cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Tumor-Suppressive miR-192-5p Has Prognostic Value in Pancreatic Ductal Adenocarcinoma
Creators: name: Flammang, Isabelle
name: Reese, Moritz
name: Yang, Zixuan
name: Eble, Johannes A.
name: Dhayat, Sameer
Publisher: name: University of Muenster, Institutional Repository MIAMI
Year: 2022
Subjects: subject: 610 Medicine and health

description: Pancreatic ductal adenocarcinoma (PDAC) is characterized by fast tumor progression and diagnosis at advanced, inoperable stages. Previous studies could demonstrate an involvement of miR-192-5p in epigenetic regulation of visceral carcinomas. Due to contradictory results, however, the clinical utility of miR-192-5p in PDAC has yet to be determined. MiR-192-5p expression was analyzed by RT-qRT-PCR in human PDAC and benign tissue (n = 78), blood serum (n = 81) and serum exosomes (n = 74), as well as in PDAC cell lines (n = 5), chemoresistant cell clones (n = 2), and pancreatic duct cell line H6c7. Analysis of EMT-associated (epithelial-to-mesenchymal transition) proteins was performed by immunohistochemistry and Western blot. MiR-192-5p was deregulated in PDAC as compared to healthy controls (HCs), with downregulation in macrodissected tissue (p < 0.001) and upregulation in blood serum of PDAC UICC (Union for International Cancer Control) stage IV (p = 0.016) and serum exosomes of PDAC UICC stages II to IV (p < 0.001). MiR-192-5p expression in tumor tissue was significantly lower as compared to corresponding peritumoral tissue (PDAC UICC stage II: p < 0.001; PDAC UICC stage III: p = 0.024), while EMT markers ZEB1 and ZEB2 were more frequently expressed in tumor tissue as compared to peritumoral tissue, HCs, and chronic pancreatitis. Tissue-derived (AUC of 0.86; p < 0.0001) and exosomal (AUC of 0.83; p = 0.0004) miR-192-5p could differentiate between PDAC and HCs with good accuracy. Furthermore, high expression of miR-192-5p in PDAC tissue of curatively resected PDAC patients correlated with prolonged overall and recurrence-free survival in multivariate analysis. In vitro, miR-192-5p was downregulated in gemcitabine-resistant cell clones of AsPC-1 (p = 0.029). Transient transfection of MIA PaCa-2 cells with miR-192-5p mimic resulted in downregulation of ZEB2. MiR-192-5p seems to possess a tumor-suppressive role and high potential as a diagnostic and prognostic marker in PDAC.
description: Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).
title: Enhancing priority setting in medical research: is there a case for cumulative benefit-harm assessments?
Creators: name: Menges, Dominik
name: Yebyo, Henock G.
name: Aschmann, Hélène E.
name: Puhan, Milo A.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Background/research question: When making evidence-based treatment recommendations in clinical practice, there is often considerable uncertainty regarding the expected effects of interventions for certain patient subgroups or individual patients. While calls for more trials frequently emerge in[for full text, please go to the a.m. URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
Water Quality Information Models
Creators: name: Cox, Simon J D
name: Simons, Bruce A
Publisher: name: Zenodo
Year: 2022
Subjects: observations, parameters, variables, water-quality, observable, property, chemistry

description: Presentation to Workshop on Water Quality Monitoring, organised by WMO-UNEP-UNESCO-WHO-OGC Includes overview of OGC O&M, WaterML-WQ, SOSA/SSN, ChEBI, QUDT, NERC Vocabulary Service, I-ADOPT
title: Christophe Colomb et la découverte du Nouveau Monde, par M. le marquis de Belloy, compositions et gravures par Léopold Flameng Texte imprimé
Creators: name: de Belloy, Auguste
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: In-4°, 255 p. et pl.
description: Source: Bibliothèque patrimoniale Villon (Rouen), fonds Leber, g-842
Satellite mega-constellation monitoring campaign using the VGOS radiotelescope at Yebes Observatory during a 24-hour VLBI session from the International VLBI Service for Geodesy and Astrometry (IVS)
Creators: name: Bautista-Durán, Marta
name: López-Pérez, José Antonio
Publisher: name: Zenodo
Year: 2024

description: This presentation shows the procedure, set-up and results of a system to measure the impact of radio-signals from satellites in a 24-h VGOS session through the increase in system noise temperature.
Co-designing with adults with acquired neurological disability in the community: A scoping review protocol
Creators: name: D'Cruz, Kate
name: Antonopoulos, S
name: Rothman, R
name: Douglas, Jacinta
name: Winkler, Dianne
name: Oliver, Stacey
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 52
subject: Psychology
subject: FOS: Psychology
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences

description: Introduction Co-designing healthcare research and health services is becoming increasingly prominent. Co-design invites people with disability to leverage their lived experience knowledge to improve service provision, as well as ensuring meaningful and relevant research. Given the emerging nature of the use of co-design with adults with neurological disability, well-defined guidelines on best practice are yet to be developed. The aim of this scoping review is to synthesise available peer-reviewed literature which investigates the use of co-design in research and/or service development with adults who have an acquired neurological disability and live within the community. The findings of this review will help to guide future co-design practice, ensuring people with acquired neurological disability are best supported and engaged in the process. Methods and analysis This review will follow methodology proposed by Arksey and O'Malley and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis: Extension for Scoping Reviews. Systematic electronic database searches will be conducted between the years 2000 and 2022, via MEDLINE, CINAHL, PsycINFO, Scopus and Embase. Article screening and selection will follow the five-stage framework of Arksey and O'Malley, using Covidence software to support review of each retrieved article by two independent reviewers. Final selected qualitative and/or mixed-methods studies that meet the inclusion criteria will be charted, data collated, summarised and reported. Thematic synthesis will be applied to the qualitative data extracted from these studies. Ethics and dissemination Ethics approval will not be required to conduct this scoping review. It is the authors' intention for the findings of this scoping review to be made available to relevant stakeholders through open-access peer-reviewed publication and disseminated with other healthcare and research networks via translation pieces, including the development of short video summaries and practice resources.
title: ADCO, Grènetier de Cîteaux : comptes (1497-1504) (11 H 1172), f. 00504
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: comptes
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172), f. 00504, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
The relationship between fathers' heavy episodic drinking and fathering involvement in five Asia-Pacific countries: An individual participant data meta-analysis
Creators: name: Laslett, Anne-Marie
name: Kuntsche, Sandra
name: Wilson, Ingrid
name: Taft, Angela
name: Fulu, E
name: Jewkes, R
name: Graham, K
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 3202
subject: Clinical sciences
classificationCode: 5202
subject: Biological psychology
classificationCode: 5203
subject: Clinical and health psychology

description: Background: This study aims to increase understanding of the relationship between heavy episodic drinking (HED) and fathers' involvement in parenting in five countries. The potential moderating effect of fathers' experiences of childhood trauma is also studied, controlling for the possible confounding of the effect of HED by father's attitudes toward gender equality, father's age and father's education. Method: United Nations Multi-Country Study on Men and Violence (UNMCS) survey data from 4562 fathers aged 18–49 years from Cambodia, China, Indonesia and Papua New Guinea (PNG) and Sri Lanka were used to assess the relationship between fathering involvement (e.g., helping children with their homework) and self-reported HED of 6+ drinks in one occasion vs. non-HED and abstaining. Moderating effects of a 13-item fathers' childhood trauma (FCT) scale were tested and analyses were adjusted for gender-inequitable attitudes using the Gender-Equitable Men scale score. Bivariate and adjusted individual participant meta-analyses were used to determine effect estimates for each site and across all sites. Results: Fathers' HED was associated with less positive parental involvement after adjusting for gender-equitable attitudes, FCT, age and education. No overall interaction between HED and FCT was identified. Gender equitable attitudes were associated with fathering involvement in some countries but not overall (p = 0.07). Conclusions: Heavy episodic drinking was associated with reduced positive fathering involvement. These findings suggest that interventions to increase fathers' involvement in parenting should include targeting reductions in fathers' HED. Structural barriers to fathers' involvement should be considered alongside HED in future studies of fathers' engagement with their children.
title: Paratexte_Dictionnaire des peintres miniaturistes sur vélin, parchemin, ivoire et écaille
Creators: name: AmateurS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021

description: Paratexte
description: ID_PARA_01103
title: Studie TRADE (TRAnsport und DElir von älteren Menschen) – Entwicklung einer komplexen Intervention zur Delirprävention und -reduktion bei Ortswechsel von älteren Menschen im Akutkrankenhaus
Creators: name: Denninger, Natascha-Elisabeth
name: Dallmeier, Dhayana
name: Carmine, Marlis
name: Bahrmann, Anke
name: Benzinger, Petra
name: Braisch, Ulrike
name: Eggert, Simon
name: Geisler, Tobias
name: Klaus, Jochen
name: Neumann, Anja
name: Denkinger, Michael
name: Müller, Martin
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund/Fragestellung: Ein deutlicher Anstieg der Prävalenz und Inzidenz von Delir bei älteren Menschen im Akutkrankenhaus ist zu verzeichnen. Delir ist assoziiert mit Komplikationen, längerem Krankenhausaufenthalt und erhöhtem Pflegebedarf. Ortswechsel, wie Entlassung oder[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
Themeda triandra as a perennial seed crop in south-eastern Australia: What are the agronomic possibilities and constraints, and future research needs?
Creators: name: Male, Dylan
name: Hunt, James
name: Celestina, Corinne
name: Morgan, John
name: Gupta, Dorin
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 3002
subject: Agriculture, land and farm management
classificationCode: 3003
subject: Animal production
classificationCode: 3006
subject: Food sciences

description: The development of native perennial seed crops is an area of increasing interest in Australia. Key reasons for this include potential production of high-value seed for land restoration and emerging niche food markets, the cultural significance that native plants hold for Aboriginal people, reduced farm input costs in comparison to annual seed crop production and potential environmental benefits from diversified agricultural systems. One species of interest is Themeda triandra, a C4 perennial tussock grass that dominated many grasslands and grassy woodlands across Australia prior to European invasion. This review aims to inform those seeking to grow T. triandra as a seed crop in south-eastern Australia of the genetic, environmental and management factors that influence plant growth, development, and seed yield. By doing so, the review highlights the agronomic possibilities and constraints relating to production of a T. triandra as a seed crop and identifies future research needs. Key agronomic possibilities include the requirement to establish a crop once that can then persist for years; its adaptation to a range of environments and its ability to produce high-value seed every year. Key agronomic constraints include low and variable seed yields, limited knowledge of important aspects of crop management and difficulties in broadacre crop establishment associated with its seed diaspore morphology, low seed quality, germination requirements and weed competition. Future research should investigate ways to maximise seed production through effective crop management, improve upon current sowing and harvest techniques and identify ecotypes with agronomic traits preferable for seed crop production.
title: Metal sources in the actively forming seafloor massive sulfide deposit of the Kolumbo volcano: Insight from the basement rocks
Creators: name:  Hector ,  S.
name:  Patten,  C. G. C.
name:  Kilias ,  S. P.
name:  Papanikolaou ,  D.
name:  Kolb ,  C. G. C.
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: The shallow submarine Kolumbo volcano , located in the 5 Ma-to-present Aegean volcanic arc in Greece, hosts an active hydrothermal system currently forming polymetallic seafloor massive sulfide (SMS) mineralization on the seafloor, with high As, Ag, Au, Hg, Sb and Tl contents. It is one of the few known SMS deposits associated with continental margin volcanism. The hydrothermal system of the Kolumbo volcano represents an active hybrid analogue style of epithermal and VMS mineralization. The particular geological setting of the Kolumbo volcano in the Anydros basin makes it a great natural laboratory to investigate the metal flux as the underlying units outcrop on the neighboring islands of Santorini, Ios and Anafi . To this day, it is not clear to which extend the metals in the fluid derive from a magmatic source or if they are leached from the basement rocks by magmatic-hydrothermal fluids. Whole rock geochemistry of the basement and sedimentary rocks allows identifying the potential metal reservoirs in the system. The basement rocks can add metals to the system either by leaching through magmatic-hydrothermal fluids or contamination of the melt by assimilation. Sulfur and Pb isotope analysis allow to track contribution of the basement rocks to the metals/ligands budget of the fluids by comparison with the sulfates and sulfides of the Kolombo SMS. Constraining the metal reservoirs involved in marine magmatic-hydrothermal systems is crucial to understand the formation of SMS and variability in the metal endowment between the deposits.
Mental and physical health and well-being of Canadian employees who were working from home during the COVID-19 pandemic
Creators: name: Somasundram, KG
name: Hackney, A
name: Yung, M
name: Du, B
name: Oakman, Jodi
name: Nowrouzi-Kia, B
name: Yazdani, A
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 4206
subject: Public health
classificationCode: 4203
subject: Health services and systems
classificationCode: 4202
subject: Epidemiology

description: Background: The COVID-19 pandemic has drastically changed various aspects of our lives, including how we work. Since the start of the pandemic, numerous organizations in Canada have mandated their employees to work from home (WFH) on a full-time basis. The rapid rise in the number of remote workers and the possibility for WFH continuing in the future signifies the importance of understanding the health and well-being of employees working from home over the course of the pandemic in Canada. We present the findings of two surveys (initial and 6-month follow-up) to examine the health and well-being of WFH employees during the COVID-19 pandemic in Canada. We analyzed the changes in mental and physical health and well-being of employees who were working from home between two time points during the pandemic. Methods: Initial survey was completed between October 2020 and December 2020 (n = 1617); follow-up survey was completed between May 2021 and June 2021 (n = 382). We calculated the frequencies for survey questions involving demographics, WFH preferences, workstation setup training, employment situation, provision of hardware technologies, provision and usage of software technologies, and organization’s return to work plan. We conducted Wilcoxon signed-rank tests to analyze the within-individual changes in mental and physical health and well-being of the 382 respondents who completed both the initial and follow-up surveys. Results: Our analyses showed significant changes in various aspects of employee mental and physical health and well-being. Burnout, stress, general mental health, and job insecurity levels significantly decreased between the two time periods. Work-related sedentary behaviour reduced over time; however, the average proportion of time spent sitting during work hours was more than 80% in both surveys. Employees received more help and feedback from their colleagues and experienced a better sense of community with their co-workers over time. Conclusion: The findings can inform workers and organizations on the changes in mental and physical health and well-being of employees working from home during the pandemic. By understanding the changes in worker health and well-being, employers can develop effective strategies and implement policies that help protect employees’ health and well-being.
title: Effekte von Lebensstilinterventionen bei älteren Menschen mit Adipositas (Effective SLOPE) – ein Mixed-Method-Ansatz
Creators: name: Torbahn, Gabriel
name: Schoene, Daniel
name: Schwingshackl, Lukas
name: Rücker, Gerta
name: Görlitz, Anja
name: Koching, Mirjam
name: Volland-Schüssel, Käte
name: Kemmler, Wolfgang
name: Sieber, Cornel
name: Batsis, John
name: Villareal, Dennis
name: Stroebele-Benschop, Nanette
name: Volkert, Dorothee
name: Kiesswetter, Eva
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund/Fragestellung: Adipositas tritt bei ca 35% der Personen über 65 Jahren auf und kann - v. a. in Kombination mit Sarkopenie - schwerwiegende gesundheitliche Auswirkungen haben. Für die Therapie stehen Lebensstilinterventionen (LSI) in den Bereichen: Ernährung, Bewegung,[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
Assessing the environment for engagement in health services: The Audit for Consumer Engagement (ACE) tool
Creators: name: Chauhan, A
name: Newman, B
name: Walpola, RL
name: Seale, H
name: Manias, E
name: Wilson, Carlene
name: Harrison, R
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 4203
subject: Health services and systems
classificationCode: 4206
subject: Public health

description: Introduction: Although it is widely accepted that the physical environment can impact health quality and care outcomes, its impact on consumer engagement with health services has not been examined. Currently, no tools exist that assess the opportunities for consumer engagement offered within the physical environment. We aimed to develop and validate an environmental audit tool to assist health services and researchers to assess the extent to which the physical environment in health services creates and supports opportunities for consumer engagement. Method: An iterative, team-based approach in partnership with diverse stakeholders was used to develop the Audit for Consumer Engagement (ACE) tool. A four-stage process consisting of desktop review, concept clarification, identification of domains and validation was implemented. The tool was validated in one cancer service via face and content validation and inter-rater reliability was also assessed. Results: The ACE tool was demonstrated to comprise four main domains (access and signage information; resources for consumers; resources to support diversity; and consumer engagement events or activities) measured with 17 items. Face and content validity was achieved, and preliminary reliability analysis indicated substantial agreement between the two researchers for all four domains with an average of 86% agreement. Conclusion: The ACE is a novel tool that is practical, relevant and reliable, and developed in partnership with consumers and health service providers. The tool can be used by health service providers, researchers and consumer agency groups to assess opportunities for consumer engagement offered within the physical environment of cancer services. The ACE tool has the potential to be used as a guide for enhancing consumer engagement opportunities and for research purposes. Further evidence about the validity of the tool is required, including criterion-related validity and utility in other health settings.
title: Entwicklung und Pilotierung einer multimodalen Supportivintervention zur Förderung der körperlichen Funktionsfähigkeit älterer Krebspatientinnen und Krebspatienten
Creators: name: Shehu, Eni
name: Roggendorf, Sigrid
name: Golla, André
name: Hübner, Gundula
name: Stangl, Gabriele
name: Lau, Andreas
name: Diestelhorst, Andrea
name: Vordermark, Dirk
name: Steckelberg, Anke
name: Schmidt, Heike
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund/Fragestellung: Ältere Menschen mit Tumorerkrankungen unterscheiden sich besonders bezüglich körperlicher und kognitiver Funktionalität sowie Anzahl und Schwere von Komorbiditäten. Um Risikofaktoren zu identifizieren und in gemeinsame Therapieentscheidungen einzubeziehen,[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
title: ADCO, Ordre cistercien : comptes (1403-1423) (11 H 1161), f. 00009
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Laboratoire de Médiévistique Occidentale de Paris
subject: comptes
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP

description: Ordre cistercien : comptes (1403-1423), Archives départementales de la Côte-d'Or, (11 H 1161). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Ordre cistercien : comptes (1403-1423), Archives départementales de la Côte-d'Or, (11 H 1161), f. 00009, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
title: ‚E-Inclusion’ – eine Benenn-App für Menschen mit Aphasie
Creators: name: Widmer Beierlein, Sandra
name: Kuntner, Katrin
name: Reymond, Claire
name: Blechschmidt, Anja
name: Degen, Markus
name: Shah, Ashesh
name: Müller, Christine
name: Falcón García, Noelia
name: Karlin, Stefan
name: Parrillo, Fabrizio
name: Bucheli, Sandra
name: Elsener, Claudia
name: Reutimann, Riccarda
name: Park, Sunghea
name: Loew, Joelle
name: Hemm, Simone
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund/Fragestellung: E-Inclusion ist ein interdisziplinäres Forschungsprojekt zum Einsatz digitaler Technologien für Menschen mit einer Sprachbehinderung. Ziel ist es, forschungsbasiert eine App für Menschen mit Aphasie zu entwickeln. Forschende aus den Bereichen ‘Life[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VI, Cart. 190 (11 H 75), 316 folios, f. 0112r
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VI, Archives départementales de la Côte-d'Or, Cart. 190 (11 H 75), 316 folios, f. 0112r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome VI, Archives départementales de la Côte-d'Or, Cart. 190 (11 H 75), 316 folios, f. 0112r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
title: Trainingsworkshop: Patient*innenbeteiligung an klinischer Forschung
Creators: name: Schilling, Imke
name: Herbon, Carolin
name: Jilani, Hannah
name: Rathjen, Kim
name: Gerhardus, Ansgar
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Beschreibung: Die Beteiligung von Patient*innen an der Planung, Durchführung und Dissemination von klinischer Forschung gewinnt nun auch im deutschsprachigen Raum zunehmend an Relevanz und wird von Forschungsförderern gefordert. In einem Trainingsworkshop möchten wir Forschenden [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
title: Netzwerk Metaanalysen – von der Methodik zur nützlichen patientenrelevanten Ergebnispräsentation
Creators: name: Piechotta, Vanessa
name: Adams, Anne
name: Ernst, Moritz
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Beschreibung: Netzwerk-Metaanalysen (NMA) sind heutzutage ein relevanter Bestandteil der evidenzbasierten Medizin. Als Erweiterung zur paarweisen Metaanalyse ermöglichen sie den simultanen Vergleich von mehr als zwei Behandlungsoptionen. Für viele Aspekte der Durchführung und Ergebnisdarstellung[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
Neuroinflammatory Modulation of Extracellular Vesicle Biogenesis and Cargo Loading
Creators: name: Spiers, Jereme
name: Vassileff, Natasha
name: Hill, Andrew
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 3209
subject: Neurosciences
subject: FOS: Clinical medicine
classificationCode: 3101
subject: Biochemistry and cell biology

description: Increasing evidence suggests neuroinflammation is a highly coordinated response involving multiple cell types and utilising several different forms of cellular communication. In addition to the well documented cytokine and chemokine messengers, extracellular vesicles (EVs) have emerged as key regulators of the inflammatory response. EVs act as vectors of intercellular communication, capable of travelling between different cells and tissues to deliver selectively packaged protein, miRNA, and lipids from the parent cell. During neuroinflammation, EVs transmit specific inflammatory mediators, particularly from microglia, to promote inflammatory resolution. This mini-review will highlight the novel neuroinflammatory mechanisms contributing to the biogenesis and selective packaging of EVs.
title: Bewertung der methodischen Qualität systematischer Übersichtsarbeiten mit AMSTAR 2
Creators: name: Pieper, Dawid
name: Matthias, Katja
name: Jacobs, Anja
name: Wegewitz, Uta
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Beschreibung: Die Bewertung der methodischen Qualität systematischer Übersichtsarbeiten muss vielfach durchgeführt werden, wie z.B. in Leitlinien oder Overviews. AMSTAR (A Measurement Tool to Assess Systematic Reviews) war bis vor einigen Jahren das am häufigsten verwendete Instrument[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
title: Von Evidenz zu Leitlinienempfehlungen für komplexe Interventionen – Ein Praxisworkshop zum WHO-INTEGRATE Framework
Creators: name: Stratil, Jan Marcel
name: Rehfuess, Eva
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Beschreibung: Die Entwicklung von Leitlinienempfehlungen zu komplexen Interventionen im Bereich Public Health (z.B. einer Zuckersteuer oder Dieselfahrverbote) stellt eine besondere Herausforderung dar. Dies betrifft nicht nur die Untersuchung kausaler Zusammenhänge, sondern auch die zahlreichen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
Objective
Creators: name: Botero, Javier Enrique
Publisher: name: OSF Registries
Year: 2023

description: Given the great importance of oral health and pregnancy complications and to inform clinical practice and public health policy, this systematic review is necessary to update the current knowledge. Additionally, this systematic review can also help in the identification of potential risk factors, prevention methods, and treatment options for pregnant women suffering from periodontitis. Consequently, the objective of this systematic review was to determine the association between periodontitis and low birth weight (LBW) and preterm birth (PTB).
title: Sample Size Estimation, beyond bare numbers
Creators: name: Fabbro, Thomas
name: Dutilh, Gilles
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Description: The estimation of sample size is a crucial step in planning a clinical study and has many implications. Therefore, the evaluation of the consequences of using different analysis methods and different assumptions is crucial. Nevertheless, especially at this early stage of planning, constrains[for full text, please go to the a.m. URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
title: RoB 2 – Das aktualisierte Risk of Bias Tool für RCTs von Cochrane
Creators: name: Bollig, Claudia
name: Nitschke, Kai
name: Möhler, Ralph
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Beschreibung: Das Cochrane Risk of Bias Tool ist ein etabliertes Instrument zur Einschätzung des Bias-Risikos in randomisierten kontrollierten Studien. Das im Jahr 2019 veröffentlichte aktualisierte Cochrane Handbuch für systematische Übersichtsarbeiten zu Interventionen enthält[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
title: Identification of Hindbrain Neural Substrates for Motor Initiation in the hatchling Xenopus laevis Tadpole
Creators: name: Messa, Giulia
Publisher: name: University of Kent
Year: 2022

description: Animal survival profoundly depends on the ability to detect stimuli in the environment, process them and respond accordingly. In this respect, motor responses to a sensory stimulation evolved into a variety of coordinated movements, which involve the control of brain centres over spinal locomotor circuits. The hatchling Xenopus tadpole, even in its embryonic stage, is able to detect external sensory information and to swim away if the stimulus is considered noxious. To do so, the tadpole relies on well-known ascending sensory pathway, which carries the sensory information to the brain. When the stimulus is strong enough, descending interneurons are activated, leading to the excitation of spinal CPG neurons, which causes the undulatory movement of swimming. However, the activation of descending interneurons that marks the initiation of motor response appears after a long delay from the sensory stimulation. Furthermore, the long-latency response is variable in time, as observed in the slow-summating excitation measured in descending interneurons. These two features, i.e. long-latency and variability, cannot be explained by the firing time and pattern of the ascending sensory pathway of the Xenopus tadpole. Therefore, a novel neuronal population has been proposed to lie in the hindbrain of the tadpole, and being able to 'hold' the sensory information, thus accounting for the long and variable delay of swim initiation. In this work, the role of the hindbrain in the maintenance of the long and variable response to trunk skin stimulation is investigated in the Xenopustadpole at developmental stage 37/38. A multifaceted approach has been used to unravel the neuronal mechanisms underlying the delayed motor response, including behavioural experiments, electrophysiology analysis of fictive swimming, hindbrain extracellular recordings and imaging experiments. Two novel neuronal populations have been identified in the tadpole's hindbrain, which exhibit activation patterns compatible with the role of delaying the excitation of the spinal locomotor circuit. Future work on cellular properties and synaptic connections of these newly discovered populations might shed light on the mechanism of descending control active at embryonic stage. Identifying supraspinal neuronal populations in an embryonic organism could aid in understanding mechanisms of descending motor control in more complex vertebrates.
title: Interprofessioneller Studierendentag des EbM-Netzwerks
Creators: name: Panteli, Dimitra
name: Hirt, Julian
name: Nordhausen, Thomas
name: Vetsch, Janine
name: Suter, Katja
name: Briel, Matthias
name: Klager, Elisabeth
name: Cichocki, Martin
name: Gomez Pellin, Maricruz
name: Moussa, Mahmoud
name: Jirovsky, Elena
name: Mansbart, Felix
name: Hemkens, Lars
name: Sönnichsen, Andreas
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Beschreibung: Über evidenzbasierte Medizin bzw. evidenzbasierte Gesundheitsversorgung wird häufig gesprochen, doch die Umsetzung lässt vielerorts zu wünschen übrig. Die Gesundheitsversorgung ist auch fast dreißig Jahre nach den von David Sackett angestoßenen bahnbrechenden[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
title: Wie ethisch ist das Soziale – wie sozial das Ethische? Die Abgrenzungsproblematik der Domänen „Ethik“ und „Soziales“ im Health Technology Assessment
Creators: name: Mertz, Marcel
name: Kahrass, Hannes
name: Dinger, Anna
name: Siering, Ulrich
name: Krabbe, Laura
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Beschreibung: Im Health Technology Assessment (HTA) ist es unterdessen üblich, neben der Nutzenbewertung und der gesundheitsökomischen Betrachtung auch organisatorische, rechtliche, ethische und soziale Aspekte zu bearbeiten. Gerade die Ethik- und Soziales-Domäne können dazu dienen,[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
title: Ausbildung zur Patient*innenvertretung – Wieviel EbM braucht kritische Gesundheitskompetenz?
Creators: name: Mühlhauser, Ingrid
name: Steckelberg, Anke
name: Ehrmann, Udo
name: Berger, Betinna
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Beschreibung:Symposium der Fachbereiche "Patienteninformation & -beteiligung" und "EbM in Aus-, Weiter- und Fortbildung" Moderatorinnen: Ingrid Mühlhauser, Anke Steckelberg Bisher gibt es keine strukturell verankerte Ausbildung zur Patient*innenvertretung.[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
title: Vergleichende Wirksamkeitsforschung partizipativ gestalten: Internationale Modelle und nationale Forschungspraxis
Creators: name: Farin-Glattacker, Erik
name: Voigt-Radloff, Sebastian
name: Kienle, Gunver
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Beschreibung: Weltweit fordern öffentliche Forschungsförderer verstärkt eine partizipative Ausrichtung der patientenrelevanten Wirksamkeitsforschung (vgl. für Deutschland das Rahmenprogramm Gesundheitsforschung der Bundesregierung und für Großbritannien [[link:https://www.invo.org.uk*https://www.invo.org.uk]],[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
title: Entwicklung und Einsatz von Messinstrumenten zur Erfassung der Gesundheitskompetenz bei Kindern und Jugendlichen
Creators: name: Gasteiger-Klicpera, Barbara
name: Steckelberg, Anke
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Beschreibung: Kritische Gesundheitskompetenz ist eine wichtige Voraussetzung, um gesundheitsrelevante Informationen zu verstehen und diese in die eigenen Entscheidungen einzubeziehen. Unter Gesundheitskompetenz versteht man die Fähigkeit, gesundheitsbezogene Informationen zu finden, zu verstehen,[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
title: Informationsbeschaffung für Leitlinien – Standards und praktische Lösungen
Creators: name: Sow, Dorothea
name: Blümle, Anette
name: Nothacker, Monika
name: Schaefer, Corinna
name: Schmidt, Stefanie
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Beschreibung: Im April 2019 wurde das „Manual Systematische Recherche für Evidenzsynthesen und Leitlinien“ in seiner 2. Auflage veröffentlicht. Das Manual bietet Leitlinienautoren eine Orientierung für die Durchführung der systematischen Recherche. Zum einen werden [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
Protect the Player, Protect the Game: Reflections from Ex-Professional Rugby Union Players on Law Changes, Protective Equipment, and Duty of Care in the Professional Game
Creators: name: Daly, E
name: Blackett, AD
name: Pearce, Alan
name: Ryan, L
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 3209
subject: Neurosciences
subject: FOS: Clinical medicine
classificationCode: 4201
subject: Allied health and rehabilitation science
classificationCode: 4207
subject: Sports science and exercise

