cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Two essays on consumer consensus on perceived quality
Creators: name: Yayla, Serdar
Publisher: name: No Publisher Supplied
Year: 2018

description: The concept of consensus has been investigated by scholars from various disciplines. However, in the area of marketing, few researchers have examined the role of consensus in the consumer decision-making process. Studies devoted the consumer consensus have produced conflicting results depending on the type of product examined. To shed light on its impact on the consumer decision-making process, I will investigate consumer consensus using a dataset comprised of 1144 brands over an 11-year time period. This dissertation consists of two essays about consumer consensus on quality. In the first essay, I examine antecedents of the perceived quality discrepancy (PQD) which reflect the lack of consumer consensus on quality perceptions in a market. Moreover, the impact of PQD on brand-level sales and purchase intention scores is examined. Results indicated a negative relationship between PQD and perceived quality. Similarly, PQD has a negative impact on brand-level sales and purchase intention scores. In addition, advertising expenditures generate more revenues for brands that have higher PQD. Also, the negative impact of PQD on purchase intention is higher for the brands that have higher quality. In the second essay, I examine the impact of PQD on perceived quality by time perspective. In this study, I aim to illuminate changes in quality perceptions in response to the consensus on quality. The results indicate that on average, a change in PQD can be fully realized after 1.84 years. Moreover, the short-term effect of PQD on perceived quality is higher for service brands and higher in the hedonic product categories than in the utilitarian categories. Results also indicate that the carryover duration can take as long as 2.51 years for products, while it can take as long as 1.98 years for services.
title: From Volcanoes to Glaciers – The importance of geoscientific research during the site-selection procedure for a high-level nuclear waste repository in Germany
Creators: name:   Nilius , Nils-Peter
name:   Fink , Reinhard
name:   Reiche , Sönke
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: After implementation of the Repository Site Selection Act (StandAG) in 2017, the Federal Company for Radioactive Waste Disposal mbH (BGE mbH), as the German waste-management organization, started the site-selection procedure for a nuclear repository for high-level radioactive waste in Germany. On the way towards the repository site with the best possible safety, the site-selection procedure is required to be a participatory, transparent, learning and self-questioning process based on scientific expertise. With an Interim Report published in 2020, first results were presented, outlining sub-areas with favorable geological conditions in preparation for defining the site regions for surface exploration. The next phases of the site selection procedure will require detailed geoscientific research outcomes to improve the understanding of various geological processes. This information is a prerequisite to assess the properties of the geological barrier and to constrain future developments of the geological system, hosting the nuclear repository within the next 1 million years. Therefore, research funded by the BGE covers various geoscientific subjects, ranging from volcanism to glacial erosion and computational geosciences. With this contribution, the BGE intends to highlight some of its scientific key projects within the current step in the site-selection program. Scientific collaborators are different players including the Federal Institute for Geosciences and Natural Resources (BGR), German Universities and specialized companies with a wide range of expertise that will support the required learning, self-questioning and science-based site-selection procedure for a nuclear repository for high-level radioactive waste in Germany.
title: Episodic mantle overturn in a non-plate tectonic mantle
Creators: name:   Vesterholt ,  Anders Lillevang
name:   Nagel ,  Thorsten J.
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: Using ultra-high-resolution, 2D-thermomechanical modeling, we explore the evolution of the mantle of a terrestrial planet with a stagnant lid like Venus or the early Earth. Without plate tectonics, the mantle will heat over time from the decay of radiogenic isotopes. The convecting upper mantle will undergo partial melting and thicken a basaltic crust. When the crust reaches a critical thickness, the base of it transforms into eclogite. As eclogite is considerably denser than the underlying mantle it will ultimately delaminate. While ringwoodite in the peridotitic ambient mantle turns into perovskite and periclase at around 24 GPa and becomes about 10% denser, the similar phase reaction for garnet into perovskite in the basaltic crust occurs deeper, at around 27 GPa. The delaminated crust therefore accumulates in the 24-27 GPa range, where it has an intermediate density of the material above and below, and therefore suppresses convection across. Over time, this causes a significant temperature offset, as the upper mantle can continuously vent radiogenic heat, while the lower mantle cannot. Eventually, the crust-rich layer is pushed beyond 27 GPa and becomes denser than the underlying lower mantle. This triggers a run-away global mantle overturn. Superheated lower mantle streams upwards into the melting zone, increasing magmatic production by orders of magnitude for ≈50 Myr. After overturn, the mantle is highly heterogeneous with preserved domains of primitive mantle in a fooliated mélange of depleted mantle and basaltic crust.
Phorbol ester inhibits erythropoietin production in human hepatoma cells (Hep G2)
Creators: name: Kurtz, Armin
name: Eckardt, K. U.
name: Pugh, C.
name: Corvol, P.
name: Fabbro, D.
name: Ratcliffe, P.
Publisher: name: Universität Regensburg
Year: 1992
Subjects: subject: 570 Biowissenschaften, Biologie
subject: 610 Medizin
subject: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
subject: Alkaloids/pharmacology
subject: Carcinoma, Hepatocellular/ultrastructure
subject: Erythropoietin/genetics
subject: Humans
subject: Isoquinolines/pharmacology
subject: Liver Neoplasms/ultrastructure
subject: Oxygen/pharmacology
subject: Piperazines/pharmacology
subject: Protein Kinase C/metabolism
subject: RNA, Messenger/metabolism
subject: Staurosporine
subject: Tetradecanoylphorbol Acetate/pharmacology
subject: Tissue Distribution
subject: Tumor Cells, Cultured

