cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Observational Constraints on Extended Starobinsky and Weyl Gravity Model of Inflation
Creators: name: Burikham, Piyabut
name: Chantavat, Teeraparb
name: Boonaom, Pongsapat
Publisher: name: arXiv
Year: 2023
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present constraints on the extended Starobinsky and Weyl gravity model of inflation using updated available observational data. The data includes cosmic microwave background (CMB) anisotropy measurements from Planck and BICEP/Keck 2018 (BK18), as well as large-scale structure data encompassing cosmic shear and galaxy autocorrelation and cross-correlation functions measurements from Dark Energy Survey (DES), baryonic acoustic oscillation (BAO) measurements from 6dF, MGS and BOSS, and distance measurements from supernovae type Ia from Pantheon+ samples. By introducing a single additional parameter, each model extends the Starobinsky model to encompass larger region of parameter space while remaining consistent with all observational data. Our findings demonstrate that the inclusion of higher-order terms loosen the constraint on the upper bound of $e$-folding number $N_{\rm e}$ due to the presence of small additional parameter. The maximum limit on $N_{\rm e}$ could be refined by considering the reheating process to $N_{\rm e}<55-59$ for $k_{*}=0.002, 0.05$ Mpc$^{-1}$. These models extend viable range of tensor-to-scalar ratio~($r$) to very small value $r<0.002$ in contrast to the original $R^2$ Starobinsky model. In addition, our results continue to emphasize the tension in $H_0$ and $S_8$ between early-time CMB measurements and late-time large-scale structure observations.
description: 13 figures, 11 tables, matched the published version
Retrotransposon targeting to RNA polymerase III-transcribed genes
Creators: name: Cheung, Stephanie
name: Manhas, Savrina
name: Measday, Vivien
Publisher: name: BioMed Central
Year: 2018

description: Retrotransposons are genetic elements that are similar in structure and life cycle to retroviruses by replicating via an RNA intermediate and inserting into a host genome. The Saccharomyces cerevisiae (S. cerevisiae) Ty1–5 elements are long terminal repeat (LTR) retrotransposons that are members of the Ty1-copia (Pseudoviridae) or Ty3-gypsy (Metaviridae) families. Four of the five S. cerevisiae Ty elements are inserted into the genome upstream of RNA Polymerase (Pol) III-transcribed genes such as transfer RNA (tRNA) genes. This particular genomic locus provides a safe environment for Ty element insertion without disruption of the host genome and is a targeting strategy used by retrotransposons that insert into compact genomes of hosts such as S. cerevisiae and the social amoeba Dictyostelium. The mechanism by which Ty1 targeting is achieved has been recently solved due to the discovery of an interaction between Ty1 Integrase (IN) and RNA Pol III subunits. We describe the methods used to identify the Ty1-IN interaction with Pol III and the Ty1 targeting consequences if the interaction is perturbed. The details of Ty1 targeting are just beginning to emerge and many unexplored areas remain including consideration of the 3-dimensional shape of genome. We present a variety of other retrotransposon families that insert adjacent to Pol III-transcribed genes and the mechanism by which the host machinery has been hijacked to accomplish this targeting strategy. Finally, we discuss why retrotransposons selected Pol III-transcribed genes as a target during evolution and how retrotransposons have shaped genome architecture.
Supplementary document for Picosecond pulses from a mid-infrared interband cascade laser - 4118836.pdf
Creators: name: Hillbrand, Johannes
name: Beiser, Maximilian
name: Andrews, Aaron
name: Detz, Hermann
name: Weih, Robert
name: Schade, Anne
name: Höfling, Sven
name: Strasser, Gottfried
name: Schwarz, Benedikt
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Lasers and Quantum Electronics

description: Supplemental document in answer to the reviewer comments
Konzeptionelles hydro(geo)logisches Modell zur Bewertung von Maßnahmen zur Reduktion der Grundwasserbelastung durch Nitrat
Creators: name: Kuhr, Petra
Publisher: name: Bundesanstalt für Gewässerkunde, Koblenz
Year: 2012
Subjects: subject: Water resources research

description: Hydrologie und Wasserbewirtschaftung / BfG – Jahrgang: 56.2012,3 - ISSN 1439-1783
Non-monotonic concurrent constraint program verification using phase semantics.
Creators: name: Yilma, Yirgu.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2000
Subjects: subject: Computer Science.

