cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Quantum breaking of ergodicity in semi-classical charge transfer dynamics
Creators: name: Goychuk, Igor
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Does electron transfer (ET) kinetics within a single-electron trajectory description always coincide with the ensemble description? This fundamental question of ergodic behavior is scrutinized within a very basic semi-classical curve-crossing problem of quantum Landau-Zener tunneling between two electronic states with overdamped classical reaction coordinate. It is shown that in the limit of non-adiabatic electron transfer (weak tunneling) well-described by the Marcus-Levich-Dogonadze (MLD) rate the answer is yes. However, in the limit of the so-called solvent-controlled adiabatic electron transfer a profound breaking of ergodicity occurs. The ensemble survival probability remains nearly exponential with the inverse rate given by the sum of the adiabatic curve crossing (Kramers) time and inverse MLD rate. However, near to adiabatic regime, the single-electron survival probability is clearly non-exponential but possesses an exponential tail which agrees well with the ensemble description. Paradoxically, the mean transfer time in this classical on the ensemble level regime is well described by the inverse of nonadiabatic quantum tunneling rate on a single particle level.
Vortex Dynamics-Mediated Low-Field Magnetization Switching in an Exchange-Coupled System
Creators: name: Zhou, Weinan
name: Seki, Takeshi
name: Arai, Hiroko
name: Imamura, Hiroshi
name: Takanashi, Koki
Publisher: name: arXiv
Year: 2016
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: A magnetic vortex has attracted significant attention since it is a topologically stable magnetic structure in a soft magnetic nanodisk. Many studies have been devoted to understanding the nature of magnetic vortex in isolated systems. Here we show a new aspect of a magnetic vortex the dynamics of which strongly affects the magnetic structures of environment. We exploit a nanodot of an exchange-coupled bilayer with a soft magnetic Ni81Fe19 (permalloy; Py) having a magnetic vortex and a perpendicularly magnetized L10-FePt exhibiting a large switching field (Hsw). The vortex dynamics with azimuthal spin waves makes the excess energy accumulate in the Py, which triggers the reversed-domain nucleation in the L10-FePt at a low magnetic field. Our results shed light on the non-local mechanism of a reversed-domain nucleation, and provide with a route for efficient Hsw reduction that is needed for ultralow-power spintronic devices.
description: 26 pages, 5 figures, Supplementary Information
Smectic Layering: Landau theory for a complex-tensor order parameter
Creators: name: Paget, Jack
name: Alberti, Una
name: Mazza, Marco G.
name: Archer, Andrew J.
name: Shendruk, Tyler N.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: Composed of microscopic layers that stack along one direction while maintaining fluid-like positional disorder within layers, smectics are excellent systems for exploring topology, defects and geometric memory in complex confining geometries. However, the coexistence of crystalline-like characteristics in one direction and fluid-like disorder within layers makes lamellar liquid crystals notoriously difficult to model - especially in the presence of defects and large distortions. Nematic properties of smectics can be comprehensively described by the Q-tensor but to capture the features of the smectic layering alone, we develop a phenomenological Landau theory for a complex-tensor order parameter E, which is capable of describing the local degree of lamellar ordering, layer displacement, and orientation of the layers. This theory can account for both parallel and perpendicular elastic contributions. In addition to resolving the potential ambiguities inherent to complex scalar order parameter models, this model reduces to previous employed models of simple smectics, and opens new possibilities for numerical studies on smectics possessing many defects, within complex geometries and under extreme confinement.
description: 23 pages, 3 figures
Additional file 2 of Support for relatives in the intensive care unit: lessons from a cross-sectional multicentre cohort study during the COVID-19 pandemic
Creators: name: Renckens, Sophie C.
name: Pasman, H. Roeline
name: Klop, Hanna T.
name: du Perron, Chantal
name: van Zuylen, Lia
name: Steegers, Monique A. H.
name: ten Tusscher, Birkitt L.
name: Abbink, Floor C. H.
name: de Ruijter, Wouter
name: Vloet, Lilian C. M.
name: Koster, Stephanie C. E.
name: Onwuteaka-Philipsen, Bregje D.
Publisher: name: figshare
Year: 2023
Subjects: subject: Biophysics
subject: Medicine
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 2. Differences in experiences and satisfaction for different periods between ICU admission and questionnaire completion.
