cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Strand breakage by decay of DNA-bound 124I provides a basis for combined PET imaging and Auger endoradiotherapy
Creators: name: Lobachevsky, Pavel
name: Clark, George R.
name: Pytel, Patrycja D.
name: Leung, Brenda
name: Skene, Colin
name: Andrau, Laura
name: White, Jonathan M.
name: Karagiannis, Tom
name: Cullinane, Carleen
name: Boon Q. Lee
name: Stuchbery, Andrew
name: Kibedi, Tibor
name: Hicks, Rodney J.
name: Martin, Roger F.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: Purpose DNA ligands labelled with 125I induce cytotoxic DNA double-strand breaks (DSB), suggesting a potential for Auger endoradiotherapy. Since the 60-day half-life of 125I is suboptimal for therapy, we have investigated another Auger-emitter 124I, with shorter half-life (4.18 days), and the additional feature of positron-emission, enabling positron emission tomography (PET) imaging. The purpose of this study was to compare the two radionuclides on the basis of DNA DSB per decay. Materials and methods Using a 124I- (or 125I)-labelled minor groove binding DNA ligand, we investigated DNA breakage using the plasmid DNA assay. Biodistribution of the conjugate of the labelled ligand with transferrin was investigated in nude mice bearing a K562 human lymphoma xenograft. Results The probability of DSB per decay was 0.58 and 0.85 for 124I and 125I, respectively, confirming the therapeutic potential of the former. The crystal structure of the ligand DNA complex shows the iodine atom deep within the minor groove, consistent with the high efficiency of induced damage. Biodistribution studies, including PET imaging, showed distinctive results for the conjugate, compared to the free ligand and transferrin, consistent with receptor-mediated delivery of the ligand. Conclusions Conjugation of 124I-labelled DNA ligands to tumor targeting peptides provides a feasible strategy for Auger endoradiotherapy, with the advantage of monitoring tumor targeting by PET imaging.
Assessing causes of quality deterioration of groundwater in Puttalam, Sri Lanka, using isotope and hydrochemical tools†
Creators: name: E. A. N. V. Edirisinghe
name: G. R. R. Karunarathne
name: A. S. M. N. B. Samarakoon
name: H. M. T. G. A. Pitawala
name: H. A. Dharmagunawardhane
name: I. A. N. D. P. Tilakarathna
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: Science Policy

description: Extensive extraction of groundwater has resulted in deterioration of the groundwater quality in the Puttalam area in the northwestern coastal zone of Sri Lanka. This situation led us to carry out the present comprehensive study based on environmental isotopic (18O, 2H, 3H) and geochemical evaluation to understand the root cause for water quality deterioration. The isotopic data suggest that the surface water and shallow groundwaters are subjected to intensive evaporation and, as a result, increase in their salinity. Deep groundwater of the area is mostly recharged by direct infiltration of rainwater and at few places by nearby surface water bodies. The salinity increase of deep groundwater depends on the specific hydrogeological zones and would be due to dissolution of salts which are precipitated in soil through the seawater spray over the time, dissolution of minerals in geological matrix and leaching of salts from salterns. The quality of the deep groundwater is relatively good in the granitic gneiss zone and nearby areas outside the sedimentary aquifer. There is no evidence from isotope and hydrogeochemical evaluation for seawater intrusion into groundwater in the Puttalam area.
Assessing causes of quality deterioration of groundwater in Puttalam, Sri Lanka, using isotope and hydrochemical tools
Creators: name: E. A. N. V. Edirisinghe
name: G. R. R. Karunarathne
name: A. S. M. N. B. Samarakoon
name: H. M. T. G. A. Pitawala
name: H. A. Dharmagunawardhane
name: I. A. N. D. P. Tilakarathna
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: Science Policy

description: Extensive extraction of groundwater has resulted in deterioration of the groundwater quality in the Puttalam area in the northwestern coastal zone of Sri Lanka. This situation led us to carry out the present comprehensive study based on environmental isotopic (18O, 2H, 3H) and geochemical evaluation to understand the root cause for water quality deterioration. The isotopic data suggest that the surface water and shallow groundwaters are subjected to intensive evaporation and, as a result, increase in their salinity. Deep groundwater of the area is mostly recharged by direct infiltration of rainwater and at few places by nearby surface water bodies. The salinity increase of deep groundwater depends on the specific hydrogeological zones and would be due to dissolution of salts which are precipitated in soil through the seawater spray over the time, dissolution of minerals in geological matrix and leaching of salts from salterns. The quality of the deep groundwater is relatively good in the granitic gneiss zone and nearby areas outside the sedimentary aquifer. There is no evidence from isotope and hydrogeochemical evaluation for seawater intrusion into groundwater in the Puttalam area.
EuroMED Cooperation. Inland and Marine Water Challenges
Creators: name: CNR DTA-Dipartimento Terra E Ambiente
Publisher: name: figshare
Year: 2016
Subjects: subject: 160511 Research, Science and Technology Policy
subject: FOS: Political science

description: EUROMED COOPERATION. INLAND AND MARINEWATER CHALLENGESNaples Conference report
When free is not enough: what the International Librarians Network managed to achieve with zero budget, and what we did when we hit the limits.
Creators: name: Dalby, Alyson
name: Barker, Amy
name: Byrne, Kate
name: McKenzie, Clare
Publisher: name: figshare
Year: 2016
Subjects: subject: Library and Information Studies
subject: FOS: Media and communications

