cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Spin Supercurrent, Magnetization Dynamics, and Phi-State in Spin-Textured Josephson Junctions
Creators: name: Kulagina, Iryna
name: Linder, Jacob
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The prospect of combining the dissipationless nature of superconducting currents with the spin-polarization of magnetic materials is interesting with respect to exploring superconducting analogues of topics in spintronics. In order to accomplish this aim, it is pivotal to understand how spin-supercurrents interact dynamically with magnetization textures. We investigate the appearance of a spin-supercurrent and the resulting magnetization dynamics in a textured magnetic Josephson current by using three experimentally relevant models: i) a S/F/S junction with spin-active interfaces, ii) a S/F1/F2/F3/S Josephson junction with a ferromagnetic trilayer, and iii) a Josephson junction containing a domain wall. In all of these cases, the supercurrent is spin-polarized and exerts a spin-transfer torque on the ferromagnetic interlayers which causes magnetization dynamics. Using a scattering matrix formalism in the clean limit, we compute the Andreev-bound states and free energy of the system which is used to solve the Landau-Lifshiftz-Gilbert equation. We compute both how the inhomogeneous magnetism influences the phase-dependence of the charge supercurrent as well as the magnetization dynamics caused by the spin-supercurrent. Using a realistic experimental parameter set, we find that the supercurrent can induce magnetization switching that is controlled by the superconducting phase difference. Moreover, we demonstrate that the combined effect of chiral spin symmetry breaking and interface scattering causes the system to act as a phase battery that may supply any superconducting phase difference phi in the ground state. Such a phi junction is accompanied by an anomalous supercurrent appearing even at zero phase difference, and we demonstrate that the flow direction of this current is controlled by the chirality of the magnetization configuration.
description: 12 pages, 7 figures. Submitted to Phys. Rev. B
Efficient expression of protein coding genes from the murine U1 small nuclear RNA promoters.
Creators: name: Marzluff, W. F.
name: Ramamurthy, L.
name: Bartlett, J. S.
name: Sethna, M.
name: Gowen, S. A.
name: Samulski, R. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: Few promoters are active at high levels in all cells. Of these, the majority encode structural RNAs transcribed by RNA polymerases I or III and are not accessible for the expression of proteins. An exception are the small nuclear RNAs (snRNAs) transcribed by RNA polymerase II. Although snRNA biosynthesis is unique and thought not to be compatible with synthesis of functional mRNA, we have tested these promoters for their ability to express functional mRNAs. We have used the murine U1a and U1b snRNA gene promoters to express the Escherichia coli lacZ gene and the human alpha-globin gene from either episomal or integrated templates by transfection, or infection into a variety of mammalian cell types. Equivalent expression of beta-galactosidase was obtained from < 250 nucleotides of 5'-flanking sequence containing the complete promoter of either U1 snRNA gene or from the 750-nt cytomegalovirus promoter and enhancer regions. The mRNA was accurately initiated at the U1 start site, efficiently spliced and polyadenylylated, and localized to polyribosomes. Recombinant adenovirus containing the U1b-lacZ chimeric gene transduced and expressed beta-galactosidase efficiently in human 293 cells and airway epithelial cells in culture. Viral vectors containing U1 snRNA promoters may be an attractive alternative to vectors containing viral promoters for persistent high-level expression of therapeutic genes or proteins.
e-shape pilot S5-P1 - Hypeweb - Improved historical water availability and quality information service
Creators: name: PECHLIVANIDIS, Ilias
Publisher: name: GEO Knowledge Hub
Year: 2022
Subjects: Water Availability
Hydrological Predictions
Hydropower
e-shape
Swedish Meteorological and Hydrological Institute
European Commission
H2020
Group on Earth Observation
GEO
EuroGEO
Hydrological Predictions for the Environment (HYPE)
Water Resources Management Showcase

description: There is plethora of services on the water-relevant sectors which depend on accurate and reliable hydro-climatic information at scales from regional to global. SMHI has developed and setup the Hydrological Predictions for the Environment (HYPE) model to a number of domains to address a number of user (i.e. hydropower, water authorities, emergency response management centres, general public etc.) needs. The model runs operationally at SMHI's servers for Sweden and the pan-European domain providing open information at different time horizons (i.e. historical records, short range and seasonal forecasts, hydro-climatic projections) to targeted users and the general public.A recently developed global model setup allows improved water information at different geographic locations, and giving the potential at later state to regionalise the service to other regions. The global HYPE model setup is based on high resolution openly available topography, land cover and river discharge data, including delineation of both lakes and rivers, which makes it better adapted than previous setups for assimilation of EO data representing water level, water extent, evapotranspiration, snow extent and snow water equivalent. An operational application of the global HYPE model is currently in its' final development phase, and will provide on a daily basis, historical and near real-time analyses, as well as medium range and (bi-monthly) seasonal forecasts.AcknowledgmentThe e-shape project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement 820852.
Innledning Panelsamtale om diamant åpen tilgang og norsk og nordisk som fagspråk
Creators: name: Aspaas, Per Pippin
name: Steineide Refseth, Per
name: Dijkstra Haugstvedt, Noortje
Publisher: name: Zenodo
Year: 2023

