cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
L’istituzione della methodus come processo di fondazione di un sistema dialettico argomentativo nel Quod sit unica doctrinae instituendae methodus ex Aristotelis sententia di Pierre de la Ramée Testo e studio
Creators: name: Salsano, Michela
Publisher: name: Universita degli studi di Salerno
Year: 2020
Subjects: subject: M-FIL/06 STORIA DELLA FILOSOFIA
subject: Metodo
subject: Logica
subject: Dialettica

description: 2018 - 2019
description: The focal aim of this thesis shows the fondative process of the method, within the dialectic-argumentative system by Peter Ramus. The contextual lines of this research are divided in two parts: the first one aimed at the study of some aspects that, Ramus's Quod sit unica doctrinae instituendae methodus, allow to be linked to the speculative context, thus completing the institution of the method. The second part is dedicated to the interpretative edition of the text with a detailed introductory note. .. [edited by Author]
description: La tesi di dottorato della Dott.ssa Salsano, dal titolo L’istituzione della methodus come processo di fondazione di un sistema dialettico argomentativo nel Quod sit unica doctrinae instituendae methodus ex Aristotelis sententia di Pierre de la Ramée (Testo e studio), è stata condotta sotto la guida del tutor italiano, Prof. Francesco Piro e del tutor francese, Prof. Joël Biard. La struttura della ricerca prevede due parti, di cui la prima si svolge lungo l’analisi e lo studio dell’edizione separata del Quod sit unica doctrinae instituendae methodus ex aristotelis sententiae, la cus e IX Animadversionum P.Rami (d’ora in avanti Quod sit), che fece la sua comparsa a Parigi nell’anno salutis 1557. La cinquecentina, stampata presso la bottega di André Wechel, contiene il testo del capitolo IX estratto dalle Aristotelicae animadversiones del 1556 del medesimo autore. Quanto alla seconda parte del lavoro, prevede l’edizione interpretativa del testo dell’Opuscolo, con una cospicua nota introduttiva relativa alle notizie di carattere ecdotico, paleografico, tecnico, storico e redazionale in merito all’opuscolo oggetto della trattazione. .. [a cura dell'Autore]
Deep Learning Criminal Networks
Creators: name: Ribeiro, Haroldo V.
name: Lopes, Diego D.
name: Pessa, Arthur A. B.
name: Martins, Alvaro F.
name: da Cunha, Bruno R.
name: Goncalves, Sebastian
name: Lenzi, Ervin K.
name: Hanley, Quentin S.
name: Perc, Matjaz
Publisher: name: arXiv
Year: 2023
Subjects: subject: Physics and Society (physics.soc-ph)
subject: Social and Information Networks (cs.SI)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Recent advances in deep learning methods have enabled researchers to develop and apply algorithms for the analysis and modeling of complex networks. These advances have sparked a surge of interest at the interface between network science and machine learning. Despite this, the use of machine learning methods to investigate criminal networks remains surprisingly scarce. Here, we explore the potential of graph convolutional networks to learn patterns among networked criminals and to predict various properties of criminal networks. Using empirical data from political corruption, criminal police intelligence, and criminal financial networks, we develop a series of deep learning models based on the GraphSAGE framework that are able to recover missing criminal partnerships, distinguish among types of associations, predict the amount of money exchanged among criminal agents, and even anticipate partnerships and recidivism of criminals during the growth dynamics of corruption networks, all with impressive accuracy. Our deep learning models significantly outperform previous shallow learning approaches and produce high-quality embeddings for node and edge properties. Moreover, these models inherit all the advantages of the GraphSAGE framework, including the generalization to unseen nodes and scaling up to large graph structures.
description: 14 two-column pages, 5 figures
Quantum size effects in layered VX2 (X=S, Se, Te) materials: Manifestation of metal to semimetal or semiconductor transition
Creators: name: Wasey, A. H. M. Abdul
name: Chakrabarty, Soubhik
name: Das, G. P.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Most of the 2D transition metal dichalcogenides (TMDC) are nonmagnetic in pristine form. However, 2D pristine VX2 (X=S, Se, Te) materials are found to be ferromagnetic. Using spin polarized density functional theory (DFT) calculations, we have studied the electronic, magnetic and surface properties of this class of materials in both trigonal prismatic 2H- and octahedral 1T-phase. Our calculations reveal that they exhibit materially different properties in those two polymorphs. Most importantly, detailed investigation of electronic structure explored the quantum size effect in 2H-phase of these materials thereby leading to metal to semimetal (2H-VS2) or semiconductor (2H-VSe2, 2H-VTe2) transition when downsizing from bilayer to corresponding monolayer.
description: 18 pages, 12 figures, 3 tables
TRBV9 TCR repertoires, Anti-TRBV9 therapy, Case report
Creators: name: Britanova, Olga V.
name: Lupyr, Kseniia R.
name: Staroverov, Dmitry B.
name: Shagina, Irina A.
name: Aleksandrov, Alexey A.
name: Ustyugov, Yakov Y.
name: Somov, Dmitry V.
name: Klimenko, Alesia
name: Shostak, Nadejda A.
name: Zvyagin, Ivan V.
name: V. Stepanov, Alexey
name: Merzlyak, Ekaterina M.
name: Davydov, Alexey N.
name: Izraelson, Mark
name: Egorov, Evgeniy S.
name: Bogdanova, Ekaterina A.
name: Vladimirova, Anna K.
name: Iakovlev, Pavel A.
name: Fedorenko, Denis A.
name: Ivanov, Roman A.
name: Skvortsova, Veronika I.
name: Lukyanov, Sergey A.
name: Chudakov, Dmitry M.
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 320403
subject: Autoimmunity
classificationCode: 320402
subject: Applied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies)

description: Cytotoxic humanized anti-TRBV9 monoclonal antibody. We performed first-in-human targeted depletion of TRBV-restricted T cells in an HLA–B*27-positive patient with AS.TCR repertoiresPreparation of unique molecular identifier (UMI)-labeled TCRβ cDNA libraries was performed using HUMAN TCR RNA MULTIPLEX kit (MiLaboratories) according to the manufacturer's manuals. TRBV9-focused TCRβ cDNA libraries were prepared using an adapted version of the HUMAN TCR RNA MULTIPLEX kit (MiLaboratories).Sequencing was performed on Illumina MiSeq and NextSeq 550, using 150+150 nt paired-end mode. MIGEC v1.2.9 was used for UMI-based read grouping and error correction. MiXCR v3.0.13 was used for extraction of TCRβ CDR3 repertoires. VDJtools v1.2.1 was used for downstream post-analysis. The repertoires include only productive sequences with more than one read per UMI.References[1] Britanova, O.V., Lupyr, K.R., Staroverov, D.B. et al. Targeted depletion of TRBV9+ T cells as immunotherapy in a patient with ankylosing spondylitis. Nat Med (2023). https://doi.org/10.1038/s41591-023-02613-z
title: Cantilever-based ferroelectret energy harvesting
Creators: name: Ben Dali, O.
name: Pondrom, P.
name: Sessler, G. M.
name: Zhukov, S.
name: Seggern, H. von
name: Zhang, X.
name: Kupnik, M.
Publisher: name: AIP Publishing
Year: 2024

description: We present a vibrational energy harvester with fluorinated ethylene propylene (FEP)-ferroelectrets working in d₃₁ mode. The ferroelectret film consists of two FEP films, fused together to form a parallel tunnel structure with well-defined air gaps. Its dynamic piezoelectric g₃₁ coefficient is 0.7V mN⁻¹. The energy-harvesting device is an air-spaced cantilever arrangement that was produced by the additive manufacturing technique. The device was tested by exposing it to sinusoidal vibrations with an acceleration a, generated by a shaker. The measurement shows a resonance at about 35 Hz and a normalized output power of 320 μW for a seismic mass of 4.5 g at an acceleration of 0.1 g (g is the gravity of the earth). This demonstrates a significant improvement of air-spaced vibrational energy harvesting with ferroelectrets and greatly exceeds previous performance data for polymer cantilever devices.
title: Imaging biomarkers for early diagnosis of Alzheimer's disease
Creators: name: Delgado Moraleda, Juan Jose
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Neuroradiology brain
subject: CNS
subject: Head and neck
subject: CAD
subject: MR
subject: Neural networks
subject: Computer Applications-Detection, diagnosis
subject: Computer Applications-General
subject: Segmentation
subject: Dementia
subject: Image registration
subject: Speech disorders

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: ● Propose structures that allow early diagnosis of Alzheimer's disease. ● Obtain a representative sample of Alzheimer’s disease in early states. ● Set imaging biomarkers that allow classify patients in these clinical...
Synthesis, Anticancer and Antimicrobial Screening of New Naphthalenyl-Thiazole and Quinolinyl-Thiazole
Creators: name: Walunj, Yogesh
name: Shinde, Abhijit
name: Borde, Krishna
name: Abhale, Yogita
name: Bobade, Vivek
name: Mhaske, Pravin C.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: A new series of 4-aryl-2-(naphthalen-1-yl)thiazole (7a-b), 4-aryl/pyridyl-2-(2-substituted quinolin-4-yl)thiazole (13a-o) and 4-(pyridin-4-yl)-2-(quinolin-4-yl)thiazole (15) have been synthesized. The newly synthesized compounds were evaluated for anticancer activity against breast cell lines MDA-MB-231 and MCF-7. Among the derivatives compounds 7a, 7 b and 13e showed good activity against the MCF-7 cell line, compounds 13 m, 13o and 15 showed good activity against MDA-MB-231 cell line. The new analogs were also screened to evaluate their in vitro antimicrobial potential against Escherichia coli (NCIM 2574), Proteus mirabilis (NCIM 2388), Bacillus subtilis (NCIM 2063), Staphylococcus albus (NCIM 2178), Aspergillus niger (ATCC 504), and Candida albicans (NCIM 3100). Amongst the naphthalenyl-thiazole and quinolinyl-thiazole derivatives, ten compounds 7a, 7 b, 13a, 13 b, 13c, 13d, 13e, 13f, 13 h and 15 showed good activity against P. mirabilis. The structure-activity relationship study revealed that naphthalene, quinoline, and 2-phenyl quinoline tethered thiazole showed good activity against P. mirabilis. These compounds could assist in the development of lead compounds for the treatment of cancer and microbial infections.
MaNGA DynPop -- I. Quality-assessed stellar dynamical modelling from integral-field spectroscopy of 10K nearby galaxies: a catalogue of masses, mass-to-light ratios, density profiles and dark matter
Creators: name: Zhu, Kai
name: Lu, Shengdong
name: Cappellari, Michele
name: Li, Ran
name: Mao, Shude
name: Gao, Liang
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: This is the first paper in our series on the combined analysis of the Dynamics and stellar Population (DynPop) for the MaNGA survey in the final SDSS Data Release 17 (DR17). Here we present a catalogue of dynamically-determined quantities for over 10000 nearby galaxies based on integral-field stellar kinematics from the MaNGA survey. The dynamical properties are extracted using the axisymmetric Jeans Anisotropic Modelling (JAM) method, which was previously shown to be the most accurate for this kind of study. We assess systematic uncertainties using eight dynamical models with different assumptions. We use two orientations of the velocity ellipsoid: either cylindrically-aligned JAM$_{\rm cyl}$ or spherically-aligned JAM$_{\rm sph}$. We also make four assumptions for the models' dark vs. luminous matter distributions: (1) mass-follows-light, (2) free NFW dark halo, (3) cosmologically-constrained NFW halo, (4) generalized NFW dark halo, i.e. with free inner slope. In this catalogue, we provide the quantities related to the mass distributions (e.g. the density slopes and enclosed mass within a sphere of a given radius for total mass, stellar mass, and dark matter mass components). We also provide the complete models which can be used to compute the full luminous and mass distribution of each galaxy. Additionally, we visually assess the qualities of the models to help with model selections. We estimate the observed scatter in the measured quantities which decreases as expected with improvements in quality. For the best data quality, we find a remarkable consistency of measured quantities between different models, highlighting the robustness of the results.
description: 30 pages, 15 figures, 4 tables, accepted by MNRAS, the catalogue is available here https://manga-dynpop.github.io/
Using Photometry to Probe the Circumstellar Environment of delta Scorpii
Creators: name: Jones, C. E.
name: Wiegert, Paul
name: Tycner, C.
name: Henry, G. W.
name: Cyr, R. P.
name: Halonen, R. J.
name: Muterspaugh, M. W.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We acquired Johnson BV photometry of the binary Be disk system delta~Scorpii during its 2009, 2010, 2011, and 2012 observing seasons and used it to probe the innermost regions of the disk. We found that several disk building events have occurred during this time, resulting in an overall brightening in the V-band and reddening of the system. In addition to these long-term trends, we found cyclical variability in each observing season on timescales between 60 and 100 days. We were able to reproduce the changes in the magnitude and colour of delta Sco using our theoretical models and found that variable mass-loss rates in the range 2.5-7.0x10^{-9} M_{sun}/yr over ~35 days can reproduce the observed increase in brightness.
description: 15 pages, emulateapj
TRBV9 TCR repertoires BCD-180 treatment Case report
Creators: name: Lupyr
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 320403
subject: Autoimmunity
classificationCode: 320402
subject: Applied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies)

description: Therapeutic grade, cytotoxic humanized anti-TRBV9 monoclonal antibody, investigational drug BCD-180, used for the preclinical studies was produced by BIOCAD (https://biocadglobal.com/). We performed first-in-human targeted depletion of TRBV-restricted T cells in an HLA–B*27-positive patient with AS.
 TCR repertoires
 Preparation of unique molecular identifier (UMI)-labeled TCRβ cDNA libraries was performed using HUMAN TCR RNA MULTIPLEX kit (MiLaboratories) according to the manufacturer's manuals. TRBV9-focused TCRβ cDNA libraries were prepared using an adapted version of the HUMAN TCR RNA MULTIPLEX kit (MiLaboratories). Sequencing was performed on Illumina MiSeq and NextSeq 550, using 150+150 nt paired-end mode. MIGEC1 was used for UMI-based read grouping and error correction. MiXCR2 was used for extraction of TCRβ CDR3 repertoires. VDJtools3 was used for downstream post-analysis.The repertoires inclide only productive sequences with more than one read per UMI.
Analyzing the time spectrum of supernova neutrinos to constrain their effective mass or Lorentz Invariance Violation
Creators: name: Moura, C. A.
name: Quintino, L.
name: Rossi-Torres, F.
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We analyze the expected arrival time spectrum of supernova neutrinos using simulated luminosity and compute the expected number of events in future detectors such as the DUNE Far Detector and Hyper-Kamiokande. We develop a general method using minimum square statistics that can compute the sensitivity to any variable affecting neutrino time of flight. We apply this method in two different situations: First, we compare the time spectrum changes due to different neutrino mass values to put limits on electron (anti)neutrino effective mass. Second, we constrain Lorentz invariance violation through the mass scale, $M_{QG}$, at which it would occur. We consider two main neutrino detection techniques: 1. DUNE-like liquid argon TPC, for which the main detection channel is $ν_e +\, ^{40}\mbox{Ar} \rightarrow e^- +\, ^{40}\mbox{K}^*$, related to the supernova neutronization burst; and 2. HyperK-like water Cherenkov detector, for which $\bar ν_e + p \rightarrow e^+ + n$ is the main detection channel. We consider a fixed supernova distance of 10~kpc and two different masses of the progenitor star: (i) 15~$M_\odot$ with neutrino emission time up to 0.3~s and (ii) 11.2~$M_\odot$ with neutrino emission time up to 10~s. The best mass limits at 3$σ$ are for $\mathcal{O}(1)$~eV. For $ν_e$, the best limit comes from a DUNE-like detector if the mass ordering happens to be inverted. For $\bar ν_e$, the best limit comes from a HyperK-like detector. The best limit for the Lorentz invariance violation mass scale at the 3$σ$ level considering a superluminal or subluminal effect is $M_{QG} \gtrsim 10^{13}$~GeV ($M_{QG} \gtrsim 5 \times 10^{5}$~GeV) for linear (quadratic) energy dependence.
description: 18 pages, 11 figures, 7 tables. This version matches the published version on Universe
Algorithmic theory of free solvable groups: randomized computations
Creators: name: Ushakov, Alexander
Publisher: name: arXiv
Year: 2014
Subjects: subject: Group Theory (math.GR)
subject: FOS: Mathematics
subject: 03D15, 20F65, 20F10

description: We design new deterministic and randomized algorithms for computational problems in free solvable groups. In particular, we prove that the word problem and the power problem can be solved in quasi-linear time and the conjugacy problem can be solved in quasi-quartic time by Monte Carlo type algorithms.
title: Aneurysmal Bone Cyst: Intralesional Injection of Calcitonin and Methylprednisolone Treatment
Creators: name: Borges, Danillo
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Neoplasia
subject: Cysts
subject: Treatment effects
subject: Biopsy
subject: Percutaneous
subject: MR
subject: CT
subject: Musculoskeletal bone
subject: Interventional non-vascular

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: In the present study, we report 6 cases of aneurysmal bone cyst treatment with intralesional injection of calcitonin and methylprednisolone, describing their evolution and response to...
New Nanoparticles of Fe3O4@SiO2 Functionalized Sulfonic Acid Magnetic Properties and Catalytic Investigation on the Multi-Component Preparation of Some Organic Compounds
Creators: name: Khalaj, Mehdi
name: Taherkhani, Mahboubeh
name: Kazemi, Malihe Samadi
name: Kalhor, Mehdi
name: Dehkordy, Gelareh Talebian
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Fe3O4@SiO2 functionalized sulfonic acid (FSSA) was prepared by a facile method in three steps and characterized by XRD, FT-IR, SEM-EDX, TGA, UV-Vis, and VSM techniques. The XRD pattern shows the characteristic peaks of the cubic structure of Fe3O4. The presence of sulfonic acid groups was confirmed by FT-IR analysis. FSSA shows reasonable magnetic parameters with good saturation magnetization (Ms = 22.61 memu/g). FSSA was used as a catalyst for the preparation of chromeno[4,3-d]pyrido[1,2-a]pyrimidin derivatives via the condensation of 4-hydroxycoumarin, aldehydes, and 2-aminopyridines under reflux in EtOH (50%) as well as US irradiation. The effect of solvent, temperature, and catalyst dosages on the product formation under reaction conditions was investigated. The effect of various Lewis and Bronsted acid catalysts was compared with FSSA and among different catalysts screened, FSSA was found to have the best efficiency. Next, FSSA was used for the effective and high yielding preparation of 14-aryl-14H-dibenzo[a,j]xanthene derivatives, N-((2-hydroxynaphthalen-1-yl)(aryl)methyl)acetamide derivatives, 2,4,5-triaryl-1H-imidazole derivatives, and 2-amino-5-oxo-4-aryl-4H,5H-pyrano[3,2-c]chromene-3-carbonitrile derivatives. Simple procedure, good yields, and short reaction times, as well as catalyst recovery, are the key advantages of this work.
Loc-Auth: Location-Enabled Authentication Through Attribute-Based Encryption
Creators: name: Portnoi, Marcos
name: Shen, Chien-Chung
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences

description: Traditional user authentication involves entering a username and password into a system. Strong authentication security demands, among other requirements, long, frequently hard-to-remember passwords. Two-factor authentication aids in the security, even though, as a side effect, might worsen user experience. We depict a mobile sign-on scheme that benefits from the dynamic relationship between a user's attributes, the service the user wishes to utilize, and location (where the user is, and what services are available there) as an authentication factor. We demonstrate our scheme employing Bluetooth Low Energy beacons for location awareness and the expressiveness of Attribute-Based Encryption to capture and leverage the described relationship. Bluetooth Low Energy beacons broadcast encrypted messages with encoded access policies. Within range of the beacons, a user with appropriate attributes is able to decrypt the broadcast message and obtain parameters that allow the user to perform a short or simplified login.
description: Accepted at International Conference on Computing, Networking and Communications (ICNC 2015)
Thermoelastic Equation of State of Boron Suboxide B6O up to 6 GPa and 2700 K: Simplified Anderson-Grüneisen Model and Thermodynamic Consistency
Creators: name: Kurakevych, Oleksandr O.
name: Solozhenko, Vladimir L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: p-V-T equation of state of superhard boron suboxide B6O has been measured up to 6 GPa and 2700 K using multianvil technique and synchrotron X-ray diffraction. To fit the experimental data, the theoretical p-V-T equation of state has been derived in approximation of the constant value of the Anderson-Grüneisen parameter δT. The model includes bulk modulus B0 =181 GPa and its first pressure derivative B0' = 6 at 300 K; two parameters describing thermal expansion at 0.1 MPa, i.e. a = 1.4x10-5 K-1 and b = 5x10-9 K-2, as well as δT = 6. The good agreement between fitted and experimental isobars has been achieved to the absolute volume changes up to 5% as compared to volume at standard conditions, V0. The fitted thermal expansion at 0.1 MPa is well consistent with the experimental data, as well as with ambient-pressure heat capacity cp, bulk modulus B0 and δT describing its evolution with volume and temperature. The fitted value of Grüneisen parameter γ = 0.85 is in agreement with previous empiric estimations for B6O and experimental values for other boron-rich solids.
Bulk TCR repertoires, Anti-TRBV9 therapy, Case report
Creators: name: Britanova, Olga V.
name: Lupyr, Kseniia R.
name: Staroverov, Dmitry B.
name: A. Shagina, Irina
name: Aleksandrov, Alexey A.
name: Ustyugov, Yakov Y.
name: Somov, Dmitry V.
name: Klimenko, Alesia
name: Shostak, Nadejda A.
name: Zvyagin, Ivan V.
name: V. Stepanov, Alexey
name: Merzlyak, Ekaterina M.
name: Davydov, Alexey N.
name: Izraelson, Mark
name: Egorov, Evgeniy S.
name: Bogdanova, Ekaterina A.
name: Vladimirova, Anna K.
name: Iakovlev, Pavel A.
name: Fedorenko, Denis A.
name: Ivanov, Roman A.
name: Skvortsova, Veronika I.
name: Lukyanov, Sergey A.
name: Chudakov, Dmitry M.
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 320403
subject: Autoimmunity
classificationCode: 320402
subject: Applied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies)

description: Cytotoxic humanized anti-TRBV9 monoclonal antibody. We performed first-in-human targeted depletion of TRBV-restricted T cells in an HLA–B*27-positive patient with AS.TCR repertoiresPreparation of unique molecular identifier (UMI)-labeled TCRβ cDNA libraries was performed using HUMAN TCR RNA MULTIPLEX kit (MiLaboratories) according to the manufacturer's manuals.Sequencing was performed on Illumina MiSeq and NextSeq 550, using 150+150 nt paired-end mode. MIGEC v1.2.9 was used for UMI-based read grouping and error correction. MiXCR v3.0.13 was used for extraction of TCRβ CDR3 repertoires. VDJtools v1.2.1 was used for downstream post-analysis. The repertoires include only productive sequences with more than one read per UMI.References[1] Britanova, O.V., Lupyr, K.R., Staroverov, D.B. et al. Targeted depletion of TRBV9+ T cells as immunotherapy in a patient with ankylosing spondylitis. Nat Med (2023). https://doi.org/10.1038/s41591-023-02613-z
Exploring Exoplanet Populations with NASA's Kepler Mission
Creators: name: Batalha, Natalie M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The Kepler Mission is exploring the diversity of planets and planetary systems. Its legacy will be a catalog of discoveries sufficient for computing planet occurrence rates as a function of size, orbital period, star-type, and insolation flux. The mission has made significant progress toward achieving that goal. Over 3,500 transiting exoplanets have been identified from the analysis of the first three years of data, 100 of which are in the habitable zone. The catalog has a high reliability rate (85-90% averaged over the period/radius plane) which is improving as follow-up observations continue. Dynamical (e.g. velocimetry and transit timing) and statistical methods have confirmed and characterized hundreds of planets over a large range of sizes and compositions for both single and multiple-star systems. Population studies suggest that planets abound in our galaxy and that small planets are particularly frequent. Here, I report on the progress Kepler has made measuring the prevalence of exoplanets orbiting within 1 AU of their host stars in support of NASA's long-term goal of finding habitable environments beyond the solar system.
description: Invited review (perspective) published in Proceedings of the National Academy of Sciences (PNAS) special issue on Exoplanets. Available online at: http://www.pnas.org/content/111/35/12647.full.pdf+html
Generalist Vision Foundation Models for Medical Imaging: A Case Study of Segment Anything Model on Zero-Shot Medical Segmentation
Creators: name: Shi, Peilun
name: Qiu, Jianing
name: Abaxi, Sai Mu Dalike
name: Wei, Hao
name: Lo, Frank P. -W.
name: Yuan, Wu
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Computer and information sciences

description: In this paper, we examine the recent Segment Anything Model (SAM) on medical images, and report both quantitative and qualitative zero-shot segmentation results on nine medical image segmentation benchmarks, covering various imaging modalities, such as optical coherence tomography (OCT), magnetic resonance imaging (MRI), and computed tomography (CT), as well as different applications including dermatology, ophthalmology, and radiology. Those benchmarks are representative and commonly used in model development. Our experimental results indicate that while SAM presents remarkable segmentation performance on images from the general domain, its zero-shot segmentation ability remains restricted for out-of-distribution images, e.g., medical images. In addition, SAM exhibits inconsistent zero-shot segmentation performance across different unseen medical domains. For certain structured targets, e.g., blood vessels, the zero-shot segmentation of SAM completely failed. In contrast, a simple fine-tuning of it with a small amount of data could lead to remarkable improvement of the segmentation quality, showing the great potential and feasibility of using fine-tuned SAM to achieve accurate medical image segmentation for a precision diagnostics. Our study indicates the versatility of generalist vision foundation models on medical imaging, and their great potential to achieve desired performance through fine-turning and eventually address the challenges associated with accessing large and diverse medical datasets in support of clinical diagnostics.
description: Published in Diagnostics
title: Imaging of appendiceal disease; beyond acute appendicitis
Creators: name: Lee, Gyoung-eun
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Neoplasia
subject: Inflammation
subject: Education
subject: CT
subject: Abdomen
subject: Infection

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: 1. To review the embryology and normal appearance of appendix 2. To demonstrate the spectrum of appendiceal diseases and their imaging...
title: Pre- and post-operative imaging evaluation of the diabetic foot
Creators: name: Lee, Gyoung-eun
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Metabolic disorders
subject: Abscess
subject: Infection
subject: Education
subject: Imaging sequences
subject: MR
subject: Musculoskeletal bone
subject: Musculoskeletal soft tissue

