cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Targeted expansion of low-value care lists towards a high-impact short-list, with modelling
Creators: name: Chalmers, Kelsey
name: Elshaug, Adam
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Public Health
subject: Medicine and Health Sciences
subject: Health Services Research

description: This registration is for stage 2 of our project: developing the definitions for the low-value services nominated by our expert panel on low-value care.
Current approaches used in epidemiologic studies to examine short-term multipollutant air pollution exposures
Creators: name: Luben, Thomas J.
name: Sacks, Jason D.
name: Davalos, Angel D.
name: Herring, Amy H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Air pollution epidemiology traditionally focuses on the relationship between individual air pollutants and health outcomes (e.g., mortality). To account for potential copollutant confounding, individual pollutant associations are often estimated by adjusting or controlling for other pollutants in the mixture. Recently, the need to characterize the relationship between health outcomes and the larger multipollutant mixture has been emphasized in an attempt to better protect public health and inform more sustainable air quality management decisions.
title: MRI Spectrum in post-menopausal bleeding
Creators: name: SETH, ROHIT
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Diagnostic procedure
subject: MR
subject: Genital / Reproductive system female
subject: Cancer

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To aid in the diagnosis of causes of post menopausal bleeding To stage endometrial and cervical tumoursto enable appropriate treatment planning To detect metastatic lymph nodes by...
SN 2014J at M82: I. A middle-class type Ia supernova by all spectroscopic metrics
Creators: name: Galbany, L.
name: Moreno-Raya, M. E.
name: Ruiz-Lapuente, P.
name: Hernández, J. I. González
name: Méndez, J.
name: Vallely, P.
name: Baron, E.
name: Domínguez, I.
name: Hamuy, M.
name: López-Sánchez, A. R.
name: Mollá, M.
name: Catalán, S.
name: Cooke, E. A.
name: Fariña, C.
name: Génova-Santos, R.
name: Karjalainen, R.
name: Lietzen, H.
name: McCormac, J.
name: Riddick, F. C.
name: Rubiño-Martín, J. A.
name: Skillen, I.
name: Tudor, V.
name: Vaduvescu, O.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present the intensive spectroscopic follow up of the type Ia supernova (SN Ia) 2014J in the starburst galaxy M82. Twenty-seven optical spectra have been acquired from January 22nd to September 1st 2014 with the Isaac Newton (INT) and William Herschel (WHT) Telescopes. After correcting the observations for the recession velocity of M82 and for Milky Way and host galaxy extinction, we measured expansion velocities from spectral line blueshifts and pseudo-equivalent width of the strongest features in the spectra, which gives an idea on how elements are distributed within the ejecta. We position SN 2014J in the Benetti (2005), Branch et al. (2006) and Wang et al. (2009) diagrams. These diagrams are based on properties of the Si II features and provide dynamical and chemical information about the SN ejecta. The nearby SN 2011fe, which showed little evidence for reddening in its host galaxy, is shown as a reference for comparisons. SN 2014J is a border-line object between the Core-normal (CN) and Broad-line (BL) groups, which corresponds to an intermediate position between Low Velocity Gradient (LVG) and High Velocity Gradient (HVG) objects. SN 2014J follows the R(Si II)-Δm15 correlation, which confirms its classification as a relatively normal SN Ia. Our description of the SN Ia in terms of the evolution of the pseudo-equivalent width of various ions as well as the position in the various diagrams put this specific SN Ia into the overall sample of SN Ia.
description: 14 pages, 10 Figures, 4 Tables. Accepted in MNRAS
title: An Audit of the quality of portable chest x-rays for nasogastric tube placement; changing current practice.
Creators: name: Culleton, Sinead
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Audit and standards
subject: Conventional radiography
subject: Gastrointestinal tract
subject: Abdomen
subject: Swallowing disorders

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: There are many clinically significant benefits to enteral feeding. Nasoenteric feeding is the most widely used method of enteral feeding. It has been proven that enteral feeding helps maintain gastrointestinal integrity, reduces bacterial...
title: Effective dose and effective risk from supplementary imaging of the lumbar spine following radioisotope bone scan: a phantom study
Creators: name: Hogg, Peter
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Dosimetry
subject: SPECT-CT
subject: CT
subject: Conventional radiography
subject: Nuclear medicine
subject: Dosimetric comparison

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: To measure compare the organ and effectice dose from three imaging techniques that are used to supplement isotope bone scanning. To calculate the additional organ and effective doses compared to the bone scan To calculate and compare the effective...
title: Comparison of T2 Weighted Images/ Diffusion Weighted Imaging andT2 Weighted Images/ Dynamic Contrast Enhanced MRI for assessing the depth of myometrial invasion in endometrial cancer
Creators: name: Mourad, Mohamed
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Genital / Reproductive system female
subject: Oncology
subject: Contrast agents
subject: MR
subject: MR-Diffusion/Perfusion
subject: MR-Functional imaging
subject: Observer performance
subject: Contrast agent-other
subject: Cancer
subject: Pathology

