cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Insights from Fiji’s Inaugural Graduate Outcomes Survey Part Two: Skills Gained and Levels of Preparedness for Work
Creators: name: Smyth, Roger
name: Devi, Ronika
name: Sloan, Tom
Publisher: name: Canberra, ACT: Dept. of Pacific Affairs, Research School of Pacific and Asian Studies, The Australian National University
Year: 2020

description: In 2019, the Fiji Higher Education Commission (FHEC) commissioned the inaugural Graduate Outcomes Survey (GOS) to gain insight into graduates’ careers and skills and the graduate labour market.1 Part One of this two-part series describes the GOS and reports on how well graduates meet labour market needs. This second part focuses on graduates’ assessments of the skills they gained in their studies and how well higher education prepared them for their work.
title: A Simple Synthesis of Substituted Fulvenes from 6-Fulvenyl p-Toluenesulfonates
Creators: name: Hafner, Klaus
name: Bauer, W.
name: Schulz, G.
Publisher: name: Wiley
Year: 2022

description: 6-Dimethylaminofulvene[¹] and its derivatives are useful starting materials for the preparation of non-benzenoid, cyclic, conjugated π-electron systems [²]. In the treatment of 6-fulvenyl p-toluenesulfonates with nucleophilic reagents we have found a simple process for the introduction of functional groups at the 6-position of the fulvenoid system.
One Hundred First Stars : Protostellar Evolution and the Final Masses
Creators: name: Hirano, Shingo
name: Hosokawa, Takashi
name: Yoshida, Naoki
name: Umeda, Hideyuki
name: Omukai, Kazuyuki
name: Chiaki, Gen
name: Yorke, Harold W.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We perform a large set of radiation hydrodynamics simulations of primordial star formation in a fully cosmological context. Our statistical sample of 100 First Stars show that the first generation of stars have a wide mass distribution M_popIII = 10 ~ 1000 M_sun. We first run cosmological simulations to generate a set of primordial star-forming gas clouds. We then follow protostar formation in each gas cloud and the subsequent protostellar evolution until the gas mass accretion onto the protostar is halted by stellar radiative feedback. The accretion rates differ significantly among the primordial gas clouds which largely determine the final stellar masses. For low accretion rates the growth of a protostar is self-regulated by radiative feedback effects and the final mass is limited to several tens of solar masses. At high accretion rates the protostar's outer envelope continues to expand and the effective surface temperature remains low; such protostars do not exert strong radiative feedback and can grow in excess to one hundred solar masses. The obtained wide mass range suggests that the first stars play a variety of roles in the early universe, by triggering both core-collapse supernovae and pair-instability supernovae as well as by leaving stellar mass black holes. We find certain correlations between the final stellar mass and the physical properties of the star-forming cloud. These correlations can be used to estimate the mass of the first star from the properties of the parent cloud or of the host halo, without following the detailed protostellar evolution.
description: 25 pages, 24 figures, accepted for publication in ApJ
Sławomir Wadyl (Hrsg.): Ciepłe. Elitarna nekropola wczesnośredniowieczna na Pomorzu Wschodnim / Dariusz Poliński (Hrsg.): Wczesnośredniowieczne i nowożytne cmentarzysko w Pniu / Early medieval and early modern burial site in Pień
Creators: name: Biermann, Felix
Publisher: name: Jahresschrift für mitteldeutsche Vorgeschichte
Year: 2023

description: Rezension zu: Sławomir Wadyl (Hrsg.): Ciepłe. Elitarna nekropola wczesnośredniowieczna na Pomorzu Wschodnim. Muzeum Archeologiczne w Gdańsku, Gdańsk 2019. 672 Seiten, zahlreiche Abbildungen und 61 Tafeln. Dariusz Poliński (Hrsg.): Wczesnośredniowieczne i nowożytne cmentarzysko w Pniu / Early medieval and early modern burial site in Pień. Verlag Akapit, Toruń 2020. 488 Seiten, 107 Abbildungen und 30 Tafeln.
description: Jahresschrift für mitteldeutsche Vorgeschichte, Bd. 99 (2023): Jahresschrift für Mitteldeutsche Vorgeschichte
M. G. Knight: Fragments of the Bronze Age: The Destruction and Deposition of Metalwork in South-West Britain and its Wider Context
Creators: name: Bunnefeld, Jan-Heinrich
Publisher: name: Jahresschrift für mitteldeutsche Vorgeschichte
Year: 2023

