cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Vom Muttenwändli ob Muttensee am Kistenpass : NB bey heftigem Föhnwind
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1877

description: IM
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Analysis of soft encapsulation methods for acutely implantable high-channel count neural recording electronics
Creators: name: Taylor, Trevor Winn
Publisher: name: University of Utah
Year: 2014
Subjects: Electronics
Encapsulation
Implant
Neural
Potting
Silicone

description: Advances in neural interfaces are putting digitization electronics closer to the patient. Since a fully implantable system is desired, there is need for a viable method for encapsulating electronics intended for implantation using a soft encapsulation method. For this thesis, several encapsulation methods were tested. Testing was split into three phases: a viability phase, a preliminary phase, and a verification phase. In the viability and preliminary phases, a method using layered Parylene C and polydimethylsiloxane was identified as having the best barrier properties. This method, along with strict attention to the cleanliness of the device, yielded very promising results. During the verification phase, devices encapsulated using this layered approach with strict attention to cleanliness performed well after going through thorough soak testing.
Rationality and related problems
Creators: name: Fusi, Davide
Publisher: name: University of Utah
Year: 2012
Subjects: Algebraic geometry
Rationality
Rational varieties
Rational degree

description: In this manuscript we discuss some problems regarding rational varieties. We study how rationality deforms in families giving a complete description for families of threefolds. We introduce a new invariant that can be attached to a rational variety and we study rational varieties for small values of the invariant. We discuss and we give a partial answer to the problem of determine if for every point on a rational variety we can  find a global system of parameters.
Gebirgsansicht vom Muttenwändli am Kistenpass 2546 mt : bey sehr starkem Föhn
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1877

description: IM
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Numerical investigation of pipe umbrella roof support systems in underground coal mining
Creators: name: Schumacher, Forrest Paul
Publisher: name: University of Utah
Year: 2012
Subjects: Directional drilling
Finite difference modeling
FLAC
Pipe umbrella
Roof support

description: Weak roof conditions in underground coal mines are a common occurrence and cause significant problems in delaying production. Thus, mine operators must look into additional support methods that reinforce the commonly used bolting, trussing, and cribbing methods. The work presented in this paper conceptualizes and models two methods of pipe umbrella roof support methods intended for employment in the underground coal mining environment. The first system is a pipe umbrella over a single entry of a development section. Secondly, a double layered pipe umbrella mesh is proposed as a reinforced roof over a longwall recovery room. Boreholes for such a configuration as the second system require precision placement and current state of the art technologies in horizontal directional drilling must be utilized. The design methodology was evaluated by examining a case study of a western U.S. coal mine and its specific geologic conditions. Geotechnical laboratory testing was performed for a weak sandstone channel material that occurs in large extents at the mine for input into numerical models. Two and three-dimensional finite difference models in Fast Lagrangian Analysis of Continua (FLAC) were developed and used as tools in the design of the pipe umbrella roof support methods proposed. One method utilizes beam elements embedded in the continuum model, while the other uses an equivalent modulus approach for modeling the reinforced zone. The effectiveness of a carefully designed pipe umbrella system is controlled by the pipe spacing, strength of the steel, and the structural geometry of the pipe. Numerical modeling of the reinforced roof shows that a reduction in recovery room closure can be achieved for the safe extraction of longwall support shields.
Gebirgsansicht gez. vom Quader ob Brigels : ca 7500' Höhe
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1874

description: IM.
description: Am unteren Blattrand links: "vom Robialp am Kistenpass herum über Quader nach Brigels statt [...] End d. Frisalthal hinunter zu steigen"
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Design, synthesis, anticancer evaluation, and molecular modelling studies of novel tolmetin derivatives as potential VEGFR-2 inhibitors and apoptosis inducers
Creators: name: Kassab, Asmaa E.
name: Gedawy, Ehab M.
name: Hamed, Mohammed I. A.
name: Doghish, Ahmed S.
name: Hassan, Rasha A.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Hematology

description: Novel tolmetin derivatives 5a–f to 8a–c were designed, synthesised, and evaluated for antiproliferative activity by NCI (USA) against a panel of 60 tumour cell lines. The cytotoxic activity of the most active tolmetin derivatives 5b and 5c was examined against HL-60, HCT-15, and UO-31 tumour cell lines. Compound 5b was found to be the most potent derivative against HL-60, HCT-15, and UO-31 cell lines with IC50 values of 10.32 ± 0.55, 6.62 ± 0.35, and 7.69 ± 0.41 µM, respectively. Molecular modelling studies of derivative 5b towards the VEGFR-2 active site were performed. Compound 5b displayed high inhibitory activity against VEGFR-2 (IC50 = 0.20 µM). It extremely reduced the HUVECs migration potential exhibiting deeply reduced wound healing patterns after 72 h. It induced apoptosis in HCT-15 cells (52.72-fold). This evidence was supported by an increase in the level of apoptotic caspases-3, -8, and -9 by 7.808-, 1.867-, and 7.622-fold, respectively. Compound 5b arrested the cell cycle in the G0/G1 phase. Furthermore, the ADME studies showed that compound 5b possessed promising pharmacokinetic properties.
Gebirgsansicht vom Punct 2590 neben und unter dem Kistenpassweg
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1876

