cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Deep Learning applications in chest imaging of COVID-19 affected patients
Creators: name: Laino, Maria Elena
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Artificial Intelligence
subject: CT
subject: Digital radiography
subject: Plain radiographic studies
subject: CAD
subject: Computer Applications-Detection, diagnosis
subject: Diagnostic procedure
subject: Infection

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: In this exhibit, we will explore the role of Artificial Intelligence (AI) in the diagnostic imaging of patients with COVID-19 in the following domains: Identification and screening of COVID-19 pneumonia, For setting the differential diagnosis...
title: Distinguishing malignant from benign pulmonary nodules: A systematic review and meta-analysis of enhancement characteristics
Creators: name: Nawawi, Yusuf
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Lung
subject: CT
subject: Contrast agent-intravenous
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Radiological evaluation is fundamental for differentiation of benign and malignant solitary pulmonary nodules (SPNs). Several typical morphologic features may help, despite a considerable overlap between nodule types. Contrast-enhanced computed...
Characterization of an A-Kinase Anchoring Protein in Human Ciliary Axonemes
Creators: name: Byrd, Sherell K.
name: Milgram, Sharon L.
name: Kultgen, Patricia L.
name: Ostrowski, Lawrence E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Although protein kinase A (PKA) activation is known to increase ciliary beat frequency in humans the molecular mechanisms involved are unknown. We demonstrate that PKA is associated with ciliary axonemes where it specifically phosphorylates a 23-kDa protein. Because PKA is often localized to subcellular compartments in proximity to its substrate(s) via interactions with A-kinase–anchoring proteins (AKAPs), we investigated whether an AKAP was also associated with ciliary axonemes. This study has identified a novel 28 kDa AKAP (AKAP28)that is highly enriched in airway axonemes. The mRNA for AKAP28 is up-regulated as primary airway cells differentiate and is specifically expressed in tissues containing cilia and/or flagella. Additionally, both Western blot and immunostaining data show that AKAP28 is enriched in airway cilia. These data demonstrate that we have identified the first human axonemal AKAP, a protein that likely plays a role in the signaling necessary for efficient modulation of ciliary beat frequency.
MERICS EU-China Opinion Pool: EU-China relations after the Party Congress
Creators: name: Brødsgaard, Kjeld Erik
name: García-Herrero, Alicia
name: Jacoby, Marcin
name: Stec, Grzegorz
Publisher: name: Zenodo
Year: 2022
Subjects: China
EU
Party Congress
CCP
EU-China relations

description: In this round of MERICS’ EU-China opinion pool, we have asked a number of experts what the outcome of the Party Congress means for the EU and EU-China relations. The MERICS' EU-China opinion pool has received funding from the European Union’s Horizon Europe research and innovation programme under grant agreement number 101061700. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union. Neither the European Union nor the granting authority can be held responsible for them.
title: Update on radiological findings of Axial Spondyloarthritis (Spa) with emphasis in the value of T1-dixon Magnetic Resonance Imaging (MRI)
Creators: name: Morandeira Arrizabalaga, Clara
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: MR physics
subject: Musculoskeletal joint
subject: Musculoskeletal spine
subject: MR
subject: Imaging sequences
subject: Inflammation
subject: Oedema
subject: Tissue characterisation

