cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Certain characteristics of iSchools compared to other LIS programs
Creators: name: Wedgeworth, Robert
Publisher: name: No Publisher Supplied
Year: 2013

description: This dissertation compares 17 iSchools and 36 other LIS schools that offer the ALA-accredited Master’s degree program according to certain characteristics.  The study compiles quantitative and qualitative data on 32 variables and sub-variables drawn from the schools’ web sites, ALISE 2010 Statistical Report, and Elsevier’s SCOPUS database.  The variables include size of FTE faculty, size of FTE ALA Master’s degree enrollment, total school income, total school external income, types of courses in the ALA Master’s program, types of research degrees held by full-time professorial faculty, quantity of research by full-time professorial faculty, the range of journals in which faculty research was published, and the level of journal cocitation among the full-time professorial faculty.  Statistical analysis of the data using t-tests and logistic regression tests reveal significant differences between the iSchools and the other LIS schools that offer the ALA Master’s degree.  This dissertation raises more questions than it answers, but it does lay a foundation of basic information about iSchools and other LIS programs that will contribute to the search for a precise iSchool identity.
Ancistrobasis Dall 1889
Creators: name: Ortega, José Rafael
name: Gofas, Serge
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Seguenziida
Seguenziidae
Ancistrobasis

description: Genus Ancistrobasis Dall, 1889
TYPE SPECIES. — Basilissa costulata R. B. Watson, 1879, by monotypy.
description: Published as part of Ortega, José Rafael & Gofas, Serge, 2019, The unknown bathyal of the Canaries: new species and new records of deep-sea Mollusca, pp. 513-551 in Zoosystema 41 (26) on page 522, DOI: 10.5252/zoosystema2019v41a26, http://zenodo.org/record/3726028
Natural Products for the Treatment of Never Smoker Lung Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Lung cancer arising in never smokers, those that have smoker less than 100 cigarettes in a lifetime, represent ~15-20% of all new lung cancer cases in the USA. These cancers are responsible for ~300,000 deaths annually world-wide, with an increased incidence in women and those of East Asian origin. Genome wide studies have shown that tumors from patients that have never smoked have significantly fewer mutations than lung cancers arising in smokers, however, many of these mutations are in key driver genes that could be targeted. To that end, we are using a panel of non-small cell lung cancer cell lines that are derived from patients in the never smoker classification and have molecular signatures of never smoker lung cancer to discover novel therapeutics to target these tumors. Our approach is to use a library of natural products from marine-derived bacteria, a rich resource of unique chemistry, coupled with the never smoker lung cancer cell lines to probe therapeutic chemical/biological interactions. We have already screened 8,000 natural product fractions against four of these never smoker cell lines to identify promising biological signatures. We will progress active natural products through a series of biological assays, mechanism of action studies and bioinformatics to provide a link between a chemical and a genetic biomarker to predict sensitivity. The results from these studies will be disseminated to the academic and clinical community as well as to the general public as appropriate.
Sense of entitlement and dating abusive behavior in college dating relationships
Creators: name: Warrener, Corinne Dubroca
Publisher: name: No Publisher Supplied
Year: 2013

description: The current study sought to explore the relationships between sense of entitlement, gender, and abusive behaviors among dating relationships in the emerging adulthood phase.  The existing literature around abusive behaviors suggests differences in patterns, motivations, and use of abusive behaviors by gender (Konrath, Bushman, & Campbell, 2006; Luthra & Gidycz, 2006; Stark, 2009; Straus, 2004).  Self-Salience Theory provides a foundation for understanding the interaction of gender and abusive behaviors, while also suggesting that sense of entitlement (or the act of privileging oneself over a partner) is a key component in motivation for abusive behaviors (Rosenfield, Vertefeuille, & McAlpine, 2000).  The current study examined gender differences in entitlement and abuse and investigated whether sense of entitlement is a good explanatory variable for abusive behavior.  Data were collected from the study body of a private university in New Jersey and the subsample of 18-25 year olds in dating relationships was used for the analysis.   The survey was conducted during the 2011-2012 school year and collected responses anonymously online.  Bivariate and multivariate analyses did not find significant differences in rates of abuse by gender, but did find that sense of entitlement is a better predictor of men’s behavior than women’s behavior.  Sense of entitlement explains a small amount of the variance for abusive behavior in the sample that included men and women; it explained little to no variance in the women’s subsample while explaining a much greater amount of the variance in the men’s subsample.  Hierarchical regression determined that the interaction between gender and sense of entitlement is an important factor in explaining abusive behavior.  The following dissertation reviews the relevant literature, including a background on dating violence, abusive behaviors, entitlement, theory, and current debates over gender in the dating violence literature.  The dissertation will provide an in-depth review of data collection methods and the statistical analyses used to explore the relationships between gender, sense of entitlement, and abuse.  The final chapter reviews the results, implications, limitations, and conclusions of the study.
Oxidative addition to iridium(I) complexes
Creators: name: Wang, David Yu-Ber
Publisher: name: No Publisher Supplied
Year: 2013

