cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
How social capital matters for receiving social support: on the complementary role of civil society in the COVID-19 pandemic
Creators: name: Höltmann, Gesine
name: Hutter, Swen
name: Specht, Jule
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: Social capital
subject: social support
subject: social trust
subject: civic engagement
subject: civil society
subject: coronavirus crisis
subject: COVID-19
subject: 300 Sozialwissenschaften::300 Sozialwissenschaften, Soziologie::300 Sozialwissenschaften

description: The Covid-19 pandemic has created a widespread need for social support. Similar to previous crises, we can observe activation in society to meet these needs: citizens have offered practical, emotional, and financial support, often within their social networks, but also to strangers and civil society organizations. In this paper, we examine the role of social capital in receiving social support during the Covid-19 pandemic in Germany using unique micro-level survey data. We investigate the importance of three aspects of social capital – the size of one’s support network, social trust, and organizational membership – for receiving (sufficient) social support. We focus on three types of support networks: family and friends, neighbors, and civil society actors. First, we find that while all three elements of social capital matter for receiving social support, a larger support network and organizational embeddedness matter primarily for receiving support beyond family and friendship networks. Second, civil society actors have been less likely to provide sufficient support in the pandemic, mainly acting in addition to strong ties and providing complementary support for individuals in particular need.
Supplementary document for High-efficiency, polarization-independent 1400 lines/mm retroreflective metagrating with cascaded nano-optical modes - 5959159.pdf
Creators: name: Qi, Hongguang
name: Xie, Lingyun
name: Zhu, Jingyuan
name: Wei, Zeyong
name: Jiao, Hongfei
name: SMIRNOV, YURY
name: Tikhonravov, Alexander
name: Cheng, Xinbin
name: Wang, Zhanshan
Publisher: name: Optica Publishing Group
Year: 2022
Subjects: Uncategorized

description: The details about simulations, analysis of merged-parameter fabrication tolerance, fabrication, the diffraction efficiency of fabricated metagrating.
Maskulinität im Zwiespalt: Die Identitätsentwicklung männlicher verhaltensabweichender Jugendlicher in geschlechtsspezifischen Unterbringungen
Creators: name: Zehnder, Edda Noa
Publisher: name: Hochschule Luzern – Soziale Arbeit
Year: 2024

description: Die vorliegende Arbeit widmet sich der Sensibilisierung und kritischen Auseinandersetzung
mit den Themen Geschlecht und der Unterbringung verhaltensabweichender männlicher Jugendlicher.
Im Folgenden wird der aktuelle Stand der Kinder- und Jugendhilfe untersucht.
Dabei wird ein Mangel an Daten zur Begründung der geschlechtsspezifischen Langzeitunterbringung
festgestellt. Jugendliche in der Adoleszenz, die sich in einer Phase der Identitätsentwicklung
befinden, sehen sich mit einer Reihe von Herausforderungen konfrontiert, da auf verhaltensabweichende
männliche Jugendliche oft mit Stigmatisierung reagiert wird. In diesem
Kontext wird betont, dass das Geschlecht in unserer Gesellschaft nicht nur als biologisches
Merkmal existiert, sondern auch durch unser Verhalten zum Ausdruck kommt. Es wird empfohlen,
dass Fachkräfte der Sozialpädagogik sowohl auf organisatorischer als auch auf individueller
Ebene eine bewusste Positionierung einnehmen und regelmässig ihre Arbeitsweisen
reflektieren sollten. Dies impliziert eine Betrachtung von Geschlecht als soziales Konstrukt und
nicht nur als biologisches Attribut sowie eine kritische Selbstreflexion als Teil des Systems.
Die vorliegende Arbeit verfolgt das Ziel, durch die Förderung eines kritischen und reflexiven
Ansatzes in der Sozialpädagogik einen Beitrag zur Schaffung einer inklusiveren und gerechteren
Praxis zu leisten. Diese Praxis soll es allen Jugendlichen, unabhängig von ihrem Geschlecht,
ermöglichen, die Unterstützung und Anerkennung zu erfahren, die sie benötigen,
um sich frei und authentisch entfalten zu können.
description: + Code Diss LU: hslusa basp + Fussnote: Bachelor-Arbeit, Hochschule Luzern – Soziale Arbeit, Studienrichtung Sozialpädagogik, 2024 + NL-Code: NLLUHSA202409
Phase diagram of CeRuPO under pressure investigated by $^{31}$P-NMR - Comparison between CeRuPO under pressure and the Ce(Ru$_{1-x}$Fe$_{x}$)PO system -
Creators: name: Kitagawa, Shunsaku
name: Kotegawa, Hisashi
name: Tou, Hideki
name: Yamauchi, Ryota
name: Matsuoka, Eiichi
name: Sugawara, Hitoshi
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We have performed $^{31}$P-NMR measurements on single-crystalline CeRuPO under pressure in order to understand the variation in magnetic character against pressure. The NMR spectra for $H \perp c$ and $H \parallel c$ at 2.15GPa split below the ordered temperature, which is a microscopic evidence of the change in the magnetic ground state from the ferromagnetic (FM) state at ambient pressure to the antiferromagnetic (AFM) state under pressure. The analysis of NMR spectra suggests that the magnetic structure in AFM state is the stripe-type AFM state with the AFM moment $m_{\rm AFM} \perp c$-axis and changes by magnetic field perpendicular to $c$-axis. In addition, the dimensionality of magnetic correlations in the spin and the $k$ space is estimated. We reveal that three-dimensional magnetic correlations in CeRuPO are robust against pressure, which is quite different from the suppression of the magnetic correlations along the $c$-axis by Fe substitution in Ce(Ru$_{1-x}$Fe$_{x}$)PO.
description: 7 pages, 6 figures, accepted for publication in Phys. Rev. B
Encapsulation of bone marrow-MSCs in PRP-derived fibrin microbeads and preliminary evaluation in a volumetric muscle loss injury rat model: modular muscle tissue engineering
Creators: name: Lalegül-Ülker, Özge
name: Şeker, Şükran
name: Elçin, Ayşe Eser
name: Elçin, Yaşar Murat
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology

description: Repair of volumetric muscle loss (VML) injuries is a complicated endeavour which necessitates the collaborative use of different regenerative approaches and technologies. Herein is proposed the development of fibrin-based microbeads (FMs) alone or as a bone marrow mesenchymal stem cell (MSC) encapsulation matrix for modular muscle engineering. FMs were generated through the ionotropic gelation of alginate and fibrinogen obtained from the platelet-rich plasma of whole blood, and then removing the alginate by citrate treatment. FMs were first characterized by FT-IR, SEM and water uptake tests. Then, the stability of FMs and the mitochondrial dehydrogenase activity of the MSCs encapsulated in FMs were evaluated under in vitro culture conditions. Eventually, the regenerative capacity of the cell-devoid and MSCs-encapsulated FMs was evaluated in a rat VML injury model involving 8 × 4×4 mm3-size bilateral defects in the biceps femoris muscles. The histochemical, immunohistochemical and semi-quantitative histomorphological scoring results retrieved at 30, 60 and 180 days demonstrated that the cell-devoid FMs supported muscle regeneration to a great extent. Moreover, MSCs-encapsulated FMs were more effective in shortening the regeneration period of the injured tissue of the rat VML, resulting in good myofibre orientation, while the Sham group resulted in incomplete repair with fibrotic scar tissue formations.
title: Whitepaper zum Projekt „BloG³ - Blockchainbasiertes Gesundheitsdatenmanagement für gesamtheitliche Gesundheitsprofile“
title: Delphi-Analyse: Szenarien und Geschäftsmodelle
titleType: Subtitle
Creators: name: Danelski, Alexa
name: Gersch, Martin
name: Erler, Christina
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: Gesundheitsdatenmanagementsystem
subject: Delphi-Verfahren
subject: Onkologie
subject: Gesundheitswesen
subject: digitale Transformation
subject: 300 Sozialwissenschaften::330 Wirtschaft::330 Wirtschaft

description: Aufbauend auf im Rahmen eines Delphi-Verfahrens erhobenen Daten und Erkenntnissen werden ökonomische Verwertungs- und Geschäftsmodelloptionen für ein Blockchain-basiertes Gesundheitsdatenmanagement- und Zugriff-/Rechteverwaltungssystem zur Einbettung in den ersten deutschen Gesundheitsmarkt diskutiert und reflektiert. Im Fokus steht hierbei die im Rahmen eines BMBF-geförderten Verbundprojekts entwickelte und im Entlassmanagement für onkologische Patientinnen prototypisch umgesetzte BloG³-Lösung. Eine reibungslose sektorenübergreifende, interdisziplinäre Versorgung im Behandlungsprozess von Onkologie-Patientinnen ist als Anwendungsfall von besonderer Relevanz, da hier zahlreiche sowohl stationäre als auch ambulante Versorgungsanbieter eingebunden sind und es hier bei der Überleitung oft noch zu Versorgungs-, Medien- und Informationsbrüchen kommt. In dem Diskussionsbeitrag beschreiben und analysieren wir sowohl den aktuellen und zukünftig zu erwartenden Stand der digitalen Transformation des Gesundheitswesens, als auch die Besonderheiten des deutschen Gesundheitswesens mit Fokus auf die Möglichkeiten für digitale Innovationen profitabel in den regulierten ersten Gesundheitsmarkt in Form von erstattungsfähigen Gesundheitsleistungen zu gelangen. Unter Berücksichtigung der aktuellen und absehbaren zukünftigen Rahmenbedingungen werden mithilfe der Expertinnenmeinungen aus dem Delphi-Verfahren mögliche Szenarien für die Verwertung der BloG³-Lösung für verschiedene Zeithorizonte (kurz-, mittel-, langfristig) reflektiert und diskutiert.
“Functional MRI Study of Human Gustatory Cortex: Technological Advancements and Applications to Basic and Clinical Neurosciences”
Creators: name: Canna, Antonietta
Publisher: name: Universita degli studi di Salerno
Year: 2019
Subjects: subject: ING-INF/06 BIOINGEGNERIA ELETTRONICA E INFORMATICA
subject: Functional mri
subject: Gustatory

