cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Lattice Evidence for Gauge Field Localization on a Brane
Creators: name: Dimopoulos, P.
name: Farakos, K.
name: Kehagias, A.
name: Koutsoumbas, G.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We examine the problem of gauge-field localization in higher-dimensional gauge theories. In particular, we study a five-dimensional U(1) by lattice techniques and we find that gauge fields can indeed be localized. Two models are considered. The first one has anisotropic couplings independent of each other and of the coordinates. It can be realized on a homogeneous but anisotropic flat Euclidean space. The second model has couplings depending on the extra transverse fifth direction. This model can be realized by a U(1) gauge theory on the Randall-Sundrum background. We find that in both models a new phase exists, the layer phase, in which a massless photon is localized on the four-dimensional layers. We find that this phase is separated from the strong coupling phase by a second order phase transition.
description: Latex, 24 pages, 12 figures
Addendum to "Subgroup commutativity degrees of finite groups" $\left[\text{J. Algebra 321 (2009), 2508-2520}\right]$
Creators: name: Tărnăuceanu, Marius
Publisher: name: arXiv
Year: 2018
Subjects: subject: Group Theory (math.GR)
subject: FOS: Mathematics

description: We indicate a natural generalization of the concept of subgroup commutativity degree of a finite group and a list of open problems on these new concepts.
N=1 Dual String Pairs and Gaugino Condensation
Creators: name: Kachru, S.
name: Silverstein, E.
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study a class of four-dimensional N=1 heterotic string theories which have nontrivial quantum dynamics arising from asymptotically free gauge groups. These models are obtained by orbifolding 4d N=2 heterotic/type II dual pairs by symmetries which leave unbroken products of nonabelian gauge groups (without charged matter) in a ``hidden sector'' on the heterotic side. Such models are expected to break supersymmetry through gaugino condensation in the hidden sector. We find a dual description of the effects of gaugino condensation on the type II side, where the corresponding superpotential arises at tree level. We speculate that the conformal field theory underlying the type II description may be related to a class of geometrical nonsupersymmetric string compactifications.
description: 18 pages, harvmac big; Typos and references corrected
Population syntheses of millisecond pulsars from the Galactic Disk and Bulge
Creators: name: Gonthier, Peter L.
name: Harding, Alice K.
name: Ferrara, Elizabeth C.
name: Frederick, Sara E.
name: Mohr, Victoria E.
name: Koh, Yew-Meng
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present the results of a population synthesis of radio and gamma-ray millisecond pulsars (MSPs) from the Galactic Disk (GD). Using 92 radio millisecond pulsars detected in 13 radio surveys and 54 Fermi MSPs detected as point sources in the first point source catalog, we establish six free parameters corresponding to the overall factor and the exponents of the period and period derivative dependence for each of the radio and gamma-ray empirical luminosity models. We test three high-energy emission models described by the two pole caustic Slot Gap, Outer Gap, and Pair Starved Polar Cap geometries. The simulated distributions of pulsar properties adequately describe the distributions of detected MSPs from the GD. We explore the gamma-ray emission from groups of MSPs in globular clusters and in the Galactic Bulge. The simulation predicts reasonable numbers of Fermi MSPs detected in the other point source catalogs and anticipates a bright future for Fermi observations of MSPs, expecting a total of ~ 170 MSP detections from the GD within ten years. Our numbers of simulated MSPs in globular clusters are in agreement with those derived from Fermi detections. The simulation predicts about 11,000 MSPs in the Galactic Bulge are required to explain the gamma-ray Galactic Center Excess.
description: 37 pages, 21 figures, accepted for publication in ApJ
Cerenkov Photon Density Fluctuations in Extensive Air Showers
Creators: name: Chitnis, V. R.
name: Bhat, P. N.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The details of Cerenkov light produced by a gamma ray or a cosmic ray incident at the top of the atmosphere is best studied through systematic simulations of the extensive air showers. Recently such studies have become all the more important in view of the various techniques resulting from such studies, to distinguish gamma ray initiated showers from those generated by much more abundant hadronic component of cosmic rays. We have carried out here such systematic simulation studies using CORSIKA package in order to understand the Cerenkov photon density fluctuations for 5 different energies at various core distances both for gamma ray and proton primaries incident vertically at the top of the atmosphere. Such a systematic comparison of shower to shower density fluctuations for gamma ray and proton primaries is carried out for the first time here. It is found that the density fluctuations are significantly non-Poissonian. Such fluctuations are much more pronounced in the proton primaries than gamma ray primaries at all energies. The processes that contribute significantly to the observed fluctuations have been identified. It has been found that significant contribution to fluctuations comes from photons emitted after shower maximum. The electron number fluctuations and correlated emission of Cerenkov photons are mainly responsible for the observed fluctuations.
description: 31 pages, latex, 16 figures in ps files, Accepted for publication in "Astroparticle Physics"
Tenthredo lucorum Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Tenthredinidae
Tenthredo
Tenthredo lucorum

