cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Amtliche Mitteilungen der Technischen Universität Dortmund Nr. 3/2023
Creators: name: (:Unkn) Unknown
Publisher: name: Technische Universität Dortmund
Year: 2023
Subjects: subject: 080

description: Dienstvereinbarung für die Nutzung von digital-mechanischen Schließsystemen in von der TU Dortmund genutzten Räumlichkeiten
description: Wahlordnung für die Wahlen zum StuPa der Studierendenschaft der Technischen Universität Dortmund vom 07.12.2022
description: Richtlinie der Technischen Universität Dortmund für die Vergabe von Fördergeldern im Rahmen des Programms TU.hosts vom 31. Januar 2023
description: Fakultätsordnung der Fakultät Raumplanung
description: Amtliche Mitteilungen der Technischen Universität Dortmund;2023; 3
title: Checkpoint inhibitors promote immune-related adverse events trough deregulation of store-operated Ca2+ entry and ERK1/2 signalling pathway in CD4 T cells
Creators: name: Zapp, Benedikt
name: Lehmkuhl, Peter
name: Schulze-Koops, Hendrik
name: Skapenko, Alla
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Background: Anti-tumor therapy with immune checkpoint inhibitors for programmed-death 1 receptor (PD1), such as nivolumab is often accompanied by immune-related adverse events (irAE). The cellular and molecular mechanisms underlying this phenomenon are not defined yet. Interaction of PD-1 with its ligand[for full text, please go to the a.m. URL]
description: 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
title: TRPA1 and TRPM3 trigger the uptake of large cations in rheumatoid arthritis synovial fibroblasts – a new drug delivery system?
Creators: name: Lowin, Torsten
name: Schneider, Matthias
name: Pongratz, Georg
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Background: In rheumatoid arthritis (RA), synovial fibroblasts (SF) secrete pro-inflammatory cytokines and matrix degrading enzymes. Previous studies already demonstrated the functional expression of several transient receptor potential channels (TRP) such as TRPV1, TRPA1 and others in SF. Upon ligation,[for full text, please go to the a.m. URL]
description: 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Soy Phosphatidylinositol–Containing Lipid Nanoparticle Prolongs the Plasma Survival and Hemostatic Efficacy of B-domain–Deleted Recombinant Canine Factor VIII in Hemophilia A Dogs
Creators: name: Rigsbee, Natalie
name: Nichols, Timothy C.
name: Shetty, Krithika A.
name: Balu-Iyer, Sathy V.
name: Merricks, Elizabeth P.
name: Raymer, Robin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Soy phosphatidylinositol (PI) containing lipid nanoparticles prolong plasma survival, improve hemostatic efficacy, and decrease immunogenicity of human B-domain deleted Factor VIII (BDD FVIII) in Hemophilia A (HA) mice. We hypothesize that PI associated BDD FVIII is more potent than the free protein, and using mathematical modeling, have projected that PI associated BDD FVIII could be used for once-weekly prophylactic dosing in patients. To facilitate translation to the clinic, comparative plasma survival and ex vivo efficacy of PI associated recombinant canine FVIII (PI-rcFVIII) were evaluated in HA dogs. 2 HA dogs were administered a 50 U/kg iv dose of free or PI-rcFVIII. rcFVIII activity measurements and ex vivo efficacy analyses like whole blood clotting time (WBCT) and thromboelastography (TEG) were conducted on recovered plasma and whole blood samples. PI association decreased clearance (~25%) and increased plasma exposure (~1.4 fold) of rcFVIII. PI-rcFVIII treated animals had prolonged improvements in WBCTs and TEG parameters compared to free rcFVIII treated animals. Since rcFVIII is a BDD form of FVIII, these studies provide proof-of-principle that observations with human BDD FVIII in mice translate to higher animal species. Additionally, PI-rcFVIII has potential applications in canine HA management and as a bypass therapy in inhibitor-positive HA patients.
Strong field dynamo action in rapidly rotating convection with no inertia
Creators: name: Hughes, David W.
name: Cattaneo, Fausto
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Geophysics (physics.geo-ph)
subject: FOS: Physical sciences

description: The Earth's magnetic field is generated by dynamo action driven by convection in the outer core. For numerical reasons, inertial and viscous forces play an important role in geodynamo models; however, the primary dynamical balance in the Earth's core is believed to be between buoyancy, Coriolis and magnetic forces. The hope has been that by setting the Ekman number to be as small as computationally feasible, an asymptotic regime would be reached in which the correct force balance is achieved. However, recent analyses of geodynamo models suggest that the desired balance has still not yet been attained. Here we adopt a complementary approach consisting of a model of rapidly rotating convection in which inertial forces are neglected from the outset. Within this framework we are able to construct a new branch of solutions in which the dynamo generates a strong magnetic field that satisfies the expected force balance. The resulting strongly magnetized convection is dramatically different to the corresponding solutions in which the field is weak.
description: Published in Physical Review E (Rapid Communications)
Structural Analysis of Heparin-Derived 3- O -Sulfated Tetrasaccharides: Antithrombin Binding Site Variants
Creators: name: Yu, Yanlei
name: Lin, Lei
name: Liu, Jian
name: Amster, I. Jonathan
name: Zhang, Fuming
name: Zhang, Xing
name: St. Ange, Kalib
name: Agyekum, Isaac
name: Linhardt, Robert J.
name: Chen, Yin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Heparin is a polysaccharide that is widely used as an anticoagulant drug. The mechanism for heparin’s anticoagulant activity is primarily through its interaction with a serine protease inhibitor, antithrombin III (AT), that enhances its ability to inactivate blood coagulation serine proteases, including thrombin (factor IIa) and factor Xa. The AT-binding site in the heparin is one of the most well-studied carbohydrate-protein binding sites and its structure is the basis for the synthesis of the heparin pentasaccharide drug, fondaparinux. Despite our understanding of the structural requirements for the heparin pentasaccharide AT-binding site, there is a lack of data on the natural variability of these binding sites in heparins extracted from animal tissues. The present work provides a detailed study on the structural variants of the tetrasaccharide fragments of this binding site afforded following treatment of a heparin with heparin lyase II. The 5 most commonly observed tetrasaccharide fragments of the AT-binding site are fully characterized, and a method for their quantification in heparin and low-molecular-weight heparin products is described.