description: 2017 - 2018
description: The purpose of brain plasticity is generating adaptive behaviours while predicting, interpreting, and responding to more and more complex tasks. Some of the most riveting questions in neuroscience revolve around the relationship between neural circuit structure, neural dynamics, and complex behaviour. The capability to understand the mechanisms that govern the brain under certain conditions is extremely helpful to predict human behaviour and to find possible brain alterations caused by or determining specific pathologies. … [edited by Author]
title: Sacroiliitis Prevalence on Magnetic Resonance Imaging of Crohn's Disease
Creators: name: Ilic, Dalibor
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Abdomen
subject: Small bowel
subject: Musculoskeletal joint
subject: Imaging sequences
subject: Inflammation
subject: MR-Colonography

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Magnetic resonance imaging (MRI) enterography is increasingly used to assess disease activity and complications in Crohns disease.The aim of this study is to assess the prevalence of acute sacroiliitis (SI) on MRI enterography performed on patients...
Polymerization-sensitive switch-on monomer for terminal transferase activity assay
Creators: name: Batule, Bhagwan S.
name: Lee, Chang Yeol
name: Park, Ki Soo
name: Park, Hyun Gyu
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: 60506 Virology
subject: Computational Biology

description: We herein describe a simple but efficient method for the determination of terminal transferase (TdT) activity, which relies on our finding that Fe(III)-quenched boron-dipyrromethene (BODIPY)-ATP is utilized as a switch-on monomer for polymerization and enables the facile synthesis of fluorescence oligonucleotides without additional, post-processing steps. As TdT carries out the synthesis of DNA by adding the monomers into growing chains, Fe(III) is displaced from BODIPY with the release of pyrophosphate group, which consequently leads to the generation of highly fluorescent long oligonucleotides. With this strategy, we selectively detected the TdT activity with high sensitivity. In addition, its practical applicability was successfully demonstrated by determining TdT activities in human serum.
title: Digitale Autor:innenschaft
title: Praktiken und Politiken schriftstellerischer Selbstinszenierung
titleType: Subtitle
Creators: name: Wolff, Paul
name: Ortlieb, Cornelia
name: Schaffrick, Matthias
name: Fassio, Marcella
name: Becker, Jenifer
name: Span, Madeleine
name: Kreuzmair, Elias
name: Hintze, Lena
name: Lüder, Sven
name: Walter-Jochum, Robert
name: Berning, Matthias
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: Autorschaft
subject: Social Media
subject: Digitale Literatur
subject: Öffentlichkeit
subject: Selbstinszenierung
subject: Performanz
subject: Medien
subject: Literaturwissenschaft
subject: 800 Literatur::800 Literatur, Rhetorik, Literaturwissenschaft::801 Literaturtheorie

description: Im digitalen Zeitalter rücken Autor:innen auf neue Weise in den Fokus der literarischen Öffentlichkeit: Wollen sie erfolgreich sein, müssen sie auch (sich selbst) performen. Die Beiträger:innen fragen nach den Funktionen und Erscheinungsformen auktorialer Performanz in Weblogs, sozialen Medien und auf anderen digitalen Bühnen, die im Zuge der Covid-19-Pandemie einen Boom erlebten. Sie zeigen, wie analoge Medien und Praktiken der Autor:inneninszenierung im Digitalen aufgegriffen, modifiziert und mitunter durch neue Modelle öffentlicher Autor:innenschaft ersetzt werden. Neben den ökonomischen Zusammenhängen interessiert dabei insbesondere die politische Dimension schriftstellerischer Selbstinszenierung, die in digitalen Öffentlichkeiten virulent wird.
title: Automating the Calculation of Clinical Outcomes with Multimedia Structured Reporting to Satisfy Pay-For-Performance Requirements
Creators: name: Vining, David
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Education and training
subject: Economics
subject: Structured reporting
subject: Computer Applications-General
subject: RIS
subject: PACS
subject: Management
subject: eHealth
subject: Computer applications

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Medical reimbursements in the United States are transitioning from fee-for-service to pay-for-performance. The Physician Quality Reimbursement System (PQRS) requires that physicians report quality metrics to data registries to prevent negative...
Competitive Agility: Is your business working in sync?
Creators: name: Theodoridis, Yiannos
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 350709
subject: Organisation and management theory

description: This presentation was presented at the Lean Productivity and Continuous Improvement Summit as part of the National Manufacturing & Supply Chain Conference which took place in Dublin Ireland on 29-30th of January 2020.https://web.archive.org/web/20200926104614/http://www.manufacturingevent.com/agendax/main-lean.pdfEnterprise Agility is a source of competitive advantage. To achieve this a company needs to be fully in sync from the values it has to its business model, operating model, and architecture.The presentation contains results from research that was performed by Accenture Strategy.
Indización de documentos LILACS 2022: calificadores revisón general
Creators: name: BIREME/OPS/OMS
Publisher: name: Zenodo
Year: 2022
Subjects: Indizacion de documentos
Metodologia LILACS
Cualificadores

