cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
HI-to-H2 Transitions in the Perseus Molecular Cloud
Creators: name: Bialy, Shmuel
name: Sternberg, Amiel
name: Lee, Min-Young
name: Petit, Franck Le
name: Roueff, Evelyne
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We use the Sternberg et al. (2014) theory for interstellar atomic to molecular (HI-to-H$_2$) conversion to analyze HI-to-H$_2$ transitions in five (low-mass) star-forming and dark regions in the Perseus molecular cloud, B1, B1E, B5, IC348, and NGC1333. The observed HI mass surface densities of 6.3 to 9.2 M$_{\odot}$ pc$^{-2}$ are consistent with HI-to-H$_2$ transitions dominated by HI-dust shielding in predominantly atomic envelopes. For each source, we constrain the dimensionless parameter $αG$, and the ratio $I_{\rm UV}/n$, of the FUV intensity to hydrogen gas density. We find $αG$ values from 5.0 to 26.1, implying characteristic atomic hydrogen densities 11.8 to 1.8 cm$^{-3}$, for $I_{\rm UV} \approx 1$ appropriate for Perseus. Our analysis implies that the dusty HI shielding layers are probably multiphased, with thermally unstable UNM gas in addition to cold CNM within the 21 cm kinematic radius.
description: 5 pages, 2 Figures. Minor improvements suggested by the referee. Accepted for publication in the Astrophysical Journal
Androgen-induced NH 2 - and COOH-terminal Interaction Inhibits p160 Coactivator Recruitment by Activation Function 2
Creators: name: Wilson, Elizabeth M.
name: He, Bin
name: Bowen, Natalie T.
name: Minges, John T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: The androgen receptor undergoes an androgen-specific NH(2)- and COOH-terminal interaction between NH(2)-terminal motif FXXLF and activation function 2 in the ligand binding domain. We demonstrated previously that activation function 2 forms overlapping binding sites for the androgen receptor FXXLF motif and the LXXLL motifs of p160 coactivators. Here we investigate the influence of the NH(2)- and COOH-terminal interaction on androgen receptor function. Specificity and relative potency of the motif interactions were evaluated by ligand dissociation rate and the stability of chimeras of transcriptional intermediary factor 2 with full-length and truncated androgen or glucocorticoid receptor. The results indicate that the androgen receptor activation function 2 interacts specifically and with greater avidity with the single FXXLF motif than with the LXXLL motif region of p160 coactivators, whereas this region of the glucocorticoid receptor interacts preferentially with the LXXLL motifs. Expression of the LXXLL motifs as a fusion protein with the glucocorticoid receptor resulted in loss of agonist-induced receptor destabilization and increased half-time of ligand dissociation. The NH(2)- and COOH-terminal interaction inhibited binding and activation by transcriptional intermediary factor 2. We conclude that the androgen receptor NH(2)- and COOH-terminal interaction reduces the dissociation rate of bound androgen, stabilizes the receptor, and inhibits p160 coactivator recruitment by activation function 2.
Supplementary material from Modelling determinants of extinction across two Mesozoic hyperthermal events.
Creators: name: Dunhill, Alexander M.
name: Foster, William J.
name: Azaele, Sandro
name: Sciberras, James
name: Twitchett, Richard J.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences

description: supplementary tables and modelling code and outputs
The critical phenomena of a single defect
Creators: name: Wu, Xintian
name: Zhang, Yangyang
Publisher: name: arXiv
Year: 2015
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We consider the critical system with a point defect and study the variation of thermodynamic quantities, which are the differences between those with and without the defect. Within renormalization group theory, we show generally that the critical exponent of the internal energy variation is the specific heat exponent of a pure system, and the critical exponent of the heat capacity variation is that for the temperature derivative of specific heat of a pure system. This conclusion is valid for the isotropic systems with a short-range interaction. As an example we solve the two dimensional Ising model with a point defect numerically. The variations of the free energy, internal energy and specific heat are calculated with bond propagation algorithm. At the critical point, the internal energy variation diverges with the lattice size logarithmically and the heat capacity variation diverges with size linearly. Near the critical point, the internal energy variation behaves as $\ln |t|$ and the heat capacity variation behaves as $|t|^{-1}$, where $t$ is the reduced temperature.
