cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Trans -Golgi Network and Endosome Dynamics Connect Ceramide Homeostasis with Regulation of the Unfolded Protein Response and TOR Signaling in Yeast
Creators: name: Wenk, Markus R.
name: Brost, Renee L.
name: Boone, Charles
name: Guan, Xueli
name: Mousley, Carl J.
name: Ile, Kristina E.
name: Tyeryar, Kimberly
name: Bankaitis, Vytas A.
name: Schaaf, Gabriel
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Synthetic genetic array analyses identify powerful genetic interactions between a thermosensitive allele (sec14-1ts) of the structural gene for the major yeast phosphatidylinositol transfer protein (SEC14) and a structural gene deletion allele (tlg2Δ) for the Tlg2 target membrane-soluble N-ethylmaleimide-sensitive factor attachment protein receptor. The data further demonstrate Sec14 is required for proper trans-Golgi network (TGN)/endosomal dynamics in yeast. Paradoxically, combinatorial depletion of Sec14 and Tlg2 activities elicits trafficking defects from the endoplasmic reticulum, and these defects are accompanied by compromise of the unfolded protein response (UPR). UPR failure occurs downstream of Hac1 mRNA splicing, and it is further accompanied by defects in TOR signaling. The data link TGN/endosomal dynamics with ceramide homeostasis, UPR activity, and TOR signaling in yeast, and they identify the Sit4 protein phosphatase as a primary conduit through which ceramides link to the UPR. We suggest combinatorial Sec14/Tlg2 dysfunction evokes inappropriate turnover of complex sphingolipids in endosomes. One result of this turnover is potentiation of ceramide-activated phosphatase-mediated down-regulation of the UPR. These results provide new insight into Sec14 function, and they emphasize the TGN/endosomal system as a central hub for homeostatic regulation in eukaryotes.
Turbidity spectrometry / IRIS pitch presentation
Creators: name: Bolton, James
Publisher: name: Zenodo
Year: 2023
Subjects: Process Analytical Technologies
PAT
Characterisation technique
industrial nanoparticle production
nanomaterials
nanoparticles

description: Pitch presentation of the Turbidity spectrometry (TUS), the Process Analytical Technology (PAT) developed by IRIS Technology Solutions S.L. within the NanoPAT project. TUS is an online real-time characterisation solution for nanoparticle production processes.
Additional file 1 of Effectiveness of WhatsApp based debunking reminders on follow-up visit attendance for individuals with hypertension: a randomized controlled trial in India
Creators: name: Favaretti, Caterina
name: Subramonia Pillai, Vasanthi
name: Murthy, Seema
name: Chandrasekar, Adithi
name: Yan, Shirley D.
name: Sulaiman, Huma
name: Gautam, Atul
name: Kaur, Baljit
name: Ali, Mohammed K.
name: McConnell, Margaret
name: Sudharsanan, Nikkil
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Supplementary Material 1
OptoFluidic Force induction / BRAVE pitch presentation
Creators: name: Hill, Christian
Publisher: name: Zenodo
Year: 2023
Subjects: Process Analytical Technologies
PAT
characterisation technique
industrial nanoparticle production
nanomaterials
nanoparticles

description: Pitch presentation of the OptoFluidic Force induction (OF2i), the Process Analytical Technology (PAT) developed by BRAVE Analytics GmbH within the NanoPAT project. PDW is an inline real-time characterisation solution for nanoparticle production processes.
ЛЕТОПИСЬ ПРИРОДЫ КАК СИСТЕМАТИЗИРОВАННЫЙ РЕСУРС ДАННЫХ О БИОРАЗНООБРАЗИИ РОССИИ И СОПРЕДЕЛЬНЫХ СТРАН
Creators: name: Ю.А., Буйволов
name: Н.В., Иванова
name: Е.П., Быкова
name: Е., Мейке
Publisher: name: Zenodo
Year: 2020
Subjects: GBIF
nature protected areas
Eurasian chronicle of nature
Prioksko-Terrasnyi biosphere reserve

description: Our presentation is devoted to biodiversity data mobilization collected in nature protected areas of the former USSR according to the scientific program Chronicle of nature. Most of the Chronicles still notdigitized. But during the Eurasian Chronicle of Nature and GBIF projects implementation, 500 000+ records were digitized, and mobilized via Zenodo and GBIF.
(401605) [Unknown] Ritchie
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
MORPHOLOGICAL AND SEMANTIC ASPECTS OF EPONYMS IN ENGLISH LANGUAGE
Creators: name: Azimova, Anisa
Publisher: name: Zenodo
Year: 2023

description: The term eponym has been used in literature to denote different linguistic phenomena: (1) a lexeme derived from a personal name; (2) the name from which such a lexeme is derived; (3) the person whose name is thus used; (4) any proper noun that has become a common noun, esp. brand names, e.g. xerox, Kleenex (sometimes also called 'proprietary eponyms') (cf. McArthur 1992). Lexemes treated as eponyms in this paper are those that have been formed from names of people, real of fictitious, by any of the word-formation processes.
Using Bcr-Abl to Examine Mechanisms by Which Abl Kinase Regulates Morphogenesis in Drosophila
Creators: name: Koontz, Laura M.
name: Fox, Donald T.
name: Stevens, Traci L.
name: Rogers, Edward M.
name: Peifer, Mark
name: Artabazon, Nicholas B.
name: Nowotarski, Stephanie H.
name: Homem, Catarina C.F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Signaling by the nonreceptor tyrosine kinase Abelson (Abl) plays key roles in normal development, whereas its inappropriate activation helps trigger the development of several forms of leukemia. Abl is best known for its roles in axon guidance, but Abl and its relatives also help regulate embryonic morphogenesis in epithelial tissues. Here, we explore the role of regulation of Abl kinase activity during development. We first compare the subcellular localization of Abl protein and of active Abl, by using a phosphospecific antibody, providing a catalog of places where Abl is activated. Next, we explore the consequences for morphogenesis of overexpressing wild-type Abl or expressing the activated form found in leukemia, Bcr-Abl. We find dose-dependent effects of elevating Abl activity on morphogenetic movements such as head involution and dorsal closure, on cell shape changes, on cell protrusive behavior, and on the organization of the actin cytoskeleton. Most of the effects of Abl activation parallel those caused by reduction in function of its target Enabled. Abl activation leads to changes in Enabled phosphorylation and localization, suggesting a mechanism of action. These data provide new insight into how regulated Abl activity helps direct normal development and into possible biological functions of Bcr-Abl.
Effective fermion kinematics from a modified quantum gravity
Creators: name: Alexandre, J.
name: Leite, J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider a classical fermion and a classical scalar, propagating on two different kinds of 4-dimensional diffeomorphism breaking gravity backgrounds, and we derive the one-loop effective dispersion relation for matter, after integrating out gravitons. One gravity model involves quadratic divergences at one-loop, as in Einstein gravity, and the other model is the $z=3$ non-projectable Horava-Lifshitz gravity, which involves logarithmic divergences only. Although these two models behave differently in the UV, the IR phenomenology for matter fields is comparable: {\it(i)} for generic values for the parameters, both models identify $10^{10}$ GeV as the typical characteristic scale above which they are not consistent with current upper bounds on Lorentz symmetry violation; {\it(ii)} on the other hand there is always, for both models, a fine-tuning of parameters which allows the cancellation of the indicator for Lorentz symmetry violation.
description: 23 pages, comments added
Coilin Is Essential for Cajal Body Organization in Drosophila melanogaster
Creators: name: Wu, Zhenǵan
name: Deryusheva, Svetlana
name: Nizami, Zehra
name: Beumer, Kelly J.
name: Carroll, Dana
name: Gao, Hongjuan
name: Liu, Ji Long
name: Rajendra, T. K.
name: Matera, A. Gregory
name: Gall, Joseph G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Cajal bodies (CBs) are nuclear organelles that occur in a variety of organisms, including vertebrates, insects, and plants. They are most often identified with antibodies against the marker protein coilin. Because the amino acid sequence of coilin is not strongly conserved evolutionarily, coilin orthologues have been difficult to recognize by homology search. Here, we report the identification of Drosophila melanogaster coilin and describe its distribution in tissues of the fly. Surprisingly, we found coilin not only in CBs but also in histone locus bodies (HLBs), calling into question the use of coilin as an exclusive marker for CBs. We analyzed two null mutants in the coilin gene and a piggyBac insertion mutant, which leads to specific loss of coilin from the germline. All three mutants are homozygous viable and fertile. Cells that lack coilin also lack distinct foci of other CB markers, including fibrillarin, the survival motor neuron (SMN) protein, U2 small nuclear RNA (snRNA), U5 snRNA, and the small CB-specific (sca) RNA U85. However, HLBs are not obviously affected in coilin-null flies. Thus, coilin is required for normal CB organization in Drosophila but is not essential for viability or production of functional gametes.
Condensin Regulates the Stiffness of Vertebrate Centromeres
Creators: name: Hudson, Damien F.
name: Vagnarelli, Paola
name: Dong, Yimin
name: McEwen, Bruce F.
name: Gatlin, Jesse C.
name: Cameron, Lisa
name: Farr, Christine F.
name: Ribeiro, Susana A.
name: Salmon, Edward D.
name: Joglekar, Ajit
name: Earnshaw, William C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: When chromosomes are aligned and bioriented at metaphase, the elastic stretch of centromeric chromatin opposes pulling forces exerted on sister kinetochores by the mitotic spindle. Here we show that condensin ATPase activity is an important regulator of centromere stiffness and function. Condensin depletion decreases the stiffness of centromeric chromatin by 50% when pulling forces are applied to kinetochores. However, condensin is dispensable for the normal level of compaction (rest length) of centromeres, which probably depends on other factors that control higher-order chromatin folding. Kinetochores also do not require condensin for their structure or motility. Loss of stiffness caused by condensin-depletion produces abnormal uncoordinated sister kinetochore movements, leads to an increase in Mad2(+) kinetochores near the metaphase plate and delays anaphase onset.
(401601) John Edward
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 2 of Effectiveness of WhatsApp based debunking reminders on follow-up visit attendance for individuals with hypertension: a randomized controlled trial in India
Creators: name: Favaretti, Caterina
name: Subramonia Pillai, Vasanthi
name: Murthy, Seema
name: Chandrasekar, Adithi
name: Yan, Shirley D.
name: Sulaiman, Huma
name: Gautam, Atul
name: Kaur, Baljit
name: Ali, Mohammed K.
name: McConnell, Margaret
name: Sudharsanan, Nikkil
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Supplementary Material 2
Photon Density Wave Spectroscopy / PDWA pitch presentation
Creators: name: Krause, Anika
name: Haas, Roland
Publisher: name: Zenodo
Year: 2023
Subjects: Process Analytical Technologies
PAT
characterisation technique
industrial nanoparticle production
nanomaterials
nanoparticles

