cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Pteris speluncae Christenh. 2011, comb. nov.
Creators: name: Christenhusz, Maarten J. M.
name: Zhang, Xian-Chun
name: Schneider, Harald
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Polypodiales
Pteridaceae
Pteris
Pteris speluncae

description: Pteris speluncae (R.Br.) Christenh., comb. nov.
Basionym: Gleichenia speluncae Brown (1810: 161).
description: Published as part of Christenhusz, Maarten J. M., Zhang, Xian-Chun & Schneider, Harald, 2011, A linear sequence of extant families and genera of lycophytes and ferns, pp. 7-54 in Phytotaxa 19 on page 22, DOI: 10.11646/phytotaxa.19.1.2, http://zenodo.org/record/4893995
Huperzia Bernh., J. Bot. (Schrader 1800
Creators: name: Christenhusz, Maarten J. M.
name: Zhang, Xian-Chun
name: Schneider, Harald
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Lycopodiopsida
Lycopodiales
Lycopodiaceae
Huperzia

description: 1.1. Huperzia Bernh., J. Bot. (Schrader) 1800 (2): 126 (1801).
T.: Huperzia selago (L.) Bernh. ex Schrank & Mart. (Lycopodium selago L.)
description: Published as part of Christenhusz, Maarten J. M., Zhang, Xian-Chun & Schneider, Harald, 2011, A linear sequence of extant families and genera of lycophytes and ferns, pp. 7-54 in Phytotaxa 19 on page 41, DOI: 10.11646/phytotaxa.19.1.2, http://zenodo.org/record/4893995
Gonatocerus Nees ab Esenbeck
Creators: name: Triapitsyn, Serguei V.
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Mymaridae
Gonatocerus

description: Gonatocerus (Lymaenon) sp. 1
(Figs 204, 205)
 Extralimital records. USA. CALIFORNIA, Riverside Co., Riverside, University of California at Riverside (UCR), Department of Entomology Insectary & Quarantine facility, I.M. Bayoun: 20.vii.1998 (third generation on eggs of Neoaliturus tenellus (Baker) on sugar beet) [3 Ƥ, UCRC]; ix.2000 (from culture on eggs of N. tenellus on sugar beet) [4 Ƥ, UCRC], originally from: IRAN. FARS, Kavar, 14–15.v.1998, N. Zareh (from eggs of N. tenellus on sugar beet, Beta vulgaris, leaves, UCR Quarantine S&R # 98-09-02 C).
 Brief diagnosis. FEMALE. Body length 860–920 µm. Head and mesosoma mostly dark brown, gaster light brown to brown; appendages light to dark brown. Antenna (Fig. 204) with mps on F5 (1), F7 (2), F8 (2), and clava (10). Fore wing (Fig. 205) 2.9–3.0× as long as wide, with discal setae originating behind base of marginal vein. Ovipositor 1.2–1.3× length of mesotibia, not exserted beyond apex of gaster. Thus mostly identical to G. litoralis except fore wing disc with a distinct bare area between the marginal vein and the cubital row of setae (Fig. 205).
MALE. Unknown.
 Distribution. PALAEARCTIC: Iran (originally).
 Host. Neoaliturus (Circulifer) tenellus (Baker) (Cicadellidae).
 Comments. This apparently new species is not described as such because only a few laboratory reared specimens are available for study. The original material from Iran was not preserved because it was used for establishing the colony in quarantine and could not be recovered.
description: Published as part of Triapitsyn, Serguei V., 2013, Review of Gonatocerus (Hymenoptera: Mymaridae) in the Palaearctic region, with notes on extralimital distributions, pp. 1-178 in Zootaxa 3644 (1) on page 117, DOI: 10.11646/zootaxa.3644.1.1, http://zenodo.org/record/246888
Lycopodiella Holub
Creators: name: Christenhusz, Maarten J. M.
name: Zhang, Xian-Chun
name: Schneider, Harald
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Lycopodiopsida
Lycopodiales
Lycopodiaceae
Lycopodiella

description: 1.2. Lycopodiella Holub, Preslia 36: 20 (1964).
T.: Lycopodiella inundata (L.) Holub (Lycopodium inundatum L.)
description: Published as part of Christenhusz, Maarten J. M., Zhang, Xian-Chun & Schneider, Harald, 2011, A linear sequence of extant families and genera of lycophytes and ferns, pp. 7-54 in Phytotaxa 19 on page 41, DOI: 10.11646/phytotaxa.19.1.2, http://zenodo.org/record/4893995
Ptisana rolandi-principis Christenh. 2011, comb. nov.
Creators: name: Christenhusz, Maarten J. M.
name: Zhang, Xian-Chun
name: Schneider, Harald
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Marattiopsida
Marattiales
Marattiaceae
Ptisana
Ptisana rolandi-Principis

description: Ptisana rolandi-principis (Rosenst.) Christenh., comb. nov.
Basionym: Marattia rolandi-principis Rosenstock (1911: 162).
description: Published as part of Christenhusz, Maarten J. M., Zhang, Xian-Chun & Schneider, Harald, 2011, A linear sequence of extant families and genera of lycophytes and ferns, pp. 7-54 in Phytotaxa 19 on page 22, DOI: 10.11646/phytotaxa.19.1.2, http://zenodo.org/record/4893995
Lycopodium L.
Creators: name: Christenhusz, Maarten J. M.
name: Zhang, Xian-Chun
name: Schneider, Harald
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Lycopodiopsida
Lycopodiales
Lycopodiaceae
Lycopodium

