cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A New Solution of Einstein Vacuum Field Equations
Creators: name: Vishwakarma, Ram Gopal
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: A new solution of Einstein's vacuum field equations is discovered which appears as a generalization of the well-known Ozsvath-Schucking solution and explains its source of curvature which has otherwise remained hidden. Curiously, the new solution has a vanishing Kretschmann scalar and is singularity-free despite being curved. The discovery of the new solution is facilitated by a new insight which reveals that it is always possible to define the source of curvature in a vacuum solution in terms of some dimensional parameters. As the parameters vanish, so does the curvature. The new insight also helps to make the vacuum solutions Machian.
description: Pramana - J. Phys. (in press)
The Epstein-Barr virus (EBV) BMRF1 promoter for early antigen (EA-D) is regulated by the EBV transactivators, BRLF1 and BZLF1, in a cell-specific manner.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: The Epstein-Barr virus early antigen diffuse component (EA-D) is essential for Epstein-Barr virus DNA polymerase activity, and its activity is suppressed during latent infection. We investigated the regulation of the promoter (BMRF1) for this early gene by studying its responsiveness in vitro to two immediate-early viral transactivators, BZLF1 (Z) and BRLF1 (R), focusing on the differences in response in lymphoid cells and epithelial cells. In lymphoid cells, Z or R alone produced only small increases in EA-D promoter activity, whereas both transactivators together produced a large stimulatory effect. In epithelial cells, the Z transactivator alone produced maximal stimulation of the EA-D promoter; the effect of R and Z together was no greater than that of Z alone. Deletional analysis and site-directed mutagenesis of the EA-D promoter demonstrated that in epithelial cells the potential AP-1 binding site plays an essential role in Z responsiveness, although sequences further upstream are also important. In lymphoid cells, only the upstream sequences are required for transactivation by the Z/R combination, and the AP-1 site is dispensable. These data suggest that EA-D (BMRF1) promoter regulation by Z and R is cell type specific and appears to involve different mechanisms in each cell type.
Estimation of spatio-temporal variability in land surface temperature over the Ganga River Basin using MODIS data
Creators: name: Mal, Suraj
name: Rani, Seema
name: Maharana, Pyarimohan
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: The present study aims to estimate the trends in daytime land surface temperature (LST) and its relationship with other parameters such as elevation and land use/land cover (LULC) over the Ganga River Basin (GRB) during 2001–2019. The study examined monthly daytime clear-sky LST, elevation, LULC, snow cover area (SCA), clear-sky days, and aerosols data of the GRB. Annual mean clear-sky daytime LST has been declining at the rate −0.017 °C year−1 over the basin during the study period. At seasonal scale, LST has been rising during monsoon (average rate of 0.026 °C year−1), whereas other seasons show a decline with the highest magnitude during winter season (−0.078, oC year−1). The study observed pronounced warming trends (0.003 to 0.07 °C year−1) in post-monsoon above the elevation of 3000 m amsl indicating elevation-dependent warming (EDW) in the basin. The vagary in LST over the basin may be attributed to the changes in LULC, increasing aerosols loading, and rising hazy days.
Application of Sentinel-1 data in mapping land-use and land cover in a complex seasonal landscape: a case study in coastal area of Vietnamese Mekong Delta
Creators: name: Pham, Luan Hong
name: Pham, Lien T. H.
name: Dang, Thanh Duc
name: Tran, Dung Duc
name: Dinh, Toan Quang
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Science Policy
subject: Plant Biology

