cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: The walking IUDs: "The gynecologists nightmare"
Creators: name: Maldonado Schoijet, Ignacio
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Foreign bodies
subject: Diagnostic procedure
subject: CT
subject: Pelvis
subject: Genital / Reproductive system female
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The aim of this review is to characterize the imagenologic findings of intrauterine devices misplaced, migration and the possible secondary...
Additional file 1 of Development of the Mental Health Peer Support Questionnaire in colleges and vocational schools in Singapore
Creators: name: Ma, QianHui
name: Gallo, Joseph J.
name: Parisi, Jeanine M.
name: Joo, Jin Hui
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 1. EFA model comparison statistics.
Preparation and Characterization of Tetrabenazine Enantiomers against Vesicular Monoamine Transporter 2
Creators: name: Greig, Nigel H.
name: Katz, Jonathan L.
name: Holloway, Harold W.
name: Kopajtic, Theresa
name: Deschamps, Jeffery
name: Yu, Qian Sheng
name: Luo, Weiming
name: Brossi, Arnold
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: As a clinical medication for the treatment of hyperkinetic movement disorders, in conditions such as Huntington's disease, tetrabenazine (TBZ) has always been used in its racemic form. To establish whether or not its beneficial therapeutic actions are enantiospecific, a practical total synthetic route was developed to yield each enantiomeric form to allow their chemical and pharmacological characterization. We briefly summarize the total synthesis of TBZ and report a detailed procedure for resolution of TBZ into its enantiomers, (+)-TBZ and (−)-TBZ. This allowed determination of the optical rotation and absolute configurations of each TBZ enantiomer, based on X-ray crystallographic analysis, together with characterization of their inhibitory action at the vesicular monoamine transporter 2, where (+)-TBZ proved 3-fold more active than (−)-TBZ.
title: From eye to brain : Imaging of orbital apex
Creators: name: Choi, Samantha
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Eyes
subject: Head and neck
subject: Ear / Nose / Throat
subject: CT
subject: MR
subject: Education
subject: Technical aspects
subject: Cancer
subject: Infection
subject: Lymphoma

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The purpose of this exhibit is to: Demonstrate, with cross sectional imaging and schematic diagrams, the normal anatomy of the orbital apex Describe the clinical manifestations of orbital apex syndrome Provide a protocol for imaging of patients with...
THE POLITICS OF CHILDCARE IN SOUTHERN EUROPE: DIFFERENT TRENDS AND OUTCOMES IN ITALIAN AND SPANISH REGIONS
Creators: name: SORRENTI, ANTONINO
Publisher: name: Universit� degli Studi di Milano
Year: 2020

description: Italy and Spain have been traditionally characterized by underdeveloped childcare and persistent familism in the provision of care (Ferrera 1996, 2005a). However, in the last two decades, childcare has undergone an expansionary as well as divergent trajectory in Italy and Spain. An high childcare expansion coincided with the increase of public delivery and level of inclusiveness in Spain. By contrast, childcare expansion in Italy was moderate, driven by private sector and less inclusive than in Spain. Therefore, childcare policy change in both countries has varied along three analytical dimensions: the extent of expansion, the way childcare is delivered and the level of inclusiveness. The latter ? if combined with the delivery of high quality service - is particularly relevant to achieve effective social investment aims on childcare reforms (Bonoli 2017; West et. al. 2019). In both countries regional governments hold key competences on the three dimensions of change (expansion, delivery and social investment). Due to a decentralized policy setting, Italian and Spanish regions distribute financial resources to the lower level of childcare implementation. Against this backdrop, we develop an empirical analysis of regional childcare trajectory in order to understand the determinants of Italian and Spanish divergence on childcare expansion, delivery and social investment. Trough an in-depth reconstruction of policy-making processes in four regional cases ? Andalusia, Rioja, Tuscany and Piedmont - we show that government colours and political competition dynamics still matter for childcare expansion. Also, political competition dynamics ? rather than government colour ? turn to be relevant to explain the shift from a social assistance to a social investment approach on childcare. Finally, political exchange dynamics between service providers, interested to expand their childcare supply, and governments looking for political support and sharing responsibilities on childcare policy, are crucial to explain changes on childcare delivery.
MRSAD-PHASING OF LARGE MACROMOLECULAR COMPLEXES
Creators: name: PEDERZOLI, RICCARDO
Publisher: name: Universit� degli Studi di Milano
Year: 2020