मुक्तिबोध की काव्य चेतना
Creators: name: प्रा.डॉ.मानीतकुमार अमृतराव वाकळे
Publisher: name: Zenodo
Year: 2022

description: भूमिका : गजानन माध्व मुक्तिबोध एक एैसे कवि है, जो आम जनता की छटपटाहट, पिडा और त्रासदी को अपने ‘काव्य’ के माध्यम से अभिव्यक्त करते है । हिंदी साहित्य में उनकी कविता ‘तारसपाक’ तथा ‘प्रयोगवाद’ के अनन्य साधरण कवि के रूप में जाने जाते है । उनका जन्म सदाहरण्‍ परिवार में होने के कारण अभावग्रस्त जीवन की अनुभूति, आर्थिक दुर्बलता का अहसास उनकी कविता में सहजतासे झलकता है । उन्होंने भारतीय माजव्यवस्थ को नजदिकसे जाना था वर्गवादी भावना, जातिवाद स्वरूप से वे अच्छी तरह से वाकिफ थे इसिलिए उनके चिंतन का रूख मार्क्सवादी बनपड़ा है । “डॉ. इन्द्रनाथ मदान के अनुसार मुक्तिबोध पर टालस्टाय, वर्गसा और मार्क्सवाद का स्पष्ट प्रभाव है । उनकी कविताओं में तथ कवीत अस्तित्वादियों के क्षणवाद के स्थान पर शाश्वत आशावाद, जीवन की विद्रुपता और क्षणभंगूरता के स्थान पर उनकी सुंदरता और गतिशीलता, निराशा के स्थान पर आस्था तथा व्यक्ति के दर्पित अहं के स्थान पर समाष्टि की चेतना चित्रित है । काव्य सृजन के प्रति उनका दृष्टिकोन सर्वदा प्रगतिशील रहा है, अंत: इन्हे आधुनिक हिंदी कविता के बाद के किसी संकरे कटघ्रेमें सीमित रखना उचित नही ।”1 वह संपूर्ण मार्क्सवादी नही है उनपर भारतीय मानवतावादी संस्कृति का प्रभाव है । इसलीए उनका दर्शन-चिंतन का स्वरूप भारतीय मानवतावादी मार्क्सवादी है । उनके चिन्तन का सर्वप्रमुख आयाम है मार्क्सवाद। मार्क्सवादी चिंतन का आधार द्वन्द्वत्मक भैतिकवाद है । अनास्था, विद्रोह एवं आत्मवादी दृष्टि उसकी प्रमुख पहचान है । मुक्तिबोध ने इनके अतिरिक्त वर्तमान जीवन की विद्रुपता को भी विभिन्न प्रकार से साकार किया है । सभ्यता और संस्कृति के मुखौटो को पहनकर शोषण और भ्रष्टाचार के मसीही षडयंत्र चक्र को अवरूध करने में कविने अपनी पुरी शक्ति लगादी है । उनके उस काव्य-प्रयास को हम एक और जहां विध्वंस चेतना का नाम दे सकते है वही मानवीय जिजीविषा भी कह सकते है, क्योंकि कवि समस्त विरोधों, विद्रोह, आक्रोश एवं क्षोभ का निष्कर्ष निराशा अथवा असहायता के होकर जीवन के साहस से जीने का परोक्ष प्रयास है । यहीं कवि मुक्तिबोध अपने समानधर्मा अन्य प्रगतिशील माक्सवादी चिंतको से अलग पहचाने जाते है । चारों और घिरे पिड़ाओं के चक्रव्यूहों के माध्यएकांकी होते हुए भी उनकी जीने की कोशिश, मानवता का एक चरम आयाम प्रस्तुत करती है । इस प्रकार उनकी चिंतन धारा को कोई एक नाम या शीर्षक नही दिया जा सकता। डॉ. नामबर सिंह के शब्दोंमें “नयी कविता में मुक्तिबोध की स्थिति वही है, जो छायावाद में निराला की थी। निराला के समान ही मुक्तिबोध ने भी अपने युग के सामान्य काव्य मूल्यों का प्रतिकात्मक करने के साथ ही उसकी सीमा को चुनौती देकर उस सर्जनात्मक विथिष्ठता के चरितार्थ किया, जिस में समकालीन काव्य का सही मुल्यांकन संभव हो सका।”2 मुक्तिबोध के चिंतन का आधार तथा काव्य की मान्यताएँ मानव है मानव को केंद्र मानकर उन्होंने काव्य की रचना की है । अपनी कविता के आधरभूत दर्शन में कुछ बुनियादी सवाल उठाए है । वो कहतें है ‘बुनियादी सवाल अपना पहचान न पाया मैने कहा “बताया है अपने उसे मैं कौन हूँ, क्या हूँ, क्यों हूँ, कैसे हूँ यह सब बताइए।” यह मानवतावादी प्रगतीशील चिंतन मुक्तिबोध की सबसे अलग पहचान कराती है।
Piper jenkinsii C. DC. Candollea
Creators: name: Mukherjee, Prasanta Kumar
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Piperales
Piperaceae
Piper
Piper jenkinsii

description: 9. Piper jenkinsii C. DC. Candollea 2: 212. 1925.
