cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Fast, Exact Bootstrap Principal Component Analysis for p > 1 million
Creators: name: Caffo, Brian
name: Zipunnikov, Vadim
name: Fisher, Aaron
name: Schwartz, Brian
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Biotechnology
subject: Neuroscience
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Medicine

description: Many have suggested a bootstrap procedure for estimating the sampling variability of principal component analysis (PCA) results. However, when the number of measurements per subject (p) is much larger than the number of subjects (n), calculating and storing the leading principal components from each bootstrap sample can be computationally infeasible. To address this, we outline methods for fast, exact calculation of bootstrap principal components, eigenvalues, and scores. Our methods leverage the fact that all bootstrap samples occupy the same n-dimensional subspace as the original sample. As a result, all bootstrap principal components are limited to the same n-dimensional subspace and can be efficiently represented by their low dimensional coordinates in that subspace. Several uncertainty metrics can be computed solely based on the bootstrap distribution of these low dimensional coordinates, without calculating or storing the p-dimensional bootstrap components. Fast bootstrap PCA is applied to a dataset of sleep electroencephalogram recordings (p = 900, n = 392), and to a dataset of brain magnetic resonance images (MRIs) (p ≈ 3 million, n = 352). For the MRI dataset, our method allows for standard errors for the first 3 principal components based on 1000 bootstrap samples to be calculated on a standard laptop in 47 minutes, as opposed to approximately 4 days with standard methods.
Optical redistribution of microparticles and cells between microwells
Creators: name: Baumgartl, Jörg
name: Hannappel, Gregor M.
name: Stevenson, David J.
name: Day, Daniel
name: Gu, Min
name: Dholakia, Kishan
Publisher: name: Swinburne
Year: 2024

description: The shaping of laser beams has developed into a powerful tool for optical micromanipulation. In this context, Airy and parabolic laser beams which follow curved trajectories have drawn considerable attention. These beams may allow clearing of microparticles through particle transport along curved paths, a concept termed 'optically mediated particle clearing (OMPC).' In this communication we apply this concept to microparticles and cells within specially designed microwells. Our results open novel perspectives for the redistribution of cells between different media within a microfluidic environment.
Application of the multireference equation of motion coupled cluster method, including spin–orbit coupling, to the atomic spectra of Cr, Mn, Fe and Co
Creators: name: Zhebing Liu
name: Huntington, Lee M.J.
name: Nooijen, Marcel
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Mathematics
subject: FOS: Mathematics
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Physiology
subject: Molecular Biology
subject: Physics

description: The recently introduced multireference equation of motion (MR-EOM) approach is combined with a simple treatment of spin–orbit coupling, as implemented in the ORCA program. The resulting multireference equation of motion spin–orbit coupling (MR-EOM-SOC) approach is applied to the first-row transition metal atoms Cr, Mn, Fe and Co, for which experimental data are readily available. Using the MR-EOM-SOC approach, the splittings in each L-S multiplet can be accurately assessed (root mean square (RMS) errors of about 70 cm−1). The RMS errors for J-specific excitation energies range from 414 to 783 cm−1 and are comparable to previously reported J-averaged MR-EOM results using the ACESII program. The MR-EOM approach is highly efficient. A typical MR-EOM calculation of a full spin–orbit spectrum takes about 2 CPU hours on a single processor of a 12-core node, consisting of Intel XEON 2.93 GHz CPUs with 12.3 MB of shared cache memory.
Experimental study of EEG and BOLD responses to sinusoidal contrast modulation
Creators: name: Ferree, T. C.
name: Wade, A. R.
name: Calvisi, M. L.
name: Szeri, A. J.
name: Liley, David
name: Inglis, B. A.
name: Norcia, A. M.
Publisher: name: Swinburne
Year: 2024

