cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Patterns of drinking in Aboriginal and Torres Strait Islander peoples as self-reported on the Grog Survey App: a stratified sample
Creators: name: Lee, Kylie
name: Conigrave, James H
name: Wilson, Scott
name: Perry, Jimmy
name: Hayman, Noel
name: Zheng, Catherine
name: Ansari, Mustafa Al
name: Doyle, Michael
name: Room, Robin
name: Callinan, Sarah
name: Chikritzhs, Tanya
name: Slade, Tim
name: Conigrave, Katherine M
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: BACKGROUND: The Grog Survey App is a visual and interactive tablet computer-based survey application. It has been shown to be an accurate and acceptable tool to help Indigenous Australians describe what they drink. METHODS: The Grog Survey App was used to enquire into patterns of drinking in a stratified sample of Indigenous Australians in urban and remote/regional sites during testing of the App. The App asked about the last four drinking occasions in the past 12 months, including preferred alcohol types and containers; and symptoms of alcohol dependence, based on ICD-11 descriptions. Drinking patterns are presented here using medians and interquartile ranges, and the thresholds set out by the Australian National and Health and Medical Research Council guidelines. Patterns of consumption are compared by gender and remoteness, using Wilcoxon rank-sum test to compare medians. Logistic regressions tested whether alcohol types and drinking containers varied by remoteness. RESULTS: In this stratified sample most people either consumed nothing (21.7%), or consumed quantities which placed them at short- (95.6%) or long-term risk (47.8%) of harms. Drinkers in remote areas were more likely to drink beer, but less likely to drink pre-mixed spirits. 'Stubbies' and other beer glasses were popular in urban areas, compared with 'slabs' (cases of beer) in remote/regional areas. The use of improvised containers (i.e. empty juice bottles) did not vary by remoteness. Nearly one in six (15%) current drinkers reported experiencing at least two symptoms of alcohol dependence at least monthly. Average drinks per day was the consumption measure most highly correlated with each dependence symptom (r = 0.34-0.38). CONCLUSIONS: The App was able to capture a wide range of preferred alcohol types and containers, and demonstrate a diversity in how alcohol is consumed. This detail was captured in a relative brief survey delivered using an interactive and appealing tablet computer-based application.
Policy brief: Puustoisesta maataloudesta hyötyä Suomen maataloudelle - Mitä puustoinen maatalous tarkoittaa Suomessa?
Creators: name: Mattila, Iiris
name: den Herder, Michael
name: Lilja, Saara
name: Mantere, Noora
name: Ajosenpää, Terhi
name: Koskinen, Kukka
name: Hirvonen, Auli
Publisher: name: Zenodo
Year: 2024
Subjects: subject: puustoinen maatalous
subject: Common agricultural policy
subject: Agroforestry
subject: Finland
subject: agrometsätalous
subject: peltometsäviljely

description: Puustoisessa maataloudessa (agroforestry, myös suom. agrometsätalous) hyödynnetään puuvartisia kasveja osana maataloutta. Se on aina suunnitelmallista ja monihyötyistä, eli sillä ei tarkoiteta peltojen umpeenkasvua. Puustoinen maatalous monipuolistaa maatilojen tuotantorakennetta, minkä lisäksi sen avulla voidaan lisätä luonnon monimuotoisuutta ja hiilensidontaa maaperään sekä vähentää ravinnehuuhtoutumia vesistöihin. Hyvin suunniteltu agrometsätalousjärjestelmä lisää maatilan resilienssiä sää- ja ilmastoriskejä vastaan ja siten parantaa ruuantuotannon huoltovarmuutta. Puustoisen maatalouden menetelmiä voidaan myös hyödyntää osana ennallistamisen toimeenpanoa. Puustoisen maatalouden menetelmiä hyödynnetään muissa EU:n jäsenmaissa huomattavasti laajemmin kuin Suomessa. Puustoinen maatalous Suomessa -kirja on koostanut tutkimus- ja käytännön tietoa yhteen, mutta aiheesta tarvitaan lisää koulutusmateriaalia viljelijöille ja neuvojille sekä osallistavaa keskustelua, jotta aihe ymmärretään.
Safety and immunogenicity of a third-dose homologous BBIBP-CorV boosting vaccination: interim results from a prospective open-label study
Creators: name: Ai, Jingwen
name: Zhang, Yi
name: Zhang, Haocheng
name: Zhang, Qiran
name: Fu, Zhangfan
name: Lin, Ke
name: Song, Jieyu
name: Zhao, Yuanhan
name: Fan, Mingxiang
name: Wang, Hongyu
name: Zhou, Yang
name: Chen, Xiaohua
name: Qiu, Chao
name: Zhang, Wenhong
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: A COVID-19 booster vaccination is being comprehensively evaluated globally due to the emerging concern of reduced protection rate of previous vaccination and circulating Variants of Concern (VOC). But the safety and immunogenicity of homologous BBIBP-CorV boosting vaccination are yet to be thoroughly evaluated. We conducted this prospective, open-label study in Huashan Hospital using a third 6.5U BBIBP-CorV administered at an interval of 4–8 months following the previous two doses in healthy adults. Safety, anti-RBD response and neutralizing titers against SARS-CoV-2 and VOCs were examined. Sixty-three and forty participants entered the booster and the control group, respectively. A significant increase in IFN-γ SFU per million PBMCs was observed on day 14 against N peptide (20 vs. 5, P < 0.001). On day 14, pVNT GMTs increased over 15 folds of the baseline levels against prototype to reach 404.54 titers and over 9–13 folds against 4 VOCs and continuously increased by day 28. sVNT GMTs increased 112.51 and 127.45 folds by days 14 and 28 compared to the baseline level. Median anti-RBD antibody and IgG level significantly increased from 11.12 to 2607.50 BAU/ml and 4.07 to 619.20 BAU/ml on day 14. On day 14, females showed a significantly higher cell-mediated immune response against S1 peptide. The 7–8 months interval group had a higher humoral response than the 4–6 months interval group. No severe adverse event was reported. A third homologous BBIBP-CorV boosting vaccination was safe and highly immunogenic for healthy adults and broadened participants’ immunity against VOCs.