description: We present two kinds of Concurrent Constraint Programming languages. The first one is based on a classical logic framework, whereas the second one is based on linear logic. The latter will be at the center of our present discussion since it provides several features such as ability to consume constraints and a full translation of the language into the underlying logic. The provability semantics of this logic can then be used to test programs for safety properties. We will also investigate ways of automating this verification technique, notably by means of finite models of the logic.
On The Structure of Plasma Jets in the Rotating Plasma Experiment
Creators: name: Valenzuela-Villaseca, V.
name: Suttle, L. G.
name: Suzuki-Vidal, F.
name: Halliday, J. W. D.
name: Russell, D. R.
name: Merlini, S.
name: Tubman, E. R.
name: Hare, J. D.
name: Chittenden, J. P.
name: Koepke, M. E.
name: Blackman, E. G.
name: Lebedev, S. V.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: Recent pulsed-power experiments have demonstrated the formation of astrophysically-relevant, differentially rotating plasmas [1]. Key features of the plasma flows are the discovery of a quasi-Keplerian rotation curve, the launching of highly-collimated angular-momentum-transporting axial jets, and a hollow density structure sustained by the centrifugal barrier effect. In this communication we discuss several features of the plasma structure in these experiments through order-of-magnitude models. First, we show that the observed rotation velocity would produce a centrifugal force strong enough to support the hollow density profile. Second, we show that the axial jet should diverge much faster than what was observed, were it not for a magnetized halo with 3T which surrounds the jet and exerts pressure on the interface.Finally, we discuss the temperature structure in the axial jet and plasma halo.We show that a 3T magnetic field would also suppress electron heat conduction,leading to the flat profile observed experimentally. We also find that the axial jet is efficiently radiatively cooled,whereas the halo is not, which would explain the thermal decoupling between the two regions.
description: Second version with clarifications on text and figures, and explicit calculations regarding the omega-effect. Manuscript re-submitted to IEEE Transactions On Plasma Science. 4 Figures
Statistica generala cu aplicatii in contabilitate
Creators: name: Savoiu, Gheorghe
Publisher: name: Editura Universitara
Year: 2012
Subjects: subject: 3 Social sciences
subject: 311 Statistics as a science.Statistical theory

description: Aceasta carte adauga celor doua stiinte gemene cunoscute, statistica si demografia, o a treia, respectiv stiinta contabila, recunoscand astfel si traditiile si evolutia lor relativ comuna pentru cateva milenii de istorie. Contabilitatea a aparut corelata cu datele referitoare la proprietate si bunastare solicitate la recensamant. Marile civilizatii antice, babiloniana, chineza, egipteana, greaca si romana, au oferit astfel prin recensamant premisele aparitiei si dezvoltarii dintr-un arbore comun a celor trei stiinte gemene statistica, demografie si contabilitate, in forme discontinue, diverse, nereglementate riguros pana la romani, dar detinand un potential de exceptie.
		Please look on datacite.org to find the newest versions of sample data and schemas.
Genetic analysis and molecular characterization of the naturally-occurring penicillinase-producing plasmids in Neisseria gonorrhoeae.
Creators: name: Yeung, Kwok-Him.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1989
Subjects: subject: Biology, Molecular.

description: Two naturally-occurring beta-lactamase producing plasmids from Neisseria gonorrhoeae, 7.2 kilobases (kB) (Asian-type, pJD4) and 5.1 kb (African-type, pJD5) in size, were analysed and mapped by restriction endonuclease analysis and DNA-DNA heteroduplex analysis. The two plasmids were similar except for a 2.1 kb fragment missing in pJD5, as compared to pJD4, which was located 1.74 kb counter-clockwise from the unique PstI site. In addition, a novel penicillinase-producing plasmid, 4.9 kb (pJD7, 'Toronto-type') in size was discovered during the study and was compared to pJD4 and pJD5. Except for a 2.3 kb fragment, pJD7 was shown to be similar to pJD4 and probably derived from pJD4. Plasmid pJD7 was compared to a plasmid of reportedly smaller size, pGO4717, isolated in the Netherlands and was found to be identical to it. Part of the large BamHI fragment of pJD4 was sequenced and compared to that of Tn3. It was shown that after base 79 from the BamHI site, the sequence starts to differ. The presence of two replication regions on pJD4 has been identified. Through the construction of mini-plasmids (pJD8, pJD9), the replication region of pJD4 was located on a 1.5 kb fragment, designated region 'a', which included the unique HindIII site. However, fragment 'a' was absent in pJD5. A 1.5 kb fragment (region 'b') was found to be required for the replication of this plasmid. In pJD4, the nucleotide sequence of region 'b' was interrupted by region 'a'. Incompatibility studies showed that, in vitro derived deletion-derivatives from pJD4 and pJD5, containing either region 'a' or region 'b', were compatible. Sequence analysis of region 'a' indicated that this region shares many characteristics of plasmids such as pSC101, P1, F, and R6K. Ten conjugative plasmids were tested for their ability to mobilize plasmid pJD4 between E. coli strains. Plasmid pJD4 was mobilized by RP4 (IncP), R124 (IncIV), pBG791 (IncI$\alpha)$ and R100 (IncFII), but not by R621a (IncI$\gamma$), R199 (IncN), R6K (IncX), R1drd16 (IncFII), TP124 (IncH$\sp{\rm e}$) and S-a (IncW). The 2.4 kb BamHI fragment of pJD4, containing the beta-lactamase gene and a 1.0 kb BamHI- HinfI fragment designated region 'M', was cloned into pACYC184, and was shown to be required in cis for the mobilization of the recombinant plasmid by pBG791. The entire DNA sequence of region 'M' was analysed, and contained sequences that were found to be essential for the conjugal transfer of other plasmids. Mobilization of deletion derivatives of the 7.2 kb and the 5.1 kb penicillinase-producing plasmids of N. gonorrhoeae by pBG791 indicated another origin of transfer, located within one of the two replication regions in pJD4.
Characterization of the CD177 interaction with the ANCA antigen proteinase 3
Creators: name: Jerke, Uwe
name: Marino, Stephen F.
name: Daumke, Oliver
name: Kettritz, Ralph
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Kidney diseases
subject: Proteases
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Proteinase 3 is a serine protease found in neutrophil granules and on the extracellular neutrophil membrane (mPR3). mPR3 is a major antigen for anti- neutrophil cytoplasmic antibodies (PR3-ANCAs), autoantibodies causing fatal autoimmune diseases. In most individuals, a subpopulation of neutrophils also produce CD177, proposed to present additional PR3 on the surface, resulting in CD177neg/mPR3low and CD177pos/mPR3high neutrophil subsets. A positive correlation has been shown between mPR3 abundance, disease incidence, and clinical outcome. We present here a detailed investigation of the PR3:CD177 complex, verifying the interaction, demonstrating the effect of binding on PR3 proteolytic activity and explaining the accessibility of major PR3-ANCA epitopes. We observed high affinity PR3:CD177 complex formation by surface plasmon resonance. Using flow cytometry and a PR3-specific FRET assay, we found that CD177 binding reduced the proteolytic activity of PR3 in vitro using purified proteins, in neutrophil degranulation supernatants containing wtPR3 and directly on mPR3high neutrophils and PR3-loaded HEK cells. Finally, CD177pos/mPR3high neutrophils showed no migration advantage in vitro or in vivo when migrating from the blood into the oral cavity. We illuminate details of the PR3:CD177 interaction explaining mPR3 membrane orientation and proteolytic activity with relevance to ANCA activation of the distinct mPR3 neutrophil populations.
Supplementary document for Coupled ptychography and tomography algorithm improves reconstruction of experimental data - 4120720.pdf
Creators: name: Kahnt, Maik
name: Becher, Joahnnes
name: Brückner, Dennis
name: Fam, Yakub
name: Sheppard, Thomas
name: Weissenberger, Tobias
name: Wittwer, Felix
name: Grunwaldt, Jan-Dierk
name: Schwieger, Wilhelm
name: Schroer, Christian
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Optical Physics not elsewhere classified

description: Supplemental Document
Dynamics of spin-momentum entanglement from superradiant phase transitions
Creators: name: Chelpanova, Oksana
name: Seetharam, Kushal
name: Rosa-Medina, Rodrigo
name: Reiter, Nicola
name: Finger, Fabian
name: Donner, Tobias
name: Marino, Jamir
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Exploring operational regimes of many-body cavity QED with multi-level atoms remains an exciting research frontier for their enhanced storage capabilities of intra-level quantum correlations. In this work, we consider an experimentally feasible many-body cavity QED model describing a four-level system, where each of those levels is formed from a combination of different spin and momentum states of ultra-cold atoms in a cavity. The resulting model comprises a pair of Dicke Hamiltonians constructed from pseudo-spin operators, effectively capturing two intertwined superradiant phase transitions. The phase diagram reveals regions featuring weak and strong entangled states of spin and momentum atomic degrees of freedom. These states exhibit different dynamical responses, ranging from slow to fast relaxation, with the added option of persistent entanglement temporal oscillations. We discuss the role of cavity losses in steering the system's dynamics into such entangled states and propose a readout scheme that leverages different light polarizations within the cavity. Our work paves the way to connect the rich variety of non-equilibrium phase transitions that occur in many-body cavity QED to the buildup of quantum correlations in systems with multi-level atom descriptions.
description: 13+12 pages, 8+2 figures
The regulation of beta-adrenoceptors in two teleost fishes
Creators: name: Dugan, Stephen G
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Biology, Animal Physiology.

description: Exposure of an organism to a stressor results in a primary stress response. A part of this response involves the release of the catecholamines (CA), adrenaline (ADR) and noradrenaline (NADR), which exert their actions by binding to specific membrane binding sites or receptors termed adrenergic receptors or adrenoceptors (ARs). Continuous exposure to a hormone results in a decrease in the responsiveness of the cell. This process, termed desensitization may reduce the cell's responsiveness only to that hormone (homologous) or to another agonist (heterologous). Moreover, prolonged agonist exposure may result in the internalization (sequestration) and possible degradation of the receptor (down-regulation). These processes have been well studied for the three beta-AR subtypes in mammals, however little is known about how beta-ARs are regulated in teleost fish. The goal of this thesis was to examine the regulation of the beta-ARs in two species of teleosts, the rainbow trout (Oncorhynchus mykiss ) and the black bullhead (Ameiurus melas). Fish were exposed to various stressors including prolonged agonist exposure, physical exertion and hypercarbia and receptor binding characteristics [affinity (K d) and number of binding sites (Bmax)] as well as function were examined. Chasing to exhaustion and prolonged feeding of the beta-agonist clenbuterol significantly reduced the Bmax of hepatic beta 2-ARs in rainbow trout by 27% and 33%, respectively. In contrast, exposure to hypercarbia did not significantly affect rainbow trout gill beta-ARs. Pharmacological characterization of the gill beta-AR supports an atypical classification compared with the three classic mammalian subtypes. No significant differences were observed in binding parameters for bullhead hepatic beta-ARs after a 24 hour exposure to the beta-agonist isoproterenol or a 1 hour air-exposure. However, air-exposure did result in a moderate desensitization in CA-stimulated hepatic glucose production. Phylogenetic analysis groups the bullhead hepatic beta-AR with the mammalian beta3-ARs, which is not supported by the pharmacological classification of a beta2-AR subtype. This study was the first to comparatively examine 3-AR regulation for different subtypes of teleost beta-ARs. Findings suggest beta-ARs in teleosts possess different sensitivities to down-regulation and desensitization as is seen with the different mammalian beta-AR subtypes.
Integrating resiliency in intelligent decision support systems for real-time management of disruptions in large-scale supply chains
Creators: name: Mohammadi, Mahsa
Publisher: name: University of British Columbia
Year: 2025

description: In an era marked by rapid technological advancements, volatile market conditions, and global disruptions, effective Supply Chain (SC) management requires innovative approaches to address uncertainty, complexity, and dynamic changes. This dissertation presents the development and application of a set of novel Intelligent Decision Support Systems (IDSSs) for solving large-scale, stochastic, and dynamic SC networks under disruptions. The proposed IDSSs are validated using different case studies in diverse domains, including e-commerce, manufacturing, healthcare, and sustainability. Specifically, the research introduces four novel resilient IDSSs that integrate advanced optimization, machine learning, reinforcement learning, and logistics simulations to tackle some of the real-world challenges in the event of major disruptions in SCs. The first proposed resilient IDSS optimizes last-mile delivery in urban areas using mobile depots and crowd-shipping, achieving significant reductions in delivery time, cost, and environmental impact. The second IDSS enhances resilience in global SCs by developing a multi-stage stochastic dynamic programming to deal with disruptions and optimize logistics operations under uncertainty. The third IDSS focuses on equitable and efficient vaccine distribution, addressing demand uncertainties with a data-driven decision-making approach that significantly reduces shortages. Lastly, the fourth IDSS designs a robust and sustainable mask distribution and recycling network, balancing cost efficiency, environmental impact, and customer services. This research integrates exact methods (e.g., Parallelized Stochastic Dual Dynamic integer Programming (PSDDiP)), reinforcement learning, and hybrid optimization approaches, to enhance real-time resilient decision-making for large-scale SCs, while ensuring scalability, and computational efficiency. This is despite that most earlier IDSSs specifically reported for ”resilience” SC design, lack such integration, assume no disruptions, or they have not been assessed for large systems in real-time. The findings demonstrated the potential of resilient IDSSs to improve responsiveness, time management, and cost-effectiveness in selected SC networks. Addressing critical gaps in data availability during disruption events and dynamic adaptation of the decisions can also potentially provide practical new insights for policymakers and practitioners. For example, the proposed Online Reinforcement Driven Adoptive Optimization (ORDAO) showed the applicability to generate delivery tours to fulfill the same number of customer orders in almost 11% less delivery time in comparison to the Interactive Multi-Agent Simulation IMAS.
Supplementary document for Rapid quantum image scanning microscopy by joint sparse reconstruction - 4125922.pdf
Creators: name: Rossman, Uri
name: Tenne, Ron
name: Solomon, Oren
name: Kaplan-Ashiri, Ifat
name: Dadosh, Tali
name: Eldar, Yonina
name: Oron, Dan
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized
Optical Physics not elsewhere classified

description: Supplemental document
Towards obstacle reconstruction through wide baseline set of images
Creators: name: Elias, Rimon
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Artificial Intelligence.
subject: Computer Science.

description: In this thesis, we handle the problem of extracting 3D information from multiple images of a robotic work site in the context of teleoperation. A human operator determines the virtual path of a robotic vehicle and our mission is to provide him with the sequence of images that should be seen by the teleoperated robot moving along this path. The environment, in which the robotic vehicle moves, has a planar ground surface. In addition, a set of wide baseline images are available for the work site. This implies that a small number of points may be visible in more than two views. Moreover, camera parameters are known approximately. According to the sensor error margins, the parameters read lie within some range. Obstacles of different shapes are present in such an environment. In order to generate the sequence, this ground plane as well as the obstacles must be represented. The perspective image of the ground plane can be obtained through a homography matrix. This is done through the virtual camera parameters and the overhead view of the work site. In order to represent obstacles, we suggest different methods; these are volumetric and planar. Our algorithm to represent obstacles starts with detecting junctions. This is done through a new fast junction detection operator we propose. This operator provides the location of the junction as well as the orientations of the edges surrounding it. Junctions belonging to the obstacles are identified against those belonging to the ground plane through calculating the inter-image homography matrices. Fundamental matrices relating images can be estimated roughly through the available camera parameters. Strips surrounding epipolar lines are used as a search range for detecting possible matches. We introduce a novel homographic correlation method to be applied among candidates by reconstructing the planes of junctions in space. Two versions of homographic correlation are proposed; these are SAD and VNC. Both versions achieve matching results that outperform non-homographic correlation. The match set is then turned into a set of 3D points through triangulation. At this point, we propose a hierarchical structure to cluster points in space. This results in bounding boxes containing obstacles. A more accurate volumetric representation for the obstacle can be achieved through a voxelization approach. Another representation is suggested. That is to represent obstacles as planar patches. This is done through mapping among original and synthesized images. Finally, steps of the different algorithms presented throughout the thesis are supported by examples to show the usefulness we claim of our approaches.
IN THE POEMS OF AZHINIYAZ KOSYBAY ULY, THE PRAISE OF THE FATHERLAND
Creators: name: Amangeldieva, Alfiya
Publisher: name: Zenodo
Year: 2024

description: This article analyzes the artistic interpretation and ideological-artistic features of the homeland theme in the poetry of Ajhiniyaz Kosibay, a prominent figure in Karakalpak literature. The paper examines the poet's patriotic works, their artistic-aesthetic value, and contemporary significance.
Supplementary document for Picosecond pulses from a mid-infrared interband cascade laser - 4118836.pdf
Creators: name: Hillbrand, Johannes
name: Beiser, Maximilian
name: Andrews, Aaron
name: Detz, Hermann
name: Weih, Robert
name: Schade, Anne
name: Höfling, Sven
name: Strasser, Gottfried
name: Schwarz, Benedikt
Publisher: name: Optica Publishing Group
Year: 2019
Subjects: Lasers and Quantum Electronics

description: Supplemental document in answer to the reviewer comments
Pharmacovigilance in hospice/palliative care: Net effect of gabapentin for neuropathic pain
Creators: name: Sanderson, Christine
name: Quinn, Steve
name: Agar, Meera
name: Chye, Richard
name: Clark, Katherine
name: Doogue, Matthew
name: Fazekas, Belinda
name: Lee, Jessica
name: Lovell, Melanie R.
name: Rowett, Debra
name: Spruyt, Odette
name: Currow, David C.
Publisher: name: Swinburne
Year: 2024

description: Objective Hospice/palliative care patients may differ from better studied populations, and data from other populations cannot necessarily be extrapolated into hospice/palliative care clinical practice. Pharmacovigilance studies provide opportunities to understand the harms and benefits of medications in routine practice. Gabapentin, a [GAMMA]-amino butyric acid analogue antiepileptic drug, is commonly prescribed for neuropathic pain in hospice/palliative care. Most of the evidence however relates to non-malignant, chronic pain syndromes (diabetic neuropathy, postherpetic neuralgia, central pain syndromes, fibromyalgia). The aim of this study was to quantify the immediate and short-term clinical benefits and harms of gabapentin in routine hospice/palliative care practice. Design Multisite, prospective, consecutive cohort. Population 127 patients, 114 of whom had cancer, who started gabapentin for neuropathic pain as part of routine clinical care. Settings 42 centres from seven countries. Data were collected at three time points-at baseline, at day 7 (and at any time; immediate and short-term harms) and at day 21 (clinical benefits). Results At day 21, the average dose of gabapentin for those still using it (n=68) was 653 mg/24 h (range 0-1800 mg) and 54 (42%) reported benefits, of whom 7 (6%) experienced complete pain resolution. Harms were reported in 39/127 (30%) patients at day 7, the most frequent of which were cognitive disturbance, somnolence, nausea and dizziness. Ten patients had their medication ceased due to harms. The presence of significant comorbidities, higher dose and increasing age increased the likelihood of harm. Conclusions Overall, 42% of people experienced benefit at a level that resulted in continued use at 21 days.
Internet-Dienste sollen durch CO2-Label umweltfreundlicher werden
Creators: name: Siebert, David
Publisher: name: My University
Year: 2021

description: Im Corona-Lockdown hat der Datenverkehr deutlich zugenommen. Das bedeutet auch: höhere CO2-Emissionen. Forschende wollen den ökologischen Fußabdruck von Online-Diensten nun sichtbar machen. Quelle: https://www.swr.de/
Supplementary document for Integrated nanophotonic wavelength routers based on intelligent algorithm - 4110152.pdf
Creators: name: Liu, Zhouhui
name: Liu, Xiaohong
name: Xiao, Zhiyuan
name: Lu, Cuicui
name: Wang, Hui-Qin
name: Wu, You
name: Hu, Xiaoyong
name: Liu, Yong-Chun
name: Zhang, Hongyu
name: Zhang, Xiangdong
Publisher: name: Optica Publishing Group
Year: 2019
Subjects: Photonics, Optoelectronics and Optical Communications

