cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The intracellular microbial sensor NLRP4 directs Rho-actin signaling to facilitate Group A Streptococcus-containing autophagosome-like vacuole formation
Creators: name: Nozawa, Takashi
name: Aikawa, Chihiro
name: Minowa-Nozawa, Atsuko
name: Nakagawa, Ichiro
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Xenophagy, also known as antibacterial autophagy, functions as a crucial defense system that can utilize intracellular pattern recognition sensors, such as NLRP4, to recognize and selectively eliminate bacterial pathogens. However, little is known about how NLRP4 regulates xenophagy. Here, we report that NLRP4 binds ARHGDIA (Rho GDP dissociation inhibitor α) to regulate Rho GTPase signaling and facilitate actin-mediated xenophagy. Specifically, NLRP4 is recruited to Group A Streptococcus (GAS) and colocalizes with GAS-containing autophagosome-like vacuoles (GcAVs), where it regulates ARHGDIA-Rho GTPase recruitment to promote autophagosome formation. The interaction between NLRP4, ARHGDIA, and Rho GTPases is regulated by ARHGDIA Tyr156 phosphorylation, which acts as a gate to induce Rho-mediated xenophagy. Moreover, ARHGDIA and Rho GTPase are involved in actin-mediated ATG9A recruitment to phagophores, facilitating elongation to form autophagosomes. Collectively, these findings demonstrate that NLRP4 functions as a Rho receptor complex to direct actin dynamics regulating xenophagy.
Project Milou: Vision Based Autonomous Snowplow
Creators: name: Qian, Chude
name: Chen, Kaiyi
name: Huang, Ziyi
name: Borneman, Drew
Publisher: name: Zenodo
Year: 2020
Subjects: Autonomous Snowplow

description: This is the poster for poster presentation session at the 2020 ION Autonomous Snowplow Competition, hosted in Dunwoody College of Technology, Minneapolis, MN. Presented by Chude Qian (Frank), Kaiyi Chen (Kay).
Recensión: Cañizales, I.; E. Sánchez Rugeles & L. Rodríguez. 2019. Cocodrilo americano. Colección La Fauna. España: Artes Gráficas Palermo, 24 pp.
Creators: name: Seijas, Andrés E.
Publisher: name: Zenodo
Year: 2020
Subjects: Crocodylia, book review, Crocodylus acutus, Reptilia, zoology

description: Book review - Recensión
Abundant off-target edits from site-directed RNA editing can be reduced by nuclear localization of the editing enzyme
Creators: name: Vallecillo-Viejo, Isabel C.
name: Liscovitch-Brauer, Noa
name: Montiel-Gonzalez, Maria Fernanda
name: Eisenberg, Eli
name: Rosenthal, Joshua J. C.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Site-directed RNA editing (SDRE) is a general strategy for making targeted base changes in RNA molecules. Although the approach is relatively new, several groups, including our own, have been working on its development. The basic strategy has been to couple the catalytic domain of an adenosine (A) to inosine (I) RNA editing enzyme to a guide RNA that is used for targeting. Although highly efficient on-target editing has been reported, off-target events have not been rigorously quantified. In this report we target premature termination codons (PTCs) in messages encoding both a fluorescent reporter protein and the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein transiently transfected into human epithelial cells. We demonstrate that while on-target editing is efficient, off-target editing is extensive, both within the targeted message and across the entire transcriptome of the transfected cells. By redirecting the editing enzymes from the cytoplasm to the nucleus, off-target editing is reduced without compromising the on-target editing efficiency. The addition of the E488Q mutation to the editing enzymes, a common strategy for increasing on-target editing efficiency, causes a tremendous increase in off-target editing. These results underscore the need to reduce promiscuity in current approaches to SDRE.
Additional file 2 of Association of LIN28B polymorphisms with chronic hepatitis B virus infection
Creators: name: Han, Qunying
name: Sang, Jiao
name: Fan, Xiude
name: Wang, Xiaoyun
name: Zeng, Lu
name: Zhang, Xiaoge
name: Zhang, Kun
name: Li, Na
name: Lv, Yi
name: Liu, Zhengwen
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 2 Table S2. Hardy-Weinberg equilibrium of LIN28B rs314277, rs314280, rs369065 and rs7759938 genotypes.
Обструкция уретры через 7 лет после имплантации синтетической субуретральной петли TVT
Creators: name: Петров Сергей Борисович
name: Шкарупа Дмитрий Дмитриевич
name: Карнаухов Иван Владимирович
name: Карандашев Василий Кириллович
name: Шкарупа Екатерина Андреевна
Publisher: name: Журнал акушерства и женских болезней
Year: 2011
Subjects: ИНФРАВЕЗИКАЛЬНАЯ ОБСТРУКЦИЯ
УРОСЛИНГ
ПОЗАДИЛОННЫЙ СЛИНГ
ТРАНСОБТУРАТОРНЫЙ СЛИНГ
TVT

description: В статье представлен опыт лечения больной с выраженными симптомами инфравезикальной обструкции спустя 7 лет после имплантации синтетического субуретрального слинга TVT в позадилонном положении. Причиной описанного состояния явилось избыточное давление петли на мочеиспускательный канал. Было предпринято оперативное вмешательство в объеме иссечения субуретральной части слинга, уретролизиса с одномоментной имплантацией эндопротеза УроСлинг в трансобтураторном положении. В послеоперационном периоде была дополнительно назначена антибактериальная и антимускариновая терапия. В результате проведенного лечения инфравезикальная обструкция была полностью устранена с сохранением функции удержания мочи.
Lapidaire alphabétique
Creators: name: Philippe De Thaon (Probable)
name: Philippe De Thaon (Probable)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: Langue et littérature françaises médiévales

description: Texte en français médiéval. Date de composition : 1er tiers 12e s. (1100 - 1133), domaine : didactique, genre : lapidaire, forme : vers
description: Bibliographic citation: Philippe de Thaon (probable), Lapidaire alphabétique, édité par Paul Studer et Joan Evans, Paris, 1924. Publié en ligne par la Base de français médiéval, http://catalog.bfm-corpus.org/Lapidal. Dernière révision le 2009-10-21.
title: ADCO, Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.1 (début XIIIe siècle), Cart. 166 (11 H 64), 136 folios, f. 0134v
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.1 (début XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 166 (11 H 64), 136 folios, f. 0134v, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.1 (début XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 166 (11 H 64), 136 folios, f. 0134v, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
PAX5 gene as a novel methylation marker that predicts both clinical outcome and cisplatin sensitivity in esophageal squamous cell carcinoma
Creators: name: Kurimoto, Keisuke
name: Hayashi, Masamichi
name: Guerrero-Preston, Rafael
name: Koike, Masahiko
name: Mitsuro Kanda
name: Hirabayashi, Sho
name: Tanabe, Hiroshi
name: Takano, Nao
name: Iwata, Naoki
name: Niwa, Yukiko
name: Takami, Hideki
name: Kobayashi, Daisuke
name: Tanaka, Chie
name: Yamada, Suguru
name: Nakayama, Goro
name: Sugimoto, Hiroyuki
name: Fujii, Tsutomu
name: Michitaka Fujiwara
name: Kodera, Yasuhiro
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Therapeutic strategies for esophageal cancer largely depend on histopathological assessment. To select appropriate treatments for individual patients, we examined the background molecular characteristics of tumor malignancy and sensitivity to multidisciplinary therapy. Seventy-eight surgically-resected esophageal squamous cell carcinoma (ESCC) cases during 2001–2013 were examined. PAX5, a novel gene methylation marker in ESCC, was evaluated in the specimens, as methylation of this gene was identified as an extremely tumor-specific event in squamous cell carcinogenesis of head and neck. PAX5 methylation status was evaluated by quantitative MSP (QMSP) assays. Mean QMSP value was 15.7 (0–136.3) in ESCCs and 0.3 (0–8.6) in adjacent normal tissues (P < 0.001). The 78 cases were divided into high QMSP value (high QMSP, n = 26) and low QMSP value (low QMSP, n = 52). High QMSP cases were significantly associated with downregulated PAX5 expression (P = 0.040), and showed significantly poor recurrence-free survival [Hazard Ratio (HR) = 2.84; P = 0.005; 95% Confidence Interval (CI): 1.39–5.81] and overall survival (HR = 3.23; P = 0.002; 95%CI: 1.52–7.01) in multivariable analyses with histopathological factors. PAX5-knockdown cells exhibited significantly increased cell proliferation and cisplatin resistance. PAX5 gene methylation can predict poor survival outcomes and cisplatin sensitivity in ESCCs and could be a useful diagnostic tool for cancer therapy selection.
Facile sonochemical heterocyclization of 2,5-dimethoxy tetrahydrofuran with primary amines using sulfonated MWCNTs as a recyclable catalyst in aqueous media
Creators: name: Naeimi, Hossein
name: Mahla Dadaei
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified

description: A set of N-substituted pyrrole derivatives have been designed and synthesized using sulfonated multi-walled carbon nanotubes as a recyclable heterogeneous catalyst under ultrasound irradiation. This reaction was carried out between 2,5-dimethoxy tetrahydrofuran and primary amines in water under green conditions. This method has some advantages such as: short reaction times, excellent product yields, simplicity of the procedure, easy work-up and high purity of products.
MTOR signaling is essential for the development of thymic epithelial cells and the induction of central immune tolerance
Creators: name: Zhanfeng Liang
name: Lianjun Zhang
name: Huiting Su
name: Luan, Rong
name: Na, Ning
name: Sun, Lina
name: Zhao, Yang
name: Xiaodong Zhang
name: Zhang, Qian
name: Li, Juan
name: Lianfeng Zhang
name: Zhao, Yong
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: Thymic epithelial cells (TECs) are critical for the establishment and maintenance of appropriate microenvironment for the positive and negative selection of thymocytes and the induction of central immune tolerance. Yet, little about the molecular regulatory network on TEC development and function is understood. Here, we demonstrate that MTOR (mechanistic target of rapamycin [serine/threonine kinase]) is essential for proper development and functional maturation of TECs. Pharmacological inhibition of MTOR activity by rapamycin (RPM) causes severe thymic atrophy and reduction of TECs. TEC-specific deletion of Mtor causes the severe reduction of mTECs, the blockage of thymocyte differentiation and output, the reduced generation of thymic regulatory T (Treg) cells and the impaired expression of tissue-restricted antigens (TRAs) including Fabp2, Ins1, Tff3 and Chrna1 molecules. Importantly, specific deletion of Mtor in TECs causes autoimmune diseases characterized by enhanced tissue immune cell infiltration and the presence of autoreactive antibodies. Mechanistically, Mtor deletion causes overdegradation of CTNNB1/Beta-Catenin due to excessive autophagy and the attenuation of WNT (wingless-type MMTV integration site family) signaling in TECs. Selective inhibition of autophagy significantly rescued the poor mTEC development caused by Mtor deficiency. Altogether, MTOR is essential for TEC development and maturation by regulating proliferation and WNT signaling activity through autophagy. The present study also implies that long-term usage of RPM might increase the risk of autoimmunity by impairing TEC maturation and function.
Measurement of local crystal lattice strain variations in dealloyed nanoporous gold
Creators: name: Mahr, Christoph
name: Müller-Caspary, Knut
name: Graf, Matthias
name: Lackmann, Anastasia
name: Grieb, Tim
name: Schowalter, Marco
name: Krause, Florian F.
name: Mehrtens, Thorsten
name: Wittstock, Arne
name: Weissmüller, Jörg
name: Rosenauer, Andreas
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Reversible macroscopic length changes in nanoporous structures can be achieved by applying electric potentials or by exposing them to different gases or liquids. Thus, these materials are interesting candidates for applications as sensors or actuators. Macroscopic length changes originate from microscopic changes of crystal lattice parameters. In this report, we show spatially resolved measurements of crystal lattice strain in dealloyed nanoporous gold. The results confirm theory by indicating a compression of the lattice along the axis of cylindrically shaped ligaments and an expansion in radial direction. Furthermore, we show that curved npAu surfaces show inward relaxation of the surface layer. IMPACT STATEMENT We show spatially resolved measurements of strain in nanoporous gold confirming theory: Crystal lattice is compressed along the axis of cylindrical ligaments and expanded in radial direction, surfaces relax inward.
title: ADCO, Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Cart. 32 (G 136), 745 folios, f. 1133
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire

description: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 1133, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 1133, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome I, Cart. 185 (11 H 70), f. 01
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome I, Archives départementales de la Côte-d'Or, Cart. 185 (11 H 70), f. 01, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome I, Archives départementales de la Côte-d'Or, Cart. 185 (11 H 70), f. 01, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Diamond Open Access: the Action Plan and the overlay journal platform EPISCIENCES
Creators: name: Tournoy, Raphaël
name: Barthonnat, Céline
name: Legrand, Mathias
name: Saenen, Bregt
Publisher: name: Zenodo
Year: 2022
Subjects: OpenAIRE
Episciences
Overlay journal platform
Action Plan for Diamond Open Access
Diamond Open Access
OpenAIRE services

description: OpenAIRE Webinar, 29th March, 2022 This OpenAIRE public webinar aimed to present the Episciences platform and associated services as well the use case of JTCAM overlay journal. It was also an opportunity to present the Action Plan for Diamond Open Access. Episciences is a complete platform for editing and publishing scientific overlay journals covering all disciplines. An overlay journal is a scientific journal, with a unique editorial line and publication project, which relies on a diamond Open Access evaluation and publication platform. An Episciences overlay journal has a complete publishing system on its own site which allows it to manage both the editorial workflow and the publication of articles. Know more about Episciences here. PROGRAMME: Presentation of the publishing platform and associated services
 Raphaël Tournoy, Céline Barthonnat, CNRS Feedback and experience from the JTCAM overlay journal
 Mathias Legrand, McGill University Action Plan for Diamond Open Access
 Bregt Saenen, Science Europe Webinar recording: https://youtu.be/I2mBTkMepWI
Excellent corrosion resistance and hardness in Al alloys by extended solid solubility and nanocrystalline structure
Creators: name: J. Esquivel
name: H. A. Murdoch
name: K. A. Darling
name: R. K. Gupta
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Development of ultra-high strength and corrosion-resistant aluminum (Al) alloys is demonstrated by a combination of suitable alloying elements and processing technology able to cause extended solid solubility and nanocrystalline structure. Binary Al-transition metal (M: Cr, Ni, Mo, Si, Ti, Mn, V, Nb) alloys, produced by high-energy ball milling and subsequent cold compaction, have exhibited significantly high hardness and corrosion resistance compared to any commercial Al alloy. The cyclic potentiodynamic polarization tests revealed a significant improvement in pitting and repassivation potentials. X-ray diffraction analysis revealed the grain refinement <100 nm and extended solid solubility. IMPACT STATEMENT High-energy ball-milled Al alloys, owing to excellent corrosion resistance and high hardness, are expected to be a new class of Al alloys and initiate a multidisciplinary research direction.
title: From Valid Measurements to Valid Mini-Apps
Creators: name: Lehr, Jan-Patrick
Publisher: name: UNSPECIFIED
Year: 2022

description: In high-performance computing, performance analysis, tuning, and exploration are relevant throughout the life cycle of an application. State-of-the-art tools provide capable measurement infrastructure, but they lack automation of repetitive tasks, such as iterative measurement-overhead reduction, or tool support for challenging and time-consuming tasks, e.g., mini-app creation. In this thesis, we address this situation with (a) a comparative study on overheads introduced by different tools, (b) the tool PIRA for automatic instrumentation refinement, and (c) a tool-supported approach for mini-app extraction. In particular, we present PIRA for automatic iterative performance measurement refinement. It performs whole-program analysis using both source-code and runtime information to heuristically determine where in the target application measurement hooks should be placed for a low-overhead assessment. At the moment, PIRA offers a runtime heuristic to identify compute-intensive parts, a performance-model heuristic to identify scalability limitations, and a load imbalance detection heuristic. In our experiments, PIRA compared to Score-P’s built-in filtering significantly reduces the runtime overhead in 13 out of 15 benchmark cases and typically introduces a slowdown of < 10 %. To provide PIRA with the required infrastructure, we develop MetaCG — an extendable lightweight whole-program call-graph library for C/C++. The library offers a compiler-agnostic call-graph (CG) representation, a Clang-based tool to construct a target’s CG, and a tool to validate the structure of the MetaCG. In addition to its use in PIRA, we show that whole-program CG analysis reduces the number of allocation to track by the memory tracking sanitizer TypeART by up to a factor of 2,350×. Finally, we combine the presented tools and develop a tool-supported approach to (a) identify, and (b) extract relevant application regions into representative mini-apps. Therefore, we present a novel Clang-based source-to-source translator and a type-safe checkpoint-restart (CPR) interface as a common interface to existing MPI-parallel CPR libraries. We evaluate the approach by extracting a mini-app of only 1,100 lines of code from an 8.5 million lines of code application. The mini-app is subsequently analyzed, and maintains the significant characteristics of the original application’s behavior. It is then used for tool-supported parallelization, which led to a speed-up of 35 %. The software presented in this thesis is available at https://github.com/tudasc.
Additional file 2 of Rv3737 is required for Mycobacterium tuberculosis growth in vitro and in vivo and correlates with bacterial load and disease severity in human tuberculosis
Creators: name: Li, Qing
name: Peng, Zhangli
name: Fu, Xuefeng
name: Wang, Hong
name: Zhao, Zhaoliang
name: Pang, Yu
name: Chen, Ling
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2: Table S1. Bacterial strains, plasmids and cells used in this study.
Synthesis and in vitro antiproliferative and antibacterial activity of new thiazolidine-2,4-dione derivatives
Creators: name: Trotsko, Nazar
name: Przekora, Agata
name: Zalewska, Justyna
name: Grażyna Ginalska
name: Paneth, Agata
name: Wujec, Monika
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Hematology
subject: 60506 Virology

description: In our present research, we synthesised new thiazolidine-2,4-diones (12–28). All the newly synthesised compounds were evaluated for antiproliferative and antibacterial activity. Antiproliferative evaluation was carried out using normal human skin fibroblasts and tumour cell lines: A549, HepG2, and MCF-7. The IC50 values were determined for tested compounds revealing antiproliferative activity. Moreover, safety index (SI) was calculated. Among all tested derivatives, the compound 18 revealed the highest antiproliferative activity against human lung, breast, and liver cancer cells. More importantly, the derivative 18 showed meaningfully lower IC50 values when compared to the reference substance, irinotecan, and relatively high SI values. Moreover, newly synthesised compounds were screened for the bacteria growth inhibition in vitro. According to our screening results, most active compound was the derivative 18 against Gram-positive bacteria. Therefore, it may be implied that the novel compound 18 appears to be a very promising agent for anticancer treatment.
Diaryl ethers with carboxymethoxyphenacyl motif as potent HIV-1 reverse transcriptase inhibitors with improved solubility
Creators: name: Frączek, Tomasz
name: Rafał Kamiński
name: Krakowiak, Agnieszka
name: Naessens, Evelien
name: Verhasselt, Bruno
name: Paneth, Piotr
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: In search of new non-nucleoside reverse transcriptase inhibitors (NNRTIs) with improved solubility, two series of novel diaryl ethers with phenacyl moiety were designed and evaluated for their HIV-1 reverse transcriptase inhibition potentials. All compounds exhibited good to excellent results with IC50 at low micromolar to submicromolar concentrations. Two most active compounds (7e and 7 g) exhibit inhibitory potency comparable or even better than that of nevirapine and rilpivirine. Furthermore, SupT1 and CD4+ cell infectivity assays for the most promising (7e) have confirmed its strong antiviral potential while docking studies indicate a novel binding interactions responsible for high activity.
Migrant Network and Immigrants’ Occupational Mismatch
Creators: name: Chort, Isabelle
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: This article defines new measures of horizontal and vertical occupational mismatch based on the difference between the skill content of occupations in which individuals have a self-assessed productive advantage, and that of their actual job. It then investigates the impact of network use to find a job on occupational mismatch in the case of immigrants, using original survey data collected among Senegalese immigrants in four host countries. Estimation results show that migrants who obtained their job through the migrant network have a lower probability of negative vertical mismatch. By contrast, network use is not found to significantly affect horizontal mismatch.
Additional file 1 of Transcriptome Sequencing and iTRAQ of Different Rice Cultivars Provide Insight into Molecular Mechanisms of Cold-Tolerance Response in Japonica Rice
Creators: name: Jia, Yan
name: Liu, Hualong
name: Qu, Zhaojun
name: Wang, Jin
name: Wang, Xinpeng
name: Wang, Zhuoqian
name: Yang, Liang
name: Zhang, Dong
name: Zou, Detang
name: Zhao, Hongwei
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Table S1. Summary of the RNA-Seq paired-end data produced by Illumina sequencing. Table S2. Significant KEGG pathways of DEGs (P-value ≤0.05) involved in DN and SJ under low-Tw treatment. Table S3. Significant KEGG pathways of the DEPs (P-value ≤0.05) involved in DN and SJ under low-Tw treatment. Table S4. A list of significantly enriched GO terms (P-value ≤0.05) with DEGs in DN and SJ under low-Tw treatment. Table S5. A list of significantly enriched GO terms (P-value ≤0.05) with DEPs in DN and SJ under low-Tw treatment. Table S6. A detailed list of the TFs expressed differentially in CKDN vs. D15DN under low-Tw treatment. Table S7. A detailed list of the TFs expressed differentially in CKSJ vs. D15SJ under low-Tw treatment.
Magneto-Thermal Thin Shell Approximation for 3D Finite Element Analysis of No-Insulation Coils
Creators: name: Schnaubelt, Erik
name: Atalay, Sina
name: Wozniak, Mariusz
name: Dular, Julien
name: Geuzaine, Christophe
name: Vanderheyden, Benoît
name: Marsic, Nicolas
name: Verweij, Arjan
name: Schöps, Sebastian
Publisher: name: arXiv
Year: 2023
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: Superconductivity (cond-mat.supr-con)
subject: Computational Engineering, Finance, and Science (cs.CE)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: For finite element (FE) analysis of no-insulation (NI) high-temperature superconducting (HTS) pancake coils, the high aspect ratio of the turn-to-turn contact layer (T2TCL) leads to meshing difficulties which result in either poor quality mesh elements resulting in a decrease of the solution accuracy or a high number of degrees of freedom. We proposed to mitigate this issue by collapsing the T2TCL volume into a surface and using a so-called thin shell approximation (TSA). Previously, two TSA have been introduced, one to solve the heat equation and the other for an $\vec{H}-ϕ$ magnetodynamic formulation.
 In this work, we propose to combine the magnetodynamic and thermal TSA to create a coupled magneto-thermal TSA for three-dimensional FE analysis. Particular attention is paid to the detailed derivation of the coupling terms. In the context of NI HTS pancake coils, the TSA represents the electric and thermal contact resistance of the T2TCL. For the HTS coated conductor (CC) itself, an anisotropic homogenization is used which represents its multi-layered structure. In axial and azimuthal direction, it resolves the current sharing between the HTS and other layers of the CC. The coupled TSA formulation is verified against a reference model with volumetric T2TCL. The coupled TSA is shown to significantly reduce the solution time as well as the manual effort required for high-quality meshes of the T2TCL. The implementation is open-source and a reference implementation is made publicly available.
description: Presented at EUCAS 2023, Bologna, Italy. This work has been submitted to the IEEE for possible publication
title: ADCO, Deuxième cartulaire ou Grand cartulaire de l'abbaye de Molesme, Cart. 143 (7 H 7), 153 fol, f. 0011r
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2009
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Deuxième cartulaire ou Grand cartulaire de l'abbaye de Molesme, Archives départementales de la Côte-d'Or, Cart. 143 (7 H 7), 153 fol, f. 0011r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Deuxième cartulaire ou Grand cartulaire de l'abbaye de Molesme, Archives départementales de la Côte-d'Or, Cart. 143 (7 H 7), 153 fol, f. 0011r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb137389344
description: Provenance: abbaye de Molesme
description: Provenance: http://www.wikidata.org/entity/Q334044
Asymptotics of Solutions to Silent Wave Equations
Creators: name: Grisales, Andrés Franco
Publisher: name: arXiv
Year: 2023
Subjects: subject: Analysis of PDEs (math.AP)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We study the asymptotics of solutions to a particular class of systems of linear wave equations, namely, of silent equations. We obtain asymptotic estimates of all orders for the solutions, and show that solutions are uniquely determined by the asymptotic data contained in the estimates. As an application, we then study solutions to the source free Maxwell's equations in Kasner spacetimes near the initial singularity. Our results allow us to obtain an asymptotic expansion for the potential of the electromagnetic field, and to show that the energy density of generic solutions blows up along generic timelike geodesics when approaching the singularity. The asymptotics we study correspond to the heuristics of the BKL conjecture, where the coefficients of the spatial derivative terms of the equations are expected to be small, and thus these terms are neglected in order to obtain the asymptotics.
description: 53 pages. This version corresponds to the published version
Marcanine G, a new cytotoxic 1-azaanthraquinone from the stem bark of Goniothalamus marcanii Craib
Creators: name: Pongpol Thanuphol
name: Asami, Yukihiro
name: Kazuro Shiomi
name: Ariyaphong Wongnoppavich
name: Patoomratana Tuchinda
name: Noppamas Soonthornchareonnon
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Plant Biology

description: The ethanolic extract from the stem bark of Goniothalamus marcanii Craib was shown in preliminary brine shrimp lethality data having good cytotoxic activity. Further bioassay guided isolation was done by means of solvent partition, chromatography and precipitation to provide four isolated compounds: a novel compound 1 with the core structure of 1-azaanthraquinone moiety referred as marcanine G; as well as compounds 2–4 with known aristolactam structures namely, piperolactam C, cepharanone B and taliscanine. These compounds were characterised by spectroscopic techniques. The assessment of cytotoxicity was established on an SRB assay using doxorubicin as a positive control. Marcanine G (1) was considered the most active compound indicating the IC50 values of 14.87 and 15.18 μM against human lung cancer cells (A549) and human breast cancer cells (MCF7), respectively. However, 2 showed mild activity with the IC50 values of 83.72 and 82.32 μM against A549 and MCF7 cells, respectively.
Project Raptor: An Autonomous Vehicle Platform
Creators: name: Qian, Chude
name: Schmidt, James
name: Gallishen, Christina
Publisher: name: Zenodo
Year: 2019
Subjects: Autonomous Vehicles Platform
PowerWheels

description: This is the poster for describing the senior capstone project: Project Raptor. The poster presentation was given in April 2019 at Case Western Reserve University Intersection. Presented by Chude Qian, James Schmidt, and Christina Gallishen. The Project has won the best senior project for 2019.
Self-injective algebras under derived equivalences
Creators: name: Xi, Changchang
name: Zhang, Jin
Publisher: name: arXiv
Year: 2023
Subjects: subject: Representation Theory (math.RT)
subject: Rings and Algebras (math.RA)
subject: FOS: Mathematics
subject: Primary 18G80, 16E35, 16D50, Secondary 16G10, 18F30, 16P10

description: The Nakayama permutations of two derived equivalent, self-injective Artin algebras are conjugate. A different but elementary approach is given to showing that the weak symmetry and self-injectivity of finite-dimensional algebras over an arbitrary field are preserved under derived equivalences.
description: 11 pages. Corollary 5.5 is reformulated
title: Quadriceps fat-pad impingement syndrome with focal tendinosis of the distal quadriceps tendon
Creators: name: Munday, Charlotte Elizabeth
Publisher: name: EURORAD
Year: 2022
Subjects: subject: Musculoskeletal system
subject: Musculoskeletal joint
subject: Musculoskeletal soft tissue
subject: MR
subject: Clinical Cases

description: Clinical History: A 27-year-old female presented with an 8-month history of anterior knee pain. The patient denied any history of preceding trauma/infection. Past medical history included SLE (systemic lupus erythematous). Clinical examination revealed restricted range of motion of the knee limited by pain however no joint effusion, focal tenderness or ligamentous laxity. 

description: 27 years, female
title: ADCO, Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Cart. 32 (G 136), 745 folios, f. 0170
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 0170, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 0170, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Additional file 4 of Association of LIN28B polymorphisms with chronic hepatitis B virus infection
Creators: name: Han, Qunying
name: Sang, Jiao
name: Fan, Xiude
name: Wang, Xiaoyun
name: Zeng, Lu
name: Zhang, Xiaoge
name: Zhang, Kun
name: Li, Na
name: Lv, Yi
name: Liu, Zhengwen
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 4 Table S4. Allele frequencies of LIN28B rs314277, rs314280, rs369065 and rs7759938 in patients with chronic HBV infection, infection resolvers and healthy controls.
Computation-Limited Signals: A Channel Capacity Regime Constrained by Computational Complexity
Creators: name: Queiroz, Saulo
name: Vilela, João P.
name: Monteiro, Edmundo
Publisher: name: arXiv
Year: 2023
Subjects: subject: Information Theory (cs.IT)
subject: Computational Complexity (cs.CC)
subject: Signal Processing (eess.SP)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In this letter, we introduce the computational-limited (comp-limited) signals, a communication capacity regime in which the signal time computational complexity overhead is the key constraint -- rather than power or bandwidth -- to the overall communication capacity. We present the Spectro-Computational (SC) analysis, a novel mathematical framework that enhances classic concepts of information theory -- such as throughput, spectral efficiency and capacity -- to account for the signal processing computational complexity overhead. We consider a specific Shannon regime under which capacity is expected to get arbitrarily large as channel resources grow. Under that regime, we identify the conditions under which the time complexity overhead causes capacity to decrease rather than increasing, thereby creating the case for the comp-limited regime. We also provide examples of the SC analysis and show the OFDM waveform is comp-limited unless the lower-bound computational complexity of the $N$-point DFT problem verifies as $Ω(N)$, which remains an open challenge.
description: This work has been submitted to the IEEE for possible publication
Additional file 3 of Transcriptome Sequencing and iTRAQ of Different Rice Cultivars Provide Insight into Molecular Mechanisms of Cold-Tolerance Response in Japonica Rice
Creators: name: Jia, Yan
name: Liu, Hualong
name: Qu, Zhaojun
name: Wang, Jin
name: Wang, Xinpeng
name: Wang, Zhuoqian
name: Yang, Liang
name: Zhang, Dong
name: Zou, Detang
name: Zhao, Hongwei
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3: Figure S1. Spearman correlations for the proteins and corresponding genes in each group.
High-dose immunosuppression to prevent death after paraquat self-poisoning – a randomised controlled trial
Creators: name: Indika Gawarammana
name: Buckley, Nicholas A.
name: Mohamed, Fahim
name: Naser, Kamal
name: K. Jeganathan
name: P. L. Ariyananada
name: Klintean Wunnapuk
name: Dobbins, Timothy A.
name: Tomenson, John A.
name: Wilks, Martin F.
name: Eddleston, Michael
name: Dawson, Andrew H.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: Context: Intentional self-poisoning with the herbicide paraquat has a very high case-fatality and is a major problem in rural Asia and Pacific. Objectives: We aimed to determine whether the addition of immunosuppression to supportive care offers benefit in resource poor Asian district hospitals. Materials and methods: We performed a randomised placebo-controlled trial comparing immunosuppression (intravenous cyclophosphamide up to 1 g/day for two days and methylprednisolone 1 g/day for three days, and then oral dexamethasone 8 mg three-times-a-day for 14 days) with saline and placebo tablets, in addition to standard care, in patients with acute paraquat self-poisoning admitted to six Sri Lankan hospitals between 1st March 2007 and 15th November 2010. The primary outcome was in-hospital mortality. Results: 299 patients were randomised to receive immunosuppression (147) or saline/placebo (152). There was no significant difference in in-hospital mortality rates between the groups (immunosuppression 78 [53%] vs. placebo 94 [62%] (Chi squared test 2.4, p = .12). There was no difference in mortality at three months between the immunosuppression (101/147 [69%]) and placebo groups (108/152 [71%]); (mortality reduction 2%, 95% CI: −8 to +12%). A Cox model did not support benefit from high-dose immunosuppression but suggested potential benefit from the subsequent two weeks of dexamethasone. Conclusions: We found no evidence that high dose immunosuppression improves survival in paraquat-poisoned patients. The continuing high mortality means further research on the use of dexamethasone and other potential treatments is urgently needed.
title: ADCO, Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.2 (2e moitié XIIIe siècle), Cart. 167 (11 H 67), f. 0036r
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2010
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.2 (2e moitié XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 167 (11 H 67), f. 0036r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de l'abbaye de Cîteaux dit Cartulare Antiquum t.2 (2e moitié XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 167 (11 H 67), f. 0036r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Additional file 4 of Transcriptome Sequencing and iTRAQ of Different Rice Cultivars Provide Insight into Molecular Mechanisms of Cold-Tolerance Response in Japonica Rice
Creators: name: Jia, Yan
name: Liu, Hualong
name: Qu, Zhaojun
name: Wang, Jin
name: Wang, Xinpeng
name: Wang, Zhuoqian
name: Yang, Liang
name: Zhang, Dong
name: Zou, Detang
name: Zhao, Hongwei
Publisher: name: figshare
Year: 2020
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 4: Figure S2. Targeted gene analysis of the TFs.