cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Genomic dissection of arrhythmia and cardiac electromechanics
Creators: name: Ware, James
Publisher: name: Imperial College London
Year: 2012

description: Cardiac arrhythmia is a leading cause of death in the developed world and a final common pathway for many forms of cardiac disease. Rare inherited arrhythmia syndromes contribute to this disease burden, particularly through sudden death in the young. The study of rare syndromes, such as inherited arrhythmia, can also identify genes and pathways important in common diseases. Here, genomic approaches were applied to dissect genetic determinants of cardiac arrhythmia, through gene discovery, variant discovery, and variant annotation. First, whole-exome sequencing was used to identify the genetic basis of an unexplained inherited arrhythmia syndrome. Linkage analysis and conventional sequencing excluded known causative genes in a family with Brugada Syndrome, and whole exome sequencing identifie d a shortlist of five new candidate genes that may lead to a genetic diagnosis in this family and new insights into the pathogenesis of the condition. Following the identification of genes responsible for inherited arrhythmia syndromes, the recognition of specific disease-causing variants in those genes allows for clinical application, including molecular diagnosis, cascade screening and stratified therapy. Here, two high-throughput next-generation sequencing approaches for the detection of variants in these genes were compared, technically evaluated, and optimis ed. This represents the de novo establishment of next-generation sequencing technologies and analysis pathways in our laboratory, and provides a platform for molecular diagnosis and future genotype-phenotype correlation studies. Finally, a novel approach for the functional annotation of non-synonymous variants was developed. This approach, termed “Paralogous Annotation”, identifies functionally important, disease-associated residues across protein families using multiple sequence alignment. Paralogous Annotation was validated here by demonstrating the accurate identification of disease-causing variation in genes that cause long QT syndrome – an important cause of sudden death. This methodology is widely applicable to annotate Mendelian human disease genes.
Hyperparameter Optimization for Randomized Algorithms: A Case Study on Random Features
Creators: name: Dunbar, Oliver R. A.
name: Nelsen, Nicholas H.
name: Mutic, Maya
Publisher: name: arXiv
Year: 2024
Subjects: subject: Machine Learning (cs.LG)
subject: Computation (stat.CO)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: Randomized algorithms exploit stochasticity to reduce computational complexity. One important example is random feature regression (RFR) that accelerates Gaussian process regression (GPR). RFR approximates an unknown function with a random neural network whose hidden weights and biases are sampled from a probability distribution. Only the final output layer is fit to data. In randomized algorithms like RFR, the hyperparameters that characterize the sampling distribution greatly impact performance, yet are not directly accessible from samples. This makes optimization of hyperparameters via standard (gradient-based) optimization tools inapplicable. Inspired by Bayesian ideas from GPR, this paper introduces a random objective function that is tailored for hyperparameter tuning of vector-valued random features. The objective is minimized with ensemble Kalman inversion (EKI). EKI is a gradient-free particle-based optimizer that is scalable to high-dimensions and robust to randomness in objective functions. A numerical study showcases the new black-box methodology to learn hyperparameter distributions in several problems that are sensitive to the hyperparameter selection: two global sensitivity analyses, integrating a chaotic dynamical system, and solving a Bayesian inverse problem from atmospheric dynamics. The success of the proposed EKI-based algorithm for RFR suggests its potential for automated optimization of hyperparameters arising in other randomized algorithms.
Interaction and localisation studies of the lipoteichoic acid synthesis proteins in staphylococcus aureus
Creators: name: Reichmann, Nathalie
Publisher: name: Imperial College London
Year: 2012

description: Lipoteichoic acid (LTA) is an important component of the cell envelope of various Gram-positive bacteria. In Staphylococcus aureus it consists of a polyglycerolphosphate chain that is decorated with D-alanine esters and anchored to the cell membrane via a glycolipid. The lack of D-alanine modifications leads to increased susceptibility to cationic antimicrobial peptides and the complete absence of LTA results in aberrant positioning of septa, enlargement of cells and eventual cell lysis, indicating a link between LTA synthesis and cell division. Although key enzymes required for LTA synthesis and D-alanylation have been identified, the full process has not been elucidated and is investigated in this study. Using a bacterial two-hybrid approach it was shown that the three key LTA synthesis enzymes, YpfP, LtaA and LtaS, interact with one another, indicating the formation of a multi-enzyme complex. In addition, these three proteins interacted with numerous cell division and peptidoglycan synthesis proteins. Fluorescence microscopy studies indicated that YpfP and LtaA localise to the membrane, while LtaS appeared to accumulate at the site of cell division in cells with fully formed septa. Together, these data provide further experimental evidence for the coordination between the processes of cell division and LTA synthesis. Four proteins, DltA-D, are essential for the D-alanylation of LTA. The mechanism begins with DltA transferring D-alanines onto the carrier protein DltC. However, Fischer and colleagues, and Neuhaus and Baddiley have proposed two conflicting models for the remainder of the mechanism for D-alanylation. Here, using a cellular protein localisation analysis it was shown that DltC does not traverse the membrane and membrane topology studies indicated that DltD is anchored to the outside of the cell, contrary to the Neuhaus and Baddiley model. In summary, the data presented in this study are in support of the D-alanine substitution model proposed by Werner Fischer.