description: The International Librarians Network (ILN) began as a way to help librarians develop an international professional network without having to travel overseas. Focusing on openness and relying entirely on freely available technology and volunteer time, the program was designed to reinforce the idea that ideas can cross borders and make us better at what we do. The ILN launched in 2013, free and open to anyone in the profession, and has facilitated connections for over 1500 people in 103 countries. Unfunded and completely independent, the ILN was established using a suite of freely available technology to create and maintain an online profile. This included Gmail, Google Drive, Google Forms, Dropbox, Wordpress, Twitter, Facebook and AnyMeeting. In the development stage of the program these tools were sufficient, and their ease of use allowed the ILN founders to focus on the content and rapid development of the program, rather than requiring advanced technical skills. Combined with a network of volunteers, the ILN was able to have a positive impact on librarians around the world. By early 2014, with the rapid growth of the program, the no-cost model that had served the ILN well started to hinder the growth of the program. As additional time was being spent to find and implement work-arounds to technical limitations, the ILN realised that free was no longer enough. The program needed to move beyond the limitation of free web-based tools and an informal business structure, but there was still no budget to do so. Early efforts to identify pathways forward were hampered by financial restrictions, a lack of transparency by service providers, and a confusing abundance of small scale commercial providers of services. This paper will outline how the ILN used freely available technology to establish and grow, and what was achieved from this base. The paper will then explore the steps the ILN took to identify planning and development strategies for small organisations and projects that need to ‘do more with less’. It will pragmatically explore the limitations of ‘free’ and what to do when free is not enough, and show the role that small-scale strategic planning can play in helping small organisations or projects manage growth in a scalable and sustainable way.
title: 01_1377
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
title: ÐÑÐ¾ÑÐ°Ñ Ð½Ð¸ÑÐºÐ° ÑÐ»ÑÐ·Ð° Ð² ÑÐ¾ÑÑÐ°Ð²Ðµ Ð½Ð¸Ð·ÐºÐ¾Ð½Ð°Ð¿Ð¾ÑÐ½Ð¾Ð³Ð¾ Ð³Ð¸Ð´ÑÐ¾ÑÐ·Ð»Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: The second thread of the gateway as part of a low-pressure hydroelectric power unit
Creators: name: ÐÐ¾ÑÐ¾Ð½Ð¸Ð½Ð°, ÐÐ»Ð¸Ð·Ð°Ð²ÐµÑÐ°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2023
Subjects: Ð¨Ð»ÑÐ·Ñ ÑÑÐ´Ð¾Ñ Ð¾Ð´Ð½ÑÐµ
ÑÐ»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ðµ
Ð³Ð¸Ð´ÑÐ¾ÑÐ·ÐµÐ»
sluicing
hydroelectric power unit

