cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The reality of the process of sports selection for school teams in handball from the point of view of physical education teachers
Creators: name: Rebbouh, Abdenacer
name: Kenioua, Mouloud
name: Zeroual, Mohammed
Publisher: name: Zenodo
Year: 2023
Subjects: sports selection; school teams; handball; school sports.

description: The Object of the study aims to identify the reality of the sports selection process for school teams in handball from the point of view of physical education teachers, for this purpose, we used the descriptive method on a sample composed of 50 physical education teachers. Chosen as randomly, and for data collection, we used a questionnaire After collecting the results and having treated them statistically, we conclude that the process of sports selection for the school teams is subject to the foundations and scientific standards by the physicaleducation teacher, in addition to that there are no statistically significant differences between the teachers of physical education in the selection process for the school teams in handball due to the professional experience. On this basis, the study recommended that it is necessary to improve working conditions for physical ducation teachers by providing all the capabilities and means required by the selection process for school teams
Cloning and functional characterization of a novel mitochondrial N-ethylmaleimide-sensitive glycerol-3-phosphate acyltransferase (GPAT2)
Creators: name: Wang, Shuli
name: Lewin, Tal M.
name: Mashek, Douglas G.
name: Lee, Douglas P.
name: Coleman, Rosalind A.
name: Gonzalez-Baró, Maria R.
name: Li, Lei O.
name: Schwerbrock, Nicole M.J.
name: Gong, Nan
name: Stapleton, Cliona
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the initial and rate-limiting step in glycerolipid synthesis. Several mammalian GPAT activities have been recognized, including N-ethylmaleimide (NEM)-sensitive isoforms in microsomes and mitochondria and an NEM-resistant form in mitochondrial outer membrane (GPAT1). We have now cloned a second mitochondrial isoform, GPAT2 from mouse testis. The open reading frame encodes a protein of 798 amino acids with a calculated mass of 88.8 kDa and 27% amino acid identity to GPAT1. Testis mRNA expression was 50-fold higher than in liver or brown adipose tissue, but the specific activity of NEM-sensitive GPAT in testis mitochondria was similar to that in liver. When Cos-7 cells were transiently transfected with GPAT2, NEM-sensitive GPAT activity increased 30%. Confocal microscopy confirmed a mitochondrial location. Incubation of GPAT2-transfected Cos-7 cells with trace (3 μM; 0.25μCi) [1-14C]oleate for 6 h increased incorporation of [14C]oleate into TAG 84%. In contrast, incorporation into phospholipid species was lower than in control cells. Although a polyclonal antibody raised against full-length GPAT1 detected an ∼89 kDa band in liver and testis from GPAT1 null mice and both 89 and 80 kDa bands in BAT from the knockout animals, the GPAT2 protein expressed in Cos-7 cells was only 80 kDa. In vitro translation showed a single product of 89 kDa. Unlike GPAT1, GPAT2 mRNA abundance in liver was not altered by fasting or refeeding. GPAT2 is likely to have a specialized function in testis.
Selective degradation of mitochondria by mitophagy
Creators: name: Lemasters, John J.
name: Rodriguez-Enriquez, Sara
name: Kim, Insil
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Mitochondria are the essential site of aerobic energy production in eukaryotic cells. Reactive oxygen species (ROS) are an inevitable by-product of mitochondria metabolism and can cause mitochondrial DNA mutations and dysfunction. Mitochondrial damage can also be the consequence of disease processes. Therefore, maintaining a healthy population of mitochondria is essential to the well-being of cells. Autophagic delivery to lysosomes is the major degradative pathway in mitochondrial turnover, and we use the term mitophagy to refer to mitochondrial degradation by autophagy. Although long assumed to be a random process, increasing evidence indicates that mitophagy is a selective process. This review provides an overview of the process of mitophagy, the possible role of the mitochondrial permeability transitionin mitophagy and the importance of mitophagy in turnover of dysfunctional mitochondria.
title: Faut-il remettre en question les baisses de cotisations sociales ? (Débats du LIEPP, n°2)
Creators: name: Carbonnier, Clément
name: Palier, Bruno
name: Zemmour, Michaël
name: L'Horty, Yannick
name: Tavernier, Jean-Luc
Publisher: name: Sciences Po - LIEPP
Year: 2015
Subjects: subject: FOS: Social sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: La France est fréquemment décrite comme l’un des pays où les prélèvements obligatoires sont parmi les plus élevés du monde. Cependant, une autre réalité française, moins connue, doit aussi être prise en compte: la France est également l’un des pays où les politiques d’exemption fiscale et d’exonération de cotisations sociales sont les plus développées. En 2011, l’ensemble des politiques socio-fiscales ayant trait à la protection sociale et à l’emploi représentait une valeur comptable de 94 milliards d’euros (Zemmour 2013). Parmi ces politiques, la stratégie française pour l’emploi, qui met en œuvre une réduction du coût du travail, occupe une place importante. Deux programmes visent spécifiquement à faire baisser le coût du travail des emplois peu qualifiés : les exonérations générales de cotisations employeur et les dispositifs concernant l’emploi de salariés à domicile. Les pertes de recettes fiscales et sociales au titre des deux politiques représentaient en 2011 27 milliards d’euros soit 1,3 point de PIB.
