cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: ADCO, Boursier de Cîteaux : comptes (1489-1493) (11 H 1166), f. 00423
Creators: name: de la Côte-d'Or, Archives départementales
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: comptes

description: Boursier de Cîteaux : comptes (1489-1493), Archives départementales de la Côte-d'Or, (11 H 1166). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Boursier de Cîteaux : comptes (1489-1493), Archives départementales de la Côte-d'Or, (11 H 1166), f. 00423, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
TOWARDS MORE SUSTAINABLE SOIL FERTILITY MANAGEMENT
Creators: name: Dofoer, Toon
name: Kante, Salif
name: Hilhorst, Thea
name: Groote, Hugo
name: Dofoer, Toon
name: Kante, Salif
name: Hilhorst, Thea
name: Groote, Hugo
Publisher: name: Unknown
Year: 1996
Subjects: Environmental Economics and Policy
Resource /Energy Economics and Policy

description: In southern Mali, more intensive soil fertility management strategies are needed to guarantee sustainableproduction. However, the increasing I iversity of the farming systems places high demands on research and extension. Technologies pmposed as recipes for the average fI rmer are becoming less and less relevant. The Farming Systems Research team (ESPGRN) o f the Agricultural Research Institute (IER) nI is developing an action-research approach to enII' farmers, together with researchers, to I nalyse and understand farmer strategies and practices of soil fertty management and to iI- ntify technologies which both meet farmers' needs and are sustainable. The analysis is done at the village andfarm levels, using different participatory tools. First a village territory map is made to analyse the mI nagement of the natural resources in the villI.'. Next, the diversity of soil fertility mI nagement practices between farms is investigated and its underlying causes are diagnosed. A classification o f farms is made by the villagers using their own criteria for distinguishing levels of fertility management. Subsequently, the actual management practices I- depicted pictorially using resource flow models, drawn by 'test' farmers, representing each of the different categories o f farms. On the II sis of these models, farmers and researchers I iscuss various possibilities for increasing the recycling of crop residues and reducing losses from their farms, and flow models are made to DI n management practices for the subsequent year. The combination of analysis and regular feedback of farmers' results, together with exposure to information on new technologies, motivates farmers to plan their own activities. If farmers so request, a field worker assists them to implement the new techniques. Village intermediaries are also being trained in mapping techniques and practical aspects of the new technologies. There are clear indications that this approach has improved soil fertility management practices. Farmers have started to recycle considerable amounts of crop residues as litter and fodder. They are also experimenting with contour farming and planting fodder crops in association with cereals.
Echinacea purpurea Moench 1794
Creators: name: Jarvis, Charlie
Publisher: name: Linnaean Society of London in association with the Natural History Museum
Year: 2007
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Asterales
Asteraceae
Echinacea
Echinacea purpurea

description: Rudbeckia purpurea Linnaeus, Species Plantarum 2: 907. 1753, nom. cons.
"Habitat in Virginia, Carolina." RCN: 6553.
Conserved type (Binns & al. in Taxon 50: 1199. 2002 [2001]): U.S.A. Arkansas, " Echinacea serotina Arkansa ", Nuttall, s.n. (BM-000541360).
Current name: Echinacea purpurea (L.) Moench (Asteraceae).
description: Published as part of Jarvis, Charlie, 2007, Chapter 7: Linnaean Plant Names and their Types (part R), pp. 785-805 in Order out of Chaos. Linnaean Plant Types and their Types, London :Linnaean Society of London in association with the Natural History Museum on page 802, DOI: 10.5281/zenodo.291971
Cell and extracellular matrix interactions: a biomimetic approach to use cryptic extracellular information to regulate the epithelial-to-mesenchymal transition
Creators: name: Wang, Alex
Publisher: name: Imperial College London
Year: 2015

description: The extracellular matrix (ECM) provides dynamic biochemical and structural cues that control cell proliferation, signalling, and homeostasis. A critical feature of the ECM is its cryptic sites, hidden biologically active sites exposed through structural alteration or proteolytic cleavage events. In this project, a cryptic signalling fragment derived from the laminin-111 protein is explored as a potential control switch for the epithelial-to- mesenchymal transition (EMT), a critical process in development, wound healing, and cancer progression. One EMT-related pathology in wound healing is fibrosis, the accumulation of excess scar tissue that inhibits normal tissue function. A potential strategy in treating this disease is to control or slow the EMT process during wound healing to prevent epithelial cells from transforming into myofibroblasts that contribute to fibrotic tissue. The effect of the cryptic fragment is characterised in Mus musculus mammary gland epithelial cells (NMuMGs) undergoing transforming growth factor β (TGFβ) induced EMT using imaging, biochemical, and molecular-biological techniques. The fragment is then used to engineer a biomimetic basement membrane (BM), using polydopamine coated poly(ε- caprolactone) as the structural scaffold. This system allows stable binding of proteins, as well as providing a suitable surface for epithelial cell proliferation. In this work it is shown that the cryptic fragment directly down-regulates crucial EMT genes in this artificial BM system in NMuMGs, providing a potential reduction of fibrosis pathology. Future and ongoing work will continue to optimise the system and lead to other applications of EMT control both for in vivo and in vitro studies. This project explores the still widely unused potential of cryptic ECM information in tissue engineering.