title:  Testing Social Disorganization as It Pertains to Prostitution
Creators: name: Edwards, Wynter Leighanne
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 2006

description: The impact of crime on the community has gained notoriety within the sociological field over the last twenty years. With growing citizen concern it is important to understand the impact of crimes rates on communities. Social disorganization theory focuses on the relationship between crime and the community, however, little research has been done on social disorganization theory as it relates to victimless crimes such as prostitution. It is important to understand how variables derived from social disorganization theory explain levels of prostitution across neighborhoods. This is important because victimless crimes such as prostitution often act as precursors to greater crime problems within the community. Results of this research support the substance of social disorganization and shows that the theory applies to victimless crimes such as prostitution.
Additional file 1: of Heterogeneous combinatorial expression of Hoxd genes in single cells during limb development
Creators: name: P. Fabre
name: M. Leleu
name: B. Mascrez
name: Q. Lo Giudice
name: J. Cobb
name: D. Duboule
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Figure S1. Schematic of Tau::GFP targeting into the Hoxd11 gene. The TAU::GFP sequences were introduced into the posterior part of the HoxD complex (A). A bi-cistronic cassette along with an IRES sequence was inserted in frame with the coding sequence of the Hoxd11 gene (B) and a TauGFP (C). The BamH1 site (A) was used for the insertion of the IRES cassette. D. Schematic showing how the cassette was introduced as a single-copy knock-in. (PDF 134 kb)
Autofib Redshift Survey - I. Evolution of the Galaxy Luminosity Function
Creators: name: Ellis, Richard S.
name: Colless, Matthew
name: Broadhurst, Tom
name: Heyl, Jeremy
name: Glazebrook, Karl
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present a detailed determination of the restframe B-band galaxy luminosity function (LF) as a function of redshift and star formation activity from z=0 to z=0.75. The dataset used for this purpose is a combined sample of over 1700 redshifts spanning a wide range in apparent magnitude, 11.5
description: To appear in MNRAS, 16 pages, Postscript only
Hadronic Top Quark Polarimetry with ParticleNet
Creators: name: Dong, Zhongtian
name: Gonçalves, Dorival
name: Kong, Kyoungchul
name: Larkoski, Andrew J.
name: Navarro, Alberto
Publisher: name: arXiv
Year: 2024
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Precision studies for top quark physics are a cornerstone of the Large Hadron Collider program. Polarization, probed through decay kinematics, provides a unique tool to scrutinize the top quark across its various production modes and to explore potential new physics effects. However, the top quark most often decays hadronically, for which unambiguous identification of its decay products sensitive to top quark polarization is not possible. In this Letter, we introduce a jet flavor tagging method to significantly improve spin analyzing power in hadronic decays, going beyond exclusive kinematic information employed in previous studies. We provide parametric estimates of the improvement from flavor tagging with any set of measured observables and demonstrate this in practice on simulated data using a Graph Neural Network (GNN). We find that the spin analyzing power in hadronic decays can improve by approximately 20% (40%) compared to the kinematic approach, assuming an efficiency of 0.5 (0.2) for the network.
description: 7 pages and 3 figures
Anas adunca Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Anseriformes
Anatidae
Anas
Anas adunca

description: Anas adunca [spec. nov.]
A. rectricibus intermediis (maris) recurvatis, rostro incurvato.
Anas domestica, rostro adunco. Will. orn. 280. Raj. av. 150. Alb. av. 2. p. 86. t. 97. 96.
Habitat in.; hodie uti praecedens domestica.