description: Using the human hepatoma cell line Hep G2, we have studied a possible role of protein kinase C (PKC) activity for regulation of erythropoietin (EPO) production. During a 72-h incubation, EPO production by the cells was stimulated sevenfold by exposure to low oxygen tension (1%) and threefold by exposure to cobaltous chloride (100 microM). The phorbol ester phorbol 12-myristate-13 acetate (PMA) led to a concentration-dependent inhibition of basal and stimulated EPO formation (ED50 10 nM). This decrease of EPO production, which was apparent already after 1 h of incubation with PMA, reached its maximal effect after 24 h and held on for 72 h. It was paralleled by an inhibition of the increase of EPO mRNA levels in response to stimulation. A 24-h preincubation of the cells with PMA (100 nM) virtually blunted the effect of hypoxia on EPO formation. Recovery of EPO synthesis after removal of PMA took 48-72 h. The effect of PMA on EPO production was mimicked by phorbol 12,13-dibutyrate (ED50 1 microM) but not by 4 alpha-phorbol 12,13-didecanoate. The synthetic diacylglycerol analogues oleolyl-acetylglycerol and dioctanoylglycerol (2-200 microM) also had no effect on either basal or stimulated EPO production. Treatment with PMA caused a translocation of the alpha-isoenzyme of PKC from the cytosol to the membrane after 1 h and a disappearance of the membrane-bound form after 24 h of incubation. Staurosporine and 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine, two structurally different inhibitors of PKC activity, inhibited basal and stimulated EPO production with ED50 values of 9 nM and 50 microM, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
Optimal asymptotic cloning machines
Creators: name: Chiribella, G.
name: Yang, Y.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We pose the question whether the asymptotic equivalence between quantum cloning and quantum state estimation, valid at the single-clone level, still holds when all clones are examined globally. We conjecture that the answer is affirmative and present a large amount of evidence supporting our conjecture, developing techniques to derive optimal asymptotic cloners and proving their equivalence with estimation in virtually all scenarios considered in the literature. Our analysis covers the case of arbitrary finite sets of states, arbitrary families of coherent states, arbitrary phase- and multiphase-covariant sets of states, and two-qubit maximally entangled states. In all these examples we observe that the optimal asymptotic fidelity enjoys a universality property, as its scaling does not depend on the specific details of the set of input states, but only on the number of parameters needed to specify them.
description: 27 + 9 pages, corrected one observation about cloning of maximally entangled states
Evaluation of the Social Impact of Reservoir Construction on the Residential Plans of Displaced Persons in Kentucky and Ohio
Creators: name: Ludtke, Richard L.
name: Burdge, Rabel J.
Publisher: name: Kentucky Water Resources Research Institute, University of Kentucky
Year: 1970

description: Abstract:
The states of Kentucky and Ohio have numerous reservoir projects at various stages of planning and construction. Each of the projects produces substantial social impact for the residents of the area and particularly for those persons affected by a loss of property and homes. This impact is not uniform in that people respond differently to displacement and the methods of adjusting relocation are known to differ among people.
This research was initiated to develop and test a model for explaining migration under such conditions. The model includes a consideration of people's potential for transferring existing statuses to new residences, the extent to which peoples interests are served by the reservoir, people's knowledge of the reservoir, the social class levels of those displaced and the extent to which people identify with their places of residence. These factors are viewed as affecting people's levels of apprehension and consequently their willingness to separate from their current membership systems.
Data for this investigations come from all the adult residents of the areas to be flooded neat Taylorsville, Kentucky and Lebanon, Ohio. These areas are in the Louisville District of the U.S. Army Corps of Engineers and exhibit similar topographies with rural populations of similar socio-economic and social isolation.
The testing of this model indicated that apprehensions over money is greatest for those persons who identify strongly with their present homes. Also, apprehension over migration was less for those persons whose vested interests were served by the project. Knowledge of the reservoir project did not reduce apprehensions over moving as was predicted by the model.
Funding information: The work upon which this report is based was supported in part by funds provided by the United States Department of the Interior, Office of Water Resources Research, as authorized under the Water Resources Research Act of 1964.
Calmodulin antagonists stimulate renin secretion and inhibit renin synthesis in vitro
Creators: name: Della Bruna, R.
name: Pinet, F.
name: Corvol, P.
name: Kurtz, Armin
Publisher: name: Universität Regensburg
Year: 1992
Subjects: subject: 570 Biowissenschaften, Biologie
subject: 610 Medizin
subject: Animals
subject: Calmodulin/antagonists & inhibitors
subject: Cells, Cultured
subject: Cycloheximide/pharmacology
subject: Imidazoles/pharmacology
subject: Juxtaglomerular Apparatus/enzymology
subject: Kinetics
subject: Male
subject: Mice
subject: Mice, Inbred C57BL
subject: Protein Biosynthesis
subject: Renin/secretion
subject: Sulfonamides/pharmacology
subject: Sulfur Radioisotopes
subject: Trifluoperazine/pharmacology