Additional file 1: of Differential genetic responses to the stress revealed the mutation-order adaptive divergence between two sympatric ginger species
Creators: name: Huang, Bing-Hong
name: Yuan-Chien Lin
name: Huang, Chih-Wei
name: Hsin-Pei Lu
name: Min-Xin Luo
name: Pei-Chun Liao
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology

description: Sequencing depth of coverage across pseudo-reference genome. (DOCX 653 kb)
Quantifying the Morphologies and Dynamical Evolution of Galaxy Clusters. II. Application to a Sample of ROSAT Clusters
Creators: name: Buote, David A.
name: Tsai, John C.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We quantify the morphologies and dynamical states of 59 galaxy clusters using the power-ratio technique of Buote & Tsai applied to ROSAT PSPC X-ray images. The clusters exhibit a particularly strong $P_2/P_0 - P_4/P_0$ correlation in the $1h^{-1}_{80}$ Mpc aperture which may be interpreted as an evolutionary track; the location of a cluster on the correlation line indicates the dynamical state of the cluster and the distribution of clusters along this track measures the rate of formation and evolution of clusters in our sample. The power ratios anti-correlate with the cooling-flow rate indicating a reasonable dependence of the flow rate on cluster morphology. The relationship of the power ratios to the optical Bautz-Morgan (BM) Type is more complex. This is because the power ratios are sensitive to unrelaxed regions of clusters within a specified scale, whereas BM types are sensitive to unrelaxed regions over many scales. We discuss further astrophysical applications exploiting the relationship between the power ratios and the evolutionary states of clusters.
description: 31 pages (8 figures), PostScript, to appear in ApJ on February 10, 1996. In this version we added four more clusters to our sample and revised the error estimates for the power ratios (and the corresponding figures)
Steinberg's tensor product theorem and exceptional groups
Creators: name: Abiteboul, Manon
Publisher: name: Imperial College London
Year: 2015

description: Let $X$ be a simple, simply connected algebraic group over an algebraically closed field $k$ of characteristic $p$. Steinberg's tensor product theorem states that if $V$ is a finite dimensional irreducible $kX$-module then $V$ = $V_1 ^{(q_1)} \otimes \ldots \otimes V_n ^{(q_n)}$ where each $V_i$ is a restricted $kX$-module and the $q_i$ are distinct powers of $p$. This theorem can be reformulated in terms of rational representations instead of modules as follows: any irreducible rational representation $\Phi : X \rightarrow SL(V)$ can be factorised as $\Phi : X \xrightarrow{\text{$\Psi$}} X \times X \times \ldots \times X \xrightarrow{\text{$\mu$}} SL(V)$ with $\Psi : x \rightarrow (x^{(q_1)} , \ldots , x^{(q_j)})$ where $x^{(q_i)}$ denotes the image of $x$ under the standard Frobenius $q_i$ map and $\mu$ restricts to a completely reducible restricted representation on each factor. Liebeck and Seitz proved a generalisation of this theorem where the target group $SL(V)$ is replaced by an arbitrary simple algebraic group $G$ over $k$ in good characteristic. A consequence of this theorem is that every connected simple $G$-completely reducible ($G$-cr) subgroup $X$ of $G$ is contained in a uniquely determined commuting product $R_1 \ldots R_n$ in $G$ such that each $R_i$ is a simple restricted subgroup of the same type as $X$ and each projection $X \rightarrow R_i / Z(R_i)$ is non trivial and involves a different field twist. Here saying that $X$ is $G$-cr means that whenever $X$ is contained in a parabolic subgroup $P$ of $G$, it is contained in a Levi subgroup of $P$. The first new theorem of this thesis is a converse of this result: if $G$ is of exceptional type in good characteristic and $X$ is contained in such a product $R_1 \ldots R_n$, then $X$ is $G$-cr, with two exceptions. If $G$ is of classical type we prove a similar theorem with the extra assumption that the $R_i$ are $G$-cr. In view of these results, it is of interest to determine the products $R_1 \ldots R_n$ of more than one restricted subgroup of the same type in exceptional algebraic groups; this is achieved in the rest of this thesis. The above results have a number of consequences. First, every restricted connected simple subgroup of $G$ is $G$-cr with two exceptions. We also classify all non-restricted $G$-cr simple subgroups of exceptional groups. We find the centralisers of all products of more than one subgroup of the same type and of all non-restricted $G$-cr simple subgroups. We also prove that the conjugacy classes of such subgroups are uniquely determined by the restriction of the Lie algebra of $G$.