Finding a unique texture for quark mass matrices
Creators: name: Sharma, Samandeep
name: Fakay, Priyanka
name: Ahuja, Gulsheen
name: Gupta, Manmohan
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Within the Standard Model, starting with the most general mass matrices we have used the facility of making weak basis transformations and have imposed the condition of `naturalness' to carry out their analysis within the texture zero approach. Interestingly, our analysis reveals that a particular set of texture 4 zero quark mass matrices can be considered to be a unique viable option for the description of quark mixing data.
description: 9 pages, 2 figures
D1.2 Details and agreements for accessing the selected data sources
Creators: name: University Of Parma
name: Aristotle University Of Thessaloniki
name: Cooperativas Agro-Alimentarias
name: Institute Of Agrophysics (IA PAS)
name: Idener
name: University Of Science And Technology In Bydgoszcz
Publisher: name: Zenodo
Year: 2021
Subjects: AGRICORE H2020

description: Because the process of gaining access to non-publicly available data of interest of the researcher(s) willing to undertake an Impact Assessment (IA) of the (changes in) agricultural policy either at the national or international level might be significantly time-consuming, Deliverable 1.2 provides the researcher wishing to gain access to selected non-publicly available datasets with a few details on the administrative and bureaucratic processes she needs to undertake to complete the necessary requests for access. Therefore, Deliverable 1.2 hopes to help the research community in planning, and possibly speeding up, the process of acquiring (selected) non-publicly available datasets of possible interest, such that sufficient time and resources are allocated to this activity and the overall research effort might be more adequate and effective.
 Deliverable 1.2 presents evidence of the need for relying on non-publicly available data for the modelling and the IA of (changes in the) agricultural policy, especially if undertaken at the EU or (whole) national level. Because of the scope and objectives of the AGRICORE Project, which foresees the implementation and demonstration of the AGRICORE suite in two national (UC2 and UC3) and one regional (UC1) Use Cases (UCs), the data required exceed those provided in the national or EU version of the FADN. The latter are frequently employed by agricultural economists in their modelling and IA of (changes in the) agricultural policy. The attribute of interest for the construction of the AGRICORE agent include also soil and climatic characteristics which, for instance, in Poland are not publicly available and obtaining access to them is demonstrably taking a long time and requiring significant effort.
 Deliverable 1.2 has documented the extent to which the strong personal and professional relationships developed over time by reputable researchers, often involved in collaborative projects like the H2020 Project AGRICORE, facilitates gaining access to otherwise non-publicly available datasets. Despite the personal contact details of the people who were crucial in giving access to the data could not be shared in this Deliverable for obvious confidentiality and privacy reasons, the partners of the AGRICORE Consortium involved in retrieving the datasets described above remain available to reputable members of the scientific community to facilitate the successful completion of similar requests.
Anti-Fas Induces Hepatic Chemokines and Promotes Inflammation by an NF-κB-independent, Caspase-3-dependent Pathway
Creators: name: Schrum, Laura W.
name: Burckhardt, Beat E.
name: Maher, Jacquelyn J.
name: Rippe, Richard A.
name: Campe, Carson B.
name: Hanson, Jennifer C.
name: Faouzi, Saadia
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Agonistic antibodies against the Fas receptor, when administered to mice in vivo, cause significant apoptosis in the liver. In this study we show that anti-Fas antibody not only causes apoptosis of liver cells but also provokes hepatic inflammation. Two hours after injection of anti-Fas, when mice displayed evidence of caspase-3 activation and apoptosis, we found significant hepatic induction of the CXC chemokines macrophage inflammatory protein-2 and KC. Coincident with the chemokine induction was infiltration of the hepatic parenchyma by neutrophils. Neutralization experiments identified that chemokines were the cause of Fas-induced hepatic inflammation, with KC having the predominant effect. Chemokine induction in the livers of anti-Fas-treated mice was not associated with activation of NF-kappa B. Instead, it coincided with nuclear translocation of activator protein-1 (AP-1). AP-1 activation in liver was detected 1-2 h after anti-Fas treatment, suggesting a connection to the onset of apoptosis. When apoptosis was prevented by pretreating mice with a caspase-3 inhibitor, AP-1 activation and hepatic chemokine production were both significantly reduced. Hepatic inflammation was also reduced by 70%. Taken together, these findings indicate that Fas ligation can induce inflammation in the liver in vivo. Inflammation does not arise from Fas-mediated signaling through NF-kappa B; rather, it represents an indirect effect, requiring activation of caspase-3 and nuclear translocation of AP-1.
Defining disablist hate crime: acts, mis/constructions, and the process of othering.
