cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Χρήση της μεθόδου HPLC-DAD για την μέτρηση των οργανικών οξέων σε οίνους
title: Use of the HPLC-DAD for the measurements of organic acids in wines
titleType: AlternativeTitle
Creators: name: Φίλιππα, Αντιγόνη-Σοφία
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2024
Subjects: HPLC-DAD
Οργανικά οξέα
Φουμαρικό οξύ
Ελληνικές ποικιλίες
Οίνος

description: Ο οίνος αποτελείται από πολλά και διαφορετικής φύσης συστατικά. Η ανάγκη της χημικής του ανάλυσης είχε ως αποτέλεσμα την ανάπτυξη των ενόργανων τεχνικών αναλύσεων, για τον προσδιορισμό των συστατικών του. Στην ενόργανη χημική ανάλυση η HPLC (Υγρή Χρωματογραφία Υψηλής Απόδοσης) είναι ένα από τα πιο διαδεδομένα αναλυτικά όργανα, που χρησιμοποιούνται για τον διαχωρισμό των συστατικών του υπό ανάλυση δείγματος. Η παρούσα πτυχιακή εργασία μελέτησε την ανάλυση των οργανικών οξέων στους οίνους από διαφορετικές ποικιλίες (Αγιωργίτικο, Μοσχοφίλερο και Σαββατιανό), χρησιμοποιώντας μια μέθοδο HPLC - DAD. Τα οργανικά οξέα παίζουν καθοριστικό ρόλο στην ποιότητα του οίνου, συμβάλλοντας στα οργανοληπτικά χαρακτηριστικά και στην σταθεροποίηση του χρώματος του. Το τρυγικό οξύ, το μηλικό οξύ και το κιτρικό οξύ, είναι οργανικά οξέα που προέρχονται από την σταφυλή, ενώ το ηλεκτρικό οξύ και το οξικό οξύ είναι προερχόμενα οργανικά οξέα της αλκοολικής ζύμωσης και το γαλακτικό οξύ προϊόν μεταβολισμού των γαλακτικών βακτηρίων και των ζυμών. Η τεχνική μέθοδος ανάλυσης HPLC είναι ευρέως γνωστή για την ευαισθησία της στον διαχωρισμό των συστατικών σε μικρό χρονικό διάστημα. Στόχος της εργασίας ήταν η μέτρηση των οργανικών οξέων σε οίνους που είχαν προστεθεί διαφορετικές ποσότητες φουμαρικού οξέος (300 και 600 mg/L), διαφορετικές ποσότητες μηλικού οξέος (1 και 3 gr/L) και γαλακτικά βακτήρια (Oennococcus oeni , Lactobacillus plantarum). Σύμφωνα με τον OIV, επιτρέπεται η προσθήκη φουμαρικού οξέος στον οίνο (από 300 έως 600 mg/L), για την αναστολή της ανάπτυξης των γαλακτικών βακτηρίων, εμποδίζοντας την πραγματοποίηση της μηλογαλακτικής ζύμωσης. Για την ποσοτικοποίηση των οργανικών οξέων έγιναν καμπύλες αναφοράς χρησιμοποιώντας πρότυπα διαλύματα των οργανικών οξέων (τρυγικό οξύ, μηλικό οξύ, κιτρικό οξύ, φουμαρικό οξύ, γαλακτικό οξύ, ηλεκτρικό οξύ και οξικό οξύ ). Η μέθοδος έκλουσης που χρησιμοποιήθηκε ήταν ισοκρατική, με κινητή φάση θειικό οξύ H2SO4 0,05M και ταχύτητα ροής 0,4 mL/min. Για την διαδικασία ανίχνευσης επιλέχθηκε ο ανιχνευτής συστοιχίας διόδων (DAD) και οι μετρήσεις έγιναν στο μήκος κύματος 210 nm. Η μέθοδος HPLC που χρησιμοποιήθηκε έδωσε ικανοποιητικά αποτελέσματα στον ποιοτικό έλεγχο όλων των οξέων, και αποδείχθηκε ικανή στην ποσοτικοποίηση του φουμαρικού και του μηλικού οξέος. Επίσης παρατηρήθηκε πως η προσθήκη του φουμαρικού οξέος μπορεί να σταματήσει τον μεταβολισμό των γαλακτικών βακτηρίων, με αποτέλεσμα να σταθεροποιηθεί η συγκέντρωση του μηλικού οξέος στα δείγματα.
title: Ψηφιακή αποθήκευση και ασφαλής μετάδοση βίντεο με τη χρήση Raspberry Pi για drone
title: Drone digital video storage and secure transmission for Raspberry Pi
titleType: AlternativeTitle
Creators: name: Κίτσος, Ευάγγελος
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2024
Subjects: Raspberry Pi
Κρυπτογράφηση
Ασφαλής μετάδοση
Python
Μη επανδρωμένα αεροσκάφη
Encryption
Secure transmission
Unmanned aerial vehicles

description: Από την αρχή της ανάπτυξης του πολιτισμού και της γραφής μέχρι και σήμερα δημιουργήθηκε η ανάγκη του περιορισμού της ροής πληροφοριών μεταξύ ομάδων ατόμων. Από την απλή απόκρυψη μηνυμάτων μέχρι την ολοκληρωτική τους κρυπτογράφηση, ο άνθρωπος εκτός από τη σωστή διανομή των πληροφοριών επιθυμούσε παράλληλα να εξαιρέσει συγκεκριμένες ομάδες από τη γνώση τους. Ακόμη περισσότερο, με την εκρηκτική ανάπτυξη και δημοφιλή αποδοχή των κινητών συσκευών και του Διαδικτύου, ο τρομερός όγκος πληροφορίας που μετακινούνταν ανά πάσα στιγμή αναζητούσε τρόπους σωστής διαχείρισης. Η κρυπτογράφηση δεδομένων δεν είναι κάτι καινούργιο. Από την αρχαιότητα μαίνεται η αντιπαράθεση μεταξύ κρυπτογράφων και κρυπταναλυτών, με τους μεν να προσπαθούν να διασφαλίσουν τα μηνύματα που θα ήθελαν να διανείμουν και με τους δε να εντείνουν τις προσπάθειές τους στην ανάλυση και τελική αποκάλυψή τους. Η επιστήμη της Κρυπτογραφίας εξελίχθηκε σε ιδιαίτερα δύσκολη και απαιτεί στιβαρό μαθηματικό υπόβαθρο και από τις δύο πλευρές. Στην πορεία αυτή, πολλά συστήματα και πολλοί αλγόριθμοι έχουν χρησιμοποιηθεί (και παρωχηθεί) για να κρατήσουν τα μηνύματα ασφαλή. Ο αλγοριθμος Rijndael (των Rijmen και Daemen), γνωστός ευρύτερα και ως AES (Advanced Encryption System) χρησιμοποιείται σήμερα ευρέως. Απαντάται σε κλειδιά router, σε βίντεο και εικόνες, σε ηχητικά μηνύματα και συνομιλίες αλλά και σε βάσεις δεδομένων. Η παρούσα διπλωματική εργασία επικεντρώνει το ενδιαφέρον της στη μελέτη της ασφαλή μετάδοσης δεδομένων ανάμεσα σε δύο υπολογιστές. Ειδικότερα, θα χρησιμοποιηθούν Single Board Computers Raspberry Pi, ένας εκ των οποίων προορίζεται να μεταφέρεται από drone και θα είναι εξοπλισμένος με κάμερα. Η κάμερα θα καταγράφει βίντεο το οποίο με τη δημιουργία του θα κρυπτογραφείται, με τα δύο αρχεία να παραμένουν στη συσκευή. Το κρυπτογραφημένο αρχείο θα μεταδίδεται μέσω socket στο σταθμό εδάφους, ο οποίος θα είναι ο άλλος υπολογιστής Raspberry Pi, που θα αποκρυπτογραφεί και θα αναπαράγει το βίντεο που αρχικώς κινηματογραφήθηκε.
Travisia Johnston 1840
Creators: name: Plathong, Jintana
name: Plathong, Sakanan
name: Salazar-Vallejo, Sergio I.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Polychaeta
Travisiidae
Travisia

description: Key to Travisia species of Indo-Pacific Ocean
(Modified from Rizzo & Salazar-Vallejo 2020)
1. Branchiae branched................................................................................... 2
– Branchiae cirriform................................................................................... 3
2. One type of anal cirri with 6–8 short cirri.................................. T. arborifera Fauvel, 1932; Indian Ocean
– Two types anal cirri, 6 digitiform alternating with 4 small short cirri... T. satunensis sp. nov.; Andaman coast, Indian Ocean
3. Mid-ventral groove present; first branchiae from chaetiger 2, 21 pairs; posterior lappets poorly developed, conspicuous; pygidium short........................................ T. thailandensis sp. nov.; Gulf of Thailand, Western Pacific
– Mid-ventral groove absent.............................................................................. 4
4. Body with 44–53 chaetigers; posterior parapodia not projected from lobes or lappets; pygidium with 7 anal papillae............................................................................. T. lithophila Kinberg, 1866; Australia
– Body with less than 40 chaetigers........................................................................ 5
5. Body with 39–40 chaetigers.................................................. T. japonica Fujiwara, 1933; Japan
– Body with 34–35 chaetigers.......... T. amoyanus Yang, Wu, Wang, Zhao, Hwang & Cai, 2022; China, south China Sea
– Body with less than 30 chaetigers........................................................................ 6
6. Body with 23 chaetigers; posterior parapodia barely projected into lateral lappets; pygidium pigmented.......................................................................................... T. horsti Caullery, 1944; Indonesia
– Body with 23–29 chaetigers............................................................................. 7
7. Body with 27 chaetigers...................................................... T. chinensis Grube, 1869; China
– Body with 20–25 chaetigers............................................................................. 8
8. Branchiae 19–20 pairs, last five segments achaetous................. T. sanrikuensis Kobayashi & Kojima, 2021; Japan
– Branchiae 22 pairs....................................... T. oksae Hartmann-Schröder & Parker, 1995; Australia
description: Published as part of Plathong, Jintana, Plathong, Sakanan & Salazar-Vallejo, Sergio I., 2023, Two new species of Travisiidae (Annelida, Sedentaria) from Thailand, pp. 351-371 in Zootaxa 5346 (4) on page 369, DOI: 10.11646/zootaxa.5346.4.1, http://zenodo.org/record/8390339
Novel 8-Methoxycoumarin-3-Carboxamides with potent anticancer activity against liver cancer via targeting caspase-3/7 and β-tubulin polymerization
Creators: name: Alzamami, Ahmad
name: Radwan, Eman M.
name: Abo‑Elabass, Eman
name: El Behery, Mohammed
name: Alshwyeh, Hussah Abdullah
name: Al-Olayan, Ebtesam
name: Altamimi, Abdulmalik S.
name: Attallah, Nashwah G. M.
name: Altwaijry, Najla
name: Jaremko, Mariusz
name: M. Saied, Essa
Publisher: name: Humboldt-Universität zu Berlin
Year: 2023
Subjects: subject: Liver cancer
subject: Coumarin analogues
subject: Antiproliferative activity
subject: Cell cycle arrest
subject: Apoptosis
subject: Flow cytometric analysis
subject: Caspase-3/7
subject: β-tubulin polymerization
subject: Molecular docking
subject: 540 Chemie und zugeordnete Wissenschaften

description: The article processing charge was funded by the Open Access Publication Fund of Humboldt-Universität zu Berlin.
description: In the present study, we explored the potential of coumarin-based compounds, known for their potent anticancer properties, by designing and synthesizing a novel category of 8-methoxycoumarin-3-carboxamides. Our aim was to investigate their antiproliferative activity against liver cancer cells. Toward this, we developed a versatile synthetic approach to produce a series of 8-methoxycoumarin-3-carboxamide analogues with meticulous structural features. Assessment of their antiproliferative activity demonstrated their significant inhibitory effects on the growth of HepG2 cells, a widely studied liver cancer cell line. Among screened compounds, compound 5 exhibited the most potent antiproliferative activity among the screened compounds (IC50 = 0.9 µM), outperforming the anticancer drug staurosporine (IC50 = 8.4 µM), while showing minimal impact on normal cells. The flow cytometric analysis revealed that compound 5 induces cell cycle arrest during the G1/S phase and triggers apoptosis in HepG2 cells by increasing the percentage of cells arrested in the G2/M and pre-G1 phases. Annexin V-FITC/PI screening further supported the induction of apoptosis without significant necrosis. Further, compound 5 exhibited the ability to activate caspase3/7 protein and substantially inhibited β-tubulin polymerization activity in HepG2 cells. Finally, molecular modelling analysis further affirmed the high binding affinity of compound 5 toward the active cavity of β-tubulin protein, suggesting its mechanistic involvement. Collectively, our findings highlight the therapeutic potential of the presented class of coumarin analogues, especially compound 5, as promising candidates for the development of effective anti-hepatocellular carcinoma agents.
Supplementary figure 1: Charts showing the proportions of the coarse CAM components during development (A-D) and bar graphs showing the absolute volumes of the major mesodermal components (E) from A Morphometric and stereological study of the chorioallantoic membrane of the developing ostrich (Struthio camelus australis) embryo: A light and transmission electron microscopy investigation
Creators: name: Mthombeni, Dzunani
name: Makanya, Andrew N.
name: Jimoh, Sikiru
name: Maina, John
Publisher: name: The Royal Society
Year: 2025
Subjects: classificationCode: 310404
subject: Evolution of developmental systems

description: A-D: As expected, mesoderm takes the greatest percentage throughout but its contribution is lowest at E16 (A) and highest at E37 (B). The percentages of the chorion remained slightly higher sthan that of the allantois but both parameters decreased steadily towards incubation day 37. E: The mesenchyme remained the largest component of the mesoderm followed by the arteries, then the veins and the lymphatics had the smallest volume. At the maturity of the CAM (E37), volumes of arteries and veins were evenly matched.
title: Απαιτήσεις και τεχνολογικές προκλήσεις για την μετάβαση στην 6η γενιά κινητών επικοινωνιών
title: Requirements and technological challenges for the transition to the sixth generation of mobile communication
titleType: AlternativeTitle
Creators: name: Ρήγας, Ανδρέας
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2024
Subjects: 5G
6G
Διαδίκτυο πραγμάτων
Τεχνητή νοημοσύνη
Ασύρματες επικοινωνίες
Εικονική πραγματικότητα
Επαυξημένη πραγματικότητα
Μηχανική μάθηση

description: Όταν τον 1966 στις ΗΠΑ άρχισε να προβάλλεται η σειρά Star Τrek, ίσως κανείς, τότε, δεν θα μπορούσε να φανταστεί ότι η μικρή ασύρματη συσκευή επικοινωνίας που χρησιμοποιούσαν οι ηθοποιοί, και εμφανιζόταν για πρώτη φορά και προφανώς δεν δούλευε, θα είχε τέτοια αποδοχή από τον κόσμο. Υπάρχουν περίπου 8 δις άνθρωποι στη γη και κυκλοφορεί υπερδιπλάσιος αριθμός συσκευών κινητής επικοινωνίας. Αυτό που σίγουρα ήταν αδύνατο να προβλεφθεί είναι η τρομερή τεχνολογική εξέλιξη στις ασύρματες επικοινωνίες και κυρίως στις απίστευτες εφαρμογές που έχουν ήδη υλοποιηθεί και στις εξωφρενικές υπηρεσίες που βρίσκονται στο στάδιο της σχεδίασης. Το αντικείμενο αυτής της εργασίας είναι μια μελέτη για τις τεχνολογίες που απαιτούνται για την μετάβαση στην 6η γενιά των ασύρματων επικοινωνιών και τις βασικότερες εφαρμογές που θα προκύψουν με την υλοποίηση αυτών των τεχνολογιών. Αρχικά, θα γίνει μία αναφορά - αναδρομή στις τέσσερεις πρώτες γενιές ασύρματων επικοινωνιών. Στη συνέχεια, μία μεγαλύτερη ανάλυση της τεχνολογίας 5G, πολλές πτυχές της οποίας αποτελούν την βάση εκκίνησης για την 6G. Κατόπιν, ακολουθεί ένας συσχετισμός των τεχνολογιών Industry 4.0 και 6G. Συγκεκριμένα, πρώτα γίνεται αναφορά στην τεχνολογία Industry 4.0 και μετά καταδεικνύεται η σχεδόν παράλληλη πορεία Industry 4.0 και 6G με αναφορά σε σχετιζόμενες τεχνολογίες. Στη συνέχεια, μία μεγαλύτερη ανάλυση των βασικότερων τεχνολογιών του 6G και μία εκτενή περιγραφή των βασικότερων εφαρμογών που έχουν προταθεί και βρίσκονται σε επεξεργασία στο τραπέζι της σχεδίασης. Η εργασία ολοκληρώνεται με την εξαγωγή ορισμένων συμπερασμάτων και αποτύπωση μελλοντικών προκλήσεων.
miR-203 promotes HaCaT cell overproliferation through targeting LXR-α and PPAR-γ
Creators: name: Xiao, Yueyuan
name: Wang, Haizhen
name: Wang, Chang
name: Zeng, Bijun
name: Tang, Xueyong
name: Zhang, Yujin
name: Peng, Youhua
name: Luo, Meijunzi
name: Huang, Pan
name: Yang, Zhibo
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Psoriasis is an immune-mediated chronic inflammatory skin disease. Keratinocyte hyperproliferation has been regarded as a significant event in psoriasis pathogenesis. Considering the vital role of miRNA-mediated mRNA repression in psoriasis pathogenesis, in the present study, we attempted to investigate the mechanism of keratinocyte overproliferation from the point of miRNA-mRNA regulation. Both online microarray expression profiles and experimental results indicated that the expression of LXR-α and PPAR-γ was downregulated in psoriasis lesion skin. LXR-α or PPAR-γ overexpression alone was sufficient to inhibit keratinocyte proliferation, decrease KRT5 and KRT14 protein levels and increase KRT1 and KRT10 protein levels. miR-203 negatively regulated LXR-α and PPAR-γ expression through direct targeting. miR-203 inhibition exerted the opposite effects to LXR-α or PPAR-γ overexpression on HaCaT cells. More importantly, LXR-α or PPAR-γ overexpression could markedly remarkably attenuate the effects of miR-203 overexpression in keratinocytes, indicating that miR-203 promotes keratinocyte proliferation by targeting LXR-α and PPAR-γ. In conclusion, the miR-203-LXR-α/PPAR-γ axis modulates the proliferation of keratinocytes and might be a novel target for psoriasis treatment, which needs further in vivo investigation.
Hsa_circ_0009910: oncogenic circular RNA targets microRNA-145 in ovarian cancer cells
Creators: name: Li, Ying
name: Lin, Shuang
name: An, Na
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Statistics
subject: FOS: Mathematics
subject: Mental Health
subject: Hematology

description: Circular RNAs (circRNAs) correlate with cancer cell phenotypes. Particularly, circRNAs mediate the cancer process as microRNAs (miRNAs) sponges. This study was to ascertain the roles of hsa_circ_0009910 in phenotypic aspects of ovarian cancer cells. Mantel-Cox test was performed to analyze the correlation between hsa_circ_0009910 and survival outcomes of ovarian cancer. Minigene reporter was constructed and small interfering-RNA was designed for constructing hsa_circ_0009910-dysregulated and miR-145-upregulated cells identified by qRT-PCR. Proliferative and motile activities were monitored by CCK and Transwell. Western blot was applied for quantification of cyclin D1, CDK4, CDK6, MMP-2, MMP-9, IκBα, p65, Notch1, Hes1, and Hes5. miRNAs targets were predicted using a bioinformatics tool and confirmed using qRT-PCR and Dual-Luciferase reporter assay. Hsa_circ_0009910 was correlated with the poor prognosis of ovarian cancer patients. The ovarian cancer cell phenotypes were promoted by hsa_circ_0009910 while repressed by silencing hsa_circ_0009910. Hsa_circ_0009910 silence was responsible for the upregulation of the predicted miRNAs targets. Thereinto, miR-145 was confirmed as a miRNA target and negatively regulated by hsa_circ_0009910. miR-145 nullified the biological function of hsa_circ_0009910 in the proliferative and motile phenotypes, and the active status of NF-κB and Notch. Hsa_circ_0009910, representing unfavorable prognosis, induced proliferative and motile phenotypes by suppressing miR-145 in ovarian cancer cells.
Supplementary tables S1-S6 from A Morphometric and stereological study of the chorioallantoic membrane of the developing ostrich (Struthio camelus australis) embryo: A light and transmission electron microscopy investigation
Creators: name: Mthombeni, Dzunani
name: Makanya, Andrew N.
name: Jimoh, Sikiru
name: Maina, John
Publisher: name: The Royal Society
Year: 2025
Subjects: classificationCode: 310404
subject: Evolution of developmental systems

description: Tables showing raw data for egg mass, egg volume, embryo mass and CAM volume.
MiR-501-5p alleviates cardiac dysfunction in septic patients through targeting NR4A3 to prevent its binding with Bcl-2
Creators: name: Gao, Lan
name: Zhai, Zhongjie
name: Shi, Qindong
name: Yan, Jinqi
name: Zhou, Linjing
name: Wu, Yongxin
name: Zeng, Qinjing
name: Tian, Gang
name: Li, Hao
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Hematology

description: Sepsis-induced myocardial dysfunction is a common complication in septic patients. To date, a limited number of biomarkers that could predict cardiomyocyte apoptosis have been explored. In this study, we successfully established a cecal ligation and puncture (CLP)-induced septic model, and it was found that miR-501-5p expression was down-regulated in peripheral blood samples of septic patients with cardiac dysfunction, lipopolysaccharide (LPS)-induced cardiomyocytes, and the myocardium and peripheral blood in the septic model. Moreover, it was revealed that miR-501-5p overexpression could increase left ventricular diastolic pressure (LVDP), fractional shortening (FS), ejection fraction (EF), and maximum rate of the rise of left ventricular pressure (+dp/dt) in vivo, while it decreased the levels of myocardial injury-related indicators. In addition, LPS induction accelerated apoptosis and elevated the inflammation in HL-1 and HCM cells, which could be reversed by miR-501-5p overexpression. Mechanistically, we considered nuclear receptor subfamily 4 group A member 3 (NR4A3) as the target of miR-501-5p, and it was found that miR-501-5p prevented the binding between NR4A3 and Bcl-2. It was found that miR-501-5p exerted an inhibitory effect on cardiomyocyte apoptosis and inflammation in a NR4A3-dependent manner. Overall, our results may provide evidence for consideration of miR-501-5p in the therapy of sepsis.
title: S/V YOKOSUKA Cruise report YK24-10S
Creators: name: Akizawa, Norikatsu
Publisher: name: JAMSTEC
Year: 2024
Subjects: subject: Cruise report
subject: S/V YOKOSUKA
subject: oceans

description: [CRUISE REPORT]
 This document is a preliminary report of YK24-10S on S/V YOKOSUKA from 2024-06-20 to 2024-06-29.
RETRACTED ARTICLE: Knockdown of RNF183 suppressed proliferation of lung adenocarcinoma cells via inactivating the STAT3 signaling pathway
Creators: name: Ye, Guangbin
name: Luo, Hongcheng
name: Zhang, Tingting
name: Lan, Tianshu
name: Ling, Bo
name: Qi, Zhongquan
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy

description: We, the Editors and Publisher of the Cell Cycle journal, have retracted the following article: Guangbin Ye, Hongcheng Luo, Tingting Zhang, Tianshu Lan, Bo Ling and Zhongquan Qi. Knockdown of RNF183 suppressed proliferation of lung adenocarcinoma cells via inactivating the STAT3 signaling pathway. Cell Cycle. 2022;21(9):948-960. doi: 10.1080/15384101.2022.2035617 Since publication, significant concerns have been raised about the integrity of the data and reported results in the article. When approached for an explanation, the authors reviewed their data and confirmed there are errors present. The authors kindly provided their data, however, review of the data confirmed that the concerns remained. As verifying the validity of published work is core to the integrity of the scholarly record, we are therefore retracting the article. The authors have agreed to retract the article. We have been informed in our decision-making by our editorial policies and the COPE guidelines. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as ‘Retracted’.
Nonclassical properties of a state generated by a driven dispersive interaction
Creators: name: Kumar, Naveen
name: Chatterjee, Arpita
Publisher: name: arXiv
Year: 2024
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences
subject: 81V80

description: We consider a cavity field state, which is created by the atom-cavity field's interaction in the presence of a driven field. The two-level atom passes through the cavity and is driven by a weak classical field. A photon number dependent Stark shift is induced by the atom's dispersive interaction with the cavity field. When the atom is in excited state $|a\rangle$, the output cavity field thus obtained is taken into consideration. With the help of the state evaluated, we investigate different statistical properties such as photon number distribution, Wigner function, Mandel's $Q$ parameter and squeezing.
description: 8 pages, 4 figures
Hermippus Simon 1893
Creators: name: Sankaran, Pradeep M.
name: Jobi, Malamel J.
name: Joseph, Mathew M.
name: Sebastian, Pothalil A.
Publisher: name: Zenodo
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Zodariidae
Hermippus

description: Hermippus Simon, 1893
Hermippus Simon, 1893a: 424, 1893d: 316, 1905a: 172; Strand, 1906b: 668; Lessert, 1938: 432, 1938: 433; Lawrence, 1942: 146; Jocqué, 1986a: 10, 13, 15, 17, 18 & 19, Jocqué, 1987b: 110, Jocqué, 1989: 105. Hermippoides Gravely, 1921a: 407
The genus Hermippus, which is considered a senior synonym of Hermippoides Gravely, 1921 (Jocqué 1991), was erected by Simon in 1893. The genus was revised by Jocqué (1986) and is currently having nine valid species, seven African and two Oriental ones. Of these, three are known only from males, one is known only from female and the rest are known from both sexes (Platnick 2014). The occurrence of the genus Hermippus in India was first noticed by Simon in 1905. In 1921, Gravely reported a second species for which he raised the genus Hermippoides, which is later synonymised with Hermippus by Jocqué (1991). Presently the genus has two representatives in India, H. cruciatus Simon, 1905, which is reported from Sri Lanka also (Jocqué 1989) and H. arjuna Gravely, 1921.
Type species: Hermippus loricatus Simon, 1893 by original designation.
Redefinition and diagnosis. Medium to large sized spiders (6.5–15 mm) (Jocqué 1986). Prosoma broad and dome-shaped without cervical groove and with a fine fovea; the lateral margins of both cephalic and thoracic regions lie more or less in a single plane so that the separation between cephalic and thoracic region is less prominent. Eyes in two rows, both procurved; laterals placed far away from medians; medians lie very close to each other. Chilum well developed. Tarsi laterally compressed, with paired rows of short ventral spines, with two claws and claw tufts; metatarsi and tarsi rebordered; fourth leg always the longest; leg formula 4213 or 4321. Opisthosoma oval with characteristic pattern; males with/ without dorsal scutum. Male palp with small membranous area supporting TA; palpal tibia with unusually modified apophysis/apophyses; cymbium with short ventro-lateral spines, with proximo-lateral flange or ‘wing’ for supporting the main tibial apophysis; embolus long, filiform; conductor long, well developed; TA short. Epigyne simple, with median septum, with wide, medially placed copulatory openings; internal duct system highly sclerotized without complex convolution. [For more details, see Jocqué 1986].
Distribution. Africa, India, Sri Lanka (Platnick 2014).
description: Published as part of Sankaran, Pradeep M., Jobi, Malamel J., Joseph, Mathew M. & Sebastian, Pothalil A., 2014, On the genus Hermippus Simon, 1893 (Araneae: Zodariidae, Zodariinae) in India with the description of three new species from the Western Ghats and proposing a new biogeographical hypothesis for the distribution of the genus, pp. 114-126 in Zootaxa 3893 (1) on page 115, DOI: 10.11646/zootaxa.3893.1.5, http://zenodo.org/record/230449
Knockdown of RNF183 suppressed proliferation of lung adenocarcinoma cells via inactivating the STAT3 signaling pathway
Creators: name: Ye, Guangbin
name: Luo, Hongcheng
name: Zhang, Tingting
name: Lan, Tianshu
name: Ling, Bo
name: Qi, Zhongquan
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Computational Biology