description: Rezension zu: M. G. Knight: Fragments of the Bronze Age: The Destruction and Deposition of Metalwork in South-West Britain and its Wider Context. Prehistoric Society Research Papers 13. Oxbow Books, Oxford 2022. 200 Seiten, zahlreiche Karten und SW-Abbildungen, einige Farbabbildungen.
description: Jahresschrift für mitteldeutsche Vorgeschichte, Bd. 99 (2023): Jahresschrift für Mitteldeutsche Vorgeschichte
High resolution radio emission from RCW 49/Westerlund 2
Creators: name: Benaglia, Paula
name: Koribalski, Baerbel
name: Peri, Cintia S.
name: Marti, Josep
name: Sanchez-Sutil, Juan R.
name: Dougherty, Sean M.
name: Noriega-Crespo, Alberto
Publisher: name: arXiv
Year: 2013
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: RCW49 and its ionizing cluster form an extensive, complex region, widely studied at IR and optical wavelengths. Molonglo 843 MHz and ATCA data at 1.4 and 2.4 GHz showed two shells. Recent high-resolution IR imaging revealed a complex dust structure and ongoing star formation. New high-bandwidth and high-resolution data of the RCW49 field were obtained to survey the radio emission at arcsec scale and investigate the small-scale features and nature of the HII region.- Data were collected with the new 2-GHz bandwidth receivers and the CABB correlator of the ATCA, at 5.5 and 9.0 GHz. In addition, archival observations at 1.4 and 2.4 GHz have been re-reduced and re-analyzed, together with optical, IR, X-ray, and gamma-ray observations.- The CABB data result in the most detailed radio continuum images of RCW49 to date. The radio emission closely mimics the near-IR emission observed by Spitzer, showing pillars and filaments. The brightest continuum emission comes from the region known as the bridge. The overall flattish spectral index is consistent with a free-free emission mechanism. However, hints of nonthermal components are also present in the bridge. A jet-like structure surrounded by a bubble feature whose nature is still unclear has been discovered close to the Westerlund~2 core. Two apparent bow shocks and a number of discrete sources have been detected as well in the surroundings of RCW49. We also report on and discuss the possible detection of a H RRL.- The radio results support an association between the cm continuum and molecular emission. The detection of the RRL kinematically favors a RCW49 distance of 6--7 kpc. If the negative spectral indices measured at the bridge are caused by synchrotron emission, we propose a scenario where high-energy emission could be produced. Finally, the newly discovered jet-like structure appears to deserve a detailed study by itself.
description: 12 pages, 10 figures; accepted for publication in Astronomy and Astrophysics
Designing For Accessible Sidewalk Robots – Insights From People With Motor Disabilities
Creators: name: Han, Ziyu
Publisher: name: Carnegie Mellon University
Year: 2023
Subjects: subject: 120304 Digital and Interaction Design
subject: FOS: Arts (arts, history of arts, performing arts, music)
subject: 120199 Architecture not elsewhere classified
subject: FOS: Civil engineering

description: Sidewalk robots, such as delivery robots, are becoming increasingly common worldwide, as they offer companies a more sustainable and affordable last-mile delivery service. Despite their advantages, the use of sidewalks by these robots for their operations presents challenges for other co-present sidewalk users of the shared space, especially vulnerable road users like people with motor disabilities (PWMD). These individuals have already proven to encounter more obstacles while navigating sidewalks, and the presence of sidewalk robots may exacerbate these difficulties. Therefore, there is a pressing need to investigate how the various design factors related to sidewalk robots might impact the daily navigation of people with motor disabilities. Also, as a new form of Human-robot interaction(HRI) is happening in public spaces, there is also a lack of evaluation tools to replicate the behavior of the robots and test how they alter the navigation experience of PWMD. I approached this problem through two distinct but interrelated inquiries. Firstly, a Wizard-of-Oz (WoZ) virtual simulation tool was developed to emulate and examine HRI between sidewalk users and delivery robots in street environments. Preliminary studies using this tool, both through video interviews and immersive virtual reality experiences, demonstrated its potential to foster meaningful design conversations. Subsequently, I conducted semi-structured interviews with ten PWMD to gain insights into their perceptions, interaction preferences, and attitudes towards the emerging presence of sidewalk robots. The qualitative analysis of these interviews led to the identification of 23 themes, clustered into three categories. These encompassed potential influences of sidewalk robots on PWMD, scenarios of interaction between PWMD and these robots, and emerging opportunities for design enhancement. As public spaces become increasingly populated with robots, my findings argue for the necessity of more robust evaluation tools to facilitate the design of accessible sidewalk robots that align with established social norms. Virtual simulation tools can play a pivotal role in this process, complementing real-world tests and providing crucial data to inform design decisions. The insights gleaned from my research can contribute to the development of equitable deployment guidelines for sidewalk robots and inspire further investigation into the impact of emerging public robots on vulnerable populations.
Economic evaluation of stereotactic radiotherapy and stereotactic radiosurgery technologies in the treatment of cancers: a systematic review
Creators: name: Rezapour, Aziz
name: Gholampour, Hanie
name: Barzegar, Mohammad
name: Irandoust, Kamran
name: Afshari, Somayeh
name: Arabloo, Jalal
name: Mahmoodi, Razieh
name: Asiabar, Ali Sarabi
name: Atefimanesh, Pezhman
name: Ghafoori, Mohammad Hossein
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Pharmacology
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Science Policy

