cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Langzeit-Outcome von Parkinson-Patienten mit chronischer bilateraler tiefer Hirnstimulation im Ncl. subthalamicus in Bezug auf Kognition, Motorik, Lebensqualität und Affekt
Creators: name: Calmbach, Lisa Brigitte
Publisher: name: Otto-von-Guericke-Universität Magdeburg
Year: 2019
Subjects: subject: Parkinson-Krankheit
subject: Hirnstimulation
subject: 616.83306

description: Die STN-THS gilt als bewährte Behandlungsmethode von Patienten mit IPS und motorischen und nichtmotorischen Wirkfluktuationen, neurokognitive- und psychiatrische Folgen werden kontrovers diskutiert. Von 104 Patienten mit IPS, die sich zwischen 1996 und 2006 an einem Fachzentrum einer bilateralen STN-THS unterzogen, konnte im Rahmen der vorliegenden neuropsychologischen Langzeit-Studie bei 79 Patienten präoperative kognitive Testungen ausgewertet werden. Von diesen Patienten waren zum Zeitpunkt der Nachuntersuchung 21 verstorben, 9 nicht kontaktierbar und 12 lehnten eine Testung ab. 37 Patienten wurden mittels einer umfangreichen neuropsychologischen Testung der kognitiven Domänen Sprache, exekutive Funktionen, Aufmerksamkeit, Visuokonstruktion und Gedächtnis nachuntersucht und allgemeine und motorische Daten sowie psychiatrische Symptome mittels Fremd- und Selbstbeurteilungsinstrumenten erfasst. Die Ergebnisse wurden mit den präoperativen Daten verglichen und es erfolgte die Zuordnung in die Kategorien kognitiv unauffällig, PD-MCI und PD-D nach Kriterien der MDS. Patienten zeigten über einen Zeitraum von 6,3±2,2 Jahren mit THS-STN insgesamt eine deutliche Zunahme kognitiver Defizite in vier von fünf kognitiven Domänen, partiell auch depressiver sowie (v.a. axialer) motorischer Symptome und eine Reduktion der krankheitsspez. Lebensqualität. Weitere psychiatrische Symptome nahmen nicht zu. Von präoperativ 76% Patienten mit PD-MCI und 24% mit unauffälliger Kognition wurden postoperativ jeweils 41% den Kategorien PD-D bzw. PD-MCI zugeordnet, während 18% kognitiv unauffällig blieben. Dabei korrelierte die Erkrankungsdauer, nicht das Alter mit der postoperativen Einschränkung kognitiver Funktionen. Es gab einen Trend zu einer Vergesellschaftung eines präoperativen PD-MCI mit einer Demenz bei Follow-Up.
Focal rigidity of hyperbolic surfaces
Creators: name: Kwakkel, Ferry
Publisher: name: arXiv
Year: 2011
Subjects: subject: Differential Geometry (math.DG)
subject: Geometric Topology (math.GT)
subject: FOS: Mathematics

description: In this note, we consider the rigidity of the focal decomposition of closed hyperbolic surfaces. We show that, generically, the focal decomposition of a closed hyperbolic surface does not allow for non-trivial topological deformations, without changing the hyperbolic structure of the surface. By classical rigidity theory this is also true in dimension $n \geq 3$. Our current result extends a previous result that flat tori in dimension $n \geq 2$ that are focally equivalent are isometric modulo rescaling.
description: Published in Annales Academiae Scientiarum Fennicae Mathematica, Volumen 37, 2012, 149-159, 11 pages
Electronic Supplementary Materials 1 from Orangutan information broadcast via consonant-like and vowel-like calls breaches mathematical models of linguistic evolution
Creators: name: Lameira, Adriano R.
name: Alexandre, António
name: Gamba, Marco
name: Nowak, Matthew G.
name: Vicente, Raquel
name: Wich, Serge
Publisher: name: The Royal Society
Year: 2021
Subjects: subject: Biophysics
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 60801 Animal Behaviour

description: Descriptive statistics
Statistical significance in high-dimensional linear models
Creators: name: Bühlmann, Peter
Publisher: name: arXiv
Year: 2012
Subjects: subject: Methodology (stat.ME)
subject: Statistics Theory (math.ST)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: We propose a method for constructing p-values for general hypotheses in a high-dimensional linear model. The hypotheses can be local for testing a single regression parameter or they may be more global involving several up to all parameters. Furthermore, when considering many hypotheses, we show how to adjust for multiple testing taking dependence among the p-values into account. Our technique is based on Ridge estimation with an additional correction term due to a substantial projection bias in high dimensions. We prove strong error control for our p-values and provide sufficient conditions for detection: for the former, we do not make any assumption on the size of the true underlying regression coefficients while regarding the latter, our procedure might not be optimal in terms of power. We demonstrate the method in simulated examples and a real data application.
description: Published in at http://dx.doi.org/10.3150/12-BEJSP11 the Bernoulli (http://isi.cbs.nl/bernoulli/) by the International Statistical Institute/Bernoulli Society (http://isi.cbs.nl/BS/bshome.htm)
Cryo-electron microscopy studies of native cell extracts : elucidating an active pyruvate dehydrogenase complex from Chaetomium thermophilum
Creators: name: Kyrilis, Fotios L.
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 570

