cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Maternal docosahexanoic acid supplementation increases adiponectin expression in intrauterine growth restricted rats
Creators: name: Bagley, Heidi
Publisher: name: University of Utah
Year: 2012
Subjects: Adiponectin
Docosahexanoic acid
Intrauterine growth restriction
Type 2 diabetes
Fetal growth retardation
Animal models
Rats

description: Intrauterine growth restriction (IUGR) increases the risk of obesity and insulin resistance in adulthood. Insulin resistance is inversely correlated with serum adiponectin levels. Adiponectin expression increases with PPAR? activation by docosahexanoic acid (DHA). We have previously shown that IUGR results in PPAR? dysregulation in adipose tissue before the onset of obesity and that its expression can be normalized by maternal DHA administration.  However, the effect of IUGR and PPAR? activation on adiponectin production in the rat is unknown. We hypothesize that adding DHA to the maternal diet will increase subcutaneous adipose tissue (SAT) adiponectin and adiponectin receptor mRNA and protein and serum adiponectin.  IUGR was induced by bilateral uterine artery ligation at E19 of gestation. Maternal rats were fed a standard diet or a 1% DHA diet from E13 to term and during lactation. The effect of IUGR on mRNA levels of adiponectin and its receptors (AdipoR1 and AdipoR2) in SAT and visceral adipose tissue (VAT) of d21 rats was measured by real-time RT-PCR. Serum adiponectin levels were measured by ELISA. Protein levels were measure by western blotting.  In regular diet rats, IUGR significantly increased mRNA levels of AdipoR1 in VAT and AdipoR2 in SAT of males. DHA supplementation on IUGR significantly increased mRNA levels of adiponectin (236±16%*), AdipoR1 (189±15%*), and Adipor2 (384± 65%*) in male SAT and adiponectin (199±16%*) and AdipoR2 (425±23%*) in female SAT. AdipoR1and R2 protein levels were increased in male (220±38%; 255±51%*) and female (202±19%*; 229±22%) SAT. Serum adiponectin levels were increased in males (149±13%*) and females (156±11%*). *p<0.05  We conclude that IUGR results in an altered expression of adiponectin and its receptors. Maternal DHA supplementation increases SAT adiponectin, AdipoR1/2 mRNA and protein, and serum adiponectin levels in IUGR rats. We speculate that increased adiponectin production in DHA supplemented IUGR rats may protect against the development of insulin resistance in adulthood.
A comparison of organized, team based, intravenous therapy with conventional care methods.
Creators: name: Bair, Jan Nelson
Publisher: name: University of Utah
Year: 2012
Subjects: Pharmaceuticals
Nursing Team

description: The objectives of this investigation were to determine the incidence of various complications of infusion therapy in patients treated by a trained intravenous therapy team as compared to those which occurred when the conventional approach of disseminated professional personnel was utilized.  Specific anatomical sites of venipuncture as well as specific indwelling intravenous devices were compared in order to identify possible contributing factors to infusion complications.  A single-blind study of 204 randomly selected patients receiving intravenous therapy is presented, and the observed infusion complications are statistically analyzed.  The surface topography of seven sample catheters was observed, and twenty-seven scanning electron micrographs are shown as representative of the analyses.  Significantly fewer thrombophlebitis infusion complications were observed in those patients cared for by the intravenous therapy team than in patients cared for by other individual professional groups.  Observations of the Desert Pharmaceutical Company's Augiocath catheter showed significantly fewer thrombophlebitis complications for all catheter sizes used, however, the 22-gauge size produced significantly more solution infiltration complications.  Total complications versus total venipunctures utilizing catheters showed no significant differences among the four manufactures.  The major conclusions were:  (1) The use of a trained team of registered nurses in the provision of intravenous therapy significantly reduces the rates of infusion complications in the patient population.  (2) All observed catheters had a relatively low level of resistance to thrombus adherence.
Brief an [Johann III Bernoulli]
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1784

description: von A. Schroeder
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Druck: Johann Bernoulli's Sammlung kurzer Reisebeschreibungen und anderer zur Erweiterung der Länder- und Menschenkenntniss dienender Nachrichten. - Berlin : bey dem Herausgeber, ; Leipzig : in der Buchhandlung der Gelehrten, 1784, 13, S.438
description: Verzeichnung=Description=Inventaire April 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Improved method of isolating brucellosis organisms from blood clots utilizing the membrane filter
Creators: name: Callister, Dale Taft
Publisher: name: University of Utah
Year: 2012
Subjects: Isolation and Purification