description: The advent of Sentinel-1 SAR data with high temporal and medium spatial resolutions along with its being unaffected by presence of cloud provided opportunities for using remote sensing in mapping LULCs with high temporal detail. The objective of this study is to explore the possibility of applying Sentinel-1 data together with OBIA and machine learning in classifying LULC in a complex agricultural landscape in the coastal area of Vietnamese Mekong Delta (VMD). Three approaches including Sentinel-1 alone, integrative Sentinel-1 and Sentinel-2 and lastly, only Sentinel-2 were deployed to examine chance of improvement of classification accuracy metrics on using Sentinel-1 data. The result showed that SAR data could capture seasonal patterns of different LULC classes. Also, supplementing Sentinel-1 can improve classification overall accuracy especially on integrating with optical data. However, Sentinel-1-alone approach performed poorly in most of LULC cases and bias of optical data can compromise classification accuracy of integrative approach.
Heterogeneous nucleation of/on nanoparticles: a density functional study using the phase-field crystal model
Creators: name: Gránásy, László
name: Podmaniczky, Frigyes
name: Tóth, Gyula I.
name: Tegze, György
name: Pusztai, Tamás
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Crystallization of supersaturated liquids usually starts by heterogeneous nucleation. Mounting evidence shows that even homogeneous nucleation in simple liquids takes place in two steps; first a dense amorphous precursor forms, and the crystalline phase appears via heterogeneous nucleation in/on the precursor cluster. Herein, we review recent results by a simple dynamical density functional theory, the phase-field crystal model, for (precursor-mediated) homogeneous and heterogeneous nucleation of nanocrystals. It will be shown that the mismatch between the lattice constants of the nucleating crystal and the substrate plays a decisive role in determining the contact angle and nucleation barrier, which were found to be non-monotonic functions of the lattice mismatch. Time dependent studies are essential as investigations based on equilibrium properties often cannot identify the preferred nucleation pathways. Modeling of these phenomena is essential for designing materials on the basis of controlled nucleation and/or nano-patterning.
Destruction of superconductivity in disordered materials : a dimensional crossover
Creators: name: Crauste, O.
name: Couëdo, F.
name: Bergé, L.
name: Marrache-Kikuchi, C. A.
name: Dumoulin, L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: The disorder-induced Superconductor-to-Insulator Transition in amorphous Nb$_{x}$Si$_{1-x}$ two-dimensional thin films is studied for different niobium compositions $x$ through a variation of the sample thickness $d$. We show that the critical thickness $d_c$, separating a superconducting regime from an insulating one, increases strongly with diminishing $x$, thus attaining values of over 100 Å. The corresponding phase diagram in the $(d, x)$ plane is inferred and related to the three-dimensional situation. The two-dimensional Superconductor-to-Insulator Transition well connects with the three-dimensional Superconductor-to-Metal Transition.
The Epstein-Barr virus BRLF1 immediate-early gene product transactivates the human immunodeficiency virus type 1 long terminal repeat by a mechanism which is enhancer independent.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1990

description: The Epstein-Barr virus (EBV) immediate-early gene product, BRLF1, transactivates the human immunodeficiency virus type 1 (HIV-1) long terminal repeat. BRLF1-induced transactivation of HIV-1 promoter constructs is accompanied by an increase in plasmid mRNA and is reporter gene independent. Previously, BRLF1 transactivation of EBV promoters has been mapped to regions which function as enhancer elements. Deletional analysis demonstrates that BRLF1 transactivation of the HIV-1 promoter does not require the HIV-1 enhancer. Thus, the EBV BRLF1 gene product may transactivate by at least two different mechanisms, one mechanism involving certain enhancer elements and another mechanism which is enhancer independent.
The factorization method for a defective region in an anisotropic material
Creators: name: Cakoni, Fioralba
name: Harris, Isaac
Publisher: name: arXiv
Year: 2014
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 78A46 35J05

