cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Die Braut In den Hohen Liederen Von Ihren Geliebten Zu der Hochzeit Des Unbefleckten Lambs eingeladen; [1758]
title: Vorgestellt in der vil Ehr- und Tugendreichen Jungfrauen Maria Anna Mayrhoverin, Des Wohledl- und Vesten Herrn Herrn Johann Wolfgang Mayrhovers, des Inneren Raths, und Beruquienmachers zu Landshut Jungfrau Tochter Als sie nach genommenen heldenmüthigen Abschied von der Welt, in dem strengen Orden S. Clarae Sich dem schneeweissen Lilgen-Chor beygesellet
titleType: Subtitle
Creators: name: Schallnkammer, Joseph David
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2014

description: Titelbl. in Rot- und Schwarzdr.
Dynamical Measurements of the Interior Structure of Exoplanets
Creators: name: Becker, Juliette C.
name: Batygin, Konstantin
Publisher: name: arXiv
Year: 2013
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Giant gaseous planets often reside on orbits in sufficient proximity to their host stars for the planetary quadrupole gravitational field to become non-negligible. In presence of an additional planetary companion, a precise characterization of the system's orbital state can yield meaningful constraints on the transiting planet's interior structure. However, such methods can require a very specific type of system. This paper explores the dynamic range of applicability of these methods and shows that interior structure calculations are possible for a wide array of orbital architectures. The HAT-P-13 system is used as a case study, and the implications of perturbations arising from a third distant companion on the feasibility of an interior calculation are discussed. We find that the method discussed here is likely to be useful in studying other planetary systems, allowing the possibility of an expanded survey of the interiors of exoplanets.
description: Accepted to ApJ
Towards Learnable Anchor for Deep Multi-View Clustering
Creators: name: Wang, Bocheng
name: Zeng, Chusheng
name: Chen, Mulin
name: Li, Xuelong
Publisher: name: arXiv
Year: 2025
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: Deep multi-view clustering incorporating graph learning has presented tremendous potential. Most methods encounter costly square time consumption w.r.t. data size. Theoretically, anchor-based graph learning can alleviate this limitation, but related deep models mainly rely on manual discretization approaches to select anchors, which indicates that 1) the anchors are fixed during model training and 2) they may deviate from the true cluster distribution. Consequently, the unreliable anchors may corrupt clustering results. In this paper, we propose the Deep Multi-view Anchor Clustering (DMAC) model that performs clustering in linear time. Concretely, the initial anchors are intervened by the positive-incentive noise sampled from Gaussian distribution, such that they can be optimized with a newly designed anchor learning loss, which promotes a clear relationship between samples and anchors. Afterwards, anchor graph convolution is devised to model the cluster structure formed by the anchors, and the mutual information maximization loss is built to provide cross-view clustering guidance. In this way, the learned anchors can better represent clusters. With the optimal anchors, the full sample graph is calculated to derive a discriminative embedding for clustering. Extensive experiments on several datasets demonstrate the superior performance and efficiency of DMAC compared to state-of-the-art competitors.
description: Accepted by AAAI25
Probing Hidden Sectors with Stückelberg U(1) Gauge Fields
Creators: name: Feng, Wan-Zhe
name: Shiu, Gary
name: Soler, Pablo
name: Ye, Fang
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We propose a framework in which visible matter interacts with matter from a hidden sector through mass mixings of Stückelberg U(1) gauge fields. In contrast to other Z' mediation scenarios, our setup has the added appealing features that (i) the choice of Z's can be significantly broadened without necessarily introducing unwanted exotic matter and (ii) there can be sizable tree-level interactions between the visible and hidden sectors. String theory embeddings of this scenario and their phenomenological features are briefly discussed.
description: 5 pages, 1 figure; minor corrections and title change to match with published version
Colorado stride (COSTRIDE): testing genetic and physiological moderators of response to an intervention to increase physical activity
Creators: name: Bryan, Angela
name: Magnan, Renee
name: Hooper, Ann E
name: Ciccolo, Joseph
name: Marcus, Bess
name: Hutchison, Kent
Publisher: name: Columbia University
Year: 2013
Subjects: subject: Exercise
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology

description: Background: The purpose of this research was to replicate a successful intervention to increase physical activity in a different region of the country, and explore genetic and physiological moderators of intervention efficacy drawn from a transdisciplinary theoretical framework. Method: A randomized controlled trial comparing a print-based physical activity intervention (COSTRIDE) to a print-based health and wellness contact control (HW) intervention was conducted. Sedentary participants (n = 219) completed assessments at baseline and follow-up assessments at 3, 6, 9, and 12 months following the initiation of the intervention. Results: Participants in both conditions significantly increased exercise behavior in the first six months, and then leveled off or decreased physical activity in the second six months of the study. Those in the COSTRIDE intervention increased significantly more than those in the HW intervention, and were better able to maintain their exercise behavior. Genetic factors (BDNF, rs6265; FTO, rs8044769), but not selected physiological (body temperature, blood lactate, systolic blood pressure, plasma norepinephrine, and heart rate) or subjective (perceived pain, affect) responses to physical activity, moderated response to the intervention. Conclusions: There are underlying genetic factors that influence response to behavioral intervention, and a better understanding of these factors has the potential to influence the development, targeting and tailoring of behavioral interventions to increase physical activity. Trial registration: Clinicaltrials.gov registration: NCT01091857.
Additional file 6 of Integrin alpha-2 and beta-1 expression increases through multiple generations of the EDW01 patient-derived xenograft model of breast cancer—insight into their role in epithelial mesenchymal transition in vivo gained from an in vitro model system
Creators: name: Wafai, Razan
name: Williams, Elizabeth D.
name: Souza, Emma De
name: Simpson, Peter T.
name: Reed, Amy E. McCart
name: Kutasovic, Jamie R.
name: Waltham, Mark
name: Snell, Cameron E.
name: Blick, Tony
name: Thompson, Erik W.
name: Hugo, Honor J.
Publisher: name: figshare
Year: 2020
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Additional file 6: Supplementary Fig. 6 EGF treatment (10 ng/ml, 72 h) of PMC42-ET breast cancer cells resulted in an EMT which associated with an upregulation (trend only) of ITGB1, ITGA2 and ILK. A. Phase contrast morphology, B. gene expression changes as assessed by RT-qPCR. Results are from one experiment, representative of two independent experiments. Error bars are standard deviation of n = 3 technical replicates within 1 biological replicate (1 experiment). C. Western blotting for vimentin, E-cadherin, and actin across the EGF time course. Scale bar, 100 μm.
Wikidata for the Cultural Heritage of the Province of L'Aquila
Creators: name: Adamou, Alessandro
name: Bastianelli, Elisa
name: Pasqualetti, Cristina
name: Werner, Klaus
Publisher: name: Zenodo
Year: 2025
Subjects: subject: Art history
subject: Wikidata
subject: Cultural heritage

description: Art History Loves Wiki 2025 – Collections, Archives & Research Data

Conference, Munich/online, January 10–12, 2025

PresentationBy: Alessandro Adamou, Elisa Bastianelli, Cristina  Pasqualetti, Klaus WernerWith help by: Margherita Antolini, Arianna Artioli, Diana Sainz Camayd, Diletta Haberl
Aspirin Adherence, Depression and One-Year Prognosis after Acute Coronary Syndrome
Creators: name: Rieckmann, Nina
name: Burg, Matthew M.
name: Kronish, Ian M.
name: Chaplin, William F.
name: Schwartz, Joseph E.
name: Davidson, Karina W.
Publisher: name: Columbia University
Year: 2011
Subjects: Coronary heart disease
Patient compliance
Depression, Mental--Treatment
Mental health
Medical sciences
Medicine

description: In survivors of acute coronary syndromes (ACS; unstable angina or myocardial infarction), depression is highly prevalent [1] and increases the risk of adverse medical outcomes, independent of other prognostic risk markers [2, 3] . After ACS, adherence to recommended medications (e.g. aspirin, statins and -blockers) is crucial to prevent recurrent events or mortality [4–6], yet rates of adherence to these medications are poor [7–9] . Depressed patients are especially likely to be poorly adherent [8–11] . Thus, poor medication adherence may explain some of the increased risk of depression and adverse clinical outcomes after ACS.
Dual Halos and Formation of Early-Type Galaxies
Creators: name: Park, Hong Soo
name: Lee, Myung Gyoon
Publisher: name: arXiv
Year: 2013
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present a determination of the two-dimensional shape parameters of the blue and red globular cluster systems (GCSs) in a large number of elliptical galaxies and lenticular galaxies (early-type galaxies, called ETGs). We use a homogeneous data set of the globular clusters in 23 ETGs obtained from the HST/ACS Virgo Cluster Survey. The position angles of both blue and red GCSs show a correlation with those of the stellar light distribution, showing that the major axes of the GCSs are well aligned with those of their host galaxies. However, the shapes of the red GCSs show a tight correlation with the stellar light distribution as well as with the rotation property of their host galaxies, while the shapes of the blue GCSs do much less. These provide clear geometric evidence that the origins of the blue and red globular clusters are distinct and that ETGs may have dual halos: a blue (metal-poor) halo and a red (metal-rich) halo. These two halos show significant differences in metallicity, structure, and kinematics, indicating that they are formed in two distinguishable ways. The red halos might have formed via dissipational processes with rotation, while the blue halos are through accretion.
description: 15 pages, 4 figues, Accepted for publication in the Astrophysical Journal Letters
The Complex Angle in Normed Spaces
Creators: name: Thürey, Volker W.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 46B20, 46C05, 30E99