description: L?obiettivo del presente lavoro di Tesi � lo studio sistematico del metodo MRSAD, un metodo di fasamento cristallografico che sta diventando sempre pi� un importante strumento nelle mani dei cristallografi, in particolare per quanto riguarda la risoluzione del crescente numero di strutture biologiche a elevato peso molecolare. Il metodo MRSAD � stato testato su diverse proteine a basso e medio peso molecolare e nel caso del proteasoma 20S umano, sfruttando la presenza di modelli depositati nel Protein Data Bank (PDB) che hanno reso possibile la comparazione e la valutazione dei risultati. L?applicabilit� di una procedura generale per il fasamento e la costruzione di un modello nelle fasi MRSAD � stata studiata, cos� come l?effetto di procedure di ?density modification?, la completezza dei modelli per Molecular Replacement, la loro accuratezza e la multiplicit� dei dati cristallografici. I risultati ottenuti dall?analisi di dati relativi ad un?ampia variet� di sistemi modello permettono di ricavare conclusioni sulle potenzialit� e sui limiti del fasamento attraverso MRSAD, e suggeriscono alcune linee guida per la sua applicazione al fine di massimizzare il suo successo. In aggiunta, il fasamento attraverso MRSAD � stato testato positivamente in due casi reali: il primo � rappresentato dall?uso di MRSAD per la risoluzione della struttura del primo recettore del glutammato di pianta. Il secondo riguarda invece l?impiego di MRSAD per il fasamento di antigeni attraverso l?impiego di nano-anticorpi (?nanobodies?) ingegnerizzati con una sequenza in grado di legare ioni di lantanidi, sviluppati recentemente all?interno del gruppo. Il lavoro di Tesi ha anche riguardato la determinazione di alcune strutture rimaste a lungo irrisolte. In questi casi, non � stato possibile ricorrere all?uso di MRSAD a causa della mancanza di dati con segnale anomalo, ed altre strategie di fasamento sono state impiegate. Ognuna delle strutture che � stata risolta rappresenta un caso difficile con le sue proprie peculiarit�, ed un ampio spettro di strategie di fasamento e metodi di miglioramento delle fasi � stato impiegato per la loro risoluzione.
(101219) Charles John Simmons
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Rational Drug Design Leading to the Identification of a Potent 5-HT 2C Agonist Lacking 5-HT 2B Activity
Creators: name: Sassano, Maria F.
name: Svennebring, Andreas
name: Kozikowski, Alan P.
name: Jensen, Niels H.
name: Roth, Bryan L.
name: Cho, Sung Jin
name: Huang, Xi Ping
name: Chen, Gang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The 5-HT2C receptor is an attractive drug target in the quest for new therapeutics to treat a variety of human disorders. We have previously undertaken a structural optimization campaign that has led to some potent and moderately selective 5-HT2C receptor agonists. After expanding our structure–function library, we were able to combine our data sets so as to allow the design of compounds of improved selectivity and potency. We disclose herein the structural optimization of our previously reported 5-HT2B/5-HT2C agonists, which has led to the identification of a highly selective 5-HT2C agonist, (+)-trans-[2-(2-cyclopropylmethoxyphenyl)cyclopropyl]methylamine hydrochloride, with an EC50 of 55 nM and no detectable agonism at the 5-HT2B receptor.
MPEC 2024-R183 : 2024 RG7
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 RG7

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
CONTRIBUTION OF BASAL GANGLIA, CEREBELLUM AND PARIETAL OPERCULUM TO ANTICIPATORY POSTURAL ADJUSTMENTS
Creators: name: MARCHESE, SILVIA MARIA
Publisher: name: Universit� degli Studi di Milano
Year: 2020

