cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Liolaemus chillanensis subsp. chillanensis Muller & Hellmich
Creators: name: Pincheira-Donoso, Daniel
name: Scolaro, J. Alejandro
name: Sura, Piotr
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Liolaemidae
Liolaemus
Liolaemus chillanensis
Liolaemus chillanensis chillanensis müller & hellmich

description: Liolaemus chillanensis chillanensis Müller & Hellmich
Liolaemus monticola chillanensis Müller & Hellmich 1932c: 183 (type locality: Termas de Chillán, 1700 m, Ñuble Province, Bío Bío Region, Chile); Burt & Burt 1933: 34; Hellmich 1934: 92; Donoso-Barros 1966a: 229, 1970a: 186, 1970b: 94; Webb & Greer 1969: 193; Vanzolini 1986: 15; Veloso & Navarro 1988: 507; Laurent 1992: 32; Núñez & Jaksic 1992: 74; Etheridge 1995: 33; Etheridge & Espinoza 2000: 7; Pincheira-Donoso 2003b: 5.
Liolaemus (Liolaemus) chillanensis chillanensis Pincheira-Donoso & Núñez 2005: 252.
Liolaemus chillanensis Núñez 2004: 29.
Liolaemus monticola Schulte et al. 2004: 410 (in part).
L [iolaemus] chillanensis Díaz & Lobo 2006: 265.
description: Published as part of Pincheira-Donoso, Daniel, Scolaro, J. Alejandro & Sura, Piotr, 2008, A monographic catalogue on the systematics and phylogeny of the South American iguanian lizard family Liolaemidae (Squamata, Iguania), pp. 1-85 in Zootaxa 1800 on page 22, DOI: 10.5281/zenodo.6789337
Repression of c-Jun oncogene activity in Lung Cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: It is estimated that lung cancer led to 1.3 million deaths worldwide in 2007, contributing to 15% of all cancer deaths. Smoking is the leading origin of lung cancer worldwide, causing 80% of the disease in men and 50% in women. In the year 2008, there is an anticipated 215,020 new cases of lung cancer in the United States, with 18,060 in California alone, leading to a corresponding 13,100 deaths in the state. Non-small cell lung cancer (NSCLC) contributes to 80% of all lung cancer cases, and tobacco smoking is its leading cause. The development of more effective treatments for NSCLC is therefore greatly needed.

 A signature attribute of NSCLC is the over-expression of the c-jun oncogene, which encodes the c-Jun protein. Analysis of tumor specimens revealed that 31-50% of patients with NSCLC also possessed elevated c-jun expression levels. The c-Jun protein regulates the gene expression of other proteins by combining with another protein (c-Fos) and recognizing specific DNA sequences. When c-Jun is over-expressed, many of these c-Jun-regulated genes also become deregulated and frequently lead to uncontrolled cell cycle progression, a trademark of cancer.

 In our proposed research, we hope to disrupt the c-Jun/c-Fos units from binding to those specific DNA sequences that cause the deregulation of other genes. By blocking this event, we believe that the NSCLC cells will be unable to continue growth and lead to cell death. A small molecule will be designed to bind specifically to these desired DNA sites and literally block them from the protein. This approach does not perturb the production of c-Jun protein, but only aims at disrupting its proto-oncogenic activity. We believe that this is significant because c-Jun also functions via different pathways for normal cellular functions. Our plan is to generate a set of DNA-binding molecules and examine their abilities to disrupt deregulated c-Jun activity, and their potential as anti-cancer reagents. If we should succeed, this research may form the foundation for new human cancer treatment methods.
Squalus Linnaeus 1758
Creators: name: Linnaei, Caroli
Publisher: name: Zenodo
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Amphibia
Nantes
Squalidae
Squalus

description: 115 'SQUALUS.
Spiracula V ad latera colli.
Corpus oblongum teretiusculum.
Os in anteriore capitis parte.
* Dor so spino s o pinna ani nulla.
description: Published as part of Linnaei, Caroli, 1758, Regnum Animale, pp. 1-65 in Systema Naturae 1 on page 233, DOI: 10.5281/zenodo.14648402
Blaesoxipha williamsi Johnson
Creators: name: Sinclair, Bradley J.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Odiniidae
Blaesoxipha
Blaesoxipha williamsi

description: williamsi Johnson
Odinia williamsi Johnson, 1924: 90. Curran 1932: 358 [records]; Curran 1934: 163 [records]; Sabrosky 1959: 232 [review]; Linsley & Usinger 1966: 170 [checklist]; Prado 1975: 1 [catalogue]; Sinclair 2009: 103 [photo]; Gaimari & Mathis 2011: 313 [catalogue].
Distribution. Endemic. Galápagos: Baltra, Floreana, Isabela, Marchena, Pinta, Rábida, Santa Cruz, Santa Fé.
Remarks. Adults of this species were reared from Jasminocereus cactus and found primarily in the arid zone. Odinia williamsi was frequently found swarming around heads of humans and on Santa Fé was observed around the head and eyes of land iguanas.
description: Published as part of Sinclair, Bradley J., 2023, An annotated checklist of the Diptera of the Galápagos Archipelago (Ecuador), pp. 1-102 in Zootaxa 5283 (1) on pages 46-47, DOI: 10.11646/zootaxa.5283.1.1, http://zenodo.org/record/7912667
Liolaemus chillanensis subsp. villaricensis Muller & Hellmich
Creators: name: Pincheira-Donoso, Daniel
name: Scolaro, J. Alejandro
name: Sura, Piotr
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Liolaemidae
Liolaemus
Liolaemus chillanensis
Liolaemus chillanensis villaricensis müller & hellmich