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The aim of this study was to evaluate the accuracy of combined T2 and DWI in comparison to combined T2WI and dynamic contrast enhanced MRI aiming for assessment of the myometrial invasion depth in preoperative staging using the histopathological...
Consumption of peanuts and peanut butter on non-communicable diseases and mortality: review systematic and meta-analysis
Creators: name: Hurtado Barroso, Sara
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: Clinical trial
subject: Epidemiology
subject: Nutrition

description: How affect the consumption of peanuts and peanut butter on health-related biomarkers
title: Imaging features of an unclear pathology of the breast: the stromal fibrosis
Creators: name: Dridi, Mouna
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Breast
subject: Elastography
subject: Mammography
subject: Ultrasound
subject: Biopsy
subject: Surgery
subject: Neoplasia
subject: Tissue characterisation

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Focal fibrosis of the breast is a histopathologic entity characterized by proliferation of the stromal connective tissue with obliteration of the mammary ducts and lobules by hypocellular fibrous tissue (Fig 1). (1) This entity has been described by...
Genetic polymorphisms of phase I metabolizing enzyme genes, their interaction with lifetime grilled and smoked meat intake, and breast cancer incidence
Creators: name: Teitelbaum, Susan L.
name: Santella, Regina M.
name: Steck, Susan E.
name: Neugut, Alfred I.
name: Parada, Humberto
name: Cleveland, Rebecca J.
name: Gammon, Marilie D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: To examine associations between 22 CYP single nucleotide polymorphisms (SNPs) and breast cancer incidence and their interactions with grilled–smoked meat intake, a source of polycyclic aromatic hydrocarbons.
Monochromatic neutrino lines from sneutrino dark matter
Creators: name: Arina, Chiara
name: Kulkarni, Suchita
name: Silk, Joseph
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We investigate the possibility of observing monochromatic neutrino lines originating from annihilation of dark matter. We analyse several astrophysical sources with overdensities of dark matter that can amplify the signal. As a case study, we consider mixed left and right handed sneutrino dark matter. We demonstrate that in the physically viable region of the model, one can obtain a prominent monochromatic neutrino line. We propose a search strategy to observe these neutrino lines in future generations of neutrino telescopes that is especially sensitive to dwarf spheroidal galaxies. We demonstrate that the presence of massive black holes in the cores of dwarfs as well as of more massive galaxies substantially boosts any putative signal. In particular, dark matter in dwarf galaxies spiked by IMBH provides a powerful means of probing low annihilation cross-sections well below $10^{-26} \rm cm^3 s^{-1}$ that are otherwise inaccessible by any future direct detection or collider experiment.
description: 17 pages, 10 figures
Addiction recovery and the role of therapeutic alliance in treatment
Creators: name: Tom, Matthew
name: Wong, Ryan
name: Chan, Elda
name: Ching, Fung
name: Shaffer, Howard
name: Grossman, Alessandra
name: LaRaja, Alexander
name: Amichia, Karen
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Substance Abuse and Addiction
subject: Psychiatric and Mental Health
subject: Medicine and Health Sciences
subject: Mental and Social Health
subject: Addiction
subject: Hong Kong
subject: Syndrome Model
subject: Therapeutic Alliance
subject: Treatment Seekers

description: See the attached document "Wong-TherapeuticAlliancePreReg20200515.pdf" for the registration of this project.
title: Imaging in von Hippel Lindau disease: why, when and how
Creators: name: Pjević, Sašo
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Education and training
subject: Embolisation
subject: Education
subject: Diagnostic procedure
subject: MR
subject: CT
subject: Catheter arteriography
subject: Interventional vascular
subject: CNS
subject: Abdomen

