cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Figure S7 from Comparative genomic analysis of the ‘psuedofungus’ Hyphochytrium catenoides
Creators: name: Leonard, Guy
name: Labarre, Aurélie
name: Milner, David S.
name: Monier, Adam
name: Soanes, Darren
name: Wideman, Jeremy G.
name: Maguire, Finlay
name: Stevens, Sam
name: Sain, Divya
name: Grau-Bove, Xavier
name: Arnau Sebe-Pedros
name: Stajich, Jason E.
name: Paszkiewicz, Konrad
name: Brown, Matthew W.
name: Hall, Neil
name: Wickstead, Bill
name: Richards, Thomas A.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 60408 Genomics
subject: FOS: Biological sciences

description: Eukaryotic microbes have three primary mechanisms for obtaining nutrients and energy: phagotrophy, photosynthesis and osmotrophy. Traits associated with the latter two functions arose independently multiple times in the eukaryotes. Fungi successfully coupled osmotrophy with filamentous growth, similar traits are also manifested in the Pseudofungi (oomycetes and hyphochytriomycetes). Both the Fungi and the Pseudofungi encompass a diversity of plant and animal parasites. Genome-sequencing efforts have focused on host-associated microbes (mutualistic symbionts or parasites), providing limited comparisons with free-living relatives. Here we report the first draft genome sequence of a hyphochytriomycete ‘pseudofungus’; Hyphochytrium catenoides. Using phylogenomic approaches, we identify genes of recent viral ancestry, with related viral derived genes also present on the genomes of oomycetes, suggesting a complex history of viral coevolution and integration across the Pseudofungi. H. catenoides has a complex life cycle involving diverse filamentous structures and a flagellated zoospore with a single anterior-tinselate flagellum. We use genome comparisons, drug sensitivity analysis and high-throughput culture arrays to investigate the ancestry of oomycete/pseudofungal characteristics and metabolic traits, demonstrating that many of the genetic features associated with pathogenic traits evolved specifically within the oomycete radiation. Comparative genomics also identified differences in the repertoire of genes associated with filamentous growth between the Fungi and the Pseudofungi, including differences in vesicle trafficking systems, cell-wall synthesis pathways and motor protein repertoire, demonstrating that unique cellular systems underpinned the convergent evolution of filamentous osmotrophic growth in these two eukaryotic groups.
In vivo roles for Arp2/3 in cortical actin organization during C. elegans gastrulation
Creators: name: Roh-Johnson, Minna
name: Goldstein, Bob
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The Arp2/3 complex is important for morphogenesis in various developmental systems, but specific in vivo roles for this complex in cells that move during morphogenesis are not well understood. We have examined cellular roles for Arp2/3 in the Caenorhabditis elegans embryo. In C. elegans, the first morphogenetic movement, gastrulation, is initiated by the internalization of two endodermal precursor cells. These cells undergo a myosin-dependent apical constriction, pulling a ring of six neighboring cells into a gap left behind on the ventral surface of the embryo. In agreement with a previous report, we found that in Arp2/3-depleted C. elegans embryos, membrane blebs form and the endodermal precursor cells fail to fully internalize. We show that these cells are normal with respect to several key requirements for gastrulation: cell cycle timing, cell fate, apicobasal cell polarity and apical accumulation and activation of myosin-II. To further understand the function of Arp2/3 in gastrulation, we examined F-actin dynamics in wild-type embryos. We found that three of the six neighboring cells extend short, dynamic F-actin-rich processes at their apical borders with the internalizing cells. These processes failed to form in embryos that were depleted of Arp2/3 or the apical protein PAR-3. Our results identify an in vivo role for Arp2/3 in the formation of subcellular structures during morphogenesis. The results also suggest a new layer to the model of C. elegans gastrulation: in addition to apical constriction, internalization of the endoderm might involve dynamic Arp2/3-dependent F-actin-rich extensions on one side of a ring of cells.
(2815) Emily May Lucy [Sayer]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Mobility: A Novel by Lydia Kiesling on Audiobook New
Creators: name: Goodman
Publisher: name: Zenodo
Year: 2024

description: Mobility: A Novel by Lydia Kiesling

 

 

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Mobility: A Novel

Lydia Kiesling

Page: 368

Format: pdf, ePub, mobi, fb2

ISBN: 9781638930563

Publisher: Zando

 

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“A masterpiece of misdirection.” —Geraldine Brooks “Mobility is a truly gripping coming-of-age story about navigating a world of corporate greed that’s both laugh-out-loud funny and politically incisive.” —Jon Favreau, Jon Lovett, and Tommy Vietor Bunny Glenn believes in climate change. But she also likes to get paid. The year is 1998. The Soviet Union is dissolved, the Cold War is over, and Bunny Glenn is a lonely American teenager in Azerbaijan with her Foreign Service family. Through Bunny’s bemused eyes, we watch global interests flock to her temporary backyard for Caspian oil and pipeline access, hearing rumbles of the expansion of the American security state and the buildup to the War on Terror. We follow Bunny from adolescence to middle age—from Baku to Athens to Houston—as her own ambition and desire for comfort lead her to a career in the oil industry, eventually returning to the scene of her youth, where slippery figures from the past reappear in an era of political and climate breakdown.  Propulsive and thought-provoking, empathetic yet pointed, Mobility is a story about class, power, politics, and desire told through the life of one woman—her social milieu, her romances, her unarticulated wants. Through Bunny’s life choices, Lydia Kiesling masterfully explores American forms of complicity and inertia, moving between the local and the global, the personal and the political, and using fiction’s singular power to illuminate a life shaped by its context.

