cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
STRUCTURED PREDICTION: STATISTICAL AND COMPUTATIONAL GUARANTEES IN LEARNING AND INFERENCE
Creators: name: Medina, Kevin Segundo Bello
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Knowledge representation and reasoning

description: Structured prediction consists of receiving a structured input and producing a combinatorial structure such as trees, clusters, networks, sequences, permutations, among others. From the computational viewpoint, structured prediction is in general considered intractable because of the size of the output space being exponential in the input size. For instance, in image segmentation tasks, the number of admissible segments is exponential in the number of pixels. A second factor is the combination of the input dimensionality along with the amount of data under availability. In structured prediction it is common to have the input live in a high-dimensional space, which involves to jointly reason about thousands or millions of variables, and at the same time contend with limited amount of data. Thus, learning and inference methods with strong computational and statistical guarantees are desired. The focus of our research is then to propose principled methods for structured prediction that are both polynomial time, i.e., computationally efficient, and require a polynomial number of data samples, i.e., statistically efficient.
The main contributions of this thesis are as follows:
(i) We develop an efficient and principled learning method of latent variable models for structured prediction under Gaussian perturbations. We derive a Rademacher-based generalization bound and argue that the use of non-convex formulations in learning latent-variable models leads to tighter bounds of the Gibbs decoder distortion.
(ii) We study the fundamental limits of structured prediction, i.e., we characterize the necessary sample complexity for learning factor graph models in the context of structured prediction. In particular, we show that the finiteness of our novel MaxPair-dimension is necessary for learning. Lastly, we show a connection between the MaxPair-dimension and the VC-dimension---which allows for using existing results on VC-dimension to calculate the MaxPair-dimension.
(iii) We analyze a generative model based on connected graphs, and find the structural conditions of the graph that allow for the exact recovery of the node labels. In particular, we show that exact recovery is realizable in polynomial time for a large class of graphs. Our analysis is based on convex relaxations, where we thoroughly analyze a semidefinite program and a degree-4 sum-of-squares program. Finally, we extend this model to consider linear constraints (e.g., fairness), and formally explain the effect of the added constraints on the probability of exact recovery.
D3.2 Bigdataocean Harmonisation, Knowledge Extraction, Business Intelligence And Usage Analytics Services
Creators: name: Project Consortium Members
Publisher: name: Zenodo
Year: 2017

description: In the context of this deliverable, the first version of the various BigDataOcean services related to harmonisation, knowledge extraction, business intelligence and usage analytics service is reported.
description: Disclaimer: The BigDataOcean project is co-funded by the Horizon 2020 Programme of the European Union. This document reflects only authors' views. The EC is not liable for any use that may be done of the information contained therein
Additional file 2 of Metabolic syndrome biomarkers relate to rate of cognitive decline in MCI and dementia stages of Alzheimer’s disease
Creators: name: Pillai, Jagan A.
name: Bena, James
name: Bekris, Lynn
name: Kodur, Nandan
name: Kasumov, Takhar
name: Leverenz, James B.
name: Kashyap, Sangeeta R.
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health

description: Additional file 2: Supplementary Table 1. Associations between TG/HDL, APOA1 and AD and inflammatory biomarkers in MCI patients
Development of a Closed-Loop, Implantable Electroceutical Device for Glaucoma
Creators: name: Shah, Jay V
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Medical devices
Electrical engineering not elsewhere classified
Biomedical instrumentation

description: Glaucoma is the leading cause of irreversible blindness worldwide. While current therapies aim to lower elevated intraocular pressure (IOP) to prevent blindness, they often do not provide the desired long-term efficacy, can fail over time, and have systemic side effects. Electroceutical stimulation can be a solution to many of these current issues with glaucoma treatment, as it is believed to have fewer systemic side effects and quicker response times. The goal of this work is to develop and demonstrate a novel system using electrical stimulation to lower intraocular pressure. I present data from a human clinical study and an ongoing clinical trial of the IOPTx™ system, a wearable electroceutical for treating glaucoma, that provides preliminary evidence of efficacy and safety. Furthermore, no current glaucoma treatments allow for closed-loop, continuous monitoring of IOP, requiring more frequent doctor visits or forcing patients and clinicians to operate in the dark. Using an electroceutical therapeutic device with closed-loop feedback and continuous IOP recording can improve glaucoma management. I combined a pressure sensor with this electroceutical therapy, implanted the sensor and stimulation coils in rabbits, and stimulated the eyes. However, to better understand the optimal stimulation parameters, long-term effects, and mechanisms of action, an integrated circuit is designed as part of a fully implantable, closed-loop device. The chip was fabricated in 0.18 µm CMOS process and validated on the benchtop and in vivo. In the future, this electroceutical device has the potential to be a novel treatment for patients suffering from glaucoma.
sj-doc-2-tab-10.1177_1759720X211037530 – Supplemental material for Comparative effectiveness of treatment options for subacromial shoulder conditions: a systematic review and network meta-analysis
Creators: name: Babatunde, Opeyemi O.
name: Ensor, Joie
name: Littlewood, Chris
name: Chesterton, Linda
name: Jordan, Joanne L.
name: Corp, Nadia
name: Wynne-Jones, Gwenllian
name: Roddy, Edward
name: Foster, Nadine E.
name: van der Windt, Danielle A.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified

description: Supplemental material, sj-doc-2-tab-10.1177_1759720X211037530 for Comparative effectiveness of treatment options for subacromial shoulder conditions: a systematic review and network meta-analysis by Opeyemi O. Babatunde, Joie Ensor, Chris Littlewood, Linda Chesterton, Joanne L. Jordan, Nadia Corp, Gwenllian Wynne-Jones, Edward Roddy, Nadine E. Foster and Danielle A. van der Windt in Therapeutic Advances in Musculoskeletal Disease
Table S1 - Supplemental material for The Utility of IL-17 Inhibitors in Neutrophilic Dermatoses: A Systematic Review
Creators: name: Elsawi, Rawaan
name: Brooks, Stephanie G.
name: Georgakopolous, Jorge R.
name: Lansang, Perla
name: Piguet, Vincent
name: Croitoru, David
Publisher: name: SAGE Journals
Year: 2021
Subjects: Medicine

description: Supplemental material, Table S1, for The Utility of IL-17 Inhibitors in Neutrophilic Dermatoses: A Systematic Review by Rawaan Elsawi, Stephanie G. Brooks, Jorge R. Georgakopolous, Perla Lansang, Vincent Piguet and David Croitoru in Journal of Cutaneous Medicine and Surgery
Additional file 4 of Supraphysiologic doses of 17β-estradiol aggravate depression-like behaviors in ovariectomized mice possibly via regulating microglial responses and brain glycerophospholipid metabolism
Creators: name: Li, Ming
name: Zhang, Jing
name: Chen, Wendi
name: Liu, Shuang
name: Liu, Xin
name: Ning, Yunna
name: Cao, Yongzhi
name: Zhao, Yueran
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health

description: Additional file 4: Table S1. Primers and their sequences used for the quantitative real time PCR. Table S2. Primers and their sequences of siRNA duplexes for gene knockdown experiments.
Multi Planar Conditional Generative Adversarial Networks
Creators: name: Mitra, Somosmita
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Digital processor architectures
Other information and computing sciences not elsewhere classified

description: Brain tumor sub region segmentation is a challenging problem in Magnetic Resonance imaging. The tumor regions tend to suffer from lack of homogeneity, textural differences, variable location, and their ability to proliferate into surrounding tissue. The segmentation task thus requires an algorithm which can be indifferent to such influences and robust to external interference. In this work we propose a conditional generative adversarial network which learns off multiple planes of reference. Using this learning, we evaluate the quality of the segmentation and back propagate the loss for improving the learning. The results produced by the network show competitive quality in both the training and the testing data-set.
Filter(n) – Geschichte Ästhetik Praktiken
Creators: name: Bäcker, Theresia
name: Kathöfer, Jasmin
name: Schulz, Christian
name: Winkler, Hartmut
name: Miggelbrink, Monique
name: Becker, Ilka
name: Heilmann, Till A.
name: Föllmer, Golo
name: Papenburg, Jens-Gerrit
name: Matzner, Tobias
name: Heidenreich, Stefan
name: Schröter, Jens
name: Seth, Erik Arkadi
Publisher: name: Universitätsbibliothek Siegen
Year: 2020
Subjects: subject: 302.23 Medien (Kommunikationsmittel), Medienwissenschaft
subject: Filter
subject: Geschichte
subject: Ästhetik
subject: Praktiken
subject: Medienwissenschaft
subject: Medienästhetik
subject: Informationsfilterung

description: Bei genauer Betrachtung scheint es, als sei der Filter allgegenwärtig: Von alltäglichen Gebrauchsgegenständen wie z.B. Kaffee-, Aktivkohle- und Pollenfiltern über den Moog Ladder Filter beim Moog Synthesizer, automatisierte Software-Filter im Zuge von Bewerbungsverfahren, bis hin zur 2016 im amerikanischen Präsidentschafts-Wahlkampf viel beschworenen Filter-Bubble oder eben fotografischen Filter-verfahren, wie sie derzeit prominent in einer Reihe von Apps Anwendung finden. Trotz dieser Präsenzen des Filters wurden in der Medien- und Kulturwissenschaft Operationen und Technologien des Filterns bislang weder systematisch noch in ihrer ganzen Bandbreite thematisiert. Ziel des Heftes ist es, hierzu einen Anstoß zu geben und sich mit dem Filter, aber auch mit den Praktiken des Filterns, seiner Geschichte und seinen Ästhetiken zu beschäftigen. Die Beiträge verhandeln dabei ganz unterschiedliche Beispiele: von Wahrnehmungsfiltern über Photoshop und Filtern in der Musik hin zu einer Ökonomie des Filter(n)s und dem Prozess der Verdauung.
Suicide Deaths: Do Socioecological Factors Differ by Rurality
Creators: name: Felix, William Thomas
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Public health not elsewhere classified