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To emphasize importance (why) of radiological imaging in (when) establishing diagnosis, surveillance and therapy of von Hippel Lindau (VHL) disease. To illustrate and review radiological features of VHL disease with different imaging techniques...
Using residential segregation to predict colorectal cancer stage at diagnosis: two different approaches
Creators: name: Scott, Lia
name: Kuo, Tzy-Mey
name: Mobley, Lee R.
name: Rutherford, Yamisha
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Studies have found a variety of evidence regarding the association between residential segregation measures and health outcomes in the US. Some have focused on any individuals living in residentially segregated places, while others have examined whether persons of specific races or ethnicities living in places with high segregation of their own race or ethnicity have differential outcomes. This paper compares and contrasts these two approaches in the study of predictors of late-stage CRC diagnoses in a cross-national study. We argue that it is very important when interpreting results from studies like this to carefully consider the geographic scope of the analysis, which can significantly change the context and meaning of the results.
Improving Applicant Reactions to Forced-Choice Personality Measures by Facilitating Internalisation: A Self-Determination Theory Approach
Creators: name: Dunlop, Patrick
name: Borman, Tristan
name: Gagné, Marylène
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Industrial and Organizational Psychology
subject: Personality and Social Contexts
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: In this study, we aim to examine, experimentally, whether adding either one of two design features to a forced-choice personality assessment improves applicants' perceptions of self-determination need-support (specifically, autonomy and competence) of respondents. In a simulated job application experiment (i.e. where participants are asked to imagine completing a personality questionnaire for a job application), participants will be assigned to complete a forced choice (FC) personality questionnaire under four conditions, or a Likert personality questionnaire in the fifth. Two of the four FC conditions (the control conditions) will replicate a typical FC experience. In one of these, an extra filler task is also presented to participants. In the other two (experimental) conditions, participants will be informed that they will be given the chance to make some final responses or clarifications about their personality after completing the FC personality questionnaire. In one of these, participants will be able to write some additional statements in a free format, and in the other, participants will be given a fixed format to clarify their personality. We will measure all participants' self-reported autonomy, competence and relatedness (for exploratory purposes) needs support.
title: The Radiologist Facing The Dark Side Of The Silicone
Creators: name: Ugarte, Ane
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Foreign bodies
subject: Diagnostic procedure
subject: Ultrasound
subject: MR
subject: CT
subject: Musculoskeletal soft tissue
subject: Lymph nodes
subject: Breast

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Review the radiological features of...
ALMA resolves extended star formation in high-z AGN host galaxies
Creators: name: Harrison, C. M.
name: Simpson, J. M.
name: Stanley, F.
name: Alexander, D. M.
name: Daddi, E.
name: Mullaney, J. R.
name: Pannella, M.
name: Rosario, D. J.
name: Smail, Ian
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present high resolution (0.3") Atacama Large Millimeter Array (ALMA) 870um imaging of five z~1.5-4.5 X-ray detected AGN with luminosities of L(2-8keV)>10^42 erg/s. These data provide a >~20x improvement in spatial resolution over single-dish rest-frame FIR measurements. The sub-millimetre emission is extended on scales of FWHM~0.2"-0.5", corresponding to physical sizes of 1-3 kpc (median value of 1.8 kpc). These sizes are comparable to the majority of z=1-5 sub-millimetre galaxies (SMGs) with equivalent ALMA measurements. In combination with spectral energy distribution analyses, we attribute this rest-frame far-infrared (FIR) emission to dust heated by star formation. The implied star-formation rate surface densities are ~20-200 Mo/yr/kpc^2, which are consistent with SMGs of comparable FIR luminosities (i.e., L(IR)~[1-5]x10^(12)Lo). Although limited by a small sample of AGN, which all have high FIR luminosities, our study suggests that the kpc-scale spatial distribution and surface density of star formation in high-redshift star-forming galaxies is the same irrespective of the presence of X-ray detected AGN.
description: Accepted for publication in MNRAS. 5 pages, 3 figures
Auditable and performant Byzantine consensus for permissioned ledgers
Creators: name: Shamis, Alexander
Publisher: name: Imperial College London
Year: 2022

description: Permissioned ledgers allow users to execute transactions against a data store, and retain proof of their execution in a replicated ledger. Each replica verifies the transactions’ execution and ensures that, in perpetuity, a committed transaction cannot be removed from the ledger. Unfortunately, this is not guaranteed by today’s permissioned ledgers, which can be re-written if an arbitrary number of replicas collude. In addition, the transaction throughput of permissioned ledgers is low, hampering real-world deployments, by not taking advantage of multi-core CPUs and hardware accelerators. This thesis explores how permissioned ledgers and their consensus protocols can be made auditable in perpetuity; even when all replicas collude and re-write the ledger. It also addresses how Byzantine consensus protocols can be changed to increase the execution throughput of complex transactions. This thesis makes the following contributions: 1. Always auditable Byzantine consensus protocols. We present a permissioned ledger system that can assign blame to individual replicas regardless of how many of them misbehave. This is achieved by signing and storing consensus protocol messages in the ledger and providing clients with signed, universally-verifiable receipts. 2. Performant transaction execution with hardware accelerators. Next, we describe a cloud-based ML inference service that provides strong integrity guarantees, while staying compatible with current inference APIs. We change the Byzantine consensus protocol to execute machine learning (ML) inference computation on GPUs to optimize throughput and latency of ML inference computation. 3. Parallel transactions execution on multi-core CPUs. Finally, we introduce a permissioned ledger that executes transactions, in parallel, on multi-core CPUs. We separate the execution of transactions between the primary and secondary replicas. The primary replica executes transactions on multiple CPU cores and creates a dependency graph of the transactions that the backup replicas utilize to execute transactions in parallel.
Push button reproduction attempt of a research claim from Savani, K., Markus, H. R., Naidu, N. V. R., Kumar, S., & Berlia, N. (2010) in Psychological Science
Creators: name: Talbert, Eli
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences

description: We selected the study 3 claim that Americans tend to construe more of another actor’s actions as choices than do Indian participants; Americans therefore identify more instances in a video as times when the actor made a choice. This reflects the following statement from the paper's abstract: "[W]e found that people in U.S. American contexts, where the disjoint model of agency is prevalent, are more likely than those in Indian contexts to construe … other individuals’ behaviors as choices" This claim was tested in Study 3 by submitting the number of button presses made by participants in either a control condition (pressing a button every time the actor touches an object with his hands) or the construal-of-choice condition (pressing a bottom whenever the actor made a choice) to a 2 (culture) × 2 (condition) ANOVA. This analysis yielded an interaction between culture (Indian, American) and condition (construal-of-choice vs. control task) in how often participants pressed the response button, F(1, 120) = 5.69, p < .02, p_rep = .96 The focal test in the original paper is: an interaction between culture (Indian, American) and condition (construal-of-choice vs. control task) in how often participants pressed the response button, F(1, 120) = 5.69, p < .02, p_rep = .96
Software: snow profile basic tools
Creators: name: Herla, Florian
name: Mair, Patrick
name: Horton, Simon
name: Haegeli, Pascal
Publisher: name: Open Science Framework
Year: 2022

description: This component contains a copy of the R-package `sarp.snowprofile` (v0.1.0), which is available from the SFU Avalanche Research Program bitbucket repository https://bitbucket.org/sfu-arp/sarp.snowprofile/src/v0.1.0/
suppData1-OGs.txtMassive Lateral Gene Transfer of genes involved in carbohydrate metabolism on the Contribution of Lateral Gene Transfer to the evolution of the eukaryotic fungus Piromyces sp. strain E2
Creators: name: Duarte, Isabel
name: Huynen, Martijn A.
Publisher: name: figshare
Year: 2018
Subjects: Phylogeny and comparative analysis

description: Lateral Gene Transfer candidate set: Hydrogenosomal protein prediction. Set of predicted hydrogenosomal proteins that are candidates to have been horizontally transferred from Bacteria to the eukaryote Piromyces sp.
title: Abnormalities of the mitral valve and the papillary muscle in primitive hypertrophic cardiomyopathy
Creators: name: Ben Amara, Imen
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Hyperplasia / Hypertrophy
subject: Diagnostic procedure
subject: MR
subject: Cardiac

