cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 7 of Loss of the tumour suppressor LKB1/STK11 uncovers a leptin-mediated sensitivity mechanism to mitochondrial uncouplers for targeted cancer therapy
Creators: name: Angelopoulou, Andriani
name: Theocharous, Giorgos
name: Valakos, Dimitrios
name: Polyzou, Aikaterini
name: Magkouta, Sophia
name: Myrianthopoulos, Vassilios
name: Havaki, Sophia
name: Fiorillo, Marco
name: Tremi, Ioanna
name: Vachlas, Konstantinos
name: Nisotakis, Theodoros
name: Thanos, Dimitris-Foivos
name: Pantazaki, Anastasia
name: Kletsas, Dimitris
name: Bartek, Jiri
name: Petty, Russell
name: Thanos, Dimitris
name: McCrimmon, Rory J
name: Papaspyropoulos, Angelos
name: Gorgoulis, Vassilis G
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Additional file 7: Supplementary Fig. 2. Transcriptome analysis reveals Lkb1-regulated expression patterns. Transcriptome analysis of total RNA isolated from wt and lkb1 larvae at 5, 7 dpf and wt trunks at 11 dpf. Heatmap of (A) regulatory genes and (B) non-regulatory genes associated with key cellular processes. Data represents fold change of log2 rpm. (C) Piceatannol and Tyrphostin 23 treatment leads to significant upregulation of ucp2 expression. q-PCR for indicated marker mRNA levels in total RNA extracted from wt and lkb1 trunks at 6 dpf. Pgc1a does not show differential expression upon treatment. Pck1 is marginally upregulated in wt larvae upon treatment, while g6pca is downregulated in treated lkb1 larvae. Ucp2 is highly upregulated in both wt and lkb1 samples upon treatment. Data represent the means, ± standard errors of the means (SEM) and are pooled from three independent experiments. (D) q-PCR analysis of ucp2 in wild-type (wt) and lkb1 larvae during development. The maternal nutrient supply is depleted at 5 dpf. Ucp2 expression is increased in wt larvae only when they are under severe metabolic stress (after 8 dpf). In contrast, ucp2 is already expressed earlier and at much higher levels in the lkb1 mutants. Data represent the means, ± standard errors of the means (SEM) and are pooled from three independent experiments. *** P-value < 0.002, **** P-value < 0.0001; two-way ANOVA with Sidak’s multiple comparisons test. (E) Gene expression analysis of il6 and il1β in total RNA extracted from wt and lkb1 trunks at 7 dpf. Both genes were significantly upregulated in lkb1 samples. Data represent the means, ± standard errors of the means (SEM) and are pooled from three independent experiments. * P-value < 0.02; two-tailed student’s t-test. Dpf: days post fertilisation.
Where in the World are Canadian Oil and Gas Companies? 2012
Creators: name: Hojjati, Niloo
Publisher: name: The School of Public Policy Publications
Year: 2017

description: Begun in 2011 as an internal research tool for the development of the Extractive Resource Governance Program, this study seeks to answer the vital question: Where in the world are Canadian oil and gas companies? To answer this question, we extract firm-level information from publicly traded Canadian companies in order to establish the location of their activities around the globe.1 The data collected in the “Where in the World” (hereafter WIW) project are presented through a publicly accessible interactive world map, which allows users to explore a specific country or region over time. This map can be accessed online at http://www.policyschool.ca/research-teaching/teaching-training/extractiveresource-governance/ergp-map/. For background information regarding the WIW project, including an extensive overview of the methodology, please refer to  http://www.policyschool.ca/wp-content/uploads/2017/06/Where-in-the-WorldHojjati-Horsfield-Jordison-final.pdf. For a summarized overview of the annual data gathered in 2011, please refer to http://www.policyschool.ca/wp-content/ uploads/2017/06/2011-Where-in-the-World-Hojjati-Horsfield-Jordison-final.pdf. This report, as in the earlier report in this series, presents an extensive account of the global presence of Canadian oil and gas (hereafter O&G) companies in the 2012 year of study.2 In total, 228 Canadian O&G companies conducted operations in 85 countries in 2012, extending their presence to every region of the world. While North America continued to serve as the primary destination for Canadian exploration and production activities, the role of Canadian O&G service companies increased significantly in the Middle Eastern oil and gas industry, particularly in the United Arab Emirates, Saudi Arabia, Kuwait, and Oman. This report begins with a regional overview of the international activities of Canadian exploration and production (E&P) companies, followed by a summary of the level of activities on a country basis. The report then continues by providing the same analysis for Canadian O&G service companies.
description: The School of Public Policy Publications, Vol 10 (2017)
Where in the World are Canadian Oil and Gas Companies? 2013
Creators: name: Hojjati, Niloo
Publisher: name: The School of Public Policy Publications
Year: 2017