Additional file 1 of Transcriptionally imprinted glycomic signatures of acute myeloid leukemia
Creators: name: Blöchl, Constantin
name: Wang, Di
name: Mayboroda, Oleg A.
name: Lageveen-Kammeijer, Guinevere S. M.
name: Wuhrer, Manfred
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Figure S1. GST and TF expression across FAB subtypes. Expression of selected GSTs and TFs was explored in primary AML blasts. Significances were assessed by one-way ANOVA followed by a Tukey post-hoc test. Significant values are marked with * (p ≤ 0.05), ** (p ≤ 0.01), *** (p ≤ 0.001), and **** (p ≤ 0.0001).
Patterns of drinking in Aboriginal and Torres Strait Islander peoples as self-reported on the Grog Survey App: a stratified sample
Creators: name: Lee, Kylie
name: Conigrave, James
name: Wilson, Scott
name: Perry, Jimmy
name: Hayman, Noel
name: Zheng, Catherine
name: Ansari, Mustafa Al
name: Doyle, Michael
name: Room, Robin
name: Callinan, Sarah
name: Chikritzhs, Tanya
name: Slade, Tim
name: Conigrave, Katherine M
Publisher: name: La Trobe
Year: 2024

description: BACKGROUND: The Grog Survey App is a visual and interactive tablet computer-based survey application. It has been shown to be an accurate and acceptable tool to help Indigenous Australians describe what they drink. METHODS: The Grog Survey App was used to enquire into patterns of drinking in a stratified sample of Indigenous Australians in urban and remote/regional sites during testing of the App. The App asked about the last four drinking occasions in the past 12 months, including preferred alcohol types and containers; and symptoms of alcohol dependence, based on ICD-11 descriptions. Drinking patterns are presented here using medians and interquartile ranges, and the thresholds set out by the Australian National and Health and Medical Research Council guidelines. Patterns of consumption are compared by gender and remoteness, using Wilcoxon rank-sum test to compare medians. Logistic regressions tested whether alcohol types and drinking containers varied by remoteness. RESULTS: In this stratified sample most people either consumed nothing (21.7%), or consumed quantities which placed them at short- (95.6%) or long-term risk (47.8%) of harms. Drinkers in remote areas were more likely to drink beer, but less likely to drink pre-mixed spirits. 'Stubbies' and other beer glasses were popular in urban areas, compared with 'slabs' (cases of beer) in remote/regional areas. The use of improvised containers (i.e. empty juice bottles) did not vary by remoteness. Nearly one in six (15%) current drinkers reported experiencing at least two symptoms of alcohol dependence at least monthly. Average drinks per day was the consumption measure most highly correlated with each dependence symptom (r = 0.34-0.38). CONCLUSIONS: The App was able to capture a wide range of preferred alcohol types and containers, and demonstrate a diversity in how alcohol is consumed. This detail was captured in a relative brief survey delivered using an interactive and appealing tablet computer-based application.
Experiences of caregivers of children with food allergy during the COVID‐19 pandemic
Creators: name: Dattilo, Taylor M.
name: Stutes, Shahan
name: MacDougall, Jessica
name: Atkinson, Dean
name: Tackett, Alayna P.
name: Virkud, Yamini V.
name: Carter, Carrick
name: Mullins, Larry L.
name: Roberts, Caroline M.
Publisher: name: Wiley
Year: 2023

description:
To the Editor,
Food allergy (FA) is an immune response to exposure to a given food allergen (e.g., egg, peanuts, and shellfish). In the United States,  approximately 4%–8% of children are diagnosed with pediatric FA and the prevalence continues to increase. In the Midwest United States, where this study was conducted, FA diagnoses have dramatically increased (e.g., 2009–2016; Indiana 133%, Kansas 79%, Michigan 179%, Ohio 169%, Oklahoma 215%) and children comprise greater percentages of FA insurance claims compared with older age groups (e.g., 2009–2016; Indiana 56%, Kansas 55%, Michigan 60%, Ohio 65%, Oklahoma 50%). Moreover, the effects of the COVID-19 pandemic on families with pediatric FA are not well understood. Repercussions of the COVID-19 pandemic for the general population include increasing rates of poverty and food insecurity, creating additional barriers and interruptions to healthcare, and amplifying complications of chronic disease. Because of the multitude of financial and healthcare access barriers during the COVID-19 pandemic, access to food may be compromised for families with FA and mealtime emphasis may shift from carefully assessing for food allergens to simply providing nutrition, thus increasing the risk for FA reactions.