description: Aussicht von Kistenpass gegen Urnerboden mit Muttenchopf und Nüschenstock sowie den Jegerstöck und dem Ortstock im linken Hintergrund
description: IM.
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Estimating active tension in cardiac micromuscles
Creators: name: Telle, Åshild
name: Charrez, Bérénice
name: Charwat, Verena
name: Finsberg, Henrik
name: Healy, Kevin E.
name: Wall, Samuel T.
Publisher: name: Zenodo
Year: 2022
Subjects: microphysiological system, micromuscles, cardiac mechanics, inverse problems, active strain, fiber direction estimation, computational biomechanics

description: Presentation at the World Congress on Biomechanics (WCB) - Taipei 2022.
Cyclocephala supernana Dechambre 1999
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala supernana

description: § Cyclocephala supernana Dechambre, 1999
Cyclocephala supernana Dechambre 1999: 17 (Venezuela (EO))
Distribution. Venezuela (EO): Dechambre 1999: 17 (EO); Moore et al. 2018b: 253 (EO).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 183, DOI: 10.5281/zenodo.3678492
Development of novel benzofuran-isatin conjugates as potential antiproliferative agents with apoptosis inducing mechanism in Colon cancer
Creators: name: Eldehna, Wagdy M.
name: Salem, Rofaida
name: Elsayed, Zainab M.
name: Al-Warhi, Tarfah
name: Knany, Hamada R.
name: Ayyad, Rezk R.
name: Bin Traiki, Thamer
name: Abdulla, Maha-Hamadien
name: Ahmad, Rehan
name: Abdel-Aziz, Hatem A.
name: El-Haggar, Radwan
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: In the current work, a new set of carbohydrazide linked benzofuran-isatin conjugates (5a–e and 7a–i) was designed and synthesised. The anticancer activity for compounds (5b–d, 7a, 7b, 7d and 7g) was measured against NCI-55 human cancer cell lines. Compound 5d was the most efficient, and thus subjected to the five-dose screen where it showed excellent broad activity against almost all tested cancer subpanels. Furthermore, all conjugates (5a–e and 7a–i) showed a good anti-proliferative activity towards colorectal cancer SW-620 and HT-29 cell lines, with an excellent inhibitory effect for compounds 5a and 5d (IC50 = 8.7 and 9.4 µM (5a), and 6.5 and 9.8 µM for (5d), respectively). Both compounds displayed selective cytotoxicity with good safety profile. In addition, both compounds provoked apoptosis in a dose dependent manner in SW-620 cells. Also, they significantly inhibited the anti-apoptotic Bcl2 protein expression and increased the cleaved PARP level that resulted in SW-620 cells apoptosis.
Techniques for optimizing neural networks for medical applications
Creators: name: Narus, Scott P.
Publisher: name: University of Utah
Year: 2012
Subjects: Neural Neworks (Computer)

description: The overwhelming amount and diversity of clinical data that may be collected from patients have necessitated the development and use of sophisticated processing methods in order to make the data useful in medical applications. Artificial neural networks (ANNs) are one such method that has found growing success in the medical field. In the past, techniques for optimizing neural networks have focused almost completely on ANN training algorithms and architectures in order to improve performance on specific applications. However, a more data-centric view of optimization may prove more valuable in making ANNs useful to a wider community of medical researchers. Four specific characteristics of medical data processing are addressed: (1) large numbers of classes into which we wish to categorize data; (2) nonuniform distribution of classes; (3) features from input data with non-Gaussian distributions and widely variable ranges; (4) large, complex data sets from which it is difficult to choose appropriate data for model development. These characteristics present potential problems for ANN development. It is proposed that these problems may be overcome by using new data normalization techniques, implementing hierarchical networks, and using distance metrics to choose the most useful training patterns. These proposals should be generalizable to many medical applications because they focus on solutions to data problems and not specific applications. The specific proposals are applied to two practical medical applications: blood pressure determination and classification of breathing circuit faults. The proposals are compared with standard ANN training techniques. For each of the proposals, there was a significant increase in training performance, or network classification capability, or both. It is concluded that the proposals should be generalizable to other medical applications and that a data-centric view of optimization is valuable to ANN development in medical applications.
Design, synthesis, and analysis of antiproliferative and apoptosis-inducing activities of nitrile derivatives containing a benzofuran scaffold: EGFR inhibition assay and molecular modelling study
Creators: name: Fares, Salma
name: Selim, Khalid B.
name: Goda, Fatma E.
name: El-Sayed, Magda A. A.
name: AlSaif, Nawaf A.
name: Hefnawy, Mohamed M.
name: Abdel-Aziz, Alaa A.-M.
name: El-Azab, Adel S.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: New cyanobenzofurans derivatives 2–12 were synthesised, and their antiproliferative activity was examined compared to doxorubicin and Afatinib (IC50 = 4.17–8.87 and 5.5–11.2 µM, respectively). Compounds 2 and 8 exhibited broad-spectrum activity against HePG2 (IC50 = 16.08–23.67 µM), HCT-116 (IC50 = 8.81–13.85 µM), and MCF-7 (IC50 = 8.36–17.28 µM) cell lines. Compounds 2, 3, 8, 10, and 11 were tested as EGFR-TK inhibitors to demonstrate their possible anti-tumour mechanism compared to gefitinib (IC50 = 0.90 µM). Compounds 2, 3, 10, and 11 displayed significant EGFR TK inhibitory activity with IC50 of 0.81–1.12 µM. Compounds 3 and 11 induced apoptosis at the Pre-G phase and cell cycle arrest at the G2/M phase. They also increased the level of caspase-3 by 5.7- and 7.3-fold, respectively. The molecular docking analysis of compounds 2, 3, 10, and 11 indicated that they could bind to the active site of EGFR TK.
Comparison of a personal sampling technique with a Six-Stage Andersen Cascade Impactor for viable bacterial aerosols in a mushroom plant
Creators: name: Marcinko, Robert James
Publisher: name: University of Utah
Year: 2012
Subjects: Air Sampling Apparatus
Microorganisms
Agricultural Workers