description: An der oxidativen Decarboxylierung von Pyruvat ist einer der kritischsten und wichtigsten Komplexe beteiligt, der Pyruvat-Dehydrogenase-Komplex (PDHc) Enzymverbund. PDHc besteht aus drei Kernkomplexen. Aufgrund seiner Heterogenität, Größe und Plastizität wurde die quaternäre Struktur von PDHc bisher noch nie im Detail untersucht. In der vorliegenden Arbeit wurden vollständig aufgebaute C. thermophilum α-Ketosäure-Dehydrogenase-Komplexe in nativen Zellextrakten identifiziert. Ihre Domänenanordnungen wurden mit Hilfe von Proteomik, Aktivitätsuntersuchungen, Vernetzung, Elektronenmikroskopie und Computermodellierung charakterisiert. Es wurde eine Kryo-EM-Struktur des PDHc-Kerns veröffentlicht. Neben der Visualisierung von Faltung und Bindungsvorgängen wurde eine asymmetrische Rekonstruktion einer 10-MDa-PDHc dargestellt. Die Nähe der Komponenten wurde zusammen mit den vorgeschlagenen stöchiometrischen Daten sowie einem minimalen Reaktionsweg zwischen den Komponentenenzymen beschrieben.
description: The oxidative decarboxylation of pyruvate involves one of the most critical and key playing complexes, the enzymatic assembly known as Pyruvate Dehydrogenase Complex (PDHc). PDHc consists of three core components E1, E2/E3BP and E3 in multiple copies. Due to its heterogeneity, relatively enormous size and plasticity, the quaternary structure of PDHc has never been addressed in detail before. In the current work, fully assembled Chaetomium thermophilum α-keto acid dehydrogenase complexes in native cell extracts were identified. Their domain arrangements were characterised utilising proteomics, activity assays, crosslinking, electron microscopy and computational modelling. A cryo-EM structure of the PDHc core was reported. Besides visualised folding and binding events an asymmetric reconstruction of a 10-MDa PDHc was illustrated. The spatial proximity of its components was described and along with the proposed stoichiometric data, suggested a minimum reaction path among component enzymes.
Urban Functional Specialisation and the Interplay between Firm’s Communication Costs
Creators: name: Gori, Giuseppe Francesco
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2013
Subjects: SECS-P/01 Economia politica

description: This paper focuses on the functional specialisation of a system of cities, with particular attention to the role and the formation process of secondary business centers.
At the European level, the latters can be identified in the large number of regional capitals, and properly defined as cities hosting both headquarters of multi-location firms and providers of standard non-tradable business services (SBS). I present a theoretical model in which the changes in urban system’s degree of functional specialisation are linked to (i) firms’ organisational choices, since firms decide whether splitting into headquarter and production plant or remaining integrated in a single establishment and to (ii) firms’ location decision with regards to the proximity with the tradable advanced business services providers. I model two types of communication costs, one between headquarters and advanced tradable business services providers (ABS) and one between headquarters and production plants. The interplay between the two types of communication costs is shown to have effects on the transition process from an “integrated” urban system where each city hosts every different functions to a “functionally specialised” urban system where each city is either a primary business center (hosting ABS), a secondary business centers (SBS) or a pure manufacturing city and all this city-types coexist in equilibrium. In particular, I find that maximum functional specialisation of the urban system turns out to be feasible only if firms face a very high share of the total costs represented by their heaquarter spending.
Testing the limits : king Chŏngjo and royal power in late Chosŏn
Creators: name: Lovins, Christopher
Publisher: name: University of British Columbia
Year: 2014

description: The present work examines the attempt of Chŏngjo, King of Korea from 1776 to 1800, to shift the balance of power in late Chosŏn Korea in favor of the crown. It examines the official court records, the King’s official writings, and the recent discovery of Chŏngjo’s “secret” letters to high official and ostensible enemy Sim Hwan-ji, using them to illustrate how the King navigated the labyrinthine webs of power. Chapter 1 lays the groundwork of late Chosŏn history and examines Chŏngjo’s legitimacy issues arising from the death of his father. Chapter 2 deals with political philosophy, as Chŏngjo struggled with the aristocracy over the proper interpretation of Neo-Confucian ideology. Chapter 3 addresses how Chŏngjo dealt with the various power groups at court. After looking at his early struggles with the machinations of Hong Kuk-gyŏng, it examines the intrigues against his half-brother Prince Ŭn-ŏn, his aunt Princess Hwawŏn, and his uncle Hong In-han, and reveals how the King sought to protect royal relatives to preserve the majesty of the royal clan and to dispel any pretensions his mother’s family may have had of dominating the throne. The chapter then turns to Chŏngjo’s handling of the major political factions and his subtle refinement of the Policy of Impartiality. Chapter 4 looks at Chŏngjo’s efforts to institute a system to perpetuate royal power. After briefly examining his struggles with the bureaucracy over a key government position, the chapter investigates his creation of two new administrative organs to strengthen royal power: a system to train future administrators in his own particular throne-centered interpretation of Confucianism, the ch’ogye munsin, and a locus of power outside the traditional bureaucratic ladder, the Royal Library. Chapter 5 addresses Chŏngjo’s military reforms. After gutting the established military organizations, he set up a new army under the command of his personally-selected governor in the city of Suwŏn, headquartered at the newly-constructed Illustrious Fortress. The sixth and final chapter concludes with an assessment of Chŏngjo’s reforms: He was largely successful in creating space for royal autonomy during his lifetime but was largely unsuccessful in perpetuating that power beyond his reign.
Diversification Strategies and Firm Performance: A Sample Selection Approach
Creators: name: Santarelli, Enrico
name: Tran, Hien Thu
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2013
Subjects: SECS-P/02 Politica economica

description: This paper is based upon the assumption that firm profitability is determined by its degree of diversification which in turn is strongly related to the antecedent decision to carry out diversification activities. This calls for an empirical approach that permits the joint analysis of the three interrelated and consecutive stages of the overall diversification process: diversification decision, degree of diversification, and outcome of diversification. We apply parametric and semiparametric approaches to control for sample selection and endogeneity of diversification decision in both static and dynamic models. After controlling for industry fixed-effects, empirical evidence from firm-level data shows that diversification has a curvilinear effect on profitability: it improves firms’ profit up to a point, after which a further increase in diversification is associated with declining performance. This implies that firms should consider optimal levels of product diversification when they expand product offerings beyond their core business. Other worth-noting findings include: (i) factors stimulating firms to diversify do not necessarily encourage them to extend their diversification strategy; (ii) firms which are endowed with highly skilled human capital are likely to successfully exploit diversification as an engine of growth; (iii) while industry performance does not influence profitability of firms, it impacts their diversification decision and degree.
Phases of Lagrangian-invariant objects in the derived category of an abelian variety
Creators: name: Polishchuk, Alexander
Publisher: name: arXiv
Year: 2012
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics

description: We continue the study of Lagrangian-invariant objects (LI-objects for short) in the derived category $D^b(A)$ of coherent sheaves on an abelian variety, initiated in arXiv:1109.0527. For every element of the complexified ample cone $D_A$ we construct a natural phase function on the set of LI-objects, which in the case $\dim A=2$ gives the phases with respect to the corresponding Bridgeland stability (see math.AG/0307164). The construction is based on the relation between endofunctors of $D^b(A)$ and a certain natural central extension of groups, associated with $D_A$ viewed as a hermitian symmetric space. In the case when $A$ is a power of an elliptic curve, we show that our phase function has a natural interpretation in terms of the Fukaya category of the mirror dual abelian variety. As a byproduct of our study of LI-objects we show that the Bridgeland's component of the stability space of an abelian surface contains all full stabilities.
description: 49 pages; v2: added the proof of the fact that the Bridgeland's component of the stability space of an abelian surface contains all full stabilities
Untersuchungen zum Einfluss von Schwangerschaftshormonen und Alpha-Fetoprotein auf IL-10-produzierende B-Zellen in der Schwangerschaft
Creators: name: Fettke, Franziska
Publisher: name: Otto-von-Guericke-Universität Magdeburg
Year: 2021
Subjects: subject: Schwangerschaft
subject: B-Lymphozyt
subject: Hormon
subject: Fetoprotein alpha
subject: 573.67

description: Die menschliche Schwangerschaft stellt eine besondere Situation für das mütterliche Immunsystem dar, die in der aktiven Toleranz des zur Hälfte immunologisch fremden Fetus und der konstanten Reaktionsfähigkeit gegenüber Krankheitserregern besteht. IL-10-produzierende B-Zellen treten als neue Akteure der mütterlichen Toleranzmechanismen auf. Um physiologische Auslöser ihrer Expansion zu identifizieren, wurde in dieser Arbeit zunächst der Einfluss Trophoblast-abgeleiteter Faktoren auf die Fähigkeit von B-Zellen IL-10 zu produzieren untersucht. Die Untersuchungen im Maussystem bestätigten, dass die Kultur von B-Zellen mit Trophoblastzellen bzw. Plazentagewebe die Generierung IL-10-produzierender B-Zellen unterstützt. Unter Verwendung humaner Proben wurde der Einfluss Trophoblast-abgeleiteter Hormone, speziell des humanen Choriongonadotropin (hCG), Progesteron (P4) und Östradiol (E2), auf IL-10-produzierende B-Zellen untersucht. Die in-vitro-Versuche zeigten, dass hCG sowohl die Generierung IL-10-produzierender B-Zellen als auch die Produktion schwangerschaftsprotektiver asymmetrischer Antikörper (AAk) induziert. Die Ergebnisse unterstreichen die Schlüsselrolle des hCG auf B-Zell-assoziierte Toleranzmechanismen in der Schwangerschaft. Weiterführende Versuche zum Einfluss des vom Fetus selbst produzierten AFP konnten zudem zeigen, dass die Behandlung der B-Zellen mit AFP in hoher Konzentration die Apoptose der Zellen bewirkt. Die Ergebnisse deuten auf die Existenz fetaler Mechanismen hin, die den Eintritt potenziell schädlicher B-Zellen in den fetalen Organismus regulieren. Die in der vorliegenden Arbeit gewonnenen Erkenntnisse tragen zum Verständnis der mütterlichen und fetalen Toleranzmechanismen in der Schwangerschaft bei. Sie bilden die Grundlage für die Entwicklung therapeutischer Ansätze zur Behandlung von Schwangerschaftskomplikationen, die auf einer immunvermittelten Abstoßung des Fetus basieren.
DEM simulation and analysis of operating parameters on grinding performance of a vertical stirred media mill
Creators: name: Hou, Yu
Publisher: name: University of British Columbia
Year: 2014