 TYPE: — INDIA, Assam: Assam, Jenkins s.n., (holotype CAL!—as to lower left one; isotype G-DC [G00315910! –pencilled sketch of the leaf by C. DC.]).
 Distribution:— INDIA: Assam.
 Note:— The specimen at CAL has C. DC.’s annotation and is considered as the holotype of the species. There are two distinct specimens on it, differing from each other in leaves. The lower left one is Piper jenkinsii with a detached female spike and the top right one with male spikes can be identified as Piper chuvya Miq. (1943: 267). Casimir de Candolle (loc. cit.) included the description of the male spike present on another specimen (CAL, 379460). This second specimen is with twigs of two different species. The twigs at the centre and on the right have leaves and male spikes of P. jenkinsii. On the right, there is a very long female spike with sub-pedicellate fruits, decurrent bracts and a detached leaf. The leaf looks similar to that of the holotype of P, crassistipes C. DC. (1925: 214) (= P. rhytidocarpum Hook. f. (1886: 92) at BO having a male spike as well as the drawing given by C. de Candolle at G-DC (G00329644 image). The annotation by de Candolle on the sheet at CAL is missing (probably lost during preservation as the lower part of the sheet is torn). It matches the description of P. crassistipes based on the presence of decurrent, adnate bracts and is presumably an isotype of that name. This species differs from P. rhytidocarpum because the leaves have suprabasal nerves that are pinnately disposed and the fruits have a thickened pseudo-pedicel. The rachis of the female spike is straight, thickened, and, with more or less 30 cm, the longest of all the Piper species from India.
description: Published as part of Mukherjee, Prasanta Kumar, 2018, Nomenclatural notes on Piper Linn. (Piperaceae) from India II, pp. 17-32 in Phytotaxa 338 (1) on page 21, DOI: 10.11646/phytotaxa.338.1.2, http://zenodo.org/record/13719121
title: Modulation of dopamine receptors on osteoblasts as a possible therapeutic strategy for inducing bone formation in arthritis
Creators: name: Salinas Tejedor, Laura
name: Rickert, Markus
name: Steinmeyer, Jürgen
name: Rehart, Stefan
name: Neumann, Elena
name: Harre, Ulrike
name: Schett, Georg
name: Müller-Ladner, Ulf
name: Capellino, Silvia
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Background: Either osteoclastic bone resorption or osteoblastic bone formation dysfunction contributes to inflammatory bone disorders including rheumatoid arthritis (RA). Current therapies target osteoclasts to reduce bone degradation, but few treatments have been developed to promote bone protection[for full text, please go to the a.m. URL]
description: 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Reactive nitrogen/oxygen species production by nitro/nitrosyl supramolecular ruthenium porphyrin complexes
Creators: name: Gonçalves,
name: Doriguetto,
name: Magno,
name: Batista,
name: Parra,
name: Silva,
name: Ellena,
name: Sampaio,
name: Neto, N.M. Barbosa
name: Correa,
name: Barbosa,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: This manuscript reports on new nitro/nitrosyl Ru-based complexes, which were synthesized with the purpose of using them as precursors to obtain supramolecular ruthenium porphyrin species ({TPyP[Ru (NO2)(5,50-Mebipy)2]4}(PF6)4) and ({TPyP[Ru(NO)(5,50-Mebipy)2]4}(PF6)12). The photochemical and photophysical properties of these porphyrin species were investigated. Results show that the complex containing nitrite is able to produce NO by homolytic O—NO cleavage (FPPh NO = 0.05) while the {TPyP[Ru (NO)(5,50-Mebipy)2]4}(PF6)12 does it by direct labilization (FPPh NO = 0.53) of the Ru NO bond. Furthermore, a triplet quantum yield of 0.09 and 0.27 was observed for complexes containing nitrite and nitric oxide, respectively. The reactive oxygen species quantum yield for the complex {TPyP[Ru(NO) (5,50-Mebipy)2]4}(PF6)12 (0.78) is consistent with the sum of quantum yields NO release (0.53) and triplet state (0.27), which suggests that both processes participate in the formation of the reactive species. Our results show that combining these characteristics, NO production and triplet states, on the same platform could induce a synergic effect, leading to a considerable improvement in the photodynamic action of these complexes.
Crusticorallina gen. nov., a nongeniculate genus in the subfamily Corallinoideae (Corallinales, Rhodophyta)
Creators: name: Gabrielson, Paul W.
name: P. Jensen, Cassandra
name: Hind, Katharine R.
name: Martone, Patrick T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Molecular phylogenetic analyses of 18S rDNA (SSU) gene sequences confirm the placement of Crusticorallina gen. nov. in Corallinoideae, the first non-geniculate genus in an otherwise geniculate subfamily. Crusticorallina is distinguished from all other coralline genera by the following suite of morpho-anatomical characters: 1) sunken, uniporate gametangial and bi/tetrasporangial conceptacles, 2) cells linked by cell fusions, not secondary pit connections, 3) an epithallus of 1 or 2 cell layers, 4) a hypothallus that occupies 50% or more of the total thallus thickness, 5) elongate meristematic cells, 6) trichocytes absent. Four species are recognized based on rbcL, psbA and COI-5P sequences, C. painei sp. nov., the generitype, C. adhaerens sp. nov., C. nootkana sp. nov. and C. muricata comb. nov., previously known as Pseudolithophyllum muricatum. Type material of Lithophyllum muricatum, basionym of C. muricata, in TRH comprises at least two taxa, and therefore we accept the previously designated lectotype specimen in UC that we sequenced to confirm its identity. Crusticorallina species are very difficult to distinguish using morpho-anatomical and/or habitat characters, although at specific sites, some species may be distinguished by a combination of morpho-anatomy, habitat and biogeography. The Northeast Pacific now boasts six coralline endemic genera, far more than any other region of the world. This article is protected by copyright. All rights reserved.