description: Anticipatory Postural Adjustments (APAs) are a crucial aspect of the voluntary movement organization, being fundamental in stabilizing both the whole-body (inter-limb APAs) and its segments (intra-limb APAs). Until now, only a few works investigated the neural structures involved in APAs programming, by correlating neurological diseases with APAs changes. This approach clarified not only the knowledge regarding these pathologies, but also the relationships between these structures and the APA command. So, to enrich the comprehension about the neural network generating and influencing APAs, this thesis is focused on two aspects. The first part investigated the role of two subcortical structures, basal ganglia and cerebellum, in APAs organization. In particular, it was analyzed (i) how intra-limb APAs stabilize the arm and the forearm, when flexing the index-finger, in patients with basal ganglia dysfunction, as well as (ii) the inter-limb APAs associated to gait initiation in children with cerebellar ataxia. Results showed that basal ganglia seem to be involved in APA control, since the normal pattern of intra-limb APAs is disrupted in parkinsonian patients. On the other hand, the role of the cerebellum as a timing-machine was confirmed, since several alterations were found in the temporal organization of inter-limb APAs in ataxic vs. healthy children. Considering recent studies showing that basal ganglia and cerebellum are reciprocally interconnected and that the cerebellum exerts a functional compensatory activity in parkinsonian patients, it could be interesting to address future studies to inquire a reciprocal compensatory role of basal ganglia in cerebellar disease. The second part dealt with the possible influence of cognitive processes on APA control. To achieve this goal, a cerebellar area with a well-known cognitive role, Crus I-II, was examined. In this context, a protocol of Magnetic Resonance Spectroscopy was developed, able to characterize and quantify metabolites in a cerebellar area of interest. The protocol was validated in healthy subjects and could be used in future investigations of neurological diseases affecting postural and motor control. Finally, the Parietal Operculum (PO) activity was studied. This is a cortical sensory-motor integration center, notably involved in a multimodal network. So, intra-limb APAs associated to index-finger flexion were analyzed in healthy subjects before, during and after modulating the contralateral PO (coPO) excitability by anodal and cathodal transcranial Direct Current Stimulation (tDCS). Since no significant effects were found on intra-limb APAs amplitude and timing, the coPO does not seem to be involved in APA control. However, future studies should address the possible influence of both POs by bilateral tDCS.
The Fractality of Polar and Reed-Muller Codes
Creators: name: Geiger, Bernhard C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: The generator matrices of polar codes and Reed-Muller codes are obtained by selecting rows from the Kronecker product of a lower-triangular binary square matrix. For polar codes, the selection is based on the Bhattacharyya parameter of the row, which is closely related to the error probability of the corresponding input bit under sequential decoding. For Reed-Muller codes, the selection is based on the Hamming weight of the row. This work investigates the properties of the index sets pointing to those rows in the infinite blocklength limit. In particular, the Lebesgue measure, the Hausdorff dimension, and the self-similarity of these sets will be discussed. It is shown that these index sets have several properties that are common to fractals.
description: 9 pages, one figure
MPEC 2024-R184 : 2024 RH7
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 RH7

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
title: Measuring Radiology Report Quality Using Multimedia Structured Reporting
Creators: name: Vining, David
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Workforce
subject: Quality assurance
subject: Outcomes
subject: Structured reporting
subject: Health policy and practice
subject: Computer Applications-General
subject: Teleradiology
subject: RIS
subject: PACS
subject: Professional issues
subject: Management
subject: Computer applications

