cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Imaging spectrum of the appearance of normal bone marrow on MRI
Creators: name: Aquilina, Veronica
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Education and training
subject: Normal variants
subject: Imaging sequences
subject: MR
subject: Musculoskeletal system
subject: Musculoskeletal bone
subject: Bones

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The aim of this educational exhibit is: To present the normal appearance of the vertebral and appendicular bone marrow on MRI, in relation to the normal composition and physiology of bone marrow. To present examples of focal and diffuse bone marrow...
Quantum phase transition as an interplay of Kitaev and Ising interactions
Creators: name: Langari, A.
name: Mohammad-Aghaei, A.
name: Haghshenas, R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We study the interplay between the Kitaev and Ising interactions on both ladder and two dimensional lattices. We show that the ground state of the Kitaev ladder is a symmetry-protected topological (SPT) phase, which is protected by a $\mathbb{Z}_2 \times \mathbb{Z}_2$ symmetry. It is confirmed by the degeneracy of the entanglement spectrum and non-trivial phase factors (inequivalent projective representations of the symmetries), which are obtained within infinite matrix-product representation of numerical density matrix renormalization group. We derive the effective theory to describe the topological phase transition on both ladder and two-dimensional lattices, which is given by the transverse field Ising model with/without next-nearest neighbor coupling. The ladder has three phases, namely, the Kitaev SPT, symmetry broken ferro/antiferromagnetic order and classical spin-liquid. The non-zero quantum critical point and its corresponding central charge are provided by the effective theory, which are in full agreement with the numerical results, i.e., the divergence of entanglement entropy at the critical point, change of the entanglement spectrum degeneracy and a drop in the ground-state fidelity. The central charge of the critical points are either c=1 or c=2, with the magnetization and correlation exponents being 1/4 and 1/2, respectively. In the absence of frustration, the 2D lattice shows a topological phase transition from the $\mathbb{Z}_2$ spin-liquid state to the long-range ordered Ising phase at finite ratio of couplings, while in the presence of frustration, an order-by-disorder transition is induced by the Kitaev term. The 2D classical spin-liquid phase is unstable against the addition of Kitaev term toward an ordered phase before the transition to the $\mathbb{Z}_2$ spin-liquid state.
description: 16 pages, 18 figures
Synergistic effect of the anti-PD-1 antibody with blood stable and reduction sensitive curcumin micelles on colon cancer
Creators: name: Gong, Feirong
name: Ma, Jian-Chao
name: Jia, Jianguo
name: Li, Fa-Zhan
name: Wu, Jiao-Lan
name: Wang, Shanfeng
name: Teng, Xin
name: Cui, Zhong-Kai
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) is a potent anticancer drug with versatile biological activities, while the clinical translation of curcumin is severely limited due to its hydrophobicity, rapid elimination, and metabolism in the blood circulation. Herein, we aim to unravel the potential of curcumin as a synergistic agent with immunotherapy in the treatment of cancers. In an effort to minimize premature release and improve the systemic bioavailability, a superior blood stable and reduction sensitive curcumin micellar formulation, of which the release can be triggered by cancer cells, is rationally designed. We have synthesized a telodendrimer (mPEG-PLA-(LA)4) capable of forming reversible disulfide crosslinked micelles (DCMs). The curcumin loaded DCMs (Cur/DCMs) are spherical with a uniform size of 24.6 nm. The in vitro release profile demonstrates that curcumin releases significantly slower from DCMs than that from non-crosslinked micelles (NCMs), while the release can be accelerated with the increasing concentration of reducing agent glutathione (GSH). Intravenous administration of Cur/DCMs stably retains curcumin in the bloodstream and efficiently improves the systemic bioavailability. Furthermore, Cur/DCMs exhibit synergistic anticancer efficacy when combined with the anti-PD-1 antibody in an MC-38 colon cancer xenograft model. Our results potentiate the integration of blood stable curcumin nanoformulation and immunotherapy for cancer treatment.
Simulations Suggest Pharmacological Methods for Rescuing Long-Term Potentiation
Creators: name: Smolen, Paul
name: Baxter, Douglas A.