Quomodo haec a priori exorta sit me fugit.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 128, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Additional file 2: of Longitudinal monitoring of Culicoides in Belgium between 2007 and 2011: local variation in population dynamics parameters warrant cautious use of monitoring data
Creators: name: Sohier, Charlotte
name: Isra Deblauwe
name: Deken, Reginald De
name: Madder, Maxime
name: Fassotte, Christiane
name: Losson, Bertrand
name: Regge, Nick De
Publisher: name: figshare
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: Developmental Biology
subject: Marine Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Table S2. Species diversity and relative abundance (%) of Culicoides collected with OVI traps from 2007 to 2011 at 7 sites in Belgium). (DOCX 28 kb)
The Environment of ``E+A'' Galaxies
Creators: name: Zabludoff, A. I.
name: Zaritsky, D.
name: Lin, H.
name: Tucker, D.
name: Hashimoto, Y.
name: Shectman, S. A.
name: Oemler, A.
name: Kirshner, R. P.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The violent star formation history of ``E+A'' galaxies and their detection almost exclusively in distant clusters is frequently used to link them to the ``Butcher-Oemler effect'' and to argue that cluster environment influences galaxy evolution. From 11113 spectra in the Las Campanas Redshift Survey, we have obtained a unique sample of 21 nearby ``E+A" galaxies. Surprisingly, a large fraction (about 75%) of these ``E+A''s lie in the field. Therefore, interactions with the cluster environment, in the form of the ICM or cluster potential, are not essential for ``E+A'' formation. If one mechanism is responsible for ``E+A''s, their existence in the field and the tidal features in at least 5 of the 21 argue that galaxy-galaxy interactions and mergers are that mechanism. The most likely environments for such interactions are poor groups, which have lower velocity dispersions than clusters and higher galaxy densities than the field. In hierarchical models, groups fall into clusters in greater numbers at intermediate redshifts than they do today. Thus, the Butcher-Oemler effect may reflect the typical evolution of galaxies in groups and in the field rather than the influence of clusters on star formation in galaxies. This abstract is abridged.
description: 39 uuencoded, compressed pages (except Fig 1), complete preprint at ftp://ociw.edu/pub/aiz/eplusa.ps, ApJ, submitted
Facies architecture of the fluvial to tidal transition of mixed-influence deltas
Creators: name: Van Cappelle, Marijn
Publisher: name: Imperial College London
Year: 2016

description: Coastal deposits are often classified based on the depositional processes (wave, tide, fluvial) which operate in the depositional environment. The mix of processes operating during deposition have an effect on the size, shape, orientation and internal heterogeneities of sand- and sandstone bodies. It is important to know these properties for predicting and modelling fluid flow through aquifers. Facies models for fluvial-dominated deltas and wave-dominated shorefaces are well established and widely used. However, although there are many modern tide-influenced deltas, research in facies models for tide-influenced deltas lags behind to their better studies fluvial- and wave-dominated counterparts. This is partially because tide-dominated deposits are often interpreted in a sequence stratigraphic framework as transgressive tide-dominated estuaries. The aim of this study is to present a facies model for mixed-influence deltas, with emphasis on the preservation of channelised fluvial- and tidal channels in a progradational setting. Two case studies are part of this thesis. Firstly, outcrops of the Upper Cretaceous Sego Sandstone (Utah, USA) have been studied in order to investigate the facies architecture of a mixed tide- and wave influenced deltaic deposit. Secondly, cores of the mixed influence Lower to Middle Jurassic Ror, Tofte and Ile formation from the subsurface of the Halten Terrace (offshore mid-Norway) have been examined. Both case studies were deposited in structurally controlled embayments which favoured amplification of tides. Both case studies show an initial progradational phase with little evidence for tidal processes. In contrast, deposits on the delta plain show abundant evidence for tidal currents. In this study, it has been interpreted that these channelised tidal channels are part of continuous progradation of a tide-influenced delta. This is in contrast to sequence stratigraphic models in which tide-dominated deposits are interpreted as part of a transgressive phase. During progradation, these tidal and fluvial channels erode down in underlying deposits and they are deposited in progressively more basin-ward positions. More tide-dominated channels deposited in relatively distal or off-axis locations have a more planar geometry. More fluvial-dominated channels deposited in relatively proximal or on-axis location are more lenticular.
The Square Kilometer Array Interferometer
Creators: name: Braun, Robert
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The scientific motivation is reviewed for a next generation radio observatory operating at frequencies between about 200 MHz and 2 GHz with about 2 orders of magnitude greater sensitivity than that which is currently available, together with sub-arcsecond angular resolution. Instrumental concepts for the telescope are discussed, highlighting the role of mass produced receiver elements and digital electronics in increasing cost-effectiveness while actively reducing the instrument's sensitivity to radio frequency interference.
