cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The hidden diversity of the endemic Arctic sponges (Porifera)
Creators: name: Morozov, Grigori
name: Sabirov, Rushan
name: Anisimova, Natalya
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: The biogeographical analysis of the Barents Sea sponge fauna was undertaken on the basis of their modern distribution. Samples of sponges were collected in the Barents Sea during four annual multispecies trawl surveys (2003–2006) by the Knipovich Polar Research Institute of Marine Fisheries and Oceanography (PINRO) research vessels F. Nansen, Smolensk and Muklevich. Also, in 2019 fresh samples were collected during the benthic trawl survey by the PINRO research vessel F. Nansen. A total of 64 sponge species were studied. Among them, there was a large group of 24 (37.5% of the total number) boreal species – invaders from the North Atlantic, and their distribution in the Arctic Ocean is confined to the western Barents Sea. Since these species do not spread deep into the Arctic Ocean, they do not really affect the characteristics of the modern Arctic fauna. The second major component (24 species; 37.5%) of the Barents Sea sponge fauna (and the primary component of the modern Arctic fauna as a whole) is represented by Arctic endemics. A characteristic feature of some arctic sponges (endemics) is that there are pairs of morphologically and genetically close species inhabiting the North Atlantic. Their distributional ranges do not overlap significantly but are immediately adjacent to each other (vicariant species). The origin of vicariant species pairs among sponges inhabiting the Arctic and the adjoining North Atlantic was associated with glacial/interglacial cycles of the Quaternary, which drastically reorganised the boreal North Atlantic faunal elements that inhabited the Arctic Ocean in the Pliocene epoch. However, if we take a closer look not only at these species pairs but also at their close relatives inhabiting the North Atlantic, Arctic and North Pacific oceans, we see that they share the same roots as the North Pacific ones, and probably have evolved from the latter. The last species group, the arctic-boreal (16 species; 25%), is rather arbitrary and unified species of uncertain origin.
Background field method in the gradient flow
Creators: name: Suzuki, Hiroshi
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In perturbative consideration of the Yang--Mills gradient flow, it is useful to introduce a gauge non-covariant term ("gauge-fixing term") to the flow equation that gives rise to a Gaussian damping factor also for gauge degrees of freedom. In the present paper, we consider a modified form of the gauge-fixing term that manifestly preserves covariance under the background gauge transformation. It is shown that our gauge-fixing term does not affect gauge-invariant quantities as the conventional gauge-fixing term. The formulation thus allows a background gauge covariant perturbative expansion of the flow equation that provides, in particular, a very efficient computational method of expansion coefficients in the small flow time expansion. The formulation can be generalized to systems containing fermions.
description: 19 pages, the final version to appear in PTEP
Multivariate Fronthaul Quantization for Downlink C-RAN
Creators: name: Lee, Wonju
name: Simeone, Osvaldo
name: Kang, Joonhyuk
name: Shamai, Shlomo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: The Cloud-Radio Access Network (C-RAN) cellular architecture relies on the transfer of complex baseband signals to and from a central unit (CU) over digital fronthaul links to enable the virtualization of the baseband processing functionalities of distributed radio units (RUs). The standard design of digital fronthauling is based on either scalar quantization or on more sophisticated point to-point compression techniques operating on baseband signals. Motivated by network-information theoretic results, techniques for fronthaul quantization and compression that improve over point-to-point solutions by allowing for joint processing across multiple fronthaul links at the CU have been recently proposed for both the uplink and the downlink. For the downlink, a form of joint compression, known in network information theory as multivariate compression, was shown to be advantageous under a non-constructive asymptotic information-theoretic framework. In this paper, instead, the design of a practical symbol-by-symbol fronthaul quantization algorithm that implements the idea of multivariate compression is investigated for the C-RAN downlink. As compared to current standards, the proposed multivariate quantization (MQ) only requires changes in the CU processing while no modification is needed at the RUs. The algorithm is extended to enable the joint optimization of downlink precoding and quantization, reduced-complexity MQ via successive block quantization, and variable-length compression. Numerical results, which include performance evaluations over standard cellular models, demonstrate the advantages of MQ and the merits of a joint optimization with precoding.
description: Submitted
Tectaria poeppigii C. Chr., Index Filic., Suppl.
Creators: name: Kessler, Michael
name: Smith, Alan R.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Polypodiales
Tectariaceae
Tectaria
Tectaria poeppigii

