cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Influence of Dynamic Response Characteristics on Traumatic Brain Injury
Creators: name: Post, Andrew
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Traumatic brain injury
Biomechanics
Brain injury
Injury reconstruction
principal component analysis
Falls
Finite element modelling

description: Research into traumatic brain injury (TBI) mechanisms is essential for the development of methods to prevent its occurrence. One of the most common ways to incur a TBI is from falls, especially for the young and very old. The purpose of this thesis was to investigate how the acceleration loading curves influenced the occurrence of different types of TBI, namely: epidural hematoma, subdural hematoma, subarachnoid hemorrhage, and contusion. This investigation was conducted in three parts. The first study conducted reconstructions of 20 TBI cases with varying outcomes using MADYMO, Hybrid III, and finite element methodologies. This study provided a dataset of threshold values for each of the TBI injuries measured in parameters of strain and stress. The results of this study indicated that using a combined reconstructive approach produces results which are in keeping with the literature for TBI. The second study examined how the characteristics of the loading curves which were produced from each reconstruction influenced the outcome using a principal components analysis. It was found that the duration of the event accounted for much of the variance in the results, followed with the acceleration components. Different curve characteristics also accounted for differing amounts of variance in each of the lesion types. Study 3 examined how the dynamic response of the impact influenced where in the brain a subdural hematoma (SDH) could occur. It was found that the largest magnitudes of acceleration produced SDH in the parietal lobe, and the lowest in the occipital lobe. Overall this thesis examined the mechanism of injury for TBI using a large dataset with methodologies which complement each other’s limitations. As a result in depth information of the nature of TBI was attained and information provided which may be used to improve future protection and standard development.
Rage against the Machine: Vincenzo Agnetti’s Critique of Industrial Alienation
Creators: name: Moure Cecchini, Laura
Publisher: name: Università degli Studi di Milano
Year: 2012

description: This essay analyzes the work of the Milanese artist Vincenzo Agnetti (1926-1981), in particular his pieces La macchina drogata (1968) and NEG (1970). Like other Italian artists and intellectuals of the 1960s and 1970s, Agnetti was concerned about the alienation caused by industrial development and consumer society, manifested in carefully designed objects of everyday use. To counteract the automatism of perception and thought that he considered the sign of alienated experience, Agnetti’s artworks employed several strategies that obliged the public to attend to its thinking processes. Thus, Agnetti put in practice forms of aesthetic estrangement similar to those evoked in the same period by Gillo Dorfles and Umberto Eco to counteract the widespread loss of awareness.
description: ENTHYMEMA, N° 7 (2012)
Study of Electrical Conductivity of Epoxy/Graphene Platelet Nanocomposites
Creators: name: Yu, Shuaibo
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Graphene
Nanocomposite
Electrical conductivity

description: Polymer nanocomposites are prepared by appropriately dispersing nanoscale fillers into polymer matrices. Graphene, a two-dimensional nano-carbon material with outstanding physical properties, has been widely studied as a conductive filler for nanocomposites. In this work, a gum Arabic aqueous solution was proposed as a new media to exfoliate graphite into few-layer graphene by liquid-phase sonication. Successful exfoliation was confirmed by Raman spectroscopy, scanning electron microscopy and transmission electron microscopy. Four types of graphene nanoplatelets were used to study the effects of the filler's aspect ratio. The one with the largest aspect ratio showed the best performance, where the conductivity of neat epoxy was increased by five orders of magnitude at 10 wt.%. Using a hot sonication technique and adding a small amount of second fillers further improved the electrical conductivities. The highest conductivity obtained in this study was 0.025 S/cm, which met the requirements of electromagnetic shielding material.
Silent Majority, Violent Majority: The Counter-Revolution in 70s Cinema
Creators: name: Novick, Peter Andrew
Publisher: name: Università degli Studi di Milano
Year: 2012

