cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Translation and Analysis of Suzanne Myre’s Short Story Collection Mises à mort: A Case Study in Translating the Short Story Cycle
Creators: name: Hildebrand, Cassidy T. R.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Literary translation
short story cycle
short story cycle translation
Suzanne Myre
translation studies
Mises à mort

description: In translation studies, the short story cycle has been largely overlooked as an object of study in prose translation. This thesis serves as a case study on the practice of translating the short story cycle, using my translation of Suzanne Myre’s 2007 short story collection Mises à mort as a paradigm. The thesis comprises four sections: the first is devoted to a discussion of the short story cycle, a modernist form of the short story collection. It is a hybrid subgenre, balancing elements of both the traditional short story collection, characterized by heterogeneity, and the novel, characterized by homogeneity. In this first section, I examine a few definitions of the cycle, then I discuss the subgenre according to a four-part criteria established by Gerald Lynch: ‘character,’ ‘place,’ ‘theme’ and ‘style or tone.’ In the second section, I provide an analysis of Mises à mort within the framework of short story cycle criteria; an examination of the characters, setting, overarching themes and stylistic parallels serves to demonstrate how and why I ultimately interpreted the collection as a short story cycle. The third section is my complete translation of the work. In the fourth and final section, I discuss what implications my interpretation of Mises à mort as a cycle had for my translation thereof, and what unique challenges it presented. I compare my first draft, produced in the mindset that I was translating a traditional collection, to my final draft, revised to accommodate the cohesiveness of the work. This thesis serves to demonstrate how a translator can accommodate for the dual nature of the short story cycle, simultaneously maintaining the discreteness and interconnectedness of the stories.
The Hand that Feeds: NGOs’ Changing Relationship with the Canadian International Development Agency under the Competitive Funding Mechanism
Creators: name: Nazarko, Nuala
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: CIDA-NGO relationship
Official donor funding

description: This thesis analyzes Canadian NGOs’ relationship with the Canadian International Development Agency (CIDA) in the context of the competitive funding mechanism. It captures NGOs’ perspectives on the changing CIDA-NGO relationship, noting the range of NGO responses regarding advocacy efforts, public engagement, organizational priorities and overseas partnerships. The findings indicate that the relationship between CIDA and NGOs cannot be defined as partnership, but rather as one that spans the categories of “contracting” and “extension” in the Brinkerhoff (2002) partnership model. Additionally, employing Elbers and Arts’ (2011) typology, the thesis concludes that NGOs seek to “influence” CIDA through meetings with officers and politicians, “buffer” their partners from negative CIDA impacts, “shield” themselves by limiting their level of CIDA support and “compensate” by funding advocacy and public engagement from internal sources. Moreover, I include “innovation” as an additional strategy that NGOs can employ as a response to donor conditions.
Functional Analysis of Dlx Intergenic Enhancers in the Developing Mouse Forebrain
Creators: name: Fazel Darbandi, Siavash
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Dlx
Chromosome Conformation Capture
Forebrain
Neuronal Migration
Corridor cells
Development
Intergenic enhancers

description: The Distal-less homeobox (Dlx) genes encode a group of transcription factors that are involved in various developmental processes including forebrain development. Dlx genes are arranged in convergently transcribed bigene clusters with enhancer sequences located in the intergenic region of each cluster. The expression patterns of Dlx1/Dlx2 and of Dlx5/Dlx6 are attributed in part to the activity of I12a/I12b and I56i/I56ii intergenic enhancers, respectively. In an effort to determine how Dlx intergenic enhancers interact with the promoter regions of each cluster, I employed the Chromosome Conformation Capture (3C) technique on developing forebrain at E13.5 and E15.5. My 3C analysis provided potential enhancer-promoter interaction, in cis, that are consistent with previously known regulatory mechanisms. Furthermore, trans interactions may exist between Dlx1/Dlx2 and Dlx5/Dlx6 clusters in the developing forebrain at E13.5, thus providing a possible novel cross-regulatory mechanism between these two loci. I have also investigated the phenotypic consequences of Dlx enhancer deletion(s) on forebrain development by characterizing mice with I56ii and I56ii/I12b enhancer deletions. Enhancer deletions significantly impair Dlx expression as well as that of Evf2, Gad2 and of the striatal markers Islet1 and Meis2. Enhancer deletion(s) also reduce the expression of ISLET1 and CTIP2 proteins and Semaphorin 3A, Slit1 and Ephrin A5 that are thought to provide guidance cues in the corridor cells. Overall, these changes may disrupt the guidance of the thalamocortical axons. The data presented here further our understanding of the interactions between Dlx intergenic enhancers and promoter regions. Enhancer deletion(s) furthers our understanding of Dlx regulatory networks necessary that ensure proper Dlx expression, which, in turn may be involved in a genetic pathway underlying the synthesis of GABA, which may be further essential in maintaining the GABAergic phenotype.
Fiber and Prebiotic Interventions in Pediatric Inflammatory Bowel Disease: What Role Does the Gut Microbiome Play?
Creators: name: Healey, Genelle R.
name: Celiberto, Larissa S.
name: Lee, Soo Min
name: Jacobson, Kevan
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2020

