cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Lumbar spine segmentation in MR images: a dataset and a public benchmark
Creators: name: van der Graaf, Jasper W.
name: van Hooff, Miranda L.
name: Buckens, Constantinus F. M.
name: Rutten, Matthieu
name: van Susante, Job L. C.
name: Kroeze, Robert Jan
name: de Kleuver, Marinus
name: van Ginneken, Bram
name: Lessmann, Nikolas
Publisher: name: arXiv
Year: 2023
Subjects: subject: Image and Video Processing (eess.IV)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: FOS: Computer and information sciences

description: This paper presents a large publicly available multi-center lumbar spine magnetic resonance imaging (MRI) dataset with reference segmentations of vertebrae, intervertebral discs (IVDs), and spinal canal. The dataset includes 447 sagittal T1 and T2 MRI series from 218 patients with a history of low back pain and was collected from four different hospitals. An iterative data annotation approach was used by training a segmentation algorithm on a small part of the dataset, enabling semi-automatic segmentation of the remaining images. The algorithm provided an initial segmentation, which was subsequently reviewed, manually corrected, and added to the training data. We provide reference performance values for this baseline algorithm and nnU-Net, which performed comparably. Performance values were computed on a sequestered set of 39 studies with 97 series, which were additionally used to set up a continuous segmentation challenge that allows for a fair comparison of different segmentation algorithms. This study may encourage wider collaboration in the field of spine segmentation and improve the diagnostic value of lumbar spine MRI.
description: Published in Scientific Data
Robust Parameter Design With Computer Experiments Using Orthonormal Polynomials
Creators: name: Tan, Matthias Hwai Yong
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Cancer
subject: Mathematics
subject: FOS: Mathematics
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Earth and Environmental Sciences
subject: Neuroscience
subject: Genetics

description: Robust parameter design with computer experiments is becoming increasingly important for product design. Existing methodologies for this problem are mostly for finding optimal control factor settings. However, in some cases, the objective of the experimenter may be to understand how the noise and control factors contribute to variation in the response. The functional analysis of variance (ANOVA) and variance decompositions of the response, in addition to the mean and variance models, help achieve this objective. Estimation of these quantities is not easy and few methods are able to quantity the estimation uncertainty. In this article, we show that the use of an orthonormal polynomial model of the simulator leads to simple formulas for functional ANOVA and variance decompositions, and the mean and variance models. We show that estimation uncertainty can be taken into account in a simple way by first fitting a Gaussian process model to experiment data and then approximating it with the orthonormal polynomial model. This leads to a joint normal distribution for the polynomial coefficients that quantifies estimation uncertainty. Supplementary materials for this article are available online.
Additional file 1 of CRISPR base editing-mediated correction of a tau mutation rescues cognitive decline in a mouse model of tauopathy
Creators: name: Gee, Min Sung
name: Kwon, Eunji
name: Song, Myeong-Hoon
name: Jeon, Seung Ho
name: Kim, Namkwon
name: Lee, Jong Kil
name: Koo, Taeyoung
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Neuroscience
subject: Evolutionary Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Mental Health
subject: Computational Biology

description: Additional file 1: Fig. S1. Adenine base editing frequencies induced by NG-ABE8e. Fig. S2. Intracranial delivery of tsAAV-NG-ABE8e into the hippocampus of PS19 mice. Fig. S3. RNA trans-splicing AAV encoding NG-ABE8e for targeted adenine base editing. Fig. S4. Genome-wide specificity of NG-ABE8e. Fig. S5. Representative image of immunoblot using anti-tau antibody between different lysis fractions. Fig. S6. Tau protein levels in soluble fraction of hippocampus. Fig. S7. Representative images and quantification of phospho-tau (AT8) staining of the mouse hippocampus. Fig. S8. The level of MAPT gene expression and gliosis. Fig. S9. Results from the Probe test of Morris water maze. Table S1. The sgRNA target sequences in this study. Table S2. List of primers used for targeted deep sequencing. Table S3. Potential off-target sites of NG-ABE8e targeted to MAPT or Rosa26 identified by Cas-OFFinder. Table S4. Information of antibodies used in this study. Materials and Methods.
Candidate Tear-Based Uveitis Biomarkers in Children with JIA Based on Arthritis Activity and Topical Corticosteroid Use
Creators: name: Maccora, Ilaria
name: Altaye, Mekibib
name: Greis, Kenneth D.
name: Brunner, Hermine I.
name: Duell, Alexandra
name: Haffey, Wendy D.
name: Nguyen, Tiffany
name: Quinlan-Waters, Megan
name: Schulert, Grant S.
name: Sproles, Alyssa
name: Utz, Virginia Miraldi
name: Thornton, Sherry
name: Angeles-Han, Sheila T.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology

description: Uveitis is an inflammatory ocular disease secondary to disruption of the retinal pigmented epithelium (RPE) and blood retinal barrier (BRB). Known clinical factors do not accurately predict uveitis risk in Juvenile Idiopathic Arthritis (JIA). Tear fluid is easily obtained for biomarker study. We aim to identify tear-based markers associated with the presence of uveitis in children with JIA. In a cross-sectional comparative cohort study, tears were collected by Schirmer strips from children with oligoarticular JIA-associated uveitis (JIA-U) and JIA without uveitis (JIA-no-U). A tandem isotope tagging (iTRAQ and TMT) strategy was used for relative quantitation via nanoLC-MS/MS to quantify proteins in the affected eye. Log transformed relative protein abundance of protein levels was compared between groups using Wilcoxon exact test. We explored the influence of arthritis activity and topical corticosteroids (CS) use on protein levels. STRING analysis was performed. Tear samples of 14 JIA-U and 14 JIA-no-U patients were analyzed. Thirteen proteins were differentially expressed between both groups. Stratified analysis based on arthritis activity (inactive arthritis) and topical CS (off CS) showed that alpha-2-macroglobulin (p = 0.012), apolipoprotein A1 (p = 0.036), S100A9 (p = 0.05), haptoglobin (p = 0.066), and transthyretin (p = 0.066) consistently differentiated between both groups. On STRING analysis, these proteins were associated with the RPE, BRB, and inflammation. Importantly, we identified proteins involved in the RPE, BRB, and immune response that were differentially abundant in the tears of children with JIA-U compared to JIA-no-U, regardless of arthritis activity or topical CS. Candidate tear-based biomarkers may represent a non-invasive means to detect uveitis. Question: Is it possible to identify tear-based biomarkers able to identify patients with uveitis in children with Juvenile Idiopathic Arthritis (JIA)? Findings: We identified proteins involved in the immune response and in the retinal barrier that were differentially abundant in the tears of children with JIA-Uveitis compared to JIA-no-Uveitis. Meaning: Tears may be a suitable sample to identify children with JIA with and without uveitis in a non-invasive and objective way.
Ultrafast electro-optic Time-Frequency Fractional Fourier Imaging at the Single-Photon Level
Creators: name: Lipka, Michał
name: Parniak, Michał
Publisher: name: arXiv
Year: 2023
Subjects: subject: Optics (physics.optics)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The Fractional Fourier Transform (FRT) corresponds to an arbitrary-angle rotation in the phase space, e.g. the time-frequency (TF) space, and generalizes the fundamentally important Fourier Transform. FRT applications range from classical signal processing (e.g. time-correlated noise optimal filtering) to emerging quantum technologies (e.g. super-resolution TF imaging) which rely on or benefit from coherent low-noise TF operations. Here a versatile low-noise single-photon-compatible implementation of the FRT is presented. Optical TF FRT can be synthesized as a series of a spectral disperser, a time-lens, and another spectral disperser. Relying on the state-of-the-art electro-optic modulators (EOM) for the time-lens, our method avoids added noise inherent to the alternatives based on non-linear interactions (such as wave-mixing, cross-phase modulation, or parametric processes). Precise control of the EOM-driving radio-frequency signal enables fast all-electronic control of the FRT angle. In the experiment, we demonstrate FRT angles of up to 1.63 rad for pairs of coherent temporally separated 11.5 ps-wide pulses in the near-infrared (800 nm). We observe a good agreement between the simulated and measured output spectra in the bright-light and single-photon-level regimes, and for a range of pulse separations (20 ps to 26.67 ps). Furthermore, a tradeoff is established between the maximal FRT angle and bandwidth, with the current setup accommodating up to 248 GHz of bandwidth. With the ongoing progress in EOM on-chip integration, we envisage excellent scalability and vast applications in all-optical TF processing both in the classical and quantum regimes.
description: 15 pages, 6 figures
Stair Climbing using the Angular Momentum Linear Inverted Pendulum Model and Model Predictive Control
Creators: name: Dosunmu-Ogunbi, Oluwami
name: Shrivastava, Aayushi
name: Gibson, Grant
name: Grizzle, Jessy W
Publisher: name: arXiv
Year: 2023
Subjects: subject: Robotics (cs.RO)
subject: Systems and Control (eess.SY)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: A new control paradigm using angular momentum and foot placement as state variables in the linear inverted pendulum model has expanded the realm of possibilities for the control of bipedal robots. This new paradigm, known as the ALIP model, has shown effectiveness in cases where a robot's center of mass height can be assumed to be constant or near constant as well as in cases where there are no non-kinematic restrictions on foot placement. Walking up and down stairs violates both of these assumptions, where center of mass height varies significantly within a step and the geometry of the stairs restrict the effectiveness of foot placement. In this paper, we explore a variation of the ALIP model that allows the length of the virtual pendulum formed by the robot's stance foot and center of mass to follow smooth trajectories during a step. We couple this model with a control strategy constructed from a novel combination of virtual constraint-based control and a model predictive control algorithm to stabilize a stair climbing gait that does not soley rely on foot placement. Simulations on a 20-degree of freedom model of the Cassie biped in the SimMechanics simulation environment show that the controller is able to achieve periodic gait.
Inability of linear axion holographic Gubser-Rocha model to capture all the transport anomalies of strange metals
Creators: name: Ahn, Yongjun
name: Baggioli, Matteo
name: Jeong, Hyun-Sik
name: Kim, Keun-Young
Publisher: name: arXiv
Year: 2023
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In the last decade, motivated by the concept of Planckian relaxation and the possible existence of a quantum critical point in cuprate materials, holographic techniques have been extensively used to tackle the problem of strange metals and high-$T_c$ superconductors. Among the various setups, the linear axion Gubser-Rocha model has often been considered as a promising holographic model for strange metals since endowed with the famous linear in $T$ resistivity property. As fiercely advocated by Phil Anderson, beyond $T$-linear resistivity, there are several additional anomalies unique to the strange metal phase, as for example a Fermi liquid like Hall angle -- the famous problem of the two relaxation scales. In this short note, we show that the linear axion holographic Gubser-Rocha model, which presents a single momentum relaxation time, fails in this respect and therefore is not able to capture the transport phenomenology of strange metals. We prove our statement by means of a direct numerical computation, a previously demonstrated scaling analysis and also a hydrodynamic argument. Finally, we conclude with an optimistic discussion on the possible improvements and generalizations which could lead to a holographic model for strange metals in all their glory.
description: v2: minor revisions, matching the published version
Diffusion Policies for Out-of-Distribution Generalization in Offline Reinforcement Learning
Creators: name: Ada, Suzan Ece
name: Oztop, Erhan
name: Ugur, Emre
Publisher: name: arXiv
Year: 2023
Subjects: subject: Machine Learning (cs.LG)
subject: Artificial Intelligence (cs.AI)
subject: Neural and Evolutionary Computing (cs.NE)
subject: Robotics (cs.RO)
subject: FOS: Computer and information sciences

