cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Interobserver delineation uncertainty in involved-node radiation therapy (INRT) for early-stage Hodgkin lymphoma: on behalf of the Radiotherapy Committee of the EORTC lymphoma group
Creators: name: Aznar, Marianne C.
name: Girinsky, Theodore
name: Berthelsen, Anne Kiil
name: Aleman, Berthe
name: Beijert, Max
name: Hutchings, Martin
name: Lievens, Yolande
name: Meijnders, Paul
name: Petersen, Peter Meidahl
name: Schut, Deborah
name: Maraldo, Maja V.
name: Maazen, Richard Van Der
name: Specht, Lena
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Background and purpose: In early-stage classical Hodgkin lymphoma (HL) the target volume nowadays consists of the volume of the originally involved nodes. Delineation of this volume on a post-chemotherapy CT-scan is challenging. We report on the interobserver variability in target volume definition and its impact on resulting treatment plans. Materials and methods: Two representative cases were selected (1: male, stage IB, localization: left axilla; 2: female, stage IIB, localizations: mediastinum and bilateral neck). Eight experienced observers individually defined the clinical target volume (CTV) using involved-node radiotherapy (INRT) as defined by the EORTC-GELA guidelines for the H10 trial. A consensus contour was generated and the standard deviation computed. We investigated the overlap between observer and consensus contour [Sørensen-Dice coefficient (DSC)] and the magnitude of gross deviations between the surfaces of the observer and consensus contour (Hausdorff distance). 3D-conformal (3D-CRT) and intensity-modulated radiotherapy (IMRT) plans were calculated for each contour in order to investigate the impact of interobserver variability on each treatment modality. Similar target coverage was enforced for all plans. Results: The median CTV was 120 cm3 (IQR: 95–173 cm3) for Case 1, and 255 cm3 (IQR: 183–293 cm3) for Case 2. DSC values were generally high (>0.7), and Hausdorff distances were about 30 mm. The SDs between all observer contours, providing an estimate of the systematic error associated with delineation uncertainty, ranged from 1.9 to 3.8 mm (median: 3.2 mm). Variations in mean dose resulting from different observer contours were small and were not higher in IMRT plans than in 3D-CRT plans. Conclusions: We observed considerable differences in target volume delineation, but the systematic delineation uncertainty of around 3 mm is comparable to that reported in other tumour sites. This report is a first step towards calculating an evidence-based planning target volume margin for INRT in HL.
New insights into environmental factors influencing Parkinson’s disease
Creators: name: Fleury, Vanessa
Publisher: name: Université de Genève
Year: 2022
Subjects: info:eu-repo/classification/ddc/616.8
Parkinson's disease
Epidemiology
Air pollution
Oral microbiota

description:
Parkinson’s disease is a multisystem neurodegenerative disease with a vast heterogeneity in terms of clinical presentations and etiological factors. In a minority of cases (approximately 5% of patients) a clear genetic cause is involved. In most patients, the cause is unknown and probably implicates the cumulative result of numerous genetic and environmental insults and their interactions in the context of ageing. No curative treatment is currently available for Parkinson’s disease. Parkinson’s disease prevalence and incidence are growing worldwide and there is an urgent need to find curative if not modifying treatments.

Further studies are required to better clarify the etiology of Parkinson’s disease. Among them, epidemiological studies allow the identification of protective and harmful environmental contributors in order to provide arguments towards future interventions based upon modifiable risk factors. Basic science studies are also critical to better understand the specific mechanisms at work in Parkinson’s disease. Recently, a growing body of evidence has demonstrated the important role of gut microbiota in Parkinson’s disease.

We hereby describe a large cross-sectional population-based prevalence study as well as a retrospective incidence study that we undertook to ascertain for the first time in Switzerland the frequency of Parkinson’s disease and other types of degenerative and non-degenerative parkinsonism. This study provided an extensive overview of age-specific, sex-specific and age-adjusted prevalence and incidence of non-degenerative and degenerative forms of parkinsonism among which Parkinson’s disease is the most common cause. We then performed a subsequent study using an original approach coupling the geographic distribution of PD prevalent cases with spatial statistics. This study showed clusters of high Parkinson’s disease prevalence and supported a link between Parkinson’s disease and air pollution. The final study investigated the oral microbiota in Parkinson’s disease and we demonstrated that an oral dysbiosis (i.e. a disequilibrium in the oral commensal microbial community) is present in Parkinson’s disease.
Additional file 2: of The dual blockade of MET and VEGFR2 signaling demonstrates pronounced inhibition on tumor growth and metastasis of hepatocellular carcinoma
Creators: name: Zhang, Yu
name: Gao, Xiaomei
name: Zhu, Ying
name: Kadel, Dhruba
name: Sun, Haoran
name: Chen, Jing
name: Luo, Qin
name: Sun, Haoting
name: Yang, Luyu
name: Yang, Jing
name: Sheng, Yuanyuan
name: Zheng, Yan
name: Zhu, Kejin
name: Dong, Qiongzhu
name: Qin, Lunxiu
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Materials and Methods. (DOCX 30Â kb)
Understanding bacterial molecular weapons
Creators: name: Renzoni, Adriana Maria
Publisher: name: Université de Genève
Year: 2024
Subjects: info:eu-repo/classification/ddc/610

description:
Bacterial antibiotic resistance in different bacterial strains has been recognized for several decades as a world-wide problem. This is an alarming situation with still few alternatives to fight against. To face this problem, different aspects of antibiotic resistance have been considered such as identifying the bacterial molecular pathways leading to the development of resistance, identifying factors contributing to the spread of resistant bacteria, or finding alternatives for clinical treatment and clinical diagnostics. This Privat–Docent thesis compiles the efforts of my research programme that contributes to this world-wide problem. The never-ending history of bacterial antibiotic resistance is the result of its incredible capacity to continuously react and adapt to antibiotic attack. Bacteria use different strategic defences based on selection of gene resistant mutations or other mechanisms such as the unbelievable induction of their own metabolic dormancy. By applying several basic or innovative molecular techniques, such as nEMOTE, whole genome sequencing, ribosome profiling, RNA-seq, transmission and fluorescence microscopy techniques, we discovered a novel arsenal of weapons probably used in Staphylococcus aureus defence. We propose protein aggregation, degradation, and secretion systems, oxidative stress, cell-wall modification systems or even modulation of endoribonucleolytic enzymes or ribosome hibernation, as incredible defence weapons used by S. aureus to avoid antibiotic attack. Our scientific contribution allows us to propose new diagnostic tools and open several pathways for the discovery of new therapeutic targets.
Additional file 2: of Use of integrated imaging and serum biomarker profiles to identify subclinical dysfunction in pediatric cancer patients treated with anthracyclines
Creators: name: Toro-Salazar, Olga
name: Lee, Ji
name: Zellars, Kia
name: Perreault, Paige
name: Mason, Kathryn
name: Wang, Zhu
name: Hor, Kan
name: Gillan, Eileen
name: Zeiss, Caroline
name: Gatti, Daniel
name: Davey, Brooke
name: Kutty, Shelby
name: Liang, Bruce
name: Spinale, Francis
Publisher: name: figshare
Year: 2018
Subjects: Biochemistry
Space Science
Medicine
Cell Biology
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Developmental Biology
Hematology

description: Table S1. Plasma analytes assessed in referent normal subjects and in patients undergoing anthracycline therapy. Table S2. Linear regression of biomarkers at V1 to changes in Ejection Fraction >â 10% from V1 to V6). (PDF 186 kb)
A new resin glycoside from Calystegia soldanella and its antiviral activity towards herpes
Creators: name: Masateru Ono
name: Kanemaru, Yukiyo
name: Yasuda, Shin
name: Okawa, Masafumi
name: Junei Kinjo
name: Miyashita, Hiroyuki
name: Yokomizo, Kazumi
name: Yoshimitsu, Hitoshi
name: Nohara, Toshihiro
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: A new resin glycoside, named calysolin XVIII (1), was isolated from the leaves, stems and roots of Calystegia soldanella Roem. et Schult. (Convolvulaceae). The structure of 1 was defined as 11S-jalapinolic acid 11-O-β-d-glucopyranosyl-(1 → 3)-O-(2-O-2S-methylbutyryl,4-O-3-hydroxy-2-methylenebutyryl)-α-l-rhamnopyranosyl-(1 → 2)-[O-β-d-glucopyranosyl-(1 → 6)-O-(34-di-O-2S-methylbutyryl)-β-d-glucopyranosyl-(1 → 3)]-O-β-d-glucopyranosyl-(1 → 2)-β-d-quinovopyranoside, intramolecular 1,2″′″′-ester on the basis of spectroscopic data. Compound 1 is the first known resin glycoside to feature 3-hydroxy-2-methylenebutyric acid as a component organic acid. In addition, 1 demonstrated an antiviral activity against herpes simplex virus type 1, with an IC50 value 2.3 μM.
Coercion in psychiatric care: challenges and perspectives
Creators: name: Wullschleger, Alexandre
Publisher: name: Université de Genève
Year: 2024
Subjects: info:eu-repo/classification/ddc/616.89
Coercion
Inpatient psychiatry
Seclusion
Restraint
Human rights

