cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Fully Guided Synthetic Osteochondral Resurfacing of a Large Stifle OCD Lesion Using a Patient-Specific Implant and Drill Guides
Creators: name: Moser, Jasmine
name: Haimel, Georg
name: Barker-Benfield, Karen
name: Leschnik, Katharina
name: Böttcher, Peter
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: OCD
subject: stifle
subject: resurfacing
subject: patient-specific
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::617 Chirurgie und verwandte medizinische Einrichtungen
subject: 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

description: Synthetic anatomical reconstruction of extensive, oval osteochondrosis dissecans (OCD) defects remains a challenge due to the ‘one shape fits all’ design of commercial round implants. This is further complicated by the inherent inaccuracy of free-hand implant positioning procedures. A 6-month-old German Shepherd presented with a 15 × 7.8 × 4.3 mm OCD defect at the lateral femoral condyle. A synthetic patient-specific implant (PSI) was designed, using the contralateral unaffected condyle as a template. Reaming of the implant bed was fully guided using a set of three-dimensional-printed drill guides. The implant, consisting of a titanium base and a polycarbonate urethane bearing surface, was press-fit into place. Temporary meniscal release of the cranial meniscal horn was repaired, followed by routine closure and postoperative care. The combination of PSI and matching drill guides resulted in an accurate restoration of the normal joint surface at the former defect area. At 6-week and 18-month follow-ups, mild joint effusion, unexpected soft tissue mineralization and a small joint mouse were present. No other complications were encountered, and the dog was clinically lameness-free. At 6 weeks and 6 months, computerized gait analysis documented increased loading of the affected limb from 36% preoperatively to 42 and 40%, on follow-up, respectively. Body weight distribution between both hindlimbs was nearly equal at the 6-month control with 1% difference in loading. Osteochondral resurfacing using a PSI appears to be a promising treatment option for large stifle OCD lesions in which other treatment modalities may not be eligible.
Towards Probing Conformational States of Y2 Receptor Using Hyperpolarized 129Xe NMR
Creators: name: Schmidt, Peter
name: Vogel, Alexander
name: Schwarze, Benedikt
name: Seufert, Florian
name: Licha, Kai
name: Wycisk, Virginia
name: Kilian, Wolfgang
name: Hildebrand, Peter W.
name: Mitschang, Lorenz
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: GPCR states
subject: Y2R
subject: NMR
subject: hyperpolarized xenon
subject: MD simulation
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