description: Begun in 2011 as an internal research tool for the development of the Extractive Resource Governance Program, this project seeks to answer the vital question: Where in the world are Canadian oil and gas companies? To answer this question, we extract firm-level information for publicly traded Canadian companies in order to establish the location of their activities around the globe.1 The data collected in the “Where in the World” (hereafter WIW) project are presented through a publicly accessible interactive world map, which allows users to explore a specific country or region over time. This map can be accessed online at http://www.policyschool.ca/research-teaching/teaching-training/ extractive-resource-governance/ergp-map/. For further information regarding the WIW project, including a comprehensive overview of the methodology, please refer to http://www.policyschool.ca/wp-content/uploads/2017/06/Where-in-theWorld-Hojjati-Horsfield-Jordison-final.pdf. In addition, summary reports of the annual data collection for the 2011 and 2012 years of analysis are also available at http://www.policyschool.ca/wp-content/uploads/2017/06/2011-Where-in-theWorld-Hojjati-Horsfield-Jordison-final.pdf and http://www.policyschool.ca/wpcontent/uploads/2017/06/2012-Where-in-the-World-Hojjati-final.pdf. This report, as in the earlier reports in this series, provides an account of emerging trends and highlights variations in the level of global activities of Canadian oil and gas companies (hereafter O&G) for the 2013 year of study.2 In 2013, a total of 226 Canadian O&G companies engaged in global exploration and service activities in 99 countries worldwide. The Middle East and Europe experienced the greatest increase in the concentration of Canadian exploration and production (E&P) companies. Meanwhile, the international presence of Canadian O&G service companies continued to grow in several countries, including Colombia, Mexico, and the United Kingdom. This report begins with a regional overview of the international presence of Canadian E&P companies, followed by a summary of country-level activities. The report then continues by providing the same analysis for Canadian O&G service companies.
description: The School of Public Policy Publications, Vol 10 (2017)
Additional file 8 of Loss of the tumour suppressor LKB1/STK11 uncovers a leptin-mediated sensitivity mechanism to mitochondrial uncouplers for targeted cancer therapy
Creators: name: Angelopoulou, Andriani
name: Theocharous, Giorgos
name: Valakos, Dimitrios
name: Polyzou, Aikaterini
name: Magkouta, Sophia
name: Myrianthopoulos, Vassilios
name: Havaki, Sophia
name: Fiorillo, Marco
name: Tremi, Ioanna
name: Vachlas, Konstantinos
name: Nisotakis, Theodoros
name: Thanos, Dimitris-Foivos
name: Pantazaki, Anastasia
name: Kletsas, Dimitris
name: Bartek, Jiri
name: Petty, Russell
name: Thanos, Dimitris
name: McCrimmon, Rory J
name: Papaspyropoulos, Angelos
name: Gorgoulis, Vassilis G
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Additional file 8: Supplementary Fig. 3. TP53KO/LKB1KO airway organoids exhibit features of lung adenocarcinoma in vitro and in vivo. (A-B) PCR amplification products of CRISPR/Cas9-mutated TP53 (A) or LKB1 (B) were obtained using primers flanking the targeted exons (exon 3 and 1, respectively). PCR products were subjected to TA cloning into a pGEM-T vector and subsequent sequencing revealed indels at the expected locations. For each sgRNA used, the targeted alleles are displayed. PAM sequences are underlined in red. In order to capture extensive genomic rearrangements the BLAT pairwise sequence alignment algorithm was used, whereas less extensive rearrangements are depicted using the sangerseq_viewer Python package. (C) Quantification of Ki67-positive cells in Fig. 1J demonstrating that TP53KO/LKB1KO organoids assume a highly proliferative phenotype, in accordance with their LUAD morphology. (D) TP53KO/LKB1KO organoids were orthotopically injected in the lungs of NOD-SCID mice (n ≥ 6). Stereoscopic lung tumour images, H&E, Thyroid Transcription Factor 1 (TTF-1) and human Keratin stainings verify successful engraftment of TP53KO/LKB1KO AO cells growing as LUADs following intratracheal injections. Scale: 20–100 μm. White arrows point to areas of tumour growth. (E) Successful engraftment and subsequent tumour growth was observed in ≥ 80% of mice injected with TP53KO/LKB1KO AOs. (F) q-PCR data displaying comparative mRNA levels of indicated genes in WT or CRISPR-Cas9-engineered TP53KO and TP53KO/LKB1KO AOs. Among the upregulated genes are markers of gluconeogenesis (PCK1, PPARGC1), the gluconeogenesis and cAMP responsive element modulator CREM, as well as established inflammation markers (IL6, IL1B). ***P < 0.001 and **P < 0.01, of Student’s t-test. Error bars indicate s.e.m. Data shown are representative of at least 3 independent experiments.
Additional file 9 of Loss of the tumour suppressor LKB1/STK11 uncovers a leptin-mediated sensitivity mechanism to mitochondrial uncouplers for targeted cancer therapy
Creators: name: Angelopoulou, Andriani
name: Theocharous, Giorgos
name: Valakos, Dimitrios
name: Polyzou, Aikaterini
name: Magkouta, Sophia
name: Myrianthopoulos, Vassilios
name: Havaki, Sophia
name: Fiorillo, Marco
name: Tremi, Ioanna
name: Vachlas, Konstantinos
name: Nisotakis, Theodoros
name: Thanos, Dimitris-Foivos
name: Pantazaki, Anastasia
name: Kletsas, Dimitris
name: Bartek, Jiri
name: Petty, Russell
name: Thanos, Dimitris
name: McCrimmon, Rory J
name: Papaspyropoulos, Angelos
name: Gorgoulis, Vassilis G
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Additional file 9: Supplementary Fig. 4. LEP is upregulated in TP53KO/LKB1KO and LKB1null LUAD organoids accompanied by enhanced sensitivity to identified metabolic activators. (A) LUAD AOs were generated after surgical resection of tumour tissue from LUAD patients and subsequently subjected to thorough genetic and histological characterisation. (B) Representative images of human LUAD organoids stained for haematoxylin and eosin (H&E) and Ki67. Two LKB1-proficient and one LKB1-null LUAD organoid lines were utilized (LKB1wt LUAD AO #1/#2 and LKB1null LUAD AO, respectively). Scale: 30 μm. (C) Western blotting from lysates of all LUAD AOs in (B) displaying upregulated LEP and UCP2 in LKB1null LUAD AOs. (D-E) Representative bright-field (BF) images and survival assessment of WT, LKB1wt or LKB1null LUAD organoid cultures receiving or not treatment with (D) tyrphostin 23 (60 µΜ) or (E) piceatannol for 5 days. Only LKB1null AOs die at the end of the treatment. Scale: 60 μm. (F-G) Immunohistochemistry on LKB1wt and LKB1null LUAD AOs to assess Ki67 levels upon treatment or not with (F) tyrphostin 23 or (G) piceatannol, at a less lethal dose (36 µΜ). LKB1null AOs display complete loss of proliferative capacity upon treatment. ***P < 0.001, of Student’s t-test. Error bars indicate s.e.m. N.s.; non-significant. Data shown are representative of at least 3 independent experiments.
Book Review
Heritage and Identity in Contemporary Thailand: Memory, Place and Power (2017) Reviewed by John Draper
Creators: name: Draper, John
Publisher: name: National Research Council of Thailand
Year: 2018
Subjects: Heritag, Identity, Contemporary Thailand, Memory, Place and Power (2017)

