cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Amtliche Mitteilungen der Technischen Universität Dortmund Nr. 20/2014
Creators: name: (:Unkn) Unknown
Publisher: name: Technische Universität Dortmund
Year: 2014
Subjects: subject: 080

description: Hausordnung der Technischen Universität Dortmund
description: Dienstvereinbarung Führungskräfte-Feedback (FKF)
description: Verwaltungs- und Benutzungsordnung des Instituts für Konstruktion und Werkstoffprüfung (IKW) der Fakultät Maschinenbau der Technischen Universität Dortmund vom 16. Dezember 2014
description: Amtliche Mitteilungen der Technischen Universität Dortmund ; 20, 2014
Ruh, Ulrich (Hg.): Das Jesusbuch des Papstes - Die Debatte
Creators: name: Kreiml, Josef
Publisher: name: Forum Katholische Theologie
Year: 1970

description: Forum Katholische Theologie, Bd. 24 Nr. 2 (2008): Forum Katholische Theologie, Band 24, Heft 2
Public Servants" Attitude towards Professional Ethics and Its Implication for Service Delivery in Selected Bureaus of the Oromia Regional State
Creators: name: Gelaye, Midaksa
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2018

description: The purpose of this study was to assess the public servants" attitude towards professional ethics and its implication for service delivery at Oromia Regional State in the selected Bureaus. Moreover, detail investigations were made on the codes of conduct adopted, the common ethical problems prevailing and the major causes of unethical behavioral problems prevailing in the selected bureaus. Samples of 178 public servants were selected for the study using systematic and simple random sampling technique. Key informant interview was done on purposely selected officers from 3 bureaus and from each 5 and totally 15 officers participated in the key informant interview. The collected data was analyzed using simple statistical techniques, simple descriptive techniques and description narratives in presenting qualitative data. The finding of the study showed that the selected bureaus don"t have their own codes of conduct but they have common codes of conduct and its enforcement or implementation was relatively low. This low enforcement is resulted because the codes of conduct were not introduced to employees, management bodies and hence the civil servants don"t follow its procedures while performing their duties. The finding on the attitude of public servants indicated that the public servants viewed those unethical behavioral problems like violating rules and regulations considered as positive practices. Furthermore, misuse of power, non-observance of rules and working procedures, personal use of work-related resources, falsifying work (time and expense) reports, fraud in performing duties, wasting, mismanaging or abusing organizational asset and resources were found to be the common ethical problems identified in this study. The study also indicated that lack of capacity and training, lack of trust between employees and the management, low salary of employees, permissive leadership, and inadequate political interference as major reasons that caused the prevailing ethical problems among the study population. Finally, the study indicated that the public servants professional ethics based service deliveryis effective in some ethical principles and less in the enforcements of honestly, respecting the law and accountability. This implies that the service delivery system is not based on serving the public interest. Hence, it was recommended that the public servants in Oromia regional state should give more attention to serve the public interests while enforcing professional ethics principles during carrying out their duties at different public institutions.
Impact of dimerization and N3 binding on molecular dynamics of SARS-CoV and SARS-CoV-2 main proteases
Creators: name: Tekpinar, Mustafa
name: Yildirim, Ahmet
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Computational Biology

description: SARS-CoV-2 main protease is one of the major targets in drug development efforts against Covid-19. Even though several structures were reported to date, its dynamics is not understood well. In particular, impact of dimerization and ligand binding on the dynamics is an important issue to investigate. In this study, we performed molecular dynamics simulations of SARS-CoV and SARS-CoV-2 main proteases to investigate influence of dimerization on the dynamics by modeling monomeric and dimeric apo and holo forms. The dimerization causes an organization of the interdomain dynamics as well as some local structural changes. Moreover, we investigated impact of a peptide mimetic (N3) on the dynamics of SARS-CoV and SARS-CoV-2 Mpro. The ligand binding to the dimeric forms causes some key local changes at the dimer interface and it causes an allosteric interaction between the active sites of two protomers. Our results support the idea that only one protomer is active on SARS-CoV-2 due to this allosteric interaction. Additionally, we analyzed the molecular dynamics trajectories from graph theoretical perspective and found that the most influential residues – as measured by eigenvector centrality – are a group of residues in active site and dimeric interface of the protease. This study may form a bridge between what we know about the dynamics of SARS-CoV and SARS-CoV-2 Mpro. We think that enlightening allosteric communication of the active sites and the role of dimerization in SARS-CoV-2 Mpro can contribute to development of novel drugs against this global health problem as well as other similar proteases. Communicated by Ramaswamy H. Sarma
Chiral interface states in graphene $p$-$n$ junctions
Creators: name: Cohnitz, L.
name: De Martino, A.
name: Häusler, W.
name: Egger, R.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We present a theoretical analysis of unidirectional interface states which form near $p$-$n$ junctions in a graphene monolayer subject to a homogeneous magnetic field. The semiclassical limit of these states corresponds to trajectories propagating along the $p$-$n$ interface by a combined skipping-snaking motion. Studying the two-dimensional Dirac equation with a magnetic field and an electrostatic potential step, we provide and discuss the exact and essentially analytical solution of the quantum-mechanical eigenproblem for both a straight and a circularly shaped junction. The spectrum consists of localized Landau-like and unidirectional snaking-skipping interface states, where we always find at least one chiral interface state. For a straight junction and at energies near the Dirac point, when increasing the potential step height, the group velocity of this state interpolates in an oscillatory manner between the classical drift velocity in a crossed electromagnetic field and the semiclassical value expected for a purely snaking motion. Away from the Dirac point, chiral interface states instead resemble the conventional skipping (edge-type) motion found also in the corresponding Schrödinger case. We also investigate the circular geometry, where chiral interface states are predicted to induce sizeable equilibrium ring currents.
description: 12 pages, 12 figures, final version accepted for publication in PRB
Cytochrome P450 enzyme mediated herbal drug interactions (Part 2)
Creators: name: Wanwimolruk, Sompon
name: Phopin, Kamonrat
name: Prachayasittikul, Virapong
Publisher: name: Technische Universität Dortmund
Year: 2014
Subjects: subject: Herbal drug interactions
subject: CYP
subject: dietary supplements
subject: herbal medicines
subject: Chinese herbal medicines
subject: drug interactions
subject: 610

description: To date, a number of significant herbal drug interactions have their origins in the alteration of cytochrome P450 (CYP) activity by various phytochemicals. Among the most noteworthy are those involving St. John's wort and drugs metabolized by human CYP3A4 enzyme. This review article is the continued work from our previous article (Part 1) published in this journal (Wanwimolruk and Prachayasittikul, 2014). This article extends the scope of the review to six more herbs and updates information on herbal drug interactions. These include black cohosh, ginseng, grape seed extract, green tea, kava, saw palmetto and some important Chinese medicines are also presented. Even though there have been many studies to determine the effects of herbs and herbal medicines on the activity of CYP, most of them were in vitro and in animal studies. Therefore, the studies are limited in predicting the clinical relevance of herbal drug interactions. It appeared that the majority of the herbal medicines have no clear effects on most of the CYPs examined. For example, the existing clinical trial data imply that black cohosh, ginseng and saw palmetto are unlikely to affect the pharmacokinetics of conventional drugs metabolized by human CYPs. For grape seed extract and green tea, adverse herbal drug interactions are unlikely when they are concomitantly taken with prescription drugs that are CYP substrates. Although there were few clinical studies on potential CYP-mediated interactions produced by kava, present data suggest that kava supplements have the ability to inhibit CYP1A2 and CYP2E1 significantly. Therefore, caution should be taken when patients take kava with CYP1A2 or CYP2E1 substrate drugs as it may enhance their therapeutic and adverse effects. Despite the long use of traditional Chinese herbal medicines, little is known about the potential drug interactions with these herbs. Many popularly used Chinese medicines have been shown in vitro to significantly change the activity of human CYP. However, with little confirming evidence from clinical studies, precaution should be exercised when patients are taking Chinese herbal medicines concomitantly with drugs that are CYP substrates. Currently there is sufficient evidence to indicate that herbal drug interactions can occur and may lead to serious clinical consequence. Further clinical trial research should be conducted to verify these herbal drug interactions. Education on herbal drug interactions and communication with patients on their use of herbal products is also important.
description: EXCLI Journal ; Vol. 13, 2014
Israeli memory of the confrontation between Jews and Palestinians over the land of Israel-Palestine
Creators: name: Tsalamandris, Theo.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Effect of variations in the conserved residues E371 and S359 on the structural dynamics of protein Z dependent protease inhibitor (ZPI): a molecular dynamic simulation study
Creators: name: Gayathri, Subash Chellam
name: Gupta, Suchetana
name: Suresh, Aravind
name: Senapati, Sanjib
name: Sengupta, Tanusree
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: 60506 Virology
subject: FOS: Biological sciences
subject: Computational Biology