Resistance profiling of Aspergillus fumigatus to olorofim indicates absence of intrinsic resistance and unveils the molecular mechanisms of acquired olorofim resistance
Creators: name: Buil, Jochem B.
name: Oliver, Jason D.
name: Law, Derek
name: Baltussen, Tim
name: Zoll, Jan
name: Hokken, Margriet W.J.
name: Tehupeiory-Kooreman, Marlou
name: Melchers, Willem J.G.
name: Birch, Mike
name: Verweij, Paul E.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Olorofim (F901318) is a new antifungal currently under clinical development that shows both in vitro and in vivo activity against a number of filamentous fungi including Aspergillus fumigatus. In this study we screened A. fumigatus isolates for intrinsic olorofim-resistant A. fumigatus and evaluated the ability of A. fumigatus to acquire an olorofim-resistant phenotype. No intrinsic resistance was found in 975 clinical A. fumigatus isolates. However, we found that isolates with increased olorofim MICs (> 8  mg/L) could be selected using a high number of conidia and olorofim exposure under laboratory conditions. Assessment of the frequency of acquired olorofim resistance development of A. fumigatus was shown to be higher than for voriconazole but lower than for itraconazole. Sequencing the PyrE gene of isogenic isolates with olorofim MICs of >8  mg/L identified various amino acid substitutions with a hotspot at locus G119. Olorofim was shown to have reduced affinity to mutated target protein dihydroorotate dehydrogenase (DHODH) and the effect of these mutations were proven by introducing the mutations directly in A. fumigatus. We then investigated whether G119 mutations were associated with a fitness cost in A. fumigatus. These experiments showed a small but significant reduction in growth rate for strains with a G119  V substitution, while strains with a G119C substitution did not exhibit a reduction in growth rate. These in vitro findings were confirmed in an in vivo pathogenicity model
Identification of the SARS-CoV-2 Delta variant C22995A using a high-resolution melting curve RT-FRET-PCR
Creators: name: Barua, Subarna
name: Bai, Jianfa
name: Kelly, Patrick John
name: Hanzlicek, Gregg
name: Noll, Lance
name: Johnson, Calvin
name: Yin, Ji-Hang
name: Wang, Chengming
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Knowledge of SARS-CoV-2 variants is essential for formulating effective control policies. Currently, variants are only identified in relatively small percentages of cases as the required genome sequencing is expensive, time-consuming, and not always available. In countries with facilities to sequence the SARS-CoV-2, the Delta variant currently predominates. Elsewhere, the prevalence of the Delta variant is unclear. To avoid the need for sequencing, we investigated a RT-FRET-PCR that could detect all SARS-CoV-2 strains and simultaneously identify the Delta variant. The established Delta RT-FRET-PCR was performed on reference SARS-CoV-2 strains, and human nasal swab samples positive for the Delta and non-Delta strains. The Delta RT-FRET-PCR established in this study detected as few as ten copies of the DNA target and 100 copies of RNA target per reaction. Melting points of products obtained with SARS-CoV-2 Delta variants (around 56.1°C) were consistently higher than products obtained with non-Delta strains (around 52.5°C). The Delta RT-FRET-PCR can be used to diagnose COVID-19 patients and simultaneously identify if they are infected with the Delta variant. The Delta RT-FRET-PCR can be performed with all major thermocycler brands meaning data on Delta variant can now be readily generated in diagnostic laboratories worldwide.
Addressing elder abuse through integrating law into health: What do allied health professionals at a Community Health Service in Melbourne, Australia, think?
Creators: name: Lewis, Virginia
name: White, Vanessa
name: Hawthorne, Faith
name: Eastwood, Jess
name: Mullins, Robyn
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2019 Justice Connect. Australasian Journal on Ageing published by John Wiley & Sons Australia, Ltd on behalf of AJA Inc. This research looked at the attitudes of Community Health Service (CHS) staff regarding the integration of a lawyer into their CHS both before and after the integration occurred. It assessed their confidence in identifying and addressing elder abuse at each point. A written survey was distributed to staff before the lawyer commenced (n = 126), and approximately 12 months afterwards (n = 54). The preliminary survey demonstrated widespread agreement that legal issues can affect older people and supported having a lawyer in a CHS. Respondents were not confident about their capacity to identify abuse and provide referrals to a lawyer, but this improved in the follow-up survey. These CHS staff were aware of the potential impacts of elder abuse and supported embedding a lawyer in the health service. Information and training as part of this service model should focus on the skills needed for CHS staff to play their role in such a partnership.