description: V -Sesión Virtual sobre Indización de documentos según la Metodología LILACS (2022) Fecha: 28 julio 2022 Apertura: Suga, Sueli Mitiko Yano Ponente: Maria Graciela Sevila Ana Lucia Vidilli y Maria Anália Conceição Grabación: https://youtu.be/5Pwd8laFfpc Visite la página con toda la información:bit.ly/indizacionLILACS2022
description: {"references": ["https://lilacs.bvsalud.org/es/sesiones-virtuales-lilacs/indizacion-de-documentos-segun-la-metodologia-lilacs-2022/"]}
Competitive Agility: Is your business working in sync?
Creators: name: Theodoridis, Yiannos
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 350709
subject: Organisation and management theory

description: This presentation was presented at the Lean Productivity and Continuous Improvement Summit as part of the National Manufacturing & Supply Chain Conference which took place in Dublin Ireland on 29-30th of January 2020.https://web.archive.org/web/20200926104614/http://www.manufacturingevent.com/agendax/main-lean.pdfEnterprise Agility is a source of competitive advantage. To achieve this a company needs to be fully in sync from the values it has to its business model, operating model, and architecture.
Nanometer-scale Tomographic Reconstruction of 3D Electrostatic Potentials in GaAs/AlGaAs Core-Shell Nanowires
Creators: name: Lubk, A.
name: Wolf, D.
name: Prete, P.
name: Lovergine, N.
name: Niermann, T.
name: Sturm, S.
name: Lichte, H.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We report on the development of Electron Holographic Tomography towards a versatile potential measurement technique, overcoming several limitations, such as a limited tilt range, previously hampering a reproducible and accurate electrostatic potential reconstruction in three dimensions. Most notably, tomographic reconstruction is performed on optimally sampled polar grids taking into account symmetry and other spatial constraints of the nanostructure. Furthermore, holographic tilt series acquisition and alignment have been automated and adapted to three dimensions. We demonstrate 6 nm spatial and 0.2 V signal resolution by reconstructing various, previously hidden, potential details of a GaAs/AlGaAs core-shell nanowire. The improved tomographic reconstruction opens pathways towards the detection of minute potentials in nanostructures and an increase in speed and accuracy in related techniques such as X-ray tomography.
Experiences of patients with facioscapulohumeral dystrophy with facial weakness: a qualitative study
Creators: name: Sezer, Sümeyye
name: Cup, Edith H. C.
name: Roets-Merken, Lieve M.
name: Lanser, Anke
name: Siemann, Ietske
name: Weikamp, Janneke G.
name: Mul, Karlien
name: van Engelen, Baziel G.
name: Satink, Ton
name: Voermans, Nicol C.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: This study focuses on the functional and psychosocial consequences of facial weakness of patients with facioscapulohumeral muscular dystrophy (FSHD) and how they manage their daily lives. We conducted a qualitative study. Sixteen FSHD patients with varying degrees of facial weakness were interviewed using a semi-structured interview guide. Data were analyzed using the constant comparison approach based on the Straussian Grounded Theory. Reduced facial expression affected different aspects of a participant’s life, which is reinforced by fatigue. Particularly the younger participants described the confrontation with reduced facial expression as upsetting. The unpredictability of the progression of facial weakness makes many participants insecure and concerned. They generally tend to avoid discussing facial weakness with loved ones as well as with strangers. Patients would like the expert teams to shed more light on effective skill training and psychosocial support, especially for the younger patient group. A multidisciplinary approach is needed in addition to programs focusing on the individual aspects of facial weakness. As the experienced psychosocial effect is not commonly equal to the objective degree of facial weakness, we recommend a tailored approach. Finally, these programs should point out the importance of the patient’s own ingenuity.Implications for RehabilitationFacial weakness affects both activities and social participation in patients with facioscapulohumeral muscular dystrophy (FSHD), which is reinforced by fatigue.Many participants try to stay down to earth and focus on their ability to self-manage their obstacles regarding facial weakness.Thus, future treatment programs should have a multidisciplinary approach and should point out the importance of the patient’s own ingenuity. Facial weakness affects both activities and social participation in patients with facioscapulohumeral muscular dystrophy (FSHD), which is reinforced by fatigue. Many participants try to stay down to earth and focus on their ability to self-manage their obstacles regarding facial weakness. Thus, future treatment programs should have a multidisciplinary approach and should point out the importance of the patient’s own ingenuity.
On the structure of classical realizability models of ZF
Creators: name: Krivine, Jean-Louis
Publisher: name: arXiv
Year: 2014
Subjects: subject: Logic in Computer Science (cs.LO)
subject: Logic (math.LO)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics
subject: F.4.1
subject: 03E40

description: The technique of "classical realizability" is an extension of the method of "forcing"; it permits to extend the Curry-Howard correspondence between proofs and programs, to Zermelo-Fraenkel set theory and to build new models of ZF, called "realizability models". The structure of these models is, in general, much more complicated than that of the particular case of "forcing models". We show here that the class of constructible sets of any realizability model is an elementary extension of the constructibles of the ground model (a trivial fact in the case of forcing, since these classes are identical). It follows that Shoenfield absoluteness theorem applies to realizability models.
description: 17 pages
title: Ultrasound detection of deep venous thromboembolism
Creators: name: Nejadhamzeeigilani, Hamed
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Embolism / Thrombosis
subject: Health policy and practice
subject: Audit and standards
subject: Ultrasound
subject: Veins / Vena cava
subject: Haematologic

