cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Essential role of the HMG domain in the function of yeast mitochondrial histone HM: functional complementation of HM by the nuclear nonhistone protein NHP6A.
Creators: name: Chae, C. B.
name: Kao, L. R.
name: Megraw, T. L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1993

description: The yeast mitochondrial histone protein HM is required for maintenance of the mitochondrial genome, and disruption of the gene encoding HM (H1M1/ABF2) results in formation of a respiration-deficient petite mutant phenotype. HM contains two homologous regions, which share sequence similarity with the eukaryotic nuclear nonhistone protein, HMG-1. Experiments with various deletion mutants of HM show that a single HMG domain of HM is functional and can restore respiration competency to cells that lack HM protein (him1 mutant cells). The gene encoding the putative yeast nuclear HMG-1 homolog, the NHP6A protein, can functionally complement the him1 mutation.The yeast mitochondrial histone protein HM is required for maintenance of the mitochondrial genome, and disruption of the gene encoding HM (H1M1/ABF2) results in formation of a respiration-deficient petite mutant phenotype. HM contains two homologous regions, which share sequence similarity with the eukaryotic nuclear nonhistone protein, HMG-1. Experiments with various deletion mutants of HM show that a single HMG domain of HM is functional and can restore respiration competency to cells that lack HM protein (him1 mutant cells). The gene encoding the putative yeast nuclear HMG-1 homolog, the NHP6A protein, can functionally complement the him1 mutation.
Molecular resurrection of an extinct ancestral promoter for mouse L1.
Creators: name: Adey, Nils B.
name: Edgell, Marshall Hall
name: Hutchison III, Clyde A.
name: Sparks, Andrew B.
name: Tollefsbol, Trygve O.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1994

description: The F-type subfamily of LINE-1 or L1 retroposonB [for long interspersed (repetitive) element 1] was dispersed in the mouse genome several million years ago. This subfamily appears to be both transcriptionally and transpositionally inactive today and therefore may be considered evolutionarily extinct. We hypothesized that these F-type L1s are inactive because of the accumulation of mutations. To test this idea we used phylogenetic analysis to deduce the sequence of a transpositionally active ancestral F-type promoter, resurrected it by chemical synthesis, and showed that it has promoter activity. In contrast, F-type sequences isolated from the modern genome are inactive.
A support theorem for Hilbert schemes of planar curves, II
Creators: name: Migliorini, Luca
name: Shende, Vivek
name: Viviani, Filippo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics

description: We study the cohomology of Jacobians and Hilbert schemes of points on reduced and locally planar curves, which are however allowed to be singular and reducible. We show that the cohomologies of all Hilbert schemes of all subcurves are encoded in the cohomologies of the fine compactified Jacobians of connected subcurves, via the perverse Leray filtration.
description: 38 pages, version 2. Major expository changes; some of the original arguments in the proof of the main theorem have been simplified
Subjective and objective measures of household resilience capacity in sub-Saharan Africa
Creators: name: D'Errico, Marco
name: Båsund, Karina Lisboa
name: D'Errico, Marco
name: Båsund, Karina Lisboa
Publisher: name: Unknown
Year: 2022
Subjects: subject: Consumer/Household Economics
subject: resilience
subject: subjective measures
subject: quantitative
subject: shocks
subject: cross-countries

description: Resilience plays an essential role in sustaining and improving people’s livelihood during environmental changes. While several resilience measurements approaches have emerged, few studies compare the use of different resilience measurement tools. This paper addresses this gap by investigating how subjectively evaluated resilience measurements compare and relate to objective measurement tools. Using regionally representative household data of 24,516 households in 9 countries, we investigate whether the Subjective selfEvaluated Resilience Score (SERS) can act as a substitute to the objectively evaluated Resilience Capacity Index (RCI) estimated through the Resilience Index and Measurement Analysis (RIMA) approach. We further examine how these measures capture the effect of experiencing climate and socio-economic shocks on resilience. Finally, we investigate the determinants of these measures. We find that overall, the correlations between SERS and RCI are weak and not consistent across countries. Further, we find that while several determinants have the same direction and almost the same magnitude of effect for both SERS and RCI. However, the effect of having experienced past shocks on these resilience capacity measurements differs as SERS decreases whereas RCI increases. We therefore conclude that SERS and RCI are not substitutes, and that they may be capturing various and different aspects of resilience capacities. This is essential to consider when designing targeting criteria for resilience-building projects and ensuring proper measurement and evaluation.
(3191) Helen May Tennant
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Function of von Willebrand factor after crossed bone marrow transplantation between normal and von Willebrand disease pigs: effect on arterial thrombosis in chimeras.
Creators: name: Reddick, Robert L.
name: Pignaud, George A.
name: Read, Marjorie S.
name: Bellinger, Dwight A.
name: Koch, Gary G.
name: Brinkhous, Kenneth M.
name: Vaiman, Marcel
name: Sigman, Jeff L.
name: Samama, C. Marc
name: Roussi, Jacqueline
name: Nichols, Timothy C.
name: Drouet, Ludovic
name: Bailliart, O.
name: Griggs, Thomas R.
name: Bonneau, Michel
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1995

description: von Willebrand factor (vWF) is essential for the induction of occlusive thrombosis in stenosed and injured pig arteries and for normal hemostasis. To separate the relative contribution of plasma and platelet vWF to arterial thrombosis, we produced chimeric normal and von Willebrand disease pigs by crossed bone marrow transplantation; von Willebrand disease (vWD) pigs were engrafted with normal pig bone marrow and normal pigs were engrafted with vWD bone marrow. Thrombosis developed in the chimeric normal pigs that showed normal levels of plasma vWF and an absence of platelet vWF; but no thrombosis occurred in the chimeric vWD pigs that demonstrated normal platelet vWF and an absence of plasma vWF. The ear bleeding times of the chimeric pigs were partially corrected by endogenous plasma vWF but not by platelet vWF. Our animal model demonstrated that vWF in the plasma compartment is essential for the development of arterial thrombosis and that it also contributes to the maintenance of bleeding time and hemostasis.
The Thin Ideology of Populist Advertising on Facebook during the 2019 EU Elections
Creators: name: Capozzi, Arthur
name: Morales, Gianmarco De Francisci
name: Mejova, Yelena
name: Monti, Corrado
name: Panisson, André
Publisher: name: arXiv
Year: 2023
Subjects: subject: Social and Information Networks (cs.SI)
subject: Computers and Society (cs.CY)
subject: FOS: Computer and information sciences

description: Social media has been an important tool in the expansion of the populist message, and it is thought to have contributed to the electoral success of populist parties in the past decade. This study compares how populist parties advertised on Facebook during the 2019 European Parliamentary election. In particular, we examine commonalities and differences in which audiences they reach and on which issues they focus. By using data from Meta (previously Facebook) Ad Library, we analyze 45k ad campaigns by 39 parties, both populist and mainstream, in Germany, United Kingdom, Italy, Spain, and Poland. While populist parties represent just over 20% of the total expenditure on political ads, they account for 40% of the total impressions$\unicode{x2013}$most of which from Eurosceptic and far-right parties$\unicode{x2013}$thus hinting at a competitive advantage for populist parties on Facebook. We further find that ads posted by populist parties are more likely to reach male audiences, and sometimes much older ones. In terms of issues, populist politicians focus on monetary policy, state bureaucracy and reforms, and security, while the focus on EU and Brexit is on par with non-populist, mainstream parties. However, issue preferences are largely country-specific, thus supporting the view in political science that populism is a "thin ideology", that does not have a universal, coherent policy agenda. This study illustrates the usefulness of publicly available advertising data for monitoring the populist outreach to, and engagement with, millions of potential voters, while outlining the limitations of currently available data.
Brackets in representation algebras of Hopf algebras
Creators: name: Massuyeau, Gwenael
name: Turaev, Vladimir
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Algebra (math.QA)
subject: Rings and Algebras (math.RA)
subject: FOS: Mathematics
subject: 17B63, 16T05

description: For any graded bialgebras $A$ and $B$, we define a commutative graded algebra $A_B$ representing the functor of $B$-representations of $A$. When $A$ is a cocommutative graded Hopf algebra and $B$ is a commutative ungraded Hopf algebra, we introduce a method deriving a Gerstenhaber bracket in $A_B$ from a Fox pairing in $A$ and a balanced biderivation in $B$. Our construction is inspired by Van den Bergh's non-commutative Poisson geometry, and may be viewed as an algebraic generalization of the Atiyah--Bott--Goldman Poisson structures on moduli spaces of representations of surface groups.
description: 57 pages. Very minor changes in this last version
(3187) John Clark
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Development of Classroom Management Based on Student Learning Style Database
Creators: name: Rahadian, Raditya Bayu
name: Budiningsih, C. Asri
Publisher: name: arXiv
Year: 2023
Subjects: subject: Physics Education (physics.ed-ph)
subject: FOS: Physical sciences

description: This study aims to produce a classroom management application based on a database of student learning styles to identify and analyze student learning styles and match them with appropriate learning methods and media. This application is expected to facilitate classroom management according to student preferences. This research was research and development. Respondents were 198 people consisting of 30 teachers and 168 students at a Junior High School in South Bangka Indonesia. The data analysis used quantitative data analysis techniques using descriptive statistics. The results showed that the application developed was feasible to be used to identify and analyze student learning styles and provide suggestions for learning methods and media that teachers should use in classroom management. The level of application eligibility in terms of technical aspects reaches 4.75 and the content aspect reaches 4.80. This application proved to be useful for teachers in class management as evidenced by the achievement of the usability test score by the teacher reaching 4.40. The usefulness of the application from the students perspective can be seen from the increase in the attractiveness of learning that occurs after the teacher uses this application compared to before.
Supplementary material from Asymmetric drop coalescence launches fungal ballistospores with directionality.
Creators: name: Fangjie Liu
name: Chavez, Roger L.
name: S. N. Patek
name: Pringle, Anne
name: Feng, James J.
name: Chen, Chuan-Hua
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: Biophysics
subject: 110601 Biomechanics
subject: FOS: Health sciences

description: Thousands of fungal species use surface energy to power the launch of their ballistospores. The surface energy is released when a spherical Buller's drop at the spore's hilar appendix merges with a flattened drop on the adaxial side of the spore. The launching mechanism is primarily understood in terms of energetic models, and crucial features such as launching directionality are unexplained. Integrating experiments and simulations, we advance a mechanistic model based on the capillary–inertial coalescence between the Buller's drop and the adaxial drop, a pair that is asymmetric in size, shape and relative position. The asymmetric coalescence is surprisingly effective and robust, producing a launching momentum governed by the Buller's drop and a launching direction along the adaxial plane of the spore. These key functions of momentum generation and directional control are elucidated by numerical simulations, demonstrated on spore-mimicking particles, and corroborated by published ballistospore kinematics. Our work places the morphological and kinematic diversity of ballistospores into a general mechanical framework, and points to a generic catapulting mechanism of colloidal particles with implications for both biology and engineering.
Epstein-Barr viral latency is disrupted by the immediate-early BRLF1 protein through a cell-specific mechanism.
Creators: name: Kenney, Shannon
name: Holley-Guthrie, Elizabeth
name: Zalani, Sunita
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: Epstein-Barr virus (EBV), the causative agent of infectious mononucleosis, is a human herpesvirus associated with epithelial cell malignancies (nasopharyngeal carcinoma) as well as B-cell malignancies. Understanding how viral latency is disrupted is a central issue in herpesvirus biology. Epithelial cells are the major site of lytic EBV replication within the human host, and viral reactivation occurs in EBV-associated nasopharyngeal carcinomas. It is known that expression of a single viral immediate-early protein, BZLF1, is sufficient to initiate the switch from latent to lytic infection in B cells. Cellular regulation of BZLF1 transcription is therefore thought to play a key role in regulating the stringency of viral latency. Here we show that, unexpectedly, expression of another viral immediate-early protein, BRLF1, can disrupt viral latency in an epithelial cell-specific fashion. Therefore, the mechanisms leading to disruption of EBV latency appear to be cell-type specific.
Shear instabilities in a fully compressible polytropic atmosphere
Creators: name: Witzke, V.
name: Silvers, L. J.
name: Favier, B.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Shear flows have an important impact on the dynamics in an assortment of different astrophysical objects including accreditation discs and stellar interiors. Investigating shear flow instabilities in a polytropic atmosphere provides a fundamental understanding of the motion in stellar interiors where turbulent motions, mixing processes, as well as magnetic field generation takes place. Here, a linear stability analysis for a fully compressible fluid in a two-dimensional Cartesian geometry is carried out. Our study focuses on determining the critical Richardson number for different Mach numbers and the destabilising effects of high thermal diffusion. We find that there is a deviation of the predicted stability threshold for moderate Mach number flows along with a significant effect on the growth rate of the linear instability for small Péclet numbers. We show that in addition to a Kelvin-Helmholtz instability a Holmboe instability can appear and we discuss the implication of this in stellar interiors.
description: 8 pages, 7 figures, accepted for publication in A&A
Structure of the replication terminus-terminator protein complex as probed by affinity cleavage.
Creators: name: White, Stephen W.
name: Bussiere, Dirksen E.
name: Bastia, Deepak
name: Wang, Fenggang
name: Pai, Karnire S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: The replication terminator protein (RTP) of Bacillus subtilis is a homodimer that binds to each replication terminus and impedes replication fork movement in only one orientation with respect to the replication origin. The three-dimensional structure of the RTP-DNA complex needs to be determined to understand how structurally symmetrical dimers of RTP generate functional asymmetry. The functional unit of each replication terminus of Bacillus subtilis consists of four turns of DNA complexed with two interacting dimers of RTP. Although the crystal structure of the RTP apoprotein dimer has been determined at 2.6-A resolution, the functional unit of the terminus is probably too large and too flexible to lend itself to cocrystallization. We have therefore used an alternative strategy to delineate the three dimensional structure of the RTP-DNA complex by converting the protein into a site-directed chemical nuclease. From the pattern of base-specific cleavage of the terminus DNA by the chemical nuclease, we have mapped the amino acid to base contacts. Using these contacts as distance constraints, with the crystal structure of RTP, we have constructed a model of the DNA-protein complex. The biological implications of the model have been discussed.
Descargar [PDF] {EPUB} LA SEGUNDA VIDA DE BREE TANNER
Creators: name: Yi
Publisher: name: Zenodo
Year: 2024

description: LA SEGUNDA VIDA DE BREE TANNER de STEPHENIE MEYER

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Ficha técnica

LA SEGUNDA VIDA DE BREE TANNER

STEPHENIE MEYER

Número de páginas: 240

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788420406268

Editorial: ALFAGUARA

Año de edición: 2010

 

 

 

 

 

Descargar ebooks gratis por isbn LA SEGUNDA VIDA DE BREE TANNER 9788420406268

 

Overview

La segunda vida de Bree Tanner narra la historia de un vampiro creado por Stephenie Meyer para Eclipse, la tercera entrega de la Saga Crepúsculo.La segunda vida de Bree Tanner es la fascinante historia de este vampiro y del lado más oscuro del mundo en el que habita. La novela recrea el nacimiento del nuevo ejército de vampiros que tiene como única misión ir al encuentro de la indefensa Bella Swan y de la indestructible familia Cullen.Bree Tanner no sólo es una figura prominente en el libro de Eclipse, sino que también lo será en la película basada en este volumen de la Saga Crepúsculo, producida por Summit Entertainment.
Induction of hyporesponsiveness to intact foreign protein via retroviral-mediated gene expression: The IgG scaffold is important for induction and maintenance of immune hyporesponsiveness
Creators: name: Tisch, Roland
name: Deng, Edward
name: Melo, Marco
name: Kang, Yubin
name: El-Amine, Moustapha
name: Scott, David W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: IgG molecules can be highly tolerogenic carriers for associated antigens. Previously, we reported that recipients of bone marrow or lipopolysaccharide-stimulated B-cell blasts, both of which were retrovirally gene-transferred with an immunodominant peptide in-frame with the variable region of a murine IgG heavy chain, were rendered profoundly unresponsive to that epitope. To further investigate whether tolerance to larger molecules can be achieved via this approach and whether the IgG scaffold is important for induction and maintenance of immunological tolerance, we engineered two retroviral constructs encoding the cI λ repressor (MBAE-1–102 and MBAE-1–102-IgG) for gene transfer. Our results show that recipients of bone marrow or peripheral B cells, transduced with the MBAE-1–102-IgG recombinant, are hyporesponsive to p1–102. In addition, the self-IgG scaffold enhanced the induction and maintenance of such an immune hyporesponsiveness. Thus, our studies demonstrate that in vivo-expressed IgG heavy chain fusion protein can be processed and presented on the appropriate MHC class II, resulting in hyporesponsiveness to that antigen and offering an additional therapeutic approach to autoimmune diseases.
LA MATERIA DE LAS SOMBRAS leer epub ANTONIO RUNA
Creators: name: Dubois
Publisher: name: Zenodo
Year: 2024

description: LA MATERIA DE LAS SOMBRAS de ANTONIO RUNA

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LA MATERIA DE LAS SOMBRAS

ANTONIO RUNA

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788445016800

Editorial: MINOTAURO

Año de edición: 2024

 

 

 

 

 

Ebook nl descargar gratis LA MATERIA DE LAS SOMBRAS de ANTONIO RUNA 9788445016800

 

Overview

La nueva obra de Antonio Runa (La Órbita de Endor)Un supuesto demonio que adopta la imagen de una señora con piel de crustáceo? Un fantasma artificial que se revela contra sus creadores?Una amiga imaginaria que ha ido pasando de un huésped a otro? Tres entidades del plano más etéreo de la realidad se cruzan en el caso más inaudito del detective de lo paranormal Isaac Zarco, cuyos poderes psíquicos no cesan de atormentarle y amenazan con corromperlo. Un cúmulo de desafíos que pondrán en riesgo no sólo su vida, sino la de todos sus seres queridos.
{epub download} La salope éthique  - Guide pratique pour des relations libres sereines
Creators: name: Sinclair
Publisher: name: Zenodo
Year: 2024

description: La salope éthique - Guide pratique pour des relations libres sereines pan Dossie Easton, Janet W. Hardy

