cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The late chlamydial inclusion membrane is not derived from the endocytic pathway and is relatively deficient in host proteins.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: Chlamydiae are obligate intracellular parasites which multiply within infected cells in a membrane-bound structure termed an inclusion. Newly internalized bacteria are surrounded by host plasma membrane; however, the source of membrane for the expansion of the inclusion is unknown. To determine if the membrane for the mature inclusion was derived by fusion with cellular organelles, we stained infected cells with fluorescent or electron-dense markers specific for organelles and examined inclusions for those markers. We observed no evidence for the presence of endoplasmic reticulum, Golgi, late endosomal, or lysosomal proteins in the inclusion. These data suggest that the expansion of the inclusion membrane, beginning 24 h postinoculation, does not occur by the addition of host proteins resulting from either de novo host synthesis or by fusion with preexisting membranes. To determine the source of the expanding inclusion membrane, antibodies were produced against isolated membranes from Chlamydia-infected mouse cells. The antibodies were demonstrated to be solely against Chlamydia-specified proteins by both immunoprecipitation of [35S]methionine-labeled extracts and Western blotting (immunoblotting). Techniques were used to semipermeabilize Chlamydia-infected cells without disrupting the permeability of the inclusion, allowing antibodies access to the outer surface of the inclusion membrane. Immunofluorescent staining demonstrated a ring-like fluorescence around inclusions in semipermeabilized cells, whereas Triton X-100-permeabilized cells showed staining throughout the inclusion. These studies demonstrate that the inclusion membrane is made up, in part, of Chlamydia-specified proteins and not of existing host membrane proteins.
S2W2
Creators: name: Alyssah Clavien
Year: 2023
Subjects: subject: Mesoamerica
valueUri: https://core.tdar.org/browse/geographic-keyword/61/mesoamerica
subject: Basin of Mexico
valueUri: https://core.tdar.org/browse/geographic-keyword/3/basin-of-mexico
subject: Mexico
valueUri: https://core.tdar.org/browse/geographic-keyword/134/mexico
subject: Mexico (State / Territory)
valueUri: https://core.tdar.org/browse/geographic-keyword/326/mexico-state-territory
subject: United Mexican States (Country)
valueUri: https://core.tdar.org/browse/geographic-keyword/438/united-mexican-states-country
subject: Central Mexico, Teotihuacan Valley
valueUri: https://core.tdar.org/browse/geographic-keyword/7/central-mexico-teotihuacan-valley
subject: Central Mexico
valueUri: https://core.tdar.org/browse/geographic-keyword/135/central-mexico
subject: Teotihuacan Valley
valueUri: https://core.tdar.org/browse/geographic-keyword/154/teotihuacan-valley
subject: Teotihuacan
valueUri: https://core.tdar.org/browse/geographic-keyword/202/teotihuacan
subject: Valley of Mexico
valueUri: https://core.tdar.org/browse/geographic-keyword/44/valley-of-mexico
subject: Classic Period
valueUri: https://core.tdar.org/browse/temporal-keyword/125/classic-period
subject: Terminal Formative
valueUri: https://core.tdar.org/browse/temporal-keyword/67/terminal-formative
subject: Teotihuacan Period
valueUri: https://core.tdar.org/browse/temporal-keyword/7765/teotihuacan-period
subject: Early Classic
valueUri: https://core.tdar.org/browse/temporal-keyword/5560/early-classic
subject: Teotihuacan
valueUri: https://core.tdar.org/browse/culture-keyword/7527/teotihuacan
subject: Teotihuacano
valueUri: https://core.tdar.org/browse/culture-keyword/9224/teotihuacano
subject: Teotihuacan
valueUri: https://core.tdar.org/browse/site-name/92/teotihuacan
subject: Town / City
valueUri: https://core.tdar.org/browse/site-type/255/town-city
subject: Domestic Structure or Architectural Complex
valueUri: https://core.tdar.org/browse/site-type/251/domestic-structure-or-architectural-complex
subject: Settlements
valueUri: https://core.tdar.org/browse/site-type/252/settlements
subject: Systematic Survey
valueUri: https://core.tdar.org/browse/investigation-type/12/systematic-survey

description: Site Survey Form Scan for Square S2W2.
Vesicles containing Chlamydia trachomatis serovar L2 remain above pH 6 within HEC-1B cells.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1996