description: Stirred media mills have been increasingly used in ultra-fine grinding. The VXPmill is a vertical high speed stirred media mill for grinding mineral ores with high efficiency. Since it is a new technology in the industry, there is little understanding on the breakage kinetics of the mill. In order to gain more knowledge about the VXPmill, computer modelling of the mill was performed. Laboratory grinding trials were also conducted on a pilot scale mill to provide more information about the mill’s capability, as well as verify simulation results. DEM (Discrete Element Method) is a powerful tool in predicting particle behaviour, which is ideal for the study of stirred media milling. The CFD (Computational Fluid Dynamics) is used to model the motion of slurry by numerically solving the Navier–Stokes equations facilitated with the Volume of Fluid (VOF) and multiphase flow models. Simulation results suggested that a velocity gradient exists in the fluid field and grinding media in the mill. The highest grinding media velocity was reached near the disc edge in the horizontal direction and near the bottom of the mill in vertical direction. Those are the most active grinding zones in a vertical stirred mill. Different operating parameters such as stirrer rotational speed, slurry solid content and slurry viscosity have an influence on mill performance. Simulation results show that operating the mill at a high impeller speed helps to improve mineral liberation, while at too high impeller speed leads to a waste of electric energy without much improvement in mineral liberation. As well, a mid-level slurry solid content (15% v/v to 30% v/v) was found to achieve the best energy utilization during grinding. The slurry viscosity should be kept low to minimize the effect of high shear stress in the slurry. The influence of various operating parameters can be combined into the ‘stress intensity’ which describes the capability of a stirred media mill. Operating parameters also have an influence on the magnitude of force magnitude between grinding media which will result in different breakage mechanism. Fracture breakage mechanism plays a more important role than attrition in VXPmill.
Additional file 4: of Prevalence and income-related equity in hypertension in rural China from 1991 to 2011: differences between self-reported and tested measures
Creators: name: Cao, Dan
name: Zhou, Zhongliang
name: Si, Yafei
name: Xiao, Xiao
name: Wang, Xiao
name: Shen, Chi
name: Ren, Yangling
name: Su, Min
name: He, Shuyi
name: Gao, Jianmin
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Table S3. The regression effect of 1991, 1993 and 1997. Table S4. the regression effect of 2000, 2004, 2006 and 2009. (PDF 238 kb)
Robustness Leads Close to the Edge of Chaos in Coupled Map Networks: toward the understanding of biological networks
Creators: name: Saito, Nen
name: Kikuchi, Macoto
Publisher: name: arXiv
Year: 2012
Subjects: subject: Molecular Networks (q-bio.MN)
subject: Populations and Evolution (q-bio.PE)
subject: FOS: Biological sciences

description: Dynamics in biological networks are in general robust against several perturbations. We investigate a coupled map network as a model motivated by gene regulatory networks and design systems which are robust against phenotypic perturbations (perturbations in dynamics), as well as systems which are robust against mutation (perturbations in network structure). To achieve such a design, we apply a multicanonical Monte Carlo method. Analysis based on the maximum Lyapunov exponent and parameter sensitivity shows that systems with marginal stability, which are regarded as systems at the edge of chaos, emerge when robustness against network perturbations is required. This emergence of the edge of chaos is a self-organization phenomenon and does not need a fine tuning of parameters.
description: 14 pages, 5 figures
DESIGN DE INTERIORES: ESTILO MONTESSORI NOS DIAS ATUAIS E SUA IMPORTÂNCIA
Creators: name: Ferreira, Andressa Unser Da Veiga
name: Duarte, Gabriela
name: Bortolato, Carlos
Publisher: name: Zenodo
Year: 2025
Subjects: design
interiores
estilo

description: O artigo propõe-se a explorar como o estilo Montessori, que valoriza o ambiente preparado e o respeito à individualidade, pode ser aplicado nos dias atuais, tanto em escolas quanto em residências. Também foi discutida a importância desse método para o desenvolvimento infantil, considerando os desafios e as necessidades da sociedade contemporânea, marcada pela tecnologia e pelo estímulo constante.
Bestimmung des Energiespektrums von atmosphärischen Myonneutrinos mit 3 Jahren Daten des IceCube-Detektors
Creators: name: Börner, Mathis
Publisher: name: TU Dortmund
Year: 2018
Subjects: subject: Astroteilchenphysik
subject: Neutrinoastronomie
subject: Maschinelles Lernen
subject: 530
subject: Myonneutrino
subject: Astrophysik
subject: IceCube
subject: Maschinelles Lernen

description: In dieser Arbeit wird die Messung des Energiespektrums atmosphärischer Myonneutrinos in einem Energiebereich zwischen 125 GeV und 2 PeV mit Daten des IceCube-Detektors vorgestellt. Zur Durchführung der Messung wurde zunächst für die drei untersuchten Messjahre ein Myonneutrinodatensatz erzeugt. Für den Datensatz wurde eine Reinheit von 99.7±0.03% bei einer Ereignisrate von 3.47 mHz erreicht. Die Ereignisrate liegt circa 35% höher als bei vergleichbaren Datensätzen der selben Messjahre. Für die Bestimmung des Spektrum wurde ein etablierter Entfaltungsansatz genutzt, der im Rahmen dieser Arbeit entscheidend weiterentwickelt wurde. Das erste Ergebnis ist eine Entfaltung mit 14 Messpunkten zwischen 125 GeV und 2 PeV in einem Zenitbereich zwischen 86° und 180°. Das Ergebnis zeigt ein mit den aktuellen Messungen des astrophysikalischen Flusses kompatibles Abflachen für Eν > 100 TeV. Zusätzlich wurde das Spektrum mit jeweils 11 Messpunkten zwischen 125 GeV und 250 TeV für 3 disjunkte Zenitbereiche entfaltet.
description: In this work the measurement of the energy spectrum of atmospheric muon neutrinos in an energy range from 125 GeV to 2 PeV with data of the IceCube detector is presented. To perform the measurement a muon neutrino sample was created from three years worth of data. The sample achieved a purity of 99.7±0.03% at an event rate of 3.47 mHz. The event rate is approximately 35% higher compared to similar samples created before from the same data. In the course of this analysis an established unfolding appraoch was significantly improved and applied to determine the energy spectrum. The first result is an unfolding with 14 data points between 125 GeV and 2 PeV in a zenith range between 86° and 180°. The result shows a flattening for Eν > 100 TeV compatible with the most recent measurements of the astrophysical flux. In addition, the spectrum was unfolded with 1 data points up to energies of 250 TeV for 3 disjoint zenith regions.
One-Dimensional Quantum Liquids: Beyond the Luttinger Liquid Paradigm
Creators: name: Imambekov, Adilet
name: Schmidt, Thomas L.
name: Glazman, Leonid I.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: For many years, the Luttinger liquid theory has served as a useful paradigm for the description of one-dimensional (1D) quantum fluids in the limit of low energies. This theory is based on a linearization of the dispersion relation of the particles constituting the fluid. We review the recent progress in understanding 1D quantum fluids beyond the low-energy limit, where the nonlinearity of the dispersion relation becomes essential. The novel methods which have been developed to tackle such systems combine phenomenology built on the ideas of the Fermi edge singularity and the Fermi liquid theory, perturbation theory in the interaction strength, and a new way of treating finite-size integrable models. These methods can be applied to a wide variety of 1D fluids, from 1D spin liquids to electrons in quantum wires to cold atoms confined to a 1D trap. We review existing results for various dynamic correlation functions, in particular the density structure factor and the spectral function. Moreover, we show how a dispersion nonlinearity leads to finite particle lifetimes, and discuss its impact on the transport properties of 1D systems at finite temperatures. The conventional Luttinger liquid theory is a special limit of the new theory, and we explain the relation between the two.
description: 61 pages, 18 figures, published version, minor typos corrected
Additional file 9 of Comprehensive analysis of the expression, prognostic significance, and function of FAM83 family members in breast cancer
Creators: name: Jin, Yi
name: Yu, Jiahui
name: Jiang, Yi
name: Bu, Jiawen
name: Zhu, Tong
name: Gu, Xi
name: Zhu, Xudong
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology
subject: Computational Biology

description: Additional file 9: Figure S9. The relationships between immune cell infiltration and the expression of FAM83A, FAM83D, FAM83F and FAM83G by “ESTIMATE” analysis tool.
Molekulare Charakterisierung von Hirnmetastasen als Erstmanifestation beim Lungenkarzinom
Creators: name: Hanke, Benjamin
Publisher: name: Otto-von-Guericke-Universität Magdeburg
Year: 2021
Subjects: subject: Lungenkrebs
subject: Hirnmetastase
subject: 616.99407

description: Tumoren der Lunge gehören zu den häufigsten Todesursachen und nehmen unter den Krebstodesfällen in Deutschland Platz 1 (Männer) bzw. Platz 2 (Frauen) ein. Zusätzlich zur primären Tumorerkrankung treten häufig Metastasen auf. Diese können gleichzeitig mit der Diagnose des Primärtumors (synchron) oder im Verlauf der Erkrankung (metachron) auftreten. Die vorliegende Arbeit beschäftigt sich mit Metastasen eines Lungenkarzinoms im zentralen Nervensystem (ZNS), die erstmals über eine neurologische Symptomatik auffällig wurden. Zum Zeitpunkt der Resektion war also noch kein Primärtumor bekannt. Über dieses Patientenkollektiv lagen bisher nur spärlich molekulare Daten zu Metastasen im zentralen Nervensystem vor. Es wurden 33 Patienten in dieser Studie untersucht (23 Männer, 10 Frauen). Das Tumormaterial wurde konventionell-histologisch sowie molekularpathologisch untersucht. Zudem erfolgte eine Analyse klinischer sowie radiologischer Patienteninformationen. Histologisch fanden sich überwiegend Adenokarzinome (73%), die übrigen Metastasen stammten von kleinzelligen Lungenkarzinomen (27%). 27 Metastasen lagen supratentoriell (82%) und 6 Metastasen (18%) infratentoriell. Bei der überwiegenden Mehrheit der Patienten fanden sich singuläre Metastasen (85%), ansonsten lagen multiple Hirnmetastasen vor (15%). Auf molekularer Ebene fanden sich in 16% der untersuchten Proben der Metastasen KRAS-Mutationen, 9% der Tumoren wiesen EGFR-Mutationen auf. Es wurden 5 FGFR1-Amplifikationen gefunden (16%), diese waren signifikant mit einem erhöhten Metastasenvolumen vergesellschaftet. Darüber hinaus fanden sich 8 MET-Amplifikationen (27%). Translokationen von EML4/ALK, ROS1 bzw. RET wurden nicht beobachtet. Die vorliegende Arbeit erweitert das Verständnis molekularer Veränderungen bei Patienten mit ZNS-Metastasen als Erstmanifestation eines Lungenkarzinomes.
Strict local martingales and bubbles
Creators: name: Kardaras, Constantinos
name: Kreher, Dörte
name: Nikeghbali, Ashkan
Publisher: name: arXiv
Year: 2011
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics

description: This paper deals with asset price bubbles modeled by strict local martingales. With any strict local martingale, one can associate a new measure, which is studied in detail in the first part of the paper. In the second part, we determine the "default term" apparent in risk-neutral option prices if the underlying stock exhibits a bubble modeled by a strict local martingale. Results for certain path dependent options and last passage time formulas are given.
description: Published at http://dx.doi.org/10.1214/14-AAP1037 in the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Lembit Põlma välipäevik nr 5
Creators: name: Põlma, Lembit
Publisher: name: Tallinna Tehnikaülikooli Geoloogia Instituut
Year: 1980
Subjects: Ordoviitsium
Eesti
puuraugud
geoloogilised kirjeldused
Ordovician
drill cores
Estonia
geological descriptions

description: Field notebook with descriptions of Ordovician drill cores in Estonia (1980-82).
4. War, Empire, and Republic in Revolutionary Europe. A Review-Interview with R. Whatmore
Creators: name: Albertone, Manuela
Publisher: name: GISI - UniTO
Year: 2012

description: Richard Whatmore’s last book provides an interdisciplinary approach in intellectual history that centers around some political and economical issues debated in the last decades of the eighteenth-century. The story of how the Genevan représentants tried to preserve the independence of their city in the face of the power of France and Britain is investigated as a case study to set out the dialectic between small and large states in the last years of the Old regime and during the revolutionary period, as well as the role of free trade in indicating the path to reorganise international relationships. Some of the main arguments and conclusions of the book are discussed here with the author: a modern republicanism and its economic foundations, tension between democracy and republicanism, a new stress on the political implications of Physiocracy, an innovative idea of empire investigated from the perspective of continental Europe. The author, Director of the Sussex Centre for Intellectual History, also discusses with us the interdisciplinary characteristics of the current main trends of intellectual history in Britain.
description: Journal of Interdisciplinary History of Ideas, Vol 1, No 2 (2012)
A classification of bisymmetric polynomial functions over integral domains of characteristic zero
Creators: name: Marichal, Jean-Luc
name: Mathonet, Pierre
Publisher: name: arXiv
Year: 2011
Subjects: subject: Rings and Algebras (math.RA)
subject: FOS: Mathematics
subject: 13B25, 26B35, 39B72

description: We describe the class of n-variable polynomial functions that satisfy Aczél's bisymmetry property over an arbitrary integral domain of characteristic zero with identity.
A note on the real part of the Riemann zeta-function
Creators: name: de Reyna, Juan Arias
name: Brent, Richard P.
name: van de Lune, Jan
Publisher: name: arXiv
Year: 2011
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11M06 (Primary) 11-04 (Secondary)

description: We consider the real part $\Re(ζ(s))$ of the Riemann zeta-function $ζ(s)$ in the half-plane $\Re(s) \ge 1$. We show how to compute accurately the constant $σ_0 = 1.19\ldots$ which is defined to be the supremum of $σ$ such that $\Re(ζ(σ+it))$ can be negative (or zero) for some real $t$. We also consider intervals where $\Re(ζ(1+it)) \le 0$ and show that they are rare. The first occurs for $t$ approximately 682112.9, and has length about 0.05. We list the first fifty such intervals.
description: 8 pages, 1 table; In "Herman J. J. te Riele Liber Amicorum", CWI, Amsterdam, December 2010. Eqn. (4) corrected in v2
Betulinsulfonamide als Prodrug gegen hypoxische Tumoren
Creators: name: Emmerich, Daniel
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 540

description: In dieser Arbeit sollten Wirkstoffe hergestellt werden, die die Apoptose auslösenden Eigenschaften von Betulin und Betulinsäure mit der Fähigkeit von Sulfonamiden zur Inhibierung von Carboanhydrasen kombinieren, um in zweifacher Weise gegen hypoxische Tumorzellen vorzugehen. Es wurden verschiedene solcher Verbindungen synthetisiert und charakterisiert, einschließlich einfacher Sulfamate der Triterpene sowie Taurinamidverbindungen, welche über Spacer an Betulin gebunden sind. 26 dieser Stoffe wurden noch nicht in der Literatur beschrieben. Von den hergestellten Stoffen wurde die Antitumoraktivität gegen verschiedene Krebszelllinien mittels SRB-Tests ermittelt und gegen einen murinen Fibroblasten auf ihre Selektivität hin untersucht. Aus den Zytotoxizitätsuntersuchungen ließen sich Struktur-Wirkungs-Korrelationen gegen einige der Zelllinien ermitteln. Die Linie HT29 zeigte dabei ein anderes Wirkprofil als die anderen untersuchten Linien.
description: The purpose of this work was to prepare substances combining the apoptosis-inducing properties of betulin and betulinic acid with the inhibitive effect of sulfonamides towards carbonic anhydrases in order to treat hypoxic tumor cells in a twofold way. Various such compounds were synthesized, including simple sulfamates of the triterpenoids as well as taurinamide-based compounds which are connected to betulin via a spacer. 26 of these substances previously hadn't been described in the literature. The antitumor activity of the substances was determined versus various cancer cell lines by use of SRB assays, and their selectivity was calculated based on their effect on a murine fibroblast. Structure-activity relationships for some of the cell lines could be developed from the cytotoxicity assays. Here, the line HT29 showed a different behavior than the other examined cell lines.
5. Book Reviews
Creators: name: Carnino, Cecilia
name: Mammola, Simone
name: Pasini, Enrico
Publisher: name: GISI - UniTO
Year: 2012

