cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: ADCO, Premier cartulaire de l'abbaye de Molesmes (XIIe siècle), Cart. 142 (7 H 6), 128 pages, f. 0020r
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2009
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire

description: Premier cartulaire de l'abbaye de Molesmes (XIIe siècle), Archives départementales de la Côte-d'Or, Cart. 142 (7 H 6), 128 pages, f. 0020r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Premier cartulaire de l'abbaye de Molesmes (XIIe siècle), Archives départementales de la Côte-d'Or, Cart. 142 (7 H 6), 128 pages, f. 0020r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb137389344
description: Provenance: abbaye de Molesme
description: Provenance: http://www.wikidata.org/entity/Q334044
Additional file 1: of Effects of perioperative fluid management on postoperative outcomes in liver transplantation: a systematic review protocol
Creators: name: Carrier, FranĂ§ois
name: ChassĂŠ, MichaĂŤl
name: Wang, Han
name: Aslanian, Pierre
name: Bilodeau, Marc
name: Turgeon, Alexis
Publisher: name: figshare
Year: 2018
Subjects: Medicine
Science Policy
Computational Biology

description: PRISMA-P 2015 Checklist. (PDF 5108 kb)
Danicopan: First Approval
Creators: name: Kang, Connie
Publisher: name: Adis Journals
Year: 2024
Subjects: Medicine

description:   
Declarations
Funding The preparation of this review was not supported by any external funding.
Authorship and Conflict of interest During the peer review process the manufacturer of the agent under review was offered an opportunity to comment on the article. Changes resulting from any comments received were made by the authors on the basis of scientific completeness and accuracy. Connie Kang is a salaried employee of Adis International Ltd/Springer Nature, and declares no relevant conflicts of interest. All authors contributed to this article and are responsible for its content.
Ethics approval, Consent to participate, Consent to publish, Availability of data and material, Code availability Not applicable.

Additional information about this Adis Drug Review can be found here.

  
Abstract 
Danicopan (Voydeya®) is an oral complement factor D inhibitor that is being developed by Alexion AstraZeneca Rare Disease as add-on treatment to ravulizumab or eculizumab for patients with clinically significant extravascular haemolysis. Danicopan recently received approval in Japan for the treatment of adults with paroxysmal nocturnal haemoglobinuria (PNH) when used in addition to a complement component 5 (C5) inhibitor. Subsequently, the European Medicines Agency adopted a positive opinion recommending the granting of marketing authorisation for danicopan for the treatment of patients with PNH who continue to have residual haemolytic anaemia despite treatment with a complement C5 inhibitor. This article summarizes the milestones in the development of danicopan leading to this first approval for PNH.

© Springer Nature Switzerland AG 2024
Additional file 3: of Effects of perioperative fluid management on postoperative outcomes in liver transplantation: a systematic review protocol
Creators: name: Carrier, FranĂ§ois
name: ChassĂŠ, MichaĂŤl
name: Wang, Han
name: Aslanian, Pierre
name: Bilodeau, Marc
name: Turgeon, Alexis
Publisher: name: figshare
Year: 2018
Subjects: Medicine
Chemical Sciences not elsewhere classified
Developmental Biology
Science Policy

description: Data extraction form. (DOCX 81 kb)
Content-Based Video Retrieval in Historical Collections of the German Broadcasting Archive
Creators: name: Mühling, Markus
name: Meister, Manja
name: Korfhage, Nikolaus
name: Wehling, Jörg
name: Hörth, Angelika
name: Ewerth, Ralph
name: Freisleben, Bernd
Publisher: name: arXiv
Year: 2017
Subjects: subject: Digital Libraries (cs.DL)
subject: Multimedia (cs.MM)
subject: FOS: Computer and information sciences