description: We consider a generalized angle in complex normed vector spaces. Its definition corresponds to the definition of the well known Euclidean angle in real inner product spaces. Not surprisingly it yields complex values as `angles'. This `angle' has some simple properties, which are known from the usual angle in real inner product spaces. But to do ordinary Euclidean geometry real angles are necessary. We show that even in a complex normed space there are many pure real valued `angles'. The situation improves yet in inner product spaces. There we can use the known theory of orthogonal systems to find many pairs of vectors with real angles, and to do geometry which is based on the Greeks 2000 years ago.
description: 21 pages
Thermalization in backgrounds with hyperscaling violating factor
Creators: name: Alishahiha, Mohsen
name: Astaneh, Amin Faraji
name: Mozaffar, M. Reza Mohammadi
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We present an analytic solution of a Vaidya-charged black hole with a hyperscaling violating factor in an Einstein-Maxwell-dilaton model, where the scalar potential plays a key role in the existence of the solution. By making use of this result, we study the process of thermalization after a global quench in a theory which its gravitational description is provided by the resultant solution in the case of zero charge. In particular, we probe the system by entanglement entropy and show that it exhibits certain scaling behaviors during the process.
description: 21 pages, v2: refs added, few comments added, typos corrected, v3: an Appendix added, to appear in PRD
Moreira de Sá, A., Chartularium Universitatis Portucalensis (1288-1537). Volume III (1409-1430). Ed. do Instituto de Alta Cultura (Centro de Estudos de Psicologia e de História da Filosofia anexo à Faculdade de Letras da Universidade de Lisboa)
Creators: name: Arieiro, José
Publisher: name: Theologica
Year: 1970

description: Theologica, v. 5 n. 4 (1970)
Serotonin Reuptake Inhibitor Use, Depression, and Long-Term Outcomes After an Acute Coronary Syndrome: A Prospective Cohort Study
Creators: name: Rieckmann, Nina
name: Kronish, Ian M.
name: Shapiro, Peter A.
name: Whang, William
name: Davidson, Karina W.
Publisher: name: Columbia University
Year: 2013
Subjects: Depression, Mental--Treatment
Coronary heart disease
Serotonin uptake inhibitors
Mental health
Medical sciences
Medicine

description: Depression is highly prevalent among patients with coronary heart disease.1 Selective serotonin reuptake inhibitors (SSRIs) are recommended as first-line antidepressant treatments for this population.2,3 Whereas there is a long-standing notion that SSRIs may improve cardiac disease prognosis by inhibiting platelet aggregation, SSRI use may also worsen prognosis by increasing bleeding4 or increasing the risk for arrhythmia.5

Only a few small randomized clinical trials with a total of 801 patients have assessed the efficacy of SSRIs in patients with a cardiac condition.6,7 Although no evidence for harm was detected in 2 meta-analyses, the follow-up periods for adverse cardiac events in these trials did not extend beyond 6 months, and patient samples were highly selected (ie, only patients not already receiving antidepressant therapy in usual care were included, and patients with comorbid conditions were excluded).

In a cohort of patients with acute coronary syndrome (ACS), we evaluated the association of SSRI and non-SSRI second-generation antidepressant use with the occurrence of cardiac events and mortality during a median follow-up period of 40 months.
Lightlike Membranes in Black Hole and Wormhole Physics, and Cosmology
Creators: name: Guendelman, Eduardo
name: Kaganovich, Alexander
name: Nissimov, Emil
name: Pacheva, Svetlana
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We shortly outline the principal results concerning the reparametrization-invariant world-volume Lagrangian formulation of lightlike brane dynamics and its impact as a source for gravity and (nonlinear) electromagnetism in black hole and wormhole physics.
description: 6 pages, talk at Second Bulgarian National Congress in Physics, Sept. 2013
Accuracy of the diagnosis of malignant hyperthermia in hospital discharge records
Creators: name: Pinyavat, Teeda
name: Rosenberg, Henry
name: Lang, Barbara
name: Wong, Cynthia
name: Riazi, Sheila
name: Brady, Joanne E.
name: Sun, Lena S. Y.
name: Li, Guohua
Publisher: name: Columbia University
Year: 2014
Subjects: Hospitals--Admission and discharge
Malignant hyperthermia
Anesthesiology
Medicine

description: Background: In 1997, the International Classification of Diseases, 9th Revision Clinical Modification (ICD-9CM) coding system introduced the code for malignant hyperthermia (MH) (995.86). The aim of the current study was to estimate the accuracy of coding for MH in hospital discharge records. Materials and methods: A panel of anesthesiologists expert in MH, reviewed medical records for patients with a discharge diagnosis of MH based on ICD-9 or ICD-10 codes from January 1, 2006 to December 31, 2008 at six tertiary care medical centers in North America. All cases were categorized as possible, probable, or fulminant MH, history of MH (family or personal) or other. Results: A total of 47 medical records were identified and reviewed by three experts. The mean age of patients was 40 years and 49% were male. A surgical procedure with general anesthesia was documented in 68% of patients. However, only 23.4% were judged to have had a possible, probable, or fulminant MH event. Dantrolene was given in 81% of MH cases. Family and personal history of MH accounted for 46.8% of cases. High fever without evidence of MH during admission accounted for 23.4%, and in 6.4% cases the reason for the code was not apparent. All patients judged to have an incident MH event survived to discharge. Conclusions: Medical record coding for MH typically includes both incident cases as well as a history of MH. The positive predictive value of about 70% for MH in this study are consistent with other studies of ICD-9 accuracy in the US. However, epidemiologic studies based on coded diagnosis of MH should carefully distinguish between incident cases related to anesthesia, cases unrelated to anesthesia and diagnosis based on history only.
title: Rarum Fraterni Amoris Exemplum; 1754
title: Das ist Seltenes Beyspiel Aufrichtiger Bruder-Liebe Auf offentlicher Schau-Bühne Vorgestellt Von dem Churfürstlichen Lyceo Societatis Jesu Zu Landshut den 4. und 6. Herbstmonats 1754 ...
titleType: Subtitle
Creators: name: Schlecht, Franz
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2014