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Review the terminology and clinical presentation of Spa and sacroiliac joints (SI) anatomy. Evaluate different MRI protocols. Examine radiological...
Dissociation of the Tubulin Dimer Is Extremely Slow, Thermodynamically Very Unfavorable, and Reversible in the Absence of an Energy Source
Creators: name: Caplow, Michael
name: Fee, Lanette
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: The finding that exchange of tubulin subunits between tubulin dimers (α-β + α′β′ ↔ α′β + αβ′) does not occur in the absence of protein cofactors and GTP hydrolysis conflicts with the assumption that pure tubulin dimer and monomer are in rapid equilibrium. This assumption underlies the many physical chemical measurements of the Kd for dimer dissociation. To resolve this discrepancy we used surface plasmon resonance to determine the rate constant for dimer dissociation. The half-time for dissociation was ∼9.6 h with tubulin-GTP, 2.4 h with tubulin-GDP, and 1.3 h in the absence of nucleotide. A Kd equal to 10−11 M was calculated from the measured rate for dissociation and an estimated rate for association. Dimer dissociation was found to be reversible, and dimer formation does not require GTP hydrolysis or folding information from protein cofactors, because 0.2 μM tubulin-GDP incubated for 20 h was eluted as dimer when analyzed by size exclusion chromatography. Because 20 h corresponds to eight half-times for dissociation, only monomer would be present if dissociation were an irreversible reaction and if dimer formation required GTP or protein cofactors. Additional evidence for a 10−11 M Kd was obtained from gel exclusion chromatography studies of 0.02–2 nM tubulin-GDP. The slow dissociation of the tubulin dimer suggests that protein tubulin cofactors function to catalyze dimer dissociation, rather than dimer assembly. Assuming N-site-GTP dissociation is from monomer, our results agree with the 16-h half-time for N-site GTP in vitro and 33 h half-life for tubulin N-site-GTP in CHO cells.
Down-Regulation of Protease-activated Receptor-1 Is Regulated by Sorting Nexin 1
Creators: name: Zhou, Yixing
name: Haft, Carol Renfrew
name: Szabo, Katalin
name: Wang, Yingjie
name: Trejo, Jo Ann
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Degradation or “down-regulation” of protease-activated receptor-1 (PAR1), a G protein-coupled receptor for thrombin, is critical for termination of receptor signaling. Toward understanding the molecular mechanisms by which activated PAR1 is internalized, sorted to lysosomes, and degraded, we investigated whether PAR1 interacted with sorting nexin 1 (SNX1). SNX1 is a membrane-associated protein that functions in lysosomal sorting of the epidermal growth factor receptor. In vitro biochemical binding assays revealed a specific interaction between a glutathione S-transferase fusion of SNX1 and PAR1. In HeLa cells, activated PAR1 colocalized with endogenous SNX1 and coimmunoprecipitated SNX1. SNX1 contains a phox homology domain predicted to bind phosphatidylinositol-3-phosphate and a C-terminal coiled-coil region. To assess SNX1 function, we examined the effects of SNX1 deletion mutants on PAR1 trafficking. Neither the N terminus nor phox homology domain of SNX1 affected PAR1 trafficking. By contrast, overexpression of SNX1 C-terminal domain markedly inhibited agonist-induced degradation of PAR1, whereas internalization remained virtually intact. Immunofluorescence microscopy studies revealed substantial PAR1 accumulation in an early endosome antigen-1-positive compartment in agonist-treated cells expressing SNX1 C terminus. By contrast, lysosome-associated membrane protein-1 distribution was unperturbed. Together, these findings strongly suggest a role for SNX1 in sorting of PAR1 from early endosomes to lysosomes. Moreover, this study provides the first example of a protein involved in lysosomal sorting of a G protein-coupled receptor in mammalian cells.
EB1 Targets to Kinetochores with Attached, Polymerizing Microtubules
Creators: name: Tirnauer, Jennifer S.
name: Mitchison, Timothy J.
name: Salmon, E. D.
name: Canman, Julie C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Microtubule polymerization dynamics at kinetochores is coupled to chromosome movements, but its regulation there is poorly understood. The plus end tracking protein EB1 is required both for regulating microtubule dynamics and for maintaining a euploid genome. To address the role of EB1 in aneuploidy, we visualized its targeting in mitotic PtK1 cells. Fluorescent EB1, which localized to polymerizing ends of astral and spindle microtubules, was used to track their polymerization. EB1 also associated with a subset of attached kinetochores in late prometaphase and metaphase, and rarely in anaphase. Localization occurred in a narrow crescent, concave toward the centromere, consistent with targeting to the microtubule plus end–kinetochore interface. EB1 did not localize to kinetochores lacking attached kinetochore microtubules in prophase or early prometaphase, or upon nocodazole treatment. By time lapse, EB1 specifically targeted to kinetochores moving antipoleward, coupled to microtubule plus end polymerization, and not during plus end depolymerization. It localized independently of spindle bipolarity, the spindle checkpoint, and dynein/dynactin function. EB1 is the first protein whose targeting reflects kinetochore directionality, unlike other plus end tracking proteins that show enhanced kinetochore binding in the absence of microtubules. Our results suggest EB1 may modulate kinetochore microtubule polymerization and/or attachment.
Gauge Physics of Spin Hall Effect
Creators: name: Tan, Seng Ghee
name: Jalil, Mansoor B. A.
name: Ho, Congson
name: Siu, Zhuobin
name: Murakami, Shuichi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Spin Hall effect (SHE) has been discussed in the context of Kubo formulation, geometric physics, spin orbit force, and numerous semi-classical treatments. It can be confusing if the different pictures have partial or overlapping claims of contribution to the SHE. In this article, we present a gauge-theoretic, time-momentum elucidation, which provides a general SHE equation of motion, that unifies under one theoretical framework, all contributions of SHE conductivity due to the kinetic, the spin orbit force (Yang-Mills), and the geometric (Murakami-Fujita) effects. Our work puts right an ambiguity surrounding previously partial treatments involving the Kubo, semiclassical, Berry curvatures, or the spin orbit force. The full treatment shows the Rashba 2DEG SHE conductivity to be +e/8π instead of -e/8π , and Rashba heavy hole +9e/8π instead of -9e/8π .
description: 14 pages, 2 figures, 1 table
title: Immunotherapy and imaging: A changing challenge for a correct interpretation
Creators: name: GARRIGA, victoria
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Nuclear medicine
subject: Oncology
subject: CT
subject: MR
subject: PET-CT
subject: Structured reporting
subject: Cancer

