cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
BIOLOGICAL ACTIVITY OF SOME NATURAL AND SYNTHETIC N6-SUBSTITUTED ADENOSINE DERIVATIVES (CYTOKININ RIBOSIDES)
Creators: name: BRIZZOLARI, ANDREA
Publisher: name: Universit� degli Studi di Milano
Year: 2015

description: In this Ph.D project, some natural N6 ? substituted adenosine derivatives, cytokinin ribosides (CKRs) have been investigated with the aim to draw a profile of their biological activity. CKRs belong to a class of plant hormones playing various roles in many aspects of plant development. We chose the most representative among natural cytokinin ribosides, namely N6 ? isopentenyl adenosine (iPAdo), kinetin riboside (KR), N6-benzyl adenosine (BA) and its hydroxylated derivative, ?- topolin riboside (p-TR). In the first part of the thesis, the platelet anti aggregation activity CKRs has been evaluated in vitro as inhibitors of platelet aggregation. The activity has been interpreted by in silico docking experiments as due to interaction of CKRs with P2Y12 receptor. ? -Topolin riboside showed the best platelet anti aggregation activity and in silico interaction with P2Y12 receptor, followed by N6 ? benzyladenosine. Some synthetic N6 ? substituted adenosine derivatives have been synthesized and investigated as antagonists toward the human adenosine receptors A1, A2A, A2B, A3. p-TR again was the best antagonist of A2A and A2B adenosine receptors, both involved in the platelet aggregation mechanism. Synthetic N6 ? substituted adenosine derivatives were antagonists of A3 adenosine receptor much stronger than natural CKRs. In a structure-activity study, the cytotoxic activity of natural CKRs and the synthetic analogues of p-TR were evaluated on 661W and Neuro2A cell lines trough Trypan blue and Tunel assays. Synthetic N6 ? substituted adenosine derivatives showed a cytotoxic activity stronger than p-TR itself, that, in turn, exhibited the best apoptotic property. Many biological activities shown by the CKRs examined in this thesis could be related to an effect of these compounds on the cellular oxidative stress. Thus, as a part of the PhD project, the antioxidant profile of natural and synthetic CKRs has been investigated using the most common antioxidant tests in vitro. The heterogeneity of the results suggests in some instance a possible structure ? activity relationship. However, since not all the compounds are active in every antioxidant assay, further characterization of the antioxidant profile of CKRs seems desirable, including suitable cellular assays.
Givental J-functions, Quantum integrable systems, AGT relation with surface operator
Creators: name: Nawata, Satoshi
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Algebraic Geometry (math.AG)
subject: Representation Theory (math.RT)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: We study 4d $\mathcal{N}=2$ gauge theories with a co-dimension two full surface operator, which exhibit a fascinating interplay of supersymmetric gauge theories, equivariant Gromov-Witten theory and geometric representation theory. For pure Yang-Mills and $\mathcal{N}=2^*$ theory, we describe a full surface operator as the 4d gauge theory coupled to a 2d $\mathcal{N}=(2,2)$ gauge theory. By supersymmetric localizations, we present the exact partition functions of both 4d and 2d theories which satisfy integrable equations. In addition, the form of the structure constants with a semi-degenerate field in SL(N,R) WZNW model is predicted from one-loop determinants of 4d gauge theories with a full surface operator via the AGT relation.
description: 45 pages, 6 figures, 1 table; result in Appendix A has been obtained with Antonio Sciarappa and Junya Yagi; v2, v3, v4 minor corrections and reference added
On the blockage problem and the non-analyticity of the current for the parallel TASEP on a ring
Creators: name: Scoppola, Benedetto
name: Lancia, Carlo
name: Mariani, Riccardo
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mathematical Physics (math-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Cellular Automata and Lattice Gases (nlin.CG)
subject: FOS: Physical sciences
subject: 60J10, 37B15, 60K30