description: «There is one question, Inspector Callahan: Why do they call you ‘Dirty Harry’?» Harry, it is explained, «…Hates everybody: Limeys, Micks, Hebes, Fat Degos, Niggers, Honkies, Chinks…especially Spics». Don Siegel’s Dirty Harry (1971), famously labeled «fascist» by prominent film critic Pauline Kael, nonetheless represented something new and unique—the “Silent Majority’s” entry into liberal New Hollywood, a veritable counter-reformation to the new social movements having sprung up in the late Sixties and early Seventies. Far from the traditional American Right, however, and distinctly un-Fascist (in as much as the term means more than a simple epithet), these films acted to unite traditional European philosophy and revolutionary thought with organic conservative American tendencies, resulting in hybrid films which challenged the new social movements, while working within the medium of liberal New American Cinema. The article will address three themes from the era: violence and race in the city, revenge against “liberated women”, and fear and loathing of homosexuality. In each instance, using primary evidence from films and critical reviews from the Seventies and the present era, in addition to American and European theorists, the article will show how the counter-revolution in Seventies cinema failed to expunge the “revolutionary spirit” of the era. Rather, the Silent Majority’s visions of visual violence and reactionary values became part and parcel of the new liberated culture of the “Me Decade,” forever bounding the conservative celluloid revolt to the new cinematic culture.
description: ENTHYMEMA, N° 7 (2012)
Deformations of modified $r$-matrices and cohomologies of related algebraic structures
Creators: name: Jiang, Jun
name: Sheng, Yunhe
Publisher: name: arXiv
Year: 2022
Subjects: subject: Mathematical Physics (math-ph)
subject: Rings and Algebras (math.RA)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: Modified $r$-matrices are solutions of the modified classical Yang-Baxter equation, introduced by Semenov-Tian-Shansky, and play important roles in mathematical physics. In this paper, first we introduce a cohomology theory for modified $r$-matrices. Then we study three kinds of deformations of modified $r$-matrices using the established cohomology theory, including algebraic deformations, geometric deformations and linear deformations. We give the differential graded Lie algebra that governs algebraic deformations of modified $r$-matrices. For geometric deformations, we prove the rigidity theorem and study when is a neighborhood of a modified $r$-matrix smooth in the space of all modified $r$-matrix structures. In the study of trivial linear deformations, we introduce the notion of a Nijenhuis element for a modified $r$-matrix. Finally, applications are given to study deformations of complement of the diagonal Lie algebra and compatible Poisson structures.
description: 18 pages, to appear in JNCG
Evidence-Based Strategies for the Treatment of Peritoneal Malignancies during Health Care Resource Restriction: The COVID-19 Pandemic
Creators: name: Shariff, Farhana
name: Bischof, Danielle
name: Govindarajan, Anand
name: Prince, Rebecca
name: Burkes, Ronald
name: Haase, Erika
name: Mack, Lloyd
name: Temple, Walley
name: Hebbard, Pamela
name: Boulanger-Gobeil, Cindy
name: Giacomantonio, Carman
name: Brind’Amour, Alexandre
name: Sidéris, Lucas
name: Dubé, Pierre
name: Hamilton, Trevor
name: MacNeill, Andrea
name: Bouchard-Fortier, Antoine
name: Younan, Rami
name: McCart, Andrea
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2021

description: Background: The COVID-19 pandemic has put enormous pressure on hospital resources, and has affected all aspects of patient care. As operative volumes decrease, cancer surgeries must be triaged and prioritized with careful thought and attention to ensure maximal benefit for the maximum number of patients. Peritoneal malignancies present a unique challenge, as surgical management can be resource intensive, but patients have limited non-surgical treatment options. This review summarizes current data on outcomes and resource utilization to help inform decision-making and case prioritization in times of constrained health care resources. Methods: A rapid literature review was performed, examining surgical and non-surgical outcomes data for peritoneal malignancies. Narrative data synthesis was cross-referenced with relevant societal guidelines. Peritoneal malignancy surgeons and medical oncologists reviewed recommendations to establish a national perspective on case triage and mitigating treatment strategies. Results and Conclusions: Triage of peritoneal malignancies during this time of restricted health care resource is nuanced and requires multidisciplinary discussion with consideration of individual patient factors. Prioritization should be given to patients where delay may compromise resectability of disease, and where alternative treatment options are lacking. Mitigating strategies such as systemic chemotherapy and/or surgical deferral may be utilized with close surveillance for disease stability or progression, which may affect surgical urgency. Unique hospital capacity, and ability to manage the complex post-operative course for these patients must also be considered to ensure patient and system needs are aligned.
Additional file 2 of On the dynamical aspects of local translation at the activated synapse
Creators: name: Khlebodarova, Tamara M.
name: Kogai, Vladislav V.
name: Likhoshvai, Vitaly A.
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: Additional file 2: Figure S2. Dynamic regimes of system (1) depending on the rates of signal-dependent FMRP phosphorylation (kb) and FMRP-dependent synthesis of receptor proteins and their incorporation into the membrane (kx).
Measurement and Separation of Sterol Glycosides in Biodiesel and FAME
Creators: name: Montpetit, Alessandro
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Sterol glycosides
Biodiesel