description: Chlamydia trachomatis serovar L2 is an obligate intracellular bacterium which is internalized in target epithelial cells by endocytosis and resides within a membrane-bound vesicle. Over the next several hours following entry, individual serovar L2-containing vesicles fuse with one another to form a single membrane-bound vesicle (or inclusion) within which the microcolony develops. The experiments reported here directly examined the pH of vesicles containing chlamydiae. The pH was determined by measuring emission ratios of the fluorescent, pH-sensitive probe SNAFL (5-[and 6-]-carboxyseminaphthofluorescein-1, succinimidyl ester) conjugated to chlamydiae. The pH remained above 6.0 at 2, 4, and 12 h after infection, while the pH of vesicles contained heat-killed organisms fell 5.3. In the presence of amines, which raise the pH of acidic compartments, C. trachomatis inclusion formation was unaffected. Inactivation of Na+,K+ -ATPases, the ion pumps responsible for maintaining a pH above 6 within early endocytic vesicles, inhibited the growth of C. trachomatis within epithelial cells. Preventing vesicular acidification by inhibiting the vacuolar proton ATPase did not affect chlamydial growth. Thus, chlamydiae do not reside within highly acidic vesicles and avoid the pathway leading to lysosomes.
N2E5
Creators: name: Alyssah Clavien
Year: 2023
Subjects: subject: Mesoamerica
valueUri: https://core.tdar.org/browse/geographic-keyword/61/mesoamerica
subject: Basin of Mexico
valueUri: https://core.tdar.org/browse/geographic-keyword/3/basin-of-mexico
subject: Mexico
valueUri: https://core.tdar.org/browse/geographic-keyword/134/mexico
subject: Mexico (State / Territory)
valueUri: https://core.tdar.org/browse/geographic-keyword/326/mexico-state-territory
subject: United Mexican States (Country)
valueUri: https://core.tdar.org/browse/geographic-keyword/438/united-mexican-states-country
subject: Central Mexico, Teotihuacan Valley
valueUri: https://core.tdar.org/browse/geographic-keyword/7/central-mexico-teotihuacan-valley
subject: Central Mexico
valueUri: https://core.tdar.org/browse/geographic-keyword/135/central-mexico
subject: Teotihuacan Valley
valueUri: https://core.tdar.org/browse/geographic-keyword/154/teotihuacan-valley
subject: Teotihuacan
valueUri: https://core.tdar.org/browse/geographic-keyword/202/teotihuacan
subject: Valley of Mexico
valueUri: https://core.tdar.org/browse/geographic-keyword/44/valley-of-mexico
subject: Classic Period
valueUri: https://core.tdar.org/browse/temporal-keyword/125/classic-period
subject: Terminal Formative
valueUri: https://core.tdar.org/browse/temporal-keyword/67/terminal-formative
subject: Teotihuacan Period
valueUri: https://core.tdar.org/browse/temporal-keyword/7765/teotihuacan-period
subject: Early Classic
valueUri: https://core.tdar.org/browse/temporal-keyword/5560/early-classic
subject: Teotihuacan
valueUri: https://core.tdar.org/browse/culture-keyword/7527/teotihuacan
subject: Teotihuacano
valueUri: https://core.tdar.org/browse/culture-keyword/9224/teotihuacano
subject: Teotihuacan
valueUri: https://core.tdar.org/browse/site-name/92/teotihuacan
subject: Town / City
valueUri: https://core.tdar.org/browse/site-type/255/town-city
subject: Domestic Structure or Architectural Complex
valueUri: https://core.tdar.org/browse/site-type/251/domestic-structure-or-architectural-complex
subject: Settlements
valueUri: https://core.tdar.org/browse/site-type/252/settlements
subject: Systematic Survey
valueUri: https://core.tdar.org/browse/investigation-type/12/systematic-survey

description: Site Survey Form Scan for Square N2E5.
Characterization of the diversity and the transferrin-binding domain of gonococcal transferrin-binding protein 2.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: The molecular weight heterogeneities of Tbp1 and Tbp2 among a panel of 45 gonococcal isolates were assessed. The tbpB genes from four of these strains were sequenced to characterize the Tbp2 sequence diversity among gonococci. By expressing truncated versions of gonococcal Tbp2, we delimited the extent of Tbp2 necessary for transferrin binding in a Western blot.
N2W3
Creators: name: Alyssah Clavien
Year: 2023
Subjects: subject: Mesoamerica
valueUri: https://core.tdar.org/browse/geographic-keyword/61/mesoamerica
subject: Basin of Mexico
valueUri: https://core.tdar.org/browse/geographic-keyword/3/basin-of-mexico
subject: Mexico
valueUri: https://core.tdar.org/browse/geographic-keyword/134/mexico
subject: Mexico (State / Territory)
valueUri: https://core.tdar.org/browse/geographic-keyword/326/mexico-state-territory
subject: United Mexican States (Country)
valueUri: https://core.tdar.org/browse/geographic-keyword/438/united-mexican-states-country
subject: Central Mexico, Teotihuacan Valley
valueUri: https://core.tdar.org/browse/geographic-keyword/7/central-mexico-teotihuacan-valley
subject: Central Mexico
valueUri: https://core.tdar.org/browse/geographic-keyword/135/central-mexico
subject: Teotihuacan Valley
valueUri: https://core.tdar.org/browse/geographic-keyword/154/teotihuacan-valley
subject: Teotihuacan
valueUri: https://core.tdar.org/browse/geographic-keyword/202/teotihuacan
subject: Valley of Mexico
valueUri: https://core.tdar.org/browse/geographic-keyword/44/valley-of-mexico
subject: Classic Period
valueUri: https://core.tdar.org/browse/temporal-keyword/125/classic-period
subject: Terminal Formative
valueUri: https://core.tdar.org/browse/temporal-keyword/67/terminal-formative
subject: Teotihuacan Period
valueUri: https://core.tdar.org/browse/temporal-keyword/7765/teotihuacan-period
subject: Early Classic
valueUri: https://core.tdar.org/browse/temporal-keyword/5560/early-classic
subject: Teotihuacan
valueUri: https://core.tdar.org/browse/culture-keyword/7527/teotihuacan
subject: Teotihuacano
valueUri: https://core.tdar.org/browse/culture-keyword/9224/teotihuacano
subject: Teotihuacan
valueUri: https://core.tdar.org/browse/site-name/92/teotihuacan
subject: Town / City
valueUri: https://core.tdar.org/browse/site-type/255/town-city
subject: Domestic Structure or Architectural Complex
valueUri: https://core.tdar.org/browse/site-type/251/domestic-structure-or-architectural-complex
subject: Settlements
valueUri: https://core.tdar.org/browse/site-type/252/settlements
subject: Systematic Survey
valueUri: https://core.tdar.org/browse/investigation-type/12/systematic-survey