description: Objectives The study will assess patterns of known individual, interpersonal, and community-level circumstances leading to suicide to understand how these factors can co-occur. These patterns will help focus on prevention strategies.Methods Data was collected from the Iowa Violent Death Reporting System, Census data from the American Community Survey, and 2010 rural-urban commuting area codes from the Economic Research Service. The study consisted of three steps. The first step latent class analysis was conducted on data from suicide deaths from Iowa in 2016-2018 to create classes of patterns of circumstances leading to suicide. The second step maximum probability assignment was used to assign the sample of 1,276 to the created latent classes. Finally, in the third step bivariate regressions were ran to understand the relationship between the created latent classes and the rurality variable (nonmetropolitan vs metropolitan).Results Five latent classes of distinct patterns of suicide factors emerged. Class 1 is physical health problems living in areas that are average on all community-level variables. This class 1 is seen to happen with higher odds in nonmetropolitan areas. Class 2 is interpersonal problems in areas where living alone is high. This class 2 happened with higher odds in nonmetropolitan areas. Class 3 is mental health problems or depressed mood with no legal problems in areas that had lower educational attainment. This class 3 did not indicate greater odds based on rurality. Class 4 is history of mental health treatment in well-off areas. This class 4 was seen to happen with higher odds in metropolitan areas. Class 5 is substance abuse problems in poorer areas. This class 5 did not indicate greater odds based on rurality. All the classes shared a common theme of experiencing mental health issues or being in a depressed mood.Conclusions Suicide is a complex concern that could be classified into several classes that have distinct patterns of suicide factors. These classes and patterns help with identifying what services and interventions are needed in certain communities. Overall, providing support in regards to mental health as well as intervening in childhood to support positive development may provide substantial mitigation to the odds of committing suicide. In investigating these patterns, future prevention and intervention effort can take into consideration these patterns to tailor to the individual and the environments where they live.
Additional file 5 of Supraphysiologic doses of 17β-estradiol aggravate depression-like behaviors in ovariectomized mice possibly via regulating microglial responses and brain glycerophospholipid metabolism
Creators: name: Li, Ming
name: Zhang, Jing
name: Chen, Wendi
name: Liu, Shuang
name: Liu, Xin
name: Ning, Yunna
name: Cao, Yongzhi
name: Zhao, Yueran
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health

description: Additional file 5： Original western blots.
In situ tomography investigation of crack growth in carbon fiber laminate composites during monotonic and cyclic loading
Creators: name: Morales, Alejandra Margarita Ortiz
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Aerospace engineering not elsewhere classified
Aerospace structures
Aerospace materials

description: As the use of fiber-reinforced polymer composites grows in aerospace structures, there is an emerging need to implement damage tolerant approaches. The use of in-situ synchrotron X-ray tomography enables direct observations of progressive damage relative to the microstructural features, which is studied in a T650/5320 laminate composite with varying layup orientations (using 45o and -45o plies) in a compact tension specimen geometry. Specifically, the interactions of micromechanical damage mechanisms at the notch tip were analyzed through 3D image processing as the crack grew. First, monotonic tests were conducted where X-ray tomography was acquired incrementally between the unloaded state and maximum load. The analysis of the monotonic tension specimens showed intralaminar cracking was dominant during crack initiation, delamination became prevalent during the later stages of crack progression, and fiber breakage was, in general, largely related to intralaminar cracking. After the monotonic tension analysis, modifications were made to the specimen geometry and the loading assembly, and fatigue tests were conducted, also using in-situ synchrotron X-ray tomography. Specifically, tomography images were acquired after select intervals of cyclic loading to examine the crack growth behavior up to 5802 cycles. The analysis of the fatigue tests showed that intralaminar cracking was also dominant, while localized delamination allowed ply cross-over. A finite element analysis was conducted by comparing the crack profile at varying intervals of loading, and the change in stored energy per cycle, dU/dN, was calculated. The combined experimental and simulation analysis showed that when the per ply values of dU/dN were examined, the intralaminar cracking rate collapsed to one curve regardless of the ply orientation, where direct observations of fiber bridging were characterized and associated with a reduction in crack growth rate for the influenced ply. Overall, this work provides a physical understanding of the micromechanics facilitating intralaminar crack growth in composites, providing engineers the necessary assessments for slow crack growth approaches in structural composite materials.
Additional file 3 of Metabolic syndrome biomarkers relate to rate of cognitive decline in MCI and dementia stages of Alzheimer’s disease
Creators: name: Pillai, Jagan A.
name: Bena, James
name: Bekris, Lynn
name: Kodur, Nandan
name: Kasumov, Takhar
name: Leverenz, James B.
name: Kashyap, Sangeeta R.
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health

description: Additional file 3: Supplementary Table 2. Associations between TG/HDL, APOA1 and AD and inflammatory biomarkers in Dementia patients
Adapting Neural Network Learning Algorithms for Neuromorphic Implementations
Creators: name: Allred, Jason M
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Digital processor architectures
Other information and computing sciences not elsewhere classified
Electrical engineering not elsewhere classified

description: Computing with Artificial Neural Networks (ANNs) is a branch of machine learning that has seen substantial growth over the last decade, significantly increasing the accuracy and capability of machine learning systems. ANNs are connected networks of computing elements inspired by the neuronal connectivity in the brain. Spiking Neural Networks (SNNs) are a type of ANN that operate with event-driven computation, inspired by the “spikes” or firing events of individual neurons in the brain. Neuromorphic computing—the implementation of neural networks in hardware—seeks to improve the energy efficiency of these machine learning systems either by computing directly with device physical primitives, by bypassing the software layer of logical implementations, or by operating with SNN event-driven computation. Such implementations may, however, have added restrictions, including weight-localized learning and hard-wired connections. Further obstacles, such as catastrophic forgetting, the lack of supervised error signals, and storage and energy constraints, are encountered when these systems need to perform autonomous online, real-time learning in an unknown, changing environment.
Adapting neural network learning algorithms for these constraints can help address these issues. Specifically, corrections to Spike Timing-Dependent Plasticity (STDP) can stabilize local, unsupervised learning; accounting for the statistical firing properties of spiking neurons may improve conversions from non-spiking to spiking networks; biologically-inspired dopaminergic and habituation adjustments to STDP can limit catastrophic forgetting; convolving temporally instead of spatially can provide for localized weight sharing with direct synaptic connections; and explicitly training for spiking sparsity can significantly reduce computational energy consumption.
sj-pdf-1-cps-10.1177_00104140211036042 – Supplemental Material for Effective Government and Evaluations of Democracy
Creators: name: Claassen, Christopher
name: Magalhães, Pedro C.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160607 International Relations
subject: FOS: Political science

