cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Targeting Connexins to Promote Functional Neural Repair and Regeneration
Creators: name: Cooke, Donald M.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Gap junctions
Connexins
Pannexins
Drug discovery

description: The connexins are a family of 21 proteins that represent the structural units of intercellular gap junctions and single membrane hemichannels. These channels provide a means for cells to exchange small metabolites and signaling molecules with adjacent cells and the extracellular space, respectively. Compelling evidence implicates connexins, and the more recently discovered pannexins, in the control of neural progenitor cell proliferation, survival and migration. Moreover, connexin and pannexin dysregulation following central nervous system injuries such as cerebral ischemia, spinal cord injury, and epilepsy contributes to the secondary expansion of lesions days and weeks after the initial insult. While these data suggest that connexins and pannexins represent novel therapeutic targets to both reduce the extent of neural injury and promote neural repair and regeneration, we currently lack the necessary repertoire of therapeutically useful connexin- and pannexin-specific compounds to test these hypotheses. In this thesis, I conducted targeted screening of a large, ethnobotanically-derived library to address my overarching objective of identifying compounds that selectively alter connexin and/or pannexin channel function. To accomplish this, I characterized the repertoire of connexins and pannexins expressed by neural progenitor cell-like NT2/D1 cells, quantified the intercellular flux of calcein through connexin gap junctions, and measured the uptake of lucifer yellow and propidium iodide through pannexin hemichannels. Collectively, these screens identified several promising lead compounds and ethanolic plant extracts that selectively alter connexin and pannexin channel activity.
title: Wertigkeit der Magnetresonanztomografie (MRT) zur Verlaufskontrolle entzündlicher subglottischer Stenosen (SGS) bei Patienten mit Granulomatose mit Polyangiitis (GPA)
Creators: name: Grebe, Paulina
name: Henes, Frank Oliver
name: Petersen, Jana
name: Iking-Konert, Christof
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Eine SGS bei GPA ist häufig medikamentös frustran zu behandeln und beeinträchtigt in hohem Maße die Lebensqualität. Zur Bestimmung des Stenosegrades sowie zur Verlaufsbeurteilung der entzündlichen Aktivität ist die endoskopische Untersuchung (meist durch[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
title: Targeting CD38 in Systemic Lupus erythematosus
Creators: name: Ostendorf, Lennard
name: Urbicht, Marie
name: Durek, Pawel
name: Heinz, Gitta Anne
name: Heinrich, Frederik
name: Garantziotis, Panagiotis
name: Enghard, Philipp
name: Biesen, Robert
name: Schneider, Udo
name: Burmester, Gerd-Rüdiger
name: Radbruch, Andreas
name: Mei, Henrik
name: Mashereghi, Mir-Farzin
name: Hiepe, Falk
name: Alexander, Tobias
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: Depletion of long-lived plasma cells (PC) represents a novel therapeutic concept for the treatment systemic lupus erythematosus (SLE), which derived from preclinical models and our experiences with autologous stem-stem cell transplantation and proteasome inhibition. However, these are [for full text, please go to the a.m. URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
The perception of balance in elite athletes' lives.
Creators: name: Amirault, Kimberley.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Health Sciences, Recreation.

description: Although the essential physical (Hollander, Meyers, & LeUnes, 1995; Krane, Greenleaf, & Snow, 1997) and mental (Bloom, 1985; Kreiner-Phillips & Orlick, 1993; Orlick & Partington, 1988) requirements of an elite athlete have been recognized as a necessity for excellence in sport, minimal research has examined the lives of these athletes as a whole and their perception of balance or imbalance in their life. The present study, therefore, set out to explore elite athletes' perceptions of balance in their lives. In depth, semi-structured interviews and modified self-reported diaries (Kramp, 1994) were conducted with 10 elite athletes (5 currently competing and 5 retired athletes). Inductive analysis of interview transcripts revealed that half of these athletes (2 current and 3 retired) defined balance primarily as having a vision or goal and striving towards it, while the other half (3 current and 2 retired) defined balance as respecting the different parts of their lives. Balance in these athletes' lives was perceived to fluctuate in cycles as it shifted in accordance with their needs and wants for that time in their life. In addition to highlighting the necessity of being true to themselves, important prerequisites for achieving balance in their lives were identified by all ten athletes. They stated that one must: (1) make a conscious decision to have balance; (2) have strong self discipline; (3) enjoy what you are doing; (4) have a supportive network; (5) have leisure time; and (6) be in the moment. Both the similarities and unique differences in the athletes' perspectives on balance were explored. Results from this study can be used to further advance the area of research that focuses on understanding balance in elite performers' lives.
On-line versus postal data collection: a re-examination of the response differences using demographically matched data
Creators: name: McDonald, Heath
name: Darbyshire, Penny
Publisher: name: Swinburne
Year: 2024