description: G protein-coupled receptors can adopt many different conformational states, each of them exhibiting different restraints towards downstream signaling pathways. One promising strategy to identify and quantify this conformational landscape is to introduce a cysteine at a receptor site sensitive to different states and label this cysteine with a probe for detection. Here, the application of NMR of hyperpolarized 129Xe for the detection of the conformational states of human neuropeptide Y2 receptor is introduced. The xenon trapping cage molecule cryptophane-A attached to a cysteine in extracellular loop 2 of the receptor facilitates chemical exchange saturation transfer experiments without and in the presence of native ligand neuropeptide Y. High-quality spectra indicative of structural states of the receptor–cage conjugate were obtained. Specifically, five signals could be assigned to the conjugate in the apo form. After the addition of NPY, one additional signal and subtle modifications in the persisting signals could be detected. The correlation of the spectroscopic signals and structural states was achieved with molecular dynamics simulations, suggesting frequent contact between the xenon trapping cage and the receptor surface but a preferred interaction with the bound ligand.
Measurement of the beam-helicity asymmetry $I^{\odot}$ in the photoproduction of $π^0π^{\pm}$-pairs off protons and off neutrons
Creators: name: Oberle, M.
name: Ahrens, J.
name: Annand, J. R. M.
name: Arends, H. J.
name: Bantawa, K.
name: Bartolome, P. A.
name: Beck, R.
name: Bekrenev, V.
name: Berghaeuser, H.
name: Braghieri, A.
name: Branford, D.
name: Briscoe, W. J.
name: Brudvik, J.
name: Cherepnya, S.
name: Demissie, B.
name: Dieterle, M.
name: Downie, E. J.
name: Drexler, P.
name: Fil'kov, L. V.
name: Fix, A.
name: Glazier, D. I.
name: Heid, E.
name: Hornidge, D.
name: Howdle, D.
name: Huber, G. M.
name: Jahn, O.
name: Jaegle, I.
name: Jude, T. C.
name: Kaeser, A.
name: Kashevarov, V. L.
name: Keshelashvili, I.
name: Kondratiev, R.
name: Korolija, M.
name: Kruglov, S. P.
name: Krusche, B.
name: Kulbardis, A.
name: Lisin, V.
name: Livingston, K.
name: MacGregor, I. J. D.
name: Maghrbi, Y.
name: Mancell, J.
name: Manley, D. M.
name: Marinides, Z.
name: Martinez, M.
name: McGeorge, J. C.
name: McNicoll, E.
name: Mekterovic, D.
name: Metag, V.
name: Micanovic, S.
name: Middleton, D. G.
name: Mushkarenkov, A.
name: Nefkens, B. M. K.
name: Nikolaev, A.
name: Novotny, R.
name: Ostrick, M.
name: Oussena, B.
name: Pedroni, P.
name: Pheron, F.
name: Polonski, A.
name: Prakhov, S. N.
name: Robinson, J.
name: Rosner, G.
name: Rostomyan, T.
name: Schumann, S.
name: Sikora, M. H.
name: Sober, D. I.
name: Starostin, A.
name: Supek, I.
name: Thiel, M.
name: Thomas, A.
name: Unverzagt, M.
name: Watts, D. P.
name: Werthmueller, D.
name: Witthauer, L.
name: Zehr, F.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: Beam-helicity asymmetries have been measured at the MAMI accelerator in Mainz for the photoproduction of mixed-charge pion pairs in the reactions $\boldsymbolγp\rightarrow nπ^0π^+$ off free protons and $\boldsymbolγd\rightarrow (p)pπ^0π^-$ and $\boldsymbolγd\rightarrow (n)nπ^0π^+$ off quasi-free nucleons bound in the deuteron for incident photon energies up to 1.4 GeV. Circularly polarized photons were produced from bremsstrahlung of longitudinally polarized electrons and tagged with the Glasgow-Mainz magnetic spectrometer. The charged pions, recoil protons, recoil neutrons, and decay photons from $π^0$ mesons were detected in the 4$π$ electromagnetic calorimeter composed of the Crystal Ball and TAPS detectors. Using a complete kinematic reconstruction of the final state, excellent agreement was found between the results for free and quasi-free protons, suggesting that the quasi-free neutron results are also a close approximation of the free-neutron asymmetries. A comparison of the results to the predictions of the Two-Pion-MAID reaction model shows that the reaction mechanisms are still not well understood, in particular at low incident photon energies in the second nucleon-resonance region.
description: accepted for publication in Eur. phys. J. A
Deterioration of headache impact and health-related quality of life in migraine patients after cessation of preventive treatment with CGRP(−receptor) antibodies
Creators: name: Terhart, Maria
name: Mecklenburg, Jasper
name: Neeb, Lars
name: Overeem, Lucas Hendrik
name: Siebert, Anke
name: Steinicke, Maureen
name: Raffaelli, Bianca
name: Reuter, Uwe
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: CGRP(-receptor)
subject: migraine
subject: headache
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background Migraine preventive treatment with CGRP(-receptor) monoclonal antibodies (mAbs) has a positive effect on patients' health-related quality of life (HRQoL). The German treatment guidelines recommend discontinuing successful treatment with CGRP(-receptor) mAbs after 6-12 months. We aimed to evaluate headache-specific and generic HRQoL for three months after discontinuation of CGRP(-receptor) mAb treatment. Methods We conducted a prospective, longitudinal cohort study, including patients with migraine after 8-12 months of therapy with a CGRP(-R) mAb and before a planned discontinuation attempt. HRQoL was assessed at the time of the last mAbs injection (V1), eight weeks later (V2), and sixteen weeks later (V3). For headache-specific HRQoL, we used the Headache Impact Test-6 (HIT-6). Generic HRQoL was determined with the EuroQol-5-Dimension-5-Level (ED-5D-5L) form, and the Short-Form 12 (SF-12), which comprises a Physical Component Summary (PCS-12) and a Mental Component Summary (MCS-12). Questionnaires' total scores were compared across the three observation points using nonparametric procedures. Results The study cohort consisted of n = 61 patients (n = 29 treated with the CGRP-receptor mAb erenumab and n = 32 with the CGRP mAbs galcanezumab or fremanezumab). The HIT-6 sum score was 59.69 +/- 6.90 at V1 and increased by 3.69 +/- 6.21 at V3 (p < 0.001), indicating a greater headache impact on patients' lives. The mean total EQ-D5-L5 score declined from 0.85 +/- 0.17 at V1 by - 0.07 +/- 0.18 at V3 (p = 0.013). Both Mental and Physical Component Scores of the SF-12 worsened significantly during treatment discontinuation: The PCS-12 total score decreased by - 4.04 +/- 7.90 from V1 to V3 (p = 0.013) and the MCS-12 score by - 2.73 +/- 9.04 (p = 0.003). Changes in all questionnaires' scores but the MCS-12 were already significant in the first month of the drug holiday (V2). Conclusions Our results show a significant decline in headache impact and generic HRQoL of migraine patients after treatment discontinuation of a CGRP(-R) mAb. The observed deterioration is above the established minimally clinically important differences for each of the questionnaires and can therefore be considered clinically meaningful. Monitoring HRQoL during a discontinuation attempt could facilitate the decision whether or not to resume preventive treatment with CGRP(-R) mAbs.
Is there a risk to human health from microplastics? More research and scientific data needed
Creators: name: German Federal Institute For Risk Assessment (BfR)
Publisher: name: Zenodo
Year: 2018
Subjects: subject: microplastics
subject: food
subject: human intestinal epithelial cells
subject: absorption
subject: http://id.agrisemantics.org/gacs/C6109

