cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Combining QSAR techniques, molecular docking, and molecular dynamics simulations to explore anti-tumor inhibitors targeting Focal Adhesion Kinase
Creators: name: Liu, Yuan
name: Tong, Jian-Bo
name: Gao, Peng
name: Fan, Xuan-lu
name: Xiao, Xue-chun
name: Xing, Yi-chaung
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Molecular Biology
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Focal Adhesion Kinase (FAK) is an important target for tumor therapy and is closely related to tumor cell genesis and progression. In this paper, we selected 46 FAK inhibitors with anticancer activity in the pyrrolo pyrimidine backbone to establish 3D/2D-QSAR models to explore the relationship between inhibitory activity and molecular structure. We have established two ideal models, namely, the Topomer CoMFA model (q2= 0.715, r2= 0.984) and the Holographic Quantitative Structure-Activity Relationship (HQSAR) model (q2= 0.707, r2= 0.899). Both models demonstrate excellent external prediction capabilities.Based on the QSAR results, we designed 20 structurally modified novel compounds, which were subjected to molecular docking and molecular dynamics studies, and the results showed that the new compounds formed many robust interactions with residues within the active pocket and could maintain stable binding to the receptor proteins. This study not only provides a powerful screening tool for designing novel FAK inhibitors, but also presents a series of novel FAK inhibitors with high micromolar activity that can be used for further characterization. It provides a reference for addressing the shortcomings of drug metabolism and drug resistance of traditional FAK inhibitors, as well as the development of novel clinically applicable FAK inhibitors.
Insufficient Incentives for Investment in Electricity Generation
Creators: name: Neuhoff, Karsten
name: De Vries, Laurens
Publisher: name: Faculty of Economics
Year: 2004
Subjects: subject: investment, electricity, consumer utility, long-term contracts

description: In theory, competitive electricity markets can provide incentives for efficient investment in generating capacity. We show that if consumers and investors are risk averse, investment is efficient only if investors in generating capacity can sign long-term contracts with consumers. Otherwise the uncovered price risk increases financing costs, reduces equilibrium investment levels, distorts technology choice towards less capital-intensive generation and reduces consumer utility. We observe insufficient levels of long-term contracts in existing markets, possibly because retail companies are not credible counter-parties if their final customer can switch easily. With consumer franchise, retailers can sign long-term contracts, but this solution comes at the expense of the idea of retail competition. Alternative capacity mechanisms to stimulate investment are discussed.
Exchange Rate Monitoring Bands: Theory and Policy
Creators: name: Corrado, Luisa
name: Miller, Marcus
name: Zhang, Lei
Publisher: name: Faculty of Economics
Year: 2004
Subjects: subject: Classification-JEL: D52, F31, G12
subject: monitoring band, non-linear mean-reversion, near random walk dynamics

description: Recent empirical research by Mark Taylor and coauthors has found evidence of hybrid dynamics for real exchange rates. While there is a random walk near equilibrium, for real exchange rates some distance from equilibrium there is mean-reversion which increases with the degree of misalignment. An interesting question is whether this nonlinear mean-reversion might be policy-induced. John Williamson (1998), for example, has proposed a �monitoring band� in which there is no intervention near equilibrium but there is substantial intervention triggered by exchange rate deviations outside a preset band. In this paper we develop a theoretical model of such a monitoring band to see whether it can generate patterns of nonlinear mean-reversion akin to those reported in empirical research.
The Semiclassical Description of Tunneling in Scattering with Multiple Degrees of Freedom
Creators: name: Bonini, G. F.
name: Cohen, A. G.
name: Rebbi, C.
name: Rubakov, V. A.
Publisher: name: arXiv
Year: 1999
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We describe a computational investigation of tunneling at finite energy in a weakly coupled quantum mechanical system with two degrees of freedom. We compare a full quantum mechanical analysis to the results obtained by making use of a semiclassical technique developed in the context of instanton-like transitions in quantum field theory. This latter technique is based on an analytic continuation of the degrees of freedom into a complex phase space, and the simultaneous analytic continuation of the equations of motion into the complex time plane.
description: 33 pages, 8 figures, latex with graphicx
Identifying and Interpreting Convergence Clusters Across Europe
Creators: name: Corrado, Luisa
name: Martin, Ron
name: Weeks, Melvyn
Publisher: name: Faculty of Economics
Year: 2004
Subjects: subject: Classification-JEL: C51, R11, R15
subject: regional convergence, pairwise regional comparison, new economics geography

