cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Revocation of Citizenship in Canada: A Criminological Reading of a Tension Between Rights and Obligations in Conceptions of Citizenship
Creators: name: Nazemi, Shahriar
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2019
Subjects: subject: Citizenship revocation
subject: Criminology
subject: FOS: Law
subject: Welfare state
subject: Liberal model
subject: Bill C-24

description: This research explores the political debates surrounding changes in the law regulating citizenship revocation in Canada and how they reflect the tensions in the meaning of citizenship for dual national citizens. Borrowing from citizenship studies and critical criminology, the main argument in this thesis is that Bill C-24 seems to be an attempt on part of the Conservative Party to recalibrate the meaning of citizenship from a more liberal understanding (based on civic rights) to one that is more republican (based on civic duty). This research also demonstrates how this recalibration in the conception of citizenship from a more liberal notion to a more republican one parallels the shift in crime control policies of the state that were geared more toward prioritizing the welfare and equality of all citizens under the law in the 1960s-70s to ones that are presently oriented toward punishment, control and management of “dangerous groups”. The scholarly literature suggests that the modern conception of citizenship tends to draw from the republican and liberal traditions that are complementary but are also in tension, and the recent political discussions surrounding citizenship involves arguing for the best balance between rights and responsibilities of citizens. The analysis of the parliamentary debates surrounding Bill C-24 reveals that, in light of Canada’s current political landscape that is heavily influenced by penal-populist notions of punishing the offender populations and making “responsibilized” citizens, the pendulum of citizenship is generally being tilted toward the republican model (based on restoration of civic duties of citizens to the state and their fellow citizens) more so than the liberal model (based on preserving the welfare, liberty and equality of all citizens under the law).
Evolution equation for soft physics at high energy
Creators: name: Brogueira, P.
name: de Deus, J. Dias
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Based on the non-linear logistic equation we study, in a qualitative and semi-quantitative way, the evolution with energy and saturation of the elastic differential cross-section in $pp(\bar{p}p)$ collisions at high energy. Geometrical scaling occurs at the black disk limit, and scaling develops first for small values of the scaling variable $|t|σ_{tot.}$. Our prediction for $d σ/ \ d t$ at LHC, with two zeros and a minimum at large $|t|$ differs, as far as we know, from all existing ones.
description: Latex, 7 pages, 3 figures
Sexualität als Thema von pädagogischen Fachkräften. Schlaglichter aus englischsprachigen Fachdiskursen
Creators: name: List, Inga Marie
Publisher: name: Zenodo
Year: 2018
Subjects: sexuality
social work
social workers
pedagogy

description: In diesem Vortrag, der beim Bundeskongress Soziale Arbeit 2018 in Bielefeld gehalten wurde, werden internationale Forschungsergebnisse zum Umgang mit Sexualität in pädagogischen Kontexten vorgestellt. Der Hauptschwerpunkt liegt dabei auf den Erfahrungen der pädagogischen Fachkräfte und wie ihr Verständnis von Sexualität in den untersuchten englischsprachigen Fachzeitschriften dargestellt wird. Daraus ergeben sich wichtige Anknüpüfungspunkte für Forschung und Praxis der Pädagogik und Sozialen Arbeit in Deutschland, auf die in diesem Vortrag ebenfalls eingegangen wird.

Die verwandte Literatur wurde im Rahmen eines Monitoring des englischsprachigen Forschungsstandes zu sexueller Gewalt in pädagogischen Kontexten gesammelt und aufbereitet (siehe: Forschungsnetzwerk gegen sexualisierte Gewalt).
description: Diese Arbeit wurde finanziert durch das Bundesministerium für Bildung und Forschung als Teil des Forschungsprojekts ProPEM - "Profilbildung, Praxistransfer, Ethik und Monitoring in der Förderlinie 'Sexuelle Gewalt in pädagogischen Kontexten'".
УПРАВЛЕНИЕ ПРЕДПРИНИМАТЕЛЬСКИМИ РИСКАМИ ДЛЯ ОБЕСПЕЧЕНИЯ ЭКОНОМИЧЕСКОЙ БЕЗОПАСНОСТИ КОМПАНИИ
Creators: name: ПТИЦА К.А.
name: КЛИМИНА К.В.
name: ИЗВАРИНА Н.Ю.
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: ЭКОНОМИЧЕСКАЯ БЕЗОПАСНОСТЬ
БЕЗОПАСНОСТЬ БИЗНЕСА
РИСК МЕНЕДЖМЕНТ
СИСТЕМА ЗАЩИТЫ БИЗНЕСА
УПРАВЛЕНИЕ РИСКОМ
СИСТЕМА КОРПОРАТИВНОЙ БЕЗОПАСНОСТИ
ECONOMIC SECURITY
BUSINESS SECURITY
RISK MANAGEMENT
BUSINESS PROTECTION SYSTEM
CORPORATE SECURITY SYSTEM