description: A personal sampling method employing the use of an MSA sampling pump and Gelman 0.8 micron membrane filter was compared with a Six Stage Andersen Cascade Impactor for sampling viable bacterial aerosols in a mushroom plant.  Four separate sets of samples were taken.  Included within each set of samples were eleven membrane filter samples taken simultaneously for ten minutes and two separate sixty second Andersen Impactor samples taken within the ten minute sampling period.  All samples were obtained at one location.  Microbial concentrations from the Gelman filters were determined by first placing the filter in a nutrient broth and suspending the collected organisms within the broth.  The suspension was then plated onto a nutrient agar medium and the resulting colonies counted.  The microbial concentrations from the Gelman filters were found to be quite variable within each sample set and were significantly different from the concentrations obtained with the Andersen Microbial Sampler.  A stong linear relationship was present when the mean values from the data groups for the two sampling methods were compared.  When comparing individual personal sampling method values with the mean values from the Andersen Microbial Sampler, a moderate to good linear relationship was found.
Gebirgsansicht aus meinem Zimmer im Gasthof von Elmer in Elm im Sernftal
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1876

description: IM.
description: Format unregelmässig
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
The effect of fatigue cracks on fastener flexibility, load distribution, and fatigue crack growth
Creators: name: Whitman, Zachary Layne
Publisher: name: University of Utah
Year: 2012
Subjects: Aircraft
Fatigue crack
Joint
Load distribution
Multifastener
Stress intensity

description: Fatigue cracks typically occur at stress risers such as geometry changes and holes. This type of failure has serious safety and economic repercussions affecting structures such as aircraft. The need to prevent catastrophic failure due to fatigue cracks and other discontinuities has led to durability and damage tolerant methodologies influencing the design of aircraft structures. Holes in a plate or sheet filled with a fastener are common fatigue critical locations in aircraft structure requiring damage tolerance analysis (DTA). Often, the fastener is transferring load which leads to a loading condition involving both far-field stresses such as tension and bending, and localized bearing at the hole. The difference between the bearing stress and the tensile field at the hole is known as load transfer. The ratio of load transfer as well as the magnitude of the stresses plays a significant part in how quickly a crack will progress to failure. Unfortunately, the determination of load transfer in a complex joint is far from trivial. Many methods exist in the open literature regarding the analysis of splices, doublers and attachment joints to determine individual fastener loads. These methods work well for static analyses but greater refinement is needed for crack growth analysis. The first fastener in a splice or joint is typically the most critical but different fastener flexibility equations will all give different results. The constraint of the fastener head and shop end, along with the type of fastener, affects the stiffness or flexibility of the fastener.
Design, synthesis, and in vitro evaluation of BP-1-102 analogs with modified hydrophobic fragments for STAT3 inhibition
Creators: name: Oleksak, Patrik
name: Psotka, Miroslav
name: Vancurova, Marketa
name: Sapega, Olena
name: Bieblova, Jana
name: Reinis, Milan
name: Rysanek, David
name: Mikyskova, Romana
name: Chalupova, Katarina
name: Malinak, David
name: Svobodova, Jana
name: Andrys, Rudolf
name: Rehulkova, Helena
name: Skopek, Vojtech
name: Lam, Pham Ngoc
name: Bartek, Jiri
name: Hodny, Zdenek
name: Musilek, Kamil
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Twelve novel analogs of STAT3 inhibitor BP-1-102 were designed and synthesised with the aim to modify hydrophobic fragments of the molecules that are important for interaction with the STAT3 SH2 domain. The cytotoxic activity of the reference and novel compounds was evaluated using several human and two mouse cancer cell lines. BP-1-102 and its two analogs emerged as effective cytotoxic agents and were further tested in additional six human and two murine cancer cell lines, in all of which they manifested the cytotoxic effect in a micromolar range. Reference compound S3I-201.1066 was found ineffective in all tested cell lines, in contrast to formerly published data. The ability of selected BP-1-102 analogs to induce apoptosis and inhibition of STAT3 receptor-mediated phosphorylation was confirmed. The structure–activity relationship confirmed a demand for two hydrophobic substituents, i.e. the pentafluorophenyl moiety and another spatially bulky moiety, for effective cytotoxic activity and STAT3 inhibition.
Foostöckli und Foostock : gezeichnet vom Fahnen ob der Mittleren Camperdun Alp
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1876

