cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Molecular genetic and biochemical studies of cis-prenyltransferase and small rubber particle protein for natural rubber biosynthesis in lettuce (Lactuca saliva)
Creators: name: Qu, Yang
Publisher: name: Graduate Studies
Year: 2013
Subjects: subject: General
subject: natural rubber
subject: cis-prenyltransferase
subject: small rubber particle protein

description: Plant derived metabolites have been extensively implicated in medication and industry. Natural rubber (cis-1,4-polyisoprene) has become one of the most important raw materials since the rise of automotive industry due to its elastic characteristics. Despite the invention of synthetic elastomers, the demand and production of natural rubber has been increasing because it has higher polymer properties such as elasticity, resilience, abrasion and heat dispersion. Natural rubber belongs to the metabolites family termed isoprenoid that is synthesized from the same precursor isopentenyl pyrophosphate (IPP). Natural rubber is classified in a subgroup of linear molecules condensed from various IPP in cis-stereochemistry called cis- polyisoprenoids. The responsible enzyme is termed cis-prenyltransferase (CPT). Bacterial CPTs have been extensively studied in both biochemistry and 3D structure. Eukaryotic CPTs are not studied in such detail. They are not enzymatically active when purified, and the activity requires biomembrane and/or other undetermined membrane associated proteins. Based on natural rubber structure, CPT is suggested in the biosynthesis of this extremely long-chain cis-polyisoprenoid. However, there had not been convincing experimental evidence at the beginning of this study. Using proteomics, next-generation-sequencing, RNAi-silencing, and protein-protein interaction study, we identified two key proteins directly involved in the natural rubber biosynthesis in rubber producing plant lettuce (Lactuca sativa). RNAi silencing of CPT-like gene CPT Scaffold protein 2 (CSF2) resulted in robust decrease of natural rubber in planta. CSF2 interacts with a regular CPT (CPT3), and this interaction mutually influences the subcellular localization of both proteins. In agreement with the recently reported human dolichol synthase comprising both CSF and CPT partners, our data suggests the previously unknown heterodimeric synthase infrastructure may be conserved in eukaryotic long-chain cis-polyisoprenoid synthesis. Rubber Elongation Factor (REF) and its closely related homolog Small Rubber Particle Protein (SRPP) have also been implicated in natural rubber synthesis, despite the lack of convincing evidence. RNAi-silencing of their orthologs (lettuce SRPPs) in planta instead suggests that they are not crucial in the natural rubber synthesis. For the first time, CPT-like gene CSF is shown indispensible in natural rubber synthesis. The discovery of the interaction between CSF and CPT has built the molecular base for future improvement of natural rubber production and the eventual reconstitution of natural rubber synthesis in other organism at industrial scale.
The low-density lipoprotein receptor knock-out mouse : a model for the study of energy balance
Creators: name: Ngai, Ying Fai Tiffany
Publisher: name: University of British Columbia
Year: 2010

description: The discovery of leptin and other humoral signals which regulate food intake and energy expenditure has greatly contributed to our understanding of molecular pathways controlling energy homeostasis. Leptin produced by adipocytes, insulin produced by the pancreas, and ghrelin produced by the stomach all contribute to the body’s energy balance. One question remaining is whether the lipid transport system also plays a role. Our hypothesis is that lipid clearance is important in the maintenance of energy homeostasis. The low-density lipoprotein receptor (Ldlr) is a key molecule involved with lipid clearance. The experiments presented in this thesis used the Ldlr-/- mouse to study the Ldlr’s role in energy balance. One aim of this thesis was to provide a detailed analysis of the energy balance phenotype of the Ldlr-/- mouse. Another aim of this thesis was to use the Ldlr-/- mouse to study the potential interaction between Ldlr and the leptin signaling pathway. Adult Ldlr-/- mice and Ldlr+/+ controls on a C57BL/6J background were fed either a chow or a high-fat, high-sucrose Western-type diet (WTD) for eight weeks. Physiological studies of food intake, energy expenditure, activity, heat production, insulin sensitivity, and leptin responsiveness were performed. As well, the effect of these diet interventions on circulating leptin and on leptin gene expression was examined. On the chow diet, Ldlr-/- mice had lower energy expenditure and higher activity levels relative to controls. On the WTD, Ldlr-/- mice gained less weight relative to Ldlr+/+ mice, specifically gaining less fat mass. Increased thermogenesis in Ldlr-/- mice fed the WTD was detected. Additionally, leptin responsiveness was blunted in chow-fed Ldlr-/- mice, suggesting a novel role for the Ldlr pathway that extends to leptin’s regulation of energy balance. In addition to its known role in lipid transport, these results from the Ldlr-/- mouse demonstrate the importance of the Ldlr in regulating energy homeostasis and suggest a direct physiological link between dyslipidemia and energy balance.
Fixed Price of Groups and Percolation
Creators: name: Lyons, Russell
Publisher: name: arXiv
Year: 2011
Subjects: subject: Dynamical Systems (math.DS)
subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 22F10, 60K35

description: We prove that for every finitely generated group $Γ$, at least one of the following holds: (1) $Γ$ has fixed price; (2) each of its Cayley graphs $G$ has infinitely many infinite clusters for some Bernoulli percolation on $G$.
description: 3 pp
Phase Partitioning and Thermo-physical Properties of Athabasca Bitumen / Solvent Mixtures
Creators: name: Nourozieh, Hossein
Publisher: name: Graduate Studies
Year: 2013
Subjects: subject: Petroleum
subject: Bitumen
subject: Solvent
subject: Thermodynamics
subject: Phase Behaviour

description: The phase behaviour and thermo-physical properties of bitumen/solvent systems are of crucial importance for heavy oil and bitumen in-situ recovery methods as well as pipeline transportation, surface upgrading, and refining. The equilibrium properties of mixtures containing heavy oil are also important for the development of numerical simulators, the application of various thermal and non-thermal recovery processes, and the application of fluid extraction processes. The main objective of this study was the development of a comprehensive understanding of the phase behaviour of bitumen/solvent mixtures. A new pressure-volume-temperature (PVT) apparatus was designed and constructed to acquire experimental data for the phase behaviour of bitumen/solvent mixtures and their thermo-physical properties. A new methodology for phase detection and accurate volume measurements was proposed for obtaining single liquid, vapour-liquid, and liquid-liquid equilibrium properties as well as the extraction yield for bitumen/solvent systems. New vapour-liquid and liquid-liquid equilibrium data for Athabasca bitumen / ethane and Athabasca bitumen / propane mixtures were experimentally acquired and corresponding phase diagrams were generated over wide ranges of temperatures and pressures. The effect of different parameters, such as the solvent-to-oil ratio, pressure, and temperature, on equilibrium phase compositions, saturated phase properties (density and viscosity), and the distribution of fractions in different phases were studied. The optimal solvent for bitumen viscosity reduction was identified at different operating conditions. The potential applications of ethane and propane for the supercritical and subcritical extraction of valuable components from bitumen were also experimentally evaluated. The generated data were then modelled with the Peng-Robinson equation of state to accurately predict the phase boundaries and phase compositions. New measurements for thermo-physical properties of Athabasca bitumen / n-hexane and Athabasca bitumen / condensate mixtures were conducted at different temperatures, pressures, and solvent weight fractions. The mixture density and viscosity data were evaluated with predictive schemes as well as with correlation models representing certain mixing rules proposed in the literature. The influences of pressure, temperature, and solvent weight fraction on the density and viscosity of mixtures were considered in the models and evaluated from the experimental results.
Importance of the Initial Conditions for Star Formation - III: Statistical Properties of Embedded Protostellar Clusters
Creators: name: Girichidis, Philipp
name: Federrath, Christoph
name: Allison, Richard
name: Banerjee, Robi
name: Klessen, Ralf
Publisher: name: arXiv
Year: 2011
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We investigate the formation of protostellar clusters during the collapse of dense molecular cloud cores with a focus on the evolution of potential and kinetic energy, the degree of substructure, and the early phase of mass segregation. Our study is based on a series of hydrodynamic simulations of dense cores, where we vary the initial density profile and the initial turbulent velocity. In the three-dimensional adaptive mesh refinement simulations, we follow the dynamical formation of filaments and protostars until a star formation efficiency of 20%. Despite the different initial configurations, the global ensemble of all protostars in a setup shows a similar energy evolution and forms sub-virial clusters with an energy ratio $E_\mathrm{kin}/|E_\mathrm{pot}|\sim0.2$. Concentrating on the innermost central region, the clusters show a roughly virialised energy balance. However, the region of virial balance only covers the innermost $\sim10-30%$ of all the protostars. In all simulations with multiple protostars, the total kinetic energy of the protostars is higher than the kinetic energy of the gas cloud, although the protostars only contain 20% of the total mass. The clusters vary significantly in size, mass, and number of protostars, and show different degrees of substructure and mass segregation. Flat density profiles and compressive turbulent modes produce more subclusters then centrally concentrated profiles and solenoidal turbulence. We find that dynamical relaxation and hence dynamical mass segregation is very efficient in all cases from the very beginning of the nascent cluster, i.e., during a phase when protostars are constantly forming and accreting.
description: 19 pages, MNRAS accepted
On the nature of candidate luminous blue variables in M33
Creators: name: Clark, J. S.
name: Castro, N.
name: Garcia, M.
name: Herrero, A.
name: Najarro, F.
name: Negueruela, I.
name: Ritchie, B. W.
name: Smith, K. T.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Luminous blue variables (LBVs) are expected to play an important role in massive stellar evolution as well as being the progenitors of some of the most luminous supernovae known. In this paper we provide a multiwavelength study of the population of (candidate) LBVs identified within M33. New spectra provide an observational baseline of >4yr with respect to published data, which is well suited to identifying LBV outbursts. Multi-epoch optical and mid-IR surveys of M33 further constrain the variability of the sample and permit a search for dusty circumstellar ejecta. Spectroscopic and photometric variability appears common amongst the sample, although in many cases further observations will be required to determine its physical origin. Nevertheless, we report a new outburst of M33 Var C, while the transition of the WNLh star B517 to a cooler B supergiant phase between 1993-2010 confirms an LBV classification. Proof-of-concept quantitative analysis is provided for Romano's star; the results being consistent with the finding that its bolometric luminosity varies during its LBV excursions. The combination of the temperature and luminosity of two stars, the B hypergiant [HS80] 110A and the cool hypergiant B324, appears to be in violation of the empirical Humphreys-Davidson limit. Mid-IR observations demonstrate that a number of candidates appear associated with hot circumstellar dust, although no objects as extreme as Eta Carinae are identified. The combined multiwavelength dataset suggests that the population of LBVs studied is contaminated by stars demonstrating the B[e] phenomenon. Of these, a subset of optically faint, low luminosity stars associated with hot dust are of particular interest since they appear similar to the likely progenitors of SN 2008S and the 2008 NGC300 transient, albeit suffering less intrinsic extinction. [ABRIDGED]
description: 23 pages, 14 figures, accepted for publication in Astronomy and Astrophysics
The Discovery of an Ultra-Faint Star Cluster in the Constellation of Ursa Minor
Creators: name: Munoz, Ricardo R.
name: Geha, Marla
name: Cote, Patrick
name: Vargas, Luis
name: Santana, Felipe A.
name: Stetson, Peter
name: Simon, Josh D.
name: Djorgovski, S. George
Publisher: name: arXiv
Year: 2012
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We report the discovery of a new ultra-faint globular cluster in the constellation of Ursa Minor, based on stellar photometry from the MegaCam imager at the Canada-France-Hawaii Telescope (CFHT). We find that this cluster, Munoz 1, is located at a distance of 45 +/- 5 kpc and at a projected distance of only 45 arcmin from the center of the Ursa Minor dSph galaxy. Using a Maximum Likelihood technique we measure a half-light radius of 0.5 arcmin, or equivalently 7 pc and an ellipticity consistent with being zero. We estimate its absolute magnitude to be M_V=-0.4 +/- 0.9, which corresponds to L_V=120 (+160, -65) L_sun and we measure a heliocentric radial velocity of -137 +/- 4 km/s based on Keck/DEIMOS spectroscopy. This new satellite is separate from Ursa Minor by ~30 kpc and 110 km/s suggesting the cluster is not obviously associated with the dSph, despite the very close angular separation. Based on its photometric properties and structural parameters we conclude that Munoz 1 is a new ultra-faint stellar cluster. Along with Segue 3 this is one of the faintest stellar clusters known to date.
description: Accepted for publication in ApJ Letters
The response of human synovial progenitor cells in a tissue-engineered construct to mechanical loading
Creators: name: Buckley-Herd, Geoffrey Bryce
Publisher: name: Graduate Studies
Year: 2013
Subjects: subject: Cell
subject: Biomedical
subject: stem cell tissue engineering
subject: synovial progenitor
subject: tissue-engineered cartilage
subject: mechanical loading
subject: donor variability

description: Background - Existing therapies for joint injury and osteoarthritis generally fail to restore the biomechanical equilibrium that is critical to joint homeostasis. The potential of cartilage tissue engineering using autologous stem cells is a promising fi eld, but much remains to be understood. In particular, mechanical loading as a means of directing stem cell behaviour is an area of great interest. Methods - Exogenous scaff old-free tissue-engineered constructs were generated from human synovial membrane and/or fluid-derived mesenchymal progenitor cells from five diff erent donors. Cell monolayers were treated with either ascorbic acid-supplemented (AA) media or chondrogenic diff erentiation media, causing matrix deposition that could be aggregated into constructs. The aggregated constructs were then subjected to con fined compressive loading. Results - Constructs were successfully generated using both methods. Gene expression markers of chondrogenic diff erentiation were substantially di erent from controls, but varied dramatically between constructs and donors. The generated constructs exhibited a complex, heterogeneous structure under histological analysis that stained positively for cartilage markers regardless of loading. Conclusions - The findings of this study likely indicate that the constructs retained their chondrogenic potential following construct generation and highlight the utility of mechanical loading in directing di fferentiation in tissue-engineered constructs. They also emphasize some of the challenges presented by the variability in donor tissues, and may serve as a useful platform for future studies investigating the generation of autologous tissue-engineered cartilage.
CO2 Sequestration in UCG
Creators: name: Adim Naghouni, Forough
Publisher: name: Graduate Studies
Year: 2013
Subjects: subject: Petroleum
subject: Forough

