cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Focchi - Wood-based curtain wall façade system
Creators: name: Jancke, Oliver
name: Grosse, Charlotte
name: Kuijl, Florence
name: Vandi, Laura
name: Pracucci, Alessandro
Publisher: name: Zenodo
Year: 2023
Subjects: modular façade
biobased material
circular design
wood construction
circular economy

description: Façade System with multi-layer bio-composites, Basajaun Fact Sheet
ТРИТИКАЛЕ МОРФОЛОГИЯСИ ВА УНИНГ КЕЛИБ ЧИҚИШИ
Creators: name: Ақида Авлақуловна Эшмуродова
name: Акмал Қаландар Ўғли Бўронов
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: тритикале
тетраплоид
колеоптиле
ҳосилдорлик
селекция
сифат кўрсаткичлари.
triticale
tetraploid
coleoptile
yield
selection
quality indicators.

description: Ушбу мақолада тритикале экини яратилиши ва морфохўжалик ҳамда ҳосилдорлик кўрсаткичлари устида дунёда олиб борилаётган тадқиқотларни адабиётлар таҳлили бўйича олинган маълумотлар ёритиб берилган
description: This article describes the data obtained from the analysis of the literature of the world's research on the creation of triticale and morphological and productivity indicators.
ТУРКИЙ ТИЛЛАРДАН ВА ЎЗБЕК ТИЛИДАН РУС ТИЛИГА ЎЗЛАШГАН СЎЗЛАРИНИНГ ТАРИХИЙ КИЕСИЙ ТАДҚИҚИ
Creators: name: Нигора Сабировна Ахрарова
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: тил
ходиса
фарқ
исбот
тараққиѐт

description: Тил фактларини қиѐслаш оддий таққослашдан иборат бўлмаслиги учун туркий тилларга хос барча ҳодисалар диахрон планда ўрганилади. Зеро, туркий тилларнинг фонетик ва грамматик хусусиятларини ўзаро қиѐслашни тарихий талқинсиэ амалга ошириб бўлмайди. Ҳозирги туркий тилларга хос айрим грамматик ҳолатлар синхрон асосда ҳам ѐритилади. Жумладан, туркий тилларнинг фонетик тизимида рўи берган ўзгаришлар, унли ва ундошларнинг мослиги масаласи, товушларнинг талаффузи, ѐзилишидаги фаркларни ажрата олиш туфайли у ѐки бу тилга оид матнни ўрганиш мумкин бўлади. Ҳар бир тил қариндош ѐки қариндош бўлмаслигидан қатьи наэар бошқа тилнинг таъсирига учрамай қолмайди. Кўпгина, хусусан, собиқ шўро ҳукмронлиги таъсирида қолган туркий тилларнинг тараққиѐтига фақатгина қариндош тиллдр эмас, балки рус тили, шунингдек, урал —олтой тилларининг ҳам таъсири сезиларли даражада бўлган. Шунга кўра, муайян туркий тилдаги ҳодисаларни изоҳлашда юқорида айтилгаи гиллар билан қиеслашга ҳам ўрин берилади. Қиѐслаб ўрганиш жараенида туркий тиллар бошқа урал —олтой тиллари билан бирга ягона система сифатида олйнади. Чунки грамматик шакллар генезисини ѐритишда бу 1рамматик ҳодисаларнинг ўзаро таъсири иа боғлиқлигини ҳисобга олиб, чуқур систем — структур таҳлил амалга оширилиши, уларнинг шаклланиши ва ўзгаришларини аниқ мантиқий фикрлаш орқали исботлаш керак бўлади. Бу эса туркий тилларга хос грамматик шаклларнинг тараққиѐти ва умумий тузилиш моделини кўрсатиш имкониятини яратади.
Comparative susceptibility of Plasmodium ovale and Plasmodium falciparum field isolates to reference and lead candidate antimalarial drugs in Ghana.
Creators: name: Aniweh, Yaw
name: Soulama, Alamissa
name: Chirawurah, Jersley
name: Ansah, Felix
name: Danwonno, Harry A
name: Sogore, Fanta
name: Rouillier, Melanie
name: Campo, Brice
name: Amenga-Etego, Lucas
name: Djimde, Abdoulaye A
name: Awandare, Gordon A
name: Dembele, Laurent
Publisher: name: The Francis Crick Institute
Year: 2023
Subjects: Infectious Disease

description: Malaria treatments resulted in the decline of the deadliest Plasmodium falciparum globally while species, such as P. ovale, infections have been increasingly detected across sub-Saharan Africa. Currently, no experimental drug sensitivity data are available to guide effective treatment and management of P. ovale infections, which is necessary for effective malaria elimination. We conducted a prospective study to evaluate P. ovale epidemiology over 1 year and determined ex vivo susceptibility of the field isolates to existing and lead advanced discovery antimalarial drugs. We report that while P. falciparum dominated both symptomatic and asymptomatic malaria cases, P. ovale in mono or co-infections caused 7.16% of symptomatic malaria. Frontline antimalarials artesunate and lumefantrine inhibited P. ovale as potently as P. falciparum. Chloroquine, which has been withdrawn in Ghana, was also highly inhibitory against both P. ovale and P. falciparum. In addition, P. ovale and P. falciparum displayed high susceptibility to quinine, comparable to levels observed with chloroquine. Pyrimethamine, which is a major drug for disease massive prevention, also showed great inhibition of P. ovale, comparable to effects on P. falciparum. Furthermore, we identified strong inhibition of P. ovale using GNF179, a close analogue of KAF156 imidazolopiperazines, which is a novel class of antimalarial drugs currently in clinical phase II testing. We further demonstrated that the Plasmodium phosphatidylinositol-4-OH kinase (PI4K)-specific inhibitor, KDU691, is highly inhibitory against P. ovale and P. falciparum field isolates. Our data indicated that existing and lead advanced discovery antimalarial drugs are suitable for the treatment of P. ovale infections in Ghana. IMPORTANCE Current malaria control and elimination tools such as drug treatments are not specifically targeting P.ovale. P. ovale can form hypnozoite and cause relapsing malaria. P. ovale is the third most dominant species in Africa and requires radical cure treatment given that it can form liver dormant forms called hypnozoites that escape all safe treatments. The inappropriate treatment of P. ovale would sustain its transmission in Africa where the medical need is the greatest. This is a hurdle for successful malaria control and elimination. Here, we provided experiment data that were lacking to guide P. ovale treatment and disease control policy makers using reference antimalarial drugs. We also provided key experimental data for 2 clinical candidate drugs that can be used for prioritization selection of lead candidate's identification for clinical development.
ЎЗБЕК ТИЛИДА СИФАТГА ОИД ЛЕКСЕМАЛАРНИНГ ЛИНГВОКУЛЬТУРОЛОГИК ТАДҚИҚИ МАСАЛАЛАРИ
Creators: name: Нафиса Рахматулаевна Аманликова
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: сифат
лексема
тадқиқ
тил.