description: The German Broadcasting Archive (DRA) maintains the cultural heritage of radio and television broadcasts of the former German Democratic Republic (GDR). The uniqueness and importance of the video material stimulates a large scientific interest in the video content. In this paper, we present an automatic video analysis and retrieval system for searching in historical collections of GDR television recordings. It consists of video analysis algorithms for shot boundary detection, concept classification, person recognition, text recognition and similarity search. The performance of the system is evaluated from a technical and an archival perspective on 2,500 hours of GDR television recordings.
description: TPDL 2016, Hannover, Germany. Final version is available at Springer via DOI
A dual glycoengineering system: combining synthetic biology with an artificial Golgi column
Creators: name: DeBono, Nicholas
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Glycoengineering aims to generate proteins with defined glycosylation. Production of glycoengineered proteins can be performed in vivo, with modification of gene expression of the host glycosylation enzymes pre-protein purification, or in vitro, using glycan modifying enzymes post-protein purification. Glycoengineering in vivo is scalable but requires the combinatorial generation of genetic variants. Glycoengineering in vitro is more controllable but increases in cost as number of enzymes involved increases. Here a dual glycoengineering system, comprising of an in vivo glycoengineered Saccharomyces cerevisiae and an artificial Golgi column (AGC) was designed. When glycoengineered high-yield producing yeast was coupled to an in vitro glycosylating column, a scalable, glycan-defined glycoprotein production system was created. A target glycoprotein (Trastuzumab) is produced in S. cerevisiae engineered to synthesize the GlcNAcMan5GlcNAc2 hybrid glycan structure by disrupting genes OCH1 and MNN1, while inserting α-1,2-mannosidase and GnTI into the genome. Subsequently, the AGC performs in vitro glycosylation with immobilised B4GalT1 and ST6Gal1 on-column, forming galactosylated and sialylated glycans. Physical parameters such as flowrate and substrate concentrations were partially optimised for on-column glycosylation and the reusability of the column was demonstrated. This multi-faceted approach to glycoengineering shows promise for future industrial applications with potential for large-scale glycan modification of valuable therapeutics and glycoproteins -- abstract.
Multiplication and Presence of Shielding Material from Time-Correlated Pulse-Height Measurements of Subcritical Plutonium Assemblies
Creators: name: Monterial, Mateusz
name: Marleau, Peter
name: Paff, Marc
name: Clarke, Shaun
name: Pozzi, Sara
Publisher: name: arXiv
Year: 2017
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Data Analysis, Statistics and Probability (physics.data-an)
subject: FOS: Physical sciences

description: We present the results from the first measurements of the Time-Correlated Pulse-Height (TCPH) distributions from 4.5 kg sphere of $α$-phase weapons-grade plutonium metal in five configurations: bare, reflected by 1.27 cm and 2.54 cm of tungsten, and 2.54 cm and 7.62 cm of polyethylene. A new method for characterizing source multiplication and shielding configuration is also demonstrated. The method relies on solving for the underlying fission chain timing distribution that drives the spreading of the measured TCPH distribution. We found that a gamma distribution fits the fission chain timing distribution well and that the fit parameters correlate with both multiplication (rate parameter) and shielding material types (shape parameter). The source-to-detector distance was another free parameter that we were able to optimize, and proved to be the most well constrained parameter. MCNPX-PoliMi simulations were used to complement the measurements and help illustrate trends in these parameters and their relation to multiplication and the amount and type of material coupled to the subcritical assembly.
description: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Spin-wave dynamics in Permalloy/Cobalt magnonic crystals in the presence of a non-magnetic spacer
Creators: name: Malago, P.
name: Giovannini, L.
name: Zivieri, R.
name: Gruszecki, P.
name: Krawczyk, M.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: In this paper, we theoretically study the influence of a non-magnetic spacer between ferromagnetic dots and ferromagnetic matrix on the frequency dispersion of the spin wave excitations in two-dimensional bi-component magnonic crystals. By means of the dynamical matrix method we investigate structures inhomogeneous across the thickness represented by square arrays of Cobalt or Permalloy dots in a Permalloy matrix. We show that the introduction of a non-magnetic spacer significantly modifies the total internal magnetic field especially at the edges of the grooves and dots. This permits the manipulation of the magnonic band structure of spin waves localized either at the edges of the dots or in matrix material at the edges of grooves. According to the micromagnetic simulations two types of end modes were found. The corresponding frequencies are significantly influenced by the end modes localization region. We also show that, with the use of a single ferromagnetic material, it is possible to design a magnonic crystal preserving properties of bi-component magnonic crystals and magnonic antidot lattices. Finally, the influence of the non-magnetic spacers on the technologically relevant parameters like group velocity and magnonic band width are discussed.
description: 18 pages, 5 figures
Additional file 1: of Canary: an atomic pipeline for clinical amplicon assays
Creators: name: Doig, Kenneth
name: Ellul, Jason
name: Fellowes, Andrew
name: Thompson, Ella
name: Ryland, Georgina
name: Blombery, Piers
name: Papenfuss, Anthony
name: Fox, Stephen
Publisher: name: figshare
Year: 2017
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: canary usage.docx: Description of the Canary command line options. (DOCX 136Â kb)
MPEC 2024-U195 : 2024 UG6
Creators: name: Minor Planet Center Staff
Publisher: name: The Minor Planet Center
Year: 2024
Subjects: subject: Small Solar System bodies
valueUri: http://astrothesaurus.org/uat/1469
subject: 2024 UG6