description: 1.3. Lycopodium L., Sp. Pl. 1100 (1753).
T.: Lycopodium clavatum L.
description: Published as part of Christenhusz, Maarten J. M., Zhang, Xian-Chun & Schneider, Harald, 2011, A linear sequence of extant families and genera of lycophytes and ferns, pp. 7-54 in Phytotaxa 19 on page 41, DOI: 10.11646/phytotaxa.19.1.2, http://zenodo.org/record/4893995
ПОВНОВАЖЕННЯ МІНІСТЕРСТВА ЮСТИЦІЇ УКРАЇНИ У СФЕРІ ДЕРЖАВНОЇ РЕЄСТРАЦІЇ: ЮРИДИЧНИЙ АНАЛІЗ
Creators: name: Войтовський, В. С.
Publisher: name: Zenodo
Year: 2023
Subjects: Міністерство юстиції України, державна реєстрація, повноваження, органи юстиції, воєнний стан, юридичний аналіз, правовий інститут

description: У статті розглянуто  та проаналізовано теоретичні засади щодо поняття державної реєстрації, а також узагальнити повноваження Міністерства юстиції України у сфері державної реєстрації.

Ґрунтовне дослідження поняття державна реєстрація необхідне для побудови повної, актуалізованої, категоріальної і понятійної основи дослідження.

Обгрунтовно, що реєстрацію ототожнюють із державно-владною діяльністю щодо встановлення юридично значущих фактів. Це означає, що він (факт) визнається державою як має юридичне значення у різних видах відносин (адміністративно, земельно-, цивільно-правових); у цьому разі реєстрація є «актом компетентного державного органу, який породжує або підтверджує права та обов’язки».

Автором проведено аналіз теоретичних засад щодо визначення поняття «державна реєстрація», відповідно до якого зроблено висновок про те, що серед науковців немає єдиної думки на визначення даного поняття.

Зазначено, що державна реєстрація – це система правових, організаційних, процедурних заходів, що забезпечують однозначність та обґрунтованість записів про права на об’єкт нерухомості.

На основі норм чинного законодавства виокремлено основні повноваження Міністерства юстиції України у сфері державної реєстрації.

Автором звернуто увагу на те, що державна реєстрація може розглядатися одночасно як правозастосовний акт держави, спрямований на визнання та підтвердження виникнення, обмеження (обтяження), переходу або припинення прав на нерухоме майно, як відповідну діяльність установ юстиції і як правовий інститут.

Державна реєстрація – це   акт офіційного визнання законності відповідних дій, які здійснюються, як правило, органами юстиції.
A Missense Mutation in CHD4 Disrupts Cardiac Development
Creators: name: Scialdone, Angelique
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021
Subjects: Heart

description: Nearly half of cardiac malformations, the leading cause of infant mortality in the United States, are of unknown etiology. Mutations in the Chromodomain Helicase DNA-binding protein 4 (CHD4), the core catalytic component of the Nucleosome Remodeling and Deacetylase (NuRD) complex, lead to cardiac malformations, including atrial and ventricular septal defects. A fatal de novo heterozygous missense mutation, CHD4 M202I, was recently identified in an infant boy with left ventricular hypertrophy and ventricular septal defects. CHD4 M202 maps to a highly evolutionarily conserved domain of CHD4 with no known function, suggesting a novel mechanism through which CHD4 functions to regulate cardiac development. A mouse model with the missense mutation CHD4 M195I (aligns with human CHD4 methionine 202) was generated and we found that homozygotes with this missense mutation exhibit ventricular hyperplasia and thickened ventricular walls, ultimately resulting in neonatal demise at birth. Transcriptomic analyses show genes Bmp10 and Hey2, markers of trabecular and compact myocardial layers, respectively, are dysregulated. Through in-situ hybridization using fluorescent probes, we found that mutant hearts show an expansion of Hey2 into the trabecular layer, while Bmp10 is downregulated. Immunohistochemistry experiments using phospho-histone H3 (PHH3) revealed proliferation of cardiomyocytes is significantly increased in mutant hearts during development. Furthermore, conditionally mutated mice with the missense mutation restricted to the cardiomyocytes also show cardiac and proliferation defects. Our results suggest this missense mutation of CHD4 disrupts ventricle formation and enhances cardiomyocyte proliferation, causing fatal cardiac malformations. Characterizing the mutant phenotypes will allow further advancements and understanding of the critical role CHD4 has in the developing heart.
Isoetes L.
Creators: name: Christenhusz, Maarten J. M.
name: Zhang, Xian-Chun
name: Schneider, Harald
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Lycopodiopsida
Isoetales
Isoetaceae
Isoetes