description: This systematic review study investigated the cost-effectiveness of stereotactic radiotherapy (SRT) and stereotactic radiosurgery (SRS) for treatment of various types of cancers. PubMed, Scopus, and Web of Science were searched from 30 December 1990 to 1 January 2023. The entered studies were screened in accordance with the inclusion criteria. The inclusion criteria encompassed all types of economic evaluation studies that investigated SRT/SRS technologies in the treatment of various cancers. A total of 47 articles were included in the review. The findings suggest that the use of Linear accelerator technology for the treatment of lung cancer (8 out of 12 studies) and prostate cancer (4 out of 5 studies) was a cost-effective strategy. Linear accelerator was found to be cost-effective in the treatment of liver metastases and liver cancer (2 out of 5 studies). All of the included studies that used Gamma Knife technology in brain metastases reported Gamma-Knife was a cost-effective treatment. Furthermore, in the treatment of prostate and liver cancer, proton therapy was identified as a cost-effective option than other treatments. This study confirms that SRT/SRS is a cost-effective procedure for the treatment of various types of cancers. Therefore, it is recommended to use SRT/SRS technology for optimal use of resources.
Röhren- und Gefäßgewölbe bei Keramikbrennöfen und ihre Parallelen in der Großarchitektur. Ausgrabungsfunde aus Bad Schmiedeberg (Lkr. Wittenberg) in Sachsen-Anhalt als Auslöser einer archäologisch-architekturgeschichtlichen Spurensuche
Creators: name: Kluttig-Altmann, Ralf
Publisher: name: Jahresschrift für mitteldeutsche Vorgeschichte
Year: 2023

description: Jahresschrift für mitteldeutsche Vorgeschichte, Bd. 99 (2023): Jahresschrift für Mitteldeutsche Vorgeschichte
Botschaften aus Burgverliesen – spätmittelalterlich-frühneuzeitliche Ritzzeichnungen in Questenberg (Harz) und Greiffenberg (Uckermark)
Creators: name: Biermann, Felix
Publisher: name: Jahresschrift für mitteldeutsche Vorgeschichte
Year: 2023

description: Jahresschrift für mitteldeutsche Vorgeschichte, Bd. 99 (2023): Jahresschrift für Mitteldeutsche Vorgeschichte
3D Design through Interactive Training of a Generative Reinforcement Learning Agent
Creators: name: Hong, Chloe
Publisher: name: Carnegie Mellon University
Year: 2023
Subjects: subject: 120304 Digital and Interaction Design
subject: FOS: Arts (arts, history of arts, performing arts, music)
subject: 80101 Adaptive Agents and Intelligent Robotics
subject: FOS: Computer and information sciences