description: В статье представлено обоснование использования системы риск-менеджмента для удовлетворения информационных интересов собственников, менеджеров различного уровня и других пользователей информации. Предложен комплексный подход по управлению рисками, состоящий из четырех этапов. Реализация стратегии защиты от рисков, представляющих угрозу стабильному функционированию компании, позволяет своевременно принимать корректирующие управленческие решения, что повышает эффективность системы экономической безопасности бизнеса.
The Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events
Creators: name: Dadwal, Nirdosh
name: Mix, Charlie
name: Reinhold, Annegret
name: Witte, Amelie
name: Freund, Christian
name: Schraven, Burkhart
name: Kliche, Stefanie
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: T-cell activation
subject: integrin signaling
subject: ADAP/SKAP1/2
subject: T cells
subject: adaptive immunology
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: T cells are the key players of the adaptive immune response. They coordinate the activation of other immune cells and kill malignant and virus-infected cells. For full activation T cells require at least two signals. Signal 1 is induced after recognition of MHC/peptide complexes presented on antigen presenting cells (APCs) by the clonotypic TCR (T-cell receptor)/CD3 complex whereas Signal 2 is mediated via the co-stimulatory receptor CD28, which binds to CD80/CD86 molecules that are present on APCs. These signaling events control the activation, proliferation and differentiation of T cells. In addition, triggering of the TCR/CD3 complex induces the activation of the integrin LFA-1 (leukocyte function associated antigen 1) leading to increased ligand binding (affinity regulation) and LFA-1 clustering (avidity regulation). This process is termed “inside-out signaling”. Subsequently, ligand bound LFA-1 transmits a signal into the T cells (“outside-in signaling”) which enhances T-cell interaction with APCs (adhesion), T-cell activation and T-cell proliferation. After triggering of signal transducing receptors, adapter proteins organize the proper processing of membrane proximal and intracellular signals as well as the activation of downstream effector molecules. Adapter proteins are molecules that lack enzymatic or transcriptional activity and are composed of protein-protein and protein-lipid interacting domains/motifs. They organize and assemble macromolecular complexes (signalosomes) in space and time. Here, we review recent findings regarding three cytosolic adapter proteins, ADAP (Adhesion and Degranulation-promoting Adapter Protein), SKAP1 and SKAP2 (Src Kinase Associated Protein 1 and 2) with respect to their role in TCR/CD3-mediated activation, proliferation and integrin regulation.
Tunneling Spin Injection into Single Layer Graphene (Supplementary Information)
Creators: name: Han, Wei
name: Pi, K.
name: McCreary, K. M.
name: Li, Yan
name: Wong, Jared J. I.
name: Swartz, A. G.
name: Kawakami, R. K.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We achieve tunneling spin injection from Co into single layer graphene (SLG) using TiO2 seeded MgO barriers. A non-local magnetoresistance (ΔRNL) of 130 Ω is observed at room temperature, which is the largest value observed in any material. Investigating ΔRNL vs. SLG conductivity from the transparent to the tunneling contact regimes demonstrates the contrasting behaviors predicted by the drift-diffusion theory of spin transport. Furthermore, tunnel barriers reduce the contact-induced spin relaxation and are therefore important for future investigations of spin relaxation in graphene.
description: 5 pages, 2 figures. To appear in Physics Review Letters
ПРОБЛЕМНЫЕ АСПЕКТЫ УЧЁТА И КОНТРОЛЯ ДЕБИТОРСКОЙ И КРЕДИТОРСКОЙ ЗАДОЛЖЕННОСТИ
Creators: name: КАЗНОВА М.И.
name: КИСЕЛЕВА К.С.
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: РАСЧЁТЫ
ДЕБИТОРСКАЯ ЗАДОЛЖЕННОСТЬ
ПРЕДПРИЯТИЕ
КРЕДИТОРСКАЯ ЗАДОЛЖЕННОСТЬ
ОБЯЗАТЕЛЬСТВА
КОНТРАГЕНТЫ
ФИНАНСОВАЯ УСТОЙЧИВОСТЬ
ПРОГНОЗИРОВАНИЕ
БАНКРОТСТВО
SETTLEMENTS
ACCOUNTS RECEIVABLE
ENTERPRISE
ACCOUNTS PAYABLE
LIABILITIES
COUNTERPARTIES
FINANCIAL STABILITY
FORECASTING
BANKRUPTCY

description: Для совершенствования процесса управления кредиторской и дебиторской задолженностью хозяйствующего субъекта необходимо формирование оптимальной системы их мониторинга, анализа и учета. Постоянный и систематичный контроль, детализация данной системы повышают эффективность использования вышеперечисленных объектов в деятельности предприятия. Важность исследования заключается в постановке задач для формирования оптимальной и рациональной аналитической базы по расчетам с контрагентами при учете кредиторской и дебиторской задолженности предприятия.
Calderón-Zygmund operators related to Jacobi expansions
Creators: name: Nowak, Adam
name: Sjögren, Peter
Publisher: name: arXiv
Year: 2010
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics
subject: 42C05 (Primary) 42C10 (Secondary)

description: We study several fundamental operators in harmonic analysis related to Jacobi expansions, including Riesz transforms, imaginary powers of the Jacobi operator, the Jacobi-Poisson semigroup maximal operator and Littlewood-Paley-Stein square functions. We show that these are (vector-valued) Calderón-Zygmund operators in the sense of the associated space of homogeneous type, and hence their mapping properties follow from the general theory. Our proofs rely on an explicit formula for the Jacobi-Poisson kernel, which we derive from a product formula for Jacobi polynomials.
description: 27 pages
Microglia Function on Precursor Cells in the Adult Hippocampus and Their Responsiveness to Serotonin Signaling
Creators: name: Turkin, Andrei
name: Tuchina, Oksana
name: Klempin, Friederike
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: microglia
subject: serotonin
subject: hippocampus
subject: BDNF
subject: fluoxetine
subject: neuroinflammation
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Microglia are the resident immune cells of the adult brain that become activated in response to pathogen- or damage-associated stimuli. The acute inflammatory response to injury, stress, or infection comprises the release of cytokines and phagocytosis of damaged cells. Accumulating evidence indicates chronic microglia-mediated inflammation in diseases of the central nervous system, most notably neurodegenerative disorders, that is associated with disease progression. To understand microglia function in pathology, knowledge of microglia communication with their surroundings during normal state and the release of neurotrophins and growth factors in order to maintain homeostasis of neural circuits is of importance. Recent evidence shows that microglia interact with serotonin, the neurotransmitter crucially involved in adult neurogenesis, and known for its role in antidepressant action. In this chapter, we illustrate how microglia contribute to neuroplasticity of the hippocampus and interact with local factors, e.g., BDNF, and external stimuli that promote neurogenesis. We summarize the recent findings on the role of various receptors in microglia-mediated neurotransmission and particularly focus on microglia's response to serotonin signaling. We review microglia function in neuroinflammation and neurodegeneration and discuss their novel role in antidepressant mechanisms. This synopsis sheds light on microglia in healthy brain and pathology that involves serotonin and may be a potential therapeutic model by which microglia play a crucial role in the maintenance of mood.
ВЛИЯНИЕ САНКЦИЙ НА ЭКОНОМИКУ РОССИИ
Creators: name: АХРИЕВА М.М.-Б.
name: КИТИЕВА М.И.
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: САНКЦИИ
НАЦИОНАЛЬНАЯ ЭКОНОМИКА
ЭКОНОМИЧЕСКИЕ САНКЦИИ
ВВП
РОССИЙСКАЯ ЭКОНОМИКА
SANCTIONS
NATIONAL ECONOMY
ECONOMIC SANCTIONS
GDP
RUSSIAN ECONOMY