description: The Millipore type of membrane filter was used to culture a Brucella abortus species from artificailly infected rabbit blood clots. Attempts were made to isolate naturally occurring species of these organisms from both human and animal bloods on this filter. The blood clots were treated with both physical and enzymatic methods in an attempt to prepare a liquid that would pass through the membrane filter. The results of blood degradation with distilled water, dilute acids and sand-glass beads-distilled water were found to be poor when attempts were made to filter the supernatants prepared by these methods. There was no reisolation when the clot was artifically inoculated with Brucella species when treated by physical and chemical methods. The use of fibrinolysin (streptokinase) to dissolve the rabbit blood clots produced excellent results. Both the digestion of the clot and the production of a filterable supernatant that would pass through the membrane were obtained. Recovery of the Brucella species artificially inoculated into these enzymatically treated clots was made. No positive isolations of Brucella species were made when this streptokinase Brucella isolation technique was applied to unknown animal and human bloods suspected of harboring this organism. A variety of organisms were islated, most of which were probably contaminants introduced inot the blood before being received at this laboratory.
The effect of intrauterine growth restriction on the expression of the PPAR? target gene, SETD8 in adipose and liver of the rat
Creators: name: Bailey, Ornela Bashaj
Publisher: name: University of Utah
Year: 2012
Subjects: IUGR
PPAR gamma
SETD8
Intrauterine growth restriction
Obesity
Fetal growth retardation
Rat
Adipose dysfunction

description: Intrauterine growth restricted (IUGR) born individuals are at a higher risk for developing obesity and associated co-morbidities in adulthood. An underlying  component of these morbidities is adipose dysfunction, with the accumulation of visceral adipose tissue (VAT) in conjunction with an increased expression of peroxisome  proliferator activated receptor gamma PPAR?, a proadipogenic factor. Interestingly, in hepatic tissue of the adolescent IUGR female, PPAR? expression displays a decreasing trend. PPAR?'s actions may be mediated by set domain containing histone methyltransferase Setd8 an epigenetic modification enzyme, and direct transcriptional target of PPAR?. In this study, we hypothesize that IUGR will affect mRNA and protein  levels of Setd8 in a gender and tissue specific manner in visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and hepatic depots before the onset of metabolic disease in postnatal day 21 rats. Uteroplacental insufficiency (UPI) induced IUGR day  21 adipose (SAT and VAT), and hepatic tissue was compared to control tissue using real time RT PCR for mRNA and western blotting for protein levels of Setd8. IUGR increased Setd8 protein levels in visceral adipose tissue of males of and decreased Setd8 protein levels hepatic tissue of females. IUGR did not have a significant effect on SAT mRNA and protein levels. This study demonstrates that IUGR alters Setd8 expression in  day 21 rat in a gender and tissue specific manner, consistent with previously observed changes in PPAR? expression, before the onset of metabolic disease and obesity. We speculate that IUGR alters epigenetic gene regulation in adipose and liver, PPAR? and its target enzyme Setd8, and that this may contribute to adult onset obesity observed in this population.
El uso de espejos para la creación de ilusiones ópticas y su influencia en instalaciones artísticas del S.XXI.
Creators: name: Rodríguez Jiménez, María del Carmen
name: Pérez González, Carmen
name: de Iracheta Martín, María
Publisher: name: Zenodo
Year: 2023
Subjects: espejos
mirada múltiple
ilusiones ópticas
obras artísticas instalativas

description: En este póster resume cómo se enfoca en el uso de espejos para crear ilusiones ópticas en obras artísticas instalativas en el siglo XXI. La investigación explora cómo los espejos pueden generar engaños perceptivos y crear ambientes ambiguos entre la realidad y la representación, lo que permite la construcción de no-lugares. Además, se estudia cómo estas ilusiones pueden incitar al público a una participación activa a través de lo que se denomina la "mirada múltiple".
Cytotoxic potential of three Sabal species grown in Egypt: a metabolomic and docking-based study
Creators: name: El-Hawwary, Seham S.
name: Saber, Fatema R.
name: Almaksoud, Hanan M. Abd
name: Elimam, Hanan
name: Sayed, Ahmed M.
name: Abdelmohsen, Usama Ramadan
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology

description: The phytochemical profiles of leaves and pollen grains’ extracts of S. causiarum, S. palmetto and S. yapa were investigated and characterised by LC-HR-MS-based metabolomic analysis. Further, biomarker metabolites were determined using multivariate and clustering analysis. S. causiarum leaves extract along with both S. palmetto and S. yapa pollen grains extracts showed interesting in vitro cytotoxic activity using MTT assay against PC-3 cell lines. While, both S. yapa leaves and pollen grains-derived extracts and S. causiarum pollen grains-derived extracts were active against A-172 cell line. OPLS-DA models was generated, to putatively determine the most active cytotoxic metabolites, these models suggested that alkaloids, flavonoids and phenolic acids are the most important metabolites in the active extracts. In silico analysis (neural-networking-based activity prediction and docking studies) of these top-scoring metabolites further supported OPLS-DA models predictability. This study could be considered as primary step in the in-depth exploration of bioactive natural products from Sabal.
Risk Differentiation for Critical Infrastructure Protection
Creators: name: Meng, Sascha
name: Wiens, Marcus
name: Schultmann, Frank
Publisher: name: Karlsruhe
Year: 2014
Subjects: critical infrastructure protection
safety-relevant risks
security-relevant risks