description: Offline Reinforcement Learning (RL) methods leverage previous experiences to learn better policies than the behavior policy used for data collection. In contrast to behavior cloning, which assumes the data is collected from expert demonstrations, offline RL can work with non-expert data and multimodal behavior policies. However, offline RL algorithms face challenges in handling distribution shifts and effectively representing policies due to the lack of online interaction during training. Prior work on offline RL uses conditional diffusion models to represent multimodal behavior in the dataset. Nevertheless, these methods are not tailored toward alleviating the out-of-distribution state generalization. We introduce a novel method named State Reconstruction for Diffusion Policies (SRDP), incorporating state reconstruction feature learning in the recent class of diffusion policies to address the out-of-distribution generalization problem. State reconstruction loss promotes generalizable representation learning of states to alleviate the distribution shift incurred by the out-of-distribution (OOD) states. We design a novel 2D Multimodal Contextual Bandit environment to illustrate the OOD generalization and faster convergence of SRDP compared to prior algorithms. In addition, we assess the performance of our model on D4RL continuous control benchmarks, namely the navigation of an 8-DoF ant and forward locomotion of half-cheetah, hopper, and walker2d, achieving state-of-the-art results.
description: 8 pages, 7 figures
Long-Term Outcomes of Pediatric Pars Planitis: Retrospective Cohort from a Single Tertiary Center in Turkey
Creators: name: Çebi, Aslıhan Yılmaz
name: Kılıçarslan, Oğuzhan
name: Uçar, Didar
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Science Policy

description: To retrospectively analyze long-term outcomes of pediatric pars planitis (PP). PP was defined as vitreal inflammation with snowbank or snowball formation in the absence of a related disease. Eighty-five eyes of 44 patients were included in this study. Demographic and clinical characteristics were obtained from medical records. Approximately 70% of the patients were males; the mean patient age was 10.4 ± 3.6 years at presentation, and the mean follow-up time was 42.8 ± 27.9 months. At presentation, the mean best corrected visual acuity (BCVA, logMAR) was 0.17 ± 0.27 in the right eyes and 0.27 ± 0.33 in the left eyes. Common symptoms included blurry vision (29 eyes, 65%), redness (17, 38%), pain (8, 18%), and floaters (5, 11%). Sight-threatening complications included optic disc edema/hyperemia (26, 30%), cataracts (16, 18%), macular edema (16, 18%), and glaucoma (15, 17%). All 38 patients who initially required systemic treatment received corticosteroids. During the follow-up, 24 patients were treated with azathioprine, 20 with methotrexate, 11 with cyclosporine, 20 with adalimumab, and 8 with infliximab. At the final examination, the mean BCVA of the right and left eyes improved significantly (0.08 ± 0.23 and 0.06 ± 0.17, p = 0.006 and p < 0.001, respectively). The severities of vitritis, anterior chamber inflammation, snowbank/snowball formation, and endotheliitis decreased (all p < 0.001). Thirty-one patients remained on systemic treatment, with only four patients still receiving corticosteroids. No life-threatening adverse effects were reported. Despite pediatric PP’s mild course, severe vision-threatening complications can occur. Immunomodulatory or biologic agents are important for controlling inflammation and tapering corticosteroids. Further research could enhance understanding of optimal treatments.
Use of In Vivo and In Vitro Data to Derive a Chronic Reference Value for Crotonaldehyde Based on Relative Potency to Acrolein
Creators: name: Grant, Roberta L.
name: Jenkins, Allison F.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Pharmacology
subject: Cell Biology
subject: Microbiology
subject: Engineering
subject: Biochemistry