description: Past research has identified differences between online and mail collected responses to the same survey, but differences in the demographics of respondents had also been noted making the cause of the variation unclear. In the research reported here, responses to the same questionnaire, delivered via mail and internet surveys, were demographically matched across a range of variables. This removed the impact of response differences caused by age, gender, type of product consumed and length of customer relationship. Across all the different question types and response scales, significant differences were still found between mail and online respondents, even when data were ipsatised. Notably, online respondents were far less likely to use the end-points of the scale, perhaps indicating issues with the online collection methodology. The conclusion is that the two methods of data collection can not be assumed to be directly inter-changeable, and that the method used can lead to different results if not managed carefully.
title: Opinion 1/15: The Court of Justice Meets PNR Data (Again!)
Creators: name: Mendez, Mario
Publisher: name: European Papers (www.europeanpapers.eu)
Year: 2017
Subjects: subject: EU-Canada PNR Agreement
subject: personal data protection
subject: privacy
subject: EU Charter of Fundamental Rights
subject: PNR Agreements
subject: PNR Directive

description: European Papers - A Journal on Law and Integration, 2017 2(3), 803-818
description: I. Introduction. - II. Legal and factual background. - III. Opinion of AG Mengozzi. - IV. Opinion of the Court of Justice. - V. Analysis. - VI. Conclusion.
description: This Overview considers Opinion 1/15 of 26 July 2017 of the Court of Justice on the EU-Canada Passenger Name Record Agreement that concluded that the Agreement was not compatible with the Charter of Fundamental Rights of the European Union. Not only does the Canada Agree-ment now need renegotiating if it is to enter into force but also the existing Passenger Name Record Agreements with the United States and Australia need to be renegotiated. Crucially the EU's very own internal PNR regime will need to be revised if it is to meet the standards articulated in Opinion 1/15.
title: Bedeutung von Fatigue: Patient vs. Arzt – Ergebnisse eines Time-Trade-Off-Ansatz
Creators: name: Düsing, Christina
name: Schneider, Matthias
name: Chehab, Gamal
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Fatigue ist ein häufiges Symptom von SLE Patienten, das häufig einen wichtigen Einfluss auf die reduzierte Lebensqualität der Betroffenen hat. Ziel dieser Befragung war die Untersuchung des Leidensdruckes von SLE Patienten mit Fatigue und wie häufig Betroffene von ihren[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
TAT-Modified ω-Conotoxin MVIIA for Crossing the Blood-Brain Barrier
Creators: name: Yu, Shuo
name: Li, Yumeng
name: Chen, Jinqin
name: Zhang, Yue
name: Tao, Xinling
name: Dai, Qiuyun
name: Wang, Yutian
name: Li, Shupeng
name: Dong, Mingxin
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2019

description: As the first in a new class of non-opioid drugs, ω-Conotoxin MVIIA was approved for the management of severe chronic pains in patients who are unresponsive to opioid therapy. Unfortunately, clinical application of MVIIA is severely limited due to its poor ability to penetrate the blood-brain barrier (BBB), reaching the central nervous system (CNS). In the present study, we have attempted to increase MVIIA’s ability to cross the BBB via a fusion protein strategy. Our results showed that when the TAT-transducing domain was fused to the MVIIA C-terminal with a linker of varied numbers of glycine, the MVIIA-TAT fusion peptide exhibited remarkable ability to cross the bio-membranes. Most importantly, both intravenous and intranasal administrations of MVIIA-TAT in vivo showed therapeutic efficacy of analgesia. Compared to the analgesic effects of intracerebral administration of the nascent MVIIA, these systemic administrations of MVIIA-TAT require higher doses, but have much prolonged effects. Taken together, our results showed that TAT conjugation of MVIIA not only enables its peripheral administration, but also maintains its analgesic efficiency with a prolonged effective time window. Intranasal administration also rendered the MVIIA-TAT advantages of easy applications with potentially reduced side effects. Our results may present an alternative strategy to improve the CNS accessibility for neural active peptides.
title: Unterscheidung zwischen entzündlicher und fibrotischer Aktivität in IgG4-assoziierter Erkrankung
Creators: name: Ramming, Andreas
name: Schmidkonz, Christian
name: Rauber, Simon
name: Soare, Alina
name: Bergmann, Christina
name: Kleyer, Arnd
name: Manger, Bernhard
name: Distler, Jörg
name: Agaimy, Abbas
name: Kuwert, Torsten
name: Schett, Georg
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Gewebeschäden bei nicht-malignen Erkrankungen des Menschen können entweder durch übermäßige Entzündung oder durch überschießende fibrotische Reaktionen verursacht werden. Die molekularen und zellulären Grundlagen dieser beiden Prozesse, ihre Auswirkungen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
title: Etablierung eines Assays zum Nachweisvon funktionellen Autoantikörpern gegen den Angiotensin Typ I Rezeptor bei Patienten mit Kollagenerkrankungen
Creators: name: Bankamp, Lukas
name: Preuß, Beate
name: Pecher, Ann-Christin
name: Henes, Jörg
name: Klein, Reinhild
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Kollagenerkrankungen gehören zu den Autoimmunerkrankungen und betreffen in erster Linie Gefäße. Neben den klinischen Symptomen stellen Autoantikörper (Aak) gegen verschiedene Strukturen, wie z.B. Kernproteine, zytoplasmatische Antigene oder Phospholipide ein wichtiges[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Triggering the Passivation Effect of Potassium Doping in Mixed-Cation Mixed-Halide Perovskite by Light Illumination
Creators: name: Zheng, Fei
name: Chen, Weijian
name: Bu, Tongle
name: Ghiggino, Kenneth P.
name: Huang, Fuzhi
name: Cheng, Yibing
name: Tapping, Patrick
name: Kee, Tak W.
name: Jia, Baohua
name: Wen, Xiaoming
Publisher: name: Swinburne
Year: 2024

