cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Cliff-dwellers of the San Juan Valley
Creators: name: Judd, Neil Merton
Publisher: name: University of Utah
Year: 2012
Subjects: San Juan River Valley--Archaeology

description: In treating a thesis of this nature, the student  of history undertakes much. Not only does he draw the antagonism  of those who have already formed conclusions on the  subject he treats, but he also receives the criticism of other  students whose theories fail to harmonize with his. , In preparing  this paper, the writer has not attempted to produce a  monumental work that should stand for all time, but rather  to give in simple language the results of his personal observations  and study, that others may gain the same picture of prehistoric  life that he has gained. Future observations will  no doubt disprove many of these conclusions, but the author  believes that every impression herein conveyed is supported by  the latest archaeological research. The text has been limited to the so-called "Cliffdwellers"  of the San Juan Valley because those individuals  represent possibly the highest stage reached by the ancient  inhabitants of the district under consideration.
Study of the Lewis Q-sort
Creators: name: Stanger, Linley Maurine
Publisher: name: University of Utah
Year: 2012
Subjects: Self Concept
Evaluation Studies

description: Today there is an increased interest in research with regard to self concept and its implications for therapy. One of the major problems is the measurement of self concept.  The present study sought to further analyze the Lewis self concept Q-sort by determining the strength of each item in relation to the sub-scales of:   self evaluation, interpersonal relations, physical feelings, and psychological feelings.   Forty-six graduate and undergraduate students from the College of Nursing at the University of Utah participated in this study.   The Lewis Q-sort was administered to the 46 subjects with the instructions to sort the Q-sort once for their present self concept and once for their ideal self concept.  Pearson product-moment correlations and a factor analysis were obtained on the data.   In view of the findings, it was suggested that all of the items are not uniquely measuring present and ideal self concept on the specific sub-scale dimensions.   The results did indicate many of the items had strength or relatedness to the total test content.
Coprophanaeus Olsoufieff 1924
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Coprophanaeus

description: COPROPHANAEUS Olsoufieff, 1924
Phanaeus (Coprophanaeus) Olsoufieff 1924: 64
Synopsis. Edmonds and Zídek 2010
Subgenus COPROPHANAEUS Olsoufieff, 1924
Coprophanaeus Olsoufieff 1924: 64
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 94, DOI: 10.5281/zenodo.3678492
Derivation of evaluation survey data from proficiency testing for infectious mononucleosis
Creators: name: Taylor, Roger Norris
Publisher: name: University of Utah
Year: 2012
Subjects: Monuncleosis

description: Two standard tests for infectious mononucleosis (the Davidsohn differential and the ox cell hemolysin test) and ten slide tests  Monotest (Wampole), Monospot (Ortho), Monosticon (Organon), Diagluto I. M. (Beckman), I. M. Kit (Micro. Res. Corp.), Mono-Diff (Wampole), Bacto-Hetrol (Difco), Monosticon Dri-Dot (Organon), Monophile (BDS) and Rythrotex (BMC)  were evaluated as they were used in 50 laboratories within the state of Utah plus two referee laboratories outside the state.  The state proficiency testing program for infectious mononucleosis was modified so that the desired evaluation survey data could be obtained.  The sensitivity, specificity, reproducibility (within and between shipments) and percent agreement with target results were determined for each test.  Factors which might have affected the test results were evaluated to determine which were correlated with good performance.  These factors included:  formal education of the technologist performing the test, professional affiliation of the technologist, technologist's experience, technologist's area  of major interest, type of laboratory, size of laboratory, number of tests performed, use of the test (screen, confirm or both), technologist's experience with the test and procedural differences.  Since there is a critical need for evaluation survey data in almost every area of clinical laboratory testing and since there are in existence numerous proficiency testing programs in these areas, it is felt that an enormous amount of valuable information could be relatively easily obtained by similar modifications of existing proficiency testing programs.
The chemistry of the nucleic acids.
Creators: name: Westcott, Wayne L.
Publisher: name: University of Utah
Year: 2012
Subjects: Analysis
Nucleotides