description: Жаҳон тилшунослигида сўнгги йилларда амалга оширилаѐтган илмий тадқиқотларда лисоний ҳодисаларнинг моҳиятини очишда инсон омилини ҳисобга олиш анъанаси етакчилик қилмоқда. Антропоцентрик парадигма асосида семантикага оид тадқиқотлар ҳам сифат ўзгаришларига учради. Лексик бирликларнинг маъно хусусиятлари таҳлилида инсон омилининг ўрни, белгиловчи аҳамиятини ўрганиш кун тартибига қўйилди. Дунѐ олимлари инсониятнинг тафаккур тарзи билан боғлиқ абстракт сўзларни нафақат лингво-фалсафий ва грамматик нуқтаи назарлардан, балки антропоцентрик ѐндашув асосида ҳам ўрганмоқдалар. Бир қатор илмий ишларда абстракт номлар ментал, семантикконцептуал жиҳатдан тадқиқ қилинган бўлиб, мазкур бирликлар бўйича аксиологик, ассоциатив, лингвокультурологик тадқиқотларнинг ҳам амалга оширилиши бугунги тилшунослик учун аҳамиятлидир. Зеро, маънавий жиҳатдан инсоният эришган барча ютуқларни номловчи сўзларнинг тадқиқида муайян тил эгаларининг ўзига хос тафаккури, маънавияти ва маданияти акс этади.
Fraunhofer WKI - Thermoplastic composite sheet
Creators: name: Grosse, Charlotte
name: Jancke, Oliver
name: Kuijl, Florence
name: Schirp, Arne
Publisher: name: Zenodo
Year: 2023
Subjects: biobased material
thermoplastic composite sheet
circular economy
wood construction

description: Thermoplastic composite sheet from recycled wood and biopolymers, Basajaun Results in Brief
Liquid Biopsy: Seeking for Cancer Cells
Creators: name: Pui-Ock, Sittisak
Publisher: name: Zenodo
Year: 2023
Subjects: circulating tumor cells, CTCs, liquid biopsy

description: Over the past ten years, interest in new techniques for cancer diagnosis and monitoring has increased. One of these techniques is the use of blood samples from cancer patients. These blood samples are referred to Liquid Biopsy (LB). One type of liquid biopsy that is simple to obtain from a patient is Circulating Tumor Cells (CTCs). CTCs are cancer cells that have detached from the primary tumor of the organ where the cancer first appeared and entered the bloodstream before spreading to other organs to develop into secondary tumors. The evaluation of the chemical and/or radiological treatment or the monitoring of cancer recurrence following surgery can both be facilitated by the identification of CTCs in the blood of cancer patients. In other words, it is anticipated that it will serve as the starting point for personalized targeted therapy, which will allow patients to receive targeted treatment and show favorable outcomes on an individual basis, increasing their chances of surviving for a longer time.
ЎҚУВЧИЛАРНИ ВАТАНПАРВАРЛИК РУҲИДА ТАРБИЯЛАШДА МАКТАБ ВА ОИЛАНИНГ АҲАМИЯТИ
Creators: name: О. К. Мирзорахимов
name: И. Б. Мадрахимова
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: Ватан
ватанпарварлик
муҳаббат
хафсизлик
маданият
хизмат қилиш
Ватанга мухаббат
ҳимоя қилиш

description: Мақолада ўқитувчининг ва оиланинг ўқувчиларни ватанпарварлик руҳида тарбиялашдаги моҳияти ҳақида сўз юритилган
title: Sex, politics and society : The regulation of sexuality since 1800.
Creators: name: Weeks, Jeffrey
Publisher: name: University of Kent
Year: 2023

description: This work is, in essence, a discussion of the forces that have organised and regulated sexuality within a particular historical period (roughly the period of industrial capitalism) in a particular geographical and political area (Great Britain, and chiefly that part south of Scotland) Its working premise, set out in some detail in Chapter 1, is that 'sexuality' is not an unproblematic natural given, which the 'social' works upon to control, but is, on the contrary, an historical unity which has been shaped and determined by a multiplicity of forces, and which has undergone complex historical transformations. The argument revolves around three broad issues: the meaning given to sexuality in Victorian society; the construction of sexuality as an area of social concern, scientific investigation and reforming endeavour in the late nineteenth and early twentieth centuries; and the place of sexuality in twentieth-century consciousness and social policy. In tackling these questions I am aware that I have ignored other domains of interest, and have bypassed other questions that might fruitfully have been discussed. My excuse is that my aim has been a modest, but I believe vitally important, one: to delineate the forces, ideas and social practices that have elevated sexuality into a prime focus of social concern over the past two hundred years.
The transcriptional co-activator Yap1 promotes adult hippocampal neural stem cell activation.
Creators: name: Fan, Wenqiang
name: Jurado-Arjona, Jerónimo
name: Alanis-Lobato, Gregorio
name: Péron, Sophie
name: Berger, Christian
name: Andrade-Navarro, Miguel A
name: Falk, Sven
name: Berninger, Benedikt
Publisher: name: The Francis Crick Institute
Year: 2023
Subjects: subject: Developmental Biology
subject: Stem Cells
subject: Neurosciences
subject: FOS: Clinical medicine
subject: Genetics & Genomics