description: Supplmentary Material
Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner
Creators: name: Chen, Chunqiu
name: Lu, Meiling
name: Pan, Qiuhui
name: Fichna, Jakub
name: Zheng, Lijun
name: Wang, Kesheng
name: Yu, Zhen
name: Li, Yongyu
name: Li, Kun
name: Song, Aihong
name: Liu, Zhongchen
name: Song, Zhenshun
name: Kreis, Martin
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Background and Aims Berberine and its derivatives display potent analgesic, anti-inflammatory and anticancer activity. Here we aimed at characterizing the mechanism of action of berberine in the gastrointestinal (GI) tract and cortical neurons using animal models and in vitro tests. Methods The effect of berberine was characterized in murine models mimicking diarrhea-predominant irritable bowel syndrome (IBS-D) symptoms. Then the opioidantagonists were used to identify the receptors involved. Furthermore, the effect of berberineon opioid receptors expression was established in the mouse intestine and rat fetal cortical neurons. Results In mouse models, berberine prolonged GI transit and time to diarrhea in a dose-dependent manner, and significantly reduced visceral pain. In physiological conditions the effects of berberine were mediated by mu- (MOR) and delta- (DOR) opioidreceptors; hypermotility, excessive secretion and nociception were reversed by berberine through MOR and DOR-dependent action. We also found that berberine increased the expression of MOR and DOR in the mouse bowel and rat fetal cortical neurons. Conclusion Berberine significantly improved IBS-D symptoms in animal models, possibly through mu- and delta- opioid receptors. Berberine may become a new drug candidate for the successful treatment of IBS-D in clinical conditions.
A Participatory Approach to Evaluating Strategies for Forest Carbon Mitigation in British Columbia
Creators: name: Peterson St-Laurent, Guillaume
name: Hoberg, George
name: Sheppard, S. R. J. (Stephen Richard John), 1952-
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: To be successful, actions for mitigating climate change in the forest and forest sector will not only need to be informed by the best available science, but will also require strong public and/or political acceptability. This paper presents the results of a novel analytical-deliberative engagement process that brings together stakeholders and Indigenous Peoples in participatory workshops in the interior and coastal regions of British Columbia (BC) to evaluate a set of potential forest carbon mitigation alternatives. In particular, this study examines what objectives are prioritized by stakeholders and Indigenous Peoples when discussing forest carbon mitigation in BC’s forests, as well as the perceived effectiveness of, and levels of support for, six forest-based carbon mitigation strategies. We start by describing the methodological framework involving two series of workshops. We then describe the results from the first round of workshops where participants identified 11 objectives that can be classified into four categories: biophysical, economic, social, and procedural. Afterwards, we discuss the second series of workshops, which allowed participants to evaluate six climate change mitigation strategies against the objectives previously identified, and highlight geographical differences, if any, between BC’s coastal and interior regions. Our results effectively illustrate the potential and efficacy of our novel methodology in informing a variety of stakeholders in different regions, and generating consistent results with a surprising degree of consensus on both key objectives and preference for mitigation alternatives. We conclude with policy recommendations on how to consider various management objectives during the design and implementation of forest carbon mitigation strategies.
Evidence for a dynamic corona in the short-term time lags of black hole X-ray binary MAXI J1820+070
Creators: name: Bollemeijer, Niek
name: Uttley, Phil
name: Basak, Arkadip
name: Ingram, Adam
name: Eijnden, Jakob van den
name: Alabarta, Kevin
name: Altamirano, Diego
name: Arzoumanian, Zaven
name: Buisson, Douglas J. K.
name: Fabian, Andrew C.
name: Ferrara, Elizabeth
name: Gendreau, Keith
name: Homan, Jeroen
name: Kara, Erin
name: Markwardt, Craig
name: Remillard, Ronald A.
name: Sanna, Andrea
name: Steiner, James F.
name: Tombesi, Francesco
name: Wang, Jingyi
name: Wang, Yanan
name: Zoghbi, Abderahmen
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: In X-ray observations of hard state black hole X-ray binaries, rapid variations in accretion disc and coronal power-law emission are correlated and show Fourier-frequency-dependent time lags. On short (~0.1 s) time-scales, these lags are thought to be due to reverberation and therefore may depend strongly on the geometry of the corona. Low-frequency quasi-periodic oscillations (QPOs) are variations in X-ray flux that have been suggested to arise because of geometric changes in the corona, possibly due to General Relativistic Lense-Thirring precession. Therefore one might expect the short-term time lags to vary on the QPO time-scale. We performed novel spectral-timing analyses on NICER observations of the black hole X-ray binary MAXI J1820+070 during the hard state of its outburst in 2018 to investigate how the short-term time lags between a disc-dominated and a coronal power-law-dominated energy band vary on different time-scales. Our method can distinguish between variability due to the QPO and broadband noise, and we find a linear correlation between the power-law flux and lag amplitude that is strongest at the QPO frequency. We also introduce a new method to resolve the QPO signal and determine the QPO-phase-dependence of the flux and lag variations, finding that both are very similar. Our results are consistent with a geometric origin of QPOs, but also provide evidence for a dynamic corona with a geometry varying in a similar way over a broad range of time-scales, not just the QPO time-scale.
description: 19 pages, 14 figures, 3 tables, published in MNRAS, includes link to reproduction package
Synthesis of glycopeptidomimetics of sialyl Lewis(x) and investigational studies of new processes
Creators: name: Schmor, Bradley J
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Chemistry, Organic.

description: The solution and solid-phase synthesis of N-linked fucopeptidomimetics of Sialyl Lewisx is described. The syntheses were successful to varying extents. It was determined that t-butyl deprotections are not compatible with the N-glycosidic linkage. This was overcome by the use of benzyl groups. A second series of syntheses were undertaken, involving tartaric acid as the hydroxyacid tail of the molecules. This convergent route was much more rapid, and molecular modelling studies suggested a good congruence with known binding conformations of the natural ligand. C-linked mimetics were also attempted, employing tartaric acid again as the polar tail source. Olefin cross-metathesis was also explored. The work in this area ultimately led to the discovery of a new palladium catalyzed phenyl transfer reaction from antimony. Glycosyl 1,2,3-triazoles were synthesized as glycosylproline analogues. The relative ratios of isomers were determined, and the structure of one analogue proven by Xray crystallography. Deprotection protocols were compatible with the triazolyl moiety. alpha/beta selectivity was observed in coupling protected fucosylamine with amino acids. The scope of the selectivity was examined in related systems. In addition, alpha/beta anomerization as catalyzed by protic acid was examined, and some insights about the mechanism can be gleaned from the results.
Aqueous and nonaqueous chemical approaches to elucidating structure and function in proteins.
Creators: name: Taralp, Alpay.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1997
Subjects: subject: Chemistry, Biochemistry.