description: Designing is an open-ended process that involves multiple iterations of creating artifacts and evaluating them with multifaceted criteria. The challenges come from the fact that not only the artifact, but the criteria for design are gradually articulated and that they are unique to the domain, context, and designer’s intentions. Recent advancements in generative design have sought to aid the 3D design process by delegating the task of auto generating and visualizing multiple artifacts. However, these frameworks still come short by enforcing the designers to prematurely define constraints and prompting them to translate their intentions into a limited set of parametric or operational inputs which is non-trivial and confines the design to certain forms. This thesis introduces an alternative framework of 3D designing where the designer interactively trains a reinforcement learning (RL) based generative agent. It first aims to formulate a RL agent that can be trained to procedurally generate 3D forms given partial and evolving constraints. The proposed method leverages the capabilities of RL agents to procedurally generate feasible 3D forms while adapting to user-provided constraints. It also presents and experiments with an interactive framework between the designer and generative RL agent, that would allow simultaneous articulation of design criteria and artifacts, which is critical in early design development. The interactive framework allows designers to iteratively evaluate auto-generated artifacts and provide intermittent feedback that serves to articulate the implicit design criteria. As a result, this work sheds light on ways to integrate learning-based computational frameworks for idiosyncratic design tasks as well as presenting a novel mode of designing through training generative learning-based agents.
Magnetic Inhibition of Convection and the Fundamental Properties of Low-Mass Stars. I. Stars with a Radiative Core
Creators: name: Feiden, Gregory A.
name: Chaboyer, Brian
Publisher: name: arXiv
Year: 2013
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Magnetic fields are hypothesized to inflate the radii of low-mass stars---defined as less massive than 0.8$M_\odot$---in detached eclipsing binaries (DEBs). We investigate this hypothesis using the recently introduced magnetic Dartmouth stellar evolution code. In particular, we focus on stars thought to have a radiative core and convective outer envelope by studying in detail three individual DEBs: UV Psc, YY Gem, and CU Cnc. The results suggest that the stabilization of thermal convection by a magnetic field is a plausible explanation for the observed model-radius discrepancies. However, surface magnetic field strengths required by the models are significantly stronger than those estimated from the observed coronal X-ray emission. Agreement between model predicted surface magnetic field strengths and those inferred from X-ray observations can be found by assuming that the magnetic field sources its energy from convection. This approach makes the transport of heat by convection less efficient and is akin to reduced convective mixing length methods used in other studies. Predictions for the metallicity and magnetic field strengths of the aforementioned systems are reported. We also develop an expression relating a reduction in the convective mixing length to a magnetic field strength in units of the equipartition value. Our results are compared with those from previous investigations to incorporate magnetic fields to explain the low-mass DEB radius inflation. Finally, we explore how the effects of magnetic fields might affect mass determinations using asteroseismic data and the implication of magnetic fields on exoplanet studies.
description: Accepted for publication in ApJ, 25 pages, 19 figures, 6 tables. Version 2 is the final manuscript
A Hybrid Mode Model of the Blazhko Effect, Shown to Accurately Fit Kepler Data for RR Lyr
Creators: name: Bryant, Paul H.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The waveform for Blazhko stars can be substantially different during the ascending and descending parts of the Blazhko cycle. A hybrid model, consisting of two component oscillators of the same frequency, is proposed as a means to fit the data over the entire cycle. One component exhibits a sawtooth-like velocity waveform while the other is nearly sinusoidal. One method of generating such a hybrid is presented: a nonlinear model is developed for the first overtone mode, which, if excited to large amplitude, is found to drop strongly in frequency and become highly non-sinusoidal. If the frequency drops sufficiently to become equal to the fundamental frequency, the two can become phase locked and form the desired hybrid. A relationship is assumed between the hybrid mode velocity and the observed light curve, which is approximated as a power series. An accurate fit of the hybrid model is made to actual Kepler data for RR Lyr. The sinusoidal component may tend to stabilize the period of the hybrid which is found in real Blazhko data to be extremely stable. It is proposed that the variations in amplitude and phase might result from a nonlinear interaction with a third mode, possibly a nonradial mode at 3/2 the fundamental frequency. The hybrid model also applies to non-Blazhko RRab stars and provides an explanation for the light curve bump. A method to estimate the surface gravity is also proposed.
description: No major changes. Emphasizes the ability of the hybrid mode to explain changes in the pulsation waveform throughout the Blazhko cycle that may otherwise be problematic. Notes that first-overtone/fundamental combination is just one possible means to generate the hybrid and suggests alternatives. Notes similarity of bump generation in this model to the resonance mechanism in bump Cepheids
Ein mittelalterlicher Limosiner Kruzifixus aus Helfta (Mansfelder Land)
Creators: name: Biermann, Felix
Publisher: name: Jahresschrift für mitteldeutsche Vorgeschichte
Year: 2023

description: Jahresschrift für mitteldeutsche Vorgeschichte, Bd. 99 (2023): Jahresschrift für Mitteldeutsche Vorgeschichte
Application of exergy-based analysis methods for investigation of a multi-generation energy system: advantages and limitations
Creators: name: Nahan, Vontas A.
Publisher: name: University of Leicester
Year: 2022
Subjects: Uncategorized

description: Exergy-based analysis methods are often used to analyse energy conversion systems. The main aim of advanced exergy-based analysis namely advanced exergy analysis, advanced exergoeconomic analysis, and advanced exergoenvironmental analysis is to provide the energy system designers and operators with information required to improve the system. Using the advanced exergy analysis, part of the exergy destruction that cannot be avoided due to technology limitation, cost of materials or method of manufacturing could be determined. This method can also be used to determine how big is part of the exergy destruction caused by the inefficiency of the component itself or by the inefficiency of the remaining system components. Traditionally, using advanced exergy analysis, endogenous/exogenous and avoidable/unavoidable exergy destruction are assumed to be negligible in ideal conditions, even for those components where chemical reactions take place. This is not an accurate assumption. Therefore, the aim of this study is to critically evaluate the exergy-based analysis methods and propose how these methods could be improved. In this study energy and exergy-based analysis methods are introduced and improvements for advanced exergy analysis method are suggested. The improved method with new assumptions is then applied to analyse multigeneration energy conversion system. To perform this study improved advanced exergy, exergoeconomic and exergoenvironmental analysis are conducted and compared with exergy-based analysis methods. The advantages of advanced exergy analysis and limitations of the method, when the methods are being used for analysis of complex energy conversion systems are discussed. The exergy-based analysis of energy conversion system’s results depend on the choice of reference temperature. To investigate how the costs of the products of ammonia absorption chiller system varies with temperature, exergy analysis is conducted at different conditions. The results of the study show the limitations of exergoeconomic analysis method, especially when it is used for analysis of refrigeration systems.
Neue Untersuchungen zum Westbau der Klosterkirche in Goseck, Burgenlandkreis
Creators: name: Rode, Holger
Publisher: name: Jahresschrift für mitteldeutsche Vorgeschichte
Year: 2023