description: Liolaemus chillanensis villaricensis Müller & Hellmich
Liolaemus monticola villaricensis Müller & Hellmich 1932c: 189 (type locality: Villarrica Volcano, La Araucanía Region, Chile); Burt & Burt 1933: 34; Hellmich 1934: 94; Donoso-Barros 1966a: 231, 1970a: 186, 1970b: 94; Vanzolini 1986: 15; Veloso & Navarro 1988: 507; Laurent 1992: 32; Núñez & Jaksic 1992: 74; Etheridge 1995: 33; Etheridge & Espinoza 2000: 7; Pincheira-Donoso 2003b: 5.
Liolaemus (Liolaemus) chillanensis villaricensis Pincheira-Donoso & Núñez 2005: 279 (nomina dubia).
L [iolaemus] villaricensis Díaz & Lobo 2006: 265.
description: Published as part of Pincheira-Donoso, Daniel, Scolaro, J. Alejandro & Sura, Piotr, 2008, A monographic catalogue on the systematics and phylogeny of the South American iguanian lizard family Liolaemidae (Squamata, Iguania), pp. 1-85 in Zootaxa 1800 on page 22, DOI: 10.5281/zenodo.6789337
Miculissima Simon-Pražák, Yamamoto, Lackner, Fikáček, Prokop & Caterino, 2024, gen. nov.
Creators: name: Simon-Pražák, Jan
name: Yamamoto, Shûhei
name: Lackner, Tomáš
name: Fikáček, Martin
name: Prokop, Jakub
name: Caterino, Michael S
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Histeridae
Miculissima

description: Miculissima gen. nov.
Type species. Miculissima excavata sp. nov ..
Diagnosis: Tiny body size, body oval-shaped and glabrous. Frons flat, wide, clypeus convex, labrum short and wide, with a pair of prominent setae laterally. Antennal club round with two distinct annuli. Eyes convex. Pronotum widely angular posteriorly, with complete marginal stria and a lateral pronotal stria. Scutellar shield tiny, triangular. Prosternal hypomeron widely excavate and irregularly structured, with a weakly defined antennal cavity. Prosternum with fissures for antennal passage. Prosternal process short, without prosternal lobe, slightly emarginate posteriorly. Tibiae simple, slightly widened, with several spines.
Etymology: Feminine, derived from the Latin noun ‘mica’ which translates as crumb, grain or morsel.
description: Published as part of Simon-Pražák, Jan, Yamamoto, Shûhei, Lackner, Tomáš, Fikáček, Martin, Prokop, Jakub & Caterino, Michael S, 2024, A bonanza of Cretaceous fossils provides insights into the evolution of antennal protection in clown beetles (Coleoptera: Histeridae), pp. 1-28 in Zoological Journal of the Linnean Society (zlae 137) (zlae 137) 202 (3) on page 20, DOI: 10.1093/zoolinnean/zlae137, http://zenodo.org/record/14516114
Pagurus marysolae Lemaitre, 2022, sp. nov.
Creators: name: Hendrickx Rafael Lemaitre, Manuel Ayón Parente Michel E.
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda
Paguridae
Pagurus
Pagurus marysolae

description: Pagurus marysolae sp. nov.
(Figs. 5A–H, 6A–E)
description: Published as part of Hendrickx Rafael Lemaitre, Manuel Ayón Parente Michel E., 2022, Generic reassignment and redescription of Pagurus gladius (Benedict, 1892), and description of a new species of Pagurus Fabricius, 1775 (Crustacea: Paguroidea: Paguridae) from the Mexican Pacific, pp. 1-16 in Nauplius (e 2022039) (e 2022039) 30 on page 10, DOI: 10.1590/2358-2936e2022039, http://zenodo.org/record/14667078
Macropisthodon flaviceps Dumeril, Bibron & Dumeril 1854
Creators: name: Teynié, Alexandre
name: David, Patrick
name: Ohler, Annemarie
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Colubridae
Macropisthodon
Macropisthodon flaviceps

description: Macropisthodon flaviceps (Duméril, Bibron & Duméril, 1854) *
Material examined. Two specimens (1 adult and 1 subadult) examined alive and photographed, in the vicinity North of Bangko, Province of Jambi.
Taxonomic comments. Two typical specimens as depicted in Chan-Ard et al. (1999) and Stuebing & Inger (1999).
Distribution on Sumatra. Provinces of Jambi (first record in this work), and Aceh, Sumatera Utara, Riau, Bengkulu, Sumatera Selatan, and Lampung; also the islands of Bangka and Nias (David & Vogel, 1996).
Biology. These specimens were found in the morning in a lowland marsh in November.
description: Published as part of Teynié, Alexandre, David, Patrick & Ohler, Annemarie, 2010, Note on a collection of Amphibians and Reptiles from Western Sumatra (Indonesia), with the description of a new species of the genus Bufo, pp. 1-43 in Zootaxa 2416 on pages 23-24, DOI: 10.5281/zenodo.194395
Xenochrophis trianguligerus Boie 1827
Creators: name: Teynié, Alexandre
name: David, Patrick
name: Ohler, Annemarie
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Colubridae
Xenochrophis
Xenochrophis trianguligerus

