cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Identification of genetic variants in CFAP221 as a cause of primary ciliary dyskinesia
Creators: name: Knowles, M.R.
name: Sears, P.R.
name: Zariwala, M.A.
name: Charng, W.-L.
name: Bustamante-Marin, X.M.
name: Shapiro, A.
name: Conrad, D.F.
name: Leigh, M.W.
name: Ostrowski, L.E.
Publisher: name: Springer Nature
Year: 2020

description: Primary ciliary dyskinesia (PCD) is a rare disorder that affects the biogenesis or function of motile cilia resulting in chronic airway disease. PCD is genetically and phenotypically heterogeneous, with causative mutations identified in over 40 genes; however, the genetic basis of many cases is unknown. Using whole-exome sequencing, we identified three affected siblings with clinical symptoms of PCD but normal ciliary structure, carrying compound heterozygous loss-of-function variants in CFAP221. Computational analysis suggests that these variants are the most damaging alleles shared by all three siblings. Nasal epithelial cells from one of the subjects demonstrated slightly reduced beat frequency (16.5 Hz vs 17.7 Hz, p = 0.16); however, waveform analysis revealed that the CFAP221 defective cilia beat in an aberrant circular pattern. These results show that genetic variants in CFAP221 cause PCD and that CFAP221 should be considered a candidate gene in cases where PCD is suspected but cilia structure and beat frequency appear normal.
title: Imaging Findings of Autoinmune Pancreatitis on CT and MRI: Local Experience in Universidad de Chile Clinical Hospital
Creators: name: Araya Rojas, Rodrigo
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Inflammation
subject: Comparative studies
subject: MR
subject: CT
subject: Pancreas
subject: Abdomen

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Chronic pancreatitis has been defined as a chronic inflammatory condition characterized by fibrosis and destruction of the exocrine and eventually endocrine tissue of the pancreas, leading to pain and permanent loss of function [1, 2]. The main...
Flare Hybrids
Creators: name: Tomczak, M.
name: Dubieniecki, P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Svestka (Solar Phys. 1989, 121, 399) on the basis of the Solar Maximum Mission observations introduced a new class of flares, the so-called flare hybrids. When they start, they look as typical compact flares (phase 1), but later on they look like flares with arcades of magnetic loops (phase 2). We summarize the features of flare hybrids in soft and hard X-rays as well as in extreme-ultraviolet; these allow us to distinguish them from other flares. Additional energy release or long plasma cooling timescales have been suggested as possible cause of phase 2. Estimations of frequency of flare hybrids have been given. Magnetic configurations supporting their origin have been presented. In our opinion, flare hybrids are quite frequent and a difference between lengths of two interacting systems of magnetic loops is a crucial parameter for recognizing their features.
description: 15 pages, 4 figures, to appear in Solar Physics
A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance
Creators: name: Alkuraya, F.S.
name: Knowles, M.R.
name: Montoro, D.T.
name: Vinarsky, V.
name: Carson, J.
name: Hariri, L.P.
name: Taylor, M.S.
name: Shamseldin, H.E.
name: Leung, H.M.
name: Sears, P.R.
name: Sabatini, D.M.
name: Chivukula, R.R.
name: Daniels, M.L.A.
name: Omran, H.
name: Almogarri, I.
name: Tearney, G.J.
name: Dougherty, G.W.
name: Black, K.E.
name: Zariwala, M.A.
name: Yang, J.
name: Frenkel, E.M.
Publisher: name: Nature Research
Year: 2020

description: Mucociliary clearance, the physiological process by which mammalian conducting airways expel pathogens and unwanted surface materials from the respiratory tract, depends on the coordinated function of multiple specialized cell types, including basal stem cells, mucus-secreting goblet cells, motile ciliated cells, cystic fibrosis transmembrane conductance regulator (CFTR)-rich ionocytes, and immune cells1,2. Bronchiectasis, a syndrome of pathological airway dilation associated with impaired mucociliary clearance, may occur sporadically or as a consequence of Mendelian inheritance, for example in cystic fibrosis, primary ciliary dyskinesia (PCD), and select immunodeficiencies3. Previous studies have identified mutations that affect ciliary structure and nucleation in PCD4, but the regulation of mucociliary transport remains incompletely understood, and therapeutic targets for its modulation are lacking. Here we identify a bronchiectasis syndrome caused by mutations that inactivate NIMA-related kinase 10 (NEK10), a protein kinase with previously unknown in vivo functions in mammals. Genetically modified primary human airway cultures establish NEK10 as a ciliated-cell-specific kinase whose activity regulates the motile ciliary proteome to promote ciliary length and mucociliary transport but which is dispensable for normal ciliary number, radial structure, and beat frequency. Together, these data identify a novel and likely targetable signaling axis that controls motile ciliary function in humans and has potential implications for other respiratory disorders that are characterized by impaired mucociliary clearance.
The expanding phenotype of OFD1-related disorders: Hemizygous loss-of-function variants in three patients with primary ciliary dyskinesia
Creators: name: Knowles, M.R.
name: Kinghorn, B.
name: Rosenfeld, M.
name: Zariwala, M.A.
name: DeBrosse, S.
name: Wolf, W.E.
name: Strausbaugh, S.
name: Aitken, M.L.
name: Hannah, W.B.
Publisher: name: Wiley-Blackwell
Year: 2019