UM4: Unified Multilingual Multiple Teacher-Student Model for Zero-Resource Neural Machine Translation
Creators: name: Yang, Jian
name: Yin, Yuwei
name: Ma, Shuming
name: Zhang, Dongdong
name: Wu, Shuangzhi
name: Guo, Hongcheng
name: Li, Zhoujun
name: Wei, Furu
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computation and Language (cs.CL)
subject: Artificial Intelligence (cs.AI)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Most translation tasks among languages belong to the zero-resource translation problem where parallel corpora are unavailable. Multilingual neural machine translation (MNMT) enables one-pass translation using shared semantic space for all languages compared to the two-pass pivot translation but often underperforms the pivot-based method. In this paper, we propose a novel method, named as Unified Multilingual Multiple teacher-student Model for NMT (UM4). Our method unifies source-teacher, target-teacher, and pivot-teacher models to guide the student model for the zero-resource translation. The source teacher and target teacher force the student to learn the direct source to target translation by the distilled knowledge on both source and target sides. The monolingual corpus is further leveraged by the pivot-teacher model to enhance the student model. Experimental results demonstrate that our model of 72 directions significantly outperforms previous methods on the WMT benchmark.
description: 7 pages, 5 figures, IJCAI-ECAI 2022
Characterisation of the role of four-and-a-half LIM protein 1 (FHL1) in skeletal muscle differentiation and mature striated muscle function
Creators: name: McGrath., Meagan Jane
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
The flux dynamics behavior of the two competing high temperature superconducting phases in underdoped LaCuO4.06
Creators: name: Di Gioacchino, D.
name: Puri, A.
name: Marcelli, A.
name: Poccia, N.
name: Ricci, A.
name: Bianconi, A.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: In complex transition metal oxides (TMO) an arrested electronic phase separation (PS) appears by tuning the system near a Lifshitz transition in multiband Hubbard models. The PS in La2CuO4+y near insulator to metal transition (IMT) is made of short range Charge Density Wave (CDW) order inhomogeneity coexisting with quenched lattice disorder. While at high doping y=0.1 percolation gives a single superconducting phase, near the IMT at y=0.06 two coexisting superconducting phases appear: the first one with a critical temperature Tc1=16 K and the second one with Tc2=29K. It is known that the two superconducting phases are characterized by two different space geometry because of two different spatial distributions of both CDW order and dopants self-organization. Here we show that these two phases show different flux dynamic regimes using alternating current (AC) multi-harmonic susceptibility experiments. This is a unique technique capable to investigate multi-phase superconductors and characterize their transport properties in a percolative scenario. Results point out that the low critical temperature phase is well described by a bulk-like flux pinning with a 2D geometry while the phase with higher critical temperature shows a barrier pinning mechanism providing direct evidence of two different superconducting vortex dynamics in different complex geometrical spaces.
description: 15 pages, 3 figures in Phys. Chem. Chem. Phys. (2016)
Significance of a one-degree Celsius increase in global temperature
Creators: name: Gagnon, Jean-Sebastien
Publisher: name: arXiv
Year: 2022
Subjects: subject: Atmospheric and Oceanic Physics (physics.ao-ph)
subject: Physics Education (physics.ed-ph)
subject: Popular Physics (physics.pop-ph)
subject: FOS: Physical sciences

description: The Intergovernmental Panel on Climate Change reports indicate that the global mean temperature is about one-degree Celsius higher than pre-industrial levels, that this increase is anthropogenic, and that there is a causal relationship between this higher temperature and an increase in frequency and magnitude of extreme weather events. This causal relationship seems at odds with common sense, and may be difficult to explain to non-experts. Thus to appreciate the significance of a one-degree increase in global mean temperature, we perform back-of-the-envelope calculations relying on simple physics. We estimate the excess thermal energy trapped in the climate system (oceans, land, atmosphere) from a one-degree Celsius increase in global mean temperature, and show that it is thousands of times larger than the estimated energy required to form and maintain a hurricane. Our estimates show that global warming is forming a very large pool of excess energy that could in principle power heatwaves, heavy precipitation, droughts, and hurricanes. The arguments presented here are sufficiently simple to be presented in introductory physics classes, and can serve as plausibility arguments showing that even a seemingly small increase in global mean temperature can potentially lead to extreme weather events.
description: 11 pages
Boson sampling with non-identical single photons
Creators: name: Tamma, Vincenzo
name: Laibacher, Simon
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The boson sampling problem has triggered a lot of interest in the scientific community because of its potential of demonstrating the computational power of quantum interference without the need of non-linear processes. However, the intractability of such a problem with any classical device relies on the realization of single photons approximately identical in their spectra. In this paper we discuss the physics of boson sampling with non-identical single photon sources, which is strongly relevant in view of scalable experimental realizations and triggers fascinating questions in complexity theory.
