cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Favorinus mirabilis Baba 1955
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Facelinidae
Favorinus
Favorinus mirabilis

description: Favorinus mirabilis Baba, 1955
(Figure 35 A)
Material examined. Five specimens. MB28-004771, VIPP, 12 Aug. 2013, 18m, 6mm; MB28-0 0 4818, MB28- 0 0 4820, MB28-004822 and MHN-YT1182, POA, 0 7 May 2014, 15m, 3–11mm. Habitats. Subtropical rocky reefs and tropical coral reefs.
Occurrences. Ponta do Ouro and Vamizi Island.
Geographic distribution. Indo-west, central Pacific. Hawaii, French Polynesia, Marshall Islands, Guam (Gosliner et al. 2008), Japan (Baba 1955), Papua New Guinea, Philippines, Singapore, Comoros Islands, Tanzania (Gosliner et al. 2008) and Mozambique.
Remarks. All specimens were found on the spawn of Hexabranchus sanguineus.
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on pages 111-113, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Investigating the cell of origin for hepatocellular carcinoma
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Liver cancer is the third leading cause of cancer-related deaths worldwide. In the U.S., Hispanics, Asians and Black Americans are the most afflicted, all together representing 60% of the entire U.S. population with liver cancer. The burden of liver cancer falls heaviest on California, where the three ethnic groups constitute more than 50% of the state population. Tobacco is a risk factor for liver cancer. Studies show that smokers with liver conditions are more likely to develop liver cancer than non-smokers. Given that there were 34.1 million active smokers in the U.S. in 2019, liver cancer is a critical national health concern.

 To better diagnose and treat liver cancer, we need to understand the mechanism of liver cancer formation. Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the two most common types of liver cancers. These two cancers show different clinical features but share some similarities at molecular levels, including a common set of mutations. Studies in mice suggest that hepatocytes, which are recognized as the main cell of origin of HCC, may also give rise to ICC. However, this has not been validated in ICCs in patients.

 My primary research goal is to address this gap in knowledge by determining the mechanism of liver cancer initiation from hepatocytes. Our lab has recently succeeded in developing a humanized mouse model of liver cancer where mice develop tumors that represent ICCs from patients. Our humanized liver cancer mouse model is a first of its kind and it has potential to overcome the limitations found in conventional mouse model of liver cancer. Here, I will utilize our humanized mouse model to determine how hepatocytes give rise to ICCs in patients and derive a new humanized mouse model of HCC from our current humanized mouse model of ICC. I will achieve this by identifying the pathways that are important for ICC and modulating them in human hepatocytes by introducing mutations that are specifically found in HCCs in patients. I believe that the knowledge gained from this work will advance our understanding of liver cancer initiation and identify new targets for therapy.
Bathylasmatidae Newman & Ross 1971
Creators: name: Chan, Benny K. K.
name: Dreyer, Niklas
name: Gale, Andy S.
name: Glenner, Henrik
name: Ewers-Saucedo, Christine
name: Pérez-Losada, Marcos
name: Kolbasov, Gregory A.
name: Crandall, Keith A.
name: Høeg, Jens T.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Thecostraca
Balanomorpha
Bathylasmatidae

description: †FAMILY BATHYLASMATIDAE NEWMAN & ROSS, 1971 (PALAEOCENE–RECENT)
Diagnosis: Wall of six plates; parietes solid or tubiferous; when tubiferous, tubes uniformly arranged in single row; interlaminate figures simple; basis calcareous or membranous; when membranous, wall solid.
Comment: Jones (2000), based on morphology, classified Hexelasma Hoek, 1913 and Bathylasma Newman & Ross, 1971 under Pachylasmatoidea. Based on molecular evidence, Chan et al. (2017a) showed that the clade containing Hexelasma and Bathylasma is sister to Tetraclitidae in the same clade. This suggests that Bathylasmatidae should be treated as an individual family and included in Coronuloidea.
description: Published as part of Chan, Benny K. K., Dreyer, Niklas, Gale, Andy S., Glenner, Henrik, Ewers-Saucedo, Christine, Pérez-Losada, Marcos, Kolbasov, Gregory A., Crandall, Keith A. & Høeg, Jens T., 2021, The evolutionary diversity of barnacles, with an updated classification of fossil and living forms, pp. 789-846 in Zoological Journal of the Linnean Society 193 on page 835, DOI: 10.1093/zoolinnean/zlaa160, http://zenodo.org/record/5637275
Development of SSR markers in polyploid species using ddRAD sequence data: a case study in the genus Mimosa
Creators: name: CALDERón, Franco
name: Gilszlak, Jazmín V.
name: Gutiérrez, Ángela V.
name: Fortunato, Renée H.
name: Lía, Verónica V.
name: Morales, Matías
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: Mimosa L. is a megadiverse genus where lower rank classification is challenging due to widespread morphological similarities. M. subser. Obstrigosae includes 12 species with different ploidy levels. Morphological boundaries between them are defined by a few traits influenced by the environment. The extreme case is displayed by M. tandilensis and M. ramulosa which are solely defined by differences in plant habit, a trait poorly documented in herbaria. To aid species delimitation and taxonomic resolution in M. subser. Obstrigosae, we intended to develop new microsatellite markers. A ddRAD library was constructed from one individual of each M. tandilensis and M. ramulosa species. NGS derived reads were bioinformatically analysed for SSR mining. In order to avoid other sources of variation rather than the intended allelic variants, manual curation was performed. The applied selection criteria retained 72 loci from 495 candidates. Over 22 primer pairs tested, 15 polymorphic SSR were successfully amplified in a 22 individual panel test. Transferability to other species with varying phylogenetic relatedness was successful. A total of 239 variable characters (alleles), scored as presence-absence matrix, allowed to recognize species membership among 30 individuals belonging to four species of M. subser. Obstrigosae; M. adpressa and M. obstrigosa constitute two clear groups, contrarily to M. tandilensis and M. ramulosa that grouped together in several clusters. This pattern supports the hypothesis that the two latter perform a taxonomic complex, coinciding with conflicts to distinguish them by means of morphology. These results suggest that the 15 loci selected are suitable for clarifying species delimitation within M. subser. Obstrigosae. In sum, SSR development based on NGS sequencing and the selection criteria contributed herein provide a valuable tool for the molecular characterization of Mimosa beyond subseries Obstrigosae and may aid SSR development in other polyploid species.
Locating marriageable communities
Creators: name: Yamaura, Chigusa
Publisher: name: No Publisher Supplied
Year: 2013