Creators: name: Houghton, Valerie
Publisher: name: Lancaster University
Year: 2023
Subjects: disability hate crime
acts
construction
process of othering

description: Disabled people are harassed, exploited, and assaulted, by strangers, neighbours, carers, family, and friends. These acts are disablist hate crimes, but few are recognised, reported, or prosecuted. Thus, we know little about their nature; nor how to best prevent, interrupt, or respond. This research aims to fill these knowledge gaps. As so little is known, the research is inductive, using grounded theory methods to analyse almost a hundred cases of disablist hate crime from police reports, interviews with safeguarding practitioners, and published case investigations. From this rich analysis, anchored in the data, a new typology is developed of disablist hate crime with three major categories: i) intimidation, ii) exploitation, and iii) extensive control; and from this a new typology of perpetrators is posited. Disablist hate crime is constructed as a dynamic process of othering in which perpetrators define disabled people as being different, as vulnerable, and as targets for brutalisation and exploitation. The context of this process is explored focusing on its interactional nature, and two perpetrator communities are identified: i) marginalised neighbourhoods, and ii) abusive care settings. Finally, the construction of disablist hate crime by agents of social justice1 is explored. The (mis)constructions of disablist hate crime as micro-aggressions, inside jobs, and of the less-than-ideal victim, are identified as operational and theoretical obstacles for disabled people in accessing justice. These findings suggest both individual and structural disablism within institutions of social justice involved in the social construction of disablist hate crime. We are failing disabled people; failing to offer effective prevention, timely intervention, and access to justice which disempowers, and retraumatises disabled people. I conclude my thesis by suggesting that reframing disablist hate crime offers a timely perspective on thinking about all forms of hate crime and hate crime law.
Supplementary Methods from Vertebral morphometrics and lung structure in non-avian dinosaurs
Creators: name: Brocklehurst, Robert J.
name: Schachner, Emma R.
name: Sellers, William I.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences

description: Tables containing the full lists of extant and extinct taxa used in this study, as well as a detailed description of the landmark scheme.
Cadherin Engagement Regulates Rho family GTPases
Creators: name: Gumbiner, Barry M.
name: Niessen, Carien M.
name: Burridge, Keith
name: Noren, Nicole K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: The formation of cell-cell adherens junctions is a cadherin-mediated process associated with reorganization of the actin cytoskeleton. Because Rho family GTPases regulate actin dynamics, we investigated whether cadherin-mediated adhesion regulates the activity of RhoA, Rac1, and Cdc42. Confluent epithelial cells were found to have elevated Rac1 and Cdc42 activity but decreased RhoA activity when compared with low density cultures. Using a calcium switch method to manipulate junction assembly, we found that induction of cell-cell junctions increased Rac1 activity, and this was inhibited by E-cadherin function-blocking antibodies. Using the same calcium switch procedure, we found little effect on RhoA activity during the first hour of junction assembly. However, over several hours, RhoA activity significantly decreased. To determine whether these effects are mediated directly through cadherins or indirectly through engagement of other surface proteins downstream from junction assembly, we used a model system in which cadherin engagement is induced without cell-cell contact. For these experiments, Chinese hamster ovary cells expressing C-cadherin were plated on the extracellular domain of C-cadherin immobilized on tissue culture plates. Whereas direct cadherin engagement did not stimulate Cdc42 activity, it strongly inhibited RhoA activity but increased Rac1 activity. Deletion of the C-cadherin cytoplasmic domain abolished these effects.
(1791) John Holmes Houston
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Wide-Field Lensing Mass Maps from DES Science Verification Data
Creators: name: Chang, C.
name: Vikram, V.
name: Jain, B.
name: Bacon, D.
name: Amara, A.
name: Becker, M. R.
name: Bernstein, G.
name: Bonnett, C.
name: Bridle, S.
name: Brout, D.
name: Busha, M.
name: Frieman, J.
name: Gaztanaga, E.
name: Hartley, W.
name: Jarvis, M.
name: Kacprzak, T.
name: Kovacs, A.
name: Lahav, O.
name: Lin, H.
name: Melchior, P.
name: Peiris, H.
name: Rozo, E.
name: Rykoff, E.
name: Sanchez, C.
name: Sheldon, E.
name: Troxel, M. A.
name: Wechsler, R.
name: Zuntz, J.
name: Abbott, T.
name: Abdalla, F. B.
name: Allam, S.
name: Annis, J.
name: Bauer, A. H.
name: Benoit-Levy, A.
name: Brooks, D.
name: Buckley-Geer, E.
name: Burke, D. L.
name: Capozzi, D.
name: Rosell, A. Carnero
name: Kind, M. Carrasco
name: Castander, F. J.
name: Crocce, M.
name: D'Andrea, C. B.
name: Desai, S.
name: Diehl, H. T.
name: Dietrich, J. P.
name: Doel, P.
name: Eifler, T. F.
name: Evrard, A. E.
name: Neto, A. Fausti
name: Flaugher, B.
name: Fosalba, P.
name: Gruen, D.
name: Gruendl, R. A.
name: Gutierrez, G.
name: Honscheid, K.
name: James, D.
name: Kent, S.
name: Kuehn, K.
name: Kuropatkin, N.
name: Maia, M. A. G.
name: March, M.
name: Martini, P.
name: Merritt, K. W.
name: Miller, C. J.
name: Miquel, R.
name: Neilsen, E.
name: Nichol, R. C.