description: The Totally Asymmetric Simple Exclusion Process (TASEP) is an important example of a particle system driven by an irreversible Markov chain. In this paper we give a simple yet rigorous derivation of the chain stationary measure in the case of parallel updating rule. In this parallel framework we then consider the blockage problem (aka slow bond problem). We find the exact expression of the current for an arbitrary blockage intensity $\varepsilon$ in the case of the so-called rule-184 cellular automaton, i.e. a parallel TASEP where at each step all particles free-to-move are actually moved. Finally, we investigate through numerical experiments the conjecture that for parallel updates other than rule-184 the current may be non-analytic in the blockage intensity around the value $\varepsilon = 0$.
Gravitational waves from cosmic bubble collisions
Creators: name: Kim, Dong-Hoon
name: Lee, Bum-Hoon
name: Lee, Wonwoo
name: Yang, Jongmann
name: Yeom, Dong-han
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Cosmic bubbles are nucleated through the quantum tunneling process. After nucleation they would expand and undergo collisions with each other. In this paper, we focus in particular on collisions of two equal-sized bubbles and compute gravitational waves emitted from the collisions. First, we study the mechanism of the collisions by means of a real scalar field and its quartic potential. Then, using this model, we compute gravitational waves from the collisions in a straightforward manner. In the quadrupole approximation, time-domain gravitational waveforms are directly obtained by integrating the energy-momentum tensors over the volume of the wave sources, where the energy-momentum tensors are expressed in terms of the scalar field, the local geometry and the potential. We present gravitational waveforms emitted during (i) the initial-to-intermediate stage of strong collisions and (ii) the final stage of weak collisions: the former is obtained numerically, in \textit{full General Relativity} and the latter analytically, in the flat spacetime approximation. We gain qualitative insights into the time-domain gravitational waveforms from bubble collisions: during (i), the waveforms show the non-linearity of the collisions, characterized by a modulating frequency and cusp-like bumps, whereas during (ii), the waveforms exhibit the linearity of the collisions, featured by smooth monochromatic oscillations.
description: 17 pages, 5 figures
Effect of comorbidity on risk of venous thromboembolism in patients with renal cell carcinoma
Creators: name: Nielsen, Matthew E.
name: Baron, John A.
name: Sørensen, Henrik T.
name: Lash, Timothy L.
name: Horvath-Puhó, Erzsébet
name: Smith, Angela B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: AbstractPurposeVenous thromboembolism (VTE) is associated with renal cell carcinoma (RCC), but data on the effect of comorbidities are limited. Therefore, our purpose was to determine the effect of comorbidity on VTE risk among patients with RCC.Materials and methodsA population-based cohort of all patients with RCC (n = 8,633) diagnosed in Denmark between 1995 and 2010 and a comparison cohort selected from the general population and matched on age, sex, and comorbidities (n = 83,055) were identified. Risk of subsequent VTE was estimated with 95% CI for the first 3 months, 1 year, and 5 years following cancer diagnosis. We stratified by Charlson comorbidity index (CCI) scores to estimate excess risk in patients with RCC vs. the comparison cohort within comorbidity strata. We also performed subanalyses for postoperative VTE and metastases.ResultsVTE risk was higher in the RCC compared with comparison cohort, particularly during the initial year following diagnosis (risk difference=9.9 per 1,000 persons [95% CI: 7.7–12.2]). After stratifying by CCI, excess risk declined with increasing comorbidities. The risk difference was 12.3 per 1,000 persons (95% CI: 9.1–15.5) for CCI=0 and 0.5 (95% CI: 6.0–7.0) for CCI=4. Excess risk also declined with increasing comorbidities among patients with postoperative VTE and among those with metastases.ConclusionsRCC is associated with increased risk of VTE when compared with a matched general population cohort. Risk did not appear to increase with added comorbidity burden. Clinical attention to VTE risk in patients with RCC is appropriate regardless of the presence or absence of comorbidities.
Micropapillary bladder cancer: Current treatment patterns and review of the literature
Creators: name: Grubb, Robert L.
name: Droller, Michael J.
name: Hoffman, Vanessa A.
name: McConkey, David J.
name: Dinney, Colin P.
name: Willis, Daniel L.
name: Messing, Edward
name: Milowsky, Matthew I.
name: Hansel, Donna E.
name: Kamat, Ashish M.
name: Plimack, Elizabeth R.
name: Flaig, Thomas W.
name: Koppie, Theresa M.
name: Al-Ahmadie, Hikmat A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: No guidelines exist for management of micropapillary bladder cancer (MPBC) and the majority of reports of this variant of urothelial carcinoma (UC) are case series comprised of small numbers of patients. We sought to determine current practice patterns for MPBC using a survey sent to the Society of Urologic Oncology (SUO) and to present those results in the setting of a comprehensive review of the existing literature.
Roadmap for the development of the University of North Carolina at Chapel Hill Genitourinary OncoLogy Database—UNC GOLD
Creators: name: Godley, Paul A.
name: Nielsen, Matthew E.
name: Pruthi, Raj S.
name: Wallen, Eric M.
name: You, Chaochen
name: Gallagher, Sarah A.
name: Woods, Michael E.
name: Kim, William Y.
name: Raynor, Mathew
name: Potter, Clarence W.
name: Barocas, Daniel A.
name: Milowsky, Matthew I.
name: Matthews, Jonathan E.
name: Chen, Ronald C.
name: Wang, Andrew
name: Smith, Angela B.
name: Whang, Young E.
name: Kimryn Rathmell, W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The management of genitourinary malignancies requires a multidisciplinary care team composed of urologists, medical oncologists and radiation oncologists. A genitourinary (GU) oncology clinical database is an invaluable resource for patient care and research. Although electronic medical records provide a single web-based record used for clinical care, billing and scheduling, information is typically stored in a discipline-specific manner and data extraction is often not applicable to a research setting. A GU oncology database may be used for the development of multidisciplinary treatment plans, analysis of disease-specific practice patterns, and identification of patients for research studies. Despite the potential utility, there are many important considerations that must be addressed when developing and implementing a discipline-specific database.
title: Einfluss von Kohlenhydratsupplementation unter Belastung auf Parameter des Immunsystems
Creators: name: Riebenbauer, Carola
Year: 2022