description: To find out whether calmodulin activity could be a common denominator for the cellular control of renin secretion and synthesis, we have examined the effects of calmodulin antagonists on the secretion and the synthesis of renin in primary cultures of mouse juxtaglomerular (JG) cells. We found that the calmodulin antagonists calmidazolium (CMDZ), N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7), and trifluoperazine (TFP) strongly stimulated renin release from isolated JG cells with a rank order of potency CMDZ greater than TFP greater than W-7. With the same order of potency as on renin secretion, CMDZ, TFP, and W-7 also inhibited de novo synthesis of renin. This decrease of renin synthesis went in parallel with a general inhibition of protein synthesis in the cultured JG cells. A comparable inhibition of total protein synthesis and renin synthesis as with CMDZ was achieved with cycloheximide. Cycloheximide, however, did not alter renin secretion within 20 h of incubation. Taken together, our findings suggest that inhibition of calmodulin activity exerts a powerful stimulatory effect on the exocytosis of renin in renal JG cells. Calmodulin activity on the other hand is also essentially required for protein and renin synthesis in JG cells. It is not very likely therefore that calmodulin activity positively links renin synthesis and renin secretion in JG cells.
New chemical resins for SLA-based 3D printers
Creators: name: Shahzadi, L
Publisher: name: University of Tasmania
Year: 2024

description: Advances in additive manufacturing (often referred to as "3D printing" technologies have greatly simplified prototype manufacturing and complex design over the past decade. One particular class of 3D printing, namely stereolithography (SLA) and its variants, has particular appeal due to the ability to create objects with small feature sizes and high resolution. However, most commercially available SLA material components are based on (meth)acrylate-based resin systems that have several disadvantages associated with their use, such as inhibition of polymerisation by oxygen, solvent resistance, and the inability to modify surfaces post-printing. The aims of this work were to prepare new chemical resins for SLA-based 3D printers to reduce the disadvantages associated with (meth)acrylate-based commercial resins. Polymerisation via a thiol-acrylate/alkene/alkyne mechanism can help overcome many of these drawbacks, however, these systems are less studied in the context of SLA 3D printing.In this work, firstly, we report the design and optimisation of thiol-acrylate resin formulations with a view towards effectively controlling the polymerisation depth of the cured polymer layer. Four different photo-blockers were studied and the use of 1,3-bis(4-methoxyphenyl)propane-1,3-dione enabled optically transparent and colourless printed objects with good resolution to be realised. Taking advantage of ready post-printing surface modification of thiol-acrylate polymers, various hydrophilic, hydrophobic, and fluorescent polymer chains were successfully grafted to the object surface via RAFT polymerisation. Free thiol groups at the surface of offstoichiometric resin formulations were also used to immobilize gold nanoparticles for the catalytic conversion of 4-nitrophenol to 4-aminophenol. Secondly, A new 3D printable resin formulation was developed and optimised from commercially available thiol-alkyne monomers. A 3D device was designed from the resin formulation to remove malachite green (MG) from real water samples collected from tap and river, respectively. The results displayed excellent dye removal efficiency, and >95% dye was removed within 5 min. The 3D printed devices were found to be recyclable and removed 100% dye over 6 times after simple washing with de-ionized water and methanol. Thirdly, new alkyne-based monomers were synthesised in house and optimised to prepare formulations for SLA printing. The prepared materials exhibited better solvent resistance and mechanical properties compared to the acrylate-based formulations. The free alkyne surface groups were utilised for post-print alkyne-azide click polymerisation. The successful development of these resins has resulted in novel systems for stereolithography (SLA) 3D printing. The easily tuneable resin composition and post-print surface modifications make them an attractive candidate for SLA printers as well as hold immense potential for broad commercial applications.
Free integro-differential algebras and Gröbner-Shirshov bases
Creators: name: Gao, Xing
name: Guo, Li
name: Rosenkranz, Markus
Publisher: name: arXiv
Year: 2014
Subjects: subject: Rings and Algebras (math.RA)
subject: FOS: Mathematics
subject: 16S15, 13P10, 16W99, 17A50

description: The notion of commutative integro-differential algebra was introduced for the algebraic study of boundary problems for linear ordinary differential equations. Its noncommutative analog achieves a similar purpose for linear systems of such equations. In both cases, free objects are crucial for analyzing the underlying algebraic structures, e.g. of the (matrix) functions. In this paper we apply the method of Gröbner-Shirshov bases to construct the free (noncommutative) integro-differential algebra on a set. The construction is from the free Rota-Baxter algebra on the free differential algebra on the set modulo the differential Rota-Baxter ideal generated by the noncommutative integration by parts formula. In order to obtain a canonical basis for this quotient, we first reduce to the case when the set is finite. Then in order to obtain the monomial order needed for the Composition-Diamond Lemma, we consider the free Rota-Baxter algebra on the truncated free differential algebra. A Composition-Diamond Lemma is proved in this context, and a Gröbner-Shirshov basis is found for the corresponding differential Rota-Baxter ideal.
description: Journal of Algebra (to appear 2015)
Disparate effects of calcium channel blockers on pressure dependence of renin secretion and flow in the isolated perfused rat kidney
Creators: name: Scholz, Holger
name: Kurtz, Armin
Publisher: name: Universität Regensburg
Year: 1992
Subjects: subject: 570 Biowissenschaften, Biologie
subject: 610 Medizin
subject: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester/pharmacology
subject: Animals
subject: Bumetanide/pharmacology
subject: Calcium Channel Blockers/pharmacology
subject: Glomerular Filtration Rate/drug effects
subject: Isoproterenol/pharmacology
subject: Kidney/metabolism
subject: Nifedipine/pharmacology
subject: Potassium/metabolism
subject: Rats
subject: Rats, Inbred Strains
subject: Renin/secretion
subject: Sodium/metabolism
subject: Verapamil/pharmacology

