title: Ð¢ÐµÐ¾ÑÐ¸Ñ ÑÐ°Ð¼Ð¾Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¼Ð°ÐºÑÐ¾Ð¼Ð¾Ð»ÐµÐºÑÐ» ÑÐ»Ð¾Ð¶Ð½Ð¾Ð¹ Ð°ÑÑ Ð¸ÑÐµÐºÑÑÑÑ Ð² ÑÐ°ÑÑÐ²Ð¾ÑÐ°Ñ
title: Ð½Ð°ÑÑÐ½ÑÐ¹ Ð´Ð¾ÐºÐ»Ð°Ð´
titleType: Subtitle
title: Theory of self-organization of macromolecules of complex architecture in solutions
Creators: name: ÐÐµÐ±ÐµÐ´ÐµÐ²Ð°, ÐÐ½Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2019
Subjects: ÑÐ°Ð¼Ð¾Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð°ÑÐ¸Ñ Ð¼Ð¸ÑÐµÐ»Ð»
Ð¼Ð¸ÑÐµÐ»Ð»Ñ
Ð¼Ð¸ÑÐµÐ»Ð»Ð¾Ð¾Ð±ÑÐ°Ð·Ð¾Ð²Ð°Ð½Ð¸Ðµ
Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ½ÑÐµ ÑÐµÑÐºÐ¸
Ð°Ð¼ÑÐ¸ÑÐ¸Ð»ÑÐ½ÑÐµ Ð¼Ð°ÐºÑÐ¾Ð¼Ð¾Ð»ÐµÐºÑÐ»Ñ
Ð±Ð»Ð¾Ðº-ÑÐ¾Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÑ
self-assembly of micelles
micelles
micelle forming
polymer brushes
amphphilic macromolecules
block-copolymers

description: ÐÐ¾ÑÐ»ÐµÐ´Ð½Ð¸Ðµ Ð½ÐµÑÐºÐ¾Ð»ÑÐºÐ¾ Ð´ÐµÑÑÑÐ¸Ð»ÐµÑÐ¸Ð¹ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ðµ Ð½Ð°Ð½Ð¾ÑÐ°Ð·Ð¼ÐµÑÐ½ÑÑ ÑÐ°Ð¼Ð¾Ð¾ÑÐ³Ð°Ð½Ð¸Ð·Ð¾Ð²Ð°Ð½Ð½ÑÑ Ð¼Ð¸ÑÐµÐ»Ð» Ð² Ð´Ð¾ÑÑÐ°Ð²ÐºÐµ Ð»ÐµÐºÐ°ÑÑÑÐ² Ð¸ Ð³ÐµÐ½Ð½Ð¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸ ÑÑÐ°Ð»Ð¾ Ð¿Ð¾Ð¿ÑÐ»ÑÑÐ½Ð¾Ð¹ Ð¿Ð°ÑÐ°Ð´Ð¸Ð³Ð¼Ð¾Ð¹, Ð¾ÑÐ¾Ð±ÐµÐ½Ð½Ð¾ Ð² Ð¾Ð±Ð»Ð°ÑÑÐ¸ Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾ÑÐ°ÐºÐ¾Ð²Ð¾Ð¹ ÑÐµÑÐ°Ð¿Ð¸Ð¸. ÐÐ¸ÑÐµÐ»Ð»Ñ Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð»ÑÑÑ ÐºÑÐ°Ð¹Ð½Ðµ Ð¸Ð½ÑÐµÑÐµÑÐ½ÑÐ¹ Ð¾Ð±ÑÐµÐºÑ Ð´Ð»Ñ ÑÐµÑÐµÐ½Ð¸Ñ Ð¿Ð¾Ð´Ð¾Ð±Ð½ÑÑ Ð·Ð°Ð´Ð°Ñ Ð² ÑÐ¸Ð»Ñ Ð¸Ñ ÑÐ°Ð·Ð¼ÐµÑÐ°, ÑÑÐ°Ð±Ð¸Ð»ÑÐ½Ð¾ÑÑÐ¸ Ð¸ Ð½Ð°Ð³ÑÑÐ·Ð¾ÑÐ½Ð¾Ð¹ ÐµÐ¼ÐºÐ¾ÑÑÐ¸, ÐºÐ¾ÑÐ¾ÑÑÐµ Ð¼Ð¾Ð³ÑÑ Ð±ÑÑÑ Ð¾ÑÐµÐ½Ñ ÑÐ¾Ð½ÐºÐ¾ Ð¾ÑÑÐµÐ³ÑÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ñ Ð¿ÑÑÐµÐ¼ Ð¿ÑÐ°Ð²Ð¸Ð»ÑÐ½Ð¾Ð³Ð¾ Ð¿Ð¾Ð´Ð±Ð¾ÑÐ° ÑÐ¾ÑÑÐ°Ð²Ð»ÑÑÑÐ¸Ñ Ð¸Ñ Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ¾Ð². ÐÐ°Ð¶Ð´Ð°Ñ Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ½Ð°Ñ Ð¼Ð¸ÑÐµÐ»Ð»Ð° ÑÐ¾Ð´ÐµÑÐ¶Ð¸Ñ Ð³Ð¸Ð´ÑÐ¾ÑÐ¾Ð±Ð½Ð¾Ðµ ÑÐ´ÑÐ¾, Ð² ÐºÐ¾ÑÐ¾ÑÐ¾Ð¼ Ð¼Ð¾Ð³ÑÑ Ð´ÐµÐ¿Ð¾Ð½Ð¸ÑÐ¾Ð²Ð°ÑÑÑÑ Ð³Ð¸Ð´ÑÐ¾ÑÐ¾Ð±Ð½ÑÐµ Ð»ÐµÐºÐ°ÑÑÑÐ²ÐµÐ½Ð½ÑÐµ ÑÑÐµÐ´ÑÑÐ²Ð°, Ð¸ Ð³Ð¸Ð´ÑÐ¾ÑÐ¸Ð»ÑÐ½ÑÑ ÐºÐ¾ÑÐ¾Ð½Ñ, ÐºÐ¾ÑÐ¾ÑÐ°Ñ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÑÐµÑ ÑÐ°ÑÑÐ²Ð¾ÑÐ¸Ð¼Ð¾ÑÑÑ Ð°Ð³ÑÐµÐ³Ð°ÑÐ° Ð² Ð²Ð¾Ð´Ðµ, Ð¾Ð±ÐµÑÐ¿ÐµÑÐ¸Ð²Ð°ÐµÑ ÐµÐ³Ð¾ Ð¿ÑÐ¾Ð½Ð¸ÐºÐ°ÑÑÑÑ ÑÐ¿Ð¾ÑÐ¾Ð±Ð½Ð¾ÑÑÑ Ð¸ Ð·Ð°Ð´Ð°ÐµÑ Ð¾Ð±ÑÐ¸Ð¹ ÑÐ°Ð·Ð¼ÐµÑ. ÐÐ½ ÑÐµÐ³ÑÐ»Ð¸ÑÑÐµÑ Ð¸Ñ Ð¿ÑÐ¾Ð½Ð¸ÐºÐ°ÑÑÑÑ ÑÐ¿Ð¾ÑÐ¾Ð±Ð½Ð¾ÑÑÑ Ð¸ Ð¾Ð±ÐµÑÐ¿ÐµÑÐ¸Ð²Ð°ÐµÑ ÑÑÑÐµÐºÑÐ¸Ð²Ð½ÑÑ Ð´Ð¾ÑÑÐ°Ð²ÐºÑ Ð² ÑÐºÐ°Ð½Ð¸-Ð¼Ð¸ÑÐµÐ½Ð¸.
 Ð¤ÑÐ½ÐºÑÐ¸Ð¾Ð½Ð°Ð»Ð¸Ð·Ð°ÑÐ¸Ñ Ð³Ð¸Ð´ÑÐ¾ÑÐ¸Ð»ÑÐ½ÑÑ Ð±Ð»Ð¾ÐºÐ¾Ð² Ð² ÐºÐ¾ÑÐ¾Ð½Ðµ Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ Ð»Ð¸Ð³Ð°Ð½Ð´Ð¾Ð² Ð¿Ð¾Ð·Ð²Ð¾Ð»ÑÐµÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°ÑÑ Ð¼ÐµÑÐ°Ð½Ð¸Ð·Ð¼Ñ Ð±Ð¸Ð¾ÑÐ°ÑÐ¿Ð¾Ð·Ð½Ð°Ð½Ð¸Ñ. Ð¡Ð»ÐµÐ´Ð¾Ð²Ð°ÑÐµÐ»ÑÐ½Ð¾, Ð·Ð°Ð¼ÐµÐ½Ð° Ð»Ð¸Ð½ÐµÐ¹Ð½ÑÑ Ð±Ð»Ð¾Ðº-ÑÐ¾Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ¾Ð² Ð»Ð¸Ð½ÐµÐ¹Ð½Ð¾-Ð´ÐµÐ½Ð´ÑÐ¸ÑÐ½ÑÐ¼Ð¸ Ð¼Ð°ÐºÑÐ¾Ð¼Ð¾Ð»ÐµÐºÑÐ»Ð°Ð¼Ð¸, Ð²ÐºÐ»ÑÑÐ°ÑÑÐ¸Ð¼Ð¸ ÑÐ°ÑÑÐ²Ð¾ÑÐ¸Ð¼ÑÐ¹ Ð´ÐµÐ½Ð´ÑÐ¸ÑÐ½ÑÐ¹ Ð±Ð»Ð¾Ðº, Ð¿Ð¾Ð·Ð²Ð¾Ð»Ð¸Ñ ÑÐ²ÐµÐ»Ð¸ÑÐ¸ÑÑ ÐºÐ¾Ð»Ð¸ÑÐµÑÑÐ²Ð¾ Ð¿Ð¾ÑÐµÐ½ÑÐ¸Ð°Ð»ÑÐ½Ð¾ ÑÑÐ½ÐºÑÐ¸Ð¾Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÑÐµÐ¼ÑÑ Ð³ÑÑÐ¿Ð¿ Ð¿ÑÐ¸ ÑÐ¾ÑÑÐ°Ð½ÐµÐ½Ð¸Ð¸ ÑÐ°Ð·Ð¼ÐµÑÐ° Ð¼Ð¸ÑÐµÐ»Ð»Ñ Ð² Ð·Ð°Ð´Ð°Ð½Ð½ÑÑ Ð¿ÑÐµÐ´ÐµÐ»Ð°Ñ.
Ð¤ÑÐ½ÐºÑÐ¸Ð¾Ð½Ð°Ð»Ð¸Ð·Ð°ÑÐ¸Ñ Ð¾Ð±Ð¾Ð¸Ñ Ð±Ð»Ð¾ÐºÐ¾Ð², A Ð¸ B, Ð¼Ð¾Ð¶ÐµÑ ÑÐ¼ÐµÑÑÐ¸ÑÑ Ð³ÑÐ°Ð½Ð¸ÑÑ Ð¼ÐµÐ¶Ð´Ñ Ð´Ð¸Ð°Ð¿Ð°Ð·Ð¾Ð½Ð°Ð¼Ð¸ ÑÑÐ°Ð±Ð¸Ð»ÑÐ½Ð¾ÑÑÐ¸ ÑÑÐµÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¼Ð¸ÑÐµÐ»Ð» Ð¸ Ð½ÐµÑÑÐµÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð°Ð³ÑÐµÐ³Ð°ÑÐ¾Ð² (ÑÐ¸Ð»Ð¸Ð½Ð´ÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð¼Ð¸ÑÐµÐ»Ð», Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ¾ÑÐ¾Ð¼) Ð¿Ð¾ ÑÑÐ°Ð²Ð½ÐµÐ½Ð¸Ñ Ñ ÑÐ°ÐºÐ¾Ð²Ð¾Ð¹ Ð´Ð»Ñ Ð³Ð¾Ð¼Ð¾Ð»Ð¾Ð³Ð¸ÑÐ½Ð¾Ð³Ð¾ Ð»Ð¸Ð½ÐµÐ¹Ð½Ð¾Ð³Ð¾ Ð±Ð»Ð¾Ðº-ÑÐ¾Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ°. ÐÐ´Ð½Ð°ÐºÐ¾ Ð¸Ð·-Ð·Ð° Ð½ÐµÐ·Ð½Ð°ÑÐ¸ÑÐµÐ»ÑÐ½Ð¾Ð³Ð¾ ÑÐ¿ÑÑÐ³Ð¾Ð³Ð¾ Ð²ÐºÐ»Ð°Ð´Ð° Ð² ÑÐ²Ð¾Ð±Ð¾Ð´Ð½ÑÑ ÑÐ½ÐµÑÐ³Ð¸Ñ Ð±Ð»Ð¾ÐºÐ¾Ð² ÑÐ´ÑÐ° Ð² Ð¾Ð±Ð»Ð°ÑÑÐ¸ ÑÑÐ°Ð±Ð¸Ð»ÑÐ½Ð¾ÑÑÐ¸ ÑÑÐµÑÐ¸ÑÐµÑÐºÐ¸Ñ Ð°Ð³ÑÐµÐ³Ð°ÑÐ¾Ð² Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ ÑÐ°Ð·Ð²ÐµÑÐ²Ð»ÐµÐ½Ð¸Ñ Ð±Ð»Ð¾ÐºÐ° B Ð½Ð° Ð¿Ð°ÑÐ°Ð¼ÐµÑÑÑ ÑÑÐµÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð¼Ð¸ÑÐµÐ»Ð»Ñ Ñ Ð´ÐµÐ½Ð´ÑÐ¾Ð½Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð¹ ÐºÐ¾ÑÐ¾Ð½Ð¾Ð¹ Ð±ÑÐ´ÐµÑ Ð½ÐµÐ·Ð½Ð°ÑÐ¸ÑÐµÐ»ÑÐ½ÑÐ¼. ÐÐ¾Ð»ÐµÐµ Ð¿Ð¾Ð´ÑÐ¾Ð±Ð½ÑÐ¹ Ð°Ð½Ð°Ð»Ð¸Ð· Ð¼Ð¾ÑÑÐ¾Ð»Ð¾Ð³Ð¸Ð¹ Ð¼Ð¸ÑÐµÐ»Ð» Ð¸ Ð¸Ñ Ð´Ð¸Ð°Ð¿Ð°Ð·Ð¾Ð½Ð¾Ð² ÑÑÐ°Ð±Ð¸Ð»ÑÐ½Ð¾ÑÑÐ¸ Ð±ÑÐ´ÐµÑ Ð²ÑÐ¿Ð¾Ð»Ð½ÐµÐ½ Ð² Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÐµ Ð½Ð° ÑÐ¾Ð¸ÑÐºÐ°Ð½Ð¸Ðµ ÑÑÐµÐ¿ÐµÐ½Ð¸ ÐºÐ°Ð½Ð´Ð¸Ð´Ð°ÑÐ° Ð½Ð°ÑÐº.
description: Over the past few decades, the use of nanoscale self-organized micelles in drug delivery and gene therapy has become a popular paradigm, especially in the field of anticancer therapy. Micelles are extremely important objects for solving these problems. Each polymer micelle contains a hydrophobic core, (that could contains hydrophobic drugs) and a hydrophilic corona can be deposited, which determine the solubility of aggregates in water, which ensures its ability to perceive and determines the overall size. It regulates their ability to penetrate target tissues.
The functionalization of hydrophilic blocks in the corona using ligands allows the use of bio-recognition mechanisms. Therefore, the replacement of linear block copolymers by linear-dendritic macromolecules, including a soluble dendritic block, will increase the number of available functional groups while maintaining the micelle size within specified limits.
Functionalisation of both blocks, A and B, can range between spherical and non-spherical aggregates (direct micelles, polymerosomes) compared to a homologous linear block copolymer. However, the presence of a weak elastic element in all spheres associated with stable spherical aggregates is due to the influence of branched blocks B on the parameters of the dendronized corona, which will be insignificant.