cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Couponing's Growth in Food Marketing
Creators: name: Gallo, Anthony E.
name: Hamm, Larry G.
name: Zellner, James A.
name: Gallo, Anthony E.
name: Hamm, Larry G.
name: Zellner, James A.
Publisher: name: Unknown
Year: 1982
Subjects: subject: Food Consumption/Nutrition/Food Safety
subject: Marketing
subject: FOS: Economics and business
subject: Food
subject: retailing
subject: coupons
subject: coupon redemption
subject: double couponing

description: The number of cents-off coupons distributed by manufacturers and retailers rose from 10 billion to 90 billion between 1965 and 1980. About 80 percent of U.S. households redeemed coupons in 1979, making coupons the most rapidly growing form of food advertising. Although coupons still make up the smallest portion of all major food advertising, their value rose from less than 6 percent of total advertising expenditures in 1970 to 11 percent in 1979. This report analyzes the use of coupons by consumers, as a marketing tool by manufacturers and retailers, and in the marketing of farm produce.
title: MR imaging in parkinsonism, an algorithmic approach
Creators: name: Herrera Parra, Nicolas
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Neuroradiology brain
subject: MR
subject: Decision analysis
subject: Developmental disease

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Explain the spectrum of MRI findings in Parkinson's disease and parkinsonian syndrome-related disorders, clarify the role of MRI in the differential diagnosis and summarize the relevant findings in an algorithmic...
(401640) Jane Liddle Aitken
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Higgs production in bottom-quark fusion in a matched scheme
Creators: name: Forte, Stefano
name: Napoletano, Davide
name: Ubiali, Maria
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We compute the total cross-section for Higgs boson production in bottom-quark fusion using the so-called FONLL method for the matching of a scheme in which the $b$-quark is treated as a massless parton to that in which it is treated as a massive final-state particle. We discuss the general framework for the application of the FONLL method to this process, and then we present explicit expressions for the case in which the next-to-next-to-leading-log five-flavor scheme result is combined with the leading-order $\cal O(α_s^2)$ four-flavor scheme computation. We compare our results in this case to the four-and five-flavor scheme computations, and to the so-called Santander matching.
description: 15 pages, 4 figures; three typos corrected. Final version, to be published in Phys. Lett. B
Nuclear and Spindle Dynamics in Budding Yeast
Creators: name: Shaw, Sidney L.
name: Maddox, Paul
name: Yeh, Elaine
name: Bloom, Kerry
name: Skibbens, Robert V.
name: Salmon, E. D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: The wealth of information from genetic and more recently genomic studies of the budding yeast has been staggering. However, the small size of the organism has limited traditional cytological approaches. Thus there is a disparity in our detailed understanding of the genetic control of mitosis, for instance, relative to the morphology of mitosis. The application of time-lapse high-resolution digital-enhanced differential interference contrast (DE-DIC) and multimode fluoresence microscopy to studying yeast cell division has revealed a very dynamic process that reflects the interplay among microtubule dynamics, microtubule-based motor proteins, and positional determinants in the mother and bud (Salmon et al., 1998a ,b ; Shaw et al., 1997a ,b ).
title: Lynch Syndrome, abdominal manifestations and crucial contribution of genitourinary tract malignancies
Creators: name: Durany Lara, David
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Gastrointestinal tract
subject: Genital / Reproductive system female
subject: Urinary Tract / Bladder
subject: CT
subject: MR
subject: PET-CT
subject: Molecular imaging
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Our main purpose is to show the most important genitourinary manifestations in Lynch syndrome (LS) as extra-colonic malignancies and to determine the relevance of genitourinary involvement in the general manifestations of the...
MODELLING SUPERFLUID NEUTRON STARS APPLICATIONS TO PULSAR GLITCHES
Creators: name: ANTONELLI, MARCO
Publisher: name: Universit� degli Studi di Milano
Year: 2018

description: In this dissertation I discuss how observations of the maximum glitch occurred in a certain pulsar provides a test for the microscopic physics of neutron star interiors, in particular the pinning forces (a parameter which effectively describes the strength of the vortex-lattice interaction at the mesoscopic scale). Conversely, by fixing the input parameters by taking estimates from recent literature, it is possible to estimate the mass of a glitching pulsar. A proof of concept of this thesis is given by constructing a quantitative model for pulsar rotational dynamics that can consistently encode state of the art models of the pinning force between vortices and ions in the crust, as well as the stratified structure of a neutron star. This point is far from being secondary as most studies on pulsar glitches are based on body-averaged models or differential models that tacitly assume a cylindrical symmetry, not consistent with the spherically layered structure.
title: PERIPANCREATIC PSEUDOANEURYSMS – Review on a rare but potentially lethal complication of pancreatitis
Creators: name: Baicoianu-Nitescu, Alexandru-Stefan
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Interventional vascular
subject: Pancreas
subject: Catheter arteriography
subject: CT
subject: Diagnostic procedure
subject: Embolisation
subject: Acute

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To discuss the most frequently used imaging modalities in diagnosing peripancreatic pseudoaneurysms. To identify the most eloquent imaging features that highlight this life-threatening diagnosis. To determine the main pathologies included in the...
Does snake envenoming cause chronic kidney disease? A cohort study in rural Sri Lanka
Creators: name: Waiddyanatha, Subodha
name: Silva, Anjana
name: Weerakoon, Kosala
name: Siribaddana, Sisira
name: Isbister, Geoffrey K.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Marine Biology
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences
subject: Computational Biology

description: There is limited information on the risk of chronic kidney disease (CKD) following snakebite and its relationship with chronic interstitial nephritis in agricultural communities (CINAC). We aimed to investigate CKD in patients with a confirmed snakebite in rural Sri Lanka. Patients prospectively recruited to the Anuradhapura snakebite cohort with authenticated bites were followed up. Two groups of patients were followed up: 199 patients in group I with a snakebite (August 2013–October 2014), reviewed after 4 years, and 168 patients in group II with a snakebite (May 2017–August 2018), reviewed after one year, with serum creatinine (estimated glomerular filtration rate [eGFR]) and urinary albumin to creatinine ratio (ACR). There were 12/199 (6%) in group I and 9/168 (5%) in group II with AKI following snakebite; 3/12 in group I and 2/9 in group II had haemodialysis. On review after 1 and 4 years, no patient had CKD and all had an eGFR ≥60 mL/min/1.73m2. Of 234 patients with a creatinine measured on discharge, 17/140 in group I and 11/94 in group II had a low eGFR (<60mL/min/1.73m2). In group I, 14/17 had a normal eGFR after four years, including 11/12 who had AKI following snakebite, and the 3/17 with a low eGFR on review had CKD or co-morbidities for CKD. In group II, 10/11 had a normal eGFR after one year, including all nine patients with AKI following snakebite, and the one patient with a low eGFR on review had CKD. Fifty patients (25%) in group I and 43 (26%) in group II had a high urinary ACR on review, all but two in each group had microalbuminuria. Multivariate logistic regression showed in group I that only comorbidities for CKD were associated with high urinary ACR, and in group II comorbidities for CKD, snakebite associated AKI and snake type were associated with high urinary ACR. All nine patients from both groups with a low eGFR (CKD stages 3–5) had CKD prior to the snakebite or treatment for hypertension or diabetes. There was no significant association between snakebite-associated AKI and CKD in patients followed up from a snakebite cohort post-bite. Microalbuminuria was common in these patients but likely associated with hypertension, diabetes mellitus and CINAC in this rural farming population.
title: Dual-energy (spectral) computed tomography as a problem-solving tool in renal imaging – experience from a single centre.
Creators: name: Moreland, Michelle
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Abdomen
subject: Kidney
subject: CT
subject: Computer Applications-Detection, diagnosis
subject: Calcifications / Calculi
subject: Neoplasia

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Dual-energy (spectral) computed tomography (CT) is being increasingly used in renal imaging due to its improved accuracy in the identification, characterisation, and differentiation of material densities. A selection of interesting adult cases...
A perturbation-based susbtep method for coupled depletion Monte-Carlo codes
Creators: name: Shwageraus, Evgeni
name: Kotlyar, D
name: Aufiero, M
name: Fratoni, M
Publisher: name: Apollo - University of Cambridge Repository
Year: 2017
Subjects: Monte Carlo
coupled codes
depletion
general perturbation theory
Serpent