Possible Way to Make MgFeGe a New Fe-based Superconductor
Creators: name: Ding, Ming-Cui
name: Zhang, Yu-Zhong
Publisher: name: arXiv
Year: 2016
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We propose that the contrasting low-temperature behaviors observed experimentally among isostructural and isoelectronic materials, like non-superconducting and nonmagnetic MgFeGe, magnetically ordered NaFeAs, and superconducting LiFeAs, can be well understood from itinerant weak coupling limit. We find that stronger $(π,π)$ instability appearing in the d$_{x^2-y^2}$ orbital of NaFeAs is responsible for the occurrence of weak magnetism while weaker but still prominent $(π,π)$ instability in LiFeAs leads to a superconducting state. In contrast, multiple competing instabilities coexisting in orbital-resolved momentum-dependent susceptibilities, serving as magnetic frustrations from itinerant electrons, may account for the nonmagnetic state in MgFeGe, while poorer Fermi surface nesting leads to a non-superconducting state. Based on above findings, we predict a possible way to make MgFeGe a new Fe-based superconductor.
description: 6 pages, 3 figures
Avoiding unrealistic priors: the case of dark energy constraints from the time variation of the fine-structure constant
Creators: name: Avelino, P. P.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We critically assess recent claims suggesting that upper limits on the time variation of the fine-structure constant tightly constrain the coupling of a dark energy scalar field to the electromagnetic sector, and, indirectly, the violation of the weak equivalence principle. We show that such constraints depend crucially on the assumed priors, even if the dark energy was described by a dynamical scalar field with a constant equation of state parameter $w$ linearly coupled to the electromagnetic sector through a dimensionless coupling $ζ$. We find that, although local atomic clock tests, as well as other terrestrial, astrophysical and cosmological data, put stringent bounds on $|ζ| {\sqrt {|w+1|}}$, the time variation of the fine-structure constant cannot be used to set or to improve upper limits on $|ζ|$ or $|w+1|$ without specifying priors, consistent but not favoured by current data, which strongly disfavour low values of $|w+1|$ or $|ζ|$, respectively. We briefly discuss how this might change with a new generation of high-resolution ultra-stable spectrographs, such as ESPRESSO and ELT-HIRES, in combination with forthcoming missions to map the geometry of the Universe, such as Euclid, or to test the equivalence principle, such as MICROSCOPE or STEP.
description: 7 pages, 5 figures
The First Fall is the Hardest: The Importance of Peculiar Galaxy Dynamics at Infall Time for Tidal Stripping Acting at the Centers of Groups and Clusters
Creators: name: Smith, Rory
name: Calderon-Castillo, Paula
name: Shin, Jihye
name: Raouf, Mojtaba
name: Ko, Jongwan
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Using dark matter only N-body cosmological simulations, we measure the pericentre distance of dark matter halos on their first infall into group and cluster halos. We find that the pericentre distance (R$_{\rm{peri}}$) is an important parameter as it significantly affects the strength of tidal mass loss in dense environments, and likely other environmental mechanisms as well. We examine what determines the R$_{\rm{peri}}$ value and find that, for most infallers, the dominant parameter is V$_{\rm{\perp}}$, the tangential component of the orbital velocity as the halo enters the group/cluster halo for the first time. This means that the strength of tidal stripping acting near the cores of groups/clusters are strongly influenced by the external peculiar velocity field of the large scale structure surrounding them, which differs between clusters, and is sensitive to the mass ratio of infaller to host. We find that filament feeding also partially contributes to feeding in low V$_{\rm{\perp}}$ halos. Dynamical friction can also play a role in reducing R$_{\rm{peri}}$ but this is only significant for those few relatively massive infallers ($>$10\% of the mass of their host). These results highlight how the response of galaxies to dense environments will sensitively depend on dynamics inherited from far outside those dense environments.
description: 18 pages, 12 figures, accepted to ApJ July 10th 2022
Stable Dirac semi-metal in the allotrope of IV elements
Creators: name: Cao, Wendong
name: Tang, Peizhe
name: Zhang, Shou-Cheng
name: Duan, Wenhui
name: Rubio, Angel
Publisher: name: arXiv
Year: 2016
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Three dimensional topological Dirac semi-metals represent a novel state of quantum matter with exotic electronic properties, in which a pair of Dirac points with the linear dispersion along all momentum directions exist in the bulk. Herein, by using the first principles calculations, we discover a new metastable allotrope of Ge and Sn in the staggered layered dumbbell structure, named as germancite and stancite, to be Dirac semi-metals with a pair of Dirac points on its rotation axis. On the surface parallel to the rotation axis, a pair of topologically non-trivial Fermi arcs are observed and a Lifshitz transition is found by tuning the Fermi level. Furthermore, the quantum thin film of germancite is found to be an intrinsic quantum spin Hall insulator. These discoveries suggest novel physical properties and future applications of the new metastable allotrope of Ge and Sn.
description: 4 figures
Ion-atom-atom three-body recombination in cold hydrogen and deuterium plasmas
Creators: name: Cretu, Miruna T.
name: Mirahmadi, Marjan
name: Pérez-Ríos, Jesús
Publisher: name: arXiv
Year: 2022
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: We present a detailed study about ion-atom-atom three-body recombination in hydrogen and deuterium plasmas based on classical trajectory calculations in hyperspherical coordinates. Our results, due to the predominant role of the long-range charged-induced dipole interaction, indicate that H$_2^+$ and D$_2^+$ are the main reaction products in the case of hydrogen and deuterium plasmas, respectively. Besides, we find a more steep energy-dependent reaction rate when the collision energy surpasses the dissociation energy of the molecular ion, thus entering a new dynamical regime dominated by short-range interactions.