Protein folding: Then and now
Creators: name: Ding, Feng
name: Sharma, Shantanu
name: Serohijos, Adrian W.
name: Yin, Shuangye
name: Chen, Yiwen
name: Wilcox, Kyle C.
name: Nie, Huifen
name: Dokholyan, Nikolay V.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Over the past three decades the protein folding field has undergone monumental changes. Originally a purely academic question, how a protein folds has now become vital in understanding diseases and our abilities to rationally manipulate cellular life by engineering protein folding pathways. We review and contrast past and recent developments in the protein folding field. Specifically, we discuss the progress in our understanding of protein folding thermodynamics and kinetics, the properties of evasive intermediates, and unfolded states. We also discuss how some abnormalities in protein folding lead to protein aggregation and human diseases.
Additional file 5 of A promising resilience parameter for breeding: the use of weight and feed trajectories in growing pigs
Creators: name: Gorssen, Wim
name: Winters, Carmen
name: Meyermans, Roel
name: Chapard, Léa
name: Hooyberghs, Katrijn
name: Janssens, Steven
name: Huisman, Abe
name: Peeters, Katrijn
name: Mulder, Han
name: Buys, Nadine
Publisher: name: figshare
Year: 2023
Subjects: subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: Additional file 5: Fig. S3. Pairwise correlation plots for all evaluated traits with full datasets and reduced datasets.
SO(10) Grand Unification in M theory on a G2 manifold
Creators: name: Acharya, Bobby S.
name: Bożek, Krzysztof
name: Romão, Miguel Crispim
name: King, Stephen F.
name: Pongkitivanichkul, Chakrit
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider Grand Unified Theories based on $SO(10)$ which originate from string/$M$ theory on $G_2$ manifolds or Calabi-Yau spaces with discrete symmetries. In this framework we are naturally led to a novel solution of the doublet-triplet splitting problem previously considered by Dvali which involves an extra vector-like Standard Model family and light, but weakly coupled colour triplets. These additional states are predicted to be accessible at the LHC and also induce R-parity violation. Gauge coupling unification occurs with a larger GUT coupling.
description: 5 pages, added references, revised argument on equation 18, results unchanged, a new example is given in equation 24, agrees with published version in Physical Review D
CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases
Creators: name: Sadeghi, Sheila
name: Wiertz, Emmanuel
name: Pabarcus, Michael K.
name: Correia, Maria Almira
name: Hoe, Nicholas
name: Patterson, Cam
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Human liver CYP3A4 is an endoplasmic reticulum (ER)-anchored hemoprotein responsible for the metabolism of >50% of clinically prescribed drugs. After heterologous expression in Saccharomyces cerevisiae,it is degraded via the ubiquitin (Ub)-dependent 26S proteasomal pathway that utilizes Ubc7p/Cue1p, but none of the canonical Ub-ligases (E3s) Hrd1p/Hrd3p, Doa10p, and Rsp5p involved in ER-associated degradation (ERAD). To identify an Ub-ligase capable of ubiquitinating CYP3A4, we examined various in vitro reconstituted mammalian E3 systems, using purified and functionally characterized recombinant components. Of these, the cytosolic domain of the ER-protein gp78, also known as the tumor autocrine motility factor receptor (AMFR), an UBC7-dependent polytopic RING-finger E3, effectively ubiquitinated CYP3A4 in vitro, as did the UbcH5a-dependent cytosolic E3 CHIP. CYP3A4 immunoprecipitation coupled with anti-Ub immunoblotting analyses confirmed its ubiquitination in these reconstituted systems. Thus, both UBC7/gp78 and UbcH5a/CHIP may be involved in CYP3A4 ERAD, although their relative physiological contribution remains to be established.
Blood shear stress and flow velocity : challenges for laser coagulation and hemostasis of large vessels
Creators: name: Katta, Nitesh
name: 0000-0001-8097-5489
Publisher: name: The University of Texas at Austin
Year: 2019
Subjects: Hemostasis
Laser
Photothermolysis
Coagulation
CAMs
Chorio-allantoic membrane
Laser coagulation
Blood vessel coagulation
Photo-coagulation
OCT
Optical coherence tomography

description: Photo-coagulation of blood vessels offers stark advantages to current radiofrequency mediated devices, given the high specificity of blood absorption wavelengths (like 532nm, 1.064 μm). Existing literature has documented coagulation in treatment of pediatric vascular diseases like port-wine stains for microvascular hemostasis. Although laser treatments have been successful in smaller diameter blood vessels, treatment of larger sized vessels are less effective in achieving hemostasis. This report investigates the hypothesis that a primary limitation in coagulation of larger sized vessels comes from shear stress gradients with higher flow velocities along with temperature dependent viscosity changes. Laser coagulation at the 1.07 μm wavelength is tested in the chicken chorio-allantoic membrane (CAM) model highlighting limitations reported in the archival literature. COMSOL based finite element models are presented which includes hypothetical limitations in coagulation during laser irradiation. Laser fluence rate and dosimetry are adjusted based on experimental OCT imaging and angiography observations as well as COMSOL models to test the hypothesis that blood shear stress and flow velocity are important challenges for laser coagulation and hemostasis of large vessels
MPEC 2023-U122 : 2023 TF32
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2023
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2023 TF32

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Gronwall's conjecture for 3-webs with infinitesimal symmetries
Creators: name: Agafonov, Sergey I.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 53A60

description: We study non-flat planar 3-webs with infinitesimal symmetries. Using multi-dimensional Schwarzian derivative we give a criterion for linearization of such webs and present a projective classification thereof. Using this classification we show that the Gronwall conjecture is true for 3-webs admitting infinitesimal symmetries.
description: 20 pages
Ethanol exposure decreases mitochondrial outer membrane permeability in cultured rat hepatocytes
Creators: name: Lemasters, John J.
name: Holmuhamedov, Ekhson
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Mitochondrial metabolism depends on movement of hydrophilic metabolites through the mitochondrial outer membrane via the voltage-dependent anion channel (VDAC). Here we assessed VDAC permeability of intracellular mitochondria in cultured hepatocytes after plasma membrane permeabilization with 8 μM digitonin. Blockade of VDAC with Koenig's polyanion inhibited uncoupled and ADP-stimulated respiration of permeabilized hepatocytes by 33% and 41%, respectively. Tenfold greater digitonin (80 μM) relieved KPA-induced inhibition and also released cytochrome c, signifying mitochondrial outer membrane permeabilization. Acute ethanol exposure also decreased respiration and accessibility of mitochondrial adenylate kinase (AK) of permeabilized hepatocytes membranes by 40% and 32%, respectively. This inhibition was reversed by high digitonin. Outer membrane permeability was independently assessed by confocal microscopy from entrapment of 3 kDa tetramethylrhodamine-conjugated dextran (RhoDex) in mitochondria of mechanically permeabilized hepatocytes. Ethanol decreased RhoDex entrapment in mitochondria by 35% of that observed in control cells. Overall, these results demonstrate that acute ethanol exposure decreases mitochondrial outer membrane permeability most likely by inhibition of VDAC.
Sport policy, citizenship and the social integration of immigrants in Denmark
Creators: name: Chatzopoulos, Ioannis
Publisher: name: Figshare
Year: 2019
Subjects: subject: 119999 Medical and Health Sciences not elsewhere classified
subject: FOS: Other medical sciences

description: Since 2010 Denmark has seen a significant increase in immigration and the topic has become a significant political issue linked to the rise of far-right political parties that advocate not only a more restrictive immigration policy but also the assimilation strategy for those migrants currently resident in the country. The aim of this thesis is to analyze the development of sport policies in two Danish cities in relation to migration since 2010. The research analyses changes in national level policy and in the policies of Copenhagen and Aarhus, in which three sports projects are examined to explore the impact on policy of the interaction between national, municipal and sports club policy actors. Data were collected through a combination of semi-structured interviews with municipal civil servants, administrative and coaching staff of sports clubs and a review of material derived from official municipal and sports club documents and media reports. The data were subject to thematic content analysis. The theoretical foundation for the data collection and analysis was provided by the advocacy coalition framework and the multiple streams framework. Moreover, macro-level theories with neo-corporatism and neo-pluralism were particularly significant. Neo-corporatism was significant because of its connection with associationalism which remains strong at the local level, whereas neo-pluralism was dominant at the national level.   The main findings of the research were: a) sport was identified in both cities as an important vehicle for the inclusion of recent migrants into the communal associationalist life and their introduction to the Danish societal values and norms; b) municipalities were granted by central government considerable autonomy in interpreting their responsibilities and collaborated closely with sports clubs in the design and delivery of sports programmes related to immigrants; c) two competing advocacy coalitions were identified, one favouring inclusion through assimilation and the other integration through multiculturalism; d) the assimilationist coalition was composed of by centre-right and far-right political parties and where they controlled the municipal sport department it was the sports clubs that pursued an integration/ multicultural policy; e) in both cities the most conflicting issue was gender segregated swimming; and f) in both cities Get2Sport Project was a significant link between the local sports clubs and the Danish Sport Confederation (DIF).
Closure of VDAC causes oxidative stress and accelerates the Ca2+-induced mitochondrial permeability transition in rat liver mitochondria
Creators: name: Tikunov, Andrey
name: Macdonald, Jeffrey M.
name: Johnson, C. Bryce
name: Pediaditakis, Peter
name: Holmuhamedov, Ekhson
name: Lemasters, John J.
name: Markevich, Nikolai
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The electron transport chain of mitochondria is a major source of reactive oxygen species (ROS), which play a critical role in augmenting the Ca2+-induced mitochondrial permeability transition (MPT). Mitochondrial release of superoxide anions (O2•-) from the intermembrane space (IMS) to the cytosol is mediated by voltage dependent anion channels (VDAC) in the outer membrane. Here, we examined whether closure of VDAC increases intramitochondrial oxidative stress by blocking efflux of O2•- from the IMS and sensitizing to the Ca2+-induced MPT. Treatment of isolated rat liver mitochondria with 5 µM G3139, an 18-mer phosphorothioate blocker of VDAC, accelerated onset of the MPT by 6.8 ± 1.4 min within a range of 100–250 µM Ca2+. G3139-mediated acceleration of the MPT was reversed by 20 µM butylated hydroxytoluene, a water soluble antioxidant. Pre-treatment of mitochondria with G3139 also increased accumulation of O2•- in mitochondria, as monitored by dihydroethidium fluorescence, and permeabilization of the mitochondrial outer membrane with digitonin reversed the effect of G3139 on O2•- accumulation. Mathematical modeling of generation and turnover of O2•- within the IMS indicated that closure of VDAC produces a 1.55-fold increase in the steady-state level of mitochondrial O2•-. In conclusion, closure of VDAC appears to impede the efflux of superoxide anions from the IMS, resulting in an increased steady-state level of O2•-˜, which causes an internal oxidative stress and sensitizes mitochondria toward the Ca2+-induced MPT.
Living and dying in early modern Surrey: aspects of Surrey's demography c1550-1750
Creators: name: Jones, Susan
Publisher: name: Archaeology Data Service
Year: 2023

description: Surrey Archaeological Collections, 105, 73-110
description: Taking a parish-level framework of analysis, this article considers aspects of the demography of non-metropolitan Surrey, that is the majority of the historical county of Surrey excluding only those parishes that were in practice subsumed within Surrey's neighbour, London. It explores the size and distribution of the area's population and its patterns of mortality both in times of crisis and in normal times. The geographical and temporal patterns of these demographic characteristics further suggest some broad economic differences across the area. It is hoped the study will form a basis for comparisons of non-metropolitan Surrey with other areas and also provide a context for more detailed studies of specific localities within the county.
New results for electromagnetic quasinormal and quasibound modes of Kerr black holes
Creators: name: Staicova, Denitsa
name: Fiziev, Plamen
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The perturbations of the Kerr metric and the miracle of their exact solutions play a critical role in the comparison of predictions of general relativity with astrophysical observations of compact massive objects. The differential equations governing the late-time ring-down of the perturbations of the Kerr metric, the Teukolsky Angular Equation and the Teukolsky Radial Equation, can be solved analytically in terms of confluent Heun functions. In this article, we solve numerically the spectral system formed by those exact solutions and we obtain the electromagnetic (EM) spectra of the Kerr black hole. Because of the novel direct way of imposing the boundary conditions, one is able to discern three different types of spectra: the well-known quasinormal modes (QNM), the symmetric with respect to the real axis quasibound modes (QBM) and a spurious spectrum who is radially unstable. This approach allows clearer justification of the term "spurious" spectrum, which may be important considering the recent interest in the spectra of the electromagnetic counterparts of events producing gravitational waves.
description: 12 pages, 8 figures, some sections reworked and new comments added, final published version. arXiv admin note: substantial text overlap with arXiv:1112.0310
Concussion Symptom Inventory: An Empirically Derived Scale for Monitoring Resolution of Symptoms Following Sport-Related Concussion
Creators: name: Millis, S.
name: Hammeke, T. A.
name: McCrea, M.
name: Barr, W. B.
name: Randolph, C.
name: Kelly, J. P.
name: Guskiewicz, K. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Self-report post-concussion symptom scales have been a key method for monitoring recovery from sport-related concussion, to assist in medical management, and return-to-play decision-making. To date, however, item selection and scaling metrics for these instruments have been based solely upon clinical judgment, and no one scale has been identified as the “gold standard”. We analyzed a large set of data from existing scales obtained from three separate case–control studies in order to derive a sensitive and efficient scale for this application by eliminating items that were found to be insensitive to concussion. Baseline data from symptom checklists including a total of 27 symptom variables were collected from a total of 16,350 high school and college athletes. Follow-up data were obtained from 641 athletes who subsequently incurred a concussion. Symptom checklists were administered at baseline (preseason), immediately post-concussion, post-game, and at 1, 3, and 5 days post-injury. Effect-size analyses resulted in the retention of only 12 of the 27 variables. Receiver-operating characteristic analyses were used to confirm that the reduction in items did not reduce sensitivity or specificity. The newly derived Concussion Symptom Inventory is presented and recommended as a research and clinical tool for monitoring recovery from sport-related concussion.
Additional file 1 of deepGBLUP: joint deep learning networks and GBLUP framework for accurate genomic prediction of complex traits in Korean native cattle
Creators: name: Lee, Hyo-Jun
name: Lee, Jun Heon
name: Gondro, Cedric
name: Koh, Yeong Jun
name: Lee, Seung Hwan
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Figure S1. QTL mapping with deepGBLUP for a single QTL effect. We simulated heritability 0.5 across QTL effects including additive, dominance, and epistasis. (a) for additive QTL, (b) for dominance QTL, and (c) for epistasis QTL. Figure S2. QTL mapping with deepGBLUP for two QTL effects. We simulated heritability 0.5 across QTL effects including additive, dominance, and epistasis. (a) for additive+dominance QTL, (b) for additive+epistasis QTL, and (c) for dominance+epistasis QTL. Figure S3. QTL mapping with deepGBLUP for three QTL effects. We simulated heritability 0.5 across QTL effects including additive, dominance, and epistasis. (a) for additive+dominance+epistasis QTL.
[Opuscula varia]
Creators: name: Cousin, Gilbert
Publisher: name: [s.n.]
Year: 1500

description: Gilbertus Cognatus
description: Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Verzeichnung=Description=Inventaire Dez. 2009 und März 2016 HAN-Katalogisierungsregeln Minimalaufnahme nach: Steinmann, Inventar, 1970
description: Erschliessungsniveau Minimalniveau
Neurocognitive Function Among Middle-aged and Older Hispanic/Latinos: Results from the Hispanic Community Health Study/Study of Latinos
Creators: name: Catellier, Diane J.
name: Lipton, Richard B.
name: Argüelles, William
name: Choca, James P.
name: González, Hector M.
name: Gouskova, Natalia
name: Davis, Sonia M.
name: Gallo, Linda C.
name: Tarraf, Wassim
name: Penedo, Frank J.
name: Mosley, Thomas H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: We sought to examine and describe neurocognitive function among middle-aged and older Hispanic/Latino Hispanic Community Health Study/Study of Latinos (HCHS/SOL) participants. We analyzed baseline cross-sectional data from the middle-aged and older (ages 45–74 years old) participants (n = 9,063) to calculate neurocognitive function scores and their correlates. Older age and higher depressive symptoms scores were associated with lower average neurocognitive performance, whereas greater educational attainment and household income were associated with higher neurocognitive performance. Hispanic/Latino heritage groups significantly varied in neurocognitive performances. Some neurocognitive differences between Hispanics/Latinos were maintained after controlling for language preference, education, household income, and depressive symptoms. We found notable differences in neurocognitive scores between Hispanic/Latino heritage groups that were not fully explained by the cultural and socioeconomic correlates examined in this study. Further investigations into plausible biological and environmental factors contributing to the Hispanic/Latino heritage group differences in neurocognitive found in the HCHS/SOL are warranted.
Home Farm Quarry, Laleham: Neolithic, earliest Iron Age and Anglo-Saxon occupation
Creators: name: Davies, Alex
name: Welsh, Ken
name: Hayden, Chris
name: Allen, Martyn G
name: Cook, Sharon
name: Donnelly, Michael
name: Meen, Julia
name: Poole, Cynthia
name: Shaffrey, Ruth
Publisher: name: Archaeology Data Service
Year: 2023

description: Surrey Archaeological Collections, 105, 111-146
description: Excavations at Home Farm Quarry, Laleham revealed occupation dating to the Neolithic, the earliest Iron Age and the early-middle Anglo-Saxon periods. The earliest feature on the site appears to have been a silted-up palaeochannel (former watercourse), which cannot be dated precisely. A ring ditch, almost entirely devoid of finds, could be Neolithic but its date is, again, uncertain. A small pit that contained Grooved Ware can be more certainly dated to the late Neolithic, and two other pits might have belonged to the same period. The most extensive remains belong to an earliest Iron Age field system that was associated with waterholes and a few pits and postholes. A complete decorated socketed axehead of Sompting type was found in the base of one of the waterholes, below a large deposit of freshly broken pottery. Activity in the early-middle Anglo-Saxon period is represented by only a few features - three pits and possibly a waterhole and a short stretch of ditch - but charred plant remains including free-threshing wheat, likely to be Anglo-Saxon in date, were widely distributed across the site.
Experimental models for the autoimmune and inflammatory blistering disease, Bullous pemphigoid
Creators: name: Li, Ning
name: Leighty, Lisa
name: Liu, Zhi
name: Diaz, Luis A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Bullous pemphigoid (BP) is a subepidermal skin blistering disease characterized immunohistologically by dermal-epidermal junction (DEJ) separation, an inflammatory cell infiltrate in the upper dermis, and autoantibodies targeted toward the hemidesmosomal proteins BP230 and BP180. Development of an IgG passive transfer mouse model of BP that reproduces these key features of human BP has demonstrated that subepidermal blistering is initiated by anti-BP180 antibodies and mediated by complement activation, mast cell degranulation, neutrophil infiltration, and proteinase secretion. This model is not compatible with study of human pathogenic antibodies, as the human and murine antigenic epitopes are not cross-reactive. The development of two novel humanized mouse models for the first time has enabled study of disease mechanisms caused by BP autoantibodies, and presents an ideal in vivo system to test novel therapeutic strategies for disease management.
Brouillard - Livre de Frick, Gipf, Wittnau, Oeschgen, Hornussen, etc., No. 6
Creators: name: Perrollaz, Cartier & Co
Publisher: name: [s.n.]
Year: 1817

description: Darin: Register, lose Einlage in separatem Umschlag
description: Französisch
description: Verzeichnung=Description=Inventaire 2014 ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Sebastian Preher
Distance to Diagnosing Provider as a Measure of Access for Patients With Melanoma
Creators: name: Berwick, Marianne
name: Mattingly, Dianne
name: Dalton, Kathleen
name: Stitzenberg, Karyn B.
name: Millikan, Robert C.
name: Brier, Sarah E.
name: Thomas, Nancy E.
name: Ollila, David W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: To examine the effect of travel distance and other sociodemographic factors on access to a diagnosing provider for patients with melanoma.
Long-range order and pinning of charge-density waves in competition with superconductivity
Creators: name: Caplan, Yosef
name: Wachtel, Gideon
name: Orgad, Dror
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Recent experiments show that charge-density-wave correlations are prevalent in underdoped cuprate superconductors. The correlations are short ranged at weak magnetic fields but their intensity and spatial extent increase rapidly at low temperatures beyond a crossover field. Here we consider the possibility of long-range charge-density-wave order in a model of a layered system where such order competes with superconductivity.We show that in the clean limit, low-temperature long-range order is stabilized by arbitrarily weak magnetic fields. This apparent discrepancy with the experiments is resolved by the presence of disorder. Like the field, disorder nucleates halos of charge-density wave, but unlike the former it also disrupts interhalo coherence, leading to a correlation length that is always finite. Our results are compatible with various experimental trends, including the onset of longer range correlations induced by interlayer coupling above a characteristic field scale.
description: 13 pages, including appendices
Holistic engineering approach to increase sensitivity of a miniaturised fluorescence detector for POCT systems
Creators: name: Robbins, Hannah
Publisher: name: Figshare
Year: 2019
Subjects: subject: 91399 Mechanical Engineering not elsewhere classified
subject: FOS: Mechanical engineering

description: The demand for rapid in vitro diagnosis (IVD) point-of-care testing (POCT) systems to be used outside of a traditional healthcare setting has been vastly expanding. Effective fabrication solutions need to be forward thought to satisfy miniaturized and heterogeneously integrated POCT. A holistic engineering approach to increase sensitivity of a miniaturised fluorescence detector for POCT systems was carried out. The study investigated how effective fabrication methods could deliver a better performance fluorescence detector (FD) to be well fitted in sophisticated and varying POCT systems. SLA and SLS were introduced in the study and evaluated through the measurement of surface texture of roughness with an Alicona Infinite Focus instrument. SLA was ultimately selected to produce a functional OFD through the validation with a selected fluorescence dye, i.e., Cy5. A limit of detection was reached of 1.209x10-10 Mol to reach a certain level of IVD detection. In addition to this anisotropic wet etching was investigated as a portal into the development of miniaturised integration microfluidic FD. A case study was performed to compare the sensitivity of the FD’s design, manufactured and tested against another style of FD.  The work creates an avenue of rapid screening POCT OFD fabrication solutions with a view on high performance and multi-functional detection systems not only in POCT, but also high-throughput (HTP) screening in life sciences and environmental applications.
Prediction of drivers’ performance in highly automated vehicles
Creators: name: Alrefaie, Mohamed
Publisher: name: Figshare
Year: 2019
Subjects: subject: 150399 Business and Management not elsewhere classified
subject: FOS: Economics and business

description: Purpose:  The aim of this research was to assess the predictability of driver’s response to critical hazards during the transition from automated to manual driving in highly automated vehicles using their physiological data.Method: A driving simulator experiment was conducted to collect drivers’ physiological data before, during and after the transition from automated to manual driving. A total of 33 participants between 20 and 30 years old were recruited. Participants went through a driving scenario under the influence of different non-driving related tasks. The repeated measures approach was used to assess the effect of repeatability on the driver’s physiological data. Statistical and machine learning methods were used to assess the predictability of drivers’ response quality based on their physiological data collected before responding to a critical hazard. Findings: - The results showed that the observed physiological data that was gathered before the transition formed strong indicators of the drivers’ ability to respond successfully to a potential hazard after the transition. In addition, physiological behaviour was influenced by driver’s secondary tasks engagement and correlated with the driver’s subjective measures to the difficulty of the task. The study proposes new quality measures to assess the driver’s response to critical hazards in highly automated driving. Machine learning results showed that response time is predictable using regression methods. In addition, the classification methods were able to classify drivers into low, medium and high-risk groups based on their quality measures values.  Research Implications: Proposed models help increase the safety of automated driving systems by providing insights into the drivers’ ability to respond to future critical hazards. More research is required to find the influence of age, drivers’ experience of the automated vehicles and traffic density on the stability of the proposed models. Originality: The main contribution to knowledge of this study is the feasibility of predicting drivers’ ability to respond to critical hazards using the physiological behavioural data collected before the transition from automated to manual driving. With the findings, automation systems could change the transition time based on the driver’s physiological state to allow for the safest transition possible. In addition, it provides an insight into driver’s readiness and therefore, allows the automated system to adopt the correct driving strategy and plan to enhance drivers experience and make the transition phase safer for everyone.
Metabolic response to carnitine in methylmalonic aciduria. An effective strategy for elimination of propionyl groups.
Creators: name: Hoppel, C L
name: Tracey, B M
name: Chalmers, R A
name: Stacey, T E
name: Millington, D S
name: Roe, C R
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1983

description: Observation clinique et biologique d'une fille actuellement âgée de 21 mois, atteinte d'acidurie méthylmalonique. Les effets de l'administration de carnitine sont analysés. Elle agit par élimination (détoxification) des groupes propionyl, libérant ainsi le CoA et normalisant la biosynthèse et les taux d'ATP. Elle peut jouer un rôle central pour le maintien de l'homéostasie mitochondriale et cellulaire dans les acidémies méthylmalonique et propionique et représenter un espoir pour d'autres affections héréditaires ou acquises.
BCG and prevention of tuberculous meningitis.
Creators: name: Runyan, D K
name: Banu, K
name: Thilothammal, N
name: Krishnamurthy, P V
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: The reported efficacy of BCG vaccine in preventing pulmonary tuberculosis varies from 0-80% ; however, its efficacy in preventing tuberculous meningitis ranges from 52%-84%. A case-control study was conducted to assess the efficacy of BCG in preventing tuberculous meningitis in children. New cases of tuberculous meningitis, confirmed bacteriologically, were registered as cases. Controls were children suffering from febrile convulsions attending the same hospital. A total of 107 cases and 321 controls, block matched for age, were registered. Vaccination status was determined from the history reported by the mother and by BCG scar reading. Data regarding socioeconomic status, crowding, and nutritional status were collected. Using multiple logistic regression analysis the odds ratio obtained for the presence of BCG scar was 0.23 (95% confidence interval (CI) 0.14 to 0.37) and the protective efficacy of BCG vaccine in preventing tuberculous meningitis in children was found to be 77% (95% CI 71 to 83%).
Topological p-n junctions in helical edge states
Creators: name: Wadhawan, Disha
name: Mehta, Poonam
name: Das, Sourin
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum spin Hall effect is endowed with topologically protected edge modes with gapless Dirac spectrum. Applying a magnetic field locally along the edge leads to a gapped edge spectrum with opposite parity for winding of spin texture for conduction and valence band. Using Pancharatnam's prescription for geometric phase it is shown that mismatch of this parity across a $p$-$n$ junction, which could be engineered into the edge by electrical gate induced doping, leads to a phase dependence in the two-terminal conductance which is purely topological (0 or $π$). This fact results in a ${\mathbb{Z}}_2$ classification of such junctions with an associated duality. Current asymmetry measurements which are shown to be robust against electron-electron interactions are proposed to infer this topology.
description: revised version: v2 with supplementary material added
Additional file 7 of A promising resilience parameter for breeding: the use of weight and feed trajectories in growing pigs
Creators: name: Gorssen, Wim
name: Winters, Carmen
name: Meyermans, Roel
name: Chapard, Léa
name: Hooyberghs, Katrijn
name: Janssens, Steven
name: Huisman, Abe
name: Peeters, Katrijn
name: Mulder, Han
name: Buys, Nadine
Publisher: name: figshare
Year: 2023
Subjects: subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: Additional file 7: Fig. S4. Pairwise correlation plots for all evaluated traits with full datasets and reduced datasets.
A novel strategy to reveal the landscape of sex-specific crossover rate and interference in an F1 hybrid population of Populus deltoides and Populus simonii
Creators: name: Li, Zhiting
name: Zhao, Wei
name: Zhang, Jinpeng
name: Pan, Zhiliang
name: Bai, Shengjun
name: Tong, Chunfa
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: 60408 Genomics

description: Supplementary Table S1 (SuppFile1.xlsx) The RADseq data information for the 2 parents and 257 progeny in the F1 hybrid population of Populus deltoides and Populus simonii.