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To review the types of immunotherapy and their mechanisms of action. To describe response patterns including pseudoprogression, dissociated response, hyperprogression, and abscopal effect. To describe the radiographic appearance of potiental adverse...
MERICS EU-China Opinion Pool: Calibrating interdependence with China
Creators: name: Wuttke, Jörg
name: Santos, Luisa
name: Strack, Friedolin
name: Matthes, Jürgen
name: Ghiretti, Francesca
name: Chimits, François
Publisher: name: Zenodo
Year: 2023
Subjects: China
EU
EU-China relations
Supply-chain risks
Diversification

description: One of the EU’s most heated current debates about China concerns the question of how to reduce risks arising from interdependencies with the country. Business leaders and politicians in Europe are now discussing options to ensure competitiveness and economic resilience. In this round of MERICS’ EU-China opinion pool, the Mercator Institute for China Studies (MERICS) has asked experts: “Calibrating interdependence with China - how should the EU proceed?” The MERICS' EU-China opinion pool has received funding from the European Union’s Horizon Europe research and innovation programme under grant agreement number 101061700. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union. Neither the European Union nor the granting authority can be held responsible for them.
(401630) John Colin Mitchell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Imaging review of Surface Osteosarcomas
Creators: name: Matellini Mosca, Briano
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Musculoskeletal bone
subject: Oncology
subject: Conventional radiography
subject: CT
subject: MR
subject: Diagnostic procedure
subject: Education
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To describe the epidemiological characteristics of the patients diagnosed with surface osteosarcomas in our centre. To highlight the distinct imaging findings of parosteal, periosteal and high grade surface osteosarcoma. To correlate imaging and...
Genetic Ablation of Phosphatidylinositol Transfer Protein Function in Murine Embryonic Stem Cells
Creators: name: Cui, Xiaoxia
name: Pinxteren, Jef
name: Bankaitis, Vytas A.
name: Sontheimer, Harald
name: York, John D.
name: Cotlin, Laura
name: Manning, Timothy
name: Guo, Shuling
name: Phillips, Scott E.
name: Collawn, James F.
name: Alb Jr., James G.
name: Rostand, Kathleen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Phosphatidylinositol transfer proteins (PITPs) regulate the interface between signal transduction, membrane-trafficking, and lipid metabolic pathways in eukaryotic cells. The best characterized mammalian PITPs are PITPα and PITPβ, two highly homologous proteins that are encoded by distinct genes. Insights into PITPα and PITPβ function in mammalian systems have been gleaned exclusively from cell-free or permeabilized cell reconstitution and resolution studies. Herein, we report for the first time the use of genetic approaches to directly address the physiological functions of PITPα and PITPβ in murine cells. Contrary to expectations, we find that ablation of PITPα function in murine cells fails to compromise growth and has no significant consequence for bulk phospholipid metabolism. Moreover, the data show that PITPα does not play an obvious role in any of the cellular activities where it has been reconstituted as an essential stimulatory factor. These activities include protein trafficking through the constitutive secretory pathway, endocytic pathway function, biogenesis of mast cell dense core secretory granules, and the agonist-induced fusion of dense core secretory granules to the mast cell plasma membrane. Finally, the data demonstrate that PITPα-deficient cells not only retain their responsiveness to bulk growth factor stimulation but also retain their pluripotency. In contrast, we were unable to evict both PITPβ alleles from murine cells and show that PITPβ deficiency results in catastrophic failure early in murine embryonic development. We suggest that PITPβ is an essential housekeeping PITP in murine cells, whereas PITPα plays a far more specialized function in mammals than that indicated by in vitro systems that show PITP dependence.
A study on the interdependency of hydroponic wastewater quality and the energy and costs for onsite treatment
Creators: name: Rose, Heather
Publisher: name: The University of Texas at Austin
Year: 2020
Subjects: Hydroponic wastewater
Onsite water treatment