name: Byrne, John H.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Neurons and Cognition (q-bio.NC)
subject: FOS: Biological sciences

description: Congenital cognitive dysfunctions are frequently due to deficits in molecular pathways that underlie synaptic plasticity. For example, Rubinstein-Taybi syndrome (RTS) is due to a mutation in cbp, encoding the histone acetyltransferase CREB-binding protein (CBP). CBP is a transcriptional co-activator for CREB, and induction of CREB-dependent transcription plays a key role in long-term memory (LTM). In animal models of RTS, mutations of cbp impair LTM and late-phase long-term potentiation (LTP). To explore intervention strategies to rescue the deficits in LTP, we extended a previous model of LTP induction to describe histone acetylation and simulated LTP impairment due to cbp mutation. Plausible drug effects were simulated by parameter changes, and many increased LTP. However no parameter variation consistent with a biochemical effect of a known drug fully restored LTP. Thus we examined paired parameter variations. A pair that simulated the effects of a phosphodiesterase inhibitor (slowing cAMP degradation) concurrent with a deacetylase inhibitor (prolonging histone acetylation) restored LTP. Importantly these paired parameter changes did not alter basal synaptic weight. A pair that simulated a phosphodiesterase inhibitor and an acetyltransferase activator was similarly effective. For both pairs strong additive synergism was present. These results suggest that promoting histone acetylation while simultaneously slowing the degradation of cAMP may constitute a promising strategy for restoring deficits in LTP that may be associated with learning deficits in RTS. More generally these results illustrate the strategy of combining modeling and empirical studies may help design effective therapies for improving long-term synaptic plasticity and learning in cognitive disorders.
description: 21 pages, 4 figures
title: Venous ports associated thrombosis: incidence, risk factors and management
Creators: name: Cherkashin, Mikhail
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Vascular
subject: Oncology
subject: Interventional vascular
subject: CT
subject: Ultrasound-Colour Doppler
subject: Venous access
subject: Complications
subject: Outcomes analysis
subject: Embolism / Thrombosis
subject: Patterns of Care
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To assess venous thromboembolism incidence in patients with port-systems. To identify VTE risk factors and to develop management strategy Port-systems are known to create the high riskfor the development of venous thromboembolism...
Time-evolving a matrix product state with long-ranged interactions
Creators: name: Zaletel, Michael P.
name: Mong, Roger S. K.
name: Karrasch, Christoph
name: Moore, Joel E.
name: Pollmann, Frank
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We introduce a numerical algorithm to simulate the time evolution of a matrix product state under a long-ranged Hamiltonian. In the effectively one-dimensional representation of a system by matrix product states, long-ranged interactions are necessary to simulate not just many physical interactions but also higher-dimensional problems with short-ranged interactions. Since our method overcomes the restriction to short-ranged Hamiltonians of most existing methods, it proves particularly useful for studying the dynamics of both power-law interacting one-dimensional systems, such as Coulombic and dipolar systems, and quasi two-dimensional systems, such as strips or cylinders. First, we benchmark the method by verifying a long-standing theoretical prediction for the dynamical correlation functions of the Haldane-Shastry model. Second, we simulate the time evolution of an expanding cloud of particles in the two-dimensional Bose-Hubbard model, a subject of several recent experiments.
description: 5 pages + 3 pages appendices, 4 figures
Antidiabetic (α-amylase and α-glucosidase) and anti-obesity (lipase) inhibitory activities of edible cassava (Manihot esculenta Crantz) as measured by in vitro gastrointestinal digestion: effects of phenolics and harvested time
Creators: name: Laya, Alphonse
name: Koubala, Benoît B.
name: Negi, Pradeep S.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: Edible cassava leaves (Manihot esculenta) were consumed as vegetables for their bioactive compounds, however the effect of harvesting time on these bioactive compounds and their antidiabetic and anti-obesity inhibitory activities were scarcely reported in the literature. Phenolics from edible leaves harvested at different times were assessed using HPLC-DAD, and their antidiabetic and anti-obesity inhibitory activities were investigated before and after in vitro gastrointestinal digestion. The results showed a significant (P < .05) effect of harvesting time on phenolic contents. Bound phenolics showed higher lipase inhibitory activity than their free fractions. However, phenolic contents decreased after in vitro digestion, while they showed high antidiabetic and anti-obesity inhibitory activities. The present study demonstrated that edible leaves harvested at different times are rich in flavonoids, stilbenes, tannins and saponins. These bioactive compounds are highly potent against α-amylase, α-glucosidase and lipase before and after in vitro gastrointestinal digestion. Therefore, we recommend edible cassava leaves for important biological active compounds for the prevention of obesity and type 2 diabetes.
Radiating Current Sheets in the Solar Chromosphere
Creators: name: Goodman, Michael L.
name: Judge, Philip G.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Plasma Physics (physics.plasm-ph)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: An MHD model of a Hydrogen plasma with flow, an energy equation, NLTE ionization and radiative cooling, and an Ohm's law with anisotropic electrical conduction and thermoelectric effects is used to self-consistently generate atmospheric layers over a $50$ km height range. A subset of these solutions contain current sheets, and have properties similar to those of the lower and middle chromosphere. The magnetic field profiles are found to be close to Harris sheet profiles, with maximum field strengths $\sim 25-150$ G. The radiative flux $F_R$ emitted by individual sheets is $\sim 4.9 \times 10^5 - 4.5 \times 10^6$ ergs-cm$^{-2}$-s$^{-1}$, to be compared with the observed chromospheric emission rate of $\sim 10^7$ ergs-cm$^{-2}$-s$^{-1}$. Essentially all emission is from regions with thicknesses $\sim 0.5 - 13$ km containing the neutral sheet. About half of $F_R$ comes from sub-regions with thicknesses 10 times smaller. A resolution $\lesssim 5-130$ m is needed to resolve the properties of the sheets. The sheets have total H densities $\sim 10^{13}-10^{15}$ cm$^{-3}$. The ionization fraction in the sheets is $\sim 2-20$ times larger, and the temperature is $\sim 2000-3000$ K higher than in the surrounding plasma. The Joule heating flux $F_J$ exceeds $F_R$ by $\sim 4-34 \%$, the difference being balanced in the energy equation mainly by a negative compressive heating flux. Proton Pedersen current dissipation generates $\sim 62-77\%$ of the positive contribution to $F_J$. The remainder of this contribution is due to electron current dissipation near the neutral sheet where the plasma is weakly magnetized.