description: 2.1. Isoëtes L., Sp. Pl. 1100 (1753).
T.: Isoëtes lacustris L.
description: Published as part of Christenhusz, Maarten J. M., Zhang, Xian-Chun & Schneider, Harald, 2011, A linear sequence of extant families and genera of lycophytes and ferns, pp. 7-54 in Phytotaxa 19 on page 41, DOI: 10.11646/phytotaxa.19.1.2, http://zenodo.org/record/4893995
Measurement of the Effects of Cortisol-Induced Epigenetic Changes on Cell Morphology Using  an AI-based Image Recognition Pipeline
Creators: name: Welter, Emma
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: Cellular morphology has been largely described using qualitative language and example images rather than quantitative data, limiting its systematic investigation and practical application. Two novel softwares, ilastik and CellProfiler, have emerged and allow high-throughput analysis of images to yield quantitative metrics such as cell area, perimeter, circularity, and branching using artificial intelligence (AI)-based cell recognition. Here, we created a processing sequence (i.e., 
pipeline) using ilastik and CellProfiler to quantify the morphology of IMR-90 fetal lung fibroblasts. The ilastik program was trained through user annotation in identifying the cell, background, and cell boundary in transmission microscope images, and generated binary images 
with these regions clearly labeled. Composite images were generated using ImageJ, a standard image editing program, through the overlay of the binary ilastik-generated images and DAPI nuclear stains. These composite images were then processed by CellProfiler modules to produce morphological measurements including area, perimeter, pseudopodia length, and circularity. This pipeline was practically utilized to compare the stress-based morphological changes induced by 
cortisol, one of the primary stress hormones in humans, treatment of cells at a chronic physiological level (100 nM). Initial results showed that stressed and vehicle-treated control groups did not differ in any morphological category. However, when cellular proliferation was 
halted at the G1/S boundary of the cell cycle by aphidicolin treatment, it was found that stressed cells were larger in area, perimeter, and projection length, and less circular than non-stressed cells. Previous work done in the laboratory has shown that cortisol treatment increases cellular proliferation through DNA methylation changes, making it vital to halt proliferation to reveal morphological differences. This pipeline can be expanded to other cell types, leaving many more morphological changes to be investigated.
Practices in radiation oncology quality assurance rounds: A scoping review protocol
Creators: name: Bayley, Conrad
name: Lee, Laurence
name: Zhang, Jessica
name: Vaska, Marcus
Publisher: name: OSF Registries
Year: 2024
Subjects: subject: Medicine and Health Sciences
subject: chart review
subject: chart round
subject: oncology rounds
subject: quality assurance
subject: radiation oncology

description: In radiation oncology (RO), quality assurance (QA) rounds are conducted regularly. During these rounds, charts are reviewed with the goal of ensuring standards of care are met, strengthening communication on an allied health team, and monitoring for any potential deficits or areas of improvement. Barriers to effective QA rounds can include time and scheduling commitments, lengthy discussion periods, and lack of equal and consistent contributions from all allied health members present.

Recent studies have examined the implementation of specific practices into QA rounds such as random insertion of realistic errors and Group Consensus Peer Review (Talcott et al. 2020; Duggar et al., 2018). This scoping review aims to (1) provide practicing radiation oncologists a general landscape of current published practices in QA rounds, and (2) inform an improvement study targeting gastrointestinal-focused (GI) RO at the University of Calgary.
The Impact of COVID-19 on Food Expenditures
Creators: name: Barefoot, Acelynn
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Situational shifts, income loss, fear of infection, and restaurant closures all had the potential to impact food purchases during the COVID-19 pandemic. This paper utilizes the Household Pulse Survey, administered by the U.S. Census Bureau throughout the pandemic, to examine the avenues by which COVID-19 impacted Food-Away-From-Home and Food-At-Home expenditures. Additionally, we seek to quantify the effects of factors that are found to have significant effects on food expenditures. This paper incorporates conditional density estimation to examine how the effect of these variables on food expenditures differ across the distribution of food expenditures. Our study contributes to the general body of literature concentrated on identifying the paramount factors that drive food spending. We offer a disaggregated investigation of how food spending changed during COVID-19 in addition to an empirical technique new to the food and agriculture sector of applied economics.
Stress and Coping Mechanisms in Urban Versus Rural Nurses During the COVID-19 Pandemic
Creators: name: Hmiel, Hayden
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: In December of 2019, the COVID-19 virus began to spread across the world. Treating global pandemics is usually assigned to frontline healthcare workers, which is often nurses (Sirois and Owens, 2020). This stress can result in depression, anxiety, post-traumatic scarring, burnout, and suicidal ideation (Sirois and Owens, 2020). The healthcare systems within urban areas versus rural areas are a significant determinant of health outcomes. This research project aimed to examine the differences in how nurses experienced stress and coped within these two types of healthcare systems during the COVID-19 pandemic. A quantitative descriptive analysis was conducted on a cross sectional survey to collect demographic, stress, coping, and adaptive outcomes data. Semi-structured interviews were completed and qualitative description was guided by the Stress and Coping Model developed by (Biggs et al., 2017; Lazarus & Folkman, 1984). The 11 rural participants compared to the 9 urban participants demonstrated significantly more stress (p< .001), depression (p= .001), and somatic symptoms (p< .001). The semi-structured interviews yielded similar themes across the subgroups in regards to their dynamics within the Lazarus and Folkman Stress and Coping Model. This study demonstrated how working during a pandemic can alter the mental and physical health of rural versus urban nurses. The findings of this study provide insight into the efficacy of not only unit and hospital resources, but also different coping mechanisms by nurses. Continued large-scale research into the perspectives of nurses will help our healthcare system best support our nurses grapple with immense stress during future pandemics.
Selaginella P. Beauv., Prodr.
Creators: name: Christenhusz, Maarten J. M.
name: Zhang, Xian-Chun
name: Schneider, Harald
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Lycopodiopsida
Selaginellales
Selaginellaceae
Selaginella

description: 3.1. Selaginella P.Beauv., Prodr. 101 (1805), nom. cons.
T.: Selaginella spinosa P.Beauv., nom. illeg. = S. selaginoides (L.) Link
description: Published as part of Christenhusz, Maarten J. M., Zhang, Xian-Chun & Schneider, Harald, 2011, A linear sequence of extant families and genera of lycophytes and ferns, pp. 7-54 in Phytotaxa 19 on page 41, DOI: 10.11646/phytotaxa.19.1.2, http://zenodo.org/record/4893995
Equisetum C.Linnaeus 1753
Creators: name: Christenhusz, Maarten J. M.
name: Zhang, Xian-Chun
name: Schneider, Harald
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Equisetopsida
Equisetales
Equisetaceae
Equisetum