name: Ogando, R.
name: Plazas, A. A.
name: Romer, A. K.
name: Roodman, A.
name: Sako, M.
name: Sanchez, E.
name: Sevilla, I.
name: Smith, R. C.
name: Soares-Santos, M.
name: Sobreira, F.
name: Suchyta, E.
name: Tarle, G.
name: Thaler, J.
name: Thomas, D.
name: Tucker, D.
name: Walker, A. R.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present a mass map reconstructed from weak gravitational lensing shear measurements over 139 sq. deg from the Dark Energy Survey (DES) Science Verification data. The mass map probes both luminous and dark matter, thus providing a tool for studying cosmology. We find good agreement between the mass map and the distribution of massive galaxy clusters identified using a red-sequence cluster finder. Potential candidates for super-clusters and voids are identified using these maps. We measure the cross-correlation between the mass map and a magnitude-limited foreground galaxy sample and find a detection at the 5-7 sigma level on a large range of scales. These measurements are consistent with simulated galaxy catalogs based on LCDM N-body simulations, suggesting low systematics uncertainties in the map. We summarize our key findings in this letter; the detailed methodology and tests for systematics are presented in a companion paper.
description: 7 pages, 3 figures, 1 table; accepted to PRL
Cell Adhesion Regulates the Interaction between Nck and p21-activated Kinase
Creators: name: Howe, Alan K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: The p21-activated kinases (PAKs) are important mediators of cytoskeletal reorganization, cell motility and transcriptional events regulated by the Rho family GTPases Rac and Cdc42. PAK activation by serum components is strongly dependent on cell adhesion to the extracellular matrix (ECM). PAK binds directly to the Nck adapter protein, an interaction thought to play an important role in regulation and localization of PAK activity. This report demonstrates that the interaction of PAK with Nck is regulated dynamically by cell adhesion. PAK-Nck binding is rapidly lost after cell detachment and rapidly restored after re-adhesion to the ECM protein fibronectin, suggesting a rapidly reversible mode of regulation. Furthermore, the loss of Nck binding correlates with changes in the phosphorylation state of PAK in nonadherent cells, as evidenced by electrophoretic mobility shift and phosphorylation within a sequence known to mediate interaction with Nck. The ability of cell adhesion to regulate PAK phosphorylation and interaction with Nck may contribute to the anchorage-dependence of PAK activation as well as to the localization of activated PAK within a cell.
D1.3 Characterisation of EU and other supranational statistics datasets
Creators: name: University Of Parma
name: Aristotle University Of Thessaloniki
name: Akdeniz University
name: Institute Of Agrophysics (IA PAS)
name: Bydgoszcz University Of Science And Technology
Publisher: name: Zenodo
Year: 2022
Subjects: AGRICORE H2020

description: This deliverable presents the methodology defined within the AGRICORE project to characterise socio-economic statistical data sources useful for performing agricultural research analysis. This methodology has been developed as part of the first of the work packages defined in the AGRICORE project. AGRICORE is a research project proposing an innovative way to apply agentbased modelling to improve the capacities of policymakers to evaluate the impact of agriculturalrelated measurements under and outside the framework of the Common Agricultural Policy. This project was funded by the European Commission as a result of the RUR-04-2018 call, part of the H2020 programme. In the introduction, the basis on which the methodology has been developed is presented, i.e., the ARDIT tool and the AGRICORE DCAT-AP 2.0 ontology. Then, the proposed methodology is detailed including also the definition of all the fields to be filled while characterising a dataset in ARDIT. As part of this methodology, also all the main challenges encountered during the characterisation of the datasets have been explained, illustrating the proposed solutions. After that, also the methodology proposed to guarantee that the tool ARDIT remains efficiently working is described, relying on a continuous upgrade and maintenance of the data. Finally, some conclusions regarding the characterisation process and the need for a governance strategy to ensure the survival of the ARDIT after the project are provided. It is important to remark that although this deliverable has been developed in the framework of the AGRICORE project, the participating partners have aimed for broader usage of the proposed methodology. As the final goal of this work package, the proposed EU Index Tool (now renamed as Agricultural Research Data Index Tool (ARDIT) aims to serve as a central entry point for locating useful datasets useful for agricultural research
(1792) James Alexander Scarlett
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Interactive Restless Multi-armed Bandit Game and Swarm Intelligence Effect
Creators: name: Yoshida, Shunsuke
name: Hisakado, Masato
name: Mori, Shintaro
Publisher: name: arXiv
Year: 2015
Subjects: subject: Artificial Intelligence (cs.AI)
subject: Machine Learning (cs.LG)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: We obtain the conditions for the emergence of the swarm intelligence effect in an interactive game of restless multi-armed bandit (rMAB). A player competes with multiple agents. Each bandit has a payoff that changes with a probability $p_{c}$ per round. The agents and player choose one of three options: (1) Exploit (a good bandit), (2) Innovate (asocial learning for a good bandit among $n_{I}$ randomly chosen bandits), and (3) Observe (social learning for a good bandit). Each agent has two parameters $(c,p_{obs})$ to specify the decision: (i) $c$, the threshold value for Exploit, and (ii) $p_{obs}$, the probability for Observe in learning. The parameters $(c,p_{obs})$ are uniformly distributed. We determine the optimal strategies for the player using complete knowledge about the rMAB. We show whether or not social or asocial learning is more optimal in the $(p_{c},n_{I})$ space and define the swarm intelligence effect. We conduct a laboratory experiment (67 subjects) and observe the swarm intelligence effect only if $(p_{c},n_{I})$ are chosen so that social learning is far more optimal than asocial learning.
