cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A Theoretical Model of the Wnt Signaling Pathway in the Epithelial Mesenchymal Transition
Creators: name: Gasior, Kelsey
Publisher: name: BioMed Central
Year: 2017

description: Abstract Background Following the formation of a primary carcinoma, neoplastic cells metastasize by undergoing the epithelial mesenchymal transition (EMT), which is triggered by cues from inflammatory and stromal cells in the microenvironment. EMT allows epithelial cells to lose their highly adhesive nature and instead adopt the spindle-like appearance, as well as the invasive and migratory behavior, of mesenchymal cells. We hypothesize that a bistable switch between the epithelial and mesenchymal phenotypes governs EMT, allowing the cell to maintain its mesenchymal phenotype even after it leaves the primary tumor microenvironment and EMT-inducing extracellular signal. Results This work presents a simple mathematical model of EMT, specifically the roles played by four key proteins in the Wnt signaling pathway: Dishevelled (Dvl), E-cadherin, β-catenin, and Slug. The model predicts that following activation of the Wnt pathway, an epithelial cell in the primary carcinoma must attain a threshold level of membrane-bound Dvl to convert to the mesenchymal-like phenotype and maintain that phenotype once it has migrated away from the primary tumor. Furthermore, sensitivity analysis of the model suggests that in both the epithelial and the mesenchymal states, the steady state behavior of E-cadherin and the transcription factor Slug are sensitive to changes in the degradation rate of Slug, while E-cadherin is also sensitive to the IC50 (half-maximal) concentration of Slug necessary to inhibit E-cadherin production. The steady state behavior of Slug exhibits sensitivity to changes in the rate at which it is induced by β-catenin upon activation of the Wnt pathway. In the presence of sufficient amount of Wnt ligand, E-cadherin levels are sensitive to the ratio of the rate of Slug activation via β-catenin to the IC50 concentration of Slug necessary to inhibit E-cadherin production. Conclusions The sensitivity of E-cadherin to the degradation rate of Slug, as well as the IC50 concentration of Slug necessary to inhibit E-cadherin production, shows how the adhesive nature of the cell depends on finely-tuned regulation of Slug. By highlighting the role of β-catenin in the activation of EMT and the relationship between E-cadherin and Slug, this model identifies critical parameters of therapeutic concern, such as the threshold level of Dvl necessary to inactivate the GSK-3β complex mediating β-catenin degradation, the rate at which β-catenin translocates to the nucleus, and the IC50 concentration of Slug needed to inhibit E-cadherin production.
Determination und menschliche Freiheit. Die Theodizeefrage der Stoa und bei Leibniz
Creators: name: Schneider, Joachim Helmut
Publisher: name: Universität Tübingen
Year: 2018
Subjects: subject: Theodizee , Leibniz, Gottfried Wilhelm , Stoa , Philosophie , Gottesvorstellung , Theismus , Determinismus , Freiheit , Übel
subject: 100
subject: 230
subject: Theodicy
subject: Stoicism
subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: Comparison
subject: Concept of God
subject: Theism
subject: Determinism
subject: Freedom
subject: Will of God
subject: Evil

description: Das Spannungsverhältnis von menschlicher Freiheit und ursprünglichem Determinismus beschäftigt die europäische Ideengeschichte seit ihren Anfängen. Wie kommt »das Böse« in die »beste aller möglichen Welten«, fragt Gottfried Wilhelm Leibniz in seiner »Theodizee«. Die Oikeiosistheorie der Stoa lehrt den universellen Zwang als Ordnungsstruktur auf drei Ebenen a) der Selbsterhaltung, b) der Erhaltung der Nachkommenschaft und c) der Sozialfürsorge der Mitmenschen. Der Vergleich der Leibniz'schen und stoischen Philosophie bietet eine Orientierungshilfe, um die gegenwärtige Spannung von Bestimmtheit und freiem Willen besser zu verstehen.
EURO-CORDEX-CMIP6 RCM component description
Creators: name: EURO-CORDEX
Publisher: name: Zenodo
Year: 2023
Subjects: EURO-CORDEX
Regional Climate Model

description: This document provides an overview of the components of Regional Climate Models (RCMs) that are used in generating future regional climate change simulations for the EURO-CORDEX initiative under the CORDEX-CMIP6 protocol. The document is continuously updated by the modelling teams.
Adaptation to bipolar disorder and perceived risk to children: a survey of parents with bipolar disorder
Creators: name: Rosenstein, Donald L
Publisher: name: BioMed Central
Year: 2013

description: Abstract Background Bipolar disorder (BPD) is a common condition associated with significant morbidity and reduced quality of life. In addition to challenges caused by their mood symptoms, parents affected with BPD harbor concerns about the mental health of their children. Among adult parents who perceive themselves to have BPD, this study aims to examine participants’ coping methods; identify predictors of adaptation; assess parental perceptions of risks for mood disorders among their children; and describe the relationships among illness appraisals, coping, adaptation to one’s own illness, and perceived risk to one’s children. Methods Parents who self-identified as having BPD completed a web-based survey that assessed dispositional optimism, coping, perceived illness severity, perceived etiology of BPD, perceived risk to offspring, and adaptation to BPD. Participants had at least one unaffected child who was 30 years of age or below. Results 266 parents were included in the analysis. 87% of parents endorsed a “somewhat greater” or “much greater” risk for mood disorders in one’s child(ren) than someone without a family history. Endorsing a genetic/familial etiology to BPD was positively correlated with perceived risk for mood disorders in children (r s = .3, p < 0.01) and active coping with BDP (r = .2, p < 0.01). Increased active coping (β = 0.4, p < 0.001) and dispositional optimism (β = 0.3, p < 0.001) were positively associated with better adaptation, while using denial coping was negatively associated with adaptation (β = −0.3, p < 0.001). The variables explained 55.2% of the variance in adaptation (F = 73.2, p < 0.001). Coping mediated the effect of perceived illness severity on adaptation. Conclusions These data inform studies of interventions that extend beyond symptom management and aim to improve the psychological wellbeing of parents with BPD. Interventions targeted at illness perceptions and those aimed at enhancing coping should be studied for positive effects on adaptation. Parents with BPD may benefit from genetic counseling to promote active coping with their condition, and manage worry about perceived risk to their children.
Indirect exchange interaction between magnetic adatoms in graphene
Creators: name: Krainov, Igor
name: Rozhansky, Igor
name: Averkiev, Nikita
name: Lahderanta, Erkki
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We present a theoretical study of indirect exchange interaction between magnetic adatoms in graphene. The coupling between the adatoms to a graphene sheet is described in the framework of tunneling Hamiltonian. We account for the possibility of this coupling being of resonant character if a bound state of the adatom effectively interacts with the continuum of 2D delocalized states in graphene. In this case the indirect exchange between the adatoms mediated by the 2D carriers appears to be substantially enhanced compared to the results known from Ruderman-Kittel-Kasuya-Yosida (RKKY) theory. Moreover, unlike the results of RKKY calculations in the case of resonant exchange the magnetic coupling between the adatoms sitting over different graphene sublattices do not cancel each other. Thus, for a random distribution of the magnetic adatoms over graphene surface a non-zero magnetic interaction is expected. We also suggest an idea of controlling the magnetism by driving the tunnel coupling in and out of resonance by a gate voltage.
description: 7 pages, 4 figures
title: Le partage de valeurs dans les duos de coenseignants
title: Le partage de valeurs dans les duos de coenseignants
titleType: AlternativeTitle
Creators: name: Collet, Morgane
Publisher: name: Unknown
Year: 0
Subjects: subject: enseignement
subject: inclusion
subject: coenseignement
subject: collaboration
subject: valeurs
subject: facteurs individuels

description: Cette recherche prend place en Suisse, et plus particulièrement en Valais, où les prescriptions demandent à l’école de favoriser les prises en charge à visée inclusive d’enfants à besoins éducatifs particuliers. Pour ce faire, la collaboration entre enseignants réguliers et spécialisés est indispensable. Pour aller plus loin, le coenseignement (travail partagé de type coopératif) est une pratique permettant de viser cet idéal d’inclusion. Ainsi, je me suis questionnée sur les facteurs qui favorisaient la mise en place du coenseignement dans des classes, et je me suis attardée plus particulièrement sur les valeurs des enseignants qui travaillent ensemble. Les résultats de ma recherche révèlent que les enseignants accordent beaucoup d’importance aux facteurs individuels et interpersonnels, dont les valeurs. Selon elles, certaines valeurs seraient indispensables pour pouvoir créer une réelle relation de travail coopérative, comme la bienveillance, la tolérance, l’ouverture à l’autre, etc. Les valeurs mises en avant sont généralement tournées vers la recherche du bien-être des autres. Selon elles, d’autres valeurs sont à proscrire (comme le pouvoir) : ce sont celles qui induisent des relations inégales entre les deux enseignants du duo. Une certaine compatibilité entre les deux collègues semble, de même, influencer la relation de collaboration ou de coopération. Toutefois, d’autres facteurs semblent également extrêmement importants afin de pouvoir pratiquer le coenseignement dans les classes. Les facteurs organisationnels sont souvent relevés. Ainsi, discuter des valeurs, des attentes et des raisons pour lesquelles son collègue agit d’une certaine manière pourrait permettre de trouver des compromis afin de respecter les valeurs de chaque enseignant du duo. Si cela fonctionne, le coenseignement pourrait alors être pratiqué afin de répondre à l’injonction de la culture scolaire à visée inclusive.
Spin pairs in a weakly coupled many-electron quantum dot
Creators: name: Hellmüller, S.
name: Bischoff, D.
name: Müller, T.
name: Beck, M.
name: Ensslin, K.
name: Ihn, T.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We report the observation of an unusually large number of consecutive spin pairs in a weakly coupled many-electron GaAs/AlGaAs quantum dot. The pairs are identified due to pairwise parallel shifts of Coulomb resonances in a perpendicular magnetic field. Using a nearby quantum point contact for time-resolved charge detection, the tunneling rates are investigated as a function of gate voltage and magnetic field. We compare our experimental data to a single-level transport model and discuss possible reasons for deviations.
description: 7 pages, 4 figures
AN INTEGRATED FRAMEWORK FOR MODELING, ROBUST COORDINATED CONTROL, AND POWER MANAGEMENT OF ADVANCED POWERTRAINS FEATURING TURBOCHARGED ENGINES
Creators: name: Qiu, Weijin
Publisher: name: Purdue University Graduate School
Year: 2023
Subjects: classificationCode: 400205
subject: Hybrid and electric vehicles and powertrains
classificationCode: 400705
subject: Control engineering
classificationCode: 400702
subject: Automation engineering

description: Engine downsizing with the assistance of turbomachinery and/or energy storage system has been realized to be one of the most promising and cost-effective solutions in pursuit of cleaner and more efficient engine products. Fundamental challenges however, exist in terms of control and energy management of advanced powertrain featuring turbocharged engines due to their complex dynamics, inherent coupling nature, and strict emission regulations concerning environmental preservation. For the purpose of addressing those challenges, this dissertation develops an integrated framework for modeling, robust coordinated control, and power management of advanced powertrains featuring turbocharged engines.This dissertation first studies an advanced turbocharged lean-burn SI natural gas engine manufactured by Caterpillar, and develops an intuitive physics-based, control-oriented model. The obtained control-oriented model is validated against a high-fidelity truth-reference model and serves as the basis on which a robust coordinated control system is developed. The dissertation then proposes a comprehensive procedure for synthesizing a robust coordinated control system applying optimization-based H_infinity control theory. Specifically, this framework outlines a methodology of modeling uncertainties to account for system robustness, and providing valuable insights into the tuning of general coordinated control system design. For performance testing, the synthesized robust coordinated control system is implemented on the high-fidelity truth-reference model. A parallel closed-loop simulation strategy is adopted so that direct comparison between the robust coordinated control system and benchmark production control system (composed of multiple fine-tuned PID controllers) developed by Caterpillar can be carried out. Simulation results manage to demonstrate the merit of utilizing the robust coordinated control system, with better performances observed in terms of steady-state tracking, transient response, and disturbance attenuation.The second part of this dissertation focuses on the development of a proposed novel hybrid electric wheel loader which features a downsized engine assisted by turbocharger and an energy storage system. Research efforts documented in this dissertation involve system configuration, controller design (both component-level and supervisory-level), simulation development (both software-in-the-loop and hardware-in-the-loop) and simulated validation for the proposed novel wheel loader. Inspired by the successful simulation results, John Deere assembled a real demo vehicle with the proposed powertrain and conducted some in-field testing, from which encouraging experimental results are observed.
title: Fantasy as a mode in British and Irish literary decadence, 1885–1925
Creators: name: Mercurio, Jeremiah Romano
Publisher: name: University of St Andrews
Year: 2011

description: This Ph.D. thesis investigates the use of fantasy by British and Irish 'Decadent' authors and illustrators, including Oscar Wilde, Max Beerbohm, Aubrey Beardsley, 'Vernon Lee' (Violet Paget), Ernest Dowson, and Charles Ricketts. Furthermore, this study demonstrates why fantasy was an apposite form for literary Decadence, which is defined in this thesis as a supra-generic mode characterized by its anti-mimetic impulse, its view of language as autonomous and artificial, its frequent use of parody and pastiche, and its transgression of boundaries between art forms. Literary Decadence in the United Kingdom derives its view of autonomous language from Anglo-German Romantic philology and literature, consequently being distinguished from French Decadence by its resistance to realism and Naturalism, which assume language's power to signify the 'real world'. Understanding language to be inorganic, Decadent writers blithely countermand notions of linguistic fitness and employ devices such as catachresis, paradox, and tautology, which in turn emphasize the self-referentiality of Decadent texts. Fantasy furthers the Decadent argument about language because works of fantasy bear no specific relationship to 'reality'; they can express anything evocable within language, as J.R.R. Tolkien demonstrates with his example of "the green sun" (a phrase that can exist independent of the sun's actually being green). The thesis argues that fantasy's usefulness in underscoring arguments about linguistic autonomy explains its widespread presence in Decadent prose and visual art, especially in genres that had become associated with realism and Naturalism, such as the novel (Chapter 1), the short story (Chapter 3), drama (Chapter 4), and textual illustration (Chapter 2). The thesis also analyzes Decadents' use of a wholly non-realistic genre, the fairy tale (see Chapter 5), in order to delineate the consequences of their use of fantasy for the construction of character and gender within their texts.
Minimum-Time Cavity Optomechanical Cooling
Creators: name: Stefanatos, Dionisis
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Optimization and Control (math.OC)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: Optomechanical cooling is a prerequisite for many exotic applications promised by modern quantum technology and it is crucial to achieve it in short times, in order to minimize the undesirable effects of the environment. We formulate cavity optomechanical cooling as a minimum-time optimal control problem on anti-de Sitter space of appropriate dimension and use the Legendre pseudospectral optimization method to find the minimum time and the corresponding optimal control, for various values of the maximum coupling rate between the cavity field and the mechanical resonator. The present framework can also be applied to create optomechanical entanglement in minimum time and to improve the efficiency of an optomechanical quantum heat engine.
2nd Experiment Illusory Truth Effect and Social Political Opinion statements
Creators: name: Riesthuis, Paul
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Social and Behavioral Sciences

description: The current pre-registration is for a follow-up experiment of the previously pre-registered study (see https://osf.io/u67kg/). The results of the previous study showed that the illusory truth effect remained for true information and misinformation statements, and was actually enhanced when only comparing statements that were correctly encoded as a fact. However, we did not find evidence for such an effect for general opinion statements. As a matter of fact, our exploratory analyses showed a reversed illusory truth effect for general opinion statements when examining only the statements that were encoded correctly as an opinion. In our follow-up study, we want to examine whether we again find no illusory truth effect for general opinion statements. Moreover, we want to examine whether this null finding remains for social political opinions.
Latent class analysis suggests four distinct classes of complementary medicine users among women with breast cancer
Creators: name: Bradshaw, Patrick
name: Gammon, Marilie D.
name: Abrahamson, Page
Publisher: name: BioMed Central
Year: 2015

description: Abstract Background Breast cancer patients commonly report using >1 form of complementary and alternative medicine (CAM). However, few studies have attempted to analyze predictors and outcomes of multiple CAM modalities. We sought to group breast cancer patients by clusters of type and intensity of complementary and alternative medicine (CAM) use following diagnosis. Methods Detailed CAM use following breast cancer diagnosis was assessed in 2002–2003 among 764 female residents of Long Island, New York diagnosed with breast cancer in 1996–1997. Latent class analysis (LCA) was applied to CAM modalities while taking into account frequency and intensities. Results Four distinct latent classes of CAM use emerged: 1) “Low-dose supplement users” (40 %), who used only common nutritional supplements; 2) “Vitamin/mineral supplement users” (39 %), using an abundance of supplements in addition to other practices; 3) “Mind-body medicine users” (12 %), with near-universal use of supplements, mind-body medicine techniques, and massage; and 4) “Multi-modality high-dose users” (9 %), who were highly likely to use nearly all types of CAM. Predictors of membership in classes with substantial CAM use included younger age, more education, higher income, Jewish religion, ideal body mass index, higher fruit and vegetable intake, higher levels of physical activity, receipt of adjuvant chemotherapy, and prior use of oral contraceptives. Conclusions LCA identified important subgroups of breast cancer patients characterized by varying degrees of complementary therapy use. Further research should explore the reproducibility of these classes and investigate the association between latent class membership and breast cancer outcomes.
Practice Abstracts BRANCHES PROJECT H2020 - PA54
Creators: name: Berglund, Nora
Publisher: name: Zenodo
Year: 2023
Subjects: Data intermediation ser-vice, data economy, data ecosystem, efficiency, adding value

description: Tritom – data intermediation service for food chain operators
description: BRANCHES will produce and share more than 50 case studies, considered Best Practices. The selected case studies will be summarized in Practice Abstracts (PAs), documents tailored for practitioners, shared through the project media and collected on this webpage. The numbering of the PAs only refers to chronological order of uploading. Enjoy your reading!
Noise and dissipation on coadjoint orbits
Creators: name: Arnaudon, Alexis
name: Castro, Alex L.
name: Holm, Darryl D.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Dynamical Systems (math.DS)
subject: Mathematical Physics (math-ph)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We derive and study stochastic dissipative dynamics on coadjoint orbits by incorporating noise and dissipation into mechanical systems arising from the theory of reduction by symmetry, including a semidirect-product extension. Random attractors are found for this general class of systems when the Lie algebra is semi- simple, provided the top Lyapunov exponent is positive. We study two canonical examples, the free rigid body and the heavy top, whose stochastic integrable reductions are found and numerical simulations of their random attractors are shown.
Scholarly Serials & Published Online Heritage: Measuring What Is Kept
Creators: name: BEQUET, Gaëlle
name: Burnhill, Peter
Publisher: name: Zenodo
Year: 2024
Subjects: Preservation
Archiving
Serials
Registry
ISSN

description: The Keepers Registry is a global monitor of archival status for online continuing resources assigned with ISSN. Forming part of the ISSN Portal, it is available at https://keepers.issn.org ,

The purpose of the presentation is two-fold: to share knowledge of archiving reported into the Keepers Regstry; to encourage more archiving organisations to join the Registry.

The statistical information used is taken from a report to the Technical Advisory Committee for the Registry, compiled by Peter Burnhill, one of the authors of the presentation.

This shows significant progress in known archiving of 'scholarly titles' achieved from June 2012 to December 2023, but with larger variation across countries of publication; the highest Ingest Ratio is for countries which host the big commercial publishers. Very much less is known about the larger number of online continuing resources not indexed as scholarly - namely, the world's published heritage - the resources needed for scholarship and public understanding.

The presentation concludes with the objectives for the Registry included in the ISSN Strategy Organisations, including new Keepers, especially those from Asia, Africa and South America, which have mandates to be stewards of each nation's digital heritage; this being in line with The UNESCO/PERSIST Guidelines for the Selection of Digital Heritage for Long-Term Preservation. UNESCO (2021).
Crystal Field Excitations in Breathing Pyrochlore Antiferromagnet Ba3Yb2Zn5O11
Creators: name: Haku, T.
name: Soda, M.
name: Sera, M.
name: Kimura, K.
name: Itoh, S.
name: Yokoo, T.
name: Masuda, T.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Inelastic neutron scattering measurement is performed on a breathing pyrochlore antiferromagnet Ba3Yb2Zn5O11. The observed dispersionless excitations are explained by a crystalline electric field (CEF) Hamiltonian of Kramers ion Yb3+ of which the local symmetry exhibits C3v point group symmetry. The magnetic susceptibility previously reported is consistently reproduced by the energy scheme of the CEF excitations. The obtained wave functions of the ground state Kramers doublet exhibit the planer-type anisotropy. The result demonstrates that Ba3Yb2Zn5O11 is an experimental realization of breathing pyrochlore antiferromagnet with a pseudospin S = 1/2 having easy-plane anisotropy.
description: 5 pages, 4 figures
Generalist care managers for the treatment of depressed medicaid patients in North Carolina: A pilot study
Creators: name: Gaynes, Bradley
name: Ellis, Alan R
name: Landis, Suzanne E
name: Morrissey, Joseph P.
name: Domino, Marisa
Publisher: name: BioMed Central Ltd
Year: 2007

description: Abstract Background In most states, mental illness costs are an increasing share of Medicaid expenditures. Specialized depression care managers (CM) have consistently demonstrated improvements in patient outcomes relative to usual primary care (UC), but are costly and may not be fully utilized in smaller practices. A generalist care manager (GCM) could manage multiple chronic conditions and be more accepted and cost-effective than the specialist depression CM. We designed a pilot program to demonstrate the feasibility of training/deploying GCMs into primary care settings. Methods We randomized depressed adult Medicaid patients in 2 primary care practices in Western North Carolina to a GCM intervention or to UC. GCMs, already providing services in diabetes and asthma in both study arms, were further trained to provide depression services including self-management, decision support, use of information systems, and care management. The following data were analyzed: baseline, 3- and 6-month Patient Health Questionnaire (PHQ9) scores; baseline and 6-month Short Form (SF) 12 scores; Medicaid claims data; questionnaire on patients' perceptions of treatment; GCM case notes; physician and office staff time study; and physician and office staff focus group discussions. Results Forty-five patients were enrolled, the majority with preexisting depression. Both groups improved; the GCM group did not demonstrate better clinical and functional outcomes than the UC group. Patients in the GCM group were more likely to have prescriptions of correct dosing by chart data. GCMs most often addressed comorbid conditions (36%), then social issues (27%) and appointment reminders (14%). GCMs recorded an average of 46 interactions per patient in the GCM arm. Focus group data demonstrated that physicians valued using GCMs. A time study documented that staff required no more time interacting with GCMs, whereas physicians spent an average of 4 minutes more per week. Conclusion GCMs can be trained in care of depression and other chronic illnesses, are acceptable to practices and patients, and result in physicians prescribing guideline concordant care. GCMs appear to be a feasible intervention for community medical practices and to warrant a larger scale trial to test their appropriateness for Medicaid programs nationally.
A Model of the Stochastic Gravitational-Wave Background due to Core Collapse to Black Holes
Creators: name: Crocker, K.
name: Mandic, V.
name: Regimbau, T.
name: Belczynski, K.
name: Gladysz, W.
name: Olive, K.
name: Prestegard, T.
name: Vangioni, E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Superposition of gravitational waves generated by astrophysical sources is expected to give rise to the stochastic gravitational-wave background. We focus on the background generated by the ring-down of black holes produced in the stellar core collapse events across the universe. We systematically study the parameter space in this model, including the most recent information about the star formation rate and about the population of black holes as a function of redshift and of metallicity. We investigate the accessibility of this gravitational wave background to the upcoming gravitational-wave detectors, such as Advanced LIGO and Einstein Telescope.
Polyharmonic Maass forms for PSL(2, Z)
Creators: name: Lagarias, Jeffrey C.
name: Rhoades, Robert C.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Analysis of PDEs (math.AP)
subject: Number Theory (math.NT)
subject: FOS: Mathematics

description: We discuss polyharmonic Maass forms of even integer weight on PSL(2, Z)\H, which are a generalization of classical Maass forms. We explain the role of real-analytic Eisenstein series E_k(z, s) and the differential operator $\partial/\partial s$ in this theory.
description: 36 pages
The method used to analyse claims such as the Generalised Tipping Curve of the SIM pulling tests, the SIM wind load analysis and Visual Tree Assessment
Creators: name: Sterken, Peter
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Plant Sciences
subject: Biological and Chemical Physics
subject: Mechanical Engineering
subject: FOS: Mechanical engineering
subject: Physical Sciences and Mathematics
subject: Agriculture
subject: Life Sciences
subject: Environmental Sciences
subject: Biology
subject: Biomechanical Engineering
subject: Mathematics
subject: FOS: Mathematics
subject: Physics
subject: Forest Sciences
subject: Engineering

description: Current methods such as the Visual Tree Assessment (VTA) of Mattheck and the pulling tests of Wessolly (SIM) and others will be analysed here. It will be shown that the published “Generalised Tipping Curve” (GTC), which purportedly predicts the uprooting of trees based on empirical data, is suggestive of misinformation. Entirely different SIM and other curves were found that had already been in use since at least 1983 by comparatively unknown authors and 2003 (SIM curve) until now. This paper also analyses highly-cited and influential proclamations regarding the GTC and the “dynamic” versus “quasi-static” WLA, that may have, quite simply, sprouted from unconscious research bias.
On Secure Network Coding for Two Unicast Sessions
Creators: name: Agarwal, Gaurav Kumar
name: Cardone, Martina
name: Fragouli, Christina
Publisher: name: arXiv
Year: 2016
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: This paper characterizes the secret message capacity of three networks where two unicast sessions share some of the communication resources. Each network consists of erasure channels with state feedback. A passive eavesdropper is assumed to wiretap any one of the links. The capacity achieving schemes as well as the outer bounds are formulated as linear programs. The proposed strategies are then numerically evaluated and shown to achieve higher rate performances (up to a double single- or sum-rate) with respect to alternative strategies, where the network resources are time-shared among the two sessions. These results represent a step towards the secure capacity characterization for general networks. They also show that, even in configurations for which network coding does not offer benefits in absence of security, it can become beneficial under security constraints.
description: Parts of this work were accepted for publication at ISIT 2016
Surveillance for sulfadoxine-pyrimethamine resistant malaria parasites in the Lake and Southern Zones, Tanzania, using pooling and next-generation sequencing
Creators: name: Willilo, Ritha A
name: Doctor, Stephanie M
name: Munishi, Oresto M
name: Ngondi, Jeremiah M
name: Paxton, Lynn A
name: Bailey, Jeffrey A
name: Keeler, Corinna
name: Meshnick, Steven R.
name: Mkude, Sigsbert
name: Gutman, Julie
name: Lalji, Shabbir
name: Hathaway, Nicholas J
name: Kitojo, Chonge
name: Thwai, Kyaw L
name: Kaspar, Naomi
name: Ishengoma, Deus S
name: Juliano, Jonathan
Publisher: name: BioMed Central
Year: 2017

description: Abstract Background Malaria in pregnancy (MiP) remains a major public health challenge in areas of high malaria transmission. Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) is recommended to prevent the adverse consequences of MiP. The effectiveness of SP for IPTp may be reduced in areas where the dhps581 mutation (a key marker of high level SP resistance) is found; this mutation was previously reported to be common in the Tanga Region of northern Tanzania, but there are limited data from other areas. The frequency of molecular markers of SP resistance was investigated in malaria parasites from febrile patients at health centres (HC) in seven regions comprising the Lake and Southern Zones of mainland Tanzania as part of the ongoing efforts to generate national-wide data of SP resistance. Methods A cross-sectional survey was conducted in the outpatient departments of 14 HCs in seven regions from April to June, 2015. 1750 dried blood spot (DBS) samples were collected (117 to 160 per facility) from consenting patients with positive rapid diagnostic tests for malaria, and no recent (within past 2 months) exposure to SP or related drugs. DNA was extracted from the DBS, pooled by HC, and underwent pooled targeted amplicon deep sequencing to yield estimates of mutated parasite allele frequency at each locus of interest. Results The dhps540 mutation was common across all 14 sites, ranging from 55 to 98.4% of sequences obtained. Frequency of the dhps581 mutation ranged from 0 to 2.4%, except at Kayanga HC (Kagera Region, Lake Zone) where 24.9% of sequences obtained were mutated. The dhfr164 mutation was detected only at Kanyanga HC (0.06%). Conclusion By pooling DNA extracts, the allele frequency of mutations in 14 sites could be directly determined on a single deep-sequencing run. The dhps540 mutant was very common at all locations. Surprisingly, the dhps581 was common at one health center, but rare in all the others, suggesting that there is geographic micro-heterogeneity in mutant distribution and that accurate surveillance requires inclusion of multiple sites. A better understanding of the effect of the dhps581 mutant on the efficacy of IPTp-SP is needed.
Supplementary materials for the Data Protection Record of Processing Activities and Privacy Notice generator toolkit by EMBL’s European Bioinformatics Institute
Creators: name: Gonzalez-Ferreiro, Montserrat
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Business
subject: Engineering
subject: Law
subject: FOS: Law
subject: data protection
subject: GDPR
subject: intergovernmental organisation
subject: personal data
subject: privacy notice
subject: record of processing activities
subject: research infrastructures

description: Templates for the Data Protection Record of Processing Activities and Privacy Notice generator toolkit by EMBL’s European Bioinformatics Institute.
Improved representation of cattle herd dynamics for bio-physical modelling of pathways to a climate neutral land sector
Creators: name: Henn, Daniel
name: Humphreys, James
name: Duffy, Colm
name: Gibbons, James
name: Styles, David
Publisher: name: University of Limerick
Year: 2023
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences

description: CONTEXT: Livestock production contributes to food security and livelihood improvement globally but places a significant burden on the environment. In Ireland, an ongoing transition towards highly profitable dairy production after the phasing out of EU milk quotas has changed the composition of the national cattle herd with more dairy and fewer beef cows. This shift impacts greenhouse gas (GHG) accounting across different cattle cohorts, e.g. increasing the proportion of calves from the dairy herd. Dairy x beef crossbreeds (DxB) increasingly contribute to national beef output, leveraging larger average daily liveweight gain (ADG) traits from beef breeding bulls. OBJECTIVE: Prospective modelling of climate and land consequences arising from alternative cattle production strategies requires more accurate simulation of cohort-specific ADG and associated feed requirements and GHG emissions.METHODS: A new COHORTS model was developed to improve national climate scenario mitigation modelling.COHORTS is capable of simulating 21 genetics-gender-age cohorts calibrated to Irish performance, using just a few basic input parameters (at minimum dairy- and beef-cow numbers). A cohort specific ADG and average standing liveweight is estimated for each genetic (pure dairy calves, DxB and pure beef calves), gender and age combination, enabling more accurate calculation of energy requirements and enteric fermentation emissions based on IPCC Tier 2 calculations.RESULTS AND CONCLUSIONS: National simulation of cattle numbers, enteric fermentation emissions and beef outputs were validated against relevant Irish inventories. For the period between 2006 and 2020, simulations resulted in total cattle numbers, emissions and beef production within 4%, 1.8% and 0.5%, respectively, of officially reported data. Our results indicate that climate projections based on average emission factors for preadult cattle cohorts may overestimate emissions in scenarios with projected growing dairy calf numbers and declining beef calf numbers. SIGNIFICANCE: Validation using a 15-year data time series provides a high degree of confidence that COHORTS can be used to represent future herd dynamics in a wide range of scenarios, supporting robust policy regarding GHG mitigation, livestock production and land use – distinguishing between different levels of dairy or beef specialisation and across different levels of performance to predict forage (land) requirements and GHG emissions more accurately. COHORTS can be easily adapted for other countries, even when limited data are available.
Prevalence of preterm, low birthweight, and small for gestational age delivery after breast cancer diagnosis: a population-based study
Creators: name: Eng, Eugenia
name: Nichols, Hazel
name: Rowley, Diane
name: Black, Kristin Z
Publisher: name: BioMed Central
Year: 2017

description: Abstract Background Black-white disparities in breast cancer incidence rates and birth outcomes raise concerns about potential disparities in the reproductive health of premenopausal breast cancer survivors. We examined the prevalence of preterm birth (PTB), low birthweight (LBW), and small for gestational age (SGA) by breast cancer history and effect modification by race. Methods We analyzed linked North Carolina birth records and Central Cancer Registry files from 1990 to 2009 (n = 2,325,229). We used multivariable negative log-binomial regression to calculate prevalence ratios (PRs) and 95% confidence intervals (CIs) for the association between breast cancer history and PTB, LBW, and SGA. Results Of 1,912,269 eligible births, 512 births were to mothers with a previous breast cancer diagnosis history. Average age at breast cancer diagnosis was 31.8 years (SD = 4.7). Mean time from diagnosis to delivery was 3.3 years (SD = 2.8). After multivariable adjustment, the PR was 1.67 (95% CI, 1.42–1.97) for PTB, 1.50 (95% CI, 1.23–1.84) for LBW, and 1.30 (95% CI, 1.05–1.61) for SGA comparing women with a breast cancer history to the general population. Among black mothers, the PRs associated with breast cancer history for PTB, LBW, and SGA were 1.31 (95% CI, 1.00–1.72), 1.49 (95% CI, 1.14–1.94), and 1.44 (95% CI, 1.11–1.87), respectively. The corresponding PRs among white mothers were 2.06 (95% CI, 1.67–2.54), 1.53 (95% CI, 1.12–2.08), and 1.10 (95% CI, 0.77–1.58), respectively. The interaction between breast cancer history and race was statistically significant for associations with PTB, but not for LBW or SGA. Conclusions In our data, women with a breast cancer history were at higher risk of delivering a PTB, LBW, or SGA infant, especially if they received chemotherapy or gave birth within 2 years of their breast cancer diagnosis date.
Finite-temperature buckling of an extensible rod
Creators: name: Bedi, Deshpreet Singh
name: Mao, Xiaoming
Publisher: name: arXiv
Year: 2015
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Thermal fluctuations can play an important role in the buckling of elastic objects at small scales, such as polymers or nanotubes. In this paper, we study the finite-temperature buckling transition of an extensible rod by analyzing fluctuation corrections to the elasticity of the rod. We find that, in both two and three dimensions, thermal fluctuations delay the buckling transition, and near the transition, there is a critical regime in which fluctuations are prominent and make a contribution to the effective force that is of order $\sqrt{T}$. We verify our theoretical prediction of the phase diagram with Monte Carlo simulations.
description: 14 pages, 5 figures
Assessing Competence in Chest Tube Insertion with the ACTION-tool: a Delphi study
Creators: name: De Mol, Leander
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medical Sciences
subject: Medicine and Health Sciences
subject: Medical Education
subject: Assessment
subject: Chest Tube Insertion
subject: Delphi Study
subject: Error checklist
subject: Rating Scale

description: This study aimed to develop a novel assessment tool for CTI and to ensure content validity based on expert opinion collected through a structured Delphi study.
Circumventing Heisenberg's uncertainty principle in atom interferometry tests of the equivalence principle
Creators: name: Roura, Albert
Publisher: name: arXiv
Year: 2015
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Atom interferometry tests of universality of free fall based on the differential measurement of two different atomic species provide a useful complement to those based on macroscopic masses. However, when striving for the highest possible sensitivities, gravity gradients pose a serious challenge. Indeed, the relative initial position and velocity for the two species need to be controlled with extremely high accuracy, which can be rather demanding in practice and whose verification may require rather long integration times. Furthermore, in highly sensitive configurations gravity gradients lead to a drastic loss of contrast. These difficulties can be mitigated by employing wave packets with narrower position and momentum widths, but this is ultimately limited by Heisenberg's uncertainty principle. We present a novel scheme that simultaneously overcomes the loss of contrast and the initial co-location problem. In doing so, it circumvents the fundamental limitations due to Heisenberg's uncertainty principle and eases the experimental realization by relaxing the requirements on initial co-location by several orders of magnitude.
description: 7 pages + 5 pages of Supplemental Material including a summary of the formalism developed in arXiv:1401.7699 for completeness
Neural network checkpoints
Creators: name: Atapour-Abarghouei, Amir
name: Breckon, Toby P.
Publisher: name: Durham University
Year: 2018
Subjects: subject: Vision, Monocular
subject: Image processing
subject: Computer vision
subject: Image processing
subject: Monocular depth estimation
subject: Image style transfer
subject: Domain adaptation

description: Neural network checkpoints associated with the work entitled: Real-time monocular depth estimation using synthetic data with domain adaptation via image style transfer / written by A. Atapour-Abarghouei and T.P. Breckon. -- In: IEEE Computer Society Conference on Computer Vision and Pattern Recognition (2018 : Salt Lake City, Utah).
description: The files are to be used with the code at https://github.com/atapour/styleDepth-Inference
Congestion Control for P2P Live Streaming
Creators: name: Efthymiopoulos, Nikolaos
name: Christakidis, Athanasios
name: Efthymiopoulou, Maria
name: Corazza, Loris
name: Denazis, Spyros
Publisher: name: arXiv
Year: 2015
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: Multimedia (cs.MM)
subject: FOS: Computer and information sciences

description: In recent years, research efforts tried to exploit peer-to-peer (P2P) systems in order to provide Live Streaming (LS) and Video-on-Demand (VoD) services. Most of these research efforts focus on the development of distributed P2P block schedulers for content exchange among the participating peers and on the characteristics of the overlay graph (P2P overlay) that interconnects the set of these peers. Currently, researchers try to combine peer-to-peer systems with cloud infrastructures. They developed monitoring and control architectures that use resources from the cloud in order to enhance QoS and achieve an attractive trade-off between stability and low cost operation. However, there is a lack of research effort on the congestion control of these systems and the existing congestion control architectures are not suitable for P2P live streaming traffic (small sequential non persistent traffic towards multiple network locations). This paper proposes a P2P live streaming traffic aware congestion control protocol that: i) is capable to manage sequential traffic heading to multiple network destinations , ii) efficiently exploits the available bandwidth, iii) accurately measures the idle peer resources, iv) avoids network congestion, and v) is friendly to traditional TCP generated traffic. The proposed P2P congestion control has been implemented, tested and evaluated through a series of real experiments powered across the BonFIRE infrastructure.
description: 21 pages
Functional validation of novel compound heterozygous variants in B3GAT3 resulting in severe osteopenia and fractures: expanding the disease phenotype
Creators: name: Couser, Natario
name: Smith, Laurie
Publisher: name: BioMed Central
Year: 2016

description: Abstract Background A new disease class of syndromes, described as linkeropathies, which are derived from defects in the glycosaminoglycan-linker region as well as glycosaminoglycan-side chains of proteoglycans is increasingly being recognized as a cause of human disease. Proteoglycans are an essential component of the extracellular matrix. Defects in the enzymatic process of proteoglycan synthesis broadly occur due to the incorrect addition of side chains. Previously, homozygous missense variants within the B3GAT3 gene encoding beta 1,3 glucuronyltransferase 3(GlcAT-I) responsible for the biosynthesis of glycosaminoglycans have been described in 7 individuals. Case presentation In this study, a 4-year-old patient with a severe phenotype of osteoporosis, hypotonia, joint laxity, fractures, scoliosis, biscuspid aortic valve and myopia was referred for next generation sequencing after extensive negative clinical testing. Whole exome sequencing was performed on the proband and his unaffected parents to identify the molecular basis of his disease. Sequencing revealed compound heterozygous variants in B3GAT3: c.1A > G (p.Met1?) and c.671 T > A (p.L224Q). Clinical and in vitro functional studies were then completed to verify the pathogenicity of the genotype and further characterize the functional basis of the patient’s disease demonstrating the patient had a decrease both in the protein level of B3GAT3 and in the glucuronyltransferase activity when compared to control samples. Independent in vitro assessment of each variant confirmed the B3GAT3: c.1A > G (p.Met1?) variant is functionally null and the c.671 T > A (p.L224Q) missense variant has significantly reduced glucuronyltransferase activity (~3% of control). Conclusions This is the first report of a patient with compound heterozygosity for a null variant in trans with a missense in B3GAT3 resulting in a severe phenotype, expanding both the genotypic and phenotypic spectrum of B3GAT3-related disease.