cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Diabetes is associated with increased mortality and disease severity in hospitalized patients with COVID-19
Creators: name: Moghaddam Tabrizi, Fatemeh
name: Rasmi, Yousef
name: Hosseinzadeh, Elyas
name: Rezaei, Sakineh
name: Balvardi, Mohadeseh
name: Kouchari, Mohammad Reza
name: Ebrahimi, Ghasem
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2021
Subjects: diabetes
comorbidity
inflammation
mortality
COVID-19

description: As a novel cause of pneumonia, coronavirus disease 2019 (COVID-19) has rapidly progressed worldwide. Previous studies have indicated COVID-19 patients with diabetes show higher mortality rates and more severe COVID-19 infection with an increased requirement for intensive care and hospital length of stay (LOS) compared to non-diabetic patients. The present study aimed to investigate the association of diabetes and COVID-19 outcome with severity of disease in hospitalized patients. The present case-control study included 268 patients diagnosed with COVID-19 who were hospitalized in Ayatollah Khoyi Hospital, Khoy, Iran. Diabetes was identified based on medical history and/or criteria of published documents. Out of 268 patients (median age of 59 years; 53.4 % male), 127 patients had diabetes (47 %). Diabetic patients had remarkably higher mortality rates (adjusted odds ratio, aOR: 3.36; confidence interval, CI: 1.17–9.66), requirement for invasive mechanical ventilation (IMV) (aOR: 4.59; CI: 1.38–15.25), and LOS (aOR: 1.13; CI: 1.06–1.24) compared to patients without diabetes. Inflammatory biomarkers including C-reactive protein (CRP), lactate dehydrogenase (LDH), and erythrocyte sedimentation rate (ESR) were increased in patients with diabetes compared to non-diabetic patients (P < 0.05 for all the comparisons). In hospitalized patients with COVID-19, diabetes was correlated with increased disease severity and mortality.
description: EXCLI Journal; 20:Doc444; ISSN 1611-2156
Subcortical Myoclonus and Associated Dystonia in 22q11.2 Deletion Syndrome
Creators: name: Van Iseghem, Vincent
name: McGovern, Eavan
name: Apartis, Emmanuelle
name: Keren, Boris
name: Vidailhet, Marie
name: Roze, Emmanuel
name: Degos, Bertrand
Publisher: name: Tremor and Other Hyperkinetic Movements
Year: 2020

description: Keywords: Myoclonus, dystonia, 22q11, 2 deletion syndrome Citation: Van Iseghem V, McGovern E, Apartis E, Keren B, Vidailhet M, Roze E, et al. Subcortical myoclonus and associated dystonia in 22q11.2 deletion syndrome. Tremor Other Hyperkinet Mov. 2020; 10. doi: 10.7916/tohm.v0.729
description: Tremor and Other Hyperkinetic Movements, Tremor and Other Hyperkinetic Movements
Effect of High-k Dielectric Layer on 1/f Noise Behavior in Graphene Field-Effect Transistors
Creators: name: Wang, Yifei
name: Ho, Vinh X.
name: Henschel, Zachary. N.
name: Cooney, Michael P.
name: Vinh, Nguyen Q.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We report the 1/f noise characteristics at low-frequency in graphene field-effect transistors that utilized a high-k dielectric tantalum oxide encapsulated layer (a few nanometers thick) placed by atomic layer deposition on Si3N4. A low-noise level of ~ 2.2 x 10^(-10) Hz-1 has been obtained at f = 10 Hz. The origin and physical mechanism of the noise can be interpreted by the McWhorter context, where fluctuations in the carrier number contribute dominantly to the low-frequency noise. Optimizing fabrication processes reduced the number of charged impurities in the graphene field-effect transistors. The study has provided insights into the underlying physical mechanisms of the noise at low-frequency for reducing the noise in graphene-based devices.
description: 15 pages, 4 figures, and SI
Pristidae
Creators: name: Golani, Daniel
name: Fricke, Ronald
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Pisces
Pristiformes
Pristidae

description: PRISTIDAE   Anoxypristis cuspidata (Latham 1794)
 Red Sea: (Garman 1913, as Pristus cuspidata; Compagno & Randall 1987).
 Gulf of Suez: ¯
 Gulf of Aqaba: ¯
 Red Sea main basin: -
 General distribution: Red Sea, Indo-West Pacific: East Africa east to Philippines and New Guinea.
 Pristis zijsron Bleeker 1851
 Gulf of Suez: Egypt (Rüppell 1837, as Pristis pectinatus).
 Gulf of Aqaba: ¯
 Red Sea main basin: Egypt (Klunzinger 1871, as Pristis pectinatus), Eritrea (Rüppell 1837, as Pristis pectinatus), Saudi Arabia (Rüppell 1837, as Pristis pectinatus).
 General distribution: Red Sea, Indo-West Pacific: East Africa east to Philippines and New Guinea.
description: Published as part of Golani, Daniel & Fricke, Ronald, 2018, Checklist of the Red Sea Fishes with delineation of the Gulf of Suez, Gulf of Aqaba, endemism and Lessepsian migrants, pp. 1-215 in Zootaxa 4509 (1) on pages 13-14, DOI: 10.11646/zootaxa.4509.1.1, http://zenodo.org/record/2607566
Real-time Pose and Shape Reconstruction of Two Interacting Hands With a Single Depth Camera
Creators: name: Mueller, Franziska
name: Davis, Micah
name: Bernard, Florian
name: Sotnychenko, Oleksandr
name: Verschoor, Mickeal
name: Otaduy, Miguel A.
name: Casas, Dan
name: Theobalt, Christian
Publisher: name: arXiv
Year: 2021
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: We present a novel method for real-time pose and shape reconstruction of two strongly interacting hands. Our approach is the first two-hand tracking solution that combines an extensive list of favorable properties, namely it is marker-less, uses a single consumer-level depth camera, runs in real time, handles inter- and intra-hand collisions, and automatically adjusts to the user's hand shape. In order to achieve this, we embed a recent parametric hand pose and shape model and a dense correspondence predictor based on a deep neural network into a suitable energy minimization framework. For training the correspondence prediction network, we synthesize a two-hand dataset based on physical simulations that includes both hand pose and shape annotations while at the same time avoiding inter-hand penetrations. To achieve real-time rates, we phrase the model fitting in terms of a nonlinear least-squares problem so that the energy can be optimized based on a highly efficient GPU-based Gauss-Newton optimizer. We show state-of-the-art results in scenes that exceed the complexity level demonstrated by previous work, including tight two-hand grasps, significant inter-hand occlusions, and gesture interaction.
description: ACM Transactions on Graphics (Proceedings SIGGRAPH 2019)
Tesla's fluidic diode and the electronic-hydraulic analogy
Creators: name: Nguyen, Quynh M.
name: Huang, Dean
name: Zauderer, Evan
name: Romanelli, Genevieve
name: Meyer, Charlotte L.
name: Ristroph, Leif
Publisher: name: arXiv
Year: 2021
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Physics Education (physics.ed-ph)
subject: FOS: Physical sciences