description: The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements.  They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
title: Good Things Come to Those Who Wait?: The Joint Reconciliation Declaration of Germany and Namibia for the Herero and Nama Genocide
Creators: name: Wissmann, Sara
name: Adler, Julius
Publisher: name: Fachinformationsdienst für internationale und interdisziplinäre Rechtsforschung
Year: 2021
Subjects: subject: 341

description: German Yearbook of International Law, vol. 64, no. 1, p. 511
title: The Spanish Amnesty, the Conflict with Catalonia, and the Rule of Law
Creators: name: Casals, Neus Torbisco
name: Krisch, Nico
Publisher: name: Fachinformationsdienst für internationale und interdisziplinäre Rechtsforschung
Year: 2024
Subjects: subject: 342

description: Verfassungsblog: On Matters Constitutional
Sparsity-Sensitive Finite Abstraction
Creators: name: Gruber, Felix
name: Kim, Eric S.
name: Arcak, Murat
Publisher: name: arXiv
Year: 2017
Subjects: subject: Systems and Control (eess.SY)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Abstraction of a continuous-space model into a finite state and input dynamical model is a key step in formal controller synthesis tools. To date, these software tools have been limited to systems of modest size (typically $\leq$ 6 dimensions) because the abstraction procedure suffers from an exponential runtime with respect to the sum of state and input dimensions. We present a simple modification to the abstraction algorithm that dramatically reduces the computation time for systems exhibiting a sparse interconnection structure. This modified procedure recovers the same abstraction as the one computed by a brute force algorithm that disregards the sparsity. Examples highlight speed-ups from existing benchmarks in the literature, synthesis of a safety supervisory controller for a 12-dimensional and abstraction of a 51-dimensional vehicular traffic network.
Additional file 1 of Spread of the florfenicol resistance floR gene among clinical Klebsiella pneumoniae isolates in China
Creators: name: Lu, Junwan
name: Zhang, Jinfang
name: Xu, Lei
name: Liu, Yabo
name: Li, Pingping
name: Zhu, Tingyuan
name: Cheng, Cong
name: Lu, Shunfei
name: Xu, Teng
name: Yi, Huiguang
name: Li, Kewei
name: Zhou, Wu
name: Li, Peizhen
name: Ni, Liyan
name: Bao, Qiyu
Publisher: name: figshare
Year: 2023
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics

description: Table S1 Grouping of 105 floR gene containing sequences and their origins. (PDF 67 kb)
Spatial heterogeneity of W transmutation in a fusion device
Creators: name: Gilbert, M. R.
name: Sublet, J. -Ch.
name: Dudarev, S. L.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Accurately quantifying the transmutation rate of tungsten (W) under neutron irradiation is a necessary requirement in the assessment of its performance as an armour material in a fusion power plant. The usual approach of calculating average responses, assuming large, homogenised material volumes, is insufficient to capture the full complexity of the transmutation picture in the context of a realistic fusion power plant design, particularly for rhenium (Re) production from W. Combined neutron transport and inventory simulations for representative {\it spatially heterogeneous} models of a fusion power plant show that the production rate of Re is strongly influenced by the local spatial environment. Localised variation in neutron moderation (slowing down) due to structural steel and coolant, particularly water, can dramatically increase Re production because of the huge cross sections of giant resolved resonances in the neutron-capture reaction of \(^{186}\)W at low neutron energies. Calculations using cross section data corrected for temperature (Doppler) effects suggest that temperature may have a relatively lesser influence on transmutation rates.
description: 9 pages, 10 figures
Interpretations of the Continental Reformation in Great Britain during the nineteenth century
Creators: name: Frappell, Leighton Oliver
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: The following inquiry seeks to identify and explore a number of more or less well defined traditions of Reformation interpretation, many of which had their rise in the seventeenth and eighteenth centuries and which were current in Great Britain during the nineteenth century. Thus it explores, for example, the liberal idea of the Reformation, the Protestant evangelical idea, the Roman Catholic idea, and so on. It is concerned also with showing how, behind these various interpretations, lies a remarkable common attitude to the very problem of interpretation-an attitude which may be described, following Butterfield,as the which approach to history; that is,considering the past from the standpoint of the present rather than in its own right. Also, the inquiry seeks to show something of the progress of thorough Reformation scholarship in Great Britain,especially in the last quarter of the century, and to that end examines the writings of a number of historians who were pioneers in Great Britain of a Reformation history which would eventually become emancipated from confessional bias; although these pioneers were themselves rarely free of a predetermined view of the Reformation, into which their critical findings were fitted, not always with complete success. The emphasis of the study is not so much upon the Reformation interpretations for their own sakes, but as the products of a variety of political and religious presuppositions as these sought to explain the meaning and significance of a key event in the making of modern times.
Scoping review of models explaining mental health impacts due to extreme weather events directly linked to climate change
Creators: name: Willis, Royce
name: Brymer, Eric
name: Rogers, Margaret
name: Sharma-Brymer, Vinathe
name: Bhullar, Navjot
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Public Health
subject: Social Work
subject: FOS: Sociology
subject: Mental and Social Health
subject: Counseling
subject: Medicine and Health Sciences
subject: Psychology
subject: FOS: Psychology
subject: Social and Behavioral Sciences