description: This paper reports pilot experiments and modeling studies on the dynamics of the BOLD response to sinusoidal input. Steady-state visual evoked potentials were generated with a contrast-reversing grating. The absolute contrast of the grating was modulated sinusoidally, across a range of frequencies relevant to block and event-related designs. The amplitude of the neural response was found to track the stimulus closely, with some interesting differences at higher frequencies. The BOLD responses were quasi-sinusoidal, without the onset or offset transients typical in block designs. A hemodynamic model, based upon the balloon model with delayed compliance, and a linear model of inward flow, was fit to the BOLD data using the contrast waveform as input. The hemodynamic model fit the BOLD data well, but required different model parameters for each stimulus frequency. This implies that the differential equations comprising the hemodynamic model do not capture adequately the dynamics of the BOLD response across multiple time scales.
Nonparametric and Parametric Estimators of Prevalence From Group Testing Data With Aggregated Covariates
Creators: name: Delaigle, Aurore
name: Zhou, Wen-Xin
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Group testing is a technique employed in large screening studies involving infectious disease, where individuals in the study are grouped before being observed. Parametric and nonparametric estimators of conditional prevalence have been developed in the group testing literature, in the case where the binary variable indicating the disease status is available only for the group, but the explanatory variable is observed for each individual. However, for reasons such as the high cost of assays, the confidentiality of the patients, or the impossibility of measuring a concentration under a detection limit, the explanatory variable is observable only in an aggregated form and the existing techniques are no longer valid. We develop consistent parametric and nonparametric estimators of the conditional prevalence in this complex problem. We establish theoretical properties of our estimators and illustrate their practical performance on simulated and real data. We extend our techniques to the case where the group status is measured imperfectly, and to the setting where the covariate is aggregated and the individual status is available. Supplementary materials for this article are available online.
Examining the ground and first excited states of methyl peroxy radical with high-level coupled-cluster theory
Creators: name: Copan, Andreas V.
name: Schaefer, Henry F.
name: Agarwal, Jay
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Peroxy radicals (RO2) are intermediates in fuel combustion, where they engage in efficiency-limiting autoignition reactions. They also participate in atmospheric chemistry leading to the formation of unwanted tropospheric ozone. Advances in spectroscopic techniques have allowed for the possibility of employing the lowest () electronic transition of RO2 as a tool to selectively monitor these species, enabling accurate kinetic values to be obtained. Herein, high-level ab initio methods are employed to systematically refine spectroscopic predictions for the methyl peroxy radical (CH3O2), one of the most abundant peroxy radicals in the atmosphere. In particular, vibrationally corrected geometries and anharmonic vibrational frequencies for both the ground () and first excited () state are predicted using coupled-cluster theory with up to perturbative triples [CCSD(T)] and large atomic natural orbital basis sets. Equation-of-motion coupled-cluster theory is utilised to compute vertical transition properties; a radiative lifetime of 4.7 ms is suggested for the excited state. Finally, we predict the adiabatic excitation energy (T0) via systematic extrapolation to the complete basis limit of coupled-cluster with up to full quadruples (CCSDTQ). After accounting for several approximations, and including an anharmonic zero-point vibrational energy correction, we match experiment for this transition to within 9 cm−1.
Convex Banding of the Covariance Matrix
Creators: name: Bien, Jacob
name: Bunea, Florentina
name: Xiao, Luo
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: We introduce a new sparse estimator of the covariance matrix for high-dimensional models in which the variables have a known ordering. Our estimator, which is the solution to a convex optimization problem, is equivalently expressed as an estimator that tapers the sample covariance matrix by a Toeplitz, sparsely banded, data-adaptive matrix. As a result of this adaptivity, the convex banding estimator enjoys theoretical optimality properties not attained by previous banding or tapered estimators. In particular, our convex banding estimator is minimax rate adaptive in Frobenius and operator norms, up to log factors, over commonly studied classes of covariance matrices, and over more general classes. Furthermore, it correctly recovers the bandwidth when the true covariance is exactly banded. Our convex formulation admits a simple and efficient algorithm. Empirical studies demonstrate its practical effectiveness and illustrate that our exactly banded estimator works well even when the true covariance matrix is only close to a banded matrix, confirming our theoretical results. Our method compares favorably with all existing methods, in terms of accuracy and speed. We illustrate the practical merits of the convex banding estimator by showing that it can be used to improve the performance of discriminant analysis for classifying sound recordings. Supplementary materials for this article are available online.
title: Temporal Graphs
Creators: name: Akrida, E
Publisher: name: University of Liverpool Repository
Year: 2016

description: This thesis studies Temporal Graphs, also called Temporal Networks. More specifically, the project aimed to carry out research on the properties of Temporal Graphs, both in general and in specific classes of the model, as well as examine and develop algorithms for solving problems in temporal graph theory. Temporal graphs are graphs that change -often dramatically- as time progresses, however maintaining a fixed number of vertices. We investigate a range of different temporal graph models depending on the way these changes occur, e.g., in a deterministic or probabilistic fashion, in a discrete-time or continuous-time context, etc. In particular, we examine connectivity matters in a model of temporal graphs where changes happen at random discrete moments in time. Within this framework, we also investigated a model of continuous time and developed algorithms that solve connectivity problems in that model. Furthermore, we study temporal network design issues for the discrete-time model of temporal graphs, both in cases where changes happen deterministically and in cases where changes happen at random discrete-time moments. We also introduce and investigate temporal network flows, where we define the problem of computing a maximum flow in a given temporal network and discuss efficient ways of solving it.
Examining the ground and first excited states of methyl peroxy radical with high-level coupled-cluster theory
Creators: name: Copan, Andreas V.
name: Schaefer, Henry F.
name: Agarwal, Jay
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Chemistry
Earth and Environmental Sciences
Physics
Biophysics