 Supplementary Appendix A (SuppFile2.pdf) Calculation of the coefficient of coincidence between the two adjacent SNP intervals for the female parent in an F1 population of Populus deltoides and Populus simonii
Fetal homologue of infant crying
Creators: name: Gingras, J L
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: Four behavioural states are recognised in the human fetus and are comparable to those of the neonate: 1F (quiet sleep), 2F (active state), 3F (quiet awake), and 4F (active awake). State 5, or crying, is not considered to have a fetal correlate. In a study assessing the effects of exposure to tobacco and cocaine during pregnancy on fetal response and habituation to vibroacoustic stimulation, what appears to be the fetal homologue of crying was observed. These behaviours were seen on ultrasound, and have been captured on video recordings and include: an initial exhalation movement associated with mouth opening and tongue depression, followed by a series of three augmented breaths, the last breath ending in an inspiratory pause followed by an expiration and settling. This is the first report/video documenting these behaviours and suggests the possibility of a state 5F.
Understanding wrist splint user needs and personalisation through codesign
Creators: name: Pyatt, Charlotte
Publisher: name: Figshare
Year: 2019
Subjects: subject: 120399 Design Practice and Management not elsewhere classified
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: Wrist splints are a common treatment for rheumatoid arthritis, however their effectiveness is compromised by patients not wearing splints as often as prescribed. Previous research has identified a number of reasons for non-compliance, but typically lacks insights that could lead to improved splint design.This thesis investigates the motivators for patients to wear and not wear their wrist splints and, the impact of personalisation of splint appearance on patient wear. The work is based on the premise that digital design and manufacturing processes, such as Computer-Aided Design (CAD) and 3D Printing, can produce bespoke splints on demand.The research begins with a literature review across the core areas of: splinting, additive manufacture, product appearance and personalisation. This literature review identifies gaps in knowledge from which research questions are established for the work.The research employs a qualitative, generative design research approach and, follows a codesign framework employing telling, making and enacting tools. The thesis is made up of three studies. The first study is a sensitisation study and uses design probes to prepare the participants for the research and begin exploring the problem space. The second is a comprehensive study into participants splint wear behaviour and uses context mapping and scenario picture card tools to investigate the motivators for participants to wear and not wear wrist splints, along with positive and negative outcomes or wearing/not wearing splints. The final study uses a personalisation toolkit to elicit patient needs for a future wrist splint design and investigate self-reported expectations regarding compliance of patients who used the toolkit.The research finds that patient compliance is affected by practical and aesthetic limitations of current splints. It identifies 4 motivating factors to wear a splint and 10 motivating factors to not wear a splint. Additionally, it identifies 6 positive outcomes of wearing splints, 6 negative outcomes of wearing splints, 3 positive outcomes of not wearing splints and 3 negative outcomes of not wearing splints. Requirements for an improved splint design are established and form the basis of the design for a prototype personalisation toolkit. Testing of this toolkit reveals that patients are keen to own more than one splint and personalise splints to match the scenario in which it is to be worn. Patients reported that they expected to be more compliant with a personalised splint when compared to their current splint.
Patent ductus arteriosus: lack of evidence for common treatments
Creators: name: Bose, C. L
name: Laughon, M. M
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Patent ductus arteriosus (PDA) is a common diagnosis among extremely premature infants, especially in those with lung disease. Treatments are often used to close the PDA. Despite nearly three decades of research, the question of whether the benefits of treatments to prevent ductal patency or promote closure outweigh the risks of these treatments remains unanswered. The authors rarely use treatments designed to close the PDA. This article reviews three considerations in support of this restrained approach: rates of spontaneous closure of the ductus arteriosus; adverse effect of persistent ductal patency; and benefits and risks of treatments for closure.
Additional file 1 of Clinical and life style factors related to the nighttime blood pressure, nighttime dipping and their phenotypes in Korean hypertensive patients
Creators: name: Kim, Byung Sik
name: Kim, Ju Han
name: Kim, Wan
name: Kim, Woo Shik
name: Park, Sungha
name: Lee, Sang Jae
name: Kim, Jang Young
name: Lee, Eun Mi
name: Ihm, Sang Hyun
name: Pyun, Wook Bum
name: Shin, Jeong-Hun
name: Shin, Jinho
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1: Table S1. Additional multiple linear regression analysis performed by excluding 24-hour mean SBP and Office SBP for the factor associated with extent of nighttime systolic blood pressure dipping in hypertensive patients. Table S2. Blood pressure patterns according to the different definitions of nighttime blood pressure. Table S3. Comparisons of the proportion of dipping patterns according to the different definitions of nighttime blood pressure. Table S4. Multiple logistic regression analysis for the factors associated with nighttime dipping less than 10 percent in hypertensive patients according to the different definitions of nighttime blood pressure.