description: Background: OFD1 has long been recognized as the gene implicated in the classic dysmorphology syndrome, oral-facial-digital syndrome type I (OFDSI). Over time, pathogenic variants in OFD1 were found to be associated with X-linked intellectual disability, Joubert syndrome type 10 (JBTS10), Simpson-Golabi-Behmel syndrome type 2 (SGBS2), and retinitis pigmentosa. Recently, OFD1 pathogenic variants have been implicated in primary ciliary dyskinesia (PCD), a disorder of the motile cilia with a phenotype that includes recurrent oto-sino-pulmonary infections, situs abnormalities, and decreased fertility. Methods: We describe three male patients with PCD who were found to have hemizygous pathogenic variants in OFD1, further supporting that PCD is part of a clinical spectrum of OFD1-related disorders. In addition, we provide a review of the available clinical literature describing patients with OFD1 variants and highlight the phenotypic variability of OFD1-related disease. Results: Some individuals with hemizygous OFD1 variants have PCD, either apparently isolated or in combination with other features of OFD1-related disorders. Conclusion: As clinicians consider the presence or absence of conditions allelic at OFD1, PCD should be considered part of the spectrum of OFD1-related disorders. Understanding the OFD1-related disease spectrum may allow for more focused genetic testing and more timely management of treatable sequelae.
(101576) Mary Ann Spivey
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Combined application of compost and FYM with inorganic fertilizers for production of onion in debub ari district, Southwestern Ethiopia
Creators: name: Atinafu Tunebo
name: Shemelis Tesema
name: Merdikios Malla
name: Muhaba Sultan
name: Yenesew Anmaw
name: Belayneh Lemage
name: Atinafu Tunebo
name: Shemelis Tesema
name: Merdikios Malla
name: Muhaba Sultan
name: Yenesew Anmaw
name: Belayneh Lemage
Publisher: name: Unknown
Year: 2022
Subjects: subject: Crop Production/Industries
subject: Farmyard manure
subject: Compost
subject: Inorganic fertilizer
subject: Onion

description: Soil fertility depletion is a serious problem in Ethiopian highland due to leaching of topsoil by runoff, which reduces production and productivity. This experiment conducted in Debub Ari district for two years with the aim of investigating single and combined effect of compost and FYM with inorganic fertilizer on soil fertility improvement and onion crop production. The treatment includes T1) Control, T2) Recommended NP (69/30), T3) NPSZnB (120N, 92P2O5, 20.06S, 5.89Zn, 0.66B) kg ha-1 (264 kg NPSZnB + 161 kg urea), T4) 10 t ha-1 FYM, T5) 10 t ha-1 compost, T6) 5 tha-1 FYM + 50% of treatment-3 and T7) 5 t ha-1 compost + 50% of treatment-3. Treatments are arranged in randomized complete block design with three replications. Soil before the experiment showed moderately acidic, moderate in organic matter and boron, low in sulfur high in available P and total nitrogen. The results showed significant differences among the treatments on onion plant height, bulb diameter, marketable and biological yield. The highest total yield 19.99 t ha-1, 19.59 t ha-1 and 19.25 t ha-1 was recorded from NPSZnB (120N, 92P2O5, 20.06S, 5.89Zn, 0.66B) kg ha-1, 5 t ha-1 compost + 50% of T-3 and 5 t ha-1 FYM + 50% of T-3 respectively and that increase yield by 39%, 35% and 33% over the control. Soils after the experiment become medium in sulfur remain static in available boron and total nitrogen. Economic feasibility that the maximum net benefit of 246059 and 242442 ETB ha-1 with acceptable %MRR of 290 and 1300 was obtained with the application of NPSZnB (120N, 92P2O5, 20.06S, 5.89Zn, 0.66B) kg ha-1 and 5 t ha-1 FYM + 50% of T-3, respectively. Therefore, the application of those two treatments is recommended for higher yield production in the study area.
Recurring large deletion in DRC1 (CCDC164) identified as causing primary ciliary dyskinesia in two Asian patients
Creators: name: Sasaki, Y.
name: Kudoh, S.
name: Zariwala, M.A.
name: Nykamp, K.
name: Keicho, N.
name: Leigh, M.W.
name: Truty, R.
name: Hijikata, M.
name: Knowles, M.R.
name: Inaba, A.
name: Morimoto, K.
name: Guo, T.-C.
name: Ohta, K.
name: Yamada, H.
Publisher: name: Wiley-Blackwell
Year: 2019

description: Background: Primary ciliary dyskinesia (PCD) is a relatively rare autosomal recessive or X-linked disorder affecting ciliary function. In the set of causative genes, however, predominant pathogenic variants remain unknown in Asia. Method: A diagnosis of PCD was made following a modern comprehensive testing including genetic analysis; targeted resequencing for screening variants, and Sanger sequencing for determination of the breakpoints, with an additional review of databases to calculate the deletion frequency. A multiplexed PCR-based detection method has also been developed. Results: We ascertained a 50-year-old Japanese male who had been diagnosed with diffuse panbronchiolitis (DPB), but refractory to macrolide therapy. We reevaluated the case and identified a large homozygous deletion spanning exons 1 to 4 of the DRC1 and determined the breakpoints (NM_145038.4: c.1-3952_540 + 1331del27748-bp). In the PCD cohort at the University of North Carolina, we found a female PCD patient of Korean descent harboring the same homozygous deletion. From the Invitae testing cohort, we extracted four carriers of the same deletion among 965 Asian individuals, whereas no deletion was found in the 23,951 non-Asians. Conclusion: We speculate that the DRC1 deletion is a recurrent or perhaps founder mutation in Asians. The simple PCR method could be a useful screening tool.
title: Complete Duplication Of The Pituitary Gland: Report Of Three Cases And Review Of Imaging Findings and Associated Anomalies
Creators: name: Lushchenkova, Oksana
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Developmental disease
subject: Diagnostic procedure
subject: MR
subject: Paediatric
subject: Neuroradiology brain
subject: Head and neck