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The purpose of this exhibit is to describe the pathogenesis of diabetic foot and to illustrate magnetic resonance imaging (MRI) findings of diabetic foot and postoperative complication of diabetic...
Proceedings of the 1st Asia-Europe-Pacific School of High-Energy Physics (AEPSHEP 12), Fukuoka, Japan, 14 - 27 Oct 2012
Creators: name: Kawagoe, K.
name: Mulders, M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: The Asia-Europe-Pacific School of High-Energy Physics is intended to give young physicists an introduction to the theoretical aspects of recent advances in elementary particle physics. These proceedings contain lectures on quantum field theory, quantum chromodynamics, flavour physics and CP-violation, physics beyond the Standard Model, neutrino physics, particle cosmology, heavy-ion physics, as well as a presentation of recent results from the Large Hadron Collider (LHC), practical statistics for particle physicists and a short introduction to the principles of particle physics instrumentation.
description: 8 lectures, 285 pages, published as CERN Yellow Report https://cds.cern.ch/record/1443909
title: Sarcopenic diaphragm: measurements with the ultrasound
Creators: name: Demir, Nur Betül
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Musculoskeletal system
subject: Ultrasound
subject: Comparative studies
subject: Geriatrics

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Sarcopenia is age related, involuntary, progressive loss of muscle mass and strength.[1]. Physical inactivity, smoking and poor diet, as well as age-related changes in hormones and cytokine levels are important risk factors for sarcopenia. The...
GAMMA-LIGHT: High-Energy Astrophysics above 10 MeV
Creators: name: Morselli, Aldo
name: Argan, Andrea
name: Barbiellini, Guido
name: Bonvicini, Walter
name: Bulgarelli, Andrea
name: Cardillo, Martina
name: Chen, Andrew
name: Coppi, Paolo
name: Di Giorgio, Anna Maria
name: Donnarumma, Immacolata
name: Del Monte, Ettore
name: Fioretti, Valentina
name: Galli, Marcello
name: Giusti, Manuela
name: Ferrari, Attilio
name: Fuschino, Fabio
name: Giommi, Paolo
name: Giuliani, Andrea
name: Labanti, Claudio
name: Lipari, Paolo
name: Longo, Francesco
name: Marisaldi, Martino
name: Molinari, Sergio
name: Muñoz, Carlos
name: Neubert, Torsten
name: Orleanski, Piotr
name: Paredes, Josep M.
name: Pérez-García, M. Ángeles
name: Piano, Giovanni
name: Picozza, Piergiorgio
name: Pilia, Maura
name: Pittori, Carlotta
name: Pucella, Gianluca
name: Sabatini, Sabina
name: Striani, Edoardo
name: Tavani, Marco
name: Trois, Alessio
name: Vacchi, Andrea
name: Vercellone, Stefano
name: Verrecchia, Francesco
name: Vittorini, Valerio
name: Zdziarski, Andrzej
Publisher: name: arXiv
Year: 2014
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: High-energy phenomena in the cosmos, and in particular processes leading to the emission of gamma- rays in the energy range 10 MeV - 100 GeV, play a very special role in the understanding of our Universe. This energy range is indeed associated with non-thermal phenomena and challenging particle acceleration processes. The technology involved in detecting gamma-rays is challenging and drives our ability to develop improved instruments for a large variety of applications. GAMMA-LIGHT is a Small Mission which aims at an unprecedented advance of our knowledge in many sectors of astrophysical and Earth studies research. The Mission will open a new observational window in the low-energy gamma-ray range 10-50 MeV, and is configured to make substantial advances compared with the previous and current gamma-ray experiments (AGILE and Fermi). The improvement is based on an exquisite angular resolution achieved by GAMMA-LIGHT using state-of-the-art Silicon technology with innovative data acquisition. GAMMA-LIGHT will address all astrophysics issues left open by the current generation of instruments. In particular, the breakthrough angular resolution in the energy range 100 MeV - 1 GeV is crucial to resolve patchy and complex features of diffuse sources in the Galaxy as well as increasing the point source sensitivity. This proposal addresses scientific topics of great interest to the community, with particular emphasis on multifrequency correlation studies involving radio, optical, IR, X-ray, soft gamma-ray and TeV emission. At the end of this decade several new observatories will be operational including LOFAR, SKA, ALMA, HAWK, CTA. GAMMA-LIGHT will "fill the vacuum" in the 10 MeV-10 GeV band, and will provide invaluable data for the understanding of cosmic and terrestrial high-energy sources.
description: 6 pages, 8 figures
title: Thoracic abnormalities after radiation therapy
Creators: name: Lourenco, Ana Luisa
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Lung
subject: Mediastinum
subject: Thorax
subject: CT
subject: Radiation therapy / Oncology
subject: Toxicity
subject: Drugs / Reactions
subject: Cancer

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: Describe and illustrate the most common features related to radiation-induced lung disease, including acute and chronic phase, and their main differential diagnosis; Clarify the importance of PET-CT in distinguish between radiation-induced lung...
Imaging mechanism and contrast separation in low-voltage scanning electron microscopy imaging of carbon nanotube arrays on SiO2/Si substrate
Creators: name: Zhang, Boxiang
name: Zhang, Zhiyong
name: Jin, Chuanhong
Publisher: name: arXiv
Year: 2023
Subjects: subject: Applied Physics (physics.app-ph)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Polymer-sorted high-density carbon nanotube (CNT) arrays have shown great potential to extend the silicon-based Moore's law. Imaging the CNT arrays on insulators like SiO2/Si using low-voltage scanning electron microscopy (LVSEM) to acquire array information like the alignment, density, and distribution of residual polymers is necessary. Such a task remains challenging due to the nanoscale CNT body (1-2 nm in diameter), nanoscale tube-to-tube separation (1-10 nm), the broadening of the apparent diameter, and the complex image contrast caused by the insulating substrate and polymer residues. In this study, the imaging mechanism for this system is investigated. Two methods are developed to separate the three dominant contrasts, i.e. topographic contrast, charge contrast, and material contrast, by selecting the take-off angle and energy of the emitted electrons as enabled by changing the working distance or the deceleration voltage. The contrast formation and separation mechanism is further confirmed by the dynamic contrast evolution due to the electron-beam-induced deposition of amorphous carbon. The contrast separation method is further applied to an individual CNT, reducing its apparent diameter from 36 nm to 6 nm. This result hints at the potential for LVSEM to count the density exceeding 150 CNTs/um of CNT arrays. Finally, a comparative study of LVSEM and transmission electron microscopy confirms the failure of LVSEM to resolve CNTs in a bundle. The results suggest that the density of CNT arrays may be underestimated in reported SEM data. The proposed method can serve as a useful tool for further study and application of arrayed CNTs.
description: 25 pages, 9 figures main text. 5 pages, 6 figures supplementary materials
Bulk TCR repertoires, Anti-TRBV9 therapy, Case report
Creators: name: Britanova, Olga V.
name: Lupyr, Kseniia R.
name: Staroverov, Dmitry B.
name: A. Shagina, Irina
name: Aleksandrov, Alexey A.
name: Ustyugov, Yakov Y.
name: Somov, Dmitry V.
name: Klimenko, Alesia
name: Shostak, Nadejda A.
name: Zvyagin, Ivan V.
name: V. Stepanov, Alexey
name: Merzlyak, Ekaterina M.
name: Davydov, Alexey N.
name: Izraelson, Mark
name: Egorov, Evgeniy S.
name: Bogdanova, Ekaterina A.
name: Vladimirova, Anna K.
name: Iakovlev, Pavel A.
name: Fedorenko, Denis A.
name: Ivanov, Roman A.
name: Skvortsova, Veronika I.
name: Lukyanov, Sergey
name: Chudakov, Dmitry M.
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 320403
subject: Autoimmunity
classificationCode: 320402
subject: Applied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies)

description: Cytotoxic humanized anti-TRBV9 monoclonal antibody. We performed first-in-human targeted depletion of TRBV-restricted T cells in an HLA–B*27-positive patient with AS.
 TCR repertoires
 Preparation of unique molecular identifier (UMI)-labeled TCRβ cDNA libraries was performed using HUMAN TCR RNA MULTIPLEX kit (MiLaboratories) according to the manufacturer's manuals.
 Sequencing was performed on Illumina MiSeq and NextSeq 550, using 150+150 nt paired-end mode. MIGEC was used for UMI-based read grouping and error correction. MiXCR was used for extraction of TCRβ CDR3 repertoires. VDJtools was used for downstream post-analysis.The repertoires inclide only productive sequences with more than one read per UMI.
title: Spectrum of musculoskeletal findings in hyperparathyroidism
Creators: name: Amante, Sofia
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Head and neck
subject: Kidney
subject: Musculoskeletal bone
subject: Conventional radiography
subject: CT
subject: Complications
subject: Endocrine disorders
subject: Osteoporosis

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To review the types of hyperparathyroidism and its pathophysiology; To recognize imaging features and findings of hyperparathyroidism in the musculoskeletal system, with some examples of computed tomography (CT) and principal emphasis on...
Macaca mulatta, Anti-TRBV9 therapy
Creators: name: Britanova, Olga V.
name: Lupyr, Kseniia R.
name: Staroverov, Dmitry B.
name: A. Shagina, Irina
name: Aleksandrov, Alexey A.
name: Ustyugov, Yakov Y.
name: Somov, Dmitry V.
name: Klimenko, Alesia
name: Shostak, Nadejda A.
name: Zvyagin, Ivan V.
name: V. Stepanov, Alexey
name: Merzlyak, Ekaterina M.
name: Davydov, Alexey N.
name: Izraelson, Mark
name: Egorov, Evgeniy S.
name: Bogdanova, Ekaterina A.
name: Vladimirova, Anna K.
name: Iakovlev, Pavel A.
name: Fedorenko, Denis A.
name: Ivanov, Roman A.
name: Skvortsova, Veronika I.
name: Lukyanov, Sergey A.
name: Chudakov, Dmitry M.
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 320402
subject: Applied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies)
classificationCode: 320403
subject: Autoimmunity

description: Cytotoxic humanized anti-TRBV9 monoclonal antibody. A single intravenous (i.v.) dose of the antibody administered to rhesus macaques (Macaca mulatta), resulted in prominent depletion of peripheral blood TRBV9+ T cells in a dose-dependent manner.AnimalsAfter quarantine, 12 Macaca mulatta males aged 5–8 years were selected for this experiment. For TCR repertoire profiling peripheral blood samples were collected before and 3, 40, 150, and 300 days after a single administration of BCD-180. We divided the animals into two groups (n = 4 for each group) that received 1 mg or 10 mg BCD-180 i.v. per animal, along with a control group that included four animals and received human intravenous IgG immunoglobulins (Microgen). Animals were kept in accordance with the guidelines for accommodation and care of laboratory animals, with species-specific provisions for nonhuman primates. The local ethics committee approved experiments for these studies.TCR repertoiresSequencing was performed on Illumina HiSeq1500. MIGEC v1.2.9 was used for UMI-based read grouping and error correction. MiXCR v3.0.13 was used for extraction of TCRβ CDR3 repertoires. VDJtools v1.2.1 was used for downstream post-analysis. The repertoires include only productive sequences with more than one read per UMI.References[1] Britanova, O.V., Lupyr, K.R., Staroverov, D.B. et al. Targeted depletion of TRBV9+ T cells as immunotherapy in a patient with ankylosing spondylitis. Nat Med (2023). https://doi.org/10.1038/s41591-023-02613-z
Tidal Forcing on the Sun and the 11-year Solar Activity Cycle
Creators: name: Cionco, Rodolfo G.
name: Kudryavtsev, Sergey M.
name: Soon, Willie
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The hypothesis that tidal forces on the Sun are related to the modulations of the solar-activity cycle has gained increasing attention. The works proposing physical mechanisms of planetary action via tidal forcing have in common that quasi-alignments between Venus, Earth, and Jupiter (V-E-J configurations) would provide a basic periodicity of $\approx 11.0$ years able to synchronize the operation of solar dynamo with these planetary configurations. Nevertheless, the evidence behind this particular tidal forcing is still controversial. In this context we develop, for the first time, the complete Sun's tide-generating potential (STGP) in terms of a harmonic series, where the effects of different planets on the STGP are clearly separated and identified. We use a modification of the spectral analysis method devised by Kudryavtsev (J. Geodesy. 77, 829, 2004; Astron. Astrophys. 471, 1069, 2007b) that permits to expand any function of planetary coordinates to a harmonic series over long time intervals. We build a catalog of 713 harmonic terms able to represent the STGP with a high degree of precision. We look for tidal forcings related to V-E-J configurations and specifically the existence of periodicities around $11.0$ years. Although the obtained tidal periods range from $\approx$ 1000 years to 1 week, we do not find any $\approx$ 11.0 years period. The V-E-J configurations do not produce any significant tidal term at this or other periods. The Venus tidal interaction is absent in the 11-year spectral band, which is dominated by Jupiter's orbital motion. The planet that contributes the most to the STGP in three planets configurations, along with Venus and Earth, is Saturn. An $\approx 11.0$ years tidal period with a direct physical relevance on the 11-year-like solar-activity cycle is highly improbable.
description: (May 2023) Published in Solar Physics
title: All roads lead to R..ight atrium: general review of congenital anomalies of the systemic venous return
Creators: name: Oliveira, João Diogo
Publisher: name: European Congress of Radiology
Year: 2018
Subjects: subject: Education and training
subject: Normal variants
subject: MR-Angiography
subject: CT-Angiography
subject: CT
subject: Veins / Vena cava
subject: Cardiovascular system
subject: Anatomy

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To review the normal anatomy of the systemic venous return. To understand the basics of the embryology of the venous system. To acknowledge and recognize the most common congenital anomalies of the systemic venous return to the right...
Beratung von Sozialhilfebezüger*innen zum Thema Wohnen: Rechtliche Rahmenbedingungen und Herausforderungen aus der Perspektive von Fachpersonen des Kantons Luzern
Creators: name: Lüscher, Alicia
Publisher: name: Hochschule Luzern – Soziale Arbeit
Year: 2024

description: Diese Bachelorarbeit mit dem Titel «Beratung von Sozialhilfebezüger*innen zum Thema Wohnen - Rechtliche Rahmenbedingungen und Herausforderungen aus der Perspektive von Fachpersonen des Kantons Luzern» untersucht die Komplexität der Beratung im Bereich Wohnen innerhalb der Sozialhilfe und beleuchtet die spezifischen Herausforderungen. Die Arbeit beginnt mit einer theoretischen Einführung in die Sozialhilfe, das Recht auf Wohnen und die sozialarbeiterischen Aufgaben, um eine Basis für die folgenden Analysen zu schaffen.

Die zentrale Fragestellung der Arbeit fokussiert sich auf die Herausforderungen, die durch Fachpersonen in den Sozialämtern und in Sozialberatungszentren bei der Unterstützung von Sozialhilfebezüger*innen im Bereich Wohnen bemerkt werden. Die Arbeit erforscht, wie diese Fachpersonen mit den Herausforderungen umgehen und welche Strategien sie entwickeln, um den komplexen Anforderungen gerecht zu werden. 

Zur Beantwortung dieser Fragen wurden sechs Leitfadeninterviews mit Expert*innen aus der wirtschaftlichen Sozialhilfe im Kanton Luzern durchgeführt. Diese Expert*innen agieren als Sozialarbeitende in Gemeinden oder einem Gemeindeverband oder als Sozialvorsteher*innen der Gemeinden. Die Interviews bieten Einblick in die Herausforderungen und die rechtlichen Rahmenbedingungen, welche die Beratungen und Begleitungen durch die Fachpersonen im Bereich Wohnen betreffen. Die Ergebnisse der Forschung werden im Rahmen des dreifachen Mandats der Sozialen Arbeit mit der Theorie verknüpft.

Insgesamt liefert die Arbeit wertvolle Erkenntnisse über die Interaktion zwischen rechtlichen Vorschriften und den alltäglichen Herausforderungen der Sozialarbeit im Bereich Wohnen und trägt zudem zur Verbesserung des Verständnisses und zur Verbesserung der praktischen Handhabung bei.
description: + Code Diss LU: hslusa basa + Fussnote: Bachelor-Arbeit, Hochschule Luzern – Soziale Arbeit, Studienrichtung Sozialarbeit, 2024 + NL-Code: NLLUHSA202409