description: Much more is known about the components of pentose nucleic acid than is known about those of desoxypentose nucleic acid.  However, the manner of the inter-nucleotide linkage of both is still unknown.  An experimental approach was suggested in an attempt to settle this point for the pentose nucleic acids.  Because of the extreme lability of the carbohydrate component of the desoxypentose nucleic acid a different experimental approach to the problem of inter-nucleotide linkage must be found.  2-desoxy-D-ribose has been demonstrated only in the guanosine isolated from the desoxypentose nucleic acid and its furatnose structure was demonstrated indirectly in thymidine.  Infra-red studies might be carried out by determining the characteristic patters of all the known constituents of both types of the nucleic acids as well as of the nucleic acids isolated from different sources and "purified" by different methods.  In this manner it may be possible to gain an insight into the over-all structures of the nucleic acid macromolecules.  Studies with labeled nitrogen in the ring structure of the nitrogenous bases should be extended.  The amount of each of the nitrogenous bases in the different nucleic acids could be readily determined by means of isotope dilution using the paper chromatograph for final separation.  The incorporation of N15 in the ring structure of adenine at position (7) or (9) would provide a labeled nitrogenous base.  This would be added to the nucleic acid before hydrolysis.  The adenosine could be isolated from the hydrolysate chromatographically and the amount of adenine originally present in the nucleic acid could be determined.  This procedure would have to be repeated for each nitrogenous base in order to determine the amounts originally present in the nucleic acids.  Enzymatic studies also have shown the probability of more than one type of inter-nucleotide linkage occurring within the nucleic acid macromolecule.  One type is thought to be quite resistant to enzymatic action as only about thirty percent of the nucleic acid is hydrolyzed under optimal conditions.  It is suggested that the nucleic acids be partially hydrolyzed by the "depolymerases" and that both the hydrolyzed and non-hydrolyzed fractions be subjected to exhaustive methylation.  Subsequent determinations of the carbohydrate oxidation products would aid in the location of the inter-nucleotide linkages.
Maternal postural selections during active phase of first stage labor
Creators: name: Capalbo-Moore, Laurie J.
name: Jacobellis, Jillian M.
Publisher: name: University of Utah
Year: 2012
Subjects: Labor (Obstretrics)
Posture

description: The first stage labor was studied in a primary care facility.  Thirty women were assigned to either experimental or comparison groups biased coin randomization.  The experimental group was give explicit verbal permission to assume any position of conform and were shown illustration of possible beneficial position.  The experimental group made significantly greater use or vertical spine and kneeling positions.  The comparison group made significantly great use of the low lateral recumbent position.  These data indicate that women are susceptible of permission and information given them during the active phase of labor.  Differences between nurse-midwife and physician client groups and the postural patterns during the active phase were also examined.
Sonnenfleckenzeichnung Nr. 22734.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 16.03.1968, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 23.01.1968, erstellt von Peter Rovithis, Eugenides Planetarium in Athen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Eugenides Planetarium in Athen der Eugenides Stiftung, Griechenland. Instrument: Zeiss (Coudé-Refraktor 150mm, projiziertes Sonnenbild D = 25cm)
Coprophanaeus (Coprophanaeus) abas
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Coprophanaeus
Coprophanaeus abas

