cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Potential impact of packaging type material in beer quality
Creators: name: Santos, Diana
name: Pereira, Maria João
name: Oliveira, Ana Isabel
name: Pinho, Cláudia
Publisher: name: Scientific Letters
Year: 2024

description: Background: The materials in which beverages are packed are crucial to maintain quality, nutritional properties, and safety of the final product. In what beer concerns, and even under optimal storage conditions, its quality deteriorates as the product approaches the expiration date, regardless of the container type in which it is packed [1]. Therefore, a careful selection of packaging is imperative to maintain beer´s integrity and quality, when tasted by the consumer. Objective: This work aims to discuss how the type of beer packaging influences the integrity and quality of this beverage during storage. Methods: A literature review was performed, using PubMed, b-on, and Web of Science databases. Articles related to the influence of packaging types on beer quality, in English, and published in the last 5 years were included. Results: Plastic bottles (PB) proved to be the least suitable type of packaging for long-term storage, as beer exhibits significant changes in volatile compounds, turbidity, color, bitterness intensity, and decrease in CO2 content, unlike glass bottles (GB), aluminum cans (AC), and stainless steel kegs (KG), where these parameters remain constant [1-3]. Furthermore, Brown GB proved to be a more effective barrier against light compared to green GB and PB, as well as containing lower amounts of phthalates than beers in PB and AC [4,5]. AC was capable of retaining all organoleptic characteristics, showing a slight increase in bitterness after 10 months of storage [1]. However, beers stored in AC were characterized by higher aluminum contents compared to the products stored in glass bottles [6]. Conclusions: The beer packaging material plays a crucial role in its quality. Thus, GB, AC and KG, due to their barrier characteristics and protection against external factors, generally outperform PB in preserving the integrity and quality of beer.
description: Scientific Letters, Vol. 1 No. Sup 1 (2024)
ALSUntangled #66: antimycobacterial antibiotics.
Creators: name: Pierce, Ellen S.
name: Barkhaus, Paul
name: Beauchamp, Morgan
name: Bromberg, Mark
name: Carter, Gregory T.
name: Goslinga, Jill
name: Greeley, David
name: Kihuwa-Mani, Sky
name: Levitsky, Gleb
name: Lund, Isaac
name: McDermott, Christopher
name: Pattee, Gary
name: Pierce, Kaitlyn
name: Polak, Meraida
name: Ratner, Dylan
name: Wicks, Paul
name: Bedlack, Richard
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Several infections have been associated with motor neuron diseases resembling ALS, including species of viruses, bacteria, and parasites. Mycobacterium avium subspecies paratuberculosis (MAP), most known for its probable etiologic association with Crohn’s disease, has been suggested as another possible infectious cause of motor neuron disease. Two published case reports describe the successful treatment of ALS-like symptoms with antimycobacterial antibiotics. Both cases had atypical features. Based on these, we believe it would be reasonable to begin performing chest imaging in PALS who have features of their history or exam that are atypical for ALS such as pain, fevers, or eye movement abnormalities. If the chest imaging is abnormal, more specific testing for mycobacteria may be indicated. Until there is more clear evidence of an association between mycobacteria and ALS, we cannot endorse the widespread use of potentially toxic antimycobacterial antibiotics for PALS.
title: Sustainable Recruitment: The Bottom Line
Creators: name: Bravington, Mark V.
name: O'Brien, Carl M.
name: Stokes, T. Kevin
Publisher: name: ASC 1999 - P - Theme session
Year: 2024
Subjects: Pressures, impacts, conservation, and management

description: No abstracts are to be cited without prior reference to the author.This paper develops a single-species perspective on the limits of sustainable fishing. Given uncertain data and assessments, the problem is to determine lower confidence limits for the minimum fishing mortality rate F-. which, if maintained indefinitely, would drive the stock to extinction. For non-depensatory stocks, F-. is determined by the slope of the stock-recruitment curve at the origin. The paper reviews three different approaches to making inferences about F-.: recruit-per-biomass relationships (e.g. Fhigh), parametric curves (e.g. Ricker), and constrained nonparametric curves (e.g. Cook's Fioss)- Of these, constrained nonparametic curves are potentially the best, but at present suffer from practical difficulties in implementation and do not always give biologically sensible fits. These difficulties can be circumvented using two new nonparametric methods, CONCR (Concave Recruitment) and DIMPOS (Diminishing returns, Positive recruitment), which are described and applied to several ICES stocks. Finally, the paper explores issues surrounding the use of sustainable recruitment measures in assessment and management.
THE VILLAGE LIBRARY OF ROLE CHANGING CITIZENS' BEHAVIOR
Creators: name: Gutriyana
name: Hasbi
name: Rahmat Muhammad
name: Sitti Nurani Siradjuddi
Publisher: name: Zenodo
Year: 2024
Subjects: Library, Village, Social Change, Livestock Breeders.