description: Pitch presentation of the Photon Density Wave Spectroscopy (PDW), the Process Analytical Technology (PAT) developed by PDW Analytics GmbH within the NanoPAT project. PDW is an online real-time characterisation solution for nanoparticle production processes.
Exploring the Roles of Diaphanous and Enabled Activity in Shaping the Balance between Filopodia and Lamellipodia
Creators: name: Peifer, Mark
name: Homem, Catarina C.F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: During migration cell protrusions power cell extension and sample the environment. Different cells produce different protrusions, from keratocytes dominated by lamellipodia, to growth cones combining filopodia and lamellipodia, to dendritic spines. One key challenge is to determine how the toolkit of actin regulators are coordinated to generate these diverse protrusive arrays. Here we use Drosophila leading-edge (LE) cells to explore how Diaphanous (Dia)-related formins and Ena/VASP proteins cooperate in this process. We first dissect the Dia regulatory region, revealing novel roles for the GTPase-binding and FH3 domains in cortical localization, filopodial initiation, and lengthening. Second, we provide evidence that activating Dia mobilizes Ena from storage places near the LE to act at the LE. Further, Dia and Ena coIP and can recruit one another to new locations, suggesting cooperation is key to their mechanisms of action. Third, we directly explore the functional relationship between Dia and Ena, varying their levels and activity separately in the same cell type. Surprisingly, although each is sufficient to induce filopodia, together they induce lamellipodia. Our data suggest they work together in a complex and nonadditive way, with the ratio between active Dia and Ena being one factor that modulates the balance between filopodia and lamellipodia.
(401602) Maggie Edward
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Function and Assembly of DNA Looping, Clustering, and Microtubule Attachment Complexes within a Eukaryotic Kinetochore
Creators: name: Bloom, Kerry
name: Yeh, Elaine
name: Haase, Julian
name: Anderson, Marybeth
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The kinetochore is a complex protein–DNA assembly that provides the mechanical linkage between microtubules and the centromere DNA of each chromosome. Centromere DNA in all eukaryotes is wrapped around a unique nucleosome that contains the histone H3 variant CENP-A (Cse4p in Saccharomyces cerevisiae). Here, we report that the inner kinetochore complex (CBF3) is required for pericentric DNA looping at the Cse4p-containing nucleosome. DNA within the pericentric loop occupies a spatially confined area that is radially displaced from the interpolar central spindle. Microtubule-binding kinetochore complexes are not involved in pericentric DNA looping but are required for the geometric organization of DNA loops around the spindle microtubules in metaphase. Thus, the mitotic segregation apparatus is a composite structure composed of kinetochore and interpolar microtubules, the kinetochore, and organized pericentric DNA loops. The linkage of microtubule-binding to centromere DNA-looping complexes positions the pericentric chromatin loops and stabilizes the dynamic properties of individual kinetochore complexes in mitosis.
Functional Overlap of Microtubule Assembly Factors in Chromatin-Promoted Spindle Assembly
Creators: name: Maresca, Thomas J.
name: Salmon, Edward D.
name: Gatlin, Jesse C.
name: Mitchison, Timothy J.
name: Groen, Aaron C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Distinct pathways from centrosomes and chromatin are thought to contribute in parallel to microtubule nucleation and stabilization during animal cell mitotic spindle assembly, but their full mechanisms are not known. We investigated the function of three proposed nucleation/stabilization factors, TPX2, γ-tubulin and XMAP215, in chromatin-promoted assembly of anastral spindles in Xenopus laevis egg extract. In addition to conventional depletion-add back experiments, we tested whether factors could substitute for each other, indicative of functional redundancy. All three factors were required for microtubule polymerization and bipolar spindle assembly around chromatin beads. Depletion of TPX2 was partially rescued by the addition of excess XMAP215 or EB1, or inhibiting MCAK (a Kinesin-13). Depletion of either γ-tubulin or XMAP215 was partially rescued by adding back XMAP215, but not by adding any of the other factors. These data reveal functional redundancy between specific assembly factors in the chromatin pathway, suggesting individual proteins or pathways commonly viewed to be essential may not have entirely unique functions.
The high molecular weight complex formed by the plant immune receptor Rx does not contain host protein RanGAP2
Creators: name: Contreras, Mauricio P.
name: Kamoun, Sophien
Publisher: name: Zenodo
Year: 2022
Subjects: Plant Immunity, NLR, plant virus, Rx, RanGAP2, Native PAGE