description: Xenochrophis trianguligerus (Boie, 1827)
(Fig. 6 f)
Material examined. 3 specimens examined alive and photographed, from Maninjau, Mukomuko and Bayur respectively, Province of Sumatera Barat, elev. 480– 500 m.
Taxonomic comments. These specimens as typical for this species as depicted in Chan-Ard et al. (1999).
Distribution on Sumatra. Provinces of Aceh, Sumatera Utara, Sumatera Barat, Riau, Jambi, Bengkulu, Sumatera Selatan, and Lampung (David & Vogel, 1996); also the islands of Bangka, Belitung and Nias, and Riau Archipelago.
Biology. The specimen from Maninjau was observed near human dwellings, whereas the specimen from Mukomuko was found dead on a road edging an area of forest and cultures. Lastly, the specimen from Bayur was obtained in a rice field in the end of the afternoon.
description: Published as part of Teynié, Alexandre, David, Patrick & Ohler, Annemarie, 2010, Note on a collection of Amphibians and Reptiles from Western Sumatra (Indonesia), with the description of a new species of the genus Bufo, pp. 1-43 in Zootaxa 2416 on page 24, DOI: 10.5281/zenodo.194395
Liolaemus coeruleus Cei & Ortiz (Pincheira-Donoso & Scolaro 2007
Creators: name: Pincheira-Donoso, Daniel
name: Scolaro, J. Alejandro
name: Sura, Piotr
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Liolaemidae
Liolaemus
Liolaemus coeruleus

description: Liolaemus coeruleus Cei & Ortiz
Liolaemus coeruleus Cei & Ortiz 1983: 35 (type locality: 10 km W Primero Pinos, 1700 m, Zapala, Neuquén Province, Argentina); Cei 1986: 249; Vanzolini 1986: 13; Brygoo 1989: 29; Laurent 1992: 31; Bertonatti 1994: 169; Etheridge 1995: 33; Videla & Cei 1998: 63; Etheridge & Espinoza 2000: 5; Schulte et al. 2000: 78; Lobo 2001: 139; Cei & Videla 2003a: 278; Chebez et al. 2005: 30; Sura 2005: 428; Díaz & Lobo 2006: 264; Scolaro 2006: 31; PincheiraDonoso & Scolaro 2007: 57.
Liolaemus (Liolaemus) coeruleus Pincheira-Donoso & Núñez 2005: 303.
description: Published as part of Pincheira-Donoso, Daniel, Scolaro, J. Alejandro & Sura, Piotr, 2008, A monographic catalogue on the systematics and phylogeny of the South American iguanian lizard family Liolaemidae (Squamata, Iguania), pp. 1-85 in Zootaxa 1800 on page 22, DOI: 10.5281/zenodo.6789337
Calycomyza lantanae
Creators: name: Sinclair, Bradley J.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Agromyzidae
Calycomyza
Calycomyza lantanae

description: lantanae (Frick)
Phytobia lantanae Frick, 1956: 287.
Calycomyza lantanae: Causton et al. 2006: 133 [introduced species]; Sasakawa 2007: 194 [review]; Causton & Sevilla 2007: 145 [introduced species].
Distribution. Introduced. Neotropical; Galápagos: Floreana, Genovesa, Isabela, Santa Cruz.
Remarks. Adults of this species were collected in the arid and transition zones. The species is a leaf miner of Lantana camara L. (Spencer & Steyskal 1986).
description: Published as part of Sinclair, Bradley J., 2023, An annotated checklist of the Diptera of the Galápagos Archipelago (Ecuador), pp. 1-102 in Zootaxa 5283 (1) on page 47, DOI: 10.11646/zootaxa.5283.1.1, http://zenodo.org/record/7912667
Histone Deacetylation and Anti-inflammatory Response of GR
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Chronic Obstructive Pulmonary Disease (COPD) is the fourth leading cause of death in the United States, claiming 126,005 American lives in the year of 2005. More than 12 millions of people are currently diagnosed with COPD, with possibly an additional 12 millions of people having the disease without knowing it. COPD is a general term which includes two conditions: chronic bronchitis, persistent inflammation of the airways of the lung, and emphysema, damage to the smaller airways and airsacs of the lungs. Chronic bronchitis or emphysema can cause narrowing of the airways, resulting in breathing difficulty. Tobacco smoking is the cause in the vast majority of COPD cases, as the lining of the airways becomes inflamed and damaged by smoking. People who have never smoked rarely develop COPD. Currently, there is no treatment that can reverse the damage to the airways, thus no known cure of COPD. Because inflammation plays a vital role in the development and progression of COPD, reducing inflammation in lung is an effective approach. Glucocorticoids, a.k.a. corticosteroids, are often included as part of the treatment for COPD patients due to its ability to suppress inflammation. However, long-term glucocorticoids treatment could cause side effects such as osteoporosis, muscle atrophy, and various metabolic disorders. In addition, glucocorticoids¡¦ anti-inflammatory efficacy is greatly reduced in COPD patients comparing its effectiveness seen in other diseases, such as asthma and arthritis. Glucocorticoids convey their signals through a protein that is localized inside the cells called glucocorticoid receptor (GR). It is believed that GR suppresses inflammation by turning off inflammatory genes and, at higher dose, turning on anti-inflammatory genes. Inflammatory genes are turned on by a protein called necrosis factor-kappa B (NF-£eB). Studies have suggested that GR can counteract the inflammatory effect of NF-£eB through recruitment of another protein, histone deacetylase-2 (HDAC2). However, the detailed mechanism of this process is unknown. In this proposal, I will investigate how GR recruits HDAC2 to inhibit NF-£eB action. I will also examine the entire human genome to learn whether HDAC2 is generally required for GR to inhibit NF-£eB-regulated genes, or this mechanism is only for specific subset of NF-£eB-regulated genes. Overall, it is important to explore the mechanism of glucocorticoids¡¦ anti-inflammatory action, as it could reveal new therapeutic target, as well as improve drug designing. In addition, recent studies have shown that HDAC2 level is reduced in COPD patients, which could explain the glucocorticoid resistant phenotype found in COPD patients. My proposed study of GR and HDAC2 connection will shed new light onto this critical issue, and shall specifically benefit the future therapeutic development for COPD.
Asthenodipsas laevis Boie 1837
Creators: name: Teynié, Alexandre
name: David, Patrick
name: Ohler, Annemarie
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Pareatidae
Asthenodipsas
Asthenodipsas laevis

description: Asthenodipsas laevis (Boie, 1837)
Material examined. MNHN 2002.0434 (male; SVL 250 mm, TaL 57 mm), vicinity of Lubuksao, Sumatera Barat Province, elev. 400 m.
Taxonomic comments. This specimen is typical for the species.
Scalation: specimens MNHN 2002.0434: DSR 15-15-13; VEN 159; SC 46.
Distribution on Sumatra. Provinces of Aceh, Sumatera Utara, Sumatera Barat, Riau, Bengkulu, and Sumatera Selatan; also the island of Bangka and Mentawai Archipelago (David & Vogel, 1996).
Biology. This specimen was collected at night around 1930 hours during a rain shower in November, in a rocky primary rainforest near a stream.
description: Published as part of Teynié, Alexandre, David, Patrick & Ohler, Annemarie, 2010, Note on a collection of Amphibians and Reptiles from Western Sumatra (Indonesia), with the description of a new species of the genus Bufo, pp. 1-43 in Zootaxa 2416 on page 24, DOI: 10.5281/zenodo.194395
Cellular Analysis of BAVM Regression in a Mouse Model
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Smoking has been shown to greatly increase the chances of hemorrhagic stroke. Vascular abnormalities, primarily Brain Arteriovenous Malformations (BAVMs), are responsible for half of all hemorrhagic stroke in young people. Approximately 600,000 people worldwide harbor BAVMs that can potentially rupture, leading to stroke and death. The disease is poorly understood, and while surgical treatment can be effective, many BAVMs are inaccessible.

 We recently reported a transgenic mouse model of BAVM-like abnormalities induced by endothelial specific and temporally regulated expression of constitutively-active Notch4 (Notch4*). As in the human disease, arteries and veins were connected through enlarged vessels that bypass the capillary bed. We found that, as in humans, these enlarged arteriovenous connections resulted in the shunting of blood directly from arteries to veins, were prone to hemorrhagic rupture, and resulted in stroke. It is commonly thought that BAVMs do not regress, but rather that they continue to enlarge and eventually rupture. Temporal regulation of Notch4* expression in these mice allows us to test the hypothesis that BAVMs will regress following suppression of the causal stimulus.

 The specific aims of this proposal are to determine whether the hallmarks of BAVM, enlarged arteriovenous connections and high-flow arteriovenous shunting, can be reversed by repression of Notch4*. If true, these findings would suggest that if the stimulus for human BAVM can be blocked, the regression of the vascular abnormalities may occur through latent endogenous pathways. In vivo imaging of the specific endothelial cell (EC) mechanisms underlying this regression will reveal normal endothelial processes that may be promoted to reverse the disease.
Inhibition of ERBB2 expression by polyamides in NSCLC
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cigarette smoke is a major cause of lung cancer, which is the leading form of cancer deaths worldwide. The most common form of clinically treated lung cancer is non-small cell lung cancer. Despite advances in modern medicine, prognosis remains poor for the disease due to high recurrent rates and limited treatment options. Thus, there is an urgent need for the development of new treatments for non-small cell lung cancer (NSCLC).

 A common trait among many forms of cancer, including NSCLC, is the over-abundance of the ERBB2 protein on the cell surface. The ERBB2 protein belongs to a class of signaling receptors known as the epidermal growth factor (EGF) receptors. Together, these proteins regulate cellular differentiation, growth, and migration in normal tissue cells. However, the over production of the ERBB2 protein, which is usually caused by amplification of the ERBB2 gene at the DNA level, triggers uncontrolled cell growth leading to tumor formation and metastasis.

 Instead of blocking the function of the ERBB2 protein like most drugs on the market, we propose a new mechanism of treatment which blocks the production of ERBB2 at the RNA level, thus eliminating the root of the problem. The ERBB2 gene is turned on by two DNA binding transcription factors ETS1 and AP-2. By using a class of programmable sequence-specific DNA-binding molecule known as polyamides we can target the DNA sites where ETS1 and AP-2 regulate the ERBB2 gene and prevent them from turning the gene on. This type of approach is known as anti-transcription factor therapy. Towards this goal, we have designed polyamides to target the ETS1 and AP-2 binding sites, and we have shown these polyamides are able to prevent ETS1 and AP-2 from binding to the ERBB2 gene. Further work will address the ability of the polyamides to turn off the ERBB2 gene in NSCLC cell lines that display an over abundance of ERBB2 protein. Should our experiments prove successful, we hope to establish a polyamide based therapy that can be applied to other forms of cancer.
Squalus acanthias Linnaeus 1758
Creators: name: Linnaei, Caroli
Publisher: name: Zenodo
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Amphibia
Nantes
Squalidae
Squalus
Squalus acanthias

description: Acanthias.
1. S. pinna ani nulla, dorso spinoso, corpore teretiusculo.
Art. gen. 66. syn. 94. spec. 102. Fn. svec. 296. (*) Mu s. Ad. Fr. 1. p. 53. It. Wgot. 174.
Rond. pisc. 373. Galeus acanthias.
Gesn. pisc. 607. Galeus acanthias.
Bellan. pisc. 69. Mustelus spinax.
Salv. pisc. 135. s. 136. Mustelus spinax.
Will. icht. 56. Galeus acanthias s. spınax.
Raj. pisc. 21. Galeus acanthias s. spinax. '
Habitat in Oceano Europaeo.
description: Published as part of Linnaei, Caroli, 1758, Regnum Animale, pp. 1-65 in Systema Naturae 1 on page 233, DOI: 10.5281/zenodo.14648402
Asthenodipsas malaccanus Peters 1864
Creators: name: Teynié, Alexandre
name: David, Patrick
name: Ohler, Annemarie
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Pareatidae
Asthenodipsas
Asthenodipsas malaccanus

description: Asthenodipsas malaccanus (Peters, 1864)
Material examined. MNHN 2002.0435 (female; SVL 373 mm, TaL 45 mm), vicinity East of Pundung Lamanggang, Jambi Province.
Taxonomic comments. This specimen is typical for the species (see, for example, Taylor, 1965).
Scalation: DSR 15-15-15; VEN 167; SC 30; SL 7/7; 2 PreOc.
Distribution on Sumatra.Provinces of Aceh, Sumatera Utara, Sumatera Barat, Riau, Bengkulu, Sumatera Selatan, and Lampung (David & Vogel, 1996; Yves Laumonier, pers. comm., 1998; De Lang, 2003).
Biology. This specimen was discovered in November hidden under a stone at day time in a small garden in a secondary forest.
description: Published as part of Teynié, Alexandre, David, Patrick & Ohler, Annemarie, 2010, Note on a collection of Amphibians and Reptiles from Western Sumatra (Indonesia), with the description of a new species of the genus Bufo, pp. 1-43 in Zootaxa 2416 on page 24, DOI: 10.5281/zenodo.194395
Squalus centrina Linnaeus 1758
Creators: name: Linnaei, Caroli
Publisher: name: Zenodo
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Amphibia
Nantes
Squalidae
Squalus
Squalus centrina

description: Centrina.
2. S. pinna ani nulla, dorso spinoso, corpore sub triangulari. Art. gen. 67. n. 5. syn. 95.
Rond. pisc. 384. Centrina.
Salv. pisc. 156 -158. Centrina.
Gesn. pisc. 609. Centrina.
Will. icht. 58. Centrina.
Raj. pisc. 21. Centrina.
Habitat in Mari Mediterraneo.
. Pinna dor s i anterior spina antrars um radios decussante, posterior retrorsum.
description: Published as part of Linnaei, Caroli, 1758, Regnum Animale, pp. 1-65 in Systema Naturae 1 on page 233, DOI: 10.5281/zenodo.14648402
Xenodermus javanicus Reinhardt 1836
Creators: name: Teynié, Alexandre
name: David, Patrick
name: Ohler, Annemarie
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Xenodermatidae
Xenodermus
Xenodermus javanicus

description: Xenodermus javanicus Reinhardt, 1836 *
(Fig. 7 a,b)
Material examined. 1 specimen photographed (ToL about 60 cm) but not collected, from the vicinity of Lubuksao, Province of Sumatera Barat, elev. ca 400 m.
Taxonomic comments. This specimen is typical for the species as described in De Rooij (1917) and Manthey & Grossmann (1997). Our specimen of this odd-looking and rare species was very thin. Only a few individuals have ever been recorded from Sumatra.
Distribution on Sumatra. Provinces of Sumatera Barat (first record in this work), Aceh, Sumatera Utara and Bengkulu (David & Vogel, 1996; Y. Laumonier, pers. comm., 1998).
Biology. This specimen was collected in August on the bank of a ditch along a road crossing a rocky primary forest near a stream. It was active at about 2000 hours during a heavy rain shower. The snake was not aggressive and the sole defensive posture was a stiffness of its body.
description: Published as part of Teynié, Alexandre, David, Patrick & Ohler, Annemarie, 2010, Note on a collection of Amphibians and Reptiles from Western Sumatra (Indonesia), with the description of a new species of the genus Bufo, pp. 1-43 in Zootaxa 2416 on pages 25-26, DOI: 10.5281/zenodo.194395
Synthesis of Anticancer Peroxides
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Peroxides, a naturally occurring class of compounds that contain an oxygen–oxygen bond, have been shown to be promising drug targets for cancer treatment. More than 120 anticancer peroxides have been discovered, many of which have demonstrated activity against lung cancer and other tobacco-related cancers. Because peroxides occur in nature in only small amounts, natural sources are not likely to be useful sources of medicine. Previous efforts to synthesize peroxides have been difficult due to the weakness of the oxygen–oxygen bond. Our laboratory has demonstrated a new method to synthesize peroxides that could not be synthesized by previous methods. Our research over the next two years will focus on the development of this method to the point where it can be useful for the synthesis of anti-lung cancer peroxides, and its application to the synthesis of both natural and synthetic peroxide variants.
Molecular therapies against small cell lung cancer
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The number one cause of cancer related deaths in the United States is lung cancer. Over 80% of lung cancer cases are due to tobacco. Treatments for lung cancer are limited and there is generally a poor survival rate in patients. Small cell lung cancer (SCLC) is a subtype of lung cancer that comprises about 20% of all lung cancer cases and results in over 200,000 deaths worldwide each year. Most people diagnosed with SCLC have a history of heavy smoking, which strongly correlates tobacco use with this cancer. Unfortunately, SCLC has a very poor prognosis, with a 5-year survival rate of less than 5%.