description: The major issue that hinder the widespread use of biodiesel is its poor cold weather stability and operability. This is attributed minor components identified as monoglycerides (MG), diglycerides (DG) and sterol glycosides (SG). There is currently no standard method to determine SG levels in biodiesel. A method to isolate and measure SG concentration in biodiesel and FAME was first developed. This was accomplished by decompatibilizing SG from the biodiesel matrix using n-dodecane and purifying the solids using a Folch liquid-liquid extraction. The extracted SG was analyzed by GC-FID; the tricaprin internal standard was detected at 21.5 min and SG from 26-26 min. Recovery using this method was 100% ± 2.5% when 3 commercial canola biodiesel samples were spiked with 38 ppm SG and extracted. This method was used to measure SG concentration of filtered FAME produced using 0.3wt%, 0.5wt% and 0.7wt% at a MeOH:Oil (mol/mol) ratio of 4:1, 5:1, 6:1, 7:1 and 9:1. The biodiesel produced was characterized according to ASTM D6584; MG, DG and TG decreased with increasing catalyst concentration and MeOH:Oil ratios. The SG solubility in reactive FAME was found to be lowest at high glycerol catalyst concentration. High levels of TG were found to solubilize SG in the reactive FAME. Finally, the solubility of SG in reactive FAME increased when high ratios of methanol were used.
title: Representing Success? Postfeminist Gendered Religious Identities on Reality TV
Creators: name: Elzairy, Menatalla
Publisher: name: Arts
Year: 2025
Subjects: subject: Reality TV
subject: Gender
subject: Religion
subject: Judaism
subject: Islam
subject: The Church of Jesus Christ of Latter-day Saints
subject: Postfeminism
subject: Neoliberal Feminism
subject: Popular Feminism
subject: The Real Housewives
subject: My Unorthodox Life
subject: Critical Discourse Analysis
subject: Education--Religious
subject: Gender Studies
subject: Anthropology--Cultural
subject: Literature--American
subject: History--Middle Eastern
subject: American Studies
subject: Jewish Studies

description: This project examines the mediation of the relationship between female success and empowerment and the abandonment of religious identities across Netflix’s My Unorthodox Life, Bravo’s The Real Housewives of Salt Lake City and The Real Housewives of Dubai. Focusing on Julia Haart, Heather Gay and Sara Al Madani, I use critical discourse analysis to identify discursive themes that emerge from these women sharing their stories of overcoming gender inequality within their respective religious communities and their lives as successful businesswomen on reality TV. I explore how the themes identified serve to construct ideas about what an empowered and successful woman is in our contemporary neoliberal society and her relationship with religion. The analysis of the themes is guided by theorizations of postfeminism, neoliberal feminism and popular feminism. The themes identified are: (1) Entrepreneurial success as feminist empowerment; (2) Making over the religious subject; (3) Coming out moments and transformative motherhood; (4) Reclaiming the "good time girl"; and (5) Unveiling the feminine body. I argue that these shows are not simply showcasing the lives of these women as entertainment; rather, they actively construct a notion of female empowerment and success that is predicated on individual entrepreneurial success over collective feminist action. The shows also perpetuate the notion that women’s "empowerment” and embracing religious identities are mutually exclusive under neoliberalism. Finally, I also argue that these shows serve as how-to guides for becoming empowered entrepreneurial subjects unburdened by gender subordination and inequality.
Explicit model predictive control for active suspension systems with preview.
Creators: name: Theunissen, Johan
Publisher: name: University of Surrey
Year: 2020
Subjects: Active suspension; Regionless explicit model predictive control; Preview; Ride comfort

description: Latest advances in road profile sensors make the implementation of pre-emptive suspension control a viable option for production vehicles. From the control side, model predictive control (MPC) in combination with preview is a powerful solution for this application. However, the significant computational load associated with conventional implicit model predictive controllers (i-MPCs) is one of the limiting factors to the widespread industrial adoption of MPC. As an alternative, the authors of this study propose an explicit model predictive controller (e-MPC) for an active suspension system with preview. The MPC optimization problem is an mp-QP problem and is run offline. The online controller is reduced to a function evaluation. To overcome the increased memory requirements of e-MPC, the presented controller uses the recently developed regionless e-MPC approach. The controller was assessed through simulations and experiments on a sport utility vehicle (SUV) demonstrator with controllable hydraulic suspension actuators. For frequencies <4 Hz, the experimental results with the regionless e-MPC without preview show a ~10% reduction of the root mean square (RMS) value of the vertical acceleration of the sprung mass with respect to the same vehicle with a skyhook controller. The addition of preview improves the performance by a further 8% to 21% depending on the test.
Droits humains et mouvements sociaux en Amérique latine. Le cas des mouvements afro-colombiens
Creators: name: Moreno, Esperanza
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: appropriation des droits humains
significations des droits humains
mouvement social afro-colombien
"par le bas"

description: Cette recherche porte sur l’appropriation « par le bas » des droits humains par le mouvement social afro-colombien et sur les significations que ce dernier leur donne dans son discours et ses revendications. La recherche explore également les «luttes pour le sens » des termes clefs, entre le discours du mouvement et celui du gouvernement, au sujet des droits et des droits humains, à travers une analyse politique des périodes 1990-2014. À l’aide de la méthode de l’analyse du discours (École française) et, en s’appuyant principalement sur la théorie de l’articulation hégémonique de Laclau et Mouffe (2001), l’étude permet de montrer l’appropriation et la prise de parole légitime du discours des droits par le mouvement afro-colombien, sa contribution à la construction d’un discours des droits humains « issu d’en bas » ainsi qu’une volonté du mouvement et du gouvernement de contrôler le sens des certains termes clefs relatifs aux droits.
Digital Watermarking Based Image and Video Quality Evaluation
Creators: name: Wang, Sha
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Watermarking based image and video quality evaluation
adaptive watermarking
semi-fragile watermarking
DWT based watermark embedding
HVS masking

