cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
E-Commerce-Report Schweiz 2011: Eine Studie zur Entwicklung des Schweizer E-Commerce
Creators: name: Wölfle, Ralf
name: Leimstoll, Uwe
Publisher: name: Hochschule für Wirtschaft FHNW
Year: 2011
Subjects: subject: 330 - Wirtschaft
subject: 005 - Computer Programmierung, Programme und Daten

description: Der E-Commerce-Report beleuchtet die Entwicklung des B2C-E-Commerce aus Sicht von Schweizer Anbietern. Damit unterscheidet er sich von anderen E-Commerce-Studien, die meist auf Konsumentenbefragungen basieren. Die langfristig angelegte Studienreihe basiert auf jährlich durchgeführten Interviews mit Mitgliedern des E-Commerce Leader Panels Schweiz. Dieses Panel repräsentiert Unternehmen, die in ihrer Branche zu den führenden E-Commerce-Anbietern gehören oder durch herausragende Leistungen, z.B. Innovation, besondere Aufmerksamkeit auf sich gezogen haben. Das 2009 etablierte Panel wurde jährlich um einige neue Mitglieder erweitert. An der von Datatrans beauftragten Studie 2011 beteiligten sich insgesamt 23 Geschäftsführer oder E-Commerce-Verantwortliche. Mehr Infos unter www-e-commerce-report.ch
CCWI: F32 'A FAST METHOD TO IDENTIFY THE CRITICALITY OF INDIVIDUAL COMPONENTS IN WATER SUPPLY NETWORKS'
Creators: name: Meijer, Didrik
name: Francois Clemens
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: For the management of piped infrastructure (e.g. water supply networks, gas distribution systems) strategies are required to program the maintenance activities (e.g. repairs, replacement). In general, these activities are based on risk management that combines the probability and consequences of failure. In this paper a method is proposed to quickly identify the most critical elements in a network with respect to malfunctioning of a system as a whole. As opposed to methods applied so far, this method does not rely on iterative hydraulic calculations but takes the structure of the network as a starting point and is based on Graph theory. First the theory of the method is presented, secondly the first results are presented based on a water supply network and the outcomes are compared with traditional methods applied so far. Finally, the results are discussed and conclusions are formulated.
CCWI2017: F31 'Continuous robotic inspection of pipes for data rich asset management'
Creators: name: Thienen, Peter Van
name: Maks, Maurits
name: Doekle Yntema
name: Janssens, Jean-Paul
name: Bergmans, Bart
name: Diemel, Roel
name: Helgers, Michel
name: Horst, Peter
name: Trietsch, Eelco
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: An aging network in combination with stricter stakeholder requirements force the Dutch drinking water sector to improve the asset management of their water transport and distribution networks. Autonomous inspection robots (AIRs) provide a means to obtain knowledge on the condition of more pipes against lower cost, resulting in more focused rehabilitations and replacements, reduction of water loss through leakage, and a better knowledge and understanding of the system. In this paper, we describe the concept, a first prototype, and further steps that are currently being taken towards the development and application of this tool.
Additional file 1 of Preoperative prediction of pathological grade in pancreatic ductal adenocarcinoma based on 18F-FDG PET/CT radiomics
Creators: name: Xing, Haiqun
name: Hao, Zhixin
name: Zhu, Wenjia
name: Sun, Dehui
name: Ding, Jie
name: Zhang, Hui
name: Liu, Yu
name: Huo, Li
Publisher: name: figshare
Year: 2021
Subjects: subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences

description: Additional file 1: Supplement Fig. 1: Analysis flowchart. Supplement Table 1: Characteristics of patients with PDAC in the training set and validation set.
Management of checkpoint inhibitor-associated renal toxicities
Creators: name: Vanoverbeke, Lowie
name: Sprangers, Ben
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Cancer
subject: Hematology

