Global Characterisation of Coagulopathy in Isolated Traumatic Brain Injury (iTBI): A CENTER-TBI Analysis
Creators: name: Böhm, Julia K
name: Güting, Helge
name: Thorn, Sophie
name: Schäfer, Nadine
name: Rambach, Victoria
name: Schöchl, Herbert
name: Grottke, Oliver
name: Rossaint, Rolf
name: Stanworth, Simon
name: Curry, Nicola
name: Lefering, Rolf
name: Maegele, Marc
name: Åkerlund, Cecilia
name: Amrein, Krisztina
name: Andelic, Nada
name: Andreassen, Lasse
name: Anke, Audny
name: Antoni, Anna
name: Audibert, Gérard
name: Azouvi, Philippe
name: Azzolini, Maria Luisa
name: Bartels, Ronald
name: Barzó, Pál
name: Beauvais, Romuald
name: Beer, Ronny
name: Bellander, Bo-Michael
name: Belli, Antonio
name: Benali, Habib
name: Berardino, Maurizio
name: Beretta, Luigi
name: Blaabjerg, Morten
name: Bragge, Peter
name: Brazinova, Alexandra
name: Brinck, Vibeke
name: Brooker, Joanne
name: Brorsson, Camilla
name: Buki, Andras
name: Bullinger, Monika
name: Cabeleira, Manuel
name: Caccioppola, Alessio
name: Calappi, Emiliana
name: Calvi, Maria Rosa
name: Cameron, Peter
name: Lozano, Guillermo Carbayo
name: Carbonara, Marco
name: Cavallo, Simona
name: Chevallard, Giorgio
name: Chieregato, Arturo
name: Citerio, Giuseppe
name: Ceyisakar, Iris
name: Clusmann, Hans
name: Coburn, Mark
name: Coles, Jonathan
name: Cooper, Jamie D
name: Correia, Marta
name: Čović, Amra
name: Czeiter, Endre
name: Czosnyka, Marek
name: Dahyot-Fizelier, Claire
name: Dark, Paul
name: Dawes, Helen
name: De Keyser, Véronique
name: Degos, Vincent
name: Corte, Francesco Della
name: Boogert, Hugo den
name: Depreitere, Bart
name: Đilvesi, Đula
name: Dixit, Abhishek
name: Donoghue, Emma
name: Dreier, Jens
name: Dulière, Guy-Loup
name: Ercole, Ari
name: Esser, Patrick
name: Ezer, Erzsébet
name: Fabricius, Martin
name: Feigin, Valery L
name: Foks, Kelly
name: Frisvold, Shirin
name: Furmanov, Alex
name: Gagliardo, Pablo
name: Galanaud, Damien
name: Gantner, Dashiell
name: Gao, Guoyi
name: George, Pradeep
name: Ghuysen, Alexandre
name: Giga, Lelde
name: Glocker, Ben
name: Golubovic, Jagoš
name: Gomez, Pedro A
name: Gratz, Johannes
name: Gravesteijn, Benjamin
name: Grossi, Francesca
name: Gruen, Russell L
name: Gupta, Deepak
name: Haagsma, Juanita A
name: Haitsma, Iain
name: Helbok, Raimund
name: Helseth, Eirik
name: Horton, Lindsay
name: Huijben, Jilske
name: Hutchinson, Peter J
name: Jacobs, Bram
name: Jankowski, Stefan
name: Jarrett, Mike
name: Jiang, Ji-yao
name: Johnson, Faye
name: Jones, Kelly
name: Karan, Mladen
name: Kolias, Angelos G
name: Kompanje, Erwin
name: Kondziella, Daniel
name: Koraropoulos, Evgenios
name: Koskinen, Lars-Owe
name: Kovács, Noémi
name: Kowark, Ana
name: Lagares, Alfonso
name: Lanyon, Linda
name: Laureys, Steven
name: Lecky, Fiona
name: Ledoux, Didier
name: Legrand, Valerie
name: Lejeune, Aurelie
name: Levi, Leon
name: Lightfoot, Roger
name: Lingsma, Hester
name: Maas, Andrew IR
name: Castaño-León, Ana M
name: Majdan, Marek
name: Manara, Alex
name: Manley, Geoffrey
name: Martino, Costanza
name: Maréchal, Hugues
name: Mattern, Julia
name: McMahon, Catherine
name: Melegh, Béla
name: Menon, David
name: Menovsky, Tomas
name: Mikolic, Ana
name: Misset, Benoit
name: Muraleedharan, Visakh
name: Murray, Lynnette
name: Negru, Ancuta
name: Nelson, David
name: Newcombe, Virginia
name: Nieboer, Daan
name: Nyirádi, József
name: Olubukola, Otesile
name: Oresic, Matej
name: Ortolano, Fabrizio
name: Palotie, Aarno
name: Parizel, Paul M
name: Payen, Jean-François
name: Perera, Natascha
name: Perlbarg, Vincent
name: Persona, Paolo
name: Peul, Wilco
name: Piippo-Karjalainen, Anna
name: Pirinen, Matti
name: Ples, Horia
name: Polinder, Suzanne
name: Pomposo, Inigo
name: Posti, Jussi P
name: Puybasset, Louis
name: Radoi, Andreea
name: Ragauskas, Arminas
name: Raj, Rahul
name: Rambadagalla, Malinka
name: Rhodes, Jonathan
