cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Typed Hilbert Epsilon Operators and the Semantics of Determiner Phrases (Invited Lecture)
Creators: name: Retoré, Christian
Publisher: name: arXiv
Year: 2014
Subjects: subject: Computation and Language (cs.CL)
subject: Artificial Intelligence (cs.AI)
subject: Logic in Computer Science (cs.LO)
subject: Logic (math.LO)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics
subject: 03B65, 03B15, 03B40, 68T50, 68N18

description: The semantics of determiner phrases, be they definite de- scriptions, indefinite descriptions or quantified noun phrases, is often as- sumed to be a fully solved question: common nouns are properties, and determiners are generalised quantifiers that apply to two predicates: the property corresponding to the common noun and the one corresponding to the verb phrase. We first present a criticism of this standard view. Firstly, the semantics of determiners does not follow the syntactical structure of the sentence. Secondly the standard interpretation of the indefinite article cannot ac- count for nominal sentences. Thirdly, the standard view misses the linguis- tic asymmetry between the two properties of a generalised quantifier. In the sequel, we propose a treatment of determiners and quantifiers as Hilbert terms in a richly typed system that we initially developed for lexical semantics, using a many sorted logic for semantical representations. We present this semantical framework called the Montagovian generative lexicon and show how these terms better match the syntactical structure and avoid the aforementioned problems of the standard approach. Hilbert terms rather differ from choice functions in that there is one polymorphic operator and not one operator per formula. They also open an intriguing connection between the logic for meaning assembly, the typed lambda calculus handling compositionality and the many-sorted logic for semantical representations. Furthermore epsilon terms naturally introduce type-judgements and confirm the claim that type judgment are a form of presupposition.
The Transforming Rho Family GTPase Wrch-1 Disrupts Epithelial Cell Tight Junctions and Epithelial Morphogenesis
Creators: name: Alan, J. K.
name: Fanning, A. S.
name: Brady, D. C.
name: Madigan, J. P.
name: Cox, A. D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Wrch-1, an atypical and transforming Rho GTPase, regulates cellular activities including proliferation and actin organization, but its functions and effectors remain poorly characterized. We show here that Wrch-1 distributes along the apical and basolateral membranes in MDCK cells and binds the cell polarity protein Par6 in a GTP-dependent manner. Activated Wrch-1 negatively regulates the kinetics of tight junction (TJ) assembly during epithelial cell polarization but has no detectable effect on overall cell polarity in confluent monolayers. It also causes a dramatic cytoskeletal reorganization and multilayering in cells grown in two-dimensional culture and disrupts cystogenesis of cells grown in three-dimensional (3D) culture. Similarly, short hairpin RNA-mediated knockdown of Wrch-1 perturbs cystogenesis in 3D culture, suggesting that tight regulation of Wrch-1 activity is necessary for normal epithelial morphogenesis. A weakly transforming effector domain mutant of activated Wrch-1 that inhibits Par6 binding abrogates the ability of Wrch-1 to disrupt TJ formation, actin organization, and epithelial morphogenesis. We hypothesize that Wrch-1-induced morphological and growth transformation may occur in part through Par6-mediated disruption of TJs and actin organization.
(:unas) unassigned
Creators: name: (:Unkn) Unknown
Publisher: name: Universita' degli Studi di Salerno
Year: 2024

description: Si pone in rilievo l’importanza decisiva nella produzione letteraria di Salvatore Quasimodo della sua realistica visione del processo storico come ininterrotto dominio della violenza, dai riti cruenti dei tempi arcaici ai moderni strumenti dell’apocalisse atomica, alla base di una resa espressiva ritmicamente dissonante e di un’intensa attività traduttiva non solo di poesia lirica, ma anche e soprattutto di opere tragiche, che diventano cifra semantica e linguistica della sua ispirazione civile, nel duplice aspetto di ritorno alla terra dei padri, il profondo Sud mediterraneo, evocato simbolicamente dal mito dell’aquila e il poeta, e utopicamente riscattato dall’uomo giusto, tale che possa operare per la pace, mettendo fine agli insensati orrori della guerra.
description: The decisive importance in the literary production of Salvatore Quasimodo is highlighted of his realistic vision of the historical process as an uninterrupted dominion of violence, from the bloody rites of archaic times to the modern instruments of the atomic apocalypse, at the basis of a rhythmically dissonant expressive rendering and of an intense translation activity not only of lyric poetry, but also and above all of tragic works, which become the semantic and linguistic cipher of his civil inspiration, in the dual aspect of return to the land of the fathers, the deep Mediterranean South, symbolically evoked by the myth of the eagle and the poet, and utopically redeemed by the just man, such that he can work for peace, putting an end to the senseless horrors of war.
