cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Correlative Confocal and 3D Electron Microscopy of a Specific Sensory Cell
Creators: name: Bohórquez, Diego
name: Liddle, Rodger A.
name: Haque, Fariha
name: Medicetty, Satish
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Delineation of a cell’s ultrastructure is important for understanding its function. This can be a daunting project for rare cell types diffused throughout tissues made of diverse cell types, such as enteroendocrine cells of the intestinal epithelium. These gastrointestinal sensors of food and bacteria have been difficult to study because they are dispersed among other epithelial cells at a ratio of 1:1,000. Recently, transgenic reporter mice have been generated to identify enteroendocrine cells by means of fluorescence. One of those is the peptide YY-GFP mouse. Using this mouse, we developed a method to correlate confocal and serial block-face scanning electron microscopy. We named the method cocem3D and applied it to identify a specific enteroendocrine cell in tissue and unveil the cell’s ultrastructure in 3D. The resolution of cocem3D is sufficient to identify organelles as small as secretory vesicles and to distinguish cell membranes for volume rendering. Cocem3D can be easily adapted to study the 3D ultrastructure of other specific cell types in their native tissue.
Electroretinogram Analysis of the Visual Response in Zebrafish Larvae
Creators: name: Rebrik, Tatiana I.
name: Chrispell, Jared D.
name: Weiss, Ellen R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The electroretinogram (ERG) is a noninvasive electrophysiological method for determining retinal function. Through the placement of an electrode on the surface of the cornea, electrical activity generated in response to light can be measured and used to assess the activity of retinal cells in vivo. This manuscript describes the use of the ERG to measure visual function in zebrafish. Zebrafish have long been utilized as a model for vertebrate development due to the ease of gene suppression by morpholino oligonucleotides and pharmacological manipulation. At 5-10 dpf, only cones are functional in the larval retina. Therefore, the zebrafish, unlike other animals, is a powerful model system for the study of cone visual function in vivo. This protocol uses standard anesthesia, micromanipulation and stereomicroscopy protocols that are common in laboratories that perform zebrafish research. The outlined methods make use of standard electrophysiology equipment and a low light camera to guide the placement of the recording microelectrode onto the larval cornea. Finally, we demonstrate how a commercially available ERG stimulator/recorder originally designed for use with mice can easily be adapted for use with zebrafish. ERG of larval zebrafish provides an excellent method of assaying cone visual function in animals that have been modified by morpholino oligonucleotide injection as well as newer genome engineering techniques such as Zinc Finger Nucleases (ZFNs), Transcription Activator-Like Effector Nucleases (TALENs), and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9, all of which have greatly increased the efficiency and efficacy of gene targeting in zebrafish. In addition, we take advantage of the ability of pharmacological agents to penetrate zebrafish larvae to evaluate the molecular components that contribute to the photoresponse. This protocol outlines a setup that can be modified and used by researchers with various experimental goals.
Cyber-Physical-Internet-Driven Logistics Infrastructure Integration in the Greater Bay Area
Creators: name: Wu, Hang
name: Li, Ming
name: Huang, George Q.
Publisher: name: Georgia Institute of Technology
Year: 2023
Subjects: Cyber-physical internet
Infrastructure integration
CPI routing mechanism

description: Presented at the 9th International Physical Internet Conference (IPIC 2023) 13-15 June 2023, Athens, Greece
description: Objectives: 1) To establish a logistics infrastructure integration network based on the existing logistics infrastructure in the GBA; 2) To migrate the general features of the computer network fusion to CPI and establish an infrastructure integration network with good real-time performance; 3) To design an innovative path evaluation mechanism and specific routing mechanisms for CPI with motivation of data package routing in computer networks.
Improved Generation of Induced Cardiomyocytes Using a Polycistronic Construct Expressing Optimal Ratio of Gata4, Mef2c and Tbx5
Creators: name: Liu, Ziqing
name: Zhou, Yang
name: Liu, Jiandong
name: Yin, Chaoying
name: Wang, Li
name: Qian, Li
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Direct conversion of cardiac fibroblasts (CFs) into induced cardiomyocytes (iCMs) holds great potential for regenerative medicine by offering alternative strategies for treatment of heart disease. This conversion has been achieved by forced expression of defined factors such as Gata4 (G), Mef2c (M) and Tbx5 (T). Traditionally, iCMs are generated by a cocktail of viruses expressing these individual factors. However, reprogramming efficiency is relatively low and most of the in vitro G,M,T-transduced fibroblasts do not become fully reprogrammed, making it difficult to study the reprogramming mechanisms. We recently have shown that the stoichiometry of G,M,T is crucial for efficient iCM reprogramming. An optimal stoichiometry of G,M,T with relative high level of M and low levels of G and T achieved by using our polycistronic MGT vector (hereafter referred to as MGT) significantly increased reprogramming efficiency and improved iCM quality in vitro. Here we provide a detailed description of the methodology used to generate iCMs with MGT construct from cardiac fibroblasts. Isolation of cardiac fibroblasts, generation of virus for reprogramming and evaluation of the reprogramming process are also included to provide a platform for efficient and reproducible generation of iCMs.
Measurement of electrons from heavy-flavor decays from $p$+$p$, $d$+Au, and Cu+Cu collisions in the PHENIX experiment
Creators: name: Lim, Sanghoon
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Charm and bottom quarks are formed predominantly by gluon fusion in the initial hard scatterings at RHIC, making them good probes of the full medium evolution. Previous measurements at RHIC have shown large suppression and azimuthal anisotropy of open heavy-flavor hadrons in Au+Au collisions at $\sqrt{s_{NN}}=200~{\rm GeV}$. Explaining the simultaneously large suppression and flow of heavy quarks has been challenging. To further understand the heavy-flavor transport in the hot and dense medium, it is imperative to also measure cold nuclear matter effects which affect the initial distribution of heavy quarks as well as the system size dependence of the final state suppression. In this talk, new measurements by the PHENIX collaboration of electrons from heavy-flavor decays in $p$+$p$, $d$+Au, and Cu+Cu collisions at $\sqrt{s_{NN}}=200~{\rm GeV}$ are presented. In particular, a surprising enhancement of intermediate transverse momentum heavy-flavor decay leptons in $d$+Au at mid and backward rapidity are also seen in mid-central Cu+Cu collisions. This enhancement is much larger than the expectation from anti-shadowing of the parton distributions and is theoretically unexplained.
description: 4 pages, 4 figures, talk in Quark Matter 2014, 19-24 May 2014, Darmstadt, Germany
Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
Creators: name: Gipson, Gregory R.
name: Sheikh, Shehzad Z.
name: Steinbach, Erin C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: There are many different animal models available for studying the pathogenesis of human inflammatory bowel diseases (IBD), each with its own advantages and disadvantages. We describe here an experimental colitis model that is initiated by adoptive transfer of syngeneic splenic CD4+CD45RBhigh T cells into T and B cell deficient recipient mice. The CD4+CD45RBhigh T cell population that largely consists of naïve effector cells is capable of inducing chronic intestinal inflammation, closely resembling key aspects of human IBD. This method can be manipulated to study aspects of disease onset and progression. Additionally it can be used to study the function of innate, adaptive, and regulatory immune cell populations, and the role of environmental exposures, i.e., the microbiota, in intestinal inflammation. In this article we illustrate the methodology for inducing colitis with a step-by-step protocol. This includes a video demonstration of key technical aspects required to successfully develop this murine model of experimental colitis for research purposes.
Online Detection of Supply Chain Network Disruptions Using Sequential Change-Point Detection for Hawkes Processes
Creators: name: Yamin, Khurram
name: Wang, Haoyun
name: Montreuil, Benoit
name: Xie, Yao
Publisher: name: Georgia Institute of Technology
Year: 2023
Subjects: Change-point detection
Time-series analysis, supply-chain

description: Presented at the 9th International Physical Internet Conference (IPIC 2023) 13-15 June 2023, Athens, Greece
description: In this Paper, we attempt to detect an inflection or change-point resulting from the Covid-19 pandemic on supply chain data received from a large furniture company. To accomplish this, we utilize a modified CUSUM (Cumulative Sum) procedure on the company's spatial-temporal order data as well as a GLR (Generalized Likelihood Ratio) based method. We model the order data using the Hawkes Process Network, a multi-dimensional self and mutually exciting point process, by discretizing the spatial data and treating each order as an event that has a corresponding node and time. We apply the methodologies on the company's most ordered item on a national scale and perform a deep dive into a single state. Because the item was ordered infrequently in the state compared to the nation, this approach allows us to show efficacy upon different degrees of data sparsity. Furthermore, it showcases use potential across differing levels of spatial detail.
On-the-fly ab initio semiclassical dynamics: Identifying degrees of freedom essential for emission spectra of oligothiophenes
Creators: name: Wehrle, Marius
name: Sulc, Miroslav
name: Vanicek, Jiri
Publisher: name: arXiv
Year: 2014
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: Vibrationally resolved spectra provide a stringent test of the accuracy of theoretical calculations. We combine the thawed Gaussian approximation (TGA) with an on-the-fly ab initio (OTF-AI) scheme to calculate the vibrationally resolved emission spectra of oligothiophenes with up to five rings. The efficiency of the OTF-AI-TGA permits treating all vibrational degrees of freedom on an equal footing even in pentathiophene with 105 vibrational degrees of freedom, thus obviating the need for the global harmonic approximation, popular for large systems. Besides reproducing almost perfectly the experimental emission spectra, in order to provide a deeper insight into the associated physical and chemical processes, we also develop a novel systematic approach to assess the importance and coupling between individual vibrational degrees of freedom during the dynamics. This allows us to explain how the vibrational line shapes of the oligothiophenes change with increasing number of rings. Furthermore, we observe the dynamical interplay between the quinoid and aromatic characters of individual rings in the oligothiophene chain during the dynamics and confirm that the quinoid character prevails in the center of the chain.
Additional file 3 of Evaluating methodological approaches to assess the severity of infection with SARS-CoV-2 variants: scoping review and applications on Belgian COVID-19 data
Creators: name: Meurisse, Marjan
name: Van Oyen, Herman
name: Blot, Koen
name: Catteau, Lucy
name: Serrien, Ben
name: Klamer, Sofieke
name: Cauët, Emilie
name: Robert, Annie
name: Van Goethem, Nina
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 3: Figure S2. The number of Belgian hospitalized COVID-19 patients registered in the Clinical Hospital Surveillance (CHS) and admitted between the 1st of March 2021 and the 28th of March 2022 by the availability of SARS-CoV-2 variant information (variant information confirmed by Whole Genome Sequencing (WGS) available versus no confirmed variant information available) (left y-axis) and the coverage of Belgian hospitalized COVID-19 patients with confirmed variant information, i.e. percentage of patients with available confirmed (by WGS) viral information, among the of Belgian hospitalized COVID-19 patients admitted between the 1st of March 2021 and the 28th of March 2022 (right y-axis).
InnoPortAR: Innovative applications for augmented reality in inland ports and seaports
Creators: name: Schulte-Hobein, Nina
name: Lück, Ingo
name: Stewing, Franz-Josef
name: Klukas, Achim
name: Lorenz, Maximiliane
Publisher: name: Georgia Institute of Technology
Year: 2023
Subjects: Augmented reality
Assisted reality
Mixed reality
Inland ports
Seaports
HoloLens 2

description: Presented at the 9th International Physical Internet Conference (IPIC 2023) 13-15 June 2023, Athens, Greece
description: The funded R&D project InnoPortAR (IHATEC 19H18008) ran from 2018 until the end of 2021 and focused on the improvement and digitization of workflows in inland ports through the implementation of Augmented Reality (AR) technology. Augmented Reality (AR) solutions enhance the user’s perception of the real world by overlaying digital information, such as images, videos, or 3D models, onto the physical environment with the help of a device. The central challenge of InnoPortAR was to develop and test AR solutions for the port environment and give a first indicator on possible use cases and scenarios. Therefore, four use cases were selected to be implemented across the port and terminal environment: maintenance of port equipment, ship loading and unloading, container stuffing, and entrance inspection of trucks and containers at the container terminal. In all use cases, the AR solutions led to shortened process times, error prevention and better documentation. The AR apps were also successfully used to guide and train new dockers.
Instillation and Fixation Methods Useful in Mouse Lung Cancer Research
Creators: name: Limjunyawong, Nathachit
name: Mock, Jason
name: Mitzner, Wayne
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The ability to instill live agents, cells, or chemicals directly into the lung without injuring or killing the mice is an important tool in lung cancer research. Although there are a number of methods that have been published showing how to intubate mice for pulmonary function measurements, none are without potential problems for rapid tracheal instillation in large cohorts of mice. In the present paper, a simple and quick method is described that enables an investigator to carry out such instillations in an efficient manner. The method does not require any special tools or lighting and can be learned with very little practice. It involves anesthetizing a mouse, making a small incision in the neck to visualize the trachea, and then inserting an intravenous catheter directly. The small incision is quickly closed with tissue adhesive, and the mice are allowed to recover. A skilled student or technician can do instillations at an average rate of 2 min/mouse. Once the cancer is established, there is frequently a need for quantitative histologic analysis of the lungs. Traditionally pathologists usually do not bother to standardize lung inflation during fixation, and analyses are often based on a scoring system that can be quite subjective. While this may sometime be sufficiently adequate for gross estimates of the size of a lung tumor, any proper stereological quantification of lung structure or cells requires a reproducible fixation procedure and subsequent lung volume measurement. Here we describe simple reliable procedures for both fixing the lungs under pressure and then accurately measuring the fixed lung volume. The only requirement is a laboratory balance that is accurate over a range of 1 mg–300 g. The procedures presented here thus could greatly improve the ability to create, treat, and analyze lung cancers in mice.
Blockchain-based electronic exchange of freight transport information (eFTI)
Creators: name: Rachaniotis, Nikolaos
name: Dasaklis, Thomas
name: Kopanaki, Evangelia
Publisher: name: Georgia Institute of Technology
Year: 2023
Subjects: Efti
Freight transport
Blockchain
Standardization

description: Presented at the 9th International Physical Internet Conference (IPIC 2023) 13-15 June 2023, Athens, Greece
description: Blockchain technology has the potential to revolutionize the way eFTI systems work, by offering reliability, transparency, traceability and data security. However, alternative technical solutions are still considered in the European Union, while legal and business are not yet resolved.
Lead-time -based Routing of Freight in PI Networks
Creators: name: Shahedi, Alireza
name: Sacco, Nicola
name: Saeednia, Mahnam
Publisher: name: Georgia Institute of Technology
Year: 2023
Subjects: Freight distribution
Decentralized systems
Multi-modal transport

description: Presented at the 9th International Physical Internet Conference (IPIC 2023) 13-15 June 2023, Athens, Greece
description: This study proposes a PI-based planning model for synchromodal operation of a transport network considering the parallel operation of intermodal and truck-only routes. The proposed multi-objective model seeks to satisfy the delivery time of goods while minimizing the number of trucks. The results obtained from the implementation and analysis of the model show the interplay between the importance of delivery time versus the environmental impact of transporting goods. However, it is possible to find a spot where these two objectives meet. A major impacting factor is the efficiency of the PI-hub in handling goods. Future work includes enhancing the model for consideration of constraints related to a more detailed load planning to consider the dimensions of modular containers and modeling the internal PI-hub operations and mirroring its impact on network operations.
Additional file 4 of Evaluating methodological approaches to assess the severity of infection with SARS-CoV-2 variants: scoping review and applications on Belgian COVID-19 data
Creators: name: Meurisse, Marjan
name: Van Oyen, Herman
name: Blot, Koen
name: Catteau, Lucy
name: Serrien, Ben
name: Klamer, Sofieke
name: Cauët, Emilie
name: Robert, Annie
name: Van Goethem, Nina
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 4: Figure S3. Vaccination status of Belgian hospitalized COVID-19 patients registered in the Clinical Hospital Survey (CHS). (Left) Number of Belgian hospitalized COVID-19 patients with a certain vaccination status over time, 7-day rolling average. (Right) Percentage of Belgian hospitalized COVID-19 patients with a certain vaccination status over time, 7-day rolling average. Periods of dominance of SARS-CoV-2 variants (more than 50% presence in baseline surveillance) are indicated as areas on the plot. Not vaccinated = no dose of a vaccine. Partially vaccinated = one dose of the BNT162b2, mRNA-1273 or NVX-CoV2373 vaccine. Fully vaccinated = one dose of the Ad26.COV2.S vaccine, two doses of the BNT162b2, mRNA-1273 or NVX-CoV2373 vaccine, or a mixture of two doses of the latter three vaccines (= primary vaccination schedule). Fully vaccinated + booster = primary vaccination schedule plus an additional dose of the BNT162b2 or mRNA-1273 vaccine.
Adaptive Multi-resolution 3D Hartree-Fock-Bogoliubov Solver for Nuclear Structure
Creators: name: Pei, Junchen
name: Fann, George
name: Harrison, Robert
name: Nazarewicz, Witold
name: Shi, Yue
name: Thornton, Scott
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Complex many-body systems, such as triaxial and reflection-asymmetric nuclei, weakly-bound halo states, cluster configurations, nuclear fragments produced in heavy-ion fusion reactions, cold Fermi gases, and pasta phases in neutron star crust, they are all characterized by large sizes and complex topologies, in which many geometrical symmetries characteristic of ground-state configurations are broken. A tool of choice to study such complex forms of matter is an adaptive multi-resolution wavelet analysis. This method has generated much excitement since it provides a common framework linking many diversified methodologies across different fields, including signal processing, data compression, harmonic analysis and operator theory, fractals, and quantum field theory. To describe complex superfluid many-fermion systems, we introduce an adaptive pseudo-spectral method for solving self-consistent equations of nuclear density functional theory in three dimensions, without symmetry restrictions. The new adaptive multi-resolution Hartree-Fock-Bogoliubov (HFB) solver {\madnesshfb} is benchmarked against a two-dimensional coordinate-space solver {\hfbax} based on B-spline technique and three-dimensional solver {\hfodd} based on the harmonic oscillator basis expansion. Several examples are considered, including self-consistent HFB problem for spin-polarized trapped cold fermions and Skyrme-Hartree-Fock (+BCS) problem for triaxial deformed nuclei. The new {\madnesshfb} framework has many attractive features when applied to nuclear and atomic problems involving many-particle superfluid systems. Of particular interest are weakly-bound nuclear configurations close to particle drip lines, strongly elongated and dinuclear configurations such as those present in fission and heavy ion fusion, and exotic pasta phases that appear in the neutron star crust.
description: 9 pages, 5 figures, submitted to PRC
Leg fracture associated with synostosis of interosseous membrane during running in a soccer player
Creators: name: Oliva, Francesco
name: Buharaja, Rodrigo
name: Iundusi, Riccardo
name: Tarantino, Umberto
Publisher: name: Universita' degli Studi di Salerno
Year: 2017
Subjects: Interosseous membrane
Leg fracture
Synostosis

description: ntroduction - Leg fractures may occur frequently in sport injuries but it is very rare to find this kind of injury associated with interosseous membrane synostosis. This case report describes a unique case of 42 B1.2 fracture of the leg associated with an interosseous membrane synostosis and literature review on Pubmed, Google scholar and Medscape. Case Presentation - A 26 year old male amateur soccer player came to our attention at the emergency room after a fall while he was running without any direct trauma following a referred ankle sprain. X-ray and CT scan of the left leg showed a comminuted displaced fracture of the lower middle third of tibial and peroneus diaphysis, and moreover, a fracture of peroneal malleolus associated with a bone bridge between the tibia and fibula. The patient was treated with a surgical osteosynthesis the day after trauma. Conclusion - We think that the interosseous membrane plays an important role in biomechanics of the leg even during running. To our knowledge, this is the first case reported which show the fractures of the tibia and fibula associated with an ipsilateral synostosis of the interosseous membrane. Class of evidence: Level V.
Isolation and Cryopreservation of Neonatal Rat Cardiomyocytes
Creators: name: Vandergriff, Adam C.
name: Cheng, Ke
name: Hensley, Michael Taylor
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Cell culture has become increasingly important in cardiac research, but due to the limited proliferation of cardiomyocytes, culturing cardiomyocytes is difficult and time consuming. The most commonly used cells are neonatal rat cardiomyocytes (NRCMs), which require isolation every time cells are needed. The birth of the rats can be unpredictable. Cryopreservation is proposed to allow for cells to be stored until needed, yet freezing/thawing methods for primary cardiomyocytes are challenging due to the sensitivity of the cells. Using the proper cryoprotectant, dimethyl sulfoxide (DMSO), cryopreservation was achieved. By slowly extracting the DMSO while thawing the cells, cultures were obtained with viable NRCMs. NRCM phenotype was verified using immunocytochemistry staining for α-sarcomeric actinin. In addition, cells also showed spontaneous contraction after several days in culture. Cell viability after thawing was acceptable at 40–60%. In spite of this, the methods outlined allow one to easily cryopreserve and thaw NRCMs. This gives researchers a greater amount of flexibility in planning experiments as well as reducing the use of animals.
Isolation and Transplantation of Different Aged Murine Thymic Grafts.
Creators: name: Manzoor, Fatima
name: Tisch, Roland
name: Morillon, Y. Maurice
name: Wang, Bo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The mechanisms that regulate the efficacy of thymic selection remain ill-defined. The method presented here allows in vivo analyses of the development and selection of T cells specific for self and foreign antigens. The approach entails implantation of thymic grafts derived from various aged mice into immunodeficient scid recipients. Over a relatively short period of time the recipients are fully reconstituted with T cells derived from the implanted thymus graft. Only thymocytes seeding the thymus at the time of isolation undergo selection and develop into mature T cells. As such, changes in the nature and specificity of the engrafted T cells as a function of age-dependent thymic events can be assessed. Although technical expertise is required for successful thymic transplantation, this method provides a unique strategy to study in vivo a wide range of pathologies that are due to or a result of aberrant thymic function and/or homeostasis.
Policy Approaches for Placing Parcel Lockers in Public Space
Creators: name: Dobber, Ruurd
name: Buijs, Paul
Publisher: name: Georgia Institute of Technology
Year: 2023
Subjects: Parcel lockers
Public policy
Last-mile logistics

description: Presented at the 9th International Physical Internet Conference (IPIC 2023) 13-15 June 2023, Athens, Greece
description: This Paper explores policy approaches for parcel lockers in public space. While lastmile delivery service providers primarily focus on the economic and customer service benefits of parcel lockers, securing approval from local governments to place lockers in public spaces requires justification of their public value. Our study identifies six factors that decisionmakers can consider when evaluating requests for parcel locker placement: carbon emissions, nuisances of the delivery vehicle, nuisances at a locker location, customer preferences, innovation, and the pull effect of parcel lockers. Through a series of semi-structured interviews and a workshop with public decisionmakers in cities across the Netherlands and Europe, we find that delivery vehicle nuisances and potential new nuisances at the locker location are important factors for decisionmakers at local government. Our study reveals two distinct approaches taken by local governments when facing requests for parcel locker placement in public spaces: reactive and proactive. Overall, this study contributes to the understanding of the policy perspective on parcel lockers in public spaces and provides insights for sustainable urban logistics planning.
Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
Creators: name: Weber, Mariko
name: Bizzell, Joshua
name: Gu, Hongbin
name: Hart, Sarah J.
name: Shaffer, Joseph J.
name: Belger, Aysenil
name: Perkins, Diana O.
name: McMahon, Mary A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Adolescence is a critical developmental period where the early symptoms of schizophrenia frequently emerge. First-degree relatives of people with schizophrenia who are at familial high risk (FHR) may show similar cognitive and emotional changes. However, the neurological changes underlying the emergence of these symptoms remain unclear. This study sought to identify differences in frontal, striatal, and limbic regions in children and adolescents with FHR using functional magnetic resonance imaging. Groups of 21 children and adolescents at FHR and 21 healthy controls completed an emotional oddball task that relied on selective attention and the suppression of task-irrelevant emotional information. The standard oddball task was modified to include aversive and neutral distractors in order to examine potential group differences in both emotional and executive processing. This task was designed specifically to allow for children and adolescents to complete by keeping the difficulty and emotional image content age-appropriate. Furthermore, we demonstrate a technique for suitable fMRI registration for children and adolescent participants. This paradigm may also be applied in future studies to measure changes in neural activity in other populations with hypothesized developmental changes in executive and emotional processing.
Modulation of trion and exciton formation in monolayer WS2 by dielectric and substrate engineering
Creators: name: Chowdhury, Tamaghna
name: Paul, Diptabrata
name: Nechiyil, Divya
name: A, Gokul M.
name: Watanabe, Kenji
name: Taniguchi, Takashi
name: Kumar, G. V. Pavan
name: Rahman, Atikur
Publisher: name: arXiv
Year: 2022
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: Photoluminescence (PL) of transition metal dichalcogenide (TMD) monolayers is strongly influenced by the dielectric environment. The defect states present in the substrate induces uncontrollable doping in the TMD monolayer and thereby modifies the PL spectra. There have been enormous efforts to tune and overcome the effect of inevitable subtract defects in PL spectra, but a proper understanding and a convenient way are still lacking. Here, we systematically studied the effect of surface defects by gradually increasing the separation between WS2 monolayer and substrate. Hence, we could precisely modulate the exciton and trion contribution in the PL spectra of WS2. The excitation power dependant measurements on dielectric engineered and patterned substrates helped us to shed light on the mechanism of PL modulation in monolayer WS2. We have also studied the influence of the nature of the charge carried by substrate defects on the PL spectra. These results open a new pathway to modulate and obtain the desired PL spectra of TMDs by engineering the substrates. Our findings will be useful for fabricating excitonic interconnects, valleytronic, and single-photon devices.
description: 16 pages, 5 figures
Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting
Creators: name: Meier, Helen
name: Wildman, Derek E.
name: Galea, Sandro
name: Soliven, Richelo
name: Coulborn, Rebecca M.
name: Weckle, Amy
name: Uddin, Monica
name: Aiello, Allison E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Collection and processing of whole blood samples in a non-clinical setting offers a unique opportunity to evaluate community-dwelling individuals both with and without preexisting conditions. Rapid processing of these samples is essential to avoid degradation of key cellular components. Included here are methods for simultaneous peripheral blood mononuclear cell (PBMC), DNA, RNA and serum isolation from a single blood draw performed in the homes of consenting participants across a metropolitan area, with processing initiated within 2 hr of collection. We have used these techniques to process over 1,600 blood specimens yielding consistent, high quality material, which has subsequently been used in successful DNA methylation, genotyping, gene expression and flow cytometry analyses. Some of the methods employed are standard; however, when combined in the described manner, they enable efficient processing of samples from participants of population- and/or community-based studies who would not normally be evaluated in a clinical setting. Therefore, this protocol has the potential to obtain samples (and subsequently data) that are more representative of the general population.
5G-enabled innovation in ports’ logistics: expectations from the 5G-LOGINNOV Project and relevance for the Physical Internet
Creators: name: Di Gregorio, Piergiuseppe
name: Apruzzese, Michela
Publisher: name: Georgia Institute of Technology
Year: 2023
Subjects: 5G
Logistics innovation
Stakeholders' expectations

description: Presented at the 9th International Physical Internet Conference (IPIC 2023) 13-15 June 2023, Athens, Greece
description: The EU funded 5G-LOGINNOV Project will support the generation of new 5Genabled technologies for logistics operations in three Living Labs (LLs): Athens, Hamburg, and Koper. Athens mainly deals with technologies for real-time tracking and enhanced visibility of 5G yard-trucks for service optimization, job allocation and predictive maintenance; Hamburg addresses the usage of 5G to improve port operations, specifically for connecting the Hinterland to the port’s facilities; Koper focuses on 5G enabled technologies to improve the automation of logistics processes in ports and to support mission critical services in the port area. Therefore, the Project will ensure relevant advancements for Physical Internet, pushing for supply chain synchronization and “5Gintelligent” approaches for the management, routing, and optimization of operations in ports areas. This study presented in the Paper aims to present the methodology to assess stakeholders’ expectations on the potential benefits of 5G-enabled technologies on business models and operation. While preliminary results of the assessment have been presented, the analysis will continue until the end of the demonstration period by assessing if stakeholders’ expectations have been met.
The rich complexity of 21-cm fluctuations produced by the first stars
Creators: name: Fialkov, Anastasia
name: Barkana, Rennan
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We explore the complete history of the 21-cm signal in the redshift range z = 7-40. This redshift range includes various epochs of cosmic evolution related to primordial star formation, and should be accessible to existing or planned low-frequency radio telescopes. We use semi-numerical computational methods to explore the fluctuation signal over wavenumbers between 0.03 and 1 Mpc$^{-1}$, accounting for the inhomogeneous backgrounds of Ly-$α$, X-ray, Lyman-Werner and ionizing radiation. We focus on the recently noted expectation of heating dominated by a hard X-ray spectrum from high-mass X-ray binaries. We study the resulting delayed cosmic heating and suppression of gas temperature fluctuations, allowing for large variations in the minimum halo mass that contributes to star formation. We show that the wavenumbers at which the heating peak is detected in observations should tell us about the characteristic mean free path and spectrum of the emitted photons, thus giving key clues as to the character of the sources that heated the primordial Universe. We also consider the line-of-sight anisotropy, which allows additional information to be extracted from the 21-cm signal. For example, the heating transition at which the cosmic gas is heated to the temperature of the cosmic microwave background should be clearly marked by an especially isotropic power spectrum. More generally, an additional cross-power component $P_X$ directly probes which sources dominate 21-cm fluctuations. In particular, during cosmic reionization (and after the just-mentioned heating transition), $P_X$ is negative on scales dominated by ionization fluctuations and positive on those dominated by temperature fluctuations.
description: Accepted for publication in MNRAS, 13 pages, 7 figures, 2 tables
Surgical Models of Gastroesophageal Reflux with Mice
Creators: name: He, Jinxi
name: Chen, Xiaoxin
name: Fang, Yu
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Multiple surgical procedures have been reported to induce gastroesophageal reflux in animals. Herein, we report three surgical models with mice aiming to induce reflux of gastric contents, duodenal contents or mixed contents. Surgical procedures and general principles have been described in detail. A researcher with surgical experience should be able to grasp the technique after a short period of practice. After surgery, most mice can survive and develop reflux esophagitis similar to that in humans. However, it should be noted that histological differences between mouse and human esophagus are the inherent limitations of these surgical models. If used for research on Barrett’s esophagus and adenocarcinoma, these procedures may need to be combined with genetic modifications.
Additional file 5 of Evaluating methodological approaches to assess the severity of infection with SARS-CoV-2 variants: scoping review and applications on Belgian COVID-19 data
Creators: name: Meurisse, Marjan
name: Van Oyen, Herman
name: Blot, Koen
name: Catteau, Lucy
name: Serrien, Ben
name: Klamer, Sofieke
name: Cauët, Emilie
name: Robert, Annie
name: Van Goethem, Nina
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Additional file 5: Figure S4. Documented previous SARS-CoV-2 infections of Belgian hospitalized COVID-19 patients registered in the Clinical Hospital Survey (CHS). (Left) Number of Belgian hospitalized COVID-19 patients with and without a documented previous infections, 7-day rolling average. (Right) Percentage of Belgian hospitalized COVID-19 patients with and without a documented previous infections, 7-day rolling average. Periods of dominance of SARS-CoV-2 variants (more than 50% presence in baseline surveillance) are indicated as areas on the plot.
On the mass-metallicity relation, velocity dispersion and gravitational well depth of GRB host galaxies
Creators: name: Arabsalmani, Maryam
name: Møller, Palle
name: Fynbo, Johan P. U.
name: Christensen, Lise
name: Freudling, Wolfram
name: Savaglio, Sandra
name: Zafar, Tayyaba
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We analyze a sample of 16 absorption systems intrinsic to long duration GRB host galaxies at $z \gtrsim 2$ for which the metallicities are known. We compare the relation between the metallicity and cold gas velocity width for this sample to that of the QSO-DLAs, and find complete agreement. We then compare the redshift evolution of the mass-metallicity relation of our sample to that of QSO-DLAs and find that also GRB hosts favour a late onset of this evolution, around a redshift of $\approx 2.6$. We compute predicted stellar masses for the GRB host galaxies using the prescription determined from QSO-DLA samples and compare the measured stellar masses for the four hosts where stellar masses have been determined from SED fits. We find excellent agreement and conclude that, on basis of all available data and tests, long duration GRB-DLA hosts and intervening QSO-DLAs are consistent with being drawn from the same underlying population. GRB host galaxies and QSO-DLAs are found to have different impact parameter distributions and we briefly discuss how this may affect statistical samples. The impact parameter distribution has two effects. First any metallicity gradient will shift the measured metallicity away from the metallicity in the centre of the galaxy, second the path of the sightline through different parts of the potential well of the dark matter halo will cause different velocity fields to be sampled. We report evidence suggesting that this second effect may have been detected.
description: 11 pages, 6 figures, 6 tables. Accepted for publication in MNRAS Main Journal. For the definitive version visit http://mnras.oxfordjournals.org/
Stochastic Service Network Design with Different Relay Patterns for Hyperconnected Relay Transportation
Creators: name: Li, Jingze
name: Liu, Xiaoyue
name: Dahan, Mathieu
name: Montreuil, Benoit
Publisher: name: Georgia Institute of Technology
Year: 2023
Subjects: Hyperconnected relay transportation
Logistics platform
Stochastic service network design
Short-haul truckers
Hour-of-service regulations
Demand uncertainty
Operational patterns
Consistent schedules
Hauling capacities
Physical internet

description: Presented at the 9th International Physical Internet Conference (IPIC 2023) 13-15 June 2023, Athens, Greece
description: Hyperconnected relay transportation enables using a relay system of short-haul drivers to deliver long-haul shipments collectively, which helps address root causes of trucker shortage issues by transforming working conditions with potentials of daily returning home, accessing consistent schedules, and facilitating load matching. This Paper investigates hyperconnected relay transportation as a sustainable solution to trucker shortage issues through a logistics platform. We propose a two-stage programming model to optimize consistent working schedules for short-haul drivers while minimizing transportation costs. The first stage involves opening services and contracting truckers under demand uncertainty, where each service has a service route and approximate service schedules adhering to USA federal short-haul hour-of-service regulations. The second stage assigns hauling capacities to open services and manages commodity shipping or outsourcing given the demand realization. We extend the model formulation to account for various operational patterns (e.g., freight loading and unloading or hauler swapping) and schedule consistency requirements (e.g., weekly or daily consistency). A scenario-based approach is employed to solve the model for a case study of automotive delivery in the Southeast USA region. The experimental results validate the proposed approach, and further explore the impact of stochastic demands, operational patterns, consistent schedules, and hauling capacities on hyperconnected service network design. This research aims to offer practical guidance to practitioners in the trucking industry.
Drinking water residence time in distribution networks and emergency department visits for gastrointestinal illness in Metro Atlanta, Georgia
Creators: name: Tinker, Sarah C.
name: Tolbert, Paige E.
name: Singer, Philip
name: Amirtharajah, Appiah
name: Moe, Christine L.
name: Flanders, W. Dana
name: Klein, Mitchel
name: Uber, Jim
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: We examined whether the average water residence time, the time it takes water to travel from the treatment plant to the user, for a zip code was related to the proportion of emergency department (ED) visits for gastrointestinal (GI) illness among residents of that zip code. Individual-level ED data were collected from all hospitals located in the five-county metro Atlanta area from 1993 to 2004. Two of the largest water utilities in the area, together serving 1.7 million people, were considered. People served by these utilities had almost three million total ED visits, 164,937 of them for GI illness. The relationship between water residence time and risk for GI illness was assessed using logistic regression, controlling for potential confounding factors, including patient age and markers of socioeconomic status (SES). We observed a modestly increased risk for GI illness for residents of zip codes with the longest water residence times compared to intermediate residence times (odds ratio (OR) for Utility 1 = 1.07, 95% confidence interval (CI) = 1.03, 1.10; OR for Utility 2 = 1.05, 95% CI = 1.02, 1.08). The results suggest that drinking water contamination in the distribution system may contribute to the burden of endemic GI illness.
Posterior Probabilities: Nonmonotonicity, Asymptotic Rates, Log-Concavity, and Turán's Inequality
Creators: name: Hart, Sergiu
name: Rinott, Yosef
Publisher: name: arXiv
Year: 2022
Subjects: subject: Statistics Theory (math.ST)
subject: Theoretical Economics (econ.TH)
subject: Probability (math.PR)
subject: FOS: Mathematics
subject: FOS: Economics and business

description: In the standard Bayesian framework data are assumed to be generated by a distribution parametrized by $θ$ in a parameter space $Θ$, over which a prior distribution $π$ is given. A Bayesian statistician quantifies the belief that the true parameter is $θ_{0}$ in $Θ$ by its posterior probability given the observed data. We investigate the behavior of the posterior belief in $θ_{0}$ when the data are generated under some parameter $θ_{1},$ which may or may not be the same as $θ_{0}.$ Starting from stochastic orders, specifically, likelihood ratio dominance, that obtain for resulting distributions of posteriors, we consider monotonicity properties of the posterior probabilities as a function of the sample size when data arrive sequentially. While the $θ_{0}$-posterior is monotonically increasing (i.e., it is a submartingale) when the data are generated under that same $θ_{0}$, it need not be monotonically decreasing in general, not even in terms of its overall expectation, when the data are generated under a different $θ_{1}.$ In fact, it may keep going up and down many times, even in simple cases such as iid coin tosses. We obtain precise asymptotic rates when the data come from the wide class of exponential families of distributions; these rates imply in particular that the expectation of the $θ_{0}$-posterior under $θ_{1}\neqθ_{0}$ is eventually strictly decreasing. Finally, we show that in a number of interesting cases this expectation is a log-concave function of the sample size, and thus unimodal. In the Bernoulli case we obtain this by developing an inequality that is related to Turán's inequality for Legendre polynomials.