cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity
Creators: name: Wang, Jeffrey
name: Pirrotte, Patrick
name: Zhang, Lei
name: Marcucci, Guido
name: Hu, Weidong
name: Vincent, Benjamin
name: Han, Weidong
name: Lin, Yi-Chun
name: Luo, Yun Lyna
name: Su, Rui
name: Nguyen, Le Xuan Truong
name: Chen, Jianjun
name: Gojo, Ivana
name: Shen, Binghui
name: Wang, Huafeng
name: Li, Ling
name: Sharma, Ritin
name: Zhu, Yinghui
name: He, Xin
name: Ghoda, Lucy
name: Serody, Jonathan
name: Jin, Jie
name: Li, Min
name: Zhao, Dandan
name: Zeidner, Joshua
name: Dong, Haojie
name: Chen, Wei
name: Wu, Xiwei
name: Liu, Song-Bai
name: Kuo, Ya-Huei
name: Salhotra, Amandeep
name: Luznik, Leo
Publisher: name: Springer Nature
Year: 2024

description:
Current anticancer therapies cannot eliminate all cancer cells, which hijack normal arginine methylation as a means to promote their maintenance via unknown mechanisms. Here we show that targeting protein arginine N-methyltransferase 9 (PRMT9), whose activities are elevated in blasts and leukemia stem cells (LSCs) from patients with acute myeloid leukemia (AML), eliminates disease via cancer-intrinsic mechanisms and cancer-extrinsic type I interferon (IFN)-associated immunity. PRMT9 ablation in AML cells decreased the arginine methylation of regulators of RNA translation and the DNA damage response, suppressing cell survival. Notably, PRMT9 inhibition promoted DNA damage and activated cyclic GMP-AMP synthase, which underlies the type I IFN response. Genetically activating cyclic GMP-AMP synthase in AML cells blocked leukemogenesis. We also report synergy of a PRMT9 inhibitor with anti-programmed cell death protein 1 in eradicating AML. Overall, we conclude that PRMT9 functions in survival and immune evasion of both LSCs and non-LSCs; targeting PRMT9 may represent a potential anticancer strategy.
sj-docx-5-hpq-10.1177_13591053231161065 – Supplemental material for Is all validation equal? Evaluating sensory- and emotion-focused validation in the context of experimentally induced pain
Creators: name: Eskowich, Sadie
name: Mackie, Cayley
name: Wall, Kayla M
name: Gagnon, Michelle M
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, sj-docx-5-hpq-10.1177_13591053231161065 for Is all validation equal? Evaluating sensory- and emotion-focused validation in the context of experimentally induced pain by Sadie Eskowich, Cayley Mackie, Kayla M Wall and Michelle M Gagnon in Journal of Health Psychology
Kulturgüter und Gesundheit schützen
Creators: name: Buder, Andreas
Publisher: name: Berner Fachhochschule BFH, Hochschule der Künste Bern
Year: 2024

description: Im Fachbereich Konservierung und Restaurierung stehen Gesundheit und Sicherheit kontinuierlich im Fokus. Die Studierenden befinden sich in einem Dilemma: Einerseits gilt es, Kunst- und Kulturgüter zu erhalten, andererseits müssen sie ihre eigene Gesundheit schützen. Zwei verschiedene Aspekte sind zu thematisieren: die persönliche, psychische Gesundheit während des Studiums und die Gesundheit im Arbeitsalltag sowie die eigene Arbeitssicherheit.
title: Substance use among young adults in multicultural communities: risk and resilience factors
Creators: name: Andrioti, Elena-Maria
Publisher: name: Goldsmiths, University of London
Year: 2018
Subjects: subject: Substance use, alcohol use, cannabis use, dokha use, shisha use, personality, impulsivity, self-control, religiosity, religion, cross-cultural research, UK, Lebanon, UAE, risk factors, protective factors

description: Impulsivity-related personality traits have been found to be related to increased substance use, while religiosity and spirituality have been shown to reduce substance use behaviours. This thesis aimed to study possible interactive effects of risk and resilience factors on young adult substance use behaviours in multicultural communities using samples from Western countries and the Middle East. A study of 245 UK university students found self-control to be significantly related to problematic alcohol and cannabis use. The study also identified sensation seeking and fun seeking as strong predictors of cannabis use. Some of these findings were replicated in a sample of 173 university students from Lebanon. The study found fun seeking to be significantly related to problematic alcohol use. A moderating effect of religiosity on the relationship between impulsivity and substance use behaviours was also identified. A study of 191 university students in the United Arab Emirates found urgency and lack of premeditation to be strongly related to problematic dokha use. This study also identified a moderating effect of religiosity on the relationship between impulsivity and alcohol consumption. Lastly, negative urgency was shown to be strongly related to shisha consumption in a study of 80 young adults residing in the United Arab Emirates. Religiosity was also shown to be a moderator of the relationship between impulsivity and shisha use. The cultural aspects of these findings was discussed in detail. The final study of the thesis considered how risk-taking behaviours can be associated with alcohol use among a group of young adults residing in the United Arab Emirates. These findings help to further understand cultural differences in substance use behaviours, and contribute to theoretical models of risk for substance use disorders worldwide.
Supplemental Material - Development of Raman Calibration Model Without Culture Data for In-Line Analysis of Metabolites in Cell Culture Media
Creators: name: Hara, Risa
name: Kobayashi, Wataru
name: Yamanaka, Hiroaki
name: Murayama, Kodai
name: Shimoda, Soichiro
name: Ozaki, Yukihiro
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies

description: Supplemental Material for Development of Raman Calibration Model Without Culture Data for In-Line Analysis of Metabolites in Cell Culture Media by Risa Hara, Wataru Kobayashi, Hiroaki Yamanaka, Kodai Murayama, Soichiro Shimoda, and Yukihiro Ozaki in Applied Spectroscopy
Integrating education for clinical practice change
Creators: name: Schuler, Christine L.
name: Perry, Martha
name: Sarkissian, Aliese
name: Chawla, Elizabeth M.
name: Newmeyer, Amy
name: Herbst, Lori A.
name: Barnhardt, Elizabeth W.
name: Poynter, Sue E.
name: Lannon, Carole
name: McNeal‐Trice, Kenya
Publisher: name: Wiley
Year: 2024

description:
BACKGROUND: Children with chronic medical conditions and their families have significant emotional health concerns, yet paediatricians are often ill-equipped to address these needs. The American Board of Pediatrics launched the Roadmap Project to better support emotional health as part of routine care. We present pilot work in paediatric training programmes to test educational approaches and explore lessons learned. APPROACH: Four institutions implemented Roadmap tools into their paediatric training programmes, either incorporating them into existing educational structures or embedding them into the clinical workplace. One programme utilised an existing longitudinal curriculum, and another incorporated into a block rotation. Two programmes embedded training for residents into a larger programme for the healthcare team within the clinical space, one in outpatient clinics and one in an inpatient service. EVALUATION: Evaluation strategies at each site matched the intended outcomes. Sites working within education programmes evaluated learners, demonstrating increases in resident skills and confidence on pre-/post-self-assessments. Sites embedding tools into the practice context measured changes in the clinical practice of the healthcare team. Despite variability in implementation, all approaches improved trainee skills; sites embedding education into a clinical setting saw greater changes in clinical practice. IMPLICATIONS: Our pilot provided structure yet allowed for flexibility, and all sites improved trainee skills. Engaging the entire healthcare team within practice settings appears advantageous, thus embedding education into clinical practice may be preferable to a separate education programme. Similar to outcomes found in interprofessional education (IPE), educating clinical teams together may be more impactful for cultural shifts needed for changing clinical practice.
Tillerbox: an easy-to-use tool to efficiently assess tiller density in grassland
Creators: name: Käch, Damian
name: Reidy, Beat
name: Studer, Bruno
name: Kölliker, Roland
Publisher: name: Organising Committee of the 30th General Meeting of the European Grassland Federation
Year: 2024

description: Perennial ryegrass (Lolium perenne L.) is an important grass species in temperate regions due to its high forage quality and its high productivity. To maintain this productivity over time, high persistence is key. Tiller density is a trait strongly associated with persistence and is traditionally measured by manually counting tillers in swards. Even though this method is still considered state-of-the-art, it is intensive in labour and time. Therefore, a reliable high-throughput method would be highly valuable. Here we suggest such a method to assess tiller density using images taken with a self-designed ‘Tillerbox’. The ‘Tillerbox’ is a portable, waist-high box, containing a camera, enabling both standardised conditions and measurements independent of weather conditions. An image covers approx. 1800 cm2, which is at least ten times more than what is usually covered by manual counting. This makes our method especially suitable for tiller density analysis of heterogeneous swards. The images of swards of perennial ryegrass revealed significant differences in tiller density between diploid and tetraploid cultivars, which is in line with other studies. We anticipate our method to be a valuable tool for breeders to facilitate the monitoring of persistence of ryegrass in grassland.
F. A. Höynek, Geschichte des Dekanates Siegen, Bistum Paderborn
Creators: name: Gulik, Wilhelm Van
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 20 Nr. 2 (1906): Römische Quartalschrift, Band 20, Heft 2
Transgenerationale Folgen von Fürsorge und Zwang. Studienergebnisse und Implikationen für das professionelle Handeln in der Gegenwart
Creators: name: Abraham, Andrea
Publisher: name: Schulthess
Year: 2024

description: Fürsorgerische Zwangsmassnahmen und Fremdplatzierungen haben oft lebenslange Folgen für die betroffenen Personen. Der Beitrag zeigt auf, dass diese auch die nachkommende Generation betreffen. Auf der Grundlage von biografischnarrativen Interviews verdeutlicht er, dass sich die Belastungslagen insbesondere durch innerfamiliale Tabuisierungen, Nähe-Distanz Problematiken und Gewalt manifestierten und die Nachkommen bis ins Erwachsenenalter belasten können. Die Nachkommen setzten und setzen sich auf vielfältige Weise damit auseinander, die Weitergabe in eine nächste Generation zu verhindern. Basierend auf den Studienergebnissen erläutert der Beitrag Ansätze für die Gegenwart und Möglichkeiten eines trauma-informierten, professionellen Handelns.
sj-docx-1-dst-10.1177_19322968231161320 – Supplemental material for Advanced Hybrid Closed Loop in Adult Population With Type 1 Diabetes: A Substudy From the ADAPT Randomized Controlled Trial in Users of Real-Time Continuous Glucose Monitoring
Creators: name: van den Heuvel, Tim
name: Kolassa, Ralf
name: Keuthage, Winfried
name: Kroeger, Jens
name: Ré, Roseline
name: de Portu, Simona
name: Vorrink, Linda
name: Shin, John
name: Castañeda, Javier
name: Vigersky, Robert
name: Cohen, Ohad
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: Medicine
subject: 111199 Nutrition and Dietetics not elsewhere classified

