Pregnancy outcomes in women with polycystic ovary syndrome in two Latin American populations
Creators: name: Fux-Otta, Carolina
name: Maliqueo, Manuel
name: Echiburú, Bárbara
name: Rosato, Otilio
name: Crisosto, Nicolás
name: Iraci, Gabriel S.
name: Cuneo, Marta Fiol De
name: Mereshian, Paula Szafryk De
name: Sir-Petermann, Teresa
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: FOS: Mathematics
subject: Cancer

description: Pregnancy complications and obstetric outcomes were compared in 80 Chilean (PPCOS<sub>Ch</sub>) and 70 Argentinian (PPCOS<sub>Ar</sub>) pregnant women. Reference groups of Chilean and Argentinian normal pregnant women from the same antenatal care units were also compared. PPCOS<sub>Ch</sub> showed a higher prevalence of gestational diabetes mellitus (GDM) (OR, 2.28, 95% CI: 1.08–4.77, <i>p</i> = .030) and a lower prevalence of pregnancy-induced hypertension (PIH) (OR, 0.20, 95% CI: 0.07–0.54, <i>p</i> = .001) compared to PPCOS<sub>Ar</sub>. In the normal pregnant groups, the prevalence of PIH was lower in Chilean women compared to Argentinian women (OR, 0.24, 95% CI: 0.10–0.62, <i>p</i> = .001). Similar to the pattern observed in the normal populations, newborns from PPCOS<sub>Ch</sub> had higher birth weight and length compared with the newborns of PPCOS<sub>Ar</sub> (<i>p</i> = .006 and .014, respectively). In conclusion, differences in pregnancy complications and obstetric outcomes between Chilean and Argentinian pregnant women with PCOS could be determined by ethnic diversity together with environmental factors of both populations.Impact Statement<b>What is already known on this subject:</b> The reproductive and metabolic phenotypes of women with polycystic ovary syndrome vary between different populations, which could significantly influence the obstetric and neonatal outcomes in this syndrome.<b>What the results of this study add:</b> Pregnant women with PCOS from two Latin American countries (Chile and Argentina) exhibit differences in the prevalence of gestational diabetes and pregnancy-induced hypertension, and in the birth weight of their newborns.<b>What the implications are of these findings for clinical practice and/or further research:</b> Ethnic diversity together with environmental factors are fundamental elements that must be considered in the management of pregnant women with PCOS. <b>What is already known on this subject:</b> The reproductive and metabolic phenotypes of women with polycystic ovary syndrome vary between different populations, which could significantly influence the obstetric and neonatal outcomes in this syndrome. <b>What the results of this study add:</b> Pregnant women with PCOS from two Latin American countries (Chile and Argentina) exhibit differences in the prevalence of gestational diabetes and pregnancy-induced hypertension, and in the birth weight of their newborns. <b>What the implications are of these findings for clinical practice and/or further research:</b> Ethnic diversity together with environmental factors are fundamental elements that must be considered in the management of pregnant women with PCOS.