description: Introduction: Checkpoint inhibitors have revolutionized the treatment of malignancies and are increasingly used in clinical practice. By inhibiting negative co-stimulatory signaling, checkpoint inhibitors result in augmented T cell activation and are, not surprisingly, commonly associated with various immune-related adverse events. Although renal immune-related adverse events are considered to be rare, these can be severe and sometimes require immunosuppressive treatment with or without discontinuation of checkpoint inhibitor therapy. Areas covered: In this review, we will focus on the diagnosis and management of checkpoint inhibitor-associated immune-related adverse events. We compile available data from published case reports and case series identified through an extensive search of PubMed, Web of Science and the Cochrane Library, and review of references of identified articles. Based on these data, we provide recommendations regarding renal monitoring in patients receiving checkpoint inhibitors and the treatment of these renal immune-related adverse events. Renal dysfunction in patients receiving checkpoint inhibitor treatment should not be readily attributed to checkpoint inhibitor treatment and a careful diagnostic work-up is needed in every affected patient. Expert commentary: We recommend performing a renal biopsy whenever important treatment decisions need to be taken to prevent unnecessary initiation of steroids and/or cessation of checkpoint inhibitory treatment.
CCWI2017: F143 'Fault Detection and Diagnosis for Pressure Control Valves in Water Supply Networks'
Creators: name: Jiramate Changklom
name: Stoianov, Ivan
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: The control of water supply networks is becoming more advanced and complex, and it is therefore increasingly important to continuously monitor and optimise the performance of automatic control valves. This paper investigates a method for early fault detection and diagnosis (FDD) of pressure control valves in water supply networks. Potential faults are categorised, and different process variables and residuals are defined from continuous measurements and model-based simulations of the operation of a diaphragm actuated globe valve in order to detect a fault and diagnose its likely cause. We generate and utilise experimental data from controlled laboratory conditions and an operational network together with numerically simulated data to validate the performance of the proposed FDD method.
CCWI2017: F14 'Pattern Recognition in Residential End Uses of Water Using Artificial Neural Networks and Other Machine-Learning Techniques'
Creators: name: Carranza, Juan Carlos Ibáñez
name: Morales, Roberto Díaz
name: Sánchez, Jose Antonio
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: Machine-Learning and other Artificial Intelligence techniques have nowadays many practical applications in engineering, science or everyday life. In the water industry, there is also a broad scope of potential applications. In this paper, it will be presented a system developed by Canal de Isabel II to identify residential use of water in its different appliances, based on records from precision water meters equipped with pulse emitters. Developed models are based on Support Vector Machines, and Artificial Neural Network paradigms. Training data sets for the models have been extracted from a sample of about 300 residential users in the Region of Madrid (Spain), monitored since 2008. In this time, more than 35 million of water use events have been registered and about 15 million hours of water consumption monitored. Machine-Learning techniques have proved to be an accurate and suitable method for automate this task that otherwise should require a huge number of man-hours of processing by operators.
Additional file 3 of Integrated CNV-seq, karyotyping and SNP-array analyses for effective prenatal diagnosis of chromosomal mosaicism
Creators: name: Ma, Na
name: Xi, Hui
name: Chen, Jing
name: Peng, Ying
name: Jia, Zhengjun
name: Yang, Shuting
name: Hu, Jiancheng
name: Pang, Jialun
name: Zhang, Yanan
name: Hu, Rong
name: Wang, Hua
name: Liu, Jing
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Additional file 3. Figure S2: Cases 36 and 41. Panel A. The CMA analysis of uncultured AF samples shows a normal result. The CNV‐seq profile of the same AF sample shows a low ratio of mosaic monosomy X (~8%). The CNV‐seq profiles of the maternal and fetal center of placenta show monosomy X with the level of 11% and 83% mosaicism. The blue line represents the mean copy number and the black box represents the centromere. Panel B. The CMA analysis on uncultured AF samples shows a normal result. The CNV‐seq profiles of the same AF samples shows a low ratio of mosaic monosomy X (~8%). The CNV‐seq profiles of the maternal and fetal center of placenta show monosomy X with the level of 15% and 78% mosaicism. The blue line represents the mean copy number and the black box represents the centromere.
Additional file 4 of Integrated CNV-seq, karyotyping and SNP-array analyses for effective prenatal diagnosis of chromosomal mosaicism
Creators: name: Ma, Na
name: Xi, Hui
name: Chen, Jing
name: Peng, Ying
name: Jia, Zhengjun
name: Yang, Shuting
name: Hu, Jiancheng
name: Pang, Jialun
name: Zhang, Yanan
name: Hu, Rong
name: Wang, Hua
name: Liu, Jing
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Additional file 4. Figure S3. Case 63 (normal karyotype). CMA and CNV-seq results were discordant with karyotyping. Panel A. CMA analysis on uncultured cord blood sample shows a 20.44 Mb mosaic duplication at chromosome 8p21.3p11.21 (~ 23% of cells) marked by arrow. Panel B. CNV-seq shows a mosaic 8p22p11.1 duplication of 25.3 Mb (~23% of cells). Positions of CNVs are indicated by the dashed boxes.
Additional file 1 of Trends in the prevalence of social isolation among middle and older adults in China from 2011 to 2018: the China Health and Retirement Longitudinal Study
Creators: name: Lin, Yanwei
name: Zhu, Tingting
name: Zhang, Xiaoyan
name: Zeng, Zhirong
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Science Policy
Mental Health