description: Image and video quality evaluation is very important. In applications involving signal transmission, the Reduced- or No-Reference quality metrics are generally more practical than the Full-Reference metrics. Digital watermarking based quality evaluation emerges as a potential Reduced- or No-Reference quality metric, which estimates signal quality by assessing the degradation of the embedded watermark. Since the watermark contains a small amount of information compared to the cover signal, performing accurate signal quality evaluation is a challenging task. Meanwhile, the watermarking process causes signal quality loss. To address these problems, in this thesis, a framework for image and video quality evaluation is proposed based on semi-fragile and adaptive watermarking. In this framework, adaptive watermark embedding strength is assigned by examining the signal quality degradation characteristics. The "Ideal Mapping Curve" is experimentally generated to relate watermark degradation to signal degradation so that the watermark degradation can be used to estimate the quality of distorted signals. With the proposed framework, a quantization based scheme is first implemented in DWT domain. In this scheme, the adaptive watermark embedding strengths are optimized by iteratively testing the image degradation characteristics under JPEG compression. This iterative process provides high accuracy for quality evaluation. However, it results in relatively high computational complexity. As an improvement, a tree structure based scheme is proposed to assign adaptive watermark embedding strengths by pre-estimating the signal degradation characteristics, which greatly improves the computational efficiency. The SPIHT tree structure and HVS masking are used to guide the watermark embedding, which greatly reduces the signal quality loss caused by watermark embedding. Experimental results show that the tree structure based scheme can evaluate image and video quality with high accuracy in terms of PSNR, wPSNR, JND, SSIM and VIF under JPEG compression, JPEG2000 compression, Gaussian low-pass filtering, Gaussian noise distortion, H.264 compression and packet loss related distortion.
The Copper and The Customer: an examination of police officers’ attitudes toward neighbourhood policing in a changing landscape
Creators: name: Fenn, Liam
Publisher: name: University of Surrey
Year: 2020

description: This thesis examines police officers’ attitudes toward neighbourhood policing and the customer-focused ethos it embodies. The support of police officers is essential to the effective delivery of neighbourhood policing. Whilst much has been written about the low status afforded to this style of policing within the occupational culture, more empirical evidence is needed to understand the ‘drivers’ of officers’ attitudes and how police managers might encourage support for such strategies. The research is informed by the voices, experiences and perspectives of officers serving in the Metropolitan Police Service (MPS). Using a mixed methods approach drawing on survey and interview data, the study assesses the cultural, organisational and wider contextual determinants of officers’ alignment to neighbourhood policing. In so doing, this study makes an important contribution to the existing literature, extending our knowledge about the barriers and conduits to the implementation of neighbourhood policing and the factors shaping the variations in officers’ cultural attitudes. Findings suggest that most MPS officers consider neighbourhood policing to be ‘real’ policing. Positive attitudes are strongly linked to officers’ organisational justice perceptions, attitudes toward serving the public and openness to their involvement. Senior ranking officers, women and those deployed in neighbourhood roles are highly supportive. Nevertheless, the results also expose that neighbourhood policing is often considered an inferior form of police work relative to other ‘specialisms’ and that rank-and-file officers do not always embrace the language of customer focus. It is argued that several organisational and contextual factors are undermining the positive sentiments most officers’ hold toward neighbourhood policing. This includes systems of performance measurement; specialisation opportunities; the composition of neighbourhood teams; training provision; role ambiguity; a perceived de-prioritisation of the neighbourhood function and declining organisational justice perceptions in the context of austerity. Ultimately, this has implications for officers’ commitment to their role and service provision.
Additional file 4 of On the dynamical aspects of local translation at the activated synapse
Creators: name: Khlebodarova, Tamara M.
name: Kogai, Vladislav V.
name: Likhoshvai, Vitaly A.
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: Additional file 4: Figure S4. Dynamic regimes of system (1) depending on the complexity and non-linearity of mTOR (hb) and the influence of the glutamate-specific signal on translation activation (Ka).
Differential Roles for the Retinoblastoma Protein in Cycling and Quiescent Neural Populations
Creators: name: Andrusiak, Matthew
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Brain Development
Cell Death
Cell Cycle
Rb/E2f Pathway