description: Based on twenty-month multisited ethnography, this dissertation examines contemporary cross-border matchmaking practices between Japan and northeast China. I theorize marriage migration in terms of negotiations of marriageability in the context of regional histories and local marital values. The marriages researched here were arranged during matchmaking tours to northeast China. These matches were contracted shortly after both partners consented. I ask how Japanese men and Chinese women—virtual strangers lacking even a common language with which to communicate—come to see one another as marriageable and, moreover, how matchings between the former colonizers and colonized of Manchuria have come to be viewed as legitimate unions. In order to answer these questions, I seek to reconfigure our understandings of regional interactions and theorize the dynamics of (1) how colonial legacies play a role in contemporary transnational phenomenon, (2) how particular local marital norms and values, such as notions of endogamy, exogamy, or patrilocality inform transnational processes, and (3) how the construction of marriage is made possible by flexible cultural imaginaries and/or normative marital expectations in societies.   Existing work on transnational intimate relations has highlighted gendered imaginings of difference, whereby desire is born of the perception of future spouses as exotic, sensual, traditional, or modern. I argue, instead, that for those involved in the processes of marriage migration between China and Japan, it is the tactical deployment of socially and historically created conceptions of proximity that render their partners marriageable. Current transnational links between Japan and northeast China were originally forged by Japanese colonization of Manchuria and subsequent flows of individuals including repatriation of war orphans and labor migration. Actors on both sides today draw upon these links with conceptions of historical familiarity, racial or cultural similarity, and pseudo kinship terms to legitimate the flows of brides. Moreover, by examining the limits of marriageability in cross-border matchmaking, I also aim to show how such limits reveal marriage normativities. To study these seemingly “uncommon” ways in which marriage is created is to also simultaneously investigate how conceptions of “common” or “regular” marriages are constructed.
Hylambates Dumeril 1853
Creators: name: Badjedjea, Gabriel
name: Masudi, Franck M.
name: Akaibe, Benjamin Dudu
name: Gvoždík, Václav
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Amphibia
Anura
Arthroleptidae
Hylambates

description: Hylambates Duméril, 1853
This genus of the subfamily Kassininae (while the previous genera are representatives of the subfamily Hyperoliinae) was known as Phlyctimantis from the 1950s until recently, when Dubois et al. (2021) pointed out the nomenclatural priority of the nomen Hylambates. These treefrogs have only rarely been encountered in Kokolopori.
description: Published as part of Badjedjea, Gabriel, Masudi, Franck M., Akaibe, Benjamin Dudu & Gvoždík, Václav, 2022, Amphibians of Kokolopori: an introduction to the amphibian fauna of the Central Congolian Lowland Forests, Democratic Republic of the Congo, pp. 35-70 in Amphibian & Reptile Conservation (e 301) (e 301) 16 (1) on page 57, DOI: 10.5281/zenodo.12761585
Breast Cancer and the Environment: Investigating Industry Influence on Scientific Information
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Breast cancer is the most common form of cancer in women, except for skin cancer. Despite better treatments and increased access to care for many women, over 43,000 women still die from the disease each year. Over half of the women diagnosed with breast cancer in the United States have no known risk factors. With family history accounting for only around 10 percent of breast cancer diagnoses, a large and growing body of research indicates that toxic chemicals may increase our risk of developing the disease. Individual solutions like “shopping wisely” and “choosing healthy” are insufficient to stem the driving environmental causes of the breast cancer epidemic.