description: The most commonly applied UCG designs are Linked Vertical Wells (LVW) and Controlled Retracting Injection Point (CRIP). In the CRIP process, the production well is drilled vertically, and the injector is drilled horizontally close enough to the producer to have considerable flow connection. When the linking channel is established, the coal is ignited at the end of the horizontal well and a cavity is initiated. A main problem with UCG in contrast to other fossil fuel technologies is the higher CO2 production which may lead to a global warming potential. Potential solutions for this problem may be compression and injection of the recovered CO2 into an exhausted UCG reactor or into a seam in which the permeability has been enhanced by the relaxation of the strata overlying the reactor for the purposes of CO2 sequestration.
Data from: Phylogeny inference under time-decaying migration and varying information content
Creators: name: Shaik, Zaynab
name: Bergh, Nicola
name: Verboom, George
name: Oxelman, Bengt
Publisher: name: Zenodo
Year: 2023
Subjects: DENIM
StarBeast3
MCcoal
Gene flow
isolation-with-migration
multispecies coalescent

description: Postspeciation gene flow is widespread across the Tree of Life but is ignored as a cause of gene tree discordance under the standard multispecies coalescent. Where interspecific migration has occurred but is not modelled explicitly, effective population sizes, divergence times and topology can be seriously misestimated. Isolation-with-migration and multispecies coalescent-with-introgression models explicitly model migration but include additional parameters that limit their computational viability with even moderately sized molecular data sets. Here we simulate the evolution of sequences which vary in molecular information content under the coalescent while allowing continuous, tree-wide gene flow/migration between contemporaneous branches, the rate of which decreases with time since divergence. Using simulated sequences, we evaluate the performance of DENIM under rapidly to gradually time-decaying migration and benchmark its performance against the standard MSC method StarBeast3. DENIM consistently outperforms StarBeast3, both in phylogenetic accuracy and computational performance per core. Rapidly decaying migration is associated with improved topology and divergence time estimates under both DENIM and StarBeast3. While species tree estimation accuracy is not improved by increasing the number of loci from 30 to 60 under either method, model convergence is slowed considerably. By contrast, increasing sequence length to 10,000 bp has no clear effect on convergence rates, but shows a tendency towards increased accuracy in DENIM. We apply DENIM and StarBeast3 with a 36-locus empirical bat data set and recover species trees identical in topology to those obtained with 12,931 loci. Our work demonstrates that DENIM can deliver accurate phylogenetic estimates in the presence of both deep coalescence and empirically realistic migration patterns using as few as 30 loci with single-core runtimes of 2-3 days.
Can grain growth explain transition disks?
Creators: name: Birnstiel, T.
name: Andrews, S. M.
name: Ercolano, B.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Aims: Grain growth has been suggested as one possible explanation for the diminished dust optical depths in the inner regions of protoplanetary "transition" disks. In this work, we directly test this hypothesis in the context of current models of grain growth and transport. Methods: A set of dust evolution models with different disk shapes, masses, turbulence parameters, and drift efficiencies is combined with radiative transfer calculations in order to derive theoretical spectral energy distributions (SEDs) and images. Results: We find that grain growth and transport effects can indeed produce dips in the infrared SED, as typically found in observations of transition disks. Our models achieve the necessary reduction of mass in small dust by producing larger grains, yet not large enough to be fragmenting efficiently. However, this population of large grains is still detectable at millimeter wavelengths. Even if perfect sticking is assumed and radial drift is neglected, a large population of dust grains is left behind because the time scales on which they are swept up by the larger grains are too long. This mechanism thus fails to reproduce the large emission cavities observed in recent millimeter-wave interferometric images of accreting transition disks.
description: 11 pages, 5 figures, accepted to A&A
GNSS Signal Acquisition in The Presence of Narrowband Interference
Creators: name: Abdizadeh, Mohammad
Publisher: name: Graduate Studies
Year: 2013
Subjects: subject: Statistics
subject: FOS: Mathematics
subject: System Science
subject: Operations Research
subject: GNSS, Signal detection, Bit error rate

description: GNSS system vulnerability to interference is a major concern for civil applications particularly for either weak signal environment or consumer-grade receivers. This thesis provides a comprehensive analysis of the quantization and acquisition loss incurred in a conventional GNSS receiver in the presence of CW interference. It also proposes some low complexity solutions to improve the receiver performance in terms of quantization and acquisition metrics. This work contributes to the field of interference resilience consumer-grade GNSS receiver in three different ways. First, a general framework for quantization loss in a low resolution GNSS receiver is developed. Simulation results show that traditional techniques used to estimate C/N0 are unreliable when interference is present. To avoid this problem, the BER metric is employed in this work. Afterwards, it is shown that in this case, there is an optimum configuration in terms of BER and detection probability performance for a quantization process in which the AGC is allowed to dynamically adjust the gain applied to the input signal. Second, an LMS-based adaptive FIR notch filter is proposed and developed to adaptively detect, locate and reject the narrowband interference signal with negligible side effects on desired GNSS signal. Next, this NF is modified to have linear phase response in order to eliminate the bias and distortion on pseudorange measurements. Compared to IIR notch filters, an FIR notch filter is always stable and induces less numerical errors into the filtered signal. Third, the problem of GNSS signal acquisition using a consumer-grade receiver is investigated. After proposing a general framework for cell level and system level signal acquisition of a GNSS receiver, a detailed model of the impact of interference signals on the CAF of a GNSS signal is presented, and is employed in the development of novel acquisition strategies. These new strategies are examined under a selection of operating scenarios including: acquisition in the presence of interference when the receiver has some, or no a priori information regarding the interference. It is shown that, by employing these new schemes, a receiver can operate under a JNR 20 dB higher than when using traditional schemes.
PECULIARITIES OF UZBEKISTAN'S FOREIGN POLICY IN THE CENTRAL ASIAN REGION
Creators: name: Islomova Yulduz Ilkhom qizi Tashkent State University of Oriental Studies, 1st year master's degree in "International Relations and World Politics"
Publisher: name: Zenodo
Year: 2023

description: It is known that Uzbekistan is a country of strategic importance in Central Asia. At the same time, the foreign political and diplomatic relations of our country with Asian and European countries help to further strengthen the political position of Uzbekistan. On the other hand, the foreign policy of Uzbekistan under the leadership of President Shavkat Mirziyoyev experienced significant changes, in foreign policy more emphasis was placed on the policy of active cooperation and constructive diplomacy. -2030" project "We can see that a new political system is being formed, moving from the strategy of actions to the direction of development strategy. The main goals of this reform program are to establish stronger relations with the Central Asian neighbors of Uzbekistan, to jointly solve regional problems and to contribute to a more harmonious and prosperous Central Asia. In addition, the influence of our country in the region and on the world scale has increased, the world has increased confidence in New Uzbekistan and the desire to establish political and economic relations with our country, the policy of "good neighborliness" is being carried out in relation to neighboring countries, trade and the rapid development of cultural and humanitarian relations is a clear proof that the "spirit of Central Asia" has appeared in world political science.
 
Keywords: "Global Uzbekistan", strategy, "Spirit of Central Asia", international policy, Eurasian economic policy, diversified economy, SCO, OSCE, cyber security, CIS, landscape, Mazari Sharif, Peshovar, economic corridor.
Tartaric acid in red wine as one of the key factors to induce superconductivity in FeTe0.8S0.2
Creators: name: Deguchi, Keita
name: Okuda, Tohru
name: Kawasaki, Yasuna
name: Hara, Hiroshi
name: Demura, Satoshi
name: Watanabe, Tohru
name: Okazaki, Hiroyuki
name: Ozaki, Toshinori
name: Yamaguchi, Takahide
name: Takeya, Hiroyuki
name: Saito, Fumie
name: Hisamoto, Masashi
name: Takano, Yoshihiko
Publisher: name: arXiv
Year: 2012
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: The red wine dependence of superconductivity in FeTe0.8S0.2 was investigated. Samples with a higher shielding volume fraction had a tendency to show a higher concentration of tartaric acid in red wine. We found the tartaric acid is one of the key factors to induce superconductivity in FeTe0.8S0.2.
description: 9 pages, 4 figures
Turkish Noun-Noun Compounds: A Process-Based Paradigmatic Account
Creators: name: Kunduraci, Aysun
Publisher: name: Graduate Studies
Year: 2013
Subjects: subject: Linguistics
subject: FOS: Languages and literature
subject: morphology
subject: Turkish
subject: Compounding
subject: Paradigm Structure
subject: Possessedness
subject: Semantics

description: This study concerns word-formation in Turkish within the scope of theoretical morphology. I propose a paradigmatic analysis of Turkish Noun-Noun compounding and subsequent derivation within a process-based approach to morphology. I propose that Noun-Noun compounds (NNCs) such as kar ışıltı-sı (snow brightness-sI) ‘brightness of snow’ are produced by the morphological component, which is separate from both lexicon and syntax, and describe the nature of morphological operations in Turkish. This involves accounting for the semantic combination and the structure of NNCs, including the presence of the compound marker underlined above. I propose that the compound marker appears in order to create a lexeme from an N-N stem, which signals that a word-formation process has taken place. This makes -sI a derivational suffix in NNCs. I also propose that the compound marker is in a slot competition with certain derivational suffixes on the basis of non-permitted sequences in derivations involving compounding, e.g. kar tane(*-si)-li(*-si) (snow flake-(*-sI)-lI(*-sI)) ‘with snow-flake’. Namely, the compound marker and certain derivational suffixes are involved in a paradigm structure of word-formation. The proposed paradigm structure highlights the importance of paradigmatic selection in word-formation and accounts for permitted and non-permitted sequences. I also propose that the semantic rule responsible for the associative semantics of NNCs maps onto the compounding of the two nouns rather than -sI suffixation, which follows it. I further propose that the same form rule suffixing -sI also applies in possessive constructions (PCs), e.g. kar-ın ışıltı-sı (snow-GEN brightness-sI) ‘the brightness of (the) snow’. This accounts for why the same formal element appears in two distinct structures and why the sequence *-sI-sI is not allowed. Unlike the compound marker, the function of -sI in PCs is to mark the possessum: -sI in PCs is inflectional. A process-based approach to morphology, which assumes the separation of form and meaning, and treats affixes as rule elements, can easily deal with such cases. Further, I claim that -sI in PCs does not mark (3rd) Person but marks only the value ‘possessed’ of the grammatical category Possessedness in Turkish: it distinguishes possessed vs. non-possessed entities rather than 3rd vs. 1st/2nd Persons.
Deconstructing classical water models at interfaces and in bulk
Creators: name: Remsing, Richard C.
name: Rodgers, Jocelyn M.
name: Weeks, John D.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Using concepts from perturbation and local molecular field theories of liquids we divide the potential of the SPC/E water model into short and long ranged parts. The short ranged parts define a minimal reference network model that captures very well the structure of the local hydrogen bond network in bulk water while ignoring effects of the remaining long ranged interactions. This deconstruction can provide insight into the different roles that the local hydrogen bond network, dispersion forces, and long ranged dipolar interactions play in determining a variety of properties of SPC/E and related classical models of water. Here we focus on the anomalous behavior of the internal pressure and the temperature dependence of the density of bulk water. We further utilize these short ranged models along with local molecular field theory to quantify the influence of these interactions on the structure of hydrophobic interfaces and the crossover from small to large scale hydration behavior. The implications of our findings for theories of hydrophobicity and possible refinements of classical water models are also discussed.
Nonlinear elasticity, fluid flow and remodelling in biological tissues
Creators: name: Tomic, Aleksandar
Publisher: name: Graduate Studies
Year: 2012
Subjects: subject: Applied Mechanics
subject: nonlinear elasticity
subject: permeability
subject: porous material
subject: fibre-reinforced
subject: Large deformation
subject: remodelling
subject: Finite Element Method

description: Articular cartilage is a soft tissue with depth-dependent structure and composition that covers the ends of bones in diarthrodial joints. It transmits loads between bones and minimizes joint wear. The purpose of this work was to implement a large deformation nonlinear model for biological tissues with statistically oriented reinforcing fibres, using a biphasic formulation to model global articular cartilage behaviour. The implemented model takes into account the effect of the depth-dependent variation in the collagen fibre orientation and the influence of the collagen fibres on the overall permeability of the tissue. This model was implemented using Finite Element software to determine the depth-dependent deformation of articular cartilage. In addition, a separate investigation was conducted to determine the remodelling of the fibres in statistically oriented fibre reinforced materials as a response to an externally applied loading, using an arterial sample.
ДЕКРИМИНАЛИЗАЦИЯ – ЖИНОЯТ ҚОНУНИНИ ЛИБЕРАЛЛАШТИРИШНИНГ БИР КЎРИНИШИ СИФАТИДА
Creators: name: Шодмонов, Саркор
Publisher: name: Zenodo
Year: 2023

description: Мазкур мақолада Ўзбекистон Республикаси Жиноят кодексида бугунги кун шароитида ўз долзарблигини йўқотган айрим нормаларни жиноят қонунчилиги доирасидан декриминализация қилиш масалалари атрофлича муҳокама қилиниб, уларни декриминализация қилиш таклифи илграри сурилган. Шунингдек, муаллиф ушбу нормаларни маъмурий жавобгарлик доирасида қўллаш лозимлигини ривожланган мамлакатлар тажрибасида қиёсий ҳуқуқий таҳлил қилган.
Testing a Predictive Theoretical Model for the Mass Loss Rates of Cool Stars
Creators: name: Cranmer, Steven R.
name: Saar, Steven H.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The basic mechanisms responsible for producing winds from cool, late-type stars are still largely unknown. We take inspiration from recent progress in understanding solar wind acceleration to develop a physically motivated model of the time-steady mass loss rates of cool main-sequence stars and evolved giants. This model follows the energy flux of magnetohydrodynamic turbulence from a subsurface convection zone to its eventual dissipation and escape through open magnetic flux tubes. We show how Alfven waves and turbulence can produce winds in either a hot corona or a cool extended chromosphere, and we specify the conditions that determine whether or not coronal heating occurs. These models do not utilize arbitrary normalization factors, but instead predict the mass loss rate directly from a star's fundamental properties. We take account of stellar magnetic activity by extending standard age-activity-rotation indicators to include the evolution of the filling factor of strong photospheric magnetic fields. We compared the predicted mass loss rates with observed values for 47 stars and found significantly better agreement than was obtained from the popular scaling laws of Reimers, Schroeder, and Cuntz. The algorithm used to compute cool-star mass loss rates is provided as a self-contained and efficient computer code. We anticipate that the results from this kind of model can be incorporated straightforwardly into stellar evolution calculations and population synthesis techniques.
description: 23 pages (emulateapj style), 14 figures, ApJ, in press. A brief IDL subroutine that implements the model described in this paper will be distributed as "online-only material," and this code is also available at http://www.cfa.harvard.edu/~scranmer/cranmer_data.html
Dark Matter Mini-halo around the Compact Objects: the Formation, Evolution and Possible Contribution to the Cosmic Ray Electrons/Positrons
Creators: name: Yang, Rui-Zhi
name: Fan, Yi-Zhong
name: Waldman, Roni
name: Chang, Jin
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Dark matter particles may be captured by a star and then thermalized in the star's core. At the end of its life a massive star collapses suddenly and a compact object is formed. The dark matter particles redistribute accordingly. In the inelastic dark matter model, an extended dense dark matter mini-halo surrounding the neutron star may be formed. Such mini-halos may be common in the Galaxy. The electron/positron flux resulting in the annihilation of dark matter particles, however, is unable to give rise to observable signal unless a nascent mini-halo is within a distance \sim a few 0.1 pc from the Earth.
description: 12 pages, 4 figures, Accepted for publication by JCAP
Application of Field Performance Data in Developing Simple Analytical Models to Predict the Performance of Steam Assisted Gravity Drainage
Creators: name: Chan, Richard
Publisher: name: Graduate Studies
Year: 2013
Subjects: subject: Petroleum
subject: Steam Assisted Gravity Drainage
subject: SAGD
subject: Analytical Model
subject: 4D Seismic
subject: Forecast

description: A simple analytical model is developed in this paper to predict the performance of steam assisted gravity drainage (SAGD) operations. The oil drainage portion of the model is based on the work of Butler et al. (1981, 1998) to describe individual phases of SAGD operation. The steam consumption portion of the model builds on the work of various authors which include Reis (1992), Edmunds et al. (2007) and Miura et al. (2010), in which the various components of heat consumption within the reservoir are considered to determine steam injection requirements. This model extends existing models presented in literature, and accurately parameterizes model inputs using lab measured data and field performance data (including 4D seismic). The model is validated with over 10 years of field performance data, which previously has not been possible over such a long time frame owing to the fact that SAGD is a relatively new technology.
Mitochondria: Bioenergetics and Predictive Therapeutics Using Vibrational Spectroscopy
Creators: name: Solocinski, Jason
Publisher: name: My University
Year: 2021
Subjects: subject: Vibrational spectroscopy
subject: Raman spectroscopy
subject: Microspectroscopy
subject: Metabolism
subject: Metabolites
subject: Mitochondria
subject: Extracellular flux analysis
subject: Biomedical Engineering
subject: FOS: Medical engineering

description: Biomedical research comprises one of the most important and well-funded areas in all of scientific research. Technological innovation is a relatively small component of all research overall, but the applications are of immense benefit. Incorporation of already existing technologies from other areas of research directly into a biomedical setting is a simple way to leverage human innovation into the highest applicability. Vibrational spectroscopy is one such technology which, while steadily seeing more and more use in biomedical imaging, is still underutilized. Such advanced microspectroscopic techniques can leverage their ability to analyze global information in a cellular system to higher throughput and increased efficiencies. Metabolism is a key global system for every cell type and organism. Energy production, metabolic pathway augmentation, metabolite analysis, and appraisal of overall metabolic poise are several ways in which characterization of metabolism can be used analytically. Each of these can provide valuable insights into cellular systems and associated conditions, namely illness and disease. Using Raman spectroscopy to characterize metabolism has led to several interesting results. First, analysis of drug candidacy has shown a novel mode for drug testing. Effectively evaluating cellular health based on several different techniques shows level compatibility across the techniques employed. Localized spectroscopic analysis provides further evidence for mitochondrial protection conferral. In a similar vein of research, targeted analysis of desiccation tolerant proteins, localized to mitochondria, likewise showed a protective mechanism. Finally, an analysis of substrate change directly on metabolism was carefully evaluated, with an outcome of visualizing effects of varying metabolic pathways upon overall global cellular metabolism. These studies provide a strong platform for spectrometabolic evaluation to be considered for a variety of advanced characterization techniques. Coupling this method with other emerging technologies has the potential to shift the standards for metabolic evaluation.
Knowledge discovery from large-scale biological networks and their relationships.
Creators: name: Zhang, Xi
Publisher: name: University of British Columbia
Year: 2010

description: The ultimate aim of postgenomic biomedical research is to understand mechanisms of cellular systems in a systematical way. It is therefore necessary to examine various biomolecular networks and to investigate how the interactions between biomolecules determine biological functions within cellular systems. Rapid advancement in high-throughput techniques provides us with increasing amounts of large-scale datasets that could be transformed into biomolecular networks. Analyzing and integrating these biomolecular networks have become major challenges. I approached these challenges by developing novel methods to extract new knowledge from various types of biomolecular networks. Protein-protein interactions and domain-domain interactions are extremely important in a wide range of biological functions. However, the interaction data are incomplete and inaccurate due to experimental limitations. Therefore, I developed a novel algorithm to predict interactions between membrane proteins in yeast based on the protein interaction network and the domain interaction network. In addition, I also developed a novel algorithm, a gram-based interaction analysis tool (GAIA), to identify interacting domains by integrating the protein primary sequences, the domain annotations and interactions and the structural annotations of proteins. Biological assessment against several metrics indicated that both algorithms were capable of satisfactory performance, facilitating the elucidation of cell interactome. Predicting biological pathways is one of major challenges in systems biology. I proposed a novel integrated approach, called Pandora, which used network topology to predict biological pathways by integrating four types of biological evidence (protein-protein interactions, genetic interactions, domain-domain interactions, and semantic similarity of GO terms). I demonstrated that Pandora achieved better performance compared to other predictive approaches, allowing the reconstruction of biological pathways and the delineation of cellular machinery in a systematic view. Finally, I focused on investigating biological network perturbations in diseases. I developed a novel algorithm to capture highly disturbed sub-networks in the human interactome as the signatures linked to cancer outcomes. This method was applied to breast cancer and yielded improved predictive performance, providing the possibility to predict the outcome of cancers based on “network-based gene signatures”. These methods and tools contributed to the analysis and understanding of a wide variety of biological networks and the relationships between them.
Critical configurations of planar robot arms
Creators: name: Khimshiashvili, G.
name: Panina, G.
name: Siersma, D.
name: Zhukova, A.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 52R70, 52B99