description: SOCIAL SCIENCE ASIA : Official Journal of National Research Council of Thailand in conjunction with the College of Local Administration Khon Kaen University, 4, 2, 86
America First: The Global Trump at Six Months
Creators: name: Robertson, Colin
Publisher: name: The School of Public Policy Publications
Year: 2017

description: For Donald Trump ‘America First’ means ‘America First.’ Canada and likeminded nations will have to get used to it. Canada will have to actively engage with Congress, the states and the private and public interests that drive the American agenda. We will also have to put more effort and contribute more to the rules-based order of which we have been a beneficiary. Traditional statecraft is based on predictability and stability, both hallmarks of U.S. post-war foreign policy practised by both Democrats and Republicans. Predictable, Mr. Trump is not. The deliberation and careful planning that characterized the Obama administration have been replaced by Mr. Trump’s reliance on gut and instinct. Such unpredictability will continue to create heartburn inside foreign chancelleries, whether friend or foe. Where once the USA was prepared to cover the spread on trade and security, under Donald Trump there will be more take than give. Now, Canada and the allies will have to make their own investments in hard power to preserve collective security. But less dependence and reliance on US leadership and more collective responsibility would be a good thing. Middle powers, like Canada, will have to step up their diplomacy, both collective and individual. Focusing on their own niche capacities they will have to shore up the space left by Trump Administration decisions on climate, migration and at the international institutions that sustain the rules-based order. Ironically, one effect of the Trump presidency may be to make the western alliance stronger.
description: The School of Public Policy Publications, Vol 10 (2017)
Susuacanga Martins 1997
Creators: name: Botero, Juan Pablo
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Susuacanga

description: Susuacanga Martins, 1997
Susuacanga Martins, 1997: 60; 1999: 134; Monné, 2005: 171.
Type-species: Cerambyx octoguttatus Germar, 1821 (original designation).
Redescription. Frons short, transverse. Antennal tubercles well-elevated, separated by coronal suture and a deep longitudinally sulcus on each side of suture. Superior lobes of eyes well-separated, distance between them at least twice the width of the upper lobe. Tuberculate between upper lobes (Fig. 1), sometimes the tubercle is barely elevated and divided by a suture; gula with transverse sulcus (Fig. 3). Antennae filiform, inner face of scape, pedicel, and at least antennomere III–IV with long erect hairs.
Prothorax with two lateral projections, an antemedian tubercle and one medially (sometimes reduced to an acute spine). Surface of prothorax, in both sexes, with deep, thick punctures (as Fig. 1), except S. falli (Fig. 7) and S. ulkei (Fig. 15), which have fine and shallow punctures or grooved with shallow rugosities. Pronotum with a transverse sulcus at anterior margin; a central elevation and two visible anterolateral tubercles. Mesosternal process lacking tubercle.
Elytra at least three times as long as broad, apices variable: unarmed, with an internal spine or with both margins spined. Apices of tibiae and femora spined or slightly projected.
Remarks. In the tribe Eburiini Blanchard, 1845 the presence of tubercle between the upper ocular lobes and the gula with a transverse sulcus is exclusive of the genera Susuacanga and Styliceps Lacordaire, 1869. Susuacanga differs from Styliceps by the pronotal surface with thick, deep punctures, or finely rugose, by the anterior margin of pronotum with no more than one transverse sulcus, and by the mesosternal process without a tubercle. In Styliceps the pronotal surface is very rugose (Fig. 2), the anterior margin of pronotum has two transverse sulcus (Fig. 2) and the mesosternal process has a tubercle. Besides the characteristics shared with Styliceps, Susuacanga differs from Eburia by its deeply punctured pronotal surface which is never present in Eburia.
description: Published as part of Botero, Juan Pablo, 2014, Review of the genus Susuacanga (Coleoptera, Cerambycidae, Cerambycinae), pp. 518-528 in Zootaxa 3779 (5) on page 519, DOI: 10.11646/zootaxa.3779.5.2, http://zenodo.org/record/227695
Additional file 10 of Loss of the tumour suppressor LKB1/STK11 uncovers a leptin-mediated sensitivity mechanism to mitochondrial uncouplers for targeted cancer therapy
Creators: name: Angelopoulou, Andriani
name: Theocharous, Giorgos
name: Valakos, Dimitrios
name: Polyzou, Aikaterini
name: Magkouta, Sophia
name: Myrianthopoulos, Vassilios
name: Havaki, Sophia
name: Fiorillo, Marco
name: Tremi, Ioanna
name: Vachlas, Konstantinos
name: Nisotakis, Theodoros
name: Thanos, Dimitris-Foivos
name: Pantazaki, Anastasia
name: Kletsas, Dimitris
name: Bartek, Jiri
name: Petty, Russell
name: Thanos, Dimitris
name: McCrimmon, Rory J
name: Papaspyropoulos, Angelos
name: Gorgoulis, Vassilis G
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Additional file 10: Supplementary Fig. 5. Treatment of LKB1null LUAD organoids with metabolic stressors induces senescence. (A) Gating parameters on LKB1wt and LKB1null samples for FACS experiments. (B) FACS plots and quantification of the percentage of senescent cells upon treatment of LKB1wt or LKB1null LUAD organoids with piceatannol or tyrphostin 23 at sublethal concentrations (36 µM) versus untreated counterparts. Senescence was assessed by implementing the rapid senescence detection fluorophore-conjugated GLF16 compound [10]. Treatment of organoids with either metabolic stressors led to significant induction of senescence compared to control only in LKB1-null conditions. (C) FACS plots and relevant quantification confirming that combined use of senolytics dasatinib and quercetin (D + Q) on LKB1null LUAD organoids receiving treatment with piceatannol or tyrphostin 23 significantly eradicates senescent cell populations. Piceatannol/tyrphostin 23-mediated growth arrest is achieved even at low concentrations, via senescence induction. (D) mRNA levels of gluconeogenesis genes in LKB1wt and LKB1null AOs. The gluconeogenesis regulator PDK2 is found dramatically increased in the absence of LKB1. ***P < 0.001 and **P < 0.01, of Student’s t-test. Error bars indicate s.e.m. N.s.; non-significant. Data shown are representative of at least 3 independent experiments.
title: Geschichtsklitterungen – Zäsuren – Neuverhandlungen
Creators: name: Markova, Ina
Year: 2010

description: Diese Diplomarbeit folgt einem historisch-politisch orientierten Gedächtnisbegriff. Zentrale Frage ist dabei: Welcher Vergangenheitsentwurf über den Nationalsozialismus ist zu einer bestimmten Zeit wirksam, wie, wann und warum lassen sich Transformationen feststellen? Im Fokus der diachronen Untersuchung standen visuelle und sprachliche Strategien, mit welchen im nationalen Erinnerungsmedium Schulbuch von etwa 1945 bis heute kollektiv geteiltes Wissen über die österreichische Vergangenheit zwischen 1934 und 1955 dargestellt wird. Der Fokus dieser Arbeit ist die Untersuchung der Erinnerungsleistung von Bildern: Dies führt zu einer Analyse der Zusammenhänge zwischen Bildern, Diskursen, Macht und Wissen, da sowohl sprachliche Aussagen als auch „geschichtsmächtige“ Bilder das Feld des Darstellbaren einer Gemeinschaft aufspannen. Als zentrale Zäsur der österreichischen Erinnerung an den Holocaust können im gesamtgesellschaftlichen Rahmen die Waldheim-Affäre 1986, und auf curricularer Ebene die neuen AHS/HS-Lehrpläne von 1989/85 festgestellt werden. Das nationale Narrativ über die österreichische Vergangenheit kann lange Zeit als stabiler Block gefasst, als wichtigster narrativer Baustein die österreichische „Opferthese“ benannt werden. Zentral für dieses Geschichtsbild ist die visuelle Ikone der Unterzeichnung des Staatsvertrags. In der zweiten Hälfte der 1980er Jahre bekam dieses „geschichtsmächtige Bild“ Konkurrenz von seinem Gegenpart, der kritischen Ikone der potenziellen Mitverantwortung an NS-Verbrechen: dabei handelt es sich um das Bild der jubelnden Wiener Bevölkerung während Hitlers Heldenplatzansprache. Es kann von einer „partiellen Erosion“ der Opferthese gesprochen werden: Ab etwa 1986 gestalten sich österreichische Erinnerungen an Nationalsozialismus, Holocaust und Zweitem Weltkrieg als ein Produkt von Positionierungen innerhalb eines Koordinatensystems zwischen den beiden Achsen „Mitverantwortung“ und „Opferthese“.
Additional file 11 of Loss of the tumour suppressor LKB1/STK11 uncovers a leptin-mediated sensitivity mechanism to mitochondrial uncouplers for targeted cancer therapy
Creators: name: Angelopoulou, Andriani
name: Theocharous, Giorgos
name: Valakos, Dimitrios
name: Polyzou, Aikaterini
name: Magkouta, Sophia
name: Myrianthopoulos, Vassilios
name: Havaki, Sophia
name: Fiorillo, Marco
name: Tremi, Ioanna
name: Vachlas, Konstantinos
name: Nisotakis, Theodoros
name: Thanos, Dimitris-Foivos
name: Pantazaki, Anastasia
name: Kletsas, Dimitris
name: Bartek, Jiri
name: Petty, Russell
name: Thanos, Dimitris
name: McCrimmon, Rory J
name: Papaspyropoulos, Angelos
name: Gorgoulis, Vassilis G
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Additional file 11: Supplementary Fig. 6. LKB1 deficiency is accompanied by a deregulated mitochondrial and bioenergetic profile exacerbated by piceatannol or tyrphostin 23 treatment. (A) Transmission electron microscopy (TEM) pictures of indicated organoid lines before and after treatment with piceatannol or tyrphostin 23 (36 µM). WT AOs were used as reference for normal mitochondrial structure, indicated with single black arrow. Most cells of LKB1wt LUAD AOs displayed normal mitochondria, with or without treatment. Most cells of LKB1null LUAD AOs exhibited aberrant mitochondrial structure, further deteriorated upon piceatannol or tyrphostin 23 treatment. Double black arrows indicate aberrant mitochondrial morphology, such as partial loss of cristae, cristae widening and mitochondrial elongation. N: nucleus; Scale bar: 1000 nm. (B) Oxygen Consumption Rate (OCR) of indicated untreated or piceatannol/tyrphostin 23-treated cells was determined using the Seahorse XFe96, via metabolic flux analysis. LKB1null LUAD cells display a decrease in both basal and maximal respiration, as well as mitochondrial ATP production, compared to LKB1wt LUAD counterparts, and the effect is exacerbated upon compound treatment. (C) Extracellular Acidification Rate (ECAR) of indicated untreated or piceatannol/tyrphostin 23-treated cells was determined as in (B). LKB1null LUAD cells show a decrease in glycolytic reserve, which is further reduced upon compound treatment. Data represent the % average ± SD over LKB1wt LUAD cells, n = 3. Two-way ANOVA, ns = not significant, *P < 0.05, **P < 0.005, ***P < 0.0005, ****P < 0.00005.
Enforcement Issues Associated with Prospectus Exemptions in Canada
Creators: name: MacIntosh, Jeffrey G.
Publisher: name: The School of Public Policy Publications
Year: 2017

description: This paper examines the regime of prospectus exemptions in Canada. The focus is on the enforcement process, and to this end the article includes an empirical examination of enforcement actions by both the securities regulators and the Investment Industry Regulatory Organization of Canada (IIROC). The end in view is two-fold; to provide a description of the exempt market and enforcement efforts, and to comment on whether enforcement resources are properly deployed. The latter necessarily requires a critical examination of the nature of the various exemptions, their purposes, and whether they are appropriately crafted to achieve their desired ends. That in turn requires an analysis of which issuers use the various exemptions, what types of securities are issued, and who the buyers are. Unfortunately, the Canadian data falls far short of painting a comprehensive or reliable picture of the exempt market. This is a product of many factors. Notably, many exempt financings need not be reported to the regulators. Moreover, many small private companies do not report their exempt financings even when required to do so. The extent of the under-reporting problem (from both causes) is illustrated by data from Statistics Canada suggesting that in 2014, there were about 156,000 exempt financings across Canada. However, in that year, only about 7,125 exempt financing reports were filed with the regulators. Understanding the nature of the exempt market is also hindered by the fact that not all of the provincial regulators compile statistics relating to the use of the various exemptions, and even among regulators that provide statistics, these are not published on an annual basis. Added to this, the published statistics that we have fall far short of painting a comprehensive or picture of the exempt market. The regulators do not compile cross-tabulated statistics relating to the nature of the issuers, the types of purchasers, the amount of capital raised, and the types of securities issued. Nor do they keep statistics on redemptions of prospectus-exempt securities, thus potentially yielding a material overstatement of the net amount of prospectus exempt financings each year.
description: The School of Public Policy Publications, Vol 10 (2017)
Susuacanga blancaneaui Bates 1880, comb. nov.
Creators: name: Botero, Juan Pablo
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Susuacanga
Susuacanga blancaneaui

description: Susuacanga blancaneaui (Bates, 1880) comb. nov.
(Fig. 4–6)
Eburia blancaneaui Bates, 1880: 20; Monné, 2005: 142; Hovore, 2006: 371. Eburia blancaneauxi; Bates, 1884: pl. 17, fig. 5 (error).
Geographical distribution. Mexico (Oaxaca, Chiapas), Guatemala, Belize, Honduras, El Salvador.
Type material examined. Holotype, BELIZE, Toledo: River Sarstoon, male (BMNH).
Specimens examined. No locality label, female (USNM); MEXICO, Oaxaca: Santiago Xiacui (2030 m), female, VI.2006. D. Curoe leg. (MNRJ). PERU, Loreto: Iquitos, male (USNM).
Comments. Susuacanga blancaneaui is recorded from Mexico, Guatemala, Belize, Honduras and El Salvador. A specimen was found labeled as from Loreto, Peru. This is doubtful. Additional specimens are needed from this area to confirm the records validity.
description: Published as part of Botero, Juan Pablo, 2014, Review of the genus Susuacanga (Coleoptera, Cerambycidae, Cerambycinae), pp. 518-528 in Zootaxa 3779 (5) on page 520, DOI: 10.11646/zootaxa.3779.5.2, http://zenodo.org/record/227695
title: Die Thematisierung des Islam durch die Schweizerische Volkspartei am Beispiel der Volksinitiative "Gegen den Bau von Minaretten"
Creators: name: Kassal, Michael
Year: 2010

description: Die vorliegende Diplomarbeit untersucht die Darstellung des Islam durch die Schweizerische Volkspartei in ihrer Kampagne für ein Verbot des Baus von Minaretten. In einem weiteren Schritt wird der Zusammenhang des Islamdiskurs mit dem Asyl- und Ausländerdiskurs der Partei analysiert.
New extended interpolating fields built from three-dimensional fermions
Creators: name: Papinutto, Mauro
name: Scardino, Francesco
name: Schaefer, Stefan
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2018
Subjects: dimension: 3
flavor: 3
short-distance behavior
lattice field theory
two-point function
continuum limit
renormalization
quenching
overlap

description: New extended interpolating operators made of quenched three dimensional fermions are introduced in the context of lattice QCD. The mass of the 3D fermions can be tuned in a controlled way to find a better overlap of the extended operators with the states of interest. The extended operators have good renormalization properties and are easy to control when taking the continuum limit. Moreover the short distance behaviour of the two point functions built from these operators is greatly improved. A numerical comparison with point sources and Jacobi smeared sources on dynamical 2+1 flavour configurations is presented.
The spectrum of 2+1 dimensional Yang-Mills theory on a twisted spatial torus
Creators: name: García Pérez, Margarita
name: González-Arroyo, Antonio
name: Koren, Mateusz
name: Okawa, Masanori
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2018
Subjects: subject: 530
subject: gauge field theory: SU(N)
subject: boundary condition: twist
subject: flux: magnetic
subject: space-time: dimension: 3
subject: nonperturbative
subject: glueball
subject: torelon
subject: lattice
subject: expansion 1/N