description: 6 pages, 3 figures, submitted for publication as a Regular Article in Physical Review A
Accelerating astronomical and cosmological inference with Preconditioned Monte Carlo
Creators: name: Karamanis, Minas
name: Beutler, Florian
name: Peacock, John A.
name: Nabergoj, David
name: Seljak, Uros
Publisher: name: arXiv
Year: 2022
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: We introduce Preconditioned Monte Carlo (PMC), a novel Monte Carlo method for Bayesian inference that facilitates efficient sampling of probability distributions with non-trivial geometry. PMC utilises a Normalising Flow (NF) in order to decorrelate the parameters of the distribution and then proceeds by sampling from the preconditioned target distribution using an adaptive Sequential Monte Carlo (SMC) scheme. The results produced by PMC include samples from the posterior distribution and an estimate of the model evidence that can be used for parameter inference and model comparison respectively. The aforementioned framework has been thoroughly tested in a variety of challenging target distributions achieving state-of-the-art sampling performance. In the cases of primordial feature analysis and gravitational wave inference, PMC is approximately 50 and 25 times faster respectively than Nested Sampling (NS). We found that in higher dimensional applications the acceleration is even greater. Finally, PMC is directly parallelisable, manifesting linear scaling up to thousands of CPUs.
description: 10 pages, 9 figures. Submitted to MNRAS. Code available at https://github.com/minaskar/pocomc
Identification and analysis of functional residues of the VirR response regulator
Creators: name: McGowan., Sheena
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Size control of shape switchable micronetworks by fast two-step microfluidic templating
Creators: name: Frieß, Fabian
name: Lendlein, Andreas
name: Wischke, Christian
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: 610

description: Shape-memory polymer micronetworks (MN) are micrometer-sized objects that can switch their outer shape upon external command. This study aims to scale MN sizes to the low micrometer range at very narrow size distributions. In a two-step microfluidic strategy, the specific design of coaxial class capillary devices allowed stabilizing the thread of the dispersed phase to efficiently produce precursor particles in the tip-streaming regime at rates up to ~ 170 kHz and final sizes down to 4 µm. In a subsequent melt-based microfluidic photocrosslinking of the methacrylate-functionalized oligo(ɛ-caprolactone) precursor material, MN could be produced without particle aggregation. A comprehensive analysis of MN properties illustrated successful crosslinking, semi-crystalline morphology, and a shape-switching functionality for all investigated MN sizes (4, 6, 9, 12, 22 µm). Such functional micronetworks tailored to and below the dimension of cells can enable future applications in technology and medicine like controlling cell interaction.
Neuronal pentraxins as biomarkers of synaptic activity : from physiological functions to pathological changes in neurodegeneration
Creators: name: Gómez De San José, Nerea
name: Massa, Federico
name: Halbgebauer, Steffen
name: Oeckl, Patrick
name: Steinacker, Petra
name: Otto, Markus
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 610

description: The diagnosis of neurodegenerative disorders is often challenging due to the lack of diagnostic tools, comorbidities and shared pathological manifestations. Synaptic dysfunction is an early pathological event in many neurodegenerative disorders, but the underpinning mechanisms are still poorly characterised. Reliable quantification of synaptic damage is crucial to understand the pathophysiology of neurodegeneration, to track disease status and to obtain prognostic information. Neuronal pentraxins (NPTXs) are extracellular scaffolding proteins emerging as potential biomarkers of synaptic dysfunction in neurodegeneration. They are a family of proteins involved in homeostatic synaptic plasticity by recruiting post-synaptic receptors into synapses. Recent research investigates the dynamic changes of NPTXs in the cerebrospinal fluid (CSF) as an expression of synaptic damage, possibly related to cognitive impairment. In this review, we summarise the available data on NPTXs structure and expression patterns as well as on their contribution in synaptic function and plasticity and other less well-characterised roles. Moreover, we propose a mechanism for their involvement in synaptic damage and neurodegeneration and assess their potential as CSF biomarkers for neurodegenerative diseases.
A mechanically strong and ductile soft magnet with extremely low coercivity
Creators: name: Han, Liuliu
name: Maccari, Fernando
name: Filho, Isnaldi R. Souza
name: Peter, Nicolas J.
name: Wei, Ye
name: Gault, Baptiste
name: Gutfleisch, Oliver
name: Li, Zhiming
name: Raabe, Dierk
Publisher: name: arXiv
Year: 2022
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Other Condensed Matter (cond-mat.other)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: Soft magnetic materials (SMMs) serve in electrical applications and sustainable energy supply, allowing magnetic flux variation in response to changes in applied magnetic field, at low energy loss1. The electrification of transport, households and manufacturing leads to an increase in energy consumption due to hysteresis losses2. Therefore, minimizing coercivity, which scales these losses, is crucial3. Yet, meeting this target alone is not enough: SMMs in electrical engines must withstand severe mechanical loads, i.e., the alloys need high strength and ductility4. This is a fundamental design challenge, as most methods that enhance strength introduce stress fields that can pin magnetic domains, thus increasing coercivity and hysteretic losses5. Here, we introduce an approach to overcome this dilemma. We have designed a Fe-Co-Ni-Ta-Al multicomponent alloy with ferromagnetic matrix and paramagnetic coherent nanoparticles (~91 nm size, ~55% volume fraction). They impede dislocation motion, enhancing strength and ductility. Their small size, low coherency and small magnetostatic energy create an interaction volume below the magnetic domain wall width, leading to minimal domain wall pinning, thus maintaining the soft magnetic properties. The alloy has a tensile strength of 1336 MPa at 54% tensile elongation, extremely low coercivity of 78 A/m (<1 Oe), moderate saturation magnetization of 100 Am2/kg, and high electrical resistivity of 103 μΩ u Ohm cm.
description: 24 pages
Additional file 2 of MitoHiFi: a python pipeline for mitochondrial genome assembly from PacBio high fidelity reads
Creators: name: Uliano-Silva, Marcela
name: Ferreira, João Gabriel R. N.
name: Krasheninnikova, Ksenia
name: Formenti, Giulio
name: Abueg, Linelle
name: Torrance, James
name: Myers, Eugene W.
name: Durbin, Richard
name: Blaxter, Mark
name: McCarthy, Shane A.
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2. List of species that were assembled by MitoHiFi and that also had previous mitogenomes available on online databases.
Technique Report: Near-Optimal Routing Protection for SDN Networks Using Distributed Markov Approximation
Creators: name: Huang, Huawei
name: Guo, Song
name: Liang, Weifa
name: Li, Keqiu
name: Ye, Baoliu
Publisher: name: arXiv
Year: 2016
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Software Defined Networking (SDN) brings numbers of advantages along with many challenges. One particular concern is on the control-plane resilience, while the existing protection approaches proposed for SDN networks mainly focus on data-plane. In order to achieve the carrier-grade recovery from link failures, we adopt the dedicated protection scheme towards finding optimal protection routing for control-plane traffic. To this end, we study a weighted cost minimization problem, in which the traffic load balancing and flow table rule placement are jointly considered when selecting protection paths for controller-switch sessions. Because this problem is known as NP-hard, we propose a Markov approximation based combinatorial optimization approach for routing protection in SDN control-plane, which produces near-optimal solution in a distributed fashion. We then extend our solution to an on-line case that can handle the single-link failure one at a time. The induced performance fluctuation is also analyzed with theoretical derivation. Extensive experimental results show that our proposed algorithm has fast convergence and high efficiency in resource utilization.
description: This paper has been withdrawn by the author due to a crucial presentation error in Algorithm 1
The development of the Royal Park multidiagnostic instrument for psychosis and its application in examining the clarity and stability of the clinical picture in functional psychosis
Creators: name: McGorry., Patrick Dennistoun
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Flow sensing by buckling monitoring of electrothermally actuated double-clamped micro beams
Creators: name: Kessler, Yoav
name: Krylov, Slava
name: Liberzon, Alex
Publisher: name: arXiv
Year: 2016
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We report on a flow sensing approach based on deflection monitoring of micro beams buckled by the compressive thermal stress due to electrothermal Joules heating. The air stream convectively cooling the device affects both the critical buckling values of the electric current and the postbuckling deflections of the structure. After calibration, the flow velocity was obtained from the deflections measurements. The quasi-static responses of 2000 microns long, 10 microns wide and 30 microns high single crystal silicon beam transduced using image processing were consistent with the prediction of the reduced order model, which couples thermoelectric, thermofluidic and structural domains. The deflection sensitivity of 1.5 microns/(m/s) and the critical current sensitivity of 0.4 mA/(m/s) were registered in the experiments. Our model and experimental results collectively demonstrate feasibility of the sensing approach and further suggest that simple, robust and potentially downscalable beam-type devices may have use in flow velocity and wall shear stress sensors.
Impact of Radiation Feedback on the Formation of Globular Cluster Candidates during Cloud-Cloud Collisions
Creators: name: Han, Daniel
name: Kimm, Taysun
name: Katz, Harley
name: Devriendt, Julien
name: Slyz, Adrianne
Publisher: name: arXiv
Year: 2022
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: To understand the impact of radiation feedback during the formation of a globular cluster (GC), we simulate a head-on collision of two turbulent giant molecular clouds (GMCs). A series of idealized radiation-hydrodynamic simulations is performed, with and without stellar radiation or Type II supernovae. We find that a gravitationally bound, compact star cluster of mass $M_{\rm GC} \sim 10^5\,M_\odot$ forms within $\approx 3\,{\rm Myr}$ when two GMCs with mass $M_{\rm GMC}=3.6\times10^5\,M_\odot$ collide. The GC candidate does not form during a single collapsing event but emerges due to the mergers of local dense gas clumps and gas accretion. The momentum transfer due to the absorption of the ionizing radiation is the dominant feedback process that suppresses the gas collapse and photoionization becomes efficient once a sufficient number of stars form. The cluster mass is larger by a factor of $\sim 2$ when the radiation feedback is neglected, and the difference is slightly more pronounced (16\%) when extreme $\rm Lyα$ feedback is considered in the fiducial run. In the simulations with radiation feedback, supernovae explode after the star-forming clouds are dispersed, and their metal ejecta are not instantaneously recycled to form stars.
description: 14 pages, 7 figures, Accepted for publication in the Astrophysical Journal
YBX1 mediates translation of oncogenic transcripts to control cell competition in AML
Creators: name: Perner, Florian
name: Schnöder, Tina
name: Xiong, Yijun
name: Jayavelu, Ashok Kumar
name: Mashamba, Nomusa
name: Santamaria, Nuria Tubio
name: Huber, Nicolas
name: Todorova, Kristina
name: Hatton, Charles
name: Perner, Birgit
name: Eifert, Theresa
name: Murphy, Ciara
name: Hartmann, Maximilian
name: Höll, Jessica
name: Schröder, Nicolas Wolfgang Jörg
name: Brandt, Sabine
name: Hochhaus, Andreas
name: Mertens, Peter Rene
name: Mann, Matthias
name: Armstrong, Scott A.
name: Mandinova, Anna
name: Heidel, Florian
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 610

description: Persistence of malignant clones is a major determinant of adverse outcome in patients with hematologic malignancies. Despite the fact that the majority of patients with acute myeloid leukemia (AML) achieve complete remission after chemotherapy, a large proportion of them relapse as a result of residual malignant cells. These persistent clones have a competitive advantage and can re-establish disease. Therefore, targeting strategies that specifically diminish cell competition of malignant cells while leaving normal cells unaffected are clearly warranted. Recently, our group identified YBX1 as a mediator of disease persistence in JAK2-mutated myeloproliferative neoplasms. The role of YBX1 in AML, however, remained so far elusive. Here, inactivation of YBX1 confirms its role as an essential driver of leukemia development and maintenance. We identify its ability to amplify the translation of oncogenic transcripts, including MYC, by recruitment to polysomal chains. Genetic inactivation of YBX1 disrupts this regulatory circuit and displaces oncogenic drivers from polysomes, with subsequent depletion of protein levels. As a consequence, leukemia cells show reduced proliferation and are out-competed in vitro and in vivo, while normal cells remain largely unaffected. Collectively, these data establish YBX1 as a specific dependency and therapeutic target in AML that is essential for oncogenic protein expression.
Additional file 3 of MitoHiFi: a python pipeline for mitochondrial genome assembly from PacBio high fidelity reads
Creators: name: Uliano-Silva, Marcela
name: Ferreira, João Gabriel R. N.
name: Krasheninnikova, Ksenia
name: Formenti, Giulio
name: Abueg, Linelle
name: Torrance, James
name: Myers, Eugene W.
name: Durbin, Richard
name: Blaxter, Mark
name: McCarthy, Shane A.
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3. Figure 1. Dotplots of MitoHiFi mitogenomes (x axis) with their pre-existing mitogenome assemblies (y axis) for each species.
Permutation p-values should never be zero: calculating exact p-values when permutations are randomly drawn
Creators: name: Phipson, Belinda
name: Smyth, Gordon K.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Applications (stat.AP)
subject: FOS: Computer and information sciences
subject: 62G09, 62G10

description: Permutation tests are amongst the most commonly used statistical tools in modern genomic research, a process by which p-values are attached to a test statistic by randomly permuting the sample or gene labels. Yet permutation p-values published in the genomic literature are often computed incorrectly, understated by about 1/m, where m is the number of permutations. The same is often true in the more general situation when Monte Carlo simulation is used to assign p-values. Although the p-value understatement is usually small in absolute terms, the implications can be serious in a multiple testing context. The understatement arises from the intuitive but mistaken idea of using permutation to estimate the tail probability of the test statistic. We argue instead that permutation should be viewed as generating an exact discrete null distribution. The relevant literature, some of which is likely to have been relatively inaccessible to the genomic community, is reviewed and summarized. A computation strategy is developed for exact p-values when permutations are randomly drawn. The strategy is valid for any number of permutations and samples. Some simple recommendations are made for the implementation of permutation tests in practice.
description: 12 pages, 2 figures
Pirfenidone vs. nintedanib in patients with idiopathic pulmonary fibrosis : a retrospective cohort study
Creators: name: Marijic, Pavo
name: Schwarzkopf, Larissa
name: Schwettmann, Lars
name: Ruhnke, Thomas
name: Trudzinski, Franziska
name: Kreuter, Michael
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: 610

description: Background: Two antifibrotic drugs, pirfenidone and nintedanib, are licensed for the treatment of patients with idiopathic pulmonary fibrosis (IPF). However, there is neither evidence from prospective data nor a guideline recommendation, which drug should be preferred over the other. This study aimed to compare pirfenidone and nintedanib-treated patients regarding all-cause mortality, all-cause and respiratory-related hospitalizations, and overall as well as respiratory-related health care costs borne by the Statutory Health Insurance (SHI). Methods: A retrospective cohort study with SHI data was performed, including IPF patients treated either with pirfenidone or nintedanib. Stabilized inverse probability of treatment weighting (IPTW) based on propensity scores was applied to adjust for observed covariates. Weighted Cox models were estimated to analyze mortality and hospitalization. Weighted cost differences with bootstrapped 95% confidence intervals (CI) were applied for cost analysis. Results: We compared 840 patients treated with pirfenidone and 713 patients treated with nintedanib. Both groups were similar regarding two-year all-cause mortality (HR: 0.90 95% CI: 0.76; 1.07), one-year all cause (HR: 1.09, 95% CI: 0.95; 1.25) and respiratory-related hospitalization (HR: 0.89, 95% CI: 0.72; 1.08). No significant differences were observed regarding total (€− 807, 95% CI: €− 2977; €1220) and respiratory-related (€− 1282, 95% CI: €− 3423; €534) costs. Conclusion: Our analyses suggest that the patient-related outcomes mortality, hospitalization, and costs do not differ between the two currently available antifibrotic drugs pirfenidone and nintedanib. Hence, the decision on treatment with pirfenidone versus treatment with nintedanib ought to be made case-by-case taking clinical characteristics, comorbidities, comedications, individual risk of side effects, and patients’ preferences into account.
Structure of turbulence in the flow around a rectangular cylinder
Creators: name: Chiarini, Alessandro
name: Gatti, Davide
name: Cimarelli, Andrea
name: Quadrio, Maurizio
Publisher: name: arXiv
Year: 2022
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: The separating and reattaching turbulent flow past a rectangular cylinder is studied to describe how small and large scales contribute to the sustaining mechanism of the velocity fluctuations. The work is based on the Anisotropic Generalised Kolmogorov Equations (AGKE), exact budget equations for the second-order structure function tensor in the space of scales and in the physical space. Scale-space energy fluxes show that forward and reverse energy transfers simultaneously occur in the flow, with interesting modelling implications. Over the longitudinal cylinder side, the Kelvin-Helmholtz instability of the leading-edge shear layer generates large spanwise rolls, which get stretched into hairpin-like vortices and eventually break down into smaller streamwise vortices. Independent sources of velocity fluctuations act at different scales. The flow dynamics is dominated by pressure-strain: the flow impingement on the cylinder surface in the reattachment zone produces spanwise velocity fluctuations very close to the wall and, at larger wall distances, reorients them to feed streamwise-aligned vortices. In the near wake, large von Kàrmàn-like vortices are shed from the trailing edge and coexist with smaller turbulent structures, each with its own independent production mechanism. At the trailing edge, the sudden disappearance of the wall changes the structure of turbulence: streamwise vortices progressively vanish, while spanwise structures close to the wall are suddenly turned into vertical fluctuations by the pressure strain.
Reduced vestibular perception thresholds in persistent postural-perceptual dizziness : a cross-sectional study
Creators: name: Wurthmann, Sebastian
name: Holle-Lee, Dagny
name: Obermann, Mark
name: Roesner, Miriam
name: Nsaka, Michael
name: Scheffler, Armin
name: Kleinschnitz, Christoph
name: Naegel, Steffen
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2021
Subjects: subject: 610

description: Background: Persistent postural-perceptual dizziness (PPPD) is the most common functional vestibular disorder. A multisensory mismatch altered by psychological influences is considered to be an important pathophysiological mechanism. Increased cortical and subcortical excitability may play a role in the pathophysiology of PPPD. We hypothesized that decreased motion perception thresholds reflect one mechanism of the abnormal vestibular responsiveness in this disorder. We investigated the vestibular perception thresholds and the vestibular ocular reflex with a rotatory chair experiment to gain insights in the processing and adaption to vestibular provocation. Methods: In this cross-sectional study 26 female PPPD patients and 33 healthy female age matched controls (HC) were investigated sitting in a motorized rotary chair shielded regarding visual and acoustic stimuli. The chair was rotated for 20 minutes with slowly increasing velocity to a maximum of 72°/s. We functionally tested motion perception thresholds and vegetative responses to rotation as well as vestibular-ocular reflex thresholds. We additionally investigated several psychological comorbidities (i.e. depression, anxiety, somatosensory amplification) using validated scores. Conventional dizziness scores were obtained to quantify the experienced dizziness and impact on daily life. Results: PPPD patients showed a significant reduced vestibulo-perceptual threshold (PPPD: 10.9°/s vs. HC: 29.5°/s; p<0.001) with increased motion sensitivity and concomitant vegetative response during and after the chair rotation compared to healthy controls. The extent of increased vestibular sensitivity was in correlation with the duration of the disease (p=0.043). No significant difference was measured regarding nystagmus parameters between both groups. Conclusion: PPPD patients showed increased vegetative response as well as decreased vestibulo-perceptual thresholds which are related to disease duration. This is of interest as PPPD might be sustained by increased vestibular excitability leading to motion intolerance and induction of dizziness when exposed to movement.
Tesla : an application for real-time data analysis in High Energy Physics
Creators: name: Aaij, R.
name: Amato, S.
name: Anderlini, L.
name: Benson, S.
name: Cattaneo, M.
name: Clemencic, M.
name: Couturier, B.
name: Frank, M.
name: Gligorov, V. V.
name: Head, T.
name: Jones, C.
name: Komarov, I.
name: Lupton, O.
name: Matev, R.
name: Raven, G.
name: Sciascia, B.
name: Skwarnicki, T.
name: Spradlin, P.
name: Stahl, S.
name: Storaci, B.
name: Vesterinen, M.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Upgrades to the LHCb computing infrastructure in the first long shutdown of the LHC have allowed for high quality decay information to be calculated by the software trigger making a separate offline event reconstruction unnecessary. Furthermore, the storage space of the triggered candidate is an order of magnitude smaller than the entire raw event that would otherwise need to be persisted. Tesla, following the LHCb renowned physicist naming convention, is an application designed to process the information calculated by the trigger, with the resulting output used to directly perform physics measurements.
description: 14 pages, 8 figures
Bridging The Gap In Rural Health Communications: A Preliminary Study
Creators: Elizabeth T.
Publisher: name: University of Alberta Library
Year: 2023

I lived in a rural town in northeastern Alberta for the last five years where access to healthcare has always been challenging and tenuous. Prior to the pandemic, recruiting and retaining quality healthcare professionals in rural areas was already difficult (Matthews & Park, 2007), and while the situation was not ideal, it was not dire. Post-pandemic circumstances, however, saw frequent emergency room closures all across Canada, with hospital beds left empty due to the lack of nursing staff (Kitching, 2022). In the past year, rural residents in the area I live in, Cold Lake, have taken to social media to find doctor availability and emergency room wait times. This information enables them to determine if the emergency room is available and make informed decisions regarding undertaking travel to a hospital where they may have the best chances of being seen by a doctor. The situation in healthcare was made worse by COVID-19 as the loss of qualified healthcare personnel is particularly felt in rural areas (Lowrie, 2022). Based on this experience, the research questions guiding this inquiry are: How are residents in rural communities using social media to help them make informed decisions about doctors and the availability of healthcare services? Why are residents in rural areas using social media to help them make informed decisions regarding healthcare?
Buoyancy segregation suppresses viscous fingering in horizontal displacements in a porous layer
Creators: name: Hinton, Edward M.
name: Jyoti, Apoorv
Publisher: name: arXiv
Year: 2022
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We consider the axisymmetric displacement of an ambient fluid by a second input fluid of lower density and lower viscosity in a horizontal porous layer. If the two fluids have been vertically segregated by buoyancy, the flow becomes self-similar with the input fluid preferentially flowing near the upper boundary. We show that this axisymmetric self-similar flow is stable to angular-dependent perturbations for any viscosity ratio. The Saffman-Taylor instability is suppressed due to the buoyancy segregation of the fluids. The radial extent of the segregated current is inversely proportional to the viscosity ratio. This horizontal extension of the intrusion eliminates the discontinuity in the pressure gradient between the fluids associated with the viscosity contrast. Hence, at late times viscous fingering is shut down even for arbitrarily small density differences. The stability is confirmed through numerical integration of a coupled problem for the interface shape and the pressure gradient, and through complementary asymptotic analysis, which predicts the decay rate for each mode. The results are extended to anisotropic and vertically heterogeneous layers. The interface may have steep shock-like regions but the flow is always stable when the fluids have been segregated by buoyancy, as in a uniform layer.
description: 10 figures, 24 pages
The 31 kD antigen complex of L3 Ostertagia circumcincta larvae
Creators: name: McGillivery., Duncan J.
Publisher: name: Monash University
Year: 2021

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Additional file 4 of MitoHiFi: a python pipeline for mitochondrial genome assembly from PacBio high fidelity reads
Creators: name: Uliano-Silva, Marcela
name: Ferreira, João Gabriel R. N.
name: Krasheninnikova, Ksenia
name: Formenti, Giulio
name: Abueg, Linelle
name: Torrance, James
name: Myers, Eugene W.
name: Durbin, Richard
name: Blaxter, Mark
name: McCarthy, Shane A.
Publisher: name: figshare
Year: 2023
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 4. Figure 2. Screenshots of IGV plots of reads mapped back to Andrea bucephala mitogenome before and after NUMTs reads were removed.