description: Abstract

Libraries play a role as institutions that provide sources of knowledge for the community which are expected to inspire readers to carry out social change. This research aims to analyze changes in residents' behavior through village library activities. This research was conducted in Pajukukang Village, Maros Regency using qualitative methods. Data was collected by interviews and field observations. Data were analyzed using an interpretive qualitative approach. The Pajukukang Village Government manages the Al-Iqra village library which later received an award as a Transformative Village. This research indicates the village library of role changing citizens’ behavior by becoming active livestock breeder.  Active residents read in the library and gain knowledge about raising ducks. Village libraries make residents have the capacity to change their socio-economic behavior to be more productive.
Primary lateral sclerosis natural history study – planning, designing, and early enrollment
Creators: name: Mitsumoto, Hiroshi
name: Jang, Grace
name: Lee, Ikjae
name: Simmons, Zachary
name: Sherman, Alexander V.
name: Heitzman, Daragh
name: Sorenson, Eric
name: Cheung, Ken
name: Andrews, Jinsy
name: Harms, Matthew
name: Shneider, Neil A.
name: Santella, Regina
name: Paganoni, Sabrina
name: Ajroud-Driss, Senda
name: Fernandes, J. Americo M.
name: Burke, Katherine M.
name: Gwathmey, Kelly
name: Habib, Ali A.
name: Maragakis, Nicholas J.
name: Walk, David
name: Fournier, Christina
name: Heiman-Patterson, Terry
name: Wymer, James
name: Diaz, Frank
name: Scelsa, Stephen N.
name: Elman, Lauren
name: Genge, Angela
name: Goutman, Stephen A.
name: Hayat, Ghazala
name: Jawdat, Omar
name: Johnston, Wendy S.
name: Joyce, Nanette C.
name: Kasarskis, Edward J.
name: Kisanuki, Yaz Y.
name: Lomen-Hoerth, Catherine
name: Pulley, Michael T.
name: Shah, Jaimin S.
name: Shoesmith, Christen
name: Zinman, Lorne
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Introduction/Aims. Primary lateral sclerosis (PLS) is exceedingly rare and has been an enigmatic disease. Recent progress has drastically changed this perception, with early biomarkers being investigated and potential medications for PLS emerging at the preclinical stage. The aim of this paper is to describe a study of PLS natural history and discuss the limitations and proposed solutions to the study of a rare and slowly progressive disease. Methods. The PLS Natural History Study is a 30-site, 24-month, prospective study that is supported by multiple funding sources. The study aims to enroll 50 early PLS (disease duration ≤4 years) and 50 definite PLS (disease duration 4 to 15 years) participants using modified PLS Diagnostic Criteria. Smartphone-based assessments including semi-quantitative and quantitative measures and patient-reported outcomes are utilized. In-person quantitative measures are also completed during site visits. The change in the PLS Functional Rating Scale score is the primary outcome. The study utilizes the NeuroBANK® patient-centric data capture and management platform. The biostatistical analysis plan has been developed. Results. In one year, 28 participants have been recruited. Enrollment has been much slower than anticipated due to the COVID-19 pandemic, the rarity of PLS, and potential study competition for internal resources from ALS clinical trials. Discussion. We discuss the need for more innovative methods to enroll and study individuals with such rare diseases and propose a number of mechanisms by which more efficient enrollment could be facilitated.
Pseudanthias squamipinnis
Creators: name: Bariche, Michel
name: Fricke, Ronald
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Perciformes
Serranidae
Pseudanthias
Pseudanthias squamipinnis

description: Pseudanthias squamipinnis (Peters 1855) —Sea goldie
Taxonomy. Single record from Lebanon as Pseudanthias squamipinnis (Peters 1855) by Bitar (2013: 592). This record is based on two pictures taken underwater in Beirut (June 2000). The species has never been observed or collected in the Mediterranean afterwards.
Distribution. Red Sea, Indo-West Pacific: East Africa, South Africa, Persian Gulf, Socotra, Madagascar, Al- dabra and western Mascarenes east to Society Islands, north to southern Japan, south to Western Australia, New Caledonia, Lord Howe Island and Tonga.
Conservation. IUCN: Global (LC: 12 March 2015). Capture and threats: Unknown. Occurrence: Very rare. Non-indigenous species, no conservation action needed.
description: Published as part of Bariche, Michel & Fricke, Ronald, 2020, The marine ichthyofauna of Lebanon: an annotated checklist, history, biogeography, and conservation status, pp. 1-157 in Zootaxa 4775 (1) on pages 138-139, DOI: 10.11646/zootaxa.4775.1.1, http://zenodo.org/record/3983887
Cephalopholis taeniops
Creators: name: Bariche, Michel
name: Fricke, Ronald
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Perciformes
Serranidae
Cephalopholis
Cephalopholis taeniops

description: Cephalopholis taeniops (Valenciennes 1828) —Bluespotted seabass
Taxonomy. First record from Lebanon as Cephalopholis taeniops (Valenciennes 1828) by Crocetta & Bariche in Gerovasileiou et al. (2017: 377–378). Material in collection: AUBM (OS3914).
Distribution. Mediterranean Sea, eastern Atlantic: Morocco south to Angola, including Canary Islands, Cape Verde Islands, and islands in the Gulf of Guinea; introduced in Brazil (southwestern Atlantic).
Conservation. IUCN: Global (LC: 17 November 2016). Capture and threats: Unknown. Occurrence: Very rare. Non-indigenous species, no conservation action needed.
description: Published as part of Bariche, Michel & Fricke, Ronald, 2020, The marine ichthyofauna of Lebanon: an annotated checklist, history, biogeography, and conservation status, pp. 1-157 in Zootaxa 4775 (1) on page 139, DOI: 10.11646/zootaxa.4775.1.1, http://zenodo.org/record/3983887
Antioxidant profile of Portuguese and Spanish craft beers
Creators: name: Pereira, Maria João
name: Santos, Diana
name: Pinho, Cláudia
name: Oliveira, Ana Isabel
Publisher: name: Scientific Letters
Year: 2024

