cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Darstellung und Charakterisierung neuartiger Sonden zur Bestimmung der Aktivität pathologisch relevanter Proteasen
Creators: name: Blume, Berit
Publisher: name: Hannover : Institutionelles Repositorium der Leibniz Universität Hannover
Year: 2023
Subjects: subject: Fluoreszenz
subject: FRET
subject: Imaging
subject: Kontrastmittel
subject: Krebs
subject: Protease
subject: Radioaktivität
subject: Dewey Decimal Classification::500 | Naturwissenschaften::540 | Chemie

description: Die Differenzierung zwischen gesundem Gewebe und Tumor ist intraoperativ nur unzureichend durch optische Unterscheidung und Abtasten des Gewebes möglich, dabei wird die Prognose des Patienten direkt durch das Resektionsausmaß bestimmt. Deshalb werden Methoden benötigt, durch die der Chirurg den Tumor präzise erkennen und von gesundem Gewebe differenzieren kann. Der Einsatz fluoreszenter Kontrastmittel in der intraoperativen Bildgebung kann diese Hürde überwinden. Um ein hohes Signal-Hintergrund Verhältnis zu erreichen, eignen sich vor allem zielgerichtete Kontrastmittel. Dabei rücken die Protease-aktivierbaren Sonden immer weiter in den Fokus. Trotz umfangreicher Charakterisierungen dieser Sonden sind die Spaltungs- und Aufnahmemechanismen der Verbindungen nicht vollständig geklärt und bedürfen weiterer Arbeiten. Im ersten Teil dieser Dissertation wurden neuartige Sonden, basierend auf einem interessanten publizierten System, synthetisiert und diese auf ihre optischen und biologischen Eigenschaften charakterisiert. Ein Vergleich der in vitro und in vivo Ergebnisse zu dem vor FDA-Zulassung stehenden LUM015 ermöglichte eine Einschätzung der Daten in Bezug auf eine mögliche klinische Anwendung. Fluoreszente Kontrastmittel eignen sich auf Grund der geringen Eindringtiefe nur für intraoperative Zwecke, weshalb in einem zweiten Teil dieser Arbeit multimodale Sonden für die Anwendung in der Diagnostik synthetisiert wurden. Dabei lag der Fokus auf nuklearmedizinischen Methoden, für den Einsatz in der Positronen-Emissions-Tomographie (PET) oder der Einzelphotonen-Emissionscomputertomographie (SPECT). Im letzten Teil der Arbeit wurde in einem weiteren Fluoreszenz-basierten Ansatz ein Konzept für photokonvertierbare Sonden entwickelt. Diese Klasse an Sonden ermöglichen es Zellmigrationen nachzuverfolgen und dadurch einen besseren Einblick in biologische Prozesse während pathologischer Veränderungen zu erhalten. In den letzten Jahren wurden bereits einige Beispiele für eine in vitro Anwendung von verschiedenen Gruppen publiziert, die auf Transfektion und Entwicklung transgener Mausmodelle beruhen. In diesem Teil der Dissertation ist die Synthese, sowie die Charakterisierung der optischen und biologischen Eigenschaften neuer photokonvertierbarer Sonden, die keine genetische Manipulation benötigen, beschrieben.
Additional file 7: Figure S4. of Transcriptional analysis of sweet orange trees co-infected with ‘Candidatus Liberibacter asiaticus’ and mild or severe strains of Citrus tristeza virus
Creators: name: Shimin Fu
name: Shao, Jonathan
name: Paul, Cristina
name: Changyong Zhou
name: Hartung, John
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology
subject: Computational Biology

description: Effects on tetrapyrrole biosynthetic pathway by co-infection with CTV-B2/CaLas-B232 and CTV-B6/CaLas-B232. (PDF 124 kb)
An analysis of the efficacy of the Advancement Via Individual Determination (AVID) intervention program
Creators: name: Bleakley, David A.
Publisher: name: No Publisher Supplied
Year: 2013

description: PROBLEM: This study investigated the effectiveness of the Advancement Via Individual Determination (AVID) at Fairview High School.  AVID’s mission is to close the achievement gap by preparing students for college readiness.  The achievement gap is a phenomenon observed generally across American schools, and specifically at Fairview High School.  The study answered the research question:  What effect does participation in AVID at Fairview High School have on selected student performance indicators after at least one year of enrollment in the AVID elective class?    METHOD: The study used a quasi-experimental design with a sample of 6& students who experienced AVID for at least one academic year and 69 students who did not.  When comparing the two groups analyses controlled for student grade point averages prior to entry into the AVID program, prior standardized test performance, ethnicity, gender, and free or reduced lunch status.  Regression analysis was used to estimate AVID’s impact on indicators of college readiness including the strength of student schedules, student grade point average (GPA), standardized test performance in Math and Language Arts, PSAT participation, PSAT scores, and attendance.    FINDINGS: AVID’s estimated impact was statistically significant on 4 of 13 outcome measures.  There was a statistically significant direct relationship between participation in AVID and the strength of a student’s schedule, student performance on the grade 11 Language Arts section of the HSPA, and participation in the PSAT.  There was a statistically significant inverse relationship between participation in AVID and GPA.    SIGNIFICANCE:  The significance of the study is that it provides information to the Fairview High School site team on the extent to which the investment in the AVID program is producing its intended effects.  The findings imply that certain aspects of AVID’s implementation are contributing to positive measured effects.  However, the findings also demonstrate one negative effect and multiple outcomes without any measurable effect.  The site team at Fairview High School will be able to use the results of this study to assess AVID’s impact as well as to determine areas of future study regarding AVID’s implementation and effects at Fairview High School.
Exploring and justifying ideas in an undergraduate mathematics course
Creators: name: Brophy, Anna
Publisher: name: No Publisher Supplied
Year: 2013

description: The improvement of mathematics education relies very heavily on the improvement of undergraduate mathematics education for future teachers (National Research Council, 1989). It is important that undergraduate mathematics instruction for prospective teachers demonstrates techniques to be used in their future classrooms (Blair, 2006; Senk, Keller, & Ferrini-Mundy, 2004). Specifically, pre-service teachers should develop an understanding of the mathematical processes of exploration and proof (Senk, Keller, & Ferrini-Mundy, 2004).  If problems that encourage mathematical exploration and justification are to be brought into the undergraduate classroom, understanding how students build and justify their solutions will be of importance. The purpose of this research was to (1) investigate how undergraduate students enrolled in a mathematics course solve and justify their solution to a series of combinatorics tasks, (2) analyze the moves employed by the instructor and (3) investigate how their solutions compare to the solutions of other students involved in the same problem-solving tasks.  This case study was conducted in a mathematics class at a liberal arts college. The six students in this class were all mathematics majors studying to be teachers. Using videotaped data and students’ written work, a careful analysis of how the students built their solutions and justified their answers to three combinatoric problems was conducted.   It was found that the strategies and justifications used by the students in this study were similar to those used by participants in earlier studies. Furthermore, in investigating how the college math students built their solutions to the problems, it was found that the instructor played a critical role in the learning process.  Findings from this study verify that mathematical learning can take place in a college mathematics class that fosters mathematical exploration and justification with well-chosen tasks, collaboration with peers, and student-centered instruction. This study also has implications for implementation in other settings by providing examples of students’ solutions to specific tasks as well as examples of how instructors can effectively interact with students in a mathematical classroom that nurtures the mathematical processes of conjecturing, generalizing, and justifying solutions to problems.
Teleiopsis laetitiae Schmid 2011
Creators: name: Bryner, Rudolf
name: Kopp, Andreas
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Gelechiidae
Teleiopsis
Teleiopsis laetitiae

description: 3451a Teleiopsis laetitiae Schmid, 2011 – GR
Schmid (2011a): Nota Lepidopterologica 33: 273.
3471a Gelechia obscuripennis (Frey, 1880) – WA
Diese früher als SYnonYm von Gelechia senticetella (Staudinger, 1859) betrachtete Art ist belegt aus Leuk (VS), Brentschen, 1650 m ü. M., 28.6.2016 (leg. D. Robrecht, det. P. Huemer) Huemer (2020a): Lepiforum.
description: Published as part of Bryner, Rudolf & Kopp, Andreas, 2023, Aktualisierung der Checkliste der Schmetterlinge (Lepidoptera) der Schweiz, pp. 39-60 in Entomo Helvetica 16 on page 49
Using game-based learning to foster critical thinking in student discourse
Creators: name: Cicchino, Marc I.
Publisher: name: No Publisher Supplied
Year: 2013

description: In spite of a global shift that emphasizes the importance of critical thinking skills,  America’s schools are not yet equipped with a sufficient repertoire of pedagogical strategies necessary to foster these skills. The purpose of this dissertation is to explore the effectiveness of game-based learning (GBL) as a strategy for fostering higher-level critical-thinking skills so that it may potentially be appropriated for popular use in traditional school environments. I examined student discourse throughout a GBL intervention designed to promote content knowledge and critical thinking in an eighth grade social studies classroom. A total of three 8th grade social studies classes engaged in the intervention. Post-tests and delayed post-tests were conducted for the entire 8th grade (ten social studies classes across two instructors). Five groups of students that engaged in the GBL intervention were videotaped and analyzed. Data analysis showed that features of the GBL intervention and particular cycles of gameplay were effective in promoting higher levels of critical thinking, including the development of independent beliefs prior to engaging in collaborative discourse and providing opportunities for guided reflection. The portfolio that follows seeks to make the findings of my research on GBL practical via three major components: (1) an article written for publication in a scholarly journal; (2) curriculum for a fifteen-hour professional development course designed to share my learnings with fellow practitioners; and (3) a presentation to be delivered to school administrators with the purpose of sharing my findings, fostering discussion, and exploring potential avenues for effecting change in schools.
Tobacco Free Generation Policy in the Philippines: An Endgame Strategy
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Background: As a global leader in enacting innovative tobacco control policies, California is now engaged in planning for a tobacco endgame. The “Tobacco-free Generation” (TFG) idea, in which tobacco sales to those born after a specified year are banned, has been proposed in the literature as an endgame policy option. Despite a challenging public health policy environment and industry opposition, policy makers in Balanga City, Bataan Province, Philippines have passed the world’s first TFG ordinance. While the tobacco industry is continuing to challenge the ordinance in court, lessons learned from the first passage and enactment of this policy could be useful for California communities and local governments considering endgame policy measures. Lessons from Balanga City may be particularly relevant for local communities such as San Francisco and other cities where advanced and innovative tobacco control policy measures have already been achieved.