description: Proteins of the RNF183 (RING finger 183) family proteins have been reported to be of great importance in tumor the initiation and progression. However, the biological role and regulatory mechanism of RNF183 in non small cell lung cancer (NSCLC) development and progression are poorly defined. Hence, lung adenocarcinoma (LUAD) cell proliferation, cell apoptosis and cell cycle were measured using Cell Counting Kit-8 and flow cytometry analysis, respectively. The correlation between RNF183 and SHP2 (Src homology-2 domain-containing protein tyrosine phosphatase) was measured using coimmunoprecipitation and ubiquitination analysis in vitro. Tumor growth of NSCLC cells in vivo was measured using the nude mouse xenograft model. In this study, we verify that elevated RNF183 expression in tumor tissues of LUAD, origin from the TCGA, GEPIA, TIMER, and UALCAN database. RNF183 regulates apoptosis and cell cycle in vitro and tumor growth in vivo by activating the STAT3 pathway through ubiquitination of SHP2, a negative feedback regulator of the STAT3 pathway. Taken together, our results demonstrate that RNF183 regulates proliferation, apoptosis, and cell cycle in LUAD cells via modulation of SHP2/STAT3 signaling, suggesting the potential for targeting the RNF183-SHP2/STAT3 pathway for use in LUAD treatment.
title: Μελέτη περίπτωσης επισήμανσης υποκατάστατων ζωικών προϊόντων
title: Case study on the labelling of animal products substitutes
titleType: AlternativeTitle
Creators: name: Ευσταθίου, Ναταλία
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2024
Subjects: Animal products
Plant products
Substitutes
Regulation 1169
Ζωικά προϊόντα
Φυτικά προϊόντα
Υποκατάστατα
Νομοθεσία 1169

description: Το μέλλον των φυτικών προϊόντων χαρακτηρίζεται από αναδυόμενες τάσεις, όπως η εξατομίκευση, η επιστημονική επικύρωση, η βιωσιμότητα και η ψηφιακή ενσωμάτωση. Οι καταναλωτές αναζητούν εξατομικευμένες φυτικές θεραπείες με επικυρωμένη αποτελεσματικότητα και ηθική προέλευση. Η συνεχής παρακολούθηση των πρακτικών επισήμανσης είναι ζωτικής σημασίας, διασφαλίζοντας την ακρίβεια των συστατικών, τις δηλώσεις αλλεργιογόνων και την τήρηση των εξελισσόμενων κανονισμών. Η διαφάνεια είναι ζωτικής σημασίας, η οποία διευκολύνεται από πιστοποιήσεις τρίτων και την πρόσβαση των καταναλωτών σε ολοκληρωμένες πληροφορίες. Η συνεργασία με τους επαγγελματίες υγείας και η αυτορρύθμιση του κλάδου ενισχύουν περαιτέρω την ασφάλεια των προϊόντων και την εμπιστοσύνη. Καθώς η αγορά φυτικών προϊόντων εξελίσσεται, ένα διαφανές και ενημερωμένο οικοσύστημα είναι απαραίτητο για την ικανοποίηση των απαιτήσεων των καταναλωτών και την προώθηση της ευημερίας.
miR-762 regulates the proliferation and differentiation of retinal progenitor cells by targeting NPDC1
Creators: name: Gao, Huiqin
name: Ni, Ni
name: Zhang, Dandan
name: Wang, Yuyao
name: Tang, Zhimin
name: Sun, Na
name: Ju, Yahan
name: Dai, Xiaochan
name: Zhang, Yidan
name: Liu, Yan
name: Gu, Ping
Publisher: name: Taylor & Francis
Year: 2020
Subjects: Medicine
Cell Biology
Molecular Biology
Neuroscience
Biological Sciences not elsewhere classified
Developmental Biology
Hematology

description: Retinal degenerations, which lead to irreversible decline in visual function, are still no effective recovery treatments. Currently, retinal progenitor cell (RPC) transplantation therapy is expected to provide a new approach to treat these diseases; however, the limited proliferation capacity and differentiation potential toward specific retinal neurons of RPCs hinder their potential clinical applications. microRNAs have been reported to serve as important regulators in the cell fate determination of stem/progenitor cells. In this study, our data demonstrated that miR-762 inhibited NPDC1 expression to positively regulate RPC proliferation and suppress RPC neuronal differentiation. Furthermore, the knockdown of miR-762 upregulated NPDC1 expression in RPCs, leading to the inhibition of RPC proliferation and the increase in neuronal differentiation. Moreover, NPDC1 could rescue anti-miR-762-induced RPC proliferation deficiency and the inhibitory effect of miR-762 on RPC differentiation. In conclusion, our study demonstrated that miR-762 plays a crucial role in regulating RPC proliferation and differentiation by directly targeting NPDC1, which is firstly reported that microRNAs positively regulate RPC proliferation and negatively regulate RPC differentiation, which provides a comprehensive understanding of the molecular mechanisms that dominate RPC proliferation and differentiation in vitro.
Diseño de un sistema de información para la gestión de recaudo mediante herramientas tecnológicas en la Subdirección de Cobro Tributario de la Secretaría Distrital de Hacienda
Creators: name: Guerrero Bermúdez, Cristian Andrés
name: Vásquez Forero, Jhon Alexander
Publisher: name: Universidad Externado de Colombia
Year: 2023
Subjects: subject: Sector público
subject: Adminstración de sistemas de información
subject: Impuestos - Aspectos económicos
subject: Gestión
subject: Sistema de información
subject: Tecnología
subject: Tributación

description: La cantidad de datos de gestión cobro de la Subdirección de Cobro Tributario (SCT) crece diariamente, aunado a lo anterior, la necesidad de la unificación de fuentes de datos, completitud, corrección y exactitud, hacen necesario identificar las diferentes herramientas tecnológicas que permitan generar información relevante que ayude en el proceso de toma de decisiones y reducción de tiempos de respuesta a los diferentes requerimientos de los contribuyentes de la ciudad de Bogotá, D.C. De acuerdo con lo anterior, se plantea el diseño de un sistema de información para la gestión de recaudo soportado en un marco referencial, dentro del cual, se exponen las principales metodologías para la gestión de la calidad de los datos, sistemas de información y herramientas tecnológicas requeridas para la construcción de este. Los principales resultados de este trabajo de grado revelan que, los funcionarios de la Subdirección de Cobro Tributario ratificaron la alta criticidad en el manejo de los datos, por lo tanto, se plantea un diseño de arquitectura de alto nivel, especificaciones funcionales, tipos de reporte y funcionalidades que debe contener el sistema de información, para finalmente, desarrollar un cronograma y análisis financiero orientado a su implementación.
description: The amount of collection management data of the Subdireccion de Cobro Tributario (SCT) grows daily, and in addition to this, the need to unify data sources, completeness, correctness and accuracy, make it necessary to identify the different technological tools to generate relevant information to assist in the decision making process and reduce response times to the different requirements of taxpayers in the city of Bogota, D.C. In accordance with the above, the design of an information system for collection management supported by a referential framework is proposed, within which the main methodologies for data quality management, information systems and technological tools required for the construction of this system are presented. The main results of this degree work reveal that the officials of the Subdireccion de Cobro Tributario ratified the high criticality in data management, therefore, a high-level architecture design, functional specifications, types of reports and functionalities that the information system must contain are proposed, to finally develop a schedule and financial analysis oriented to its implementation.
Gestión de experiencia de usuario en el área de performance marketing de eficiencias y servicios del Grupo Nexarte
Creators: name: Isaza Peña, Diana Maritza
name: Beltrán Sotelo, César
Publisher: name: Universidad Externado de Colombia
Year: 2023
Subjects: subject: Administración de mercadeo
subject: Planificación - Contratos y especificaciones
subject: Mercadeo - Costos
subject: Experiencia de usuario
subject: Performance marketing
subject: Servicio al cliente
subject: Modelo de diseño de experiencias
subject: Mapa de empatía

description: Este trabajo se enfocará en la nueva unidad de negocio performance marketing, que tiene como objetivo generar al 2025, una utilidad bruta de 5.180 millones acumulados, a través de la generación de leads calificados, que conlleven al cierre comercial de productos o servicios para los clientes, cobrando únicamente un costo por adquisición (CPA) hacia el cliente que contrató el servicio. Todo lo anterior, bajo la premisa de que los esfuerzos deben estar apuntando a un enfoque centrado en el cliente, con un modelo de servicio que supere las expectativas del mercado, haciéndolos más competitivos, sostenibles y que los haga posicionar como referentes y generadores de valor en el sector. En este sentido, los resultados que se mostrarán en este trabajo está enfocados en generar un modelo de experiencia de usuario que nos permita mejorar el área de performance marketing de Eficiencias y Servicios.
description: This work will focus on the new performance marketing business unit, which aims to generate a gross profit of 5,180 million accumulated by 2025, through the generation of qualified leads, which lead to the commercial closure of products or services for clients, charging only a cost per acquisition (CPA) to the client who contracted the service. All of the above, under the premise that efforts must be aimed at a customer-centered approach, with a service model that exceeds market expectations, making them more competitive, sustainable and positioning them as references and generators of value. in the sector. In this sense, the results that will be shown in this work are focused on generating a user experience model that allows us to improve the marketing performance area of Efficiencies and Services.
title: Γεωφυσική διασκόπηση σε αγροτεμάχιο στην θέση “Κιτέζα - Κάλμη” Λαγονησίου - Δήμου Σαρωνικού
title: Geophysical survey in private plot at "Kiteza - Kalmi" Lagonisiou - Municipality of Saronikos
titleType: AlternativeTitle
Creators: name: Γκρόσιος, Γεώργιος
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2024
Subjects: Ηλεκτρική τομογραφία
Γεωφυσικές διασκοπήσεις
Ειδική ηλεκτρική αντίσταση
Αρχαία ευρήματα

description: Αντικείμενο της παρούσας διπλωματικής εργασίας είναι η διερεύνηση της ύπαρξης ή μη θαμμένων αρχαίων αρχιτεκτονικών λειψάνων και την κατά το δυνατόν απεικόνισή τους κάνοντας γεωφυσικές διασκοπήσεις με τη χρήση της μεθόδου της ηλεκτρικής τομογραφίας. Από τα αποτελέσματα εντοπίστηκαν ανωμαλίες στην κατανομή της ειδικής ηλεκτρικής αντίστασης, οι οποίες δεν παρουσιάζουν χαρακτηριστικά που να δύναται να θεωρηθούν ότι αποτελούν ενδείξεις αρχαιολογικών λειψάνων. Επιπρόσθετα και με βάση τις ενδείξεις της επιφάνειας αλλά και στοιχείων από το απόσπασμα του εγκεκριμένου ρυμοτομικού σχεδίου, όλες οι ενδείξεις συνηγορούν ότι πρόκειται είτε για υπολείμματα πρόσφατων κατασκευών είτε για ίχνη παρελθοντικής βλάστηση.
Análisis y mejoramiento del modelo de gestión de conocimiento enfocado en el área de tecnologías e información de la Secretaría Distrital de Gobierno de Bogotá
Creators: name: Gómez Torres, José Misael
Publisher: name: Universidad Externado de Colombia
Year: 2023
Subjects: subject: Conocimiento - Metodos
subject: Población - Análisis
subject: Innovaciones tecnológicas
subject: Gestión del conocimiento
subject: Innovación
subject: Tácito
subject: Explicito

description: Campo de investigación: Gestión del Conocimiento. objetivo: Diseñar y proponer un modelo de gestión del conocimiento, específicamente adaptado para la Dirección de Tecnologías de la Información (DTI) de la Secretaría de Distrital de Gobierno (SDG). Metodología utilizada: Se utilizo el método deductivo. Se aplicaron conceptos estudiados y aplicados a la solución de un caso particular, debido a que lo que se pretende con el proyecto es evaluar el estado actual de la gestión del conocimiento en la DTI y, con base en la información recolectada, diseñar un modelo que permita una adecuada gestión de este. La pregunta de investigación: ¿cómo realizar una adecuada gestión del conocimiento en la DTI de la SDG que permita la innovación a través de servicios cada vez más eficientes y rápidos?, se formula un modelo que identifica cuatro ejes principales propuestos por los diferentes autores y dos transversales que acompañan el modelo. Conclusiones: El sector público tiene una dinámica especial y por ello requiere que el manejo de la información y el conocimiento que se produce deba tener un tratamiento acorde con esa necesidad, los colaboradores muestran especial interés por la gestión del conocimiento, sin embargo, también evidencian desconocimiento sobre como implementarlo o hacerlo practico.
description: Research field: Knowledge Management. Objective: Design and propose a knowledge management model, specifically adapted for the Information Technology Department (DTI) of the District Government Secretariat (SDG). Methodology used: The deductive method was used. Concepts studied and applied to the solution of a particular case were applied, because what is intended with the project is to evaluate the current state of knowledge management in the DTI and, based on the information collected, design a model that Allow proper management of it. The research question: how to carry out an adequate knowledge management in the DTI of the SDG that allows innovation through increasingly efficient and fast services? a model is formulated that identifies four main axes proposed by the different authors and two transversals that accompany the model. Conclusions: The public sector has a special dynamic and therefore requires that the management of the information and knowledge that is produced must be treated in accordance with this need, the collaborators show special interest in knowledge management, however, they also show lack of knowledge on how to implement it or make it practical.
Cyclin E and Cdk1 regulate the termination of germline transit-amplification process in Drosophila testis
Creators: name: Gadre, Purna
name: Chatterjee, Shambhabi
name: Varshney, Bhavna
name: Ray, Krishanu
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: An extension of the G1 is correlated with stem cell differentiation. The role of cell cycle regulation during the subsequent transit amplification (TA) divisions is, however, unclear. Here, we report for the first time that in the Drosophila male germline lineage, the transit amplification divisions accelerate after the second TA division. The cell cycle phases, marked by Cyclin E and Cyclin B, are progressively altered during the TA. Antagonistic functions of the bag-of-marbles and the Transforming-Growth-Factor-β signaling regulate the cell division rates after the second TA division and the extent of the Cyclin E phase during the fourth TA division. Furthermore, loss of Cyclin E during the fourth TA cycle retards the cell division and induces premature meiosis in some cases. A similar reduction of Cdk1 activity during this stage arrests the penultimate division and subsequent differentiation, whereas enhancement of the Cdk1 activity prolongs the TA by one extra round. Altogether, the results suggest that modification of the cell cycle structure and the rates of cell division after the second TA division determine the extent of amplification. Also, the regulation of the Cyclin E and CDK1 functions during the penultimate TA division determines the induction of meiosis and subsequent differentiation.
IRIS : chatbot con inteligencia artificial para la gestión de procesos empresariales
Creators: name: Cabezas Garzón, Jenny Paola
name: Castañeda Herrera, Nicolas
Publisher: name: Universidad Externado de Colombia
Year: 2023
Subjects: subject: Comunicación en adninistración
subject: Recursos humanos
subject: Innovaciones tecnológicas
subject: Chat Bot
subject: Inteligencia artificial
subject: Gestión de procesos
subject: Comunicación organizacional interna
subject: Claridad y visibilidad

description: El presente trabajo busca lograr claridad, comunicación y visibilidad en la gestión de procesos de una empresa de servicios médicos en el menor tiempo optimizando la toma de decisiones. Teniendo en cuenta lo anterior se analizará desde el punto de vista organizacional cada uno de los componentes mencionados, y cómo estos impactan positiva o negativamente a cada área en el desarrollo de su labor al no estar correctamente ejecutados con el fin de diseñar un chatbot con inteligencia artificial que satisfaga estas necesidades internas contribuyendo a la eficiencia y productividad de la compañía. El chatbot es una herramienta diseñada acorde a las necesidades identificadas en cada área impactada dentro de la gestión de procesos de la organización analizada, siendo un factor clave el diseño, desarrollo y éxito de su implementación.
description: This tesis seeks to find clarity, communication, and visibility in the process management of a company of health care services and at the same time by saving time and enhancing the decision process. Considering the mentioned ideas, the tesis will analyze from the organizational point of view every single one of the mentioned components and how they impact in a positive or negative way each department of the company and their performance by no being properly executed. The idea is to design a chatbot with artificial intelligence that solves the needs of the company and contributes to the productivity and efficiency of the company. The chatbot is a tool designed according to the issues identified per department within the scope of the process management of the company analyzed being a success factor the design, development and the appropriate implementation.
Polo-like kinase 1 (Plk1) is a positive regulator of DNA replication in the Xenopus in vitro system
Creators: name: Ciardo, Diletta
name: Haccard, Olivier
name: Narassimprakash, Hemalatha
name: Chiodelli, Virginie
name: Goldar, Arach
name: Marheineke, Kathrin
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Science Policy
subject: Developmental Biology
subject: Cancer

description: Polo-like kinase 1 (Plk1) is a cell cycle kinase essential for mitosis progression, but also important for checkpoint recovery and adaptation in response to DNA damage and replication stress. However, although Plk1 is expressed in S phase, little is known about its function during unperturbed DNA replication. Using Xenopus laevis egg extracts, mimicking early embryonic replication, we demonstrate that Plk1 is simultaneously recruited to chromatin with pre-replication proteins where it accumulates throughout S phase. Further, we found that chromatin-bound Plk1 is phosphorylated on its activating site T201, which appears to be sensitive to dephosphorylation by protein phosphatase 2A. Extracts immunodepleted of Plk1 showed a decrease in DNA replication, rescued by wild type recombinant Plk1. Inversely, modest Plk1 overexpression accelerated DNA replication. Plk1 depletion led to an increase in Chk1 phosphorylation and to a decrease in Cdk2 activity, which strongly suggests that Plk1 could inhibit the ATR/Chk1-dependent intra-S phase checkpoint during normal S phase. In addition, we observed that phosphorylated Plk1 levels are high during the rapid, early cell cycles of Xenopus development but decrease after the mid-blastula transition when the cell cycle and the replication program slow down along with more active checkpoints. These data shed new light on the role of Plk1 as a positive regulating factor for DNA replication in early, rapidly dividing embryos.