description: Tenthredo lucorum [spec. nov.]
T. antennis clavatis nigris, corpore villoso atro. Faun. svec. 927.
Habitat in Betula Alno.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 555, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Zircon as a recorder of the oxygen fugacity of magmas
Creators: name: Burnham, Antony David
Publisher: name: Imperial College London
Year: 2012

description: Zircon (ZrSiO4) is a durable mineral found in most igneous rocks; it is highly retentive of the trace element concentrations it acquires at crystallisation, and its high initial concentrations of U and Th relative to Pb make it the most important mineral for radiometric dating. Therefore, it is a valuable archive of magmatic processes, particularly with regard to those occurring on the early Earth. Based on crystal chemistry, anomalous Ce and Eu concentrations in zircon relative to other rare earth elements (REE) seem likely to reflect the oxidation state of the magma. Zircons were grown experimentally under controlled conditions of oxygen fugacity (fO2) and the crystals and coexisting glass were analysed by SIMS and LA-ICP-MS to examine the covariation of the partition coefficients of Ce and Eu, as well as those of other trace elements. This revealed that with increasing fO2, Ce becomes more compatible and Eu and U become less compatible. There is a narrow window of fO2s in which a Ce and a Eu anomaly coexist. Literature data allow the partitioning data obtained for the heavy REE in this study to be extrapolated to other temperatures. To allow extrapolation of the partitioning experiments, Ce- and Eu-doped glasses of various melt compositions were prepared at a range of fO2s and temperatures. X-ray absorption near edge structure (XANES) spectroscopy of these glasses was carried out at the LIII-edge of these elements to determine their oxidation state ratios. Because of beam damage effects for the Eu-bearing glasses, a limited number of XANES spectra were recorded in situ at 1400 °C, and some samples were analysed by electron paramagnetic resonance spectroscopy. The results obtained were compared to trace element concentrations in zircons from some natural samples, and suggestions for future work made.
Relativistic scalar Aharonov-Bohm scattering
Creators: name: Gomes, M.
name: Malbouisson, J. M. C.
name: Rodrigues, A. G.
name: da Silva, A. J.
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We discuss the scattering of relativistic spin zero particles by an infinitely long and arbitrarily thin solenoid. The exact solution of the first-quantized problem can be obtained as a mimic of the nonrelativistic case, either in the original Aharonov-Bohm way or by using the Berry's magnetization scheme. The perturbative treatment is developed in the Feshbach-Villars two-component formalism for the Klein-Gordon equation and it is shown that it also requires renormalization as in the Schrodinger counterpart. The results are compared with those of the field theoretical approach which corresponds to the two-body sector of the scalar Chern-Simons theory.
description: 15 pages, Revtex
Implications of kHz Quasi-Periodic Brightness Oscillations in X--Ray Binaries for Neutron Star Structure
Creators: name: Thampan, A. V.
name: Bhattacharya, D.
name: Datta, B.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Kilohertz quasi-periodic oscillations (QPOs) in low-mass X-ray binaries (LMXBs) may represent the orbital frequencies of the innermost Keplerian orbits around accreting neutron stars. Attempts have recently been made to derive constraints on the mass and the equation of state of the neutron star, by identifying the highest observed QPO frequency with the Keplerian frequency at the marginally stable orbit given by the general theory of relativity. These estimates have either neglected the effect of neutron star rotation or used an approximate treatment of rotation in general relativity. We rederive these constraints using a fully general relativistic formalism including the effect of rapid rotation. We also present constraints corresponding to the case where the innermost stable orbit touches the stellar surface.
description: Replaced with new extensively revised version. To appear MNRAS, 302, L69
A characterization of generalized quaternion 2-groups
Creators: name: Tărnăuceanu, Marius
Publisher: name: arXiv
Year: 2018
Subjects: subject: Group Theory (math.GR)
subject: FOS: Mathematics