description: Background: The antioxidant potential of craft beer (CB) may be due to high quality of the raw materials (water, malt, hop and yeast) and traditional techniques [1-4]. The scarcity of studies evaluating the antioxidant potential of CB highlights the relevance of this study. Objective: In vitro evaluation of the antioxidant activity of aqueous extracts of Portuguese and Spanish CB. Methods: Experimental study using six CB with different styles: Milk Stout (EL-MS), India Pale Ale (EL-IPA, ALM-IPA), Imperial Stout (EME-IS), Oatmeal Stout (ALM-OS), Pilsner (EL-P), Munich Dunkell (B-MD) and two industrial beers, Pilsner (S-P) and Munish Dunkell (S-MD). The pH, acidity content (AC) and total phenolic compounds (TPC) were determined. The antioxidant capacity was assessed using 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and the hydrogen peroxide (H2O2) assays, expressed in concentration for 50% activity inhibition (IC50). One-way ANOVA and Student’s t-test were used for statistical analysis in GraphPad® Prism 8.0 software, with a significance level of 0.05. Results: The pH of the beers varied between 3.89±0.00-4.78±0.05 and AC between 0.13±0.01-0.44±0.01%. ALM-IPA had the highest TPC value (8.96±0.64mg gallic acid equivalents/g). IPA style presented the lower IC50 values in H2O2 (ALM-IPA with an IC50=23.54±1.53µg/mL, p<0.05) and ABTS (EL-IPA with an IC50=55.21±4.68µg/mL, p<0.05) assays. The industrial beers have lower TPC values compared to CB (same style, p<0.05), and lower capacity to neutralize the H2O2 and ABTS radicals. For Omisore et al. (2005), samples with IC50>50μg/mL are classified as being moderately active, while samples with IC50<50μg/mL have high antioxidant capacity. Also, the results for IPA style are in line with Breda et al. (2022), in which light-colored beers had better antioxidant profiles. However, according to Silva et al. (2022) the best antioxidant profiles were associated with dark beers. Conclusions: The samples showed antioxidant potential, but further tests should be carried out considering the complex underlying antioxidant mechanisms.
description: Scientific Letters, Vol. 1 No. Sup 1 (2024)
Siganus luridus
Creators: name: Bariche, Michel
name: Fricke, Ronald
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Perciformes
Siganidae
Siganus
Siganus luridus

description: Siganus luridus (Rüppell 1829) —Dusky spinefoot
Taxonomy. First record from Lebanon as Siganus luridus Rüppell 1828 by George et al. (1964: 20); subsequently recorded as Siganus luridus (Rüppell) by Mouneimné (1977: 64); as Siganus luridus (Rüppell 1828) by Mouneimné (2002: 201–202); recently recorded as Siganus luridus (Rüppell 1829) by Bariche et al. (2003; 2004; 2005); as Siganus luridus by Carpentieri et al. (2009: 3); as Siganus luridus by Bariche et al. (2015: 2366); as Siganus luridus by Fanelli et al. (2015: 2169); and Aguillar et al. (2018: 82). Material in collection: AUBM, BMNH, SMF and USNM.
Distribution. Red Sea, western Indian Ocean: East Africa to Comores and Madagascar, Réunion and Mauritius (western Mascarenes); Mediterranean Sea (Red Sea immigrant).
Conservation. IUCN: Global (LC: 19 July 2017). Capture and threats: Unknown. Occurrence: Very common. Non-indigenous species, no conservation action needed.
description: Published as part of Bariche, Michel & Fricke, Ronald, 2020, The marine ichthyofauna of Lebanon: an annotated checklist, history, biogeography, and conservation status, pp. 1-157 in Zootaxa 4775 (1) on pages 139-140, DOI: 10.11646/zootaxa.4775.1.1, http://zenodo.org/record/3983887
Frequency of C9orf72 and SOD1 mutations in 302 sporadic ALS patients from three German ALS centers
Creators: name: Yilmaz, Rüstem
name: Grehl, Torsten
name: Eckrich, Lukas
name: Marschalkowski, Ines
name: Weishaupt, Kanchi
name: Valkadinov, Ivan
name: Simic, Melita
name: Brenner, David
name: Andersen, Peter M.
name: Wolf, Joachim
name: Weishaupt, Jochen H.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Background: ALS patients with a negative family history (sporadic ALS, SALS) represent more than 90% of all ALS cases. In light of the gene-specific therapies that are currently in development for ALS, knowledge about the genetic landscape of SALS in Germany is urgently needed. Objectives: We aimed to determine the frequency of C9orf72 hexanucleotide repeat expansion (HRE) and SOD1 mutations among patients in Germany with a diagnosis of sporadic or idiopathic ALS. Methods: We genotyped SALS patients from three German ALS centers. Sanger sequencing, fragment length analysis, and repeat-primed PCR technologies were used to detect mutations in SOD1 and C9orf72 HRE. Pathological C9orf72 HRE results were confirmed in an independent laboratory. Results: In 302 patients with SALS, 27 (8.9%) patients with a C9orf72 HRE mutation were detected. Moreover, we identified two patients with a pathogenic SOD1 mutation, one patient with a heterozygous p.D91A mutation in SOD1, and three additional patients with rare SOD1 variants not predicted to change the amino acid sequence. Conclusions: According to our data, the proportion of SALS patients with SOD1 mutations is in the expected range, whereas that with C9orf72 HRE is higher, suggesting a reduced penetrance. A considerable number of SALS patients can be amenable to gene-specific therapies.
title: Variability In The Slope Water Properties Off Eastern North America And Their Effects On The Adjacent Shelves
Creators: name: Drinkwater, K.F.
name: Mountain, D.B.
name: Herman, A.
Publisher: name: ASC 1999 - O - Theme session
Year: 2024
Subjects: Pressures, impacts, conservation, and management

description: No abstracts are to be cited without prior reference to the author.Long-term variability in the deep basins of the Scotian Shelf and Gulf of Maine in the NW Atlantic has been shown to be dependent upon the offshore slope water properties. The main focus of this paper is document recent events that have helped increase our understanding of the causes of the climate changes in the slope waters and their effects on shelf water. Temperature and salinity measurements reveal the replacement of Wann Slope Waters adjacent to the continental break along the Scotian Shelf and Gulf of Maine by colder, fresher Labrador Slope Water during the autumn of 1997 and winter of 1998. Temperatures dropped by 2-4°C along the slope depending upon location and depth.
Looking at the potential of marine macroalgae supplementation to afford neuroprotection against the effects of inorganic mercury in fish (Diplodus sargus)
Creators: name: Neto, Ana
name: Brandão, Fátima
name: Almeida, Armando
name: Abreu, Helena
name: Pousão-Ferreira, Pedro
name: Cesário, Rute
name: Pacheco, Mário
name: Pereira, Patrícia
Publisher: name: Scientific Letters
Year: 2024

description: Background: Marine macroalgae have potential as a source of many natural compounds with health benefits [1], but their use to mitigate aquatic contaminants bioaccumulation in fish and resultant toxicity is an underexplored research topic. Objective: Asses if a marine macroalgae-enriched diet can provide neuroprotection Diplodus sargus when exposed to waterborne inorganic mercury (iHg), namely by reducing bioaccumulation in the brain and mitigating oxidative stress and behavioral impairments. Methods: Fish were fed for 3 months with a marine macroalgae enriched-diet (Ma) [total incorporation of 5%, with the species Ulva rigida, Fucus vesiculosus and Gracilaria gracilis], while non-supplemented fish were fed with a standard diet (S). Upon that period, both groups were exposed to inorganic Hg (iHg) (2 μg L-1) for 7 days (E7) (constituting groups MaHg and SHg), followed by a post-exposure period of 14 days (PE14). Control fish (MaC and SC), unexposed to iHg, were maintained over the experiment. At those experimental times, Hg levels in the brain were assessed, together with antioxidants and lipid peroxidation. Motor behavior was also evaluated. Results: The brain of MaHg fish had significantly lower levels of Hg than SHg fish, both at E7 and PE14. Interestingly, fish under a macroalgae-enriched diet exhibited a significant decrease of glutathione peroxidase and glutathione reductase activities upon exposure to iHg for 7 days, as well as of total glutathione content. MaHg fish also exhibited a higher velocity in the first run when compared to unexposed fish, as well as a lower time in the first run. Fish fed with macroalgae-diet run faster in the first run than their congeners under a standard diet. Conclusions: Current data underpinned potential neurological advantages of macroalgae supplementation to fish, namely by decreasing Hg bioaccumulation and improving motor behavior. Moreover, a decrease of antioxidants was found in supplemented fish when exposed to Hg.
description: Scientific Letters, Vol. 1 No. Sup 1 (2024)
Siganus rivulatus Forsskal & Niebuhr 1775
Creators: name: Bariche, Michel
name: Fricke, Ronald
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Perciformes
Siganidae
Siganus
Siganus rivulatus

description: Siganus rivulatus Forsskål & Niebuhr 1775 —Marbled spinefoot
Taxonomy. First record from Lebanon as Amphacanthus siganus, Rüpp. by Gruvel (1931: 98); subsequently recorded as Siganus rivulatus (Forskäl 1775) by George et al. (1964: 20); as Siganus rivulatus Forsskål by Mouneimné (1977: 64); as Siganus rivulatus Forsskål 1775 by Mouneimné (2002: 202–203); recently recorded as Siganus rivulatus by Bariche et al. (2003; 2004; 2005); as Siganus rivulatus by Carpentieri et al. (2009: 3); as Siganus rivulatus by Bariche et al. (2015: 2366) and Fanelli et al. (2015: 2169); Material in collection: ANSP, AUBM, BMNH, MCZ, USNM and YPM.
Distribution. Red Sea, western Indian Ocean: East Africa, Socotra; Mediterranean Sea and Sea of Marmara (Red Sea immigrant).
Conservation. IUCN: Global (LC: 4 February 2009). Capture and threats: Unknown. Occurrence: Very common. Non-indigenous species, no conservation action needed.
description: Published as part of Bariche, Michel & Fricke, Ronald, 2020, The marine ichthyofauna of Lebanon: an annotated checklist, history, biogeography, and conservation status, pp. 1-157 in Zootaxa 4775 (1) on page 140, DOI: 10.11646/zootaxa.4775.1.1, http://zenodo.org/record/3983887
Parasitological research of myxozoans in 2 species of benthic fish from Northeast Atlantic waters
Creators: name: Casal, Graça
name: Soares, Rúben
name: Sá, Mónica
name: Alves, Ângela
name: Rocha, Sónia
Publisher: name: Scientific Letters
Year: 2024

description: Background: Myxozoa Grassé, 1970 constitutes a diverse and widespread group of endoparasites that mainly use fish as intermediate hosts and are frequently associated with increased mortality [1]. The increase in the commercialization of sole species in Portugal promotes economic growth in fishing industry and there are presently efforts to produce it in aquaculture. However, despite its commercial relevance, there is a lack of information about parasitic infections in several benthic fish. Objective: This study aimed to investigate the diversity of myxosporeans parasitizing stocks of two sole species of high commercial value, Solea senegalensis and Synaptura cadenati, caught in Northeast Atlantic waters. Methods: The specimens were necropsied and a myxozoan survey was carried out in the internal and external tissues. Samples of tissue were analysed by light microscopy and, when infected, were photographed for morphological characterization, as well as prepared for histology and molecular procedures targeting 18S rDNA. Positive PCR products were sequenced, and the consensus sequences were analysed by BLAST in MEGA11 software. Results: The morphological data revealed the presence of two parasites in the S. cadenati, in the gallbladder Ceratomyxa sp. and in the urinary bladder Ortholineasp. with a prevalence of 16.7% and 25%, respectively. In S. senegalensis, a parasite of the genus Zschokkella was identified in the gallbladder and a Sphaerospora sp., was found in the urinary bladder with the prevalence of 27.3% and 9.1%, respectively. Molecular analysis confirmed the identification of both gallbladder species, while the parasites infecting the urinary bladder are currently being processed. Conclusions: In S. senegalensis, a new occurrence of Zschokkella soleae, a species previously described in Solea solea, was found in the same tissue [2]. In S. cadenati, a new species of Ceratomyxa was identified, whose molecular analysis demonstrated that it is closely related to Ceratomyxa spp. from the same geographic area.
description: Scientific Letters, Vol. 1 No. Sup 1 (2024)
Creating Interpretable Data-Driven Approaches for Remote Health Monitoring
Creators: name: Ghods, Alireza
Publisher: name: Washington State University
Year: 2023
Subjects: Data Visualization
Deep Learning
Health Informatic
Interpretable Machine Learning
Machine Learning
Time Series Analysis

description: The impending "age wave'' underscores the urgent need for technology that supports remote health monitoring. This research focuses on developing technologies to improve clinician interpretability of remote health monitoring systems. These technologies visualize and summarize raw data and machine learning inferences. Unlike prior methods, this dissertation describes techniques developed in partnership with the target end user: clinicians. Keeping the clinician in the design loop improves technology trust, adoption, and patient outcomes.
description: In this research, we introduce two visualization studies that illustrate and validate the human-in-the-loop approach, demonstrating that with this technique clinicians can successfully identify health events from unconventional data sources, such as smart homes and smartwatches. To complement these studies, the research also introduce methods to create machine learning models that are interpretable for humans. Here, we focus on discovering and communicating patterns that summarize complex data and justify machine learning decisions. All of the introduced algorithms yield improved objective performance on synthetic and real-world complex data. To evaluate their efficacy for remote health monitoring, the methods are assessed by clinician end users in a series of comparative surveys. In these experiments, the methods introduced in this dissertation show significantly enhanced interpretability. We discuss the implications and limitations of this work for remote health monitoring systems and offer ideas for continued work.
Metabolic profiling of renal cell carcinoma tissue using gas chromatography metabolomics
Creators: name: Amaro, Filipa
name: Carvalho, Márcia
name: Carvalho-Maia, Carina
name: Jerónimo, Carmen
name: Henrique, Rui
name: Bastos, Maria De Lourdes
name: Guedes De Pinho, Paula
name: Pinto, Joana
Publisher: name: Scientific Letters
Year: 2024

description: Background: Renal cell carcinoma (RCC) is marked by dysregulation of angiogenesis, energy metabolism, and nutrient sensing pathways [1]. This diversity is an obstacle to achieving long-term responses to treatment, notwithstanding progress in targeted and immunotherapeutic drugs. Objective: This study aimed to characterise the metabolic dysregulations that occur in RCC tissue using a metabolomics approach. Methods: Tumour and non-tumour kidney tissues were collected from 18 patients who underwent nephrectomy at the Portuguese Oncology Institute of Porto (IPO-Porto). Ethical approval (238/2018) and written consent were obtained. Tissues were homogenised, and metabolites were extracted using a methanol-water technique. Metabolites were then analysed by gas chromatography-mass spectrometry (GC-MS) analysis. Statistical methods and pathway analysis were used to interpret potential dysregulations associated with RCC. Results: RCC tissue showed a significant reduction in amino acid levels (including alanine, asparagine, aspartate, serine, tyrosine, among others), except for β-alanine and glutamate, which exhibited significant elevated levels. Perturbations in organic acids were observed, with a significant decrease in fumarate and gluconate levels and an increase in 3-aminobutyrate, citrate, and lactate. Increased levels of glucose and maltose were also found in RCC tissue, whereas sugar derivatives such as myo-inositol and scyllo-inositol showed decreased levels. Pathway analysis suggested dysregulation in amino acid, energy (TCA cycle, pyruvate metabolism), sugar, and glutathione metabolism pathways in RCC tissue. Conclusions: These results reveal the metabolic reprogramming related with the development and progression of RCC. Understanding these alterations provides important insights for improving RCC treatment strategies.
description: Scientific Letters, Vol. 1 No. Sup 1 (2024)
Sillago suezensis Golani, Fricke & Tikochinski 2013
Creators: name: Bariche, Michel
name: Fricke, Ronald
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Perciformes
Sillaginidae
Sillago
Sillago suezensis