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Demonstrate how a multimedia structured reporting technique can be used to measure the quality of Information contained within radiology...
Detection of Extremely Broad Water Emission from the molecular cloud interacting Supernova Remnant G349.7+0.2
Creators: name: Rho, J.
name: Hewitt, J. W.
name: Boogert, A.
name: Kaufman, M.
name: Gusdorf, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We performed Herschel HIFI, PACS and SPIRE observations towards the molecular cloud interacting supernova remnant G349.7+0.2. An extremely broad emission line was detected at 557 GHz from the ground state transition 1_{10}-1_{01} of ortho-water. This water line can be separated into three velocity components with widths of 144, 27 and 4 km/s. The 144 km/s component is the broadest water line detected to date in the literature. This extremely broad line width shows importance of probing shock dynamics. PACS observations revealed 3 additional ortho-water lines, as well as numerous high-J carbon monoxide (CO) lines. No para-water lines were detected. The extremely broad water line is indicative of a high velocity shock, which is supported by the observed CO rotational diagram that was reproduced with a J-shock model with a density of 10^4 cm^{-3} and a shock velocity of 80 km/s. Two far-infrared fine-structure lines, [O~I] at 145 micron and [C~II] line at 157 micron, are also consistent with the high velocity J-shock model. The extremely broad water line could be simply from short-lived molecules that have not been destroyed in high velocity J-shocks; however, it may be from more complicated geometry such as high-velocity water bullets or a shell expanding in high velocity. We estimate the CO and H2O densities, column densities, and temperatures by comparison with RADEX and detailed shock models. Detection of Extremely Broad Water Emission from the molecular cloud interacting Supernova Remnant G349.7+0.2
Design, Synthesis, and Testing of a Molecular Truck for Colonic Delivery of 5-Aminosalicylic Acid
Creators: name: Alleti, Ramesh
name: Ahad, Ali M.
name: Midura-Kiela, Monica T.
name: Woodford, Rita Marie T.
name: Navath, Suryakiran
name: Rao, Venkataramanarao
name: Kiela, Pawel R.
name: Mash, Eugene A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: A molecular scaffold bearing eight terminal alkyne groups was synthesized from sucrose. Eight copies of an azide-terminated, azo-linked precursor to 5-aminosalicylic acid were attached to the scaffold via copper(I)-catalyzed azide–alkyne cycloaddition. The resulting compound was evaluated in a DSS model of colitis in BALB/c mice against sulfasalazine as a control. Two independent studies verified that the novel pro-drug, administered in a dose calculated to result in an equimolar 5-ASA yield, outperformed sulfasalazine in terms of protection from mucosal inflammation and T cell activation. A separate study established that 5-ASA appeared in feces produced 24–48 h following administration of the pro-drug. Thus, a new, orally administered pro-drug form of 5-aminosalicylic acid has been developed and successfully demonstrated.
MICROENVIRONMENT FACTORS PROMOTING THE QUALITY OF IMMATURE VITRIFIED OOCYTES IN THE DOMESTIC CAT MODEL
Creators: name: COLOMBO, MARTINA
Publisher: name: Universit� degli Studi di Milano
Year: 2021

description: Gli oociti immaturi vitrificati (VOs) di gatto domestico sono un modello utile per sviluppare protocolli di crioconservazione dei gameti per la salvaguardia della fertilit� e della biodiversit� nei felini selvatici a rischio estinzione. Sebbene la vitrificazione di oociti immaturi sia conveniente per i suoi vantaggi pratici (disponibilit� di gameti, velocit� e possibilit� di esecuzione in campo della tecnica), i VOs spesso degenerano dopo il warming (i.e. il ripristino della temperatura fisiologica dopo vitrificazione), e i loro tassi di maturazione e sviluppo embrionale in vitro sono scarsi se comparati a quelli degli oociti freschi. Pertanto, sono necessari miglioramenti per sfruttare appieno il loro potenziale, come degli arricchimenti fisico-chimici al protocollo di vitrificazione o alle condizioni di coltura post-warming. In questo progetto, la vitrificazione di oociti immaturi con il metodo Cryotop ha prodotto tassi di vitalit� elevati (90,8%), ripetibili e riproducibili. Per migliorare la maturazione dei VOs e il loro sviluppo, sono state poi impiegate due strategie. La prima ha previsto la creazione di strutture tridimensionali simil-follicolari (i.e. cellule della granulosa coltivate in microcapsule di alginato), utilizzate come condizione di coltura arricchita per la maturazione in vitro dei VOs, e ha portato al mantenimento dell'attivit� steroidogenica delle cellule della granulosa e alla ripresa della meiosi dei VOs co-coltivati (11,8% di maturazione). La seconda strategia invece, dopo la valutazione dell'attivazione apoptotica nei VOs, ha previsto l'aggiunta di un inibitore chimico delle caspasi che ha prodotto tassi di maturazione (53,1%) simili a quelli degli oociti freschi di controllo e buoni tassi di sviluppo embrionale (34,4%). Lo sviluppo embrionale a stadi avanzati � rimasto scarso, e sono necessarie ulteriori ricerche per ottimizzare la competenza di sviluppo dei VOs. Indagini molecolari sui danni indotti dalla crioconservazione e sulle peculiarit� degli embrioni derivati da oociti crioconservati potrebbero migliorare i risultati dei VOs in vitro, e quindi favorire la creazione di biobanche per i gameti felini.
title: GIST: Radiological approach with pathologic correlation
Creators: name: Riveros Gilardi, Berta
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Cancer
subject: Barium meal
subject: CT
subject: Gastrointestinal tract

