cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Optimal Uncertainty Relations for Extremely Coarse-grained Measurements
Creators: name: Rudnicki, Łukasz
name: Walborn, Stephen P.
name: Toscano, Fabricio
Publisher: name: arXiv
Year: 2012
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We derive two quantum uncertainty relations for position and momentum coarse-grained measurements. Building on previous results, we first improve the lower bound for uncertainty relations using the Renyi entropy, particularly in the case of coarse-grained measurements. We then sharpen a Heisenberg-like uncertainty relation derived previously in [Europhys. Lett. 97, 38003, (2012)] that uses variances and reduces to the usual one in the case of infinite precision measurements. Our sharpened uncertainty relation is meaningful for any amount of coarse graining. That is, there is always a non-trivial uncertainty relation for coarse-grained measurement of the non-commuting observables, even in the limit of extremely large coarse graining.
QSAR-driven rational design of novel DNA methyltransferase 1 inhibitors
Creators: name: Phanus-Umporn, Chuleeporn
name: Prachayasittikul, Veda
name: Nantasenamat, Chanin
name: Prachayasittikul, Supaluk
name: Prachayasittikul, Virapong
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2020
Subjects: subject: DNA methyltransferase 1
subject: QSAR
subject: Computer-aided drug design
subject: Rational design
subject: Structural modification
subject: Epigenetic modulators
subject: 610

description: DNA methylation, an epigenetic modification, is mediated by DNA methyltransferases (DNMTs), a family of enzymes. Inhibitions of these enzymes are considered a promising strategy for the treatment of several diseases. In this study, a quantitative structure-activity relationship (QSAR) modeling was employed to understand the structure-activity relationship (SAR) of currently available non-nucleoside DNMT1 inhibitors (i.e., indole and oxazoline/1,2-oxazole scaffolds). Two QSAR models were successfully constructed using multiple linear regression (MLR) and provided good predictive performance (R2Tr = 0.850-0.988 and R2CV = 0.672-0.869). Bond information content index (BIC1) and electronegativity (R6e+) are the most influential descriptors governing the activity of compounds. The constructed QSAR models were further applied for guiding a rational design of novel inhibitors. A novel set of 153 structurally modified compounds were designed in silico according to the important descriptors deduced from the QSAR finding, and their DNMT1 inhibitory activities were predicted. This result demonstrated that 86 newly designed inhibitors were predicted to elicit enhanced DNMT1 inhibitory activity when compared to their parent compounds. Finally, a set of promising compounds as potent DNMT1 inhibitors were highlighted to be further developed. The key SAR findings may also be beneficial for structural optimization to improve properties of the known inhibitors.
description: EXCLI Journal;Vol. 19 2020
Ein Beitrag zur viskoelastischen Modellierung nichtholonomer Bindungsgleichungen
Creators: name: Deppler, Jens
Publisher: name: Karlsruhe
Year: 2016

description: Es wird eine Methode zur Modellierung elastischer Wälzkontakte vorgeschlagen. Die Konvergenz gegen die ideal starre Formulierung wird bewiesen. In ein bestehendes Kontaktmodell für einen flächigen Reibkontakt wird das Wälzmodell integriert. Es beinhaltet auf natürliche Weise Roll- und Bohrreibung. An einigen Beispielen aus der Biomechanik und dem Automotive Sektor wird die Anwendbarkeit und Effizienz der vorgeschlagenen Methode demonstriert.
Community life and governance : early experiences of Mnjikaning First Nation with Casino Rama
Creators: name: Campbell, Karen, 1971-
Publisher: name: National Library of Canada
Year: 1999
Subjects: subject: Casinos--Economic aspects--Canada
subject: Casinos--Social aspects
subject: Gambling--Economic aspects
subject: Gambling--Social aspects
subject: Gambling Literature

description: Casino gambling offers large profits to support self-government and economic self-sufficiency for First Nations communities. Casinos also increase the number of problem gamblers, redistribute money from families with low and moderate incomes, and exacerbate community divisions and cultural conflicts. This qualitative study explores the experiences of Mnjikaning (Rama) First Nation, approximately one year after it opened the largest Native casino in Canada. Primary data are from fifty-three formal interviews, conducted from July to October 1997, and informal discussions between June 1994 and September 1998. The report focuses on how the casino affected community life and governance. Casino development gave Rama increased employment, new buildings and more social and administrative services. It has also been extremely disruptive, with increased traffic, many more strangers in the community, and a greater incidence of gambling problems among community members. The casino's considerable influence over communitydecisions and priorities has serious implications for future self-government processes. There are many lessons to be learned from Rama's experience for other First Nations communities that are considering casino development. Most important is to make explicit the negative impacts associated with casino development, and to ensure the community is able to retain a measure of control over the project.
title: Association between HIC1 promoter methylation and solid tumor
title: a meta-analysis
titleType: AlternativeTitle
Creators: name: Zhao, Tie
name: Afrifa, Justice
name: Wang, Dong
name: Yu, Jingcui
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2020
Subjects: subject: HIC1
subject: Hypermethylation
subject: Tumor suppressor gene
subject: 610

