cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Non cell-Autonomous activity of the hemidesmosomal protein bp180/collagen xvii in granulopoiesis in humanized nc16a mice
Creators: name: Vilen, B.
name: Li, N.
name: Hwang, B.-J.
name: Liu, Z.
name: Thomas, N.E.
name: Lin, L.
name: Diaz, L.A.
name: Googe, P.
name: Miao, E.
name: Ting, J.
Publisher: name: American Association of Immunologists
Year: 2020

description: BP180 (also termed type XVII collagen) is a hemidesmosomal protein and plays a critical role in cell cell matrix adhesion in the skin; however, its other biological functions are largely unclear. In this study, we generated a BP180 functional deficient mouse strain by deleting its extracellular domain of humanized NC16A (termed DNC16A mice). We found that BP180 is expressed by bone marrow mesenchymal stem cells (BM-MSC), and its functional deficiency leads to myeloid hyperplasia. Altered granulopoiesis in DNC16A mice is through bone marrow stromal cells evidenced by bone marrow transplantation. Furthermore, the level of G-CSF in bone marrow and circulation were significantly increased in DNC16A mice as compared with wild-Type mice. The increased G-CSF was accompanied by an increased activation of the NF-kB signaling pathway in bone marrow and BM-MSC of DNC16A mice. Blockade of G-CSF restored normal granulopoiesis in DNC16A mice. Inhibition of NF-kB signaling pathway significantly reduces the release of G-CSF from DNC16A BM-MSC in vitro and the level of serum G-CSF in DNC16A mice. To our knowledge, these findings provide the first direct evidence that BP180 plays an important role in granulopoiesis through regulating NF-kB signaling pathway in BM-MSC.
Nanopharmaceutical for improved anti-HIV therapy
Creators: name: Wan, Li
Publisher: name: No Publisher Supplied
Year: 2007

description: Curing HIV-1 infection has remained elusive due to low and fluctuating drug levels, arising from poor absorption, viral reservoirs and sanctuary sites, toxicity and patient non-adherence. The theme of the current study is to investigate the value of combining AIDS drugs and modifiers of cellular uptake into macromolecular nanocarriers having novel pharmacological properties for improving current anti-HIV therapy. Nanopharmaceuticals were prepared from different combinations of saquinavir (SQV), R.I.CK-Tat9 and the polymeric nanocarrier polyethylene glycol. Anti-HIV activities were measured in MT-2 cells while parallel studies were performed in uninfected cells to determine cellular toxicity. Flow cytometry and confocal microscopy studies suggested that variations in intracellular uptake and intracellular localization, as well as synergistic inhibitory effects of SQV and Tat peptides, contributed to the unexpected and substantial differences in antiviral activity. Our results demonstrate that highly potent multi-drug nanopharmaceuticals with low non-specific toxicity can be produced by combining moieties with anti-HIV agents for different targets onto macromolecules having improved delivery properties.The present study also addressed the issue of insufficient drug exposure of viral reservoirs in macrophages. Macrophages are a key target and primary cellular reservoir for HIV, and are believed to be responsible for the viral rebound effect observed upon the discontinuation of therapy. In this study, multiple copies of N-formyl-Met-Leu-Phe (fMLF), a known chemo-attractant for macrophages, were conjugated to multifunctional nanocarrier derived from commercially available or novel peptide-based PEGs. The results of uptake studies indicated that appending only two copies of fMLF to the nanocarrier is sufficient for optimal binding and the optimal size of the nanocarrier was about 20 kDa. Further pharmacokinetics and biodistribution studies demonstrated that the attachment of fMLF increased accumulation of PEG nanocarriers in major macrophage-residing tissues such as liver, kidneys and spleen. Taken together, these results demonstrated the feasibility of using macrophage-targeted nanocarriers for enhancing drug uptake in human macrophage-like cells in vitro or macrophages residing in tissues in vivo. These results indicate great promise for enhancing targeted drug delivery to HIV-infected macrophages, which may eventually improve current anti-HIV therapy by improving therapeutic efficacy, minimizing systemic toxicity and simplifying administration regimens.
Fully fluorinated non-carbon compounds NF3 and SF6 as ideal technosignature gases
Creators: name: Seager, Sara
name: Petkowski, Janusz J.
name: Huang, Jingcheng
name: Zhan, Zhuchang
name: Ravela, Sai
name: Bains, William
Publisher: name: arXiv
Year: 2023
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Waste gas products from technological civilizations may accumulate in an exoplanet atmosphere to detectable levels. We propose nitrogen trifluoride (NF3) and sulfur hexafluoride (SF6) as ideal technosignature gases. Earth life avoids producing or using any N-F or S-F bond-containing molecules and makes no fully fluorinated molecules with any element. NF3 and SF6 may be universal technosignatures owing to their special industrial properties, which unlike biosignature gases, are not species-dependent. Other key relevant qualities of NF3 and SF6 are: their extremely low water solubility, unique spectral features, and long atmospheric lifetimes. NF3 has no non-human sources and was absent from Earth's pre-industrial atmosphere. SF6 is released in only tiny amounts from fluorine-containing minerals, and is likely produced in only trivial amounts by volcanic eruptions. We propose a strategy to rule out SF6's abiotic source by simultaneous observations of SiF4, which is released by volcanoes in an order of magnitude higher abundance than SF6. Other fully fluorinated human-made molecules are of interest, but their chemical and spectral properties are unavailable. We summarize why life on Earth-and perhaps life elsewhere-avoids using F. We caution, however, that we cannot definitively disentangle an alien biochemistry byproduct from a technosignature gas.
description: Published as a part of the special collection "Exoplanets" in Scientific Reports
An innovative architecture for multi-mission Flight Dynamics and satellite programming software
Creators: name:  J. ANXIONNAT
name:   V. MAURUSSANE
Publisher: name: Proceedings of  the 9th European Conference for Aerospace Sciences. Lille, France, 27 June - 1 July, 2022
Year: 2022
Subjects: FLIGHT DYNAMICS
GNC
AVIONICS