description: 13 page LaTeX requires crckapb.sty and psfig.sty, 7 compressed and tarred postscript figures (560kB) available at ftp://ftp.nfra.nl/pub/outgoing/rbraun/skai/figs.tar.Z Complete compressed postscript paper (615kB) available at ftp://ftp.nfra.nl/pub/outgoing/rbraun/skai/paper.ps.Z To appear in "The Westerbork Synthesis Telescope, It's 25th Anniversary and Beyond" Eds. E.Raimond and R.Genee (Kluwer, Dordrecht)
Constraining the high-redshift quasar luminosity function
Creators: name: Finer, Jasmine Liliane Barnard
Publisher: name: Imperial College London
Year: 2016

description: Accretion onto supermassive black holes powers quasars so luminous that they can be observed at high redshifts. However, mass estimates of these quasars are in conflict with current theories of black hole growth during these early epochs. The root of this inconsistency lies within our theoretical understanding of black hole formation and evolution at high redshift, methods of estimating high redshift black hole masses, and the statistical approach to constraining the high redshift black hole population. This thesis focuses on the latter. We propose a correction to the completeness of the z~6 Stripe 82 survey (Jiang 2009) in the form of a shift in magnitude limit of ∆M_1450 = - 0.47. We present an updated formalism of parameter inference for the quasar luminosity function, using a 6 parameter double power law model [Equation goes here please see PDF version] and find maximum a posteriori estimates beta = -3.76, M*_1450=-26.5, j = 0.0849, Phi*= 3.25 x 10^-9 Mpc^-3, alpha = -1.73, k = -0.165. In comparison to previous work on the redshift $6$ quasar luminosity function (Willott 2010a), our modelling prefers a steeper fall off at the QLF's bright end, a brighter break magnitude which evolves slowly with redshift and a more gradual decrease in number density with redshift.
Mixing by squirmers in stratified fluids
Creators: name: Shaik, Vaseem A.
name: Elfring, Gwynn J.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We find the mixing induced by a small swimming organism in a density stratified fluid. We model the swimmer as a spherical squirmer and quantify mixing through a mixing efficiency that is the ratio of rate of change of potential energy of fluid to the total work done by the swimmer. Assessing mixing in the near field and far field of the swimmer separately, we find that the near-field mixing aligns with past work, but the overall mixing is much larger than that caused by a point-sized swimmer (like force-dipole), although still small in weak stratification. Equivalent results are also obtained for a homogeneous dilute suspension of non-interacting swimmers. Our study highlights the impact of swimmer size on mixing, revealing that small-sized swimmers cannot induce substantial mixing. However, we propose few (unexplored) pathways through which small swimmers could induce significant mixing, ultimately contributing towards oceanic mixing.
description: 13 pages
Improved outcome prediction in tetralogy of Fallot
Creators: name: Heng, Ee Ling
Publisher: name: Imperial College London
Year: 2016

description: Successful advances in cardiac surgery have led to a paradigm shift in the management of an expanding population of repaired tetralogy of Fallot (rTOF) patients. However, late morbidity and mortality have not been abolished, with patients vulnerable to arrhythmia and sudden death. Outcome prediction remains challenging, mandating the identification of novel sensitive and specific non-invasive biomarkers. Cardiac fibrosis in rTOF has been shown to correlate to adverse clinical features, and therefore merits further study, particularly with regards to interstitial fibrosis. Cardiac remodelling following surgical pulmonary valve replacement in patients with rTOF was investigated. Structural reverse remodelling was observed to occur immediately after surgery, followed by gradual biological remodelling. A proactive surgical approach before right ventricular (RV) end-systolic indexed volumes exceed 82ml/m2 confers optimal postoperative RV normalisation. Novel cardiovascular magnetic resonance T1 mapping techniques were developed and tested to improve identification of RV interstitial cardiac fibrosis in rTOF. Multi-echo imaging to separate fat from myocardium, combined with blood signal suppression is promising as a feasible method in saturation-recovery T1 mapping, but requires further technical study prior to clinical application and validation. The genomic signatures of the pathological RV in rTOF were investigated by next generation RNA sequencing. Differential gene expression was evident, and potential molecular determinants of fibrotic and restrictive phenotypes were ascertained. Ubiquitin C may have important functional implications as a ‘network hub’ gene in rTOF. Finally, the longitudinal predictive role of neurohormone expression in patients with rTOF was examined. Neurohormonal activation was confirmed in rTOF, with serum brain natriuretic peptide being prognostic for mortality and sustained arrhythmias during extended follow-up. In conclusion, this work reflects the complex interplay of candidate biomarkers in influencing clinical outcomes. Myocardial fibrosis in rTOF remains a key diagnostic and therapeutic target for improving risk stratification and ameliorating morbidity in the lifelong care of these individuals.
