title: Effects of Medium-Chain Triglycerides on Cognitive Impairments in Adult Female Wistar Rats in a Model of Neonatal Inflammation
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: ÐÐ»Ð¸ÑÐ½Ð¸Ðµ ÑÑÐµÐ´Ð½ÐµÑÐµÐ¿Ð¾ÑÐµÑÐ½ÑÑ ÑÑÐ¸Ð³Ð»Ð¸ÑÐµÑÐ¸Ð´Ð¾Ð² Ð½Ð° ÐºÐ¾Ð³Ð½Ð¸ÑÐ¸Ð²Ð½ÑÐµ Ð½Ð°ÑÑÑÐµÐ½Ð¸Ñ Ð²Ð·ÑÐ¾ÑÐ»ÑÑ ÑÐ°Ð¼Ð¾Ðº ÐºÑÑÑ ÐÐ¸ÑÑÐ°Ñ Ð² Ð¼Ð¾Ð´ÐµÐ»Ð¸ Ð½ÐµÐ¾Ð½Ð°ÑÐ°Ð»ÑÐ½Ð¾Ð³Ð¾ Ð²Ð¾ÑÐ¿Ð°Ð»ÐµÐ½Ð¸Ñ
Creators: name: Ð¨Ð¸ÑÐ¾ÐºÐ¾Ð², ÐÐ³Ð¾Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: ÐÐ¸Ð¾ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸Ñ
capric acid
caprylic acid
inflammation
ketosis
cognitive impairment
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ÐºÐ°Ð¿ÑÐ¸Ð»Ð¾Ð²Ð°Ñ ÐºÐ¸ÑÐ»Ð¾ÑÐ°
Ð²Ð¾ÑÐ¿Ð°Ð»ÐµÐ½Ð¸Ðµ
ÐºÐµÑÐ¾Ð·
ÐºÐ¾Ð³Ð½Ð¸ÑÐ¸Ð²Ð½ÑÐµ Ð½Ð°ÑÑÑÐµÐ½Ð¸Ñ

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description: The given work is devoted to investigation of the effects of supplementation of diet with medium-chain triglycerides (MCT) on cognitive impairments in adult female Wistar rats in a model of neonatal inflammation. Neonatal inflammation was modeled by administration of LPS (25 Âµg/kg) during third week of postnatal development. Adult animals received 3 g/kg of MCT oil (C8 + C10) for 28 days. Working memory was assessed in Y-maze test, locomotor activity, anxiety-like and exploratory behaviors were assessed in Open Field test, while spatial memory was assessed in Morris Water Maze test. In order to investigate possible mechanisms underlying the effects of experimental interventions, blood serum levels of Î²hydroxybutyrate (Î²HB) were analyzed, as well as relative expression levels in dorsal hippocampus of neuroplasticity genes, and genes encoding for brain glutamatergic system. Ultimately, neither early postnatal LPS administration, nor MCT supplementation, nor interaction of these interventions resulted in significant effects on female Wistar ratsâ behavior, or on the expression profile of examined genes related to brain functions. Levels of Î²HB were increased 30 and 60 minutes after MCT supplementation, but not after that time. Together with the available data on similar experiments, these results indicate the possibility of gender-specific effects of LPS-induced inflammation and MCT supplementation.