description: Supplemental Material, sj-pdf-1-cps-10.1177_00104140211036042 for Effective Government and Evaluations of Democracy by Christopher Claassen and Pedro C. Magalhães in Comparative Political Studies
sj-pdf-3-sjs-10.1177_14574969211042457 – Supplemental material for The impact of cirrhosis on the postoperative outcomes of patients undergoing splenectomy: Propensity score matched analysis of the 2011–2017 US hospital database
Creators: name: Lee, David U.
name: Fan, Gregory H.
name: Hastie, David J.
name: Addonizio, Elyse A.
name: Karagozian, Raffi
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110323 Surgery
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-3-sjs-10.1177_14574969211042457 for The impact of cirrhosis on the postoperative outcomes of patients undergoing splenectomy: Propensity score matched analysis of the 2011–2017 US hospital database by David U. Lee, Gregory H. Fan, David J. Hastie, Elyse A. Addonizio and Raffi Karagozian in Scandinavian Journal of Surgery
Personality traits, anxiety, depression in gynecological cancer
Creators: name: IUSO, SALVATORE
Publisher: name: Universit� degli Studi di Foggia
Year: 2018

description: Fino al 30% -40% delle persone affette da neoplasia riportano sintomi di ansia sufficientemente gravi da raggiungere i livelli clinici, esacerbando i sintomi fisici e compromettendo la qualit� della vita. Il polimorfismo genetico del trasportatore della serotonina (SERT) assume un ruolo rilevante nell?aumento del rischio di depressione in soggetti che subito un evento stressante. La neurotrasmissione della serotonina (5-HT) influenza un'ampia variet� di processi fisiologici e psicologici, comprese le differenze individuali nei tratti della personalit�. In questo studio, 40 pazienti oncologici ginecologici sono state reclutate dal Dipartimento di Ginecologia dell'Universit� di Foggia tra gennaio 2014 e dicembre 2016. Il Dipartimento di Genetica Medica Dipartimento di Scienze Mediche dell'Universit� di Foggia si � occupato dell'analisi del DNA. Le analisi dei gruppi genotipici 5HTT-LPR (gruppo S (s / s + s / l); l / 1; l / s; s / s) hanno indicato un significativo effetto principale del genotipo s / s sul nevroticismo (p = .0096), sui sintomi depressivi (p = 0.0407), sulla dimensione caratteriale della cooperativit� (p = 0.0064). Abbiamo trovato un effetto principale del nevroticismo sui sintomi depressivi (r = 0,7988, p ? 0,0001), sull?ansia di stato (r = 0,7343, p ? 0,0001) e sullo stress percepito (r = 0,5863, p ? 0,0001 ). La correlazione tra neuroticismo e qualit� della vita � negativa (r = -0,3190, p = 0,0421). Neuroticismo e sintomi depressivi prevalgono nella popolazione del cancro della cervice. Sintomi depressivi e stati emotivi negativi (Tensione-Ansia, Affaticamento-inerzia, Confusione-Sconcerto) prevalgono nella popolazione sottoposta alla chemio-radio. I disturbi dello spettro depressivo nei pazienti oncologici dovrebbero essere presi seriamente in considerazione, poich� depressione ha l'effetto peggiorativo sulla qualit� della vita e sull'incremento della disabilit� rispetto alle altre condizioni croniche. Pertanto, � opportuno che gli operatori sanitari che lavorano in oncologia, come oncologi, chirurghi, oncologi delle radiazioni, medici di base, infermieri, assistenti sociali e psicologi, ricevano una formazione nella diagnosi e nella gestione dei disturbi dello spettro depressivo, dato il diverso intervento approcci secondo il tipo di disturbo depressivo.
sj-docx-1-joo-10.1177_14653125211048202 – Supplemental material for The effectiveness of interventions to increase patient involvement in decision-making in orthodontics: A systematic review
Creators: name: Shelswell, Jonathan
name: Patel, Veena Abigale
name: Barber, Sophy
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110599 Dentistry not elsewhere classified
subject: FOS: Clinical medicine

description: Supplemental material, sj-docx-1-joo-10.1177_14653125211048202 for The effectiveness of interventions to increase patient involvement in decision-making in orthodontics: A systematic review by Jonathan Shelswell, Veena Abigale Patel and Sophy Barber in Journal of Orthodontics
A novel biomarker for cancer and autoimmune diseases: IGFBP6
Creators: name: TROTTA, ROSA
Publisher: name: Universit� degli Studi di Foggia
Year: 2019

