Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine
Creators: name: Wilhelmsen, Kirk
name: Plon, Sharon E.
name: Deardorff, Matthew A.
name: Conlin, Laura K.
name: Appelbaum, Paul S.
name: Berg, Jonathan S.
name: Davis, James V.
name: Ho, Carolyn Y.
name: Vetter, Victoria L.
name: Gornick, Michele C.
name: Biesecker, Leslie G.
name: Jarvik, Gail P.
name: Raskind, Wendy H.
name: Yang, Yaping
name: Blout, Carrie L.
name: Manolio, Teri A.
name: Goddard, Katrina A.B.
name: Punj, Sumit
name: Masino, Aaron
name: Cooper, Greg M.
name: Oliver, Nelly M.
name: Machini, Kalotina
name: Robinson, Dan
name: Burt, Amber A.
name: Vassy, Jason L.
name: Roberts, J. Scott
name: Amaral, Michelle
name: Ghrundmeier, Bob
name: Janne, Pasi A.
name: Wilhelmsen, Kirk C.
name: Rehm, Heidi L.
name: Perry, Denise L.
name: Fullerton, Stephanie M.
name: Tsai, Ellen
name: Tarczy-Hornoch, Peter
name: Gray, David E.
name: Joffe, Steven
name: Evans, Barbara
name: McEwen, Jean
name: Devkota, Batsal
name: Scarano, Maria I.
name: Arora, Shubhangi
name: Lewis, Katie
name: Lebo, Matthew S.
name: Rivera-Munoz, Edgar A.
name: Richards, Carolyn Sue
name: Johnston, Jennifer
name: Lynch, Frances
name: Werner-Lin, Allison
name: Veenstra, David L.
name: Patrick, Donald L.
name: Kelley, Whitley
name: Koenig, Barbara A.
name: Kaufman, Dave
name: Lambert, Michele P.
name: Mody, Rajen
name: Dulik, Matthew C.
name: Karavite, Dean
name: Porter, Katie
name: Han, Paul
name: Clayton, Ellen W.
name: Grady, William M.
name: Sharp, Richard R.
name: Rini, Christine
name: Le, Lan Q.
name: Vats, Pankaj
name: Filipski, Kelly
name: Finnila, Candice R.
name: Young, Carol
name: Skinner, Debra
name: Martinez, Josue N.
name: Kirby, Christine
name: Feuerman, Lindsay Z.
name: Mooney, Sean D.
name: Caga-Anan, Charlisse F.
name: Evans, James P.
name: Powell, Bradford C.
name: Taber, Jennifer
name: Brown, Brian L.
name: Murray, Michael
name: Bernhardt, Barbara A.
name: Fishler, Kristen
name: McMullen, Carmit
name: East, Kelly
name: Amendola, Laura M.
name: Wolf, Susan M.
name: Stoffel, Elena
name: Azzariti, Danielle R.
name: Greenwood, Robert S.
name: Garraway, Levi A.
name: Knoppers, Bartha M.
name: Reigar, Dean A.
name: Green, Robert C.
name: Robinson, Marguerite E.
name: Kaufman, David
name: Parsons, Will
name: Hong, Celine
name: Scollon, Sarah
name: Marchuk, Daniel S.
name: Chung, Wendy K.
name: Sholl, Lynette M.
name: Yu, Joon-Ho
name: Girnary, Zahra S.
name: Lamb, Neil E.
name: Lee, Alexander
name: Ng, David
name: Davis, Kelly
name: Bebin, 
name: Gordon, Adam S.
name: Dorschner, Michael O.
name: Hutter, Carolyn M.
name: Christensen, Kurt D.
name: Henderson, Gail E.
name: Trinidad, Susan
name: Rich, Carla A.
name: Diamond, Pamela
name: Lee, Kaitlyn B.
name: Gonsalves, Steven
name: Hull, Sara
name: Hisama, Fuki M.
name: Aronson, Samuel J.
name: Kong, Sek Won
name: Hindorff, Lucia A.
name: Shirts, Brian
name: Gilmore, Marian J.
name: Carlson, Sara J.
name: Walser, Sarah A.
name: Spinner, Nancy B.
name: Biesecker, Barbara B.
name: Shirts, Brian H.
name: Jamal, Seema
name: Ou, Jeffrey
name: Wynn, Julia
name: Chahin, Nizar
name: Kauffman, Tia L.
name: Gutierrez, Amanda M.
