cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Imaging of Novel Stem Cell Therapy Targeting Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Despite surgical removal of the primary breast tumor in patients with localized disease, relapse at local or distant sites may occur because of the presence of micro-metastases that are undetectable at the time of diagnosis. The development of new cytotoxic agents and radiation therapy techniques, administered as adjuvant therapy after surgery, has improved patient survival. However, adjuvant therapy is limited by discomforting side effects and a relapse rate of 20-40%. Given these serious drawbacks, it is important to develop novel approaches for the treatment of breast cancer.

 Our interest in using stem cells as biological “search and destroy” vehicles came from recent findings showing that mesenchymal stem cells can home to breast tumors. However, in general adult stem cells have limited capacity for self-renewal, which can restrict clinical application at a large scale. By contrast, embryonic stem cells are capable of unlimited self-renewal and differentiation into all cell types within the body, including adult stem cells. For these reasons, we hypothesize that human embryonic stem cells, when properly characterized and tested, can lead to major breakthroughs in the treatment of breast cancer.

 The proposal is divided into two aims. In Aim 1, we will differentiate human embryonic stem cells into natural killer cells (hESC-NKs) and endothelial cells (hESC-ECs). The natural killer cells can search and destroy local and metastasized breast cancer cells. The endothelial cells can home into breast tumors, incorporate into their vasculature, and later activated to undergo programmed cell death, thereby starving the breast tumors of essential nutrients and oxygen. In Aim 2, we seek to understand the underlying molecular mechanism by which hESC-NKs and hESC-ECs can home in to the breast tumors. We will use custom-designed antibody array that probes for >500 cytokines (signaling proteins regulating immune responses) simultaneously. The identification of specific cytokines released within the breast tumor microenvironment to attract circulating stem cells is a promising approach for determining the temporal kinetics of cytokine activation in relation to growth of tumors.
Pipistrellus endoi Imaizumi 1959
Creators: name: Jo, Yeong-Seok
name: Baccus, John T.
name: Koprowski, John L.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Vespertilionidae
Pipistrellus
Pipistrellus endoi

description: Pipistrellus endoi Imaizumi, 1959 —Endo’s Pipistrelle
Pipistrellus endoi Imaizumi, 1959 p.363; Type locality- Iwate, Japan; Son, 2001 p.108.
Range: Son (2001) collected one specimen near Masan, Gyeongsangnam Province in 1986.
Remarks: Since the first collection at the southeastern tip of Korea, near Japan (Son 2001), no other specimen of P. endoi has been collected in Korea. Therefore, without other specimens acquired in almost 30 years, we consider the species a vagrant. Pipistrellus endoi has been considered as an endemic bat in Japan (Kawai 2009a).
Conservation status: Pipistrellus endoi was listed ‘Endangered’ on the IUCN Red List (Maeda 2008).
description: Published as part of Jo, Yeong-Seok, Baccus, John T. & Koprowski, John L., 2018, Mammals of Korea: a review of their taxonomy, distribution and conservation status, pp. 1-216 in Zootaxa 4522 (1) on page 61, DOI: 10.11646/zootaxa.4522.1.1, http://zenodo.org/record/2610198
Pipistrellus abramus
Creators: name: Jo, Yeong-Seok
name: Baccus, John T.
name: Koprowski, John L.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Vespertilionidae
Pipistrellus
Pipistrellus abramus

description: Pipistrellus abramus (Temminck, 1838) —Japanese Pipistrelle
Ƒespertilio abramus Temminck, 1838 p.232; Type locality- Nagasaki, Japan.
Ƒ. akokomuli Temminck, 1838 p.57: Type locality-Nagasaki, Japan.
Pipistrellus javanicus: Corbet, 1978 p.53; Han, 1994 p.45; Won & Smith, 1999 p.14.
P. abramus: Won, 1968 p.110; Yoon, 1992 p.43; Son, 2001 p.106; Yoon, 2010 p.48; Jo et al., 2012 p.251.
P. abramus abramus: Won, 1958 p.455; Won, 1967 p.319.
Range: The distribution of P. abramus extends throughout Korea, including Jeju Island (Won & Smith 1999; Jo et al. 2012; Fig. 37).
Remarks: The species was formerly classified as a subspecies of P. javanicus (Won & Smith 1999) but was elevated to the species, P. abramus (Simmons 2005).
Conservation status: Japanese pipistrelles were once common in Korea, but populations substantially decreased since concrete houses became standard. The governments of Jeollanam Province and Gyeonggi Province designated this species as protected.
description: Published as part of Jo, Yeong-Seok, Baccus, John T. & Koprowski, John L., 2018, Mammals of Korea: a review of their taxonomy, distribution and conservation status, pp. 1-216 in Zootaxa 4522 (1) on pages 59-60, DOI: 10.11646/zootaxa.4522.1.1, http://zenodo.org/record/2610198
Batozonellus lacerticida
Creators: name: Gadallah, Neveen S.
name: Schmid-Egger, Christian
name: Brothers, Denis J.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Pompilidae
Batozonellus
Batozonellus lacerticida

description: Batozonellus lacerticida (Pallas, 1771)
Distribution in the Arabian Peninsula: Kuwait (Al-Houty 1989, 1997 both as Batazonellus lacerticida).
Extralimital distribution: Palaearctic from Portugal to Japan and Sweden to Iran, Morocco, Tunisia (Ghahari et al. 2014).
Remarks: Although this species has recently been included in the genus Parabatozonus Yasumatsu, 1936 in two recent country-limited catalogues (Loktionov & Lelej 2017a, b), we prefer to retain it in Batozonellus pending more detailed analysis.
description: Published as part of Gadallah, Neveen S., Schmid-Egger, Christian & Brothers, Denis J., 2020, Biodiversity of the aculeate wasps (Hymenoptera: Aculeata) of the Arabian Peninsula: Vespoidea, Pompilidae, pp. 153-173 in Zootaxa 4754 (1) on page 161, DOI: 10.11646/zootaxa.4754.1.16, http://zenodo.org/record/3719039
Additional file 1: of Applying a community-based participatory research approach to improve access to healthcare for Eritrean asylum-seekers in Israel: a pilot study
Creators: name: Gottlieb, Nora
name: Weinstein, Tomer
name: Mink, Jonah
name: Habtom Ghebrezghiabher
name: Zebib Sultan
name: Reichlin, Rachel
Publisher: name: Figshare
Year: 2017
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: Migrant Health Market Survey. (DOCX 35Â kb)
On the matter of memory
Creators: name: Morgan, Alexander D.
Publisher: name: No Publisher Supplied
Year: 2014

description: Humans and other animals are intentional agents; they are capable of acting in ways that are caused and explained by their reasons. Reasons are widely held to be mediated by mental representations, but it is notoriously difficult to understand how the intentional content of mental representations could causally explain action. Thus there is a puzzle about how to `naturalize' intentional agency. The present work is motivated by the conviction that this puzzle will be solved by elucidating the neural mechanisms that mediate the cognitive capacities that are distinctive of intentional agency.    Two main obstacles stand in the way of developing such a project, which are both manifestations of a widespread sentiment that, as Jerry Fodor once put it, ``notions like computational state and representation aren't accessible in the language of neuroscience''. First, C. Randy Gallistel has argued extensively that the mechanisms posited by neuroscientists cannot function as representations in an engineering sense, since they allegedly cannot be manipulated by the computational operations required to generate structurally complex representations. Second, William Ramsey has argued that neural mechanisms in fact do not function as representations in an explanatory sense, since the explanatory role they play is more like that of a causal relay rather than an internal `stand-in' for external entities.    I argue that the criticisms developed by Gallistel and Ramsey rest on a misapplication of relevant theoretical notions from computer science, and an impoverished appreciation of the rich variety of mechanisms posited in contemporary neuroscience. My central argument, though, is that the conception of representation presupposed by those researchers, according to which representations have the same abstract structure as the external systems they represent, encompasses states in all sorts of systems, including mindless systems such as plants. Thus these `structural representations' are not distinctively cognitive representations, and although they play an important explanatory role in neuroscience and other disciplines, they cannot on their own elucidate the nature of intentional agency. I conclude by sketching some ways in which neuroscientists are beginning to elucidate the representational mechanisms that do mediate distinctively cognitive capacities. Thus, by removing the obstacles put in place by Gallistel and Ramsey, this work clears a path toward the `naturalization' of agency in terms of neural mechanisms.
Novel Small Proteins for PET Imaging of Breast Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Human epidermal growth factor receptor type-2 (HER2) is a protein over-expressed in 25-30% of human breast cancers. HER2 targeted breast cancer therapy such as Trastuzumab (Herceptin) is commonly used in clinic. It also serves as a prognostic indicator of patient survival and a predictive marker of response to anti-tumor treatment. Thus a technology for accurate testing HER2 status is very important and has great impact on clinical management of breast cancer patients. We are particularly interested in developing positron emission tomography (PET) agents for HER2 imaging because of the high sensitivity, high spatial resolution, strong quantification ability, good safety (radiation no more than an ordinary X-ray test) and great potential for clinical translation of PET.

 This project is initially focused on the design, synthesis and evaluation of small proteins with novel structure for their HER2 binding affinities. This will be measured by Surface Plasmon Resonance (SPR) Biacore analysis. This technology allows fully automated, real time measurement of binding kinetics between two or more molecules. Different strategies including sequence modifications and protein cyclization through disulfide bridges will be applied to achieve small proteins with high HER2 binding affinity. The most promising small proteins will then be labeled with a PET radioisotope, 18F. Finally, we will investigate the HER2 targeting ability of our probes using breast cancer xenografts (human tumor cell lines grown in mice) using small animal PET imaging. Finally, the PET probe with the best tumor imaging property will be studied in more detail for its ability to more accurately determine the HER2 status in tumors. The correlation between the tumor uptakes obtained from quantitation analysis of PET images and tumor HER2 levels measured by immunohistochemistry and Western blot analysis will be analyzed. In summary, this project represents the first trial to test the small protein scaffold as a platform for the imaging of HER2 expression. The HER2 targeted PET molecular probe developed in this research will hopefully provide a real-time, non-invasive assay of the overall tumor HER2 expression in patients.

 If successful, a new PET imaging agent envisioned in this project will have broad implication in clinic, such as stratification of breast cancer patients for HER2 targeted drug therapy and surveillance of therapeutic efficacy. If the imaging agent demonstrates promising results in breast cancer animal models, we will further test their safety profile and move into clinical breast cancer imaging trial.
Additional file 3: of Declining amenable mortality: a reflection of health care systems?
Creators: name: Gianino, Maria
name: Lenzi, Jacopo
name: Fantini, Maria
name: Ricciardi, Walter
name: Damiani, Gianfranco
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: BĂśhmâ  s health care system classification: a summary. (PDF 14Â kb)
In vitro screening system for macrosteatosis reversal in liver cells
Creators: name: Nativ, Nir Israel
Publisher: name: No Publisher Supplied
Year: 2014

description: Orthotopic liver transplantation is the only therapeutic option for end-stage liver disease, but it is limited by the scarcity of suitable grafts. Macrosteatotic livers exhibit elevated triglyceride (TG) levels in the form of large lipid droplets (LDs), elevated reactive oxygen species (ROS) and reduced adenosine triphosphate (ATP) levels in the liver’s hepatocytes. These abnormalities increase sensitivity of hepatocytes to ischemia and reperfusion (I/R) stress during transplantation and to increased hepatocyte death and graft failure following transplantation. Macrosteatosis reversal several weeks prior to live-donor liver transplantation reduces graft I/R sensitivity and enables successful transplantation. However, to apply this concept to livers from deceased donors, the defatting process must be accelerated using ex-vivo perfusion with defatting agents. To explore macrosteatosis defatting phenomena and to identify potent defatting agents prior to whole liver studies, an in-vitro system simulating macrosteatosis was developed.    Primary rat hepatocyte cultures incubated for several days with elevated free fatty acid (FFA) levels exhibited characteristics of clinical macrosteatosis based on LD morphology, elevated TG levels and elevated sensitivity to hypoxia and reoxygenation (H/R) induced stress, simulating I/R. This novel system was used to explore the ability of selected defatting cocktails to reverse macrosteatosis and reduce H/R sensitivity as measured by hepatocyte viability and function.     We  found that pretreatment of macrosteatotic cultures with an L-carnitine supplemented defatting cocktail under hyperoxic conditions for 48h prior to H/R induction led to a ~82% reduction in the number of macrosteatotic LDs and to a ~5&% reduction in intrahepatic TG by promoting bete-oxidation of FFAs. Furthermore, this treatment reduced ROS stress by ~32%, elevated the ATP levels to that of lean controls and fully abolished H/R associated hepatic death. Treated cultures maintained ~83% viability and exhibited superior functionality compared to untreated macrosteatotic cultures as assessed by urea secretion and bile canalicular transport 48h post H/R stress.     The developed system is suitable for exploring additional defatting cocktails that may reverse macrosteatosis and elevated H/R sensitivity. The developed in-vitro defatting routine can now be scaled-up for whole organ perfusion systems to recover macrosteatotic livers in order to mitigate the persistent shortage of suitable livers for transplantation.
Leptomantella (Leptomantella) Uvarov 1940
Creators: name: Schwarz, Christian J.
name: Konopik, Oliver
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Mantodea
Tarachodidae
Leptomantella

description: Leptomantella (Leptomantella) Uvarov, 1940
= Leptomantis Giglio-Tos, 1915
These are slender, delicate-looking, arboricolous mantids. Several not well-defined species occur in SE Asia. The genus is in need of revision.
Leptomantella (L.) albella (Burmeister, 1838) §
Mantis (Thespis) albella Burmeister, 1838: 533
= Leptomantis sumatrana Giglio-Tos, 1915: 88
Distribution. S China, Malay Peninsula, W Java, Sumatra, Borneo, Bawean, N Sulawesi, Talaud Islands, Philippines (Werner 1933, Beier 1942, Ehrmann 2002; AFUW).
Bornean records. Sarawak: Lanjak Entimau (6 m, CSUB/SFDC), Mt. Dulit (Beier 1937); Brunei: Kuala Belalong (OK in situ); Sabah: Crocker Range (CSUB); Kalimantan: Marah (Werner 1933), Mentawir (Beier 1958).
Remarks. Both sexes are easily attracted to lights. Their systematic placement remains unclear. This and the following genus are not related to Caliris Giglio-Tos, 1915 and Gildella Giglio-Tos, 1927, as suggested by Beier (1935c, 1964 & 1968) and Ehrmann & Roy (in: Ehrmann 2002), and none of these genera shows any closer relationships to the Tarachodinae, with which they were united into one family. The molecular study by Svenson & Whiting (2009) indeed did neither confirm the assumed monophyly of Caliridinae (sensu Ehrmann 2002) nor a close relationship to Tarachodidae.
Leptomantella (L.) fragilis (Westwood, 1889)
Musonia fragilis Westwood, 1889
Distribution. Sumatra, Java, Borneo, Labuan, Palawan, Sulawesi (Werner 1933, 1934, Beier 1966, Ehrmann 2002).
Bornean records. Sabah: Sandakan (Hebard 1920), Labuan Island (Hebard 1920), Poring Hot Springs (Helmkampf et al. 2007; CSUB), Danum Valley (Helmkampf et al. 2007); Kalimantan: Pajan River (Werner 1930), Mentawir (Beier 1958), Wain (Beier 1958).
description: Published as part of Schwarz, Christian J. & Konopik, Oliver, 2014, An annotated checklist of the praYing mantises (Mantodea) of Borneo, including the results of the 2008 scientific expedition to Lanjak Entimau Wildlife SanctuarY, Sarawak, pp. 130-168 in Zootaxa 3797 (1) on page 138, DOI: 10.11646/zootaxa.3797.1.12, http://zenodo.org/record/226038
New technology to enhance PET's role in breast CA management
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Positron Emission Tomography (PET) has not yet had significant impact upon breast cancer management because it is currently impractical for routine breast imaging. Currently employed PET systems cannot see breast cancer lesions smaller than about ½ inch. Furthermore, standard systems are quite large, very expensive, and require long scan times. Thus, the current role for PET in breast cancer management is limited to identifying advanced or recurring disease in a location removed from the breast clinic. In PET a small amount of a radioactive chemical is introduced into the body. The radiochemical is designed to accumulate in increased amounts in cancer cells due to their increased biochemical activity (rather than structural properties). A PET system images a form of energy called photons emitted from the radiochemical. We will directly address the limitations of existing PET technology by developing an advanced, compact, cost effective system dedicated to breast imaging in the breast clinic. In this project, we propose to explore a novel photon sensing technology appropriate for this high-performance PET camera. The new photon sensor proposed is made from a crystal of the elements cadmium, zinc, and telluride and configured in a special way to form a novel breast-dedicated PET system with superior lesion visualization, shorter scan time, and a factor of 10 lower cost.

 The proposed research will experimentally demonstrate the high performance of the photon sensors, verify they lead to improved cancer visualization using computer simulations, and result in a blue-print design of the proposed full breast-dedicated PET system to be built in the next phase. Our aims for this project include:

 1. Build and test four photon sensors.

 2. Procure electronics that will capture the sensor electrical signals onto a computer.

 3. Arrange two pairs of adjacent sensors facing each other. Measure the photon collection rate and the ability to localize the location, energy, and time of arriving photons using a PET radioactivity source. These data are important for understanding the sensor’s performance for PET.

 4. Develop a computer simulation of the breast-dedicated PET system and realistic PET radiochemical distribution in breast tissue with spherical tumors and in the nearby heart and torso. Perform a simulated PET scan of the configuration for 30 seconds, reconstruct images that contain the tumors, and show that

 The work will be done in collaboration with Dr. James Matteson at the UC San Diego Center for Astrophysics and Space Studies (CASS). The project will utilize CASS scientist’s expertise in photon detection used in the field of astrophysics to assist us in developing advanced PET imaging modules that will be used to build the full system.
Hypsugo Kolenati 1856
Creators: name: Jo, Yeong-Seok
name: Baccus, John T.
name: Koprowski, John L.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Vespertilionidae
Hypsugo

description: Genus Hypsugo Kolenati, 1856
Hypsugo was once regarded as a Subgenus of Pipistrellus (Simmons 2005), although Horáček and Hanák (1986) viewed Hypsugo as a distinct genus (followed by Juste & Paunovic 2016). Genetic and karyological analyses did not support a close relationship between Pipistrellus and Hypsugo (Kruskop 2012). One species, H. alaschanicus occurs in Korea. With Vespertilio, Hypsugo represents the Tribe Vespertilionini in the Subfamily Vespertilionae.
description: Published as part of Jo, Yeong-Seok, Baccus, John T. & Koprowski, John L., 2018, Mammals of Korea: a review of their taxonomy, distribution and conservation status, pp. 1-216 in Zootaxa 4522 (1) on page 61, DOI: 10.11646/zootaxa.4522.1.1, http://zenodo.org/record/2610198
A product formula for certain Littlewood-Richardson coefficients for Jack and Macdonald polynomials
Creators: name: Naqvi, Yusra Fatima
Publisher: name: No Publisher Supplied
Year: 2014

description: Jack polynomials generalize several classical families of symmetric polynomials, including Schur polynomials, and are further generalized by Macdonald polynomials. In 1989, Richard Stanley conjectured that if the Littlewood-Richardson coefficient for a triple of Schur polynomials is 1, then the corresponding coefficient for Jack polynomials can be expressed as a product of weighted hooks of the Young diagrams associated to the partitions indexing the coefficient. We prove a special case of this conjecture in which the partitions indexing the Littlewood-Richardson coefficient have at most 3 parts. We also show that this result extends to Macdonald polynomials.
Inhibition of Breast Cancer Growth by Vitamin D
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: This project will examine the efficacy of the active form of vitamin D, called “calcitriol”, in the treatment of breast cancer using a mouse model. In previous studies calcitriol has shown only modest activity. However, calcitriol has several new actions that we recently discovered that indicate it would be extremely active in combination with non-steroidal anti-inflammatory drugs (NSAIDs) and aromatase inhibitors (AIs). Prostaglandins (PGs) have been implicated in causing cancers in general including breast cancer and simulating progression and metastasis. We discovered that calcitriol inhibits PGs by three different molecular pathways. This would be useful for therapy, because PGs are major stimulators of aromatase activity in breast cancer. By inhibiting PGs, calcitriol would indirectly reduce aromatase, the enzyme critical for estrogen synthesis. In addition, we found that calcitriol directly inhibits the synthesis of aromatase thus acting by two pathways to reduce estrogens in breast cancer. Also, calcitriol decreases the levels of the estrogen receptor, reducing the ability of estrogens to stimulate breast cancer growth. Our preliminary experiments in cultured breast cancer cells demonstrate that calcitriol in combination with NSAIDs or AIs show a synergistic activity to inhibit breast cancer cell growth.