description: Potassium (K + ) doping has been recently discovered as an effective route to suppress hysteresis and improve the performance stability of perovskite solar cells. However, the mechanism of these K + doping effects is still under debate, and rationalization of the improved performance in these perovskites is needed. Herein, the photoluminescence (PL) properties and device performance of mixed-cation mixed-halide perovskite are dynamically monitored with and without K + doping under bias light illumination via a confocal fluorescence microscope, together with ultrafast transient absorption as well as time-dependent and time-resolved PL measurements. It is demonstrated that illumination is essential to trigger the passivation effect of K + by forming KBr-like compounds, leading to the elimination of interface trapping defects and suppression of mobile ion migration, thus resulting in improved power conversion efficiency and negligible current–voltage hysteresis of solar cells. This work provides novel insight into the hysteresis suppression upon K + doping and highlights the significance of light illumination when using this protocol.
La critique de la démocratie des droits de l'homme chez Marcel Gauchet
Creators: name: Melancon, Jérôme
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Philosophy.

description: Marcel Gauchet propose une critique de la démocratie des droits de l'homme qui est fondée d'une part sur sa compréhension de la modernité et, d'autre part, sur ses thèses quant à l'être du social. Ces thèses lui permettent non seulement d'affirmer que la démocratie est un régime normal, car elle laisse libre cours à la condition historique de l'humanité, mais elles lui permettent aussi, en tant qu'elles forment un ensemble de normes, de juger des régimes politiques passés et présents. II critique les droits de l'homme en tant qu'idéologie et en tant que politique démocratique parce qu'ils ne sont pas une politique: ils mènent à l'impuissance collective et ne favorisent aucunement l'émancipation des individus. En raison de sa démarche descriptive, il n'arrive toutefois pas à formuler une politique qui permettrait à la démocratie d'avoir prise sur elle-même.
The use of mental strategies by professioal North American stage and film actors
Creators: name: Murphy, Timothy C
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2004
Subjects: subject: Psychology, Behavioral.

description: The application of sport psychology principles and theories have now moved beyond the athletic arena and branched off into non-athletic domains. Gould (2002) noted, "moving beyond the psychology of athletic excellence is an important development in our field" (p.247). Recently the mental strategies of various non-athletic domains such as musicians (Talbot-Honeck & Orlick, 1998), performing artists (Hays, 2002) and business people (Jones, 2002) have been researched and discussed. Research of actors regarding their memorization of lines (Voice, 1991; Noice, 1992; Noice & Noice, 1997), their experience of flow (Martin & Cutler, 2002), and their experience of stage fright (Steptoe et al., 1995) has been conducted, however, no research has explored the mental strategies used by professional stage and film actors. The purpose of this research has been to explore and understand the mental strategies used by professional North American actors. Twelve (n = 12) professional actors from Canada and the United States were interviewed using a semi-structured open-ended interview guide. Inductive analysis revealed that the actors used seven major mental strategies including: character preparation, focus while performing, pre-performance routines, imagery, confidence, optimal energy level, and performance evaluation. Elements of career success were also discussed. These findings shed light on specific strategies and techniques regarding the use of mental strategies by professional actors. It is hoped these findings will open the door to future research in this field and bring an understanding of relevant mental strategies for improving performance in the field of acting.
title: Mukosale B-Zellen im peripheren Blut von Patienten mit Granulomatose mit Polyangiitis als Biomarker für mukosale Organaffektionen?
Creators: name: Schaffarzyk, Annika
name: Geisen, Ulf
name: Dörr, Jonathan
name: Kaiser, Sina
name: Reid, Hayley
name: Laudien, Martin
name: Hoyer, Bimba F.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die Granulomatose mit Polyangiitis (GPA) ist eine Vaskulitis der kleinen und mittleren Gefäße, die sich im lokalisierten Erststadium zunächst als Entzündung im oberen Respirationstrakt zeigt. B-Zellen spielen in der Pathogenese eine Rolle, indem sie Autoantikörper[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
The "illusion of inclusion"? The role of consultation processes in Canadian sport policy-making
Creators: name: Comeau, Gina Sandra
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Business Administration, Sports Management.
subject: Political Science, General.