 Methods: This case study will examine 1) tobacco control advocates and policy makers’ experiences championing TFG policy and 2) tobacco industry activities aimed at weakening TFG. Semi-structured interviews (n=20) and focus groups (n=2-3) will be conducted in English with tobacco control policy advocates, policy makers and others involved in TFG policy. Recruitment will begin with advocates involved in TFG policy in Balanga City and then extend to peer referrals. Analysis of relevant media accounts and publicly available legal and tobacco industry documents will also be incorporated to contextualize the data obtained from participant interviews and focus groups.

 The case study will be guided by Schneider & Ingram’s Social Construction of Target Populations Theory, which theorizes how views of different social groups determine interaction in and with the government, which, in turn, affects the motivations, priorities, and agendas guiding policy makers.

 Analysis: A qualitative, interpretive approach will be used to code professionally transcribed audio recorded data, utilizing data management software. Analysis will focus on identifying and describing key roles, messaging and practices used in advancing and implementing TFG, pitfalls and obstacles encountered, and lessons for other communities potentially seeking to pass this or similar endgame-oriented local policy ordinances in California.
Cotycicuiara chionea Martins & Galileo 2010
Creators: name: Groll, Elisa Von
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Cotycicuiara
Cotycicuiara chionea

description: Cotycicuiara chionea Martins & Galileo, 2010
Martins & Galileo, 2010:4, fig. 5.
Paratype ♀, BRAZIL, Rio de Janeiro: Rio de Janeiro (MCNZ 237.054).
description: Published as part of Groll, Elisa Von, 2017, Catalogue of Coleoptera type specimens housed in the collection of the Museu de Ciências Naturais, Fundação Zoobotânica do Rio Grande do Sul, Brazil, pp. 439-473 in Zootaxa 4318 (3) on page 450, DOI: 10.11646/zootaxa.4318.3.2, http://zenodo.org/record/887750
Literacies and Identities of three generations of Syrian-Jewish young adult females
Creators: name: Sarfaty, Debra
Publisher: name: No Publisher Supplied
Year: 2013

description: This dissertation focused on the literacy shifts taking place over the course of three generations of Syrian-Jewish women.  Based on sociocultural theory, this research project explored the changing literacy practices of Syrian-Jewish women and how these practices impact the identities of these women, specifically in regards to being members of the Syrian-Jewish community.  This research is unique as the Syrian-Jewish community’s literacy practices are not discussed in the literature and the community is different from most studied communities as it is affluent, not marginalized, and already well versed in its native tongue, English.  Over the course of 1 year  I conducted interviews with the main participants and elites, gathered artifacts, and collected archival records from community magazines.  The data was organized by research question and coded with both word analysis and category creation.  Data was analyzed through the sociocultural lenses of Discourse and literacy practices.  The study revealed that a sociocultural theory of literacy is reflected in literacy practices in a myriad of ways.  Although other studies revealed alienation of community members because of their lack of literacy skills, this research revealed a community in which alienation of members with greater literacy skills occurred.  In addition to findings that are important to the field of sociocultural literacy, this study revealed valuable literacy information about this community in particular, and communities in general, where literacy shifts have been encounteredthat encounter literacy shifts.  Though there is a stereotypical perception that Syrian-Jewish women have limited literacy practices, my findings revealed women with rich, literate lives.  The different family groups showed specific literacy patterns and different generations also showed specific literacy patterns.  Differences in literacy practices did influence the way participants perceived themselves specifically in connection to the community.  In general, changes in literacy practices were influenced by individual, community, and economic factors and were still in flux, meaning that change did not seem to happen over the course of one generation but over many.
Desoria trispinata
Creators: name: Mayvan, Mahmood Mehrafrooz
name: Greenslade, Penelope
name: Sadeghi-Namaghi, Hussein
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Entomobryomorpha
Isotomidae
Desoria
Desoria trispinata