description: 29 pages, 11 figures
title: CT- guided transthoracic lung biopsy: a comparison of a co-axial core biopsy with non co-axial fine needle aspiration biopsy and factors influencing complications
Creators: name: PEKER, AHMET
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Interventional non-vascular
subject: Thorax
subject: Oncology
subject: CT
subject: Biopsy
subject: Cancer
subject: Tissue characterisation
subject: Haemorrhage

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Lung cancer is one of the most common causes of cancer-related death worldwide. With the widespread use of CT, increasing number of lung lesions are detected and histological diagnosis is often necessary to determine the most appropriate management...
Structural characteristics of collagen from cuttlefish skin waste extracted at optimized conditions
Creators: name: Hazeena, Sulfath Hakkim
name: Shih, Ming-Kuei
name: Hsieh, Shu-Ling
name: Hsieh, Chang-Wei
name: Liu, Tsu Tung
name: Chen, Min-Hung
name: Huang, Yu-Wen
name: Hou, Chih-Yao
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Aquatic by-products during fish processing cause environmental pollution and increase disposal costs. Cuttlefish skin is one of the major by-products of cuttlefish (Sepia pharaonis) processing and is generally thrown as a by-product. It can cause severe environmental problems and odor. It has been discovered that cuttlefish skin can be an excellent resource for producing attractive amounts of collagen. This study optimized collagen extraction conditions using response surface methodology (RSM). In addition, SDS-PAGE, specific charge, and scanning electron microscopy (SEM) characteristics of extracted collagen were evaluated. The results showed that the optimal extraction conditions for cuttlefish skin collagen are pH 1.5, 20 mg/L (solid-liquid ratio), 15 U/mg (Pepsin), and the average extraction rate can be obtained as 8.79%. The results of LC/MS/MS analysis of the collagen samples extracted in this study showed that the main m/z signal of proline produced by mass spectrometry was between 2000–4000. Collagen extracted from the cuttlefish skin is type I collagen, which consists of 2 α chains and 1 β chain (α2, α1, β). SEM analysis of collagen confirmed the presence of collagen fibrils in the cuttlefish skin similar to previous reports. Using the response surface methodology, optimal collagen extraction conditions pH 1.5, 20 mg/L (solid-liquid ratio), and 15 U/mg (Pepsin) can be obtained to recycle and utilize by-products.
Short-term Forecasting of Anomalous Load Using Rule-based Triple Seasonal Methods
Creators: name: Arora, Siddharth
name: Taylor, James W.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: Numerous methods have been proposed for forecasting load for normal days. Modeling of anomalous load, however, has often been ignored in the research literature. Occurring on special days, such as public holidays, anomalous load conditions pose considerable modeling challenges due to their infrequent occurrence and significant deviation from normal load. To overcome these limitations, we adopt a rule-based approach, which allows incorporation of prior expert knowledge of load profiles into the statistical model. We use triple seasonal Holt-Winters-Taylor (HWT) exponential smoothing, triple seasonal autoregressive moving average (ARMA), artificial neural networks (ANNs), and triple seasonal intraweek singular value decomposition (SVD) based exponential smoothing. These methods have been shown to be competitive for modeling load for normal days. The methodological contribution of this paper is to demonstrate how these methods can be adapted to model load for special days, when used in conjunction with a rule-based approach. The proposed rule-based method is able to model normal and anomalous load in a unified framework. Using nine years of half-hourly load for Great Britain, we evaluate point forecasts, for lead times from one half-hour up to a day ahead. A combination of two rule-based methods generated the most accurate forecasts.
description: 8 Pages, 11 Figures
Directional and dynamic modulation of the optical emission of an individual GaAs nanowire using surface acoustic waves
Creators: name: Kinzel, Jörg B.
name: Rudolph, Daniel
name: Bichler, Max
name: Abstreiter, Gerhard
name: Finley, Jonathan J.