description: Jahresschrift für mitteldeutsche Vorgeschichte, Bd. 99 (2023): Jahresschrift für Mitteldeutsche Vorgeschichte
Baltisches aus der Börde. Eine exotische Hufeisenfibel im Nahbereich eines Fernweges
Creators: name: Muhl, Arnold
Publisher: name: Jahresschrift für mitteldeutsche Vorgeschichte
Year: 2023

description: Jahresschrift für mitteldeutsche Vorgeschichte, Bd. 99 (2023): Jahresschrift für Mitteldeutsche Vorgeschichte
Supersymmetric non-Abelian multiwaves in D=3 AdS superspace
Creators: name: Bandos, Igor A.
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present a covariant, supersymmetric and kappa-symmetric action for non-Abelian multiwave system (nAmW) in D=3 AdS superspace. Its flat superspace limit provides a simplest counterpart of the recently proposed action for 11 dimensional system of N nearly coincident M-waves (multiple M0-branes), which is presently known for the case of flat target superspace only.
description: 20 pages. V2: typos corrected, reference added. To appear in JHEP
An Exploration of Visual Approaches in Augmented Reality to Enhance Energy Conservation in Residential Spaces Leveraging the IoT Data
Creators: name: Jin, Fanjie
Publisher: name: Carnegie Mellon University
Year: 2023
Subjects: subject: 120304 Digital and Interaction Design
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: The ongoing need to increase awareness and e!orts toward energy conservation in residential spaces is underscored by a pilot study investigating individuals' general attitudes toward energy conservation. The study reveals that participants (N = 12) generally exhibit a low commitment to energy conservation, indicating a need to enhance both awareness and proactive efforts in energy saving. The broader problem lies in the absence of engaging tools and interfaces that enable users to understand and manage their energy consumption in an engaging way. This could potentially be addressed through the intervention of augmented reality (AR) and the Internet of Things (IoT). However, conventional interactions with IoT devices exhibit a limited capacity to deliver rich and contextualized user experiences. To address this issue, this thesis proposes the use of AR as a critical instrument to support the understanding of energy conditions in a residential setting. AR, with its ability to merge real objects and virtual information, presents an opportunity to enhance the depth of information displayed and facilitate engaging interactions with the environment. The research approach encompasses conducting pilot studies and leveraging the insights gained from them to consolidate the prototype direction. Through these studies, three key architectural elements are identified to promote sustainability: (1) accessibility and visibility of energy level data, (2) optimization of control mechanisms, and (3) recommendations for proactive practices. I explore both in-situ spatial mapping and the use of simulated architectural models as interaction methods to achieve the three aforementioned objectives. A speculative system in a simulated virtual reality prototype is employed to demonstrate potential applications across various scenarios. The initial attempt is presented using descriptive images to a select group of participants, followed by an analysis of preliminary findings concerning users' perceptions of the system. One preliminary finding is that both interaction methods lead to enhanced awareness of energy consumption patterns and could potentially encourage users to adopt more energy-efficient behaviors.
A cost-effectiveness analysis of reduced viral transmission with baloxavir marboxil versus oseltamivir or no treatment for seasonal and pandemic influenza management in the United Kingdom
Creators: name: Kommandantvold, Svenn Alexander
name: Lemenuel-Diot, Annabelle
name: Skedgel, Chris
name: Pitman, Richard
name: Rouse, Peter
name: Zaraket, Hassan
name: Zhou, Hao
name: Zumofen, Marie-Helene Blanchet
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Baloxavir marboxil is an oral, single-dose, cap-dependent endonuclease inhibitor that reduces the duration of influenza symptoms and rapidly stops viral shedding. We developed a susceptible, exposed, infected, recovered (SEIR) model to inform a cost-effectiveness model (CEM) of baloxavir versus oseltamivir or no antiviral treatment in the UK. The SEIR model estimated the attack rates among otherwise healthy and high-risk individuals in seasonal and pandemic settings. The CEM assumed that a proportion of infected patients would receive antiviral treatment. Results were reported at the population level (per 10,000 at risk of infection). The SEIR model estimated greater reductions in infections with baloxavir. In a seasonal setting, baloxavir provided incremental cost-effectiveness ratios (ICERs) of £1884 per quality-adjusted life-year (QALY) gained versus oseltamivir and a dominant cost-effectiveness position versus no antiviral treatment in the total population; ICERs of £2574/QALY versus oseltamivir and £128/QALY versus no antiviral treatment were seen in the high-risk population. Baloxavir was also cost-effective versus oseltamivir or no antiviral treatment and reduced population-level health system occupancy concerns during a pandemic. Baloxavir treatment resulted in the fewest influenza cases and was cost-effective versus oseltamivir or no antiviral treatment from a UK National Health Service perspective. Baloxavir marboxil (‘baloxavir’) is a prescription medicine for people who become ill with influenza (or ‘the flu’) that can reduce how long flu symptoms last and the likelihood of complications from the flu that may require going to the hospital. Baloxavir can also reduce the amount and duration of virus shed by infected individuals thus potentially slow or stop the flu from spreading to healthy people. We studied differences in reducing predicted flu infections between baloxavir and another flu treatment, known as oseltamivir, or no flu treatment at all. Treatment with baloxavir resulted in fewer flu infections in the UK population than oseltamivir or no treatment. We then studied how these differences might affect costs between baloxavir and oseltamivir or no treatment at a population level in the UK. Overall, in the majority of scenarios explored in the model, baloxavir was cost-effective as an antiviral treatment for people with the flu in the UK.
Single Molecule Spin valves
Creators: name: Olivares Peña, Jorge Enrique
Publisher: name: Karlsruher Institut für Technologie (KIT)
Year: 2022