 Our goal is to gain a better understanding of the molecular mechanisms underlying the development of SCLC. It is our belief that we might be able to use this knowledge to eventually design new and improved treatment options for this deadly cancer. To do this, we will use SCLC tumor cells obtained from a mouse model: in this model, mice are genetically engineered and manipulated to grow lung cancer that is very similar to human SCLC. This genetically defined system is simpler and more amenable to experimental intervention than tumors in human patients, which will enable us to more easily study the biology of these tumor cells.

 Specifically, we propose to re-introduce into these tumor cells lines the two genes, RB and p53, that are most frequently mutated in SCLC. We will determine the effect of re-introducing RB and p53 function on cell growth and survival. Loss of RB and p53 is thought to be an initiating event in SCLC, and we hypothesize that the tumor cells still depend on the loss of function of these two genes to retain their cancer potential. In other words, we hypothesize that re-introducing RB and p53 will stop the tumor cells.

 We also will introduce another gene into SCLC cells: K-Ras is usually found altered in other cancer types but rarely in SCLC, and emerging evidence suggests that K-Ras activity may be detrimental to cells with a mutation in RB, such as SCLC cells. Thus, we hypothesize that introduction of K-Ras in SCLC will be incompatible with the molecular changes that have already happened in SCLC cells (loss of RB and p53), which may result in an arrest in tumor cell growth.

 It is our hope that the resulting knowledge in this mouse system will enable us to identify novel therapeutic targets that can increase treatment options for patients with SCLC.
IL-1b regulation of EMT in NSCLC
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: In the fight against lung cancer, encouraging people to quit smoking is very important, but unfortunately, risk of lung cancer does not vanish when someone quits. Risk of cancer development is highest in current smokers, lower in former smokers and lowest in never smokers. In the first decade after giving up smoking, the risk of lung cancer decreases by 50% over current smokers, yet there is still an increased lung cancer risk for former smokers over never smokers 30 years after quitting.

 Due to constant exposure to tobacco smoke, smokers’ lungs display features of chronic inflammation. Inflammation is usually helpful; it’s part of a healthy body’s response to irritants, injury or illness. Chronic inflammation though, occurs when the body does not shut off its response to these events. During chronic inflammation, many different molecules are overexpressed including tumor necrosis factor-alpha, prostaglandin E2, transforming growth factor-beta and interleukin-1 beta (IL-1beta). This chronic inflammation is a risk factor for the development of lung cancer. However, how these inflammatory molecules affect cancer progression is not known. The focus of this research is on the role of IL-1 beta in inflammation-promoted lung cancer. Studies have shown that the expression of IL-1 beta is increased in a number of cancers, including lung cancer. In patients, the presence of IL-1 is associated with tumor aggressiveness and poor prognosis. We hypothesize that IL-1 beta promotes the progression of lung cancer by induction of epithelial-mesenchymal transition (EMT). EMT is a process whereby epithelial cells which should be stationary and attached to each other no longer make the proteins to allow them to do so. Instead they begin producing proteins normally made by cells that are mobile. Cell adhesion proteins such as E-cadherin show decreased expression while expression of proteins such as N-cadherin and vimentin are increased. When cancer cells lose the ability to attach to each other and gain the ability to move, this sets the stage for cancer to spread or metastasize. Metastasis refers to the spreading of cancer from the organ it began to grow in to other organs in the body.

 Lung cancer is responsible for almost 30% of all cancer deaths with smokers and former smokers accounting for 80-90% of lung cancer cases. Only 15% of patients with lung cancer will survive 5 years after diagnosis. This is a figure that has changed little over the past 25 years and is largely attributed to the fact that lung cancer is most often not diagnosed until metastasis has occurred. In fact most cancer-related deaths are due to metastatic spread. Investigation of the factors involved in promoting metastasis is an important part of identifying new targets for therapies for lung cancer patients and lung cancer prevention.
Calliophis bivirgatus subsp. flaviceps Cantor 1839
Creators: name: Teynié, Alexandre
name: David, Patrick
name: Ohler, Annemarie
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Elapidae
Calliophis
Calliophis bivirgatus
Calliophis bivirgatus flaviceps (cantor, 1839)

description: Calliophis bivirgatus flaviceps (Cantor, 1839)
Material examined. MNHN 2002.0443 (male; SVL 722 mm, TaL 82 mm), Monts Tigapulan, Province of Riau, elev. ca 150 m.
Taxonomic comments. The genus Maticora Gray, 1835 (Type species: Maticora lineata Gray, 1835 by monotypy) was synonymized with Calliophis Gray, 1835 (Type species: Calliophis gracilis Gray, 1835 by monotypy) by Slowinski et al. (2001).
Three subspecies of Calliophis bivirgatus (Boie, 1827) are currently recognized of which only one occurs on Sumatra.
Scalation: DSR 13-13-13, vertebral row not enlarged; VEN 276; SC 46.
Distribution on Sumatra. Provinces of Aceh, Sumatera Utara, Sumatera Barat, Riau, Jambi, Bengkulu, Sumatera Selatan, and Lampung; also the islands of Bangka and Nias, and Mentawai Archipelago and Riau Archipelago (David & Vogel, 1996).
Biology. The sole specimen of this superb species was collected at 2100 hours during a rainy night in November while it was quickly crossing a road in an open forest with a dense layer of tall grasses. This snake did not show any aggressivity when it was collected and tried to bite only in the last resort.
description: Published as part of Teynié, Alexandre, David, Patrick & Ohler, Annemarie, 2010, Note on a collection of Amphibians and Reptiles from Western Sumatra (Indonesia), with the description of a new species of the genus Bufo, pp. 1-43 in Zootaxa 2416 on page 26, DOI: 10.5281/zenodo.194395
Synthesis of Spirolide-Activators of L-type Calcium Channels
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: The American Heart Association has reported that of the 2.4 million annual premature deaths in the United States, smoking and smoking related illnesses account for approximately one-sixth of this astounding number. Cigarette smoking along with high blood pressure (hypertension) are two of the six major factors that contribute to coronary heart disease. Currently, there are several types of therapeutics that are used to treat hypertension which include ACE (angiotension-converting enzyme) inhibitors, ARBs (angiotension receptor blockers), diuretics, beta-blockers, and calcium channel blockers.

 The calcium channel blockers (CCBs) are presumed to work by inhibiting the movement of calcium into the cells of the heart and walls of the blood vessels. As a result, this will widen blood vessels and reduce blood pressure since the heart does not have to work as hard to circulate blood. The L-type calcium channel dominates the activity of the cardiovascular system whereas other calcium channel types contribute little to its mechanical activity. This infers that auxiliary knowledge of channel structure and function may assist in the production of more effective therapeutics.

 CCBs have been an important pharmacological target in the treatment of a number of conditions however they have had controversial success. It is through a comprehensive investigation of known calcium channel activators that will aid in the identification of key binding sites that will optimize the mechanical activity of therapeutic agents.

 The research proposed in this application focuses on the synthesis of the marine natural product spirolide. Marine natural products have long served as leading compounds for new therapeutic agents; however, utilization is often extremely limited due to poor availability. Therefore, exploration of new synthetic techniques offers shortcuts in the production of such agents and the opportunity to discover new applications. A synthetic strategy for the L-type calcium channel activator, 13-desmethyl-spirolide C is described in detail. Understanding the various mechanisms through which calcium channel activation occurs will enable scientists to produce more effective therapeutics to treat hypertension.
Cerodontha dorsalis
Creators: name: Sinclair, Bradley J.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Diptera
Agromyzidae
Cerodontha
Cerodontha dorsalis

description: dorsalis (Loew)
Odontocera dorsalis Loew, 1863: 54.
Cerodontha dorsalis: Curran 1934: 163 [records]; Linsley & Usinger 1966: 171 [checklist]; Boucher 2002: 582 [records]; Sasakawa 2007: 195 [review].
Distribution. Introduced. Nearctic, Neotropical; Galápagos: Fernandina, Floreana, Isabela, Santa Cruz, Santiago.
Remarks. Adults of this species were collected in the humid highlands of Santa Cruz. Larvae feed on numerous species of Poaceae (Spencer 1973).
description: Published as part of Sinclair, Bradley J., 2023, An annotated checklist of the Diptera of the Galápagos Archipelago (Ecuador), pp. 1-102 in Zootaxa 5283 (1) on page 47, DOI: 10.11646/zootaxa.5283.1.1, http://zenodo.org/record/7912667
Squalus spinax Linnaeus 1758
Creators: name: Linnaei, Caroli
Publisher: name: Zenodo
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Amphibia
Nantes
Squalidae
Squalus
Squalus spinax

description: Spinax.
3. S. pinna ani nulla, dorso spinofo, naribus terminalibus. Art. gen. 67. syn. 95.
Will. icht. 57. Galeus acanthias s. spinax fuscus.
Raj. pisc. 21. Galeus acanthias s. spinax fuscus.
Habitat in Europa.
description: Published as part of Linnaei, Caroli, 1758, Regnum Animale, pp. 1-65 in Systema Naturae 1 on page 233, DOI: 10.5281/zenodo.14648402
Liolaemus confusus Nunez & Pincheira-Donoso 2006
Creators: name: Pincheira-Donoso, Daniel
name: Scolaro, J. Alejandro
name: Sura, Piotr
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Liolaemidae
Liolaemus
Liolaemus confusus

description: Liolaemus confusus Núñez & Pincheira-Donoso
Liolaemus confusus Núñez & Pincheira-Donoso 2006: 77 (Type locality: Cerro Los Robles, Lolol, Libertador Bernardo O’Higgins Region, Chile).
description: Published as part of Pincheira-Donoso, Daniel, Scolaro, J. Alejandro & Sura, Piotr, 2008, A monographic catalogue on the systematics and phylogeny of the South American iguanian lizard family Liolaemidae (Squamata, Iguania), pp. 1-85 in Zootaxa 1800 on page 22, DOI: 10.5281/zenodo.6789337
Additional file 3: of Soluble CD40L is associated with increased oxidative burst and neutrophil extracellular trap release in Behçet’s disease
Creators: name: Perazzio, Sandro
name: Soeiro-Pereira, Paulo
name: Santos, Viviane Dos
name: Brito, Marlon De
name: Salu, Bruno
name: Oliva, Maria
name: Stevens, Anne
name: Souza, Alexandre De
name: Ochs, Hans
name: Torgerson, Troy
name: Condino-Neto, Antonio
name: Andrade, Luis
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Marine Biology
subject: Virology
subject: Computational Biology

description: Figure S1. CD40L expression is similar on monocytes and CD8+ T cells from patients with Behçet’s disease. Percentages of CD8+CD40L+ T cells (a) and CD40L+ monocytes (b) were determined under basal conditions and after 3-h stimulation with 1.5 μM ionomycin and/or 25 ng/ml PMA by flow cytometry in healthy control subjects (HC), patients with inactive Behçet’s disease (iBD), and patients with active Behçet’s disease (aBD). No difference in CD40L+ surface expression was observed. (PDF 200 kb)
Squalus aquatina Linnaeus 1758
Creators: name: Linnaei, Caroli
Publisher: name: Zenodo
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Amphibia
Nantes
Squalidae
Squalus
Squalus aquatina

description: Squatina.
4. S. pinna ani nulla, ore terminali. Art. gen. 67. n. 6. syn. 9 5.
Bellon. pisc. 78. Squatina.
Rondel. pisc. 367. Squatina.
(*) lege: 269. Vide Emendanda pag. 824.
Gesn. pisc. 899. Squatina.
Will. icht. 79. Squatina.
Raj. pisc. 26. Squatina.
Habitat in Oceano Europaeo.
Media inter Sgualos & Rajas, ore in apice capitis, ¡MC subtus.
* i * Dorso mutico, dentibus acutis, cum pinna ani.
description: Published as part of Linnaei, Caroli, 1758, Regnum Animale, pp. 1-65 in Systema Naturae 1 on pages 233-234, DOI: 10.5281/zenodo.14648402
title: Artificial leaf surfaces as surrogates to study microbial phyllosphere colonization
Creators: name: Bernach, Michal
Publisher: name: University of Canterbury
Year: 2023

description: The phyllosphere comprises all above ground surfaces of plants. Leaves are dominating this habitat. Leaf surfaces feature diverse microenvironments for microbial colonizers, among which bacteria are the most prominent. The spatial and temporal variability of leaves heavily impacts its colonizers, modulating plant-microbe and microbe- microbe interactions. To study individual factors shaping this environment, it is considered advantageous to deconstruct plant leaf surfaces into their individual aspects with surrogate surfaces proposed to aid in this. The aim of this thesis was thus to develop biomimetic leaf replicas of Arabidopsis thaliana incorporating properties such as leaf topography or hydrophobicity, while allowing for survival of microbial colonizers on the surface in the absence of a living plant host. As a first step to create a biomimetic leaf surface, relevant properties of a selection of polymers - agarose, polydimethylsiloxane (PDMS) and gelatin were characterized. The chosen parameters aimed towards replicating key features of the leaf surface - topography, hydrophobicity, establishing a timeframe for potential experimentation and assessment of materials influence on bacterial colonizers. Based on this analysis, PDMS was determined to be the most suitable material for the fabrication of biomimetic leaf replicas for use in phyllosphere microbiology. Next, PDMS-based membranes were optimized to enable the diffusion of water and nutrients to the surface in order to sustain microbial life. The decrease of material thickness and addition of filler polymers to produce hybrid PDMS membranes (Carbopol, Pemulen, cellulose or polyvinylpyrrolidone) increased water permeability of PDMS, mostly without affecting the ability of PDMS to mimic leaf surface topography and its hydrophobicity. Furthermore, (hybrid-)PDMS membranes were found to be permeable to fructose. This demonstrates the possibility of delivering nutrients to biomimetic leaf surfaces in comparable degrees as to live leaf surfaces. Fructose delivered through the membranes also affected divisions of bacteria on the surface of flat PDMS and their distribution over time. Finally, all the characteristics investigated and developed were combined to fabricate PDMS leaf replica membranes. These biomimetic surfaces constitute the first reported example of surrogates which allow for survival of bacteria on topographically heterogenous and hydrophobic substrates mimicking plant leaves. Additionally, 3D models of leaf topography were developed to enable fabrication of PDMS leaf replica membranes with identical surface features. Such leaf replicas would enable higher comparability and transferability of experimental work. In conclusion, the biomimetic surfaces developed as part of this thesis represent an important platform technology for the phyllosphere microbiology toolbox.
Calliophis intestinalis subsp. lineatus Gray 1835
Creators: name: Teynié, Alexandre
name: David, Patrick
name: Ohler, Annemarie
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Reptilia
Squamata
Elapidae
Calliophis
Calliophis intestinalis
Calliophis intestinalis lineatus (gray, 1835)

description: Calliophis intestinalis lineatus (Gray, 1835)
(Fig. 7 c)
Material examined. MNHN 2002.0442 (female; SVL 355 mm, TaL 15 mm), Lubuksao, Province of Sumatera Barat, elev. ca 400 m; MNHN 2002.0444 (male; SVL 160 mm, TaL 13 mm), 3 km South of Maninjau, western shore of Lake Maninjau, Province of Sumatera Barat, elev. ca 500 m.
Taxonomic comments. This species was previously placed in the genus Maticora Gray, 1835.
Six subspecies of Calliophis bivirgatus (Boie, 1827) are currently recognized (see David & Vogel, 1996) of which two occur on Sumatra more or less in sympatry in several provinces: C. intestinalis intestinalis (Laurenti, 1768) and C. intestinalis lineatus. The taxonomy of this species is badly in need of a revision.
Scalation of MNHN 2002.0442: DSR 13-13-13; VEN 268; SC 14.
Distribution on Sumatra. Provinces of Aceh, Sumatera Utara, Sumatera Barat, Jambi, Bengkulu, and Sumatera Selatan. Also Riau Archipelago (David & Vogel, 1996; De Lang, 2003).
Biology. The juvenile specimen MNHN 2002.0444 was active on a path at the limit between a garden and a disturbed forest at 1145 hours during a sunny day of August. When captured, the snake became very restless. The adult was found freshly wounded around 2000 hours on a road crossing a disturbed primary forest during a rainy night. Its stomach contained a scincid lizard Lygosoma quadrupes.
description: Published as part of Teynié, Alexandre, David, Patrick & Ohler, Annemarie, 2010, Note on a collection of Amphibians and Reptiles from Western Sumatra (Indonesia), with the description of a new species of the genus Bufo, pp. 1-43 in Zootaxa 2416 on page 26, DOI: 10.5281/zenodo.194395