description: Three chemical approaches were used to study proteins: Chemical modification with iodomethane: A novel strategy was developed in which proteins were simultaneously reacted with $\rm\lbrack \sp C\rbrack $ and $\rm\lbrack \sp C\rbrack $iodomethane to permit the identification of reactive groups by $\rm\lbrack \sp C\rbrack $NMR spectroscopy and the isolation of $\rm\lbrack \sp C\rbrack $labeled peptides containing individual methylated functional groups by autoradiography. Reaction with iodomethane N,N,N-trimethylated $\rm N\varepsilon$-lysyl and N-terminal $\rm N\alpha$-amino groups, $\rm N\sp1,N\sp3$-dimethylated imidazole functions of histidyl residues, O-methylated phenolic hydroxyl functions of tyrosyl residues and S-methylated sulphide functions of methionyl residues. Nonaqueous chemical modification techniques: Chemical modification of lyophilized proteins in nonaqueous environments was carried out by either dispersing protein in octane and reacting with dissolved reagent, or reacting protein in vacuo with a volatile reagent. The reaction of iodomethane with protein functional groups in nonaqueous environments and the derivatives formed paralleled those of aqueous reactions and were quantified by solution and solid state $\rm \lbrack \sp C\rbrack $NMR techniques. Reacting ethoxyformic anhydride or acetic anhydride with protein functional groups afforded acyl derivatives of $\rm N\alpha$ and $\rm N\varepsilon$-amino groups and mixed anhydrides of side-chain carboxyl groups. These mixed anhydrides were stable in the absence of water and enabled the coupling of protein to various nucleophiles. The extent of derivatization of functional groups of lyophilized protein was directly related to the $\rm pK\sb{a}$ of the reactive group, pH of the solution from which the protein was lyophilized, and extent of surface exposure of functional groups under native conditions. Enzyme kinetics: Five synthetic substrates containing different amino acid residues at the $\rm P\sb3$ position (acetyl-X-Arg-Arg-AMC, where X is Gly, Glu, Arg, Val and Tyr and where AMC represents 7-amido-4-methylcoumarin) were used to investigate the $\rm S\sb3$ subsite specificity of cathepsin B. At pH 6.0, the specificity constant, $k\sb{cat}/K\sb{\rm m},$ for tripeptide substrate hydrolysis was observed to increase in the order $\rm Glu Gly Arg Val Tyr.$ Molecular modeling studies of substrates containing a $\rm P\sb3$ Glu, Arg or Tyr covalently bound as the tetrahedral intermediate to cathepsin B suggest that enzyme specificity for a $\rm P\sb3$ Tyr group is due to a favourable aromatic-aromatic interaction with $\rm Tyr\sp{75}$ on the enzyme as well as a possible hydrogen bond between the $\rm P\sb3$ Tyr hydroxyl and the side-chain carboxyl of $\rm Asp\sp{69}.$ (Abstract shortened by UMI.)
Video quality measurement using digital watermarking
Creators: name: Wang, Sha
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Engineering, Electronics and Electrical.

description: A 3-level DWT (Discrete Wavelet Transform) based objective video quality measurement method is proposed based on semi-fragile digital watermarking. The watermark is embedded into the luminance components of the Intra frames of an MPEG-2 video stream, which can be treated as images. The degradation of the watermark is used to estimate the degradation of the cover work. A quantization method is used to embed the watermark. In the watermark embedding process, 10 quantization parameters are assigned to the 10 DWT decomposed blocks which are obtained by applying 3-level DWT to the target image. And the watermark is embedded with its vulnerability adjusted according to the different frequency distribution of the content of the cover work. Automatic control is used to adjust the watermark vulnerability which is controlled by the watermark bit portions and the quantization parameters. By referring to the ideal mapping curve which is the pre-calculated relationship between the quality in terms of the classical metrics and the True Detection Rates (TDR), the TDR and quality measurement (PSNR/wPSNR/Watson JND) relationship curve of any test image can be converged to the ideal mapping curve so that the quality of the degraded image can easily measured by checking the ideal mapping curve with the TDR computed during the watermark extraction. The TDR is calculated between the original watermark and the degraded watermark. After the watermark extraction, the degradation of the extracted watermark is used to estimate video/image quality in terms of the classical metrics. By comparing the video quality estimated by the proposed method with the calculated quality in terms of PSNR, wPSNR, and JND, it is clear that the proposed method can be used to evaluate video quality against compression with high accuracy.
Origin and implication of corona structures within diabase dykes intruding the Archean orthogneisses of the central Grenville Province, east of Chibougamau, Quebec.
Creators: name: Madore, Catherine.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1991
Subjects: subject: Geology.