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Caractéristiques

La salope éthique - Guide pratique pour des relations libres sereines

Dossie Easton, Janet W. Hardy

Nb. de pages: 350

Format: Pdf, ePub, MOBI, FB2

ISBN: 9782915635768

Editeur: Tabou

Date de parution: 2013

 

 

 

Derniers eBooks La salope éthique - Guide pratique pour des relations libres sereines en francais PDF PDB 9782915635768 par Dossie Easton, Janet W. Hardy

 

Overview

En 1997, un objet littéraire non identifié en provenance des États-Unis nous percutait de plein fouet : The Ethical Slut de Dossie Easton et Janet W Hardy, autrement dit La Salope éthique…Mais quelle était donc cette créature singulière, cette salope autoproclamée et de plus douée d’un sens éthique ? Dans certains cercles avertis l’ouvrage eut un retentissement considérable. Très rapidement il devint la bible de celles et ceux à qui la perspective de la monogamie-jusqu’à-ce-que-la-mort-nous-sépare semblait un tout petit peu terne. Ainsi La Salope Éthique revendiquait le droit de sortir des sentiers battus. Héritière du libertinage et de l’amour libre, elle faisait l’apologie du "polyamour"…sans pour autant invalider la monogamie choisie après mûres réflexions. "Polyamour ?" Vous voulez dire "polygamie ?" Pas exactement. Pour expliquer le polyamour il suffit de prendre en compte les postulats inébranlables sur lesquels il repose : consentement et consensualité, introspection lucide, limites personnelles claires et précises, respect de ces limites ainsi que de celles d’autrui, communication honnête, désir de garantir le bien-être de l’ensemble des partenaires… et puis fidélité. Eh oui, de même que le concept de "salope abstinente" n’est, comme vous le découvrirez dans cet ouvrage, pas un oxymore, la fidélité fait bel et bien partie intégrante des relations multiples. Car fidélité signifie avant tout respect des engagements pris ! Déconstruisant allègrement les mythes et les fondements de l’Occident en matière d’amours et de sexualités, Dossie Easton et Janet W. Hardy ont mis, dans cet ouvrage mis à jour et adapté à notre culture, leur expérience à notre service pour nous offrir une magnifique boîte à outils relationnelle. Désapprentissage de la jalousie, disputes équitables, conflits constructifs, ruptures sereines, tout en baignant dans une abondance d’amour et d’amitié…tout cela est devenu de l’ordre du possible pour les salopes éthiques. Une salope éthique donc, mais aussi épanouie, en harmonie avec le monde et débordante d’humanité. Un guide de vie qui concerne tout le monde au-delà du sexe, du genre et de la sexualité !
All Sky Modelling Requirements for Bayesian 21 cm Power Spectrum Estimation with BayesEoR
Creators: name: Burba, Jacob
name: Sims, Peter H.
name: Pober, Jonathan C.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present a comprehensive simulation-based study of the BayesEoR code for 21 cm power spectrum recovery when analytically marginalizing over foreground parameters. To account for covariance between the 21 cm signal and contaminating foreground emission, BayesEoR jointly constructs models for both signals within a Bayesian framework. Due to computational constraints, the forward model is constructed using a restricted field-of-view (FoV) in the image domain. When the only EoR contaminants are noise and foregrounds, we demonstrate that BayesEoR can accurately recover the 21 cm power spectrum when the component of sky emission outside this forward-modelled region is downweighted by the beam at the level of the dynamic range between the foreground and 21 cm signals. However, when all-sky foreground emission is included along with a realistic instrument primary beam with sidelobes above this threshold extending to the horizon, the recovered power spectrum is contaminated by unmodelled sky emission outside the restricted FoV model. Expanding the combined cosmological and foreground model to cover the whole sky is computationally prohibitive. To address this, we present a modified version of BayesEoR that allows for an all-sky foreground model, while the modelled 21 cm signal remains only within the primary FoV of the telescope. With this modification, it will be feasible to run an all-sky BayesEoR analysis on a sizeable compute cluster. We also discuss several future directions for further reducing the need to model all-sky foregrounds, including wide-field foreground subtraction, an image-domain likelihood utilizing a tapering function, and instrument primary beam design.
description: 14 pages, 8 figures
Abolition of male sexual behaviors in mice lacking estrogen receptors alpha and beta (alpha beta ERKO)
Creators: name: Gustafsson, Jan Åke
name: Chester, April E.
name: Walker, Vickie R.
name: Ogawa, Sonoko
name: Korach, Kenneth S.
name: Smithies, Oliver
name: Hewitt, Sylvia Curtis
name: Pfaff, Donald W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: Male mice with a knockout of the estrogen receptor (ER)-α gene, a ligand-activated transcription factor, showed reduced levels of intromissions and no ejaculations whereas simple mounting behavior was not affected. In contrast, all components of sexual behaviors were intact in male mice lacking the novel ER-β gene. Here we measure the extent of phenotype in mice that lack both ER-α and ER-β genes (αβERKO). αβERKO male mice did not show any components of sexual behaviors, including simple mounting behavior. Nor did they show ultrasonic vocalizations during behavioral tests with receptive female mice. On the other hand, reduced aggressive behaviors of αβERKO mice mimicked those of single knockout mice of ER-α gene (αERKO). They showed reduced levels of lunge and bite aggression, but rarely showed offensive attacks. Thus, either one of the ERs is sufficient for the expression of simple mounting in male mice, indicating a redundancy in function. Offensive attacks, on the other hand, depend specifically on the ER-α gene. Different patterns of natural behaviors require different patterns of functions by ER genes.
Lumpings of Algebraic Markov Chains arise from Subquotients
Creators: name: Pang, C. Y. Amy
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: Probability (math.PR)
subject: FOS: Mathematics

description: A function on the state space of a Markov chain is a "lumping" if observing only the function values gives a Markov chain. We give very general conditions for lumpings of a large class of algebraically-defined Markov chains, which include random walks on groups and other common constructions. We specialise these criteria to the case of descent operator chains from combinatorial Hopf algebras, and, as an example, construct a "top-to-random-with-standardisation" chain on permutations that lumps to a popular restriction-then-induction chain on partitions, using the fact that the algebra of symmetric functions is a subquotient of the Malvenuto-Reutenauer algebra.
description: 36 pages. Minor update from v2 after peer-review, with numerical sectioning as in the published version. (v2 was majorly reworked from v1, with new results in sections 3.5/II.D and 3.6/II.E, and new examples in Part I/Section 2.)
[Pdf/ePub/Mobi] EL CIELO ES AZUL, LA TIERRA BLANCA - HIROMI KAWAKAMI descargar ebook gratis
Creators: name: Smith
Publisher: name: Zenodo
Year: 2024

description: EL CIELO ES AZUL, LA TIERRA BLANCA de HIROMI KAWAKAMI

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EL CIELO ES AZUL, LA TIERRA BLANCA

HIROMI KAWAKAMI

Número de páginas: 216

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788466343824

Editorial: DEBOLSILLO (PUNTO DE LECTURA)

Año de edición: 2018

 

 

 

 

 

Descargar libros gratis en línea EL CIELO ES AZUL, LA TIERRA BLANCA en español

 

Overview

La gran novela japonesa que ha marcado un hito en la literatura contemporánea, una historia de amor inolvidable.
[PDF/Kindle] Containment by Caryn Lix
Creators: name: Hollandsworth
Publisher: name: Zenodo
Year: 2024

description: Containment by Caryn Lix

 

 

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Containment

Caryn Lix

Page: 496

Format: pdf, ePub, mobi, fb2

ISBN: 9781534405387

Publisher: Simon Pulse

 

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Supplementary Information file from Light-controlled growth of DNA organelles in synthetic cells
Creators: name: Agarwal, Siddharth
name: Dizani, Mahdi
name: Osmanovic, Dino
name: Franco, Elisa
Publisher: name: The Royal Society
Year: 2023
Subjects: subject: Biophysics
classificationCode: 90301
subject: Biomaterials
classificationCode: 100799
subject: Nanotechnology not elsewhere classified