 The general methodology will use molecular biology techniques to study changes in gene expression and protein levels in breast cancer xenografts in immunodeficient (“nude”) mice. These studies will focus on therapy with calcitriol in combination with NSAIDs and/or with AIs.

 Calcitriol is an orally active, available drug that has been shown in clinical trials to have the ability to delay progression and prolong survival in prostate cancer patients without causing serious side-effects. Calcitriol reduced the toxicity of taxanes when given in combination. We postulate similar activity in breast cancer patients and propose combination therapy with NSAIDs or AIs. We envision these studies to rapidly pave the way to clinical trials in breast cancer patients.
Batozonellus fuliginosus
Creators: name: Gadallah, Neveen S.
name: Schmid-Egger, Christian
name: Brothers, Denis J.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Pompilidae
Batozonellus
Batozonellus fuliginosus

description: Batozonellus fuliginosus (Klug, 1834)
Distribution in the Arabian Peninsula: Qatar (Walker & Pittaway 1987), Saudi Arabia (Abu Zoherah et al. 1993; Gadallah & El-Barty 2011), United Arab Emirates (Schmid-Egger 2017 as Parabatozonus fuliginosus), Yemen (Kohl 1906 as Pompilus fuliginosus; Wahis 2000a).
Extralimital distribution: Whole Africa to Iran and Pakistan (Arnold 1937; Priesner 1955; Junco y Reyes 1963; Ebrahimi et al. 2008).
description: Published as part of Gadallah, Neveen S., Schmid-Egger, Christian & Brothers, Denis J., 2020, Biodiversity of the aculeate wasps (Hymenoptera: Aculeata) of the Arabian Peninsula: Vespoidea, Pompilidae, pp. 153-173 in Zootaxa 4754 (1) on page 161, DOI: 10.11646/zootaxa.4754.1.16, http://zenodo.org/record/3719039
Leptomantella (Aetaella) Hebard 1920
Creators: name: Schwarz, Christian J.
name: Konopik, Oliver
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Mantodea
Tarachodidae
Leptomantella

description: Leptomantella (Aetaella) Hebard, 1920
Although considered to be a subgenus of Leptomantella by Beier (1935c), we consider it distinct enough to justify revalidation of generic status. Arboricolous.
Leptomantella (Aetaella) bakeri Hebard, 1920 §
Distribution. N Borneo, Philippines (Hebard 1920, Ehrmann 2002). Bornean records. Sarawak: Mt. Mulu (CS in situ); Brunei: Labi Road (OK in situ); Sabah: Sandakan (Hebard 1920), Tawau Hills (AFUW).
description: Published as part of Schwarz, Christian J. & Konopik, Oliver, 2014, An annotated checklist of the praYing mantises (Mantodea) of Borneo, including the results of the 2008 scientific expedition to Lanjak Entimau Wildlife SanctuarY, Sarawak, pp. 130-168 in Zootaxa 3797 (1) on pages 138-139, DOI: 10.11646/zootaxa.3797.1.12, http://zenodo.org/record/226038
Visions of the divine
Creators: name: Nayyar, Reshma
Publisher: name: No Publisher Supplied
Year: 2014

description: Baciccio’s Triumph of the Name of Jesus (16&6-16&9) decorating the nave vault of the Gesù in Rome is a stunning exemplar of illusionistic Baroque ceiling painting. Its composition centers on the blazing letters IHS representing the Name of Jesus in the form of the Jesuit monogram that attracts the Blessed and repels the Damned. Its imagery has been widely accepted as a celebration of the Church Triumphant. My dissertation reexamines the meaning of the Triumph based on textual and visual evidence in conjunction with a consideration of its site in the mother church of the Society of Jesus, which reveals a conscious glorification of the Jesuit founder, Saint Ignatius of Loyola, even though he is not represented in the composition. Through an analysis of devotional and emblematic literature from the sixteenth and seventeenth centuries, I show that the allegorical and symbolic imagery of the Triumph, with its allusions to Ignatius, would have been understood by devout and erudite audiences at the Gesù.   My dissertation further investigates the substitution of Joshua Stopping the Sun projected for the apse with Baciccio’s Adoration of the Mystic Lamb (1680-1683), in light of the original commission, the change in theme, and the relationship to the Triumph of both subjects. This shift in subject has been relegated to a mere passing mention and otherwise overlooked in scholarship on the frescoes. Based on a previously ignored connection between Ignatius and the Old Testament general Joshua, and on consideration of contemporary exigencies faced by the Society, I argue that the Jesuits’ decision to replace the subject of Joshua was to avoid antagonizing the reigning pope Innocent XI. Previously unpublished letters authored by the Jesuit Lazzero Sorba betray the precarious position in which Father General Oliva and the Jesuits found themselves during the reign of Innocent XI and support my claim. Finally, an analysis of the circumstances leading up to this change in subject demonstrates that Baciccio’s frescoes in the Gesù were not conceived as a unified program as has been accepted in scholarship, and they are more accurately characterized as a cycle.
Discovery of fusion genes in breast cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Chromosome rearrangements resulting in the expression of fusions or chimeras between two different genes is a common mechanism for activation of cancer genes in blood cancers, where the fusion gene contributes to cancer development but is also a useful biomarker for diagnosis and target for therapy. While common in blood cancers, fusion genes have been considered rare in solid tumors like breast cancer. The discovery of fusion genes in breast cancer would provide a new foothold to study and understand the pathogenesis of this disease, as well as new opportunities for diagnosis and therapy. Fusion genes were discovered in prostate cancer only three years ago and already that knowledge is being translated towards improved diagnosis and therapy. A similar impact would be expected in breast cancer.

 We recently developed and validated the feasibility of a novel microarray-based approach for discovery of fusion genes. The approach is based on detecting transcribed exonic breakpoints and fusion junction sequences. The goals for this project include, (1) design and validation of a custom screening array to detect gene fusions; (2) use the array to profile a collection of breast cancer cell lines and clinical specimens; (3) validation of any identified fusions by reverse-transcription polymerase chain reaction (RT-PCR), and analyzing their prevalence in a large independent set of clinical samples; and (4) functional characterization of at least one fusion gene through studies of breast epithelial cells in culture. In parallel, we will also incorporate “next-generation” DNA sequencing approaches to find fusion gene candidates.

 The discovery of recurrent fusion gene(s) in breast cancer would provide a significant advance in our understanding of breast cancer pathogenesis, as well as important opportunities for improved diagnosis and therapy, much as has occurred with the recent discovery of oncogenic fusion genes in prostate cancer.
Hypsugo alaschanicus
Creators: name: Jo, Yeong-Seok
name: Baccus, John T.
name: Koprowski, John L.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Vespertilionidae
Hypsugo
Hypsugo alaschanicus

description: Hypsugo alaschanicus (Bobrinskoj, 1926) —Alashanian Pipistrelle
Eptesicus alaschanicus Bobrinskoj, 1926 p.98; Type locality- Alashan Range, Mongolia.
Amblyotus velox Ognev, 1927 p.154; Type locality- Vladivostok, Russia
Pipistrellus savii coreensis Imaizumi, 1955 p.56; Won, 1958 p.455; Won, 1967 p.324; Won, 1968 p.111; Corbet, 1978 p.54.
P. savii velox: Won, 1958 p.455; Won, 1967 p.325.
P. savii: Won, 1968 p.111; Corbet, 1978 p.54; Han, 1994 p.45; Won & Smith, 1999 p.14; Son, 2001 p.109.
P. coreensis: Yoshiyuki, 1985 p.129; Yoon, 1992 p.44; Yoon, 2004 p.72; Yoon, 2010 p.52.
H. alaschanicus coreensis: Jo et al. 2012 p.251.
Range: Hypsugo alaschanicus ranges throughout the Korean Peninsula and Jeju Island (Yoon 2010; Jo et al. 2012; Fig. 38).
Remarks: Populations in Korea were recognized as the species Hypsugo coreensis (Imaizumi, 1955) (Yoon 2010). Although Yoshiyuki (1989) and Yoon (2010) treated coreensis as a distinct species, Pipistrellus coreensis or Hypsugo coreensis, respectively, Horácek et al. (2000) proposed that coreensis may represent a separate subspecies of H. alaschanicus instead of a distinct species. Although the geographic range of H. a. velox (Vladivostok, eastern Siberia, Hokkaido and Honshu) lies closer to H. a. coreensis (with which it shares similar habitats), the two subspecies have morphological differences in features of the braincase, teeth and color (Yoshiyuki 1989). H. a. coreensis has a larger braincase, more developed antero-internal cusp of P 4, and more reddish dorsal color than H. a. velox (Yoon 2010). On molecular grounds, Hypsugo savii in western Eurasia and H. alaschanicus in eastern Eurasia show a clear phylogeographic split (Datzmann et al. 2012). We followed Horácek et al. (2000) in listing this species.
Conservation status: The North Korean Government classified this species as ‘Rare’ (MAB National Committee of DPR Korea 2002).
description: Published as part of Jo, Yeong-Seok, Baccus, John T. & Koprowski, John L., 2018, Mammals of Korea: a review of their taxonomy, distribution and conservation status, pp. 1-216 in Zootaxa 4522 (1) on page 61, DOI: 10.11646/zootaxa.4522.1.1, http://zenodo.org/record/2610198
Atopopompilus jacens
Creators: name: Gadallah, Neveen S.
name: Schmid-Egger, Christian
name: Brothers, Denis J.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Pompilidae
Atopopompilus
Atopopompilus jacens

description: Atopopompilus jacens (Bingham, 1912)
Distribution in the Arabian Peninsula: Yemen (Wahis 2000a).
Extralimital distribution: Distributed throughout Tropical Africa (Day 1974).
description: Published as part of Gadallah, Neveen S., Schmid-Egger, Christian & Brothers, Denis J., 2020, Biodiversity of the aculeate wasps (Hymenoptera: Aculeata) of the Arabian Peninsula: Vespoidea, Pompilidae, pp. 153-173 in Zootaxa 4754 (1) on page 161, DOI: 10.11646/zootaxa.4754.1.16, http://zenodo.org/record/3719039
Miniopteridae Dobson 1875
Creators: name: Jo, Yeong-Seok
name: Baccus, John T.
name: Koprowski, John L.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Miniopteridae

description: Family MINIOPTERIDAE Dobson, 1875
Despite support for full familial status based on morphological data (Aggarwal & Sinha 1973; Mein & Tupinier 1977), this taxon has long been classified in the Subfamily Miniopterinae in the Family Vespertilionidae (Simmons 2005). Hoofer and Van Den Bussche (2003) and Miller-Butterworth et al. (2007) later elevated Miniopteridae to a distinct family based on molecular analysis, a distinction that has been confirmed through subsequent DNA-based studies (Lack & Van Den Bussche 2010; Lack et al. 2010).
description: Published as part of Jo, Yeong-Seok, Baccus, John T. & Koprowski, John L., 2018, Mammals of Korea: a review of their taxonomy, distribution and conservation status, pp. 1-216 in Zootaxa 4522 (1) on page 61, DOI: 10.11646/zootaxa.4522.1.1, http://zenodo.org/record/2610198
U.S. physicians treatment of adolescent tobacco use
Creators: name: Niemczyk-Kistner, Kristen Caroline
Publisher: name: No Publisher Supplied
Year: 2014

description: Smoking initiation typically occurs in adolescence and increase over time into emerging adulthood. According to the 2012 Report of the Surgeon General, of every three young smokers, only one will quit, and one of those remaining smokers will die from tobacco-related causes (U.S. Department of Health and Human Services, 2012). Thus, adolescence and emerging adulthood compose a critical time period for prevention and intervention efforts. The current study provides a description of physicians’ provision of smoking cessation treatment to adolescents in the United States, examines physician compliance with the U.S. Public Health Service (PHS) guidelines, through secondary analyses of nationally representative data on physician patient encounters during ambulatory care visits. In this case control study, I utilized data from the National Ambulatory Medical Care Survey (NAMCS) collected by the National Center for Health Statistics (NCHS) of the Centers for Disease Control and Prevention (CDC).    The major findings from this study include the following: physician compliance with the PHS guidelines is suboptimal. Specifically, the results indicated that physicians fell short on the standard outlined in the PHS guidelines. Furthermore, when examining physicians provision of education/advice to the entire study population, regardless of smoking status, it was found that physicians were more likely to provide education/advice to current smokers than to non-smokers; those listed as “Other” for racial background than Whites or African-Americans; those ages 14-15 and 16-1& than those ages 12-13; and those that had a preventive care visit. Finally, when examining the care provision of adolescents using tobacco, it was found that physicians provided education/counseling to 25% of adolescents using tobacco. The results found serve to support earlier literature, while this current study also provided a large set of new findings relating to tobacco use and treatment. Overall, the findings in this study suggest that physician compliance with the PHS guidelines is suboptimal. As a result, this is an opportunity for social workers to assist physicians with counseling efforts, as well as implement policy change.
MOESM2 of Active fraction (HS7) from Taiwanofungus camphoratus inhibits AKT-mTOR, ERK and STAT3 pathways and induces CDK inhibitors in CL1-0 human lung cancer cells
Creators: name: I-Chun Lai
name: Gi-Ming Lai
name: Jyh-Ming Chow
name: Hsin-Lun Lee
name: Yeh, Chuan-Feng
name: Chi-Han Li
name: Jiann-Long Yan
name: Shuang-En Chuang
name: Whang-Peng, Jacqueline
name: Kuan-Jen Bai
name: Chih-Jung Yao
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2. Minimum standards of reporting checklist-R.
Miniopterus Bonaparte 1837
Creators: name: Jo, Yeong-Seok
name: Baccus, John T.
name: Koprowski, John L.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Chiroptera
Miniopteridae
Miniopterus

description: Genus Miniopterus Bonaparte, 1837
Miniopterus, a single genus in the Family Miniopteridae, has two species recorded in Korea. Since M. fuscus occurred only once at the southeastern tip of Korea, we consider the species as a vagrant from Japan (see below).
description: Published as part of Jo, Yeong-Seok, Baccus, John T. & Koprowski, John L., 2018, Mammals of Korea: a review of their taxonomy, distribution and conservation status, pp. 1-216 in Zootaxa 4522 (1) on page 62, DOI: 10.11646/zootaxa.4522.1.1, http://zenodo.org/record/2610198
Batozonellus unifasciatus
Creators: name: Gadallah, Neveen S.
name: Schmid-Egger, Christian
name: Brothers, Denis J.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Pompilidae
Batozonellus
Batozonellus unifasciatus

description: Batozonellus unifasciatus (Smith, 1855)
Distribution in the Arabian Peninsula: Saudi Arabia (Abu Zoherah et al. 1993 as Pompilus unifasciatus). Extralimital distribution: China, India, Indonesia (Junco y Reyes 1963).
description: Published as part of Gadallah, Neveen S., Schmid-Egger, Christian & Brothers, Denis J., 2020, Biodiversity of the aculeate wasps (Hymenoptera: Aculeata) of the Arabian Peninsula: Vespoidea, Pompilidae, pp. 153-173 in Zootaxa 4754 (1) on page 161, DOI: 10.11646/zootaxa.4754.1.16, http://zenodo.org/record/3719039
Two applications of combinatorial optimization
Creators: name: Oster, Matthew R.
Publisher: name: No Publisher Supplied
Year: 2014

description: This thesis presents two applications of combinatorial optimization. The first part contains a detailed description of a conference scheduling problem. We model the problem as a symmetric clustering problem, or a variant of minimum k-partition we call capacitated k-partition. This problem is proved to be NP-hard to solve to optimality, and further, unless P = NP, no constant factor polynomial-time approximation algorithm exists. We also propose a branch-and-cut algorithm with semidefinite programming relaxations enhanced with polyhedral cuts found at each tree node. Many cutting planes are demonstrated to be satisfied, or provably close to being satisfied, by semidefinite matrices in the variable space [−1/(k − 1), 1], which is in contrast to basic linear programming relaxations. Our algorithm also relies on a novel heuristic strategy when attempting to generate feasible solutions at every tree node. We test an implementation of our algorithm on random k-partition instances as well as a particular conference data set which comes from the 13th Annual INFORMS Computing Society Conference and was solved to within 0.85% of optimum in under 4 hours. The results here are promising and provide a starting point for future projects.    In the second part, we describe a project called the Boat Allocation Module, where a team comprised of United States Coast Guard (USCG) analysts, and Command, Control, and Interoperability Center for Advanced Data Analysis researchers worked together in building a decision support system for USCG analysts. The software was designed to solve the problem of allocating boats of the Coast Guard to the nation’s coastal stations, so as to meet station requirements, while adhering to particular budget and capability limitations. We model the problem as a resource allocation problem and prove that it is NP-hard to solve. We relax the problem slightly by allowing a single boat type to be shared, or assigned among disjoint subsets of stations rather than to individual stations, but show that implementing “seasonal” sharing is NP-hard. A mixed integer linear programming formulation is proposed, and an implementation within a decision support system for USCG analysts is tested as per USCG Verification and Validation standards. The software provides an intuitive interface and allows for a variety of scenarios. Tests have shown that our tool may save the Coast Guard millions of dollars a year.
Parablepharis Saussure 1870
Creators: name: Schwarz, Christian J.
name: Konopik, Oliver
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Mantodea
Hymenopodidae
Parablepharis

description: Parablepharis Saussure, 1870
A monotypic SE Asian genus with a rather unstable systematic history (see discussion in Roy 2008). Two subspecies are currently recognized; the nominate subspecies occurs in Borneo. They are arboricolous and rarely collected.
Parablepharis kuhlii kuhlii (De Haan, 1842) §
Mantis (Blepharis) kuhlii De Haan, 1842
Distribution. Java, Borneo (Werner 1933, Roy 2008).
Bornean records. Sarawak: Mt. Matang (Giglio-Tos 1915a); Sabah: N Sabah (AFUW).
Subfam. Acromantinae Brunner von Wattenwyl, 1893 1
description: Published as part of Schwarz, Christian J. & Konopik, Oliver, 2014, An annotated checklist of the praYing mantises (Mantodea) of Borneo, including the results of the 2008 scientific expedition to Lanjak Entimau Wildlife SanctuarY, Sarawak, pp. 130-168 in Zootaxa 3797 (1) on page 139, DOI: 10.11646/zootaxa.3797.1.12, http://zenodo.org/record/226038
Macro and micro characterization of powder mixing processes
Creators: name: Osorio Caicedo, Juan Guillermo
Publisher: name: No Publisher Supplied
Year: 2014

description: Powder mixing is a critical operation in pharmaceuticals and other industries. Despite much research, there is still a lack of understanding of the mixing mechanisms, their effects on blend properties, and how these affect the quality of the final product. In addition, commonly used and new batch mixing technologies are not well established to handle the growing number of products involving cohesive and highly potent active pharmaceutical ingredients (APIs).    The work presented in this dissertation focuses on the macro- and micro-mixing characterization of a resonant acoustic mixer (RAM), and the micro-mixing dynamic characterization of bin-blending for pharmaceutical powders, with an emphasis on mixing cohesive APIs. First, the mixing performance of the RAM as a function of processing parameters (acceleration, fill level and blending time) was characterized. Then the effects of the RAM processing parameters on the final blend properties, and tableting and tablet characteristics were investigated. This was followed by the micro-mixing characterization of blends obtained from the RAM using near-infrared chemical imaging (NIR-CI). In the second part of this dissertation, the micro-mixing dynamics of three APIs, chlorpheniramine maleate (very cohesive), acetaminophen (cohesive) and caffeine (slightly cohesive), were characterized using in situ NIR-CI and compared.     Overall, blends in the RAM reached the required blend uniformity (RSD < 5%) in as low as 30 seconds. Resonant acoustic mixing significantly affected the final properties of lubricated blends, increasing their density with increases in acceleration and blending time. These changes in blend properties affected the final properties of tablets by increasing weight, decreasing hardness, and decreasing dissolution. All blend and tablet properties, except hydrophobicity, followed a power law when correlated to the energy per unit mass. The aggregation of the API in the blends decreased with increasing mixing intensity (acceleration) and blending time. In the bin-blending studies, the most cohesive API followed the expected trends (e.g. higher RSDs and larger aggregate sizes), while the trends for APAP and caffeine were dependent on their concentrations. NIR-CI was useful in monitoring the distribution and aggregate size of APIs and excipients, demonstrating agglomeration as a function of cohesion and API concentration in the blends.