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: UK NICE guidelines on venothrombotic events (VTE) recommend all adults with a moderate-high risk of deep venous thrombosis (DVT), as defined by a Wells two-level DVT score and a raised d-dimer, to have a repeat ultrasound examination (USS) 6-8 days...
Fluorescence, turn-on detection of melamine based on its dual functions as fluorescence enhancer of DNA-AgNCs and Hg(II)-scavenger
Creators: name: Jeong, Sehan
name: Kwon, Woo Young
name: Hwang, Sung Hyun
name: Shin, Jiye
name: Kim, Yonghwan
name: Lee, Miran
name: Park, Ki Soo
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Computational Biology

description: A new method has been developed for the simple, fluorescence, turn-on detection of melamine, which utilizes DNA-templated silver nanoclusters (DNA-AgNCs) as a key component. In the sensor, melamine exhibits the dual functions: one is to enhance the fluorescence signal of DNA-AgNCs by its specific interaction with thymine residues in DNA template, and the other is to prevent Hg(II)-induced fluorescence quenching of DNA-AgNCs via its strong coordination with Hg(II). These consequently enable the sensitive and selective detection of melamine. By exploiting such novel features of melamine, we significantly increased the fluorescence response up to 360%, compared to the previous counterpart that relies on DNA-AgNCs only, and successfully determined melamine down to ca. 49 nM, a value that is 400 times lower than the safety level of 20 μM set by the US Food and Drug Administration. In addition, it was confirmed that the proposed approach works fine even in the real milk samples without any additional pre-treatment steps.
Cancer systems biology in the genome sequencing era: Part 2, evolutionary dynamics of tumor clonal networks and drug resistance
Creators: name: Wang, Edwin
name: Zou, Jinfeng
name: Zaman, Naif
name: Beitel, Lenore K.
name: Trifiro, Mark
name: Paliouras, Miltiadis
Publisher: name: arXiv
Year: 2014
Subjects: subject: Molecular Networks (q-bio.MN)
subject: FOS: Biological sciences

description: A tumor often consists of multiple cell subpopulations (clones). Current chemo-treatments often target one clone of a tumor. Although the drug kills that clone, other clones overtake it and the tumor reoccurs. Genome sequencing and computational analysis allows to computational dissection of clones from tumors, while singe-cell genome sequencing including RNA-Seq allows to profiling of these clones. This opens a new window for treating a tumor as a system in which clones are evolving. Future cancer systems biology studies should consider a tumor as an evolving system with multiple clones. Therefore, topics discussed in Part 2 of this review include evolutionary dynamics of clonal networks, early-warning signals for formation of fast-growing clones, dissecting tumor heterogeneity, and modeling of clone-clone-stroma interactions for drug resistance. The ultimate goal of the future systems biology analysis is to obtain a whole-system understanding of a tumor and therefore provides a more efficient and personalized management strategies for cancer patients.
description: 2 figs. Related papers can be found at http://www.cancer-systemsbiology.org, Seminar in Cancer Biology, 2013
title: Testicular MRI: Beyond malignancy
Creators: name: Bosch Barragan, Ferran
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Genital / Reproductive system male
subject: Abdomen
subject: MR
subject: Contrast agent-intravenous
subject: Neoplasia
subject: Inflammation
subject: Ischaemia / Infarction

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To review the current role of magnetic resonance imaging (MRI) in testicular lesions and its indications. To show the characteristic MRI findings for benign and malignant conditions involving the...
Physical activity correlates in children and adolescents with autism spectrum disorder: a systematic review
Creators: name: Arkesteyn, Anke
name: Van Damme, Tine
name: Thoen, Anoushka
name: Cornelissen, Véronique
name: Healy, Sean
name: Vancampfort, Davy
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: This systematic review examined correlates of physical activity (PA) at all levels of the socio-ecological model (i.e., intrapersonal, interpersonal, environmental and policy level) in children and adolescents with autism spectrum disorder (ASD). Major electronic databases were searched from inception until March 23rd, 2021. A summary coding was used to analyze the data for children (3–12 years) and adolescents (13–18 years) with ASD separately. Out of the 79 potential PA correlates, retrieved from 32 studies (991 657 children; 3857 adolescents), only five correlates were consistently examined as a PA correlate (i.e., examined in four or more studies) in children and adolescents with ASD. Only age was inversely associated with PA in children and adolescents with ASD. Data on gender, body mass index, autism severity level and day of the week being physically active in children with ASD were mixed. We only found consistent evidence for age being inversely related to PA. Our review indicates that more research is needed to explore intrapersonal, interpersonal, environmental and policy-related correlates of PA in children and adolescents with ASD.IMPLICATIONS FOR REHABILITATIONRehabilitation programs should take into account that in particular older children and adolescents with autism spectrum disorder are at risk for physical inactivity.Boys and girls with autism spectrum disorder need the same care when motivating them to be more physically active. Rehabilitation programs should take into account that in particular older children and adolescents with autism spectrum disorder are at risk for physical inactivity. Boys and girls with autism spectrum disorder need the same care when motivating them to be more physically active.
Effect of polymorphism on IL1A to cancer susceptibility: Evidence based on 34,016 subjects
Creators: name: Xia, Haoran
name: Chen, Yiding
name: Meng, Jialin
name: Liang, Chaozhao
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Cancer