description: 18 pages, 4 figures
CHIP Is a U-box-dependent E3 Ubiquitin Ligase: IDENTIFICATION OF Hsc70 AS A TARGET FOR UBIQUITYLATION
Creators: name: Dai, Qian
name: Wu, Yaxu
name: Cyr, Douglas M.
name: Ballinger, Carol A.
name: Patterson, Cam
name: Höhfeld, Jörg
name: Jiang, Jihong
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Proper folding of proteins (either newly synthesized or damaged in response to a stressful event) occurs in a highly regulated fashion. Cytosolic chaperones such as Hsc/Hsp70 are assisted by cofactors that modulate the folding machinery in a positive or negative manner. CHIP (carboxyl terminus of Hsc70-interacting protein) is such a cofactor that interacts with Hsc70 and, in general, attenuates its most well characterized functions. In addition, CHIP accelerates ubiquitin-dependent degradation of chaperone substrates. Using an in vitro ubiquitylation assay with recombinant proteins, we demonstrate that CHIP possesses intrinsic E3 ubiquitin ligase activity and promotes ubiquitylation. This activity is dependent on the carboxyl-terminal U-box. CHIP interacts functionally and physically with the stress-responsive ubiquitin-conjugating enzyme family UBCH5. Surprisingly, a major target of the ubiquitin ligase activity of CHIP is Hsc70 itself. CHIP ubiquitylates Hsc70, primarily with short, noncanonical multiubiquitin chains but has no appreciable effect on steady-state levels or half-life of this protein. This effect may have heretofore unanticipated consequences with regard to the chaperoning activities of Hsc70 or its ability to deliver substrates to the proteasome. These studies demonstrate that CHIP is a bona fide ubiquitin ligase and indicate that U-box-containing proteins may comprise a new family of E3s.
Supplementary material from Modelling determinants of extinction across two Mesozoic hyperthermal events
Creators: name: Dunhill, Alexander M.
name: Foster, William J.
name: Azaele, Sandro
name: Sciberras, James
name: Twitchett, Richard J.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: 40308 Palaeontology (incl. Palynology)
subject: FOS: Earth and related environmental sciences

description: supplementary tables and modelling code and outputs
Efficient data structures for masks on 2D grids
Creators: name: Reinecke, Martin
name: Hivon, Eric
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: This article discusses various methods of representing and manipulating arbitrary coverage information in two dimensions, with a focus on space- and time-efficiency when processing such coverages, storing them on disk, and transmitting them between computers. While these considerations were originally motivated by the specific tasks of representing sky coverage and cross-matching catalogues of astronomical surveys, they can be profitably applied in many other situations as well.
description: accepted by A&A
Supplementary Information from Temperature-mediated inhibition of a bumblebee parasite by an intestinal symbiont.
Creators: name: Palmer-Young, Evan C.
name: Raffel, Thomas R.
name: McFrederick, Quinn S.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Ecology
subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: Supplementary Figures, Tables, and Methods
Class I Major Histocompatibility Complex Anchor Substitutions Alter the Conformation of T Cell Receptor Contacts
Creators: name: Collins, Edward J.
name: Kuhns, Jennifer J.
name: Friedline, Randall H.
name: Long, Brian
name: Yan, Shuqin
name: Tisch, Roland
name: Sharma, Ashwani K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: An immunogenic peptide (GP2) derived from HER-2/neu binds to HLA-A2.1 very poorly. Some altered-peptide ligands (APL) of GP2 have increased binding affinity and generate improved cytotoxic T lymphocyte recognition of GP2-presenting tumor cells, but most do not. Increases in binding affinity of single-substitution APL are not additive in double-substitution APL. A common first assumption about peptide binding to class I major histocompatibility complex is that each residue binds independently. In addition, immunologists interested in immunotherapy frequently assume that anchor substitutions do not affect T cell receptor contact residues. However, the crystal structures of two GP2 APL show that the central residues change position depending on the identity of the anchor residue(s). Thus, it is clear that subtle changes in the identity of anchor residues may have significant effects on the positions of the T cell receptor contact residues.
