cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Speaker Identification in the Shouted Environment Using Suprasegmental Hidden Markov Models
Creators: name: Shahin, Ismail
Publisher: name: arXiv
Year: 2017
Subjects: subject: Sound (cs.SD)
subject: FOS: Computer and information sciences

description: In this paper, Suprasegmental Hidden Markov Models (SPHMMs) have been used to enhance the recognition performance of text-dependent speaker identification in the shouted environment. Our speech database consists of two databases: our collected database and the Speech Under Simulated and Actual Stress (SUSAS) database. Our results show that SPHMMs significantly enhance speaker identification performance compared to Second-Order Circular Hidden Markov Models (CHMM2s) in the shouted environment. Using our collected database, speaker identification performance in this environment is 68% and 75% based on CHMM2s and SPHMMs respectively. Using the SUSAS database, speaker identification performance in the same environment is 71% and 79% based on CHMM2s and SPHMMs respectively.
Analysis and forecast on changes in the level of harmful substance emissions from aviation gas turbine engines.
Creators: name: S. Dmytriyev
name: V. Loginov
name: V. Gusev
name: T. Stepanova
Publisher: name: Zenodo
Year: 2019

description: The projected levels of NOх emissions for the standard LTO cycle were shown. The estimated range of applying the advanced schemes of fuel combustion in terms of engine OPR was reviewed based on of research results in world experience. Based on the Ivchenko-Progress SE experience in design of combustion chambers the forecasting of the NOх level emitted from air engines was made. The estimated rates of NOx emission level reduction were determined and shown for the period till 2050 engines depending on engine thrust class. The probability of achieving the aims of Flightpath 2050, Challenge 3, Goal 1, was shown for engines with different thrust range.
Characterization of methane emissions from five cold heavy oil production with sands (CHOPS) facilities
Creators: name: Roscioli, Joseph R.
name: Herndon, Scott C.
name: Yacovitch, Tara I.
name: W. Berk Knighton
name: Zavala-Araiza, Daniel
name: Johnson, Matthew R.
name: Tyner, David R.
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Inorganic Chemistry
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Cold heavy oil production with sands (CHOPS) is a common oil extraction method in the Canadian provinces of Alberta and Saskatchewan that can result in significant methane emissions due to annular venting. Little is known about the magnitude of these emissions, nor their contributions to the regional methane budget. Here the authors present the results of field measurements of methane emissions from CHOPS wells and compare them with self-reported venting rates. The tracer ratio method was used not only to analyze total site emissions but at one site it was also used to locate primary emission sources and quantify their contributions to the facility-wide emission rate, revealing the annular vent to be a dominant source. Emissions measured from five different CHOPS sites in Alberta showed large discrepancies between the measured and reported rates, with emissions being mainly underreported. These methane emission rates are placed in the context of current reporting procedures and the role that gas-oil ratio (GOR) measurements play in vented volume estimates. In addition to methane, emissions of higher hydrocarbons were also measured; a chemical “fingerprint” associated with CHOPS wells in this region reveals very low emission ratios of ethane, propane, and aromatics versus methane. The results of this study may inform future studies of CHOPS sites and aid in developing policy to mitigate regional methane emissions. Implications: Methane measurements from cold heavy oil production with sand (CHOPS) sites identify annular venting to be a potentially major source of emissions at these facilities. The measured emission rates are generally larger than reported by operators, with uncertainty in the gas-oil ratio (GOR) possibly playing a large role in this discrepancy. These results have potential policy implications for reducing methane emissions in Alberta in order to achieve the Canadian government’s goal of reducing methane emissions by 40–45% below 2012 levels within 8 yr.
Cosmological imprints of string axions in plateau
Creators: name: Soda, Jiro
name: Urakawa, Yuko
Publisher: name: arXiv
Year: 2017
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We initiate a study on various cosmological imprints of string axions whose scalar potentials have plateau regions. In such cases, we show that a delayed onset of oscillation generically leads to a parametric resonance instability. In particular, for ultralight axions, the parametric resonance can enhance the power spectrum slightly below the Jeans scale, alleviating the tension with the Lyman $α$ forest observations. We also argue that a long-lasting resonance can lead to an emission of gravitational waves at the frequency bands which are detectable by gravitational wave interferometers and pulsar timing arrays.
description: 5 pages, 5 figures; v2: references added, v3: matches with the published version
Oscillons from String Moduli
Creators: name: Antusch, Stefan
name: Cefala, Francesco
name: Krippendorf, Sven
name: Muia, Francesco
name: Orani, Stefano
name: Quevedo, Fernando
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: A generic feature of string compactifications is the presence of many scalar fields, called moduli. Moduli are usually displaced from their post-inflationary minimum during inflation. Their relaxation to the minimum could lead to the production of oscillons: localised, long-lived, non-linear excitations of the scalar fields. Here we discuss under which conditions oscillons can be produced in string cosmology and illustrate their production and potential phenomenology with two explicit examples: the case of an initially displaced volume modulus in the KKLT scenario and the case of a displaced blow-up Kaehler modulus in the Large Volume Scenario (LVS). One, in principle, observable consequence of oscillon dynamics is the production of gravitational waves which, contrary to those produced from preheating after high scale inflation, could have lower frequencies, closer to the currently observable range. We also show that, for the considered parameter ranges, oscillating fibre and volume moduli do not develop any significant non-perturbative dynamics. Furthermore, we find that the vacua in the LVS and the KKLT scenario are stable against local overshootings of the field into the decompatification region, which provides an additional check on the longevity of these metastable configurations.
description: 32 pages + appendix, 23 figures, for videos of the simulations see https://particlesandcosmology.unibas.ch/downloads/oscillons-from-string-moduli-movies.html
MOESM7 of Comprehensive bioinformatics analysis of acquired progesterone resistance in endometrial cancer cell line
Creators: name: Li, Wenzhi
name: Wang, Shufen
name: Qiu, Chunping
name: Liu, Zhiming
name: Zhou, Qing
name: Kong, Deshui
name: Ma, Xiaohong
name: Jiang, Jie
Publisher: name: figshare
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology

description: Additional file 7: Figure S1. The survival curves of 7 PGR co-expressed genes comparing the patients with high (red) and low (black) expression in endometrial cancer.
Substantiation of economic efficiency of using a solar dryer under conditions of personal peasant farms
Creators: name: M. Babych
name: S. Korobka
name: Skrynkovskyy, Ruslan
name: S.Korobka
name: R. Krygul
Publisher: name: figshare
Year: 2018
Subjects: subject: 140201 Agricultural Economics
subject: FOS: Economics and business
subject: 109999 Technology not elsewhere classified
subject: FOS: Other engineering and technologies

description: Babych, M., Korobka, S., Skrynkovskyy, R., Korobka, S., & Krygul, R. (2016). Substantiation of economic efficiency of using a solar dryer under conditions of personal peasant farms. Eastern-European Journal Of Enterprise Technologies, 6(8 (84)), 41-47.
Search for direct production of supersymmetric partners of the top quark in the all-jets final state in proton-proton collisions at sqrt(s) = 13 TeV
Creators: name: CMS Collaboration
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: A search for direct production of top squark pairs in events with jets and large transverse momentum imbalance is presented. The data are based on proton-proton collisions at a center-of-mass energy of 13 TeV, collected in 2016 at the CERN LHC, and correspond to an integrated luminosity of 35.9 inverse femtobarns. The search considers a variety of R-parity conserving supersymmetric models, including ones for which the top squark and neutralino masses are nearly degenerate. Specialized jet reconstruction tools are developed to exploit the unique characteristics of the signal topologies. With no significant excess of events observed above the standard model expectations, upper limits are set on the direct top squark pair production cross section in the context of simplified supersymmetric models for various decay hypotheses. Models with larger differences in mass between the top squark and neutralino are probed for masses up to 1040 and 500 GeV, respectively, whereas models with a more compressed mass hierarchy are probed up to 660 and 610 GeV, respectively. The smallest mass difference probed is for masses near to 550 and 540 GeV, respectively.
description: Replaced with the published version. Added the journal reference and DOI. All the figures and tables, including additional supplemental figures and tables, can be found at http://cms-results.web.cern.ch/cms-results/public-results/publications/SUS-16-049 (CMS Public Pages)
SensApp_Deliverable_D1.4_First plan for dissemination and exploitation
Creators: name: Vespini, Veronica
Publisher: name: Zenodo
Year: 2020
Subjects: Dissemination , Exploitation Plan

description: The deliverable D1.4 “First plan for dissemination and exploitation” describes the activities to be performed and the channels to be used to promote and disseminate the project and its outputs, and to exploit the project results. The communication strategy and methodology
 were planned at the very beginning of the project within the consortium to obtain the best and largest impact on the European Community and to increase the visibility of the project. The initial set of communication tools (described in deliverable D1.1) is continuously updated and integrated during the whole project life.
Copolymer Micelle-administered Melatonin Ameliorates Hyperosmolarity-induced Ocular Surface Damage through Regulating PINK1-mediated Mitophagy
Creators: name: Xu, Jing
name: Chen, Peng
name: Zhao, Guangfen
name: Wei, Susu
name: Li, Qiqi
name: Guo, Chuanlong
name: Cao, Qilong
name: Wu, Xianggen
name: Di, Guohu
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Computational Biology

description: To investigate the role and mechanism of melatonin-loaded polymer polyvinyl caprolactam–polyvinyl acetate–polyethyleneglycol graft copolymer micelles (Mel-Mic) in dry eye disease (DED). In vitro, the apoptosis and reactive oxygen species (ROS) generation in human corneal epithelial cells (HCECs) were analyzed by immunostaining and flow cytometry. The effect of Mel-Mic on autophagy and mitophagy was evaluated by immunostaining and western blots. PINK1 knockdown was analyzed by small interfering RNA. In vivo, sodium fluorescein staining, tear secretion test, and periodic acid-Schiff staining were used to determine whether Mel-Mic can alleviate the severity of DED. Small molecule antagonists were pretreated to investigate whether melatonin type 1 and/or 2 receptors (MT1/MT2) mediate the effects of Mel-Mic. Mel-Mic improved the solubility and biological activities of Mel in aqueous solutions. Treatment with Mel-Mic decreased the apoptosis of HCECs exposed to hyperosmotic medium, accompanied by downregulation of cleaved Caspase-3 and upregulation of Bcl-2. In addition, Mel-Mic application suppressed ROS overproduction, rescued mitochondrial function, and decreased the level of oxidative stress associated biomarkers (COX-2 and 4-HNE) in HCECs. Interestingly, HCECs treated with Mel-Mic exhibited increased levels of mitophagy markers (PINK1, PARKIN, Beclin 1, and LC3B) and restored impaired mitophagic flux under hyperosmolarity. While PINK1 knockdown largely abolished its protective effects. In vivo, compared to vehicle group, topical Mel-Mic-solution-treated mice showed significantly improved clinical parameters, increased tear production, and decreased goblet cells loss in a dose-dependent manner. Also, transmission electron microscopic assay revealed increased autophagosome number in the corneal epithelium of Mel-Mic group. Moreover, luzindole, a nonselective MT1/MT2 antagonist, but not 4-P-PDOT, a selective MT2 antagonist, blocked the protective effect of Mel-Mic. Our findings demonstrated that Mel-Mic ameliorates hyperosmolarity-induced ocular surface damage via PINK1-mediated mitophagy and may represent an effective treatment for DED possibly through acting MT1 receptor.
Branching rules related to spherical actions on flag varieties
Creators: name: Avdeev, Roman
name: Petukhov, Alexey
Publisher: name: arXiv
Year: 2017
Subjects: subject: Representation Theory (math.RT)
subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 20G05, 22E46, 14M15, 14M27

description: Let $G$ be a connected semisimple algebraic group and let $H \subset G$ be a connected reductive subgroup. Given a flag variety $X$ of $G$, a result of Vinberg and Kimelfeld asserts that $H$ acts spherically on $X$ if and only if for every irreducible representation $R$ of $G$ realized in the space of sections of a homogeneous line bundle on $X$ the restriction of $R$ to $H$ is multiplicity free. In this case, the information on restrictions to $H$ of all such irreducible representations of $G$ is encoded in a monoid, which we call the restricted branching monoid. In this paper, we review the cases of spherical actions on flag varieties of simple groups for which the restricted branching monoids are known (this includes the case where $H$ is a Levi subgroup of $G$) and compute the restricted branching monoids for all spherical actions on flag varieties that correspond to triples $(G,H,X)$ satisfying one of the following two conditions: (1) $G$ is simple and $H$ is a symmetric subgroup of $G$; (2) $G = \mathrm{SL}_n$.
description: v3: 39 pages, some corrections in the list of references
Color screening in flux tubes and in the color Coulomb potential from the QCD Field Correlators
Creators: name: Lukashov, M. S.
name: Simonov, Yu. A.
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: Colorelectric and Colormagnetic structure of the flux tubes, connecting heavy quark and antiquark, is investigated in the framework of the Field Correlator method which describes all resulting fields in terms of correlators $D^E$ and $D^E_1$. The latter have been computed via gluelumps, which allows to predict the resulting distribution of color fields $\mathbf{E} (\mathbf{r}),$ and colormagnetic currents $\mathbf{k} (\mathbf{r})$ in the flux tubes. It is shown, that at large distances $r\gg λ\approx 0.2$ fm the whole structure of fields and relations between them is similar to that of the dual superconductor theory, but the basic dynamics, including small distances, is given by field correlators of the real stochastic vacuum. The important contradiction between the strong screening of color fields in the width of flux tubes and almost no screening in the perturbative $Q\bar Q$ potential is resolved.
description: 1+15 pages, 10 figures
Supplementary document for Airy-Talbot plasmon: an accelerating self-imaging surface wave - 5734035.pdf
Creators: name: Tu, Zhifeng
name: Wu, You
name: hu, hongcheng
name: Zhao, Jiajia
name: Tang, Huilin
name: Chen, Yanru
name: Yang, Haobin
name: xu, chuangjie
name: Deng, Dongmei
Publisher: name: Optica Publishing Group
Year: 2022
Subjects: Uncategorized

description: Supplemental document for the formula derivation and the initial input
Green waste compost as a substitute for turfy soil in external-soil spray seeding substrate
Creators: name: Luo, Chao
name: Guo, Xiaoping
name: Liu, Guanhong
name: Zhao, Tingning
name: Wang, Yingyu
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Computational Biology

description: The scarcity of turfy soil (TS), which is the most commonly used external-soil spray seeding (ESSS) substrate component, has recently increased. The aim of this study was to introduce a substitute for TS as an organic matter additive in substrate. Green waste compost (GWC) that was combined with sandy loam soil, polyacrylamide (PAM), and super absorbent polymer (SAP) was used for preparing the soil substrate. Further, a modified soil-spraying experiment and artificial rainfall experiments with an orthogonal design (L1643) were conducted. These experiments assessed the feasibility of GWC as a component of ESSS substrate and the optimal formulation. The results indicated that the degree of influence of the three factors controlling the amended substrate is GWC > PAM > SAP. GWC improved the physical and chemical properties of the substrate, as well as the seed germination rate and seedling growth. Significant improvements can be observed with respect to the soil bulk density, soil porosity, steady infiltration rate, and anti-shearing strength (p < .01). Additionally, the runoff and soil loss decreased under heavy rainfall. Except for the soil nutrients and seedling height, all other indicators of the GWC substrates were better than those of the commercially available TS substrates. Principal component analysis and range analysis revealed that the optimum values of various design parameters were 40% for the compost volume content, 200 g m−3 for PAM and 100 g m−3 for SAP. Based on these results, GWC can be considered to be an effective alternative to TS for ESSS.
title: ADCO, Cartulaire de l'abbaye de Saint-Seine (XIIIe siècle), Cart. 165 (10 H 6, ms. 139), 354 pages, f. 0002
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2009
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire de l'abbaye de Saint-Seine (XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 165 (10 H 6, ms. 139), 354 pages, f. 0002, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de l'abbaye de Saint-Seine (XIIIe siècle), Archives départementales de la Côte-d'Or, Cart. 165 (10 H 6, ms. 139), 354 pages, f. 0002, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Saint-Seine
description: Provenance: http://www.wikidata.org/entity/Q2820709
Toward Community Software Ecosystems for High-Performance Computational Science
Creators: name: McInnes, Lois Curfman
Publisher: name: figshare
Year: 2018
Subjects: subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Computer Software
subject: FOS: Computer and information sciences
subject: 80204 Mathematical Software
subject: 80306 Open Software

description: Software—crosscutting technology that connects advances in mathematics, computer science, and domain-specific science and engineering—is a cornerstone of long-term collaboration and scientific progress. As we leverage unprecedented high-performance computing resources to work toward predictive science, software complexity is increasing due to multiphysics and multiscale modeling, the coupling of simulations and data analytics, and the demand for greater reproducibility in the midst of disruptive architectural changes. Applications increasingly require the combined use of independent software packages, which have diverse sponsors, priorities, and processes for development and release. These challenges create the unique opportunity to fundamentally change how scientific software is designed, developed, and sustained---with explicit work toward scientific software ecosystems. This presentation will introduce the xSDK, or Extreme-scale Scientific Software Development Kit, where community-defined policies are increasing the quality and interoperability across numerical libraries as needed by the DOE Exascale Computing Project. We will also discuss complementary efforts to increase scientific software productivity and sustainability.
Capacity of entanglement and distribution of density matrix eigenvalues in gapless systems
Creators: name: Nakagawa, Yuya O.
name: Furukawa, Shunsuke
Publisher: name: arXiv
Year: 2017
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We propose that the properties of the capacity of entanglement (COE) in gapless systems can efficiently be investigated through the use of the distribution of eigenvalues of the reduced density matrix (RDM). The COE is defined as the fictitious heat capacity calculated from the entanglement spectrum. Its dependence on the fictitious temperature can reflect the low-temperature behavior of the physical heat capacity, and thus provide a useful probe of gapless bulk or edge excitations of the system. Assuming a power-law scaling of the COE with an exponent $α$ at low fictitious temperatures, we derive an analytical formula for the distribution function of the RDM eigenvalues. We numerically test the effectiveness of the formula in relativistic free scalar boson in two spatial dimensions, and find that the distribution function can detect the expected $α=3$ scaling of the COE much more efficiently than the raw data of the COE. We also calculate the distribution function in the ground state of the half-filled Landau level with short-range interactions, and find a better agreement with the $α=2/3$ formula than with the $α=1$ one, which indicates a non-Fermi-liquid nature of the system.
description: 9 pages, 4 figures
Distribution Characteristics of Anammox Bacteria in Ancient Canal (Guyun River) Riparian Sediment of Zhenjiang, China
Creators: name: Zhou, Xiaohong
name: Li, Yimin
name: Wen, Chunzi
name: Liu, Dan
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Riparian sediment is an important active interface zone for nitrogen-biogeochemical cycles. However, the distribution characteristics of anammox bacteria are not adequately described in the riparian sediment of urban rivers. Therefore, the distribution characteristics of anammox bacteria of Guyun river riparian sediment, which is the representative urban river, were investigated in this study. Research results showed that anammox bacterial abundance showed a significant spatial variation at the study area. Abundance values ranged from 2.00 × 105 to 1.92 × 107 copies·g−1 dry sediment. And the average value was 6.64×106 copies·g−1 dry sediment in six collected samples. Abundance of anammox bacteria was significantly related to TN, NH4+-N, and pH. Slight spatial variations of richness and diversity in Guyun river riparian sediment were obtained and physicochemical parameters of sediment samples did not significantly influence the biodiversity index of anammox bacteria. Phylogenetic analysis indicated that all amplified sequences fell within the known anammox bacterial group, i.e., Brocadia, Anammoxoglobus/Jettenia, and Kuenenia, with proportions of 33.91%, 24.35%, and 41.74%, respectively. The relative abundance of anammox bacteria showed distinctive spatial heterogeneity in six different sample sites. This finding indicated a distinct spatial variation of anammox bacterial in Guyun river riparian sediment.
chemistry, IC50 curves, added biology from Pyrazole-based inhibitors of enhancer of zeste homologue 2 induce apoptosis and autophagy in cancer cells
Creators: name: Mellini, Paolo
name: Marrocco, Biagina
name: Borovika, Diana
name: Polletta, Lucia
name: Carnevale, Ilaria
name: Saladini, Serena
name: Stazi, Giulia
name: Zwergel, Clemens
name: Peteris Trapencieris
name: Ferretti, Elisabetta
name: Tafani, Marco
name: Valente, Sergio
name: Mai, Antonello
Publisher: name: The Royal Society
Year: 2018
Subjects: Biochemistry
Cell Biology
Molecular Biology

description: Novel pyrazole-based EZH2 inhibitors have been prepared through a molecular pruning approach from known inhibitors bearing a bicyclic moiety as a central scaffold. The hit compound 1o [N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-methyl-1-phenyl-1H-pyrazole-4-carboxamide] showed low micromolar EZH2/PRC2 inhibition and high selectivity towards a panel of other methyltransferases. Moreover, 1o displayed cell growth arrest in breast MDA-MB231, leukaemia K562, and neuroblastoma SK-N-BE cancer cells joined to reduction of H3K27me3 levels and induction of apoptosis and autophagy.This article is part of a discussion meeting issue ‘Frontiers in epigenetic chemical biology’.
Non-Reciprocal gain in non-Hermitian time-Floquet Systems
Creators: name: Koutserimpas, Theodoros T.
name: Fleury, Romain
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We explore the unconventional wave scattering properties of non-Hermitian systems in which amplification or damping are induced by time-periodic modulation. These non- Hermitian time-Floquet systems are capable of non-reciprocal operations in the frequency domain, which can be exploited to induce novel physical phenomena such as unidirectional wave amplification and perfect non-reciprocal response with zero or even negative insertion losses. This unique behavior is obtained by imparting a specific low-frequency time-periodic modulation to the coupling between lossless resonators, promoting only upward frequency conversion, and leading to non-reciprocal parametric gain. We provide a full-wave demonstration of our findings in a one-way microwave amplifier, and establish the potential of non-Hermitian time-Floquet devices for insertion-loss free microwave isolation and unidirectional parametric amplification.
description: 15 pages, 4 figures
The distribution of tilt angles in newly born NSs: role of interior viscosity and magnetic field
Creators: name: Dall'Osso, Simone
name: Perna, Rosalba
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We study how the viscosity of neutron star (NS) matter affects the distribution of tilt angles ($χ$) between the spin and magnetic axes in young pulsars. Under the hypothesis that the NS shape is determined by the magnetically-induced deformation, and that the toroidal component of the internal magnetic field exceeds the poloidal one, we show that the dissipation of precessional motions by bulk viscosity can naturally produce a bi-modal distribution of tilt angles, as observed in radio/$γ$-ray pulsars, with a low probability of achieving $χ\sim (20^\circ - 70^\circ)$ if the interior B-field is $\sim (10^{11} - 10^{15})$~G and the birth spin period is $\sim 10 - 300$~ms. As a corollary of the model, the idea that the NS shape is solely determined by the poloidal magnetic field, or by the centrifugal deformation of the crust, is found to be inconsistent with the tilt angle distribution in young pulsars. When applied to the Crab pulsar, with $χ\sim 45^\circ - 70^\circ$ and birth spin $\sim$ 20 ms, our model implies that: (i) the magnetically-induced ellipticity is $ε_B \gtrsim 3 \times 10^{-6}$; (ii) the measured positive $\dotχ \sim 3.6 \times 10^{-12}$ rad s$^{-1}$ requires an additional viscous process, acting on a timescale $\lesssim 10^4$ yrs. We interpret the latter as crust-core coupling via mutual friction in the superfluid NS interior. One critical implication of our model is a GW signal at (twice) the spin frequency of the NS, due to $ε_B \sim 10^{-6}$. This could be detectable by Advanced LIGO/Virgo operating at design sensitivity.
description: 12 pages, 3 figures, accepted for publication in M.N.R.A.S
Supplementary document for VoxDMRN: A voxelwise Deep Max-Pooling residual network for Bioluminescence tomography Reconstruction - 5730042.pdf
Creators: name: Li, ShuangChen
name: Yu, Jingjing
name: He, Xuelei
name: hongbo, Guo
name: He, Xiaowei
Publisher: name: Optica Publishing Group
Year: 2022
Subjects: Uncategorized

description: Supplemental Document
G. Du Plessis, An Integral Ontology of Addiction: A multiple object existing as a continuum of ontological complexity Journal of Integral Theory and Practice, 9(1), 2014.pdf
Creators: name: Plessis, Guy Du
Publisher: name: figshare
Year: 2018
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences

description: Inn previous work I explored how Integral Theory can be applied as a metatheoretical and transdisciplinary framework, in an attempt to arrive at an integrally informed metatheory of addiction. There was an overemphasis on Integral Methodological Pluralism in that thread of research, without clarifying the ontological pluralism of addiction as a multiple object enacted by various methodologies. To arrive at a comprehensive integral metatheory and integral ontology of addiction, I believe it is necessary to include the conception of Integral Pluralism and Integral Enactment Theory as posited by Sean Esbjörn-Hargens. Integral Enactment Theory highlights the phenomenon of addiction as a multiple and dynamic object arising along a continuum of ontological complexity; it adeptly points out how etiological models “co-arise” in relation to methodology (methodological pluralism) to enact a particular reality of addiction (ontological pluralism) while being mediated by the worldview of the subject (epistemological pluralism) applying the method. This article briefly explores the significance of including Integral Pluralism and Integral Enactment Theory in the quest of an integral metatheory and integral ontology of addiction.
Walter Sid Lee
Creators: name: Project Team, Their Finest Hour
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: My father, Walter Sid Lee, was born in Northants about 1923; he tried to join RAF, but served in the TA and was called up in Rusden, Northants.He served in the Royal Engineers in AT6 (Anti-tank Regiment). He became the owner of a Valentine Tank. Short spell in a Sherman tank, American. Rose to the rank of Major, Acting Lt Col.His troop were pinned down in a wood and brought down a Fokker aircraft, probably in France, with a Browning machine gun and was awarded an Oak Leaf cluster as Mentioned in Dispatches.There is a recording of him being interviewed by a lady from Bovington Tank Museum, Nancy Langmaid. It was held by the museum.He was a devout British Legion supporter.
Sub-radian-accuracy gravitational waveforms of coalescing binary neutron stars in numerical relativity
Creators: name: Kiuchi, Kenta
name: Kawaguchi, Kyohei
name: Kyutoku, Koutarou
name: Sekiguchi, Yuichiro
name: Shibata, Masaru
name: Taniguchi, Keisuke
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Extending our previous studies, we perform high-resolution simulations of inspiraling binary neutron stars in numerical relativity. We thoroughly carry through a convergence study in our currently available computational resources with the smallest grid spacing of $\approx 63$--86~meter for the neutron-star radius 10.9--13.7\,km. The estimated total error in the gravitational-wave phase is of order 0.1~rad for the total phase of $\gtrsim 210$\,rad in the last $\sim 15$--16 inspiral orbits. We then compare the waveforms (without resolution extrapolation) with those calculated by the latest effective-one-body formalism (tidal SEOBv2 model referred to as TEOB model). We find that for any of our models of binary neutron stars, the waveforms calculated by the TEOB formalism agree with the numerical-relativity waveforms up to $\approx 3$\,ms before the peak of the gravitational-wave amplitude is reached: For this late inspiral stage, the total phase error is $\lesssim 0.1$\,rad. Although the gravitational waveforms have an inspiral-type feature for the last $\sim 3$\,ms, this stage cannot be well reproduced by the current TEOB formalism, in particular, for neutron stars with large tidal deformability (i.e., lager radius). The reason for this is described.
description: 13 pages, 11 figures, submitted to PRD
Revisiting Quasiparticle Scattering Interference in High-Temperature Superconductors: The Problem of Narrow Peaks
Creators: name: Sulangi, Miguel Antonio
name: Allan, Milan P.
name: Zaanen, Jan
Publisher: name: arXiv
Year: 2017
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: We revisit the interpretation of quasiparticle scattering interference in cuprate high-$T_c$ superconductors. This phenomenon has been very successful in reconstructing the dispersions of d-wave Bogoliubov excitations, but the successful identification and interpretation of QPI in scanning tunneling spectroscopy (STS) experiments rely on theoretical results obtained for the case of isolated impurities. We introduce a highly flexible technique to simulate STS measurements by computing the local density of states using real-space Green's functions defined on two-dimensional lattices with as many as 100,000 sites. We focus on the following question: to what extent can the experimental results be reproduced when various forms of distributed disorder are present? We consider randomly distributed point-like impurities, smooth "Coulombic" disorder, and disorder arising from random on-site energies and superconducting gaps. We find an apparent paradox: the QPI peaks in the Fourier-transformed local density of states appear to be sharper and better defined in experiment than those seen in our simulations. We arrive at a no-go result for smooth-potential disorder since this does not reproduce the QPI peaks associated with large-momentum scattering. An ensemble of point-like impurities gets closest to experiment, but this goes hand in hand with impurity cores that are not seen in experiment. We also study the effects of possible measurement artifacts (the "fork mechanism"), which turn out to be of relatively minor consequence. It appears that there is an unknown mechanism at work which renders the QPI peaks much sharper than they are based on present theoretical understanding.
description: 23 pages, 25 figures, published version, includes minor changes
‘Learner-centredness’ in English language education in Thai universities: A narrative-based inquiry into EFL teachers’ beliefs, practices and identities
Creators: name: AUNYARAT TANDAMRONG
Publisher: name: Monash University
Year: 2018
Subjects: Education

description: This PhD is a narrative-based case study, investigating the knowledge and practices of 11 English as a Foreign Language (EFL) teachers in four universities across Thailand with respect to the nationally mandated policy of ‘learner-centred education’ (LCE). Data was generated through semi-structured interviews and classroom observations, and analysed using a combination of thematic and narrative inquiry methods. The study finds large variations in the teachers’ knowledge, classroom practices, professional development experiences and professional identities. It urges policy-makers to re-visit LCE policy, considering the feasibility of its implementation. It also encourages institutional leaders to better support teachers’ ongoing professional learning needs.
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Cart. 188 (11 H 73), f. 0047r
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Archives départementales de la Côte-d'Or, Cart. 188 (11 H 73), f. 0047r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Archives départementales de la Côte-d'Or, Cart. 188 (11 H 73), f. 0047r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
داستان برند شرکت مینو
Creators: name: Bahman Maleki
Publisher: name: Zenodo
Year: 2025

description: «مینو» شاید آشناترین نام در صنعت شکلات و بیسکویت باشد که چند نسل با آن خاطرات خوشی داشته‌اند. 

شرکت سهامی خاص خوراک ایران در سال 1338 هجری شمسی ایران توسط خانواده خسروشاهی بنیان نهاده شد علی خسروشاهی اولین مدیر این شرکت بود و در ۱۶ آبان همان سال فعالیت تولیدی خود را با تأسیس شرکت صنعتی پارس مینو آغاز کرد.

خسروشاهی در پاییز 1338 با جلب رضایت شرکت هنکل آلمان، نمایندگی توزیع «تاید» را گرفت و انحصار بازار پودر رخت‌شویی ایران را از آن خود کرد. 

 

شمار کارگرهای کارخانه شرکت "پارس مینو" در ابتدا بیشتر از ۱۵ نفر نبود و این کارخانه، تولید مواد غذایی را با تولید آب‌نبات و تافی شروع کرد. همزمان، شرکت مینو به دنبال راه اندازی قسمت داروسازی نیز بود و قرار شد داروهای بوتس را در ایران تحت لیسانس بسازند. خسروشاهی توانست توجه و موافقت شرکت بوتس را برای گرفتن لیسانس این شرکت به گروه صنعتی مینو جلب کند.«تافی» اولین محصول مینو بود که با نام «تافی کره ای سه ستاره» تولید شد که به همراه کاکا جز اولین تافی های صنعتی ایران بودند.تافی سه ستاره با همان ظاهر و سیمای همیشگی همچنان تولید می‌شود و هم اینک نیز سهم تعیین کننده در بازار تافی ایران دارد. 

بعد از رواج گرفتن تافی‌های مینو در بازار ایران، محصولی با فرمولاسیون آلمان شرقی به نام آبنبات شیری توسط مینو به بازار عرضه شد که بسیار زود باعث افزایش اعتبار این شرکت در بین مردم ایران شد. این محصول آبنبات شیری مینو نام داشت. آبنبات‌هایی سه گوش که ابتدا به صورت فله ای و کیلویی تولید و در بازار عرضه می‌شد و به مرور زمان با بسته بندی اختصاصی و نشان مینو وارد بازار شد. این محصول خیلی زود مورد پسند مصرف کنندگان قرار گرفت و فروش بسیار خوبی پیدا کرد اما این محصول یک ایراد عمده داشت و آن هم این بود که رقبای شرکت مینو توانستند محصول مشابهی را به‌دلیل فروش فله ای به بازار عرضه کنند. با وجود اینکه آب نبات شیری با نام مینو معروف بود اما چون دانه ای فروخته می‌شد و بسته بندی نداشت، برای مصرف کننده تفاوتی با سایر محصولات مشابه نداشت. روی قالب آب نبات شیری مینو در آن زمان فقط یک حرفk  بود. رقبا وقتی ماشین آلات ساخت را سفارش می‌دادند، این علامت را نیز حک می‌کردند علامت K شروع (اول اسم خسرو شاهی به انگلیسی) است. مدیران شرکت مینو با تغییر تاکتیک ، این محصول را با بسته بندی و نشان مینو به بازار عرضه کردند و به یکی از محصولات مطرح این مجموعه صنعتی تبدیل شد.

دهه ۱۳۴۰ دهه طلایی شرکت صنعتی مینو بود طوری که این شرکت با توسعه کارگاه‌ها، زمین‌های جدیدی خریداری کرد و کارخانجات مینو با سیاست عدم تمرکز صنایع در تهران در دهه‌های ۴۰ و ۵۰ شمسی، زمین مناسبی با وسعت کافی در خرمدره از توابع شهرستان زنجان خریداری کرد.
On Breast Cancer Detection: An Application of Machine Learning Algorithms on the Wisconsin Diagnostic Dataset
Creators: name: Agarap, Abien Fred
Publisher: name: arXiv
Year: 2017
Subjects: subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: This paper presents a comparison of six machine learning (ML) algorithms: GRU-SVM (Agarap, 2017), Linear Regression, Multilayer Perceptron (MLP), Nearest Neighbor (NN) search, Softmax Regression, and Support Vector Machine (SVM) on the Wisconsin Diagnostic Breast Cancer (WDBC) dataset (Wolberg, Street, & Mangasarian, 1992) by measuring their classification test accuracy and their sensitivity and specificity values. The said dataset consists of features which were computed from digitized images of FNA tests on a breast mass (Wolberg, Street, & Mangasarian, 1992). For the implementation of the ML algorithms, the dataset was partitioned in the following fashion: 70% for training phase, and 30% for the testing phase. The hyper-parameters used for all the classifiers were manually assigned. Results show that all the presented ML algorithms performed well (all exceeded 90% test accuracy) on the classification task. The MLP algorithm stands out among the implemented algorithms with a test accuracy of ~99.04%.
description: 5 pages, 5 figures, 2 tables, presented at the International Conference on Machine Learning and Soft Computing (ICMLSC) 2018 in Phu Quoc Island, Viet Nam
Determining the Nature of Late Gunn-Peterson Troughs with Galaxy Surveys
Creators: name: Davies, Frederick B.
name: Becker, George D.
name: Furlanetto, Steven R.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Recent observations have discovered long (up to ~110 Mpc/h), opaque Gunn-Peterson troughs in the z ~ 5.5 Lyman-alpha forest, which are challenging to explain with conventional models of the post-reionization intergalactic medium. Here we demonstrate that observations of the galaxy populations in the vicinity of the deepest troughs can distinguish two competing models for these features: deep voids where the ionizing background is weak due to fluctuations in the mean free path of ionizing photons would show a deficit of galaxies, while residual temperature variations from extended, inhomogeneous reionization would show an overdensity of galaxies. We use large (~550 Mpc/h) semi-numerical simulations of these competing explanations to predict the galaxy populations in the largest of the known troughs at z ~ 5.7. We quantify the strong correlation of Lyman-alpha effective optical depth and galaxy surface density in both models and estimate the degree to which realistic surveys can measure such a correlation. While a spectroscopic galaxy survey is ideal, we also show that a relatively inexpensive narrowband survey of Lyman-alpha-emitting galaxies is ~90% likely to distinguish between the competing models.
description: 12 pages, 16 figures. Submitted to ApJ
Additional file 1 of Calculating the dose of cisplatin that is actually utilized in hyperthermic intraperitoneal chemotherapy among ovarian cancer patients
Creators: name: Wang, Wu-yun
name: Wu, Miao-fang
name: Wu, Dong-bing
name: Wang, Li-juan
name: Li, Hui
name: Lin, Zhong-qiu
name: Li, Jing
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Marine Biology
subject: Cancer
subject: Mental Health

description: Additional file 1. Adverse events.