description: Reasoning by analogy is powerful in physics for students and researchers alike, a case in point being electronics and hydraulics as analogous studies of electric currents and fluid flows. Around 100 years ago, Nikola Tesla proposed a flow control device intended to operate similarly to an electronic diode, allowing fluid to pass easily in one direction but providing high resistance in reverse. Here we use experimental tests of Tesla's diode to illustrate principles of the electronic-hydraulic analogy. We design and construct a differential pressure chamber (akin to a battery) that is used to measure flow rate (current) and thus resistance of a given pipe or channel (circuit element). Our results prove the validity of Tesla's device, whose anisotropic resistance derives from its asymmetric internal geometry interacting with high-inertia flows, as quantified by the Reynolds number (here, Re ~ 1e3). Through the design and testing of new fluidic diodes, we explore the limitations of the analogy and the challenges of shape optimization in fluid mechanics. We also provide materials that may be incorporated into lesson plans for fluid dynamics courses, laboratory modules and further research projects.
description: 23 pages (double spaces), 8 figures
Additional file 4 of Enhancing existing medical school curricula with an innovative healthcare disparities curriculum
Creators: name: Treacy-Abarca, Sean
name: Aguilar, Marisela
name: Vassar, Stefanie D.
name: Hernandez, Estebes
name: El-Farra, Neveen S.
name: Brown, Arleen F.
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Additional file 4. Health Disparities Assessment.
A simple and efficient synthesis of imidazoquinoxalines and spiroquinoxalinones via pictect-spengler reaction using Wang resin
Creators: name: Gorle, Simhachalam
name: L, Vaikunta Rao
name: Y, Chiranjeevi
name: V, Dhanunjaya Rao A.
name: Mekala, Ramamohan
name: Tadiparthi, Krishnaji
name: Raghunadh, Akula
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: An efficient approach for the synthesis of various imidazoquinoxalines and spiroquinoxalinones has been reported from 2-(1H-imidazol-1-yl) aniline and different aldehydes using Wang-OSO3H as a reusable catalyst to get in good yields. The reaction condition has been optimized by screening in various solvents and a gram scale experiment has also demonstrated. Further, the substrate scope of the reaction has also been well demonstrated.
Isolated Voice Tremor: A Clinical Variant of Essential Tremor or a Distinct Clinical Phenotype?
Creators: name: Barkmeier-Kraemer, Julie M
Publisher: name: Tremor and Other Hyperkinetic Movements
Year: 2020