description: The Austrian Federal Environment Agency and the Medical University of Vienna have presented the first preliminary results of a pilot study on microplastics (microplastic particles) in humans. They have detected microplastic particles in stool of eight volunteers. The German Federal Institute for Risk Assessment (BfR) summarises its findings on possible health risks of microplastic particles for humans. Link: https://www.bfr.bund.de/cm/349/is-there-a-risk-to-humal-health-from-microplastics-more-research-and-scientific-data-needed.pdf
description: DE; PDF;efsa-focal-point@bfr.bund.de
The magnetic moments of the proton and the antiproton
Creators: name: Ulmer, S.
name: Mooser, A.
name: Blaum, K.
name: Braeuninger, S.
name: Franke, K.
name: Kracke, H.
name: Leiteritz, C.
name: Matsuda, Y.
name: Nagahama, H.
name: Ospelkaus, C.
name: Rodegheri, C. C.
name: Quint, W.
name: Schneider, G.
name: Smorra, C.
name: Van Gorp, S.
name: Walz, J.
name: Yamazaki, Y.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Recent exciting progress in the preparation and manipulation of the motional quantum states of a single trapped proton enabled the first direct detection of the particle's spin state. Based on this success the proton magnetic moment $μ_p$ was measured with ppm precision in a Penning trap with a superimposed magnetic field inhomogeneity. An improvement by an additional factor of 1000 in precision is possible by application of the so-called double Penning trap technique. In a recent paper we reported the first demonstration of this method with a single trapped proton, which is a major step towards the first direct high-precision measurement of $μ_p$. The techniques required for the proton can be directly applied to measure the antiproton magnetic moment $μ_{\bar{p}}$. An improvement in precision of $μ_{\bar{p}}$ by more than three orders of magnitude becomes possible, which will provide one of the most sensitive tests of CPT invariance. To achieve this research goal we are currently setting up the Baryon Antibaryon Symmetry Experiment (BASE) at the antiproton decelerator (AD) of CERN.
Neurocognitive disorders in the elderly: altered functional resting-state hyperconnectivities in postoperative delirium patients
Creators: name: Winterer, Jeanne M.
name: Ofosu, Kwaku
name: Borchers, Friedrich
name: Hadzidiakos, Daniel
name: Lammers-Lietz, Florian
name: Spies, Claudia
name: Winterer, Georg
name: Zacharias, Norman
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Postoperative delirium (POD)
subject: Neurocognitive disorders
subject: Elderly
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Postoperative delirium (POD) represents a confusional state during days/weeks after surgery and is particularly frequent in elderly patients. Hardly any fMRI studies were conducted to understand the underlying pathophysiology of POD patients. This prospective observational cohort study aims to examine changes of specific resting-state functional connectivity networks across different time points (pre- and 3-5 months postoperatively) in delirious patients compared to no-POD patients. Two-hundred eighty-three elderly surgical patients underwent preoperative resting-state fMRI (46 POD). One-hundred seventy-eight patients completed postoperative scans (19 POD). For functional connectivity analyses, three functional connectivity networks with seeds located in the orbitofrontal cortex (OFC), nucleus accumbens (NAcc), and hippocampus were investigated. The relationship of POD and connectivity changes between both time points (course connectivity) were examined (ANOVA). Preoperatively, delirious patients displayed hyperconnectivities across the examined functional connectivity networks. In POD patients, connectivities within NAcc and OFC networks demonstrated a decrease in course connectivity [max. F = 9.03, p = 0.003; F = 4.47, p = 0.036, resp.]. The preoperative hyperconnectivity in the three networks in the patients at risk for developing POD could possibly indicate existing compensation mechanisms for subtle brain dysfunction. The observed pathophysiology of network function in POD patients at least partially involves dopaminergic pathways.
The tomb next door: An update to ``Statistical analysis of an archeological find''
Creators: name: Feuerverger, Andrey
Publisher: name: arXiv
Year: 2014
Subjects: subject: Applications (stat.AP)
subject: FOS: Computer and information sciences

description: In June of 2010 access via robotic means was obtained to a tomb adjacent to the one studied in Feuerverger [Ann. Appl. Stat. 2 (2008) 3-54]. In this update, we lay out and attempt to interpret the remarkable findings from this second tomb and comment on the statistical and scientific significance of these new data and of their possible inferential connections to the data from the first tomb. Readers are then invited to formulate their own conclusions.
description: Published in at http://dx.doi.org/10.1214/13-AOAS677 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Levels of pharmacologically active opium alkaloids in poppy seeds should be lowered to the minimum technologically achievable level
Creators: name: German Federal Institute For Risk Assessment (BfR)
Publisher: name: Zenodo
Year: 2018
Subjects: subject: opium alkaloide
subject: morphine
subject: poppy seed
subject: acute reference dose
subject: ARfD
subject: http://id.agrisemantics.org/gacs/C21672

