cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Lettre n°205 de Paul d'Estournelles de Constant à Nicholas Murray Butler (3 janvier 1917)
title: Letter number 205 from Paul d'Estournelles de Constant to Nicholas Murray Butler (January 3, 1917)
Creators: name: d'Estournelles de Constant, Paul
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2022
Subjects: Pacifisme
Guerre mondiale (1914-1918)

description: Source: Archives de la Sarthe – France
Saturation rate after vaccination against covid-19
Creators: name: Mohr, Arno
name: Hitzenbichler, Florian
name: Pfeifer, Michael
name: Hinterberger, Thilo
name: Loew, Thomas H.
name: Leinberger, Beate
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: COVID-19; Dyspnoea; Saturation; Vaccination
subject: 610 Medizin

description: Introduction:
Cormirnaty® was the first available vaccine in Europe that contains mRNA encoding the spike protein of SARS-CoV2. An enormous peptide commonality and thus molecular mimicry between SARS-CoV2 spike protein and human proteins could be shown. Molecular mimicry could be attributable to SARS-CoV2 associated illness.

Objectives: 
So far saturation rate was not examined in patients who received Cormirnaty®. A decline in saturation rate would be suggestive that main reason for respiratory failure in patients with COVID-19 is the immune response to the spike protein.

Method: 
The study was conducted at the Centre of Pneumology in Donaustauf, Germany. Employees that qualified for vaccination against COVID-19 and who were willing to be vaccinated with Cormirnaty® (second dose) were asked to participate in this study. Participants were asked to measure saturation rate three times a day for seven days after vaccination.

Results: 
106 participants (84 female, 22 male) were included into the analysis. Mean oxygenation satur-ation measured directly after vaccination was 97.4% (max 99%, min 93%. During days two to five, mean oxygen saturation dropped to 97.2% (max 99%, min 83%). This difference was significant in a one-tailed signed rank test with z=-1.88 (p=0.030).

Conclusion: 
A mild but significant decline in satu-ration could be detected. As Cormirnaty® comprises mRNA for encoding peptides of the spike protein the decline in saturation rate might hint that molecular mimicry is an important element of COVID-19.
Characterization report for developed coatings - Deliverable D4.3
Creators: name: Balbo Andrea
Publisher: name: Zenodo
Year: 2023
Subjects: PROCRAFT
Cultural Heritage
Aircraft
WWII
Aluminium Alloy
Duralumin
Protection
Aviation Archaeology

description: This document reports the complete characterization of the protective systems within the WP4 - Development of protective coating for outdoor exposure.
CLASSIFICATION OF LEVELS OF VIRTUAL REALITY MOTION SICKNESS USING MACHINE LEARNING – ASSESSMENT AND MITIGATION
Creators: name: SHYLAJA P
name: JAYASUDHA J S
Publisher: name: Zenodo
Year: 2024
Subjects: Classification, EEG, Lime, Machine Learning, Motion Sickness, Virtual Reality.

description: Abstract

Virtual Reality applications are getting attention in fields like industry, education, healthcare, manufacturing, training etc. Engaging people in a 360-degree world with a head-mounted device may cause physical and health problems.  Many people cannot use Virtual Reality devices seamlessly because of motion sickness problems. Complex graphical properties included in the scene make to feel more sickness for Virtual Reality users. Virtual Reality movements include various types of geometrical transformations such as yaw, pitch, roll, rotation, translation, scaling, shearing and transformation. Study shows that continuous involvement in a VR environment starts to show symptoms of motion sickness. The motion sickness can be measured using EEG signals. Many researchers contributed to the motion sickness detection for binary classification but there are few numbers on multi-level classification and the existing has less accuracy too. Our proposed model did multi-level classification on standard EEG data and got an accuracy of 98.82% and lime local explanation has also done in this paper.
Structural Analysis of Mitochondrial Dynamics—From Cardiomyocytes to Osteoblasts: A Critical Review
Creators: name: Mendelsohn, Daniel H.
name: Schnabel, Katja
name: Mamilos, Andreas
name: Sossalla, Samuel
name: Pabel, Steffen
name: Duerr, Georg Daniel
name: Keller, Karsten
name: Schmitt, Volker H.
name: Barsch, Friedrich
name: Walter, Nike
name: Wong, Ronald Man Yeung
name: El Khassawna, Thaqif
name: Niedermair, Tanja
name: Alt, Volker
name: Rupp, Markus
name: Brochhausen, Christoph
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: mitochondria; fission; fusion; ultrastructure; heart; bone; hypoxia; inflammation
subject: 610 Medizin

description: Mitochondria play a crucial role in cell physiology and pathophysiology. In this context, mitochondrial dynamics and, subsequently, mitochondrial ultrastructure have increasingly become hot topics in modern research, with a focus on mitochondrial fission and fusion. Thus, the dynamics of mitochondria in several diseases have been intensively investigated, especially with a view to developing new promising treatment options. However, the majority of recent studies are performed in highly energy-dependent tissues, such as cardiac, hepatic, and neuronal tissues. In contrast, publications on mitochondrial dynamics from the orthopedic or trauma fields are quite rare, even if there are common cellular mechanisms in cardiovascular and bone tissue, especially regarding bone infection. The present report summarizes the spectrum of mitochondrial alterations in the cardiovascular system and compares it to the state of knowledge in the musculoskeletal system. The present paper summarizes recent knowledge regarding mitochondrial dynamics and gives a short, but not exhaustive, overview of its regulation via fission and fusion. Furthermore, the article highlights hypoxia and its accompanying increased mitochondrial fission as a possible link between cardiac ischemia and inflammatory diseases of the bone, such as osteomyelitis. This opens new innovative perspectives not only for the understanding of cellular pathomechanisms in osteomyelitis but also for potential new treatment options.
Peromyscus pembertoni Burt 1932
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Peromyscus
Peromyscus pembertoni

description: Peromyscus pembertoni Burt 1932
Peromyscus pembertoni Burt 1932, Trans. San Diego Soc. Nat. Hist., 7: 176.
Type Locality: México, Sonora, San Pedro Nolasco Isl; 27°58'N, 111°24'W.
Vernacular Names: Pemberton's Deermouse.
Distribution: Known only from the type locality.
Conservation: IUCN – Extinct.
Discussion: P. eremicus species group. Derivation from a P. merriami -like ancestor postulated by Lawlor (1971a). Probably extinct—see Lawlor (1983) and Alvarez-Castañeda and Ortega-Rubio (2003). See Alvarez-Castañeda and Cortés-Calva (2003, Mammalian Species, 734).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1076, DOI: 10.5281/zenodo.7316535
Additional file 1 of Pre-hospital management of penetrating neck injuries: derivation of an algorithm through a National Modified Delphi
Creators: name: Simpson, Christopher
name: Tucker, Harriet
name: Griggs, Joanne
name: Gavrilovski, Maja
name: Lyon, Richard
name: Hudson, Anthony
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Supplementary file 1
Ostraca from Bu Njem 74-99
Creators: name: Marichal, Robert
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015

description: vue 2
description: Annotations, transcription and photos.
description: Source: 4MAR_15_2.7-11-10
description: Coverage: Bu Njem
description: created: n. d.
Identification and Isolation of Type II NKT Cell Subsets in Human Blood and Liver
Creators: name: Yang Zhou, Jordi
name: Werner, Jens M.
name: Glehr, Gunther
name: Geissler, Edward K.
name: Hutchinson, James A.
name: Kronenberg, Katharina
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: T-CELLS; PLZF; HEALTH; NKT; isolation; expansion; FoxP3; liver; steatotic
subject: 610 Medizin

description: Background: Steatotic livers are more prone to rejection, but are often transplanted owing to the shortage of available organs. Type II NKT (T2NKT) cells are liver-resident lymphocytes that react to lipids presented by CD1d. The role of T2NKT cells in rejection of fatty liver transplants is unclear, partly because of a lack of T2NKT cell markers and their very low frequency in blood. Here, we quantify human T2NKT cells in blood and liver tissue by flow cytometry and provide a strategy for their enrichment and expansion. Methods: Human T2NKT cells were identified as CD3(+) CD56(+) CD161(+) TCR-gamma delta(-), TCRV alpha 7.2(-) and TCRV alpha 24(-) cells. T2NKT cells were enriched from blood by sequential positive selection using CD56 and CD3 microbeads. These were subsequently FACS-sorted to purity then expanded in vitro for 3 weeks using anti-CD3/CD28 beads and TGF-beta 1. Results: The frequency of human T2NKT cells in blood was very low (0.8 +/- 0.4% of CD3(+) T cells) but they were a more abundant population in liver (6.3 +/- 0.9%). Enriched T2NKT cells expressed the transcription factor PLZF. A novel subset of FoxP3(+) T2NKT cells was discovered in blood and liver tissue. T2NKT cells were expanded in culture by 15- to 28-fold over 3 weeks, during which time they maintained expression of all identifying markers, including PLZF and FoxP3. Conclusions: Our work defines new strategies for identifying and isolating T2NKT cells from human blood and liver tissue. We showed that this rare population can be expanded in vitro in order to obtain experimentally amenable cell numbers. Further, we identified a novel T2NKT cell subset that stably expresses FoxP3, which might play a role in regulating innate-like lymphocyte responses in steatotic liver transplants.
Euonthophagus Balthasar 1959
Creators: name: Ziani, Stefano
name: Abdel-Dayem, Mahmoud Saleh
name: Aldhafer, Hathal Mohammed
name: Barbero, Enrico
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Scarabaeidae
Euonthophagus

description: Genus Euonthophagus Balthasar, 1959
Remarks. Onthophagus carbonarius Klug, 1855, O. maindroni d’Orbigny, 1898 and O. yemenicus Balthasar, 1946 have been placed in Euonthophagus by Balthasar (1963), probably for the presence on the head of only one transverse carina in male or a middle tubercle in female, not homologous either with the clypeofrontal carina or the occipital one, and located either at the middle of the head or slightly forward of the middle. On the basis of the morphology of the male genital armature, in the first two species at least, this placement does not seem to have a phylogenetic basis. Most probably O. carbonarius and O. maindroni belong to two different phylogenetic groups. Kabakov (2006) inserted O. carbonarius in the subgenus Colobonthophagus Balthasar, 1963, but not even this nomenclatorial act seems to be satisfactory. The placement of the three species is in great need of further study, and until such time we provisionally leave them in Euonthophagus.
description: Published as part of Ziani, Stefano, Abdel-Dayem, Mahmoud Saleh, Aldhafer, Hathal Mohammed & Barbero, Enrico, 2019, An overview of the Onthophagini from the Arabian Peninsula (Coleoptera: Scarabaeoidea: Scarabaeidae), pp. 1-36 in Zootaxa 4658 (1) on page 6, DOI: 10.11646/zootaxa.4658.1.1, http://zenodo.org/record/3373040
Advanced Immune Cell Profiling by Multiparameter Flow Cytometry in Humanized Patient-Derived Tumor Mice
Creators: name: Bruss, Christina
name: Kellner, Kerstin
name: Ortmann, Olaf
name: Seitz, Stephan
name: Brockhoff, Gero
name: Hutchinson, James A.
name: Wege, Anja Kathrin
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: REGULATORY T-CELLS; HLA CLASS-I; MOUSE MODEL; HUMAN B; ANTI-PD-1 ANTIBODY; RESPONSES; BLOCKADE; THERAPY; PD-1; VIVO; humanized tumor mice (HTM); humanized patient-derived xenograft (hPDX); breast cancer; hematopoietic stem cells (HSC); multicolor flow cytometry; immunotherapy
subject: 610 Medizin

description: Simple Summary Immunotherapies have revolutionized the field of oncology and have been approved to treat cancer. Despite progress in immunotherapy, many challenges remain, including the identification (i) of predictive markers for treatment response or (ii) of beneficial T cell subsets involved in tumor elimination. "Humanized" mice are a promising translational model for studying the human immune system in the context of immuno-oncology research. Here, multicolor flow cytometry was applied to characterize immune cell subsets in the spleen of humanized mice transplanted with patient-derived breast cancer tissues. This multicolor immune cell setup will help to identify promising therapeutic approaches or predictive immune cell subsets in the future using humanized tumor mice. "Humanized" mice have been widely used for the characterization of human cancer progression and as a powerful preclinical model. Standardization of multicolor phenotyping could help to identify immune cell patterns involved in checkpoint-related complications. Therefore, we applied established protocols for immune cell profiling to our humanized Patient-Derived Xenograft (hPDX) model. hPDX are characterized by the co-existence of a human immune system and a patient-derived tumor transplant. These mice possess a human-like immune system after CD34(+) stem cell transplantation while the reconstitution level of the immune system was not related to the quantity of transplanted CD34(+) cells. Contamination <= 1.2% by CD3(+) cells in the hematopoietic stem cell (HSC) transplant did not trigger abnormal T cell maturation. Different B and T cell differentiation stages were identified, as well as regulatory T cells (Tregs) and exhausted T cells that expressed TIGIT, PD-1, or KLRG1. Overall, the application of standardized protocols for the characterization of immune cells using flow cytometry will contribute to a better understanding of immune-oncologic processes.
Case Report: Extramedullary Acute Promyelocytic Leukemia: An Unusual Case and Mini-Review of the Literature
Creators: name: Heudobler, Daniel
name: Harrer, Dennis Christoph
name: Lüke, Florian
name: Einspieler, Ingo
name: Menhart, Karin
name: Hellwig, Dirk
name: Utpatel, Kirsten
name: Herr, Wolfgang
name: Reichle, Albrecht
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: acute promyelocytic leukemia, chloroma, myeloid sarcoma, PML-RARA rearrangement, normal blood counts
subject: 610 Medizin

description: Background: 
Acute promyelocytic leukemia (APL) constitutes a serious hematological emergency necessitating rapid diagnosis and therapy to prevent lethal bleedings resulting from APL-induced thrombocytopenia and coagulopathy. Atypical manifestations of APL, such as extramedullary disease at first presentation, pose diagnostic challenges and delay the onset of appropriate therapy. Nevertheless, extramedullary manifestations of APL are mostly accompanied by blood count alterations pointing to an underlying hematological disease. In this report, we present the first case of APL bearing close resemblance to a metastasized laryngeal carcinoma with normal blood counts and absent coagulopathy.

Case Presentation: 
A 67-year-old man with a previous history of smoking was admitted to our hospital with progressive hoarseness of voice, odynophagia, dysphagia and exertional dyspnea. Laryngoscopy revealed a fixed right hemi larynx with an immobile right vocal fold. Imaging of the neck via magnetic-resonance imaging (MRI) and positron emission tomography–computed tomography (PET/CT) with F-18-fluordeoxyglucose (FDG) showed a large hypermetabolic tumor in the right piriform sinus and tracer uptake in adjacent lymph nodes, highly suspicious of metastasized laryngeal carcinoma. Surprisingly the histological examination revealed an extramedullary manifestation of acute promyelocytic leukemia. Remarkably, blood counts and coagulation parameters were normal. Moreover, no clinical signs of hemorrhage were found. PML-RARA fusion was detected in both laryngeal mass and bone marrow. After diagnosis of APL, ATRA-based chemotherapy was initiated resulting in complete remission of all APL manifestations.

Conclusions: 
This is the first case report of APL initially presenting as laryngeal chloroma. Additionally, we performed a comprehensive literature review of previously published extramedullary APL manifestations. In aggregate, a normal blood count at first presentation constitutes an extremely rare finding in patients initially presenting with extramedullary APL manifestations.
Peromyscus perfulvus Osgood 1945
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Peromyscus
Peromyscus perfulvus

description: Peromyscus perfulvus Osgood 1945
Peromyscus perfulvus Osgood 1945, J. Mammal., 26: 299.
Type Locality: México, Michoacán, 10 km W Apatzingán, 1040 ft (317 m).
Vernacular Names: Tawny Deermouse.
Synonyms: Peromyscus chrysopus Hooper 1955.
Distribution: Coastal lowlands of Jalisco and Colima, along Río Balsas to interior Michocán and northernmost Guerrero, México.
Conservation: IUCN – Lower Risk (lc).
Discussion: P. melanophrys species group. Placed with P. melanophrys group by Hooper (1968), an association supported by electrophoretic data (Schmidly et al., 1985). The geographic range and ecological affinity of P. perfulvus and Osgoodomys banderanus are tightly congruent and suggest similar biogeographic histories.
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1076, DOI: 10.5281/zenodo.7316535
Peromyscus polionotus Wagner 1843
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Peromyscus
Peromyscus polionotus

description: Peromyscus polionotus Wagner 1843
Peromyscus polionotus Wagner 1843, Arch. Naturgesch., 9 (2): 52.
Type Locality: USA, Georgia.
Vernacular Names: Oldfield Deermouse.
Synonyms: Peromyscus albifrons Osgood 1909; Peromyscus allophrys Bowen 1968; Peromyscus ammobates Bowen 1968; Peromyscus arenarius Bangs 1898; Peromyscus baliolus Bangs 1898; Peromyscus colemani Schwartz 1954; Peromyscus decoloratus A. H. Howell 1939; Peromyscus griseobracatus Bowen 1968; Peromyscus leucocephalus A. H. Howell 1920; Peromyscus lucubrans Schwartz 1954; Peromyscus niveiventris (Chapman 1889); Peromyscus peninsularis A. H. Howell 1939; Peromyscus phasma Bangs 1898; Peromyscus rhoadsi Bangs 1898; Peromyscus subgriseus (Chapman 1893); Peromyscus sumneri Bowen 1968; Peromyscus trissyllepsis Bowen 1968.
Distribution: SE USA, from SC Tennessee to W South Carolina, south through Alabama and Georgia, to panhandle and N peninsular Florida, USA.
Conservation: U.S. ESA – Endangered as P. p. allophrys, P. p. ammobates, P. p. peninsularis, P. p. phasma, and P. p. trissyllepsis, Threatened and as P. p. niveiventris; IUCN – Extinct as P. p. decoloratus, Critically Endangered as P. p. trissyllepsis, Endangered as P. p. allophrys, P. p. ammobates, P. p. peninsularis, and P. p. phasma, Lower Risk (nt) as P. p. leucocephalus and P. p. niveiventris, otherwise Lower Risk (lc).
Discussion: P. maniculatus species group. Revised by Osgood (1909). Pleistocene origination of subspecies hypothesized by Bowen (1968); intraspecific genetic differentiation surveyed by Selander et al. (1971). See commentary on subspecific variation and ranges by Whitaker and Hamilton (1998), who considered colemani and subgriseus as inseparable from the nominate subspecies. Membership within maniculatus group and relationships to other Peromyscus assessed by Avise et al. (1979), Greenbaum et al. (1978), Rogers et al. (1984), and Stangl and Baker (1984 b).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1076, DOI: 10.5281/zenodo.7316535
Vitronectin and Its Interaction with PAI-1 Suggests a Functional Link to Vascular Changes in AMD Pathobiology
Creators: name: Biasella, Fabiola
name: Strunz, Tobias
name: Kiel, Christina
name: Weber, Bernhard H. F.
name: Friedrich, Ulrike
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: PLASMINOGEN-ACTIVATOR INHIBITOR-1; GENOME-WIDE ASSOCIATION; MACULAR DEGENERATION; EXTRACELLULAR-MATRIX; ENDOTHELIAL-CELLS; GENE-EXPRESSION; BINDING-SITE; HUMAN-PLASMA; RPE CELLS; PROTEIN; AMD; age-related macular degeneration; vitronectin; VTN; rs704; SERPINE1; PAI-1; neovascularization
subject: 610 Medizin

description: The pathogenesis of age-related macular degeneration (AMD), a frequent disorder of the central retina, is incompletely understood. Genome-wide association studies (GWAS) suggest a strong contribution of genomic variation in AMD susceptibility. Nevertheless, little is known about biological mechanisms of the disease. We reported previously that the AMD-associated polymorphism rs704C > T in the vitronectin (VTN) gene influences protein expression and functional aspects of encoded vitronectin, a human blood and extracellular matrix (ECM) protein. Here, we refined the association of rs704 with AMD in 16,144 cases and 17,832 controls and noted that rs704 is carried exclusively by the neovascular AMD subtype. Interaction studies demonstrate that rs704 affects the ability of vitronectin to bind the angiogenic regulator plasminogen activator inhibitor 1 (PAI-1) but has no influence on stabilizing its active state. Western blot analysis and confocal imaging reveal a strong enrichment of PAI-1 in the ECM of cultured endothelial cells and RPE cell line ARPE-19 exposed to vitronectin. Large-scale gene expression of VTN and PAI-1 showed positive correlations and a statistically significant increase in human retinal and blood tissues aged 60 years and older. Our results suggest a mechanism by which the AMD-associated rs704 variant in combination with ageing may contribute to the vascular complications in AMD.
Additional file 1 of Exploring the ’EarSwitch’ concept: a novel ear based control method for assistive technology
Creators: name: Hoyle, Anna C.
name: Stevenson, Richard
name: Leonhardt, Martin
name: Gillett, Thomas
name: Martinez-Hernandez, Uriel
name: Gompertz, Nick
name: Clarke, Christopher
name: Cazzola, Dario
name: Metcalfe, Benjamin W.
Publisher: name: figshare
Year: 2024
Subjects: subject: Neuroscience
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: Supplementary file 1.
Ostraca from Bu Njem
Creators: name: Marichal, Robert
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015

description: vue 40
description: Maps and photos with annotations. - Offprint of Y. LE BOHEC, Un nouveau type d'unité connu par l'épigraphie africaine, Actes du XIIè Congrès des Limes (1979-1980), 945-955 (2 copies). - R. REBUFFAT, 'Le limes' de Tripolitaine, «Town and country in Roman Tripolitania» BAR (1980), 127-141. - J. REYNOLDS, Roman inscriptions 1971-1975, "JRS" 66 (1976), 190-192.
description: Source: 4MAR_15_2.7-11-31
description: Coverage: Bu Njem##Libya
description: created: n. d.
Additional file 2 of Exploring the ’EarSwitch’ concept: a novel ear based control method for assistive technology
Creators: name: Hoyle, Anna C.
name: Stevenson, Richard
name: Leonhardt, Martin
name: Gillett, Thomas
name: Martinez-Hernandez, Uriel
name: Gompertz, Nick
name: Clarke, Christopher
name: Cazzola, Dario
name: Metcalfe, Benjamin W.
Publisher: name: figshare
Year: 2024
Subjects: subject: Neuroscience
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: Supplementary file 2.
Inhibitory effects of calcium or magnesium ions on PDI
Creators: name: Eckl, Daniel Bernhard
name: Landgraf, Nicole
name: Hoffmann, Anja Karen
name: Schottenhaml, Laura
name: Dirscherl, Julia
name: Weber, Nina
name: Eben, Stefanie Susanne
name: Bäßler, Pauline
name: Eichner, Anja
name: Huber, Harald
name: Bäumler, Wolfgang
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: Photodynamic inactivation, Divalent ions, Magnesium, Calcium, Photosensitizers
subject: 570 Biowissenschaften, Biologie
subject: 610 Medizin

description: Photodynamic inactivation of microorganisms (PDI) finds use in a variety of applications. Several studies report on substances enhancing or inhibiting PDI. In this study, we analyzed the inhibitory potential of ubiquitous salts like CaCl2 and MgCl2 on PDI against Staphylococcus aureus and Pseudomonas aeruginosa cells using five cationic photosensitizers methylene blue, TMPyP, SAPYR, FLASH-02a and FLASH-06a.
TMPyP changed its molecular structure when exposed to MgCl2, most likely due to complexation. CaCl2 substantially affected singlet oxygen generation by MB at small concentrations. Elevated concentrations of CaCl2 and MgCl2 impaired PDI up to a total loss of bacterial reduction, whereas CaCl2 is more detrimental for PDI than MgCl2. Binding assays cannot not explain the differences of PDI efficacy. It is assumed that divalent ions tightly bind to bacterial cells hindering close binding of the photosensitizers to the membranes. Consequently, photosensitizer binding might be shifted to outer compartments like teichoic acids in Gram-positives or outer sugar moieties of the LPS in Gram-negatives, attenuating the oxidative damage of susceptible cellular structures.
In conclusion, CaCl2 and MgCl2 have an inhibitory potential at different phases in PDI. These effects should be considered when using PDI in an environment that contains such salts like in tap water or different fields of food industry.
Freimuth, Heinz-Gert: Gotteserfahrung in der Musik
Creators: name: Gierlich, Fr.
Publisher: name: Ordenskorrespondenz
Year: 1970

description: Ordenskorrespondenz, Bd. 26 (1985): Ordenskorrespondenz: Zeitschrift für Fragen des Ordenslebens, Band 26
A Bayesian Model of Underreporting for Sexual Assault on College Campuses
Creators: name: Bradshaw, Casey
name: Blei, David M.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: In an effort to quantify and combat sexual assault, US colleges and universities are required to disclose the number of reported sexual assaults on their campuses each year. However, many instances of sexual assault are never reported to authorities, and consequently the number of reported assaults does not fully reflect the true total number of assaults that occurred; the reported values could arise from many combinations of reporting rate and true incidence. In this paper we estimate these underlying quantities via a hierarchical Bayesian model of the reported number of assaults. We use informative priors, based on national crime statistics, to act as a tiebreaker to help distinguish between reporting rates and incidence. We outline a Hamiltonian Monte Carlo (HMC) sampling scheme for posterior inference regarding reporting rates and assault incidence at each school, and apply this method to campus sexual assault data from 2014-2019. Results suggest an increasing trend in reporting rates for the overall college population during this time. However, the extent of underreporting varies widely across schools. That variation has implications for how individual schools should interpret their reported crime statistics.
Additional file 6 of Exploring the ’EarSwitch’ concept: a novel ear based control method for assistive technology
Creators: name: Hoyle, Anna C.
name: Stevenson, Richard
name: Leonhardt, Martin
name: Gillett, Thomas
name: Martinez-Hernandez, Uriel
name: Gompertz, Nick
name: Clarke, Christopher
name: Cazzola, Dario
name: Metcalfe, Benjamin W.
Publisher: name: figshare
Year: 2024
Subjects: subject: Neuroscience
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: Supplementary file 6.
Methodology for the nocturnal cardiac arrhythmia ancillary study of the ADVENT-HF trial in patients with heart failure with reduced ejection fraction and sleep-disordered breathing
Creators: name: Horvath, Christian M.
name: Fisser, Christoph
name: Douglas Bradley, T.
name: Floras, John S.
name: Sossalla, Samuel
name: Parati, Gianfranco
name: Zeman, Florian
name: Castiglioni, Paolo
name: Faini, Andrea
name: Rankin, Fiona
name: Arzt, Michael
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: Heart failure, Premature ventricular complex, Premature atrial complex, Sleep-disordered breathing, Inter-observer reliability, Methods, ADVENT-HF
subject: 610 Medizin

description: Background
Sleep disordered breathing (SDB) may trigger nocturnal cardiac arrhythmias (NCA) in patients with heart failure with reduced ejection fraction (HFrEF). The NCA ancillary study of the ADVENT-HF trial will test whether, in HFrEF-patients with SDB, peak-flow-triggered adaptive servo-ventilation (ASVpf) reduces NCA. To this end, accurate scoring of NCA from polysomnography (PSG) is required.
Objective
To develop a method to detect NCA accurately from a single-lead electrocardiogram (ECG) recorded during PSG and assess inter-observer agreement for NCA detection.
Methods
Quality assurance of ECG analysis included training of the investigators, development of standardized technical quality, guideline-conforming semi-automated NCA-scoring via Holter-ECG software and implementation of an arrhythmia adjudication committee. To assess inter-observer agreement, the ECG was analysed by two independent investigators and compared for agreement on premature ventricular complexes (PVC) /h, premature atrial complexes/h (PAC) as well as for other NCA in 62 patients from two centers of the ADVENT-HF trial.
Results
The intraclass correlation coefficients for PVC/h and PAC/h were excellent: 0.99 (95%- confidence interval [CI]: 0.99–0.99) and 0.99 (95%-CI: 0.97–0.99), respectively. No clinically relevant difference in inter-observer classification of other NCA was found. The detection of non-sustained ventricular tachycardia (18% versus 19%) and atrial fibrillation (10% versus 11%) was similar between the two investigators. No sustained ventricular tachycardia was detected.
Conclusion
These findings indicate that our methods are very reliable for scoring NCAs and are adequate to apply for the entire PSG data set of the ADVENT-HF trial.
Mitrapsylla compta Burckhardt & Queiroz
Creators: name: Rendón-Mera, Diana Isabel
name: Burckhardt, Daniel
name: Cavichioli, Rodney R.
name: Queiroz, Dalva L.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Psyllidae
Mitrapsylla
Mitrapsylla compta