description: § Coprophanaeus (Coprophanaeus) abas (MacLeay, 1819)
Phanaeus jasius abas? MacLeay 1819: 127 (Trinidad and Tobago - NEOTYPE)
Distribution. Brazil (NA): Pacheco and Vaz-de-Mello 2015: 2 (NA). Venezuela (EO): Arnaud 2002c: 28; Edmonds and Zídek 2010: 50 (EO). Other: MacLeay 1819: 127 (Trinidad and Tobago - as Phanaeus jasius abas?); Gillet 1911b: 84 (Trinidad and Tobago - treated as a synonym of C. jasius); Olsoufieff 1924: 65 (treated as a variety of C. jasius); Blackwelder 1944: 209 (treated as a synonym of C. jasius); Arnaud 2002b: 3 (Trinidad and Tobago - designation NEOTYPE Phanaeus jasius var. abas); Edmonds and Zídek 2010: 50 (Colombia, Trinidad and Tobago).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 94, DOI: 10.5281/zenodo.3678492
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 05.01.1968, erstellt von Peter Rovithis, Eugenides Planetarium in Athen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Eugenides Planetarium in Athen der Eugenides Stiftung, Griechenland. Instrument: Zeiss (Coudé-Refraktor 150mm, projiziertes Sonnenbild D = 25cm)
Sonnenfleckenzeichnung Nr. 22725.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 05.03.1968, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Additional file 1 of A retrospective descriptive analysis of non-physician-performed prehospital endotracheal intubation practices and performance in South Africa
Creators: name: Wylie, Craig A.
name: Araie, Farzana
name: Hendrikse, Clint
name: Burke, Jan
name: Joubert, Ivan
name: Hardy, Anneli
name: Stassen, Willem
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1.
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 23.02.1968, erstellt am Kandilli Observatorium Istanbul
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Istanbul Kandilli Rasathanesi, Çengelköy (Istanbul). Instrument: Refraktor Teleskop (Öffnung 200 mm, f = 3070 mm, projiziertes Sonnenbild D = 25 cm).
Instrumentennachweis gemäss Kandilli Observatory Istanbul, Report from Solar Institute, in: Solar Physics, 1968, Vol. 3, Issue 3, pp.491-492, DOI: https://doi.org/10.1007/BF00171622
Bioactive compounds derived from the marine-derived fungus MCCC3A00951 and their influenza neuraminidase inhibition activity in vitro and in silico
Creators: name: Liu, Shun-Zhi
name: He, Feng-Ming
name: Bin, Yan-lin
name: Li, Chu-Fang
name: Xie, Bao-Ying
name: Tang, Xi-Xiang
name: Qiu, Ying-Kun
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Penicillium polonicum MCCC3A00951 is a fungus with influenza neuraminidase (NA) inhibition activity derived from a sediment of the mangrove forest of Zhangjiangkou in Fujian province, China. Chemical investigation on an ethyl acetate extract of its fermentation led to the isolation of a new compound, 7-hydroxy-3,10-dehydrocyclopeptine (1), and 13 known compounds (2–14). The new compound was comprehensively characterised by high-resolution electrospray ionisation-mass spectrometry, and 1D, 2D nuclear magnetic resonance (NMR) spectra. The anti-influenza NA assay was performed to evaluate the potential biological activity. Surprisingly, Cyclopenin (2) showed potent influenza NA inhibition with an IC50 value of 5.02 μM. Besides, molecular docking simulation was performed to investigate the binding model of cyclopenin (2) with influenza NA. Consequently, cyclopenin (2) could be further optimised to be a potential anti-influenza NA candidate.
Govanoside B, a new steroidal saponin from rhizomes of Trillium govanianum
Creators: name: Singh, Prithvi Pal
name: Suresh, Patil Shivprasad
name: Bora, Prateek Singh
name: Bhatt, Vinod
name: Sharma, Upendra
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Trillium govanianum, commonly known as Nag Chhatri and Teen Patra, is a popular herbal supplement traditionally used for curing different inflammatory and sexual disorders, infection and wound healing. Steroidal saponins are considered as active components of this species. The present study demonstrated the isolation of nine steroidal saponins, including one new compound named as govanoside B (9) and eight known, pregna-chacotrioside (1), pennogenin-triglycoside (2), borassoside E (3), pennogenin-tetraglycoside (4), protodioscin (5), clintonioside B (6), pennogenin-diglycoside (7) and borassoside D (8). This is the first report on the isolation of 1, 2, 4, 5, 6, 7 and 8 from rhizomes of T. govanianum. The extract, fractions and isolated compounds were further evaluated for their DPPH and ABTS radical scavenging activity.
Sonnenfleckenzeichnung Nr. 22699.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 28.01.1968, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Coprophanaeus (Coprophanaeus) christophorowi
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Coprophanaeus
Coprophanaeus christophorowi

description: Coprophanaeus (Coprophanaeus) christophorowi (Olsoufieff, 1924)
Phanaeus (Coprophanaeus) christophorowi Olsoufieff 1924: 66 (French Guiana)
Distribution. French Guiana: Olsoufieff 1924: 25, 66; Blackwelder 1944: 209; Feer 2000: 32; Arnaud 2002c: 37; Feer and Pincebourde 2005: 30; Edmonds and Zídek 2010: 85; Brûlé et al. 2011a: 193, 2014: 183; Brûlé and Dalens 2012b: 37; Boilly et al. 2016: 90; MHCN. Brazil (NA): Arnaud 2002c: 37 (NA).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 94, DOI: 10.5281/zenodo.3678492
Fatalism, Climate Resiliency Training and Farmers’ Adaptation Responses: Implications for Sustainable Rainfed-Wheat Production in Pakistan
Creators: name: Mahmood, Nasir
name: Arshad, Muhammad
name: Kaechele, Harald
name: Shahzad, Muhammad Faisal
name: Ullah, Ayat
name: Mueller, Klaus
Publisher: name: Humboldt-Universität zu Berlin
Year: 2020
Subjects: subject: fatalism
subject: climate-specific extension services
subject: climate-resilient farming
subject: rainfed farming
subject: adaptation
subject: 333.7 Natürliche Resourcen, Energie und Umwelt
subject: 690 Hausbau, Bauhandwerk