name: Koblmüller, Gregor
name: Wixforth, Achim
name: Krenner, Hubert J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We report on optical experiments performed on individual GaAs nanowires and the ma- nipulation of their temporal emission characteristics using a surface acoustic wave. We find a pronounced, characteristic suppression of the emission intensity for the surface acoustic wave propagation aligned with the axis of the nanowire. Furthermore, we demonstrate that this quenching is dynamical as it shows a pronounced modulation as the local phase of the surface acoustic wave is tuned. These effects are strongly reduced for a SAW applied in the direction perpendicular to the axis of the nanowire due to their inherent one-dimensional geometry. We resolve a fully dynamic modulation of the nanowire emission up to 678 MHz not limited by the physical properties of the nanowires.
description: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Nano Letters, copyright \c{opyright} American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/nl1042775
title: Radiologic approach for neonatal intestinal obstruction
Creators: name: Ashour, Manar Maamoun Mohamed
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Outcomes
subject: Obstruction / Occlusion
subject: Congenital
subject: Barium meal
subject: Barium enema
subject: Ultrasound
subject: Digital radiography
subject: Conventional radiography
subject: Paediatric
subject: Gastrointestinal tract

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Reviewing different causes of neonatal intestinal obstruction. Reviewing an ordered radiologic approach to deal with neonatal intestinal obstruction. Recognizing radiologic signs of the different causes. Recognizing ominous signs requiring emergency...
ROS-Activated homodimeric podophyllotoxin nanomedicine with self-accelerating drug release for efficient cancer eradication
Creators: name: Liang, Bingfeng
name: Zhou, Dangxia
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Although podophyllotoxin (POD) demonstrates high efficiency to inhibit various cancers, its clinic application is limited to poor bioavailability. Nanoparticles derived from homodimeric prodrugs with high drug loading potential are emerging as promising nanomedicines. However, complete intracellular drug release remains a major hindrance to the use of homodimeric prodrugs-based nanomedicine. We sought to develop a reactive oxygen species (ROS) responsive POD dimeric prodrug by incorporating vitamin K3 (VK3) and Pluronic F127 to synthesize a spheroid nanoparticle (PTV-NPs). PTV-NPs with high POD content could release drugs under the ROS enrichment microenvironment in cancer cells. The released VK3 could produce abundant ROS selectively in tumor cells catalyzed by the overexpressed NAD(P)H: quinone oxidoreductase-1 (NQO1) enzyme. In turn, the resultant high ROS concentration promoted the conversion of POD dimeric prodrug to POD monomer, thereby achieving the selective killing of cancer cells with weak system toxicity. In vitro and in vivo studies consistently confirmed that PTV-NPs exhibit high drug loading potential and upstanding bioavailability. They are also effectively internalized by tumor cells, induce abundant intracellular ROS generation, and have high tumor-specific cytotoxicity. This ROS-responsive dimeric prodrug nanoplatform characterized by selective self-amplification drug release may hold promise in the field of antitumor drug delivery.
title: Μελέτη της τρισδιάστατης κατανομής δόσης στην ακτινοθεραπεία, παρουσία ετερογενειών στο ανθρώπινο σώμα με τη χρήση προγραμμάτων προσομοίωσης σε Η/Υ και σύγκριση υπαρχόντων αλγορίθμων υπολογισμού δόσης με τεχνικές Monte Carlo
titleType: AlternativeTitle
Creators: name: Τσιάκαλος, Μιλτιάδης Ευάγγελος
Publisher: name: University of Thessaly
Year: 2005
Subjects: subject: ΡΑΔΙΟΘΕΡΑΠΕΙΑ
subject: ΜΕΘΟΔΟΣ MONTE CARLO

description: Στην εισαγωγή της εργασίας μας παρουσιάζονται οι βασικές έννοιες της ακτινοθεραπείας. Περιγράφεται ο γραμμικός επιταχυντής και στη συνέχεια αναφέρονται τα βασικά βήματα της διαδικασίας για την θεραπεία του ασθενή. Τα βήματα που περιγράφονται αφορούν στην τοποθέτηση του ασθενούς και την απεικόνιση της εσωτερικής του γεωμετρίας, την περιγραφή των εσωτερικών δομών ενδιαφέροντος, όπως ο στόχος και οι υγιείς ιστοί. Παρουσιάζονται επίσης και οι πιο εξειδικευμένες έννοιες του CTV και PTV με απλά λόγια ώστε ο αναγνώστης να συνεχίσει με ευκολία στην παρουσίαση του σχεδιασμού της θεραπείας. Σε αυτό το κομμάτι αναφέρονται ο τρόπος που γίνεται ο σχεδιασμός και περιγράφονται οι παράμετροι της δέσμης που μπορεί να αλλάξει ο σχεδιαστής ενός πλάνου ώστε να επιτύχει την βέλτιστη κατανομή δόσης μέσα στον ασθενή. Ακολουθεί η αξιολόγηση του πλάνου θεραπείας και η περιγραφή των μέσων που έχει ο χρήστης στην διάθεση του. Γίνεται αναφορά στις ισοδοσιακές καμπύλες στα διάφορα επίπεδα καθώς επίσης και στα ιστογράμματα δόσης όγκου (DVH). Ακολουθεί μια περιγραφή της εφαρμογής και του τρόπου επαλήθευσης του πλάνου θεραπείας. Το κεφάλαιο κλείνει με μια σύντομη παρουσίαση του τρόπου υπολογισμού της δόσης που λαμβάνει ο ασθενής τονίζοντας την ακρίβεια που απαιτείται για αυτή και αναφέρει κάποιους προβληματισμούς που προέκυψαν κατά την παρούσα ερευνά μας στο θέμα που αφορά τον ποιοτικό έλεγχο των εργαλείων που χρησιμοποιούνται για τον υπολογισμός της δόσης
Degenerate gaugino mass region and mono-boson collider signatures
Creators: name: Anandakrishnan, Archana
name: Carpenter, Linda M.