description: Coupled Monte Carlo (MC) methods are becoming widely used in reactor physics analysis and design. Many research groups therefore, developed their own coupled MC depletion codes. Typically, in such coupled code systems, neutron fluxes and cross sections are provided to the depletion module by solving a static neutron transport problem. These fluxes and cross sections are representative only of a specific time-point. In reality however, both quantities would change through the depletion time interval. Recently, Generalized Perturbation Theory (GPT) equivalent method that relies on collision history approach was implemented in Serpent MC code. This method was used here to calculate the sensitivity of each nuclide and reaction cross section due to the change in concentration of every isotope in the system. The coupling method proposed in this study also uses the substep approach, which incorporates these sensitivity coefficients to account for temporal changes in cross sections. As a result, a notable improvement in time dependent cross section behavior was obtained. The method was implemented in a wrapper script that couples Serpent with an external depletion solver. The performance of this method was compared with other existing methods. The results indicate that the proposed method requires substantially less MC transport solutions to achieve the same accuracy.
Putting a Stop to di-Higgs Modifications
Creators: name: Batell, Brian
name: McCullough, Matthew
name: Stolarski, Daniel
name: Verhaaren, Christopher B.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Pair production of Higgs bosons at hadron colliders is an enticing channel to search for new physics. New colored particles that couple strongly to the Higgs, such as those most often called upon to address the hierarchy problem, provide well motivated examples in which large enhancements of the di-Higgs rate are possible, at least in principle. However, in such scenarios the di-Higgs production rate is tightly correlated with the single Higgs production rate and, since the latter is observed to be SM-like, one generally expects that only modest enhancements in di-Higgs production are allowed by the LHC Run 1 data. We examine the contribution of top squarks (stops) in a simplified supersymmetry model to di-Higgs production and find that this general expectation is indeed borne out. In particular, the allowed deviations are typically small, but there are tuned regions of parameter space where expectations based on EFT arguments break down in which order 100% enhancements to the di-Higgs production rate are possible and are simultaneously consistent with the observed single Higgs production rates. These effects are potentially observable with the high luminosity run of the LHC or at a future hadron collider.
description: 16 pages + refrences; v2 updated references; v3 Published version
Coiled Bodies Preferentially Associate with U4, U11, and U12 Small Nuclear RNA Genes in Interphase HeLa Cells but Not with U6 and U7 Genes
Creators: name: Gebuhr, Thomas C.
name: Ingledue, Thomas C.
name: Frey, Mark R.
name: Marzluff, William F.
name: Matera, A. Gregory
name: Wu, Wei
name: Gao, Liming
name: Jacobs, Erica Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: Coiled bodies (CBs) are nuclear organelles involved in the metabolism of small nuclear RNAs (snRNAs) and histone messages. Their structural morphology and molecular composition have been conserved from plants to animals. CBs preferentially and specifically associate with genes that encode U1, U2, and U3 snRNAs as well as the cell cycle–regulated histone loci. A common link among these previously identified CB-associated genes is that they are either clustered or tandemly repeated in the human genome. In an effort to identify additional loci that associate with CBs, we have isolated and mapped the chromosomal locations of genomic clones corresponding to bona fide U4, U6, U7, U11, and U12 snRNA loci. Unlike the clustered U1 and U2 genes, each of these loci encode a single gene, with the exception of the U4 clone, which contains two genes. We next examined the association of these snRNA genes with CBs and found that they colocalized less frequently than their multicopy counterparts. To differentiate a lower level of preferential association from random colocalization, we developed a theoretical model of random colocalization, which yielded expected values for χ2 tests against the experimental data. Certain single-copy snRNA genes (U4, U11, and U12) but not controls were found to significantly (p < 0.000001) associate with CBs. Recent evidence indicates that the interactions between CBs and genes are mediated by nascent transcripts. Taken together, these new results suggest that CB association may be substantially augmented by the increased transcriptional capacity of clustered genes. Possible functional roles for the observed interactions of CBs with snRNA genes are discussed.
Complex Formation with Focal Adhesion Kinase: A Mechanism to Regulate Activity and Subcellular Localization of Src Kinases
Creators: name: Schaller, Michael D.
name: Hildebrand, Jeffrey D.
name: Parsons, J. Thomas
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: Tyrosine phosphorylation of focal adhesion kinase (FAK) creates a high-affinity binding site for the src homology 2 domain of the Src family of tyrosine kinases. Assembly of a complex between FAK and Src kinases may serve to regulate the subcellular localization and the enzymatic activity of members of the Src family of kinases. We show that simultaneous overexpression of FAK and pp60c-src or p59fyn results in the enhancement of the tyrosine phosphorylation of a limited number of cellular substrates, including paxillin. Under these conditions, tyrosine phosphorylation of paxillin is largely cell adhesion dependent. FAK mutants defective for Src binding or focal adhesion targeting fail to cooperate with pp60c-src or p59fyn to induce paxillin phosphorylation, whereas catalytically defective FAK mutants can direct paxillin phosphorylation. The negative regulatory site of pp60c-src is hypophosphorylated when in complex with FAK, and coexpression with FAK leads to a redistribution of pp60c-src from a diffuse cellular location to focal adhesions. A FAK mutant defective for Src binding does not effectively induce the translocation of pp60c-src to focal adhesions. These results suggest that association with FAK can alter the localization of Src kinases and that FAK functions to direct phosphorylation of cellular substrates by recruitment of Src kinases.
title: Contrast-enhanced Ultrasound (CEUS) in children: a world to discover
Creators: name: Basso, Luca
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Contrast agents
subject: Emergency
subject: Paediatric
subject: CT
subject: MR
subject: Ultrasound
subject: Contrast agent-intravenous
subject: Education
subject: Technical aspects
subject: Artifacts
subject: Inflammation
subject: Trauma

