Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma
Creators: name: Santibanez, Jireh
name: Robertson, A. Gordon
name: Meng, Shaowu
name: Pihl, Todd
name: Auman, J. Todd
name: Wilkerson, Matthew D.
name: Hoadley, Katherine A.
name: Bussey, Kimberly J.
name: Wu, Hsin-Ta
name: Crawford, Catherine
name: Sibony, Mathilde
name: Cope, Leslie M.
name: Arachchi, Harindra
name: Sander, Chris
name: Wang, Zhining
name: Gill, Anthony J.
name: Bodenheimer, Tom
name: Shinbrot, Eve
name: Mayo, Michael
name: Hu, Jianhong
name: Liu, Jia
name: Choueiri, Toni K.
name: Mills, Gordon B.
name: Davidsen, Tanja
name: Raphael, Benjamin J.
name: Balu, Saianand
name: Ciriello, Giovanni
name: Jones, Corbin D.
name: Guin, Ranabir
name: Hammer, Gary D.
name: Lerario, Antonio M.
name: Hoyle, Alan P.
name: Weisenberger, Daniel J.
name: Giordano, Thomas J.
name: Radenbaugh, Amie
name: Cho, Juok
name: Ling, Shiyun
name: Sofia, Heidi J.
name: Zhu, Jingchun
name: Wu, Junyuan
name: Khan, Ziad
name: Amble, Linda
name: Naresh, Rashi
name: Dousset, Bertrand
name: Shao, Lina
name: Shih, Juliann
name: Waldmann, Jens
name: Coppens, Sara
name: Lee, Darlene
name: Demchok, John A.
name: Doddapaneni, Harsha
name: Danilova, Ludmila
name: Wang, Wenyi
name: Mose, Lisle E.
name: Kim, Hoon
name: Beroukhim, Rameen
name: Morgan, Margaret
name: Wan, Yunhu
name: Hutter, Carolyn M.
name: Kovar, Christine
name: Latronico, Ana Claudia
name: Rao, Arjun
name: Marra, Marco A.
name: Knijnenburg, Theo A.
name: Almeida, Madson Q.
name: Ju, Zhenlin
name: Sougnez, Carrie
name: Kroiss, Matthias
name: Shi, Yan
name: Wu, Ye
name: Shmulevich, Ilya
name: Gaudioso, Carmelo
name: Akbani, Rehan
name: Mungall, Karen
name: Felau, Ina
name: Schein, Jacqueline E.
name: Gibbs, Richard
name: Morozova, Olena
name: Moffitt, Richard A.
name: Weinstein, John N.
name: Fragoso, Maria C.B.V.
name: Verhaak, Roel G.W.
name: Dewal, Ninad
name: Soloway, Matthew G.
name: Kalra, Divya
name: Lawrence, Michael S.
name: Defreitas, Timothy
name: Ronchi, Cristina
name: Kasaian, Katayoon
name: Park, Peter J.
name: Demeure, Michael J.
name: Hayes, D. Neil
name: Herman, James G.
name: Parker, Joel S.
name: Morton, Donna
name: Reincke, Martin
name: Han, Yi
name: Lee, Sandy
name: Sanborn, Zack
name: Wheeler, David A.
name: Xi, Liu
name: Lim, Lynette
name: Soon, Patsy
name: Leraas, Kristen M.
name: Zmuda, Erik
name: Buhay, Christian
name: Benz, Christopher
name: Bowlby, Reanne
name: Liu, Wenbin
name: Fan, Yu
name: Cherniack, Andrew D.
name: Bootwalla, Moiz S.
name: Hawes, Alicia
name: Mendonca, Berenice B.
name: Sidhu, Stan B.
name: Noble, Michael S.
name: Alonso, Shelley
name: Van Den Berg, David J.
name: Raman, Rohini
name: Bshara, Wiam
name: Murray, Bradley A.
name: Zenklusen, Jean C.
name: Laird, Peter W.
name: Beuschlein, Felix
name: Carter, Scott L.