Six Newly Discovered Eclipsing Binary Systems in the TESS field
Creators: name: Ulas, Burak
name: Ayan, Vildan
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present the first detailed investigation of six eclipsing binary systems in the TESS field. The TESS light curves of the targets are analysed by determining the initial effective temperatures via SED fits. The absolute parameters are derived and the systems are compared to well-known binaries of the same type. Results show that CD-58~791, CD-62~1257 and TYC~9356-355-1 are detached binary systems. CD-54~942 and UCAC4~136-007295 are contact binaries while TYC~8508-1413-1 is a semidetached system.
description: Accepted for publication in Research in Astronomy and Astrophysics. 16 pages, 9 figures
Atomically resolved imaging of ion-Implanted two-dimensional transition metal dichalcogenides
Creators: name: Hennessy, Michael
Publisher: name: University of Limerick
Year: 2023

description: Monolayer-thick transition metal dichalcogenides (TMDs) with the chemical formula MX2 (M = Mo, W; X = S, Se) constitute a new class of direct band gap semiconductors. They exhibit several favourable material properties, such as high mechanical flexibility, high photoresponsivity, and impressive electrical performance. Monolayer TMDs can also be incorporated into electrically driven devices, which in turn can be coupled to optical microcavities or photonic circuits. In order to continue the development of such technologies, however, new methods of material modification must be developed and tailored for application to these materials. One such technique is ultra-low energy ion implantation, which allows for highly pure, clean and selective substitutional incorporation of dopants.This method is compatible with standard semiconductor processing and offers an expanded selection of possible dopants compared to the other popular doping mechanisms. In this thesis, results of ultra-low energy (10 - 25 eV) ion implantation of mono-layer TMDs are reported. Successful implantation of foreign ions was achieved using the ADONIS mass-selected ion beam deposition system at the University of Göttingen . Transition metal (Cr) and chalcogen (S, Se) dopants were introduced into the MoS2 and MoSe2 crystal lattice. Atomic resolution high angle annular dark field (HAADF) scanning transmission electron microscopy (STEM) and core loss electron energy loss spectroscopy (EELS) were used to identify the sites of individual dopants in the host lattice and examine the atomic structure of the defects and dopants in the monolayers on the sub-atomic scale. Analysis of experimental HAADF STEM data was carried out using open source Python libraries to determine the percentage of ions that cause substitutional implantation, create adatoms, and create vacancies. The Model Refiner class from the TEMUL Toolkit Python package was developed to automatically identify and characterise each atomic site in the HAADF STEM image. Accurate atom statistics can be obtained from non-ideal STEM imaging conditions through post-processing and avoidance of contaminated areas when extracting atom sites. Furthermore, by simulating images based on the atomic arrangements determined via the software package, and by comparing these and achieving agreement with the experimental images, the individual atom positions of the dopants can be revealed with sub-Angstrom accuracy. This thesis constitutes part of a proof-of-principle study concerning the possibility and procedure of incorporating non-classical single photon emitting diodes into monolayer TMDs. The development of such devices has far-reaching implications for quantum science and technology, with applications in the fields of quantum cryptography and quantum metrology.
The mass fallback rate of the debris in relativistic stellar tidal disruption events
Creators: name: Jankovič, Taj
name: Gomboc, Andreja
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Highly energetic stellar tidal disruption events (TDEs) provide a way to study black hole characteristics and their environment. We simulate TDEs with the PHANTOM code in a general relativistic and Newtonian description of a supermassive black hole's gravity. Stars, which are placed on parabolic orbits with different parameters $β$, are constructed with the stellar evolution code MESA and therefore have realistic stellar density profiles. We study the mass fallback rate of the debris $\dot{M}$ and its dependence on the $β$, stellar mass and age as well as the black hole's spin and the choice of the gravity's description. We calculate peak value $\dot{M}_\mathrm{peak}$, time to the peak $t_\mathrm{peak}$, duration of the super-Eddington phase $t_\mathrm{Edd}$, time $t_{>0.5\dot{M}_\mathrm{peak}}$ during which $\dot{M}>0.5\dot{M}_\mathrm{peak}$, early rise-time $τ_\mathrm{rise}$ and late-time slope $n_\infty$. We recover the trends of $\dot{M}_\mathrm{peak}$, $t_\mathrm{peak}$, $τ_\mathrm{rise}$ and $n_\infty$ with $β$, stellar mass and age, which were obtained in previous studies. We find that $t_\mathrm{Edd}$, at a fixed $β$, scales primarily with the stellar mass, while $t_{>0.5\dot{M}_\mathrm{peak}}$ scales with the compactness of stars. The effect of SMBH's rotation depends on the orientation of its rotational axis relative to the direction of the stellar motion on the initial orbit. Encounters on prograde orbits result in narrower $\dot{M}$ curves with higher $\dot{M}_\mathrm{peak}$, while the opposite occurs for retrograde orbits. We find that disruptions, at the same pericenter distance, are stronger in a relativistic tidal field than in a Newtonian. Therefore, relativistic $\dot{M}$ curves have higher $\dot{M}_\mathrm{peak}$, and shorter $t_\mathrm{peak}$ and $t_\mathrm{Edd}$.
description: 18 pages, 11 figures, accepted for publication in ApJ
Three Proteins of the U7-Specific Sm Ring Function as the Molecular Ruler To Determine the Site of 3'-End Processing in Mammalian Histone Pre-mRNA
Creators: name: Torres, M. P.
name: Yang, X.-c.
name: Dominski, Z.
name: Marzluff, W. F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Cleavage of histone pre-mRNAs at the 3′ end is guided by the U7 snRNP, which is a component of a larger 3′-end processing complex. To identify other components of this complex, we isolated proteins that stably associate with a fragment of histone pre-mRNA containing all necessary processing elements and a biotin affinity tag at the 5′ end. Among the isolated proteins, we identified three well-characterized processing factors: the stem-loop binding protein (SLBP), which interacts with the stem-loop structure upstream of the cleavage site, and both Lsm11 and SmB, which are components of the U7-specifc Sm ring. We also identified 3′hExo/Eri-1, a multifunctional 3′ exonuclease that is known to trim the 3′ end of 5.8S rRNA. 3′hExo primarily binds to the downstream portion of the stem-loop structure in mature histone mRNA, with the upstream portion being occupied by SLBP. The two proteins bind their respective RNA sites in a cooperative manner, and 3′hExo can recruit SLBP to a mutant stem-loop that itself does not interact with SLBP. UV-cross-linking studies used to characterize interactions within the processing complex demonstrated that 3′hExo also interacts in a U7-dependent manner with unprocessed histone pre-mRNA. However, this interaction is not required for the cleavage reaction. The region between the cleavage site and the U7-binding site interacts with three low-molecular-weight proteins, which were identified as components of the U7-specific Sm core: SmB, SmD3, and Lsm10. These proteins likely rigidify the substrate and function as the molecular ruler in determining the site of cleavage.
Host Dark Matter Halos of WISE-selected Obscured & Unobscured Quasars: Evidence for Evolution
Creators: name: Petter, Grayson C.
name: Hickox, Ryan C.
name: Alexander, David M.
name: Myers, Adam D.
name: Geach, James E.
name: Whalen, Kelly E.
name: Andonie, Carolina P.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Obscuration in quasars may arise from steep viewing angles along the dusty torus, or instead may represent a distinct phase of supermassive black hole growth. We test these scenarios by probing the host dark matter halo environments of $\sim 1.4$ million WISE-selected obscured and unobscured quasars at $\langle z \rangle = 1.4$ using angular clustering measurements as well as cross-correlation measurements of quasar positions with the gravitational lensing of the cosmic microwave background (CMB). We interpret these signals within a halo occupation distribution (HOD) framework to conclude that obscured systems reside in more massive effective halos ($ \sim 10^{12.9} h^{-1} M_{\odot}$) than their unobscured counterparts ($ \sim 10^{12.6} h^{-1} M_{\odot}$), though we do not detect a difference in the satellite fraction. We find excellent agreement between the clustering and lensing analyses and show that this implies the observed difference is robust to uncertainties in the obscured quasar redshift distribution, highlighting the power of combining angular clustering and weak lensing measurements. This finding appears in tension with models that ascribe obscuration exclusively to orientation of the dusty torus along the line-of-sight, and instead may be consistent with the notion that some obscured quasars are attenuated by galaxy-scale or circumnuclear material during an evolutionary phase.
description: Accepted to The Astrophysical Journal
Trophoblast Stem Cell Maintenance by Fibroblast Growth Factor 4 Requires MEKK4 Activation of Jun N-Terminal Kinase
Creators: name: Abell, A. N.
name: Johnson, N. L.
name: Granger, D. A.
name: Dibble, C. F.
name: Johnson, G. L.
name: Vincent-Jordan, N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Trophoblast differentiation during placentation involves an epithelial-mesenchymal transition (EMT) with loss of E-cadherin and gain of trophoblast invasiveness. Mice harboring a point mutation that renders inactive the mitogen-activated protein kinase kinase kinase MEKK4 exhibit dysregulated placental development with increased trophoblast invasion. Isolated MEKK4 kinase-inactive trophoblast stem (TS) cells cultured under undifferentiating, self-renewing conditions in the presence of fibroblast growth factor 4 (FGF4) display increased expression of Slug, Twist, and matrix metalloproteinase 2 (MMP2), loss of E-cadherin, and hyperinvasion of extracellular matrix, each a hallmark of EMT. MEKK4 kinase-inactive TS cells show a preferential differentiation to Tpbpα- and Gcm1-positive trophoblasts, which are indicative of spongiotrophoblast and syncytiotrophoblast differentiation, respectively. FGF4-stimulated Jun N-terminal kinase (JNK) and p38 activity is markedly reduced in MEKK4 kinase-inactive TS cells. Chemical inhibition of JNK in wild-type TS cells induced a similar EMT response as loss of MEKK4 kinase activity, including inhibition of E-cadherin expression and increased expression of Slug, MMP2, Tpbpα, and Gcm1. Chromatin immunoprecipitation analyses revealed changes in AP-1 composition with increased Fra-2 and decreased Fra-1 and JunB binding to the regulatory regions of Gcm1 and MMP2 genes in MEKK4 kinase-inactive TS cells. Our results define MEKK4 as a signaling hub for FGF4 activation of JNK that is required for maintenance of TS cells in an undifferentiated state.
Aurora-A Phosphorylates, Activates, and Relocalizes the Small GTPase RalA
Creators: name: Brady, D. C.
name: Ancrile, B. B.
name: Cox, A. D.
name: Kashatus, D. F.
name: Lim, K.-H.
name: Der, C. J.
name: Counter, C. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The small GTPase Ras, which transmits extracellular signals to the cell, and the kinase Aurora-A, which promotes proper mitosis, can both be inappropriately activated in human tumors. Here, we show that Aurora-A in conjunction with oncogenic Ras enhances transformed cell growth. Furthermore, such transformation and in some cases also tumorigenesis depend upon S194 of RalA, a known Aurora-A phosphorylation site. Aurora-A promotes not only RalA activation but also translocation from the plasma membrane and activation of the effector protein RalBP1. Taken together, these data suggest that Aurora-A may converge upon oncogenic Ras signaling through RalA.
Convergence condition of simulated quantum annealing with a non-stoquastic catalyst
Creators: name: Kimura, Yusuke
name: Nishimori, Hidetoshi
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The Ising model with a transverse field and an antiferromagnetic transverse interaction is represented as a matrix in the computational basis with non-zero off-diagonal elements with both positive and negative signs and thus may be regarded to be non-stoquastic. We show that the local Boltzmann factors of such a system under an appropriate Suzuki-Trotter representation can be chosen non-negative and thus may potentially be simulated classically without a sign problem if the parameter values are limited to a subspace of the whole parameter space. We then derive conditions for parameters to satisfy asymptotically in order that simulated quantum annealing of this system converges to thermal equilibrium in the long-time limit.
description: 20 pages
Quantum spin-liquid behavior in the spin-1/2 random-bond Heisenberg antiferromagnet on the kagome lattice
Creators: name: Kawamura, Hikaru
name: Watanabe, Ken
name: Shimokawa, Tokuro
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: The effect of the quenched bond-randomness on the ordering of the $S=1/2$ antiferromagnetic Heisenberg model on the kagome lattice is investigated by means of an exact-diagonalization method. When the randomness exceeds a critical value, the ground state of the model exhibits a transition within the non-magnetic state into the randomness-relevant gapless spin-liquid state. Implications to the S=1/2 kagome-lattice antiferromagnet herbertsmithite is discussed.
description: Slight modifications in the text, two references added. To appear in J. Phys. Soc. Jpn
Hemiphlebia mirabilis Selys: new localities in Australia and perspectives on conservation (Zygoptera: Hemiphlebiidae)
Creators: name: Trueman, J. W. H
name: Hoye, G. A
name: Hawking, J. H
name: Watson, J. A. L
name: New, T. R
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

Until now, H. mirabilis was known to survive only at Wilsons Promontory, Victoria. However, although previously thought to have died out in the Goulburn Valley, also in Victoria, the sp. sill occurs there - on floodplain lagoons (billabongs) of the Goulburn R. at Alexandra, and lagoons of the tributary Yea R. at Yea, some 30 km downstream from Alexandra. More significant in terms of conservation is its discovery in Mt William National Park, NE Tasmania. H. mirabilis can no longer be regarded as an endangered sp.
Mitochondrial HEP27 Is a c-Myb Target Gene That Inhibits Mdm2 and Stabilizes p53
Creators: name: Zhang, Y.
name: Enomoto, T.
name: Deisenroth, C.
name: Thorner, A. R.
name: Perou, C. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The ever-expanding knowledge of the role of p53 in cellular metabolism, apoptosis, and cell cycle control has led to increasing interest in defining the stress response pathways that regulate Mdm2. In an effort to identify novel Mdm2 binding partners, we performed a large-scale immunoprecipitation of Mdm2 in the osteosarcoma U2OS cell line. One significant binding protein identified was Hep27, a member of the short-chain alcohol dehydrogenase/reductase (SDR) family of enzymes. Here, we demonstrate that the Hep27 preprotein contains an N-terminal mitochondrial targeting signal that is cleaved following mitochondrial import, resulting in mitochondrial matrix accumulation of mature Hep27. A fraction of the mitochondrial Hep27 translocates to the nucleus, where it binds to Mdm2 in the central domain, resulting in the attenuation of Mdm2-mediated p53 degradation. In addition, Hep27 is regulated at the transcriptional level by the proto-oncogene c-Myb and is required for c-Myb-induced p53 stabilization. Breast cancer gene expression analysis correlated estrogen receptor (ER) status with Hep27 expression and p53 function, providing a potential in vivo link between estrogen receptor signaling and p53 activity. Our data demonstrate a unique c-Myb-Hep27-Mdm2-p53 mitochondria-to-nucleus signaling pathway that may have functional significance for ER-positive breast cancers.
Additional file 2 of Seasonal responses and host uniqueness of gut microbiome of Japanese macaques in lowland Yakushima
Creators: name: Sawada, Akiko
name: Hayakawa, Takashi
name: Kurihara, Yosuke
name: Lee, Wanyi
name: Hanya, Goro
Publisher: name: figshare
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional file 2: Rarefaction curves on the number of detected ASVs with the increasing number of reads.
Internal Pressurization and Convective Gas Flow in Some Emergent Freshwater Macrophytes
Creators: name: Brix, Hans
name: Sorrell, Brian K
name: Orr, Philip T
Publisher: name: La Trobe
Year: 2023

description: MDFRC item.

Internal pressurization and convective through-flow are demonstrated to be common attributes of wetland plants with cylindrical culms or linear leaves. Eight of 14 species tested produced static internal gas pressure differentials of 200-1,300 Pa relative to ambient and internal convective airflows of 0.2 to > 10 cm3 min-1 culm-1, depending on species. Four species produced internal static pressure differentials of < 100 Pa. Two species did not pressurize. The driving forces are gradients in temperature and water vapor between the internal gas spaces of the plants and the ambient atmosphere (thermal transpiration and humidity-induced pressurization). A clear diel variation in pressurization and convective flow was observed; rates were highest in the afternoon and lowest at night, responding to ambient changes in light, temperature, and humidity. The resistance to airflow at the stem-rhizome junction was very high for some species, resulting in a low ability to convert internal pressurization into convective airflow through the rhizomes. Species with a high potential for internal pressurization and a low internal resistance to convective flow seem to have a competitive advantage over species that rely exclusively on diffusive gas transport, which allows them to grow in deeper waters.
Baryons in the Sakai-Sugimoto model in the D0-D4 background
Creators: name: Cai, Wenhe
name: Wu, Chao
name: Xiao, Zhiguang
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The baryon spectrum in the Sakai-Sugimoto model in the D4 background with smeared D0 charges is studied. We follow the instanton description of baryons by Hata et al.[Prog. Theor. Phys. 117, 1157]. The background corresponds to an excited state with nonzero glue condensate $\langle {\rm tr} (F_{μν}\tilde F^{μν})\rangle$ which is proportional to the D0 charge density. The baryon size shrinks when we turn on small D0 charge density. But for larger D0 charge density where massive modes in the gauge theory may also take effect, the size of baryons will grow. The difference between baryon masses will become smaller when D0 charge density increases. There may also be indications that the baryon will become unstable and cannot exist for sufficiently large D0 density.
description: 15 pages, 3 figures
Regulation of the Rho Family Small GTPase Wrch-1/RhoU by C-Terminal Tyrosine Phosphorylation Requires Src
Creators: name: Dewar, B. J.
name: Alan, J. K.
name: Cox, A. D.
name: Berzat, A. C.
name: Graves, L. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Wrch-1 is an atypical Rho family small GTPase with roles in migration, epithelial cell morphogenesis, osteoclastogenesis, and oncogenic transformation. Here, we observed rapid relocalization of Wrch-1 from the plasma membrane upon serum stimulation. Studies revealed a requirement for serum-stimulated tyrosine phosphorylation of Wrch-1 at residue Y254 within its C-terminal membrane targeting domain, mediated by the nonreceptor tyrosine kinase Src. Genetic or pharmacological loss of Src kinase activity blocked both phosphorylation and relocalization of Wrch-1. Functionally, Y254 was required for proper Wrch-1 modulation of cystogenesis in three-dimensional culture, and the phospho-deficient mutant, Y254F, was enhanced in Wrch-1-mediated anchorage-independent growth. Mechanistically, C-terminal tyrosine phosphorylation and subsequent relocalization of Wrch-1 downregulated its ability to interact with and activate its effectors by decreasing active Wrch-1-GTP, perhaps by altering proximity to a GEF or GAP. Phospho-deficient Wrch-1(Y254F) remained at the plasma membrane and GTP bound and continued to recruit and activate its effector PAK, even upon serum stimulation. In contrast, a phospho-mimetic mutant, Y254E, was constitutively endosomally localized and GDP bound and failed to recruit PAK unless mutated to be constitutively active/GAP insensitive. C-terminal tyrosine phosphorylation thus represents a new paradigm in posttranslational control of small GTPase localization, activation, and biological function.
Role of Septins in the Orientation of Forespore Membrane Extension during Sporulation in Fission Yeast
Creators: name: Asakawa, H.
name: Hirata, A.
name: Fukui, Y.
name: Koga, T.
name: Pringle, J. R.
name: Tachikawa, H.
name: Wu, J.-Q.
name: Nakamura, T.
name: Shimoda, C.
name: Onishi, M.
name: Bahler, J.
name: Takegawa, K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: During yeast sporulation, a forespore membrane (FSM) initiates at each spindle-pole body and extends to form the spore envelope. We used Schizosaccharomyces pombe to investigate the role of septins during this process. During the prior conjugation of haploid cells, the four vegetatively expressed septins (Spn1, Spn2, Spn3, and Spn4) coassemble at the fusion site and are necessary for its normal morphogenesis. Sporulation involves a different set of four septins (Spn2, Spn5, Spn6, and the atypical Spn7) that does not include the core subunits of the vegetative septin complex. The four sporulation septins form a complex in vitro and colocalize interdependently to a ring-shaped structure along each FSM, and septin mutations result in disoriented FSM extension. The septins and the leading-edge proteins appear to function in parallel to orient FSM extension. Spn2 and Spn7 bind to phosphatidylinositol 4-phosphate [PtdIns(4)P] in vitro, and PtdIns(4)P is enriched in the FSMs, suggesting that septins bind to the FSMs via this lipid. Cells expressing a mutant Spn2 protein unable to bind PtdIns(4)P still form extended septin structures, but these structures fail to associate with the FSMs, which are frequently disoriented. Thus, septins appear to form a scaffold that helps to guide the oriented extension of the FSM.
Symplekin Specifies Mitotic Fidelity by Supporting Microtubule Dynamics
Creators: name: Whitehurst, A. W.
name: Cappell, K. M.
name: Sciaky, N.
name: Larson, B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Using a pangenomic loss-of-function screening strategy, we have previously identified 76 potent modulators of paclitaxel responsiveness in non-small-cell lung cancer. The top hit isolated from this screen, symplekin, is a well-established component of the mRNA polyadenylation machinery. Here, we performed a high-resolution phenotypic analysis to reveal the mechanistic underpinnings by which symplekin depletion collaborates with paclitaxel. We find that symplekin supports faithful mitosis by contributing to the formation of a bipolar spindle apparatus. Depletion of symplekin attenuates microtubule polymerization activity as well as expression of the critical microtubule polymerization protein CKAP5 (TOGp). Depletion of additional members of the polyadenylation complex induces similar phenotypes, suggesting that polyadenylation machinery is intimately coupled to microtubule function and thus mitotic spindle formation. Importantly, tumor cells depleted of symplekin display reduced fecundity, but the mitotic defects that we observe are not evident in immortalized cells. These results demonstrate a critical connection between the polyadenylation machinery and mitosis and suggest that tumor cells have an enhanced dependency on these components for spindle assembly.
