cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Production of light nuclei and anti-nuclei in pp and Pb-Pb collisions at LHC energies
Creators: name: ALICE Collaboration
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: The production of (anti-)deuteron and (anti-)$^{3}$He nuclei in Pb-Pb collisions at $\sqrt{s_{\rm NN}}$ = 2.76 TeV has been studied using the ALICE detector at the LHC. The spectra exhibit a significant hardening with increasing centrality. Combined blast-wave fits of several particles support the interpretation that this behavior is caused by an increase of radial flow. The integrated particle yields are discussed in the context of coalescence and thermal-statistical model expectations. The particle ratios, $^3$He/d and $^3$He/p, in Pb-Pb collisions are found to be in agreement with a common chemical freeze-out temperature of $T_{\rm chem} \approx 156$ MeV. These ratios do not vary with centrality which is in agreement with the thermal-statistical model. In a coalescence approach, it excludes models in which nucleus production is proportional to the particle multiplicity and favors those in which it is proportional to the particle density instead. In addition, the observation of 31 anti-tritons in Pb-Pb collisions is reported. For comparison, the deuteron spectrum in pp collisions at $\sqrt{s} = 7$ TeV is also presented. While the p/$π$ ratio is similar in pp and Pb-Pb collisions, the d/p ratio in pp collisions is found to be lower by a factor of 2.2 than in Pb-Pb collisions.
description: 32 figures, 18 captioned figures, 3 tables, authors from page 27, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/1685
Transforming growth factor beta mediates hepatocyte apoptosis through Smad3 generation of reactive oxygen species
Creators: name: Rippe, Richard A.
name: Lemasters, John J.
name: Qian, Ting
name: Behrns, Kevin E.
name: Black, Dalliah
name: Kim, Jae Sung
name: Lyman, Suzanne
name: Nitta, Takashi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: TGFβ induces hepatocyte apoptosis via reactive oxygen species (ROS) generation, the mitochondrial permeability transition (MPT), and caspase activation. The role of the Smad pathway in these events is unknown. In this study primary hepatocytes were isolated from Smad3 wild-type (+/+) and knockout (−/−) mice, and were treated with TGFβ (5 ng/ml) and/or trolox (2 mM). ROS generation, MPT, TGFβ-dependent transcription, and apoptosis were assessed in the presence or absence of Smad3 wild-type (WT) and dominant-negative (DN) plasmids. With TGFβ treatment, Smad3 (−/−) hepatocytes did not generate ROS activity, exhibit MPT, activate caspases, or undergo apoptosis when compared to Smad 3 (+/+) hepatocytes. Similarly, transfection of Smad3 (+/+) hepatocytes with DN-Smad3 inhibited TGFβ-mediated transcription, ROS generation, MPT, and apoptosis. However, Smad3 (−/−) cells transfected with WT-Smad3 and treated with TGFβ demonstrated increased transcriptional activity, the MPT, and TGFβ-induced apoptosis. TGFβ-mediated ROS generation occurred through an NADPH–like oxidase pathway since diphenyleneiodonium chloride inhibited ROS induction. In conclusion, TGFβ-induced hepatocyte apoptosis occurs through Smad3 dependent activation of ROS with subsequent activation of the MPT and caspases.
title: Особенности преподавания дисциплины «Цветоведение и колористика» будущим графическим дизайнерам
Creators: name: ELS IPR BOOKS
Publisher: name: Южно-Уральский технологический университет
Year: 2021

description: Настоящее пособие предназначено для обучающихся по направлению подготовки 54.03.01 Дизайн для очной и заочной форм обучения Направленность (профиль) образовательной программы «Графический дизайн». Учебное пособие отражает современное состояние курса «Цветоведение и колористика». Рассматриваются вопросы конструирования цветовой композиции. Цветоведение и колористика, обращается к эстетическим характеристикам цвета, гармонии цветовых отношений, красоте колорита в картине. Компетентность в области конструирования цветовых композиций эффективно формируется при развитии гармоничности мышления (на основе изучения теории о гармонии) и закреплении на практике путей приведения цветовых отношений в гармонию (профессиональной деятельности). Взаимосвязь интуиции и научного подхода в художественном творчестве обеспечивается через систематическое развитие образно-творческих способностей, чувства гармонии и освоение понятий о гармонии и ее признаках. Основные признаки гармонии: цельность, единство противоположностей, пропорциональность, равновесие, устойчивость. Творческие способности включают: способность познавать, обогащать свое творчество знаниями того, что уже создано человечеством, опытом творческой деятельности, и способность выйти за рамки привычных способов деятельности, готовность к открытию нового, неизвестного.
title: Цветоведение и колористика
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2022

description: В учебном пособии рассмотрены вопросы конструирования цветовой композиции на основе принципов и видов гармонии. Изложены основы цветовой индукции, контраста взаимодополнительных цветов, смешения цветов. Отдельная глава посвящена формированию цветового дискурса. Учебное пособие предназначено для изучения дисциплины «Цветоведение» по укрупненной группе специальностей и профессий среднего профессионального образования 54.00.00 «Изобразительное и прикладные виды искусств».
Sparse Grid Discontinuous Galerkin Methods for High-Dimensional Elliptic Equations
Creators: name: Wang, Zixuan
name: Tang, Qi
name: Guo, Wei
name: Cheng, Yingda
Publisher: name: arXiv
Year: 2015
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: This paper constitutes our initial effort in developing sparse grid discontinuous Galerkin (DG) methods for high-dimensional partial differential equations (PDEs). Over the past few decades, DG methods have gained popularity in many applications due to their distinctive features. However, they are often deemed too costly because of the large number of degrees of freedom of the approximation space, which are the main bottleneck for simulations in high dimensions. In this paper, we develop sparse grid DG methods for elliptic equations with the aim of breaking the \emph{curse of dimensionality}. Using a hierarchical basis representation, we construct a sparse finite element approximation space, reducing the degrees of freedom from the standard {$O(h^{-d})$ to $O(h^{-1}|\log_2 h|^{d-1})$} for $d$-dimensional problems, where $h$ is the uniform mesh size in each dimension. Our method, based on the interior penalty (IP) DG framework, can achieve accuracy of $O(h^{k}|\log_2 h|^{d-1})$ in the energy norm, where $k$ is the degree of polynomials used. Error estimates are provided and confirmed by numerical tests in multi-dimensions.
Antiparasitic compounds that target DNA
Creators: name: Mathis, Amanda
name: Hall, James Edwin
name: Wilson, W. David
name: Tanious, Farial A.
name: Tevis, Denise
name: Boykin, David W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Designed, synthetic heterocyclic diamidines have excellent activity against eukaryotic parasites that cause diseases such as sleeping sickness and leishmania and adversely affect millions of people each year. The most active compounds bind specifically and strongly in the DNA minor groove at AT sequences. The compounds enter parasite cells rapidly and appear first in the kinetoplast that contains the mitochondrial DNA of the parasite. With time the compounds are also generally seen in the cell nucleus but are not significantly observed in the cytoplasm. The kinetoplast decays over time and disappears from the mitochondria of treated cells. At this point the compounds begin to be observed in other regions of the cell, such as the acidocalcisomes. The cells typically die in 24–48 hours after treatment. Active compounds appear to selectively target extended AT sequences and induce changes in kinetoplast DNA minicircles that cause a synergistic destruction of the catenated kinetoplast DNA network and cell death.
Characterization of endogenous and recombinant human calpain-10
Creators: name: Dong, Biao
name: Liu, Rihe
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Calpain-10 is a novel ubiquitous calpain family member that has been implicated as a susceptibility gene for type 2 diabetes. One of the major challenges is that the biochemical function of calpain-10 is not yet known. To address the problem, we purified human calpain-10 from different sources, including the endogenous and the recombinant calpain-10 from HeLa S3 and 293F cells, respectively. Both endogenous and recombinant calpain-10 were present as two major forms with different origins. Interestingly, radiolabeled calpain-10 was found to be efficiently cleaved at the N-terminal region by calpain-2, but not by other proteases. None of these calpain-10 proteins has putative proteolytic activity under in vitro conditions when examined using different peptide substrates, including more than 70 in vitro translated, radiolabeled oligopeptides. Our results raise the possibility that calpain-10 requires special intracellular localization or interacting partner(s) to acquire proteolytic activity, or it functions by interacting with other proteins rather than through its proteolytic activity.
Valleytronics in Tin (II) Sulfide
Creators: name: Rodin, A. S.
name: Gomes, L. C.
name: Carvalho, A.
name: Neto, A. H. Castro
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Tin (II) sulfide (SnS) is a layered mineral found in nature. In this paper, we study the two-dimensional form of this material using a combination of \emph{ab initio} calculation and $\mathbf{k}\cdot\mathbf{p}$ theory. In particular, we address the valley properties and the optical selection rules of 2D SnS. Our study reveals SnS as an extraordinary material for valleytronics, where pairs of equivalent valleys are placed along two perpendicular axes, can be selected exclusively with linear polarized light, and can be separated using non-local electrical measurements.
description: 4 Pages, 3 Figures
title: Optimising operational energy in high-rise office buildings in the UK. The path towards net zero carbon.
Creators: name: Ibrahimi, Arta
Publisher: name: University of Southampton
Year: 2022
Subjects: operational carbon, Energy efficiency, renewables, high-rise, net zero carbon

description: A framework by the UK Green Buildings highlights three key steps to achieve this goal: reducing emissions through efficiency, on-site or off-site renewable energy and using offsetting schemes to address the remaining balance. The high-rise office buildings have experienced a considerable rise recently, spending 68% of total non-domestic electricity use in the UK. Such buildings have a high energy demand and renewable energy sources arenât well suited for those structures. The current energy and emissions assessment method in England is compliance modelling, which presents a performance gap. This study will evaluate the possibilities for optimising energy use in a typical high-rise building. The analyses go beyond the scope of compliance modelling, addressing the performance gap, followed by the integration of renewables to address the remaining energy demand. Design and climatic applicability synthesise the primary outcomes of this study.
Uncovering chromatin’s contribution to the mitotic spindle: Applications of computational and polymer models
Creators: name: Larson, Matthew E.
name: Harrison, Benjamin D.
name: Bloom, Kerry
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The mitotic spindle is a structure that forms during mitosis to help ensure that each daughter cell receives a full complement of genetic material. In metaphase, the spindle contains microtubules that nucleate inward from two opposing poles. Chromosomes are attached to plus-ends of these microtubules via protein structures called kinetochores. The centromere is the specific region of kinetochore attachment on the chromosome. Chromatin surrounding the centromere (pericentric chromatin) is subject to microtubule-based forces and is commonly modeled as a linear spring, where the force that it exerts is proportional to the distance that it is stretched. We have incorporated physically based models of chromatin to create more accurate and predictive models of the spindle. In addition, using fluorescence microscopy and motion analysis of fluorescently labeled chromatin spots we discovered that pericentric chromatin is restrained relative to free diffusive motion. The characterization of chromatin is crucial to understand mitotic spindle stability and to understand the cell cycle checkpoint regulating anaphase onset.
Highly-Efficient Purification of Native Polyhistidine-Tagged Proteins by Multivalent NTA-Modified Magnetic Nanoparticles
Creators: name: Valencia, C. Alexander
name: Kim, Jason S.
name: Liu, Rihe
name: Lin, Wenbin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: A new bis-nitrilotriacetic acid (NTA) chelate with catechol anchor was synthesized and immobilized on superparamagnetic iron oxide nanoparticles. When loaded with Ni(II), these bis-NTA-immobilized nanoparticles were shown to bind polyhistidine (His×6-tagged) fusion proteins in their native, folded conformations that commercial microbeads failed to bind under identical conditions. Control experiments with a mono-NTA chelate immobilized on iron oxide nanoparticles indicate a similarly high affinity for His×6-tagged native proteins, suggesting that the high density of the mono-NTA chelate presented by the nanoparticles allows the binding of the His×6-tag to more than one Ni-NTA moiety on the surface. This study shows that the multivalency strategy can be utilized to enhance the binding of His×6-tagged proteins in their native, folded conformations. We further demonstrated the selective purification of His×6-tagged proteins from crude cell lysates by using the Ni(II)-loaded iron oxide nanoparticles. The present platform is capable of efficient purification of His×6-tagged proteins that are expressed at low levels in mammalian cells. This work thus presents a novel nanoparticle-based high-capacity protein purification system with shorter incubation times, proportionally large washes, and significantly smaller elution volumes compared to commercially available microbeads.
Simple One-Pot Preparation of Water-Soluble, Cysteine-Reactive Cyanine and Merocyanine Dyes for Biological Imaging
Creators: name: Toutchkine, Alexei
name: Hahn, Klaus M.
name: Nguyen, Dan Vinh
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: A simple one-pot-procedure for preparation of protein-reactive, water soluble merocyanine and cyanine dyes has been developed. The 1-(3-ammoniopropyl)-2,3,3-trimethyl-3H-indolium-5-sulfonate bromide (1) was used as a common starting intermediate. The method allows easy preparation of dyes with chloro and iodoacetamide side chains for covalent attachment to cysteine. By placing a sulfonato group directly on the dye fluorophore system, dyes with high fluorescence quantum yields in water were generated. Both iodo- and chloroacetamido- derivatives were shown to be useful in protein labeling. Less reactive chloroacetamides will be preferential for selective labeling of the most reactive cysteines.
Zur Frage der Genese der Rössener Kultur
Creators: name: Meier-Arendt, Walter
Publisher: name: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts
Year: 2023

description: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts, Bd. 52 Nr. 1 (1974)
title: Intracranial tuberculomas accompanied by a singular intramedullary tuberculoma
Creators: name: Castelao, Filipa
Publisher: name: EURORAD
Year: 2023
Subjects: subject: Neuroradiology
subject: Neuroradiology brain
subject: Neuroradiology spine
subject: MR
subject: Clinical Cases

description: Clinical History: A 62-year-old male, born in São Tomé, former ship kitchen assistant and without relevant medical history, was brought to the Emergency Department due to encephalopathy, cough, and thoracic pain that had been developing for two weeks. On examination, there were no signs of meningeal involvement or focal neurological deficits.

description: 62 years, male
title: Правовые основы деятельности участкового уполномоченного полиции
Creators: name: ELS IPR BOOKS
Publisher: name: Южно-Уральский технологический университет
Year: 2021

description: В работе приведен обзор современного законодательства, регулирующего несение службы участкового уполномоченного полиции, рассмотрены административно-правовые, уголовно-правовые, уголовно-процессуальные и иные компетенции участкового уполномоченного полиции. Учебное пособие предназначено для студентов, обучающихся по направлению 40.03.01 Юриспруденция, а также других направлений подготовки и специальностей в области права и правоохранительной деятельности. Учебное пособие может быть полезным и для практических работников правоохранительных органов. Нормативные правовые акты приведены по состоянию на 01.01.2021 г.
A discrete log-Sobolev inequality under a Bakry-Emery type condition
Creators: name: Johnson, Oliver
Publisher: name: arXiv
Year: 2015
Subjects: subject: Probability (math.PR)
subject: Information Theory (cs.IT)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences

description: We consider probability mass functions $V$ supported on the positive integers using arguments introduced by Caputo, Dai Pra and Posta, based on a Bakry--Émery condition for a Markov birth and death operator with invariant measure $V$. Under this condition, we prove a modified logarithmic Sobolev inequality, generalizing and strengthening results of Wu, Bobkov and Ledoux, and Caputo, Dai Pra and Posta. We show how this inequality implies results including concentration of measure and hypercontractivity, and discuss how it may extend to higher dimensions.
The Torus One-Point Diagram in Two-Dimensional String Cosmology
Creators: name: Rodriguez, Victor A.
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We calculate numerically the torus one-point string diagram in the two-dimensional string cosmology background by decomposing the one-point functions in $c=1$ and $c=25$ Liouville CFT into torus one-point Virasoro conformal blocks and integrating over the fundamental domain of the torus moduli space. We find a remarkably simple result as a function of the outgoing closed string energy. This torus one-point diagram is expected to contribute to the one-point cosmological wavefunction at order $g_s$, and to the four-point cosmological wavefunction at order $g_s^2$ through the disconnected product of the torus one-point diagram and the sphere three-point diagram.
description: 13 pages, 2 figures, 1 .nb Mathematica notebook attachment
Cellular Delivery and Biological Activity of Antisense Oligonucleotides Conjugated to a Targeted Protein Carrier
Creators: name: Kang, Hyunmin
name: Alam, Md Rowshon
name: Juliano, Rudy L.
name: Fisher, Michael
name: Dixit, Vidula
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Targeted delivery can potentially improve the pharmacological effects of antisense and siRNA oligonucleotides. Here we describe a novel bioconjugation approach to the delivery of splice-shifting antisense oligonucleotides (SSOs). The SSOs are linked to albumin via reversible S-S bonds. The albumin is also conjugated with polyethylene glycol (PEG) chains that terminate in an RGD ligand that selectively binds the αvβ3 integrin. As a test system we utilized human melanoma cells that express the αvβ3 integrin and that also contain a luciferase reporter gene that can be induced by delivery of SSOs to the cell nucleus. The RGD-PEG-SSO-albumin conjugates were endocytosed by the cells in an RGD-dependent manner; using confocal fluorescence microscopy evidence was obtained that the SSOs accumulate in the nucleus. The conjugates were able to robustly induce luciferase expression at concentrations in the 25−200nM range. At these levels little short-term or long-term toxicity was observed. Thus the RGD-PEG-Albumin conjugates may provide an effective tool for targeted delivery of oligonucleotides to certain cells and tissues.
Enhanced Potency of Nucleotide−Dendrimer Conjugates as Agonists of the P2Y 14 Receptor: Multivalent Effect in G Protein-Coupled Receptor Recognition
Creators: name: Zhou, Yixing
name: Jacobson, Kenneth A.
name: Carter, Rhonda L.
name: Ivanov, Andrei A.
name: Das, Arijit
name: Harden, T. Kendall
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The P2Y14 receptor is a G protein-coupled receptor activated by uridine-5′-diphosphoglucose and other nucleotide sugars that modulates immune function. Covalent conjugation of P2Y14 receptor agonists to PAMAM (polyamidoamine) dendrimers enhanced pharmacological activity. Uridine-5′-diphosphoglucuronic acid (UDPGA) and its ethylenediamine adduct were suitable functionalized congeners for coupling to several generations (G2.5–6) of dendrimers (both terminal carboxy and amino). Prosthetic groups, including biotin for avidin complexation, a chelating group for metal complexation (and eventual magnetic resonance imaging), and a fluorescent moiety, also were attached with the eventual goals of molecular detection and characterization of the P2Y14 receptor. The activities of conjugates were assayed in HEK293 cells stably expressing the human P2Y14 receptor. A G3 PAMAM conjugate containing 20 bound nucleotide moieties (UDPGA) was 100-fold more potent (EC50 2.4 nM) than the native agonist uridine-5′-diphosphoglucose. A molecular model of this conjugate docked in the human P2Y14 receptor showed that the nucleotide-substituted branches could extend far beyond the dimensions of the receptor and be available for multivalent docking to receptor aggregates. Larger dendrimer carriers and greater loading favored higher potency. A similar conjugate of G6 with 147 out of 256 amino groups substituted with UDPGA displayed an EC50 value of 0.8 nM. Thus, biological activity was either retained or dramatically enhanced in the multivalent dendrimer conjugates in comparison with monomeric P2Y14 receptor agonists, depending on size, degree of substitution, terminal functionality, and attached prosthetic groups.