name: Raby, Stuart
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: In this paper we discuss search strategies at the LHC for light electroweak gauginos which are mostly Wino-like, Higgsino-like or an admixture. These states are typically degenerate with decay products that are less energetic and hence difficult to detect. In addition, their production cross-sections at a hadron collider are suppressed compared to colored states such as the gluinos. In order to detect these states one needs to trigger on initial or final state radiation. Many previous analyses have focussed on mono-jet and mono-photon triggers. In the paper we argue and show that these triggers are unlikely to succeed, due to the large background from QCD backgrounds for the mono-jet searches and the fact that the $p_T$ distribution of the mono-photons are rapidly decreasing functions of $p_T$. We show this with both an analytic calculation of photons in the initial state radiation and also a detailed numerical analysis. We then argue that mono-Z triggers, from Z decaying into charged leptons may well provide the best search strategy, in particular for Higgsino-like and mixed cases.
A mechanism for improved talc pleurodesis via foam delivery
Creators: name: Lima, T. A.
name: Coler, R. A.
name: Laub, G. W.
name: Sexton, S.
name: Curtin, L.
name: Laub, K. M.
name: Alvarez, N. J.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Talcum powder is recognized as the leading drug for pleurodesis, a treatment of choice for malignant pleural effusions. Recently, it was shown that hydrogel foam delivery systems significantly enhanced the number of adhesions between the chest wall and the lung in a New Zealand rabbit model due to the sol-gel transition. However, many questions still remain regarding the cause of improved efficacy, such as: (1) Would only hydrogel foams improve the efficacy of talc pleurodesis? (2) Is it possible to achieve the same efficacy of hydrogels using non-hydrogel foams? 3) What are the physicochemical properties that can be correlated to the efficacy of talc pleurodesis? In this study, we use non-hydrogel foam formulations to determine the efficacy of pleurodesis. Foam stability and rheology of the formulations were correlated to adhesion formation. The results clearly suggest a correlation of pleurodesis efficacy to the viscosity and modulus of the foam delivery system.
Small molecules putative structure elucidation in endemic Colombian fruits: CFM-ID approach
Creators: name: Ramirez, Daniel Arias
name: Carazzone, Chiara
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: The main goal of any structural elucidation process is to achieve the highest level of confidence possible. This is usually attained using identical standards that can confirm the unequivocal structure of a metabolite. Nevertheless, the use of standards is not always possible given the great structural diversity among bioactive compounds. To overcome this problem, informatics tools can be used, such as the open source “CFM-ID” for structure elucidation, along with a meticulous mass fragmentation analysis as an initial step for putative identification. Herein, the “CFM-ID” tool was used on three Colombian fruits especially rich in phenolic compounds: Bactris gasipaes, Borojoa patinoi, and Myrciaria dubia. Thus, we obtained the characterization of new metabolites. To complete this picture, the bioactive content was measured using in-vitro assays (antioxidant, anti-inflammatory, and neuroprotective) with promising results, and was eventually related to the twenty-six new compounds reported here for the first time.
N-oleoylethanolamine − phosphatidylcholine complex loaded, DSPE-PEG integrated liposomes for efficient stroke
Creators: name: Yang, Xiangrui
name: Wu, Shichao
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Causing more and more deaths, stroke has been a leading cause of death worldwide. However, success in clinical stroke trials has remained elusive. N-oleoylethanolamine (OEA) was an endogenous highly hydrophobic molecule with outstanding neuroprotective effect. In this article, hydrogen bonds were successfully formed between OEA and soybean phosphatidylcholine (SPC). The synthetic OEA-SPC complex and DSPE-PEG were self-assembled into liposomes (OEA NPs), with OEA-SPC loaded in the core and PEG formed a hydrophilic shell. Hence, highly hydrophobic OEA was loaded into liposomes as amorphous state with a drug loading of 8.21 ± 0.18 wt%. With fairly uniform size and well-distributed character, the OEA NPs were systemically assessed as an intravenous formulation for stroke therapy. The results indicated that the administration of OEA NPs could significantly improve the survival rate and the Garcia score of the MCAO rats compared with free OEA. The TTC-stained brain slices declared that the cerebral infarct volume and the edema degree induced by MCAO could be decreased to an extremely low level via the administration of OEA NPs. The Morris water maze (MWM) test suggested that the spatial learning and memory of the MCAO rats could also be ameliorated by OEA NPs. The immunofluorescence assay stated that the apoptosis of the neurons and the inflammation within the brain were greatly inhibited. The results suggest that the OEA NPs have a great chance to develop OEA as a potential anti-stroke formulation for clinic application.
Estimation of alpha-viscosity coefficient from observations of nonstationary disk accretion
Creators: name: Bisnovatyi-Kogan, G. S.
name: Klepnef, A. S.
name: Giovannelli, F.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The optical behaviour of the Be star in the high mass X-ray transient A0535+26/HDE245770 shows that at the periastron typically there is an enhancement in the luminosity of order 0.05 to few tenths mag, and the X- ray outburst happens about 8 days after the periastron. We construct a quantitative model of this event, basing on a nonstationary accretion disk behavior, connected with a high ellipticity of the orbital motion. We explain the observed time delay between the peaks of the optical and X-ray outbursts in this system by the time of radial motion of a matter in the accretion disk, after increase of the mass flux in the vicinity of a periastral point in the binary. This time is determined by the turbulent viscosity, with the parameter $ α=0.1-0.3$, estimated from the comparison of the model with observational data
description: 6 pages, 3 figures. arXiv admin note: substantial text overlap with arXiv:1305.5149
Non linear evolution: revisiting the solution in the saturation region
Creators: name: Contreras, Carlos
name: Levin, Eugene
name: Meneses, Rodrigo
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In this paper we revisit the problem of the solution to Balitsky-Kovchegov equation deeply in the saturation domain. We find that solution has the form of Levin-Tuchin solution but it depends on variable $\bar{z} = \ln(r^2 Q^2_s) + \mbox{Const}$ and the value of $\mbox{Const}$ is calculated in this paper. We propose the solution for full BFKL kernel at large $z$ in the entire kinematic region that satisfies the McLerram-Venugopalan initial condition
description: 15 pp, 8 figures in eps files
title: Communication Support and Religious Support in Managing Occupational Stress in Military Careers: A Career-Span Approach
Creators: name: Mitchell, Shantonee' Malee
Publisher: name: Old Dominion University Libraries
Year: 2025

description: This thesis reports an exploratory and descriptive study of communication support and religious support used by military personnel to manage occupational stress over the course of a career and their perceived effectiveness at helping to manage occupational stress. Drawing on a lifespan communication approach, this study employed a careerspan perspective where occupational stressors and sources of support (human and religious) are examined over the course of military careers. Results find three different groups of sources of communicative support were used in different ways to help manage military occupational stress: sources within the military, sources outside of the military, and religious sources. Also, across the career-span, some sources of support (communicative and religious) appeared only at certain times (e.g., the Bible figured in the beginning stages) whereas others were prevalent throughout the career-span (e.g., Chaplains). Looking at the various sources of communicative support that military personnel turned to, religion figured more prominently in both early years and the later years, but was also turned to far less than human communication support sources. Participants did report that communicative support they received was helpful in managing occupational stress with familial support and support of other military members as most beneficial throughout career-span.
title: Ct-guided biopsy of pulmonary lesions. Our experience with 577 cases
Creators: name: Calero Garcia, Maria
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Multidisciplinary cancer care
subject: Cancer
subject: Diagnostic procedure
subject: Biopsy
subject: Percutaneous
subject: CT
subject: Thorax
subject: Lung
subject: Interventional non-vascular

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To comprehensively describe the indications, contraindications, technical aspects, diagnostic accuracy and complication rates of conventional CT–guided lung biopsies (FNAB and CNB) in our series. To show the spectrum of imaging findings we may...
GW quasiparticle band gap of the hybrid organic-inorganic perovskite CH$_3$NH$_3$PbI$_3$: Effect of spin-orbit interaction, semicore electrons, and self-consistency
Creators: name: Filip, Marina R.
name: Giustino, Feliciano
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We study the quasiparticle band gap of the hybrid organic-inorganic lead halide perovskite CH$_3$NH$_3$PbI$_3$, using many-body perturbation theory based on the $GW$ approximation. We perform a systematic analysis of the band gap sensitivity to relativistic spin-orbit effects, to the description of semicore Pb-5$d$ and I-4$d$ electrons, and to the starting Kohn-Sham eigenvalues. We find that the inclusion of semicore states increases the calculated band gap by 0.2 eV, and self-consistency on the quasiparticle eigenvalues using a scissor correction increases the band gap by 0.4 eV with respect to the $G_0W_0$ result. These findings allow us to resolve an inconsistency between previously reported $GW$ calculations for CH$_3$NH$_3$PbI$_3$. Our most accurate band gap is 1.65 eV, and is in good agreement with the measured optical gap after considering a small excitonic shift as determined in experiments.
description: 10 pages, 4 figures
Calyxochaetus bovanodatus Runyon, 2024, sp. nov.