description: We compute and analyse the low-lying spectrum of 2+1 dimensional SU(N) Yang-Mills theory on a spatial torus of size l × l with twisted boundary conditions. This paper extends our previous work [1]. In that paper we studied the sector with non-vanishing electric flux and concluded that the energies only depend on the parameters through two combinations: x = λN l/(4π) (with λ the ’t Hooft coupling) and the twist angle $ \tilde{\theta} $ defined in terms of the magnetic flux piercing the two-dimensional box. Here we made a more complete study and we are able to condense our results, obtained by non-perturbative lattice methods, into a simple expression which has important implications for the absence of tachyonic instabilities, volume independence and non-commutative field theory. Then we extend our study to the sector of vanishing electric flux. We conclude that the onset of the would-be large-volume glueball states occurs at an approximately fixed value of x, much before the stringy torelon states have become very massive.
Additional file 12 of Loss of the tumour suppressor LKB1/STK11 uncovers a leptin-mediated sensitivity mechanism to mitochondrial uncouplers for targeted cancer therapy
Creators: name: Angelopoulou, Andriani
name: Theocharous, Giorgos
name: Valakos, Dimitrios
name: Polyzou, Aikaterini
name: Magkouta, Sophia
name: Myrianthopoulos, Vassilios
name: Havaki, Sophia
name: Fiorillo, Marco
name: Tremi, Ioanna
name: Vachlas, Konstantinos
name: Nisotakis, Theodoros
name: Thanos, Dimitris-Foivos
name: Pantazaki, Anastasia
name: Kletsas, Dimitris
name: Bartek, Jiri
name: Petty, Russell
name: Thanos, Dimitris
name: McCrimmon, Rory J
name: Papaspyropoulos, Angelos
name: Gorgoulis, Vassilis G
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Additional file 12: Supplementary Fig. 7. LKB1-dependent changes in transcription factor levels identified as potential regulators of the LEP gene. (A) STRING network representing the functional relationship between LKB1 and the potentially LEP-regulating transcription factors identified in Fig. 1M. (B) q-PCRs of indicated genes in CRISPR/Cas9-engineered AOs displaying either non-significant changes between conditions (WT, p53KO, p53KO/LKB1KO AOs) or expression changes likely not attributed to LKB1 alone. (C) Western blotting and q-PCR for indicated markers in LKB1wt and LKB1null LUAD AOs. Western blotting differences are verified among multiple independent experiments (n ≥ 5). (D) Densitometry for Western blotting in Fig. 1P. (E) Quantification of ubiquitination levels across different conditions in Fig. 2B. (F) Schematic depicting the identified LKB1-dependent regulation of LEP via HIF1A, in LKB1-proficient and -deficient LUADs. In the presence of LKB1, low expression of HIF1A results in lack of HIF1A-mediated activation of LEP transcription, with a considerable impact on overall LEP levels. In contrast, upon loss of LKB1, upregulation of HIF1A leads to high-affinity LEP promoter occupancy by HIF1A, resulting in significantly increased LEP levels. Additional treatment with piceatannol or tyrphostin 23 further stabilises HIF1A via inhibition of VHL-mediated HIF1A ubiquitination, resulting in hyperactivation of LEP. ***P < 0.001, of Student’s t-test. Error bars indicate s.e.m. N.s.; non-significant. Data shown are representative of at least 3 independent experiments.
Susuacanga falli Linsley 1940
Creators: name: Botero, Juan Pablo
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Susuacanga
Susuacanga falli

description: Susuacanga falli (Linsley, 1940)
(Fig. 7)
Eburia falli Linsley, 1940: 257; Monné, 2005: 145. Susuacanga falli; Tavakilian, 2013: 109
Eburia semipubescens; Fall, 1909: 163 (not Thomson, 1861).
Geographical distribution. United States (Arizona, southern California), Mexico (Baja California, Sinaloa, Sonora).
Specimens examined. UNITED STATES, Arizona: Pima, female, VII.1973 (USNM); male, VII.1974 (USNM); 2 females, VII.1975 (USNM); female, VII.1978 (USNM); male and female, VII.1981 (USNM); (14.2 mi. S. Three Points), female, 10–11.VIII.1974, J.M. Cicero leg (MNRJ); Rio Rico (Sta, Cruz Co.), 2 females, VII.1974 (USNM); California: Imperial County (1.5 mi N. Glamis), female, IX.1973 (USNM); male, IX,1980 (USNM); male, 29.VIII.1989 (MNRJ). MEXICO, Sinaloa: San Blas, female, VII.1974 (MNRJ).
description: Published as part of Botero, Juan Pablo, 2014, Review of the genus Susuacanga (Coleoptera, Cerambycidae, Cerambycinae), pp. 518-528 in Zootaxa 3779 (5) on pages 520-522, DOI: 10.11646/zootaxa.3779.5.2, http://zenodo.org/record/227695
Additional file 13 of Loss of the tumour suppressor LKB1/STK11 uncovers a leptin-mediated sensitivity mechanism to mitochondrial uncouplers for targeted cancer therapy
Creators: name: Angelopoulou, Andriani
name: Theocharous, Giorgos
name: Valakos, Dimitrios
name: Polyzou, Aikaterini
name: Magkouta, Sophia
name: Myrianthopoulos, Vassilios
name: Havaki, Sophia
name: Fiorillo, Marco
name: Tremi, Ioanna
name: Vachlas, Konstantinos
name: Nisotakis, Theodoros
name: Thanos, Dimitris-Foivos
name: Pantazaki, Anastasia
name: Kletsas, Dimitris
name: Bartek, Jiri
name: Petty, Russell
name: Thanos, Dimitris
name: McCrimmon, Rory J
name: Papaspyropoulos, Angelos
name: Gorgoulis, Vassilis G
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Additional file 13: Supplementary Fig. 8. Sequencing results verifying successful LEP KO in LKB1null LUAD organoids. (A-B) PCR amplification products of the mutated alleles were obtained using primers flanking the targeted exons. PCR products were subjected to TA cloning into a pGEM-T vector and subsequent sequencing revealed indels at the expected locations. For each sgRNA used, the WT sequences and the targeted alleles are displayed. PAM sequences are underlined in red. In order to capture extensive genomic rearrangements the BLAT pairwise sequence alignment algorithm was used, whereas less extensive rearrangements are depicted using the sangerseq_viewer Python package. When the BLAT algorithm is used, nucleotides marked in blue are successfully aligned between WT and mutant alleles, whereas lower case nucleotides in black indicate the introduction of an indel.
Susuacanga hatsueae Chemsak & Giesbert 1986
Creators: name: Botero, Juan Pablo
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Susuacanga
Susuacanga hatsueae

