title: ÐÐ¾Ð·ÑÐ°ÑÑÐ½ÑÐµ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ ÑÐ¾Ð´ÐµÑÐ¶Ð°Ð½Ð¸Ñ Ð±Ð¸Ð¾Ð³ÐµÐ½Ð½ÑÑ Ð°Ð¼Ð¸Ð½Ð¾Ð² Ð² Ð³Ð¸Ð¿Ð¿Ð¾ÐºÐ°Ð¼Ð¿Ðµ ÑÐ°Ð¼Ð¾Ðº ÐºÑÑÑ Ð² Ð½Ð¾ÑÐ¼Ðµ Ð¸ Ð¿ÑÐ¸ Ð¼ÐµÑÐ¸Ð¾Ð½Ð¸Ð½Ð¾Ð²Ð¾Ð¹ Ð½Ð°Ð³ÑÑÐ·ÐºÐµ
title: Ð¼Ð°Ð³Ð¸ÑÑÐµÑÑÐºÐ°Ñ Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ñ
titleType: Subtitle
Creators: name: Ð§ÐµÑÐ½Ð¾ÑÑÐ°Ð½, ÐÑÐµÐ½Ð¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2016
Subjects: ÐÐ¼Ð¸Ð½Ñ
ÐÐµÐ¹ÑÐ¾Ð½Ñ
Ð³Ð¾Ð¼Ð¾ÑÐ¸ÑÑÐµÐ¸Ð½
Ð³Ð¸Ð¿Ð¿Ð¾ÐºÐ°Ð¼Ð¿
Ð½ÐµÐ¹ÑÐ¾ÑÐ¾ÐºÑÐ¸ÑÐµÑÐºÐ¸Ð¹ ÑÑÑÐµÐºÑ
homocysteine
hippocampus
neurotoxic effect

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description: In work was used analyzes the changes of biogenic amines in the hippocampus of female rats in the age aspect when exposed to an experimental model of hyperhomocysteinemia. With the help of a detailed study of the homocysteine level in blood and tissues of the brain and behavioral research, it proved the efficiency of the proposed model hyperhomocysteinemia with chronic methionine load to examine possible violations of catecholaminergic systems in the hippocampus of animals. In the study we used the following methods: identification of concentrations of biogenic amines by high performance liquid chromatography, quantitative determination of homocysteine by enzyme-linked immunosorbent assay, behavioral tests and statistical processing program STASISTICA 10.0. It is shown that methionine load leads to the development of female rats hyperhomocysteinemia. Thus homocysteine showed accumulation in the blood of animals hippocampus and hypothalamus. Disturbances in the behavior of rats undergoing chronic methionine load, characterized by a decrease in the recognition of new objects and the violation of spatial orientation. It is showing a decline of basic investigated biogenic amines: norepinephrine (NE), serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) in the structures of the hippocampus and the hypothalamus with age, and the impact of homocysteine to reduce NE, 5-HIAA, and the ratio of 5-HIAA / 5-HT in young animals hippocampus.