cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
A comprehensive assay for nine major cytochrome P450 enzymes activities with 16 probe reactions on human liver microsomes by a single LC/MS/MS run to support reliable in vitro inhibitory drug–drug interaction evaluation
Creators: name: Peng, Ying
name: Wu, Hui
name: Zhang, Xueyuan
name: Wang, Yu
name: Sang, Hua
name: Wang, Guangji
name: Sun, Jianguo
name: Zhang, Fengyi
name: Qi, Huanhuan
name: Zhong, Yunxi
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Virology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Pharmacology
subject: Molecular Biology
subject: Biochemistry
subject: Biophysics

description: 1. A comprehensive method for the simultaneous characterization of xenobiotic compound inhibition of nine major CYP enzymes in human liver microsomes was established by using 16 CYP-catalyzed reactions of 14 probe substrates with three cocktail incubation sets and a single LC/MS/MS analysis.2. The three cocktail subgroups were developed to minimize the effects of organic solvents, polyunsaturated fatty acids and mutual substrate interactions: Group I was composed of tolbutamide (CYP2C9), S-mephenytoin (CYP2C19), testosterone (CYP3A4), dextromethorphan (CYP2D6); Group II was composed of nifedipine (CYP3A4), midazolam (CYP3A4), coumarin (CYP2A6), bupropion (CYP2B6), diclofenac (CYP2C9); Group III was composed of phenacetin (CYP1A2), chlorzoxazone (CYP2E1), omeprazole (CYP2C19 and CYP3A4), paclitaxel (CYP2C8), (+)-bufuralol (CYP2D6). In the case of CYP2C9, CYP2C19, CYP2D6 and CYP3A4, multiple probe substrates were used due to the phenomenon of multiple substrate-binding pockets and substrate-dependent inhibition. All probe metabolites were simultaneously analyzed with a polarity switching mode in a single LC/MS/MS run.3. This method was validated against the single probe substrate assay using 12 well-characterized CYP inhibitors and two new entities (GT0918, MDV3100). The IC50 values of each inhibitor in the cocktail agreed well with that of the individual probe drug as well as with values reported in previous literatures.
Biophysical study on the interaction of etomidate and the carrier protein in vitro
Creators: name: Liu, Wei
name: Liu, Aijie
name: Liu, Guoqiang
name: Wang, Dewei
name: Chen, Kui
name: Wang, Hongying
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Etomidate is a unique drug used for induction of general anesthesia and sedation, and is usually used through intravenous injection clinically. Before targeting to the receptor, etomidate binds proteins in blood when it comes into veins. Thus to study the interaction of etomidate and serum albumin would be of great toxicological and pharmacological importance. In this study, the interaction between etomidate and human serum albumin (HSA) was studied using fluorescence spectroscopy, UV–vis absorption spectroscopy, Fourier transform infrared spectroscopy (FT-IR), circular dichroism (CD) spectroscopy, site maker displacement and molecular modeling methods. Investigations of the binding constant (K = 3.55 × 105 M−1, 295 K), the number of binding sites (n = 1.16), thermodynamic parameters (ΔG = 3.13 × 104 J·mol−1, ΔS = 364 J·mol−1·K−1 and ΔH = −6.85 × 105 J·mol−1) for the reaction and changes to the binding sites and conformation in HSA in response to etomidate were presented. Results show that etomidate can bind HSA tightly through electrostatic forces, and the protein skeleton conformation and secondary structure changes thereby. This is the first spectroscopic report for etomidate–HSA interactions which illustrates the complex nature of this subject.
Asymmetric synthesis and biological activities of natural product (+)-balasubramide and its derivatives
Creators: name: Li, Jun
name: Li, Jianzu
name: Xu, Yuan
name: Wang, Yunjie
name: Zhang, Luyong
name: Ding, Li
name: Xuan, Yining
name: Pang, Tao
name: Lin, Hansen
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine

description: The natural product (+)-balasubramide (3j) and its derivatives (3a–3i) were synthesized using a two-step asymmetric synthesis, and the biological activities of 3a–3j were determined in vitro. Methyl (2S,3R)-(+)-3-phenyloxirane-2-carboxylate (1h), the asymmetric synthesis of which was described in a previous paper, was selected as the starting material. Compounds 3a–3j were evaluated for their neuroprotective, antioxidative, and anti-neuroinflammatory effects. (+)-Balasubramide and its derivatives with different electronegative groups in the 6-phenyl ring produced little neuroprotection and antioxidation, but induced potent anti-neuroinflammatory effects in BV-2 microglial cells (with the exception of 3g). Compound 3c, with a trifluoromethyl group in its 6-phenyl ring, was a particularly potent anti-neuroinflammatory agent. These results demonstrated that the electronegativity of the 6-phenyl ring of (+)-balasubramide is an important determinant of its inhibitory effect on neuroinflammation. More electronegative substituents result in more potent anti-neuroinflammatory effects. Moreover, cytotoxicity assays indicated no significant effects of the tested compounds.
The corrected structure of depressoside, an antioxidative iridoid glucoside extracted from the flowers of Gentiana urnula Harry Sm.
Creators: name: Kusakari, Ken
name: Fukuhara, Tadao
name: Motoyama, Akira
name: Ochiai, Nobuhiko
name: Watanabe, Takashi
name: Sugimoto, Yukihiro
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Developmental Biology
subject: Cancer

