title: ÐÐ»Ð¸ÑÐ½Ð¸Ðµ Ñ Ð¸Ð¼Ð¸ÑÐµÑÐºÐ¸ ÑÐ¾Ð·Ð´Ð°Ð½Ð½Ð¾Ð³Ð¾ Ð°Ð½Ð°Ð»Ð¾Ð³Ð° ÐºÐ¸ÑÑÐ¿ÐµÐ¿ÑÐ¸Ð½Ð° Ð½Ð° ÑÑÐ¾Ð²ÐµÐ½Ñ Ð¿Ð¾Ð»Ð¾Ð²ÑÑ Ð³Ð¾ÑÐ¼Ð¾Ð½Ð¾Ð² Ñ ÑÑÐ± Danio rerio
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: The effect of a chemically created analogue of kisspeptin on the level of reproductive hormones in fish Danio rerio
Creators: name: ÐÐ¾ÑÑÐ¸Ð½Ð°, ÐÐ°ÑÐ¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: ÐºÐ¸ÑÑÐ¿ÐµÐ¿ÑÐ¸Ð½
ÑÑÐµÑÐ¾Ð¸Ð´Ð½ÑÐµ Ð³Ð¾ÑÐ¼Ð¾Ð½Ñ
Danio rerio
ÑÐµÐ¿ÑÐ¾Ð´ÑÐºÑÐ¸Ñ
ÑÐ¾Ð»Ð»Ð¸ÐºÑÐ»Ð¾ÑÑÐ¸Ð¼ÑÐ»Ð¸ÑÑÑÑÐ¸Ð¹ Ð³Ð¾ÑÐ¼Ð¾Ð½
ÑÑÑÑÐ°Ð´Ð¸Ð¾Ð»
Ð¿ÑÐ¾Ð³ÐµÑÑÐµÑÐ¾Ð½
ÑÐµÑÑÐ¾ÑÑÐµÑÐ¾Ð½
kisspeptin
steroid hormones
reproduction
follicle stimulating hormone
estradiol
progesterone
testosterone

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description: This work is an experimental study of the effect of a synthetic analogue of kisspeptin on the level of FSH and sex steroid hormones in Danio rerio. The purpose of this study was to study the effect of a synthetic kisspeptin analogue on the level of reproductive hormones in Danio rerio. The synthetic peptide was administered intracerebrally to Danio rerio females in dosages of 1 and 4 micrograms and the material was taken after 1 hour or 4 hours. The fish were anesthetized and gonads were isolated and then examined for the quantitative content of sex steroids and FSH using solid-phase enzyme immunoassay. The commercial drug buserelin was used as a comparison drug. The administration of kisspeptin led to a decrease in testosterone levels, as well as an increase in progesterone levels in the gonads. The estradiol level remained without statistically significant changes. The level of gonadotropin FSH increased under the action of kisspeptin. The results obtained indicate the involvement of the kisspeptin signaling system in the regulation of FSH and sex steroids in Danio rerio. The most likely mechanism seems to be the regulation of sex steroids mediated by gonadotropin, in this case FSH. Danio rerio should be considered a promising model organism for experimental pharmacological studies and the study of reproductive function.