description: A Flight Dynamics Software (FDS), which is part of a Ground Control Segment for a space system, includes applications used to generate and provide all the data for satellite programming and to predict its attitude. The CNES SIRIUS in-house project team designs and develops FDS for several missions. For that reason, it aims at building an architecture that can be reused for all of them. One of the applications addresses the attitude guidance definition and programming thematic domain. The two main objectives for that domain are the following: Compute and provide the data interface named functional requests, which contains all the information needed to produce the telecommands to be sent to the satellite. Maintain a prediction of the future spacecraft attitude, either commanded from ground or eventually generated onboard by autonomous capabilities. A versatile architecture How to succeed in creating a basic versatile architecture which can deal with all specificities related to every given satellite? In other words, how to manage to produce functional requests with different definition from one satellite to another, and how to take into account variable use cases from programming requirements of all possible missions? In this paper, we will present and discuss our solutions to meet those issues. We will go through these two meta points of view and we will detail the two main sets of requirements: first, the mission requirements, i.e. the use cases, and second, the interface requirements, i.e. the functional requests. The first set may be seen as an upstream or global need, and the second one as a downstream one. A key point of our architecture is the separation between generic and specific parts of the algorithmic components. A partitioned architecture We will see that the architecture finally designed defines several applications whose roles are well partitioned and interfaces match in a sequence. The successive steps are: to handle an input instruction and prepare programming activities, to compute the functional requests, to check them before providing. Separate these roles allows the different types of requirements to be addressed by different and independent components. The objective is then to succeed in designing a well-defined interface between them from one to another. Data structure The internal data our applications rely on consists of a scenario, which is a complex data structure containing a set of timelines (called feeds), each one being dedicated to a precise thematic function (attitude, trajectory, ). In that scenario, a particular subset of feeds called the programming plan is the consistent container of the process-in-progress data. We will detail the usage of this programming plan and review its building process along the applications chain.
Selected methods and potential applications in Learning Sites
Creators: name: Coll, M
name: Lynam, C
name: Piet, G
name: Carstensen, J
name: Hemraj, D
name: Borja, A
name: Chust, G
name: Claudet, J
name: Evcen, A
name: Espasandin, L
name: Fortibuoni, T
name: Gamze, L
name: Garces, E
name: Loiseau, C
name: Olano, A
name: Ortega, M
name: Pouso, S
name: Salinas-Akhmadeeva, I
name: Stamatiadou, V
name: Tamis, J
name: Tan, I
name: Uyarra, M C
name: Villarino, V
Publisher: name: Zenodo
Year: 2024

description: Deliverable 3.1
Particle-based Fast Jet Simulation at the LHC with Variational Autoencoders
Creators: name: Touranakou, Mary
name: Chernyavskaya, Nadezda
name: Duarte, Javier
name: Gunopulos, Dimitrios
name: Kansal, Raghav
name: Orzari, Breno
name: Pierini, Maurizio
name: Tomei, Thiago
name: Vlimant, Jean-Roch
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computational Physics (physics.comp-ph)
subject: Machine Learning (cs.LG)
subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: We study how to use Deep Variational Autoencoders for a fast simulation of jets of particles at the LHC. We represent jets as a list of constituents, characterized by their momenta. Starting from a simulation of the jet before detector effects, we train a Deep Variational Autoencoder to return the corresponding list of constituents after detection. Doing so, we bypass both the time-consuming detector simulation and the collision reconstruction steps of a traditional processing chain, speeding up significantly the events generation workflow. Through model optimization and hyperparameter tuning, we achieve state-of-the-art precision on the jet four-momentum, while providing an accurate description of the constituents momenta, and an inference time comparable to that of a rule-based fast simulation.
description: 11 pages, 8 figures
TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination
Creators: name: Davis, B.K.
name: Tam, J.W.
name: Conti, B.J.
name: Liang, K.
name: Wang, L.
name: Zhang, Y.
name: Ting, J.P.-Y.
name: Sun, S.
name: Li, S.
name: Deng, M.
name: Luo, X.
name: Brickey, W.J.
name: Guo, H.
name: Ko, C.-C.
name: Lei, Y.L.
name: Zhang, L.
name: Petrucelli, A.
Publisher: name: Nature Research
Year: 2020