description: In this paper we examine the spatial and temporal distribution of per capita income across Europe. We base our analysis on a cluster methodology which allows for an endogenous selection of regional clusters using a multivariate test for stationarity where the number and composition of clusters are determined by the application of pairwise tests of regional contrasts. To circumvent the problem of how to interpret the composition of resulting convergence clusters we construct a number of testable hypotheses based upon orderings consistent with the findings of recent studies on regional growth and convergence. We do this using a set of geographical, socio-demographic and political indicators measuring contiguity and institutional similarity, accessibility, specialisation, region specific levels of agglomeration and regional classification according to the European Union Structural Fund objectives. One of the contributions of our study is a method which facilitates the interpretation of the cluster outcomes on the basis of the factors identified above. Unlike previous studies, we present our results using a geographic representation of regions across Europe.
Collective Dynamics of Solitons and Inequivalent Quantizations
Creators: name: Garrahan, Juan Pedro
name: Kruczenski, Martin
Publisher: name: arXiv
Year: 1997
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The collective dynamics of solitons with a coset space G/H as moduli space is studied. It is shown that the collective band for a vibrational state is given by the inequivalent coset space quantization corresponding to the representation of H carried by the vibration.
description: 6 pages, revtex
Hysteresis of economic networks in an XY model
Creators: name: Hosseiny, Ali
name: Absalan, Mohammadreza
name: Sherafati, Mohammad
name: Gallegati, Mauro
Publisher: name: arXiv
Year: 2018
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: General Economics (econ.GN)
subject: FOS: Physical sciences
subject: FOS: Economics and business

description: Many-body systems can have multiple equilibria. Though the energy of equilibria might be the same, still systems may resist to switch from an unfavored equilibrium to a favored one. In this paper we investigate occurrence of such phenomenon in economic networks. In times of crisis when governments intend to stimulate economy, a relevant question is on the proper size of stimulus bill. To address the answer, we emphasize the role of hysteresis in economic networks. In times of crises, firms and corporations cut their productions; now since their level of activity is correlated, metastable features in the network become prominent. This means that economic networks resist against the recovery actions. To measure the size of resistance in the network against recovery, we deploy the XY model. Though theoretically the XY model has no hysteresis, when it comes to the kinetic behavior in the deterministic regimes, we observe a dynamic hysteresis. We find that to overcome the hysteresis of the network, a minimum size of stimulation is needed for success. Our simulations show that as long as the networks are Watts-Strogatz, such minimum is independent of the characteristics of the networks.
description: To be appeared in Physica A: Statistical Mechanics and its Applications
Tenedos O. Pickard-Cambridge 1897
Creators: name: Martínez, Leonel
name: Brescovit, Antonio D.
name: Martínez, Carlos Prieto
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Zodariidae
Tenedos

description: Tenedos O. Pickard-Cambridge, 1897
 Tenedos O. Pickard-Cambridge, 1897: 6, type species: Tenedos lautus O. Pickard-Cambridge, 1897: 226; Jocqué 1991: 93; Jocqué & Baert 1996: 309; Jocqué & Baert 2002: 80.
 Tijuca Mello-Leit „o, 1925: 461 (preoccupied by Tijuca Férussac, 1829 in Aves), type species: Tijuca eduardoi Mello-Leit „o, 1925: 462.
 Naibena Chamberlin, 1925: 214, type species: Naibena barrona Chamberlin, 1925: 214; Jocqué 1991: 93 (Synonymy).
 Tijucaia Mello-Leit „o, 1940: 33 (nomem novum for Tijuca); Jocqué 1991: 93 (Synonymy).
description: Published as part of Martínez, Leonel, Brescovit, Antonio D. & Martínez, Carlos Prieto, 2023, Revealing the diversity of ant-eating spiders in Colombia II: morphology, distribution, and taxonomy of the trilobatus group of the genus Tenedos O. Pickard-Cambridge, 1897 (Araneae: Zodariidae), pp. 1-66 in Zootaxa 5328 (1) on page 7, DOI: 10.11646/zootaxa.5328.1.1, http://zenodo.org/record/8243895
Additional file 6: of Biological clock function is linked to proactive and reactive personality types
Creators: name: Tudorache, Christian
name: Slabbekoorn, Hans
name: Robbers, Yuri
name: Hin, Eline
name: Meijer, Johanna
name: Spaink, Herman
name: Schaaf, Marcel
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Figure S5. Correlation between diurnal pattern of locomotor activity and emergence rank under normal light/dark (LD) regime and under constant (LL) light regime. A) The strength of the diurnal rhythm (dimensionless) under LD plotted against emergence rank 1–10, showing a significant negative correlation. B) Amplitude of locomotion activity in units of swimming velocity (V, mm s−1) under LD plotted against emergence rank 1–10 showing a significant negative correlation. C) Area under the curve of locomotion activity (AUC, dimensionless) under LD plotted against emergence rank 1–10, showing a significant negative correlation. D) Maximum swimming velocity (Vmax, mm s−1) as average over three days under LD plotted against emergence rank 1–10 showing no significant correlation. E) Rhythm strength (dimensionless) under LL plotted against emergence rank 1–10, showing no significant correlation. F) Amplitude of locomotion activity in units of swimming velocity (V, mm s−1) under LL plotted against emergence rank 1–10 showing no significant correlation. G) Area under the curve of locomotion activity (AUC, dimensionless) under LL plotted against emergence rank 1–10 with no significant correlation (Spearman rank test, significance accepted at p
Additional file 15: of Dynamics of transcriptome changes during subcutaneous preadipocyte differentiation in ducks
Creators: name: Wang, Zheng
name: Yin, Zhong-Tao
name: Zhang, Fan
name: Li, Xiao-Qin
name: Chen, Si-Rui
name: Yang, Ning
name: Porter, Tom
name: Hou, Zhuocheng
Publisher: name: figshare
Year: 2019
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Computational Biology

description: Figure S5. Design and sampling strategy of the differentiation process of duck subcutaneous preadipocyte. (PDF 1095 kb)
Exploring the hub genes and potential drugs involved in Fanconi anemia using microarray datasets and bioinformatics analysis
Creators: name: Hameed, Alaa R.
name: Ali, Sama Fakhri
name: Almanaa, Taghreed N.
name: Aljasir, Mohammad Abdullah
name: Alruwetei, Abdulmohsen M.
name: Sanami, Samira
name: Ayaz, Hassan
name: Ali, Ijaz
name: Ahmad, Faisal
name: Ahmad, Sajjad
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer

description: Fanconi anemia (FA) is a genetic disorder that occurs when certain genes responsible for repairing DNA replication and promoting homologous recombination fail to function properly. This leads to severe clinical symptoms and a wide range of cancer-related characteristics. Recent treatment approaches for FA involve hematopoietic stem cell transplantation (HSCT), which helps restore the population of stem cells. A survival study using p-values indicated that specific hub genes play a significant role in diagnosing and predicting the disease. To find potential medications that interact with the identified hub genes, researchers inferred drugs. Among hub genes, TP53 was found to be particularly promising through computational analysis. Further investigation focused on two drugs, Topiramate and Tocofersolan predicted based on drug bank database analysis. Molecular docking strategies were employed to assess the best binding pose of these drugs with TP53. Topiramate showed a binding affinity of −6.5 kcal/mol, while Tocofersolan showed −8.5 kcal/mol against the active residues within the binding pocket. Molecular dynamics (MD) simulations were conducted to observe the stability of each drug’s interaction with the TP53 protein over time. Both drugs exhibited stable confirmation with only slight changes in the loop region of the TP53 protein during the simulation intervals. Results also shows that there was a high fluctuation observed during apo-sate simulation time intervals as compared to complex system. Hence, it is suggested that the exploration of structure-based drug design holds promising results to specific target. This could potentially lead to a breakthrough in future experimental approaches for FA treatment.
Theoretical method for generating regular spatiotemporal pulsed-beam with controlled transverse-spatiotemporal dispersion
Creators: name: Li, Zhaoyang
name: Miyanaga, Noriaki
Publisher: name: arXiv
Year: 2018
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Herein we theoretically report a method that generates a transverse-spatiotemporal dispersion (T-STD), which is distinct from previous spatial, temporal, and longitudinal-spatiotemporal optics dispersions. By modulating T-STD, two not yet reported spatiotemporally structured beams (STSBs), i.e., the honeycomb beam and the picket-fence beam, can be generated in the space-time domain. The generated STSBs have novel and tunable periodic distributions. T-STD, STSB and their inner physical relationship are analyzed and introduced. We believe that this method might open a path towards new optical beams for potential applications, such as ultrafast optical fabrication and detection.
description: 6 pages, 5 figures
Search for Unstable Heavy and Excited Leptons at LEP2
Creators: name: The OPAL Collaboration
name: Abbiendi, G.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Searches for unstable neutral and charged heavy leptons, N and L+-, and for excited states of neutral and charged leptons, nu*, e*, mu*, and tau*, have been performed in e+e- collisions using data collected by the OPAL detector at LEP. The data analysed correspond to an integrated luminosity of about 58pb-1 at a centre-of-mass energy of 183GeV, and about 10pb-1 each at 161GeV and 172GeV. No evidence for new particles was found. Lower limits on the masses of unstable heavy and excited leptons are derived. From the analysis of charged-current, neutral-current, and photonic decays of singly produced excited leptons, upper limits are determined for the ratio of the coupling to the compositeness scale, f/Lambda, for masses up to the kinematic limit. For excited leptons, the limits are established independently of the relative values of the coupling constants f and f'.
description: 27 pages, 8 figures, submitted to Eur.Phys. J. C
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Cart. 188 (11 H 73), f. 0284v
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Archives départementales de la Côte-d'Or, Cart. 188 (11 H 73), f. 0284v, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Archives départementales de la Côte-d'Or, Cart. 188 (11 H 73), f. 0284v, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Algorithm unfolding for block-sparse and MMV problems with reduced training overhead
Creators: name: Hauffen, Jan Christian
name: Jung, Peter
name: Mücke, Nicole
Publisher: name: Frontiers Media SA
Year: 2023
Subjects: subject: 500 Naturwissenschaften und Mathematik::510 Mathematik::510 Mathematik
subject: unfolding
subject: compressed sensing
subject: multiple measurement vector problem
subject: deep learning
subject: block-sparsity

description: In this study, we consider algorithm unfolding for the multiple measurement vector (MMV) problem in the case where only few training samples are available. Algorithm unfolding has been shown to empirically speed-up in a data-driven way the convergence of various classical iterative algorithms, but for supervised learning, it is important to achieve this with minimal training data. For this, we consider learned block iterative shrinkage thresholding algorithm (LBISTA) under different training strategies. To approach almost data-free optimization at minimal training overhead, the number of trainable parameters for algorithm unfolding has to be substantially reduced. We therefore explicitly propose a reduced-size network architecture based on the Kronecker structure imposed by the MMV observation model and present the corresponding theory in this context. To ensure proper generalization, we then extend the analytic weight approach by Liu and Chen to LBISTA and the MMV setting. Rigorous theoretical guarantees and convergence results are stated for this case. We show that the network weights can be computed by solving an explicit equation at the reduced MMV dimensions which also admits a closed-form solution. Toward more practical problems, we then considered convolutional observation models and show that the proposed architecture and the analytical weight computation can be further simplified and thus open new directions for convolutional neural networks. Finally, we evaluate the unfolded algorithms in numerical experiments and discuss connections to other sparse recovering algorithms.
Additional file 4: of Biological clock function is linked to proactive and reactive personality types
Creators: name: Tudorache, Christian
name: Slabbekoorn, Hans
name: Robbers, Yuri
name: Hin, Eline
name: Meijer, Johanna
name: Spaink, Herman
name: Schaaf, Marcel
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Figure S3. Correlation between expression patterns of clock-related genes and emergence rank. Area under the curve (AUC) and amplitude for relative expression patterns of bmal1a (A), clock1a (B), per1a (C), cry1a (D) and cipca (E) mRNA determined with quantitative real-time PCR (qPCR) in the brain tissue of fish from the entire range of emergence ranks (1–10). AUC values show a significant negative correlation with emergence rank for bmal1a and cipca, indicating decreasing expression activity with reduced risk-taking behaviour. Similarly, amplitude values (F–J) show a significant negative correlation with emergence rank for all genes, indicating increasingly dampened rhythmicity of the expression with reduced risk-taking behaviour. Solid lines indicate significant correlations (Spearman rank test, significance accepted at p
Tuberkuloseversorgung in Deutschland unter Pandemiebedingungen – eine Online-Umfrage des DZK im Öffentlichen Gesundheitsdienst
Creators: name: Häcker, Brit
name: Otto-Knapp, Ralf
name: Bauer, Torsten
name: Breuer, Cornelia
name: Priwitzer, Martin
Publisher: name: Robert Koch-Institut
Year: 2021
Subjects: subject: Tuberkulose
subject: ÖGD
subject: Covid_19-Pandemie
subject: meldepflichtige Infektionskrankheiten
subject: Surveillance
subject: 610 Medizin und Gesundheit

description: Seit Beginn der COVID-19-Pandemie kommt es in vielen Ländern zu einem Rückgang der gemeldeten Tuberkulosefälle. In Ländern mit geringem oder mitt¬lerem Einkommen werden vor allem Einschränkungen der allgemeinen Gesundheitsversorgung als Ursache diskutiert. Kurz- wie auch mittelfristigen könnte dies zu einem Anstieg sowohl der Tuberkulose-Todesfälle als auch der -Neuerkrankungen führen. In Deutschland, wo 2020 ein Rückgang von verschiedenen meldepflichtigen Erkrankungen be-obachtet wurde, stellt sich die Frage, ob eine Überlastung des Gesundheitswesens eine Rolle in der Tuberkulosekontrolle spielt. Um eine Einschätzung aus dem Öffentlichen Gesundheits¬dienst zur derzeitigen Versorgungssituation bei der Tuberkulose zu erhalten, führte das Deutsche Zentralkomitee zur Bekämpfung der Tuberkulose einen Survey durch.
Stabilized NMSSM without Domain Walls
Creators: name: Panagiotakopoulos, C.
name: Tamvakis, K.
Publisher: name: arXiv
Year: 1998
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We reconsider the Next to Minimal Supersymmetric Standard Model (NMSSM) as a natural solution to the $μ$-problem and show that both the stability and the cosmological domain wall problems are eliminated if we impose a ${\cal {Z}}_2$ $R$-symmetry on the non-renormalizable operators.
description: 5 pages
Phytochemical composition, anti-microbial, anti-oxidant and anti-diabetic effects of Solanum elaeagnifolium Cav. leaves: in vitro and in silico assessments
Creators: name: T., Francis Xavier
name: R., Sabitha
name: K., Freeda Rose A.
name: S., Balavivekananthan
name: R., Kariyat
name: M., Ayyanar
name: S., Vijayakumar
name: S., Prabhu
name: S., Amalraj
name: K., Shine
name: M., Thiruvengadam
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biophysics
Biochemistry
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: The aim of this study was to screen the chemical components of Solanum elaeagnifolium leaves and assess their therapeutic attributes with regard to their antioxidant, antibacterial, and antidiabetic activities. The antidiabetic effects were explored to determine the α-amylase and α-glucosidase inhibitory potential of the leaf extract. To identify the active antidiabetic drugs from the extracts, the GC-MS-screened molecules were docked with diabetes-related proteins using the glide module in the Schrodinger Tool. In addition, molecular dynamics (MD) simulations were performed for 100 ns to evaluate the binding stability of the docked complex using the Desmond module. The ethyl acetate had a significant total phenolic content (TPC), with a value of 79.04 ± 0.98 mg/g GAE. The ethanol extract was tested for its minimum inhibitory concentration (MIC) for its bacteriostatic properties. It suppressed the growth of B. subtilis, E. coli, P. vulgaris, R. equi and S. epidermis at a dosage of 118.75 µg/mL. Moreover, the IC50 values of the ethanol extract were determined to be 17.78 ± 2.38 in the α-amylase and and 27.90 ± 5.02 µg/mL in α-glucosidase. The in-silico investigation revealed that cyclolaudenol achieved docking scores of −7.94 kcal/mol for α-amylase. Likewise, the α-tocopherol achieved the docking scores of −7.41 kcal/mol for glycogen phosphorylase B and −7.21 kcal/mol for phosphorylase kinase. In the MD simulations, the cyclolaudenol and α-tocopherol complexes exhibited consistently stable affinities with diabetic proteins throughout the trajectory. Based on these findings, we conclude that this plant could be a good source for the development of novel antioxidant, antibacterial, and antidiabetic agents.
MOESM1 of A machine vision platform for measuring imbibition of maize kernels: quantification of genetic effects and correlations with germination
Creators: name: Miller, Nathan
name: Stelpflug, Scott
name: Kaeppler, Shawn
name: Spalding, Edgar
Publisher: name: figshare
Year: 2018
Subjects: subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Plant Biology

description: Additional file 1. Information about inbred lines used for the seed source and diallel experiments. Table of genotypes, pedigrees, year of kernel production
Welfare Impacts of Electricity Generation Sector Reform in the Philippines
Creators: name: Toba, Natsuko
Publisher: name: Faculty of Economics
Year: 2004
Subjects: subject: Classification-JEL: O10; D61; L50; L10; L94.
subject: Electricity; Cost-benefit-analysis; Institutional change.

description: This paper reports an empirical investigation into the welfare impacts of an introduction of private sector participation into the Philippines electricity generation sector, by liberalizing the market for independent power producers (IPPs) during the power crisis of 1990-1993. This study uses a social cost and benefit analysis. The main benefits came from IPPs, who contributed to resolving the crisis, and promoted economic and social development. Consumers and investors are net gainers, while the Government lost and there was an air pollution cost. The paper concludes that the reform with private sector participation increased social welfare.
Integer ratios of consecutive alternating power sums
Creators: name: Baoulina, Ioulia N.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11B83

description: We give a characterization of all pairs $(k,n)$ of positive integers for which the ratio $$ \frac{1^k-2^k+3^k-\dots+(-1)^{n+1} n^k}{1^k-2^k+3^k-\dots+(-1)^{n}(n-1)^k} $$ of two consecutive alternating power sums is an integer.
description: 4 pages; to appear in the Amer. Math. Monthly
The Difficult Transition to Competitive Electricity Markets in the U.S.
Creators: name: Joskow, Paul
Publisher: name: Faculty of Economics
Year: 2004

description: This paper discusses the causes and consequences of state and federal initiatives to introduce wholesale and retail competition into the U.S. electricity sector from 1995. The development and performance of wholesale market institutions, the expansion of wholesale power trade, the entry of merchant generating capacity, and the financial collapse of the trading and merchant generating sector is discussed. Issues regarding the ability of evolving spot wholesale energy market institutions and market power mitigation mechanisms in the absence of some form of peak capacity obligation are discussed theoretically and evaluated empirically. The diffusion of retail competition and the performance of retail competition programs in eight states is examined empirically. The analysis leads to the overall conclusion that the development of efficient competitive wholesale and retail electricity markets continues to be a work in progress and faces many technical,
Additional file 2 of Construction and validation of a prognostic model of RNA binding proteins in clear cell renal carcinoma
Creators: name: Han, Wenkai
name: Fan, Bohao
name: Huang, Yongsheng
name: Wang, Xiongbao
name: Zhang, Zhao
name: Gu, Gangli
name: Liu, Zhao
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer

description: Additional file 2: Supplement Table 2. Results of differential expression analysis of RBPs in the TCGA database ccRCC.
Policy manifold generation for multi-task multi-objective optimization of energy flexible machining systems
Creators: name: Qinge, Xiao
name: Niu, Ben
name: Ying, Chen
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Contemporary organizations recognize the importance of lean and green production to realize ecological and economic benefits. Compared with the existing optimization methods, the multi-task multi-objective reinforcement learning (MT-MORL) offers an attractive means to address the dynamic, multi-target process-optimization problems associated with Energy-Flexible Machining (EFM). Despite the recent advances in reinforcement learning, the realization of an accurate Pareto frontier representation remains a major challenge. This article presents a generative manifold-based policy-search method to approximate the continuously distributed Pareto frontier for EFM optimization. To this end, multi-pass operations are formulated as part of a multi-policy Markov decision process, wherein the machining configurations witness dynamic changes. However, the traditional Gaussian distribution cannot accurately fit complex upper-level policies. Thus, a multi-layered generator was designed to map the high-dimensional policy manifold from a simple Gaussian distribution without performing complex calculations. Additionally, a hybrid multi-task training approach is proposed to handle the mode collapse and large task difference observed during the improvement of the generalization performance. Extensive computational testing and comparisons against existing baseline methods have been performed to demonstrate the improved Pareto frontier quality and computational efficiency of the proposed algorithm.
Synergy between human DNA ligase I and topoisomerase 1 unveils new therapeutic strategy for the management of colorectal cancer
Creators: name: Maurya, Pooja
name: Rawat, Rohit Singh
name: Gupta, Sampa
name: Krishna, Shagun
name: Siddiqi, Mohammad Imran
name: Sashidhara, Koneni V.
name: Banerjee, Dibyendu
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Medicine
Cell Biology
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Developmental Biology
Cancer
Hematology
Virology

description: DNA topoisomerase 1 (Topo 1) is a pivotal player in various DNA processes, including replication, repair, and transcription. It serves as a target for anticancer drugs like camptothecin and its derivatives (Topotecan and SN-38/Irinotecan). However, the emergence of drug resistance and the associated adverse effects, such as alopecia, anemia, dyspnea, fever, chills, and painful or difficult urination, pose significant challenges in Topo 1-targeted therapy, necessitating urgent attention. Human DNA Ligase 1 (hLig I), recognized primarily for its role in DNA replication and repair of DNA breaks, intriguingly exhibits a DNA relaxation activity akin to Topo 1. This raised the hypothesis that hLig I might compensate for Topo 1 inhibition, contributing to resistance against Topo 1 inhibitors. To explore this hypothesis, we assessed the efficacy of hLig I inhibition alone and in combination with Topo 1 in cancer cells. As anticipated, the overexpression of hLig I was observed after Topo 1 inhibition in colorectal cancer cells, affirming our hypothesis. Previously identified as an inhibitor of hLig I’s DNA relaxation activity, compound 27 (C 27), when combined with Topotecan, demonstrated a synergistic antiproliferative effect on colorectal cancer cells. Notably, cells with downregulated hLig I (via siRNA, inhibitors, or genetic manipulation) exhibited significantly heightened sensitivity to Topotecan. This observation strongly supports the concept that hLig I contribute to resistance against clinically relevant Topo 1 inhibitors in colorectal cancers. In conclusion, our findings offer evidence for the synergistic impact of combining hLig I inhibitors with Topotecan in the treatment of colorectal cancers, providing a promising strategy to overcome resistance to Topo 1 inhibitors.
Information generating, sharing and manipulating Source-Reservoir-Sink model of self-organizing dissipative structures
Creators: name: Ahmad, Shoaib
Publisher: name: arXiv
Year: 2018
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Information-theoretic description of the signal transmitter, the channel and receiver is extended to the network of self-organizing dissipative structures consisting of a source, a reservoir and a sink. The information generation by the source is subjected to controlled manipulation by the reservoir before being transmitted to the sink. The reservoir can have memory and variable capacity for information storage. The role of the reservoir in building the manipulative capacity for information storage and selective sharing is illustrated by the characteristic of asymmetric exchange between the reservoir and the sink. A box-model is used to develop the model to represent material, process and information sharing among the source, the reservoir and the sink. The model is applied to self-organizing carbon cages with the end-directed evolution of the buckyball.
description: 37 pages, 14 figures, 3 tables
Radiative corrections to the decays K_L^0->e^+e^- and K_L^0->mu^+mu^-
Creators: name: Dicus, Duane A.
name: Repko, Wayne W.
Publisher: name: arXiv
Year: 1999
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We calculate the rates and lepton (l) invariant mass distributions for decays of the form 0^{-+}->l^+l^-γ, which are important radiative corrections to the purely leptonic decays 0^{-+}->l^+l^-. Our approach uses the loop diagrams which arise by including the two photon intermediate state and we retain the imaginary parts of the loops - a radiative extension of the `unitarity bound' for the process. These results are compared which those obtained using a model in which the meson couples directly to the leptons.
description: 13 pages, 6 figures, ReVTeX
Technical efficiency in electricity generation - the impact of smallness and isolation of island economies
Creators: name: Domah, Preetum
Publisher: name: Faculty of Economics
Year: 2004
Subjects: subject: Classification-JEL: D20; L25; L94; N70
subject: Electricity; SFA; Malmquist DEA; small islands

description: Technical efficiency in electricity generation - the impact of smallness and isolation of island economies
Additional file 3 of Construction and validation of a prognostic model of RNA binding proteins in clear cell renal carcinoma
Creators: name: Han, Wenkai
name: Fan, Bohao
name: Huang, Yongshen
name: Wang, Xiongbao
name: Zhang, Zhao
name: Gu, Gangli
name: Liu, Zhao
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer

description: Additional file 3: Supplement Table 3: Number of nodes in the PPI network.
Modelling corporate tax liabilities using company accounts: a new framework
Creators: name: Ahmed, Saeed
Publisher: name: Faculty of Economics
Year: 2004
Subjects: subject: Classification-JEL: C33, E17, G32, G35, H25, H32
subject: Corporate income tax, panel data, corporate structure, financial and dividend policy, revenue estimation and forecasting, microsimulation modelling

description: This paper presents a micro-econometric approach to corporate tax modelling. Using firm level panel data of UK companies in three diverse sectors, the paper examines the impact of different variables on corporate tax liabilities of the firms. Many strong results stand out which suggest that firms reduce their tax liabilities through different channels and tax sheltering activities to maximise �after-tax� profits. The evidence shows, inter alia, that not only are trading profits and capital gains important determinants of corporation tax payments but so also are their components, such as gross profit, cost of sales, expenses, and even one-off �exceptional items� and �extraordinary items�. The results also indicate that firms� size, organisational structure, investments, and financial and dividend policies are important factors impacting on corporate tax liabilities. Moreover, different tax reliefs and allowances are strongly associated with corporation tax payments asymmetrically. The findings have implications for microsimulation modelling, financial transparency, and corporate governance.
On the Evolution of Regional Asymmetries
Creators: name: Giovannetti, Emanuele
Publisher: name: Faculty of Economics
Year: 2004
Subjects: subject: Classification-JEL: L13, R12, O31
subject: Leapfrogging, convergence, Local interaction, Technological adoption, Inta- distribution mobility

description: The paper models the evolution of regional asymmetries, and the associated intra-distribution mobility, as the outcome of adoption decisions taken by firms at different locations. The following equilibria are characterised: Persistent asymmetry where nobody adopts, Leapfrogging where low-quality firms adopt, Forging ahead where high-quality firms adopt, and Catching up where everybody adopts. The paper studies the impact of economic integration on these equilibria and the evolution of technological asymmetries as well as intra-distribution mobility. In equilibrium, the regional intra-distribution Mobility is described by fluctuations between periods of Leapfrogging, Forging ahead and Catching up.
Policy manifold generation for multi-task multi-objective optimization of energy flexible machining systems
Creators: name: Xiao, Qinge
name: Niu, Ben
name: Chen, Ying
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Contemporary organizations recognize the importance of lean and green production to realize ecological and economic benefits. Compared to the existing optimization methods, the multi-task multi-objective reinforcement learning (MT-MORL) offers an attractive means to address the dynamic, multi-target process-optimization problems associated with energy-flexible machining (EFM). Despite the recent advances in RL, the realization of an accurate Pareto frontier representation remains a major challenge. This paper presents a generative manifold-based policy-search method to approximate the continuously distributed Pareto frontier for EFM optimization. To this end, multi-pass operations are formulated as part of a multi-policy Markov decision process, wherein the machining configurations witness dynamic changes. However, the traditional Gaussian distribution cannot accurately fit complex upper-level policies. Thus, a multi-layered generator was designed to map the high-dimensional policy manifold from a simple Gaussian distribution without performing complex calculations. Additionally, a hybrid multi-task training approach is proposed to handle the mode collapse and large task difference observed during the improvement of the generalization performance. Extensive computational testing and comparisons against existing baseline methods and four meta-heuristics have been performed to demonstrate the improved Pareto frontier quality and computational efficiency of the proposed algorithm.
Modelling the Costs of Electricity Regulation: Evidence of Human Resource Constraints in Developing Countries
Creators: name: Domah, Preetum
name: Pollitt, Michael G.
name: Stern, Jon
Publisher: name: Faculty of Economics
Year: 2004
Subjects: subject: Classification-JEL: Electricity Regulation; International Comparisons; Human Resources
subject: L30; N40; O15

description: Modelling the Costs of Electricity Regulation: Evidence of Human Resource Constraints in Developing Countries
Willis metamaterial on a structured beam
Creators: name: Liu, Yongquan
name: Liang, Zixian
name: Zhu, Jian
name: Xia, Lingbo
name: Mondain-Monval, Olivier
name: Brunet, Thomas
name: Alù, Andrea
name: Li, Jensen
Publisher: name: arXiv
Year: 2018
Subjects: subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: Bianisotropy is common in electromagnetics whenever a cross-coupling between electric and magnetic responses exists. However, the analogous concept for elastic waves in solids, termed as Willis coupling, is more challenging to observe. It requires coupling between stress and velocity or momentum and strain fields, which is difficult to induce in non-negligible levels, even when using metamaterial structures. Here, we report the experimental realization of a Willis metamaterial for flexural waves. Based on a cantilever bending resonance, we demonstrate asymmetric reflection amplitudes and phases due to Willis coupling. We also show that, by introducing loss in the metamaterial, the asymmetric amplitudes can be controlled and can be used to approach an exceptional point of the non-Hermitian system, at which unidirectional zero reflection occurs. The present work extends conventional propagation theory in plates and beams to include Willis coupling, and provides new avenues to tailor flexural waves using artificial structures.
description: 21 pages, 3 figures
Transitions Between Hall Plateaus and the Dimerization Transition of a Hubbard Chain
Creators: name: Lee, Dung-Hai
name: Wang, Ziqiang
Publisher: name: arXiv
Year: 1995
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: We show that the plateau transitions in the quantum Hall effect is the same as the dimerization transition of a half-filled, one dimensional, $U(2n)$ Hubbard model at $n=0$. We address the properties of the latter by a combination of perturbative renormalization group and Monte Carlo simulations. Results on both critical and off-critical properties are presented.
description: minor changes
Test Result of Time-Of-Propagation Cherenkov Counter
Creators: name: Ohshima, Takayoshi
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: A new concept concerning Cherenkov detector for particle identification by means of measuring both the Time-of-Propagation (TOP) and horizontal emission angle ($Φ$) of Cherenkov photons is described here. Some R&D works are also reported.
description: 5 pages, 7 Figures, LaTeX
MOESM1 of Proteomic analysis of serum proteins from HIV/AIDS patients with Talaromyces marneffei infection by TMT labeling-based quantitative proteomics
Creators: name: Yahong Chen
name: Aiqiong Huang
name: Ao, Wen
name: Zhengwu Wang
name: Jinjin Yuan
name: Song, Qing
name: Dahai Wei
name: Hanhui Ye
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences
subject: 60506 Virology
subject: Computational Biology

description: Additional file 1: Figure S1. Overall technical route of this project. Figure S2. Reproducibility analysis of this project. Figure S3. QC validation of MS data. (A) Mass error distribution of all identified peptides, (B) Peptide length distribution. Figure S4. Distribution of quantification results (at least 1.5-fold up-or downregulated). Figure S5. Protein domain enrichment analysis of upregulated (A) and downregulated (B) proteins (B vs A). Table S3. TMT-Labeling information. Table S4. Baseline Characteristics of the HIV/TM-coinfected-and HIV-mono-infected individual groups in verification samples.
Picard groups and duality for Real Morava $E$-theories
Creators: name: Heard, Drew
name: Li, Guchuan
name: Shi, XiaoLin Danny
Publisher: name: arXiv
Year: 2018
Subjects: subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics

description: We show, at the prime 2, that the Picard group of invertible modules over $E_n^{hC_2}$ is cyclic. Here, $E_n$ is the height $n$ Lubin--Tate spectrum and its $C_2$-action is induced from the formal inverse of its associated formal group law. We further show that $E_n^{hC_2}$ is Gross--Hopkins self-dual and determine the exact shift. Our results generalize the well-known results when $n = 1$.
description: v3: Version to appear Algebraic and Geometric Topology