 The University of California, San Francisco (UCSF) digital Industry Documents Library (IDL) was established in 2002 to house the millions of documents publicly disclosed in litigation against the tobacco industry in the 1990s. It has been expanded to include, chemical, drug, food and fossil fuel industry archives. The IDL is a rich trove of data for research into how an industry manipulated science and public opinion to cast doubt on links between their products and cancer. There are tens of thousands of documents in the tobacco archives, and hundreds in the food and chemical industry archives that contain the term “breast cancer”. However, none of the 800 published journal articles drawing on the IDL have explored this topic.

 This project, which is led by UCSF investigators in collaboration with Breast Cancer Action, will focus on two key questions: 1) is there research in the IDL that shows that the tobacco, chemical, drug, food, and fossil fuel industries had knowledge about the links between environmental exposures and breast cancer that is not known to the public; and 2) are there documents in the IDL that show that these industries tried to reverse public opinion that environmental exposures are causally linked to breast cancer? The project will also include a focus on health equity and health disparities by examining industry advertising and marketing practices specifically targeting traditionally marginalized communities.

 We expect this project to establish whether the IDL is a rich source of data that could illuminate how industries have manipulated science and public opinion to cast doubt on links between their products and breast cancer.
Bathylasmatinae Newman & Ross 1971
Creators: name: Chan, Benny K. K.
name: Dreyer, Niklas
name: Gale, Andy S.
name: Glenner, Henrik
name: Ewers-Saucedo, Christine
name: Pérez-Losada, Marcos
name: Kolbasov, Gregory A.
name: Crandall, Keith A.
name: Høeg, Jens T.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Thecostraca
Balanomorpha
Bathylasmatidae

description: †SUBFAMILY BATHYLASMATINAE NEWMAN & ROSS, 1971 (PALAEOCENE–RECENT)
† Bathylasma Newman & Ross, 1971 (Palaeocene– Recent) (one species)
† Mesolasma Foster, 1981 (Oligocene–Recent) (one species)
†† Tessarelasma Withers, 1936 (Miocene) (two species)
Tetrachaelasama Newman & Ross, 1971 (two species)
description: Published as part of Chan, Benny K. K., Dreyer, Niklas, Gale, Andy S., Glenner, Henrik, Ewers-Saucedo, Christine, Pérez-Losada, Marcos, Kolbasov, Gregory A., Crandall, Keith A. & Høeg, Jens T., 2021, The evolutionary diversity of barnacles, with an updated classification of fossil and living forms, pp. 789-846 in Zoological Journal of the Linnean Society 193 on pages 835-836, DOI: 10.1093/zoolinnean/zlaa160, http://zenodo.org/record/5637275
The antibacterial mode of action and properties of Ib-AMP1, a plant-derived antimicrobial peptide, against Escherichia coli O15&:H&
Creators: name: Wu, Wen-Hsuan
Publisher: name: No Publisher Supplied
Year: 2013

description: The continual occurrence of foodborne outbreaks along with the consumer demand for use of fewer traditional antimicrobial agents in foods has driven research interests in development of plant-derived antimicrobial agents (pAMPs) for use in food and food processing.  Ib-AMP1 is a pAMP isolated from seeds of Impatiens balsamina.  Previous studies indicated that it is a broad spectrum pAMP and the therapeutic index against eight human pathogens was 23.5; however, for future utilization, other antibacterial properties and mode of action must be elucidated.  The purpose of this dissertation was to investigate the antibacterial properties and mode of action of Ib-AMP1 against Escherichia coli O15&:H&, a foodborne pathogen that has been continually associated with foodborne outbreaks.  The study design provided insight on the implantation and potential application of Ib-AMP1; a specific docking site or ligand-receptor relationship was not studied.  The results demonstrated that Ib-AMP1 exhibited bactericidal activity against E. coli O15&:H&, Salmonella enterica serovar Newport, Pseudomonas aeruginosa and Staphylococcus aureus.  Ib-AMP1 at lethal concentrations (1X and 2X MIC) resulted in 1.46 to 2.69 log reduction of viable cells and prevented outgrowth when tested against low (103 CFU/mL) and medium (106 CFU/mL) E. coli O15&:H& populations. Ib-AMP1 at 2X MIC failed to inhibit and prevent outgrowth when cell numbers were 109 CFU/mL.  No residual activity of Ib-AMP1 was apparent following interaction of the peptide with bacteria or the medium.  Ib-AMP1 concentration less than 100 µg/mL showed little or no inhibition of human cell proliferation including human small intestine, colon and liver cells, which are associated with oral consumption of an AMP.  The mode of action study demonstrated that a concentration dependent effect of Ib-AMP1 on the E. coli O15&:H& cell membrane occurred.  Ib-AMP1 treatments resulted in efflux of K+ and ATP, suggesting pores of sufficient size to allow efflux of large molecules.  The efflux of intracellular components may be associated with damage to the outer membrane and dissipation of cytoplasmic membrane potential.  Results of this study suggest Ib-AMP1 is bactericidal interfering within outer and inner membrane integrity permitting efflux of ATP and interfering with intracellular biosynthesis of DNA, RNA, and protein.
Ethnic Enclave Effect on Vietnamese American Women’s Breast Cancer Experience
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Introduction
 We have known about the Healthy Immigrant Effect (HIE) where people who moved to America have better health and lower mortality than the US-born Americans. But we have done very little to understand the HIE and to preserve the factors attributing to better health outcomes. The Vietnamese community in Orange County (OC), California is the largest concentration of Vietnamese outside of Vietnam and has largely maintained its culture, particularly in the “Little Saigon” area, also known to researchers as “Vietnamese ethnic enclave”, where a large number of first-generation Vietnamese immigrants live. Consequently, this makes the Vietnamese community of OC a prime population to explore HIE factors among the growing number of Vietnamese American women who were diagnosed with breast cancer (BC).