Massively parallel fabrication of crack-defined gold break junctions featuring sub-3 nm gaps for molecular devices
Creators: name: Dubois, Valentin
name: Raja, Shyamprasad N.
name: Gehring, Pascal
name: Caneva, Sabina
name: van der Zant, Herre S. J.
name: Niklaus, Frank
name: Stemme, Göran
Publisher: name: arXiv
Year: 2018
Subjects: subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: Break junctions provide tip-shaped contact electrodes that are fundamental components of nano and molecular electronics. However, the fabrication of break junctions remains notoriously time-consuming and difficult to parallelize. Here we demonstrate true parallel fabrication of gold break junctions featuring sub-3 nm gaps on the wafer-scale, by relying on a novel self-breaking mechanism based on controlled crack formation in notched bridge structures. We achieve fabrication densities as high as 7 million junctions per cm$^{2}$, with fabrication yields of around 7% for obtaining crack-defined break junctions with sub-3 nm gaps of fixed gap width that exhibit electron tunneling. We also form molecular junctions using dithiol-terminated oligo(phenylene ethynylene) (OPE3) to demonstrate the feasibility of our approach for electrical probing of molecules down to liquid helium temperatures. Our technology opens a whole new range of experimental opportunities for nano and molecular electronics applications, by enabling very large-scale fabrication of solid-state break junctions.
description: includes supporting information, 7 Figures in main text, 7 Figures in supporting information, compilation of images in supporting information
title: A fight for health: my transgender journey for care.
Creators: name: Inman, Aly
Publisher: name: Memorial University of Newofundland
Year: 2020

description: This critical autoethnographic study chronicles my personal journey accessing health care as a transgender person. Access to health care is a current issue for transgender people in Canada, particularly in Canada’s smallest province, Prince Edward Island. This research addresses geographical and methodological gaps in the current literature by providing a rich and detailed description of my health care journey as a member of Prince Edward Island’s transgender community. This insider account intends to improve understanding, increase awareness, and facilitate meaningful health system and societal change. Personal memory data, self-observation/self-reflection data, and external data sets including my medical records, surgery denial forms, Facebook conversations, and personal emails were collected. Thematic analysis was conducted using a queer theory lens and revealed four major themes: ill health and personal transformation, privacy and safety, barriers and facilitators to care, and an ideal system and hope for the future. Four recommendations were generated: the need for a gender-affirming health care policy, better pathways to access medical transition related health care services, education and training for Prince Edward Island health care professionals, and an online information hub.
GRB afterglows: from ultra-relativistic to non-relativistic phase
Creators: name: Huang, Y. F.
name: Dai, Z. G.
name: Lu, T.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Postburst evolution of adiabatic fireballs that produce $γ$-ray bursts is studied. Emphasis has been put on the transition from the highly relativistic phase to the non-relativistic phase, which, according to our calculation, should happen much earlier than previously expected. The theoretical light curves decline a little sharper at the non-relativistic stage than at early times, but still can fit the observations well. However, disagreements are obvious when $t \ge 100$ d, implying a large initial energy $E_0$, a low interstellar density $n$, or the possible existence of a persistent energy source at the center of the fireball.
description: 4 pages, latex file(l-aa style), 5 figures, A&A letter accepted
Rudbeckia triloba var. triloba Linnaeus 1753
Creators: name: Jarvis, Charlie
Publisher: name: Linnaean Society of London in association with the Natural History Museum
Year: 2007
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Asterales
Asteraceae
Rudbeckia
Rudbeckia triloba
Rudbeckia triloba l. var. triloba

description: Rudbeckia triloba Linnaeus, Species Plantarum 2: 907. 1753.
"Habitat in Virginia." RCN: 6551.
Type not designated.
Original material: Herb. Linn. No. 74 (SBT); Clayton 657 (BM); [icon] in Plukenet, Phytographia: t. 22, f. 2. 1691; Almag. Bot.: 100. 1696.
Current name: Rudbeckia triloba L. var. triloba (Asteraceae).
description: Published as part of Jarvis, Charlie, 2007, Chapter 7: Linnaean Plant Names and their Types (part R), pp. 785-805 in Order out of Chaos. Linnaean Plant Types and their Types, London :Linnaean Society of London in association with the Natural History Museum on page 802, DOI: 10.5281/zenodo.291971
Radion-Higgs Mixing in 2HDMs
Creators: name: Merchand, Marco
name: Sher, Marc
name: Thrasher, Keith
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the custodial Randall-Sundrum model with two Higgs doublets localized in the $\TeV $ brane. The scalar potential is CP- conserving and has a softly broken $Z_2$ symmetry. In the presence of a curvature-scalar mixing term $ ξ_{ab} \mathcal{R} Φ_a^\dagger Φ_b$ the radion that stabilizes the extra dimension now mixes with the two CP-even neutral scalars $h$ and $H$. A goodness of fit of the LHC data on the properties of the light Higgs is performed on the parameter space of the type-I and type-II models. LHC direct searches for heavy scalars in different decay channels can help distinguish between the radion and a heavy Higgs. The most important signatures involve the ratio of heavy scalar decays into $b$ quark pairs to those into $Z$ pairs, as well as the decay of the scalar (pseudoscalar) into a $Z$ plus a pseudoscalar (scalar).