description: A scoping review will be undertaken to investigate existing models that aim to explain mental health impacts due to extreme weather events directly linked to climate change. To our knowledge, there is no review addressing this topic. The mental health impacts due to climate change is a growing research field. This review is aimed at consolidating the research of existing explanatory models.
Resonance Absorption of Terahertz Radiation in Nanoperforated Graphene
Creators: name: Enaldiev, V. V.
name: Volkov, V. A.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Recent measurements of the conductivity of nanoperforated graphene are interpreted in terms of edges states existing near the edge of each nanohole. The perimetric quantization of edge states should result in the formation of a quasi-equidistant ladder of quasistationary energy levels. Dirac fermions filling this ladder rotate about each nanohole in the direction determined by the valley index. It is shown that the irradiation of this system by circularly polarized terahertz radiation leads to a resonance in absorption in one of the valleys. The magnitude of absorption at the resonance frequency can be controlled by means of gate voltage.
title: ADCO, Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Cart. 32 (G 136), 745 folios, f. 0039
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 0039, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Neuvième cartulaire de Saint-Étienne de Dijon (1661 - 1684), Archives départementales de la Côte-d'Or, Cart. 32 (G 136), 745 folios, f. 0039, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Role of 1-D finite size Heisenberg chain in increasing metal to insulator transition temperature in hole rich VO2
Creators: name: Basu, Raktima
name: Sardar, Manas
name: Bera, Santanu
name: Magudapathy, P.
name: Dhara, Sandip
Publisher: name: arXiv
Year: 2017
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: VO2 samples are grown with different oxygen concentrations leading to different monoclinic, M1 and triclinic, T insulating phases which undergo a first order metal to insulator transition (MIT) followed by a structural phase transition (SPT) to rutile tetragonal phase. The metal insulator transition temperature (Tc) was found to be increased with increasing native defects. Vanadium vacancy (VV) is envisaged to create local strains in the lattice which prevents twisting of the V-V dimers promoting metastable monoclinic, M2 and T phases at intermediate temperatures. It is argued that MIT is driven by strong electronic correlation. The low temperature insulating phase can be considered as a collection of one-dimensional (1-D) half-filled band, which undergoes Mott transition to 1-D infinitely long Heisenberg spin 1/2 chains leading to structural distortion due to spin-phonon coupling. Presence of VV creates localized holes (d0) in the nearest neighbor, thereby fragmenting the spin 1/2 chains at nanoscale, which in turn increase the Tc value more than that of an infinitely long one. The Tc value scales inversely with the average size of fragmented Heisenberg spin 1/2 chains following a critical exponent of 2/3, which is exactly the same predicted theoretically for Heisenberg spin 1/2 chain at nanoscale undergoing SPT (spin-Peierls transition). Thus, the observation of MIT and SPT at the same time in VO2 can be explained from our phenomenological model of reduced 1-D Heisenberg spin 1/2 chains. The reported increase (decrease) in Tc value of VO2 by doping with metal having valency less (more) than four, can also be understood easily with our unified model, for the first time, considering finite size scaling of Heisenberg chains.
Additional file 2 of DNA and RNA-sequence based GWAS highlights membrane-transport genes as key modulators of milk lactose content
Creators: name: Lopdell, Thomas
name: Tiplady, Kathryn
name: Struchalin, Maksim
name: Johnson, Thomas
name: Keehan, Michael
name: Ric Sherlock
name: Couldrey, Christine
name: Davis, Stephen
name: Snell, Russell
name: Spelman, Richard
name: Littlejohn, Mathew
Publisher: name: figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: 60506 Virology
subject: Computational Biology