name: Tarnuzzer, Roy
name: Schumacher, Steven E.
name: Gerken, Mark
name: Saksena, Gordon
name: Kim, Seungchan
name: Else, Tobias
name: Allolio, Bruno
name: Sun, Qiang
name: Mungall, Andrew J.
name: Jefferys, Stuart R.
name: Zheng, Siyuan
name: Frazer, Scott
name: Gao, Jianjiong
name: Morrison, Carl
name: Lin, Pei
name: Butterfield, Yaron S.N.
name: Lai, Phillip H.
name: Groussin, Lionel
name: Raymond, Victoria M.
name: Ma, Yussanne
name: Bertherat, Jérôme
name: Meier, Sam
name: Gabriel, Stacey B.
name: Mieczkowski, Piotr A.
name: Meyerson, Matthew
name: Lu, Yiling
name: Zhang, Jiashan
name: Whitsett, Timothy G.
name: Yeh, Jen Jen
name: Brooks, Denise
name: Dhalla, Noreen
name: Perou, Charles M.
name: Roach, Jeffrey
name: Libé, Rossella
name: Rainey, William E.
name: Ladanyi, Marc
name: Thiessen, Nina
name: Lolla, Laxmi
name: Wang, Qianghu
name: Holt, Robert A.
name: Tam, Angela
name: Zhang, Wei
name: Watanabe, Aprill
name: Moore, Richard A.
name: Reynolds, Sheila
name: Baylin, Stephen
name: Chudamani, Sudha
name: Simons, Janae V.
name: Zhang, Hailei
name: Asa, Sylvia L.
name: Lichtenberg, Tara M.
name: Quinkler, Marcus
name: Ramirez, Nilsa C.
name: Hale, Walker
name: Voet, Doug
name: Bowen, Jay
name: Chin, Lynda
name: Bartsch, Detlef K.
name: Sadeghi, Sara
name: Getz, Gad
name: Covington, Kyle
name: Wise, Lisa
name: Veluvolu, Umadevi
name: Li, Haiyan I.
name: Sipahimalani, Payal
name: Sheth, Margi
name: Fassnacht, Martin
name: Carlsen, Rebecca
name: Gastier-Foster, Julie M.
name: Haussler, David
name: Baboud, Julien
name: Tan, Donghui
name: Yoshihara, Kosuke
name: Habra, Mouhammed A.
name: Kucherlapati, Raju
name: Muzny, Donna
name: Kim, Jaegil
name: Sbiera, Silviu
name: Downs, Brittany
name: Drummond, Jennifer
name: Yang, Liming
name: Schultz, Nikolaus
name: Deutschbein, Timo
name: Ally, Adrian
name: Dinh, Huyen
name: Balasundaram, Miruna
name: Sircar, Kanishka
name: Kakkar, Nipun
name: Helsel, Carmen
name: Lewis, Lora
name: Kebebew, Electron
name: Jones, Steven J.M.
name: Dahdouli, Mahmoud
name: Heiman, David I.
name: Robinson, Bruce
name: LoBello, Janine
name: Shaw, Kenna R. Mills
name: Mete, Ozgur
name: Vinco, Michelle
name: Assie, Guillaume
name: Bellair, Michelle
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: SummaryWe describe a comprehensive genomic characterization of adrenocortical carcinoma (ACC). Using this dataset, we expand the catalogue of known ACC driver genes to include PRKAR1A, RPL22, TERF2, CCNE1, and NF1. Genome wide DNA copy-number analysis revealed frequent occurrence of massive DNA loss followed by whole-genome doubling (WGD), which was associated with aggressive clinical course, suggesting WGD is a hallmark of disease progression. Corroborating this hypothesis were increased TERT expression, decreased telomere length, and activation of cell-cycle programs. Integrated subtype analysis identified three ACC subtypes with distinct clinical outcome and molecular alterations which could be captured by a 68-CpG probe DNA-methylation signature, proposing a strategy for clinical stratification of patients based on molecular markers.