New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Creators: name: Global BPgen Consrotium
name: Sovio, Ulla
name: Shuldiner, Alan R.
name: Dedoussis, George V.
name: Bonnycastle, Lori L.
name: Hercberg, Serge
name: Chen, Yii-Der Ida
name: Visvikis-Siest, Sophie
name: Kumari, Meena
name: Meneton, Pierre
name: Ariyurek, Yavuz
name: Egan, Josephine M.
name: Ben-Shlomo, Yoav
name: Forouhi, Nita G.
name: Graessler, Jurgen
name: Rudan, Igor
name: Pedersen, Nancy L.
name: Lindgren, Cecilia M.
name: Chines, Peter
name: Stringham, Heather M.
name: Meisinger, Christa
name: Pattaro, Cristian
name: Vogelzangs, Nicole
name: DIAGRAM Consortium
name: Illig, Thomas
name: Langenberg, Claudia
name: Zethelius, Bjorn
name: Sayer, Avan Aihie
name: Laakso, Markku
name: Li, Man
name: Clarke, Robert
name: Isomaa, Bo
name: McAteer, Jarred B.
name: Doney, Alex
name: Pedersen, Oluf
name: Jorgensen, Torben
name: Bottcher, Yvonne
name: Ebrahim, Shah
name: Schwarz, Peter
name: Lecoeur, Cecile
name: Psaty, Bruce M.
name: Shrader, Peter
name: Knight, Beatrice
name: Beilby, John P.
name: Gieger, Christian
name: Ripatti, Samuli
name: Zhao, Jing Hua
name: Herder, Christian
name: Morken, Mario A.
name: Kesaniemi, Y. Antero
name: Orru, Marco
name: Mitchell, Braxton D.
name: Thorand, Barbara
name: Lyssenko, Valeriya
name: Manning, Alisa K.
name: Sethupathy, Praveen
name: Meyre, David
name: Hansen, Torben
name: Rayner, Nigel W.
name: Hammond, Naomi
name: Timpson, Nicholas J.
name: Sanna, Serena
name: Brunner, Eric
name: Zhai, Guangju
name: Witteman, Jacqueline C.M.
name: Rybin, Denis
name: Cornelis, Marilyn
name: Zabena, Carina
name: Willemson, Gonneke
name: Kaakinen, Marika
name: Perry, John R.B.
name: Zelenika, Diana
name: Walters, G. Bragi
name: Heath, Simon C.
name: Oostra, Ben A.
name: Salomaa, Veikko
name: Ward, Kim L.
name: van Dijk, Ko Willems
name: Williams, Gordon H.
name: Karpe, Fredrik
name: Wagner, Peter J.
name: Magi, Reedik
name: Fischer-Rosinsky, Antje
name: Hallmans, Goran
name: Lajunen, Taina
name: Qi, Lu
name: Navarro, Paul
name: Grallert, Harald
name: Pramstaller, Peter Paul
name: Kaprio, Jaakko
name: Smith, Nicholas L.
name: Hayward, Caroline
name: Sandbaek, Annelli
name: Sparso, Thomas
name: Dina, Christian
name: Paolisso, Giuseppe
name: Wright, Alan F.
name: Mangino, Massimo
name: Henneman, Peter
name: Smith, George Davey
name: Boerwinkle, Eric
name: Prokopenko, Inga
name: Jackson, Anne U.
name: Grarup, Niels
name: Walley, Andrew
name: Hofman, Albert
name: Hadjadj, Samy
name: Hu, Frank B.
name: Hung, Joe
name: Li, Yun
name: Gwilliam, Rhian
name: Thorleifsson, Gudmar
name: Singleton, Andrew
name: Ardlie, Kristin
name: Kivimaki, Mika
name: Syvanen, Ann-Christine
name: Zillikens, M. Carola
name: Day, Ian N.M.
name: Rice, Kenneth
name: Silander, Kaisa
name: Bergmann, Sven
name: Simpson, Laila
name: Scott, Laura J.
name: Melzer, David
name: Neville, Matthew J.
name: Watkins, Hugh
name: Ingelsson, Erik
name: Lathrop, G. Mark
name: Scheet, Paul
name: Hottenga, Jouke Jan
name: Song, Kijoung
name: Benediktsson, Rafn
name: de Geus, Eco J. C.
name: Le Bacquer, Olivier
name: Hillman, David R.
name: Koskinen, Seppo
name: Frants, Rune
name: Lind, Lars
name: Kanoni, Stavroula
name: Sandhu, Manjinder
name: Crawford, Gabe
name: Sigurdsson, Gunnar
name: Pfeiffer, Andreas F.H.
name: Pattou, Francois
name: Pankow, James S.