description: Site Survey Form Scan for Square N2W3.
Perfect state transfer in products and covers of graphs
Creators: name: Coutinho, Gabriel
name: Godsil, Chris
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: Quantum Physics (quant-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: A continuous-time quantum walk on a graph $X$ is represented by the complex matrix $\exp (-\mathrm{i} t A)$, where $A$ is the adjacency matrix of $X$ and $t$ is a non-negative time. If the graph models a network of interacting qubits, transfer of state among such qubits throughout time can be formalized as the action of the continuous-time quantum walk operator in the characteristic vectors of the vertices. Here we are concerned with the problem of determining which graphs admit a perfect transfer of state. More specifically, we will study graphs whose adjacency matrix is a sum of tensor products of $01$-matrices, focusing on the case where a graph is the tensor product of two other graphs. As a result, we will construct many new examples of perfect state transfer.
description: 15 pages
N2E6
Creators: name: Alyssah Clavien
Year: 2023
Subjects: subject: Mesoamerica
valueUri: https://core.tdar.org/browse/geographic-keyword/61/mesoamerica
subject: Basin of Mexico
valueUri: https://core.tdar.org/browse/geographic-keyword/3/basin-of-mexico
subject: Mexico
valueUri: https://core.tdar.org/browse/geographic-keyword/134/mexico
subject: Mexico (State / Territory)
valueUri: https://core.tdar.org/browse/geographic-keyword/326/mexico-state-territory
subject: United Mexican States (Country)
valueUri: https://core.tdar.org/browse/geographic-keyword/438/united-mexican-states-country
subject: Central Mexico, Teotihuacan Valley
valueUri: https://core.tdar.org/browse/geographic-keyword/7/central-mexico-teotihuacan-valley
subject: Central Mexico
valueUri: https://core.tdar.org/browse/geographic-keyword/135/central-mexico
subject: Teotihuacan Valley
valueUri: https://core.tdar.org/browse/geographic-keyword/154/teotihuacan-valley
subject: Teotihuacan
valueUri: https://core.tdar.org/browse/geographic-keyword/202/teotihuacan
subject: Valley of Mexico
valueUri: https://core.tdar.org/browse/geographic-keyword/44/valley-of-mexico
subject: Classic Period
valueUri: https://core.tdar.org/browse/temporal-keyword/125/classic-period
subject: Terminal Formative
valueUri: https://core.tdar.org/browse/temporal-keyword/67/terminal-formative
subject: Teotihuacan Period
valueUri: https://core.tdar.org/browse/temporal-keyword/7765/teotihuacan-period
subject: Early Classic
valueUri: https://core.tdar.org/browse/temporal-keyword/5560/early-classic
subject: Teotihuacan
valueUri: https://core.tdar.org/browse/culture-keyword/7527/teotihuacan
subject: Teotihuacano
valueUri: https://core.tdar.org/browse/culture-keyword/9224/teotihuacano
subject: Teotihuacan
valueUri: https://core.tdar.org/browse/site-name/92/teotihuacan
subject: Town / City
valueUri: https://core.tdar.org/browse/site-type/255/town-city
subject: Domestic Structure or Architectural Complex
valueUri: https://core.tdar.org/browse/site-type/251/domestic-structure-or-architectural-complex
subject: Settlements
valueUri: https://core.tdar.org/browse/site-type/252/settlements
subject: Systematic Survey
valueUri: https://core.tdar.org/browse/investigation-type/12/systematic-survey

description: Site Survey Form Scan for Square N2E6.
Differences in the association of Chlamydia trachomatis serovar E and serovar L2 with epithelial cells in vitro may reflect biological differences in vivo.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: Chlamydia trachomatis serovar E is one of the most common bacterial sexually transmitted pathogens. Since it is an obligate intracellular bacterium, efficient colonization of genital mucosal epithelial cells is crucial to the infectious process. Serovar E elementary bodies (EB) metabolically radiolabeled with 35S-Cys-Met and harvested from microcarrier bead cultures, which significantly improves the infectious EB-to-particle ratio, provided a more accurate picture of the parameters of attachment of EB to human endometrial epithelial cells (HEC-1B) than did less infectious 14C-EB harvested from flask cultures. Binding of serovar E EB was (i) equivalent at 35 and 4 degrees C, (ii) decreased by preexposure of EB to heat or the topical microbicide C31G, (iii) comparable among common eukaryotic cell lines (HeLa, McCoy), and (iv) significantly increased to the apical surfaces of polarized cells versus nonpolarized cells. In parallel experiments with C. trachomatis serovar L2, serovar E attachment was not affected by heparin or heparan sulfate whereas these glucosaminoglycans dramatically reduced serovar L2 attachment. These data were confirmed by competitive inhibition of serovar E binding and infectivity by excess unlabeled live and UV-inactivated serovar E EB but not by excess serovar L2 EB. The noninvasive serovar E strains in the lumen of the genital tract enter and exit the apical domains of target columnar epithelial cells to spread canalicularly in an ascending fashion from the lower to the upper genital tract. In contrast, the invasive serovar L2 strains are primarily submucosal pathogens and likely use the glucosaminoglycans concentrated in the extracellular matrix to colonize the basolateral domains of mucosal epithelia to perpetuate the infectious process.
Imaging timing after glioblastoma surgery (INTERVAL-GB): protocol for a UK and Ireland, multicentre retrospective cohort study.
Creators: name: Gillespie, Conor S
name: Bligh, Emily R
name: Poon, Michael TC
name: Solomou, Georgios
name: Islim, Abdurrahman I
name: Mustafa, Mohammad A
name: Rominiyi, Ola
name: Williams, Sophie T
name: Kalra, Neeraj
name: Mathew, Ryan K
name: Booth, Thomas C
name: Thompson, Gerard
name: Brennan, Paul M
name: Jenkinson, Michael D
name: INTERVAL-GB Collaborative
name: British Neurosurgical Trainee Research Collaborative (BNTRC)
name: Neurology And Neurosurgery Interest Group (NANSIG)
name: Neurology And Neurosurgery Interest Group
Publisher: name: Apollo - University of Cambridge Repository
Year: 2022
Subjects: Oncology
1506
1717
NEUROSURGERY
Neurological oncology
Neuroradiology