Functionalized Congeners of P2Y 1 Receptor Antagonists: 2-Alkynyl ( N )-Methanocarba 2′-Deoxyadenosine 3′,5′-Bisphosphate Analogues and Conjugation to a Polyamidoamine (PAMAM) Dendrimer Carrier
Creators: name: Gachet, Christian
name: Costanzi, Stefano
name: Kilbey II, S. Michael
name: Harden, T. Kendall
name: Hechler, Béatrice
name: Brown Jr., Garth G.
name: Jacobson, Kenneth A.
name: De Castro, Sonia
name: Hong, Kunlun
name: Maruoka, Hiroshi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The P2Y1 receptor is a prothrombotic G protein-coupled receptor (GPCR) activated by ADP. Preference for the North (N) ring conformation of the ribose moiety of adenine nucleotide 3′,5′-bisphosphate antagonists of the P2Y1 receptor was established by using a ring-constrained methanocarba (a bicyclo[3.1.0]hexane) ring as a ribose substitute. A series of covalently linkable N6-methyl-(N)-methanocarba-2′-deoxyadenosine-3′,5′-bisphosphates containing extended 2-alkynyl chains was designed and binding affinity at the human (h) P2Y1 receptor determined. The chain of these functionalized congeners contained hydrophilic moieties, a reactive substituent, or biotin, linked via an amide. Variation of the chain length and position of an intermediate amide group revealed high affinity of carboxylic congener 8 (Ki 23 nM) and extended amine congener 15 (Ki 132 nM), both having a 2-(1-pentynoyl) group. A biotin conjugate 18 containing an extended ε-aminocaproyl spacer chain exhibited higher affinity than a shorter biotinylated analogue. Alternatively, click coupling of terminal alkynes of homologous 2-dialkynyl nucleotide derivatives to alkyl azido groups produced triazole derivatives that bound to the P2Y1 receptor following deprotection of the bisphosphate groups. The preservation of receptor affinity of the functionalized congeners was consistent with new P2Y1 receptor modeling and ligand docking. Attempted P2Y1 antagonist conjugation to PAMAM dendrimer carriers by amide formation or palladium-catalyzed reaction between an alkyne on the dendrimer and a 2-iodopurine-derivatized nucleotide was unsuccessful. A dialkynyl intermediate containing the chain length favored in receptor binding was conjugated to an azide-derivatized dendrimer, and the conjugate inhibited ADP-promoted human platelet aggregation. This is the first example of attaching a strategically functionalized P2Y receptor antagonist to a PAMAM dendrimer to produce a multivalent conjugate exhibiting a desired biological effect, i.e. antithrombotic action.
Polyamidoamine (PAMAM) Dendrimer Conjugates of “Clickable” Agonists of the A 3 Adenosine Receptor and Coactivation of the P2Y 14 Receptor by a Tethered Nucleotide
Creators: name: Hong, Kunlun
name: Gao, Zhan Guo
name: Barrett, Matthew O.
name: Jacobson, Kenneth A.
name: Harden, T. Kendall
name: Fricks, Ingrid P.
name: Kilbey II, S. Michael
name: Yoo, Lena S.
name: Chinn, Moshe
name: Tosh, Dilip K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: We previously synthesized a series of potent and selective A3 adenosine receptor (AR) agonists (North-methanocarba nucleoside 5′-uronamides) containing dialkyne groups on extended adenine C2 substituents. We coupled the distal alkyne of a 2-octadiynyl nucleoside by Cu(I)-catalyzed “click” chemistry to azide-derivatized G4 (fourth-generation) PAMAM dendrimers to form triazoles. A3AR activation was preserved in these multivalent conjugates, which bound with apparent Ki 0.1–0.3 nM. They were substituted with nucleoside moieties, solely or in combination with water-solubilizing carboxylic acid groups derived from hexynoic acid. A comparison with various amide-linked dendrimers showed that triazole-linked conjugates displayed selectivity and enhanced A3AR affinity. We prepared a PAMAM dendrimer containing equiproportioned peripheral azido and amino groups for conjugation of multiple ligands. A bifunctional conjugate activated both A3 and P2Y14 receptors (via amide-linked uridine-5′-diphosphoglucuronic acid), with selectivity in comparison to other ARs and P2Y receptors. This is the first example of targeting two different GPCRs with the same dendrimer conjugate, which is intended for activation of heteromeric GPCR aggregates. Synergistic effects of activating multiple GPCRs with a single dendrimer conjugate might be useful in disease treatment.
title: Организация деятельности участкового уполномоченного полиции
Creators: name: ELS IPR BOOKS
Publisher: name: Ай Пи Ар Медиа
Year: 2021

description: В учебном пособии изложены основы формирования полномочий участковых уполномоченных полиции, рассмотрены этапы становления и развития Челябинской школы милиции (1920–2020). Описаны правовые и организационные основы деятельности участкового уполномоченного полиции. Нормативные правовые акты приведены по состоянию на 01.01.2021 г. Учебное пособие подготовлено в соответствии с требованиями, предъявляемыми к изучению дисциплины «Организация деятельности участкового уполномоченного полиции», и предназначено для студентов, обучающихся по специальности среднего профессионального образования 40.02.02 «Правоохранительная деятельность».
Energy Injection in Gamma-ray Burst Afterglows
Creators: name: Laskar, Tanmoy
name: Berger, Edo
name: Margutti, Raffaella
name: Perley, Daniel
name: Zauderer, B. Ashley
name: Sari, Re'em
name: Fong, Wen-fai
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present multi-wavelength observations and modeling of Gamma-ray Bursts (GRBs) that exhibit a simultaneous re-brightening in their X-ray and optical light curves, and are also detected at radio wavelengths. We show that the re-brightening episodes can be modeled by injection of energy into the blastwave and that in all cases the energy injection rate falls within the theoretical bounds expected for a distribution of energy with ejecta Lorentz factor. Our measured values of the circumburst density, jet opening angle, and beaming corrected kinetic energy are consistent with the distribution of these parameters for long-duration GRBs at both z~1 and z>6, suggesting that the jet launching mechanism and environment of these events are similar to that of GRBs that do not have bumps in their light curves. However, events exhibiting re-brightening episodes have lower radiative efficiencies than average, suggesting that a majority of the kinetic energy of the outflow is carried by slow-moving ejecta, which is further supported by steep measured distributions of the ejecta energy as a function of Lorentz factor. We do not find evidence for reverse shocks over the energy injection period, implying that the onset of energy injection is a gentle process. We further show that GRBs exhibiting simultaneous X-ray and optical re-brightenings are likely the tail of a distribution of events with varying rates of energy injection, forming the most extreme events in their class. Future X-ray observations of GRB afterglows with Swift and its successors will thus likely discover several more such events, while radio follow-up and multi-wavelength modeling of similar events will unveil the role of energy injection in GRB afterglows.
description: 40 pages, 38 figures, 9 tables. Submitted to ApJ
A Molecular Umbrella Approach to the Intracellular Delivery of siRNA
Creators: name: Janout, Vaclav
name: Cline, Lauren L.
name: Fisher, Michael
name: Regen, Steven L.
name: Juliano, Rudolph L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: A series of diwalled and tetrawalled molecular umbrellas have been synthesized using cholic acid, spermidine, and lysine as starting material. Coupling of these molecular umbrellas to an octaarginine peptide afforded agents that were capable of promoting the transport of small interfering RNA (siRNA) to HeLa cells, as judged by the knockdown of enhanced green fluorescent protein (eGFP) expression. The efficiency of this knockdown was found to increase with an increasing number of facially amphiphilic walls present, and also when a cleavable disulfide linker was replaced with a non-cleavable, maleimido moiety. The knockdown efficiency that was observed for one tetrawalled molecular umbrella-octaargine conjugate was comparable to that observed with a commercially available transfection agent, Lipofectamine 2000, but showed less cytotoxicity.
Glycated AAV Vectors: Chemical Redirection of Viral Tissue Tropism
Creators: name: Weinberg, Marc S.
name: Horowitz, Eric D.
name: Asokan, Aravind
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: A chemical approach for selective masking of arginine residues on viral capsids, featuring an exogenous glycation reaction has been developed. Reaction of adeno-associated viral (AAV) capsids with the α-dicarbonyl compound, methylglyoxal resulted in formation of arginine adducts. Specifically, surface exposed guanidinium side chains were modified into charge neutral hydroimidazolones, thereby disrupting a continuous cluster of basic amino acid residues implicated in heparan sulfate binding. Consequent loss in heparin binding ability and decrease in infectivity were observed. Strikingly, glycated AAV retained ability to infect neurons in the mouse brain and were redirected from liver to skeletal and cardiac muscle following systemic administration in mice. Further, glycated AAV displayed altered antigenicity demonstrating potential for evading antibody neutralization. Generation of unnatural amino acid side chains through capsid glycation might serve as an orthogonal strategy to engineer AAV vectors displaying novel tissue tropisms for gene therapy applications.
Multivalent Cyclic RGD Conjugates for Targeted Delivery of Small Interfering RNA
Creators: name: Fisher, Michael
name: Rajeev, Kallanthottathil G.
name: Manoharan, Muthiah
name: Ming, Xin
name: Alam, Md Rowshon
name: Juliano, Rudy L.
name: Lackey, Jeremy G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: We have designed, synthesized and tested conjugates of chemically modified luciferase siRNA (Luc-siRNA) with bi-, tri- and tetravalent cyclic(arginine-glycine-aspartic) peptides (cRGD) that selectively bind to the αvβ3 integrin. The cellular uptake, subcellular distribution and pharmacological effects of the cRGD conjugated Luc-siRNAs as compared to un-conjugated controls were examined using a luciferase reporter cassette stably transfected into αvβ3 positive M21+ human melanoma cells. The M21+ cells exhibited receptor-mediated uptake of cRGD-siRNA conjugates but not of unconjugated control siRNA. The fluorophore-tagged cRGD-siRNA conjugates were taken up by a caveolar endocytotic route and primarily accumulated in cytosolic vesicles. The bi-, tri- and tetravalent cRGD conjugates were taken up by M21+ cells to approximately the same degree. However, there were notable differences in their pharmacological effectiveness. The tri- and tetravalent versions produced progressive, dose-dependent reductions in luciferase expression, while the bivalent version had little effect. The basis for this divergence of uptake and effect is currently unclear. Nonetheless the high selectivity and substantial ‘knock down’ effects of the multivalent cRGD-siRNA conjugates suggest that this targeting and delivery strategy deserves further exploration.
title: Full Body Radiography (LODOX Statscan) in Trauma Patients
Creators: name: Cerniauskaite, Reda
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Diagnostic procedure
subject: Conventional radiography
subject: Musculoskeletal bone
subject: Emergency
subject: Cost-effectiveness
subject: Dosimetry
subject: Trauma
subject: Acute

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To present the full body radiography system as an alternative examination method to CT scanning in trauma patients at emergency departments; To share LS images of polytrauma patients from Republican Vilnius University...
Photoluminescence of oxygen vacancies and hydroxyl group surface functionalized SnO_2 nanoparticles
Creators: name: Bonu, Venkataramana
name: Das, Arindam
name: Amirthapandian, S.
name: Dhara, Sandip
name: Tyagi, Ashok Kumar
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We report, for the first time, the luminescence property of the hydroxyl group surface functionalized quantum dots (QDs) and nanoparticles (NPs) of SnO_2 using low energy excitations of 2.54 eV (488 nm) and 2.42 eV (514.5 nm). This luminescence is in addition to generally observed luminescence from 'O' defects. The as-prepared SnO_2 quantum dots (QDs) are annealed at different temperatures in ambient conditions to create varied NPs in size. Subsequently, average size of the NPs is calculated from the acoustic vibrations observed at low frequencies in the Raman spectra and by the transmission electron microscopic measurements. Detailed photoluminescence studies with 3.815 eV (325 nm) excitation reveal the nature of in-plane and bridging 'O' vacancies as well as adsorption and desorption occurred at different annealing temperatures. X-ray photoelectron spectroscopy studies also support this observation. Defect level related to the surface -OH functional groups shows a broad luminescence peak around 1.96 eV in SnO_2 NPs which is elaborated with the help of temperature dependent studies.
description: 10 pages, 11 figures, journal
Study and Analysis of Parameter Errors of Passive Components using Genetic Algorithms
Creators: name: E N, ganesh
Publisher: name: figshare
Year: 2022
Subjects: subject: 90699 Electrical and Electronic Engineering not elsewhere classified
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In this paper, an automated method is developed to minimize the parameter extraction error of an on-chip broadband spiral inductor model. A MATLAB program based on the Genetic Algorithm Toolbox uses symbolic analysis to build the required equations to minimize the error between the measured and extracted Y parameters of the spiral inductor model. The proposed algorithm shows excellent agreement with the measured data over the entire frequency range.
Stopping power of high-density alpha-particle clusters in warm dense deuterium-tritium fuels
Creators: name: Fu, Z. P.
name: Zhang, Z. W.
name: Lin, K.
name: Wu, D.
name: Zhang, J.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: The state of burning plasma had been achieved in inertial confinement fusion (ICF), which was regarded as a great milestone for high-gain laser fusion energy. In the burning plasma, alpha particles incident on the cryogenic (warm dense) fuels cannot be simply regarded as single particles, and the new physics brought about by the density effects of alpha particles should be considered. In this work, the collective interaction between them has been considered, namely the effect of the superposition of wake waves. The stopping power of alpha-particle clusters, i.e. the rate of energy loss per unit distance traveled has been calculated using both analytical and simulation approaches. In theory, we obtain the stopping power of alpha clusters in cryogenic (warm dense) fuel by the dielectric function method, which illustrates the importance of the effective interaction between particles. Simulation results using the LAPINS code show that the collective stopping power of the alpha cluster is indeed increased via coherent superposition of excitation fields (the excitation of high-amplitude wake waves). However, the comparison between simulation and theoretical results also illustrates a coherent-decoherent transition of the stopping power of the cluster. The initial conditions with various sizes and densities of the alpha clusters have been considered to verify the condition of decoherence transition. Our work provides a theoretical description of the transport properties of high-density alpha particles in warm dense cryogenic fuel and might give some theoretical guidance for the design of actual fusion processes.
description: Junior undergraduate students Z. P. Fu, Z. W. Zhang and K. Lin contributed equally to this work
Targeted Albumin-Based Nanoparticles for Delivery of Amphipathic Drugs
Creators: name: Fisher, Michael
name: Xu, Rongzuo
name: Juliano, R. L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: We report the preparation and physical and biological characterization of human serum albumin-based micelles of approximately 30 nanometers diameter for the delivery of amphipathic drugs, represented by doxorubicin. The micelles were surface conjugated with cyclic RGD peptides to guide selective delivery to cells expressing the alpha v/beta 3 integrin. Multiple poly(ethylene glycol)s (PEGs) with molecular weight of 3400 daltons were used to form a hydrophilic outer layer, with the inner core formed by albumin conjugated with doxorubicin via disulfide bonds. Additional doxorubicin was physically adsorbed into this core to attain a high drug loading capacity, where each albumin was associated with about 50 doxorubicin molecules. The formed micelles were stable in serum but continuously released doxorubicin when incubated with free thiols at concentrations mimicking the intracellular environment. When incubated with human melanoma cells (M21+) that express the alpha v/beta 3 integrin, higher uptake and longer retention of doxorubicin was observed with the RGD-targeted micelles, than in the case of untargeted control micelles, or free doxorubicin. Consequently the RGD-targeted micelles manifested cytotoxicity at lower doses of drug than control micelles or free drug.
title: The use of 99mTc-MAA SPECT/CT as a valuable method of SIRT treatment evaluation
Creators: name: Narloch, Jerzy
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Interventional vascular
subject: Oncology
subject: Nuclear medicine
subject: Catheter arteriography
subject: SPECT-CT
subject: CT
subject: Radioembolisation
subject: Radiation therapy / Oncology
subject: Radiation effects
subject: Radiotherapy techniques
subject: Metastases

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: The main advantage of using Yttrium-90 isotope in palliative treatment of liver tumors is pure beta-radiation emission with its high energy and short half-life time.(1,2) But limitation of radioembolisation is a low healthy liver tissue tolerance to...
(Full Paper)Agricultural products and foodstuffs marketing Consumption trends .pdf
Creators: name: Kalogiannidis, Stavros
name: Chatzitheodoridis, Fotios
name: Melfou, Katerina
name: Kontogeorgos, Achilleas
Publisher: name: figshare
Year: 2022
Subjects: subject: 150301 Business Information Management (incl. Records, Knowledge and Information Management, and Intelligence)
subject: FOS: Economics and business
subject: 150201 Finance
subject: 150307 Innovation and Technology Management

description: This paper gives a general view overview of the different trends associated with consumption, marketing, health and overall lifestyle for foodstuffs and agriculture with reference to Greece. This paper helps to synthetize the multi-faced elements or aspects of food and agriculture in the world particularly Greece. This paper contributes to the efforts of bridging the exiting gaps concerning the economics of food marketing and consumption, lifestyle and health trends, as well as food production in a bid to offer a meaningful resource for effective food marketing in the agriculture sector. Farmers require such information to clearly understand their prospective consumers sand the prevailing trends of consumption. This paper is also of great importance to consumers since it offers a better understanding of the different numerical implications associated with a particular diet.
Moduli Spaces of Higher Spin Klein Surfaces
Creators: name: Natanzon, Sergey
name: Pratoussevitch, Anna
Publisher: name: arXiv
Year: 2015
Subjects: subject: Algebraic Geometry (math.AG)
subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: Primary 30F50, 14H60, 30F35, Secondary 30F60

description: We study the connected components of the space of higher spin bundles on hyperbolic Klein surfaces. A Klein surface is a generalisation of a Riemann surface to the case of non-orientable surfaces or surfaces with boundary. The category of Klein surfaces is isomorphic to the category of real algebraic curves. An m-spin bundle on a Klein surface is a complex line bundle whose m-th tensor power is the cotangent bundle. The spaces of higher spin bundles on Klein surfaces are important because of their applications in singularity theory and real algebraic geometry, in particular for the study of real forms of Gorenstein quasi-homogeneous surface singularities. In this paper we describe all connected components of the space of higher spin bundles on hyperbolic Klein surfaces in terms of their topological invariants and prove that any connected component is homeomorphic to a quotient of a Euclidean space by a discrete group. We also discuss applications to real forms of Brieskorn-Pham singularities.
description: v3: 21 pages, shortened sec. 2 (summary of previous results), added an example in sec. 4, added sec. 5 (applications in sing. theory), added references; v2: 25 pages, minor corrections, added references
title: Сотрудничество субъектов социально-трудовых отношений в формировании экологически устойчивой экономики
Creators: name: ELS IPR BOOKS
Publisher: name: Южно-Уральский технологический университет
Year: 2021

description: Проблемы сотрудничества субъектов трудовых отношений в управлении организациями были и ранее предметом исследования автора. В 2019 го ду Е.В. Аббасовой издана научная работа «Участие в управлении производительностью труда представительных органов работников». Также она принимала участие в совместно подготовленной монографии о конституционных основах представительства в трудовом праве, которая издана на средства государственной поддержки, выделенные в соответствии с распоряжением Президента РФ от 29.03.2013 г. 115 РП на основании конкурса. В настоящем исследовании на фоне новейших форм организации труда рассматриваются проблемы формирования экологически устойчиво экономики. Параграфы 4, 5 второй главы написаны совместно с заслуженным юристом РФ, кандидатом юридических наук, доцентом Южно-Уральского технологического университета В. А. Васильевым. Рассчитана на научных работников, аспирантов, студентов юридических факультетов и факультетов управления, а также на учителей, интересующихся проблемами управления в организациях.
Monuments of Hope, Gloom, and Glory in the Age of the Hunnic Wars
Creators: name: Bakker, Hans T.
Publisher: name: Zenodo
Year: 2016
Subjects: Gonda lecture, Huns, Huna, India

description: 24th Gonda Lecture:  Monuments of Hope, Gloom, and Glory in the Age of the Hunnic Wars, 50 years that changed India (484 - 534). Venue: KNAW, The Trippenhuis, Kloveniersburgwal 29, 1011 JV Amsterdam
description: https://www.knaw.nl/en/awards/funding/gonda-fund/gonda-lectures
Dipolar dark solitons
Creators: name: Pawlowski, Krzysztof
name: Rzazewski, Kazimierz
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We numerically generate, and then study the basic properties of dark soliton-like excitations in a dipolar gas confined in a quasi one dimensional trap. These excitations, although very similar to dark solitons in a gas with contact interaction, interact with each other and can form bound states. During collisions these dipolar solitons emit phonons, loosing energy, but accelerating. Even after thousands of subsequent collisions they survive as gray solitons and finally reach dynamical equilibrium with background quasiparticles. Finally, in the frame of classical field approximation, we verified, that these solitons appear spontaneously in thermal samples, analogously to the type II excitations in a gas of atoms with contact interaction.
description: 9 pages, 12 figures