description: Innleding til "Panelsamtale om diamant åpen tilgang og norsk og nordisk som fagspråk"
English title: Introduction to "Panel discussion on diamond open access and Norwegian and Nordic as professional languages"
Regjeringen har som mål at alle vitenskapelige artikler skrevet av forskere tilknyttet offentlige institusjoner skal være åpent tilgjengelig. Samtidig satses det på en styrking av norsk som fagspråk. I denne debatten skal vi se nærmere på en publiseringsmodell som i særlig grad lever opp til mottoet om fellesskap framfor kommersialisering, nemlig "diamant" åpen tilgang, dvs. gratis både for forfatter og leser. Profesjonell kvalitetssikring og publisering av artikler på nett er en ressurskrevende prosess, uansett språk.
Takket være offentlig støtte (NÅHST-ordningen) driftes et knippe norskspråklige tidsskrift etter diamant-modellen. Mange av disse utgis av Universitetsforlaget. Samtidig er det en rik flora av tidsskrift som redigeres av norske og nordiske forskningsmiljøer på andre plattformer, ofte på engelsk eller på en blanding av engelsk og skandinaviske språk. Det er også et betydelig antall norskspråklige tidsskrifter som vurderes å ikke være «sentrale» nok til å inkluderes i NÅHST. Driften av slike tidsskrift krever betydelig dugnadsinnsats. Driftsmidler til redaksjonsmøter, språkvasktjenester og lignende er mangelvare. Hva slags hjelp og oppfølging redaksjonene får til kvalitetssikringsarbeidet varierer også fra plattform til plattform. 
Hvordan kan vi få til et mer bærekraftig system for kvalitetssikrede diamant-tidsskrifter i Norge og de nordiske landene? Debatten vil foregå i form av intervju med de fem paneldeltakerne. Publikum inviteres til å stille spørsmål i chatten.
Paneldeltakere: 
    - Nils Lahlum (forlagssjef forskning, Universitetsforlaget)
    - Kirsten Marie Hartvigsen (førsteamanuensis i religions- og etikkdidaktikk og redaktør for tidsskriftet Acta Didactica Norden)
    - Jenny Gunnarsson Payne (professor i etnologi og redaktør for tidsskriftet Kulturella Perspektiv)
    - Johannes Ljungberg (postdoktor i historie og redaktør for tidsskriftet 1700-tal: Nordic Journal for Eighteenth-Century Studies)
    - Oddmund Løkensgard Hoel (statssekretær, Kunnskapsdepartementet)
Ordstyrer: Per Pippin Aspaas (førstebibliotekar, UiT Norges arktiske universitet)
Arrangementsgruppe:Per Steineide Refseth (universitetsbibliotekar, Høgskolen Innlandet)Noortje Haugstvedt (førstebibliotekar, UiT Norges arktiske universitet)Per Pippin Aspaas (førstebibliotekar, UiT Norges arktiske universitet)
e-shape pilot S6-P2 - GEOSS for Disasters in Urban Environment
Creators: name: PARODI, Antonio
Publisher: name: GEO Knowledge Hub
Year: 2022
Subjects: Extreme weather events
Urban environment
Natural hazards
e-shape
Fondazione CIMA, Centro Internazionale in Monitoraggio Ambientale
European Commission
H2020
Group on Earth Observation
GEO
EuroGEO
GEO Space and Security Community Activity
Disaster Resilience Showcase

description: This pilot application will exploit the new capacities for designing and delivering innovative services for extreme-scale hydro-meteorological modelling, using Copernicus data and core services directly ingested through the Copernicus Open Access Hub APIS, and the DIAS platform, as well as citizen scientists data, to enable more precise predictions and decision-making support for high impact weather events in urban and peri urban environment. Contributing to the Disaster Resilience SBA, one of the main activities listed in the GEO Space and Security Community Activity is to get maximum benefit from the use of large and heterogeneous datasets to potentially fill in the observational and capability gaps at EU decision making level.To this end, the application proposes also the integration of the datasets and tools made available in the frame of the pilot application (weather, citizen science, hydrological and fire models, RASOR platform, Change Detection Maps based on Sentinel-1 and the BEYOND (www.beyond-eocenter.eu) platform – FIREHUB and FloodHub - in synergy with partner NOA and the pilot for resilient ecosystems) for the assessment of impact of natural hazards over areas of interest with regard to human security issues.AcknowledgmentThe e-shape project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement 820852.
Energy current and energy fluctuations in driven quantum wires
Creators: name: Crivelli, Dawid
name: Mierzejewski, Marcin
name: Prelovšek, Peter
Publisher: name: arXiv
Year: 2014
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We discuss the energy current and the energy fluctuations in an isolated quantum wire driven far from equilibrium. The system consists of interacting spinless fermions and is driven by a time--dependent magnetic flux. The energy current is defined by the continuity equation for the energy density which is derived both for homogeneous as well as for inhomogeneous systems. Since the total energy is not conserved in the driven system, the continuity equation includes the source terms which are shown to represent the Joule heating effects. For short times and weak drivings the energy current agrees with the linear response theory. For stronger fields or longer times of driving the system enters the quasiequilibrium regime when the energy current gradually diminishes due to the heating effects. Finally, for even stronger driving the energy current is shown to undergo a damped Bloch oscillations. The energy spread also increases upon driving. However, the time--dependence of this quantity in the low field regime is quite unexpected since it is determined mostly by the time of driving being quite independent of the instantaneous energy of the system.
description: 9 pages, 2 figures, Proc. NATO Adv. Research Workshop Nanotechnology in the security systems, Ed. S. Kruchinin, Yalta, Ukraine, 2013
e-shape pilot S6-P3 - Assessing Geo-hazard vulnerability of Cities & Critical Infrastructures
Creators: name: EZQUERRO, Pablo
Publisher: name: GEO Knowledge Hub
Year: 2022
Subjects: Geo-hazard vulnerability
Urban environment
Human economic losses
e-shape
Instituto Geológico y Minero de España (IGME)
European Commission
H2020
Group on Earth Observation
GEO
EuroGEO
Urban Agenda for the EU
Disaster Resilience Showcase