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The purpose of this exhibition is to present a check list of basic features to analyse in a gastrointestinal tumor, the CT imaging features that can guide the radiologist towards the diagnosis of Gastrointestinal stromal tumors (GISTs), and a...
L'AUTONOMIA PRIVATA NEI IURA PRAEDIORUM
Creators: name: TURETTA, ALESSIA
Publisher: name: Universit� degli Studi di Milano
Year: 2021

description: La presente ricerca, articolata in tre capitoli, � volta ad analizzare il ruolo che l?autonomia privata ricopr� nell?ambito dei iura praediorum, sia sotto il profilo contenutistico, che sotto quello dinamico dell?usus servitutis. Il primo capitolo esamina il contributo dell?autonomia privata nell?emersione dei primi iura praediorum rusticorum, individuabili in via, iter, actus e aquae ductus, i quali si atteggiavano originariamente a potere dominicale che il titolare del fondo avvantaggiato esercitava su una determinata porzione del fondo vicino. L?origine separata delle prime servit� rustiche ne determin� un?iniziale tipicit�. Le singole facolt� proprie della via ne furono estrapolate nella prassi, per divenire figure autonome. Il successivo intervento giurisprudenziale fu fondamentale per fornire ad iter ed actus un?idonea veste giuridica, mediante la formulazione della nozione di ius in re aliena. Il secondo capitolo � dedicato allo studio del ruolo svolto dai privati nell?emersione della categoria della servitus. Con la genesi dei iura praediorum urbanorum e l?introduzione di nuove servit� rustiche inizia a profilarsi una categoria unitaria con propri caratteri peculiari. Anche in questo contesto si riscontra il ruolo preminente della prassi negoziale, affiancata dall?elaborazione concettuale della giurisprudenza, particolarmente vivace in epoca tardo-repubblicana. Al tema dell?usus servitutis � dedicato il terzo capitolo. Per quanto attiene alle servit� pi� antiche, l?utilizzo prolungato del passaggio o della conduttura d?acqua consentiva il consolidamento di una situazione di fatto in una realt� riconosciuta dal diritto. Tale usus della servit� fu oggetto anche di una specifica tutela interdittale. Quanto al modus, si esclude che potesse avere una funzione correttiva della tipicit� dei iura praediorum: esso, attienente unicamente all?esercizio del diritto, non incideva sul contenuto delle singole servit� e non ne modificava l?utilitas. Si ritiene, in conclusione, che i privati restassero liberi di riversare nel modello delineato dalla giurisprudenza le utilit� che le nuove esigenze socio-economiche richiedevano, nel rispetto dei caratteri delineati dalla giurisprudenza. Si pu�, pertanto, notare una distinzione tra servit� nominate, ampiamente analizzate dalla giurisprudenza, e servit� innominate, emerse dalla vivacit� della prassi negoziale.
(101220) Edward Hardwick
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Discovery of Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia
Creators: name: Yang, Chao
name: Janzen, William P.
name: Deryckere, Deborah
name: Norris-Drouin, Jacqueline
name: Graham, Douglas K.
name: Van Deusen, Amy
name: Patel, Hari S.
name: Miley, Michael J.
name: MacHius, Mischa
name: Hunter, Debra
name: Liu, Jing
name: Kireev, Dmitri
name: Earp, H. Shelton
name: Wang, Xiaodong
name: Simpson, Catherine
name: Korboukh, Victoria K.
name: Frye, Stephen V.
name: Johnson, Gary L.
name: Sather, Susan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Ectopic Mer expression promotes pro-survival signaling and contributes to leukemogenesis and chemoresistance in childhood acute lymphoblastic leukemia (ALL). Consequently, Mer kinase inhibitors may promote leukemic cell death and further act as chemosensitizers increasing efficacy and reducing toxicities of current ALL regimens. We have applied a structure-based design approach to discover novel small molecule Mer kinase inhibitors. Several pyrazolopyrimidine derivatives effectively inhibit Mer kinase activity at sub-nanomolar concentrations. Furthermore, the lead compound shows a promising selectivity profile against a panel of 72 kinases and has excellent pharmacokinetic properties. We also describe the crystal structure of the complex between the lead compound and Mer, opening new opportunities for further optimization and new template design.
(101221) Henry Horse
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Urinary tract malformations. Do not miss it! - Prenatal diagnosis
Creators: name: Vieira, Ana
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Foetus
subject: Diagnostic procedure
subject: Ultrasound
subject: MR
subject: Kidney
subject: Urinary Tract / Bladder
subject: Foetal imaging
subject: Obstetrics

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Recognize the importance of prenatal ultrasound imaging in the diagnosis of urinary tract malformations Describe the different types of urinary tract diseases and prenatal manifestations Illustrate the imaging features of urinary tract malformation...
Additional file 1 of A long-term cost-effectiveness analysis of cardiac resynchronisation therapy with or without defibrillator based on health claims data
Creators: name: Hadwiger, Moritz
name: Schumann, Laura
name: Eisemann, Nora
name: Dagres, Nikolaos
name: Hindricks, Gerhard
name: Haug, Janina
name: Wolf, Michael
name: Marschall, Ursula
name: Katalinic, Alexander
name: Frielitz, Fabian-Simon
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1. A long-term cost-effectiveness analysis of cardiac resynchronisation therapy with or without defibrillator based on health claims data.
MPEC 2024-R185 : 2024 RJ7
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 RJ7

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
title: Expected Changes at Doppler Ultrasound in orthotopic liver transplantation
Creators: name: FLORES, NATALI
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Liver
subject: Abdomen
subject: Ultrasound-Colour Doppler
subject: Ultrasound-Spectral Doppler
subject: Ultrasound
subject: eLearning
subject: Education
subject: Transplantation

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To review imaging evaluation in immediate post-operative liver transplantation. To identify transitory changes at Doppler US in orthotopic liver transplantation. Show our experience of the transitory changes on US Doppler in patients at Carlos...
(101218) Elizabeth Jenkins
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Evolution of jaws CBCT findings in bisphosphonate related osteonecrosis
Creators: name: Cosentino, Aurelio
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Cone beam CT
subject: Head and neck
subject: Staging
subject: Demineralisation-Bone

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Usefulness of Cone beam computed tomography is well recognized when investigating the features of bisphosphonate-related osteonecrosis of the jaw (BRONJ) (1,2) whose incidence is about 1% in patients with cancer exposed to zoledronate (3)....
Synthesis of Lithocholic Acid Derivatives as Proteasome Regulators
Creators: name: Chen, Chin Ho
name: Qian, Keduo
name: Lee, Kuo Hsiung
name: Dang, Zhao
name: Huang, Li
name: Jung, Kathy
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Accumulation of aberrant protein aggregates, such as amyloid β peptide (Aβ), due to decreased proteasome activities, might contribute to the neurodegeneration in Alzheimer's disease. In this study, lithocholic acid derivatives 3α-O-pimeloyl-lithocholic acid methyl ester (2) and its isosteric isomer (6) were found to activate the chymotrypsin-like activity of the proteasome at an EC50 of 7.8 and 4.3 μM, respectively. Replacing the C24 methyl ester in 2 with methylamide resulted in a complete devoid of proteasome activating activity. Epimerizing the C3 substituent from an α to β orientation transformed the activator into a proteasome inhibitor. Unlike the cellular proteasome activator PA28, proteasome activated by 2 was not inhibited by Aβ. Furthermore, 2 potently antagonized the inhibitory effect of Aβ on the proteasome. In summary, compound 2 represents a novel class of small molecules that not only activates the proteasome but also antagonizes the inhibitory effect of Aβ on the proteasome.
Additional file 1 of Characterization of ACE2 naturally occurring missense variants: impact on subcellular localization and trafficking
Creators: name: Badawi, Sally
name: Mohamed, Feda E.
name: Alkhofash, Nesreen R.
name: John, Anne
name: Ali, Amanat
name: Ali, Bassam R.
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology

description: Additional file 1. list of ACE2 mutagenesis primers and benign ACE2 variants by prediction tools.
title: The failling wall - Prenatal diagnosis of anterior abdominal wall defects
Creators: name: Vieira, Ana
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Foetus
subject: Diagnostic procedure
subject: Ultrasound
subject: MR
subject: Gastrointestinal tract
subject: Abdomen
subject: Foetal imaging
subject: Hernia

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To recognize the importance of prenatal ultrasound imaging in the diagnose of abdominal wall defects To describe the different types of anterior abdominal wall defects with embryology correlation To illustrate the imaging features of the anterior...
Etude mathematique de mod�les non lin�aires issus de la physique quantique relativiste.
Creators: name: ROTA NODARI, SIMONA
Publisher: name: Universit� degli Studi di Milano
Year: 2011

description: "This thesis is devoted to the study of two nonlinear relativistic quantum models. In the first part, we prove by a perturbation method the existence of solutions of the coupled Einstein?Dirac?Maxwell equations for a static, spherically symmetric system of two fermions in a singlet spinor state and for a weak electromagnetic coupling. In the second part, we study a relativistic mean-field model that describes the behavior of nucleons in the atomic nucleus. We provide a condition that ensures the existence of a ground state solution of the relativistic mean-field equations in a static case; in particular, we relate the existence of critical points of a strongly indefinite energy functional to strict concentration-compactness inequalities.
(101215) Alfred Arnold Davies
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Discovery of Inhibitors of Burkholderia pseudomallei Methionine Aminopeptidase with Antibacterial Activity
Creators: name: Henderson, Michael W.
name: Horn, James R.
name: Wangtrakuldee, Phumvadee
name: Myler, Peter J.
name: Masoudi, Ali
name: Zhang, Zheng
name: Hagen, Timothy J.
name: Clare, Michael
name: Byrd, Matthew S.
name: Campos, Cristine G.
name: Cotter, Peggy A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Evaluation of a series of MetAP inhibitors in an in vitro enzyme activity assay led to the first identification of potent molecules that show significant growth inhibition against Burkholderia pseudomallei. Nitroxoline analogues show excellent inhibition potency in the BpMetAP1 enzyme activity assay with the lowest IC50 of 30 nM and inhibit the growth of B. pseudomallei and B. thailandensis at concentrations ≥31 μM.
(101216) Ralph Lambton Hopper
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Pseudoneoplastic paratesticular lesions
Creators: name: Sierra Vinuesa, Ana
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Neoplasia
subject: Cysts
subject: Acute
subject: Diagnostic procedure
subject: Ultrasound-Colour Doppler
subject: Ultrasound
subject: MR
subject: Genital / Reproductive system male
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Enumerate pseudoneoplastic paratesticular entities arising on the basis of their characteristic radiology, clinical and differential diagnostic features. Describe the morphologic features of paratesticular benign mimickers and pseudotumors and how...
Additional file 2 of Characterization of ACE2 naturally occurring missense variants: impact on subcellular localization and trafficking
Creators: name: Badawi, Sally
name: Mohamed, Feda E.
name: Alkhofash, Nesreen R.
name: John, Anne
name: Ali, Amanat
name: Ali, Bassam R.
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: 60506 Virology

description: Additional file 2. Supplementary figures.
Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor
Creators: name: Besnard, Jérémy
name: Wingler, Laura M.
name: Ahn, Seungkirl
name: Navratilova, Iva
name: Zhu, Xiao
name: Read, Kevin D.
name: Riley, Jennifer
name: Gilbert, Ian H.
name: Roth, Bryan L.
name: Sassano, Maria F.
name: Shukla, Arun K.
name: Huang, Xi Ping
name: Aristotelous, Tonia
name: Kahsai, Alem W.
name: Lefkowitz, Robert J.
name: Gawron, Sylwia
name: Tripathi-Shukla, Prachi
name: Hopkins, Andrew L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: G-protein coupled receptors (GPCRs) are the primary target class of currently marketed drugs, accounting for about a quarter of all drug targets of approved medicines. However, almost all the screening efforts for novel ligand discovery rely exclusively on cellular systems overexpressing the receptors. An alternative ligand discovery strategy is a fragment-based drug discovery, where low molecular weight compounds, known as fragments, are screened as initial starting points for optimization. However, the screening of fragment libraries usually employs biophysical screening methods, and as such, it has not been routinely applied to membrane proteins. We present here a surface plasmon resonance biosensor approach that enables, cell-free, label-free, fragment screening that directly measures fragment interactions with wild-type GPCRs. We exemplify the method by the discovery of novel, selective, high affinity antagonists of human β2 adrenoceptor.
Identification and Synthesis of Quinolizidines with Anti-Influenza A Virus Activity
Creators: name: Zhu, Lei
name: Lai, Weihong
name: Dang, Zhao
name: Xie, Hua
name: Jung, Katherine
name: Lee, Kuo Hsiung
name: Chen, Chin Ho
name: Huang, Li
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Influenza A virus infection causes a contagious respiratory illness that poses a threat to human health. However, there are limited anti-influenza A therapeutics available, which is further compounded by the emergence of drug resistant viruses. In this study, Sophora quinolizidine alkaloids were identified as a new class of anti-influenza A virus agents. Among the tested Sophora alkaloids, dihydroaloperine exhibited the most potent activity with an EC50 of 11.2 μM. The potency of the quinolizidine alkaloids was improved by approximately 5-fold with chemical modifications on the aloperine molecule. These compounds were effective against an H1N1 influenza A virus that was resistant to the two antiflu drugs oseltamivir and amantadine. The identification of the quinolizidine alkaloids as effective and novel anti-influenza A agents may aid in the development of new therapeutics.
Nonassociative geometry in quasi-Hopf representation categories II: Connections and curvature
Creators: name: Barnes, Gwendolyn E.
name: Schenkel, Alexander
name: Szabo, Richard J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Algebra (math.QA)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: Category Theory (math.CT)
subject: FOS: Mathematics
subject: FOS: Physical sciences
subject: 16T05, 17B37, 46L87, 53D55

description: We continue our systematic development of noncommutative and nonassociative differential geometry internal to the representation category of a quasitriangular quasi-Hopf algebra. We describe derivations, differential operators, differential calculi and connections using universal categorical constructions to capture algebraic properties such as Leibniz rules. Our main result is the construction of morphisms which provide prescriptions for lifting connections to tensor products and to internal homomorphisms. We describe the curvatures of connections within our formalism, and also the formulation of Einstein-Cartan geometry as a putative framework for a nonassociative theory of gravity.
description: 29 pages. v2: Final version published in Journal of Geometry and Physics
Bactericidal Efficacy of Nitric Oxide-Releasing Silica Nanoparticles
Creators: name: Stasko, Nathan A.
name: Johnson, C. Bryce
name: Schoenfisch, Mark H.
name: Holmuhamedov, Ekhson
name: Shin, Jae Ho
name: Hetrick, Evan M.
name: Wespe, Daniel A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The utility of nitric oxide (NO)-releasing silica nanoparticles as a novel antibacterial is demonstrated against Pseudomonas aeruginosa. Nitric oxide-releasing nanoparticles were prepared via co-condensation of tetraalkoxysilane with aminoalkoxysilane modified with diazeniumdiolate NO donors, allowing for the storage of large NO payloads. Comparison of the bactericidal efficacy of the NO-releasing nanoparticles to 1-[2-(carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (PROLI/NO), a small molecule NO donor, demonstrated enhanced bactericidal efficacy of nanoparticle-derived NO and reduced cytotoxicity to healthy cells (mammalian fibroblasts). Confocal microscopy revealed that fluorescently-labeled NO-releasing nanoparticles associated with the bacteria, providing rationale for the enhanced bactericidal efficacy of the nanoparticles. Intracellular NO concentrations were measurable when the NO was delivered from nanoparticles as opposed to PROLI/NO. Collectively, these results demonstrate the advantage of delivering NO via nanoparticles for antimicrobial applications.
(101217) Susan Plomley Jenkins
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Conservación multidimensional y territorial de los Recursos Genéticos
Creators: name: Defacio, Raquel
Publisher: name: ITPGRFA
Year: 2018
Subjects: ARG
Genomics
PR-154
Traditional knowledge
Local communities
ITPGRFA-BSF
Family farming
Farmers
Conservation
Adaptation
Climate change
Erosion
Resilience
Rescue
Restoration
Production

description: This paper was developed in the framework of the project “Conservación y uso sostenible de los recursos fitogenéticos locales para la alimentación y la agricultura (RFAA) para contribuir a la seguridad alimentaria de los pequeños agricultores de Argentina” funded in the 4th project cycle of Benefit Sharing Fund (BSF) of the International Treaty on Plant Genetic Resources for Food and Agriculture (ITPGRFA) of the Food and Agriculture Organization (FAO).

The aim of this project is to identify, value, rescue and reinsert in the socio-cultural and productive ecosystems of Argentina, the genetic resources of populations at risk of extinction and erosion. In addition, partners from INTA aimed at identifying the concomitant causes of the risks, its processes and mechanisms, through a systemic, multidimensional and territorial approach. The project encourages the recognition and importance of inclusion of local communities in the conservation and preservation of local diversity. They are working through an interdisciplinary approach and territorial working groups. These groups will work with INTA and other institutions, including with the local communities, favoring the  conservation of germplasm and the knowledge associated with it. These actions will make it possible to have germplasm that is adapted to the specific climatic and production conditions  adding cultural, economic and ecological value to the raw material obtained and encourage young people, to revalue the traditional knowledge and the permanence in the sector.