creators: name: Lee, Byung Chul
name: Pangeni, Rudra
name: Na, Jungtae
name: Koo, Kyo-Tan
name: Park, Jin Woo
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer

description: Onychomycosis is a progressive fungal infection of the nails that involves the deeper nail layer and nail bed. It is important to maintain sufficient drug concentration in the diseased tissues after topical application. In this study, a stable topical delivery system for efinaconazole (EFN) was designed to enhance absorption potential through the skin and nail plate by incorporating ethanol, diethylene glycol monoethyl ether (Transcutol P) and isopropyl myristate, and cyclomethicone into the topical solution as a delivery vehicle, permeation enhancers, and a wetting agent, respectively. In addition, the stability of EFN in the formulation was significantly improved by adding butylated hydroxytoluene, diethylenetriamine pentaacetic acid, and citric acid as an antioxidant, chelating agent, and pH-adjusting agent, respectively, without discoloration. The optimum EFN formulation (EFN-K) showed 1.46-fold greater human skin permeation than that of the reference control (commercial 10% EFN topical solution). Furthermore, after a 24-hour incubation, the amount of infiltrated EFN from EFN-K in the human nail plate was 4.11-fold greater than that of the reference control, resulting in an 89.7% increase in nail flux at 7 days after treatment. EFN-K significantly accelerated structural recovery of the keratin layer in a Trichophyton mentagrophytes-infected guinea pig onychomycosis model, decreasing the mean viable fungal cell count by 54.3% compared to the vehicle-treated group after once-daily treatment for 4 weeks. Thus, the accelerated skin and nail penetration effect of EFN-K is expected to achieve good patient compliance, and improve the complete cure rate of onychomycosis.
Sonnenfleckenzeichnung Nr. 23419.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 02.08.1970, erstellt von Antoine Zelenka
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung Nr. 23517.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 26.11.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Nurse practitioners' adherence to protocols
Creators: name: LaScala, Susan
Publisher: name: University of Utah
Year: 2012
Subjects: Primary Care
Nursing Research

description: In June 1980 the Nurse Practitioner Pilot Project was initiated by the Nurse Practitioner Conference Group of Utah. Sixty-two of Utah's 192 registered nurse practitioners became participants in the Pilot Project. Senate Bill 198 allowed nurse practitioners in the state of Utah to prescribe medications while practicing according to protocols in collaboration with approved physicians over a two and one-half year period.  The purpose of the research was to establish whether or not nurse practitioners adhered to protocols mandated by the law.  An ex-post facto chart review of the nurse practitioner participants was done according to recorded subjective, objective, laboratory and care plan information. Data revealed that 9 7% of the sample was practicing at a level higher than the minimum requirements of the protocol guidelines.  Demographic variables were not statistically significant in their relationship to nurse practitioners' adherence to protocols.
Sonnenfleckenzeichnung Nr. 23451.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 08.09.1970, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Novel ophthalmic formulation of myriocin: implications in retinitis pigmentosa
Creators: name: Platania, Chiara Bianca Maria
name: Cas, Michele Dei
name: Cianciolo, Simona
name: Fidilio, Annamaria
name: Lazzara, Francesca
name: Paroni, Rita
name: Pignatello, Rosario
name: Strettoi, Enrica
name: Ghidoni, Riccardo
name: Drago, Filippo
name: Bucolo, Claudio
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Myriocin is an antibiotic derived from Mycelia sterilia, and is a potent inhibitor of serine palmitoyltransferase, the enzyme involved in the first step of sphingosine synthesis. Myriocin, inhibiting ceramide synthesis, has a great potential for treatment of diseases characterized by high ceramide levels in affected tissues, such as retinitis pigmentosa (RP). Drug delivery to the retina is a challenging task, which is generally by-passed through intravitreal injection, that represents a risky invasive procedure. We, therefore, developed and characterized an ophthalmic topical nanotechnological formulation based on a nanostructured lipid carrier (NLC) and containing myriocin. The ocular distribution of myriocin in the back of the eye was assessed both in rabbits and mice using LC-MS/MS. Moreover, rabbit retinal sphingolipid and ceramides levels, after myriocin-NLC (Myr-NLC) eye drops treatment, were assessed. The results demonstrated that Myr-NLC formulation is well tolerated and provided effective levels of myriocin in the back of the eye both in rabbits and mice. We found that Myr-NLC eye drops treatment was able to significantly decrease retinal sphingolipid levels. In conclusion, these data suggest that the Myr-NLC ophthalmic formulation is suitable for pharmaceutical development and warrants further clinical evaluation of this eye drops for the treatment of RP.
Revive, Renew and Relaunch! AKTEA, the European network of women in fisheries and aquaculture, meets to revitalize the network to face current challenges
Creators: name: Frangoudes, Katia
name: Brennan, Ruth
name: Said, Alicia
name: Gustavsson, Madeleine
Publisher: name: Zenodo
Year: 2020

