cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Design and synthesis of metal organic frameworks for CO₂ separation and catalysis
Creators: name: Zhang, Jingming
Publisher: name: No Publisher Supplied
Year: 2013

description: Energy demand is currently a prevalent global issue that we are facing due to the   dramatic increase in both population and industrial processes around the world. Presently,   over 80% of the world's energy consumption is supplied by the burning of non-renewable   fossil fuels. The CO₂ gas emitted from this process has proven to contribute to global   warming. One possible strategy in addressing this problem is the development of   materials that can selectively capture CO₂ from flue gas mixtures. A new flexible   microporous metal-organic framework (MMOF), [Zn2(bpdc)2(bpe)]·2DMF (bpdc = 4,4'-  biphenyldicarboxylate,  bpe = 1,2-bis(4-pyridyl)-ethane, DMF = N,N-  dimethylformamide), was synthesized  and found to selectively capture CO2 over other   small gasses (N₂, CH₄, O₂ and CO), which makes it good candidate for CO₂ separation.       Another possible method to solve the energy crisis is to find an alternative, clean   and renewable energy source/carrier, such as hydrogen, to replace traditional fossil fuels.   Recently, scientists have proposed that producing hydrogen from the water splitting   process is an efficient and reliable way to create this clean burning fuel due to the high   abundance of water sources on earth. Water oxidation is considered to be the bottleneck   of the whole reaction due to the thermodynamic and kinetic limitations, hence   development of materials that can catalyze  water oxidation is then highly desired. A   previously reported Mn based MOF, [Mn₄(μ₃-OMe)(nic)₄] (nic = isonicotinate), was   synthesized and was found to form birnessite-type MnO₂ nanoparticles during the   photochemical water oxidation reaction, which is known to be an efficient heterogeneous   water oxidation catalyst.   In addition to water oxidation, MOFs can also be used as heterogeneous catalysts   for other organic transformations, with the active sites either integrated at metal nodes or   located on the backbones of the frameworks. A new  layered MOF structure,   [Co(Hoba)₂(H2O)₂] (H₂oba = 4,4'-oxydibenzoic acid), was synthesized and, after removal   of the terminal water molecules, was found to be a highly active heterogeneous catalyst   for olefin epoxidation with both high conversion and selectivity to form epoxide products.   Finally, synthesis, characterization, PL properties and preliminary results of gas   adsorption studies of a new MOF are described.
Rhoptromyrmex mayri Forel
Creators: name: Bolton, B.
Publisher: name: Zenodo
Year: 1979
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Rhoptromyrmex
Rhoptromyrmex mayri

description: Rhoptromyrmex mayri Forel
Rhoptromyrmex mayri Forel, 1912: 57. Syntype females, India: Poona (Wroughton) (BMNH) [examined]. Hagioxenus mayri (Forel); Brown, 1964 / 3: 19.
Brown (1964 b) indicated that this species was not a member of Rhoptromyrmex and proposed that it be transferred to genus Hagioxenus Forel, where it was left in the first part of this study (Bolton, 1976). Since then I have found four syntype females in the BMNH collection and dissection of two of them has shown that mayri is in fact correctly placed in Rhoptromyrmex, to which genus it is now formally returned.
The only Rhoptromyrmex species known from workers in India is R. wroughtonii Forel, and strangely the female of this species has not yet been discovered. It is tempting to assume that mayri represents the unknown female of wroughtonii but the differences between worker and queen seem greater than can be accounted for by the presumed parasitic lifeway of the females of this genus. In particular the pilosity in the queens representing mayri is much more dense and conspicuous than in wroughtonii workers, with spectacularly long hairs arising all over the legs and antennal scapes, which are absent from wroughtonii workers. On its own this character may not be significant but I think it best to leave the two separate until queen-associated samples of wroughtonii are forthcoming.
description: Published as part of Bolton, B., 1979, The ant tribe Tetramoriini (Hymenoptera: Formicidae). The genus Tetramorium Mayr in the Malagasy region and in the New World., pp. 129-181 in Bulletin of the British Museum (Natural History) Entomology 38 on page 173
Scorpiops vachoni
Creators: name: Tang, Victoria
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Scorpiones
Scorpiopidae
Scorpiops
Scorpiops vachoni

description: (29) Scorpiops vachoni (Zhu, Qi & Lourenço, 2005)
TYPE LOCALITY AND TYPE DEPOSITORY. China, Yunnan Province, Xishuangbanna Dai Autonomous Prefecture, Mengla County; MHBU (lost).
PROTONYM. Euscorpiops vachoni Qi, Zhu & Lourenço, 2005.
CHINESE EQUIVALENT. 瓦氏ẍx.
DISTRIBUTION (●). Yunnan: Xishuangbanna Prefecture (Mengla County: Bujiao and Manlongdai villages).
REMARKS. New locality with precise coordinates (from Manlongdai) was referenced from one iNaturalist observation identified by the current author: 200190520.
description: Published as part of Tang, Victoria, 2025, A review of scorpiofauna of China: nomenclatural notes and updated faunistic catalogue (Arachnida: Scorpiones), pp. 1-24 in Euscorpius 404 on page 19, DOI: 10.5281/zenodo.14660932
Additional file 2: Table S1. of Follow-up in patients with a burn-related emergency department visit: a feasibility study
Creators: name: H. Goei
name: B. Wijnen
name: S. Mans
name: M. De Jongh
name: C. Van Der Vlies
name: S. Polinder
name: N. Van Loey
name: M. Van Baar
Publisher: name: Figshare
Year: 2017
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Science Policy

