cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Characterisation of heteromeric 5-HT₃ receptors: a focus on the 5-HT₃C and 5-HT₃E subunits
Creators: name: Yaakob, Nor Syafinaz
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: 5-HT₃ receptors are ligand-gated cation channels present in both central and peripheral nervous systems. 5-HT₃ receptor antagonists are used clinically for a range of disorders including irritable bowel syndrome, chemotherapy-induced nausea and depression but have varying efficacy. 5-HT₃ receptors potentially contain five different subunits (A, B, C, D and E) that may contribute to the variability in efficacy. Inter-species variations in expression pattern of the subunit have also been reported including in human and rodents. The present study was aimed to characterise the expression, functional and pharmacological profiles of human 5-HT₃ receptors containing C and/or E subunits. Quantitative real-time PCR of human colon and ileum tissue was used to determine mRNA expression for all 5-HT₃ receptor subunits. Development of cloning strategies to optimize expression of heteromeric 5-HT₃ receptors in HEK293T cells preceded the functional and pharmacological experiments using whole cell patch clamping. The overall expression pattern of the C subunit did not vary significantly from A and B subunits in both human colon and ileum layers and regions. However the E subunit was found predominantly in mucosa of colon and ileum but not muscle layers. Only subtle changes were seen in the electrical properties of cells expressing 5-HT₃A, 5-HT₃AC, 5-HT₃AE, or 5-HT₃ACE subunits shown by whole cell recordings. The tri-heteromeric 5-HT₃ACE receptor was significantly inhibited by ondansetron and palonosetron. Most notably, palonosetron exerted faster inhibition on tri-heteromeric 5-HT₃ACE receptor compared to its homomeric and di-heteromeric counterparts. The mutant 5-HT₃A+C[N163K] receptor produced a significantly larger peak amplitude in response to 30µM 5-HT compared to the wild-type, but no significant difference on the relative response to ondansetron and palonosetron were observed. The widespread distribution of the C and E subunits throughout the human colon suggest that they may contribute to physiological functions. The predominant location of the E subunit in the mucosa could make it a potential therapeutic target. Patch-clamp experiments indicate that C and/or E subunits in heteromeric receptors may alter efficacies of 5-HT and clinically used antagonists such as palonosetron, which deserve further exploration to gain greater insights to improve current therapeutic applications of 5-HT₃ receptor antagonists including personalized therapies.
Metaphor and agency in the English-Spanish translation of texts in the social sciences
Creators: name: González, Jeffrey Marcelino
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: This doctoral thesis contains two parts: a critical exegesis in English and a scholarly translation in Spanish. With the latter comprising a book-length collection of essays from Contrary Notions. The Michael Parenti Reader (2007), this study seeks to contextualize Parenti’s work within the global translation market; additionally, it examines the researcher’s translation of Russell Crandall’s Gunboat Democracy: U.S. Interventions in the Dominican Republic, Grenada and Panama (2006), published in Spanish as Democracia a la fuerza. Intervenciones estadounidenses en la República Dominicana, Granada y Panamá (2011). Involving process- and product-oriented issues in two English-to-Spanish book translations in the social sciences, this study focuses on the rendering of metaphor and other stylistic devices, while delving into the role of the translator in replacing, via a text-holistic strategy of compensation, sentence-level loss with book-length gains. Additionally, in the context of the researcher’s own second-language (L2) translations, it seeks to challenge underlying assumptions regarding first-language (L1) translation and the privileged status it holds with regard to directionality and argues that, when it comes to identifying L1 and L2 proficiency in the context of translation, the intricacies involved require nuanced approaches, leaving little or no room for facile prescriptions of a binary nature. Further, this study examines the translator’s agency and collaborative-intervenient role as writer and researcher in producing, with authorial consent, bibliographically-expanded texts to meet target-culture expectations regarding scholarly work with local implications. Drawing from this researcher’s extensive communications with publishers in relation to the Crandall source and target texts, this study also examines, within the framework of agency, the translator’s role as de-facto literary agent from project conception and proposal submissions to peritextual production and rights-related negotiations. In short, this thesis represents a practice-led case study on translating scholarly non-fiction—challenges posed, strategies developed and agency wielded in creating Spanish versions of two books in the social sciences.
ปัจจัยทางสังคมกับการใช้ความรุนแรงทางเพศในประเทศไทย
Creators: name: อัคริมา สุขดี
Publisher: name: กองบริหารการวิจัย
Year: 2565
Subjects: ความรุนแรงทางเพศ
การข่มขืน
ปัญหาสังคม

description: วารสารธรรมศาสตร์, 41, 1, 161-177
latest on lameness treatments for practicing veterinarians
Creators: name: Cramer, Gerard
Publisher: name: American Association of Bovine Practitioners  Conference Proceedings
Year: 2022
Subjects: lameness
hoof lesions
treatment

description: As a recent graduate, treating lame cows can be a practice growth opportunity that allows you to show your clinical acu­men and be a gateway to providing more consultative services as part of a foot health team. To seize this practice growth op­portunity, practitioners need to have a clear understanding of the diagnosis and treatment of common foot disorders. Current treatment strategies are not overly complex, however, the ma­jority lack large-scale scientific evidence leading to a variety of opinions and approaches among stakeholders. There are some key principles that should be considered when treating lame cows to reduce pain as soon as possible and to prevent chronic­ity. These key principles include early and appropriate inter­vention and appropriate aftercare. Practitioners who seize this opportunity will become a valuable part of a farm’s team and greatly improve the welfare of cattle.
description: American Association of Bovine Practitioners Conference Proceedings, 2022 Recent Graduate Conference Proceedings
Additional file 1: of New anthropometric indices or old ones: which perform better in estimating cardiovascular risks in Chinese adults
Creators: name: Wang, Fei
name: Chen, Yintao
name: Chang, Ye
name: Sun, Guozhe
name: Sun, Yingxian
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: Health Questionnaire(2012). The questionnaire used in our study was developed for this study. (PDF 124Â kb)
Additional file 2: Table S2. of Stimulatory effect of icariin on the proliferation of neural stem cells from rat hippocampus
Creators: name: Fu, Xiaolong
name: Li, Shujun
name: Zhou, Shaoyu
name: Wu, Qin
name: Jin, Feng
name: Shi, Jingshan
Publisher: name: figshare
Year: 2018
Subjects: Pharmacology
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Developmental Biology
Science Policy

description: Raw data for Fig. 4. (DOCX 18 kb)
Sexual assault and the Catholic Church: are victims finding justice?
Creators: name: Courtin, Judith Edwina
Publisher: name: Monash University
Year: 2019
Subjects: Uncategorized

description: Over the last two to three decades in Australia, and internationally, there has been increasing exposure of institutional child sex crimes within the Catholic Church which has prompted demands for justice. In 2012, the Victorian Parliamentary Inquiry into the Handling of Child Abuse by Religious and Other Non-government Organisations was established as was a commission of inquiry into the Maitland-Newcastle Diocese in New South Wales. At the end of 2012, a national Royal Commission was set up to investigate child sexual assaults in government and non-government institutions, including the Catholic Church. This doctoral thesis commenced two years before these inquiries. It is a qualitative empirical study and case law analysis that sets out to determine whether victims of Catholic clergy sexual abuse in Australia are finding justice. To tackle this line of investigation, 70 people from Victoria and New South Wales, including primary and secondary victims, were interviewed about their experiences with civil litigation, criminal prosecutions and the Catholic Church’s internal complaints processes. In order to determine whether victims had found justice within these processes, a preliminary question needed to be addressed: ‘What is justice for these people?’ This latter line of inquiry identified seven critical criteria for justice for victims. These criteria were employed ultimately to evaluate the three pathways to justice, as outlined above. The findings of this research demonstrate that victims of clergy sexual abuse interviewed in this research are not finding justice. Further, those victims who attended the Church’s internal complaints processes, the Melbourne Response and Towards Healing, as well as not finding justice, suffered additional abuse and harm. The thesis concludes by outlining the significance of these findings and the types of reforms necessary to effectively address the justice needs of victims and their families, as identified in this research.
Catalytic steam gasification of biomass over nickel based catalysts via reactive flash volatilisation
Creators: name: Chan, Fan Liang
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Biomass gasification is a promising technology for delivering renewable energy. However, tar formation remains one of the main challenges. This research aims to develop in-situ nickel based catalysts for reactive flash volatilization (RFV) of biomass. RFV is a catalytic gasification process which uses high carbon space velocity and mass flow rate, with oxygen and steam as gasification agents, to produce tar free synthesis gas from non-volatile feedstock in a milliseconds residence time reactor. Ni, Pt-Ni, Ru-Ni, Re-Ni and Rh-Ni supported catalysts were investigated in this study. Effects of various operating parameters on the product selectivity (gas, tar and char) and syngas composition were evaluated. The operating parameters studied here include catalyst promoter, reaction temperature, carbon to oxygen feed ratio (C/O), carbon to steam feed ratio (C/S) and biomass ash content. Products were analysed using gas chromatography, total organic carbon (TOC) and CHNS/O analyses. Catalysts were characterised using Temperature Programmed Reduction, Temperature Programmed CO-Desorption, Transmission Electron Microscopy, nitrogen physisorption, X-ray Fluorescence and Powder X-ray Diffraction. Re-Ni, Rh-Ni and Ru-Ni, in that order, exhibited higher gasification efficiency in RFV of cellulose. This can be attributed to these catalysts’ higher reducibility and active metal surface area, and better coke resistance. Highest gasification efficiency was achieved at 750°C with C/O of 0.6 and C/S of 1.0, without any oxygen breakthrough. Kinetics study using a wire-mesh isothermal thermogravimetric analyser was conducted to investigate the role of catalyst in RFV. Result was modelled using a pseudo first order reaction model. Three distinct regimes of rate of mass loss were identified: pyrolytic decomposition, reforming and char gasification. Catalysts increased the rate of mass loss in reforming regime and improved the quality of synthesis gas. Rate of pyrolytic decomposition of lignocellose was found to be limited by devolatilisation of crystalline cellulose. Gasification efficiencies of pinewood and eucalyptus sawdust were found to be higher than cellulose under similar reaction conditions. Higher gas selectivity and lower char selectivity during pinewood and eucalyptus sawdust RFV was a result of more amorphous structure of lignocellulose compared to microcrystalline cellulose, and the catalytic effects of alkali and alkaline earth metals (AAEM) found in the lignocellulose ash. The catalytic effects of AAEM further reduced the coke deposition on the Ni catalysts, making the effect of noble metal promoter on the Ni catalysts less significant. Future studies may reduce the loading of noble metal to make RFV more economical.
การพัฒนาตัวบ่งชี้การเป็นผู้สนับสนุนการตลาดกีฬาขององค์กรธุรกิจในประเทศไทย
Creators: name: ปริญ ลักษิตามาศ
Publisher: name: กองบริหารการวิจัย
Year: 2565
Subjects: ตัวบ่งชี้
การเป็นผู้สนับสนุนการตลาดกีฬา
องค์กรธุรกิจในประเทศไทย

description: วารสารธรรมศาสตร์, 41, 1, 178-200
Dairy consulting 101
Creators: name: Costello, Nicole
Publisher: name: American Association of Bovine Practitioners  Conference Proceedings
Year: 2022
Subjects: consulting
new service
value added

description: “Consulting” is a highly sought-after area of expertise for many young veterinarians that is often ill-described and lacking di­rection. There are many different avenues to take in becoming a consultant, none of which are more correct than any other. A mindset shift combined with solid mentorship and a willing­ness to listen may be all it takes to adding consultative services to your clinic’s repertoire. A successful consultant will be ex­tremely passionate in their chosen area of expertise, will have a well-designed learning process, an understanding of the cost and return on investment, and will have developed several rough drafts along the way. This particular veterinarian will discuss in detail her process for developing a herd metrics con­sultative service for the clients in her practice area.
description: American Association of Bovine Practitioners Conference Proceedings, 2022 Recent Graduate Conference Proceedings
Leading relationships through change
Creators: name: Boyum, Brett
Publisher: name: American Association of Bovine Practitioners  Conference Proceedings
Year: 2022
Subjects: change
management
leadership

description: The goal of many consulting veterinarians in dairy and beef practice is to work toward continual improvement of their cli­ents’ health, management and overall business success. Such improvements will require changes to current management practices and strategy to adapt to changing market demands, herd dynamics or other external factors. This may feel like a constant state of change. However, our farm has had success in managing and implementing change through being cognizant of the Kübler-Ross Change Curve. This is a process to consider when implementing a successful change, regardless of the mag­nitude of change. Additionally, there are common pitfalls to avoid when fully executing a change. Following a disciplined change process will often yield a faster cycle of change and more desirable results. anish Language, Literature, and Culture from Colorado State University and a B.A. degree in Dramatic Arts from the University of New Mexico. She specializes in designing and teaching courses in Spanish for Specific Purposes in the areas of animal health and care and veterinary medicine and has created and taught Spanish programs for Colorado State University's Languages, Literatures and Cultures department as well as their Veterinary College since 2016. 
description: American Association of Bovine Practitioners Conference Proceedings, 2022 Recent Graduate Conference Proceedings
การรับรู้นิยามความหมายของอีสปอร์ตในสังคมไทยกับความคิดเห็นของบุคคล ทั่วไปต่อร่างพระราชบัญญัติการกำกับดูแลเกม และการประกอบกิจการเกม เพื่อคุ้มครองเด็ก และเยาวชน
Creators: name: อัศริยา ใจเย็น
Publisher: name: กองบริหารการวิจัย
Year: 2565
Subjects: อีสปอร์ต
การขัดเกลาทางสังคม
การรับรู้อีสปอร์ต

description: วารสารธรรมศาสตร์, 41, 1, 201-220
Additional file 3: Table S3. of Stimulatory effect of icariin on the proliferation of neural stem cells from rat hippocampus
Creators: name: Fu, Xiaolong
name: Li, Shujun
name: Zhou, Shaoyu
name: Wu, Qin
name: Jin, Feng
name: Shi, Jingshan
Publisher: name: figshare
Year: 2018
Subjects: Pharmacology
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Developmental Biology
Science Policy

description: Raw data for Fig. 5. (DOCX 25 kb)
ความขม: รสชาติกาแฟดำสู่ภาพสะท้อนรสชาติชีวิตทางสังคมของผู้บริโภค
Creators: name: สุมินตา แดงนาค
Publisher: name: กองบริหารการวิจัย
Year: 2565
Subjects: กาแฟดำ
ความขม
ชีวิตทางสังคม
คุณภาพชีวิต
วาทกรรม

description: วารสารธรรมศาสตร์, 41, 1, 221-241
บทบาทใหม่ของนักการศึกษาในโลกที่พลิกผัน
Creators: name: อาภาพร สิงหราช
Publisher: name: กองบริหารการวิจัย
Year: 2565
Subjects: เทคโนโลยีเปลี่ยนโลก
นักการศึกษา
การจัดการเรียนรู้

description: วารสารธรรมศาสตร์, 41, 1, 242-261
Different animal identification methods and application in disease outbreaks
Creators: name: White, Brad
Publisher: name: American Association of Bovine Practitioners  Conference Proceedings
Year: 2022
Subjects: cattle identification
disease outbreak

description: Individual animal identification can be useful for veterinarians to assist in management and prevention of disease outbreaks in cattle herds. Multiple methods exist for individually identifying cattle and the primary consideration matching the utility and ex­pense of the tag with the desired goal for identifying the animal. Animal disease traceability is an important aspect of regulatory veterinary medicine, and each practitioner plays a role in main­taining a consistent, safe supply of U.S. beef. Individual animal identification can be useful in managing a production-level disease outbreak to more rapidly identify commonality among affected cattle. One example of using data to make decisions is visualizing pregnancy distribution data to narrow differential diagnoses. Multiple methods of individual animal identification are available and veterinarians have an opportunity to work with their clients to capture value from a system to collect data.
description: American Association of Bovine Practitioners Conference Proceedings, 2022 Recent Graduate Conference Proceedings
On the thresholds and ceilings of advertising effects moderated by clutter and familiarity
Creators: name: De Canha, Nicholas Manuel
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: The effect of advertising on sales and market share is complex, as are the interactions between advertising and the environment in which it occurs. This study investigates the effect of advertising on sales, including providing unique contributions by quantifying threshold and ceiling levels of advertising effectiveness and providing an understanding of what affects those levels. Specifically, the study considers the effects of familiarity, market share and clutter on advertising effectiveness, and on those thresholds and ceilings, and quantifies the relative importance of each of these factors by combining them into a single model. The determinants of advertising goodwill decay are also considered. The study uses two methodologies: Data Envelopment Analysis and nonlinear regression, on a longitudinal (eight-year) data set of over 6,000 observations. Findings confirm the existence of ceiling and threshold effects whilst demonstrating the impact of clutter and familiarity. The share-of-voice / share-of-market relationship is re-examined in this context. The findings further demonstrate that the ceilings and thresholds are dependent on the level of clutter and familiarity. These findings extend the existing literature by providing evidence from the field (as opposed to previous laboratory-only studies), and by including several new variables (the Herfindahl Index, a measure of advertising concentration, and the difference between Share-of-Voice and market share) together with variables of clutter, familiarity and lag effects, simultaneously, in a single estimator function.
Additional file 4: Table S4. of Stimulatory effect of icariin on the proliferation of neural stem cells from rat hippocampus
Creators: name: Fu, Xiaolong
name: Li, Shujun
name: Zhou, Shaoyu
name: Wu, Qin
name: Jin, Feng
name: Shi, Jingshan
Publisher: name: figshare
Year: 2018
Subjects: Pharmacology
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Developmental Biology
Science Policy

description: Raw data for Fig.Â 6. (DOCX 19 kb)
Field necropsies – tips for all shapes and sizes
Creators: name: Homerosky, Elizabeth
name: Warr, Brian
Publisher: name: American Association of Bovine Practitioners  Conference Proceedings
Year: 2022
Subjects: necropsy
equipment
gross lesions
diagnostics

description: Field necropsies provide important information regarding both individual animal and herd health. Adequate preparation, including following an agreed-upon plan with the producer, obtaining proper equipment, and collecting a thorough his­tory, contributes significantly to successfully determining a diagnosis in a timely manner. Standard equipment includes proper outerwear, a necropsy knife, honing steel and an axe or reciprocating saw. Cattle should be placed left side down and prosected in a manner that allows the veterinarian to examine relevant organs in a consistent order. By developing a standard necropsy routine, the veterinarian is less likely to overlook or­gans with significant gross lesions. In the absence of distinctive gross lesions, submission of photographs or tissue samples to an experienced veterinarian or diagnostic laboratory may help with determination of the diagnosis or etiology.
description: American Association of Bovine Practitioners Conference Proceedings, 2022 Recent Graduate Conference Proceedings
The business of raising beef with welfare in the forefront
Creators: name: Barnhardt, Tera R.
Publisher: name: American Association of Bovine Practitioners  Conference Proceedings
Year: 2022
Subjects: cattle handling
animal welfare
consumer demand

description: Understanding consumer expectations of animal welfare and social responsibility can seem like a topic too broad for our producers to focus on while engrossed in the day-to-day opera­tions of farms. However, it’s paramount that producers under­stand that our consumers extend us a social license to operate our farms when displaying confidence in purchasing our prod­ucts. Furthermore, producers have a social responsibility to protect the brands of our largest consumers because they are often built on a specific beef product. Think about your favorite place to order a burger. They are very in tune with what their consumers’ preferences are and they purchase a lot of ground beef. We have a responsibility to this organization to protect their interest in the beef industry if we want them to continue purchasing beef raised and processed in the United States. If we are unable to do that, they will undoubtedly find an alterna­tive product, either through development or marketing, that the consumer will demand. With this responsibility in mind, veterinarians can work with producers on continuous improve­ment of animal welfare practices in order to maintain that con­fidence from consumers.
description: American Association of Bovine Practitioners Conference Proceedings, 2022 Recent Graduate Conference Proceedings
Additional file 2: Table S1. of Integrated omics data of two annual ryegrass (Lolium multiflorum L.) genotypes reveals core metabolic processes under drought stress
Creators: name: Pan, Ling
name: Meng, Chen
name: Wang, Jianping
name: Ma, Xiao
name: Fan, Xiaomei
name: Yang, Zhongfu
name: Zhou, Meiliang
name: Zhang, Xinquan
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Marine Biology
subject: Computational Biology

description: Detailed information of genes used for real-time-PCR analysis (DOCX 15 kb)
Feedlot rumen development from new calf to finish ration and working to avoid digestive disease as a veterinarian
Creators: name: Johnson, Blaine
Publisher: name: American Association of Bovine Practitioners  Conference Proceedings
Year: 2022
Subjects: feedlot
health
nutrition

description: Mitigating digestive mortalities begins when new cattle arrive. The proportion of U.S. feedlot mortalities attributable to di­gestive diseases accounts for 19.5% to 28.4% of all mortalities. Veterinarians provide a key role in the health and husbandry of cattle feeding operations. It is important to not overlook cer­tain aspects of cattle feeding such as water, rest and food for newly received cattle. Water plays a crucial role in an animal’s physiology/homeostasis. Rest from a stressful event, such as transportation, should be addressed prior to processing. A gen­eral industry recommendation for rest after transportation is one hour of rest for every hour of transportation. Food in the form of good-quality long-stem hay must be provided at arrival along with fresh water. The next phase is transitioning cattle to a high-grain diet. The transition period typically lasts around 28-45 days, which coincides with the highest risk period for bovine respiratory disease (BRD). Proper management during the transition phase relies on bunk management, reading the cattle, monitoring the weather and proper communication be­tween personnel working with and/or feeding the cattle. Fail­ure in one or more of these areas will likely result in undesir­able returns.
description: American Association of Bovine Practitioners Conference Proceedings, 2022 Recent Graduate Conference Proceedings
Immunosuppresive properties of peptidyl-fluoromethyl ketones and the role of oxidative stress in T cell activation and proliferation
Creators: name: Rajah, Tanuja
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: It is well established that caspases are involved in T cell activation and proliferation. Many of the early studies relied on peptidyl-fluoromethylketone (FMK) caspase inhibitors, such as z-VAD-FMK. Recently, z-VAD-FMK and z-IETD-FMK were shown to block T cell proliferation without inhibiting caspase activation. These results suggest that the inhibition of T cell proliferation by these peptidyl-FMK caspase inhibitors is independent of their caspase inhibition properties. In contrast, z-FA-FMK, commonly used as a negative control peptide for the FMK-containing caspase inhibitors, blocked T cell proliferation as well as inhibiting caspase processing. In the present study, several analogues of z-FA-FMK were examined to determine whether peptidyl-FMKs block mitogen-induced T cell activation and proliferation through the inhibition of specific targets or due to non-specific effects of the FMK group. The results showed that only z-FA-FMK blocks T cell proliferation whereas z-FA-diazomethylketone (DMK) has little effect while z-FA-chloromethylketone (CMK) was toxic and killed all the cells. This suggests that the FMK moiety may play an important role in blocking T cell activation and proliferation. Interestingly, replacing the alanine in z-FA-FMK with phenylalanine, z-FF-FMK, blocked T cell proliferation to a higher degree than z-FA-FMK. Similar to z-FA-FMK, z-FF-FMK inhibited T cell blast formation, CD25 and CD69 expression and cell cycle entry while inhibiting caspase processing in activated T cells. When peptidyl-methyl ketones were tested on Jurkat T cells, it was found that only z-FA-FMK and z-FF-MK blocked T cell proliferation. Next the mechanism of z-FA-FMK-, z-FF-FMK- and z-VAD-FMK-induced block of proliferation in primary and Jurkat T cells was examined. Several studies have shown that the cellular redox state plays an important role in T cell activation and proliferation. Thus, the effect of these three compounds on intracellular glutathione (GSH) levels and reactive oxygen species (ROS) generation was explored. The data showed that intracellular GSH was depleted while ROS generation was increased following treatment with the peptidyl-FMK inhibitors in primary and Jurkat T cells. The addition of the low molecular weight thiols GSH, N-acetylcysteine (NAC) and L-cysteine, readily reversed the inhibition of T cell proliferation induced by these peptidyl-FMK inhibitors, whereas D-cysteine, which cannot be metabolised to GSH had no effect. Furthermore, GSH, NAC and L-cysteine fully restored the caspase-8 and caspase-3 processing in anti-CD3-activated primary T cells treated with z-FA-FMK and z-FF-FMK. In conclusion, the results suggest that the immunosuppressive effect of z-FA-FMK, z-FF-FMK and z-VAD-FMK is likely due to the induction of oxidative stress and GSH depletion in T cells.
title: Research on renovation strategy of existing residential areas  in Shanghai from the perspective of residential satisfaction
Creators: name: Ni, Haozhan
name: He, Yong
name: Di, Yizhuo
name: Wu, Hao
Publisher: name: Conference Proceedings XXIX International Seminar on Urban Form ISUF 2022 Urban Redevelopment and Revitalisation A Multidisciplinary Perspective/Lodz University of Technology Press
Year: 2023
Subjects: Existing residential areas, Residential satisfaction, Renovation strategy.