description: Desoria trispinata (MacGillivray, 1896)
– Isotoma trispinata MacGillivray, 1896: 51.
NK: Mehrafrooz Mayvan et al. 2022a.
Ecology and habitat in Iran: soil under oak trees.
General distribution: considered cosmopolitan (Babenko et al. 2019).
description: Published as part of Mayvan, Mahmood Mehrafrooz, Greenslade, Penelope & Sadeghi-Namaghi, Hussein, 2023, An annotated checklist of the Collembola (Hexapoda) from Iran, pp. 1-101 in Zootaxa 5275 (1) on page 46, DOI: 10.11646/zootaxa.5275.1.1, http://zenodo.org/record/7898948
N-Acetylcysteine for Smoking Cessation in Tobacco and Cannabis Co-Use: A Randomized Controlled Trial
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Tobacco and cannabis co-use is an urgent public health problem, especially in states that have legalized cannabis such as California. Co-use of tobacco and cannabis may make quitting either substance more challenging and interfere with progress in treatment. Co-use is associated with powerful cues that reinforce use and make it more difficult to withstand craving. Currently there are no FDA-approved medications that target both tobacco and cannabis use disorders.
 N-Acetylcysteine (NAC) is an FDA-approved medication that is also available over the counter as an antioxidant supplement. Animal studies and human clinical trials have recently shown that NAC may reduce craving and use of both tobacco and cannabis. NAC’s benefits in decreasing substance craving is believed to be due to its effects on the central nervous system, where it helps regulate a neurotransmitter called glutamate and reduces oxidative stress in the brain. NAC’s anti-inflammatory properties may also improve cognition, which may improve users’ ability to withstand cravings to use cannabis and tobacco. In clinical trials, NAC has been shown to reduce both cannabis and tobacco use independently. However, no clinical trials have specifically studied NAC to treat tobacco and cannabis use disorders concurrently.
 We propose a randomized controlled trial in which we will recruit 60 daily adult cigarette smokers with concurrent cannabis use disorder (CUD) and tobacco use disorder (TUD) to receive either 3600 milligrams of NAC or placebo for 8 weeks. Both groups will receive 8 sessions of behavioral coaching to support cessation of cigarettes and cannabis. Outcomes will be measured at Weeks 0, 4, 8, and 12. Primary aims are to determine the effect of NAC on daily cigarette craving, nicotine dependence levels, and use; and cannabis craving, CUD severity levels, and use. Exploratory aims include examination of changes in cognitive functioning with NAC, and the potential impact of changes in cognition on cigarette and cannabis use. To engage community stakeholders, we will assemble a panel of public health officials and clinicians with expertise in high-priority populations who co-use cannabis and tobacco, such as adolescents and pregnant women. This innovative study is responsive to the TRDRP Research Priorities of Neuroscience of Nicotine Addiction and Treatment and Behavioral Prevention and Treatment.
Smoking’s Impact on Influenza Pathogenesis and Live Attenuated Vaccine Response
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Smoking increases the risk of contracting infectious lung diseases such as Influenza virus and results in more severe symptoms and slower health recovery. Influenza A virus (Flu A) and Influenza B (Flu B) virus both cause seasonal epidemics, however no model of how smoking affects Flu B infections exists even though Flu B makes up a larger number of yearly Flu cases and deaths in specific years. Additionally, the nature of these viruses allows them to quickly adapt to vaccines requiring yearly updates. Smoking is associated with decreased vaccine effectiveness, meaning that if these viruses adapt to the vaccines quickly, smokers would be the population most adversely affected by these seasonal epidemics. Modeling how smoking affects Flu B infections and vaccine success together would increase our understanding of how the virus behaves in response to smoking and would also provide a new platform for the development of new strategies to prevent and treat infections for at risk smoking populations and the general public at large, potentially saving more lives in the event of severe epidemics. Our objective is to determine if and how cigarette smoke exposure affects Flu B disease, and to determine if smoking decreases Flu vaccine efficacy.
New mouse models for identifying driver mutations in tobacco-induced squamous cell lung cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Human squamous cell lung cancer (squamous cell carcinoma, SCC) is the second most common lung cancer and is most strongly associated with smoking in a dose-dependent manner. More than 90% of SCC was attributed to cigarette smoking. Treatment of SCC remains a major challenge and therapeutic advances in SCC have lagged behind those for lung adenocarcinoma. New drug targets for SCC therapy are urgently needed. Identifying functional mutations in SCC patients would enable development of new targeted therapies and enhance immunotherapy, and is the primary goal of this proposal. Many mutations have been identified from genomic analysis of human lung cancer but no assays are currently available to systematically test their functional roles in tumor development in vivo. Our proposal will overcome this major hurdle by screening for functional mutations by combining mouse models of lung cancer with the genome-editing CRISPR technology and a new technique called Tuba-seq. Tuba-seq provides a fast and precise way to quantify tumor number and size and determine the impact of genes on tumor development. This new platform provides a powerful tool identify driver mutations. It would also establish the foundation for recapitulating all mutations from a single SCC patient in a single mouse. In summary, our study will fill an important gap in new drug development and new modes of treatment of squamous cell lung cancer by offering novel targets. This will alleviate the huge burden caused by cigarette smoke.
The effects of school-based consultation on general education teachers' use of praise in the classroom
Creators: name: Barbarasch, Beth G.
Publisher: name: No Publisher Supplied
Year: 2013

