cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Hamiltonian replica-exchange in GROMACS: a flexible implementation
Creators: name: Bussi, Giovanni
Publisher: name: arXiv
Year: 2013
Subjects: subject: Computational Physics (physics.comp-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Biological Physics (physics.bio-ph)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: A simple and general implementation of Hamiltonian replica exchange for the popular molecular-dynamics software GROMACS is presented. In this implementation, arbitrarily different Hamiltonians can be used for the different replicas without incurring in any significant performance penalty. The implementation was validated on a simple toy model - alanine dipeptide in water - and applied to study the rearrangement of an RNA tetraloop, where it was used to compare recently proposed force-field corrections.
description: To appear on Molecular Physics
Dasyprocta Illiger 1811
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Dasyproctidae
Dasyprocta

description: Dasyprocta Illiger, 1811. Prodr. Syst. Mamm. et Avium., p. 93. ISIS NUMBER: 5301410022003000000.
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Rodentia (Part 6), pp. 560-594 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 576, DOI: 10.5281/zenodo.7353039
Coroutining Folds with Hyperfunctions
Creators: name: Launchbury, J.
name: Krstic, S.
name: Sauerwein, T. E.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Programming Languages (cs.PL)
subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences
subject: D.1.1

description: Fold functions are a general mechanism for computing over recursive data structures. First-order folds compute results bottom-up. With higher-order folds, computations that inherit attributes from above can also be expressed. In this paper, we explore folds over a form of recursive higher-order function, called hyperfunctions, and show that hyperfunctions allow fold computations to coroutine across data structures, as well as compute bottom up and top down. We use the compiler technique of foldr-build as an exemplar to show how hyperfunctions can be used.
description: In Proceedings Festschrift for Dave Schmidt, arXiv:1309.4557. It is a privilege to submit a paper for the Festschrift symposium held to honor Dave Schmidt's lifetime of contributions on the occasion of his 60th birthday. Many years ago, as a fresh PhD student, Dave's excellent book on Denotational Semantics opened my eyes to rich possibilities of building functions over functions (recursively!) and our continued interactions over the years were always insightful. So it seemed appropriate to offer a paper whose foundations rely on the same mathematical models that Dave so ably expounded all those years ago, constructing recursive function spaces in a way that is not possible in traditional set-theoretic models. -- John Launchbury, 2013
Association of Cross-Reactive Antibodies Targeting Peptidyl-Arginine Deiminase 3 and 4 with Rheumatoid Arthritis-Associated Interstitial Lung Disease
Creators: name: Giles, Jon T.
name: Darrah, Erika
name: Danoff, Sonye
name: Johnson, Cheilonda
name: Andrade, Felipe
name: Rosen, Antony
name: Bathon, Joan M.
Publisher: name: Columbia University
Year: 2014
Subjects: Rheumatoid arthritis--Patients
Interstitial lung diseases
Rheumatology
Ornithine carbamoyltransferase
Molecular biology
Pathology
Medicine

description: Background:

A subset of rheumatoid arthritis (RA) patients have detectable antibodies directed against the peptidyl-arginine deiminase (PAD) enzyme isoforms 3 and 4. Anti-PAD3/4 cross-reactive antibodies (anti-PAD3/4XR) have been shown to lower the calcium threshold required for PAD4 activation, an effect potentially relevant to the pathogenesis of RA-associated interstitial lung disease (ILD).

Methods:

RA patients underwent multi-detector computed tomography (MDCT) of the chest with interpretation by a pulmonary radiologist for ILD features. A semi-quantitative ILD Score (range 0–32) was calculated. Concurrent serum samples were assessed for antibodies against PAD by immunoprecipitation with radiolabeled PAD3 and PAD4.

Results:

Among the 176 RA patients studied, any ILD was observed in 58 (33%) and anti-PAD3/4XR was detected in 19 (11%). The frequency of any ILD among those with anti-PAD3/4XR was 68% vs. 29% among those with no anti-PAD (crude OR = 5.39; p = 0.002) and vs. 27% among those with anti-PAD4 that was not cross-reactive with PAD3 (crude OR = 5.74; p = 0.001). Both associations were stronger after adjustment for relevant confounders (adjusted ORs = 7.22 and 6.61, respectively; both p-values<0.01). Among ever smokers with anti-PAD3/4XR, the adjusted frequency of any ILD was 93% vs. 17% for never smokers without the antibody (adjusted OR = 61.4; p = 0.001, p-value for the interaction of smoking with anti-PAD3/4XR<0.05).

Conclusions:

The prevalence and extent of ILD was markedly higher among RA patients with anti-PAD3/4 cross-reactive antibodies, even after accounting for relevant confounders, particularly among ever smokers. These findings may suggest etiopathologic mechanisms of RA-ILD, and their clinical utility for predicting ILD warrants additional study.
Integrating water and insect pest management in agriculture
Creators: name: Lin, Po-An
name: Paudel, Sulav
name: Lai, Pin-Chu
name: GC, Raj K.
name: Yang, Dan-Hong
name: Felton, Gary
Publisher: name: AgResearch
Year: 2023
Subjects: classificationCode: 300409
subject: Crop and pasture protection (incl. pests, diseases and weeds)

description: Water and herbivory are two of the most crucial factors limiting plant growth, and their management is a critical part of crop production. However, due to climate change, the management of water and pests has become increasingly challenging. Although increasing evidence has suggested strong interactions among water, plants, and insects, the level to which water and insect pest management can be integrated is largely unexplored. This review summarizes and synthesizes current knowledge on the ecology of water-plant-insect interactions and agricultural practices that integrate water management rationale in pest management. We further discuss the importance of these agricultural practices under the context of farming types and regional differences at a global scale. A better understanding of the interactions between water and pest management will likely increase synergism and prevent antagonism among different management practices. The review informs future studies on integrating water and pest management and highlights current knowledge gaps that are essential for integrating water and pest management. We aim to facilitate the development of management strategies that enhance plant stress resilience and agricultural sustainability.
Dasyprocta azarae Lichtenstein 1823
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Dasyproctidae
Dasyprocta
Dasyprocta azarae

description: Dasyprocta azarae Lichtenstein, 1823. Verz. Doublet. Zool. Mus. Berlin, p. 3. TYPE LOCALITY: Brazil, Sao Paulo. DISTRIBUTION: E.C. and S. Brazil; Paraguay; N.E. Argentina. ISIS NUMBER: 5301410022003004001.
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Rodentia (Part 6), pp. 560-594 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 576, DOI: 10.5281/zenodo.7353039
Changes in QTc Interval in the Citalopram for Agitation in Alzheimer's Disease (CitAD) Randomized Trial
Creators: name: Drye, Lea T.
name: Spragg, David
name: Devanand, Devangere P.
name: Frangakis, Constantine
name: Marano, Christopher
name: Meinert, Curtis L.
name: Mintzer, Jacobo E.
name: Munro, Cynthia A.
name: Pelton, Gregory
name: Pollock, Bruce G.
name: Porsteinsson, Anton P.
name: Rabins, Peter V.
name: Rosenberg, Paul B.
name: Schneider, Lon S.
name: Shade, David M.
name: Weintraub, Daniel
name: Yesavage, Jerome
name: Lyketsos, Constantine G.
name: CitAD Research Group
Publisher: name: Columbia University
Year: 2014
Subjects: subject: Long QT syndrome
subject: Serotonin uptake inhibitors
subject: Clinical trials
subject: Alzheimer's disease--Patients
subject: Neurosciences
subject: FOS: Clinical medicine
subject: Medicine

description: Background:

A Food and Drug Administration (FDA) safety communication in August 2011 warned that citalopram was associated with a dose dependent risk of QT prolongation and recommended dose restriction in patients over the age of 60 but did not provide data for this age group.

Methods:

CitAD was a randomized, double-masked, placebo-controlled, multicenter clinical trial for agitation in Alzheimer's disease (AD). Participants were assigned to citalopram (target dose of 30 mg/day) or placebo in a 1∶1 ratio. 186 people, 181 of whom were over the age of 60, having probable AD with clinically significant agitation were recruited from September 2009 to January 2013. After the FDA safety communication about citalopram, ECG was added to the required study procedures before enrollment and repeated at week 3 to monitor change in QTc interval. Forty-eight participants were enrolled after enhanced monitoring began.

Results:

Citalopram treatment was associated with a larger increase in QTc interval than placebo (difference in week 3 QTc adjusting for baseline QTc: 18.1 ms [95% CI: 6.1, 30.1]; p = 0.004). More participants in the citalopram group had an increase ≥30 ms from baseline to week 3 (7 in citalopram versus 1 in placebo; Fisher's exact p = 0.046), but only slightly more in the citalopram group met a gender-specific threshold for prolonged QTc (450 ms for males; 470 ms for females) at any point during follow-up (3 in citalopram versus 1 in placebo, Fisher's exact p = 0.611). One of the citalopram participants who developed prolonged QTc also displayed ventricular bigeminy. No participants in either group had a cardiovascular-related death.

Conclusion:

Citalopram at 30 mg/day was associated with improvement in agitation in patients with AD but was also associated with QT prolongation.
Topological phase transition in a discrete quasicrystal
Creators: name: Sagi, Eran
name: Eisenberg, Eli
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We investigate a two-dimensional tiling model. Even though the degrees of freedom in this model are discrete, it has a hidden continuous global symmetry in the infinite lattice limit, whose corresponding Goldstone modes are the quasicrystalline phasonic degrees of freedom. We show that due to this continuous symmetry, and despite the apparent discrete nature of the model, a topological phase transition from a quasi-long-range ordered to a disordered phase occurs at a finite temperature, driven by vortex proliferation. We argue that some of the results are universal properties of two-dimensional systems whose ground state is a quasicrystalline state.
Dasyprocta coibae Thomas 1902
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Dasyproctidae
Dasyprocta
Dasyprocta coibae