description: This dissertation addresses the role of broad-based consultation processes in sport policy formulation using a primarily neo-institutional framework. Specifically, I examine the three factors influencing participation: contextual, institutional and structural forces on consultation. The contextual factors encourage the State to develop institutional mechanisms, such as consultation. Despite these pressures to be more inclusive, the State retains control of the structural factors and the institutional factors to a lesser extent. In the case of the formulation of the Canadian sport policy, the role of these factors led to a consultation process that had a real but limited impact. This thesis contributes to the literature on two levels: theoretical and empirical. Theoretically, it develops a framework to determine the role of broad-based consultation. Empirically, it generates new knowledge of these processes and sport policy formulation in general. It demonstrates how the governance framework is useful in explaining the contextual factors encouraging the development of consultation processes. In combination with the neo-institutional literature, it outlines additional factors influencing sport policy formulation (intergovernmental relations, institutionalized relations and ideas). The research argues that these have the capacity to constrain/enable participation. Finally, it also argues that while the State is influenced by the contextual forces and institutional factors flowing through policy formation; it retains control of a number of structural factors (such as information, interaction/dialogue, stage in the policy process, and the list of participants) at its disposal enhancing its capacity to influence the process. The research findings indicate that broad-based consultation processes influence sport policy formulation, albeit very incrementally. This led to a real but limited impact. It demonstrates how the federal government was able to use consultation as a tool to obtain buy-in from governmental and non-governmental stakeholders in the sport policy sector. Even though the impact was limited, it was real nonetheless. It also provided a unique opportunity for participants to interact in a setting which included an interesting mix of participants which was quite novel for the sport policy sector.
title: Einfluss einer autologen Stammzelltransplantation auf funktionelle Autoantikörper gegen den Angiotensin Typ 1 Rezeptor bei Patienten mit progressiver systemischer Sklerodermie
Creators: name: Bankamp, Lukas
name: Preuß, Beate
name: Pecher, Ann-Christin
name: Vogel, Wichard
name: Henes, Jörg
name: Klein, Reinhild
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Bei der progressiven systemischen Sklerodermie (pSS), einer Autoimmunerkrankung mit Fibrose und Sklerose des Hautbindegewebes und Beteiligung innerer Organe, kommen verschiedene Autoantikörper (Aak) vor, wie z.B. Aak gegen TopoisomeraseI, Zentromere, RNA polymerase oder Fibrillarin.[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Status of small-scale water supplies in the WHO European Region. Results of a survey conducted under the Protocol on Water and Health
Creators: name: Rickert, Bettina
name: Samwel, Margriet
name: Shinee, Enkhtsetseg
name: Schmoll, Oliver
name: Kozisek, Frantisek
Publisher: name: World Health Organization. Regional Office for Europe
Year: 2016
Subjects: Wasserversorgung
Trinkwasser
Europa

description: Small-scale systems are an important component of water supplies in the WHO European Region. To improve the evidence base on small-scale water supplies and to gain a better overview of the status quo throughout the Region, the WHO Regional Office for Europe and the United Nations Economic Commission for Europe made a survey requesting country-specific information in 2012-2013 under the Protocol on Water and Health to the 1992 Convention on the Protection and Use of Transboundary Watercourses and International Lakes. The survey had a high response rate (81%), and this analysis of the results includes responses from 43 of the 53 countries in the WHO European Region.
This report summarizes the findings of the survey, which showed that about 23% of the population of the Region receive their drinking-water from small-scale systems. The results reveal that comprehensive information on small-scale water supplies is typically not readily available at the national level across the Region, which hampers systematic assessment of the prevailing conditions. Establishing national registers of small-scale water supplies and routine data collection mechanisms would improve the evidence base and thus support the prioritization of improvements. The findings of the assessment are intended to inform policy-making and the formulation of intervention strategies and to help identify further action under the Protocol.
Quelle: http://www.euro.who.int
A qualitative study of feminist therapy in Kingston's prison for women.
Creators: name: Balfour, Gillian C.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1994
Subjects: subject: Women's Studies.