description: Peroxy radicals (RO2) are intermediates in fuel combustion, where they engage in efficiency-limiting autoignition reactions. They also participate in atmospheric chemistry leading to the formation of unwanted tropospheric ozone. Advances in spectroscopic techniques have allowed for the possibility of employing the lowest () electronic transition of RO2 as a tool to selectively monitor these species, enabling accurate kinetic values to be obtained. Herein, high-level ab initio methods are employed to systematically refine spectroscopic predictions for the methyl peroxy radical (CH3O2), one of the most abundant peroxy radicals in the atmosphere. In particular, vibrationally corrected geometries and anharmonic vibrational frequencies for both the ground () and first excited () state are predicted using coupled-cluster theory with up to perturbative triples [CCSD(T)] and large atomic natural orbital basis sets. Equation-of-motion coupled-cluster theory is utilised to compute vertical transition properties; a radiative lifetime of 4.7 ms is suggested for the excited state. Finally, we predict the adiabatic excitation energy (T0) via systematic extrapolation to the complete basis limit of coupled-cluster with up to full quadruples (CCSDTQ). After accounting for several approximations, and including an anharmonic zero-point vibrational energy correction, we match experiment for this transition to within 9 cm−1.
title: Modelling Colour Appearance: Applications in Skin Image Perception
Creators: name: Chauhan, T
Publisher: name: University of Liverpool Repository
Year: 2016

description: Humans are trichromatic, and yet their perception of colours is rich and complex. The research presented in this thesis explores the process of colour appearance of uniform patches and natural polychromatic stimuli. This is done through the measurement and analysis of the achromatic locus (Chapter 2), modelling of chromatic adaptation in a large dataset of unique hues settings (Chapter 3), and measurement of thresholds for uniform and polychromatic stimuli derived from simulated skin images (Chapter 4). Chapter 2 proposes a novel navigation scheme based on unique hues for traversing colour space. The results show that when colour adjustments are made using this novel scheme, the variability of achromatic settings made by observers is reduced compared to the classical method of making colour adjustments along the cardinal axes of the CIELUV colour space. This result holds across the tested luminance levels (5,20,50 cd/m^2) in each of the three tested ambient illumination conditions – dark, simulated daylight and cool white fluorescent lighting. The analysis also shows that the direction of maximum variance of the achromatic settings lies along the daylight locus. Chapter 3 evaluates models of chromatic adaptation by using unique hues settings measured under different ambient illumination conditions. It is shown that a simple diagonal model in cone excitation space is the most efficient in terms of the trade-off between accuracy and degrees of freedom. It is also found that diagonal and linear models show similar performances, reiterating their theoretical equivalence. Performances of these diagonalisable models are found to be worse for UR and UG unique hue planes compared to UY and UB planes. Chapter 4 presents a set of three experiments reporting estimations of perceptual thresholds for polychromatic and uniform stimuli in a 3-D chromaticity-luminance colour space. The first experiment reports thresholds for simulated skin images and uniform stimuli of the corresponding mean CIELAB colour. The second and third experiments investigate the effect of ambient illumination and the location of the stimuli in colour space. The thresholds for the polychromatic stimuli are found to be consistently higher than those for the uniform patches, for both the chromatic, and the luminance projections. The area of the chromaticity ellipses shows a gradual increase with distance from the illuminant chromaticity. The orientations of these ellipses for simulated skin are found to align with the vector joining the mean patch chromaticity and the illuminant chromaticity.
Nonparametric and Parametric Estimators of Prevalence From Group Testing Data With Aggregated Covariates
Creators: name: Delaigle, Aurore
name: Zhou, Wen-Xin
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Group testing is a technique employed in large screening studies involving infectious disease, where individuals in the study are grouped before being observed. Parametric and nonparametric estimators of conditional prevalence have been developed in the group testing literature, in the case where the binary variable indicating the disease status is available only for the group, but the explanatory variable is observed for each individual. However, for reasons such as the high cost of assays, the confidentiality of the patients, or the impossibility of measuring a concentration under a detection limit, the explanatory variable is observable only in an aggregated form and the existing techniques are no longer valid. We develop consistent parametric and nonparametric estimators of the conditional prevalence in this complex problem. We establish theoretical properties of our estimators and illustrate their practical performance on simulated and real data. We extend our techniques to the case where the group status is measured imperfectly, and to the setting where the covariate is aggregated and the individual status is available. Supplementary materials for this article are available online.
title: Μελέτη προβλημάτων τεχνητής νοημοσύνης με τη χρήση μαρκοβιανών διαδικασιών αποφάσεων
Creators: name: Κοντογεωργακης Αλεξανδρος
Publisher: name: Technical University of Crete
Year: 2024

