cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The receptor binding domain of the viral spike protein is  an immunodominant and highly specific target of  antibodies in SARS-CoV-2 patients
Creators: name: Tse, Longping V.
name: Segovia-Chumbez, Bruno
name: Edwards, Caitlin E.
name: Weiskopf, Daniela
name: Sette, Alessandro
name: Collins, Matthew H.
name: Baric, Ralph S.
name: Schmitz, John
name: Rouphael, Nadine
name: Martinez, David R.
name: Premkumar, Lakshmanane
name: Weiss, Susan
name: Markmann, Alena
name: Park, Yara
name: Hou, Yixuan J.
name: Scherer, Erin M.
name: Edupuganti, Srilatha
name: Raut, Rajendra
name: de Silva, Aravinda
name: Bartlet, Luther
name: Jadi, Ramesh
name: Cornaby, Caleb
name: Weimer, Eric
name: Margolis, David
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that first emerged in late 2019 is responsible for a pandemic of severe respiratory illness. People infected with this highly contagious virus can present with clinically inapparent, mild, or severe disease. Currently, the virus infection in individuals and at the population level is being monitored by PCR testing of symptomatic patients for the presence of viral RNA. There is an urgent need for SARS-CoV-2 serologic tests to identify all infected individuals, irrespective of clinical symptoms, to conduct surveillance and implement strategies to contain spread. As the receptor binding domain (RBD) of the spike protein is poorly conserved between SARS-CoVs and other pathogenic human coronaviruses, the RBD represents a promising antigen for detecting CoV-specific antibodies in people. Here we use a large panel of human sera (63 SARS-CoV-2 patients and 71 control subjects) and hyperimmune sera from animals exposed to zoonotic CoVs to evaluate RBD's performance as an antigen for reliable detection of SARS-CoV-2-specific antibodies. By day 9 after the onset of symptoms, the recombinant SARS-CoV-2 RBD antigen was highly sensitive (98%) and specific (100%) for antibodies induced by SARS-CoVs. We observed a strong correlation between levels of RBD binding antibodies and SARS-CoV-2 neutralizing antibodies in patients. Our results, which reveal the early kinetics of SARS-CoV-2 antibody responses, support using the RBD antigen in serological diagnostic assays and RBD-specific antibody levels as a correlate of SARS-CoV-2 neutralizing antibodies in people.
A unified statistical model of protein multiple sequence alignment integrating direct coupling and insertions
Creators: name: Kinjo, Akira R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Biomolecules (q-bio.BM)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: The multiple sequence alignment (MSA) of a protein family provides a wealth of information in terms of the conservation pattern of amino acid residues not only at each alignment site but also between distant sites. In order to statistically model the MSA incorporating both short-range and long-range correlations as well as insertions, I have derived a lattice gas model of the MSA based on the principle of maximum entropy. The partition function, obtained by the transfer matrix method with a mean-field approximation, accounts for all possible alignments with all possible sequences. The model parameters for short-range and long-range interactions were determined by a self-consistent condition and by a Gaussian approximation, respectively. Using this model with and without long-range interactions, I analyzed the globin and V-set domains by increasing the "temperature" and by "mutating" a site. The correlations between residue conservation and various measures of the system's stability indicate that the long-range interactions make the conservation pattern more specific to the structure, and increasingly stabilize better conserved residues.
description: 21 pages (2-column), 13 figures
Marsch und Variationen für Guitarre
Creators: name: Hünten, Peter-Ernst
name: Hünten, Franz
Publisher: name: [19. Jh.]
Year: 1800

description: P.E. Hünten
description: Früher katalogisiert mit Franz Hünten als Komponist
description: Offenbar unvollständig: Unter dem hier letzten Takt der Hinweis "attacca Var: 3:", die dann aber nicht mehr vorhanden ist.
description: Geschenk 1941 *41,ab2 Öffentliche Bibliothek der Universität Basel
description: Verzeichnung=Description=Inventaire 2009 Übernahme Rekatalogis. AK UB durch Medea 2002-2005
description: Verzeichnung=Description=Inventaire Januar 2019 HAN-Katalogisierungsregeln
Galaxy And Mass Assembly (GAMA): The Bright Void Galaxy Population in the Optical and Mid-IR
Creators: name: Penny, S. J.
name: Brown, M. J. I.
name: Pimbblet, K. A.
name: Cluver, M. E.
name: Croton, D. J.
name: Owers, M. S.
name: Lange, R.
name: Alpaslan, M.
name: Baldry, I.
name: Bland-Hawthorn, J.
name: Brough, S.
name: Driver, S. P.
name: Holwerda, B. W.
name: Hopkins, A. M.
name: Jarrett, T. H.
name: Jones, D. Heath
name: Kelvin, L. S.
name: Lara-Lopez, M. A.
name: Liske, J.
name: Lopez-Sanchez, A. R.
name: Loveday, J.
name: Meyer, M.
name: Norberg, P.
name: Robotham, A. S. G.