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: To describe indications and limits of Contrast-enhanced Ultrasound (CEUS) in pediatric radiology, also discussing its potential and future possible...
(401636) Samuel Millar Low
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
IceCube neutrinos, decaying dark matter, and the Hubble constant
Creators: name: Anchordoqui, Luis A.
name: Barger, Vernon
name: Goldberg, Haim
name: Huang, Xing
name: Marfatia, Danny
name: da Silva, Luiz H. M.
name: Weiler, Thomas J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Cosmological parameters deduced from the Planck measurements of anisotropies in the cosmic microwave background are at some tension with direct astronomical measurements of various parameters at low redshifts. Very recently, it has been conjectured that this discrepancy can be reconciled if a certain fraction of dark matter is unstable and decays between recombination and the present epoch. Herein we show that if the superheavy relics have a branching into neutrinos B (X \to ν\bar ν) \sim 3 \times 10^{-9}, then this scenario can also accommodate the recently discovered extraterrestrial flux of neutrinos, relaxing the tension between IceCube results and Fermi LAT data. The model is fully predictive and can be confronted with future IceCube data. We demonstrate that in 10 years of observation IceCube will be able to distinguish the mono-energetic signal from X decay at the 3σlevel. In a few years of data taking with the upgraded IceCube-Gen2 enough statistics will be gathered to elucidate the dark matter--neutrino connection at the 5σlevel.
description: In version 2 of arXiv:1505.03644, the required dark matter decay width is reduced by two orders of magnitude. We update our analysis accordingly and account for the new analysis of arXiv:1602.08121 that incorporates lensing constraints
Focal Adhesion Targeting: The Critical Determinant of FAK Regulation and Substrate Phosphorylation
Creators: name: Shen, Yu
name: Schaller, Michael D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: The focal adhesion kinase (FAK) is discretely localized to focal adhesions via its C-terminal focal adhesion–targeting (FAT) sequence. FAK is regulated by integrin-dependent cell adhesion and can regulate tyrosine phosphorylation of downstream substrates, like paxillin. By the use of a mutational strategy, the regions of FAK that are required for cell adhesion–dependent regulation and for inducing tyrosine phosphorylation of paxillin were determined. The results show that the FAT sequence was the single region of FAK that was required for each function. Furthermore, the FAT sequence of FAK was replaced with a focal adhesion–targeting sequence from vinculin, and the resulting chimera exhibited cell adhesion–dependent tyrosine phosphorylation and could induce paxillin phosphorylation like wild-type FAK. These results suggest that subcellular localization is the major determinant of FAK function.
title: Upper Urinary Tract Infections in Adults: The Value of CT Scanning
Creators: name: EL MAHFOUDI, SALWA
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Kidney
subject: CT
subject: Complications
subject: Diagnostic procedure
subject: eLearning
subject: Infection