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Review the imaging findings of complete duplication of the pituitary gland (DPG). Review of associated anomalies. Review the clinical contexts in which can be...
Nasal Nitric Oxide in Primary Immunodeficiency and Primary Ciliary Dyskinesia: Helping to Distinguish Between Clinically Similar Diseases
Creators: name: Knowles, M.R.
name: Alizadehfar, R.
name: Zysman-Colman, Z.N.
name: Zariwala, M.A.
name: Vinh, D.C.
name: Shapiro, A.J.
name: NyKamp, K.R.
name: Kaspy, K.R.
Publisher: name: Springer New York LLC
Year: 2019

description: Purpose: Primary ciliary dyskinesia (PCD) is a rare disorder of the mucociliary clearance leading to recurrent upper and lower respiratory tract infections. PCD is difficult to clinically distinguish from other entities leading to recurrent oto-sino-pulmonary infections, including primary immunodeficiency (PID). Nasal nitric oxide (nNO) is a sensitive and specific diagnostic test for PCD, but it has not been thoroughly examined in PID. Past publications have suggested an overlap in nNO levels among subjects with PCD and PID. We sought to determine if nNO measurements among patients diagnosed with PID would fall significantly above the established PCD diagnostic cutoff value of 77 nL/min. Methods: Children > 5 years old and adults with definitive PID or PCD diagnoses were recruited from outpatient subspecialty clinics. Participants underwent nNO testing by standardized protocol using a chemiluminescence analyzer and completed a questionnaire concerning their chronic oto-sino-pulmonary symptoms, including key clinical criteria specific to diagnosed PCD (neonatal respiratory distress at term birth, year-round cough or nasal congestion starting before 6 months of age, any organ laterality defect). Results: Participants included 32 patients with PID, 27 patients with PCD, and 19 healthy controls. Median nNO was 228.9.1 nL/min in the PID group, 19.7 nL/min in the PCD group, and 269.4 in the healthy controls (p < 0.0001). Subjects with PCD were significantly more likely to report key clinical criteria specific to PCD, but approximately 25% of PID subjects also reported at least 1 of these key clinical criteria (mainly year-round cough or nasal congestion). Conclusions: While key clinical criteria associated with PCD often overlap with the symptoms reported in PID, nNO measurement by chemiluminescence technology allows for effective discrimination between PID and PCD.
title: The fat and the furious: misbehavior of the fat in the abdominal cavity
Creators: name: Devos, Hannes
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Diagnostic procedure
subject: MR
subject: CT
subject: Abdomen
subject: Inflammation

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To identify the different patterns of abdominal fat necrosis and inflammation. To understand the differencebetween these 'no touch lesions' and other pathologies. To be aware of the most commom differential...
title: Diagnostic accuracy of bone scintigraphy, positron emission tomography/computed tomography (PET/CT) and whole body magnetic resonance imaging (MRI) in the detection of bone metastasis among patients with prostate cancer using histopathologic report and / or clinical follow-up as the reference standard: A systematic review
Creators: name: Acayan, Emily
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Genital / Reproductive system male
subject: Oncology
subject: Hybrid Imaging
subject: Nuclear medicine conventional
subject: MR
subject: PET-CT
subject: Screening
subject: Molecular imaging
subject: Cancer
subject: Metastases

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: GENERAL OBJECTIVE To compare the accuracy of bone scintigraphy, PET/CT, and MRI in the diagnosis of bone metastasis. SPECIFIC OBJECTIVE To determine the sensitivity, specificy, positive likelihood ratio (PLR), negative likelihood ration...
Lack of GAS2L2 Causes PCD by Impairing Cilia Orientation and Mucociliary Clearance
Creators: name: Amselem, S.
name: Zariwala, M.A.
name: Mitchell, B.J.
name: Ostrowski, L.E.
name: Herring, L.E.
name: Yin, W.-N.
name: Jania, C.M.
name: Zeman, K.L.
name: Thomas, L.
name: Brotslaw, E.J.
name: Grubb, B.R.
name: Werner, M.E.
name: Bustamante-Marin, X.M.
name: Sears, P.R.
name: Refabért, L.
name: Legendre, M.
name: Rogers, T.D.
name: Knowles, M.R.
name: Escudier, E.
Publisher: name: Cell Press
Year: 2019

description: Primary ciliary dyskinesia (PCD) is a genetic disorder in which impaired ciliary function leads to chronic airway disease. Exome sequencing of a PCD subject identified an apparent homozygous frameshift variant, c.887_890delTAAG (p.Val296Glyfs ∗ 13), in exon 5; this frameshift introduces a stop codon in amino acid 308 of the growth arrest-specific protein 2-like 2 (GAS2L2). Further genetic screening of unrelated PCD subjects identified a second proband with a compound heterozygous variant carrying the identical frameshift variant and a large deletion (c.867_ ∗ 343+1207del; p.?) starting in exon 5. Both individuals had clinical features of PCD but normal ciliary axoneme structure. In this research, using human nasal cells, mouse models, and X.laevis embryos, we show that GAS2L2 is abundant at the apical surface of ciliated cells, where it localizes with basal bodies, basal feet, rootlets, and actin filaments. Cultured GAS2L2-deficient nasal epithelial cells from one of the affected individuals showed defects in ciliary orientation and had an asynchronous and hyperkinetic (GAS2L2-deficient = 19.8 Hz versus control = 15.8 Hz) ciliary-beat pattern. These results were recapitulated in Gas2l2 −/− mouse tracheal epithelial cell (mTEC) cultures and in X. laevis embryos treated with Gas2l2 morpholinos. In mice, the absence of Gas2l2 caused neonatal death, and the conditional deletion of Gas2l2 impaired mucociliary clearance (MCC) and led to mucus accumulation. These results show that a pathogenic variant in GAS2L2 causes a genetic defect in ciliary orientation and impairs MCC and results in PCD.
Diagnosis of primary ciliary dyskinesia: An official American thoracic society clinical practice guideline
Creators: name: Chilvers, M.A.
name: Yilmaz, O.
name: Pittman, J.E.
name: Nogee, L.M.
name: Leigh, M.W.
name: Olivier, K.N.
name: Davis, S.D.
name: Knowles, M.R.
name: Sagel, S.D.
name: Shapiro, A.J.
name: Daniel, S.J.
name: Ware, S.M.
name: Manion, M.
name: Morgan, L.
name: Rosenfeld, M.
name: Guadagno, E.
name: Jones, M.H.
name: Ehrne, L.
name: Cooper, M.L.
name: Zariwala, M.A.
name: Ferkol, T.W.
name: Josephson, M.
name: Janahi, I.A.
name: Milla, C.
name: Eastvold, T.
name: Anton, B.
name: Dell, S.D.
name: Leigh Anne Daniels, M.
name: Lavergne, V.
name: Polineni, D.
Publisher: name: American Thoracic Society
Year: 2018

description: Background: This document presents the American Thoracic Society clinical practice guidelines for the diagnosis of primary ciliary dyskinesia (PCD). Target Audience: Clinicians investigating adult and pediatric patients for possible PCD. Methods: Systematic reviews and, when appropriate, meta-Analyses were conducted to summarize all available evidence pertinent to our clinical questions. Evidence was assessed using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach for diagnosis and discussed by amultidisciplinary panelwith expertise in PCD. Predetermined conflict-of-interest management strategies were applied, and recommendations were formulated, written, and graded exclusively by the nonconflicted panelists. Three conflicted individuals were also prohibited from writing, editing, or providing feedback on the relevant sections of the manuscript. Results: After considering diagnostic test accuracy, confidence in the estimates for each diagnostic test, relative importance of test results studied, desirable and undesirable direct consequences of each diagnostic test, downstream consequences of each diagnostic test result, patient values and preferences, costs, feasibility, acceptability, and implications for health equity, the panel made recommendations for or against the use of specific diagnostic tests as compared with using the current reference standard (transmission electron microscopy and/or genetic testing) for the diagnosis of PCD. Conclusions: The panel formulated and provided a rationale for the direction as well as for the strength of each recommendation to establish the diagnosis of PCD.
title: The many faces of Ankylosing Spondylitis on MRI- a practical guide for young radiologists
Creators: name: Coroiu, Roxana
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Musculoskeletal spine
subject: Pelvis
subject: Musculoskeletal joint
subject: MR
subject: Diagnostic procedure
subject: Computer Applications-Detection, diagnosis
subject: Inflammation
subject: Arthritides
subject: Acute

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To describe the radiological signs of axial spondylarthritis (AxSpA) and non-radiographic axial spondylarthritis (nrAxSpA) and to correlate clinical and pathological features, in order to recognize the early stages of the diseases. To provide a...
Topic modeling for analyzing open-ended survey responses
Creators: name: Pietsch, Andra-Selina
name: Lessmann, Stefan
Publisher: name: Humboldt-Universität zu Berlin
Year: 2019
Subjects: subject: market research
subject: open-ended responses
subject: text analytics
subject: short text topic models
subject: 650 Management und unterstützende Tätigkeiten

description: Open-ended responses are widely used in market research studies. Processing of such responses requires labour-intensive human coding. This paper focuses on unsupervised topic models and tests their ability to automate the analysis of open-ended responses. Since state-of-the-art topic models struggle with the shortness of open-ended responses, the paper considers three novel short text topic models: Latent Feature Latent Dirichlet Allocation, Biterm Topic Model and Word Network Topic Model. The models are fitted and evaluated on a set of real-world open-ended responses provided by a market research company. Multiple components such as topic coherence and document classification are quantitatively and qualitatively evaluated to appraise whether topic models can replace human coding. The results suggest that topic models are a viable alternative for open-ended response coding. However, their usefulness is limited when a correct one-to-one mapping of responses and topics or the exact topic distribution is needed.
A versatile class of prototype dynamical systems for complex bifurcation cascades of limit cycles
Creators: name: Sándor, Bulcsú
name: Gros, Claudius
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computational Physics (physics.comp-ph)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: We introduce a versatile class of prototype dynamical systems for the study of complex bifurcation cascades of limit cycles, including bifurcations breaking spontaneously a symmetry of the system, period doubling bifurcations and transitions to chaos induced by sequences of limit cycle bifurcations. The prototype system consist of a $2d$-dimensional dynamical system with friction forces $f(V(\mathbf{x}))$ functionally dependent exclusively on the mechanical potential $V(\mathbf{x})$, which is typically characterized, here, by a finite number of local minima. We present examples for $d=1,2$ and simple polynomial friction forces $f(V)$, where the zeros of $f(V)$ regulate the relative importance of energy uptake and dissipation respectively, serving as bifurcation parameters. Starting from simple Hopf- and homoclinic bifurcations, complex sequences of limit cycle bifurcation are observed when energy uptake gains progressively in importance.
PreventionLab Verkehrssicherheit : Weiterentwicklung der Präventionsarbeit für Jugendliche und junge Erwachsene im urbanen Raum in Hinblick auf die Digitalisierung unserer Gesellschaft
Creators: name: Koller, Patrizia
name: Cordin, Christian
name: Hackenfort, Markus
name: Schnetzler, Nadja
Publisher: name: RoadCross Schweiz
Year: 2020
Subjects: Prävention
Verkehrssicherheit
Jugend
Schweiz
Digitalisierung
Veranstaltung
Urbaner Raum
305: Personengruppen (Alter, Herkunft, Geschlecht, Einkommen)
363: Umwelt- und Sicherheitsprobleme