description: Text lat., dt.
Studying moderators of implementation: analysis from an intervention to reduce disrespect and abuse in facility-based childbirth
Creators: name: Ramsey, Kate
name: Moyo, Wema
name: Mbuyita, Selemani
name: Kujawski, Stephanie Allison
name: Mbaruku, Godfrey
name: Freedman, Lynn P.
Publisher: name: Columbia University
Year: 2014
Subjects: Women's health services
Childbirth
Public health
Medical sciences

description: Background: Across the globe, women who deliver in health facilities report experiencing disrespect and abuse (D&A). In low- and middle-income countries, D&A is particularly catastrophic because it may cause women to opt against facility delivery, as well as violate their human rights. D&A is likely a frontline manifestation of multi-level problems in complex health systems; yet efforts to address D&A have typically focused on micro-levels - either health providers’ ethics or users’ demand for quality care. These have rarely achieved sustainable implementation mirroring clinical quality improvement challenges. Implementation science holds promise for investigating these challenges. The Consolidated Framework for Implementation Research (CFIR) assembles constructs from across the literature that can guide inquiry. Materials and methods: The Staha Project studies the magnitude and dimensions of D&A, and is testing mechanisms for its mitigation. It is based in two Tanzanian districts, with one assigned to intervention. Implementation is conducted by four facilities, catchment communities and local leadership. Implementation research includes patient and provider satisfaction surveys, observations, reports and qualitative interviews. Relevant CFIR constructs were selected to develop the lines of inquiry and as themes for qualitative analysis adapted iteratively based on data. We conducted descriptive analyses of quantitative data. Results: The intervention was developed through a participatory process grounded in baseline research to address meso- and micro-level drivers at the district level. A change process was elaborated including activation of a client service charter and a facility-based change process. Mutuality of respect emerged as the underlying value for the process. Results from the planning process and the first year of implementation will be presented using CFIR constructs. These will include findings related to the characteristics of the intervention, inner and outer settings, individual implementers and the process. Conclusions: The CFIR was a useful tool to establish lines of inquiry and frame analysis. Ongoing analysis permitted identification of areas for improvement. We found the strongest constructs were regarding the intervention, the individual, and the inner setting characteristics. The outer setting construct could be further developed, especially for interventions that go beyond health facilities.
Broad Absorption Line Variability on Multi-Year Timescales in a Large Quasar Sample
Creators: name: Ak, N. Filiz
name: Brandt, W. N.
name: Hall, P. B.
name: Schneider, D. P.
name: Anderson, S. F.
name: Hamann, F.
name: Lundgren, B. F.
name: Myers, Adam D.
name: Paris, I.
name: Petitjean, P.
name: Ross, Nicholas P.
name: Shen, Yue
name: York, Don
Publisher: name: arXiv
Year: 2013
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present a detailed investigation of the variability of 428 C IV and 235 Si IV Broad Absorption Line (BAL) troughs identified in multi-epoch observations of 291 quasars by the Sloan Digital Sky Survey-I/II/III. These observations primarily sample rest-frame timescales of 1-3 yr over which significant rearrangement of the BAL wind is expected. We derive a number of observational results on, e.g., the frequency of BAL variability, the velocity range over which BAL variability occurs, the primary observed form of BAL-trough variability, the dependence of BAL variability upon timescale, the frequency of BAL strengthening vs. weakening, correlations between BAL variability and BAL-trough profiles, relations between C IV and Si IV BAL variability, coordinated multi-trough variability, and BAL variations as a function of quasar properties. We assess implications of these observational results for quasar winds. Our results support models where most BAL absorption is formed within an order-of-magnitude of the wind-launching radius, although a significant minority of BAL troughs may arise on larger scales. We estimate an average lifetime for a BAL trough along our line-of-sight of a few thousand years. BAL disappearance and emergence events appear to be extremes of general BAL variability, rather than being qualitatively distinct phenomena. We derive the parameters of a random-walk model for BAL EW variability, finding that this model can acceptably describe some key aspects of EW variability. The coordinated trough variability of BAL quasars with multiple troughs suggests that changes in "shielding gas" may play a significant role in driving general BAL variability.
description: 34 pages, 29 figures. Review study. ApJ, in press
Review of ‘Clean Hands Save Lives’, written by Thierry Crouzet
Creators: name: Larson, Elaine L.
Publisher: name: Columbia University
Year: 2014
Subjects: Hand washing
Epidemiology
Public health