description: Supplemental material, sj-docx-1-dst-10.1177_19322968231161320 for Advanced Hybrid Closed Loop in Adult Population With Type 1 Diabetes: A Substudy From the ADAPT Randomized Controlled Trial in Users of Real-Time Continuous Glucose Monitoring by Tim van den Heuvel, Ralf Kolassa, Winfried Keuthage, Jens Kroeger, Roseline Ré, Simona de Portu, Linda Vorrink, John Shin, Javier Castañeda, Robert Vigersky and Ohad Cohen in Journal of Diabetes Science and Technology
Comprehensive analysis of MYB/MYBL1-altered pediatric-type diffuse low-grade glioma
Creators: name: Klimo, Paul
name: Sullivan, Daniel V
name: Wood, Matthew
name: Saba-Silva, Nasjla
name: Davidson, Alan
name: Li, Xiaoyu
name: Robinson, Giles W
name: Moreira, Daniel C
name: Spiller, Susan
name: Chiang, Jason
name: Wagner, Aaron S
name: Qaddoumi, Ibrahim
name: Bouldin, Thomas W
name: Devidas, Meenakshi
name: Gajjar, Amar
name: Tanaka, Ryuma
name: Job, Godwin
Publisher: name: Oxford University Press (OUP)
Year: 2024

description:
BACKGROUND: Pediatric-type diffuse low-grade gliomas (pLGG) harboring recurrent genetic alterations involving MYB or MYBL1 are closely related tumors. Detailed treatment and outcome data of large cohorts are still limited. This study aimed to comprehensively evaluate pLGG with these alterations to define optimal therapeutic strategies. METHODS: We retrospectively reviewed details of pLGG with MYB or MYBL1 alterations from patients treated or referred for pathologic review at St. Jude Children's Research Hospital. Tumor specimens were centrally reviewed, and clinical data were collated. RESULTS: Thirty-three patients (18 male; median age, 5 years) were identified. Two tumors had MYBL1 alterations; 31 had MYB alterations, MYB::QKI fusion being the most common (n = 10, 30%). Most tumors were in the cerebral hemispheres (n = 22, 67%). Two patients (6%) had metastasis at diagnosis. The median follow-up was 6.1 years. The 5-year event-free survival (EFS) rate was 81.3% ± 8.3%; the 5-year overall survival (OS) rate was 96.4% ± 4.1%. Patients receiving a near-total or gross-total resection had a 5-year EFS of 100%; those receiving a biopsy or subtotal resection had a 5-year EFS rate of 56.6% ± 15.2% (P < .01). No difference in EFS was observed based on location, histology, or molecular alterations. However, the tumors that progressed or metastasized may have distinct methylation profiles with evidence of activation of the MAPK and PI3K/AKT/mTOR pathways. CONCLUSIONS: pLGG with MYB/MYBL1 alterations have good outcomes. Our findings suggest that surgical resectability is a crucial determinant of EFS. Further characterization is required to identify optimal treatment strategies for progressive tumors.
Immunoglobulin G N-glycan markers of accelerated biological aging during chronic HIV infection
Creators: name: Landay, Alan L.
name: Haberlen, Sabina
name: Kutsch, Olaf
name: Shalygin, Sergei
name: Kossenkov, Andrew
name: Macatangay, Bernard
name: Ofotokun, Igho
name: Gross, Robert
name: Tien, Phyllis C.
name: Li, Shuk Hang
name: Langan, Susan
name: Azevedo, Joao L. L. C.
name: Hanna, David B.
name: Post, Wendy S.
name: Merenstein, Daniel
name: Yin, Xiangfan
name: Fischl, Margaret A.
name: Giron, Leila B.
name: Azadi, Parastoo
name: Rinaldo, Charles
name: Wolinsky, Steven M.
name: Jamieson, Beth D.
name: Lazar, Jason
name: Adeniji, Opeyemi S.
name: Witt, Mallory D.
name: Ding, Jianyi
name: Brown, Todd T.
name: Adimora, Adaora A.
name: Lu, David Y.
name: Kannan, Toshitha
name: Frank, Ian
name: Gange, Stephen
name: Zhang, Jinbing
name: Abdel-Mohsen, Mohamed
name: Roan, Nadia R.
name: Liu, Qin
Publisher: name: Springer Nature
Year: 2024

description:
People living with HIV (PLWH) experience increased vulnerability to premature aging and inflammation-associated comorbidities, even when HIV replication is suppressed by antiretroviral therapy (ART). However, the factors associated with this vulnerability remain uncertain. In the general population, alterations in the N-glycans on IgGs trigger inflammation and precede the onset of aging-associated diseases. Here, we investigate the IgG N-glycans in cross-sectional and longitudinal samples from 1214 women and men, living with and without HIV. PLWH exhibit an accelerated accumulation of pro-aging-associated glycan alterations and heightened expression of senescence-associated glycan-degrading enzymes compared to controls. These alterations correlate with elevated markers of inflammation and the severity of comorbidities, potentially preceding the development of such comorbidities. Mechanistically, HIV-specific antibodies glycoengineered with these alterations exhibit a reduced ability to elicit anti-HIV Fc-mediated immune activities. These findings hold potential for the development of biomarkers and tools to identify and prevent premature aging and comorbidities in PLWH.
Les exploitations forestières du Jura et du Plateau en bonne santé
Creators: name: Bürgi, Patric
name: Müller, Alexandra
name: Pauli, Bernhard
name: Burri, Roland
Publisher: name: ForêtSuisse
Year: 2024

description: Les analyses du Réseau d’exploitations forestières test (REF) de Suisse invitent à l’optimisme en ce qui concerne les exploitations forestières des régions du Jura et du Plateau. Ces dernières affichent en effet des résultats économiques réjouissants.
sj-docx-1-tct-10.1177_15330338231161141 - Supplemental material for NRF1 Regulates the Epithelial Mesenchymal Transition of Breast Cancer by Modulating ROS Homeostasis
Creators: name: Sun, Linjuan
name: Ouyang, Nan
name: Shafi, Shaheryar
name: Zhao, Rongchuan
name: Pan, Jinlin
name: Hong, Lei
name: Song, Xueyan
name: Sa, Xiaohan
name: Zhou, Yuanshuai
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: FOS: Clinical medicine
subject: 110320 Radiology and Organ Imaging
subject: Biochemistry

description: Supplemental material, sj-docx-1-tct-10.1177_15330338231161141 for NRF1 Regulates the Epithelial Mesenchymal Transition of Breast Cancer by Modulating ROS Homeostasis by Linjuan Sun, Nan Ouyang, Shaheryar Shafi, Rongchuan Zhao, Jinlin Pan, Lei Hong, Xueyan Song, Xiaohan Sa and Yuanshuai Zhou in Technology in Cancer Research & Treatment
Additional file 2 of What Tests are Used to Assess the Physical Qualities of Male, Adolescent Rugby League Players? A Systematic Review of Testing Protocols and Reported Data Across Adolescent Age Groups
Creators: name: Carron, Michael A.
name: Scanlan, Aaron T.
name: Power, Cody J.
name: Doering, Thomas M.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: Mental Health

description: Additional file 2: Table B. Modified Downs and Black checklist used to assess the methodological quality of the included studies.
Jede*r gegen jede*n oder doch ensemble
Creators: name: Heberle, Wolfram
Publisher: name: Berner Fachhochschule BFH, Hochschule der Künste Bern
Year: 2024

description: Wolfram Heberle, Studiengangsleiter HKB Theater, über den Wettbewerb in der Schauspielausbildung. Oder warum dünnhäutige Schauspieler*innen eine dicke Haut benötigen.
Rosanna Raymond on Conser.Vā.Tion: A conversation with Hanna B. Hölling, Jules Pelta Feldman, and Emilie Magnin
Creators: name: Raymond, Rosanna
name: Hölling, Hanna Barbara
name: Fledman, Jules Pelta
name: Magnin, Emilie
Publisher: name: Routledge
Year: 2024
Subjects: performance
pacific performance
Rosanna Raymond
ancestrial past
indogenous
conservation
activation
costume
colonial
archive

description: In a conversation with Hanna B. Hölling, Jules Pelta Feldman, and Emilie Magnin, artist Rosanna Raymond discusses her interest in preserving Pacific heritage through performance. As a member of the Pacific Sisters and SaVĀge K‘lub Collective, she aims to tell Pacific stories through visual storytelling that includes her body. Raymond’s upbringing in street culture, combined with her experiences in hip-hop, spoken word, and various artistic forms, has influenced her approach to making the past present and preserving Pacific heritage. Raymond’s performance practice challenges conventional museum systems and norms, focusing on making cultural practice a living and relevant part of urban life. The concept of vā, a relational space that binds people and things, is crucial to her practice, and she has found the term to be applicable across various Pacific cultures. Representing a decolonized body that shares space with the ancestral past, the ‘Vā Body’ creates a tangible experience of intangible cultural heritage. Through her work in museums, Raymond has encountered challenges in conveying the meaning of her performances to Western institutions. She believes that cultural health and safety, including setting out intentions and asking for permission from ancestors, is essential in preserving and sharing cultural heritage through performances.
El Hierro Genome Study: A Genomic and Health Study in an Isolated Canary Island Population
Creators: name: Serrano, Javier G.
name: Sullivan, Patrick F.
name: García, Elsa L.
name: Carracedo, Mario A. González
name: Pino-Yanes, María
name: Karlsson, Robert
name: Fregel, Rosa
name: Jiménez-Canino, Rubén
name: Puga, Marta
Publisher: name: MDPI
Year: 2024

description:
El Hierro is the smallest and westernmost island of the Canary Islands, whose population derives from an admixture of different ancestral components and that has been subjected to genetic isolation. We established the "El Hierro Genome Study" to characterize the health status and the genetic composition of ~10% of the current population of the island, accounting for a total of 1054 participants. Detailed demographic and clinical data and a blood sample for DNA extraction were obtained from each participant. Genomic genotyping was performed with the Global Screening Array (Illumina). The genetic composition of El Hierro was analyzed in a subset of 416 unrelated individuals by characterizing the mitochondrial DNA (mtDNA) and Y-chromosome haplogroups and performing principal component analyses (PCAs). In order to explore signatures of isolation, runs of homozygosity (ROHs) were also estimated. Among the participants, high blood pressure, hypercholesterolemia, and diabetes were the most prevalent conditions. The most common mtDNA haplogroups observed were of North African indigenous origin, while the Y-chromosome ones were mainly European. The PCA showed that the El Hierro population clusters near 1000 Genomes' European population but with a shift toward African populations. Moreover, the ROH analysis revealed some individuals with an important portion of their genomes with ROHs exceeding 400 Mb. Overall, these results confirmed that the "El Hierro Genome" cohort offers an opportunity to study the genetic basis of several diseases in an unexplored isolated population.
S. Francisci Assis,vita et miracula, additis opusculis liturgicis
Creators: name: Eubel, Konrad
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 20 Nr. 2 (1906): Römische Quartalschrift, Band 20, Heft 2
Warum Unternehmen digitale Spuren der Designarbeit sammeln wollen
Creators: name: Lueg, Christopher P.
Publisher: name: Berner Fachhochschule, Wirtschaft
Year: 2024

description: Die Design-Community ist besorgt, dass Unternehmen wie Figma die in der Cloud gespeicherten Design-Ressourcen ihrer Nutzer zum Trainieren von KI-Modellen verwenden, oft ohne deren ausdrückliche Zustimmung. Dies gefährdet die kreative Autonomie der Designer*innen, da nicht nur Daten, sondern auch ihre Arbeitsmethoden erfasst und genutzt werden. Über das Pro und Kontra schreibt unser Gastautor Christopher Lueg.
Adaptation of nutritional risk screening tools may better predict response to nutritional treatment: a secondary analysis of the randomized controlled trial Effect of early nutritional therapy on Frailty, Functional Outcomes, and Recovery of malnourished medical inpatients Trial (EFFORT).
Creators: name: Wunderle, Carla
name: Siegenthaler, Jolanda
name: Seres, David
name: Owen-Michaane, Michael
name: Tribolet, Pascal
name: Stanga, Zeno
name: Mueller, Beat
name: Schuetz, Philipp
Publisher: name: Elsevier
Year: 2024
Subjects: treatment response
polymorbid medical inpatient
personalized nutrition
nutritional risk screening
mortality
clinical outcome
nutritional support
disease-related malnutrition

description: Nutritional screening tools have proven valuable for predicting clinical outcomes but have failed to determine which patients would be most likely to benefit from nourishment interventions. The Nutritional Risk Screening 2002 (NRS) and the Mini Nutritional Assessment (MNA) are 2 of these tools, which are based on both nutritional parameters and parameters reflecting disease severity. We hypothesized that the adaptation of nutritional risk scores, by removing parameters reflecting disease severity, would improve their predictive value regarding response to a nutritional intervention while providing similar prognostic information regarding mortality at short and long terms. We reanalyzed data of 2028 patients included in the Swiss-wide multicenter, randomized controlled trial EFFORT (Effect of early nutritional therapy on Frailty, Functional Outcomes, and Recovery of malnourished medical inpatients Trial) comparing individualized nutritional support with usual care nutrition in medical inpatients. The primary endpoint was 30-d all-cause mortality. Although stratifying patients by high compared with low NRS score showed no difference in response to nutritional support, patients with high adapted NRS showed substantial benefit, whereas patients with low adapted NRS showed no survival benefit [adjusted hazard ratio: 0.55 [95% confidence interval (CI): 0.37, 0.80]] compared with 1.17 (95% CI: 0.70, 1.93), a finding that was significant in an interaction analysis [coefficient: 0.48 (95% CI: 0.25, 0.94), P = 0.031]. A similar effect regarding treatment response was found when stratifying patients on the basis of MNA compared with the adapted MNA. Regarding the prognostic performance, both original scores were slightly superior in predicting mortality than the adapted scores. Adapting the NRS and MNA by including nutritional parameters only improves their ability to predict response to a nutrition intervention, but slightly reduces their overall prognostic performance. Scores dependent on disease severity may best be considered prognostic scores, whereas nutritional risk scores not including parameters reflecting disease severity may indeed improve a more personalized treatment approach for nourishment interventions. The trial was registered at clinicaltrials.gov as NCT02517476.
"Wenn man etwas anders machen möchte, kommt es nicht so gut an" - Roundtable mit Lennart Dohms und Wojciech Chmielewski
Creators: name: Pauli, Christian
name: Dohms, Lennart
name: Chmielewski, Wojciech
name: Rod, Tim
Publisher: name: Berner Fachhochschule BFH, Hochschule der Künste Bern
Year: 2024

description: Talentshows im Klassikmarkt beeinflussen Karriere, Renommée und Akquise von jungen Musiker*innen auf der ganzen Welt. Ist Wettbewerbsdenken und Exzellenzstreben angebracht in Zeiten, in denen Zusammenhalt und Partizipation gepredigt werden? Was macht der Wettbewerb mit den freien Künsten? Was richtet Wettbewerb an Kunsthochschulen an?
sj-pdf-1-jrn-10.1177_17449871231182837 – Supplemental material for The relationship between workplace violence, emotional exhaustion, job satisfaction and turnover intention among nurses during the COVID-19 pandemic
Creators: name: Gedik, Özlem
name: Ülke Şimdi, Refika
name: Kıbrıs, Şerife
name: (Sivuk), Derya Kara
Publisher: name: SAGE Journals
Year: 2023
Subjects: Nursing not elsewhere classified
Sociological Methodology and Research Methods

description: Supplemental material, sj-pdf-1-jrn-10.1177_17449871231182837 for The relationship between workplace violence, emotional exhaustion, job satisfaction and turnover intention among nurses during the COVID-19 pandemic by Özlem Gedik, Refika Ülke Şimdi, Şerife Kıbrıs and Derya Kara (Sivuk) in Journal of Research in Nursing
Plasma H3Cit-DNA Discriminates Between Cancer and Inflammation in a Cohort of Patients with Unspecific Cancer Symptoms
Creators: name: Åberg, Mikael
name: Gordon, Max
name: Mackman, Nigel
name: Rosell, Axel
name: Thålin, Charlotte
name: Wannberg, Fredrika
name: Hjalmar, Viktoria
name: Ng, Henry
name: Probert, Fay
name: Johansson, Caroline
name: Phillipson, Mia
Publisher: name: Springer Nature
Year: 2024

description:
Cancer detection is challenging, especially in patients with unspecific cancer symptoms. Biomarkers could identify patients at high risk of cancer. Prior studies indicate that neutrophil extracellular traps (NETs) are associated with cancer, but also with autoimmune and infectious diseases. The objective of this prospective study was to investigate markers associated with NET formation (nucleosomal citrullinated histone 3 [H3Cit-DNA], cell free DNA [cfDNA] and neutrophil elastase [NE]), and c-reactive protein (CRP) in patients with unspecific cancer symptoms, such as fatigue, weight loss or radiological sign of malignancy without an apparent primary tumor, referred to the Diagnostic Center at Danderyd Hospital in Sweden. Blood samples were drawn on admission, before cancer diagnosis. Out of 475 patients, 160 (34%) were diagnosed with cancer, 56 (12%) with autoimmune disease, 32 (7%) with infectious disease, 71 (15%) with other diseases and 156 (33%) received no diagnosis. H3Cit-DNA, cfDNA, NE and CRP were significantly higher in patients with cancer compared to patients without cancer (p < 0.0001, p < 0.0001, p = 0.004, and p = 0.0002 respectively). H3Cit-DNA, but not cfDNA, NE or CRP, was significantly elevated in patients with cancer compared to patients with autoimmune disease (p = 0.0001). H3Cit-DNA, cfDNA, NE or CRP did not differ between cancer and infectious disease. In conclusion, H3Cit-DNA is elevated in patients diagnosed with cancer compared to non-cancer patients with the same symptomatology. Further studies should evaluate if H3Cit-DNA could aid in selecting patients that would benefit the most from a rapid cancer diagnostic work-up.Graphical Abstract
Mapping of Health System Performance Indicators to the WHO HSPA Framework
Creators: name: Adam, Lucien
name: Leung, Anthéa Helene
name: Sariyar, Murat
Publisher: name: IOS Press
Year: 2024
Subjects: Health system performance assessment
R Shiny App
Swiss healthcare system
health indicators

description: Healthcare systems worldwide face escalating costs and demographic changes, necessitating effective evaluation tools to understand their underlying challenges. Switzerland's high-quality yet costly healthcare system underscores the need for robust assessment methods. Existing international rankings often lack transparency and comparability, highlighting the value of structured frameworks like the Health System Performance Assessment (HSPA) by the World Health Organization (WHO). This framework evaluates healthcare systems across multiple dimensions including governance, resource generation, financing, and service delivery. This paper aims to integrate Swiss healthcare indicators from the Swiss Health Observatory (Obsan) into the HSPA framework, addressing the central research question: How can these indicators be mapped to the HSPA framework, and what insights does this integration provide? Our methodology includes selecting and categorizing Obsan indicators, manually mapping them to HSPA sub-functions, and validating these mappings using word embeddings and cosine similarity. An R Shiny application was developed for interactive visualization. Results demonstrate accurate indicator assignment, enabling intuitive visualization and enhancing data structuring.
The Digital Dilemma: Climate Threat or Enabler for Net Zero?
Creators: name: Bieser, Jan
Year: 2024

description: Amazon promises to be net zero by 2040, Google by 2030. Apple aims to be carbon neutral by 2030, and Microsoft even carbon negative. Yet, the IT sector is not aligned with global climate goals and is causing more and more CO2 emissions. In other sectors, digitalization is often seen as a climate savior. However, even though digital applications provide a large theoretical potential for emission reductions, this potential has not yet been realized. For example, digital mobility services can make public transportation more attractive and efficient, but through car- and ride-sharing, they can also increase car traffic. With the breakthrough of the Internet of Things (IoT) and Artificial Intelligence (AI), the role of digital technology in the economy and everyday life will increase even further. To ensure that the next era of digitalization does not increase environmental problems, targeted action is required. In his lecture, Jan Bieser discussed the opportunities and risks of digitalization for climate protection and pathways toward a sustainable digital society.
Vom IT-Boom zu Nachhaltigkeit: Indiens neue Herausforderungen
Creators: name: Kamath, Arvind
name: Ritley, Kenneth
Publisher: name: Berner Fachhochschule, Wirtschaft
Year: 2024

description: Der IT-Boom der frühen 2000er Jahre veränderte Indien und die Welt. Er deckte den weltweiten Bedarf an IT-Dienstleistungen, hob Millionen von Menschen aus der Armut, positionierte Indien als zentralen Knotenpunkt im weltweiten Technologienetzwerk und veränderte die Arbeitsweise der Welt. Doch zwei Jahrzehnte später brachte er eine ganz neue Reihe von Herausforderungen für die Nachhaltigkeit mit sich. Dieser Artikel beschreibt diese und wie Projekte von Sharada Educational Trust und der Berner Fachhochschule bei der Lösung helfen..
Vitamin D and Toxic Metals in Pregnancy - a Biological Perspective
Creators: name: Morisset, Anne-Sophie
name: Buckley, Jessie P.
name: Jukic, Anne Marie
name: Weiler, Hope A.
name: Potter, Beth K.
name: Fisher, Mandy
name: Kuiper, Jordan R.
name: Subramanian, Anita
name: Little, Julian
name: Ashley-Martin, Jillian
name: Arbuckle, Tye E.
name: Borghese, Michael
name: Shutt, Robin
Publisher: name: Springer Nature
Year: 2024

description:
Purpose of Review To discuss the potential biological mechanisms between vitamin D and toxic metals and summarize epidemiological studies examining this association in pregnant women.


Recent Findings We identified four plausible mechanisms whereby vitamin D and toxic metals may interact: nephrotoxicity, intestinal absorption of metals, endocrine disruption, and oxidative stress. Few studies have examined the association between vitamin D and toxic metals in pregnant women. North American studies suggest that higher vitamin D status early in pregnancy are associated with lower blood metals later in pregnancy. However, a trial of vitamin D supplementation in a pregnant population, with higher metal exposures and lower overall nutritional status, does not corroborate these findings.


Summary Given ubiquitous exposure to many toxic metals, nutritional intervention could be a means for prevention of adverse outcomes. Future prospective studies are needed to establish a causal relationship and clarify the directionality of vitamin D and metals.
Molecular NMR shieldings, J-couplings, and magnetizabilities from numeric atom-centered orbital based density-functional calculations
Creators: name: Mandzhieva, Iuliia
name: Warren, Warren S
name: Blum, Volker
name: Huhn, William P
name: Theis, Thomas
name: Laasner, Raul
name: Colell, Johannes
name: Yu, Victor Wen-zhe
Publisher: name: IOP Publishing
Year: 2024

description:
This paper reports and benchmarks a new implementation of nuclear magnetic resonance shieldings, magnetizabilities, and J-couplings for molecules within semilocal density functional theory, based on numeric atom-centered orbital (NAO) basis sets. NAO basis sets are attractive for the calculation of these nuclear magnetic resonance (NMR) parameters because NAOs provide accurate atomic orbital representations especially near the nucleus, enabling high-quality results at modest computational cost. Moreover, NAOs are readily adaptable for linear scaling methods, enabling efficient calculations of large systems. The paper has five main parts: (1) It reviews the formalism of density functional calculations of NMR parameters in one comprehensive text to make the mathematical background available in a self-contained way. (2) The paper quantifies the attainable precision of NAO basis sets for shieldings in comparison to specialized Gaussian basis sets, showing similar performance for similar basis set size. (3) The paper quantifies the precision of calculated magnetizabilities, where the NAO basis sets appear to outperform several established Gaussian basis sets of similar size. (4) The paper quantifies the precision of computed J-couplings, for which a group of customized NAO basis sets achieves precision of ∼Hz for smaller basis set sizes than some established Gaussian basis sets. (5) The paper demonstrates that the implementation is applicable to systems beyond 1000 atoms in size.
Köpfe der Forschung: Hanna B. Hölling
Creators: name: Pernet, Nathalie
name: Hölling, Hanna Barbara
Publisher: name: HKB Bern Academy of the Arts
Year: 2024
Subjects: Forschung
Biography
Hölling
Konservierung

description: Dieses Interview, geführt von Nathalie Pernet, gibt Einblicke in die Arbeit von Hanna B. Hölling, Kunstwissenschaftlerin und Konservatorin, die das Forschungsfeld Contemporary Art and Media am Institut Materialität in Kunst und Kultur der HKB koordiniert. Sie leitet die beiden SNF-Projekte «Activating Fluxus» und «Performance: Conservation, Materiality, Knowledge». Mit einer Promotion an der Universität Amsterdam und akademischen Tätigkeiten an Institutionen wie dem UCL und dem Bard Graduate Center bringt Hölling umfassende Expertise zur Materialität und Erhaltung zeitgenössischer sowie Medienkunst mit. In ihrer Forschung untersucht sie, wie sich Kunstwerke im Laufe der Zeit verändern, und hinterfragt traditionelle Vorstellungen von Beständigkeit und Vergänglichkeit. Dabei beleuchtet sie die sozialen und politischen Dimensionen der Konservierung. Zu ihren jüngsten Forschungsschwerpunkten zählen die Begriffe «Care» und «Natureculture» im Kontext der Erhaltung kultureller und natürlicher Umgebungen als Reaktion auf Klima- und humanitäre Krisen. Im Rahmen ihres Projekts zur Performance-Konservierung organisiert Hölling das Festival «Conserving Performance, Performing Conservation» im September 2024. An fünf Veranstaltungsorten in der Schweiz untersucht das Festival die Wissensvermittlung und Archivierung in der Performancekunst durch partizipative Formate und internationale Kooperationen. Eine begleitende Ausstellung an der HKB interpretiert Konservierung als aktive und kreative Kraft, die das Weiterleben von Performance neu definiert.
Improvement of fatigue in generalised myasthenia gravis with zilucoplan
Creators: name: Utsugisawa, Kimiaki
name: Bloemers, Jos
name: Howard, Emily
name: Freimer, Miriam
name: Savic, Natasa
name: Maniaol, Angelina
name: Boroojerdi, Babak
name: Weiss, Michael D.
name: Leite, M. Isabel
name: Howard, James F.
Publisher: name: Springer Nature
Year: 2024

description:
Background Fatigue is a debilitating symptom of myasthenia gravis (MG). The impact of fatigue on MG can be assessed by Quality of Life in Neurological Disorders (Neuro-QoL) Short Form Fatigue scale. Transformation of raw Neuro-QoL fatigue scores to T-scores is a known approach for facilitating clinical interpretation of clinically meaningful and fatigue severity thresholds.


Methods In the Phase 3, double-blind, placebo-controlled RAISE study (NCT04115293), adults with acetylcholine receptor autoantibody-positive generalised MG (MG Foundation of America Disease Class II–IV) were randomised 1:1 to daily subcutaneous zilucoplan 0.3 mg/kg or placebo for 12 weeks. Patients completing RAISE could opt to receive zilucoplan 0.3 mg/kg in an ongoing, open-label extension study, RAISE-XT (NCT04225871). In this post-hoc analysis, we evaluated the long-term effect of zilucoplan on fatigue in RAISE patients who entered RAISE-XT. We report change in Neuro-QoL Short Form Fatigue T-scores and fatigue severity levels from RAISE baseline to Week 60.


Results Mean Neuro-QoL Short Form Fatigue T-scores improved from baseline to Week 12 in the zilucoplan group (n = 86) with a clinically meaningful difference versus placebo (n = 88; least squares mean difference: − 3.61 (nominal p-value = 0.0060]), and these improvements continued further to Week 60. At Week 12, more patients on zilucoplan (n = 34, 47.2%) experienced improvements in ≥ 1 fatigue severity level from baseline versus placebo (n = 23, 28.4%; p = 0.017). At Week 60, most (n = 55, 65.5%) patients had mild fatigue or none.


Conclusion Treatment with zilucoplan demonstrated statistical and clinically meaningful improvements in fatigue scores and severity versus placebo during RAISE, which were sustained to Week 60 in RAISE-XT.
Deutsche in Avignon und ihre Wohnungen zur Zeit Johanns XXII. (1316-1334)
Creators: name: Schäfer, H. K.
Publisher: name: Römische Quartalschrift
Year: 1970

description: Römische Quartalschrift, Bd. 20 Nr. 2 (1906): Römische Quartalschrift, Band 20, Heft 2
Gauge-invariant optical selection rules for excitons
Creators: name: Fernando, Tharindu
Publisher: name: arXiv
Year: 2024
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Presently, the optical selection rules for excitons under circularly-polarized light are manifestly gauge-dependent. Recently, Fernando et al. introduced a gauge-invariant, quantized interband index. This index may improve the topological classification of material excited states because it is intrinsically an inter-level quantity. In this work, we expand on this index to introduce its chiral formulation, and use it to make the selection rules gauge-invariant. We anticipate this development to strengthen the theory of quantum materials, especially two-dimensional semiconductor photophysics.
The In-State Exception in Swiss Public Procurement Law: A Largely Unregulated Regulation
Creators: name: Koch, Rika
name: Lehner, Caroline
Publisher: name: Springer
Year: 2024

description: The revised Swiss Federal Act on Public Procurement, entered into force 2021, led to the codification of what is commonly referred to as “In-State” procurement: Article 10 III b excludes certain purchasing arrangements between legally separate public entities from the scope of the public procurement law. So while public procurement is usually subject to national as well as international rules on non-discrimination, competition and transparency, In-State procurement is exempted from these rules and can be awarded by public entities at their free discretion. EU law includes a similar concept, commonly referred to as “non-institutionalised exception”. However, while the 2014/24/EU Directive enumerates specific conditions that must be met to rely on this exception, the Swiss In-State provision merely states that the services in question should not be “offered in competition with private tenderers”. This article sheds light on the various criteria proposed to implement In-State procurement in practice. It then proposes an alternative, novel interpretative approach, analysing the categories of activities of public entities and their relation to the market to answer the question, whether they can be procured based on the In-State exception.
Association between Tobacco Industry Interference Index (TIII) and MPOWER measures and adult daily smoking prevalence rate in 30 countries
Creators: name: Kim, Siwoo
name: Kawachi, Ichiro
name: Kim, Min Kyung
name: Lee, Yuri
name: Oh, Juhwan
Publisher: name: Springer Nature
Year: 2024

description:
Background This study aimed to investigate the impact of tobacco industry interference on the implementation and management of tobacco control and the tobacco epidemic using the Tobacco Industry Interference Index (TIII) and MPOWER—a package of measures for tobacco control—and adult daily smoking prevalence in 30 countries.


Methods The TIII was extracted from the Global Tobacco Industry Interference Index 2019 and Global Center for Good Governance in Tobacco Control (GGTC). MPOWER measures and adult daily smoking prevalence rate were extracted from the World Health Organization (WHO) report on the global tobacco epidemic in 2021. We assessed the ecological cross-lagged association between TIII and MPOWER scores and between TIII and age-standardized prevalence rates for adult daily tobacco users.


Results Tobacco industry interference was inversely correlated with a country’s package of tobacco control measures (β = -0.088, P = 0.035). The TIII was correlated with weaker warnings about the dangers of tobacco (β = -0.016, P = 0.078) and lack of enforcement of bans on tobacco advertising promotion and sponsorship (β = -0.023, P = 0.026). In turn, the higher the TIII, the higher the age-standardized prevalence of adult daily tobacco smokers for both sexes (β = 0.170, P = 0.036). Adult daily smoking prevalence in males (β = 0.417, P = 0.004) was higher in countries where the tobacco industry received incentives that benefited its business.


Conclusion Where the interference of the tobacco industries was high, national compliance with the Framework Convention on Tobacco Control (FCTC) was lower, and the prevalence of adult daily smokers higher. National governments and global society must work together to minimize the tobacco industry’s efforts to interfere with tobacco control policies.
Functioning and quality of life among treatment-engaged adults with psychotic disorders in urban Tanzania: Baseline results from the KUPAA clinical trial
Creators: name: Clari, Rosarito
name: Headley, Jennifer
name: Swai, Praxeda
name: Dixon, Lisa
name: Egger, Joseph R.
name: Kaaya, Sylvia
name: Ndelwa, Liness
name: Baumgartner, Joy Noel
name: Lukens, Ellen
name: Lawala, Paul
name: Temu, Joseph
name: Martinez, Alyssa
name: Bukuku, Eliasa Swata
name: Susser, Ezra
name: Minja, Anna
Publisher: name: Public Library of Science (PLoS)
Year: 2024

description:
BACKGROUND: There is a treatment gap for those living with severe mental illnesses in low- and middle-income countries, yet not enough is known about those who are currently accessing clinical services. A better understanding of potentially modifiable factors associated with functioning and quality of life will help inform policies and programming. AIMS: To describe the functioning and quality of life for a psychiatric treatment-engaged population living with psychotic disorders in two urban areas of Tanzania, and to explore their respective correlates. METHODS: This study analyzed cross-sectional data from 66 individuals enrolled in the Kuwezeshana Kupata Uzima (KUPAA) pilot clinical trial who had a diagnosis of schizophrenia or schizoaffective disorder, recent relapse, and who were receiving outpatient treatment. Baseline functioning (WHO Disability Assessment Schedule 2.0) and quality of life (WHO Quality of Life BREF scale) were measured. Univariable and multivariable regression analyses were conducted to determine correlates of functioning and quality of life. RESULTS: Adjusted analyses indicated that higher disability was associated with higher food insecurity, more symptomatology, more self-stigma, less instrumental support, less hope, lower self-efficacy, and/or lower levels of family functioning. Higher quality of life was associated with higher levels of self-efficacy, more hopefulness, more instrumental support, less self-stigma, and better family functioning. CONCLUSIONS: Identification of factors associated with disability and quality of life can help clinicians and policymakers, as well as consumers of mental health services, to better co-design and target psychosocial interventions to optimize their impact in low-resource settings. TRIAL REGISTRATION: Trial registration: ClinicalTrials.gov # NCT04013932, July 10, 2019.