description: Three known iridoid glucosides (gentiournoside A, gentiournoside E and depressoside) were isolated from the flowers of Gentiana urnula Harry Sm. through activity-guided fractionations with a 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. All three compounds exhibited excellent DPPH radical scavenging activities (IC50: 10–20 μmol L−1) comparable to that of ascorbic acid and Trolox. However, examination of the NMR data revealed that the reported chemical structure of depressoside, previously isolated from the leaves of G. depressa, needed correcting due to incorrect elucidation around C-7 of the iridane skeleton, and was corrected to 6-β-(2,3-dihydroxyphenyl)-d-glucosyl 7-O-(2,3-dihydroxybenzoyl)-loganate. Depressoside exhibited a much higher scavenging activity against superoxide radicals (IC50: 45.5 μmol L−1) than the other two extracted compounds (IC50: more than 900 μmol L−1) due to the crucial presence of a pyrogallyl unit.
The corrected structure of depressoside, an antioxidative iridoid glucoside extracted from the flowers of Gentiana urnula Harry Sm.
Creators: name: Kusakari, Ken
name: Fukuhara, Tadao
name: Motoyama, Akira
name: Ochiai, Nobuhiko
name: Watanabe, Takashi
name: Sugimoto, Yukihiro
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Developmental Biology
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biochemistry

description: Three known iridoid glucosides (gentiournoside A, gentiournoside E and depressoside) were isolated from the flowers of Gentiana urnula Harry Sm. through activity-guided fractionations with a 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. All three compounds exhibited excellent DPPH radical scavenging activities (IC50: 10–20 μmol L−1) comparable to that of ascorbic acid and Trolox. However, examination of the NMR data revealed that the reported chemical structure of depressoside, previously isolated from the leaves of G. depressa, needed correcting due to incorrect elucidation around C-7 of the iridane skeleton, and was corrected to 6-β-(2,3-dihydroxyphenyl)-d-glucosyl 7-O-(2,3-dihydroxybenzoyl)-loganate. Depressoside exhibited a much higher scavenging activity against superoxide radicals (IC50: 45.5 μmol L−1) than the other two extracted compounds (IC50: more than 900 μmol L−1) due to the crucial presence of a pyrogallyl unit.
The expression of RNA helicase DDX5 is transcriptionally upregulated by calcitriol through a vitamin D response element in the proximal promoter.
Creators: name: González-Duarte, Ramiro José
Publisher: name: figshare
Year: 2017
Subjects: Molecular Biology

description: The DEAD box RNA helicase DDX5 is a multifunctional protein involved in the regulatory events of gene expression. Our study shows that DDX5 gene is transcriptionally upregulated by calcitriol through a VDRE located in its proximal promoter.
Calcitriol increases Dicer expression and modifies the microRNAs signature in SiHa cervical cancer cells
Creators: name: González-Duarte, Ramiro José
Publisher: name: figshare
Year: 2017
Subjects: Molecular Biology

description: The catalytic activities of Drosha and Dicer ribonucleases are essential in the miRNA biogenesis. Deregulated levels of these key enzymes are associated with impaired miRNA maturation and tumorigenesis in animal models and in a variety of human cancers.Our results indicate that in SiHa cells, calcitriol stimulates the expression of Dicer, possibly through the vitamin D response element located in its promoter. This may explain the calcitriol dependent modulation of microRNAs whose target mRNAs are related to anticancer pathways, further adding to the various anticancer mechanisms of calcitriol.
Synthesis, crystal structure, and magnetism of the binuclear radical complex [N-hydrogenpyridinium]2[Ni(tdas)2]2
Creators: name: Wang, Chi-Feng
name: Qiao, Fang
name: Chi, Yan-Hui
name: Shi, Jing-Min
name: Cottrill, Ethan
name: Pan, Ning
name: Zhu-ge, Wei-Wei
name: Fu, Yong-Xin
name: Xu, Jun
name: Qian, Xiao-Ping
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Chemistry
Earth and Environmental Sciences
Cell Biology
Biochemistry
Biophysics

description: The binuclear radical complex [N-hydrogenpyridinium]2[Ni(tdas)2]2 (tdas = 1,2,5-thiazole-3,4-dithiolate) has been prepared and its crystal structure determined by X-ray crystallography. In the binuclear radical complex, the two nickel ions assume a distorted pyramidal geometry and are bridged by two sulfurs of different tdas anionic ligands. ESR spectra and the theoretical calculations reveal a very strong antiferromagnetic interaction in the binuclear radical complex, leading to diamagnetic crystals. The theoretical calculations also reveal a very weak antiferromagnetic interaction between adjacent radical complexes. This study is the first to report the magnetism of a binuclear radical nickel complex with tdas as ligand.
Dynamic latent trait models with mixed hidden Markov structure for mixed longitudinal outcomes
Creators: name: Zhang, Yue
name: Berhane, Kiros
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences

description: We propose a general Bayesian joint modeling approach to model mixed longitudinal outcomes from the exponential family for taking into account any differential misclassification that may exist among categorical outcomes. Under this framework, outcomes observed without measurement error are related to latent trait variables through generalized linear mixed effect models. The misclassified outcomes are related to the latent class variables, which represent unobserved real states, using mixed hidden Markov models (MHMMs). In addition to enabling the estimation of parameters in prevalence, transition and misclassification probabilities, MHMMs capture cluster level heterogeneity. A transition modeling structure allows the latent trait and latent class variables to depend on observed predictors at the same time period and also on latent trait and latent class variables at previous time periods for each individual. Simulation studies are conducted to make comparisons with traditional models in order to illustrate the gains from the proposed approach. The new approach is applied to data from the Southern California Children Health Study to jointly model questionnaire-based asthma state and multiple lung function measurements in order to gain better insight about the underlying biological mechanism that governs the inter-relationship between asthma state and lung function development.
Pulsatility index in combination with biomarkers or mean arterial pressure for the prediction of pre-eclampsia: Systematic literature review and meta-analysis
Creators: name: Zhu, Xiao-lu
name: Wang, Juan
name: Jiang, Rong-Zhen
name: Teng, Yin-Cheng
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Astronomy, Astrophysics, Space Science
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biophysics

description: Introduction. Our objective was to perform a meta-analysis examining the sensitivity of pulsatility index (PI) and various biomarkers and PI and mean arterial pressure (MAP) for the prediction of pre-eclampsia.Material and methods. PubMed, CENTRAL, and Embase databases were searched from inception until 8 May 2014 using combinations of the search terms: pre-eclampsia, ultrasonography, pregnancy, biomarker, mean arterial pressure, placental protein 13, pregnancy-associated plasma protein-A, placental growth factor, activin A, inhibin A, pulsatility index. The pooled sensitivity of PI + biomarkers and PI + MAP were calculated, and reported with corresponding 95% confidence intervals (CIs).Results. Fifteen studies were included in the meta-analysis. The pooled sensitivity of all biomarkers for the prediction of pre-eclampsia was 0.669 (95% CI 0.610–0.723), for the prediction of early-onset pre-eclampsia was 0.830 (95% CI 0.794–0.861), and for the prediction of late-onset pre-eclampsia was 0.564 (95% CI 0.499–0.627). Similarly, the predictive ability of PI + MAP for early-onset pre-eclampsia was good (sensitivity 0.894), while that for late-onset was poor (sensitivity 0.570).Conclusion. The combination of PI and different biomarkers or MAP exhibits a good predictive ability for early-onset pre-eclampsia, and poor predictive ability for late-onset pre-eclampsia.
title: Indigenous self-governance for mental health and suicide prevention
Creators: name: Australian Institute of Health and Welfare
Publisher: name: Australian Institute of Health and Welfare
Year: 2022
Subjects: subject: FOS: Health sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: There is evidence from Canada, that self-governing First Nation Canadian communities have fewer or no instances of youth suicide. Similarly, findings from a study of two Indigenous Australian communities experiencing very high suicide rates suggest that the process of taking back governance of their own affairs achieved positive impacts, including a reduction in suicides and increased community capacity to deal with associated social and cultural issues.
2007 Organic Farm Performance in Minnesota
Creators: name: Nordquist, Dale
name: Dvergsten, Ron
name: Moynihan, Meg
name: Nordquist, Dale
name: Dvergsten, Ron
name: Moynihan, Meg
Publisher: name: Unknown
Year: 2007
Subjects: Crop Production/Industries
Farm Management

description: This report summarizes the individual farm financial results for participants in the Minnesota Organic Farm Business Management Project for 2007 with comparisons to 2006 performance. Whole farm information and enterprise costs and returns are reported. The year-end analysis of the individual farms was completed by Minnesota Farm Business Management Education Program instructors or by Minnesota Farm Management Associations. A total of 65 farms participated in the program for 2007, down slightly from 71 in 2006. Of those, 45 were "total organic," meaning that all of the agricultural products produced on the farm were produced under organic certification, and 20 were "partial organic," having both certified organic and non-organic production:-'
Merge Is Not Recursion
Creators: name: Casares, Ramón
Publisher: name: figshare
Year: 2017
Subjects: subject: Linguistics
subject: FOS: Languages and literature

description: This is a review of the book "Why Only Us" by Berwick & Chomsky done from the point of view of computing. The main conclusions are: that the book uses the word "recursion" with a meaning that does not correspond to the meaning used in mathematics, causing confusion, and that the theory proposed in the book, that syntax is just Merge, cannot be translated sensibly to computing, because Merge by itself cannot even parse, and therefore it is not enough to explain the evolution of Merge to explain the evolution of language, as the book pretends.
Diverse structures, magnetism and photoluminescence of four transition metal coordination compounds based on the semirigid 4-(pyridin-3-yloxy)-phthalic acid
Creators: name: Zhang, Lingling
name: Gao, Peng
name: Zhang, Yanhong
name: Hu, Ming
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Chemistry
Earth and Environmental Sciences
Physics
Biochemistry