description: Article on the revival and relaunch of AKTEA, the European Network of Women in Fisheries and Aquaculture
Cubic and hexagonal liquid crystals as drug carriers for the transdermal delivery of triptolide
Creators: name: Shan, Qian-Qian
name: Jiang, Xiao-Jing
name: Wang, Fang-Yuan
name: Shu, Zi-Xuan
name: Gui, Shuang-Ying
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The purpose of this study was to develop and evaluate triptolide-loaded cubic and hexagonal liquid crystals for transdermal drug delivery systems (TDDSs). We prepared and characterized triptolide-loaded lyotropic liquid crystals and evaluated for their percutaneous permeation properties in vitro and in vivo. We then used the adjuvant arthritic rat model and HaCaT cells to analyze the pharmacodynamics and conduct cell-stimulating studies of these liquid crystals. The optimized preparations were identified as cubic and hexagonal phase structures, respectively. Moreover, the in vitro percutaneous penetration studies demonstrated that compared to the homemade triptolide gel, cubic and hexagonal liquid crystals could significantly increase the percutaneous cumulative penetration of drugs within 48 h. Besides, the results of skin-blood synchronous microdialysis showed that the triptolide concentration in skin was higher than that in blood, and the cubic and hexagonal liquid crystals significantly increased the bioavailability of triptolide. Triptolide-loaded cubic and hexagonal liquid crystals presented excellent anti-arthritic effects, alleviating paw swelling and inhibiting inflammation by downregulating the levels of TNF-α and IL-1β. In vitro cell-stimulating studies displayed that triptolide-loaded cubic and hexagonal liquid crystals exhibited no obvious toxicity, which exhibited that triptolide-loaded cubic and hexagonal liquid crystals were remarkable biocompatibility. Collectively, triptolide-loaded cubic and hexagonal liquid crystals represented a promising candidate for rheumatoid arthritis therapy.
Trombocitopenia Imune: Desafio Diagnóstico em Dois Lactentes
Creators: name: Sassetti, Madalena
name: Ferrito, Sofia
name: Marques, Rita
name: Franco, João
name: Malcata, Conceição
name: Braga, Manuela
Publisher: name: Portuguese Journal of Pediatrics
Year: 2018

description: A trombocitopenia imune é a causa mais comum de trombocitopenia isolada de início súbito em crianças saudáveis. Atinge sobretudo crianças entre os dois e os dez anos e constitui um diagnóstico de exclusão, sendo importante considerar outros diagnósticos perante quadros atípicos. Apresentam-se dois casos clínicos de trombocitopenia grave, particulares pela idade precoce (seis e sete semanas de vida) e pela referência em ambos à utilização de produtos anticólicas. Os dois lactentes foram internados e medicados com imunoglobulina com normalização dos valores plaquetários ao fim de uma a duas semanas. Houve resolução do quadro sem complicações graves, tendo ambos mantido seguimento em consulta após o internamento. O estudo complementar revelou anticorpos com afinidade para o simeticone nos dois casos. Embora não tenha sido possível confirmar um diagnóstico definitivo, pretende-se alertar para o desafio diagnóstico nestes casos. Immune thrombocytopenia is the leading cause of isolated thrombocytopenia in healthy children. It is seen more frequently in children aged two to ten years old. It is a diagnosis of exclusion so it is important to consider other entities, especially in atypical presentations. We present two cases of severe thrombocytopenia in small infants (six and seven weeks of age), both using anticolic medicines. The two infants were admitted and treated with intravenous immune globulin with normalization of the platelets values in one to two weeks and there was a complete resolution of the situation without severe complications. The complementary studies revealed antibodies with affinity to simethicone in both cases. Although it was not possible to confirm the diagnosis, the aim of this article is to alert to the diagnostic challenge of these cases.
description: Portuguese Journal of Pediatrics, Vol. 49 No. 3 (2018)
Recomendações Sobre a Vacina Contra Neisseria meningitidis
Creators: name: Sociedade De Infeciologia Pediátrica, Comissão De Vacinas Da
name: Pediatria, Sociedade Portuguesa De
Publisher: name: Portuguese Journal of Pediatrics
Year: 2018

description: Este trabalho sobre a vacina contra Neisseria meningitidis é o primeiro de uma série de cinco, que compõem as recomendações da Comissão de Vacinas da Sociedade de Infeciologia Pediátrica e da Sociedade Portuguesa de Pediatria, atualizadas em 2018, para vacinas não incluídas no programa nacional de vacinação. Os restantes quatro trabalhos, a publicar também na Acta Pediátrica Portuguesa abordam as vacinas contra o papiloma vírus humano no género masculino, contra rotavírus, contra a varicela e contra o vírus da hepatite A.
description: Portuguese Journal of Pediatrics, Vol. 49 No. 2 (2018)
Recomendações Sobre a Vacinação Contra o Papiloma Vírus Humano no Género Masculino
Creators: name: Sociedade De Infeciologia Pediátrica, Comissão De Vacinas Da
name: Pediatria, Sociedade Portuguesa De
Publisher: name: Portuguese Journal of Pediatrics
Year: 2018

description: Este trabalho sobre a vacinação contra papiloma vírus humano no género masculino é o segundo de uma série de cinco, que compõem as recomendações da Comissão de Vacinas da Sociedade de Infeciologia Pediatria e da Sociedade Portuguesa de Pediatria, atualizadas em 2018, para vacinas não incluídas no programa nacional de vacinação. Os restantes quatro trabalhos, publicados ou a publicar também na Acta Pediátrica Portuguesa abordam as vacinas contra Neisseria meningitidis, contra rotavírus, contra a varicela e contra o vírus da hepatite A.
description: Portuguese Journal of Pediatrics, Vol. 49 No. 2 (2018)
Intervenções no Molusco Contagioso
Creators: name: Pinto, Patricia Lipari
name: Fernandes, Ricardo M.
name: Tapadinhas, Cristina
name: Fernandes, Sónia
Publisher: name: Portuguese Journal of Pediatrics
Year: 2018

description: Portuguese Journal of Pediatrics, Vol. 49 No. 2 (2018)
Sonnenfleckenzeichnung Nr. 23375.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 17.06.1970, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1970

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt