The Dementias Platform UK (DPUK) Data Portal
Creators: name: Bauermeister, Sarah
name: Orton, Christopher
name: Thompson, Simon
name: Barker, Roger A.
name: Bauermeister, Joshua R.
name: Ben-Shlomo, Yoav
name: Brayne, Carol
name: Burn, David
name: Campbell, Archie
name: Calvin, Catherine
name: Chandran, Siddharthan
name: Chaturvedi, Nishi
name: Chêne, Geneviève
name: Chessell, Iain P.
name: Corbett, Anne
name: Davis, Daniel H. J.
name: Denis, Mike
name: Dufouil, Carole
name: Elliott, Paul
name: Fox, Nick
name: Hill, Derek
name: Hofer, Scott M.
name: Hu, Michele T.
name: Jindra, Christoph
name: Kee, Frank
name: Kim, Chi-Hun
name: Kim, Changsoo
name: Kivimaki, Mika
name: Koychev, Ivan
name: Lawson, Rachael A.
name: Linden, Gerry J.
name: Lyons, Ronan A.
name: Mackay, Clare
name: Matthews, Paul M.
name: McGuiness, Bernadette
name: Middleton, Lefkos
name: Moody, Catherine
name: Moore, Katrina
name: Na, Duk L.
name: O’Brien, John T.
name: Ourselin, Sebastien
name: Paranjothy, Shantini
name: Park, Ki-Soo
name: Porteous, David J.
name: Richards, Marcus
name: Ritchie, Craig W.
name: Rohrer, Jonathan D.
name: Rossor, Martin N.
name: Rowe, James B.
name: Scahill, Rachael
name: Schnier, Christian
name: Schott, Jonathan M.
name: Seo, Sang W.
name: South, Matthew
name: Steptoe, Matthew
name: Tabrizi, Sarah J.
name: Tales, Andrea
name: Tillin, Therese
name: Timpson, Nicholas J.
name: Toga, Arthur W.
name: Visser, Pieter-Jelle
name: Wade-Martins, Richard
name: Wilkinson, Tim
name: Williams, Julie
name: Wong, Andrew
name: Gallacher, John E. J.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Data Resource
Cohorts
Epidemiology
Data platform
Data repository
Data access
Data management

description: Abstract: The Dementias Platform UK Data Portal is a data repository facilitating access to data for 3 370 929 individuals in 42 cohorts. The Data Portal is an end-to-end data management solution providing a secure, fully auditable, remote access environment for the analysis of cohort data. All projects utilising the data are by default collaborations with the cohort research teams generating the data. The Data Portal uses UK Secure eResearch Platform infrastructure to provide three core utilities: data discovery, access, and analysis. These are delivered using a 7 layered architecture comprising: data ingestion, data curation, platform interoperability, data discovery, access brokerage, data analysis and knowledge preservation. Automated, streamlined, and standardised procedures reduce the administrative burden for all stakeholders, particularly for requests involving multiple independent datasets, where a single request may be forwarded to multiple data controllers. Researchers are provided with their own secure ‘lab’ using VMware which is accessed using two factor authentication. Over the last 2 years, 160 project proposals involving 579 individual cohort data access requests were received. These were received from 268 applicants spanning 72 institutions (56 academic, 13 commercial, 3 government) in 16 countries with 84 requests involving multiple cohorts. Projects are varied including multi-modal, machine learning, and Mendelian randomisation analyses. Data access is usually free at point of use although a small number of cohorts require a data access fee.