Mobility in the Victorian Novel: Placing the Nation - Google Books ResultMobility: A Novel: Kiesling, LydiaCharlotte Mathieson · 2015 · ‎Literary CriticismIf it has typically been understood that the English novel at this time is concerned gender and mobility in George Eliot and Charlotte Brontë's fiction.Times of Mobility: Transnational Literature and Gender inAutonomous Vehicles and Future Mobility - 1st EditionUpward Mobility and the Common Good: Toward a LiteraryThe New Mobility Handbook: Rethinking How We GetTimes of MobilitySneak Peek: Mobility, a novel by Lydia Kiesling - ListenMobility by Lydia KieslingMobility by Lydia Kiesling | 9781638930563Sneak Peek: Mobility, a novel by Lydia KieslingMobility - Lydia KieslingMobility, A Novel - Epub( by User 520304661
Figure S15 from Comparative genomic analysis of the ‘psuedofungus’ Hyphochytrium catenoides.
Creators: name: Leonard, Guy
name: Labarre, Aurélie
name: Milner, David S.
name: Monier, Adam
name: Soanes, Darren
name: Wideman, Jeremy G.
name: Maguire, Finlay
name: Stevens, Sam
name: Sain, Divya
name: Grau-Bove, Xavier
name: Arnau Sebe-Pedros
name: Stajich, Jason E.
name: Paszkiewicz, Konrad
name: Brown, Matthew W.
name: Hall, Neil
name: Wickstead, Bill
name: Richards, Thomas A.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 60408 Genomics
subject: FOS: Biological sciences

description: Eukaryotic microbes have three primary mechanisms for obtaining nutrients and energy: phagotrophy, photosynthesis and osmotrophy. Traits associated with the latter two functions arose independently multiple times in the eukaryotes. Fungi successfully coupled osmotrophy with filamentous growth, similar traits are also manifested in the Pseudofungi (oomycetes and hyphochytriomycetes). Both the Fungi and the Pseudofungi encompass a diversity of plant and animal parasites. Genome-sequencing efforts have focused on host-associated microbes (mutualistic symbionts or parasites), providing limited comparisons with free-living relatives. Here we report the first draft genome sequence of a hyphochytriomycete ‘pseudofungus’; Hyphochytrium catenoides. Using phylogenomic approaches, we identify genes of recent viral ancestry, with related viral derived genes also present on the genomes of oomycetes, suggesting a complex history of viral coevolution and integration across the Pseudofungi. H. catenoides has a complex life cycle involving diverse filamentous structures and a flagellated zoospore with a single anterior-tinselate flagellum. We use genome comparisons, drug sensitivity analysis and high-throughput culture arrays to investigate the ancestry of oomycete/pseudofungal characteristics and metabolic traits, demonstrating that many of the genetic features associated with pathogenic traits evolved specifically within the oomycete radiation. Comparative genomics also identified differences in the repertoire of genes associated with filamentous growth between the Fungi and the Pseudofungi, including differences in vesicle trafficking systems, cell-wall synthesis pathways and motor protein repertoire, demonstrating that unique cellular systems underpinned the convergent evolution of filamentous osmotrophic growth in these two eukaryotic groups.
[Kindle] EL HIJO DE LA BESTIA Y OTROS RELATOS DE TERROR Y SEXO EXTRAVAGANT E descargar gratis
Creators: name: Brown
Publisher: name: Zenodo
Year: 2024

description: EL HIJO DE LA BESTIA Y OTROS RELATOS DE TERROR Y SEXO EXTRAVAGANT E de GRAHAM MASTERTON

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EL HIJO DE LA BESTIA Y OTROS RELATOS DE TERROR Y SEXO EXTRAVAGANT E

GRAHAM MASTERTON

Número de páginas: 464

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788477027560

Editorial: VALDEMAR

Año de edición: 2013

 

 

 

 

 

Descargar libro en formato pdf EL HIJO DE LA BESTIA Y OTROS RELATOS DE TERROR Y SEXO EXTRAVAGANT E de GRAHAM MASTERTON

 

Overview

En El Hijo de la Bestia y otras historias de terror y sexo extravagante, Graham Masterton nos lleva a escenarios y situaciones propias del género de terror, donde el sexo ejerce como núcleo o motor del relato tiñéndolo todo con el color de las pesadillas, de modo que po­drían ser calificadas como historias que te calientan la sangre mientras un escalofrío te recorre las vértebras. Son relatos duros, inquietantes, extraños, exagerados y terroríficos, en los que se impone ante todo la maestría de Masterton para mezclar los diversos ingredientes en un cóctel explosivo rebosante de terror y humor negro.
Additional file 6 of Oral health-related quality of life in 4–16-year-olds with and without juvenile idiopathic arthritis
Creators: name: Gil, Elisabeth G.
name: Skeie, Marit S.
name: Halbig, Josefine
name: Jönsson, Birgitta
name: Lie, Stein Atle
name: Rygg, Marite
name: Fischer, Johannes
name: Rosén, Annika
name: Bletsa, Athanasia
name: Luukko, Keijo
name: Shi, Xie-Qi
name: Frid, Paula
name: Cetrelli, Lena
name: Tylleskär, Karin
name: Rosendahl, Karen
name: Åstrøm, Anne N.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 6. Description of JIA-specific background variables.
microRNAs and muscle disorders
Creators: name: Callis, Thomas E.
name: Chen, Jian Fu
name: Wang, Da Zhi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: MicroRNAs (miRNAs) are a class of non-coding regulatory RNAs of ∼22 nucleotides in length. miRNAs are highly conserved across a number of species, including plants, worms and humans. miRNAs regulate gene expression post-transcriptionally, primarily by associating with the 3′ untranslated region (UTR) of their regulatory target mRNAs. Recent work has begun to reveal roles for miRNAs in a wide range of biological processes, including cell proliferation, differentiation and apoptosis. miRNAs are expressed in cardiac and skeletal muscle, and dysregulated miRNA expression has been correlated with muscle-related disorders. Genetic studies have identified distinct roles for specific miRNAs during cardiogenesis, cardiac hypertrophy and electrical conduction. Furthermore, conditionally inhibiting the maturation of miRNAs in mouse cardiac and skeletal muscles has revealed that miRNAs are essential for the development and function of those muscles. These previously unrecognized regulators shed new light on the molecular mechanisms that underlie muscle development and pathology, and suggest the potential importance of miRNAs as diagnostic markers and therapeutic targets for muscle-related disease.
Read online: Done and Dusted: A Rebel Blue Ranch Novel by Lyla Sage
Creators: name: Fell
Publisher: name: Zenodo
Year: 2024

description: Done and Dusted: A Rebel Blue Ranch Novel by Lyla Sage

 

 

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Done and Dusted: A Rebel Blue Ranch Novel

Lyla Sage

Page: 368

Format: pdf, ePub, mobi, fb2

ISBN: 9780593732427

Publisher: Random House Publishing Group

 

Books in french download Done and Dusted: A Rebel Blue Ranch Novel

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The Carina Project. VIII. The α-element abundances
Creators: name: Fabrizio, M.
name: Nonino, M.
name: Bono, G.
name: Primas, F.
name: Thévenin, F.
name: Stetson, P. B.
name: Cassisi, S.
name: Buonanno, R.
name: Coppola, G.
name: da Silva, R. O.
name: Dall'Ora, M.
name: Ferraro, I.
name: Genovali, K.
name: Gilmozzi, R.
name: Iannicola, G.
name: Marconi, M.
name: Monelli, M.
name: Romaniello, M.
name: Walker, A. R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We have performed a new abundance analysis of Carina Red Giant (RG) stars from spectroscopic data collected with UVES (high resolution) and FLAMES/GIRAFFE (high and medium resolution) at ESO/VLT. The former sample includes 44 RGs, while the latter consists of 65 (high) and ~800 (medium resolution) RGs, covering a significant fraction of the galaxy's RG branch (RGB), and red clump stars. To improve the abundance analysis at the faint magnitude limit, the FLAMES/GIRAFFE data were divided into ten surface gravity and effective temperature bins. The spectra of the stars belonging to the same gravity/temperature bin were stacked. This approach allowed us to increase by at least a factor of five the signal-to-noise ratio in the faint limit (V>20.5mag). We took advantage of the new photometry index cU,B,I introduced by Monelli et al. (2014), as an age and probably a metallicity indicator, to split stars along the RGB. These two stellar populations display distinct [Fe/H] and [Mg/H] distributions: their mean Fe abundances are -2.15$\pm$0.06dex (sig=0.28), and -1.75$\pm$0.03dex (sig=0.21), respectively. The two iron distributions differ at the 75% level. This supports preliminary results by Lemasle et al. (2012) and by Monelli et al. (2014). Moreover, we found that the old and intermediate-age stellar populations have mean [Mg/H] abundances of -1.91$\pm$0.05dex (sig=0.22) and -1.35$\pm$0.03dex (sig=0.22); these differ at the 83% level. Carina's α-element abundances agree, within 1sigma, with similar abundances for field Halo stars and for cluster (Galactic, Magellanic) stars. The same outcome applies to nearby dwarf spheroidals and ultra-faint dwarf galaxies, in the iron range covered by Carina stars. Finally, we found evidence of a clear correlation between Na and O abundances, thus suggesting that Carina's chemical enrichment history is quite different than in the globular clusters.
description: 21 pages, 19 figures, 11 tables, accepted for publication in A&A
Investigation on Physical Distancing Measures for COVID-19 Mitigation of Rail Operation in Bangkok, Thailand
Creators: name: Somsiri Siewwuttanagul
Publisher: name: Thammasat Printing House
Year: 2020
Subjects: COVID-19 Pandemic
Metro Operation
Physical Distancing
Public Transportation
Risk of Virus Transmission

description: International Journal of Building, Urban, Interior and Landscape Technology, 15, , 93-102
Structural diversity, biosynthesis, and biological functions of lipopeptides from Streptomyces
Creators: name: Zhang, Songyao
name: Chen, Yunliang
name: Zhu, Jing
name: Lu, Qiujie
name: Cryle, Max
name: Zhang, Youming
name: Yan, Fu
Publisher: name: Monash University
Year: 2023
Subjects: Natural products and bioactive compounds
Proteins and peptides

description: Streptomyces are ubiquitous in terrestrial and marine environment, where they display a fascinating metabolic diversity. As a result, these bacteria are a prolific source of active natural products. One important class of these natural products is the nonribosomal lipopeptides, which have diverse biological activities and play important roles in the lifestyle of Streptomyces. The importance of this class is highlighted by the use of related antibiotics in the clinic, such as daptomycin (tradename Cubicin). By virtue of recent advances spanning chemistry and biology, significant progress has been made in biosynthetic studies on the lipopeptide antibiotics produced by Streptomyces. This review will serve as a comprehensive guide for researchers working in this multidisciplinary field, providing a summary of recent progress regarding the investigation of lipopeptides from Streptomyces. In particular, we highlight the structures, properties, biosynthetic mechanisms, chemical and chemoenzymatic synthesis, and biological functions of lipopeptides. In addition, the application of genome mining techniques to Streptomyces that have led to the discovery of many novel lipopeptides is discussed, further demonstrating the potential of lipopeptides from Streptomyces for future development in modern medicine.
(2811) Edward Irving
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
One level density of low-lying zeros of quadratic Hecke $L$-functions of Imaginary Quadratic Number Fields
Creators: name: Gao, Peng
name: Zhao, Liangyi
Publisher: name: arXiv
Year: 2017
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: In this paper, we prove a one level density result for the low-lying zeros of quadratic Hecke $L$-functions of imaginary quadratic number fields of class number one. As a corollary, we deduce, essentially, that at least $(19-\cot (1/4))/16 = 94.27... \%$ of the $L$-functions under consideration do not vanish at $1/2$.
description: 14 pages. arXiv admin note: text overlap with arXiv:1710.04909
Additional file 7 of Oral health-related quality of life in 4–16-year-olds with and without juvenile idiopathic arthritis
Creators: name: Gil, Elisabeth G.
name: Skeie, Marit S.
name: Halbig, Josefine
name: Jönsson, Birgitta
name: Lie, Stein Atle
name: Rygg, Marite
name: Fischer, Johannes
name: Rosén, Annika
name: Bletsa, Athanasia
name: Luukko, Keijo
name: Shi, Xie-Qi
name: Frid, Paula
name: Cetrelli, Lena
name: Tylleskär, Karin
name: Rosendahl, Karen
name: Åstrøm, Anne N.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Additional file 7. Table S1. Categories for JIA-specific background variables, as originally coded and re-coded for analyses.
Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with  v 3 integrin that activates PKC  and RhoA
Creators: name: Muñoz, Nicolás
name: Quest, Andrew F.G.
name: Chiong, Mario
name: Burridge, Keith
name: Schneider, Pascal
name: Avalos, Ana María
name: Leyton, Lisette
name: Herrera-Molina, Rodrigo
name: Tapia, Julio C.
name: Valdivia, Alejandra D.
name: Lavandero, Sergio
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Clustering of αvβ3 integrin after interaction with the RGD-like integrin-binding sequence present in neuronal Thy-1 triggers formation of focal adhesions and stress fibers in astrocytes via RhoA activation. A putative heparin-binding domain is present in Thy-1, raising the possibility that this membrane protein stimulates astrocyte adhesion via engagement of an integrin and the proteoglycan syndecan-4. Indeed, heparin, heparitinase treatment and mutation of the Thy-1 heparin-binding site each inhibited Thy-1-induced RhoA activation, as well as formation of focal adhesions and stress fibers in DI TNC1 astrocytes. These responses required both syndecan-4 binding and signaling, as evidenced by silencing syndecan-4 expression and by overexpressing a syndecan-4 mutant lacking the intracellular domain, respectively. Furthermore, lack of RhoA activation and astrocyte responses in the presence of a PKC inhibitor or a dominant-negative form of PKCα implicated PKCα and RhoA activation in these events. Therefore, combined interaction of the astrocyte αvβ3-integrin–syndecan-4 receptor pair with Thy-1, promotes adhesion to the underlying matrix via PKCα- and RhoA-dependent pathways. Importantly, signaling events triggered by such receptor cooperation are shown here to be the consequence of cell-cell rather than cell-matrix interactions. These observations are likely to be of widespread biological relevance because Thy-1–integrin binding is reportedly relevant to melanoma invasion, monocyte transmigration through endothelial cells and host defense mechanisms.
[PDF] The Coworker by Freida McFadden
Creators: name: Johnson
Publisher: name: Zenodo
Year: 2024

description: The Coworker by Freida McFadden

 

 

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The Coworker

Freida McFadden

Page: 368

Format: pdf, ePub, mobi, fb2

ISBN: 9781728296203

Publisher: Sourcebooks

 

Free english ebook download The Coworker (English literature)

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The transmembrane protein CBP plays a role in transiently anchoring small clusters of Thy-1, a GPI-anchored protein, to the cytoskeleton
Creators: name: Jacobson, Ken
name: Chen, Yun
name: Benistant, Christine
name: Veracini, Laurence
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: It remains unclear how GPI-anchored proteins (GPIAPs), which lack cytoplasmic domains, transduce signals triggered by specific ligation. Such signal transduction has been speculated to require the ligated GPIAP to associate with membrane-spanning proteins that communicate with obligate cytoplasmic proteins. Transient anchorage of crosslinked proteins on the cell surface was previously characterized by single-particle tracking, and temporary association with the actin cytoskeleton was hypothesized to cause regulated anchorage. GPIAPs, such as Thy-1, require clustering, cholesterol and Src-family kinase (SFK) activity to become transiently anchored. By contrast, a transmembrane protein, the cystic fibrosis transmembrane conductance regulator (CFTR), which has a PDZ-binding motif in its cytoplasmic C-terminus that binds the ERM adaptor EBP50, exhibits anchorage that strictly requires EBP50 but has little dependence on cholesterol or SFK. We hypothesized that a transmembrane protein would be required to mediate the linkage between Thy-1 and the cytoskeleton. Here, we present evidence, obtained by shRNA knockdown, that the transmembrane protein Csk-binding protein (CBP) plays an obligatory role in the transient anchorage of Thy1. Furthermore, either a dominant-negative form of CBP that did not bind EBP50 or a dominant-negative EBP50 drastically reduced transient anchorage of Thy-1, indicating the involvement of this adaptor. Finally, we speculate on the role of phosphorylation in the regulation of transient anchorage.
Charged residues in the C-terminus of the P2Y1 receptor constitute a basolateral-sorting signal
Creators: name: Wolff, Samuel C.
name: Nicholas, Robert A.
name: Qi, Ai Dong
name: Harden, T. Kendall
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The P2Y1 receptor is localized to the basolateral membrane of polarized Madin-Darby canine kidney (MDCK) cells. In the present study, we identified a 25-residue region within the C-terminal tail (C-tail) of the P2Y1 receptor that directs basolateral sorting. Deletion of this sorting signal caused redirection of the receptor to the apical membrane, indicating that the region from the N-terminus to transmembrane domain 7 (TM7) contains an apical-sorting signal that is overridden by a dominant basolateral signal in the C-tail. Location of the signal relative to TM7 is crucial, because increasing its distance from the end of TM7 resulted in loss of basolateral sorting. The basolateral-sorting signal does not use any previously established basolateral-sorting motifs, i.e. tyrosine-containing or di-hydrophobic motifs, for function, and it is functional even when inverted or when its amino acids are scrambled, indicating that the signal is sequence independent. Mutagenesis of different classes of amino acids within the signal identified charged residues (five basic and four acidic amino acids in 25 residues) as crucial determinants for sorting function, with amidated amino acids having a lesser role. Mutational analyses revealed that whereas charge balance (+1 overall) of the signal is unimportant, the total number of charged residues (nine), either positive or negative, is crucial for basolateral targeting. These data define a new class of targeting signal that relies on total charge and might provide a common mechanism for polarized trafficking of epithelial proteins.
Occludin is required for cytokine-induced regulation of tight junction barriers
Creators: name: Holmes, Jennifer
name: Fanning, Alan S.
name: Van Itallie, Christina M.
name: Anderson, James M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The function of occludin remains elusive. Proposed roles include maintenance of tight junction barriers, signaling and junction remodeling. To investigate a potential role in mediating cytokine-induced changes in barrier properties, we measured barrier responses to interferon-γ plus TNFα in control, occludin-overexpressing and occludin knockdown MDCK II monolayers. MDCK cells show a complex response to cytokines characterized by a simultaneous increase in the transepithelial electrical resistance and a decrease in the barrier for large solutes. We observed that overexpression of occludin increased and occludin knockdown decreased sensitivity to cytokines as assessed by both these parameters. It is known that caveolin-1 interacts with occludin and is implicated in several models of cytokine-dependent barrier disruption; we found that occludin knockdown altered the subcellular distribution of caveolin-1 and that partitioning of caveolin into detergent-insoluble lipid rafts was influenced by changing occludin levels. Knockdown of caveolin decreased the cytokine-induced flux increase, whereas the increase in the electrical barrier was unaltered; the effect of double knockdown of occludin and caveolin was similar to that of occludin single knockdown, consistent with the possibility that they function in the same pathway. These results demonstrate that occludin is required for cells to transduce cytokine-mediated signals that either increase the electrical barrier or decrease the large solute barrier, possibly by coordinating the functions of caveolin-1.
Quantum Mechanics in a Time-Asymmetric Universe: On the Nature of the Initial Quantum State
Creators: name: Chen, Eddy Keming
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: High Energy Physics - Theory (hep-th)
subject: History and Philosophy of Physics (physics.hist-ph)
subject: FOS: Physical sciences

description: In a quantum universe with a strong arrow of time, we postulate a low-entropy boundary condition (the Past Hypothesis) to account for the temporal asymmetry. In this paper, I show that the Past Hypothesis also contains enough information to simplify the quantum ontology and define a natural initial condition. First, I introduce Density Matrix Realism, the thesis that the quantum state of the universe is objective and impure. This stands in sharp contrast to Wave Function Realism, the thesis that the quantum state of the universe is objective and pure. Second, I suggest that the Past Hypothesis is sufficient to determine a natural density matrix, which is simple and unique. This is achieved by what I call the Initial Projection Hypothesis: the initial density matrix of the universe is the (normalized) projection onto the Past Hypothesis subspace (in the Hilbert space). Third, because the initial quantum state is unique and simple, we have a strong case for the Nomological Thesis: the initial quantum state of the universe is on a par with laws of nature. This new package of ideas has several interesting implications, including on the harmony between statistical mechanics and quantum mechanics, theoretical unity of the universe and the subsystems, and the alleged conflict between Humean supervenience and quantum entanglement.
description: Minor changes to conform to the published version
Welcome to a new kind of tension: translating kinetochore mechanics into a wait-anaphase signal
Creators: name: Salmon, E. D.
name: Maresca, Thomas J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Recent high-resolution studies of kinetochore structure have transformed the way researchers think about this crucial macro-molecular complex, which is essential for ensuring chromosome segregation occurs faithfully during cell division. Kinetochores mediate the interaction between chromosomes and the plus-ends of dynamic spindle microtubules and control the timing of anaphase onset by regulating the spindle assembly checkpoint (SAC). There is much debate in the SAC research community as to whether mitotic cells sense only microtubule attachment at the kinetochore, or both attachment and tension, before committing to anaphase. In this Commentary, we present a brief history of the tension-versus-attachment debate, summarize recent advances in our understanding of kinetochore structure and focus on the implications of a phenomenon known as intrakinetochore stretch for SAC regulation. We also hypothesize how intrakinetochore stretch might impact SAC function by regulating both microtubule attachment stability and the localization and activity of checkpoint components at the kinetochore.
Read [Pdf]> Monster Crush by Erin Ellie Franey
Creators: name: Isom
Publisher: name: Zenodo
Year: 2024

description: Monster Crush by Erin Ellie Franey

 

 

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Monster Crush

Erin Ellie Franey

Page: 272

Format: pdf, ePub, mobi, fb2

ISBN: 9781506726878

Publisher: Dark Horse Comics

 

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Overview

A whirlwind adventure exploring love, gender, and big emotions, Monster Crush is the perfect read for anyone who’s ever felt like an outsider. Since her parents split up, Ruby Reid has been having a tough time at Crestwood High. But everything changes the day Ella Mooney moves to town. Ella isn’t like most teens: she’s never been on a Ferris wheel, never had an ice cream cone, and sometimes she grows fangs and a tail! It’s not just Ruby who takes an interest in the new girl, and the pair find themselves on the run from a mysterious group that wants to capture Ella and her whole family!
D3.3 API, Library and Security Primitives Implementation - Initial
Creators: name: Razvan Deaconescu
name: Raiciu, Costin
name: Huici, Felipe
name: Kuenzer, Simon
name: Gaulthier Gain
name: Soldani, Cyril
name: Giuffrida, Cristiano
name: Bos, Herbert
Publisher: name: Zenodo
Year: 2020
Subjects: unikernels
unikraft
API
libraries
nginx
Redis
SQLite
applications
VM
virtual machine
IoT
NFV
Serverless Computing
Smart Contracts
toolchain
toolkit