description: Most adult hippocampal neural stem cells (NSCs) remain quiescent, with only a minor portion undergoing active proliferation and neurogenesis. The molecular mechanisms that trigger the transition from quiescence to activation are still poorly understood. Here, we found the activity of the transcriptional co-activator Yap1 to be enriched in active NSCs. Genetic deletion of Yap1 led to a significant reduction in the relative proportion of active NSCs, supporting a physiological role of Yap1 in regulating the transition from quiescence to activation. Overexpression of wild-type Yap1 in adult NSCs did not induce NSC activation, suggesting tight upstream control mechanisms, but overexpression of a gain-of-function mutant (Yap1-5SA) elicited cell cycle entry in NSCs and hilar astrocytes. Consistent with a role of Yap1 in NSC activation, single cell RNA sequencing revealed a partial induction of an activated NSC gene expression program. Furthermore, Yap1-5SA expression also induced expression of Taz and other key components of the Yap/Taz regulon that were previously identified in glioblastoma stem cell-like cells. Consequently, dysregulated Yap1 activity led to repression of hippocampal neurogenesis, aberrant cell differentiation, and partial acquisition of a glioblastoma stem cell-like signature.
ЭКОЛОГИK ХАВФСИЗЛИКНИ ОШИРИШ УЧУН МУҚОБИЛ ЁНИЛҒИЛАРДАН ФОЙДАЛАНИШ ХУСУСИЯТЛАРИ
Creators: name: Шерали Абдуманнонович Суванқулов
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: автомобил
биометан
экология
эксплуатация
ѐқилғи сарфи
эксплуатацион кўрсаткичлар
энергия
органик ўғитлар
калория
automotive
biomethane
ecology
operation
fuel consumption
performance
energy
organic fertilizers
calories

description: Ушбу мақолада автомобил транспортида ѐқилғи сифатида ишлатиладиган биометаннинг автомобилда қўлланилганда экологияга таъсирини автомобил ҳаракат тезлигининг ўзгариш хусусиятларига боғлиқ ҳолда таҳлил қилинган
description: This article analyzes the environmental impact of biomethane used as a fuel in road transport in relation to the characteristics of changes in vehicle speed.
ЭКОЛОГИЧЕСКАЯ ПРОБЛЕМА СОВРЕМЕННОСТИ КАК ГЛОБАЛЬНАЯ ПРОБЛЕМА ЧЕЛОВЕЧЕСТВА
Creators: name: Фируза Рахматовна Камалова
name: Шохиста Абдурашидовна Холова
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: проблемы
обострение
увеличение
загрязнение
ухудшение
ресурсы
планета.
problems
exacerbation
increase
pollution
deterioration
resources
planet.

description: В данной статье рассматриваются основные виды глобальных экологических проблем как актуальные для всей планеты кризисные экологические ситуации, решение которых возможно только при участии всего человечества. Глобальные экологические проблемы тесно связаны с другими глобальными мировыми проблемами, они влияют друг на друга и возникновение одних приводит к возникновению или обострению других. В статье отмечается, что такая сложная мировая проблема, как демографическая, вызванная взрывным ростом населения земного шара, приводит к резкому увеличению нагрузки на окружающую среду из-за увеличения потребностей людей в продуктах питания, энергии, жилье, промышленных товарах, и др. В данной статье мы определили, что деградация окружающей среды приводит к значительным экономическим издержкам в результате деградации природных ресурсов, загрязнения окружающей среды, ухудшения здоровья населения.
description: This article discusses the main types of global environmental problems as critical environmental situations for the entire planet, the solution of which is possible only with the participation of all mankind. Global environmental problems are closely related to other global world problems, they influence each other and the occurrence of one leads to the emergence or exacerbation of others. The article notes that such a complex global problem as demographic, caused by the explosive growth of the world's population, leads to a sharp increase in the burden on the environment due to the increase in people's needs for food, energy, housing, manufactured goods, etc. In this In this article we determined that environmental degradation leads to significant economic costs as a result of the degradation of natural resources, environmental pollution, and deterioration in public health
ЭТИМОЛОГИЧЕСКИЙ И СЛОВООБРАЗОВАТЕЛЬНЫЙ АНАЛИЗ ГИДРОНИМОВ В АНГЛИЙСКОМ И РУССКОМ ЯЗЫКАХ
Creators: name: Надира Бекбергеновна Палванова
Publisher: name: Academic research in educational sciences
Year: 2022
Subjects: Гидроним
возможность
народ
качетва

description: Гидронимика (греч. hydor'вода', onyma 'имя') является одним из важнейших разделов топонимики, изучение которой имеет большое научнотеоретическое и практическое значение. Исследование гидронимии отдельного региона дает возможность выявлению новых факторов по истории, географии, этнографии того или иного народа. Будучи самым древним пластом топонимики, гидронимы не просто выполняют номинативную функцию, они часто отражают национальные качества, обычаи и традиции, поскольку тесно связаны с жизнью народа.
Supporting formation for "Omphacite melting and the destruction of early high-pressure rock records"
Creators: name: Liu, Shuaiqi
name: Zhang, Guibin
name: Zhang, Lifei
name: Alexander G. Webb, A.
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 370599
subject: Geology not elsewhere classified

description: Supporting information includes eight tables and eight figures
Supporting formation for "High-pressure eclogite melting in the central Himalaya: Timing, tectono-thermal regime, and implications for continental growth"
Creators: name: Liu, Shuaiqi
name: Zhang, Guibin
name: Zhang, Lifei
name: Alexander G. Webb, A.
Publisher: name: figshare
Year: 2022
Subjects: classificationCode: 370599
subject: Geology not elsewhere classified

description: Supplementary files including twelve tables and ten figures
The COVID-19, tuberculosis and HIV/AIDS: Ménage à Trois.
Creators: name: Udoakang, Aniefiok John
name: Zune, Alexandra Lindsey Djomkam
name: Tapela, Kesego
name: Nganyewo, Nora Nghochuzie
name: Olisaka, Frances Ngozi
name: Anyigba, Claudia Adzo
name: Tawiah-Eshun, Sylvia
name: Owusu, Irene Amoakoh
name: Paemka, Lily
name: Awandare, Gordon A
name: Quashie, Peter Kojo
Publisher: name: The Francis Crick Institute
Year: 2023
Subjects: Infectious Disease