description: The Texas Commission on Environmental Quality (TCEQ) conducted a chronic inhalation noncancer toxicity assessment for crotonaldehyde (CRO). Since there were limited toxicity data for CRO, a reference value (ReV) was derived using a relative potency factor (RPF) approach with acrolein as the index chemical. Both CRO and acrolein are α,β-unsaturated carbonyls and share common steps in their mode of action (MOA). Only studies that investigated the effects of CRO and acrolein in the same study were used to calculate a CRO:acrolein RPF. In vivo findings measuring both 50% respiratory depression in rats and two species of mice and subcutaneous 50% lethality in rats and mice were used to calculate an RPF of 3 (rounded to one significant figure). In vitro data were useful to compare the MOA of CRO and acrolein and to support the RPF determined using in vivo data. In vitro cell culture studies investigating cytotoxicity in normal human lung fibroblast cultures using the propidium iodide cytotoxicity assay and in mouse lymphocyte cultures using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cytotoxicity assay were used to calculate an in vitro RPF of 3, which supports the in vivo RPF. The chronic ReV for acrolein of 1.2 ppb derived by TCEQ was multiplied by the RPF of 3 to calculate the ReV for CRO of 3.6 ppb (10 μg/m3). The ReV for CRO was developed to protect the general public from adverse health effects from chronic exposure to CRO in ambient air.
Approximate and ensemble local entanglement transformations for multipartite states
Creators: name: Gunn, David
name: Hebenstreit, Martin
name: Spee, Cornelia
name: de Vicente, Julio I.
name: Kraus, Barbara
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Understanding multipartite entanglement is a key goal in quantum information. Entanglement in pure states can be characterised by considering transformations under Local Operations assisted by Classical Communication (LOCC). However, it has been shown that, for $n\ge5$ parties, multipartite pure states are generically isolated, i.e., they can neither be reached nor transformed under LOCC. Nonetheless, in any real lab, one never deterministically transforms a pure initial state exactly to a pure target state. Instead, one transforms a mixed state near the initial state to an ensemble that is on average close to the target state. This motivates studying approximate LOCC transformations. After reviewing in detail the known results in the bipartite case, we present the gaps that remain open in the multipartite case. While the analysis of the multipartite setting is much more technically involved due to the existence of different SLOCC classes, certain features simplify in the approximate setting. In particular, we show that it is sufficient to consider pure initial states, that it is sufficient to consider LOCC protocols with finitely-many rounds of communication and that approximate transformations can be approximated by ensemble transformations within an SLOCC class. Then, we formally define a hierarchy of different forms of approximate transformations that are relevant from a physical point of view. Whereas this hierarchy collapses in the bipartite case, we show that this is not the case for the multipartite setting, which is fundamentally richer. To wit, we show that optimal multipartite approximate transformations are not generally deterministic, that ensemble transformations within an SLOCC class can achieve a higher fidelity than deterministic transformations within an SLOCC class, and that there are approximate transformations with no deterministic transformations nearby.
description: 23 pages, 6 figures
Easy Conversion of Dimethyl α-(Bromomethyl)fumarate into Functionalized Allyl Ethers Mediated by DABCO
Creators: name: Aïcha Arfaoui
name: Saâdi, Fatma
name: Nefzi, Adel
name: Hassen Amri
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 60506 Virology
subject: FOS: Biological sciences
subject: Science Policy
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Molecular Biology
subject: Cell Biology
subject: Biochemistry

description: New functionalized allyl ethers were obtained in good yields following the mild selective reaction of different alcohols with allyl bromide in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO) and a catalytic amount of triethylamine (TEA) at room temperature.
Epidemiology of Intermediate Uveitis
Creators: name: Besagar, Sonya
name: de-la-Torre, Alejandra
name: Thorne, Jennifer
name: Biswas, Jyotirmay
name: Agrawal, Rupesh
name: Suhler, Eric B.
name: Kempen, John H.
name: Gangaputra, Sapna
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Medicine
subject: Neuroscience
subject: Ecology
subject: FOS: Biological sciences
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Intermediate uveitis is defined as inflammation of the vitreous and pars planitis. Etiology can be infectious, associated with a systemic disease, neoplastic or idiopathic. Pars planitis is the term used for idiopathic intermediate uveitis that presents with snowballs and snowbanks. While relatively rare, intermediate uveitis is present globally and typically affects adult females. Awareness of the presentation and a dilated fundus examination in patients presenting with floaters is essential to the diagnosis. PCR testing has enhanced the ability to diagnose infectious and neoplastic conditions that masquerade as intermediate uveitis. A structured review of systems and focused imaging, and laboratory testing will assist with early diagnosis and initiation of treatment.
DRAGON: A Dialogue-Based Robot for Assistive Navigation with Visual Language Grounding
Creators: name: Liu, Shuijing
name: Hasan, Aamir
name: Hong, Kaiwen
name: Wang, Runxuan
name: Chang, Peixin
name: Mizrachi, Zachary
name: Lin, Justin
name: McPherson, D. Livingston
name: Rogers, Wendy A.
name: Driggs-Campbell, Katherine
Publisher: name: arXiv
Year: 2023
Subjects: subject: Robotics (cs.RO)
subject: Artificial Intelligence (cs.AI)
subject: Computation and Language (cs.CL)
subject: Human-Computer Interaction (cs.HC)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Persons with visual impairments (PwVI) have difficulties understanding and navigating spaces around them. Current wayfinding technologies either focus solely on navigation or provide limited communication about the environment. Motivated by recent advances in visual-language grounding and semantic navigation, we propose DRAGON, a guiding robot powered by a dialogue system and the ability to associate the environment with natural language. By understanding the commands from the user, DRAGON is able to guide the user to the desired landmarks on the map, describe the environment, and answer questions from visual observations. Through effective utilization of dialogue, the robot can ground the user's free-form descriptions to landmarks in the environment, and give the user semantic information through spoken language. We conduct a user study with blindfolded participants in an everyday indoor environment. Our results demonstrate that DRAGON is able to communicate with the user smoothly, provide a good guiding experience, and connect users with their surrounding environment in an intuitive manner. Videos and code are available at https://sites.google.com/view/dragon-wayfinding/home.
description: Published in IEEE Robotics and Automation Letters (RA-L)
A VIOLÊNCIA PATRIMONIAL NA RELAÇÃO DE GÊNERO: DESAFIOS E PERSPECTIVAS DE ENFRENTAMENTO
Creators: name: Nathália Chiang Pereira Freire BARROSO
name: Shara Caroline Conceição de Sousa SILVA
name: Bruna Ribeiro de PAULA
Publisher: name: Zenodo
Year: 2024
Subjects: Violência patrimonial
Gênero
Lei Maria da Penha
Direitos das mulheres
Enfrentamento