description: IL-1α is closely related to the development and metastasis of cancer, and its polymorphisms have been reported affecting the susceptibility of malignancy tumors, yet the conclusions are controversial. Present an overall meta-analysis was performed to reach more general findings. Relevant literature was searched from Google Scholar, Web of Science, PubMed, EMBASE, CNKI database and Wanfang database, and the association among polymorphism and cancer risk was appraised by counting ORs and 95% CIs of overall and stratification analysis. The date from 15,586 cases and 18,430 controls in 40 publications were enrolled. There is significantly upregulated risk leads by rs3783553 in all genetic models, while the same tendency was found in all cancer types. The results also suggest a high risk of cancer susceptibility in patients carried rs1800587 polymorphism, of which draw out form allelic and homozygote models in overall studies, especially for cervical cancer. However, there are no significant results in analysis of rs17561. In a word, IL1A SNPs play an essential role in upregulating cancer susceptibility, and current analysis provides detail date for further study in the future.
Data-driven deep-learning methods for the accelerated simulation of Eulerian fluid dynamics
Creators: name: Lino Valencia, Mario
Publisher: name: Imperial College London
Year: 2023

description: Deep-learning (DL) methods for the fast inference of the temporal evolution of ﬂuid-dynamics systems, based on the previous recognition of features underlying large sets of ﬂuid-dynamics data, have been studied. Speciﬁcally, models based on convolution neural networks (CNNs) and graph neural networks (GNNs) were proposed and discussed. A U-Net, a popular fully-convolutional architecture, was trained to infer wave dynamics on liquid surfaces surrounded by walls, given as input the system state at previous time-points. A term for penalising the error of the spatial derivatives was added to the loss function, which resulted in a suppression of spurious oscillations and a more accurate location and length of the predicted wavefronts. This model proved to accurately generalise to complex wall geometries not seen during training. As opposed to the image data-structures processed by CNNs, graphs oﬀer higher freedom on how data is organised and processed. This motivated the use of graphs to represent the state of ﬂuid-dynamic systems discretised by unstructured sets of nodes, and GNNs to process such graphs. Graphs have enabled more accurate representations of curvilinear geometries and higher resolution placement exclusively in areas where physics is more challenging to resolve. Two novel GNN architectures were designed for ﬂuid-dynamics inference: the MuS-GNN, a multi-scale GNN, and the REMuS-GNN, a rotation-equivariant multi-scale GNN. Both architectures work by repeatedly passing messages from each node to its nearest nodes in the graph. Additionally, lower-resolutions graphs, with a reduced number of nodes, are deﬁned from the original graph, and messages are also passed from ﬁner to coarser graphs and vice-versa. The low-resolution graphs allowed for eﬃciently capturing physics encompassing a range of lengthscales. Advection and ﬂuid ﬂow, modelled by the incompressible Navier-Stokes equations, were the two types of problems used to assess the proposed GNNs. Whereas a single-scale GNN was suﬃcient to achieve high generalisation accuracy in advection simulations, ﬂow simulation highly beneﬁted from an increasing number of low-resolution graphs. The generalisation and long-term accuracy of these simulations were further improved by the REMuS-GNN architecture, which processes the system state independently of the orientation of the coordinate system thanks to a rotation-invariant representation and carefully designed components. To the best of the author’s knowledge, the REMuS-GNN architecture was the ﬁrst rotation-equivariant and multi-scale GNN. The simulations were accelerated between one (in a CPU) and three (in a GPU) orders of magnitude with respect to a CPU-based numerical solver. Additionally, the parallelisation of multi-scale GNNs resulted in a close-to-linear speedup with the number of CPU cores or GPUs.
Unwinding motion of a twisted active-region filament
Creators: name: Yan, X. L.
name: Xue, Z. K.
name: Liu, J. H.
name: Kong, D. F.
name: Xu, C. L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: To better understand the structures of active-region filaments and the eruption process, we study an active-region filament eruption in active region NOAA 11082 in detail on June 22, 2010. Before the filament eruption, the opposite unidirectional material flows appeared in succession along the spine of the filament. The rising of the filament triggered two B-class flares at the upper part of the filament. As the bright material was injected into the filament from the sites of the flares, the filament exhibited a rapid uplift accompanying the counterclockwise rotation of the filament body. From the expansion of the filament, we can see that the filament is consisted of twisted magnetic field lines. The total twist of the filament is at least 5$π$ obtained by using time slice method. According to the morphology change during the filament eruption, it is found that the active-region filament was a twisted flux rope and its unwinding motion was like a solar tornado. We also find that there was a continuous magnetic helicity injection before and during the filament eruption. It is confirmed that magnetic helicity can be transferred from the photosphere to the filament. Using the extrapolated potential fields, the average decay index of the background magnetic fields over the filament is 0.91. Consequently, these findings imply that the mechanism of solar filament eruption could be due to the kink instability and magnetic helicity accumulation.
description: 26 pages,11 figures, accepted for publication in ApJ
DNA Repair Mechanisms of Antarctic Marine Bacteria in Extreme Environments
Creators: name: Feltrin, Rayana dos Santos
name: Durham, Alan Mitchell
name: Rozas, Enrique
name: Nascimento, Claudio  Augusto Oller do
name: Oliveira, Renatta Santos de
name: Galhardo, Rodrigo da Silva
name: Menck, Carlos Frederico Martins
Publisher: name: Zenodo
Year: 2023
Subjects: Extreme Environments
Antarctica
DNA Repair