description: Figure S2. WGS resolution for 1Mbp windows centred on QTL peaks for lactose phenotypes. (PDF 1010 kb)
title: ADCO, Troisième cartulaire de Saint-Étienne de Dijon (XVIe), Cart. 23 (G 127), 310 folios, f. 00143
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2011
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Troisième cartulaire de Saint-Étienne de Dijon (XVIe), Archives départementales de la Côte-d'Or, Cart. 23 (G 127), 310 folios, f. 00143, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Troisième cartulaire de Saint-Étienne de Dijon (XVIe), Archives départementales de la Côte-d'Or, Cart. 23 (G 127), 310 folios, f. 00143, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Additional file 1: of Spread of the florfenicol resistance floR gene among clinical Klebsiella pneumoniae isolates in China
Creators: name: Lu, Junwan
name: Zhang, Jinfang
name: Xu, Lei
name: Liu, Yabo
name: Li, Pingping
name: Zhu, Tingyuan
name: Cheng, Cong
name: Lu, Shunfei
name: Xu, Teng
name: Yi, Huiguang
name: Li, Kewei
name: Zhou, Wu
name: Li, Peizhen
name: Ni, Liyan
name: Bao, Qiyu
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: Developmental Biology
subject: Plant Biology
subject: Virology

description: Table S1 Grouping of 105 floR gene containing sequences and their origins. (PDF 67 kb)
Additional file 1: Table S1. of Perceived Medical School stress of undergraduate medical students predicts academic performance: an observational study
Creators: name: Kötter, Thomas
name: Wagner, Josefin
name: Brüheim, Linda
name: Voltmer, Edgar
Publisher: name: figshare
Year: 2017
Subjects: subject: Space Science
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: PMSS items (english wording); Table S2. Longitudinal results from our sample. Description of data / legend: The (english language) wording of the PMSS items [8, 16] is presented in Table S1. Table S2 shows the mean scores for the single PMSS items, as well as the sum scores for T1 and T2. Results of the dependent t-tests for paired samples are also shown in Table S2. (DOCX 18 kb)
Optimal entry strategy of a remanufacturer and its impact on carbon reductions with online consumer reviews
Creators: name: Han, Xiaohua
name: Yan, Xin
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Computational Biology

description: This study attempts to examine the effects of online consumer reviews on a remanufacturer’s entry strategy and carbon reductions. We consider a manufacturer selling a new product over two periods in online retailing, and a remanufacturer determines whether to enter the market in the first or second period to sell a remanufactured product. We find that online consumer reviews have significant impacts. First, the remanufacturer does not always choose the first-period entry strategy. Second, the remanufacturer’s earlier entry is not always detrimental to the manufacturer, but can effectively reduce carbon emissions. Third, both firms’ pricing decisions, total payoffs and carbon emission reductions are closely related to the initial consumer base in the first period, and both firms do not always benefit from online consumer reviews. Finally, online consumer reviews are beneficial to the environment when there are less primary consumers, and vice versa.
Potential relationship of epistemic games to group dynamics and learning orientations towards physics problem solving
Creators: name: Mason, Andrew J.
name: Bertram, Charles A.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Physics Education (physics.ed-ph)
subject: FOS: Physical sciences

description: Current investigations into pedagogical goals of introductory algebra-based physics students at the University of Central Arkansas, by learning orientation towards an in-class metacognitive group problem solving task, seek to determine possible relationships with attitudinal shifts and course performance. Students thus far have been untreated with known group-based learning pedagogies, so as to establish trends of common group habits, and ultimately to properly inform implementation of group-based pedagogies in reaction to these trends. However, students' group dynamics and learning orientations prove difficult to map to group-based measurements; an estimate of group learning orientation and preferred working group dynamic is here explored as a potential means of interpreting students' use of problem solving strategies. A means of "sampling" audiovisual data in a live classroom of several simultaneous groups is also presented as a way to estimate the frequency of chosen strategies to this end.
description: 4 pages, 2 figures, 2 tables, conference proceedings
A Collapse of the Eastern Mediterranean? New results and theories on the interplay between climate and societies in Byzantium and the Near East, ca. 1000-1200 AD
Creators: name: Preiser-Kapeller, Johannes
Publisher: name: arXiv
Year: 2017
Subjects: subject: Physics and Society (physics.soc-ph)
subject: FOS: Physical sciences

description: This paper discusses a recently proposed scenario of a climate-induced Collapse of the Eastern Mediterranean in the 11th century AD. It demonstrates that such a scenario cannot be maintained when confronted with proxy data from various regions. On the other hand, data on the interplay between environment and economy in the Komnenian period (1081-1185) and evidence for a change of climatic conditions in the period of the Angeloi (1185-1204) is presented, arguing that climatic parameters should be taken into consideration when comparing socio-economic dynamics in the Eastern Mediterranean with those in Western Europe. The necessity of further research on the regional as well as over-regional level for many aspects of the interaction between human society and environment in the medieval Eastern Mediterranean is highlighted.
description: Peer-reviewed; with seven appendices, including three tables and 33 figures
Internet of Things based mechatronic system
Creators: name: Simpson, David
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: This thesis has the purpose of developing a new Internet of Things controlled mechatronic system. The ability to remotely control mechatronic systems opens up a world of possibilities for new devices, as well as upgrading existing technologies. Throughout this project, a new Internet of Things framework was created from scratch, including an Android application, cloud based web server and a mobile mechatronic system to execute user commands. All of these project components were newly developed and designed to provide a potential teaching platform for future students of wireless mechatronics. The Android application communicates user commands to the web server which acts as a 'fixed point' to which both the mechatronic system and the Android application can communicate. The web server saves any received command data into an SQL database for analysis, and then encrypts the data. The mechatronic system is a mobile robot designed from the ground up using CAD tools and then 3D printed to allow for future design changes. The robot polls the web server at a set interval to check for new commands. The overall Internet of Things framework developed during the project is functional, but requires further software development to make the system more robust and completely secure.
WHY DO WE FARM? A STATISTICAL ANALYSIS OF THE FORAGING-FARMING TRANSITION IN THE INTERIOR EASTERN WOODLANDS OF NORTH AMERICA
Creators: name: Torquato, Melissa G
Publisher: name: Purdue University Graduate School
Year: 2024
Subjects: classificationCode: 430102
subject: Archaeology of Asia, Africa and the Americas
classificationCode: 440199
subject: Anthropology not elsewhere classified

description: Early agriculture represents a critical change in human subsistence strategy in the Interior Eastern Woodlands of North America. Given that this change in diet is associated with an overall decline in nutrition and health, scholars have often wondered why such a transition would have occurred in the region. Since the foraging-farming transition is known to be a global phenomenon, numerous hypotheses have been proposed to explain this foraging-farming transition. These hypotheses include environmental hypotheses, sociocultural hypotheses, demographic hypotheses, risk-based hypotheses, co-evolutionary hypotheses, and aggrandizement hypotheses. Previous research in North America has focused on demographic hypotheses, risk-based hypotheses, and sociocultural hypotheses. One area that has not received attention in North America is the effect of climate change on the emergence of agriculture under the environmental hypotheses.Although scholars previously thought the climate did not change during the foraging-farming transition, more recent research has suggested otherwise. Thus, the goal of this dissertation is to explore how climate change influenced the foraging-farming transition in the Interior Eastern Woodlands of North America. I combine paleoenvironmental reconstructions, cultural resource management (CRM) data, and multivariate statistical methods to examine the effect of climate change on the foraging-farming transition. Using advanced statistical methods, I found that increases in mean annual temperature and mean annual precipitation are associated with the plant-dominated diets of the foraging-farming transition. Furthermore, these later occurring plant-dominated diets are associated with an increased prevalence of cultivars like sunflowers, maygrass, goosefoot, marshelder, and squash. Additionally, a comparison of the northern Interior Eastern Woodlands and the southern Interior Eastern Woodlands revealed different impacts of climate change on diet.This study provides a methodological advancement in the field of anthropology. Specifically, the application of advanced statistical methods to explore the effect of climate change on the foraging-transition is novel. Additionally, the compilation and use of a large dataset in analyses demonstrates the usefulness of CRM data when exploring regional trends.
A novel nanoparticle drug delivery system based on PEGylated hemoglobin for cancer therapy
Creators: name: Zhao, Yongmei
name: Chen, Gang
name: Meng, Zhengjie
name: Gong, Guangming
name: Zhao, Wei
name: Wang, Kaikai
name: Liu, Tianqing
Publisher: name: Taylor & Francis
Year: 2019
Subjects: Biophysics
Biochemistry
Space Science
Medicine
Pharmacology
Biotechnology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Developmental Biology
Cancer