description: Cities account for most of the population in Europe being the engines of the economic growth, but also posing the greatest environmental, social, political and cultural challenges. In order to address them the Urban Agenda for the EU (ratified in May 2016) focuses on priority themes as to improve the quality of life in urban areas; promote the cooperation between cities in the different member states to stimulate growth and innovation; and identify good projects that can be scaled up and transferred across the EU.Furthermore, the UN SDG Goal 11 "make cities inclusive, safe, resilient and sustainable" aims, among others, to significantly reduce the human and economic losses caused by disasters, with a focus on protecting the people in vulnerable situations. In order to develop safer and more secure cities, products and services exploiting Earth Observation technologies can be used to map vulnerable urban areas that could be potentially affected by geo-hazards.AcknowledgmentThe e-shape project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement 820852.
title: B2B e-auctions and their adoption by procurement professionals of private sector in Greece
title: Αντίστροφες ηλεκτρονικές δημοπρασίες και η υιοθέτησή τους από τους επαγγελματίες procurement του ιδιωτικού τομέα στην Ελλάδα
Creators: name: Μαστορακη Αναστασια
Publisher: name: Technical University of Crete
Year: 2024

description: Τhe adoption of e-auctions by procurement professionals has become increasingly significant worldwide. In Greece, even though the use of e-auctions has been more intense in the public sector for Government-to-Business transactions, the private sector has shown a gradual but noticeable interest in integrating this technology in companies’ procurement strategies for Business-to-Business transactions.
The exploration presented in this thesis delves into the dynamics surrounding the adoption of Business-to-Business electronic auctions by procurement professionals in the private sector of Greece. The purpose of this paper is twofold. First of all, by examining the literature and business world, a theoretical understanding on the topic of e-auctions is provided. This includes the presentation of different types, benefits, challenges, perceptions, influencing factors, as well as notable examples of leading Greek enterprises having adopted e-auctions, which showcase the transformative impact of embracing this state-of-the-art digital procurement methodology. In addition, the second part concerns the quantitative survey that aims at analysing the current state and prospects of e-auction adoption within the Greek private sector. All this information could stand as valuable insights for procurement professionals and stakeholders willing to deepen their knowledge in the evolving landscape of synchronous procurement practices.
Energy-Aware Lease Scheduling in Virtualized Data Centers
Creators: name: Quang-Hung, Nguyen
name: Thoai, Nam
name: Son, Nguyen Thanh
name: Le, Duy-Khanh
Publisher: name: arXiv
Year: 2014
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: Networking and Internet Architecture (cs.NI)
subject: Performance (cs.PF)
subject: FOS: Computer and information sciences
subject: C.2.4; D.4.7

description: Energy efficiency has become an important measurement of scheduling algorithms in virtualized data centers. One of the challenges of energy-efficient scheduling algorithms, however, is the trade-off between minimizing energy consumption and satisfying quality of service (e.g. performance, resource availability on time for reservation requests). We consider resource needs in the context of virtualized data centers of a private cloud system, which provides resource leases in terms of virtual machines (VMs) for user applications. In this paper, we propose heuristics for scheduling VMs that address the above challenge. On performance evaluation, simulated results have shown a significant reduction on total energy consumption of our proposed algorithms compared with an existing First-Come-First-Serve (FCFS) scheduling algorithm with the same fulfillment of performance requirements. We also discuss the improvement of energy saving when additionally using migration policies to the above mentioned algorithms.
description: 10 pages, 2 figures, Proceedings of the Fifth International Conference on High Performance Scientific Computing, March 5-9, 2012, Hanoi, Vietnam
Elevated blood pressures in mice lacking endothelial nitric oxide synthase
Creators: name: Shesely, E. G.
name: Sessa, W. C.
name: Laubach, V. E.
name: Smithies, O.
name: Desai, K. M.
name: Sherman, P. A.
name: Maeda, N.
name: Krege, J. H.
name: Kim, H.- S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: Nitric oxide produced in endothelial cells affects vascular tone. To investigate the role of endothelial nitric oxide synthase (eNOS) in blood pressure regulation, we have generated mice heterozygous (+/−) or homozygous (−/−) for disruption of the eNOS gene. Immunohistochemical staining with anti-eNOS antibodies showed reduced amounts of eNOS protein in +/− mice and absence of eNOS protein in −/− mutant mice. Male or female mice of all three eNOS genotypes were indistinguishable in general appearance and histology, except that −/− mice had lower body weights than +/+ or +/− mice. Blood pressures tended to be increased (by approximately 4 mmHg) in +/− mice compared with +/+, while −/− mice had a significant increase in pressure compared with +/+ mice (≈18 mmHg) or +/− mice (≈14 mmHg). Plasma renin concentration in the −/− mice was nearly twice that of +/+ mice, although kidney renin mRNA was modestly decreased in the −/− mice. Heart rates in the −/− mice were significantly lower than in +/− or +/+ mice. Appropriate genetic controls show that these phenotypes in F2 mice are due to the eNOS mutation and are not due to sequences that might differ between the two parental strains (129 and C57BL/6J) and are linked either to the eNOS locus or to an unlinked chromosomal region containing the renin locus. Thus eNOS is essential for maintenance of normal blood pressures and heart rates. Comparisons between the current eNOS mutant mice and previously generated inducible nitric oxide synthase mutants showed that homozygous mutants for the latter differ in having unaltered blood pressures and heart rates; both are susceptible to lipopolysaccharide-induced death.
The Digital Preservation Polícies of LOCKSS Networks
Creators: name: Andrade
name: Márdero Arellano
Publisher: name: Zenodo
Year: 2024

description: Distributed Digital Preservation (DDP) is by nature capable of ensuring that the promise of guaranteeing the longevity of digital objects stored in digital repositories can be fulfilled. However, for the security guarantee of these digital objects to exist beyond theory, managers of Institutional Repositories (IRs) must build their Digital Preservation Policies (DPP) in accordance with international regulations and standards.In this way, the scope for the research selected a group of IRs that present such characteristics. This work aims to describe the structure of the DPP of the IRs of the LOCKSS networks, observing their compliance with the ISO 14721 and Trustworthy Repositories Audit & Certification: Criteria and Checklist (TRAC) standards, thus highlighting the situation of IRs in Brazil in contrast to that of other repositories on the same network.

The methodology is based on exploratory, descriptive and qualitative research, which analyzes documentation on digital preservation policies, aiming to describe their structures and main characteristics. When using the comparative method, suggestive similarities and contrasts between cases are brought into focus. 

The results revealed that most of the IRs investigated have a well-defined digital preservation management structure that includes websites dedicated to Digital Preservation, Policies Framework, which are available online and are easily accessible. However, in the Brazilian context, there is still a long way to go, as the lack of DPP and other risk mitigation devices sets up an alarming scenario. 

It was concluded that DDP is a practice that provides a guarantee of longevity for the IRs in their networks, but this is only possible due to the fact that the Institutions responsible for the IRs develop their policies in accordance with the LOCKSS guidelines, which follow ISO 14721 and TRAC standards. Furthermore, a policy should not be built without the support of a framework structure to standardize the document.
Estradiol stimulates tyrosine phosphorylation of the insulin-like growth factor-1 receptor and insulin receptor substrate-1 in the uterus.
Creators: name: Clark, G. C.
name: Sebastian, J.
name: DiAugustine, R. P.
name: Richards, R. G.
name: Petrusz, P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: The signaling pathways associated with estrogen-induced proliferation of epithelial cells in the reproductive tract have not been defined. To identify receptor tyrosine kinases that are activated in vivo by 17 beta-estradiol (E2), uteri from ovariectomized mice were examined for enhanced tyrosine phosphorylation of various receptors and a receptor substrate following treatment with this hormone. Within 4 hr after hormone exposure, extracts showed increased phosphotyrosine (P-Tyr) immunoreactivity at several bands, including 170- and 180-kDa; these bands were still apparent at 24 hr after E2. Analysis of immunoprecipitates from uterine extracts revealed that E2 enhanced tyrosine phosphorylation of the insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor substrate-1 (IRS-1) by 6 hr. Comparison of supernatants from IRS-1 and control rabbit IgG immunoprecipitates indicated that the 170-kDa P-Tyr band in extracts was equivalent to IRS-1. The receptors for epidermal growth factor, platelet-derived growth factor, and basic fibroblast growth factor did not exhibit an E2-induced increase in P-Tyr content. The nonestrogenic steroid hormones examined did not stimulate the P-Tyr content of IGF-1R or IRS-1. Immunolocalization of P-Tyr and IRS-1 revealed strong reactivity in the epithelial layer of the uterus from E2-treated mice, suggesting that the majority of P-Tyr bands observed in immunoblots originate in the epithelium. Since hormonal activation of IRS-1 is epithelial, estrogen-specific, and initiated before maximal DNA synthesis occurs following treatment with hormone, this protein, as part of the IGF-1R pathway, may be important in mediating estrogen-stimulated proliferation in the uterus.
Fas-dependent CD4+ cytotoxic T-cell-mediated pathogenesis during virus infection
Creators: name: Frelinger, J. A.
name: Cohen, P. L.
name: Zajac, A. J.
name: Quinn, D. G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: β2-Microglobulin-deficient (β2m−) mice generate a CD4+ major histocompatibility complex class II-restricted cytotoxic T-lymphocyte (CTL) response following infection with lymphocytic choriomeningitis (LCM) virus (LCMV). We have determined the cytotoxic mechanism used by these CD4+ CTLs and have examined the role of this cytotoxic activity in pathogenesis of LCM disease in β2m− mice. Lysis of LCMV-infected target cells by CTLs from β2m− mice is inhibited by addition of soluble Fas-Ig fusion proteins or by pretreatment of the CTLs with the protein synthesis inhibitor emetine. In addition, LCMV-infected cell lines that are resistant to anti-Fas-induced apoptosis are refractory to lysis by these virus-specific CD4+ CTLs. These data indicate that LCMV-specific CD4+ CTLs from β2m− mice use a Fas-dependent lytic mechanism. Intracranial (i.c.) infection of β2m− mice with LCMV results in loss of body weight. Fas-deficient β2m−.lpr mice develop a similar wasting disease following i.c. infection. This suggests that Fas-dependent cytotoxicity is not required for LCMV-induced weight loss. A potential mediator of this chronic wasting disease is tumor necrosis factor (TNF)-α, which is produced by LCMV-specific CD4+ CTLs. In contrast to LCMV-induced weight loss, lethal LCM disease in β2m− mice is dependent on Fas-mediated cytotoxicity. Transfer of immune splenocytes from LCMV-infected β2m− mice into irradiated infected β2m− mice results in death of recipient animals. In contrast, transfer of these splenocytes into irradiated infected β2m−.lpr mice does not cause death. Thus a role for CD4+ T-cell-mediated cytotoxicity in virus-induced immunopathology has now been demonstrated.
e-shape pilot S5-P2 - Satellite Earth Observation-derived water bodies & floodwater record over Europe
Creators: name: MATGEN, Patrick
Publisher: name: GEO Knowledge Hub
Year: 2022
Subjects: Flood
Extremes Hydrologycal Events
Climate Change
e-shape
Luxembourg Institute of Science and Technology
European Commission
H2020
Group on Earth Observation
GEO
EuroGEO
Earth Observation-derived water bodies and floodwater
Water Resources Management Showcase