description: This Technical Note complements our paper on the activation of sensor-helper paired NLRs in the solanaceous NRC network (Contreras et al, 2022). The NLR protein Rx (confers virus resistance) constitutively forms a high molecular weight complex that is independent of its downstream helpers of the NLR required for cell death (NRC) family. Here, we show that RanGAP2, a previously identified interactor of Rx does not form part of this immune complex under our assay conditions. The exact nature of the Rx high molecular weight complex therefore remains elusive.
(401603) John Ritchie
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 1 of Diarrhoeagenic Escherichia coli associated with childhood diarrhoea in Osun state, Nigeria
Creators: name: Olayinka, Ademola A.
name: Oginni-Falajiki, Ibukunoluwa O.
name: Okeke, Iruka N.
name: Aboderin, Aaron O.
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Supplementary Material 1
QCD phase transition at real chemical potential with canonical approach
Creators: name: Nakamura, Atsushi
name: Oka, Shotaro
name: Taniguchi, Yusuke
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the finite density phase transition in the lattice QCD at real chemical potential. We adopt canonical approach and the canonical partition function is constructed for Nf=2 QCD. After derivation of the canonical partition function we calculate observables like the pressure, the quark number density, its second cumulant and the chiral condensate as a function of the real chemical potential. We covered a wide range of temperature region starting from the confining low to the deconfining high temperature. We observe signals for the deconfinement and the chiral restoration phase transition at real chemical potential below Tc starting from the confining phase.
description: 15 pages, 20 figures
Construction of 4d SYM compactified on open Riemann surfaces by the superfield formalism
Creators: name: Nagasaki, Koichi
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: By compactifying gauge theories on a lower dimensional manifold, we often find many interesting relationships between a geometry and a supersymmetric quantum field theory. In this paper we consider conformal field theories obtained from twisted compactification on a Riemann surface with a boundary. Various kinds of supersymmetric boundary conditions are exchanged under S-duality. To consider these transformations one need to take into account boundary degrees of freedom. So we study how the degrees of freedom can be added at the boundary of the Riemann surface. In this paper I show that this introduction of the boundary fields can be done preserving supersymmetry by means of 2-dimensional superfields.
description: 14 pages, some typos corrected and introduction is rewritten, the title and abstract were changed
Gemin3 Is an Essential Gene Required for Larval Motor Function and Pupation in Drosophila
Creators: name: Shpargel, Karl B.
name: Matera, A. Gregory
name: Praveen, Kavita
name: Rajendra, T. K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The assembly of metazoan Sm-class small nuclear ribonucleoproteins (snRNPs) is an elaborate, step-wise process that takes place in multiple subcellular compartments. The initial steps, including formation of the core RNP, are mediated by the survival motor neuron (SMN) protein complex. Loss-of-function mutations in human SMN1 result in a neuromuscular disease called spinal muscular atrophy. The SMN complex is comprised of SMN and a number of tightly associated proteins, collectively called Gemins. In this report, we identify and characterize the fruitfly ortholog of the DEAD box protein, Gemin3. Drosophila Gemin3 (dGem3) colocalizes and interacts with dSMN in vitro and in vivo. RNA interference for dGem3 codepletes dSMN and inhibits efficient Sm core assembly in vitro. Transposon insertion mutations in Gemin3 are larval lethals and also codeplete dSMN. Transgenic overexpression of dGem3 rescues lethality, but overexpression of dSMN does not, indicating that loss of dSMN is not the primary cause of death. Gemin3 mutant larvae exhibit motor defects similar to previously characterized Smn alleles. Remarkably, appreciable numbers of Gemin3 mutants (along with one previously undescribed Smn allele) survive as larvae for several weeks without pupating. Our results demonstrate the conservation of Gemin3 protein function in metazoan snRNP assembly and reveal that loss of either Smn or Gemin3 can contribute to neuromuscular dysfunction.
(401600) Margaret [Edward]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
MHD Waves in the coronal holes
Creators: name: Banerjee, D.
name: Prasad, S. Krishna
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Coronal holes are the dark patches in the solar corona associated with relatively cool, less dense plasma and unipolar fields. The fast component of the solar wind emanates from these regions. Several observations reveal the presence of magnetohydrodynamic (MHD) waves in coronal holes which are believed to play a key role in the acceleration of fast solar wind. The recent advent of high-resolution instruments had brought us many new insights on the properties of MHD waves in coronal holes which are reviewed in this article. The advances made in the identification of compressive slow MHD waves in both polar and equatorial coronal holes, their possible connection with the recently discovered high- speed quasi-periodic upflows, their dissipation, and the detection of damping in Alfven waves from the spectral line width variation are discussed in particular.
description: 11 pages, 5 figures. Chapter in AGU Monograph (in press), Review article
Mechanisms for Rescue of Correctable Folding Defects in CFTR F508
Creators: name: Cyr, Douglas M.
name: Rosser, Meredith F.N.
name: Hong, Yu Ren
name: Naren, Anjaparavanda P.
name: Grove, Diane E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Premature degradation of CFTRΔF508 causes cystic fibrosis (CF). CFTRΔF508 folding defects are conditional and folding correctors are being developed as CF therapeutics. How the cellular environment impacts CFTRΔF508 folding efficiency and the identity of CFTRΔF508's correctable folding defects is unclear. We report that inactivation of the RMA1 or CHIP ubiquitin ligase permits a pool of CFTRΔF508 to escape the endoplasmic reticulum. Combined RMA1 or CHIP inactivation and Corr-4a treatment enhanced CFTRΔF508 folding to 3–7-fold greater levels than those elicited by Corr-4a. Some, but not all, folding defects in CFTRΔF508 are correctable. CHIP and RMA1 recognize different regions of CFTR and a large pool of nascent CFTRΔF508 is ubiquitinated by RMA1 before Corr-4a action. RMA1 recognizes defects in CFTRΔF508 related to misassembly of a complex that contains MSD1, NBD1, and the R-domain. Corr-4a acts on CFTRΔF508 after MSD2 synthesis and was ineffective at rescue of ΔF508 dependent folding defects in amino-terminal regions. In contrast, misfolding caused by the rare CF-causing mutation V232D in MSD1 was highly correctable by Corr-4a. Overall, correction of folding defects recognized by RMA1 and/or global modulation of ER quality control has the potential to increase CFTRΔF508 folding and provide a therapeutic approach for CF.
title: Soft tissue tumors and tumorlike lesions of the hand and wrist: a systematic imaging approach
Creators: name: Ruiz De Castañeda Zamora, Cecilia
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Musculoskeletal soft tissue
subject: Conventional radiography
subject: MR
subject: Ultrasound
subject: Education
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: The aims of this educational poster are: To review the spectrum of soft tissue tumors of the hand and illustrate the typical and atypical imaging features. To describe soft tissue tumor mimics of the hand and wrist. To develop a simplified...
title: Interobserver agreement between an expert radiologist and a non-expert radiology when it comes to IPAF specific signs
Creators: name: Tello Lasheras, María
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Lung
subject: Thorax
subject: CT
subject: CT-High Resolution
subject: Comparative studies
subject: Education
subject: Connective tissue disorders
subject: Image verification
subject: Tissue characterisation