description: 31 pages, 27 figures. Version to be published in JHEP
The distribution and physical properties of high-redshift [OIII] emitters in a cosmological hydrodynamics simulation
Creators: name: Moriwaki, Kana
name: Yoshida, Naoki
name: Shimizu, Ikkoh
name: Harikane, Yuichi
name: Matsuda, Yuichi
name: Matsuo, Hiroshi
name: Hashimoto, Takuya
name: Inoue, Akio K.
name: Tamura, Yoichi
name: Nagao, Tohru
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Recent observations with the Atacama Large Millimeter/submillimeter Array (ALMA) detected far-infrared emission lines such as the [OIII] 88 μm line from galaxies at $z \sim 7 - 9$. Far-infrared lines can be used to probe the structure and kinematics of such high-redshift galaxies as well as to accurately determine their spectroscopic redshifts. We use a cosmological simulation of galaxy formation to study the physical properties of [OIII] 88 μm emitters. In a comoving volume of 50 $h^{-1}$ Mpc on a side, we locate 34 galaxies with stellar masses greater than $10^8\ {\rm M_\odot}$ at $z = 9$, and more than 270 such galaxies at $z = 7$. We calculate the [OIII] 88 μm luminosities ($L_{\rm OIII}$) by combining a physical model of HII regions with emission line calculations using the photoionization code CLOUDY. We show that the resulting $L_{\rm OIII}$, for a given star formation rate, is slightly higher than predicted from the empirical relation for local galaxies, and is consistent with recent observations of galaxies at redshifts 7 - 9. Bright [OIII] emitters with $L_{\rm OIII} > 10^8 {\rm L_\odot}$ have stellar masses greater than $10^9\ {\rm M_\odot}$, star formation rates higher than $3\ {\rm M_\odot\ yr}^{-1}$, and the typical metallicity is $\sim 0.1\ {\rm Z_\odot}$. The galaxies are hosted by dark matter halos with masses greater than $10^{10.5}\ {\rm M_\odot}$. Massive galaxies show characteristic structure where the [OIII] emitting gas largely overlaps with young stars, but the emission peak is separated from the main stellar population, suggesting the stochastic and localized nature of star formation in the first galaxies. We propose to use the [OIII] 5007 Å line, to be detected by James Webb Space Telescope (JWST), to study the properties of galaxies whose [OIII] 88 μm line emission has been already detected with ALMA.
description: 5 pages, 4 figures. Accepted for publication in MN Letters
Additional file 6: of Minimally invasive anterior muscle-sparing versus a transgluteal approach for hemiarthroplasty in femoral neck fractures-a prospective randomised controlled trial including 190 elderly patients
Creators: name: Saxer, Franziska
name: Studer, Patrick
name: Jakob, Marcel
name: Suhm, Norbert
name: Rosenthal, Rachel
name: Dell-Kuster, Salome
name: Vach, Werner
name: Bless, Nicolas
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Table S2. Association of patient characteristics and availability of the primary outcome. Association of patient characteristics and previous measurements with non-attendance at follow-up visits, non-availability of DTP or non-performance of TUG when attending. The observed ORs in each treatment arm, the p-value of an overall effect of the variable (p1), and the p-value of a test for equality across the two arms (p2) are given. For continuous variables, the OR refers to changing this variable by one standard deviation. (DOCX 13 kb)
Fairness Under Composition
Creators: name: Dwork, Cynthia
name: Ilvento, Christina
Publisher: name: arXiv
Year: 2018
Subjects: subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: Algorithmic fairness, and in particular the fairness of scoring and classification algorithms, has become a topic of increasing social concern and has recently witnessed an explosion of research in theoretical computer science, machine learning, statistics, the social sciences, and law. Much of the literature considers the case of a single classifier (or scoring function) used once, in isolation. In this work, we initiate the study of the fairness properties of systems composed of algorithms that are fair in isolation; that is, we study fairness under composition. We identify pitfalls of naive composition and give general constructions for fair composition, demonstrating both that classifiers that are fair in isolation do not necessarily compose into fair systems and also that seemingly unfair components may be carefully combined to construct fair systems. We focus primarily on the individual fairness setting proposed in [Dwork, Hardt, Pitassi, Reingold, Zemel, 2011], but also extend our results to a large class of group fairness definitions popular in the recent literature, exhibiting several cases in which group fairness definitions give misleading signals under composition.
description: Fixed two word omissions
title: The strongest predictors of length of stay and prosthetic fitting for people with lower limb amputations.