description: The epigenetic silencing of tumor suppressor genes by promoter methylation plays an increasingly important role in cancer research. A number of studies have reported the contribution of HIC1 promoter methylation towards the occurrence and development of solid tumors, even though HIC1 promoter methylation has also been found in normal and benign tissue samples. We sought to perform a more accurate and comprehensive meta-analysis to assess the association between HIC1 promoter methylation and cancer risk. We searched and retrieved all published studies on HIC1 promoter methylation in PubMed, Google Scholar, Embase, Cochrane Library, and Web of Science databases. After two reviewers checked the studies and extracted the necessary data independently, the meta-analysis was performed using STATA 12.0 software. A total of 14 case-control studies (949 cancer patients, 282 benign, and 371 normal controls) were included in our study. We report a significantly elevated HIC1 promoter methylation in tumor samples compared to normal (OR = 7.02, 95 % CI 3.12-15.78, P < 0.001) and benign controls (OR = 2.69, 95 % CI 1.13-6.42, P = 0.025). Subgroup analysis stratified by ethnicity showed a significantly reduced heterogeneity among North American (I2 = 0.0 %, P = 0.502) and European (I2 = 33.7 %, P = 0.183) samples. In addition, heterogeneity was significantly reduced among MSP based detection method (I2= 36.4 %, P = 0.139) when samples were stratified based on the methylation detection methods. The overall outcome demonstrated that HIC1 promoter methylation may be involved in the occurrence and development of solid tumors and has the potential to serve as an epigenetic maker in various specific tumors.
description: EXCLI Journal;Vol. 19 2020
Bell Inequality Tests with Macroscopic Entangled States of Light
Creators: name: Stobińska, Magdalena
name: Sekatski, Pavel
name: Buraczewski, Adam
name: Gisin, Nicolas
name: Leuchs, Gerd
Publisher: name: arXiv
Year: 2011
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum correlations may violate the Bell inequalities. Most of the experimental schemes confirming this prediction have been realized in all-optical Bell tests suffering from the detection loophole. Experiment which closes this loophole and the locality loophole simultaneously is highly desirable and remains challenging. A novel approach to a loophole-free Bell tests is based on amplification of the entangled photons, i.e.\@ on macroscopic entanglement, which optical signal should be easy to detect. However, the macroscopic states are partially indistinguishable by the classical detectors. An interesting idea to overcome these limitations is to replace the postselection by an appropriate preselection immediately after the amplification. This is in the spirit of state preprocessing revealing hidden nonlocality. Here, we examine one of possible preselections, but the presented tools can be used for analysis of other schemes. Filtering methods making the macroscopic entanglement useful for Bell test and quantum protocols are the subject of an intensive study in the field nowadays.
description: 4 pages
ผลของโปรแกรมการออกกำลังกายแบบหายใจลึก ช้า ต่อความดันโลหิตและความแปรปรวนของอัตราการเต้นของหัวใจในผู้ใหญ่ไทย
Creators: name: จิรวัฒน์ วัฒนปัญญาเวชช์
Publisher: name: University of Phayao
Year: 2021
Subjects: การออกกำลังกายด้วยการหายใจ
ความดันโลหิต
ความแปรปรวนของอัตราการเต้นของหัวใจ

description: Naresuan Phayao Journal, 14, 2, 62-70
title: The neural basis of hazard perception differences between novice and experienced drivers
title: an fMRI study
titleType: AlternativeTitle
Creators: name: Gharib, Seifollah
name: Zare-Sadeghi, Arash
name: Zakerian, Seyed Abolfazl
name: Haidari, Mohsen Reza
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2020
Subjects: subject: Hazard perception skill
subject: fMRI
subject: Novice drivers
subject: Experienced drivers
subject: 610

description: The neural mechanisms underlying hazard perception are poorly understood as to how experience affects it in drivers. In this study we used functional magnetic resonance imaging (fMRI) to examine experienced-related changes in brain activation of a hazard perception skill between novice and aged drivers. Additionally, region of interest (ROI) and seed-to-voxel analysis were conducted to examine experienced-related functional connectivity changes in visual attention and saliency networks between novice (n=15, age 22.13± 3.38 years years) and experienced (n=16, age 41.44± 5.83 years) drivers. Experienced drivers had significantly lower hazard perception reaction time (1.32 ± 1.09 s) and miss rates (11.42 ± 8.36 %) compared to the novice (3.58± 1.45 s and 39.67 ± 15.72 %, respectively). Blood oxygen level dependent (BOLD) activation increased in occipital, parietal and frontal areas when executing hazard perception task in the both the groups. During task execution, experienced drivers showed, in general, greater activation in occipital lobe, Supramarginal Gyrus (SMG), right insular cortex, and anterior cingulate cortex (ACC) and cerebellar regions compared to the novice drivers indicating more efficient visual attention and decision-making processing in hazard perception skill. Seed based functional analyses in the task revealed greater connectivity between the ACC and the entire salience network (visual attention network) in the experienced group. Additionally, ACC had higher functional connectivity with right frontal eye field (FEF) and, bilateral Intraparietal Sulcus (IPS) and lateral occipital areas in the experienced group. Our results suggest that the hazard perception ability in experienced drivers is due to increase in the activation of executive attention regions, and better functional connectivity between bilateral occipital cortices and salience network. Better hazard perception performance is highly dependent on emotional awareness and attention to the velocity of motion.
description: EXCLI Journal;Vol. 19 2020
คุณสมบัติในการต้านอนุมูลอิสระและการยับยั้งเอนไซม์แอลฟากลูโคซิเดสในหลอดทดลองของสารสกัดจากเห็ดที่บริโภคได้
Creators: name: คคนางค์ รัตนานิคม
Publisher: name: University of Phayao
Year: 2021
Subjects: เห็ด
แอลฟากลูโคซิเดส
โรคเบาหวาน
การต้านอนุมูลอิสระ
ปริมาณสารประกอบฟีนอลิก