description: It is known that a closed polygon P is a critical point of the oriented area function if and only if P is a cyclic polygon, that is, $P$ can be inscribed in a circle. Moreover, there is a short formula for the Morse index. Going further in this direction, we extend these results to the case of open polygonal chains, or robot arms. We introduce the notion of the oriented area for an open polygonal chain, prove that critical points are exactly the cyclic configurations with antipodal endpoints and derive a formula for the Morse index of a critical configuration.
Characterizing the pro-inflammatory cytokine response by dendritic cells upon exposure to PrP proteins
Creators: name: Ma, Roger
Publisher: name: Graduate Studies
Year: 2013
Subjects: subject: Cell
subject: Physiology
subject: FOS: Biological sciences
subject: Veterinary Science
subject: Prion
subject: Dendritic Cell
subject: Cytokine
subject: Prion pathogenesis
subject: PrP
subject: immune
subject: BMDC
subject: TNF
subject: IL-12

description: Dendritic cell (DC) interaction with infectious prions (PrPSc) represents an important part of prion pathogenesis. Previous studies have shown that DCs are likely among the first immune cells to interact with PrPSc after oral exposure. This study looks at the initial exposure of PrPSc on DC activation by measuring TNFα and IL-12 production. There was no significant production of TNFα or IL-12 by bone marrow derived DCs (BMDC) after exposure to PrPSc infected brain homogenate, however, BMDCs had lower capacity to produce IL-12 after secondary stimulation with LPS. Semi-purified PrPSc also did not activate BMDCs, however, the recombinant MoPrP 23-231 and MoPrP 90-231 elicited TNFα and IL-12 production. These results may not be surprising since PrPSc closely resembles cellular PrPC and therefore, DCs recognized PrP in brain homogenates as self-antigens. However, MoPrP 23-231 and MoPrP 90-231 were recognized as foreign antigens since the proteins were produced in bacteria.
title: Опыт строительства первых автомагистралей в Ханты-Мансийском округе в 1960-е гг.
title: Construction Experience of the First Motorways in the Khanty-Mansi Okrug in the 1960s
Creators: name: Веселов, Севостьян Игоревич
Publisher: name: Издательский центр СурГУ
Year: 2019

description: В статье представлен анализ строительства сети ведомственных автодорог на пионерном этапе нефтегазового освоения Западной Сибири. Акцентируется внимание на опыте сооружения автодорог для предприятий нефтегазовой промышленности, связанном с формированием территориально-производственного комплекса. Отмечается, что сдерживающим фактором строительства первых автомагистралей являлась слабая материально-техническая база.
description: The article presents an analysis of the construction of a network of departmental vehicle roads at the early stage of oil and gas development in Western Siberia. Attention is focused on the experience of construction of roads for the oil and gas industry, associated with the formation of territorial production complex. It is noted that the limiting factor in the construction of the first motorways was a weak material and technical base.
Комбинационная способность в адаптивной селекции сахарной свёклы
Creators: name: М.А. Богомолов
name: Т.В. Вострикова
Publisher: name: Сахар
Year: 2023
Subjects: сахарная свёкла
гибридизация
адаптивная способность
комбинационная способность
засухоустойчивость.
sugar beet
hybridization
adaptive ability
combining ability
drought resistance.

description: Проанализирована адаптивная и комбинационная способность линий и гибридных комбинаций сахарной свёклы по продуктивным признакам. В результате исследования выделены сростноплодные опылители урожайного (14044) и урожайно-сахаристого направления (15465, 15676) с высокой комбинационной и адаптивной способностью. Отмечен сростноплодный опылитель сахаристого направления (15202) и раздельноплодная мужскостерильная линия (2093) с признаками засухоустойчивости.
description: The adaptive and combinative ability of sugar beet lines and hybrid combinations according to productive traits has been analyzed. As a result of the study, fused pollinators of fruitful (14044) and fruitful-sugar type (15465, 15676) with high combining and adaptive ability were identified. A fused pollinator of the sugary type (15202) and a dioecious male-sterile line (2093) with signs of drought resistance were noted.