description: Purpose Methods and materials Results Conclusion Personal information and conflict of interest References
description: Purpose: Most infections of the upper urinary tract are uncomplicated, and its diagnosis rests only on clinical criteria (fever, functional urinary signs, lumbar fossa pain...) and laboratoryresults. They don't need any emergency radiological...
(401637) Peter Carmichael
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Modeling Galactic Conformity with the Color-Halo Age Relation in the Illustris Simulation
Creators: name: Bray, Aaron D.
name: Pillepich, Annalisa
name: Sales, Laura V.
name: Zhu, Emily
name: Genel, Shy
name: Rodriguez-Gomez, Vicente
name: Torrey, Paul
name: Nelson, Dylan
name: Vogelsberger, Mark
name: Springel, Volker
name: Eisenstein, Daniel J.
name: Hernquist, Lars
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Comparisons between observational surveys and galaxy formation models find that the mass of dark matter haloes can largely explain galaxies' stellar mass. However, it remains uncertain whether additional environmental variables, generally referred to as assembly bias, are necessary to explain other galaxy properties. We use the Illustris Simulation to investigate the role of assembly bias in producing galactic conformity by considering 18,000 galaxies with $M_{stellar}$ > $2 \times 10^9$ $M_{\odot}$. We find a significant signal of galactic conformity: out to distances of about 10 Mpc, the mean red fraction of galaxies around redder galaxies is higher than around bluer galaxies at fixed stellar mass. Dark matter haloes exhibit an analogous conformity signal, in which the fraction of haloes formed at earlier times (old haloes) is higher around old haloes than around younger ones at fixed halo mass. A plausible interpretation of galactic conformity can be given as a combination of the halo conformity signal with the galaxy color-halo age relation: at fixed stellar mass, particularly toward the low-mass end, Illustris' galaxy colors correlate with halo age, with the reddest galaxies (often satellites) being preferentially found in the oldest haloes. In fact, we can explain the galactic conformity effect with a simple semi-empirical model, by assigning stellar mass based on halo mass (abundance matching) and by assigning galaxy color based on halo age (age matching). We investigate other interpretations for the galactic conformity, particularly its dependence on the isolation criterion and on the central-satellite information. Regarding comparison to observations, we conclude that the adopted selection/isolation criteria, projection effects, and stacking techniques can have a significant impact on the measured amplitude of the conformity signal.
description: 15 pages, 8 figures; accepted for publication in MNRAS (minor revisions to match accepted version)
The Stem-Loop Binding Protein (SLBP1) Is Present in Coiled Bodies of the Xenopus Germinal Vesicle
Creators: name: Gall, Joseph G.
name: Abbott, Jennifer
name: Marzluff, William F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: The stem-loop binding protein (SLBP1) binds the 3′ stem-loop of histone pre-mRNA and is required for efficient processing of histone transcripts in the nucleus. We examined the localization of SLBP1 in the germinal vesicle of Xenopus laevis oocytes. In spread preparations of germinal vesicle contents, an anti-SLBP1 antibody stained coiled bodies and specific chromosomal loci, including terminal granules, axial granules, and some loops. After injection of myc-tagged SLBP1 transcripts into the oocyte cytoplasm, newly translated myc-SLBP1 protein was detectable in coiled bodies within 4 h and in terminal and axial granules by 8 h. To identify the region(s) of SLBP1 necessary for subnuclear localization, we subcloned various parts of the SLBP1 cDNA and injected transcripts of these into the cytoplasm of oocytes. We determined that 113 amino acids at the carboxy terminus of SLBP1 are sufficient for coiled body localization and that disruption of a previously defined RNA-binding domain did not alter this localization. Coiled bodies also contain the U7 small nuclear ribonucleoprotein particle (snRNP), which participates in cleavage of the 3′ end of histone pre-mRNA. The colocalization of SLBP1 and the U7 snRNP in the coiled body suggests coordinated control of their functions, perhaps through a larger histone-processing particle. Some coiled bodies are attached to the lampbrush chromosomes at the histone gene loci, consistent with the view that coiled bodies in the oocyte recruit histone-processing factors to the sites of histone pre-mRNA transcription. The non-histone chromosomal sites at which SLBP1 is found include the genes coding for 5 S rRNA, U1 snRNA, and U2 snRNA, suggesting a wider role for SLBP1 in the biosynthesis of small non-spliced RNAs.
(401632) James Boyd
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Dynamic Positioning of Mitotic Spindles in Yeast:: Role of Microtubule Motors and Cortical Determinants
Creators: name: Bloom, K.
name: Chin, E.
name: Salmon, E. D.
name: Yeh, E.
name: Lew, D. J.
name: Maddox, P.
name: Yang, C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: In the budding yeast Saccharomyces cerevisiae, movement of the mitotic spindle to a predetermined cleavage plane at the bud neck is essential for partitioning chromosomes into the mother and daughter cells. Astral microtubule dynamics are critical to the mechanism that ensures nuclear migration to the bud neck. The nucleus moves in the opposite direction of astral microtubule growth in the mother cell, apparently being “pushed” by microtubule contacts at the cortex. In contrast, microtubules growing toward the neck and within the bud promote nuclear movement in the same direction of microtubule growth, thus “pulling” the nucleus toward the bud neck. Failure of “pulling” is evident in cells lacking Bud6p, Bni1p, Kar9p, or the kinesin homolog, Kip3p. As a consequence, there is a loss of asymmetry in spindle pole body segregation into the bud. The cytoplasmic motor protein, dynein, is not required for nuclear movement to the neck; rather, it has been postulated to contribute to spindle elongation through the neck. In the absence of KAR9, dynein-dependent spindle oscillations are evident before anaphase onset, as are postanaphase dynein-dependent pulling forces that exceed the velocity of wild-type spindle elongation threefold. In addition, dynein-mediated forces on astral microtubules are sufficient to segregate a 2N chromosome set through the neck in the absence of spindle elongation, but cytoplasmic kinesins are not. These observations support a model in which spindle polarity determinants (BUD6, BNI1, KAR9) and cytoplasmic kinesin (KIP3) provide directional cues for spindle orientation to the bud while restraining the spindle to the neck. Cytoplasmic dynein is attenuated by these spindle polarity determinants and kinesin until anaphase onset, when dynein directs spindle elongation to distal points in the mother and bud.
PROFILAKTIK HISOBGA OLISH HUQUQBUZARLIKLAR YAKKA TARTIBDAGI PROFILAKTIKASINING MUHIM CHORASI (IXTISOSLASHTIRILGAN O'QUV-TARBIYA MUASSASALARIDAN QAYTGANLARGA SHAXSLAR MISOLIDA)
Creators: name: SAFAROV, JURABEK
Publisher: name: Zenodo
Year: 2025