description: Additional file 1: Table S1. Variable assignment.
CCWI2017: F16 'Automatic Detection of Sewer Faults Using Continuous CCTV Footage'
Creators: name: Myrans, Joshua
name: Kapelan, Zoran
name: Everson, Richard
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: The work presented in the paper demonstrates the automatic detection of faults in sewers using CCTV footage. Specifically, it develops the fault detection methodology for application to a continuous video sequence, implementing a new ‘Smoothing’ stage. This new stage implements a Hidden Markov Model and Windowing technique, able to incorporate information from an entire CCTV segment to improve the frame by frame identification. The modified methodology was tested and demonstrated on footage taken from real world surveys in the UK. The results obtained, demonstrate that the extended methodology has improved performance with up to an 8% increase in accuracy and up to 5% increase in area under the ROC curve. Given the ability to produce predictions comparable to those of surveyors, the methodology shows promise for future application in industry.
Additional file 1: of Role of miR29c in goose fatty liver is mediated by its target genes that are involved in energy homeostasis and cell growth
Creators: name: Liu, Long
name: Wang, Qian
name: Wang, Qianqian
name: Zhao, Xing
name: Zhao, Pan
name: Geng, Tuoyu
name: Gong, Daoqing
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Computational Biology

description: Table S1. Data related to Fig. 3d*. (DOCX 14 kb)
Evaluation of the possible influence of Povidone Iodine (PVI) solution and Polyhexanide (PHMB) on wound healing in corneal epithelial regeneration
Creators: name: Foja, Sabine
name: Heinzelmann, Joana
name: Viestenz, Anja
name: Rueger, Christiane
name: Hecht, Sabine
name: Viestenz, Arne
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 610

description: This study investigates the possible toxic effects of the preoperative antiseptic substances povidone iodine (PVI) and polyhexanide (PHMB; Serasept® 2) on wound healing in ophthalmology. To assess this impact, human telomerase-immortalized corneal epithelial (hTCEpi) cells and human telomerase-immortalized conjunctival epithelial (hCjE) cells were exposed to 1% and 5% PVI or 0.04% PHMB for different periods to evaluate the cytotoxicity of these two antiseptics. Furthermore, the toxicity of these antiseptics was investigated in a human tissue-specific corneal epithelial construct and porcine eye culture model. The results reveal the high cytotoxicity of PVI and PHMB in the hTCEpi and hCjE in monolayer cell culture models, independent of the incubation time and concentration of these substances. However, after hTCEpi cell differentiation into a tissue-specific corneal epithelial construct, contact with these antiseptics for the relevant preoperative time did not alter cPARP1 or Ki67 expression. Furthermore, the wound-healing process in the porcine cornea was not significantly influenced after incubation with these antiseptics. In summary, corneal and conjunctival epithelial cell lines are very sensitive to PVI and PHMB, whereas no significant alterations were found in intact tissue-specific corneal epithelial constructs or porcine corneas. Therefore, we could not identify PVI and PHMB as reasons for postoperative eye irritation.
Effects of aqueous boundary layers and paracellular transport on the efflux ratio as a measure of active transport across cell layers
Creators: name: Kotze, Soné
name: Ebert, Andrea
name: Goss, Kai-Uwe
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 540

description: The efflux ratio (ER), determined by Caco-2/MDCK assays, is the standard in vitro metric to establish qualitatively whether a compound is a substrate of an efflux transporter. However, others have also enabled the utilisation of this metric quantitatively by deriving a relationship that expresses the ER as a function of the intrinsic membrane permeability of the membrane (𝑃0) as well as the permeability of carrier-mediated efflux (𝑃𝑝𝑔𝑝). As of yet, 𝑃𝑝𝑔𝑝 cannot be measured directly from transport experiments or otherwise, but the ER relationship provides easy access to this value if 𝑃0 is known. However, previous derivations of this relationship failed to consider the influence of additional transport resistances such as the aqueous boundary layers (ABLs) and the filter on which the monolayer is grown. Since single fluxes in either direction can be heavily affected by these experimental artefacts, it is crucial to consider the potential impact on the ER. We present a model that includes these factors and show both mathematically and experimentally that this simple ER relationship also holds for the more realistic scenario that does not neglect the ABLs/filter. Furthermore, we also show mathematically how paracellular transport affects the ER, and we experimentally confirm that paracellular dominance reduces the ER to unity and can mask potential efflux.
Indirect costs of diabetes and its impact on the public finance: the case of Poland
Creators: name: Torój, Andrzej
name: Mela, Aneta
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Science Policy
subject: 60506 Virology

description: Background: Growing public and private expenditure on healthcare results i.a. from the spreading of chronic diseases. Diabetes belongs to the most frequent ones, beyond neoplasms and cardiological diseases, and hence generates a significant burden for the public finance in terms of the direct costs. However, the economy suffers also from the indirect cost of diabetes that manifests itself in the loss in Gross Domestic Product (GDP) and general government revenues. Methods: This paper aims to measure this indirect cost, both in terms of GDP drop (social perspective) and public revenue drop (public finance perspective), in the case of Poland in 2012–2014. We use a modified human capital approach and unique dataset provided by the Social Security institution in Poland and the Polish Central Statistical Office. Results: Diabetes is a substantial and growing burden for the Polish economy. In the years 2012, 2013 and 2014 the indirect cost (output loss) amounted to 1.85 bn USD, 1.94 bn USD and 2.00 bn USD respectively. Conclusions: Estimated indirect cost of diabetes can be a useful input for health technology analyses of drugs or economic impact assessments of public health programmes.
Magnetic properties and THz emission from Co/CoO/Pt and Ni/NiO/Pt trilayers
Creators: name: Kanistras, Nikolaos
name: Scheuer, Laura
name: Anyfantis, Dimitrios I.
name: Barnasas, Alexandros
name: Torosyan, Garik
name: Beigang, René
name: Crisan, Ovidiu
name: Poulopoulos, Panagiotis
name: Papaioannou, Evangelos Th.
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 530

description: THz radiation emitted by ferromagnetic/non-magnetic bilayers is a new emergent field in ultra-fast spin physics phenomena with a lot of potential for technological applications in the terahertz (THz) region of the electromagnetic spectrum. The role of antiferromagnetic layers in the THz emission process is being heavily investigated at the moment. In this work, we fabricate trilayers in the form of Co/CoO/Pt and Ni/NiO/Pt with the aim of studying the magnetic properties and probing the role of very thin antiferromagnetic interlayers like NiO and CoO in transporting ultrafast spin current. First, we reveal the static magnetic properties of the samples by using temperature-dependent Squid magnetometry and then we quantify the dynamic properties with the help of ferromagnetic resonance spectroscopy. We show magnetization reversal that has large exchange bias values and we extract enhanced damping values for the trilayers. THz time-domain spectroscopy examines the influence of the antiferromagnetic interlayer in the THz emission, showing that the NiO interlayer in particular is able to transport spin current.
[Rezension von : Antonio Méndez Rubio. La escucha actual, 2022]
Creators: name: Karrer, Michael
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2024
Subjects: subject: 809

description: En La escucha actual, el poeta, ensayista y profesor universitario Antonio Méndez Rubio indaga en un terreno poco estudiado hasta ahora: la escucha. En contra del prejuicio generalizado que reduce la escucha a una forma pasiva de recepción, el autor insiste en la actividad fundamental que la caracteriza como práctica crítica y creativa. De este modo, reivindica la dimensión social y política del llamado “oído social” y muestra cómo éste se ve moldeado por las relaciones de poder al mismo tiempo que interviene activamente en ellas. La promesa de la escucha consiste en su apertura primordial a lo(s) otro(s), lo que la convierte en un elemento central de la vida en común. En tiempos de hiperestimulación visual y auditiva, la tarea de hacer oír la escucha y defenderla contra el asedio de la industria cultural y de las grandes corporaciones es de gran urgencia. El autor contrarresta esta forma de sordera social con una escucha a la vez sensible y desobediente, receptiva y combativa.
CCWI2017: F7 'Clustering-based Burst Detection Using Multiple Pressure Sensors in District Metering Areas'
Creators: name: Yipeng Wu
name: Shuming Liu
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: Bursts in water distribution systems (WDS) can cause water loss, service interruptions and other negative effects. However, it is challengeable for worldwide water utilities to timely be aware of bursts. This paper presents a novel burst detection approach using data from multiple pressure sensors in district metering areas (DMA). Differing from most data-driven methods that employ prediction models, this method utilizes a clustering algorithm to detect burst-induced data. Owing to the use of cosine distance in clustering analysis, temporal varying correlation between data from diffierent sensors is exploited, making the method only requires one day’s worth of data to implement. When applied to a DMA with three pressure sensors, the method successfully detected some real and simulated bursts over a period of two months.
title: 02_1838
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Specification of binding modes between a transmembrane peptide mimic of ATP6V0C and polytopic E5 of human papillomavirus-16
Creators: name: Dhani Ram Mahato
name: Fischer, Wolfgang B.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Computational Biology

description: Interaction of E5 of papillomavirus-16 based on its three transmembrane domains (TMDs) with a peptide mimicking the fourth TMD (TMD-A) of the 16 kDa c subunit of the human vacuolar H+-ATPase, ATP6V0C, and one of its mutant is investigated. Docking reveals binding of the peptide between the second and third TMD of E5. A series of hydrophobic residues are responsible for the contact. Estimated weak binding energies based on potential of mean force calculations reveal marginal differences of the estimated binding energies between wild type (WT) and mutant peptide. Also differences in estimated binding energies of dimers of the individual TMDs of E5 with the WT peptide are marginal. Correlation of rotational data derived from coarse-grained molecular dynamics simulations of the peptides and the protein as well as from the principal component analysis reveal that the binding of TMD-A with TMD3 is enthalpy driven and binding with TMD2 is guided by entropic conditions.
CCWI2017: F20 'Online Burst Detection in Water Networks With an Ensemble of Flow Prediction Models'
Creators: name: Adachi, Shingo
name: Takahashi, Shinsuke
name: Takemoto, Takeshi
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: Pipe bursts in water distribution networks have to be dealt with quickly so as to prevent secondary accidents and expansion of supply suspension. Online burst detection methods have been actively studied from within the framework that an anomaly is detected by assessing the deviation of actual sensor readings from the corresponding predictions. However, these methods might fail or take too long to detect a gradually developing burst because their predictions are based on sensor readings from recent periods that would be immediately affected by the burst. In this study, we adopt an ensemble of flow prediction models to detect both step-shaped and gradually developing bursts earlier. One prediction model using recent flow readings has a smaller prediction range, which enables earlier detection of step-shaped bursts, while another model using only the older flow readings can robustly detect gradually developing bursts. The proposed method forms an ensemble of the models with different usages of flow readings and takes advantage of the strengths of each so that it can detect bursts of various development rates earlier. As a case study, the proposed method was applied to a set of synthetic data of a DMA with 20m 3 /h inflow on average. It was found that half of the randomly generated gradually developing bursts were detected around when the development of the burst flow slowed down. It was also demonstrated that adopting the ensemble models actually reduced the amount of time it took to detect gradually developing bursts. A future task is the evaluation of the proposed method utilized for a real burst event.
Efficacy of Aerosol Reduction Measures for Dental Aerosol Generating Procedures
Creators: name: He, Zixin
name: Gao, Qiman
name: Henley, Anna
name: Der Khatchadourian, Zovinar
name: Somerville, Wendy
name: Wiseman, Michael
name: Mongeau, Luc
name: Tamimi, Faleh
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Aerosol particles generated by dental procedures could facilitate the transmission of infectious diseases and contain carcinogen particles. Such particles can penetrate common surgical masks and reach the lungs, leading to increased risk for dental care professionals. However, the risk of inhaling contaminated aerosol and the effectiveness of aerosol reduction measures in dental offices remain unclear. The present study aimed to quantify aerosols produced by drilling and scaling procedures and to evaluate present recommendations for aerosol reduction. The concentration of aerosol particles released from the mock scaling and drilling procedures on dental mannequin were measured using a TSI Optical Particle Sizer (OPS 3330) during 15-min sessions carried out in a single-patient examination room. Using a drilling procedure as the aerosol source, the aerosol reduction performance of two types of high-volume evacuators (HVEs) and a commercial off-the-shelf air purifier was evaluated in a simulated clinical setting. Using either HVEs or the air purifier individually reduced the aerosol accumulated over the course of a 15-minutes drilling procedure at a reduction rate of 94.8 to 97.6%. Using both measures simultaneously raised the reduction rate to 99.6%. The results show that existing HVEs can effectively reduce aerosol concentration generated by a drilling procedure and can be further improved by using an air purifier. Following current regulatory guidelines can ensure a low risk of inhaling contaminated aerosol for dentists, assistants, and patients.
Design, synthesis, and biological evaluation of triazole-pyrimidine-methylbenzonitrile derivatives as dual A2A/A2B adenosine receptor antagonists
Creators: name: Li, Zhi
name: Kou, Lijuan
name: Fu, Xinzhen
name: Xie, Zeping
name: Xu, Maolei
name: Guo, Lin
name: Lin, Tiantian
name: Gong, Shizhou
name: Zhang, Shumin
name: Liu, Ming
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biochemistry
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: A series of novel dual A2A/A2B AR antagonists based on the triazole-pyrimidine-methylbenzonitrile core were designed and synthesised. The A2A AR antagonist cAMP functional assay results were encouraging for most target compounds containing quinoline or its open-ring bioisosteres. In addition, compound 7i displayed better inhibitory activity on A2B AR (IC50 14.12 nM) and higher potency in IL-2 production than AB928. Moreover, molecular docking studies were carried out to explain the rationality of molecular design and the activity of compound 7i. Further studies on 7f and 7i revealed good liver microsomes stabilities and acceptable in vivo PK profiles. This study provides insight into the future development of dual A2A/A2B AR antagonists for cancer immunotherapy.
CCWI2017: F54 'Data-driven Approach to Short-Term Forecasting of Turbidity in a Trunk Main Network'
Creators: name: Meyers, Gregory
name: Kapelan, Zoran
name: Keedwell, Edward
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: Water discolouration is an increasingly important and expensive issue due stricter regulatory demands and ageing Water Distribution Systems (WDSs) in the UK and abroad. This paper presents a turbidity forecasting methodology capable of aiding operational staff and enabling proactive management strategies. The methodology presented here does not require a hydraulic or water quality network model that can be expensive to build and maintain. The methodology is tested and verified on a real UK trunk main network with observed turbidity measurement data. Results obtained show that the classification based forecasts of turbidity can reliably detect if discolouration material is mobilised up to 5 hours ahead. The methodology could be used as an early warning system to enable a range of proactive management strategies as an alternative to regular trunk mains cleaning.
CCWI2017: F115 'Online advanced uncertain reasoning architecture with binomial event discriminator system for novelty detection in smart water networks'
Creators: name: Mounce, Stephen
name: A. Fargus
name: M. Weeks
name: J. Young
name: D. Ejimbe
name: E. Goya
name: M. Holburn
name: T. Jackson
name: Boxall, Joseph
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: Minimising the loss of treated water from water supply systems due to bursts is an ongoing issue for water service providers around the world. Sensor technology and the ‘big data’ they generate combined with machine learning based analytics are providing an opportunity for automated event detection. AURA-Alert has been developed as an online (Software as a Service) system which automates the training data selection (by selecting data with acceptable Match Strength and with regular retraining). The addition of a Binomial Event Discriminator service can produce alerts based on windows of thresholded match distances. A pilot deployment on over 200 live data streams in the cloud has been deployed as part of the SmartWater4Europe project. Examples of analysis for real events are presented. For a historic subset of eight data streams over a three month period up to 58% of bursts were detected (depending on window used for evaluation). It is concluded that the system is an effective and viable tool for novelty detection for water network time series data with potential for wider applicability. Key strengths include lack of per site configuration, data-driven self-learning (from periods of normality), real-time, high scalability and full automation of model retraining.
Additional file 1 of Barriers and facilitators to accessing adolescents’ mental health services in Karachi: users and providers perspectives
Creators: name: Mubeen, Zainab
name: Fatmi, Zafar
name: Hameed, Waqas
name: Asim, Muhammad
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mental Health

description: Supplementary Material 1
CCWI2017: F78 'Evaluating Classification Algorithms for Improved Wastewater System Calibration'
Creators: name: Younis, Mohammed Chachan
name: Keedwell, Edward
name: Savic, Dragan
name: Raine, Anthony
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: Hydraulic models provide an approximate model of rainfall collection (storm), wastewater collection (foul), and combined (both rainfall and wastewater collections) network performance, capturing the large scale element of the system, but such systems require calibration with real world data to achieve reliable and accurate results. However, many factors surrounding real-world network and catchment characteristics are unknown and can influence the hydraulic performance of the network. Consequently, calibrating wastewater models to accurately reflect real-world conditions is a time consuming and complex process. This paper employs a two stage urban runoff forecasting approach with a combination of image classification techniques and modelling using InfoWorks ICM. The image classification section consists of the automated processing of the satellite image as an aid to modelling wastewater in the urban environment by classifying the land- cover as pervious and impervious segments of water from rainfall events. By classifying such areas with an urban catchment, and by using the Wallingford PR Equation across all tests of Area 1 (roads), 2 (roofs) and 3 (permeable area), we explore the potential for a partially automated network system calibration process of a wastewater network.
Additional file 2: of Role of miR29c in goose fatty liver is mediated by its target genes that are involved in energy homeostasis and cell growth
Creators: name: Liu, Long
name: Wang, Qian
name: Wang, Qianqian
name: Zhao, Xing
name: Zhao, Pan
name: Geng, Tuoyu
name: Gong, Daoqing
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Plant Biology
subject: Virology
subject: Computational Biology

description: Figure S1. The upstream sequence of goose miR29c. (A) The sequence of the amplified fragment. (B) The picture of the amplified fragment. The sequence was acquired from PCR-based amplification with primers (Table 1) designed based on the chicken sequence and following sequencing analysis. (DOCX 624 kb)
CCWI2017: F84 'Prediction of CSO Chamber Water Levels Using Rainfall Forecasts'
Creators: name: T. Rosin
name: M. Romano
name: K. Woodward
name: E. Keedwell
name: Z. Kapelan
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: CSOs are a major source of pollution, spilling untreated wastewater directly into water bodies and/or the environment. This paper describes an investigation of the use of rainfall forecasts when predicting water level in a Combined Sewer Overflow (CSO) chamber. A prediction model based on a multi-layer feed-forward Artificial Neural Network (ANN) with a sliding time-window of inputs was developed to model the relationship between contributing rainfall and water level within a CSO chamber and predict the occurrence of spills. Three versions of the aforementioned prediction model were developed and compared: 1) without using forecast rainfall data, 2) with perfect rainfall forecasts (i.e. forecasts assuming perfect knowledge of historical rainfall into the future) and 3) with real rainfall forecasts. These models were tested on a CSO located in the Wirral area of the United Utilities network and were all able to successfully predict CSO spills 2 hours ahead. Use of forecast radar rainfall data, generated by the Met Office, was shown to demonstrably improve the accuracy of the ANN predictions and increase the prediction range of the model. Unsurprisingly, this accuracy was further improved when using perfect rainfall forecast data, due to errors inherent in real forecasts. It is envisioned that ANN models could be beneficially used by water utilities for near real-time modelling of water level in CSO chambers and generate alerts for upcoming spills events. The use of forecast data increases the detection time of CSO discharges, potentially enabling water utilities to take appropriate and timely action to address potential issues before the customers and the environment are adversely effected.
CCWI2017: F121 'Effects of Manning Coefficients and Absolute Roughness on the Optimized Designs of Urban Drainage Networks'
Creators: name: Natalia Duque, V.
name: Carlos Montes, R.
name: Juan Zambrano, B.
name: Juan Saldarriaga, V.
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: Urban drainage networks are designed according to a series of regulations and methodologies that seek for an adequate operation of the system while transporting the urban wastewater and runoff. The design methodologies are founded in empirical or physically based flow resistance equations, such as Manning’s and Darcy-Weisbach’s equation, respectively. This work presents a statistical analysis over the costs obtained using the mentioned equations, considering different scenarios and materials. Furthermore, a comparison of the total construction costs was made to determine which methodology is the most appropriate for an urban drainage optimal design. The numerical examples were performed over two urban drainage networks with different topographical characteristics.
CCWI2017: F104 'Smart rainwater management systems powered by the internet of things: a UK case study'
Creators: name: Rezaei, Hossein
name: Melville-Shreeve, Peter
name: Butler, David
Publisher: name: The University of Sheffield
Year: 2017
Subjects: subject: 90599 Civil Engineering not elsewhere classified
subject: FOS: Civil engineering

description: Climate change is projected to significantly alter existing rainfall patterns. Traditional water and wastewater assets are unlikely to be able to respond to such events, particularly when factoring in increasing population growth. Novel source control and non-potable use strategies are required to limit the impacts of extreme events on water resources. A novel, smart Rainwater Management System (RMS) was developed by Over the Air Analytics Ltd. building on research conducted at University of Exeter. The technology sees the commercial application of emerging Internet of Things (IoT) protocols and communication platforms to manage rainwater at source to mitigate flooding and provide alternative water resources in urban settings. With new technologies in data gathering, communications, power management, and associated software, IoT systems can enable real-time management of water sector assets. In addition, the reducing cost of such technologies is enabling their deployment in a widening set of technical niches. In this paper, results from a trial with the Future Cities Catapult (London) are presented including high resolution data acquisition and analysis of an innovative smart RMS. Over a 4-month trial period, at a residential property, the smart RMS successfully attenuated the rainfall from several storm events, whilst enabling rainwater reuse for non-potable applications (i.e. WC flushing). Despite some gaps in the data, due to power and connectivity disruptions, the system showed a high degree of reliability, with little downtime. The study concludes that the use of IoT in RMS shows potential to increase the flexibility and resilience of water and wastewater assets by adapting to the challenges of climate changes in an affordable, reliable and scalable system.
Additional file 1 of METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation
Creators: name: Xue, Meilin
name: Dong, Lei
name: Zhang, Honghai
name: Li, Yangchan
name: Qiu, Kangqiang
name: Zhao, Zhicong
name: Gao, Min
name: Han, Li
name: Chan, Anthony K. N.
name: Li, Wei
name: Leung, Keith
name: Wang, Kitty
name: Pokharel, Sheela Pangeni
name: Qing, Ying
name: Liu, Wei
name: Wang, Xueer
name: Ren, Lili
name: Bi, Hongjie
name: Yang, Lu
name: Shen, Chao
name: Chen, Zhenhua
name: Melstrom, Laleh
name: Li, Hongzhi
name: Timchenko, Nikolai
name: Deng, Xiaolan
name: Huang, Wendong
name: Rosen, Steven T.
name: Tian, Jingyan
name: Xu, Lin
name: Diao, Jiajie
name: Chen, Chun-Wei
name: Chen, Jianjun
name: Shen, Baiyong
name: Chen, Hao
name: Su, Rui
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1. Supplementary tables and Figures.
title: Data Stewardship Maturity Report for NOAA JPSS Visible Infrared Imaging Radiometer Suite (VIIRS) Land Surface Reflectance Environmental Data Record (EDR) from NDE
Creators: name: Hager, Lori
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00145
title: Texte sans titre en anglais sur le sida
Creators: name: Leibowitch, Jacques
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Source: http://www.calames.abes.fr/pub/ms/Calames-2019311113283123
description: created: start=1975;end=2018
Additional file 1 of Biomechanical effects of Evans versus Hintermann osteotomy for treating adult acquired flatfoot deformity: a patient-specific finite element investigation
Creators: name: Xu, Can
name: Liu, Hua
name: Li, Mingqing
name: Li, Hui
name: Pan, Chun’ang
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology

description: Additional file 1. Table 1. Tibia, fibula and ankle ligament properties. Table 2. Calcaneus, talus and midfoot bone ligament properties. Table 3. Planter fascia and long/short planter ligament properties. Table 4. The arch height for normal, AAFD populations and our model. Table 5. The angle measurement for normal, AAFD populations and our model.
title: Data Stewardship Maturity Report for NOAA JPSS Visible Infrared Imaging Radiometer Suite (VIIRS) Volcanic Ash Detection and Height (VADH) Environmental Data Record (EDR) from NDE
Creators: name: Hager, Lori
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00141
title: Data Stewardship Maturity Report for NOAA JPSS Visible Infrared Imaging Radiometer Suite (VIIRS) Snow Cover Environmental Data Record (EDR) from NDE
Creators: name: Hager, Lori
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00140
Polyketides with different post-modifications from desert endophytic fungus Paraphoma sp.
Creators: name: L. Y. Li
name: B. D. Sun
name: G. S. Zhang
name: H. Deng
name: M. H. Wang
name: X. M. Tan
name: X. Y. Zhang
name: H. M. Jia
name: H. W. Zhang
name: T. Zhang
name: Z. M. Zou
name: G. Ding
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: Three new polyketides 4,6,8-trihydroxy-5-methyl-3,4-dihydronaphthalen-1(2H)-one (1), 5,7-dihydroxy-3-(1-hydroxyethyl)-3,4-dimethylisobenzofuran-1(3H)-one (2) and 1-(4-hydroxy-6-methoxy-1,7-dimethyl-3-oxo-1,3-dihydroisobenzofuran-1-yl) ethyl acetate (3) together with seven known analogues (4–10) were isolated from desert endophytic fungus Paraphoma sp. The structures of these compounds were elucidated by analysis of NMR data. The absolute configuration of (1–3) was established on the basis of CD experiments. The possible biosynthetic pathway of compounds (1–10) was suggested, which implied that these secondary metabolites might be originated from polyketide biosynthesis with different post-modification reactions. Compounds 2, and 5–8 were evaluated for bioactivities against plant pathogen A. solani, whereas none of them displayed any biological effects. In addition, compounds 1, 2 and 5–10 were also tested for cytotoxic activities against three human cancer cell lines (HepG2 cells, MCF-7 cells and Hela cells) without biological effects.
title: Data Stewardship Maturity Report for NOAA JPSS Visible Infrared Imaging Radiometer Suite (VIIRS) Nighttime Cloud Optical and Microphysical Properties (NCOMP) Environmental Data Record (EDR) from NDE
Creators: name: Hager, Lori
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00137
title: Data Stewardship Maturity Report for JPSS Visible Infrared Imaging Radiometer Suite (VIIRS) Enterprise Land Surface Temperature (LST) Environmental Data Record (EDR)
Creators: name: Hager, Lori
Publisher: name: National Centers for Environmental Information (U.S.)
Year: 2021

description: NOAA Technical Information Series NESDIS DSMR-00136