description: Dasyprocta coibae Thomas, 1902. Novit. Zool., 9:136. TYPE LOCALITY: Panama, Coiba Isl. DISTRIBUTION: Coiba Isl. (Panama). COMMENT: Reviewed by Hall, 1981:862. ISIS NUMBER: 5301410022003005001.
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Rodentia (Part 6), pp. 560-594 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 576, DOI: 10.5281/zenodo.7353039
description: {"references": ["Hall, E. R. 1981. The mammals of North America. Second ed. John Wiley and Sons, New York, 1: 1 - 600 + 90, 2: 601 - 1181 + 90."]}
Kernel Multivariate Analysis Framework for Supervised Subspace Learning: A Tutorial on Linear and Kernel Multivariate Methods
Creators: name: Arenas-García, Jerónimo
name: Petersen, Kaare Brandt
name: Camps-Valls, Gustavo
name: Hansen, Lars Kai
Publisher: name: arXiv
Year: 2013
Subjects: subject: Machine Learning (stat.ML)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Feature extraction and dimensionality reduction are important tasks in many fields of science dealing with signal processing and analysis. The relevance of these techniques is increasing as current sensory devices are developed with ever higher resolution, and problems involving multimodal data sources become more common. A plethora of feature extraction methods are available in the literature collectively grouped under the field of Multivariate Analysis (MVA). This paper provides a uniform treatment of several methods: Principal Component Analysis (PCA), Partial Least Squares (PLS), Canonical Correlation Analysis (CCA) and Orthonormalized PLS (OPLS), as well as their non-linear extensions derived by means of the theory of reproducing kernel Hilbert spaces. We also review their connections to other methods for classification and statistical dependence estimation, and introduce some recent developments to deal with the extreme cases of large-scale and low-sized problems. To illustrate the wide applicability of these methods in both classification and regression problems, we analyze their performance in a benchmark of publicly available data sets, and pay special attention to specific real applications involving audio processing for music genre prediction and hyperspectral satellite images for Earth and climate monitoring.
Efficient estimation of error bounds for quantum multiparametric imaging with constraints
Creators: name: Mikhalychev, Alexander
name: Almazrouei, Saif
name: Mikhalycheva, Svetlana
name: Bouchalkha, Abdellatif
name: Mogilevtsev, Dmitri
name: Ahmedov, Bobomurat
Publisher: name: arXiv
Year: 2024
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Advanced super-resolution imaging techniques require specific approaches for accurate and consistent estimation of the achievable spatial resolution. Fisher information supplied to Cramer-Rao bound (CRB) has proved to be a powerful and efficient tool for resolution analysis and optical setups optimization. However, the standard CRB is not applicable to constrained problems violating the unbiasedness condition, while such models are frequently encountered in quantum imaging of complex objects. Complimentary to the existing approaches based on modifying CRB, we propose a practical algorithm for approximate construction of a modified Fisher information matrix, which takes the constraints into account and can be supplied to the standard CRB. We demonstrate the efficiency of the proposed technique by applying it to 1-, 2-, and multi-parameter model problems in quantum imaging. The approach provides quantitative explanation of previous results with successful experimental reconstruction of objects with the spatial scale smaller than the theoretical limit predicted by the standard CRB.
description: Accepted by Physical Review A (March 2025)
British Columbia Legislative Assembly sessional clipping book (1896-01)
Creators: name: :Unav
Publisher: name: University of Victoria Libraries
Year: 2022
Subjects: subject: Law
valueUri: http://id.worldcat.org/fast/993678
subject: FOS: Law
subject: Politics and government
valueUri: http://id.worldcat.org/fast/1919741
subject: British Columbia. Legislative Assembly
valueUri: http://id.worldcat.org/fast/600765

description: These Sessional Clippings books cover the period 1891 to 1972, and include newspaper accounts written by various legislative reporters who covered debates occurring in the British Columbia Legislative Assembly. Transcripts of debates of the Legislative Assembly (Hansard) were not published in B.C. until 1970; hence these "Sessional Clipping Books" augment the "Journals", the record of daily proceedings of the Legislative Assembly. Selected clippings from various newspapers including the Vancouver Sun, the Vancouver Province, the Colonist, and the Times newspapers, relating to the newspaper reports concerning activities of the Legislature. The original sessional clippings books comprise 351 ledger size print volumes, held at the Legislative Library in Victoria BC. The print volumes were microfilmed onto 26 reels in 1977 under a Tri University Libraries (TRIUL) project by Precision Micrographic Services (Vancouver, B.C.), with the permission of the Legislative Library, Victoria, British Columbia. This digital collection was created by scanning the 26 microfilm reels.
Characterization of Desmoglein Expression in the Normal Prostatic Gland. Desmoglein 2 Is an Independent Prognostic Factor for Aggressive Prostate Cancer
Creators: name: Barber, Alison G.
name: Castillo-Martin, Mireia
name: Bonal, Dennis M.
name: Rybicki, Benjamin A.
name: Christiano, Angela M.
name: Cordon-Cardo, Carlos
Publisher: name: Columbia University
Year: 2014
Subjects: Cadherins
Prostate
Desmosomes
Prostate--Cancer
Cytology
Oncology

description: Purpose:

The expression of desmogleins (DSGs), which are known to be crucial for establishing and maintaining the cell-cell adhesion required for tissue integrity, has been well characterized in the epidermis and hair follicle; however, their expression in other epithelial tissues such as prostate is poorly understood. Although downregulation of classical cadherins, such as E-cadherin, has been described in prostate cancer tissue samples, the expression of desmogleins has only been previously reported in prostate cancer cell lines. In this study we characterized desmoglein expression in normal prostate tissues, and further investigated whether Desmoglein 2 (DSG2) expression specifically can serve as a potential clinical prognostic factor for patients diagnosed with primary prostate cancer.

Experimental Design:

We utilized immunofluorescence to examine DSG2 expression in normal prostate (n = 50) and in a clinically well-characterized cohort of prostate cancer patients (n = 414). Correlation of DSG2 expression with clinico-pathological characteristics and biochemical recurrence was analyzed to assess its clinical significance.

Results:

These studies revealed that DSG2 and DSG4 were specifically expressed in prostatic luminal cells, whereas basal cells lack their expression. In contrast, DSG1 and DSG3 were not expressed in normal prostate epithelium. Further analyses of DSG2 expression in prostate cancer revealed that reduced levels of this biomarker were a significant independent marker of poor clinical outcome.

Conclusion:

Here we report for the first time that a low DSG2 expression phenotype is a useful prognostic biomarker of tumor aggressiveness and may serve as an aid in identifying patients with clinically significant prostate cancer.
Locating Bound Structure in an Accelerating Universe
Creators: name: Pearson, David W.
name: Batuski, David J.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Given the overwhelming evidence that the universe is currently undergoing an accelerated expansion, the question of what are the largest gravitationally bound structures remains. A couple of groups, Busha et al. 2003 (B03) and Dunner et al. 2006 (D06), have attempted to analytically define these limits, arriving at substantially different estimates due to differences in their assumptions about the velocities at the present epoch. In an effort to locate the largest bound structures in the universe, we selected the Aquarius (ASC), Microscopium (MSC), Corona Borealis (CBSC), and Shapley (SSC) superclusters for study, due to their high number density of rich Abell clusters. Simple N-body simulations, which assumed negligible intercluster mass, were used to assess the likelihood of these structures being gravitationally bound, and the predictions of the models of B03 and D06 were compared with those results. We find that ASC, and MSC contain pairs of clusters which are gravitationally bound, A2541/A2546 and A3695/A3696 respectively, with no other structures having a significant chance of being bound. For SSC, we find a group of five clusters, A3554, A3556, A3558, A3560, and A3562 that are bound, with an additional pair, A1736/A3559, having a slight chance of being bound. We find that CBSC has no extended bound structure, contrary to the findings of Small et al. 1998, who claim that the entire supercluster is bound. In regards to the analytical models, we find that B03 will identify structure that is definitely bound, but tends to underestimate the true extent of the structure, while D06 will identify all structure that is bound while overestimating its extent. Combined, the two models can provide lower and upper limits to the extent of bound structures so long as there are no other significant structures nearby or no significant dark matter exterior to the clusters.
Adaptation dynamics in densely clustered chemoreceptors
Creators: name: Pontius, William
name: Sneddon, Michael W.
name: Emonet, Thierry
Publisher: name: arXiv
Year: 2013
Subjects: subject: Molecular Networks (q-bio.MN)
subject: FOS: Biological sciences

description: In many sensory systems, transmembrane receptors are spatially organized in large clusters. Such arrangement may facilitate signal amplification and the integration of multiple stimuli. However, this organization likely also affects the kinetics of signaling since the cytoplasmic enzymes that modulate the activity of the receptors must localize to the cluster prior to receptor modification. Here we examine how these spatial considerations shape signaling dynamics at rest and in response to stimuli. As a model, we use the chemotaxis pathway of Escherichia coli, a canonical system for the study of how organisms sense, respond, and adapt to environmental stimuli. In bacterial chemotaxis, adaptation is mediated by two enzymes that localize to the clustered receptors and modulate their activity through methylation-demethylation. Using a novel stochastic simulation, we show that distributive receptor methylation is necessary for successful adaptation to stimulus and also leads to large fluctuations in receptor activity in the steady state. These fluctuations arise from noise in the number of localized enzymes combined with saturated modification kinetics between localized enzymes and receptor substrate. An analytical model explains how saturated enzyme kinetics and large fluctuations can coexist with an adapted state robust to variation in the expression level of the pathway constituents, a key requirement to ensure the functionality of individual cells within a population. This contrasts with the well-mixed covalent modification system studied by Goldbeter and Koshland in which mean activity becomes ultrasensitive to protein abundances when the enzymes operate at saturation. Large fluctuations in receptor activity have been quantified experimentally. Here we clarify their mechanistic relationship with well-studied aspects of the chemotaxis system, precise adaptation and functional robustness.
description: Pontius W, Sneddon MW, Emonet T (2013) Adaptation Dynamics in Densely Clustered Chemoreceptors. PLoS Comput Biol 9(9): e1003230. doi:10.1371/journal.pcbi.1003230
title: Principles of Psychological Assessment
title: With Applied Examples in R
titleType: Subtitle
Creators: name: Petersen, Isaac T
Publisher: name: University of Iowa Libraries
Year: 2024
Subjects: psychological assessment
measurement
reliability
validity
psychometrics
structural equation modeling
item response theory
factor analysis
generalizability theory
test bias
openhawks

description: Assessment is the gathering of information to improve decision-making. There are many approaches to psychological assessment that can be used to assess people’s thoughts, emotions, and behaviors, including self-report questionnaires, questionnaires reported by others, interviews, observations, biopsychological assessments, performance-based assessments, archival approaches, and combinations of these. However, the field has paid insufficient attention to measurement. There has been a proliferation of pseudoscience in assessment, including inaccurate assessments that can potentially cause harm. It is crucial to use assessments that are supported by science—with strong psychometric properties, including reliability and validity, and to develop better assessments.
description: This book discusses the principles of psychological assessment to help researchers and clinicians better develop, evaluate, administer, score, integrate, and interpret psychological assessments. It is intended for use by graduate students, faculty, researchers, and practicing psychologists. The book discusses psychometrics (reliability and validity), the assessment of various psychological domains (behavior, personality, intellectual functioning), various measurement methods (e.g., questionnaires, observations, interviews, biopsychological assessments, performance-based assessments), and emerging analytical frameworks to evaluate and improve assessment, including generalizability theory, structural equation modeling, item response theory, and signal detection theory. The book also discusses considerations of ethics, test bias, and cultural and individual diversity.
description: The book provides analysis examples using the free software, R, to help readers apply the principles to research and practice. The text, analysis code/syntax, R output, figures, and interpretation are all integrated to help guide readers. The book uses the freely available petersenlab package for R, which includes many functions relevant for assessment. The dissemination of these principles and tools will promote the development of more efficient and accurate assessment strategies that will lead to important scientific advancements and improved intervention.
Analyzing the Performance Portability of SYCL across CPUs, GPUs, and Hybrid Systems with SW Sequence Alignment
Creators: name: Costanzo, Manuel
name: Rucci, Enzo
name: García-Sánchez, Carlos
name: Naiouf, Marcelo
name: Prieto-Matías, Manuel
Publisher: name: arXiv
Year: 2024
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Computer and information sciences

description: The high-performance computing (HPC) landscape is undergoing rapid transformation, with an increasing emphasis on energy-efficient and heterogeneous computing environments. This comprehensive study extends our previous research on SYCL's performance portability by evaluating its effectiveness across a broader spectrum of computing architectures, including CPUs, GPUs, and hybrid CPU-GPU configurations from NVIDIA, Intel, and AMD. Our analysis covers single-GPU, multi-GPU, single-CPU, and CPU-GPU hybrid setups, using two common, bioinformatic applications as a case study. The results demonstrate SYCL's versatility across different architectures, maintaining comparable performance to CUDA on NVIDIA GPUs while achieving similar architectural efficiency rates on AMD and Intel GPUs in the majority of cases tested. SYCL also demonstrated remarkable versatility and effectiveness across CPUs from various manufacturers, including the latest hybrid architectures from Intel. Although SYCL showed excellent functional portability in hybrid CPU-GPU configurations, performance varied significantly based on specific hardware combinations. Some performance limitations were identified in multi-GPU and CPU-GPU configurations, primarily attributed to workload distribution strategies rather than SYCL-specific constraints. These findings position SYCL as a promising unified programming model for heterogeneous computing environments, particularly for bioinformatic applications.
description: arXiv admin note: text overlap with arXiv:2309.09609
Opposing Effects of α2- and β-Adrenergic Receptor Stimulation on Quiescent Neural Precursor Cell Activity and Adult Hippocampal Neurogenesis
Creators: name: Jhaveri, Dhanisha J.
name: Nanavaty, Ishira
name: Prosper, Boris W.
name: Marathe, Swanand
name: Husain, Basma F. A.
name: Kernie, Steven G.
name: Bartlett, Perry F.
name: Vaidya, Vidita A.
Publisher: name: Columbia University
Year: 2014
Subjects: subject: Alpha adrenoceptors
subject: Hippocampus (Brain)--Growth
subject: Developmental neurobiology
subject: Beta adrenoceptors
subject: Neurosciences
subject: FOS: Clinical medicine
subject: Cytology

description: Norepinephrine regulates latent neural stem cell activity and adult hippocampal neurogenesis, and has an important role in modulating hippocampal functions such as learning, memory and mood. Adult hippocampal neurogenesis is a multi-stage process, spanning from the activation and proliferation of hippocampal stem cells, to their differentiation into neurons. However, the stage-specific effects of noradrenergic receptors in regulating adult hippocampal neurogenesis remain poorly understood. In this study, we used transgenic Nestin-GFP mice and neurosphere assays to show that modulation of α2- and β-adrenergic receptor activity directly affects Nestin-GFP/GFAP-positive precursor cell population albeit in an opposing fashion. While selective stimulation of α2-adrenergic receptors decreases precursor cell activation, proliferation and immature neuron number, stimulation of β-adrenergic receptors activates the quiescent precursor pool and enhances their proliferation in the adult hippocampus. Furthermore, our data indicate no major role for α1-adrenergic receptors, as we did not observe any change in either the activation and proliferation of hippocampal precursors following selective stimulation or blockade of α1-adrenergic receptors. Taken together, our data suggest that under physiological as well as under conditions that lead to enhanced norepinephrine release, the balance between α2- and β-adrenergic receptor activity regulates precursor cell activity and hippocampal neurogenesis.
Dasyprocta cristata
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Dasyproctidae
Dasyprocta
Dasyprocta cristata

description: Dasyprocta cristata (Desmarest, 1816). Nouv. Diet. Hist. Nat., 2(1):215. TYPE LOCALITY: Surinam. DISTRIBUTION: Guianas. COMMENT: May be synonymous with leporina; see Husson, 1978:464-466, and Hershkovitz, 1972:311-341, in Keast et al., eds, Evolution, Mammals, and Southern Continents. ISIS NUMBER: 5301410022003006001.
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Rodentia (Part 6), pp. 560-594 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 576, DOI: 10.5281/zenodo.7353039
description: {"references": ["Husson, A. M. 1978. The mammals of Suriname. E. J. Brill, Leiden, 569 pp., 160 pls."]}
An Improved Estimator In Systematic Sampling
Creators: name: Singh, Rajesh
name: Malik, Sachin
name: Singh, Viplav K.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: In this paper we have adapted Bahl and Tuteja (1991) estimator in systematic sampling using auxiliary information. Using Bedi (1996) transformation an improved estimator is also proposed under systematic sampling. The expressions of bias and mean square error up to the first order of approximation are derived. It has been shown that the proposed estimator performs better than many existing estimators. A numerical example is included to support the theoretical results.
description: 6 pages, 1 table
Modeling Tissue- and Mutation- Specific Electrophysiological Effects in the Long QT Syndrome: Role of the Purkinje Fiber
Creators: name: Iyer, Vivek
name: Sampson, Kevin
name: Kass, Robert S.
Publisher: name: Columbia University
Year: 2014
Subjects: Long QT syndrome
Purkinje cells
Electrophysiology--Mathematical models
Medicine
Pharmacology

description: Congenital long QT syndrome is a heritable family of arrhythmias caused by mutations in 13 genes encoding ion channel complex proteins. Mounting evidence has implicated the Purkinje fiber network in the genesis of ventricular arrhythmias. In this study, we explore the hypothesis that long QT mutations can demonstrate different phenotypes depending on the tissue type of expression. Using computational models of the human ventricular myocyte and the Purkinje fiber cell, the biophysical alteration in channel function in LQT1, LQT2, LQT3, and LQT7 are modeled. We identified that the plateau potential was important in LQT1 and LQT2, in which mutation led to minimal action potential prolongation in Purkinje fiber cells. The phenotype of LQT3 mutation was dependent on the biophysical alteration induced as well as tissue type. The canonical ΔKPQ mutation causes severe action potential prolongation in both tissue types. For LQT3 mutation F1473C, characterized by shifted channel availability, a more severe phenotype was seen in Purkinje fiber cells with action potential prolongation and early afterdepolarizations. The LQT3 mutation S1904L demonstrated striking effects on action potential duration restitution and more severe action potential prolongation in Purkinje fiber cells at higher heart rates. Voltage clamp simulations highlight the mechanism of effect of these mutations in different tissue types, and impact of drug therapy is explored. We conclude that arrhythmia formation in long QT syndrome may depend not only on the basis of mutation and biophysical alteration, but also upon tissue of expression. The Purkinje fiber network may represent an important therapeutic target in the management of patients with heritable channelopathies.
title: Komische Erzählungen, ganz im mogol'schen Geschmack; 1796
title: mit Anmerkungen ; Aus dem Französischen
titleType: Subtitle
Creators: name: Marsollier des Vivetières, Benoît-Joseph
name: Marsollier des Vivetières, Benoît-Joseph
name: Marsollier des Vivetières, Benoît-Joseph
name: Marsollier des Vivetières, Benoît-Joseph
name: Marsollier des Vivetières, Benoît-Joseph
name: Marsollier des Vivetières, Benoît-Joseph
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2015

description: Enth.: Der Appetit kommt unterm Essen. Die neun Unglücksfälle Tursanoradins, Oberbarierer von Kalancala-Tze. Unglück ist doch zu etwas gut. Zirphis, oder die Einbildungskraft. - Verf. ermittelt. - In Fraktur
Dasyprocta fuliginosa Wagler 1832
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Dasyproctidae
Dasyprocta
Dasyprocta fuliginosa

description: Dasyprocta fuliginosa Wagler, 1832. Isis, 25: 1220. TYPE LOCALITY: Brazil, Amazonas, Borba, on lower Rio Madeira (-'Amazon River"). DISTRIBUTION: Colombia; S. Venezuela; Surinam; N. Brazil. Peru (TP). COMMENT: Reviewed by Allen, 1915, Bull. Am. Mus. Nat. Hist., 34:625. ISIS NUMBER: 5301410022003007001.
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Rodentia (Part 6), pp. 560-594 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 576, DOI: 10.5281/zenodo.7353039
Vampire Bats and Rabies: Toward an Ecological Solution to a Public Health Problem
Creators: name: Stoner-Duncan, Benjamin
name: Streicker, Daniel G.
name: Tedeschi, Christopher Michael
Publisher: name: Columbia University
Year: 2014
Subjects: subject: Rabies--Prevention
subject: Ecosystem management
subject: Vampire bats
subject: Ecology
subject: FOS: Biological sciences
subject: Public health

description: In the first half of 2011, 21 school-age children and two adults died of rabies transmitted by the common vampire bat (Desmodus rotundus) in and around the small rural village of Yupicusa in the Peruvian Amazon (Figure 1) [1]. This is only one of many such outbreaks occurring throughout the greater Amazon Basin (Figure 2), which, despite efforts at increasing education, vaccination, and bat population control, seem to have escalated over the last three decades—a timeline concurrent with major social and ecological changes in the area [2]. The remote and impoverished nature of communities affected by these outbreaks and the unique niche of vampire bats in a changing socioecological landscape create challenges beyond those faced in previous rabies control efforts and require new strategies to address this public health menace through ecosystem-level intervention. Here we examine this complex system and offer perspectives from a field expedition to Imaza following the 2011 outbreak.
Energy-Efficient Communication over the Unsynchronized Gaussian Diamond Network
Creators: name: Kolte, Ritesh
name: Niesen, Urs
name: Gupta, Piyush
Publisher: name: arXiv
Year: 2014
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: Communication networks are often designed and analyzed assuming tight synchronization among nodes. However, in applications that require communication in the energy-efficient regime of low signal-to-noise ratios, establishing tight synchronization among nodes in the network can result in a significant energy overhead. Motivated by a recent result showing that near-optimal energy efficiency can be achieved over the AWGN channel without requiring tight synchronization, we consider the question of whether the potential gains of cooperative communication can be achieved in the absence of synchronization. We focus on the symmetric Gaussian diamond network and establish that cooperative-communication gains are indeed feasible even with unsynchronized nodes. More precisely, we show that the capacity per unit energy of the unsynchronized symmetric Gaussian diamond network is within a constant factor of the capacity per unit energy of the corresponding synchronized network. To this end, we propose a distributed relaying scheme that does not require tight synchronization but nevertheless achieves most of the energy gains of coherent combining.
description: 20 pages, 4 figures, submitted to IEEE Transactions on Information Theory, presented at IEEE ISIT 2014
British Columbia Legislative Assembly sessional clipping book (1894-04)
Creators: name: :Unav
Publisher: name: University of Victoria Libraries
Year: 2022
Subjects: subject: Law
valueUri: http://id.worldcat.org/fast/993678
subject: FOS: Law
subject: British Columbia. Legislative Assembly
valueUri: http://id.worldcat.org/fast/600765
subject: Politics and government
valueUri: http://id.worldcat.org/fast/1919741

description: These Sessional Clippings books cover the period 1891 to 1972, and include newspaper accounts written by various legislative reporters who covered debates occurring in the British Columbia Legislative Assembly. Transcripts of debates of the Legislative Assembly (Hansard) were not published in B.C. until 1970; hence these "Sessional Clipping Books" augment the "Journals", the record of daily proceedings of the Legislative Assembly. Selected clippings from various newspapers including the Vancouver Sun, the Vancouver Province, the Colonist, and the Times newspapers, relating to the newspaper reports concerning activities of the Legislature. The original sessional clippings books comprise 351 ledger size print volumes, held at the Legislative Library in Victoria BC. The print volumes were microfilmed onto 26 reels in 1977 under a Tri University Libraries (TRIUL) project by Precision Micrographic Services (Vancouver, B.C.), with the permission of the Legislative Library, Victoria, British Columbia. This digital collection was created by scanning the 26 microfilm reels.
Spatial Transmission of 2009 Pandemic Influenza in the US
Creators: name: Gog, Julia R.
name: Ballesteros, Sébastien
name: Viboud, Cécile
name: Simonsen, Lone
name: Bjornstad, Ottar N.
name: Shaman, Jeffrey L.
name: Chao, Dennis L.
name: Khan, Farid
name: Grenfell, Bryan T.
Publisher: name: Columbia University
Year: 2014
Subjects: Virus diseases--Transmission
Virus diseases in children
H1N1 influenza
Epidemiology
Environmental health

description: The 2009 H1N1 influenza pandemic provides a unique opportunity for detailed examination of the spatial dynamics of an emerging pathogen. In the US, the pandemic was characterized by substantial geographical heterogeneity: the 2009 spring wave was limited mainly to northeastern cities while the larger fall wave affected the whole country. Here we use finely resolved spatial and temporal influenza disease data based on electronic medical claims to explore the spread of the fall pandemic wave across 271 US cities and associated suburban areas. We document a clear spatial pattern in the timing of onset of the fall wave, starting in southeastern cities and spreading outwards over a period of three months. We use mechanistic models to tease apart the external factors associated with the timing of the fall wave arrival: differential seeding events linked to demographic factors, school opening dates, absolute humidity, prior immunity from the spring wave, spatial diffusion, and their interactions. Although the onset of the fall wave was correlated with school openings as previously reported, models including spatial spread alone resulted in better fit. The best model had a combination of the two. Absolute humidity or prior exposure during the spring wave did not improve the fit and population size only played a weak role. In conclusion, the protracted spread of pandemic influenza in fall 2009 in the US was dominated by short-distance spatial spread partially catalysed by school openings rather than long-distance transmission events. This is in contrast to the rapid hierarchical transmission patterns previously described for seasonal influenza. The findings underline the critical role that school-age children play in facilitating the geographic spread of pandemic influenza and highlight the need for further information on the movement and mixing patterns of this age group.
Dasyprocta guamara Ojasti 1972
Creators: name: Honacki, James H.
name: Kinman, Kenneth E.
name: Koeppl, James W.
Publisher: name: Zenodo
Year: 1982
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Dasyproctidae
Dasyprocta
Dasyprocta guamara