description: Forschungsarbeit Teil 1 von 2
description: In der vorliegenden Publikation setzt sich RoadCross Schweiz in Zusammenarbeit mit dem Schweizerischen Versicherungsverband und der grosszügigen Unterstützung der AXA Stiftung für Prävention intensiv mit der Weiterentwicklung der Präventionsveranstaltung im Hinblick auf die Digitalisierung unserer Gesellschaft auseinander. Im Forschungsprojekt «PreventionLab Verkehrssicherheit» hat die Fachgruppe Verkehrs-, Sicherheits- und Umweltpsychologie am Departement Angewandte Psychologie der ZHAW Zürcher Hochschule für Angewandte Wissenschaften in einem ersten Schritt eine GAP-Analyse erstellt. Diese ermittelt literaturbasiert aktuelle urbane Mobilitätsformen und entsprechende Mobilitätsnutzungsbedürfnisse. Anschliessend findet eine konzeptbasierte Inhaltsevaluation der aktuellen Präventionsveranstaltung von RoadCross Schweiz im Hinblick auf den Themenschwerpunkt «Urbane Mobilität» statt. Die Lücke zwischen den Literaturbefunden und der Inhaltsevaluation wird in der GAP-Analyse festgehalten. In einem zweiten Schritt werden in ThinkTanks verschiedene Lösungsansätze zur Schliessung der Gaps erarbeitet. In kreativen Prozessen mit Präventionsexperten sowie der Zielgruppe der Jugendlichen und junge Erwachsenen werden gemeinsam neue Ansätze für nachhaltige Prävention entwickelt. Auszüge aus den Protokollen der ThinkTanks in Zürich und Lausanne sind ab Seite 57 zu finden. Um diesen Teil des Projekts abzuschliessen werden zudem in Form einer kurzen Zusammenfassung im vorliegenden Summary die Resultate aus dem Schlussbericht des Projekts «PreventionLab Verkehrssicherheit» ab Seite 69 publiziert.
title: Many faces of the centrilobular nodules: What should radiologists consider?
Creators: name: Lee, Nam Joo
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Inflammation
subject: Infection
subject: Foreign bodies
subject: Diagnostic procedure
subject: CT
subject: Thorax
subject: Lung

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: 1. To review wide spectrum of entities presenting as centrilobular nodules based on cases 2. To identify characteristic CT patterns of centrilobular nodules depending on underlying diseases. 3. To discuss the differential points in the diagnosis....
Study of the process $e^+e^-\to p\bar{p}$ in the c.m. energy range from threshold to 2 GeV with the CMD-3 detector
Creators: name: Akhmetshin, R. R.
name: Amirkhanov, A. N.
name: Anisenkov, A. V.
name: Aulchenko, V. M.
name: Banzarov, V. Sh.
name: Bashtovoy, N. S.
name: Berkaev, D. E.
name: Bondar, A. E.
name: Bragin, A. V.
name: Eidelman, S. I.
name: Epifanov, D. A.
name: Epshteyn, L. B.
name: Erofeev, A. L.
name: Fedotovich, G. V.
name: Gayazov, S. E.
name: Grebenuk, A. A.
name: Gribanov, S. S.
name: Grigoriev, D. N.
name: Gromov, E. M.
name: Ignatov, F. V.
name: Ivanov, V. L.
name: Karpov, S. V.
name: Kasaev, A. S.
name: Kazanin, V. F.
name: Khazin, B. I.
name: Kirpotin, A. N.
name: Koop, I. A.
name: Kovalenko, O. A.
name: Kozyrev, A. N.
name: Kozyrev, E. A.
name: Krokovny, P. P.
name: Kuzmenko, A. E.
name: Kuzmin, A. S.
name: Logashenko, I. B.
name: Lukin, P. A.
name: Mikhailov, K. Yu.
name: Okhapkin, V. S.
name: Otboev, A. V.
name: Pestov, Yu. N.
name: Pivovarov, S. G.
name: Popov, A. S.
name: Razuvaev, G. P.
name: Romanov, A. L.
name: Ruban, A. A.
name: Ryskulov, N. M.
name: Ryzhenenkov, A. E.
name: Shebalin, V. E.
name: Shemyakin, D. N.
name: Shwartz, B. A.
name: Shwartz, D. B.
name: Sibidanov, A. L.
name: Shatunov, P. Yu.
name: Shatunov, Yu. M.
name: Solodov, E. P.
name: Titov, V. M.
name: Talyshev, A. A.
name: Vorobiov, A. I.
name: Yudin, Yu. V.
name: Zharinov, Yu. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Using a data sample of 6.8 pb$^{-1}$ collected with the CMD-3 detector at the VEPP-2000 $e^+e^-$ collider we select about 2700 events of the $e^+e^- \to p\bar{p}$ process and measure its cross section at 12 energy ponts with about 6\% systematic uncertainty. From the angular distribution of produced nucleons we obtain the ratio $|G_{E}/G_{M}| = 1.49 \pm 0.23 \pm 0.30$.
title: Top 30 Signs in Chest X-Ray
Creators: name: Maneesh Ramki, CB
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Respiratory system
subject: Cardiovascular system
subject: Lung
subject: Digital radiography
subject: Diagnostic procedure
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To describe 30 classic signs in radiological imaging of chest. To provide illustrations of these signs. To discuss the pertinent features related to each sign with emphasis on the cause of the appearance of these signs, and the differential...
Contribution of forest products to rural household’s income and factor determining forest income in Masha district of Sheka zone, SWEPR, Ethiopia
Creators: name: Amanuel Afeto
name: Yemiru Tesfaye
name: Amanuel Afeto
name: Yemiru Tesfaye
Publisher: name: Unknown
Year: 2022
Subjects: subject: Crop Production/Industries
subject: Forest product
subject: Collection
subject: Income
subject: Dependence
subject: Masha