description: Tectaria poeppigii (C.Presl) C.Chr., Index Filic., Suppl. 3: 183. 1934.
 Range: — Ecuador, Bolivia (CO); southeastern Brazil.
 Ecology: — Rare, known from three Bolivian collections: Kessler 13004, LPB, UC; Portugal 599, LPB, UC; Wood & Wasshausen 13922, UC); terrestrial in humid forests; 1300–1700 m. This last collection was cited as a paratype of T. jimenezii.
 Notes: —A large-fronded species, with entire pinnae to ca. 30 × 8 cm, excluding the basiscopic lobe on the proximal pinna pair, which is ca. 10 cm long. Sori in 2–4 regular to somewhat irregular rows between main lateral veins (to 1.5 cm apart); terminal blade segment large, to 30 cm, with two large basal lobes to ca. 15 × 4.5 cm; rachises nearly glabrous abaxially, with dense, uniform, glandular hairs to 0.1 mm adaxially; costae glabrous or nearly so abaxially; indusia peltate or nearly so, minutely glandular to glabrescent, ca. 1 mm diam; many sori tend to athyrioid (J-shaped), lunate, or elongate in this species, a feature seen on the last two collections cited above.
 On the surface, this species seems very similar to, and perhaps not distinguishable from T. sodiroi (Baker) Maxon, type from Ecuador, and ascribed to Colombia to Bolivia. This name was rejected by Tryon & Stolze (1993) because it was was a mixed collection and untypifiable; nonetheless, they placed the name in synonymy under T. antioquoiana. What has been called T. sodiroi in herbaria may be the same as T. chimborazensis (C.Chr.) C.Chr. also from Ecuador. If T. poeppigii is conspecific with any of these taxa, it has priority.
description: Published as part of Kessler, Michael & Smith, Alan R., 2018, Prodromus of a fern flora for Bolivia. XXXVIII. Tectariaceae, pp. 248-254 in Phytotaxa 334 (3) on page 252, DOI: 10.11646/phytotaxa.334.3.6, http://zenodo.org/record/13720948
Internet use and agricultural productivity in rural Vietnam
Creators: name: Nguyen, Thanh‐Tung
name: Nguyen, Trung Thanh
name: Grote, Ulrike
Publisher: name: Oxford [u.a.] : Wiley-Blackwell
Year: 2023
Subjects: subject: instrumental variable
subject: quantile regression
subject: rural household
subject: Vietnam
subject: Dewey Decimal Classification::300 | Sozialwissenschaften, Soziologie, Anthropologie::330 | Wirtschaft

description: The use of the internet is growing rapidly and has become an engine for economic development. However, few studies have examined the impact of internet use on agricultural production, and the results are not yet conclusive. Employing a dataset of more than 2000 observations in rural Vietnam, our study analyses the impact of internet use on agricultural productivity using the heteroscedasticity-based instrument approach suggested by Lewbel, Journal of Business and Economic Statistics, 2012, 30, 67–80 and examines the heterogeneity and distribution of the impact using quantile regressions. Our results show that internet use has significant and positive effects on agricultural productivity. However, these effects are heterogeneous across population groups. The positive effects of internet use are stronger for households with a lower level of education, with a young and female head, and from ethnic minorities. The benefits are also found to be skewed towards the group of farmers at the bottom of the productivity distribution. Therefore, we propose facilitating the diffusion of the internet, since it not only boosts agricultural productivity, but also reduces productivity inequality. In addition, we recommend promoting rural education, supporting local markets, investing more in irrigation systems, and facilitating farm mechanisation as these factors are found to contribute to increasing agricultural productivity.
FOREST-BASED TOURISM IN BANGLADESH: STATUS, PROBLEMS, AND PROSPECTS
Creators: name: Alam, Mahbubul
name: Furukawa, Yasushi
name: Akter, Salma
Publisher: name: tourismos
Year: 2010

description: Bangladesh is a land of diverse forest-based natural attractions throughout the evergreen, semi-evergreen, and mangrove forest ecosystems. The article attempts at exploring various dimensions of ecotourism industry and critically analyzes the relationship among the stakeholders, overall strength-weakness of ecotourism sector and impediments hindering its development. National Parks, Ecoparks, Wildlife Sanctuaries, Game Reserves, and the like have been developed in the natural forest ecosystems to attract tourists from home and abroad. Cheap transportation, lodging and associated costs, unique scenic beauty and wilderness of all sites and socio-cultural diversity of indigenous communities living in the forest together make up the strength of the industry as a whole. The study identifies a number of impediments, including conflict among the stakeholders and forest degradation hindering expansion of ecotourism industry. For sustainable development of forest-based tourism, traditional ‘Top-down’ management approach is suggested to avoid and voice of all stakeholders needs to be considered in decision-making.
description: tourismos, Vol. 5 No. 1 (2010)
Triplophyllum funestum Holttum, Kew Bull.
Creators: name: Kessler, Michael
name: Smith, Alan R.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Polypodiales
Tectariaceae
Triplophyllum
Triplophyllum funestum

description: Triplophyllum funestum (Kunze) Holttum, Kew Bull. 41(2): 255. 1986.
 Range: —Lesser Antilles; Guatemala to Bolivia (BE, CO, LP, PA, SC) and southeastern Brazil.
 Ecology: —Common; terrestrial in humid forests; to 1100 m.
 Notes: —Very variable, but this typically has less divided leaves (2-pinnate-pinnatifid) than the other two species (mostly 3-pinnate-pinnatifid).
description: Published as part of Kessler, Michael & Smith, Alan R., 2018, Prodromus of a fern flora for Bolivia. XXXVIII. Tectariaceae, pp. 248-254 in Phytotaxa 334 (3) on pages 252-253, DOI: 10.11646/phytotaxa.334.3.6, http://zenodo.org/record/13720948
Ubaldino Peruzzi a Raffaello Busacca (29 maggio 1857)
Creators: name: Peruzzi, Ubaldino
name: Busacca, Raffaello
Publisher: name: Zenodo
Year: 2023
Subjects: Accademia dei Georgofili
Peruzzi, Ubaldino
Busacca, Raffaello
Lettera
Letter
Carteggio
1857
Correspondence

description: Lettera di Ubaldino Peruzzi a Raffaello Busacca del 29 maggio 1857. Segnatura dell’unità documentale: Archivio storico dell’Accademia dei Georgofili, Carteggio, Busta, Natura: manoscritto. Consistenza: cc. 2
description: Digitalizzato come parte della Mostra virtuale: Ubaldino Peruzzi : un percorso in rete : in occasione del bicentenario della nascita https://www.georgofili.it/contenuti/ubaldino-peruzzi-un-percorso-in-rete/17485
Supplementary Material 4
Creators: name: Shamanna, Varun
Publisher: name: figshare
Year: 2022
Subjects: subject: 110303 Clinical Microbiology
subject: FOS: Clinical medicine
subject: 111706 Epidemiology
subject: FOS: Health sciences

description: This is the Supplementary Material 4 for the manuscript titled "Novel multi-drug resistant sub-lineages of Staphylococcus aureus Clonal Complex 22 discovered in India".
title: Lunate dislocation
Creators: name: Meersman, Pieter
Publisher: name: EURORAD
Year: 2023
Subjects: subject: Musculoskeletal system
subject: Bones
subject: Emergency
subject: Musculoskeletal joint
subject: Trauma
subject: CT
subject: Clinical Cases

description: Clinical History: A 34-year-old woman self-presented to the emergency department with left wrist pain, swelling and limited dorsiflexion following a fall on outstretched hand (FOOSH) injury during football. Pain was localized on the volar ulnar side of the wrist. Finger mobility was normal. Past medical history was insignificant.

description: 34 years, female
LKB1 loss links serine metabolism to DNA methylation and tumorigenesis
Creators: name: Nicolay, Brandon N.
name: Kottakis, Filippos
name: Li, Yvonne Y.
name: Karnik, Rahul
name: Hammerman, Peter S.
name: Meissner, Alexander
name: Roumane, Ahlima
name: Boukhali, Myriam
name: Hayward, Michele C.
name: Bardeesy, Nabeel
name: Dyson, Nicholas J.
name: Liesa, Marc
name: Wong, Kwok Kin
name: Gu, Hongcang
name: Shirihai, Orian S.
name: Hayes, D. Neil
name: Haas, Wilhelm
name: Chen, Ting
name: Nagle, Julia M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Intermediary metabolism generates substrates for chromatin modification, enabling the potential coupling of metabolic and epigenetic states. Here we identify a network linking metabolic and epigenetic alterations that is central to oncogenic transformation downstream of the liver kinase B1 (LKB1, also known as STK11) tumour suppressor, an integrator of nutrient availability, metabolism and growth. By developing genetically engineered mouse models and primary pancreatic epithelial cells, and employing transcriptional, proteomics, and metabolic analyses, we find that oncogenic cooperation between LKB1 loss and KRAS activation is fuelled by pronounced mTOR-dependent induction of the serine-glycine-one-carbon pathway coupled to S-adenosylmethionine generation. At the same time, DNA methyltransferases are upregulated, leading to elevation in DNA methylation with particular enrichment at retrotransposon elements associated with their transcriptional silencing. Correspondingly, LKB1 deficiency sensitizes cells and tumours to inhibition of serine biosynthesis and DNA methylation. Thus, we define a hypermetabolic state that incites changes in the epigenetic landscape to support tumorigenic growth of LKB1-mutant cells, while resulting in potential therapeutic vulnerabilities.
Triplophyllum perpilosum J. Prado & R. C. Moran, Brittonia
Creators: name: Kessler, Michael
name: Smith, Alan R.
Publisher: name: Zenodo
Year: 2018
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Polypodiales
Tectariaceae
Triplophyllum
Triplophyllum perpilosum

description: Triplophyllum perpilosum (Holttum) J.Prado & R.C.Moran, Brittonia 60(2): 126. 2008.
 Range: —Eastern Colombia (Macarena massif); eastern Bolivia (SC).
 Ecology: —Rare; terrestrial in humid forests on sandstone; 350–1000 m.
description: Published as part of Kessler, Michael & Smith, Alan R., 2018, Prodromus of a fern flora for Bolivia. XXXVIII. Tectariaceae, pp. 248-254 in Phytotaxa 334 (3) on page 253, DOI: 10.11646/phytotaxa.334.3.6, http://zenodo.org/record/13720948
Exploring the evolutionary success of the antibiotic resistant Salmonella Kentucky ST198
Creators: name: Albasiony, Alaa
name: Ceyssens, Pieter-Jan
name: Aertsen, Abram
Publisher: name: Zenodo
Year: 2022