Hamilton dynamics for the Lefschetz thimble integration akin to the complex Langevin method
Creators: name: Fukushima, Kenji
name: Tanizaki, Yuya
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: The Lefschetz thimble method, i.e., the integration along the steepest descent cycles, is an idea to evade the sign problem by complexifying the theory. We discuss that such steepest descent cycles can be identified as ground-state wave-functions of a supersymmetric Hamilton dynamics, which is described with a framework akin to the complex Langevin method. We numerically construct the wave-functions on a grid using a toy model and confirm their well-localized behavior.
description: 11 pages, 4 figures; (v2) Secs. 2 and 4 are improved, Fig. 4 is added, References are updated
A Practical CFD Philosophy for Computing Liquid-Induced Energy Dissipation and Pressure Distributions for Aircraft Design
Creators: name: Wright, Michael
Publisher: name: Zenodo
Year: 2023

description: The drive for a more environmentally sustainable aviation industry has led to the requirement for improved aircraft structural weight optimisation. A limiting factor in achieving this is the current over-conservatism in estimating slosh-induced energy dissipation and pressure distributions. The over-conservatism is due to the vast range of operational conditions to be considered during design, while very few viable loads estimation techniques are available. This thesis addresses the latter via a novel yet practical CFD-based loads estimation philosophy. This work will be limited to vertical slosh excitations. To this end, this work will employ experimentally validated CFD as an ideally suited and versatile tool to characterise liquid slosh-induced loads and energy dissipation. It is thus first demonstrated that a FVM-VOF based CFD scheme employing a weaklycompressible gas formulation is capable of computing violent slosh-induced energy dissipation with high accuracy (a 98% correlation with experimental data is achieved). By employing non-dimensional analysis, a functional relationship characterising slosh-induced energy dissipation is formulated in terms of fluid physics-based non-dimensional numbers. Accurate CFD analyses are consequently employed to develop novel scaling laws (curve fits) that quantify energy dissipation as a function of selected fluid physics nondimensional numbers and geometric scaling. The practical use of the developed scaling laws is next demonstrated by quantifying slosh loads for perfect Froude scaled experiments (with exact fluid physics similarity to the full-scale aircraft) and full-scale systems (practical and achievable Froude scaled experiments) from slosh experiments to an accuracy of 91% and 87% respectively. The CFD-derived energy dissipation scaling-laws may now be employed within the industry standard full aircraft model (FAM), which employs proprietary ROMs for the structure, aerodynamics and slosh loads. This yields improved global slosh loads but still provides very limited information regarding tank-wall pressure distributions, which negates structural component optimisation. This is addressed via a CFD-based coarse mesh ROM which is non-linear and mass and momentum conservative. The novel Pressure Distribution ROM involves a coarse mesh CFD which is tuned to match input target loads via the automated adjustment of liquid properties, which constitutes the final contribution of this work. It is demonstrated that the new Pressure ROM is capable of computing tank wall pressures and slosh-induced damping to engineering precision while being significantly faster to run as compared to detailed CFD. Keywords: Full Aircraft Model (FAM); Multi-phase Flows; Non-dimensional Analysis; Violent Slosh-induced Energy Dissipation; Volume of Fluid (VOF) method; Finite vi Volume Method (FVM); Computational Fluid Dynamics (CFD); Reduced-order Model (ROM)
Dielectric function and plasmons in graphene: A self-consistent-field calculation within a Markovian master equation formalism
Creators: name: Karimi, F.
name: Davoody, A. H.
name: Knezevic, I.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Other Condensed Matter (cond-mat.other)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We introduce a method for calculating the dielectric function of nanostructures with an arbitrary band dispersion and Bloch wave functions. The linear response of a dissipative electronic system to an external electromagnetic field is calculated by a self-consistent-field approach within a Markovian master equation formalism (SCF-MMEF) coupled with full-wave electromagnetic equations. The SCF-MMEF accurately accounts for several concurrent scattering mechanisms. The method captures interband electron-hole-pair generation, as well as the interband and intraband electron scattering with phonons and impurities. We employ the SCF-MMEF to calculate the dielectric function, complex conductivity, and loss function for supported graphene. From the loss-function maximum, we obtain plasmon dispersion and propagation length for different substrate types [nonpolar diamondlike carbon (DLC) and polar SiO$_2$ and hBN], impurity densities, carrier densities, and temperatures. Plasmons on the two polar substrates are suppressed below the highest surface phonon energy, while the spectrum is broad on the nonpolar DLC. Plasmon propagation lengths are comparable on polar and nonpolar substrates and are on the order of tens of nanometers, considerably shorter than previously reported. They improve with fewer impurities, at lower temperatures, and at higher carrier densities.
Supplement to 'Patrick Matthew's synthesis of catastrophism and transformism from PATRICK MATTHEW'S SYNTHESIS OF CATASTROPHISM AND TRANSFORMISM
Creators: name: Dagg, Joachim L.
name: Derry, J. F.