description: Susuacanga hatsueae (Chemsak & Giesbert, 1986)
(Fig. 8)
Eburia hatsueae Chemsak & Giesbert, 1986: 21; Monné, 2005:146. Susuacanga hatsueae; Tavakilian, 2013: 109
Geographical distribution. Mexico (Jalisco, Michoacán, Guerrero, Oaxaca).
Specimens examined. MEXICO, Jalisco: Chamela (via UNAM), male, 9–19.VII.1993, J.E. Wappes leg. (MNRJ); male and 3 females, 9–19.VII.1993, J.E. Wappes leg. (USNM); Oaxaca: (Hwy. 190, 5,3 km N. Totolapan), male, 2.VII.1992, G.H. Nelson Leg. (USNM).
description: Published as part of Botero, Juan Pablo, 2014, Review of the genus Susuacanga (Coleoptera, Cerambycidae, Cerambycinae), pp. 518-528 in Zootaxa 3779 (5) on page 522, DOI: 10.11646/zootaxa.3779.5.2, http://zenodo.org/record/227695
Experiences From I/O Point Of View: Weather & Climate
Creators: name: Narasimhamurthy, Sai
Publisher: name: Zenodo
Year: 2018

description: Session: ESiWACE: What is special about HPC computing for weather and climate?

Event Type: Birds of a Feather

Day: 26 June 2018

Location: ISC2018, Frankfurt (DE)

Time: 08:30-09:30

Room: Kontrast

* Title of the workshop: What makes climate computing special?

* Short description of the event: BOF session at ISC 2018

* info on target audience: scientific community

* draft agenda: as an attachment here below

* invited speakers

* Organisers: Reinhard Budich and Oliver Perks
description: ESiWACE has received funding from the European Union's Horizon 2020 Research and Innovation Programme under Grant Agreement No 675191
Susuacanga maculicornis Bates 1870
Creators: name: Botero, Juan Pablo
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Susuacanga
Susuacanga maculicornis

description: Susuacanga maculicornis (Bates, 1870)
(Fig. 9)
Eburia maculicornis Bates, 1870: 266.
Eburia octoguttata ab. melanescens Tippmann, 1960: 115.
Susuacanga maculicornis; Martins, 1997: 60; Monné, 2005: 171; Monné et al., 2010: 239.
Geographical distribution. Brazil (Bahia to Santa Catarina).
Specimens examined. BRAZIL, Bahia: Barreiras, male, XII.1991, B. Silva leg. (MNRJ); Minas Gerais: Manhuaçu, female, XI.1972. C.A.C. Seabra leg. (MNRJ); Espirito Santo: Vargem Alta, male, XI.1938, A. Maller leg. (MNRJ); São Paulo: Faxina, male, II.1938, F. Tippman leg. (paratype of Eburia octoguttata ab. melanescens Tippmann, 1960) (USNM); Santa Catarina, male and female, I.1931, F. Tippmann leg. (USNM); Boutuverá (Tijuco preto), male, 1940, A. Maller leg. (MNRJ); São Bento, female, II.1938, A. Maller leg. (MNRJ); Corupá, female, XII.1936, A. Maller leg. (MNRJ); male, I.1954, A. Maller leg. (MNRJ).
description: Published as part of Botero, Juan Pablo, 2014, Review of the genus Susuacanga (Coleoptera, Cerambycidae, Cerambycinae), pp. 518-528 in Zootaxa 3779 (5) on page 522, DOI: 10.11646/zootaxa.3779.5.2, http://zenodo.org/record/227695
Additional file 14 of Loss of the tumour suppressor LKB1/STK11 uncovers a leptin-mediated sensitivity mechanism to mitochondrial uncouplers for targeted cancer therapy
Creators: name: Angelopoulou, Andriani
name: Theocharous, Giorgos
name: Valakos, Dimitrios
name: Polyzou, Aikaterini
name: Magkouta, Sophia
name: Myrianthopoulos, Vassilios
name: Havaki, Sophia
name: Fiorillo, Marco
name: Tremi, Ioanna
name: Vachlas, Konstantinos
name: Nisotakis, Theodoros
name: Thanos, Dimitris-Foivos
name: Pantazaki, Anastasia
name: Kletsas, Dimitris
name: Bartek, Jiri
name: Petty, Russell
name: Thanos, Dimitris
name: McCrimmon, Rory J
name: Papaspyropoulos, Angelos
name: Gorgoulis, Vassilis G
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Additional file 14: Supplementary Fig. 9. Sequencing results verifying successful UCP2 KO in LKB1null LUAD organoids. (A-B) PCR amplification products of the mutated alleles were obtained using primers flanking the targeted exons. PCR products were subjected to TA cloning into a pGEM-T vector and subsequent sequencing revealed indels at the expected locations. For each sgRNA used, the WT sequences and the targeted alleles are displayed. PAM sequences are underlined in red. In order to capture extensive genomic rearrangements the BLAT pairwise sequence alignment algorithm was used, whereas less extensive rearrangements are depicted using the sangerseq_viewer Python package. When the BLAT algorithm is used, nucleotides marked in blue are successfully aligned between WT and mutant alleles, whereas lower case nucleotides in black indicate the introduction of an indel. (C) Representative bright-field (BF) images and Ki67 stainings of the indicated AO lines receiving or not treatment with piceatannol or tyrphostin 23 for 5 days. See also Fig. 2G for respective quantification Scale: 30–60 μm.
title: Fachkräfte in Einrichtungen der Behindertenhilfe im Spannungsfeld zwischen Selbstbestimmung und Pädagogik
Creators: name: Birkner, Katharina
Year: 2010