description: Hydroponic growing methods have the potential to use less water while producing higher yields when compared to traditional soil-based agriculture. However, hydroponic wastewater is a nutrient dense effluent that can be harmful to the environment if not managed properly. Onsite treatment and reuse of hydroponic wastewater would avoid thousands of gallons a month of freshwater use while preventing this effluent from harming receiving streams. The efficacy, energy requirements and costs of some treatment methods are not well known. To assess the efficacy of select treatment methods, the contaminants in hydroponic wastewater were measured using samples of hydroponic wastewater collected from a greenhouse test facility and analyzed by an environmental laboratory. Contaminants evaluated were Total Dissolved Solids (TDS), calcium, potassium, magnesium, total phosphorus, nitrogen, and Total Organic Carbon (TOC). Wastewater samples were also treated onsite using a sand filter, a granular activated carbon (GAC) filter, and reverse osmosis (RO). Samples of wastewater treated by these methods were then re-analyzed by the environmental laboratory and post-treatment concentrations of the studied contaminants were recorded. Sand and GAC filtration were shown to be essentially ineffective for contaminant removal due to the high concentrations of metals in the hydroponic wastewater. Reverse osmosis was the most effective treatment method, removing an average of 85% TDS concentration in wastewater samples. The results from the water quality analysis showed that Reverse Osmosis was the only treatment method that effectively removed the large concentration of metal contaminants in the wastewater. For this reason, only reverse osmosis was analyzed for energy and cost requirements for onsite treatment of hydroponic wastewater. The energy requirements to treat hydroponic wastewater onsite by reverse osmosis ranged from 3 to 43 kWh per day, depending on the facility size and percent of water treated. The annualized cost of treatment ranged from $0.63 to $2.83 per thousand gallons of water treated. Finally, a cost savings from reduced water bills analysis was also performed using local water utility prices in Austin TX. Based on the assumptions made for water meter size and monthly water use, it was found that financial savings could be achieved in all facility sizes with a payback period of 7 to 24 months if facilities utilized municipal water as their water source. These results can help to determine whether recycling hydroponic wastewater is feasible within financial and energy constraints as a way to avoid discharging harmful effluent and using thousands of gallons of source water each month.
GMCs scaling relations: role of the cloud definition
Creators: name: Khoperskov, S. A.
name: Vasiliev, E. O.
name: Ladeyschikov, D. A.
name: Sobolev, A. M.
name: Khoperskov, A. V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We investigate physical properties of molecular clouds in disc galaxies with different morphology: a galaxy without prominent structure, a spiral barred galaxy and a galaxy with flocculent structure. Our $N$-body/hydrodynamical simulations take into account non-equilibrium H$_2$ and CO chemical kinetics, self-gravity, star formation and feedback processes. For the simulated galaxies the scaling relations of giant molecular clouds or so called Larson's relations are studied for two types of a cloud definition (or extraction methods): the first one is based on total column density position-position (PP) datasets and the second one is indicated by the CO~(1-0) line emission used position-position-velocity (PPV) data. We find that the cloud populations obtained by using both cloud extraction methods generally have similar physical parameters. Except that for the CO data the mass spectrum of clouds has a tail with low-massive objects $M\sim 10^3-10^4$~\Msun. Varying column density threshold the power-law indices in the scaling relations are significantly changed. In contrast, the relations are invariant to CO brightness temperature threshold. Finally, we find that the mass spectra of clouds for the PPV data are almost insensitive to the galactic morphology, whereas the spectra for the PP data demonstrate significant variations.
description: Accepted for publication in MNRAS, 16 pages, 9 figures
(401627) John Gillon
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Effectiveness of a teaching intervention on chest radiograph understanding and request quality in COVID-19 infection at a medium sized UK district general hospital
Creators: name: Colman, Jordan
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Lung
subject: Thorax
subject: Plain radiographic studies
subject: Audit and standards
subject: Education
subject: Education and training

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Purpose In the UK CXRs are typically the first radiological investigation used to stratify the risk of COVID-19 infection. CXRs can additionally be graded for the severity of known or suspected COVID-19 infection as recommended by the BSTI [1]....
Genetic Analysis of Sorting Nexins 1 and 2 Reveals a Redundant and Essential Function in Mice
Creators: name: Griffin, Courtney T.
name: Schneider, Elizabeth A.
name: Magnuson, Terry
name: Schwarz, Dana Gilbert
name: Yee, Della
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Sorting nexins 1 (Snx1) and 2 (Snx2) are homologues of the yeast gene VPS5 that is required for proper endosome-to-Golgi trafficking. The prevailing thought is that Vps5p is a component of a retrograde trafficking complex called the retromer. Genetic and biochemical evidence suggest mammals may have similar complexes, but their biological role is unknown. Furthermore, if SNX1 and SNX2 belong to such complexes, it is not known whether they act together or separately. Herein, we show that mice lacking SNX1 or SNX2 are viable and fertile, whereas embryos deficient in both proteins arrest at midgestation. These results demonstrate that SNX1 and SNX2 have a highly redundant and necessary function in the mouse. The phenotype of Snx1-/-;Snx2-/- embryos is very similar to that of embryos lacking another retromer homologue, Hβ58. This finding suggests that SNX1/SNX2 and Hβ58 function in the same genetic pathway, providing additional evidence for the existence of mammalian complexes that are structurally similar to the yeast retromer. Furthermore, the viability of Snx1-/- and Snx2-/- mice demonstrates that it is not necessary for SNX1 and SNX2 to act together. Electron microscopy indicates morphological alterations of apical intracellular compartments in the Snx1-/-;Snx2-/- yolk-sac visceral endoderm, suggesting SNX1 and SNX2 may be required for proper cellular trafficking. However, tetraploid aggregation experiments suggest that yolk sac defects cannot fully account for Snx1-/-; Snx2-/- embryonic lethality. Furthermore, endocytosis of transferrin and low-density lipoprotein is unaffected in mutant primary embryonic fibroblasts, indicating that SNX1 and SNX2 are not essential for endocytosis in all cells. Although the two proteins demonstrate functional redundancy, Snx1+/-;Snx2-/- mice display abnormalities not observed in Snx1-/-;Snx2+/- mice, revealing that SNX1 and SNX2, or their genetic regulation, are not equivalent. Significantly, these studies represent the first mutations in the mammalian sorting nexin gene family and indicate that sorting nexins perform essential functions in mammals.
(401628) John Pendergast
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Tumor-like lesions of the testis in adults: pictorial review
Creators: name: Pérez, Irune
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Genital / Reproductive system male
subject: MR
subject: Ultrasound
subject: Diagnostic procedure
subject: Pathology

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: - US is the imaging modality of choice for initial evaluation of scrotal pathologic conditions (Image 1). -Some benign testicular masses can be easily recognized, obviating orchiectomy. -Some other benign lesions/ testicular conditions may be...
title: Differentiating glioblastom lesions from other intracranial soliter lesions: Nonenhancing Peritumoral Hyperintense Gyral Lesion on T2 FLAIR imaging and DWI
Creators: name: Günay, Burak
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Neuroradiology brain
subject: MR
subject: MR-Diffusion/Perfusion
subject: Imaging sequences
subject: Cancer
subject: Lymphoma
subject: Metastases

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Glioblastoma is the most common type of malignant primary brain tumor, and methods to improve early detection and treatment response are highly coveted. At the same time, although it has radiological features that are difficult to distinguish from...
Identification of Genes Periodically Expressed in the Human Cell Cycle and Their Expression in Tumors
Creators: name: Ball, Catherine A.
name: Matese, John C.
name: Alexander, Karen E.
name: Hurt, Myra M.
name: Murray, John I.
name: Saldanha, Alok J.
name: Perou, Charles M.
name: Brown, Patrick O.
name: Botstein, David
name: Whitfield, Michael L.
name: Sherlock, Gavin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: The genome-wide program of gene expression during the cell division cycle in a human cancer cell line (HeLa) was characterized using cDNA microarrays. Transcripts of >850 genes showed periodic variation during the cell cycle. Hierarchical clustering of the expression patterns revealed coexpressed groups of previously well-characterized genes involved in essential cell cycle processes such as DNA replication, chromosome segregation, and cell adhesion along with genes of uncharacterized function. Most of the genes whose expression had previously been reported to correlate with the proliferative state of tumors were found herein also to be periodically expressed during the HeLa cell cycle. However, some of the genes periodically expressed in the HeLa cell cycle do not have a consistent correlation with tumor proliferation. Cell cycle-regulated transcripts of genes involved in fundamental processes such as DNA replication and chromosome segregation seem to be more highly expressed in proliferative tumors simply because they contain more cycling cells. The data in this report provide a comprehensive catalog of cell cycle regulated genes that can serve as a starting point for functional discovery. The full dataset is available at http://genome-www.stanford.edu/Human-CellCycle/HeLa/.
Biochemical basis of activation and inhibition of an NLR/PRR immune receptor network
Creators: name: Contreras, Mauricio P.
name: Pai, Hsuan
name: Selvaraj, Muniyandi
name: Toghani, AmirAli
name: Tumtas, Yasin
name: Yuen, Enoch L. H.
name: Duggan, Cian
name: Ahn, Hee-Kyung
name: Kourelis, Jiorgos
name: Harant, Adeline
name: Wu, Chih-Hang
name: Bozkurt, Tolga O.
name: Derevnina, Lida
name: Kamoun, Sophien
Publisher: name: Zenodo
Year: 2023
Subjects: Plant Immunity, NLR, bioengineering, nematode

description: The plant immune system utilizes intracellular nucleotide-binding domain and leucine-rich repeat (NLR) receptors to recognize and respond to pathogen-secreted proteins, termed effectors. NLRs can function individually or in higher-order configurations, such as pairs or networks. In solanaceous plants, the NLR- required for cell death (NRC) network is a complex NLR network that mediates resistance against diverse pathogens by connecting sensor NLRs and cell surface receptors to helper NLRs of the NRC clade. While the genetics underlying the NRC network are well characterized, until recently, our understanding of the biochemical mechanisms of activation in this network were limited. We established native PAGE electrophoresis using the NRC-dependent sensor NLR Rx and its helper NRCs as an experimental system to study the activation mechanisms of the NRC network. We report that upon pathogen perception, Rx mediates the formation of NRC homo-oligomers. The activated NRC resistosomes then accumulate at the plant plasma membrane without the sensor NLR Rx. Additionally, we discovered that the previously characterized nematode effector SPRYSEC15, which suppresses NRC function, can inhibit NRC2 oligomerization and plasma membrane association to prevent immune signaling. To overcome this suppression, we bioengineered an NRC2 variant that is resilient to this inhibition and capable of restoring immune signalling. Our work establishes an activation-and-release model for sensor-helper activation of NLRs in the NRC network and leverages this understanding to bioengineer disease resistance.
(401623) Helen Jobson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Transitional criminal justice in Spain
Creators: name: Salsench Linares, Samantha
Publisher: name: Humboldt-Universität zu Berlin
Year: 2023
Subjects: subject: Spanischer Bürgerkrieg
subject: Franco
subject: Verschwinden lassen
subject: Amnestie
subject: Übergang
subject: Übergangsjustiz
subject: Legalitätsprinzip
subject: Verjährung
subject: verjährt
subject: Dauerdelikt
subject: Wahrheitsfindung
subject: Wahrheitssuche
subject: Straflosigkeit
subject: Kriegsverbrechen
subject: Verbrechen gegen die Menschlichkeit
subject: Vergangenheitsbewältigung
subject: Vergangenheitsaufarbeitung
subject: Rückwirkung
subject: rückwirkend
subject: Spanish Civil War
subject: Enforced disappearance
subject: Amnesty
subject: Transition
subject: Transitional justice
subject: principle of legality
subject: limitation period
subject: Statutory limitation
subject: time-barred
subject: permanent crime
subject: continuous crime
subject: truth-telling
subject: truth-finding
subject: impunity
subject: war crime
subject: crime against humanity
subject: accountability
subject: coming to terms with the past
subject: retroactive
subject: 345 Strafrecht
subject: 341 Völkerrecht
subject: Amnistía
subject: Prescripción
subject: Desaparición forzada
subject: Delito permanente
subject: Principio de legalidad
subject: retroactividad
subject: Justicia transicional
subject: PH 6244