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: - To review the signs proposed as characteristic of interstitial lung disease (ILD) associated with connective tissue disease (CTD): anterior upper lobe sign, straight-edge sign, and exuberant honeycombing sign.- To describe the frequency of these...
Additional file 1 of Perspectives on virtual interviews and emerging technologies integration in family medicine residency programs: a cross-sectional survey study
Creators: name: Tolentino, Raymond
name: Rodriguez, Charo
name: Hersson-Edery, Fanny
name: Lane, Julie
name: Abbasgholizadeh Rahimi, Samira
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary Material 1
title: Breast implants: An overview
Creators: name: Cano Mateos, Fátima
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Breast
subject: Mammography
subject: MR
subject: Ultrasound
subject: Diagnostic procedure
subject: Prostheses

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: - Review the various types of breast implants and their normal appearance in different imaging modalities - Describe complications associated with breast implants and how to recognize them in diagnostic imaging...
Generation of semigroups for vector-valued pseudodifferential operators on the torus
Creators: name: Martinez, Bienvenido Barraza
name: Denk, Robert
name: Monzon, Jairo Hernandez
name: Nau, Tobias
Publisher: name: arXiv
Year: 2015
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35S05, 47D06, 35R20

description: We consider toroidal pseudodifferential operators with operator-valued symbols, their mapping properties and the generation of analytic semigroups on vector-valued Besov and Sobolev spaces. We show that a parabolic toroiodal pseudodifferential operator generates an analytic semigroup both on Banach space-valued Besov spaces and on Banach space-valued Sobolev spaces. Here, no condition on the Banach space is imposed. For the proof of the Sobolev space result, we establish a uniform estimate on the kernel which is given as an infinite parameter-dependent sum. An application to abstract non-autonomous periodic pseudodifferential Cauchy problems gives the existence and uniqueness of classical solutions for such problems.
Mitochondrial Reactive Oxygen Species Mediate GPCR-induced TACE/ADAM17-dependent Transforming Growth Factor-  Shedding
Creators: name: Russell, William E.
name: Lee, David C.
name: Myers, Timothy J.
name: Higashiyama, Shigeki
name: Stevenson, Mary
name: Sunnarborg, Susan Wohler
name: Brennaman, Leann H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Epidermal growth factor receptor (EGFR) activation by GPCRs regulates many important biological processes. ADAM metalloprotease activity has been implicated as a key step in transactivation, yet the regulatory mechanisms are not fully understood. Here, we investigate the regulation of transforming growth factor-α (TGF-α) shedding by reactive oxygen species (ROS) through the ATP-dependent activation of the P2Y family of GPCRs. We report that ATP stimulates TGF-α proteolysis with concomitant EGFR activation and that this process requires TACE/ADAM17 activity in both murine fibroblasts and CHO cells. ATP-induced TGF-α shedding required calcium and was independent of Src family kinases and PKC and MAPK signaling. Moreover, ATP-induced TGF-α shedding was completely inhibited by scavengers of ROS, whereas calcium-stimulated shedding was partially inhibited by ROS scavenging. Hydrogen peroxide restored TGF-α shedding after calcium chelation. Importantly, we also found that ATP-induced shedding was independent of the cytoplasmic NADPH oxidase complex. Instead, mitochondrial ROS production increased in response to ATP and mitochondrial oxidative complex activity was required to activate TACE-dependent shedding. These results reveal an essential role for mitochondrial ROS in regulating GPCR-induced growth factor shedding.
title: Differentiation between benign and malignant giant cell tumor of the tendon sheaths – demographic, clinic and radiologic characteristics of a large monocentric cohort.
Creators: name: Kaufmann-Bühler, Ann-Katrin
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Extremities
subject: Musculoskeletal joint
subject: Musculoskeletal soft tissue
subject: MR
subject: Surgery
subject: Pathology
subject: Tissue characterisation

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: To highlight the imaging, histological and clinical features of TGCT subtypes. To provide information on prevalence of tumor recurrence and malignant transformation in a large monocentric...
On the possibility of Galactic Cosmic Ray-induced radiolysis-powered life in subsurface environments in the Universe
Creators: name: Atri, Dimitra
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Populations and Evolution (q-bio.PE)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Photosynthesis is a mechanism developed by terrestrial life to utilize the energy from photons of solar origin for biological use. Subsurface regions are isolated from the photosphere, and consequently are incapable of utilizing this energy. This opens up the opportunity for life to evolve alternate mechanisms for harvesting available energy. Bacterium Candidatus Desulforudis audaxviator, found 2.8 km deep in a South African mine, harvests energy from radiolysis, induced by particles emitted from radioactive U, Th and K present in surrounding rock. Another radiation source in the subsurface environments is secondary particles generated by Galactic Cosmic Rays (GCRs). Using Monte Carlo simulations, it is shown that it is a steady source of energy comparable to that produced by radioactive substances, and the possibility of a slow metabolizing life flourishing on it cannot be ruled out. Two mechanisms are proposed through which GCR-induced secondary particles can be utilized for biological use in subsurface environments: (1) GCRs injecting energy in the environment through particle-induced radiolysis, and (2) organic synthesis from GCR secondaries interacting with the medium. Laboratory experiments to test these hypotheses are also proposed. Implications of these mechanisms on finding life in the Solar System and elsewhere in the Universe are discussed.
description: Accepted for publication in the Journal of the Royal Society Interface
Tailoring superelasticity of soft magnetic materials
Creators: name: Cremer, Peet
name: Löwen, Hartmut
name: Menzel, Andreas M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Embedding magnetic colloidal particles in an elastic polymer matrix leads to smart soft materials that can reversibly be addressed from outside by external magnetic fields. We discover a pronounced nonlinear superelastic stress-strain behavior of such materials using numerical simulations. This behavior results from a combination of two stress-induced mechanisms: a detachment mechanism of embedded particle aggregates as well as a reorientation mechanism of magnetic moments. The superelastic regime can be reversibly tuned or even be switched on and off by external magnetic fields and thus be tailored during operation. Similarities to the superelastic behavior of shape-memory alloys suggest analogous applications, with the additional benefit of reversible switchability and a higher biocompatibility of soft materials.
(401595) George Jack
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Nonexistence of Lyapunov Exponents for Matrix Cocycles
Creators: name: Tian, Xueting
Publisher: name: arXiv
Year: 2015
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics

description: It follows from Oseledec Multiplicative Ergodic Theorem that the Lyapunov-irregular set of points for which the Oseledec averages of a given continuous cocycle diverge has zero measure with respect to any invariant probability measure. In strong contrast, for any dynamical system $f:X\rightarrow X$ with exponential specification property and a H$\ddot{\text{o}}$lder continuous matrix cocycle $A:X\rightarrow G (m,\mathbb{R})$, we show here that if there exist ergodic measures with different Lyapunov spectrum, then the Lyapunov-irregular set of $A$ is residual (i.e., containing a dense $G_δ$ set).
description: arXiv admin note: substantial text overlap with arXiv:0808.0350 by other authors
Myosin Vc Is a Molecular Motor That Functions in Secretory Granule Trafficking
Creators: name: Donaldson, Julie G.
name: Grode, Kyle D.
name: Jacobs, Damon T.
name: Cheney, Richard E.
name: Weigert, Roberto
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Class V myosins are actin-based motor proteins that have critical functions in organelle trafficking. Of the three class V myosins expressed in mammals, relatively little is known about Myo5c except that it is abundant in exocrine tissues. Here we use MCF-7 cells to identify the organelles that Myo5c associates with, image the dynamics of Myo5c in living cells, and test the functions of Myo5c. Endogenous Myo5c localizes to two distinct compartments: small puncta and slender tubules. Myo5c often exhibits a highly polarized distribution toward the leading edge in migrating cells and is clearly distinct from the Myo5a or Myo5b compartments. Imaging with GFP-Myo5c reveals that Myo5c puncta move slowly (∼30 nm/s) and microtubule independently, whereas tubules move rapidly (∼440 nm/s) and microtubule dependently. Myo5c puncta colocalize with secretory granule markers such as chromogranin A and Rab27b, whereas Myo5c tubules are labeled by Rab8a. TIRF imaging indicates that the granules can be triggered to undergo secretion. To test if Myo5c functions in granule trafficking, we used the Myo5c tail as a dominant negative and found that it dramatically perturbs the distribution of granule markers. These results provide the first live-cell imaging of Myo5c and indicate that Myo5c functions in secretory granule trafficking.
In situ preparation and characterization of novel CuI-functionalized poly[(methyl methacrylate)-co-maleimide] as an efficient heterogeneous catalyst in the regioselective synthesis of 1,2,3-triazoles via click reaction: Experimental and computational chemistry
Creators: name: Heravi, Majid Mommahed
name: Nargess Pourmohammad
name: Ahmadi, Shervin
name: Tayebeh Hosseinnejad
Publisher: name: figshare
Year: 2020
Subjects: subject: 30302 Nanochemistry and Supramolecular Chemistry
subject: FOS: Chemical sciences
subject: 30502 Natural Products Chemistry
subject: 30205 Non-metal Chemistry
subject: Nuclear Chemistry
subject: 30303 Optical Properties of Materials
subject: 30503 Organic Chemical Synthesis
subject: Organic Chemistry
subject: 30599 Organic Chemistry not elsewhere classified
subject: 30504 Organic Green Chemistry