description: The goal of this note is to give a characterization of generalized quaternion $2$-groups by using their posets of cyclic subgroups.
Non-Supersymmetric SO(3)-Invariant Deformations of N=1* Vacua and their Dual String Theory Description
Creators: name: Zamora, Frederic
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the SO(3)-invariant relevant deformations of N=4 SU(N) gauge theory using the methods of Polchinski and Strassler. We present the region of parameter space where the non-supersymmetric vacuum is still described by stable ``dielectric'' five branes within the supergravity approximation.
description: 17 pages, 5 figures. LaTeX2e, utarticle.cls (included). v2: typos corrected, refs added
Additional file 1 of Genetic causal association between frozen shoulder and carpal tunnel syndrome: a two-sample mendelian randomization
Creators: name: Chen, Yang
name: Wu, Xiaojin
name: Zhang, Yongxing
name: Chen, Jian
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Supplementary Material 1
Diffeomorphism Invariant Integrable Field Theories and Hypersurface Motions in Riemannian Manifolds
Creators: name: Bordemann, Martin
name: Hoppe, Jens
Publisher: name: arXiv
Year: 1995
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We discuss hypersurface motions in Riemannian manifolds whose normal velocity is a function of the induced hypersurface volume element and derive a second order partial differential equation for the corresponding time function $τ(x)$ at which the hypersurface passes the point $x$. Equivalently, these motions may be described in a Hamiltonian formulation as the singlet sector of certain diffeomorphism invariant field theories. At least in some (infinite class of) cases, which could be viewed as a large-volume limit of Euclidean $M$-branesmoving in an arbitrary $M+1$-dimensional Riemannian manifold, the models are integrable: In the time-function formulation the equation becomes linear (with $τ(x)$ a harmonic function on the embedding Riemannian manifold). We explicitly compute solutions to the large volume limit of Euclidean membrane dynamics in $\Real^3$ by methods used in electrostatics and point out an additional gradient flow structure in $\Real^n$. In the Hamiltonian formulation we discover infinitely many hierarchies of integrable, multidimensional, $N$-component theories possessing infinitely many diffeomorphism invariant, Poisson commuting, conserved charges.
description: 15 pages, LATEX
Improving link prediction accuracy of network embedding algorithms via rich node attribute information
Creators: name: Gu, Weiwei
name: Hou, Jinqiang
name: Gu, Weiyi
Publisher: name: arXiv
Year: 2024
Subjects: subject: Social and Information Networks (cs.SI)
subject: FOS: Computer and information sciences

description: Complex networks are widely used to represent an abundance of real-world relations ranging from social networks to brain networks. Inferring missing links or predicting future ones based on the currently observed network is known as the link prediction task.Recent network embedding based link prediction algorithms have demonstrated ground-breaking performance on link prediction accuracy. Those algorithms usually apply node attributes as the initial feature input to accelerate the convergence speed during the training process. However, they do not take full advantage of node feature information. In this paper,besides applying feature attributes as the initial input, we make better utilization of node attribute information by building attributable networks and plugging attributable networks into some typical link prediction algorithms and naming this algorithm Attributive Graph Enhanced Embedding (AGEE). AGEE is able to automatically learn the weighting trades-off between the structure and the attributive networks. Numerical experiments show that AGEE can improve the link prediction accuracy by around 3% compared with link prediction framework SEAL, Variational Graph AutoEncoder (VGAE), and Node2vec.
Regulation of a biennial host plant population by an autoecious, demicyclic rust fungus: Puccinia hysterium on Tragopogon pratensis in the Park Grass Experiment
Creators: name: Salama, Nabeil Khairy Gad
Publisher: name: Imperial College London
Year: 2009

description: Models developed in continuous-time have been used to study the epidemiology and population dynamics of plant hosts, usually in cultivated systems. Here discrete-time SIR–type models are developed which contain parameters representing characteristics of an uncultivated, biennial host plant – systemic, castrating pathogen system. This thesis presents 4 epidemiological model forms representing a generic SIR model, a constant pathogen-induced mortality model, a variable pathogen-induced mortality model, and a model which has an additional phase representing a seedbank. Using a range of parameter values it is possible to produce simulation outcomes with population crashes, cycles and steady-state populations. For each of the models a pathogen epidemic criterion is derived as is a term describing population steady-state values. For the pathogen-induced mortality models, the invasion criteria include a pathogenicity term indicating that the pathogen in part regulates the host population dynamics. The biennial host plant Tragopogon pratensis has been recorded in the Park Grass Experiment and has been described as an outbreak species regulated by the autoecious, demicyclic rust fungus, Puccinia hysterium (Silvertown et al., 2006). The rust is shown to castrate the host plant by reducing the numbers of seed set and the viability of seeds produced by infected individuals. Further characteristics of this host – pathogen system are identified by using the developed models. This is justified as the recurrencerelationships derived from the models fit the observed data, and that the accuracy of the fit is increased with larger values of pathogen-induced mortality. These models produce simulation outcomes that are similar to the host population dynamics. The models also show that the system is governed by density-dependent factors.
An arithmetic method of counting the subgroups of a finite abelian group
Creators: name: Tărnăuceanu, Marius
Publisher: name: arXiv
Year: 2018
Subjects: subject: Group Theory (math.GR)
subject: FOS: Mathematics

description: The main goal of this paper is to apply the arithmetic method developed in our previous paper \cite{13} to determine the number of some types of subgroups of finite abelian groups.
title: ADCO, Grènetier de Cîteaux : comptes (1497-1504) (11 H 1172), f. 00245
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: comptes