description: Τα τελευταία χρόνια υπήρξε μια τεράστια ανάπτυξη στον τομέα της τεχνολογίας. Πολλές εφαρμογές έχουν αντικατασταθεί από την τεχνολογία, η οποία έχει βοηθήσει σημαντικά στην εξέλιξη και στην βελτίωση των συνθηκών του ανθρώπου. Η Τεχνητή Νοημοσύνη (Artificial Intelligence) είναι μια από τις τεχνολογικές καινοτομίες που συνέβησαν, για να αντικαταστήσουν την επέμβαση του ανθρώπου σε πολλές δραστηριότητες και διαδικασίες λήψης αποφάσεων. Με τον όρο τεχνητή νοημοσύνη, θεωρείται ο τομέα της επιστήμης των υπολογιστών που ασχολείται με τον σχεδιασμό συστημάτων καθώς και την υλοποίηση που μπορούν να εξομοιώσουν γνωστικές ικανότητες του ανθρώπου σε πολύ μεγάλο βαθμό.
Στόχος της παρούσας μεταπτυχιακής διατριβής είναι η μοντελοποίηση και επίλυση προβλημάτων της Τεχνητής Νοημοσύνης στο πλαίσιο που παρέχουν οι Μαρκοβιανές Διαδικασίες Αποφάσεων. Αρχικά, θα παρουσιαστούν κάποιες βασικές έννοιες της Τεχνητής Νοημοσύνης (Artificial Intelligence) καθώς και της Ενισχυτικής μάθησης (Reinforcement Learning). Στην συνέχεια θα παρουσιαστούν οι βασικές έννοιες και οι αλγόριθμοι των Μαρκοβιανών Διαδικασιών Αποφάσεων. Θα μελετηθούν κάποιες εφαρμογές όπως για παράδειγμα η διαδικασία έρευνας και διάσωσης με ένα μη επανδρωμένο ελικόπτερο σε ένα άγνωστο περιβάλλον με σκοπό την εύρεση της βέλτιστης ζώνης προσγείωσης για την εκτέλεση της αποστολής του και θα παρουσιαστούν οι αλγόριθμοι που έχουν αναπτυχθεί για την επίλυση του παραπάνω προβλήματος.
Nonparametric and parametric estimators of prevalence from group testing data with aggregated covariates
Creators: name: Delaigle, Aurore
name: Zhou, Wen-Xin
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Ecology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Genetics
subject: Medicine

description: Group testing is a technique employed in large screening studies involving infectious disease, where individuals in the study are grouped before being observed. Parametric and nonparametric estimators of conditional prevalence have been developed in the group testing literature, in the case where the binary variable indicating the disease status is available only for the group, but the explanatory variable is observed for each individual. However, for reasons such as the high cost of assays, the confidentiality of the patients, or the impossibility of measuring a concentration under a detection limit, the explanatory variable is observable only in an aggregated form and the existing techniques are no longer valid. We develop consistent parametric and nonparametric estimators of the conditional prevalence in this complex problem. We establish theoretical properties of our estimators and illustrate their practical performance on simulated and real data. We extend our techniques to the case where the group status is measured imperfectly, and to the setting where the covariate is aggregated and the individual status is available.
Unveiling the Dark Side of Social Media: Understanding Its Adverse Effects on Individuals and Society
Creators: name: Dr. Rekha Khandelwal
Publisher: name: Zenodo
Year: 2024

description: Social media has become an integral part of modern society, shaping how we communicate, share information, and interact with one another. While celebrated for its connectivity and accessibility, there is a growing awareness of the negative consequences associated with its use. This quantitative research delves into the adverse effects of social media on both individuals and society, employing statistical analysis to uncover patterns and trends. By examining data related to addiction, mental health, misinformation, and societal polarization, this study aims to provide empirical insights into the magnitude and scope of these detrimental impacts. Through rigorous quantitative methods, we seek to illuminate the dark side of social media and advocate for strategies to mitigate its harmful effects.
THE EXCITED ELECTRONIC STATES AND THE OSCILLATOR STRENGHT CALCULATED FOR FLATTENED CYLINDRICAL Cd1-xZnxS QUANTUM DOTS
Creators: name: Marzougui, Saber
name: Safta, Nabil
name: International Journal Of Chemistry And Materials Research
Publisher: name: figshare
Year: 2015
Subjects: subject: 20203 Particle Physics
subject: FOS: Physical sciences
subject: Applied Physics
subject: Condensed Matter Physics

description: The present paper is aimed to investigate theoretically the quantum confinement in Cd1-xZnxS – related quantum dots with x the atomic fraction of Zn.
Elucidating the mechanism of the palladium-catalysed decarboxylative asymmetric allylic alkylation of alpha-sulfonyl anions
Creators: name: Bowen, Eleanor
Publisher: name: Lancaster University
Year: 2020