description: The ripe seeds of opium poppy are highly regarded for their level of oil and protein, and are used in the manufacture of bakery produce and vegetable oil. The milky sap (latex) of unripe capsules in particular is also used to obtain opium alkaloids for pharmacological purposes. Opium alkaloids include morphine and codeine. The poppy seeds themselves contain only very small quantities of opium alkaloids. However, poppy seeds may be contaminated with alkaloid-containing latex, e.g. during mechanical harvesting processes. The European Food Safety Authority (EFSA) updated its opinion on opium alkaloids in poppy seeds on 16 May 2018 (https://www.efsa.europa.eu/en/efsajournal/pub/5243). The assessment is based on data on morphine and other alkaloids in poppy seed samples. An acute reference dose (ARfD) of 10 μg morphine equivalents per kg body weight (bw) was derived as a group ARfD for morphine and codeine. The ARfD is defined as quantity of a substance which consumers can ingest with food in the course of one day without any recognisable health risk. The BfR agrees with the statements made in the latest EFSA opinion. In compliance with the assessment approach taken by the BfR in 2005, EFSA derived an ARfD starting from the lowest oral single dose which still shows a pharmacological effect. The data upon which the assessment is based show that the morphine content of food poppies varies greatly. For example, the poppy plant variety, time of harvest and the geographical origin may influence the morphine content. With poppy seeds containing high levels of opium alkaloids,, people of all age groups can exceed the derived health-based guidance value. High levels are usually found in varieties bred primary for pharmaceutical purposes. With poppy seeds containing relatively low amounts of opium alkaloids, , an exceedance is possible only for high consumers. Low levels commonly originate from varieties cultivated for food use. The BfR still recommends that all efforts should be made to lower levels of pharmacologically active opium alkaloids in poppy seeds to the technologically feasible minimum. Since, latest EFSA exposure estimates also showed that people of all age groups can exceed the healthbased guidance level, especially when poppy seeds with high opium alkaloid levels are consumed, the BfR still advises against excessive consumption of foods containing high amounts of poppy seeds, especially during pregnancy. Link: https://www.bfr.bund.de/cm/349/levels-of-pharmacologically-active-opium-alkaloids-in-poppy-seeds-shoul-be-lowered-to-the-minimum-technologically-achievable-level.pdf
description: DE; PDF; efsa-focal-point@bfr.bund.de
Isoglucose and sucrose (household sugar) can be assessed similarly in terms of the potential to damage health
Creators: name: German Federal Institute For Risk Assessment (BfR)
Publisher: name: Zenodo
Year: 2018
Subjects: subject: isoglucose
subject: saccharose
subject: sugar
subject: high-fructose corn syrup
subject: HFCS
subject: health risks
subject: sweeteners
subject: http://id.agrisemantics.org/gacs/C12367

description: Isoglucose, also known as high-fructose corn syrup (HFCS), is used in the food industry as a substance to sweeten processed foods such as soft drinks, creams, cakes, confectionery, yogurts etc. The Federal Institute for Risk Assessment (BfR) has been asked by various parties whether these sweeteners, which contain a high proportion of the free monosaccharide (simple sugar) fructose, pose a particular risk to health as compared to other sweeteners such as sucrose (household sugar, beet sugar, cane sugar). Isoglucose contains variable amounts of the simple sugars glucose and fructose in unconnected forms. This means that the two sugars are present as monosaccharides. In comparison, sucrose also contains glucose and fructose, but in this case the sugars are present in a connected form in a ratio of exactly one-to-one as a disaccharide. In the variants of isoglucose that are frequently used at the present time, the two monomers glucose and fructose are present in roughly comparable amounts; with respect to the fructose level, the difference as compared to sucrose is relatively low. In this case, it can be expected that there are no differences or no significant differences between isoglucose and sucrose from a nutritional perspective and that their health assessments are thus also similar. However, the prerequisite for this is that the intake level of added sugars does not increase significantly overall. If isoglucose variants with a significantly higher proportion of fructose are to be added to processed foods, it must be pointed out that the consumption of high amounts of fructose can have adverse effects on the metabolism. In concrete terms, it can contribute to metabolic syndrome as well as lipometabolic disorders, fatty liver, obesity and diabetes mellitus type 2. In addition, there are known intolerances to fructose. It is considered scientifically proven that regular excessive consumption of sugar added to foods (including added fructose) is detrimental to health and should be reduced. Consumers should ensure that their daily intake of added sugar does not exceed 10 % of their total daily intake of energy from food, including beverages. The consumption of added sugar should be even lower if possible. Therefore, an adult with energy requirements of approximately 2000 kilocalories should not consume more than 6 - 12 teaspoons of added sugar per day from all food, including beverages. Link: https://www.bfr.bund.de/cm/349/isoglucose-and-sucrose-household-sugar-can-be-assessed-similarly-in-terms-of-the-potential-to-damage-health.pdf
description: DE; PDF; efsa-focal-point@bfr.bund.de
Planetary companion in K giant Sigma Persei
Creators: name: Lee, Byeong-Cheol
name: Han, Inwoo
name: Park, Myeong-Gu
name: Mkrtichian, David E.
name: Jeong, Gwanghui
name: Kim, Kang-Min
name: Valyavin, Gennady
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We report the detection of an exoplanet candidate in orbit around sigma Persei from a radial velocity (RV) survey. The system exhibits periodic RV variations of 579.8 +/- 2.4 days. The purpose of the survey is to search for low-amplitude and long-period RV variations in giants and examine the origin of the variations using the fiber-fed Bohyunsan Observatory Echelle Spectrograph installed at the 1.8-m telescope of Bohyunsan Optical Astronomy Observatory in Korea. We present high-accuracy RV measurements of sigma Per made from December 2003 to January 2014. We argue that the RV variations are not related to the surface inhomogeneities but instead a Keplerian motion of the planetary companion is the most likely explanation. Assuming a stellar mass of 2.25 +/- 0.5 M_Sun, we obtain a minimum planetary companion mass of 6.5 +/- 1.0 M_Jup, with an orbital semi-major axis of 1.8 +/- 0.1 AU, and an eccentricity of 0.3 +/- 0.1 around sigma Per.
description: 9 pages, 6 fiures, 3 tables
Semantic Census Presentation 2023
Creators: name: Nenova, Denitsa
name: Bruseker, George
Publisher: name: Zenodo
Year: 2023