description: IM.
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Physiological changes in the heart rate, respiratory rate, blood pressure and peripheral blood flow in low birth wight premature infants following oral gavage feedings
Creators: name: Isaacs, Patricia Cima
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Infant Nutrition
subject: Nursing
subject: FOS: Health sciences

description: Preterm infants demonstrate physiologic instability during handling. The purpose of this study was to describe physiologic changes that occur before transfer, during transfer, and after transfer of the premature intubated and mechanically ventilated very-low-birth-weight (VLBW) infant. A secondary analysis of previously acquired data from an experimental study of 14 ventilated VLBW infants during skin-to-skin (SSC) holding was conducted. The results of this study reveal that the preparation for transfer and the transfer are physiologically stressful to the premature intubated VLBW. Minimizing nursing-care activities, excessive handling, and transfer of these infants until they are more stable or mature may be more favorable for their growth and welfare.
Gezeichnet vom Ochsenstock bey Richisau
Creators: name: Heim, Albert
Publisher: name: [s.n.]
Year: 1875

description: Aussicht vom Ochsenchopf nordwestlich des Klöntalersees Richtung Galenstock, Spannort, Titlis, Urirothstock und Drusberg
description: A. Heim ; (Copie)
description: Umschlag: gefaltete Bleistiftzeichnung mit Berggipfel: Zeichnung gegen Innen und aussen beschriftet mit "vom Ochsenstock bey Richisau"
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Cyclocephala testacea Burmeister 1847
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala testacea

description: Cyclocephala testacea Burmeister, 1847
Cyclocephala testacea Burmeister 1847: 57 (French Guiana)
Distribution. Guyana: Moore et al. 2018b: 254. Suriname: Moore et al. 2018b: 254; MHCN - NEW COUNTRY RECORD (Suriname, Sipaliwini, Arapahu Resort, (3°27′N, 57°37.5′W). 1/ 7-III-2011. A. J. Hielkema. On UV/HPL in forest.); NZCS. French Guiana: Burmeister 1847: 57; Brûlé et al. 2011a: 191, 2014: 182; Duranton 2011: 16; Ponchel 2011: 60; Dupuis 2016b: 109; Moore et al. 2018b: 254; MHCN. “Guianas”: Arrow 1937b: 16; Blackwelder 1944: 253. Brazil (NA): Andreazze and Fonseca 1998: 61 (NA); Moore et al. 2018b: 254 (NA). Venezuela: Blackwelder 1944: 253; Moore et al. 2018b: 254. Other: Blackwelder 1944: 253 (Argentina); Endrödi 1966a: 318 (treated as an abberation of C. ovulum), 1985a: 113, 142 (treated as an abberation of C. ovulum); Moore et al. 2018b: 254 (Argentina, Bolivia, Colombia, Ecuador, Paraguay, Peru, Uruguay).
Note. Endrödi (1966a: 318, 1985a: 113, 142) considers Cyclocephala testacea as an abberation of C. ovulum. The records of C. testacea for Suriname and Guyana in Moore et al. (2018b: 254) are copied from Endrödi (1966: 318) and therefore cannot be trusted. As we are unaware of any valid reports of this species for Suriname, we consider our own finding of this species in Suriname a new country record. The species remains unrecorded for Guyana.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 183, DOI: 10.5281/zenodo.3678492
Cyclocephala tidula Dechambre 1999
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala tidula

description: § Cyclocephala tidula Dechambre, 1999
Cyclocephala tidula Dechambre 1999: 18 (Venezuela (EO))
Distribution. Venezuela (EO): Dechambre 1999: 18 (EO); Moore et al. 2018b: 255 (EO).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 184, DOI: 10.5281/zenodo.3678492
The effects of adrenal corticosteroids on oxygen utilization in rats
Creators: name: Roosevelt, Theodore Steven
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Anatomy

description: 1. Sham-adrenalectomized and cortisol injected adrenalectomized rats survived exposure to a hypoxic (5% oxygen) atmosphere significantly longer than did adrenalectomized control rats.  2. The difference in survival times between rates with and without corticosteroids was not due to the absence of the adrenal medulla since sham-hypophysectomized rats' survived exposure to a hypoxic (5% oxygen) atmosphere significantly longer did hypophysectomized.  3. Rats, with and without adrenal corticosteroids, when exposed to a 5% oxygen atmosphere for one hour showed significant elevation in blood lactic acid concentration.  More significant, however, was the findings that rats with adrenal corticosteroids had significantly lower levels of blood lactic acid under hypoxic conditions than those without.  4. Cortisol treatment of adrenalectomized rats produce a significant elevation of cerebral cortical mitrochondrial state 3 respiration, respiratory control ration and ADP:0 ratio when NAD-linked substrates were used.  Succinate, a substrate not linked to NAD, showed non-rate limiting decrease in state 3 respiration and respiratory control ratio after cortisol treatment.  Cycloheximide and Actinomycin D had no effect on these parameters of mitochondrial respiration, but were capable of blocking cortisol induced changes.  5. The rotenone sensitive factor of the NADH dehydrogenase complex was elevated by cortisol treatment from 0.09 to 0.14 nmoles/mg protein.  The cytochrome content of the mitochondrial respiratory chain was not altered by corticosteroids, suggesting that the cortisol induces increases in state e respiration and respiratory control ratio with NAD-linked substrate are due to an increase in the concentration of the rotenone sensitive factor.
They dynamics of interagency collaborations: a three-part framework
Creators: name: Tellesbo, Sarah Marie
Publisher: name: University of Utah
Year: 2013
Subjects: Interagency Collaboration
Management
Networks
Organizational Behavior
Public Administration
Social Services

description: Social problems are complex, increasingly so, yet resources allocated to deal with these problems have declined. Nonprofit and government agencies tasked with providing social services to individuals are joining forces to solve the most complicated problems faced by society. The Palmer Court Employment Pilot in Salt Lake City, Utah is an example of one such nonprofit/government collaboration. In a yearlong case study analysis, data from the Palmer Court Employment Pilot were collected and analyzed to reveal both strengths and weaknesses of the collaborative approach. The reported findings, in combination with a synthesis of previous literature, serve as a foundation for a ternary framework of interagency collaboration focusing on: (1) cultural dynamics, (2) relational dynamics, and (3) practical dynamics. The theory posited serves as a starting point for further research on the intersection of nonprofit/government collaboration.
Novel mechanisms of two death domain proteins and the development of a single-cell assay for caspase activity in living cells
Creators: name: Morgan, Michael Joseph
Publisher: name: University of Utah
Year: 2012
Subjects: Death Domain Proteins
Single-Cell Assay
Caspase
Apoptosis
Cell Termination
FADD Adapter
Molecular Biology
Cellular Biology
Oncology

description: Apoptosis, or programmed cell death (PCD), is a cell-intrinsic, genetically directed system of cell termination that is important in a wide range of physiological and pathological processes. Apoptotic signals conducted through death receptors are important in inflammation, autoimmunity, and organ development and degeneration. Adapter proteins with death domains, such as FADD and TRADD, play a critical role in pathways activated by Fas and TNF-R1 through the recruitment and activation of caspases. The basic model describing Fas and TNF-receptor mediated cell death consists of linear pathways from ligand to caspases. Studies have continued to show that these pathways are the principal mechanism by which death receptors initiate the apoptotic process. However, a number of other signals that are initiated by death receptors may play important roles within different cellular contexts. In addition, caspase inhibition fails to stop death initiated by death receptors, suggesting that both caspase-dependent and caspase-independent pathways are activated by the receptor. These pathways likely involve death domain proteins, including TRADD and FADD. This treatise describes novel behaviors of the isolated death domains of FADD and TRADD. The death domain of FADD (FADD-DN) usually acts as to block apoptosis. However, in primary prostate epithelial cells, it initiates cell death. This effect appears to be both tissue- and cell-type-specific in that prostate tumor cell lines, primary prostate tumor cells, and normal primary prostate stromal cells fail to die similarly. A new assay for caspase activation in living, single cells, which utilizes fluorescence resonance energy transfer (FRET), is described and is used to show that caspase activation occurs in these cells in response to FADD-DN. The isolated death domain of TRADD also has a novel behavior in that it localizes in "dot-like" structures in the nucleus. In addition, the mechanism of death induced by nuclear TRADD appears to be distinct from its function at the cell membrane in that death is not blocked with FADD-DN, but is inhibited by Bcl-xL. In the novel behaviors described herein, both FADD and TRADD appear to activate caspase-dependent and independent processes distinct from ones previously described.
Zadmehr Torabi - The Persian Whitman beyond a literary reception
Creators: name: Fomeshi, Behnam
Publisher: name: figshare
Year: 2020
Subjects: subject: 210104 Archaeology of Australia (excl. Aboriginal and Torres Strait Islander)
subject: FOS: History and archaeology
subject: Literature

description: A review of the Persian Whitman by Zadmehr Torabi published in British Journal of Middle Eastern Studies
Tödi : durch Fernrohr gezeichnet auf Schiahorn bey Davos 8200'
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1862