description: Understanding the fundamental processes underlying the activation of small molecules by metal complexes is a continuing goal of organometallic chemistry.  This thesis aims to better understand the processes and interactions of small molecules with organometallic complexes.     DFT calculations were performed on an extensive series of (PH3)2IrX complexes to investigate the thermodynamics of C-H and N-H oxidative addition.  Electronic substituent effects were decomposed into their σ and π effects and individually parameterized; the resulting σX and πX parameters were used to fit the energies of oxidative addition of methane to a series of 3- and 4-coordinate Ir(I) complexes.  Regression analysis indicates that oxidative addition of methane to 3-coordinate Ir(I) complexes generally is favored by a less σ-donating ligand trans to the vacant coordination site.   DFT calculation was used to investigate the oxidative addition of chlorobenzene and fluorobenzene to pincer iridium complexes.  Activation of the aryl C-H bonds proximal to the electron-withdrawing atom is favored.  The kinetic barriers were calculated and correlate with the relative steric interactions in the transition state leading to the oxidative addition product.  CO stretching frequencies for a series of Ni(CO)3L complexes were calculated using DFT calculations.  NBO analysis of these complexes yielded parameters that reflect the extent of backbonding in the π* orbitals of the CO ligands and polarization of the πb orbitals of the CO ligands.  The effects of a point charge on free CO were calculated.  Experimentally, reactions of small molecules with pincer iridium complexes were investigated.  The kinetic barriers for olefin dissociation from (pincer)Ir(olefin) complexes were measured.  The (tBuPOCOP)Ir-catalyzed olefin isomerization of 1-octene was investigated and shows an apparent 2nd order dependence on 1 octene concentration.   A synthesis scheme for tBu3MePCP ligand was developed.  While H2 did not add to tBu4PCPIr(CO), three isomers were observed when H2 was added to tBu3MePCPIr(CO), and the isomers were assigned using an isotopic labeling experiment and NMR spectroscopy.   The thermodynamic and kinetic products of tropone addition to (tBuPCP)IrH2 were synthesized and characterized.  The formation of a tropone dimer was investigated.  The product of methyl fluoride addition to (tBuPCP)IrH2 was characterized through NMR spectroscopy, LIFDI mass spectrometry, and elemental analysis.
Cantrainea peloritana
Creators: name: Ortega, José Rafael
name: Gofas, Serge
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Trochida
Colloniidae
Cantrainea
Cantrainea peloritana

description: Cantrainea peloritana (Cantraine, 1835)(Fig. 5A, B)
MATERIAL EXAMINED. — 1 sh., DW128; 1 spm and 2 sh. DW129.
REMARK
New record for the Canaries.
description: Published as part of Ortega, José Rafael & Gofas, Serge, 2019, The unknown bathyal of the Canaries: new species and new records of deep-sea Mollusca, pp. 513-551 in Zoosystema 41 (26) on page 522, DOI: 10.5252/zoosystema2019v41a26, http://zenodo.org/record/3726028
Troglopedetes dispersus Deharveng & Gers 1993
Creators: name: Jantarit, Sopark
name: Bedos, Anne
name: Deharveng, Louis
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Entognatha
Collembola
Paronellidae
Troglopedetes
Troglopedetes dispersus

description: 177. Troglopedetes dispersus Deharveng & Gers, 1993
Source: Deharveng & Gers (1993), Bedos (1994), Deharveng & Bedos (2001), Rojanavongse et al. (unpublished report). Type deposition: LEITT.
Distribution in Thailand. Kanchanaburi (W). Habitat: cave.
Distribution outside Thailand. Only known from Thailand.
description: Published as part of Jantarit, Sopark, Bedos, Anne & Deharveng, Louis, 2016, An annotated checklist of the Collembolan fauna of Thailand, pp. 301-360 in Zootaxa 4169 (2) on page 345, DOI: 10.11646/zootaxa.4169.2.4, http://zenodo.org/record/265801
GRM1, a potential target for human melanoma
Creators: name: Wall, Brian A.
Publisher: name: No Publisher Supplied
Year: 2013

description: The survival rate for patients with advanced metastasis ranges from 2 to 8 months with prolonged survival rates of 5% after 5 years. Targeted therapies have emerged as a paradigm for cancer treatments with the inhibition of multiple signaling pathways required to achieve greater successes in pre-clinical and clinical settings. Recent studies have demonstrated that disrupting the glutamatergic system yields promising therapeutic benefits in several cancers [1, 2, 3, 4]. The impediment of glutamate signaling in several of these cancer cell types activated apoptosis leading to decreased tumor cell proliferation and survival in vitro and in vivo. The amino acid, glutamate, is produced rapidly in tumor cells by the conversion of glutamine for use in protein and nucleotide synthesis, ATP production, and expulsion of excess carbon resulting from increased glucose metabolism (Warburg effect) in cancer cells. More recently, aberrant glutamate signaling has been shown to play a role in the transformation and maintenance of various cancer types, including melanoma. Glutamate secretion from these cells has been found to stimulate regulatory pathways that control tumor growth, proliferation and survival in vitro and in vivo. Our group showed that treatment of human melanoma with the glutamate release inhibitor, riluzole, caused a decrease in extracellular concentrations of glutamate in correlation with arrest at the G2/M phase of the cell cycle, followed by apoptotic cell death. Despite these observations, the precise mechanisms through which riluzole hampers melanoma cell survival remain to be elucidated. The present study begins to unravel the modes of action of riluzole in in vitro cultured melanoma cells. We identified a previously unknown consequence in cells treated with riluzole, DNA damage. Furthermore this observation was detected exclusively in melanoma cells expressing metabotropic glutamate receptor 1 (GRM1). Based on these two observations, we hypothesize that suppression of glutamate export from within the cells causes a disruption of intracellular homeostasis of glutamate/cystine exchange by the intracellular accumulation of unreleased glutamate. The limited amount of cystine results in a decrease of available glutathione (GSH) potentially increasing the levels of intracellular reactive oxygen species (ROS) followed by a rise in DNA damage.
On a 3GPP ray-based spatial channel model for MIMO system emulation
Creators: name: Vivek Sarathy, Sabarish Karthik
Publisher: name: No Publisher Supplied
Year: 2013