name: Richardson, Sylvia
name: Richter, Sophie
name: Ripatti, Samuli
name: Rocka, Saulius
name: Roe, Cecilie
name: Roise, Olav
name: Rosand, Jonathan
name: Rosenfeld, Jeffrey V
name: Rosenlund, Christina
name: Rosenthal, Guy
name: Rossi, Sandra
name: Rueckert, Daniel
name: Rusnák, Martin
name: Sahuquillo, Juan
name: Sakowitz, Oliver
name: Sanchez-Porras, Renan
name: Sandor, Janos
name: Schmidt, Silke
name: Schoechl, Herbert
name: Schoonman, Guus
name: Schou, Rico Frederik
name: Schwendenwein, Elisabeth
name: Sewalt, Charlie
name: Skandsen, Toril
name: Smielewski, Peter
name: Sorinola, Abayomi
name: Stamatakis, Emmanuel
name: Stevens, Robert
name: Stewart, William
name: Steyerberg, Ewout W
name: Stocchetti, Nino
name: Sundström, Nina
name: Synnot, Anneliese
name: Takala, Riikka
name: Tamás, Viktória
name: Tamosuitis, Tomas
name: Taylor, Mark Steven
name: Ao, Braden Te
name: Tenovuo, Olli
name: Theadom, Alice
name: Thomas, Matt
name: Tibboel, Dick
name: Timmers, Marjolein
name: Tolias, Christos
name: Trapani, Tony
name: Tudora, Cristina Maria
name: Unterberg, Andreas
name: Vajkoczy, Peter
name: Vallance, Shirley
name: Valeinis, Egils
name: Vámos, Zoltán
name: van der Jagt, Mathieu
name: Van der Steen, Gregory
name: van der Naalt, Joukje
name: van Dijck, Jeroen TJM
name: van Essen, Thomas A
name: Van Hecke, Wim
name: van Heugten, Caroline
name: Van Praag, Dominique
name: Vyvere, Thijs Vande
name: van Wijk, Roel PJ
name: Vargiolu, Alessia
name: Vega, Emmanuel
name: Velt, Kimberley
name: Verheyden, Jan
name: Vespa, Paul M
name: Vik, Anne
name: Vilcinis, Rimantas
name: Volovici, Victor
name: von Steinbüchel, Nicole
name: Voormolen, Daphne
name: Vulekovic, Petar
name: Wang, Kevin KW
name: Wiegers, Eveline
name: Williams, Guy
name: Wilson, Lindsay
name: Winzeck, Stefan
name: Wolf, Stefan
name: Yang, Zhihui
name: Ylén, Peter
name: Younsi, Alexander
name: Zeiler, Frederick A
name: Zelinkova, Veronika
name: Ziverte, Agate
name: Zoerle, Tommaso
Publisher: name: La Trobe
Year: 2021
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences
classificationCode: 3209
subject: Neurosciences
subject: FOS: Clinical medicine
classificationCode: 4205
subject: Nursing
subject: FOS: Health sciences

description: Background: Trauma-induced coagulopathy in patients with traumatic brain injury (TBI) is associated with high rates of complications, unfavourable outcomes and mortality. The mechanism of the development of TBI-associated coagulopathy is poorly understood. Methods: This analysis, embedded in the prospective, multi-centred, observational Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study, aimed to characterise the coagulopathy of TBI. Emphasis was placed on the acute phase following TBI, primary on subgroups of patients with abnormal coagulation profile within 4 h of admission, and the impact of pre-injury anticoagulant and/or antiplatelet therapy. In order to minimise confounding factors, patients with isolated TBI (iTBI) (n = 598) were selected for this analysis. Results: Haemostatic disorders were observed in approximately 20% of iTBI patients. In a subgroup analysis, patients with pre-injury anticoagulant and/or antiplatelet therapy had a twice exacerbated coagulation profile as likely as those without premedication. This was in turn associated with increased rates of mortality and unfavourable outcome post-injury. A multivariate analysis of iTBI patients without pre-injury anticoagulant therapy identified several independent risk factors for coagulopathy which were present at hospital admission. Glasgow Coma Scale (GCS) less than or equal to 8, base excess (BE) less than or equal to − 6, hypothermia and hypotension increased risk significantly. Conclusion: Consideration of these factors enables early prediction and risk stratification of acute coagulopathy after TBI, thus guiding clinical management.