description: 4.1. Equisetum L., Sp. Pl. 2: 1061 (1753).
T.: Equisetum fluviatile L.
description: Published as part of Christenhusz, Maarten J. M., Zhang, Xian-Chun & Schneider, Harald, 2011, A linear sequence of extant families and genera of lycophytes and ferns, pp. 7-54 in Phytotaxa 19 on page 41, DOI: 10.11646/phytotaxa.19.1.2, http://zenodo.org/record/4893995
What affects women’s career progression in the health sectors in India and Kenya? A scoping review protocol
Creators: name: Odero, Henry Owoko
name: Zeinali, Zahra
name: Buse, Kent
name: Sucharitha Venkatesh
name: Saville, Naomi M
name: Kedia, Sapna
name: Tanaka, Sonja
name: Odunga, Sally Atieno
name: Hawkes, Sarah
name: Muyingo, Sylvia
name: Eleh, Lawrence
name: Koay, Aaron
name: Verma, Ravi
name: Uppal, Radhika
Publisher: name: OSF Registries
Year: 2024
Subjects: subject: Medicine and Health Sciences
subject: Social and Behavioral Sciences
subject: India
subject: Kenya
subject: career
subject: gender equality
subject: health
subject: leadership
subject: nursing
subject: women

description: This is a scoping review protocol. The scoping review aims to explore enablers and barriers to improving equal opportunity and effective organisational interventions that can advance women’s career progression towards leadership in India and Kenya’s health sectors.
ПОРІВНЯЛЬНИЙ АНАЛІЗ ІНСТИТУТУ АДМІНІСТРАТИВНОГО ОСКАРЖЕННЯ В УКРАЇНІ ТА КРАЇНАХ ЄС
Creators: name: Войтовський, В. С.
Publisher: name: Zenodo
Year: 2024
Subjects: ЄС, захист прав і законних інтересів, досудовий порядок, скарга, адміністративна юстиція, правозахисна функція

description: Досудове оскарження дій органів публічної адміністрації покликане забезпечити оперативний захист (відновлення) порушених прав, свобод і законних інтересів у сфері державного управління та звільнити громадян від необхідності звертатися до суду. Одночасно позасудове (адміністративне) оскарження виконує не лише правозахисну функцію — ці досудові процедури є важливим механізмом зворотного зв'язку, що об'єднує громадянське суспільство та інститути публічної влади. Останні завдяки йому мають можливість отримувати інформацію про недоліки в окремих питаннях державного управління та оперативно усувати їх.

Метою статті є вивчення теоретичних засад змісту адміністративно-правового інституту досудового оскарження, а також формулювання практичних пропозицій щодо вдосконалення правового регулювання досудових процедур оскарження. Аналізуючи чинне законодавство України, праці вітчизняних і закордонних науковців, визначено, що досвід країн ЄС свідчить про те, що найвищою формою врегулювання спорів громадян з державними органами є адміністративна юстиція, тобто, установа системи адміністративних судів, у компетенції яких перебуває вирішення спорів адміністративного характеру.  Водночас низка причин (завантаженість судів, взаємне бажання сторін як якомога швидше вирішити спір, фінансові причини) підштовхують до пошуку інших способів вирішення адміністративних спорів. У зазначеній сфері можна виділити два напрямки: традиційне адміністративне оскарження (досудове) та альтернативні способи вирішення спорів.

Дослідження дозволило визначити, що у більшості випадків адміністративне оскарження, так само як і альтернативні процедури у країнах ЄС, обов'язково повинні передувати розгляду справи у суді. Проте ці способи не зможуть замінити собою судовий етап, тобто, суд завжди залишається найвищою інстанцією вирішення адміністративного спору. У висновку наголошено: у системі виконавчого федералізму, встановленого установчими договорами ЄС, саме держави – члени ЄС несуть основну відповідальність за реалізацію законодавства ЄС на національному рівні. Випадки централізованого адміністрування є винятком у ширшій адміністративній структурі ЄС. Крім прямого та непрямого адміністрування, з'являється все більше форм спільного адміністрування, при яких національна влада держав – членів ЄС та органи ЄС співпрацюють з різною інтенсивністю, у різний спосіб при реалізації на практиці законодавства ЄС. Також це твердження стосується їх повноважень у сфері адміністративного оскарження.
Cheiroglossa C. Presl, Suppl. Tent. Pterid.
Creators: name: Christenhusz, Maarten J. M.
name: Zhang, Xian-Chun
name: Schneider, Harald
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Psilotopsida
Ophioglossales
Ophioglossaceae
Cheiroglossa

