Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
Creators: name: Menden, Michael P.
name: Wang, Dennis
name: Mason, Mike J.
name: Szalai, Bence
name: Bulusu, Krishna C.
name: Guan, Yuanfang
name: Yu, Thomas
name: Kang, Jaewoo
name: Jeon, Minji
name: Wolfinger, Russ
name: Nguyen, Tin
name: Zaslavskiy, Mikhail
name: Jang, In Sock
name: Ghazoui, Zara
name: Ahsen, Mehmet Eren
name: Vogel, Robert
name: Neto, Elias Chaibub
name: Norman, Thea
name: Tang, Eric K. Y.
name: Garnett, Mathew J.
name: Veroli, Giovanni Y. Di
name: Fawell, Stephen
name: Stolovitzky, Gustavo
name: Guinney, Justin
name: Dry, Jonathan R.
name: Saez-Rodriguez, Julio
name: Abante, Jordi
name: Abecassis, Barbara Schmitz
name: Aben, Nanne
name: Aghamirzaie, Delasa
name: Aittokallio, Tero
name: Akhtari, Farida S.
name: Al-Lazikani, Bissan
name: Alam, Tanvir
name: Allam, Amin
name: Allen, Chad
name: De Almeida, Mariana Pelicano
name: Altarawy, Doaa
name: Alves, Vinicius
name: Amadoz, Alicia
name: Anchang, Benedict
name: Antolin, Albert A.
name: Ash, Jeremy R.
name: Aznar, Victoria Romeo
name: Ba-Alawi, Wail
name: Bagheri, Moeen
name: Bajic, Vladimir
name: Ball, Gordon
name: Ballester, Pedro J.
name: Baptista, Delora
name: Bare, Christopher
name: Bateson, Mathilde
name: Bender, Andreas
name: Bertrand, Denis
name: Wijayawardena, Bhagya
name: Boroevich, Keith A.
name: Bosdriesz, Evert
name: Bougouffa, Salim
name: Bounova, Gergana
name: Brouwer, Thomas
name: Bryant, Barbara
name: Calaza, Manuel
name: Calderone, Alberto
name: Calza, Stefano
name: Capuzzi, Stephen
name: Carbonell-Caballero, Jose
name: Carlin, Daniel
name: Carter, Hannah
name: Castagnoli, Luisa
name: Celebi, Remzi
name: Cesareni, Gianni
name: Chang, Hyeokyoon
name: Chen, Guocai
name: Chen, Haoran
name: Chen, Huiyuan
name: Cheng, Lijun
name: Chernomoretz, Ariel
name: Chicco, Davide
name: Cho, Kwang-Hyun
name: Cho, Sunghwan
name: Choi, Daeseon
name: Choi, Jaejoon
name: Choi, Kwanghun
name: Choi, Minsoo
name: Cock, Martine De
name: Coker, Elizabeth
name: Cortes-Ciriano, Isidro
name: Cserzö, Miklós
name: Cubuk, Cankut
name: Curtis, Christina
name: Daele, Dries Van
name: Dang, Cuong C.
name: Dijkstra, Tjeerd
name: Dopazo, Joaquin
name: Draghici, Sorin
name: Drosou, Anastasios
name: Dumontier, Michel
name: Ehrhart, Friederike
name: Eid, Fatma-Elzahraa
name: ElHefnawi, Mahmoud
name: Elmarakeby, Haitham
name: Van Engelen, Bo
name: Engin, Hatice Billur
name: De Esch, Iwan
name: Evelo, Chris
name: Falcao, Andre O.
name: Farag, Sherif
name: Fernandez-Lozano, Carlos
name: Fisch, Kathleen
name: Flobak, Asmund
name: Fornari, Chiara
name: Foroushani, Amir B. K.
name: Fotso, Donatien Chedom
name: Fourches, Denis
name: Friend, Stephen
name: Frigessi, Arnoldo
name: Gao, Feng
name: Gao, Xiaoting
name: Gerold, Jeffrey M.
name: Gestraud, Pierre
name: Ghosh, Samik
name: Gillberg, Jussi
name: Godoy-Lorite, Antonia
name: Godynyuk, Lizzy
name: Godzik, Adam
name: Goldenberg, Anna
name: Gomez-Cabrero, David
name: Gonen, Mehmet
name: De Graaf, Chris
name: Gray, Harry
name: Grechkin, Maxim
name: Guimera, Roger
name: Guney, Emre
name: Haibe-Kains, Benjamin
name: Han, Younghyun
name: Hase, Takeshi
name: He, Di
name: He, Liye
name: Heath, Lenwood S.
name: Hellton, Kristoffer H.
name: Helmer-Citterich, Manuela
name: Hidalgo, Marta R.
name: Hidru, Daniel
name: Hill, Steven M.
name: Hochreiter, Sepp
name: Hong, Seungpyo
name: Hovig, Eivind
name: Hsueh, Ya-Chih
name: Hu, Zhiyuan
name: Huang, Justin K
name: Huang, R. Stephanie
name: Hunyady, László
name: Hwang, Jinseub
name: Hwang, Tae Hyun
name: Hwang, Woochang
name: Hwang, Yongdeuk
name: Isayev, Olexandr
name: Don’t Walk, Oliver Bear
name: Jack, John
name: Jahandideh, Samad
name: Ji, Jiadong
name: Jo, Yousang
name: Kamola, Piotr J.
name: Kanev, Georgi K.
name: Karacosta, Loukia
name: Karimi, Mostafa
name: Kaski, Samuel
name: Kazanov, Marat
name: Khamis, Abdullah M
name: Khan, Suleiman Ali
name: Kiani, Narsis A.
name: Kim, Allen
name: Kim, Jinhan
name: Kim, Juntae
name: Kim, Kiseong
name: Kim, Kyung
name: Kim, Sunkyu
name: Kim, Yongsoo
name: Kim, Yunseong
name: Kirk, Paul D. W.
name: Kitano, Hiroaki
name: Klambauer, Gunter
name: Knowles, David
name: Ko, Melissa
name: Kohn-Luque, Alvaro
name: Kooistra, Albert J.
name: Kuenemann, Melaine A.
name: Kuiper, Martin
name: Kurz, Christoph
name: Kwon, Mijin
name: Van Laarhoven, Twan
name: Laegreid, Astrid
name: Lederer, Simone
name: Lee, Heewon
name: Lee, Jeon
name: Lee, Yun Woo
name: Lepp_aho, Eemeli
name: Lewis, Richard
name: Li, Jing
name: Li, Lang
name: Liley, James
name: Lim, Weng Khong
name: Lin, Chieh
name: Liu, Yiyi
name: Lopez, Yosvany
name: Low, Joshua
name: Lysenko, Artem
name: Machado, Daniel
name: Madhukar, Neel
name: Maeyer, Dries De
name: Malpartida, Ana Belen
name: Mamitsuka, Hiroshi
name: Marabita, Francesco
name: Marchal, Kathleen
name: Marttinen, Pekka
name: Mason, Daniel
name: Mazaheri, Alireza
name: Mehmood, Arfa
name: Mehreen, Ali
name: Michaut, Magali
name: Miller, Ryan A.
name: Mitsopoulos, Costas
name: Modos, Dezso
name: Moerbeke, Marijke Van
name: Moo, Keagan
name: Motsinger-Reif, Alison
name: Movva, Rajiv
name: Muraru, Sebastian
name: Muratov, Eugene
name: Mushthofa, Mushthofa
name: Nagarajan, Niranjan
name: Nakken, Sigve
name: Nath, Aritro
name: Neuvial, Pierre
name: Newton, Richard
name: Ning, Zheng
name: Niz, Carlos De
name: Oliva, Baldo
name: Olsen, Catharina
name: Palmeri, Antonio
name: Panesar, Bhawan
name: Papadopoulos, Stavros
name: Park, Jaesub
name: Park, Seonyeong
name: Park, Sungjoon
name: Pawitan, Yudi
name: Peluso, Daniele
name: Pendyala, Sriram
name: Peng, Jian
name: Perfetto, Livia
name: Pirro, Stefano
name: Plevritis, Sylvia
name: Politi, Regina
name: Poon, Hoifung
name: Porta, Eduard
name: Prellner, Isak
name: Preuer, Kristina
name: Pujana, Miguel Angel
name: Ramnarine, Ricardo
name: Reid, John E.