description: [Johann Müller-Wegmann]
description: Format unregelmässig
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
New benzothieno[2,3-c]pyridines as non-steroidal CYP17 inhibitors: design, synthesis, anticancer screening, apoptosis induction, and in silico ADME profile studies
Creators: name: Khalil, Nadia A.
name: Ahmed, Eman M.
name: Zaher, Ashraf F.
name: Sobh, Eman A.
name: El-Sebaey, Samiha A.
name: El-Zoghbi, Mona S.
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: A series of [1]benzothieno[2,3-c]pyridines was synthesised. Most compounds were chosen by NCI-USA to evaluate their anticancer activity. Compounds 5a–c showed prominent growth inhibition against most cell lines. 5c was selected at five dose concentration levels. It exhibited potent broad-spectrum anticancer activity with a GI50 of 4 nM–37 µM. Cytotoxicity of 5a–c was further evaluated against prostate, renal, and breast cancer cell lines. 5c showed double and quadruple the activity of staurosporine and abiraterone, respectively, against the PC-3 cell line with IC50 2.08 µM. The possible mechanism of anti-prostate cancer was explored via measuring the CYP17 enzyme activity in mice prostate cancer models compared to abiraterone. The results revealed that 5c suppressed the CYP17 enzyme to 15.80 nM. Moreover, it was found to be equipotent to abiraterone in testosterone production. Cell cycle analysis and apoptosis were performed. Additionally, the ADME profile of compound 5c demonstrated both good oral bioavailability and metabolic stability.
Tödi von Schwanden : gez. bey der Kirche
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1876

description: IM ; Blattengrat: bey Engi im Sernftal gez.
description: Format unregelmässig
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC
Cyclocephala toulgoeti Dechambre 1992
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala toulgoeti

description: Cyclocephala toulgoeti Dechambre, 1992
Cyclocephala toulgoeti Dechambre 1992: 60 (French Guiaina)
Distribution. French Guiana: Dechambre 1992: 60; Brûlé et al. 2011a: 191, 2014: 182 (as C. tougoeti [sic]); Duranton 2011: 16; Ponchel 2011: 60; Brûlé and Dalens 2012a annex 4: 18; Dupuis 2016b: 109; Moore et al. 2018b: 255; MHCN.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 184, DOI: 10.5281/zenodo.3678492
Degradable hydrogels for colon-specific oral delivery of peptides and proteins
Creators: name: Yeh, Ping-Yang
Publisher: name: University of Utah
Year: 2012
Subjects: Protein Drugs
Pharmacology

description: Novel pH sensitive hydrogels containing azoaromatic crosslinks were synthesized by the crosslinking of polymeric precursors. First, a reactive polymeric precursor was synthesized by copolymerization of N,N-dimethylacrylamide, N-tert.-butylacrylamide, acrylic acid, and N-methacryloylglycylglycine p-nitrophenyl ester. The hydrogel was prepared in the second step by the reaction of the polymeric precursor with N,N'-(omega-aminocaproyl)-4,4'-diaminoazobenzene. These hydrogels are suitable for colon-specific peptide or protein delivery. In the low pH range of the stomach, the swelling of the gel is low and the drug is protected against digestion by enzymes. In the small intestine, the swelling increases. Upon arrival in the colon, a degree of swelling is reached that makes the crosslinks accessible to azoreductase activity. The gel is degraded and drug released.  The hydrogels were characterized by the network structure (i.e., content of crosslinks, unreacted pendent groups, and cycles), the equilibrium and dynamic swelling as a function of pH, modulus of elasticity, and in vitro/ in vivo degradation. The results indicated that the hydrogel network structure strongly depends on the reaction conditions such as polymer concentration, and the ratio of the reactive groups during the crosslinking reaction. The swelling and mechanical properties of hydrogels can be controlled by the modification of polymer backbone structure and/or the crosslinking density. Depending on the network structure, the degradation of hydrogels followed either a surface erosion or a bulk-degradation-like process. In vivo degradation rate of hydrogels was three to five times faster than that of in vitro, indicating a higher azoreductase activity in vivo.  A gel-coated capsule device was formulated for the oral delivery of insulin. Its mechanical properties and the rate of insulin release were found to be related to the degree of swelling of the coated gel layers. The higher the swelling, the higher the amount of insulin released, and the weaker the mechanical strength of the coated capsule.  Effect of a penetration enhancer, namely of CapMul MCM (a medium chain glyceride) on physiological properties of rabbit intestinal epithelium was investigated in vitro using the Ussing chamber technique. It was shown that CapMul MCM affected tissue ion transport, permeability, and morphology in a concentration and time-dependent manner. It was found that with minimal epithelial disruption and moderate change in ion transport in the colon, the increase in marker molecule permeabilities ranged between 7-25 times depending upon their molecular weight.
Latency, thermal stability, and identification of an inhibitory compound of mirolysin, a secretory protease of the human periodontopathogen Tannerella forsythia
Creators: name: Zak, Krzysztof M.
name: Bostock, Mark J.
name: Waligorska, Irena
name: Thøgersen, Ida B.
name: Enghild, Jan J.
name: Popowicz, Grzegorz M.
name: Grudnik, Przemyslaw
name: Potempa, Jan
name: Ksiazek, Miroslaw
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Mirolysin is a secretory protease of Tannerella forsythia, a member of the dysbiotic oral microbiota responsible for periodontitis. In this study, we show that mirolysin latency is achieved by a “cysteine-switch” mechanism exerted by Cys23 in the N-terminal profragment. Mutation of Cys23 shortened the time needed for activation of the zymogen from several days to 5 min. The mutation also decreased the thermal stability and autoproteolysis resistance of promirolysin. Mature mirolysin is a thermophilic enzyme and shows optimal activity at 65 °C. Through NMR-based fragment screening, we identified a small molecule (compound (cpd) 9) that blocks promirolysin maturation and functions as a competitive inhibitor (Ki = 3.2 µM), binding to the S1′ subsite of the substrate-binding pocket. Cpd 9 shows superior specificity and does not interact with other T. forsythia proteases or Lys/Arg-specific proteases.
Static Multiple Light Scattering (SMLS)
Creators: name: Hutin, Anthony
Publisher: name: Zenodo
Year: 2022
Subjects: Static Multiple Light Scattering
Creaming
Sedimentation
Coalescence
Stability
Particles
Foams
Emulsions