Additional file 12: of Bivariate genome-wide association analysis strengthens the role of bitter receptor clusters on chromosomes 7 and 12 in human bitter taste
Creators: name: Liang-Dar Hwang
name: Puya Gharahkhani
name: Breslin, Paul
name: Gordon, Scott
name: Zhu, Gu
name: Martin, Nicholas
name: Reed, Danielle
name: Wright, Margaret
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Figure S3. Univariate GWAS for the perception of PROP paper from our previous GWAS of 1756 Australian adolescents. A Manhattan plot displays the association P-value for each SNP in the genome (displayed as â log10 of the P-value). This figure is the Fig. 1b from our previous published paper (PMID: 20675712). (DOCX 292 kb)
Probing a quantum spin liquid with equilibrium and nonequilibrium hole dynamics
Creators: name: Nyhegn, J. H.
name: Nielsen, K. Knakkergaard
name: Bruun, G. M.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The properties and experimental identification of quantum spin liquids (QSLs) remain an important topic with many fundamental questions. Here, we explore the dynamics of a single charge dopant (hole) in a $t$-$J_{1}$-$J_{2}$ model on a square lattice, which realizes a gapless $\mathbb{Z}_2$ QSL at half filling. Using a field theory approach based on the parton construction, which includes an infinite number of scatterings between the low-energy quasiparticle excitations of the QSL via a self-consistent Born approximation, we calculate both the equilibrium and nonequilibrium properties of the hole for weak and strong interactions. Quasiparticle branches as well as stringlike excitations of the holon are identified, and we furthermore explore the time-dependent spreading of a hole throughout the QSL after it has been injected at a given lattice site. The final ballistic expansion speed is shown to exhibit a nonmonotonic behavior as a quantum phase transition between an antiferromagnetic and the QSL phase is crossed, which is caused by a qualitative change in the fundamental kinematics of the interactions between the hole and the surrounding spins. Our results demonstrate how charge dopants can be used as a quantum probe for QSLs and are directly relevant to optical lattice experiments with single site resolution.
Risk of COVID-19 infection among prison staff in the United States
Creators: name: Seide, K.
name: Brinkley-Rubinstein, L.
name: Nowotny, K.M.
Publisher: name: BioMed Central Ltd
Year: 2021

description: Background: Multiple large outbreaks of COVID-19 have been documented in prisons and jails across regions of the world, with hazardous environmental conditions amplify the risks of exposure for both incarcerated people and correctional staff. The objectives of this study are to estimate the cumulative prevalence of COVID-19 cases among U.S. prison staff over time and compare it to the prison inmate population and the general U.S. population, overall, and to examine risk of COVID-19 infection among prison staff across jurisdictions. Methods: We use publicly available data (April 22, 2020 to January 15, 2021) to estimate COVID-19 crude case rates per 1000 with 95% confidence intervals over the study period for prison staff, incarcerated population, and general population. We also compare COVID-19 case rates between prison staff and the general population within jurisdictions. Results: Over the study period, prison staff have reported consistently higher rates of COVID-19 compared to the general population, with prison staff case rates more closely mirroring the incarcerated population case rates. The rolling 7-day average case rates for prison staff, prison population, and general population on January 15, 2021 were 196.04 per 1000 (95%CI 194.81, 197.26), 219.16 (95%CI 218.45, 219.86), and 69.80 (95%CI 69.78, 69.83), respectively. There was substantial heterogeneity across jurisdictions, yet in 87% of study jurisdictions, the risk of COVID-19 was significantly greater among prison staff than the general state population. Conclusions: Targeting staff for COVID-19 mitigation strategies is essential to protect the health of people who intersect with the correctional system and to flatten the curve in the surrounding communities.
Analytical Insights on Hadronic Top Quark Polarimetry
Creators: name: Dong, Zhongtian
name: Gonçalves, Dorival
name: Kong, Kyoungchul
name: Larkoski, Andrew J.
name: Navarro, Alberto
Publisher: name: arXiv
Year: 2024
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Top quark polarization provides an important tool for studying its production mechanisms, spin correlations, top quark properties, and new physics searches. Unlike lighter quarks, the top quark's polarization remains intact until its decay, enabling precise spin measurements. While the down-type fermions from $W$ boson decay are known to be effective spin analyzers, charged leptons have typically been the main target for most analyses. In this paper, we investigate the relevance of global jet dynamics -- considering kinematics, jet charges, and particle multiplicity -- for hadronic top quark polarimetry. The formalism used allows for analytical derivations obtained throughout the manuscript, offering deeper insights into the corresponding phenomenology.
description: 14 pages and 3 figures
title: ADCO, Ordre cistercien : comptes (1499-1515) (11 H 1162), f. 00066
Creators: name: de la Côte-d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: comptes
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Ordre cistercien : comptes (1499-1515), Archives départementales de la Côte-d'Or, (11 H 1162). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Ordre cistercien : comptes (1499-1515), Archives départementales de la Côte-d'Or, (11 H 1162), f. 00066, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Anas galericulata Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Aves
Anseriformes
Anatidae
Anas
Anas galericulata

description: Anas galericulata [spec. nov.]
A. crista dependente, dorsoque postico utrinque penna recurvata compressa elevata.
Auerquedula sinensis elegans. Edw. av. 102, t. 102.
Kinmodsuis. Kaemph. jap. 129. t. 10.
Habitat in China.
Crista viridis rubraque. Rostrum & Pedes rubri. Dorsum fuscum maculis caeruleis. Pennae dorsi erectae rufae obtusae. Remex intimus, clausis alis, altero margine erigitur supra dorsum, rufus, antrorsum falcatus.
* * * * Cristatae.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 128, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Evaluation of the impact of reservoir heterogeneity and mixing on low salinity waterflooding
Creators: name: Attar, Ahmed Zakariya
Publisher: name: Imperial College London
Year: 2017

description: This study investigated the impact of reservoir heterogeneity and physical diffusion/dispersion on low salinity waterflooding (LSW) using detailed numerical simulation. Two different methods for modelling the impact of LSW on relative permeability and hence on recovery were investigated: the salinity threshold model (ECLIPSE and STARS) and the ion exchange model (GEM). These simulators were validated by comparing their predictions with the analytical solution for immediate LSW. Physical diffusion/dispersion were characterized using the dimensionless transverse dispersion number (NTD) which was shown to be a robust measure for determining their impacts on the performance of LSW. The impact of numerical diffusion was evaluated for a range of grid resolutions and a correlation developed for estimating the maximum physical longitudinal dispersion that can be captured for a given grid resolution. The impact of transverse numerical diffusion was found to be very small. On laboratory scales, it was found that diffusion improves the oil recovery in layered high net-to-gross models but reduces the effectiveness of continuous LSW in models containing a thick shale filled with connate water. On the reservoir scale, the effect of dispersion on LSW was found to be minor compared with reservoir heterogeneity. The adverse effect of an aquifer was found to be most significant during the production of the connate water bank. If low salinity water is injected immediately as a slug, it was found that the best slug size is around 0.4-0.6 PV assuming a total water injection of 1 PV. If it is injected after a conventional water flood then the slug size increases to 1.3 PV assuming a total water injection of 2 PV. Finally, an analytical pseudoization method was proposed to upscale LSW by modifying Hearn’s method for layered reservoirs to include the connate water bank. This method was shown to give improved predictions over those obtained by the original Hearn’s method when compared using a 2D layered model.
Polytropic gas spheres: An approximate analytic solution of the Lane-Emden equation
Creators: name: Liu, F. K.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Polytropic models play a very important role in galactic dynamics and in the theory of stellar structure and evolution. However, in general, the solution of the Lane-Emden equation can not be given analytically but only numerically. In the Lane-Emden equation can not be given analytically but only numerically. In this paper we give a very good and simple analytic approximate solution of the Lane-Emden equation. This approximation is very good for any finite polytropic index $n$ and for the isothermal case (n equals infinity) at a level $<1\%$. We also give analytic expressions of the mass, pressure, temperature, and potential energy as a function of radius.
description: 16 pages, plain tex file, five figures
Additional file 1: of Longitudinal monitoring of Culicoides in Belgium between 2007 and 2011: local variation in population dynamics parameters warrant cautious use of monitoring data
Creators: name: Sohier, Charlotte
name: Isra Deblauwe
name: Deken, Reginald De
name: Madder, Maxime
name: Fassotte, Christiane
name: Losson, Bertrand
name: Regge, Nick De
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Table S1. Location, sampling period, local ecological factors in the immediate vicinity of the collection site and eco-region with its characteristic ecological aspects for all 7 collection sites. (DOCX 14 kb)
Theory of viscous remanent magnetization acquisition and its application to flood dating
Creators: name: Berndt, Thomas
Publisher: name: Imperial College London
Year: 2016

description: Most rocks contain magnetic minerals that acquire a natural remanent magnetization (NRM) in the direction of the geomagnetic field during their formation. Floods may quarry, transport and rotate boulders such that their NRM will subsequently be randomly aligned. The magnetic minerals then gradually acquire a viscous remanent magnetization (VRM) at ambient temperatures in the direction of the ambient field that partially overprints the original NRM. According to Néel's (1949) theory of fine magnetic particles, the demagnetization temperature of a VRM is a function of acquisition time and can be used to date the movement of the rock and, hence, the flood. No generally accepted standard method of VRM dating exists yet. In this thesis, a theory of VRM acquisition is rigorously derived and experimentally tested, including heating/cooling rate effects, temperaturedependence of the attempt time, and the effect of mixtures of magnetic minerals. A protocol for VRM flood dating based on continuous thermal demagnetization (CTD) of flood boulders is proposed and evaluated on five cases of known ages: three jökulhlaups in Iceland (Sólheimajökull, Kotarjökull and Markarfljot), a storm flood deposit in Scotland, and a tsunami in Cape Verde. The protocol encompasses sampling procedure, CTD of the NRM, magnetic viscosity experiments, criteria for sample selection and a full statistical treatment of the obtained age estimates and uncertainties. Two Icelandic dating attempts were successful, while the remaining three attempts were unsuccessful, but were clearly identifed as such. In the two successful cases gave a good agreement with known ages of 72 years (error limits 11-360 years) versus a known age of 155 years for the Sólheimajökull flood and 290 years (error limits 80-2300 years) versus a known age of 288 years for the Kotarjökull flood. This suggests that CTD of VRMs can be a useful order-of-magnitude tool for flood dating.
Coagulation and wound repair during COVID-19
Creators: name: Gralinski, Lisa E.
name: Menachery, Vineet D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: While COVID-19 is best known as a respiratory infection, SARS-CoV-2 causes systemic disease manifestations including coagulopathies. Both dysregulated extracellular matrix remodeling pathways and circulating coagulation proteins are hallmarks of severe COVID-19 and often continue after the resolution of acute infection. Coagulation proteins have proven effective as biomarkers for severe disease and anti-coagulants are a mainstay of COVID-19 therapeutics in hospitalized patients. While much knowledge has been gained about the role of clotting pathway activation in COVID-19, much remains to be elucidated in this complex network of signaling pathways.
Performance analysis of mobile networks under signalling storms
Creators: name: Pavloski, Mihajlo
Publisher: name: Imperial College London
Year: 2017

description: There are numerous security challenges in cellular mobile networks, many of which originate from the Internet world. One of these challenges is to answer the problem with increasing rate of signalling messages produced by smart devices. In particular, many services in the Internet are provided through mobile applications in an unobstructed manner, such that users get an always connected feeling. These services, which usually come from instant messaging, advertising and social networking areas, impose significant signalling loads on mobile networks by frequent exchange of control data in the background. Such services and applications could be built intentionally or unintentionally, and result in denial of service attacks known as signalling attacks or storms. Negative consequences, among others, include degradations of mobile network’s services, partial or complete net- work failures, increased battery consumption for infected mobile terminals. This thesis examines the influence of signalling storms on different mobile technologies, and proposes defensive mechanisms. More specifically, using stochastic modelling techniques, this thesis first presents a model of the vulnerability in a single 3G UMTS mobile terminal, and studies the influence of the system’s internal parameters on stability under a signalling storm. Further on, it presents a queueing network model of the radio access part of 3G UMTS and examines the effect of the radio resource control (RRC) inactivity timers. In presence of an attack, the proposed dynamic setting of the timers manage to lower the signalling load in the network and to increase the threshold above which a network failure could happen. Further on, the network model is upgraded into a more generic and detailed model, represent different generations of mobile technologies. It is than used to compare technologies with dedicated and shared organisation of resource allocation, referred to as traditional and contemporary networks, using performance metrics such as: signalling and communication delay, blocking probability, signalling load on the network’s nodes, bandwidth holding time, etc. Finally, based on the carried analysis, two mechanisms are proposed for detection of storms in real time, based on counting of same-type bandwidth allocations, and usage of allocated bandwidth. The mechanisms are evaluated using discrete event simulation in 3G UMTS, and experiments are done combining the detectors with a simple attack mitigation approach.
The broad-band power spectra of X-ray binaries
Creators: name: Wijnands, Rudy
name: van der Klis, Michiel
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We analyzed the rapid aperiodic X-ray variability of different types of X-ray binaries (black hole candidates, atoll sources, the recently discovered millisecond X-ray pulsar, and Z sources) at their lowest inferred mass accretion rates. At these accretion rates, the power spectra of all sources are dominated by a strong band-limited noise component, which follows a power law with an index roughly 1 at high frequencies and breaks at a frequency between 0.02 and 32 Hz below which the spectrum is relatively flat. Superimposed on this, a broad bump (sometimes a quasi-periodic oscillation) is present with a 0.2-67 Hz centroid frequency that varies in good correlation with the frequency of the break. The black hole candidates and the low-luminosity neutron star systems (including the millisecond X-ray pulsar) have the same relation between the frequency of the bump and the frequency of the break. These similar characteristics strongly suggest that in all those different types of sources the band-limited noise and the bump are produced by the same physical mechanism. This mechanism cannot then depend on the presence or absence of either a small magnetosphere or a solid surface, so that it is most likely related to an instability in the flow in the accretion disk that modulates the accretion rate. The Z sources, which are more luminous than the other sources discussed here, follow a similar, but slightly shifted correlation between the break frequency and the frequency of the bump. The data suggest that the band-limited noise in Z sources is more complex than that in the other sources.
description: 10 pages, 3 figures (of which one a color figure). Accepted for publication in Astrophysical Journal Part 1
Immunogenicity of Ad26.COV2.S vaccine against SARS-CoV-2 variants in humans
Creators: name: Le Gars, Mathieu
name: Stephenson, Kathryn E.
name: Yu, Jingyou
name: Chang, Aiquan
name: van Hoof, Johan
name: Shin, Sally
name: Chandrashekar, Abishek
name: Jacob-Dolan, Catherine
name: Anioke, Tochi
name: Heerwegh, Dirk
name: de Groot, Anne Marit
name: Douoguih, Macaya
name: Lifton, Michelle
name: Nkolola, Joseph
name: Alter, Galit
name: Robins, Harlan
name: Amanat, Fatima
name: Struyf, Frank
name: Atyeo, Caroline
name: Sadoff, Jerald
name: Martinez, David R.
name: Fields, Paul
name: Borducchi, Erica N.
name: Baric, Ralph S.
name: Kaplan, Ian
name: McMahan, Katherine
name: Liu, Jinyan
name: Barouch, Dan H.
name: Krammer, Florian
name: Schuitemaker, Hanneke
name: Tostanoski, Lisa H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: The Ad26.COV2.S vaccine1–3 has demonstrated clinical efficacy against symptomatic COVID-19, including against the B.1.351 variant that is partially resistant to neutralizing antibodies1. However, the immunogenicity of this vaccine in humans against SARS-CoV-2 variants of concern remains unclear. Here we report humoral and cellular immune responses from 20 Ad26.COV2.S vaccinated individuals from the COV1001 phase 1/2 clinical trial2 against the original SARS-CoV-2 strain WA1/2020 as well as against the B.1.1.7, CAL.20C, P.1., and B.1.351 variants of concern. Ad26.COV2.S induced median pseudovirus neutralizing antibody titers that were 5.0- and 3.3-fold lower against the B.1.351 and P.1 variants, respectively, as compared with WA1/2020 on day 71 following vaccination. Median binding antibody titers were 2.9- and 2.7-fold lower against the B.1.351 and P.1 variants, respectively, as compared with WA1/2020. Antibody-dependent cellular phagocytosis, complement deposition, and NK cell activation responses were largely preserved against the B.1.351 variant. CD8 and CD4 T cell responses, including central and effector memory responses, were comparable among the WA1/2020, B.1.1.7, B.1.351, P.1, and CAL.20C variants. These data show that neutralizing antibody responses induced by Ad26.COV2.S were reduced against the B.1.351 and P.1 variants, but functional non-neutralizing antibody responses and T cell responses were largely preserved against SARS-CoV-2 variants. These findings have implications for vaccine protection against SARS-CoV-2 variants of concern.
On the Spectral Slopes of Hard X-ray Emission from Black Hole Candidates
Creators: name: Ebisawa, Ken
name: Titarchuk, Lev G.
name: Chakrabarti, Sandip K.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Most black hole candidates exhibit characteristic power-law like hard X-ray emission above $\sim$ 10 keV. In the {\em high state}, in which 2 -- 10 keV luminosity is relatively high, the energy index of the hard X-ray emission is usually greater than 1 --- typically $\sim 1.5$. On the other hand, in the {\em low state}, the hard X-ray energy index is 0.3 -- 0.9. In this paper, we suggest that this difference of the hard X-ray spectral slopes may be due to two different Comptonization mechanisms. We propose that, in the high state, the hard component is governed by the Comptonization due to the bulk motion of the almost freely falling (convergent accretion) flow close to the black hole, rather than thermal Comptonization. The spectral slope of the hard component is insensitive to the disk accretion rate governing the soft component, hence is nearly invariant in spite of the soft component variations. The power-law component due to the bulk motion Comptonization has a sharp cut-off at around the electron rest mass energy, which is consistent with high energy observations of the high state. In the low state, the spectrum is formed due to thermal Comptonization of the low-frequency disk radiation by a sub-Keplerian component (possibly undergoing a centrifugally-supported shock) which is originated from the Keplerian disk. In the limit of low disk accretion rate, the power law index is uniquely determined by the mass accretion rate of the sub-Keplerian component.
description: 12 pages of text and Figures (tar compressed postscript file), To appear in PASJ, Feb. 96 (v. 48, No. 1)