Creators: name: Runyon, Justin B.
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Dolichopodidae
Calyxochaetus
Calyxochaetus bovanodatus

description: Calyxochaetus bovanodatus sp. nov.
(Figs 122, 139, 144)
Type material. HOLOTYPE ♂, labeled: “ Afton: K.C. Kim / Wash. Co., Minn./ May 7 1960 ”; “HOLOTYPE/ Calyxochaetus / bovanodatus / J.B. Runyon [red label]” (USNM) (Fig. 139).
Diagnosis. This species is very similar to C. nodatus but differs in having mid tarsomeres 2–4 swollen (Fig. 122) and the position of the long ventral seta on the hind tibia.
Description. Male. Wing length 3.3 mm. Similar to C. nodatus except as noted: Thorax: Scutellum with indistinct blue-violet reflections. Legs: Midleg: Tarsus (Fig. 122) with tarsomere 2 elongate ovate, rather swollen, concave ventrally, with anteroapical projection broader and rounded. Tarsomeres 3–4 swollen and nearly round, tarsomere 3 with ventral setae smaller and straight. Hindleg: Tibia with long slender ventral seta near 1/3 (one leg has additional short slender seta near 1/5).
Female. Unknown.
Distribution and seasonal occurrence. Known only from the holotype collected at Afton, Minnesota on May 7.
Etymology. The specific epithet is from the Latin bova (a swelling of the legs) + nodatus, in reference to this species being similar to C. nodatus but having swollen mid tarsomeres.
description: Published as part of Runyon, Justin B., 2024, Revision of the genus Calyxochaetus Bigot (Diptera: Dolichopodidae: Sympycninae), pp. 1-74 in Zootaxa 5539 (1) on page 52, DOI: 10.11646/zootaxa.5539.1.1, http://zenodo.org/record/14240426
title: Carotid artery stenosis: theoretical basis and practical advices.
Creators: name: Piotrowicz, Paweł
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Obstruction / Occlusion
subject: Education and training
subject: Arteriosclerosis
subject: Diagnostic procedure
subject: Decision analysis
subject: Computer Applications-Detection, diagnosis
subject: Ultrasound-Spectral Doppler
subject: CT
subject: CT-Angiography
subject: Vascular
subject: Arteries / Aorta
subject: CNS

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The purpose of this poster is to explore the problem of carotid artery stenosis as a frequent cause of ischemic stroke, with special attention to indications for surgical or medical treatment based on wide-range clinical trials NASCES and ECST. It...
title: Biliary atresia: Background, pathogenesis and imaging manifestations.
Creators: name: Trujillo Calderon, Nasly
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Congenital
subject: Cirrhosis
subject: Screening
subject: Biopsy
subject: Ultrasound
subject: MR
subject: CT
subject: Paediatric
subject: Biliary Tract / Gallbladder
subject: Abdomen
subject: Transplantation

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To explore the definition of biliar atresia disease. To describe the radiological patterns of the disease. To present structural malformations associated to biliary atresia. To provide key points to the differential diagnosis. To propose a standard...
The neutron star in HESS J1731-347: CCOs as laboratories to study the equation of state of superdense matter
Creators: name: Klochkov, D.
name: Suleimanov, V.
name: Pühlhofer, G.
name: Yakovlev, D. G.
name: Santangelo, A.
name: Werner, K.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Context: Central Compact Objects (CCOs) in supernova remnants are isolated thermally emitting neutron stars (NSs). They are most probably characterized by a magnetic field strength that is roughly two orders of magnitude lower than that of most of the radio and accreting pulsars. The thermal emission of CCOs can be modeled to obtain constraints on the physical parameters of the star such as its mass, radius, effective temperature, and chemical composition. Aims: The CCO in HESS, J1731-347 is one of the brightest objects of this class. We present our analysis of two new XMM-Newton observations of the source which increase the total exposure time of the by a factor of five compared to the analyses presented before. Methods: We use our numerical spectral models for carbon and hydrogen atmospheres to fit the spectrum of the CCO. From our fits, we derive constraints on the physical parameters of the emitting star. We also use the new data to derive new upper limits on pulsations and to confirm the absence of a long-term variability. Results: The analysis shows that atmosphere spectral models are clearly preferred by the fit over the blackbody function. Under the assumption that the X-ray emission is uniformly produced by the entire star surface, hydrogen atmosphere models lead to uncomfortably large distances of the CCO, above 7-8 kpc. On the other hand, the carbon atmosphere model formally excludes distances above 5-6 kpc and is compatible with the source located in the Scutum-Crux (3 kpc) or Norma-Cygnus (4.5 kpc) Galactic spiral arm. We provide and discuss the corresponding confidence contours in the NS mass-radius plane. The measured effective temperature indicates that the NS is exceptionally hot for the estimated age of 30 kyr. We discuss possible cooling scenarios to explain this property, as well as possible additional constraints on the star mass and radius from cooling theory.
