title: ÐÑÐ¾ÐµÐºÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ Ð»Ð¸Ð½Ð¸Ð¸ Ð´Ð»Ñ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²Ð° ÑÑÐ±ÑÑÐ°Ð½ÑÐ¸Ð¸-Ð¿Ð¾ÑÐ¾ÑÐºÐ° ÐÐ´ÐµÐ¼ÐµÑÐ¸Ð¾Ð½Ð¸Ð½Ð° 1,4-Ð±ÑÑÐ°Ð½Ð´Ð¸ÑÑÐ»ÑÑÐ¾Ð½Ð°ÑÐ°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Designing a line for the production of Ademetionine 1,4-butanedisulfonate sub-stance-powder
Creators: name: ÐÐ¸Ð¼Ð°ÑÐ¸Ð½, ÐÐ½ÑÐ¾Ð½
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: ÐÐ¸Ð¾ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸Ñ
Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ²Ð¾ Ð°Ð´ÐµÐ¼ÐµÑÐ¸Ð¾Ð½Ð¸Ð½Ð° 1
4-Ð±ÑÑÐ°Ð½Ð´Ð¸ÑÑÐ»ÑÑÐ¾Ð½Ð°Ñ
Ð°Ð´ÐµÐ¼ÐµÑÐ¸Ð¾Ð½Ð¸Ð½ 1
4-Ð±ÑÑÐ°Ð½Ð´Ð¸ÑÑÐ»ÑÑÐ¾Ð½Ð°Ñ ÑÑÐ±ÑÑÐ°Ð½ÑÐ¸Ñ-Ð¿Ð¾ÑÐ¾ÑÐ¾Ðº
Ð²Ð°Ð»Ð¸Ð´Ð°ÑÐ¸Ñ ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¿ÑÐ¾ÑÐµÑÑÐ°
production of ademethionine 1
4-butanedisulfonate
ademetheionine 1
4-butanedisulfonate substance-powder
validation of the technological process

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description: Topic of the research work: âDesigning a line for the production of Ademetionine 1,4-butanedisulfonate substance-powderâ.In the introduction, the relevance of the topic is substantiated, the purpose of the work is established, the tasks, scientific novelty, practical significance and testing of the research results are listed. The literature review provides information on the problem of hepatobiliary pathologies, the effect of ademetionine concentration in the body on liver and central nervous system diseases, as well as ways to prevent and treat them. The physicochemical properties of ademethionine 1,4-butanedisulfonate are given. The conducted literature review confirmed the urgency of creating in Russia the production of ademetionine 1,4-butane disulfonate, a substance-powder.In the experimental part, a technology was developed for the production of ademetionine 1,4-butanedisulfonate, a substance-powder, taking into account modern requirements for medicines. A pilot industrial regulation for the production of ademetionine 1,4-butanedisulfonate, powder substance (ÐÐÐ -59468661-006-2021) has been developed. The production process was validated without changes and deviations in compliance with all critical parameters. It has been confirmed that the process is reproducible, repeatable and guarantees a stable output of products in all quality indicators that meet the requirements of the draft pharmacopoeial monograph. A feasibility study for the production of ademetionine 1,4-butanedisulfonate, a substance-powder, has been carried out. The technology for the production of ademetionine 1,4-butanedisulfonate, substance-powder has been tested and implemented at Farmamed LLC.