Additional file 4 of Seasonal responses and host uniqueness of gut microbiome of Japanese macaques in lowland Yakushima
Creators: name: Sawada, Akiko
name: Hayakawa, Takashi
name: Kurihara, Yosuke
name: Lee, Wanyi
name: Hanya, Goro
Publisher: name: figshare
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional file 4: Phylum, family and genus composition of the gut microbiome of Japanese macaques in the three dietary seasons.
Physiology of geosim production by Anabaena circinalis isolated from the Murrumbidgee River, Australia
Creators: name: Bowmer, K. H
name: Padovan, A
name: Oliver, R. L
name: Korth, W
name: Ganf, G. G
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

Chemical analysis and sensory assessment of river waters from the Murrumnidgee and Murray River showed geosim is an important odor compound. Experiments in culture using Anabaena circinalis isolated from the Murrumbidgee River, New South Wales, Australia showed that changes in chlorophyll per unit dry weight resulting from alterations in light intensity were parralleled by similar changes in geosim/dry weight such that geosim concentrations was correlated with chlorophyll a over an extreme range of light conditions. A. circinalis was a prolific producer of geosim, but a substantial proportion of the totla geosim was often retained intra-cellularly and released on sonication or treatment with copper. Therefore water treatment processes should avoid cell lysis.
The Function of Two Rho Family GTPases Is Determined by Distinct Patterns of Cell Surface Localization
Creators: name: Brennwald, P.
name: Wu, H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Rho family GTPases are critical regulators in determining and maintaining cell polarity. In Saccharomyces cerevisiae, Rho3 and Cdc42 play important but distinct roles in regulating polarized exocytosis and overall polarity. Cdc42 is highly polarized during bud emergence and is specifically required for exocytosis at this stage. In contrast, Rho3 appears to play an important role during the isotropic growth of larger buds. Using a novel monoclonal antibody against Rho3, we find that Rho3 localizes to the cell surface in a dispersed pattern which is clearly distinct from that of Cdc42. Using chimeric forms of these GTPases, we demonstrate that a small region at the N terminus is necessary and sufficient to confer Rho3 localization and function onto Cdc42. Analysis of this domain reveals two essential elements responsible for distinguishing function. First, palmitoylation of a cysteine residue by the Akr1 palmitoyltransferase is required both for the switch of function and the switch of localization properties of this domain. Second, two basic residues distal to the palmitoylation site are required for regulating binding affinity with the Exo70 and Sec3 effectors. This demonstrates the importance of localization and effector binding in determining how these GTPases evolved specific functions at distinct stages of polarized growth.
A Subset of Drosophila Integrator Proteins Is Essential for Efficient U7 snRNA and Spliceosomal snRNA 3'-End Formation
Creators: name: Waltenspiel, B.
name: Ezzeddine, N.
name: Albrecht, T.
name: Warren, W. D.
name: Chen, J.
name: Marzluff, W. F.
name: Burch, B.
name: Zhuo, M.
name: Wagner, E. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Proper gene expression relies on a class of ubiquitously expressed, uridine-rich small nuclear RNAs (snRNAs) transcribed by RNA polymerase II (RNAPII). Vertebrate snRNAs are transcribed from a unique promoter, which is required for proper 3′-end formation, and cleavage of the nascent transcript involves the activity of a poorly understood set of proteins called the Integrator complex. To examine 3′-end formation in Drosophila melanogaster, we developed a cell-based reporter that monitors aberrant 3′-end formation of snRNA through the gain in expression of green fluorescent protein (GFP). We used this reporter in Drosophila S2 cells to determine requirements for U7 snRNA 3′-end formation and found that processing was strongly dependent upon nucleotides located within the 3′ stem-loop as well as sequences likely to comprise the Drosophila equivalent of the vertebrate 3′ box. Substitution of the actin promoter for the snRNA promoter abolished proper 3′-end formation, demonstrating the conserved requirement for an snRNA promoter in Drosophila. We tested the requirement for all Drosophila Integrator subunits and found that Integrators 1, 4, 9, and 11 were essential for 3′-end formation and that Integrators 3 and 10 may be dispensable for processing. Depletion of cleavage and polyadenylation factors or of histone pre-mRNA processing factors did not affect U7 snRNA processing efficiency, demonstrating that the Integrator complex does not share components with the mRNA 3′-end processing machinery. Finally, flies harboring mutations in either Integrator 4 or 7 fail to complete development and accumulate significant levels of misprocessed snRNA in the larval stages.
Desorption Dynamics of Heavy Alkali Metal Atoms (Rb, Cs) off the Surface of Helium Nanodroplets
Creators: name: von Vangerow, J.
name: Sieg, A.
name: Stienkemeier, F.
name: Mudrich, M.
name: Leal, A.
name: Mateo, D.
name: Hernando, A.
name: Barranco, M.
name: Pi, M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Atomic and Molecular Clusters (physics.atm-clus)
subject: FOS: Physical sciences

description: We present a combined ion imaging and density functional theory study of the dynamics of the desorption process of rubidium and cesium atoms off the surface of helium nanodroplets upon excitation of the perturbed $6s$ and $7s$ states, respectively. Both experimental and theoretical results are well represented by the pseudodiatomic model for effective masses of the helium droplet in the desorption reaction of m_eff/m_He~10 (Rb) and 13 (Cs). Deviations from this model are found for Rb excited to the 6p state. Photoelectron spectra indicate that the dopant-droplet interaction induces relaxation into low-lying electronic states of the desorbed atoms in the course of the ejection process.
description: in press, J. Phys. Chem. A (2014)
Brief Jodoco Pfiffero
Creators: name: Staal, Hans Jakob von
Publisher: name: [s.n.]
Year: 1599

description: von Jo[hann] Jac[obus vom] Staal
description: Brief Nr. 348.
description: Lateinisch
description: Verzeichnung=Description=Inventaire August 2016/August 2022 HAN-Katalogisierungsregeln iho/HBr
FLASH Is Required for the Endonucleolytic Cleavage of Histone Pre-mRNAs but Is Dispensable for the 5' Exonucleolytic Degradation of the Downstream Cleavage Product
Creators: name: Sabath, I.
name: Kunduru, L.
name: Xu, B.
name: Dominski, Z.
name: Marzluff, W. F.
name: Yang, X.-c.
name: Burch, B. D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: 3′-end cleavage of histone pre-mRNAs is catalyzed by CPSF-73 and requires the interaction of two U7 snRNP-associated proteins, FLASH and Lsm11. Here, by using scanning mutagenesis we identify critical residues in human FLASH and Lsm11 that are involved in the interaction between these two proteins. We also demonstrate that mutations in the region of FLASH located between amino acids 50 and 99 do not affect binding of Lsm11. Interestingly, these mutations convert FLASH into an inhibitory protein that reduces in vitro processing efficiency of highly active nuclear extracts. Our results suggest that this region in FLASH in conjunction with Lsm11 is involved in recruiting a yet-unknown processing factor(s) to histone pre-mRNA. Following endonucleolytic cleavage of histone pre-mRNA, the downstream cleavage product (DCP) is degraded by the 5′–3′ exonuclease activity of CPSF-73, which also depends on Lsm11. Strikingly, while cleavage of histone pre-mRNA is stimulated by FLASH and inhibited by both dominant negative mutants of FLASH and anti-FLASH antibodies, the 5′–3′ degradation of the DCP is not affected. Thus, the recruitment of FLASH to the processing complex plays a critical role in activating the endonuclease mode of CPSF-73 but is dispensable for its 5′–3′ exonuclease activity. These results suggest that CPSF-73, the catalytic component in both reactions, can be recruited to histone pre-mRNA largely in a manner independent of FLASH, possibly by a separate domain in Lsm11.
Additional file 5 of Seasonal responses and host uniqueness of gut microbiome of Japanese macaques in lowland Yakushima
Creators: name: Sawada, Akiko
name: Hayakawa, Takashi
name: Kurihara, Yosuke
name: Lee, Wanyi
name: Hanya, Goro
Publisher: name: figshare
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional file 5: Results of cluster analysis on the monthly variations of dietary composition of three focal female Japanese macaques.
The development of Agrarian and industrial complex of the Amur region and measures of the State support
Creators: name: Hudoleev Vitaly Petrovich
Publisher: name: Дальневосточный аграрный вестник
Year: 2011
Subjects: ПОСЕВНАЯ ПЛОЩАДЬ
ВАЛОВОЙ СБОР
СОРТОСМЕНА
СОРТООБНОВЛЕНИЕ
ПЛЕМЕННОЙ СКОТ
ЖИВОТНОВОДЧЕСКИЕ КОМПЛЕКСЫ
СОЦИАЛЬНЫЕ ВЫПЛАТЫ
ГОСУДАРСТВЕННАЯ ПОДДЕРЖКА

description: Are summed up agricultural year in Priamure, shows the ways of development of agrarian and industrial complex and measures of the state support of agricultural commodity producer The special attention is given the realization “Social village`s development ” program.
Matrix and tensor witnesses of hidden symmetry algebras
Creators: name: Ramgoolam, Sanjaye
name: Sword, Lewis
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Representation Theory (math.RT)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: Permutation group algebras, and their generalizations called permutation centralizer algebras (PCAs), play a central role as hidden symmetries in the combinatorics of large $N$ gauge theories and matrix models with manifest continuous gauge symmetries. Polynomial functions invariant under the manifest symmetries are the observables of interest and have applications in AdS/CFT. We compute such correlators in the presence of matrix or tensor witnesses, which by definition, can include a matrix or tensor field appearing as a coupling in the action (i.e a spurion) or as a classical (un-integrated) field in the observables, appearing alongside quantum (integrated) fields. In both matrix and tensor cases we find that two-point correlators of general gauge-invariant observables can be written in terms of gauge invariant functions of the witness fields, with coefficients given by structure constants of the associated PCAs. Fourier transformation on the relevant PCAs, relates combinatorial bases to representation theoretic bases. The representation theory basis elements obey orthogonality results for the two-point correlators which generalise known orthogonality relations to the case with witness fields. The new orthogonality equations involve two representation basis elements for observables as input and a representation basis observable constructed purely from witness fields as the output. These equations extend known equations in the super-integrability programme initiated by Mironov and Morozov, and are a direct physical realization of the Wedderburn-Artin decompositions of the hidden permutation centralizer algebras of matrix/tensor models.
description: 53 pages + Appendices, 9 Figures
Brief an [Eduard] Roeckel
Creators: name: Spohr, Louis
Publisher: name: [s.n.]