description: The issue of coercion has been one of the major challenges in psychiatry since its earliest days. Coercion is a complex phenomenon, encompassing a wide range of practices, all of which have in common that they conflict with patients’ autonomy. There are different dimensions to restraint, which need to be considered within a global model. It is therefore possible to distinguish at least three central dimensions: coercive measures in the strict sense of the term, which include measures restricting freedom of movement and involuntary pharmacological treatment; informal coercion, which consists of the use of pressures and incentives to make patients accept therapeutic proposals; and subjective or perceived coercion, which encompasses all coercive experiences of patients in the psychiatric system. This thesis is structured around five original articles on three areas related to coercive measures: the negative consequences of coercion, risk factors for coercive measures, and interventions to reduce their use and consequences. The first article looks at the effects of coercion on the severity of psychiatric symptoms during hospitalisation, showing that the use of coercive measures is likely to worsen patients' mental state. The second and third articles are devoted to the study of risk factors for coercive measures in general adult psychiatric populations admitted via emergency departments, and in psycho-geriatric populations. Regarding emergency admissions, the results show that police intervention, aggressive behaviour and involuntary admission are all risk factors for the occurrence of coercive measures during hospitalisation. These measures mainly take place during the first 24 hours following admission. As for the elderly population, the study shows the determining role of cognitive disorders and associated aggressive behaviour in the use of coercive measures. Finally, the fourth and fifth articles present the results of a randomised clinical trial studying the effects of a debriefing intervention for coercive measures. They show that this intervention is effective in limiting the onset of post-traumatic stress symptoms and the level of perceived coercion. Future research should focus on better defining informal coercive practices, studying the effects of new models of hospital care on the use of coercive measures, and finally on the use of coercion in outpatient setting, as well as in other areas of medicine.
Additional file 3: of The dual blockade of MET and VEGFR2 signaling demonstrates pronounced inhibition on tumor growth and metastasis of hepatocellular carcinoma
Creators: name: Zhang, Yu
name: Gao, Xiaomei
name: Zhu, Ying
name: Kadel, Dhruba
name: Sun, Haoran
name: Chen, Jing
name: Luo, Qin
name: Sun, Haoting
name: Yang, Luyu
name: Yang, Jing
name: Sheng, Yuanyuan
name: Zheng, Yan
name: Zhu, Kejin
name: Dong, Qiongzhu
name: Qin, Lunxiu
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Astronomical and Space Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Figure S1. The E-cadherin, vimentin, CD34, HIF-1α, P-MET and total-MET expression levels in hepa1–6 orthotopic tumors after treatment with vehicle and VEGF antibody. Figure S2. The expression levels of E-cadherin, N-cadherin and vimentin were detected by Western blot in HCC cells starved overnight and treated with HGF (10 ng/ml) for 24 h. Figure S3. After 2-week treatment with VEGF antibody, PF-04217903 alone, and their combination, the mice were killed and the liver tissues were obtained. Figure S4. The E-cadherin, vimentin, CD34, HIF-1α, total-MET and P-MET expression levels in hepa1–6 orthotopic tumors after treatment with VEGF antibody and PF-04217903 alone, or their combination. Figure S5. The effect of NZ001 on VEGFR2 and MET signaling in HUVECs and HCC cells. Figure S6. NZ001 suppressed the HGF-induced EMT in HCC cells. Figure S7. Effects of NZ001 on the spontaneous and chemokine-induced invasion of HCC cell under normoxia and hypoxia condition. Figure S8. After 2-week treatment with sorafenib and NZ001, the mice were killed and the liver tissues were obtained. Figure S9. The total-MET, HIF-1α, CD34 and P-MET expression levels in hepa1–6 orthotopic tumors after treatment with VEGF antibody and PF-04217903 alone, or their combination. Figure S10. Effects of NZ001 on the metastasis of MHCC97H in nude mice. Figure S11. Effects of NZ001 on colony-formation of HCC cells. Figure S12. The association of MET exon 14 mutation determined by sanger sequencing with NZ001 sensitivity of 12 HCC cell lines. Figure S13. The score of MET and P-MET definition for IHC staining. Figure S14. The MET/P-MET/HGF expression in HCC cell lines. Figure S15. After 2-week treatment with different concentrations of NZ001, the mice were sacrificed and the tumors were obtained. Figure S16. IHC assay showed that MET phosphorylation was greatly inhibited after NZ001 treatment in MHCC-97H xenograft tumors. (DOCX 5327 kb)
Optimization of respiratory assistance through work of breathing and respiratory neuromuscular activitiy analysis in neonatal and pediatric patients: from bench to bedside
Creators: name: Bordessoule, Alice-Charlotte
Publisher: name: Université de Genève
Year: 2024
Subjects: info:eu-repo/classification/ddc/618

description:
Invasive and non invasive ventilatory support is a life-saving therapy in the Neonatal Intensive Care Unit (NICU) and Pediatric Intensive Care Unit (PICU). The management of mechanical ventilation remains a challenge due to a complex relationship between the ventilatory support and the patient.

As a preamble, we will explore the specificities of pediatric and neonatal respiratroy physiology in order to better understand the challenges of mechanical ventilation in this population, while focusing on the importance of patient's work of breathing. Our particular interest will be on the electrical activity of the diaphragm, after presenting all the main tools that can be used for this monitoring.

Our research work begins with a bench test, which aims to answer the question of whether the imposed work of breathing is influenced by the type of device and settings. We will then focus on the electrical activity of the diaphragm, which serves as an indirect indicator of the work of breathing, to determine if one of the three commonly used flow-variable CPAP in neonatalogy is superior to the others. Furthermore, we will explore how the diaphragmatic signal can also be useful in optimizing the respiratory assistance when used as a trigger for proportional respiratory support in a specific mode (Neurally Adjuted Ventilatory Assist), in terms of patient-ventilator interaction and respiratory variability maintenance. We will also present examples of clinical cases where the monitoring of electrical activity of the diaphragm, as well as transcutaneous electromyography (tc-EMG) of the respiratory muscles, help to optimize ventilatory management in clinical practice.

Finally, we will discuss future perspectives as we will 1) evaluate the correlation between diaphragmatic trans-cutaneous and trans-esophageal EMG, aiming to find a less invasive tool for the WOB’s monitoring in these patients, 2) explore patient-ventilator interactions in patients with acute respiratory failure associated to acute bronchiolitis, in order to optimize respiratory assistance, by comparing two types of support: NIV-NAVA and BIPAP with turbine driven ventilator. Lastly, for the quality improvement, we will implement a simulation program in our PICU to share knowledge of mechanical ventilation to the healthcare team.
title: Biomineralization processes in low-temperature, shallow-water hydrothermal vent at Tagoro submarine volcano, El Hierro Island (Central East Atlantic)
Creators: name:  Rincón-Tomás ,   Blanca
name:  González ,   Francisco Javier
name:  Somoza ,   Luis
name:  Hein ,   James R.
name:  Medialdea ,   Teresa
name:  Santofimia,   Esther
name:  Marino,   Egidio
name:  Madureira ,   Pedro
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: A novel hydrothermal system was discovered at the summit of the underwater Tagoro volcano at 89–120 m depth after the 2011–2012 eruption, characterized by the low-temperature venting of Fe-rich fluids that produced a seafloor draped by extensive Fe-flocculate deposits. The basanite-hornitos are capped by mm- to cm-thick hydrothermally derived Fe-oxyhydroxide sediment and contain micro-cracks and degasification vesicles filled by sulfides (mostly pyrite) and covered by sulfur-oxidizing bacterial mats. Electron microprobe studies on Fe-oxyhydroxide crusts show the presence of various organomineral structures, mainly twisted stalks and sheaths covered by iron-silica deposits, reflecting microbial iron-oxidation from the hydrothermal fluids. Sequencing of 16S rRNA genes also reveals the presence of other microorganisms involved in sulfur and methane cycles. Samples collected from hornito chimneys contain silicified microorganisms coated by Fe-rich precipitates. The rapid silicification may have been indirectly promoted by microorganisms acting as nucleation sites. We suggest that this type of hydrothermal deposits might be more frequent than presently reported to occur in submarine volcanoes. The discovery of this mineralization system and associated microbiota identifies a potential Fe-based chemosynthetic ecosystem, which typically have been studied at spreading centers and arc volcanoes. This underscores the importance of geomicrobiological interactions in shaping mineral deposits on Earth today, and in the geological past. This hydrothermal system provides an excellent laboratory to study the formation and evolution of newly formed hydrothermal deposits and their association with microbiota at an intraplate hot-spot volcanic edifice under low-temperature, shallow-water conditions.
Mindfulness in psychiatry: implementation, scientific evidence and challenges
Creators: name: Jermann, Françoise
Publisher: name: Université de Genève
Year: 2024
Subjects: info:eu-repo/classification/ddc/616.89
Mindfulness
Evidence-based medicine
Psychiatry

description: In contrast to mind-wandering, which is an automatic process, mindfulness means voluntarily paying attention to what is present (inside and outside oneself) and with a particular attitude, without judgment. Mindfulness-Based Stress Reduction (MBSR) was introduced into medicine in the late seventies and Mindfulness-Based Intervention (MBI) into psychiatry in the late nineties. The development of Mindfulness-Based Cognitive Therapy (MBCT) for the prevention of depressive relapse has been decisive from both a clinical and scientific point of view. Numerous randomized controlled trials (RCTs) have validated the efficacy of this intervention. MBCT halves the rate of depressive relapse compared with treatment as usual and is non-inferior to interventions such as continuing to take an antidepressant. In addition to efficacy studies, both quantitative and qualitative studies are favorable to MBCT. After MBCT for the prevention of depressive relapse, MBIs have been extended to other psychiatric disorders. Bipolar disorder and Attention-Deficit/Hyperactivity Disorder (ADHD) are good examples. For bipolar disorder, it was first necessary to verify feasibility, as this disorder was systematically excluded from MBCT studies, and then to set up efficacy studies. For ADHD, two approaches were developed in parallel: one developed a new MBI and the other adapted the MBCT protocol to ADHD. For both disorders, the first RCT studies are underway. Whether it's MBCT for the prevention of depressive relapses, MBCT for bipolar disorder, or MBI for ADHD, the question of the mechanisms of action is still open, and further studies are needed. To conclude, we can say that 20-30 years ago, people who took an interest in mindfulness were seen as a bit 'eccentric', but nowadays scientific evidence clearly shows that mindfulness has a place in the field of medicine.
Implementation science and research are key to improve diabetes self-management education and support interventions
Creators: name: Gastaldi, Giacomo Gianni Giuseppe
Publisher: name: Université de Genève
Year: 2024
Subjects: info:eu-repo/classification/ddc/616
Type 1 diabetes
Diabetes self-management
Implementation
Group-based diabetes self-management interventions

description:
Type 1 diabetes (T1D) is a serious auto-immune disease with a global prevalence of 5-7%, affecting around 9 million people in the occidental world in 2021. Living with diabetes is a complex task that requires the acquisition of many skills, appropriate self-care and psychological support. Appropriate Diabetes Self-Management (DSM) is a complex task to sustain and a minority of PwT1D remains free of T1D related complications.