description: This research project focused on the investigation of the palladium-catalysed decarboxylative asymmetric allylic alkylation (Pd-DAAA) reaction of α-anions of a 5-membered sulfone, sulfolane, bearing a range of ketone and ester anion stabilising substituents, in the presence of the (S,S)-ANDEN Phenyl Trost ligand. In the first instance, the synthesis of the prerequisite substrates for the Pd-DAAA reaction, namely a sulfone bearing allyl ester and phenyl ester substituents, and a sulfone bearing allyl ester and phenyl ketone substituents, was optimised. A mechanistic study followed, and it was discovered that substrates containing a 2-methyl substituted allyl ester were less reactive than their non-substituted counterparts, making these intermediates unsuitable for enolate crossover studies. Instead, 2 H-labelling of the allylic ester was achieved in good yield with 93% deuterium incorporation at the terminal alkene position. Enolate crossover reactions of both ester and ketone deuterated and non-deuterated substrates showed significant crossover, suggesting that an outer-sphere alkylation mechanism operates for both ester and ketone substrates. Relative stereochemistry determination experiments were attempted to conclusively establish the mechanism of the Pd-DAAA of cyclic sulfones, using cis-5-phenyl-2-cyclohexen-1-ol as the allylic stereochemical label. Although benzyl ester and phenyl ketone precursors were successfully prepared, they were found to be unreactive in the Pd-DAAA process, even over an extended reaction time with temperatures up to 120 °C. Optimisation of the Pd-DAAA of cyclic sulfones was explored by testing the use of additives, in an effort to increase the observed enantioselectivity. Ultimately, no increase in enantioselectivity was observed as compared to previously optimised additive-free conditions. Using these conditions, the substrate scope of the Pd-DAAA reaction was substantially broadened for a range of not only 5- but also 6-membered cyclic sulfones with varying ester and ketone substituents, affording novel enantioenriched alkylated products with 10-94% ee.
LET-559: Section 106 Tribal Consulation Letter for the IRP Site SD024 Soil Excavations and Building 11193 Demolition Project (1102583)
Creators: name: Zalud, Arianna
Year: 2018

description: This letter initiates Section 106 consultation with the SYBCI for the IRP Site SD024 Soil Excavations and Building 11193 Demolition Project. The letter seeks comments for any tribal comment or concerns associated with this project.
RISIS DATASETS TUTORIALS: CIB2
Creators: name: Laurens, Patricia
Publisher: name: Zenodo
Year: 2020
Subjects: CIB2
tutorials
R&D performers
patents
corporate invention

description: This report provides a basic tutorial for users of the Corporate Invention Board (CIB2) database, designed for the analysis of technological knowledge creation of the worldwide top corporate R&D performers, using patents as a proxy.
Iron-catalyzed spirocyclization project
Creators: name: Michalska, Weronika
Publisher: name: Lancaster University
Year: 2020

description: This project focuses on iron-catalysed heterospirocyclization reactions of aryl iodide substrates using Grignard reagents. Specifically, alkyl Grignard reagents were used, in an extension to previous work using aryl Grignard reagents. The first stage of the project included the formation of heterospirocycles from 2-[(2-iodophenoxy)methyl]-furan (X=O) in the presence of alkyl Grignard reagents. Optimisation of the reaction was not successful, but yielded six novel heterospirocycles in low yield (5-35 %). Next, new amine (X=N) systems were designed to undergo the spirocyclization reaction. However, none of the pathways were successful. Thirdly, the project included the design and synthesis of novel vinyl iodide reagents. The vinyl iodine reagent underwent the spirocyclization reaction in the presence of phenylmagnesium bromide (PhMgBr) to yield five novel heterospirocycles in 5-50% yield.
düşük hapı 0543 529 72 06 düşük yapma ilacı
Creators: name: 0543 529 72 06 whatsApp sipariş, düşük hapı eczane
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 300101
subject: Agricultural biotechnology diagnostics (incl. biosensors)
classificationCode: 300102
subject: Agricultural marine biotechnology
classificationCode: 300103
subject: Agricultural molecular engineering of nucleic acids and proteins

description: Düşük Hapı Sipariş 0543 529 72 06 Kürtaj Hapı Sipariş Çocuk Düşürme Cytotec Sipariş Bebek Düşürme Haplı Kürtaj Tıbbi WhatsApp Sipariş :
HIZLI VE GİZLİ GÖNDERİM
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DESTEK VE BİLGİLENDİRMEWebsite üzerinde, Cytotec ilacının doğru ve güvenli kullanımı hakkında bilgileri bulabilirsiniz. Olası sorunlar ve yan etkiler konusunda bilgilendirilir, aklınıza takılan sorular için destek alabilirsiniz.
Recycling and reuse of metal powders for various applications in additively manufactured products
Creators: name: Powell, Dan
Publisher: name: Lancaster University
Year: 2020
Subjects: Additive Manufacturing
Powder Degradation
Waste Recycling
Plasma Spheroidisation
Upcycling
Ball Milling