description: Four transition metal coordination compounds, {[Co(PPDA)(H2O)2]}n (1), {[Ni(HPPDA)2]}n (2), {[Cd(PPDA)(H2O)]∙H2O}n (3) and {Zn(HPPDA)2(H2O)4}n (4), were synthesized by assembling transition metal salts with a semirigid ligand 4-(pyridin-3-yloxy)-phthalic acid (H2PPDA) under hydrothermal conditions. The compounds have been characterized by elemental analyses, IR spectra, TGA, powder X-ray diffraction (PXRD) and single crystal X-ray crystallography. Compound 1 exhibits a 3-connected 2-D layered structure, 2 shows a (3,6)-connected 2-D layered structure, 3 displays a (3,6)-connected 2-D layered framework based on binuclear units, and 4 is a mononuclear structure, connected to generate a 3-D supramolecular architecture by hydrogen bonds. Compound 2 is thermally stable up to 300 °C. The magnetic properties of 1 and photoluminescent properties of 3 and 4 have been explored.
Diverse structures, magnetism and photoluminescence of four transition metal coordination compounds based on the semirigid 4-(pyridin-3-yloxy)-phthalic acid
Creators: name: Zhang, Lingling
name: Gao, Peng
name: Zhang, Yanhong
name: Hu, Ming
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Biological Sciences
Chemistry
Earth and Environmental Sciences
Physics
Biochemistry

description: Four transition metal coordination compounds, {[Co(PPDA)(H2O)2]}n (1), {[Ni(HPPDA)2]}n (2), {[Cd(PPDA)(H2O)]∙H2O}n (3), and {Zn(HPPDA)2(H2O)4}n (4), were synthesized by assembling transition metal salts with a semirigid ligand 4-(pyridin-3-yloxy)-phthalic acid (H2PPDA) under hydrothermal conditions. The compounds have been characterized by elemental analyses, IR spectra, TGA, powder X-ray diffraction, and single-crystal X-ray crystallography. Compound 1 exhibits a three-connected 2-D layered structure, 2 shows a (3,6)-connected 2-D layered structure, 3 displays a (3,6)-connected 2-D layered framework based on binuclear units, and 4 is a mononuclear structure, connected to generate a 3-D supramolecular architecture by hydrogen bonds. Compound 2 is thermally stable up to 300 °C. The magnetic properties of 1 and photoluminescent properties of 3 and 4 have been explored.
Two 3-Amino-1,2,4-triazole-based Manganese(II) Complexes Incorporated With Different Dicarboxylate Coligands: Synthesis, Structure, and Magnetism
Creators: name: Zhang, Xi-Ying
name: Zhao, Hong
name: Liu, Zhong-Yi
name: Cao, Ying-Yu
name: Yang, En-Cui
name: Zhao, Xiao-Jun
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Molecular Biology
subject: Physics
subject: Biochemistry

description: Two 3-amino-1,2,4-triazole (Hatz)-based magnetic complexes, {[Mn3(H2O)2(Hatz)2(sip)2]·2H2O}n (1) and {[Mn(H2O)3(Hatz)(bda)]·H2O}n (2) (sip3− = 5-sulfoisophthalate and bda2− = trans-butenedioate), were respectively prepared by varying dicarboxylate-containing coligands, and were structurally and magnetically characterized. Structural determinations reveal that 1 exhibits a two-dimensional layered structure with linear {Mn3(μ-N1,N2-Hatz)2}6+ subunits extended by tritopic sip3− connectors. By contrast, 2 is an infinite zigzag chain constructed from octahedral Mn(II) ions and μ-N1,N4-Hatz linkers. Magnetically, typically antiferromagnetic interaction observed in the local MnII3 subunit of 1 mediated by mixed μ-syn, syn-COO− and μ-N1,N2-Hatz heterobridges is slightly stronger than that of 2 transmitted by single μ-N1,N4-Hatz mediator.
Two 3-amino-1,2,4-triazole-based Manganese(II) Complexes Incorporated with Different Dicarboxylate Coligands: Synthesis, Structure, and Magnetism
Creators: name: Zhang, Xi-Ying
name: Zhao, Hong
name: Liu, Zhong-Yi
name: Cao, Ying-Yu
name: Yang, En-Cui
name: Zhao, Xiao-Jun
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Molecular Biology
subject: Physics
subject: Biochemistry

description: Two 3-amino-1,2,4-triazole (Hatz)-based magnetic complexes, {[Mn3(H2O)2(Hatz)2(sip)2]·2H2O}n (1) and {[Mn(H2O)3(Hatz)(bda)]·H2O}n (2) (sip3− = 5-sulfoisophthalate and bda2− = trans-butenedioate), were respectively prepared by varying dicarboxylate-containing coligands, and were structurally and magnetically characterized. Structural determinations reveal that 1 exhibits a two-dimensional layered structure with linear {Mn3(μ-N1,N2-Hatz)2}6+ subunits extended by tritopic sip3− connectors. By contrast, 2 is an infinite zigzag chain constructed from octahedral Mn(II) ions and μ-N1,N4-Hatz linkers. Magnetically, typically antiferromagnetic interaction observed in the local MnII3 subunit of 1 mediated by mixed μ-syn, syn-COO− and μ-N1,N2-Hatz heterobridges is slightly stronger than that of 2 transmitted by single μ-N1,N4-Hatz mediator.
Filtration Efficiency of Non-Uniform Fibrous Filters
Creators: name: Shou, Dahua
name: Fan, Jintu
name: Zhang, Heng
name: Qian, Xiaoming
name: Ye, Lin
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Earth and Environmental Sciences
subject: Cell Biology
subject: Physics
subject: Engineering
subject: Biochemistry

