cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Approximation and Commutator Properties of Projections onto Shift-Invariant Subspaces and Applications to Boundary Integral Equations
Creators: name: Prössdorf, Siegfried
name: Schult, Jörg
Publisher: name: Weierstrass Institute
Year: 1997
Subjects: subject: Approximation property
subject: commutator property
subject: superapproximation property
subject: periodic pseudodifferential equations
subject: multiscaling functions
subject: multiwavelets
subject: splines with multiple knots
subject: Strang-Fix condition
subject: Galerkin-Petrov methods
subject: 41A05
subject: 41A15
subject: 41A17
subject: 45B05
subject: 45E10
subject: 45L10
subject: 45M10
subject: 65N12
subject: 65N35
subject: 65N38

description: The main purpose of the present paper is to prove approximation and commutator properties for projections mapping periodic Sobolev spaces onto shift-invariant spaces generated by a finite number of compactly supported functions. With these prerequisites at hand and using certain localization techniques, we then characterize the stability of generalized Galerkin-Petrov schemes for solving periodic pseudodifferential equations in terms of elliptic type estimates of the numerical symbol. Moreover, we establish optimal convergence rates for the approximate solutions with respect to the Sobolev norms.
Rektoratsrechnung vom Juni 1573 bis Juni 1574
Creators: name: Amerbach, Basilius
Publisher: name: [s.n.]
Year: 1573

description: Universität
description: Basilius Amerbach
description: Bl. 92a: leer
description: Kauf 1661 Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Verzeichnung=Description=Inventaire Mai 2015 Hans Berner
Resolving the bow shock and tail of the cannonball pulsar PSR J0002+6216
Creators: name: Kumar, P.
name: Schinzel, F. K.
name: Taylor, G. B.
name: Kerr, M.
name: Castro, D.
name: Rau, U.
name: Bhatnagar, S.
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present X-ray and radio observations of the recently-discovered bow shock pulsar wind nebula associated with PSR J0002+6216, characterizing the PWN morphology, which was unresolved in previous studies. The multi-frequency, multi-epoch Very Large Array radio observations reveal a cometary tail trailing the pulsar and extending up to 5.3', with multiple kinks along the emission. The presented radio continuum images from multi-configuration broadband VLA observations are one of the first results from the application of multi-term multi-frequency synthesis deconvolution in combination with the awproject gridder implemented in the Common Astronomy Software Applications package (CASA). The X-ray emission observed with Chandra extends to only 21'', fades quickly, and has some hot spots present along the extended radio emission. These kinks could indicate the presence of density variation in the local ISM or turbulence. The bow shock standoff distance estimates a small bow shock region with a size 0.003-0.009 pc, consistent with the pulsar spin-down power of Edot=1.51x10^35 ergs/s estimated from timing. The high-resolution radio image reveals the presence of an asymmetry in the bow shock region which is also present in the X-ray image. The broadband radio image shows an unusually steep spectrum along with a flat-spectrum sheath, which could indicate varying opacity or energy injection into the region. Spatially-resolved X-ray spectra provide marginal evidence of synchrotron cooling along the extended tail. Our analysis of the X-ray data also shows that this pulsar has a low spin-down power and one of the lowest X-ray efficiencies observed in these objects.
description: 15 pages, 7 figures Accepted for publication in ApJ
Model based design of super schedulers managing catastrophic scenario in hard real time systems
Creators: name: Persya, A. Christy
name: Nair, T. R. Gopalakrishnan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Computer and information sciences

description: The conventional design of real-time approaches depends heavily on the normal performance of systems and it often becomes incapacitated in dealing with catastrophic scenarios effectively. There are several investigations carried out to effectively tackle large scale catastrophe of a plant and how real-time systems must reorganize itself to respond optimally to changing scenarios to reduce catastrophe and aid human intervention. The study presented here is in this direction and the model accommodates catastrophe generated tasks while it tries to minimize the total number of deadline miss, by dynamically scheduling the unusual pattern of tasks. The problem is NP hard. We prove the methods for an optimal scheduling algorithm. We also derive a model to maintain the stability of the processes. Moreover, we study the problem of minimizing the number of processors required for scheduling with a set of periodic and sporadic hard real time tasks with primary/backup mechanism to achieve fault tolerance. EDF scheduling algorithms are used on each processor to manage scenario changes. Finally we present a simulation of super scheduler with small, medium and large real time tasks pattern for catastrophe management.
description: 7 pages, 4 figures,Information Communication and Embedded Systems (ICICES), 2013, IEEE International Conference on, Chennai, India, pp.1149,1155, 21-22 Feb. 2013
Ultrafast Rabi oscillation of a Gaussian atom ensemble
Creators: name: Lee, Han-gyeol
name: Kim, Hyosub
name: Ahn, Jaewook
Publisher: name: arXiv
Year: 2014
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: We investigate Rabi oscillation of an atom ensemble in Gaussian spatial distribution. By using the ultrafast laser interaction with the cold atomic rubidium vapor spatially confined in a magneto-optical trap, the oscillatory behavior of the atom excitation is probed as a function of the laser pulse power. Theoretical model calculation predicts that the oscillation peaks of the ensemble-atom Rabi flopping fall on the simple Rabi oscillation curve of a single atom and the experimental result shows good agreement with the prediction. We also test the the three-pulse composite interaction $R_x(π/2)R_y(π)R_x(π/2)$ to develop a robust method to achieve a higher fidelity population inversion of the atom ensemble.
description: 5 pages, 4 figures
Tracking Non-Radial Outflows in Extreme Ultraviolet and White Light Solar Images
Creators: name: Alzate, Nathalia
name: Morgan, Huw
name: Di Matteo, Simone
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: Understanding the solar corona requires knowledge of its dynamics through its various layers and subsequent connectivity to the heliosphere. This requires understanding the nature of the outflows and the physical transitions through the middle corona (~1.5-6.0 Rs). While this region is still inaccessible to in situ measurements, remote sensing observations are available, but their interpretation can be controversial due to line-of-sight effects and the non-radial motion of outflowing structures close to the Sun (<3.0 Rs). In this work, we describe a method to mitigate these challenges by generating non-radial Height-Time profiles of outflows by using advanced image processing techniques. The North and South boundaries of a large equatorial streamer during the 2008 solar minimum were identified in STEREO/SECCHI solar images, using two different methodologies based on thresholds of brightness and piece-wise polynomial function fitting. To address line-of-sight issues, we used tomographic reconstruction of the 3D distribution of the coronal electron density based on SECCHI/COR2 images. Spectral analysis of the time series of the position angle of the streamer boundary revealed its oscillatory nature at some heights at 36-48 hours and 10.5-14.6 hours. Dividing the distance between the North and South streamer boundaries in equal parts at each height, we obtained non-radial Height-Time paths from which we generated non-radial profiles of corona/solar wind plasma outflow. We tracked outflows as they moved uninterruptedly from the Sun in EUVI, through COR1 and into COR2. Finally, we discuss preliminary results of non-radial plane-of-sky velocities for a CME and two small-scale features.
Dissipation dynamics and spin-orbit force in time-dependent Hartree-Fock theory
Creators: name: Dai, Gao-Feng
name: Guo, Lu
name: Zhao, En-Guang
name: Zhou, Shan-Gui
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We investigate the one-body dissipation dynamics in heavy-ion collisions of $^{16}{\rm O}$+$^{16}{\rm O}$ using a fully three-dimensional time-dependent Hartree-Fock (TDHF) theory with the modern Skyrme energy functional and without any symmetry restrictions. The energy dissipation is revealed to decrease in deep-inelastic collisions of the light systems as the bombarding energy increases owing to the competition between collective motion and single-particle degrees of freedom. The role of spin-orbit force is given particular emphasis in deep-inelastic collisions. The spin-orbit force causes a significant enhancement of the dissipation. The time-even coupling of spin-orbit force plays a dominant role at low energies, while the influence of time-odd terms is notable at high energies. About 40-65\% of the total dissipation depending on the different parameter sets is predicted to arise from the spin-orbit force. The theoretical fusion cross section has a reasonably good agreement with the experimental data, considering that no free parameters are adjusted to reaction dynamics in the TDHF approach.
description: accepted for publication in Phys. Rev. C
Phosphorylation landscape of infection-related development reveals novel virulence determinants during rice blast disease
Creators: name: Cruz-Mireles, Neftaly
name: Osés-Ruiz, Miriam
name: Derbyshire, Paul
name: Jégousse, Clara
name: Ryder, Lauren S.
name: Bautista, Mark Jave
name: Eseola, Alice
name: Sklenar, Jan
name: Bozeng Tang
name: Yan, Xia
name: Weibin Ma
name: Findlay, Kim C.
name: Were, Vincent
name: MacLean, Dan
name: Talbot, Nicholas J.
name: Menke, Frank L.H.
Publisher: name: Zenodo
Year: 2023
Subjects: Appressorium, Pmk1 pathway, protein phosphorylation, phosphoproteomics

description: Rice blast, caused by Magnaporthe oryzae, is among the most devastating fungal diseases affecting agriculture worldwide. The blast fungus enters plant cells using a specialised dome-shaped structure called an appressorium, which requires the Pmk1 MAP kinase for its morphogenesis. Although the Pmk1 pathway controls phosphorylation changes in the appressorium, little is known about the phosphorylation events on the fungal proteins. Here, we report the phosphorylation landscape of early appressorium morphogenesis in the blast fungus. Using MS1 analysis from a time series study of appressorium samples, we mapped 5,737 phosphosites corresponding to 2,101 proteins. This approach reveals a dramatic rewiring of phosphorylation during early appressorium development. Furthermore, using quantitative phosphoproteomic analysis, we identified 33 putative direct downstream targets of the Pmk1 MAPK during plant infection. One of the targets, named Vts1, is phosphorylated by Pmk1 at two proline-directed sites. Targeted mutation showed that Vts1 is necessary for mycelium growth, sporulation, appressorium development and pathogenicity. Additionally, Vts1 phosphomimetic and phosphodead mutants demonstrated the importance of its phosphorylation. Taken together, our results show how quantitative phosphoproteomics can identify novel regulators, such as Vts1, which are essential for rice blast disease.
Trans-Tasman variation in Australasian Filinia populations
Creators: name: Shiel, Russell J
name: Sanoamuang, La-orsri
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

Morphological comparisons of populations of Filinia from New Zealand and Australia established the presence of an undescribed species in Lake Okaro, N.Z. Filinia novaezealandiae n. sp. is described. SEM micrographs of trophi were used to distinguish closely allied Filinia species. Filinia grandis comb. nov. is redescribed from Australia on the basis of trophi differences from F. pejleri. It is suggested that Filinia species may be more restricted than global records indicate; these records reflect the distribution of authoritative taxonomic references, not necessarily the animals they depict.
Abrechnung über Zahlungen an Basilius Amerbach während dessen Aufenthalt in Italien
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1554
Subjects: Amerbach, Basilius1533-1591BasiliusAmerbach

description: Mit Quittierung von der Hand des Basilius Amerbach vom 7. Juli 1555
description: Kauf 1661 Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Verzeichnung=Description=Inventaire Mai 2015 Hans Berner
Parameters of cosmological models and recent astronomical observations
Creators: name: Sharov, G. S.
name: Vorontsova, E. G.
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: For different gravitational models we consider limitations on their parameters coming from recent observational data for type Ia supernovae, baryon acoustic oscillations, and from 34 data points for the Hubble parameter $H(z)$ depending on redshift. We calculate parameters of 3 models describing accelerated expansion of the universe: the $Λ$CDM model, the model with generalized Chaplygin gas (GCG) and the multidimensional model of I. Pahwa, D.~Choudhury and T.R.~Seshadri. In particular, for the $Λ$CDM model $1σ$ estimates of parameters are: $H_0=70.262\pm0.319$ km\,c${}^{-1}$Mpc${}^{-1}$, $Ω_m=0.276_{-0.008}^{+0.009}$, $Ω_Λ=0.769\pm0.029$, $Ω_k=-0.045\pm0.032$. The GCG model under restriction $α\ge0$ is reduced to the $Λ$CDM model. Predictions of the multidimensional model essentially depend on 3 data points for $H(z)$ with $z\ge2.3$.
description: 18 pages, 4 figures
Abrechnungen u.a. von Adam Henricpetri über Schulden, die er dem Fiskus der Juristenfakultät zurückliess
Creators: name: Amerbach, Basilius
name: Henricpetri, Adam
name: Grynäus, Samuel
Publisher: name: [s.n.]
Year: 1575

description: Universität
description: Adam Henricpetri, Basilius Amerbach, Samuel Grynaeus
description: Kauf 1661 Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Verzeichnung=Description=Inventaire Mai 2015 Hans Berner
Experimental testing of steel box straddle caps for evaluation of internal redundancy
Creators: name: Williams, Emma C., 1998-
Publisher: name: The University of Texas at Austin
Year: 2022
Subjects: Fracture critical
Straddle cap
Internal redundancy
Redundancy

description: The work outlined in this thesis is a part of a larger study on the development of details to provide internal redundancy to steel box straddle caps which are currently classified as fracture critical members. This study is funded by the Texas Department of Transportation (TxDOT 0-7012). The fundamental goal of this investigation is to develop and evaluate box section details which will no longer carry the stringent inspection requirements of fracture critical members. Additionally, researchers will produce design examples for the implementation of these details. This work includes laboratory testing and parametric FEA studies. The experimental testing involves evaluating the performance of the selected details during the propagation of a brittle fracture and the capacity of the system after the fracture has occurred. The data from the experimental testing will be used to validate parametric FEA models. These models will be used to evaluate the behavior of various arrangements and applications of the developed details. This thesis focuses on the experimental testing of the small-scale pilot specimens and the large-scale baselines specimen, which possessed no detailing for redundancy. It includes the documentation of the fatigue crack growth and brittle fracture propagation procedures implemented on this study.
Non-Markovian dynamics with fermions
Creators: name: Sargsyan, V. V.
name: Adamian, G. G.
name: Antonenko, N. V.
name: Lacroix, D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Employing the quadratic fermionic Hamiltonians for the collective and internal subsystems with a linear coupling, we studied the role of fermionic statistics on the dynamics of the collective motion. The transport coefficients are discussed as well as the associated fluctuation-dissipation relation. Due to different nature of the particles, the path to equilibrium is slightly affected. However, in the weak coupling regime, the time-scale for approaching equilibrium is found to be globally unchanged. The Pauli-blocking effect can modify the usual picture in open quantum system. In some limits, contrary to boson, this effect can strongly hinder the influence of the bath by blocking the interacting channels.
description: 13 pages, 6 figures. Submitted to PRA
SNF5 Reexpression in Malignant Rhabdoid Tumors Regulates Transcription of Target Genes by Recruitment of SWI/SNF Complexes and RNAPII to the Transcription Start Site of Their Promoters
Creators: name: Kuwahara, Yasumichi
name: Durand, Joel
name: Weissman, Bernard E.
name: Wei, Darmood
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Malignant rhabdoid tumor (MRT), a highly aggressive cancer of young children, displays inactivation or loss of the hSNF5/INI1/SMARCB1 gene, a core subunit of the SWI/SNF chromatin-remodeling complex, in primary tumors and cell lines. We have previously reported that reexpression of hSNF5 in some MRT cell lines causes a G1 arrest via p21CIP1/WAF1 (p21) mRNA induction in a p53-independent manner. However, the mechanism(s) by which hSNF5 reexpression activates gene transcription remains unclear. We initially searched for other hSNF5 target genes by asking whether hSNF5 loss altered regulation of other consensus p53 target genes. Our studies show that hSNF5 regulates only a subset of p53 target genes, including p21 and NOXA, in MRT cell lines. We also show that hSNF5 reexpression modulates SWI/SNF complex levels at the transcription start site (TSS) at both loci and leads to activation of transcription initiation through recruitment of RNA polymerase II (RNAPII) accompanied by H3K4 and H3K36 modifications. Furthermore, our results show lower NOXA expression in MRT cell lines compared with other human tumor cell lines, suggesting that hSNF5 loss may alter the expression of this important apoptotic gene. Thus, one mechanism for MRT development after hSNF5 loss may rely on reduced chromatin-remodeling activity of the SWI/SNF complex at the TSS of critical gene promoters. Furthermore, because we observe growth inhibition after NOXA expression in MRT cells, the NOXA pathway may provide a novel target with clinical relevancy for treatment of this aggressive disease.
On the Spectral Evolution of Hot White Dwarf Stars. IV. The Diffusion and Mixing of Residual Hydrogen in Helium-rich White Dwarfs
Creators: name: Bédard, A.
name: Bergeron, P.
name: Brassard, P.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: In the framework of our extensive modeling study of the spectral evolution of white dwarfs, we present here a new set of detailed calculations of the transport of residual hydrogen in helium-rich white dwarfs. First, we investigate the so-called float-up process at high effective temperature, whereby the upward diffusion of trace hydrogen leads to the formation of a hydrogen atmosphere. We examine the dependence of this phenomenon on the initial hydrogen abundance and on the strength of the radiative wind that opposes gravitational settling. Combined with our empirical knowledge of spectral evolution, our simulations provide new quantitative constraints on the hydrogen content of the hot helium-dominated white dwarf population. Then, we study the outcome of the so-called convective dilution process at low effective temperature, whereby the superficial hydrogen layer is mixed within the underlying helium-rich envelope. In stark contrast with previous works on convective dilution, we demonstrate that, under reasonable assumptions, our models successfully reproduce the observed atmospheric composition of cool DBA stars, thereby solving one of the most important problems of spectral evolution theory. This major improvement is due to our self-consistent modeling of the earlier float-up process, which predicts the existence of a massive hydrogen reservoir underneath the thin superficial layer. We argue that the trace hydrogen detected at the surface of DBA white dwarfs is, in most cases, of primordial origin rather than the result of external accretion.
description: 21 pages, 9 figures, accepted for publication in The Astrophysical Journal
Anomalous surface states at interfaces in p-wave superconductors
Creators: name: Bakurskiy, S. V.
name: Golubov, A. A.
name: Kupriyanov, M. Yu.
name: Yada, K.
name: Tanaka, Y.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We present the results of theoretical study of surface state properties in a two-dimensional model for triplet $p$-wave superconductors. We derive boundary conditions for Eilenberger equations at rough interfaces and develop the approach for self-consistent solution for the spatial dependence of $p_{x}$ and $p_{x}+i~p_{y}$ -wave pair potentials. In the $p_{x}$ case we demonstrate the robustness of the zero-energy peak in the density of states (DoS) with respect to surface roughness, in contrast to the suppression of such a peak in the case of $d_{xy}$ symmetry. This effect is due to stability of odd-frequency pairing state at the surface with respect to disorder. In the case of the chiral $p_{x}+i~p_{y}$ state we demonstrate the appearance of a complex multi-peak subgap structure in the spectrum with increasing surface roughness.
description: 11 pages, 10 figures, accepted to Physical Review B
C-C Chemokine Receptor 5 on Pulmonary Mesenchymal Cells Promotes Experimental Metastasis via the Induction of Erythroid Differentiation Regulator 1
Creators: name: Wu, Qing Ping
name: Mango, Robert L.
name: West, Michelle
name: Serody, Jonathan S.
name: McCook, Everett C.
name: van Deventer, Hendrik W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: C-C Chemokine receptor five knockout (Ccr5-/-) mice develop fewer experimental pulmonary metastases than wild type (WT) mice. This phenomenon was explored by applying gene-expression profiling to the lungs of mice with these metastases. Consequently, Erythroid Differentiation Regulator 1 (Erdr1) was identified as upregulated in the WT mice. Though commonly associated with bone marrow stroma, Erdr1 was differentially expressed in WT pulmonary mesenchymal cells (PMCs) and murine embryonic fibroblasts (MEFs). Moreover, the Ccr5 ligand Ccl4 increased its expression by 3.36 ± 0.14 fold. Ccr5 signaling was dependent on the Map2k but not the Pi3k pathway since treatment with U0126 inhibited upregulation of Erdr1 but treatment with LY294002 increased the expression by 3.44 ± 0.92 fold (p < 0.05). Erdr1's effect on B16-F10 melanoma metastasis was verified by the adoptive transfer of WT MEFs into Ccr5-/- mice. In this model, MEFs that had been transduced with Erdr1 shRNA lowered metastasis by 33% compared to control transduced MEFs. The relevance of ERDR1 on human disease was assessed by co-culturing chronic lymphocytic leukemia (CLL) cells with M2-10B4 stromal cells that had been transfected with shRNA or control plasmids. After 96 hours of co-culture, the cell counts were higher with control cell lines compared with Erdr1 knockdown lines (OR 1.88 ± 0.27, 2.52 ± 0.66 respectively). This increase was associated with a decrease in apoptotic cells (OR 0.69 ± 0.18, 0.58 ± 0.12 respectively).
Gene Silencing Associated with SWI/SNF Complex Loss during NSCLC Development
Creators: name: Smiraglia, Dominic J.
name: Plass, Christoph
name: Karaca, Mehmet
name: Zheng, Yanfang
name: Bartlett, Christopher S.
name: Serber, Daniel
name: Song, Shujie
name: Weissman, Bernard E.
name: Hayes, D. Neil
name: Zhang, Jiren
name: Sproul, Christopher D.
name: Li, Ying
name: Walter, Vonn
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The SWI/SNF chromatin-remodeling complex regulates gene expression and alters chromatin structures in an ATP-dependent manner. Recent sequencing efforts have shown mutations in BRG1 (SMARCA4), one of two mutually exclusive ATPase subunits in the complex, in a significant number of human lung tumor cell lines and primary non-small cell lung carcinoma (NSCLC) clinical specimens. To determine how BRG1 loss fuels tumor progression in NSCLC, molecular profiling was performed after restoration of BRG1 expression or treatment with an HDAC inhibitor or a DNMT inhibitor in a BRG1-deficient NSCLC cells. Importantly, validation studies from multiple cell lines revealed that BRG1 re-expression led to substantial changes in the expression of CDH1, CDH3, EHF and RRAD that commonly undergo silencing by other epigenetic mechanisms during NSCLC development. Furthermore, treatment with DNMT inhibitors did not restore expression of these transcripts indicating that this common mechanism of gene silencing did not account for their loss of expression. Collectively, BRG1 loss is an important mechanism for the epigenetic silencing of target genes during NSCLC development.
Dekanatsrechnung vom Juni 1583 bis Juni 1584
Creators: name: Amerbach, Basilius
Publisher: name: [s.n.]
Year: 1583

description: Universität
description: Basilius Amerbach
description: Bl. 106a: leer
description: Kauf 1661 Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Verzeichnung=Description=Inventaire Mai 2015 Hans Berner
PTEN Deficiency Mediates a Reciprocal Response to IGFI and mTOR Inhibition
Creators: name: Sapp, Travis
name: Wu, Sam
name: Smith, Scott V.
name: Moats-Staats, Billie M.
name: Rojas, Andres
name: Davis, Ian J.
name: Patel, Mukund
name: Gomez, Nicholas C.
name: Simon, Jeremy M.
name: Kaiser-Rogers, Kathleen
name: McFadden, Andrew W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Recent evidence implicates the insulin-like growth factor (IGF) pathway in development of Ewing Sarcoma, a highly malignant bone and soft tissue tumor that primarily affects children and young adults. Despite promising results from preclinical studies of therapies that target this pathway, early phase clinical trials have shown that a significant fraction of patients do not benefit, suggesting that cellular factors determine tumor sensitivity. Using FAIRE-seq, a chromosomal deletion of the PTEN locus in a Ewing sarcoma cell line was identified. In primary tumors PTEN deficiency was observed in a large subset of cases, although not mediated by large chromosomal deletions. PTEN loss resulted in hyper-activation of the AKT signaling pathway. PTEN rescue led to decreased proliferation, inhibition of colony formation, and increased apoptosis. Strikingly, PTEN loss decreased sensitivity to IGF-1R inhibitors but increased responsiveness to temsirolimus, a potent mTOR inhibitor, as marked by induction of autophagy. These results suggest that PTEN is lost in a significant fraction of primary tumors and this deficiency may have therapeutic consequences by concurrently attenuating responsiveness to IGF-1R inhibition while increasing activity of mTOR inhibitors. The identification of PTEN status in the tumors of patients with recurrent disease could help guide the selection of therapies.
Il Liutaio nel Bazaar. Un viaggio nel tempo e nel digitale [poster]
Il Liutaio nel Bazaar. Un viaggio nel tempo e nel digitale [poster]
Creators: name: Ivković, Rebecca
Publisher: name: R. Ivković, "Il Liutaio nel Bazaar. Un viaggio nel tempo e nel digitale", in Book of Abstract AIPH 2022, Quarta Conferenza Nazionale di Public History, Storia bene comune, Università Ca’ Foscari Venezia, M9 – Museo del ’900. Venezia-Mestre, 27-31 maggio 2022.
Year: 2025

description: Il Liutaio nel Bazaar si propone di costruire un ponte fra il mondo accademico e il pubblico più ampio, creando uno spazio condiviso aperto a studenti, docenti, ricercatori e appassionati della materia. Il progetto intende, inoltre, promuovere la conoscenza e lo studio della storia a un pubblico non specialistico attraverso l'uso di discorsi chiari e accessibili coniugati alla serietà e al rigore scientifici. Un ulteriore obiettivo del progetto consiste nell'incoraggiare lo studio della storia da una prospettiva interdisciplinare aperta all'indagine di differenti tematiche che includono diverse aree geografiche e altrettante periodizzazioni
title: Leaving, staying in and returning to the hometown
title: couples’ residential location choices at the time of family formation
titleType: AlternativeTitle
Creators: name: Albrecht, Janna
name: Scheiner, Joachim
Publisher: name: TU Dortmund
Year: 2022
Subjects: subject: Residential choice
subject: Residential biography
subject: Intergenerational family ties
subject: Return migration
subject: Family formation
subject: 710
subject: Wohnen |
subject: Rückwanderung |
subject: Familie
subject: Heimatort |

description: Couples' residential decisions are based on a large variety of factors including housing preferences, family and other social ties, socialisation and residential biography (e.g. earlier experience in the life course) and environmental factors (e.g. housing market, labour market). This study examines, firstly, to what extent people stay in, return to or leave their hometown (referred to as ‘migration type’). We refer to the hometown as the place where most of childhood and adolescence is spent. Secondly, we study which conditions shape a person’s migration type. We mainly focus on variables capturing elements of the residential biography and both partners’ family ties and family socialisation. We focus on the residential choices made at the time of family formation, i.e. when the first child is born. We employ multinomial regression modelling and cross-tabulations, based on two generations in a sample of families who mostly live in the wider Ruhr area, born around 1931 (parents) and 1957 (adult children). We find that migration type is significantly affected by a combination of both partners' place of origin, both partners' parents' places of residence, the number of previous moves, level of education and hometown population size. We conclude that complex patterns of experience made over the life course, socialisation and gendered patterns are at work. These mechanisms should be kept in mind when policymakers develop strategies to attract (return) migrants.
description: Raumforschung und Raumordnung;Bd 80. 2022, H. 4, S. 414-433
SNF5/INI1 Deficiency Redefines Chromatin Remodeling Complex Composition during Tumor Development
Creators: name: Emanuele, Michael
name: Yan, Feng
name: Goldfarb, Dennis
name: Weissman, Bernard E.
name: Kuwahara, Yasumichi
name: Song, Shujie
name: Major, Michael B.
name: Wei, Darmood
name: Sakellariou-Thompson, Donastas
name: Cannon, Courtney
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Malignant Rhabdoid Tumors (MRTs), a pediatric cancer that most frequently appears in the kidney and brain, generally lack SNF5 (SMARCB1/INI1), a subunit of the SWI/SNF chromatin-remodeling complex. Recent studies have established that multiple SWI/SNF complexes exist due to the presence or absence of different complex members. Therefore, the effect of SNF5 loss upon SWI/SNF complex formation was investigated in human MRT cells. MRT cells and primary human tumors exhibited reduced levels of many complex proteins. Furthermore, re-expression of SNF5 increased SWI/SNF complex protein levels without concomitant increases in mRNA. Proteomic analysis, using mass spectrometry, of MRT cells before and after SNF5 re-expression indicated the recruitment of different components into the complex along with the expulsion of others. IP-Western blotting confirmed these results and demonstrated similar changes in other MRT cell lines. Finally, reduced expression of SNF5 in normal human fibroblasts led to altered levels of these same complex members. These data establish that SNF5 loss during MRT development alters the repertoire of available SWI/SNF complexes, generally disrupting those associated with cellular differentiation. These findings support a model where SNF5 inactivation blocks the conversion of growth promoting SWI/SNF complexes to differentiation inducing ones. Therefore, restoration of these complexes in tumors cells provides an attractive approach for the treatment of malignant rhabdoid tumors.
Diffractive wave guiding of hot electrons by the Au (111) herringbone reconstruction
Creators: name: Libisch, F.
name: Geringer, V.
name: Subramaniam, D.
name: Burgdörfer, J.
name: Morgenstern, M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The surface potential of the herringbone reconstruction on Au(111) is known to guide surface-state electrons along the potential channels. Surprisingly, we find by scanning tunneling spectroscopy that hot electrons with kinetic energies twenty times larger than the potential amplitude (38 meV) are still guided. The efficiency even increases with kinetic energy, which is reproduced by a tight binding calculation taking the known reconstruction potential and strain into account. The guiding is explained by diffraction at the inhomogeneous electrostatic potential and strain distribution provided by the reconstruction.
description: 10 pages, 9 figures
On Time chez Dummett
Creators: name: Butterfield, Jeremy
Publisher: name: arXiv
Year: 2014
Subjects: subject: History and Philosophy of Physics (physics.hist-ph)
subject: FOS: Physical sciences

description: I discuss three connections between Dummett's writings about time and philosophical aspects of physics. The first connection (Section 2) arises from remarks of Dummett's about the different relations of observation to time and to space. The main point is uncontroversial and applies equally to classical and quantum physics. It concerns the fact that perceptual processing is so rapid, compared with the typical time-scale on which macroscopic objects change their observable properties, that it engenders the idea of a 'common now', spread across space. The other two connections are specific to quantum theory, as interpreted along the lines of Everett. So for these two connections, the physics side is controversial, just as the philosophical side is. In Section 3, I connect the subjective uncertainty before an Everettian 'splitting' of the multiverse to Dummett's suggestion, inspired by McTaggart, that a complete, i.e. indexical-free description of a temporal reality is impossible. And in Section 4, I connect Barbour's denial that time is real---a denial along the lines of Everett, rather than McTaggart---to Dummett's suggestion that statements about the past are not determinately true or false, because they are not effectively decidable.
description: 25 pages; no figures
Development of a fluorescence-based assay to screen antiviral drugs against Kaposi's sarcoma associated herpesvirus
Creators: name: Case, R. J.
name: Oberlies, N. H.
name: Hilscher, C.
name: Nun, T. K.
name: Wang, L.
name: Soejarto, D. D.
name: Gao, S.-J.
name: Damania, B.
name: Kroll, D. J.
name: Piskaut, P.
name: Matainaho, T.
name: Dittmer, D. P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Tumors associated with Kaposi's sarcoma–associated herpesvirus infection include Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. Virtually all of the tumor cells in these cancers are latently infected and dependent on the virus for survival. Latent viral proteins maintain the viral genome and are required for tumorigenesis. Current prevention and treatment strategies are limited because they fail to specifically target the latent form of the virus, which can persist for the lifetime of the host. Thus, targeting latent viral proteins may prove to be an important therapeutic modality for existing tumors as well as in tumor prevention by reducing latent virus load. Here, we describe a novel fluorescence-based screening assay to monitor the maintenance of the Kaposi's sarcoma–associated herpesvirus genome in B lymphocyte cell lines and to identify compounds that induce its loss, resulting in tumor cell death.
INSPIRE: INvestigating Stellar Population In RElics III. Second data release (DR2): testing the systematics on the stellar velocity dispersion
Creators: name: D'Ago, G.
name: Spiniello, C.
name: Coccato, L.
name: Tortora, C.
name: La Barbera, F.
name: Arnaboldi, M.
name: Bevacqua, D.
name: Ferré-Mateu, A.
name: Gallazzi, A.
name: Hartke, J.
name: Hunt, L. K.
name: Martín-Navarro, I.
name: Napolitano, N. R.
name: Pulsoni, C.
name: Radovich, M.
name: Saracco, P.
name: Scognamiglio, D.
name: Zibetti, S.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: This is the second data release (DR2) of the INvestigating Stellar Population In RElics (INSPIRE) project, comprising 21 new systems with observations completed before March 2022. For each system, we release four one-dimensional (1D) spectra to the ESO Science Archive, one spectrum for each arm of the X-Shooter spectrograph. In this paper, we focus on the line-of-sight velocity distribution, measuring integrated stellar velocity dispersions from the spectra, and assessing their robustness and the associated uncertainties. For each of the 21 new systems, we systematically investigated the effect of the parameters and set-ups of the full spectral fitting on the stellar velocity dispersion ($σ$) measurements. In particular, we tested how $σ$ changes when several parameters of the fit as well as the resolution and spectral coverage of the input spectra are varied. We found that the effect that causes the largest systematic uncertainties on $σ$ is the wavelength range used for the fit, especially for spectra with a lower signal-to-noise ratio (S/N $\leq$ 30). When using blue wavelengths (UVB arm) one generally underestimates the velocity dispersion (by $\sim$15 km/s). The values obtained from the near-IR (NIR) arm present a larger scatter because the quality of the spectra is lower. We finally compared our results with those in literature, finding a very good agreement overall. Joining results obtained in DR1 with those presented here, INSPIRE contains 40 ultra-compact massive galaxies, corresponding to 75% of the whole survey. By plotting these systems in a stellar mass-velocity dispersion diagram, we identify at least four highly reliable relic candidates among the new systems. Their velocity dispersion is larger than that of normal-sized galaxies of similar stellar mass.
description: Accepted for publication, and in press on A&A
MY Camelopardalis, a very massive merger progenitor
Creators: name: Lorenzo, J.
name: Negueruela, I.
name: Baker, A. K. F. Val
name: García, M.
name: Simón-Díaz, S.
name: Pastor, P.
name: Majuelos, M. Méndez
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Context. The early-type binary MY Cam belongs to the young open cluster Alicante 1, embedded in Cam OB3. Aims. MY Cam consists of two early-O type main-sequence stars and shows a photometric modulation suggesting an orbital period slightly above one day. We intend to confirm this orbital period and derive orbital and stellar parameters. Methods. Timing analysis of a very exhaustive (4607 points) light curve indicates a period of 1.1754514 +- 0.0000015 d. High- resolution spectra and the cross-correlation technique implemented in the TODCOR program were used to derive radial velocities and obtain the corresponding radial velocity curves for MY Cam. Modelling with the stellar atmosphere code FASTWIND was used to obtain stellar parameters and create templates for cross-correlation. Stellar and orbital parameters were derived using the Wilson-Devinney code, such that a complete solution to the binary system could be described. Results. The determined masses of the primary and secondary stars in MY Cam are 37.7 +- 1.6 and 31.6 +- 1.4 Msol, respectively. The corresponding temperatures, derived from the model atmosphere fit, are 42 000 and 39 000 K, with the more massive component being hotter. Both stars are overfilling their Roche lobes, sharing a common envelope. Conclusions. MY Cam contains the most massive dwarf O-type stars found so far in an eclipsing binary. Both components are still on the main sequence, and probably not far from the zero-age main sequence. The system is a likely merger progenitor, owing to its very short period.
description: 8 pages, 6 figures, photometric data available on-line, Astronomy and Astrophysics, 2014
Friction forces in cosmological models
Creators: name: Bini, Donato
name: Geralico, Andrea
name: Gregoris, Daniele
name: Succi, Sauro
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We investigate the dynamics of test particles undergoing friction forces in a Friedmann-Robertson-Walker (FRW) spacetime. The interaction with the background fluid is modeled by introducing a Poynting-Robertson-like friction force in the equations of motion, leading to measurable (at least in principle) deviations of the particle trajectories from geodesic motion. The effect on the peculiar velocities of the particles is investigated for various equations of state of the background fluid and different standard cosmological models. The friction force is found to have major effects on particle motion in closed FRW universes, where it turns the time-asymptotic value (approaching the recollapse) of the peculiar particle velocity from ultra-relativistic (close to light speed) to a co-moving one, i.e., zero peculiar speed. On the other hand, for open or flat universes the effect of the friction is not so significant, because the time-asymptotic peculiar particle speed is largely non-relativistic also in the geodesic case.
description: 8 pages, 2 figures; published version
Active roles for inhibitory  B kinases   and   in nuclear factor- B-mediated chemoresistance to doxorubicin
Creators: name: Bednarski, B. K.
name: Kim, H. J.
name: Ding, X.
name: Baldwin, A. S.
name: Coombe, K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Chemotherapy agents have been shown to induce the transcription factor NF-κB and subsequent chemoresistance in fibrosarcomas and other cancers. The mechanism of NF-κB-mediated chemoresistance remains unclear, with a previous report suggesting that doxorubicin induces this response independent of the inhibitory κB kinases (IKKs). Other studies have indicated that IKKβ, but not IKKα, is required. Mouse embryo fibroblasts (MEF) devoid of IKKα, IKKβ, or both subunits (DKO) were treated with doxorubicin. The absence of either IKKα or IKKβ or both kinases resulted in impaired induction of NF-κB DNA-binding activity in response to doxorubicin. To provide a valid clinical correlate, HT1080 human fibrosarcoma cells were transfected with small interference RNAs (siRNAs) specific for IKKα or IKKβ and then subsequently treated with doxorubicin. Knockdown of IKKα severely impaired the ability of doxorubicin to initiate NF-κB DNA-binding activity. However, a decrease in either IKKα or IKKβ resulted in decreased phosphorylation of p65 in response to doxorubicin. The inhibition of doxorubicin-induced NF-κB activation by the knockdown of either catalytic subunit resulted in increased cleaved caspase 3 and cleaved PARP, and increased apoptosis when compared to doxorubicin alone. The results of this study validate current approaches aimed at NF-κB inhibition to improve clinical therapies. Moreover, we demonstrate that IKKα plays a critical role in NF-κB-mediated chemoresistance in response to doxorubicin and may serve as a potential target in combinational strategies to improve chemotherapeutic response.
Reprogramming epigenetic silencing: artificial transcription factors synergize with chromatin remodeling drugs to reactivate the tumor suppressor mammary serine protease inhibitor
Creators: name: Blancafort, P.
name: Sun, X.
name: Lizardi, P. M.
name: Beltran, A. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Mammary serine protease inhibitor (maspin) is an important tumor suppressor gene whose expression is associated not only with tumor growth inhibition but also with decreased angiogenesis and metastasis. Maspin expression is down-regulated in metastatic tumors by epigenetic mechanisms, including aberrant promoter hypermethylation. We have constructed artificial transcription factors (ATFs) as novel therapeutic effectors able to bind 18-bp sites in the maspin promoter and reactivate maspin expression in cell lines that harbor an epigenetically silenced promoter. In this article, we have investigated the influence of epigenetic modifications on ATF-mediated regulation of maspin by challenging MDA-MB-231 breast cancer cells, comprising a methylated maspin promoter, with different doses of ATFs and chromatin remodeling drugs: the methyltransferase inhibitor 5-aza-2′-deoxycytidine and the histone deacetylase inhibitor suberoylanilide hydroxamic acid. We found that the ATFs synergized with both inhibitors in reactivating endogenous maspin expression. The strongest synergy was observed with the triple treatment ATF-126 + 5-aza-2′-deoxycytidine + suberoylanilide hydroxamic acid, in which the tumor suppressor was reactivated by 600-fold. Furthermore, this combination inhibited tumor cell proliferation by 95%. Our data suggest that ATFs enhance the efficiency of chromatin remodeling drugs in reactivating silenced tumor suppressors. Our results document the power of a novel therapeutic approach that combines both epigenetic and genetic (sequence-specific ATFs) strategies to reactivate specifically silenced regions of the genome and reprogram cellular phenotypes.