 Hypothesis/Questions
 We would like to know: 1) Do Vietnamese women with BC living inside Vietnamese enclave have different experiences and outcomes compared to those living outside of the enclave? 2) What are the factors associated with residential location responsible for positive or negative BC experiences? 3) What can the community do to promote the positive factors by implementing public health programs and collaboration with local institutions?

 General methodology
 Using the California Cancer Registry (CCR) data for OC, we will compare the Vietnamese BC patients who live inside the Vietnamese enclave with those who live outside of the enclave to see any difference in their social and economic characteristics and quality of life after BC. We will also select a sample of Vietnamese survivors to learn about their living environment and BC experience (e.g., screening, diagnosis, treatment, follow-up, and quality of life) through one-on-one in-depth interviews. We will work with the Community Advisory Board (CAB) in every step of the project and share the study findings with the community partners to identify service opportunities to improve BC care and control among Vietnamese American women.

 Innovation and impact
 This is the first attempt to study the ethnic enclave effect on BC experience in the understudied Vietnamese Americans. The potential impact will include raising BC awareness, informing the Vietnamese community partners about the significance of ethnic enclave on health, and creating a new model for BC control among immigrant populations.
Small gases and hydrocarbon adsorption and separation in microporous metal organic frameworks (MMOFs)
Creators: name: Wu, Haohan
Publisher: name: No Publisher Supplied
Year: 2013

description: Microporous Metal Organic Frameworks (MMOFs) materials are very effective and efficient adsorbents for gas adsorption and separation due to their high surface area, large pore volume and relative low heat capacity.  In this work, we focus on small gases and hydrocarbon adsorption and separation properties in MMOFs which typically have pore size smaller than 20Å.  Nitrogen and argon adsorption isotherms were collected at &&K and 8&K respectively for porosity characterization, e. g. surface area, pore volume and pore size distribution. Single component isotherms of small gases of CO2, N2, O2, H2, O2, Alkanes (CnH2n+2) and Alkenes (CnH2n) were collected at ambient condition to preliminarily evaluate gas adsorption and separation properties.  After screening, mixed gas adsorption and breakthrough experiment were performed using promising MMOFs candidates in order to mimic the real world situation.  Besides experiment, molecular simulation was studied in aid of learning adsorption behavior and separation mechanism in depth.  An interesting phenomena, so called “commensurate adsorption”, was recognized and summarized in this thesis.
Favorinus tsuruganus Baba & Abe 1964
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Facelinidae
Favorinus
Favorinus tsuruganus

description: Favorinus tsuruganus Baba & Abe, 1964
(Figure 35 B)
Material examined. Four specimens. MB28-004740, ZA 51, 26 Sep. 2013, 10m, 15mm; MB28-004857, POA, 11 May 2014, 40m, 4mm; MHN-YT1172 & MB28-0 0 4821, POA, 0 7 May 2014, 15m, 6mm and 7mm, respectively.
Habitats. Subtropical rocky reefs.
Occurrences. Ponta do Ouro and Zavora.
Geographic distribution. Indo-west Pacific. New Zealand (Gosliner et al. 2008), Japan (Baba & Abe 1964), Australia (Willan 1983), Papua New Guinea, New Caledonia, Red Sea, Réunion Island (Gosliner et al. 2008) and Mozambique.
Remarks. Specimen MB28-004740 was found feeding on white nudibranch spawn, while MB28-004857 was feeding on the spawn of Hexabranchus sanguineus.
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on page 113, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Hylambates verrucosus Boulenger 1912
Creators: name: Badjedjea, Gabriel
name: Masudi, Franck M.
name: Akaibe, Benjamin Dudu
name: Gvoždík, Václav
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Amphibia
Anura
Arthroleptidae
Hylambates
Hylambates verrucosus

description: Hylambates verrucosus Boulenger, 1912
Fig. 9G–H.
Area: Bechuchuu, Yalokole.
Season/survey: Wet (Nov 2018), dry (July 2020).
Material: CSB:Herp: RNBK 810, 819, 820, 827; NMPP6 V 76085/1–2.
Comments: Individuals of this species were found in forest swamps dominated by plants of the genus Lasimorpha (formerly known as Cyrtosperma). This semiaquatic plant is spiny and may provide some protection from the predators of these frogs. Three anuran species were abundant in this swampy environment, Aubria masako and Chiromantis cf. rufescens in addition to H. verrucosus. In our field experience in central and northeastern DRC, Hylambates is often syntopic with Chiromantis.
description: Published as part of Badjedjea, Gabriel, Masudi, Franck M., Akaibe, Benjamin Dudu & Gvoždík, Václav, 2022, Amphibians of Kokolopori: an introduction to the amphibian fauna of the Central Congolian Lowland Forests, Democratic Republic of the Congo, pp. 35-70 in Amphibian & Reptile Conservation (e 301) (e 301) 16 (1) on page 57, DOI: 10.5281/zenodo.12761585
Hexelasmatinae Newman & Ross 1976
Creators: name: Chan, Benny K. K.
name: Dreyer, Niklas
name: Gale, Andy S.
name: Glenner, Henrik
name: Ewers-Saucedo, Christine
name: Pérez-Losada, Marcos
name: Kolbasov, Gregory A.
name: Crandall, Keith A.
name: Høeg, Jens T.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Thecostraca
Balanomorpha
Bathylasmatidae

description: †SUBFAMILY HEXELASMATINAE NEWMAN & ROSS, 1976 (EOCENE–RECENT)
† Hexelasma Hoek, 1913 (Eocene–Recent) (16 species)
description: Published as part of Chan, Benny K. K., Dreyer, Niklas, Gale, Andy S., Glenner, Henrik, Ewers-Saucedo, Christine, Pérez-Losada, Marcos, Kolbasov, Gregory A., Crandall, Keith A. & Høeg, Jens T., 2021, The evolutionary diversity of barnacles, with an updated classification of fossil and living forms, pp. 789-846 in Zoological Journal of the Linnean Society 193 on page 836, DOI: 10.1093/zoolinnean/zlaa160, http://zenodo.org/record/5637275
Evaluating a multi-component oncofertility care intervention for rural young breast cancer survivors
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: From the time of cancer diagnosis, many young breast cancer survivors (YBCS) ages 15 to 45 experience significant oncofertility issues, i.e., infertility, limited birth control choices, concern about pregnancy safety, and menopause symptoms, which contribute to poorer quality of life. Through oncofertility care (counseling and treatments to reduce infertility risk, manage menopausal symptoms and support shared-decision making on pregnancy and contraception), YBCS can better understand their risks and choose effective treatments. However, delivery of oncofertility care is extremely limited in rural, community oncology settings. In Imperial County, a rural and medically underserved region with a large Latinx population, YBCS face additional language and cultural challenges in accessing this care. Through a community-academic partnership between Cancer Resource Center of the Desert (CRCD) and University of California San Diego (UCSD), the research team developed a new oncofertility care intervention for YBCS in Imperial County that includes four components: (1) oncology clinic-based needs screen; 2) a women’s health survivorship care plan in Spanish and English; 3) remote patient navigation; and 4) telehealth reproductive consultation. In Aim 1, we will conduct a clinical trial to answer our primary research question: Does this multi-component intervention increase YBCS engagement in oncofertility care, i.e., reproductive counseling and/or clinical services that meets their fertility, family planning, pregnancy health and/or menopause symptom needs? In Aim 2, we will collect data on how the intervention fit in and among the two Imperial County oncology clinics, CRCD and UCSD. These implementation data will inform how the intervention can be adapted, what strategies can help other rural oncology settings implement it, and what tools can help in oncofertility patient navigation (Aim 3). Using rigorous methods informed by the needs of this community, the proposal has high potential to improve the reproductive health and quality of life of rural, Latina YBCS.
Grim realities
Creators: name: Wright, Wendy Langum
Publisher: name: No Publisher Supplied
Year: 2013

description: My dissertation develops an account of American punishment that responds to the complex interaction of institutional, intellectual, and cultural attitudes towards punishment, asserting that a careful treatment of penal ideology reveals that the legacy of slavery and Jim Crow play a large role in the development of the contemporary penal system. This dissertation is organized around the justificatory narratives that have long dominated American punishment, and seeks to understand the relationships between normative, cultural, and institutional visions of punishment. I argue that punishment is best understood through a model of the colonial relationship of  “the colonizer and the colonized” (as Memmi framed it).  Through examining the use of retribution, deterrence, and utility as the guiding principles for punishment in the United States, I argue that criminality itself has become divorced from the abstract offending body and has been re-mapped onto already defined bodies, centrally those of poor black men.  In addition to contributing to the emergence of mass incarceration, the displacement of criminality from act to body creates a scenario in which harm itself is ever more difficult to recognize or remediate.  The dissertation concludes with an exploration of possibilities for resisting hegemonic ideologies of punishment through an immanent critique of its reifying effects.
Investigating the roles of alternative RNase P and MRP subunits in stem and cancer cells
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Normal cell homeostasis requires control over the fine balance between differentiation and proliferation. Cancer arises when this balance tilts in favor of proliferation. The accompanying block in differentiation of cancer cells is often characterized by their immortalization and their propensity to self-renew. These hallmarks of cancer cells are shared to a significant extent with the self-renewing population of stem cells, which give rise to more specialized cell types during embryonic development and in the adult.
 In our preliminary survey of molecular traits associated with fast-expanding, non-differentiated cells, we found that the RNA-binding protein Rpp25, a canonical subunit of ribonuclease P (RNase P) and its evolutionary descendant, RNase MRP, is abundantly expressed in mouse embryonic stem cells (ESCs), but is curiously missing in most mammalian somatic tissues. This observation is unexpected given that RNases P and MRP are ubiquitous and essential endonucleases that are critical for maturation of tRNAs and rRNAs, respectively. By contrast, we find that a paralog of Rpp25, a heretofore unstudied RNA-binding protein, Rpp25L, is broadly expressed and appears to be a dominant alternative subunit that replaces Rpp25 in somatic cells. Phenotypic analyses of Rpp25-null ESCs reveals their impaired colony formation and increased propensity towards spontaneous differentiation, whereas Rpp25L-null ESCs appear phenotypically normal. Markedly, akin to ESCs, Rpp25 is highly expressed in several human cancers, most notably melanoma, whereas its paralog shows no significant changes in expression. These results suggest non-overlapping roles of two alternative subunits of RNases P and MRP, with Rpp25 supporting fast expansion and undifferentiated state of stem and cancer cells. Here, we propose to 1) determine the impact of paralogous subunits on processing of tRNA and rRNA precursors, 2) define the effect of Rpp25 and Rpp25L on protein translation, and 3) investigate autonomy of the effects of Rpp25 in normal and cancer cells. This study will shed light on the alternative composition of these ancient ‘housekeeping’ ribozymes and their regulation of the balance between cell proliferation and differentiation, with general implications for cancer development.
Cancer therapeutics via small molecule-mediated p53 mutant reactivation
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: About 600,000 new cancer patients in the United States are diagnosed each year with tumors expressing mutated p53. These cancers express full length p53 that has lost tumor suppressor activity but acquired gain-of-function oncomorphic properties that provide selective advantage to cancer cells. The large number of affected cancers make p53 an exquisite target for cancer therapy. However, therapeutic approaches require reactivation of mutated p53, which in itself is challenging. Reactivation of mutant p53 is possible through both intragenic second site mutations and small molecules that induce a conformational change and stabilize an active conformation of p53 hotspot mutants. We have developed a compound series that binds mutant p53 and thereby restores DNA binding activity of mutant p53 in a reconstituted purified in vitro system. Furthermore, cell proliferation is halted, and apoptosis is induced in a p53 mutant dependent manner. Importantly, growth of tumors carrying p53 mutants is blocked by this compound series in animal models. These compounds provide strong support for feasibility to develop drug-like molecules that can restore tumor suppressor activity in p53 hotspot mutants. However, these compounds act in the micromolar range and moving from these preclinical successes towards the bedside requires more lead compound series with diverse chemistry, and most importantly, a better understanding of the mechanisms underlying p53 mutant reactivation as well as the identification of key features that determine potency of tumor suppression in the reactivation process. We propose to develop such mechanistic understanding by detailed characterization of p53 hotspot mutant reactivation by small molecules as well as second site mutations. The proposal will generate molecular understanding of key features that allow reactivation of tumor suppression activity of p53 cancer mutants. Such understanding will help the identification of new p53 reactivation lead compounds in the future. The therapeutic concept of p53 mutant reactivation could transform treatment for many cancer patients, but lack of experience with reactivation drug development makes it difficult to achieve this goal. Building detailed molecular knowledge about the reactivation process will overcome these current roadblocks.
The timing of mediation
Creators: name: Winkel, Christian
Publisher: name: No Publisher Supplied
Year: 2013

description: The peaceful settlement of civil wars represents a key challenge for the international community and its policymakers. Even though mediation has become the most common tool of conflict management to settle these conflicts, so far we know relatively little about how to best manage them. This thesis examines mediation in civil wars and by building on the bargaining model of war the author argues that mediators have to concentrate primarily on the resolution of commitments problems in order to establish robust peace agreements. This paper uses an edited version of the Civil War Mediation (CWM) dataset, which comprises 366 mediation events in the time period of 1946 to 2004. By employing logistic regression analyses, the author finds that the later the intermediary enters a conflict, the lower the development and democracy level of the respective state, and the more intense a conflict is, the higher is the probability of a successful mediation outcome. The results also suggest that international and regional organizations are better equipped than other mediators to resolve commitment problems.
Black nuns and the struggle to desegregate Catholic America after World War I
Creators: name: Williams, Shannen Dee
Publisher: name: No Publisher Supplied
Year: 2013

description: Since 1824, hundreds of black women and girls have embraced the religious state in the U.S. Catholic Church. By consecrating their lives to God in a society that deemed all black people immoral, black Catholic sisters provided a powerful refutation to the racist stereotypes used by white supremacists and paternalists to exclude African Americans from the ranks of religious life and full citizenship rights. By dedicating their labors to the educational and social uplift of the largely neglected black community, black sisters challenged the Church and the nation to live up to the full promises of democracy and Catholicism. Yet, their lives and labors remain largely invisible in the annals of American and religious history. This is especially true of their efforts in the twentieth century, when black sisters pried opened the doors of Catholic higher education, desegregated several historically white congregations, and helped to launch the greatest black Catholic revolt in American history.    This dissertation unearths the hidden history of black Catholic sisters in the fight for racial and educational justice in the twentieth century. Specifically, it chronicles the diverse and strategic efforts of black nuns in the long fight to secure African-American access to religious life and Catholic education after World War I. Drawing upon previously-ignored archival sources, oral history interviews, and a host of secular and religious periodicals, this study argues that black sisters are the forgotten prophets of American Catholicism and democracy. Though practically invisible in the scholarship on the African-American freedom struggle and the Catholic Church, black sisters played critical and leading roles in the fight to dismantle barriers in the white-dominated, male-hierarchal Church. By demanding adherence to canon law and Catholic social teachings, black sisters were instrumental in forcing Church leaders to adopt progressive stances on issues such as black Catholic education, the development of African-American priests and sisters, and briefly black liberation. While resistance campaigns to equity and justice proved strident and largely successful, black sisters nonetheless endowed the Catholic Church with a rich tradition of righteous struggle against racial and gender injustice and faithfulness unparalleled in the United States.
Favorinus Gray 1850
Creators: name: Tibiriçá, Yara
name: Pola, Marta
name: Cervera, Juan Lucas
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Nudibranchia
Facelinidae
Favorinus

description: Favorinus sp.
(Figure 35 C)
Material examined. One specimen. MB28-005050, NGF, 2 July 2016, 30m, 17mm. Habitats. Tropical coral reef on Hexabranchus sanguineus spawn. Occurrences. Nuarro.
Geographic distribution. Indo-west Pacific. Philippines (Gosliner et al. 2015), Reunion (Bachel 2009), Mayotte, Mauritius (Poddubetskaia 2002) and Mozambique.
description: Published as part of Tibiriçá, Yara, Pola, Marta & Cervera, Juan Lucas, 2017, Astonishing diversity revealed: an annotated and illustrated inventory of Nudipleura (Gastropoda: Heterobranchia) from Mozambique, pp. 1-133 in Zootaxa 4359 (1) on page 113, DOI: 10.11646/zootaxa.4359.1.1, http://zenodo.org/record/1069168
Electrical Impedance Spectroscopy for Monitoring the Chemoresistance of Prostate Cancer Cells
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Prostate cancer is a life altering disease that affects one in six men in the United States. A challenge in treating prostate cancer cells is overcoming their plasticity. Cancer cells have subpopulations of stem cells that can switch phenotypes, converting between chemoresistant and non-chemoresistant cells. In particular, the epithelial mesenchymal transition (EMT) is linked to chemoresistance and the presence of cancer stem cells. EMT is a reversible process in which cells lose their epithelial features and gain mesenchymal features. The goal of this proposal is to monitor EMT to gain a deeper understanding of chemoresistant cells and the time scale at which change occurs. A custom electrode-based microfluidic device will be used to measure dynamic changes in impedance at the single cell level. Electrical impedance spectroscopy is a cell analysis technique that offers a label-free approach for the recognition of cancer cells, their dynamics, and chemoresistance using electric fields.

 Our central hypothesis is that impedance is a good candidate for the detection of prostate cancer cells’ EMT, which is associated with the presence of cancer stem cells. We have preliminary data that indicates impedance detects: (a) stages of prostate cancer cells, stage 4 (PC-3) and stage 1 (DU145) and (b) phenotype differences in PC-3 and DU145 cells cultured as monolayer (less chemoresistant) versus suspension (more chemoresistant). Also, we have found correlations between impedance and the gene expression of N-cadherin, E-cadherin, and ZO-1 proteins (markers of EMT).

 The following aims will be tested, Aim 1: Characterize the baseline impedance spectra and functional profile of PC-3, DU145, LnCAP and patient samples. Aim 2: Modulate the EMT of PC-3, DU145, LnCAP and patient samples using transforming growth factor b (TGF-b), hypoxia inducible factor 1 alpha subunit (HIF-1a), and estrogen receptor alpha (ER-a) and quantify the impedance spectra and functional profile. Impedance measurements will be coupled with cell proliferation, cell cycle analysis, apoptosis, and gene expression assays.