description: Using the model of isolated perfused rat kidneys this study was performed to investigate whether or not voltage-operated calcium channels are essentially involved in the pressure control of renin secretion from the kidneys. At a perfusion pressure of 100 mm Hg (13.3 kPa) renin secretory rates were 4.2 +/- 0.7 (ng angiotensin I h-1) min-1 g-1. Stepwise reduction of renal perfusion pressure to 80, 60, and 40 mm Hg (10.6, 8.0, 5.3 kPa) resulted in an increase of renin release yielding a 30-fold stimulation at 40 mm Hg vs 100 mm Hg. Increasing the perfusion pressure above 100 mm Hg did not further significantly decrease renin secretion. The perfusate flow rate was also pressure-dependent. Flow rates increased linearly with pressure and reached a plateau at 100 mm Hg, which was maintained up to 160 mm Hg (21.3 kPa). The averaged flow rate at the plateau was 15.5 ml min-1 g-1. In the presence of the three different calcium antagonists nifedipine (5 microM), nitrendipine (3 microM) and verapamil (5 microM), myogenic autoregulation of flow was abolished as indicated by the rise of the pressure/flow curve between 40 and 160 mm Hg. At the same time, however, these calcium channel blockers did not alter the relationship between perfusion pressure and renin secretion. Moreover, the calcium channel agonist Bay K 8644 (5 microM) caused a strong and long-lasting vasoconstriction, without changing renin secretion.(ABSTRACT TRUNCATED AT 250 WORDS)
Sharp norm estimates of layer potentials and operators at high frequency
Creators: name: Galkowski, Jeffrey
name: Han, Xiaolong
name: Tacy, Melissa
Publisher: name: arXiv
Year: 2014
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: In this paper, we investigate single and double layer potentials mapping boundary data to interior functions of a domain at high frequency $λ^2\to\infty$. For single layer potentials, we find that the $L^{2}(\partialΩ)\to{}L^{2}(Ω)$ norms decay in $λ$. The rate of decay depends on the curvature of $\partialΩ$: The norm is $λ^{-3/4}$ in general domains and $λ^{-5/6}$ if the boundary $\partialΩ$ is curved. The double layer potential, however, displays uniform $L^{2}(\partialΩ)\to{}L^{2}(Ω)$ bounds independent of curvature. By various examples, we show that all our estimates on layer potentials are sharp. The appendix by Galkowski gives bounds $L^{2}(\partialΩ)\to{}L^{2}(\partialΩ)$ for the single and double layer operators at high frequency that are sharp modulo $\log λ$. In this case, both the single and double layer operator bounds depend upon the curvature of the boundary.
description: The paper authored by Xiaolong Han and Melissa Tacy now includes an appendix by Jeffrey Galkowski on double layer operators
ContrastNER: Contrastive-based Prompt Tuning for Few-shot NER
Creators: name: Layegh, Amirhossein
name: Payberah, Amir H.
name: Soylu, Ahmet
name: Roman, Dumitru
name: Matskin, Mihhail
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computation and Language (cs.CL)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Prompt-based language models have produced encouraging results in numerous applications, including Named Entity Recognition (NER) tasks. NER aims to identify entities in a sentence and provide their types. However, the strong performance of most available NER approaches is heavily dependent on the design of discrete prompts and a verbalizer to map the model-predicted outputs to entity categories, which are complicated undertakings. To address these challenges, we present ContrastNER, a prompt-based NER framework that employs both discrete and continuous tokens in prompts and uses a contrastive learning approach to learn the continuous prompts and forecast entity types. The experimental results demonstrate that ContrastNER obtains competitive performance to the state-of-the-art NER methods in high-resource settings and outperforms the state-of-the-art models in low-resource circumstances without requiring extensive manual prompt engineering and verbalizer design.
description: 9 pages, 5 figures, COMPSAC2023
title: Pitch decoding and encoding in individuals with and without Autism Spectrum Disorder
Creators: name: Wang, Li
Publisher: name: University of Reading
Year: 2023