description: In the deliverable we provide the initial implementation of the UNICORE APIs, along with an initial set of libraries. This set supports multiple applications (nginx, Redis, SQLite) available for the project use cases. We recall the overall design of UNICORE APIs together with a list of external libraries and applications. External libraries and applications are linked to required UNICORE APIs to create specialized (small and fast) unikernel images. We also describe the initial implementation of security and safety primitives. The goal of the EU-funded UNICORE project is to develop a common code-base and toolchain that will enable software developers to rapidly create secure, portable, scalable, high-performance solutions starting from existing applications. The key to this is to compile an application into very light-weight virtual machines – known as unikernels – where there is no traditional operating system, only the specific bits of operating system functionality that the application needs. The resulting unikernels can then be deployed
 and run on standard high-volume servers or cloud computing infrastructure.
Figure S14 from Comparative genomic analysis of the ‘psuedofungus’ Hyphochytrium catenoides.
Creators: name: Leonard, Guy
name: Labarre, Aurélie
name: Milner, David S.
name: Monier, Adam
name: Soanes, Darren
name: Wideman, Jeremy G.
name: Maguire, Finlay
name: Stevens, Sam
name: Sain, Divya
name: Grau-Bove, Xavier
name: Arnau Sebe-Pedros
name: Stajich, Jason E.
name: Paszkiewicz, Konrad
name: Brown, Matthew W.
name: Hall, Neil
name: Wickstead, Bill
name: Richards, Thomas A.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 60408 Genomics
subject: FOS: Biological sciences

description: Eukaryotic microbes have three primary mechanisms for obtaining nutrients and energy: phagotrophy, photosynthesis and osmotrophy. Traits associated with the latter two functions arose independently multiple times in the eukaryotes. Fungi successfully coupled osmotrophy with filamentous growth, similar traits are also manifested in the Pseudofungi (oomycetes and hyphochytriomycetes). Both the Fungi and the Pseudofungi encompass a diversity of plant and animal parasites. Genome-sequencing efforts have focused on host-associated microbes (mutualistic symbionts or parasites), providing limited comparisons with free-living relatives. Here we report the first draft genome sequence of a hyphochytriomycete ‘pseudofungus’; Hyphochytrium catenoides. Using phylogenomic approaches, we identify genes of recent viral ancestry, with related viral derived genes also present on the genomes of oomycetes, suggesting a complex history of viral coevolution and integration across the Pseudofungi. H. catenoides has a complex life cycle involving diverse filamentous structures and a flagellated zoospore with a single anterior-tinselate flagellum. We use genome comparisons, drug sensitivity analysis and high-throughput culture arrays to investigate the ancestry of oomycete/pseudofungal characteristics and metabolic traits, demonstrating that many of the genetic features associated with pathogenic traits evolved specifically within the oomycete radiation. Comparative genomics also identified differences in the repertoire of genes associated with filamentous growth between the Fungi and the Pseudofungi, including differences in vesicle trafficking systems, cell-wall synthesis pathways and motor protein repertoire, demonstrating that unique cellular systems underpinned the convergent evolution of filamentous osmotrophic growth in these two eukaryotic groups.
Dynamic localization of C. elegans TPR-GoLoco proteins mediates mitotic spindle orientation by extrinsic signaling
Creators: name: Goldstein, Bob
name: Werts, Adam D.
name: Roh-Johnson, Minna
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Cell divisions are sometimes oriented by extrinsic signals, by mechanisms that are poorly understood. Proteins containing TPR and GoLoco-domains (C. elegans GPR-1/2, Drosophila Pins, vertebrate LGN and AGS3) are candidates for mediating mitotic spindle orientation by extrinsic signals, but the mechanisms by which TPR-GoLoco proteins may localize in response to extrinsic cues are not well defined. The C. elegans TPR-GoLoco protein pair GPR-1/2 is enriched at a site of contact between two cells – the endomesodermal precursor EMS and the germline precursor P2 – and both cells align their divisions toward this shared cell-cell contact. To determine whether GPR-1/2 is enriched at this site within both cells, we generated mosaic embryos with GPR-1/2 bearing a different fluorescent tag in different cells. We were surprised to find that GPR-1/2 distribution is symmetric in EMS, where GPR-1/2 had been proposed to function as an asymmetric cue for spindle orientation. Instead, GPR-1/2 is asymmetrically distributed only in P2. We demonstrate a role for normal GPR-1/2 localization in P2 division orientation. We show that MES-1/Src signaling plays an instructive role in P2 for asymmetric GPR-1/2 localization and normal spindle orientation. We ruled out a model in which signaling localizes GPR-1/2 by locally inhibiting LET-99, a GPR-1/2 antagonist. Instead, asymmetric GPR-1/2 distribution is established by destabilization at one cell contact, diffusion, and trapping at another cell contact. Once the mitotic spindle of P2 is oriented normally, microtubule-dependent removal of GPR-1/2 prevented excess accumulation, in an apparent negative-feedback loop. These results highlight the role of dynamic TPR-GoLoco protein localization as a key mediator of mitotic spindle alignment in response to instructive, external cues.
High Performance X-Ray Transmission Windows Based on Graphenic Carbon
Creators: name: Huebner, Sebastian
name: Miyakawa, Natsuki
name: Kapser, Stefan
name: Pahlke, Andreas
name: Kreupl, Franz
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Instrumentation and Detectors (physics.ins-det)
subject: FOS: Physical sciences