description: Diese Arbeit befasst sich mit den Fällen von Repression, die während des Spanischen Bürgerkriegs 1936-1939 und der franquistischen Diktatur stattfanden und die seit den 2000er Jahren vor Gericht gebracht wurden. Im ersten Teil der Arbeit werden diese Fälle unter spanisches Strafrecht subsumiert. Im zweiten Teil der Arbeit wird untersucht, ob das vom spanischen Parlament im Oktober 1977 verabschiedete Amnestiegesetz mit den internationalen Menschenrechtsnormen vereinbar ist. Schließlich werden im dritten Teil der Arbeit die Fälle aus der Zeit des Spanischen Bürgerkriegs 1936-1939 nach internationalem Strafrecht und humanitärem Recht analysiert.
description: This work deals with the cases of repression that occurred during the 1936-1939 Spanish Civil War and the Francoist dictatorship and that have been brought to court since the 2000s. A first part of the work has subsumed these cases under Spanish domestic criminal law. A second part of the work examines the compliance of the amnesty law enacted by the Spanish Parliament in October 1977 with International Human Rights Law. Finally, a third part of the work analyses the cases occurred during the 1936-1939 Spanish Civil War under international criminal and humanitarian law.
title: Evaluation of risk factors and imaging characteristics in cervico-cerebral artery dissection
Creators: name: Opancina, Valentina
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Interventional vascular
subject: Neuroradiology brain
subject: Vascular
subject: Catheter arteriography
subject: CT-Angiography
subject: MR-Angiography
subject: Angioscopy
subject: Diagnostic procedure
subject: Statistics
subject: FOS: Mathematics
subject: Dissection
subject: Education and training
subject: Ischaemia / Infarction

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: The purpose of our study is to report our experience hilightening risk factors and imaging characteristics of cervico-cerebral artery...
Kar9p-independent Microtubule Capture at Bud6p Cortical Sites Primes Spindle Polarity before Bud Emergence in Saccharomyces cerevisiae
Creators: name: Reed, Steven I.
name: Segal, Marisa
name: Bloom, Kerry
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: Spindle orientation is critical for accurate chromosomal segregation in eukaryotic cells. In the yeast Saccharomyces cerevisiae, orientation of the mitotic spindle is achieved by a program of microtubule–cortex interactions coupled to spindle morphogenesis. We previously implicated Bud6p in directing microtubule capture throughout this program. Herein, we have analyzed cells coexpressing GFP:Bud6 and GFP:Tub1 fusions, providing a kinetic view of Bud6p–microtubule interactions in live cells. Surprisingly, even during the G1 phase, microtubule capture at the recent division site and the incipient bud is dictated by Bud6p. These contacts are eliminated in bud6Δ cells but are proficient in kar9Δ cells. Thus, Bud6p cues microtubule capture, as soon as a new cell polarity axis is established independent of Kar9p. Bud6p increases the duration of interactions and promotes distinct modes of cortical association within the bud and neck regions. In particular, microtubule shrinkage and growth at the cortex rarely occur away from Bud6p sites. These are the interactions selectively impaired at the bud cortex in bud6Δ cells. Finally, interactions away from Bud6p sites within the bud differ from those occurring at the mother cell cortex, pointing to the existence of an independent factor controlling cortical contacts in mother cells after bud emergence.
Campbell penetration in the critical state of type-II superconductors
Creators: name: Willa, R.
name: Geshkenbein, V. B.
name: Blatter, G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: The penetration of an $ac$ magnetic signal into a type II superconductor residing in the Shubnikov phase depends on the pinning properties of Abrikosov vortices. Within a phenomenological theory, the so-called Campbell penetration depth $λ_{\rm \scriptscriptstyle C}$ is determined by the curvature $α$ at the bottom of the effective pinning potential. Preparing the sample into a Bean critical state, this curvature vanishes and the Campbell length formally diverges. We make use of the microscopic expression for the pinning force density derived within strong pinning theory and show how flux penetration on top of a critical state proceeds in a regular way.
description: 8 pages, 6 figures
Mad2 and BubR1 Function in a Single Checkpoint Pathway that Responds to a Loss of Tension
Creators: name: Canman, Julie C.
name: Shannon, Katie B.
name: Salmon, E. D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: The spindle checkpoint monitors microtubule attachment and tension at kinetochores to ensure proper chromosome segregation. Previously, PtK1 cells in hypothermic conditions (23°C) were shown to have a pronounced mitotic delay, despite having normal numbers of kinetochore microtubules. At 23°C, we found that PtK1 cells remained in metaphase for an average of 101 min, compared with 21 min for cells at 37°C. The metaphase delay at 23°C was abrogated by injection of Mad2 inhibitors, showing that Mad2 and the spindle checkpoint were responsible for the prolonged metaphase. Live cell imaging showed that kinetochore Mad2 became undetectable soon after chromosome congression. Measurements of the stretch between sister kinetochores at metaphase found a 24% decrease in tension at 23°C, and metaphase kinetochores at 23°C exhibited higher levels of 3F3/2, Bub1, and BubR1 compared with 37°C. Microinjection of anti-BubR1 antibody abolished the metaphase delay at 23°C, indicating that the higher kinetochore levels of BubR1 may contribute to the delay. Disrupting both Mad2 and BubR1 function induced anaphase with the same timing as single inhibitions, suggesting that these checkpoint genes function in the same pathway. We conclude that reduced tension at kinetochores with a full complement of kinetochore microtubules induces a checkpoint dependent metaphase delay associated with elevated amounts of kinetochore 3F3/2, Bub1, and BubR1 labeling.
title: ÐÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½ÑÐ¹ Ð¿Ð°ÐºÐµÑ Ð´Ð»Ñ Ð¿ÐµÑÐµÐ²Ð¾Ð´Ð° Ð²ÑÑÐ°Ð¶ÐµÐ½Ð¸Ð¹ ÑÐµÐ»ÑÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ Ð°Ð»Ð³ÐµÐ±ÑÑ Ð½Ð° ÑÐ·ÑÐº SQL Ð´Ð»Ñ Ð¡Ð£ÐÐ Oracle Ð¸ Postgres
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Program package for translating relational algebra expressions into SQL language for Oracle and Postgres databases
Creators: name: ÐÑÐµÐ½Ð¸ÑÐ½Ð¸ÐºÐ¾Ð²Ð°, ÐÐ¸Ð°Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: ÑÐµÐ»ÑÑÐ¸Ð¾Ð½Ð½Ð°Ñ Ð°Ð»Ð³ÐµÐ±ÑÐ°
ÑÑÐ°Ð½ÑÐ»ÑÑÐ¾Ñ
ÑÑÐµÐ½Ð°Ð¶ÐµÑ
SQL-Ð·Ð°Ð¿ÑÐ¾Ñ
relational algebra
translator
simulator
SQL-query