description: Die vorliegende Arbeit befasst sich mit der Begriffsbestimmung, dem Empowerment-Konzept und der damit verbundenen Selbstbestimmung von Menschen mit Behinderung. Hierbei spielen vor allem die Fachkräfte in Einrichtungen der Behindertenhilfe eine Rolle, der Wandel in ihren Aufgaben in den letzten Jahren, und die sich daraus ergebenden Konsequenzen für den beruflichen Alltag. Der Schwerpunkt liegt auf der Analyse der Ausgaben von sieben führenden deutschsprachigen sonderpädagogischen Fachzeitschriften im Zeitraum von 1994 bis 2009. Es soll herausgefunden werden, ob eine Thematisierung des Spannungsfeldes, in dem sich Fachkräfte in Einrichtungen der Behindertenhilfe befinden, stattfindet. Dies soll anhand der hermeneutischen Literaturanalyse und der quantitativen Inhaltsanalyse ermittelt werden. Nach einem Splitting der Spannungsfelder ist das Kernergebnis der Analyse, dass die oben beschriebene Fragestellung in ausgewählten sonderpädagogischen Fachzeitschriften sehr wohl ein Thema ist und von den Autoren bearbeitet wird.
description: The topic of the paper is concerned with the concept of empowerment and its connection to the term self-determination of people with disabilities. Important are the skilled employees in facilities for challenged people, the changes of their functions over the last few years and the work related consequences resulting from this change. The focus of this paper lies upon the analysis of the issues of seven leading german special-educational magazines in the period from 1994 to 2009. The aim is to find out, if the areas of conflict, which the skilled employees have to deal with, are commented on sufficiently. This should be determined using the hermeneutical literature analysis and the quantitative content analysis. After a splitting of the areas of conflict into several categories, the main result of the analysis is that the research question mentioned above actually is approached and dealt with by the authors of the magazines.
title: Es lebe Gott allein in mir
Creators: name: Gemeinde der Hutterer von Fairholme
Publisher: name: Universitätsverlag Wagner
Year: 2022
Subjects: subject: FOS: Arts (arts, history of arts, performing arts, music)
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Tonbeispiel 4, 3 Strophen.
Verfasser: Gerhard Tersteegen.
Aus dem Gesangbuch: Gesangsbüchlein 2017, Nr. 155.
Mitwirkende: gesamte Gemeinde (ca. 65 Personen).
Aufnahme: Judith Rubatscher.
Ort: Fairholme Colony, Essensstube.
Kontext: Singen am Sonntagsnachmittag.
Aufnahmedatum: 02.09.2019.
Dauer: 01:56 Minuten.

description: Die Auswahl der Tonbeispiele wurde gemeinsam mit den Bewohner*innen von Fairholme getroffen. Es handelt sich dabei großteils um Lieder, die in der Kolonie häufig und gerne gesungen werden. Sie sind exemplarisch für den Klang des gemeinschaftlichen Singens, an dem die gesamte Gemeinde beteiligt ist. Allerdings stellen die Tonbeispiele keinen repräsentativen Querschnitt durch die zahlreichen, im Buch: "´Singen is Part vo unsam Lebm.´Musik bei den Hutterern von Fairholme/Manitoba" dargestellten Singanlässe dar.
Book Review
Strangers in their Own Land: Anger and Mourning on the American Right (2016) Reviewed by Narut Wasinpiyamongkhon
Creators: name: Narut Wasinpiyamongkhon
Publisher: name: National Research Council of Thailand
Year: 2018
Subjects: Strangers, Own Land, Anger, Mourning, American Right, 2016

description: SOCIAL SCIENCE ASIA : Official Journal of National Research Council of Thailand in conjunction with the College of Local Administration Khon Kaen University, 4, 2, 91
Additional file 15 of Loss of the tumour suppressor LKB1/STK11 uncovers a leptin-mediated sensitivity mechanism to mitochondrial uncouplers for targeted cancer therapy
Creators: name: Angelopoulou, Andriani
name: Theocharous, Giorgos
name: Valakos, Dimitrios
name: Polyzou, Aikaterini
name: Magkouta, Sophia
name: Myrianthopoulos, Vassilios
name: Havaki, Sophia
name: Fiorillo, Marco
name: Tremi, Ioanna
name: Vachlas, Konstantinos
name: Nisotakis, Theodoros
name: Thanos, Dimitris-Foivos
name: Pantazaki, Anastasia
name: Kletsas, Dimitris
name: Bartek, Jiri
name: Petty, Russell
name: Thanos, Dimitris
name: McCrimmon, Rory J
name: Papaspyropoulos, Angelos
name: Gorgoulis, Vassilis G
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Additional file 15: Supplementary Fig. 10. Piceatannol and Tyrphostin 23 exclusively suppress transplanted LKB1-deficient human LUAD organoids in vivo. GLF16 immunofluorescence in untreated, piceatannol- or tyrphostin 23-treated LKB1wt and LKB1null mouse xenografts. Treatment with either compound induces in vivo senescence only in LKB1null mouse xenografts. Scale: 30 μm. Quantification is presented in Fig. 2M.