description: The emphasis of this study was to interview ex-professional male rugby union players (n = 23, mean age 35.5 ± 4.7 years) and discuss concussion management during their careers. In this study, two major themes were identified: (1) the duty of care to professional rugby union players by medical personnel, coaching staff, and owners of professional clubs and (2) the use of protective equipment and law changes to enhance player safety. In total, twenty-three ex-professional rugby union players were interviewed, and the majority (61%) had represented their countries at international test-level rugby. These interviews highlighted the belief that medical teams should be objective, independent entities within a professional rugby club. Furthermore, medical teams should not be in a position of being pressurised by head coaches, members of the coaching team, or club owners regarding return-to-play (RTP) protocols specific to concussion. The interviewees believed that they were pressured by coaches or members of the coaching team to play with concussion or concussive symptoms and other physical injuries. The results indicated that they had manipulated concussion testing themselves or with assistance to pass standard concussion testing protocols. The interviewees indicated that club owners have a duty of care to players even in retirement due to the high incidence of physical and mental injuries endured as a professional rugby player. Most participants indicated that a reduction in match playing time and reducing the amount of time engaged in contact training (workload volume) may assist in reducing concussion incidence. The participants suggested that changes to the current laws of the game or the use of protective equipment did not mitigate against concussion risk in the game of rugby union. The main limitation to the study is that participants had retired in the past ten years, and conditions for players may have changed. This study has highlighted that additional efforts are required by professional clubs to ensure the highest duty of care is delivered to current players and recently retired players.
title: Build a roadmap to excellence in clinical trial reporting for your university
Creators: name: Bruckner, Till
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Description: Many universities are already ensuring that all their clinical trials report results in a timely fashion. How can my own university too achieve excellence and prevent research waste? Intended methods: This workshop will enable participants to create a draft roadmap to excellence[for full text, please go to the a.m. URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
title: Wie bekommen wir freien und digitalen Zugang zu wissenschaftlicher Literatur?
Creators: name: Waffenschmidt, Siw
name: Euler, Ulrike
name: Felgenträger, Katja
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Beschreibung: Zwar ermöglicht die Digitalisierung prinzipell einen unmittelbaren (schnelleren und besseren ) Informationszugang. Trotzdem haben die wenigsten medizinischen Berufsgruppen, Patientinnen, Patienten, Bügerinnen und Bürger ausreichend Zugang zu wissenschaftlich verlässlichen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
title: Cochrane zum Mitmachen
Creators: name: Labonté, Valérie
name: Borchard, Annegret
name: Blümle, Anette
name: Kohler, Katharina
name: von Elm, Erik
name: Meerpohl, Jörg J.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Beschreibung: Die Ergebnisse aus systematischen Reviews sind eine wichtige Grundlage für evidenzbasierte Entscheidungen in der Gesundheitsversorgung und -politik und stoßen zunehmend auch auf das Interesse der breiten Öffentlichkeit. Cochrane bietet allen Interessierten, auch solchen [zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
title: How credible is a subgroup claim? Hands-on workshop using the new ICEMAN tool
Creators: name: Schandelmaier, Stefan
name: Gloy, Viktoria
name: Schmitt, Andreas
name: Briel, Matthias
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Description: Most randomized controlled trials and meta-analyses include analyses of effect modification (mostly in the form of subgroup analyses) to assess whether the effect of an intervention varies by another variable (e.g. age or disease severity). Assessing the credibility of an apparent effect[for full text, please go to the a.m. URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
title: Workshop für Journalisten: Der Medien-Doktor
Creators: name: Koch, Klaus
name: Wormer, Holger
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Beschreibung: Der Medien-Doktor ([link:http://www.medien-doktor.de/gesundheit/*http://www.medien-doktor.de/gesundheit/]) ist ein Angebot von Journalisten für Journalisten, angesiedelt am Lehrstuhl Wissenschaftsjournalismus der Technischen Universität[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin
Antimicrobial Resistance: A Growing Threat
Creators: name: Dr. Vicky Patel1 and Dr. Pragnesh Patel2
Publisher: name: The Science world a Monthly e magazine
Year: 2024

description:  Antimicrobial resistance is an important concern for the public health authorities at global level. In recent decades, the overuse and misuse of antimicrobials in animal health have contributed significantly to the rise of resistant bacteria, posing a serious threat to both animal welfare and public health. Additionally, inadequate infection prevention and control measures in animal production facilities contribute to the spread of resistant bacteria among animals. In this article, we delve into the intricate dynamics of antimicrobial resistance in animal health, examining the underlying causes, exploring its impacts on animal welfare and human health, and discussing potential interventions and strategies to mitigate its effects. By raising awareness and fostering collective action, we can strive towards a future where antimicrobials remain effective tools in safeguarding animal health, human health, and environmental sustainability.