description: Decades of research has shown that the single most effective method of improving students’ appropriate behavior in the classroom is behavioral praise, however it still continues to be one of the least used classroom practices in general education classrooms. Although teacher consultation has been deemed efficacious in improving teachers’ skills and competencies, few studies have investigated the utility of consultation on improving educators’ general classroom practices. The present study aimed to examine how teacher consultation can improve general education teachers’ use of praise in the classroom as well as the behavior functioning of their students, as perceived by the teacher. The study included thirty nine general education teachers who were assigned to one of three groups based on their baseline use of academic and behavioral praise: (1) below average rates of both academic and behavioral praise, (2) below average rates of behavioral praise and average rates of academic praise and (3) below average rates of behavioral praise and above average rates of academic praise. Moderating variables were also examined, specifically if already existing use of academic praise in the teachers’ daily practices could serve to increase their use of behavioral praise following consultation compared to teachers who use minimal academic praise at baseline. Within group effect sizes revealed that teachers’ use of academic and behavioral praise significantly increased following consultation in all three groups. Analysis of Covariance (ANCOVA) did not reveal any differences between groups at post-test, indicating that pre-existing use of academic praise did not serve as a moderator to improving behavioral praise. While teachers reported improvements in their own behavior, they did not report improvements in their students’ behavior functioning from baseline to post test. Implications for research and practice are outlined.
Desoria zlotini Martynova 1968
Creators: name: Mayvan, Mahmood Mehrafrooz
name: Greenslade, Penelope
name: Sadeghi-Namaghi, Hussein
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Entomobryomorpha
Isotomidae
Desoria
Desoria zlotini

description: Desoria zlotini Martynova, 1968
– Desoria zlotini Martynova, 1968b: 1560.
KS: Amiri & Kahrarian 2015; Kahrarian et al. 2016b.
Ecology and habitat in Iran: soil and leaf litter under pine and oak trees.
General distribution: Kirghisia, Tajikistan, Mongolia (Potapov 2001) and Iran.
Genus Isotoma Bourlet, 1839
description: Published as part of Mayvan, Mahmood Mehrafrooz, Greenslade, Penelope & Sadeghi-Namaghi, Hussein, 2023, An annotated checklist of the Collembola (Hexapoda) from Iran, pp. 1-101 in Zootaxa 5275 (1) on page 46, DOI: 10.11646/zootaxa.5275.1.1, http://zenodo.org/record/7898948
Cotycicuiara multicava Martins & Galileo 2010
Creators: name: Groll, Elisa Von
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Cotycicuiara
Cotycicuiara multicava

description: Cotycicuiara multicava Martins & Galileo, 2010
Martins & Galileo, 2010:2, fig. 2.
Paratype ♂, BRAZIL, Minas Gerais: Lavras, 20.X.1987, R. C. Garcia col. (MCNZ 237.053).
description: Published as part of Groll, Elisa Von, 2017, Catalogue of Coleoptera type specimens housed in the collection of the Museu de Ciências Naturais, Fundação Zoobotânica do Rio Grande do Sul, Brazil, pp. 439-473 in Zootaxa 4318 (3) on page 450, DOI: 10.11646/zootaxa.4318.3.2, http://zenodo.org/record/887750
Effects of tobacco and e-cigarettes on heart repair and regeneration
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Myocardial infarction (also called heart attack) is the major cause of heart failure, which continues to be the
 leading cause of death in the United States and developed countries around the world. The use of tobacco
 and other tobacco products increases the risk of heart diseases. The fundamental problem leading to heart
 failure is that human hearts cannot regenerate after heart injury (e.g. heart attack). It is not clear how tobacco
 smoke affects the capacity of the heart to repair after cardiac injury and increases the chances of developing
 heart failure. Furthermore, the use of e-cigarettes has gained popularity among young people. E-cigarettes
 create vapor containing toxic chemicals. The lymphatic vasculature is a specialized network of vessels that
 drains fluid from tissues and enables immune-cell clearance throughout the body. It has been shown that
 cardiac lymphatics are essential for heart repair and regeneration after heart injury in a mouse model of
 myocardial infarction. We propose to test a hypothesis that tobacco can not only increase the chances of a
 first-time heart attack but can also affect heart repair and regeneration after myocardial infarction by
 regulating the cardiac lymphatic system. We propose to 1) determine the effects of tobacco and e-cigarettes
 in zebrafish heart regeneration and cardiac lymphatic vessel functions; 2) determine the effects of tobacco
 smoke on mouse heart repair, fibrotic scar formation and development of heart failure. Our studies will reveal
 potential mechanisms on how tobacco and e-cigarettes affect heart repair after myocardial infarction and
 influence the likelihood in developing heart failure.
Caryocolum habeleri Huemer 2020
Creators: name: Bryner, Rudolf
name: Kopp, Andreas
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Gelechiidae
Caryocolum
Caryocolum habeleri

description: 3701f Caryocolum habeleri Huemer, 2020 – GR
Huemer (2020b): Alpine Entomology 4: 58.
description: Published as part of Bryner, Rudolf & Kopp, Andreas, 2023, Aktualisierung der Checkliste der Schmetterlinge (Lepidoptera) der Schweiz, pp. 39-60 in Entomo Helvetica 16 on page 50
Cotycicuiara nivaria Martins & Galileo 2010
Creators: name: Groll, Elisa Von
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Cotycicuiara
Cotycicuiara nivaria

description: Cotycicuiara nivaria Martins & Galileo, 2010
Martins & Galileo, 2010:4, fig. 4.
Paratype ♀, BRAZIL, Bahia: Porto Seguro (Arraial d’Ajuda, 20 m), VIII.2008, V. O. Becker col. (MCNZ 237.055).
description: Published as part of Groll, Elisa Von, 2017, Catalogue of Coleoptera type specimens housed in the collection of the Museu de Ciências Naturais, Fundação Zoobotânica do Rio Grande do Sul, Brazil, pp. 439-473 in Zootaxa 4318 (3) on page 450, DOI: 10.11646/zootaxa.4318.3.2, http://zenodo.org/record/887750
Novel Immunotherapeutics for Cigarette-Smoking Associated Acute Myeloid Leukemia
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Acute Myeloid Leukemia (AML) is the most common type of acute leukemia in adults. Smoking cigarettes leads to an increased risk of developing AML. The five-year survival rate for AML is less than 30% for adult patients. Novel treatment strategies with significantly enhanced efficacy are still urgently required. Compared with conventional chemotherapy, therapeutic agents that can effectively activate the immune system to robustly destroy AML cells have emerged as increasingly important anti-cancer therapies, which is attributed to their remarkable therapeutic efficacy and specificity.

 Herein, we propose to develop a novel class of therapeutics that can selectively redirect and activate the immune cells against AML cells. This project addresses the TRDRP research priority of Cancer Prevention, Treatment, and Biology through promoting high-impact translational research aimed at bringing new therapies and patient care strategies to community clinical settings. Specifically, we creatively combine knowledge and technologies from cell biology, protein engineering, and nanotechnology to rationally design and generate innovative nanoparticles with the power to control the immune system for potent and selective attacking of AML cells. Successful completion of this work will lead to the development of a new class of therapeutic regimens for better treatment of AML as well as a generally applicable and versatile platform for producing next-generation immunotherapeutics that are able to combat many other types of cancer. The findings from these preclinical studies as proof of concept will provide the basis for clinical trials. The developed innovative immunotherapeutics with excellent pharmacological properties are expected to benefit Californians with cigarette-smoking related AML.
Additional file 2: of Values, preferences and current hepatitis B and C testing practices in low- and middle-income countries: results of a survey of end users and implementers
Creators: name: Reipold, Elena
name: Trianni, Alessandra
name: Krakower, Douglas
name: Ongarello, Stefano
name: Roberts, Teri
name: Easterbrook, Philippa
name: Denkinger, Claudia
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Text file in Microsoft Word containing tables describing HCV treatment availability and testing strategies used across different testing programmes. (DOCX 23Â kb)
Isotoma anglicana Lubbock 1862
Creators: name: Mayvan, Mahmood Mehrafrooz
name: Greenslade, Penelope
name: Sadeghi-Namaghi, Hussein
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Entomobryomorpha
Isotomidae
Isotoma
Isotoma anglicana

description: Isotoma anglicana Lubbock, 1862
– Isotoma Anglicana Lubbock, 1862: 596.
IL: Shayanmehr et al. 2017.
Ecology and habitat in Iran: soil and leaf litter under scotch (Pinus sylvestris), oak and pine trees.
General distribution: Holarctic (Babenko et al. 2019).
description: Published as part of Mayvan, Mahmood Mehrafrooz, Greenslade, Penelope & Sadeghi-Namaghi, Hussein, 2023, An annotated checklist of the Collembola (Hexapoda) from Iran, pp. 1-101 in Zootaxa 5275 (1) on page 46, DOI: 10.11646/zootaxa.5275.1.1, http://zenodo.org/record/7898948
Psychometrics of the SDQ in Spanish
Creators: name: Blumert, Heather Marie
Publisher: name: No Publisher Supplied
Year: 2013