Publisher: name: The Royal Society
Year: 2022
Subjects: History

description: Part 1 analyses and criticises the historiography on Patrick Matthew of Gourdiehill (Walther MAy, W.T. Calman, various forest scientists, Loren Eiseley, W.J. Dempster). Part 2 provides evidence showing that the records of the University of Edinburgh refer to namesakes of Patrick Matthew of Gourdiehill.
title: Increase of aerobic glycolysis mediated by activated T Helper Cells drives Synovial Fibroblasts towards an inflammatory phenotype
Creators: name: Kvacskay, Peter
name: Souto-Carneiro, Margarida
name: de Albuquerque Carvalho, Rui
name: Schnotz, Jürgen-Heinz
name: Krienke, Stefan
name: Klika, Karel D.
name: Tretter, Theresa
name: Lorenz, Hanns-Martin
name: Tykocinski, Lars-Oliver
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Background: There is growing evidence for a dysregulated glucose metabolism of synovial fibroblasts (SF) in rheumatoid arthritis (RA) being a prerequisite for their aggressive phenotype. As yet, little is known about the influence of immune cells on the metabolism of SF although local infiltration of[for full text, please go to the a.m. URL]
description: 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
title: Regulation and function of TNF family member receptors and ligands in rheumatoid arthritis synovial fibroblasts
Creators: name: Lowin, Torsten
name: Schneider, Matthias
name: Pongratz, Georg
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Background: Rheumatoid arthritis (RA) synovial fibroblasts (SF) show an activated, invasive phenotype which is accompanied by copious production of pro-inflammatory cytokines. In addition, RASF have been shown to stimulate B cell survival by the production of BAFF (CD257). While the role for TNF family[for full text, please go to the a.m. URL]
description: 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
The Higgs boson structure functions as signposts of new physics
Creators: name: Gounaris, G. J.
name: Renard, F. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We show that the Higgs boson structure functions observable in the inclusive process $e^-e^+ \to H + {\rm "anything"}$ may reveal the presence of anomalous contributions corresponding to several types of new physics partners, Higgs boson compositeness or invisible (dark) matter. This could be done without making a difficult or even an impossible experimental analysis of the contents of the "anything". We give illustrations showing how the shapes of the various structure functions containing such typical new contributions may differ from the standard prediction and allow their identification.
description: 19 pages, 36 figures, version accepted in Phys. Rev. D
Piper suipigua Buch.
Creators: name: Mukherjee, Prasanta Kumar
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Piperales
Piperaceae
Piper
Piper suipigua

description: 20. Piper suipigua Buch. -Ham ex D. Don Prodr. Fl. Nepal. 20. 1825.
 Type:— NEPAL. Hamilton s.n. (holotype BM000950698 image!; isotype G-DC G00206597 image!).
 Piper nepalense Miq. Syst. Piperac. 318, 1844.
 Type:— NEPAL. Nepal, Piper peepuloides Wallich 6650 B (lectotype designated here U1476540 image!; isolectotype K000794463 image!, G00206597 image!, CAL!).
 Piper nepalense var. parvifolium C. DC. Prodr. 16: 358. 1869 syn. nov.
 Type:— INDIA. Meghalaya, Khasia, 4000ft. J. D. H. & T. T. (holotype G-DC G0026596 image! –lower plant; isotypes G-DC G00206595 image!, CAL!; syntypes P iper 20, Sikkim, J. D. H. s. n. G-DC G00206594 image!).
 Piper gamblei C. DC. (1925: 208) syn. nov.
 Type:— INDIA: Darjeeling, 7000ft. J. S. Gamble 8364 (holotype CAL!; isotype K00794451 image!).
 Piper gammiei C. DC. (1925: 202) syn. nov.
 Type:— INDIA: Assam, Makum Dihing river, G. A. Gammie 5 (holotype CAL!).
 Piper sikkimense C. DC. (1925: 199) syn. nov.
 Type:— INDIA: Sikkim, Unknown Collector s. n. (holotype CAL!; isolectotype CAL!).
 Piper subrigidilimbum C. DC. (1925: 201) syn. nov.
 Type:— INDIA, Lebong, Darjeeling, 5000ft. J. S. Gamble 9692 (holotype CAL!; isotype K000794450 image!).
 Distribution:— INDIA: West Bengal, Sikkim, Assam, Arunachal Pradesh, Meghalaya, Manipur; NEPAL; BHUTAN; CHINA.
 Note:— This species is the most common one in Nepal, Sikkim, and Meghalaya. Wallich 6650B at U (1476540) is designated here as the lectotype of P. nepalense because this particular sheet bears Miquel’s annotation with the mention of the name Piper peepuloides Roxb. and Miquel worked principally on specimens at U. Specimens at K and G-DC have annotations in Miquel’s handwriting, yet the name Piper peepuloides is missing in these. The type of Piper nepalense var. crassifolium C. DC. (1868: 358) could not be traced. It appears to be not much different, yet it is excluded from consideration here. The original material of Piper nepalense var. parvifolium shows very strong nerves but otherwise it is the same as P. suipigua. Most of the other synonyms included here follow Long (1984: 350) except P. japvonum, which is considered presently as a distinct species. Piper glabramentum is considered in this study as a synonym of P. rhytidocarpum. Piper gamblei C. DC. forma b C. DC. (1925: 208) and Piper gamblei C. DC. forma c C. DC. (1925: 208) cannot be considered valid names, but the material cited for the two as present at CAL is similar to P. suipigua.
description: Published as part of Mukherjee, Prasanta Kumar, 2018, Nomenclatural notes on Piper Linn. (Piperaceae) from India II, pp. 17-32 in Phytotaxa 338 (1) on page 28, DOI: 10.11646/phytotaxa.338.1.2, http://zenodo.org/record/13719121
The Role of Stress in Understanding Differences in Sedentary Behavior in Hispanic/Latino Adults: Results from the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study
Creators: name: Strizich, Garrett
name: Marshall, Simon J.
name: Penedo, Frank J.
name: Murillo, Rosenda
name: Isasi, Carmen R.
name: Shaw, Benjamin A.
name: Salazar, Christian
name: Sotres-Alvarez, Daniela
name: Merchant, Gina C.