description: This presentation stands as a final update on the Semantic Census project as presented in a workshop held at the premises of Humboldt University in Berlin from 25 - 27 of 2023. The presentation summarizes the goals and outcomes of the project as well as presenting an agenda of work for the workshop itself.
Extremal Eigenvalues of the Laplacian on Euclidean domains and closed surfaces
Creators: name: Colbois, Bruno
name: Soufi, Ahmad El
Publisher: name: arXiv
Year: 2014
Subjects: subject: Metric Geometry (math.MG)
subject: FOS: Mathematics

description: We investigate properties of the sequences of extremal values that could be achieved by the eigenvalues of the Laplacian on Euclidean domains of unit volume, under Dirichlet and Neumann boundary conditions, respectively. In a second part, we study sequences of extremal eigenvalues of the Laplace-Beltrami operator on closed surfaces of unit area.
Current reversals in rapidly rotating ultra-cold Fermi gases
Creators: name: Bencheikh, K.
name: Medjedel, S.
name: Vignale, G.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We study the equilibrium current density profiles of harmonically trapped ultra-cold Fermi gases in quantum Hall-like states that appear when the quasi-two-dimensional trap is set in fast rotation. The density profile of the gas (in the rotating reference frame) consists of incompressible strips of constant quantized density separated by compressible regions in which the density varies. Remarkably, we find that the atomic currents flow in opposite directions in the compressible and incompressible regions -- a prediction that should be amenable to experimental verification.
description: 5 pages, 2 figures
BfR calculator for estimating consumer exposure to biocide residues in food
Creators: name: German Federal Institute For Risk Assessment (BfR)
Publisher: name: Zenodo
Year: 2018
Subjects: subject: biocides
subject: residues
subject: consumer exposure
subject: http://id.agrisemantics.org/gacs/C21233
subject: http://id.agrisemantics.org/gacs/C29232

description: Regulation (EU) No. 528/2012 requires that a risk assessment is performed for products containing biocidal active substances. The assessment includes the evaluation of residues in food and feed. Through the use of biocides in domestic households by non-professional users food can be exposed. This may occur either via direct exposure of food or upon contact of food items with biocide residues deposited on surfaces. With active participation of the German Federal Institute for Risk Assessment (BfR) the Working Group ARTFood (Biocidal Product Committee Ad hoc Working Group for the Assessment of Residue Transfer into Foods) of the European Chemicals Agency (ECHA) has developed the “Guidance on Estimating Dietary Risk from Transfer of Biocidal Active Substances into Foods – Non-professional Uses” (Guidance Non-Prof Uses). The document has been published on the ECHA website as part of the Guidance on the Biocidal Products Regulation [1]. The Guidance Non-Prof Uses proposes several scenarios for estimating consumer exposure to biocidal active substances in their food. In order to facilitate harmonized exposure estimates the BfR has developed an Excel-based tool for calculating the exposure for various scenarios. Calculations are based on assumptions and default values as described in the Guidance Non-Prof Uses. Calculator and guidance are intended to support competent authorities and industry in the estimation of dietary risk to humans from biocidal products that are used in domestic environments (households) and could contaminate food. https://www.bfr.bund.de/cm/349/bfr-calculator-for-estimating-consumer-exposure-to-biocide-residues-in-food.pdf
description: DE; PDF; efsa-focal-point@bfr.bund.de
Bounding the Higgs width at the LHC: complementary results from $H \to WW$
Creators: name: Campbell, John M.
name: Ellis, R. Keith
name: Williams, Ciaran
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We investigate the potential of the process $gg \to H \to WW$ to provide bounds on the Higgs width. Recent studies using off-shell $H\rightarrow ZZ$ events have shown that Run 1 LHC data can constrain the Higgs width, $Γ_H < (25-45) Γ_{H}^{\rm SM}$. Using 20 fb-1 of 8 TeV ATLAS data, we estimate a bound on the Higgs boson width from the WW channel between $Γ_H < (100-500) Γ_H^{SM}$. The large spread in limits is due to the range of cuts applied in the existing experimental analysis. The stricter cuts designed to search for the on-shell Higgs boson limit the potential number of off-shell events, weakening the constraints. As some of the cuts are lifted the bounds improve. We show that there is potential in the high transverse mass region to produce upper bounds of the order of $(25-50) Γ_H^{SM}$, depending strongly on the level of systematic uncertainty that can be obtained. Thus, if these systematics can be controlled, a constraint on the Higgs boson width from the $H \to WW$ decay mode can complement a corresponding limit from $H \to ZZ$.
description: 8 pages, 5 figures
Hydraulic Resistance of Grass Media on Shallow Overland Flow
Creators: name: Tao, David K.
name: Barfield, Billy J.
name: Lyons, Austin E.
Publisher: name: Kentucky Water Resources Research Institute, University of Kentucky
Year: 1977