description: Ð ÑÐ°Ð±Ð¾ÑÐµ Ð¿ÑÐµÐ´Ð»Ð¾Ð¶ÐµÐ½Ð¾ ÑÐµÑÐµÐ½Ð¸Ðµ Ð¿ÑÐ¾Ð±Ð»ÐµÐ¼Ñ Ð½ÐµÐ´Ð¾ÑÑÐ°ÑÐ¾ÑÐ½Ð¾Ð¹ Ð¿ÑÐ¾Ð¿ÑÑÐºÐ½Ð¾Ð¹ ÑÐ¿Ð¾ÑÐ¾Ð±Ð½Ð¾ÑÑÐ¸ ÑÐ»ÑÐ·Ð° Ð² ÑÐ¾ÑÑÐ°Ð²Ðµ Ð½Ð¸Ð·ÐºÐ¾Ð½Ð°Ð¿Ð¾ÑÐ½Ð¾Ð³Ð¾ Ð³Ð¸Ð´ÑÐ¾ÑÐ·Ð»Ð° Ð¿Ð¾ÑÑÐµÐ´ÑÑÐ²Ð¾Ð¼ Ð¿ÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð²ÑÐ¾ÑÐ¾Ð¹ Ð½Ð¸ÑÐºÐ¸ ÑÐ»ÑÐ·Ð°. Ð Ð¿ÑÐ¾ÑÐµÑÑÐµ Ð²ÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð¸Ñ Ð²ÑÐ¿ÑÑÐºÐ½Ð¾Ð¹ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ ÑÐµÑÐµÐ½Ñ ÑÐ»ÐµÐ´ÑÑÑÐ¸Ðµ Ð·Ð°Ð´Ð°ÑÐ¸: - Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ðµ ÑÑÐ²Ð¾ÑÐ° Ð²ÑÐ¾ÑÐ¾Ð¹ Ð½Ð¸ÑÐºÐ¸ ÑÐ»ÑÐ·Ð°; - Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ðµ ÐºÐ¾Ð½ÑÑÑÑÐºÑÐ¸Ð¸ ÑÐ»ÑÐ·Ð°, Ð° ÑÐ°ÐºÐ¶Ðµ ÐµÐ³Ð¾ Ð³Ð°Ð±Ð°ÑÐ¸ÑÐ¾Ð²; - ÑÐ°ÑÑÐµÑ Ð¿ÑÐ¾Ð¿ÑÑÐºÐ½Ð¾Ð¹ ÑÐ¿Ð¾ÑÐ¾Ð±Ð½Ð¾ÑÑÐ¸ Ð²ÑÐ¾ÑÐ¾Ð¹ Ð½Ð¸ÑÐºÐ¸ ÑÐ»ÑÐ·Ð°; - ÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð²ÑÐ²Ð¾Ð´Ð¾Ð². Ð ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐµ ÑÐ°Ð±Ð¾ÑÑ Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÐµÐ½Ñ ÐºÐ¾Ð½ÑÑÑÑÐºÑÐ¸Ð²Ð½ÑÐµ ÑÐµÑÐµÐ½Ð¸Ñ Ð²ÑÐ¾ÑÐ¾Ð¹ Ð½Ð¸ÑÐºÐ¸ ÑÐ»ÑÐ·Ð°, ÑÐ°ÐºÐ¶Ðµ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð° Ð¿ÑÐ¾Ð¿ÑÑÐºÐ½Ð°Ñ ÑÐ¿Ð¾ÑÐ¾Ð±Ð½Ð¾ÑÑÑ ÑÐ»ÑÐ·Ð°. Ð¡ÑÑÐ¾Ð¸ÑÐµÐ»ÑÑÑÐ²Ð¾ Ð²ÑÐ¾ÑÐ¾Ð¹ Ð½Ð¸ÑÐºÐ¸ ÑÐ»ÑÐ·Ð° Ð·Ð½Ð°ÑÐ¸ÑÐµÐ»ÑÐ½Ð¾ ÑÐ²ÐµÐ»Ð¸ÑÐ¸Ñ ÑÑÐ´Ð¾Ð¿ÑÐ¾Ð¿ÑÑÐº ÑÐµÑÐµÐ· ÑÐ¾Ð¾ÑÑÐ¶ÐµÐ½Ð¸Ñ Ð³Ð¸Ð´ÑÐ¾ÑÐ·Ð»Ð°.
description: The paper proposes a solution to the problem of insufficient capacity of the gateway as part of a low-pressure hydraulic unit by designing the second thread of the gateway. In the process of completing the final qualification work , the following tasks were solved: - determination of the gate of the second thread of the gateway; - determination of the gateway design, as well as its dimensions; - calculation of the throughput of the second gateway line; - forming conclusions. As a result of the work, the design solutions of the second thread of the gateway are presented, and the throughput of the gateway is also determined. The construction of the second line of the gateway will significantly increase the ships passage through the waterworks.
DTA/16-2013 - Ny-Ålesund Science Managers Committee NySMAC 11th Seminar - Abstracts
Creators: name: CNR DTA-Dipartimento Terra E Ambiente
Publisher: name: figshare
Year: 2016
Subjects: subject: 160511 Research, Science and Technology Policy
subject: FOS: Political science

description: The seminar brings together scientists who have Svalbard and Ny-Ålesund (78°55’N, 11°56’E) in particular as a base for their research and monitoring activities. The aim of the meeting is to exchange scientific results, advancements, ideas and experiences to inspire each other and develop Ny-Ålesund further.The seminar wants to foster the following topics: Flagship programs, SSF funded projects, Implementation of Ny-Ålesund monitoring activities, NySMAC and SIOS: Status and future developments.
DALIA Knowledge-Base: Der Community-Hub für FAIRe Datenbereitstellung und Datennutzung
Creators: name: Hastik, Canan
name: Herres-Pawlis, Sonja
name: Pelz, Peter F.
name: Ulrich, Sax
name: Schrade, Torsten
name: Stäcker, Thomas
name: Kismihók, Gábor
name: Müller, Matthias
Publisher: name: Zenodo
Year: 2023

description: Das Verbundprojekt DALIA folgt dem Paradigma “Datenkompetenz von Anfang an”. Damit wird die Bildung und Stärkung dieser Schlüsselqualifikation betont und ein Bogen von der Datennutzung bis zur Datenbereitstellung gespannt. Mit DALIA wird der Forschungscommunity ein neuartiger Wissens-Hub für Lehr- und Lernmaterialien zur Verfügung gestellt und dauerhaft etabliert. Gleichzeitig werden wissenschaftliche, politische, rechtliche und wirtschaftliche Fragen nach dem Wert von Daten, der Datenökonomie, sozialen Regeln im Umgang mit Daten, Aspekten des Eigentums- und Persönlichkeitsrechts und der Vermittlung adressiert.

DALIA steht für “Data  Literacy Alliance”. Diese verbindet ein disziplinübergreifendes Kompetenzspektrum aus Lehre, Forschung, Infrastruktur und Wissensmanagement getragen von Prof. Peter Pelz, Prof. Sonja Herres-Pawlis, Prof. Ulrich Sax, Prof. Torsten Schrade und Prof. Thomas Stäcker, Prof. Mathias Müller und Dr. Gabor Kishmihok. Über die enge Verbundenheit der Projektpartner mit dem NFDI e.V. und den Sektionen Training & Education, ELSA Ethical, Legal & Social Aspects und (Meta)daten, Terminologien, Provenienz wird sichergestellt, dass nach dem Projekt Lern- und Lehrmaterialien über die Knowledge-Base kontinuierlich angeboten werden und bedarfsorientiert eine methodisch-technische Weiterentwicklung der Knowledge-Base stattfindet.