description: In December 2019, a novel pneumonic condition, Coronavirus disease 2019 (COVID- 19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), broke out in China and spread globally. The presentation of COVID-19 is more severe in persons with underlying medical conditions such as Tuberculosis (TB), Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) and other pneumonic conditions. All three diseases are of global concern and can significantly affect the lungs with characteristic cytokine storm, immunosuppression, and respiratory failure. Co-infections of SARS-CoV-2 with HIV and Mycobacterium tuberculosis (Mtb) have been reported, which may influence their pathogenesis and disease progression. Pulmonary TB and HIV/AIDS patients could be more susceptible to SARS-CoV-2 infection leading to lethal synergy and disease severity. Therefore, the biological and epidemiological interactions of COVID-19, HIV/AIDS, and TB need to be understood holistically. While data is needed to predict the impact of the COVID-19 pandemic on these existing diseases, it is necessary to review the implications of the evolving COVID-19 management on HIV/AIDS and TB control, including therapy and funding. Also, the impact of long COVID on patients, who may have this co-infection. Thus, this review highlights the implications of COVID-19, HIV/AIDS, and TB co-infection compares disease mechanisms, addresses growing concerns, and suggests a direction for improved diagnosis and general management.
New immunological potential markers for triple negative breast cancer: IL18R1, CD53, TRIM, Jaw1, LTB, PTPRCAP.
Creators: name: Marchetti, Paolo
name: Antonov, Alexey
name: Anemona, Lucia
name: Vangapandou, Chaitania
name: Montanaro, Manuela
name: Botticelli, Andrea
name: Mauriello, Alessandro
name: Melino, Gerry
name: Catani, M Valeria
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Research
Triple negative breast cancer
IL18R1
CD53
TRIM
Jaw1
LTB
PTPRCAP
Prognostic markers
Precision oncology
Cancer immunity

description: Breast cancer (BC) is the second leading cause of cancer death in women worldwide, and settings of specific prognostic factors and efficacious therapies are made difficult by phenotypic heterogeneity of BC subtypes. Therefore, there is a current urgent need to define novel predictive genetic predictors that may be useful for stratifying patients with distinct prognostic outcomes. Here, we looked for novel molecular signatures for triple negative breast cancers (TNBCs). By a bioinformatic approach, we identified a panel of genes, whose expression was positively correlated with disease-free survival in TNBC patients, namely IL18R1, CD53, TRIM, Jaw1, LTB, and PTPRCAP, showing specific immune expression profiles linked to survival prediction; most of these genes are indeed expressed in immune cells and are required for productive lymphocyte activation. According to our hypothesis, these genes were not, or poorly, expressed in different TNBC cell lines, derived from either primary breast tumours or metastatic pleural effusions. This conclusion was further supported in vivo, as immuno-histochemical analysis on biopsies of TNBC invasive ductal carcinomas highlighted differential expression of these six genes in cancer cells, as well as in intra- and peri-tumoral infiltrating lymphocytes. Our data open to the possibility that inter-tumour heterogeneity of immune markers might have predictive value; further investigations are recommended in order to establish the real power of cancer-related immune profiles as prognostic factors.
Kings Cross Knowledge Quarter
Creators: name: Skinner, David
name: Brown, Will
Publisher: name: Anglia Ruskin Research Online (ARRO)
Year: 2024
Subjects: classificationCode: 3999
subject: Other Education
subject: FOS: Educational sciences

description: This London-based walk connects and compares the campus with developments in the life sciences taking place at the other end of the Cambridge to London trainline.
Photonsphere, shadow, quasinormal modes, and greybody bounds of non-rotating Simpson-Visser black hole
Creators: name: Jha, Sohan Kumar
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this manuscript, we study photonsphere, shadow, quasinormal modes, Hawking temperature, and greybody bounds of a non-rotating Simpson-Visser black hole which is a regular black hole. We observe that though the radius of the photonsphere does depend on the Simpson-Visser parameter $α$, the shadow radius is independent of it. The shadow radius is found to be equal to that for Schwarzschild black hole. We, then, study quasinormal frequencies of the Simpson-Visser black hole for scalar and electromagnetic perturbations with the help of $6$th order WKB method. We tabulate values of quasinormal frequencies for various values of $α$, angular momentum $\ell$, and overtone number $n$. We also graphically show the dependence of real and imaginary parts of quasinormal frequency on $α$ and $\ell$. Additionally, We study the convergence of the WKB method for various values of pair $(n,\ell)$. Finally, we shed light on the dependence of the Hawking temperature on the parameter $α$ and the dependence of greybody bounds on $α$ and $\ell$.
CoReCon: an open, community-powered collection of Reionization constraints
Creators: name: Garaldi, Enrico
Publisher: name: arXiv
Year: 2023
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: The number of available constraints on the Universe during and before cosmic reionization is rapidly growing. These are often scattered across inhomogeneous formats, unit systems and sampling strategies. In this paper, I introduce CoReCon, a Python package designed to provide a growing set of constraints on key physical quantities related to the Epoch of Reionization and a platform for the high-redshift research community to collect and store, in an open way, current and forthcoming observational constraints.
description: Published in the Journal of Open Source Software
RackBlox: A Software-Defined Rack-Scale Storage System with Network-Storage Co-Design
Creators: name: Reidys, Benjamin
name: Xue, Yuqi
name: Li, Daixuan
name: Sukhwani, Bharat
name: Hwu, Wen-mei
name: Chen, Deming
name: Asaad, Sameh
name: Huang, Jian
Publisher: name: arXiv
Year: 2023
Subjects: subject: Operating Systems (cs.OS)
subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Software-defined networking (SDN) and software-defined flash (SDF) have been serving as the backbone of modern data centers. They are managed separately to handle I/O requests. At first glance, this is a reasonable design by following the rack-scale hierarchical design principles. However, it suffers from suboptimal end-to-end performance, due to the lack of coordination between SDN and SDF. In this paper, we co-design the SDN and SDF stack by redefining the functions of their control plane and data plane, and splitting up them within a new architecture named RackBlox. RackBlox decouples the storage management functions of flash-based solid-state drives (SSDs), and allow the SDN to track and manage the states of SSDs in a rack. Therefore, we can enable the state sharing between SDN and SDF, and facilitate global storage resource management. RackBlox has three major components: (1) coordinated I/O scheduling, in which it dynamically adjusts the I/O scheduling in the storage stack with the measured and predicted network latency, such that it can coordinate the effort of I/O scheduling across the network and storage stack for achieving predictable end-to-end performance; (2) coordinated garbage collection (GC), in which it will coordinate the GC activities across the SSDs in a rack to minimize their impact on incoming I/O requests; (3) rack-scale wear leveling, in which it enables global wear leveling among SSDs in a rack by periodically swapping data, for achieving improved device lifetime for the entire rack. We implement RackBlox using programmable SSDs and switch. Our experiments demonstrate that RackBlox can reduce the tail latency of I/O requests by up to 5.8x over state-of-the-art rack-scale storage systems.
description: 14 pages. Published in published in ACM SIGOPS 29th Symposium on Operating Systems Principles (SOSP'23)
Vortex Fiber Nulling for Exoplanet Observations: Implementation and First Light
Creators: name: Echeverri, Daniel
name: Xuan, Jerry
name: Jovanovic, Nemanja
name: Ruane, Garreth
name: Delorme, Jacques-Robert
name: Mawet, Dimitri
name: Mennesson, Bertrand
name: Serabyn, Eugene
name: Wallace, J. Kent
name: Wang, Jason
name: Ruffio, Jean-Baptiste
name: Finnerty, Luke
name: Xin, Yinzi
name: Millar-Blanchaer, Maxwell
name: Baker, Ashley
name: Bartos, Randall
name: Calvin, Benjamin
name: Cetre, Sylvain
name: Doppmann, Greg
name: Fitzgerald, Michael P.
name: Hillman, Sofia
name: Horstman, Katelyn
name: Hsu, Chih-Chun
name: Liberman, Joshua
name: Lopez, Ronald
name: Morris, Evan
name: Pezzato, Jacklyn
name: Phillips, Caprice L.
name: Ren, Bin B.
name: Sappey, Ben
name: Schofield, Tobias
name: Skemer, Andrew J.
name: Vancil, Connor
name: Wang, Ji
Publisher: name: arXiv
Year: 2023
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Vortex fiber nulling (VFN) is a single-aperture interferometric technique for detecting and characterizing exoplanets separated from their host star by less than a diffracted beam width. VFN uses a vortex mask and single mode fiber to selectively reject starlight while coupling off-axis planet light with a simple optical design that can be readily implemented on existing direct imaging instruments that can feed light to an optical fiber. With its axially symmetric coupling region peaking within the inner working angle of conventional coronagraphs, VFN is more efficient at detecting new companions at small separations than conventional direct imaging, thereby increasing the yield of on-going exoplanet search campaigns. We deployed a VFN mode operating in K band ($2.0{-}2.5~μ$m) on the Keck Planet Imager and Characterizer (KPIC) instrument at the Keck II Telescope. In this paper we present the instrument design of this first on-sky demonstration of VFN and the results from on-sky commissioning, including planet and star throughput measurements and predicted flux-ratio detection limits for close-in companions. The instrument performance is shown to be sufficient for detecting a companion $10^3$ times fainter than a $5^{\mathrm{th}}$ magnitude host star in 1 hour at a separation of 50 mas (1.1$λ/D$). This makes the instrument capable of efficiently detecting substellar companions around young stars. We also discuss several routes for improvement that will reduce the required integration time for a detection by a factor ${>}$3.
description: 26 pages, 5 figures; Accepted to JATIS
Supplementary document for Generation of Bloch Surface Beams with Arbitrarily Designed Phases - 6468642.pdf
Creators: name: xiang, yifeng
name: Lu, Qijing
name: Wang, Ruxue
Publisher: name: Optica Publishing Group
Year: 2023
Subjects: Uncategorized

description: The dispersion relation of the BSW and internal modes; Excited BSW field of a single hole; Diffraction intensity for different excitation methods; Diffracted BSW field for a periodic array.
Well-posedness of Constrained Evolutionary Differential Variational-Hemivariational Inequalities
Creators: name: Migorski, S.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: A system of a first order history-dependent evolutionary variational-hemivariational inequality with unilateral constraints coupled with a nonlinear ordinary differential equation in a Banach space is studied. Based on a fixed point theorem for history dependent operators, results on the well-posedness of the system are proved. Existence, uniqueness, continuous dependence of the solution on the data, and the solution regularity are established. Two applications of dynamic problems from contact mechanics illustrate the abstract results. First application is a unilateral viscoplastic frictionless contact problem which leads to a hemivariational inequality for the velocity field, and the second one deals with a viscoelastic frictional contact problem which is described by a variational inequality.
description: 27 p
Supplemental Data from Duration invariance and intensity dependence of the human circadian system phase shifting response to brief light flashes
Creators: name: Joyce, Daniel S.
name: Spitschan, Manuel
name: Zeitzer, Jamie M.
Publisher: name: The Royal Society
Year: 2022
Subjects: subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences

description: Three supplemental figures
Machine Translation Models Stand Strong in the Face of Adversarial Attacks
Creators: name: Burnyshev, Pavel
name: Kostenok, Elizaveta
name: Zaytsev, Alexey
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computation and Language (cs.CL)
subject: Cryptography and Security (cs.CR)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Adversarial attacks expose vulnerabilities of deep learning models by introducing minor perturbations to the input, which lead to substantial alterations in the output. Our research focuses on the impact of such adversarial attacks on sequence-to-sequence (seq2seq) models, specifically machine translation models. We introduce algorithms that incorporate basic text perturbation heuristics and more advanced strategies, such as the gradient-based attack, which utilizes a differentiable approximation of the inherently non-differentiable translation metric. Through our investigation, we provide evidence that machine translation models display robustness displayed robustness against best performed known adversarial attacks, as the degree of perturbation in the output is directly proportional to the perturbation in the input. However, among underdogs, our attacks outperform alternatives, providing the best relative performance. Another strong candidate is an attack based on mixing of individual characters.
The relation of The comedy of errors to Plautine sources
Creators: name: Gill, Erma May
Publisher: name: The University of Texas at Austin
Year: 1929
Subjects: subject: Shakespeare
subject: Comedy of errors
subject: Sources
subject: Plautus
subject: Menaechmi
subject: Amphitruo
subject: Shakespeare, William, 1564-1616--Comedy of errors--Sources
subject: Shakespeare, William, 1564-1616--Comedy of errors
subject: Plautus, Titus Maccius--Menaechmi
subject: Plautus, Titus Maccius--Amphitruo