description: Background: The consensus statement by the Task Force on Tremor of the International Parkinson and Movement Disorder Society excludes individuals with “isolated voice tremor” as a clinical variant of essential tremor (ET). This clinical viewpoint presents a rationale for reconsideration of “isolated voice tremor” as a clinical variant of ET. Methods: Evidence from the literature was extracted to characterize the clinical phenotype of “isolated voice tremor,” or essential vocal tremor (EVT). Clinical features were extracted from relevant literature available at pubmed.gov using the terms “EVT,” “essential voice tremor,” “primary voice tremor,” and “organic voice tremor.” Results: The average age of onset in those with EVT was older than 60 years (range 19–84 years), with 75–93% being female. The typical duration of vocal tremor ranged from 1 to 13 years (average 6 years). The distribution of structures exhibiting tremor included the larynx, soft palate, pharynx, and base of tongue in the majority of patients, with some exhibiting tremor of the head and respiratory musculature. The condition of tremor occurred during speech and quiet respiration in 74% of individuals. Rate of tremor ranged from 4 to 10 Hz. Nearly 70% reported onset of vocal tremor prior to upper limb involvement. Family history of tremor was reported in 38–42% of individuals. Discussion: Those previously classified with EVT demonstrate a similar familial history, rate, tremor classification, and body distribution of ET. EVT is proposed as a clinical variant of ET in the pattern of onset and progression of body distribution from the midline cranial to spinal neural pathways. Keywords: Essential tremor, essential vocal tremor, essential voice tremor, primary vocal tremor, isolated voice tremor Citation: JM. Barkmeier-Kraemer. Isolated Voice Tremor: A Clinical Variant of Essential Tremor or a Distinct Clinical Phenotype? Tremor Other Hyperkinet Mov. 2020; 10. doi: 10.7916/tohm.v0.738
description: Tremor and Other Hyperkinetic Movements, Tremor and Other Hyperkinetic Movements
Floating Phase in 1D Transverse ANNNI Model
Creators: name: Chandra, Anjan Kumar
name: Dasgupta, Subinay
Publisher: name: arXiv
Year: 2006
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: To study the ground state of ANNNI chain under transverse field as a function of frustration parameter $κ$ and field strength $Γ$, we present here two different perturbative analyses. In one, we consider the (known) ground state at $κ=0.5$ and $Γ=0$ as the unperturbed state and treat an increase of the field from 0 to $Γ$ coupled with an increase of $κ$ from 0.5 to $0.5+rΓ$ as perturbation. The first order perturbation correction to eigenvalue can be calculated exactly and we could conclude that there are only two phase transition lines emanating from the point $κ=0.5$, $Γ=0$. In the second perturbation scheme, we consider the number of domains of length 1 as the perturbation and obtain the zero-th order eigenfunction for the perturbed ground state. From the longitudinal spin-spin correlation, we conclude that floating phase exists for small values of transverse field over the entire region intermediate between the ferromagnetic phase and antiphase.
description: 11 pages, 11 figures
Graphs, Quadratic Forms, and Quantum Codes
Creators: name: Grassl, Markus
name: Klappenecker, Andreas
name: Roetteler, Martin
Publisher: name: arXiv
Year: 2007
Subjects: subject: Quantum Physics (quant-ph)
subject: Information Theory (cs.IT)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: We show that any stabilizer code over a finite field is equivalent to a graphical quantum code. Furthermore we prove that a graphical quantum code over a finite field is a stabilizer code. The technique used in the proof establishes a new connection between quantum codes and quadratic forms. We provide some simple examples to illustrate our results.
description: 5 pages, 2 figures, paper presented at the 2002 IEEE International Symposium on Information Theory
Narcinidae Gill 1862
Creators: name: Golani, Daniel
name: Fricke, Ronald
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Elasmobranchii
Rajiformes
Narcinidae

description: NARCINIDAE   Heteronarce bentuviai (Baranes & Randall 1989)
 Gulf of Suez: ¯
 Gulf of Aqaba: Egypt (Baranes & Randall 1989, as Narcine bentuviai), Israel (Baranes & Randall 1989, as Narcine bentuviai), Jordan (Khalaf & Disi 1997).
 Red Sea main basin: ¯
 General distribution: Red Sea, northwestern Indian Ocean: Gulf of Aden.
description: Published as part of Golani, Daniel & Fricke, Ronald, 2018, Checklist of the Red Sea Fishes with delineation of the Gulf of Suez, Gulf of Aqaba, endemism and Lessepsian migrants, pp. 1-215 in Zootaxa 4509 (1) on page 14, DOI: 10.11646/zootaxa.4509.1.1, http://zenodo.org/record/2607566
Microscopic Patterns in the 2D Phase-Field-Crystal Model
Creators: name: Boissoniere, Gabriel Martine-La
name: Choksi, Rustum
name: Lessard, Jean-Philippe
Publisher: name: arXiv
Year: 2021
Subjects: subject: Numerical Analysis (math.NA)
subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics

description: Using the recently developed theory of rigorously validated numerics, we address the Phase-Field-Crystal (PFC) model at the microscopic (atomistic) level. We show the existence of critical points and local minimizers associated with "classical" candidates, grain boundaries, and localized patterns. We further address the dynamical relationships between the observed patterns for fixed parameters and across parameter space, then formulate several conjectures on the dynamical connections (or orbits) between steady states.
description: 34 pages, 7 figures. submitted
Amino acid ionic liquid-catalyzed synthesis, anti-Leishmania activity, molecular docking, molecular dynamic simulation, and ADME study of 3,4-dihydropyrimidin-2(1H)-(thio)ones
Creators: name: Rode, Nitin
name: Tantray, Aafaq
name: Shelar, Amruta
name: Patil, Rajendra
name: Terdale, Santosh
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: The synthesis of 3,4-dihydropyrimidin-2(1H)-(thio)one (DHPM) derivatives involving aromatic aldehyde, β-ketoesters and urea/thiourea using prolinium hydrogen sulfate (ProHSO4) as a catalyst has been studied. A variety of DHPM derivatives were obtained in high yield under solvent-free conditions in a short reaction time. The in-vitro screening of antileishmanial activity of both the oxo and the thioxo compounds showed significant activity against extracellular promastigotes. The aldehyde substituted at C-4 position with methyl (4g) in the oxo series and chloro (4m), methyl (4n) in the thioxo series imparted good bioactivity, with >80% reduction in viability at 50 µg/mL, with IC50 values 29.3, 29.3, and 28.3 µg/mL, respectively. Molecular docking study of the compound 4m displayed −6.4 kcal/mol binding energy. According to 50 ns molecular dynamics simulation study Leishmania major pteridine reductase 1 (PTR1) interacts well with the amino acid residues Phe-109, Leu-222, and Val-226. The in silico ADME study showed good drug-likeness properties.
Additional file 1 of The impact of implementing a person-centred pain management intervention on resistance to change and organizational culture
Creators: name: Angelini, Eva
name: Wolf, Axel
name: Wijk, Helle
name: Brisby, Helena
name: Baranto, Adad
Publisher: name: figshare
Year: 2021
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1.
Torpedinidae
Creators: name: Golani, Daniel
name: Fricke, Ronald
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Pisces
Torpediniformes
Torpedinidae

description: TORPEDINIDAE   Torpedo panthera Olfers 1831
 Gulf of Suez: Egypt (Rüppell 1837).
 Gulf of Aqaba: Israel (Klausewitz 1959a), Jordan (Khalaf & Disi 1997).
 Red Sea main basin: Egypt (Gohar & Mazhar 1964), Sudan (Bamber 1915), Saudi Arabia (Tortonese 1983), Yemen (Botros 1971).
 General distribution: Red Sea, northern Indian Ocean: Gulf of Aden east to Bay of Bengal (India).
 Torpedo sinuspersici Olfers 1831
 Gulf of Suez: Egypt (Gruvel & Chabanaud 1937).
 Gulf of Aqaba: Israel (Baranes & Golani 1993), Jordan (Khalaf 2004).
 Red Sea main basin: Egypt (Klunzinger 1871), Sudan (Bamber 1915).
 General distribution: Red Sea, western Indian Ocean: East Africa east to western India.
 * Torpedo suessii Steindachner 1898
 Gulf of Suez: ¯
 Gulf of Aqaba: ¯
 Red Sea main basin: Yemen (Steindachner 1898a).
 General distribution: Southern Red Sea endemic.
description: Published as part of Golani, Daniel & Fricke, Ronald, 2018, Checklist of the Red Sea Fishes with delineation of the Gulf of Suez, Gulf of Aqaba, endemism and Lessepsian migrants, pp. 1-215 in Zootaxa 4509 (1) on page 14, DOI: 10.11646/zootaxa.4509.1.1, http://zenodo.org/record/2607566
Complete classification of purely magnetic, non-rotating and non-accelerating perfect fluids
Creators: name: Wylleman, Lode
name: Bergh, Norbert Van den
Publisher: name: arXiv
Year: 2006
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Recently the class of purely magnetic non-rotating dust spacetimes has been shown to be empty (Wylleman, Class. Quant. Grav. 23, 2727). It turns out that purely magnetic rotating dust models are subject to severe integrability conditions as well. One of the consequences of the present paper is that also rotating dust cannot be purely magnetic when it is of Petrov type D or when it has a vanishing spatial gradient of the energy density. For purely magnetic and non-rotating perfect fluids on the other hand, which have been fully classified earlier for Petrov type D (Lozanovski, Class. Quant. Grav. 19, 6377), the fluid is shown to be non-accelerating if and only if the spatial density gradient vanishes. Under these conditions, a new and algebraically general solution is found, which is unique up to a constant rescaling, which is spatially homogeneous of Bianchi type $VI_0$, has degenerate shear and is of Petrov type I($M^\infty)$ in the extended Arianrhod-McIntosh classification. The metric and the equation of state are explicitly constructed and properties of the model are briefly discussed. We finally situate it within the class of normal geodesic flows with degenerate shear tensor.
description: 12 pages; introduction partly rewritten, notation made more clear, table of results added
Postural Directionality and Head Tremor in Cervical Dystonia
Creators: name: Chen, Qiyu
name: Vu, Jeanne P.
name: Cisneros, Elizabeth
name: Benadof, Casey N.
name: Zhang, Zheng
name: Barbano, Richard L.
name: Goetz, Christopher G.
name: Jankovic, Joseph
name: Jinnah, Hyder A.
name: Perlmutter, Joel S.
name: Appelbaum, Mark I.
name: Stebbins, Glenn T.
name: Comella, Cynthia L.
name: Peterson, David A.
Publisher: name: Tremor and Other Hyperkinetic Movements
Year: 2020

description: Background: Although abnormal head and neck postures are defining features of cervical dystonia (CD), head tremor (HT) is also common. However, little is known about the relationship between abnormal postures and HT in CD. Methods: We analyzed clinical data and video recordings from 185 patients enrolled by the Dystonia Coalition. We calculated the likelihood of their HT and HT type (“regular” vs. “jerky”) given directionality of abnormal head postures, disease duration, sex, and age. Results: Patients with retrocollis were more likely to have HT than patients with anterocollis (X2 (1, N = 121) = 7.98, p = 0.005). There was no difference in HT likelihood given left or right turning in laterocollis and rotation. Patients with HT had longer disease duration (t(183) = 2.27, p = 0.024). There was no difference in age between patients with and without HT. In a logistic regression model, anterocollis/retrocollis direction (X2 (1, N = 121) = 6.04, p = 0.014), disease duration (X2 (1, N = 121) = 7.28, p = 0.007), and the interaction term between age and disease duration (X2 (1, N = 121) = 7.77, p = 0.005) collectively contributed to HT likelihood. None of the postural directionality or demographic variables were associated with differential likelihood of having regular versus jerky HT. Discussion: We found that HT is more likely for CD patients with a specific directionality in their predominant posture. Our finding that CD patients with longer disease duration have a higher likelihood of HT also raises the question of whether HT becomes more likely over time in individual patients. Keywords: Cervical dystonia, head tremor, posture, disease duration, tremor type Citation: Chen Q, Vu JP, Cisneros E, Benadof CN, Zhang Z, Barbano RL, et al. Postural directionality and head tremor in cervical dystonia. Tremor Other Hyperkinet Mov. 2020: 10. doi: 10.7916/tohm.v0.745
description: Tremor and Other Hyperkinetic Movements, Tremor and Other Hyperkinetic Movements
Rate-dependent effects of lidocaine on cardiac dynamics: Development and analysis of a low-dimensional drug-channel interaction model
Creators: name: Docken, Steffen S.
name: Clancy, Colleen E.
name: Lewis, Timothy J.
Publisher: name: arXiv
Year: 2021
Subjects: subject: Quantitative Methods (q-bio.QM)
subject: FOS: Biological sciences