Es wird davon ausgegangen, dass die Bedarfe der NutzerInnen und AnbieterInnen von Lern- und Lehrmaterialien vielfältig sind, sich nach Kompetenz- und Karrierestufen spezifizieren, differenzieren, verändern und wachsen. Um die unterschiedlichen Bedarfe aller Karriere- und Kompetenzstufen und Disziplinen zu vernetzen und zu integrieren, wird in DALIA ein Wissensgraph mit Such- und Empfehlungsdiensten entwickelt, der offen und interoperabel ist und als föderiertes Vernetzungssystem externe Ressourcen anschlussfähig und zugänglich macht. Über die Anbindung verteilter Quellen lernt die Systemlogik, die den Lernprozess durch individuelle Lernpfade, dynamische Lernempfehlungen, Such- und Filteroptionen, Personalisierung, Qualitätssicherungsprozess, Monitoring, Bewertungen und Reviews unterstützt. Zielgruppenorientierung, Qualitätssicherung und Stand der Technik bilden die kommunikative Brücke zwischen Bedarfen, Materialien und Disziplinen und sind die Grundlage für DALIA mit dem Funktionsumfang um FAIRes Forschungsdatenmanagement und Data Science nachhaltig und ganzheitlich zu fördern und disziplinübergreifend zu verankern.

 
description: This project with the funding code 16DWWQP07A, 16DWWQP07B, 16DWWQP07C, 16DWWQP07D,  and 16DWWQP07E was funded by the Federal Ministry of Education and Research (BMBF) and the funding measure from the EU’s Capacity Building and Resilience Facility.
Fitting probability distributions to economic growth: a maximum likelihood approach
Creators: name: Hassan, Mahmood Ul
name: Stockhammar, Pär
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Plant Biology

description: The growth rate of the gross domestic product (GDP) usually carries heteroscedasticity, asymmetry and fat-tails. In this study three important and significantly heteroscedastic GDP series are examined. A Normal, normal-mixture, normal-asymmetric Laplace distribution and a Student's t-Asymmetric Laplace (TAL) distribution mixture are considered for distributional fit comparison of GDP growth series after removing heteroscedasticity. The parameters of the distributions have been estimated using maximum likelihood method. Based on the results of different accuracy measures, goodness-of-fit tests and plots, we find out that in the case of asymmetric, heteroscedastic and highly leptokurtic data the TAL-distribution fits better than the alternatives. In the case of asymmetric, heteroscedastic but less leptokurtic data the NM fit is superior. Furthermore, a simulation study has been carried out to obtain standard errors for the estimated parameters. The results of this study might be used in e.g. density forecasting of GDP growth series or to compare different economies.
title: Secure device-to-device communication for emergency response
Creators: name: Álvarez, Flor
Publisher: name: UNSPECIFIED
Year: 2020

description: Mobile devices have the potential to make a significant impact during disasters. However, their practical impact is severely limited by the loss of access to mobile communication infrastructure: Precisely, when there is a surge in demand for communications from people in a disaster zone, this capacity for communications is severely curtailed. This loss of communications undermines the effectiveness of the many recent innovations in the use of smartphones and similar devices to mitigate the effects of disasters. While various solutions have been proposed, e. g., by having handsets form wireless ad hoc networks, none are complete: Some are specific to certain mobile operating systems or operating system versions. Others result in unacceptably increased energy consumption, flattening the batteries of phones at a time when users need to conserve energy due to the loss of access to opportunities to recharge their mobile devices. Realistic user behaviour, including patterns of movement and communications, are also rarely addressed. Further, security is rarely considered in a comprehensive and satisfying manner, leaving users exposed to a variety of potential attacks. Thus there is a compelling need to find more effective solutions for communications, energy management, and security of mobile devices operating in disaster conditions. To address these shortcomings, this thesis provides a suite of comprehensive solutions that contribute to facilitate secure device-to-device communication for emergency response. This thesis works to solve these problems by: (i) Conducting a large-scale field-trial to understand and analyze civilians’ behaviour during disaster scenarios; (ii) Proposing a practical, lightweight scheme for bootstrapping device-to-device security, that is tailored for local urban operations representative of disaster scenarios; (iii) Realizing novel energy management strategies for the neighbour discovery problem, which deliver significant energy savings in return for only a minimal reduction in neighbour discovery efficiency; (iv) The description of novel concepts for using devices in a smart city environment that remain functional following a disaster to support communications among mobile devices. In short, this thesis adds considerably to the understanding of the difficulties in the formation of direct device-to-device communications networks composed primarily of civilians’ mobile devices, and how several facets of this problem can be mitigated. Several of the proposed enhancements are also implemented. Thus, this thesis also takes essential steps in the direction of realizing such solutions to demonstrate their feasibility on real devices, intending to improve the tools available to civilians post-disaster.
The effects of water and dairy drinks on dietary patterns in overweight adolescents
Creators: name: Andersen, Louise B. B.
name: Arnberg, Karina
name: Trolle, Ellen
name: Michaelsen, Kim F.
name: Bro, Rasmus
name: Pipper, Christian B.
name: Mølgaard, Christian
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Computational Biology