description: In this paper we consider the inverse acoustic scattering (in \mathbb{R}^3) or electromagnetic scattering (in \mathbb{R}^2, for the scalar TE-polarization case) problem of reconstructing possibly multiple defective penetrable regions in a known anisotropic material of compact support. We develop the factorization method for a non-absorbing anisotropic background media containing penetrable defects. In particular, under appropriate assumptions on the anisotropic material properties of the media we develop a rigorous characterization for the support of the defective regions from the given far field measurements. Finally we present some numerical examples in the two dimensional case to demonstrate the feasibility of our reconstruction method including examples for the case when the defects are voids (i.e. subregions with refractive index the same as the background outside the inhomogeneous hosting media).
Physical random bit generation from chaotic solitary laser diode
Creators: name: Virte, Martin
name: Mercier, Emeric
name: Thienpont, Hugo
name: Panajotov, Krassimir
name: Sciamanna, Marc
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optics (physics.optics)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: We demonstrate the physical generation of random bits at high bit rates (> 100 Gb/s) using optical chaos from a solitary laser diode and therefore without the complex addition of either external optical feedback or injection. This striking result is obtained despite the low dimension and relatively small bandwidth of the laser chaos, i.e. two characteristics that have been so far considered as limiting the performances of optical chaos-based applications. We unambiguously attribute the successful randomness at high speed to the physics of the laser chaotic polarization dynamics and the resulting growth rate of the dynamical entropy.
description: 14 pages, 3 figures, submitted
EBNA-2 transactivates a lymphoid-specific enhancer in the BamHI C promoter of Epstein-Barr virus.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: Among the few Epstein-Barr virus (EBV) genes expressed during latency are the Epstein-Barr nuclear antigens (EBNAs), at least one of which contributes to the ability of the virus to transform B lymphocytes. We have analyzed a promoter located in the BamHI-C fragment of EBV which is responsible for the expression of EBNA-1 in some cell lines. Deletion analysis of a 1.4-kb region 5' of the RNA start site has identified a 700-bp fragment that is required for optimal promoter activity in latently infected B lymphocytes, as shown by promoter constructs linked to the chloramphenicol acetyltransferase reporter gene. This fragment is also able to enhance activity, in an orientation-independent manner, of the simian virus 40 early promoter linked to the chloramphenicol acetyltransferase gene. The enhancer element has some constitutive activity in EBV-negative lymphoid cells, which is increased in the presence of the EBNA-2 gene product. Further deletions have shown that the EBNA-2-responsive region requires a 98-bp region that contains a degenerate octamer-binding motif. In epithelial cells there was no enhancer activity regardless of the presence of EBNA-2. These results demonstrate that BamHI-C promoter activity may be dependent not on an enhancer contained in the ori-P, as was previously assumed, but rather on EBNA-2 transactivation of this more proximal enhancer located in the upstream region of the BamHI C promoter itself.
Epstein-Barr virus infection in carcinoma of the salivary gland.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: Undifferentiated carcinoma of the parotid gland contains clonal Epstein-Barr virus episomes without ladder arrays of restriction enzyme fragments representing virion DNA. Analysis of Epstein-Barr virus transcription in situ in parotid carcinoma specimens revealed that the EBER RNAs, latent membrane protein mRNA, and the BamHI-A rightward reading frame, BARF0, are expressed in the malignant epithelial cells.
Multiple Parton Interactions with ALICE: from pp to p-Pb
Creators: name: Morsch, Andreas
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The study of multiplicity dependent di-hadron angular correlations allows us to assess the contribution of multiple-parton interactions to particle production. We will review these measurements in pp and p-Pb collisions with the ALICE detector at the LHC and discuss the results in the context of centrality determination and other multiplicity dependent observables in p-Pb.
description: 9 pages, 10 figures; Invited talk presented at the 30th Winter Workshop on Nuclear Dynamics (WWND 2014), Galveston, Texas, USA, April 6-12, 2014
Expression of the Epstein-Barr virus BamHI A fragment in nasopharyngeal carcinoma: evidence for a viral protein expressed in vivo.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: A family of mRNAs that are transcribed rightward through the BamHI A fragment have been detected in C15, a nasopharyngeal carcinoma (NPC) which has been passaged in nude mice. Northern (RNA) blot hybridizations indicate that these RNAs are also expressed in three other NPCs which have been established in nude mice and in an NPC obtained at biopsy. Moreover, hybridization in situ detected transcription from BamHI A in 12 NPCs and 1 Epstein-Barr virus (EBV)-containing carcinoma of the parotid gland. In each case, transcription was detected in all of the malignant epithelial cells. Transcription was not detected in two cases of EBV-positive lymphoma biopsies by in situ hybridization nor in latently infected EBV-positive lymphoblastoid cell lines by Northern blot hybridization. The consistent transcription of these sequences in latently infected epithelial malignancy but not in lymphoid cells suggests that this viral function is associated with latent EBV infection of epithelial cells. Sequence analysis of a cDNA synthesized from the C15 tumor, representing the 3' end of BamHI A messenger RNA, revealed an open reading frame (ORF). Translation of this ORF in vitro produced several peptides that were immunoprecipitated with antisera from patients with NPC. The detection of antibodies to the protein encoded by the ORF present in the BamHI A cDNA indicates that BamHI A encodes a protein which is expressed in vivo and is antigenic.
Inventory and GLOF hazard assessment of glacial lakes in the Sikkim Himalayas, India
Creators: name: Islam, Nazimul
name: Patel, Priyank Pravin
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Glacial Lake Outburst Floods (GLOFs) are a recurring hazard in the Himalayas, posing significant threat to downstream communities. The North Sikkim district of India, comprising the upper reaches of the Teesta River in the Eastern Himalayas, has experienced past GLOF events. The identification of lakes susceptible to this phenomenon is therefore paramount. Using multi-temporal satellite images, this study tracks lake growth in the region, revealing that 203 new lakes had developed herein during the observation period (2000–2018). Of these, 82 lakes had formed during 2011–2018 alone; indicating marked glacial retreat and consequent lake area growth, alongside a rising temperature trend. Using various weighted geometric and geomorphic parameters, the 36 most hazardous lakes were identified, from which the 10 lakes posing the greatest GLOF threat were discerned. These lakes are mostly situated along the main snowline and Great Himalayan water-divide in the north-eastern part of Sikkim and should be monitored continuously.
Phenomenology of photon and di-lepton production in relativistic nuclear collisions
Creators: name: Bratkovskaya, E. L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We discuss the latest theoretical results on direct photon and dilepton production from relativistic heavy-ion collisions. While the dilepton spectra at low invariant mass show in-medium effects like a collisional broadening of the vector meson spectral functions, the dilepton yield at high invariant masses (above 1.1 GeV) is dominated by QGP contributions for central heavy-ion collisions at relativistic energies. The present status of the photon $v_2$ "puzzle" - a large elliptic flow $v_2$ of the direct photons experimentally observed at RHIC and LHC energies - is also addressed. The role of hadronic and partonic sources for the photon spectra and $v_2$ is considered as well as the possibility to subtract the QGP signal from the experimental observables.
description: 8 pages, 4 figures, Proceedings of the XXIV Quark Matter conference, May 19-24 2014, Darmstadt (Germany)
Stable fermion mass matrices and the charged lepton contribution to neutrino mixing
Creators: name: Marzocca, David
name: Romanino, Andrea
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the general properties of hierarchical fermion mass matrices in which the small eigenvalues are stable with respect to perturbations of the matrix entries and we consider specific applications to the charged lepton contribution to neutrino mixing. In particular, we show that the latter can account for the whole lepton mixing. In this case a value of $\sin θ_{13} \gtrsim m_e/m_μ\sinθ_{23} \approx 0.03$, as observed, can be obtained without the need of any fine-tuning, and present data allow to determine the last row of the charged lepton mass matrix with good accuracy. We also consider the case in which the neutrino sector only provides a maximal 12 rotation and show that i) present data provide a $2σ$ evidence for a non-vanishing $31$ entry of the charged lepton mass matrix and ii) a plausible texture for the latter can account at the same time for the atmospheric mixing angle, the $θ_{13}$ angle, and the deviation of the $θ_{12}$ angle from $π/2$ without fine-tuning or tension with data. Finally, we show that the so-called "inverted order" of the 12 and 23 rotations in the charged lepton sector can be obtained without fine-tuning, up to corrections of order $m_e/m_μ$.
description: 27 pages, 1 figure
The impact of market participants’ behaviour on stock, derivatives and energy markets
Creators: name: Zhang, Qin
Publisher: name: Macquarie University
Year: 2023
Subjects: Other education not elsewhere classified

description: This thesis examines the market behaviour of participants in stock, derivative and energy markets to analyse their reactions around exogenous events and factors that the extant literature considers material. The analysis focuses on three key markets and contributes to the literature in each relevant area by extending knowledge on the impact of corporation reputation risks on stock performance, the influence of international energy prices on investors in various industries and the effect of policy uncertainty on pricing behaviour in electricity wholesale markets. The first of three papers in the thesis fills a gap in the knowledge of corporate social responsibility and corporate financial performance by examining how investors (an essential stakeholder class) react to increases in corporate reputation risks in US-listed companies from undesirable environmental, social and corporate governance activities that are illuminated in media reporting. Results from this study using 331,517 US observations indicate that reputation risks have a significant impact on the stock performance of affected firms and the magnitude of investor reactions is dependent on firm characteristics such as size, liquidity and industry classification. The second paper examines the impact of major international energy prices on industries in China, one of the largest global importers and consumers of energy commodities. Using firm-level data of 3750 stock listings across both the Shanghai and Shenzhen stock exchanges, segregated into 138 subindustries under the Global Industry Classification Standard, this study provides a comprehensive analysis of aggregated industry behaviour in relation to the price movements of Brent and WTI crude oil futures, Henry Hub natural gas and Newcastle thermal coal. The research provides empirical evidence that crude oil futures have the most influence on Chinese industries and further analysis suggests that China’s key oil pricing reform on 27 March 2013 has more closely aligned market behaviour to international oil benchmarks. The third paper analyses the impact of energy policy on electricity generation and pricing behaviour in Australia. This research focuses on the impact of introducing a carbon-pricing mechanism (i.e. a ‘carbon tax’) on wholesale electricity markets and how energy policy uncertainty affects generation behaviour. Empirical evidence suggests the carbon tax significantly increased wholesale electricity costs during the two-year regime, after controlling for relevant variables such as local region demand, supply, price volatility, monopolistic characteristics, supply and interregional factors. In addition, there are indications that policy uncertainty may have reduced generation capacity and increased wholesale electricity prices.
Il riconoscimento nell’ordinamento di destinazione degli status familiari costituiti all’estero per motivi di ricongiungimento
Creators: name: Pizzolante, Giuseppina
Publisher: name: Universita' degli Studi di Salerno
Year: 2020
Subjects: SM Case
Civil partnership
Cohabitation
Notion of “direct descendant”
Continuity of personal status

description: This Article considers the definitions of spouse, civil partner and partner in the Citizens’ Rights Directive, in the Family Reunification Directive and in the Italian Law in order to question the traditional approach to defining “family”. Through these Directives, the European Union exercises significant authority over family-based immigration, expressly providing immigration rights to the “spouses” of EU citizens and legal residents. It further highlights the problems created by basing free movement rights of civil partners on host state recognition of such partnerships. This paper provides a critical analysis of the SM Case, where the Court of Justice clarified the meaning of the term “direct descendant” in Directive 2004/38/EC as the starting point for a reflection on the evolving treatment of the family in EU law.
Extended life span of human endometrial stromal cells transfected with cloned origin-defective, temperature-sensitive simian virus 40.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: Human endometrial stromal cells transfected with an origin-defective, temperature-sensitive simian virus 40 recombinant plasmid are dependent on T-antigen function for proliferation and at the permissive temperature have an extended life span in culture. Southern blot analysis indicates that the transfected gene is present in low copy number, possibly at a single integration site. Normal stromal cells are capable of 10 to 20 population doublings in culture. Transfected cultures have been carried at the permissive temperature to 80 population doublings before crisis. In the multistep model of malignant transformation of human cells, these cells represent one of the earliest stages: extended but finite life span. We have used these cells to investigate alterations in signal transduction that may be responsible for this early stage of transformation caused by the large T antigen. Temperature shift experiments indicate that the expression of ornithine decarboxylase (ODC) but not of c-fos is altered by the large T antigen. Induction of c-fos by serum or 12-O-tetradecanoylphorbol-13-acetate is independent of temperature. However, in the transfected cells, the induction of ODC by asparagine or serum is greatly enhanced at the permissive temperature. This result indicates that the large T antigen acts downstream of c-fos but upstream of ODC expression in the signal-transducing cascade.
Genetic analysis of the Rous sarcoma virus subgroup D env gene: mammal tropism correlates with temperature sensitivity of gp85.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: Subgroup D avian sarcoma and leukosis viruses can penetrate a variety of mammalian cells in addition to cells from their natural host, chickens. Sequences derived from the gp85-coding domain within the env gene of a mammal-tropic subgroup D virus (Schmidt-Ruppin D strain of Rous sarcoma virus [SR-D RSV]) and a non-mammal-tropic subgroup B virus (Rous-associated virus type 2) were recombined to map genetic determinants that allow penetration of mammalian cells. The following conclusions were based on host range analysis of the recombinant viruses. (i) The determinants of gp85 that result in the mammal tropism phenotype of SR-D RSV are encoded within the 160 codons that lie 3' of codon 121 from the corresponding amino terminus of the gp85 protein. (ii) Small linear domains of the SR-D RSV gp85-coding domain placed in the subgroup B background did not yield viruses with titers equal to that of the subgroup D virus in a human cell line. (iii) Recombinant viruses that contained subgroup D sequences within the hr1 variable domain of gp85 showed modest-to-significant increases in infectivity on human cells relative to chicken cells. A recombinant virus that contained three fortuitous amino acid substitutions in the gp85-coding domain was found to penetrate the human cell line and give a titer similar to that of the subgroup D virus. In addition, we found that the subgroup D virus, the mutant virus, and recombinant viruses with an increased mammal tropism phenotyp
Acrossocheilus wenchowensis whole genome assembly, annotations and related files of the whole genome.
Creators: name: Luo, Liming
Publisher: name: figshare
Year: 2022
Subjects: subject: 70401 Aquaculture
subject: FOS: Agriculture, forestry and fisheries

description: Chromosome-level genome assembly of Acrossocheilus wenchowensis, with related files
Effects of impurity on tunnel magnetoresistance in a ferromagnetic electrode/carbon nanotube/ferromagnetic electrode junctio
Creators: name: Fouladi, A. Ahmadi
name: Vahedi, J.
name: Soleymani, M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Effects of impurity on the spin-dependent transport in a single wall carbon nanotube spin-valve, as ferromagnetic electrode/carbon nanotube/ferromagnetic electrode model junction is numerically investigated. Using a generalized Green's function method and the Landauer-Buttiker formalism, the impurity conditions are determined by randomly substitution of carbon atoms in the honeycomb carbon nanotube lattice by nitrogen and boron atoms. We have found that transport characteristics, including the spin-dependent current and tunnel magnetoresistance are strongly influenced by the impurity effects. We think that the results of the present report could be useful for designing the future spintronic devices.
description: 6 pages, f figures
On the meson mass spectrum in the covariant confined quark model
Creators: name: Ganbold, Gurjav
name: Gutsche, Thomas
name: Ivanov, Mikhail A.
name: Lyubovitskij, Valery E.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We provide a new insight into the problem of generating the hadron mass spectrum in the framework of the covariant confined quark model. One of the underlying principles of this model is the compositeness condition which means that the wave function renormalization constant of the elementary hadron is equal to zero. In particular, this equation allows to express the Yukawa coupling of the meson fields to the constituent quarks as a function of other model parameters. In addition to the compositeness condition we also employ a further equation which relates the meson mass function to the Fermi coupling. Both equations guarantee that the Yukawa-type theory is equivalent to the Fermi-type theory thereby providing an interpretation of the meson field as the bound state of its constituent fermions (quarks). We evaluate the Fermi-coupling as a function of meson (pseudoscalar and vector) masses and vary the values of the masses in such a way to obtain a smooth behavior for the resulting curve. The mass spectrum obtained in this manner is found to be in good agreement with the experimental data. We also compare the behavior of our Fermi-coupling with the strong QCD coupling alpha_s calculated in an QCD-inspired approach.
description: 12 pages
Identification and functional characterization of Epstein-Barr virus DNA polymerase by in vitro transcription-translation of a cloned gene.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: In order to identify the gene encoding the Epstein-Barr virus (EBV) DNA polymerase, a portion of the BamHI-A fragment containing the fifth leftward open reading frame (BALF5) of the EBV genome was cloned into SP6 and T7 promoter-containing vectors for in vitro transcription-translation. The RNA synthesized in vitro was used to program rabbit reticulocyte lysates, which were analyzed for the synthesis of the putative polymerase polypeptide (110 kDa) and assayed directly for EBV DNA polymerase activity. The polypeptide synthesized by the full-length BALF5 genomic fragment had a molecular mass of 110 kDa. 5'-truncated BALF5 with the first and second ATGs deleted produced 95- and 83-kDa polypeptides, respectively. All three translation products were enzymatically active and displayed resistance to high salt concentrations. The identity of the largest polypeptide as the viral polymerase was established by (i) immunoprecipitation with EBV-positive sera from patients with nasopharyngeal carcinoma and by a rabbit polyclonal antiserum prepared with a synthetic peptide derived from the DNA sequence of BALF5; (ii) identification of a polypeptide of identical size (110 kDa) immunoprecipitated from superinfected Raji cell extracts by these antibodies; and (iii) salt-resistant enzymatic activity which was neutralized by the rabbit EBV antiserum. Thus, BALF5 encodes a functional polymerase identical to that induced in superinfected Raji cells.
The analysis of lithium in HD166473
Creators: name: Shavrina, A. V.
name: Khalack, V.
name: Glagolevskij, Y.
name: Lyashko, D.
name: Landstreet, J.
name: Leone, F.
name: Giarrusso, M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences
subject: J.2

description: The analysis of Li I 6708A line was performed for 6 rotational phases distributed over the whole rotational period (9.5 years) of HD166473. The magnetic field model was constructed based on the polarimetric measurements from (Mathys et al. 20007). For each observed phase the modulus of the magnetic field was also estimated from simulation of the Fe II 6147A, 6149A and Pr III 6706.7A line profiles taking into account Zeeman magnetic splitting. The lithium abundance in each phase was obtained from fitting the observed Li I 6708A profile with the synthetic one calculated assuming Paschen-Back splitting and estimated magnetic field characteristics from Pr III 6706.7A line profile.
description: 2 pages 1 figure, IAU 302 "Magnetic fields throughout stellar evolution"
title: Il riconoscimento delle competenze degli immigrati adulti subsahariani
Creators: name: Angeloni, Brigida
Publisher: name: RomaTrE-Press
Year: 2022

description:

Il volume “Il riconoscimento delle competenze degli immigrati adulti subsahariani” presenta una ricerca empirica nell’area dell’educazione degli adulti ed è stata svolta con la finalità di individuare teorie, metodi, prassi e strumenti che possano efficacemente rispondere all’esigenza degli immigrati adulti subsahariani di ottenere il riconoscimento e la valorizzazione di quanto appreso nei percorsi di studio, ma soprattutto delle competenze acquisite in contesti non formali e informali nei paesi di origine e di transito, al fine di una effettiva inclusione educativa. Il metodo di ricerca adottato è di tipo qualitativo e partecipativo, col fine di analizzare in profondità la complessa questione dell’apprendimento esperienziale degli adulti immigrati e il tema della valorizzazione delle competenze così acquisite, con l’obiettivo di favorire una effettiva inclusione educativa di tipo personalizzato.
Constructing a Preservation Technical Registry by Leveraging Community Best Practices
Creators: name: Wang, Lu
Publisher: name: Zenodo
Year: 2024

description: Developing a machine-readable and continuously updated registry of preservation policies and actions is critical for a digital preservation repository accommodating diverse resource types and designated user communities. To enhance the automated preservation workflow within the National Digital Preservation Program (NDDP), we conducted a comparative analysis of current technical registries in the digital preservation (DP) community. Our assessment focused on the breadth of format coverage, the completeness of risk factors, the frequency of information updates, and the interoperability.