description: How pitch is processed has been investigated across different auditory domains (speech vs. music), processing levels (low-level vs. high-level), and modalities (perception vs. production) in individuals with autism spectrum disorder (ASD). However, mixed results have been reported with no substantial evidence to inform the ongoing theoretical debates in ASD, such as (a) whether speech and music processing share underlying mechanisms; (b) whether perception correlates with production; and (c) whether high-level information processing is intact in individuals with ASD. The present thesis reports three studies that examine pitch processing in individuals with and without ASD to inform the three aforementioned theoretical debates and to reconcile inconsistencies across studies. In relation to pitch processing in speech versus music, the results show that pitch perception in both domains is intact in individuals with ASD. However, when imitating speech and song, individuals with ASD demonstrate impaired absolute but not relative pitch production. These findings from perception and production suggest that speech and music pitch processing, whether intact or impaired, likely share underlying mechanisms. With respect to the relationship between perception and production, the findings indicate an association between these two modalities, since the ability to identify statement-question intonation is associated with the ability to imitate the intonation in both groups. Concerning low- and high-level processing, the findings reveal that high-level processing is not impaired in ASD, and that sensitivity to low-level pitch predicts performance on higher-level processing in both groups. Furthermore, perception ability increases with age in individuals with and without ASD whereas imitation ability does not. The findings from this thesis heighten our understanding of how pitch is decoded and encoded in ASD, and provide theoretical implications for pitch processing in this population and in typical development.
title: The Marketing Process - Background Note
Creators: name: Tavassoli, Nader
Publisher: name: London Business School
Year: 2020
Subjects: subject: FOS: Economics and business
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: The Chartered Institute of Marketing in the UK defines marketing as: 'The management process responsible for identifying, anticipating and satisfying customer requirements profitably'.  This note describes the marketing process
description: LBS Case Code: BCN-001-20
Horizons of semiclassical black holes are cold
Creators: name: Brustein, Ram
name: Medved, A. J. M.
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We calculate, using our recently proposed semiclassical framework, the quantum state of the Hawking pairs that are produced during the evaporation of a black hole (BH). Our framework adheres to the standard rules of quantum mechanics and incorporates the quantum fluctuations of the collapsing shell spacetime in Hawking's original calculation, while accounting for back-reaction effects. We argue that the negative-energy Hawking modes need to be regularly integrated out; and so these are effectively subsumed by the BH and, as a result, the number of coherent negative-energy modes $N_{coh}$ at any given time is parametrically smaller than the total number of the Hawking particles $N_{total}$ emitted during the lifetime of the BH. We find that $N_{coh}$ is determined by the width of the BH wavefunction and scales as the square root of the BH entropy. We also find that the coherent negative-energy modes are strongly entangled with their positive-energy partners. Previously, we have found that $N_{coh}$ is also the number of coherent outgoing particles and that information can be continually transferred to the outgoing radiation at a rate set by $N_{coh}$. Our current results show that, while the BH is semiclassical, information can be released without jeopardizing the nearly maximal inside-out entanglement and imply that the state of matter near the horizon is approximately the vacuum. The BH firewall proposal, on the other hand, is that the state of matter near the horizon deviates substantially from the vacuum, starting at the Page time. We find that, under the usual assumptions for justifying the formation of a firewall, one does indeed form at the Page time. However, the possible loophole lies in the implicit assumption that the number of strongly entangled pairs can be of the same order of $N_{total}$.
description: Replaced to agree with the published version. Added clarifications and explanations, error corrected in the calculation of the reduced density matrix in Sect. 6, conclusions unchanged. 48 pages, 1 figure
Extracellular calcium exerts a dual effect on renin secretion from isolated mouse juxtaglomerular cells
Creators: name: Schricker, Karin
name: Della Bruna, R.
name: Kurtz, Armin
Publisher: name: Universität Regensburg
Year: 1993
Subjects: subject: 570 Biowissenschaften, Biologie
subject: 610 Medizin
subject: Animals
subject: Calcium/pharmacology
subject: Cells, Cultured
subject: Cobalt/pharmacology
subject: Cyclic GMP/pharmacology
subject: Egtazic Acid/pharmacology
subject: Forskolin/pharmacology
subject: Juxtaglomerular Apparatus/secretion
subject: Male
subject: Mice
subject: Mice, Inbred C57BL
subject: Renin/secretion
subject: Sucrose/pharmacology
subject: Thionucleotides/pharmacology

description: Utilizing primary cultures of mouse renal juxtaglomerular cells we found that renin secretion during 20 h of incubation was stimulated by 100% when extracellular calcium was lowered from a basal level of 0.5 mM to below 1 microM, and was enhanced in a concentration-dependent fashion by 600% when extracellular calcium was increased up to 10 mM. The stimulatory effect of low calcium on renin secretion was apparent after the first hour of incubation, whereas the stimulatory effect of increased calcium occurred with a delay of at least 1 h. During the first hour of incubation increased extracellular calcium blunted the stimulation of renin secretion induced by forskolin (10 microM). The stimulatory effect of increased calcium was attenuated in the presence of 8-pCPT-cGMP, a membrane-permeable cGMP analogue, and in the presence of 100 mM sucrose. The stimulatory effect of increased calcium was blunted in the presence of 0.5 mM cobalt, which itself stimulated renin secretion at normal (0.5 mM) calcium concentrations. Renin synthesis by the cultured cells at low calcium was markedly attenuated in proportion with total protein synthesis, whereas renin synthesis was not altered at increased calcium concentrations. Our findings suggest that a rise of intracellular calcium, induced by an increase of extracellular calcium, is associated with a transient inhibition followed by a marked and regulatable stimulation of renin secretion. Neither calcium depletion nor calcium elevation appears to exert specific effects on renin synthesis in juxtaglomerular cells.
Hagerman's three-word sentences
Creators: name: Hermansson, Emma
name: Malmberg, Milijana
name: Hagerman, Björn
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Hagerman's sentences
subject: Speech audiometry
subject: Matrix test
subject: Children
subject: Hagermans meningar