Creators: name: Chislett, Michael
Publisher: name: Memorial University of Newofundland
Year: 2020

description: Title: The Strongest Predictors of Length of Stay and Prosthetic Fitting for People with Lower Limb Amputations. Objective: To identify the strongest predictors of rehabilitation length of stay and prosthetic fitting success for lower limb amputees. Design: Retrospective analysis of clinically collected cohort. Setting: Canadian inpatient rehabilitation facility. Participants: Consecutive lower limb amputees admitted for prosthetic fitting from 2010-2017 (N = 103; mean age 65.3 ± 10.6 years). Interventions: Not applicable. Main Outcome Measures: Predictor variables included the Lower Limb Amputee Measurement Scale (LLAMS), which is a 31-question tool to predict length of stay with indicators in medical, cognitive, social, physical, activities of daily living, and other subsections; admission Functional Independence Measure (FIM®); level of amputation (below-knee or above-knee); age; sex; and time from surgery to admission. Length of stay was measured as days from admission to discharge. Successful prosthetic fitting was defined as ability to use a prosthesis on discharge. Results: The mean length of stay was 63.6 (± 33.3) days and 21.4% of patients failed prosthetic fitting. Higher LLAMS, lower FIM®, and above-knee amputation significantly predicted longer length of stay (p < 0.001, R² = 0.36). Age, sex, and time from surgery did not significantly predict length of stay or prosthetic fitting. Higher LLAMS significantly (p = 0.032) predicted unsuccessful prosthetic fitting. A revised LLAMS, including the strongest predictors of length of stay increased the R² of the model from 0.36 to 0.51. A revised LLAMS, including the strongest predictors of prosthetic fitting increased the R² of the model from 0.15 to 0.32. Conclusions: The LLAMS, admission FIM®, and level of amputation can be used to predict length of stay in people with lower limb amputations admitted for prosthetic fitting. Within the LLAMS, history of cognitive impairment/psychiatric illness, clinical judgement, and living alone were the strongest predictors of increased length of stay. Functional tasks and skin condition indicators were the strongest predictors of successful fitting. Shortening the tool to five items increased the predictive ability of the LLAMS.
Lindernia antipoda Alston 1931
Creators: name: Jarvis, Charlie
Publisher: name: Linnaean Society of London in association with the Natural History Museum
Year: 2007
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Lamiales
Linderniaceae
Lindernia
Lindernia antipoda

description: Ruellia antipoda Linnaeus, Species Plantarum 2: 635. 1753.
"Habitat in Indiis." RCN: 4617.
Lectotype (Philcox in Kew Bull. 17: 482. 1964): Herb. Hermann 2: 9, No. 235, upper specimen (BM-000621524).
Current name: Lindernia antipoda (L.) Alston (Scrophulariaceae).
description: Published as part of Jarvis, Charlie, 2007, Chapter 7: Linnaean Plant Names and their Types (part R), pp. 785-805 in Order out of Chaos. Linnaean Plant Types and their Types, London :Linnaean Society of London in association with the Natural History Museum on page 802, DOI: 10.5281/zenodo.291971
The role of interferon in the development of pulmonary arterial hypertension
Creators: name: George, Peter Michael
Publisher: name: Imperial College London
Year: 2014

description: Interferons (IFNs) are an integral part of the innate immune response to viral infection. As well as possessing important anti-viral properties, they possess immunomodulatory, cytotoxic and anti-tumoural functions. As a consequence, the IFNs (mainly type I IFN) have been utilised for the treatment of human disease where they represent important therapies, most commonly in the treatment of chronic hepatitis C virus (HCV). However, there is now emerging evidence of an association between type I IFN drug treatment and the development of severe and at times irreversible pulmonary arterial hypertension (PAH). Through the course of this PhD I have investigated potential mechanisms for type I IFN induced PAH and have identified the IFN regulated protein IP10 and the promitogen and vasoconstrictor endothelin (ET)-1 as important candidate mediators. It is well established that autoimmune conditions such as systemic sclerosis, where PAH is a common complication, are typified by chronic activation of type I IFN pathways. I have used the observation that IFN drug treatment may cause PAH, as a platform to hypothesise that endogenous type I IFN production may be important in the pathogenesis of systemic sclerosis associated PAH. Through a comprehensive approach utilising in vitro cell culture models, in vivo animal models of disease and patient samples, I have demonstrated that endogenously produced type I IFN plays an important role in the development of systemic sclerosis associated PAH and also idiopathic PAH. I have also gone on to show that other facets of the immune system appear to have pathogenic relevance in this devastating and still under-characterised disease. I conclude that a dysregulated and chronically active innate immune system plays a pathological role in the development of pulmonary arterial hypertension.