description: Transport in the frame of the Landauer formalism for the single particle case is examined for carbon nanotubes decorated with magnetic molecules. Non-standard ab-initio calculations using constrained density functional theory to ensure the correct charge and magnetization densities are performed. Density functional calculations are performed on magnetic molecules in different spatial configurations: gas phase, crystal phase, and compound; the latter configuration type corresponds to a close-to-experiment system in which magnetic molecules are attached to a non-magnetic one. Based on the magnetization of the sitting molecules, two different magnetic states are examined. They are termed as antiparallel and parallel cases. They correspond to the experimental realizations shown elsewhere. The Kohn-Sham matrices, which are the result of the density functional simulations, are then used as an input for the transmission simulations which is performed using the Landauer formalism. Two transmission spectra are calculated corresponding to the alpha and beta spin channels per simulation. Differential conductance maps show a higher conductance for the parallel case compared to the antiparallel one for all the gate voltages where the conductance is different from zero. An empirical model is presented which mimics the real systems’ behaviour. It consists on a spin polarized tight-binding chain with two atoms per site where two defects are added to the central region simulating the real magnets. To model the CNT small bandgap, two orbitals per atom site were used. Similar results to those of the real system are calculated. It was found that the reason of the difference in conductance between one spin state and the other is that in the parallel case, the transmission for alpha and beta spin channels around the region of interest overlap giving a total transmission (which is the sum of both spins’ transmissions) larger to that of the antiparallel case where the alpha and beta transmissions are separated.
Impuls und Spaten. Ausloten, was in der Memorialkirche der Ottonen in Memleben möglich ist
Creators: name: Grönwald, Holger
name: Heikkinen, Mikko
Publisher: name: Jahresschrift für mitteldeutsche Vorgeschichte
Year: 2023

description: Jahresschrift für mitteldeutsche Vorgeschichte, Bd. 99 (2023): Jahresschrift für Mitteldeutsche Vorgeschichte
Pembrolizumab combined with chemotherapy versus placebo combined with chemotherapy for HER2-negative advanced gastric cancer in China: a cost-effectiveness analysis
Creators: name: Zheng, Zhiwei
name: Song, Xiaobing
name: Cai, Hongfu
name: Zhu, Huide
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: This study aims to conduct a cost-effectiveness analysis of pembrolizumab in combination with chemotherapy for HER2-negative advanced gastric cancer in China. A partitioned survival approach model was constructed to simulate the progression of HER2-negative advanced gastric cancer and evaluate the outcomes of different treatment strategies. We calculated incremental cost-effectiveness ratios (ICER) to assess the cost associated with each quality-adjusted life-year (QALY) gained. One-way sensitivity analysis and probabilistic sensitivity analysis were performed to assess robustness and reliability. The analysis conducted in the base case demonstrated that the ICER associated with pembrolizumab was $177405.83/QALY gained in all population. In the subgroup analysis, it was found that individuals with a PD-L1 CPS ≥ 1 and those with a PD-L1 CPS ≥ 10 had ICERs of $152397.06/QALY and $109534.13/QALY, respectively. All ICER values for both the all population groups and the subgroups exceeded the WTP threshold in China. Our analysis shows the robustness of these results, as they remained consistent when input parameters were varied within a ± 25% range. The findings of this cost-effectiveness analysis suggest that pembrolizumab in combination with chemotherapy is not a cost-effective treatment option for HER2-negative advanced gastric cancer in China.
Anamorphic transformation and its application to time-bandwidth compression
Creators: name: Asghari, Mohammad H.
name: Jalali, Bahram
Publisher: name: arXiv
Year: 2013
Subjects: subject: Optics (physics.optics)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: A general method for compressing the modulation time-bandwidth product of analog signals is introduced and experimentally demonstrated. As one of its applications, this physics-based signal grooming performs feature-selective stretch, enabling a conventional digitizer to capture fast temporal features that were beyond its bandwidth. At the same time, the total digital data size is reduced. The compression is lossless and is achieved through a same-domain transformation of the signal's complex field, performed in the analog domain prior to digitization. Our method is inspired by operation of Fovea centralis in the human eye and by anamorphic transformation in visual arts. The proposed transform can also be performed in the digital domain as a digital data compression algorithm to alleviate the storage and transmission bottlenecks associated with "big data".
description: M. H. Asghari and B. Jalali, "Anamorphic transformation and its application to time-bandwidth compression," submitted on May 28th, 2013 to Applied Optics journal- Accepted. To be presented at IEEE Photonic Conference, September 2013 and in IEEE GlobalSIP, December 2013
Prime Shred-a weight gain formula!
Creators: name: Prime Shred
Publisher: name: Zenodo
Year: 2020