description: Issue:
 - What is Static Multiple Light Scattering (SMLS)?
 - How to use SMLS to study instability phenomena of dispersions?

 Contents:
 - SMLS principle
 - Study of migration phenomena: creaming and sedimentation
 - Study of size increase: flocculation, coalescence, and ripening
 - Measurement limits

 Static Multiple Light Scattering (SMLS) is an optical method to directly characterize concentrated liquid dispersions in their native state. Many emulsions or suspensions are used in concentrated form. Optical methods such as laser diffraction (SLS) or dynamic light scattering (DLS) offer limited possibilities in terms of analysis of such formulations. In addition, concentrated products have to be diluted and therefore mixed (mechanical stress) which changes the dispersion state. SMLS can be used to characterized the dispersions without dilution or change of the initial state.
Obsidian Procurement and Exchange at the Apogee of Empire: Wari Political Economy in Arequipa, Peru
Creators: name: Reid, David
name: Williams, Patrick Ryan
name: Cardona Rosas, Augusto
name: Coleman Goldstein, Robin
name: Dussubieux, Laure
name: Banikazemi, Cyrus
name: Rademaker, Kurt
Publisher: name: University of Illinois at Chicago
Year: 2024
Subjects: classificationCode: 43
subject: History, heritage and archaeology
classificationCode: 37
subject: Earth sciences

description: During the Middle Horizon (AD 600–1000), obsidian was transported in greater quantities and distances than ever before identified in the Andes, in part by the expansionary Wari state. Two of the three major obsidian sources used in the south-central Andes are located in the modern department of Arequipa, Peru. Arequipa was a region of intense Wari influence and intrusive presence; however, little is known about regional obsidian use. Portable X-ray fluorescence (pXRF) and laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) were used to analyze 383 obsidian artifacts recovered from 10 archaeological sites in Arequipa. Results highlight diachronic and spatial patterning related to obsidian procurement strategies, state versus bottom-up exchange networks, and local participation within the Wari realm. A wide variety of geological obsidian sources, including nonlocal obsidians originating from Wari’s Ayacucho heartland, were used. By the late Middle Horizon, the Wari had consolidated regional resources with the sole use of Alca-1 and Alca-4 bedrock obsidians, the largest-sized and highest-quality sources in the area. We assess related models of obsidian procurement and exchange related to state political economy, long-distance caravan activity, and the role of local ceremonial/waystation centers that facilitated the flow of ideas, goods, and people across Arequipa.
Inhibitors of histone deacetylase 6 based on a novel 3-hydroxy-isoxazole zinc binding group
Creators: name: Linciano, Pasquale
name: Pinzi, Luca
name: Belluti, Silvia
name: Chianese, Ugo
name: Benedetti, Rosaria
name: Moi, Davide
name: Altucci, Lucia
name: Franchini, Silvia
name: Imbriano, Carol
name: Sorbi, Claudia
name: Rastelli, Giulio
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Histone deacetylase 6 (HDAC6) is an established drug target for cancer treatment. Inhibitors of HDAC6 based on a hydroxamic acid zinc binding group (ZBG) are often associated with undesirable side effects. Herein, we describe the identification of HDAC6 inhibitors based on a completely new 3-hydroxy-isoxazole ZBG. A series of derivatives decorated with different aromatic or heteroaromatic linkers, and various cap groups were synthesised and biologically tested. In vitro tests demonstrated that some compounds are able to inhibit HDAC6 with good potency, the best candidate reaching an IC50 of 700 nM. Such good potency obtained with a completely new ZBG make these compounds particularly attractive. The effect of the most active inhibitors on the acetylation levels of histone H3 and α- tubulin and their anti-proliferative activity of DU145 cells were also investigated. Docking studies were performed to evaluate the binding mode of these new derivatives and discuss structure-activity relationships.
Using microsimulation to evaluate traffic incident responses for traffic operations center decision making
Creators: name: Tasic, Ivana
Publisher: name: University of Utah
Year: 2012
Subjects: Microsimulation
Traffic incident responses
Traffic operations centers

description: One of the major challenges for Traffic Operations Center (TOC) operators is to determine the nature of their response to traffic incidents. This applies to both operators' training and real traffic management. While incidents vary by location and degree of disruption, operators' responses vary by how quickly they are implemented and what degree of actions they take. Operators can react instantaneously and divert traffic from an entire highway, or simply wait and apply a mild variable message. Travelers' delay under incident conditions depends not only on incident severity, but also on the effectiveness of response to an incident. This is an analysis of a wide range of incidents and responses for the set of critical locations on a test Salt Lake Valley freeway network. It uses VISSIM microsimulation to determine optimal responses under various incident conditions. Incident severity is represented through Incident Location, Incident Duration and Lane Closure. Incident response is defined through the Response Time, and Variable Message Sign (VMS) Levels and VMS Display Time. As expected, the resulting degree of incident disruption is mitigated by the speed of response and the proportion of drivers who divert. However, for certain minor incidents, a VMS induced traffic diversion might increase travelers' delay instead of reducing it.
Cyclocephala tridentata
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala tridentata

description: § Cyclocephala tridentata (Fabricius, 1801)
Melolontha tridentata Fabricius 1801b: 170 (Guadeloupe)
= Cyclocephala tridentata dominicensis Cartwright and Chalumeau 1978: 25 (Dominica) - Ratcliffe and Cave 2015: 113 (syn. nov.)
= Cyclocephala annamariae Dutrillaux et al. 2013: 64 (Martinique) - Ratcliffe and Cave 2015: 113 (syn. nov.)
Distribution. Suriname: Endrödi 1966a: 321, 1985a: 99, 138; Moore et al. 2018b: 255. Other: Fabricius 1801b: 170 (Guadeloupe - as Melolontha tridentata); Arrow 1937b: 16 (Guadeloupe, Martinique); Blackwelder 1944: 253 (Dominica, Guadeloupe, Martinique); Endrödi 1966a: 321 (Barbados, Colombia, Dominican Republic [> Dominica!], Guadeloupe, Martinique), 1985a: 99, 138 (Barbados, Colombia, Dominica, Guadeloupe, Martinique); Cartwright and Chalumeau 1978: 25 (Dominica - as C. tridentata dominicensis); Ponchel 2011 (not mentioned); Dutrillaux et al. 2013: 64 (Martinique - as C. annamariae; Dominica - as C. dominicensis; Guadeloupe - as C. tridentata); Dupuis 2016b (not mentioned); Moore et al. 2018b: 255 (Colombia, West Indies).
Note 1. Dutrillaux et al. (2013) split the populations of Cyclocephala tridentata from the islands of Martinique, Dominica and Guadeloupe (Lesser Antilles) into C. tridentata (Guadeloupe), C. dominicensis (was C. tridentata dominicensis Cartwright and Chalumeau, 1978 (p. 25)) (Dominica) and C. annamariae (Martinique) based on differences in their mitochondrial gene CO1. The publication does not include information regarding mainland specimens. Ratcliffe and Cave (2015: 113) reduce C. dominicensis and C. annamariae to synonyms of C. tridentata. The authors and year of description of C. tridentata dominicensis are discussed in Ratcliffe and Cave (2015: 116).
Note 2. Endrödi (1966a: 321, 1985a: 99, 138) records Cyclocephala tridentata for Suriname and Colombia, and these records are repeated in Moore et al. (2018b: 255). Ratcliffe and Cave (2015: 114) mention they have not seen specimens from Suriname or Colombia. There are also no other records for the mainland of South America that we are aware of, and it may well be that Endrödi’s record for Suriname is based on a mislabeled or misidentified specimen. We regard this species as not occurring in the research area.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 184, DOI: 10.5281/zenodo.3678492
Olympia G. Antoniadou - The Persian Whitman Beyond a Literary Reception
Creators: name: Fomeshi, Behnam
Publisher: name: figshare
Year: 2020
Subjects: Literature

description: A review of The Persian Whitman in Greek by Olympia G. Antoniadou published in COMPARISON/COMPARAISON: A Journal of the Greek General and Comparative Literature Association
Eckstöck von Linthal
Creators: name: Müller, Johann
Publisher: name: [s.n.]
Year: 1877

description: [Johann Müller-Wegmann] ; Unter Baumgarten Alp 1601 m: gez v Fritten Ort Staffel
description: Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SAC