name: Gallo, Linda
name: Vásquez, Elizabeth
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Chronic stress and/or lifetime traumatic stress can create a self-reinforcing cycle of unhealthy behaviors, such as overeating and sedentary behavior, that can lead to further increases in stress. This study examined the relationship between stress and sedentary behavior in a sample of Hispanic/Latino adults (N = 4244) from the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study.
title: CTLA-4-Ig treatment induces modulation of B-cell function and differentiation
Creators: name: Lorenzetti, Raquel
name: Venhoff, Nils
name: Janowska, Iga
name: Voll, Reinhard
name: Walter, Lea
name: Staniek, Julian
name: Smulski, Cristian R.
name: Rizzi, Marta
name: Thiel, Jens
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Background: CTLA-4 modulates T-cell activation by inducing inhibitory signaling in T-cells. To date the direct effect of CTLA-4-Ig (abatacept) on B-cells has not been studied in detail. We hypothesize that CTLA-4 modulates B-cell function, B-cell homeostasis and B-cell receptor signaling in a T-cell-dependent[for full text, please go to the a.m. URL]
description: 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Ternary adsorbent photocatalyst hybrid (APH) nanomaterials for improved abstraction of tetracycline from water
Creators: name: Minallah, Sammar
name: Pervaiz, Erum
name: Yousaf, M. Usman
name: Niazi, M. Bilal Khan
name: Honghong, Liu
name: Yang, Minghui
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Space Science
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Current health situations have instigated increased frequency of taking antibiotics for cure of infections but this amplified use is posing threats to environment. This research is focused to remove Tetracycline (TC), an antibiotic from water, using an advanced nanohybrid that compact the properties of adsorbent and photocatalyst. Compared to conventional methods for remediation of TC, large surface area (452 m2g−1) adsorbent photocatalyst hybrid (APH) g-C3N4/α-MoO3/ZIF-67 (CMZ) have found much effective as 97% degradation of TC is observed in 110 min with 0.1 g of APH. Increasing g-C3N4 in the hybrids has improved percent degradation of TC molecules. CMZ-3 is found as a potential candidate for water treatment.
Removal of phenol and Bisphenol A by immobilized Laccase on poly (Acrylonitrile-co-Styrene/Pyrrole) nanofibers
Creators: name: El-Aassar, M. R.
name: Alsohaimi, Ibrahim Hotan
name: Ali, Ahmed S. M.
name: Elzain, Ahmed A.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Enzymatic oxidative polymerization of phenol and Bisphenol A (BPA) catalyzed by Laccase enzyme immobilized into poly (Acrylonitrile-co-Styrene/Pyrrole) nanofibers (AN-co-ST/Py) in an aqueous solution was investigated in a batch adsorption mode. The prepared poly (AN-co-ST/Py) copolymeric material was electrospun to nanofibers via electrospinning technique. Gas chromatography/mass spectrometry (GC-MS) was used to detect the residual phenol and BPA in the aqueous medium after the removal process. Optimization of solution’s pH, temperature, initial concentration of phenolic pollutants, and amount of adsorbent and agitation speed was investigated. The results showed that the removal of phenol and BPA by Laccase in the immobilized form was higher than that in the free form.The optimum removal by the immobilized form was achieved at these conditions (Temp: 50°C, pH: 5, Agitation rate: 120 rpm, Contact time: 120 min).
Hkkjrh; fQYe m|ksx & ,d ,sfrgkfld voyksdu
Creators: name: MkW- Jkts'k EkS;Z1 Izks- Ts- Ih- FeÙky2
Publisher: name: Zenodo
Year: 2022

description: lkj%& Hkkjr esa fQYe ;k flusek yksxksa ds fy;s euksjatu ds lkFk&lkFk muds thou dk ,d vfHkUu vax jgk gSa] D;ksafd flusek us izkphu Hkkjrh; laLd`fr] lH;rk vkSj lkekftd thou ls le;≤ ij ifjfpr djk;k gSaA Hkkjrh; fQYe m|ksx] tks fd Hkkjr dh okf.kT; dgs tkus okys “kgj eqEcbZ esa fLFkr gSa] ckWyhoqM ds uke ls tkus tkrh gSaA ;g uke nks “kCnksa ckWyh$gkWyhcqM] ls feydj cuk gSaA ;gkW ckWyh dk eryc ckWEcs ¼eqEcbZ ls iwoZ dgk tkus okyk uke½ vkSj gkWyhoqM fons”kksa esa cuus okyh fQYeksa ds fy;s ,d pfpZr uke gSa] blhfy;s bls ckWyhoqM dgk tkrk gSa ijUrq Hkkjr esa dsoy fgUnh Hkk’kk dh gh fQYesa ugha curh cfYd dbZ vU; jkT;h; ;k {ks=h; Hkk’kkvksa esa Hkh cgqr cM+s iSekus ij fQYeksa dk fuekZ.k fd;k tkrk gSaA ftUgsa vyx&vyx ukeksa tSls rfey ¼dkWyhoqM½] rsyxw ¼VkWyhoqM½] fgUnh ¼ckWyhoqM½ vkfn ls lacksf/kr fd;k tkrk gSaA buesa ls lcls vf/kd fQYeksa dk fuekZ.k dkWyhoqM esa gksrk gSa] ysfdu ckWDl vkWfQl ij lQyrk rFkk fcØh ds ekeysa esa fgUnh Hkk’kk dh fQYesa vxz.kh gSa] ftUgsa u dsoy Hkkjrh; n”kZd ilan djrs gSa cfYd fons”kksa esa fuokljr izoklh Hkh ilan djrs gSaA
Walking and Walkability: Is Wayfinding a Missing Link? Implications for Public Health Practice
Creators: name: Hunter, Rebecca H.
name: Anderson, Lynda A.
name: Bryant, Lucinda L.
name: Hooker, Steven P.
name: Satariano, William A.