description: Infektionen nach intensiven Ausdauerbelastungen sind im Sport weit verbreitet. Diverse Immunparameter werden aus ihrem Gleichgewicht gelenkt und führen zu einem erhöhten Erkrankungsrisiko. Dadurch haben Sportler*innen mit negativen Effekten wie dem Verlust von Trainingszeit und Leistungsfähigkeit zu rechnen. Auf Grund dessen haben sich mehrere Ernährungsstrategien entwickelt, die zu einer Aufrechterhaltung eines gesunden Immunsystems führen sollen. Die vielversprechendste Variante scheint die der Kohlenhydratsupplementation zu sein. Ziel des vorliegenden systematischen Reviews war es, einen Überblick über die Auswirkungen der Kohlenhydratsupplementation vor, während und nach der Belastung auf das Immunsystem zu gewinnen. Anhand der PRISMA-Richtlinien wurden die zwei Datenbanken „PubMed“ und „Web of Science“ online nach passendenden Studien durchsucht. Die 355 gefundenen Studien reduzierten sich am Ende des Analysierungsprozesses auf elf Studien. Auf Grund der heterogenen Flüssigkeits- und Kohlenhydratmenge, sowie der unterschiedlichen Intensitätsvorgaben kam es zu teils variierenden Ergebnissen. Es zeigte sich allerdings, dass in den Kohlenhydrat-Gruppen die Auswirkungen der Ausdauerbelastung bei nahezu allen gemessenen Immunparametern abgeschwächt waren. Für zukünftige Studien wäre vor allem die tatsächliche Infektentwicklung ein interessanter Parameter. Auch die Durchführung der Studien in nicht nüchternem Zustand, sowie bei weiblichen Studienteilnehmerinnen könnte von Bedeutung sein.
description: Infections after prolonged exercise are common in endurance sports. Various immune parameters are deflected from homeostasis and results in a greater risk of infection. Consequently, athletes must deal with negative effects like loss of training time and decline in sports performance. Because of this, there are several nutritional strategies to maintain a healthy immune system during exercise. The most promising option seems to be carbohydrate supplementation. The aim of this systematic review was to provide an overview of the effects of carbohydrate supplementation before, during and after exercise on the immune system. Based on the PRSIMA statement two online databases (i.e., “PubMed” and “Web of Science”) were searched for compatible studies. The 355 studies found were reduced to eleven papers at the end of the analysis process. Due to the heterogenous amount of liquid and carbohydrates, as well as the different intensity applying during exercise trails, the results somehow varied. However, it turned out, that in the carbohydrate groups the effects of prolonged exercise on the immune system were attenuated for almost all immune related parameters. For further research, the actual development of infection would be an interesting parameter. Conducting the studies in the non-fasting state and with female participants could also be of scientific importance.
Neoadjuvant chemotherapy administration and time to cystectomy for muscle-invasive bladder cancer: An evaluation of transitions between academic and community settings
Creators: name: Smith, Angela B.
name: Rose, Tracy L.
name: Chen, Ronald C.
name: Wallen, Eric M.
name: Nielsen, Matthew E.
name: Woods, Michael E.
name: Godley, Paul A.
name: Milowsky, Matthew I.
name: Basch, Ethan
name: Pruthi, Raj S.
name: Deal, Allison M.
name: Rathmell, W. Kimryn
name: Whang, Young E.
name: Wang, Andrew
name: Dunn, Mary W.
name: Kim, William Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Neoadjuvant chemotherapy (NAC) before radical cystectomy is the standard of care for muscle-invasive bladder cancer (MIBC). Many patients are referred to an academic medical center (AMC) for cystectomy but receive NAC in the community setting. This study examines if administration of NAC in the community is associated with differences in type of NAC received, pathologic response rate (pT0), and time to cystectomy as compared to NAC administered at an AMC.
Surface water quality in canals in An Giang province, Viet Nam, from 2009 to 2016
Creators: name: Ly, Nguyen Hong Thao
name: Giao, Nguyen Thanh
Publisher: name: Journal of Vietnamese Environment
Year: 2018

description: The present study evaluates the surface water quality in the canals of An Giang province in the period from 2009 to 2016. The results showed that surface water of the canals was contaminated by organic matter and microorganisms which makes it not suitable for water supply and conservation of aquatic life. The water quality parameters such as dissolved oxygen (DO), biological oxygen demand (BOD), total suspended solids (TSS), orthophosphate (P-PO43-) and coliforms levels in the wet season were found to be higher than those in the dry season. The problem of organic and microorganic pollution over a long period of time without solutions leads to declines in water quality and then quantity as well. Agriculture is the main activity contributing to pollution of surface water in interior canals along with the activities of daily life, industry and services. This causes pollution of the surface water on Hau River due to its exchange of water with the connected canals. Good agricultural practices should be implemented to limit the pollution of surface water resources of the Mekong Delta. Nghiên cứu này nhằm đánh giá diễn biến chất lượng nước mặt trong các kênh rạch nội đồng của tỉnh An Giang trong giai đoạn 2009 – 2016. Kết quả cho thấy nước mặt tại các kênh rạch nội đồng đã ô nhiễm hữu cơ và vi sinh vật. Nguồn nước không phù hợp cho mục đích cấp nước sinh hoạt và bảo tồn thực vật thủy sinh. Các chỉ tiêu như hàm lượng oxy hòa tan (DO), nhu cầu oxy sinh hóa (BOD), tổng chất rắn lơ lửng (TSS), orthophosphate (P-PO43-) và coliforms trong mùa mưa cao hơn mùa khô. Vấn đề ô nhiễm hữu cơ và vi sinh vật diễn ra trong thời gian dài và chưa có giải pháp xử lý làm cho chất lượng nước suy giảm dẫn đến suy giảm về trữ lượng. Nông nghiệp là hoạt động chính góp phần làm ô nhiễm nguồn nước mặt trong các kênh rạch nội đồng bên cạnh các hoạt động sinh hoạt, công nghiệp và dịch vụ. Điều này dẫn đến nước mặt trên sông Hậu cũng có đặt tính ô nhiễm tương tự do trao đổi nước với các kênh rạch nội đồng. Thực hành sản xuất nông nghiệp thân thiện môi trường cần sớm được triển khai để hạn chế ô nhiễm nguồn nước mặt quan trọng của khu vực đồng bằng sông Cửu Long.
description: Journal of Vietnamese Environment, Vol 10 No 2 (2018)
Motion Corrected Cadence CPS Ultrasound for Quantifying Response to Vasoactive Drugs in a Rat Kidney Model
Creators: name: Hu, Xiaowen
name: Guracar, Ismayil M.
name: Ferrara, Katherine W.
name: Watson, Katherine D.
name: Pollard, Rachel E.
name: Dayton, Paul A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: To establish the ability of contrast enhanced motion corrected Cadence Pulse Sequencing (CPS) to detect changes in renal blood flow induced by vasoactive substances in rats.
At the Gates: The Tantalum-Rich Phase Hf3Ta2O11 and its Commensurately Modulated Structure
Creators: name: Wiedemann, Dennis
name: Lüdtke, Tobias
name: Palatinus, Lukáš
name: Willinger, Elena
name: Willinger, Marc G.
name: Mühlbauer, Martin J.
name: Lerch, Martin
Publisher: name: Technische Universität Berlin
Year: 2018
Subjects: subject: 540 Chemie und zugeordnete Wissenschaften
subject: hafnium tantalum oxide
subject: synthesis
subject: Hf3Ta2O11
subject: Pechini route