description: Все более значима в наши дни внешняя экономическая политика. Каждая страна стремится к установлению геополитической власти, которая может повлиять на экономическое благосостояние. Одним из наиболее эффективных инструментов воздействия на политику и экономику государства санкции. В данной статье мы рассмотрим влияние санкций на экономику России.
The Presbyterians.
Creators: name: Rumble, Leslie
Publisher: name: University of Notre Dame
Year: 2023

description:
 John Calvin -- John Knox -- Developments in Scotland -- Position in England -- American churches -- Presbyterian teachings -- The Bible -- The church -- The ministry -- The creeds -- The sacraments -- Organization -- Worship -- Membership -- Tendencies -- The real problem -- The original church -- The original ministry -- Conclusion.
Development and Validation of a Robust Ferroptosis-Related Prognostic Signature in Lung Adenocarcinoma
Creators: name: Zhang, Anran
name: Yang, Jinpo
name: Ma, Chao
name: Li, Feng
name: Luo, Huan
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: biomarkers
subject: tumor immunity
subject: prognosis
subject: risk score
subject: gene signature
subject: ferroptosis
subject: lung adenocarcinoma
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer. Ferroptosis is a newly recognized process of cell death, which is different from other forms of cell death in morphology, biochemistry, and genetics, and has played a vital role in cancer biology. This study aimed to identify a ferroptosis-related gene signature associated with LUAD prognosis. Methods Dataset TCGA-LUAD which came from the TCGA portal was taken as the training cohort. GSE72094 and GSE68465 from the GEO database were treated as validation cohorts. Two hundred fifty-nine ferroptosis-related genes were retrieved from the FerrDb database. In the training cohort, Kaplan-Meier and univariate Cox analyses were conducted for preliminary screening of ferroptosis-related genes with potential prognostic capacity. These genes then entered into the LASSO Cox regression model, constructing a gene signature. The latter was then evaluated in the training and validation cohorts via Kaplan-Meier, Cox, and ROC analyses. In addition, the correlations between risk score and autophagy were examined by Pearson correlation coefficient. The analyses of GSEA and immune infiltrating were performed for better studying the function annotation of the gene signature and the character of each kind of immune cells played in the tumor microenvironment. Results A 15-gene signature was found from the training cohort and validated by Kaplan-Meier and Cox regression analyses, revealing its independent prognosis value in LUAD. Moreover, the ROC analysis was conducted, confirming a strong predictive ability that this signature owned for LUAD prognosis. One hundred fifty-one of 222 (68.01%) autophagy-related genes were discovered significantly correlated with risk scores. Analyses of GSEA and immune infiltration exhibited in detail the specific pathways that associate with the 15-gene signature and identified the crucial roles of resting mast cells and resting dendritic cells owned in the prognosis of the 15-gene signature. Conclusion In this present study, a novel ferroptosis-related 15-gene signature (RELA, ACSL3, YWHAE, EIF2S1, CISD1, DDIT4, RRM2, PANX1, TLR4, ARNTL, LPIN1, HERPUD1, NCOA4, PEBP1, and GLS2) was built. It could accurately predict the prognosis of LUAD and was related to resting mast cells and resting dendritic cells, which provide potential for the personalized outcome prediction and the development of new therapies in LUAD population.
ТЕКУЩЕЕ СОСТОЯНИЕ СЕЛЬСКОХОЗЯЙСТВЕННЫХ ОРГАНИЗАЦИЙ КРАСНОДАРСКОГО КРАЯ И ТЕНДЕНЦИИ ИХ РАЗВИТИЯ
Creators: name: СТОРЧАКОВА В.Г.
name: КОНОВАЛОВ Н.А.
name: КЛИМОВСКИХ Н.В.
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: КРАСНОДАРСКИЙ КРАЙ
АГРАРНЫЕ ПРЕДПРИЯТИЯ
СЕЛЬСКОЕ ХОЗЯЙСТВО
ЭФФЕКТИВНОСТЬ АГРАРНОГО СЕКТОРА
KRASNODAR TERRITORY
AGRICULTURAL ENTERPRISES
AGRICULTURE
THE EFFECTIVENESS OF THE AGRICULTURAL SECTOR

description: В статье анализируются показатели развития агропромышленного комплекса Краснодарского края, выявляются ключевые проблемы и основные направления повышения эффективности функционирования агропромышленного комплекса региона. Был проведен анализ статистических данных по индексу производства и урожайности сельскохозяйственных культур Краснодарского края. Также было выявлено, что в долгосрочной перспективе повысится конкурентоспособность аграрного сектора Краснодарского края на российском и международном рынке.
Excited states and precision results for nucleon charges and form factors
Creators: name: Gupta, Rajan
name: Bhattacharya, Tanmoy
name: Cirigliano, Vincenzo
name: Hoferichter, Martin
name: Jang, Yong-Chull
name: Joo, Balint
name: Mereghetti, Emanuele
name: Mondal, Santanu
name: Park, Sungwoo
name: Winter, Frank
name: Yoon, Boram
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The exponentially falling signal-to-noise ratio in all nucleon correlation functions, and the presence of towers of multihadron excited states with relatively small mass gaps makes extraction of matrix elements of various operators within the ground state nucleon challenging. Theoretically, the allowed positive parity states with the smallest mass gaps are the $N(\bm p)π(-\bm p)$, $N(\bm 0)π(\bm 0)π(\bm 0)$, $N(\bm p)π(\bm 0)$, $N(\bm 0)π(\bm p),\ \ldots$, states. A priori, the contribution of these states arises at one loop in chiral perturbation theory ($χ$PT), however, in many cases the contributions are enhanced. In this talk, I will review four such cases: the correlation functions from which the axial form factors, electric and magnetic form factors, the $Θ$-term contribution to neutron electric dipole moment (nEDM), and the pion-nucleon sigma term are extracted. Including appropriate multihadron states in the analysis can lead to significantly different results compared to standard analyses with the mass gaps taken from fits to 2-point functions. The $χ$PT case for $N π$ states is the most clear in the axial/pseudoscalar form factors which need to satisfy the PCAC relation between them. Our analyses, supported by $χ$PT, suggests similarly large effects in the calculations of the $Θ$-term and the pion-nucleon sigma term that have significant phenomenological implications.
description: 9 pages 6 figures. Contribution to the 38th International Symposium on Lattice Field Theory, LATTICE2021 26th-30th July, 2021
ПРОБЛЕМЫ ОСУЩЕСТВЛЕНИЯ ЭКСПОРТНОГО КОНТРОЛЯ В РОССИЙСКОЙ ФЕДЕРАЦИИ
Creators: name: ШАФИЕВА А.Р.
name: КОЗЛОВА А.С.
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: ЭКСПОРТНЫЙ КОНТРОЛЬ
ОРУЖИЕ МАССОВОГО ПОРАЖЕНИЯ
УЧАСТНИКИ ВНЕШНЕЭКОНОМИЧЕСКОЙ ДЕЯТЕЛЬНОСТИ
ТОВАРЫ ДВОЙНОГО НАЗНАЧЕНИЯ
EXPORT CONTROL
WEAPONS OF MASS DESTRUCTION
PARTICIPANTS IN FOREIGN ECONOMIC ACTIVITY
DUAL-USE GOODS

description: В настоящее время сохраняются случаи нарушений российскими участниками внешнеэкономической деятельности обязательных требований в сфере экспортного контроля, что подтверждает необходимость совершенствования работы по профилактике нарушений обязательных требований и выполнения контрольных мероприятий в целях будущего недопущения нарушений национальных интересов и международных обязательств. В статье обобщена деятельность Федеральной службы по техническому и экспортному контролю России при выполнении своих основных функций, проанализированы основные проблемы экспортного контроля, осуществляемого в Российской Федерации, представлены основные направления развития экспортного контроля в Российской Федерации.
Effects of Humor in Health Communication: Experimental Evidence for Video Sequences Aiming to Increase the Willingness to Donate Organs
Creators: name: Baumeister, Rebecca
name: Fischer, Florian
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: humor
subject: medical cabaret
subject: organ donation
subject: organ transplantation
subject: testimonial
subject: entertainment education
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Humor has been proven to provide support when dealing with fear-related aspects of life. Therefore, it might be a useful communication strategy for addressing the need for donated organs. We conducted an experimental study among University students in Germany (n = 236) aged about 25 years (M = 24.60, SD = 5.86) investigating the effects of four video sequences related to organ donation on the willingness to donate organs. Based on random allocation, each study participant received one video sequence. The video sequences were presented by either a prominent or non-prominent speaker and included either humorous or neutrally framed information related to organ donation. An online survey was conducted before and after the intervention. A follow-up to investigate long-term effects was conducted 4-6 weeks later. Overall, the four interventions led to high proportions of self-reported willingness to think about organ donation and talk about it with relatives and friends subsequent to the respective intervention. Appraisals beneficial to organ donation improved significantly only in the non-humorous interventions. It seems to be of little relevance whether the humorous message was communicated by a prominent or non-prominent person. However, future investigations should focus on sample populations with lower education, because they are less likely to possess an organ donor card and more likely to have lower levels of positive attitudes toward organ donation and may, therefore, show different results regarding the effectiveness of humorous interventions.
ОСНОВНЫЕ ОТЛИЧИТЕЛЬНЫЕ ОСОБЕННОСТИ СПОРТИВНОГО МАРКЕТИНГА
Creators: name: КОЛЕСИНА К.
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: СПОРТИВНЫЙ МАРКЕТИНГ
ЦЕЛЕВАЯ АУДИТОРИЯ
СПОРТИВНЫЙ ПРОДУКТ
МАРКЕТИНГОВЫЕ ИССЛЕДОВАНИЯ
СПОРТ
SPORT MARKETING
TARGET AUDIENCE
SPORTS PRODUCT
MARKETING RESEARCH
SPORTS

description: В статье автором раскрываются основные вопросы связанные с особенностями функционирования спортивного маркетинга. Проанализированы аспекты и отдельные отличительные особенности спортивного маркетинга от базового понятия маркетинг. Приведены различные примеры из сферы спорта. Также автором отмечено, что спортивный маркетинг заключается в выстраивании особых отношений со средствами массовой информации. Все перечисленные особенности должны учитывать в своей деятельности спортивные маркетологи.
Induction Chemotherapy for Primarily Unresectable Locally Advanced Pancreatic Adenocarcinoma—Who Will Benefit from a Secondary Resection?
Creators: name: Rosumeck, Nathalie
name: Timmermann, Lea
name: Klein, Fritz
name: Bahra, Marcus
name: Stintzig, Sebastian
name: Malinka, Thomas
name: Pelzer, Uwe
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: pancreatic cancer
subject: neoadjuvant therapy
subject: induction therapy
subject: secondary resection
subject: pancreatic surgery
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background and Objectives: An increasing number of patients (pts) with locally advanced pancreatic cancer (LAPC) are treated with an intensive neoadjuvant therapy to obtain a secondary curative resection. Only a certain number of patients benefit from this intention. The aim of this investigation was to identify prognostic factors which may predict a benefit for secondary resection. Materials and Methods: Survival time and clinicopathological data of pts with pancreatic cancer were prospective and consecutively collected in our Comprehensive Cancer Center Database. For this investigation, we screened for pts with primarily unresectable pancreatic cancer who underwent a secondary resection after receiving induction therapy in the time between March 2017 and May 2019. Results: 40 pts had a sufficient database to carry out a reliable analysis. The carbohydrate-antigen 19-9 (CA 19-9) level of the pts treated with induction therapy decreased by 44.7% from 4358.3 U/mL to 138.5 U/mL (p = 0.001). The local cancer extension was significantly reduced (p < 0.001), and the Eastern Cooperative Oncology Group (ECOG) performance status was lowered (p = 0.03). The median overall survival (mOS) was 20 months (95% CI: 17.2-22.9). Pts who showed a normal CA 19-9 level (<37 U/mL) at diagnosis and after neoadjuvant therapy or had a Body Mass Index (BMI) below 25 kg/m(2) after chemotherapy had a significant prolonged overall survival (29 vs. 19 months, p = 0.02; 26 vs. 18 months, p = 0.04; 15 vs. 24 months, p = 0.01). Pts who still presented elevated CA 19-9 levels >400 U/mL after induction therapy did not profit from a secondary resection (24 vs. 7 months, p < 0.001). Nodal negativity as well as the performance of an adjuvant therapy lead to better mOS (25 vs. 15 months, p = 0.003; 10 vs. 25 months, p < 0.001). Conclusion: The pts in our investigation had different benefits from the multimodal treatment. We identified the CA 19-9 level at time of diagnosis and after neoadjuvant therapy as well as the preoperative BMI as predictive factors for overall survival. Furthermore, diagnostics of presurgical nodal status should gain more importance as nodal negativity is associated with better outcome.
УПРАВЛЕНИЕ ВРЕМЕНЕМ КАК ЭФФЕКТИВНОЕ СРЕДСТВО МЕНЕДЖМЕНТА
Creators: name: АВРАМЕНКО М.А.
name: КОНДРАШОВА Н.Г.
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: ТАЙМ-МЕНЕДЖМЕНТ
УПРАВЛЕНИЕ
ИНФОРМАЦИЯ
СПОСОБЫ УСВОЕНИЯ
ПРИНЦИПЫ ПРИМЕНЕНИЯ
TIME-MANAGEMENT
MANAGEMENT
INFORMATION
METHODS OF ASSIMILATION
PRINCIPLES OF APPLYING

description: В связи с тем, что менеджмент предполагает эффективное использование всех и самых разнообразных ресурсов для повышения производительности человеческого труда в настоящей статье рассмотрим один из них - физическое время. Эффективное управление временем основано на том, что сотрудник должен сознательно оценивать себя при выполнении конкретных видов деятельности с использованием тест-контроля за оценкой времени. Предложены способы и методы эффективного усвоения информации. Определены принципы применения тайм менеджмента в профессиональной деятельности.
NAUTILOS D11.2 - Open Access Instrumentation Roadmap
Creators: name: Lemos, Catarina
name: Magalhães, Raquel
name: Costa, Daniel
Publisher: name: Zenodo
Year: 2023

description: This deliverable is the outcome of the work performed in Task 11.2 – “Instrumentation Roadmap. Scalability, replicability and transferability study” until M24. It presents NAUTILOS proposal for OIAR (open access instrumentation roadmap) development with a multi-step data collection methodology so that a set of reliable and updated marine instrumentation data, from industrial companies, universities and research centres, might be collected and shared in order to foster scalability, replicability and transferability of those European products, including NAUTILOS sensors and samplers. A final version of the roadmap will be released as a tool for exploitation in Power BI and included in NAUTILOS Exploitation Strategy to be delivered in M48, which will include validated data, obtained directly from oceanography stakeholders. The roadmap builds on top of H2020 AtlantOS project and includes information from the Ocean of Tomorrow Projects (FP7) that includes Common Sense and NeXOS projects as well as information from NAUTILOS, following the general community recommendations on FAIR data. NAUTILOS OIAR will include the name of the sensor/instrument, the application area or type of technology, maturity level (TRL) and information about its ongoing or planned commercialization, as other information (e.g. Owner institution). This deliverable also includes an update about the exploitation strategy, namely highlights future exercises to perform with all sensor developers (SWOT and BMC) to start exploring possible approaches to market with each of NAUTILOS sensor developer.
ПРИЧИНЫ И МЕТОДЫ УСТРАНЕНИЯ ОБРАЗОВАНИЯ НЕЛИКВИДНЫХ ТОВАРНЫХ ЗАПАСОВ В РОЗНИЧНОЙ ТОРГОВЛЕ
Creators: name: КОНЫЧЕВА А.В.
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: НЕЛИКВИДНЫЕ ТОВАРНЫЕ ЗАПАСЫ
РОЗНИЧНАЯ ТОРГОВЛЯ
ОБОРАЧИВАЕМОСТЬ
ЛИКВИДНОСТЬ
ЗАКУПКИ
ПРОДАЖИ
ПОТРЕБИТЕЛЬСКИЕ ТОВАРЫ
СПРОС
ILLIQUID INVENTORY
RETAIL
TURNOVER
LIQUIDITY
PURCHASES
SALES
CONSUMER GOODS
DEMAND

description: В статье поднимаются вопросы, связанные с управлением запасов в розничной торговле. В частности, рассматривается тема образования неликвидных товарных запасов и методы их устранения. Автор дает определение понятию «неликвидность», указывает почему необходимо бороться с неликвидными товарами и как определять их на практике. Отмечается на что стоит обращать внимание при работе с неликвидными товарными запасами. Для анализа ассортимента предложены два показателя: рентабельность инвестиций в товарные запасы и критический срок хранения.
Wave function multifractality and dephasing at metal-insulator and quantum Hall transitions
Creators: name: Burmistrov, I. S.
name: Bera, S.
name: Evers, F.
name: Gornyi, I. V.
name: Mirlin, A. D.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: We analyze the critical behavior of the dephasing rate induced by short-range electron-electron interaction near an Anderson transition of metal-insulator or quantum Hall type. The corresponding exponent characterizes the scaling of the transition width with temperature. Assuming no spin degeneracy, the critical behavior can be studied by performing the scaling analysis in the vicinity of the non-interacting fixed point, since the latter is stable with respect to the interaction. We combine an analytical treatment (that includes the identification of operators responsible for dephasing in the formalism of the non-linear sigma-model and the corresponding renormalization-group analysis in $2+ε$ dimensions) with numerical simulations on the Chalker-Coddington network model of the quantum Hall transition. Finally, we discuss the current understanding of the Coulomb interaction case and the available experimental data.
description: 33 pages, 7 figures, elsart style
Angiostatin Inhibits Endothelial and Melanoma Cellular Invasion by Blocking Matrix-Enhanced Plasminogen Activation
Creators: name: Soff, Gerald
name: Enghild, J J
name: Bafetti, L M
name: Stack, Sharon
name: Gately, S
Publisher: name: University of Notre Dame
Year: 2023

description: Angiostatin,a kringle-containing fragment of plasminogen,is a potent inhibitor of angiogenesis. The mechanism(s) responsible for the anti-angiogenic properties of angiostatin are unknown. We now report that human angiostatin blocks plasmin(ogen)-enhanced in vitro invasion of tissue plasminogen activator (t-PA)-producing endothelial and melanoma cells. Kinetic analyses demonstrated that angiostatin functions as a non-competitive inhibitor of extracellular-matrix (ECM)-enhanced,t-PA-catalysed plasminogen activation,with a Ki of 0.9+/-0.03 microM. This mechanism suggests that t-PA has a binding site for the inhibitor angiostatin,as well as for its substrate plasminogen that,when occupied,prevents ternary complex formation between t-PA,plasminogen and matrix protein. Direct binding experiments confirmed that angiostatin bound to t-PA with an apparent Kd [Kd(app)] of 6.7+/-0.7 nM,but did not bind with high affinity to ECM proteins. Together,these data suggest that angiostatin in the cellular micro-environment can inhibit matrix-enhanced plasminogen activation,resulting in reduced invasive activity,and suggest a biochemical mechanism whereby angiostatin-mediated regulation of plasmin formation could influence cellular migration and invasion.
ОЦЕНКА ЭКОНОМИЧЕСКОЙ БЕЗОПАСНОСТИ НЕКОММЕРЧЕСКОЙ ОРГАНИЗАЦИИ
Creators: name: САМАРИН Н.О.
name: КУЗНЕЦОВА О.А.
name: КОСТИНА О.В.
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: ЭКОНОМИЧЕСКАЯ БЕЗОПАСНОСТЬ
НЕКОММЕРЧЕСКАЯ ОРГАНИЗАЦИЯ
ИНДИКАТОР
ФИНАНСОВЫЙ ПОТЕНЦИАЛ
ПРОИЗВОДСТВЕННЫЙ ПОТЕНЦИАЛ
СОЦИАЛЬНО-ПРАВОВОЙ ПОТЕНЦИАЛ
КАДРОВЫЙ ПОТЕНЦИАЛ
ECONOMIC SECURITY
NON-PROFIT ORGANIZATION
INDICATOR
FINANCIAL POTENTIAL
PRODUCTION POTENTIAL
SOCIAL AND LEGAL POTENTIAL
HUMAN RESOURCES POTENTIAL

description: Статья посвящена рассмотрению методологии оценки уровня экономической безопасности некоммерческой организации. Развернуто рассматривается система, комплексно отражающая основные риски и угрозы деятельности НКО. Приведена формула расчета интегрального показателя экономической безопасности некоммерческой организации, осуществлено практическое применение и его графическая интерпретация. В результате проведенного исследования была осуществлена математическая оценка уровня экономической безопасности и определен уровень каждого потенциала.
Collateral Damage: Reuse in the Arts and the New Role of Quotation Provisions in Countries with Free Use Provisions After the ECJ’s Pelham, Funke Medien and Spiegel Online Judgments
Creators: name: Hui, Alan
name: Döhl, Frédéric
Publisher: name: Freie Universität Berlin
Year: 2021
Subjects: subject: Copyright
subject: Quotation
subject: Reuse
subject: Free use
subject: EU
subject: 300 Sozialwissenschaften::340 Recht::340 Recht

description: This article examines the impact of the European Court of Justice’s Pelham decision (C-476/17) on reuse, including appropriation art, borrowing and plagiarism in the arts, especially in music. Insofar, the focus lies on countries that have operated before with broad free use provisions. Specifically, we consider the extent to which EU law permits quotation provisions to fill the gap left by free use limitations, which have been curtailed by the Pelham decision. As we explain, Pelham creates a more restrictive approach to certain unlicensed use of copyright materials in new works of artistic expression, including music appropriation. We present our research in four sections. First, we compare existing national free use and quotation provisions in four states subject to EU law regarding their respective wiggle room for unlicensed yet lawful reuse in the arts. Second, we explore how the ECJ’s interpretation of the InfoSoc quotation exception, particularly in the Pelham, Funke Medien and Spiegel Online judgments, minimises the leeway for reuse in the arts provided by these national quotation provisions, in comparison to free use provisions. (Information Society Directive, 2001/29/EC.) Third, we address possible objections to our position and explain why we believe the consequences of the ECJ decisions cannot be bypassed. (Copyright in the Digital Single Market Directive, (EU) 2019/790.) Finally, in the conclusion, we explore the consequences, including the need for legislative reform.
Swarms with canonical active Brownian motion
Creators: name: Gluck, Alexander
name: Huffel, Helmuth
name: Ilijic, Sasa
Publisher: name: arXiv
Year: 2010
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We present a swarm model of Brownian particles with harmonic interactions, where the individuals undergo canonical active Brownian motion, i.e. each Brownian particle can convert internal energy to mechanical energy of motion. We assume the existence of a single global internal energy of the system. Numerical simulations show amorphous swarming behavior as well as static configurations. Analytic understanding of the system is provided by studying stability properties of equilibria.
description: 5 pages, 3 figures
ГЕНЕЗИС РАЗВИТИЯ ЗДРАВООХРАНЕНИЯ В РОССИИ
Creators: name: КУЗНЕЦОВА В.А.
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: СИСТЕМА ЗДРАВООХРАНЕНИЯ
ЭТАПЫ
РОССИЯ
ИСТОРИЯ РАЗВИТИЯ
МЕДИЦИНА
HEALTH SYSTEM
STAGES
RUSSIA
HISTORY OF DEVELOPMENT
MEDICINE

description: В статье рассмотрены основные этапы развития в сфере здравоохранения Российской Федерации. Здравоохранение, прежде всего, как социальная система, является одним из главных инструментов государственной политики по сохранению и укреплению национального здоровья всех граждан, формированию успешного трудового потенциала и благополучия страны в целом. Актуальность статьи заключается в том, что перманентные изменения в государственной системе здравоохранения для достижения положительных эффектов не возможны без анализа накопленного опыта прошлых десятилетий, используемых как в России, так и за рубежом.
Tata Cara Penyelesaian Perkara Pidana
Creators: name: Ardiyanto, Fahmi
name: Yovita Ari Mangesti
Publisher: name: Zenodo
Year: 2022
Subjects: Penyelesaian Perkara pidana, Hukum Acara Pidana, Hukum Pidana

description: booklet penyelesaian Perkara pidana berisi terkait dengan alur/proses penyelesaian perkara pidana secara singkat dan padat yang bisa di pahami dengan mudah oleh para pembacanya
ИНСТАГРАМ КАК ИСТОЧНИК ЗАРАБОТКА И РАЗВИТИЯ ПРЕДПРИНИМАТЕЛЬСКИХ СПОСОБНОСТЕЙ
Creators: name: АНИКЕЕВА А.С.
name: КОЛЕСНИКОВА К.М.
name: КУЗЬМИНА Е.В.
Publisher: name: Экономика и бизнес: теория и практика
Year: 2020
Subjects: ИСТОЧНИК ЗАРАБОТКА
ПРЕДПРИНИМАТЕЛЬСТВО
ИНСТАГРАМ
БЛОГЕРСТВО
РЕКЛАМА
SOURCE OF EARNINGS
ENTREPRENEURSHIP
INSTAGRAM
BLOGGING
ADVERTISING

description: В настоящее время интернет получает интенсивное развитие и по большей части является торговой площадкой. Одним из масштабных и посещаемых сервисов, получивших признание в 2010 году, считается Инстаграм. Данная социальная сеть - безграничный кладезь для потребителя, продавца и других участников торговых отношений. В статье рассматривается социальная сеть Инстаграм, с положительных и отрицательных сторон, как источник заработка и развития предпринимательских способностей.
Thalamic but Not Subthalamic Neuromodulation Simplifies Word Use in Spontaneous Language
Creators: name: Tiedt, Hannes Ole
name: Ehlen, Felicitas
name: Wyrobnik, Michelle
name: Klostermann, Fabian
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: thalamus
subject: language
subject: deep brain stimulation
subject: lexical frequency
subject: frequency effect
subject: lexical access
subject: spontaneous language
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Several investigations have shown language impairments following electrode implantation surgery for Deep Brain Stimulation (DBS) in movement disorders. The impact of the actual stimulation, however, differs between DBS targets with further deterioration in formal language tests induced by thalamic DBS in contrast to subtle improvement observed in subthalamic DBS. Here, we studied speech samples from interviews with participants treated with DBS of the thalamic ventral intermediate nucleus (VIM) for essential tremor (ET), or the subthalamic nucleus (STN) for Parkinson's disease (PD), and healthy volunteers (each n = 13). We analyzed word frequency and the use of open and closed class words. Active DBS increased word frequency in case of VIM, but not STN stimulation. Further, relative to controls, both DBS groups produced fewer open class words. Whereas VIM DBS further decreased the proportion of open class words, it was increased by STN DBS. Thus, VIM DBS favors the use of relatively common words in spontaneous language, compatible with the idea of lexical simplification under thalamic stimulation. The absence or even partial reversal of these effects in patients receiving STN DBS is of interest with respect to biolinguistic concepts suggesting dichotomous thalamic vs. basal ganglia roles in language processing.
Occupational Disorders, Daily Workload, and Fitness Levels Among Fitness and Swimming Instructors
Creators: name: Merati, Giampiero
name: Bonato, Matteo
name: Agnello, Luca
name: Grevers, Dorothée
name: Gunga, Hanns-Christian
name: Mendt, Stefan
name: Maggioni, Martina Anna
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: occupational disorder
subject: cardiopulmonary assessment
subject: rate of perceived exertion
subject: musculoskeletal disorders
subject: heart rate monitoring
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Few data have been published on occupational disorders among sports instructors, especially regarding those who are expected to continuously practice while teaching. As the number of sports instructors increases, new specific information about their possible injuries, daily workload, and fitness levels is needed. The aim of this study was to assess occupational disorders, cardiorespiratory fitness, and daily workload of fitness (FI) and swimming instructors (SI). An online survey addressing occupational disorders was conducted among 435 instructors (256 FI and 179 SI). In one subgroup (57 FI and 42 SI), cardiorespiratory fitness levels were evaluated using maximal oxygen consumption ((V)over dotO(2max)) as an indicator. Daily workload was assessed by monitoring the heart rate and perception of exertion (using the Borg scale). Of the two groups, FI exhibited a higher 2-year prevalence of musculoskeletal injuries and SI experienced more upper respiratory tract infections. (V)over dotO(2max) ranged from 47.0 to 51.9 ml.kg(-1).min(-1) and was similar for both FI and SI. Regarding the daily workload, female SI had significantly higher mean heart rate and mean heart rate to maximal heart rate ratio compared to female FI, but no significant differences between male FI and SI were found. No significant differences were observed between the perceived exertion of FI and SI. Preventive strategies for the reduction of occupational disorders in FI and SI are needed.
Design and fabrication of electrospun nanofiber catalyst support for polymer electrolyte membrane fuel cells
Creators: name: Chan, Sophia Shuk Kwan
Publisher: name: University of British Columbia
Year: 2018

description: Progress in fuel cell technology is impeded by the lack of understanding of the fundamental design characteristics necessary to improve the performance. Current catalyst design suffers from challenges related to platinum utilization, triple phase boundary, mass transport, and durability. Little improvement has been made in novel fuel cell catalyst designs, in particularly, there is a lack of microstructural optimization. As a result, a relationship between the catalyst layer microstructure and fuel cell performance has not been established. This study addresses this crucial problem by finding connections between controlled microstructure and key fuel cell performance factors. Specifically, electrospun nanofibers as a catalyst support offered a number of controllable structural parameters including: porosity, fiber diameter, fiber alignment, and layer thickness. The material and structural properties of carbonized nanofibers were optimized by factorial design for incorporation into a fuel cell membrane electrode assembly. Validation of the structural and material properties of the carbon nanofiber catalyst support was analyzed by electrochemical, physiochemical, and microscopy methods. Carbon nanofiber were integrated into membrane electrode assemblies and tested in situ to develop structure-property-performance relationships pertaining to Pt loading, ionomer loading, substrate electrical properties, and fiber mesh geometry. Performance was characterized by cyclic voltammetry, polarization, and electrochemical impedance spectroscopy. Results confirm not only ionomer thickness and loading, but more importantly ionomer distribution influenced polarization losses. 150 µg cm-² and 250 µg cm-² Pt loading achieved the same maximum current density, suggesting reduced loading maintained satisfactory Pt utilization, decreasing the amount of Pt. Although the influence of fiber orientation on fuel cell performance was inconclusive, fiber electrical conductivity, ionomer thickness, and Pt distribution were found to be essential for the development of efficient low cost catalyst layers. In conclusion, carbon nanofiber catalyst support revealed enhanced surface area, durability, Pt utilization, and efficiencies due to the porous mesh structure.
Optical bistability in nonlinear system with two loops of feedback
Creators: name: Miroshnichenko, George P.
name: Trifanov, Alexander I.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences
subject: 81V10, 81V80

description: A model of nonlinear optical system surrounded by two loops of feedback is investigated. The cell with the vapor of rubidium - type atoms is taken in the capacity of nonlinear element. Two modes of near-resonant electromagnetic field interacting with the cell are involved in the feedback. Two-dimensional optical bistability domain in location of input field intensities is obtained and dependence of its form and magnitude from the system parameters (photon detunings, feedback factor etc.) is investigated. "Input - output" relations corresponding to different trajectories in the bistability domain are obtained. Cross-hysteresis is studied.
description: 7 pages, 14 figures, conference ICONO/LAT 2010, Kazan, Russia
title: Selective gene expression profiling contributes to a better understanding of the molecular pathways underlying the histological changes observed after RHMVL
Creators: name: Arlt, Janine
name: Vlaic, Sebastian
name: Feuer, Ronny
name: Thomas, Maria
name: Settmacher, Utz
name: Dahmen, Uta
name: Dirsch, Olaf
Publisher: name: Universität Stuttgart
Year: 2022
Subjects: subject: 620

description: Background. In previous studies, five vasoactive drugs were investigated for their effect on the recovery process after extended liver resection without observing relevant improvements. We hypothesized that an analysis of gene expression could help to identify potentially druggable pathways and could support the selection of promising drug candidates. Methods. Liver samples obtained from rats after combined 70% partial hepatectomy and right median hepatic vein ligation ( n  = 6/group) sacrificed at 0 h, 24 h, 48 h, and 7days were selected for this study. Liver samples were collected from differentially perfused regions of the median lobe (obstruction-zone, border-zone, normal-zone). Gene expression profiling of marker genes regulating hepatic hemodynamics, vascular remodeling, and liver regeneration was performed with microfluidic chips. We used 3 technical replicates from each sample. Raw data were normalized using LEMming and differentially expressed genes were identified using LIMMA. Results. The strongest differences were found in obstruction-zone at 24 h and 48 h postoperatively compared to all other groups. mRNA expression of marker genes from hepatic hemodynamics pathways (iNOS,Ptgs2,Edn1) was most upregulated. Conclusion. These upregulated genes suggest a strong vasoconstrictive effect promoting arterial hypoperfusion in the obstruction-zone. Reducing iNOS expression using selective iNOS inhibitors seems to be a promising approach to promote vasodilation and liver regeneration.