description: Innate immunity to nucleic acids forms the backbone for anti-viral immunity and several inflammatory diseases. Upon sensing cytosolic viral RNA, retinoic acid-inducible gene-I-like receptors (RLRs) interact with the mitochondrial antiviral signaling protein (MAVS) and activate TANK-binding kinase 1 (TBK1) to induce type I interferon (IFN-I). TRAF3-interacting protein 3 (TRAF3IP3, T3JAM) is essential for T and B cell development. It is also well-expressed by myeloid cells, where its role is unknown. Here we report that TRAF3IP3 suppresses cytosolic poly(I:C), 5’ppp-dsRNA, and vesicular stomatitis virus (VSV) triggers IFN-I expression in overexpression systems and Traf3ip3−/− primary myeloid cells. The mechanism of action is through the interaction of TRAF3IP3 with endogenous TRAF3 and TBK1. This leads to the degradative K48 ubiquitination of TBK1 via its K372 residue in a DTX4-dependent fashion. Mice with myeloid-specific gene deletion of Traf3ip3 have increased RNA virus-triggered IFN-I production and reduced susceptibility to virus. These results identify a function of TRAF3IP3 in the regulation of the host response to cytosolic viral RNA in myeloid cells.
Transfer Learning for Data Stream Mining in Non-Stationary Environments
Creators: name: Du, Honghui
Publisher: name: University of Leicester
Year: 2022
Subjects: Uncategorized

description: The relationship between the input and output data changes over time refer to as concept drift, which is a major problem in online learning due to its impact on the predictive performance of data stream mining systems. Typically, learning models cannot be well trained until sufficient data representing the new concept have been collected. Transferring the knowledge learnt from different sources to accelerate the learning process of the new target concept and to improve the predictive performance is a feasible direction. This thesis concentrates on how to use transfer learning to improve the predictive performance in non-stationary environments (e.g., learning concept drifts). The main contributions of this thesis consist of: • The first approach is able to transfer the knowledge between multiple data streaming sources in non-stationary environments. This approach is called Multi-sourcE onLine TrAnsfer learning for Non-statIonary Environments (Melanie). • The first approach is able to transfer the knowledge between multiple data sources even when source and target concepts do not match in nonstationary environments. This approach is called Multi-source mApping with tRansfer LearnIng for Non-stationary Environments (MARLINE). • The first two approaches are able to transfer the knowledge from different labels and label dependencies between multi-sources in nonstationary environments. These two approaches are called Binary Relevance Multi-Label classi?cation in non-stAtionary enviRonments with muLti-SourcE traNsfer lEarning (BR-MARLENE) and Binary Relevance PairWise Multi-Label classi?cation in non-stAtionary enviRonments with muLti-SourcE traNsfer lEarning (BRPW-MARLENE). • We launch comprehensive evaluations on the proposed methods against different methods with different datasets to have a better understanding of what contents, when and how transfer learning can help learning models to improve the performance in non-stationary environments.
D3.1 Protocol for data requirements for modelling and DSS tool
Creators: name: Birk, Morten
Publisher: name: Zenodo
Year: 2023

description: This document describes the protocol for the dataflow used in trans4num task 3.1 ’Monitoring of nutrient flows based on (remote) sensing in case regions’, in order to ensure effective and useful collection and distribution of remote sensing data between partners, a common understanding of needs and requirements of the remote sensing data for task 3.2 ‘Develop a Decision Support System (including a nutrient management plan) for optimum nutrient supply at farm, regional and watershed level’
The distribution of neutral hydrogen around high-redshift galaxies and quasars in the EAGLE simulation
Creators: name: Rahmati, Alireza
name: Schaye, Joop
name: Bower, Richard G.
name: Crain, Robert A.
name: Furlong, Michelle
name: Schaller, Matthieu
name: Theuns, Tom
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The observed high covering fractions of neutral hydrogen (HI) with column densities above $\sim 10^{17} \rm{cm}^{-2}$ around Lyman-Break Galaxies (LBGs) and bright quasars at redshifts z ~ 2-3 has been identified as a challenge for simulations of galaxy formation. We use the EAGLE cosmological, hydrodynamical simulation, which has been shown to reproduce a wide range of galaxy properties and for which the subgrid feedback was calibrated without considering gas properties, to study the distribution of HI around high-redshift galaxies. We predict the covering fractions of strong HI absorbers ($N_{\rm{HI}} \gtrsim 10^{17} \rm{cm}^{-2}$) inside haloes to increase rapidly with redshift but to depend only weakly on halo mass. For massive ($M_{200} \gtrsim 10^{12} {\rm M_{\odot}}$) halos the covering fraction profiles are nearly scale-invariant and we provide fitting functions that reproduce the simulation results. While efficient feedback is required to increase the HI covering fractions to the high observed values, the distribution of strong absorbers in and around halos of a fixed mass is insensitive to factor of two variations in the strength of the stellar feedback. In contrast, at fixed stellar mass the predicted HI distribution is highly sensitive to the feedback efficiency. The fiducial EAGLE simulation reproduces both the observed global column density distribution function of HI and the observed radial covering fraction profiles of strong HI absorbers around LBGs and bright quasars.
description: Accepted for publication in MNRAS. V2: Very minor changes
Open Access for researchers: mandates, recommendations, strengths... What should you know?
Creators: name: Sanchez, Alicia Fatima Gomez
name: Maseda, Irene
Publisher: name: Zenodo
Year: 2020
Subjects: Open Access
Publications
Scientific Research