description: RESUMO

Este artigo tem como objetivo analisar a violência patrimonial nas relações de gênero, abordando seus desafios e as perspectivas de enfrentamento no contexto brasileiro. A violência patrimonial, caracterizada pela retenção, destruição ou controle dos bens da vítima, é uma das formas menos visíveis de violência contra a mulher, mas com impactos profundos na autonomia e independência financeira. A pesquisa, de caráter bibliográfico e qualitativo, revisa estudos sobre o tema e analisa a legislação vigente, como a Lei Maria da Penha, destacando sua aplicação e eficácia no combate a esse tipo de abuso. Além disso, discute as barreiras que as vítimas enfrentam para denunciar e obter justiça, como a falta de conhecimento sobre seus direitos e a ausência de suporte especializado. A análise revela que, apesar dos avanços legais, a violência patrimonial ainda é subnotificada e subestimada, exigindo ações integradas entre o sistema de justiça, políticas públicas de conscientização e o fortalecimento das redes de apoio. O estudo conclui que, para um enfrentamento eficaz, é necessário ampliar o debate sobre o tema e promover maior capacitação dos profissionais envolvidos, bem como assegurar medidas de proteção e autonomia para as vítimas.
Efficacy and Safety of Fluocinolone Acetonide 0.19 mg Intravitreal Implant for the Treatment of Non-Infectious Uveitis: A Systematic Review of Real-World Evidence
Creators: name: Christensen, Louise Fischer
name: Hassing, Anne Kjærsgaard
name: Klefter, Oliver Niels
name: Vorum, Henrik
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Infectious Diseases
subject: FOS: Health sciences

description: This systematic review evaluates the real-world efficacy and safety of the 0.19 mg fluocinolone acetonide (FAc) sustained-release intravitreal implant for treating non-infectious uveitis affecting the posterior segment of the eye (NIU-PS). Following PRISMA guidelines, a search was conducted in PubMed, Embase and Web of Science, with the latest update on September 20, 2024. Twelve real-world studies involving a total of 382 patients (514 eyes) were included in the review. Compared to baseline, the studies consistently showed reduced mean central retinal thickness for up to 36 months post-FAc implantation, while mean visual acuity was stable or significantly improved. Intraocular inflammation, as per the Standardization of Uveitis Nomenclature grading system, was persistently absent or improved, with evidence extending to 12 months following implantation. While FAc generally showed potential to reduce or maintain systemic immunosuppressive treatments, this effect was not consistently observed, particularly in cases involving choroidal inflammation. Local rescue treatment was used in up to 24% of eyes. Mean intraocular pressure remained stable for 36 months with up to 38.5% of eyes requiring either supplemental or initial IOP-lowering medication. Limited data was available on cataract development. A few cases of hypotony as well as one case of retinal detachment were observed. Overall, current real-world evidence aligns with clinical trial findings, suggesting that the 0.19 mg FAc implant is an effective adjunctive maintenance treatment for NIU-PS with a consistent safety profile. Further studies are needed to refine treatment guidelines.
Writing System v. 1.2 PDF
Creators: name: Baron, Richard
Publisher: name: figshare
Year: 2015
Subjects: Digital Humanities

description: This document sets out a system for writing substantial documents. The system should ensure that everything gets checked and backed up, as well as imposing version control. This is the PDF file. There is also a .tex file on Figshare, which can be downloaded and adapted to individuals' needs.
Writing System v. 1.2 .tex
Creators: name: Baron, Richard
Publisher: name: figshare
Year: 2015
Subjects: Digital Humanities

description: This document sets out a system for writing substantial documents. The system should ensure that everything gets checked and backed up, as well as imposing version control. This is the .tex file, which can be downloaded and adapted to individuals' needs. There is also a PDF version on Figshare.
Guide de Découverte des Phages
Creators: name: Williams, Elizabeth
name: Tremblay, Veronique
name: Dale, Katie
name: Rudner, Adam
Publisher: name: QUBES Educational Resources
Year: 2024

description: La ressource « Guide de Découverte des Phages » est une traduction en français du manuel en ligne Phage Discovery Guide, offrant ainsi une ressource aux enseignants et apprenants dont la langue principale est le français.