name: Vandenberg, Ann E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Research on walking and walkability has yet to focus on wayfinding, the interactive, problem-solving process by which people use environmental information to locate themselves and navigate through various settings.
title: Simulating the pathogenesis of arthritis in vitro by developing a human-based multicomponent 3D joint model
Creators: name: Damerau, Alexandra
name: Lang, Annemarie
name: Ehlers, Lisa
name: Pfeiffenberger, Moritz
name: Gaber, Timo
name: Buttgereit, Frank
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Background: Our ultimate goal is to develop a valid human in vitro 3D joint model to simulate the pathogenesis of arthritis. The in vitro 3D joint model consists of different components including an (1) osteogenic and (2) chondrogenic part, (3) the joint space with synovial fluid and (4) the synovial[for full text, please go to the a.m. URL]
description: 46. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 32. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)
Piper voigtii C. DC. Linnaea
Creators: name: Mukherjee, Prasanta Kumar
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Piperales
Piperaceae
Piper
Piper voigtii

description: 22. Piper voigtii C. DC. Linnaea 37: 365. 1872.
 Type:— INDIA: India Orientale, Voigt s. n. (holotype C 10013882 image!).
 Piper mungpooanum C. DC. Candollea 2: 192. 1925 syn. nov.
 Type:— INDIA: Sikkim (West Bengal!), Mungpoo peak, King 2481 (holotype CAL!).
 Piper ovatoacuminatum C. DC. Candollea 2: 195. 1925 syn. nov.
 Type:— INDIA: Sikkim, Collector unknown s. n. (holotype CAL!).
 Distribution: — INDIA. West Bengal. Sikkim.
 Note: —An examination of this material reveals little differences among the specimens, and as such all three are synonymized. The species has some similarity to the foliage of P. attenuatum and P. sylvaticum. From the first one, it differs in the nature of the bract being peltate orbicular and from the second, in the form of leaf base being shallowly cordate and the very short spikes which are more or less equal in length to the petioles.
description: Published as part of Mukherjee, Prasanta Kumar, 2018, Nomenclatural notes on Piper Linn. (Piperaceae) from India II, pp. 17-32 in Phytotaxa 338 (1) on pages 29-30, DOI: 10.11646/phytotaxa.338.1.2, http://zenodo.org/record/13719121
Generation of large-scale magnetic fields by small-scale dynamo in shear flows
Creators: name: Squire, Jonathan
name: Bhattacharjee, Amitava
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Fluid Dynamics (physics.flu-dyn)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: We propose a new mechanism for turbulent mean-field dynamo in which the magnetic fluctuations resulting from a small-scale dynamo drive the generation of large-scale magnetic fields. This is in stark contrast to the common idea that small-scale magnetic fields should be harmful to large-scale dynamo action. These dynamos occur in the presence of large-scale velocity shear and do not require net helicity, resulting from off-diagonal components of the turbulent resistivity tensor as the magnetic analogue of the "shear-current" effect. Given the inevitable existence of non-helical small-scale magnetic fields in turbulent plasmas, as well as the generic nature of velocity shear, the suggested mechanism may help to explain generation of large-scale magnetic fields across a wide range of astrophysical objects.
Isotemporal Analysis of the Association of Objectively Measured Physical Activity With Depressive Symptoms: Results From Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Creators: name: Buelna, Christina
name: Daviglus, Martha L.
name: Rethorst, Chad D.
name: Khan, Unab I.
name: Stoutenberg, Mark
name: Arredondo, Elva M.
name: Moncrieft, Ashley E.
name: Perreira, Krista M.
name: Gellman, Marc D.
name: Sotres-Alvarez, Daniela
name: Castañeda, Shelia F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: The burden of depression among Hispanics/Latinos indicates the need to identify factors related to depressive symptoms. This paper examines the relationship of physical activity (PA) and sedentary behavior (SB) with depressive symptoms in Hispanic/Latinos.
Piper wallichii Hand.
Creators: name: Mukherjee, Prasanta Kumar
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Piperales
Piperaceae
Piper
Piper wallichii

description: 23. Piper wallichii (Miq.) Hand. -Mazz. Symb. Sin. 7: 155. 1929.
 Basionym:— Chavica wallichii Miq. Syst. Piperac. 254. 1843.
 Type:— NEPAL. Nepal, 1821, Wallich 6658 A (lectotype designated K0007944619 image!; isolectotype U1476587 image!, G-DC G00206603 image!, K000794468 image!, CAL!; syntype BANGLADESH, Sylhet Wallich 6658 B CAL!).
 Piper aurantiacum Wall. ex C. DC. Prodr. 16: 357 1869 nom. illegt.
 Piper accrescens Van Heurck & Müll. Arg. Piperaceae novae 118. 1871 syn. nov.
 Type:— INDIA. India Orientale, Griffith 1203 (holotype BR14904 image!; isotype G-DC G00317397 image!).
 Piper caudilimbum C. DC. Candollea 2: 206. 1925 syn. nov.
 Type:— BANGLADESH. East Bengal, Griffith 4417 (lectotype designated here CAL!; isotype K00079442 image!; syntype Assam, Sypuva, Masters s. n. CAL!).
 Distribution:— INDIA: Meghalaya, Arunachal Pradesh, Manipur; BANGLADESH, CHINA, NEPAL.