description: The Open Access movement was born in the late 90s with the idea of promoting free access to scientific literature, so that researchers and academics can share their knowledge and keep the copyright of their own publications. Although in some fields OA movement has been very successful, in others, traditional publishing is still the standard. Over time, research funding agencies begun to adopt policies to ensure that research outcomes return to the researchers’ community and developed mandates to oblige researchers to make their publications freely accessible. To achieve this it becomes necessary for researchers to know some aspects to know some issues about OA both, before and after publication. There are two ways autos can provide OA: by publishing in OA journals or in regular journals with OA options (Golden Open Access) or by archiving their works by themselves or by librarians or administrators (Green Open Access). With the first option articles are freely available immediately upon publication, but authors have to pay a fee and sometimes could be expensive. The second option implies no additional charges but requires an extra effort, time and also knowledge in order to archive the documents (find the right repository, publishers’ copyright policies, embargo periods…). In this context, the CNIC Library and Information Service has developed an assessment program, in order to support the researchers to fulfill the funding bodies mandate requirements.
title: Multidimensional Library for the Improved Identification of Per- and Polyfluoroalkyl Substances (PFAS)
Creators: name: Kara M. Joseph
name: Anna K. Boatman
name: James N. Dodds
name: Kaylie I. Kirkwood-Donelson
name: Jack P. Ryan
name: Jian Zhang
name: Paul A. Thiessen
name: Evan E. Bolton
name: Alan Valdiviezo
name: Yelena Sapozhnikova
name: Ivan Rusyn
name: Emma Schymanski
name: Erin S. Baker
Publisher: name: LCSB
Year: 2024

description: As the occurrence of human diseases and conditions increase, questions continue to arise about their linkages to chemical exposure, especially for per-and polyfluoroalkyl substances (PFAS). Currently, many chemicals of concern have limited experimentalinformation available for their use in analytical assessments. Here, we aim to increase this knowledge by providing the scientific community with multidimensional characteristics for 174 PFAS and their resulting 280 ion types. Using a platform coupling reversed-phase liquid chromatography (RPLC), electrospray ionization (ESI) or atmospheric pressure chemical onization (APCI), drift tube ion mobility spectrometry (IMS), and mass spectrometry (MS), the retention times, collision cross section (CCS) values, and m/z ratios were determined for all analytes and assembled into an openly available multidimensional database. This information will provide the scientific community with essential characteristics to expand analytical assessments of PFAS and improve machine learning capabilities for discovering new PFAS. Additionally, all CCS values have been added to PubChem and the multidimensional database webpage (https://tarheels.live/bakerlab/databases) and Zenodo (10.5281/zenodo.13387493) and populated regularly as new PFAS standards become available.
Transformations of Stabilizer States in Quantum Networks
Creators: name: Englbrecht, Matthias
name: Kraft, Tristan
name: Kraus, Barbara
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Stabilizer states and graph states find application in quantum error correction, measurement-based quantum computation and various other concepts in quantum information theory. In this work, we study party-local Clifford (PLC) transformations among stabilizer states. These transformations arise as a physically motivated extension of local operations in quantum networks with access to bipartite entanglement between some of the nodes of the network. First, we show that PLC transformations among graph states are equivalent to a generalization of the well-known local complementation, which describes local Clifford transformations among graph states. Then, we introduce a mathematical framework to study PLC equivalence of stabilizer states, relating it to the classification of tuples of bilinear forms. This framework allows us to study decompositions of stabilizer states into tensor products of indecomposable ones, that is, decompositions into states from the entanglement generating set (EGS). While the EGS is finite up to $3$ parties [Bravyi et al., J. Math. Phys. {\bf 47}, 062106~(2006)], we show that for $4$ and more parties it is an infinite set, even when considering party-local unitary transformations. Moreover, we explicitly compute the EGS for $4$ parties up to $10$ qubits. Finally, we generalize the framework to qudit stabilizer states in prime dimensions not equal to $2$, which allows us to show that the decomposition of qudit stabilizer states into states from the EGS is unique.
description: 37 pages, 7 figures, final version
The Three Dimensional Evolution to Core Collapse of a Massive Star
Creators: name: Couch, Sean M.
name: Chatzopoulos, Emmanouil
name: Arnett, W. David
name: Timmes, F. X.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present the first three dimensional (3D) simulation of the final minutes of iron core growth in a massive star, up to and including the point of core gravitational instability and collapse. We self-consistently capture the development of strong convection driven by violent Si burning in the shell surrounding the iron core. This convective burning builds the iron core to its critical (Chandrasekhar) mass and collapse ensues, driven by electron capture and photodisintegration. The non-spherical structure and motion (turbulent fluctuations) generated by 3D convection is substantial at the point of collapse. We examine the impact of such physically-realistic 3D initial conditions on the core-collapse supernova mechanism using 3D simulations including multispecies neutrino leakage. We conclude that non-spherical progenitor structure should not be ignored, and has a significant and favorable impact on the likelihood for neutrino-driven explosions.
description: 7 pages, 5 figures, accepted for publication in ApJ Letters. Movies may be viewed at http://flash.uchicago.edu/~smc/progen3d
Mental Health Literacy: Conceptualisation, Measurement, and the Relationship within wider student mental health.
Creators: name: Joshi, Radhika
Publisher: name: University of Leicester
Year: 2022
Subjects: Uncategorized

description: This thesis proposes a new measure of mental health literacy specifically for use among university students by developing items relevant to university experiences and testing the usefulness of this measure within wider student mental health research. To do this, four studies were conducted using various methods such as longitudinal and experimental design. Participants included university students who completed measures of mental health literacy, help-seeking intentions, internal stigma, personality, and mental health. The first study was split into two parts; the first part sought to develop the Student Mental Health Literacy Scale items. The second part tested the factor structure and confirmed that mental health literacy is multidimensional comprised of six unique factors. Using the new Student Mental Health Literacy Scale, study Two explored the relationship between mental health literacy and help-seeking intentions. Study Three was a longitudinal study that assessed whether mental health literacy predicted mental health outcomes (depression and anxiety) over time. The final study evaluated whether individual differences such as personality accounted for unique variance in mental health literacy levels in university students. Overall, the results suggest that the concept and new measurement of mental health literacy are useful in furthering our understanding of mental health outcomes and help to increase the specificity of existing relationships, specifically within university students.
Novel counterexample to the Nelson-Seiberg theorem
Creators: name: Brister, James
name: Sun, Zheng
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We present a new type of counterexample to the Nelson-Seiberg theorem. It is a generic R-symmetric Wess-Zumino model with nine chiral superfields, including one field of R-charge 2 and no R-charge 0 field. As in previous counterexamples, the model gives a set of degenerate supersymmetric vacua with a non-zero expectation value for a pair of oppositely R-charged fields. However, one of these fields appears quadratically in the superpotential, and many other fields with non-zero R-charges gain non-zero expectation values at the vacuum, and so this model escapes the sufficient condition for counterexamples established in previous literature. Thus there are still open problems in the relation of R-symmetries to supersymmetry breaking in generic models.
description: 7 pages; v2: discussion on the full vacuum structure, saddles and nonexistence of non-SUSY vacua or runaways; v3: typos, Phys.Rev.D pre-publication version
raw data 15 herg blocking drugs march 2022
Creators: name: champeroux, pascal
Publisher: name: figshare
Year: 2022
Subjects: subject: 111501 Basic Pharmacology
subject: FOS: Clinical medicine
subject: 110901 Autonomic Nervous System
subject: 110201 Cardiology (incl. Cardiovascular Diseases)

description: Effects of 15 torsadogenic hERG blocking drugs (astemizole, chlorpromazine, cisapride, droperidol, ibutilide, dofetilide, haloperidol, moxifloxacin, pimozide, quinidine, risperidone, sotalol, sertindole, terfenadine, thioridazine) were assessed by telemetry in beagle dogs. Hemodynamic effects on diastolic and systolic arterial pressure were analysed from the first doses causing QTc prolongation and/or HFQT oscillations enhancement. Autonomic control changes were analysed with the High Frequency Autonomic Modulation (HFAM) model.
TASAVVUFIY TA'LIMNING MA'NAVIY TARBIYADAGI O'RNI
Creators: name: Satimova, Sevinch
Publisher: name: Zenodo
Year: 2025

description: Mazkur ishda tasavvufda ma'naviy tarbiya metodologiyasi va uning pedagogik asoslari keng muhokama qilingan. Tasavvuf ma’naviyatini shakllantirishda individual va jamiyat darajasidagi ahamiyatga ega bo‘lgan pedagogik usullar va uslublar tahlil qilingan. Shuningdek, ma'naviy tarbiyaning maqsad va vazifalari, zamonaviy ta'lim tizimida tasavvuf tarbiyasi metodlarini qo‘llashning imkoniyatlari yoritilgan.
Amazonía patriota
Creators: name: Cardemil Krause, Cristóbal Felipe
Publisher: name: No Publisher Supplied
Year: 2013

