cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Discovery of GeV emission from the direction of the luminous infrared galaxy NGC 2146
Creators: name: Tang, Qing-Wen
name: Wang, Xiang-Yu
name: Tam, Pak-Hin Thomas
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Recent detection of high-energy gamma-ray emission from starburst galaxies M82 and NGC 253 suggests that starburst galaxies are huge reservoirs of cosmic rays and these cosmic rays convert a significant fraction of their energy into gamma-rays by colliding with the dense interstellar medium. In this paper, we report the search for high-energy gamma-ray emission from several nearby star-forming and starburst galaxies using the 68 month data obtained with the Fermi Large Area Telescope. We found a $\sim5.5σ$ detection of gamma-ray emission above 200{\rm MeV} from a source spatially coincident with the location of the luminous infrared galaxy NGC~2146. Taking into account also the temporal and spectral properties of the gamma-ray emission, we suggest that the gamma-ray source is likely to be the counterpart of NGC~2146. The gamma-ray luminosity suggests that cosmic rays in NGC~2146 convert most of their energy into secondary pions, so NGC~2146 is a "proton calorimeter". It is also found that NGC~2146 obeys the quasi-linear scaling relation between the gamma-ray luminosity and total infrared luminosity for star-forming galaxies, strengthening the connection between massive star formation and gamma-ray emission of star-forming galaxies. Possible TeV emission from NGC~2146 is predicted and the implications for high-energy neutrino emission from starburst galaxies are discussed.
description: Accepted by ApJ, discussions revised following the referee report, results and conclusions unchanged
Genome-wide Characterization of Shared and Distinct Genetic Components that Influence Blood Lipid Levels in Ethnically Diverse Human Populations
Creators: name: Tang, Hua
name: Duan, Qing
name: Johnson, Nicholas A.
name: Coram, Marc A.
name: Martin, Lisa W.
name: Risch, Neil J.
name: Kooperberg, Charles
name: Thornton, Timothy
name: Hoffmann, Thomas J.
name: Ochs-Balcom, Heather M.
name: Zhu, Xiaofeng
name: Reiner, Alex P.
name: Robinson, Jennifer G.
name: Knowles, Joshua W.
name: Donlon, Timothy A.
name: Eaton, Charles B.
name: Li, Yun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Blood lipid concentrations are heritable risk factors associated with atherosclerosis and cardiovascular diseases. Lipid traits exhibit considerable variation among populations of distinct ancestral origin as well as between individuals within a population. We performed association analyses to identify genetic loci influencing lipid concentrations in African American and Hispanic American women in the Women’s Health Initiative SNP Health Association Resource. We validated one African-specific high-density lipoprotein cholesterol locus at CD36 as well as 14 known lipid loci that have been previously implicated in studies of European populations. Moreover, we demonstrate striking similarities in genetic architecture (loci influencing the trait, direction and magnitude of genetic effects, and proportions of phenotypic variation explained) of lipid traits across populations. In particular, we found that a disproportionate fraction of lipid variation in African Americans and Hispanic Americans can be attributed to genomic loci exhibiting statistical evidence of association in Europeans, even though the precise genes and variants remain unknown. At the same time, we found substantial allelic heterogeneity within shared loci, characterized both by population-specific rare variants and variants shared among multiple populations that occur at disparate frequencies. The allelic heterogeneity emphasizes the importance of including diverse populations in future genetic association studies of complex traits such as lipids; furthermore, the overlap in lipid loci across populations of diverse ancestral origin argues that additional knowledge can be gleaned from multiple populations.
The Brockett problem in the theory of nonstationary stabilization of linear differential equations
Creators: name: Leonov, Gennadi A.
Publisher: name: Weierstrass Institute
Year: 2000
Subjects: subject: stabilization
subject: transfer function
subject: pendulum
subject: invariant manifold
subject: 93D15
subject: 34H05

description: In the present work a review of algorithms for nonstationary linear stabilization is given. In many cases these algorithms, together with the criterion of nonstabilizing, allow us to obtain a solution of the Brockett problem.
Letter from Paul Nash to John Betjeman, November 28, 1939
Creators: name: Nash, Paul, 1889-1946
Publisher: name: University of Victoria Libraries
Year: 2023
Subjects: subject: Poets, English
valueUri: http://id.worldcat.org/fast/1067870
subject: Poets
valueUri: http://id.worldcat.org/fast/1067778
subject: Wolfe, Humbert, 1885-1940
valueUri: http://id.worldcat.org/fast/4236
subject: Betjeman, John, 1906-1984
valueUri: http://id.worldcat.org/fast/1427507
subject: Modernism (Literature)
valueUri: http://id.worldcat.org/fast/1024455
subject: Authors, English--Correspondence
valueUri: http://id.worldcat.org/fast/821953
subject: Television journalists
valueUri: http://id.worldcat.org/fast/1146949
subject: Authors
valueUri: http://id.worldcat.org/fast/821688
subject: Nash, Paul, 1889-1946
valueUri: http://id.worldcat.org/fast/16173
subject: Literature, Modern
valueUri: http://id.worldcat.org/fast/1000172
subject: Authors, English
valueUri: http://id.worldcat.org/fast/821945

description: Correspondence between John Betjemen and artist Paul Nash. Nash tells Betjeman that he has heard from Humbert Wolfe and that he is acting "urgently" to Betjeman's written request. Nash wishes Betjeman luck with this.
Magnetization plateaux and jumps in a frustrated four-leg spin tube under a magnetic field
Creators: name: Albarracín, F. A. Gómez
name: Arlego, M.
name: Rosales, H. D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We study the ground state phase diagram of a frustrated spin-1/2 four-leg spin tube in an external magnetic field. We explore the parameter space of this model in the regime of all-antiferromagnetic exchange couplings by means of three different approaches: analysis of low-energy effective Hamiltonian (LEH), a Hartree variational approach (HVA) and density matrix renormalization group (DMRG) for finite clusters. We find that in the limit of weakly interacting plaquettes, low-energy singlet, triplet and quintuplet states play an important role in the formation of fractional magnetization plateaux. We study the transition regions numerically and analytically, and find that they are described, at first order in a strong- coupling expansion, by an XXZ spin-1/2 chain in a magnetic field; the second-order terms give corrections to the XXZ model. All techniques provide consistent results which allow us to predict the existence of fractional plateaux in an important region in the space of parameters of the model.
description: 10 pages, 7 figures. Accepted for publication in Physical Review B
Meta-analysis of Gene-Level Associations for Rare Variants Based on Single-Variant Statistics
Creators: name: Monda, Keri L.
name: North, Kari E.
name: Lin, Dan-Yu
name: Ganna, Andrea
name: Day, Felix R.
name: Wheeler, Eleanor
name: Gustafsson, Stefan
name: Fall, Tove
name: Jackson, Anne U.
name: Berndt, Sonja I.
name: Lee, Sang Hong
name: Ingelsson, Erik
name: Vedantam, Sailaja
name: Willer, Cristen J.
name: Justice, Anne E.
name: Esko, Tõnu
name: Workalemahu, Tsegaselassie
name: Luan, Jian’an
name: Hu, Yi-Juan
name: Winkler, Thomas W.
name: Gentilini, Davide
name: Berndt, Sonja I.
name: Hirschhorn, Joel
name: Ganna, Andrea
name: Gustafsson, Stefan
name: Ferreira, Teresa
name: Croteau-Chonka, Damien C.
name: Hu, Yi-Juan
name: Mägi, Reedik
name: Feitosa, Mary F.
name: Randall, Joshua C.
name: Wood, Andrew R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Meta-analysis of genome-wide association studies (GWASs) has led to the discoveries of many common variants associated with complex human diseases. There is a growing recognition that identifying “causal” rare variants also requires large-scale meta-analysis. The fact that association tests with rare variants are performed at the gene level rather than at the variant level poses unprecedented challenges in the meta-analysis. First, different studies may adopt different gene-level tests, so the results are not compatible. Second, gene-level tests require multivariate statistics (i.e., components of the test statistic and their covariance matrix), which are difficult to obtain. To overcome these challenges, we propose to perform gene-level tests for rare variants by combining the results of single-variant analysis (i.e., p values of association tests and effect estimates) from participating studies. This simple strategy is possible because of an insight that multivariate statistics can be recovered from single-variant statistics, together with the correlation matrix of the single-variant test statistics, which can be estimated from one of the participating studies or from a publicly available database. We show both theoretically and numerically that the proposed meta-analysis approach provides accurate control of the type I error and is as powerful as joint analysis of individual participant data. This approach accommodates any disease phenotype and any study design and produces all commonly used gene-level tests. An application to the GWAS summary results of the Genetic Investigation of ANthropometric Traits (GIANT) consortium reveals rare and low-frequency variants associated with human height. The relevant software is freely available.
Postcard from William Plomer to John Betjeman, April 05, 1940
Creators: name: Plomer, William, 1903-1973
Publisher: name: University of Victoria Libraries
Year: 2023
Subjects: subject: Authors, English
valueUri: http://id.worldcat.org/fast/821945
subject: Poets, English
valueUri: http://id.worldcat.org/fast/1067870
subject: Television journalists
valueUri: http://id.worldcat.org/fast/1146949
subject: Authors, English--Correspondence
valueUri: http://id.worldcat.org/fast/821953
subject: Modernism (Literature)
valueUri: http://id.worldcat.org/fast/1024455
subject: Poets
valueUri: http://id.worldcat.org/fast/1067778
subject: Authors
valueUri: http://id.worldcat.org/fast/821688
subject: Literature, Modern
valueUri: http://id.worldcat.org/fast/1000172
subject: Plomer, William, 1903-1973
valueUri: http://id.worldcat.org/fast/32868
subject: Betjeman, John, 1906-1984
valueUri: http://id.worldcat.org/fast/1427507

description: Part of a collection of letters to John Betjeman from William Plomer (British poet, novelist and literary editor). Plomer sends Betjeman a playful postcard to cheer him up while recovering from the flu. Postcard is a photographic image of people playing musical chairs from the "Living Picture Series".
Getting to know you: implementing an interprofessional education program for medical and respiratory therapy students in mechanical ventilation – challenges and lessons learned
Creators: name: Farmer, Mary Jo S
name: Kleppel, Reva
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: The physician and respiratory therapist function as an interprofessional team caring for patients on mechanical ventilation. There is a paucity of research devoted to interprofessional education (IPE) of students from different professions in mechanical ventilation during clinical rotations in the medical intensive care unit (MICU). Student interprofessional education could develop team communication and shared decision-making skills early in training. The uniqueness of this introductory IPE programme is that it occurs during a clinical rotation in a real MICU, as opposed to a pre-clinical simulated campus setting, and it blends students from various educational backgrounds. Medical students and respiratory therapy students from different academic institutions participated in traditional lectures, small interprofessional group case-based problem-solving sessions, MICU bedside teaching sessions, written assessments, and focus groups. Quantitative responses were analyzed using descriptive statistics. Qualitative responses were categorised using the core competencies for Interprofessional Collaborative Practice. The purpose of this introductory IPE programme was to foster opportunities for interprofessional interaction during the student clinical experience while improving knowledge about mechanical ventilation. Qualitative expectations and feedback were predominantly positive. Quantitative responses suggest that students from both disciplines gained knowledge about mechanical ventilation in an IPE setting.
Warm Ice Giant GJ 3470b. II Revised Planetary and Stellar Parameters from Optical to Near-infrared Transit Photometry
Creators: name: Biddle, Lauren I.
name: Pearson, Kyle A.
name: Crossfield, Ian J. M.
name: Fulton, Benjamin J.
name: Ciceri, Simona
name: Eastman, Jason
name: Barman, Travis
name: Mann, Andrew W.
name: Henry, Gregory W.
name: Howard, Andrew W.
name: Williamson, Michael H.
name: Sinukoff, Evan
name: Dragomir, Diana
name: Vican, Laura
name: Mancini, Luigi
name: Southworth, John
name: Greenberg, Adam
name: Turner, Jake D.
name: Thompson, Robert
name: Taylor, Brian W.
name: Levine, Stephen E.
name: Webber, Matthew W.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: It is important to explore the diversity of characteristics of low-mass, low-density planets to understand the nature and evolution of this class of planets. We present a homogeneous analysis of 12 new and 9 previously published broadband photometric observations of the Uranus-sized extrasolar planet GJ 3470b, which belongs to the growing sample of sub-Jovian bodies orbiting M dwarfs. The consistency of our analysis explains some of the discrepancies between previously published results and provides updated constraints on the planetary parameters. Our data are also consistent with previous transit observations of this system. We also provide new spectroscopic measurements of GJ 3470 from 0.33 to 2.42 $μ$$m$ to aid our analysis. We find $R_{\star}$ = 0.48$\pm$0.04 $R_{\odot}$, $M_{\star}$ = 0.51$\pm$0.06 $M_{\odot}$, and $T_{\rm eff}$ = 3652$\pm$50 K for GJ 3470, along with a rotation period of $20.70\pm{0.15}$ d and an R-band amplitude of 0.01 mag, which is small enough that current transit measurements should not be strongly affected by stellar variability. We also present the most precise orbital ephemeris for this system: T$_{o}$ = 2455983.70472$\pm$0.00021 BJD$_{TDB}$, P = 3.3366487$^{+0.0000043}_{-0.0000033}$ d, and we see no evidence for transit timing variations greater than 1 minute. Our reported planet to star radius ratio is 0.07642$\pm$0.00037. The physical parameters of this planet are $R_{p}$ = 3.88$\pm$0.32 $R_{\oplus}$, and $M_{p}$ = 13.73$\pm$1.61 $M_{\oplus}$. Because of our revised stellar parameters, the planetary radius we present is smaller than previously reported values. We also perform a second analysis of the transmission spectrum of the entire ensemble of transit observations to date, supporting the existence of a H$_{2}$ dominated atmosphere exhibiting a strong Rayleigh scattering slope.
description: Submitted to MNRAS Dec 2013, Accepted June 2014, 27 Pages, 6 Figures, 5 Tables, Corrected typo
Mutations in SPAG1 Cause Primary Ciliary Dyskinesia Associated with Defective Outer and Inner Dynein Arms
Creators: name: Chaki, Moumita
name: Raidt, Johanna
name: Jahnke, Charlotte
name: Dougherty, Gerard W.
name: Hjeij, Rim
name: Werner, Claudius
name: Carson, Johnny L.
name: Schueler, Markus
name: Gee, Heon Yung
name: Porath, Jonathan D.
name: Wolf, Whitney E.
name: Loges, Niki T.
name: Wallmeier, Julia
name: Sagel, Scott D.
name: Ostrowski, Lawrence E.
name: Huang, Lu
name: Baktai, György
name: Braun, Daniela A.
name: Olivier, Kenneth N.
name: Hazucha, Milan J.
name: Diaz, Katrina A.
name: Knowles, Michael R.
name: Dell, Sharon D.
name: Otto, Edgar A.
name: Hurd, Toby
name: Halbritter, Jan
name: Pennekamp, Petra
name: Olbrich, Heike
name: Davis, Stephanie D.
name: Ferkol, Thomas W.
name: Leigh, Margaret W.
name: Yin, Weining
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Primary ciliary dyskinesia (PCD) is a genetically heterogeneous, autosomal-recessive disorder, characterized by oto-sino-pulmonary disease and situs abnormalities. PCD-causing mutations have been identified in 20 genes, but collectively they account for only ∼65% of all PCDs. To identify mutations in additional genes that cause PCD, we performed exome sequencing on three unrelated probands with ciliary outer and inner dynein arm (ODA+IDA) defects. Mutations in SPAG1 were identified in one family with three affected siblings. Further screening of SPAG1 in 98 unrelated affected individuals (62 with ODA+IDA defects, 35 with ODA defects, 1 without available ciliary ultrastructure) revealed biallelic loss-of-function mutations in 11 additional individuals (including one sib-pair). All 14 affected individuals with SPAG1 mutations had a characteristic PCD phenotype, including 8 with situs abnormalities. Additionally, all individuals with mutations who had defined ciliary ultrastructure had ODA+IDA defects. SPAG1 was present in human airway epithelial cell lysates but was not present in isolated axonemes, and immunofluorescence staining showed an absence of ODA and IDA proteins in cilia from an affected individual, thus indicating that SPAG1 probably plays a role in the cytoplasmic assembly and/or trafficking of the axonemal dynein arms. Zebrafish morpholino studies of spag1 produced cilia-related phenotypes previously reported for PCD-causing mutations in genes encoding cytoplasmic proteins. Together, these results demonstrate that mutations in SPAG1 cause PCD with ciliary ODA+IDA defects and that exome sequencing is useful to identify genetic causes of heterogeneous recessive disorders.
Postcard from William Plomer to John Betjeman, January 01, 1951
Creators: name: Plomer, William, 1903-1973
Publisher: name: University of Victoria Libraries
Year: 2023
Subjects: subject: Television journalists
valueUri: http://id.worldcat.org/fast/1146949
subject: Authors, English--Correspondence
valueUri: http://id.worldcat.org/fast/821953
subject: Modernism (Literature)
valueUri: http://id.worldcat.org/fast/1024455
subject: Authors
valueUri: http://id.worldcat.org/fast/821688
subject: Literature, Modern
valueUri: http://id.worldcat.org/fast/1000172
subject: Poets
valueUri: http://id.worldcat.org/fast/1067778
subject: Betjeman, John, 1906-1984
valueUri: http://id.worldcat.org/fast/1427507
subject: Poets, English
valueUri: http://id.worldcat.org/fast/1067870
subject: Plomer, William, 1903-1973
valueUri: http://id.worldcat.org/fast/32868
subject: Authors, English
valueUri: http://id.worldcat.org/fast/821945

description: Part of a collection of letters to John Betjeman from William Plomer (British poet, novelist and literary editor). Plomer thanks Betjeman for his Christmas card.
Asymptotics for a Class of Dynamic Recurrent Event Models
Creators: name: Pena, Edsel A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Statistics Theory (math.ST)
subject: FOS: Mathematics
subject: 62N01, 62N02, 62G10

description: Asymptotic properties, both consistency and weak convergence, of estimators arising in a general class of dynamic recurrent event models are presented. The class of models take into account the impact of interventions after each event occurrence, the impact of accumulating event occurrences, the induced informative and dependent right-censoring mechanism due to the data-accrual scheme, and the effect of covariate processes on the recurrent event occurrences. The class of models subsumes as special cases many of the recurrent event models that have been considered in biostatistics, reliability, and in the social sciences. The asymptotic properties presented have the potential of being useful in developing goodness-of-fit and model validation procedures, confidence intervals and confidence bands constructions, and hypothesis testing procedures for the finite- and infinite-dimensional parameters of a general class of dynamic recurrent event models, albeit the models without frailties.
description: 26 pages
Postcard from William Plomer to John Betjeman, March 19, 1950
Creators: name: Plomer, William, 1903-1973
Publisher: name: University of Victoria Libraries
Year: 2023
Subjects: subject: Betjeman, John, 1906-1984
valueUri: http://id.worldcat.org/fast/1427507
subject: Literature, Modern
valueUri: http://id.worldcat.org/fast/1000172
subject: Authors, English
valueUri: http://id.worldcat.org/fast/821945
subject: Plomer, William, 1903-1973
valueUri: http://id.worldcat.org/fast/32868
subject: Poets, English
valueUri: http://id.worldcat.org/fast/1067870
subject: Authors, English--Correspondence
valueUri: http://id.worldcat.org/fast/821953
subject: Modernism (Literature)
valueUri: http://id.worldcat.org/fast/1024455
subject: Poets
valueUri: http://id.worldcat.org/fast/1067778
subject: Television journalists
valueUri: http://id.worldcat.org/fast/1146949
subject: Authors
valueUri: http://id.worldcat.org/fast/821688

description: Part of a collection of letters to John Betjeman from William Plomer (British poet, novelist and literary editor). Plomer declines Betjeman's invitation to visit. Front of postcard shows a house with a sign that says "The Ancient Fig Gardens, Teas Provided" located in Worthing.
Is interprofessional education a valued contributor to interprofessional practice and collaboration within allied health in Australia and New Zealand: A scoping review
Creators: name: Janes, Tina L.
name: Rees, Jenni-Lee
name: Zupan, Barbra
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Research on the value of interprofessional education (IPE), collaboration and practice in the health sector at both a pre- and post-registration level has increased in recent years. A scoping review of Australian and New Zealand studies was conducted on the value of IPE to interprofessional practice in allied health professionals from 2013 to 2019. A scoping review framework was used to identify 109 studies. Twenty-one articles met the eligibility criteria. The studies were grouped into undergraduate students in academic and WIL settings, allied health professionals and clinical educators. Results suggest that IPE is necessary for the maintenance of interprofessional practice and that it is strongly connected to the development of successful communication within the interprofessional environment. Authentic IPE experience and socialization opportunities appear to be major facilitators of interprofessional practice but no consensus regarding the ideal length of time or timing of IPE was found. The studies also provided an insight into facilitators and barriers to successful implementation of IPE and interprofessional practice in rural environments. As IPE has been shown to contribute to improved interprofessional practice and patient outcomes, future research should explore how to create IPE opportunities for implementation within rural communities where adequate resourcing is most challenged.
Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia
Creators: name: Schueler, Markus
name: Davis, Stephanie D.
name: Liu, Yan
name: Bower, Raqual
name: Hellman, Nathan
name: Tritschler, Douglas
name: Olivier, Kenneth N.
name: Chaki, Moumita
name: Zariwala, Maimoona A.
name: Gilberti, Renée M.
name: Otto, Edgar A.
name: Halbritter, Jan
name: Lovric, Svjetlana
name: Carson, Johnny L.
name: Atkinson, Jeffry J.
name: Ferkol, Thomas W.
name: Pittman, Jessica E.
name: Pathak, Narendra
name: Hwang, Daw-Yang
name: Patel-King, Ramila S.
name: Diaz, Katrina A.
name: O’Toole, Eileen
name: Austin-Tse, Christina
name: Hurd, Toby W.
name: Kohl, Stefan
name: Airik, Rannar
name: Noone, Peadar G.
name: Gee, Heon Yung
name: Leigh, Margaret W.
