Integrated genomic characterization of oesophageal carcinoma
Creators: name: Sun, Qiang
name: Kelsen, David P.
name: Wiznerowicz, MacIej
name: Lu, Yiling
name: Sandusky, George
name: Wan, Yunhu
name: Weinhold, Nils
name: Wong, Alexandra M.
name: Carvalho, Andre L.
name: Luketich, James D.
name: Sharp, Alexis
name: Bowlby, Reanne
name: Juhl, Hartmut
name: Wu, Ye
name: Sipahimalani, Payal
name: Naima, Zaid
name: Boussioutas, Alex
name: Penny, Robert
name: Shelton, Candace
name: Ramalingam, Suresh
name: Felau, Ina
name: Sica, Gabriel
name: Camargo, M. Constanza
name: Wong, Tina
name: Morris, Scott
name: Lee, Jae-Hyuck
name: Hutter, Carolyn M.
name: Cordes, Matthew G.
name: Carey, Frank
name: Chakravarty, Debyani
name: Huelsenbeck-DIll, Lori
name: Owonikoko, Taofeek
name: Zhangw, Jianhua
name: Frick, Jessica
name: Rathme, W. Kimryn
name: Wijnhoven, Bas
name: Sander, Chris
name: Jang, Hee-Jin
name: Kim, Jihun
name: Fronick, Catrina C.
name: Stepa, Serghei
name: Zhang, Julia
name: Noble, Michael S.
name: Robertson, A. Gordon
name: Fulton, Lucinda A.
name: Naresh, Rashi
name: Lander, Eric
name: Lehmann, Kjong-Van
name: Parfenov, Michael
name: Cibulskis, Carrie
name: McLellan, Michael D.
name: Ajani, Jaffer A.
name: Schein, Jacqueline E.
name: Zhang, Hailei
name: Shen, Hui
name: Sofia, Heidi J.
name: Saksena, Gordon
name: Zmuda, Erik
name: Abeshouse, Adam
name: Derks, Sarah
name: Wu, Hsin-Ta
name: Godwin, Andrew
name: Tang, Jiabin
name: Pennathur, Arjun
name: Setdikova, Galiya
name: Cho, Juok
name: Radenbaugh, Cruz Amie
name: Dunford, Andrew
name: Behera, Madhusmitara
name: Kucherlapati, Raju
name: Meyerson, Matthew
name: Ferguson, Martin L.
name: Murray, Bradley A.
name: Park, Peter J.
name: Den Berg, David J. Van
name: Piazuelo, M. Blanca
name: IanForgie, Dundee
name: Defrietas, Timothy
name: Pantazi, Angeliki
name: Gerken, Mark
name: Khuri, Fadio
name: Miller, Michael
name: Iacocca, Mary
name: Mayo, Michael
name: Cherniack, Andrew D.
name: Zhou, Zhongren
name: Lichtenberg, Tara M.
name: Mungall, Karen L.
name: Hinoue, Toshinori
name: Trevisan, Felipe Amstalden
name: Pihl, Todd
name: Thorsson, Vésteinn
name: Demchok, John A.
name: Weisenberger, Daniel J.
name: Bullman, Susan
name: Gastier-Foster, Julie M.
name: Eschbacher, Jennifer
name: Lin, Pei
name: Ladanyi, Marc
name: Yang, Liming
name: Chuah, Eric
name: Akbani, Rehan
name: Tarnuzzer, Roy
name: Frazer, Scott
name: Sohn, Bo Hwa
name: Cheong, Jae-Ho
name: Meier, Samuel R.
name: Beer, David G.
name: Kim, Jaegil
name: Madan, Rashna
name: Lai, Phillip H.
name: Potapova, Cureline Olga
name: Lee, Semin
name: Paulauskis, Joseph
name: Cibulskis, Kristian
name: Liu, Wenbin
name: Yang, Lixing
name: Bass, Adam J.
name: Demchok, John
name: Kim, Goyang Hark Kyun
name: Park, Do Young
name: Sheth, Margi
name: Holbrook, Andrea
name: Miller, Christopher A.
name: Kucherlap, Melanie
name: Saller, Charles
name: Matsushita, Marcus Medeiros
name: Knox, Jennifer
name: Noushmehr, Houtan
name: Garman, Katherine
name: Tang, Laura
name: Wise, Lisa
name: Getz, Gad
name: Hadjipanayis, Angela
name: Weinstein, John N.
name: Zhang, Jiashan
name: Sánchez-Vega, Francisco
name: Leraas, Kristen
name: Shelton, Troy
name: Seth, Sahil
name: Zhang, Hongxin
name: Odze, Robert D.
name: Dos Santos, Jose Sebastiaõ
name: Carlsen, Rebecca
name: McCall, Shannon J.
name: Bernard, Brady
name: Shih, Juliann
name: Bootwalla, Moiz S.
name: Jones, Steven J. M.
name: Mallery, David
name: Bristow, Christopher A.