description: The Canadian government's Task Force Report on Federally Sentenced Women, Creating Choices (1990), presents a clear mandate for correctional reforms that provide women-centred therapeutic programming to address the issues of women's exploitation and abuse. This shift in correctional policy away from the traditional sexist and neglectful models of previous government reports is the result of a collective effort of women's groups and community services as well as the voices of the prisoners interviewed from across Canada. How have the experiences of federally sentenced women and the principles and strategies of feminist therapy emerging from the shelters for battered women and victims of sexual violence transcended the prison context? This qualitative study of five feminist counsellors in the Prison for Women discusses their analytic frameworks, principles, and strategies for working with federally sentenced women in an institutional setting. An important concern is the impact of the prison setting on the strategies of feminist therapists. As clinically trained professionals who share a feminist ideology, the therapists have created an expert discourse on the impact of childhood sexual and physical abuse upon women's behaviour. The respondents accounts of the lives of federally sentenced women reconstruct their mental health "needs" and justify their behaviour in the context of victimization.
title: The importance of using 2013 ACR/EULAR classification criteria for systemic sclerosis in patients with associated pulmonary arterial hypertension
Creators: name: Yudkina, Natalia
name: Volkov, Alexander
name: Nikolaeva, Ekaterina
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: The most severe course and extremely unfavorable prognosis are patients with pulmonary arterial hypertension (PAH) associated with systemic sclerosis (PAH-SSс). SSc in a group of patients with PAH-SSс is diagnosed late, therapy is appointed untimely, which has a significant[for full text, please go to the a.m. URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
New Wark vectors
Creators: name: Tofts, Darren
Publisher: name: Swinburne
Year: 2024

description: He was the young turk of Australian cultural studies in the 1980s and an architect of the emerging cyberscene of the 90s. He gave us a lexicon of key terms that shaped our understanding of the last 20 years. Like other notable Australian expats before him (Robert Hughes, Peter Carey), McKenzie Wark has settled in New York City, where he lives with his wife, the actor and writer Christen Clifford, and their son, Felix. Wark refers to himself as a New Yorker, but is quick to add that his roots (or should that be aerials) are still very much in Australia. His moniker has been notably absent from Australian literary pages in recent years and I caught up with him where he can always be found, on the net, to see what he has been up to.
title: DFS70-Antikörper in klinischem Setting
Creators: name: Gebhardt, Christina
name: Schulze-Koops, Hendrik
name: Skapenko, Alla
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Antinukleäre Antikörper (ANA) mit dicht-feingranulärer Fluoreszenz gegen das 70kD Autoantigen (DFS70-AK) scheinen nach aktuellem Kenntnisstand nicht mit Kollagenosen assoziiert zu sein und können daher bei vorliegenden ANA ohne Nachweis von ANA gegen krankheitsassoziierte[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
title: Systemic Lupus Erythematodes ExerciseProgram (SLEEP-Studie)
Creators: name: Boedecker, Simone Cosima
name: Neuberger, Elmo
name: Philippi, Keito
name: Weinmann, Arndt
name: Schwarting, Andreas
name: Simon, Perikles
name: Weinmann-Menke, Julia
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Die SLEEP-Studie untersucht den Effekt der internetbasierten Bewegungstherapie im Vergleich zu einer Kontrollgruppe mit TAU-Therapie (Treatment as usual) beim SLE, um den Effekt regelmäßiger körperlicher Aktivität auf die Muskelentwicklung in Bezug auf die fortschreitende[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Luftqualität in der Stadt - gemeinsam weiterdenken
Creators: name: Degreif, Stefanie
name: Minnich, Lukas
name: Fischer, Heidrun
Publisher: name: Umweltbundesamt
Year: 2022
Subjects: subject: Fachplanung
subject: Stadtplanung
subject: Luftreinhalteplanung
subject: Luftreinhaltung
subject: Umweltfachplanung
subject: Koordination
subject: Integration
subject: Luft
subject: Verkehr
subject: Lärm

description: Umweltbezogene Fachplanungen wie die Luftreinhalteplanung, die Lärmaktionsplanung, die Landschaftsplanung, die Verkehrsplanung oder die Klimaanpassungsplanung haben zahlreiche Überscheidungspunkte. In der Praxis werden die unterschiedlichen Planungen jedoch oft unabhängig voneinander erarbeitet, obwohl sich durch eine bessere Integration in vielen Fällen Synergieeffekte ergäben. Das F&E-Vorhaben "Koordination und Integration von Umweltfachplanungen" hat deshalb untersucht, wie sich die umweltbezogenen Planungen besser vernetzen lassen und welche Hindernisse für eine verbesserte Koordination und Integration in der Praxis bestehen und hat konkrete Handlungsempfehlungen für ein besseres Zusammenwirken der Planungen entwickelt. Die Fachbroschüre fasst die wichtigsten Forschungsergebnisse zusammen. Quelle: www.umweltbundesamt.de
description: Umweltbezogene Fachplanungen wie die Luftreinhalteplanung, die Lärmaktionsplanung, die Landschaftsplanung, die Verkehrsplanung oder die Klimaanpassungsplanung haben zahlreiche Überscheidungspunkte. In der Praxis werden die unterschiedlichen Planungen jedoch oft unabhängig voneinander erarbeitet, obwohl sich durch eine bessere Integration in vielen Fällen Synergieeffekte ergäben.Das F&E-Vorhaben "Koordination und Integration von Umweltfachplanungen" hat deshalb untersucht, wie sich die umweltbezogenen Planungen besser vernetzen lassen und welche Hindernisse für eine verbesserte Koordination und Integration in der Praxis bestehen und hat konkrete Handlungsempfehlungen für ein besseres Zusammenwirken der Planungen entwickelt. Die Fachbroschüre fasst die wichtigsten Forschungsergebnisse zusammen.
Accelerating the digital researcher on the information superhighway
Creators: name: Sterling, Leon
Publisher: name: Swinburne
Year: 2024