description: Sillago suezensis Golani, Fricke & Tikochinski 2013 —Suez sillago
Taxonomy. First record from Lebanon as Sillago sihama (Forsskål) by Mouneimné (1977: 62); subsequently recorded as Sillago sihama Forsskål 1775 by Mouneimné (2002: 154); recently recorded as Sillago suezensis by Bariche et al. (2015: 2366); as Sillago suezensis by Fanelli et al. (2015: 2169). Material in collection: AUBM.
Distribution. Northern Red Sea endemic: Gulf of Suez; Mediterranean Sea (Red Sea immigrant). Conservation. IUCN: Global (NE). Capture and threats: Unknown. Occurrence: Very common. Non-indigenous species, no conservation action needed.
description: Published as part of Bariche, Michel & Fricke, Ronald, 2020, The marine ichthyofauna of Lebanon: an annotated checklist, history, biogeography, and conservation status, pp. 1-157 in Zootaxa 4775 (1) on pages 140-141, DOI: 10.11646/zootaxa.4775.1.1, http://zenodo.org/record/3983887
Crenidens crenidens crenidens (Forsskal 1775
Creators: name: Bariche, Michel
name: Fricke, Ronald
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Perciformes
Sparidae
Crenidens
Crenidens crenidens

description: Crenidens crenidens (Forsskål 1775) —Karanteen seabream
Taxonomy. First record from Lebanon as Crenidens crenidens by Bariche et al. (2015: 2366). Material in collection: AUBM (OS3861).
Distribution. Red Sea, western Indian Ocean: East Africa, South Africa and Gulf of Aden east to Socotra and Madagascar; Mediterranean Sea (Red Sea immigrant).
Conservation. IUCN: Global (LC: 1 December 2009). Capture and threats: Unknown. Occurrence: Very rare. Non-indigenous species, no conservation action needed.
description: Published as part of Bariche, Michel & Fricke, Ronald, 2020, The marine ichthyofauna of Lebanon: an annotated checklist, history, biogeography, and conservation status, pp. 1-157 in Zootaxa 4775 (1) on pages 141-142, DOI: 10.11646/zootaxa.4775.1.1, http://zenodo.org/record/3983887
Pelates quadrilineatus
Creators: name: Bariche, Michel
name: Fricke, Ronald
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Perciformes
Terapontidae
Pelates
Pelates quadrilineatus

description: Pelates quadrilineatus (Bloch 1790) —Fourlined terapon
Taxonomy. First record from Lebanon as Pelates quadrilineatus (Bloch) by Mouneimné (1977: 44); subsequently recorded as Pelates quadrilineatus (Bloch 1790) by Mouneimné (2002: 135–136).
Distribution. Red Sea, Indo-West Pacific: East Africa, Madagascar, Mauritius (Mascarenes) and Persian Gulf east to Philippines, New Guinea and Vanuatu, north to southern Japan, south to Western Australia and southeastern Queensland (Australia); Mediterranean Sea (Red Sea immigrant).
Conservation. IUCN: Global (NE). Capture and threats: Unknown. Occurrence: Very rare. Non-indigenous species, no conservation action needed.
description: Published as part of Bariche, Michel & Fricke, Ronald, 2020, The marine ichthyofauna of Lebanon: an annotated checklist, history, biogeography, and conservation status, pp. 1-157 in Zootaxa 4775 (1) on pages 142-143, DOI: 10.11646/zootaxa.4775.1.1, http://zenodo.org/record/3983887
title: The Escape Window As A Management Option To Improve The Size Selectivity Of The Baltic Sea Cod Fishery
Creators: name: Madsen, Niels
name: Holst, Rene
name: Foldager, Leslie
Publisher: name: ASC 1999 - R - Theme session
Year: 2024
Subjects: Fisheries and aquaculture

description: No abstracts are to be cited without prior reference to the author.The square mesh window has been implemented in the legislation for the Baltic Sea cod fishery. This paper reviews the history of the Baltic cod escape windows and presents preliminary results of a recent experiment. The objectives of this experiment were to make a comparison of an escape window with very good selectivity properties to a conventional diamond mesh codend. Three different mesh sizes were tested for each codend. A fixed and random effect model was formulated to analyse the results incorporating recorded variables. The results of this analysis are presented and the potential in escape windows as a management option compared to standard codends is finally discussed.
title: The Peer Review Of Science In The Management Of Living Aquatic Resources
Creators: name: O'Boyle, R.
name: Rice, J.
name: Sinclair, A.
Publisher: name: ASC 1999 - Q - Theme session
Year: 2024
Subjects: Fisheries and aquaculture
Pressures, impacts, conservation, and management

description: No abstracts are to be cited without prior reference to the author.This paper evaluates the nature of peer review in the ICES community, relative to that of journals, of institutions and of other sectors of society (medicine, accounting, etc). From this diversity, we extract the essential features of an effective peer review process. We then consider how the new challenges to the process can be addressed, without compromising these essential features. The evolving Canadian situation, from ICNAF, through the Canadian Atlantic Fisheries Scientific Advisory Committee (CAFSAC), to the current mix of regional, zonal, and national assessment reviews (RAPs, ZAPs, and NAPs), is used to illustrate strengths and weaknesses in each step. From this experience, we provide generalizations for improvements to the current peer review process, both nationally and internationally.
Anticancer drugs and their impact on chemobrain development: an in vitro investigation
Creators: name: Barbosa-Azevedo, Maria
name: Cardoso, Maria
name: Carvalho, Félix
name: Costa, Vera M.
Publisher: name: Scientific Letters
Year: 2024

description: Background: Cancer incidence has been increasing worldwide, over the past few years. “Chemobrain” refers to alterations in cognitive function after cancer treatment, including memory deficits and reduced attention capacity [1]. The blood-brain barrier restricts the entry of certain anticancer drugs into the brain. However, "chemobrain" can also arise from factors extending far beyond direct drug exposure to the brain [1]. Objective: This work aims to access how neurons are affected by different anticancer drugs, such as doxorubicin (DOX), methotrexate (MTX) and sunitinib (SUN), all known to cause clinical cognitive deficits. Methods: Differentiated human neuroblastoma cells (SH-SY5Y) were exposed for 24h or 48h to clinically relevant concentrations of DOX (0.1-10 µM), SUN (1-10 µM) and MTX (5 and 10 µM). Two classical cytotoxicity assays (neutral red uptake and MTT reduction) were performed at the end of the exposure times. In a different paradigm, autophagy inhibitors [3-methyladenine (3-MA) or chloroquine (CLQ)] were used to determine their effects on SUN cytotoxicity. Results: DOX led to concentration-dependent cytotoxicity, which was amplified in the longest exposure time in both assays. On the other hand, MTX caused significant toxicity at 5 µM and 10 µM, which was time-dependent but not concentration-dependent in the MTT reduction assay. In the NR uptake assay, toxicity was seen only on the longest incubation time. Regarding SUN, both assays revealed a time- and concentration-dependent cytotoxicity. For SUN, cells appeared with yellow inclusions and autophagy modulators were used. As for autophagy inhibitors, results were dissimilar, since for SUN 10 µM, 3-MA was partially protective, whereas CLQ significantly increased SUN’s cytotoxicity in both assays at 24h. Conclusions: These findings highlight DOX’s, MTX’s and SUN’s cytotoxicity in neurons, with DOX and SUN being equally potent. Additionally, autophagy inhibitors suggest dysregulation of autophagy as a possible mechanism underlying SUN´s neurotoxicity. Nonetheless, further research is needed.
description: Scientific Letters, Vol. 1 No. Sup 1 (2024)
Terapon puta Cuvier 1829
Creators: name: Bariche, Michel
name: Fricke, Ronald
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Perciformes
Terapontidae
Terapon
Terapon puta

description: Terapon puta Cuvier 1829 —Small-scaled terapon
Taxonomy. First record from Lebanon as Terapon puta by Bariche et al. (2015: 2366); as Terapon puta by Fanelli et al. (2015: 2169). Material in collection: AUBM.
Distribution. Red Sea, Indo-West Pacific: East Africa, Madagascar and Persian Gulf east to Philippines, south to Western Australia and Queensland (Australia); Mediterranean Sea (Red Sea immigrant).
Conservation. IUCN: Global (NE). Capture and threats: Unknown. Occurrence: Common. Non-indigenous species, no conservation action needed.
description: Published as part of Bariche, Michel & Fricke, Ronald, 2020, The marine ichthyofauna of Lebanon: an annotated checklist, history, biogeography, and conservation status, pp. 1-157 in Zootaxa 4775 (1) on page 143, DOI: 10.11646/zootaxa.4775.1.1, http://zenodo.org/record/3983887
Exploring quercetin's potential to counteract intestinal pro-inflammatory effects induced by silver nanoparticles
Creators: name: Sousa, Adelaide
name: Azevedo, Rui
name: Costa, Vera M.
name: Oliveira, Sara
name: Viana, Sofia
name: Reis, Flávio
name: Almeida, Agostinho
name: Matafome, Paulo
name: Dias-Pereira, Patrícia
name: Carvalho, Félix
name: Fernandes, Eduarda
name: Freitas, Marisa
Publisher: name: Scientific Letters
Year: 2024

description: Background: Silver nanoparticles (AgNP) elicit an intestinal response characterized by vascular and cellular changes, alongside the release of cytokines linked to the activation of the nuclear factor-кB (NF-кB) pathway. Consequently, a search was conducted for a compound capable of counteracting the primary pro-inflammatory effects induced by these nanoparticles [1]. Given the reported anti-inflammatory properties of quercetin and its prevalence in the human diet, the use of this compound could be considered a potential strategy for safeguarding the body against the harmful effects of AgNP [2]. Objective: Evaluate the potential protective role of quercetin against the pro-inflammatory effects induced by 5 nm polyvinylpyrrolidone (PVP)-AgNP in C57BL/6J mice. Methods: Two subacute doses of 5 nm PVP-AgNP were orally administered once daily for 14 days using a novel dosing technology (HaPILLness), facilitating stress-free, precise oral dosing. Quercetin (1 mg/kg bw) was concurrently administered via intraperitoneal injection once daily for the same 14-day period. Results: Our findings revealed that quercetin effectively reduced the intestinal inflammatory response caused by AgNP, through a reduction of the vascular and cellular alterations and also a tight regulation of the major NF-кB inflammatory pathway, leading to a notable decrease in cytokine production. Conclusions: This study provides novel insights into the potential role of quercetin in alleviating the intestinal pro-inflammatory effects induced by 5 nm PVP-AgNP.
description: Scientific Letters, Vol. 1 No. Sup 1 (2024)
Toxicity of resin-matrix composites in dentistry
Creators: name: Cordeiro, Maria
name: T. P. C. Gomes, Ana
name: Fidalgo-Pereira, Rita
name: Correia, Patrícia
Publisher: name: Scientific Letters
Year: 2024