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An der Grenze des karolingischen Imperiums. Das Kastell contra Magadaburg und die Ausgrabung in der Breiten Straße 34/35 in Biederitz, Lkr. Jerichower Land
Creators: name: Wehner, Donat
name: Schaller, Claudia
Publisher: name: Jahresschrift für mitteldeutsche Vorgeschichte
Year: 2023

description: Jahresschrift für mitteldeutsche Vorgeschichte, Bd. 99 (2023): Jahresschrift für Mitteldeutsche Vorgeschichte
Cost-effectiveness analysis of first-line serplulimab plus chemotherapy for advanced squamous non-small-cell lung cancer in China: based on the ASTRUM-004 trial
Creators: name: Xiang, Heng
name: Meng, Kehui
name: Wu, Meiyu
name: Tan, Chongqing
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Plant Biology
subject: FOS: Biological sciences

description: In the ASTRUM-004 trial, serplulimab plus chemotherapy demonstrated significantly improved survival and controllable safety. This study assessed the cost-effectiveness of serplulimab plus chemotherapy in advanced squamous non‐small cell lung cancer (sqNSCLC), considering the perspective of the Chinese healthcare system. A decision tree and a Markov model were constructed to simulate the treatment. The interesting results included total cost, life-years (LYs), quality-adjusted life-years (QALYs) and incremental cost-effectiveness ratios (ICERs). Scenario, one-way and probabilistic sensitivity analyses were used to examine model instability. Compared with placebo plus chemotherapy, serplulimab plus chemotherapy had an ICER of $55,539.46/QALY ($47,278.84/LY). The ICERs were estimated to be $58,706.03/QALY, $48,978.34/QALY and $59,709.54/QALY inpatients with programmed death-ligand 1 expression level of tumor proportion score (TPS) < 1%, 1% ≤ TPS < 50%, and TPS ≥ 50%. The cost-effective prices of serplulimab were $168.276/100 mg, $349.157/100 mg, and $530.039/100 mg at the willingness-to-pay threshold of $12,574.30/QALY, $25,148.60/QALY, and $37,722.90/QALY. Patient weight and price of serplulimab created the most significant impact. Presently, the probability of serplulimab plus chemotherapy being cost-effective was 14.15%. Compared with placebo plus chemotherapy, serplulimab plus chemotherapy might not be cost-effective in the first-line treatment for advanced sqNSCLC.
Transcriptome analysis of C. retusus flowers at different developmental stages in three varieties
Creators: name: 王锦楠(Wang Jinnan)
Publisher: name: CNGB
Year: 2025
Subjects: Transcriptome or Gene expression
Monoisolate

description: Transcriptomic analysis was conducted on four stages of flower development in three types of C. retusus varieties, namely straight, semi closed, and spiral twisted.
Examination of serine and threonine phosphorylation of the STAR protein Sam68
Creators: name: Lightfoot, Adam J.
Publisher: name: University of Leicester
Year: 2022
Subjects: Uncategorized

description: The signal transduction and activation of RNA (STAR) proteins are a family of proteins that contain an RNA binding STAR domain. The best characterised member of the STAR family is Sam68, a predominantly nuclear protein that can also be found in the cytoplasm where it acts as an adapter protein in various signaling cascades. One of the main biological functions of Sam68 is its role in alternative splicing of specific target genes such as CD44, cyclin D1 and Bcl-X (Frisone et al., 2015). The function of Sam68 in alternative splicing can be regulated by post-translational modifications (PTMs) such as serine/threonine phosphorylation (Matter et al., 2002) tyrosine phosphorylation (Lukong et al., 2005), arginine methylation (Côté et al., 2003) and lysine acetylation (Babic et al., 2004). The precise mapping of these PTMs on Sam68 and how they affect the function of Sam68 is currently unknown. Here, we aimed to determine site specific mapping of serine and threonine phosphorylation sites in the intrinsically disordered N-terminal domain (NTD) of Sam68 using NMR. Assignment of the N-terminal domain of Sam68 would allow measurements of NMR spectra of the protein in the presence of specific kinases as well to determine the phosphorylation sites at a residue specific level. Furthermore, we aimed to characterise the functional consequences of the phosphorylation in terms of RNA binding and splicing using a series of point mutants where targeted residues could no longer be phosphorylated. We also began preliminary studies of the STAR domain of Sam68 using in-cell NMR in collaboration Professor Yutaka Ito at Tokyo Metropolitan University, Japan.
jungbronze- und früheisenzeitlicher Salinenbetrieb aus Halle (Saale)
Creators: name: Michel, Florian
Publisher: name: Jahresschrift für mitteldeutsche Vorgeschichte
Year: 2023