description: While the genetics of retinoblastoma and the implications of the retinoblastoma susceptibility gene, RB1, are well described, there is still scarce evidence to suggest why RB1 acts in such a cell-type specific manner. Using the murine cortex as a model, we examined the effects of RB1 deletion of cycling neural progenitors and post-mitotic neurons, in order to ascertain cell-type specific functions in the central nervous system. Using the previously identified cell-cycle independent role for Rb in tangential migration, we validated Rb/E2f regulation of neogenin and implicated it in this process. In quiescent cortical neurons, we identified a pivotal role for Rb in neuronal survival. Unlike in cycling progenitors, in post-mitotic neurons Rb specifically represses the expression of cell-cycle associated genes in an E2f-dependent manner. Finally, in cortical neurons in the absence of Rb, we observe an activation of chromatin at E2f associated promoters. To determine the role of direct interaction between Rb and chromatin modifying enzymes, we utilized an acute LXCXE-binding deficient mutant paradigm. We report that the LXCXE binding motif is dispensable in establishment and maintenance of cortical neuron quiescence and survival. The activation state of E2f-responsive promoters appears to be dependent on E2f-activity and not simply Rb-mediated repression. Taken as a whole, this thesis serves to support the hypothesis that Rb plays a diverse role in different cell-types by regulation of unique gene targets and regulatory mechanisms. Characterizing specific cancer-initiating populations and understanding the specific function of Rb will help in the treatment of many cancers resulting from RB1 mutation or mutation within the Rb/E2f pathway.
Period Integrals (Givental's I-function) of Calabi-Yau Hypersurface in $CP^{N-1}$ and Intersection Numbers of Moduli Space of Quasimaps from $CP^1$ with Two Marked Points to $CP^{N-1}$
Creators: name: Jinzenji, Masao
name: Matsuzaka, Kohki
Publisher: name: arXiv
Year: 2022
Subjects: subject: Algebraic Geometry (math.AG)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 14N35, 14J33, 32Q25

description: In this paper, we derive the generalized hypergeometric functions (period integrals) used in mirror computation of Calabi-Yau hypersurface in $CP^{N-1}$ as generating functions of intersection numbers of the moduli space of quasimaps from $CP^1$ with two marked points to $CP^{N-1}$.
description: 12 pages, Latex, minor errors are corrected
Authenticity : an experientialist aesthetic
Creators: name: Martin, Remy
Publisher: name: University of Surrey
Year: 2020

description: In this thesis I establish an experientialist, listener-focused account of authenticity in relation to recorded popular song. In response to limited musicological and phenomenological examination of listener authentication, I develop a synthesis of authenticity, self, and identity (as understood in ‘social’ theory, philosophy, psychology, and musicology) and embodied-ecological accounts of music perception and experience. Throughout, it is argued that authenticating experiences of ownership and agency arise within active, intentional, and imaginative encounters with music. Material is organised in four parts. In the opening sections of Part One I lay the intellectual foundations for an aesthetic of authenticity that has interrelated phenomenological, temporal, processual, and relational components. Following this, I establish a composite theoretical framework that draws together strands of ecological theory, embodied cognition and phenomenologically-oriented accounts of embodiment. In Part Two I posit authentication as grounded in bodily experience. After considering the phenomenological and musicological efficacy of Mark Johnson’s image schema theory and Maxine Sheets-Johnstone’s ‘archetypal corporeal-kinetic forms’, I examine affordances of motional entrainment, gestural recognition, affect, and temporal flow. Ecological correspondences between listener and song form the focus of Part Three, where, through the analysis of three case studies, I argue that authentication can emerge from the disclosure of ecologies – both real and imagined – that afford recognition, identification, and immersion. In Part Four I summarise my theoretic-analytical strategy, make a critical case for the phenomenological-hermeneutic treatment of listening experience, and, acknowledging authenticity’s ethical charge, probe more thoroughly the influence of musical experience (of self).
The Endocannabinoid Antagonist AM251 as a Method of Protection Prior to Global Cerebral Ischemia: Implications for Dopamine Function, Neuronal Survival and Behaviour
Creators: name: Dunbar, Megan
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Global Cerebral Ischemia
Stroke
Endocannabinoids
AM251
Dopamine
Excitotoxicity
Mesolimbic Circuit
Neuronal Survival
Behaviour