description: Background: Resin-matrix composites (RMC) are widely used as restorative materials due to their mechanical, optical, and aesthetic properties. However, some concerns have emerged due to polymerization shrinkage, material degradation, and the release of monomers from the organic matrix, such as the derivatives of bisphenol A (BPA), which are potentially toxic [1-3]. Therefore, it is important to understand the factors that contribute to the incomplete monomer conversion of RMC [1,4].Objective: This systematic review aims to comprehensively explore the factors contributing to the toxicity associated with RMC and to establish clinical criteria that reduce the release of residual monomers. Methods: A systematic review was performed according to the PRISMA criteria. A PICO question was established and three databases, PubMed, Cochrane Central, and Web of Science were selected to run this research. Filters were established to retrieve articles in the last 20 years, in English. The inclusion criteria were in vivostudies/humans, Randomized Controlled Trial (RCT) and toxicity studies. The study characteristics of the included articles were extracted using a predefined Excel file. Results: A total of 1,261 articles were retrieved from the three electronic databases. Following the elimination of duplicates, a total of 1,227 articles remained for further selection by title and abstract, after which 20 articles were subjected to comprehensive reading; 13 articles were included and 7 excluded. The analysis of the selected articles indicated that low levels of monomers were detected in the participants´ saliva and urine, suggesting relatively low local and systemic toxicity. Dental operator-dependent factors were identified. Adherence to RMC placement protocols is essential. Conclusions: This systematic review suggests that low levels of free monomers were detected in participants with RMC and adherence to manufacturer’s instructions is important. Further studies are needed to stablish causality, considering the exposure to non-dental BPA source materials.
description: Scientific Letters, Vol. 1 No. Sup 1 (2024)
title: Effects Of Fishing Power And Competitive Interactions Among Vessels On The Effort Allocation On The Trip Level Of The Dutch Beam Trawl Fleet.
Creators: name: Rijnsdorp, A.D.
name: Dol, W.
name: Hooyer, M.
name: Pastoors, M.A.
Publisher: name: ASC 1999 - R - Theme session
Year: 2024
Subjects: Fisheries and aquaculture

description: No abstracts are to be cited without prior reference to the author.Variations in catch rates in relation to the spatial distribution of beam trawlers were analysed using mandatory logbook data from the Dutch fleet for 1990-1996. Catch rates by trip, corrected for differences in market value of the different species showed a consistent seasonal pattern with highest values during autumn and winter. Catch rates showed a log-linear relationship with engine power, indicating differences in competitive abilities among vessels. In 65% of the fishing trips, catch per unit of effort is equalised among fishing grounds. In the remaining trips, catch rates were below average suggesting that vessels showed exploratory fishing. These results corroborate predictions of the Ideal Free Distribution theory. More powerfull vessels were over­represented on better fishing grounds as compared to less powerful vessels. As a special case the effect of vessel density on catch rate was investigated utilising the opportunity that one segment of the Dutch fleet stayed in port during one week each year ('week of prayer'). The catch rate of vessels that continued fishing was 10% higher than in the week before or following the 'week of prayer'. No such differences were observed. in a reference area exploited only by other segments of the fleet. Implications of this evidence of competitive interactions among vessels in relation to fisheries management are discussed.
In vitro and in silico evaluation of 5-MeO-DMT, LSD, and mescaline’s interaction with CYP450 enzymes
Creators: name: Machado Brito-Da-Costa, Andreia
name: Carvalho, Mariana
name: Dinis-Oliveira, Ricardo Jorge
name: Madureira-Carvalho, Áurea
name: F. Sousa, Sérgio
name: Dias Da Silva, Diana
Publisher: name: Scientific Letters
Year: 2024

description: Background: 5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT), lysergic acid diethylamide (LSD), and mescaline are classic hallucinogens known for their recreational use, which increased in the last decades. Despite some available data on the metabolism of these drugs [1-3], a scientific gap exists regarding their possible interactions with CYP450 enzymes. Nevertheless, this information is of crucial relevance to predict drug-drug interactions and understand toxicological phenomena, in particular interindividual variability. Objective: This study aimed to evaluate in vitro and in silico the interaction of 5-MeO-DMT, LSD, and mescaline with the enzymes CYP2A6/2B6/2D6/2E1/3A4. Methods: The in vitro assessment of CYP450 inhibition was performed using the Vivid®CYP450 screening kits. IC50 was calculated using GraphPad Prism 9.3.0. For in silico assessment, molecular dynamics were performed using the PMEMD.cuda module in AMBER16. Calculations were made on the last 100 ns of the trajectory (stable zone) to assess the interaction mode/strength between enzyme and ligand, namely MMGBSA, per-residue decomposition energy, and hydrogen bonds.Results: Based on the IC50 (mM), LSD (0.35) and 5-MeO-DMT (3.47) present the capacity to be inhibitors of CYP2D6. Based on the MMGBSA (kcal/mol), LSD showed the highest binding affinities for all enzymes, while mescaline showed the lowest. The strong interaction of LSD with CYP2A6 is mediated by a hydrogen bond established with the protein residue Asn297. For interaction with CYP2B6, the residues Thr302 and Lys479 were important in mediating the interaction with 5-MeO-DMT and LSD. Key residues mediating the interaction of 5-MeO-DMT and LSD with CYP2D6 included Phe120, Leu213, and Phe483. For interaction with CYP2E1, residues Phe207, Phe298, and Thr303 are important; and for CYP3A4, an important hydrogen bond between LSD and Ala370 was identified. Conclusions: Both LSD and 5-MeO-DMT are predicted to have strong potential to be CYP2D6 inhibitors. A strong interaction was also identified in silico between LSD and CYP2A6.
description: Scientific Letters, Vol. 1 No. Sup 1 (2024)