Η επίδραση της δοκιμασίας ψυχρού ύδατος στη λειτουργικότητα της αορτής σε υπερτασικούς ασθενείς
Creators: name: Σταυράτη, Αλεξία Α.
Publisher: name: Aristotle University of Thessaloniki
Year: 2005
Subjects: Ταχύτητα σφυγμικού κύματος
Δοκιμασία ψυχρού ύδατος
Κουιναπρίλη
Αμλοδιπίνη
Ατενολόλη
Pulse wave velocity
Cold pressor test
Quinapril
Amlodipine
Atenolol

description: Σκοπός της διατριβής ήταν η μελέτη της επίδρασης της δοκιμασίας ψυχρού ύδατος στη λειτουργικότητα της αορτής σε υπερτασικού ασθενείς, πριν και μετά τη χορήγηση φαρμακευτικής αγωγής και συγκεκριμένα κουιναπρίλης(ΚΟΥΙΝ), αμλοδιπίνης(ΑΜΛ) και ατενολόλης(ΑΤΕΝ). Μελετήθηκαν είκοσι(20) ασθενείς με ήπια ή μέτρια αρτηριακή υπέρταση(ΑΥ), μέσης ηλικίας 58+-8 έτη, πριν και μετά τη χορήγηση για ένα μήνα ΚΟΥΙΝ, ΑΜΛ και ΑΤΕΝ. Επίσης μελετήθηκαν δέκα(10) υγιή άτομα παρόμοιας ηλικίας που αποτέλεσαν την ομάδα ελέγχου(Ο.Ε). Μετρήθηκαν η συστολική και διαστολική αρτηριακή πίεση(ΣΑΠ, ΔΑΠ) και η ταχύτητα σφυγμικού κύματος της αορτής, σε ηρεμία και σε ΔΨΥ. Η ΤΣΚ ήταν αυξημένη στους υπερτασικούς και μειώθηκε εξίσου και με τα τρία σκευάσματα. Η ΤΣΚ παρέμεινε αμετάβλητη με τα ΔΨΥ στην ΟΕ, μειώθηκε στους υπερτασικούς πριν την αγωγή και δεν μεταβλήθηκε μετά την αγωγή
description: The aim of the present study is to evaluate the effects of Cold Pressor Test (CPT), HandGrip Isometric Exercise (HG) and combination of both interventions (COMB), on elastic properties of aorta in hypertensive patients before and after treatment with Angiotensin Converting Enzyme Inhibitors, Calcium Channel Blockers and Beta Blockers. We studied twenty (20) patients, ten (10) males and ten (10) females, mean age 58±8 years, with mild or moderate essential arterial hypertension and ten (10) healthy subjects of the same age, without arterial hypertension (control group). Pulse Wave Velocity (PWV, Sphygmocor System) of aorta was measured in all patients and in control group before and after CPT, HG and COMB. In hypertensive patients all measurements were performed before and after treatment for one month with Quinapril, Amlodipine and Atenolol. Patients with arterial hypertension had greater PWV of aorta before treatment compared to control group (11,31 vs 9,11 m/sec). PWV was positively correlated with age both in hypertensive and in normotensive patients, In hypertensive patients. PWV was also correlated positively with the level of systolic blood pressure. In hypertensive patients, antihypertensive treatment decreased PWV of aorta, but still remained greater than PWV of normotensive subjects. The alterations of PWV in hypertensive patients were the same with the three drugs (quinapril, amlodipine, atenolol). After treatment we demonstrated a positive correlation of PWV of aorta with age but not with level of systolic blood pressure in hypertensive patients. In the control group PWV of aorta was increased with HG and Comb but remained unchanged with CPT. The systolic, diastolic and mean blood pressures increased equally with all interventions. In hypertensive patients, before treatment, HG and COMB did not change PWV of aorta, although CPT decreased PWV. The systolic, diastolic and mean blood pressures increased equally with all interventions. In hypertensive patients, alterations of PWV of aorta were the same with all drugs (quinapril, amlodipine, atenolol). PWV did not change with HG, CPT or COMB. This means that the PWV decreased with CPT before treatment and remained unchanged after treatment. The systolic, diastolic and mean blood pressures increased almost equally with all interventions. Conclusions 1. Pulse Wave Velocity (PWV) of aorta is greater in hypertensive patients without treatment compared with normotensive subjects of the same age, and is positively carrelated with age and levels of systolic blood pressure. 2. Pulse Wave Velocity (PWV) of aorta in hypertensive patients, is decreased almost to the same degree after treatment with quinapriof normotensive subjects of same age. 3. The Cold Pressor Test does not change the Pulse Wave Velocity (PWV) of aorta in normotensive subjects and decreases PWV in hypertensive patients without treatment. After treatment for one month with quinapril, amlodipine or atenolol, the CPT does not change PWV of aorta, as in normotensive subjectsl, amlodipine or atenolol for one month, but still remains greater than PWV