name: Rodrigues, M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We examine the properties of galaxies in the Galaxies and Mass Assembly (GAMA) survey located in voids with radii $>10~h^{-1}$ Mpc. Utilising the GAMA equatorial survey, 592 void galaxies are identified out to z~0.1 brighter than $M_{r} = -18.4$, our magnitude completeness limit. Using the $W_{\rm{Hα}}$ vs. [NII]/H$α$ (WHAN) line strength diagnostic diagram, we classify their spectra as star forming, AGN, or dominated by old stellar populations. For objects more massive than $5\times10^{9}$ M$_{\odot}$, we identify a sample of 26 void galaxies with old stellar populations classed as passive and retired galaxies in the WHAN diagnostic diagram, else they lack any emission lines in their spectra. When matched to WISE mid-IR photometry, these passive and retired galaxies exhibit a range of mid-IR colour, with a number of void galaxies exhibiting [4.6]-[12] colours inconsistent with completely quenched stellar populations, with a similar spread in colour seen for a randomly drawn non-void comparison sample. We hypothesise that a number of these galaxies host obscured star formation, else they are star forming outside of their central regions targeted for single fibre spectroscopy. When matched to a randomly drawn sample of non-void galaxies, the void and non-void galaxies exhibit similar properties in terms of optical and mid-IR colour, morphology, and star formation activity, suggesting comparable mass assembly and quenching histories. A trend in mid-IR [4.6]-[12] colour is seen, such that both void and non-void galaxies with quenched/passive colours <1.5 typically have masses higher than $10^{10}$ M$_{\odot}$, where internally driven processes play an increasingly important role in galaxy evolution.
description: 22 pages, 12 figures. Accepted for publication in MNRAS
Roots in the semiring of finite deterministic dynamical systems
Creators: name: Doré, François
name: Perrot, Kévin
name: Porreca, Antonio E.
name: Riva, Sara
name: Rolland, Marius
Publisher: name: arXiv
Year: 2024
Subjects: subject: Discrete Mathematics (cs.DM)
subject: Dynamical Systems (math.DS)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: Finite discrete-time dynamical systems (FDDS) model phenomena that evolve deterministically in discrete time. It is possible to define sum and product operations on these systems (disjoint union and direct product, respectively) giving a commutative semiring. This algebraic structure led to several works employing polynomial equations to model hypotheses on phenomena modelled using FDDS. To solve these equations, algorithms for performing the division and computing $k$-th roots are needed. In this paper, we propose two polynomial algorithms for these tasks, under the condition that the result is a connected FDDS. This ultimately leads to an efficient solution to equations of the type $AX^k=B$ for connected $X$. These results are some of the important final steps for solving more general polynomial equations on FDDS.
Runaway Kaposi Sarcoma-associated herpesvirus replication correlates with systemic IL-10 levels
Creators: name: Fischer II, William A.
name: Caro-Vegas, Carolina
name: Host, Kurtis M.
name: Seltzer, Jedidiah
name: Damania, Blossom
name: Dittmer, Dirk
name: Sellers, Subhashini
name: Landis, Justin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: KSHV-associated inflammatory cytokine syndrome (KICS) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV). KICS is associated with high-level, systemic replication of KSHV. This study characterized the clinical and virologic features of a KICS patient over time. Additionally, it compared the cytokine profiles of the KICS case to Kaposi's sarcoma (KS) (n = 11) and non-KS (n = 6) cases. This KICS case presented with elevated levels of KSHV and IL-10, as expected. Surprisingly, this case did not have elevated levels of IL-6 or human immunodeficiency virus 1 (HIV-1). Nevertheless, treatment with anti-IL6 receptor antibody (tocilizumab) reduced KSHV viral load and IL-10. The KSHV genome sequence showed no significant changes over time, except in ORF24. Phylogenetic analysis established this isolate as belonging to KSHV clade A and closely related to other US isolates. These findings suggest IL-10 as potential biomarker and therapy target for KICS.
6 Stücke für 2 Guitarren
Creators: name: Hünten, Franz
name: Hünten, Peter-Ernst
name: Carulli, Ferdinando
Publisher: name: [s.n.]
Year: 1800

description: Mit Bleistift ist vermerkt, dass der Komponist des ersten Stückes Franz Hünten ist, es könnte aber auch Peter-Ernst Hünten sein
description: Geschenk 1941 *41,ab2 Öffentliche Bibliothek der Universität Basel
description: Verzeichnung=Description=Inventaire 2009 Übernahme Rekatalogis. AK UB durch Medea 2002-2005
description: Verzeichnung=Description=Inventaire Januar 2019 HAN-Katalogisierungsregeln
The Dragonfly Ultrawide Survey: Design and Early Science
Creators: name: Bowman, William P.
name: van Dokkum, Pieter
name: Abraham, Roberto
name: Janssens, Steven R.