name: Reyal, Fabien
name: Richardson, Sylvia
name: Ricketts, Camir
name: Rieswijk, Linda
name: Rocha, Miguel
name: Rodriguez-Gonzalvez, Carmen
name: Roell, Kyle
name: Rotroff, Daniel
name: De Ruiter, Julian R.
name: Rukawa, Ploy
name: Sadacca, Benjamin
name: Safikhani, Zhaleh
name: Safitri, Fita
name: Sales-Pardo, Marta
name: Sauer, Sebastian
name: Schlichting, Moritz
name: Seoane, Jose A.
name: Serra, Jordi
name: Shang, Ming-Mei
name: Sharma, Alok
name: Sharma, Hari
name: Shen, Yang
name: Shiga, Motoki
name: Shin, Moonshik
name: Shkedy, Ziv
name: Shopsowitz, Kevin
name: Sinai, Sam
name: Skola, Dylan
name: Smirnov, Petr
name: Soerensen, Izel Fourie
name: Soerensen, Peter
name: Song, Je-Hoon
name: Song, Sang Ok
name: Soufan, Othman
name: Spitzmueller, Andreas
name: Steipe, Boris
name: Suphavilai, Chayaporn
name: Tamayo, Sergio Pulido
name: Tamborero, David
name: Tang, Jing
name: Tanoli, Zia-Ur-Rehman
name: Tarres-Deulofeu, Marc
name: Tegner, Jesper
name: Thommesen, Liv
name: Tonekaboni, Seyed Ali Madani
name: Tran, Hong
name: Troyer, Ewoud De
name: Truong, Amy
name: Tsunoda, Tatsuhiko
name: Turu, Gábor
name: Tzeng, Guang-Yo
name: Verbeke, Lieven
name: Videla, Santiago
name: Vis, Daniel
name: Voronkov, Andrey
name: Votis, Konstantinos
name: Wang, Ashley
name: Wang, Hong-Qiang Horace
name: Wang, Po-Wei
name: Wang, Sheng
name: Wang, Wei
name: Wang, Xiaochen
name: Wang, Xin
name: Wennerberg, Krister
name: Wernisch, Lorenz
name: Wessels, Lodewyk
name: Van Westen, Gerard J. P.
name: Westerman, Bart A.
name: White, Simon Richard
name: Willighagen, Egon
name: Wurdinger, Tom
name: Xie, Lei
name: Xie, Shuilian
name: Xu, Hua
name: Yadav, Bhagwan
name: Yau, Christopher
name: Yeerna, Huwate
name: Yin, Jia Wei
name: Yu, Michael
name: Yu, MinHwan
name: Yun, So Jeong
name: Zakharov, Alexey
name: Zamichos, Alexandros
name: Zanin, Massimiliano
name: Zeng, Li
name: Zenil, Hector
name: Zhang, Frederick
name: Zhang, Pengyue
name: Zhang, Wei
name: Zhao, Hongyu
name: Zhao, Lan
name: Zheng, Wenjin
name: Zoufir, Azedine
name: Zucknick, Manuela
Publisher: name: Apollo - University of Cambridge Repository
Year: 2019
Subjects: Article
/631/114/1305
/631/114/2415
/631/154/1435/2163
/631/553
/692/4028/67
/49
/13
/49/23
/49/39
/45
/49/98
article

description: Abstract: The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca’s large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for &gt;60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contrasting to synergy when combined with other PI3K-pathway inhibitors in PIK3CA mutant cells.