description: ABSTRACT    With the recent influx of Latinos into the United States, it is essential to understand how their backgrounds and cultures will affect the way they view their children’s emotional, social, and educational development.  Researchers continue to evaluate the psychometrics of various screening instruments in order to ensure a reliable and valid Spanish-language instrument is being used to measure children’s behaviors.  The purpose of this study was to compare the psychometric properties of the Spanish version with the English version of the Strengths and Difficulties Questionnaire (SDQ), a 25-item behavioral screener. Participants included in this study were 488 English-speaking parents and 435 Spanish-speaking parents of preschool age children (ages 3-5) that took part in the California University (Irvine) Initiative for the Development of Attention and Readiness (CUIDAR) program from 2004-2008.  This study used data from the CUIDAR program to explore mean rating differences between the English and Spanish versions of the SDQ, along with coefficient alpha as an indicator of reliability at the scale and composite level, and factor analytic evidence of score validity.  Confirmatory factor analysis was used to compare the relative fit of multiple models, including the Five First Order Factor (5F) Model that is prevalent in research on the SDQ.  Results indicated mean ratings of the individual scales and the Total Difficulties scales were very similar across both language forms.  Reliability coefficients indicated alphas were higher for the English forms compared to the Spanish forms at the scale and composite level, although neither form had adequate reliability at the scale level. Finally, the 5F Model was the best-fitting and most valid representation of all 25 items of the SDQ, despite the language of the form.  The English models also fit the proposed factor structure better than the Spanish models did.
miR-200 MicroRNAs in Lung cancer metastasis
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Lung cancer is the leading cause of cancer death worldwide, largely due to its highly aggressive and metastatic nature. Tobacco consumption is a major risk for lung cancer, contributing to 80% to 90% of lung cancer cases in the United States. In particular, long-term cigarette smoking leads to dysregulation of cellular processes and molecular network in airway epithelia, strongly promoting lung cancer initiation, progression and metastasis, and enhancing its mortality. While a lot of research has elucidated how smoking promote lung cancer initiation and progression, the cellular and molecular mechanism through which smoking negatively impacts lung cancer metastasis remains largely unknown. Multiple lines of evidence demonstrated that the exposure to cigarette smoke significantly alters the expression of non-coding RNAs, particularly microRNAs (miRNAs). Interestingly, our preliminary results suggest that some miRNAs that are strongly repressed by cigarette smoking act as key repressors for lung cancer metastasis. Hence, I hypothesize that cigarette smoking plays an essential role in promoting lung cancer metastasis, at least in part, by repressing specific miRNAs. miR-200 miRNAs are a family of five conserved miRNAs that are highly expressed in normal lung and gut epithelial cells. Multiple studies have demonstrated a marked miR-200 downregulation by exposures to cigarette smoke in human bronchial epithelia cells, sputum and serum. Downregulation of miR-200 is also observed in oral tumor when patients have a history of tobacco chewing/smoking. In our preliminary studies, a marked miR-200 decrease is not only observed in metastatic lung tumors in a mouse lung adenocarcinomas model, but also associated with poor patient survival in human lung adenocarcinoma patients. More importantly, miR-200 deficiency in a Kras-driven, p53 deficient lung adenocarcinoma model strongly promotes spontaneous lung cancer metastasis in vivo. Collectively, I hypothesize that miR-200 downregulation is likely to act downstream of cigarette smoking to promote lung cancer metastasis. Using mouse tumor models, genomics, cell and molecular biology approaches, I propose to elucidate the molecular mechanism underlying miR-200 downregulation by smoking, providing biomarker and therapeutic target for smoker lung cancer patients in diagnosis and treatment for metastatic lung adenocarcinoma.
Curuapira tuberosa Galileo & Martins 2003
Creators: name: Groll, Elisa Von
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Curuapira
Curuapira tuberosa

description: Curuapira tuberosa Galileo & Martins, 2003
Galileo & Martins, 2003a:160, fig. 1.
Paratype ♀, BRAZIL, Espírito Santo: Linhares (Parque Sooretama), X.1967, F. M. Oliveira col. (MCNZ 233.952).
description: Published as part of Groll, Elisa Von, 2017, Catalogue of Coleoptera type specimens housed in the collection of the Museu de Ciências Naturais, Fundação Zoobotânica do Rio Grande do Sul, Brazil, pp. 439-473 in Zootaxa 4318 (3) on page 450, DOI: 10.11646/zootaxa.4318.3.2, http://zenodo.org/record/887750
Mazama pandora Merriam 1901
Creators: name: Don E. Wilson
name: Russell A. Mittermeier
Publisher: name: Lynx Edicions
Year: 2011
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Artiodactyla
Cervidae
Mazama
Mazama pandora

description: 45.
Yucatan Brown Brocket
Mazama pandora
French: Cariacou du Yucatan / German: Yucatan-Mazama / Spanish: Corzuela de Yucatan
Taxonomy. Mazama pandora Merriam, 1901,
Tunkas, Yucatan (Mexico).
It has been considered a subspecies of M. gouazoubira and of M. americana. Monotypic.
Distribution. Yucatan Peninsula (Mexico); possibly also in N Guatemala and N Belize.
Descriptive notes. Few measuremets available. Shoulder height 70 cm; weight 17-21 kg. Medium-sized brocket, slightly larger than the sympatric Mexican Red Brocket (M. temama). The main color of the coatis gray-brown, with pale brown to whitish underparts. A tuft of stiff hairs grows on the forehead. Relatively long antlers, longitudinally furrowed; antler tips may curve inward.
Habitat. It is a generalist, able to live in wet and dry forests as well as shrublands, with a preference for tall and medium semi-evergreen forests. It also occurs in mangrove forests, above high tide level. In populated areas,it will sometimes enter into agricultural plantations to feed.
Food and Feeding. It is mainly frugivorous, but feeds on a wide range of plants. The diet is richer in species during the wet season.
Breeding. It seems to breed during most of the year.
Activity patterns. Nothing is known of the daily activity patterns, but almost surely crepuscular. In addition, it may be active at other times of the day and night, depending on hunting pressure.
Movements, Home range and Social organization. It lives in small home ranges and is basically solitary.
Status and Conservation. Classified as Vulnerable on The IUCN Red List. It is globally declining. Overhunting and habitat loss are the main threats.
Bibliography. Medellin et al. (1998), Weber & Medellin (2010), Weber et al. (2008).
description: Published as part of Don E. Wilson & Russell A. Mittermeier, 2011, Cervidae, pp. 350-443 in Handbook of the Mammals of the World – Volume 2 Hoofed Mammals, Barcelona :Lynx Edicions on page 441, DOI: 10.5281/zenodo.6514377
Additional file 2: of One or two serological assay testing strategy for diagnosis of HBV and HCV infection? The use of predictive modelling
Creators: name: Parry, John
name: Easterbrook, Philippa
name: Sands, Anita
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Outcomes from applying 1- and 2-test diagnostic strategy models to four HCV epidemic scenarios (DOCX 953Â kb)
Desmiphora (Distenia) amioca Galileo & Martins 1998
Creators: name: Groll, Elisa Von
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Desmiphora
Desmiphora amioca