description: The mitigation of random effects in a wireless communication channel is a problem considered for many years. In the present day context, given the ever increasing need for, and growth of, bandwidth intensive applications like streaming wireless HD video on fast moving user equipment (UEs, i.e., user communication devices), this issue has intensified from being a theoretical pursuit to a must-be-solved practical endeavor. In that regard, the ability to accurately model the outdoor (or indoor) propagation conditions in a laboratory setting becomes vital to validating state-of-the-art wireless standards and the devices that derive from them. Laboratory-based analysis is a significant catalyst in reducing the time-to-market for telecom equipment manufacturers. Modeling a wireless channel has been a topic under quite a bit of study. This has progressed from the Jakes model developed for single antenna systems to the correlation and ray-based models used for multiple antenna systems. The models prescribed by the 3rd Generation Partnership Project (3GPP) in its standards, like the ray-based model, aim to realistically reproduce channel environments in software and hardware, by incorporating all the variables that characterize any particular fading scenario.   In this thesis, the technical report produced by 3GPP detailing the Spatial Channel Modeling (SCM) for multiple input multiple output (MIMO) simulations is followed closely as a basis for developing a real-time channel emulator on a National Instruments (NI) based Real Time (RT) Platform. First, a general purpose channel emulator is described in terms of its structure and functionality and currently known channel models are briefly investigated. Next, the spatial channel model in the standard is described in detail along with the reasons for choosing to use it in the thesis. All the parameters involved are defined, and the formula for constructing the channel is carefully investigated. Next, the channel emulator built on the National Instruments LabVIEW platform is described along with both the changes and modifications made to the design parameters so as to adapt it to the operating constraints of the RT platform. The spatial and temporal characteristics of the model are also described and plotted. Finally, the model is tested for reliability by methodically changing the various channel parameters and observing their effects on an Orthogonal Frequency Division Multiplexing (OFDM) test vector by generating BER performance plots in MATLAB. Diversity schemes are also employed to improve rate performance.
Genetic studies for selenate and tellurate reduction processes in facultative bacteria
Creators: name: Theisen, Joanne
Publisher: name: No Publisher Supplied
Year: 2013

description: The bioavailability and toxicity of selenium in the environment is strongly affected by redox transformations. In this study, we conducted spectroscopic, genetic, and macroscopic chemical measurements to investigate the ability of Citrobacter freundii to catalyze the reduction of soluble selenate oxyanions [Se(VI)] to poorly soluble elemental selenium [Se(0)]. The results indicate that C. freundii forms a red precipitate on selenate containing agar after 48 hours of incubation. In liquid culture, bulk chemical measurements show the removal of selenate oxyanions from solution only after oxygen is completely removed from the bacterial media. Selenate reduction by C. freundii is a substrate specific process and does not simply bind or absorb to cells, as it does not reduce arsenic under the same conditions.  X-ray absorption near edge spectra analysis of cell pellets collected from selenate incubations after 7 days show the formation of solid-phase elemental selenium. PCR amplification and DNA sequencing revealed that C. freundii carries the ynfEGH operon, a gene cluster in the DMSO reductase family previously shown to be responsible for selenate reduction in other gamma proteobacteria. Sequence analysis of ynfEGH operon possess a FNR binding site (Fumarate nitrate reduction regulator), and twin-arginine translocation (Tat) signal sequence, The environmental implications of selenate reduction by C. freundii for bioremediation purposes are discussed.   The genetic identity and co-factor composition of the bacterial tellurate reductase are currently unknown.  In this study, we examined the requirement of molybdopterin biosynthesis and molybdate transporter genes for tellurate reduction by Escherichia coli.  The results demonstrate that mutants carrying deletions of the moaA, moaB, moaE, or mog gene in molybdopterin biosynthesis pathway lost the ability to reduce tellurate.  Deletion of the modB or modC genes in molybdate transport pathway also resulted in complete loss of tellurate reduction activity. Genetic complementation by the wild-type sequences restored tellurate reduction activity in the mutant strains. These findings provide genetic evidence that the tellurate reductase in E. coli is a molybdopterin-containing enzyme.
Hydraulic properties of recycled wood material
Creators: name: Subroy, Vandana
Publisher: name: No Publisher Supplied
Year: 2013

description: Leachate from ground wood stockpiled at recycling facilities may be detrimental to water quality. Although mathematical modeling of water movement through stockpiles may help estimate leachate quantity, information on water retention and unsaturated hydraulic conductivity of wood particles needed to run the models are unavailable. Our objectives were to (a) estimate the hydraulic properties of field stockpiled wood material, (b) assess performance of three models of pore structure in simulating water flow, and (c) determine relationships between optimized hydraulic parameters and particle size.     The particle size distributions (PSDs) of thirty samples collected from stockpiles of coarsely and finely ground wood were measured, and their geometric mean diameters (dg) and distribution spreads (So) were used to establish two groups (I and II), with Group I samples having greater dg values for any given So than Group II samples. Six samples with PSDs representative of both groups were selected for hydraulic characterization. Material was packed in acrylic flow cells and outflow was induced by applying successive pressure potentials of -2, -10 and -40 cm to the bottom of the cells. Water retention data from outflow tests and from steady state measurements carried out in pressure extractors at potentials of -200, -500, -2000 and -10000 cm were fitted to unimodal and bimodal water retention functions. Inverse modeling of outflow data was performed using the software HYDRUS-1D and assuming (1) a unimodal pore-size distribution-SPM, (2) a bimodal pore-size distribution –DPM, (3) two distinct and interacting pore domains each with their own water retention and hydraulic conductivity functions-DPeM.    Wood material released almost 50% of their total water at -2 cm with Group I samples releasing significantly higher volumes than Group II. All models of pore structure captured outflow dynamics. Statistical tests indicated that the DPeM followed by the SPM were the best models for conductivity and the DPM for water retention. Parameters of hydraulic models could be estimated from PSD data. Predictions by all models indicate that hydraulic conductivity of the unsaturated material is very low (around 0.09 cm/hr at -10 cm), suggesting that water would move slowly through stockpiles except during intense rainfalls.
Cantrainea globuloides
Creators: name: Ortega, José Rafael
name: Gofas, Serge
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Trochida
Colloniidae
Cantrainea
Cantrainea globuloides

description: Cantrainea globuloides (Dautzenberg & H. Fischer, 1896)
(Fig. 5C, D)
MATERIAL EXAMINED. — 27 sh., DW130.
REMARK
The two European Cantrainea species were found in the transect, but not together in the same haul. New record for the Canaries.
description: Published as part of Ortega, José Rafael & Gofas, Serge, 2019, The unknown bathyal of the Canaries: new species and new records of deep-sea Mollusca, pp. 513-551 in Zoosystema 41 (26) on page 522, DOI: 10.5252/zoosystema2019v41a26, http://zenodo.org/record/3726028
Troglopedetes fredstonei Deharveng 1988
Creators: name: Jantarit, Sopark
name: Bedos, Anne
name: Deharveng, Louis
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Entognatha
Collembola
Paronellidae
Troglopedetes
Troglopedetes fredstonei

description: 178. Troglopedetes fredstonei Deharveng, 1988
Source: Deharveng (1988a), Bedos (1994), Deharveng & Bedos (2001). Type deposition: BPBM. Distribution in Thailand. Chiang Mai (N). Habitat: cave.
Distribution outside Thailand. Only known from Thailand.
description: Published as part of Jantarit, Sopark, Bedos, Anne & Deharveng, Louis, 2016, An annotated checklist of the Collembolan fauna of Thailand, pp. 301-360 in Zootaxa 4169 (2) on page 345, DOI: 10.11646/zootaxa.4169.2.4, http://zenodo.org/record/265801
The role of ephrin-A5 in lens maintenance and vitreous humor development
Creators: name: Son, Alexander I.
Publisher: name: No Publisher Supplied
Year: 2013

description: The development of the eye requires the orchestration of precise regulatory signals and events in constructing a complex structure capable of collecting visual inputs.  Recent observations have identified one group of molecules, the Eph family of receptor tyrosine kinases, to be critical in the formation of and maintenance of ocular tissues.  This present work focuses on the role of the Eph ligand ephrin-A5 in the development and function of the lens and vitreous humor.   We have found ephrin-A5 to be a major contributor to lens development and maintenance, as mice lacking ephrin-A5 develop cataracts.  Major lens abnormalities in the ephrin-A5-/- animals are observed at postnatal stages with lens opacity occurring by P21.  Examination of the expression of ephrin-A5 and its putative receptor EphA2 in the lens supports a fundamental role for this receptor-ligand complex in lens development.  As alterations in lens fiber cell shape were observed in the ephrin-A5-/- lens, we examined the role of ephrin-A5 and its receptor EphA2 on the control of the adherens junction.   N-cadherin localization is disrupted in the ephrin-A5-/- lens; however, β-catenin, a regulator of N-cadherin interaction with the actin cytoskeleton, remains on the membrane in the ephrin-A5-/- lens and co-localizes with EphA2.  Further examinations reveal Ephrin-A5 and EphA2 to regulate β-catenin interaction with N-cadherin, indicate that ephrin-A5 is required for maintaining proper lens fiber cell architecture through the regulation of the adherens junction.   We have also identified critical roles of ephrin-A5 in regression of the primary vitreous.  Failure of this event results in the eye disease Persistent Hyperplastic Primary Vitreous (PHPV).   Ephrin-A5-/- animals develop phenotypes representative of PHPV, most notably the presence a large hyperplastic mass posterior to the lens that remains throughout the lifetime of the animal.  The aberrant tissue consists of vascularized cells surrounded by pigmented cells of neural crest origin.  The mass in ephrin-A5-/- animals was also found to be mitotically active in both embryonic and postnatal stages signifying that ephrin-A5 has a role in cell cycle regulation in the developing vitreous.  Together, these studies demonstrate the critical and varied roles of ephrin-A5 throughout ocular development.
Introducing the Fundamental User Needs (FUN) Scales: Assessing Need Satisfaction and Frustration in Design-Mediated Interactions
Creators: name: Huang, Siyuan
name: Desmet, Pieter M. A.
name: Mugge, Ruth
Publisher: name: Taylor & Francis
Year: 2025
Subjects: Space Science
Medicine
Biotechnology
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Science Policy

description: This paper introduces the Fundamental User Needs (FUN) Scales, tailored to measure need satisfaction and frustration in design-mediated interactions. The development and initial validation process included a preparation phase and four studies. Adopting a deductive approach, we generated a pool of 780 items and distilled them into the first version of the FUN Scales: a 52-item Need Satisfaction Scale and a 52-item Need Frustration Scale. Content validity was assessed by nine experts, leading to a refined second version. Exploratory and confirmatory factor analyses with 502 participants examined the scales’ factorial structure, reliability, and validity, resulting in a finalized version with 39 items per scale. Finally, we proposed two scoring approaches to facilitate scale application. The FUN Scales can serve as a robust diagnostic tool for quantifying the psychological impact of design and technology through the lens of need fulfillment, offering structure and inspiration for human-centered design research and practice.
Ancistrobasis reticulata
Creators: name: Ortega, José Rafael
name: Gofas, Serge
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Seguenziida
Seguenziidae
Ancistrobasis
Ancistrobasis reticulata

description: Ancistrobasis reticulata (Philippi, 1844)
(Fig. 6)
Solarium reticulatum Philippi, 1844: 149; pl. 25, fig. 6.
Ancistrobasis lavaleyei Hoffman & Freiwald, 2017: 63, n. syn.
MATERIAL EXAMINED. — 24 sh., DW130,
REMARKS
New record for the Canaries. This species, originally described from Plio-Pleistocene strata in the valley of the Lamato river, in southernmost Calabria, Italy, has been reported in Recent NE Atlantic material by Warén & Bouchet (1990) from Galicia Bank, in 985- 100 m, and Warén (1991) from south of Iceland, in 970 m. It is actually quite well represented in our own material from Galicia Bank and from the Meteor and Atlantis seamounts, but the record here represents the southernmost known occurrence in the eastern Atlantic. The Western Atlantic A. costulata (Watson, 1879) described from off Culebra I., 390 fathoms, may be the same species but this has not been assessed.
Hoffman & Freiwald (2017) described Ancistrobasis lavaleyei based on a juvenile shell (1.43 × 1.89 mm) of A. reticulata collected on Coral Patch Seamount (34°58.00’N, 11°57.30’W, 1050 m) and included as a paratype an eroded shell from Galicia Bank. They mentioned that A. reticulata “is much larger, up to 10 mm; it has more than 10 spiral ribs that form a reticulated structure with nodes; and it lacks the angular outline on the first whorl.” Ancistrobasis reticulata does have an angular first whorl of teleoconch (Fig. 6C herein and Warén 1991: fig. 1A) and the number of spirals gradually increases from one on the first whorl to about ten on specimens approaching full size about 10 mm. Based on the Canarian specimens and on additional material collected by the SEAMOUNT 2 expedition on the Meteor group of seamounts, we cannot see any grounds for distinguishing more than one species of recent Ancistrobasis in the North Atlantic, and treat A. lavaleyei as a synonym of A. reticulata.
description: Published as part of Ortega, José Rafael & Gofas, Serge, 2019, The unknown bathyal of the Canaries: new species and new records of deep-sea Mollusca, pp. 513-551 in Zoosystema 41 (26) on page 522, DOI: 10.5252/zoosystema2019v41a26, http://zenodo.org/record/3726028
Troglopedetes leclerci Deharveng 1990
Creators: name: Jantarit, Sopark
name: Bedos, Anne
name: Deharveng, Louis
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Entognatha
Collembola
Paronellidae
Troglopedetes
Troglopedetes leclerci

description: 179. Troglopedetes leclerci Deharveng, 1990
Source: Deharveng (1990), Bedos (1994), Deharveng & Bedos (2001), Rojanavongse et al. (unpublished report). Type deposition: MNHN, BDCM, LEITT.
Distribution in Thailand. Chiang Mai (N). Habitat: cave.
Distribution outside Thailand. Only known from Thailand.
description: Published as part of Jantarit, Sopark, Bedos, Anne & Deharveng, Louis, 2016, An annotated checklist of the Collembolan fauna of Thailand, pp. 301-360 in Zootaxa 4169 (2) on page 345, DOI: 10.11646/zootaxa.4169.2.4, http://zenodo.org/record/265801
Suppression of mammary tumorigenesis by a Gemini vitamin D analog and a synthetic truterpenoid
Creators: name: So, Jae Young
Publisher: name: No Publisher Supplied
Year: 2013

