cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
California Organic, Agroecological, and Regenerative (COAR) Transitions
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: The California Organic, Agroecological, and Regenerative (COAR) Transitions project aims to strengthen UC as an internationally-recognized leader in facilitating Equitable Agroecological Transitions (EATs) by coordinating and using UC resources to adapt to and mitigate climate change by advancing knowledge, policy, and action toward equitable transformations in agriculture, working lands, and food system to heal our damaged and damaging socio-ecological relationships. Considerable research exists on land management practices that increase farm-level climate resilience, biodiversity, and economic viability but the implementation of equitable transitions is thus far insufficient to meet California and UC climate action goals and the needs of historically underserved communities. The COAR Transitions project uses agroecology as a transdisciplinary framework to build upon decades of UC work by advancing research to enhance UC’s capacity to facilitate EATs in California through coordinated multicampus and statewide actions. The project’s four goals are: 1) mapping and understanding agroecological transitions; 2) centering equity for EATs; 3) developing community-shaped descriptions of the contextual factors governing how and why agroecological changes can happen (i.e. regionally specific theories of change), a statewide policy roadmap for EATs, and a tool for assessing progress toward EATs; and 4) facilitating coordinated institutional changes through enhanced UC undergraduate and graduate and extension education, proposals for changes to UC and state policy, and establishment of the UC EATs Consortium. These four goals form a vision for socially and ecologically accountable transitions from individual farms to regional food systems, engaging UC with local agricultural communities, diverse organizations, and state agencies to foster deep, equitable change. Bringing together key faculty, staff, and students from across the five UC Agricultural Experiment Station (AES) campuses, Agriculture and Natural Resources (ANR), and aligned interdisciplinary institutes — Agricultural Sustainability Institute (UCD), Berkeley Food Institute (UCB), Center for Agroecology (UCSC), Organic Agriculture Institute (ANR), and Sustainable Agriculture Research and Education Program (ANR) — will help leverage UC and community partnerships to accelerate and amplify EATs in California.
Water Reuse for Sustainable Agriculture: Erase PFAS and Organic Contaminants from Water-Food Nexus
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: This MRPI project aims to improve agriculture sustainability and agro-urban ecosystem health by developing innovative recycled water treatment technologies and management strategies for recycled wastewater irrigation in agriculture, and evaluating downstream contaminant removal from food production and water-soil-food ecosystem using edible crop irrigation research trials. Unrelenting water scarcity in many regions worldwide, including California and many regions in the United States, poses a formidable challenge to agriculture, which accounts for 50-90% of water use. The product of wastewater treatment plants can become an increasingly valuable nontraditional and sustainable water resource for irrigation. One important challenge is ensuring the high quality and quantity of agricultural products in light of chemical and microbial contaminants that may be present in recycled wastewater. Conventionally treated wastewater effluent contains a variety of contaminants including per-and poly-fluorinated Chemicals (PFAS), pharmaceuticals and personal care products (PPCPs) and pathogens that are heavily impacted by human activities. These recycled water derived contaminants substantially reduces plant growth and crop yield during recycled water irrigation. This project will: (1) Develop novel water treatment technologies to degrade chemical and microbial contaminants from recycled irrigation water, and evaluate their fate and transport in crops in the water-food nexus; (2) Develop water deficit irrigation management strategies to enhance water conservation and food production; (3) Evaluate soil health and microbial ecosystem adaptation in response to recycled water irrigation; (4) Develop novel on-farm implementable management practices (i.e., targeted crop use) to minimize the transfer of contaminants to food crops after recycled water irrigation. This project involves a combination of environmental, chemical, biological and agricultural engineering and extension expertise at the University of California, Riverside, Davis, Santa Barbara, and partnership with UC Agricultural Extension Centers in Riverside and Irvine in groundbreaking research activities. This project will enhance the UC’s portfolio to develop robust water resource management approaches in agriculture and conceive exciting new ideas on sustainability.
Unraveling disease pathways for autism spectrum disorder with phenotyping of human brain organoids.
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Autism spectrum disorder (ASD) affects 1 in 22 children in California, is untreatable and characterized by social, cognitive, motor and sensory deficits. The estimated lifetime social cost is 3.6 million per patient. Individuals affected with ASD can be challenged at work because of their difficulty to balance multitasking and focus. Additionally, challenges with communication and repetitive or inflexible behaviors often result in unemployment and isolation. The neurobiology of ASD remains unresolved. Animal models indicate alterations in the development, activity and plasticity of neural circuits. These processes can be studied in a human cellular context using neurons differentiated from human stem cells, including from patients. 2D neuronal cultures often oversimplify disease mechanisms and lack the complexity of organs. By contrast, brain organoids self-organize into 3D structures, represent fetal-like maturity and often more accurately model neurodevelopmental diseases. We will employ human brain organoids to study ASD mechanisms. Hundreds of ASD mutations have been identified. However, the mechanisms by which these mutations drive disease remain unclear. Here, we will uncover molecular, cellular, and developmental phenotypes driven by ASD-related mutations using brain organoids generated from ASD patient-derived cells as well as from ASD-gene CRISPR knockout cell lines from those same patient mutations. We will uncover the disease pathways through which ASD mutations act by analyzing neuronal differentiation and development, gene expression patterns, neuron structure and function, and neuronal activity. We will establish clinical relevance of disease mechanisms by relating them to patient brain imaging and clinical data. Understanding the pathways through which these ASD mutations cause disease will uncover new drug targets that can be pursued for ASD treatment and symptom relief. Our studies are significant because we will use patient-derived 3D disease models that represent human neurodevelopment, and we will assign clinical relevance to disease phenotypes discovered in a dish using the same patient’s imaging and clinical data. Our studies are impactful because the data we derive linking mutations to pathways will highlight therapeutic avenues for ASD treatment, which will increase employment of ASD individuals and lower the economic burden.
CALI-GREAT: California’s Groundbreaking and Responsible Evaluation of AI Tech for Sepsis Prevention
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Sepsis, a life-threatening health problem, presents a substantial burden with over 300,000 severe sepsis patients treated in 2022 and hospital charges totaling $84 billion in California. Despite a high mortality rate of 16% in our state, translating to over 47,000 deaths, recent advancements in artificial intelligence (AI) offer a beacon of hope. The COMPOSER model, developed by UC San Diego researchers and published in Nature Digital Medicine, has shown a promising 17% reduction in mortality. The COMPOSER model utilizes predictive analytics algorithms to analyze real-time data from electronic health records, assessing over 150 patient variables to detect early signs of sepsis. Its deployment in emergency departments has led to not only a reduction in mortality but also improved adherence to protocolized care. The overarching goal of this project is the statewide implementation of the COMPOSER model to enhance early sepsis prediction and improve patient outcomes across California's healthcare system, with an estimated 8,000 lives saved per year. However, as with most technologies, this potential must be balanced by identifying and mitigating possible risks for patient harm and the propagation of healthcare disparities. Our initiative will focus on external validation of the COMPOSER AI model at UC Irvine, UCLA and their affiliated community hospitals, by 1) identifying barriers to AI model deployment, including interoperability standards, data privacy, algorithmic transparency and bias, and provider and patient trust, 2) validating the model’s performance across diverse patient cohorts and healthcare settings, and 3) implementing a privacy-preserving federated learning platform to iteratively improve model performance based on end-user feedback. This comprehensive framework for employing clinical AI solutions will engage a diverse cross section of stakeholders to foster a robust and reliable AI ecosystem that can be scaled to benefit the entire state. Our interdisciplinary team, comprising experts in critical care, biomedical informatics, and privacy, will address the challenges of AI deployment, including patient privacy, consent, and unbiased implementation. The ultimate goal is to foster a trustworthy AI ecosystem, establish a new standard for sepsis care in California, significantly reduce mortality rates, and decrease healthcare expenditures.
Heat, Equity, and Integrated Resilience in Schools (HEIRS)
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Excessive heat is known to be deadly for exposed and vulnerable populations. Given the physiology of their bodies, children, in particular, are more sensitive to heat stress than adults. Exposure to heat can have negative effects on children including dehydration, heat exhaustion, heat cramps, and heat stroke, as well as adverse effects on cognitive performance. Nearly six million children are enrolled in California’s public schools. As California experiences increasing heat due to climate change, a key question is whether the state’s schools and public health officials are ready to protect children from heat effects. This project will evaluate the vulnerability of California school-aged children to extreme heat, and will work with school and public health end-users to develop action plans to mitigate this threat. To address this issue, we will meet several key outcomes. First, we will use multiple data sources to compile a database of observed and predicted heat exposure in public schools that will be communicated with end-users and made publicly available via a data dashboard. We will assess heat observations and projections for a sample of 9 public schools within Santa Barbara County, Orange County, and Yolo County. Second, we will assess vulnerability and adaptation to heat exposure in the sample of public schools within these counties. Using a mixed methods approach, and considering multiple metrics, we will investigate vulnerability and adaptation to heat among a sample of public schools in these counties. We will also engage in primary data collection to assess heat health literacy among families, school personnel, and public health end-users. Lastly, we will engage community end-users working in schools, and public health administrators focused on children, youth, and health, in this research. We will identify end-user needs and priorities in the areas of heat exposures, vulnerabilities, and adaptations in these counties, and will provide these end-users with the capacity to develop decision making tools and action plans to meet their needs and priorities in these areas. Our project will provide a model for conducting similar research in other regions of the state, eventually scaling up to include all public schools in California.
title: Linked-Employer-Employee-Daten des IAB: LIAB-Längsschnittmodell (LIAB LM) 1975-2017
title: LIAB LM 7517
titleType: AlternativeTitle
Creators: name: Schmidtlein, Lisa
name: Seth, Stefan
name: Umkehrer, Matthias
Publisher: name: Forschungsdatenzentrum (FDZ) der Bundesagentur für Arbeit (BA) im Institut für Arbeitsmarkt- und Berufsforschung (IAB)
Year: 2019

description: Die Linked-Employer-Employee-Daten des IAB (LIAB) kombinieren die Interviews des IAB-Betriebspanels mit den zugehörigen Betriebs- und Personendaten aus den Prozessen der Bundesagentur für Arbeit. Letztere umfassen einerseits die administrativen Betriebsinformationen aus dem Betriebs-Historik-Panel (BHP) und andererseits die Erwerbsbiographien der in den interviewten Betrieben beschäftigten Personen. Die LIAB Daten ermöglichen somit eine simultane Analyse der Angebots- und Nachfrageseite des Arbeitsmarktes.
UC Merced Nicotine and Cannabis Policy Center
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: UC Merced Nicotine and Cannabis Policy Center (NCPC) was established in 2018 with a Policy Center award from the Tobacco-Related Disease Research Program (TRDRP; 28PC-0044). NCPC is the only tobacco-related research center in California’s San Joaquin Valley (SJV) and serves all eight counties of the Valley, as well as three adjacent counties in the Sierra Foothills. Collectively, these counties represent a region with higher tobacco use, weaker tobacco control policies, and a higher burden of disease and death. Since its inception in 2018, NCPC has established itself as a unifying entity that provides essential support to regional tobacco control programs and community organizations. Activities within NCPC align with three major goals: a) to generate empirical data focused on SJV, b) disseminate data to community organizations and tobacco/cannabis stakeholders, and c) build the community’s capacity to support, create, and implement evidenced-based tobacco/cannabis prevention and control policies. The current application resubmission describes a revised strategic plan and programmatic goals for NCPC. This submission extends the work building on the existing foundation of NCPC. We incorporate lessons learned in the past four five years, as well as direct community input on regional needs. Specifically, NCPC will respond to community calls for 1) community-level support for tailored tobacco and cannabis prevention and cessation needs unique to SJV and 2) broader community involvement to support tobacco control activities and broaden awareness of California Endgame initiative. Activities include community-academic partnerships in tobacco policy implementation assessments, citizen scientist-led ambulatory data collection and information dissemination, and data dashboards that will be broadly disseminated to communities through infographics, visualized data, video series, and in-person consultations. Rapid research activities will include SJV-based data dashboard reflecting community partners' existing data collection and analysis of tobacco/nicotine retail environment. The proposed activities will leverage NCPC’s existing role in the region as a connector between formerly disparate organizations, as well as a key partner in critical research and policy development that will provide data and resources to the San Joaquin Valley and local Sierra Foothills.
sj-pdf-1-dhj-10.1177_2055207620925929 - Supplemental material for Service user and staff acceptance of fetal ultrasound telemedicine
Creators: name: Bidmead, Elaine
name: Lie, Mabel
name: Marshall, Alison
name: Robson, Stephen
name: Smith, Vikki J.