description: Jahresschrift für mitteldeutsche Vorgeschichte, Bd. 99 (2023): Jahresschrift für Mitteldeutsche Vorgeschichte
Flexible Invariants Through Semantic Collaboration
Creators: name: Polikarpova, Nadia
name: Tschannen, Julian
name: Furia, Carlo A.
name: Meyer, Bertrand
Publisher: name: arXiv
Year: 2013
Subjects: subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences

description: Modular reasoning about class invariants is challenging in the presence of dependencies among collaborating objects that need to maintain global consistency. This paper presents semantic collaboration: a novel methodology to specify and reason about class invariants of sequential object-oriented programs, which models dependencies between collaborating objects by semantic means. Combined with a simple ownership mechanism and useful default schemes, semantic collaboration achieves the flexibility necessary to reason about complicated inter-object dependencies but requires limited annotation burden when applied to standard specification patterns. The methodology is implemented in AutoProof, our program verifier for the Eiffel programming language (but it is applicable to any language supporting some form of representation invariants). An evaluation on several challenge problems proposed in the literature demonstrates that it can handle a variety of idiomatic collaboration patterns, and is more widely applicable than the existing invariant methodologies.
description: 22 pages
Das Zepter in die Hand nehmen – neue Untersuchungen an der bronzezeitlichen »Keule« von Thale
Creators: name: Brendel, Sebastian
Publisher: name: Jahresschrift für mitteldeutsche Vorgeschichte
Year: 2023

description: Jahresschrift für mitteldeutsche Vorgeschichte, Bd. 99 (2023): Jahresschrift für Mitteldeutsche Vorgeschichte
Pembrolizumab combined with Chemotherapy versus placebo combined with Chemotherapy for HER2-negative advanced gastric cancer in China:A cost-effectiveness analysis
Creators: name: Zheng, Zhiwei
name: Song, Xiaobing
name: Cai, Hongfu
name: Zhu, Huide
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: This study aims to conduct a cost-effectiveness analysis of pembrolizumab in combination with chemotherapy for HER2-negative advanced gastric cancer in China. A partitioned survival approach model was constructed to simulate the progression of HER2-negative advanced gastric cancer and evaluate the outcomes of different treatment strategies. We calculated incremental cost-effectiveness ratios (ICER) to assess the cost associated with each quality-adjusted life-year (QALY) gained. One-way sensitivity analysis and probabilistic sensitivity analysis were performed to assess robustness and reliability. The analysis conducted in the base case demonstrated that the ICER associated with pembrolizumab was $177405.83/QALY gained in all population. In the subgroup analysis, it was found that individuals with a PD-L1 CPS ≥ 1 and those with a PD-L1 CPS ≥ 10 had ICERs of $152397.06/QALY and $109534.13/QALY, respectively. All ICER values for both the all population groups and the subgroups exceeded the WTP threshold in China. Our analysis shows the robustness of these results, as they remained consistent when input parameters were varied within a ± 25% range. The findings of this cost-effectiveness analysis suggest that pembrolizumab in combination with chemotherapy is not a cost-effective treatment option for HER2-negative advanced gastric cancer in China.
The equivariant cohomology rings of Peterson varieties
Creators: name: Fukukawa, Yukiko
name: Harada, Megumi
name: Masuda, Mikiya
Publisher: name: arXiv
Year: 2013
Subjects: subject: Algebraic Geometry (math.AG)
subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics
subject: 14M15, 55N91

description: The main result of this note is an efficient presentation of the $S^1$-equivariant cohomology ring of Peterson varieties (in type $A$) as a quotient of a polynomial ring by an ideal $\mathcal{J}$, in the spirit of the well-known Borel presentation of the cohomology of the flag variety. Our result simplifies previous presentations given by Harada-Tymoczko and Bayegan-Harada. In particular, our result gives an affirmative answer to a conjecture of Bayegan and Harada that the defining ideal $\mathcal{J}$ is generated by quadratics.
description: 14 pages. Minor changes made in convention and notation in order to be consistent with earlier papers in the literature
Quantum Corrections in Massive Gravity
Creators: name: de Rham, Claudia
name: Heisenberg, Lavinia
name: Ribeiro, Raquel H.
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We compute the one-loop quantum corrections to the potential of ghost-free massive gravity. We show how the mass of external matter fields contribute to the running of the cosmological constant, but do not change the ghost-free structure of the massive gravity potential at one-loop. When considering gravitons running in the loops, we show how the structure of the potential gets destabilized at the quantum level, but in a way which would never involve a ghost with a mass smaller than the Planck scale. This is done by explicitly computing the one-loop effective action and supplementing it with the Vainshtein mechanism. We conclude that to one-loop order the special mass structure of ghost-free massive gravity is technically natural.
description: v2: References added, 29 pages, 7 figures