description: Breast cancer is a heterogeneous disease categorized into multiple subtypes, including luminal, HER2-positive and basal-like subtypes, which exhibit distinct gene signatures and clinical outcomes. Basal-like breast cancer has the worst prognosis among these subtypes and has no clinically approved targeted therapy. While HER2-targeting therapy with a humanized HER2 monoclonal antibody markedly improved the prognosis of HER2-positive breast cancer, the de novo and acquired resistance against the antibody has emerged as a new challenge for patients with HER2-positive breast cancer.   MCF10 cell lines, a human breast cancer progression model representing the basal-like breast cancer subtype, were employed to identify key proteins involved in different stages of mammary tumorigenesis. Increased levels of IGF-IR, cyclin D1 and c-Myc were associated with HRAS-driven transformation. Higher levels of pErk, pAkt, STAT3 and Pak4 contribute to tumorigenicity in vivo, whereas CD44, HER2, COX-2 and Smad4 may be involved in the breast cancer progression.    The MCF10DCIS.com cells, one of the MCF10 cell lines, highly express a breast cancer stem cell marker, CD44. A Gemini vitamin D analog BXL0124 markedly repressed the CD44 protein level and the growth of MCF10DCIS.com xenograft tumors. CD44 overexpression was correlated with invasive phenotype in MCF10DCIS.com cells, and the repression of CD44 by BXL0124 contributed to the inhibition of cell invasion. STAT3, which interacts directly with CD44, was identified as a key downstream signaling molecule affected by BXL0124 in MCF10DCIS.com cells. The CD44 knockdown study supported the critical role of CD44-STAT3 signaling in the invasive potential of MCF10DCIS.com cells in vitro and in vivo.    The anti-cancer effects of BXL0124 and a synthetic triterpenoid CDDO-Im on HER2-positive breast cancer were tested in MMTV-HER2/neu transgenic mice. BXL0124, CDDO-Im and their combination delayed the development of mammary tumors and markedly inhibited the activation of HER2 and EGFR as well as their downstream molecules, such as Erk, Src and c-Myc in MMTV-HER2/neu mammary tumors.   In conclusion, we demonstrated  therapeutic potential of Gemini vitamin D analog BXL0124 targeting CD44-STAT3 signaling in basal-like breast cancer. In addition, we found anti-cancer activities of BXL0124 and CDDO-Im in HER2-positive breast cancer and potentially additive effects of their combination.
Troglopedetes longicornis Deharveng & Gers 1993
Creators: name: Jantarit, Sopark
name: Bedos, Anne
name: Deharveng, Louis
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Entognatha
Collembola
Paronellidae
Troglopedetes
Troglopedetes longicornis

description: 180. Troglopedetes longicornis Deharveng & Gers, 1993
Source: Deharveng & Gers (1993), Bedos (1994), Deharveng & Bedos (2001), Rojanavongse et al. (unpublished report). Type deposition: LEITT.
Distribution in Thailand. Mae Hong Son (N). Habitat: cave.
Distribution outside Thailand. Only known from Thailand
description: Published as part of Jantarit, Sopark, Bedos, Anne & Deharveng, Louis, 2016, An annotated checklist of the Collembolan fauna of Thailand, pp. 301-360 in Zootaxa 4169 (2) on page 345, DOI: 10.11646/zootaxa.4169.2.4, http://zenodo.org/record/265801
Chemopreventive activity of tocopherols in mammary tumorigenesis
Creators: name: Smolarek, Amanda Kathryn
Publisher: name: No Publisher Supplied
Year: 2013

description: Vitamin E is a dietary micronutrient that is recognized as a lipid-soluble antioxidant and suggested to reduce cancer risk. Tocopherol, a member of the vitamin E family, consists of four forms designated as alpha, beta, gamma, and delta. Several large cancer prevention studies with alpha-tocopherol have reported no beneficial results. Recent laboratory studies have suggested that γ-enriched mixed tocopherols (gamma-TmT), gamma-tocopherol and delta-tocopherol inhibit cancer by inhibiting cell proliferation and inducing apoptosis. The purpose of this thesis is to characterize the cancer preventive activities of gamma-TmT and individual (alpha-, delta-, gamma-) tocopherols in the prevention of two subtypes of breast cancer: estrogen receptor (ER) positive and human epidermal growth factor 2 (HER2) positive.    As a complex and heterogeneous disease, breast cancer is divided into subtypes such as ER positive, HER2 positive, or basal-like. Animal models are utilized to define etiology of breast cancer and generate new prevention and treatment strategies.   In three different animal models of breast cancer, the chemopreventive activities of gamma-TmT or individual tocopherols (alpha, delta or gamma) were assessed. Due to their sensitivity to 17beta-estradiol (E2) to induce mammary hyperplasia, female August Copenhagen Irish (ACI) rats were utilized. Immunohistochemical analysis of the mammary glands revealed a decrease in estrogen receptor alpha (ERalpha) and proliferating cell nuclear antigen (PCNA), while there was an increase in cleaved-caspase 3, peroxisome proliferator activated receptor gamma (PPARgamma), and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in gamma-TmT treated rats.   In a second animal model, individual delta- and gamma-tocopherols inhibited hormone-dependent mammary tumorigenesis in N-methyl-N-nitrosourea (NMU)-treated female Sprague Dawley rats, whereas alpha-tocopherol did not decrease tumor burden. In mammary tumors, markers of cell proliferation (PCNA, PKCalpha), survival (PPARgamma, PTEN, phospho-Akt) and cell cycle (p53, p21) were affected by delta- and gamma-tocopherols.   However, in the third animal model, administration of individual tocopherols did not prevent HER2/neu-driven tumorigenesis. There were modest effects by gamma-tocopherols on increased tumor latency, but the overall tumor burden was not significantly decreased.   In conclusion, delta-tocopherol, gamma-tocopherol and gamma-TmT, but not alpha-tocopherol, have exhibited chemopreventive properties in two estrogen-dependent animal models, but not in transgenic HER2-driven breast cancer.
Toroidia toroides
Creators: name: Ortega, José Rafael
name: Gofas, Serge
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Seguenziida
Eucyclidae
Toroidia
Toroidia toroides

description: Toroidia toroides (Hoffman, van Heugten & Lavaleye, 2011)
(Fig. 7A)
MATERIAL EXAMINED. — 18 sh., DW130.
REMARKS
This is the first report of this species after its original description from off NW Morocco in 529 m. It was diagnosed by the occurrence of a spiral sculpture whereas the interspaces between ribs are smooth in the similar Margarites laminarum (Jeffreys, 1883), described from off Portugal and reported from Ampère Seamount (Beck et al. 2006). The original generic placement in Margarites was not tenable, and the new genus Toroidia was established by Hoffman & Freiwald (2018), but the family placement is tentative in the absence of data on the soft parts. New to Spanish waters.
description: Published as part of Ortega, José Rafael & Gofas, Serge, 2019, The unknown bathyal of the Canaries: new species and new records of deep-sea Mollusca, pp. 513-551 in Zoosystema 41 (26) on page 523, DOI: 10.5252/zoosystema2019v41a26, http://zenodo.org/record/3726028
Cross-ethnic measurement invariance of the SCARED and CES-D in an ethnically diverse youth sample
Creators: name: Skriner, Laura C.
Publisher: name: No Publisher Supplied
Year: 2013

description: This study evaluated the cross-ethnic measurement invariance of two common screening measures of anxiety and depressive symptoms in youth. The measurement invariance of the Screen for Childhood Anxiety and Related Emotional Disorders (SCARED) and the Center for Epidemiologic Studies Depression Scale (CES-D) was tested across 881 African American (n = 396), Latino (n = 185), Non-Hispanic White (n = 166), and Asian/Indian (n = 134) youths in the seventh grade. The measures were administered as part of a grade-wide screening aimed to identify youth with elevated anxiety and depressive symptoms. The five-factor model of the SCARED and the four-factor model of the CESD best represented the data for all ethnic groups. Results provided support for scalar equivalence of the SCARED across all four ethnic groups. Results provided support for scalar equivalence of the CES-D across African American (AA), Non-Hispanic White (NHW), and Asian/Indian youths, and partial invariance for Hispanic youths. Factor mean differences across groups were identified for both measures. In particular, Hispanic youth reported greater levels of anxiety and depression in certain domains than NHW, AA, and Asian youth. Our findings support the use of the SCARED and CESD as tools for measuring anxiety and depressive symptoms in ethnically diverse youth in the U.S. Results are discussed with respect to the importance of establishing measurement invariance for screening measures of anxiety and depressive symptoms prior to comparing symptom levels across ethnic.
Troglopedetes maffrei Deharveng & Gers 1993
Creators: name: Jantarit, Sopark
name: Bedos, Anne
name: Deharveng, Louis
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Entognatha
Collembola
Paronellidae
Troglopedetes
Troglopedetes maffrei

description: 181. Troglopedetes maffrei Deharveng & Gers, 1993
Source: Deharveng & Gers (1993), Bedos (1994), Deharveng & Bedos (2001), Rojanavongse et al. (unpublished report). Type deposition: LEITT.
Distribution in Thailand. Mae Hong Son (N). Habitat: cave.
Distribution outside Thailand. Only known from Thailand.
description: Published as part of Jantarit, Sopark, Bedos, Anne & Deharveng, Louis, 2016, An annotated checklist of the Collembolan fauna of Thailand, pp. 301-360 in Zootaxa 4169 (2) on page 345, DOI: 10.11646/zootaxa.4169.2.4, http://zenodo.org/record/265801
Targeted nanomedicine platform for cancer stem cells specific therapy
Creators: name: Shah, Vatsal V.
Publisher: name: No Publisher Supplied
Year: 2013

description: Cancer is one of the most fatal diseases in the world. More than 10 million cases of cancer are reported every year.  It is responsible for one in 4 deaths in the United States.The agents that are currently used for chemotherapy fail to differentiate between the cancerous and normal cells leading to numerous adverse side-effects. Owing to their toxicity, there is limitation to the amount of dose that can be administered. Due to the lack of specificity and restriction of dose, it sometimes becomes very difficult to achieve an effective concentration within the cancer affected tissues .    One of the purposes of this proposal is to evaluate various drug delivery systems utilized in cancer therapy or diagnosis for genotoxicity. If a drug delivery system is found to be genotoxic, we propose to modify these genotoxic systems so as to reduce or completely eliminate their genotoxicity. We also propose to test certain raw materials used in cosmetic industry on a regular bases for genotoxicity. The other purpose of this study is to develop a dendrimer based drug delivery system that would specifically knock down CD44 in cancerous cells. Once CD44 is knocked down, we plan to treat the cancer cells specifically using a chemotherapeutic drug, Paclitaxel attached to PPi dendrimer.
Exploring the function of TRF-1, a tumor necrosis factor (TNF) receptor associated factor (TRAF) in C. elegans polycystin-expressing sensory neurons
Creators: name: Santiago-Martinez, Dianaliz
Publisher: name: No Publisher Supplied
Year: 2013

description: TRAFs are adaptor molecules that function mainly in the immune system.  Mammals have seven TRAFs that share a conserved C-terminal domain. The C. elegans genome encodes two TRAF genes, trf-1 and trf-2 (Y110A7A.2). In humans, mutations in the polycystin-1 (PC-1) or polycystin-2 (PC-2) ciliary mechanosensory complex cause ADPKD. In C. elegans, the polycystins LOV-1 and PKD-2 localize to cilia and are required for male sensory behaviors.   We find that trf-1 is co-expressed with pkd-2 in the male specific CEM, RnB, and HOB neurons and is required for male mating behaviors. We are interested in exploring a potential connection between immune recognition and mate recognition.  We examined the mating behavior of mutant males defective in the Toll pathway including tol-1 and ikb-1. We performed leaving, retention, response, and vulva location (Lov) behavior assays. Like pkd-2 mutants, trf-1(nr2014) mutant males have response and Lov defects. In contrast, tol-1 and ikb-1 are like the wild-type. trf-1 and pkd-2 males are leaving assay (Las) defective, whereas tol-1 is Las but statistically different from pkd-2 and trf-1.   ikb-1 males are not Las.  All mutant strains are normal for the retention assay, indicating that these males can sense the presence of a mate. We conclude that trf-1 acts like pkd-2, suggesting they function in a similar pathway. The other TRAF gene, trf-2, is also mating defective and seems to act in the same pathway as trf-1.  trf-1 and trf-2 act non-redundantly, since the double mutant does not yield a stronger phenotype.    To ascertain the site of TRF-1 action, we generated transgenic animals expressing TRF-1::GFP. TRF-1::GFP localizes to cell bodies, dendrites and axons of CEM, HOB and RnB neurons.  TRF-1::GFP is detectable in sensory cilia. The mating defects were partially rescued in the mutant.    Genetic interactions between TRF-1 and components of the C. elegans PKD pathway (LOV-1, PKD-2, and KLP-6) showed no interaction in yeast two-hybrid experiments.  Interestingly, TRF-1 showed interaction with EBAX-1/PQN-55, a substrate recognition subunit for cullin based E3 ligase complex.  Ebax-1/pqn-55 males were also shown to be response and location of vulva defective.  pqn-55 may act in the PKD pathway as well.
Rugulina Palazzi 1988
Creators: name: Ortega, José Rafael
name: Gofas, Serge
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Seguenziida
Pendromidae
Rugulina

description: Genus Rugulina Palazzi, 1988
TYPE SPECIES. — Daronia monterosatoi van Aartsen & Bogi, 1986, by original designation.
description: Published as part of Ortega, José Rafael & Gofas, Serge, 2019, The unknown bathyal of the Canaries: new species and new records of deep-sea Mollusca, pp. 513-551 in Zoosystema 41 (26) on page 523, DOI: 10.5252/zoosystema2019v41a26, http://zenodo.org/record/3726028
Troglopedetes maungonensis Deharveng & Gers 1993
Creators: name: Jantarit, Sopark
name: Bedos, Anne
name: Deharveng, Louis
Publisher: name: Zenodo
Year: 2016
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Entognatha
Collembola
Paronellidae
Troglopedetes
Troglopedetes maungonensis

description: 182. Troglopedetes maungonensis Deharveng & Gers, 1993
Source: Deharveng & Gers (1993), Bedos (1994), Deharveng & Bedos (2001), Rojanavongse et al. (unpublished report). Type deposition: LEITT.
Distribution in Thailand. Chiang Mai (N). Habitat: cave.
Distribution outside Thailand. Only known from Thailand.
description: Published as part of Jantarit, Sopark, Bedos, Anne & Deharveng, Louis, 2016, An annotated checklist of the Collembolan fauna of Thailand, pp. 301-360 in Zootaxa 4169 (2) on page 345, DOI: 10.11646/zootaxa.4169.2.4, http://zenodo.org/record/265801
The Impact of Capillary Heterogeneity on CO2 plume migration at the Endurance CO2 storage Site in the UK
Creators: name: Wenck, Nele
name: Muggeridge, Ann
name: Jackson, Samuel
name: An, Senyou
name: Krevor, Sam
Publisher: name: Geological Society of London
Year: 2025
Subjects: classificationCode: 3705
subject: Geology
subject: FOS: Earth and related environmental sciences

description: Supplementary material describing the approach and verification of the Upscaling Workflow
The source of toxicity in CTAB and CTAB-stabilized gold nanorods
Creators: name: Schachter, David
Publisher: name: No Publisher Supplied
Year: 2013

description: The use of nanoparticles for sensing, cell imaging, and therapy has seen an extraordinary increase, in recent years. But, one of the issues commonly encountered when using nanoparticles in bioapplications is their toxicity.   Cetyltrimethylammonium bromide (CTAB) is a common surfactant used in nanoparticle synthesis. One of CTAB’s uses is to direct the growth and stabilize the shape of certain types of colloidal metallic nanoparticles, for example gold nanorods. The main drawback is that these metallic nanoparticles cannot be used in applications with cells because of their cytotoxicity. Despite many conjectures, it is not yet clear what the origin of this cytotoxicity is. Here we explore some possible reasons and mechanisms that could be accounted for to explain this cytotoxicity.   Due to its molecular structure, CTAB is difficult to detect in solution using conventional methods. In this thesis work, electrospray ionization mass spectrometry (ESI-MS) was used as a means to detect CTAB in solution and in vitro and to study the source of its toxicity. From the data collected, we have evidence that there are two active mechanisms: 1) CTAB’s interaction with the phospholipid bilayer that destabilizes the cell membrane leading to cell death, and 2) the catalytic action of one of CTAB’s dissociation products, the CTA+ cation, which might cause the quenching of the enzyme ATPsynthase and thus lead to energy deprivation and death of the cell. Our results also indicate that it is this second mechanism, which depends on the concentration of CTA+, to be the most lethal.  We have found that nanorods can be successfully formed with high concentrations of Br-, which is non-toxic, with limited amounts of CTAB, because CTA+ might be playing a more important role only for stability purposes. This will reduce the amount of CTAB in solution to below cytotoxic values. We have also found out that once the nanorods are formed using CTAB as the stabilizing surfactant, low concentrations of an iodine/iodide mixture are able to modify, post-fabrication, the aspect ratio of the nanorods and thus their optical properties. This discovery might lead to the development of a new category of gold nanorods, with decreased toxicity and tunable morphology that would be ideal for applications in conjunction to cells.