description: A novel x-ray transmission window based on graphenic carbon has been developed with superior performance compared to beryllium transmission windows that are currently used in the field. Graphenic carbon in combination with an integrated silicon frame allows for a window design which does not use a mechanical support grid or additional light blocking layers. Compared to beryllium, the novel x-ray transmission window exhibits an improved transmission in the low energy region ($0.1 hbox{keV}-3 hbox{keV}$ ) while demonstrating excellent mechanical stability, as well as light and vacuum tightness. Therefore, the newly established graphenic carbon window, can replace beryllium in x-ray transmission windows with a nontoxic and abundant material. Index terms: Beryllium, Carbon, Graphene, Thin films, X-ray applications, X-ray detectors
Table S1 from Comparative genomic analysis of the ‘psuedofungus’ Hyphochytrium catenoides
Creators: name: Leonard, Guy
name: Labarre, Aurélie
name: Milner, David S.
name: Monier, Adam
name: Soanes, Darren
name: Wideman, Jeremy G.
name: Maguire, Finlay
name: Stevens, Sam
name: Sain, Divya
name: Grau-Bove, Xavier
name: Arnau Sebe-Pedros
name: Stajich, Jason E.
name: Paszkiewicz, Konrad
name: Brown, Matthew W.
name: Hall, Neil
name: Wickstead, Bill
name: Richards, Thomas A.
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 60408 Genomics
subject: FOS: Biological sciences

description: Meiosis specific gene families and their presence in H. catenoides
Addressing the gas kinetics Boltzmann equation with branching-path statistics
Creators: name: Terrée, Guillaume
name: Hafi, Mouna El
name: Blanco, Stéphane
name: Fournier, Richard
name: Dauchet, Jérémi
name: Gautrais, Jacques
Publisher: name: arXiv
Year: 2017
Subjects: subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences
subject: 76P10

description: This article proposes a new statistical numerical method to address gas kinetics problems obeying the Boltzmann equation. This method is inspired from some Monte-Carlo algorithms used in linear transport physics, where virtual particles are followed backwards in time along their paths. The non-linear character of gas kinetics translates, in the numerical simulations presented here, in branchings of the virtual particle paths. The obtained algorithms have displayed in the few tests presented here two noticeable qualities: (1) They involve no mesh. (2) They allow to easily compute the gas density at rarefied places of the phase space, for example at high kinetic energy.
Book Review:Drawing from the Model: Fundamentals of Digital Drawing, 3D Modeling, and Visual Programming in Architectural Design
Creators: name: Prittipoen Lopkerd
Publisher: name: Thammasat Printing House
Year: 2020
Subjects: Book Review:Drawing from the Model: Fundamentals of Digital Drawing, 3D Modeling, and Visual Programming in Architectural Design

description: International Journal of Building, Urban, Interior and Landscape Technology, 15, , 103-108
[ePub] HEMATOLOGÍA: MANUAL BÁSICO RAZONADO 4ª ED. descargar gratis
Creators: name: Lewis
Publisher: name: Zenodo
Year: 2024

description: HEMATOLOGÍA: MANUAL BÁSICO RAZONADO 4ª ED. de

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HEMATOLOGÍA: MANUAL BÁSICO RAZONADO 4ª ED.

 

Número de páginas: 312

Idioma: CASTELLANO

Formatos: Pdf, ePub, MOBI, FB2

ISBN: 9788490228265

Editorial: S.A. ELSEVIER ESPAÑA

Año de edición: 2015

 

 

 

 

 

Descarga gratuita del foro de libros electrónicos HEMATOLOGÍA: MANUAL BÁSICO RAZONADO 4ª ED.

 

Overview

Esta nueva edición incropora las diversas novedades que han aparecido poniendo especial énfasis en los últimos hallazgos moleculares de las enfermedades de la sangre, las recientes innovaciones terapéuticas, y las actualizaciones en criterios diagnósticos y factores pronósitocos. Proporciona a los estudiantes de ciencias biomédicas un contenido integrado, uniforme y práctico de los conocimientos básicos (clínicos y biológicos) de Hematología que es necesario adquirir durante la formación pregraduada.Desarrolla cada capítulo en forma de preguntas breves seguidas de respuestas razonadas. Los cuadros de llamada al margen y las advertencias del contenido de aparición frecuente en el examen MIR también se han utilizado. Como en ediciones anteriores la relación integrada de distintos conceptos será un rasgo distintivo de esta obra, a través de las numerosas referencias cruzadas entre las preguntas de diferentes capítulos.Proporciona a los estudiantes de ciencias biomédicas españoles e iberoamericanos un contenido integrado, uniforme y práctico de los conocimientos básicos (clínicos y biológicos) de Hematología que es necesario adquirir durante la formación pregraduada. Cabe destacar en este sentido una puesta al día de los mecanismos biológicos de las enfermedades hematológicas, los nuevos criterios diagnósti...