description: Detailed response analysis by recruitment strategy (DOCX 16Â kb)
Transferable strategic meta-reasoning models
Creators: name: Wunder, Michael
Publisher: name: No Publisher Supplied
Year: 2013

description: How do strategic agents make decisions? For the first time, a confluence  of advances in agent design, formation of massive online data sets of social  behavior, and computational techniques have allowed for researchers to construct  and learn much richer models than before. My central thesis is that,  when agents engaged in repeated strategic interaction undertake a reasoning  or learning process, the behavior resulting from this process can be characterized  by two factors: depth of reasoning over base rules and time-horizon  of planning. Values for these factors can be learned effectively from interaction  and are transferable to new games, producing highly effective strategic  responses. The dissertation formally presents a framework for addressing the  problem of predicting a population’s behavior using a meta-reasoning model  containing these strategic components. To evaluate this model, I explore several  experimental case studies that show how to use the framework to predict  and respond to behavior using observed data, covering settings ranging from  a small number of computer agents to a larger number of human participants.
Ligand-mediated tumor supression by a neuropeptide
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Esophageal cancer related gene 4 (ECRG4) is a novel gene encoding a neuropeptide, Augurin, which we have identified as a functional ligand. Its expression is uniformly lost in various types of cancer and in proliferating cells, indicating its role as a potential tumor suppressor. However, the mechanism of its suppression of tumor growth in certain cancers and its role in malignant glioma are unknown. We hypothesize that Augurin is a tumor suppressor(s) of malignant glioma, and that the restoration of their expression into glioma cells will inhibit tumor growth and invasion. To test this hypothesis, we propose to introduce the Augurin cDNA into glioma cells and characterize their proliferation and migration properties. Orthotopic tumor xenografts expressing Augurin will be examined in parallel to assess the effect of Augurin on invasion of malignant glioma. The focus of Aim I will be on the measurement of the proliferation and invasion of tumor cells expressing the Augurin gene in comparison with parental cells. Growth of tumors expressing Augurin in an inducible manner will be measured using firefly luciferase as a reporter in combination with immunohistochemical techniques to localize and quantitate secondary, infiltrating tumor burden. Aim II focuses on the higher risk but the more translational potential of using recombinant Augurin to target glioma growth. Since Augurin is a functional ligand, We will evaluate the potential of recombinant Augurin peptide as a novel biotherapeutic for glioma by directly adding Augurin protein to glioma cells and monitoring the effect on proliferation and migration. These series of studies are designed to test the hypothesis that if Augurin’s natural expression is restored in tumors or if the ligand is delivered to the tumor, it will inhibit tumor growth, thus creating a novel therapeutic for glioma. These studies are non-overlapping with our ongoing glioma studies. Funding of this proposal through the CCRC mechanism is essential since it is preliminary and requires additional data so that we can be successful in the funding of further studies through the NIH.
Displacement of DNA-molecular-mimic σR1.1 from the RNA polymerase active-center cleft
Creators: name: Xu, Qumiao
Publisher: name: No Publisher Supplied
Year: 2013