description: Critical infrastructures, e.g., electricity transmission / distribution, public transport and health care systems, need to be protected against various internal and external risks which can be safety- and / or security-relevant. Predominately probability-based methods are hitherto used for analysing the whole spectrum of risks. We think this is an insufficient approach, presumably leading to inefficient resource allocation and biased risk perception, as it does not consider the different natures of risk. This paper looks at the key difference between safety- and security-relevant risks, highlights resulting implications for critical infrastructure protection and describes a possible approach for handling these different types of risk.
DIGITAL CRISIS: AN IN-DEPTH EXPLORATION OF THE DILEMMA OF DOCUMENTRY ONTOLOGY
Creators: name: Dr. ZHANG XIONG
name: Dr. ZHANG HUAJUN
name: CHANG RUI
Publisher: name: Zenodo
Year: 2024
Subjects: Documentary, Digital technology, Ontology Dilemma, Fracture Crisis.

description: Abstract

The ontology of documentary pursues the expression of authenticity, constructs an index relationship corresponding to the real life of objective society, and reveals the truth and truth hidden under the surface of things. However, this paradigm has encountered a major crisis in the digital age, mainly because digital technology has enabled documentary images to point to the correspondence between symbols and objects that objectively exist, and has been completely deconstructed. Documentary is mired in the digital crisis of "fracture" in terms of material source, picture arrangement, and acceptance to the audience, and many theoretical researchers have fiercely criticized the authenticity paradigm of documentary ontology. However, digital technology itself has its own unsolvable limitations, human beings have the instinct to pursue objective reality, and fiction can also serve the truth, which makes documentary still stick to its own ontological bottom line in the digital age, without abandoning their authentic nature. The ontological dilemma of documentary in the digital age can actually be solved.
Phytochemical constituents and anti-tyrosinase activity of Macadamia integrifolia leaves extract
Creators: name: Hawary, Seham S. El
name: Abubaker, Mohammed
name: El-Kader, Essam M. Abd
name: Mahrous, Engy A.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: Macadamia integrifolia Maiden & Betche is cultivated around the world for its highly valued nuts (macadamia nuts). Although the chemical composition of the edible macadamia oil has been repeatedly investigated, other plant organs have not been phytochemically or biologically assessed. In this study, ethanolic extract of M. integrifolia leaves was phytochemically investigated which led to the isolation of 6 compounds. Two functional galactolipids, i.e., monogalactosyl diacylglycrol 36:4 (MGDG 36:4), digalactosyl monoacylglycerol 18:2 (DGMG 18:2), gallic acid and protocatechuic acid were identified in the genus Macadamia for the first time, in addition to the cyanogenic glycoside dhurrin and β-sitosterol. Additionally, anti-tyrosinase activity of the extract, its fractions and isolated compounds was investigated and a good tyrosinase inhibitory activity was observed for the extract, IC50=85 µg/mL and its polar fractions (ethyl acetate at 60 µg/mL and n-butanol at 75 µg/mL), with gallic acid showing strong anti-tyrosinase activity at IC50 56 µg/mL.
The antioxidant activities of flavonoids in Jerusalem artichoke (Helianthus tuberosus L.) leaves and their quantitative analysis
Creators: name: Wang, Ming-Yang
name: Ma, Zhi-Li
name: He, Cheng-Li
name: Yuan, Xiao-Yan
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified

description: The main targets of this work were to evaluate the antioxidative properties of flavonoids in Jerusalem artichoke (Helianthus tuberosus L.) leaves and quantitatively determine their contents. 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2-azino-bis (3-ethylbenzothiazoline)-6-sulphonic acid (ABTS) and hydroxyl free radicals scavenging assays were performed to determine their antioxidative capacities. The validated ultra high-performance liquid chromatography-quadrupole-time-of-flight/mass spectrometry (UHPLC-Q-TOF/MS) method was subsequently applied to the quality evaluation of eleven batches of Jerusalem artichoke leaves grown in different habitats at different harvesting time. Results indicated that two flavonoids isolated from Jerusalem artichoke leaves showed stronger antioxidant effects than the positive control, butylated hydroxytoluene (BHT). And the total contents of the two flavonoids in the Jerusalem artichoke leaves of flowering stage from Dalian, Liaoning Province, China, were the highest, their contents varied significantly depending on region and harvesting time. This study indicated that the leaves of Jerusalem artichoke possessed excellent antioxidant properties, highlighting their candidacy as natural antioxidants, which could be utilized therapeutically to protect the body from diseases caused by oxidative stress.
Dysregulation of retinoid biosynthesis and metabolism during colon carcinogenesis
Creators: name: Sandoval, Imelda Tumanan
Publisher: name: University of Utah
Year: 2012
Subjects: Colon
Retinoids