description: Climate change is a severe threat to the agricultural sector in general and to rainfed farming in particular. The aim of this study was to investigate the factors that can potentially affect the adaptation process against climate change. This study focused on wheat farmers and farming systems in the rainfed agroecological zone of Pakistan. Farmers’ data related to climate change fatalism, the availability of climate-specific extension services, socioeconomic and institutional variables, and farm characteristics were collected. A logit model to assess farmers’ decisions to adopt an adaptation measure and a multinomial logit model to assess their choice of various adaptation measures were used. The results showed that fatalistic farmers were unlikely to implement climate change adaptation measures. The variables related to the climate-specific extension services, including farmers’ participation in training on climate-resilient crop farming and the availability of mobile communication-based advisory services, had highly significant and positive impacts on farmers’ decisions and their choice of adaptation measures. Input market access and tractor ownership also had positive and significant impacts on farmers’ decisions to adapt and their choice of adaptation measures. This study highlights the need to improve rainfed-wheat farmers’ education levels to change their fatalistic attitudes towards climate change. Furthermore, government action is needed to provide climate-specific extension services to ensure sustainable production levels that will ultimately lead to food and livelihood security under a changing climate.
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 22.02.1968, erstellt von Georgeta Maris, Observatorium Bukarest
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage am Astronomischen Observatorium Bukarest, Solarsektor, Rumänien. Instrument: Zeiss-Refraktor (Öffnung 130mm, f = 1950mm, projiziertes Sonnenbild D = 25cm)
Sonnenfleckenzeichnung Nr. 22696.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 17.01.1968, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 22.02.1968, erstellt von Peter Rovithis, Eugenides Planetarium in Athen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Eugenides Planetarium in Athen der Eugenides Stiftung, Griechenland. Später wurden ergänzende Angaben aufgrund weiterer Beobachtungen auf einem separaten Blatt festgehalten und zur Fleckenzeichnung hinzugefügt. Instrument: Zeiss (Coudé-Refraktor 150mm, projiziertes Sonnenbild D = 25cm)
Zusätzlich ist vorhanden: Blatt mit Handnotizen
Macrotricolorin A, a new diarylpropanoid from the Vietnamese plant Macrosolen tricolor (Lecomte) Danser
Creators: name: Le, Kieu Hung
name: Bui, Thi Kim Ngan
name: Pham, Nguyen Kim Tuyen
name: Dang, Van Son
name: Ngo, Trong Nghia
name: Phan, Nhat Minh
name: Bui, Trong Dat
name: Tran, Trong Duc
name: Nguyen, Quan Hien
name: Ngo, Quoc Luan
name: Tri, Dinh
name: Nguyen, Tan Phat
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: From the Vietnamese plant Macrosolen tricolor (Lecomte) Danser, one new diarylpropanoid, named macrotricolorin A (1) together with three diarylheptanoids including bisdemethoxycurcumin (2), demethoxycurcumin (3) and curcumin (4), were isolated. Their structures were elucidated by intensive analyses of their IR, UV, HR-ESI-MS and NMR (1 D & 2 D) spectra. It is the first time that diarylalkanoids have been reported from the genus Macrosolen. Compound 1 exhibited anti-inflammatory activity against the nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 with an IC50 value of 27.54 ± 1.75 μM.
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 09.01.1968, als Blatt eröffnet dank auswärtiger Beobachtungen, ausgewertet in Zürich
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung bzw. Auswertung aufgrund auswärtiger Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen direkt auf dem Vordruck, erstellt durch Mitarbeitende der Eidgenössischen Sternwarte Zürich
title: Distributed training of recurrent neural networks by FGM protocol
title: Κατανεμημένη εκπαίδευση αναδρομικών νευρωνικών δικτύων με την χρήση γεωμετρικής μεθόδου
Creators: name: Μπαλαμπανης Ηλιας
Publisher: name: Technical University of Crete
Year: 2020