The “Guide de Découverte des Phages” resource is a French translation of the online Phage Discovery Guide and provides a resource to instructors and learners whose primary language is French.
Twisted braids
Creators: name: Xue, Shudan
name: Deng, Qingying
Publisher: name: arXiv
Year: 2024
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics

description: Twisted knot theory, introduced by M.O. Bourgoin, is a generalization of virtual knot theory. It naturally yields the notion of a twisted braid, which is closely related to the notion of a virtual braid due to Kauffman. In this paper, we first prove that any twisted link can be described as the closure of a twisted braid, which is unique up to certain basic moves. This is the analogue of the Alexander Theorem and the Markov Theorem for classical braids and links. Then we also give reduced presentations for the twisted braid group and the flat twisted braid group. These reduced presentations are based on the fact that these twisted braid groups on $n$ strands are generated by a single braiding element and a single bar element plus the generators of the symmetric group on $n$ letters.
description: 37 pages, 46 figures
Barriers to Adherence with Immunosuppressive Therapy in Patients with Uveitis
Creators: name: Sun, Karen
name: Marshall, Rayna
name: Frankland, Michael
name: Taylor, Amal
name: Montana, Cynthia
name: Crowell, Eric
name: Armbrust, Karen R.
name: Kopplin, Laura
name: Berkenstock, Meghan
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Pharmacology
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: FOS: Biological sciences
subject: Computational Biology

description: To evaluate the barriers to adherence with immunomodulatory therapy (IMT) for patients with uveitis across multiple regions of the United States. A multi-center survey of adult and pediatric patients with ocular inflammatory diseases undergoing treatment with IMT was conducted between September 2021 and August 2022. Participating sites included Johns Hopkins Wilmer Eye Institute, Wong Eye Institute of the University of Texas at Austin, University of Wisconsin-Madison, University of Minnesota, Veterans Affairs Hospital of Minneapolis, and Washington University of St. Louis. Each patient completed a self-reporting survey to identify barriers to adherence. The survey was completed by 98 subjects, of whom were 71% white, 67% female, and 61% had a college or advanced degree. Nearly half (49%) were on two or more IMTs of which the most common were methotrexate (38%), mycophenolate (36%), or adalimumab (36%). Nearly half (52%) of patients required reminders to take their medications and 20% found it difficult to take IMT regularly, with 12% struggling to take medications multiple times a day. A lack of refills resulted in 15% of patients missing doses. Limitations to completing laboratory studies to monitor for drug-related side-effects included finding time (10%) and cost (22%). Barriers to IMT treatment include laboratory study cost, difficulty with medication administration, and adhering to medication schedules. Monthly cost of medication was high for some, but no patients were unable to take IMT due to insurance loss. Addressing these barriers may improve IMT adherence for uveitis patients and better clinical outcomes.
Patterns and Outcomes of Pediatric Uveitis in a University-Based Tertiary Referral Center in Riyadh, Saudi Arabia
Creators: name: AlBloushi, Abdulrahman F.
name: AlTariqi, Sulaiman M.
name: Alghofaili, Ruba Saleh
name: Gikandi, Priscilla W.
name: Abu El-Asrar, Ahmed M.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: To investigate the patterns and outcomes of pediatric uveitis. Retrospective review of patients with uveitis in pediatric age group. A total of 184 patients (335 eyes) were included. There were 96 (52.2%) boys and 88 (47.8%) girls, with a mean age of 12.8 ± 3.4 years at presentation. Panuveitis was most common (55.2%), followed by anterior uveitis (29.6%), intermediate uveitis (12.2%) and posterior uveitis (3%). Uveitis was non-granulomatous in 71% and non-infectious in 94.6% of the eyes. The most identifiable specific diagnoses were Vogt-Koyanagi-Harada (VKH) disease (21.2%), juvenile idiopathic arthritis (6.5%), sarcoidosis (4.3%), and presumed tuberculous uveitis (3.3%). After 1-year follow-up, 85.4% of the eyes achieved visual acuity of 20/40 or better. The most common anatomic diagnosis was panuveitis. VKH disease was the most frequently diagnosed entity.
Automated Rehabilitation System: Movement Measurement and Feedback for Patients and Physiotherapists in the Rehabilitation Clinic
Creators: name: Lam, Agnes W. K.
name: Danniel Varona-Marin
name: Yeti Li
name: Fergenbaum, Mitchell
name: Kulić, Dana
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: In current physical rehabilitation protocols, patients typically perform exercises with intermittent feedback or guidance following the initial demonstrations from the physiotherapist. Although many patient-centered systems have been developed for home rehabilitation, few systems have been developed to aid the physiotherapist as well as patients in the rehabilitation clinic. This article proposes the Automated Rehabilitation System (ARS), a system designed specifically for rehabilitation clinics using an iterative design process, developed with physiotherapists and patients in a knee and hip replacement clinic. ARS consists of body-worn inertial measurement units that continuously measure the patient’s pose. The measured pose is graphically represented as an animation and overlaid with the instructed motion on a visual display shown to the patient during exercise performance. ARS allows physiotherapists to quantitatively measure patient movement, assess recovery progress, and manage and schedule exercise regimens for patients. The system requirements and design requirements were derived through a focus group with 13 physiotherapists. For patients, ARS provides visual feedback and a novel exercise guidance feature to aid them while exercising. The patient interface was evaluated in a user study with 26 outpatients. The results show that performing the exercises with the visual guidance tool improves the quality of exercise performance.
Serum Vitamin D Levels in Patients with Vernal Keratoconjunctivitis: A Systematic Review and Meta-Analysis
Creators: name: Daneshvar, Kimia
name: Chaibakhsh, Samira
name: Iranpour, Shila
name: Rahmanipour, Elham
name: Ghorbani, Sara
name: Pourazizi, Mohsen
name: Peyman, Alireza
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Medicine
Science Policy
Hematology

description: To conduct a systematic review and meta-analysis to provide an outline of available data on the association between serum vitamin D levels and vernal keratoconjunctivitis (VKC) and to determine the possible relationship in children. Systematic research on all articles published until July 2023 was conducted in PubMed, SCOPUS, Web of Science, and Embase. All observational-analytical studies that measured vitamin D levels in patients with VKC were included. Extracted data were included in two separate meta-analyses: 1) a meta-analysis on the standardized mean difference (SMD) of vitamin D levels between VKC patients and the control group and 2) a meta-analysis on the prevalence of vitamin D deficiency in VKC patients. Seven relevant studies that included 316 patients, with the mean age of 10.8 3 ± 1.14 years, with VKC were included in this meta-analysis. The mean serum vitamin D level was significantly lower in the patients with VKC as compared with the control group (SMD: −0.92; 95% CI −1.15, −0.69, p < 0.001). The overall prevalence of vitamin D deficiency among VKC patients was 63.7% (95% CI 42.5%-80.7%, p < 0.001). VKC patients spent significantly less time outdoors during daylight compared to healthy individuals (SMD = −0.90, 95%CI −1.28, −0.52, p < 0.001). VKC patients have lower serum vitamin D than healthy controls. This finding underscores the potential role of vitamin D in the immunopathogenesis of VKC.
Multimodal Imaging in Unilateral Acute Idiopathic Maculopathy with Staphylococcus aureus Infection
Creators: name: Mahendradas, Padmamalini
name: Patil, Aditya
name: Patil, Rahul
name: Narasimhan, Raghav
name: Sriram, Radhika
name: Mishra, Sai Bhakti
name: Kawali, Ankush
name: Gowda, Poornachandra
name: Shetty, Rohit
name: Roy, Abhijit Sinha
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: Science Policy
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: To report the multimodal imaging findings in the case of unilateral acute idiopathic maculopathy (UAIM) associated with Staphylococcus aureus infection in a young girl with good clinical outcome. Rare case report with multimodal imaging including fundus photography, optical coherence tomography (OCT), autofluorescence, multicolor imaging, OCT angiography, fluorescein angiography (FA), and polarization sensitive OCT (PS-OCT). A 13-year-old girl presented with blurring of vision in the left eye (OS). Fundus examination revealed yellowish subretinal deposits at the fovea in OS with findings resembling UAIM on ophthalmoscopy, OCT, and FA. We noted the OCT angiography and PS-OCT findings in this case. Blood culture revealed the growth of Staphylococcus aureus. Autoimmune work-up was negative. Patient was treated with appropriate systemic antibiotics. At 8 weeks follow-up, there was resolution of the lesion clinically and on OCT, with residual derangement of the retinal pigment epithelium. Our patient had UAIM presumed to have been triggered by systemic bacterial infection. The patient made an uneventful recovery following antimicrobial therapy. Multimodal imaging demonstrates the affection of the outer retinal layers and retinal pigment epithelium in this case.
Poly(acrylic acid)-zeolite nanocomposites for dye removal from single and binary systems
Creators: name: Almasian, Arash
name: Mazeyar Parvinzadeh Gashti
name: Olya, Mohammad Ebrahim
name: Ghazaleh Chizari Fard
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Plant Biology

description: In this research, nanocomposites of zeolite/acrylic acid were synthesized with different amount of acrylic acid (AA) as monomer and ammonium persulfate (APS) as an initiator to remove cationic dyes from wastewater in single and binary systems. Basic Red 46 (BR46) and Basic blue 41 (BB41) were used as the cationic dyes. The surface characteristics of nanocomposites were investigated using Fourier transform infrared spectra (FTIR) and scanning electron microscope. FTIR results confirmed successful attachment of acrylic acid on the zeolite surface. The influence of different factors such as initial monomer concentration and amount of initiator on dye removal in single system, and adsorbent dosage, pH, and initial dye concentration in single and binary systems were evaluated. The dye adsorption isotherm and kinetics were studied. Results indicated that adsorption of BR46 and BB41 onto nanocomposites is well fitted with Langmuir isotherm and the rate of sorption was found to conform to pseudo-second-order kinetic with good correlation. The maximum dye adsorption capacity (Q0) of composites for two different amounts of AA and APS in nanocomposite (0.17 mmol AA + 3.50 mmol APS and 0.26 mmol AA + 6.57 mmol APS) was 2,439.02 and 2,702.70 for BB41, 2,272.72 and 2,380.95 mg/g for BR46 in single system, 2,083.33 and 2,127.65 for BB41, 1,785.71 and 1,923.07 mg/g for BR46 in binary system. Results illustrated that zeolite/acrylic acid nanocomposites could be suggested as an efficient nanoadsorbent to remove cationic dyes from wastewaters.
Colección de canciones andaluzas: Digital edition
Creators: name: Leblanc Elina
Publisher: name: Zenodo
Year: 2022
Subjects: Spanish literature
Digital edition
XML-TEI

description: Digital edition of a Spanish pliego de cordel, published by the Andalusian printer José María Moreno (19th c.). It contains the XML-TEI file of the edition, as well as the files that led to this edition, i.e. the digital facsimiles (raw and retouched), and the transcription produced by the OCR tool Transkribus (PAGE-XML). This digital edition is a part of the research project Desenrollando el cordel / Untangling the cordel / Démêler le cordel (2020-2024), led by the professor Constance Carta at the University of Geneva and supported by the philanthropic Sandoz-Monique de Meuron Family Foundation.
Powering an autonomous clock with quantum electromechanics
Creators: name: Culhane, Oisin
name: Kewming, Michael J.
name: Silva, Alessandro
name: Goold, John
name: Mitchison, Mark T.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We theoretically analyse an autonomous clock comprising a nanoelectromechanical system, which undergoes self-oscillations driven by electron tunnelling. The periodic mechanical motion behaves as the clockwork, similar to the swinging of a pendulum, while induced oscillations in the electrical current can be used to read out the ticks. We simulate the dynamics of the system in the quasi-adiabatic limit of slow mechanical motion, allowing us to infer statistical properties of the clock's ticks from the current auto-correlation function. The distribution of individual ticks exhibits a tradeoff between accuracy, resolution, and dissipation, as expected from previous literature. Going beyond the distribution of individual ticks, we investigate how clock accuracy varies over different integration times by computing the Allan variance. We observe non-monotonic features in the Allan variance as a function of time and applied voltage, which can be explained by the presence of temporal correlations between ticks. These correlations are shown to yield a precision advantage for timekeeping over the timescales that the correlations persist. Our results illustrate the non-trivial features of the tick series produced by nanoscale clocks, and pave the way for experimental investigation of clock thermodynamics using nanoelectromechanical systems.
description: 10 pages, 8 figures
Additional file 1 of Dietary factors and risk of mortality among patients with esophageal cancer: a systematic review
Creators: name: Sun, Li-Ping
name: Lu-Bin Yan
name: Liu, Zhen-Zhen
name: Zhao, Wen-Jing
name: Zhang, Cai-Xia
name: Chen, Yu-Min
name: Lao, Xiang Qian
name: Xudong Liu
Publisher: name: figshare
Year: 2020
Subjects: Medicine
Biotechnology
Cancer
Science Policy

description: Additional file 1: Figure S1. Summary of sensitivity analyses of alcohol consumption and mortality among (a) EC (b) ESCC (c) EAC. Abbreviation: HR, hazard ratio; CI, confidence interval; EC, esophageal cancer; EAC, esophageal adenocarcinoma; ESCC, esophageal squamous cell carcinoma.
Synthesis, crystal structure, and properties of a μ3-oxo-trichromium(III) propionate cluster with pyrazole
Creators: name: Botezat, Olga
name: Filippova, Irina G.
name: Hauser, Jürg
name: Krämer, Karl
name: Decurtins, Silvio
name: Shi-Xia Liu
name: Baca, Svetlana G.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Chemistry
Earth and Environmental Sciences
Biotechnology
Molecular Biology
Cell Biology
Medicine
Physics
Biochemistry
Biophysics

description: A new μ3-oxo trinuclear chromium(III) propionate cluster, [Cr3(μ3-O)(O2CCH2CH3)6(pyr)3]NO3·0.25(H2O) (1), has been synthesized by reaction of a μ3-oxo trinuclear chromium(III) propionate precursor [Cr3(μ3-O)(O2CCH2CH3)6(H2O)3]NO3 with a pyrazole ligand (pyr) and characterized by IR spectroscopy, single-crystal X-ray structure determination, and thermal analysis. Magnetic susceptibility and magnetization studies revealed antiferromagnetic exchange interactions within the trinuclear Cr(III) cluster (J = -11.9 cm−1) and determined the electronic ground state (S = ½) of the compound.