name: Shen, Zili
name: Liu, Qing
Publisher: name: Zenodo
Year: 2023

description: The low surface brightness universe encodes key information about galaxy formation and evolution, yet it is a challenging regime to study. The Dragonfly Telephoto Array is uniquely optimized for investigating low surface brightness phenomena, with its large (6 sq. deg.) field of view and relatively unobstructed light optical path, leading to significantly less scattered light compared to traditional telescope designs. We have recently completed the Dragonfly Ultrawide Survey, which covers roughly a quarter of the sky (~ 10,000 sq. deg.) in g- and r-band imaging and overlaps with the entire SDSS footprint. The 30-minute integration times yield surface brightness limits below 29 mag/arcsec2 on 1x1' scales. The large survey footprint, combined with Dragonfly's unprecedented sensitivity to low surface brightness features and exquisite control over background systematics, enables us to explore key questions about the low surface brightness universe. The primary science of the Ultrawide survey is to detect the largest, nearest (d < 20 Mpc) Ultra Diffuse Galaxies (UDGs). I will present an overview of the Dragonfly Ultrawide Survey and highlight the initial science results from the survey, including the search for as-yet undetected UDGs.
(103847) Eliza Gay
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Nationaler DKD-Ringvergleich für Strömungsgeschwindigkeit (Transfernormal: Prandtl-Rohr mit Auswerteeinheit Kalibrierbereich: 5 m/s bis 50 m/s) : Vergleichsbericht DKD-V 11-1
Creators: name: Physikalisch-Technische Bundesanstalt, Braunschweig
Publisher: name: Physikalisch-Technische Bundesanstalt (PTB)
Year: 2019
Subjects: Vergleichsmessungen
Ringvergleich
Strömungsgeschwindigkeit
Prandtl´schen Staurohr

description: Der vorliegende PTB/DKD Ringvergleich erfolgte zwischen 8 Kalibrierlaboratorien und der PTB. Dabei wurde als Transfernormal ein Prandtl´schen Staurohr mit beigestellter Sensorik und Auswerteeinheit verwendet. Ziel war es, möglichst kleine Rückwirkungen in den einzelnen Messeinrichtungen mit einem möglichst großen Strömungsgeschwindigkeitsbereich von 5 m/s bis 50 m/s abzudecken. Die Ergebnisse sind in anonymisierter Form zusammengefasst dargestellt.
Age-associated changes in the respiratory epithelial response to influenza infection
Creators: name: Jaspers, Ilona
name: Armistead, Paul M.
name: Sellers, Subhashini
name: Chason, Kelly D.
name: Hansucker, Sally A.
name: Fischer II, William A.
name: Parker, Joel
name: Brighton, Louisa
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: Older adults suffer a disproportionate burden of influenza-related morbidity and mortality typically attributed to defects in the aging immune system collectively known as immunosenescence. While the age-related decline in the adaptive immune system has been well characterized, little is known about how aging affects the principal site of influenza infection—the nasal epithelium. In human nasal epithelial cell cultures (hNECs) from older adults, we found similar or increased levels of cytokines during influenza infection compared with hNECs from younger individuals. However, hNECs from older individuals demonstrated decreased mRNA expression for several key proteins that affect clearance of infected cells, including MHC-I and transporter associated with antigen presentation (TAP). These findings were confirmed at the level of protein expression. In vivo studies corroborated the in vitro differences in MHC-I and TAP gene expression and also revealed important decreases in the expression of key influenza-specific antiviral mediators MX1 and IFITM1. Furthermore, epithelial cell-cytotoxic T lymphocyte co-cultures demonstrate that CTL cytotoxic activity is dose-dependent on MHC-I antigen presentation. Taken together, these results indicate that aging is associated with important changes in the nasal epithelium, including antigen presentation and antiviral pathways, which may contribute to increased severity of disease in older adults through impaired clearance of infected cells.
(103849) Emily Curtis
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Born-Infeld electrodynamics in very special relativity
Creators: name: Bufalo, R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this work we discuss the properties of a modified Born-Infeld electrodynamics in the framework of very special relativity (VSR). This proposal allows us to study VSR mass effects in a gauge-invariant context of nonlinear electrodynamics. It is analyzed in detail the electrostatic solutions for two different cases, as well as the VSR dispersion relations are found to be of a \emph{massive} particle with nonlinear modifications. Afterwards, the field energy and static potential are computed, in the latter we find from the VSR contribution a novel long-range $1/L^3$ correction to the Coulomb potential, in contrast to the $1/L^5$ correction of the usual Born-Infeld theory.
description: 14 pages; to appear in PLB
1 Brief an [Franz] X[aver] Schnyder v[on] Wartensee
Brief an Schnyder von Wartensee ...
Creators: name: Nägeli, Hans Georg
Publisher: name: [s.n.]
Year: 1826

description: von H[an]s Georg Nägeli
description: Ort und Datum nach Poststempel und nachträglich von fremder Hand notiert
Errors in Diagnostic Test Use and Interpretation Contribute to the High Number of Lyme Disease Referrals in a Low-Incidence State
Creators: name: Lin, Jessica T.
name: Farel, Claire E.
name: Speight, Carly
name: Boyce, Ross M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: Lyme disease accounted for more than two-thirds (56 of 81,
69.1%) of all tick-borne disease referrals to a large, academic
infectious diseases clinic in a low-incidence state. Deviations
from diagnostic testing guidelines and errors in test interpretation
were common (23 of 35, 65.7%), suggesting that frontline
providers need additional clinical support.
Combining LEP and LHC to bound the Higgs Width
Creators: name: Englert, Christoph
name: McCullough, Matthew
name: Spannowsky, Michael
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The correlation of on- and off-shell Higgs boson production at the LHC in $gg \to h^* \to ZZ$ to bound the Higgs width, under specific model-dependent assumptions, has recently received a lot of attention. As off-shell cross section measurements in this channel suffer from a small signal yield, large backgrounds, and theoretical uncertainties, we propose an alternative complementary constraint which is only possible through the combination of LEP and LHC measurements. Previous precision electroweak measurements at LEP allow for the determination of indirect constraints on Higgs couplings to vector bosons by considering one-loop processes involving virtual Higgs exchange. As the Higgs is off-shell in these diagrams we venture that LEP can be interpreted as an off-shell `Higgs Factory'. By combining these LEP constraints with current LHC 8 TeV Higgs measurements a stronger limit on the Higgs width can be achieved than with LHC data alone for models with rescaled Higgs couplings. Looking to the future, avoiding ambiguities arising due to new physics modifications of the $hGG$ coupling, a theoretically more robust constraint can be achieved by correlating LEP measurements with WBF Higgs production followed by Higgs decays to $WW$ and $ZZ$. This method for indirectly constraining the Higgs width is very effective for specific BSM scenarios and is highly complementary to other proposed methods. The limits we obtain particularly highlight the power of a concrete LEP+LHC combination, not only limited to Higgs width measurements.
description: 17 pages
Dirac operators on the half-line: stability of spectrum and non-relativistic limit
Creators: name: Kramar, David
name: Krejcirik, David
Publisher: name: arXiv
Year: 2024
Subjects: subject: Spectral Theory (math.SP)
subject: Mathematical Physics (math-ph)
subject: Analysis of PDEs (math.AP)
subject: Quantum Physics (quant-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We consider Dirac operators on the half-line, subject to generalised infinite-mass boundary conditions. We derive sufficient conditions which guarantee the stability of the spectrum against possibly non-self-adjoint potential perturbations and study the optimality of the obtained results. Finally, we establish a non-relativistic limit which makes a relationship of the present model to the Robin Laplacian on the half-line.
description: 17 pages, 1 figure
title: Personality traits and meat consumption: the mediating role of animal-related ethical concerns
Creators: name: Haefner, Gonzalo
name: Schobin, Janosch
name: Risius, Antje
Publisher: name: Universität Kassel
Year: 2023
Subjects: subject: animal ethical concerns
subject: differential meat consumption
subject: personality traits
subject: animal ethics and welfare
subject: big five personality
subject: 150
subject: Tierethik
subject: Fleischverbrauch
subject: Verhaltensmuster
subject: Hypothese
subject: Persönlichkeitsfaktor

description: Gefördert durch den Publikationsfonds der Universität Kassel
Power-law Defect Energy in a Single-Crystal Gradient Plasticity Framework - A Computational Study
Creators: name: Bayerschen, E.
name: Böhlke, T.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computational Physics (physics.comp-ph)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: A single-crystal gradient plasticity model is presented that includes a power-law type defect energy depending on the gradient of an equivalent plastic strain. Numerical regularization for the case of vanishing gradients is employed in the finite element discretization of the theory. Three exemplary choices of the defect energy exponent are compared in finite element simulations of elastic-plastic tricrystals under tensile loading. The influence of the power-law exponent is discussed related to the distribution of gradients and in regard to size effects. In addition, an analytical solution is presented for the single slip case supporting the numerical results. The influence of the power-law exponent is contrasted to the influence of the normalization constant.
Efficient Transmission of Mixed Plasmodium falciparum/vivax Infections From Humans to Mosquitoes
Creators: name: Lin, Feng-Chang
name: Saunders, David l.
name: Lanteri, Charlotte
name: Balasubramanian, Sujata
name: My, Mok
name: Meshnick, Steven R.
name: Hathaway, Nicholas
name: Parobek, Christian
name: Vy, Dav
name: Lin, Jessica T.
name: Kuntawunginn, Worachet
name: Spring, Michele
name: Ubalee, Ratawan
name: Lon, Chanthap
name: Rahman, Rifat S.
name: Juliano, Jonathan J.
name: Saxe, Jeremy
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: BACKGROUND: In Southeast Asia, people are often coinfected with different species of malaria (Plasmodium falciparum [Pf] and Plasmodium vivax [Pv]) as well as with multiple clones of the same species. Whether particular species or clones within mixed infections are more readily transmitted to mosquitoes remains unknown. METHODS: Laboratory-reared Anopheles dirus were fed on blood from 119 Pf-infected Cambodian adults, with 5950 dissected to evaluate for transmitted infection. Among 12 persons who infected mosquitoes, polymerase chain reaction and amplicon deep sequencing were used to track species and clone-specific transmission to mosquitoes. RESULTS: Seven of 12 persons that infected mosquitoes harbored mixed Pf/Pv infection. Among these 7 persons, all transmitted Pv with 2 transmitting both Pf and Pv, leading to Pf/Pv coinfection in 21% of infected mosquitoes. Up to 4 clones of each species were detected within persons. Shifts in clone frequency were detected during transmission. However, in general, all parasite clones in humans were transmitted to mosquitoes, with individual mosquitoes frequently carrying multiple transmitted clones. CONCLUSIONS: Malaria diversity in human hosts was maintained in the parasite populations recovered from mosquitoes fed on their blood. However, in persons with mixed Pf/Pv malaria, Pv appears to be transmitted more readily, in association with more prevalent patent gametocytemia.
Treatment of esophageal leakages with the Microtech®-VAC-Stent : a monocentric early experience of three cases
Creators: name: Klose, Michelle A.
name: Walldorf, Jens
name: Damm, Marko
name: Krug, Sebastian
name: Klose, Johannes
name: Ronellenfitsch, Ulrich
name: Kleeff, Jörg H.
name: Michl, Patrick
name: Rosendahl, Jonas
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2023
Subjects: subject: 610

description: Background: Endoscopic approaches in the treatment of transmural esophageal defects, either after esophageal resection or due to perforation, have demonstrated convincing feasibility. Surgical options are limited and associated with high morbidity and mortality rates. Currently, internal endoscopic drainage with pigtail stents, self-expanding metal stent (SEMS), or endoscopic vacuum therapy (EVT) are options for first-line treatment. Here, we report the outcome of the recently developed combination of SEMS and EVT using the endoscopic Microtech®-VAC-Stent (EVS). Methods: Between June and July 2022, three consecutive patients (one female and two males) with esophageal transmural defects were treated with the Microtech®-VAC-Stent. Two patients suffered from an anastomotic leak after oncologic gastroesophageal surgery, and one patient presented with esophageal perforation due to Boerhaave syndrome. Results: Three consecutive patients were successfully treated with EVS. In one patient, one EVS treatment was sufficient, whereas the other two patients needed two and six EVS exchanges. Exchanges were scheduled every 7 days and no procedural adverse events were observed. Conclusion: In line with the former case series, EVS therapy is a promising new approach for the treatment of esophageal leaks. Exchange of the EVS seems feasible every 7 days reducing interventions for the individual patient. Prospective studies comparing EVS with other endoscopic therapies are needed to define the best therapeutic approach.
On the Physical Nature of the Source of Ultraluminous X-ray Pulsations
Creators: name: Ter-Kazarian, G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: To reconcile the observed unusual high luminosity of NuSTAR X-ray pulsations from M82X-2 with the most extreme violation of the Eddington limit, and in view that the persistent X-ray radiation from M82X-2 almost precludes the possibility of common pulsars, we tackle the problem by the implications of {\em microscopic theory of black hole} (MTBH). The preceding developments of MTBH are proved to be quite fruitful for the physics of ultra-high energy (UHE) cosmic-rays. Namely, replacing a central singularity by the infrastructures inside event horizon, subject to certain rules, MTBH explains the origin of ZeV-neutrinos which are of vital interest for the source of UHE-particles. The M82X-2 is assumed to be a spinning intermediate mass black hole resided in final stage of growth. As a corollary, the thermal blackbody X-ray emission arisen due to the rotational kinetic energy of black hole escapes from event horizon through the vista to outside world that detected as ultraluminous X-ray pulsations. The M82X-2 indeed releases $\sim 99.6\%$ of its pulsed radiative energy predominantly in the X-ray bandpass $0.3-30$ keV. We derive a pulse profile and give a quantitative account of energetics and orbital parameters of the semi-detached X-ray binary containing a primary accretor M82X-2 of inferred mass $M\simeq 138.5-226\,M_{\odot}$ and secondary massive, $M_{2}> 48.3- 64.9\,M_{\odot}$, O/B-type donor star with radius of $R> 22.1- 25.7\,R_{\odot}$, respectively. We compute the torque added to M82X-2 per unit mass of accreted matter which yields the measured spin-up rate.
description: Extended and revised version, which will appear in Astrophysics and Space Science (ASTR-D-15-00411R2-accepted). arXiv admin note: text overlap with arXiv:1109.1610, arXiv:1501.03180 by other authors
(103841) Susan Anne Stone
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Non-thermal melting of Neel order in the Hubbard model
Creators: name: Balzer, Karsten
name: Wolf, F. Alexander
name: McCulloch, Ian P.
name: Werner, Philipp
name: Eckstein, Martin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We study the unitary time evolution of antiferromagnetic order in the Hubbard model after a quench starting from the perfect Néel state. In this setup, which is well suited for experiments with cold atoms, one can distinguish fundamentally different pathways for melting of long-range order at weak and strong interaction. In the Mott insulating regime, melting of long-range order occurs due to the ultra-fast transfer of energy from charge excitations to the spin background, while local magnetic moments and their exchange coupling persist during the process. The latter can be demonstrated by a local spin-precession experiment. At weak interaction, local moments decay along with the long-range order. The dynamics is governed by residual quasiparticles, which are reflected in oscillations of the off-diagonal components of the momentum distribution. Such oscillations provide an alternative route to study the prethermalization phenomenon and its influence on the dynamics away from the integrable (noninteracting) limit. The Hubbard model is solved within nonequilibrium dynamical mean-field theory, using the density matrix-renormalization group as an impurity solver.
description: 11 pages
Collisions of Random Walks in Reversible Random Graphs
Creators: name: Hutchcroft, Tom
name: Peres, Yuval
Publisher: name: arXiv
Year: 2015
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: We prove that in any recurrent reversible random rooted graph, two independent simple random walks started at the same vertex collide infinitely often almost surely. This applies to the Uniform Infinite Planar Triangulation and Quadrangulation and to the Incipient Infinite Cluster in $\mathbb{Z}^2$.
description: 7 pages
Non-falciparum Malaria in Africa and Learning From Plasmodium vivax in Asia
Creators: name: Lin, Jessica T.
name: Parr, Jonathan B.
name: Ngasala, Billy
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: To the Editor—We read with interest Groger and colleagues’ prospective study of Plasmodium ovale relapses in Gabon [1]. Their work is timely given non-falciparum malaria’s increasing prom-inence in Africa and the potential role of hypnozoite-induced relapses in this trend. Despite declines in Plasmodium falciparum transmission, molecular sur-veys have shown a 6-fold increase in the odds of P.  ovale infection in Tanzania from 2010 to 2016 [2], and a similar trend in the Democratic Republic of Congo, where the species’ prevalence increased from 0.4 to 8.3% in national surveys con-ducted in 2007 and 2013 [3, 4]. Successful interventions against P.  falciparum in Zanzibar [5] and Uganda [6] have not had the same effect on non-falciparum species. Clearly, P.  ovale is becoming an increasingly important malaria in Africa.
title: A Blueprint for the Fourth Generation of Bank of Canada Projection and Policy Analysis Models
Creators: name: Coletti, Donald
Publisher: name: Bank of Canada
Year: 2023

description: This paper outlines a strategic plan for the development of the fourth generation of Bank of Canada projection and policy analysis models. The plan features a new Canadian workhorse macroeconomic model as well as a suite of alternative models to better support a risk management approach to monetary policy. This new generation of models seeks to improve our understanding of inflation dynamics, the supply side of the economy and the underlying risks faced by policy-makers coming from uncertainty about how the economy functions. New approaches for dealing with idiosyncratic trends in the data and for leveraging the power of large data sets will be employed.
description: Nous présentons ici un plan stratégique pour la conception de la quatrième génération de modèles utilisés par la Banque du Canada pour effectuer des projections et des analyses. Le plan décrit un nouveau modèle macroéconomique canadien de référence et un ensemble d’autres modèles. Le but de cette démarche est d’améliorer l’intégration de la gestion des risques dans la conduite de la politique monétaire. Cette nouvelle génération de modèles est destinée à approfondir notre compréhension de la dynamique de l’inflation, de l’offre au sein de l’économie et des risques sous-jacents auxquels sont confrontés les décideurs publics, causés par l’incertitude qui entoure le fonctionnement de l’économie. Il est prévu que de nouvelles méthodes soient utilisées pour composer avec les tendances idiosyncrasiques présentes dans les données et exploiter la puissance associée à la taille des vastes ensembles de données.
Relapse or reinfection: Classification of malaria infection using transition likelihoods
Creators: name: Lin, Feng-Chang
name: Li, Quefeng
name: Lin, Jessica T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2020

description: In patients with Plasmodium vivax malaria treated with effective blood-stage therapy, the recurrent illness may occur due to relapse from latent liver-stage infection or reinfection from a new mosquito bite. Classification of the recurrent infection as either relapse or reinfection is critical when evaluating the efficacy of an anti-relapse treatment. Although one can use whether a shared genetic variant exists between baseline and recurrence genotypes to classify the outcome, little has been suggested to use both sharing and nonsharing variants to improve the classification accuracy. In this paper, we develop a novel classification criterion that utilizes transition likelihoods to distinguish relapse from reinfection. When tested in extensive simulation experiments with known outcomes, our classifier has superior operating characteristics. A real data set from 78 Cambodian P. vivax malaria patients was analyzed to demonstrate the practical use of our proposed method.
(103843) George Edward Symonds
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Atovaquone-Proguanil in Combination with Artesunate to Treat Multidrug-Resistant P. falciparum Malaria in Cambodia: An Open-Label Randomized Trial
Creators: name: Lek, Dysoley
name: Heang, Vireak
name: Kong, Nareth
name: Spring, Michele
name: Saunders, David
name: Smith, Philip
name: Gosi, Panita
name: Berjohn, Catherine M.
name: Chum, Bolin
name: Sok, Somethy
name: Rachmat, Agus
name: Chaoratanakawee, Suwanna
name: Lin, Jessica
name: Ittiverakul, Mali
name: Waltmann, Andreea
name: Heng, Thay Keang
name: Vaughn, Andrew
name: Buathong, Nillawan
name: Vanachayangkul, Pattaraporn
name: Chann, Soklyda
name: Luntawunginn, Worachet
name: Burkly, Hana
name: Wongarunkochakorn, Saowaluk
name: Prom, Satharath
name: Lon, Chanthap
name: Boonchan, Threechada
name: Harrison, Dustin
name: Wojarnarski, Mariusz
name: Fukuda, Mark M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2019

description: Background: Recent artemisinin-combination therapy failures in Cambodia prompted a search for alternatives. Atovaquone-proguanil (AP), a safe, effective treatment for multidrug-resistant Plasmodium falciparum (P.f.), previously demonstrated additive effects in combination with artesunate (AS). Methods: Patients with P.f. or mixed-species infection (n = 205) in Anlong Veng (AV; n = 157) and Kratie (KT; n = 48), Cambodia, were randomized open-label 1:1 to a fixed-dose 3-day AP regimen +/-3 days of co-administered artesunate (ASAP). Single low-dose primaquine (PQ, 15 mg) was given on day 1 to prevent gametocyte-mediated transmission. Results: Polymerase chain reaction-adjusted adequate clinical and parasitological response at 42 days was 90% for AP (95% confidence interval [CI], 82%-95%) and 92% for ASAP (95% CI, 83%-96%; P =. 73). The median parasite clearance time was 72 hours for ASAP in AV vs 56 hours in KT (P <. 001) and was no different than AP alone. At 1 week postprimaquine, 7% of the ASAP group carried microscopic gametocytes vs 29% for AP alone (P =. 0001). Nearly all P.f. isolates had C580Y K13 propeller artemisinin resistance mutations (AV 99%; KT 88%). Only 1 of 14 treatment failures carried the cytochrome bc1 (Pfcytb) atovaquone resistance mutation, which was not present at baseline. P.f. isolates remained atovaquone sensitive in vitro but cycloguanil resistant, with a triple P.f. dihydrofolate reductase mutation. Conclusions: Atovaquone-proguanil remained marginally effective in Cambodia (≥90%) with minimal Pfcytb mutations observed. Treatment failures in the presence of ex vivo atovaquone sensitivity and adequate plasma levels may be attributable to cycloguanil and/or artemisinin resistance. Artesunate co-administration provided little additional blood-stage efficacy but reduced post-treatment gametocyte carriage in combination with AP beyond single low-dose primaquine.
Invisible but Significant: Increasing Awareness for Seagrass Protection
Creators: name: Brewer, Abigail
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2019
Subjects: Atlantic Ocean--Bogue Sound
Estuarine restoration
Seagrasses
Conservation of natural resources -- Public relations
Social marketing

description: Submerged Aquatic Vegetation (SAV), more commonly known as seagrass, is a flowering plant that lives submerged under shallow coastal waters. North Carolina is home to more seagrass than all other east coast states combined, except for Florida. The plant is a living resource, taking pollutants and sediments out of the water and providing a habitat for fish, shellfish, and tiny invertebrates. The Albemarle-Pamlico National Estuary Partnership’s SAV Action Team works to protect and restore seagrass in the Albemarle-Pamlico region. In summer 2018, the team became interested in increasing public awareness of this living resource. The first step in creating an awareness campaign was a content analysis of environmental campaign posters. Interviews with scientists and fishers living in the southern Albemarle-Pamlico region informed journalistic pieces to be used in the awareness campaign. These things were combined into a communications plan, complete with a messaging strategy, social media plan, and written content.
Stochastic Gravitational Wave Background from Exoplanets
Creators: name: Ain, Anirban
name: Kastha, Shilpa
name: Mitra, Sanjit
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: Recent exoplanet surveys have predicted a very large population of planetary systems in our galaxy, more than one planet per star on the average, perhaps totalling about two hundred billion. These surveys, based on electro-magnetic observations, are limited to a very small neighbourhood of the solar system and the estimations rely on the observations of only a few thousand planets. On the other hand, orbital motions of planets around stars are expected to emit gravitational waves (GW), which could provide information about the planets not accessible to electro-magnetic astronomy. The cumulative effect of the planets, with periods ranging from few hours to several years, is expected to create a stochastic GW background (SGWB). We compute the characteristic GW strain of this background based on the observed distribution of planet parameters. We also show that the integrated extragalactic background is comparable or less than the galactic background at different frequencies. Our estimate shows that the net background is significantly below the sensitivities of the proposed GW experiments in different frequency bands. However, we notice that the peak of the spectrum, at around $10^{-5}$Hz, is not too far below the proposed space based GW missions. A future space based mission may be able to observe or tightly constrain this signal, which will possibly be the only way to probe the galactic population of exoplanets as a whole.