Structured DSM education and support (DSMES) interventions have demonstrated strong benefits for PwT1D that include improvement in 1) general knowledges 2) know-how about insulin and technology use 3) quality of life 4) self-care 5) emotion regulation and 6) problem solving. Most importantly, participation to DSMES programs is associated with improved clinical and biological outcomes and a decreased morbidity, however less than 10% of PwT1D attend a structure DSMES program and their implementation remains insufficient.

The RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) framework including the evolution to Pragmatic Robust Implementation and Sustainability Model (PRISM) are effective to address multi-levels contexts like reduced availability and access to DSMES programs for T1D.

The aim of this present narrative review is to analyze the literature about existing validated DSMES interventions and programs for adult PwT1D using the RE-AIM framework and develop an implementation guidance in order to assess existing issues (dissemination and accessibility) and the potential of digital DSMES programs.

The literature confirms that structured group-based DSME programs combined with appropriate use of diabetes and technology, are effective in reducing HbA1c level, the frequency and severity of hypoglycemia, and diabetes related distress. There are few programs available, and only a few countries have managed to implement structured DSMES programs on a national scale. The curriculum is somewhat outdated and need to better integrate recent advances in technology, such as automated insulin delivery systems. Learning theories need to take into account the existence of a bidirectional interplay between affective states and cognitive skills.

Given the numerous and multifaceted barriers to implement DSMES programs in routine care, their digitalization seems very appealing to promote their access and attendance. The use of the RE-AIM + PRISM frameworks is relevant to develop a guidance addressing issues related to the implementation of DSMES programs, regardless of the mode of delivery (digital or in person). Further research in science implementation is needed to confirm the potential of digital DSMES programs.
Plan de Gestión de Datos de Investigación Empírica en Educación: Una experiencia desde un grupo consolidado
Creators: name: Rodríguez-Conde, María-José
Publisher: name: Zenodo
Year: 2025
Subjects: Ciencia abierta,
Gestión de datos
investigación educativa

description: Conferencia dentro de la Jornada de Transferencia ALFADATAUniv (Grupo de INvestigación INFORAL, Proyecto I+D) del 28 de febrero de 2025. Se impartió dentro de la mesa redonda sobre Alfabetización de datos en Ciencias Socailes: desafíos y oportunidades, compartiendo conferencia con Mercé Crosas (Directora del Centro Nacional de Supercomputación y Presidenta de CODATA), que trató sobre "AI-Ready Data for Social Sciences and Humanities, y con Socia Santiago Román (Coordiandora de los servicios bibliotecarios de la investigación de la USAL), con la conferencia sobre la gestión de datos de investigación en el contexto de ciencia abierta.
Innovating the treatment of acute ischemic stroke: translational research in neurointervention
Creators: name: Bernava, Gianmarco
Publisher: name: Université de Genève
Year: 2024
Subjects: info:eu-repo/classification/ddc/616.0757
Stroke
Thrombectomy
Thromboaspiration

description:
Acute ischemic stroke (AIS) is the second leading cause of mortality and the third leading cause of disability worldwide1. AIS is determined by the interruption of arterial blood flow to one or more regions of the brain parenchyma causing death of neural cells. The more time that elapses between the time of artery occlusion and revascularization by thrombus removal, the more neurons will die and thus the more severe the ultimate neurological deficit will be for the patient.

The goal of treatment is to remove the thrombus occluding the artery in order to reperfuse the brain tissue as quickly as possible. Mechanical thrombectomy (MT) consists of the mechanical removal of the thrombus using a stentriever (SR) or aspiration catheters. Although these techniques allow recanalization of the vessel in most cases2, in approximately 11-29%3 of patients the thrombus cannot be removed and the artery remains occluded. First-pass recanalization of the artery has been found to positively influence patient outcome at 3 months after treatment. However, first-pass recanalization is achieved in less than 25% of cases4 and more than one passage is often required to remove the thrombus. The success of MT depends on several factors such as the vascular anatomy, thrombus consistency and size, thrombus location, and the interaction between the thrombus and MT devices. In clinical practice, the neurointerventionalist is not aware of the characteristics of the thrombus or its precise location and cannot predict what interaction it will have with MT devices. Therefore, it is not always possible to explain the reasons why MT was unable to remove the thrombus.