description: The N-terminal conserved region of σ (σR1.1) is a highly negatively charged segment with 90-100 amino acids. In free σ, it interacts with DNA-binding determinants on σ, preventing free σ from association with promoter DNA. In RNA polymerase (RNAP) holoenzyme, σR1.1 no longer masks DNA-binding determinants on σ, therefore enabling association with promoter DNA. Deletion of σR1.1 has significant effects on rates of formation of RNAP-promoter open complex (RPo).     The solution structure of σR1.1 has been solved by NMR. Ensemble fluorescence resonance energy transfer (FRET) analysis indicate that σR1.1 acts as a “molecular-mimic” of DNA by occupying the active-center cleft in RNAP holoenzyme, and must be displaced out of the active-center cleft upon formation of RPo. However, the precise positions and orientations of σR1.1 in holoenzyme and RPo have remained uncertain.     Recent crystal structures of σR1.1 in RNAP holoenzyme from two groups—Murakami and co-workers and Darst and co-workers—place σR1.1 in RNAP holoenzyme inside the RNAP active-center cleft, consistent with the ensemble FRET analysis, but the folds and the rotational orientations of σR1.1 in the crystal structures from the two groups are different.     In this work, I have used systematic single-molecule FRET and distance-restrained docking to define the positions and rotational orientations of σR1.1 in RNAP holoenzyme in solution and in RPo in solution. The results for RNAP holoenzyme indicate that, in RNAP holoenzyme in solution, σR1.1 is located inside the active-center cleft, in a position and rotational orientation consistent with the crystal structure from Darst and co-workers. The results for RPo indicate that, in RPo in solution, σR1.1 is located outside the active-center cleft—at least 40 Å away from its position in holoenzyme—is positioned between the RNAP β’ jaw and β dispensable region 1 (βDR1), and potentially  makes direct protein-protein interactions with βDR1.     Deletion of βDR1 affects the rate and temperature-dependence of formation of RPo and alters the footprint of RPo. My results suggest that, upon formation of RPo, σR1.1 is displaced from the RNAP active-center cleft to a binding site on βDR1, and, as such, provide an explanation for previously detected effects of deleting βDR1.
Influence of SRC signaling on human pancreatic cancer progression
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Pancreatic cancer is the 4th leading cause of cancer-related deaths in the United States with an overall median survival of less than one year. Both cytotoxic and molecular based therapies have been largely ineffective at improving survival. This application is designed to address the poor progress that has been made with the therapies for pancreatic cancer. SRC is a nonreceptor tyrosine kinase that is involved in the progression of a number of malignancies, including pancreatic cancer. Our preliminary results have confirmed the previous findings that SRC activity is increased in pancreatic cancer and also associated with reduced overall survival. We hypothesize that those changes associated with poor survival (e.g. SRC) are also responsible for the rapid progression of pancreatic cancer. We have recently opened a UCLA-based phase II Dasatinib clinical trial for patients with resected pancreatic cancer. For this CRCC project, we will first investigate the biochemical and phenotypic consequences of lentiviral induced SRC dysregulation (overexpression and inhibition) on human pancreatic cancer progression in vitro using immortalized pancreatic cancer cell lines that have been profiled for SRC signaling activity (i.e. SRC high and low). In parallel, our validated human tumor xenograft model will be used test the hypothesis that SRC inhibition in the subgroup of patients with evidence of enhanced SRC activation will improve survival (i.e. activated SRC as an accurate predictive biomarker for SRC inhibition). Mice will be treated with the SRC inhibitor Dasatinib and the phenotypic and biochemical consequences of SRC inhibition on tumor growth and downstream targets will be examined in vivo and compared between the responders and nonresponders. Furthermore, we will also leverage our preclinical findings on the tumor samples from the responders and nonresponders enrolled in the Phase II Dasatinib clinical trial. In all, we aim to identify accurate predictive biomarkers for SRC inhibition as well as effective therapies that can be combined with Dasatinib to improve the overall prognosis of patients with pancreatic cancer.
Using the novel cytokine IL-17D to stimulate immune responses to cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Immune suppressed humans and mice have a higher incidence of cancer, suggesting that the immune system performs tumor surveillance. The immune cells and molecules that participate in the tumor surveillance response are not well described, since this response often occurs without clinical signs or symptoms. In order to study tumor surveillance, we have generated highly immunogenic tumor cell lines, called "regressors", in immune-deficient mice. Regressor cell lines are rejected by the immune system when transplanted into naive, syngeneic mice, thereby providing a model for the study of tumor surveillance. Using microarray data, we have found that the novel cytokine IL-17D is differentially expressed in regressor cell lines compared to "progressor" cell lines that are not rejected by the immune system. Our preliminary data show that overexpression of IL-17D is sufficient to induce tumor rejection, which requires neutrophils. Based on this, we propose to study the mechanism of action of tumor rejection by testing the hypothesis that tumor-expressed IL-17D recruits neutrophils, leading to tumor killing. We propose to achieve the following objectives. AIM 1-Examine the effect of overexpression and silencing of IL-17D on neutrophil number and quantity in tumors. METHODS-Generate tumor cell lines with overexpressed or silenced IL-17D, transplant the cell lines into syngeneic mice, and examine the quantity and activation state of immune cells such as neutrophils using flow cytometry and immunohistochemistry. Use recently described markers of neutrophil lineage including ICAM1 and TNF to determine the potential function of neutrophils inside tumors. AIM 2. Examine the ability of neutrophils isolated from IL-17D-hi and -lo tumors to kill tumor cells. METHODS-Isolate neutrophils from tumors using magnetic beads or flow sorting and examine their ability to kill tumor cells and produce nitric oxide, reactive oxygen intermediates, and cathelicidin in vitro in response to tumor cells or control stimulations with formyl peptides or hydrogen peroxide. Compare tumor-associated neutrophils with normal neutrophils isolated from bone marrow.
Eleotris amblyopsis
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Perciformes
Eleotridae
Eleotris
Eleotris amblyopsis

description: Eleotris amblyopsis (Cope 1871). Large-Scaled Spinycheek Sleeper; Guavina, Pez Perro, Lucia, Dormilón, Dormilón Oscuro
Vouchers: UCR 0267-009 (1), 0448-005 (2) and 0449-002 (1); FMNH IBUNAM 13775 (1) and 13777 (1).
Distribution: Western Atlantic Ocean; from North Carolina, USA, to southeastern Brazil; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) UI, WK, Pr, GM, KP, Es, BF, IM and To (Atlantic); 0–18 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; LC (2019), population trend stable.
Literature: Villa (1982: 222; detailed description, including illustrations and an identification key, and information on distribution and ecology), Bussing (1998: 413; brief description, including illustrations and an identification key, and information on distribution, with a map, and ecology), van den Berghe (2015: 39, as Eliotris amblyopsis — misspelled; listed, including an illustration and information on distribution and ecology), Robertson & Van Tassell (2019: 4095; detailed description, including illustrations, and information on distribution, with a map, and ecology) and Angulo (2021: 34; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 32, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Crepidomanes inopinatum (Pic.Serm.) J.P.Roux
Creators: name: Ahamada H. Saïd
name: Sabine Hennequin
name: Germinal Rouhan
name: Jean-Yves Dubuisson
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Crepidomanes
Crepidomanes inopinatum

description: Crepidomanes inopinatum (Pic.Serm.) J.P.Roux
MADAGASCAR: Eminiminy, Versant Est et sommet du Trafon’omby, 30 Oct. 1995, F.Rakotondrainibe 3005 (P00067100); Réserve Spéciale d’Ivohibe, à 8 km à l’est du village d’Ivohibe, 19 Oct. 1997, F.Rakotondrainibe 4173 (P00134194); Réserve Spéciale d’Ambohitantely, 9 Dec. 1997, F.Rakotondrainibe 4456 (P00134529); PN de Ranomafana, Forêt de Vatoharanana, 8 Oct. 2000, F.Rakotondrainibe 5931 (P00212410).
LA RÉUNION: 1832, J.N.Bréon s.n. (P01522393); May 1847, A.C.J.Bernier 907 (P01522402); 1892, H.J. de Cordemoy 133bis (P00477827); 1895, H.J. de Cordemoy s.n. (P01522401).
description: Published as part of Ahamada H. Saïd, Sabine Hennequin, Germinal Rouhan & Jean-Yves Dubuisson, 2017, Disentangling the diversity and taxonomy of Hymenophyllaceae (Hymenophyllales, Polypodiidae) in the Comoros, pp. 1-53 in European Journal of Taxonomy 313 on page 51, DOI: 10.5852/ejt.2017.313, http://zenodo.org/record/896401
Scorpiops vonwicki Birula 1913
Creators: name: Tang, Victoria
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Scorpiones
Scorpiopidae
Scorpiops
Scorpiops vonwicki

description: (31) Scorpiops vonwicki Birula, 1913
TYPE LOCALITY AND TYPE DEPOSITORY. India, Arunachal Pradesh State (or China, “ Zangnan ”; disputed territory), Abor Hills; ZISP.
PROTONYM. Scorpiops petersi von-wicki Birula, 1913.
CHINESE EQUIVALENT. +氏ẍx.
DISTRIBUTION (●). Xizang: Nyingchi City (Mêdog County); = “ Arunachal Pradesh: Abor Hills”.
description: Published as part of Tang, Victoria, 2025, A review of scorpiofauna of China: nomenclatural notes and updated faunistic catalogue (Arachnida: Scorpiones), pp. 1-24 in Euscorpius 404 on page 19, DOI: 10.5281/zenodo.14660932
Tetramorium melanogyna Mann
Creators: name: Bolton, B.
Publisher: name: Zenodo
Year: 1979
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium melanogyna
Tetramorium insolens