name: Liu, Ouida
name: El-Zimaity, Haila
name: Schmidt, Heather K.
name: Ma, Yussanne
name: Chetty, Runjan
name: Reilly, Colleen
name: Rabkin, Charles S.
name: Wang, Zhining
name: Laird, Peter W.
name: Marra, Marco A.
name: Thiessen, Nina
name: Tam, Angela
name: Pickens, Allan
name: Shmulevich, Ilya
name: Heiman, David I.
name: Zhang, Wei
name: Bartlett, John
name: Parfitt, Jeremy
name: Schultz, Nikolaus
name: Gao, Jianjiong
name: Kwon, Sun Young
name: Hegde, Apruva
name: Gulley, Margaret L.
name: Curtis, Christina
name: Janjigian, Yelena
name: Bowen, Jay
name: Zornig, Hamburg Carsten
name: Zenklusen, Jean Claude
name: DIng, Li
name: Dhir, Rajiv
name: Voet, Doug
name: Raphael, 
name: Ferrer-Torres, Daysha
name: Raphae, Benjamin J.
name: Iype, Lisa
name: Park, Young Soo
name: Protopopov, Alexei
name: Mungall, Andrew J.
name: Fulidou, Victoria
name: Polak, Paz
name: De Oliveira, Antonio Talvane
name: Schneider, Barbara G.
name: Le, Xuan
name: Lawrence, Michael
name: Vinco, Michele
name: Mills, Gordon B.
name: Tarvin, Katherine
name: Kemp, Rafael
name: Carlotti, Carlos Gilberto
name: Reynolds, Sheila M.
name: Lawrence, Michael S.
name: Leraas, Kristen M.
name: Taylor-Weiner, Amaro
name: Da Cunha Tirapelli, Daniela Pretti
name: Mahadeshwar, Harshad S.
name: Wilson, Richard K.
name: Fulton, Robert S.
name: Bennett, Joseph
name: Shen, Ronglai
name: Crain, Daniel
name: Kasaian, Katayoon
name: McLellan, Michael
name: Liu, Jai
name: Ally, Adrian
name: Saggioro, Fabiano Pinto
name: Curley, Erin
name: Mardis, Elaine R.
name: Reid, Brian J.
name: Song, Xingzhi
name: Brooks, Denise
name: Ramirez, Nilsa C.
name: MillsShaw, Kenna R.
name: Appelbaum, Elizabeth L.
name: Kundra, Ritika
name: Mozgovoy, Eugene
name: Paklina, Oxana
name: Li, Haiyan I.
name: Willis, Joseph E.
name: Gardner, Johanna
name: Beroukhim, Rameen
name: Button, Michael
name: Dhankani, Varsha
name: Baylin, Stephen B.
name: Holt, Robert A.
name: Armenia, Joshua
name: Ojesina, Akinyemi I.
name: Nistelrooij, Anna Van
name: Wong, Rebecca
name: Sankarankutty, Ajith Kumar
name: Voronina, Olga
name: Seoane, Jose A.
name: Chin, Lynda
name: Chalmers, Sally
name: DInjens, Winand
name: Force, Seth
name: Pedamallu, Chandra Sekhar
name: Lucchesi, Fabiano
name: Liu, Geoffrey
name: Lolla, Laxmi
name: Schumacher, Steven E.
name: Gehlenborg, Nils
name: Darling, Gail
name: Balasundaram, Miruna
name: Sakai, Ku Leuven Ryo
name: Moore, Richard A.
name: Dubina, Michael
name: Reis, Rui Manuel
name: Hoadley, Katherine A.
name: Lee, Ju-Seog
name: Wang, Kenneth
name: Gabriel, Stacey B.
name: Berrios, Mario
name: Dhalla, Noreen
name: Ren, Xiaojia
name: Stewart, Chip
name: Arora, Arshi
name: Hwang, Jun-Eul
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Oesophageal cancers are prominent worldwide; however, there are few targeted therapies and survival rates for these cancers remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas of the oesophagus derived from Western and Eastern populations. Beyond known histopathological and epidemiologic distinctions, molecular features differentiated oesophageal squamous cell carcinomas from oesophageal adenocarcinomas. Oesophageal squamous cell carcinomas resembled squamous carcinomas of other organs more than they did oesophageal adenocarcinomas. Our analyses identified three molecular subclasses of oesophageal squamous cell carcinomas, but none showed evidence for an aetiological role of human papillomavirus. Squamous cell carcinomas showed frequent genomic amplifications of CCND1 and SOX2 and/or TP63, whereas ERBB2, VEGFA and GATA4 and GATA6 were more commonly amplified in adenocarcinomas. Oesophageal adenocarcinomas strongly resembled the chromosomally unstable variant of gastric adenocarcinoma, suggesting that these cancers could be considered a single disease entity. However, some molecular features, including DNA hypermethylation, occurred disproportionally in oesophageal adenocarcinomas. These data provide a framework to facilitate more rational categorization of these tumours and a foundation for new therapies.