This Privat Docent thesis represents the results of the author's research, which focused on trying to understand the reasons for the success or failure of different MT techniques in thrombus removal. This research was accomplished through both the analysis of clinical data and thrombectomy procedures and in vitro studies.
«Spielst du noch oder lernst du schon». Das Spiel im Kindergarten und sein Nutzen für einen optimalen Start in die erste Regelklasse
Creators: name: Walser, Bettina
Publisher: name: Interkantonale Hochschule für Heilpädagogik
Year: 2024
Subjects: Sonderpädagogik
Masterarbeit
Spiel
Lernen
Kindergarten
Nutzen
Schulstart
Regelklasse

description: Im Kindergarten hat das Spiel eine lange Tradition und wird als wichtiger Bestandteil der frühkindlichen Bildung betrachtet. Diese Masterarbeit untersucht, wie das Spiel im Kindergarten, die individuellen Lernvoraussetzungen gemäss dem INVO-Modell (Hasselhorn & Gold, 2022) für einen erfolgreichen Start in die erste Regelklasse unterstützt. Im Rahmen einer qualitativen Inhaltsanalyse werden spezifische Aspekte des Spiels und des Lernens untersucht. Im ersten Teil wird der Fokus auf theoretische Grundlagen der Spielpädagogik, der verschiedenen Spielformen und deren Einfluss auf die entwicklungspsychologischen Aspekte des Kindes gelegt. Zudem werden die individuellen Lernvoraussetzungen für ein erfolgreiches Lernen im Kindergartenspiel untersucht. Im zweiten Teil werden Ableitungen für die Kindergartenstufe gemacht und Schlussfolgerungen für die Praxis gezogen. Es werden Leitgedanken für das Spiel und das Lernen auf der Kindergartenstufe für einen gelingenden Start in die Regelklasse definiert.
Presence of Epstein–Barr virus-infected B lymphocytes with thyrotropin receptor antibodies on their surface in Graves’ disease patients and in healthy individuals
Creators: name: Nagata, Keiko
name: Higaki, Katsumi
name: Nakayama, Yuji
name: Miyauchi, Hiromi
name: Kiritani, Yui
name: Kanai, Kyosuke
name: Matsushita, Michiko
name: Iwasaki, Takeshi
name: Sugihara, Hirotsugu
name: Kuwamoto, Satoshi
name: Kato, Masako
name: Murakami, Ichiro
name: Nanba, Eiji
name: Kimura, Hiroshi
name: Hayashi, Kazuhiko
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Marine Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Graves’ disease is an autoimmune hyperthyroidism caused by thyrotropin receptor antibodies (TRAbs). Because Epstein–Barr virus (EBV) persists in B cells and is occasionally reactivated, we hypothesized that EBV contributes to TRAbs production in Graves’ disease patients by stimulating the TRAbs-producing B cells. In order for EBV to stimulate antibody-producing cells, EBV must be present in those cells but that have not yet been observed. We examined whether EBV-infected (EBV(+)) B cells with TRAbs on their surface (TRAbs(+)) as membrane immunoglobulin were present in peripheral blood of Graves’ disease patients. We analyzed cultured or non-cultured peripheral blood mononuclear cells (PBMCs) from 13 patients and 11 healthy controls by flow-cytometry and confocal laser microscopy, and confirmed all cultured PBMCs from 8 patients really had TRAbs(+) EBV(+) double positive cells. We unexpectedly detected TRAbs(+) cells in all healthy controls, and TRAbs(+) EBV(+) double positive cells in all cultured PBMC from eight healthy controls. The frequency of TRAbs(+) cells in cultured PBMCs was significantly higher in patients than in controls (p = 0.021). In this study, we indicated the presence of EBV-infected B lymphocytes with TRAbs on their surface, a possible player of the production of excessive TRAbs, the causative autoantibody for Graves’ disease. This is a basic evidence for our hypothesis that EBV contributes to TRAbs production in Graves’ disease patients. Our results further suggest that healthy controls have the potential for TRAbs production. This gives us an important insight into the pathogenesis of Graves’ disease.
From arterial stiffness to mathematical modelling: Clinical applications in the era of individualized medicine
Creators: name: Adamopoulos, Dionysios
Publisher: name: Université de Genève
Year: 2024
Subjects: info:eu-repo/classification/ddc/616
Arterial stiffness
Hemodynamics
Arterial pressure
Cardiac output

description: The elasticity of the arteries is determined by the histological composition of the arterial wall and plays a central role in in regulating globally the cardiovascular function. The stiffening of the arteries is a physiological, age-related process, with detrimental though effects on the central and peripheral hemodynamics. It is known that the arterial stiffening may be accelerated in the presence of various mechanical, oxidative or metabolic stress factors. Specifically, the exposure to tobacco smoke (active or passive) promotes arterial stiffness, enhances wave reflections to the aorta and provokes microvascular endothelial dysfunction, explaining (at least partially) the association between smoking and cardiovascular events. Among other toxic substances contained in tobacco, nicotine plays a pivotal role in the smoke induced vascular dysfunction by affecting both arterial stiffness and the central hemodynamics. Due to its central role in modulating the cardiovascular function, arterial stiffness (and its hemodynamic consequences) has a significant, independent role in predicting cardiovascular events. This has been demonstrated in different groups including patients with essential arterial hypertension, coronary artery disease, end-stage renal disease, aortic valve stenosis and in the general population. The combination of arterial stiffness with geometrical and functional data of the cardiovascular system gave birth to detailed mathematical models, capable of describing blood propagation phenomena throughout the arterial tree. These models offer unique opportunities to study complex physiological interactions, such as the impact of different component of left ventricular afterload on the evaluation of aortic valve stenosis or the interplay between cardiac output and systemic pressure waveforms. Apart from elucidating complicated pathophysiological mechanisms, the use of these patientadjustable models offers comprehensive diagnostic and therapeutic solutions that can be easily integrated in the everyday clinical practice, paving the way for personalized treatment in the era of individualized medicine.
Improving patients’ outcomes in urology: the rise of the robots
Creators: name: Benamran, Daniel Alexandre Israel
Publisher: name: Université de Genève
Year: 2024
Subjects: info:eu-repo/classification/ddc/617

description:
Robot-assisted laparoscopic surgery has taken a significant place in modern urological therapeutic arsenal. This evolution has been made possible by rapid technological developments and the easy continuum from traditional laparoscopy to the robotic approach. As often in surgery, these technological advances have been adopted without waiting for the result of prospective randomized studies, but they have significantly transformed patient care to become a new standard.

The benefits of the robotic approach are found in various urological surgeries. Although the robotic approach might not be superior to an open or laparoscopic approach (particularly in terms of cost), its benefits are found in the reduction of postoperative hospital stays, the reduction of pain, and a faster return to an active life, which is constantly observed with minimally invasive surgery.

The aim of this thesis is to present some of our work highlighting these benefits for the management of urological patients. Whether for reconstructive surgery (ureteral anastomosis, pyeloplasty), functional surgery (simple prostatectomy, living donor nephrectomy), or oncological surgery (radical prostatectomy, partial nephrectomy), the articles compiled here highlight the feasibility and benefits of the robotic approach in different surgical indications, sometimes pushing the benefit of the minimally invasive approach to the point of transforming surgeries historically performed with a long hospital stay into outpatient surgeries. The perspectives of new developments in urological robotic surgery, such as same day discharge, single port or natural ports surgery will also be outlined, as well as cost-effectiveness of large adoption of the robotic approach to health care systems and challenges to produce high level evidence.
Cross-linking of lens crystallin proteins induced by tryptophan metabolites and metal ions: implications for cataract development
Creators: name: Tweeddale, Helen J.
name: Hawkins, Clare L.
name: Janmie, Joane F.
name: Truscott, Roger J. W.
name: Davies, Michael J.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Long-wavelength solar UV radiation is implicated in photodamage to the human eye. The human lens contains multiple tryptophan-derived compounds that have significant absorbance bands in the UVA region (λ 315–400 nm) that act as efficient physical filters for these wavelengths. The concentrations of many of these UV filter compounds decrease with increase in age, resulting in diminished protection, increased oxidative damage and the accumulation of modified proteins implicated in nuclear cataract formation. This damage may arise via the formation of α,β-unsaturated carbonyls from the UV filter compounds, adduction to lens proteins and subsequent action as photosensitizers, and/or via the reactions of redox-active transition metal ions that accumulate in aged human lenses. The latter may promote the oxidation of free, or protein-bound, o-aminophenols, such as the UV filter compounds 3-hydroxykynurenine (3OHKyn) and 3-hydroxyanthranilic acid (3OHAA). It is shown here that Cu(II), and to a lesser extent Fe(III), enhance oxidation of free 3OHKyn, 3OHAA and 3OHKyn bound to specific amino acids and lens proteins, with this resulting in increased cross-linking of lens proteins. These data indicate that elevated levels of transition metal ions in aging lenses can enhance the loss of protective UV filter compounds, and contribute to the formation of high-molecular-mass dysfunctional crystallin proteins in a light-independent manner. These reactions may contribute to the formation of lens cataracts in humans.
Additional file 1: of A novel small molecule inhibitor of MDM2-p53 (APG-115) enhances radiosensitivity of gastric adenocarcinoma
Creators: name: Yi, Hanjie
name: Yan, Xianglei
name: Luo, Qiuyun
name: Yuan, Luping
name: Li, Baoxia
name: Pan, Wentao
name: Zhang, Lin
name: Chen, Haibo
name: Wang, Jing
name: Zhang, Yubin
name: Zhai, Yifan
name: Qiu, Miao-Zhen
name: Yang, Da-Jun
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Mathematical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: The affinities to MDM2 of several MDM2-p53 compounds. (DOCX 16 kb)
title: Fracture network characterization and DFN modelling of the Upper Carboniferous, Ruhr Area, Germany
Creators: name:  Allgaier,   Felix
name:  Busch ,   Benjamin
name:  Quandt ,   Dennis
name:  Niederhuber ,   Thomas
name:  Müller ,   Birgit
name:  Hilgers ,   Christoph
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: Since coal mining in the Ruhr Area has been ceased, mine water drainage is gradually reduced leading to the rise of formation water and groundwater levels. Rising mine water levels increase the pore pressure and induce stress changes in the subsurface, which may reactivate natural and/or mining-related faults and fractures. As part of the interdisciplinary FloodRisk project, which aims to enhance the understanding of the geomechanical coupling of increased pore pressure and heterogeneous ground movements, we present a geological km-scale 3D model of a former mining area hosted in the Upper Carboniferous. Fault and horizon geometries are constructed based on coal seam mappings from the Geological Survey of NRW. Beside the integration of petrophysical data, a discrete fracture network model (DFN) is implemented to capture the fracture network of the subsurface. Therefore, Upper Carboniferous outcrops were studied by UAV-derived 3D outcrop models to analyse fracture parameters. Fracture network characterization revealed five dominant fracture sets with striking orientations of N-S, NE-SW, ENE-WSW, WNW-ESE and NW-SE. Calculated dilation tendencies provide information on which fracture sets are likely to contribute to fluid flow in the subsurface. A DFN model is stochastically modelled based on these “effective” fracture sets and will be the basis for the construction of a simulation model.
MOESM1 of Postprandial increase in serum CA125 as a surrogate biomarker for early diagnosis of ovarian cancer
Creators: name: Gu, Zhuowei
name: He, Yifeng
name: Zhang, Yue
name: Chen, Mo
name: Song, Keqi
name: Huang, Yuting
name: Li, Qing
name: Di, Wen
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Chemical Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Computational Biology