description: Additive manufacturing has the potential to create almost no waste; only material that is required for the component (and any support structures) is used in the build process. Despite this, large quantities of metal powders are sent to landfill every year due to powder degradation, caused by continual reuse of the powder. An understanding of powder formation and degradation has been presented in an extensive literature review, enabling the viability of potential waste-reducing solutions to be assessed. Plasma spheroidisation is identified as a promising method of upcycling end-of-life powders, likely to reduce powder waste by 80%. An experimental procedure was established to allow future investigation into this technology. Sustainable powder manufacturing methods were identified as under-researched. A method of breaking down support structures in powders through shear shredding and ball milling was shown to consume less energy than current virgin powder production methods. The powder produced was of a lower quality than virgin powders used in selective laser melting; further refining of the milling procedure is likely to improve this powder quality. The work done showed improvements in both resource and energy efficiency, although developing these processes beyond proof of concept remains a challenge.
Sustainable Accelerators Report
Creators: name: I.FAST WP11 members
Publisher: name: Zenodo
Year: 2025

description: WP11 reviews new developments on energy-efficient and sustainable accelerator concepts, fostering related technologies and strategies for operation through networking and collaborations. Technologies with potential for improving energy efficiency include efficient RF power sources, power converters and power quality compensators, accelerator magnets based on permanent magnet material, superconducting cables and magnets. Another focus was set on overarching ecological concepts, which is a rapidly evolving issue in the global RI field and need further development. It will help identify the most promising directions of R&D and to formulate best practices for the construction of new facilities, thus supporting all other part of this WP11.

WP11 also includes the design and prototype construction in industry of an efficient klystron RF power source as a replacement for LHC, and the development of Permanent Magnet (PM) combined magnets that could dramatically decrease power consumption of future storage-ring based synchrotron light sources.
The physics of AGN jets revealed by full-Stokes monitoring at mm and cm wavelengths
Creators: name: Myserlis, Ioannis
Publisher: name: Zenodo
Year: 2024
Subjects: subject: AGN jets
subject: polarization
subject: linear
subject: circular
subject: monitoring
subject: IRAM 30m telescope
subject: Submillimeter Array (SMA)
subject: Effelsberg telescope
subject: Active Galactic Nuclei
subject: Radio astronomy
subject: Extragalactic astronomy
subject: Adverse drug reactions

description: Poster presented at the conference "XVI Reunión Científica de la SEA", held in Granada (Spain) in July 2024, at the "Galaxias" parallel session.
description: Title: The physics of AGN jets revealed by full-Stokes monitoring at mm and cm wavelengths

Author list: Ioannis Myserlis, Ivan Agudo, Clemens Thum, Ramprasad Rao, Daniel Homan, Svetlana Jorstad, Alan Marscher, Alex Kraus, Emmanouil Angelakis

Abstract:

Jets of Active Galactic Nuclei (AGN) comprise the most energetic, long-term phenomenon in the Universe. They emerge from the vicinity of Super Massive Black Holes (SMBHs) and propagate with relativistic velocities, as high as 0.9998c, to distances much greater than their host galaxies, even > 1 Mpc. In the case of blazars, these jets are closely aligned to our line of sight (< 5º), which results in extreme boosting of their emission, making them ideal targets to study the jet physics in detail. Magnetic fields are thought to play a key role in the jet production, acceleration and collimation and they are also responsible for the observed linear and circular polarization.

In addition, blazars exhibit flaring events across the electromagnetic spectrum with timescales ranging from months down to minutes. The mechanisms that have been proposed to explain this variability, e.g. relativistic shocks or magnetic reconnection, predict distinct polarization variability characteristics. Therefore, dense monitoring of the linear and circular polarization emission from AGN jets is a powerful tool to disentangle these processes and study the physical conditions in AGN jets.

Here I will give an overview of blazar variability at mm and cm wavelengths, both in total flux and polarization, as revealed by dedicated, long-term, high-cadence monitoring programs running at several large radio facilities around the globe. I will discuss the challenges involved to achieve robust calibration and deliver high-precision, multi-frequency, full-Stokes radio data trains and showcase the jet physical conditions and variability mechanism characteristics that can be constrained using them. Finally, I will present selected examples of time domain studies of AGN jets and demonstrate how they are augmented by the combined analyses using high angular resolution radio images and concurrent observations in other bands.
A 0.4-mm-diameter probe for nonlinear optical imaging
Creators: name: Bao, Hongchun
name: Gu, Min
Publisher: name: Swinburne
Year: 2024