This presentation primarily focuses on three key aspects:

1.    Designing the data model: We customized the Schema and API of the Preservation Action Registry (PAR) to cater to our internal workflow logic.

2.    Aggregating format risk factors: We sourced risk factors from reputable repositories such as the TNA's PRONOM,  and NARA's preservation framework etc., Subsequently, we designed NDPP’s format risk quantification formula based on its 37 factors. 

3.    Implementing dynamic updates: Our system is capable of dynamically detecting updates from community information sources and triggering preservation activities for relevant archived resources in time.
Design, synthesis, and biological evaluation of novel ciprofloxacin derivatives as potential anticancer agents targeting topoisomerase II enzyme
Creators: name: Swedan, Hadeer K.
name: Kassab, Asmaa E.
name: Gedawy, Ehab M.
name: Elmeligie, Salwa E.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: A series of novel ciprofloxacin (CP) derivatives substituted at the N-4 position with biologically active moieties were designed and synthesised. 14 compounds were 1.02- to 8.66-fold more potent than doxorubicin against T-24 cancer cells. Ten compounds were 1.2- to 7.1-fold more potent than doxorubicin against PC-3 cancer cells. The most potent compounds 6, 7a, 7b, 8a, 9a, and 10c showed significant Topo II inhibitory activity (83–90% at 100 μM concentration). Compounds 6, 8a, and 10c were 1.01- to 2.32-fold more potent than doxorubicin. Compounds 6 and 8a induced apoptosis in T-24 (16.8- and 20.1-fold, respectively compared to control). This evidence was supported by an increase in the level of apoptotic caspase-3 (5.23- and 7.6-fold, sequentially). Both compounds arrested the cell cycle in the S phase in T-24 cancer cells while in PC-3 cancer cells the two compounds arrested the cell cycle in the G1 phase. Molecular docking simulations of compounds 6 and 8a into the Topo II active site rationalised their remarkable Topo II inhibitory activity.
Mutational analysis of a virulence locus in the E2 glycoprotein gene of Sindbis virus.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: The substitution of arginine for serine at position 114 of glycoprotein E2 in several biological and recombinant Sindbis virus mutants was shown previously to attenuate the virus for neonatal mice and also to accelerate virus penetration into BHK cells. To further examine the genetically linked effects on both virus penetration into cultured cells and pathogenesis in vivo, mutants containing each of 16 different amino acid coding changes at this position were generated by site-directed mutagenesis of a full-length cDNA clone of the Sindbis virus genome. Viable virus was recovered following transfection of RNA transcripts from 14 of the clones. Phenotypic analysis of these virus mutants revealed that specific amino acid residues affected either the pathogenesis or penetration phenotype independently or both phenotypes simultaneously. Thus, both the position of a mutation within the E2 sequence and the particular amino acid encoded at that position are important determinants of the mutant phenotypes.
The association between dietary inflammatory index and psychological profile among men with spinal cord injury
Creators: name: Mohammadi, Hamed
name: Parastouei, Karim
name: Rostami, Hosein
name: Fadel, Abdulmnannan
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Medicine
subject: Neuroscience
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: The present study was designed to examine the relationship between the dietary inflammatory index (DII) and depression, anxiety and stress in Iranian men with spinal cord injury (SCI). Cross-sectional study. Mottahary SCI clinic, Isfahan, Iran. The current study was conducted on 150 men with SCI aged 40–65 years. Dietary data were collected using a semi-quantitative 148 item food frequency questionnaire (FFQ). The Depression, Anxiety, Stress Scale-21 (DASS-21) was used to assess the psychological profile of the participants. The DII score ranged from −3.62 to 4.02. Overall, 34% of study participants had at least mild levels of depression and anxiety symptoms and 25% had at least mild levels of stress symptoms. A one-unit increase in the DII was significantly associated with higher scores of depressive symptoms (β = 1.31, 95% CI 0.44–2.18; P = 0.003). Also, a one-unit increase in the DII was associated with higher odds of having at least mild depressive symptoms (OR = 1.77, 95% CI 1.17, 2.67; P = 0.007). No significant association was found between the DII and anxiety and stress. The present study indicated that a higher DII score is associated with higher odds of depressive symptoms in men with SCI. These initial findings highlight the crucial role of the inflammatory potential of diet in the mental health of subjects with SCI. Future prospective studies are warranted to confirm these findings.
Actin automata: Phenomenology and localizations
Creators: name: Adamatzky, Andrew
name: Mayne, Richard
Publisher: name: arXiv
Year: 2014
Subjects: subject: Emerging Technologies (cs.ET)
subject: Cellular Automata and Lattice Gases (nlin.CG)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: Actin is a globular protein which forms long filaments in the eukaryotic cytoskeleton, whose roles in cell function include structural support, contractile activity to intracellular signalling. We model actin filaments as two chains of one-dimensional binary-state semi-totalistic automaton arrays to describe hypothetical signalling events therein. Each node of the actin automaton takes state `0' (resting) or `1' (excited) and updates its state in discrete time depending on its neighbour's states. We analyse the complete rule space of actin automata using integral characteristics of space-time configurations generated by these rules and compute state transition rules that support travelling and mobile localizations. Approaches towards selection of the localisation supporting rules using the global characteristics are outlined. We find that some properties of actin automata rules may be predicted using Shannon entropy, activity and incoherence of excitation between the polymer chains. We also show that it is possible to infer whether a given rule supports travelling or stationary localizations by looking at ratios of excited neighbours are essential for generations of the localizations. We conclude by applying biomolecular hypotheses to this model and discuss the significance of our findings in context with cell signalling and emergent behaviour in cellular computation.
Proteolytic processing of the Sindbis virus membrane protein precursor PE2 is nonessential for growth in vertebrate cells but is required for efficient growth in invertebrate cells.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: We have shown previously that processing of the Sindbis virus envelope protein precursor PE2 to envelope protein E2 is not required for virus maturation in cultured vertebrate fibroblast cells and that unprocessed PE2 can be incorporated into infectious virus in place of E2 (J. F. Presley and D. T. Brown, J. Virol. 63:1975-1980, 1989; D. L. Russell, J. M. Dalrymple, and R. E. Johnston, J. Virol. 63:1619-1629, 1989). To better understand the role of this processing event in the invertebrate vector portion of the alphavirus life cycle, we have examined the maturation of Sindbis virus mutants defective in PE2 processing in cultured mosquito cells. We found that although substantial amounts of structural proteins PE2, E1, and C were produced in infected mosquito (aedine) cell lines, very little infectious virus was released. When the period of infection was extended, plaque size variants appeared, some of which exhibited a restored ability to grow in mosquito cells. The nucleotide sequences of two such variants were determined. These variants contained point mutations that restored PE2 cleavage, indicating a genetic linkage between failure to cleave PE2 and failure to grow in mosquito cells
The 5' nontranslated region of hepatitis A virus RNA: secondary structure and elements required for translation in vitro.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1991