description: 7 pages, 2 figures
Ultraslow calorimetric studies of the martensitic transformation of NiFeGa alloys: detection and analysis of avalanche phenomena
Creators: name: Martín-Olalla, José-María
name: Vidal-Crespo, Antonio
name: Manchón-Gordón, Alejandro F.
name: Romero, Francisco Javier
name: Blázquez, Javier S.
name: Gallardo, María Carmen
name: Conde, Clara F.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We study the thermal properties of a bulk Ni55Fe19Ga26 Heusler alloy in a conduction calorimeter. At slow heating and cooling rates (1K/h), we compare as-cast and annealed samples. We report a smaller thermal hysteresis after the thermal treatment due to the stabilization of the 14M modulated structure in the martensite phase. In ultraslow experiments (40mK/h), we detect and analyze the calorimetric avalanches associated with the direct and reverse martensitic transformation from cubic to 14M phase. This reveals a distribution of events characterized by a power law with exponential cutoff $p(u) \propto u^{-\varepsilon}\exp(-u/ξ)$ where $\varepsilon\sim 2$ and damping energies $ξ=370$uJ (direct) and $ξ=27$uJ (reverse) that characterize the asymmetry of the transformation.
description: 13 pages; 6 figures; 3 tables
title: Towards a unified multiphysics framework applied to reactive bubbly flows
Creators: name: Habes, Constantin
Publisher: name: UNSPECIFIED
Year: 2023

description: Historically, CFD codes implementing arbitrary Lagrangian Eulerian interface tracking (ALEIT) for the simulation of bubbly flows were highly customised for this specific application. However, taking a broader look at multiphase flows in general, it is noticeable that they resemble other multiphysics systems in their basic structure. Analogous to Fluid-Structure-Interaction (FSI) or conjugate heat transfer problems (CHT), multiphase systems also involve several regions with special physical properties that interact with each other across interfaces. Exploiting these structural similarities, a novel unified multiphysics framework for OpenFOAM named multiRegionFoam is introduced, which incorporates the ALE-IT and is tested for its application towards reactive bubbly flows. In this context, the parallelisability of the new framework is addressed in particular, since interface coupled multiphysics simulations in general and simulations of reactive bubbly flows in particular are very computationally intensive. Furthermore, a Dirichlet-Neumann algorithm convergence control based on interface residuals is implemented and tested.
(103844) Frederick Symonds
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Universality of Vibrational Spectra of Globular Proteins
Creators: name: Na, Hyuntae
name: Song, Guang
name: ben-Avraham, Daniel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Biomolecules (q-bio.BM)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: It is shown that the density of modes of the vibrational spectrum of globular proteins is universal, i.e., regardless of the protein in question it closely follows one universal curve. The present study, including 135 proteins analyzed with a full atomic empirical potential (CHARMM22) and using the full complement of all atoms Cartesian degrees of freedom, goes far beyond previous claims of universality, confirming that universality holds even in the high-frequency range (300- 4000 1/cm), where peaks and turns in the density of states are faithfully reproduced from one protein to the next. We also characterize fluctuations of the spectral density from the average, paving the way to a meaningful discussion of rare, unusual spectra and the structural reasons for the deviations in such "outlier" proteins. Since the method used for the derivation of the vibrational modes (potential energy formulation, set of degrees of freedom employed, etc.) has a dramatic effect on the spectral density, another significant implication of our findings is that the universality can provide an exquisite tool for assessing and improving the quality of various models used for NMA computations. Finally, we show that the input configuration too affects the density of modes, thus emphasizing the importance of simplified potential energy formulations that are minimized at the outset.
Stability of solutions to stochastic partial differential equations
Creators: name: Gess, Benjamin
name: Tölle, Jonas M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Analysis of PDEs (math.AP)
subject: Probability (math.PR)
subject: FOS: Mathematics
subject: Primary: 35K55, 35K92, 60H15, Secondary: 37L15, 45E10, 49J45

description: We provide a general framework for the stability of solutions to stochastic partial differential equations with respect to perturbations of the drift. More precisely, we consider stochastic partial differential equations with drift given as the subdifferential of a convex function and prove continuous dependence of the solutions with regard to random Mosco convergence of the convex potentials. In particular, we identify the concept of stochastic variational inequalities (SVI) as a well-suited framework to study such stability properties. The generality of the developed framework is then laid out by deducing Trotter type and homogenization results for stochastic fast diffusion and stochastic singular p-Laplace equations. In addition, we provide an SVI treatment for stochastic nonlocal p-Laplace equations and prove their convergence to the respective local models.
description: 39 pages, to appear in: J. Differential Equations