description: The concept that a ‘tipping point’ occurs when a behaviour or cultural norm reaches a threshold when sufficient knowledge, information, expectation and/or peer pressure is amassed is beautifully illustrated in this book, which tells the story of Dr. Pittet’s hand hygiene journey. Malcolm Gladwell popularized this idea in his 2000 bestseller, “The Tipping Point: How Little Things Can Make A Big Difference”. In his book, Mr. Gladwell uses the
example of an epidemic such as measles which starts with a very few cases, but reaches a point at which the spread is rapid and daunting in its scope. Crouzet’s book has produced an easy-to-read narrative of Dr. Pittet’s tipping
point contributions to global health through his work on hand hygiene.
Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo
Creators: name: An, Kyongman
name: Klyubin, Igor
name: Kim, Youngkyu
name: Jung, Jung
name: Mably, Alexandra
name: O’Dowd, Sean
name: Lynch, Timothy
name: Kanmert, Daniel
name: Lemere, Cynthia
name: Finan, Gina M.
name: Park, Joon
name: Kim, Tae-Wan
name: Walsh, Dominic
name: Rowan, Michael
name: Kim, Joung-Hun
Publisher: name: Columbia University
Year: 2013
Subjects: Alzheimer's disease
Neuroplasticity
Cytology
Pathology

description: Background: Exosomes, small extracellular vesicles of endosomal origin, have been suggested to be involved in both the metabolism and aggregation of Alzheimer’s disease (AD)-associated amyloid β-protein (Aβ). Despite their ubiquitous presence and the inclusion of components which can potentially interact with Aβ, the role of exosomes in regulating synaptic dysfunction induced by Aβ has not been explored. Results: We here provide in vivo evidence that exosomes derived from N2a cells or human cerebrospinal fluid can abrogate the synaptic-plasticity-disrupting activity of both synthetic and AD brain-derived Aβ. Mechanistically, this effect involves sequestration of synaptotoxic Aβ assemblies by exosomal surface proteins such as PrPC rather than Aβ proteolysis. Conclusions: These data suggest that exosomes can counteract the inhibitory action of Aβ, which contributes to perpetual capability for synaptic plasticity.
Banfi, Antonio, Esegesi e letture Kantiane. Vol. I. Traduzioni e commenti da «Prolegomeni» «Fondazione della metafísica del costumi» «Crítica del giudizio» a cura dl Nicola De Sanotis. Vol. II. Studi Mitici su Kant e il Kantismo a cura di Li no Rossi
Creators: name: Paula, Manuel António De
Publisher: name: Theologica
Year: 1970

description: Theologica, v. 5 n. 4 (1970)
From Brans-Dicke gravity to a geometrical scalar-tensor theory
Creators: name: Almeida, T. S.
name: Pucheu, M. L.
name: Romero, C.
name: Formiga, J. B.
Publisher: name: arXiv
Year: 2013
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We consider an approach to Brans-Dicke theory of gravity in which the scalar field has a geometrical nature. By postulating the Palatini variation, we find out that the role played by the scalar field consists in turning the space-time geometry into a Weyl integrable manifold. This procedure leads to a scalar-tensor theory that differs from the original Brans-Dicke theory in many aspects and presents some new features.
description: 21 pages
Towards an integrated approach for understanding glia in amyotrophic lateral sclerosis.
Creators: name: Majewski, Stanislaw
name: Klein, Pierre
name: Boillée, Séverine
name: Clarke, Benjamin E
name: Patani, Rickie
Publisher: name: The Francis Crick Institute
Year: 2025
Subjects: classificationCode: Stem Cells
subject: Stem Cells
classificationCode: Gene Expression
subject: Gene Expression
classificationCode: Computational & Systems Biology
subject: Computational & Systems Biology
classificationCode: Neurosciences
subject: Neurosciences
subject: FOS: Clinical medicine
classificationCode: Human Biology & Physiology
subject: Human Biology & Physiology
classificationCode: Model organisms
subject: Model organisms
classificationCode: Biochemistry & Proteomics
subject: Biochemistry & Proteomics
classificationCode: Cell Biology
subject: Cell Biology

description: Substantial advances in technology are permitting a high resolution understanding of the salience of glia, and have helped us to transcend decades of predominantly neuron-centric research. In particular, recent advances in 'omic' technologies have enabled unique insights into glial biology, shedding light on the cellular and molecular aspects of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Here, we review studies using omic techniques to attempt to understand the role of glia in ALS across different model systems and post mortem tissue. We also address caveats that should be considered when interpreting such studies, and how some of these may be mitigated through either using a multi-omic approach and/or careful low throughput, high fidelity orthogonal validation with particular emphasis on functional validation. Finally, we consider emerging technologies and their potential relevance in deepening our understanding of glia in ALS.
title: Alexius Oder Neue Kunst Die Welt zu betrügen; [1752]
title: Fürgestellt Von dem Churfürstlichen Lyceo Der Gesellschafft Jesu Zu Landshut Den 4. und 6. Herbstmonats M.DCC.LII. ...
titleType: Subtitle
Creators: name: Hagerer, Franciscus Salesius Ignatius
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2014

description: Perioche
PGC-1α supports glutamine metabolism in breast cancer
Creators: name: McGuirk, Shawn
name: Gravel, Simon-Pierre
name: Deblois, Geneviève
name: Papadopoli, David
name: Faubert, Brandon
name: Wegner, André
name: Hiller, Karsten
name: Avizonis, Daina
name: Akavia, Uri-David
name: Jones, Russell
name: Giguère, Vincent
name: St-Pierre, Julie
Publisher: name: Columbia University
Year: 2013
Subjects: subject: Glutamine--Metabolism
subject: Breast--Cancer
subject: Genetics
subject: FOS: Biological sciences
subject: Medical sciences

description: Background: Glutamine metabolism is a central metabolic pathway in cancer. Recently, reductive carboxylation of glutamine for lipogenesis has been shown to constitute a key anabolic route in cancer cells. However, little is known regarding central regulators of the various glutamine metabolic pathways in cancer cells. Methods: The impact of PGC-1α and ERRα on glutamine enzyme expression was assessed in ERBB2+ breast cancer cell lines with quantitative RT-PCR, chromatin immunoprecipitation, and immunoblotting experiments. Glutamine flux was quantified using 13C-labeled glutamine and GC/MS analyses. Functional assays for lipogenesis were performed using 14C-labeled glutamine. The expression of glutamine metabolism genes in breast cancer patients was determined by bioinformatics analyses using The Cancer Genome Atlas. Results: We show that the transcriptional coactivator PGC-1α, along with the transcription factor ERRα, is a positive regulator of the expression of glutamine metabolism genes in ERBB2+ breast cancer. Indeed, ERBB2+ breast cancer cells with increased expression of PGC-1α display elevated expression of glutamine metabolism genes. Furthermore, ERBB2+ breast cancer cells with reduced expression of PGC-1α or when treated with C29, a pharmacological inhibitor of ERRα, exhibit diminished expression of glutamine metabolism genes. The biological relevance of the control of glutamine metabolism genes by the PGC-1α/ERRα axis is demonstrated by consequent regulation of glutamine flux through the citric acid cycle. PGC-1α and ERRα regulate both the canonical citric acid cycle (forward) and the reductive carboxylation (reverse) fluxes; the latter can be used to support de novo lipogenesis reactions, most notably in hypoxic conditions. Importantly, murine and human ERBB2+ cells lines display a significant dependence on glutamine availability for their growth. Finally, we show that PGC-1α expression is positively correlated with that of the glutamine pathway in ERBB2+ breast cancer patients, and high expression of this pathway is associated with reduced patient survival. Conclusions: These data reveal that the PGC-1α/ERRα axis is a central regulator of glutamine metabolism in ERBB2+ breast cancer. This novel regulatory link, as well as the marked reduction in patient survival time associated with increased glutamine pathway gene expression, suggests that targeting glutamine metabolism may have therapeutic potential in the treatment of ERBB2+ breast cancer.
A remark on the connectedness of spheres in Cayley graphs
Creators: name: Gournay, Antoine
Publisher: name: arXiv
Year: 2014
Subjects: subject: Group Theory (math.GR)
subject: FOS: Mathematics

description: The aim of this small note is to prove an elementary yet useful properties of finitely presented groups. Let G be a finitely generated group with one end. Fix a (finite) generating set and let $B_n$ be the ball of radius $n$ around $e$. Let $B_n^{c,\infty}$ be the infinite connected component of the complement of $B_n$. Then G has connected spheres if there exists a $r >0$ such that $B_{n+r} \cap B_n^{c,\infty}$ is connected for all $n \geq 0$. This note shows that if G is finitely presented then it has connected spheres.
description: 5p., 1 figure
Variants in exons and in transcription factors affect gene expression in trans
Creators: name: Kreimer, Anat
name: Pe'er, Itshack G.
Publisher: name: Columbia University
Year: 2013
Subjects: subject: Gene regulatory networks
subject: Gene expression
subject: Genetics
subject: FOS: Biological sciences
subject: Biology--Classification

description: Background: In recent years many genetic variants (eSNPs) have been reported as associated with expression of transcripts in trans. However, the causal variants and regulatory mechanisms through which they act remain mostly unknown. In this paper we follow two kinds of usual suspects: SNPs that alter coding regions or transcription factors, identifiable by sequencing data with transcriptional profiles in the same cohort. We show these interpretable genomic regions are enriched for eSNP association signals, thereby naturally defining source-target gene pairs. We map these pairs onto a protein-protein interaction (PPI) network and study their topological properties. Results: For exonic eSNP sources, we report source-target proximity and high target degree within the PPI network. These pairs are more likely to be co-expressed and the eSNPs tend to have a cis effect, modulating the expression of the source gene. In contrast, transcription factor source-target pairs are not observed to have such properties, but instead a transcription factor source tends to assemble into units of defined functional roles along with its gene targets, and to share with them the same functional cluster of the PPI network. Conclusions: Our results suggest two modes of trans regulation: transcription factor variation frequently acts via a modular regulation mechanism, with multiple targets that share a function with the transcription factor source. Notwithstanding, exon variation often acts by a local cis effect, delineating shorter paths of interacting proteins across functional clusters of the PPI network.
Transcriptome sequencing and microarray design for functional genomics in the extremophile Arabidopsis relative Thellungiella salsuginea (Eutrema salsugineum)
Creators: name: Lee, Yang
name: Giorgi, Federico M.
name: Lohse, Marc
name: Kvederaviciute, Kotryna
name: Klages, Sven
name: Usadel, Björn
name: Meskiene, Irute
name: Reinhardt, Richard
name: Hincha, Dirk
Publisher: name: Columbia University
Year: 2013
Subjects: Plant gene expression
Genomics
Botany
Molecular biology