description: Although the lengthy 5' nontranslated regions (5'NTRs) of other picornaviral RNAs form highly ordered structures with important functions in viral translation, little is known about the 5'NTR of hepatitis A virus (HAV). We determined the nearly complete 5'NTR nucleotide sequences of two genetically divergent HAV strains (PA21 and CF53) and included these data in a comparative phylogenetic analysis of the HAV 5'NTR. We identified covariant nucleotide substitutions predictive of conserved secondary structures and used this information to develop a model of the 5'NTR secondary structure, which was further refined by thermodynamic predictions and nuclease digestion experiments. According to this model, the 5'NTR comprises six major structural domains. Domains I and II (bases 1 to 95) contain a 5'-terminal hairpin and two stem-loops followed by a single-stranded and highly variable pyrimidine-rich tract (bases 96 to 154). The remainder of the 5'NTR (domains III to VI, bases 155 to 734) contains several complex stem-loops, one of which may form a pseudoknot, and terminates in a highly conserved region containing an oligopyrimidine tract preceding the putative start codon by 13 bases. To determine which structural elements might function as an internal ribosome entry site, RNA transcripts representing the HAV 5'NTR with progressive 5' deletions were translated in rabbit reticulocyte lysates. The translation product was truncated, unprocessed P1 polyprotein. Removal of the 5'-terminal 354 bases of the 5'NTR had little effect on translation. However, deletion to base 447 slightly decreased translation, while deletion to base 533 almost completely abolished it. These data indicate that sequences 3' of base 355 play an important role in the translation mechanism utilized by genomic-length HAV RNA. Significantly, this region shares several conserved structural features with the internal ribosome entry site element of murine encephalomyocarditis virus.