description: Hydrological extremes such as floods have enormous environmental, social and economic consequences and it is expected that climate change effects combined with a growing population in ill-planned flood-prone coastal and riverine areas will increase their impacts in the future. With more lives and assets at risk, governments are increasingly investing in flood reduction measures to improve or at least maintain the current safety level. Understanding historical trends in flooding greatly enhances the ability of flood managers to take action and to address the underlying risk. The HASARD mapping algorithm that was recently implemented on the European Space Agency's (ESA) Grid Processing On Demand (GPOD) environment enables systematic, automatic and reliable spaceborne Synthetic Aperture Radar-based (SAR) mapping of terrestrial water bodies.The proposed pilot intends to upscale and operationalize the HASARD service so that a water bodies and floodwater record is generated at large scale and over a long period to support flooding-related disaster risk reduction In Europe. By contributing to a better understanding, monitoring and prediction of risks of extreme weather events and enabling a better resilience of our societies to such events, the pilot directly connects to the sustainable development goals 11 (Sustainable cities and communities) and 13 (Take urgent action to combat climate change and its impacts).AcknowledgmentThe e-shape project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement 820852.
Functional organization of the hippocampal memory system
Creators: name: Eichenbaum, H.
name: Young, B.
name: Schoenbaum, G.
name: Bunsey, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: In humans declarative or explicit memory is supported by the hippocampus and related structures of the medial temporal lobe working in concert with the cerebral cortex. This paper reviews our progress in developing an animal model for studies of cortical–hippocampal interactions in memory processing. Our findings support the view that the cortex maintains various forms of memory representation and that hippocampal structures extend the persistence and mediate the organization of these codings. Specifically, the parahippocampal region, through direct and reciprocal interconnections with the cortex, is sufficient to support the convergence and extended persistence of cortical codings. The hippocampus itself is critical to the organization cortical representations in terms of relationships among items in memory and in the flexible memory expression that is the hallmark of declarative memory.
e-shape pilot S6-P1 - EO4D_ASH - EO Data for Detection, Discrimination & Distribution (4D) of Volcanic ash
Creators: name: MONA, Lucia
Publisher: name: GEO Knowledge Hub
Year: 2022
Subjects: Volcanic eruption
Natural disaster
Aviation and airbone hazards
e-shape
CNR - Istituto di Metodologie per l'Analisi Ambientale
European Commission
H2020
Group on Earth Observation
GEO
EuroGEO
EU Directive on European critical infrastructures
Disaster Resilience Showcase

description: Volcanic eruptions are a natural disaster with great impact on society and environment. Even if they are relatively rare, the effects of eruptions on human activities and economy can be very severe. The aviation crisis in 2010, that resulted in 1.3 billion Euro damage, showcased the significant impacts to the general economic activity in Europe.As reported in the EU Directive on European critical infrastructures and the assessment of the need to improve their protection, there is a need to improve the critical infrastructure protection capability in Europe and to help reduce vulnerabilities concerning critical infrastructures. In particular, air traffic is indicated as a European critical infrastructure.AcknowledgmentThe e-shape project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement 820852.
Presentation of paper "Prepare to Preserve: the Harvest Combine for Research Data at Stockholm University and the Systems Inventory"
Creators: name: Philipson, Joakim
Publisher: name: iPRES2024
Year: 2024
Subjects: metadata
digital preservation
research data
repositories
harvesting
transformation

description: ANATOMICALTHEATRE_20240917_1400_PHILIPSON_JOAKIM_V1

Presentation (with demo) of a short paper on the so-called Harvest Combine developed at Stockholm University, at iPRES2024, September 17. Abstract of paper follows:

In the absence yet of a digital archive compliant with the OAIS model requirements Stockholm University (SU) is nevertheless continually developing a "Harvest Combine" tool for harvesting and transformation of metadata and data files from data repositories that are used by SU researchers, such as Figshare, Datadryad and Zenodo. The metadata are collected from these repositories, enriched with metadata from other sources, and then transformed to accord with the Swedish National Archives recent implementation (aka FGS 2.0) of the European Common Specification for Information Packages (E-ARK CSIP) and Specification for Submission Information Packages (E-ARK SIP) versions 2.1.0. The metadata records are then stored in the SU local (temporal) archive together with the associated data files harvested simultaneously. Part of the motivation for this preparatory digital preservation work are the perceived risks of trusting the digital preservation of research data files produced by SU researchers to external repositories, that we do not fully control locally. The end product of this harvest and transformation processing are SIPs (Submission Information Packages), still awaiting future transformation to AIPs (Archival Information Packages) and eventually DIPs (Dissemination Information Packages). The associated data files are not transformed or converted in this first step towards long-term preservation and archiving, but we keep track of the file formats ingested partly by mapping file extensions to mime types in a special registry xml-file, used in the transformation processing and continuously updated whenever "new" file formats are encountered for the first time.

The software scripts that we developed for this "harvest combine" are in BASH Unix Shell, XQuery and XSLT. The processing of metadata, data and scripts occurs locally using Git Bash (for Windows), BaseX and Oxygen XML editor, but is essentially software-tool agnostic. Metadata input sources are e.g. OAI-PMH feeds (DataCite or METS), repository specific APIs (to get necessary file metadata) or generic command line scripts (e.g. for checksums).Only recently we have also created a cross-sectional Digital Preservation Group at Stockholm University Library, whose first task is to create an inventory of external and internal source information systems (e.g. data repositories), together with their local destination archival or storage systems. This inventory is aimed to serve as a basis for a digital preservation plan for future long-term preservation.

Keywords – harvesting, metadata, transformation, research data, repositories, long-term preservation
Measurement of a topological edge invariant in a microwave network
Creators: name: Hu, Wenchao
name: Pillay, Jason Cornelius
name: Wu, Kan
name: Pasek, Michael
name: Shum, Perry Ping
name: Chong, Y. D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optics (physics.optics)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We report on the measurement of topological invariants in an electromagnetic topological insulator analog formed by a microwave network, consisting of the winding numbers of scattering matrix eigenvalues. The experiment can be regarded as a variant of a topological pump, with non-zero winding implying the existence of topological edge states. In microwave networks, unlike most other systems exhibiting topological insulator physics, the winding can be directly observed. The effects of loss on the experimental results, and on the topological edge states, is discussed.
description: 10 pages, 10 figures
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
Creators: name: Xiong, Y.
name: Beach, D.
name: Hannon, G.
name: Alcorta, D. A.
name: Phelps, D.
name: Barrett, J. C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: Human diploid fibroblasts (HDFs) can be grown in culture for a finite number of population doublings before they cease proliferation and enter a growth-arrest state termed replicative senescence. The retinoblastoma gene product, Rb, expressed in these cells is hypophosphorylated. To determine a possible mechanism by which senescent human fibroblasts maintain a hypophosphorylated Rb, we examined the expression levels and interaction of the Rb kinases, CDK4 and CDK6, and the cyclin-dependent kinase inhibitors p21 and p16 in senescent HDFs. Cellular p21 protein expression increased dramatically during the final two to three passages when the majority of cells lost their growth potential and neared senescence but p21 levels declined in senescent HDFs. During this period, p16 mRNA and cellular protein levels gradually rose with the protein levels in senescent HDFs reaching nearly 40-fold higher than early passage cells. In senescent HDFs, p16 was shown to be complexed to both CDK4 and CDK6. Immunodepletion analysis of p21 and p16 from the senescent cell extracts revealed that p16 is the major CDK inhibitor for both CDK4 and CDK6 kinases. Immunoprecipitation of CDK4 and CDK6 and their associated proteins from radiolabeled extracts from senescent HDFs showed no other CDK inhibitors. Based upon these results, we propose that senescence is a multistep process requiring the expression of both p21 and p16. p16 up-regulation is a key event in the terminal stages of growth arrest in senescence, which may explain why p16 but not p21 is commonly mutated in immortal cells and human tumors.
Iron chelates bind nitric oxide and decrease mortality in an experimental model of septic shock.
Creators: name: Wilson, J. G.
name: Williams, D. S.
name: Wolberg, G.
name: Kazmierski, W. M.
name: Thorp, H. H.
name: Smith, S. R.
name: Molina, L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: The hydroxamic acid siderophore ferrioxamine B [Fe
e-shape pilot S4-P2 - mySITE
Creators: name: PETERSEIL, Johannes
Publisher: name: GEO Knowledge Hub
Year: 2022
Subjects: Biodiversity
Ecosystems
Essential Biodiversity Variables
e-shape
Environment Agency Austria (EAA)
European Commission
H2020
Group on Earth Observation
GEO
EuroGEO
GEO Biodiversity Observation Network (GEO BON)
Ecosystem Showcase

description: With global environmental change and biodiversity in decline, the research community is working on developing sensitive, high-resolution indicators for efficient policy support. Over the past 30 years, satellite remote sensing (SRS) has proven to be beneficial in environmental research and monitoring (Pettorelli et al. 2014). The difficulty in quantifying e.g. biodiversity trends has prompted the GEO Biodiversity Observation Network (GEO BON) to propose a framework of Essential Biodiversity Variables (EBV). Ground-truth data on biodiversity is not only essential for providing reliable EBVs from SRS and validating them, it can also be used in a holistic manner (e.g. CEOBE proposed by Bush et al. 2017). Internationally applicable, harmonised and standardised frameworks of in-situ observations are the key to provide standardized retrievable and localised (=site-based) environmental data. We will use the European eLTER Research Infrastructure by making its biodiversity and ecosystem data available through web-based services and providing tools to integrate this data with SRS products (e.g. EBVs). LTER covers a wide range of European ecosystems (Mirtl et al. 2018) and holds long-term, localised datasets on various organisms and habitats, as well as relevant in-situ observations on ecosystem properties (e.g. primary production) and the drivers of changes in biodiversity (climate, air pollution, soil properties, land use, etc.). Focusing on the observation sites (e.g. LTER sites incl. protected areas) workflows will be defined to select relevant data and allow easier access for end users. This should include a) EO data products (e.g. Copernicus services), b) large scale EBVs (e.g. GEO-BON portal), and c) in-situ data provided by both long-term as well as ad-hoc monitoring systems.AcknowledgmentThe e-shape project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement 820852.
Conformal Higgs Inflation
Creators: name: Oda, Ichiro
name: Tomoyose, Takahiko
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We investigate a locally scale-invariant (that is, Weyl-invariant) theory which describes the coupling of gravity and the standard model from the viewpont of the Higgs mechanism and inflation. It is shown that this theory exhibits a peculiar feature of a coupling between the gauge field and the inflaton in a large field limit whereas it nicely describes the standard model coupled to general relativity in a small field limit. Moreover, we discuss a possibility that this Weyl invariant theory could explain the recent BICEP2 measurement by deforming the potential term in an appropriate way, and find it to be difficult to do that even if we introduce a non-analytical type of the potential.
description: 13 pages
Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH.
Creators: name: Ge, H.
name: Gibbs, E.
name: Reardon, J. T.
name: Sancar, A.
name: Hurwitz, J.
name: Pan, Z. Q.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: Transcription factor IIH (TFIIH) is a multisubunit protein complex essential for both the initiation of RNA polymerase class II (pol II)-catalyzed transcription and nucleotide excision repair of DNA. Recent studies have shown that TFIIH copurifies with the cyclin-dependent kinase (cdk)-activating kinase complex (CAK) that includes cdk7, cyclin H, and p36/MAT1. Here we report the isolation of two TFIIH-related complexes: TFIIH
The VMC Survey. XIII. Type II Cepheids in the Large Magellanic Cloud
Creators: name: Ripepi, V.
name: Moretti, M. I.
name: Marconi, M.
name: Clementini, G.
name: Cioni, M-R. L.
name: de Grijs, R.
name: Emerson, J. P.
name: Groenewegen, M. A. T.
name: Ivanov, V. D.
name: Muraveva, T.
name: Piatti, A. E.
name: Subramanian, S.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The VISTA survey of the Magellanic Clouds System (VMC) is collecting deep $K_\mathrm{s}$--band time--series photometry of the pulsating variable stars hosted in the system formed by the two Magellanic Clouds and the Bridge connecting them. In this paper we have analysed a sample of 130 Large Magellanic Cloud (LMC) Type II Cepheids (T2CEPs) found in tiles with complete or near complete VMC observations for which identification and optical magnitudes were obtained from the OGLE III survey. We present $J$ and $K_\mathrm{s}$ light curves for all 130 pulsators, including 41 BL Her, 62 W Vir (12 pW Vir) and 27 RV Tau variables. We complement our near-infrared photometry with the $V$ magnitudes from the OGLE III survey, allowing us to build a variety of Period-Luminosity ($PL$), Period-Luminosity-Colour ($PLC$) and Period-Wesenheit ($PW$) relationships, including any combination of the $V, J, K_\mathrm{s}$ filters and valid for BL Her and W Vir classes. These relationships were calibrated in terms of the LMC distance modulus, while an independent absolute calibration of the $PL(K_\mathrm{s})$ and the $PW(K_\mathrm{s},V)$ was derived on the basis of distances obtained from $Hubble Space Telescope$ parallaxes and Baade-Wesselink technique. When applied to the LMC and to the Galactic Globular Clusters hosting T2CEPs, these relations seem to show that: 1) the two population II standard candles RR Lyrae and T2CEPs give results in excellent agreement with each other; 2) there is a discrepancy of $\sim$0.1 mag between population II standard candles and Classical Cepheids when the distances are gauged in a similar way for all the quoted pulsators. However, given the uncertainties, this discrepancy is within the formal 1$σ$ uncertainties.
description: 18 pages + Appendix (14 pages). Accepted for publication on MNRAS
First detection of [N II] 205 micrometer absorption in interstellar gas
Creators: name: Persson, C. M.
name: Gerin, M.
name: Mookerjea, B.
name: Black, J. H.
name: Olberg, M.
name: Goicoechea, J. R.
name: Hassel, G. E.
name: Falgarone, E.
name: Levrier, F.
name: Menten, K. M.
name: Pety, J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present high resolution [NII] 205 micrometer ^3P_1-^3P_0 spectra obtained with Herschel-HIFI towards a small sample of far-infrared bright star forming regions in the Galactic plane: W31C (G10.6-0.4), W49N (G43.2-0.1), W51 (G49.5-0.4), and G34.3+0.1. All sources display an emission line profile associated directly with the HII regions themselves. For the first time we also detect absorption of the [NII] 205 micrometer line by extended low-density foreground material towards W31C and W49N over a wide range of velocities. We attribute this absorption to the warm ionised medium (WIM) and find N(N^+)\approx 1.5x10^17 cm^-2 towards both sources. This is in agreement with recent Herschel-HIFI observations of [CII] 158 micrometer, also observed in absorption in the same sight-lines, if \approx7-10 % of all C^+ ions exist in the WIM on average. Using an abundance ratio of [N]/[H] = 6.76x10^-5 in the gas phase we find that the mean electron and proton volume densities are ~0.1-0.3 cm^-3 assuming a WIM volume filling fraction of 0.1-0.4 with a corresponding line-of-sight filling fraction of 0.46-0.74. A low density and a high WIM filling fraction are also supported by RADEX modelling of the [NII] 205 micrometer absorption and emission together with visible emission lines attributed mainly to the WIM. The detection of the 205 micrometer line in absorption emphasises the importance of a high spectral resolution, and also offers a new tool for investigation of the WIM.
description: 7 pages, 4 figures, accepted for publication in Astronomy & Astrophysics, 11 June 2014
Leukemia inhibitory factor (LIF) and LIF receptor expression in human endometrium suggests a potential autocrine/paracrine function in regulating embryo implantation.
Creators: name: Lessey, B. A.
name: Pollard, J. W.
name: Stewart, C. L.
name: Cullinan, E. B.
name: Anderson, P. S.
name: Abbondanzo, S. J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: The uterine expression of leukemia inhibitory factor (LIF) is essential for embryo implantation in the mouse. Here, we describe the expression of LIF, related members of this group of cytokines, oncostatin M and ciliary neurotrophic factor, and the LIF receptor beta and glycoprotein gp130 in normal human tissues and in the endometrium of fertile women. Our results show that LIF is the only one of these factors expressed at detectable levels in the endometrium of women of proven fertility. LIF expression is restricted to the endometrial glands during the secretory/postovulatory phase but is not present in the endometrium during the proliferative/preovulatory phase. The LIF receptor beta is expressed during the proliferative and secretory phases of the cycle and is restricted to the luminal epithelium. The associated signal-transducing component of the LIF receptor, gp130, is also expressed in both the luminal and glandular epithelium throughout the cycle. These results suggest that uterine expression of LIF in humans, like mice, may have a role in regulating embryo implantation, possibly through an autocrine/paracrine interaction between LIF and its receptor at the luminal epithelium.
Leukocyte lipid body formation and eicosanoid generation: cyclooxygenase-independent inhibition by aspirin.
Creators: name: Morham, S. G.
name: Weller, P. F.
name: Langenbach, R.
name: Smithies, O.
name: Payne, J. L.
name: Bozza, P. T.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: Lipid bodies, cytoplasmic inclusions that develop in cells associated with inflammation, are inducible structures that might participate in generating inflammatory eicosanoids. Cis-unsaturated fatty acids (arachidonic and oleic acids) rapidly induced lipid body formation in leukocytes, and this lipid body induction was inhibited by aspirin and nonsteroidal antiinflammatory drugs (NSAIDs). Several findings indicated that the inhibitory effect of aspirin and NSAIDs on lipid body formation was independent of cyclooxygenase (COX) inhibition. First, the non-COX inhibitor, sodium salicylate, was as potent as aspirin in inhibiting lipid body formation elicited by cis-fatty acids. Second, cis-fatty acid-induced lipid body formation was not impaired in macrophages from COX-1 or COX-2 genetically deficient mice. Finally, NSAIDs inhibited arachidonic acid-induced lipid body formation likewise in macrophages from wild-type and COX-1 and COX-2-deficient mice. An enhanced capacity to generate eicosanoids developed after 1 hr concordantly with cis-fatty acid-induced lipid body formation. Arachidonic and oleic acid-induced lipid body numbers correlated with the enhanced levels of leukotrienes B$_{4}$ and C$_{4}$ and prostaglandin E$_{2}$ produced after submaximal calcium ionophore stimulation. Aspirin and NSAIDs inhibited both induced lipid body formation and the enhanced capacity for forming leukotrienes as well as prostaglandins. Our studies indicate that lipid body formation is an inducible early response in leukocytes that correlates with enhanced eicosanoid synthesis. Aspirin and NSAIDs, independent of COX inhibition, inhibit cis-fatty acid-induced lipid body formation in leukocytes and in concert inhibit the enhanced synthesis of leukotrienes and prostaglandins.