description: The research work presented in this dissertation describes the dysregulation of the retinoid biosynthetic and metabolic pathways accompanying colon carcinogenesis. Colon cancer remains the third leading cause of cancer deaths in the United States. A better understanding of the molecular mechanisms underlying colon tumorigenesis is needed to develop more effective therapies against colon cancer. Chapter 1 is an introduction on colon cancer and retinoids. The relationship between normal intestinal development and progression of colon cancer, including a background on adenomatous polyposis coli (APC) and several colorectal cancer syndromes are presented in the first half of Chapter 1. The latter part is a discussion of retinoid storage, biosynthesis and metabolism. It also summarizes what has been reported about the role of retinoids in normal colon function and their therapeutic effects on various human tumors. Retinol dehydrogenase like (DHRS9) is a colon-specific retinol dehydrogenase that is down-regulated in colon carcinomas. Chapter 2 describes studies that were undertaken to confirm the retinol dehydrogenase activity of DHRS9, demonstrate impairment of the retinoid biosynthetic capabilities of colon carcinoma cells and investigate the possible control of retinoic acid biosynthesis by APC through regulation of DHRS9 expression. A brief description of the retinol dehydrogenase activity of three zebrafish retinol dehydrogenases---rdh1, rdh1l and rdh5, is presented in Chapter 3. A discussion on the regulation of retinoid biosynthesis by APC and the importance of retinoic acid in zebrafish eye and gut development is also included. This is followed by Chapter 4, which describes significant differences in the dysregulation of the retinoid biosynthetic pathway in human colon carcinomas compared to the Apc[min/+ mouse, an established animal model system for studying colon cancer. Chapter 5 shows that the dysregulation of retinoid biosynthesis at multiple points along the pathway is a common occurrence in human colon carcinomas and colon carcinoma cell lines. Studies on cellular retinol binding protein II (CRBPII), its importance in normal intestinal development and retinol uptake are presented as well. Chapter 5 also discusses a broader role for APC in regulating intestinal differentiation by controlling several retinoid biosynthetic components. Conclusions and implications of presented findings are discussed in Chapter 6.
1 Brief an Regula Meyer [von Knonau-]Lavater
Creators: name: Lavater, Johann Caspar
Publisher: name: [s.n.]
Year: 1800

description: von Johann Caspar Lavater
description: Dabei Notiz auf separatem Zettel: "dieß erst nach Lavaters Tod (als Vermächtniß von ihm) erhalten"
MYC deficiency impairs the development of effector/memory T lymphocytes
Creators: name: , Nozais
Publisher: name: Zenodo
Year: 2022

description: This poster was presented at JOBIM (And was supported by a grant from Société Française de Bioinformatique) conference in France in July 2022 and is linked to this paper : https://doi.org/10.1016/j.isci.2021.102761
Cytotoxic and anti-diabetic potential, metabolic profiling and insilico studies of Syzygium cumini (L.) Skeels belonging to family Myrtaceae
Creators: name: Elhawary, Seham Salah Eldin
name: Elmotyam, Amira kamal Eldin
name: Alsayed, Doaa kamel
name: Zahran, Eman Maher
name: Fouad, Merivat Ahmed
name: Sleem, Amany Ameen
name: Elimam, Hanan
name: Rashed, Mohamed H.
name: Hayallah, Alaa M.
name: Mohammed, Anber F.
name: Abdelmohsen, Usama Ramadan
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: LC-HR-MS-coupled metabolic profiling of the methanol extracts from different parts of Syzygium cumini (L.), which was extensively identified via DNA fingerprinting, led to dereplication of 24 compounds. Cytotoxic investigation highlighted both extracts as the most potent, against both MCF-7 and MDA-231 Cell lines, with IC50 value of 5.86 ± 0.63 µg/ml and against HCT −116 cell line, with IC50 value of 1.24 ± 0.09 µg/ml, respectively. A molecular docking study was performed on the dereplicated compounds, which highlighted myricetin-3-glucoside (7), myricitrin (12), reynoutrin (15) and quercitrin (16) as the top scoring ligands within the protein active site (FIH-1). Interestingly, the extracts were significant against streptozotocin-induced diabetes in the order of flowers > seeds > leaves with BGL level of 98.9 ± 4.3, 123.2 ± 4.9 and 132.8 ± 5.9 mg/dl, respectively. The study highlights the health benefits of Syzygium cumini (L.) as a promising cytotoxic source.
Exploring process towards realism: Dogme Interactive Film Archive.
Creators: name: Newman, Thomas
Publisher: name: University of Utah
Year: 2012
Subjects: Motion pictures
Archives
Designs
Plans

description: From the Project summary: "Architecture has historically been an art form that seeks meaning throughout the universe. From the Primitive Hut, throughout the myriad of styles and movements leading to contemporary architecture, and ultimately the path for the future, architectural design looks for inspiration in the human relationship to the environment, to the universe, and to culture. The human element defines the essence of realism in architecture. This project explores a design approach to architectural realism, inspired by Dogme 95, a process oriented approach to film making. Filmic realism is chosen as a source for architectural inspiration because of its inherent notion of "truth" within the projection of experiential sequences of the human relationship to space. Programmatically, this project is an interactive film archive for the preservation of films related to Dogme 95. This interaction incorporates a myriad of users in the spectrum of general public to professional filmmaker. This project embodies Dogme as program, while projecting a design process inspired by the movement."
1 Stammbuchblatt an [N.N.]
Creators: name: Lavater, Johann Caspar
Publisher: name: [s.n.]
Year: 1786

description: von J[ohann] C[aspar] Lavater
description: Dabei "Persiflage auf Lavater, als er Bremen im Jahre 1786 besucht hatte. (Aus Oeser's Nachlaß.)"
Oncostatin M: origins of a pleiotropic cytokine.
Creators: name: Dahms, Kimberly Mae
Publisher: name: University of Utah
Year: 2012
Subjects: Oncostatin M
Pletropic
Cytokine

description: Cytokines comprise the molecular communication networks that allow cells to respond to their environments. Oncostatin M belongs to the interleukin-6 family of cytokines and has diverse effects on many different cell types. In various model systems, it has been shown to influence cell cycle progression, developmental regulation, and the inflammatory process. Therefore, it is difficult to classify oncostatin M as one type of effector molecule. The origins and regulation of oncostatin M expression have not been extensively examined. The goal of this dissertation was to identify and characterize oncostatin M expression in normal human tissues. Primary human monocytes secrete oncostatin M following activation with cytokines or bacterial components. Agonist treatment of monocytes results in activation of the Janus-kinase signal transducer and activator of transcription (JAK-STAT) pathway. Specifically, STAT5b was found to bind and activate the oncostatin M promoter at a STAT binding site located -180 base pairs before the transcriptional start site. In addition, oncostatin M was produced by epithelial cells as indicated by immunohistochemistry and in situ hybridization. In contrast to monocytes, primary epithelial cells appeared to synthesize oncostatin M constitutively. Oncostatin M expression was detected only in primary cells, not in transformed cell lines. This would suggest, with previous reports, that a lack of oncostatin M expression is associated with the transformed phenotype. In summary, the origins of oncostatin M in the normal human system were found to be activated monocytes, which synthesize oncostatin M following activation, and specific types of epithelial cells, which synthesize oncostatin M constitutively.
Trizogeniates Ohaus 1917
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Rutelidae
Trizogeniates

description: TRIZOGENIATES Ohaus, 1917
Trizogeniates Ohaus 1917: 38
Synopsis. Villatoro 2002
Note. Villatoro (2002: 292) and Jameson and Hawkins (2005: 54) considered the genus Trizogeniates as not occurring in the Guianas. The record of a specimen from French Guiana in Soula (2010a: 59) and our find of a Surinamese specimen in the collection of CLVV form thus a significant range extension of this genus.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 126, DOI: 10.5281/zenodo.3678492
Community design variations in students' environmental walking supports
Creators: name: Gallimore, Jonathan Mark
Publisher: name: University of Utah
Year: 2012
Subjects: School children
Pedestrian areas

description: There has been a precipitous decline in the number of children who walk to  school, an activity that can burn calories and provide healthy bouts of physical activity.  This study explores community design among three neighboring communities in Salt  Lake County (New Urban, Mixed, and Suburban), and the role that community design  plays in the micro-level physical features that support walkability along estimated routes  to school.  Fifth grade students and their parents participated from two schools that shared a  boundary but had different community design philosophies. Walkability was assessed  block by block using trained raters and an environmental audit that measures micro  environmental features, the Irvine-Minnesota Inventory (IMI). The IMI items were  combined into six conceptually derived scales: accessibility, crime safety, density,  diversity, pleasurability, and traffic safety. Measures included IMI scores for blocks, for  routes to school, and for the traffic variability along a route to school. Estimated walking  routes to school were based upon the shortest most direct route. Blocks for the estimated  route to school were weighted and combined to characterize each student's walking  route.  Four different questions about walkability were answered. First, at the block  level, New Urban blocks were more walkable than Suburban and Mixed blocks, but  Mixed and Suburban blocks did not differ. Second, when parents and children perceived fewer path barriers and crime concerns for the walk to school then the six IMI walking  route scales also indicated a more walkable route. Third, walking routes in the New  Urban community were more walkable than routes in the Mixed and Suburban  communities, and the Mixed community's walking routes were more walkable than  routes in the Suburban community. Fourth, the Suburban community's walking routes  had more traffic safety variability than either the New Urban or Mixed communities'  routes.  At both block and route levels, the New Urban community is more walkable than  the Mixed and Suburban communities and is perceived that way by parents and children.  This study provides one of the few community comparisons using micro-level  environmental measures of walkability. The use of walking routes was a different  technique that showed key features that related to walking to school and that related to  community design Philosophy;. This study has implications for walkable community  design at micro and macro levels.
Molecular dynamic simulation (MDS) and in vitro cathepsin-B inhibitory activity of decrusin angelate, ibuprofen, and thymol
Creators: name: Sharma, Chanchal
name: Kang, Sun Chul
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer

description: Attenuation of cathepsin B (CATB) proteolytic activity and/or inhibition serves as a potential therapeutic target in cancer metastasis. Herein, we determined the specificity of FDA approved potential anti-cancer natural flavonoid decursinol angelate (DA), thymol (TH) and a propionic acid derivative ibuprofen (IB), for the inactivation of CATB. We used enzymatic assay, computational and in vitro methods for the identification of the best candidate. Out of these we found DA can inhibit CATB with lowest IC50 measured after one hour of incubation using Z-Phe-Arg-4MβNA (BANA) as a substrate. Docking analysis suggested favorable interaction of DA with the catalytic site residues (GLN23, CYS26, HIS110, HIS111) of CATB (PDB Id: 1HUC) were responsible for the inhibition of its proteolytic activity. Additionally, in vitro quantification with human colorectal carcinoma (HCT 116) revealed, DA rapidly inactivates CATB as compared with commercial synthetic inhibitor CA074 with no cellular toxicity towards normal colon cells (CCD 841).
Brief an [Johann Heinrich Lambert]
Creators: name: Schulze, Johann Karl
Publisher: name: [s.n.]
Year: 1774

description: von Johann Carl [Gottlieb] Schulze
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire April 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
1 Brief an [Christian von Mechel]
Creators: name: Lavater, Johann Caspar
Publisher: name: [s.n.]
Year: 1797

description: von [Johann Caspar] Lavater
description: Enthält Notizen Mechels auf der Rückseite
description: Dabei 1 Kärtchen von Lavater an Ungenannt, dat. 16.8.1795 (Nr. 2), 4 Spruchkärtchen, 3 davon gedruckt (Nr. 3-6), 1 Spruch in farbigem Rahmen, dat. 24.11.1794 (Nr. 7), Lavaterporträt von Bromley , publ. 1.2.1789, nach einer Zeichnung vom März 1787 (Nr. 8)
Cytotoxic activity of butanolic extract from Sambucus nigra L. flowers in natura and vehiculated in micelles in bladder cancer cells and fibroblasts
Creators: name: Pereira, Deise Inocêncio
name: Amparo, Tatiane Roquete
name: Almeida, Tamires Cunha
name: Costa, Fernanda Senna Ferreira
name: Brandão, Geraldo Célio
name: Santos, Orlando David Henrique dos
name: da Silva, Glenda Nicioli
name: de Souza, Gustavo Henrique Bianco
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Bladder cancer has a high incidence and recurrence rate among patients worldwide. This study aimed to evaluate the cytotoxic activity of fractions of Sambucus nigra L. flower extracts on bladder carcinoma cells (T24 cells) and human fibroblast cells (MRC-5). The butanolic fraction (F-BuOH) was characterized by UPLC-DAD-MS/MS and nine flavonoids were identified. Rutin was the major compound. The cytotoxic activity of this fraction was observed in the T24 cells but not in MRC-5 cells, indicating selectivity. F-BuOH was incorporated in micellar solutions of Pluronic® F127 and cytotoxic effect for T24 cells was observed again. In vitro assay demonstrated a controlled release of the fraction from the micelles. The results obtained showed that flavonoids are the possible responsible for cytotoxic activity in bladder carcinoma cells. In addition, micellar solutions act together to increase the action of the butanolic fraction.
Synthesis and characterization of responsive nanoporous materials
Creators: name: Abelow, Alexis Elizabeth
Publisher: name: University of Utah
Year: 2012
Subjects: Nanomaterials
Nanoporous
Polymer
Responsive nanoporous materials
Nanoporous membranes
Nanopores

description: This thesis describes the synthesis and properties of polymer or oligonucleotide-modified nanoporous membranes and nanopores which exhibit a response to external stimuli, synthesized with the intention of mimicking biological protein channels. The responsiveness of these systems arises as a  function of the polymer or oligonucleotide modifier, which exhibit a change in conformation with exposure to temperature, pH, introduction of a small molecule,  or electric potential.  First, the transport of ions through supported silica colloidal films modified with poly(L-alanine) on platinum electrodes was studied using cyclic voltammetry.  By monitoring the flux of a redox species through the polymer-modified colloidal film it is demonstrated that the polymer expands and contracts when the  temperature was increased and decreased, respectively. We also observed an expansion and contraction as the pH was increased and decreased, respectively.  Transport of a neutral dye molecule through free-standing silica colloidal films modified with poly(L-alanine) was also studied. As noted previously, the polymer expands and contracts as the pH is increased and decreased, respectively.  Next, the transport was monitored through both silica colloidal film-modified Pt microelectrodes and Pt single nanopore electrodes as an oligonucleotide-based binder, or aptamer, was attached. The aptamer is responsive to a small molecule, cocaine where, in the absence of cocaine, only one "arm" of the aptamer is folded in on itself, leaving the rest of the chain partially unfolded, blocking the nanopores. However, when the cocaine molecule is introduced into solution, the aptamer folds completely in on itself, forming a three-armed structure with the small molecule encapsulated in the middle. This  change in conformation is monitored by observing the change in transport of a redox species through the pores as cocaine is introduced into the system. We observed an increase rate of transport as the aptamer bound to cocaine in both systems, consistent with previous reports of aptamer behavior.  Next, two types of electro-active polymers, polypyrrole (PPy) or poly(3,4-ethylene-dioxythiophene) (PEDOT), were vapor-phase polymerized onto the surface of a commercially available aluminum oxide nanoporous membrane, or Anodisc. These polymers expand in the reduced state and contract in the oxidized state to produce a responsive membrane.
Trizogeniates temporalis Ohaus 1917
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Rutelidae
Trizogeniates
Trizogeniates temporalis

description: Trizogeniates temporalis Ohaus, 1917
Trizogeniates temporalis Ohaus 1917: 41 (Peru)
Distribution. Suriname: CLVV - NEW COUNTRY RECORD (Suriname.). French Guiana: Soula 2010a: 59. Brazil: Villatoro 2002: 262; Jameson and Hawkins 2005: 53. Other: Ohaus 1917: 41 (Peru); Blackwelder 1944: 250 (Ecuador); Machatschke 1972: 361 (Peru); Villatoro 2002: 262 (Bolivia, Peru); Jameson and Hawkins 2005: 53 (Bolivia, Peru).
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 126, DOI: 10.5281/zenodo.3678492
Muricazine, a new hydrazine derivative from Ranunculus muricatus L. with antioxidant, lipoxygenase and urease inhibitory activities
Creators: name: Raziq, Naila
name: Saeed, Muhammad
name: Ali, Muhammad Shaiq
name: Shahid, Muhammad
name: Lateef, Mehreen
name: Zafar, Salman
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Ranunculus muricatus L., an important member of family Ranunculaceae upon submission to phytochemical studies, led to the isolation of a novel natural hydrazine derivative, muricazine (1). Chemical structure of the compound was established with the aid of advanced spectroscopic techniques. It was evaluated for in vitro antioxidant, lipoxygenase, and urease (jack-bean) inhibitory activities. Results suggested that compound 1 could scavenge the DPPH free radical (42.1 ± 0.12 μM) to a great extent as compared to the standard (40.6 ± 0.91 μM). However, it showed moderate inhibitory potential against lipoxygenase (65.2 ± 0.45 μM) and urease (54.8 ± 0.23 μM) enzymes.
Byrsopolis Burmeister 1844
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Rutelidae
Byrsopolis

description: BYRSOPOLIS Burmeister, 1844
Byrsopolis Burmeister 1844: 425
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 126, DOI: 10.5281/zenodo.3678492
Parameters of trained neural network participated in the Prostate cANcer graDe Assessment (PANDA) Challenge
Creators: name: Grechka, Dmitry
Publisher: name: Zenodo
Year: 2020

description: The published data is the parameters of trained neural network submitted to the Prostate cANcer graDe Assessment (PANDA) Challenge. The ensemble prediction using these parameters took 17th place in the challenge.
description: The same data also published as a Kaggle datasets (under the same CC-BY 3.0 license): https://www.kaggle.com/dgrechka/panda-37c https://www.kaggle.com/dgrechka/panda-40c
A molecular dynamics study of effect of polyethylene oxide architecture on self-assembly of carbon nanotubes
Creators: name: Atluri, Pushyami
Publisher: name: University of Utah
Year: 2012
Subjects: Carbon nanotubes
Molecular dynamics
Self assembly
Simulations

description: Carbon nanotubes aggregate strongly to form bundles. One of the ways to control their dispersion is by grafting polymers onto the carbon nanotubes surface. Coarse grained implicit solvent Molecular Dynamics (MD) simulations were used to study the influence of poly (ethylene oxide) (PEO) grafted onto the walls of two single walled carbon nanotubes in water. The system was investigated utilizing both real and repulsive potentials.  The chain length and grafting density of PEO were varied to study their effect on aggregation of carbon nanotubes. PEO has an attractive interaction with the carbon nanotubes which causes aggregation, but at very close distances introduces a repulsive barrier which prevents the nanotubes from aggregating. These competing effects are incorporated into the free energy of the system. It was found that the free energy of the system can be manipulated by changing the chain length and grafting density of the PEO. Simulations investigated the importance of individual contribution of nanotube-PEO and PEO-PEO interaction in water, as well as importance of these contributions to the total energy with respect to changing molecular weight of PEO.
Open Access gemeinsam finanzieren – der KOALA-Ansatz
Creators: name: Schulz, Katharina
name: Tullney, Marco
Publisher: name: Zenodo
Year: 2022
Subjects: open access
collective funding
consortial funding

description: Folien zum Input in die Podiumsdiskussion beim ENABLE!-Werkstattgespräch: "Content sucht Förderer – Open Access ermöglichen" am 14. Juli 2022
description: Funded by/gefördert von: Bundesministerium für Bildung und Forschung (BMBF), Deutschland
description: {"references": ["Benz, Martina, van Edig, Xenia, Schulz, Katharina, Finger, Juliane, & Verbeke, Demmy. (2022). Supporting Diamond Open Access: Research libraries as funders, intermediaries and publishers. Libraries in the Research and Innovation Landscape (LIBER 2022), Odense, Denmark. https://doi.org/10.5281/zenodo.6818082", "Tullney, Marco, Schulz, Katharina, Benz, Martina, & Oberl\u00e4nder, Anja. (2021). KOALA - Konsortiale Open-Access-L\u00f6sungen aufbauen. https://doi.org/10.5281/zenodo.5526697", "Oberl\u00e4nder, Anja, & Tullney, Marco. (2021, April 29). gemeinschaftliche Open-Access-Finanzierung als Aufgabe f\u00fcr Bibliotheken. https://doi.org/10.5281/zenodo.4730883"]}
Fusaroxazin, a novel cytotoxic and antimicrobial xanthone derivative from Fusarium oxysporum
Creators: name: Mohamed, Gamal Abdallah
name: Ibrahim, Sabrin Ragab Mohamed
name: Alhakamy, Nabil Abdulhafiz
name: Aljohani, Omar Saad
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Plant Biology

description: Oxazines and their derivatives are an uncommon natural heterocyclic compounds, which contain oxygen and nitrogen atoms and possess various bioactivities. A novel 1,4-oxazine-xanthone derivative, fusarioxazin (4) and three known sterols (1–3) were separated from Fusarium oxysporum EtOAc extract associated with Vicia faba L. (broad bean, Fabaceae) roots. Their structural assignment was accomplished using various spectroscopic tools and comparing with literature data. The cytotoxic and antimicrobial potentials of the novel metabolite (4) were evaluated. It possessed a significant antibacterial activity towards S. aureus (IZD 14.8 mm and MIC 5.3 µg/mL) and B. cereus (IZD 18.9 mm and MIC 3.7 µg/mL), in comparison to ciprofloxacin (IZDs 16.9 and 20.5 mm; MICs 3.9 and 2.3 µg/mL, respectively). Furthermore, it displayed a promising cytotoxic effect toward HCT-116 (IC50 2.1 µM), MCF-7 (IC50 1.8 µM), and A549 (IC50 3.2 µM) comparable to doxorubicin (IC50s 0.68, 0.54, and 0.39 µM, respectively).
Validity of pulse oximetry during ventilator weaning of adult open heart surgery patients
Creators: name: Appleton, Rebecca Staker
Publisher: name: University of Utah
Year: 2012
Subjects: Heart - Surgery - Nursing
Oximetry
Breathing apparatus
Respirators (Medical equipment)

description: The aims of this research were (a) to evaluate the validity of pulse oximetry as a criterion of tissue oxygenation for nurses to use during ventilator weaning in adult open heart surgery patients, (b) determine which measure of tissue oxygenation (via pulse oximeter or arterial blood gas analyzer) is most valid to use during three phases of ventilator weaning. Little research has been done on ventilator weaning, even though it is an established nursing procedure in critical care units. Measurements of oxygen saturation via pulse oximetry are an established standard of care when weaning ventilator supported patients, yet no research-based data are available to support its widespread use. A descriptive, repeated-measures design was used to assess the agreement of blood oxygen saturation measured by three instruments during three phases of ventilator weaning. Study participants were 16 fair-skinned adults who had open heart surgery. Graphical analyses were computed to assess the agreement between the three blood oxygen saturations. Analyses of data suggest that mean pulse oximeter and mean arterial blood gas oxygen saturations differed by less than 1.7% during ventilator weaning. When mean oxygen saturations from the pulse oximeter and arterial blood gas analyzer were compared with the mean hemoximeter oxygen saturation both exceeded the 'standard' (hemoximeter) by more than 5%, making the measured agreement between them unacceptable. The findings of this study suggest that oxygen saturation measured via pulse oximetry is accurate when compared with data obtained via an arterial blood gas analyzer. However, it is not recommended that nurses abandon the practice of performing arterial blood gases to verify whether or not low SpO2 values measured by pulse oximeter are accurate. Wide fluctuations in Po2 can occur without corresponding changes in SpO2. One statistically significant relationship was found between SpO2 and Po2 r(16) =.63. No significant association was found among pH, Pco2, and core body temperature with SpO2 during ventilator weaning.
Brief an [Johann III Bernoulli]
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1789

description: von J[ohann] C[hristian] Schneider
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire April 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Brief an [Johann III Bernoulli]
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1782

description: von A. Schroeder
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire April 2016 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Byrsopolis aenescens Ohaus 1926
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Rutelidae
Byrsopolis
Byrsopolis aenescens

description: Byrsopolis aenescens Ohaus, 1926
Byrsopolis aenescens Ohaus 1926: 225 (French Guiana)
Distribution. French Guiana: Ohaus 1926: 225; Blackwelder 1944: 235 (as Cotalpa aenescens); Soula 2010a: 54, 2010b: 44; Brûlé and Dalens 2012a annex 4: 18; Carvalho and Grossi 2018: 372. “Guianas”: Ohaus 1934: 38; Machatschke 1972: 3.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on pages 126-127, DOI: 10.5281/zenodo.3678492