description: Recent interest in The Comedy of Errors has brought forth two editions of that play, the new Cambridge edition, by Sir Arthur Quiller-Couch and Professor J. Dover Wilson, in 1922, and the Yale edition by Professor Robert D. French, in 1926. A study by Professor Allison Gaw, "The Evolution of The Comedy of Errors," appeared in Publications of the Modern Language Association, September, 1926. Thus the entire problem of Shakespeare's sources for this play has been raised anew; the Cambridge editors and Professor Gaw strongly champion the theory that Shakespeare in The Comedy of Errors was revising an old play, which was entered on the Accounts of the Revels for 1576/77 as the Historie of Error, but of which nothing but the name survives. Professor French, in his brief introduction, takes a neutral stand on the question, but warns the reader that there is no actual proof that an old play based on the Menaechmi and the Amphitruo of Plautus, such as has been postulated, ever existed. Personally I had become interested in this subject before Professor Gaw's article was published, and his article has led me to further investigation. The result of this investigation has been the study of the entire relation of Shakespeare's play to the Plautine sources
BO'LAJAK INGLIZ TILI O'QITUVCHILARNING DARSLARIDA MULTIMEDIA VOSITALARI ORQALI FIKRLARNI ANIQ IFODALASH METODIKASINI TAKOMILLASHTIRISH.
Creators: name: Roʻziyeva, S.H.
name: Xakimova, Shaxinabonu
Publisher: name: Zenodo
Year: 2024

description: Ayni paytda ingliz tilini òrganish va òrgatishga bòlgan ehtiyoj kundan kunga ortib bormoqda. Ingliz tilini òrgatish jarayonida barcha pedagoglar kòplab multimedia vositalari bilan birga yangicha metodlarni ham òylab chiqishmoqda. Òqituvchilar eng sònggi texnologiya vositalari orqali yosh avlodni darsga qiziqtirishga va òz fikrlarini ifoda etishga undashyapti.
Automatic detection of solar flares observed at 45 GHz by the POEMAS telescope
Creators: name: Lessa, Vanessa
name: Valio, Adriana
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Every 11 years, the Sun goes through periods of activity, with the occurrence of many solar flares and mass ejections, both energetic phenomena of magnetic origin. Due to its effects on Earth, the study of solar activity is of paramount importance. POEMAS (Polarization of Millimeter Emission of Solar Activity) is a system of two telescopes, installed at CASLEO (El Leoncito Astronomical Complex) in Argentina, which monitors the Sun at two millimeter wavelengths (corresponding frequencies of 45 and 90 GHz). The objective of this work is to automatically detect solar flares observed by the polarimeter. First it is necessary to eliminate the background noise, caused mainly by instrumental problems, from the light curves of millimeter solar emission. The methodology used to exclude the noise proposed in this work is to use the tendency of time series. The subtraction of this model from the light curves provides the input to automate the detection of solar flares using artificial intelligence techniques. A Neural Network was trained to recognize patterns and analyze a dataset in order to identify solar flares. Previously, a total of 30 flares had been visually identified and analyzed in the POEMAS database between 2011/11/22 and 2013/12/10. The methodology presented here confirmed 87% of these events, moreover the neural network was able to identify at least 9 new events. As the neural network was trained to detect impulsive events (lasting less than 5 min), long duration bursts were not automatically detected, nor were they detected visually due to the background noise of the telescope. Visual inspection of the POEMAS data, when comparing with microwave data from the RSTN, allowed the identification of an additional 10 long-duration solar flares at 45 GHz. We discuss some problems encountered and possible solutions for future work.
description: 23 pages, 9 figures, 6 tables
Phenotypic characterization of Ghanaian P. falciparum clinical isolates reveals a homogenous parasite population.
Creators: name: Thiam, Laty G
name: Nyarko, Prince B
name: Ansah, Felix
name: Niang, Makhtar
name: Awandare, Gordon A
name: Aniweh, Yaw
Publisher: name: The Francis Crick Institute
Year: 2022
Subjects: Infectious Disease

description: Background: Erythrocyte invasion by P. falciparum involves functionally overlapping interactions between the parasite's ligands and the erythrocyte surface receptors. While some P. falciparum isolates necessarily engage the sialic acid (SA) moieties of the erythrocytes during the invasion, others use ligands whose binding is independent of SA for successful invasion. Deciphering the major pathway used by P. falciparum clinical isolates represent a key step toward developing an efficient blood stage malaria vaccine. Methods: We collected a total of 156 malaria-infected samples from Ghanaian children aged 2 to 14 years and used a two-color flow cytometry-based invasion assay to assess the invasion phenotype diversity of Ghanaian P. falciparum clinical isolates. Anti-human CR1 antibodies were used to determine the relative contribution of the PfRh4-CR1 interaction in the parasites invasion phenotype and RT-qPCR was used to assess the expression levels of key invasion-related ligands. Results: Our findings show no clear association between demographic or clinical data and existing reports on the malaria transmission intensity. The complete invasion data obtained for 156 isolates, showed the predominance of SA-independent pathways in Ghanaian clinical isolates. Isolates from Hohoe and Navrongo had the highest diversity in invasion profile. Our data also confirmed that the PfRh4-CR1 mediated alternative pathway is important in Ghanaian clinical isolates. Furthermore, the transcript levels of ten invasion-related genes obtained in the study showed little variations in gene expression profiles within and between parasite populations across sites. Conclusion: Our data suggest a low level of phenotypic diversity in Ghanaian clinical isolates across areas of varying endemicity and further highlight its importance in the quest for new intervention strategies, such as the investigation of blood-stage vaccine targets, particularly those targeting specific pathways and able to trigger the stimulation of broadly neutralizing invasion antibodies.
Desenvolvimento de modelo para predição de cotações de ação baseada em análise de sentimentos de tweets
Creators: name: Akita, Mario Mitsuo
name: da Silva, Everton Josue
Publisher: name: arXiv
Year: 2023
Subjects: subject: Statistical Finance (q-fin.ST)
subject: Machine Learning (cs.LG)
subject: FOS: Economics and business
subject: FOS: Computer and information sciences

description: Training machine learning models for predicting stock market share prices is an active area of research since the automatization of trading such papers was available in real time. While most of the work in this field of research is done by training Neural networks based on past prices of stock shares, in this work, we use iFeel 2.0 platform to extract 19 sentiment features from posts obtained from microblog platform Twitter that mention the company Petrobras. Then, we used those features to train XBoot models to predict future stock prices for the referred company. Later, we simulated the trading of Petrobras' shares based on the model's outputs and determined the gain of R$88,82 (net) in a 250-day period when compared to a 100 random models' average performance.
description: in Portuguese language, Presented at: 1o Semin\'ario de Ci\^encia de Dados do IFSP. Campinas: 2023
title:   MILK THISTLE SUPPLEMENTATION AND EXERCISE TO INFLUENCE BILIRUBIN AND BODY WEIGHT OUTCOMES
Creators: name: Matutina, Don Arthur
Publisher: name: University of Kentucky Libraries
Year: 2023
Subjects: classificationCode: 4.5
subject: FOS: Other agricultural sciences

description: Background: Traditional obesity treatment is ineffective as rates are still on the rise, thus necessitating novel treatments. Plasma bilirubin, once thought as only a clinical marker of liver disease, is now considered an important hormone, correlated with better outcomes within certain metabolic disease states such as cardiovascular disease and diabetes. This is largely due to bilirubin’s role in promoting fatty acid oxidation via its interaction with PPARα and its antioxidant capacities to reduce lipid peroxidation. Possible methods of mildly increasing plasma bilirubin may provide a novel obesity treatment. Objective: To evaluate if Silmarin supplementation via milk thistle, exercise, or a combination of the two can increase plasma bilirubin. This study also tested the hypothesis that increases in plasma bilirubin are correlated with decreases in body fat mass. Methods: Male and female adults with obesity (BMI > 30.0, N=19) were split into 4 groups and participated in a 12-week intervention. Participants were assigned either Milk Thistle or a Placebo supplement condition, and either an exercise (participate in a 12-week aerobic exercise program) or sedentary control (engage in no structured exercise) condition. Fasting blood samples were collected and body composition assessments (BodPod) were performed pre and post intervention. Results: Trends were observed for the Silmarin supplementation + Exercise group for increasing plasma bilirubin and decreasing fat mass. Increased levels of bilirubin were moderately correlated with decreasing fat mass. Conclusions: In this small sample size, there are trends demonstrating ways to increase bilirubin through supplementation and that increasing bilirubin promotes decreases in body fat mass.
description: © 2023 Don Arthur Matutina
Final Dissemination,  Communication and Outreach plan
Creators: name: EUROPEAN BUSINESS AND INNOVATION CENTRE NETWORK (EBN)
Publisher: name: Zenodo
Year: 2024

description: This document aims to provide the final version of the Dissemination, Communication and Outreach Plan (DCOP) initially delivered in March 2021. This plan has set the operational framework for the EiA project and EiA Center’s dissemination strategy and defined the frame of reference for EiA partners for effective dissemination, promotion and communication of the project’s activities and results.
title: ÐÐ°ÑÐ¾Ð²ÑÐµ ÐºÐ¾ÑÐ»Ñ. Ð§. 4, Ð Ð°ÑÑÐµÑ Ð¿Ð¾Ð·Ð¾Ð½Ð½Ð¾Ð³Ð¾ ÑÐµÐ¿Ð»Ð¾Ð¾Ð±Ð¼ÐµÐ½Ð° Ð² ÑÐ¾Ð¿Ð¾ÑÐ½ÑÑ ÐºÐ°Ð¼ÐµÑÐ°Ñ
title: ÑÑÐµÐ±Ð½Ð¾Ðµ Ð¿Ð¾ÑÐ¾Ð±Ð¸Ðµ
titleType: Subtitle
Creators: name: Ð¨ÐµÑÑÐ°ÐºÐ¾Ð², Ð¡ÑÐ°Ð½Ð¸ÑÐ»Ð°Ð²
name: ÐÑÐ¼ÐµÐ´Ð¾Ð², ÐÐ¶Ð°Ð²Ð°Ð´
name: Ð¢ÑÐ¸Ð½ÑÐµÐ½ÐºÐ¾, ÐÐ»ÐµÐºÑÐµÐ¹
Publisher: name: ÐÐ·Ð´-Ð²Ð¾ Ð¡ÐÐ±ÐÐÐ£
Year: 2002
Subjects: ÐÐ¾ÑÐµÐ»ÑÐ½ÑÐµ ÑÐ¾Ð¿ÐºÐ¸

description: ÐÐ¾ÑÐ¾Ð±Ð¸Ðµ ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²ÑÐµÑ Ð³Ð¾ÑÑÐ´Ð°ÑÑÑÐ²ÐµÐ½Ð½Ð¾Ð¼Ñ Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°ÑÐµÐ»ÑÐ½Ð¾Ð¼Ñ ÑÑÐ°Ð½Ð´Ð°ÑÑÑ Ð´Ð¸ÑÑÐ¸Ð¿Ð»Ð¸Ð½ Â«ÐÐ°ÑÐ¾Ð²ÑÐµ ÐºÐ¾ÑÐ»ÑÂ» Ð¸ Â«Ð­Ð½ÐµÑÐ³ÐµÑÐ¸ÑÐµÑÐºÐ¸Ðµ Ð¼Ð°ÑÐ¸Ð½Ñ Ð¸ ÑÑÑÐ°Ð½Ð¾Ð²ÐºÐ¸Â» Ð½Ð°Ð¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ð¹ Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ¾Ð¹ Ð¿Ð¾Ð´Ð³Ð¾ÑÐ¾Ð²ÐºÐ¸ 552700 Â«Ð­Ð½ÐµÑÐ³Ð¾Ð¼Ð°ÑÐ¸Ð½Ð¾ÑÑÑÐ¾ÐµÐ½Ð¸ÐµÂ» Ð¸ 550900 Â«Ð¢ÐµÐ¿Ð»Ð¾ÑÐ½ÐµÑÐ³ÐµÑÐ¸ÐºÐ°Â». Ð Ð°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ð° Ð¼ÐµÑÐ¾Ð´Ð¸ÐºÐ° ÑÐ°ÑÑÐµÑÐ° Ð¿Ð¾Ð·Ð¾Ð½Ð½Ð¾Ð³Ð¾ ÑÐµÐ¿Ð»Ð¾Ð¾Ð±Ð¼ÐµÐ½Ð° Ð² ÑÐ¾Ð¿Ð¾ÑÐ½ÑÑ ÐºÐ°Ð¼ÐµÑÐ°Ñ; Ð¿ÑÐ¸Ð²ÐµÐ´ÐµÐ½Ñ Ð½ÐµÐ¾Ð±ÑÐ¾Ð´Ð¸Ð¼ÑÐµ Ð³ÑÐ°ÑÐ¸ÐºÐ¸, ÑÐ°Ð±Ð»Ð¸ÑÑ, ÑÐ°ÑÑÐµÑÐ½ÑÐµ ÑÐ¾Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ñ. ÐÐ¾ÑÐ¾Ð±Ð¸Ðµ ÑÐ²Ð»ÑÐµÑÑÑ ÑÐµÑÐ²ÐµÑÑÐ¾Ð¹ ÑÐ°ÑÑÑÑ Ð¸Ð·Ð´Ð°Ð½Ð¸Ñ Â«ÐÐÐ ÐÐÐ«Ð ÐÐÐ¢ÐÐ«Â» (Ð§. 1. ÐÐ¾Ð¼Ð¿Ð¾Ð½Ð¾Ð²ÐºÐ° Ð¸ ÑÐµÐ¿Ð»Ð¾Ð²Ð¾Ð¹ Ð±Ð°Ð»Ð°Ð½Ñ ÐºÐ¾ÑÐ»Ð°; Ð§. 2. Ð Ð°ÑÑÐµÑ ÑÐ¾Ð¿Ð¾Ðº Ð¿Ð°ÑÐ¾Ð²ÑÑ ÐºÐ¾ÑÐ»Ð¾Ð²; Ð§. 3. ÐÐ¾Ð½ÑÑÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ ÑÐ¾Ð¿Ð¾ÑÐ½ÑÑ ÐºÐ°Ð¼ÐµÑ). ÐÑÐµÐ´Ð½Ð°Ð·Ð½Ð°ÑÐµÐ½Ð¾ Ð´Ð»Ñ Ð²ÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð¸Ñ ÐºÑÑÑÐ¾Ð²ÑÑ Ð¸ Ð´Ð¸Ð¿Ð»Ð¾Ð¼Ð½ÑÑ Ð¿ÑÐ¾ÐµÐºÑÐ¾Ð² (ÑÐ°Ð±Ð¾Ñ), Ð´Ð»Ñ Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¸Ð¸ ÑÐ°Ð¼Ð¾ÑÑÐ¾ÑÑÐµÐ»ÑÐ½Ð¾Ð¹ Ð¸ Ð½Ð°ÑÑÐ½Ð¾-Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°ÑÐµÐ»ÑÑÐºÐ¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ ÑÑÑÐ´ÐµÐ½ÑÐ¾Ð², Ð° ÑÐ°ÐºÐ¶Ðµ Ð´Ð»Ñ Ð½Ð°Ð¿Ð¸ÑÐ°Ð½Ð¸Ñ ÑÐ°Ð·Ð´ÐµÐ»Ð¾Ð² Ð²ÑÐ¿ÑÑÐºÐ½ÑÑ ÑÐ°Ð±Ð¾Ñ Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ¾Ð² Ð¸ Ð¼Ð°Ð³Ð¸ÑÑÐµÑÑÐºÐ¸Ñ Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ð¹.
description: ÐÐµÑÐ°ÑÐ°ÐµÑÑÑ Ð¿Ð¾ ÑÐµÑÐµÐ½Ð¸Ñ ÑÐµÐ´Ð°ÐºÑÐ¸Ð¾Ð½Ð½Ð¾-Ð¸Ð·Ð´Ð°ÑÐµÐ»ÑÑÐºÐ¾Ð³Ð¾ ÑÐ¾Ð²ÐµÑÐ° Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¾Ð³Ð¾ Ð³Ð¾ÑÑÐ´Ð°ÑÑÑÐ²ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑÐ°.
Probing SARS-CoV-2-positive plasma to identify potential factors correlating with mild COVID-19 in Ghana, West Africa.
Creators: name: Tapela, Kesego
name: Oyawoye, Fatima O
name: Olwal, Charles Ochieng'
name: Opurum, Precious C
name: Amponsah, Jones Amo
name: Segbedzi, Kekeli Aku Lumor
name: Tetteh, Becky
name: Kumi-Ansah, Frederick
name: Mutungi, Joe K
name: Obodai, Evangeline
name: Amoako, Emmanuella
name: Agyemang, Seth
name: Ndam, Nicaise Tuikue
name: Ampofo, William Kwabena
name: Rayner, Julian C
name: Awandare, Gordon A
name: Paemka, Lily
name: Bediako, Yaw
name: Quashie, Peter Kojo
Publisher: name: The Francis Crick Institute
Year: 2022
Subjects: Infectious Disease

description: BACKGROUND: West Africa has recorded a relatively higher proportion of asymptomatic coronavirus disease 2019 (COVID-19) cases than the rest of the world, and West Africa-specific host factors could play a role in this discrepancy. Here, we assessed the association between COVID-19 severity among Ghanaians with their immune profiles and ABO blood groups. METHODS: Plasma samples were obtained from Ghanaians PCR-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive individuals. The participants were categorized into symptomatic and asymptomatic cases. Cytokine profiling and antibody quantification were performed using Luminex™ multiplex assay whereas antigen-driven agglutination assay was used to assess the ABO blood groups. Immune profile levels between symptomatic and asymptomatic groups were compared using the two-tailed Mann-Whitney U test. Multiple comparisons of cytokine levels among and between days were tested using Kruskal-Wallis with Dunn's post hoc test. Correlations within ABO blood grouping (O's and non-O's) and between cytokines were determined using Spearman correlations. Logistic regression analysis was performed to assess the association of various cytokines with asymptomatic phenotype. RESULTS: There was a trend linking blood group O to reduced disease severity, but this association was not statistically significant. Generally, symptomatic patients displayed significantly (p < 0.05) higher cytokine levels compared to asymptomatic cases with exception of Eotaxin, which was positively associated with asymptomatic cases. There were also significant (p < 0.05) associations between other immune markers (IL-6, IL-8 and IL-1Ra) and disease severity. Cytokines' clustering patterns differ between symptomatic and asymptomatic cases. We observed a steady decrease in the concentration of most cytokines over time, while anti-SARS-CoV-2 antibody levels were stable for at least a month, regardless of the COVID-19 status. CONCLUSIONS: The findings suggest that genetic background and pre-existing immune response patterns may in part shape the nature of the symptomatic response against COVID-19 in a West African population. This study offers clear directions to be explored further in larger studies.