description: Mamlakatimizda sog‘lom va barkamol avlodni tarbiyalashga, ma’naviy-axloqiy, jismonan yetuk, vatanparvar yoshlarni voyaga yetkazishga yo‘naltirilgan kompleks chora-tadbirlar amalga oshirilmoqda[1]. Ushbu tashabbuslar, yoshlarni milliy an’ana va qadriyatlarimizga sadoqatli, islohotlarning faol va jonkuyar ishtirokchilariga aylantirishga qaratilgan bo‘lib, jamiyatning kelajakda barqaror rivojlanishini ta’minlashda muhim ahamiyatga ega.
ZAMONAVIY TIBBIYOTDA DYUPYUITREN KONTRAKTURASI
Creators: name: Nazarova, N.Z.
name: Rashidov, J.T.
Publisher: name: Zenodo
Year: 2023

description: Dyupyuitren kontrakturasi - bu bir yoki bir nechta barmoqlarning doimiy ravishda bukilgan holatda bo'lishi bilan kechadigan klinik vaziyatdir. Chet el adabiyotlarida alohida holda "Dyupyuitren kasalligi" va "Dyupyuitren kontrakturasi" terminlari uchraydi. Shunga ko'ra bu ikki atamani bir-biridan farqlash lozim. Dyupyuitren kasalligi biriktiruvchi to'qimaning keng tarqalgan irsiy shikastlanishidir. U avloddan avlodga irsiylanadi, kaft va barmoq fassiyalari, shuningdek, ularga tutashgan biriktiruvchi to'qimalarda "yaxshi sifatli" fibrotik o'zgarishlarni keltirib chiqaradi. Dyupyuitren kasalligi yuqorida sanalgan to'qimalarning mexanik kuchlanish chizig'i bo'ylab qisqarishiga, barmoqlarda yozish harakatlarining cheklanishiga olib keladi.
Dynamics of Complex Systems Built as Coupled Physical, Communication and Decision Layers
Creators: name: Kühnlenz, Florian
name: Nardelli, Pedro H. J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Multiagent Systems (cs.MA)
subject: Social and Information Networks (cs.SI)
subject: Systems and Control (eess.SY)
subject: Physics and Society (physics.soc-ph)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Physical sciences

description: This paper proposes a simple model to capture the complexity of multi-layer systems where their constituent layers affect, are affected by, each other. The physical layer is a circuit composed by a power source and resistors in parallel. Individual agents can add, remove or keep the resistors they have, and their decisions aiming at maximising the delivered power - a non-linear function dependent on the others' behaviour - based on their internal state, their global state perception, the information received from their neighbours in the communication network, and a randomised selfishness. We develop an agent-based simulation to analyse the effects of number of agents (size of the system), communication network topology, communication errors and the minimum power gain that triggers a behavioural change. Our results show that a wave-like behaviour at macro-level (caused by individual changes in the decision layer) can only emerge for a specific system size, the ratio between cooperators and defectors depends on minimum gain assumed - lower minimal gains lead to less cooperation and vice-versa, different communication network topologies lead to different levels of power utilisation and fairness at the physical layer, and a certain level of error in the communication layer leads to more cooperation.
title: Unique types of intracranial and extracranial hemorrhage in the perinatal period: Review of etiologies and imaging findings
Creators: name: TAwfik, Ayah
Publisher: name: European Congress of Radiology
Year: 2022
Subjects: subject: Neuroradiology brain
subject: Paediatric
subject: CT
subject: MR
subject: Ultrasound
subject: Education
subject: Cerebral palsy
subject: Outcomes

description: Learning objectives Background Findings and procedure details Conclusion Personal information and conflict of interest References
description: Learning objectives: Review the common etiologies of intracranial hemorrhage in the neonatal period. Illustrate imaging findings and unique patterns of perinatal intracranial hemorrhage. Identify mimics of intracranial hemorrhage in neonates. Identify the pros and cons...
Dark Matter Triggers of Supernovae
Creators: name: Graham, Peter W.
name: Rajendran, Surjeet
name: Varela, Jaime
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The transit of primordial black holes through a white dwarf causes localized heating around the trajectory of the black hole through dynamical friction. For sufficiently massive black holes, this heat can initiate runaway thermonuclear fusion causing the white dwarf to explode as a supernova. The shape of the observed distribution of white dwarfs with masses up to $1.25 M_{\odot}$ rules out primordial black holes with masses $\sim 10^{19}$ gm - $10^{20}$ gm as a dominant constituent of the local dark matter density. Black holes with masses as large as $10^{24}$ gm will be excluded if recent observations by the NuStar collaboration of a population of white dwarfs near the galactic center are confirmed. Black holes in the mass range $10^{20}$ gm - $10^{22}$ gm are also constrained by the observed supernova rate, though these bounds are subject to astrophysical uncertainties. These bounds can be further strengthened through measurements of white dwarf binaries in gravitational wave observatories. The mechanism proposed in this paper can constrain a variety of other dark matter scenarios such as Q balls, annihilation/collision of large composite states of dark matter and models of dark matter where the accretion of dark matter leads to the formation of compact cores within the star. White dwarfs, with their astronomical lifetimes and sizes, can thus act as large space-time volume detectors enabling a unique probe of the properties of dark matter, especially of dark matter candidates that have low number density. This mechanism also raises the intriguing possibility that a class of supernova may be triggered through rare events induced by dark matter rather than the conventional mechanism of accreting white dwarfs that explode upon reaching the Chandrasekhar mass.
description: 16 pages, 3 figures
John Robert Lawrence Allen Bibliography, 1957 - 2022 (in chronological order) from JOHN ROBERT LAWRENCE ALLEN. 25 October 1932 — 18 October 2020
Creators: name: Worsley, Peter
name: Bell, Martin
name: Fulford, Michael
Publisher: name: The Royal Society
Year: 2023
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: John Allen was one of the leading British geologists of the late twentieth century, who changed his primary research focus in mid career from clastic sedimentology to geoarchaeology. He read for a BSc degree in geology at the University of Sheffield, graduating with first class honours in 1955. He continued at Sheffield as a postgraduate student researching the geology of the Old Red Sandstone of the Clee Hills in Shropshire, but never submitted a PhD thesis. However, in 1958 the University of Reading offered him a research fellowship to investigate the geology of the hydrocarbon-rich River Niger delta region. In 1961 he became a lecturer in geology and a member of the new purpose-built Sedimentology Research Laboratory at Reading. The international renown of the laboratory was largely based on his prodigious sedimentological research output relating to sedimentary structures, river and coastal environments and Devonian continental deposits. He was appointed reader in 1967 and professor in 1972. In 1974 he led the founding of a taught MSc course in ‘Sedimentology and its applications’, which soon became a world leader. In 1988, in the context of the rationalization of university geology departments, Reading's department was selected for closure. However, John Allen's research esteem was such that a special case was made and a postgraduate-only institute specializing in sedimentology was established with him as director. He resigned the directorship after five years in favour of a research professorship. His objectives changed from orthodox old-rock studies to research on recent muddy estuarine sediments. By selecting the estuary of the River Severn as his new field area, he soon realized that this opened up a rich area of collaboration with colleagues in archaeology. His geological skills were subsequently applied to a range of archaeological problems. He became a key contributor to a new MSc degree course in geoarchaeology.
Big Data Analytics on Traditional HPC Infrastructure Using Two-Level Storage
Creators: name: Xuan, Pengfei
name: Denton, Jeffrey
name: Ge, Rong
name: Srimani, Pradip K.
name: Luo, Feng
Publisher: name: arXiv
Year: 2015
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Computer and information sciences
subject: D.4.3

description: Data-intensive computing has become one of the major workloads on traditional high-performance computing (HPC) clusters. Currently, deploying data-intensive computing software framework on HPC clusters still faces performance and scalability issues. In this paper, we develop a new two-level storage system by integrating Tachyon, an in-memory file system with OrangeFS, a parallel file system. We model the I/O throughputs of four storage structures: HDFS, OrangeFS, Tachyon and two-level storage. We conduct computational experiments to characterize I/O throughput behavior of two-level storage and compare its performance to that of HDFS and OrangeFS, using TeraSort benchmark. Theoretical models and experimental tests both show that the two-level storage system can increase the aggregate I/O throughputs. This work lays a solid foundation for future work in designing and building HPC systems that can provide a better support on I/O intensive workloads with preserving existing computing resources.
description: Submitted to SC15, 8 pages, 7 figures, 3 tables
Radial excitations of mesons and nucleons from QCD sum rules
Creators: name: Jiang, Jin-Feng
name: Zhu, Shi-Lin
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Within the framework QCD sum rules, we use the least square fitting method to investigate the first radial excitations of the nucleon and light mesons such as $ρ$, $K^{*}$, $π$ , $φ$. The extracted masses of these radial excitations are consistent with the experimental data. Especially we find that the decay constant of $π(1300)$, which is the the first radial excitation of $π$, is tiny and strongly suppressed as a consequence of chiral symmetry.
description: 19 pages
Predicting serotonin toxicity in serotonin reuptake inhibitor overdose
Creators: name: Cooper, Joyce
name: Duffull, Stephen B.
name: Isbister, Geoffrey K.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology
subject: 110309 Infectious Diseases

description: We aimed to investigate the frequency of serotonin toxicity following overdose of antidepressants that inhibit serotonin reuptake and the factors that influence the probability of serotonin toxicity occurring. This was a retrospective cohort study of overdoses that included selective serotonin reuptake inhibitors (SSRIs) (70%) and serotonin norepinephrine reuptake inhibitors (SNRIs) (30%) admitted to a tertiary toxicology unit over 23 years. A multivariate mixed effects logistic regression model using NONMEM (7.2.0) was used to determine factors that influenced the probability of serotonin toxicity occurring. There were 1978 overdoses in 1520 patients; median age 33 y (range: 13–86 years) and 64% female. Median defined daily dose equivalent (DDD) was 15 (1–420). Co-ingestants were taken in 1678/1978 (85%) overdoses: 11 co-ingested the monoamine oxidase-A inhibitor (MAOI) moclobemide, 99 (5%) co-ingested olanzapine, 58 (3%) co-ingested risperidone and 417 co-ingested a benzodiazepine (21%). Serotonin toxicity occurred in 269 overdoses (13.6%). The probability of serotonin toxicity increased slightly per 10 DDD units dose [OR, 1.01; 95% confidence intervals (CIs): 0.93–1.10], increased for an SNRI vs. an SSRI [OR, 1.07; 95% CI: 0.99–1.15], and markedly increased with co-ingestion of moclobemide [OR, 33.12; 95% CI: 7.5–147]. The probability decreased per 10 y age [OR, 0.84; 95% CI: 0.74–0.95], and with co-ingestion of the serotonin 2 A receptor (5-HT2A) antagonists olanzapine [OR, 0.40; 95% CI: 0.17–0.94] or risperidone [OR, 0.13; 95% CI: 0.02–0.99]. The probability of serotonin toxicity was 12.5% at 1 DDD (therapeutic), 12.7% at 15 DDDs and 19% at 420 DDDs. In overdoses of the median dose of 15 DDDs, co-ingestion of moclobemide increased the probability to 83%, and co-ingestion of olanzapine or risperidone decreased it to 5.5% and 1.8%, respectively. Serotonin toxicity is common following SSRI/SNRI overdose. Although dose increases probability, this was only a small effect. Co-ingestion with olanzapine or risperidone reduced the risk 2–6-fold, and moclobemide increased the risk 5-fold.
Evidence for Functional Differentiation among Drosophila Septins in Cytokinesis and Cellularization
Creators: name: Pringle, J. R.
name: Peifer, M.
name: Adam, J. C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2000

description: The septins are a conserved family of proteins that are involved in cytokinesis and other aspects of cell-surface organization. In Drosophila melanogaster, null mutations in the pnut septin gene are recessive lethal, but homozygous pnut mutants complete embryogenesis and survive until the pupal stage. Because the completion of cellularization and other aspects of early development seemed likely to be due to maternally contributed Pnut product, we attempted to generate embryos lacking the maternal contribution in order to explore the roles of Pnut in these processes. We used two methods, the production of germline clones homozygous for a pnut mutation and the rescue of pnut homozygous mutant flies by a pnut+ transgene under control of the hsp70 promoter. Remarkably, the pnut germline-clone females produced eggs, indicating that stem-cell and cystoblast divisions in the female germline do not require Pnut. Moreover, the Pnut-deficient embryos obtained by either method completed early syncytial development and began cellularization of the embryo normally. However, during the later stages of cellularization, the organization of the actin cytoskeleton at the leading edge of the invaginating furrows became progressively more abnormal, and the embryos displayed widespread defects in cell and embryo morphology beginning at gastrulation. Examination of two other septins showed that Sep1 was not detectable at the cellularization front in the Pnut-deficient embryos, whereas Sep2 was still present in normal levels. Thus, it is possible that Sep2 (perhaps in conjunction with other septins such as Sep4 and Sep5) fulfills an essential septin role during the organization and initial ingression of the cellularization furrow even in the absence of Pnut and Sep1. Together, the results suggest that some cell-division events in Drosophila do not require septin function, that there is functional differentiation among the Drosophila septins, or both.
Fast numerical evaluation of time-derivative nonadiabatic couplings for mixed quantum-classical methods
Creators: name: Ryabinkin, Ilya G.
name: Nagesh, Jayashree
name: Izmaylov, Artur F.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: We have developed a numerical differentiation scheme which eliminates evaluation of overlap determinants in calculating the time-derivative non-adiabatic couplings (TDNACs). Evaluation of these determinants was the bottleneck in previous implementations of mixed quantum-classical methods using numerical differentiation of electronic wave functions in the Slater-determinant representation. The central idea of our approach is, first, to reduce the analytic time derivatives of Slater determinants to time derivatives of molecular orbitals, and then to apply a finite-difference formula. Benchmark calculations prove the efficiency of the proposed scheme showing impressive several-order-of-magnitude speedups of the TDNAC calculation step for midsize molecules.
description: 4 pages