description: Artificial Neural Networks are appealing because they learn by example and are strongly supported by statistical and optimization theories. The usage of recurrent neural networks as identifiers and predictors in nonlinear dynamic systems has increased significantly. They can present a wide range of dynamics, due to feedback and are also flexible nonlinear maps. Based on this, there is a need for distributed training on these networks, because of the enormous datasets. One of the most known protocols for distributed training is the Geometric Monitoring protocol. Our conviction is that this is a very expensive protocol regarding the communication of nodes. Recently, the Functional Geometric Protocol has tested training on Convolutional Neural Networks and has had encouraging results. The goal of this work is to test and compare these two protocols on Recurrent Neural Networks.
description: Τα Νευρωνικά Δίκτυα είναι ελκυστικά επειδή μαθαίνουν από τα δεδομένα και υποστηρίζονται έντονα από τις θεωρίες στατιστικής και βελτιστοποίησης. Η χρήση των Αναδρομικών Νευρωνικών Δικτύων για την πρόγνωση σε μη γραμμικά δυναμικά συστήματα έχει αυξηθεί σημαντικά. Αυτά έχουν την δυνατότητα να παρουσιάσουν ένα ευρύ φάσμα δυναμικής, λόγω της ανατροφοδότησης στην αρχιτεκτονικής τους. Βασιζόμενοι σε αυτό, προκύπτει η ανάγκη για κατανεμημένη εκπαίδευση σε αυτά τα δίκτυα, λόγω των τεράστιων δεδομένων. Ένα από τα πιο γνωστά πρωτόκολλα για κατανεμημένη εκπαίδευση είναι το πρωτόκολλο Γεωμετρικής Παρακολούθησης. Η πεποίθησή μας είναι ότι αυτό είναι ένα πολύ ακριβό πρωτόκολλο όσον αφορά την επικοινωνία των κόμβων, όταν το δίκτυο γίνεται όλο και μεγαλύτερο. Πρόσφατα, το Functional Geometric Monitoring πρωτόκολλο έχει δοκιμαστεί στην εκπαίδευση των  Συνελικτικών Νευρωνικών Δικτύων και είχε ενθαρρυντικά αποτελέσματα. Ο στόχος αυτής της εργασίας είναι να δοκιμάσει και να συγκρίνει αυτά τα δύο πρωτόκολλα στα Αναδρομικά Νευρωνικά Δίκτυα.
Additional file 1 of Understanding the post-2010 increase in food bank use in England: new quasi-experimental analysis of the role of welfare policy
Creators: name: Sosenko, Filip
name: Bramley, Glen
name: Bhattacharjee, Arnab
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Computational Biology

description: Additional file 1. Variables considered for the modelling.
Sonnenfleckenzeichnung Nr. 22708.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 10.02.1968, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
First complete NMR data and theoretical study of an antimicrobial formylated dihydrochalcone from Psidium guineense Sw
Creators: name: Lima, Ewerton M.
name: Fernando, Luciana M.
name: Felix, Leonardo P.
name: de Oliveira Filho, Abrahão A.
name: Neto, Albano N. Carneiro
name: Moura, Renaldo T.
name: Teles, Yanna C. F.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: Chalcones are a widespread group of natural compounds characterized by the basic structure 1,3-diaryl-2-propen-1-one. In this study, we focused on the uncommon formylated chalcone 3’-formyl-2’,4’,6’-trihydroxy-5’-methyldihydrochalcone that possess interesting antimicrobial and anticancer potential. Considering the pharmacological relevance of this compound, we report its isolation and the first complete and unequivocal NMR data for this substance, corroborated by in silico theoretical study. In addition to that, its antibacterial potential was evaluated and the compound presented strong activity against Pseudomonas aeruginosa.
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 21.02.1968, erstellt am Kandilli Observatorium Istanbul
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Istanbul Kandilli Rasathanesi, Çengelköy (Istanbul). Instrument: Refraktor Teleskop (Öffnung 200 mm, f = 3070 mm, projiziertes Sonnenbild D = 25 cm).
Instrumentennachweis gemäss Kandilli Observatory Istanbul, Report from Solar Institute, in: Solar Physics, 1968, Vol. 3, Issue 3, pp.491-492, DOI: https://doi.org/10.1007/BF00171622
Additional file 2 of Understanding the post-2010 increase in food bank use in England: new quasi-experimental analysis of the role of welfare policy
Creators: name: Sosenko, Filip
name: Bramley, Glen
name: Bhattacharjee, Arnab
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Computational Biology

description: Additional file 2. Omitted variable bias.
Additional file 3 of Understanding the post-2010 increase in food bank use in England: new quasi-experimental analysis of the role of welfare policy
Creators: name: Sosenko, Filip
name: Bramley, Glen
name: Bhattacharjee, Arnab
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Computational Biology

description: Additional file 3. Dynamics.
Coprophanaeus (Coprophanaeus) dardanus
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Coprophanaeus
Coprophanaeus dardanus

description: Coprophanaeus (Coprophanaeus) dardanus (MacLeay, 1819)
Phanaeus dardanus MacLeay 1819: 126 (Brazil)
= Phanaeus jasion Felsche 1901: 153 (French Guiana)
Distribution. Guyana: Forsyth and Gill 1993: 70; Edmonds and Zídek 2010: 80. Suriname: Edmonds and Zídek 2010: 80; Larsen 2011: 99; MHCN, NZCS, RMNH. French Guiana: Felsche 1901: 153 (as Phanaeus jasion); Gillet 1911b: 83 (as Phanaeus jasion); Olsoufieff 1924: 69 (as Phanaeus (Coprophanaeus) dardanus; as Phanaeus (Coprophanaeus) jasion); Blackwelder 1944: 210 (as Phanaeus jasion); Feer 2000: 32; Arnaud 2002c: 32; Feer and Pincebourde 2005: 30; Edmonds and Zídek 2010: 80; Brûlé et al. 2011a: 193, 2011b: 121, 2014: 183; Brûlé and Dalens 2012b: 37; Brûlé and Touroult 2013: 40; Boilly et al. 2016: 90; MHCN. Brazil (NA): MacLeay 1819: 126 (Phanaeus dardanus); Gillet 1911b: 82 (Phanaeus dardanus); Olsoufieff 1924: 69 (as Phanaeus (Coprophanaeus) dardanus); Blackwelder 1944: 209 (Phanaeus dardanus); Vaz-de-Mello 2000: 192; Arnaud 2002c: 32; Gardner et al. 2008: table S1 (NA); Edmonds and Zídek 2010: 80 (NA); Pacheco and Vaz-de-Mello 2015: 2 (NA). Venezuela (EO): Arnaud 2002c: 32; Edmonds and Zídek 2010: 80 (EO); Ferrer-Paris et al. 2013: 109 (EO). Other: Gillet 1911b: 82 (Mexico - as Phanaeus dardanus); Blackwelder 1944: 209 (Mexico - as Phanaeus dardanus); Edmonds and Zídek 2010: 80 (Colombia, Trinidad and Tobago).
Note. The record of Coprophanaeus dardanus from Mexico in Gillet (1911b: 82) and Blackwelder (1944: 209) as Phanaeus dardanus appears to be based on a mislabeled or misidentified specimen. This species does not occur in Mexico according to Edmonds and Zídek (2010: 80).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 94, DOI: 10.5281/zenodo.3678492
Sonnenfleckenzeichnung, unnummeriert.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 11.02.1968, erstellt von Peter Rovithis, Eugenides Planetarium in Athen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Bleistift, erstellt als Zeichnung nach eigener Vorlage am Eugenides Planetarium in Athen der Eugenides Stiftung, Griechenland. Instrument: Zeiss (Coudé-Refraktor 150mm, projiziertes Sonnenbild D = 25cm)
Sonnenfleckenzeichnung unnummeriert, einen Zürcher Lückentag ergänzend.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 07.01.1968, erstellt von Vasile Dinulescu, Observatorium Bukarest
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift, erstellt als Zeichnung nach eigener Vorlage am Astronomischen Observatorium Bukarest, Solarsektor, Rumänien. Instrument: Zeiss-Refraktor (Öffnung 130mm, f = 1950mm, projiziertes Sonnenbild D = 25cm)
Dibenzocyclooctadiene lignans from the stems of Schisandra sphaerandra
Creators: name: Ying, You-Min
name: Yu, Hang-Fei
name: Rao, Gui-Wei
name: Wang, Jian-Wei
name: Shan, Wei-Guang
name: Zhan, Zha-Jun
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Plant Biology

description: Chemical investigation into the stems of the medicinal plant Schisandra sphaerandra led to the isolation and identification of a new dibenzocyclooctadiene lignan sphaerandrin A (1) and 11 known ones gomisin B (2), schirubrisin B (3), kadsuphilin B (4), schizandrin (5), benzoylgomisin Q (6), angeloylgomisin Q (7), gomisin G (8), schisanwilsonin O (9), isogomisin O (10), schisantherin D (11), and wuweizisu C (12). The structure of the new compound was elucidated by comprehensive spectroscopic methods including 1 D/2D NMR, HRESIMS, and CD spectrometry. To the best of our knowledge, compounds 2 – 11 were obtained from this species for the first time. All the compounds were evaluated for the cytotoxic activity against the triple-negative breast cancer cell lines MDA-MB-231 and HCC-1937.
Sonnenfleckenzeichnung Nr. 22715.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 19.02.1968, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Sonnenfleckenzeichnung Nr. 22700.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 29.01.1968, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel. Es sind Angaben zu Protuberanzen vermerkt
Sonnenfleckenzeichnung Nr. 22728.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 09.03.1968, erstellt von Fritz Riesen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Corn Response to Nitrogen Fertilizer Application Timings and After-Market Planter Equipment in a Rye Cover Crop System
Creators: name: Seavers, Riley J
name: Quinn, Daniel
Publisher: name: Purdue University Graduate School
Year: 2024
Subjects: classificationCode: 300403
subject: Agronomy

description: Previous research has documented rye (Secale cereale L.) cover crop (RCC) benefits on weed suppression, erosion control, and water quality. However, RCC adoption is often low prior to corn (Zea mays L.) due to observed yield losses caused by a RCC. Therefore, further research is required to understand and develop corn agronomic, planting equipment, and N fertilizer timing recommendations following a RCC to minimize crop stress and yield losses. The objective of this research was to evaluate corn performance and yield in response to different N fertilizer application timings and after-market closing wheel types following a RCC using multiple field-scale environments. Treatments within the N timing study included three N fertilizer timings (2x2 starter + V5 sidedress, 2x2 + V10, and 2x2 + V5 + V10) and two RCC treatments (RCC and no RCC). Treatments within the closing wheel study included three closing wheel types: Standard Rubber (SR), Cruiser Extreme (CE), and Cupped Razor (MCR), and two RCC treatments (RCC and no RCC. Both studies were conducted at field-scale using commercial equipment at four locations in Indiana in 2022 and 2023. In the N timing study a significant (P<0.1) RCC x N timing interaction was observed in 5 of 6 site-years, indicating optimum N fertilizer timing differs with the presence of a RCC. Without the inclusion of a RCC, the use of a 5x5 + V10 or 5x5 + V5 + V10 N application decreased yield in 4 of 6 and 0 of 6 site-years, respectively when compared to a 5x5 + V5 N application. Whereas, with a RCC the use of a 5x5 + V10 or 5x5 + V5 + V10 N decreased yield in 6 of 6 and 2 of 6 site-years, respectively when compared to a 5x5 + V5 N application. In the closing wheel study, aftermarket closing wheels showed no difference in daily emergence timing and/or final plant stand in no-till conditions without a RCC. However, in RCC treatments, the CE improved total percent corn emergence [7 – 12 days after planting (DAP)] by 6 and 15% at 2 of 3 site-years. Whereas, the MCR improved percent corn emergence (7-12 DAP) by 8% in 1 of 3 site-years. Furthermore, corn grain yield was increased by 5-8 bu ac-1 at 2 of 3 site-years with CE when following a RCC and by 7 bu ac-1 at 1 of 3 site-years with MCR when following a RCC. Overall, results suggest farmers can combine the use of after-market closing wheels designed for high residue/RCC systems and optimum N fertilizer application timing (5x5 + V5 sidedress) to improve corn emergence, reduce N stress, and improve yield following a RCC.
Sonnenfleckenzeichnung Nr. 22730.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 12.03.1968, erstellt von Werner Scheidegger
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1968