description: A miniaturized probe that possesses a diameter of 0.4 mm is developed for two-photon-excited fluorescence imaging. The miniaturized probe was manufactured by the collapse of air holes and the formation of a lens on the tip of a double-clad photonic crystal fiber (DCPCF) using electric arc discharging from a conventional fusion splicer. As a result, a femtosecond pulsed laser beam delivered by the DCPCF can be directly focused on a sample for two-photon fluorescence imaging. The numerical aperture of the lensed DCPCF is 0.12. The corresponding focal spot size is 6 µm, which is close to the diffraction limit. This 0.4-mm-diamter probe can provide clear two-photon-excited fluorescence images of 10-µm-diameter fluorescent microspheres.
Assessing End of Phase 2 Decision Criteria
Creators: name: Sabin, Tony
name: Matcham, James
name: Copas, Andrew
name: Parmar, Mahesh K. B.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Statistics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Earth and Environmental Sciences

description: The objectives of the Phase 2 stage in a drug development program are often to evaluate the safety and tolerability of different doses, select a promising dose range, and look for early signs of activity (i.e., to establish proof of concept). At the end of Phase 2 (EOP2), a decision to initiate Phase 3 studies is made that involves the commitment of considerable resources. One of the key factors in this decision is the expected efficacy and the associated predicted probability of success (PoS) in Phase 3. Making a decision based upon the PoS requires decision makers to select a benchmark (or PoS criterion) for the PoS, which if achieved would enable a “go-to-Phase 3” decision. However, appropriately choosing the criterion requires knowledge of the operating characteristics associated with the decision criteria. A key operating characteristic that a funder/sponsor requires to make such a choice is to understand the predicted conditional probability of making a go decision and subsequently failing in Phase 3. In this article, we show how such risks can be informed through the use of clinical trial simulation. We also highlight through a worked example in pancreatic cancer how this simulation exercise can help to decide between different development strategies for a specific indication. Supplementary materials for this article are available online.
Use of radially polarized beams in three-dimensional photonic crystal fabrication with the two-photon polymerization method
Creators: name: Jia, Baohua
name: Kang, Hong
name: Li, Jiafang
name: Gu, Min
Publisher: name: Swinburne
Year: 2024

description: Radially polarized ultrafast laser beams are used in the fabrication of three-dimensional photonic crystals with the two-photon polymerization technique in organic-inorganic hybrid materials. It has been found that when a radially polarized beam is employed, the lateral size of the fabricated polymer rods is decreased by 27.5% from 138 to 100 nm under a threshold fabrication condition, leading to a 17.35% reduction in the filling ratio of the photonic crystal. A comparison of the stop gaps between radially polarized and linearly polarized beam illumination shows a higher suppression ratio in transmission and a wider wavelength range in the former case owing to the favorable tuning of the filling ratio of the three-dimensional photonic crystals.
MYCNOS functions as an antisense RNA regulating MYCN
Creators: name: Vadie, Nadia
name: Saayman, Sheena
name: Lenox, Alexandra
name: Ackley, Amanda
name: Clemson, Mathew
name: Burdach, Jon
name: Hart, Jonathan
name: Vogt, Peter K
name: Morris, Kevin V
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Computational Biology
subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Meta Science
subject: Molecular Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biochemistry

description: Amplification or overexpression of neuronal MYC (MYCN) is associated with poor prognosis of human neuroblastoma. Three isoforms of the MYCN protein have been described as well as a protein encoded by an antisense transcript (MYCNOS) that originates from the opposite strand at the MYCN locus. Recent findings suggest that some antisense long non-coding RNAs (lncRNAs) can play a role in epigenetically regulating gene expression. Here we report that MYCNOS transcripts function as a modulator of the MYCN locus, affecting MYCN promoter usage and recruiting various proteins, including the Ras GTPase-activating protein-binding protein G3BP1, to the upstream MYCN promoter. Overexpression of MYCNOS results in a reduction of upstream MYCN promoter usage and increased MYCN expression, suggesting that the protein-coding MYCNOS also functions as a regulator of MYCN ultimately controlling MYCN transcriptional variants. The observations presented here demonstrate that protein-coding transcripts can regulate gene transcription and can tether regulatory proteins to target loci.
Optical "snowblowing" of microparticles and cells in a microfluidic environment using Airy and parabolic wavepackets
Creators: name: Baumgartl, Jörg
name: Hannappel, Gregor M.
name: Stevenson, David J.
name: Mazilu, Michael
name: Day, Daniel
name: Gu, Min
name: Dholakia, Kishan
Publisher: name: Swinburne
Year: 2024

description: The year 2007 witnessed the experimental realization of extraordinary laser beams termed Airy and parabolic beams. Surprisingly, these beams are immune to diffraction and in addition exhibit transverse acceleration while propagating. This peculiar property of both Airy and parabolic beams facilitates the clearance of both microparticles and cells from a region in a sample chamber through particle/cell transport along curved trajectories. We term this concept 'Optically mediated particle clearing' (OMPC) and, alternatively, 'Optical redistribution' (OR) in the presence of a microfluidic environment, where particles and cells are propelled over micrometersized walls. Intuitively, Airy and parabolic beams act as a form of micrometer-sized 'snowblower' attracting microparticles or cells at the bottom of a sample chamber to blow them in an arc to another region of the sample. In this work, we discuss the performance and limitations of OMPC and OR which are currently based on a single Airy beam optionally fed by a single parabolic beam. A possible strategy to massively enhance the performance of OMPC and OR is based on large arrays of Airy beams. We demonstrate the first experimental realization of such arrays.
Mapping multi-day GPS data: a cartographic study in NYC
Creators: name: Duncan, Dustin T.
name: Seann D. Regan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Neuroscience
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: 60506 Virology
subject: Computational Biology

description: Multi-day Global Positioning System (GPS) data are increasingly being used in research – including in the field of spatial epidemiology. We present several maps as ways to present multi-day GPS data. Data come from the NYC Low-Income Housing, Neighborhoods and Health Study (n = 120). Participants wore a QStarz BT-Q1000XT GPS device for about a week (mean: 7.44, SD = 2.15). Our maps show various ways to visualize multi-day GPS data; these data are presented by overall GPS data, by weekday/weekend and by day of the week. We discuss implications for each of the maps.
Pristine Animal World v/s Degenerated Humanity
Creators: name: Jayshree S.
name: Priyanka S.
Publisher: name: gjrpublication
Year: 2024

description: This research scrutinizes the intricate relationship between humans and animals, investigating the evolving dynamics shaped by their interactions. The protection and welfare of animals are intertwined with human perceptions, influenced by biological and behavioral resemblances. Positive human-animal interactions contribute to well-being, but the modern era's progress is marred by the exploitation of animal resources, raising ethical concerns. Focusing on Jack London's works, especially "To Build a Fire" and "The Call of The Wild," reveals the stark disparity between man and animal, emphasizing resilience and instincts. Mark Bennet Feldman's insights highlight the overlooked connection with animals, pivotal in human evolution. This research advocates for a paradigm shift, urging consideration of the consequences of human actions on the animal world to unravel destructive dominator cultures, economic disparities, and political power structures.
Assessing End of Phase 2 Decision Criteria
Creators: name: Sabin, Tony
name: Matcham, James
name: Copas, Andrew
name: Parmar, Mahesh K. B.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Statistics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Earth and Environmental Sciences

description: The objectives of the phase 2 stage in a drug development program are often to evaluate the safety and tolerability of different doses, select a promising dose range, and look for early signs of activity (i.e., to establish proof of concept). At the end of phase 2 (EOP2), a decision to initiate phase 3 studies is made that involves the commitment of considerable resources. One of the key factors in this decision is the expected efficacy and the associated predicted probability of success (PoS) in phase 3. Making a decision based upon the PoS requires decision makers to select a benchmark (or PoS criterion) for the PoS which if achieved would enable a “go-to-phase 3” decision. However, appropriately choosing the criterion requires knowledge of the operating characteristics associated with the decision criteria. A key operating characteristic that a funder/sponsor requires to make such a choice is to understand the predicted conditional probability of making a go-decision and subsequently failing in phase 3. In this article we show how such risks can be informed through the use of clinical trial simulation. We also highlight through a worked example in pancreatic cancer how this simulation exercise can help to decide between different development strategies for a specific indication.
Social cohesion, social capital and social exclusion: A cross cultural comparison
Creators: name: Hulse, Kathleen
name: Stone, Wendy
Publisher: name: Swinburne
Year: 2024

description: Interest in the concept of social cohesion has waxed and waned since Durkheim's foundation studies at the end of the 19th century, with the greatest interest being in times of fundamental economic, social and political change. The term is used in at least two different ways: firstly, in a policy context, to indicate the aims of, and rationale for, certain public policy actions; and secondly, as an analytical construct to explain social, political and sometimes economic changes. This article focuses on the first of these and traces the recent usage of social cohesion, spanning its take-up and influence within the Canadian policy environment, through to its usage (or otherwise) across liberal welfare regimes such as the UK, the US, Australia and New Zealand, and contrasting these experiences with its application in European institutions. The differential usage across these geopolitical settings is highlighted. Drawing upon Esping-Andersen's welfare state typology, and an explicit acknowledgement of national differences in relation to ethnic and cultural diversity, various explanations for these differences are discussed and their policy consequences explored.
Active three-dimensional photonic crystals with high third-order nonlinearity in telecommunication
Creators: name: Jia, Baohua
name: Buso, Dario
name: Li, Jiafang
name: Gu, Min
Publisher: name: Swinburne
Year: 2024

description: We developed a novel nanocomposite consisting of an organic-inorganic hybrid polymer modified with near-infrared emitting core-shell quantum dots. The composite has both high third-order nonlinearity and a high quantum efficiency and is suitable for photonic crystal fabrication.