description: Dasyprocta guamara Ojasti, 1972. Mem. Soc. Cienc. Nat. La Salle, 32: 176. TYPE LOCALITY: Venezuela, Delta Amacuro, Araguabisi, 9° 13' 27" N., 61° 0' 16" W. DISTRIBUTION: Orinoco Delta (Venezuela).
description: Published as part of James H. Honacki, Kenneth E. Kinman & James W. Koeppl, 1982, Order Rodentia (Part 6), pp. 560-594 in Mammal Species of the World (1 st Edition), Lawrence, Kansas, USA :Alien Press, Inc. & The Association of Systematics Collections on page 576, DOI: 10.5281/zenodo.7353039
Neutron-proton pairs in nuclei
Creators: name: Van Isacker, P.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: A review is given of attempts to describe nuclear properties in terms of neutron--proton pairs that are subsequently replaced by bosons. Some of the standard approaches with low-spin pairs are recalled but the emphasis is on a recently proposed framework with pairs of neutrons and protons with aligned angular momentum. The analysis is carried out for general $j$ and applied to $N=Z$ nuclei in the $1f_{7/2}$ and $1g_{9/2}$ shells.
description: 16 figures, 4 tables, accepted for publication in Int. J. of Modern Physics E
The synthesis and application of a colour-switch β-arylethenesulfonyl fluoride fluorescent probe in the detection of serum albumin
Creators: name: Giel, Marie-Claire
name: Owyong, Tze Cin
name: Hong, Yuning
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 34
subject: Chemical sciences
subject: FOS: Chemical sciences

description: Proteins play a pivotal role in regulating important physiological processes and serve as important biomarkers for many diseases. Herein, we present a new strategy for bovine serum albumin (BSA) detection using a novel colour-switch fluorescent probe CPV-ESF ((E)-2-(4-((Z)-1-cyano-2-(4-(diethylamino)phenyl)vinyl)phenyl)ethene-1-sulfonyl fluoride). CPV-ESF reacts with nucleophilic amino acids of BSA via 1,4-Michael addition click chemistry to create a covalently linked CPV-ESF:BSA complex, which can be easily detected by a fluorescence colour-switch response. The sensing mechanism, sensitivity and selectivity of CPV-ESF for BSA detection as well as its application for cell imaging have been investigated.
British Columbia Legislative Assembly sessional clipping book (1897-05)
Creators: name: :Unav
Publisher: name: University of Victoria Libraries
Year: 2022
Subjects: subject: British Columbia. Legislative Assembly
valueUri: http://id.worldcat.org/fast/600765
subject: Politics and government
valueUri: http://id.worldcat.org/fast/1919741
subject: Law
valueUri: http://id.worldcat.org/fast/993678
subject: FOS: Law

description: These Sessional Clippings books cover the period 1891 to 1972, and include newspaper accounts written by various legislative reporters who covered debates occurring in the British Columbia Legislative Assembly. Transcripts of debates of the Legislative Assembly (Hansard) were not published in B.C. until 1970; hence these "Sessional Clipping Books" augment the "Journals", the record of daily proceedings of the Legislative Assembly. Selected clippings from various newspapers including the Vancouver Sun, the Vancouver Province, the Colonist, and the Times newspapers, relating to the newspaper reports concerning activities of the Legislature. The original sessional clippings books comprise 351 ledger size print volumes, held at the Legislative Library in Victoria BC. The print volumes were microfilmed onto 26 reels in 1977 under a Tri University Libraries (TRIUL) project by Precision Micrographic Services (Vancouver, B.C.), with the permission of the Legislative Library, Victoria, British Columbia. This digital collection was created by scanning the 26 microfilm reels.
The beaming pattern of External Compton Emission from relativistic outflows
Creators: name: Kelner, S. R.
name: Lefa, E.
name: Rieger, F. M.
name: Aharonian, F. A.
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The beaming pattern of radiation emitted by a relativistically moving source like jets in microquasars, AGN and GRBs, is a key issue for understanding of acceleration and radiation processes in these objects. In this paper we introduce a formalism based on a solution of the photon transfer equation to study the beaming patterns for emission produced by electrons accelerated in the jet and upscattering photons of low-energy radiation fields of external origin (the so-called External Compton scenario). The formalism allows us to treat non-stationary, non-homogeneous and anisotropic distributions of electrons, but assuming homogeneous/isotropic and non-variable target photon fields. We demonstrate the non-negligible impact of the anisotropy in the electron distribution on angular and spectral characteristics of the EC radiation.
description: 7 pages, 2 figures