description: Abstract:
Simulated dense vegetation with random blade arrangements and different blade flexibilities were used to determine the hydraulic properties of flow of small, non-submerging depths. With the water flowing among the randomly patterned vegetation blades, drag resistance becomes the dominant force that retards the flow. An equation of flow was established based on the momentum balance in the system. Experimental results were used to determine the coefficient of blade resistance, RD, and plotted in terms of blade width and flow depth Reynolds number respectively.
Funding information: The work on which this report is based was supported in part by funds by the Office of Water Research and Technology, United States Department of the Interior, as authorized under the Water Resources Research Act of 1964.
Idealized computational models for auditory receptive fields
Creators: name: Lindeberg, Tony
name: Friberg, Anders
Publisher: name: arXiv
Year: 2014
Subjects: subject: Sound (cs.SD)
subject: Neurons and Cognition (q-bio.NC)
subject: FOS: Computer and information sciences
subject: FOS: Biological sciences

description: This paper presents a theory by which idealized models of auditory receptive fields can be derived in a principled axiomatic manner, from a set of structural properties to enable invariance of receptive field responses under natural sound transformations and ensure internal consistency between spectro-temporal receptive fields at different temporal and spectral scales. For defining a time-frequency transformation of a purely temporal sound signal, it is shown that the framework allows for a new way of deriving the Gabor and Gammatone filters as well as a novel family of generalized Gammatone filters, with additional degrees of freedom to obtain different trade-offs between the spectral selectivity and the temporal delay of time-causal temporal window functions. When applied to the definition of a second-layer of receptive fields from a spectrogram, it is shown that the framework leads to two canonical families of spectro-temporal receptive fields, in terms of spectro-temporal derivatives of either spectro-temporal Gaussian kernels for non-causal time or the combination of a time-causal generalized Gammatone filter over the temporal domain and a Gaussian filter over the logspectral domain. For each filter family, the spectro-temporal receptive fields can be either separable over the time-frequency domain or be adapted to local glissando transformations that represent variations in logarithmic frequencies over time. Within each domain of either non-causal or time-causal time, these receptive field families are derived by uniqueness from the assumptions. It is demonstrated how the presented framework allows for computation of basic auditory features for audio processing and that it leads to predictions about auditory receptive fields with good qualitative similarity to biological receptive fields measured in the inferior colliculus (ICC) and primary auditory cortex (A1) of mammals.
description: 55 pages, 22 figures, 3 tables
Semantic Census Presentation 2021 Marburg
Creators: name: Nenova, Denitsa
name: Bruseker, George
name: Christian, Kathleen
name: Engel, Franz
Publisher: name: Zenodo
Year: 2023

description: This presentation was created as a joint contribution to Forum Standards for 4Culture Data on May 3, 2021 by Kathleen Christian & Franz Engel (HU Berlin) Denitsa Nenova & George Bruseker (Takin.solutions). It stands as an initial report on the goals and progress of the Semantic Census project in 2021. The presentation explains the overall work of upgrading the Census project system of record (EasyDB/FYLR) and explains how the updated version of the Census data will be mapped to the CIDOC CRM and made available as an open RDF dataset for reuse by the community using new semantic based research methods.
Primary headaches during the COVID-19 lockdown in Germany: analysis of data from 2325 patients using an electronic headache diary
Creators: name: Raffaelli, Bianca
name: Mecklenburg, Jasper
name: Scholler, Simon
name: Overeem, Lucas Hendrik
name: Oliveira Gonçalves, Ana Sofia
name: Reuter, Uwe
name: Neeb, Lars
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: COVID-19
subject: Lockdown
subject: Primary headache
subject: Migraine
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background Lockdown measures due to the COVID-19 pandemic have led to lifestyle changes, which in turn may have an impact on the course of headache disorders. We aimed to assess changes in primary headache characteristics and lifestyle factors during the COVID-19 lockdown in Germany using digital documentation in the mobile application (app) M-sense. Main body We analyzed data of smartphone users, who entered daily data in the app in the 28-day period before lockdown (baseline) and in the first 28 days of lockdown (observation period). This analysis included the change of monthly headache days (MHD) in the observation period compared to baseline. We also assessed changes in monthly migraine days (MMD), the use of acute medication, and pain intensity. In addition, we looked into the changes in sleep duration, sleep quality, energy level, mood, stress, and activity level. Outcomes were compared using paired t-tests. The analysis included data from 2325 app users. They reported 7.01 +/- SD 5.64 MHD during baseline and 6.89 +/- 5.47 MHD during lockdown without significant changes (p > 0.999). MMD, headache and migraine intensity neither showed any significant changes. Days with acute medication use were reduced from 4.50 +/- 3.88 in the baseline to 4.27 +/- 3.81 in the observation period (p < 0.001). The app users reported reduced stress levels, longer sleep duration, reduced activity levels, along with a better mood, and an improved energy level during the first lockdown month (p <= 0.001). In an extension analysis of users who continued to use M-sense every day for 3 months after initiation of lockdown, we compared the baseline and the subsequent months using repeated-measures ANOVA. In these 539 users, headache frequency did not change significantly neither (6.11 +/- 5.10 MHD before lockdown vs. 6.07 +/- 5.17 MHD in the third lockdown month, p = 0.688 in the ANOVA). Migraine frequency, headache and migraine intensity, and acute medication use were also not different during the entire observation period. Conclusion Despite slight changes in factors that contribute to the generation of headache, COVID-19-related lockdown measures did not seem to be associated with primary headache frequency and intensity over the course of 3 months.
Statistical study of free magnetic energy and flare productivity of solar active regions
Creators: name: Su, J. T.
name: Jing, J.
name: Wang, S.
name: Wiegelmann, T.
name: Wang, H. M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Photospheric vector magnetograms from Helioseismic and Magnetic Imager on board the Solar Dynamic Observatory are utilized as the boundary conditions to extrapolate both non-linear force-free and potential magnetic fields in solar corona. Based on the extrapolations, we are able to determine the free magnetic energy (FME) stored in active regions (ARs). Over 3000 vector magnetograms in 61 ARs were analyzed. We compare FME with ARs' flare index (FI) and find that there is a weak correlation ($<60\%$) between FME and FI. FME shows slightly improved flare predictability relative to total unsigned magnetic flux of ARs in the following two aspects: (1) the flare productivity predicted by FME is higher than that predicted by magnetic flux and (2) the correlation between FI and FME is higher than that between FI and magnetic flux. However, this improvement is not significant enough to make a substantial difference in time-accumulated FI, rather than individual flare, predictions.
description: The paper was submitted to ApJ and it is accepted now
MECHANICS AND DYNAMICS OF PARTICLE NETWORK IN COMPOSITE ELECTRODES
Creators: name: Sharma, Nikhil
Publisher: name: Purdue University Graduate School
Year: 2023
Subjects: classificationCode: 401707
subject: Solid mechanics
classificationCode: 401601
subject: Ceramics
classificationCode: 340604
subject: Electrochemistry
classificationCode: 400404
subject: Electrochemical energy storage and conversion