description: Tetramorium melanogyna Mann sp. rev.
Tetramorium melanogyna Mann, 1919: 345, fig. 28. Syntype workers, female, Solomon Is.: Ugi, Pawa, 1916 (W. M. Mann) and Three Sisters, Malapaina, 1916 (W. M. Mann) (MCZ, Cambridge; USNM, Washington) [examined]. Tetramorium melanogyna Mann; Bolton, 1977: 99 [as synonym of T. insolens (F. Smith)].
A critical reappraisal of the material of melanogyna presently available for study has convinced me that I was mistaken in synonymizing this species with the much more widespread T. insolens, and I hereby reverse that decision, restoring melanogyna to its original status as a good species.
As far as is known melanogyna is restricted to the Solomon Islands and thus it is only specimens from here which may be confused with insolens, which also occurs on these islands. Samples of melanogyna workers will key out at insolens in Bolton (1977), but the two may be distinguished as follows.
insolens
Gaster lighter in shade than head and alitrunk.
Hairs on dorsal (outer) surface of hind tibiae suberect to subdecumbent.
Rugoreticulum on postpetiole dorsum very strong, as well developed as on pronotum.
In a majority of workers the rugose sculpturing of the alitrunk forming a transverse ridge at promesonotal junction.
melanogyna
Gaster darker in shade than head and alitrunk, or at least with an infuscated transverse band.
Hairs on dorsal (outer) surface of hind tibiae decumbent to appressed.
Rugoreticulum on postpetiole dorsum weak, more feebly developed than on pronotum.
Rugose sculpturing of alitrunk not forming a transverse ridge at promesonotal junction.
The queens of the two species are easily distinguished as in insolens the female has the same colouring as the workers, whilst in melanogyna the queen is uniform dark brown. Other names given as synonyms of insolens in Bolton (1977: 99) remain as such.
Correction to key. In the key to Tetramorium of the Oriental and Indo-Australian regions (Bolton, 1977: 72), the second half of couplet 13 should read, ' Dorsum of postpetiole unsculptured. .. ', not ' Dorsum of petiole' as is printed. This brings it in line with the first half of the couplet.
description: Published as part of Bolton, B., 1979, The ant tribe Tetramoriini (Hymenoptera: Formicidae). The genus Tetramorium Mayr in the Malagasy region and in the New World., pp. 129-181 in Bulletin of the British Museum (Natural History) Entomology 38 on pages 173-174
Dysregulated pHi and adaptive behaviors of cancer cells
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Dysregulated pH is emerging as a hallmark of cancers, regardless of their tissue origin or genetic background. In normal cells, extracellular pH (pHe) is higher than intracellular pH (pHi). However, in cancer cells there is a reversal of this pH gradient with pHi being greater than pHe, which creates a perfect storm for cancer progression. Lower pHe stimulates acid-activated proteases and extracellular matrix disassembly, and higher pHi promotes cell proliferation, cell survival, and directed cell migration for metastasis. A current view is that increased pHi may be a common critical driving force for cell transformation and tumor progression. However, this prediction has not been adequately verified in situ. Our overall hypothesis is that increased pHi facilitates the adaptive behaviors of cancer cells that allow them proliferate and survive. To begin testing this hypothesis, the objective of this proposal is to identify pH sensitive pathways and genes that regulate adaptive cell behaviors. Our objective will be accomplished by using Drosophila models we recently generated that overexpress or lack a ubiquitous Na-H exchanger encoded by Dnhe2. As key regulators of cellular H+ efflux, NHEs are upregulated in human cancers, which contributes to dysregulated pHi. Our aim is to use genetic screens to identify genes and signaling pathways that are sensitive to disregulated pH for acquiring adaptive behaviors of cancer cells. Our preliminary data suggest synthetic lethality with loss of Dnhe2 and expression of oncogenic Raf, and dyplasia with overexpression of Dnhe2 in the absence of activated oncogenes. We now will ask whether the phenotypes of mutation or overexpression of candidate genes and signaling pathways regulating cancer progression in human cells are altered by changes in pHi by increasing or decreasing expression of Dnhe2. This screening approach. which cannot readily be achieved using mouse models, will identify pH-sensitive oncogenic and tumor suppressor pathways that would be used to support an extramural funding application that would 1) determine mechanistically how dysregulated pH contributes to cancer progression, and 2) identify strategies to target pH-regulated mechanisms as a therapeutic approach to limiting disease progression.
Scorpiops wrzecionkoi Kovarik 2020
Creators: name: Tang, Victoria
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Scorpiones
Scorpiopidae
Scorpiops
Scorpiops wrzecionkoi

description: (32) Scorpiops wrzecionkoi Kovařík, 2020
TYPE LOCALITY AND TYPE DEPOSITORY. China, Tibet Autonomous Region, Shannan City, Nagarzê County, near Sangjian; FKCP.
CHINESE EQUIVALENT. 帷氏ẍx [corrected transliteration].
DISTRIBUTION (●). Xizang: Shannan City (Nagarzê County: near Sangjian).
description: Published as part of Tang, Victoria, 2025, A review of scorpiofauna of China: nomenclatural notes and updated faunistic catalogue (Arachnida: Scorpiones), pp. 1-24 in Euscorpius 404 on page 19, DOI: 10.5281/zenodo.14660932
Eleotris perniger
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Perciformes
Eleotridae
Eleotris
Eleotris perniger

description: Eleotris perniger (Cope 1871). Smallscaled Spinycheek Sleeper; Guavina Espinosa
Vouchers: UCR 3224-001 (1); FMNH 5925 (15), 5926 (30), 5927 (6), 5928 (1), 14629 (1), 14630 (1), 14631 (1), 14632 (1), 14633 (1), 14634 (1), 14635 (1), 14636 (1), 14637 (1), 14638 (1), 14639 (1), 14640 (1), 52272 (7) and 126133 (6); LSUMZ 15328 (1). Distribution: Western Atlantic Ocean; from Florida, USA, to northern Brazil; entering estuaries and littoral lagoons and ascending river courses; (Nicaragua) UI, WK, Pr, GM, KP, Es, BF, IM and To (Atlantic); 0–15 masl; Per, Dia, Amp. Occurrence and conservation status: Nat; LC (2019), population trend unknown. Literature: Villa (1982: 222, as Eleotris pisonis (Gmelin 1789) —misidentification; detailed description, including illustrations and an identification key, and information on distribution and ecology), Bussing (1998: 417, as E. pisonis —missidentification; brief description, including illustrations and an identification key, and information on distribution, with a map, and ecology), van den Berghe (2015: 38, as Eliotris pictus —misspelled and misidentification; listed, including an illustration and information on distribution and ecology), Robertson & Van Tassell (2019: 4097; detailed description, including illustrations, and information on distribution, with a map, and ecology) and Angulo (2021: 34; listed, including information on distribution) and Angulo (2021: 34; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 32, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Analysis of HGF-induced cell invasion in a three-dimensional matrix
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cancer cell invasion is facilitated by destruction of cell-cell adhesion by down-regulation of epithelial (E) cadherin, a protein that is required for the maintenance of stable junctions. Cancer cell invasion, however, is not a single cell event. Rather, metastatic cells often coordinate their migration while maintaining the contacts between cells. Interestingly, the newly acquired mesenchymal phenotype is often accompanied by an up-regulation of the mesenchymal cadherin, neural (N) cadherin. Thus, it seems that these cells should be capable of maintaining at least some levels of cell-cell adhesion. How the extent of adhesion between invasive cells affects cancer cell invasion remains unknown and will be addressed in this proposal. When treated with Hepatocyte Growth Factor (HGF), normal epithelial MDCK cells become highly invasive and undergo a complete E-to-N cadherin switch as a part of Epithelial-to-Mesenchymal Transition (EMT). HGF-induced cell invasion will be analyzed in a 3D collagen matrix using our live-cell confocal imaging system, and the roles of cell-cell interactions will be probed using novel traction force analysis. Since the actin cytoskeleton plays a critical role in maintaining cell-cell junctions, we will analyze the dynamics and organization of the actin cytoskeleton at the cell-cell contacts between invasive cells. We hypothesize that N-cadherin-mediated junctions regulate the strength and stability of cellcell adhesion between invasive cells and ultimately their invasive behavior. We will (1) develop a 3D cell invasion model and analyze the roles of cadherins; (2) analyze traction forces exerted by invading cells and the effect of this force on N-cadherin junctions; (3) examine the roles of the actin cytoskeleton at force bearing cell contacts between invasive cells. Through quantitative analysis of cell-cell interactions between invasive cells, our proposal will contribute to our understanding of how cancer cells invade and metastasize. Our long-term goal is to identify N-cadherin-specific inhibitors that compromise N-cadherin-mediated cell-cell adhesion, thereby preventing collective cell invasion. This inhibitor will ultimately test whether cell-cell adhesion is required for metastasis in vivo, and could ultimately serve as a therapeutic agent.
Facial expression transfer by using 3D-aware expression flow
Creators: name: Yang, Fei
Publisher: name: No Publisher Supplied
Year: 2013

description: We study the problem of transferring facial expressions from one face to another. Direct copying and blending face components using existing methods results in semantically unnatural composites, since expression is a global effect and a local face component in one expression is often incompatible with the shape and other components in another expression. To solve this problem we present the expression flow method, which is a 2D flow field that can warp the target face globally.  We develop a shape fitting algorithm, which jointly constructs 3D face shapes to the input images with the same identity but different expressions. The expression flow is computed by projecting the difference between the two 3D shapes to 2D image plane. We apply our algorithms in several applications including face compositing, face morphing, video stitching, and facial expression exaggeration. Our system is able to generate faces with much higher fidelity than existing methods.
Stabilin-1 expressing macrophages and control of glioma
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: One of the prime objectives of cancer research is the minimization of tumor growth and metastasis. Glioma’s are especially hard to treat, can be highly aggressive and the average prognosis remains under two years even with combined therapies. The sensitive environment i.e. the brain, and the highly invasive nature of these tumors prevents complete surgical removal. The molecule SPARC is associated with tumor invasiveness and metastasis and resistance to cell death pathways. The inhibition of SPARC using siRNA methods has recently been demonstrated to reduce tumor cell migration and invasion and increase host survival. In this proposal we address the ability of the only known receptor for SPARC, stabilin-1 to inhibit glioma invasion via the inhibition of SPARC and a reduction in extracellular matrix deposition. Stabilin-1 is a scavenger receptor that is expressed by alternatively activated macrophages (AAMac). Unlike classical inflammatory macrophages, AAMacs are associated with tissue remodeling and are involved in extracellular matrix removal and deposition. To test the hypothesis, Stabilin-1 expressing macrophages can inhibit glioma growth, we will a) investigate the expression of stabilin-1 by tumor associated macrophages (TAM) in the GL261 tumor cell line model of glioma over time and b) transfer in vitro differentiated stabilin-1 expressing macrophages into glioma+ mice and monitor: the expression of SPARC; the growth of the tumor; and the migration and infiltration of stabilin-1 expressing macrophages in the tumor and normal brain. Stabilin-1 and SPARC will be measured by real-time PCR and localized by immunohistochemistry. The size and phenotype of the macrophage population in the brain will be quantified by flow cytometry. The behaviour of transferred macrophages will be imaged and analyzed using multi-photon microscopy to determine their ability to invade, migrate and interact with tumor cells. The results of these experiments will determine the phenotype of tumor-associated macrophages and their expression of stabilin-1 and AAMac phenotypes in a glioma model. In addition, these experiments will establish the ability of tissue remodeling macrophages to migrate to the brain, enter the tumor and prevent glioma growth.
Scorpiops yangi
Creators: name: Tang, Victoria
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Scorpiones
Scorpiopidae
Scorpiops
Scorpiops yangi

