Pattern of Serum Tumour Necrosis Factor, Interleukin 17 And 19, Levels in Young Adult Females with Acne Vulgaris
Creators: name: Emereole C.N
name: Ikaraoha C.I
name: Nwadike C.N
Publisher: name: gjrpublication
Year: 2024

description: Acne is likely to be a genuine chronic inflammatory disease of pilosebaceous unit widely affecting adolescents and young adults. This study was aimed at evaluating the levels of tissue necrosis factor IL-17, IL-19 in female young adult of Imo State University with Acne vulgaris. The study was carried out in Owerri, Imo state. A total of one hundred young female adult was recruited for the study. The 100 subjects were divided into two groups, which were further grouped into mild, moderate and severe Acne vulgaris sufferers. Group 1 consists of 50 female subjects with Acne vulgaris while group 2 consists of 50 female subjects without Acne vulgaris. Five milliliters (5 ml) of blood was then collected into the vaccutainer tube with minimal stasis, the blood was allowed to clot at room temperature, and serum separated and harvested into clean dry well labeled sample bottles following centrifugation at 3000 rpm for 5 minutes. All reagents were commercially purchased and the manufacturer’s standard operational procedures (SOPs) were strictly followed. The result of the test was analyzed using SPSS version 23. There was no significant difference (0.563) in the mean value of serum tissue necroses factor in female student with mild acne (111.33±46.58) pg/ml when compared to control (97.63±46.58) pg/ml.. The mean value of serum IL17 was significantly increased (0.000) in female student with mild acne (125.96±15.71) pg/ml when compared to control (27.23±9.57) pg/ml. The mean value of serum IL19 was significantly increased (0.000) in female student with mild acne (8.87±2.79) pg/ml when compared to control (3.16±1.74) pg/ml.. The mean value of serum TNF was significantly increased (0.015) in female student with moderate acne (143.25±4.24) pg/ml when compared to control (97.63±46.58) pg/ml. The mean value of serum IL17 was significantly increased (0.000) in female student with moderate acne (142.01±16.72) pg/ml when compared to control (27.23±9.57) pg/ml. The mean value of serum IL19 was significantly increased (0.000) in female student with moderate acne (15.11±3.16) pg/ml when compared to control (3.16±1.74) pg/ml. The mean value of serum TNF was significantly increased (0.000) in female student with severe acne (190.15±21.99) pg/ml when compared to control (97.63±46.58) pg/ml. The mean value of serum IL17 was significantly increased (0.000) in female student with severe acne (204.23±20.01) pg/ml when compared to control (27.23±9.57) pg/ml. The mean value of serum IL19 was significantly increased (0.000) in female student with severe acne (22.84±8.36) pg/ml when compared to control (3.16±1.74) pg/ml. There was a non significant positive correlation of TNF with IL17, and IL19 in female students with moderate acne (r=0.27, p=0.560; r=0.25, p=0.593 and r=0.30, p=0.514). There was a non significant negative correlation of TNF with IL17, IL19, total protein and albumin in female students with severe acne (r=-0.24, p=0.562; r=-0.21, p=0.618, r=-0.41, p=0.747 and r=-0.02, p=0.965). Acne vulgaris at different stages of severity in females is associated with significant increase in TNF-α, IL-17 and IL-19. These findings suggest that TNF-α, IL-17 and IL-19 could be used as a laboratory indicator to assess the severity of Acne vulgaris and its tendency to form scars, aiding in disease prognosis.