description: Background: Most molecular studies of plant stress tolerance have been performed with Arabidopsis thaliana, although it is not particularly stress tolerant and may lack protective mechanisms required to survive extreme environmental conditions. Thellungiella salsuginea has attracted interest as an alternative plant model species with high tolerance of various abiotic stresses. While the T. salsuginea genome has recently been sequenced, its annotation is still incomplete and transcriptomic information is scarce. In addition, functional genomics investigations in this species are severely hampered by a lack of affordable tools for genome-wide gene expression studies. Results: Here, we report the results of Thellungiella de novo transcriptome assembly and annotation based on 454 pyrosequencing and development and validation of a T. salsuginea microarray. ESTs were generated from a non-normalized and a normalized library synthesized from RNA pooled from samples covering different tissues and abiotic stress conditions. Both libraries yielded partially unique sequences, indicating their necessity to obtain comprehensive transcriptome coverage. More than 1 million sequence reads were assembled into 42,810 unigenes, approximately 50% of which could be functionally annotated. These unigenes were compared to all available Thellungiella genome sequence information. In addition, the groups of Late Embryogenesis Abundant (LEA) proteins, Mitogen Activated Protein (MAP) kinases and protein phosphatases were annotated in detail. We also predicted the target genes for 384 putative miRNAs. From the sequence information, we constructed a 44 κ Agilent oligonucleotide microarray. Comparison of same-species and cross-species hybridization results showed superior performance of the newly designed array for T. salsuginea samples. The developed microarrays were used to investigate transcriptional responses of T. salsuginea and Arabidopsis during cold acclimation using the MapMan software. Conclusions: This study provides the first comprehensive transcriptome information for the extremophile Arabidopsis relative T. salsuginea. The data constitute a more than three-fold increase in the number of publicly available unigene sequences and will greatly facilitate genome annotation. In addition, we have designed and validated the first genome-wide microarray for T. salsuginea, which will be commercially available. Together with the publicly available MapMan software this will become an important tool for functional genomics of plant stress tolerance.
Interacting dark sector with variable vacuum energy
Creators: name: Chimento, Luis P.
name: Richarte, Martín G.
name: García, Iván E. Sánchez
Publisher: name: arXiv
Year: 2013
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We examine a cosmological scenario where dark matter is coupled to a variable vacuum energy while baryons and photons are two decoupled components for a spatially flat Friedmann-Robertson-Walker spacetime. We apply the $χ^{2}$ method to the updated observational Hubble data for constraining the cosmological parameters and analyze the amount of dark energy in the radiation era. We show that our model fulfills the severe bound of $Ω_{x}(z\simeq 1100)<0.009$ at the $2σ$ level, so it is consistent with the recent analysis that includes cosmic microwave background anisotropy measurements from the Planck survey, the Atacama Cosmology Telescope, and the South Pole Telescope along with the future constraints achievable by the Euclid and CMBPol experiments, and fulfills the stringent bound $Ω_{x}(z\simeq 10^{10})<0.04$ at the $2σ$ level in the big-bang nucleosynthesis epoch.
description: 5 pages,3 figures, 2 tables. (http://prd.aps.org/abstract/PRD/v88/i8/e087301)
An integrated strategy for efficient vector construction and multi-gene expression in Plasmodium falciparum
Creators: name: Wagner, Jeffrey
name: Goldfless, Stephen
name: Ganesan, Suresh
name: Lee, Marcus
name: Fidock, David Armand
name: Niles, Jacquin
Publisher: name: Columbia University
Year: 2013
Subjects: subject: Transgenes--Expression
subject: Malaria--Immunological aspects
subject: Genetics
subject: FOS: Biological sciences
subject: Microbiology

description: Background: The construction of plasmid vectors for transgene expression in the malaria parasite, Plasmodium falciparum, presents major technical hurdles. Traditional molecular cloning by restriction and ligation often yields deletions and re-arrangements when assembling low-complexity (A + T)-rich parasite DNA. Furthermore, the use of large 5′- and 3′- untranslated regions of DNA sequence (UTRs) to drive transgene transcription limits the number of expression cassettes that can be incorporated into plasmid vectors. Methods: To address these challenges, two high fidelity cloning strategies, namely yeast homologous recombination and the Gibson assembly method, were evaluated for constructing P. falciparum vectors. Additionally, some general rules for reliably using the viral 2A-like peptide to express multiple proteins from a single expression cassette while preserving their proper trafficking to various subcellular compartments were assessed. Results: Yeast homologous recombination and Gibson assembly were found to be effective strategies for successfully constructing P. falciparum plasmid vectors. Using these cloning methods, a validated family of expression vectors that provide a flexible starting point for user-specific applications was created. These vectors are also compatible with traditional cloning by restriction and ligation, and contain useful combinations of commonly used features for enhancing plasmid segregation and site-specific integration in P. falciparum. Additionally, application of a 2A-like peptide for the synthesis of multiple proteins from a single expression cassette, and some rules for combinatorially directing proteins to discrete subcellular compartments were established. Conclusions: A set of freely available, sequence-verified and functionally validated parts that offer greater flexibility for constructing P. falciparum vectors having expanded expression capacity is provided.
Relativistic jets in narrow-line Seyfert 1 galaxies. New discoveries and open questions
Creators: name: D'Ammando, F.
name: Orienti, M.
name: Finke, J.
name: Larsson, J.
name: Giroletti, M.
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Before the launch of the Fermi satellite only two classes of AGNs were known to produce relativistic jets and thus emit up to the gamma-ray energy range: blazars and radio galaxies, both hosted in giant elliptical galaxies. The first four years of observations by the Large Area Telescope on board Fermi confirmed that these two are the most numerous classes of identified sources in the extragalactic gamma-ray sky, but the discovery of gamma-ray emission from 5 radio-loud narrow-line Seyfert 1 galaxies revealed the presence of a possible emerging third class of AGNs with relativistic jets. Considering that narrow-line Seyfert 1 galaxies seem to be typically hosted in spiral galaxy, this finding poses intriguing questions about the nature of these objects, the onset of production of relativistic jets, and the cosmological evolution of radio-loud AGN. Here, we discuss the radio-to-gamma-rays properties of the gamma-ray emitting narrow-line Seyfert 1 galaxies, also in comparison with the blazar scenario.
description: 6 pages, 2 Tables. Proceedings of the meeting "The Innermost Regions of Relativistic Jets and Their Magnetic Fields", Granada, Spain
Identification of broadly neutralizing antibody epitopes in the HIV-1 envelope glycoprotein using evolutionary models
Creators: name: Lacerda, Miguel
name: Moore, Penny
name: Ngandu, Nobubelo
name: Seaman, Michael
name: Gray, Elin
name: Murrell, Ben
name: Krishnamoorthy, Mohan
name: Nonyane, Molati
name: Madiga, Maphuti
name: Wibmer, Constantinos
name: Sheward, Daniel
name: Bailer, Robert
name: Gao, Hongmei
name: Greene, Kelli
name: Karim, Salim S Abdool
name: Mascola, John
name: Korber, Bette
name: Montefiori, David
name: Morris, Lynn
name: Williamson, Carolyn
name: Seoighe, Cathal
Publisher: name: Columbia University
Year: 2013
Subjects: HIV (Viruses)
Virology
Epidemiology

description: Background: Identification of the epitopes targeted by antibodies that can neutralize diverse HIV-1 strains can provide important clues for the design of a preventative vaccine. Methods: We have developed a computational approach that can identify key amino acids within the HIV-1 envelope glycoprotein that influence sensitivity to broadly cross-neutralizing antibodies. Given a sequence alignment and neutralization titers for a panel of viruses, the method works by fitting a phylogenetic model that allows the amino acid frequencies at each site to depend on neutralization sensitivities. Sites at which viral evolution influences neutralization sensitivity were identified using Bayes factors (BFs) to compare the fit of this model to that of a null model in which sequences evolved independently of antibody sensitivity. Conformational epitopes were identified with a Metropolis algorithm that searched for a cluster of sites with large Bayes factors on the tertiary structure of the viral envelope. Results: We applied our method to ID50 neutralization data generated from seven HIV-1 subtype C serum samples with neutralization breadth that had been tested against a multi-clade panel of 225 pseudoviruses for which envelope sequences were also available. For each sample, between two and four sites were identified that were strongly associated with neutralization sensitivity (2ln(BF) > 6), a subset of which were experimentally confirmed using site-directed mutagenesis. Conclusions: Our results provide strong support for the use of evolutionary models applied to cross-sectional viral neutralization data to identify the epitopes of serum antibodies that confer neutralization breadth.
Vários, Secolarizazione e sacerdozio. Atti del IV convegno di Teologia pastorale organizzato dalla revista «Studi Cattolici». Ed. ARES. Vol. de 211 ps. 115x220. Mllano 1970
Creators: name: Arieiro, José
Publisher: name: Theologica
Year: 1970

description: Theologica, v. 5 n. 4 (1970)
Generation of iPSC lines from archived non-cryoprotected biobanked dura mater
Creators: name: Sproul, Andrew
name: Vensand, Lauren
name: Dusenberry, Carmen
name: Jacob, Samson
name: Vonsattel, Jean Paul
name: Paull, Daniel
name: Shelanski, Michael L.
name: Crary, John F.
name: Noggle, Scott
Publisher: name: Columbia University
Year: 2014
Subjects: subject: Neural stem cells
subject: Neurosciences
subject: FOS: Clinical medicine
subject: Pathology

description: Background: Induced pluripotent stem cells (iPSCs) derived from patients with neurodegenerative disease generally lack neuropathological confirmation, the gold standard for disease classification and grading of severity. The use of tissue with a definitive neuropathological diagnosis would be an ideal source for iPSCs. The challenge to this approach is that the majority of biobanked brain tissue was not meant for growing live cells, and thus was not frozen in the presence of cryoprotectants such as DMSO. Results: We report the generation of iPSCs from frozen non-cryoprotected dural tissue stored at −80°C for up to 11 years. This autopsy cohort included subjects with Alzheimer’s disease and four other neurodegenerative diseases. Conclusions: Disease-specific iPSCs can be generated from readily available, archival biobanked tissue. This allows for rapid expansion of generating iPSCs with confirmed pathology as well as allowing access to rare patient variants that have been banked.