description: The aim was to investigate the effects of increased water or dairy intake on total intake of energy, nutrients, foods and dietary patterns in overweight adolescents in the Milk Components and Metabolic Syndrome (MoMS) study (n= 173). Participants were randomly assigned to consume 1l/d of skim milk, whey, casein or water for 12 weeks. A decrease in the dietary pattern called Convenience Food, identified by principal component analysis, was observed during the intervention both in the water and dairy groups. Total energy intake decreased by 990.9 kJ/d (236.8 kcal/d) in the water group but was unchanged in the dairy group during intervention. To conclude, an extra intake of fluid seems to favourably affect the rest of the diet by decreasing the intake of convenience foods, including sugar-sweetened beverages. A low energy drink, such as water, seems advantageous considering the total energy intake in these overweight adolescents. This study is registered at clinicaltrials.gov (NCT00785499).
BAG3 regulates total MAP1LC3B protein levels through a translational but not transcriptional mechanism
Creators: name: Rodríguez, Andrea E.
name: López-Crisosto, Camila
name: Peña-Oyarzún, Daniel
name: Salas, Daniela
name: Parra, Valentina
name: Quiroga, Clara
name: Morawe, Tobias
name: Chiong, Mario
name: Behl, Christian
name: Lavandero, Sergio
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Cancer
subject: Plant Biology
subject: Computational Biology

description: Autophagy is mainly regulated by post-translational and lipid modifications of ATG proteins. In some scenarios, the induction of autophagy is accompanied by increased levels of certain ATG mRNAs such as MAP1LC3B/LC3B, ATG5 or ATG12. However, little is known about the regulation of ATG protein synthesis at the translational level. The cochaperone of the HSP70 system BAG3 (BCL2-associated athanogene 3) has been associated to LC3B lipidation through an unknown mechanism. In the present work, we studied how BAG3 controls autophagy in HeLa and HEK293 cells. Our results showed that BAG3 regulates the basal amount of total cellular LC3B protein by controlling its mRNA translation. This effect was apparently specific to LC3B because other ATG protein levels were not affected. BAG3 knockdown did not affect LC3B lipidation induced by nutrient deprivation or proteasome inhibition. We concluded that BAG3 maintains the basal amount of LC3B protein by controlling the translation of its mRNA in HeLa and HEK293 cells.
Allgemeine Lorentztransformationen und die Gleichzeitigkeit
Creators: name: Schröer, Harald
Publisher: name: Zenodo
Year: 2015
Subjects: lorentz,transformation,general,relativistic,special,speed,velocity

description: Es wird gezeigt, daß 3 Formeln zu allgemeinen Lorentztransformationen gleichwertig sind. Die speziellen Lorentztransfomationen werden gefolgert. Außerdem wird die allgemeine relativistische Gleichzeitigkeit betrachtet.
description: German
Differing susceptibility to autophagic degradation of two LC3-binding proteins: SQSTM1/p62 and TBC1D25/OATL1
Creators: name: Hirano, Satoshi
name: Uemura, Takefumi
name: Annoh, Hiromichi
name: Naonobu Fujita
name: Waguri, Satoshi
name: Itoh, Takashi
name: Fukuda, Mitsunori
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: MAP1LC3/LC3 (a mammalian ortholog family of yeast Atg8) is a ubiquitin-like protein that is essential for autophagosome formation. LC3 is conjugated to phosphatidylethanolamine on phagophores and ends up distributed both inside and outside the autophagosome membrane. One of the well-known functions of LC3 is as a binding partner for receptor proteins, which target polyubiquitinated organelles and proteins to the phagophore through direct interaction with LC3 in selective autophagy, and their LC3-binding ability is essential for degradation of the polyubiquitinated substances. Although a number of LC3-binding proteins have been identified, it is unknown whether they are substrates of autophagy or how their interaction with LC3 is regulated. We previously showed that one LC3-binding protein, TBC1D25/OATL1, plays an inhibitory role in the maturation step of autophagosomes and that this function depends on its binding to LC3. Interestingly, TBC1D25 seems not to be a substrate of autophagy, despite being present on the phagophore. In this study we investigated the molecular basis for the escape of TBC1D25 from autophagic degradation by performing a chimeric analysis between TBC1D25 and SQSTM1/p62 (sequestosome 1), and the results showed that mutant TBC1D25 with an intact LC3-binding site can become an autophagic substrate when TBC1D25 is forcibly oligomerized. In addition, an ultrastructural analysis showed that TBC1D25 is mainly localized outside autophagosomes, whereas an oligomerized TBC1D25 mutant rather uniformly resides both inside and outside the autophagosomes. Our findings indicate that oligomerization is a key factor in the degradation of LC3-binding proteins and suggest that lack of oligomerization ability of TBC1D25 results in its asymmetric localization at the outer autophagosome membrane.
title: Realtime Vehicle Route Optimisation via DQN for Sustainable and Resilient Urban Transportation Network
Creators: name: Koh, SS
Publisher: name: Liverpool John Moores University
Year: 2022