description: Aim: Salmonella enterica serovar Kentucky (S. Kentucky) is a common causative agent of gastroenteritis in humans. It is one of most notorious Salmonella serotypes, as it is strongly associated with antimicrobial resistance. Ciprofloxacin-resistant S. Kentucky (CIPR S. Kentucky) belongs to a single sequence type (ST198), which recently acquired chromosomally encoded blaCTX-M-14b and spread across the EU continent, which was subject to urgent Inquiry (UI-464) of the ECDC. This PhD research elucidates this transposition from plasmid-borne to chromosomal resistance in single-cell resolution, and investigate several factors that drive the resistance acquisition. Methods: We are developing fluorescent reporters based on two orthogonal parS/ParB systems to differentially label the plasmid backbone and the ISEcp1-bla CTX-M-14b unit. The reporter systems should enable studying the dynamics of conjugation and transposition at a cellular level using time-lapse fluorescent microscopy and microfluidics Results:  In Salmonella spp., the resistance genes are largely encoded on mega-plasmids belonging to the incompatibility group H (IncH). Comparative genomic analysis of ESBL-producing S. Kentucky in Europe indicated a chromosomal integration of 2.5KB plasmid fragment harboring the bla CTX-M-14b adjacent to an insertion-like sequence- ISEcp1. ISEcp1 can mobilize bla CTX-M gene from the plasmid to the chromosome and enhances its expression. During the first year of this PhD project (KENTUCKY) we cloned the transposition unit (TU) containing ISEcp1-bla CTX-M-14b into a prototype IncHI plasmid, R27. Next, We labeled the R27 backbone and TU with Phage-derived and Lactococcus lactis-derived parS sequences, respectively. Conclusions: The transposition of resistance genes from plasmid to chromosome adds an important dimension to the bacterial resistance, as it fixes the AMR gene by vertical evolution. Understanding the drivers of this transfer can help to control its occurrence.
A Multi-scale Monte Carlo Method for Electrolytes
Creators: name: Liang, Yihao
name: Xu, Zhenli
name: Xing, Xiangjun
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Artifacts arise in the simulations of electrolytes using periodic boundary conditions (PBC). We show the origin of these artifacts are the periodic image charges and the constraint of charge neutrality inside the simulation box, both of which are unphysical from the view point of real systems. To cure these problems, we introduce a multi-scale Monte Carlo method, where ions inside a spherical cavity are simulated explicitly, whilst ions outside are treated implicitly using continuum theory. Using the method of Debye charging, we explicitly derive the effective interactions between ions inside the cavity, arising due to the fluctuations of ions outside. We find that these effective interactions consist of two types: 1) a constant cavity potential due to the asymmetry of the electrolyte, and 2) a reaction potential that depends on the positions of all ions inside. Combining the Grand Canonical Monte Carlo (GCMC) with a recently developed fast algorithm based of image charge method, we perform a multi-scale Monte Carlo simulation of symmetric electrolytes, and compare it with other simulation methods, including PBC+GCMC method, as well as large scale Monte Carlo simulation. We demonstrate that our multi-scale MC method is capable of capturing the correct physics of a large system using a small scale simulation.
description: 14 pages, 11 figures
Spektrum : das Magazin der Technischen Universität Hamburg (TUHH), Ausgabe 02/2023
Creators: name: Präsident Der Technischen Universität Hamburg (Ed.)
Publisher: name: TUHH Universitätsbibliothek
Year: 2023
Subjects: classificationCode: 370
subject: Education
classificationCode: 500
subject: Science
classificationCode: 600
subject: Technology
classificationCode: 620
subject: Engineering and Applied Operations

description: Die letzte Meile : Pakete und Briefe CO₂-frei zustellen ; Sauberes Trinkwasser : sichere Versorgung für Europa ; Klimaforschung : Messtechnik für genaue Vorhersagen
NMDAR inhibition-independent antidepressant actions of ketamine metabolites
Creators: name: Morris, Patrick J.
name: Yuan, Peixiong
name: Fang, Yuhong
name: Mayo, Cheryl L.
name: Huang, Xi-Ping
name: Gould, Todd D.
name: Dossou, Katina S. S.
name: Moaddel, Ruin
name: Wainer, Irving W.
name: Thomas, Craig J.
name: Thompson, Scott M.
name: Fischell, Jonathan
name: Albuquerque, Edson X.
name: Alkondon, Manickavasagom
name: Pribut, Heather J.
name: Singh, Nagendra S.
name: Zanos, Panos
name: Elmer, Greg I.
name: Zarate, Carlos A.
name: Georgiou, Polymnia
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Major depressive disorder afflicts ~16 percent of the world population at some point in their lives. Despite a number of available monoaminergic-based antidepressants, most patients require many weeks, if not months, to respond to these treatments, and many patients never attain sustained remission of their symptoms. The non-competitive glutamatergic N-methyl-D-aspartate receptor (NMDAR) antagonist, (R,S)-ketamine (ketamine), exerts rapid and sustained antidepressant effects following a single dose in depressed patients. Here we show that the metabolism of ketamine to (2S,6S;2R,6R)-hydroxynorketamine (HNK) is essential for its antidepressant effects, and that the (2R,6R)-HNK enantiomer exerts behavioural, electroencephalographic, electrophysiological and cellular antidepressant actions in vivo. Notably, we demonstrate that these antidepressant actions are NMDAR inhibition-independent but they involve early and sustained α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor activation. We also establish that (2R,6R)-HNK lacks ketamine-related side-effects. Our results indicate a novel mechanism underlying ketamine’s unique antidepressant properties, which involves the required activity of a distinct metabolite and is independent of NMDAR inhibition. These findings have relevance for the development of next generation, rapid-acting antidepressants.
Probing the statistical properties of CMB $B$-mode polarization through Minkowski Functionals
Creators: name: Santos, Larissa
name: Wang, Kai
name: Zhao, Wen
Publisher: name: arXiv
Year: 2015
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The detection of the magnetic type $B$-mode polarization is the main goal of future cosmic microwave background (CMB) experiments. In the standard model, the $B$-mode map is a strongly non-gaussian field due to the lensed component. Besides the two-point correlation function, the other statistics are also very important to dig the information of the polarization map. In this paper, we employ the Minkowski functionals to study the morphological properties of the lensed $B$-mode maps. We find that the deviations from Gaussianity are very significant for both full and partial-sky surveys. As an application of the analysis, we investigate the morphological imprints of the foreground residuals in the $B$-mode map. We find that even for very tiny foreground residuals, the effects on the map can be detected by the Minkowski functional analysis. Therefore, it provides a complementary way to investigate the foreground contaminations in the CMB studies.
description: 29 pages, 22 figures, 7 tables, JCAP accepted
Thermodynamics of 5-flavor QCD
Creators: name: Neumann, Marius
Publisher: name: Universität Bielefeld
Year: 2023
Subjects: subject: 530