description: Geological mapping has defined a distinct group of NNE trending diabase dykes east of the Grenville Front in the Chibougamau area. These dykes are found intruding Archean orthogneisses within a narrow zone, the Parautochthonous terrane, bounded to the northwest by the Grenville Front and to the southeast by the Allochthon Front. The best preserved dykes, exhibiting primary igneous minerals and textures, are located along the Grenville Front, whereas the most metamorphosed dykes (i.e. amphibolites) are located along the Allochthon Front. The dykes are tholeiizic to weakly alkaline and can be divided into four main groups, based on texture and certain major and trace elements: (1) low-TiO$\sb2$; (2) high-TiO$\sb2$; (3) high-TiO$\sb2$ segregations; and (4) high-Al$\sb2$O$\sb3$. Igneous minerals include olivine, augite, plagioclase, magnetite, biotite, and pargasite. The principal metamorphic minerals are enstatite, hornblende, spinel, corundum, garnet, albite, and quartz. (Abstract shortened by UMI.)
Modeling and simulation of cellular metabolism and energy production by mitochondria
Creators: name: Djafarzadeh, Roxana
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Engineering, Electronics and Electrical.

description: It is the intent of this thesis to investigate and develop a simulation model for metabolic pathways in the cells, namely, Glycolysis and Krebs cycle, using the DEVS formalism and the CD++ tool, then to further improve it to complete virtual mitochondrion. The hierarchical nature of DEVS makes it ideal for describing naturally hierarchical systems as the Cell, while its discrete-event approach improves performance due to the asynchronous nature of the events occurring in the cell. Simultaneously, as DEVS is a timed-based modeling approach, timing of the chemical reactions can be adequately represented. The models were developed using the CD++ toolkit, a modeling tool for simulation of complex physical systems that can be used to simulate a variety of models. CD++ server permits the execution and visualization of the results with sophisticated and easy-to-use Graphical User Interfaces. A precise and easy to use simulation environment for biological models of glycolysis and Krebs cycle was created, and the results presented show the potential of this approach.
Worlds apart? Sartre, Foucault, and the question of freedom
Creators: name: Brown, Mark Raymond
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Philosophy.

description: Readily acknowledged as two of the intellectual giants of twentieth century French thought, Jean-Paul Sartre and Michel Foucault are typically depicted as philosophical opposites. Sartre and Foucault are certainly distinct philosophers, but such a portrayal all too often obscures important similarities in their thought. This thesis, by arguing that Sartre and Foucault are not worlds apart on the question of freedom, attempts to bridge the distance that is commonly regarded to exist between these two. This task is accomplished by bringing to light specific affinities between Sartre and Foucault on the issue of freedom that occur at different junctures in their oeuvres. By proceeding with a critical intention in mind, this thesis provides an interpretative analysis that elucidates three important similarities between Sartre and Foucault: first, it will be shown that when Foucault, in his later thought, unequivocally raises the issue of freedom, he proposes an ethical orientation that is not markedly different from the one suggested by Sartre in his early existentialism. Both Sartre and Foucault put forth an ethical motive that relates to the creativity of the subject. It will be argued that this idea of creative freedom, implicit in Sartre's notion of authentic freedom and explicit in Foucault's proposal for an aesthetics of existence, can be related to an historical idea of artistic freedom, specifically, the autonomy that modern art promises. By showing that the concept of freedom which modern art presumes is a contentious issue, this thesis also argues that the idea of creative freedom in Sartre and Foucault is nothing less than an empty ethical suggestion. By tracing the theme of the gaze in Sartre and Foucault, the next motive will to be show that their thought is motivated by a similar recognition: the notion that humans gaze upon themselves and their world through an objective lens that limits freedom. It will be argued that this insight can be associated with another insight that Sartre and Foucault share: the idea that universal morality is impossible. Although morality, in the eyes of Sartre and Foucault, is impossible, it will be argued that their political activity, while not revealing a universal moral project, nevertheless discloses an ethical impetus. The final convergence that will be presented is that Sartre and Foucault, via different avenues, illustrate that freedom takes place in a socio-historical field that governs and determines its possibilities. Although this conclusion is a result of each thinker's engagement with history, it will be argued that neither Sartre or Foucault presents a convincing way out of this historical nightmare. In fact, by considering the implications of their refusal to introduce an idea of the good into the social field, it will be shown that both reduce the status of freedom to a negative concept.
Supplementary document for Coupled ptychography and tomography algorithm improves reconstruction of experimental data - 4120720.pdf
Creators: name: Kahnt, Maik
name: Becher, Joahnnes
name: Brückner, Dennis
name: Fam, Yakub
name: Sheppard, Thomas
name: Weissenberger, Tobias
name: Wittwer, Felix
name: Grunwaldt, Jan-Dierk
name: Schwieger, Wilhelm
name: Schroer, Christian
Publisher: name: Optica Publishing Group
Year: 2019
Subjects: Optical Physics not elsewhere classified

description: Supplemental Document
Automated sequential derivatization for GC-MS based  metabolite profiling of human blood
Creators: name: Jbebli, Akrem
Publisher: name: Zenodo
Year: 2024

description: Presentation given at Metabolomics 2024, June 16-20th, Osaka, Japan.
description: Generated within the European Environmental Exposure Assessment Research Infrastructure (EIRENE RI). Research Infrastructure RECETOX RI (No LM2023069) financed by the Ministry of Education, Youth and Sports, and Operational Programme Research, Development and Innovation – project CETOCOEN EXCELLENCE (No CZ.02.1.01/0.0/0.0/17_043/0009632).

The work was supported from project SALVAGE (CZ.02.01.01/00/22_008/0004644) financed by MEYS – Co-funded by the European Union