description: This file includes additional experiments, simulations, and methods.
Topology Control of wireless sensor network using Quantum Inspired Genetic algorithm
Creators: name: Ullah, Sajid
name: Wahid, Mussarat
Publisher: name: arXiv
Year: 2015
Subjects: subject: Neural and Evolutionary Computing (cs.NE)
subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: In this work, an evolving Linked Quantum register has been introduced, which are group vector of binary pair of genes, which in its local proximity represent those nodes that will have high connectivity and keep the energy consumption at low, and which are taken into account for topology control. The register works in higher dimension. Here order-2 Quantum inspired genetic algorithm has been used and also higher order can be used to achieve greater versatility in topology control of nodes. Numerical result has been obtained, analysis is done as how the result has previously been obtained with Quantum genetic algorithm and results are compared too. For future work, factor is hinted which would exploit the algorithm to work in more computational intensive problem.
description: 4 Figures/6 pages
Partitioning of Thy-1, GM1, and cross-linked phospholipid analogs into lipid rafts reconstituted in supported model membrane monolayers
Creators: name: Volovyk, Zoya N.
name: Levi, Moshe
name: Jacobson, Ken
name: Dietrich, Christian
name: Thompson, Nancy L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: As shown earlier, raft-like domains resembling those thought to be present in natural cell membranes can be formed in supported planar lipid monolayers. These liquid-ordered domains coexist with a liquid-disordered phase and form in monolayers prepared both from synthetic lipid mixtures and lipid extracts of the brush border membrane of mouse kidney cells. The domains are detergent-resistant and are highly enriched in the glycosphingolipid GM1. In this work, the properties of these raft-like domains are further explored and compared with properties thought to be central to raft function in plasma membranes. First, it is shown that domain formation and disruption critically depends on the cholesterol density and can be controlled reversibly by treating the monolayers with the cholesterol-sequestering reagent methyl-β-cyclodextrin. Second, the glycosylphosphatidylinositol-anchored cell-surface protein Thy-1 significantly partitions into the raft-like domains. The extent of this partitioning is reduced when the monolayers contain GM1, indicating that different molecules can compete for domain occupation. Third, the partitioning of a saturated phospholipid analog into the raft phase is dramatically increased (15% to 65%) after cross-linking with antibodies, whereas the distribution of a doubly unsaturated phospholipid analog is not significantly affected by cross-linking (≈10%). This result demonstrates that cross-linking, a process known to be important for certain cell-signaling processes, can selectively translocate molecules to liquid-ordered domains.
The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction
Creators: name: Cohen, Christopher J.
name: Hsieh, Jer Tsong
name: Okegawa, Takatsugu
name: Bergelson, Jeffrey M.
name: Pickles, Raymond J.
name: Shieh, Joseph T.C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: The coxsackievirus and adenovirus receptor (CAR) mediates viral attachment and infection, but its physiologic functions have not been described. In nonpolarized cells, CAR localized to homotypic intercellular contacts, mediated homotypic cell aggregation, and recruited the tight junction protein ZO-1 to sites of cell–cell contact. In polarized epithelial cells, CAR and ZO-1 colocalized to tight junctions and could be coprecipitated from cell lysates. CAR expression led to reduced passage of macromolecules and ions across cell monolayers, and soluble CAR inhibited the formation of functional tight junctions. Virus entry into polarized epithelium required disruption of tight junctions. These results indicate that CAR is a component of the tight junction and of the functional barrier to paracellular solute movement. Sequestration of CAR in tight junctions may limit virus infection across epithelial surfaces.
Reversible stepwise condensation polymerization with cyclization: strictly alternating co-polymerization and homopolymerization based upon two orthogonal reactions
Creators: name: Lang, Michael
name: Kumar, Kiran Suresh
Publisher: name: arXiv
Year: 2023
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: In a preceding work [M. Lang, K. Kumar, A simple and general approach for reversible condensation polymerization with cyclization, Macromolecules 54 (2021) 7021], we have introduced a simple recursive scheme that allows to treat stepwise linear reversible polymerizations of any kind with cyclization. This approach is used to discuss the polymerization of linear Gaussian strands (LGS) with two different reactive groups $A$ and $B$ on either chain end that participate in two orthogonal reactions and the strictly alternating copolymerization of LGS that carry $A$ reactive groups with LGS equipped with type $B$ reactive groups. The former of these cases has not been discussed theoretically in literature, the latter only regarding some special cases. We provide either analytical expressions or exact numerical solutions for the general cases with and without cyclization. Weight distributions, averages, polydispersity, and the weight fractions of cyclic and linear species are computed. All numerical solutions were tested by Monte-Carlo simulations.
(3186) Eleanor Smith
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
The human decatenation checkpoint
Creators: name: Kaufmann, William K.
