cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Isoforms of MUC16 activate oncogenic signaling through EGF receptors to enhance the progression of pancreatic cancer
Creators: name: Yu, Fang
name: Qiu, Fang
name: Maurer, Hans Carlo
name: Peng, Xianlu Laura
name: Radhakrishnan, Prakash
name: Madiyalakan, Ragupathy
name: Clausen, Henrik
name: Hollingsworth, Michael A
name: Caffrey, Thomas
name: Thomas, Divya
name: Marcos-Silva, Lara
name: Grandgenett, Paul M
name: Grunkemeyer, James A
name: Olive, Kenneth P
name: Lee, Hye-Rim
name: Liu, Xiang
name: Sagar, Satish
name: O'Connell, Kelly A
name: Swanson, Benjamin
name: Wandall, Hans H
name: Steentoft, Catharina
name: Yeh, Jen Jen
name: Mandel, Ulla
Publisher: name: Elsevier
Year: 2020

description: Aberrant expression of CA125/MUC16 is associated with pancreatic ductal adenocarcinoma (PDAC) progression and metastasis. However, knowledge of the contribution of MUC16 to pancreatic tumorigenesis is limited. Here, we show that MUC16 expression is associated with disease progression, basal-like and squamous tumor subtypes, increased tumor metastasis, and short-term survival of PDAC patients. MUC16 enhanced tumor malignancy through the activation of AKT and GSK3β oncogenic signaling pathways. Activation of these oncogenic signaling pathways resulted in part from increased interactions between MUC16 and epidermal growth factor (EGF)-type receptors, which were enhanced for aberrant glycoforms of MUC16. Treatment of PDAC cells with monoclonal antibody (mAb) AR9.6 significantly reduced MUC16-induced oncogenic signaling. mAb AR9.6 binds to a unique conformational epitope on MUC16, which is influenced by O-glycosylation. Additionally, treatment of PDAC tumor-bearing mice with either mAb AR9.6 alone or in combination with gemcitabine significantly reduced tumor growth and metastasis. We conclude that the aberrant expression of MUC16 enhances PDAC progression to an aggressive phenotype by modulating oncogenic signaling through ErbB receptors. Anti-MUC16 mAb AR9.6 blocks oncogenic activities and tumor growth and could be a novel immunotherapeutic agent against MUC16-mediated PDAC tumor malignancy.
Association between longer hospitalization and development of de novo donor specific antibodies in simultaneous liver–kidney transplant recipients
Creators: name: Yazawa, Masahiko
name: Cseprekal, Orsolya
name: Helmick, Ryan A.
name: Talwar, Manish
name: Balaraman, Vasanthi
name: Podila, Pradeep S. B.
name: Fossey, Sallyanne
name: Satapathy, Sanjaya K.
name: Eason, James D.
name: Molnar, Miklos Z.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Science Policy
subject: Computational Biology

description: De novo Donor Specific Antibodies (DSA) are considered as a risk factor for the kidney allograft outcomes in recipients after simultaneous liver–kidney transplantation (SLKT). We hypothesized that length of hospital stay (LOS) might be associated with de novo DSA development of due to the increased likelihood of receiving blood transfusions with reduced immunosuppressive regimens. This study is a single-center, retrospective cohort study consisting of 85 recipients who underwent SLKT from 2009 to 2018 in our hospital. We divided the patients into two groups according to LOS [long hospital stay (L) group (LOS >14 days) and short hospital stay (S) group (LOS ≤14 days)]. Propensity score (PS) has been created using logistic regression to predict LOS greater than median of 14 days. The association between the presence of de novo DSA and LOS was assessed by logistic regression models adjusted for PS. The mean age at transplantation of the entire cohort was 55.5 ± 10.1 years. Sixty percent of the recipients were male and Caucasian. Median LOS in (L) group was three-fold longer than (S) group [L: median 30 days (IQR: 21–52), S: median 8.5 days (IQR: 7–11)]. Eight patients developed de novo DSA after SLKT (9.4%), all of them were in (L) group. Longer LOS was significantly associated with higher risk of development of de novo DSA in unadjusted (OR+ each 5 days: 1.09, 95% CI:1.02–1.16) and PS adjusted (OR+ each 5 days: 1.11, 95% CI:1.02–1.21) analysis. Longer hospitalization is significantly associated with the development of de novo DSA in SLKT.
Supplemental Material - Identification of ferroptosis-related molecular markers in glomeruli and tubulointerstitium of lupus nephritis
Creators: name: Wang, Wenqian
name: Lin, Zeying
name: Feng, Jieye
name: Liang, Qixuan
name: Zhao, Jinjin
name: Zhang, Gengbiao
name: Chen, Ruilin
name: Fu, Rong
Publisher: name: SAGE Journals
Year: 2022
Subjects: Aged Health Care

description: Supplemental Material for Identification of ferroptosis-related molecular markers in glomeruli and tubulointerstitium of lupus nephritis by Wenqian Wang, Zeying Lin, Jieye Feng, Qixuan Liang, Jinjin Zhao, GengbiaoZhang, Ruilin Chen, and Rong Fu in Lupus.
Chalcone Derivatives: Promising Starting Points for Drug Design
Creators: name: Peixoto, Josana C.
name: Rosseto, Lucimar P.
name: Muratov, Eugene N.
name: Cravo, Pedro V. L.
name: Pereira, Maristela
name: Andrade, Carolina H.
name: Gomes, Marcelo N.
name: Neves, Bruno J.
Publisher: name: MDPI
Year: 2017

description: Medicinal chemists continue to be fascinated by chalcone derivatives because of their simple chemistry, ease of hydrogen atom manipulation, straightforward synthesis, and a variety of promising biological activities. However, chalcones have still not garnered deserved attention, especially considering their high potential as chemical sources for designing and developing new effective drugs. In this review, we summarize current methodological developments towards the design and synthesis of new chalcone derivatives and state-of-the-art medicinal chemistry strategies (bioisosterism, molecular hybridization, and pro-drug design). We also highlight the applicability of computer-assisted drug design approaches to chalcones and address how this may contribute to optimizing research outputs and lead to more successful and cost-effective drug discovery endeavors. Lastly, we present successful examples of the use of chalcones and suggest possible solutions to existing limitations.
Computational drug discovery for the Zika virus
Creators: name: Melo-Filho, Cleber Camilo
name: Mottin, Melina
name: Ekins, Sean
name: Torres, Pedro Henrique Monteiro
name: Muratov, Eugene
name: Borba, Joyce Villa Verde Bastos
name: Braga, Rodolpho Campos
name: Andrade, Carolina Horta
name: Perryman, Alexander
name: Neves, Bruno Junior
Publisher: name: FapUNIFESP (SciELO)
Year: 2018

description: Few Zika virus (ZIKV) outbreaks had been reported since its first detection in 1947, until the recent epidemics occurred in South America (2014/2015) and expeditiously became a global public health emergency. This arbovirus reached 0.5-1.3 million cases of ZIKV infection in Brazil in 2015 and rapidly spread in new geographic areas such as the Americas. Despite the mild symptoms of the Zika fever, the major concern is related to the related severe neurological disorders, especially microcephaly in newborns. Advances in ZIKV drug discovery have been made recently and constitute promising approaches to ZIKV treatment. In this review, we summarize current computational drug discovery efforts and their applicability to discovery of anti-ZIKV drugs. Lastly, we present successful examples of the use of computational approaches to ZIKV drug discovery.
Association of trimethylamine N-Oxide with cardiovascular and all-cause mortality in hemodialysis patients
Creators: name: Zhang, Pan
name: Zou, Jian-Zhou
name: Chen, Jun
name: Tan, Xiao
name: Xiang, Fang-Fang
name: Shen, Bo
name: Hu, Jia-Chang
name: Wang, Jia-Lin
name: Wang, Ya-Qiong
name: Yu, Jin-Bo
name: Nie, Yu-Xin
name: Chen, Xiao-Hong
name: Yu, Jia-Wei
name: Zhang, Zhen
name: Lv, Wen-Lv
name: Xie, Ye-Qing
name: Cao, Xue-Sen
name: Ding, Xiao-Qiang
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Trimethylamine-N-Oxide (TMAO) is a proatherogenic and prothrombotic metabolite. Our study examined the association of plasma TMAO level with cardiovascular and all-cause mortality in hemodialysis (HD) patients. Patients who were at least 18 years-old and received HD for at least 6 months were enrolled within 6 months. Patients with coronary heart disease, congestive heart failure, arrhythmia, or stroke within 3 months before study onset were excluded. The primary endpoints were cardiovascular and all-cause death, and the secondary endpoint was cerebrovascular death. We recruited 252 patients and divided them into a high-TMAO group (>4.73 μg/mL) and a low-TMAO group (≤4.73 μg/mL). The median follow-up time was 73.4 months (interquartile range: 42.9, 108). A total of 123 patients died, 39 from cardiovascular disease, 19 from cerebrovascular disease, and 65 from other causes. Kaplan-Meier analysis indicated that the high-TMAO group had a greater incidence of cardiovascular death (Log-Rank: p = 0.006) and all-cause death (Log-Rank: p < 0.001). Cox regression analysis showed that high TMAO level was significantly associated with cardiovascular and all-cause mortality. After adjustment for confounding, this association remained significant for cardiovascular mortality (TMAO as a continuous variable: HR: 1.18, 95%CI: 1.07, 1.294, p < 0.001; TMAO as a dichotomous variable: HR: 3.44, 95%CI: 1.68, 7.08, p < 0.001) and all-cause mortality (TMAO as a continuous variable: HR: 1.14, 95%CI: 1.08, 1.21, p < 0.001; TMAO as a dichotomous variable: HR: 2.54, 95%CI: 1.71, 3.76, p < 0.001). High plasma TMAO level is significantly and independently associated with cardiovascular and all-cause mortality in HD patients.
Multi-Atlas Segmentation of Anatomical Brain Structures Using Hierarchical Hypergraph Learning
Creators: name: Gao, Yue
name: Wu, Guorong
name: Liang, Peipeng
name: Shi, Yonghong
name: Dong, Pei
name: Guo, Yanrong
Publisher: name: Institute of Electrical and Electronics Engineers (IEEE)
Year: 2019

description: Accurate segmentation of anatomical brain structures is crucial for many neuroimaging applications, e.g., early brain development studies and the study of imaging biomarkers of neurodegenerative diseases. Although multi-atlas segmentation (MAS) has achieved many successes in the medical imaging area, this approach encounters limitations in segmenting anatomical structures associated with poor image contrast. To address this issue, we propose a new MAS method that uses a hypergraph learning framework to model the complex subject-within and subject-to-atlas image voxel relationships and propagate the label on the atlas image to the target subject image. To alleviate the low-image contrast issue, we propose two strategies equipped with our hypergraph learning framework. First, we use a hierarchical strategy that exploits high-level context features for hypergraph construction. Because the context features are computed on the tentatively estimated probability maps, we can ultimately turn the hypergraph learning into a hierarchical model. Second, instead of only propagating the labels from the atlas images to the target subject image, we use a dynamic label propagation strategy that can gradually use increasing reliably identified labels from the subject image to aid in predicting the labels on the difficult-to-label subject image voxels. Compared with the state-of-the-art label fusion methods, our results show that the hierarchical hypergraph learning framework can substantially improve the robustness and accuracy in the segmentation of anatomical brain structures with low image contrast from magnetic resonance (MR) images.
L’ENTREPRENEURIAT FEMININ EN TUNISIE : INDICATEURS ET DETERMINANTS DE SUCCES
Creators: name: HASSINE, Amine Ben Hadj
Publisher: name: Revue Economie, Gestion et Société
Year: 2016
Subjects: Women entrepreneurship, socio-cultural factors, economic factors, support structures, Tunisia.

description: Sujets de débats micro et macro-économiques, institutionnels ou encore politiques, discipline scientifique, module d’enseignement ou thème de recherche tant aspiré par des experts, des hommes de terrain ou des académiciens, l’entrepreneuriat suscite sans cesse la convoitise à tous les niveaux et à des différents degrés d’intérêts du moment où il est toujours perçu comme générateur de solutions alternatives aux innombrables problèmes d’ordre économique, social ou autre. Cependant chaque fois que le concept en question est manipulé dans le cadre d’une approche féministe, il laisse filer de multiples controverses. D’ailleurs, il est même consensuellement qualifié de phénomène. Le but de cet article est d'analyser les configurations significatives de l'esprit d'entreprendre féminin. À cet égard, nous nous concentrons essentiellement sur les principaux facteurs influant l'entreprenariat féminin en particulier socioculturels, économiques et politiques qui, d’après nos résultats, se sont révélés comme étant les plus importants déterminants de la réussite de l'entrepreneuriat féminin. En outre, nos résultats suggèrent que le succès de l'entrepreneuriat féminin peut être expliqué également par le système de support ou d’appui ainsi que par les politiques gouvernementales.
description: Revue Economie, Gestion et Société, No 7 (2016)
Additional file 1 of Co-design of a question prompt list about pregnancy and childbearing for women with polycystic kidney disease: an exploratory sequential mixed-methods study
Creators: name: Holton, Sara
name: Nelson, Craig
name: Rasmussen, Bodil
name: Levidiotis, Vicki
Publisher: name: figshare
Year: 2023
Subjects: subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 1: Supplementary table 1. Discussion group themes and participant quotes
Arterial stiffness and dementia pathology
Creators: name: Wagenknecht, Lynne E
name: Gottesman, Rebecca F
name: Craft, Suzanne
name: Mintz, Akiva
name: Zhou, Yun
name: Wong, Dean
name: Palta, Priya
name: Knopman, David
name: Heiss, Gerardo
name: Mosley, Thomas H
name: Hughes, Timothy M
Publisher: name: Wolters Kluwer
Year: 2018

description: OBJECTIVE: Arterial stiffness has been associated with evidence of cerebral small vessel disease (cSVD) and fibrillar β-amyloid (Aβ) deposition in the brain. These complex relationships have not been examined in racially and cognitively diverse cohorts. METHODS: The Atherosclerosis Risk in Communities (ARIC)-Neurocognitive Study collected detailed cognitive testing for adjudication of dementia and mild cognitive impairment (MCI), brain MRI, and arterial stiffness by pulse wave velocity (PWV, carotid-femoral [cfPWV] and heart-carotid [hcPWV]). The ARIC-PET ancillary study added Aβ imaging using florbetapir ([18F]-AV-45) to obtain standardized uptake volume ratios and defined global Aβ-positivity as standardized uptake volume ratio >1.2. One-SD increase in PWV was related to brain volume, MRI-defined cSVD (e.g., cerebral microbleeds and white matter hyperintensity), and cortical Aβ deposition adjusted for age, body mass index, sex, race, and APOE ε4 status. We examined the cross-sectional relationships including interactions by race, APOE ε4 status, and cognition. RESULTS: Among the 320 ARIC-PET participants (76 [5] years, 45% black, 27% MCI), greater central stiffness (hcPWV) was associated with greater Aβ deposition (odds ratio [OR] = 1.31, 95% confidence interval [CI] 1.01-1.71). Greater central stiffness (cfPWV) was significantly associated with having lower brain volumes in Alzheimer disease-susceptible regions (in mm3, β = -1.5 [0.7 SD], p = 0.03) and high white matter hyperintensity burden (OR = 1.6, 95% CI 1.2-2.1). Furthermore, cfPWV was associated with a higher odds of concomitant high white matter hyperintensity and Aβ-positive scans (OR = 1.4, 95% CI 1.1-2.1). These associations were strongest among individuals with MCI and did not differ by race or APOE ε4 status. CONCLUSIONS: Arterial stiffness, measured by PWV, is an emerging risk factor for dementia through its repeated relationships with cognition, cSVD, and Aβ deposition.
Supplemental Material - Early follow-up quality of life and mental health of patients with congenital vascular malformations cared for in a multi-disciplinary specialist centre
Creators: name: Pang, Calver
name: Nisbet, Rebecca
name: Gibson, Michael
name: Evans, Nicholas
name: Khalifa, Mohamed
name: Papadopoulou, Anthie
name: Tsui, Janice
name: Hamilton, George
name: Brookes, Jocelyn
name: Lim, Chung Sim
Publisher: name: SAGE Journals
Year: 2022
Subjects: Cardiology

description: Supplemental Material for Early follow-up quality of life and mental health of patients with congenital vascular malformations cared for in a multi-disciplinary specialist center by Calver Pang, Rebecca Nisbet, Michael Gibson, Nicholas Evans, Mohamed Khalifa, Anthie Papadopoulou, Janice Tsui, George Hamilton, Jocelyn Brookes, Chung Sim Lim in Phlebology
Exploring the pathophysiology of emotion-based impulsivity: The roles of the sympathetic nervous system and hostile reactivity
Creators: name: Eisenlohr-Moul, Tory A.
name: Walsh, Erin C.
name: Peters, Jessica R.
name: Derefinko, Karen J.
Publisher: name: Elsevier
Year: 2018

description: The tendency to engage in impulsive behavior in the context of negative affect, known as negative urgency, has emerged as a powerful transdiagnostic predictor of behavioral dysregulation. Although general vulnerability to negative affect (neuroticism) correlates with negative urgency, not all neurotic individuals engage in urgent behavior. Given prior experimental evidence that sympathetic nervous system (SNS) activation may promote emotion-related impulsivity, the present study examines tonic SNS activity as a moderator of the link between neuroticism and negative urgency. Participants (N-=-194) completed measures of neuroticism and negative urgency, as well as a stress task. They also underwent assessment of tonic SNS activity (cardiac pre-ejection period). The link between neuroticism and negative urgency was strengthened for individuals with higher tonic SNS activity; however, this was not the case for behavioral performance on the task. A similar pattern was demonstrated for hostile reactivity to the stress task; increased hostile response partially explained the interaction between SNS activation and neuroticism on negative urgency. These findings suggest a potential facilitative role of the SNS in hostile reactivity and emotion-driven impulsivity among more neurotic individuals.
Perimenstrual exacerbation of symptoms in borderline personality disorder: evidence from multilevel models and the Carolina Premenstrual Assessment Scoring System
Creators: name: Girdler, Susan S.
name: Owens, Sarah A.
name: Dawson, Danyelle N.
name: Schmalenberger, Katja M.
name: Peters, Jessica R.
name: Eisenlohr-Moul, Tory A.
Publisher: name: Cambridge University Press (CUP)
Year: 2018

description: BACKGROUND: Individuals with a borderline personality disorder (BPD) suffer from a constellation of rapidly shifting emotional, interpersonal, and behavioral symptoms. The menstrual cycle may contribute to symptom instability among females with this disorder. METHODS: Fifteen healthy, unmedicated females with BPD and without dysmenorrhea reported daily symptoms across 35 days. Urine luteinizing hormone and salivary progesterone (P4) were used to confirm ovulation and cycle phase. Cyclical worsening of symptoms was evaluated using (1) phase contrasts in multilevel models and (2) the Carolina Premenstrual Assessment Scoring System (C-PASS), a protocol for evaluating clinically significant cycle effects on symptoms. RESULTS: Most symptoms demonstrated midluteal worsening, a perimenstrual peak, and resolution of symptoms in the follicular or ovulatory phase. Post-hoc correlations with person-centered progesterone revealed negative correlations with most symptoms. Depressive symptoms showed an unexpected delayed pattern in which baseline levels of symptoms were observed in the ovulatory and midluteal phases, and exacerbations were observed during both the perimenstrual and follicular phases. The majority of participants met C-PASS criteria for clinically significant (>=30%) symptom exacerbation. All participants met the emotional instability criterion of BPD, and no participant met DSM-5 criteria for premenstrual dysphoric disorder (PMDD). CONCLUSIONS: Females with BPD may be at elevated risk for perimenstrual worsening of emotional symptoms. Longitudinal studies with fine-grained hormonal measurement as well as hormonal experiments are needed to determine the pathophysiology of perimenstrual exacerbation in BPD.
Helicobacter pylori infection is associated with elevated galactose-deficient IgA1 in IgA nephropathy
Creators: name: Liu, Xing-Zi
name: Zhang, Yue-Miao
name: Jia, Ni-Ya
name: Zhang, Hong
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Mucosal immunity plays an important role in the pathogenesis of IgA nephropathy (IgAN). This study aimed to investigate if infection of Helicobacter pylori (H. pylori), a common bacteria in the gastrointestinal tract, associated with IgAN. This study included 261 patients with IgAN and 46 healthy controls. Clinical information and plasma samples were collected from patients and healthy controls. H. pylori infection was confirmed by western blot. Plasma IgA1 and galactose-deficient IgA1 (Gd-IgA1) levels were detected by specific enzyme-linked immunosorbent assay. Total H. pylori infection rates showed no statistical differences between IgAN patients and healthy controls, but the infection rates of type I H. pylori in IgAN patients were significantly higher than those in healthy controls (44.4 vs. 28.3%, p = 0.040). Compared with uninfected patients, the systolic blood pressure, 24-h proteinuria, and blood urea nitrogen levels were significantly higher in patients with H. pylori infection (126.0 ± 15.5 vs. 119.6 ± 14.5 mmHg, p = 0.010; 1.8 ± 2.7 vs. 1.2 ± 1.4 g/24h, p = 0.013; 7.9 ± 5.4 vs. 6.7 ± 3.9 μmol/L, p = 0.042), especially in patients with type I infection (126.5 ± 15.4 vs. 119.6 ± 14.5 mmHg, p = 0.002; 1.9 ± 2.9 vs. 1.2 ± 1.4 g/24 h, p = 0.033; 8.1 ± 5.6 vs. 6.7 ± 3.9 μmol/L, p = 0.041). Similarly, patients with IgAN and type I H. pylori infection showed higher plasma Gd-IgA1 levels than uninfected patients (5.5 ± 2.2 vs. 4.5 ± 2.2 μg/mL, p = 0.037). Virulent type I H. pylori infection is more common in patients with IgAN. Patients with IgAN and type I H. pylori infection showed lower renal function and higher underglycosylation of plasma IgA1.
Pretreatment brain connectivity during positive emotion upregulation predicts decreased anhedonia following behavioral activation therapy for depression
Creators: name: Smoski, Moria J.
name: Minkel, Jared
name: Bizzell, Joshua
name: Dichter, Gabriel S.
name: Walsh, Erin C.
name: Eisenlohr-Moul, Tory A.
name: Petty, Chris
name: Carl, Hannah
name: Crowther, Andrew
Publisher: name: Elsevier
Year: 2018

description: BACKGROUND: Neurobiological predictors of antidepressant response may help guide treatment selection and improve response rates to available treatments for major depressive disorder (MDD). Behavioral activation therapy for depression (BATD) is an evidence-based intervention designed to ameliorate core symptoms of MDD by promoting sustained engagement with value-guided, positively-reinforcing activities. The present study examined pre-treatment task-based functional brain connectivity as a predictor of antidepressant response to BATD. METHODS: Thirty-three outpatients with MDD and 20 nondepressed controls completed a positive emotion regulation task during fMRI after which participants with MDD received up to 15 sessions of BATD. We used generalized psychophysiological interaction analyses to examine group differences in pre-treatment functional brain connectivity during intentional upregulation of positive emotion to positive images. Hierarchical linear models were used to examine whether group differences in functional connectivity predicted changes in depression and anhedonia over the course of BATD. RESULTS: Compared to controls, participants with MDD exhibited decreased connectivity between the left middle frontal gyrus and right temporoparietal regions during upregulation of positive emotion. Within the MDD group, decreased connectivity of these regions predicted greater declines in anhedonia symptoms over treatment. LIMITATIONS: Future studies should include comparison treatments and longitudinal follow-up to clarify the unique effects of BATD on neural function and antidepressant response. CONCLUSIONS: Results are consistent with previous work showing BATD may be particularly effective for individuals with greater disturbances in brain reward network function, but extend these findings to highlight the importance of frontotemporoparietal connectivity in targeting symptoms of low motivation and engagement.
sj-docx-1-han-10.1177_15589447221141485 – Supplemental material for Type of Work and Preoperative Ability to Perform Work Affect Return to Usual Work Following Proximal Interphalangeal Joint Arthroplasty for Osteoarthritis
Creators: name: Notermans, Bo J. W.
name: Teunissen, Joris S.
name: Selles, Ruud W.
name: de Boer, Luitzen H. L.
name: van der Heijden, Brigitte E. P. A.
Publisher: name: SAGE Journals
Year: 2022
Subjects: subject: Medicine
subject: 110314 Orthopaedics
subject: FOS: Clinical medicine
subject: 110604 Sports Medicine
subject: FOS: Health sciences

description: Supplemental material, sj-docx-1-han-10.1177_15589447221141485 for Type of Work and Preoperative Ability to Perform Work Affect Return to Usual Work Following Proximal Interphalangeal Joint Arthroplasty for Osteoarthritis by Bo J. W. Notermans, Joris S. Teunissen, Ruud W. Selles, Luitzen H. L. de Boer, the Hand Wrist Study Group and Brigitte E. P. A. van der Heijden in HAND
BIG DATA EN ENTREPRISE : QUELLES STRATEGIES D’IMPLANTATION ?
Creators: name: ZOUHRI, Mohammed
Publisher: name: Revue Economie, Gestion et Société
Year: 2016
Subjects: Information System, Business Intelligence, Big Data Strategy.

description: Ces dernières années, nous avons assisté à une croissance exponentielle dans le volume et la disponibilité des données. Ce fait résulte principalement de l'émergence d'une multitude de sources (ordinateurs, appareils mobiles, capteurs ou réseaux sociaux) qui produisent de manière continue des données structurées, semi-structurées ou non structurées. C’est l’ère du Big Data. Pour les entreprises, le Big Data constitue un nouveau défi puisqu’il implique de nouvelles exigences en termes de stockage de données, de traitement et de visualisation. L'analyse de ces données massives est d’une grande opportunité puisqu’elle permet de découvrir au sein de ces données des modèles et des corrélations originales. Cet article vise à apporter quelques éléments de réponse quant à la stratégie d’implantation du Big Data dans l’entreprise. Pour traiter cette question, nous rappelons l’évolution du processus d’informatisation des entreprises depuis les fameux mainframes jusqu’au Cloud Computing d’aujourd’hui. Ensuite, nous levons le voile sur le nouveau paradigme émergent du Big Data en termes de définitions, enjeux et défis. Enfin nous montrons que plusieurs stratégies d’adoption du Big Data sont possibles suivant l’existant en solutions analytiques et les besoins de l’entreprise.
description: Revue Economie, Gestion et Société, No 7 (2016)
Red blood cell distribution width and peritoneal dialysis-associated peritonitis prognosis
Creators: name: He, Peng
name: Hu, Jin-ping
name: Li, Huan
name: Tian, Xiu-juan
name: He, Li-jie
name: Sun, Shi-ren
name: Huang, Chen
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Mathematical Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Red blood cell distribution width (RDW) is a parameter of the heterogeneity of circulating erythrocyte size. Recent researches have pointed out a link among RDW, chronic kidney disease, and inflammation. We sought to investigate the prognostic value of baseline RDW in patients with peritoneal dialysis-associated peritonitis (PDAP). Our study included 337 peritonitis episodes experienced by 202 patients who were undergoing continuous ambulatory peritoneal dialysis (CAPD) at a single center from 2013 to 2018. Episodes were categorized according to the tertiles of baseline RDW levels (T1, <13.2%; T2, 13.2−14.3%; T3, >14.3%). Routine logistic regression and generalized estimating equation (GEE) were used to estimate the association between RDW and treatment failure, which was defined as relapse/recurrent episodes, catheter removal, or death during therapy. After adjusting for other potential predictors, RDW exhibited an incremental relationship with the risk of treatment failure. The baseline RDW of T3 indicated a 43% and 52% increased venture of treatment failure in logistic and GEE analyses, respectively, compared with T1. As a continuous variable, the fitting curve based on restricted cubic spiline showed that the relationship was nonlinearly but positively correlated. The multivariate model A (combined RDW with baseline age, albumin, serum ferritin, and duration on CAPD) showed an area under the curve of 0.671 (95% confidence interval, 0.5920.749) for the prediction of treatment failure. A Higher baseline level of RDW was significantly associated with a greater rate of treatment failure among PDAP episodes independent of other potential predictors.
The Internal History Of The Alor-Pantar Language Family
Creators: name: Holton, Gary
name: Robinson, Laura C.
Publisher: name: Zenodo
Year: 2017

description: This chapter demonstrates that the languages of Alor and Pantar share a common origin by applying the comparative method to primary lexical data from twelve languages sampled across the islands of the Alor-Pantar archipelago. More than one hundred proto-Alor-Pantar lexical items are reconstructed. An internal subgrouping based on shared phonological innovations is proposed and is compared to that derived using computational phylogenetic methods. It is argued that the Alor-Pantar group originally came from the region of the Pantar Strait.
sj-pdf-1-hum-10.1177_00187267221137872 – Supplemental material for Fast and spurious: How executives capture governance structures to prevent cooperativization
Creators: name: Bourlier-Bargues, Emilie
name: Gond, Jean-Pascal
name: Valiorgue, Bertrand
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business
subject: Sociology
subject: FOS: Sociology

description: Supplemental material, sj-pdf-1-hum-10.1177_00187267221137872 for Fast and spurious: How executives capture governance structures to prevent cooperativization by Emilie Bourlier-Bargues, Jean-Pascal Gond and Bertrand Valiorgue in Human Relations
Additional file 1 of Effectiveness of a positive psychology and mindfulness-based app on mental health for parents of children with a neurodevelopmental disorder: study protocol of a pragmatic international randomized controlled trial
Creators: name: Tönis, Kim J. M.
name: Drossaert, Constance H. C.
name: ten Klooster, Peter M.
name: Schaer, Marie
name: Bourgeron, Thomas
name: Buitelaar, Jan K.
name: Sadaka, Yair
name: Freitag, Christine M.
name: Lapidus, Keren Mayer
name: Chiocchetti, Andreas G.
name: Staal, Wouter G.
name: Bohlmeijer, Ernst T.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1.
Elevation In The Spatial Deictic Systems Of Alor-Pantar Languages
Creators: name: Schapper, Antoinette
Publisher: name: Zenodo
Year: 2017

description: This chapter provides a formal and semantic typology of the highly elaborate spatial deictic systems involving an elevation component found in the Alor-Pantar languages. The systems show a high degree of variation both in the number of paradigms of elevation-marked terms as well as in the number of semantic components within the different elevational domains. The chapter further considers the history and reconstructability of an elevational system to proto-Alor-Pantar, observing that the elevation distinction itself is very stable in the deictic systems of the AP languages, but that the terms of the systems are not always stable and that the systems are often subject to elaboration.
Numeral Words And Arithmetic Operations In The Alor-Pantar Languages
Creators: name: Klamer, Marian
name: Schapper, Antoinette
name: Corbett, Greville
name: Holton, Gary
name: Kratochvíl, František
name: Robinson, Laura C.
Publisher: name: Zenodo
Year: 2017

description: The indigenous numerals of the AP languages, as well as the indigenous structures for arithmetic operations are currently under pressure from Indonesian, and will inevitably be replaced with Indonesian forms and structures.

This chapter presents a documentary record of the forms and patterns currently in use to express numerals and arithmetic operations in the Alor-Pantar languages. We describe the structure of cardinal, ordinal and distributive numerals, and how operations of addition, subtraction, multiplication, division, and fractions are expressed.
Caregivers navigating rehabilitative care for people with aphasia after stroke: a multi-lens perspective
Creators: name: Haley, Katarina L.
name: Shafer, Paul R.
name: Shafer, Jennifer S.
Publisher: name: Wiley
Year: 2019

description: BACKGROUND: Up to 40% of stroke survivors acquire aphasia and require long-term caregiver assistance after discharge from the hospital. Caregivers assume multiple roles as they help people with aphasia to access outpatient rehabilitative care in an increasingly person-centred model of care. Examining caregiver roles and how different stakeholders in the rehabilitative journey perceive these roles may be the first step in providing more tailored support to caregivers and improving outcomes for both caregivers and people with aphasia. AIMS: To characterize the roles caregivers assume while navigating outpatient rehabilitative care for people with aphasia after stroke from the perspective of different stakeholders in the rehabilitative process. METHODS & PROCEDURES: Thirty-six people participated in the study, including seven caregivers, 22 stroke survivors with aphasia and seven healthcare providers. Focus groups were conducted, and an iterative thematic analysis was used to identify themes. OUTCOMES & RESULTS: Results indicate that caregivers are perceived differently by varying stakeholders, and that caregivers adopt diverse roles as advocates, therapists, motivators and guardians. They assume these roles in order to fill gaps in services or otherwise to facilitate the recovery journey for the person with aphasia. CONCLUSIONS & IMPLICATIONS: This study provides a valuable glimpse into how varying stakeholders view the role of the caregiver during rehabilitation for people with aphasia after stroke. Providing caregivers with the training and support they need throughout the recovery journey by treating them as partners in the process may mitigate the perception of caregivers as feeling compelled to adopt multiple roles.
First Ever Ionization Cooling Demonstration In Mice
Creators: name: WHYTE, Colin
Publisher: name: Zenodo
Year: 2018

description: The Muon Ionization Cooling Experiment (MICE) at RAL has studied the ionization cooling of muons. Several million individual particle tracks have been recorded passing through a series of focusing magnets in a number of different configurations and a liquid hydrogen or lithium hydride absorber. Measurement of the tracks upstream and downstream of the absorber has shown the expected effects of the 4D emittance reduction. This invited talk presents and discusses these results, and projects the future of ionization cooling.
Supplemental Material—Relationship Between Serum Uric Acid and Carotid Plaque in Patients With Coronary Artery Disease by Sex and Blood Pressure Status
Creators: name: Pan, Guangwei
name: Liu, Yijia
name: Yu, Lu
name: Yang, Rongrong
name: Yang, Tong
name: Wang, Yang
name: Su, Jinyu
name: Li, Zhu
name: Cheng, Qi
name: Gao, Sheng
name: Li, Lin
name: Yu, Chunquan
Publisher: name: SAGE Journals
Year: 2023
Subjects: Cardiology

description: Supplemental Material for Relationship Between Serum Uric Acid and Carotid Plaque in Patients With Coronary Artery Disease by Sex and Blood Pressure Status by Guangwei Pan, Yijia Liu, Lu Yu, Rongrong Yang, Tong Yang, Yang Wang, Jinyu Su, Zhu Li, Qi Cheng, Sheng Gao, Lin Li, and Chunquan Yu in Angiology.
Perspectives on Research Participation and Facilitation Among Dialysis Patients, Clinic Personnel, and Medical Providers: A Focus Group Study
Creators: name: Dember, Laura M.
name: Narendra, Julia H.
name: Flythe, Jennifer E.
name: Dorough, Adeline
name: Wilkie, Caroline
name: Oberlander, Jonathan
name: Ordish, Antoinette
Publisher: name: Elsevier
Year: 2017

description: BACKGROUND: Most prospective studies involving individuals receiving maintenance dialysis have been small, and many have had poor clinical translatability. Research relevance can be enhanced through stakeholder engagement. However, little is known about dialysis clinic stakeholders' perceptions of research participation and facilitation. The objective of this study was to characterize the perspectives of dialysis clinic stakeholders (patients, clinic personnel, and medical providers) on: (1) research participation by patients and (2) research facilitation by clinic personnel and medical providers. We also sought to elucidate stakeholder preferences for research communication. STUDY DESIGN: Qualitative study. SETTING & PARTICIPANTS: 7 focus groups (59 participants: 8 clinic managers, 14 nurses/patient care technicians, 8 social workers/dietitians, 11 nephrologists/advanced practice providers, and 18 patients/care partners) from 7 North Carolina dialysis clinics. METHODOLOGY: Clinics and participants were purposively sampled. Focus groups were recorded and transcribed. ANALYTICAL APPROACH: Thematic analysis. RESULTS: We identified 11 themes that captured barriers to and facilitators of research participation by patients and research facilitation by clinic personnel and medical providers. We collapsed these themes into 4 categories to create an organizational framework for considering stakeholder (narrow research understanding, competing personal priorities, and low patient literacy and education levels), relationship (trust, buy-in, and altruistic motivations), research design (convenience, follow-up, and patient incentives), and dialysis clinic (professional demands, teamwork, and communication) aspects that may affect stakeholder interest in participating in or facilitating research. These themes appear to shape the degree of research readiness of a dialysis clinic environment. Participants preferred short research communications delivered in multiple formats. LIMITATIONS: Potential selection bias and inclusion of English-speaking participants only. CONCLUSIONS: Our findings revealed patient interest in participating in research and clinical personnel and medical provider interest in facilitating research. Overall, our results suggest that dialysis clinic research readiness may be enhanced through increased stakeholder research knowledge and alignment of clinical and research activities.
Neutrino Interaction Model Tuning At Nova
Creators: name: MISLIVEC, Aaron
Publisher: name: Zenodo
Year: 2018

description: The NOvA neutrino oscillation experiment uses the GENIE event generator to predict neutrino interactions in its detectors. Recent data, recent reanalysis of extant data, and continued development of theoretical models have brought to light deficiencies in the default GENIE cross section model, which in turn impact the predicted spectra used to infer oscillation parameters. We discuss modifications to GENIE version 2.12.2, motivated by these various sources, which culminate in a tune using NOvA near detector muon neutrino scattering data. This tuned version of the generator is used for the predictions in NOvA's far detector oscillation analyses.
sj-pdf-11-hpq-10.1177_13591053231184032 – Supplemental material for “God wastes nothing”: A consensual qualitative study of coping among Catholic individuals with cancer diagnoses
Creators: name: Shannonhouse, Laura
name: Lopez, Jorge
name: Hall, M Elizabeth Lewis
name: Silverman, Eric
name: Captari, Laura E
name: Park, Crystal L
name: McMartin, Jason
name: Kapic, Kelly
name: Aten, Jamie
Publisher: name: SAGE Journals
Year: 2023
Subjects: classificationCode: 170199
subject: Psychology not elsewhere classified
classificationCode: 110319
subject: Psychiatry (incl. Psychotherapy)
classificationCode: 111799
subject: Public Health and Health Services not elsewhere classified

description: Supplemental material, sj-pdf-11-hpq-10.1177_13591053231184032 for “God wastes nothing”: A consensual qualitative study of coping among Catholic individuals with cancer diagnoses by Laura Shannonhouse, Jorge Lopez, M Elizabeth Lewis Hall, Eric Silverman, Laura E Captari, Crystal L Park, Jason McMartin, Kelly Kapic and Jamie Aten in Journal of Health Psychology
LE MANAGEMENT DES CONNAISSANCES : QUEL ETAT DES LIEUX DANS L’ENTREPRISE MAROCAINE ?
Creators: name: AMMARCHA, Aouatef
name: YASSAFI, Moussa
Publisher: name: Revue Economie, Gestion et Société
Year: 2016
Subjects: Explicit and tacit knowledge - knowledge management - Knowledge capitalization - KM in the Moroccan company.

description: Dans une approche de management stratégique basé sur le capital immatériel, s’est développé un courant de réflexion autour du concept management des connaissances. Ce courant considère l’importance des connaissances et du savoir dans le développement stratégique des organisations. Pour mieux exploiter cette ressource immatérielle, une méthode de management a été adoptée par les grandes entreprises, appelée Knowledge Management (traduit en français par gestion des connaissances ou management des connaissances). C’est une méthode qui vise la préservation, l'exploitation, la diffusion et le partage du savoir et du savoir faire générés au sein de l’organisation. L’objectif de ce papier est de présenter le management des connaissances, en tant qu’une démarche qui permet l’exploitation d’une partie importante de la richesse immatérielle des organisations, la connaissance. Je vais essayer de traiter la problématique de la mise en place d’une vraie démarche KM dans le contexte de l’entreprise marocaine via une étude qualitative basée sur des entretiens semi-directifs réalisés avec des experts en stratégies de gestions des ressources humaines. Le but est de savoir si l’entreprise marocaine pratique ou non, efficacement ou non efficacement, le management des connaissances.
description: Revue Economie, Gestion et Société, No 6 (2016)
Comprehensive assessment of deceased donor kidneys with clinical characteristics, pre-implant biopsy histopathology and hypothermic mechanical perfusion parameters is highly predictive of delayed graft function
Creators: name: Zheng, Jin
name: Hu, Xiaojun
name: Ding, Xiaoming
name: Li, Yang
name: Ding, Chenguang
name: Tian, Puxun
name: Xiang, Heli
name: Feng, Xinshun
name: Pan, Xiaoming
name: Yan, Hang
name: Hou, Jun
name: Tian, Xiaohui
name: Liu, Zunwei
name: Wang, Xuzhen
name: Xue, Wujun
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Due to the current high demand for transplant tissue, an increasing proportion of kidney donors are considered extended criteria donors, which results in a higher incidence of delayed graft function (DGF) in organ recipients. Therefore, it is important to fully investigate the risk factors of DGF, and establish a prediction system to assess donor kidney quality before transplantation. A total of 333 donation after cardiac death kidney transplant recipients were included in this retrospective study. Both univariate and multivariate analyses were used to analyze the risk factors of DGF occurrence. Receiver operating characteristic (ROC) curves were used to analyze the predictive value of variables on DGF posttransplant. The donor clinical scores, kidney histopathologic Remuzzi scores and hypothermic mechanical perfusion (HMP) parameters (flow and resistance index) were all correlated. 46 recipients developed DGF postoperatively, with an incidence of 13.8% (46/333). Multivariate logistic regression analysis of the kidney transplants revealed that the independent risk factors of DGF occurrence post-transplantation included donor score (OR = 1.12, 95% CI 1.06–1.19, p < 0.001), Remuzzi score (OR = 1.21, 95% CI 1.02–1.43, p = 0.029) and acute tubular injury (ATI) score (OR = 4.72, 95% CI 2.32–9.60, p < 0.001). Prediction of DGF with ROC curve showed that the area under the curve was increased to 0.89 when all variables (donor score, Remuzzi score, ATI score and HMP resistance index) were considered together. Combination of donor clinical information, kidney pre-implant histopathology and HMP parameters provide a more accurate prediction of DGF occurrence post-transplantation than any of the measures alone.