description: La temperatura corporea costituisce un importante meccanismo di difesa ed � il risultato di una complessa interazione che coinvolge numerosi fattori. Nell'uomo sano, la temperatura corporea � finemente regolata; deviazioni di 0.5�C oltre il limite superiore possono indicare una condizione patologica. Numerosi agenti possono indurre ipertermia, tra cui, insufficienza cardiaca acuta/cardiomiopatia acuta da stress [1] e infarto miocardico acuto [2] sindrome neurolettica maligna [3], endocrinopatie [4, 5], disturbi del sistema nervoso centrale (SNC) [6] e patologie oncologiche [7]. Le temperature febbrili aumentano l'efficacia della risposta immunitaria durante le infezioni stimolando il sistema immunitario innato e adattativo. Questo studio ha come obiettivo quello di dimostrare come l'ipertermia possa indurre modifiche del profilo di espressione genica e di evidenziare nuovi marker precoci di prognosi/diagnosi in patologie autoimmuni e/o tumorali. Nelle cellule dendritiche, alcuni tra i geni up-regolati codificano per proteine secrete, come IGFBP6 [8]. In condizioni ipertermiche, questa proteina induce chemiotassi dei monociti, dei linfociti T, ma non dei linfociti B. Inoltre, IGFBP6 � un agonista selettivo nei neutrofili poich� aumenta sia il burst ossidativo che la degranulazione e agisce come fattore chemotattico.
sj-docx-1-jbm-10.1177_17246008211035142 - Supplemental material for Serum epithelial membrane protein 1 serves as a feasible biomarker in extrahepatic cholangiocarcinoma
Creators: name: Li, Xiang
name: Yan, Lang
name: Xue, Hao
Publisher: name: SAGE Journals
Year: 2021
Subjects: Oncology and Carcinogenesis not elsewhere classified

description: Supplemental material, sj-docx-1-jbm-10.1177_17246008211035142 for Serum epithelial membrane protein 1 serves as a feasible biomarker in extrahepatic cholangiocarcinoma by Xiang Li, Lang Yan and Hao Xue in The International Journal of Biological Markers
sj-docx-2-jbm-10.1177_17246008211035142 - Supplemental material for Serum epithelial membrane protein 1 serves as a feasible biomarker in extrahepatic cholangiocarcinoma
Creators: name: Li, Xiang
name: Yan, Lang
name: Xue, Hao
Publisher: name: SAGE Journals
Year: 2021
Subjects: Oncology and Carcinogenesis not elsewhere classified

description: Supplemental material, sj-docx-2-jbm-10.1177_17246008211035142 for Serum epithelial membrane protein 1 serves as a feasible biomarker in extrahepatic cholangiocarcinoma by Xiang Li, Lang Yan and Hao Xue in The International Journal of Biological Markers
Gießener Universitätsblätter 56 (2023)
Creators: name: (:Unkn) Unknown
name: Justus Liebig University Giessen
Publisher: name: Justus-Liebig-Universität Gießen
Year: 2023
Subjects: subject: ddc:000

description: Enthält u.a.: Juri Andruchowytsch: Der Preis der Zukunft. Vom Wesen des „aufgeschobenen Krieges“ Frank Mehring: Nenn es Freiheit, oder nenn es Liebe – Call it liberty, or call it love Laudatio zur Enthüllung der Gedenktafel von Karl Theodor Christian Follen (1796–1840) Lutz Trautmann: Erinnerung an Wulf Emmo Ankel (1897–1983) Professor für Zoologie und Rektor der Universität in Gießen Martin Spies: Aus Marie250 wird Marie300 Oder: der lange Weg vom Projektseminar zur Wanderausstellung über Marie von Hessen-Kassel (1723–1772) Marcus Kiefer, Sigrid Ruby: Hein Heckroth (1901–1970) – Bühnenbildner, Filmdesigner, Maler. Bausteine einer Werkbiografie Interdisziplinärer Workshop des Instituts für Kunstgeschichte der Justus-Liebig-Universität Gießen und der Hein-Heckroth-Gesellschaft Gießen e.V. in Zusammenarbeit mit dem Oberhessischen Museum Gießen (23. und 24. Juni 2022) Klaus T. Preissner: Vom Molekül zur Medizin: Forschen, um zu helfen. Ein wissenschaftliches Interview
Redox Active Ligands To Facilitate Reactivity From Redox Restricted Metals
Creators: name: Hewitt, Matthew C
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Organic chemical synthesis
F-block chemistry
Transition metal chemistry
Organometallic chemistry

description: The synthesis of metal-redox active ligand complexes is described, along with reactivity studies aimed at facilitating novel C-N bond forming reactions. A copper bis(iminosemiquinone) structure is characterized, analyzed and its reduction series are characterized and the reactivity of the Cu(II) bis(amidophenolate) analog is investigated with tosyl azide. The identification of the major reaction product and its characterization is detailed, with reaction sensitivities and heavily distorted x-ray diffraction single crystal structure generating a complex data set. The characterization of the isolated product is ongoing, with EPR studies aimed at identifying the radical nature of the complex. Unusual solvent effects and solubility issues have been noted with these initial EPR studies and more data is necessary before analysis can be properly attempted. An ytterbium bis(amidophenolate) complex was synthesized and its reactivity studied with aryl azides. Initial reactivities generate the first documented lanthanide tetrazenes in-lieu of the targeted ytterbium imido. Reactivities and characterization of these complexes support a stable, heavily ionic tetrazene-metal complex with no observed redox nature, UV light sensitivities, or imido azide-tetrazene equilibrium observed in various tetrazene transition metal complexes. Synthesis of a sterically blocked ytterbium imido was attempted, utilizing DMAP. Initial isolation was achieved with characterization and reactivity studies supporting the imido nature of the complex. The weak coordinating of the DMAP provided instability that proved in opposition to crystallization, however, so the imido could not be confirmed. Initial reactions using alternative steric hinderance from triphenylphosphine oxide and pyridine N-oxide prove promising to increasing the stability of the presumed ytterbium imido. Organic synthesis was performed generating a potential antibacterial agent. The synthesis of cyclopropenes was initiated as antagonists for ETR proteins in fruits and plants. The intermediates proved highly sensitive to harsh chemical conditions, which was overcome utilizing a tin-mediated Barbier allylation. The cyclopropene alcohol synthon was synthesized, though protecting group optimization is necessary.
Renin–angiotensin system inhibition and mortality in patients undergoing dialysis with coronary artery disease: insights from a multi-center observational study
Creators: name: Xie, Enmin
name: An, Shuoyan
name: Wu, Yaxin
name: Ye, Zixiang
name: Zhao, Xuecheng
name: Li, Yike
name: Shen, Nan
name: Gao, Yanxiang
name: Zheng, Jingang
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Cancer