description: Proteins such as albumin, gelatin, casein, transferrin, and collagen are widely used as drug delivery systems. However, only albumin-based paclitaxel (PTX) formulation Abraxane® (PTX-albumin NPs prepared by nab-technology) has been successfully developed for treating metastatic breast cancer clinically due to abundant materials, simple industrial scale-up process, and well tumor-targeting ability. Hemoglobin (Hb) is another protein used for drug delivery with similar advantages. In this study, we successfully synthesized PEG-Hb nanoparticles loading with PTX based on previously well-established acid-denatured method. PEG-Hb-PTX NPs showed enhanced cellular uptake and great cellular inhibition ability in vitro. Moreover, our animal study showed that PEGylated NPs greatly accumulated in tumor tissues and exhibited excellent anticancer activity in vivo. We found that PEG-Hb-PTX NPs possess a better in vivo antitumor effect than the commercially available Taxol® formulation. We believe that PEG-Hb has great potential as an efficient drug delivery system for further clinic study.
Shape-independent Hardness Estimation Using Deep Learning and a GelSight Tactile Sensor
Creators: name: Yuan, Wenzhen
name: Zhu, Chenzhuo
name: Owens, Andrew
name: Srinivasan, Mandayam A.
name: Adelson, Edward H.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: Hardness is among the most important attributes of an object that humans learn about through touch. However, approaches for robots to estimate hardness are limited, due to the lack of information provided by current tactile sensors. In this work, we address these limitations by introducing a novel method for hardness estimation, based on the GelSight tactile sensor, and the method does not require accurate control of contact conditions or the shape of objects. A GelSight has a soft contact interface, and provides high resolution tactile images of contact geometry, as well as contact force and slip conditions. In this paper, we try to use the sensor to measure hardness of objects with multiple shapes, under a loosely controlled contact condition. The contact is made manually or by a robot hand, while the force and trajectory are unknown and uneven. We analyze the data using a deep constitutional (and recurrent) neural network. Experiments show that the neural net model can estimate the hardness of objects with different shapes and hardness ranging from 8 to 87 in Shore 00 scale.
Additional file 1 of DNA and RNA-sequence based GWAS highlights membrane-transport genes as key modulators of milk lactose content
Creators: name: Lopdell, Thomas
name: Tiplady, Kathryn
name: Struchalin, Maksim
name: Johnson, Thomas
name: Keehan, Michael
name: Ric Sherlock
name: Couldrey, Christine
name: Davis, Stephen
name: Snell, Russell
name: Spelman, Richard
name: Littlejohn, Mathew
Publisher: name: figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Plant Biology

description: Figure S1. Stratification in the 30,000 discovery and validation animals, illustrated using PCA on the GRM matrix. Animals are coloured by the percentages of ancestry recorded in the LIC animal recording database. Breeds are Jersey and Holstein-Friesian. PCA was performed using GCTA [46]. (PDF 1770 kb)
Low temperature oxidation of coal
Creators: name: Day, Stuart J
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: The kinetics of oxidation of a high volatile bituminous coal have been studied at temperatures between 75 and 120 °C and particle sizes between 0.125 and 24 mm. The rate of oxidation was found to increase with increasing temperature yielding an activation energy of about 45 kJ/mol. At temperatures below about 75 °C the oxidation rate was essentially independent of the particle size but at higher temperatures, the rate tended to decrease with increasing particle size. For all of the temperatures examined, however, the rate remained independent of particle size if the particles were less than about 1 mm in diameter. This suggests that in those regimes where there is no particle size dependence, the overall rate of oxidation is under chemical control whereas in regions where the rate reduces with increasing particle diameter, diffusion becomes the rate limiting mechanism. -- Several oxidation rate models were tested against the experimental results. Of these, a modification of the shrinking core model in which each particle was assumed to be made up of many individual shrinking cores provided the best fit yielding excellent agreement with the measured rates. -- Moisture adsorption isotherms and the rate of moisture uptake by the coal were studied at temperatures between 10 and 60 °C and relative humidities ranging from about 10 to 100 percent. At all temperatures, moisture adsorption followed the Langmuir isotherm up to about 80 percent relative humidity but above this level the moisture content of the coal was substantially underestimated by the Langmuir model. An empirical model originally proposed by Henderson was found to provide a better fit over the full relative humidity range. The rate of moisture uptake increased with increasing relative humidity and temperature but decreased with increasing particle size. A rate model, similar in form to the shrinking core model, provided a very good fit to the experimental data and successfully predicted the effects of temperature, relative humidity and particle size on the rate of adsorption.
Supplementary images from The mechanobiology of actin cytoskeletal proteins during the cell–cell fusion
Creators: name: Cong, Jing
name: Fang, Bing
name: Wang, Qian
name: Su, Yan
name: Gu, Tianqi
name: Luo, Tianzhi
Publisher: name: The Royal Society
Year: 2019

