An open dataset of <i>Plasmodium vivax</i> genome variation in 1,895 worldwide samples.
Creators: name: Adam, Ishag
name: Alam, Mohammad Shafiul
name: Alemu, Sisay
name: Amaratunga, Chanaki
name: Amato, Roberto
name: Andrianaranjaka, Voahangy
name: Anstey, Nicholas M
name: Aseffa, Abraham
name: Ashley, Elizabeth
name: Assefa, Ashenafi
name: Auburn, Sarah
name: Barber, Bridget E
name: Barry, Alyssa
name: Batista Pereira, Dhelio
name: Cao, Jun
name: Chau, Nguyen Hoang
name: Chotivanich, Kesinee
name: Chu, Cindy
name: Dondorp, Arjen M
name: Drury, Eleanor
name: Echeverry, Diego F
name: Erko, Berhanu
name: Espino, Fe
name: Fairhurst, Rick
name: Faiz, Abdul
name: Fernanda Villegas, María
name: Gao, Qi
name: Golassa, Lemu
name: Goncalves, Sonia
name: Grigg, Matthew J
name: Hamedi, Yaghoob
name: Hien, Tran Tinh
name: Htut, Ye
name: Johnson, Kimberly J
name: Karunaweera, Nadira
name: Khan, Wasif
name: Krudsood, Srivicha
name: Kwiatkowski, Dominic P
name: Lacerda, Marcus
name: Ley, Benedikt
name: Lim, Pharath
name: Liu, Yaobao
name: Llanos-Cuentas, Alejandro
name: Lon, Chanthap
name: Lopera-Mesa, Tatiana
name: Marfurt, Jutta
name: Michon, Pascal
name: Miotto, Olivo
name: Mohammed, Rezika
name: Mueller, Ivo
name: Namaik-Larp, Chayadol
name: Newton, Paul N
name: Nguyen, Thuy-Nhien
name: Nosten, Francois
name: Noviyanti, Rintis
name: Pava, Zuleima
name: Pearson, Richard D
name: Petros, Beyene
name: Phyo, Aung P
name: Price, Ric N
name: Pukrittayakamee, Sasithon
name: Rahim, Awab Ghulam
name: Randrianarivelojosia, Milijaona
name: Rayner, Julian C
name: Rumaseb, Angela
name: Siegel, Sasha V
name: Simpson, Victoria J
name: Thriemer, Kamala
name: Tobon-Castano, Alberto
name: Trimarsanto, Hidayat
name: Urbano Ferreira, Marcelo
name: Vélez, Ivan D
name: Wangchuk, Sonam
name: Wellems, Thomas E
name: White, Nicholas J
name: William, Timothy
name: Yasnot, Maria F
name: Yilma, Daniel
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Malaria
Genomics
Plasmodium vivax
Genomic Epidemiology
Data Resource

description: This report describes the MalariaGEN Pv4 dataset, a new release of curated genome variation data on 1,895 samples of <i>Plasmodium vivax</i> collected at 88 worldwide locations between 2001 and 2017. It includes 1,370 new samples contributed by MalariaGEN and VivaxGEN partner studies in addition to previously published samples from these and other sources. We provide genotype calls at over 4.5 million variable positions including over 3 million single nucleotide polymorphisms (SNPs), as well as short indels and tandem duplications. This enlarged dataset highlights major compartments of parasite population structure, with clear differentiation between Africa, Latin America, Oceania, Western Asia and different parts of Southeast Asia. Each sample has been classified for drug resistance to sulfadoxine, pyrimethamine and mefloquine based on known markers at the <i>dhfr</i>, <i>dhps</i> and <i>mdr1</i> loci. The prevalence of all of these resistance markers was much higher in Southeast Asia and Oceania than elsewhere. This open resource of analysis-ready genome variation data from the MalariaGEN and VivaxGEN networks is driven by our collective goal to advance research into the complex biology of <i>P. vivax</i> and to accelerate genomic surveillance for malaria control and elimination.