description: While the survival benefits of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) are firmly established in the general population, their efficacy within patient undergoing dialysis with coronary artery disease (CAD) remains controversial. Between January 2015 and June 2021, 1168 patients undergoing dialysis with CAD were assessed from 30 tertiary medical centers. The primary outcome was all-cause death, and the secondary outcome was cardiovascular death. Inverse probability of treatment weighting (IPTW) and propensity score matching (PSM) were performed to account for between-group differences. Overall, ACEI or ARB were prescribed to 518 patients (44.3%) upon discharge. After a median follow-up of 22.2 months, 361 (30.9%) patients died, including 243 cardiovascular deaths. The use of ACEI or ARB was associated with a significantly lower risk of all-cause (25.3% vs 35.4%, hazard ratio [HR] 0.65, 95% confidence interval [CI] 0.52–0.82, p < 0.001) and cardiovascular death (17.0% vs 23.8%; HR 0.64, 95% CI 0.48–0.83, p = 0.001). These findings remained consistent across IPTW and PSM analyses. Sensitivity analyses for ACEI and ARB use separately yielded similar results. Our findings suggested that among patients undergoing dialysis with CAD, ACEI or ARB use was associated with a lower risk of all-cause and cardiovascular death.
Ozone and electrolized water application to preserve quality of citrus fruit and effect of ozone on gene expression related to plant defense mechanisms
Creators: name: DAMARA, EYAD
Publisher: name: Universit� degli Studi di Foggia
Year: 2017

description: In this work the effect of ozone (O3), electrolyzed water (EW) in combination with passive refrigeration conservation system (PRS) on fruit quality was studied during postharvest. The amount of Colony Forming Units (CFUs) on fruit surface, shelf life (McKinney index), firmness and sugar content were evaluated during the conservation period of Citrus (cv. Navel orange and cv. Clementine commune), cherry (cv. Ferrovia) and table grape (cv. Redglobe, Crimson and Italia). O3 and EW dose and exposure time were set in in vitro experiment. O3 was used in washing water or as gas during storage. Results demonstrate that the combination of O3, EW and PRS treatments reduce microorganism contamination and increase fruits hardness and sugar content. An extension of fruit shelf-life was also evidenced. Elicitors are agents that can induce a range of defense mechanisms in citrus tissue. This characteristic results in a broad spectrum of metabolic modifications such as Systemic Acquired Resistance (SAR), Induced Systemic Resistance (ISR) and production of Reactive Oxygen Species (ROS). In the present study we investigated the expression level of genes that encode Beta-1,3 glucanase (GNS1), Chitinase (CHI1), Phenylalanine-Ammonia Lyase (PAL1) and Peroxidase (POD1) in Navel sweet orange treated with two elicitors: ozone and Penicillium digitatum. Quantitative Reverse Transcriptase PCR (qRTPCR) showed that ozone applied singly increased the transcription of (GNS1) and (CHI1) with a fold change of 22 and 21 above the levels observed for the control at 24 hours and 48 hours after treatment. Unexpectedly, P.digitatum inoculation followed by ozone treatment was weakly effective in enhancing the tested genes. Overall, we consider that ozone can enhance the genes related to SAR (CHI1 and GNS1) in non-inoculated fruits. Therefore, ozone can be used as post-harvest treatment immediately after picking, before the exposure of fruits to pathogens. This lead to suggest fruit washing with EW storing in PRS under ozonized atmosphere, to counteract a pathogenic attack or in general a stress event.
Characterization Of Enzymes For The Food Industry And Active Packaging
Creators: name: MIRABELLI, VALENTINA
Publisher: name: Universit� degli Studi di Foggia
Year: 2018

description: I vantaggi dell?utilizzo di enzimi al posto di reagenti chimici nei processi industriali e le loro applicazioni ad ampio spettro sono oggi comunemente noti, ma negli ultimi decenni si assiste ad un passaggio dall?uso di enzimi liberi in soluzione a quello di enzimi immobilizzati. In particolare, nell?industria alimentare, un enzima immobilizzato si trova spesso come agente funzionale nel cosiddetto ?imballaggio attivo?. Tra gli enzimi utilizzati per scopi industriali, la laccasi (E.C. 1.10.3.2.) � certamente uno dei pi� sfruttati e versatili, grazie alla sua larga specificit� per substrati ed al suo potenziale ossido-riduttivo modulabile in diverse condizioni di lavoro. E? stato riportato per esempio che una laccasi da fungo � in grado di degradare alcune micotossine. In questo lavoro di dottorato, sono stati condotti studi su enzimi da utilizzare per applicazioni nel campo degli imballaggi alimentari. Una isoforma fungina di laccasi ricombinante, espressa in lievito, � stata immobilizzata in forma attiva su membrane di idrogel. Sono stati condotti studi funzionali in vitro e su matrice alimentare. I risultati hanno mostrato che l?enzima ricombinante, accoppiato ad un opportuno mediatore, � efficace nel degradare micotossine altamente diffuse e pericolose come l?aflatossina M1 e l?aflatossina B1. Un?altra laccasi fungina � stata espressa in batteri, ma la purificazione non ha dato un prodotto funzionale. Come seconda soluzione per imballaggi alimentari, il lisozima � stato scelto quale agente antimicrobico nella sua forma cristallina, ovvero cristalli di proteina sono stati fatti crescere su materiali avanzati composti da strati di idrogel su supporto di membrana idrofobica (membrane-idrogel composite). Test in vitro hanno dimostrato che l?attivit� antimicrobica di questa nuova soluzione di imballaggio risulta essere pi� efficiente dell?attivit� dell?enzima libero. Ad oggi questo � il primo studio riguardante l?applicazione di enzimi cristallizzati in imballaggi alimentari.
New Age: The Lives Of Mothers And Babies In The Balkan Neolithic
Creators: name: Stefanović, Sofija
name: Vlajnić, Damir
Publisher: name: Zenodo
Year: 2017
Subjects: child care
Balkans
exhibition catalogues

description: Exhibition "NEW AGE: the lives of mothers and babies in the Balkan Neolithic" is a result of the project BIRTH: Birth, mothers and babies: prehistoric fertility in Balkans between 10000-5000 BC, funded by the European Research Council (ERC) under the European Union's research and innovation programme Horizon2020 (Grant Agreement no. 640557).
Additional file 1 of Metabolic syndrome biomarkers relate to rate of cognitive decline in MCI and dementia stages of Alzheimer’s disease
Creators: name: Pillai, Jagan A.
name: Bena, James
name: Bekris, Lynn
name: Kodur, Nandan
name: Kasumov, Takhar
name: Leverenz, James B.
name: Kashyap, Sangeeta R.
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Mental Health

description: Additional file 1. Supplementary material
Sharing/collaborative economy: confini giuridici e prospettive di regolazione: il caso Uber
Creators: name: ZILIANTI, MARTA
Publisher: name: Luiss Guido Carli
Year: 2020

description: Sharing economy e collaborative economy: uno sguardo d?insieme a una nuova frontiera giuridica. La regolazione della sharing economy e il caso Uber: trasporto pubblico non di linea e criticit� connesse. Ancora sul caso uber: possibili rimedi e soluzioni all?attuale impasse
PREDICTORS OF EARLY POSTSECONDARY STEM PERSISTENCE OF HIGH-ACHIEVING STUDENTS: AN EXPLANATORY STUDY USING MACHINE LEARNING TECHNIQUES
Creators: name: Karakis, Nesibe
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Other education not elsewhere classified
Educational psychology

description: This study investigated high-achieving and non-high-achieving students’ persistence in STEM fields using nationally representative data from the High School Longitudinal Study of 2009 for the years 2009, 2012, 2013, 2013-2014, and 2016. The results indicated that approximately 70% of high-achieving and non-high-achieving students continued their initial STEM degrees within 3 years of college enrollment. The study revealed that the most important predictors of STEM persistence were: math proficiency level, school belonging, school engagement, school motivation, school problems, science self-efficacy, credits earned in computer sciences, GPA in STEM courses, credits earned in STEM courses, and credits earned in Advanced Placement/International Baccalaureate (AP/IB) courses. Based on the results, math proficiency was the most important variable in the study for both high-achieving and non-high-achieving students. Even though credits earned in AP/IB combined were among the most important variables, they were two times more important for high-achieving students (6.86% vs. 3.37%). Regarding demographic information related variables, socioeconomic status was the most important variable among gender, ethnicity, and urbanicity in models predicting STEM persistence and had higher importance for non-high-achieving students. Furthermore, Hispanic students' proportion of persistence differed from other underrepresented populations’ persistence. Non-high-achieving Hispanic students had the highest persistence rate, similar to well-represented populations (i.e., White, Asian). Machine learning methods used in the study including random forest and artificial neural network provided good accuracy for both achievement groups. Random forest accuracy was over 82% with the Synthetic Minority Over-Sampling Technique (SMOTE) dataset, while artificial neural network accuracy was over 92%.
L?equity based crowdfunding e lo statuto dell?emittente
Creators: name: BONCRISTIANO, FEDERICA
Publisher: name: Universit� degli Studi di Foggia
Year: 2019