description: 5.1. Cheiroglossa C.Presl, Suppl. Tent. Pterid. 56 (1845).
T.: Cheiroglossa palmata (L.) C.Presl (Ophioglossum palmatum L.)
description: Published as part of Christenhusz, Maarten J. M., Zhang, Xian-Chun & Schneider, Harald, 2011, A linear sequence of extant families and genera of lycophytes and ferns, pp. 7-54 in Phytotaxa 19 on page 41, DOI: 10.11646/phytotaxa.19.1.2, http://zenodo.org/record/4893995
Separation of Extracellular Vesicle Subpopulations by a Novel Heparin-Based, Large-Scale Purification Protocol
Creators: name: Runjie Yuan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Extracellular vesicles (EVs) are a family of membrane vesicles bound by phospholipid bilayers. Their roles in cell-to-cell communication, cargo transport, and disease biomarkers have gained increasing attention in recent years. However, it remains challenging to categorize and isolate EVs, due to their diverse sizes, origins, and cargo contents. Commonly used methods, such as differential ultracentrifugation, size-exclusion chromatography, and polyethylene-glycol (PEG) precipitation, all have their advantages and limitations. Therefore, it is essential to develop an efficient purification method to isolate exosomes from primary fluids and cell culture conditioned medium. Heparin is an anticoagulant widely used in clinical settings. Previous studies have shown exosomes bind to heparin-conjugated agarose beads. Inspired by the idea, we designed and optimized a novel heparin-based, large-scale purification protocol that identified subpopulations of exosomes. The design was based on a previously developed large-scale purification process, which combined tangential-flow filtration (TFF), PEG precipitation, and Capto Core 700 mixed-mode chromatography to isolate exosomes at high purity. We added one more heparin-based affinity chromatography step to the process. The heparin column separated exosomes into two distinct populations, one that would not bind to the column and remained in the flow-through, and the other that would bind to the column and eluted by buffer with higher salt concentration. The isolated exosomes were biologically active. We also compared the effects of incubation time and exosome concentration on the level of
exosome cell intake. Previous research has shown that annexin V and heparin could inhibit cell intake of exosomes. However, our results reflected little to no such inhibition effects.
Harnessing CD8+ T cell activity for improving adoptive cell therapies in pancreatic cancer
Creators: name: Chong, Kelly
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Cancer immunotherapies have revolutionized the field of oncology. Adoptive cell therapy (ACT) is a specialized immunotherapies wherein T cells are collected from a patient, engineered and expanded in the lab, and thereafter returned to the patient to enhance the immune response against cancer. ACTs have shown remarkable success in treating hematological cancers in the past decade. However, the efficacy of ACTs, including T cells engineered with artificial receptors such as chimeric antigen receptor T cells (CAR-T), in treating solid tumor cancers remains low. Pancreatic ductal adenocarcinoma (PDAC) is a solid malignancy with poor ACT outcomes due to a harsh, immunosuppressive tumor microenvironment (TME) that drives T cell dysfunction or “exhaustion.” In this study, we sought to establish preclinical models for evaluating and manipulating T cell exhaustion in PDAC. By developing new strategies to understand the molecular signals controlling a dysfunctional or an exhausted state, we can begin to genetically engineer T cells for improved ACT efficacy. We have established two clinically relevant models for evaluating ACTs in PDAC, which we seek to leverage for understanding the signals controlling adoptively transferred T cell dysfunction in PDAC tumors. The first model is an engineered T cell receptor (TCR)-T model wherein T cells recognize a tumor antigen through their genetically engineered TCR, and the second model is a previously published CAR-T model wherein T cells recognize tumor-specific surface antigens through their genetically engineered CAR. Future work will leverage these tools to uncover new modes for genetically engineering T cells for improved control of PDAC growth.
RefExpo
Creators: name: haratian, vahid
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 461202
subject: Empirical software engineering

description: Our research introduces RefExpo, an innovative and user-friendly dependency graph (DG) extraction tool designed to support multiple programming languages, including Java and Python. RefExpo is built as an IntelliJ plugin, which allows to utilization the strong indexing engine of IntelliJ.
Botrychium Sw., J. Bot. (Schrader 1800
Creators: name: Christenhusz, Maarten J. M.
name: Zhang, Xian-Chun
name: Schneider, Harald
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Psilotopsida
Ophioglossales
Ophioglossaceae
Botrychium

description: 5.2. Botrychium Sw., J. Bot. (Schrader) 1800 (2): 8 (1801).
T.: Botrychium lunaria (L.) Sw. (Osmunda lunaria L.)
description: Published as part of Christenhusz, Maarten J. M., Zhang, Xian-Chun & Schneider, Harald, 2011, A linear sequence of extant families and genera of lycophytes and ferns, pp. 7-54 in Phytotaxa 19 on page 41, DOI: 10.11646/phytotaxa.19.1.2, http://zenodo.org/record/4893995
Herbivory and Tolerance in Tobacco and Devil's Claw
Creators: name: Pereira, Tyler
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Insect herbivory is a major contributor to overall plant health and reproductive success.
Increases in herbivory can greatly impact the time it takes for a plant to reach maturity, as well as
the amount of seeds that it produces. Tolerance, or the ability of plants to withstand and recover
from insect herbivory, can vary greatly between different species of plants. What is less known,
however, is the relation between leaf damage and the reproductive efficiency of the plant. To
analyze the differing rates of seed pod maturity and seed set size in two species of plants, we
assigned native (tobacco) and non-native (devil’s claw) plants to one of four herbivory treatment
groups. In our research, we examined differences in plant maturity and development based on the
level of herbivory that each plant experienced. Our results did not reflect particularly strong
correlations between herbivory and seed pod maturation, indicating that both plant species were
tolerant of high levels of herbivory. Supplementing these results with additional experiments on
seed set and germination could allow us to track the reproductive success of certain plants in
relation to changing global temperatures and interspecies interactions.
Helminthostachys Kaulf., Enum. Filic.
Creators: name: Christenhusz, Maarten J. M.
name: Zhang, Xian-Chun
name: Schneider, Harald
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Psilotopsida
Ophioglossales
Ophioglossaceae
Helminthostachys

description: 5.3. Helminthostachys Kaulf., Enum. Filic. 28 (1824).
T.: Helminthostachys dulcis Kaulf., nom. illeg. = H. zeylanica (L.) Hook.
description: Published as part of Christenhusz, Maarten J. M., Zhang, Xian-Chun & Schneider, Harald, 2011, A linear sequence of extant families and genera of lycophytes and ferns, pp. 7-54 in Phytotaxa 19 on page 41, DOI: 10.11646/phytotaxa.19.1.2, http://zenodo.org/record/4893995
Mankyua B.-Y.Sun, M.H.Kim & C.H.Kim
Creators: name: Christenhusz, Maarten J. M.
name: Zhang, Xian-Chun
name: Schneider, Harald
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Psilotopsida
Ophioglossales
Ophioglossaceae
Mankyua