description: (34) Scorpiops yangi (Zhu, Zhang & Lourenço, 2007)
TYPE LOCALITY AND TYPE DEPOSITORY. China, Yunnan Province, Wenshan Zhuang and MiaoAutonomous Prefecture, Maguan County, Gulinqing Township; MHBU (lost).
PROTONYM. Euscorpiops yangi Zhu, Zhang & Lourenço, 2007.
CHINESE EQUIVALENT. 杨氏ẍx.
DISTRIBUTION (●). Yunnan: Wenshan Prefecture (Maguan (Gulinqing Township) and Malipo counties).
description: Published as part of Tang, Victoria, 2025, A review of scorpiofauna of China: nomenclatural notes and updated faunistic catalogue (Arachnida: Scorpiones), pp. 1-24 in Euscorpius 404 on page 19, DOI: 10.5281/zenodo.14660932
Leukemia-specific ligands against childhood acute lymphoblastic leukemia
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Current treatment for childhood acute lymphoblastic leukemia (ALL) has dose limitations due to its toxicities to normal tissues. A novel approach, i.e., using a cell surface binding ligand, is desired to deliver treatment preferentially to leukemia cells. LLP2A, discovered by my mentor, Dr. Kit Lam, is a high-affinity and high-specificity peptidomimetic ligand against an activated, but not resting, a4ß1 integrin found on adult malignant lymphoid cells. Our preliminary data showed that childhood ALL cells expressed activated a4ß1 integrin and bound to LLP2A. Furthermore, the screening results of LLP2A-related onebead one-compound (OBOC) combinatorial libraries indicated that there may be ligands which are more specific to childhood ALL cells than LLP2A. The goal of this proposal is to identify unique ligands that are similar to LLP2A but more specific and with a higher affinity to childhood ALL. Two highly focused LLP2A-related OBOC combinatorial libraries will be screened using primary ALL cells from pediatric patients at diagnosis. Selected beads will be further screened for leukemia specificity using normal hematopoietic cells (bone marrow or blood cells including CD34 cells). Once the leukemia-specific ligands are identified, binding affinity of the ligands will be tested by flow cytometry using a series of ALL samples which were frozen at diagnosis or transplanted in NOD/SCID/IL2R ? (NSG) mice. NSG mice will be used to maintain primary leukemia cells, since primary leukemia cells do not grow well in vitro. LLP2A will be used as a control and median fluorescence intensity will be used to determine binding affinity of ligands relative to LLP2A binding affinity. Normal hematopoietic cells described above will be tested the same way to confirm no or minimal binding. If successful, the ligands with high specificity and affinity to childhood ALL found in this project will be used as vehicles to deliver chemotherapeutic agents to leukemia cells as a targeted therapy.
Developing an epistasis map for DNA replication and repair genes in human breast cancer cells
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Our goal is to generate epistasis maps for genes involved in DNA replication and DNA repair in human normal mammary epithelial and breast cancer cells. We will employ Epistasis Miniarray Profiling (E-MAP), a powerful approach that can be used to delineate functional pathways through high-density, quantitative assessment of the effects of pair-wise gene disruptions. The effects of individual and pair wise knockdown of ~200 proteins that function in DNA replication and the DNA damage response on cell proliferation and cell cycle profiles will be assayed in a quantitative fashion. Computational approaches established for analysis of epistatic relationships in yeast will be used to analyze this data set at the level of a) the individual interacting gene pair, b) sets of gene pairs operating in pathways or complexes, and c) the entire data set, with particular attention to epistatic effects specific to cancer cells. Yeast E-MAP analysis has revealed the power of this approach in identifying previously unrecognized connections between pathways, and determining which pathways are redundant. Thus, human DNA repair and DNA replication E-MAP analyses are likely to increase our understanding of the biology of these processes in normal and cancer cells. The normal and cancer epistasis maps will provide a significant resource, which can be used by the basic biomedical research community to drive hypothesis driven research and by the translational research community to develop new diagnostic and therapeutic strategies.
Role of the normal stomach microbial flora in Helicobacter pylori-induced inflammation
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The bacterium Helicobacter pylori dwells in the stomachs of about half the world’s population, causing a chronic infection that results in an immune cell infiltration called inflammation. This inflammation in turn can remain asymptomatic or develop into ulcer disease or gastric cancer in a subset of patients. It is not known why some infected people develop disease while others do not. Our preliminary results suggest that H. pylori ousts a member of the normal microbial flora as part of its pathway to inducing inflammation. We propose experiments here to characterize the timing and consequence of removal of this normal flora microbe, as well as to characterize whether other members of the stomach microflora are affected by H. pylori infection. A finding that a member of the normal stomach microflora is able to inhibit H. pylori disease would have significant impact, in that we could then actively utilize this microbe as a preventative measure. Objective. To determine the kinetics and consequences of H. pylori-triggered removal of murine Lactobacilli and to examine the microbial population response of the murine stomach microflora to H. pylori infection. Methods to be used. We will use infection models coupled with quantitative polymerase chain reaction to analyze how our target Lactobacillus species is affected by H. pylori colonization, and also to determine the consequences of removal of this species in terms of H. pylori disease. Furthermore, we will use analysis of the 16S ribosomal RNA gene diversity to determine whether H. pylori colonization causes changes in the normal microbes of the stomach.
Method matters
Creators: name: Yeh, Vivian M.
Publisher: name: No Publisher Supplied
Year: 2013