description: This thesis investigates the chiral phase transition in Quantum Chromodynamics (QCD) with five mass degenerate quark flavors. After performing lattice QCD simulations, I discuss measurements of the chiral condensate at small masses and classify the chiral phase transition. The data analysis is done via established approaches, as well as state-of-the-art machine learning means. That way, I introduce the Masked Autoregressive Flow (MAF) and the Vision Transformer (ViT) to QCD data analysis. This approach is used to identify a critical mass marking the boundary between first-order and crossover regions. Another part of this thesis analyzes scaling functions in the 3-d, Z(2), O(2) and O(4) universality classes and their finite size dependence using Monte Carlo simulations of improved ϕ⁴ models. We extract parametrizations of the Z(2) and O(2) scaling functions to high precisions by fitting data from simulations of the respective spin models.
Proteogenomics connects somatic mutations to signalling in breast cancer
Creators: name: Yan, Ping
name: Petralia, Francesca
name: Wang, Pei
name: Huang, Kuan-Lin
name: Davies, Sherri R.
name: Carr, Steven A.
name: Mesri, Mehdi
name: Wang, Xianlong
name: Mani,
name: Krug, Karsten
name: Wilkerson, Matthew
name: Paulovich, Amanda G.
name: Fenyö, David
name: Ruggles, Kelly V.
name: Lei, Jonathan T.
name: Mertins, Philipp
name: Kawaler, Emily
name: Qiao, Jana W.
name: Tu, Zhidong
name: Wang, Jing
name: Clauser, Karl R.
name: Ellis, Matthew J.
name: Kinsinger, Christopher R.
name: Gatza, Michael L.
name: Lin, Chenwei
name: Cao, Song
name: Mundt, Filip
name: Yellapantula, Venkata
name: Townsend, R. Reid
name: Gillette, Michael A.
name: Zhang, Bing
name: Ding, Li
name: Skates, Steven J.
name: Rodriguez, Henry
name: Perou, Charles M.
name: McLellan, Michael D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Somatic mutations have been extensively characterized in breast cancer, but the effects of these genetic alterations on the proteomic landscape remain poorly understood. We describe quantitative mass spectrometry-based proteomic and phosphoproteomic analyses of 105 genomically annotated breast cancers of which 77 provided high-quality data. Integrated analyses allowed insights into the somatic cancer genome including the consequences of chromosomal loss, such as the 5q deletion characteristic of basal-like breast cancer. The 5q trans effects were interrogated against the Library of Integrated Network-based Cellular Signatures, thereby connecting CETN3 and SKP1 loss to elevated expression of EGFR, and SKP1 loss also to increased SRC. Global proteomic data confirmed a stromal-enriched group in addition to basal and luminal clusters and pathway analysis of the phosphoproteome identified a G Protein-coupled receptor cluster that was not readily identified at the mRNA level. Besides ERBB2, other amplicon-associated, highly phosphorylated kinases were identified, including CDK12, PAK1, PTK2, RIPK2 and TLK2. We demonstrate that proteogenomic analysis of breast cancer elucidates functional consequences of somatic mutations, narrows candidate nominations for driver genes within large deletions and amplified regions, and identifies therapeutic targets.
title: Whetstone: Stanislaus Joyce and the Fraternal Relationships in ‘Finnegans Wake’
Creators: name: Farrell, Melissa
Publisher: name: University of Liverpool Repository
Year: 2021

description: This thesis examines Finnegans Wake (1939) by the Irish writer James Joyce (1882-1941). By first tracing the familial, spiritual, and financial relationships Joyce had with his brother Stanislaus (1884-1955) and identifying early references to Stanislaus in Joyce’s writings, this research shows how the fraternal relationship was incorporated into the Wake by examining five passages therein. Over the course of their lives, Joyce and Stanislaus’ relationship was subject to the stressors of abuse, poverty, and death which followed them from Dublin to Trieste. Their differences, eventually, were greater than their similarities, and Joyce explored this dichotomy in his writings. Fundamentally, this thesis argues that Joyce’s relationship with Stanislaus is the primary influence on the interactions between Shem and Shaun in the Wake. One of the key innovations of this thesis is its methodology. Throughout, archival materials are used to show the parallels between Joyce’s relationship with Stanislaus and that of the brothers in the Wake. Analysis of the process of authorial revision shows how, by editing and expanding his previous drafts, Joyce used the book to respond to real-life events. Each chapter of this thesis scrutinises extracts of the Wake to show the influence of history, literature, and popular culture on the composition of his fraternal characters. In so doing, the research expands on Joyce’s reactions to contemporary philosophy and personal criticism, and his interest in subjects diverse as French art, Irish geology, and Viking settlers – and how he uses all of these to provide a thematic backdrop for the story of the brothers. In showing the direct influence Stanislaus had on Joyce’s early writings, this thesis examines from a new perspective the contested topic of authorship in the latter’s work. It brings together the story of how Stanislaus contributed titles, names of characters, ideas about structure, and eventually his own personality to his elder brother’s texts. By demonstrating the imbalance that Joyce perpetrated and perpetuated in his relationship with his brother, and the way he used that imbalance to furnish his own books, this research lays the groundwork for further scholarly examination of the interplay between the various members of Joyce’s family and the role of the family in his works. Finally, by demonstrating the symbols, patterns, and structural models Joyce uses to refer to Stanislaus, and the ways he embeds them in the Wake, this thesis suggests ways in which Stanislaus himself might be reassessed considering Joyce’s writings.
MEASURING TOURIST MOTIVATION: DO SCALES MATTER?
Creators: name: Huang, Songshan
Publisher: name: tourismos
Year: 2010