name: Graves, Paul R.
name: Piwnica-Worms, Helen
name: Downes, C. Stephen
name: Paules, Richard S.
name: Zhao, Hui
name: Cistulli, Cheryl A.
name: Deming, Paula B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Chromatid catenation is actively monitored in human cells, with progression from G2 to mitosis being inhibited when chromatids are insufficiently decatenated. Mitotic delay was quantified in normal and checkpoint-deficient human cells during treatment with ICRF-193, a topoisomerase II catalytic inhibitor that prevents chromatid decatenation without producing topoisomerase-associated DNA strand breaks. Ataxia telangiectasia (A-T) cells, defective in DNA damage checkpoints, showed normal mitotic delay when treated with ICRF-193. The mitotic delay in response to ICRF-193 was ablated in human fibroblasts expressing an ataxia telangiectasia mutated- and rad3-related (ATR) kinase-inactive ATR allele (ATRki). BRCA1-mutant HCC1937 cells also displayed a defect in ICRF-193-induced mitotic delay, which was corrected by expression of wild-type BRCA1. Phosphorylations of hCds1 or Chk1 and inhibition of Cdk1 kinase activity, which are elements of checkpoints associated with DNA damage or replication, did not occur during ICRF-193-induced mitotic delay. Over-expression of cyclin B1 containing a dominant nuclear localization signal, and inhibition of Crm1-mediated nuclear export, reversed ICRF-193-induced mitotic delay. In combination, these results imply that ATR and BRCA1 enforce the decatenation G2 checkpoint, which may act to exclude cyclin B1/Cdk1 complexes from the nucleus. Moreover, induction of ATRki produced a 10-fold increase in chromosomal aberrations, further emphasizing the vital role for ATR in genetic stability.
Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney
Creators: name: Griffiths, Robert
name: Ruiz, Phillip
name: Kumar, Anil P.
name: Coffman, Thomas M.
name: Smithies, Oliver
name: Kim, Hyung Suk
name: Gurley, Susan B.
name: Herrera, Maria J.
name: Le, Thu H.
name: Crowley, Steven D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Essential hypertension is a common disease, yet its pathogenesis is not well understood. Altered control of sodium excretion in the kidney may be a key causative feature, but this has been difficult to test experimentally, and recent studies have challenged this hypothesis. Based on the critical role of the renin-angiotensin system (RAS) and the type I (AT1) angiotensin receptor in essential hypertension, we developed an experimental model to separate AT1 receptor pools in the kidney from those in all other tissues. Although actions of the RAS in a variety of target organs have the potential to promote high blood pressure and end-organ damage, we show here that angiotensin II causes hypertension primarily through effects on AT1 receptors in the kidney. We find that renal AT1 receptors are absolutely required for the development of angiotensin II-dependent hypertension and cardiac hypertrophy. When AT1 receptors are eliminated from the kidney, the residual repertoire of systemic, extrarenal AT1 receptors is not sufficient to induce hypertension or cardiac hypertrophy. Our findings demonstrate the critical role of the kidney in the pathogenesis of hypertension and its cardiovascular complications. Further, they suggest that the major mechanism of action of RAS inhibitors in hypertension is attenuation of angiotensin II effects in the kidney.
Hybrid neutron stars with the Dyson-Schwinger quark model and various quark-gluon vertices
Creators: name: Chen, H.
name: Wei, J. -B.
name: Baldo, M.
name: Burgio, G. F.
name: Schulze, H. -J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We study cold dense quark matter and hybrid neutron stars with a Dyson-Schwinger quark model and various choices of the quark-gluon vertex. We obtain the equation of state of quark matter in beta equilibrium and investigate the hadron-quark phase transition in combination with a hadronic equation of state derived within the Brueckner-Hartree-Fock many-body theory. Comparing with the results for quark matter with the rainbow approximation, the Ball-Chiu ansatz and the 1BC ansatz for the quark-gluon vertex lead to a reduction of the effective interaction at finite chemical potential, qualitatively similar to the effect of our gluon propagator. We find that the phase transition and the equation of state of the quark or mixed phase and consequently the resulting hybrid star mass and radius depend mainly on a global reduction of the effective interaction due to effects of both the quark-gluon vertex and gluon propagator, but are not sensitive to the vertex ansatz.
description: 6 pages, 5 figures
Structural basis for nucleotide exchange on G i subunits and receptor coupling specificity
Creators: name: Siderovski, David P.
name: Johnston, Christopher A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Heterotrimeric G proteins are molecular switches that relay information intracellularly in response to various extracellular signals. How ligand-activated G protein-coupled receptors act at a distance to exert exchange activity on the Galpha nucleotide binding pocket is poorly understood. Here we describe the synergistic action of two peptides: one from the third intracellular loop of the D2 dopamine receptor (D2N), and a second, Galpha.GDP-binding peptide (KB-752) that mimics the proposed role of Gbetagamma in receptor-promoted nucleotide exchange. The structure of both peptides in complex with Galpha(i1) suggests that conformational changes in the beta3/alpha2 loop and beta6 strand act in concert for efficient nucleotide exchange. Two key residues in the alpha4 helix were found to define a receptor/Galpha(i) coupling specificity determinant.