description: This work discusses how national discourse on the Amazon in the early 20th century served as a façade to hide exploitation and horror in the area. This happened during the lucrative rubber boom, which forced Latin American governments to begin an aggressive expansion of the nation-state in the region. These changes generated competing national representations of an Amazon subjected to neocolonialist practices. I work with models of representation of the Amazon by Brazilian Euclides da Cunha and a number of Peruvians, among them Hildebrando Fuentes, Carlos Valcárcel, and Carlos Rey de Castro. Their opposing views reveal an Amazon that resists normalization and modernization, as well as the horror to which indigenous populations are subjected in this process. I approach this situation from postcolonial, spatial and nation-building perspectives, which relates my study to current topics of debate in Latin American scholarship, among them indigenous resistance or vindication movements, human rights demands, and historic memory. Thus, this project is built upon the intersection of literature and history, as well as comments on exploitation practices that have been common to Latin America at large.
A simple determination of the halo size $L$ from $^{10}$Be/$^9$Be data
Creators: name: Maurin, D.
name: Bueno, E. Ferronato
name: Derome, L.
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The AMS-02 and HELIX experiments should soon provide $\mathrm{^{10}Be/^9Be}$ cosmic-ray data of unprecedented precision. We propose an analytical formula to quickly and accurately determine $L$ from these data. Our formula is validated against the full calculation performed with the propagation code \usine{}. We compare the constraints on $L$ set by Be/B and $\mathrm{^{10}Be/^9Be}$, relying on updated sets of production cross-sections. The best-fit $L$ from AMS-02 Be/B data is shifted from 5 kpc to 3.8 kpc when using the updated cross-sections. We obtained consistent results from the Be/B analysis with USINE, $L=3.8^{+2.8}_{-1.6}$ kpc (data and cross-section uncertainties), and from the analysis of $\mathrm{^{10}Be/^9Be}$ data with the simplified formula, $L=4.7\pm0.6$ (data uncertainties) $\pm2$ (cross-section uncertainties) kpc. The analytical formula indicates that improvements on $L$ thanks to future data will be limited by production cross-section uncertainties, unless either $\mathrm{^{10}Be/^9Be}$ measurements are extended up to several tens of GeV/n, or nuclear data for the production of $\mathrm{^{10}Be}$ and $\mathrm{^9Be}$ are improved; new data for the production cross-section of $\mathrm{^{16}O}$ into Be isotopes above a few GeV/n are especially desired.
description: 9 pages, 2 tables, 5 figures (matches accepted A&A version): comparison to [De21] moved to appendix (also highlight impact of reacceleration)
Assessing lay theories of psychotherapy using the Q-sort method
Creators: name: Grinfeld Moses, Lisa
Publisher: name: No Publisher Supplied
Year: 2012

description: This study used the Q-sort method and qualitative interview to gather exploratory data on what potential psychotherapy clients think that therapists should be doing to best help their clients. While current literature suggests that clinical psychologists generally align themselves with either “psychodynamic/humanistic” or “CBT/scientific” views of psychotherapy, little is known regarding whether individuals seeking psychotherapy have similar views of the therapy process. Fifty-eight Q-sort statements addressing what psychotherapy should be like were created in consultation with clinical psychologists. Forty participants, twenty from the general population and twenty seeking therapy at a college counseling center, took part in the study. The procedure involved ranking Q-sort statements according to level of agreement and answering follow-up questions during an interview. Results indicated that participants did have worldviews, or “lay theories” of psychotherapy that corresponded to different approaches to conducting therapy. Factor analysis yielded two distinct groups of participants, with one group endorsing a more “unstructured” type of therapy in which open-ended reflection and exploration were considered important for therapy but having a formal diagnosis was not considered as crucial, and the other characterized by a more “structured” type of therapy in which formal diagnosis, goal setting and problem solving were considered more important. Other significant findings included an overall preference by all participants for therapy to be uniquely tailored to the individual client, for therapists to help the client talk about the past, and for therapists to focus on interpretation of clients’ communications.
Translating Violence in Dalit Women's Perspectives
Creators: name: Ankita Kilsan
Publisher: name: Zenodo
Year: 2022

description: The paper argues for the intersection of caste and gender, focusing on how Dalit women experience andarticulate violence in their lives. This study situates Dalit women's voices at the center, highlighting thenuanced ways in which they narrate their experiences of oppression. The paper employs a feministframework, recognizing that the violence faced by Dalit women is not only physical but also structural andsymbolic, embedded in social, cultural, and linguistic practices. Through an analysis of oral histories,autobiographies, and literary texts by Dalit women, the research explores how these narratives disruptdominant caste and gender discourses. By translating these experiences into a broader context, the paperargues that Dalit women's perspectives offer critical insights into the intersections of caste, gender, andviolence, challenging mainstream feminist and anti-caste movements to be more inclusive. This translationis both linguistic cultural and epistemological, aiming to bridge the gap between lived experiences andtheoretical frameworks. The study ultimately calls for a rethinking of feminist solidarity and anti-casteactivism that center the voices and agency of Dalit women
Zip file containing MLM_unpicked_SPA.html and MLM_unpicked.html: explanatory documents accompanying publication
Creators: name: Evans, Chris
Publisher: name: Zenodo
Year: 2022
Subjects: multi-level modelling
MLM
statistics
Practice Based Evidence (PBE)

description: These two files, one in Spanish and one in English which are supplementary material to the paper, accepted for Studies in Psychology (doi to follow here when paper published): Investigación Basada en la Práctica con Psicólogos en Formación: Presentación de un Modelo de Supervisión y Uso de la Monitorización Rutinaria de Resultados Practice-based Research with Psychologists-in-training: Presentation of a Model of Supervision and Use of Routine Outcome Monitoring It contains an explanation, aimed at practitioners, of the multi-level model used in the paper. The files are also available as: https://www.psyctc.org/stats/MLM_unpicked.html and https://www.psyctc.org/stats/MLM_unpicked_SPA.html
Reinforcement Learning Framework for Server Placement and Workload Allocation in Multi-Access Edge Computing
Creators: name: Mazloomi, Anahita
name: Sami, Hani
name: Bentahar, Jamal
name: Otrok, Hadi
name: Mourad, Azzam
Publisher: name: arXiv
Year: 2022
Subjects: subject: Artificial Intelligence (cs.AI)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Cloud computing is a reliable solution to provide distributed computation power. However, real-time response is still challenging regarding the enormous amount of data generated by the IoT devices in 5G and 6G networks. Thus, multi-access edge computing (MEC), which consists of distributing the edge servers in the proximity of end-users to have low latency besides the higher processing power, is increasingly becoming a vital factor for the success of modern applications. This paper addresses the problem of minimizing both, the network delay, which is the main objective of MEC, and the number of edge servers to provide a MEC design with minimum cost. This MEC design consists of edge servers placement and base stations allocation, which makes it a joint combinatorial optimization problem (COP). Recently, reinforcement learning (RL) has shown promising results for COPs. However, modeling real-world problems using RL when the state and action spaces are large still needs investigation. We propose a novel RL framework with an efficient representation and modeling of the state space, action space and the penalty function in the design of the underlying Markov Decision Process (MDP) for solving our problem.
The global response to the COVID-19 pandemic: how have immunology societies contributed?
Creators: name: Gazzinelli, R.T.
name: Mbengue, B.
name: Bortoluci, K.R.
name: Romano, M.
name: Perez, A.B.
name: Falk, C.
name: Lambrecht, B.N.
name: Annunziato, F.
name: Ariel, A.
name: Kiyono, H.
name: Chereshnev, V.
name: Osier, F.
name: Pérez, O.
name: Fraser, J.
name: Akbar, A.N.
name: Mbow, M.
name: Wu, Y.
name: Ting, J.P.Y.
name: Cassatella, M.A.
name: Evans, J.
name: Dieye, A.
name: Patel, K.D.
name: Zamboni, D.S.
name: Barda-Saad, M.
name: Brown, D.E.
name: Niang, M.D.S.
name: Suchard, M.
name: Kamradt, T.
name: Santoni, A.
Publisher: name: Nature Research
Year: 2020

description: The COVID-19 pandemic is shining a spotlight on the field of immunology like never before. To appreciate the diverse ways in which immunologists have contributed, Nature Reviews Immunology invited the president of the International Union of Immunological Societies and the presidents of 15 other national immunology societies to discuss how they and their members responded following the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Vitamin D insufficiency increases risk of chronic pain among African Americans experiencing motor vehicle collision
Creators: name: Beaudoin, F.L.
name: Ting, J.P.
name: Bortsov, A.
name: Linnstaedt, S.D.
name: McLean, S.A.
name: Hendry, P.L.
name: Velilla, M.-A.
name: Mauck, M.C.
name: Domeier, R.
name: Kurz, M.
name: Pearson, C.
name: Lewandowski, C.
name: Datner, E.
name: Fillingim, R.B.
Publisher: name: NLM (Medline)
Year: 2020

description: African Americans experience an increased burden of motor vehicle collision (MVC), post-MVC musculoskeletal pain, and vitamin D insufficiency. In this prospective multicenter study, we tested the hypothesis that African Americans (n = 133) presenting to the emergency department after MVC with low peritraumatic vitamin D levels would have worse chronic musculoskeletal pain outcomes compared to individuals with sufficient vitamin D. Vitamin D levels were assessed in the early aftermath of MVC through enzyme-linked immunosorbent assay, and pain severity was assessed using the 0 to 10 numeric rating scale at 6 weeks, 6 months, and 1 year. In repeated-measures analysis, African American MVC survivors with vitamin D insufficiency experienced more severe chronic pain (β = 1.18, P = 0.031). In secondary analyses, we assessed for evidence that the effect of vitamin D on post-MVC pain outcomes is mediated, at least in part, by the influence of vitamin D on genetic variants in genes involved in immune system regulation (IL-10 and NLRP3). Genotyping was performed using a genome-wide microarray using collected DNA samples. Secondary analyses suggest that the effect of vitamin D on post-MVC pain outcomes may be influenced by genetic variation in IL-10 and NLRP3. Further studies are needed to assess the impact of vitamin D insufficiency on pain outcomes in African Americans experiencing MVC and other common trauma exposures, to assess factors affecting this relationship, and to assess the efficacy of administering vitamin D in the immediate aftermath of MVC to prevent chronic pain. Such low-cost, nonopioid interventions are urgently needed to address chronic pain development after MVC.
Observational constraints on the interacting dark energy - dark matter (IDM) cosmological models
Creators: name: Harko, T.
name: Asadi, K.
name: Moshafi, H.
name: Sheikhahmadi, H.
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Particle creation (or annihilation) mechanisms, described by either quantum field theoretical models, or by the thermodynamics of irreversible processes, play an important role in the evolution of the early Universe, like, for example, in the warm inflationary scenario. Following a similar approach, based on the thermodynamics of open systems, in the present work we investigate the consequences of the interaction, decay, and particle generation in a many-component Universe, containing dark energy, dark matter, radiation, and ordinary matter, respectively. In this model, due to the interaction between these components, and of the corresponding thermodynamical properties, the conservation equations of different cosmological constituents are not satisfied individually. We introduce a thermodynamic description of the Universe, in which two novel physical aspects, the particle number balance equations, and the creation pressures, are considered, thus making the cosmological evolution equations thermodynamically consistent. To constrain the free parameters of the model several observational data sets are employed, including the Planck data sets, Riess 2020, BAO, as well as Pantheon data. By using a scaling ansatz for the dark matter to dark energy ratio, and by imposing constraints from Planck+Riess 2020 data, this model predicts an acceptable value for the Hubble parameter, and thus it may provide a solution to the so-called Hubble tension problem, much debated recently.
description: 29+1 pages, 9 figures including subfigures, 2 tables; Published version
Implications of Mini-EUSO measurements for a space-based observation of UHECRs
Creators: name: Bertaina, M.
name: Battisti, M.
name: Bianciotto, M.
name: Bolmgren, K.
name: Fenu, F.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: Mini-EUSO is the first mission of the JEM-EUSO program on board the International Space Station. It was launched in August 2019 and it is operating since October 2019 being located in the Russian section (Zvezda module) of the station and viewing our planet from a nadir-facing UV-transparent window. The instrument is based on the concept of the original JEM-EUSO mission and consists of an optical system employing two Fresnel lenses of 25 cm each and a focal surface composed of 36 Multi-Anode Photomultiplier tubes, 64 channels each, for a total of 2304 channels with single photon counting sensitivity and an overall field of view of 44$\times$44$^\circ$. Mini-EUSO can map the night-time Earth in the near UV range (predominantly between 290 nm and 430 nm), with a spatial resolution of about 6.3 km and different temporal resolutions of 2.5 $μ$s, 320 $μ$s and 41 ms. Mini-EUSO observations are extremely important to better assess the potential of a space-based detector in studying Ultra-High Energy Cosmic Rays (UHECRs) such as K-EUSO and POEMMA. In this contribution we focus the attention on the results of the UV measurements and we place them in the context of UHECR observations from space, namely the estimation of exposure.
description: 10 pages, 3 figures, ICRC 2023
Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites
Creators: name: Bohannon, L.M.
name: Chao, N.J.
name: Chou, W.-C.
name: Montgomery, N.D.
name: Brickey, W.J.
name: French, M.J.
name: Sung, A.D.
name: Ting, J.P.Y.
name: Macintyre, A.N.
name: Sartor, R.B.
name: Gomes, A.L.C.
name: Li, X.
name: Tan, X.
name: Tam, J.W.
name: Lai, Y.
name: Guo, H.
name: van den Brink, M.R.M.
name: Peled, J.U.
name: Chen, L.
name: Liang, K.
name: Sempowski, G.D.
name: Lu, K.
Publisher: name: American Association for the Advancement of Science
Year: 2020