description: The Antarctic continent presents a myriad of extreme environmental conditions and a unique isolation from the impacts of human society. Organisms in this region face constant threats to their genetic material, with various agents capable of damaging the DNA molecule, including the potent ultraviolet radiation (UV) emanating from sunlight. Additionally, the harsh environmental factors, particularly the extremely low temperatures, further contribute to the challenge of maintaining DNA stability. As a result, Antarctica serves as a compelling setting for studying how organisms navigate the preservation of genome integrity in such harsh conditions. In this study, we aim to delve into the mechanisms employed by microorganisms to survive in the face of these extreme Antarctic environments. To achieve this, we have conducted genome sequencing of three Antarctic marine bacteria. Two of these bacteria were isolated from sediment samples at depths of 280 meters, while the third was retrieved from a depth of 1500 meters in the Bransfield Strait. Deeper sea conditions entail higher concentrations of CO2 under elevated atmospheric pressure, adding an additional layer of environmental challenge for these bacteria. The DNA extracted from these isolates was sequenced using the Illumina platform. Subsequently, we performed de novo genome assembly utilizing SPAdes v3.15.4, and assessed assembly metrics with QUAST v5.2.0. Genome completeness was evaluated using BUSCO v5.3.1. Furthermore, we conducted annotation via the Prokaryotic Genome Annotation Pipeline (PGAP) and identified the species based on the 16S ribosomal RNA (rRNA) sequence, employing the software GTDB-Tk 2.1.0. Additionally, we scrutinized the presence of DNA repair genes in these organisms using blastp, with hits meeting criteria of e-value < 1E-5, coverage > 60%, and identity > 30% considered as orthologs. Hits not meeting these criteria had their conserved protein domains analyzed on InterPro to capture potential false-negatives. Preliminary findings indicate that the majority of DNA repair genes are indeed present in these bacteria, suggesting a diverse array of strategies they employ to combat DNA damage. Notably, nucleotide excision repair emerged as the most conserved pathway in these bacteria. These results underscore the significance of repair pathways involved in the removal of sunlight-induced lesions, indicating their crucial role in maintaining genome integrity in an environment characterized by high levels of UV radiation.
title: Radiology preparedness for mass casualty incidents: a national survey, are you ready?
Creators: name: Ryan, James
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Emergency
subject: Trauma
subject: Professional issues
subject: CT
subject: Conventional radiography
subject: Ultrasound
subject: Education
subject: Education and training

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: A Mass Casualty Incident (MCI) is defined as an event that produces a large number ofcasualties in a short period of time whichtemporarily overwhelms the resources of local healthcare systems 1,2 . Natural disasters,accidents and terrorism can lead...
Polymerization-sensitive switch-on monomer for terminal transferase activity assay
Creators: name: Batule, Bhagwan S.
name: Yeol Lee, Chang
name: Soo Park, Ki
name: Park, Hyun Gyu
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: 60506 Virology
subject: Computational Biology

description: We herein describe a simple but efficient method for the determination of terminal transferase (TdT) activity, which relies on our finding that Fe(III)-quenched boron-dipyrromethene (BODIPY)-ATP is utilized as a switch-on monomer for polymerization and enables the facile synthesis of fluorescence oligonucleotides without additional, post-processing steps. As TdT carries out the synthesis of DNA by adding the monomers into growing chains, Fe(III) is displaced from BODIPY with the release of pyrophosphate group, which consequently leads to the generation of highly fluorescent long oligonucleotides. With this strategy, we selectively detected the TdT activity with high sensitivity. In addition, its practical applicability was successfully demonstrated by determining TdT activities in human serum.
Negative Feedback and Physical Limits of Genes
Creators: name: Zabet, Nicolae Radu
Publisher: name: arXiv
Year: 2014
Subjects: subject: Molecular Networks (q-bio.MN)
subject: FOS: Biological sciences

description: This paper compares the auto-repressed gene to a simple one (a gene without auto-regulation) in terms of response time and output noise under the assumption of fixed metabolic cost. The analysis shows that, in the case of non-vanishing leak expression rate, the negative feedback reduces both the switching on and switching off times of a gene. The noise of the auto-repressed gene will be lower than the one of the simple gene only for low leak expression rates. Summing up, for low, but non-vanishing leak expression rates, the auto-repressed gene is both faster and less noisier compared to the simple one.
description: 17 pages, 7 figures, 1 table
Free, Prior and Informed Consent: Getting political to improve impact
Creators: Kazemi, Leila
Mebratu-Tsegaye, Tehtena
Publisher: name: Columbia University
Year: 2020
Subjects: Free, prior, and informed consent (Indigenous rights)
Consent (Law)
Indigenous peoples--Civil rights
Indigenous peoples--Politics and government

description: Indigenous and tribal peoples’ right to free, prior and informed consent (FPIC) has transformative potential. Where this right is recognized and meaningfully operationalized, FPIC can help safeguard a variety of rights specific to indigenous and tribal peoples, and while doing so, remake the power relations between peoples, governments, and, in some contexts, extractives companies. Yet, this potential is far from being realized: there is a considerable gap between FPIC in theory and what happens in practice. Our research shows that the political contexts in which FPIC and prior consultation processes unfold account for much of this gap. Global actors who support broader recognition of FPIC and improved implementation of prior consultation processes usually focus on normative standards and best practices–and much less on directly addressing the political challenges and opportunities that shape how these processes unfold. This brief—drawing on the larger research project on which it is based—aims to spur practitioners to apply a more systematic political lens to their work on FPIC and prior consultation processes. It previews some of the key political challenges facing effective implementation, based on research from three countries in Latin America—Brazil, Colombia, and Peru—and proposes a menu of different approaches to tackle them. This brief is part of the Columbia Center on Sustainable Investment's PLUS Politics series, a multi-part series of briefs from CCSI that aims to encourage practitioners to apply a more systematic political lens to their work on governance in the extractive industries.
Synthesis of glycosylphosphatidylinositol analogues with an unnatural β-D-glucosamine-(1→6)-myo-inositol motif
Creators: name: Yan, Xin
name: Guo, Zhongwu
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Glycosylphosphatidylinositol (GPI) anchors contain a unique α-D-glucosamine-(1→6)-myo-inositol [αGlcN(1,6)Ins] motif in their conserved core structure. To facilitate investigations of the functional roles of this structural motif, two GPI analogues containing unnatural βGlcN(1,6)Ins, instead of αGlcN(1,6)Ins, and an alkyne group at different positions of the GPI core were designed and synthesized. To this end, an orthogonally protected pseudopentasaccharide derivative of GPIs with the βGlcN(1,6)Ins motif was convergently constructed via [3 + 2] glycosylation and used as the common intermediate to prepare both GPI analogues by streamlined synthetic protocols. The pseudopentasaccharide intermediate and developed protocols can be widely applicable to access various GPI analogues with the βGlcN(1,6)Ins motif. The target GPI analogues contain an alkyne, which allows their further modification to introduce various molecular labels via click chemistry, making them useful probes for the study of GPI anchorage. The differences in reactivity and NMR behavior of the two GPI analogues, as well as the differences of these analogues from previously reported GPI derivatives of similar structure containing an αGlcN(1,6)Ins motif, suggest that the 2-O-phosphoethanolamine moiety on mannose-I and the linkage form of GlcN in GPIs can have a decisive impact on the structure, which is likely relevant to biology.
Fluid description of multi-component solar partially ionized plasma
Creators: name: Khomenko, Elena
name: Collados, Manuel
name: Diaz, Antonio
name: Vitas, Nikola
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We derive self-consistent formalism for the description of multi-component partially ionized solar plasma, by means of the coupled equations for the charged and neutral components for an arbitrary number of chemical species, and the radiation field. All approximations and assumptions are carefully considered. Generalized Ohm's law is derived for the single-fluid and two-fluid formalism. Our approach is analytical with some order-of-magnitude support calculations. After general equations are developed we particularize to some frequently considered cases as for the interaction of matter and radiation.
description: accepted by Physics of Plasmas
Insight into gold-catalyzed glycosylation of glycosyl ynenoates
Creators: name: Zhang, Lvfeng
name: Liang, Youling
name: Li, Xiaona
name: Liu, Rongkun
name: Zheng, Jibin
name: Xu, Peng
name: Yu, Biao
name: Yang, You
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Chemical Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Gold-catalyzed glycosylation using alkyne donors is a versatile approach for the efficient assembly of diverse types of glycosides due to its catalytic and mild glycosylation properties. Minor structural alterations might significantly affect the glycosylation reaction when the alkyne-based leaving groups are simplified. By mapping the glycosylation reactivities of a series of structurally simplified alkyne donors, herein we demonstrate the role of each characteristic functional group of glycosyl ynenoates. Based on the isolation and the X-ray diffraction characterization of the pyran-5-ylgold(I) complex generated from the leaving group, a plausible mechanism of the gold(I)-catalyzed glycosylation with glycosyl ynenoates as donors was proposed.