cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Zentrale Schmerzantwort und Krankheitsaktivität bei Patienten mit Rheumatoider Arthritis nach Therapie mit Certolizumab-pegol vs. Placebo: Eine post-hoc Analyse der PreCePRA Studie
Creators: name: Schenker, Hannah
name: Rech, Jürgen
name: Tascilar, Koray
name: Hagen, Melanie
name: Schönau, Verena
name: Sergeeva, Marina
name: Konerth, Laura
name: Prade, Jutta
name: Strobelt, Sandra
name: Valor Mendez, Larissa
name: Hueber, Axel
name: Simon, David
name: Kleyer, Arnd
name: Behrens, Frank
name: Da Silva, José Antonio P.
name: Baerwald, Christoph
name: Finzel, Stephanie
name: Voll, Reinhard
name: Feist, Eugen
name: Dörfler, Arnd
name: Damjanov, Nemanja
name: Hess, Andreas
name: Schett, Georg
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: In bisherigen Untersuchungen von RA Patienten konnten wir zeigen, dass die zentrale Schmerzantwort auf Kompression eines schmerzhaften Gelenks hin, dargestellt durch ein funktionelles MRT des Gehirns in Abhängigkeit von Blutsauerstoffgehalt (blood-oxygen level dependent=BOLD), [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
title: Patient Reported Outcomes bei rheumatoider Arthritis: Assoziation von autonomer Dysfunktion und Depression
Creators: name: Braunisch, Matthias
name: Oberstadler, Fiona
name: Heinrich, Katrin
name: Bachmann, Quirin
name: Lorenz, Georg
name: Günthner, Roman
name: Heemann, Uwe
name: Schmaderer, Christoph
name: Moog, Philipp
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Bei Patienten mit rheumatoider Arthritis liegt eine chronische Inflammation vor. Zudem gibt es Hinweise, dass eine Störung des autonomen Nervensystems vorliegt. Die Erkrankung an einer rheumatoiden Arthritis wirkt sich auf die Lebensqualität aus. So besteht eine depressive Störung[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
title: Vergleich der Wirksamkeit und Sicherheit von zwei Prednisolon-Dosierungen in der Behandlung von Patienten mit früher rheumatoider Arthritis (CORRA): eine randomisierte, Placebo-kontrollierte, multizentrische Studie
Creators: name: Krause, Dietmar
name: Mai, Anna
name: Timmesfeld, Nina
name: Trampisch, Ulrike
name: Klaaßen-Mielke, Renate
name: Rudolf, Henrik
name: Baraliakos, Xenofon
name: Schmitz, Elmar
name: Fendler, Claas
name: Klink, Claudia
name: Böddeker, Stephanie
name: Saracbasi, Ertan
name: Christoph, Jochen
name: Igelmann, Manfred
name: Menne, Hans-Jürgen
name: Schmid, Albert
name: Trampisch, Hans J
name: Braun, Jürgen
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die meisten treat-to-target (T2T)-Strategien zur Behandlung der rheumatoiden Arthritis (RA) beinhalten den frühzeitigen Einsatz von Methotrexat (MTX). Da dessen Wirkung erst verspätet einsetzt, werden Glukokortikoide meist als Brückentherapie eingesetzt. Welche Dosierung hierbei[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
title: Nerve block of the proximal interphalangeal joints (PIPs) in Rheumatoid arthritis (RA) patients: a prospective pilot study
Creators: name: Elsaman, Ahmed
name: Hamed, Ahmed
name: Radwan, Ahmed
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: RA is among the commonest inflammatory arthritis influencing the hand with devastating impact on function and activities of daily living. Multiple remedies have just been setup for such a disease, but still achieving sustained remission is unattainable or challenging goal. Local therapy[for full text, please go to the a.m. URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
title: A prospective, multicentre study to determine the incidence of rheumatoid arthritis in anti-CPP positive and anti-CPP negative patients who exhibit a new onset of musculoskeletal symptoms
Creators: name: Dauth, Stephanie
name: Köhm, Michaela
name: Oberwahrenbrock, Timm
name: Henkemeier, Ulf
name: Roßmanith, Tanja
name: Mergenthal, Karola
name: Petersen, Juliana J.
name: Burkhardt, Harald
name: Behrens, Frank
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: Strategies for the early detection and diagnosis of Rheumatoid Arthritis (RA) are of high importance as prompt treatment improves clinical and structural outcome. Autoantibodies against cyclic citrullinated proteins (anti-CCP) have been associated with RA-development. Non-specific musculoskeletal[for full text, please go to the a.m. URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Notwendigkeit von bodenschutzbezogenen Regelungen auf EU-Ebene
Creators: name: Frauenstein, Jörg
name: Ginzky, Harald
name: Glante, Frank
name: Grimski, Detlef
name: Ehlers, Knut
name: Marx, Kirstin
Publisher: name: My University
Year: 2018
Subjects: subject: EG-Wasserrahmenrichtlinie
subject: EU-Bodenschutzregelungen
subject: EU-Bodenschutzrecht
subject: Wasserrahmenrichtlinie
subject: land degradation neutrality
subject: Boden | Fläche

description: Das Hintergrundpapier diskutiert Optionen zur Fortentwicklung des EU-Bodenschutzrechts. Mehr Bodenschutz durch EU-Regelungen würde den Erhalt grenzüberschreitender Ökosystemdienstleistungen sicherstellen sowie eine effektive Umsetzung des Ziels „land degradaion neutrality“ ermöglichen. Das Papier erläutert im Anschluss die Vor- und Nachteile der beiden grundsätzlichen Regelungskonzepte – erstens holistisch/planerisch vergleichbar zur ⁠Wasserrahmenrichtlinie⁠ und zweitens sektoral/Mindestregelungen. Konkrete Vorschläge zur Fortentwicklung des EU-Bodenschutzrechts werden für die Bereiche Kontamination, Flächen- und Bodeninanspruchnahme sowie Landwirtschaft unterbreitet.
title: Ist eine radiologische Remission bei Patienten mit einer rheumatoiden Arthritis möglich?
Creators: name: Pfeil, Alexander
name: Nußbaum, Anica
name: Renz, Diane
name: Oelzner, Peter
name: Wolf, Gunter
name: Böttcher, Joachim
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Eine Reduktion der Fingergelenkspaltweite ist mit einer radiologischen Progression einer rheumatoiden Arthritis (RA) verbunden. Aus diesem Grund findet die Fingergelenkspaltweite eine als unabhängiger Parameter eine Berücksichtigung in verschiedenen Scores (z. B. Sharp Score). [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
title: Janus Kinase-Inhibitoren bedingte Hyperlipidämie: Assoziation mit einer Erhöhung der aortalen Steifigkeit bei Patienten mit Arthritis?
Creators: name: Triantafyllias, Konstantinos
name: Thiele, Leif-Erik
name: De Blasi, Michele
name: Schwarting, Andreas
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Therapie mit Janus Kinase-Inhibitoren (JAK-i) kann zu einer Lipiderhöhung bei Patienten mit Arthritis führen [ref:1]. Allerdings können JAK-i zur Reduktion der systemisch-entzündlichen Aktivität beitragen und somit positiv auf das cardiovaskuläre (CV)-System[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
title: Breg-mediated CD4+ T cell suppression is mainly induced by co-inhibitory molecules and can be enhanced by presence of IL-10 and ß-adrenergic receptor activation
Creators: name: Honke, Nadine
name: Opgenoorth, Birgit
name: Schneider, Matthias
name: Pongratz, Georg
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: Regulatory B cells (Bregs) can inhibit inflammation mediated by CD4+ T cells, a crucial population in the pathogenesis of rheumatoid arthritis (RA). Recently, we were able to show that B cells produce their own catecholamines to modulate Breg function. In the current study, we tested[for full text, please go to the a.m. URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
title: Objective assessment of fatigue in rheumatoid arthritis: Can dynamic pupillometry help?
Creators: name: Bachmann, Quirin
name: Kux, Ellen
name: Schlegl, Michaela
name: Lorenz, Georg
name: Braunisch, Matthias
name: Günthner, Roman
name: Heemann, Uwe
name: Schmaderer, Christoph
name: Moog, Philipp
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: In chronic inflammatory disease non-articular symptoms such as fatigue and symptoms of autonomic dysfunction contribute significantly to disease burden. Despite their importance, knowledge about the relationship between inflammation, fatigue and autonomic dysfunction is limited. Since [for full text, please go to the a.m. URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
The metabolic demands of internal medicine residency
Creators: name: Sy, Sarah
name: Sall, Karanvir
name: Dempsey, Erika
name: Tedder, Gale
name: Madden, Kenneth M.
Publisher: name: BioMed Central
Year: 2019

description: Background: North American and European accreditation bodies have legislated progressively more strict work hour restrictions for residents in light of evidence that sleep deprivation leads to increased medical errors and decreased wellbeing. The purpose of the study is to determine the physiologic demands of internal medicine training during residency as well as document average sleep (on- and off-call) and physical activity performed using accelerometers. Methods: A total of 40 internal medicine residents working on the clinical teaching unit at a single center were enrolled in the study from November 2011 to March 2016. There were 22 subjects that completed the study and were included in the analysis. SenseWear PRO 2 armband monitors were worn for 5 consecutive days including one call day. The primary outcomes of the study were to quantify and compare the calories per day, steps per day, METs per hour, hours of activity, hours of sleep, and sleep efficiency for on call versus post-call and non-call days. Results: The average activity per day, calories per day, steps per day and METs per hour for the call day were 7.6 ± 7.6 h, 2647.0 ± 541.1, 11,261.1 ± 2355.9, and 1.7 ± 0.2 respectively. Each of these parameters had a statistically significant F statistic compared to post-call and non-call days. The subjects had a mean of 1.8 ± 2.0 h of sleep per day with a sleep efficiency of 77.3 ± 23.8% for the call day. The F statistic for sleep per day was significant with a p value < 0.001. Conclusion: This study shows that overnight call has a substantial impact on multiple metabolic parameters. These findings have potentially important implications on future resident working hour restrictions.
title: The PROPER Study: A pan-EU real-world study of SB5 biosimilar following transition from reference adalimumab; An interim analysis of patients from the German rheumatoid arthritis cohort
Creators: name: Müller-Ladner, Ulf
name: Zinke, Silke
name: Liebhaber, Anke
name: Utzinger, Maximilian
name: Addison, Janet
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Background: SB5, a biosimilar to reference adalimumab (ADL), received EU marketing authorisation in August 2017, based on the totality of evidence from pre-clinical and clinical Phase I and III studies that demonstrated bioequivalence, similar efficacy, and comparable safety and immunogenicity to the[for full text, please go to the a.m. URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
title: Impact of long-term inflammation to develop neuropathic pain components in patients with rheumatoid arthritis. Results from deep phenotyping of pain profiles using Quantitative Sensory Testing (QST) and contact heat evoked potentials (CHEPs)
Creators: name: Anders, Björn
name: Anders, Malte
name: Köhm, Michaela
name: Geisslinger, Gerd
name: Behrens, Frank
name: Walter, Carmen
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: Pain sensation is of high importance in Rheumatoid Arthritis (RA) patients as inflammation triggers pain development strongly. Although the etiology of pain in RA has a primarily nociceptive character, up to 20% of RA patients suffer from a neuropathic pain component and sensitization.[for full text, please go to the a.m. URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
An assessment of a positive perspective/highlight program on elementary school children.
Creators: name: St Denis, Marnie L.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Education, Guidance and Counseling.

description: The purpose of this study was to assess the effectiveness of a 10 week positive perspective/highlight program developed specifically for elementary school children. Two intact classes of grade four children took part in the study, one experimental and one control. The experimental group participated in various games and activities designed to promote positive perspectives and help the children look for positive highlights in their daily lives. Significant positive effects were found in the experimental group with respect to increased frequencies of highlights, and positive feelings about self following the intervention program. Ten categories emerged from a qualitative analysis of over 2,000 highlights that children recorded in their logbooks: human contact, play/activity, contact with nature, tasting pleasures, accomplishments, discovery, entertainment, receiving/giving, positive anticipation, and relaxation.
Subcellular trafficking of VHL and oxygen homeostasis: Discovery of a new nuclear export pathway
Creators: name: Khacho, Mireille
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Biology, Molecular.
subject: Biology, Cell.

description: Degradation of nuclear proteins by the ubiquitylation system often requires nuclear-cytoplasmic trafficking of E3 ubiquitin-ligases. The von Hippel-Lindau (VHL) tumor suppressor protein is the substrate recognition component of a Cullin-2-containing E3 ubiquitin-ligase that recruits the hypoxia-inducible factor (HIF) for oxygen-dependent degradation. The dynamic properties of VHL are essential for its ability to mediate efficient degradation of HIF. Interestingly, nuclear export of VHL requires ongoing transcription and is independent of the classical NES/CRM1 pathway. Examining this uncharacterized nuclear export pathway led to the identification of a discreet motif, "DxGx2Dx 2L", that directs transcription-dependent nuclear export of VHL. The "DxGx2Dx2L" motif is also found in other proteins, including Poly(A) Binding Protein (PABP1) to direct transcription-dependent nuclear export. The DxGx2Dx2L motif is denoted as TD-NEM (Transcription-Dependent Nuclear Export Motif) since inhibition of transcription by ActD or DRB abrogates its nuclear export activity. In VHL, TD-NEM is targeted by naturally-occurring mutations associated with renal carcinoma and polycythemia in humans. Disease-causing mutations of key residues of TD-NEM restrain the ability of VHL to efficiently mediate oxygen-dependent degradation of HIF by altering its nuclear export dynamics without affecting interaction with its substrate or core components of the E3 ubiquitin-ligase complex. Further studies aimed at understanding the mechanism of TD-NEM-mediated nuclear export led to the identification of a novel VHL and PABP1 interacting protein, the cytoplasmic translation elongation factor eEF1A. eEF1A, which has been implicated in the nuclear export of RNA species in lower eukaryotes, is involved in nuclear export of proteins encoding a TD-NEM in mammalian cells. eEF1A interacts specifically with TD-NEM and disrupting this interaction, by point mutations of the key residues within TD-NEM or siRNA-mediated knockdown of eEF1A, suppresses nuclear export. ActD suppresses eEF1A/TD-NEM interaction and abrogates eEF1A-mediated nuclear export of TD-NEM, providing a possible explanation for the inhibitory effect of ActD on nuclear export of TD-NEM-containing proteins. These results identify a novel and potentially ubiquitous, nuclear export motif, further highlight the role of nuclear-cytoplasmic shuttling of E3 ubiquitin-ligases in degradation of nuclear substrates and provide evidence that disease-causing mutations can target subcellular trafficking. Furthermore, these findings demonstrate that eEF1A, a mediator of RNA export in yeast, has an additional role in the nuclear export of proteins in mammalian cells.
title: Pathologically Increased Ionized Calcium drives inflammation in rheumatoid arthritis through Calcium-sensing receptor-mediated NLRP3 inflammasome
Creators: name: Murthy, Supriya
name: Jaeger, Elisabeth
name: Raps, Stefanie
name: Jung, Sebastian
name: Seifert, Olga
name: Baerwald, Christoph
name: Pierer, Matthias
name: Wagner, Ulf
name: Rossol, Manuela
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: A hallmark of the autoimmune disease rheumatoid arthritis (RA) is synovitis and the erosion of bone which might result in a local increase of extracellular calcium concentration. We have shown in previous studies that increased extracellular calcium activates the NLRP3 inflammasome of [for full text, please go to the a.m. URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
title: Evaluating the impact of persisting pain in patients with rheumatoid arthritis – an introduction to the PAIN-CONTROL study
Creators: name: Baerwald, Christoph G.
name: Stemmler, Edgar
name: Gnüchtel, Sixten
name: Baron, Ralf
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: A remarkable number of patients with rheumatoid arthritis (RA)report persisting pain despite adequate response to anti-inflammatory treatment. Pain perception for these patients may not only result from inflammatory origin, but also from non-inflammatory, e.g. neuropathic, mechanisms and[for full text, please go to the a.m. URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Letting the patrons choose: using EBL as a method for unmediated acquisition of ebook materials
Creators: name: Hardy, Gary
name: Davies, Tony
Publisher: name: Swinburne
Year: 2024

description: For many of our network savvy patrons, accustomed to identifying and instantly obtaining text material, convenience and immediacy are highly valued attributes. The library’s hard copy collection struggles to meet these expectations. For example, should a patron articulate a need for a monograph item which has yet to be added to our collections, it is doubtful whether 'convenience' and 'immediacy' would describe our standard responses. Libraries deal with the time lag inherent in their acquisitions processes by endeavouring to predict demand for particular monograph items, using the skills of collection development staff and other predictors of potential use. Inevitably, some of our scarce monograph materials budgets are wasted on materials for which our predictors or instincts failed us – books which no-one will read. We will spend a not insignificant amount of time and effort in adding them to our collections, and after however many years of inactivity, removing them again. What would happen if we let the patrons choose, without intervening directly in the process? Swinburne University of Technology has implemented the EBL ebook nonlinear lending model. In July 2006 the library loaded the entire EBL list of more than 34,000 thousand records into the catalogue. There is no distinction as far as the partons are concerned between an item which the library has yet to acquire and an item which has been purchased. Patrons can browse and download any of the EBL ebooks. An ebook which has not been purchased is borrowed by the patron, and the library pays a percentage of the list price of the item. Through the application of preset customizable parameters, patrons purchase items without intervention by Library staff. Swinburne is the first library in the world to have loaded all MARC records into the catalogue and allow unmediated loans and automatic unmediated purchasing of the entire EBL collection. There are many advantages in such a model, as well as some potential issues. This paper describes the implementation of the EBL ebook nonlinear lending model at Swinburne University Library, analyses practical issues which were encountered (such as duplicate records of ebooks already held), examines data on expenditure, range of content and usage gathered from July to December 2006, and considers implications for collection development.
Mammalian ISWI gene knockdown modulates growth and differentiation properties of neural progenitor cells
Creators: name: Rennick, Stephen D
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Biology, Molecular.
subject: Biology, Cell.
subject: Health Sciences, Immunology.

description: Epigenetic modifications during cellular differentiation are critical for establishing the expression of tissue specific genes characterizing particular cell types. There are two groups of chromatin modifying enzymes that regulate these processes, the ATP-dependent complexes, and the histone modifying complexes. In ATP-dependent remodelling complexes, the imitation switch (ISWI) group has been studied extensively in the past. ISWI proteins were initially discovered in Drosophila and mammals contain two orthologs called SNF2H and SNF2L. Past experiments demonstrated that these remodelers have distinct roles in cellular differentiation and proliferation SNF2H expression is greatest in proliferating neuroprogenitor populations, whereas SNF2L predominates in mature neurons. Additionally, SNF2H null mice are periimplantation lethal due to defective cellular proliferation. Other studies showed that neuronal cell cultures ectopically expressing increased levels of SNF2L display a dramatic increase in neurite extension and spontaneous differentiation. These findings point to requirements for SNF2L during neuronal differentiation but the distinct manner in which ISWI proteins oversee this process remains unknown. To elucidate the role of ISWI proteins in the regulation of neuronal proliferation and differentiation we used shRNA transfection to stably knockdown the genes of interest in established neuronal cell lines. Concurrently, we examined the growth and differentiation properties of primary neuronal cultures derived from mice functionally ablated for Snf2l. Results in neuroblastoma cultures show that upon Snf2l knockdown proliferation is maintained in 30% of the population under differentiation conditions at 4 days of differentiation. In contrast, Snf2H knockdown cells proliferate normally but undergo extensive apoptosis when induced to differentiate. Aberrant cell replication was also observed in E14.5 and E12.5 neurosphere cultures and resulted in a 2-fold decrease in the number of neurons generated and a 4-fold reduction in astrocyte production at 4 days of differentiation. Moreover, both astrocytes and neurons expressing differentiation markers had reduced neurite extensions and branching patterns suggesting a distinct developmental delay. Taken together these studies define distinct roles for ISWI in growth and differentiation of CNS cells.
An interpretation of high-resolution aeromagnetic data over the Manitouwadge greenstone belt, Ontario, Canada.
Creators: name: Miles, Warner Frederick.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Geophysics.

description: The aim of this study is to interpret aeromagnetic data using 3D techniques. The data consist of eleven high resolution surveys over the Manitouwadge greenstone belt of the Superior Province, Ontario. The interpretation was calibrated to the detailed geological mapping of the area by Zaleski et. al. (1995) The study has three components. First, the data and grid quality were maximized to maintain as much of the high frequency component of the flight line data as possible while minimizing levelling errors and gridding artefacts. Second, a number of 3D interpretation techniques was investigated. Third, the 3D interpretation techniques were applied to the data over the Manitouwadge study area. Grid improvement techniques, particularly micro-levelling and trend reinforcement, were found to be necessary to maximize grid quality. The 3D interpretation techniques used included apparent magnetic susceptibility mapping, analytic signal, horizontal gradient of pseudo-gravity, potential field tilt and Euler deconvolution as well as first and second vertical derivatives. Each method enhances a different component of the total field intensity and complemented each other when interpreted in combination. The apparent susceptibility map combined with the horizontal gradient of pseudo-gravity maxima produced an image that approximates the mapped geology. Calibrating the magnetic interpretation to the known geology allowed the extrapolation of supracrustal rock units into areas of limited geological mapping. The presence of supracrustal units in the engulfing Black Pic tonalitic batholith extends the geological mapping and illustrates regional deformation.
title: Management von Patienten mit axialer Spondylarthritis: Ist die Selbstüberwachung mit einer Smartphone-App machbar? Eine Proof-of-Concept-Studie
Creators: name: Kiltz, Uta
name: Kempin, Robin
name: Richter, Jutta
name: Schlegel, Anna
name: Baraliakos, Xenofon
name: Tsiami, Styliani
name: Andreica, Ioana
name: Bühring, Björn
name: Kiefer, David
name: Braun, Jürgen
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Ziel der Studie ist die Untersuchung einer App zur Aufzeichnung krankheitsspezifischer Endpunkte (PRO) hinsichtlich Nutzbarkeit, Machbarkeit und Äquivalenz von Daten im Management von Patienten mit axialer Spondyloarthritis (axSpA). Methoden: Patienten mit axSpA werden prospektiv[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
title: Effects of anti-TNF-therapy on osteoblastic activity in ankylosing spondylitis – results from a prospective study using PET-MRI of SIJ and spine
Creators: name: Baraliakos, Xenofon
name: Tsiami, Styliani
name: Rischpler, Christoph
name: Bruckmann, Nils-Martin
name: Fendler, Wolfgang
name: Kirchner, Julian
name: Herrmann, Ken
name: Sawicki, Lino Morris
name: Braun, Jürgen
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: The clinical efficacy of tumor necrosis factor inhibitors (TNFi) in patients with axial spondyloarthritis (axSpA) is well established but its effect on new bone formation is still unclear. We aimed to assess the effect of TNFi on bone remodeling processes in the axial skeleton of r-axSpA[for full text, please go to the a.m. URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
title: Linking the Remote Sensing of Geodiversity and Traits Relevant to Biodiversity-Part II: Geomorphology, Terrain and Surfaces
title: Linking the Remote Sensing of Geodiversity and Traits Relevant to Biodiversity-Part II: Geomorphology, Terrain and Surfaces
titleType: AlternativeTitle
Creators: name: Lausch, Angela
name: Schaepman, Michael E.