description: Although theoretical models of the filtration efficiency of fibrous filters are typically based on a single type of fiber in an ordered array, many actual fibrous filters are composed of fibers that are inherently randomly distributed. It is desirable to be able to estimate the filtration efficiency of such non-uniform fibrous filters from their composition arrangement and the filtration property of individual fibers. Toward that end, we approximate the filter system as a series of cells composed of individual fibers with random distribution, deviating from the homogeneity assumption in the classical models. With better characterization of the filter structure on the basis of the Voronoi diagram, we theoretically revisit filtration efficiency by the top-down (TD) approach and the bottom-up (BU) approach. The proposed models are compared with existing experimental and numerical results under different fiber volume fractions, indicating the high accuracy of the TD model for the filtration of submicron aerosol particles. The influence of the degree of randomness of fiber distribution on filtration efficiency is also quantified.
Filtration Efficiency of Non-Uniform Fibrous Filters
Creators: name: Shou, Dahua
name: Fan, Jintu
name: Zhang, Heng
name: Qian, Xiaoming
name: Ye, Lin
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Earth and Environmental Sciences
subject: Cell Biology
subject: Physics
subject: Engineering
subject: Biochemistry

description: Although theoretical models of the filtration efficiency of fibrous filters are typically based on a single type of fiber in an ordered array, many actual fibrous filters comprises fibers that are inherently randomly distributed. It is desirable to be able to estimate the filtration efficiency of such non-uniform fibrous filters from their composition arrangement and the filtration property of individual fibers. Toward that end, we approximate the filter system as a series of cells comprising individual fibers with random distribution, deviating from the homogeneity assumption in the classical models. With better characterization of the filter structure based on the Voronoi diagram, we theoretically revisit filtration efficiency by the top-down (TD) approach and the bottom-up approach. The proposed models are compared with the existing experimental and numerical results under different fiber volume fractions, indicating the high accuracy of the TD model for the filtration of submicron aerosol particles. The influence of the degree of randomness of fiber distribution on filtration efficiency is also quantified.Copyright 2015 American Association for Aerosol Research
Merge Is Not Recursion
Creators: name: Casares, Ramón
Publisher: name: figshare
Year: 2017
Subjects: subject: Linguistics
subject: FOS: Languages and literature

description: This is a review of the book "Why Only Us" by Berwick & Chomsky done from the point of view of computing. The main conclusions are: that the book uses the word "recursion" with a meaning that does not correspond to the meaning used in mathematics, causing confusion, and that the theory presented in the book, that syntax can be reduced to Merge, does not translate sensibly to computing, because Merge by itself cannot even parse, and therefore it is not enough to explain the evolution of Merge to explain the evolution of language, as the book proposes.
Luze
Creators: name: Man, Michelle
name: Hewison, James
Publisher: name: Edge Hill University
Year: 2020
Subjects: subject: 190403 Dance
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: 'Luze' was co-choreographed by Senior Lecturers James Hewison and Michelle Man and created in collaboration with the female Basque composer Zuriñe F. Gerenabarrena. Programmed as part of the commission that Ensemble Sinkro received from Fundación Juan March, Madrid, this ground-breaking event saw the introduction of the programming of dance to the prestigious Fundación Juan March, an international concert and gallery space founded in 1955. For this work the collaborating artists explored notions and the embodiment through sound and the choreographic of duration, or as luze translates literally from Euskera ‘long’. This is the recording of the live performance on 4th March 2017 at the Fundación Juan March.
Complete mtDNA genomes reveal similar penetrances of maternally inherited type 2 diabetes in two Chinese families
Creators: name: Yang, Ying
name: Zhou, Taicheng
name: Peng, Minsheng
name: Liu, Yongying
name: Li, Yiping
name: Wang, Huawei
name: M. Irwin, David
name: Zhang, Yaping
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Previous work suggests that mitochondrial DNA (mtDNA) derived from the maternal genome has a close affinity with type 2 diabetes. This would support a familial pattern for type 2 diabetes. Thereby, we analyzed complete mtDNA genomes from two families, A and B, from Southwest China that demonstrated maternally inherited type 2 diabetes. Our data support that mtDNA lineages from families A and B belong to haplogroups A4 and D4h1, respectively. This suggests that maternally inherited type 2 diabetes with similar penetrances can arise in Chinese individuals with strikingly different maternal genetic backgrounds. Two private coding region mutations (G13759A in MT-ND5 and G15930A in tRNA-Thr) were identified in family B. Further evolutionary and phylogenetic analyses suggest that both these mutations have multiple origins and are unlikely to be disease causing.
Chiral resolution, determination of absolute configuration, and biological evaluation of (1,2-benzothiazin-4-yl)acetic acid enantiomers as aldose reductase inhibitors
Creators: name: Hao, Xin
name: Zhang, Wei
name: Ma, Bing
name: Qin, Xiangyu
name: Hussain, Saghir
name: Parveen, Shagufta
name: Fu, Fengyan
name: Zhu, Changjin
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Hematology
subject: Cancer
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: A novel series of (1,2-benzothiazin-4-yl)acetic acid enantiomers was prepared by chiral resolution, and their absolute configurations were determined using the PGME method. The biological evaluation of the racemate and single enantiomers has shown a remarkable difference for the aldose reductase inhibitory activity and selectivity. The (R)-(−)-enantiomer exhibited the strongest aldose reductase activity with an IC50 value of 0.120 μM, which was 35 times more active than the S-(+)-enantiomer. Thus, the stereocenter at the C4 position of this scaffold was shown to have a major impact on the activity and selectivity.
Doxorubicin-loaded microgels composed of cinnamic acid–gelatin conjugate and cinnamic acid–Pluronic F127 conjugate
Creators: name: Zhang, Hong
name: Kim, Jin-Chul
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology
subject: Virology