description: Traffic congestion has become one of the most serious contemporary city issues for urban transportation network as it leads to unnecessary high energy consumption, air pollution and extra travelling time. During this decade, many optimization algorithms have been designed to achieve the optimal usage of existing roadway capacity in cities to leverage the problem. However, it is still a challenging task for the vehicles to interact with the complex city environment in a real time manner. In this thesis, we propose a deep reinforcement learning (DRL) method to build a real-time intelligent vehicle navigation system for sustainable and resilient urban transportation network. We designed two rewards methods travel time based and vehicle emissions impact (VEI) based which aim to reduce the travel time for emergency vehicle (resilience), and reduce vehicle emissions for general vehicle (sustainability). In the experiment, several realistic traffic scenarios are simulated by SUMO to test the proposed navigation method. The experimental results have demonstrated the efficient convergence of the vehicle navigation agents and their effectiveness to make optimal decisions under the volatile traffic conditions. Travel time based reward schema perform better in reducing travel time however VEI based show better result in reducing vehicle emissions. Furthermore, the results also show that the proposed method has huge potential to provide a better navigation solution comparing with the benchmark routing optimisation algorithms.
Assessment of the accuracy of estimation of gestational age in cattle from placentome size using inverse regression
Creators: name: KE Lawrence
name: FD Adeyinka
name: RA Laven
name: G Jones
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: AIMS: To assess, in dairy cows between 60–160 days of gestation, whether the agreement between actual gestational age and that predicted by placentome size could be improved by using individual placentome measurements rather than a single average, and to identify how increasing the number of placentomes measured improved the prediction. METHODS: Data were obtained from 58 cows examined using transrectal ultrasonography every 10 days between 60–130 days, and every 15 days between 130–160 days of gestation. For each cow, four to six placentomes in each of the pregnant and non-pregnant horns were examined from the region of the uterus near to the cervix. A mixed-effects model, which included cow as a random effect, and a simple linear regression which ignored within-cow correlation, were fitted to the data. Inverse regression was used to compare the 95% prediction bands obtained for estimating gestational age using the means of three, five or eight placentome measurements. RESULTS: The fit of the mixed effects model was better than a simple linear regression (p<0.001) but the fitted lines from the two models were very similar. Using the simple regression model, for a mean placentome length of 15 mm estimated gestational age was 100 days, with 95% CI of 68–131 days for measurement of three placentomes, and 80–120 days for eight placentomes. CONCLUSIONS: The agreement between placentome size and gestational age was improved by increasing the number of placentomes measured. Direct comparison of these CI with those for other published fetal measures was not possible as similar prediction bands have not previously been calculated for fetal measures; however one study reported a residual SD which had been calculated using size measurements as the predictor variable and age as the response variable. Using these data 95% CI were calculated to be ±9 days for crown-rump length and ±25 days for uterine diameter. These are likely to be an underestimate of the true CI and do not take account of the increase in variance of the difference between predicted and actual gestational age as gestational age increases. CLINICAL RELEVANCE: Placentome measurement may be useful for estimating fetal age in late gestation. Further research is required to better establish the agreement between gestational age and the fetal measurements which are currently used to estimate fetal age.
Pulsed corona discharge oxidation of aqueous carbamazepine micropollutant
Creators: name: Ajo, Petri
name: Krzymyk, Ewelina
name: Preis, Sergei
name: Iakov Kornev
name: Kronberg, Leif
name: Louhi-Kultanen, Marjatta
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: The anti-epileptic drug carbamazepine (CBZ) receives growing attention due to slow biodegradation and inherent accumulation in the aquatic environment. The application of a gas-phase pulsed corona discharge (PCD) was investigated to remove CBZ from synthetic solutions and spiked wastewater effluent from a municipal wastewater treatment facility. The treated water was showered between high voltage (HV) wires and grounded plate electrodes, to which ultra-short HV pulses were applied. CBZ was readily oxidized and 1-(2-benzaldehyde)-4-hydroquinazoline-2-one (BQM) and 1-(2-benzaldehyde)-4-hydro-quinazoline-2,4-dione (BQD) were identified as the most abundant primary transformation products, which, contrary to CBZ ozonation data available in the literature, were further easily oxidized with PCD: BQM and BQD attributed to only a minor portion of the target compound oxidized. In concentrations commonly found in wastewater treatment plant effluents (around 5 µg L−1), up to 97% reduction in CBZ concentration was achieved at mere 0.3 kW h m−3 energy consumption, and over 99.9% was removed at 1 kW h m−3. The PCD application proved to be efficient in the removal of both the parent substance and its known transformation products, even with the competing reactions in the complex composition of wastewater.
An explicit expression for the static structure factor for a multi-Yukawa fluid: the one-component case
Creators: name: Ó. Vázquez-Rodríguez
name: H. Ruiz-Estrada
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Hematology
subject: Computational Biology