name: Schweitzer, Christian
name: Skidmore, Andrew
Publisher: name: My University
Year: 2020
Subjects: Geomorphologie
Fluss
Windbedingte Erscheinung
Fernerkundung
Erdbeobachtung
Monitoring

description: The status, changes, and disturbances in geomorphological regimes can be regarded as controlling and regulating factors for biodiversity. Therefore, monitoring geomorphology at local, regional, and global scales is not only necessary to conserve geodiversity, but also to preserve biodiversity, as well as to improve biodiversity conservation and ecosystem management. Numerous remote sensing (RS) approaches and platforms have been used in the past to enable a cost-effective, increasingly freely available, comprehensive, repetitive, standardized, and objective monitoring of geomorphological characteristics and their traits. This contribution provides a state-of-the-art review for the RS-based monitoring of these characteristics and traits, by presenting examples of aeolian, fluvial, and coastal landforms. Different examples for monitoring geomorphology as a crucial discipline of geodiversity using RS are provided, discussing the implementation of RS technologies such as LiDAR, RADAR, as well as multi-spectral and hyperspectral sensor technologies. Furthermore, data products and RS technologies that could be used in the future for monitoring geomorphology are introduced. The use of spectral traits (ST) and spectral trait variation (STV) approaches with RS enable the status, changes, and disturbances of geomorphic diversity to be monitored. We focus on the requirements for future geomorphology monitoring specifically aimed at overcoming some key limitations of ecological modeling, namely: the implementation and linking of in-situ, close-range, air- and spaceborne RS technologies, geomorphic traits, and data science approaches as crucial components for a better understanding of the geomorphic impacts on complex ecosystems. This paper aims to impart multidimensional geomorphic information obtained by RS for improved utilization in biodiversity monitoring. © 2020 by the authors.
Detection of trends in extreme rainfall in the province of Ontario
Creators: name: Bougadis, John
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2003
Subjects: subject: Physical Geography.
subject: Engineering, Civil.

description: Information on intensity-duration-frequency (IDF) of rainfall is commonly required for the design, construction, and management of many water resources projects involving natural hazards, due to extreme rainfall events. Design storms (DS) are determined from IDF relationships. Many hydraulic structures (dams, weirs, culverts, storm sewer systems, etc.) are designed to serve 50 years or more into the future. Yet, these structures are being sized for the climatic conditions based on the past records, before climate change. Thus, new design methods accounting for climatic change are needed to prevent potential losses and damages resulting from under-design. This research addresses the issue of the effect of climate change on design storms. The major objectives of this study are to detect trends in extreme rainfall, and to estimate anticipated changes in return periods of extreme rainfall events due to trends. In this study, trends (which might be attributed to climate change) are estimated for different durations of annual extreme rainfall using the regional average Mann-Kendall's S trend test. Numerical analysis was performed on 44 rainfall stations from the province of Ontario, Canada for a 20 and 25 year time frame. (Abstract shortened by UMI.)
title: The degree of bone marrow edema as detected by magnetic resonance imaging in the sacroiliac joints and the spine suspicious of axial spondyloarthritis in the general population is associated with different factors
Creators: name: Baraliakos, Xenofon
name: Richter, Adrian
name: Feldmann, Daniel
name: Ott, Anne
name: Buelow, Robin
name: Schmidt, Carsten
name: Braun, Jürgen
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: We here identify and compare factors associated with the extension of magnetic resonance imaging (MRI) lesions in the spine and the SIJ suggestive of axial spondyloarthritis (axSpA) in the general population. Methods: Spinal- (sagittal T1/T2 sequences) and SIJ- (semicoronal STIR[for full text, please go to the a.m. URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
An investigation of the qualitative dimensions of motivation and the role that they play in recovery from substance addiction
Creators: name: Berry, Matthew C.
Publisher: name: Swinburne
Year: 2024

description: The aim of this thesis was to investigate whether motivation to quit substance addicted behaviour can be assessed in terms of eight motivational dimensions identified from the psychological literature. A review of the literature of motivation in general psychology is followed by a review of contemporary approaches to understanding addiction and motivation to recover. These are drawn together to form a multidimensional model of motivation, that enables the clinician to assess a particular motivating reason on each of eight dimensions. The first study involved 54 participants who were presenting for inpatient withdrawal at a public facility in Melbourne, Australia. They were asked for the motivating reasons behind their intention to quit their substance-addicted behaviour and 200 reasons were collected. It was found that the eight dimensions were indeed independent constructs in the context of addiction recovery. In the second study 43 participants attended a one-day motivational workshop based upon this multidimensional model of motivation and significant improvements in motivation were recorded at the conclusion of the workshop. In summary this thesis provides evidence that this eight dimensional model of motivation may be of benefit to clinicians working with addicted patients, and several possible directions for future research of this model are proposed.
title: Frequency of disease flares under long-term anti-TNF therapy in patients with early axial spondyloarthritis: results from the etanercept versus sulfasalazine in early axial spondyloarthritis trial
Creators: name: Proft, Fabian
name: Torgutalp, Murat
name: Weiß, Anja
name: Protopopov, Mikhail
name: Rios Rodriguez, Valeria
name: Haibel, Hiltrun
name: Hermann, Kay Geert
name: Althoff, Christian
name: Behmer, Olaf
name: Sieper, Joachim
name: Poddubnyy, Denis
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: Disease flares in axial spondyloarthritis (axSpA) might occur even in patients with otherwise stable disease receiving highly effective anti-inflammatory therapy such as TNF inhibitors. The frequency of disease flares, especially in patients with axSpA receiving long-term stable therapy,[for full text, please go to the a.m. URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Inter-University Sustainability Benchmarking for Canadian Higher Education Institutions: Water, Energy, and Carbon Flows for Technical-Level Decision-Making
Creators: name: Alghamdi, Abdulaziz
name: Haider, Husnain
name: Hewage, Kasun
name: Sadiq, Rehan
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: The education sector is one of the major contributors to the total greenhouse gas (GHG) emissions in Canada, i.e., 16% of total emissions among 11 sectors. Canadian higher education institutions (HEIs) consume around 60% of the total energy fed to the educational sector. Existing tools holistically cover a wide array of functions to assess the sustainability of HEIs. The infrastructure (engineered) systems are the pivotal units responsible for the majority of energy and water consumption and may have been built, retrofitted, or replaced at different times using different materials and technologies. Consequently, infrastructures have varying efficiency, designs, building envelopes, and environmental impacts. For technical-level decision making for improving the engineered systems, HEIs need to be benchmarked on the basis of their water, energy, and carbon flows. A methodology is developed for sustainability assessment of 34 Canadian HEIs that are classified into small, medium, and large sizes based on their number of full-time equivalent students (FTE). Energy, water consumption, number of students, and floor area is measured in different units and are, thus, normalized. The study revealed that the energy source was the primary factor affecting the sustainability performance of an institution. The analysis also revealed that small-sized institutions outperformed medium-to-large-sized institutions.
Negotium, otium et specula : l'Utopie de Thomas More ou la découverte d'un nouveau continent épistémologique.
Creators: name: Morgan, Nicole.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1993
Subjects: subject: Philosophy.

description: En depit de l'epaisseur de la bibliographie sur L'Utopie de Thomas More, touchant a toutes les disciplines, de l'analyse literaire a l'analyse religieuse, en passant par, l'analyse politique, le texte reste enigmatique; les lecteurs les plus rigoureuses ont echoue a rendre compte de maniere exhaustive d'une pensee en apparence incoherente, renforcant, ce faisant, la croyance en une pensee "renaissant", bouillonnante et brouillonne, incapable de formuler des theses autour d'une theorie rationnel le et consistante. Parmi les entreprises les plus interessantes, citons les recherches d'Andre Prevost qui a fait apparai tre une partie de la structure hypothetico-deductive de L'Utopie; George Logan qui a mis en valeur la critique originale morienne de l'ideal politique grec et Quentin Skinner qui a demontre l'originalite d'une oeuvre inaugurant la pensee theorique politique moderne. Mais aucun de ces auteurs n'est alle jusqu'a conclure que L'Utopie exprime une philosophie a part entiere, acceptant l'hypothese qu'il s'agit d'un texte charniere entre la pensee medievale et la pensee moderne. L'enigme viendrait de la confusion due a cette dualite d'appartenance. La presente these veut demontrer que la confusion tient au lacunes des lectures du texte; que nous nous trouvons en fait devant un texte philosophique d'une haute coherence qui redefinit de maniere originale et inedite les rapports du champ de conscience et du monde; que cette revolution s'est operee en prenant appui, d'une part sur les espaces epistemologiques prepares par le debat sur le negotium et l'otium et, d'autre part, sur une synthese originale de la philosophie d'Epicure et du dogme chretien; que Thomas More a cree, ce faisant, de nouveaux outils epistemologiques, utilisant un raisonnement hypothetico-deductif sans faille; que les procedes rhetoriques, notamment la litote et la metaphore font partie de la demonstration; enfin, que la dissolution de l'ontologie fixiste au profit d'une logique du movement fonde directement l'utilitarisme moderne passant outre le "je" universel cartesien. Nous avons donc reconstitue le processus du discours de la L'Utopie en decrivant tout d'abord l'interaction de ses conditions d'intelligibilite, des demandes pratiques et des experimentations epistemologiques de la Renaissance. Nous avons effectue ensuite une analyse serree du texte afin d'en degager les contenus auxquels nous avons donne sens en devoilant la logique "cachee" de L'Utopie. Cette recherche devrait permettre de developper une theorie de la modernite a partir d'une relecture de la Renaissance. Elle devrait conduire egalement a une lecture comparative renouvelee de L'Utopie et des oeuvres de Machiavel, Bodin, Hobbes et Descarte.
title: Long-term Clinical Outcome of Anti-TNF Treatment in patients with Early Axial Spondyloarthritis: 10-year Data of the Etanercept vs. Sulfasalazin in Early Axial Spondyloarthritis Trial
Creators: name: Proft, Fabian
name: Torgutalp, Murat
name: Weiß, Anja
name: Protopopov, Mikhail
name: Rios Rodriguez, Valeria
name: Haibel, Hiltrun
name: Behmer, Olaf
name: Sieper, Joachim
name: Poddubnyy, Denis
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: Long-term data on anti-TNF treatment in patients with early axial spondyloarthritis (SpA) is scarce. The objective of this analysis was to assess the long-term clinical efficacy (up to 10 years of treatment) of a tumor necrosis factor (TNF) inhibitor etanercept (ETN) in patients with early[for full text, please go to the a.m. URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Hub distribution of the brain functional networks of newborns prenatally exposed to maternal depression and SSRI anti-depressant
Creators: name: Rotem‐Kohavi, Naama
name: Williams, Lynne J.
name: Muller, Angela M.
name: Abdi, Hervé
name: Virji-Babul, Naznin
name: Bjornson, Bruce H.
name: Brain, Ursula
name: Werker, Janet Feldman, 1951-
name: Grunau, Ruth E.
name: Miller, Steven P.
name: Oberlander, Tim F.
Publisher: name: Wiley
Year: 2020

description: Background : Prenatal maternal depression (PMD) and Selective Serotonin Reuptake Inhibitor (SSRI) antidepressants are associated with increased developmental risk in infants. Reports suggest that PMD is associated with hyperconnectivity of the insula and the amygdala, while SSRI-exposure is associated with hyperconnectivity of the auditory network in the infant brain. However, associations between functional brain organization and PMD and/or SSRI exposure are not well understood. Methods : We examined the relation between PMD or SSRI exposure and neonatal brain functional organization. Infants of control (n = 17), depressed SSRI-treated (n = 20) and depressed-only (HAM-D ≥ 8) (n = 16) women, underwent resting-state (rs)-fMRI at postnatal day 6. At 6 months temperament was assessed using infant behavioral questionnaire (IBQ). We applied GTA and partial least square regression (PLSR) to the resting-state time-series to assess group differences in modularity, and connector and provincial hubs. Results : Modularity was similar across all groups. The depressed-only group showed higher connector hub values in the left anterior-cingulate, insula, and caudate as well as higher provincial hub values in the amygdala compared to the control group. The SSRI group showed higher provincial hub values in Heschl’s gyrus relative to the depressed-only group. PLSR showed that newborns’ hub values predicted 10% of the variability in infant temperament at 6 months, suggesting different developmental patterns between groups. Conclusions : Prenatal exposures to maternal depression and SSRIs have differential impacts on neonatal functional brain organization. Hub values at 6 days predict variance in temperament between infant groups at 6 months of age.
title: Poseidon American Society of Civil Engineers/Master Builders Rocky Mountain Regional Concrete Canoe Competition
Creators: name: Guthrie, William Spencer
Publisher: name: Utah State University
Year: 1998

description: The concrete canoe team has been selected in behalf of the Utah State University Student Chapter of the American Society of Civil Engineers to prepare an entry for the 1998 ASCE Rocky Mountain Regional Concrete Canoe Competition. This event is co-sponsored by the American Society of Civil Engineers and Master Builders, Inc., and has become a tradition at annual ASCE regional conferences nationwide.
title: Clinical course of early axial spondyloarthritis over ten years: long-term results from the German Spondyloarthritis Inception Cohort
Creators: name: Poddubnyy, Denis
name: Rios Rodriguez, Valeria
name: Torgutalp, Murat
name: Verba, Maryna
name: Callhoff, Johanna
name: Protopopov, Mikhail
name: Proft, Fabian
name: Rademacher, Judith
name: Haibel, Hiltrun
name: Sieper, Joachim
name: Rudwaleit, Martin
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: Previous studies showed that patients with non-radiographic and radiographic axial spondyloarthritis (nr- and r-axSpA) have similar disease burden and similar response to anti-inflammatory therapy given similar level of inflammatory activity. Only little is known, however, about long-term[for full text, please go to the a.m. URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)