description: Microgels were prepared by cinnamic acid–gelatin (type B) conjugate (CA-GelB) and cinnamic acid–Pluronic F127 conjugate (CA-Plur). 1H NMR confirmed that CA was conjugated to gelatin and the gelatin to CA residue molar ratio was estimated to be 1:4.7 by a colorimetric method. CA-Plur of which the CA residue to Plur molar ratio was 1.2:1 was used as a thermo-sensitive polymer. The CA residues of CA-Plur/CA-GelB mixture were readily photo-dimerized to form microgels by UV irradiation. The isoelectric point of the microgel was found to be pH 5.8 and the hydrodynamic diameter decreased when the suspension temperature increased. The microgel could hardly retard the release of doxorubicin (DOX) at pH 3.0 and pH 5.0, but it could suppress and control the release at pH 7.4 possibly due to electrostatic attraction. Meanwhile, the release of DOX at pH 7.4 was less suppressed when the medium temperature was higher, possibly because of thermal thinning of Pluronic chain layer.
Characterization of the mitogenome of Uropsilus gracilis and species delimitation
Creators: name: Hou, Quanfen
name: Tu, Feiyun
name: Liu, Yang
name: Liu, Shaoying
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Plant Biology

description: The species diversity within the genus Uropsilus were underestimated: 10 species among the genus Uropsilus have been proposed. In this study, the complete mitochondrial genome of U. gracilis, with the topotype, was determined. It is 16,536 bp in length, comprising of 13 protein-coding genes (PCGs), 2 rRNA genes, 22 tRNA genes and 1 control region. The composition and arrangement of its genes are similar to most other mammals. The total base composition of the mitogenome is A, 33.4%; T, 30.3%; C, 22.7% and G, 13.6%, with a rich content of A+T pattern. We performed the similarity comparison based on 13 PCGs of three species of Asiatic shrew-like mole, U. gracilis, U. sp. 1 and U. soricipes. Pairwise sequence alignment showed that similarity data of U. gracilis versus U. sorcipes are significantly higher than those of U. gracilis versus U. sp.1. This pointed toward a cryptic species (U. sp.1) from Jiajin Mountains rather than U. gracilis.
Complete mitochondrial genome of the urohaze-goby Glossogobius olivaceus (Perciformes, Gobiidae) and structure comparison of light strand replication origin in Gobioidei
Creators: name: Sun, Yuena
name: Wei, Tao
name: Jin, Xiaoxiao
name: Qin, Yu
name: Xu, Tianjun
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Virology
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences
subject: Evolutionary Biology
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Microbiology
subject: Biochemistry

description: The genome of Glossogobius olivaceus (G. olivaceus) was 16,568 bp in length with a standard set of 13 protein-coding genes, 22 transfer RNA genes (tRNAs), 2 ribosomal RNA genes (rRNAs) and 2 non-coding region (the control region and origin of the light strand replication). The conserved motif 5′-GCCGG-3′ was determined in the origin of light strand replication of G. olivaceus. The G. olivaceus mitogenome base composition was: T 25.65%, C 29.82% A 27.17% and G 17.36%, with a slight A + T bias of 52.82%, which was similar to most of the vertebrate mitogenomes. The mitochondrial genome of G. olivaceus had common features regarding gene arrangement and tRNA structures compared with those of other bony fishes.
Characterization of the platelet transcriptome by RNA sequencing in patients with acute myocardial infarction
Creators: name: D. Eicher, John
name: Wakabayashi, Yoshiyuki
name: Vitseva, Olga
name: Esa, Nada
name: Yang, Yanqin
name: Zhu, Jun
name: E. Freedman, Jane
name: D. McManus, David
name: D. Johnson, Andrew
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Infectious Diseases
subject: FOS: Health sciences
subject: Hematology
subject: Developmental Biology
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biochemistry

description: Transcripts in platelets are largely produced in precursor megakaryocytes but remain physiologically active as platelets translate RNAs and regulate protein/RNA levels. Recent studies using transcriptome sequencing (RNA-seq) characterized the platelet transcriptome in limited number of non-diseased individuals. Here, we expand upon these RNA-seq studies by completing RNA-seq in platelets from 32 patients with acute myocardial infarction (MI). Our goals were to characterize the platelet transcriptome using a population of patients with acute MI and relate gene expression to platelet aggregation measures and ST-segment elevation MI (STEMI) (n = 16) vs. non-STEMI (NSTEMI) (n = 16) subtypes. Similar to other studies, we detected 9565 expressed transcripts, including several known platelet-enriched markers (e.g. PPBP, OST4). Our RNA-seq data strongly correlated with independently ascertained platelet expression data and showed enrichment for platelet-related pathways (e.g. wound response, hemostasis, and platelet activation), as well as actin-related and post-transcriptional processes. Several transcripts displayed suggestively higher (FBXL4, ECHDC3, KCNE1, TAOK2, AURKB, ERG, and FKBP5) and lower (MIAT, PVRL3, and PZP) expression in STEMI platelets compared to NSTEMI. We also identified transcripts correlated with platelet aggregation to TRAP (ATP6V1G2, SLC2A3), collagen (CEACAM1, ITGA2), and ADP (PDGFB, PDGFC, ST3GAL6). Our study adds to current platelet gene expression resources by providing transcriptome-wide analyses in platelets isolated from patients with acute MI. In concert with prior studies, we identify various genes for further study in regards to platelet function and acute MI. Future platelet RNA-seq studies examining more diverse sets of healthy and diseased samples will add to our understanding of platelet thrombotic and non-thrombotic functions.
ONA TILI TA'LIM MAZMUNINI TAKOMILLASHTIRISHDA BILIM EGALLASHNING TIZIMLI XUSUSIYATLARI
Creators: name: Qurbonova, O. B.
Publisher: name: Zenodo
Year: 2025

description: Mazkur maqolada  ona tili ta’lim mazmunining   tarkibiy qislari va ta’lim maqsadining  mutanosibligini takomillashtirish, ta’lim jarayoni subyektlarida metodik-pedagogik bilimlar yig‘indisini, sohaga oid fanlar integratsiyalashuvini, axborotlar bilan ishlash ko‘nikmalarini rivojlantirish va nutqiy-kasbiy  faoliyatda ulardan foydalanish  hamda tatbiq qilish bo ‘yicha  olimlar  ilmiyqarashlari keltirilib tahliliy yondashuvlar izohlangan.
Complete mitochondrial genome of the Freshwater Catfish Rita rita (Siluriformes, Bagridae)
Creators: name: Lashari, Punhal
name: Younis Laghari, Muhammad
name: Xu, Peng
name: Zhao, Zixia
name: Jiang, Li
name: Tariq Narejo, Naeem
name: Deng, Yulin
name: Sun, Xiaowen
name: Zhang, Yan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Infectious Diseases
subject: FOS: Health sciences
subject: Science Policy
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences
subject: Evolutionary Biology
subject: Genetics
subject: Microbiology

description: The complete mitochondrial genome of Catfish, Rita rita, was isolated by LA PCR (TakaRa LAtaq, Dalian, China); and sequenced by Sanger’s method to obtain the complete mitochondrial genome, which is listed Critically Endangered and Red Listed species. The complete mitogenome was 16,449 bp in length and contains 13 typical vertebrate protein-coding genes, 2 rRNA and 22 tRNA genes. The whole genome base composition was estimated to be 33.40% A, 27.43% C, 14.26% G and 24.89% T. The complete mitochondrial genome of catfish, Rita rita provides the basis for genetic breeding and conservation studies.
title: Connection to community
Creators: name: Australian Institute of Health and Welfare
Publisher: name: Australian Institute of Health and Welfare
Year: 2022
Subjects: subject: FOS: Health sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Connections to community are an important source of resilience for Indigenous Australians. Previous research has shown that being connected to community builds a sense of cultural identity which can reduce suicide. Although clinically based evidence is vital to targeted interventions with at-risk individuals, an understanding of social determinants of suicide is increasingly important in developing prevention strategies, interventions, and initiatives that connect people to community support.
MEDIDAS DE RESSOCIALIZAÇÃO PARA A REINTEGRAÇÃO SOCIAL DE PRESOS
Creators: name: Alisson Iago Alves da LUZ
name: Lucas Alves de Sousa BRAGA
name: Márcio Adriano Cabral de SOUZA
Publisher: name: Zenodo
Year: 2024
Subjects: Sistema Prisional
Ressocialização do Preso
Reintegração Social

description: RESUMO

Este artigo tem como objetivo analisar as medidas de ressocialização implementadas no sistema prisional brasileiro, com foco na sua eficácia para a concretização da reintegração social dos presos. A pesquisa, de natureza bibliográfica e abordagem qualitativa, revisa a literatura existente sobre os programas e políticas de ressocialização, explorando as melhores práticas e os desafios enfrentados na sua implementação. O estudo aborda a importância de iniciativas como a educação, a capacitação profissional e o apoio psicológico, essenciais para preparar os detentos para uma reinserção bem-sucedida na sociedade. A análise revela que, apesar de algumas iniciativas apresentarem resultados positivos, a efetividade das medidas de ressocialização ainda enfrenta obstáculos significativos, como a falta de recursos, infraestrutura inadequada e a persistente estigmatização social. Os resultados indicam  que, para alcançar a reintegração social de maneira efetiva, é necessário um esforço conjunto entre o Estado e a sociedade, garantindo que as políticas de ressocialização sejam aplicadas de forma contínua e abrangente. Assim, o estudo contribui para a discussão sobre a importância de políticas públicas mais eficazes e integradas que promovam a ressocialização dos presos, visando à redução da reincidência criminal e à construção de uma sociedade mais justa e inclusiva.
The reciprocal calculation procedure for setting occupational exposure limits for hydrocarbon solvents: An update
Creators: name: McKee, Richard H.
name: M. David Adenuga
name: Juan-Carlos Carrillo
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Hydrocarbon solvents are liquid hydrocarbon fractions, often with complex compositions. Due to the potential for human exposure, primarily to the more volatile solvents, substantial effort has been directed toward the development of occupational exposure recommendations. Because of the complex and variable nature of these substances, a proposed approach is to calculate occupational exposure levels (OELs) using an adaptation of the mixture formula developed by the ACGIH® in which “group guidance values” are assigned to similar constituents. This approach is supported by the results of toxicological studies of hydrocarbon solvents and their constituents which have shown that, with a few well-characterized exceptions, these substances have similar toxicological properties and produce additive effects. The objective of the present document is to summarize recommended revisions to the earlier proposals; these recommendations take into account recent toxicological information and changes in regulatory advice. Practical demonstrations on how to use these recommendations to develop occupational exposure advice in different situations (from simple complex solvents to blends of complex solvents) are also provided. Finally, a quantitative ideal gas method is proposed as a means of calculating occupational exposure limits for solvent blends in which, because the blended components have differing vapor pressures, there may be substantial differences between the liquid and vapor phase compositions.
Pairwise Meta-Modeling of Multivariate Output Computer Models Using Nonseparable Covariance Function
Creators: name: Li, Yongxiang
name: Zhou, Qiang
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Mathematics
subject: FOS: Mathematics
subject: Information and Computing Sciences
subject: Biological Sciences

description: The Gaussian process (GP) model is a popular method for emulating deterministic computer simulation models. Its natural extension to computer models with multivariate outputs employs a multivariate Gaussian process (MGP) framework. Nevertheless, with significant increase in the number of design points and the number of model parameters, building a MGP model is a very challenging task. Under a general MGP model framework with nonseparable covariance functions, we propose an efficient meta-modeling approach featuring a pairwise model building scheme. The proposed method has excellent scalability even for a large number of output levels. Some properties of the proposed method have been investigated and its performance has been demonstrated through several numerical examples. Supplementary materials of this paper are available online.
A branch-and-price algorithm for the home health care scheduling and routing problem with stochastic service times and skill requirements
Creators: name: Liu, Ran
name: Jiang, Zhibin
name: Yuan, Biao
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Science Policy
Biological Sciences
Biotechnology

description: Home health care (HHC) is defined as providing medical and paramedical services for patients at their own domicile. In the HHC industry, it is crucial for health care organisations to assign caregivers to patients and devise reasonable visiting routes to save total operational cost and improve the service quality. However, some special constraints make the problem hard to solve. For example, patients’ service times are usually stochastic due to their varying health conditions; caregivers are organised in a hierarchical structure according to their skills to satisfy patients’ demands. In this paper, we address a HHC scheduling and routing problem with stochastic service times and skill requirements. A stochastic programming model with recourse is proposed to formulate the problem in which the expected penalty for late arrival at customers is considered. To solve the problem, it is equivalently transformed into a master problem and a pricing sub-problem. A column generation algorithm is developed to solve the relaxation of the master problem and obtain its lower bound. A label algorithm and several effective accelerating techniques are devised to solve the pricing sub-problem. To obtain feasible solutions, the column generation procedure is embedded within the branch and bound framework. The effectiveness of the proposed algorithm is validated through numerical experiments.
Design and testing of the NCTU micro-orifice cascade impactor (NMCI) for the measurement of nanoparticle size distributions
Creators: name: Chien, Chih-Liang
name: Tien, Chi-Yu
name: Liu, Chun-Nan
name: Ye, Huajun
name: Huang, Wei
name: Tsai, Chuen-Jinn
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Biophysics
subject: Plant Biology
subject: Biological Sciences
subject: Earth and Environmental Sciences
subject: Engineering

description: ABSTRACTThe NCTU micro-orifice cascade impactor (NMCI) was redesigned and tested to enable the measurement and adjustment of the jet-to-plate distance (S) of the impactors by using a micrometer. Each stage of the NMCI contains an impaction plate and a nozzle plate which are separated. The bottom casing for impaction plate assembly and the nozzle plate holder of each stage are separated. Calibration results show that the cutoff aerodynamic diameter (dpa50) of the three lower stages (dpa50 = 180, 100, and 56 nm) are close to the nominal values given in Marple et al. (1991). In addition, the S/W (W: nozzle diameter) effects on the dpa50 for the three lower stages were investigated and an empirical equation was developed to facilitate the prediction of dpa50 when the nozzle diameters may change slightly from one batch to another. The relationship between the nozzle diameter and pressure drop of the micro-orifice impactors at the fixed operational flow rate of 30 L/min was also established so that the nozzle diameters can be predicted from the pressure drop measurement. An empirical equation was proposed to express the correlation between the dimensionless cutoff size and the S/W ratio when considering isentropic flow to facilitate the design of micro-orifice impactors for S/W > 4. It is expected that the present NMCI could improve the accuracy of size-classification of submicron particles below 180 nm, especially for nanoparticles.