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Several abnormalities of the mitral valve (MV) and the papillary muscles have been described in patients with hypertrophic cardiomyopathy (HCM). Knowledge of these abnormalities is expanding thanks to the emergence of new imaging techniques...
Substellar Objects in Nearby Young Clusters (SONYC) IX: The planetary-mass domain of Chamaeleon-I and updated mass function in Lupus-3
Creators: name: Muzic, Koraljka
name: Scholz, Alexander
name: Geers, Vincent C.
name: Jayawardhana, Ray
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Substellar Objects in Nearby Young Clusters -- SONYC -- is a survey program to investigate the frequency and properties of substellar objects in nearby star-forming regions. We present new spectroscopic follow-up of candidate members in Chamaeleon-I (~2 Myr, 160 pc) and Lupus 3 (~1 Myr, 200 pc), identified in our earlier works. We obtained 34 new spectra (1.5 - 2.4 mum, R~600), and identified two probable members in each of the two regions. These include a new probable brown dwarf in Lupus 3 (NIR spectral type M7.5 and Teff=2800 K), and an L3 (Teff=2200 K) brown dwarf in Cha-I, with the mass below the deuterium-burning limit. Spectroscopic follow-up of our photometric and proper motion candidates in Lupus 3 is almost complete (>90%), and we conclude that there are very few new substellar objects left to be found in this region, down to 0.01 - 0.02 MSun and Av \leq 5. The low-mass portion of the mass function in the two clusters can be expressed in the power-law form dN/dM \propto M^{-α}, with α~0.7, in agreement with surveys in other regions. In Lupus 3 we observe a possible flattening of the power-law IMF in the substellar regime: this region seems to produce fewer brown dwarfs relative to other clusters. The IMF in Cha-I shows a monotonic behavior across the deuterium-burning limit, consistent with the same power law extending down to 4 - 9 Jupiter masses. We estimate that objects below the deuterium-burning limit contribute of the order 5 - 15% to the total number of Cha-I members.
description: Accepted for publication by Astrophysical Journal
Cost-effectiveness of anlotinib vs. pembrolizumab and nivolumab as third-line treatment in recurrent small cell lung cancer in China
Creators: name: Fei, Zhengyang
name: Rui, Mingjun
name: Wang, Yingcheng
name: Ma, Aixia
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: The study aims to evaluate the cost-effectiveness of anlotinib versus pembrolizumab and nivolumab as the third-line treatment in recurrent small cell lung cancer (SCLC) patients from the Chinese healthcare system perspective. A Markov model was built to simulate the costs and health outcomes in the 4-year horizon. Efficacy and safety data of anlotinib, pembrolizumab, and nivolumab in patients with recurrent SCLC were derived from three studies. Cost and utility values were derived from local charges, the published literature, and related databases. Three scenario analyses and sensitivity analyses were performed to explore the robustness of the results. Compared with anlotinib, pembrolizumab and nivolumab were estimated to gain an additional 0.18 and 0.10 quality-adjusted life years (QALYs) at an incremental cost of $10,446 and $5,182, resulting in an increment cost-utility ratio (ICUR) of $58,221/QALY and $56,733/QALY. The sensitivity analyses showed that the likelihood of anlotinib being cost-effective was 87.5% to 99.9% at a willingness-to-pay (WTP) threshold of $11,144 to $33,431/QALY. The scenario analyses indicated that the results varied in different scenarios. The findings suggest that anlotinib could be the most cost-effective option versus pembrolizumab and nivolumab in the third-line treatment of recurrent SCLC from the Chinese healthcare system perspective.
Zwischen Selbstverwirklichungsutopien und Solidargemeinschaft
Creators: name: Langendörfer, Hans
name: Siebenmorgen, Peter
Publisher: name: Herder Korrespondenz
Year: 1970

description: Herder Korrespondenz, Bd. 44 Nr. 3 (1990): Herder Korrespondenz, Band 44, Heft 3
The Spectroscopic Properties of Lyα-Emitters at z $\approx$ 2.7: Escaping Gas and Photons from Faint Galaxies
Creators: name: Trainor, Ryan F.
name: Steidel, Charles C.
name: Strom, Allison L.
name: Rudie, Gwen C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present a spectroscopic survey of 318 faint $(R\sim 27$, $L\sim0.1L_*)$, Lyα-emission-selected galaxies (LAEs) at 2.5 v_{esc}$.
Systemwandel in der Sowjetunion: Chancen, Grenzen, Gegenkräfte
Creators: name: Leonhard, Wolfgang
Publisher: name: Herder Korrespondenz
Year: 1970

description: Herder Korrespondenz, Bd. 44 Nr. 3 (1990): Herder Korrespondenz, Band 44, Heft 3
Harnessing Information Technology to Inform Patients Facing Routine Decisions: Cancer Screening as a Test Case
Creators: name: Krist, Alex H.
name: Hochheimer, Camille
name: Tu, Shin-Ping
name: Lafata, Jennifer Elston
name: Etz, Rebecca S.
name: Kashiri, Paulette
name: Jones, Resa M.
name: Woolf, Steven H.
name: Sabo, Roy T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Technology could transform routine decision making by anticipating patients’ information needs, assessing where patients are with decisions and preferences, personalizing educational experiences, facilitating patient-clinician information exchange, and supporting follow-up. This study evaluated whether patients and clinicians will use such a decision module and its impact on care, using 3 cancer screening decisions as test cases.
A cross-country utilization patterns comparison of high expenditure therapeutic groups between Portugal and six European countries: the two sides of the Portuguese coin
Creators: name: Martinho, Inês
name: Rodrigues, António Teixeira
name: Guerreiro, José
name: Rocha, João
name: Sepodes, Bruno
name: Torre, Carla
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy

description: Understanding variability in prescribing patterns through comparative drug utilization studies can contribute to improve an efficient, effective and safe use of medicines. To perform a cross-country comparison of consumption patterns of ambulatory high expenditure therapeutic groups between Portugal and six European countries and simulate potential cost-saving scenarios through the adoption of the different prescribing patterns of studied countries. Cross-country comparison of 2019 drug consumption patterns between Portugal, Denmark, England, Finland, the Netherlands, Norway, and Spain. Analysis comprised antihypertensive drugs, glucose lowering drugs (GLD), insulins, lipid lowering drugs (LLD) and oral anticoagulants. Cost-saving analysis were performed using the Portugal average annual cost/daily defined dose and the potential reduction in expenditure simulating other European countries consumption pattern scenarios. Portugal had the lowest consumption uptake of metformin and the highest consumption of GLD (30.1%) and LLD (8.5% vs <3%) fixed-dose combinations. Annual cost-savings scenarios showed that Portugal would have saved between 53 M€ and 305 M€ if it had the same prescribing patterns than Norway or the Netherlands, respectively. Different utilization patterns across countries were found. Although Portugal has the lowest gross domestic product per capita among the countries studied, it had the highest uptake of newly and costly drugs.
title: Spinal involvement in mucopolysaccharidoses: what radiologists need to know
Creators: name: Semprini, Alessia
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Connective tissue disorders
subject: Congenital
subject: Imaging sequences
subject: MR
subject: Digital radiography
subject: CT
subject: Musculoskeletal spine
subject: Musculoskeletal system
subject: Musculoskeletal bone

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The purpose of this educational exhibit was to provide the relevant radiological semiotics that radiologists need to know in the interest of the management of spinal involvement in mucopolysaccharidoses...
The Impact of Facial Expressions and Alexithymia on Decision-making
Creators: name: Undersun, Raven
name: Shore, Danielle
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: A psychological experiment testing the relationship between alexithymia and trust based on the genuineness of facial expressions as measured in an economic game.
International comparability of reference unit costs of education services: when harmonizing methodology is not enough (PECUNIA project)
Creators: name: Pokhilenko, I.
name: Kast, T.
name: Janssen, L.M.M.
name: Evers, S.M.A.A
name: Paulus, A.T.G
name: Simon, J.
name: Mayer, S.
name: Berger, M.
name: Konnopka, A.
name: Muntendorf, L.
name: Brodszky, V.
name: García-Pérez, L.
name: Park, A.
name: Salvador-Carulla, L.
name: Drost, R.M.W.A.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Health problems can lead to costs in the education sector. However, these costs are rarely incorporated in health economic evaluations due to the lack of reference unit costs (RUCs), cost per unit of service, of education services and of validated methods to obtain them. In this study, a standardized unit cost calculation tool developed in the PECUNIA project, the PECUNIA RUC Template for services, was applied to calculate the RUCs of selected education services in five European countries. The RUCs of special education services and of educational therapy were calculated using the information collected via an exploratory gray literature search and contact with service providers. The RUCs of special education services ranged from €55 to €189 per school day. The RUCs of educational therapy ranged from €6 to €25 per contact and from €5 to €35 per day. Variation was observed in the type of input data and measurement unit, among other. The tool helped reduce variability in the RUCs related to costing methodology and gain insights into other aspects that contribute to the variability (e.g. data availability). Further research and efforts to generate high quality input data are required to reduce the variability of the RUCs.
NLO+NLL squark and gluino production cross-sections with threshold-improved parton distributions
Creators: name: Beenakker, Wim
name: Borschensky, Christoph
name: Krämer, Michael
name: Kulesza, Anna
name: Laenen, Eric
name: Marzani, Simone
name: Rojo, Juan
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We present updated predictions for the cross-sections for pair production of squarks and gluinos at the LHC Run II. First of all, we update the calculations based on NLO+NLL partonic cross-sections by using the NNPDF3.0NLO global analysis. This study includes a full characterization of theoretical uncertainties from higher orders, PDFs and the strong coupling. Then, we explore the implications for this calculation of the recent NNPDF3.0 PDFs with NLO+NLL threshold resummation. We find that the shift in the results induced by the threshold-improved PDFs is within the total theory uncertainty band of the calculation based on NLO PDFs. However, we also observe that the central values of the cross-sections are modified both in a qualitative and a quantitative way, illustrating the relevance and impact of using threshold-improved PDFs together with resummed partonic cross-sections. The updated NLO+NLL cross-sections based on NNPDF3.0NLO are publicly available in the NLL-fast format, and should be an important ingredient for the interpretation of the searches for supersymmetric particles at Run II.
description: 23 pages, 8 figures. The updated NLL-fast grids with NNPDF3.0NLO can be obtained from http://pauli.uni-muenster.de/~akule_01/nllwiki/index.php/NLL-fast. Accepted for publication in EPJC
title: Differentiation of hemangioblastomas from pilocytic astrocytomas using perfusion-weighted MR imaging.
Creators: name: Neska-Matuszewska, Malgorzata
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: CNS
subject: Neuroradiology brain
subject: Oncology
subject: MR
subject: MR-Diffusion/Perfusion
subject: Diagnostic procedure
subject: Comparative studies
subject: Neoplasia

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Hemangioblastomas and pilocytic astrocytomas (PAs) are two types of brain tumors that present similar imaging findings, especially when appearing as a large cystic mass in the cerebellum with a mural nodule [1,2]. Hemangioblastomas are observed...
Negative Differential Resistance in Boron Nitride Graphene Heterostructures: Physical Mechanisms and Size Scaling Analysis
Creators: name: Zhao, Y.
name: Wan, Z.
name: Xu, X.
name: Patil, S. R.
name: Hetmaniuk, U.
name: Anantram, M. P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Hexagonal boron nitride (hBN) is drawing increasing attention as an insulator and substrate material to develop next generation graphene-based electronic devices. In this paper, we investigate the quantum transport in heterostructures consisting of a few atomic layers thick hBN film sandwiched between graphene nanoribbon electrodes. We show a gate-controllable vertical transistor exhibiting strong negative differential resistance (NDR) effect with multiple resonant peaks, which stay pronounced for various device dimensions. We find two distinct mechanisms that are responsible for NDR, depending on the gate and applied biases, in the same device. The origin of first mechanism is a Fabry-Pé like interference and that of the second mechanism is an in-plane wave vector matching when the Dirac points of the electrodes align. The hBN layers can induce an asymmetry in the current-voltage characteristics which can be further modulated by an applied bias. We find that the electron-phonon scattering introduces the decoherence and therefore suppresses first mechanism whereas second mechanism remains relatively unaffected. We also show that the NDR features are tunable by varying device dimensions. The NDR feature with multiple resonant peaks, combined with the ultrafast tunneling speed provides prospect for the graphene-hBN-graphene heterostructure in the high-performance electronics.
Professional Codes of Ethics: A Scoping Review
Creators: name: Williams, Brett
name: Collings-Hughes, Derek
name: Townsend, Ruth
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: Code of Conduct; Scoping Review

description: This review uses a scoping review method to identify what is known about health professionals’ knowledge, awareness and use of their professional codes.
A cost-effectiveness analysis of pharmacotherapy versus prostatic urethral lift as initial therapy for patients with moderate benign prostatic hyperplasia
Creators: name: Tung, Joshua YM
name: Aslim, Edwin J
name: Ho, Henry SS
name: Chen, Cynthia
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: Plant Biology

description: The objective of this study was to evaluate the cost-effectiveness of an upfront minimally invasive surgical procedure, the prostatic urethral lift (PUL), as an initial treatment for patients with moderate benign prostatic hyperplasia (BPH), against current first-line pharmacotherapy with combination medical therapy. A micro-simulation model was developed using TreeAge Pro to compare two treatment strategies – initial treatment with combination medical therapy (alpha-blocker + 5-ARI) versus an upfront prostatic urethral lift procedure. The impact on disease progression, costs, and quality-adjusted life-years (QALYs) was analyzed. A Markov model and probabilistic sensitivity analysis were used to estimate the costs and effects of the different strategies. The cost-effectiveness of the strategies at different willingness-to-pay (WTP) thresholds was then examined. Incremental costs (versus no prostatic urethral lift) were S$13,600 (1 year) and S$8,700 (5 years). Incremental QALYs were 0.07 (1 year) and 0.22 (5 years). An upfront PUL procedure was more expensive but also more effective than pharmacotherapy, with an incremental cost per QALY gain of approximately S$39,400. It is a cost-effective treatment option at the willingness-to-pay threshold of S$50,000. Prostatic urethral lift is a cost-effective initial treatment option for men with moderate symptoms of benign prostatic hyperplasia.
title: Radar imaging of breast lesions – a clinical evaluation and comparison
Creators: name: Shere, Mike
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Breast
subject: Experimental
subject: Mammography
subject: Ultrasound
subject: Technology assessment
subject: Equipment
subject: Computer Applications-3D
subject: Cancer