description: The goal of this research is to look into the link between residential satisfaction and renovation strategy. This study involved 12 renovation measures, with 22 specific evaluation indicators, based on which generated a residential satisfaction questionnaire of existing residential areas in Shanghai. In this study, 215 questionnaires were gathered, with 184 of them being valid. Statistical tools, such as SPSS24.0, are used to determine the relationship between various renovation strategies and residential satisfaction. The results of the research reveal that the environmental renovation strategies have a low correlation with the overall living satisfaction of residents. However, renovation strategies in terms of housing renovation and supporting facilities renovation show a high correlation with the residence satisfaction.
MOESM1 of Processivity and enzymatic mechanism of a multifunctional family 5 endoglucanase from Bacillus subtilis BS-5 with potential applications in the saccharification of cellulosic substrates
Creators: name: Wu, Bin
name: Zheng, Shan
name: Pedroso, Marcelo
name: Guddat, Luke
name: Chang, Siyuan
name: He, Bingfang
name: Schenk, Gerhard
Publisher: name: figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 1: Figure S1. A The internal fragments of EG5C and EG5C-1 show significant homology to those of the endoglucanase from B. subtilis 168. Matched peptides of EG5C with those of endoglucanase from B. subtilis 168 are underlined with solid lines. The dotted lines indicate matched peptides of EG5C-1 with those of endoglucanase from B. subtilis 168. B Schematic structures of EG5C and its derivates. Figure S2. Multiple sequence alignment between EG5C and other family 5 endoglucanases from B. subtilis 168, B. subtilis A53, B. subtilis UMCT and B. amyoliquefaciens DL-3. Figure S3. Multiple sequence alignment of EG5C-1 and other family 5 processive endoglucanases or their catalytic domains. The following sequences have been included: catalytic domain of Cel5H from S. degradans, catalytic domain of ChCel5A from C. hutchinsonii, catalytic domain of Cel5C from H. chejuensis KCTC 2396, catalytic domain of Cel5A from uncultured Bacterium, catalytic domain of MtEG5A from M. thermophile, enzyme CHU_2103 from C. hutchinsonii, enzyme Cel5A from G. trabeum. CHU_2103 from C. hutchinsonii and Cel5A from G. trabeum were GH5 processive endoglucanase without CBM. Figure S4. A Solubilization of filter paper by EG5C and EG5C-1. B TLC analysis of soluble sugars following the hydrolysis of filter paper by EG5C and EG5C-1. Lane M â glucose unit markers, i.e. glucose (G1), cellobiose (G2), cellotriose (G3), cellotetraose (G4) and cellopentaose (G5). Table S1. Primers used for plasmid construction of EG5C, EG5C-1 and EG5C-2. Table S2. Primers used for the generation of site-directed mutants of EG5C-1. Table S3. Cellulose binding properties of EG5C-1 and its site-directed mutants.
FOLKLORE AND FANTASY ELEMENTS IN ENGLISH FANTASY FICTION: A COMPARATIVE ANALYSIS OF NEIL GAIMAN'S AMERICAN GODS AND J.R.R. TOLKIEN'S THE HOBBIT
Creators: name: Djurayeva, Sevinch
Publisher: name: Zenodo
Year: 2025

description: This study investigates the role of folklore and fantasy elements in English fiction, focusing on Neil Gaiman’s American Gods and J.R.R. Tolkien’s The Hobbit. By analyzing myths, legends, and cultural narratives, the paper explores how each author creates unique fantasy worlds while addressing themes of belief, identity, and cultural transformation. Tolkien reconstructs traditional myths into an immersive secondary world, while Gaiman reinterprets ancient deities in a modern setting. The research highlights folklore’s enduring adaptability and its essential contribution to the vitality of modern fantasy literature.
Facilitating profit-driven breeding for commercial cow-calf producers
Creators: name: Rowan, Troy
Publisher: name: American Association of Bovine Practitioners  Conference Proceedings
Year: 2022
Subjects: genetics
breeding
selection

description: Sire selection is one of the most critical decisions that a com­mercial beef cattle operation makes. Many producers look to their veterinarians for advice on genetic selection decisions. Developing a profit-aligned breeding goal is essential in setting up an operation for success. Breeding goals should consider marketing endpoints and opportunities for producers to reduce animal maintenance and development costs. Each producer is different, so breeding goals must be appropriate for the pro­ducer’s environment and management level. A wealth of selec­tion tools exist for producers to maximize genetic progress and reduce risk. Using expected progeny differences (EPDs) for se­lection allows producers to focus selection on an animal’s esti­mated genetic merit. This reduces risk and increases the rate of genetic progress. Breed associations report EPDs on dozens of economically-relevant traits. Selection indices have been devel­oped to weight trait predictions by their economic importance and simplify the selection process. Using an index well-aligned with the breeding goal allows producers to select for increased profitability using a single value. These selection tools, com­bined with effective phenotypic evaluation, can enhance the ability of producers to make an effective bull selection decision.
description: American Association of Bovine Practitioners Conference Proceedings, 2022 Recent Graduate Conference Proceedings
Additional file 1: of miR-3928v is induced by HBx via NF-ÎşB/EGR1 and contributes to hepatocellular carcinoma malignancy by down-regulating VDAC3
Creators: name: Zhang, Qiaoge
name: Song, Ge
name: Yao, Lili
name: Liu, Yankun
name: Liu, Min
name: Li, Shengping
name: Tang, Hua
Publisher: name: figshare
Year: 2018
Subjects: subject: Cell Biology
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Supplementary methods: Detailed experimental materials and methods. Figure S1. Plasmid transfection efficiency. Figure S2. VDAC3 promotes the apoptosis of HCC cells. Figure S3. HBV/HBx infection enhances the malignancy of HCC cells via miR-3928v. (DOCX 1489Â kb)
Additional file 1: Table S1. of Prevalence and molecular characterization of Strongyloides stercoralis, Giardia duodenalis, Cryptosporidium spp., and Blastocystis spp. isolates in school children in Cubal, Western Angola
Creators: name: Dacal, Elena
name: Saugar, José
name: de Lucio, Aida
name: Hernández-de-Mingo, Marta
name: Robinson, Elena
name: Köster, Pamela
name: Aznar-Ruiz-de-Alegría, María
name: Espasa, Mateu
name: Ninda, Arlette
name: Gandasegui, Javier
name: Sulleiro, Elena
name: Moreno, Milagros
name: Salvador, Fernando
name: Molina, Israel
name: Rodríguez, Esperanza
name: Carmena, David
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: Computational Biology

description: Oligonucleotides used for the molecular identification and/or characterization of Strongyloides stercoralis, Giardia duodenalis, Cryptosporidium spp. and Blastocystis spp. in this study. (DOCX 14 kb)
Anaplasmosis: Practical principles for the diagnosis, treatment and control of field cases and outbreaks
Creators: name: Coetzee, Johann
Publisher: name: American Association of Bovine Practitioners  Conference Proceedings
Year: 2022
Subjects: anaplasmosis
outbreaks
biosecurity
cELISA