description: Implications for the endocannabinoid system in global cerebral ischemia has not been clearly defined. Ischemia produces an excitotoxic environment that is severely damaging to neurons, causing degradation of cell membrane and ultimately cell death. Contradicting research suggests both the benefits and adverse effects of endocannabinoids on neurological injury. Due to the excitotoxic nature of ischemic injury, and the mechanisms at play with endocannabinoid agonists, such as increased transmission of dopamine and glutamate, it is suspected that endocannabinoid antagonists, such as AM251, may a provide cell protection.40 male Wistar rats were separated into 4 groups (n=10/group). The first group of rats were administered AM251 (2 mg/kg, i.p) 30 minutes prior to global cerebral ischemia (four vessel occlusion), while the second group were given AM251, 30 minutes prior to sham surgery. Finally the last two groups were given a vehicle control instead of AM251 and given either ischemia or the sham surgery. Behavioural testing, open field test and elevated plus maze, took place after a five day recovery period following ischemia. Immunohistochemical analyses were performed using to mark tyrosine hydroxylase (TH) and dopamine receptor 1(DRD1) to compare dopamine function amongst groups. Cell survival was also evaluated using thionin staining. Ischemia induced significant reduction in dopamine within the mesolimbic circuit, including: ventral tegmental area, nucleus accumbens, CA3 & CA1 of the hippocampus, and basolateral amygdala. These reductions in dopamine transmission by global ischemia were partially or fully reversed when AM251 was given beforehand. Furthermore, cell survival was increased in the CA1 from treatment of AM251. Behavioural results show similar results that AM251 reversed emotional irregularities associated with ischemia insult. The endocannabinoid antagonist AM251 improves deficits in dopamine function, prevents cell death and regulates emotionality when given prior global cerebral ischemia.
Young People, Conflict & Criminality: Community Crime Prevention and its Legitimacy in Syria
Creators: name: Mouhiddin, Adnan
Publisher: name: University of Surrey
Year: 2022

description: Much of the existing literature on young people in conflict zones has concentrated on violence and peace building. Little, if any at all, has discussed their involvement in regular crime, how to prevent it and the preventive role of the community. It is well established that civil war societies experience a dramatic increase in crime rates during and after the war. Syria is no exception. With a rise in crime since the eruption of the civil war in 2012, the official statements of the Syrian government indicate that youth crime has quadrupled. Coinciding with international and humanitarian reports, these statements attribute such a rise to socio-economic factors. This not only threatens the wellbeing of the youth and their future opportunities, but also places the development and the future stability of the country at stake since their impact is likely to be evident during the coming decades. Therefore, there is a need today to start a conversation on a national level in Syria about youth offending and seek humane approaches by involving the Syrian community and this thesis aims to inform such a conversation.

description:

description: This thesis seeks to explore three crucial points. First, whether there has been or will be a rise in youth crime in Syria. Second, the thesis will provide an account of the factors that may have caused this rise. Third, in response to the collapse of the Syrian justice system and its inefficiency in dealing with the rising crime rates, the thesis will explore community crime prevention and what means suggest themselves as likely to be most effective based on existing literature and the original data of the thesis. This will lead to a discussion on the future desistence of young Syrians from offending and the legitimacy of community crime prevention, using civil society organisations and community police as case studies.

description:

description: The study draws on 30 semi-structured interviews with practitioners and 50 surveys questionnaires that were responded to by young Syrians between the age of 16 to 24. It engages with the opinion of both practitioners and respondents on key concepts and issues such as youth crime, community crime prevention and its legitimacy. The key findings suggest that youth crime has risen since the beginning of the war, and this is unlikely to change once a ceasefire is declared. The study also indicates that while community crime prevention among young offenders in Syria has a potential, its preventive role is subject to questions of its legitimacy and which community agencies are capable of assuming such a preventive role. The findings also challenge the concept of legitimacy that is based upon consensus, concluding that the legitimacy of community crime prevention in Syria draws from necessity rather than a mutual recognition between the state and the community.
Comparative Study of Colon Cancer Subclones Uncovers Potential Roles for AKAP7 and TP53RK in the Antiviral Response.
Creators: name: Davis, Colin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Oncolytic Virus
Antiviral
CT26
Clone
Heterogeneity
JAK-STAT
Viral Sensitivity

description: Tumour heterogeneity is a key hurdle for the effective treatment of cancer using oncolytic viruses (OVs). A better understanding of the pathways involved in delineating tumour cell resistance and hypersensitivity to OVs is critical in order to guide the development of new therapeutic strategies to enhance OVs. In this thesis, I performed a comparative genetic and epigenetic study of the murine OV-resistant colon cancer cell line CT26.WT and its hypersensitive subclone CT26.lacZ. This study led to the identification of retroviral insertion sites in AKAP7 and TP53RK genes, that are potentially involved in conveying sensitivity to infection by OVs and the dysregulation of the interferon antiviral response in the CT26.lacZ cell line. Gene overexpression and gene silencing experiments suggest a functional role of these proteins in controlling viral growth. Further investigation of these genes and their relationship to antiviral response pathways is warranted and may lead to novel strategies for improving the therapeutic activity of OVs.
title: There’s no place like home education
title: A narrative-based analysis of the personal experiences of work and employment of home educated people
titleType: Subtitle
Creators: name: Barrow, Rachael
Publisher: name: Lancaster University
Year: 2024
Subjects: Work
Employment
Employment relations
Home education, home schooling, policy implementation, England
home education
Employment experiences
Bourdieu