description: Sound recordings and other supplementary materials for Hagerman's three word-sentences (shortened versions of the standard five-word sentences)
Team microBIOME Fall 2020 - DIY microbiome analysis
Creators: name: Smyth, Davida
name: Tarun, Alice
name: Girtain, Christine
name: Lenahan, Melanie
name: Goytia, Maira
name: Sompanya, Khuanchivin
name: Muth, Theodore
Publisher: name: QUBES Educational Resources
Year: 2020

description: This is our final team report for this year's BIOME Institute 2020. Learn about what we got up to and what we're planning for Spring 2021. If you want more information on REMNet go here https://qubeshub.org/community/groups/remnet
Oxygen-dependent expression of the erythropoietin gene in rat hepatocytes in vitro
Creators: name: Eckardt, Kai-Uwe
name: Pugh, C. W.
name: Ratcliffe, P. J.
name: Kurtz, Armin
Publisher: name: Universität Regensburg
Year: 1993
Subjects: subject: 570 Biowissenschaften, Biologie
subject: 610 Medizin
subject: Animals
subject: Anoxia/metabolism
subject: Cell Survival/drug effects
subject: Cells, Cultured
subject: Centrifugation
subject: Erythropoietin/genetics
subject: Gene Expression Regulation/physiology
subject: Liver/metabolism
subject: Male
subject: Oxygen/physiology
subject: Protein Biosynthesis
subject: Protein Synthesis Inhibitors/pharmacology
subject: RNA, Messenger/metabolism
subject: Rats
subject: Rats, Sprague-Dawley
subject: Second Messenger Systems/drug effects

description: Since in juvenile rats the liver is the predominant site of erythropoietin (EPO) gene expression, we have used primary cultures of juvenile rat hepatocytes to establish and in vitro system for investigation of oxygen-dependent EPO formation. When isolated hepatocytes were incubated at reduced oxygen tensions for 18-48 h, we found increased secretion of EPO protein and elevated levels of EPO mRNA, as determined by RNas protection. This increase was maximal at 3% O2, where EPO mRNA levels after 18 h were approximately 15-fold higher than at 20% O2. The increase in EPO mRNA at low oxygen tensions was specific insofar as [3H]uridine incorporation, as a measure of total RNA synthesis, was reduced by approximately 50% at 3% O2, and it appeared to involve gene transcription since it was abolished in the presence of actinomycin D (35 microM). Significant increases in EPO mRNA were also observed in cells kept at 20% oxygen in the presence of cobalt chloride (50 microM) and nickel chloride (400 microM), but EPO mRNA levels achieved under these conditions were less than 7% of those in cells incubated at 3% oxygen. No increase in EPO mRNA levels was observed in cultures incubated at 20% O2 in the presence of cyclic dibutyryl-AMP (10 microM-3 mM), cyclic 8-bromoGMP (10 microM-1 mM), cyclohexyladenosine (1 microM), 5'-N-ethylcarboxamidoadenosine (1 microM) and phorbol 12-myristate 13-acetate (3 nM). In the presence of 10% carbon monoxide, used to block haem proteins in their oxy conformation, EPO mRNA levels in hepatocytes incubated at low oxygen tensions were reduced to 63%.(ABSTRACT TRUNCATED AT 250 WORDS)
New chemical resins for SLA-based 3D printers
Creators: name: Shahzadi, L
Publisher: name: University of Tasmania
Year: 2023

description: Advances in additive manufacturing (often referred to as ‚ÄövÑv¿3D printing‚ÄövÑvp) technologies have greatly simplified prototype manufacturing and complex design over the past decade. One particular class of 3D printing, namely stereolithography (SLA) and its variants, has particular appeal due to the ability to create objects with small feature sizes and high resolution. However, most commercially available SLA material components are based on (meth)acrylate-based resin systems that have several disadvantages associated with their use, such as inhibition of polymerisation by oxygen, solvent resistance, and the inability to modify surfaces post-printing. The aims of this work were to prepare new chemical resins for SLA-based 3D printers to reduce the disadvantages associated with (meth)acrylate-based commercial resins. Polymerisation via a thiol-acrylate/alkene/alkyne mechanism can help overcome many of these drawbacks, however, these systems are less studied in the context of SLA 3D printing. In this work, firstly, we report the design and optimisation of thiol-acrylate resin formulations with a view towards effectively controlling the polymerisation depth of the cured polymer layer. Four different photo-blockers were studied and the use of 1,3-bis(4-methoxyphenyl)propane-1,3-dione enabled optically transparent and colourless printed objects with good resolution to be realised. Taking advantage of ready post-printing surface modification of thiol-acrylate polymers, various hydrophilic, hydrophobic, and fluorescent polymer chains were successfully grafted to the object surface via RAFT polymerisation. Free thiol groups at the surface of offstoichiometric resin formulations were also used to immobilize gold nanoparticles for the catalytic conversion of 4-nitrophenol to 4-aminophenol. Secondly, A new 3D printable resin formulation was developed and optimised from commercially available thiol-alkyne monomers. A 3D device was designed from the resin formulation to remove malachite green (MG) from real water samples collected from tap and river, respectively. The results displayed excellent dye removal efficiency, and >95% dye was removed within 5 min. The 3D printed devices were found to be recyclable and removed 100% dye over 6 times after simple washing with de-ionized water and methanol. Thirdly, new alkyne-based monomers were synthesised in house and optimised to prepare formulations for SLA printing. The prepared materials exhibited better solvent resistance and mechanical properties compared to the acrylate-based formulations. The free alkyne surface groups were utilised for post-print alkyne-azide click polymerisation. The successful development of these resins has resulted in novel systems for stereolithography (SLA) 3D printing. The easily tuneable resin composition and post-print surface modifications make them an attractive candidate for SLA printers as well as hold immense potential for broad commercial applications.
Concept of effective states of atoms in compounds to describe properties determined by the densities of valence electrons in atomic cores
Creators: name: Titov, Anatoly V.
name: Lomachuk, Yuriy V.
name: Skripnikov, Leonid V.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: A new approach for describing the effective electronic states of "atoms in compounds" to study the properties of molecules and condensed matter which are circumscribed by the operators heavily concentrated in atomic cores is proposed. Among the properties are hyperfine structure, space parity (P) and time reversal invariance (T) nonconservation effects, chemical shifts of x-ray emission lines (XES), Mössbauer effect, etc. Advantage of the approach is that a good quantitative agreement of predicted and experimental data can be attained even for such difficult cases as XES chemical shifts providing correct quantum-mechanical interpretation of the experimental data. From computational point of view the method can be quite efficient being implemented in the framework of the relativistic pseudopotential theory [Int.J. Quantum Chem. 71, 359 (1999)] and procedures of recovering the wave functions in heavy-atom cores [Int.J. Quantum Chem. 104, 223 (2005)] after a molecular, cluster or periodic structure calculation performed on the basis of pseudoorbitals smoothed near the nuclei within the pseudopotential approximation. We report results of our studies of a number of atomic and molecular systems to demonstrate the capabilities of the approach.
description: 10 pages, 2 figures
title: Satya Nadella at Microsoft: Instilling a Growth Mindset (Spanish)
Creators: name: Ibarra, Herminia
name: Rattan, Aneeta
Publisher: name: London Business School
Year: 2016
Subjects: subject: FOS: Economics and business
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: When Satya Nadella took over as CEO of Microsoft in 2014, he inherited a firm fading toward irrelevance, plagued by internal fights and inertia. Earlier that year his wife, Anu, had given him a best-selling book by Stanford psychologist Carol Dweck entitled Mindset: The New Psychology of Success, suspecting it might give Nadella some ideas for Microsoft. He adapted the idea to encourage employees to shift from Microsoft's historical 'know-it-alls' culture to embrace a 'learn-it-alls' curiosity. The case study provides background on Nadella's challenges and context, as well as how he and his leadership team executed their culture change effort.
description: LBS Case Code: CS-18-008_ES
title: ICDP Project DOVE (Drilling Overdeepened Alpine Valleys): First results from the Basadingen Borehole
Creators: name:   Schaller ,  Sebastian
name:   Anselmetti ,  Flavio
name:   Büchi ,  Marius
name:   Fiebig ,  Markus
name:   Gabriel ,  Gerald
name:   Kroemer ,  Ernst
name:   Preusser ,  Frank
name:   Reitner ,  Jürgen
name:   Schuster ,  Bennet
name:   Tanner ,  David
name:   Wielandt-Schuster ,  Ulrike
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: The panalpine project "DOVE" (Drilling Overdeepened Alpine Valleys), co-funded by the International Continental Scientific Drilling Program (ICDP), is drilling a series of overdeepened glacial troughs around the Alps that were formed by subglacial erosion during past glaciations. The sedimentary fill of these troughs, consisting of multiple stacked and nested glacial sequences, provides the best archives of when and where glaciers reached the Alpine forelands. The combined data from all DOVE sites comprising synchronous or asynchronous ice advances and ice extents in the different regions, will eventually provide a critical database to evaluate the various patterns in glacial-interglacial paleoclimates and landscape evolution back to the Mid-Pleistocene. One of the DOVE sites drilled the overdeepened Basadingen Trough, located in Northern Switzerland, within the extents of several Middle-Late Pleistocene foreland glaciations of a lobe of the Rheine Glacier. The trough is a narrow, ca. 250-300 m deep structure that runs SSE-NNW, forming a so-far poorly understood, old overdeepened valley system that connected the present-day Thur Valley with the Rhine Valley – a connection that does not exist in the present surface morphology and that was probably only active during the Middle Pleistocene. New high-resolution 2-D seismic displays a detailed seismic stratigraphy with several depositional sequences, indicating that the valley fill consists of deposits from multiple glaciations, making the Basadingen Trough an ideal target for DOVE. We aim to establish a chronostratigraphic and sedimentological model to identify and understand the older glaciations that affected the Basadingen Trough and the Northern Alpine foreland in general.
Proper holomorphic mappings of balanced domains in $\mathbb{C}^n$
Creators: name: Janardhanan, Jaikrishnan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Complex Variables (math.CV)
subject: FOS: Mathematics
subject: 32H35

description: We extend a well-known result, about the unit ball, by H. Alexander to a class of balanced domains in $\mathbb{C}^n, \ n > 1$. Specifically: we prove that any proper holomorphic self-map of a certain type of balanced, finite-type domain in $\mathbb{C}^n, \ n > 1$, is an automorphism. The main novelty of our proof is the use of a recent result of Opshtein on the behaviour of the iterates of holomorphic self-maps of a certain class of domains. We use Opshtein's theorem, together with the tools made available by finiteness of type, to deduce that the aforementioned map is unbranched. The monodromy theorem then delivers the result.
description: 12 pages; article extensively rewritten; additional hypothesis added to the main result; to appear in Math. Zeitschrift
title: Takeda: The governance of strategic transformation (A)
Creators: name: Korine, Harry
name: Asakawa, Kazuhiro
Publisher: name: London Business School
Year: 2018
Subjects: subject: FOS: Economics and business
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: The case series describes strategic transformation at Takeda, the largest Japanese pharmaceutical company, with a special focus on the R&D function. Since 2015, the 237-year-old industry doyen has narrowed its strategic focus from six to three therapeutic areas, reorganised its global R&D footprint around one Japanese and two US sites, and engaged in over 180 new partnerships across multiple modalities of drug discovery around the world. The pipeline of new drugs, a key gauge of future growth, has shifted from 7% partner-based pre-transformation to approximately 45% partner-based today, and an entrepreneurial, geocentric way of working has taken hold. At Takeda, a generation's worth of strategic transformation has been compressed into three years.From the outset of the transformation process, outgoing Chairman Yasu Hasegawa and incoming CEO Christophe Weber made it a point to sound out major shareholders and engage candidly with the union, working with different stakeholders to find novel organisational solutions. Once plans crystallised in 2016, Hasegawa and Weber moved to reconstitute the board of directors, changing its composition and renegotiating its modus operandi to further strategic dialogue. During the course of the same year, the executive team was recast around people s'“ internal and external s'“ who had the skills and the mindset to take the company forward on its new path. Early in 2017, executives finally initiated a review and adjustment of existing structures in R&D, particularly as they pertained to the burgeoning partnership portfolio. In other words, Takeda stands out not only as a rare example of a large company reinventing itself, but also as a case that illustrates the importance of proactively addressing the governance of transformation.
description: LBS Case Code: CS-18-24
Second Quantized Scalar QED in Homogeneous Time-Dependent Electromagnetic Fields
Creators: name: Kim, Sang Pyo
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We formulate the second quantization of a charged scalar field in homogeneous, time-dependent electromagnetic fields, in which the Hamiltonian is an infinite system of decoupled, time-dependent oscillators for electric fields, but it is another infinite system of coupled, time-dependent oscillators for magnetic fields. We then employ the quantum invariant method to find various quantum states for the charged field. For time-dependent electric fields, a pair of quantum invariant operators for each oscillator with the given momentum plays the role of the time-dependent annihilation and the creation operators, constructs the exact quantum states, and gives the vacuum persistence amplitude as well as the pair-production rate. We also find the quantum invariants for the coupled oscillators for the charged field in time-dependent magnetic fields and advance a perturbation method when the magnetic fields change adiabatically. Finally, the quantum state and the pair production are discussed when a time-dependent electric field is present in parallel to the magnetic field.
description: RevTex 12 pages, no figure; replaced by the version to be published in Ann. Phys
Pharmacokinetics of recombinant human erythropoietin applied subcutaneously to children with chronic renal failure
Creators: name: Braun, A.
name: Ding, R.
name: Seidel, C.
name: Fies, T.
name: Kurtz, Armin
name: Schärer, K.
Publisher: name: Universität Regensburg
Year: 1993
Subjects: subject: 570 Biowissenschaften, Biologie
subject: 610 Medizin
subject: Adolescent
subject: Adult
subject: Child
subject: Erythropoietin/therapeutic use
subject: Female
subject: Humans
subject: Injections, Intravenous
subject: Injections, Subcutaneous
subject: Kidney Failure, Chronic/metabolism
subject: Male
subject: Recombinant Proteins/therapeutic use

description: The single-dose pharmacokinetics of recombinant human erythropoietin (rHuEPO) given SC was investigated in 20 patients aged 7-20 years at different stages of chronic renal failure. In a pilot study we confirmed the lower bioavailability of the drug in 2 children when given SC compared with the IV route (24% and 43%, respectively). Following administration of 4,000 units/m2, rHuEPO SC effective serum erythropoietin concentrations increased from a mean baseline level (+/- SD) of 23 +/- 13 units/l to a mean peak concentration of 265 +/- 123 units/l, which was reached after 14.3 +/- 9.4 h, followed by a slow decline until baseline values were attained at 72 h. Mean residence time was 30 +/- 9 h and mean elimination half-time 14.3 +/- 7 h. The single-dose kinetics of SC rHuEPO in children with different degrees of renal failure are comparable to those in adult patients. Possibly, the higher efficacy of SC rHuEPO in patients with renal anaemia compared with IV rHuEPO is related to its prolonged action.