 Note:— The specimen at U (U1476587 ) bearing annotation by Miquel as Chavica wallichii would have been a better choice for the lectotype. Casinir de Candolle (1925: 206) mentioned the Griffith 4417 specimen at CAL as one of the types of P. caudilimbum. As this has a complete plant with mature female spikes and similar in every respect to P. wallichii, it is designated as the lectotype. Leaves are caudate at apex in this species and both the male and female spikes are long and flexuous. While describing P. accrescens, Van Heurck & Müll. Arg. (1870: 118) commented that their species was not much different from P. aurantiacum.
description: Published as part of Mukherjee, Prasanta Kumar, 2018, Nomenclatural notes on Piper Linn. (Piperaceae) from India II, pp. 17-32 in Phytotaxa 338 (1) on page 30, DOI: 10.11646/phytotaxa.338.1.2, http://zenodo.org/record/13719121
Maximal energy extraction under discrete diffusive exchange
Creators: name: Hay, Michael J.
name: Schiff, Jeremy
name: Fisch, Nathaniel J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: Waves propagating through a bounded plasma can rearrange the densities of states in the six-dimensional velocity-configuration phase space. Depending on the rearrangement, the wave energy can either increase or decrease, with the difference taken up by the total plasma energy. In the case where the rearrangement is diffusive, only certain plasma states can be reached. It turns out that the set of reachable states through such diffusive rearrangements has been described in very different contexts. Building upon those descriptions, and making use of the fact that the plasma energy is a linear functional of the state densities, the maximal extractable energy under diffusive rearrangement can then be addressed through linear programming.
description: 8 pages, 5 figures
Superparamagnetic nanocomposites derived from waste polyurethane foam for the removal of Rhodamine B: batch and continuous column studies
Creators: name: Shivaprasad, P.
name: Kaushik, S.
name: Sivasamy, A.
name: Nethaji, S
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified

description: The present study is aimed at the utilization of waste polyurethane (PU) foam derived magnetized carbon material for the treatment of simulated dye effluent. Activated carbon (AC) was prepared from waste PU foam by chemical activation method using K2CO3. The surface of the prepared AC was incorporated with nano-sized iron oxide particles to aid the recovery of the spent adsorbent. The polyurethane derived AC-iron oxide (PUAC-Fe3O4) nanocomposites were characterized with FE-SEM, XRD, Vibrating Sample Magnetometer (VSM), FT-IR, TGA, surface area and point of zero charge. The morphology of the prepared AC had an extremely porous texture which was incorporated with iron oxide nanoparticles of size less than 100 nm with a surface area of 250 m2/g. The nanocomposites had superparamagnetic properties as evident from the VSM plot. The prepared PUAC-Fe3O4 nanocomposites was used for the removal of Rhodamine B (RB) dye. Batch adsorption studies were performed and the equilibrium parameters were calculated by fitting the data with Langmuir and Freundlich isotherm models. The thermodynamic parameters were also evaluated. The adsorption of RB dye onto PUAC-Fe3O4 composites was spontaneous and endothermic. Kinetic studies were also carried out and the data were tested with different kinetic models. Intraparticle diffusion model and Boyd plots suggested that the boundary layer diffusion step controlled the rate of adsorption. Continuous column studies were also performed and it proved that 1 g of prepared material was able to treat 1.075 L of 10 mg/L RB dye with an efficiency of 64.87%. The interferential effect of the electrolytes on the RB dye removal was also studied. Reusability studies proved that the prepared PUAC-Fe3O4 nanocomposites was efficient even after three cycles of operation.
Thermal properties of the Rényi entropies of free bosons and fermions
Creators: name: Drut, Joaquín E.
name: Porter, William J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: We generalize techniques previously used to compute ground-state properties of one-dimensional noninteracting quantum gases to obtain exact results at finite temperature. We compute the order-n Rényi entropy to all orders in the fugacity in one, two, and three spatial dimensions. In arbitrary spatial dimensions, we provide closed-form expressions for its virial expansion up to next-to-leading order. In all of our results, we find explicit volume scaling in the high-temperature limit.
दलित साहित्य में अम्बेडकर का वैचारिक अवदान
Creators: name: निर्मल सुवासिया
Publisher: name: Zenodo
Year: 2022

description: यह बात शत-प्रतिशत सही है कि दलित साहित्य ने अपने समय और समाज को जिस सच्चाई के साथ चित्रित किया है, किसी साहित्य और साहित्यकार ने नहीं की इसलिए वैचारिक दृष्टि से देखा जाय तो यह साहित्य अब तक का सबसे यथार्थवादी साहित्य है। 'दलित' शब्द व दलित साहित्य को परिभाषित कर देने के बाद यह अपने आप में संकुचित और सीमित रूप ले लेता है। 'दलित' शब्द का वास्तविक अर्थ है दबाया हुआ, कुचला हुआ जिसे सदियों से दबाया गया हो अथवा जिसे बढ़ने या पनपने न दिया गया हो। लेकिन परम्परा के अनुसार जिसे हम शूद्र या अछूत कहते हैं उसी अर्थ में हम आज दलित को देखते हैं या यूँ कहे कि देखने लगे हैं। शूद्र को दलित का पर्याय मान लेने के बाद रूढ़िगत हिन्दू समाज के अंधविश्वासों का शिकार, हजार वर्षों से अछूत का जीवन जीने वाला दीन-हीन व्यक्ति का चित्र हमारे सामने उपस्थित होता है। जिसने धर्म के नाम पर बर्बर यातनाएँ झेली हैं। अस्पृश्यता के विष को पिया है। इसलिए उन्हें अछूत, अन्त्यज, शूद्र आदि नाम दिये गये। जहाँ तक हम बात करें दलित साहित्य पर दलित रचनाकारों की तो उनका दृष्टिकोण गैर दलित साहित्यकारों से भिन्न होता है उनके विचार में ओमप्रकाश वाल्मीकि जी का कहना है कि “दलितों से सहानुभूति रखने वाले सवर्णों का दृष्टिकोण सिर्फ दया का होता है, जिसके पीछे वे अपराध बोध के स्वर को तीखा नहीं होने देते।”[i] [i] जनमत, 1-15 सितम्बर, 1994