description: Attention bias, or increased attention to smoking relative to neutral cues, may be a useful marker for relapse risk; however, attention bias has not been consistently documented in continuing smokers which limits its utility for treatment planning. This study assessed attention bias in continuing smokers experiencing a mild stressor. Attention narrowing, or increased attention to smoking relative to other positive cues, was also studied to assess the specificity of distress effects on attention to smoking cues. Analyses also explored the degree to which attention bias and narrowing predicted smoking lapses. In addition, because the mild stressor used was somewhat novel, we tested the degree to which unpredictable noise induced attention bias toward negative cues and subjective distress relative to control. Data were collected in two similar study designs in smokers preparing for a quit attempt. Designs differed in the control conditions against which stress was compared within subjects (Design 1 = predictable noise, Design 2 = silence). Attention was assessed using a modified Stroop task with neutral, negative, positive, and smoking words. Design, Stress Order (whether unpredictable noise was presented first or last), and Word Order (whether smoking words were presented first or last) were included in analyses to explore their potential effects on attention. Results indicated that attention bias effects were greater in Design 1 than Design 2 and when stress was presented first rather than last, although attention bias toward smoking cues was small in magnitude in all conditions. No evidence for attention narrowing was found. Attention bias and narrowing under mild stress were not related to later smoking lapses. Although the stress manipulation did not increase distress relative to control, it corresponded with a negative bias as anticipated. The magnitude of this effect varied across study designs. Overall findings suggest attention bias effects are not robust among continuing smokers experiencing unpredictable noise stress, and effect sizes vary as a function of design elements in important ways. Further research is necessary to determine the optimal context to reliably assess attention bias in continuing smokers.
Crepidomanes minutum var. mascarenensis Pynee & Dubuisson
Creators: name: Ahamada H. Saïd
name: Sabine Hennequin
name: Germinal Rouhan
name: Jean-Yves Dubuisson
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Crepidomanes
Crepidomanes minutum
Crepidomanes minutum (blume) k.iwats. var. mascarenensis pynee & dubuisson

description: Crepidomanes minutum (Blume) K.Iwats. var. mascarenensis Pynee & Dubuisson
Mascarenian specimens listed in Pynee et al. (2012).
description: Published as part of Ahamada H. Saïd, Sabine Hennequin, Germinal Rouhan & Jean-Yves Dubuisson, 2017, Disentangling the diversity and taxonomy of Hymenophyllaceae (Hymenophyllales, Polypodiidae) in the Comoros, pp. 1-53 in European Journal of Taxonomy 313 on page 51, DOI: 10.5852/ejt.2017.313, http://zenodo.org/record/896401
Additional file 4: Figure S2. of XTHs from Fragaria vesca: genomic structure and transcriptomic analysis in ripening fruit and other tissues
Creators: name: Opazo, María
name: Lizana, Rodrigo
name: Yazmina Stappung
name: Davis, Thomas
name: Herrera, Raúl
name: Moya-León, María
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: The multiple alignment of deduced amino acid sequences of FvXTHs belonging to group IIIA and IIIB. The catalytic conserved domain (DEIDFEFLG), the secondary structures of β sheets (arrows) and α-helices (spiral), and loops 1, 2 and 3 (lines) are indicated (PDF 494 kb)
title: PERSPEKTIF MASYARAKAT TERHADAP PENGARUH PENDIDIKAN BAGI PEREMPUAN DI INDONESIA
title: PENDIDIKAN BAGI PEREMPUAN
titleType: Other
Creators: name: Lifde Clara Tambunan, Lifde Clara
name: Lifde Clara Tambunan
Publisher: name: Zenodo
Year: 2024

description: Zaman semakin maju,ilmu semakin berkembang,perkembangan teknologi semakin maju, semua hal-hal ini dikembangkan oleh ilmu dan pengetahuan. Pendidikan dapat didapatkan oleh setiap orang, terutama bagi seorang perempuan, dengan pendidikan perempuan dapat mencapai karier
Crepidomanes trinerve (Baker) Dubuisson & Ebihara
Creators: name: Ahamada H. Saïd
name: Sabine Hennequin
name: Germinal Rouhan
name: Jean-Yves Dubuisson
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Crepidomanes
Crepidomanes trinerve

description: Crepidomanes trinerve (Baker) Dubuisson & Ebihara
MADAGASCAR: Parc national Montagne d’Ambre, 24 Jun. 1992, F.Rakotondrainibe 1725 (P00100238); Réserve spéciale d’Ambohitantely, 11 Dec. 1997, F.Rakotondrainibe 4495 (P00134573).
See also Mauritian specimens listed in Dubuisson et al. (2013b).
description: Published as part of Ahamada H. Saïd, Sabine Hennequin, Germinal Rouhan & Jean-Yves Dubuisson, 2017, Disentangling the diversity and taxonomy of Hymenophyllaceae (Hymenophyllales, Polypodiidae) in the Comoros, pp. 1-53 in European Journal of Taxonomy 313 on page 51, DOI: 10.5852/ejt.2017.313, http://zenodo.org/record/896401