 At the end of these studies impedance and membrane capacitance will be quantified and screened as potential biomarkers of EMT. This work will lay the foundation toward the development of potential EMT-specific drug therapies for prostate cancer.
Additional file 1: of A scoping review of palliative care for children in low- and middle-income countries
Creators: name: Hatoko Sasaki
name: Marie-Charlotte Bouesseau
name: Marston, Joan
name: Rintaro Mori
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The discription of the search strategy. (DOCX 20 kb)
Irregular bodies
Creators: name: Williams, Katherine Schaap
Publisher: name: No Publisher Supplied
Year: 2013

description: “Irregular” bodies—described as deformed, foul, ugly, maimed, crooked, limping, sick, and infected—appear everywhere in the English drama of the sixteenth and seventeenth centuries. My dissertation asks: what accounts for the theater’s fascination with these bodies, and what, exactly, can “disability” mean on the early modern stage? I read plays by Shakespeare, Dekker, Heywood, Rowley, Jonson, and Middleton (among others), alongside medical manuals, conduct books, and legal codes, to explore how dramatic representations expose the vexed and shifting standards that dictate bodily norms in the period. Drawing upon contemporary work in disability theory, I show how these standards at once constrain and depend upon irregular bodies. I argue that irregular bodies make possible a range of early modern social formations—not only medical knowledge or aesthetic standards of beauty, but also concepts of political power, citizenship, social status, and economic exchange. Theorizing disability through social structures allows us to see how theatrical representations of irregular bodies cut across distinctions—between art and nature, form and matter, public and private—foundational to early modern thought. Bringing disability to the stage, early modern drama highlights the impossible ideals of social order that depend upon excluding irregular bodies and the vibrant re-orderings these bodies elicit.
The hunt for knowledge
Creators: name: Whitlatch, Lisa A.
Publisher: name: No Publisher Supplied
Year: 2013

description: My dissertation explores the use of hunting in five didactic poems as a means to characterize their attitudes towards the human ability to acquire true understanding. Lucretius’ De Rerum Natura, Vergil’s Georgics, Ovid’s Ars Amatoria, Grattius’ Cynegetica and Nemesianus’ Cynegetica—didactic poems written in Latin from the first century BCE to the third century CE—respond to questions of human perception and knowledge in different ways, but they all use the hunt to represent the human search. Lucretius’ De Rerum Natura uses hunting as a metaphor for the reader’s actions, and parallels himself, his philosophical forefather Epicurus, and the reader to dogs hunting out proofs and ataraxia, “freedom from care,” the goal or prey of the Epicurean hunt. According to Lucretius, this hunt has the potential to be successful: humankind can obtain its ultimate goal of ataraxia if it follows Epicureanism. Vergil’s Georgics is less optimistic about the ability of humankind to be successful in their hunt for knowledge. Farmers, the protagonists of the Georgics, are presented as knowing how to hunt and can follow the tracks of Justice, but there is no indication that they obtain it. The poem closes with the myth of Aristaeus, which displays the deceitful nature of prey (Proteus) to humankind (Aristaeus) and presents man’s imperfect methods for capturing knowledge. Ovid’s Ars Amatoria, a playful didactic about seduction, similarly puts forth a pessimistic view of human knowledge via hunting metaphors. The reader’s education, presented as a hunt for the beloved, ultimately backfires and his knowledge fails him, as violently allegorized in the myth of Cephalus and Procris in Book 3. Grattius’ Cynegetica makes the figurative use of the hunt into the literal subject of the poem, but Grattius’ hunting poem is also an exploration of knowledge and morality. It reasserts an optimistic view of knowledge while at the same correcting Lucretius’ Epicurean moral and religious views. I finish by looking at Nemesianus’ Cynegetica, which provides a useful contrast to the previous works since the surviving fragment turns away from metaphysical and epistemological questions in favor of practical advice and literary reflection.
Rebuilding the past
Creators: name: Watnik, Zoe
Publisher: name: No Publisher Supplied
Year: 2013

description: Authenticity refers not only to the physical characteristics of cultural properties, but also to the ways in which collective memories connect with particular environments. Each historic site presents a unique interpretation of authenticity, rooted in a combination of the material, contextual, and cultural realms. Preservation standards have emerged to answer a number of questions regarding the need to develop guidelines for conservation of historic properties. This thesis addresses 90 years of cultural preservation policy through international standard-setting instruments, including the Athens Charter of 1931, the Venice Charter of 1964, UNESCO&2, the World Heritage Operational Guidelines, the 1994 Nara Recommendation on Authenticity, and the 2011 Recommendation on the Historic Urban Landscape, as well as core United States federal preservation legislation, including the National Historic Preservation Act of 1966 and the Secretary of Interior’s Standards and Guidelines for the Treatment of Historic Properties. These documents are examined for the specific framing of reconstruction actions, and the ways in which major interventions may simultaneously bolster and compromise authenticity of a historic property. Four case studies, the Lower East Side Tenement Museum in Manhattan, New York; the Ise Temple complex in Japan; the rebuilt Frauenkirche in Dresden, Germany; and the Abu Simbel temple complex located near Aswan, Egypt, contribute to the discussions surrounding authenticity. Each site explored in this paper further illustrates the difficulties emerging from attempts to establish a uniform method of preservation interventions across a range of heritage sites. Modern, flexible preservation tools will establish the groundwork for new approaches to authenticity that accurately reflect the multifaceted significance of the global cultural environment and contribute to contemporary discussions on sustainable development.