name: Wilson, James F.
name: Bennett, Amanda J.
name: Dupuis, Josee
name: Potter, Simon C.
name: Elliott, Amanda
name: Province, Michael A.
name: Perola, Markus
name: Serrano-Rios, Manuel
name: Kyvik, Kirsten Ohm
name: Yarnell, John W.G.
name: Pakyz, Ruth
name: Johnson, Paul R.V.
name: Borch-Johnsen, Knut
name: Saxena, Richa
name: Steinthorsdottir, Valgerdur
name: Tanaka, Toshiko
name: Campbell, Harry
name: Barter, Philip
name: Franzosi, Maria Grazia
name: GIANT Consortium
name: Han, Xijing
name: Cavalcanti-Proenca, Christine
name: Glazer, Nicole L.
name: Kovacs, Peter
name: Stumvoll, Michael
name: Syddall, Holly
name: Hingorani, Aroon D.
name: Morris, Andrew P.
name: O'Connell, Jeffrey
name: Payne, Felicity
name: Galan, Pilar
name: Rivadeneira, Fernando
name: Wild, Sarah H.
name: McPherson, Ruth
name: Sijbrands, Eric J.G.
name: Hicks, Andrew A.
name: Dehghan, Abbas
name: Elliott, Paul
name: Cooper, Matthew N.
name: Sharp, Stephen J.
name: Balkau, Beverley
name: Voight, Benjamin F.
name: Roden, Michael
name: Tuomi, Tiinamaija
name: Franklin, Christopher S.
name: Swift, Amy
name: Pichler, Irene
name: Narisu, Narisu
name: Goodarzi, Mark O.
name: Franks, Paul W.
name: An, Ping
name: Bumpstead, Suzannah J.
name: Bochud, Murielle
name: Rathmann, Wolfgang
name: Randall, Joshua
name: Bouatia-Naji, Nabila
name: von Hoek, Mandy
name: Kuusisto, Johanna
name: Sampson, Michael J.
name: Wichmann, H. Erich
name: Vitart, Veronique
name: Tichet, Jean
name: Spranger, Joachim
name: Fedson, Annette C.
name: Waeber, Gerard
name: Wheeler, Eleanor
name: Polasek, Ozren
name: Coin, Lachlan J.M.
name: Varma, Dhiraj
name: Pearson, Daniel
name: Hartikainen, Anna-Liisa
name: Loos, Ruth J.F.
name: Grundy, Scott
name: Martinez-Larrad, Maria Teresa
name: Jula, Antti
name: Palmer, Colin N.A.
name: Mukherjee, Sutapa
name: Bornstein, Stefan R.
name: Gyllensten, Ulf
name: Roccasecca, Rosa Maria
name: Johnson, Toby
name: Crisponi, Laura
name: Weedon, Michael N.
name: Hamsten, Anders
name: Bonnefond, Amelie
name: Nathan, David M.
name: Silveira, Angela
name: Borecki, Ingrid B.
name: Hassanali, Neelam
name: Pouta, Anneli
name: Fox, Caroline S.
name: Cooper, Cyrus
name: McCulloch, Laura J.
name: Hattersley, Andrew T.
name: Seedorf, Udo
name: Zeggini, Eleftheria
name: Lawlor, Debbie A.
name: Uitterlinden, Andre G.
name: Rocheleau, Ghislain
name: Kao, W.H. Linda
name: Goel, Anuj
name: Palmer, Lyel J.
name: Magnusson, Patrik K.E.
name: Shields, Beverley
name: Tonjes, Anke
name: Soranzo, Nicole
name: Groves, Christopher J.
name: Gloyn, Anna L.
name: Charpentier, Guillaume
name: Erdos, Michael R.
name: Posthuma, Danielle
name: Marmot, Michael
name: Morris, Andrew D.
name: Luan, Jian'an
name: Delplanque, Jerome
name: Naitza, Silvia
name: Mahley, Robert
name: McCarroll, Steven A.
name: Hui, Jennie
name: Rolandsson, Olov
name: Peden, John F.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 nondiabetic participants. Follow-up of 25 loci in up to 76,558 additional subjects identified 16 loci associated with fasting glucose and HOMA-B and two loci associated with fasting insulin and HOMA-IR. These include nine loci newly associated with fasting glucose (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and C2CD4B) and one influencing fasting insulin and HOMA-IR (near IGF1). We also demonstrated association of ADCY5, PROX1, GCK, GCKR and DGKB-TMEM195 with type 2 diabetes. Within these loci, likely biological candidate genes influence signal transduction, cell proliferation, development, glucose-sensing and circadian regulation. Our results demonstrate that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes.