title: ÐÐ·ÑÑÐµÐ½Ð¸Ðµ Ð°Ð½ÑÐ¸Ð¼Ð¸ÐºÑÐ¾Ð±Ð½ÑÑ ÑÐ²Ð¾Ð¹ÑÑÐ² Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´Ð½ÑÑ ÑÐ¼Ð¾Ð»ÑÐ½ÑÑ ÐºÐ¸ÑÐ»Ð¾Ñ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Study of the antimicrobial properties of resin acid derivatives
Creators: name: Ð¢Ð°Ð½ Ð§Ð¶Ð¸Ñ ÑÑÐ¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: Ð°Ð½ÑÐ¸Ð¼Ð¸ÐºÑÐ¾Ð±Ð½Ð°Ñ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ
ÑÐ¼Ð¾Ð»ÑÐ½ÑÐµ ÐºÐ¸ÑÐ»Ð¾ÑÑ
ÑÐ°Ð»Ð»Ð¾Ð²Ð°Ñ ÐºÐ°Ð½Ð¸ÑÐ¾Ð»Ñ
ÑÑÐµÑÐ¸ÑÐ¸ÐºÐ°ÑÐ¸Ñ
antimicrobial activity
resin acids
tall oil rosin
esterification

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description: This work is devoted to the study of antimicrobial properties of new derivatives of resin acids - polyfluorosubstituted esters of N-phenylimide of maleopymaric acid. Tasks that were solved during the study: 1) Selection of research objects: N-phenylimide 2,2,2,3,3,4,4,5,5-octafluoropentylmaleopimarate and N-phenylimide 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoroheptylmaleopimarate, bacteria (Escherichia coli, Bacillus subtilis) and yeast (Saccharomyces boulardii, Candida tropicalis, Rhodotorula rubra). 2) Synthesis of polyfluorosubstituted esters of N-phenylimide of maleopymaric acid. 3) Preparation of nutrient medium. 4) Incubation of microorganisms used in the work.Â 5) Preparation of polyfluorosubstituted esters of N-phenylimide of maleopymaric acid. 6) Determination of antimicrobial properties of the studied compounds. 7) Calculation of biological activity of compounds using Pass online software package. This thesis was carried out in the laboratory of organic chemistry of the Graduate School of Biotechnology and Food Production, Peter the Great St. Petersburg Polytechnic University. This work is devoted to the determination of bioactive action of new polyfluoroalkyl derivatives of maleopymaric acid and their N-phenylimides against yeast and bacteria cells. A study of the antimicrobial properties of N-phenylimide 2,2,3,3,4,4,5,5-octafluoropentylmaleopimarate and N-phenylimide 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluorheptylmaleopimarate revealed that N-phenylimide 2,2,2,3,3,4,4,5,5-octafluoropentylmaleopimarate inhibits the yeasts Saccharomyces boulardii and Rhodotorula rubra and has no inhibitory effect on Escherichia coli and Bacillus subtilis bacteria cells. N-Phenylimide 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoroheptylmaleopimarate inhibits the growth of Bacillus subtilis bacteria but does not cause cell death in Escherichia coli and shows no activity against Candida tropicalis, Saccharomyces boulardii and Rhodotorula rubra yeast cells. The ability of N-phenylimide 2,2,3,3,4,4,5,5-octafluoropentylmaleopimarat to inhibit the yeasts Rhodotorula rubra and Saccharomyces boulardii was found to increase with increasing concentration, while yeast inhibition did not increase after reaching a concentration of 25 mg/ml.Â Â