description: A CuI‐functionalized poly[(methyl methacrylate)‐co‐maleimide] (CuI@[PMMA‐co‐MI]) nanocatalyst was prepared from in situ polymerization and functionalization of poly[(methyl methacrylate)‐co‐(maleic anhydride)] and well characterized using various techniques. From a computational viewpoint, we assessed two complexation models between copper nanoparticles and [PMMA‐co‐MI]. In this line, the metal–ligand interaction strength was also studied via density functional theory calculations and frontier molecular orbital analysis. Moreover, for presenting a quantitative description of the electronic features of immobilization of copper nanoparticles on polymeric support, the topological analysis of electron density and its Laplacian was performed through quantum theory of atoms in molecules. Finally, the catalytic activity of CuI@[PMMA‐co‐MI] as a heterogeneous nanocatalyst was successfully examined in the highly regioselective synthesis of 1,4‐disubstituted 1,2,3‐triazoles via click reaction.
title: Association of pericardial fat volume quantified by multidetector computed tomography with the severity of coronary artery disease- A study in Indian population
Creators: name: S, Sunil Kumar
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Cardiac
subject: CT-Angiography
subject: CAD
subject: Arteriosclerosis

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Pericardial fat volume quantification by multi-detector computed tomography (MDCT). Estimation of severity of coronary artery disease (CAD) by CT coronary angiogram (CTCA). To establish “Association of pericardial fat volume quantified by...
title: Subcortical U-fibers involvement in white matter disorders: bridging theory and practice
Creators: name: Mavroian, Andrei
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Anatomy
subject: CNS
subject: Neuroradiology brain
subject: MR
subject: Education
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To understand the underlying mechanism involving the subcortical U-fibers in white matter disorders. To extract key diagnostic and practical points in the MRI appearance of white matter...
Supplementary Material for: Kin selection of time travel: the social evolutionary causes and consequences of dormancy
Creators: name: Twyman, Kalyani Z.
name: Gardner, Andy
Publisher: name: The Royal Society
Year: 2023
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Bioinformatics
subject: FOS: Computer and information sciences
subject: Animal Behaviour
subject: Biological Mathematics

description: A basic mechanism of kin selection is limited dispersal, whereby individuals remain close to their place of origin such that even indiscriminate social interaction tends to modify the fitness of genealogical kin. Accordingly, the causes and consequences of dispersal have received an enormous amount of attention in the social evolution literature. This work has focused on dispersal of individuals in space, yet similar logic should apply to dispersal of individuals in time—e.g. dormancy. We investigate how kin selection drives the evolution of dormancy and how dormancy modulates the evolution of altruism. We recover dormancy analogues of key results that have previously been given for dispersal, showing that: (1) kin selection favours dormancy as a means of relaxing competition between relatives; (2) when individuals may adjust their dormancy behaviour to local density, they are favoured to do so, resulting in greater dormancy in high-density neighbourhoods and a concomitant ‘constant non-dormant principle’; (3) when dormancy is constrained to be independent of density, there is no relationship between the rate of dormancy and the evolutionary potential for altruism; and, (4) when dormancy is able to evolve in a density-dependent manner, a greater potential for altruism is expected in populations with lower dormancy.
title: Uncommon prostatic diseases and new PI-RADS v2.1. What radiologist needs to know.
Creators: name: Vicaría Fernández, Iván
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Genital / Reproductive system male
subject: MR
subject: Education
subject: Structured reporting
subject: Cancer
subject: Education and training
subject: Hyperplasia / Hypertrophy

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Learnign objectives: - Get radiologists used to uncommon prostatic diseases.- Review the new PI-RADS v2.1 and MRI protocol proposed.- Make a summary of prostate anatomy and give examples of different common and uncommon conditions that can affect...
(401597) Janet Edward
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.