Supplementary document for Two-photon absorption flexible photodetector responsive to femtosecond laser - 6828598.pdf
Creators: name: Xu, Yanming
name: Wang, Fan
name: Xu, Jinlong
name: Lv, Xinjie
name: Zhao, Gang
name: Sun, Zhihua
name: Xie, Zhenda
name: Zhu, Shining
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: Supplement 1
An uncertainty principle for star formation - II. A new method for characterising the cloud-scale physics of star formation and feedback across cosmic history
Creators: name: Kruijssen, J. M. Diederik
name: Schruba, Andreas
name: Hygate, Alexander P. S.
name: Hu, Chia-Yu
name: Haydon, Daniel T.
name: Longmore, Steven N.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: The cloud-scale physics of star formation and feedback represent the main uncertainty in galaxy formation studies. Progress is hampered by the limited empirical constraints outside the restricted environment of the Local Group. In particular, the poorly-quantified time evolution of the molecular cloud lifecycle, star formation, and feedback obstructs robust predictions on the scales smaller than the disc scale height that are resolved in modern galaxy formation simulations. We present a new statistical method to derive the evolutionary timeline of molecular clouds and star-forming regions. By quantifying the excess or deficit of the gas-to-stellar flux ratio around peaks of gas or star formation tracer emission, we directly measure the relative rarity of these peaks, which allows us to derive their lifetimes. We present a step-by-step, quantitative description of the method and demonstrate its practical application. The method's accuracy is tested in nearly 300 experiments using simulated galaxy maps, showing that it is capable of constraining the molecular cloud lifetime and feedback time-scale to $<0.1$ dex precision. Access to the evolutionary timeline provides a variety of additional physical quantities, such as the cloud-scale star formation efficiency, the feedback outflow velocity, the mass loading factor, and the feedback energy or momentum coupling efficiencies to the ambient medium. We show that the results are robust for a wide variety of gas and star formation tracers, spatial resolutions, galaxy inclinations, and galaxy sizes. Finally, we demonstrate that our method can be applied out to high redshift ($z\lesssim4$) with a feasible time investment on current large-scale observatories. This is a major shift from previous studies that constrained the physics of star formation and feedback in the immediate vicinity of the Sun.
description: 86 pages (including appendices), 30 figures, 16 tables; accepted by MNRAS (April 27, 2018). The method is summarised in Figure 2 and 3, with the main results shown in Figures 18, 26, and 27. For a cursory overview of the paper (of about 10 pages), please consult Sections 1, 2, 3.1, 4.4, 6, and 8. Figure 27 replaced with authors' original version
THE OPTIMAL N-BODY METHOD FOR STABILITY STUDIES OF GALAXIES
Creators: name: Earn, David J. D.
name: Sellwood, J. A.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The stability of a galaxy model is most easily assessed through N-body simulation. Particle-mesh codes have been widely used for this purpose, since they enable the largest numbers of particles to be employed. We show that the functional expansion technique, originally proposed by Clutton-Brock for other simulation problems, is in fact superior for stability work. For simulations of linear evolution it is not much slower than grid methods using the same number of particles, and reproduces analytical results with much greater accuracy. This success rests on its ability to represent global modes with a modest number of basis functions; grid methods may be more effective for other applications, however. Our conclusions are based on implementations of functional expansion and grid algorithms for disk galaxies.
description: Accepted for publication in The Astrophysical Journal, to appear October 1, 1995; 16 pages including 4 figures, self-unpacking uuencoded gzipped postscript, also available by email from earn@astro.huji.ac.il
Ultrasonic inspection of highly scattering materials
Creators: name: Van Pamel, Anton
Publisher: name: Imperial College London
Year: 2015

description: Ultrasonic Non-Destructive Evaluation (NDE) relies on the scattering of waves from discontinuities, such as fractures or voids, to probe media otherwise invisible to the naked eye. Whilst this has been industrially exploited for several decades within acoustically transparent materials, many materials maintain a microstructure that causes scattering of the propagating waves. This undermines the aforementioned premise as it becomes exceedingly difficult to discern the features of interest from the scattering inherent to microstructural features, thereby limiting the range of materials which can be reliably inspected, non-destructively. Experimental investigations confirm the challenges and significant shortcomings for the inspection of future industrial components where such microstructures are desirable for their mechanical properties. It is demonstrated that the rapid increases in scattering with the insonifying frequency severely limit the achievable sensitivity of conventional ultrasound techniques. A review of the latest advances in ultrasound technology, including signal processing and imaging algorithms, explore the opportunities to exceed current limitations and advance the capability of ultrasonic NDE. Establishing these advances, and those of future approaches, requires a rigorous definition of performance. In contrast to commonly adopted strategies, a novel strategy which considers the probabilities of detection and false alarms is proposed as a valuable benchmark that can be used to make objective comparisons in terms of performance between competing algorithms. Future progress will also rely on a better scientific understanding of scattering, which can be provided by powerful modelling tools. Here, Finite Element modelling is established to be very useful; it captures the complex scattering physics and allows an investigative flexibility which can provide extremely useful insights. Whereas previous studies have often been restricted to weak scattering assumptions, the present FE modelling capability now enables the study of more complex, highly scattering environments. This is demonstrated by investigating ultrasonic arrays, where through optimising their engineering, especially in terms of their configuration, significant performance enhancements are shown to be possible. These important scientific tools have enabled the assessment of the latest imaging algorithms, the optimisation of inspection configurations, and increased our understanding of scattering phenomena. Their use in the future enables wide possibilities towards further pursuing the ultrasonic inspection of highly scattering materials.