description: The etiology of inflammatory bowel disease (IBD) is complex but is thought to be linked to an intricate interaction between the host’s immune system, resident gut microbiome and environment, i.e., diet. One dietary component that has a major impact on IBD risk and disease management is fiber. Fiber intakes in pediatric IBD patients are suboptimal and often lower than in children without IBD. Fiber also has a significant impact on beneficially shaping gut microbiota composition and functional capacity. The impact is likely to be particularly important in IBD patients, where various studies have demonstrated that an imbalance in the gut microbiome, referred to as dysbiosis, occurs. Microbiome-targeted therapeutics, such as fiber and prebiotics, have the potential to restore the balance in the gut microbiome and enhance host gut health and clinical outcomes. Indeed, studies in adult IBD patients demonstrate that fiber and prebiotics positively alter the microbiome and improve disease course. To date, no studies have been conducted to evaluate the therapeutic potential of fiber and prebiotics in pediatric IBD patients. Consequently, pediatric IBD specific studies that focus on the benefits of fiber and prebiotics on gut microbiome composition and functional capacity and disease outcomes are required.
title: Besser Hören: MHH-Hörzentrum bietet Patienten kurze Wege und eine optimierte Versorgung
Creators: name: Schweitzer, Arnd
Publisher: name: MHH
Year: 2003
Subjects: subject: 610

description: MHHinfo: Das Magazin der Medizinischen Hochschule Hannover, no. 3
Quelle formation donner aux traducteurs-postéditeurs de demain?
Creators: name: Saint-André, Louise
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: postédition
traduction automatique
formation en traduction

description: Certains affirment qu’à l’avenir, un nombre croissant de traducteurs postéditeront des textes issus de la traduction automatique plutôt que de traduire. Cette étude examine le bagage à inculquer aux futurs traducteurs-postéditeurs pour mieux les outiller. Un sondage mené en ligne auprès de postéditeurs du Canada et d’ailleurs montre que les compétences traductionnelles et rédactionnelles sont les plus utiles en PÉ, suivies des compétences en correction et d’aspects profession¬nels; les connais¬sances spécialisées et les compétences en informatique arrivent aux derniers rangs. Le sondage montre de plus que si les compétences traductionnel¬les et rédactionnel¬les sont généralement acquises pendant la formation universitaire en traduction, ce n’est pas le cas des compétences en correction, et encore moins des aspects professionnels : deux éléments à intégrer en priorité à la formation des traducteurs-postéditeurs pour la bonifier. La thèse propose deux formules susceptibles de favoriser l’intégration des éléments prioritaires pour mieux préparer les traducteurs-postéditeurs de demain.
The Influence of Weight Status on the Link between Television Viewing and Food Intake in Children
Creators: name: Borghese, Michael M.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Sedentary Behaviour
Screen Time
Childhood Obesity
Diet
Physical Activity
Television viewing
Observational Study
Cross-sectional Study

description: Recent research suggests that sedentary behaviours have detrimental effects on the health and well-being of children, including effects on obesity. Specifically, television viewing is consistently associated with childhood obesity. Two explanations have been proposed: 1) reduced energy expenditure, and 2) increased food intake. However, it has been suggested that the association between television viewing and childhood obesity may be better explained by an increase in energy intake than by a reduction in energy expenditure. To date, children of different weight status have not been compared in their dietary patterns in front of the television, and it is not known if total sedentary time is linked with food intake in children. The objectives of this thesis are: 1) to determine if obese children consume food more frequently while watching television than normal weight children, and 2) to examine which of television viewing or total sedentary time better predicts dietary patterns in children. Overall, our results re-affirm the notion that television viewing is associated with obesity, although physical activity plays a role in this association. Also, children who are obese consume fast food and fruits/vegetables more frequently during television watching than normal weight children. Furthermore, television viewing appears to be a better predictor of dietary patterns in children than overall sedentary time. Globally, these results provide evidence for the deleterious effects of television viewing on children’s dietary patterns and justification for future intervention studies designed to reduce television viewing in children with obesity.
Lay-up Moulding of a Carbon Fiber Reinforced Polymer Composite on a Cold Sprayed Metallic Layer
Creators: name: Archambault, Guillaume
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Carbon fiber reinforced composite
Cold gas dynamic spray
Copper
Invar
Lay-up moulding
Lightning
Low pressure cold spray
Metallized composite
Resistivity

description: The aerospace industry is incessantly investigating innovative techniques to increase aircraft fuel efficiency. As a consequence of innovative efforts, the cost of flying is continuously reduced and the aircraft’s mechanical performance improved. To achieve an important weight reduction, the fuselage of aircrafts like the Boeing 787 ‘‘Dreamliner’’ is mainly made of carbon fiber based composites. Having a high material specific strength-to-weight ratio, carbon fiber reinforced composites are state of the art materials in the aerospace industry. The in-flight concern of having the aircraft subjected to lightning is an ongoing safety issue. In the event of a lightning striking the fuselage, localized melting of the composite will commonly occur, as carbon fiber reinforced composites are highly resistive materials. A current design solution to prevent the fuselage from extended damaging/melting is to integrate an embedded metallic mesh between the carbon fiber composite plies. Upon lightning strike on the external skin of the composite material, the electrical current dissipates through the metallic mesh, thus minimizing damages of the composite part to localized melting. In addition to the integrated mesh, another solution to minimize/prevent localized melting of the composite is to rivet relatively thick and heavy metallic protective plates over the components prone to lightning such as the nose and wing tips of the aircraft. To resolve weight issues arising from heavy riveted plates, it would be advantageous to deposit thin layers of conductive material on the carbon fiber based composite surface. Unfortunately, high operating temperatures of conventional thermal spray processes used to apply a metallic overlay would degrade the carbon fiber based composites. For the purpose of producing metallic coated carbon fiber based composites, a new innovative technique which combines Cold Gas Dynamic Spray and lay-up moulding of composites is envisioned. This current study presents a detailed description of the experimental approach developed to produce metallic coated composites and demonstrates the manufacturability of such components at the commercial scale. Technical prerequisites, such as obtaining a low resistivity metallized composite and producing an easily removable metallic layer from the mould during lay-up moulding, are essential for the production of such aerospace materials. The thesis results obtained at the University of Ottawa Cold Spray Laboratory show that highly conductive and dense metallized composites could be produced.
title: Medizin in den Medien: Gesundheit ist präsent: in Zeitung, Hörfunk und Fernsehen
Creators: name: Schweitzer, Arnd
Publisher: name: MHH
Year: 2002
Subjects: subject: 610

description: MHHinfo: Das Magazin der Medizinischen Hochschule Hannover, no. 4
Overexpression of GbF3′5′H1 Provides a Potential to Improve the Content of Epicatechin and Gallocatechin
Creators: name: Wu, Yaqiong
name: Wang, Tongli (Forest Geneticist)
name: Xin, Yue
name: Wang, Guibin
name: Xu, Li-An
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2020

description: The flavonoids in Ginkgo biloba L. (ginkgo) have important medicinal uses due to their antioxidant, antitumor, and blood circulation-promoting effects. However, the genetic mechanisms underlying flavonoid biosynthesis in ginkgo remain elusive. Flavonoid 3′, 5′-hydroxylase (F3′5′H) is an important enzyme in flavonoid synthesis. We detected a novel differentially expressed GbF3′5′H1 gene homologous to the F3′5′H enzyme involved in the flavonoid synthesis pathway through transcriptome sequencing. In this study, we characterized this gene, performed an expression analysis, and heterologously overexpressed GbF3′5′H1 in Populus. Our results showed that GbF3′5′H1 is abundant in the leaf and highly expressed during April. We also found four metabolites closely related to flavonoid biosynthesis. Importantly, the contents of 4′,5-dihydroxy-7-glucosyloxyflavanone, epicatechin, and gallocatechin were significantly higher in transgenic plants than in nontransgenic plants. Our findings revealed that the GbF3′5′H1 gene functions in the biosynthesis of flavonoid-related metabolites, suggesting that GbF3′5′H1 represents a prime candidate for future studies (e.g., gene-editing) aiming to optimize ginkgo flavonoid production, especially that of flavan-3-ols.
Assessment and Analysis of the Restriction of Retroviral Infection by the Murine APOBEC3 Protein
Creators: name: Aydin, Halil Ibrahim
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: Retrovirus
MLV
APOBEC3
Gammaretrovirus
Innate Immunity
Intrinsic Immunity
Deamination

description: Human APOBEC3 proteins are host-encoded intrinsic restriction factors that can prevent the replication of a broad range of human and animal retroviruses such as HIV, SIV, FIV, MLVs and XMRV. The main pathway of the restriction is believed to occur as a result of the cytidine deaminase activity of these proteins that converts cytidines into uridines in single-stranded DNA retroviral replication intermediates. Uridines in these DNA intermediates disrupt the viral replication cycle and also alter retrovirus infectivity because of the C-to-T transition mutations generated as a result of the deaminase activity on the minus strand DNA. In addition, human APOBEC3 proteins also exhibit a deamination-independent pathway to restrict retroviruses that is not currently well understood. Although the restriction of retroviruses by human APOBEC3 proteins has been intensely studied in vitro, our understanding of how the murine APOBEC3 (mA3) protein restricts retroviruses and/or prevents zoonotic infections in vivo is very limited. In contrast to humans and primates that have 7 APOBEC3 genes, mice have but a single copy. My study of the function and structure of mA3 revealed that it has an inverted functional organization for cytidine deamination in comparison to the human A3G catalytic sites. I have also found that disruption of the integrity of either of these catalytic sites substantially impedes restriction of HIV and MLV. Interestingly, our data shows that mA3 induces a significant decrease in retroviral activity of HIV and MLVs by exploiting both deamination-dependent and -independent pathways. However, the deaminase activity of mA3 is essential to confer long-term restriction of retroviral infection. My observations suggest that mA3 has dual activities, both deamination-dependent and -independent, that work cooperatively to restrict a broad range of human and animal retroviral pathogens. In the context of the intrinsic immune system, APOBEC3 proteins provide a powerful block to the transmission of retroviral pathogens that very few have found ways to evade.
Improving Pretrained YAMNet for Enhanced Speech Command Detection via Transfer Learning
Creators: name: Lachenani, Sidahmed
name: Kheddar, Hamza
name: Ouldzmirli, Mohamed
Publisher: name: arXiv
Year: 2025
Subjects: subject: Sound (cs.SD)
subject: Artificial Intelligence (cs.AI)
subject: Audio and Speech Processing (eess.AS)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: This work addresses the need for enhanced accuracy and efficiency in speech command recognition systems, a critical component for improving user interaction in various smart applications. Leveraging the robust pretrained YAMNet model and transfer learning, this study develops a method that significantly improves speech command recognition. We adapt and train a YAMNet deep learning model to effectively detect and interpret speech commands from audio signals. Using the extensively annotated Speech Commands dataset (speech_commands_v0.01), our approach demonstrates the practical application of transfer learning to accurately recognize a predefined set of speech commands. The dataset is meticulously augmented, and features are strategically extracted to boost model performance. As a result, the final model achieved a recognition accuracy of 95.28%, underscoring the impact of advanced machine learning techniques on speech command recognition. This achievement marks substantial progress in audio processing technologies and establishes a new benchmark for future research in the field.
Computational Investigations of Noise-mediated Cell Population Dynamics
Creators: name: Charlebois, Daniel
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: biophysics
gene expression
gene regulatory network
drug resistance
stochastic simulation algorithm
noise
cellular population dynamics
epigenetics and evolution

description: Fluctuations, or "noise", can play a key role in determining the behaviour of living systems. The molecular-level fluctuations that occur in genetic networks are of particular importance. Here, noisy gene expression can result in genetically identical cells displaying significant variation in phenotype, even in identical environments. This variation can act as a basis for natural selection and provide a fitness benefit to cell populations under stress. This thesis focuses on the development of new conceptual knowledge about how gene expression noise and gene network topology influence drug resistance, as well as new simulation techniques to better understand cell population dynamics. Network topology may at first seem disconnected from expression noise, but genes in a network regulate each other through their expression products. The topology of a genetic network can thus amplify or attenuate noisy inputs from the environment and influence the expression characteristics of genes serving as outputs to the network. The main body of the thesis consists of five chapters: 1. A published review article on the physical basis of cellular individuality. 2. A published article presenting a novel method for simulating the dynamics of cell populations. 3. A chapter on modeling and simulating replicative aging and competition using an object-oriented framework. 4. A published research article establishing that noise in gene expression can facilitate adaptation and drug resistance independent of mutation. 5. An article submitted for publication demonstrating that gene network topology can affect the development of drug resistance. These chapters are preceded by a comprehensive introduction that covers essential concepts and theories relevant to the work presented.
Development of the Domino Pericyclic Oxy-Cope/Ene /Claisen /Diels-Alder Reaction and the Synthesis of Complex Bicyclo[3.3.1]alkenones
Creators: name: Sow, Boubacar
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: PPAP
Domino
Organic synthesis
Gold catalysis
Sesquichloride

description: This thesis is a dissertation to support the development of new domino pericyclic oxy-Cope/ene/Claisen/Diels-Alder reaction, diversity oriented synthesis of PPAPs scaffold via sequential one pot cascade reaction and ethyl aluminum sesquichloride catalyzed highly hindered Diels-Alder reaction. The first part concentrates on the domino pericyclic oxy-Cope/ene/Claisen/Diels-Alder reaction. As a result of this study, we have developed a general methodology for rapidly constructing complex diterpenes and discovered a thermal oxy-Cope/ene/Claisen/Claisen rearrangement, applied to the synthesis of trans decalin benzofurans. The second part involved the development of an efficient synthetic approach towards bicyclo[3.3.1]nonenone core found in many natural products, via a sequential Diels-Alder/gold(I)-catalyzed 6-endo-dig cyclization and its application to the synthesis of a diversified library of PPAPs. Finally, we have developed an efficient synthetic methodology for the formation of cyclohexene rings bearing quaternary carbon centers via an ethyl aluminum sesquichloride mediated highly hindered Diels-Alder reaction. This method solved an important problem encountered in the synthesis of many natural products including PPAPs. This methodology opened new opportunities in the total synthesis of PPAPs.
The Word Feel as a Linguistic Device in Self-disclosure and Enacted Social Support
Creators: name: Doell, Kelly G.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: social support
self-disclosure
Foucault

description: The purpose of this research is to explore how people make sense of the word feel in their communication across different social relationships and contexts. Assuming the use of the word feel is linked to the act of emotional expression, a secondary purpose is to examine how the perceived management of the word feel may be linked to well-being. Fifteen individual participants shared their perceptions about how they use the word feel over eight types of interpersonal relationships. Discourse analysis revealed that the function of the word feel was to self-disclose emotions or to inquire about them in others. The word feel emerged as a tool that can be wielded to achieve catharsis, intimacy, or social support while framing several subject positions within a discourse of emotional disclosure. When the word feel was reciprocated with others, participant perceptions showed how social status influenced how it was managed in relationships. In particular, the vulnerable disclosing parties were required to take risks in order to achieve the benefits of disclosure. Ruptures in the discourse occurred when participants who did not have opportunities to self-disclose experienced an unwanted emotional tension, an interest in receiving social support, or a drive to find closeness. These instances led to a use of the word feel outside of its emergent social rules. Finally, the beliefs of participants showed it was not just status that played a role in its management but gender as well. The findings show that although the deployment of feel requires judicious management of the risks inherent in emotional self-disclosure, the use of this can indicate the exchange of social resources known to have positive effects on well-being.
Stratified wakes of a prolate spheroid at moderate angle of attack
Creators: name: Nidhan, Sheel
name: Jain, Sanidhya
name: Ortiz-Tarin, Jose L.
name: Sarkar, Sutanu
Publisher: name: arXiv
Year: 2025
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: Ocean submersibles and aerial vehicles often encounter a density-stratified environment whose effect on flow features is of interest. A 6:1 prolate spheroid of diameter $D$ with velocity $U$ and at a moderate angle of attack (AOA) of $10^\circ$ is taken as a canonical example of a submersible. Buoyancy effects are examined in a parametric LES study of the spheroid wake at $Re = UD/ν= 5000$ where stratification is changed to cover a wide range of values of body Froude number ($Fr = U/ND$). The Froude number measures buoyancy time scale (1/$N$ where $N$ is the buoyancy frequency) relative to flow time scale ($D/U$). The simulated cases range from a baseline case without stratification, i.e. $Fr = \infty$, to the substantial stratification level of $Fr = 1$. The very near wake, just two body diameters aft of the trailing edge, is found to be substantially altered at even the relatively weak stratification of $Fr = 6$. Specifically, the coherence of the streamwise vortex pair shed from the body is weakened, the downward trajectory of the wake center is suppressed, and the mean/turbulence structure changes in the near wake. Diagnosis of the vorticity transport equation reveals that the baroclinic torque becomes an important contributor to the balance of mean streamwise vorticity in the very near wake at $Fr = 6$. With increasing stratification, the wake topology changes significantly, e.g. the $Fr =1$ case exhibits a secondary wake above the primary wake.
description: 6 pages, 6 figures
The Structural Characterization of Two Prokaryotic Membrane Proteins: CfrA and ELIC
Creators: name: Carswell, Casey
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Membrane Protein
Campylobacter jejuni
Crystallization
FTIR
TonB Dependent Transporter
CfrA
ELIC
Pentameric Ligand Gated Ion Channels
Uncoupling
structural characterization
lipid sensitivity
coupling
aromatics
Intramembrane aromatics

description: This thesis focuses on the structural and functional characterization of two integral membrane proteins; CfrA, an outer membrane TonB-dependent transporter (TBDT) from Campylobacter jejuni, and ELIC, a pentameric ligand-gated ion channel (pLGIC) from Erwinia Chrysanthemi. The spectroscopic characterization of CfrA revealed a fold consistent with the structural and biophysical properties observed for other TBDT. Both a homology model of CfrA and sequence alignments of CfrA with other ferric-enterobactin transporters suggested a unique mode of ligand binding, thus raising the possibility that C. jejuni can be specifically inhibited. To investigate the molecular determinates of binding to CfrA, I set out to crystallize CfrA. Hundreds of crystal trials led to crystals diffracting to 3.6 Å resolution, with a complete data set acquired at 5 Å resolution that led to a structural model of the CfrA β-barrel. In the second part of this thesis, I reconstituted ELIC into model membranes in order to test the role of intramembrane aromatic interactions in ELIC gating and lipid sensing. ELIC was reconstituted into both asolectin (aso-ELIC) and 1-palmitoyl-2-oleoyl phosphatidylcholine (PC-ELIC), membranes that stabilize the homologous nicotinic acetylcholine receptor (nAChR) in functional coupled versus non-functional uncoupled conformations, respectively. In both membrane environments, ELIC exhibits a mixed α-helical and β-sheet secondary structure, with a thermal denaturation intermediate between those of the nAChR and the close prokaryotic homolog, GLIC, in similar membranes. The data suggest that although ELIC has a decreased propensity to adopt an uncoupled conformation relative to the nAChR, its ability to undergo cysteamine-induced channel gating is sensitive to its lipid environment. The decreased propensity to uncouple may reflect an increased level of aromatics at the interface between the transmembrane α-helices, M1, M3, and M4. To test this hypothesis further, the level or aromatic residues at the M1, M3, and M4 interface in both GLIC and ELIC were varied, and in both cases the levels of intramembrane aromatic interactions correlated with the efficiency of coupling binding to gating. The data provide further evidence for a role of intramembrane aromatics in channel gating and in dictating the propensity of pentameric ligand-gated ion channels to adopt an uncoupled conformation.
Beyond Productivity: Rethinking the Impact of Creativity Support Tools
Creators: name: Cox, Samuel Rhys
name: Djernæs, Helena Bøjer
name: van Berkel, Niels
Publisher: name: arXiv
Year: 2025
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: Multimedia (cs.MM)
subject: FOS: Computer and information sciences

description: Creativity Support Tools (CSTs) are widely used across diverse creative domains, with generative AI recently increasing the abilities of CSTs. To better understand how the success of CSTs is determined in the literature, we conducted a review of outcome measures used in CST evaluations. Drawing from (n=173) CST evaluations in the ACM Digital Library, we identified the metrics commonly employed to assess user interactions with CSTs. Our findings reveal prevailing trends in current evaluation practices, while exposing underexplored measures that could broaden the scope of future research. Based on these results, we argue for a more holistic approach to evaluating CSTs, encouraging the HCI community to consider not only user experience and the quality of the generated output, but also user-centric aspects such as self-reflection and well-being as critical dimensions of assessment. We also highlight a need for validated measures specifically suited to the evaluation of generative AI in CSTs.
description: In ACM Creativity and Cognition (C&C '25), June 23-25, 2025; 15 pages; 2 Figures; 3 Tables
Communautés d’apprentissage professionnelles : conditions d’implantation mises en place par deux directrices d’école élémentaire
Creators: name: Génier, Éric
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: CAP
PLC
Ontario
École
School
Ministère

description: La présente recherche tente d’identifier et de décrire les conditions d’implantation qui ont été mises en place dans deux écoles élémentaires francophones de l’Ontario pour atteindre un stade de fonctionnement avancé, soit l’intégration (Leclerc, Moreau et Lépine, 2009a) des communautés d’apprentissage professionnelles (CAP). En utilisant un échantillon de directions d’école et d’enseignants qui travaillent à l’intérieur d’écoles où les CAP sont à un tel stade de fonctionnement, notre recherche a permis de relever quelles conditions ont été mises en place pour atteindre un fonctionnement avancé des CAP. Des entrevues semi-dirigées ont été menées auprès de deux directrices et de quatre enseignantes d’écoles élémentaires franco-ontariennes. Ces entrevues abordaient de grands thèmes tels que la structure des CAP, la culture de collaboration et les processus employés en CAP dans le contexte de l’école. Un questionnaire sur le sentiment d’efficacité personnelle fut aussi rempli par les directrices d’école. Les résultats mettent en évidence le rôle complexe de la direction d’école dans la mise en œuvre des CAP tout en précisant les conditions d’implantation des CAP mises de l’avant par deux directrices d’école. En fait, nous relevons l’importance de recevoir des appuis humains et financiers et un soutien par la recherche; d’instaurer des exigences organisationnelles « préparatoires »; de respecter des exigences organisationnelles de mise en place des CAP; d’assurer que la direction et les membres du conseil scolaire aient confiance et soient compétents; d’instaurer un leadership partagé entre la direction, le conseil scolaire et les enseignants du comité d’amélioration du rendement des élèves (CARE); de rédiger des objectifs SMART à partir de ressources particulières et aménager un parcours de fonctionnement; d’établir des structures physiques et d’encourager une culture de collaboration entre les enseignants. Les résultats de notre étude rejoignent ce qu’avancent les recherches au sujet de l’implantation de la structure organisationnelle – CAP – dans une école. Or, notre recherche sur le terrain permet d’apporter des précisions quant à ces conditions d’implantation. D’ailleurs, nous avons recensé certaines sous-catégories thématiques qui ne sont pas reflétées explicitement dans la littérature.
Szenarienstudie für das Abflussregime des Rheins
Creators: name: Moser, Hans
name: Nilson, Enno
Publisher: name: Bundesanstalt für Gewässerkunde
Year: 2013
Subjects: KLIWAS, Klimawandel, Hochwasser, Mittelwasser, Niedrigwasser, Rhein, IKSR

description: Szenarienstudie für das Abflussregime des Rheins
Politique et guerre dans l'oeuvre de Raymond Aron
Creators: name: Messier, Francois
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Aron
Politique
Guerre
Idéalisme
Réalisme
Républicanisme
Libéralisme
Clausewitz
Relations internationales
État