description: Accepted for publication in Astronomy & Astrophysics; a small error in the last section is corrected
Development of thermosensitive poloxamer 407-based microbubble gel with ultrasound mediation for inner ear drug delivery
Creators: name: Liao, Ai-Ho
name: Shih, Cheng-Ping
name: Li, Ming-Wei
name: Lin, Yi-Chun
name: Chuang, Ho-Chiao
name: Wang, Chih-Hung
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Our previous study first investigated feasibility of applying ultrasound (US) and microbubbles (MBs) via external auditory canal to facilitate drug delivery into inner ear. However, most drugs are in aqueous formulae and eliminated via Eustachian tubes after drug application. In this study, feasibility of sustained release of thermosensitive poloxamer 407 (P407)-based MB gel for US mediation-enhanced inner ear drug (dexamethasone, DEX) delivery was investigated. The sol-to-gel transition temperature showed that mixture of DEX and only 10% and 12.5% P407 in MBs can be used for in vitro and in vivo drug delivery experiments. In in vitro Franz diffusion experiments, the release rates of 12.5% P407-MBs + US groups in the model using DEX as the delivered reagent at 3 h resulted in values 1.52 times greater than those of 12.5% P407-MBs groups. In guinea pigs, by filling tympanic bulla with DEX in 12.5% P407-MBs (DEX-P407-MBs), USMB applied at post-treatment days 1 and 7 induced 109.13% and 66.67% increases in DEX delivery efficiencies, respectively, compared to the group without US. On the 28th day after US-mediated P407-MB treatment, the safety assessment showed no significant changes in the hearing thresholds and no damage to the integrity of cochlea or middle ear. These are the first results to demonstrate feasibility of US-modified liquid form DEX-P407-MB cavitation for enhancing permeability of round window membrane. Then, a gel form of DEX-P407-MBs was generated and thus prolonged the release of DEX in middle ear to maintain the therapeutic DEX level in inner ear for at least 7 days.
title: Pediatric elbow injuries - a pictorial review of radiological and surgical approach
Creators: name: Lanczi , Levente István
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Surgery
subject: Complications
subject: Conventional radiography
subject: Trauma
subject: Paediatric
subject: Musculoskeletal joint
subject: Acute
subject: Athletic injuries

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Elbow is a common site of trauma cases, while pediatric elbow fractures are challenging both for radiologists and pediatric surgeons: the joint’s anatomical complexity, the potential mechanism of injuries, the physiological and pathological bone...
Anti-inflammatory and antioxidant effects of nanoformulations composed of metal-organic frameworks delivering rutin and/or piperine natural agents
Creators: name: AbouAitah, Khaled
name: Higazy, Imane M.
name: Swiderska-Sroda, Anna
name: Abdelhameed, Reda M.
name: Gierlotka, Stanislaw
name: Mohamed, Tarik A.
name: Szałaj, Urszula
name: Lojkowski, Witold
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine

description: Plant-derived natural medicines have been extensively studied for anti-inflammatory or antioxidant properties, but challenges to their clinical use include low bioavailability, poor solubility in water, and difficult-to-control release kinetics. Nanomedicine may offer innovative solutions that can enhance the therapeutic activity and control release kinetics of these agents, opening the way to translating them into the clinic. Two agents of particular interest are rutin (Ru), a flavonoid, and piperine (Pip), an alkaloid, which exhibit a range of pharmacological activities that include antioxidant and anti-inflammatory effects. In this work, nanoformulations were developed consisting of two metal–organic frameworks (MOFs) with surface modifications, Ti-MOF and Zr-MOF, each of them loaded with Ru and/or Pip. Both MOFs and nanoformulations were characterized and evaluated in vivo for anti-inflammatory and antioxidant effects. Loadings of ∼17 wt.% for a single pro-drug and ∼27 wt.% for dual loading were achieved. The release patterns for Ru and or Pip followed two stages: a zero-order for the first 12-hour stage, and a second stage of stable sustained release. At pH 7.4, the release patterns best fit to zero-order and Korsmeyer–Peppas kinetic models. The nanoformulations had enhanced anti-inflammatory and antioxidant effects than any of their elements singly, and those with Ru or Pip alone showed stronger effects than those with both agents. Results of assays using a paw edema model, leukocyte migration, and plasma antioxidant capacity were in agreement. Our preliminary findings indicate that nanoformulations with these agents exert better anti-inflammatory and antioxidant effects than the agents in their free form.