Classes of Thiols That Influence the Activity of the Skeletal Muscle Calcium Release Channel
Creators: name: Stamler, Jonathan S.
name: Meissner, Gerhard
name: Sun, Junhui
name: Xu, Le
name: Eu, Jerry P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: The skeletal muscle Ca(2+) release channel/ryanodine receptor (RyR1) is a prototypic redox-responsive ion channel. Nearly half of the 101 cysteines per RyR1 subunit are kept in a reduced (free thiol) state under conditions comparable with resting muscle. Here we assessed the effects of physiological determinants of cellular redox state (oxygen tension, reduced (GSH) or oxidized (GSSG) glutathione, and NO/O(2) (released by 3-morpholinosydnonimine)) on RyR1 redox state and activity. Oxidation of approximately 10 RyR1 thiols (from approximately 48 to approximately 38 thiols/RyR1 subunit) had little effect on channel activity. Channel activity increased reversibly as the number of thiols was further reduced to approximately 23/subunit, whereas more extensive oxidation (to approximately 13 thiols/subunit) inactivated the channel irreversibly. Neither S-nitrosylation nor tyrosine nitration contributed to these effects. The results identify at least three functional classes of RyR1 thiols and suggest that 1) the channel may be protected from oxidation by a large reservoir of functionally inert thiols, 2) the channel may be designed to respond to moderate oxidative stress by a change in activation setpoint, and 3) the channel is susceptible to oxidative injury under more extensive conditions.
(1789) Matthew Blakiston
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Crystal Structure of a Deacylation-defective Mutant of Penicillin-binding Protein 5 at 2.3-Å Resolution
Creators: name: Nicholas, Robert A.
name: Davies, Christopher
name: White, Stephen W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Penicillin-binding protein 5 (PBP 5) of Escherichia coli functions as a d-alanine carboxypeptidase, cleaving the C-terminal d-alanine residue from cell wall peptides. Like all PBPs, PBP 5 forms a covalent acyl-enzyme complex with beta-lactam antibiotics; however, PBP 5 is distinguished by its high rate of deacylation of the acyl-enzyme complex (t(12) approximately 9 min). A Gly-105 --> Asp mutation in PBP 5 markedly impairs this beta-lactamase activity (deacylation), with only minor effects on acylation, and promotes accumulation of a covalent complex with peptide substrates. To gain further insight into the catalytic mechanism of PBP 5, we determined the three-dimensional structure of the G105D mutant form of soluble PBP 5 (termed sPBP 5') at 2.3 A resolution. The structure is composed of two domains, a penicillin binding domain with a striking similarity to Class A beta-lactamases (TEM-1-like) and a domain of unknown function. In addition, the penicillin-binding domain contains an active site loop spatially equivalent to the Omega loop of beta-lactamases. In beta-lactamases, the Omega loop contains two amino acids involved in catalyzing deacylation. This similarity may explain the high beta-lactamase activity of wild-type PBP 5. Because of the low rate of deacylation of the G105D mutant, visualization of peptide substrates bound to the active site may be possible.
Broken Time Reversal Symmetry in Superconducting Pr1-xCexPt4Ge12
Creators: name: Zhang, Jian
name: MacLaughlin, D. E.
name: Hillier, A. D.
name: Ding, Z. F.
name: Huang, K.
name: Maple, M. B.
name: Shu, Lei
Publisher: name: arXiv
Year: 2015
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We report results of zero-field muon spin relaxation experiments on the filled-skutterudite superconductors~Pr$_{1-x}$Ce$_{x}$Pt$_4$Ge$_{12}$, $x = 0$, 0.07, 0.1, and 0.2, to investigate the effect of Ce doping on broken time-reversal symmetry (TRS) in the superconducting state. In these alloys broken TRS is signaled by the onset of a spontaneous static local magnetic field~$B_s$ below the superconducting transition temperature. We find that $B_s$ decreases linearly with $x$ and $\to 0$ at $x \approx 0.4$, close to the concentration above which superconductivity is no longer observed. The (Pr,Ce)Pt$_4$Ge$_{12}$ and isostructural (Pr,La)Os$_4$Sb$_{12}$ alloy series both exhibit superconductivity with broken TRS, and in both the decrease of $B_s$ is proportional to the decrease of Pr concentration. This suggests that Pr-Pr intersite interactions are responsible for the broken TRS\@. The two alloy series differ in that the La-doped alloys are superconducting for all La concentrations, suggesting that in (Pr,Ce)Pt$_4$Ge$_{12}$ pair-breaking by Ce doping suppresses superconductivity. For all $x$ the dynamic muon spin relaxation rate decreases somewhat in the superconducting state. This may be due to Korringa relaxation by conduction electrons, which is reduced by the opening of the superconducting energy gap.
description: Accepted by Phys. Rev. B
Differential Regulation of the Uridine Nucleotide-activated P2Y4 and P2Y6 Receptors: SER-333 AND SER-334 IN THE CARBOXYL TERMINUS ARE INVOLVED IN AGONIST-DEPENDENT PHOSPHORYLATION DESENSITIZATION AND INTERNALIZATION OF THE P2Y4 RECEPTOR
Creators: name: Harden, T. Kendall
name: Brinson, Amy E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Agonist-promoted regulation of the uridine nucleotide-activated human P2Y4 receptor (P2Y4-R) and P2Y6 receptor (P2Y6-R) was studied. Incubation of P2Y4-R-expressing 1321N1 human astrocytoma cells with the cognate agonist UTP resulted in rapid desensitization of the inositol phosphate response and a 50% loss of cell surface receptors. In contrast, incubation of P2Y6-R-expressing cells with the cognate agonist UDP caused neither rapid desensitization nor rapid loss of cell surface receptors. Removal of UTP from the medium of UTP-pretreated cells resulted in rapid and complete recovery of surface P2Y4-R even after 12 h of agonist treatment. Although extended incubation with UDP also caused a loss of surface P2Y6-R, rapid recovery of surface P2Y6-R did not occur following removal of agonist. Pharmacological studies indicated that neither protein kinase C nor other Ca(2+)-activated kinases were involved in agonist-promoted desensitization or loss of surface P2Y4-R or P2Y6-R. Mutational analyses were carried out to identify domains involved in agonist-dependent regulation of P2Y4-R. Sequential truncation of the carboxyl-terminal domain revealed that sequence between amino acids 332 and 343 was necessary for UTP-promoted desensitization and internalization. Further mutational analyses of the three serines in this domain confirmed that Ser-333 and Ser-334 play a major role in these agonist-promoted changes in P2Y4-R. Experiments were carried out with [(32)P]P(i)-labeled cells to ascertain the role of phosphorylation in regulation of P2Y4-R. Incubation with UTP for 2 min caused a marked increase in phosphorylation of both the wild-type P2Y4-R and the P2Y4-343 truncation mutant. In contrast, no UTP-promoted phosphorylation of the P2Y4-332 truncation mutant was observed. Taken together, these results demonstrate differential regulation of uridine nucleotide-activated P2Y4-R and P2Y6-R and indicate that Ser-333 and Ser-334 in the carboxyl terminus of P2Y4-R are important for UTP-dependent phosphorylation, desensitization, and loss of surface receptors.
Supplementary Information from Temperature-mediated inhibition of a bumblebee parasite by an intestinal symbiont
Creators: name: Palmer-Young, Evan C.
name: Raffel, Thomas R.
name: McFrederick, Quinn S.
Publisher: name: The Royal Society
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Ecology
subject: Health Care
subject: Diseases
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: Supplementary Figures, Tables, and Methods
Dissecting a Charged Network at the Active Site of Orotidine-5′-phosphate Decarboxylase
Creators: name: Wolfenden, Richard
name: Short, Steven A.
name: Snider, Mark J.
name: Miller, Brian G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: The crystal structure of yeast orotidine-5'-phosphate decarboxylase in complex with the postulated transition state analog, 6-hydroxyuridine-5'-phosphate, reveals contacts between this inhibitor and a novel quartet of charged residues (Lys-59, Asp-91, Lys-93, and Asp-96) within the active site. The structure also suggests a possible interaction between O2 of the 6-hydroxyuridine-5'-phosphate pyrimidine ring and Gln-215. Here we report the results of mutagenesis of each of the charged active site residues and Gln-215. The activities of the Q215A and wild-type enzymes were equal indicating that any interactions between this residue and the pyrimidine ring are dispensable for efficient decarboxylation. For the D91A and K93A mutant enzymes, activity was reduced by more than 5 orders of magnitude and substrate binding could not be detected by isothermal calorimetry. For the D96A mutant enzyme, k(cat) was reduced by more than 5 orders of magnitude, and isothermal calorimetry indicated an 11-fold decrease in the affinity of this enzyme for the substrate in the ground state. For the K59A enzyme, k(cat) was reduced by a factor of 130, and K(m) had increased by a factor of 900. These results indicate that the integrity of the network of charged residues is essential for transition state stabilization.
COME RES Deliverable 3.4 Consultation series of the eight country desks. Summary Report
Creators: name: Standal, Karina
name: Ytreberg, Nora Svarstad
name: Alonso, Irene
name: Azevedo, Isabel
name: Bastian, Massimo
name: Di Nucci, Maria Rosaria
name: Dyląg, Anna
name: Gatta, Vincenzo
name: Klāvs, Gaidis
name: Krug, Michael
name: Kudrenickis, Ivars
name: Laes, Erik
name: Maleki, Pouyan
name: Van Maris, Kelsey
name: Massa, Gilda
name: Meynaerts, Erika
name: Pappa, Stavroula
name: Schwarz, Lucas
name: Vima Venerucci
name: Zučika, Aija
Publisher: name: Zenodo
Year: 2022
Subjects: Renewable energy communities
Stakeholder consultation
EU
Energy transition

description: This Deliverable 3.4 aims to elicit stakeholders’ experience and perspectives concerning renewable energy communities (RECs), to identify solutions to improve legal and policy frameworks and provide enabling conditions for RECs development, and opportunities and limitations for cross-country knowledge transfer. Building on the in-depth and qualitative study on how relevant actors perceive drivers and barriers to establish and successfully run RECs in Deliverable 2.3 - Synthesis Report on case-studies of drivers and barriers in five selected target regions (Standal et al. 2022), this Deliverable explores national and target region stakeholders’ views on attitudes, motivations, relevant technologies and legal forms, promising sectors for RECs, main barriers for developing RECs. Furthermore, the stakeholders’ familiarity with REDII and REC as a concept is explored, as well as national and local policies and support mechanisms that are seen as relevant for cross-country/region transfer.
(1784) Mary Charlotte Blakiston-Houston
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
DNA Repair Excision Nuclease Attacks Undamaged DNA: A POTENTIAL SOURCE OF SPONTANEOUS MUTATIONS
Creators: name: Branum, Mark E.
name: Sancar, Aziz
name: Reardon, Joyce T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: Nucleotide excision repair is a general repair system that eliminates many dissimilar lesions from DNA. In an effort to understand substrate determinants of this repair system, we tested DNAs with minor backbone modifications using the ultrasensitive excision assay. We found that a phosphorothioate and a methylphosphonate were excised with low efficiency. Surprisingly, we also found that fragments of 23-28 nucleotides and of 12-13 nucleotides characteristic of human and Escherichia coli excision repair, respectively, were removed from undamaged DNA at a significant rate. Considering the relative abundance of undamaged DNA in comparison to damaged DNA in the course of the life of an organism, we conclude that, in general, excision from and resynthesis of undamaged DNA may exceed the excision and resynthesis caused by DNA damage. As resynthesis is invariably associated with mutations, we propose that gratuitous repair may be an important source of spontaneous mutations.
Transport of Sputtered Particles in Capacitive Sputter Sources
Creators: name: Trieschmann, Jan
name: Mussenbrock, Thomas
Publisher: name: arXiv
Year: 2015
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: The transport of sputtered aluminum inside a multi frequency capacitively coupled plasma chamber is simulated by means of a kinetic test multi-particle approach. A novel consistent set of scattering parameters obtained for a modified variable hard sphere collision model is presented for both argon and aluminum. An angular dependent Thompson energy distribution is fitted to results from Monte Carlo simulations and used for the kinetic simulation of the transport of sputtered aluminum. For the proposed configuration the transport of sputtered particles is characterized under typical process conditions at a gas pressure of p=0.5 Pa. It is found that -- due to the peculiar geometric conditions -- the transport can be understood in a one dimensional picture, governed by the interaction of the imposed and backscattered particle fluxes. It is shown that the precise geometric features play an important role only in proximity to the electrode edges, where the effect of backscattering from the outside chamber volume becomes the governing mechanism.
(1786) Mary Gertrude Streatfeild
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(1787) Richard Bayly Blakiston-Houston
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Cavity-Enhanced Two-Photon Interference using Remote Quantum Dot Sources
Creators: name: Giesz, V.
name: Portalupi, S. L.
name: Grange, T.
name: Antón, C.
name: De Santis, L.
name: Demory, J.
name: Somaschi, N.
name: Sagnes, I.
name: Lemaître, A.
name: Lanco, L.
name: Auffeves, A.
name: Senellart, P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Optics (physics.optics)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum dots in cavities have been shown to be very bright sources of indistinguishable single photons. Yet the quantum interference between two bright quantum dot sources, a critical step for photon based quantum computation, has never been investigated. Here we report on such a measurement, taking advantage of a deterministic fabrication of the devices. We show that cavity quantum electrodynamics can efficiently improve the quantum interference between remote quantum dot sources: poorly indistinguishable photons can still interfere with good contrast with high quality photons emitted by a source in the strong Purcell regime. Our measurements and calculations show that cavity quantum electrodynamics is a powerful tool for interconnecting several devices.
description: 5 pages, 4 figures (Supp. Mat. attached)
(1788) Mary Isabella Houston
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.