description: Rural people living around forests in Ethiopia depend on income from forest product collection as one of their livelihood activities. The forests of Sheka are threatened by unsustainable use and conversion to alternative land uses. This study was conducted to identify and quantify income from major forest products collected from the Sheka forest and examine factors that determine income from forest product collection. Quantitative and qualitative data were collected from primary and secondary sources. By stratified random sampling method, three kebeles were selected from the Masha district and 156 households were randomly selected from those kebeles and interviewed with a structured questionnaire. Descriptive and inferential statistics were determined by SPSS and STATA software. Multiple linear regression models were employed to determine the relationship between socio-economic factors and forest income. The result indicates 17 major forest product were collected and contributes an average of $1553.75 or 41.17% of their total annual income and was the highest contributor to total income. Forest income varies with agro-ecology and distance from the nearby markets in the study area. Households in the study area utilize more forest products for home consumption. Incomes from forest product collection are significantly related to the level of education of the household head, family size, and distance of home from the forest and market. Households in the study area depend to a higher degree on income from forest product collection and have an implication of sustainable management of forests in the long term.
Silicon nanowire based exclusive-OR gate using nonlinear optics for 40Gb/s DPSK signals
Creators: name: Li, F.
name: Vo, T. D.
name: Husko, C.
name: Pelusi, M.
name: Xu, D-X.
name: Densmore, A.
name: Ma, R.
name: Janz, S.
name: Eggleton, B. J.
name: Moss, David J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We demonstrate an all-optical XOR logic function for 40Gb/s differential phase-shift keyed (DPSK) data signals in the C-band, based on four-wave mixing (FWM) in a silicon nanowire. Error-free operation with a system penalty of ~ 3.0dB and ~ 4.3dB at 10-9 BER is achieved.
description: 6 pages, 5 figures, 28 references
title: Imaging features of medulloblastoma in children
Creators: name: Sarnecki, Jedrzej
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Cancer
subject: Diagnostic procedure
subject: MR-Spectroscopy
subject: MR
subject: CT
subject: Paediatric
subject: Oncology
subject: CNS

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To review basic information about medulloblastoma in children. To list the MRI and CT features of medulloblastomas. To discuss the differential diagnosis of posterior fossa tumors based on imaging findings. To present the current knowledge about the...
Role Of Teacher In Fighting Hoax In Indonesia
Creators: name: Galang, Toebagus
name: Widodo, Wahyu
name: Budoyo, Sapto
Publisher: name: Zenodo
Year: 2022
Subjects: APPI PT PGRI
PGRI
ICDESS2022
teacher
hoax

description: This material was presented in ACT +1 activities and International Conference on Digital Education and Social Science as a presenter
Primary ciliary dyskinesia: Keep it on your radar
Creators: name: Zariwala, M.A.
name: Ostrowski, L.E.
name: Rosenfeld, M.
Publisher: name: BMJ Publishing Group
Year: 2018

description: Primary ciliary dyskinesia (PCD) is a rare disorder of mucociliary clearance resulting in chronic oto-sinopulmonary disease. While the prevalence worldwide is estimated to be 1:10 000–1:15 000, it may be much higher in certain communities, especially where consanguinity is more prevalent. In the British South Asian community, for example, the prevalence has bren estimated at 1:2450, similar to that of cystic fibrosis among caucasians.
MIKE – Medien, Interaktion, Kinder, Eltern : Ergebnisbericht zur MIKE-Studie 2021
Creators: name: Suter, Lilian
name: Bernath, Jael
name: Willemse, Isabel
name: Külling, Céline
name: Waller, Gregor
name: Skirgaila, Patricia
name: Süss, Daniel
Publisher: name: ZHAW Zürcher Hochschule für Angewandte Wissenschaften
Year: 2023
Subjects: Mediennutzung
Kind
Primarschule
Schweiz
Eltern
302.23: Medien
305: Personengruppen (Alter, Herkunft, Geschlecht, Einkommen)

description: Das Kapitel "Zusammenfassung und Schlussfolgerungen" ist im Bericht zusätzlich in französischer und italienischer Sprache integriert.
description: MIKE steht für Medien, Interaktion, Kinder, Eltern. Die Studie wird seit 2015 im Zweijahresrhythmus durchgeführt und gibt ein repräsentatives Bild über das Medienverhalten von in der Schweiz lebenden Kindern im Primarschulalter. Im Jahr 2021 wurden insgesamt 1059 Kinder und 597 Elternteile befragt. 
Ein Auszug aus den Ergebnissen: Spielen, Sport und soziale Kontakte prägen die Freizeit von Primarschulkindern in der Schweiz. Erst dann folgt mit Gaming eine digitale Tätigkeit. Die neue MIKE-Studie zeigt zudem, dass das Mediennutzungsverhalten der Sechs- bis Dreizehnjährigen trotz erhöhter Nutzung während der Coronapandemie wieder auf einem ähnlichen Niveau wie zuvor ist.
Die erhobenen medialen und nonmedialen Freizeittätigkeiten von Kindern und Eltern werden jeweils nach folgenden Merkmalen analysiert: Alter, Geschlecht, Sprachregion, Herkunft, sozioökonomischer Status, Urbanitätsgrad und Familiengrösse.
Die MIKE-Studie liefert ein solides Fundament an repräsentativen Befunden für verschiedene Institutionen und Behörden sowie für Privatpersonen.
A selection effect boosting the contribution from rapidly spinning black holes to the Cosmic X-ray Background
Creators: name: Vasudevan, R. V.
name: Fabian, A. C.
name: Reynolds, C. S.
name: Aird, J.
name: Dauser, T.
name: Gallo, L. C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The Cosmic X-ray Background (CXB) is the total emission from past accretion activity onto supermassive black holes in active galactic nuclei (AGN) and peaks in the hard X-ray band (30 keV). In this paper, we identify a significant selection effect operating on the CXB and flux-limited AGN surveys, and outline how they must depend heavily on the spin distribution of black holes. We show that, due to the higher radiative efficiency of rapidly-spinning black holes, they will be over-represented in the X-ray background, and therefore could be a dominant contributor to the CXB. Using a simple bimodal spin distribution, we demonstrate that only 15 per cent maximally-spinning AGN can produce 50 per cent of the CXB. We also illustrate that invoking a small population of maximally-spinning black holes in CXB synthesis models can reproduce the CXB peak without requiring large numbers of Compton-thick AGN. The spin bias is even more pronounced for flux-limited surveys: 7 per cent of sources with maximally-spinning black holes can produce half of the source counts. The detectability for maximum spin black holes can be further boosted in hard (>10 keV) X-rays by up to ~60 per cent due to pronounced ionised reflection, reducing the percentage of maximally spinning black holes required to produce half of the CXB or survey number counts further. A host of observations are consistent with an over-representation of high-spin black holes. Future NuSTAR and ASTRO-H hard X-ray surveys will provide the best constraints on the role of spin within the AGN population.
description: 13 pages, 1 table, 7 figures. Accepted for publication in MNRAS (replaces previous submitted version)
Nachhaltiger durch längere Nutzung : Befragung zu Smartphonekauf und -nutzung in der Schweiz
Creators: name: Skirgaila, Patricia
name: Streule, Pascal
name: Külling, Céline
name: Blumer, Yann
name: Waller, Gregor
Publisher: name: ZHAW Zürcher Hochschule für Angewandte Wissenschaften
Year: 2023
Subjects: Smartphone
Lebensdauer
Nachhaltigkeit
Nachhaltiges Verhalten
Schweiz
004: Informatik
333: Bodenwirtschaft und Ressourcen

description: Dieser Bericht schliesst das medienpsychologische Teilprojekt des interdisziplinären Hauptprojekts «Lifesaving» ab. Mit dem Forschungsprojekt «Lifesaving – Lebensdauerverlängerung von Mobilgeräten» soll der ökologische Fussabdruck von Smartphones und anderen internetfähigen Geräten reduziert werden. 

Ende 2020 wurde eine Befragung von gut 1400 Personen durchgeführt, um mehr über Verhaltensweisen bei Smartphonekauf und -nutzung, die Motivation dahinter und den Wissensstand zu erfahren. Ein Auszug aus den Ergebnissen: 
Der grösste Teil der Befragten kauft das Smartphone neu. Technische Eigenschaften, der Preis sowie die Marke eines Gerätes sind bei der Anschaffung die zentralen Aspekte. Secondhandkäufe stellen  unter den Befragten die Ausnahme dar, doch wer einmal einen Secondhandkauf getätigt hat, ist zufrieden und würde es wieder tun. Die Weitergabe eines alten Geräts wird von mehr als der Hälfte als positiv und wichtig angesehen. Fast alle Befragten bestätigten, dies sei gut für die Umwelt. Dem Verkauf des gebrauchten Geräts gegenüber ist die Einstellung etwas weniger positiv. Vor allem die Meinungen, ein altes Gerät lasse sich noch gut zu Geld machen, Freunde befürworteten einen Verkauf bzw. ein Gerät, für das man keine Verwendung mehr hat, solle lieber verkauft werden, teilen nur etwa ein Drittel der Befragten. Von den positiven Aspekten des Weitergebens und auch des Verkaufens sind also viele der Befragten überzeugt. Dies steht im Widerspruch zum kleinen Anteil jener, die das alte Gerät effektiv verkauft oder weitergegeben haben. Die Hinderungsgründe, die von rund einem Drittel der Befragten bestätigt wurden, scheinen schwerer zu wiegen. Beim Verkauf wurden als Hinderungsgründe vor allem der Aufwand, Bedenken bezüglich persönlicher Daten auf dem Gerät angegeben, aber auch, dass sich ein mehr als zwei Jahre altes Gerät nicht mehr verkaufen lasse. Bei der Weitergabe wird der Zustand des Geräts als wichtiger empfunden als das Alter. Ebenfalls rund ein Drittel der Befragten gibt an, die auf dem Gerät gespeicherten persönlichen Daten seien ein Hinderungsgrund. Somit sind die persönlichen Daten und der Aufwand sowohl beim Verkaufen als auch bei der Weitergabe wichtige Aspekte, die viele Befragte daran hindern, ihrem alten Gerät ein zweites Leben zu ermöglichen. 
Im Rahmen der Studie wurden diverse Unterschiede zwischen den Altersgruppen identifiziert (z.B. bezüglich Kaufentscheid, Schutz- und Reparaturverhalten).
title: Формирование прав и обязанностей участкового уполномоченного полиции
Creators: name: ELS IPR BOOKS
Publisher: name: Южно-Уральский технологический университет
Year: 2022