description: Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð¸Ð·Ð»Ð¾Ð¶ÐµÐ½ Ð¿ÑÐ¾ÑÐµÑÑ ÑÐ¾Ð·Ð´Ð°Ð½Ð¸Ñ Ð¸ ÑÐµÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½ÑÑ Ð¿Ð°ÐºÐµÑÐ¾Ð² Ð¿Ð¾ Ð¿ÑÐ¾Ð²ÐµÑÐºÐµ ÑÐµÑÐµÐ½Ð¸Ñ Ð·Ð°Ð´Ð°Ñ Ð¿Ð¾ ÑÐµÐ»ÑÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ Ð°Ð»Ð³ÐµÐ±ÑÐµ Ð½Ð° ÑÐ·ÑÐºÐ°Ñ Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ñ PL/SQL Oracle Ð¸ PL/pgSQL Postgres. ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½ Ð°Ð½Ð°Ð»Ð¸Ð· Ð¾Ð¿ÐµÑÐ°ÑÐ¸Ð¹ ÑÐµÐ»ÑÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ Ð°Ð»Ð³ÐµÐ±ÑÑ. ÐÐ·ÑÑÐµÐ½Ñ ÑÑÑÐµÑÑÐ²ÑÑÑÐ¸Ðµ ÑÐ¿Ð¾ÑÐ¾Ð±Ñ ÑÑÐ°Ð½ÑÐ»ÑÑÐ¸Ð¸ Ð¾Ð¿ÐµÑÐ°ÑÐ¸Ð¹ ÑÐµÐ»ÑÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ Ð°Ð»Ð³ÐµÐ±ÑÑ Ð½Ð° ÑÐ·ÑÐº SQL Ð¸ ÑÑÑÐµÑÑÐ²ÑÑÑÐ¸Ðµ Ð¾ÑÐºÑÑÑÑÐµ ÑÑÐµÐ½Ð°Ð¶ÐµÑÑ Ð¿Ð¾ ÑÐµÑÐµÐ½Ð¸Ñ Ð·Ð°Ð´Ð°Ñ Ð¿Ð¾ ÑÐµÐ»ÑÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ Ð°Ð»Ð³ÐµÐ±ÑÐµ. Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½ Ð¸ ÑÐµÐ°Ð»Ð¸Ð·Ð¾Ð²Ð°Ð½ Ð°Ð»Ð³Ð¾ÑÐ¸ÑÐ¼ Ð¿ÑÐ¾Ð²ÐµÑÐºÐµ Ð·Ð°Ð´Ð°Ñ Ð¿Ð¾ ÑÐµÐ»ÑÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ Ð°Ð»Ð³ÐµÐ±ÑÐµ Ð½Ð° Ð´Ð²ÑÑ ÑÐ·ÑÐºÐ°Ñ.
description: This paper describes the process of creating and testing software packages to verify the solution of relational algebra problems in the programming languages PL/SQL Oracle and PL/pgSQL Postgres. The analysis of relational algebra operations is carried out. The existing ways of translating relational algebra operations into SQL and existing open simulators for solving relational algebra problems are studied. An algorithm for checking relational algebra problems in two languages has been developed and implemented.
(401624) Robert Scott
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
ISTIROHAT  BOG'LARINI KO'KALAMZORLASHTIRISHDA KLUMBA RABATKA ALLEYA  USULLARIDAN FOYDALANIB  LANDSHAFT  DIZAYN YARATISH
Creators: name: Zokirov, Dostonbek
name: Sirojiddinov, Begzod
name: Abidov, Baxtiyor
Publisher: name: Zenodo
Year: 2023

description: Ushbu tezisda, istirohat bog'larini ko'kalamzorlashtirishda Klumba Rabatka Alleya usullaridan foydalanib landshaft dizayn yaratish haqida fikr va mulohazalar yuritiladi. Bog'lar tabiat va san'at o'zaro bog'langan.  Ularni ko'rganlarning barchasiga tasalli va ilhom baxsh etadi. Peyzaj dizayni - bu tabiiy elementlarning uyg'un kombinatsiyasi va ijodiy zukkolik. So'nggi yillarda Klumba Rabatka Alley usullari bog'ni ko'kalamzorlashtirish dunyosida mashhur bo'lib, tashqi makonni idrok etish uslubimizni inqilob qildi. Landshaft dizaynining murakkab dunyosini Klumba Rabatka Alley usullarining nuanslarini  va ular oddiy bog'larni qanday qilib g'ayrioddiy san'at asarlariga aylantiradi.
Linear conic formulations for two-party correlations and values of nonlocal games
Creators: name: Sikora, Jamie
name: Varvitsiotis, Antonios
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optimization and Control (math.OC)
subject: Quantum Physics (quant-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: In this work we study the sets of two-party correlations generated from a Bell scenario involving two spatially separated systems with respect to various physical models. We show that the sets of classical, quantum, no-signaling and unrestricted correlations can be expressed as projections of affine sections of appropriate convex cones. As a by-product, we identify a spectrahedral outer approximation to the set of quantum correlations which is contained in the first level of the Navascués, Pironio and Acín (NPA) hierarchy and also a sufficient condition for the set of quantum correlations to be closed. Furthermore, by our conic formulations, the value of a nonlocal game over the sets of classical, quantum, no-signaling and unrestricted correlations can be cast as a linear conic program. This allows us to show that a semidefinite programming upper bound to the classical value of a nonlocal game introduced by Feige and Lovász is in fact an upper bound to the quantum value of the game and moreover, it is at least as strong as optimizing over the first level of the NPA hierarchy. Lastly, we show that deciding the existence of a perfect quantum (resp. classical) strategy is equivalent to deciding the feasibility of a linear conic program over the cone of completely positive semidefinite matrices (resp. completely positive matrices). By specializing the results to synchronous nonlocal games, we recover the conic formulations for various quantum and classical graph parameters that were recently derived in the literature.
description: Accepted version. 30 pages, improved presentation, results unchanged. Includes an appendix on constraint satisfaction problems
Mammalian Septins Nomenclature
Creators: name: Zeleznik-Le, Nancy J.
name: Ware, Jerry
name: Roth, Dagmar
name: Field, Christine M.
name: Kinoshita, Makoto
name: Glotzer, Michael
name: Maltais, Lois J.
name: Tanaka, Manami
name: Zieger, Barbara
name: Stuhlmann, Heidi
name: Petty, Elizabeth M.
name: Kennedy, Mary B.
name: Mitchison, Timothy J.
name: Tanaka, Tomoo
name: Baldarelli, Richard
name: Hayashi, Yasuhide
name: Noda, Makoto
name: McKenzie, Louise
name: Pringle, John R.
name: Hsu, Shu Chan
name: Trimble, William S.
name: Nishikawa, Toru
name: Peifer, Mark
name: Hilary Russell, S. E.
name: Robinson, Phillip J.
name: Longtine, Mark
name: Low, Claudia
name: Macara, Ian G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2002

description: There are 10 known mammalian septin genes, some of which produce multiple splice variants. The current nomenclature for the genes and gene products is very confusing, with several different names having been given to the same gene product and distinct names given to splice variants of the same gene. Moreover, some names are based on those of yeast or Drosophila septins that are not the closest homologues. Therefore, we suggest that the mammalian septin field adopt a common nomenclature system, based on that adopted by the Mouse Genomic Nomenclature Committee and accepted by the Human Genome Organization Gene Nomenclature Committee. The human and mouse septin genes will be named SEPT1–SEPT10 and Sept1–Sept10, respectively. Splice variants will be designated by an underscore followed by a lowercase “v” and a number, e.g., SEPT4_v1.