description: Reviews of J. Astigarraga, Luces y republicanismo. Economía y politica en las Apuntaciones al Genovesi de Ramón de Salas, Centro de Estudios Políticos y Constitucionales, 2011; M. Bucciantini, M. Camerota, F. Giudice, Il telescopio di Galileo. Una storia europea, Einaudi, 2012; F. Falk, Eine gestische Geschichte der Grenze. Wie der Liberalismus an der Grenze an seine Grenzen kommt, Wilhelm Fink, 2011.
description: Journal of Interdisciplinary History of Ideas, Vol 1, No 2 (2012)
The role of antibody testing for anti-natalizumab and anti-aquaporin-4 antibodies in demyelinating disorders
Creators: name: Fronda, Anna Grace
Publisher: name: University of British Columbia
Year: 2014

description: Antibody testing in medicine is utilized for diverse purposes that are highly dependent on the type of antibody and the disease to which it is related. This thesis examines testing for antibodies in relation to two demyelinating diseases of the central nervous system. Anti-natalizumab antibodies in multiple sclerosis (MS) patients treated with natalizumab, a therapeutic humanized monoclonal antibody against a cell adhesion protein, are associated with increased infusion-related reactions and reduced treatment efficacy. While initial testing for this anti-biological antibody is recommended before 24 weeks of treatment, a seropositive result warrants multiple testing throughout the treatment duration to distinguish transient from persistent antibody responses. This is significant because patients with a transient antibody response may still benefit from natalizumab treatment in the long term whereas patients with persistent antibodies will not and, therefore, should discontinue treatment. A Biacore assay for anti-natalizumab antibodies that uses surface plasmon technology is suitable for a large amount of samples and to study antibody affinity. As such, this assay was used to demonstrate that in a single patient with a transient antibody response, seroconversion to antibody negative is indicative of immune tolerance to natalizumab. The second antibody under investigation is the pathological autoantibody, anti-aquaporin-4 antibody. It is the most specific and sensitive serum biomarker for neuromyelitis optica (NMO) and NMO spectrum disorders. However, there is, at present, a lack of standardization with the currently available methods to measure this antibody. This is seen in the varying assay senstitivity and specificities between labs even with commercial assays, as well as the differing results with repeat testing of samples. Along with the formulation of diagnostic criteria that better distinguishes NMO from MS, an effort should be made to improve current immunoassays and to development more sensitive techniques to measure anti-aquaporin-4 antibodies in patient serum.
Elucidating mechanisms of unreduced gamete formation in Arabidopsis thaliana
Creators: name: Piskorz, Ewa Weronika
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 2022
Subjects: subject: 576

description: Die Meiose ist für die sexuelle Fortpflanzung unerlässlich, und Anomalien in diesem Prozess führen oft zu Polyploidie. Während der männlichen Meiose in Arabidopsis wird das JASON (JAS)-Protein benötigt, um das „Organellenband“ aufrechtzuerhalten, das eine physikalische Barriere für zwei sich trennende Chromosomengruppen in der Metaphase II darstellt. Der Verlust dieser Struktur in der jas-Mutante führt zu einer abnormalen Spindelpositionierung, einer falschen Chromosomensegregation und der Bildung unreduzierter (2n) Gameten. Um die Mechanismen der unreduzierten Gametenbildung weiter zu untersuchen, wurde ein Suppressor-Screen durchgeführt, um Mutanten zu finden, die reduzierte (1n) Gameten in Gegenwart einer jas-Mutation bilden. Unter Verwendung des Vorwärts-Genetik-Ansatzes habe ich eine starke Mutante, peleus, identifiziert und charakterisiert, die die 2n-Gametenbildung durch teilweise Wiederherstellung der Organellenbande unterdrückt. Eine weitere genetische und zytologische Analyse der jas;pel-Doppelmutante wies auf die Beteiligung des Aktin-Zytoskeletts, des Endomembransystems und des Proteinabbauwegs an der Regulation der meiotischen Progression hin.
description: Meiosis is essential for sexual reproduction and abnormalities in this process often lead to polyploidy. During male meiosis in Arabidopsis, JASON (JAS) protein is required for maintaining the “organelle band”, which provides a physical barrier for two segregating chromosome groups at metaphase II. Loss of this structure in the jas mutant leads to abnormal spindle positioning, incorrect chromosome segregation and formation of unreduced (2n) gametes. To further investigate the mechanisms of unreduced gamete formation, a suppressor screen was performed, aimed to find mutants that form reduced (1n) gametes in the presence of jas mutation. Using forward genetics approach, I have identified and characterized a strong mutant, peleus, that was able to suppress 2n gamete formation through partial recovery of the organelle band. Further genetic and cytological analysis of jas;pel double mutant pointed to the involvement of actin cytoskeleton, endomembrane system and protein degradation pathway in the regulation of meiotic progression.
3. THE NATIONAL ACADEMIC UNCONSCIOUS IN QUESTION. HISTORY OF CONCEPTS, HISTORICAL SEMANTICS, CRITICAL SOCIOLOGY OF LEXICAL USAGE WITHIN THE SOCIAL SCIENCES
Creators: name: Christin, Olivier
Publisher: name: GISI - UniTO
Year: 2013

description: A few years ago, together with Franz Schultheis, of the University of Saint-Gallen and coordinator of the social sciences network ESSE, we chose to study the international circulation of the categories and concepts that are in use in European social sciences. With the publication of the Dictionnaire des concepts  nomades (“Dictionary of nomadic concepts”), that includes only a small number of quite lengthy entries, what we tried to propose were not ready-made solutions, or vademecums for the comparative academic, but a series of questions, or rather the means to ask crucial questions for anyone who practises history, political science, history of economic ideas, or comparative sociology. We did so with two considerations in mind: one political, and the other academic, both of which I will evoke in turn in this paper.
description: Journal of Interdisciplinary History of Ideas, Vol 2, No 1 (2013)
Geometry and Topology of some overdetermined elliptic problems
Creators: name: Ros, Antonio
name: Sicbaldi, Pieralberto
Publisher: name: arXiv
Year: 2012
Subjects: subject: Analysis of PDEs (math.AP)
subject: Differential Geometry (math.DG)
subject: FOS: Mathematics

description: We study necessary conditions on the geometry and the topology of domains in $\mathbb{R}^2$ that support a positive solution to a classical overdetermined elliptic problem. The ideas and tools we use come from constant mean curvature surface theory. In particular, we obtain a partial answer to a question posed by H. Berestycki, L. Caffarelli and L. Nirenberg in 1997. We investigate also some boundedness properties of the solution $u$. Some of our results generalize to higher dimensions.
Intrinsic galaxy shapes and alignments I: Measuring and modelling COSMOS intrinsic galaxy ellipticities
Creators: name: Joachimi, B.
name: Semboloni, E.
name: Bett, P. E.
name: Hartlap, J.
name: Hilbert, S.
name: Hoekstra, H.
name: Schneider, P.
name: Schrabback, T.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The statistical properties of the ellipticities of galaxy images depend on how galaxies form and evolve, and therefore constrain models of galaxy morphology, which are key to the removal of the intrinsic alignment contamination of cosmological weak lensing surveys, as well as to the calibration of weak lensing shape measurements. We construct such models based on the halo properties of the Millennium Simulation and confront them with a sample of 90,000 galaxies from the COSMOS Survey, covering three decades in luminosity and redshifts out to z=2. The ellipticity measurements are corrected for effects of point spread function smearing, spurious image distortions, and measurement noise. Dividing galaxies into early, late, and irregular types, we find that early-type galaxies have up to a factor of two lower intrinsic ellipticity dispersion than late-type galaxies. None of the samples shows evidence for redshift evolution, while the ellipticity dispersion for late-type galaxies scales strongly with absolute magnitude at the bright end. The simulation-based models reproduce the main characteristics of the intrinsic ellipticity distributions although which model fares best depends on the selection criteria of the galaxy sample. We observe fewer close-to-circular late-type galaxy images in COSMOS than expected for a sample of randomly oriented circular thick disks and discuss possible explanations for this deficit.
description: 18 pages, 8 figures; updated simulations and galaxy sample definition, more galaxy samples analysed; matches version published in MNRAS
Additional file 3: of Optic nerve as a source of activated retinal microglia post-injury
Creators: name: Heuss, Neal
name: Pierson, Mark
name: Roehrich, Heidi
name: McPherson, Scott
name: Gram, Andrea
name: Li, Ling
name: Gregerson, Dale
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Immunology
subject: FOS: Clinical medicine
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Figure S3. Although the naive NFL/RGC was sparsely populated with microglia (Manuscript Fig. 5), optical sections from slightly deeper than the NFL/RGC revealed many CX3CR1-YFP+ cells. Our interpretation was that we had penetrated into the IPL, consistent with the remaining small area of faint magenta staining for β3-tubulin in the upper right quadrant. Counts from the NFL/RGC and IPL revealed substantial differences in microglia numbers in naive retina (Note Manuscript Fig. 6). Yellow = CX3CR1-YFP; Magenta = β3-tubulin. (DOCX 1183 kb)
A Simple Proposal for a Solution to the Accommodation-Vergence Mismatch Problem in 3D Displays
Creators: name: Kim, Dal-Young
Publisher: name: arXiv
Year: 2011
Subjects: subject: Optics (physics.optics)
subject: Biological Physics (physics.bio-ph)
subject: Other Quantitative Biology (q-bio.OT)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Here is suggested a solution to the accommodation-vergence mismatch problem in 3D stereoscopic displays. It can be achieved by compensating the mismatched focal length with refractive power of adjustable-focus 3D glasses. The compensation would make vergence of human eyes match with position of virtual stereoscopic motion pictures, reducing visual fatigue.
description: Presented as a poster at IMID 2012 (The 12th International Meeting on Information Display, 28-31 Aug 2012, EXCO, Daegu, Korea)
D6.7: Validation Report
Creators: name: Anastasiou, Vangelis
name: Zisis Tsiropoulos
name: Fountas, Spyros
name: Protic, Dragutin
name: Perperidou, Dimitra
Publisher: name: Zenodo
Year: 2019

description: The deliverable at hand – the Validation Report – provides an overview of the whole activities that carried out for evaluation and validationin the course of the APOLLO project at the locations of the three pilot areas and presents results and findings. The Validation Report consists of sixchapters:

	In the first chapter, the reasoning for conducting an evaluation survey for achieving user’s acceptance is analysed.
	In the second chapter, there is a brief reference to validation results that are used in APOLLO added value services with main focus on the yield product validation.
	The third chapter refers to the use of the APOLLO added value service in terms of crops, area covered and number of APOLLO services users.
	In the fourth chapter, a brief report on the evaluation of added value services is provided and especially for the evaluation results on tillage and irrigation scheduling services.
	The fifth chapter refers to the online questionnaire and interview results on the acceptance of the APOLLO added value services by the alpha and beta users.
	In the sixth and final chapter, there is the conclusion of the overall performance of the APOLLO platform and added value services during the evaluation period of the APOLLO project.