description: Energy storage devices have become an integral part of the digital infrastructure of the 21st century. Li-ion batteries are a widely used chemical form of energy storage devices comprising components with varied chemical, mechanical and electrochemical properties. Over long-term usage, the anode and cathode experience spatially heterogeneous Li reaction, mechanical degradation, and reversible capacity loss. The small particle size and environmental sensitivity of materials used in Li-ion battery materials make investigating electrodes' electrochemical and mechanical properties an arduous task. Nevertheless, understanding the effect of electrochemical fatigue load (during the battery's charging and discharging process) on composite electrodes' mechanical stability is imperative to design and manufacture long-lasting energy storage devices.Due to the low-symmetry lattice, Lithium Nickel Manganese Cobalt Oxide (NMC) cathode materials exhibit direction-dependent (anisotropic) mechanical properties. In this Dissertation, we first measure the anisotropic elastic stiffness of NMC cathode material using nano-indentation. We also determine the effect of Ni stoichiometry on the indentation modulus, hardness, and fracture toughness of NMC materials. The complete information on the mechanical properties of cathode materials will enable accurate computational results and the design of robust cathodes.Further, using operando optical experiments, we report that NMC porous composite cathode experiences asynchronous reactions only during the 1st charging process. Non-uniform carbon binder network coverage across the cathode and Li concentration-dependent material properties of NMC results in the initial asynchronous phenomenon. The information on the degree of electrochemical conditioning of Li-ion battery cathode obtained from optical microscopy can test the consistency of product quality in the industrial manufacturing process. We also investigate the effects of non-uniform reactions on active material’s local morphology change and study the evolution of particle network over long-term cycling. Reported data from experiments depicts that in the early cycles, individual particles’ characteristics significantly influence the degree of damage across the cathode.However, the interaction with neighboring particles becomes more influential in later cycles. Computational modeling uses a multiphysics-based theoretical framework to explain the interplay between electrochemical activity and mechanical damage. The methodology, theoretical framework, and experimental procedure detailed here will enable the design of efficient composite electrodes for long-lasting batteries.
The non-linear evolution of jet quenching
Creators: name: Iancu, Edmond
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We construct a generalization of the JIMWLK Hamiltonian, going beyond the eikonal approximation, which governs the high-energy evolution of the scattering between a dilute projectile and a dense target with an arbitrary longitudinal extent (a nucleus, or a slice of quark-gluon plasma). Different physical regimes refer to the ratio $L/τ$ between the longitudinal size $L$ of the target and the lifetime $τ$ of the gluon fluctuations. When $L/τ\ll 1$, meaning that the target can be effectively treated as a shockwave, we recover the JIMWLK Hamiltonian, as expected. When $L/τ\gg 1$, meaning that the fluctuations live inside the target, the new Hamiltonian governs phenomena like the transverse momentum broadening and the radiative energy loss, which accompany the propagation of an energetic parton through a dense QCD medium. Using this Hamiltonian, we derive a non-linear equation for the dipole amplitude (a generalization of the BK equation), which describes the high-energy evolution of jet quenching. As compared to the original BK-JIMWLK evolution, the new evolution is remarkably different: the plasma saturation momentum evolves much faster with increasing energy (or decreasing Bjorken's $x$) than the corresponding scale for a shockwave (nucleus). This widely opens the transverse phase-space for the evolution and implies the existence of large radiative corrections, enhanced by the double logarithm $\ln^2(LT)$, with $T$ the temperature of the medium. This confirms and explains from a physical perspective a recent result by Liou, Mueller, and Wu (arXiv:1304.7677). The dominant corrections are smooth enough to be absorbed into a renormalization of the jet quenching parameter $\hat q$. This renormalization is controlled by a linear equation supplemented with a saturation boundary, which emerges via controlled approximations from the generalized BK equation alluded to above.
description: 54 pages plus 4 appendices, 6 figures
Estudio experimental sobre el uso de Learning Analytics Dashboard (LAD) como una posible contribución a la evaluación de la competencia investigativa en un contexto de aprendizaje combinado en pregrado
Creators: name: Diaz-Montenegro, Diego Mauricio
name: Rieckmann, Marco
Publisher: name: Zenodo
Year: 2023
Subjects: learning analytics
learning analytics dashboard
moodle
evaluación de competencias