description: By using the mean spherical approximation, we obtain an analytical expression for the static structure factor (SSF) for a monodisperse system of particles interacting through a potential given by a hard-sphere contribution and M Yukawa terms. This expression depends on scaling matrix Γ, which is determined by solving a set of nonlinear equations. Our theoretical results show that using three Yukawa terms in the closure relation greatly improves the accuracy when compared with hypernetted-chain closure and Monte Carlo simulation data, which display a secondary low-k peak in the SSF, due to the formation of an intermediate range order structure governed by a short-range attraction and a long-range repulsion. We discuss the appearance of such a peak in terms of the microstructure order given by the radial distribution function. Following the original proposal made by Waisman (Mol Phys. 1973; 25:45–48), we give an explicit expression that improves the structural properties of a hard-sphere system.
title: Firmware-Update von CPAP-Heimbeatmungsgeräten zur Beatmung von COVID19-Patienten während des weltweiten Mangels an klinischen Beatmungsgeräten
Creators: name: Giesler, Thomas
Publisher: name: Technische Hochschule Nürnberg Georg Simon Ohm
Year: 2020
Subjects: subject: 6 Technik, Medizin, angewandte Wissenschaften

description: Das Upgrade von hunderttausenden vorhandenen CPAP-Heimtherapiegeräten mit BIPAP/Biphase-Beatmungsfunktionalität kann dazu beitragen, der momentan drohenden weltweiten Beatmungsgeräteknappheit entgegenzuwirken und zu verhindern, dass vielleicht bald tausende COVID19-Patienten nicht die erforderliche, teils lebensrettende Atemunterstützung erhalten können. Diese Lösung könnte in kürzester Zeit zur Verfügung gestellt werden, da sie rein softwarebasiert ist.
title: Design und Synthese von dichroitischen Nah-Infrarot-Farbstoffen
Creators: name: Lorenz, Theresa Gudrun
Publisher: name: UNSPECIFIED
Year: 2020

description: Ziele dieser Arbeit waren das Design und die Untersuchung der Synthese, sowie der Eigenschaften, neuer Akzeptor-Bausteine für die Anwendung in dichroitischen Nah-Infrarot-Farbstoffen. Auf Grund der hohen Elektronenaffinität und einfachen Modifizierbarkeit wurde die Substanzklasse der Benzothiadiazole als Basis für das Design gewählt. Um die Absorption in den Nah-Infrarot-Bereich zu verschieben fand anschließend auf Basis quantenchemischer Rechnungen die Kombination zweier Konzepte Anwendung: Zum einen die Steigerung des Imin-Stickstoff-Anteils im annelierten Ringsystem und zum anderen die zusätzliche Einführung von kleinen elektronenziehenden Substituenten. Da in Hinblick auf die Synthese wenig bekannt war, wurden zur Untersuchung neuer Routen zunächst Modelverbindungen herangezogen, deren Übertragung auf die Farbstoffmoleküle durch den starken, deaktivierenden Effekt der elektronenarmen Systeme jedoch behindert wurde. Aus diesem Grund wurden alternative Syntheserouten untersucht, die zu einer Verkürzung und Vereinfachung der Synthesesequenz, bei gleichzeitiger Verwendung milder Reaktionsbedingungen, sowie einer deutlich besseren Reproduzierbarkeit und Skalierbarkeit, führten. Die synthetisierten Verbindungen zeigten anschließend außerdem die gewünschten optischen Eigenschaften.
Inferring Symbolic Automata
Creators: name: Fisman, Dana
name: Frenkel, Hadar
name: Zilles, Sandra
Publisher: name: CISPA
Year: 2024

description: We study the learnability of symbolic finite state automata (SFA), a model shown useful in many applications in software verification. The state-of-the-art literature on this topic follows the query learning paradigm, and so far all obtained results are positive. We provide a necessary condition for efficient learnability of SFAs in this paradigm, from which we obtain the first negative result. The main focus of our work lies in the learnability of SFAs under the paradigm of identification in the limit using polynomial time and data, and its strengthening efficient identifiability, which are concerned with the existence of a systematic set of characteristic samples from which a learner can correctly infer the target language. We provide a necessary condition for identification of SFAs in the limit using polynomial time and data, and a sufficient condition for efficient learnability of SFAs. From these conditions we derive a positive and a negative result. The performance of a learning algorithm is typically bounded as a function of the size of the representation of the target language. Since SFAs, in general, do not have a canonical form, and there are trade-offs between the complexity of the predicates on the transitions and the number of transitions, we start by defining size measures for SFAs. We revisit the complexity of procedures on SFAs and analyze them according to these measures, paying attention to the special forms of SFAs: normalized SFAs and neat SFAs, as well as to SFAs over a monotonic effective Boolean algebra. This is an extended version of the paper with the same title published in CSL’22.
title: Firmware update of CPAP home mechanical ventilators for respiration of COVID19 patients during the worldwide shortage of clinical ventilators
Creators: name: Giesler, Thomas
Publisher: name: Technische Hochschule Nürnberg Georg Simon Ohm
Year: 2020
Subjects: subject: 6 Technik, Medizin, angewandte Wissenschaften