description: 5.4. Mankyua B.- Y.Sun, M.H.Kim & C.H.Kim, Taxon 50: 1020 (2002).
T.: Mankyua chejuense B.-Y.Sun, M.H.Kim & C.H.Kim
description: Published as part of Christenhusz, Maarten J. M., Zhang, Xian-Chun & Schneider, Harald, 2011, A linear sequence of extant families and genera of lycophytes and ferns, pp. 7-54 in Phytotaxa 19 on page 41, DOI: 10.11646/phytotaxa.19.1.2, http://zenodo.org/record/4893995
Ophioglossum L.
Creators: name: Christenhusz, Maarten J. M.
name: Zhang, Xian-Chun
name: Schneider, Harald
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Psilotopsida
Ophioglossales
Ophioglossaceae
Ophioglossum

description: 5.5. Ophioglossum L., Sp. Pl. 1062 (1753).
T.: Ophioglossum vulgatum L.
description: Published as part of Christenhusz, Maarten J. M., Zhang, Xian-Chun & Schneider, Harald, 2011, A linear sequence of extant families and genera of lycophytes and ferns, pp. 7-54 in Phytotaxa 19 on page 41, DOI: 10.11646/phytotaxa.19.1.2, http://zenodo.org/record/4893995
Investigation of engineered neural stem cells encapsulated in FLOSEAL® for the post-surgical treatment of ovarian and endometrial cancers
Creators: name: Marand, Michael
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Neural stem cell (NSC) therapy is under investigation as a drug delivery platform for localized treatment of tumors. The persistence of NSCs in the diseased area remains a hindrance to efficacy. It has been demonstrated that FLOSEAL®, an FDA-approved, biocompatible surgical hemostat can be repurposed as a scaffold that extends the persistence of induced neural stem cells by 30 to 60 days in post-surgical mouse models of glioblastoma. In the present study, we investigate the potential of HB1.F3-TK therapeutic neural stem cells encapsulated in FLOSEAL® as a post-surgical treatment for ovarian and endometrial cancers. We demonstrate that HB1.F3-TK cells are capable of significantly killing ES-2 and SKOV-3 ovarian tumor lines and Ishikawa endometrial tumor line in vitro. The compatibility of HB1.F3 with three different densities of FLOSEAL® scaffold is demonstrated. All three formulations of FLOSEAL® scaffold are capable of homogeneously seeding HB1.F3 and maintaining HB1.F3 viability in FLOSEAL® up to 14 days. The medium density formulation of FLOSEAL® improved the persistence of HB1.F3 in vivo 10-fold compared to HB1.F3 in saline. Future studies may investigate the in vivo biodistribution and survival impact of HB1.F3-TK in FLOSEAL® in mouse models for ovarian and endometrial cancer. An effective NSC therapy may help address clinical challenges in post-operative ovarian cancer recurrence and treatment toxicity concerns for subpopulations of endometrial cancer patients with comorbidities.
Analyzing Dynamically Expressed Proteins within the Heart
Creators: name: Aye, Thi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Congenital heart disease (CHD) is one of the most prevalent forms of birth defects caused by various abnormalities during embryonic development. To understand CHD, it is critical to understand the molecular events of embryonic heart development. Our lab used quantitative proteomics to identify proteins within the heart and found that they were essential for embryonic heart development. From this, we identified one pathway of interest, the mevalonate (MVA) pathway. The pathway is involved in many important cellular functions, including cell proliferation, survival, migration, and apoptosis. However, its role in heart development is not fully understood. Our analysis of proteomics data shows that the majority of proteins within this pathway are highly expressed during critical time points in heart development (E12 to E16). Therefore, we hypothesized that this pathway is critical for heart development and alterations in this pathway may lead to CHD. To first assess the role of the MVA pathway in the developing heart, I performed an immunohistological analysis of GGPS1 and HMGCR1, two critical proteins in the pathway. I used fluorescence immunohistochemistry to determine the temporal and spatial expressions of GGPS1 and HMGCR at critical stages of embryonic heart development (E 9.5, E12.5, and E16.5). We found that GGPS1 is expressed in major components of the heart and increases in expression as the heart develops. Our double stain analysis of GGPS1 and Tropomyosin showed that GGPS1 is localized in cardiomyocytes of the major components and trabeculae. HMGCR1 is initially highly expressed in the atria and ventricles but decreases in expression as the heart develops. Given that its proteins are dynamically expressed in the developing heart, we believe that an increased understanding of the MVA pathway will inform developmental abnormalities that contribute to CHD.
In A Paradise Unlimited: Short Stories
Creators: name: Bradley, Savannah
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: IN A PARADISE UNLIMITED is a collection of 12 stories — a magical realist, fabulist story cycle that takes place on (fictional) Half-Moon Island in Brunswick County, off the southeastern coast of North Carolina. Characters weave in and out of these tales, while others stand alone, drawing their own patterns in the sand — about genealogy, family, climate change, and what we owe to each other.
Tmesipteris Bernh., J. Bot. (Schrader 1800
Creators: name: Christenhusz, Maarten J. M.
name: Zhang, Xian-Chun
name: Schneider, Harald
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Psilotopsida
Psilotales
Psilotaceae
Tmesipteris