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: Cardiology
subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: 110308 Geriatrics and Gerontology
subject: 111099 Nursing not elsewhere classified
subject: 111299 Oncology and Carcinogenesis not elsewhere classified
subject: 111702 Aged Health Care
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies
subject: Anthropology
subject: FOS: Sociology
subject: 200299 Cultural Studies not elsewhere classified
subject: FOS: Other humanities
subject: 89999 Information and Computing Sciences not elsewhere classified
subject: FOS: Computer and information sciences
subject: 150310 Organisation and Management Theory
subject: FOS: Economics and business
subject: Science Policy
subject: 160512 Social Policy
subject: FOS: Political science
subject: Sociology

description: Supplemental material, sj-pdf-1-dhj-10.1177_2055207620925929 for Service user and staff acceptance of fetal ultrasound telemedicine by Elaine Bidmead, Mabel Lie, Alison Marshall, Stephen Robson and Vikki J. Smith in Digital Health
Tobacco-focused Care Enhancement of Existing Inpatient Substance Use Treatment Services
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: In California, 8% of the population, 2.7 million people, have a substance use disorder (SUD) and the smoking prevalence rate of the SUD population is 6-7 times higher than the general population. Tobacco dependence is high in the SUD population and treatment increases the likelihood of SUD treatment success. Historically, SUD treatment programs have been reticent to integrate tobacco treatment that ultimately led to recent legislative action in the form of Assembly Bill 541, which mandates screening and tobacco treatment at outpatient treatment facilities. Despite this effort, inpatient touchpoints remain a critical care gap for treating tobacco among patients with SUD. CA Bridge is a statewide, hospital-based program whose goal is to ensure every hospital in California has the capability to treat SUD. The program advises patients, connects them to inpatient and outpatient treatment, and follows-up after discharge. The CA Bridge SUD program treats opiates and other substances, yet tobacco treatment is not part of the protocol. Given the broad reach of CA Bridge, supplementation of existing inpatient services with tobacco care may prove critical to reduce tobacco use among people with SUD in California, a priority population with a high burden of tobacco use and related disease. This proposed study will test an intervention to introduce tobacco treatment to patients with SUD admitted to UC Davis Hospital—a CA Bridge program leader. The intervention will compare usual care (UC-TT) with inpatient pharmacist-delivered tobacco treatment (PD-TT); which will offer nicotine replacement therapy (NRT) and connect patients to quitline services. This study has two objectives. First, to refine and implement the PD-TT protocols with SUD treatment stakeholders at UC Davis Hospital for patients with SUD. Second, to evaluate implementation by assessing rates of NRT inpatient and at discharge, discharge quitline orders, and connection to quitline services among patients with SUD. The long-term goal of this study is to fill a gap in the continuum of tobacco-related care by providing patients with SUD tobacco treatment in an inpatient setting.
Criodion angustatum Buquet 1852
Creators: name: Martins, Ubirajara R.
name: Galileo, Maria Helena M.
name: Limeira-de-Oliveira, Francisco
Publisher: name: Zenodo
Year: 2009
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Criodion
Criodion angustatum

description: 20. Criodion angustatum Buquet, 1852
 Criodion angustatum Buquet, 1852: 358.
 Material examinado: Caxias (Povoado Descanso, luz posto da polícia), macho, 03.I.2007, F. Limeira-de-Oliveira col.; Mirador (Parque Estadual Mirador, Base da Geraldina), fêmea, 20-24.XII.2006, R.O. Souza & J.C. Silva col., armadilha luminosa; macho, 11-15. XI.2007, J.C. Silva col., luz mista.
description: Published as part of Martins, Ubirajara R., Galileo, Maria Helena M. & Limeira-de-Oliveira, Francisco, 2009, Cerambycidae (Coleoptera) do estado do Maranhão, Brasil, pp. 229-247 in Papéis Avulsos de Zoologia 49 (19) on page 234, DOI: 10.1590/S0031-10492009001900001, http://zenodo.org/record/13313584
Supplemental Material, Annex_v1_(1) - Brexit, the Press and the Territorial Constitution
Creators: name: Davies, Gregory
name: Wincott, Daniel
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law
subject: Sociology
subject: FOS: Sociology

description: Supplemental Material, Annex_v1_(1) for Brexit, the Press and the Territorial Constitution by Gregory Davies and Daniel Wincott in Social & Legal Studies
Effects of combustible cigarettes and e-cigarettes on infection and inflammation in oral cells
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Cigarette smoking harms nearly every organ of the body, and remains the leading cause of preventable disease, disability and death in the US. In 2019 approximately 34 million Americans were currently smoking. E-cigarettes (or vape) have been advertised as a healthier substitute to combustible cigarette smoking, but e-cigarette vapor still contains a wide range of deleterious products, including high levels of nicotine. One in five teens regularly engage in vaping, making them far more likely to end up smoking combustible cigarettes than those who have never vaped. Even though e-cigarettes generally contain fewer toxic chemicals compared to the deadly mix of 7,000 chemicals in smoke from combustible cigarettes, studies have shown they are still harmful and toxic. Combustible cigarette smoking and e-cigarette use have been linked to several diseases, including periodontitis. Periodontitis is an oral chronic inflammatory disease that affects approximately half of the US population and can cause irreversible tooth loss. There are studies showing an association between smoking (and e-cigarette use) and periodontitis in humans. However, how smoking and e-cigarette use lead to periodontitis still remain to be completely understood. We have previously shown that molecules from combustible cigarette smoke can stimulate the aryl hydrocarbon receptor (AhR) and facilitate infection in oral cells. Here we propose to investigate the role of AhR activation by combustible cigarettes and e-cigarettes on infection with periodontal pathogens, and on innate immune responses against the periodontal pathogens in human oral cells. We will evaluate whether combustible cigarettes and e-cigarettes modulate microbial infection in oral cells via AhR activation. We will also examine whether combustible cigarettes and e-cigarettes modulate the host response called “inflammasome” to oral microbes in human oral cells via AhR activation. Inflammasomes are a group of proteins that can sense cellular stress or damage and can initiate an inflammatory response. Our findings will help better understand the cellular mechanisms involved in the pathophysiology of tobacco-related periodontitis. As pharmacological activators and inhibitors of AhR are already being developed, our findings may raise the possibility of targeting AhR therapeutically for treatment of smoking-induced diseases.
Examining tobacco regulatory policy spillover effects on consumer preferences for tobacco products
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Cigarette smoking kills upwards of 400,000 Americans annually. While California (CA) remains a leader of the nation’s tobacco control efforts, an estimated 2.8 million residents continue to smoke. Attractive marketing, high levels of nicotine, and flavoring make tobacco products highly enticing and addictive leading to initiation and prolonged use. To impede smoking-related death and disease, several cigarette-specific federal regulatory actions may be taken, including: 1) banning menthol flavors, 2) reducing nicotine; and 3) requiring graphic health warning labels. Not wishing to wait for federal action, CA began prohibiting the sale of all flavored tobacco products including menthol cigarettes. Considering, “As goes California, so goes the nation”, the tobacco industry attempted to stop CA’s flavor ban but were unsuccessful. As a result, they instead began circumventing the law by developing replacements for flavored products such as ‘non-menthol’ cigarettes and ‘clear’ e-cigarettes, which contain artificial cooling agents that impart a cooling effect but lack a minty odor or flavor. Given the rise in popularity of e-cigarettes, authorization of heated tobacco products, use of new cooling agents, it is critical to understand how preferences for tobacco products may shift in response to these regulations and industry actions. Several questions are unanswered: Will former menthol smokers’ preferences shift to replacement “non-menthol” cigarettes? Will regulatory actions change smokers’ preferences for non-combusted tobacco products? Will shifts in tobacco product preferences differ among sociodemographic populations, and could this lead to widening health disparities? This project will answer these questions by employing a set of experimental tobacco purchase tasks in which smokers’ make hypothetical purchase decisions designed to uncover their preferences for various tobacco products (cigarettes, e-cigarettes, heated tobacco) and their accompanying features (flavors, nicotine, warnings) and determine their willingness to pay (or avoid) such features. We will recruit two cohorts of 1,050 adult daily smokers (2,100 total) aged 18-to-65, surveyed one year apart, to reveal changes in tobacco product preferences. Our findings will help determine any unforeseen impact that regulatory policies may have non-combustible tobacco product use in CA.
title: Linked Employer-Employee Data from the IAB: LIAB Longitudinal Model (LIAB LM) 1975-2017
title: LIAB LM 7517
titleType: AlternativeTitle
Creators: name: Schmidtlein, Lisa
name: Seth, Stefan
name: Umkehrer, Matthias
Publisher: name: The Research Data Centre (FDZ) of the German Federal Employment Agency (BA) at the Institute for Employment Research (IAB)
Year: 2019

description: The Linked-Employer-Employee-Data of the IAB (LIAB) combine interviews from the IAB Establishment Panel with the related establishment and individual data generated in labour administration and social security data processing. The latter cover administrative establishment information from the Establishment History Panel (BHP) and the employment biographies of individuals employed by the interviewed establishments. The LIAB data allow for simultaneous analysis of the supply and demand side of the German labour market.
Double trouble: the effects of dual cannabis and tobacco use on vascular function
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Our hearts and blood vessels play a vital role in keeping us healthy and active. However, certain lifestyle choices like smoking can have detrimental effects on our heart health. Tobacco smoke, for instance, has been extensively studied and is known to harm the heart and blood vessels, increasing the risk of heart diseases. On the other hand, marijuana remains less understood concerning its impact on heart function. In this research project, we aim to shed light on how dual tobacco and marijuana smoking affect our vessel function. By investigating the effects of both substances combined, we hope to determine if there are potential risks to the heart and vessels that were previously unknown. To conduct this clinical study, we will analyze how dual tobacco and marijuana smoking impacts the lining of our blood vessels, known as the endothelium. The endothelium plays a crucial role in regulating blood flow and maintaining a healthy cardiovascular system. We will compare the effects of dual use with those of tobacco-only and marijuana-only use to better understand the unique impact of combining these substances. The heart and vessel function will be studied using an ultrasound machine and electrocardiogram. Additionally, blood samples will be collected from our study participants to study the changes in the blood. We anticipate that our study will contribute valuable insights into the effects of dual tobacco and marijuana smoke on heart and vessel health. By revealing the potential risks associated with dual use, we can provide healthcare professionals, policymakers, and the public with evidence-based information to promote heart-healthy decisions. This project endeavors to address an important knowledge gap regarding the effects of both marijuana and tobacco smoke on the heart and vessel health. By understanding the potential risks of dual use, we hope to foster heart-healthy lifestyles and improve the overall health and well-being of our communities.
Novel therapy to treat nicotine-induced fibrogenesis
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Cigarette smoking is associated with the risk of developing fibrosis. Fibrosis is the pathophysiological response to chronic injury resulting in excessive extracellular matrix protein deposition and scarring. In the heart, excessive cardiac fibrosis triggers tissue stiffness, ultimately progressing to heart failure and increasing mortality. Despite the diversity of underlying etiologies that can lead to fibrosis, the common biochemical and cellular mechanism is the transdifferentiation of quiescent fibroblasts to activated myofibroblasts (MyoFB, ACTA2+), which can be stimulated by nicotine. Currently, there is no therapy to target myofibroblast activation for cardiac fibrosis in clinics. Here, I will provide evidence for the antifibrotic effects of a new compound. I will describe the prospective mechanism of action and a drug development plan aiming to treat nicotine-induced fibrogenesis. The approach represents a proof-of-concept of leveraging the human stem cell platform, animal model, and state-of-the-art molecular experiments as a drug development strategy. The compound has the potential to become a novel therapy to treat nicotine-induced fibrogenesis.
Additional file 1 of Examining the role of intrinsic and reflexive contributions to ankle joint hyper-resistance treated with botulinum toxin-A
Creators: name: van’t Veld, Ronald C.
name: Flux, Eline
name: van Oorschot, Wieneke
name: Schouten, Alfred C.
name: van der Krogt, Marjolein M.
name: van der Kooij, Herman
name: Vos-van der Hulst, Marije
name: Keijsers, Noël L. W.
name: van Asseldonk, Edwin H. F.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Additional file 1. Best-case minimal detectable difference for the intrinsic and reflexive joint resistance measures.
The Effect of Perinatal Nicotine Exposure on the Lung Circadian Molecular Clock
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Currently, chronic lung disease (CLD) affects over 500 million people worldwide and is the third leading cause of death globally. It is known to have a diverse set of predisposing etiologies, but the underlying molecular mechanisms involved remain incompletely understood. Recently, disruption of circadian rhythms, a highly conserved phenomenon in most mammalian tissues and organs, has been linked to inflammation, premature aging, and playing a significant role in the lung health of adults. For example, jet lag and cigarette smoking are known to disrupt clock gene expression; and persons who work irregular hours are more prone to the development of asthma and CLD. However, the role of the molecular clock in the developing lung has remained largely understudied. New evidence suggests that molecular clock expression in the lung is present early in the fetus, making circadian rhythms a potentially highly relevant factor in lung development and later pulmonary morbidity. This is also highly pertinent since smoking during pregnancy and lactation is strongly linked to CLD, however, its impact on clock genes that regulate the circadian rhythm is unknown. Due to the recent increase in the use of electronic cigarettes by pregnant women, this issue has become even more relevant. Using our well-established rat and human lung tissue models and elegant genetic models, we propose to examine the effects of tobacco smoke and nicotine exposure during pregnancy and lactation on the circadian clock genes. In addition, we also propose to examine the effects of a novel class of drugs, i.e., clock gene modulators, known as chronotherapeutics, with the goal to block perinatal smoke exposure and electronic vaping related lung morbidities such as predisposition to asthma, premature aging, and CLD. Despite all efforts, approximately 10% of U.S. women smoke during pregnancy, resulting in at least 450,000 smoke-exposed infants per year, rendering the work proposed here highly pertinent. Given our previous significant contributions to advance the mechanistic understanding of tobacco smoke/nicotine-induced programming of the developing lung, we are confident that the proposed work will not only provide novel therapeutic targets to prevent nicotine-induced CLD but will also significantly advance TRDRP’s mission to end all commercial tobacco products in California by the year 2035.