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Imaging of the breast exploits a number of different physical properties of breast tissue such as electron density or acoustic impedance. Dielectric property, which determines propagation and absorption of radio waves, similarly varies in different...
A Systems Toxicology-based Approach Reveals Biological Pathways Dysregulated by Prenatal Arsenic Exposure
Creators: name: Fry, Rebecca C.
name: Laine, Jessica E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Prenatal exposure to inorganic arsenic (iAs) is associated with dysregulated gene and protein expression in the fetus, both evident at birth. Potential epigenetic mechanisms that underlie these changes include but are not limited to the methylation of cytosines (CpG).
New members of the TW Hydrae Association and two accreting M-dwarfs in Scorpius-Centaurus
Creators: name: Murphy, Simon J.
name: Lawson, Warrick A.
name: Bento, Joao
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We report the serendipitous discovery of several young mid-M stars found during a search for new members of the 30-40 Myr-old Octans Association. Only one of the stars may be considered a possible Octans(-Near) member. However, two stars have proper motions, kinematic distances, radial velocities, photometry and Li I 6708AA measurements consistent with membership in the 8-10 Myr-old TW Hydrae Association. Another may be an outlying member of TW Hydrae but has a velocity similar to that predicted by membership in Octans. We also identify two new lithium-rich members of the neighbouring Scorpius-Centaurus OB Association (Sco-Cen). Both exhibit large 12 and 22 micron excesses and strong, variable H-alpha emission which we attribute to accretion from circumstellar discs. Such stars are thought to be incredibly rare at the ~16 Myr median age of Sco-Cen and they join only one other confirmed M-type and three higher-mass accretors outside of Upper Scorpius. The serendipitous discovery of two accreting stars hosting large quantities of circumstellar material may be indicative of a sizeable age spread in Sco-Cen, or further evidence that disc dispersal and planet formation time-scales are longer around lower-mass stars. To aid future studies of Sco-Cen we also provide a newly-compiled catalogue of 305 early-type Hipparcos members with spectroscopic radial velocities sourced from the literature.
description: 12 pages. Accepted for publication in MNRAS
The impact of statistical properties of incremental monetary net benefit and incremental cost-effectiveness ratio on health economic modeling choices
Creators: name: Yuan, Fei
name: Bangdiwala, Shrikant I.
name: Tong, Wesley
name: Lamy, Andre
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: Science Policy

description: There is controversy on whether to use incremental monetary net benefit (INMB) or incremental cost-effectiveness ratio (ICER) in health economic evaluations alongside randomized controlled trials. We studied the impact of restricted mean survival time (RMST) on the long-term projection of INMB and ICER. We analyzed the unbiasedness and efficiency of ICER and INMB by (1) deriving the metrics' expected values and variances based on theoretical probability distributions, (2) simulating their 15-year post-trial projections based on between-arm-RMST-gained through a 2 × 4 × 2 factorial experiment of Markov 2-state microsimulations. Simulations and comparison were run on the data from the Cardiovascular Outcomes for People Using Anticoagulation Strategies Study (COMPASS). Our simulation findings using RMST showed that ICER was more efficient than INMB, regardless of disease populations, time horizon, modeling choices, and underlying probability distributions of incremental mean cost and effect. ICER had a small variance and thus showed its robustness to the choices of models. INMB is unbiased, while ICER is biased-but-remediable. INMB’s variance varies with a willingness-to-pay (WTP) threshold value quadratically while ICER’s variance varies with incremental-mean-cost quadratically. A simple and naïve model can sufficiently estimate ICER. Future metrics are expected to be health-economic-meaningful, unambiguous, unbiased, efficient, and statistical-inference-friendly.
title: Male Breast Disease: a Review of Radiologic Assessment and Accuracy, and Pathologic Variables over the past thirteen years
Creators: name: Greenlaw, Kristin
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Quality assurance
subject: Epidemiology
subject: Cancer
subject: Audit and standards
subject: Ultrasound
subject: Mammography
subject: Breast

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Male breast disease is an often under recognized disease entity party due to its rarity and also to a lack of awareness [1]. Although male breast disease is most often benign, cancer of the vestigial male breast may occur. Currently, breast cancer...
title: MRI in paediatric musculoskeletal infections: the effect of pre-operative imaging on positive microbiological tissue samples.
Creators: name: Procter, Alexander
Publisher: name: European Congress of Radiology
Year: 2016
Subjects: subject: Infection
subject: Surgery
subject: MR
subject: Paediatric
subject: Musculoskeletal system

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Paediatric musculoskeletal (MSK) infections have the potential to cause severe and lifelong morbidity 1 . Fast diagnosis and treatment is therefore critical in improving outcome 2 . As part of their work up most children with a suspected...
Trials Transparency at UK Public Research Institutions
Creators: name: DeVito, Nicholas
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences
subject: Public Affairs, Public Policy and Public Administration
subject: Health Policy
subject: Social and Behavioral Sciences
subject: Bioethics and Medical Ethics
subject: clinical trials
subject: policy
subject: qualitative
subject: research intergirty
subject: trial registration
subject: trial reporting
subject: trials transparency
subject: UK research

description: This study aims to understand how UK public research institutions are managing their trials transparency responsibilities. Through interviews with various personnel related to clinical research integrity, governance and conduct, we will examine what policies and procedures exist at these institutions and how they are implemented in practice. We aim to understand how personnel from various levels of these organisations are engaging with these processes and what changes have been implemented and are to come as the landscape evolves. Understanding the barriers and best practices across these institutions will allow for key insights that can be shared throughout the community to elevate practice and policy recommendations that can look to address some of the largest impediments to complete and timely registration and reporting of clinical trials. The full protocol for this project is included in the Registration as a document attachment. This study was registered prior to first data collection.