description: Naresuan Phayao Journal, 14, 2, 71-82
title: The impact of gaming upon Canadian non profits : a 1999 survey of gaming grant recipients
title: 1999 survey of gaming grant recipients
titleType: AlternativeTitle
Creators: name: Berdahl, Loleen Youngman
Publisher: name: Canada West Foundation
Year: 1999
Subjects: subject: Gambling -- Economic aspects -- Canada
subject: Nonprofit organizations -- Canada -- Finance
subject: Fund raising -- Canada
subject: Federal aid to nonprofit organizations -- Canada
subject: Grants-in-aid -- Canada
subject: Gambling Literature

description: Interest in the Canadian non-profit sector has increased dramatically in recent years. As governments download services and reduce government-run programs, the number of non- profit organizations grows. This raises questions about the role and importance of the non- profit sector, as well as concerns about the viability of these organizations. Of particular consideration is the funding of these organizations: will they have the resources to meet their present needs, and will they be able to manage ever-larger responsibilities, clients, and societal expectations? To explore the issues surrounding non-profits and gambling, the Non-Profit Gaming Study began in November 1998, as one part of the larger Canada West Foundation Gambling in Canada Project.
Estimator vrednosti ugla snage sinhronog generatora
Creators: name: Stojić, Đorđe
name: Veinović, Slavko
name: Joksimović, Dušan
name: Dragosavac, Jasna
name: Janda, Žarko
name: Đorđević, Milan
Publisher: name: Zenodo
Year: 2023

description: Estimacija trenutne vrednosti ugla snage predstavlja deo implementiran u okviru limitera ugla snage automatskog regulatora napona (ARN) sinhronog generator (SG). Estimator ugla snage moguće je realizovati bilo kao autonomnu jedinicu, bilo kao softverski modul implementiran u okviru ARN uređaja. 
Predloženo tehničko rešenje sadrži implementaciju estimatora ugla snage u formi autonomne hardversko/softverske jedinice. Problemi koje je neophodno rešiti tehničkim rešenjem obuhvataju: (i) realizacije modula za galvansku izolaciju i uobličavanje mernih signala, (ii) realizacija modula za generisanje izlaznih miliamperskih signala proporcionalnih estimiranoj vrednosti ugla snage, (iii) realizacija merno-komunikacionog hardvera baziranog na mikroprocesorskoj tehnologiji, (iv) realizacija softverskog modula za estimaciju trenutne vrednosti ugla snage SG na osnovu izmerenih vrednosti statorskih napona i statorskih struja.
การเปรียบเทียบประสิทธิภาพของสารสกัดหยาบจากพืชสมุนไพรด้วยเอทานอลในการไล่แมลงวันหัวเขียวในกระบวนการตากปลาสลิดแดดเดียว
Creators: name: อิสสริยา เอี่ยมสุวรรณ
Publisher: name: University of Phayao
Year: 2021
Subjects: ปลาสลิดแดดเดียว
สารสกัดสมุนไพรไทย
ผลิตภัณฑ์ไล่แมลงวัน

description: Naresuan Phayao Journal, 14, 2, 83-92
On existence of invariant Einstein metrics on a compact homogeneous space
Creators: name: Graev, Michail M.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 53C30

description: We prove that the existence of a positively defined, invariant Einstein metric $m$ on a connected homogeneous space $G/H$ of a compact Lie group $G$ is the consequence of non-contractibility of some compact set $C=X_{G,H}^Σ$ (Böhm polyhedron) introduced by C.Böhm. There is a natural continuous map of $C$ onto the flag complex $K_B$ of a finite graph $B$. The special case of $C = K_B$, $K_B$ non-contractible, is one of Böhm existence criteria, and the case of the graph $B$ non-connected is a improved version of the Graph Theorem (C.Böhm, M.Wang, and W.Ziller) actual for any $\mathfrak {z(g)}$. Moreover, preparation theorems of C. Böhm on retractions are revisited and new constructions of some topologic spaces are suggested.
description: 37 pages, 3 figures
title: Toxoplasma gondii
title: preventive and therapeutic effects of morphine and evaluation of treatment parameters of tachyzoites and infected macrophages in vitro and in a murine model
titleType: AlternativeTitle
Creators: name: Zaki, Leila
name: Ghaffarifar, Fatemeh
name: Sharifi, Zohreh
name: Horton, John
name: Sadraei, Javid
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2020
Subjects: subject: Toxoplasma gondii
subject: Morphine
subject: In vivo
subject: BALB/c mice
subject: 610

description: Common medicines for the treatment of toxoplasmosis have limited efficacy and unwanted side effects. Opiates can effect both innate and cell-mediated immunity and stimulate the immune responses in different parasitic infections. In this work, preventive and therapeutic effects of morphine were evaluated on the tachyzoites of Toxoplasma gondii and infected macrophages in vitro and in a murine model. Different concentrations of morphine (0.1 and 0.01 μg/ml) were evaluated on mortality rate of T. gondii by direct counting after 3 and 24 hours. The cytotoxic and apoptotic effects of these drugs were measured by the MTT assays and flow cytometry analysis, respectively. The same procedures were assessed in T. gondii-infected macrophages. The parasite loads were determined using quantitative polymerase chain reaction (qPCR). For in vivo assessment, BALB/c mice treated with morphine before or after infection with tachyzoites. The survival rate of animals, parasite load in the spleen, and the IFN-γ and IL-4 cytokines levels were measured. Morphine was effective on tachyzoites of T. gondii and had a reverse relationship with its concentration. The results of flow cytometry showed that the toxic effects of morphine on tachyzoites after 3 hours was not statistically significant (p<0.05). Also, apoptosis in infected MQs rose with a decreasing concentration of morphine. The parasitic load in MQs treated with morphine before infection was lower than that in cells treated after infection and the differences were statistically significant (p<0.01). In mice that received morphine before infection, survival rate, parasite load and the IFN-γ level were significantly lower than in mice treated after infection (p<0.01). The results of this study have shown that morphine in the pre-treatment group had higher anti-Toxoplasma activity than morphine in post-treatment in vitro and in murine model.
description: EXCLI Journal;Vol. 19 2020
ผลของ Spirulina (Arthrospira platensis) ต่อการรอดตายและการเจริญเติบโตของกบนา (Hoplobatrachus rugulosus)
Creators: name: สุธี วงศ์มณีประทีป
Publisher: name: University of Phayao
Year: 2021
Subjects: กบนา
สไปรูลินา
การรอดตาย
การเจริญเติบโต
ค่าโลหิตวิทยา

description: Naresuan Phayao Journal, 14, 2, 93-104
Intrinsic Alignment as an RSD Contaminant in the DESI Survey
Creators: name: Lamman, Claire
name: Eisenstein, Daniel
name: Aguilar, Jessica Nicole
name: Brooks, David
name: de la Macorra, Axel
name: Doel, Peter
name: Font-Ribera, Andreu
name: Gontcho, Satya Gontcho A
name: Honscheid, Klaus
name: Kehoe, Robert
name: Kisner, Theodore
name: Kremin, Anthony
name: Landriau, Martin
name: Levi, Michael
name: Miquel, Ramon
name: Moustakas, John
name: Palanque-Delabrouille, Nathalie
name: Poppett, Claire
name: Schubnell, Michael
name: Tarlé, Gregory
Publisher: name: arXiv
Year: 2022
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We measure the tidal alignment of the major axes of Luminous Red Galaxies (LRGs) from the Legacy Imaging Survey and use it to infer the artificial redshift-space distortion signature that will arise from an orientation-dependent, surface-brightness selection in the Dark Energy Spectroscopic Instrument (DESI) survey. Using photometric redshifts to down-weight the shape-density correlations due to weak lensing, we measure the intrinsic tidal alignment of LRGs. Separately, we estimate the net polarization of LRG orientations from DESI's fiber-magnitude target selection to be of order 10^-2 along the line of sight. Using these measurements and a linear tidal model, we forecast a 0.5% fractional decrease on the quadrupole of the 2-point correlation function for projected separations of 40-80 Mpc/h. We also use a halo catalog from the Abacus Summit cosmological simulation suite to reproduce this false quadrupole.
description: 13 pages, 13 figures. Submitted to MNRAS. For an accessible summary of this paper, see https://cmlamman.github.io/doc/fakeRSD_summary.pdf
สภาวะการสกัดที่เหมาะสมและการทำแห้งสารสกัดเมล็ดลิ้นจี่
Creators: name: ยุพารัตน์ โพธิเศษ
Publisher: name: University of Phayao
Year: 2021
Subjects: เมล็ดลิ้นจี่
การสกัด
ปริมาณสารต้านอนุมูลอิสระ
การทำแห้งโดยใช้ไมโครเวฟ

description: Naresuan Phayao Journal, 14, 2, 105-115
Sulfuric acid as a cryofluid and oxygen isotope reservoir of planetesimals
Creators: name: Hashimoto, Akihiko
name: Nakano, Yuki
Publisher: name: arXiv
Year: 2022
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The Sun exhibits a depletion in $^{17,18}$O relative to $^{16}$O by 6 % compared to the Earth and Moon$^{1}$. The origin of such a non-mass-dependent isotope fractionation has been extensively debated since the three-isotope-analysis$^{2}$ became available in 1970's. Self-shielding$^{3,4}$ of CO molecules against UV photons in the solar system's parent molecular cloud has been suggested as a source of the non-mass-dependent effect, in which a $^{17,18}$O-enriched oxygen was trapped by ice and selectively incorporated as water into planet-forming materials$^{5}$. The truth is that the Earth-Moon and other planetary objects deviate positively from the Sun by ~6 % in their isotopic compositions. A stunning exception is the magnetite/sulfide symplectite found in Acfer 094 meteorite, which shows 24 % enrichment in $^{17,18}$O relative to the Sun$^{6}$. Water does not explain the enrichment this high. Here we show that the SO and SO$_2$ molecules in the molecular cloud, ~106 % enriched in $^{17,18}$O relative to the Sun, evolved through the protoplanetary disk and planetesimal stages to become a sulfuric acid, 24 % enriched in $^{17,18}$O. The sulfuric acid provided a cryofluid environment in the planetesimal and by itself reacted with ferric iron to form an amorphous ferric-hydroxysulfate-hydrate, which eventually decomposed into the symplectite by shock. We indicate that the Acfer-094 symplectite and its progenitor, sulfuric acid, is strongly coupled with the material evolution in the solar system since the days of our molecular cloud.
description: 19 pages, 3 figures
Rolling the dice : Alberta's experience with direct democracy and video lottery terminals
Creators: name: Azmier, Jason J.
name: Jepson, Val
name: Pickup, Mark
Publisher: name: Canada West Foundation
Year: 1998
Subjects: subject: Video lottery terminals -- Alberta
subject: Gambling -- Alberta
subject: Gambling Literature

description: This report examines the key issues and events of the VLT debate and, more importantly, the groundbreaking grassroots campaign that took place in Calgary. Specifically, the report will address: (1) the history of the VLT debate in Alberta; (2) petitions and votes in Alberta; (3) Calgary’s petition campaign; and (4) who and what influenced the outcome.
Phase Space Reconstruction from Accelerator Beam Measurements Using Neural Networks and Differentiable Simulations
Creators: name: Roussel, Ryan
name: Edelen, Auralee
name: Mayes, Christopher
name: Ratner, Daniel
name: Gonzalez-Aguilera, Juan Pablo
name: Kim, Seongyeol
name: Wisniewski, Eric
name: Power, John
Publisher: name: arXiv
Year: 2022
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: Characterizing the phase space distribution of particle beams in accelerators is a central part of accelerator understanding and performance optimization. However, conventional reconstruction-based techniques either use simplifying assumptions or require specialized diagnostics to infer high-dimensional ($>$ 2D) beam properties. In this Letter, we introduce a general-purpose algorithm that combines neural networks with differentiable particle tracking to efficiently reconstruct high-dimensional phase space distributions without using specialized beam diagnostics or beam manipulations. We demonstrate that our algorithm accurately reconstructs detailed 4D phase space distributions with corresponding confidence intervals in both simulation and experiment using a single focusing quadrupole and diagnostic screen. This technique allows for the measurement of multiple correlated phase spaces simultaneously, which will enable simplified 6D phase space distribution reconstructions in the future.
Nonlinearly constrained optimization via sequential regularized linear programming
Creators: name: Crowe, Mitch
Publisher: name: University of British Columbia
Year: 2010

description: This thesis proposes a new active-set method for large-scale nonlinearly con strained optimization. The method solves a sequence of linear programs to generate search directions. The typical approach for globalization is based on damping the search directions with a trust-region constraint; our proposed ap proach is instead based on using a 2-norm regularization term in the objective. Numerical evidence is presented which demonstrates scaling inefficiencies in current sequential linear programming algorithms that use a trust-region constraint. Specifically, we show that the trust-region constraints in the trustregion subproblems significantly reduce the warm-start efficiency of these subproblem solves, and also unnecessarily induce infeasible subproblems. We also show that the use of a regularized linear programming (RLP) step largely elim inates these inefficiencies and, additionally, that the dual problem to RLP is a bound-constrained least-squares problem, which may allow for very efficient subproblem solves using gradient-projection-type algorithms. Two new algorithms were implemented and are presented in this thesis, based on solving sequences of RLPs and trust-region constrained LPs. These algorithms are used to demonstrate the effectiveness of each type of subproblem, which we extrapolate onto the effectiveness of an RLP-based algorithm with the addition of Newton-like steps. All of the source code needed to reproduce the figures and tables presented in this thesis is available online at http: //www.cs.ubc.ca/labs/scl/thesis/lOcrowe/
The therapeutic potential of losartan in lung metastasis of colorectal cancer
Creators: name: Hashemzehi, Milad
name: Naghibzadeh, Niloufar
name: Asgharzadeh, Fereshteh
name: Mostafapour, Asma
name: Hassanian, Seyed Mahdi
name: Ferns, Gordon A.
name: Cho, William C.
name: Avan, Amir
name: Khazaei, Majid
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2020
Subjects: subject: Renin-angiotensin system
subject: Losartan
subject: Colorectal cancer
subject: Lung metastasis
subject: 610

description: Colorectal cancer (CRC) is a common cancer with a high incidence rate. Components of the renin-angiotensin system (RAS) have been reported to be dysregulated in several malignancies including CRC. Here, we have explored the potential anti-metastatic effects of a RAS inhibitor, losartan, in an experimental model of lung metastasis in CRC. A murine model of lung metastasis of CRC was used, which involved the intravenous injection of CT26 cells via a tail vein. Four experimental groups comprised: an untreated group; a group that received 5-FU which was administered intraperitoneally; a losartan group that received a combination group that received 5-FU plus losartan . We evaluated the anti-inflammatory effects of losartan by histopathological method, and the measurement of oxidative or antioxidant markers including malondialdehyde (MDA) and total-thiols (T-SH) tissue levels, superoxide-dismutase (SOD) and catalase activity. We found that losartan inhibited lung metastasis of CRC and there was a reduction of the IL-6 expression level in the tissue sample. It was also associated with reduced levels of the anti-angiogenic factor Vascular endothelial growth factor (VEGF). Furthermore, we found that losartan induced oxidative stress as assessed by an elevation of MDA level, reduction of T-SH, SOD and catalase activities in lung tissue. Our findings demonstrated that losartan ameliorates angiogenesis, inflammation and the induction of oxidative stress via Angiotensin II type I receptor (AT1R). This may shine some lights on targeting the RAS pathway as a potential therapeutic approach in the treatment of metastatic CRC patients.
description: EXCLI Journal;Vol. 19 2020
Hot exozodiacal dust resolved around Vega with IOTA/IONIC
Creators: name: Defrère, D.
name: Absil, O.
name: Augereau, J. -C.
name: di Folco, E.
name: Berger, J. -P.
name: Foresto, V. Coudé du
name: Kervella, P.
name: Bouquin, J. -B. Le
name: Lebreton, J.
name: Millan-Gabet, R.
name: Monnier, J. D.
name: Olofsson, J.
name: Traub, W.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Although debris discs have been detected around a significant number of main-sequence stars, only a few of them are known to harbour hot dust in their inner part where terrestrial planets may have formed. Thanks to infrared interferometric observations, it is possible to obtain a direct measurement of these regions, which are of prime importance for preparing future exo-Earth characterisation missions. In this context, we have resolved the exozodiacal dust disc around Vega with the help of infrared stellar interferometry and estimated the integrated H-band flux originating from the first few AUs of the debris disc. Using precise H-band interferometric measurements obtained with the 3-telescope IOTA/IONIC interferometer (Mount Hopkins, Arizona), thorough modelling of both interferometric data (squared visibility and closure phase) and spectral energy distribution was performed to constrain the nature of the near-infrared excess emission. The most straightforward scenario consists in a compact dust disc producing a thermal emission that is largely dominated by small grains located between 0.1 and 0.3 AU from Vega and accounting for 1.23 +/- 0.45% of the near-infrared stellar flux for our best-fit model. This flux ratio is shown to vary slightly with the geometry of the model used to fit our interferometric data (variations within +/-0.19%). Initially revealed by K-band CHARA/FLUOR observations, the presence of hot exozodiacal dust in the vicinity of Vega is confirmed by our H-band IOTA/IONIC measurements at the 3-sigma level. Whereas the origin of the dust is still uncertain, its presence and the possible connection with the outer disc suggest that the Vega system is currently undergoing major dynamical perturbations.
description: 10 pages, 9 figures, accepted for publication in A&A
PyPSA-Earth. A New Global Open Energy System Optimization Model Demonstrated in Africa
Creators: name: Parzen, Maximilian
name: Abdel-Khalek, Hazem
name: Fedorova, Ekaterina
name: Mahmood, Matin
name: Frysztacki, Martha Maria
name: Hampp, Johannes
name: Franken, Lukas
name: Schumm, Leon
name: Neumann, Fabian
name: Poli, Davide
name: Kiprakis, Aristides
name: Fioriti, Davide
Publisher: name: arXiv
Year: 2022
Subjects: subject: Physics and Society (physics.soc-ph)
subject: FOS: Physical sciences

description: Macro-energy system modelling is used by decision-makers to steer the global energy transition toward an affordable, sustainable and reliable future. Closed-source models are the current standard for most policy and industry decisions. However, open models have proven to be competitive alternatives that promote science, robust technical analysis, collaboration and transparent policy decision-making. Yet, two issues slow the adoption: open models are often designed with limited geographic scope, hindering synergies from collaboration, or are based on low spatially resolved data, limiting their use. Here we introduce PyPSA-Earth, the first open-source global energy system model with data in high spatial and temporal resolution. It enables large-scale collaboration by providing a tool that can model the world energy system or any subset of it. This work is derived from the European PyPSA-Eur model using new data and functions. It is suitable for operational as well as combined generation, storage and transmission expansion studies. The model provides two main features: (1) customizable data extraction and preparation scripts with global coverage and (2) a PyPSA energy modelling framework integration. The data includes electricity demand, generation and medium to high-voltage networks from open sources, yet additional data can be further integrated. A broad range of clustering and grid meshing strategies help adapt the model to computational and practical needs. A data validation for the entire African continent is performed and the optimization features are tested with a 2060 net-zero planning study for Nigeria. The demonstration shows that the presented developments can build a highly detailed energy system model for energy planning studies to support policy and technical decision-making. We welcome joining forces to address the challenges of the energy transition together.
description: 36 pages, 14 figures, 3 tables
Induction and repression effects on CYP and transporter protein abundance by azole mixture uptake in rat liver
Creators: name: Hammer, Helen
name: Schmidt, Flavia
name: Heise, Tanja
name: Knebel, Constanze
name: Dabrowski, Alexander
name: Planatscher, Hannes
name: Kneuer, Carsten
name: Marx-Stoelting, Philip
name: Pötz, Oliver
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2020
Subjects: subject: ABC transporter
subject: Azole fungicides
subject: Cytochrome P450
subject: Immunoaffinity-based mass spectrometry
subject: Liver toxicity
subject: Pesticides
subject: Pesticide mixtures
subject: SLC transporter
subject: 610

description: Detection of mixture effects is a major challenge in current experimental and regulatory toxicology. Robust markers are needed that are easy to quantify and responsive to chemical stressors in a broad dose range. Several hepatic enzymes and proteins related to drug metabolism like cytochrome-P-450 (CYP) enzymes and transporters have been shown to be responsive to pesticide active substances in a broad dose range and are therefore good candidates to be used as markers for mixture toxicity. Even though they can be well quantified at the mRNA level, quantification on the protein level is challenging because most of these proteins are membrane bound. Here we report the development of mass spectrometry-based assays using triple-x-proteomics (TXP) antibodies in combination with targeted selected ion monitoring (tSIM) to quantify changes of protein levels due to exposure to mixtures of pesticide active substances. Our results indicate that changes on the protein level of CYP1A1, ABCB2, ABCC3 are in line with observations on the mRNA and enzyme activity level and are indicative of mixture effects. Therefore, the tests are promising to reveal effects by chemical mixture effects in toxicological studies in rats.
description: EXCLI Journal;Vol. 19 2020
Quantum vacuum and dark matter
Creators: name: Hajdukovic, Dragan Slavkov
Publisher: name: arXiv
Year: 2011
Subjects: subject: General Physics (physics.gen-ph)
subject: FOS: Physical sciences

description: Recently, the gravitational polarization of the quantum vacuum was proposed as alternative to the dark matter paradigm. In the present paper we consider four benchmark measurements: the universality of the central surface density of galaxy dark matter haloes, the cored dark matter haloes in dwarf spheroidal galaxies, the non-existence of dark disks in spiral galaxies and distribution of dark matter after collision of clusters of galaxies (the Bullet cluster is a famous example). Only some of these phenomena (but not all of them) can (in principle) be explained by the dark matter and the theories of modified gravity. However, we argue that the framework of the gravitational polarization of the quantum vacuum allows the understanding of the totality of these phenomena.
description: Accepted for publication in Astrophysics and Space Science
Non-profits and gambling expansion : the British Columbia experience
Creators: name: Campbell, Colin S. (Colin Samuel), 1948-
Publisher: name: Canada West Foundation
Year: 2000
Subjects: subject: Nonprofit corporations -- British Columbia -- Finance
subject: Gambling -- Social aspects -- British Columbia
subject: Charities -- British Columbia -- Finance
subject: Gambling Literature

description: The purpose of this study is to examine the historical influence of charitable and non-profit organizations in bringing about changes to the federal laws and provincial policies that have regulated gambling. The primary research questions that this study addresses include the following: Is there a discernable pattern in the perspectives held by non-profit organizations with respect to gambling policies and issues? Have some types of non-profit organizations been more active in lobbying federal or provincial governments for special considerations in charity gambling policy decisions? What preferences for particular forms of gambling (bingo, raffles, charity casinos) have non-profit organizations demonstrated? To what extent, if any, have provincial governments and Crown corporations justified gambling expansion as serving the interests of non-profit organizations? What relationships have emerged between regulators and the regulated (i.e., between provincial gaming regulatory authorities and non-profit/charitable organizations)? How have these relationships evolved? To what extent have non-profit organizations opposed gambling expansion, and for what reasons?
Evolution of charm-meson ratios in an expanding hadron gas
Creators: name: Braaten, Eric
name: Bruschini, Roberto
name: He, Li-Ping
name: Ingles, Kevin
name: Jiang, Jun
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the time evolution of the numbers of charm mesons after the kinetic freeze-out of the hadron gas produced by a central heavy-ion collision. The $πD^\ast \to πD^\ast$ reaction rates have $t$-channel singularities that give contributions inversely proportional to the thermal width of the $D$. The ratio of the $D^0$ and $D^+$ production rates can differ significantly from those predicted using the measured $D^\ast$ branching fractions.
description: 7 pages, 1 figure
A note on stability of the vertical uniform rotations of the heavy top
Creators: name: Comanescu, Dan
Publisher: name: arXiv
Year: 2012
Subjects: subject: Mathematical Physics (math-ph)
subject: Dynamical Systems (math.DS)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 34D20, 37B25, 70E50, 70H14

description: We prove that the stability problem of a vertical uniform rotation of a heavy top is completely solved by using the linearization method and the conserved quantities of the differential system which describe the rotation of the heavy top.
A multi-fragment real-time extension of projected density matrix embedding theory: Non-equilibrium electron dynamics in extended systems
Creators: name: Yehorova, Dariia
name: Kretchmer, Joshua S.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: In this work, we derive a multi-fragment real-time extension of projected density matrix embedding theory (pDMET) designed to treat non-equilibrium electron dynamics in strongly correlated systems. As in the previously developed static pDMET, real-time pDMET partitions the total system into many fragments; the coupling between each fragment and the rest of the system is treated through a compact representation of the environment in terms of a quantum bath. Real-time pDMET involves simultaneously propagating the wavefunctions for each separate fragment-bath embedding system along with an auxiliary mean-field wavefunction of the total system. The equations of motion are derived by (i) projecting the time-dependent Schrodinger equation in the fragment and bath space associated with each separate fragment and by (ii) enforcing the pDMET matching conditions between the global 1-particle reduced density matrix (1-RDM) obtained from the fragment calculations and the mean-field 1-RDM at all points in time. The accuracy of the method is benchmarked through comparisons to the time-dependent density-matrix renormalization group (TD-DMRG) and time-dependent Hartree-Fock (TDHF) theory; the methods were applied to a single-impurity Anderson model and multi-impurity Anderson models with ordered and disordered distributions of the impurities. The results demonstrate a large improvement over TDHF and rapid convergence to the exact dynamics with an increase in fragment size. Our results demonstrate that real-time pDMET is a promising and flexible method to simulate non-equilibrium electron dynamics in heterogeneous systems of large size.
Gambling, alcohol & other drugs : prevalence & implications of dual problem clients
Creators: name: Kaplan, Gerry S.
name: Addictions Foundation Of Manitoba
name: Davis, Bob
Publisher: name: Addictions Foundation of Manitoba
Year: 1997
Subjects: subject: Gambling -- Manitoba
subject: Alcoholism -- Manitoba
subject: Substance abuse -- Manitoba
subject: Gambling Literature

description: This study examined three groups of Addictions Foundation of Manitoba (AFM)clients: those with only gambling problems, those with only chemical problems and those experiencing both types of problems. The study's overall goal was to explore the degree to which the types of problems clients experience correlate with selected demographic characteristics and social indicators.
title: Treating Bladder Cancer: Engineering of Current and Next Generation Antibody-, Fusion Protein-, mRNA-, Cell- and Viral-Based Therapeutics
Creators: name: Bogen, Jan Patrick
name: Grzeschik, Julius
name: Jakobsen, Jørn
name: Bähre, Alexandra
name: Hock, Björn
name: Kolmar, Harald
Publisher: name: Frontiers
Year: 2021