description: « La guerre est simplement la poursuite de la politique par d’autres moyens » : c’est la formule la plus célèbre de Clausewitz. Veut-elle dire que la guerre est un instrument du politique, un de ses moyens, comme le soutiennent certains ? Ou plutôt, comme le soutiennent d’autres, veut-elle dire que la guerre doit, par nécessité, être soumise au politique afin d’en contenir les débordements ? La réponse tient, c’est l’hypothèse principale qui se situe au cœur de ce travail, dans la conception aronienne du politique qui unit une forme de réalisme politique (les rapports entre les hommes et les sociétés sont fondés sur les conflits d’intérêts et d’idées, sur la puissance et la force) et une forme d’idéalisme à consonance kantienne (par-delà la puissance et la force, la raison demeure une fin ou un idéal régulateur qui demeure à l’horizon de la coexistence des êtres humains). Si, pour Aron, la guerre est inévitable, elle n’abolit pas –sauf les cas où elle devient « totale » – le politique car, selon lui, elle n’occupe pas tout l’espace. Le primat du politique est donc réaffirmé même en situation de guerre. Mais plutôt qu’une véritable « continuation » de la politique par la guerre, faisant de celle-ci un instrument de celui-là, il faudrait envisager ici une autre manière d’affirmer ce primat, fondé sur une sorte de « lien de nécessité » : l’inévitable phénomène qu’est la guerre ne peut être laissé à lui-même, il doit nécessairement être encadré par le politique afin d’éviter tout débordement. Toutefois, cet encadrement n’offre aucune garantie et, à la fin, cette absence de garantie, qui n’a rien à voir avec un scepticisme désespéré, propose un pari sur une raison incertaine mais résiliente : «si nous ne parions pas sur la raison, sur quoi allons-nous parier ? »
PERCEIVED INFLUENCE OF LECTURER-STUDENTS' RELATIONSHIP ON THE ACADEMIC PERFORMANCE OF STUDENTS IN PUBLIC UNIVERSITIES IN ANMABRA STATE
Creators: name: Onyekwelu, Raphael Azubuike, PhD
name: Helen Chinelo, Onuorah, PhD.
Publisher: name: ZAP Journal
Year: 2024
Subjects: Influence, Lecturer-Students Relationship, Academic Performance, Students, Universities

description: The main purpose of the study was to determine the perceived influence of lecturer-students’ relationship on the academic performance of students in public universities Anambra State. Two research questions and one hypothesis guided the study. The descriptive survey design was adopted for the study. The population of the study comprised 212 (400 level) students of Educational Management and Policy and Educational Foundations Department in the 2023/2024 academic session in Public universities in Anambra State and Chukwuemeka Odumegwu Ojukwu University, Igbariam Campus. The entire population was used without sampling because it was manageable. Two questionnaires were used to collect data for the study. The instruments were validated and their reliability test conducted. Mean, standard deviation and t-test were used to analyze data for the study. The findings of the study revealed that open and consistent communication between lecturer and students influence academic achievement of students in public universities in Anambra State to a high extent. The finding of the study also revealed that mutual trust and respect between lecturer and students influence academic achievement of students in Public universities in Anambra State to a high extent. Furthermore, the finding of the study revealed that lecturer-students’ relationship significantly influences students academic performance in public universities in Anambra State. Based on these findings, the researcher recommended among others that administrators of public universities should prioritize initiatives aimed at fostering open and consistent communication between lecturers and students by implementing regular feedback mechanisms, establishing clear communication protocols and providing training for lecturers on effective communication strategies
Enhancing Load Balancing Efficiency Based on Migration Delay for Distributed Virtual Simulations
Creators: name: Alghamdi, Turki
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Distributed simulations
High Level Architecture
Load Balancing
Performance

description: Load management is an essential and important factor for distributed simulations running on shared resources due to load imbalances that can caused considerable performance loss. High Level Architecture (HLA) -based simulation is a framework that works to facilitate the design and management of distributed simulations. HLA coordinates the interaction between simulation entities (federates). However, HLA-based simulation standards do not present the ability to manage resources or help detect load imbalances that could directly cause decrease of performance. Focusing on this constraint, a migration-aware dynamic balancing system has been designed for HLA simulations to offer an efficient load-balancing scheme that works in large-scale environments. This system presents some limitations on estimating costs and benefits, so we propose an enhancement to this existing load balancing system, which improves the accuracy of estimating the number of migrations for the next load redistribution. The proposed scheme detects the load imbalances by evaluating the recourses overhead. The scheme classifies the recourses based on the overhead as overloaded and underloaded, followed by matching the highest overloaded recourses with the lowest underloaded recourses. Furthermore, the proposed scheme aims to precisely estimate the number of migrations by evaluating and analyzing the recourses to obtain the best number of migrations. Therefore, certain migrations that do not contribute to an improvement in the simulation performance are avoided. This avoidance is based on comparing time delay and time gain. Moreover, to be considered for migration, the overall sum of the time gains should be larger than the overall sum of the time delays. The proposed scheme has shown an improvement on decreasing the execution time.
Micro/nano-scale Manipulation of Material Properties
Creators: name: Farhana, Baset
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Laser material processing
Nanoscale fabrication
Femtosecond phenomena

description: Femtosecond laser interaction with dielectrics has unique characteristics for micromachining, notably non-thermal interaction with materials, precision and flexibility. The nature of this interaction is highly nonlinear due to multiphoton ionization, so the laser energy can be nonlinearly absorbed by the material, leading to permanent change in the material properties in a localized region of Mu-m3. This dissertation demonstrated the potential of these nonlinear interactions induced changes (index modification and ablation for machining) in the dielectrics and explored several practical applications. We studied femtosecond laser ablation of Poly-methayl methacrylate (PMMA) under single and multiple pulse irradiation regimes. We demonstrated that the onset of surface ablation in dielectric surface is associated with surface swelling, followed by material removal. Also, the shape of the ablation craters becomes polarization dependent with increasing fluence, except for circular polarization. The morphology of the damaged/ablated material was examined by optical and scanning electron microscopy. The dynamics of laser ablation of PMMA was simulated using a 2 dimensional Molecular Dynamics model and a 3 dimensional Finite Difference Time Domain model. The results from numerical simulations agreed well with experimental results presented in this thesis. We also demonstrated the formation of nano-pillar within the ablation crater when the surface of bulk-PMMA was irradiated by two femtosecond pulses at a certain delay with energies below single shot ablation threshold. With increasing fluence, the nano-pillar vanished and the structure within the ablation crater resembled volcanic eruption. At higher fluences we demonstrated nanoscale porosity in PMMA. For application, a novel in-line fiber micro-cantilever was fabricated in bend insensitive fiber, that provides details of in-line measurement of frequency and amplitude of vibration, and can be further extended to be used as chemical/bio and temperature sensors. By modifying the refractive index at random spacing within the single mode fiber core, a unique quasi-random micro-cavities fiber laser was fabricated, which exhibits comparable characteristics with a commercial fiber laser in terms of narrow linewidth and frequency stability.
A counterexample regarding an equivalence relation on a product space
Creators: name: Shani, Assaf
Publisher: name: arXiv
Year: 2025
Subjects: subject: Logic (math.LO)
subject: FOS: Mathematics
subject: 03E15

description: We present a counterexample to Conjecture~14.1.6 from [Vladimir Kanovei, Borel equivalence relations], regarding Borel equivalence relations on product spaces.
Contributors to Optimal Sexual Experiences
Creators: name: Ménard, Amy D.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Sexual pleasure
Great sex
Peak experiences
Eroticism
Optimal sexual intimacy

description: The purpose of this research was to identify the contributors to optimal sexual experiences. At present, there is a lack of clinical knowledge, research knowledge and in-depth public discourse concerning the nature of healthy sexuality. The theoretical and research literature in this area has focused almost exclusively on defining and conceptualizing sexual dysfunctions with little attention paid to either normal or satisfactory experiences. Very little theory exists on the nature and components of optimal sexuality. To date, no empirical investigations have been done to determine the contributors to optimal sexual experiences. In order to identify the contributors to optimal sexual experiences, semi-structured interviews were conducted with 12 individuals who reported having experienced “great sex”. A phenomenologically-oriented content analysis was performed on interview transcripts to determine the contributors to optimal sexual experiences. Analysis led to the identification of seven major contributors, two pathways towards optimal sexual experiences and two minor contributors. The major contributors included developmental contributors, individual qualities overall, individual qualities in-the moment, skills, relationship qualities overall, relationship qualities in-the-moment and environmental, situational and preparatory contributors. Each of these larger themes was also characterized by a variety of more specific themes. The two pathways that led to optimal sexual experiences included individual qualities that facilitated relationship qualities and relationship qualities that facilitated individual qualities. Finally, the minor contributors consisted of personal proclivities and miscellaneous contributors. Noteworthy findings of this investigation are discussed and then compared and contrasted with existing research and theory. The implications of this work for the general public, sex therapy, sex education, theory and research are considered as well as the strengths and limitations of this study.
title: Wie spiegelt sich die Psychiatriereform der letzten 50 Jahre in der Zeitschrift »Sozialpsychiatrische Informationen«?
Creators: name: Elgeti, Hermann
Publisher: name: Medizinische Hochschule Hannover Bibliothek
Year: 2021
Subjects: subject: 610

description: Sozialpsychiatrische Informationen, vol. 51, no. 1, p. 7
Oral beta-lactam step down in bacteremic E. coli urinary tract infections
Creators: name: Saad, Stephan
name: Mina, Neil
name: Lee, Colin
name: Afra, Kevin
Publisher: name: BioMed Central
Year: 2020

description: Background: Literature is scarce regarding oral step down to beta-lactams in bacteremic urinary tract infections. Oral fluoroquinolones are an accepted and common step down for bacteremic urinary tract infections; however, their use is associated with mounting safety concerns. We compared clinical cure in patients with E. coli bacteremic urinary tract infections who were stepped down to oral beta-lactams compared to oral fluoroquinolones. Methods: This multicentre retrospective cohort study included patients with first positive concurrent urine and blood cultures from January 2016 to December 2016. Patients were included if they received empiric intravenous beta-lactam therapy with step down to either oral beta-lactam or fluoroquinolone for treatment completion. The primary outcome was clinical cure. Secondary outcomes were length of hospitalization, all-cause mortality and C. difficile infection. Multivariate analysis and propensity score were used to control for confounding. Results: A total of 207 patients were identified with bacteremic E.coli urinary tract infections. Clinical cure was achieved in 72/77 (94%) in the oral beta-lactam group versus 127/130 (98%) in the oral fluoroquinolone group (absolute difference − 4.2, 95% confidence interval [CI] -10.3 to 1.9%, p = 0.13). The adjusted odds ratio (OR) for clinical cure with oral beta-lactams was 0.31 (95% CI 0.05–1.90, p = 0.21); propensity score adjusted analysis showed a similar result. There was no statistically significant difference in secondary outcomes. Conclusions: Oral beta-lactams appear to be a safe and effective step down option in bacteremic E. coli urinary tract infections compared to oral fluoroquinolones.