description: Peer reviewed: True
description: Acknowledgements: We would like to thank all investigators, patients, and collaborators in helping to design, conceptualise, and contribute to the study.
description: INTRODUCTION: Glioblastoma is the most common malignant primary brain tumour with a median overall survival of 12-15 months (range 6-17 months), even with maximal treatment involving debulking neurosurgery and adjuvant concomitant chemoradiotherapy. The use of postoperative imaging to detect progression is of high importance to clinicians and patients, but currently, the optimal follow-up schedule is yet to be defined. It is also unclear how adhering to National Institute for Health and Care Excellence (NICE) guidelines-which are based on general consensus rather than evidence-affects patient outcomes such as progression-free and overall survival. The primary aim of this study is to assess MRI monitoring practice after surgery for glioblastoma, and to evaluate its association with patient outcomes. METHODS AND ANALYSIS: ImagiNg Timing aftER surgery for glioblastoma: an eVALuation of practice in Great Britain and Ireland is a retrospective multicentre study that will include 450 patients with an operated glioblastoma, treated with any adjuvant therapy regimen in the UK and Ireland. Adult patients ≥18 years diagnosed with glioblastoma and undergoing surgery between 1 August 2018 and 1 February 2019 will be included. Clinical and radiological scanning data will be collected until the date of death or date of last known follow-up. Anonymised data will be uploaded to an online Castor database. Adherence to NICE guidelines and the effect of being concordant with NICE guidelines will be identified using descriptive statistics and Kaplan-Meier survival analysis. ETHICS AND DISSEMINATION: Each participating centre is required to gain local institutional approval for data collection and sharing. Formal ethical approval is not required since this is a service evaluation. Results of the study will be reported through peer-reviewed presentations and articles, and will be disseminated to participating centres, patients and the public.
Sediment microbial communities associated with bioturbators around remnant oyster reefs
Creators: name: Palmer, Julia
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: The effects of biodiversity on ecosystem function have gained significant interest as global species loss continues. In estuarine sediments, microbial communities and their capacity to cycle nitrogen is influenced by bioturbating benthic macrofauna (bioturbators) and the burrow structures they create. Oyster reefs also influence microbial communities and their function by enriching surrounding sediments, which can increase bioturbator activity and nitrogen cycling bacteria. However, the interactions between sediment microbes and bioturbators, and consequences for ecosystem functions have not been fully explored. This study sampled sediment microbial DNA and in situ flux measurements of oxygen and nitrogen to assess how bioturbator activity can modulate microbial biodiversity and function at six remnant oyster reefs along the east coast of Australia. While bioturbator burrows were found to have similar microbial community composition and functioning to that of the surrounding surface sediments, these communities were related to bioturbation activity measured as number of burrows. Moreover, bioturbation activity explained sediment oxygen consumption, while the composition of core microbial communities explained gas fluxes between sediments and water column. This study highlights the importance of microbial sediment diversity and the functional roles of bioturbators in influencing biogeochemical cycles in estuarine sediments.
Supplementary document for Internally focused Phase Optical Transfer Function (iPOTF) for Spatial Light Interference Microscopy (SLIM) - 7148936.pdf
Creators: name: Fang, Jingde
name: Liu, Peng
name: Smith, Zachary
name: Chu, Kaiqin
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: supplemental material
Nilpotent Symmetries of a 4D Model of the Hodge Theory: Augmented (Anti-)Chiral Superfield Formalism
Creators: name: Shukla, A.
name: Srinivas, N.
name: Malik, R. P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We derive the continuous nilpotent symmetries of the four (3 + 1)-dimensional (4D) model of the Hodge theory (i.e. 4D Abelian 2-form gauge theory) by exploiting the beauty and strength of the symmetry invariant restrictions on the (anti-)chiral superfields. The above off-shell nilpotent symmetries are the Becchi-Rouet-Stora-Tyutin (BRST), anti-BRST and (anti-)co-BRST transformations which turn up beautifully due to the (anti-)BRST and (anti-)co-BRST invariant restrictions on the (anti-)chiral superfields that are defined on the (4, 1)-dimensional (anti-)chiral super-submanifolds of the general (4, 2)-dimensional supermanifold on which our ordinary 4D theory is generalized. The latter supermanifold is characterized by the superspace coordinates $Z^M = (x^μ,\, θ,\, \barθ)$ where $x^μ\, (μ= 0, 1, 2, 3 )$ are the bosonic coordinates and a pair of Grassmannian variables $θ$ and $\barθ$ are fermionic in nature as they obey the standard relationships: $θ^2 = {\barθ}^2 = 0,\, θ\,\barθ+ \barθ\,θ= 0$). The derivation of the {\it proper} (anti-)co-BRST symmetries and proof of the absolute anticommutativity property of the conserved (anti-)BRST and (anti-) co-BRST charges are novel results of our present investigation (where only the (anti-)chiral superfields and their super-expansions have been taken into account).
description: LaTeX file, 28 pages, journal reference is given
Response of Chlamydia trachomatis serovar E to iron restriction in vitro and evidence for iron-regulated chlamydial proteins.
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1997

description: Iron is a well-established mediator of virulence in several bacterial pathogens, yet little is known about the role of iron in infectious disease processes caused by obligate intracellular bacterial pathogens. In this study, the effect of iron limitation was examined for the sexually transmitted infectious agent Chlamydia trachomatis in an in vitro model of human genital infection using the intracellular iron-chelating reagent deferoxamine mesylate (Desferal). Iron restriction caused a significant reduction in infectivity of C. trachomatis elementary bodies (EB) harvested from Desferal-exposed polarized epithelial cells when compared to that of EB harvested from iron-sufficient control cell cultures. Replacement of the Desferal exposure medium with medium containing iron-saturated transferrin restored chlamydial infectivity, whereas replacement with growth medium alone had no effect. The following three prominent morphological features were observed by electron microscopic examination of chlamydia-infected cells exposed to Desferal: (i) inclusions containing chlamydiae greatly delayed in maturation, (ii) substantial blebbing within chlamydial inclusions, and (iii) electron-dense material surrounding inclusions. Protein analyses of highly purified EB by two-dimensional polyacrylamide gel electrophoresis revealed that there were at least 19 candidate iron-repressible proteins in C. trachomatis and at least one protein which was iron inducible. One putative iron-repressible protein was confirmed by Western blot (immunoblot) analysis to be the chlamydial heat shock protein 60 (hsp60). The enhanced production of this antigen by chlamydiae as a result of iron limitation is of particular importance since there is a well-documented association between chlamydial hsp60 and destructive immunopathological sequelae in infected patients.
Supplementary document for Multimodal segmentation of dynamic subcellular features using quantitative phase imaging and FRET-based sensors - 7086040.pdf
Creators: name: Wax, Adam
name: Highland, Robert
name: Rancu, Albert
name: Price, Hillel
name: Parker, Steven
name: Reynolds, Meghan
name: Hoffman, Brenton
Publisher: name: Optica Publishing Group
Year: 2024
Subjects: Uncategorized

description: Supplemental Document
Transitivity of conservative toral endomorphisms
Creators: name: Andersson, Martin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 37A05, 37B99

description: It is shown that if a non-invertible area preserving local homeomorphism on $\mathbb{T}^2$ is homotopic to a linear expanding or hyperbolic endomorphism, then it must be topologically transitive. This gives a complete characterization, in any smoothness category, of those homotopy classes of conservative endomorphisms that consist entirely of transitive maps.
description: 11 pages
Cloning and Characterization of tdhA, a Locus Encoding a TonB-Dependent Heme Receptor from Haemophilus ducreyi
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Haemophilus ducreyi is unable to synthesize heme and must acquire it from its only known host, humans. We cloned and sequenced a gene encoding an outer membrane receptor for heme. It was designated tdhA (for TonB-dependent heme receptor A) since it was related by sequence homology to the family of TonB-dependent receptors. TdhA was strikingly similar to open reading frame HI0113 from the genome of Haemophilus influenzae Rd and also shared homology with five other heme receptors, including HxuC, HemR, HmuR, ChuA, and ShuA, from gram-negative bacteria. An Escherichia coli hemA tonB mutant strongly expressing H. ducreyi tdhA grew on low levels of heme as a source of heme only when an intact H. ducreyi Ton system plasmid was present, formally demonstrating functional TonB dependence. tdhA was expressed poorly in vitro by H. ducreyi and only under conditions of heme limitation. A survey of H. ducreyi revealed that all tested strains but one synthesized small amounts of TdhA in vitro under heme-limiting conditions. Surprisingly, an isogenic mutant of tdhA as well as its parent, 35000, both required the same high levels of heme for growth (50 μg/ml [77 μM] on agar medium). This result, together with previous findings, suggests that in vitro, the uptake of heme by H. ducreyi is mediated by a TonB- and TdhA-independent mechanism, possibly diffusion.
Integrating quantum groups over surfaces
Creators: name: Ben-Zvi, David
name: Brochier, Adrien
name: Jordan, David
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Algebra (math.QA)
subject: Algebraic Geometry (math.AG)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics
subject: 16T99