description: En los programas de contaduría pública en Colombia, se promueve el desarrollo de habilidades de investigación a través de estrategias como la realización de trabajos de grado en el último año de estudio. A pesar de los esfuerzos de las universidades para fomentar estas habilidades en los estudiantes, la evaluación de la capacidad de investigación por parte de los directores de tesis no siempre aborda de manera integral el conjunto de habilidades necesarias para la competencia investigativa. Por esta razón, esta propuesta de investigación tiene como objetivo validar la contribución de las analíticas del aprendizaje al proceso de evaluación de competencias realizado por los directores de tesis en programas de contaduría pública a nivel de pregrado. Este objetivo se logrará a través de una combinación de métodos que incluyen una revisión sistemática de la literatura, un experimento con grupo de control preprueba y posprueba, entre otros. Estos métodos permitirán implementar y evaluar la efectividad de un Learning Analytics Dashboard (LAD) en el contexto de aprendizaje mixto.
Semantic Census Presentation 2021
Creators: name: Bruseker, George
Publisher: name: Zenodo
Year: 2023

description: This presentation was created for the first meeting of the Census Project and Takin.solutions, starting to establish the grounds for generating a semantic version of the Census dataset. In this presentation, the use of semantics in general are presented and the main aspects of the CIDOC CRM are outlined. The meeting took place at premises of Humboldt University in Berlin on 23/11/2021.
Dicke-type phase transition in a spin-orbit coupled Bose-Einstein condensate
Creators: name: Hamner, Chris
name: Qu, Chunlei
name: Zhang, Yongping
name: Chang, JiaJia
name: Gong, Ming
name: Zhang, Chuanwei
name: Engels, Peter
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: Spin-orbit coupled Bose-Einstein condensates (BECs) provide a powerful tool to investigate interesting gauge-field related phenomena. We study the ground state properties of such a system and show that it can be mapped to the well-known Dicke model in quantum optics, which describes the interactions between an ensemble of atoms and an optical field. A central prediction of the Dicke model is a quantum phase transition between a superradiant phase and a normal phase. Here we detect this transition in a spin-orbit coupled BEC by measuring various physical quantities across the phase transition. These quantities include the spin polarization, the relative occupation of the nearly degenerate single particle states, the quantity analogous to the photon field occupation, and the period of a collective oscillation (quadrupole mode). The applicability of the Dicke model to spin-orbit coupled BECs may lead to interesting applications in quantum optics and quantum information science.
description: 9 pages, 8 figures
IPBES Invasive Alien Species Assessment, data management report for Scenarios and Models Liaison
Creators: name: Lenzner, Bernd
name: Vicente, Joana
name: Roy, Helen E.
Publisher: name: Zenodo
Year: 2021
Subjects: Data management report

description: - Systematic literature review has been conducted by authors to analyse scenarios and models aspect of invasive alien species for IPBES thematic assessment of invasive alien species and their control. - List of references extracted from a search in ISI Web of Science and Scopus including information on the Authors, Title, Keywords, Abstracts and Journal. This search was based on a predefined set of keywords related to alien species, scenarios and models. The extracted references were screened in an inclusion/exclusion procedure to select relevant references for the extended literature review. - Full references of the selected references (as pdf) that have been identified in the inclusion/exclusion procedure for the extended literature review.
Successive filament eruptions within one solar breakout event
Creators: name: Shen, Yuandeng
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The magnetic breakout model has been widely used to explain solar eruptive activities. Here, we apply it to explain successive filament eruptions occurred in a quadrupolar magnetic source region. Based on the high temporal and spatial resolution, multi-wavelengths observations taken by the Atmospheric Imaging Assembly (AIA) on board the Solar Dynamic Observatory (SDO), we find some signatures that support the occurrence of breakout-like external reconnection just before the start of the successive filament eruptions. Furthermore, the extrapolated three-dimensional coronal field also reveals that the magnetic topology above the quadrupolar source region resembles that of the breakout model. We propose a possible mechanism within the framework of the breakout model to interpret the successive filament eruptions, in which the so-called magnetic implosion mechanism is firstly introduced to be the physical linkage of successive filament eruptions. We conclude that the structural properties of coronal fields are important for producing successive filament eruptions.
description: 4 pages, 2 figures. Published in Proceedings IAU Symposium No. 8 Symposium S300. For this version, I include the color figures in the paper