Ionic-liquid-gating setup for stable measurements and reduced electronic inhomogeneity at low temperatures
Creators: name: Takahide, Yamaguchi
name: Sasama, Yosuke
name: Takeya, Hiroyuki
name: Takano, Yoshihiko
name: Kageura, Taisuke
name: Kawarada, Hiroshi
Publisher: name: arXiv
Year: 2018
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The ionic-liquid-gating technique can be applied to the search for novel physical phenomena at low temperatures because of its wide controllability of the charge carrier density. Ionic-liquid gated field-effect transistors are often fragile upon cooling, however, because of the large difference between the thermal expansion coefficients of frozen ionic liquids and solid target materials. In this paper, we provide a practical technique for setting up ionic-liquid-gated field-effect transistors for low-temperature measurements. It allows stable measurements and reduces the electronic inhomogeneity by reducing the shear strain generated in frozen ionic liquid.
description: 5 pages, 6 figures
TRT-5-François Berdougo
Creators: name: Leibowitch, Jacques (1942-2020)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: 1 fichier (2 pages). Autre destinataire : Renaud Persiaux
Static Casimir Condensate of Conformal Scalar Field in Friedmann Universe
Creators: name: Arbuzov, Andrej B.
name: Pavlov, Alexander E.
Publisher: name: arXiv
Year: 2018
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The quantum Casimir condensate of a conformal massive scalar field in a compact Friedmann universe is considered in the static approximation. The Abel-Plana formula is used for renormalization of divergent series in the condensate calculation. A differential relation between the static Casimir energy density and static Casimir condensate is derived.
description: 7 pages, 1 figure, misprints corrected
COSMIC LITHIUM: GOING UP OR COMING DOWN ?
Creators: name: STEIGMAN, GARY
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Observations of interstellar lithium provide a valuable complement to studies of lithium in Pop I and Pop II stars. Large corrections for unseen LiII and for non-gas phase lithium have provided obstacles to using interstellar data for abundance determinations. An approach to surmounting these difficulties is proposed and is applied to the Galaxy and the LMC. The key is that since potassium and lithium behave similarly regarding ionization and depletion, their observed ratio (LiI/KI) can be used to probe the abundance and evolution of lithium. For ten lines-of-sight in the interstellar medium of the Galaxy (ISM) the Li/K ratio observed $(\log (N_{Li}/N_K)_{ISM} = - 1.88 \pm 0.09)$ is entirely consistent with the solar system value $(\log (N_{Li}/N_{K})_{\odot} = - 1.82 \pm 0.05)$. The absence of LiI in front of SN87A in the LMC, coupled with the observed KI, corresponds to an upper bound (at $\rsim 95 \% \ CL$) of $\log (N_{Li}/N_K)_{LMC} < - 0.3 + \log (N_{Li}/N_K)_{ISM}.$ This low upper bound to LMC lithium suggests that cosmic lithium is on its way up from a primordial abundance lower, by at least a factor of two, than the present Pop I value of $[Li]_{PopI} \equiv 12 + \log (Li/H)_{PopI} = 3.2 \pm 0.1$.
description: Submitted to the ApJ (Part 1), April 14, 1995
The role of FGF19 in the diagnosis and pathophysiology of primary bile acid diarrhoea
Creators: name: Johnston, Ian
Publisher: name: Imperial College London
Year: 2015

description: Introduction: PBAD is a common cause of watery diarrhoea. It is diagnosed by the SeHCAT test and is characterized biochemically by elevated bile acid biosynthesis and low fasting FGF19. FGF19 is a gut hormone produced in the terminal ileum which negatively feeds back on hepatic BA synthesis. Aims: To assess the role of FGF19 in the pathogenesis of PBAD through characterization of fasting and postprandial FGF19 levels and through identification of associations with other biochemical and genetic factors. To show an increase in the fasting level of FGF19 in PBAD patients through the use of an FXR agonist. Methods: Subjects with PBAD and idiopathic diarrhoea were recruited and their data added to a previously recruited cohort. Fasting FGF19, BA, lipids, B12, vitamins A and D were measured. A subgroup was characterized using post-prandial levels of these factors. SNP genotyping was performed in candidate genes. A subgroup had BA species characterized by UPLC-MS. 10 PBAD subjects entered a study investigating changes in FGF19 following administration of the FXR agonist obeticholic acid. Results: Low fasting and post-prandial levels of FGF19 have been demonstrated in PBAD with lowest levels in those with low SeHCAT retention. Fasting and postprandial FGF19 correlates with total BAs. No strong associations have been found between diagnosis or FGF19 with vitamins A and D or with genetic variants. Approximately 30% of PBAD subjects have been found with elevated triglycerides and normal or high FGF19. Significant improvement in FGF19 and symptoms has been shown in PBAD subjects with the use of OCA. Conclusion: Abnormalities in FGF19 levels have been explored with biochemical phenotypes described. A subset of PBAD subjects with elevated triglycerides has been identified. A central role for total BAs in the aetiology has also been shown. Potential therapeutic benefit of OCA has been found warranting further investigation.