description: Supplementary images for a better understanding of the main text
Towards low-dimensional hole systems in Be-doped GaAs nanowires
Creators: name: Ullah, A. R.
name: Gluschke, J. G.
name: Krogstrup, P.
name: Sørensen, C. B.
name: Nygård, J.
name: Micolich, A. P.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: GaAs was central to the development of quantum devices but is rarely used for nanowire-based quantum devices with InAs, InSb and SiGe instead taking the leading role. p-type GaAs nanowires offer a path to studying strongly-confined 0D and 1D hole systems with strong spin-orbit effects, motivating our development of nanowire transistors featuring Be-doped p-type GaAs nanowires, AuBe alloy contacts and patterned local gate electrodes towards making nanowire-based quantum hole devices. We report on nanowire transistors with traditional substrate back-gates and EBL-defined metal/oxide top-gates produced using GaAs nanowires with three different Be-doping densities and various AuBe contact processing recipes. We show that contact annealing only brings small improvements for the moderately-doped devices under conditions of lower anneal temperature and short anneal time. We only obtain good transistor performance for moderate doping, with conduction freezing out at low temperature for lowly-doped nanowires and inability to reach a clear off-state under gating for the highly-doped nanowires. Our best devices give on-state conductivity 95 nS, off-state conductivity 2 pS, on-off ratio ~$10^{4}$, and sub-threshold slope 50 mV/dec at T = 4 K. Lastly, we made a device featuring a moderately-doped nanowire with annealed contacts and multiple top-gates. Top-gate sweeps show a plateau in the sub-threshold region that is reproducible in separate cool-downs and indicative of possible conductance quantization highlighting the potential for future quantum device studies in this material system.
Planet-Induced Stellar Pulsations in HAT-P-2's Eccentric System
Creators: name: de Wit, J.
name: Lewis, N. K.
name: Knutson, H. A.
name: Fuller, J.
name: Antoci, V.
name: Fulton, B. J.
name: Laughlin, G.
name: Deming, D.
name: Shporer, A.
name: Batygin, K.
name: Cowan, N. B.
name: Agol, E.
name: Burrows, A. S.
name: Fortney, J. J.
name: Langton, J.
name: Showman, A. P.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Extrasolar planets on eccentric short-period orbits provide a laboratory in which to study radiative and tidal interactions between a planet and its host star under extreme forcing conditions. Studying such systems probes how the planet's atmosphere redistributes the time-varying heat flux from its host and how the host star responds to transient tidal distortion. Here, we report the insights into the planet-star interactions in HAT-P-2's eccentric planetary system gained from the analysis of 350 hr of 4.5 micron observations with the Spitzer Space Telescope. The observations show no sign of orbit-to-orbit variability nor of orbital evolution of the eccentric planetary companion, HAT-P-2 b. The extensive coverage allows us to better differentiate instrumental systematics from the transient heating of HAT-P-2 b's 4.5 micron photosphere and yields the detection of stellar pulsations with an amplitude of approximately 40 ppm. These pulsation modes correspond to exact harmonics of the planet's orbital frequency, indicative of a tidal origin. Transient tidal effects can excite pulsation modes in the envelope of a star, but, to date, such pulsations had only been detected in highly eccentric stellar binaries. Current stellar models are unable to reproduce HAT-P-2's pulsations, suggesting that our understanding of the interactions at play in this system is incomplete.
description: Published in ApJL on 14 Feb 2017
Additional file 1 of Effectiveness of janus kinase inhibitors in relapsing giant cell arteritis in real-world clinical practice and review of the literature
Creators: name: Loricera, Javier
name: Tofade, Toluwalase
name: Prieto-Peña, Diana
name: Romero-Yuste, Susana
name: de Miguel, Eugenio
name: Riveros-Frutos, Anne
name: Ferraz-Amaro, Iván
name: Labrador, Eztizen
name: Maiz, Olga
name: Becerra, Elena
name: Narváez, Javier
name: Galíndez-Agirregoikoa, Eva
name: González-Fernández, Ismael
name: Urruticoechea-Arana, Ana
name: Ramos-Calvo, Ángel
name: López-Gutiérrez, Fernando
name: Castañeda, Santos
name: Unizony, Sebastian
name: Blanco, Ricardo
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Mental Health
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Supplementary Material 1