description: Generic mixtures in the system (Zr,Hf)O2–(Nb,Ta)2O5 are employed as tunable gate materials for field-effect transistors. Whereas production processes and target compositions are well-defined, resulting crystal structures are vastly unexplored. In this study, we summarize the sparse reported findings and present the new phase Hf3Ta2O11 as synthesized via a sol–gel route. Its commensurately modulated structure represents the hitherto unknown, metal(V)-richest member of the family (Zr,Hf)x(Nb,Ta)2O2x+5. Based on electron, neutron, and X-ray diffraction, the crystal structure is described within modern superspace [Hf1.2Ta0.8O4.4, Z = 2, a = 4.7834(13), b = 5.1782(17), c = 5.064(3) Å, q = 1/5c*, orthorhombic, superspace group Xmcm(00γ)s00] and supercell formalisms [Hf3Ta2O11, Z = 4, a = 4.7834(13), b = 5.1782(17), c = 25.320(13) Å, orthorhombic, space group Pbnm]. Transmission electron microscopy shows the microscopic structure from film-like aggregates down to atomic resolution. Cation ordering within the different available coordination environments is possible, but no significant hint at it is found within the limits of standard diffraction techniques. Hf3Ta2O11 is an unpredicted compound in the above-mentioned oxide systems, in which stability ranges have been disputably fuzzy and established only by syntheses via solid-state routes so far.
title: La vita delle idee. L’eredità di Edith Stein tra storia e fenomenologia
Creators: name: Verducci , Daniela
Publisher: name: Roma Tre-Press
Year: 2010

description: La riflessione che svolgo in questo saggio sviluppa un percorso aperto dalla recente rivisitazione del pensiero di Edith Stein, proposta a meno di un secolo dalla sua formulazione originaria e dalla sua prima diffusione nel volume Il percorso intellettuale di Edith Stein. Un sentiero che consente di mettere alla prova, nella sua capacità di instaurare un approccio vivo alla storia delle idee, il metodo d'indagine praticato nell'ambito della scuola fenomenologica romana, ovvero della «comunità umana e intellettuale che si è formata nel corso del tempo intorno alla figura di Edith Stein».

description: B@belonline vol. 8 Musica e Bildung. Saper suonare e imparare ad ascoltare
FEPROC Blade Model Verification - 3D Shell and Beam Model
Creators: name: Rosemeier, Malo
Publisher: name: Zenodo
Year: 2018
Subjects: Finite Element Model
Wind turbine rotor blade
Verification
ANSYS APDL

description: The verification of a finite element model implementation of the DTU10MW wind turbine blade as a 3D shell and beam model is summarized. The in-house ANSYS Parametric Design Language toolbox FEPROC (Finite Element ProCedures) and BECAS (Beam Cross Section Analysis Software) were used to create the models. The FUSED-Wind blade parametrization together with PGL (Parametric Geometry Library) were used for the blade planform and layup definition. The shell model was benchmarked with a solid model implemented in MSC Patran/Marc. While the modal and linear static responses agreed well, a discrepancy was found in the linear buckling response. The discrepancy was explained with the help of an analytical plate model. The beam model was benchmarked with the in-house anisotropic beam implementation ABeam, HAWC2 and BeamDyn showing good agreement. The dataset of the 3D shell and beam model is available at http://doi.org/10.5281/zenodo.1494044.
Global stability for the prion equation with general incidence
Creators: name: Gabriel, Pierre
Publisher: name: arXiv
Year: 2014
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: We consider the so-called prion equation with the general incidence term introduced in [Greer et al., 2007], and we investigate the stability of the steady states. The method is based on the reduction technique introduced in [Gabriel, 2012]. The argument combines a recent spectral gap result for the growth-fragmentation equation in weighted $L^1$ spaces and the analysis of a nonlinear system of three ordinary differential equations.
Quasisymmetric spheres over Jordan domains
Creators: name: Vellis, Vyron
name: Wu, Jang-Mei
Publisher: name: arXiv
Year: 2014
Subjects: subject: Metric Geometry (math.MG)
subject: FOS: Mathematics