description: The internet has grown over the past 50 years from a network connecting computer science researchers funded by the US military, to a network connecting two billion people worldwide. Internet users span all ages, abilities and interests, and the web has equally transformed the world for scientists and researchers. We can tackle problems with a scale and speed previously impossible. Universities and government are ensuring that the internet's possibilities for transforming the way we work are made available for large-scale research of a global, collaborative nature. The current focus on supporting the use of the internet to facilitate big science started 10 years ago in the UK with advocacy for eScience---the 'e' standing for 'enabling' rather than 'electronic'. In Australia, the term was generalised to 'eResearch' five years ago to cover the complete spectrum of research, including humanities, social sciences, medicine and all branches of science.
title: Einfluss verschiedener rheumatischer Erkrankungen auf Frühgeburtlichkeit
Creators: name: Bacher, Johanna
name: Pecher, Ann-Christin
name: Abele, Harald
name: Henes, Jörg
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: Mit dem Thema Kinderwunsch und Schwangerschaft bei rheumatischen Erkrankungen werden wir im Alltag häufig konfrontiert, da viele unserer Patienten jung erkranken und die Therapien sich in den letzten Jahren deutlich verbesserten. Ziel dieser Arbeit war es zu untersuchen, ob Kollagenosen,[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Human herpesvirus-6-induced cytokines and lymphocyte anergy.
Creators: name: Nowak, Monika.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Biology, Microbiology.

description: Human Herpesvirus-6 (HHV-6) is a lymphotropic $\beta$-herpesvirus. Epidemiological studies have shown it to be a major etiologic agent of roseola infantum. HHV-6 has been linked to several illnesses and is also considered an important cofactor in AIDS. Although HHV-6 infects a variety of cells in vivo and in vitro, complete viral replication occurs most efficiently in T lymphocytes. Following primary infection, HHV-6 persists in a latent state and can be reactivated under conditions of acquired or induced immunosuppression. The nature of HHV-6 immunosuppression remains unresolved. To address this, the cytokine repertoire expressed by T cells following HHV-6 infection and the T cell anergy induced by HHV-6 were studied. Results show that HHV-6 infected T cells secreted increased amounts of IL-1$\beta$, IL-6, IL-10, IFN-$\gamma$ and TNF-$\alpha$ when compared to mock-infected T cells. The enhanced cytokine release was mediated by binding of the virus to cells and did not require viral replication. HHV-6 exposed T cells showed a significant impairment in their proliferative response to mitogen as well as to activation signals delivered through surface molecules or other transmembrane pathways. Some virus transcription was required to suppress lymphocyte proliferation. HHV-6 infected T cells express a soluble suppressive factor(s) which inhibits the lymphoproliferative response of uninfected cells. The suppressive factor requires its native conformation for activity and its suppressive activity is reduced when neutralized with anti-HHV-6 serum. NK cytolysis in PBMCs exposed to the suppressor factor could be enhanced by the addition of IL-15. These results suggest a mechanism whereby the immune system may respond to acute immunosupvressive HHV-6 infection.
title: Therapeutic potentials of bilateral sacroiliac joint (SIJ) injection in lumbar disc prolapse: a prospective study
Creators: name: Elsaman, Ahmed
name: Radwan, Ahmed
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: Low back pain prevalence ranges from 15-30% at a certain point of lifetime to 60-80 % in whole lifetime. It is one of the commonest health problems, and considered as the second cause of pain. Disc herniation/prolapse is a major source of low back pain. SIJ dysfunctions [for full text, please go to the a.m. URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
ApoA-I deficiency increases cortical amyloid deposition, cerebral amyloid angiopathy, cortical and hippocampal astrogliosis, and amyloid-associated astrocyte reactivity in APP/PS1 mice
Creators: name: Button, Emily B.
name: Boyce, Guilaine K.
name: Wilkinson, Anna
name: Stukas, Sophie
name: Hayat, Arooj
name: Fan, Jianjia
name: Wadsworth, Brennan J.
name: Robert, Jerome
name: Martens, Kris M.
name: Wellington, Cheryl L.
Publisher: name: BioMed Central
Year: 2019

description: Background: Alzheimer’s disease (AD) is defined by amyloid beta (Aβ) plaques and neurofibrillary tangles and characterized by neurodegeneration and memory loss. The majority of AD patients also have Aβ deposition in cerebral vessels known as cerebral amyloid angiopathy (CAA), microhemorrhages, and vascular co-morbidities, suggesting that cerebrovascular dysfunction contributes to AD etiology. Promoting cerebrovascular resilience may therefore be a promising therapeutic or preventative strategy for AD. Plasma high-density lipoproteins (HDL) have several vasoprotective functions and are associated with reduced AD risk in some epidemiological studies and with reduced Aβ deposition and Aβ-induced inflammation in 3D engineered human cerebral vessels. In mice, deficiency of apoA-I, the primary protein component of HDL, increases CAA and cognitive dysfunction, whereas overexpression of apoA-I from its native promoter in liver and intestine has the opposite effect and lessens neuroinflammation. Similarly, acute peripheral administration of HDL reduces soluble Aβ pools in the brain and some studies have observed reduced CAA as well. Here, we expand upon the known effects of plasma HDL in mouse models and in vitro 3D artery models to investigate the interaction of amyloid, astrocytes, and HDL on the cerebrovasculature in APP/PS1 mice. Methods: APP/PS1 mice deficient or hemizygous for Apoa1 were aged to 12 months. Plasma lipids, amyloid plaque deposition, Aβ protein levels, protein and mRNA markers of neuroinflammation, and astrogliosis were assessed using ELISA, qRT-PCR, and immunofluorescence. Contextual and cued fear conditioning were used to assess behavior. Results: In APP/PS1 mice, complete apoA-I deficiency increased total and vascular Aβ deposition in the cortex but not the hippocampus compared to APP/PS1 littermate controls hemizygous for apoA-I. Markers of both general and vascular neuroinflammation, including Il1b mRNA, ICAM-1 protein, PDGFRβ protein, and GFAP protein, were elevated in apoA-I-deficient APP/PS1 mice. Additionally, apoA-I-deficient APP/PS1 mice had elevated levels of vascular-associated ICAM-1 in the cortex and hippocampus and vascular-associated GFAP in the cortex. A striking observation was that astrocytes associated with cerebral vessels laden with Aβ or associated with Aβ plaques showed increased reactivity in APP/PS1 mice lacking apoA-I. No behavioral changes were observed. Conclusions: ApoA-I-containing HDL can reduce amyloid pathology and astrocyte reactivity to parenchymal and vascular amyloid in APP/PS1 mice.
May Cox: leading swimming and lifesaving advocate and patriotic fundraiser
Creators: name: Towns, Deborah
Publisher: name: Swinburne
Year: 2024

description: May Cox was a swimming teacher in government schools and a highly visible community leader in Victoria in the early twentieth century. As a result of her enterprise and organisational skills thousands of children learned swimming and lifesaving. Her patriotic leadership during World War I ensured that hundreds of pounds were raised by the Education Department of Victoria and countless soldiers' comforts were provided for the Australian Red Cross.
title: Oral health-related quality of life in individuals with rheumatic diseases – a cross-sectional study
Creators: name: Patschan, Susann
name: Schmalz, Gerhard
name: Patschan, Daniel
name: Schmickler, Jan
name: Müller, Gerhard Anton
name: Ziebolz, Dirk
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: Autoimmune-mediated rheumatic disease have been documented to affect the oral health of respective patients. We therefore aimed to investigate oral health-related quality of life (OHRQoL) of patients with different rheumatic diseases. Methods: The study was cross-sectional in nature.[for full text, please go to the a.m. URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Tumor suppression of the DU 145 prostate cancer cell line: Implication of chromosomes 8 and 12.
Creators: name: Bérubé, Nathalie Guylaine.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1996
Subjects: subject: Biology, Molecular.

description: Tumorigenesis results from the accumulation of genetic events which give rise to inappropriate behaviour of cells. Mutations which lead to cancer progression are generally classified in two major categories, that of oncogenes and tumor suppressor genes. The latter have been more difficult to identify due to their recessive nature. The application of somatic cell fusion and microcell fusion technologies presents a means to identify genes inactivated in tumor cells. We have used these methodologies to identify specific chromosomes that, once introduced into the DU 145 prostate cancer cell line, have the ability to suppress tumorigenicity. Chromosomes 8 and 12 were shown to encode tumor suppressor genes inactivated in this prostate cancer cell line. To isolate the tumor suppressor gene encoded on chromosome 12, a smaller candidate region was identified by the use of radiation hybrid technology. Molecular methods subsequently led to the identification of chromosome 12 genes displaying increased expression in suppressed hybrids compared to tumorigenic hybrids. Novel genes and genes encoded by other chromosomes also demonstrated increased expression. We suggest that these genes are involved in the cellular pathway that leads to suppression in DU 145 prostate cancer cells upon the introduction of chromosome 12. Further analysis of the genes isolated in this study have the potential to serve as prognostic markers of prostate carcinogenesis.
Rebels with a cause
Creators: name: Costar, Brian
name: Curtin, Jennifer
Publisher: name: Swinburne
Year: 2024

