cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Vers une protection durable des cultures
Creators: name: Bär, Susanne
name: Foit, Kaarina Pirko
name: Heß, Michael
name: Knillmann, Saskia
name: Kotschik, Pia
name: Kuppe, Konstantin
name: Matezki, Steffen
name: Müller, Alexandra
name: Otto, Sally
name: Petzold, Nora
name: Pieper, Silvia
name: Wogram, Jörn
Publisher: name: Umweltbundesamt
Year: 2022
Subjects: subject: Règlement européen
subject: agriculture durable
subject: protection des cultures
subject: pesticides
subject: lutte intégrée
subject: zones protégées
subject: protection de la biodiversité
subject: Chemikalien
subject: Luft
subject: Wasser
subject: Nachhaltigkeit | Strategien | Internationales

description: Dans la proposition de règlement concernant une utilisation des produits phytopharmaceutiques compatible avec le développement durable, la Commission européenne concrétise l'objectif de réduction de 50 % des pesticides de la stratégie "Farm-to-fork". Le développement d'une agriculture durable est cadrée par une mise en œuvre juridiquement contraignante de la lutte intégrée. Mais pour que les mesures contribuent à la préservation des écosystèmes sensibles des paysages agricoles, d'autres conditions sont nécessaires. Ce Scientific Opinion Paper explique, dans une perspective environnementale, quatre propositions d'amélioration de la Directive SUR qui permettraient d'atteindre cet objectif. Quelle: www.umweltbundesamt.de
description: Dans la proposition de règlement concernant une utilisation des produits phytopharmaceutiques compatible avec le développement durable, la Commission européenne concrétise l'objectif de réduction de 50 % des pesticides de la stratégie « Farm-to-fork». Le développement d’une agriculture durable est cadrée par une mise en œuvre juridiquement contraignante de la lutte intégrée. Mais pour que les mesures contribuent à la préservation des écosystèmes sensibles des paysages agricoles, d'autres conditions sont nécessaires. Ce Scientific Opinion Paper explique, dans une perspective environnementale, quatre propositions d'amélioration de la Directive SUR qui permettraient d'atteindre cet objectif.
title: Hallazgos radiológicos de los tumores y pseudotumores del codo
Creators: name: Ares Vidal, Jesús
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Musculoskeletal soft tissue
subject: Ultrasound
subject: CT
subject: MR

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
-Revisar la anatomía codo. -Describir los hallazgos radiológicos de las lesiones que hemos recopilado durante los últimos años,
localizadas en el codo y catalogadas como lesiones tumores y/o pseudotumores,
excluyendo las lesiones óseas....
Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia
Creators: name: Howitt, Jason
name: Lackovic, Jenny
name: Low, Ley-Hian
name: Naguib, Adam
name: Macintyre, Alison
name: Goh, Choo-Peng
name: Callaway, Jennifer K.
name: Hammond, Vicki
name: Thomas, Tim
name: Dixon, Matthew
name: Putz, Ulrich
name: Silke, John
name: Bartlett, Perry
name: Yang, Baoli
name: Kumar, Sharad
name: Trotman, Lloyd C.
name: Tan, Seong-Seng
Publisher: name: Swinburne
Year: 2024

description: PTEN (phosphatase and tensin homologue deleted on chromosome TEN) is the major negative regulator of phosphatidylinositol 3-kinase signaling and has cell-specific functions including tumor suppression. Nuclear localization of PTEN is vital for tumor suppression; however, outside of cancer, the molecular and physiological events driving PTEN nuclear entry are unknown. In this paper, we demonstrate that cytoplasmic Pten was translocated into the nuclei of neurons after cerebral ischemia in mice. Critically, this transport event was dependent on a surge in the Nedd4 family–interacting protein 1 (Ndfip1), as neurons in Ndfip1-deficient mice failed to import Pten. Ndfip1 binds to Pten, resulting in enhanced ubiquitination by Nedd4 E3 ubiquitin ligases. In vitro, Ndfip1 overexpression increased the rate of Pten nuclear import detected by photobleaching experiments, whereas Ndfip1−/− fibroblasts showed negligible transport rates. In vivo, Ndfip1 mutant mice suffered larger infarct sizes associated with suppressed phosphorylated Akt activation. Our findings provide the first physiological example of when and why transient shuttling of nuclear Pten occurs and how this process is critical for neuron survival.
title: Untersuchungsbericht 86_051110
title: Alterung/Materialbeständigkeit von 19 Zeitungsseiten aus der Staatsbibliothek zu Berlin
titleType: Subtitle
Creators: name: Gomez Sanchez, Elena
name: Simon, Stefan
Publisher: name: Rathgen-Forschungslabor der Staatlichen Museen zu Berlin
Year: 2012
Subjects: Conservation science

description: Das KUR-Projekt "Stabilisierung zerfallsgefährdeter Zeitungsseiten" hat die Entwicklung einer Technologie zur Stabilisierung geschädigter Zeitungsseiten, die ihre mechanische Festigkeit verloren haben, aus dem Bestand der Staatsbibliothek Berlin zum Ziel. Damit soll deren Digitalisierung zur Erhaltung der Informationen ermöglicht werden.
Das Projekt wurde von der Staatsbibliothek zu Berlin, Stiftung Preußischer Kulturbesitz mit den Kooperationspartnern Fraunhofer-Institut für Angewandte Polymerforschung, Potsdam sowie Staatliche Akademie der Bildenden Künste Stuttgart zwischen 2008 und 2011durchgeführt. Im Rathgen-Forschungslabor wurden in diesem Rahmen ab 2010 Versuche der künstlichen Alterung an originalen und nach dem im Projekt entwickelten Verfahren laminierte Zeitungsseiten durchgeführt. Ziel war die Beurteilung der Kompatibilität und Dauerhaftigkeit des Konservierungsverfahrens.
Comparison of Four Methods to Assess Erosive Substance Loss of Dentin
Creators: name: Schwendicke, Falk
name: Felstehausen, Geert
name: Carey, Clifton
name: Dörfer, Christof
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Erosion of dentin results in a complex multi-layered lesion. Several methods have been used to measure erosive substance loss of dentin, but were found to have only limited agreement, in parts because they assess different structural parameters. The present study compared the agreement of four different methods (transversal microradiography [TMR], Confocal Laser Scanning Microscopy [CLSM], Laser Profilometry [LPM] and modified Knoop Hardness measurement [KHM]) to measure erosive substance loss in vitro. Ninety-six dentin specimens were prepared from bovine roots, embedded, ground, polished and covered with nail-varnish except for an experimental window. Erosion was performed for 1 h using citric acid concentrations of 0.00% (control), 0.07%, 0.25% and 1.00% (n = 24/group). Adjacent surfaces served as sound reference. Two examiners independently determined the substance loss. After 1 h erosion with 1% citric acid solution, substance losses (mean±SD) of 12.0±1.3 µm (TMR), 2.9±1.3 µm (LPM), 3.9±1.3 µm (KHM) and 17.0±2.6 µm (CLSM) were detected. ROC curve analysis found all methods to have high accuracy for discriminating different degrees of erosive substance loss (AUC 0.83–1.00). Stepwise discriminatory analysis found TMR and CLSM to have the highest discriminatory power. All methods showed significant relative and proportional bias (p<0.001). The smallest albeit significant disagreement was found between LPM and KHM. No significant inter-rater bias was detected except for KHM. LPM is prone to underestimate erosive loss, possibly due to detection of the organic surface layer. KHM was not found suitable to measure erosive loss in dentin. TMR and CLSM detected the loss of mineralised tissue, showed high reliability, and had the highest discriminatory power. Different methods might be suitable to measure different structural parameters.
The protocol for the Cannabidiol in children with refractory epileptic encephalopathy (CARE-E) study: a phase 1 dosage escalation study
Creators: name: Reithmeier, Darren
name: Tang-Wai, Richard
name: Seifert, Blair
name: Lyon, Andrew W
name: Alcorn, Jane
name: Acton, Bryan
name: Corley, Scott
name: Prosser-Loose, Erin
name: Mousseau, Darrell D
name: Lim, Hyun J
name: Tellez-Zenteno, Jose
name: Huh, Linda
name: Leung, Edward
name: Carmant, Lionel
name: Huntsman, Richard J
Publisher: name: BioMed Central
Year: 2018

description: Background: Initial studies suggest pharmaceutical grade cannabidiol (CBD) can reduce the frequency of convulsive seizures and lead to improvements in quality of life in children affected by epileptic encephalopathies. With limited access to pharmaceutical CBD, Cannabis extracts in oil are becoming increasingly available. Physicians show reluctance to recommend Cannabis extracts given the lack of high quality safety data especially regarding the potential for harm caused by other cannabinoids, such as Δ9-tetrahydrocannabinol (Δ9-THC). The primary aims of the study presented in this protocol are (i) To determine whether CBD enriched Cannabis extract is safe and well-tolerated for pediatric patients with refractory epilepsy, (ii) To monitor the effects of CBD-enriched Cannabis extract on the frequency and duration of seizure types and on quality of life. Methods: Twenty-eight children with treatment resistant epileptic encephalopathy ranging in age from 1 to 10 years will be recruited in four Canadian cities into an open-label, dose-escalation phase 1 trial. The primary objectives for the study are (i) To determine if the CBD-enriched Cannabis herbal extract is safe and well-tolerated for pediatric patients with treatment resistant epileptic encephalopathy and (ii) To determine the effect of CBD-enriched Cannabis herbal extract on the frequency and duration of seizures. Secondary objectives include (i) To determine if CBD-enriched Cannabis herbal extracts alter steady-state levels of co-administered anticonvulsant medications. (ii) To assess the relation between dose escalation and quality of life measures, (iii) To determine the relation between dose escalation and steady state trough levels of bioactive cannabinoids. (iv) To determine the relation between dose escalation and incidence of adverse effects. Discussion: This paper describes the study design of a phase 1 trial of CBD-enriched Cannabis herbal extract in children with treatment-resistant epileptic encephalopathy. This study will provide the first high quality analysis of safety of CBD-enriched Cannabis herbal extract in pediatric patients in relation to dosage and pharmacokinetics of the active cannabinoids. Trial registration http://clinicaltrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2016 Dec 16. Identifier NCT03024827, Cannabidiol in Children with Refractory Epileptic Encephalopathy: CARE-E; 2017 Jan 19 [cited 2017 Oct]; Available from: http://clinicaltrials.gov/ct2/show/NCT03024827
A single cell approach to tumor-infiltrating lymphocytes in solid and hematopoietic malignancies
Creators: name: Hansmann, Leo Alexander
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2019
Subjects: subject: tumor immunology
subject: single cell technologies
subject: human immunology
subject: rectal cancer
subject: multiple myeloma
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: This work is focused on human T and B cell immunology in solid and hematopoietic malignancies. Human immunology has been suffering from insufficiencies to experimentally resolve the virtually unlimited richness of phenotypes and functional states within humans. To at least partially overcome technical limitations, this work presents methodologies for high-dimensional high-throughput determination of lymphocyte differentiation and specificities at the single cell level. The methodologies were applied to rectal cancer and multiple myeloma, which are prime examples for the prognostic impact of tumor-infiltrating T cells or in which the immune system (B cell compartment in multiple myeloma) is part of the malignancy. The included publications present the identification of characteristic-phenotype rectal cancer-infiltrating T cells and, with help of individually created TCR-recombinant reporter cell lines, define the spatial distribution of T cell target antigens within the colo-rectum. In multiple myeloma, the developed methodologies lead to the identification of a novel-phenotype non-plasma cell B lineage subset that is polyclonally expanded in active disease. Furthermore, the phenotypic range of malignant B lineage clones in multiple myeloma was not restricted to plasma cells but included rare normal-phenotype (memory) B cells. This work is novel and of high impact for the (human) immunology field as it i) provides the technical basis to study human lymphocyte biology at the single cell level in high-dimensional space, which is relevant beyond the presented studies on regulatory T cells, rectal cancer, and multiple myeloma. ii) determines accessibility of rectal cancer-infiltrating T cells in peripheral blood. iii) determines the spatial distribution of target antigens of rectal cancer-infiltrating T cells. iv) defines the phenotypic range of multiple myeloma at the single cell level providing a potential rationale for the therapeutic effect of CD19-targeting therapies in a presumably CD19- disease. v) determines the default differentiation pathway of the CD45RA- regulatory T cell subset during in vitro expansion, which is relevant for the design and adoptive transfer of functionally defined cell products.
Functional map of arrestin binding to phosphorylated opsin, with and without agonist
Creators: name: Peterhans, Christian
name: Lally, Ciara C. M.
name: Ostermaier, Martin K.
name: Sommer, Martha E.
name: Standfuss, Joerg
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: Biological fluorescence
subject: High-throughput screening
subject: Protein design
subject: Structural biology
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie

description: Arrestins desensitize G protein-coupled receptors (GPCRs) and act as mediators of signalling. Here we investigated the interactions of arrestin-1 with two functionally distinct forms of the dim-light photoreceptor rhodopsin. Using unbiased scanning mutagenesis we probed the individual contribution of each arrestin residue to the interaction with the phosphorylated apo-receptor (Ops-P) and the agonist-bound form (Meta II-P). Disruption of the polar core or displacement of the C-tail strengthened binding to both receptor forms. In contrast, mutations of phosphate-binding residues (phosphosensors) suggest the phosphorylated receptor C-terminus binds arrestin differently for Meta II-P and Ops-P. Likewise, mutations within the inter-domain interface, variations in the receptor-binding loops and the C-edge of arrestin reveal different binding modes. In summary, our results indicate that arrestin-1 binding to Meta II-P and Ops-P is similarly dependent on arrestin activation, although the complexes formed with these two receptor forms are structurally distinct.
Klärschlammentsorgung in der Bundesrepublik Deutschland
Creators: name: Brandt, Simone
name: Wiechmann, Benjamin
name: Dienemann, Claudia
name: Kabbe, Christian
name: Roskosch, Andrea
name: Vogel, Ines
Publisher: name: My University
Year: 2013
Subjects: subject: Klärschlammbeseitigung
subject: Abfallablagerungsverordnung
subject: Regionalstatistik
subject: Klärschlammbehandlung
subject: Klärschlammtrocknungsanlage
subject: Abfall | Ressourcen
subject: Waste | Resources

description: In Deutschland fallen jährlich etwa zwei Millionen Tonnen Klärschlammtrockensubstanz aus kommunalen Kläranlagen an. Der Anteil von thermisch entsorgten Klärschlämmen stieg von 31,5 % im Jahr 2004 auf über 53 % im Jahr 2010 an. Der Schlamm wird in der Regel verbrannt oder auf landwirtschaftliche Flächen ausgebracht. Klärschlamm enthält eine ganze Reihe von Schadstoffen, die eine Entsorgung mitunter erschweren.
Deep Brain Stimulation of the Subthalamic Nucleus Improves Lexical Switching in Parkinsons Disease Patients
Creators: name: Vonberg, Isabelle
name: Ehlen, Felicitas
name: Fromm, Ortwin
name: Kühn, Andrea A.
name: Klostermann, Fabian
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Objective Reduced verbal fluency (VF) has been reported in patients with Parkinson’s disease (PD), especially those treated by Deep Brain Stimulation of the subthalamic nucleus (STN DBS). To delineate the nature of this dysfunction we aimed at identifying the particular VF-related operations modified by STN DBS. Method Eleven PD patients performed VF tasks in their STN DBS ON and OFF condition. To differentiate VF-components modulated by the stimulation, a temporal cluster analysis was performed, separating production spurts (i.e., ‘clusters’ as correlates of automatic activation spread within lexical fields) from slower cluster transitions (i.e., ‘switches’ reflecting set-shifting towards new lexical fields). The results were compared to those of eleven healthy control subjects. Results PD patients produced significantly more switches accompanied by shorter switch times in the STN DBS ON compared to the STN DBS OFF condition. The number of clusters and time intervals between words within clusters were not affected by the treatment state. Although switch behavior in patients with DBS ON improved, their task performance was still lower compared to that of healthy controls. Discussion Beyond impacting on motor symptoms, STN DBS seems to influence the dynamics of cognitive procedures. Specifically, the results are in line with basal ganglia roles for cognitive switching, in the particular case of VF, from prevailing lexical concepts to new ones.
Process And Design Optimisation In Selective Laser Melting 3D Printed Parts
Creators: name: Rashid, Riyan Abdul Rahman
Publisher: name: Swinburne
Year: 2024

description: Selective laser melting (SLM) is an additive manufacturing or 3D printing process where each metal powder layer is melted and fused by a laser beam. This research project focusses on design and process optimisation of the SLM printed 3D metal parts with the aim of manufacturing high density parts, which could be used to print topology optimised designs for weight reduction. The results of this research provide an insight for developing design strategies, which can not only be used to manufacture parts, but can also predict the mechanical properties of the 3D printed parts and with different design features.
Central limit theorems for set-indexed strong martingales.
Creators: name: Slonowsky, Dean.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Mathematics.

description: In [24], Ivanoff and Merzbach introduced the notion of set-indexed strong martingales, a generalization of the planar strong martingales introduced by Cairoli and Walsh in [10]. A set-indexed strong martingale is a special case of a set-indexed process by which we mean a collection X=XA:A∈A of random variables where A is some collection of subsets of a fixed set T. In this thesis, T is always a compact metric space and A is a semilattice of closed subsets of T. In this thesis, we obtain limit theorems for sequences of set-indexed strong martingales and develop two general tools that are useful in obtaining such limit theorems. These limit theorems establish convergence to set-indexed Gaussian processes in one of two modes, functional or semifunctional. Whereas the former mode of convergence is classic, the latter is entirely new and is particularly well-suited to set-indexed strong martingale central limit theorems. The first tool developed is the establishment of sufficient conditions for compactness in the function space D( A ) defined in [22] under a Skorokhod J2-like metric. D( A ) serves as a set-indexed generalization of the classic function space D[0, 1]. The resulting compact sets lead to tightness criteria for set-indexed processes with sample paths in D( A ). These results extend those found in Section 3 of [5]. For the second tool, quadratic variation for set-indexed strong martingales is defined and conditions ensuring its existence are given. The general role of quadratic variation in set-indexed strong martingale central limit theorems is similar to that played by quadratic variation processes in the classical theory. Namely, under certain conditions, convergence of quadratic variations to a continuous deterministic limit implies convergence of the underlying sequence of set-indexed strong martingales to a suitably scaled set-indexed Gaussian process. As an application, we derive a central limit theorem for set-indexed weighted empirical processes.
Keratin-water-NMF interaction as a three layer model in the human stratum corneum using in vivo confocal Raman microscopy
Creators: name: Choe, ChunSik
name: Schleusener, Johannes
name: Lademann, Juergen
name: Darvin, Maxim E.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: Confocal microscopy
subject: Molecular conformation
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: The secondary and tertiary structure of keratin and natural moisturizing factor (NMF) are of great importance regarding the water regulating functions in the stratum corneum (SC). In this in vivo study, the depth-dependent keratin conformation and its relationship to the hydrogen bonding states of water and its content in the SC, are investigated using confocal Raman microscopy. Based on the obtained depth-profiles for the β-sheet/α-helix ratio, the stability of disulphide bonds, the amount of cysteine forming disulphide bonds, the buried/exposed tyrosine and the folding/unfolding states of keratin, a “three layer model” of the SC, regarding the keratin-water-NMF interaction is proposed. At the uppermost layers (30–0% SC depth), the keratin filaments are highly folded, entailing limited water binding sites, and NMF is mostly responsible for binding water. At the intermediate layers (70–30% SC depth), the keratin filaments are unfolded, have the most water binding sites and are prone to swelling. At the bottom layers (100–80% SC depth), the water binding sites are already occupied with water and cannot swell substantially. The hydrogen bonding states of water molecules can only be explained by considering both, the molecular structure of keratin and the contribution of NMF as a holistic system.
Prüfung der Vollständigkeit der Berichterstattungskategorie 'Keramische Erzeugnisse' insbesondere Emissionsrelevanz feinkeramischer Teilbranchen (Evaluierung in CRF 2.A.4.a/NFR 2.A.6 - AR-Keramik)
Creators: name: Gottwald, Jan
name: Dobritz, Felix
name: Schneider, Lutz
Publisher: name: My University
Year: 2017
Subjects: subject: Emissionsberechnungen
subject: Prozessemissionen
subject: AR-Keramik
subject: Feinkeramik
subject: Emissionsberichterstattung
subject: Teilbranche
subject: Treibhausgasemissionen
subject: Luft

description: Im Projekt prüften die Auftragnehmenden, ob sämtliche relevante Aktivitätsdaten keramischer Teilbranchen aus der amtlichen Statistik für die Emissionsberichterstattung ermittelbar sind. Diese Darstellung erfolgte weitgehend lückenlos. Brüche in der Statistik bzw. Änderungen bei der Berichterstattung wurden identifiziert und dokumentiert. Zusammen mit der Bewertung der Emissionsrelevanz konnten Berechnungen des UBA evaluiert werden. Dabei stand vor allem die Frage im Vordergrund, ob durch die zusätzlich identifizierten Teilbranchen bei der Berechnung der Treibhausgasemissionen in Zeitreihen für die Jahre 1990 bis 2015 mit wesentlichen Veränderungen zu rechnen ist. Quelle: Umweltbundesamt
description: Im Projekt prüften die Auftragnehmenden, ob sämtliche relevante Aktivitätsdaten keramischer Teilbranchen aus der amtlichen Statistik für die Emissionsberichterstattung ermittelbar sind. Diese Darstellung erfolgte weitgehend lückenlos. Brüche in der Statistik bzw. Änderungen bei der Berichterstattung wurden identifiziert und dokumentiert.  Zusammen mit der Bewertung der Emissionsrelevanz konnten Berechnungen des ⁠UBA⁠ evaluiert werden. Dabei stand vor allem die Frage im Vordergrund, ob durch die zusätzlich identifizierten Teilbranchen bei der Berechnung der Treibhausgasemissionen in Zeitreihen für die Jahre 1990 bis 2015 mit wesentlichen Veränderungen zu rechnen ist.
Appendix from The 1978 English boarding school influenza outbreak: where the classic SEIR model fails
Creators: name: Avilov, Konstantin K
name: LI, Qiong
name: Lin, Lixin
name: Demirhan, Haydar
name: Stone, Lewi
name: He, Daihai
Publisher: name: The Royal Society
Year: 2024
Subjects: classificationCode: 490102
subject: Biological mathematics

description: The Appendix with additional information and materials
Geo-tracing of Black Pepper using Metal Oxide Semiconductor Gas Sensors
Creators: name: Lee, Hui En
Publisher: name: Swinburne
Year: 2024

description: Malaysia produces black pepper of superior quality, especially in the state of Sarawak. Sarawak black pepper is widely known in the global market and fetches higher price compared to its competitors. There has been arising concerns of increasing fraud products that claimed their origin to be from Sarawak for better price. Using metal oxide semiconductor gas sensors, this PhD research develops an accurate, inexpensive, rapid, portable and non-invasive geo-tracing method to establish product differentiation of black pepper by geographical origins. Therefore, the higher price of Sarawak black pepper can be justified, and its product can be authenticated against fraud.
The Efficacy of the Quadrivalent Human Papillomavirus Vaccine in Girls and Women Living with HIV
Creators: name: McClymont, Elisabeth
name: Lee, Marette
name: Raboud, Janet
name: Coutlée, François
name: Walmsley, Sharon
name: Lipsky, Nancy
name: Loutfy, Mona
name: Trottier, Sylvie
name: Smaill, Fiona
name: Klein, Marina B.
name: Harris, Marianne
name: Cohen, Jeffrey
name: Yudin, Mark H.
name: Wobeser, Wendy
name: Money, Deborah M.
Publisher: name: The University of British Columbia
Year: 2019

description: Background: Human papillomavirus (HPV) vaccination is safe and efficacious in women without HIV. While good immunogenicity has been observed in women living with HIV (WLWH), efficacy data in this population are needed. Methods: We enrolled 420 females aged ≥9 years (range: 9-65) living with HIV. Participants were to receive 3 doses of qHPV vaccine (0/2/6 months). The main endpoint was vaccine failure (i.e., incident persistent qHPV infection, cervical intraepithelial neoplasia of grade 2 or higher (CIN2+), or genital warts). We compared these rates to published rates in vaccinated and unvaccinated women without HIV as well as unvaccinated WLWH. Results: Among 279 eligible women, median follow-up was 2 years. In the intention-to treat population, the incidence rate (IR) of persistent qHPV (HPV6/11/16/18) was 2.3 per 100 person-years (/100PY) (95% confidence interval [CI]=1.1-4.1) and IR of genital warts was 2.3/100PY (95% CI=1.2-4.1). In the per-protocol efficacy population, IR of persistent qHPV was 1.0/100PY (95% CI=0.3-2.6) and of genital warts was 1.0/100PY (95% CI=0.3-2.5). No cases of CIN2+ occurred. Reported rates of qHPV-related infection and disease within the vaccinated women without HIV, unvaccinated women without HIV, and the vaccinated WLWH: 0.1 (95% CI=0.02-0.03), 1.5 (95% CI=1.1- 2.0), and 1.2 (95% CI=0.2-3.4) /100PY, respectively. The rate of persistent qHPV among vaccinated WLWH was lower than among unvaccinated WLWH (2.3 vs. 6.0/100PY). Conclusions: Vaccinated WLWH may be 53 at higher risk for vaccine failure than vaccinated women without HIV. However, overall rates of vaccine failure were low and rates of persistent qHPV were lower than in unvaccinated WLWH.
Bob Barnes - Washington State Rainbow Coalition Oral History Project - Oral History Transcript
Creators: name: Labor Archives of Washington
Publisher: name: Labor Archives of Washington
Year: 2024

description: Oral History interview with Bob Barnes of the Washington State Rainbow Coalition and Ship Scalers Local 541. Completed on May 30, 2024. This interview is part of the Washington State Rainbow Coalition Oral History Project by the Labor Archives of Washington, University of Washington Libraries. Laborarchives.org

This item contains one part: oral history transcript (.pdf).
Helena Stephens - Washington State Rainbow Coalition Oral History Project - Oral History Transcript
Creators: name: Labor Archives of Washington
Publisher: name: Labor Archives of Washington
Year: 2024

description: Oral History interview with Helena Stephens of the Washington State Rainbow Coalition. Completed on May 2, 2024. This interview is part of the Washington State Rainbow Coalition Oral History Project by the Labor Archives of Washington, University of Washington Libraries. Laborarchives.org

This item contains one part: oral history transcript (.pdf).
The Influence of MgH2 on the Assessment of Electrochemical Data to Predict the Degradation Rate of Mg and Mg Alloys
Creators: name: Mueller, Wolf- Dieter
name: Hornberger, Helga
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2014
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Mg and Mg alloys are becoming more and more of interest for several applications. In the case of biomaterial applications, a special interest exists due to the fact that a predictable degradation should be given. Various investigations were made to characterize and predict the corrosion behavior in vitro and in vivo. Mostly, the simple oxidation of Mg to Mg2+ ions connected with adequate hydrogen development is assumed, and the negative difference effect (NDE) is attributed to various mechanisms and electrochemical results. The aim of this paper is to compare the different views on the corrosion pathway of Mg or Mg alloys and to present a neglected pathway based on thermodynamic data as a guideline for possible reactions combined with experimental observations of a delay of visible hydrogen evolution during cyclic voltammetry. Various reaction pathways are considered and discussed to explain these results, like the stability of the Mg+ intermediate state, the stability of MgH2 and the role of hydrogen overpotential. Finally, the impact of MgH2 formation is shown as an appropriate base for the prediction of the degradation behavior and calculation of the corrosion rate of Mg and Mg alloys.
Functional Aspects of Alcohol Hangover
Creators: name: Ayre, Elizabeth
Publisher: name: Swinburne
Year: 2024

description: Alcohol hangover is a common after-effect of heavy episodic drinking characterized by a combination of physical and mental symptoms that develop when blood alcohol concentration is nearing 0.00%. The objective of this thesis was to explore the effects of alcohol hangover on functional aspects of performance. This thesis demonstrated that core cognitive functions were impaired during alcohol hangover, and these impairments may be distinct from acute intoxication. Impairments in attention and psychomotor processes allude to an impairment in driving ability having implications for safe driving practices. Further research is needed to rectify the personal and economic burden of this phenomenon.
title: PAAF control US del nódulo tiroideo ¿ Hacemos demasiadas?
Creators: name: Montero Rey, Maria Dolores
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Head and neck
subject: Ultrasound
subject: Biopsy
subject: Endocrine disorders

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
INTRODUCCIÓN ( FIG-1 ) Los nódulos tiroideos son muy frecuentes y por tanto representan un problema clínico habitual Los ecógrafos de alta resolución detectan su presencia en más del 60% de los pacientes,
lo que nos enfrenta a una verdadera...
Helena Stephens - Washington State Rainbow Coalition Oral History Project - Oral History Transcript
Creators: name: Labor Archives of Washington
Publisher: name: Labor Archives of Washington
Year: 2024

description: Oral History interview with Helena Stephens of the Washington State Rainbow Coalition. Completed on May 16, 2024. This interview is part of the Washington State Rainbow Coalition Oral History Project by the Labor Archives of Washington, University of Washington Libraries. Laborarchives.org

This item contains one part: oral history transcript (.pdf).
Ex vivo cultures combined with vivo-morpholino induced gene knockdown provide a system to assess the role of WT1 and GATA4 during gonad differentiation
Creators: name: Rudigier, Lucas J.
name: Dame, Christof
name: Scholz, Holger
name: Kirschner, Karin M.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2017
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Gonad morphogenesis relies on the correct spatiotemporal expression of a number of genes that together fulfill the differentiation of the bipotential gonad into testes or ovaries. As such, the transcription factors WT1 and GATA4 are pivotal for proper gonadal development. Here we address the contributions of GATA4 and WT1 to the sex differentiation phase in testes and ovaries. We applied an ex vivo technique for cultivating gonads in hanging droplets of media that were supplemented with vivo-morpholinos to knockdown WT1 and GATA4 either alone or in combination at the same developmental stage. We show that WT1 is equally important for both, the initial establishment and the maintenance of the sex-specific gene expression signature in testes and ovaries. We further identified Foxl2 as a novel putative downstream target gene of WT1. Moreover, knockdown of WT1 reduced mRNA levels of several molecular components of the hedgehog signaling pathway in XY gonads, whereas Gata4 vivo-morpholino treatment increased transcripts of Dhh and Ptch1 in embryonic testes. The data suggest that for its proper function, WT1 relies on the correct expression of the GATA4 protein. Furthermore, GATA4 down-regulates several ovarian promoting genes in testes, such as Ctnnb1, Fst, and Bmp2, suggesting that this repression is required for maintaining the male phenotype. In conclusion, this study provides novel insights into the role of WT1 and GATA4 during the sex differentiation phase and represents an approach that can be applied to assess other proteins with as yet unknown functions during gonadal development.
title: Una Buena Impresión
Creators: name: Gregorio Hernández, Abel
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Education
subject: Professional issues
subject: Perception image
subject: Health policy and practice

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Transmitir una serie de consejos prácticos y técnicas que nos ayudan a ver las cosas desde la perspectiva de otros y adaptar el modo en que nos comportamos para conseguir causar la impresión que queremos,
ganar influencia y presencia ante...
Neuronal Oscillations in Various Frequency Bands Differ between Pain and Touch
Creators: name: Michail, Georgios
name: Dresel, Christian
name: Witkovsky, Viktor
name: Stankewitz, Anne
name: Schulz, Enrico
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: pain
subject: touch
subject: perception
subject: neuronal oscillations
subject: time-frequency analysis
subject: intensity coding
subject: EEG
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Although humans are generally capable of distinguishing single events of pain or touch, recent research suggested that both modalities activate a network of similar brain regions. By contrast, less attention has been paid to which processes uniquely contribute to each modality. The present study investigated the neuronal oscillations that enable a subject to process pain and touch as well as to evaluate the intensity of both modalities by means of Electroencephalography. Nineteen healthy subjects were asked to rate the intensity of each stimulus at single trial level. By computing Linear mixed effects models (LME) encoding of both modalities was explored by relating stimulus intensities to brain responses. While the intensity of single touch trials is encoded only by theta activity, pain perception is encoded by theta, alpha and gamma activity. Beta activity in the tactile domain shows an on/off like characteristic in response to touch which was not observed in the pain domain. Our results enhance recent findings pointing to the contribution of different neuronal oscillations to the processing of nociceptive and tactile stimuli.
title: Utilización sistemática de contraste en los estudios de RM de CAIs por sospecha de neurinoma del acústico. ¿Es necesario con las nuevas secuencias?.
Creators: name: Sales Fernandez, Covadonga
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Cost-effectiveness
subject: MR
subject: Management

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
Valorar la necesidad de administrar contraste paramagnético de forma sistemática en los estudios de RM por sospecha de neurinoma del octavo...
Larry Gossett - Washington State Rainbow Coalition Oral History Project - Oral History Transcript
Creators: name: Labor Archives of Washington
Publisher: name: Labor Archives of Washington
Year: 2024

description: Oral History interview with Larry Gossett of the Washington State Rainbow Coalition, Seattle Black Panther Party, Central Area Motivation Program, and King County Council. Completed on May 24, 2024. This interview is part of the Washington State Rainbow Coalition Oral History Project by the Labor Archives of Washington, University of Washington Libraries. Laborarchives.org

This item contains one part: oral history transcript (.pdf).
Solubility of oxygen in aqueous sulphuric acid-metallic salt solutions under pressure leaching conditions.
Creators: name: Kimweri, Henry Tegani H.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Engineering, Chemical.

description: The densities and equilibrium solubilities of oxygen were determined in aqueous sulphuric acid containing different amounts of dissolved zinc and ferric sulphate at conditions that simulated the conditions used for pressure leaching of zinc sulphide ores. A two-stage absorption-desorption process was used in the determination of the oxygen solubilities. The solutions were saturated with oxygen at high temperatures and pressures and then, the volume of gas desorbed at 101.3 kPa and 323 K, was measured. The solubilities of oxygen in these solutions are closely expressed by Henry's law. The oxygen solubilities were found to be very low, in the order of 10$\sp{-5}$ mole fraction at an oxygen partial pressure of 101.3 kPa. The addition of the sulphuric acid and the metal salts was found to significantly decrease the oxygen solubilities. However, the oxygen solubilities increase with an increase in the partial pressure of oxygen and an increase in temperature. At all temperatures, the densities of these solutions were higher than those of water. The densities of the solutions decreased with an increase in temperature. (Abstract shortened by UMI.)
A role for telomere length and chromosomal damage in idiopathic pulmonary fibrosis
Creators: name: McDonough, John E.
name: Martens, Dries S.
name: Tanabe, Naoya
name: Ahangari, Farida
name: Verleden, Stijn E.
name: Maes, Karen
name: Verleden, Geert M.
name: Kaminski, Naftali
name: Hogg, James C.
name: Nawrot, Tim S.
name: Wuyts, Wim A.
name: Vanaudenaerde, Bart M.
Publisher: name: BioMed Central
Year: 2018

description: Background: Idiopathic pulmonary fibrosis is a fatal lung disease characterized by a progressive formation of fibroblastic foci in the interstitium. This disease is strongly associated with telomere dysfunction but the extent of telomere shortening and consequent chromosomal damage within IPF lungs and with regional disease severity remains unknown. Methods: Explanted IPF lungs (n = 10) were collected from transplant surgeries with six samples per lung analysed to capture the regional heterogeneity ranging from mild to severe disease. Non-used donor lungs (n = 6) were collected as “healthy” controls. Structural changes related to disease severity (microCT surface density), relative telomere length (real-time qPCR), and quantitative histology of chromosomal damage (γ-H2A.X) and extracellular matrix (elastin, total collagen, collagen 1, and collagen 3) were measured. A multivariate linear mixed-effects model controlling for subject was used to identify association of disease severity or fibrotic markers with telomere length and chromosomal damage. Results: We observed shorter telomere length (p = 0.001) and increased chromosomal damage (p = 0.018) in IPF lungs compared to controls. In IPF lungs, telomere length was associated with total collagen (p < 0.001) but not with structural changes of disease severity. Chromosomal damage was positively associated with increased elastin (p = 0.006) and negatively with structural disease severity (p = 0.046). Extensive γ-H2A.X staining was also present in airway epithelial cells. Conclusions: Telomere length and chromosomal damage are involved in IPF with regional variation in telomere length and chromosomal damage associated with pathological changes in tissue structure and the extracellular matrix.
title: Hexamoll® DINCH and DPHP metabolites in urine of children and adolescents in Germany. Human biomonitoring results of the German Environmental Survey GerES V, 2014-2017
title: Hexamoll® DINCH and DPHP metabolites in urine of children and adolescents in Germany
titleType: AlternativeTitle
Creators: name: Conrad, André
name: Kolossa-Gehring, Marike
name: Rucic, Enrico
name: Schmied-Tobies, Maria Irene Hilde
name: Schulz, Christine
name: Schwedler, Gerda
Publisher: name: My University
Year: 2019
Subjects: DINCH
Human-Biomonitoring

description: The production and use of the plasticisers Hexamoll® DINCH (di-(iso-nonyl)-cyclohexane-1,2-dicarboxylate) and DPHP (di-(2-propylheptyl) phthalate) have increased after both chemicals were introduced into the market in the early 2000s as substitutes for restricted high molecular weight phthalates. During the population representative German Environmental Survey (GerES) of Children and Adolescents (GerES V, 2014-2017), we collected urine samples and measured the concentrations of DINCH and DPHP metabolites in 2228 and in a subsample of 516 participants, respectively. We detected DINCH and DPHP metabolites in 100% and 62% of the 3-17 years old children and adolescents, respectively. Geometric means of DINCH metabolites were 2.27 myg/L for OH-MINCH, 0.93 myg/L for oxo-MINCH, 1.14 myg/L for cx-MINCH and 3.47 myg/L for DINCH (Sigma of OH-MINCH + cx-MINCH). Geometric means of DPHP metabolites were 0.30 myg/L for OH-MPHP, 0.32 myg/L for oxo-MPHP and 0.64 myg/L for DPHP (Sigma of OH-MPHP + oxo-MPHP). The 3-5 years old children had almost 3-fold higher DINCH biomarkers levels than adolescents (14-17 years). Higher concentrations of DPHP biomarkers among young children only became apparent after creatinine adjustment. Urinary levels of DINCH but not of DPHP biomarkers were associated with the levels of the respective plasticisers in house dust. When compared to HBM health-based guidance values, we observed no exceedance of the HBM-I value of 1 mg/L for DPHP (Sigma of OH-MPHP + oxo-MPHP). However, 0.04% of the children exceeded the health based guidance value HBM-I of 3 mg/L for DINCH (Sigma of OH-MINCH + cx-MINCH). This finding shows that even a less toxic replacement of restricted chemicals can reach exposures in some individuals, at which, according to current knowledge, health impacts cannot be excluded with sufficient certainty. In conclusion, we provide representative data on DINCH and DPHP exposure of children and adolescents in Germany. Further surveillance is warranted to assess the substitution process of plasticisers, and to advise exposure reduction measures, especially for highly exposed children and adolescents. Providing the results to the European HBM Initiative HBM4EU will support risk assessment and risk management not only in Germany but also in Europe. © 2019 The Authors. Published by Elsevier GmbH
title: Utilidad del TIPS en el transplante hepático
Creators: name: Viteri, Guillermo
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Vascular
subject: Shunts
subject: Liver

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Los objetivos son analizar los posibles beneficios clínicos que se pueden obtener con la realización de TIPS en pacientes que están en la lista de espera para trasplante hepático (TH).
También conocer las indicaciones,
complejidad técnica o...
Increased cortical expression of the zinc transporter SLC39A12 suggests a breakdown in zinc cellular homeostasis as part of the pathophysiology of schizophrenia
Creators: name: Scarr, Elizabeth
name: Udawela, Madhara
name: Greenough, Mark A.
name: Neo, Jaclyn
name: Suk Seo, Myoung
name: Money, Tammie T.
name: Upadhyay, Aradhana
name: Bush, Ashley I.
name: Everall, Ian P.
name: Thomas, Elizabeth A.
name: Dean, Brian
Publisher: name: Swinburne
Year: 2024

description: Our expression microarray studies showed messenger RNA (mRNA) for solute carrier family 39 (zinc transporter), member 12 (SLC39A12) was higher in dorsolateral prefrontal cortex from subjects with schizophrenia (Sz) in comparison with controls. To better understand the significance of these data we ascertained whether SLC39A12 mRNA was altered in a number of cortical regions (Brodmann’s area (BA) 8, 9, 44) from subjects with Sz, in BA 9 from subjects with mood disorders and in rats treated with antipsychotic drugs. In addition, we determined whether inducing the expression of SLC39A12 resulted in an increased cellular zinc uptake. SLC39A12 variant 1 and 2 mRNA was measured using quantitative PCR. Zinc uptake was measured in CHO cells transfected with human SLC39A12 variant 1 and 2. In Sz, compared with controls, SLC39A12 variant 1 and 2 mRNA was higher in all cortical regions studied. The were no differences in levels of mRNA for either variant of SLC39A12 in BA 9 from subjects with mood disorders and levels of mRNA for Slc39a12 was not different in the cortex of rats treated with antipsychotic drugs. Finally, expressing both variants in CHO-K1 cells was associated with an increase in radioactive zinc uptake. As increased levels of murine Slc39a12 mRNA has been shown to correlate with increasing cellular zinc uptake, our data would be consistent with the possibility of a dysregulated zinc homeostasis in the cortex of subjects with schizophrenia due to altered expression of SLC39A12.
Phil Bereano - Washington State Rainbow Coalition Oral History Project - Oral History Transcript
Creators: name: Labor Archives of Washington
Publisher: name: Labor Archives of Washington
Year: 2024

description: Oral History interview with Phil Bereano of the Washington State Rainbow Coalition, ACLU, and ACT UP Seattle. Completed on May 9, 2024. This interview is part of the Washington State Rainbow Coalition Oral History Project by the Labor Archives of Washington, University of Washington Libraries. Laborarchives.org

This item contains one part: oral history transcript (.pdf).