X-ray Constraints on the Intrinsic Shapes and Baryon Fractions of Five Abell Clusters
Creators: name: Buote, David A.
name: Canizares, Claude R.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We analyzed ROSAT PSPC images of the bright, nearby $(z<0.1)$ galaxy clusters A401, A1656 (Coma), A2029, A2199, and A2256 to constrain their intrinsic shapes and baryon fractions. Following Buote & Tsai we probed the aggregate structure of the clusters on scales $\sim 1.5h^{-1}_{80}$ Mpc to reduce effects of possible substructure on smaller scales ($\lesssim$ a few hundred kpc). The ellipticities of the X-ray isophotes are typically $ε\approx 0.15 - 0.25$ and display negative radial gradients significant (except Coma). By assuming hydrostatic equilibrium and a variety of mass models we obtain ellipticities $ε_{mass} \approx 0.40-0.55$ for isothermal models of the total gravitating matter of the clusters; the $ε_{mass}$ constraints change by $<10%$ upon consideration of the small temperature gradients shown by ASCA to be typical for rich clusters; the observed X-ray ellipticity gradients require that mass models with constant ellipticity have steep density profiles, $ρ\propto r^{-4}$. Estimates of the gas masses are highly insensitive to the ellipticities of the X-ray isophotes. The clusters in our sample have increasing fractions of gas mass to total mass with radius and have $M_{gas}/M_{tot} = (4% - 11%)h^{-3/2}_{80}$ within a radius $1.5h^{-1}_{80}$ Mpc, in excellent agreement with the results of White & Fabian and the Baryon Catastrophe proposed by White et al. (1993). Finally, the ellipticities of the dark matter distributions are essentially identical to $ε_{mass}$ and are consistent with the shapes of dark halos predicted by N-body simulations and the shapes of the galaxy isopleths in the clusters in contrast to our previous conclusions using {\it Einstein} data.
description: 29 pages (2 figures), PostScript, to appear in ApJ on February 1, 1996. No changes to the text -- the publication date given before was incorrect
title: ADCO, Cartulaire de Cîteaux pour les possessions de Dijon et du Dijonnais (XVe siècle), Cart. 175 (11 H 479), 115 folios, f. 0110
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2017
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Cartulaire de Cîteaux pour les possessions de Dijon et du Dijonnais (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 175 (11 H 479), 115 folios, f. 0110, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour les possessions de Dijon et du Dijonnais (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 175 (11 H 479), 115 folios, f. 0110, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
The Mini AGN at the Center of the Elliptical Galaxy NGC 4552 with HST
Creators: name: Cappellari, Michele
name: Renzini, Alvio
name: Greggio, Laura
name: Alighieri, Sperello di Serego
name: Buson, Lucio M.
name: Burstein, David
name: Bertola, Francesco
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The complex phenomenology shown by the UV-bright, variable spike first detected with the Hubble Space Telescope (HST) at the center of the otherwise normal galaxy NGC 4552 is further investigated with both HST imaging (FOC) and spectroscopy (FOS). HST/FOC images taken in 1991, 1993, and 1996 in the near UV have been analyzed in a homogeneous fashion, showing that the central spike has brightened by a factor ~4.5 between 1991 and 1993, and has decreased its luminosity by a factor ~2.0 between 1993 and 1996. FOS spectroscopy extending from the near UV to the red side of the optical spectrum reveals a strong UV continuum over the spectrum of the underlying galaxy, along with several emission lines in both the UV and the optical ranges. In spite of the low luminosity of the UV continuum of the spike (~3*10^5 Lsolar), the spike is definitely placed among AGNs by current diagnostics based on the emission line intensity ratios, being just on the borderline between Seyferts and LINERs. Line profiles are very broad, and both permitted and forbidden lines are best modelled with a combination of broad and narrow components, with FWHM of ~3000 km s^-1 and ~700 km s^-1, respectively. This evidence argues for the variable central spike being produced by a modest accretion event onto a central massive black hole (BH), with the accreted material having possibly being stripped from a a star in a close fly by with the BH. The 1996 broad Halpha luminosity of this mini-AGN is ~5.6*10^37 erg s^-1, about a factor of two less than that of the nucleus of NGC 4395, heretofore considered to be the faintest known AGN.
description: 40 pages, LaTeX, with 12 PostScript figures. Accepted for publication in the Astrophysical Journal
SBCARS 2021 - Investigating the use of Machine Learning algorithms to represent the Decision Maker profile in the Interactive Optimization of Product Line Design
Creators: name: Kuviatkovski, Fernando H.
name: Freire, Willian
name: M. M. Miotto Amaral, Aline
name: Colanzi, Thelma Elita
name: Delisandra Feltrim, Valéria
Publisher: name: figshare
Year: 2021
Subjects: subject: 80309 Software Engineering
subject: FOS: Computer and information sciences

description: Data from paper