description: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172), f. 00245, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Oral history interview with Nafis Sadik, 2002
Publisher: name: Columbia University
Year: 2020
Subjects: Population--Economic aspects
Economic development
Non-governmental organizations
Mothers--Mortality--Developing countries
Family planning--Political aspects
Population policy--Religious aspects
Women's health services
Human rights
Structural adjustment (Economic policy)

description: Early years: Raised in Calcutta; 1946 enters Calcutta Medical College; moved to Dehli, Pakistan; 1947 transfers to Dow Medical College Karachi; intern at Baltimore City Hospitals under Truman's Point IV program; 1951 graduates medical school. Career: Mid-1950's family planning for poor women in Abbotobad, Pakistan; studies public health at Johns Hopkins University through USAID grant; Planning Commission in Pakistan; 1965 Director of Family Planning in the Family Planning Council; 1971 hired at UN Population Fund (UNFPA); 1987 Executive-Director of UNFPA. Themes: population and development studies with NGOs and universities; first studies financed with UN on maternal mortality for World Health Organization (WHO); reduces maternal mortality and illegal abortions through family planning programs; conflict with US government; abortion and forced sterilization policies in China; first woman head of a UN organization; advocate of better organization, less fragmentation, and more transparency in UN; concerns about global, environmental over-consumption and population stabilization; struggle with Vatican over 1994 International Conference on Population and Development in Cairo; frames women's health as human rights issue at Cairo Conference; World Bank adjustment policies; gender dynamics in UN culture and research; believes individuals and outside agencies shape UN policy and reform
Additional file 1 of MSC-derived exosomes protect auditory hair cells from neomycin-induced damage via autophagy regulation
Creators: name: Liu, Huan
name: Kuang, Huijuan
name: Wang, Yiru
name: Bao, Lili
name: Cao, Wanxin
name: Yu, Lu
name: Qi, Meihao
name: Wang, Renfeng
name: Yang, Xiaoshan
name: Ye, Qingyuan
name: Ding, Feng
name: Ren, Lili
name: Liu, Siying
name: Ma, Furong
name: Liu, Shiyu
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Developmental Biology
subject: Cancer

description: Additional file 1: Figure S1. Exosomes derived from UC-MSCs increased hair cells survival after neomycin-induced damage in a dose-dependent manner. (A) Immunofluorescence staining with myo 7a (green), F-actin (red) and Hoechst (blue) in the apical, middle, and basal turn of cochleae after treated with exosome at different dose following neomycin damage. (B-D) Quantification of myo7a-positive hair cells per 100 μm in the apical(B), middle(C), and basal(D) turn of cochleae of different groups. Scale bar, 20 µm. The results were representative of the data generated in at least three independent experiments and presented as mean ± s.d. n.s., not significant; *P<0.05; **P<0.01 by one-way ANOVA (B-D). Figure S2. Inhibition of autophagy by knocking down Atg5 attenuated exosome-mediated otoprotection in HEI-OC1. HEI-OC1 were transfected with 60 nM negative control siRNA (Ctrl) or Atg5 siRNA (si-Atg5) for 48 h before neomycin exposure and/or exosome treatment (A) The expression levels of ATG5, LC3 and SQSTM1/p62 were evaluated by western blot and quantified by ImageJ software. (B) HEI-OC1 cells were labeled with Mito-SOX (red), and the relative fluorescence intensity was quantified after different treatments. Scale bar, 20 µm. (C) TUNEL and Hoechst double staining and (D) Cleaved CASP3 and Hoechst double staining were performed to detect the percentage of apoptotic HEI-OC1 cells after different treatments. Scale bar, 50 µm. (E) Cleaved CASP3 expression level was detected by western blot in HEI-OC1 cells treated with exosomes and/or Atg5 knockdown following neomycin insults and was quantified by ImageJ software. (F) Analysis of apoptotic HEI-OC1 cells by flow cytometry after different treatments. The results were representative of the data generated in at least three independent experiments. The data were presented as mean ± s.d. n.s., not significant; *P<0.05; **P<0.01 by Student’s t-test (A) or one-way ANOVA (B-F). Figure S3. The efficiency of endocytosis inhibition by Dynasore and Cytochalasin D. (A) Expression of CAV2 and EEA1 were detected by western blot after pre-treatment with dynasore (80 μM, 4 h) and cytochalasin D (2 μM, 30 min) and were quantified by ImageJ software. The results were representative of the data generated in at least three independent experiments. The data were presented as mean ± s.d. n.s., **P<0.01 by one-way ANOVA (A).
Tenthredo fasciata Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Tenthredinidae
Tenthredo
Tenthredo fasciata

description: Tenthredo fasciata [spec. nov.]
T. antennis clavatis nigris, abdomine glabro atro, alis superioribus fascia fusca.
Habitat in Europa.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 555, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Solitary quotients of finite groups
Creators: name: Tărnăuceanu, Marius
Publisher: name: arXiv
Year: 2018
Subjects: subject: Group Theory (math.GR)
subject: FOS: Mathematics

description: In this paper we introduce and study the lattice of normal subgroups of a group $G$ that determine solitary quotients. It is closely connected to the well-known lattice of solitary subgroups of $G$ (see \cite{5}). A precise description of this lattice is given for some particular classes of finite groups.
title: Ряды Фурье
title: Учебное пособие
titleType: Subtitle
Creators: name: Ильин М.Е.
Publisher: name: Вузовское образование
Year: 2019

description: В работе освещены вопросы, касающиеся построения и использования аппарата рядов Фурье и смежных разделов математики. Помимо теоретического материала, работа содержит примеры, поясняющие введенные понятия, и задачи для самостоятельного решения. Подготовлено в соответствии с Федеральным государственным образовательным стандартом высшего образования. Учебное пособие предназначено для студентов, обучающихся по направлениям 01.03.02 «Прикладная математика и информатика», 02.03.01 «Математика и компьютерные науки», 11.03.01 «Радиотехника», 11.03.02 «Инфокоммуникационные технологии и системы связи» и специальности 11.05.01 «Радиоэлектронные системы и комплексы», изучающих дисциплины «Численные методы», «Математические методы прогнозирования», «Уравнения математической физики», «Моделирование систем», «Цифровая обработка сигналов и сигнальные процессоры» и пр. Также может быть использовано студентами, магистрами и аспирантами, чьи научные интересы связаны с рядами Фурье.
LR Seimo politinė darbotvarkė per COVID-19 pandemiją ir vyriausybių kaita
Creators: name: Valentinavičius, Vytautas
Publisher: name: Zenodo
Year: 2021
Subjects: Politinė darbotvarkė
Seimo debatai
Žmogaus teisės
COVID-19 pandemija

description: Pranešimas nacionalinėje konferencijoje „Lietuva po 2020 m. Seimo rinkimų“, VU TSPMI, 2021 m. kovo 26 d.
Combination of pharmacotherapy and mechanical unloading for the treatment of chronic heart failure
Creators: name: Navaratnarajah, Manoraj
Publisher: name: Imperial College London
Year: 2013

description: Background: Left ventricular assist devices (LVAD) mechanically unload the failing left ventricle, and reverse heart failure-induced remodelling. However, achievement of clinical functional recovery remains rare (4-10%, “Bridge-to-recovery” (BTR)). Reasons for this disparity are unknown, but are likely due to detrimental changes caused by prolonged unloading. Pharmacological prevention of these changes has attracted considerable interest. This thesis aimed to test the central broad hypothesis that “mechanical unloading-induced reverse remodelling of whole heart / cellular structure and function in failing hearts, is improved by combination pharmacotherapy” and was tested using an animal model. Methods: Heart failure was induced by left coronary artery ligation (12 weeks) in male Lewis rats. Mechanical unloading was achieved by heterotopic abdominal heart transplantation (4 weeks). An array of techniques to study in vivo whole heart function, and structural and functional effects at the myocardial, cellular and molecular levels was used. The thesis firstly investigates the effects of clenbuterol, a drug used as part of the “Harefield Protocol” which enhanced functional recovery in patients with dilated cardiomyopathy, and then other novel pharmacological strategies: A) clenbuterol enantiomers (D / L) B) combined β2-AR agonism (clenbuterol) + β1-AR blockade (metoprolol) and C) If blockade (ivabradine), during prolonged mechanical unloading in the treatment of heart failure. Results: Treatment with clenbuterol or either of its enantiomers improves whole heart function of non-transplanted failing hearts. During mechanical unloading clenbuterol and its D-enantiomer enhance mechanical unloading-induced recovery of deranged cellular excitation-contraction coupling, but do not prevent myocardial atrophy. Chronic combined clenbuterol and metoprolol therapy, improves whole heart function of non-transplanted failing hearts in a synergistic manner. During mechanical unloading either clenbuterol, or metoprolol enhances mechanical unloading-induced recovery of deranged excitation-contraction coupling, but this enhancement is lost during combined drug therapy. Metoprolol alone prevented mechanical unloading-induced myocardial atrophy. Ivabradine therapy improves whole heart function and reverses myocardial fibrosis in non-transplanted failing hearts. During mechanical unloading ivabradine reverses myocardial fibrosis and enhances recovery of deranged excitation-contraction coupling. Conclusions: Manipulation of mechanical unloading-induced remodelling can be achieved by specific pharmacological therapy. The results presented here are relevant for the use of LVADs as treatment of heart failure and deserve to be tested in clinical trials.
A challenge in A(G)I, cybernetics revived in the Ouroboros Model as one algorithm for all thinking
Creators: name: Thomsen, Knud
Publisher: name: arXiv
Year: 2024
Subjects: subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences
subject: I.2.0; I.2.4
subject: 93-08