description: Tema della ricerca di dottorato � l?equity crowdfunding, meccanismo di finanziamento alternativo al tradizionale canale del credito bancario, che coinvolge attraverso portali internet il pubblico dei piccoli investitori. L?istituto dell?equity crowdfunding � stato introdotto nell?ordinamento italiano con il d.l. n. 179/2012, noto Decreto Crescita -bis, inizialmente per favorire il finanziamento delle sole start-up innovative, e poi, con successive riforme, la platea degli emittenti � stata ampliata a tutte le piccole e medie imprese. L?obiettivo del lavoro � stato studiare sia l?impatto delle deroghe alle norme di diritto comune delle societ�, in particolare alla disciplina delle societ� a responsabilit� limitata, sia analizzare il valore delle regole di autonomia privata, previste dai gestori dei portali di equity crowdfunding per la pubblicazione delle offerte, all?interno del sistema delle fonti. La tesi � stata strutturata in cinque capitoli. La presente tesi di dottorato � stata strutturata in cinque capitoli. Nel primo capitolo, dopo una panoramica sulle fonti di finanziamento extra bancarie per le SMEs, si ripercorre l?evoluzione della regolamentazione italiana dell?equity crowdfunding; il secondo � dedicato sia all?analisi comparata del fenomeno sia alle prospettive comunitarie in jure condendo; il terzo si occupa dell?analisi delle deroghe introdotte al diritto societario comune delle societ� a responsabilit� limitata.; il quarto capitolo � incentrato sulla figura dei gestori dei portali di equity crowdfunding; infine, l?ultimo analizza la natura delle regole di autonomia privata adottate dai portali e la loro collocazione nel sistema delle fonti del diritto.
D4.1 Bigdataocean Technology Requirements And User Stories
Creators: name: Project Consortium Members
Publisher: name: Zenodo
Year: 2017

description: This deliverable is related to the activities to be performed under Tasks 3.1 and 3.2 and  provides the user stories, as well as the technology and data protection requirements for the BigDataOcean platform, as envisioned by the different user groups and will flesh out the concept.
description: Disclaimer: The BigDataOcean project is co-funded by the Horizon 2020 Programme of the European Union. This document reflects only authors' views. The EC is not liable for any use that may be done of the information contained therein
D4.2 Bigdataocean Platform Architecture, Components Design And Apis - V1.00
Creators: name: Project Consortium Members
Publisher: name: Zenodo
Year: 2018

description: This deliverable includes the requirements, the architecture diagrams and all design documents regarding the platform, the components while it also defines and describes the API interfaces that are implemented.
description: Disclaimer: The BigDataOcean project is co-funded by the Horizon 2020 Programme of the European Union. This document reflects only authors' views. The EC is not liable for any use that may be done of the information contained therein
D4.3 Bigdataocean Platform Architecture, Components Design And Apis – V2.00
Creators: name: Project Consortium Members
Publisher: name: Zenodo
Year: 2018

description: This deliverable includes all necessary updates on the platform and components’ architecture, as well as the APIs interfaces, based on the feedback received by the project’s pilots.
description: Disclaimer: The BigDataOcean project is co-funded by the Horizon 2020 Programme of the European Union. This document reflects only authors' views. The EC is not liable for any use that may be done of the information contained therein
Mutational analysis of Kabuki Syndrome patients and functional dissection of KMT2D mutations
Creators: name: COCCIADIFERRO, DARIO
Publisher: name: Universit� degli Studi di Foggia
Year: 2018

description: The discovery of histone methyltransferase KMT2D and demethylase KDM6A genetic alterations in Kabuki Syndrome (KS) expanded and highlighted the role of histone modifiers in causing congenital anomalies and intellectual disability syndromes. KS is a rare autosomal dominant condition characterized by facial features, various organ malformations, postnatal growth deficiency, and intellectual disability. Since 2011 we performed a mutational screening of our KS cohort, that includes now 505 KS patients, by Sanger sequencing and MLPA of KMT2D, followed by KDM6A analysis in those patients resulted as KMT2Dnegative. Of these 505 patients, we identified 196/505 (39%) patients with KMT2D variants and 208 different KMT2D variations; of them 37/208 (18%) never described before. The majority of KS patients carry nonsense and splicesite variants, suggesting the loss of function, and therefore haploinsufficiency, as the likely mechanism for the KS phenotype. RT-PCR and direct sequencing on cDNA from Kabuki patients carrying KMT2D splice site variants demonstrated that these cause aberrant splicing of the corresponding transcript, resulting in a truncating and not functional translated protein. Molecular assays also showed that KMT2D mRNAs bearing premature stop codon are degraded by the nonsense mediated mRNA decay, contributing to KMT2D protein haploinsufficiency. We hypothesized that KS patients may benefit from a readthrough therapy that mediates translational suppression of nonsense variants, restoring the physiologically levels of endogenous KMT2D protein. Fourteen KMT2D nonsense variants were tested for their response to readthrough treatment through an in vitro dual reporter luciferase vector system, identifying 11/14 variants that displayed high levels of readthrough in response to gentamicin treatment. Among our cohort we identified three new cases with a mosaic variants in KMT2D gene, consisting in single nucleotide change resulting in two already reported nonsense variants, the c.13450C=/>T (p.R4484X) and the c.15061C=/>T (p.R5021X) and in a new frameshift variant, the c.3596_3597=/del (p.L1199HfsX7) KMT2D, respectively. Moreover, relevant for diagnostic and counselling purposes, we implemented a number of bioinformatics tools to assess the pathogenicity of 69 KMT2D missense variants, found overall in our cohort of 505 KS patients, and for 14 of them we adopted a combination of biochemical and cellular approaches to investigate their role and characterize their functional impact in the pathogenesis of the disease. We found 9/14 missense variants showing altered H3K4 methylation activity. We additionally assessed the impact on complex formation with WRAD protein complex, and we found that the reduced methyltransferase activity could be a consequence of lack of interaction.