description: Additional file 1: Table S1â S5. Demographic, clinical and pathological characteristics of the study population. Serum CA125 levels (random) detected in the study population. Comparisons of the differences of CA125 serum levels (random) among the five disease groups. Comparisons of the differences between fasting and postprandial CA125 serum levels for the fiveÂ disease groups. Coordinates of the ROC curve for fasting CA125 levels (calculated by SPSS 18.0).
Impact of Internal In-Migration on Income Inequality in Receiving Areas: A District Level Study of South Africa
Creators: name: Umakrishnan Kollamparambil
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: The impact of internal migration on regional income inequality of the receiving areas has hitherto gone largely unstudied. This dearth of literature is especially surprising because income inequality and in-migration into urban centres of growth are two issues that many developing economies are faced with and tackling these issues effectively involves understanding the interactions between these two related phenomena. This study is therefore a first attempt to analyse the impact of internal in-migration on receiving areas and is placed in the context of South Africa. Based on a conceptual analysis, the study argues that in-migration into the formal sector of the receiving areas will in general reduce inequality while in-migration into the informal or unemployed sector increases inequality. Using individual panel data the study further tests empirically at the district level the impact of in-migration and finds that rising urban inequality in urban areas can be attributed at least in part to rural-urban migration. This works through both the wage as well as employment channel. The employment channel can be said to have a stronger impact than the wage channel as indicated by the coefficients estimated through our system GMM regression analysis.
Global population genomic signature of Spodoptera frugiperda (fall armyworm) supports complex introduction events across the Old World.
Creators: name: Tay, Wee Tek
name: Rane, Rahul V
name: Padovan, Amanda
name: Walsh, Tom K
name: Elfekih, Samia
name: Downes, Sharon
name: Nam, Kiwong
name: D'Alençon, Emmanuelle
name: Zhang, Jianpeng
name: Wu, Yidong
name: Nègre, Nicolas
name: Kunz, Daniele
name: Kriticos, Darren J
name: Czepak, Cecilia
name: Otim, Michael H
name: Gordon, Karl HJ
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Article
/631/158/2178
/631/181/2474
article

description: Funder: Cotton Research and Development Corporation (CRDC); doi: https://doi.org/10.13039/501100000977
description: Funder: Bayer | Bayer CropScience; doi: https://doi.org/10.13039/100008791
description: Native to the Americas, the invasive Spodoptera frugiperda (fall armyworm; FAW) was reported in West Africa in 2016, followed by its chronological detection across the Old World and the hypothesis of an eastward Asia expansion. We explored population genomic signatures of American and Old World FAW and identified 12 maternal mitochondrial DNA genome lineages across the invasive range. 870 high-quality nuclear single nucleotide polymorphic DNA markers identified five distinct New World population clusters, broadly reflecting FAW native geographical ranges and the absence of host-plant preferences. We identified unique admixed Old World populations, and admixed and non-admixed Asian FAW individuals, all of which suggested multiple introductions underpinning the pest's global spread. Directional gene flow from the East into eastern Africa was also detected, in contrast to the west-to-east spread hypothesis. Our study demonstrated the potential of population genomic approaches via international partnership to address global emerging pest threats and biosecurity challenges.