description: Bladder cancer is a frequent malignancy and has a clinical need for new therapeutic approaches. Antibody and protein technologies came a long way in recent years and new engineering approaches were applied to generate innovative therapeutic entities with novel mechanisms of action. Furthermore, mRNA-based pharmaceuticals recently reached the market and CAR-T cells and viral-based gene therapy remain a major focus of biomedical research. This review focuses on the engineering of biologics, particularly therapeutic antibodies and their application in preclinical development and clinical trials, as well as approved monoclonal antibodies for the treatment of bladder cancer. Besides, newly emerging entities in the realm of bladder cancer like mRNA, gene therapy or cell-based therapeutics are discussed and evaluated. As many discussed molecules exhibit unique mechanisms of action based on innovative protein engineering, they reflect the next generation of cancer drugs. This review will shed light on the engineering strategies applied to develop these next generation treatments and provides deeper insights into their preclinical profiles, clinical stages, and ongoing trials. Furthermore, the distribution and expression of the targeted antigens and the intended mechanisms of action are elucidated.
Study of chiral and deconfinement transition in lattice QCD with improved staggered actions
Creators: name: Bazavov, A.
name: Petreczky, P.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present results on the chiral and deconfinement properties of the QCD transition at finite temperature. We performed calculations using asqtad and HISQ/tree actions using lattices with temporal extent N_tau=6, 8 and 12 allowing to control the approach to the continuum limit. We analyze the chiral transition in terms of universal O(N) scaling functions. From peaks in the scaling functions we perform a simultaneous continuum extrapolation for HISQ/tree and asqtad to derive the critical temperature, T_c= 157 +/- 6 MeV.
description: Latex, 4 pages, contribution to the proceedings of Quark Matter 2011
Dynamical Mean-Field Theory
Creators: name: Vollhardt, D.
name: Byczuk, K.
name: Kollar, M.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The dynamical mean-field theory (DMFT) is a widely applicable approximation scheme for the investigation of correlated quantum many-particle systems on a lattice, e.g., electrons in solids and cold atoms in optical lattices. In particular, the combination of the DMFT with conventional methods for the calculation of electronic band structures has led to a powerful numerical approach which allows one to explore the properties of correlated materials. In this introductory article we discuss the foundations of the DMFT, derive the underlying self-consistency equations, and present several applications which have provided important insights into the properties of correlated matter.
description: Chapter in "Theoretical Methods for Strongly Correlated Systems", edited by A. Avella and F. Mancini, Springer (2011), 31 pages, 5 figures
Exechia fusca
Creators: name: El Mouden, Mohamed Amin
name: Chandler, Peter J.
name: Saidoun, Imane
name: Driauach, Ouafaa
name: Belqat, Boutaïna
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Mycetophilidae
Exechia
Exechia fusca

description: Exechia fusca (Meigen, 1804)
Material examined.
Morocco – Middle Atlas Region • 257 ♂♂; Gouffre Izora; 19/V/2022; K. Aattouch, M. El Ouahabi and M. A. El Mouden leg; UAE-FST MA 22/24111 • 119 ♂♂; Grotte Bouslama; 19/V/2022; K. Aattouch, M. El Ouahabi and M. A. El Mouden leg; UAE-FST MA 22/24112 • 3 ♂♂; Grotte Bouhayati; 20/V/2022; K. Aattouch, M. El Ouahabi and M. A. El Mouden leg; UAE-FST MA 22/24113 • 2 ♂♂; Aïn Admam; 22/V/2022; K. Aattouch, M. El Ouahabi and M. A. El Mouden leg; UAE-FST MA 22/24114.
North African distribution.
Algeria (Chandler and Ribeiro 1995); Tunisia (Chandler 1994; Chandler and Ribeiro 1995); Morocco (Banamar et al. 2020).
description: Published as part of El Mouden, Mohamed Amin, Chandler, Peter J., Saidoun, Imane, Driauach, Ouafaa & Belqat, Boutaïna, 2025, A new species of Docosia Winnertz, 1864 and new records of fungus gnats (Diptera, Bolitophilidae, Keroplatidae and Mycetophilidae) from North Africa, pp. 349-379 in ZooKeys 1233 on pages 349-379, DOI: 10.3897/zookeys.1233.130502
Magnetic Fields In Pms Stars: Harps Spectropolarimetry Of Sharp-Lined Herbig Ae Stars
Creators: name: Järvinen, Silva P.
name: Carroll, Thorsten A.
name: Hubrig, Swetlana
name: Schöller, Markus
name: Ilyin, Ilya
name: Korhonen, Heidi H.
Publisher: name: Zenodo
Year: 2016
Subjects: cool
stars

description: Herbig Ae/Be-type stars are analogs of T Tauri stars in the higher mass

range. Spectropolarimetric studies involving sharp-lined Herbig Ae stars

appear to be a promising approach for the detection of their magnetic fields.

We report the results of our HARPS high-resolution spectropolarimetric

analysis of four Herbig Ae stars with low v sin i values: HD 101412,

HD 104237, HD 190073, and PDS 2. The role of contamination by the surrounding

warm  circumstellar matter for the appearance of Zeeman features is discussed

for the first time.
description: Poster #312
description: {"references": ["Hubrig, S., Carroll, T.A., Sch\u00f6ller, M., Ilyin, I. 2015, MNRAS, 449, L118", "Ja\u0308rvinen, S.P., Carroll, T.A., Hubrig, S., et al. 2015, A&A, 584, A15", "Ja\u0308rvinen, S.P., Hubrig, S., Sch\u00f6ller, M., et al. 2016, AN, 337, 329"]}