name: Panizzi, Jennifer R.
name: Braun, Daniela A.
name: Porath, Jonathan D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Primary ciliary dyskinesia (PCD) is caused when defects of motile cilia lead to chronic airway infections, male infertility, and situs abnormalities. Multiple causative PCD mutations account for only 65% of cases, suggesting that many genes essential for cilia function remain to be discovered. By using zebrafish morpholino knockdown of PCD candidate genes as an in vivo screening platform, we identified c21orf59, ccdc65, and c15orf26 as critical for cilia motility. c21orf59 and c15orf26 knockdown in zebrafish and planaria blocked outer dynein arm assembly, and ccdc65 knockdown altered cilia beat pattern. Biochemical analysis in Chlamydomonas revealed that the C21orf59 ortholog FBB18 is a flagellar matrix protein that accumulates specifically when cilia motility is impaired. The Chlamydomonas ida6 mutant identifies CCDC65/FAP250 as an essential component of the nexin-dynein regulatory complex. Analysis of 295 individuals with PCD identified recessive truncating mutations of C21orf59 in four families and CCDC65 in two families. Similar to findings in zebrafish and planaria, mutations in C21orf59 caused loss of both outer and inner dynein arm components. Our results characterize two genes associated with PCD-causing mutations and elucidate two distinct mechanisms critical for motile cilia function: dynein arm assembly for C21orf59 and assembly of the nexin-dynein regulatory complex for CCDC65.
Postcard from William Plomer to John Betjeman, April 07, 1966
Creators: name: Plomer, William, 1903-1973
Publisher: name: University of Victoria Libraries
Year: 2023
Subjects: subject: Literature, Modern
valueUri: http://id.worldcat.org/fast/1000172
subject: Poets
valueUri: http://id.worldcat.org/fast/1067778
subject: Poets, English
valueUri: http://id.worldcat.org/fast/1067870
subject: Betjeman, John, 1906-1984
valueUri: http://id.worldcat.org/fast/1427507
subject: Plomer, William, 1903-1973
valueUri: http://id.worldcat.org/fast/32868
subject: Modernism (Literature)
valueUri: http://id.worldcat.org/fast/1024455
subject: Authors
valueUri: http://id.worldcat.org/fast/821688
subject: Authors, English--Correspondence
valueUri: http://id.worldcat.org/fast/821953
subject: Authors, English
valueUri: http://id.worldcat.org/fast/821945
subject: Television journalists
valueUri: http://id.worldcat.org/fast/1146949

description: Part of a collection of letters to John Betjeman from William Plomer (British poet, novelist and literary editor). Plomer informs Betjeman of a commemoration service for Francis Kilvert that is happening in Langley Burrell on Sunday, July 3rd. Front of postcard shows a picture of Right Rev. C. J. Ridgeway, Bishop of Chichester.
ZMYND10 Is Mutated in Primary Ciliary Dyskinesia and Interacts with LRRC6
Creators: name: Dell, Sharon D.
name: Al-Mutairi, Dalal A.
name: Hjeij, Rim
name: Leigh, Margaret W.
name: Kohl, Stefan
name: Morgan, Lucy C.
name: Olbrich, Heike
name: Porath, Jonathan D.
name: Kurkowiak, Małgorzata
name: Gee, Heon Yung
name: Ferkol, Thomas W.
name: Sagel, Scott D.
name: Spear, Philip C.
name: Dougherty, Gerard W.
name: Hurd, Toby W.
name: Hwang, Daw-Yang
name: Adan, Mohamed
name: Olivier, Kenneth N.
name: Halbritter, Jan
name: Zariwala, Maimoona A.
name: Wolf, Whitney E.
name: Sheridan, Eamonn
name: Werner, Claudius
name: Batten, Trevor F.C.
name: Chaki, Moumita
name: Rosenfeld, Margaret
name: Burns, Kimberlie A.
name: Loges, Niki T.
name: Esteve-Rudd, Julian
name: Lovric, Svjetlana
name: Diaz, Katrina A.
name: Pittman, Jessica E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Defects of motile cilia cause primary ciliary dyskinesia (PCD), characterized by recurrent respiratory infections and male infertility. Using whole-exome resequencing and high-throughput mutation analysis, we identified recessive biallelic mutations in ZMYND10 in 14 families and mutations in the recently identified LRRC6 in 13 families. We show that ZMYND10 and LRRC6 interact and that certain ZMYND10 and LRRC6 mutations abrogate the interaction between the LRRC6 CS domain and the ZMYND10 C-terminal domain. Additionally, ZMYND10 and LRRC6 colocalize with the centriole markers SAS6 and PCM1. Mutations in ZMYND10 result in the absence of the axonemal protein components DNAH5 and DNALI1 from respiratory cilia. Animal models support the association between ZMYND10 and human PCD, given that zmynd10 knockdown in zebrafish caused ciliary paralysis leading to cystic kidneys and otolith defects and that knockdown in Xenopus interfered with ciliogenesis. Our findings suggest that a cytoplasmic protein complex containing ZMYND10 and LRRC6 is necessary for motile ciliary function.
Postcard from Paul Nash to John Betjeman, October 05, 1939
Creators: name: Nash, Paul, 1889-1946
Publisher: name: University of Victoria Libraries
Year: 2023
Subjects: subject: Literature, Modern
valueUri: http://id.worldcat.org/fast/1000172
subject: Poets, English
valueUri: http://id.worldcat.org/fast/1067870
subject: Poets
valueUri: http://id.worldcat.org/fast/1067778
subject: Authors, English
valueUri: http://id.worldcat.org/fast/821945
subject: Television journalists
valueUri: http://id.worldcat.org/fast/1146949
subject: Authors, English--Correspondence
valueUri: http://id.worldcat.org/fast/821953
subject: Authors
valueUri: http://id.worldcat.org/fast/821688
subject: Modernism (Literature)
valueUri: http://id.worldcat.org/fast/1024455
subject: Nash, Paul, 1889-1946
valueUri: http://id.worldcat.org/fast/16173
subject: Betjeman, John, 1906-1984
valueUri: http://id.worldcat.org/fast/1427507

description: Correspondence between John Betjemen and artist Paul Nash. Nash asks Betjeman if he could bring any writers' dossiers when they meet on Saturday. He also asks Betjeman to bring John Piper with him.
A Common Functional Regulatory Variant at a Type 2 Diabetes Locus Upregulates ARAP1 Expression in the Pancreatic Beta Cell
Creators: name: Mohlke, Karen L.
name: Fuchsberger, Christian
name: Kuusisto, Johanna
name: Laakso, Markku
name: Boehnke, Michael
name: Stitzel, Michael L.
name: Collins, Francis S.
name: Huyghe, Jeroen R.
name: Morken, Mario A.
name: Kulzer, Jennifer R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Genome-wide association studies (GWASs) have identified more than 70 loci associated with type 2 diabetes (T2D), but for most, the underlying causal variants, associated genes, and functional mechanisms remain unknown. At a T2D- and fasting-proinsulin-associated locus on 11q13.4, we have identified a functional regulatory DNA variant, a candidate target gene, and a plausible underlying molecular mechanism. Fine mapping, conditional analyses, and exome array genotyping in 8,635 individuals from the Metabolic Syndrome in Men study confirmed a single major association signal between fasting proinsulin and noncoding variants (p = 7.4 × 10−50). Measurement of allele-specific mRNA levels in human pancreatic islet samples heterozygous for rs11603334 showed that the T2D-risk and proinsulin-decreasing allele (C) is associated with increased ARAP1 expression (p < 0.02). We evaluated four candidate functional SNPs for allelic effects on transcriptional activity by performing reporter assays in rodent pancreatic beta cell lines. The C allele of rs11603334, located near one of the ARAP1 promoters, exhibited 2-fold higher transcriptional activity than did the T allele (p < 0.0001); three other candidate SNPs showed no allelic differences. Electrophoretic mobility shift assays demonstrated decreased binding of pancreatic beta cell transcriptional regulators PAX6 and PAX4 to the rs11603334 C allele. Collectively, these data suggest that the T2D-risk allele of rs11603334 could abrogate binding of a complex containing PAX6 and PAX4 and thus lead to increased promoter activity and ARAP1 expression in human pancreatic islets. This work suggests that increased ARAP1 expression might contribute to T2D susceptibility at this GWAS locus.
Postcard from William Plomer to John Betjeman, February 23, 1938
Creators: name: Plomer, William, 1903-1973
Publisher: name: University of Victoria Libraries
Year: 2023
Subjects: subject: Poets
valueUri: http://id.worldcat.org/fast/1067778
subject: Literature, Modern
valueUri: http://id.worldcat.org/fast/1000172
subject: Betjeman, John, 1906-1984
valueUri: http://id.worldcat.org/fast/1427507
subject: Television journalists
valueUri: http://id.worldcat.org/fast/1146949
subject: Authors, English
valueUri: http://id.worldcat.org/fast/821945
subject: Modernism (Literature)
valueUri: http://id.worldcat.org/fast/1024455
subject: Authors
valueUri: http://id.worldcat.org/fast/821688
subject: Authors, English--Correspondence
valueUri: http://id.worldcat.org/fast/821953
subject: Plomer, William, 1903-1973
valueUri: http://id.worldcat.org/fast/32868
subject: Poets, English
valueUri: http://id.worldcat.org/fast/1067870

description: Part of a collection of letters to John Betjeman from William Plomer (British poet, novelist and literary editor). Plomer thanks Betjeman for his feedback on his satire The Dorking Thigh. Postcard postmarked February 23, 1938, 1130am, from Brighton and Hove, Sussex. Postcard is titled "For England, Home and Beauty" by Raphael Tuck & Sons.
X-ray time delays from the Seyfert 2 galaxy IRAS 18325-5926
Creators: name: Lobban, Andrew
name: Alston, William
name: Vaughan, Simon
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Using new XMM-Newton observations we detect hard X-ray time lags in the rapid variability of the Compton-thin Seyfert 2 galaxy IRAS 18325-5926. The higher-energy X-ray variations lag behind correlated lower-energy variations by up to ~3ks and the magnitude of the lag increases clearly with energy separation between the energy bands. We find that the lag-energy spectrum has a relatively simple log(E) shape. This is quite different in both shape and magnitude from the lags predicted by simple reflection models, but very similar to the hard X-ray lags often seen in black hole X-ray binaries. We apply several spectral models to the lag-energy spectrum and rule out simple reflection as an origin for the hard lags. We find that both propagating fluctuations embedded in the accretion flow and electron scattering from material embedded in or behind a cold absorbing medium offer equally good fits to the observed low-frequency hard X-ray lags and are both consistent with the time-averaged spectrum. Such models will likely look very different outside of XMM-Newton's observable bandpass, paving the way for future studies with NuSTAR.
description: Accepted for publication in MNRAS: 10 pages, 5 figures, 2 tables
Recovering information of tunneling spectrum from Weakly Isolated Horizon
Creators: name: Chen, Ge-Rui
name: Huang, Yong-Chang
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: In this paper we investigate the properties of tunneling spectrum from weakly isolated horizon(WIH). We find that there are correlations among Hawking radiations from weakly isolated horizon, the information can be carried out in terms of correlations between sequential emissions, and the radiation is an entropy conservation process. We generalize Refs.[11-13]' results to a more general spacetime. Through revisiting the calculation of tunneling spectrum of weakly isolated horizon, we find that Ref.[12]'s requirement that radiating particles have the same angular momenta of unit mass as that of black hole is not needed, and the energy and angular momenta of emitting particles are very arbitrary which should be restricted only by keeping the cosmic censorship of black hole.
Metallic Surface States Probed Within the Microwave Skin Depth of the Putative Topological Insulator YBiPt Compound
Creators: name: Lesseux, G. G.
name: Garitezi, T. M.
name: Rosa, P. F. S.
name: Jesus, C. B. R.
name: Urbano, R. R.
name: Pagliuso, P. G.
name: Oseroff, S. B.
name: Sarrao, J. L.
name: Fisk, Z.
name: Rettori, C.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Electron Spin Resonance (ESR) experiments of diluted Nd$^{3+}$ ions in the claimed topological insulator (TI) YBiPt are reported. Powdered samples with grain size from $\approx$ 100 $μ$m to $\approx$ 2,000 $μ$m were investigated. At low temperatures, 1.6 K $\lesssim$ \emph{T} $\lesssim$ 20 K, the X-band ($9.4$ GHz) ESR spectra show a \emph{g}-value of 2.66(4) and a Dysonian resonance lineshape which shows a remarkably unusual temperature, concentration, microwave power and particle size dependence. These results indicate that metallic and insulating behavior coexist within a skin depth of $δ\approx$ 15 $μ$m. Furthermore, the Nd$^{3+}$ spin dynamics in YBiPt are consistent with the existence of a \emph{phonon-bottleneck process} which allows the energy absorbed by the Nd$^{3+}$ ions at resonance to reach the thermal bath via the conduction electrons in the metallic surface states of YBiPt. These results are discussed in terms of the claimed topological semi-metal properties of YBiPt.
description: 8 pages, 10 figures
Association of Low-Frequency and Rare Coding-Sequence Variants with Blood Lipids and Coronary Heart Disease in 56,000 Whites and Blacks
Creators: name: Lohman, Kurt
name: Jackson, Rebecca D.
name: Redon, Valeska
name: Peloso, Gina M.
name: Bis, Joshua C.
name: Voorman, Arend
name: Mackey, Rachel H.
name: Morrison, Alanna C.
name: Feitosa, Mary F.
name: Crosby, Jacy R.
name: Khetarpal, Sumeet A.
name: Davies, Gail
name: Ryckman, Kelli K.
name: Zanoni, Paolo
name: Carlson, Christopher
name: Isaacs, Aaron
name: Smith, Albert V.
name: Huffman, Jennifer E.
name: Stitziel, Nathan O.
name: Auer, Paul L.
name: Manichaikul, Ani
name: Brody, Jennifer A.
name: Davis, Brian
name: Grove, Megan L.
name: Lawson, Kim
name: Demissie, Serkalem
name: Jakobsdottir, Johanna
name: Robinson, Jennifer G.
name: Peters, Ulrike
name: Siscovick, David S.
name: Joon, Aron Y.
name: Fornage, Myriam
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Low-frequency coding DNA sequence variants in the proprotein convertase subtilisin/kexin type 9 gene (PCSK9) lower plasma low-density lipoprotein cholesterol (LDL-C), protect against risk of coronary heart disease (CHD), and have prompted the development of a new class of therapeutics. It is uncertain whether the PCSK9 example represents a paradigm or an isolated exception. We used the “Exome Array” to genotype >200,000 low-frequency and rare coding sequence variants across the genome in 56,538 individuals (42,208 European ancestry [EA] and 14,330 African ancestry [AA]) and tested these variants for association with LDL-C, high-density lipoprotein cholesterol (HDL-C), and triglycerides. Although we did not identify new genes associated with LDL-C, we did identify four low-frequency (frequencies between 0.1% and 2%) variants (ANGPTL8 rs145464906 [c.361C>T; p.Gln121∗], PAFAH1B2 rs186808413 [c.482C>T; p.Ser161Leu], COL18A1 rs114139997 [c.331G>A; p.Gly111Arg], and PCSK7 rs142953140 [c.1511G>A; p.Arg504His]) with large effects on HDL-C and/or triglycerides. None of these four variants was associated with risk for CHD, suggesting that examples of low-frequency coding variants with robust effects on both lipids and CHD will be limited.
Cognitive control is quickly adapted to actual task requirements despite misleading context cues—Evidence from the N2, CRN, and ERN
Creators: name: Grützmann, Rosa
name: Kathmann, Norbert
name: Heinzel, Stephan
Publisher: name: Humboldt-Universität zu Berlin
Year: 2021
Subjects: subject: cognitive control
subject: CRN
subject: ERN
subject: N2
subject: proportion congruency effect
subject: task set
subject: 150 Psychologie

description: Cognitive control is flexibly adapted to task requirements in healthy individuals. Medio-frontal negativities in the event-related potential of the electroencephalogram can serve as indicators of cognitive control. With increasing conflict frequency, stimulus-locked control, as indexed by the N2, is increased and response-locked control, as indexed by the correct-related negativity, is reduced. On the behavioral level, this shift is associated with improved conflict resolution as evident in reduced response times and error rates in incompatible trials and a reduced response time congruency effect. Cognitive control adaptation might be implemented through experience-based task sets specifying advantageous processing strategies. Here, we investigated whether the cognitive control task set will be sustained when coupled with a contextual cue, even when the initial task requirements are no longer present. A flanker task with two conflict frequency conditions (25% incompatible and 75% incompatible trials) was presented. In the training phase, the conflict frequency conditions were paired with a distinct context cue (i.e., background color). In the test phase, the previously associated cues were again presented, but conflict frequency was identical in both conditions (50% incompatible trials). Although typical cognitive control adaptation was observed in the training phase on the behavioral and event-related potentials level, this pattern was not sustained in the test phase. Thus, the present study provides further evidence that cognitive control is flexibly adapted to task requirements even in the presence of misleading cues.
Postcard from William Plomer to John Betjeman, April 03, 1950
Creators: name: Plomer, William, 1903-1973
Publisher: name: University of Victoria Libraries
Year: 2023
Subjects: subject: Literature, Modern
valueUri: http://id.worldcat.org/fast/1000172
subject: Authors
valueUri: http://id.worldcat.org/fast/821688
subject: Poets
valueUri: http://id.worldcat.org/fast/1067778
subject: Betjeman, John, 1906-1984
valueUri: http://id.worldcat.org/fast/1427507
subject: Authors, English--Correspondence
valueUri: http://id.worldcat.org/fast/821953
subject: Authors, English
valueUri: http://id.worldcat.org/fast/821945
subject: Poets, English
valueUri: http://id.worldcat.org/fast/1067870
subject: Modernism (Literature)
valueUri: http://id.worldcat.org/fast/1024455
subject: Television journalists
valueUri: http://id.worldcat.org/fast/1146949
subject: Plomer, William, 1903-1973
valueUri: http://id.worldcat.org/fast/32868

description: Part of a collection of letters to John Betjeman from William Plomer (British poet, novelist and literary editor). Plomer informs Betjeman that he has decided not to travel to Cincinnati, despite Betjeman's efforts. Front of postcard shows picture of "The Mill School" with a quote underneath: "Yes there is holy pleasure in thine eyes, The lovely cottage in the golden nook".
Significance quest by the virtue of religion: Motivational imbalance predicts the personal significance through normative (vs. non-normative) religious self-sacrifice in a Muslim majority context
Creators: name: Firdiani, Norberta
name: Hudijana, Joevarian
name: Szumowska, Ewa
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: Life Sciences
subject: motivational imbalance
subject: personal significance
subject: religious
subject: self-sacrifice

description: This study examine the relationship between motivational imbalance (independent variable) and personal significance (dependent variable) which is mediated by religious self-sacrifice (normative vs non-normative).
Causal Effects of Body Mass Index on Cardiometabolic Traits and Events: A Mendelian Randomization Analysis
Creators: name: Siscovick, David S.
name: Buxbaum, Sarah
name: Tsai, Michael Y.
name: Elbers, Clara C.
name: Lanktree, Matthew B.
name: Patel, Sanjay R.
name: Fornage, Myriam
name: Redline, Susan
name: Price, Tom S.
name: de Bakker, Paul I.W.
name: Almoguera, Berta
name: van der Schouw, Yvonne T.
name: Cushman, Mary
name: Palmer, Tom
name: Li, Jin
name: Schadt, Eric E.
name: Curtis, Sean P.
name: Asselbergs, Folkert W.
name: Rich, Stephen S.
name: Casas, Juan P.
name: Hoogeveen, Ron C.
name: Lange, Leslie A.
name: Guo, Yiran
name: Chandrupatla, Hareesh R.
name: Li, Yun R.
name: Holmes, Michael V.
name: Hingorani, Aroon D.
name: North, Kari E.
name: Wilson, James G.
name: Swerdlow, Daniel I.
name: FitzGerald, Garret A.
name: Hakonarson, Hakon
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: (The American Journal of Human Genetics 94, 198–208; February 6, 2014)
Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci
Creators: name: Nelson, Christopher P.
name: Kleber, Marcus E.
name: Guo, Wei
name: Gieger, Christian
name: Ganesh, Santhi K.
name: McDonough, Caitrin W.
name: Pankratz, Nathan
name: Lanktree, Matthew B.
name: Farrall, Martin
name: Gaunt, Tom R.
name: Fischer, Mary E.
name: Barnes, Michael R.
name: Karczewski, Konrad J.
name: Barnard, John
name: Chang, Yen-Pei Christy
name: Smith, Erin N.
name: Meijs, Matthijs F.L.
name: Melander, Olle
name: Gong, Yan
name: Almoguera, Berta
name: Leach, Irene Mateo
name: Gho, Johannes M.I.H.
name: Baumert, Jens
name: Isaacs, Aaron
name: Franceschini, Nora
name: Holmes, Michael V.
name: Padmanabhan, Sandosh
name: Johnson, Toby
name: Nolte, Ilja M.
name: Tragante, Vinicius
name: Goel, Anuj
name: Elbers, Clara C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Blood pressure (BP) is a heritable risk factor for cardiovascular disease. To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP), we genotyped ∼50,000 SNPs in up to 87,736 individuals of European ancestry and combined these in a meta-analysis. We replicated findings in an independent set of 68,368 individuals of European ancestry. Our analyses identified 11 previously undescribed associations in independent loci containing 31 genes including PDE1A, HLA-DQB1, CDK6, PRKAG2, VCL, H19, NUCB2, RELA, HOXC@ complex, FBN1, and NFAT5 at the Bonferroni-corrected array-wide significance threshold (p < 6 × 10−7) and confirmed 27 previously reported associations. Bioinformatic analysis of the 11 loci provided support for a putative role in hypertension of several genes, such as CDK6 and NUCB2. Analysis of potential pharmacological targets in databases of small molecules showed that ten of the genes are predicted to be a target for small molecules. In summary, we identified previously unknown loci associated with BP. Our findings extend our understanding of genes involved in BP regulation, which may provide new targets for therapeutic intervention or drug response stratification.