description: Desmiphora (D.) amioca Galileo & Martins, 1998
Galileo & Martins, 1998a:39, fig. 7.
Paratype ♀, BRAZIL, Mato Grosso: Sinop, (BR-163, km 500 a 600, 12°31’S, 55°37’W), IX.1974, Alvarenga & Roppa col. (MCNZ 233.953).
description: Published as part of Groll, Elisa Von, 2017, Catalogue of Coleoptera type specimens housed in the collection of the Museu de Ciências Naturais, Fundação Zoobotânica do Rio Grande do Sul, Brazil, pp. 439-473 in Zootaxa 4318 (3) on page 451, DOI: 10.11646/zootaxa.4318.3.2, http://zenodo.org/record/887750
Isotoma iranica Arbea & Kahrarian 2015
Creators: name: Mayvan, Mahmood Mehrafrooz
name: Greenslade, Penelope
name: Sadeghi-Namaghi, Hussein
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Collembola
Entomobryomorpha
Isotomidae
Isotoma
Isotoma iranica

description: Isotoma iranica Arbea & Kahrarian, 2015
– Isotoma iranica Arbea & Kahrarian, 2015b: 77.
KS: Arbea & Kahrarian 2015b; GO: Yoosefi Lafooraki et al. 2020b.
Ecology and habitat in Iran: soil.
General distribution: species known only from type locality (Arbea & Kahrarian 2015b).
description: Published as part of Mayvan, Mahmood Mehrafrooz, Greenslade, Penelope & Sadeghi-Namaghi, Hussein, 2023, An annotated checklist of the Collembola (Hexapoda) from Iran, pp. 1-101 in Zootaxa 5275 (1) on page 46, DOI: 10.11646/zootaxa.5275.1.1, http://zenodo.org/record/7898948
The Effects of Electronic Hookah on Endothelial Cell Function: The Role of Nicotine
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Electronic nicotine delivery systems (ENDS) are growing quickly in the United States and around the world. Recently, electronic (e-) hookahs are becoming more popular, particularly among young females, who belief that these products are safer than traditional flavored hookah tobacco smoking. Unlike other ENDS such as e-cigarettes, e-hookah bowls are used through traditional water-pipes, allowing the smoke—containing nicotine, propylene glycol, glycerin, and flavorings—to pass through a water-filled base, possibly modifying the smoke, before it is inhaled through the user’s mouth. Contributing to e-hookah bowls’ popularity is the belief that e-hookah flavored smoke is filtered as it passes through the water, claiming e-hookah a safer tobacco alternative. However, an e-hookah bowl exposes the user to flavored nicotine by producing smoke containing a complex mixture of extremely small particles carrying toxins inside that could result in vascular toxicity. The goal of this grant proposal is to study the effects of e-hookah bowl inhalation on humans’ blood vessel function and biological vascular markers; and underlying process by which e-hookah lead to damage to the protective functions of endothelial cells, which line the inside of blood vessels and the heart. In a cross-over study design, we will first study blood vessel function by ultrasound imaging measurements of the main artery of the upper arm and collect biological markers of oxidants and inflammation in 18 young healthy hookah smokers 21-39 years old, before and after two separate 30-minute e-hookah bowl inhalation sessions using one brand of nicotine-containing and nicotine-free e-hookah liquid and, for control comparison, before and after sham hookah smoking. Then, in freshly collected endothelial cells before and after the sessions we will study production of nitric oxide and markers of inflammation and oxidative stress. To compare exposures across sessions, we will measure levels of nicotine, and toxic chemicals: acrolein and benzene. Findings from this study will help provide important data on the effects of e-hookah inhalation on vascular health and underlying causes of how e-hookah exposure may impact vascular health. Our findings will provide important information to the FDA and policymakers to create stricter laws specific to hookah.