description: В монографии на основании исторических правовых памятников исследовано формирование прав и обязанностей полиции по охране общественного порядка и общественной безопасности, приведен обзор современного законодательства, регулирующего организацию и несение службы участкового уполномоченного полиции, рассмотрены административно-правовые, уголовно-правовые, уголовно-процессуальные и иные компетенции участкового уполномоченного полиции. Монография предназначена для студентов, обучающихся по программам: 40.05.01 – Правовое обеспечение национальной безопасности; 40.05.02 – Правоохранительная деятельность; 40.05.04 – Судебная и прокурорская деятельность. Работа может быть полезной для магистрантов, аспирантов, преподавателей и научных работников, образовательных и научно-исследовательских учреждений, а также практических работников правоохранительных органов и для всех, кто интересуется данной тематикой.
Accumulation Rate of Bound States of Dipoles in Graphene
Creators: name: Rademacher, Simone
name: Siedentop, Heinz
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: 81V99

description: We prove that the bound state energies of the two-dimensional massive Dirac operator with dipole type potentials accumulate with exponentials rate at the band edge. In fact we prove a corresponding formula of De Martino et al (2014).
title: Diagnostic accuracy of bone scintigraphy, positron emission tomography/computed tomography (PET/CT) and whole body magnetic resonance imaging (MRI) in the detection of bone metastasis among patients with breast cancer using histopathologic report and / or clinical follow-up as the reference standard: A meta-analysis
Creators: name: Acayan, Emily
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Metastases
subject: Diagnostic procedure
subject: PET-CT
subject: Nuclear medicine conventional
subject: MR
subject: Oncology
subject: Breast

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: GENERAL OBJECTIVE To compare the accuracy of bone scintigraphy, PET/CT, and MRI in the diagnosis of bone metastasis. SPECIFIC OBJECTIVE To determine the sensitivity, specificy, positive likelihood ratio (PLR), negative likelihood ration...
(101572) Mary M Phillips
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Einfluss von Routine auf das Blickverhalten im Strassenverkehr
Creators: name: Amstad, Christian
name: Hackenfort, Markus
name: Diener, Sarah
name: Tsimitselis, Lambros
Publisher: name: Dike
Year: 2015
Subjects: Routine
Blickverhalten
Unfall
Verkehrssicherheit
150: Psychologie
363: Umwelt- und Sicherheitsprobleme

description: In einer Pilotstudie wurde an der Zürcher Hochschule für Angewandte Wissenschaften (ZHAW) das Blickverhalten von Fussgängern mittels mobiler Eye-Tracking-Brille untersucht. Im Fokus stand dabei die Fragestellung, ob Routine und Ablenkung dazu führen, dass sicherheitsrelevante Hinweise weniger beachtet werden. Tatsächlich führten weder die mehrmalige Exposition (Routine), noch eine kognitive Beanspruchung (Ablenkung) zu einer Veränderung der Fixationsdauer bei sicherheitsrelevanten Stimuli. Es zeigte sich stattdessen der inhaltlich positive Effekt, dass unter Ablenkung den nicht-sicherheitsrelevanten Stimuli deutlich weniger Aufmerksamkeit beigemessen wurde. Das Blickverhalten der Probanden deutet somit stark auf ein Kompensationsverhalten hin, demzufolge wegen der kognitiven Belastung versucht wird, die Sicherheit anhand einer Kompensationsstrategie möglichst aufrecht zu erhalten. Dass dies allerdings im Endeffekt tatsächlich erfolglos sein könnte, zeigte die inhaltliche Auswertung der sicherheitsrelevanten Merkmale, die Probanden verarbeiteten – bzw. nicht tiefer verarbeiteten. Diese "trügerische Sicherheit" kann sich stark unfallerhöhend auswirken. Implikationen für die Unfallforschung, beispielsweise im Kontext von so genannten "looked but failed to see"- Unfallursachen werden diskutiert.
Registration of newly released fenugreek (Trigonella foenum-graecum) variety Arganne for mid altitude of Bale, South Eastern Ethiopia
Creators: name: Getachew Asefa
name: Beriso, Mohammed
name: Getachew Asefa
name: Beriso, Mohammed
Publisher: name: Unknown
Year: 2022
Subjects: subject: Agricultural and Food Policy
subject: Crop Production/Industries
subject: Fenugreek
subject: Variety Verification
subject: Registration

description: Arganne with the accession name Acc. 202209sno3-5) is a fenugreek variety released by Oromia Agricultural Research Institute, Sinana Agricultural Research Center, Ethiopia in 2021. The trial was conducted at Sinana Agricultural Research Centre from observation nursery to preliminary yield trial and promising fenugreek genotypes were selected from yield trial based on seed yield and reaction to diseases, especially powdery mildew. These promising genotypes were evaluated against standard check Hunda’ol and Ebisa across three locations for three consecutive years (2017 to 2019). Arganne showed superior yielding ability, producing a mean seed yield of 17-26 Qt ha-1 on the research field and 15-21 Qt ha-1 on the farmers’ field. The seed yield of the new variety exceeded that of the standard check Hunda’ol and Ebisa varieties by about 12.00% and 11.23%, respectively.