Year: 1838

description: von Louis Spohr
description: Beim Adressaten handelt es sich angesichts der Londoner Adresse vermutlich um Eduard Roeckel (1816-1899).
description: Deutsch
description: Den Brief erhielt Cäsar von Arx gemäss seinen eigenen beiliegenden Notizen im März 1938 von Carl Geigy-Hagenbach geschenkt.
description: Verzeichnung=Description=Inventaire November 2016 Neuaufnahme HBr
Mouse Cardiac Acyl Coenzyme A Synthetase 1 Deficiency Impairs Fatty Acid Oxidation and Induces Cardiac Hypertrophy
Creators: name: Watkins, S. M.
name: Shulman, G. I.
name: Willis, M. S.
name: Ellis, J. M.
name: DePetrillo, M. A.
name: Muoio, D. M.
name: Koves, T. R.
name: Mentock, S. M.
name: Taegtmeyer, H.
name: Sen, S.
name: Coleman, R. A.
name: Cline, G. W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Long-chain acyl coenzyme A (acyl-CoA) synthetase isoform 1 (ACSL1) catalyzes the synthesis of acyl-CoA from long-chain fatty acids and contributes the majority of cardiac long-chain acyl-CoA synthetase activity. To understand its functional role in the heart, we studied mice lacking ACSL1 globally (Acsl1T−/−) and mice lacking ACSL1 in heart ventricles (Acsl1H−/−) at different times. Compared to littermate controls, heart ventricular ACSL activity in Acsl1T−/− mice was reduced more than 90%, acyl-CoA content was 65% lower, and long-chain acyl-carnitine content was 80 to 90% lower. The rate of [14C]palmitate oxidation in both heart homogenate and mitochondria was 90% lower than in the controls, and the maximal rates of [14C]pyruvate and [14C]glucose oxidation were each 20% higher. The mitochondrial area was 54% greater than in the controls with twice as much mitochondrial DNA, and the mRNA abundance of Pgc1α and Errα increased by 100% and 41%, respectively. Compared to the controls, Acsl1T−/− and Acsl1H−/− hearts were hypertrophied, and the phosphorylation of S6 kinase, a target of mammalian target of rapamycin (mTOR) kinase, increased 5-fold. Our data suggest that ACSL1 is required to synthesize the acyl-CoAs that are oxidized by the heart, and that without ACSL1, diminished fatty acid (FA) oxidation and compensatory catabolism of glucose and amino acids lead to mTOR activation and cardiac hypertrophy without lipid accumulation or immediate cardiac dysfunction.
Bulk superconductivity in single phase Bi3O2S3
Creators: name: Shao, Jifeng
name: Liu, Zhongheng
name: Yao, Xiong
name: Pi, Li
name: Tan, Shun
name: Zhang, Changjin
name: Zhang, Yuheng
Publisher: name: arXiv
Year: 2014
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We report the synthesis of single phase Bi3O2S3 sample and confirm the occurrence of bulk superconductivity with transition temperature at 5.8 K. The Bi3O2S3 super-conductor is categorized as the typical type-II supercon-ductor based on the results of both temperature and mag-netic field dependences of magnetization. Hall coefficient measurements give evidence of a multiband character, with a dominant conduction mainly by electron-like charge carriers. The charge carrier density is about 1.45 X 1019 cm3, suggesting that the system has very low charge carrier density.
description: 4 pages, 5 figures, accepted for publication in Physica Status Solidi (RRL) - Rapid Research Letters
Eccentricity generation in hierarchical triple systems with coplanar and initially circular orbits
Creators: name: Georgakarakos, Nikolaos
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We develop a technique for estimating the inner eccentricity in hierarchical triple systems with well separated components. We investigate systems with initially circular and coplanar orbits and comparable masses. The technique is based on an expansion of the rate of change of the Runge-Lenz vector for calculating short period terms by using first order perturbation theory. The combination of the short period terms with terms arising from octupole level secular theory, results in the derivation of a rather simple formula for the eccentricity of the inner binary. The theoretical results are tested against numerical integrations of the full equations of motion. Comparison is also made with other results on the subject.
description: This is a preprint of an article published in MNRAS in 2002. arXiv admin note: text overlap with arXiv:0811.1146
Brief an Antoine Etex
Creators: name: Donizetti, Gaetano
Publisher: name: [s.n.]
Year: 1843

description: von [Gaetano] Donizetti
description: Anrede: Messieurs. Datierung und Ermittlung des Adressaten aufgrund einer Auskunft von Prof. Paolo Fabbri, Fondazione Donizetti, Bergamo, September 2020.
description: Französisch
description: Den Brief erhielt Cäsar von Arx gemäss seinen beiliegenden Notizen im März 1938 von Carl Geigy-Hagenbach geschenkt.
description: Verzeichnung=Description=Inventaire November 2016 Neuaufnahme HBr