description: Measuring tourist motivation has always been a challenging task for tourism researchers. This paper aimed to increase the understanding of tourist motivation measurement by comparing two frequently adopted motivation measurement approaches: self-perception (SP) and importance-rating (IR) approaches. Results indicated that both SP and IR scales were highly reliable in terms of internal consistency. However, respondents tended to rate more positively in the SP scale than in the IR scale. Factor analyses extracted similar underlying structures from the two measurements, with each factor explaining almost the same amount of variances across the two scales. The study suggested that both scales could be regarded as appropriate instruments for measuring tourist motivation, because they seemed to measure the same underlying construct with high reliability.
description: tourismos, Vol. 5 No. 1 (2010)
LET-715: SYBCI Transmittal Letter for the B7, B10, and K5 Feeder Lines Replacement Project
Creators: name: Ryan, Christopher
Publisher: name: 30 CES/CEIEA
Year: 2017
Subjects: subject: Santa Barbara (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/3486/santa-barbara-county
subject: Vandenberg Air Force Base (VAFB)
valueUri: https://core.tdar.org/browse/geographic-keyword/85469/vandenberg-air-force-base-vafb
subject: California (State / Territory)
valueUri: https://core.tdar.org/browse/geographic-keyword/1484/california-state-territory
subject: Santa Ynez Band of Chumash Indians
valueUri: https://core.tdar.org/browse/culture-keyword/9355/santa-ynez-band-of-chumash-indians
subject: CA-SBA-2426
valueUri: https://core.tdar.org/browse/site-name/100737/ca-sba-2426
subject: low-density lithic scatter
valueUri: https://core.tdar.org/browse/site-type/3928/low-density-lithic-scatter
subject: Lithic Scatter
valueUri: https://core.tdar.org/browse/site-type/490/lithic-scatter
subject: Chipped Stone
valueUri: https://core.tdar.org/browse/material-type/2/chipped-stone
subject: Section 106
valueUri: https://core.tdar.org/browse/other-keyword/67760/section-106
subject: National Historic Preservation Act (NHPA)
valueUri: https://core.tdar.org/browse/other-keyword/167421/national-historic-preservation-act-nhpa
subject: National Register of Historic Places
valueUri: https://core.tdar.org/browse/other-keyword/1572/national-register-of-historic-places
subject: area of potential effects (APE)
valueUri: https://core.tdar.org/browse/other-keyword/167285/area-of-potential-effects-ape
subject: B10
valueUri: https://core.tdar.org/browse/other-keyword/167419/b10
subject: K5
valueUri: https://core.tdar.org/browse/other-keyword/167420/k5
subject: overhead electrical distribution lines
valueUri: https://core.tdar.org/browse/other-keyword/167417/overhead-electrical-distribution-lines
subject: B7
valueUri: https://core.tdar.org/browse/other-keyword/167418/b7
subject: Archaeological Overview
valueUri: https://core.tdar.org/browse/investigation-type/1/archaeological-overview
subject: Consultation
valueUri: https://core.tdar.org/browse/investigation-type/4/consultation

description: This document is a SYBCI transmittal letter to the Santa Ynez Band of Chumash Indians for the B7, B10, and K5 Feeder Lines Replacement Project (Project). Vandenberg Air Force Base (VAFB) determined that the Project was an undertaking subject to compliance with Section 106 of the National Historic Preservation Act of 1966, as amended, and would comply with Section 106 using the implementing regulations [36 CFR Part 800]. With this letter and its attachment (Identification of Historic Properties: B7, B10, K5 Feeder Lines Replacement), VAFB initiated consultation with the Tribe regarding potential impacts to cultural resources. VAFB delineated the are of potential effects (APE) and carried out a reasonable and good faith effort to identify historic properties within the APE. The attached report describes the proposed project and provides details about the site. The letter requests written views from the Tribe regarding the project via either letter or e-mail.
Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala
Creators: name: Thiele, Todd E.
name: Kozicz, Tamas
name: Deisseroth, Karl
name: Navarro, Montserrat
name: Mazzone, Christopher M.
name: Halladay, Lindsay R.
name: Burnham, Nathan
name: Cristiano, Claudia
name: Hardaway, J. Andrew
name: Holmes, Andrew
name: Dorrier, Cayce E.
name: Tipton, Gregory J.
name: Heisler, Lora K.
name: Marcinkiewcz, Catherine A.
name: D'Agostino, Giuseppe
name: Ramakrishnan, Charu
name: Diberto, Jeffrey F.
name: Kash, Thomas L.
name: McElligott, Zoe A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Serotonin (5-hydroxytryptamine; 5-HT) is a neurotransmitter that has an essential role in the regulation of emotion. The precise circuits through which aversive states are orchestrated by 5-HT, however, have not yet been defined. Here we show that 5-HT from the dorsal raphe nucleus (5-HTDRN) enhances fear and anxiety and activates a subpopulation of corticotropin-releasing factor (CRF) neurons in the bed nucleus of the stria terminalis (CRFBNST). Specifically, 5-HTDRN projections to the BNST, via actions at 5-HT2C receptors (5-HT2CRs), engage a CRFBNST inhibitory microcircuit that silences anxiolytic BNST outputs to the ventral tegmental area (VTA) and lateral hypothalamus (LH). Further, we demonstrate that this CRFBNST inhibitory circuit underlies aversive behavior following acute exposure to selective serotonin reuptake inhibitors (SSRIs). This early aversive effect is mediated via the corticotrophin releasing factor type 1 receptor (CRF1R) given that CRF1R antagonism is sufficient to prevent acute SSRI-induced enhancements in aversive learning. These results reveal an essential 5-HTDRN→CRFBNST circuit governing fear and anxiety and provide a potential mechanistic explanation for the clinical observation of early adverse events to SSRI treatment in some patients with anxiety disorders1,2.
LIAISON: Outils pour l'évaluation et l'analyse d'impact de la co-innovation
Creators: name: Macken-Walsh, Áine
name: Augustyn, Anna Maria
name: Bettoni, Maddalena
name: Puente, José María Díaz
name: Forde, Aoife
name: Home, Robert
name: Javornicky, Martin
name: Naughton, Anita
name: Quiédeville, Sylvain
name: Repede, Dana Cristina
Publisher: name: Zenodo
Year: 2022