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Zeiss Coudé-Refraktor (150/2250 mm).
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Später wurden ergänzende Angaben aufgrund auswärtiger Beobachtungen direkt auf der Fleckenzeichnung hinzugefügt. Zusätzlich notiert: Tabelle mit statistischen Angaben – mit Vermerk der Werte Gr, f und g, wobei die Bestimmung der Fleckenrelativzahl nach wie auf visueller Beobachtung und anderer Instrumentierung beruhte (und dafür das entsprechende Registerblatt (in Teilbestand acht) ausgefüllt wurde). Zusammen mit den täglichen Werten oft Angabe der Resultate der Flächenmessungen der Flecken (F und F -o) in Millionsteln der Scheibe bzw. der Halbkugel
Coprophanaeus (Coprophanaeus) gamezi Arnaud 2002
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Coprophanaeus
Coprophanaeus gamezi

description: Coprophanaeus (Coprophanaeus) gamezi Arnaud, 2002
Coprophanaeus (Coprophanaeus) gamezi Arnaud 2002a: 8 (Venezuela (EO))
Distribution. Guyana: Edmonds and Zídek 2010: 52. Brazil (NA): Edmonds and Zídek 2010: 52 (NA); Pacheco and Vaz-de-Mello 2015: 2 (NA); França et al. 2016: 2 (NA). Venezuela (EO): Arnaud 2002a:
8 (EO), 2002c: 29; Edmonds and Zídek 2010: 52 (EO); Ferrer-Paris et al. 2013: 109. Other: Edmonds and Zídek 2010: 52 (Colombia).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on pages 94-95, DOI: 10.5281/zenodo.3678492
Celosiadines A and B, unusual guanidine alkaloids from Iresine diffusa
Creators: name: Killian, Caroline
name: Johnson, Shelby L.
name: Ma, Hang
name: McKeown, Brendan
name: McDougall, Luke
name: Hurta, Robert
name: Liu, Yongqiang
name: Seeram, Navindra P.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Two unusual di-isopentenyl guanidine alkaloids, named celosiadines A (1) and B (2), were isolated from Iresine diffusa aerial parts. The structures of the compounds were elucidated from extensive spectroscopic analyses including HRMS, NMR and ECD. Celosiadines A and B showed favorable binding affinity to the androgen receptor (AR) in silico and were cytotoxic towards AR-sensitive (LNCaP) but not AR-insensitive (PC3) human prostate cancer cells in vitro.
Functional Analysis of the Mitochondrial Proteome in Drosophila
Creators: name: Bricker, Daniel Kevin
Publisher: name: University of Utah
Year: 2014
Subjects: Drosophyllum - Research
Mitochondria Diseases

description: Mitochondria are complex organelles that have important roles in energy production, intermediary metabolism, signal transduction, and apoptosis. Given these critical cellular functions, major efforts have been made to determine the identity of the mitochondrial proteome. Remarkably, about one fifth of mitochondrial proteins have unknown functions, and many of these are conserved through evolution, suggesting that they play a critical role in mitochondrial biology. We have focused on characterizing a subset of these evolutionarily conserved genes through a collaborative effort in Drosophila and yeast model systems. Through this work, we identified novel components of metabolic pathways involved in energy production, represented by the mitochondrial pyruvate carrier (MPC) and two succinate dehydrogenase complex assembly factors (SDHAFs). The MPC is a multimeric complex comprising the MPC1 and MPC2 proteins. Loss of MPC1 in yeast, Drosophila, and humans results in impaired pyruvate metabolism stemming from a defect in pyruvate import through the inner mitochondrial membrane. A point mutation generated in yeast MPC1 confers resistance to a known inhibitor of the MPC, thus linking our discovery to classic biochemical analysis of mitochondrial pyruvate transport. Moreover, Drosophila MPC1 mutants display hallmarks of diabetes, including hyperglycemia, reduced glucose tolerance, and defects in insulin signaling. Taken together, our results demonstrate that the MPC proteins are iv required for mitochondrial pyruvate transport and, further, that this function is critical for maintaining carbohydrate homeostasis in vivo. SDHAF3 and SDHAF4 are mitochondrial matrix proteins that are required for maximal SDH activity in yeast, Drosophila, and mammalian cells. Both of these proteins interact directly with SDH complex subunits to promote normal assembly of the SDH complex. Moreover, Drosophila Sdhaf3 and Sdhaf4 mutants display hallmarks of mitochondrial dysfunction, including muscular and neuronal dysfunction. These studies provide novel candidate causative loci for human diseases characterized by SDH deficiency. Overall, the work described in this thesis yields key insights into mitochondrial pyruvate transport and succinate dehydrogenase complex assembly, using Drosophila to highlight their importance for energy metabolism and animal physiology.