description: Mitrapsylla compta Burckhardt & Queiroz
LSID: urn:lsid:zoobank.org:act: 0C6549FF-4079-40C2-8066-A6E5996EF029
Mitrapsylla compta Burckhardt & Queiroz, 2020: 39. Holotype ♁, Brazil: Piauí, Brasileira / Piracuruca, Parque Nacional de Sete Cidades, -4.0733, -41.6800, 130–210 m, 21–24.vi.2016, Cerrado vegetation with open areas and more humid areas around pond, Copaifera cearensis (D. Burckhardt & D.L. Queiroz), #201(5) (MZSP, dry) (examined).
Description of adult by Burckhardt & Queiroz (2020). Immature unknown.
Distribution. Brazil (Piauí) (Burckhardt & Queiroz 2020).
Host-plant. Adults were collected on Copaifera cearensis Ducke (Leguminosae, Detarioideae, Detarieae) which is a likely host (Burckhardt & Queiroz 2020).
description: Published as part of Rendón-Mera, Diana Isabel, Burckhardt, Daniel, Cavichioli, Rodney R. & Queiroz, Dalva L., 2020, Taxonomy and host-plant relationships of the psyllid genus Mitrapsylla (Hemiptera: Psylloidea: Psyllidae) in Brazil, pp. 1-100 in Zootaxa 4887 (1) on page 30, DOI: 10.11646/zootaxa.4887.1.1, http://zenodo.org/record/4297565
Additional file 1 of Clinical profile of Korean children with spina bifida: a single-center prospective cohort study
Creators: name: Yun, Hyeseon
name: Yang, Seung Hyeon
name: Lee, Hooyun
name: Kim, Sang Woon
name: Lee, Yong Seung
name: Ji, Yoonhye
name: Park, Jieun
name: Ji, Jeong-Eun
name: Choi, Eun Kyoung
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy

description: Supplementary Material 1.
Immunometabolic Markers in a Small Patient Cohort Undergoing Immunotherapy
Creators: name: Hofbauer, Joshua
name: Hauck, Andreas
name: Matos, Carina
name: Babl, Nathalie
name: Decking, Sonja-Maria
name: Rechenmacher, Michael
name: Schulz, Christian
name: Regotta, Sabine
name: Mickler, Marion
name: Haferkamp, Sebastian
name: Siska, Peter J.
name: Herr, Wolfgang
name: Renner, Kathrin
name: Kreutz, Marina
name: Schnell, Annette
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: CELL LUNG-CANCER; CHOLESTEROL; CD147; NIVOLUMAB; COMBINATION; BIOMARKERS; CACHEXIA; PD-1; immunotherapy; PD-1+ monocytes; metabolism; hormones; immune cells; cholesterol; testosterone; free androgen index; hemoglobin
subject: 610 Medizin

description: Although the discovery of immune checkpoints was hailed as a major breakthrough in cancer therapy, generating a sufficient response to immunotherapy is still limited. Thus, the objective of this exploratory, hypothesis-generating study was to identify potentially novel peripheral biomarkers and discuss the possible predictive relevance of combining scarcely investigated metabolic and hormonal markers with immune subsets. Sixteen markers that differed significantly between responders and non-responders were identified. In a further step, the correlation with progression-free survival (PFS) and false discovery correction (Benjamini and Hochberg) revealed potential predictive roles for the immune subset absolute lymphocyte count (rs = 0.51; p = 0.0224 *), absolute basophil count (rs = 0.43; p = 0.04 *), PD-1+ monocytes (rs = -0.49; p = 0.04 *), hemoglobin (rs = 0.44; p = 0.04 *), metabolic markers LDL (rs = 0.53; p = 0.0224 *), free androgen index (rs = 0.57; p = 0.0224 *) and CRP (rs = -0.46; p = 0.0352 *). The absolute lymphocyte count, LDL and free androgen index were the most significant individual markers, and combining the immune subsets with the metabolic markers into a biomarker ratio enhanced correlation with PFS (rs = -0.74; p <= 0.0001 ****). In summary, in addition to well-established markers, we identified PD-1+ monocytes and the free androgen index as potentially novel peripheral markers in the context of immunotherapy. Furthermore, the combination of immune subsets with metabolic and hormonal markers may have the potential to enhance the power of future predictive scores and should, therefore, be investigated further in larger trials.
Peromyscus polius Osgood 1904
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Peromyscus
Peromyscus polius

description: Peromyscus polius Osgood 1904
Peromyscus polius Osgood 1904, Proc. Biol. Soc. Wash., 17: 61.
Type Locality: México, Chihuahua, Colonia García.
Vernacular Names: Chihuahuan Deermouse.
Distribution: WC Chihuahua, México.
Conservation: IUCN – Vulnerable.
Discussion: Species group indeterminate. A distinctive species of enigmatic relationships: initially placed with the truei group (Osgood, 1909) but provisionally reassigned to the boylii group by Hoffmeister (1951; also see Bradley and Schmidly, 1987, and commentary by Anderson, 1972:348). Allozymic distance data weakly support the latter association (Bradley et al., 1996; Kilpatrick and Zimmerman, 1975; Schmidly et al., 1985), but mitochondrial DNA (cytochrome b) interpretations of its kinship are inconclusive (Tiemann-Boege et al., 2000).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1076, DOI: 10.5281/zenodo.7316535
Rifampicin restores extracellular organic matrix formation and mineralization of osteoblasts after intracellular Staphylococcus aureus infection
Creators: name: Alagboso, Francisca I.
name: Mannala, Gopala K.
name: Walter, Nike
name: Docheva, Denitsa
name: Brochhausen, Christoph
name: Alt, Volker
name: Rupp, Markus
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: ONCOLOGY CLASSIFICATION-SYSTEM; PROSTHETIC JOINT INFECTION; PROTEIN-A; CELL-LINE; KAPPA-B; BONE; INTERNALIZATION; BINDING; PROLIFERATION; GENTAMICIN; Staphylococcus aureus; Osteoblast; Metabolism; Mineralization; Rifampicin
subject: 610 Medizin

description: Aims Bone regeneration during treatment of staphylococcal bone infection is challenging due to the ability of Staphylococcus aureus to invade and persist within osteoblasts. Here, we sought to determine whether the metabolic and extracellular organic matrix formation and mineralization ability of S. aureus- infected human osteoblasts can be restored after rifampicin (RMP) therapy. Methods The human osteoblast- like Saos- 2 cells infected with S. aureus EDCC 5055 strain and treated with 8 mu g/ml RMP underwent osteogenic stimulation for up to 21 days. Test groups were Saos- 2 cells + S. aureus and Saos- 2 cells + S. aureus + 8 mu g/ml RMP, and control groups were uninfected untreated Saos- 2 cells and uninfected Saos- 2 cells + 8 mu g/ml RMP. Results The S. aureus- infected osteoblasts showed a significant number of intracellular bacteria colonies and an unusual higher metabolic activity (p < 0.005) compared to uninfected osteoblasts. Treatment with 8 mu g/ml RMP significantly eradicated intracellular bacteria and the metabolic activity was comparable to uninfected groups. The RMP-treated infected osteoblasts revealed a significantly reduced amount of mineralized extracellular matrix (ECM) at seven days osteogenesis relative to uninfected untreated osteoblasts (p = 0.007). Prolonged osteogenesis and RMP treatment at 21 days significantly improved the ECM mineralization level. Ultrastructural images of the mineralized RMP-treated infected osteoblasts revealed viable osteoblasts and densely distributed calcium crystal deposits within the extracellular organic matrix. The expression levels of prominent bone formation genes were comparable to the RMP-treated uninfected osteoblasts. Conclusion Intracellular S. aureus infection impaired osteoblast metabolism and function. However, treatment with low dosage of RMP eradicated the intracellular S. aureus, enabling extracellular organic matrix formation and mineralization of osteoblasts at later stage.
title: Activité du port de Saint-Malo – 1689 – Erquy
Creators: name: :Unkn
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: produits agroalimentaires
subject: céréales
subject: matériaux de construction

description: Cette fiche est issue de l’enquête menée par Jean Delumeau sur l’activité du port de Saint-Malo au 17e et 18e siècle. Cette fiche correspond à l’activité de l’année 1689 avec le port "Erquy"
description: Marchandises arrivées à Saint-Malo : blé ; bois
description: Catégories de marchandises arrivées à Saint-Malo : produits agroalimentaires ; céréales ; matériaux de construction
description: Coverage: Petit cabotage
description: Bibliographic citation: MONIMART, Jacques. Essai sur le trafic marchand de Saint-Malo en 1688 et 1689 : le commerce malouin à la veille et au début de la guerre de la Ligue d'Augsbourg. DES : Histoire : Rennes, s.d. (Bibliothèque François-Lebrun, MH 1004)
description: date: Date de numérisation : 2021 à 2023
description: created: Années 1950-1960
Loss of Polycystin-1 causes cAMP-dependent switch from tubule to cyst formation
Creators: name: Scholz, Julia Katharina
name: Kraus, Andre
name: Lüder, Dominik
name: Skoczynski, Kathrin
name: Schiffer, Mario
name: Schödel, Johannes
name: Buchholz, Björn
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: 610 Medizin

description: Autosomal dominant polycystic kidney disease is the most common monogenic disease that causes end-stage renal failure. It primarily results from mutations in the PKD1 gene that encodes for Polycystin-1. How loss of Polycystin-1 translates into bilateral renal cyst development is mostly unknown. cAMP is significantly involved in cyst enlargement but its role in cyst initiation has remained elusive. Deletion of Polycystin-1 in collecting duct cells resulted in a switch from tubule to cyst formation and was accompanied by an increase in cAMP. Pharmacological elevation of cAMP in Polycystin 1-competent cells caused cyst formation, impaired plasticity, nondirectional migration, and mis-orientation, and thus strongly resembled the phenotype of Polycystin-1-deficient cells. Mis-orientation of developing tubule cells in metanephric kidneys upon loss of Polycystin-1 was phenocopied by pharmacological increase of cAMP in wildtype kidneys. In vitro, cAMP impaired tubule formation after capillary-induced injury which was further impaired by loss Polycystin-1.
Peromyscus pseudocrinitus Burt 1932
Creators: name: Wilson, Don E.
name: Reeder, DeeAnn
Publisher: name: The Johns Hopkins University Press
Year: 2005
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Rodentia
Cricetidae
Peromyscus
Peromyscus pseudocrinitus

description: Peromyscus pseudocrinitus Burt 1932
Peromyscus pseudocrinitus Burt 1932, Trans. San Diego Soc. Nat. Hist., 7: 173.
Type Locality: México, Baja California Sur, Coronados Isl; 26°06'N, 111°18'W.
Vernacular Names: Coronados Deermouse.
Distribution: Known only from the type locality.
Conservation: IUCN – Critically Endangered.
Discussion: P. eremicus species group. Tentatively allocated to crinitus species group by Hooper (1968); affinities to P. eremicus asserted by Lawlor (1971 a) and believed derived therefrom (Lawlor, 1983). See Alvarez-Castañeda (1998, Mammalian Species, 601).
description: Published as part of Wilson, Don E. & Reeder, DeeAnn, 2005, Order Rodentia - Family Cricetidae, pp. 955-1189 in Mammal Species of the World: a Taxonomic and Geographic Reference (3 rd Edition), Volume 2, Baltimore :The Johns Hopkins University Press on page 1077, DOI: 10.5281/zenodo.7316535
Mitrapsylla copaiferae Burckhardt & Queiroz
Creators: name: Rendón-Mera, Diana Isabel
name: Burckhardt, Daniel
name: Cavichioli, Rodney R.
name: Queiroz, Dalva L.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hemiptera
Psyllidae
Mitrapsylla
Mitrapsylla copaiferae

description: Mitrapsylla copaiferae Burckhardt & Queiroz
LSID: urn:lsid:zoobank.org:act: C1A90C1E-3BA3-4F91-9D96-93075F160B7E
Mitrapsylla copaiferae Burckhardt & Queiroz, 2020: 40. Holotype ♁, Brazil: Minas Gerais, Vargem Bonita, Parque Nacional da Serra da Canastra, Cachoeira Casca d’Anta, around park entrance, -20.3083, -46.5217, 850–860 m, 4–8.ix.2014, transition from riparian to Cerrado vegetation, Copaifera langsdorffii (D. Burckhardt & D.L. Queiroz), #141(4) (MZSP, dry) (examined).
Material examined. São Paulo: 1 ♀, Araraquara, Fazenda Cambuhy, 12.ix.2006, citrus grove, suction trap (P. Yamamoto) (FSCA, 70% ethanol); 1 ♀, same but 24.xi.2006 (P. Yamamoto) (FSCA, 70% ethanol); 1 ♁, 1 ♀, same but 27.ix.2007 (P. Yamamoto) (FSCA, 70% ethanol); 1 ♁, 1 ♀, Matão, Fazenda Marchesan, 21.x.2005, citrus grove, suction trap (P. Yamamoto) (FSCA, 70% ethanol); 1 ♀, same but 24.vii.2006 (P. Yamamoto) (FSCA, 70% ethanol); 2 ♀, same but 3.ix.2007 (P. Yamamoto) (FSCA, 70% ethanol); 1 ♁, same but 17.ix.2007 (P. Yamamoto) (FSCA, 70% ethanol); 1 ♁, 1 ♀, same but 3.iv.2008 (P. Yamamoto) (FSCA, 70% ethanol); 1 ♁, 1 ♀, same but 20.ix.2008 (P. Yamamoto) (FSCA, 70% ethanol).
Description of adult and last instar immature by Burckhardt & Queiroz (2020).
Distribution. Brazil (Goiás, Mato Grosso, Mato Grosso do Sul, Minas Gerais, S„o Paulo) (Burckhardt & Queiroz 2020).
Host-plant. Copaifera langsdorffii Desf. and perhaps C. oblongifolia Mart. (Leguminosae, Detarioideae, Detarieae) (Burckhardt & Queiroz 2020).
description: Published as part of Rendón-Mera, Diana Isabel, Burckhardt, Daniel, Cavichioli, Rodney R. & Queiroz, Dalva L., 2020, Taxonomy and host-plant relationships of the psyllid genus Mitrapsylla (Hemiptera: Psylloidea: Psyllidae) in Brazil, pp. 1-100 in Zootaxa 4887 (1) on pages 30-31, DOI: 10.11646/zootaxa.4887.1.1, http://zenodo.org/record/4297565
Foliaro nº 26 (Ĉinio nº 8) (p. 32)
Creators: name: Péraire, Lucien
name: CNRS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023

description: Mi renkontas Ĉinon kun estas eksbatalanto en Francio de milito 1914-18
HuH-7-Lunet BLR Cells Propagate Rat Hepatitis E Virus (HEV) in a Cell Culture System Optimized for HEV
Creators: name: Schemmerer, Mathias
name: Erl, Monika
name: Wenzel, Jürgen J.
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: ; rat HEV; Orthohepevirus C; hepatitis E virus; zoonosis; cell culture
subject: 610 Medizin

description: The family Hepeviridae comprises the species Orthohepevirus A-D (HEV-A to -D). HEV-C genotype 1 (HEV-C1, rat HEV) is able to infect humans. This study investigated whether an optimized HEV-A cell culture system is able to propagate the cell culture-derived rat HEV, and if de novo isolation of the virus from rat liver is possible. We tested the liver carcinoma cell lines PLC/PRF/5, HuH-7, and HuH-7-Lunet BLR for their susceptibility to HEV-C1 strains. Cells were infected with the cell culture-derived HEV-C1 strain R63 and rat liver-derived strain R68. Cells were maintained in MEMM medium, which was refreshed every 3-4 days. The viral load of HEV-C1 was determined by RT-qPCR in the supernatant and expressed as genome copies per mL (c/mL). Rat HEV replication was most efficient in the newly introduced HuH-7-Lunet BLR cell line. Even if the rat HEV isolate had been pre-adapted to PLC/PRF/5 by multiple passages, replication in HuH-7-Lunet BLR was still at least equally effective. Only HuH-7-Lunet BLR cells were susceptible to the isolation of HEV-C1 from the liver homogenate. These results suggest HuH-7-Lunet BLR as the most permissive cell line for rat HEV. Our HEV-C1 cell culture system may be useful for basic research, the animal-free generation of large amounts of the virus as well as for the testing of antiviral compounds and drugs.