description: A topical challenge for algorithms in general and for automatic image categorization and generation in particular is presented in the form of a drawing for AI to understand. In a second vein, AI is challenged to produce something similar from verbal description. The aim of the paper is to highlight strengths and deficiencies of current Artificial Intelligence approaches while coarsely sketching a way forward. A general lack of encompassing symbol-embedding and (not only) -grounding in some bodily basis is made responsible for current deficiencies. A concomitant dearth of hierarchical organization of concepts follows suite. As a remedy for these shortcomings, it is proposed to take a wide step back and to newly incorporate aspects of cybernetics and analog control processes. It is claimed that a promising overarching perspective is provided by the Ouroboros Model with a valid and versatile algorithmic backbone for general cognition at all accessible levels of abstraction and capabilities. Reality, rules, truth, and Free Will are all useful abstractions according to the Ouroboros Model. Logic deduction as well as intuitive guesses are claimed as produced on the basis of one compartmentalized memory for schemata and a pattern-matching, i.e., monitoring process termed consumption analysis. The latter directs attention on short (attention proper) and also on long times scales (emotional biases). In this cybernetic approach, discrepancies between expectations and actual activations (e.g., sensory precepts) drive the general process of cognition and at the same time steer the storage of new and adapted memory entries. Dedicated structures in the human brain work in concert according to this scheme.
description: 26 pages, 11 figures
Neonatal Nav1.5 voltage-gated Na+ channel : regulation, electrophysiology and pharmacology
Creators: name: Onkal, Rustem
Publisher: name: Imperial College London
Year: 2011

description: The overall aims of this PhD were (1) to evaluate the mechanisms controlling functional expression of neonatal Nav1.5 (nNav1.5), the predominant voltage-gated sodium channel (VGSC) subtype expressed in metastatic human breast cancer (BCa) cells, and (2) to characterize the electrophysiological and pharmacological properties of nNav1.5 compared with the adult Nav1.5 (aNav1.5) counterpart. Experiments were carried out under normoxic and hypoxic conditions. The Results chapter-1 demonstrates the hypoxic upregulation of functional VGSC (nNav1.5) expression in MDA-MB-231 human BCa cells, proposed to occur via positive feedback involving Na+ influx and activation of protein kinase A. Upregulation of nNav1.5, evident at mRNA, protein and signalling levels, led to significant augmentation of Matrigel invasion. The hypoxia-sensitive persistent Na+ current (INaP) played a significant role in the increased invasiveness. The Results chapter-2 shows that, compared to aNav1.5, nNav1.5 (i) exhibited depolarized activation, (ii) had slower activation/inactivation kinetics, (iii) allowed greater transient charge (Na+) influx, (iv) recovered from inactivation significantly more slowly, (v) exhibited greater use-dependent attenuation, and (vi) expressed larger INaP. Mutagenesis studies revealed the charge-reversing Asp211 (aNav1.5) to Lys211 (nNav1.5) switch to be predominantly responsible for these differences. Surprisingly, however, challenging the two splice variants with mono-, di- and trivalent cations generated only subtle differential effects in channel gating. The Results chapter-3 determines the sensitivities of nNav1.5 and aNav1.5 to various VGSC blockers. The effects of small-molecule drugs lidocaine, phenytoin, mexiletine, procaine, ranolazine and riluzole were similar. NESOpAb, a polyclonal antibody targeting nNav1.5, exhibited ~200-fold lower threshold and ~5-fold lower IC50 for inhibiting nNav1.5 vs. aNav1.5; the Lys/Asp211 residue was crucial to this difference. Spider toxins ProTx-II and HaTx were found to share a binding site in the nNav1.5/aNav1.5 splicing region, exhibiting ~25- and 5-fold selectivity for aNav1.5. Each Results chapter ends with a discussion and highlighting of clinical implications.
title: ADCO, Cartulaire des Dominicains de Dijon (1286), Cart. 221 (H 53), 170 folios, f. 0027
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire des Dominicains de Dijon (1286), Archives départementales de la Côte-d'Or, Cart. 221 (H 53), 170 folios. Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire des Dominicains de Dijon (1286), Archives départementales de la Côte-d'Or, Cart. 221 (H 53), 170 folios, f. 0027, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb15250518p
description: Provenance: http://www.idref.fr/02643413X/id
description: Provenance: https://www.geonames.org/6453767
description: Provenance: Dijon
description: Provenance: http://www.wikidata.org/entity/Q7003
Legionella pneumophila pathogenesis : establishment of a new insect infection model and characterisation of the effector protein LtpD
Creators: name: Harding, Clare R.
Publisher: name: Imperial College London
Year: 2013

description: Legionella pneumophila is the causative agent of Legionnaires’ disease, severe pneumonia acquired from inhalation of contaminated water droplets. In the lung, L. pneumophila infects alveolar macrophages and creates a compartment named the Legionella containing vacuole (LCV), which avoids degradation and recruits components of the secretory pathway. LCV creation depends on the action of the Dot/Icm system that translocates over 275 effectors into the host cell. To study the function of these effectors, models that approximate human disease are required. Here, I characterise the larvae of Galleria mellonella as an infection model for L. pneumophila. Infection resulted in larval mortality and bacterial replication in a strain- and Dot/Icm-dependent manner. Flagella expression was dispensable for bacterial virulence, however secreted phospholipases and the Dot/Icm effector SdhA were shown to be important in virulence. Deletion of SdhA resulted in disruption of the LCV membrane and destruction of haemocytes. The importance of SdhA expression was confirmed in a mammalian model, validating the utility of G. mellonella. In the second part of this study, the novel protein LtpD was characterised. LtpD was translocated via the Dot/Icm secretion system and localised to the LCV. A series of truncation mutants defined a C-terminal 153 amino acid domain as required for LCV localisation. This region was shown to bind directly to the lipid phosphoinositide 3-phosphate. Further analysis revealed that LtpD also interacted with the enzyme inositol monophosphatase 1, however did not change the enzyme’s activity in vitro. Deletion of LtpD resulted in a subtle growth defect in mammalian macrophages at late time points during infection. This growth defect was also seen the G. mellonella and mouse lungs, confirming that LtpD is a virulence factor of L. pneumophila. In summary, here I present an infection model to investigate L. pneumophila virulence and further characterisation of the Dot/Icm effector LtpD.
$Q$-curvature and gravity
Creators: name: Chernicoff, M.
name: Giribet, G.
name: Grandi, N. E.
name: Lavia, E. F.
name: Oliva, J.
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: In this paper, we consider a family of $n$-dimensional, higher-curvature theories of gravity whose action is given by a series of dimensionally extended conformal invariants. The latter correspond to higher-order generalizations of the Branson $Q$-curvature, which is an important notion of conformal geometry that has been recently considered in physics in different contexts. The family of theories we study here includes special cases of conformal invariant theories in even dimensions. We study different aspects of these theories and their relation to other higher-curvature theories present in the literature.
description: 19 pages, no figures
Chronic thromboembolic pulmonary vascular disease: physiological concepts and genetic predisposition
Creators: name: McCabe, Colm
Publisher: name: Imperial College London
Year: 2014

description: Chronic thromboembolic pulmonary hypertension (CTEPH) is an uncommon sequela of acute pulmonary embolism and, untreated, leads to right ventricular (RV) failure and death. Despite its growing recognition, methods for the detection of early RV insufficiency and prediction of clinical deterioration, important to optimum preservation of RV function, are currently suboptimal. Furthermore, underlying genetic predisposition to CTEPH, unexplained by defective fibrinolysis, remains largely unexplored. The RV’s physiological response to chronic thromboembolic obstruction is arguably best described by RV pressure volume loops which, historically, are best obtained using the conductance catheter. Although invasive, conductance has an indisputable advantage over current imaging modalities; catheters measure dynamic ventricular pressure and volume throughout the cardiac cycle. Using this technique, abnormal RV pressure volume loops are demonstrated in response to chronic thrombotic obstruction, independent of resting haemodynamic criteria diagnostic of CTEPH. Pressure volume differences and accrual of an exercise gas exchange deficit further suggest early ‘subclinical’ RV adaptation. The genetic architecture of CTEPH is also explored using high-throughput sequencing of unrelated patients. This shows that rare DNA variants in CTEPH that are predicted to harbour deleterious effects are not over-represented in fibrinolytic pathways. Finally, prognostication in CTEPH is evaluated using a clinical deterioration model which is shown to be predicted by patient-reported outcomes at diagnosis. In conclusion, RV and pulmonary circulatory function in chronic thromboembolic pulmonary vascular disease are inadequately characterised by existing routine methods. Links between the observed physiological deficits, risk of clinical deterioration and abnormal genetic architecture warrant further evaluation in this rare disease.
Chemical Vapour Deposition of Large-area High-quality Graphene Films for Electronic Applications
Creators: name: Wang, Kai
Publisher: name: Imperial College London
Year: 2014

description: Low Pressure Chemical Vapour Deposition (LPCVD) and transfer processes are explored and optimized to obtain large-area, continuous and high quality monolayer graphene on target substrate. The size of synthesized graphene reaches up to 20 mm * 20 mm, and can be further extended by upgrading to a larger reaction chamber; the monolayer coverage rate and conductivity is better than normal commercial graphene products on the market. A novel frame-assisted method is developed to transfer graphene without introducing many defects and impurities. Annealing and acetone treatment are combined to remove PMMA residues effectively and unharmfully. A new under-etching route to fabricate graphene free-standing structure is also proposed and explored. A novel non-contact microwave examination method has been employed to simplify the sheet resistance measurement processes and to avoid the effects of metallic contacts. This method is simple and non-destructive to graphene, and can be further integrated into the graphene production line in the future. A new double-layer device is fabricated and utilized to observe the microwave field effect in graphene. The interaction between graphene and oxygen under different temperatures and oxygen partial pressures is studied and discussed. Strontium Titanate films (SrTiO3 or STO) are deposited on transferred CVD grown graphene on MgO substrates. Based on the oxidation test result, the deposition process of Strontium Titanate is optimized to minimize the defects introduced on graphene. Raman mapping data show that graphene is still continuous after the STO deposition although the D band suggests some newly formed defects.
Pulsar Scintillation and the Local Bubble
Creators: name: Bhat, N. D. Ramesh
name: Gupta, Yashwant
name: Rao, A. Pramesh
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present here the results from an extensive scintillation study of twenty pulsars in the dispersion measure (DM) range 3 - 35 pc cm^-3 caried out using the Ooty Radio Telescope (ORT) at 327 MHz, to investigate the distribution of ionized material in the local interstellar medium. Observations were made during the period January 1993 to August 1995, in which the dynamic scintillation spectra of these pulsars were regularly monitored over 10 - 90 epochs spanning 100 days. Reliable and accurate estimates of strengths of scattering have been deduced from the scintillation parameters averaged out for their long-term fluctuations arising from refractive scintillation (RISS) effects. Our analysis reveals several anomalies in the scattering strength, which suggest tht the distribution of scattering material in the Solar neighborhood is not uniform. We have modelled these anomalous scattering effects in terms of inhomogeneities in the distribution of electron dnsity fluctuations in the local interstellar medium (LISM). Our model suggests the presence of a low density bubble surrounded by a shell of much higher density fluctuations. We are able to put constraints on geometrical and scattering properties of such a structure, and find it to be morphologically similar to the Local Bubble known from other studies.
description: 35 pages, 12 figures
Materials, Processes, and (infra)Structures for the Ecological Transition: an opportunity for poro-science and engineering
Creators: name: biot-bazant, figshare admin
name: Damme, Henri Van
Publisher: name: The Biot-Bazant Conference
Year: 2021
Subjects: subject: 90506 Structural Engineering
subject: FOS: Civil engineering
subject: 91402 Geomechanics and Resources Geotechnical Engineering
subject: FOS: Environmental engineering

description: This publication is part of the proceedings of the Biot-Bažant Conference on Engineering Mechanics and Physics of Porous Materials, which took place virtually on June 1-3, 2021. It contains a one-page abstract and the video of the talk that was given at the conference.
Swift UVOT Grism Observations of Nearby Type Ia Supernovae - I. Observations and Data Reduction
Creators: name: Pan, Y. -C.
name: Foley, R. J.
name: Filippenko, A. V.
name: Kuin, N. P. M.
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Ultraviolet (UV) observations of Type Ia supernovae (SNe Ia) are useful tools for understanding progenitor systems and explosion physics. In particular, UV spectra of SNe Ia, which probe the outermost layers, are strongly affected by the progenitor metallicity. In this work, we present 120 Neil Gehrels Swift Observatory UV spectra of 39 nearby SNe Ia. This sample is the largest UV (lambda < 2900 A) spectroscopic sample of SNe Ia to date, doubling the number of UV spectra and tripling the number of SNe with UV spectra. The sample spans nearly the full range of SN Ia light-curve shapes (delta m(B) ~ 0.6-1.8 mag). The fast turnaround of Swift allows us to obtain UV spectra at very early times, with 13 out of 39 SNe having their first spectra observed >~ 1 week before peak brightness and the earliest epoch being 16.5 days before peak brightness. The slitless design of the Swift UV grism complicates the data reduction, which requires separating SN light from underlying host-galaxy light and occasional overlapping stellar light. We present a new data-reduction procedure to mitigate these issues, producing spectra that are significantly improved over those of standard methods. For a subset of the spectra we have nearly simultaneous Hubble Space Telescope UV spectra; the Swift spectra are consistent with these comparison data.
description: Accepted for publication in MNRAS
Brane Potentials and Moduli Spaces
Creators: name: Papadopoulos, George
name: Tong, David
Publisher: name: arXiv
Year: 2000
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: It is shown that the supergravity moduli spaces of D1-D5 and D2-D6 brane systems coincide with those of the Coulomb branches of the associated non-abelian gauge theories. We further discuss situations in which worldvolume brane actions include a potential term generated by probing certain supergravity backgrounds. We find that in many cases, the appearance of the potential is due to the application of the Scherk-Schwarz mechanism. We give some examples and discuss the existence of novel supersymmetric brane configurations.
description: 26 pages, phyzzx.tex