Supplemental_Table_2 - Semi-Automated Assessment of Human Islet Viability Predicts Transplantation Outcomes in a Diabetic Mouse Model
Creators: name: Salgado, Mayra
name: Gonzalez, Nelson
name: Medrano, Leonard
name: Rawson, Jeffrey
name: Omori, Keiko
name: Meirigeng Qi
name: Al-Abdullah, Ismail
name: Kandeel, Fouad
name: Mullen, Yoko
name: Hirotake Komatsu
Publisher: name: SAGE Journals
Year: 2020
Subjects: Medicine
Cell Biology

description: Supplemental_Table_2 for Semi-Automated Assessment of Human Islet Viability Predicts Transplantation Outcomes in a Diabetic Mouse Model by Mayra Salgado, Nelson Gonzalez, Leonard Medrano, Jeffrey Rawson, Keiko Omori, Meirigeng Qi, Ismail Al-Abdullah, Fouad Kandeel, Yoko Mullen and Hirotake Komatsu in Cell Transplantation
Parental Nicotine Use History and Early-Life Markers of Response to Acute Nicotine
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Nicotine and tobacco-related product (NTP) use is common in adolescents/young adults and is a leading cause of preventable disease and death. Despite tremendous gains in the alcohol literature, little research has investigated the role of parental nicotine use history on level of response to acute nicotine, and whether changes in brain function in response to acute nicotine prior to regular nicotine use and during peak, overlapping periods of neural development and heightened substance use (e.g., ages 18-25), predict important substance use outcomes. The sensitivity model suggests that those who experience greater positive effects from initial experimentation with nicotine are at greater risk for nicotine dependence. However, prospective data examining early-life objective brain-behavior markers to acute nicotine in individuals with and without parental nicotine use histories and its relation to future nicotine use does not exist. Initial response to nicotine (a highly addictive chemical compound) may serve as an early-life vulnerability that could contribute to and predict NTP and other substance use and addiction-related behaviors over time. This project will recruit 100 young adults with positive or negative parental nicotine use histories to undergo an initial baseline protocol followed by a remote follow-up interview 18 months later. The baseline visits (ages 18-19) will involve a randomized, placebo-controlled, within-subjects crossover neuroimaging protocol assessed following a dose of 2mg nicotine and a matched placebo. At both baseline visits, following drug administration, participants will receive a resting pseudo-continuous arterial spin labeling (PCASL) scan to assess nicotine-related changes in cerebral blood flow (CBF), task-based functional magnetic resonance imaging (fMRI) scans to assess nicotine-related changes to neural markers of cognitive processing, and complete subjective measures of nicotine response. The 18-month follow-up interview will involve remote substance use assessments. Broadly, the aims of the study are to (1) determine whether early-life neurobehavioral and subjective markers are altered by acute nicotine exposure and (2) determine whether level of response to nicotine at ages 18-19 predicts substance-related outcomes 1.5 years later and whether these relationships are moderated by parental history of nicotine use.
The effect of social media influencer marketing on e-cigarette perceptions and use by adolescents.
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: E-cigarette use among adolescents remains a concern in the United States. In California, 18% of high school students used electronic vapor products on at least one day in the past 30 days. Exposure to social media advertising is associated with e-cigarette use among youth. Social media influencers are regarded as more trusted and authentic than traditional advertising. We identified engaging micro-influencers (users with 1,000-100,000+) followers who promote e-cigarettes. Some of these influencers are based in California. Their posts frequently have non-compliant disclosures of partnerships with tobacco brands and/or lack the FDA-required nicotine warning labels and age restrictions, in violation of the U.S. Federal Food and Drug Administration (FDA) and the Federal Trade Commission (FTC) marketing restrictions. Influencers who promote e-cigarettes also use audio-visual effects in promotional pots, including stylization of influencers to look young, use of popular songs, autonomous sensory meridian response (ASMR) sounds or motivational narration and depiction of e-cigarettes in attractive and youth-oriented lifestyle contexts (e.g., healthy lifestyle, technology, gaming). These tactics could diminish adolescents’ harm perceptions of e-cigarettes, contribute to normalization of e-cigarette use, and expose e-cigarette never-users to e-cigarette content. Data from our adolescent surveys and focus groups show that influencers who were perceived as “young-looking,” who showed e-cigarettes as part of their daily life (e.g., using e-cigarettes and exercising) or used novel marketing features like ASMR were considered more relatable compared to influencers who look “older,” who overtly promote e-cigarettes without any non-substance-use context, or who did not use novel marketing features. To understand the impact of these marketing tactics on California youth, the proposed study will conduct randomized online experiments and in-person eye-tracking experiments to analyze the effects of audio-visual components of e-cigarette influencer marketing that could contribute to normalization of e-cigarette use. Findings will inform California tobacco control programs and prevention curriculum developers about the effect of new e-cigarette social media marketing techniques on tobacco use among California adolescents.
Urban-PLUMBER: Site information webpage (archive of https://urban-plumber.github.io/sites)
Creators: name: Lipson, Mathew
name: Grimmond, Sue
name: Best, Martin
name: Christen, Andreas
name: Coutts, Andrew
name: Crawford, Ben
name: Heusinkveld, Bert G.
name: Velasco, Eric
name: Ward, Helen Claire
name: Sugawara, Hirofumi
name: Hong, Je-Woo
name: Hong, Jinkyu
name: Evans, Jonathan
name: McFadden, Joeseph P.
name: Lee, Keunmin
name: Fortuniak, Krzysztof
name: Järvi, Leena
name: Roth, Matthias
name: Chrysoulakis, Nektarios
name: Tapper, Nigel
name: Michels, Oliver
name: Kotthaus, Simone
name: Earl, Stevan
name: Jo, Sungsoo
name: Masson, Valéry
name: Chow, Winston
name: Pawlak, Wlodzimierz
name: Kim, Yeon-Hee
Publisher: name: Zenodo
Year: 2021
Subjects: urban flux tower observations land surface model evaluation

description: A snapshot of web pages describing the site location information and observations used in the Urban-PLUMBER model evaluation project for urban areas (2021-09-20). Live webpage available at: https://urban-plumber.github.io/sites Observational data files themselves are NOT included. Access observational data files from: https://doi.org/10.5281/zenodo.6590886
description: This study was supported by the Australian Research Council (ARC) Centre of Excellence for Climate System Science (grant CE110001028) and ARC Centre of Excellence for Climate Extremes (grant CE170100023).
Appendix_7 – Supplemental material for Societal gender inequality and the gender gap in safety perceptions: Comparative evidence from the International Crime Victims Survey
Creators: name: Ntasha Bhardwaj
name: Apel, Robert
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 160299 Criminology not elsewhere classified
subject: FOS: Law
subject: 120505 Regional Analysis and Development
subject: FOS: Social and economic geography

description: Supplemental material, Appendix_7 for Societal gender inequality and the gender gap in safety perceptions: Comparative evidence from the International Crime Victims Survey by Ntasha Bhardwaj and Robert Apel in European Journal of Criminology
Novel vulnerabilities of highly aggressive tobacco-associated lung carcinomas
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2025

description: Lung cancer is the leading cause of deaths by cancer worldwide, and tobacco use is a well-established risk factor. Lung carcinomas associated with exposure to commercial tobacco products often carry mutations that make them highly aggressive and difficult to treat. This proposal focuses on a subtype of tobacco-associated lung carcinomas that is highly aggressive and resistant to all available clinical treatments: those with co-mutations in KRAS, LKB1 and KEAP1. Patients with these tumors have few therapeutic options and very poor survival. We found that these lung carcinomas are highly sensitive to an experimental drug (PCLX-001) that is currently in clinical trial for lymphoma. We investigated the molecular mechanism by which KRAS, LKB1 and KEAP1 mutant cells are sensitive to this drug and found a mitochondrial protein that is essential for the viability of these tumors. Our previous research, funded by a TRDRP Pilot award, also revealed new information about the intricate biology of these carcinomas. Lastly, we found that the effectiveness of this drug can be potentiated by other clinically approved and experimental drugs. We seek to investigate these promising findings to further our understanding of the vulnerabilities of these intractable tumors and provide proof of principle of the effectiveness of this drug as single agent and in combination. We hope that our research allows the translation of our preclinical data into urgently needed novel therapeutic strategies for these patients.
Supplementary_Materials – Supplemental material for How do conflict narratives shape conflict- and peace-related outcomes among majority group members? The role of competitive victimhood in intractable conflicts
Creators: name: Uluğ, Özden Melis
name: Lickel, Brian
name: Leidner, Bernhard
name: Hirschberger, Gilad
Publisher: name: SAGE Journals
Year: 2020
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, Supplementary_Materials for How do conflict narratives shape conflict- and peace-related outcomes among majority group members? The role of competitive victimhood in intractable conflicts by Özden Melis Uluğ, Brian Lickel, Bernhard Leidner and Gilad Hirschberger in Group Processes & Intergroup Relations