description: Let $Ω$ be a planar Jordan domain. We consider double-dome-like surfaces $Σ$ defined by graphs of functions of $dist( \cdot ,\partial Ω)$ over $Ω$. The goal is to find the right conditions on the geometry of the base $Ω$ and the growth of the height so that $Σ$ is a quasisphere, or quasisymmetric to $\mathbb{S}^2$. An internal uniform chord-arc condition on the constant distance sets to $\partial Ω$, coupled with a mild growth condition on the height, gives a close-to-sharp answer. Our method also produces new examples of quasispheres in $\mathbb{R}^n$, for any $n\ge 3$.
description: 26 pages, accepted in the Transactions of the American Mathematical Society
The Problem of Action at a Distance in Networks and the Emergence of Preferential Attachment from Triadic Closure
Creators: name: Kunegis, Jérôme
name: Karimi, Fariba
name: Sun, Jun
Publisher: name: arXiv
Year: 2014
Subjects: subject: Social and Information Networks (cs.SI)
subject: FOS: Computer and information sciences

description: In this paper, we characterise the notion of preferential attachment in networks as action at a distance, and argue that it can only be an emergent phenomenon -- the actual mechanism by which networks grow always being the closing of triangles. After a review of the concepts of triangle closing and preferential attachment, we present our argument, as well as a simplified model in which preferential attachment can be derived mathematically from triangle closing. Additionally, we perform experiments on synthetic graphs to demonstrate the emergence of preferential attachment in graph growth models based only on triangle closing.
description: 13 pages, three figures
Changes in Physical Activity after Sacrocolpopexy for Advanced Pelvic Organ Prolapse
Creators: name: Nygaard, Ingrid
name: Wells, Ellen
name: Brubaker, Linda
name: Wei, John
name: Handa, Victoria L.
name: Goode, Patricia
name: Borello-France, Diane
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: To describe changes in physical activity one year after sacrocolpopexy for pelvic organ prolapse.
Sudden Trust Collapse in Networked Societies
Creators: name: Batista, João da Gama
name: Bouchaud, Jean-Philippe
name: Challet, Damien
Publisher: name: arXiv
Year: 2014
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: General Finance (q-fin.GN)
subject: FOS: Physical sciences
subject: FOS: Economics and business

description: Trust is a collective, self-fulfilling phenomenon that suggests analogies with phase transitions. We introduce a stylized model for the build-up and collapse of trust in networks, which generically displays a first order transition. The basic assumption of our model is that whereas trust begets trust, panic also begets panic, in the sense that a small decrease in trust may be amplified and ultimately lead to a sudden and catastrophic drop of trust. We show, using both numerical simulations and mean-field analytic arguments, that there are extended regions of the parameter space where two equilibrium states coexist: a well-connected network where confidence is high, and a poorly connected network where confidence is low. In these coexistence regions, spontaneous jumps from the well-connected state to the poorly connected state can occur, corresponding to a sudden collapse of trust that is not caused by any major external catastrophe. In large systems, spontaneous crises are replaced by history dependence: whether the system is found in one state or in the other essentially depends on initial conditions. Finally, we document a new phase, in which agents are connected yet distrustful.
description: 15 pages, 10 figures
Refractory Idiopathic Urge Urinary Incontinence and Botulinum A Injection
Creators: name: Schaffer, Joseph
name: Brubaker, Linda
name: Wei, John
name: Menefee, Shawn
name: Mahajan, Sangeeta
name: Nygaard, Ingrid
name: Weber, Anne M.
name: Richter, Holly E.
name: Barber, Matthew D.
name: Braun, Thomas M.
name: Visco, Anthony
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: We compared 200 U intradetrusor botulinum toxin A vs placebo in women with refractory idiopathic urge incontinence.
Alphaviral vector-transduced dendritic cells are successful therapeutic vaccines against neu-overexpressing tumors in wild-type mice
Creators: name: Burgents, Joseph E.
name: Moran, Timothy P.
name: Johnston, Robert E.
name: Serody, Jonathan S.
name: Ferrer, Ivana
name: Long, Brian
name: Tisch, Roland M.
name: Jaffee, Elizabeth M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: While dendritic cell (DC) vaccines can protect hosts from tumor challenge, their ability to effectively inhibit the growth of established tumors remains indeterminate. Previously, we have shown that human DCs transduced with Venezuelan equine encephalitis virus replicon particles (VRPs) were potent stimulators of antigen-specific T cells in vitro. Therefore, we investigated the ability of VRP-transduced DCs (VRP-DCs) to induce therapeutic immunity in vivo against tumors overexpressing the neu oncoprotein. Transduction of murine DCs with VRPs resulted in high-level transgene expression, DC maturation and secretion of proinflammatory cytokines. Vaccination with VRP-transduced DCs (VRP-DCs) expressing a truncated neu oncoprotein induced robust neu-specific CD8+ T cell and anti-neu IgG responses. Furthermore, a single vaccination with VRP-DCs induced the regression of large established tumors in wild-type mice. Interestingly, depletion of CD4+, but not CD8+, T cells completely abrogated inhibition of tumor growth following vaccination. Taken together, our results demonstrate that VRP-DC vaccines induce potent immunity against established tumors, and emphasize the importance of the generation of both CD4+ T cell and B cell responses for efficient tumor inhibition. These findings provide the rationale for future evaluation VRP-DC vaccines in the clinical setting.
The feasibility of HIV vaccine efficacy trials among Russian injection drug users
Creators: name: Latkin, Carl
name: Heimer, Robert
name: Hoffman, Irving
name: Verevochkin, Sergey
name: Baral, Stefan
name: Dukhovlinova, Elena
name: Kozlov, Andrei
name: Beyrer, Chris
name: Masharsky, Alexey
name: Shaboltas, Alla
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: IDU exposure remains a primary driver of the Russian HIV epidemic, and recent incidence data provide little evidence that this epidemic is slowing. While there are multiple important challenges that need to be further explored before starting vaccine trials, most importantly access to evidence-based drug treatment services for trial participants, the current context of high HIV incidence and low genetic diversity of HIV strains, suggests the need for intensified prevention strategies and supports the feasibility of mounting efficacy trials of HIV vaccines among IDUs in the Russian Federation.
Alphavirus replicon particles acting as adjuvants promote CD8+ T cell responses to co-delivered antigen
Creators: name: Johnston, Robert E.
name: Thompson, Joseph M.
name: Whitmore, Alan C.
name: Staats, Herman F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Alphavirus replicon particles induce strong antibody and CD8+ T cell responses to expressed antigens in numerous experimental systems. We have recently demonstrated that Venezuelan equine encephalitis virus replicon particles (VRP) possess adjuvant activity for systemic and mucosal antibody responses. In this report, we demonstrate that VRP induced an increased and balanced serum IgG subtype response to co-delivered antigen, with simultaneous induction of antigen-specific IgG1 and IgG2a antibodies, and increased both systemic and mucosal antigen-specific CD8+ T cell responses, as measured by an IFN-γ ELISPOT assay. Additionally, VRP further increased antigen-specific T cell immunity in an additive fashion following co-delivery with the TLR ligand, CpG DNA. VRP infection led to recruitment of CD8+ T cells into the mucosal compartment, possibly utilizing the mucosal homing receptor, as this integrin was upregulated on CD8+ T cells in the draining lymph node of VRP-infected animals, where VRP-infected dendritic cells reside. This newly recognized ability of VRP to mediate increased T cell response towards co-delivered antigen provides the potential to both define the molecular basis of alphavirus-induced immunity, and improve alphavirus-based vaccines.
title: Filmästhetische Horizonterfahrungen
Creators: name: Boldavesko, Deniss
Year: 2022

description: Diese Arbeit beschäftigt sich mit filmästhetischen Konstellationen, welche als Verhandlungsort von Materie, Wahrnehmung und Bewegung fungieren. Deleuzes Konzept der gasförmigen Wahrnehmung und Seels Begriff des Rauschens bilden den Nährboden, um im ersten Teil dieser Arbeit von einer kritischen Gegenüberstellung dieser den Horizonten des Menschlichen zugewandten Denklinien heraus, filmästhetische Horizonterfahrungen entlang einer heterogenen Auswahl an Filmen – von Art House bis Spielfilm – zu modellieren. Der zweite Teil nutzt dieses Fundament und definiert und erarbeitet den Begriff der filmästhetischen Horizonterfahrungen. Diese agieren auf der Ebene reiner Bewegungsphänomene, sind subsinnhaft, diffus, finden vor allem in der Leere und Fülle Einkehr und nähern sich auf der temporalen Skala einer Unmittelbarkeit durch direkte Affizierung an. Es wird gezeigt, dass sich filmästhetische Horizonterfahrungen immer diametral zu narrativen Bestrebungen bewegen. Um dieser Richtung und dem materialistischen Fundament gerecht zu werden, wird von Erhitzung, also Auflösung, des Narrativen gesprochen. Somit sind diese Erfahrungen insoweit horizonthaft, als dass sie uns sprachliches Wesen Mensch, durch filmformale Operationen, Skalierungen von Materialität erfahren lassen, die uns an den Horizont der menschlichen-alltäglich-handlungsorientierten Erfahrung bringen. Im Zuge dessen sind Rückschlüsse über den materiellen Prozess von Filmwahrnehmung als solchen, als materiellen Bewegungszusammenhang erarbeitet. Filmästhetische Horizonterfahrungen sind damit das genetische Element von filmästhetischen Konstellationen als solches, da sie das nicht-menschliche Lichtspiel in den Fokus rücken. Die Erkenntnisse werden daraufhin abseits von rein filmästhetischen Konstellationen auf die ästhetischen Bewegtbilder der Virtual Reality erweitert. Es wird geprüft, inwieweit innerhalb dieser ästhetischen Konstellationen ästhetische Horizonterfahrungen möglich sind, inwieweit die medialen Bedingungen die Wahrscheinlichkeit und Intensität solcher Erfahrungen erhöhen bzw. verstärken können.
Comparison of multiple vaccine vectors in a single heterologous prime-boost trial
Creators: name: Liao, Hua Xin
name: Thornburg, Natalie J.
name: Ramsburg, Elizabeth
name: Sample, Christopher
name: Barouch, Daniel H.
name: Barefoot, Brice
name: Kepler, Thomas B.
name: Haynes, Barton F.
name: Johnston, Robert E.
name: Yu, Jae-sung
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The prevention of infectious disease via prophylactic immunization is a mainstay of global public health efforts. Vaccine design would be facilitated by a better understanding of the type and durability of immune responses generated by different vaccine vectors. We report here the results of a comparative immunogenicity trial of six different vaccine vectors expressing the same insert antigen, cowpox virus B5 (CPXV-B5). Of those vectors tested, recombinant adenovirus (rAd5) was the most immunogenic, inducing the highest titer anti-B5 antibodies and conferring protection from sublethal vaccinia virus challenge in mice after a single immunization. We tested select heterologous prime-boost combinations and identified recombinant vesicular stomatitis virus (rVSV) and recombinant Venezuelan equine encephalitis virus replicons (VRP) as the most synergistic regimen. Comparative data such as those presented here are critical to efforts to generate protective vaccines for emerging infectious diseases as well as for biothreat agents.
Gap solitons and symmetry breaking in parity-time symmetric microring CROWs
Creators: name: Chamorro-Posada, Pedro
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optics (physics.optics)
subject: Pattern Formation and Solitons (nlin.PS)
subject: FOS: Physical sciences

description: The propagation properties of optical fields in linear and nonlinear parity-time symmetric microring coupled resonator optical waveguides are studied. The effects described include the existence of symmetry breaking thresholds, the propagation of gap solitons in nonlinear transmission lines and the existence of quasi stable propagation regimes outside the broken symmetry regions.
description: Final Version
Large-$N_c$ naturalness in coupled-channel meson-meson scattering
Creators: name: Ledwig, T.
name: Nieves, J.
name: Pich, A.
name: Arriola, E. Ruiz
name: de Elvira, J. Ruiz
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The analysis of hadronic interactions with effective field theory techniques is complicated by the appearance of a large number of low-energy constants, which are usually fitted to data. On the other hand, the large-$N_c$ limit imposes natural short-distance constraints on these low-energy constants, providing a parameter reduction. A Bayesian interpretation of the expected $1/N_c$ accuracy allows for an easy and efficient implementation of these constraints, using an augmented $χ^2$. We apply this approach to the analysis of meson-meson scattering, in conjunction with chiral perturbation theory to one loop and coupled-channel unitarity, and show that it helps to largely reduce the many existing ambiguities and simultaneously provide an acceptable description of the available phase shifts.
description: 17 pages, 15 figures
The contribution of type I interferon signaling to immunity induced by alphavirus replicon vaccines
Creators: name: Thompson, Joseph M.
name: Whitmore, Alan C.
name: Staats, Herman F.
name: Johnston, Robert
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The type I interferon (IFN) system is critical for protecting the mammalian host from numerous virus infections and plays a key role in shaping the anti-viral adaptive immune response. In this report, the importance of type I IFN signaling was assessed in a mouse model of alphavirus-induced humoral immune induction. Venezuelan equine encephalitis virus replicon particles (VRP) expressing the hemagglutinin (HA) gene from influenza virus (HA-VRP) were used to vaccinate both wildtype (wt) and IFN α/β receptor knockout (RKO) mice. HA-VRP vaccination induced equivalent levels of flu-specific systemic IgG, mucosal IgG, and systemic IgA antibodies in both wt and IFN RKO mice. In contrast, HA-VRP vaccination of IFN RKO mice failed to induce significant levels of flu-specific mucosal IgA antibodies at multiple mucosal surfaces. In the VRP adjuvant system, co-delivery of null VRP with ovalbumin (OVA) protein significantly increased the levels of OVA-specific serum IgG, fecal IgG, and fecal IgA antibodies in both wt and RKO mice, suggesting that type I IFN signaling plays a less significant role in the VRP adjuvant effect. Taken together, these results suggest that, 1) at least in regard to IFN signaling, the mechanisms which regulate VRP-induced immunity differ when VRP are utilized as expression vectors as opposed to adjuvants, and 2) type I IFN signaling is required for the induction of mucosal IgA antibodies directed against VRP-expressed antigen. These results potentially shed new light on the regulatory networks which promote immune induction, and specifically mucosal immune induction, with alphavirus vaccine vectors.
How much will it hurt? HPV vaccine side effects and influence on completion of the three-dose regimen
Creators: name: Gottlieb, Sami L.
name: McRee, Annie-Laurie
name: Smith, Jennifer S.
name: Brewer, Noel T.
name: Reiter, Paul L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: We examined the prevalence of reported pain following human papillomavirus (HPV) vaccination and whether it differed from that for other adolescent vaccines or affected completion of the HPV vaccine regimen. In 2008, we conducted cross-sectional surveys with parents of adolescent girls aged 11–20 living in areas of North Carolina with elevated cervical cancer rates who had received at least one dose of HPV vaccine. Pain from HPV vaccination, while commonly reported by parents, was less frequent compared to other adolescent vaccines and did not appear to affect vaccine regimen completion. These findings may be important to increase HPV vaccination coverage.
Towards crowdsourcing and cooperation in linguistic resources
Creators: name: Ustalov, Dmitry
Publisher: name: arXiv
Year: 2014
Subjects: subject: Social and Information Networks (cs.SI)
subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences
subject: K.4.3