description: We apply the mechanism of factorization homology to construct and compute category-valued two-dimensional topological field theories associated to braided tensor categories, generalizing the $(0,1,2)$-dimensional part of Crane-Yetter-Kauffman 4D TFTs associated to modular categories. Starting from modules for the Drinfeld-Jimbo quantum group $U_q(\mathfrak g)$ we obtain in this way an aspect of topologically twisted 4-dimensional ${\mathcal N}=4$ super Yang-Mills theory, the setting introduced by Kapustin-Witten for the geometric Langlands program. For punctured surfaces, in particular, we produce explicit categories which quantize character varieties (moduli of $G$-local systems) on the surface; these give uniform constructions of a variety of well-known algebras in quantum group theory. From the annulus, we recover the reflection equation algebra associated to $U_q(\mathfrak g)$, and from the punctured torus we recover the algebra of quantum differential operators associated to $U_q(\mathfrak g)$. From an arbitrary surface we recover Alekseev's moduli algebras. Our construction gives an intrinsically topological explanation for well-known mapping class group symmetries and braid group actions associated to these algebras, in particular the elliptic modular symmetry (difference Fourier transform) of quantum $\mathcal D$-modules.
description: 57 page, 5 figures. Final version, to appear in J. Top
Expression of β-Defensin Genes in Bovine Alveolar Macrophages
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Bovine alveolar macrophages (BAM) were examined for the expression of β-defensins and to determine whether their expression could be upregulated by bacterial lipopolysaccharide (LPS), as observed with β-defensins expressed in bovine tracheal epithelial cells. Four β-defensins were expressed constitutively in BAM, with bovine neutrophil β-defensin (BNBD)-4 and BNBD-5 being the most predominant. This is the first evidence of β-defensin gene expression in a mature myeloid cell. LPS had no effect on β-defensin expression in BAM, even though tumor necrosis factor alpha (TNF-α) production was induced. Nonbacterial inflammatory particles had little effect on β-defensin gene expression or TNF-α production in BAM. We hypothesize that constitutively expressed β-defensins of alveolar macrophages may have a role in lung host defense.
Planck's constant measurement by Landauer quantization for students laboratories
Creators: name: Damyanov, Desislav S.
name: Pavlova, Iliana N.
name: Ilieva, Simona I.
name: Gourev, Vassil N.
name: Yordanov, Vasil G.
name: Mishonov, Todor M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Physics Education (physics.ed-ph)
subject: FOS: Physical sciences

description: A simple experimental setup for measuring the Planck's constant, using Landauer quantization of the conductance between touching gold wires, is described. It consists of two gold wires with thickness of 0.5 mm and 1.5 cm length, and an operational amplifier. The setup costs less than $30 and can be realized in every teaching laboratory in two weeks. The usage of oscilloscope is required.
description: English text: 10 pages, 7 figures, Experimental setup description for teaching laboratory; Bulgarian translation: 10 pages, same 7 figures
Haemophilus ducreyi Infection Causes Basal Keratinocyte Cytotoxicity and Elicits a Unique Cytokine Induction Pattern in an In Vitro Human Skin Model
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Haemophilus ducreyi is the etiologic agent of the sexually transmitted genital ulcer disease chancroid. Predominantly a cutaneous pathogen, H. ducreyi is present in chancroid ulcers that are characterized by extensive neutrophil accumulation in intraepidermal lesions accompanied by a mononuclear infiltrate in the dermis. We used an in vitro human skin model composed of foreskin fibroblasts and keratinocytes to examine host skin cell interactions with H. ducreyi 35000. Bacteria replicated and persisted in artificial skin for at least 14 days. We observed H. ducreyi inside suprabasal keratinocytes using transmission electron microscopy. Although no bacteria were seen in the basal keratinocyte region, these cells were disrupted in infected cocultures. H. ducreyi infection stimulated increased secretion of interleukin-6 (IL-6) and IL-8 by skin cells. Conversely, tumor necrosis factor alpha and IL-1α levels were not elevated. IL-8 produced in response to H. ducreyi infection may be involved in recruiting polymorphonuclear leukocytes and other inflammatory cells, thereby contributing to the tissue necrosis and ulcer formation characteristic of chancroid.
МАЛЕНЬКАЯ ПОЭМА ВАСИЛИЯ ФЕДОРОВА «ГАМЛЕТ В СОВХОЗЕ» КАК ЛИРИЧЕСКИЙ НАРРАТИВ
Creators: name: Лебединская, Виктория
Publisher: name: ООО Цифра
Year: 2022
Subjects: small poem
motifs of suffering and co-suffering
lyrical subject
lyric-epic style
lyrical narrativity
universal sympathy
маленькая поэма
мотивы страдания и со-страдания
лирический субъект
лиро-эпический стиль
лирическая нарративность
всемирная отзывчивость

description: Russian Linguistic Bulletin, Выпуск 7 (35) 2022
Localization of Chlamydia trachomatis Heat Shock Proteins 60 and 70 during Infection of a Human Endometrial Epithelial Cell Line In Vitro
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Unlike chlamydial lipopolysaccharide, which is released from the developing inclusion to the surface of infected genital epithelial cells, both Chlamydia trachomatis heat shock protein (hsp) 60 and 70 antigens remained confined within the inclusion during the course of the chlamydial developmental cycle. Exposure of the infected cells to penicillin to induce a persistent infection or to a lipophilic microbicide did not potentiate secretion or exocytosis of the chlamydial hsp.
Sharing and Reuse of Open and Fair Data: Insights from the ARIADNE Surveys
Creators: name: Geser, Guntram
Publisher: name: Zenodo
Year: 2022
Subjects: Archaeology
FAIR
Data reuse

description: In recent years the principles of open and FAIR data have been adopted by ever more research funders with the goal that data collected or generated by projects become publicly accessible and reuseable. In this endeavour data reuse is seen as a key indicator for a return on investment in research projects, data repositories and networking infrastructure. The impact of this expectation is increasingly felt also in the archaeological research and data management community. This contribution to the session will focus on what is known about the sharing, access to and reuse of archaeological data from the largest available surveys of the ARIADNE data infrastructure initiative. Surveys have been carried out in 2013 and 2019 with participation of researchers, directors of research organisations and project and repository data 422 managers. A survey in 2021 also specifically investigated how well archaeological repositories comply with the FAIR principles. From this rich record of surveys results concerning requirements for open and FAIR archaeological data and emerging practices will be presented, for example, identified patterns in researchers’ sharing and reuse of different data resources or what would help repositories most to support open data access and reuse (e.g., in terms of policies and standards). The presentation will provide insights into the landscape of archaeological data sharing and reuse as a background for examples of specific cases.
Symmetric webs, Jones-Wenzl recursions and $q$-Howe duality
Creators: name: Rose, David E. V.
name: Tubbenhauer, Daniel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Algebra (math.QA)
subject: Geometric Topology (math.GT)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics

description: We define and study the category of symmetric $\mathfrak{sl}_2$-webs. This category is a combinatorial description of the category of all finite dimensional quantum $\mathfrak{sl}_2$-modules. Explicitly, we show that (the additive closure of) the symmetric $\mathfrak{sl}_2$-spider is (braided monoidally) equivalent to the latter. Our main tool is a quantum version of symmetric Howe duality. As a corollary of our construction, we provide new insight into Jones-Wenzl projectors and the colored Jones polynomials.
description: 32 pages, lots of figures, comments welcome
Zigzag diagrams and Martin boundary
Creators: name: Tarrago, Pierre
Publisher: name: arXiv
Year: 2015
Subjects: subject: Probability (math.PR)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: We investigate the asymptotic behavior of random paths on a graded graph which describes the subword order for words in two letters. This graph, denoted by $\mathcal{Z}$, has been introduced by Viennot, who also discovered a remarkable bijection between paths on $\mathcal{Z}$ and sequences of permutations. Later on, Gnedin and Olshanski used this bijection to describe the set of Gibbs measures on this graph. Both authors also conjectured that the Martin boundary of $\mathcal{Z}$ should coincide with its minimal boundary. We give here a proof of this conjecture by describing the distribution of a large random path conditioned on having a prescribed endpoint. We also relate paths on the graph Z with paths on the Young lattice, and we finally give a central limit theorem for the Plancherel measure on the set of paths in $\mathcal{Z}$.
description: Published at https://projecteuclid.org/euclid.aop/1535097635 in the Annals of Probability (https://www.imstat.org/journals-and-publications/annals-of-probability/) by the Institute of Mathematical Statistics (https://www.imstat.org/)
Molecular Characterization of Treponema pallidum mcp2, a Putative Chemotaxis Protein Gene
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: The nucleotide sequence of the Treponema pallidum mcp2 gene was determined. mcp2 encodes a 45.8-kDa protein whose deduced amino acid sequence has significant homology with the C-terminal region of bacterial methyl-accepting chemotaxis proteins (MCPs). The Mcp2 N terminus lacks the hydrophobic transmembrane regions present in most MCPs. An Mcp2 fusion protein was strongly reactive with antibody (HC23) to the highly conserved domain of MCPs and with rabbit syphilitic serum. Antibody HC23 reacted with six T. pallidum proteins, including a 45-kDa protein that may correspond to Mcp2. This protein was present in the aqueous phase from T. pallidum cells that were solubilized with Triton X-114 and phase partitioned.
Innovative Digital Start-Ups and their Venture Creation Process with Enabling Digital Platforms
Creators: name: Makarainen-suni, Irma
Publisher: name: University of Westminster
Year: 2021
Subjects: digital entrepreneurship, venture creation process, digital innovation, digital platforms, digital business models

description: Start-ups have gained media attention since Google, Facebook and Amazon were launched in the 1990s. The book Lean Start-up, published in 2011, was another important milestone for digital start-up literature. As unicorn companies emerge around the world, topics highlighted in the news include the vast amount of capital that digital start-ups are raising, the ways in which these digital ventures are disrupting industries, and their global impact on digital economy. However, digital start-ups, digital venture ideas, and their venture creation process lack a unified venture creation model, as there is a gap in the re-search on entrepreneurial processes in a digital context. This research is an explorative study of the venture creation process of innovative digital start-ups that examines what is missing from entrepreneurial process models in a digital technology context and investi-gates how early stage digital start-ups conduct the venture creation process, starting with the pre-phase of antecedents and ending with the launch and scaling of the venture. The research proposes a novel process model of innovative digital start-up venture crea-tion and describes the nature and patterns of the process. A conceptual model was devel-oped based on the entrepreneurship, information systems, and digital innovation litera-ture and empirically assessed with a multi-method qualitative research design. The data collected from semi-structured interviews, internet sources, and observation field notes covered 34 innovative digital start-ups and their founders. Interviews were conducted in-ternationally in high-ranking start-up ecosystems, and the data were analysed with the-matic analysis and fact-checked by triangulating internet data sources. The contribution to entrepreneurship theory is a new illustrative model of the venture creation process of innovative digital start-ups, including the emergent outcome of the process having a digi-tal artefact at its core (e.g., mobile apps, web-based solutions, digital platforms, software solutions, and digital ecosystems). Digital platforms and their multiple roles in the process are presented, as well as the role of critical events as moderators of the process which trigger new development cycles. During the venture creation process, the recombining of digital technologies, modules, and components enabled by digital infrastructures, plat-forms, and ecosystem partners represent digital technology affordances. This recombina-tion provides opportunities for asset-free development of digital venture ideas.
Neisseria gonorrhoeae Heme Biosynthetic Mutants Utilize Heme and Hemoglobin as a Heme Source but Fail To Grow within Epithelial Cells
Creators: name: The University of North Carolina at Chapel Hill University Libraries
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1998

description: Many bacterial pathogens, including pathogenic neisseriae, can use heme as an iron source for growth. To study heme utilization by Neisseria gonorrhoeae, two heme biosynthetic mutants were constructed, one with a mutation in hemH (the gene encoding ferrochelatase) and one with a mutation in hemA (the gene encoding γ-glutamyl tRNA reductase). The hemH mutant failed to grow without an exogenous supply of heme or hemoglobin, whereas the hemA mutant failed to grow unless heme, hemoglobin, or heme precursors were present. Growth of the mutants with hemoglobin required expression of the hemoglobin receptor (HpuAB) and was TonB dependent. However, growth with heme required neither HpuAB nor TonB. An fbpA mutant grew normally when either heme or hemoglobin was present in the medium. The heme biosynthetic mutants showed reduced intracellular survival, compared to the parent strain, within A-431 endocervical epithelial cell cultures. These studies demonstrate that in addition to synthesizing their own heme, N. gonorrhoeae strains are able to internalize and utilize exogenous heme independently of FbpA but appear unable to obtain heme from within epithelial cells for growth.
Thermodynamic aspects of dark energy fluids
Creators: name: Barboza, Edésio M.
name: Nunes, Rafael C.
name: Abreu, Éverton M. C.
name: Neto, Jorge Ananias
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: In this paper we have investigated the limits imposed by thermodynamics on a dark energy fluid. We have obtained the heat capacities and the compressibilities for a dark energy fluid. The thermal and mechanical stabilities require these quantities to be positive. We have shown that dark energy fluids must satisfy the stability conditions and that such requirement put difficulties in the cosmic fluid models with negative constant EoS parameters. We have also shown that the observational constraints imposed by SN Ia, BAO and $H(z)$ data on a general dark energy fluid with a time-dependent EoS parameter are in conflict with the constraints imposed by thermodynamics. This result indicates that dark energy fluid models are unphysical.
description: 7 pages, 1 figure, 1 table. This an updated version of the article originally named "Is this the end of dark energy?"
title: Le yaourt au ferment de figuier chez les Aït Bouycef
Creators: name: Garaoun, Massinissa
Publisher: name: Pangloss
Year: 2023
Subjects: subject: Linguistique
subject: Tasahlit

description: Précisions dialectales : il s'agit du parler des Aït Bouycef (appelé dans la langue ṯaḇuysefṯ) appartenant à la fraction des Aït El-Aârch. Ce parler est classé parmi les variétés de la tasahlit occidentale
description: Préparation traditionelle du yaourt ou fromage au ferment de figuier chez les Aït Bouycef
A unified field theory I: The quantization of gravity
Creators: name: Gerhardt, Claus
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: Mathematical Physics (math-ph)
subject: Differential Geometry (math.DG)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: In a former paper we proposed a model for the quantization of gravity by working in a bundle $E$ where we realized the Hamilton constraint as the Wheeler-DeWitt equation. However, the corresponding operator only acts in the fibers and not in the base space. Therefore, we now discard the Wheeler-DeWitt equation and express the Hamilton constraint differently, either with the help of the Hamilton equations or by employing a geometric evolution equation. There are two modifications possible which both are equivalent to the Hamilton constraint and which lead to two new models. In the first model we obtain a hyperbolic operator that acts in the fibers as well as in the base space and we can construct a symplectic vector space and a Weyl system. \nd In the second model the resulting equation is a wave equation in $\so \times (0,\infty)$ valid in points $(x,t,ξ)$ in $E$ and we look for solutions for each fixed $ξ$. This set of equations contains as a special case the equation of a quantized cosmological Friedmann universe without matter but with a cosmological constant, when we look for solutions which only depend on $t$. Moreover, in case $\so$ is compact we prove a spectral resolution of the equation.
description: This paper has been published in ATMP 22 (2018) under the title "The quantization of gravity". The title of the arXiv version, however, will remain unchanged since it had been referred to under the original title in a number of other papers
Drones: Revolutionizing Indian Agriculture
Creators: name: Nikhil Thakur, Mahital Jamwal, Brajeshwar Singh and Tamanna Sharma
Publisher: name: The Science world a Monthly e magazine
Year: 2023

description: India's economy is mostly based on agriculture. For the vast majority of rural households, agriculture continues to be their main source of income. A significant amount of India's exports are agricultural products, which are another important component of its economy. Despite the growing importance of agriculture, the industry is still lagging behind in terms of technical development. The main causes of this situation have been cropping failure owing to unfavorable weather and unmanaged pest problems. Researchers, farmers, and managers of natural resources must understand how plants, animals, and landscapes as a whole are impacted by shifting environmental conditions and other stresses in order to maximize resilience and productivity. A promising method for describing landscapes, specific plants and animals, and the numerous pressures they face is remote sensing with drones