Abdominal obesity‐related disturbance of insulin sensitivity is associated with cd8+ emra cells in the elderly
Creators: name: Boßlau, Tim K.
name: Wasserfurth, Paulina
name: Krüger, Britta
name: Reichel, Thoma
name: Palmowski, Jana
name: Nebl, Josefine
name: Weyh, Christopher
name: Schenk, Alexander
name: Joisten, Niklas
name: Stahl, Frank
name: Thoms, Stefanie
name: Gebhardt, Kristina
name: Hahn, Andreas
name: Krüger, Karsten
Publisher: name: Basel : MDPI
Year: 2021
Subjects: subject: Elderly
subject: Insulin resistance
subject: Kynurenine pathway
subject: Obesity
subject: T‐EMRA cells
subject: adipocytokine
subject: adiponectin
subject: cytokine
subject: fractalkine
subject: glucose
subject: hemoglobin A1c
subject: insulin
subject: interleukin 1 receptor blocking agent
subject: interleukin 15
subject: interleukin 1beta
subject: interleukin 6
subject: kynurenine
subject: resistin
subject: tryptophan
subject: tumor necrosis factor
subject: biological marker
subject: receptor type tyrosine protein phosphatase C
subject: abdominal obesity
subject: adult
subject: Article
subject: blood sampling
subject: body composition
subject: body mass
subject: body weight
subject: CD8+ T lymphocyte
subject: cross-sectional study
subject: Cytomegalovirus
subject: enzyme linked immunosorbent assay
subject: female
subject: flow cytometry
subject: glucose metabolism
subject: hip circumference
subject: HOMA index
subject: homeostasis model assessment
subject: human
subject: human experiment
subject: insulin resistance
subject: insulin sensitivity
subject: major clinical study
subject: male
subject: middle aged
subject: normal human
subject: peripheral blood mononuclear cell
subject: T lymphocyte subpopulation
subject: tryptophan metabolism
subject: waist circumference
subject: waist hip ratio
subject: blood
subject: case control study
subject: immunological memory
subject: immunology
subject: metabolism
subject: pathophysiology
subject: Adipokines
subject: Biomarkers
subject: Body Mass Index
subject: Case-Control Studies
subject: CD8-Positive T-Lymphocytes
subject: Cross-Sectional Studies
subject: Cytokines
subject: Female
subject: Humans
subject: Immunologic Memory
subject: Insulin Resistance
subject: Kynurenine
subject: Leukocyte Common Antigens
subject: Male
subject: Middle Aged
subject: Obesity, Abdominal
subject: Tryptophan
subject: Dewey Decimal Classification::500 | Naturwissenschaften::570 | Biowissenschaften, Biologie

description: Aging and overweight increase the risk of developing type 2 diabetes mellitus. In this cross‐sectional study, we aimed to investigate the potential mediating role of T‐EMRA cells and inflammatory markers in the development of a decreased insulin sensitivity. A total of 134 healthy older volunteers were recruited (age 59.2 (SD 5.6) years). T cell subpopulations were analyzed by flow cytometry. Furthermore, body composition, HOMA‐IR, plasma tryptophan (Trp) metabolites, as well as cytokines and adipokines were determined. Using subgroup and covariance analyses, the influence of BMI on the parameters was evaluated. Moreover, correlation, multiple regression, and mediation analyses were performed. In the subgroup of participants with obesity, an increased proportion of CD8+EMRA cells and elevated concentrations of plasma kynurenine (KYN) were found compared to the lower‐weight subgroups. Linear regression analysis revealed that an elevated HOMA‐IR could be predicted by a higher proportion of CD8+EMRA cells and KYN levels. A mediation analysis showed a robust indirect effect of the Waist‐to‐hip ratio on HOMA‐IR mediated by CD8+EMRA cells. Thus, the deleterious effects of abdominal obesity on glucose metabolism might be mediated by CD8+EMRA cells in the elderly. Longitudinal studies should validate this assumption and analyze the suitability of CD8+EMRA cells as early predictors of incipient prediabetes. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.