description: Protein Z (PZ) dependent protease inhibitor (ZPI) is a natural anticoagulant inhibiting blood coagulation proteases fXa and fXIa. Despite being a member of the serpin superfamily, it possesses unique structural features such as activation by PZ, regulating its inhibitory function. In order to understand the Reactive Centre Loop (RCL) dynamics of ZPI, which is absolutely critical for its activity, we performed Molecular Dynamics (MD) simulation on ZPI and its E371 and S359 variants located at important conserved functional sites. Unexpectedly, the RCL of E371 variants, (E371K, E371R, and E371Q), were shown to be very stable due to compensatory interactions at the proximal end of RCL. Interestingly, RCL flexibility was shown to be enhanced in the double mutant K318E-E371K due to the repulsive effect of increased negative charge on top of the breach region. Principal component analysis (PCA) coupled with residue wise interaction network analysis(RIN) revealed correlated motion between the RCL and the PZ binding regions in the WT. However, a loss of regulation in correlated motion between RCL and PZ binding hotspot Tyr240 in the double mutant was also observed. Additionally, the S359F and S359I mutations resulted in increased RCL flexibility owing to the disruption of stabilizing hydrogen bonding interaction at the distal end of strand S5A. Thus, the current study proposes that the overall stabilizing interactions of S5A is a major regulator of proper loop movement of ZPI for its activity. The results would be beneficial to engineer activity compromised ZPI as a prophylactic agent for the treatment of hemophilia. Communicated by Ramaswamy H. Sarma
Unconventional topological phase transition in two-dimensional systems with space-time inversion symmetry
Creators: name: Ahn, Junyeong
name: Yang, Bohm-Jung
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We study a topological phase transition between a normal insulator and a quantum spin Hall insulator in two-dimensional (2D) systems with time-reversal and two-fold rotation symmetries. Contrary to the case of ordinary time-reversal invariant systems where a direct transition between two insulators is generally predicted, we find that the topological phase transition in systems with an additional two-fold rotation symmetry is mediated by an emergent stable two-dimensional Weyl semimetal phase between two insulators. Here the central role is played by the so-called space-time inversion symmetry, the combination of time-reversal and two-fold rotation symmetries, which guarantees the quantization of the Berry phase around a 2D Weyl point even in the presence of strong spin-orbit coupling. Pair-creation/pair-annihilation of Weyl points accompanying partner exchange between different pairs induces a jump of a 2D $Z_{2}$ topological invariant leading to a topological phase transition. According to our theory, the topological phase transition in HgTe/CdTe quantum well structure is mediated by a stable 2D Weyl semimetal phase since the quantum well, lacking inversion symmetry intrinsically, has two-fold rotation about the growth direction. Namely, the HgTe/CdTe quantum well can show 2D Weyl semimetallic behavior within a small but finite interval in the thickness of HgTe layers between a normal insulator and a quantum spin Hall insulator. We also propose that few-layer black phosphorus under perpendicular electric field is another candidate system to observe the unconventional topological phase transition mechanism accompanied by emerging 2D Weyl semimetal phase protected by space-time inversion symmetry.
description: 5+14 pages, 4+10 figures; accepted for publication in Physical Review Letters
Improving the Correlation Lower Bound for Simultaneous Orthogonal Matching Pursuit
Creators: name: Determe, Jean-François
name: Louveaux, Jérôme
name: Jacques, Laurent
name: Horlin, François
Publisher: name: arXiv
Year: 2016
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: The simultaneous orthogonal matching pursuit (SOMP) algorithm aims to find the joint support of a set of sparse signals acquired under a multiple measurement vector model. Critically, the analysis of SOMP depends on the maximal inner product of any atom of a suitable dictionary and the current signal residual, which is formed by the subtraction of previously selected atoms. This inner product, or correlation, is a key metric to determine the best atom to pick at each iteration. This paper provides, for each iteration of SOMP, a novel lower bound of the aforementioned metric for the atoms belonging to the correct and common joint support of the multiple signals. Although the bound is obtained for the noiseless case, its main purpose is to intervene in noisy analyses of SOMP. Finally, it is shown for specific signal patterns that the proposed bound outperforms state-of-the-art results for SOMP, and orthogonal matching pursuit (OMP) as a special case.
The Study of Technoscientific Imaging in STS
Creators: name: Perrotta, Manuela
Publisher: name: Tecnoscienza – Italian Journal of Science & Technology Studies
Year: 2013

description: In the last few years a flourishing debate has developed on visualization processes and practices of representation in technoscience, fostering an interdisciplinary approach to the study of the production and dissemination of images. This Scenario outlines some of the current examples of research in this area, introducing the turn from the study of scientific representation to that of (techno)scientific imaging and visualization. Three main areas of research are discussed: technoscientific imaging in practice; images as evidence; images, imaginations and imaginaries. Finally, some further questions and challanges concerning the future study of technoscientific imaging are raised.
description: Tecnoscienza – Italian Journal of Science & Technology Studies, Vol. 3 No. 2 (2012): Tecnoscienza Nr. 6
The serpent in the poetry and sermons of John Donne
Creators: name: Beal, Mary E.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
HeLa. Reconstructing an Immortal Bio
Creators: name: Casati, Sara
name: Crabu, Stefano
name: Lavitrano, Marialuisa
name: Turrini, Mauro
Publisher: name: Tecnoscienza – Italian Journal of Science & Technology Studies
Year: 2013

description: Henrietta Lacks died of cervical cancer in 1951 at 31, but a cell line from her tissues is still alive and reproducing for scientific purposes. Her dramatic biography and her fundamental (although unwitting) contribution to the development of scientific knowledge went unnoticed until Rebecca Skloot's "The immortal life of Henrietta Lacks" [New York, Random House, 2010, 384 pp.] was published. The political, scientific, social and technological entanglement of Henrietta's account by Skloot is an original and vivid science narrative of clear relevance for Science and Technology Studies. Stemming from Henrietta's story and Skloot's book, Stefano Crabu, Mauro Turrini, Marialuisa Lavitrano and Sara Casati reflect and discuss on the relation between society and medical research, its ethical dilemmas, as well as on the way technoscientific processes can be accounted for.
description: Tecnoscienza – Italian Journal of Science & Technology Studies, Vol. 3 No. 2 (2012): Tecnoscienza Nr. 6
Ticket for Troop ship "Cameronia" [Wills Photograph Album Page 87]
Creators: name: :Unav
Publisher: name: University of Victoria Libraries
Year: 2022
Subjects: subject: Transports
valueUri: http://id.worldcat.org/fast/1155410
subject: Transportation, Military
valueUri: http://id.worldcat.org/fast/1155397
subject: World War (1914-1918)
valueUri: http://id.worldcat.org/fast/1180746
subject: Ships
valueUri: http://id.worldcat.org/fast/1116439

description: A ticket for Troop ship "Cameronia." Section (upper) 2 'tween deck.
In silico design of enzyme α-amylase and α-glucosidase inhibitors using molecular docking, molecular dynamic, conceptual DFT investigation and pharmacophore modelling
Creators: name: Chenafa, Hadjer
name: Mesli, Fouzia
name: Daoud, Ismail
name: Achiri, Radja
name: Ghalem, Said
name: Neghra, Abdelhak
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: Type 2 diabetes mellitus (T2DM) is characterized by elevated blood glucose levels and can lead to serious complications such as nephropathy, neuropathy, retinopathy and cardiovascular disease. The aim of this work is to identify and investigate the inhibition mechanism of natural flavonoids and phenolics acids against, the α-amylase (αA) and α-glucosidase (αG). Therefore, we used different approaches; such as conceptual DFT and pharmacophore mapping in addition to molecular mechanics, dynamics and docking simulations. Whereas, a close agreement was found out to decide that Linarin (Flavones) provides more optimized inhibition of αA and αG enzymes. Our results have shown that Linarin could be useful as preventative agent, and possibly therapeutic modality for the treatment of metabolic diseases. Communicated by Ramaswamy H. Sarma
"The passion of the outside" : inside Maurice Blanchot's Thomas the obscure
Creators: name: Pericic, Patricia.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Polyakov loop and heavy quark entropy in strong magnetic fields from holographic black hole engineering
Creators: name: Critelli, Renato
name: Rougemont, Romulo
name: Finazzo, Stefano I.
name: Noronha, Jorge
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Theory (hep-th)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We investigate the temperature and magnetic field dependence of the Polyakov loop and heavy quark entropy in a bottom-up Einstein-Maxwell-dilaton (EMD) holographic model for the strongly coupled quark-gluon plasma (QGP) that quantitatively matches lattice data for the $(2+1)$-flavor QCD equation of state at finite magnetic field and physical quark masses. We compare the holographic EMD model results for the Polyakov loop at zero and nonzero magnetic fields and the heavy quark entropy at vanishing magnetic field with the latest lattice data available for these observables and find good agreement for temperatures $T\gtrsim 150$ MeV and magnetic fields $eB\lesssim 1$ GeV$^2$. Predictions for the behavior of the heavy quark entropy at nonzero magnetic fields are made that could be readily tested on the lattice.
description: 7 pages, 2 figures, version accepted for publication in Physical Review D
Formatting Culture. The Mpeg group and the technoscientific innovation by digital formats
Creators: name: Chiariglione, Leonardo
name: Magaudda, Paolo
Publisher: name: Tecnoscienza – Italian Journal of Science & Technology Studies
Year: 2013

description: This conversation reconstructs the process of technoscientific innovation of digital formats pursued in the ‘80s by the MPEG group led by Leonardo Chiariglione. Through a historical and cultural frame provided by Paolo Magaudda and the very words of the main character of this technoscientific story, Leonardo Chiariglione, the contribution gives fresh insights into the relationship between sociotechnical standards and the digitization of media culture.
description: Tecnoscienza – Italian Journal of Science & Technology Studies, Vol. 3 No. 2 (2012): Tecnoscienza Nr. 6
Financial Markets, Climate Change and STS
Creators: name: Pellegrino, Giuseppina
name: Perna, Tonino
name: Salemmi, Iacopo
Publisher: name: Tecnoscienza – Italian Journal of Science & Technology Studies
Year: 2013

description: Departing from a fascinating analogy between financial and climate fluctuations proposed by Tonino Perna under the category of “extreme events”, this conversation addresses crucial issues in contemporary society, such as the relationship between financial capitalism and real economies, the controversies around alternative development models, and the role of the media in fabricating emergencies and crises. Whereas Perna interrogates macro-economic historical trends, Pellegrino and Salemmi put forward an STS approach into the topic, in order to frame the role of information infrastructures, controversies and the media (Pellegrino) and questioning the primacy of Economics as objective science through the hypothesis of economical medicalization of our society (Salemmi).
description: Tecnoscienza – Italian Journal of Science & Technology Studies, Vol. 3 No. 2 (2012): Tecnoscienza Nr. 6
Supergravity Backgrounds for Four-Dimensional Maximally Supersymmetric Yang-Mills
Creators: name: Maxfield, Travis
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this note, we describe supersymmetric backgrounds for the four-dimensional maximally supersymmetric Yang-Mills theory. As an extension of the method of Festuccia and Seiberg to sixteen supercharges in four dimensions, we utilize the coupling of the gauge theory to maximally extended conformal supergravity. Included among the fields of the conformal supergravity multiplet is the complexified coupling parameter of the gauge theory; therefore, backgrounds with spacetime varying coupling--such as appear in F-theory and Janus configurations--are naturally included in this formalism. We demonstrate this with a few examples from past literature.
description: 22 pages, LaTeX; v2: typos corrected; v3: reference added, published version
Colonial mimicry, myth or reality : a discourse analysis on postcolonial ethnic writers and ethnic writings in English
Creators: name: Koh, Alvin Lye Huat.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Konzepte der Lehrerbildung
Creators: name: Reiss, Kristina
name: Prenzel, Manfred
name: Rinkens, Hans-Dieter
name: Kramer, Jürg
Publisher: name: Gesellschaft für Didaktik der Mathematik
Year: 2010
Subjects: subject: 510

description: Beutelspacher, Albrecht ; Danckwerts, Rainer: Mathematik Neu Denken
description: Hefendehl-Hebeker, Lisa ; Ableitinger, Christoph ; Herrmann, Angela: Mathematik Besser Verstehen
description: Reiss, Kristina ; Prenzel, Manfred: Impulse für die Lehramtsausbildung: TUM School of Education
description: Prediger, Susanne: Fachinhaltliches Wissen und Können für fachdidaktisches Handeln verfügbar machen - Ergänzungsvorschläge für eine professionsorientierte fachinhaltliche Mathematik-Lehrerbildung
description: Kramer, Jürg ; Warmuth, Elke: Mathematik-Lehrerbildung: HU-Modell
Le calcul du coefficient de diffusion apparent en imagerie par résonance magnétique : un outil prometteur pour prédire le grade histologique du carcinome hépatocellulaire.
Creators: name: Benmamar, Hichem El Azhari
name: Sebti1, Draouat
Publisher: name: figshare
Year: 2022
Subjects: Radiology and organ imaging

description: The prognosis of hepatocellular carcinoma remains unsatisfactory due to a high incidence of postoperative recurrence which exceeds 60% at 5 years and the poor histological differentiation of this tumor is the main predictive factor for recurrence after surgical resection. The main objective of this study is to evaluate the usefulness of calculation of the apparent diffusion coefficient (ADC) in diffusion imaging (DWI) for the prediction of the histological grade of hepatocellular carcinoma.
Evaluation of binding of potential ADMET/tox screened saquinavir analogues for inhibition of HIV-protease via molecular dynamics and binding free energy calculations
Creators: name: Jayaswal, Amit
name: Pathak, Ekta
name: Mishra, Hirdyesh
name: Shah, Kavita
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Computational Biology

description: Developing novel drug molecules against HIV is a scientific quest necessitated by development of drug resistance against used drugs. We report comparative results of molecular dynamics simulation studies on 11 structural analogues of Saquinavir (SQV) – against HIV-protease that were earlier examined for pharmacodynamic and pharmacokinetic properties. We reported analogues S1, S5 and S8 to qualify the ADMET criterion and may be considered as potential lead molecules. In this study the designed molecules were successively docked with native HIV-protease at AutoDock. Docking scores established relative goodness of the 11 analogues against the benchmark for Saquinavir. The docked complexes were subjected to molecular dynamics simulation studies using GROMACS 4.6.2. Four parameters viz. H-bonding, RMSD, Binding energy and Protein–Ligand Distance were used for comparative analyses of the analogues relative to Saquinavir. The comparison and analysis of the results are indicative that analogues S8, S9 and S1 are promising candidates among all the analogues studied. From our earlier work and present study it is evident that among the three S8 and S1 qualify the ADMET criterion and between S1 and S8, the analogue S8 shows more target efficacy and specificity over S1 and have better molecular dynamics simulation results. Thus, of the 11 de novo Saquinavir analogues, the S8 appears to be the most promising candidate as lead molecule for HIV-protease inhibitor and is best suited for testing under biological system. Further validation of the proposed lead molecules through wet lab studies involving antiviral assays however is required. Communicated by Ramaswamy H. Sarma
Behind Closed Doors. Scientists’ and Science Communicators’ Discourses on Science in Society. A Study Across European Research Institutions
Creators: name: Casini, Silvia
name: Neresini, Federico
Publisher: name: Tecnoscienza – Italian Journal of Science & Technology Studies
Year: 2013

description: Public Engagement (PE) is a marginalized field within a science institute’s "core business" of doing research. Using interview data from a range of science professionals working in European research institutions, this study addresses fundamental questions about science communication: What role do scientists think they should have in SiS activities? What audience do scientists think they should address? Despite an openess to experiment with PE initiatives, the deficit model remains dominant among research practitioners. The importance of the institutional factor emerges, namely research institutions failure to recognize SiS activities as an integral part of the research profession.
description: Tecnoscienza – Italian Journal of Science & Technology Studies, Vol. 3 No. 2 (2012): Tecnoscienza Nr. 6
Monoid-like definitions of cyclic operads
Creators: name: Obradović, Jovana
Publisher: name: arXiv
Year: 2016
Subjects: subject: Category Theory (math.CT)
subject: FOS: Mathematics
subject: 18D50, 18D10, 05A99

description: Guided by the microcosm principle of Baez-Dolan and by the algebraic definitions of operads of Kelly and Fiore, we introduce two "monoid-like" definitions of cyclic operads, one for the original, "exchangable-output" characterisation of Getzler-Kapranov, and the other for the alternative "entries-only" characterisation, both within the category of Joyal's species of structures. Relying on a result of Lamarche on descent for species, we use these "monoid-like" definitions to prove the equivalence between the "exchangable-output" and "entries-only" points of view on cyclic operads.
"Has anyone heard the one about ...?" : a sociological study of urban legends in conversation
Creators: name: Fong, Maria.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
The Gribov problem in presence of background field for $SU(2)$ Yang-Mills theory
Creators: name: Canfora, Fabrizio
name: Hidalgo, Diego
name: Pais, Pablo
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The Gribov problem in the presence of a background field is analyzed: in particular, we study the Gribov copies equation in the Landau-De Witt gauge as well as the semi-classical Gribov gap equation. As background field, we choose the simplest non-trivial one which corresponds to a constant gauge potential with non-vanishing component along the Euclidean time direction. This kind of constant non-Abelian background fields is very relevant in relation with (the computation of) the Polyakov loop but it also appears when one considers the non-Abelian Schwinger effect. We show that the Gribov copies equation is affected directly by the presence of the background field, constructing an explicit example. The analysis of the Gribov gap equation shows that the larger the background field, the smaller the Gribov mass parameter. These results strongly suggest that the relevance of the Gribov copies (from the path integral point of view) decreases as the size of the background field increases.
description: 14 pages; 2 figures. In the new version a small but non-zero temperature has been included. Typo corrected. The numerical results basically unchanged
Pandora’s Box: Opening Up Finance to STS Investigations
Creators: name: Preda, Alex
Publisher: name: Tecnoscienza – Italian Journal of Science & Technology Studies
Year: 2013

description: Only two decades ago, finance was mainly the province of economics, a territory into which only few outsiders wandered. Nowadays, finance has be- come a central topic and various social science and humanities disciplines, have made inroads into this territory. Should the social sciences (and STS in particular) just analyse finance, or should they mainly criticize it, or maybe even provide what some have called an alternative narrative to capitalist finance? Stemming from an ironic and innovative overview of social studies of finance (SSF), the paper presents the core characteristics of such a perspective, taking in- to account also the main critique that SSF attracted. The contribution concentrates then on the three issues where STS investigations of finance promise good yields: (1) agency and robots; (2) epistemic cultures; (3) expertise.
description: Tecnoscienza – Italian Journal of Science & Technology Studies, Vol. 3 No. 2 (2012): Tecnoscienza Nr. 6
Katholisches Säkularinstitut Cruzadas de Santa Maria (Hg.): Kriterien der Wahrheit christlicher Glaubenserfahrung
Creators: name: Ziegenaus, Anton
Publisher: name: Forum Katholische Theologie
Year: 1970

description: Forum Katholische Theologie, Bd. 24 Nr. 1 (2008): Forum Katholische Theologie, Band 24, Heft 1
Star-galaxy Classification Using Deep Convolutional Neural Networks
Creators: name: Kim, Edward J.
name: Brunner, Robert J.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Most existing star-galaxy classifiers use the reduced summary information from catalogs, requiring careful feature extraction and selection. The latest advances in machine learning that use deep convolutional neural networks allow a machine to automatically learn the features directly from data, minimizing the need for input from human experts. We present a star-galaxy classification framework that uses deep convolutional neural networks (ConvNets) directly on the reduced, calibrated pixel values. Using data from the Sloan Digital Sky Survey (SDSS) and the Canada-France-Hawaii Telescope Lensing Survey (CFHTLenS), we demonstrate that ConvNets are able to produce accurate and well-calibrated probabilistic classifications that are competitive with conventional machine learning techniques. Future advances in deep learning may bring more success with current and forthcoming photometric surveys, such as the Dark Energy Survey (DES) and the Large Synoptic Survey Telescope (LSST), because deep neural networks require very little, manual feature engineering.
description: 13 page, 13 figures. Accepted for publication in the MNRAS. Code available at https://github.com/EdwardJKim/dl4astro
The dilemma of the mid-sized superpower ally : Australia-Taiwan relations
Creators: name: Eastwood, Edward.
Publisher: name: Monash University
Year: 2022

description: This thesis was scanned from the print manuscript for digital preservation and is copyright the author.
 Researchers can access this thesis by asking their local university, institution or public library to
 make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Deep inelastic scattering on ultracold gases
Creators: name: Hofmann, Johannes
name: Zwerger, Wilhelm
Publisher: name: arXiv
Year: 2016
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We discuss Bragg scattering on both Bose and Fermi gases with strong short-range interactions in the deep inelastic regime of large wave vector transfer $q$, where the dynamic structure factor is dominated by a resonance near the free-particle energy $\hbarω=\varepsilon_{\bf q}=\hbar^2q^2/2m$. Using a systematic short-distance expansion, the structure factor at high momentum is shown to exhibit a nontrivial dependence on frequency characterized by two separate scaling regimes. First, for frequencies that differ from the single-particle energy by terms of order ${\cal O}(q)$ (i.e., small deviations compared to the single-particle energy), the dynamic structure factor is described by the impulse approximation of Hohenberg and Platzman. Second, deviations of order ${\cal O}(q^2)$ (i.e., of the same order or larger than the single-particle energy) are described by the operator product expansion, with a universal crossover connecting both regimes. The scaling is consistent with a number of sum rules in the large momentum limit. Furthermore, we derive an exact expression for the shift and width of the single-particle peak at large momentum due to interactions, thus extending a result by Beliaev [JETP 7, 299 (1958)] for the low-density Bose gas to arbitrary values of the scattering length $a$. The shift exhibits a maximum around $qa \simeq 1$, which is connected with a maximum in the static structure factor due to strong short-range correlations. For Bose gases with moderate interaction strengths, the theoretically predicted shift is consistent with the value observed by Papp et al. [Phys. Rev. Lett. 101, 135301 (2008)]. Finally, we develop a diagrammatic theory for the dynamic structure factor which accounts for the correlations beyond Bogoliubov theory and which covers the full range of momenta and frequencies, showing the correct asymptotic scaling at large momentum.
description: 23 pages, 11 figures
Synthesis, structural, spectral, antioxidant, bioactivity and molecular docking investigations of a novel triazole derivative
Creators: name: Alaşalvar, Can
name: Öztürk, Nuri
name: Gökce, Halil
name: Güder, Aytaç
name: Menteşe, Emre
name: Bektaş, Hakan
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: The structural, spectroscopic and electronic properties of 4-(4-nitrophenyl)-5-(pyridin-3-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione have been analyzed by using single crystal X-ray diffraction (SCXRD), 1H and 13C NMR chemical shifts and FT-IR spectroscopic methods both theoretically and experimentally. The tautomeric (thiol and thione) energetic analysis results, structural optimization parameters (bond lengths and angles), vibrational wavenumbers, proton and carbon NMR chemical shifts, UV-Vis. parameters, the highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) analyses and Molecular Electrostatic Potential (MEP) surface have been calculated by using DFT/B3LYP quantum chemical method with 6-311++G(2d,2p) basis set to compare with the experimental results. The computed geometry parameters, vibrational wavenumbers, and NMR chemical shifts have been in good agreement with the experimental results. It should be noted that the radical scavenging activities of the title compound have been evaluated by using different test methods i.e. 2,2-Diphenyl-1-picrylhydrazyl (DPPH), N,N-dimethyl-p-phenylenediamine (DMPD) and 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS). According to obtained results, the title compound displayed DPPH (SC50 19.42 ± 0.11 μg/mL), DMPD (SC50 21.13 ± 0.08 μg/mL) and ABTS (SC50 38.17 ± 0.25 μg/mL) scavenging activities. Also, these results have been compared with Butylated hydroxyanisole (BHA), Rutin (RUT) and Trolox (TRO) used as standard compounds. The physicochemical, pharmacokinetic, and toxicity features of the compound have been determined by using drug-likeness and in silico ADMET investigations. The interaction results with SARS-CoV-2 main protease (Mpro) of the title ligand compound have been analyzed via the help of molecular docking study. Communicated by Ramaswamy H. Sarma
STS, ITALIA
Creators: name: Bruni, Attila
Publisher: name: Tecnoscienza – Italian Journal of Science & Technology Studies
Year: 2013

description: What is the state of art of Science and Technology Studies in Italy? What happened in the last five years? In this paper, the departing President of STS Italia traces the main lines of research of STS scholars in Italy, highlighting the ways in which a scientific field (previously under-represented in the Italian scenario) has gained visibility and substance. In particular, the narration concentrates on the capacity of researchers to build research networks (at both national and inter- national level) actively contributing to the inter/national debate, as well as to ques- tion and innovate ways of thinking about technology and the social itself.
description: Tecnoscienza – Italian Journal of Science & Technology Studies, Vol. 3 No. 2 (2012): Tecnoscienza Nr. 6
Schmitz, Heribert: Die Liturgie-Instruktion Redemptionis Sacramentum von 2004
Creators: name: Rothe, Wolfgang F.
Publisher: name: Forum Katholische Theologie
Year: 1970

description: Forum Katholische Theologie, Bd. 24 Nr. 1 (2008): Forum Katholische Theologie, Band 24, Heft 1
Additional file 1 of Falls and falls-related injuries in individuals with chronic ankle symptoms: a cross-sectional study
Creators: name: Al Mahrouqi, Munira M.
name: Vicenzino, Bill
name: MacDonald, David A.
name: Smith, Michelle D.
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Neuroscience
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Mental Health

description: Additional file 1: Supplementary File 1. STROBE Statement – Checklist of items that should be included in reportsof observational studies.
Retargetable Generation of Code Selectors from HDL Processor Models
Creators: name: Leupers, Rainer
name: Marwedel, Peter
Publisher: name: Universität Dortmund
Year: 1998
Subjects: subject: 004

description: Besides high code quality, a primary issue in embedded code generation is retargetability of code generators. This paper presents techniques for automatic generation of code selectors from externally specified processor models. In contrast to previous work, our retargetable compiler RECORD does not require tool-specific modelling formalisms, but starts from general HDL processor models. From an HDL model, all processor aspects needed for code generation are automatically derived. As demonstrated by experimental results, short turnaround times for retargeting are achieved, which permits to study the HW/SW trade-off between processor architectures and program execution speed.
Propagation of Relativistic, Hydrodynamic, Intermittent Jets in a Rotating, Collapsing GRB Progenitor Star
Creators: name: Geng, Jin-Jun
name: Zhang, Bing
name: Kuiper, Rolf
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The prompt emission of gamma-ray bursts (GRBs) is characterized by rapid variabilities, which may be a direct reflection of the unsteady central engine. We perform a series of axisymmetric 2.5-dimensional simulations to study the propagation of relativistic, hydrodynamic, intermittent jets through the envelope of a GRB progenitor star. A realistic rapidly rotating star is incorporated as the background of jet propagation, and the star is allowed to collapse due to the gravity of the central black hole. By modeling the intermittent jets with constant-luminosity pulses with equal on and off durations, we investigate how the half-period, $T$, affects the jet dynamics. For relatively small $T$ values (e.g. 0.2 s), the jet breakout time $t_{\rm bo}$ depends on the opening angle of the jet, with narrower jets more penetrating and reaching the surface at shorter times. For $T \leq 1$ s, the reverse shock crosses each pulse before the jet penetrates through the stellar envelope. As a result, after the breakout of the first group of pulses at $t_{\rm bo}$, several subsequent pulses vanish before penetrating the star, causing a quiescent gap. For larger half-periods ($T=2.0, 4.0$ s), all the pulses can successfully penetrate through the envelope, since each pulse can propagate through the star before the reverse shock crosses the shell. Our results may interpret the existence of a weak precursor in many long GRBs, given that the GRB central engine injects intermittent pulses with half-period $T \leq 1$ s. The observational data seem to be consistent with such a possibility.
description: 19 pages, 15 figures, ApJ accepted
Amtliche Mitteilungen der Technischen Universität Dortmund Nr. 10/2008
Creators: name: (:Unkn) Unknown
Publisher: name: Technische Universität Dortmund
Year: 2008
Subjects: subject: 080

description: Dienstvereinbarung zum Schutz vor PCB – Belastungen in den Gebäuden GB IV und V, Campus Süd der Technischen Universität Dortmund
description: Amtliche Mitteilungen der Technischen Universität Dortmund ; 10, 2008