description: State-dependent Na+ channel blockers are often prescribed to treat cardiac arrhythmias, but many Na+ channel blockers are known to have pro-arrhythmic side effects. While the anti and proarrhythmic potential of a Na+ channel blocker is thought to depend on the characteristics of its rate-dependent block, the mechanisms linking these two attributes are unclear. Furthermore, how specific properties of rate-dependent block arise from the binding kinetics of a particular drug is poorly understood. Here, we examine the rate-dependent effects of the Na+ channel blocker lidocaine by constructing and analyzing a novel drug-channel interaction model. First, we identify the predominant mode of lidocaine binding in a 24 variable Markov model for lidocaine-Na+ channel interaction by Moreno et al. We then develop a novel 3-variable lidocaine-Na+ channel interaction model that incorporates only the predominant mode of drug binding. Our low-dimensional model replicates the extensive voltage-clamp data used to parameterize the Moreno et al. model. Furthermore, the effects of lidocaine on action potential upstroke velocity and conduction velocity in our model are similar to those predicted by the Moreno et al. model. By exploiting the low-dimensionality of our model, we derive an algebraic expression for level of rate-dependent block as a function of pacing frequency, restitution properties, diastolic and plateau potentials, and drug binding rate constants. Our model predicts that the level of rate-dependent block is sensitive to alterations in restitution properties and increases in diastolic potential, but it is insensitive to variations in the shape of the action potential waveform and lidocaine binding rates.
description: 38 pages, 6 figures
Enantioselective one-pot synthesis of 2-amino-4H-chromenes via C−H oxidation and Michael addition/ring closure sequences
Creators: name: Kim, Kyeong Seop
name: Kim, Dae Young
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine

description: The chiral 2-amino-4H-chromene derivatives were obtained from 2-alkyl-substituted phenol derivatives in moderate to high yields with excellent enantioselectivities through one-pot cascade via C–H oxidation/Michael addition/ring closure sequences using a binaphthyl-modified organocatalyst with low catalyst loading (1.25 mol%).
MICHAL GROVER-FRIEDLANDER, Vocal Apparitions: The Attraction of Cinema to Opera
Creators: name: Biancorosso, Giorgio
Publisher: name: Pavia University Press - Edizioni dell'Università degli Studi di Pavia
Year: 2008

description: Philomusica on-line, Vol 6, N° 1 (2007): Annata 2007
MARCUS CHR. LIPPE, Rossinis «opere serie». Zur musikalisch-dramatischen Konzeption
Creators: name: Carnini, Daniele
Publisher: name: Pavia University Press - Edizioni dell'Università degli Studi di Pavia
Year: 2008

description: Philomusica on-line, Vol 6, N° 1 (2007): Annata 2007
The validity of personality perceptions in discussion groups
Creators: name: Bruce, Melodie Nadine
Publisher: name: University of British Columbia
Year: 2010

description: The ability of group members to judge personality in long-term discussion groups was investigated. Participants were randomly assigned to groups of 5 to 7 members who met once a week for seven weeks. None of the participants in any group was previously acquainted. Prior to the first meeting, they completed a battery of self-report measures including the NEO Five Factor Inventory and the revised Interpersonal Adjective Scales. After the first, middle, and final meetings, group members rated each other on the Big Five personality traits and group participation. Self-reports showed moderate correlations (M=.31) with final-week single-item peer ratings. In addition, the correlations increased significantly over time. The same level of predictability was found when the criteria were peer free descriptions rather than ratings. Results are discussed in terms of the perception of personality in the context of group discussions.
Paroxysmal Kinesigenic Dyskinesia: First Molecularly Confirmed Case from Africa
Creators: name: Dekker, Marieke C.J.
name: Chengo, Rose
name: Kumburu, Happiness H.
name: Kamsteeg, Erik-Jan
name: Hamel, Ben C.
Publisher: name: Tremor and Other Hyperkinetic Movements
Year: 2020

description: Background: Paroxysmal kinesigenic dyskinesia (PKD) is a movement disorder, with an excellent response to carbamazepine treatment. It has been described in various populations, but not yet in an African population. Case report: In a patient who reported to clinic with side effects of carbamazepine, PRRT2 gene screening was performed based on a clinical history compatible with PKD. A common PRRT2 mutation was identified in this patient, hereby the first genetically confirmed PRRT2-associated PKD in Africa. Discussion: Reporting genetic confirmation of an unusual movement disorder from an equally unusual location shows the wide geographical distribution of PRRT2-associated disease. It also illustrates recognizability of this treatable disorder where the easiest accessible diagnostic tool is neurological history and examination. Keywords: Paroxysmal Kinesigenic Dyskinesia, Africa, PRRT2, carbamazepine Citation: Dekker MCJ, Chengo R, Kumburu HH, Kamsteeg E-J, Hamel BC. Paroxysmal kinesigenic dyskinesia: First molecularly confirmed case from Africa. Tremor Other Hyperkinet Mov. 2020; 10. doi: 10.7916/tohm.v0.742
description: Tremor and Other Hyperkinetic Movements, Tremor and Other Hyperkinetic Movements
Holmes Tremor due to Artery of Percheron Infarct: Clinical Case and Treatment Using Deep Brain Stimulation of the Vim and ZI Targets
Creators: name: O'Shea, Sarah A.
name: Elkind, Mitchell
name: Pullman, Seth L.
name: Ford, Blair
Publisher: name: Tremor and Other Hyperkinetic Movements
Year: 2020

description: Background: Holmes tremor (HT) arises from disruption of the cerebellothalamocortical pathways. A lesion can interrupt the projection at any point, resulting in this tremor. We describe a case of HT due to the rare artery of Percheron infarct and its successful treatment using deep brain stimulation. Case report: A 62-year-old woman with a right medial cerebral peduncle and bilateral thalamic stroke developed HT. Ventral intermediate nucleus (Vim) zona incerta (ZI) deep brain stimulation (DBS) surgery was performed, with improvement in her tremor. Discussion: Our case supports the theory that the more caudal ZI target in combination with Vim is beneficial in treating poorly DBS-responsive tremors such as HT. Keywords: Deep brain stimulation, Holmes tremor, tremor, neurostimulation Citation: O’Shea SA, Elkind M, Pullman SL, Ford B. Holmes tremor due to artery of percheron infarct: Clinical case and treatment using deep brain stimulation of the Vim and ZI targets. Tremor Other Hyperkinet Mov. 2020; 10. doi: 10.7916/tohm.v0.732
description: Tremor and Other Hyperkinetic Movements, Tremor and Other Hyperkinetic Movements
Strong Lagrangian solutions of the (relativistic) Vlasov-Poisson system for non-smooth, spherically symmetric data
Creators: name: Körner, Jacob
name: Rein, Gerhard
Publisher: name: arXiv
Year: 2021
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35Q70, 35Q83, 85A05

description: We prove a local existence and uniqueness result for the non-relativistic and relativistic Vlasov-Poisson system for data which need not even be continuous. The corresponding solutions preserve all the standard conserved quantities and are constant along their pointwise defined characteristic flow so that these solutions are suitable for the stability analysis of not necessarily smooth steady states. They satisfy the well-known continuation criterion and are global in the non-relativistic case. The only unwanted requirement on the data is that they be spherically symmetric.
description: 18 pages
Purposely Induced Tics: Electrophysiology
Creators: name: McGurrin, Patrick
name: Attaripour, Sanaz
name: Vial, Felipe
name: Hallett, Mark
Publisher: name: Tremor and Other Hyperkinetic Movements
Year: 2020

description: Keywords: Tics, Bereitschaftspotential, voluntary movement Citation: McGurrin P, Attaripour S, Vial F, Hallett M. Purposely induced tics: Electrophysiology. Tremor Other Hyperkinet Mov. 2020; 10. doi: 10.7916/tohm.v0.744
description: Tremor and Other Hyperkinetic Movements, Tremor and Other Hyperkinetic Movements
A New Type of Extremely Metal Poor Star
Creators: name: Cohen, Judith G.
name: McWilliam, Andrew
name: Christlieb, Norbert
name: Shectman, Stephen
name: Thompson, Ian
name: Melendez, Jorge
name: Wisotzki, Lutz
name: Reimers, Dieter
Publisher: name: arXiv
Year: 2007
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present an abundance analysis for the extremely metal poor star HE1424-0241 based on high dispersion spectra from HIRES at Keck. This star is a giant on the lower red giant branch with [Fe/H] ~ -4.0 dex. Relative to Fe, HE1424-0241 has normal Mg, but it shows a very large deficiency of Si, with epsilon(Si)/epsilon(Fe) ~ 1/10 and epsilon(Si)/epsilon(Mg) ~ 1/25 that of all previously known extremely metal poor giants or dwarfs. It also has a moderately large deficiency of Ca and a smaller deficit of Ti, combined with enhanced Mn and Co and normal or low C. We suggest that in HE1424-0241 we see the effect of a very small number of contributing supernovae, and that the SNII contributing to the chemical inventory of HE1424-0241 were biased in progenitor mass or in explosion characteristics so as to reproduce its abnormal extremely low Si/Mg ratio. HE1424-0241 shows a deficiency of the explosive alpha-burning elements Si, Ca and Ti coupled with a ratio [Mg/Fe] normal for EMP stars; Mg is produced via hydrostatic alpha-burning. The latest models of nucleosynthesis in SNII fail to reproduce the abundance ratios seen in HE1424-0241 for any combination of the parameter space of core-collapse explosions they explore.
description: Accepted to ApJL
Rhinobatidae
Creators: name: Golani, Daniel
name: Fricke, Ronald
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Pisces
Rajiformes
Rhinobatidae

description: RHINOBATIDAE   Glaucostegus halavi (Forsskål in Niebuhr 1775)
 Gulf of Suez: ¯
 Gulf of Aqaba: ¯
 Red Sea main basin: Egypt (Klunzinger 1871, as Rhinobatus halavi), Sudan (Bamber 1915, as Rhinobatus granulatus), Eritrea (Kossmann & Räuber 1877, as Rhinobatus halavi), Saudi Arabia (Forsskål in Niebuhr 1775, as Raja halavi; see Fricke 2008).
 General distribution: Red Sea, northwestern Indian Ocean: Persian Gulf and Gulf of Oman to Pakistan.
 Remark: A single specimen was recorded in Tunisia as a Lessepsian migrant into the eastern Mediterranean (Ben Souissi et al 2007).
 Glaucostegus thouin (Anonymous 1798)
 Gulf of Suez: Egypt (Duméril 1865, as Rhinobatus thouini).
 Gulf of Aqaba: ¯
 Red Sea main basin: Eritrea (Pellegrin 1912, as Rhinobatus thouini).
 General distribution: Red Sea, Indo-West Pacific: India east to Indonesia.
 Rhina ancylostoma Bloch & Schneider 1801
 Gulf of Suez: ¯
 Gulf of Aqaba: ¯
 Red Sea main basin: Egypt (Gohar & Mazhar 1964), Eritrea (Tortonese 1935), Saudi Arabia (Debelius 2007), (Spaet & Berumen 2015).
 General distribution: Red Sea, Indo-West Pacific: East Africa east to Philippines.
 Rhinobatos punctifer Compagno & Randall 1987
 Gulf of Suez: ¯
 Gulf of Aqaba: Egypt (Randall & Compagno 1995), Israel (Compagno & Randall 1987), Jordan (Khalaf & Disi 1997).
 Red Sea main basin: ¯
 General distribution: Red Sea, northwestern Indian Ocean: Gulf of Aden east to Pakistan.
 Rhynchobatus djiddensis (Forsskål in Niebuhr 1775)
 Gulf of Suez: Egypt (Forsskål in Niebuhr 1775, as Raja djiddensis; see Fricke 2008).
 Gulf of Aqaba: ¯
 Red Sea main basin: Egypt (Klunzinger 1871), Eritrea (Tortonese 1935, as Rhynchobatus djeddensis), Saudi Arabia (Forsskål in Niebuhr 1775, as Raja djiddensis; see Fricke 2008), Yemen (Forsskål in Niebuhr 1775, as Raja djiddensis; see Fricke 2008).
 General distribution: Red Sea, western Indian Ocean: East and South Africa to Madagascar, Réunion and Persian Gulf.
description: Published as part of Golani, Daniel & Fricke, Ronald, 2018, Checklist of the Red Sea Fishes with delineation of the Gulf of Suez, Gulf of Aqaba, endemism and Lessepsian migrants, pp. 1-215 in Zootaxa 4509 (1) on pages 14-15, DOI: 10.11646/zootaxa.4509.1.1, http://zenodo.org/record/2607566
Generalized Dystonia and Paroxysmal Dystonic Attacks due to a Novel ATP1A3 Variant
Creators: name: Zúñiga-Ramírez, Carlos
name: Kramis-Hollands, Mirelle
name: Mercado-Pimentel, Rodrigo
name: González-Usigli, Héctor Alberto
name: Sáenz-Farret, Michel
name: Soto-Escageda, Alberto
name: Fasano, Alfonso
Publisher: name: Tremor and Other Hyperkinetic Movements
Year: 2019

description: Background: Paroxysmal movement disorders are a heterogeneous group of neurological diseases, better understood in recent years thanks to widely available genetic testing. Case report: A pair of monozygotic twins with dystonia and paroxysmal attacks, resembling paroxysmal non-kinesigenic dyskinesias, due to a novel ATP1A3 variant are reported. The complete resolution of their paroxysms was achieved using levodopa and deep brain stimulation of the internal globus pallidus. Improvement of interictal dystonia was also achieved with this therapy. Discussion: Paroxysmal worsening of movement disorders should be suspected as part of the ATP1A3 spectrum. Treatment outcome might be predicted based on the phenotype. Keywords: ATP1A3, paroxysmal dyskinesia, dystonia, status dystonicus, AHC-2, rapid-onset parkinsonism-dystonia Citation: Zúñiga-Ramírez C, Kramis-Hollands M, Mercado-Pimentel R, González-Usigli HA, Sáenz-Farret M, Soto-Escageda A, et al. Slow orthostatic tremor: review of the current evidence. Tremor Other Hyperkinet Mov. 2019; 9. doi: 10.7916/tohm.v0.723
description: Tremor and Other Hyperkinetic Movements, Tremor and Other Hyperkinetic Movements
Injection into the Longus Colli Muscle via the Thyroid Gland
Creators: name: Tyślerowicz, Małgorzata
name: Jost, Wolfgang H.
Publisher: name: Tremor and Other Hyperkinetic Movements
Year: 2019

description: Background: Anterior forms of cervical dystonia are considered to be the most difficult to treat because of the deep cervical muscles that can be involved. Case Report: We report the case of a woman with cervical dystonia who presented with anterior sagittal shift, which required injections through the longus colli muscle to obtain a satisfactory outcome. The approach via the thyroid gland was chosen. Discussion: The longus colli muscle can be injected under electromyography (EMG), computed tomography (CT), ultrasonography (US), or endoscopy guidance. We recommend using both ultrasonography and electromyography guidance as excellent complementary techniques for injection at the C5-C6 level. Keywords: Anterior sagittal shift, longus colli, thyroid gland, sonography, electromyography Citation: Tyślerowicz M, Jost WH. Injection into the longus colli muscle via the thyroid gland. Tremor Other Hyperkinet Mov. 2019; 9. doi: 10.7916/tohm.v0.718
description: Tremor and Other Hyperkinetic Movements, Tremor and Other Hyperkinetic Movements
Microscopic Calculation of Fission Product Yields with Particle Number Projection
Creators: name: Verriere, Marc
name: Regnier, David
name: Schunck, Nicolas
Publisher: name: arXiv
Year: 2021
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Fission fragments' charge and mass distribution is an important input to applications ranging from basic science to energy production or nuclear non-proliferation. In simulations of nucleosynthesis or calculations of superheavy elements, these quantities must be computed from models, as they are needed in nuclei where no experimental information is available. Until now, standard techniques to estimate these distributions were not capable of accounting for fine-structure effects, such as the odd-even staggering of the charge distributions. In this work, we combine a fully-microscopic collective model of fission dynamics with a recent extension of the particle number projection formalism to provide the highest-fidelity prediction of the primary fission fragment distributions for the neutron-induced fission of $^{235}$U and $^{239}$Pu. We show that particle number projection is an essential ingredient to reproduce odd-even staggering in the charge yields and benchmark the performance of various empirical probability laws that could simulate its effect. This new approach also enables for the first time the realistic determination of two-dimensional isotopic yields within nuclear density functional theory.
description: 15 pages, 11 figures
Re-examining the Philosophical Underpinnings of the Melting Pot vs. Multiculturalism in the Current Immigration Debate in the United States
Creators: name: Woldeab, Daniel
name: Yawson, Robert
name: Woldeab, Irina
Publisher: name: arXiv
Year: 2021
Subjects: subject: General Economics (econ.GN)
subject: FOS: Economics and business

description: Immigration to the United States is certainly not a new phenomenon, and it is therefore natural for immigration, culture and identity to be given due attention by the public and policy makers. However, current discussion of immigration, legal and illegal, and the philosophical underpinnings is lost in translation, not necessarily on ideological lines, but on political orientation. In this paper we reexamine the philosophical underpinnings of the melting pot versus multiculturalism as antecedents and precedents of current immigration debate and how the core issues are lost in translation. We take a brief look at immigrants and the economy to situate the current immigration debate. We then discuss the two philosophical approaches to immigration and how the understanding of the philosophical foundations can help streamline the current immigration debate.
The synthesis of phenyl carbamates catalyzed by iron (II) bromide: An oxidative approach for cross-coupling of phenols with formamides
Creators: name: Vala, Manoj Kumar
name: Sudhakar, Chithaluri
name: Adurthi, Suryakumari
name: Vanam, Shekhar
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Inorganic Chemistry
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: The carbamate group is a key structural motif in many approved drugs and pro-drugs. There is increasing use of carbamates in the medicinal chemistry and agrochemical industry. We present, reagents and chemical methodologies for the synthesis of carbamates, and recent applications. The direct coupling of simple phenols with mono- and di-alkyl formamides provided the phenylcarbamate products.
Cervical Dystonia Mimics: A Case Series and Review of the Literature
Creators: name: Raju, Srinivas
name: Ravi, Amogh
name: Prashanth, LK
Publisher: name: Tremor and Other Hyperkinetic Movements
Year: 2019

description: Background: Cervical dystonia is mostly idiopathic in nature. However, a small subset of cases are mimics, leading to diagnostic pitfalls. There is paucity of literature on pseudodystonias affecting the cervical region. Method: We performed a retrospective review of patients attending a movement disorders clinic over a period of 7 years (2012–2018). Among them, those who were considered to have mimics of cervical dystonia based upon clinical and supportive investigations were included. Results: Six out of 2,412 patients (0.24%) were diagnosed as cervical dystonia mimics and the causes included isolated neck extensor myopathy (2), craniovertebral junction anomalies (2), sternocleidomastoid fibrosis (1) and post traumatic sequelae (1). Among these patients, three patients had received various treatments for cervical dystonia, including botulinum toxin injections. Discussion: Mimics of isolated cervical dystonia are rare. A high degree of suspicion and proper diligent clinical assessment assists management and prognostication. Keywords: Cervical dystonia, pseudodystonia, dystonia mimics, head drop, neck extensor myopathy Citation: Raju S, Ravi A, Prashanth LK. Cervical dystonia mimics: A case series and review of the literature. Tremor Other Hyperkinet Mov. 2019; 9. doi: 10.7916/tohm.v0.707
description: Tremor and Other Hyperkinetic Movements, Tremor and Other Hyperkinetic Movements
Green synthesis and antimicrobial activity of substituted diethyl (((5-(ethylthio)-1,3,4-thiadiazol-2-yl)amino)(phenyl)methyl)phosphonates
Creators: name: Sarva, Santhisudha
name: Dunnutala, Renuka
name: Tellamekala, Sreekanth
name: Gundluru, Mohan
name: Cirandur, Suresh Reddy
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 60506 Virology

description: The one-pot, three-component, and facile synthesis of substituted diethyl (((5-(ethylthio)-1,3,4-thiadiazol-2-yl)amino)(phenyl)methyl)phosphonates (4a–j) has been achieved from the reaction of 2-amino-5-ethylthio-1,3,4-thiadiazole (1), various aromatic aldehydes (2a–j) and diethylphosphite (3) using Kabachnik–Fields reaction in the presence SnO2 nanoparticles as an efficient heterogeneous catalyst under solvent-free MWI condition. Furthermore, these series of new compounds were characterized by melting point, IR, NMR, and mass spectra. The newly synthesized compounds were evaluated for their antimicrobial activity which showed good activity compared to standard.
Clinical Profile of Non-Motor Symptoms in Patients with Essential Tremor: Impact on Quality of Life and Age-Related Differences
Creators: name: Shalash, Ali S.
name: Mohamed, Hadeer
name: Mansour, Alia H.
name: Elkady, Ahmed
name: Elrassas, Hanan
name: Hamid, Eman
name: Elbalkimy, Mahmoud H.
Publisher: name: Tremor and Other Hyperkinetic Movements
Year: 2019

description: Background: Identifying the clinical phenotypes of non-motor symptoms (NMSs) of essential tremor (ET) among different populations is necessary due to their impact on the quality of life (QoL). This study aimed to investigate the clinical phenotype and impact of NMSs on QoL in Egyptian patients with ET. Methods: Thirty ET patients were compared to 30 matched controls. Subjects were evaluated by the Fahn-Tolosa-Marin Tremor Rating Scale, Non-Motor Symptoms Scale (NMSS), Montreal Cognitive Assessment, Hamilton Anxiety Rating Scale, Beck Depression Inventory, Pittsburgh Sleep quality Index, and the Short Form 36 Health Survey Questionnaire. Both groups were divided into two subgroups of younger (<45 years, 14 patients) and older age (>45 years, 16 patients) groups, to investigate age-related differences. Results: ET patients showed significantly worse cognition, depression, anxiety, sleep and NMSS domains (p
description: Tremor and Other Hyperkinetic Movements, Tremor and Other Hyperkinetic Movements