description: 6.2. Tmesipteris Bernh., J. Bot. (Schrader) 1800 (2): 131 (1801).
T.: Tmesipteris tannensis (Spreng.) Bernh. (Lycopodium tannense Spreng.)
description: Published as part of Christenhusz, Maarten J. M., Zhang, Xian-Chun & Schneider, Harald, 2011, A linear sequence of extant families and genera of lycophytes and ferns, pp. 7-54 in Phytotaxa 19 on page 41, DOI: 10.11646/phytotaxa.19.1.2, http://zenodo.org/record/4893995
Noncanonical Function of G9a in Translational Regulation to Promote Breast Cancer
Creators: name: Silver, Benjamin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and is difficult to treat due to the absence of a target for therapeutics such as estrogen-receptor (ER), progesterone-receptor (PR), and human epidermal growth factor receptor 2 (HER2). The histone methyltransferases G9a and G9a-like protein (GLP; hereafter G9a will represent both proteins) are well-regarded as the transcriptional (epigenetic) silencer of most tumor suppressor genes in breast cancer cells. Strikingly, our lab has recently discovered that, via its interaction with METTL3, a N6-Adenosine-Methyltransferase, G9a plays a noncanonical (non-epigenetic) role in the gene-specific translational regulation under chronic inflammatory conditions. Using our functional chemoproteomic approach (ChaC)1, we also identified METTL3 as a TNBC-specific interactor of G9a, likely because TNBC is a chronic inflammation-associated disease (unpublished). Accordingly, to better understand how G9a promotes breast carcinogenesis, we sought to determine if G9a, through interactions with METTL3, also functions in translational regulation in TNBC cells. Using a TNBC cell line (MDA-MB-231) and translatome proteomics– the proteome-wide analysis of actively translated proteins–we comparably determined global protein turnover in wild-type (WT) cells to both G9a-knockout cells (G9a-KO) and METTL3- knockout cells (METTL3-KO). We showed that METTL3 promotes the turnover of carcinogenesis-related pathways in breast cancer cells. At the time of writing this, we have not yet analyzed G9a-KO cells, but when compared to previously obtained translatome data on G9a- KO and UNC0642 treatment in MDA-MB-231 cells (unpublished), there is overlap between METTL3-regulated and G9a-regulated proteins, indicating shared regulatory mechanisms. Understanding specifically how G9a may coregulate translation of oncogenes through interactions with METTL3 can help to develop effective, targeted therapeutics for TNBC.
Infant Temperament, Socially Aversive Traits, and Maternal Mindfulness
Creators: name: Brady, Mahlon
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Child temperament is shaped by several environmental factors, including how caregivers respond to infant needs. Some caregivers respond to their child with care and consideration, and other caregivers are much less sensitive. For example, mothers who display socially aversive traits are less likely to adequately respond to their infant’s needs. This inadequacy may negatively impact infant temperament. It is possible, however, that mothers’ mindfulness may mitigate any negative impacts. The present study used data from the Brain and Early Experience Study to examine the potential association between maternal socially aversive traits and infant temperament as well as how this association may be moderated my maternal mindfulness. Mothers (N = 153) completed self-assessments prenatally to measure socially aversive traits and mindfulness. When infants were 6 months-old, temperament was evaluated through observation and parent-reports. The temperament traits assessed in this study were social approach, affect, attention, negative affect, surgency, and orienting and regulatory control. Results provide some evidence for a negative relationship between socially aversive traits and infant temperament. There were significant negative associations between Machiavellianism and attention as well as psychopathy and orienting and regulatory control. Results also suggest that mindfulness is protective against the effects of maternal narcissistic tendencies on infant social approach. Therefore, the results of this study have implications for the consideration of mindfulness training for caregivers, as it may ameliorate the negative impacts of certain parental characteristics on child development.
Resistance Mechanisms to the Antibiotic Fluopsin C in Pseudomonas aeruginosa and Escherichia coli
Creators: name: Bryant III, Lacy H
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: The selective pressure of bacterial resistance creates an ever-present need for novel bacterial therapeutics. Fluopsin C is a unique copper-containing natural product produced by Pseudomonas aeruginosa that has broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria. While work in the group has elucidated the biosynthesis of fluopsin C, little is known about the antimicrobial mechanism of fluopsin C and how the producing bacterium P. aeruginosa resists this antimicrobial activity. We hypothesized that MexPQ-OpmE exports fluopsin C as a self-resistance mechanism and discovered that genetic deletion of the intracellular component (MexP or MexQ) of an efflux pump (MexPQ-OpmE) in P. aeruginosa reduces fluopsin C resistance up to 4-fold. This result suggests that MexPQ-OpmE contribute to the self-resistance of fluopsin C. The antimicrobial mechanisms of fluopsin C were investigated in Escherichia coli by raising fluopsin C-resistant mutants. Whole-genome sequencing analysis of the resistant E. coli strains highlights mutations in the 70S ribosome, tRNA-Ala, and CueO, suggesting they are targets for fluopsin C’s mode of action, which adds to the understanding of this promising antibiotic.
Psilotum Sw., J. Bot. (Schrader 1800
Creators: name: Christenhusz, Maarten J. M.
name: Zhang, Xian-Chun
name: Schneider, Harald
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Psilotopsida
Psilotales
Psilotaceae
Psilotum

description: 6.1. Psilotum Sw., J. Bot. (Schrader) 1800 (2): 8 (1801).
T.: Psilotum triquetrum Sw., nom. illeg. = P. nudum (L.) P.Beauv.
description: Published as part of Christenhusz, Maarten J. M., Zhang, Xian-Chun & Schneider, Harald, 2011, A linear sequence of extant families and genera of lycophytes and ferns, pp. 7-54 in Phytotaxa 19 on page 41, DOI: 10.11646/phytotaxa.19.1.2, http://zenodo.org/record/4893995
Chemokine ENA-78/CXCL5 is Produced by OA Synovial Fibroblasts in Response to a Matrix Damage Stimulus and is Found in Synovial Fluid Collected from Patients After ACL Injury
Creators: name: Alberto, Ralph
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Cartilage degradation, the major hallmark of osteoarthritis (OA), is primarily due to the overproduction of secreted matrix metalloproteinases (MMP)s by chondrocytes; however, synoviocytes also contribute to this activity by releasing OA mediators that exacerbate joint destruction. The crosstalk between synovial cells and chondrocytes could be crucial, due to further secretion of key cytokines and chemokines that intensify catabolic signaling and activity in both cell populations. Indeed, synovial fibroblasts have been hypothesized to express cytokines and MMPs in response to matrix protein fragments found in the cartilage and synovium of human OA joints. After treating human osteoarthritic synovial fibroblasts and articular chondrocytes with a fragment of the matrix protein fibronectin (FN-f) found in OA joints, we compared production of MMP-1, MMP-13, and IL-6 from both cell types using immunoblots. Furthermore, we used protein arrays to measure 80 different cytokines/chemokines to map synovial fibroblast’s secretome following FN-f induction. Many cytokines/chemokines were shown to be oversecreted following FN-f treatment, including MCP-1, RANTES, MIP-1 beta, and ENA-78 (CXCL5). We focused specifically on the chemokine ENA-78 (CXCL-5), which had not been previously studied in OA and used an ENA-78 ELISA to quantitate production by synovial fibroblasts and articular chondrocytes. We also examined ENA-78 in synovial fluid from patients who had torn their anterior cruciate ligament (ACL) and noted concentrations varying from less than 10 pg/mL to 1.4 ng/mL. These results significantly correlated with an MRI measure of decreased cartilage proteoglycan density measurements and more severe patient reported Knee Injury and Osteoarthritis Outcome Scores (KOOS) scores. These studies will define a new pathway in OA that could serve as a target for disease modification.
Danaea Sm., Mém. Acad. Roy. Sci. Turin
Creators: name: Christenhusz, Maarten J. M.
name: Zhang, Xian-Chun
name: Schneider, Harald
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Fungi
Tracheophyta
Marattiopsida
Marattiales
Marattiaceae
Danaea

description: 7.1. Danaea Sm., Mém. Acad. Roy. Sci. Turin 5: 420. t. 9, f. 11 (1793), nom. cons.
T.: Danaea nodosa (L.) Sm. (Acrostichum nodosum L.)
description: Published as part of Christenhusz, Maarten J. M., Zhang, Xian-Chun & Schneider, Harald, 2011, A linear sequence of extant families and genera of lycophytes and ferns, pp. 7-54 in Phytotaxa 19 on page 41, DOI: 10.11646/phytotaxa.19.1.2, http://zenodo.org/record/4893995
title: История архитектуры
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2024

description: В учебном пособии изложены основные этапы истории мировой и отечественной архитектуры. Приведены основные художественно-конструктивные направления формообразования в мировой архитектуре. В книге содержится большое количество иллюстраций. Подготовлено в соответствии с Федеральным государственным образовательным стандартом высшего образования. Учебное пособие предназначено для студентов укрупненных групп направлений подготовки «Архитектура», «Техника и технологии строительства», «Культуроведение и социокультурные проекты», изучающих дисциплину «История архитектуры».
And You Will Be a Song (With Selected Enneadic Appositions)
Creators: name: Register, Phillip
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: "And You Will Be a Song" is a novel set in the world of the Ennead - a collection of nine interconnected planets overtly based on historical events and cultures. Its events and characters are an amalgamation of literary-historical accounts: the historical Gempei War (depicted in the literary Heike Monogatari), the Byzantine-Sasanian Wars of the sixth and seventh centuries, the “Flower Wars” of the Aztecs, the wars of the Northern and Southern dynasties, and various other smaller contributions. Our main characters are regular people, thrust into a world chock-full of heroes and historical figures. "Enneadic Appositions" is a collection of short stories set in the time period before the novel.
Ptisana Murdock
Creators: name: Christenhusz, Maarten J. M.
name: Zhang, Xian-Chun
name: Schneider, Harald
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Marattiopsida
Marattiales
Marattiaceae
Ptisana

description: 7.3. Ptisana Murdock, Taxon 57(3): 744 (2008).
T.: Ptisana salicina (Sm.) Murdock (Marattia salicina Sm.)
description: Published as part of Christenhusz, Maarten J. M., Zhang, Xian-Chun & Schneider, Harald, 2011, A linear sequence of extant families and genera of lycophytes and ferns, pp. 7-54 in Phytotaxa 19 on page 41, DOI: 10.11646/phytotaxa.19.1.2, http://zenodo.org/record/4893995
Eupodium J. Sm., J. Bot. (Hooker
Creators: name: Christenhusz, Maarten J. M.
name: Zhang, Xian-Chun
name: Schneider, Harald
Publisher: name: Zenodo
Year: 2011
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Marattiopsida
Marattiales
Marattiaceae
Eupodium

description: 7.2. Eupodium J.Sm., J. Bot. (Hooker) 4: 190 (1841).
T.: Eupodium kaulfussii (J.Sm. ex Hook.) J.Sm. ex Hook. (Marattia kaulfussii J.Sm. ex Hook.)
description: Published as part of Christenhusz, Maarten J. M., Zhang, Xian-Chun & Schneider, Harald, 2011, A linear sequence of extant families and genera of lycophytes and ferns, pp. 7-54 in Phytotaxa 19 on page 41, DOI: 10.11646/phytotaxa.19.1.2, http://zenodo.org/record/4893995