description: Ionizing radiation causes acute radiation syndrome, which leads to hematopoietic, gastrointestinal, and cerebrovascular injuries. We investigated a population of mice that recovered from high-dose radiation to live normal life spans. These "elite-survivors" harbored distinct gut microbiota that developed after radiation and protected against radiation-induced damage and death in both germ-free and conventionally housed recipients. Elevated abundances of members of the bacterial taxa Lachnospiraceae and Enterococcaceae were associated with postradiation restoration of hematopoiesis and gastrointestinal repair. These bacteria were also found to be more abundant in leukemia patients undergoing radiotherapy, who also displayed milder gastrointestinal dysfunction. In our study in mice, metabolomics revealed increased fecal concentrations of microbially derived propionate and tryptophan metabolites in elite-survivors. The administration of these metabolites caused long-term radioprotection, mitigation of hematopoietic and gastrointestinal syndromes, and a reduction in proinflammatory responses.
An inverse problem for the minimal surface equation
Creators: name: Nurminen, Janne
Publisher: name: arXiv
Year: 2022
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35R30 (Primary) 35J25, 35J61 (Secondary)

description: We use the method of higher order linearization to study an inverse boundary value problem for the minimal surface equation on a Riemannian manifold $(\mathbb{R}^n,g)$, where the metric $g$ is conformally Euclidean. In particular we show that with the knowledge of Dirichlet-to-Neumann map associated to the minimal surface equation, one can determine the Taylor series of the conformal factor $c(x)$ at $x_n=0$ up to a multiplicative constant. We show this both in the full data case and in some partial data cases.
description: 22 pages, Modified assumptions in Theorem 1.1 and added partial data results, changed the proof accordingly, removed Propositions 5.2 and 5.3 for being redundant in this modified case of the main theorem, corrected typos
title: Profile defects caused by inhomogeneous longitudinal strain distribution in roll forming
Creators: name: Kilz, J.
name: Güngör, B.
name: Aign, F.
name: Groche, P.
Publisher: name: Springer
Year: 2025

description: Roll forming is a sheet metal forming operation that incrementally forms flat sheets into a desired profile geometry. The process is characterized by a high material utilization and a high output quantity. Concomitant with these advantages, profile defects such as bow and twist of the profile can occur. In the literature, an inhomogeneous longitudinal strain distribution across the profile cross-section is considered to be the cause of these defects. However, a quantitative cause and effect analysis is missing up to now. This paper presents an analytical model that shows a quantitative relationship between profile defects and the underlying longitudinal strain distributions. The model can be used to calculate the longitudinal strain distribution of a roll-formed profile across its cross-section based on given values for bow and twist or vice versa. It is compared with results from simulations and experiments and clearly reveals the cause for twist and bow in roll forming.