From Unknown Unknowns to Known Unknowns: A product of digitisation is a better understanding of the causes of collection loss
Creators: name: Walcott, Rachel
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference oral presentation on From Unknown Unknowns to Known Unknowns: A product of digitisation is a better understanding of the causes of collection loss by Principal Curator Rachel Walcott of Principal Curator National Museums Scotland Edinburgh United Kingdom for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
The capacity for estrogen to influence obesity through brown adipose tissue (BAT) thermogenesis in animal models: A systematic review and meta‐analysis
Creators: name: Sievers, William
name: Rathner, Joseph A
name: Kettle, Christine
name: Zacharias, Anita
name: Irving, Helen
name: Green, Rodney
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2019 The Authors. Obesity Science & Practice published by World Obesity and The Obesity Society and John Wiley & Sons Ltd Pharmacological interventions to aid weight loss have historically targeted either appetite suppression or increased metabolic rate. Brown adipose tissue (BAT) possesses the capacity to expend energy in a futile cycle, thus increasing basal metabolic rate. In animal models, oestrogen has been implicated in the regulation of body weight, and it is hypothesized that oestrogen is acting by modulating BAT metabolism. A systematic search was performed, to identify research articles implementing in vivo oestrogen-related interventions and reporting outcome measures that provide direct or indirect measures of BAT metabolism. Meta-analyses were conducted where sufficient data were available. The final library of 67 articles were predominantly in rodent models and provided mostly indirect measures of BAT metabolism. Results of this review found that oestrogen's effects on body weight, in rats and possibly mice, are likely facilitated by both metabolic and appetitive mechanisms but are largely only found in ovariectomized models. There is a need for further studies to clarify the potential effects of oestrogen on BAT metabolism in gonad-intact and castrated male animal models.
Protocol for a feasibility exploratory multicentre study of factors influencing trauma patients’ outcomes of traffic crashes in Saudi Arabia
Creators: name: Rayan Jafnan M Alharbi
name: Charne Miller
name: Lewis, Virginia
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2019 Author(s). Introduction: Road traffic injury is a leading cause of death for people of all ages. The burden of road traffic injuries is well established in developed countries. However, there has been limited investigation of the incidence and burden of road traffic injury in low/middle-income countries. With a proportionally high number of road users, there is a need to explore the factors in prehospital and hospital care in Saudi Arabia (SA) that are associated with mortality for adult trauma patients following road traffic crashes (RTCs). This paper outlines the method for the planned research. Methods and analysis: A feasibility exploratory multicentre study will be conducted at three purposefully selected hospitals with different trauma care resources in differing geographic locations of SA. The study sample will include all adult trauma patients who are involved in RTCs in SA and have been admitted to a study site in a 3-month period from May to July 2019. Data regarding the characteristics of the crashes and prehospital health care factors will be extracted from hospital databases where it is available. Information will be collected from patients or carers and hospital records in the two sites that do not have a registry. Patient status at 30 days post-injury, particularly mortality, will be assessed through hospital records. The relative contribution of a range of factors to predicting mortality will be explored using logistic regression analysis. Ethics and dissemination: This study was approved by the Institutional Review Board Committee at King Saud Medical City (H-01-R-053), the General Department of Research and Studies at the Ministry of Health in SA (1440-1249939) and (1440-1398648), and the La Trobe University Human Research Ethics Committee (HEC19095). The results will be reported in a thesis and in peer-reviewed journal articles and conference presentations.
Additional file 4 of Exploring hub pyroptosis-related genes, molecular subtypes, and potential drugs in ankylosing spondylitis by comprehensive bioinformatics analysis and molecular docking
Creators: name: Li, Xin
name: Li, Xiangying
name: Wang, Hongqiang
name: Zhao, Xiang
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 4: Supplementary file 5. Detection of outliers and rejection.
sj-pdf-4-eex-10.1177_2515127420969957 - Supplemental material for Developing Educational Escape Rooms for Experiential Entrepreneurship Education
Creators: name: Martina, Richard A.
name: Göksen, Sultan
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business

description: Supplemental material, sj-pdf-5-eex-10.1177_2515127420969957 for Developing Educational Escape Rooms for Experiential Entrepreneurship Education by Richard A. Martina and Sultan Göksen in Entrepreneurship Education and Pedagogy
Safety and immunogenicity of a third-dose homologous BBIBP-CorV boosting vaccination: interim results from a prospective open-label study
Creators: name: Ai, Jingwen
name: Zhang, Yi
name: Zhang, Haocheng
name: Zhang, Qiran
name: Fu, Zhangfan
name: Lin, Ke
name: Song, Jieyu
name: Zhao, Yuanhan
name: Fan, Mingxiang
name: Wang, Hongyu
name: Zhou, Yang
name: Chen, Xiaohua
name: Qiu, Chao
name: Zhang, Wenhong
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: COVID-19 booster vaccination is being comprehensively evaluated globally due to the emerging concern of reduced protection rate of previous vaccination and circulating Variants of Concern (VOC). But the safety and immunogenicity of homologous BBIBP-CorV boosting vaccination is yet to be thoroughly evaluated. We conducted this prospective, open-label study in Huashan Hospital using a third 6.5U BBIBP-CorV administered at an interval of 4 to 8 months following previous two doses in healthy adults. Safety, anti-RBD response and neutralizing titers against SARS-CoV-2 and VOCs were examined. Sixty-three and forty participants entered booster and control group respectively. A significant increase in IFN-γ SFU per million PBMCs was observed on day 14 against N peptide (20 vs 5, P＜0.001). At day 14, pVNT GMTs increased over 15 folds of the baseline levels against prototype to reach 404.54 titer and over 9-13 folds against 4 VOCs, and continuously increased by day 28. sVNT GMTs increased 112.51 and 127.45 folds by day 14 and 28 compared to baseline level. Median anti-RBD antibody and IgG level significantly increased from 11.12 BAU/ml to 2607.50 BAU/ml and 4.07 BAU/ml to 619.20 BAU/ml on day 14. At Day 14, female showed a significantly higher cell-mediated immune response against S1 peptide, and 7-8 months interval group had a higher humoral response than 4-6 months interval group. No severe adverse event was reported. A third homologous BBIBP-CorV boosting vaccination was safe and highly immunogenic for healthy adults, as well as broadened participant’s immunity against VOCs. Trial registration:ClinicalTrials.gov identifier: NCT05095298.
Online_appendix-RR2 – Supplemental material for Unintended Short- and Longer-Term Consequences of Assignment to College Readiness Courses: Evidence from Florida
Creators: name: Leeds, Daniel M.
name: Mokher, Christine G.
Publisher: name: SAGE Journals
Year: 2020
Subjects: Education

description: Supplemental material, Online_appendix-RR2 for Unintended Short- and Longer-Term Consequences of Assignment to College Readiness Courses: Evidence from Florida by Daniel M. Leeds and Christine G. Mokher in Educational Policy
The decline in youth drinking in England – is everyone drinking less? A quantile regression analysis.
Creators: name: Oldham, Melissa
name: Callinan, Sarah
name: Whitaker, Victoria
name: Fairbrother, Hannah
name: Curtis, Penny
name: Meier, Petra
name: Livingston, Michael
name: Holmes, John
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2019 The Authors. Addiction published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction Background and Aims: Youth alcohol consumption has declined significantly during the past 15 years in many high-income countries, which may have significant public health benefits. However, if the reductions in drinking occur mainly among lighter drinkers who are at lower risk, then rates of alcohol-related harm among young people today and adults in future may not fall in line with consumption. There is conflicting evidence from Swedish school studies, with some suggesting that all young people are drinking less, while others suggest that alcohol consumption among heavier drinkers may be stable or rising while average consumption declines. This paper extends the geographical focus of previous research and examines whether the decline in youth drinking is consistent across the consumption distribution in England. Design: Quantile regression of 15 waves of repeat cross-sectional survey data. Setting: England, 2001–16. Participants: A total of 31 882 schoolchildren (50.7% male) aged 11–15 who responded to the Smoking Drinking and Drug Use among Young People surveys. Measurements: Past-week alcohol consumption in UK units at each fifth percentile of the consumption distribution. Findings: Reductions in alcohol consumption occurred at all percentiles of the consumption distribution analysed between 2001 and 2016, but the magnitude of the decline differed across percentiles. The decline in consumption at the 90th percentile [β = −0.21, confidence interval (CI) = −0.24, −0.18] was significantly larger than among either lighter drinkers at the 50th percentile (β = −0.02, CI = −0.02, −0.01) or heavier drinkers at the 95th percentile (β = −0.16, CI = −0.18, −0.13). Conclusions: Alcohol consumption among young people in England appears to be declining across the consumption distribution, and peaks among heavy drinkers. The magnitude of this decline differs significantly between percentiles of the consumption distribution, with consumption falling proportionally less among the lightest, moderate and very heaviest youth drinkers.
sj-pdf-1-vas-10.1177_1708538120957478 - Supplemental material for Primary leiomyosarcoma is a rare cause of femoral triangle mass: A case report
Creators: name: Yingjiang Xu
name: Weiping Xie
name: Shang, Dan
Publisher: name: SAGE Journals
Year: 2020
Subjects: Cardiology

description: Supplemental material, sj-pdf-1-vas-10.1177_1708538120957478 for Primary leiomyosarcoma is a rare cause of femoral triangle mass: A case report by Yingjiang Xu, Weiping Xie and Dan Shang in Vascular
Social media, body image and food choices in healthy young adults: A mixed methods systematic review
Creators: name: Rounsefell, Kim
name: Gibson, Simone
name: McLean, Sian
name: Merran Blair
name: Molenaar, Annika
name: Brennan, Linda
name: Truby, Helen
name: McCaffrey, Tracy A
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2019 Dietitians Association of Australia Aim: Negative body image increases the risk of engaging in unhealthy dieting and disordered eating patterns. This review evaluated the impact of habitual social media engagement or exposure to image-related content on body image and food choices in healthy young adults (18-30 years). Methods: A systematic search of six databases of observational literature published 2005-2019, was conducted (PROSPERO Registration No. CRD42016036588). Inclusion criteria were: studies reporting social media engagement (posting, liking, commenting) or exposure to image-related content in healthy young adults. Outcomes were: body image (satisfaction or dissatisfaction) and food choices (healthy eating, dieting/restricting, overeating/binging). Two authors independently screened, coded and evaluated studies for methodological quality. Results: Thirty studies were identified (n = 11 125 participants). Quantitative analysis (n = 26) identified social media engagement or exposure to image-related content was associated with higher body dissatisfaction, dieting/restricting food, overeating, and choosing healthy foods. Qualitative analysis (n = 4) identified five themes: (i) social media encourages comparison between users, (ii) comparisons heighten feelings about the body, (iii) young adults modify their appearance to portray a perceived ideal image, (iv) young adults are aware of social media's impact on body image and food choices, however, (v) external validation via social media is pursued. Most studies (n = 17) controlled for some confounding variables (age, gender, BMI, ethnicity). Conclusions: Social media engagement or exposure to image-related content may negatively impact body image and food choice in some healthy young adults. Health professionals designing social media campaigns for young adults should consider image-related content, to not heighten body dissatisfaction.
Georeferencing and Mapping Fossil Vertebrate Localities into the Bureau of Land Management's Colorado Statewide Locality Database
Creators: name: Van Veldhuizen, Jacob
Publisher: name: Zenodo
Year: 2022

description: Abstract of conference poster on Georeferencing and Mapping Fossil Vertebrate Localities into the Bureau of Land Management's Colorado Statewide Locality Database by Vertebrate Paleontology Collections Manager Jacob Van Veldhuizen of Vertebrate Paleontology Collections Manager University of Colorado Museum of Natural History Boulder United States for SPNHC2022 Conference, Edinburgh. June 5-10th 2022.
Identification of methicillin-resistant Staphylococcus aureus ST8 isolates in China with potential high virulence
Creators: name: Wang, Xinyi
name: Zhao, Huilin
name: Wang, Bingjie
name: Zhou, Ying
name: Xu, Yanlei
name: Rao, Lulin
name: Ai, Wenxiu
name: Guo, Yinjuan
name: Wu, Xiaocui
name: Yu, Jingyi
name: Hu, Longhua
name: Han, Lizhong
name: Chen, Shuying
name: Chen, Liang
name: Yu, Fangyou
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Methicillin-resistant Staphylococcus aureus (MRSA) ST8 strains have spread worldwide, causing outbreaks in various regions. However, this clone has only been sporadically reported in China. Consequently, detailed information regarding the phylogeny and potential virulence of S. aureus ST8 strains in China remains unknown. In this study, we characterized six ST8 strains collected from three tertiary hospitals in China, including three MRSA (MR50, MR526, and MR254) and three MSSA (H78, H849 and H863). Whole genome sequencing and phylogenetic analysis showed that the six strains formed two separate clusters, including two (MR50 and MR526) and four (MR254, H78, H849 and H863) isolates, respectively. Among them, MR50 and MR526 harboured spa t008, SCCmec IVa, arginine catabolic mobile element, and were phylogenetically close to the epidemic USA300 strains, while other four strains belonged to spa t9101 and formed a unique branch. MR254 carried a novel hybrid SCCmec element (namely SCCmec254). Same as the USA300 prototype strain LAC, the China S. aureus ST8 strains produced weak biofilms except MR254. Among them, MR254 had significantly stronger haemolysis ability and higher α-toxin levels than others, while MR526 showed comparable haemolysis and α-toxin production levels as USA300-LAC. In mouse skin abscess model, MR254 showed particularly strong invasions, accompanied by necrosis, while MR526 exhibited similar infection levels as USA300-LAC. These data suggested that the China MRSA ST8 isolates (e.g. MR254 and MR526) were highly virulent, displaying higher or similar virulence potential as the epidemic USA300 strain. Active surveillance should be enacted to closely monitor the further spread of these hyper-virulent MRSA strains in China.
Supplementary_materials – Supplemental material for Linoleic acid-modified liposomes for the removal of protein-bound toxins: An in vitro study
Creators: name: Shen, Yue
name: Shen, Yuqi
name: Bi, Xiao
name: Li, Jiaolun
name: Chen, Yingjie
name: Zhu, Qiuyu
name: Wang, Yifeng
name: Ding, Feng
Publisher: name: SAGE Journals
Year: 2020
Subjects: Biological Sciences not elsewhere classified

description: Supplemental material, Supplementary_materials for Linoleic acid-modified liposomes for the removal of protein-bound toxins: An in vitro study by Yue Shen, Yuqi Shen, Xiao Bi, Jiaolun Li, Yingjie Chen, Qiuyu Zhu, Yifeng Wang and Feng Ding in The International Journal of Artificial Organs
"But It's Honoring! It's Tradition!": The Persistence of Racialized Indian Mascots in Sports
Creators: name: Williams, Dana
Publisher: name: Sage
Year: 2021
Subjects: subject: Sports team mascots
subject: Indians as mascots
subject: College sports
subject: Indians of North America
subject: Indigenous peoples
subject: Culture
subject: Sports--Sociological aspects

description: Native American mascots and team names are remarkably common in the United States. Whereas there are only a handful of White ethnic team names, hundreds of high school, college, and professional teams reference Native Americans. This phenomenon is also unique because these teams are not typically owned by Native Americans, nor are they composed of Native American athletes, nor are the teams or schools usually located in areas with large Native American populations (with only a few exceptions). The most common nicknames include Braves, Chiefs, Indians (by far the most popular), Redmen, Savages, and Warriors, as well as numerous specific nations, such as Apaches, Hurons, Mohawks, and Seminoles. For most of the history of this practice, few non–Native Americans have complained about these team names. However, sports are not as apolitical as people typically assume. They are often a battleground for struggles over important societal symbols, including those related to race.
Sequential infections with rhinovirus and influenza modulate the replicative capacity of SARS-CoV-2 in the upper respiratory tract
Creators: name: Essaidi-Laziosi, Manel
name: Alvarez, Catia
name: Puhach, Olha
name: Sattonnet-Roche, Pascale
name: Torriani, Giulia
name: Tapparel, Caroline
name: Kaiser, Laurent
name: Eckerle, Isabella
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Although frequently reported since the beginning of the pandemic, questions remain regarding the impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) interaction with circulating respiratory viruses in coinfected patients. We here investigated dual infections involving early-pandemic SARS-CoV-2 and the Alpha variant and three of the most prevalent respiratory viruses, rhinovirus (RV) and Influenza A and B viruses (IAV and IBV), in reconstituted respiratory airway epithelial cells cultured at air–liquid interface. We found that SARS-CoV-2 replication was impaired by primary, but not secondary, rhino- and influenza virus infection. In contrast, SARS-CoV-2 had no effect on the replication of these seasonal respiratory viruses. Inhibition of SARS-CoV-2 correlated better with immune response triggered by RV, IAV and IBV than the virus entry. Using neutralizing antibody against type I and III interferons, SARS-CoV-2 blockade in dual infections could be partly prevented. Altogether, these data suggested that SARS-CoV-2 interaction with seasonal respiratory viruses would be modulated by interferon induction and could impact SARS-CoV-2 epidemiology when circulation of other respiratory viruses is restored.
¹³C-DNA-SIP distinguishes the prokaryotic community that metabolizes soybean residues produced under different CO₂ concentrations
Creators: name: Wang, Yanhong
name: Yu, Zhenhua
name: Li, Yansheng
name: Wang, Guanghua
name: Tang, Caixian
name: Liu, Xiaobing
name: Liu, Junjie
name: Xie, Zhihuang
name: Jin, Jian
Publisher: name: La Trobe
Year: 2021
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3103
subject: Ecology
classificationCode: 3107
subject: Microbiology
classificationCode: 3207
subject: Medical microbiology

description: © 2019 Wang, Yu, Li, Wang, Tang, Liu, Liu, Xie and Jin. The amendment of crop residues produced under elevated CO2 (eCO2) may alter soil microbial community structure and their functions on residue decomposition and carbon (C) cycling in soil. The key to understanding this process is to elucidate the structure of prokaryotic communities that metabolize crop residues derived from eCO2. A soil incubation experiment was conducted to explore the response of soil microbial community to the amendment of13 C-labeled soybean residues produced under ambient CO2 (aCO2) and eCO2. The residues were applied to a Mollisol, followed by13 C-DNA stable isotope probing (SIP) and Illumina sequencing on soil prokaryotic community over time. The structure of residue-metabolizing community differed in response to the amendment of eCO2-and aCO2-derived residues after 28 days of incubation. In particular, genera Actinomadura, Nocardia, Non-omuraea, and Shimazuella were the dominant members of the residue-metabolizing bacteria, which contributed to this difference. The relative abundances of genera Actinomadura, Nocardia and Shimazuella were 118–144%, 71–113%, and 2–4-fold higher in the Mollisol amended with aCO2-derived than eCO2-derived residue. In contrast, the relative abundance of Non-omuraea was 87–90% greater in the eCO2-residue treatment. However, during the incubation period, there was no difference between the two residue treatments in the community structure as a whole without SIP. These results implied that a pioneering prokaryotic community metabolized the residue initially prior to the entire community. Those bacteria genera being inhibited with the amendment of the eCO2-derived residue, compared to aCO2-derived residue, were likely preferential to metabolize recalcitrant C, which might be associated with changes of chemical composition of the residue under eCO2.
Spectrophotometric determination of mesalamine using sodium nitroprusside as chromogenic reagent
Creators: name: Al-Sabha, Theia'a N.
name: Habeeb, Nagham N.
Publisher: name: European Chemical Bulletin
Year: 2015

description: A simple, sensitive and accurate spectrophotometric method has been developed for the determination of mesalamine in pure form and commercial dosage form. The method is based on the reaction of mesalamine with sodium nitroprusside in the presence of hydroxylamine hydrochloride in alkaline medium to give a highly green colored species which absorb maximally at 703 nm. Beer's law is obeyed in the concentration ranges 0.0-30 µg mL-1 with molar absorptivity 2.0367´104 L.mol-1cm-1. The average recovery is 103.0 % and relative standard deviation is less than 1.5 % (n=6). The proposed method was applied successfully for determination of mesalamine in commercial pharmaceuticals as tablet and suppositories. There is no interference from the excipients.
description: European Chemical Bulletin, Vol 4, No 7-9 (2015): European Chemical Bulletin
Identification of methicillin-resistant Staphylococcus aureus ST8 isolates in China with potential high virulence
Creators: name: Wang, Xinyi
name: Zhao, Huilin
name: Wang, Bingjie
name: Zhou, Ying
name: Xu, Yanlei
name: Rao, Lulin
name: Ai, Wenxiu
name: Guo, Yinjuan
name: Wu, Xiaocui
name: Yu, Jingyi
name: Hu, Longhua
name: Han, Lizhong
name: Chen, Shuying
name: Chen, Liang
name: Yu, Fangyou
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Methicillin-resistant Staphylococcus aureus (MRSA) ST8 strains have spread worldwide, causing outbreaks in various regions. However, this clone has only been sporadically reported in China. Consequently, detailed information regarding the phylogeny and potential virulence of S. aureus ST8 strains in China remains unknown. In this study, we characterized six ST8 strains collected from three tertiary hospitals in China, including 3 MRSA (MR50, MR526 and MR254) and 3 MSSA (H78, H849 and H863). Whole genome sequencing and phylogenetic analysis showed that the six strains formed two separate clusters, including 2 (MR50 and MR526) and 4 (MR254, H78, H849 and H863) isolates, respectively. Among them, MR50 and MR526 harbored spa t008, SCCmec IVa, ACME, and were phylogenetically closed to the epidemic USA300 strains, while other four strains belonged to spa t9101 and formed a unique branch. MR254 carried a novel hybrid SCCmec element (namely SCCmec254). Same as the USA300 prototype strain LAC, the China S. aureus ST8 strains produced weak biofilms except MR254. Among them, MR254 had significantly stronger hemolysis ability and higher α-toxin levels than others, while MR526 showed comparable hemolysis and α-toxin production levels as USA300-LAC. In mouse skin abscess model, MR254 showed particularly strong invasions, accompanied by necrosis, while MR526 exhibited similar infection levels as USA300-LAC. These data suggested that the China MRSA ST8 isolates (e.g. MR254 and MR526) were highly virulent, displaying higher or similar virulence potential as the epidemic USA300 strain. Active surveillance should be enacted to closely monitor the further spread of these hyper-virulent MRSA strains in China.
Emergence of colistin-resistant hypervirulent Klebsiella pneumoniae (CoR-HvKp) in China
Creators: name: Liu, Xiaoyu
name: Wu, Yarong
name: Zhu, Ying
name: Jia, Peiyao
name: Li, Xue
name: Jia, Xinmiao
name: Yu, Wei
name: Cui, Yujun
name: Yang, Ruifu
name: Xia, Wei
name: Xu, Yingchun
name: Yang, Qiwen
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Colistin is regarded as a last-resort agent to combat infections caused by multidrug-resistant (MDR) Gram-negative bacteria, especially carbapenem-resistant isolates. In recent years, reports of colistin-resistant Klebsiella pneumoniae (CoRKp) are increasing. However, the molecular mechanism and relevance of colistin resistance and virulence remain unclear. Fourteen CoRKp strains were retrospectively screened from 1,884 clinical K. pneumoniae isolates during 2017-2018 in China. Six CoRKp strains belonging to ST11 were MDR strains. Plasmid-mediated mobile colistin resistance genes had a low prevalence in CoRKp. Our results revealed that upregulated expression of two-component systems, especially phoPQ, contributed more to colistin resistance. mgrB mutation was the most common molecular mechanism of colistinresistance , caused by either nonsense mutations or insertion sequences, which drove the overexpression of phoPQ system. This study also identified three novel point mutations in pmrAB system, in which D313N mutation in pmrB was proved to increase the MIC to colistin by 16-fold. In addition, 6 out of 14 CoRKP strains independentlycarried hypervirulence genes. All 6 strains showed medium-to-high virulence phenotype compared with NTUH-K2044 strain in mice intraperitoneal challenge models. We found that 4 strains were biofilm strong producers and transcriptome analysis revealed that 3 of them significantly upregulated expression of type Ⅲ fimbrial shaft gene mrkA. In conclusion, our result revealed the emergence of colistin-resistant and hypervirulent MDR K. pneumoniae, which is a noticeable superbug and could cause a severe challenge to public health.
Additional file 1 of Do outcomes for patients with hospital-acquired Acute Kidney Injury (H-AKI) vary across specialties in England?
Creators: name: Magadi, Winnie
name: Peracha, Javeria
name: McKane, William S
name: Savino, Manuela
name: Braddon, Fiona
name: Steenkamp, Retha
name: Nitsch, Dorothea
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Cell Biology
Biotechnology
Biological Sciences not elsewhere classified
Computational Biology

description: Supplementary Material 1
Supplementary_materials – Supplemental material for Prevalence of Diabetes Mellitus and Its Associated Unfavorable Outcomes in Patients With Acute Respiratory Syndromes Due to Coronaviruses Infection: A Systematic Review and Meta-Analysis
Creators: name: Pinedo-Torres, Isabel
name: Flores-Fernández, Magaly
name: Yovera-Aldana, Marlon
name: Gutierrez-Ortiz, Claudia
name: Zegarra-Lizana, Paolo
name: Intimayta-Escalante, Claudio
name: Moran-Mariños, Cristian
name: Alva-Diaz, Carlos
name: Pacheco-Barrios, Kevin
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 110306 Endocrinology
subject: FOS: Clinical medicine

description: Supplemental material, Supplementary_materials for Prevalence of Diabetes Mellitus and Its Associated Unfavorable Outcomes in Patients With Acute Respiratory Syndromes Due to Coronaviruses Infection: A Systematic Review and Meta-Analysis by Isabel Pinedo-Torres, Magaly Flores-Fernández, Marlon Yovera-Aldana, Claudia Gutierrez-Ortiz, Paolo Zegarra-Lizana, Claudio Intimayta-Escalante, Cristian Moran-Mariños, Carlos Alva-Diaz and Kevin Pacheco-Barrios in Clinical Medicine Insights: Endocrinology and Diabetes