description: Ce guide présente une série de méthodes et d’outils qui peuvent être utilisés pour l’évaluation et l’analyse d’impact de tout projet ou autre initiative impliquant des groupes travaillant ensemble pour la co-innovation. Ce guide s’adresse à toute personne qui souhaite évaluer, suivre et améliorer un processus de co-innovation en cours, qu’il s’agisse d’un projet formel ou d’une collaboration plus informelle.
title: The Physical and Chemical Origins of Amyloid at Interfaces
Creators: name: Cumberbatch, Nathan
Publisher: name: University of Liverpool Repository
Year: 2021

description: Amyloidosis is of serious concern within the modern world with an ageing global population, there is a significant drive to understand how amyloid forms in order to research and develop new therapeutics to combat this threat. This thesis proposes using a cross-disciplinary collaborative approach to determine multiple aspects within the amyloid-like fibrillation pathway for human insulin (HI) at acidic and neutral pH conditions. Chapter 2 uses Reflection Anisotropy Spectroscopy to obtain fibrillar orientation information with the goal to investigate whether structural morphology can direct fibril growth. Lack of reproducibility at the surfaces and the observation of a ‘blue-haze’ on the silicon wafers led to the method development in Chapter 3. Chapter 4 uses conventional biophysical techniques, fluorescence spectroscopy and electron microscopy to study hydrophobic functionalised mesoporous silica microparticles provides a scaffold for human insulin fibrillation to occur. These results show that the microparticles induced fibril morphology changes and inhibited or enhanced the fibrillation process, with respect to the human insulin control. Chapter 5 explores the mass and structural changes of adsorbed human insulin at a hydrophobic surface, by QCM-D and Raman spectroscopy. The results of which showed variable human insulin adsorption to the two differing hydrophobically functionalised surfaces at pH 2 and pH 7 conditions. Chapter 6 is the result of a collaboration with the Department of Physics and provides the first images obtained from infrared scanning near-field optical microscopy in reflection with a quantum cascade laser source of human insulin adsorbed to gold surfaces to obtain both structural and locational information. These preliminary results provide exciting opportunities for future development of this technique at other surfaces and proteins. Chapter 7 uses fluorescence excitation – emission matrices to uncover the origin of the deep-blue autofluorescence phenomenon, with human insulin, α-synuclein and other peptides.
Structure-based discovery of opioid analgesics with reduced side effects
Creators: name: Sassano, Maria F.
name: Manglik, Aashish
name: Kobilka, Brian K.
name: Lin, Henry
name: Kling, Ralf C.
name: Hübner, Harald
name: Roth, Bryan L.
name: Giguère, Patrick M.
name: Aryal, Dipendra K.
name: Shoichet, Brian K.
name: Löber, Stefan
name: Gmeiner, Peter
name: Dengler, Daniela
name: Corder, Gregory
name: Levit, Anat
name: Bernat, Viachaslau
name: Huang, Xi-Ping
name: Scherrer, Grégory
name: McCorvy, John D.
name: Duan, Da
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Morphine is an alkaloid from the opium poppy used to treat pain. The potentially lethal side effects of morphine and related opioids—which include fatal respiratory depression—are thought to be mediated by μ-opioid-receptor (μOR) signalling through the β-arrestin pathway or by actions at other receptors. Conversely, G-protein μOR signalling is thought to confer analgesia. Here we computationally dock over 3 million molecules against the μOR structure and identify new scaffolds unrelated to known opioids. Structure-based optimization yields PZM21—a potent Gi activator with exceptional selectivity for μOR and minimal β-arrestin-2 recruitment. Unlike morphine, PZM21 is more efficacious for the affective component of analgesia versus the reflexive component and is devoid of both respiratory depression and morphine-like reinforcing activity in mice at equi-analgesic doses. PZM21 thus serves as both a probe to disentangle μOR signalling and a therapeutic lead that is devoid of many of the side effects of current opioids.
Comparative Analysis of the Approaches to Ensuring Unreasonable Limits are Not Imposed on the Right to Freedom of Expression by the Defamation Legislation of Jamaica, Australia and England & Wales Within the Context of the Internet: Assessment of the Efficacy of the Jamaican Defamation Act 2013.
Creators: name: Lewis, Coleen B.
Publisher: name: University of Leicester
Year: 2023
Subjects: Uncategorized