description: Linguistic resources can be populated with data through the use of such approaches as crowdsourcing and gamification when motivated people are involved. However, current crowdsourcing genre taxonomies lack the concept of cooperation, which is the principal element of modern video games and may potentially drive the annotators' interest. This survey on crowdsourcing taxonomies and cooperation in linguistic resources provides recommendations on using cooperation in existent genres of crowdsourcing and an evidence of the efficiency of cooperation using a popular Russian linguistic resource created through crowdsourcing as an example.
description: 11 pages, 2 figures, accepted to RuSSIR 2014, the final publication is available at link.springer.com
A systematic review of measures used in studies of human papillomavirus (HPV) vaccine acceptability
Creators: name: Tuff, Raegan A.
name: Glenn, Beth
name: Allen, Jennifer D.
name: Coronado, Gloria D.
name: Mullen, Patricia Dolan
name: Fernandez, Maria
name: Escoffery, Cam
name: Wilson, Katherine M.
name: Williams, Rebecca S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The recent proliferation of studies describing factors associated with HPV vaccine acceptability could inform health care providers in improving vaccine coverage and support future research. This review examined measures of HPV and HPV-vaccine knowledge, attitudes, beliefs and acceptability, described psychometric characteristics, and provided recommendations about their use.
Dynamical phase transition in the open Dicke model
Creators: name: Klinder, J.
name: Keßler, H.
name: Wolke, M.
name: Mathey, L.
name: Hemmerich, A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: The Dicke model with a weak dissipation channel is realized by coupling a Bose-Einstein condensate to an optical cavity with ultra-narrow bandwidth. We explore the dynamical critical properties of the Hepp-Lieb-Dicke phase transition by performing quenches across the phase boundary. We observe hysteresis in the transition between a homogeneous phase and a self-organized collective phase with an enclosed loop area showing power law scaling with respect to the quench time, which suggests an interpretation within a general framework introduced by Kibble and Zurek. The observed hysteretic dynamics is well reproduced by numerically solving the mean field equation derived from a generalized Dicke Hamiltonian. Our work promotes the understanding of nonequilibrium physics in open many-body systems with infinite range interactions.
description: 10 pages, 4 figures. Main text & Supplement; PNAS 2015. arXiv admin note: text overlap with arXiv:1407.4954
Alphavirus replicon-based enhancement of mucosal and systemic immunity is linked to the innate response generated by primary immunization
Creators: name: Tonkin, Daniel R.
name: Barro, Mario
name: Jorquera, Patricia
name: Beard, Clayton W.
name: Johnston, Robert E.
name: Todd, Tracie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Venezuelan equine encephalitis virus replicon particles (VRP) function as an effective systemic, cellular and mucosal adjuvant when codelivered with antigen, and show promise for use as a component in new and existing human vaccine formulations. We show here that VRP are effective at low dose and by intramuscular delivery, two useful features for implementation of VRP as a vaccine adjuvant. In mice receiving a prime and boost with antigen, we found that VRP are required in prime only to produce a full adjuvant effect. This outcome indicates that the events triggered during prime with VRP are sufficient to establish the nature and magnitude of the immune response to a second exposure to antigen. Events induced by VRP in the draining lymph node after prime include robust secretion of many inflammatory cytokines, upregulation of CD69 on leukocytes, and increased cellularity, with a disproportionate increase of a cell population expressing CD11c, CD11b, and F4/80. We show that antigen delivered 24 hours after administration of VRP does not benefit from an adjuvant effect, indicating that the events which are critical to VRP-mediated adjuvant activity occur within the first 24 hours. Further studies of the events induced by VRP will help elucidate the mechanism of VRP adjuvant activity and will advance the safe implementation of this adjuvant in human vaccines.
Rechenschwäche in der Sekundarstufe – ein Modellprojekt
Creators: name: Steinecke, Annalisa
Publisher: name: Gesellschaft für Didaktik der Mathematik
Year: 2023
Subjects: subject: Rechenschwäche
subject: Modellversuch
subject: Sekundarstufe
subject: Grundschule
subject: Arithmetik
subject: Heterogenität & Inklusion im MU
subject: 510

description: Etwa 5% der Grundschüler*innen haben besondere Schwierigkeiten beim Mathematiklernen, die mitunter als Rechenschwäche bezeichnet werden. Rechenschwäche entsteht, wenn Kinder in der Primarstufe keine tragfähigen Vorstellungen für natürliche Zahlen, für das dezimale Stellenwertsystem und für die Rechenoperationen mit natürlichen Zahlen aufbauen (Gaidoschick et al., 2021). Nach dem Übertritt in die weiterführende Schule sind rechenschwache Schüler* innen erheblich daran gehindert, die vielfältigen Lernziele des Mathematikunterrichts in der Sekundarstufe (z. B. zu negativen Zahlen, Brüchen, Termen oder Funktionen) zu erreichen. Durch eine spezifische Förderung zum Umgang mit natürlichen Zahlen kann diesen Schülerinnen und Schülern jedoch substanziell geholfen werden, die Rechenschwäche zu überwinden. Eine gezielte Förderung schafft also die Voraussetzungen dafür, dass die Schüler*innen in der Sekundarstufe erfolgreich sind.
Open quantum systems and Random Matrix Theory
Creators: name: Mulhall, Declan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: A simple model for open quantum systems is analyzed with Random Matrix Theory. The system is coupled to the continuum in a minimal way. In this paper we see the effect of opening the system on the level statistics, in particular the $Δ_3(L)$ statistic, width distribution and level spacing are examined as a function of the strength of this coupling. A super-radiant transition is observed, and it is seen that as it is formed, the level spacing and $Δ_3(L)$ statistic exhibit the signatures of missed levels.
description: 15 pages, 9 figures
ESTUDIO SOBRE EL ESTADO DE LA DIGITALIZACIÓN DE LOS CENTROS DE DOCUMENTACIÓN Y BIBLIOTECAS DEL SINDICATO UNIÓN GENERAL DE TRABAJADORES (UGT)
Creators: name: Zurita Jiménez, Clotilde
Publisher: name: Zenodo
Year: 2022
Subjects: Humanidades Digitales, Bibliotecas, Centros de Documentación, Archivos Historicos

description: Estudio sobre el estado actual del proceso de digitalización de la documentación existente en los Archivos Historicos, Centros de Documentación y Bibliotecas del Sindicato Unión General de Trabajadores de España.