description: Anaplasmosis, caused by the rickettsial hemoparasite Ana­plasma marginale (Am), is the most prevalent tick-transmitted disease of cattle worldwide and a major obstacle to profitable beef production in the continental United States. Anaplasmosis is readily transmitted through biological and mechanical vec­tors such as ticks and biting flies and iatrogenically through needles and equipment contaminated with infected blood. Clinical anaplasmosis, characterized by anemia, icterus and fever, is associated with significant production losses, abor­tions and mortalities in cattle. It is estimated that the introduc­tion of anaplasmosis into a previously naïve herd can result in a 3.6% reduction in calf crop, a 30% increase in cull rate and a 30% mortality rate in clinically infected adult cattle. Further­more, a study has shown that 16% of pregnant carrier cows will transmit anaplasmosis in utero producing persistently infected offspring. The existence of both horizontal and vertical ana­plasmosis transmission has important implications for disease control in endemic areas. In this presentation, we will use case studies to examine strategies to treat and control anaplasmosis in beef and dairy herds.
description: American Association of Bovine Practitioners Conference Proceedings, 2022 Recent Graduate Conference Proceedings
Additional file 2: Table S1. of miR-3928v is induced by HBx via NF-ÎşB/EGR1 and contributes to hepatocellular carcinoma malignancy by down-regulating VDAC3
Creators: name: Zhang, Qiaoge
name: Song, Ge
name: Yao, Lili
name: Liu, Yankun
name: Liu, Min
name: Li, Shengping
name: Tang, Hua
Publisher: name: figshare
Year: 2018
Subjects: subject: Molecular Biology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Sequences of primers used in this study. (DOCX 29Â kb)
Development of 3-D predictive ageing simulations of reinforced concrete port structures
Creators: name: Siamphukdee, Kanjana
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: The aim of this research is to formulate an advanced computer model for predicting the deterioration of marine reinforced concrete (RC) structures due to corrosion of steel reinforcement. This research is a part of the larger Linkage Project LP0883290 which is co-funded by the Australian Research Council (ARC), Geelong Port, Sydney Ports and AECOM Ltd. Chloride-induced corrosion of internal steel reinforcement is one of the major causes of concrete premature deterioration which incur significant ongoing costs to repair and replace the affected infrastructure. Despite increased research efforts worldwide to predict damage propagation over the years, knowledge gaps remain and existing models still cannot satisfactorily produce outputs which match with the damage observed in field marine structures that are located in corrosive seawater tidal, splash, and aerosol spray conditions. A 3-D Finite Element (FEM) computer model was developed to simulate damage propagation in RC structures resulting from reinforcement corrosion. It addresses the limitations of the existing models by incorporating algorithms for predicting dynamic (time-variant) corrosion rate and simulating non-uniform distribution of rust products around the reinforcement bar. The FEM was also programmed so that the environmental factor inputs can be varied along the 3rd dimension of the structure, thereby allowing the spatial variation of damage in 3-D to be simulated. The FEM can provide visual outputs for the development of corrosion-induced cracks over time and can be used to predict the type of damage and the time of damage occurrence within the concrete cover zone. The 3-D FEM was calibrated against published experimental data in the literature and against port data collected from field marine structures. It was found that the 3-D FEM damage predictions matched closely with the damage published in the literature and the damage observed in field structures. The 3-D FEM was used to analyse a wide range of corrosion scenarios involving different structural geometries, material properties and environmental exposures. The analysis results were used to formulate damage maps and regression models, which can be used by port asset managers who may not have the expertise to use the FEM to predict the damage propagation in RC structures. The key outcomes of this research have improved the understanding of concrete deterioration behaviour by providing new capabilities to predict the location, time of occurrence, type and degree of damage in field marine RC structures. This enhanced modelling allows port asset managers to make better decisions regarding the timing and method of repair and/or rehabilitation over the life cycle.
Institutional pathologies and urban water access: a case study of Jakarta, Indonesia
Creators: name: Prabaharyaka, Indrawan
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: In this dissertation, I offer institutional pathologies as a conceptual framework to analyse the seemingly intractable problems in water governance, and relate it to urban water access, using the case study of Jakarta. In this context, access to water refers to ease of accessibility to water sources in terms of quantity, quality, continuity and affordability. Institutional pathologies imply persistent institutional deviants and dysfunctional behaviours in water governance as shared by multiple actors. Specifically I develop three concepts of institutional pathologies: patrimonialism, confidentiality and informality. Patrimonialism refers to the pattern of bureaucracy that is heavily centred on central government and a central figure(s). Confidentiality denotes the style of bureaucracy that tends to maintain secrecy of public information in the name of national stability and security. Informality, refers to meta-rules that shape the habits of actors. To study the relationship between institutional pathologies and urban water access, I trace the development of Jakarta water governance from the public era of 1977-1997 to the private era of 1998-2014. Using qualitative methodology and under the influence of institutional ethnography as the fieldwork research paradigm, the fieldwork chielfy employed in-depth interviews and documentary analysis as data collection methods to investigate the ruling relations. It is suggested that rather than merely being sourced from internal bureaucratic culture of specific organisations, that is public or private, institutional pathologies are produced by the ruling relations between multiple actors. Therefore institutional pathologies can be useful as a conceptual framework that allows for an advanced and pragmatic analysis, beyond the narrow debate of privatisation. It is suggested as well that institutional pathologies can be used to analyse other southern cities, which may experience similar problems with Jakarta.
Fabricating place story: an experiential approach to imprinting identity in landscape and land-culture.
Creators: name: Dent, Faith Beverley
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: As a consequence of migration, family, cultural and landscape markers that map heritage and maintain narratives and representations of continuity are disrupted, and can result in fragmented identity, and the loss of a sense of place and belonging. This research explores whether in a post-colonial and post-modernist society displacement can be mitigated by the performance of place: imprinting landscape and learning land-culture in personal spaces/places and heritage sites. The point of stability and continuity in a post-colonial context it is proposed can be found in one’s relationship with the landscape/place. My interest is in an embodied experience of the places and landscapes of my heritage in an attempt to work with and through displacement and find an identity that will sustain my living in Australia. This thesis, therefore, intends to make a contribution to the understanding and knowledge of the interdisciplinary studies of migrancy, identity-formation and place-making in the field of Place Studies, with an interwoven arts-practice that expresses an emotional/embodied response to landscape/place experience. I have named the multi-method narrative/experiential, post-qualitative approach as an embodied-kinaesthetic methodology. The implications are that the methods employed have restorative and dynamic capacities as an everyday practice of landscape/place experience in finding belonging and identity as an ongoing practice. The themes that I negotiate focus on landscape/place as the arena where issues of migration, transition and transformation are played out. I explore my heritage as multi-layered: formative and forming of my identity in each of the locations from which my forebears hailed, in Europe, South Africa and Australia, to retrieve snapshots of recorded/archival history and fabricate a new place-story in an embodied performative experience of place-making and identity formation. As I recognise that the processes are contingent and always partial, my interest is in enunciating and testing an approach where the researcher is the researched. The pro-active methods employed include: embodied knowing, visual knowing, and textual/oral knowing and an interwoven arts-practice. My encounters with landscape/place are analysed through the fractal nature of place, with identity and belonging traced thematically in what I call: the Seven Marks of Place: landmarks, placemarks, pathmarks, stretchmarks, crossmarks, stitchmarks and bookmarks; and in the conclusion I discuss benchmarks: where I am up to in my research. Place-story is fabricated/fabric-ated – hyphenated to designate the processes of fabric art and embodied actions that leave an impression beyond the immediate event – with the dual meaning of fabrication: made up and made into, kept open and organic in its interpretation.