description: In 2013, the Jamaican Parliament enacted the Defamation Act with the object to, inter alia, address the rules within its pre-existing defamation laws, that were identified, in substance and operation, as being problematic as they exerted a disproportionate chilling effect on the right to freedom of expression in favour of the protection of reputation. The thesis asserts that, based on an examination of theories on the importance of the right to freedom of expression and reputation, the underlying values of each and their equal normative value and status as fundamental human rights, there is no justification for unreasonable restrictions to be imposed on the right to freedom of expression, in favour of the protection of reputation. To assess the efficacy of the Jamaican Defamation Act 2013, this thesis engages in a comparative analysis of the Jamaica Defamation Act 2013 and the approaches undertaken in Australia and England and Wales in their respective defamation legislation to address same or similar problems. This thesis focuses on a few of the pre 2013 defamation rules that were identified as problematic, specifically, the presumption of harm, strict liability rule, lengthy limitation periods, and the lack of workable defences for defamatory publications to the world at large on topics of public importance and interest. Additionally, the thesis scrutinizes how the relevant approaches of the comparative jurisdictions would apply where the right to freedom of expression is exercised via the Internet platform.Based on the comparative analysis, it is concluded that the Jamaican Defamation Act 2013 did not go far enough to resolve the problems within the pre 2013 defamation law, and that the distinct features of Internet publications make it even more difficult, if not impossible, to satisfy the featured object of the Jamaican Defamation Act 2013.
Self-consistent phonon calculations of lattice dynamical properties in cubic SrTiO$_{3}$ with first-principles anharmonic force constants
Creators: name: Tadano, Terumasa
name: Tsuneyuki, Shinji
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We present an \textit{ab initio} framework to calculate anharmonic phonon frequency and phonon lifetime that is applicable to severely anharmonic systems. We employ self-consistent phonon (SCPH) theory with microscopic anharmonic force constants, which are extracted from density-functional calculations using the least absolute shrinkage and selection operator technique. We apply the method to the high-temperature phase of SrTiO$_{3}$ and obtain well-defined phonon quasiparticles that are free from imaginary frequencies. Here we show that the anharmonic phonon frequency of the antiferrodistortive mode depends significantly on the system size near the critical temperature of the cubic-to-tetragonal phase transition. By applying perturbation theory to the SCPH result, phonon lifetimes are calculated for cubic SrTiO$_{3}$, which are then employed to predict lattice thermal conductivity using the Boltzmann transport equation within the relaxation-time approximation. The presented methodology is efficient and accurate, paving the way toward a reliable description of thermodynamic, dynamic, and transport properties of systems with severe anharmonicity, including thermoelectric, ferroelectric, and superconducting materials.
description: 11 pages, 7 figures
Surface patterning of nanoparticles with polymer patches
Creators: name: Xin, Huolin L.
name: Galati, Elizabeth
name: Choueiri, Rachelle M.
name: Rubinstein, Michael
name: Querejeta-Fernández, Ana
name: Gang, Oleg
name: Kumacheva, Eugenia
name: Han, Lili
name: Zhulina, Ekaterina B.
name: Larin, Egor M.
name: Thérien-Aubin, Héloise
name: Klinkova, Anna
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: Patterning of colloidal particles with chemically or topographically distinct surface domains (patches) has attracted intense research interest1–3. Surface-patterned particles act as colloidal analogues of atoms and molecules4,5, serve as model systems in studies of phase transitions in liquid systems6, behave as ‘colloidal surfactants’7 and function as templates for the synthesis of hybrid particles8. The generation of micrometre- and submicrometre-sized patchy colloids is now efficient9–11, but surface patterning of inorganic colloidal nanoparticles with dimensions of the order of tens of nanometres is uncommon. Such nanoparticles exhibit size- and shape-dependent optical, electronic and magnetic properties, and their assemblies show new collective properties12. At present, nanoparticle patterning is limited to the generation of two-patch nanoparticles13–15, and nanoparticles with surface ripples16 or a ‘raspberry’ surface morphology17. Here we demonstrate nanoparticle surface patterning, which utilizes thermodynamically driven segregation of polymer ligands from a uniform polymer brush into surface-pinned micelles following a change in solvent quality. Patch formation is reversible but can be permanently preserved using a photocrosslinking step. The methodology offers the ability to control the dimensions of patches, their spatial distribution and the number of patches per nanoparticle, in agreement with a theoretical model. The versatility of the strategy is demonstrated by patterning nanoparticles with different dimensions, shapes and compositions, tethered with various types of polymers and subjected to different external stimuli. These patchy nanocolloids have potential applications in fundamental research, the self-assembly of nanomaterials, diagnostics, sensing and colloidal stabilization.
ECONOMIC IMPLICATIONS OF INTERNATIONAL TOURISM ON TURKISH ECONOMY
Creators: name: Akal, Mustafa
Publisher: name: tourismos
Year: 2010

description: This study outlines, with a review of earlier studies, the effects of international tourism by showing developments in tourism-related economic parameters and discusses the implications of such tourism on the economy of Turkey. It asks how far international tourism contributes to the economic growth and development of Turkey; how far the country fully values its tourism potential by varying the focus of tourism facilities beyond the sun-sea-sand type of tourism, in order to lead to development of the industry countrywide and contribute further to economic growth; and other positive and negative effects of international tourism on the economy.
description: tourismos, Vol. 5 No. 1 (2010)