name: Tabor, Holly K.
name: Siddiqui, Javed
name: Tomlinson, Ashley
name: Klein, William
name: Roberts, Scott
name: Horike-Pyne, Martha J.
name: Byers, Peter H.
name: Fan, Zheng
name: Parsons, Donald W.
name: Mieczkowski, Piotr A.
name: Moore, Elizabeth G.
name: Myers, Richard M.
name: Lennon, Niall
name: Holm, Ingrid A.
name: Miller, Jeff
name: Silverman, Elian
name: Kim, Jerry H.
name: Morris, Elissa
name: Cooper, Gregory M.
name: East, Kelly M.
name: Seifert, Bryce A.
name: Burke, Wylie
name: Calikoglu, Muge G.
name: Strande, Natasha T.
name: Lupo, Philip J.
name: Lonigro, Bob
name: Walsh, Rebecca C.
name: Whittle, Jana
name: Muzny, Donna
name: Crosslin, David R.
name: Pennington, Jeffrey
name: Giles, Karen
name: Cirino, Allison L.
name: Hoffman-Andrews, Lily B.
name: Gray, Stacy W.
name: Chinnaiyan, Arul M.
name: Nickerson, Deborah A.
name: Raesz-Martinez, Robin A.
name: Hart, Ragan
name: Dugan, Noreen P.
name: Heagerty, Patrick
name: Macrae, Calum
name: Leppig, Kathleen A.
name: Roche, Myra I.
name: Rodriguez, Laura Lyman
name: Van Allen, Eliezer M.
name: Brothers, Kyle B.
name: Himes, Patricia
name: Breitkopf, Carmen Radecki
name: De Vries, Raymond
name: Rosenthal, Elisabeth A.
name: Sybert, Virginia P.
name: Lockhart, Nicole
name: Exe, Nicole
name: Krantz, Ian D.
name: Simmons, Shirley
name: Biswas, Sawona
name: Simons, Janae V.
name: Lewis, Michelle Huckaby
name: Romasko, Edward J.
name: Garrett, Jeremy R.
name: Lindeman, Neal I.
name: Sunyaev, Shamil
name: Krier, Joel B.
name: Seidman, Christine E.
name: Hiatt, Susan M.
name: Bowling, Kevin M.
name: Leo, Michael C.
name: Robinson, Jill O.
name: Salama, Joseph S.
name: Wilfond, Benjamin S.
name: Barsh, Greg S.
name: Reiss, Jacob A.
name: Tilley, Christine R.
name: Zikmund-Fisher, Brian J
name: McGuire, Amy
name: Miller, Victoria A.
name: Taylor, Deanne M.
name: Jensen, Brian C.
name: McCullough, Laurence
name: Dukhovny, Dmitry
name: Weck, Karen
name: Everett, Jessica
name: Robertson, Peggy D.
name: Schneider, Jennifer
name: Vries, Raymond D.
name: Petersen, Gloria M.
name: Wagle, Nikhil
name: McLaughlin, Heather M.
name: Lose, Edward J.
name: Hensman, Naomi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Despite rapid technical progress and demonstrable effectiveness for some types of diagnosis and therapy, much remains to be learned about clinical genome and exome sequencing (CGES) and its role within the practice of medicine. The Clinical Sequencing Exploratory Research (CSER) consortium includes 18 extramural research projects, one National Human Genome Research Institute (NHGRI) intramural project, and a coordinating center funded by the NHGRI and National Cancer Institute. The consortium is exploring analytic and clinical validity and utility, as well as the ethical, legal, and social implications of sequencing via multidisciplinary approaches; it has thus far recruited 5,577 participants across a spectrum of symptomatic and healthy children and adults by utilizing both germline and cancer sequencing. The CSER consortium is analyzing data and creating publically available procedures and tools related to participant preferences and consent, variant classification, disclosure and management of primary and secondary findings, health outcomes, and integration with electronic health records. Future research directions will refine measures of clinical utility of CGES in both germline and somatic testing, evaluate the use of CGES for screening in healthy individuals, explore the penetrance of pathogenic variants through extensive phenotyping, reduce discordances in public databases of genes and variants, examine social and ethnic disparities in the provision of genomics services, explore regulatory issues, and estimate the value and downstream costs of sequencing. The CSER consortium has established a shared community of research sites by using diverse approaches to pursue the evidence-based development of best practices in genomic medicine.