description: Little research exists on the personal experiences of home educated people
 in the workplace. This research aims to explore those personal experiences
 in various work and employment contexts, to develop an understanding of
 the role home education may have played in shaping these experiences. The
 study adopts a qualitative narrative-based methodology to capture a range
 of personal experiences and personal stories of work and employment. A
 Bourdieusian framework is used to develop a systematic understanding of
 these experiences, with the narrative accounts demonstrating the
 interrelatedness and significance of their home education for their
 subsequent experiences of work and employment. The study recounts varied
 individual personal experiences but also reveals some shared themes which
 include: The role of home education in shaping respondents’ sense of
 ‘self’, othering and judgement, the haunting quality of the home education
 experience, and the experience of the ‘game’ of work and employment. The
 study reveals how home educated people experience work and employment in a
 multitude of ways with some degree of similarity shared in these
 experiences that they attribute to their home education. It also reveals
 how home educated people do consider their personal experiences of home
 education to be significant to how they experience work and employment.
Additional file 1 of A novel approach for predicting protein S-glutathionylation
Creators: name: Anashkina, Anastasia A.
name: Poluektov, Yuri M.
name: Dmitriev, Vladimir A.
name: Kuznetsov, Eugene N.
name: Mitkevich, Vladimir A.
name: Makarov, Alexander A.
name: Petrushanko, Irina Yu.
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1.
title: Enhancing Time Series Predictions For Healthcare Decision Support Using Federated Learning and Large Language Models
Creators: name: Wei, Hanzhe
Publisher: name: Schulich School of Engineering
Year: 2025
Subjects: subject: Healthcare
subject: Artificial Intelligence

description: The integration of machine learning techniques into healthcare presents an exciting opportunity to enhance decision-making processes by effectively analyzing time series data to provide actionable insights. This thesis focuses on the role of federated learning as a mechanism to improve time series forecasting for blood demand, alongside leveraging large language models (LLMs) for time series anomaly detection. The challenge of maintaining data privacy is addressed while optimizing blood demand forecasting—a critical time series prediction task in healthcare logistics. A novel federated clustered autoregressive integrated moving average (ARIMA) method is developed to aggregate insights from multiple data sources without exposing sensitive information, ensuring data privacy while enhancing predictive accuracy and operational efficiency in blood supply management. The methodology is evaluated using synthetic datasets simulating various distribution scenarios and the MOVER (Medical Informatics Operating Room Vitals and Events Repository) dataset. In addition, the application of LLMs is explored for time series anomaly detection in healthcare, such as patient lab tests and vital signs. SPEAR (Soft Prompts Enhanced Anomaly Recognition) is introduced, a novel approach that leverages LLMs with soft prompts to improve efficiency and accuracy in detecting anomalies within time series data. Evaluated on datasets like MIMIC IV, NASA Satellite Telemetry, and Numenta Anomaly Benchmark, SPEAR outperforms baseline LLMs and state-of-the-art methods while maintaining memory efficiency. These advancements have important implications for healthcare: improved blood demand forecasting enables more efficient resource allocation and reduced waste, while enhanced anomaly detection can facilitate the identification of patient deterioration, potentially improving outcomes. This thesis contributes to the field by demonstrating how machine learning techniques—specifically federated learning and large language models—can optimize critical time series prediction tasks in healthcare, laying a foundation for intelligent, privacy-preserving, and context-aware systems that enhance decision-making processes in healthcare systems.
Additional file 1 of Effect and cost-effectiveness of national gastric cancer screening in Japan: a microsimulation modeling study
Creators: name: Hsi-Lan Huang
name: Leung, Chi Yan
name: Saito, Eiko
name: Katanoda, Kota
name: Hur, Chin
name: Kong, Chung Yin
name: Nomura, Shuhei
name: Shibuya, Kenji
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Additional file 1 : Table S1. Summary of selected data source for model parameterization. Table S2. Key model assumptions. Table S3. Net annual smoking cessation rate. Table S4. Natural history parameter for calibration and data sources. Table S5. CHEERS checklist—Items to include when reporting economic evaluations of health interventions. Figure S1. Prevalence of H. pylori infection in Japan by birth year from 1908 to 2003. Figure S2. Model predicted and observed gastric cancer incidence, both sexes. Figure S3. Model predicted and observed gastric cancer incidence, women. Figure S4. Model predicted and observed gastric cancer incidence, men. Figure S5. Model predicted and observed stage distribution of gastric cancer. Figure S6. Predicted gastric cancer mortality. Figure S7. Trends in gastric cancer incidence rates by age (ages 40–49 and ages 50–59) and sex, 1993 to 2014.
Interactive Voice Response Systems and Older Adults: Examination of the Cognitive Factors Related to Successful IVR Interaction and Proof-of-Principle of IVR Administration and Scoring of Neuropsychological Tests
Creators: name: Miller, Delyana Ivanova
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Interactive Voice Response systems
Cognitive factors
older adults
attitudes towards IVR

description: The main goal of this project was to enhance the use and usability of Interactive Voice Response Systems (IVR) for older people. The objective of study one was to examine older people’s perceptions of the technology and identify the most common difficulties experienced by older people when interactive with IVR using focus groups. Twenty-six people aged 65 and older took part in the study. Data were analyzed using frequency and chi square analyses. The results revealed negative attitudes towards the technology. Long menus, frustration about not being able to reach an operator and absence of shortcuts were some of the most common difficulties reported by participants. Study two examined the cognitive factors predicting successful IVR interaction in four commercially available IVR systems in a sample of 185 older adults. Linear regressions were performed on the data. Results indicated that working memory and auditory memory were the best predictors of successful IVR interaction. Using the same sample of participants as study two, study three examined older adults’ attitudes towards the four IVR systems in relation to their success in interacting with the technology. The study also evaluated the impact of gender on success and attitudes towards IVR. There was a significant positive correlation between success with IVR and favorable attitudes towards the technology. No gender differences emerged in both performance on IVR tasks and attitudes towards the technology. Study four evaluated the feasibility of using a voice-activated IVR to administer and score three short neuropsychological tests using a sub sample of the original sample of 185 older adults involved in study two and three. One hundred and fifty eight participants took part in the study. Results showed high correlations between the IVR and clinician scoring of the three tests. Nevertheless, a number of discrepancies and technical issues were discovered.
Steady State/Hopf Interactions in the Van Der Pol Oscillator with Delayed Feedback
Creators: name: Bramburger, Jason
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Dynamical Systems
Bifurcation Theory
Delay Differential Equations

description: In this thesis we consider the traditional Van der Pol Oscillator with a forcing dependent on a delay in feedback. The delay is taken to be a nonlinear function of both position and velocity which gives rise to many different types of bifurcations. In particular, we study the Zero-Hopf bifurcation that takes place at certain parameter values using methods of centre manifold reduction of DDEs and normal form theory. We present numerical simulations that have been accurately predicted by the phase portraits in the Zero-Hopf bifurcation to confirm our numerical results and provide a physical understanding of the oscillator with the delay in feedback.
title: A hybrid cloud framework for many-objective reservoir history matching utilizing classical and quantum Bayesian optimization
Creators: name: Samoil, Steven
Publisher: name: Schulich School of Engineering
Year: 2025
Subjects: subject: History Matching
subject: Quantum Computing
subject: Numerical Optimization
subject: Reservoir Engineering
subject: Engineering--Petroleum

description: Reservoir models for predicting subsurface fluid and rock behaviours are becoming increasingly large and can now include upwards of billions [94,46] (and potentially trillions) of grid cells and are pushing the limits of classical computational resources. History matching, where models are updated to match existing historical data more closely, is conducted to reduce the number of simulation runs and is one of the primary time-consuming tasks. As models get larger the number of parameters to match increases, and the number of objective functions increases, traditional classical methods start to reach their limitations. To address this we propose the use of Bayesian optimization in a hybrid cloud framework that can take advantage of both classical algorithms as well as quantum algorithms and hardware. Bayesian optimization iteratively searches for an optimal solution parameters through the refinement of a set of priors initialized with a set of simulation results. The hybrid cloud framework developed and investigated for this thesis work integrates various compute resources including standard workstations, computer clusters, and quantum computers. The early results using the hybrid cloud with the classical Bayesian optimization implementation were encouraging on tasks requiring over 100 objective functions and the simulated quantum Bayesian optimization results show performance that supports continued development towards integration with a real quantum computer. We propose integrating Bayesian optimization into the history matching workflow to efficiently iterate to find an optimal history match of production data.
Applying a Spatio-Temporal Approach to the Study of Urban Social Landscapes in Tianjin, China
Creators: name: Liu, Ziwei
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Urban Study
China

description: China’s economic reforms of 1978, which led to the country’s transition from a centrally-planned to a market-oriented economy, ushered in a phase of accelerated urbanization. Influenced by the economic transition and taking advantage of its privileged geographic and historic position, Tianjin has seen dramatic changes in its social landscape during the last three decades. Given this context, this study aims at understanding the different urban socio-spatial patterns of Tianjin and their mechanisms in three distinctive economic contexts by adapting both statistical and spatial approaches. Due to increasing population mobility caused by the economic reforms, the urban social landscape of Tianjin has become increasingly multifaceted, characterized by a “one axis, two nuclei” urban morphology. The rise of the Binhai New Area (TBNA) in the southeast is creating a dual-core urban social structure in Tianjin, with its traditional Urban Core located in the center of the city. In terms of the Urban Core’s expansion and population movements southeast toward the TBNA, an asymmetric suburbanization process is evident in Tianjin. Meanwhile, an additional population shift toward Beijing in the northwest is significant during 2000-2010, illustrating the changing relationship between these two neighbouring municipalities. By integrating itself with Beijing, Tianjin has not only recovered from under Beijing’s shadow during the centrally-planned economy period, but is also benefitting from Beijing in order to flourish.