description: Upgrading hundreds of thousands of already available CPAP home therapy machines to function as BIPAP/Bilevel machines may help to mitigate the current global threat of a shortage of ventilators. The concept may help to prevent the scenario that soon potentially thousands of COVID-19 patients will not be able to receive the necessary and sometimes life-saving respiratory support. This solution could be made available in very short time, because it is purely software based.
Consentimiento informado padres.pdf
Creators: name: Castro-Garcia, David
Publisher: name: figshare
Year: 2016
Subjects: subject: Education
subject: 170103 Educational Psychology
subject: FOS: Psychology
subject: 100503 Computer Communications Networks
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: El propósito de este consentimiento informado es entregar a los participantes del programa de investigación ”Diseño, implementación y evaluación de estrategias de enseñanza – aprendizaje para el desarrollo y fortalecimiento de competencias tecnológicas en grado Décimo y Undécimo, mediante la creación y el uso educativo de herramientas TIC” y a sus responsables directos, una explicación de la naturaleza del programa de investigación, así como el rol que van asumir durante la etapa de implementación.
title: Characterization of miR-574-5p decoy to CUGBP1 in human lung cancer cells using a mass spectrometry proteomics approach
Creators: name: Emmerich, Anne Caterina
Publisher: name: UNSPECIFIED
Year: 2020

description: The bioactive lipid mediator prostaglandin (PG) E2 is generated by the enzyme microsomal prostaglandin E2 synthase-1 (mPGES-1). Especially in lung tumors, mPGES-1 was shown to be significantly overexpressed which contributes to a pro-tumorigenic microenvironment. Current medication interfering with the negative effects of PGE2 comprise only non-steroidal anti-inflammatory drugs (NSAIDs). While these have effective analgesic properties and are commonly used as pain killers, treatment of tumor growth is still inconclusive. Probably, only subgroups of cancer patients exhibit an abnormal prostanoid profile. Therefore, a reliable biomarker is necessary to identify patients who could benefit from said treatment. In a recent study, it was discovered that a specific microRNA (miR) can induce mPGES-1 gene expression. The miR-574-5p prevents binding of the inhibitory CUG-RNA binding protein 1 (CUGBP1) to the 3´ untranslated region (UTR) of mPGES-1. This non-canonical decoy function of miR-574-5p leads to an increased mPGES-1 protein level. Following, an induction of PGE2 formation triggers the progression of lung tumor growth in vivo. Interestingly, the entire influence on tumor progression could be blocked with the addition of a specific mPGES-1 inhibitor, confirming the huge influence of miR-574-5p on (patho-) physiological mPGES-1 functions. In this study, a proteomics approach was conducted in order to further characterize this decoy mechanism in human lung cancer cells. The aim was to gather global insights into the proteome changes related to miR-574-5p and CUGBP1, especially in a compartment specific manner. Further, it was aimed to identify new CUGBP1 targets and find out if they are also affected by the decoy function of miR-574-5p. Two new CUGBP1 targets were validated herein: NADH-Ubiquinone Oxidoreductase Core Subunit S2 (NDUFS2) and Mothers against decapentaplegic homolog 2 (SMAD2). However, both NDUFS2 and SMAD2 are independent from miR-574-5p levels. In a bioinformatical 3’UTR analysis of potential CUGBP1 targets, it was shown that the specific splicing pattern of mPGES-1 is unique, comprising two long CUGBP1 binding motifs with a 3’UTR intron in between. Only 11 other transcripts harbor a similar but not identical pattern in their sequence. Hence, it is assumable that this novel decoy mechanism is specifically regulating mPGES-1 in A549 lung cancer cells. This might be caused by the unique splice pattern of mPGES-1. However, further experiments are needed to confirm this hypothesis. Nevertheless, specificity of the decoy mechanism would open up new opportunities for lung cancer patients. By using miR-574-5p as a biomarker, one could stratify those patients with high mPGES-1 levels who have a higher chance to benefit from the anti-tumorigenic potential of NSAID therapy.
Hardware-Software Codesign for Mitigating Spectre
Creators: name: Mosier, Nicholas
name: Eselius, Kate
name: Nemati, Hamed
name: Mitchell, John
name: Trippel, Caroline
Publisher: name: CISPA
Year: 2024

description: Spectre attacks exploit control- and data-flow (mis)prediction on modern processors to transiently leak program secrets. Comprehensively mitigating Spectre leakage is hard, and doing so while preserving the program’s performance is even harder: no existing Spectre mitigations are widely deployed due to their high overhead or high complexity. We claim that a comprehensive, efficient, and low-complexity mitigation for Spectre attacks requires engaging in software-compiler-hardware co-design. In our talk, we will pitch such a co-designed Spectre mitigation that will be widely deployable at a low cost in security-critical applications. As a first step towards this goal, we have developed Serberus, a comprehensive and proven-correct Spectre mitigation for constant-time code that targets existing hardware. We are currently exploring lightweight hardware support to improve Serberus’ performance in other application domains.
Exploring the role of local heirloom germplasm in expanding western Washington dry bean production
Creators: name: Brouwer, Brook
name: Winkler, Louisa
name: Atterberry, Kelly
name: Jones, Stephen
name: Miles, Carol
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Plant Biology

description: Increasing production of dry beans (Phaseolus vulgaris L.) could contribute to the sustainability of regional agricultural systems. This study in western Washington identified 24 distinct dry bean varieties grown in the region for 20–130 years; varieties originated from diverse geographic areas and were maintained because growers valued the culinary, visual, and agronomic traits as well as history and marketability. Primary barriers to increased production were access to scale-appropriate equipment and drying beans in the field prior to harvest. Locally conserved germplasm may have value in participatory plant breeding projects that recognize the contributions of regional farmers.