description: The election of a minority federal government in 2010 threw the spotlight on the quiet rise of a generation of independent MPs in state and federal parliaments. In this article first published in August 2010, Brian Costar and Jennifer Curtin look at their motivations, role and significance.
title: Knochenbildgebung in einer neuen Dimension – Anwendung der Virtuellen Realität als moderne Technologie für den Wissenstransfer in der Rheumatologie
Creators: name: Kleyer, Arnd
name: Simon, David
name: Klemm, Philipp
name: Pachowsky, Milena
name: Schuster, Louis
name: Steiger, Florian
name: Hartmann, Fabian
name: Sewerin, Philipp
name: Mucke, Johanna
name: Pfeil, Alexander
name: Knitza, Johannes
name: Hueber, Axel
name: Schett, Georg
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Einleitung: CT-generierte Bilder eignen sich ideal für die dreidimensionale Visualisierung von arthritischem Knochen [ref:1]. Innovative Virtual-Reality (VR)-Anwendungen nutzen immersive Effekte, die helfen könnten, die Auswirkungen chronischer Entzündungen auf den Knochen besser[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)
Comparison of transient interfacial tension behaviours of oil/alkaline systems as measured by the drop volume and spinning drop tensiometers.
Creators: name: Ball, Sheila D.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1995
Subjects: subject: Engineering, Chemical.

description: The measurement of interfacial tension (IFT) as a function of time is useful for the study of reactions occurring at an interface. Reactions of particular importance occur in enhanced oil recovery (EOR) processes using alkaline flooding agents, in which injected alkaline solutions react with acidic oil trapped in the reservoir. In order to select the most effective alkaline agents available, an accurate method of measuring transient IFT is required. In this study, two methods of measuring the transient IFT have been examined. A relatively new method which uses an instrument called the drop volume tensiometer (DVT) has been studied. The results from this instrument have been compared to those obtained by the spinning drop tensiometer (SDT), which is the instrument most frequently used for studying transient IFT values. Interfacial tensions between oil and alkaline solutions were measured using the drop volume tensiometer and compared to those measured using the spinning drop tensiometer. The trend observed for the IFT as time progressed was surprisingly similar in both cases. However, the SDT values exhibited an increase in IFT after a minimum was reached whereas the DVT values did not generally exhibit this increase. The SDT appears to still be the preferred method for monitoring ultraflow IFT values (0.1 mN/m) as a function of time. However, it cannot be used to measure the IFT at the moment the oil droplet is created nor in the first 30 seconds once the two phases come into contact. In contrast, the DVT can only detect IFT at one discrete time. In addition, the DVT appeared to be able to measure IFT values below the manufacturer's stated lower limit of 0.2 mN/m, when employing highly viscous solutions, but was imprecise below this threshold level for solutions of lower viscosity. (Abstract shortened by UMI.)
Synthesis of a C-linked antifreeze glycoprotein building block containing an internal olefin
Creators: name: Rana, Tahir
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Chemistry, Biochemistry.

description: Antifreeze glycoproteins (AFGPs) are polypeptide compounds found in the blood of Antarctic notothenioids and northern cod. These substances inhibit the growth and proliferation of ice in fish inhabiting sub-zero conditions. The structure of AFGPs, and the mechanism of ice growth inhibition at the molecular level have been a source of intense debate. Work in our laboratory involves the synthesis of AFGP analogues in an effort to discern the mechanism of ice growth inhibition and enhance antifreeze attributes for potential therapeutic applications. We have previously synthesized C-linked AFGP analogues possessing antifreeze properties (TH, RI and DIS). One such analogue, [OGG] 4[Gal], has exhibited recrystallization inhibition (RI) activity comparable to native AFGPs. An important structural feature of [OGG]4[Gal] is the presence of an amide bond. We report herein the synthesis of a C-linked AFGP building block with an internal olefin as an amide isostere, in an effort to elucidate the function of the amide bond in the recrystallization inhibition activity of [OGG]4[Gal].
title: Perception of the value of drugs on different manifestations of psoriatic arthritis based on a multi-stage expert opinion survey
Creators: name: Oberwahrenbrock, Timm
name: Tian, Hannah
name: Thaci, Diamant
name: Krüger, Klaus
name: Wollenhaupt, Jürgen
name: Köhm, Michaela
name: Behrens, Frank
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: Patients with psoriatic arthritis (PsA) present with heterogeneous clinical phenotypes, which includes different clinical manifestations such as peripheral arthritis, axial disease, dactylitis, enthesitis, and skin and nail psoriasis. Many drugs for treatment of PsA are available for individualised[for full text, please go to the a.m. URL]
description: Deutscher Rheumatologiekongress 2020, 48. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 34. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh)