cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Advantages of Intermittent Flow Control Schemes on the Purdue Hog Cooling Pad for Mitigating Heat Stress in Lactating Sows
Creators: name: Field, Tyler C
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Agricultural engineering

description: The Purdue hog cooling pad has previously been demonstrated to adequately mitigate heat stress in lactating sows by conductively transferring heat from the sow to cold water running through the cooling pad. The cooling effectiveness describes how much heat is removed per liter of water flushed through the cooling pad. Past studies indicated that intermittent flow of the cooling water could achieve greater cooling effectiveness than continuous flow systems. An electronic control system was implemented on the current cooling pad design to allow for automated control of a solenoid valve based on a preprogrammed flush condition. The control schemes were categorized into two groups: temporal and temperature threshold. The temporal schemes opened the solenoid for 30 seconds before closing it for 3, 6, or 9 minutes. The temperature threshold control schemes utilized feedback from temperature probes embedded beneath the surface of the cooling pad to open the solenoid for 30 seconds when a surface temperature of at least 28.0C 29.5C, or 31.0C was detected. The temperature threshold control schemes achieved greater heat transfer rates (348, 383, 268 W) versus the temporal control schemes (324, 128, 84 W). The cooling effectiveness for all control schemes ranged from 46.6 to 64.7 kJ/L. Intermittent flow control schemes did achieve greater cooling effectiveness than continuous flow systems from previous studies, but they did so at lower heat transfer efficiencies.
sj-pdf-1-ijd-10.1177_10567895211036491 - Supplemental material for Anisotropic, rate-dependent ductile fracture of Ti-6Al-4V alloy
Creators: name: Ruiz de Sotto, Miguel
name: Doquet, Véronique
name: Longère, Patrice
name: Papasidero, Jessica
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: Supplemental material, sj-pdf-1-ijd-10.1177_10567895211036491 for Anisotropic, rate-dependent ductile fracture of Ti-6Al-4V alloy by Miguel Ruiz de Sotto, Véronique Doquet, Patrice Longère and Jessica Papasidero in International Journal of Damage Mechanics
Additional file 1 of Genotype variation of ACE and ACE2 genes affects the severity of COVID-19 patients
Creators: name: Faustine, Ingrid
name: Marteka, Deli
name: Malik, Amarila
name: Supriyanto, Eko
name: Syafhan, Nadia F.
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Virology
subject: Computational Biology

description: Supplementary Material 1
Additional file 1 of Map-1a regulates Sertoli cell BTB dynamics through the cytoskeletal organization of microtubule and F-actin
Creators: name: Wang, Lingling
name: Yan, Ming
name: Bu, Tiao
name: Wu, Xiaolong
name: Li, Linxi
name: Silvestrini, Bruno
name: Sun, Fei
name: Cheng, C. Yan
name: Chen, Hao
Publisher: name: figshare
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: Supplementary Material 1.
Neural representations of natural speech in a chinchilla model of noise-induced hearing loss
Creators: name: Parida, Satyabrata
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Neurosciences not elsewhere classified
Biomedical engineering not elsewhere classified

description: Hearing loss hinders the communication ability of many individuals despite state-of-the-art interventions. Animal models of different hearing-loss etiologies can help improve the clinical outcomes of these interventions; however, several gaps exist. First, translational aspects of animal models are currently limited because anatomically and physiologically specific data obtained from animals are analyzed differently compared to noninvasive evoked responses that can be recorded from humans. Second, we lack a comprehensive understanding of the neural representation of everyday sounds (e.g., naturally spoken speech) in real-life settings (e.g., in background noise). This is even true at the level of the auditory nerve, which is the first bottleneck of auditory information flow to the brain and the first neural site to exhibit crucial effects of hearing-loss.
To address these gaps, we developed a unifying framework that allows direct comparison of invasive spike-train data and noninvasive far-field data in response to stationary and nonstationary sounds. We applied this framework to recordings from single auditory-nerve fibers and frequency-following responses from the scalp of anesthetized chinchillas with either normal hearing or noise-induced mild-moderate hearing loss in response to a speech sentence in noise. Key results for speech coding following hearing loss include: (1) coding deficits for voiced speech manifest as tonotopic distortions without a significant change in driven rate or spike-time precision, (2) linear amplification aimed at countering audiometric threshold shift is insufficient to restore neural activity for low-intensity consonants, (3) susceptibility to background noise increases as a direct result of distorted tonotopic mapping following acoustic trauma, and (4) temporal-place representation of pitch is also degraded. Finally, we developed a noninvasive metric to potentially diagnose distorted tonotopy in humans. These findings help explain the neural origins of common perceptual difficulties that listeners with hearing impairment experience, offer several insights to make hearing-aids more individualized, and highlight the importance of better clinical diagnostics and noise-reduction algorithms.
The Dynamics of Coupled Resonant Systems and Their Applications in Sensing
Creators: name: Pyles, Conor S
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Mechanical engineering not elsewhere classified
Circuits and systems
Dynamics, vibration and vibration control
Microtechnology

description: The field of coupled resonant systems is a rich research area with enumerable real-world applications, including the fields of neural computing and pattern recognition, energy harvesting, and even modeling the behavior of certain types of biological systems. This work is primarily focused on the study of the behaviors of two subsets of this field: large networks of globally coupled resonators (which, in this work, refers to passive, damped resonant elements which require external stimulus) and smaller networks of oscillators (referring to active devices capable of self-sustained motion), which are coupled through a network of light-sensitive resistive elements. In the case of the former, we begin by developing an analytical and experimental framework to examine the behaviors of this system under various conditions, such as different coupling modalities and element-level parametric mistunings. Once a proper understanding of the dynamics of these systems has been established, we go on to develop the system into a single-input, single-output, multi-analyte volatile organic compound sensor. For the study of oscillator networks, we begin by building a device which utilizes a network of Colpitts oscillators, coupled through a series of color-filtered CdSe photocells. We then establish that through the analysis of particular emergent behaviors (most notably, frequency locking within the network), this type of system may show promise as a threshold color sensor. By exploiting these behaviors, this type of system may find applications in neuromorphic computing (particularly in optical pattern recognition).
THE EFFECT OF FOLLOW UP TOCERANIB PHOSPHATE ON FELINE ORAL SQUAMOUS CELL CARCINOMAS TREATED WITH HYPERFRACTIONATED RADIATION AND CARBOPLATIN
Creators: name: Schlueter, Andrew H.
Publisher: name: Washington State University
Year: 2025
Subjects: Feline
Palladia
Squamous cell carcinoma
Oncology

description: Oral squamous cell carcinoma is the most common oral tumor in cats but treatment options that provide long term tumor control are limited. Radiation therapy is a reported treatment option, but local tumor control is still difficult to obtain, and additional treatment options are needed. Toceranib phosphate recently emerged as having biologic activity against feline oral squamous cell carcinoma but the mechanism of benefit is unknown. This non-blinded retrospective single institutional study included all patients between 2011 to 2023 that underwent accelerated radiation therapy with concurrent carboplatin as previously described with the exception of one additional dose of radiation, and once the early side effects abated, toceranib phosphate was initiated. The median survival time (MST) and progression free interval (PFI) were assessed for the cats that received toceranib and was compared to the cats that received the same radiation protocol within the same time period that did not receive toceranib.
description: Overall, 47 cats fit the criteria for all cats irradiated in the time period and 15 were included in the group that received toceranib. There was no significant difference in survival time or PFI between the cats that did and did not receive toceranib when all cats were considered. When comparing only the cats with lingual tumors the PFI was significantly longer in the cats who received toceranib than those that did not (142 days vs 104 days, respectively P= 0.045) but there was no difference in MST (197 days vs 147 days P= 0.15). Additionally, among the cats who received toceranib there were significant differences in PFI and MST based on the location of the tumor. This study suggests that there may be clinical benefit to administering follow up toceranib after radiation in cats with lingual squamous cell carcinomas and additional prospective studies are warranted.
sj-pdf-1-pic-10.1177_09544062211023117 - Supplemental material for Comparative investigations of cryo-treated and untreated inserts on machinability of AISI 1050 by using response surface methodology, ANOVA and Taguchi design
Creators: name: Baday, Şehmus
name: Ersöz, Onur
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 99999 Engineering not elsewhere classified
subject: FOS: Other engineering and technologies

description: Supplemental material, sj-pdf-1-pic-10.1177_09544062211023117 for Comparative investigations of cryo-treated and untreated inserts on machinability of AISI 1050 by using response surface methodology, ANOVA and Taguchi design by Şehmus Baday and Onur Ersöz in Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science
sj-pdf-1-pmj-10.1177_02692163211043209 – Supplemental material for ‘It was like taking an inner bath’: A qualitative evaluation of a collaborative advance care planning-approach
Creators: name: Pedrosa Carrasco, Anna J
name: Koch, Martin
name: Machacek, Teresa
name: Genz, Anna
name: Herzog, Svenja
name: Riera Knorrenschild, Jorge
name: von Blanckenburg, Pia
name: Seifart, Carola
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-1-pmj-10.1177_02692163211043209 for ‘It was like taking an inner bath’: A qualitative evaluation of a collaborative advance care planning-approach by Anna J Pedrosa Carrasco, Martin Koch, Teresa Machacek, Anna Genz, Svenja Herzog, Jorge Riera Knorrenschild, Pia von Blanckenburg and Carola Seifart in Palliative Medicine
Immunosuppressive effects of triptolide via interleukin-2/receptor signaling
Creators: name: Xiong, Ying
name: Yin, Yi
name: Kodithuwakku, Nandani Darshika
name: Lv, Jiagang
name: Wang, Juan
name: Ding, Yanxia
name: Chen, Jiao
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Triptolide (TP) has been confirmed to possess many beneficial functions including anti-inflammation and immunosuppression. The present study aimed to explore the potential involvement of IL-2/IL-2R pathway in the immunosuppressive activities of TP. Cultured CTLL-2 cells were utilized to evaluate the potential benefits of TP. Then cell viability was determined by CCK-8 assay, IFN-γ level by ELISA assay, Annexin V-FITC/PI double-staining and CD25 expression by flow cytometry, and protein expression by western blotting. Additionally, rhIL-2–driven lymphocytes following ConA activation were investigated. The interactions of TP with IL-2 and IL-2Rα were investigated by binding assays and molecular dynamics simulations. TP treatment attenuated IFN-γ level and cell viability in both rhIL-2–induced CTLL-2 cells and rhIL-2–driven splenic lymphocytes. TP treatment increased cellular apoptosis/necrosis and cleaved PARP-1 level, while suppressed c-Myc level in rhIL-2–induced CTLL-2 cells. Additionally, TP treatment reduced CD25 expression on CTLL-2 cell surface. Notably, the phosphorylation protein levels in IL-2R signaling pathways were inhibited by TP exposure prior to rhIL-2 stimulation. SPR and BLI assays verified TP that directly bound to rhIL-2 and rmIL-2Rα, respectively. Molecular simulations suggested that TP bound at the interface of IL-2 and IL-2Rα near the hydrophobic patch composed of F62, L92 on IL-2 and L23, I46, V139 on IL-2Rα, resulting in decreased binding free energy between IL-2 and IL-2Rα. These findings collectively emphasized that TP interfered IL-2/IL-2Rα interactions, down-regulated IL-2Rα expression, and inhibited IL-2R signaling pathways activation, thereby leading to the immune cells being desensitized to rhIL-2 and exhibiting immunosuppressive properties.
Sirtinol, a SIRT1 inhibitor, inhibits the EMT and metastasis of 4T1 breast cancer cells and impacts the tumor microenvironment
Creators: name: Satam, Sharvari
name: Palekar, Nitya
name: Premkumar, Kavitha
name: Shankar, Bhavani S.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: The impact of epigenetic drugs on metastasis and the immunological microenvironment is poorly understood. In this study, we looked at how sirtinol, a SIRT1 inhibitor, affected epithelial-mesenchymal transition (EMT), metastasis, and the immune cells. In vitro experiments were carried out using tumor conditioned medium (TCM). For in vivo experiments, sirtinol was administered i.p. in tumor bearing BALB/c mice at a dose of 2 mg/kg body weight either alone or in combination with cisplatin. Estimation of cytokines was carried out using ELISA or ELIspot. Estimation of different markers was done using flow cytometry or western blot. Sirtinol, a SIRT1 inhibitor, was found to be cytotoxic to 4T1 breast cancer cells with no synergistic effects with cisplatin, both under in vitro and in vivo conditions (p < 0.05). Sirtinol significantly reduced cancer cell metastasis to the spleen which was supported by in vitro findings such as decreased vimentin expression and cell mobility in migration and wound healing assays (p < 0.01). Studies on the effects of 4T1 tumor-conditioned medium on spleen cells indicated changes in T cell proliferation as well as differentiation (p < 0.01). In tumor bearing mice, spleen cells showed elevated IFN-γ secretion, increased CD11b+ cells, and decreased T cells (p < 0.01). This was reversed by sirtinol as well as the combination treatment, which may also have contributed to metastasis inhibition (p < 0.01). Sirtinol, a SIRT1 inhibitor inhibits EMT and metastasis of 4T1 breast cancer cells and also has an impact on the immune microenvironment.
Advances in MINLP for Optimal Distillation Column Sequencing
Creators: name: Gooty, Radhakrishna Tumbalam
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Chemical engineering not elsewhere classified

description: Designing configurations for multicomponent distillation, a ubiquitous process in chemical and petrochemical industries, is often challenging. This is because, as the number of components increases, the number of admissible distillation configurations grows rapidly and these configurations vary substantially in their energy needs. Consequently, if a method could identify a few energy-efficient choices from this large set of alternatives, it would be extremely attractive to process designers. Towards this, we develop the first mixed-integer nonlinear programming (MINLP) based solution approach that successfully identifies the most energy-efficient distillation configuration for a given separation. Current sequence design strategies are largely heuristic. The rigorous approach presented here can help reduce the significant energy consumption and consequent greenhouse gas emissions by separation processes. In addition to the combinatorial complexity, the challenge in solving this problem arises from the nonconvex fractional terms contained in the governing equations. We make several advances to enable solution of these problems.
(1). We propose a novel search space formulation by embedding convex hulls of various important substructures. We prove that the resulting formulation dominates all the prior formulations in the literature.
(2). We derive valid cuts to the problem by exploiting the monotonic nature of the governing equations.
(3). We adapt the classical Reformulation-Linearization Technique (RLT) for fractional terms. Our RLT variant exploits the underlying mathematical structure of the governing equation, and yields a provably tighter convex relaxation.
(4). We construct the simultaneous hull of multiple nonlinear terms that are constrained over a polytope obtained by intersecting a hypercube with mass balance constraints. This yields a tighter convex relaxation than the conventional approach where the nonlinear terms are convexified individually over a box.
(5). A key challenge in constructing a valid convex relaxation has been that the denominator of certain fractions in the governing equation can approach arbitrarily close to zero. Using our RLT variant, we construct the first valid relaxation.
(6). We leverage powerful mixed-integer programming (MIP) solvers by implementing a discretization-based solution procedure with an adaptive partitioning scheme.
With extensive computational experiments, we demonstrate that the proposed approach outperforms the state-of-the-art in the literature. The formulation can be tailored to other objectives by appending the relevant constraints. Here, we present an extension that identifies the distillation configuration that has the highest thermodynamic efficiency. Finally, we illustrate the practicality of the developed approaches with case studies on crude fractionation and natural gas liquid recovery.
Enhancing the predictive power of molecular dynamics simulations to further the Materials Genome Initiative
Creators: name: Desai, Saaketh
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Theory and design of materials

description: Accelerating the development of novel materials is one of the central goals of the Materials Genome Initiative and improving the predictive power of computationalmaterial science methods is critical to attain this goal. Molecular dynamics (MD) is one such computational technique that has been used to study a wide range of materials since its invention in the 1950s. In this work we explore some examples of using and increasing the predictive power of MD simulations to understand materials phenomena and provide guidelines to design tailored materials. We first demonstrate the use of MD simulations as a tool to explore the design space of shape memory alloys, using simple interatomic models to identify characteristics of an integrated coherent second phase that will modify the transformation characteristics of the base shape memory alloy to our desire. Our approach provides guidelines to identify potential coherent phases that will achieve tailored transformation temperatures and hysteresis.
We subsequently explore ideas to enhance the length and time scales accessible via MD simulations. We first discuss the use of kinetic Monte Carlo methods in MD simulations to predict the microstructure evolution of carbon fibers. We ?find our approach to accurately predict the transverse microstructures of carbon fibers, additionally predicting the transverse modulus of these fibers, a quantity difficult to measure via experiments. Another avenue to increase length and time scales accessible via MD simulations is to explore novel implementations of algorithms involved in machine-learned interatomic models to extract performance portability. Our approach here results in significant speedups and an efficient utilization of increasingly common CPU-GPU hybrid architectures.
We finally explore the use of machine learning methods in molecular dynamics, specifically developing machine learning methods to discover interpretable laws directly from data. As examples, we demonstrate the discovery of integration schemes for MD simulations, and the discovery of melting laws for perovskites and single elements. Overall, this work attempts to illustrate how improving the predictive capabilities of molecular dynamics simulations and incorporating machine learning ideas can help us design novel materials, in line with the goals of the Materials Genome Initiative.
A Novel Data-Driven Design Paradigm for Airline Disruption Management
Creators: name: Ogunsina, Kolawole
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Aerospace engineering not elsewhere classified

description: Airline disruption management traditionally seeks to address three problem dimensions: aircraft scheduling, crew scheduling, and passenger scheduling, in that order. However, current efforts have, at most, only addressed the first two problem dimensions concurrently and do not account for the propagative effects that uncertain scheduling outcomes in one dimension can have on another dimension. Uncertainties in scheduling outcomes originate from random disruption events (like inclement weather and aircraft malfunction), the order in which the events occur, and how they are resolved. As such, these uncertainties propagate through all problem dimensions for airline disruption management on the day of operation.
In addition, existing approaches for airline disruption management include human specialists who decide on necessary corrective actions for airline schedule disruptions on the day of operation. However, human specialists are limited in their ability to process copious amounts of information imperative for making robust decisions that simultaneously address all problem dimensions during disruption management. Therefore, there is a need to augment the decision-making capabilities of a human specialist with quantitative and qualitative tools that can rationalize complex interactions amongst all dimensions in airline disruption management, and provide objective insights to the specialists in the Airline Operations Control Center (AOCC). To that effect, this dissertation provides a discussion and demonstration of an agnostic and systematic paradigm for enabling simultaneously-integrated recovery of all problem dimensions during airline disruption management, through an intelligent multi-agent system that employs principles from artificial intelligence and distributed ledger technology.
Vinpocetine attenuates 5-fluorouracil-induced intestinal injury: role of the Keap1/Nrf2/HO-1, NF-κB/TLR4/SOCS3 and RIPK1/RIPK3/MLKL signals
Creators: name: Hassanein, Emad H. M.
name: Althagafy, Hanan S.
name: Mansour, Sherif M. A.
name: Omar, Zainab M. M.
name: Hassanein, Mohamed Mahmoud Hussein
name: El-Ghafar, Omnia A. M. Abd
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: 5-Fluorouracil (5-FU) is a chemotherapy drug commonly prescribed in cancer management. Unfortunately, intestinal mucositis restricts 5-FU clinical use. Vinpocetine (VNP) is a synthetic alkaloid that is derived from vincamine. Our study was conducted to elucidate the intestinal protective effects of VNP on 5-FU intestinal injury in rats and explore the underlying mechanisms. 5-FU was injected i.p. for five days, while VNP was given P.O (5 and 10 mg/kg). VNP effectively mitigates oxidative stress by a significant increase in GSH and SOD and decreasing MDA content mediated by Nrf2, HO-1 upregulation, and significant Keap1 downregulation. VNP mitigated inflammatory perturbations by decreasing MPO, TNF-α, IL-1β, and IL-6 facilitated by downregulating NF-κB and TLR4 and upregulating SOCS3 levels. In addition, the RIPK1, RIPK3, MLKL, and caspase-8 expression levels were significantly decreased, evidenced improvement of intestinal necroptosis by VNP. Hence, VNP potently prevents intestinal injury induced by 5-FU by modulating Keap1/Nrf2/HO-1, NF-κB/TLR4/SOCS3, and RIPK1/RIPK3/MLKL signals.
Additional file 1 of Validation of graph sequence clusters through multivariate analysis: application to Rovash scripts
Creators: name: Hosszú, Gábor
Publisher: name: figshare
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Application of various hierarchical clustering methods to the inscriptions using different dissimilarity measures.
Additional file 1 of Addition of inflammation-related biomarkers to the CAIDE model for risk prediction of all-cause dementia, Alzheimer’s disease and vascular dementia in a prospective study
Creators: name: Trares, Kira
name: Wiesenfarth, Manuel
name: Stocker, Hannah
name: Perna, Laura
name: Petrera, Agnese
name: Hauck, Stefanie M.
name: Beyreuther, Konrad
name: Brenner, Hermann
name: Schöttker, Ben
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Supplementary Material 1.
Clinical features, treatment, and outcome of nivolumab-induced cholangitis
Creators: name: He, Yang
name: Fan, Zhiqiang
name: Sun, Wei
name: Ouyang, Linqi
name: Wang, Chunjiang
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Virology

description: Cholangitis is an uncommon and severe adverse reaction of nivolumab with unclear clinical features. The purpose of this study was to investigate the clinicopathological features, imaging, and treatment of nivolumab-induced cholangitis. Case reports, case series, and clinical studies of nivolumab-induced cholangitis were retrospectively analyzed by searching Chinese and English databases from January 1, 2017 to December 31, 2023. Thirty-eight patients entered the study. The median number of cycles of cholangitis onset was seven cycles after administration (range 1, 28) and the median time was 11 days (range 78, 390). Abdominal pain (42.1%) and fever (18.4%) were the most important initial symptoms. Some patients (15.8%) showed elevated liver enzymes without any clinical symptoms. The median alkaline phosphatase level was 1721 IU/L (range 126, 9118), and the median γ-glutamyltranspeptidase level was 829 IU/L (range 104, 3442). Anti-nuclear antibodies, anti-mitochondrial antibodies, and IgG4 typically show negative results. Imaging shows extrahepatic bile duct and intrahepatic bile duct dilation, hypertrophy, and stenosis. Liver biopsy and biliary tract biopsy mainly found CD8 inflammatory cell infiltration. Systemic steroids (84.2%) and ursodeoxycholic acid (UDCA) (34.2%) were administered, and 24 patients (63.2%) had poor to moderate response to steroids. Thirty-one patients (81.6%) improved and seven patients (18.4%) did not improve. Clinicians must remain vigilant for patients experiencing cholestasis while on nivolumab and should assess for cholangitis and carry out appropriate imaging tests. Considering the excellent efficacy of UCDA in cholangitis, steroids combined with UDCA may be a viable treatment option in cases where steroids are ineffective for cholangitis.
sj-pdf-1-ggm-10.1177_23337214211032055 – Supplemental Material for Clinical Questions Asked by Long-Term Care Providers Through eConsult: A Retrospective Study
Creators: name: Fung, Celeste
name: Shah, Soha
name: Helmer-Smith, Mary
name: Levi, Cheryl
name: Keely, Erin
name: Liddy, Clare
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine

description: Supplemental Material, sj-pdf-1-ggm-10.1177_23337214211032055 for Clinical Questions Asked by Long-Term Care Providers Through eConsult: A Retrospective Study by Celeste Fung, Soha Shah, Mary Helmer-Smith, Cheryl Levi, Erin Keely and Clare Liddy in Gerontology and Geriatric Medicine
Additional file 2 of A nomogram based on biparametric magnetic resonance imaging for detection of clinically significant prostate cancer in biopsy-naïve patients
Creators: name: Hu, Beibei
name: Zhang, Huili
name: Zhang, Yueyue
name: Jin, Yongming
Publisher: name: figshare
Year: 2024
Subjects: Space Science
Medicine
Cell Biology
Biotechnology
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Supplementary Material 2
sj-pdf-1-aor-10.1177_00034894211042772 – Supplemental material for Laryngotracheobronchial Amyloidosis: Patterns of Presentation and Management
Creators: name: Dermody, Sarah M.
name: Campagnaro, Erica L.
name: Kupfer, Robbi A.
name: Hogikyan, Norman D.
name: Morrison, Robert J.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110315 Otorhinolaryngology
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-1-aor-10.1177_00034894211042772 for Laryngotracheobronchial Amyloidosis: Patterns of Presentation and Management by Sarah M. Dermody, Erica L. Campagnaro, Robbi A. Kupfer, Norman D. Hogikyan and Robert J. Morrison in Annals of Otology, Rhinology & Laryngology
Additional file 1 of Identifying changes in dynamic plantar pressure associated with radiological knee osteoarthritis based on machine learning and wearable devices
Creators: name: Li, Gege
name: Li, Shilin
name: Xie, Junan
name: Zhang, Zhuodong
name: Zou, Jihua
name: Yang, Chengduan
name: He, Longlong
name: Zeng, Qing
name: Shu, Lin
name: Huang, Guozhi
Publisher: name: figshare
Year: 2024
Subjects: subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences

description: Additional file 1: Method S1. Methods to calculate dynamic plantar pressure. Table S1. Description of modified Kellgren–Lawrence grade. Table S2. 210 dynamic plantar pressure features. Fig. S1. Optimal features selection
Efficacy and safety of combining radiotherapy with immune checkpoint inhibitors in patients with advanced non-small cell lung cancer: a real-world study
Creators: name: Yang, Guanli
name: Zhou, Zhen
name: Liu, Chengxin
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Science Policy

description: The significance of local radiotherapy (RT) in advanced non-small-cell lung cancer (NSCLC) is well documented. However, the advent of immunotherapy has raised questions regarding the synergistic survival benefits or potential adverse effects. This study aimed to explore whether a combination of RT and systematic immune checkpoint inhibitors (ICIs) can improve the survival outcomes for NSCLC patients. Based on collected data patients who received RT were defined as the RT group, and those who had not for any site were defined as the non-RT group. Propensity score matching (PSM) was employed to mitigate bias. The primary endpoint was progression-free survival (PFS), with secondary endpoints including overall survival (OS) and treatment-related adverse events (AEs). Out of 709 patients (235 in RT group and 474 in non-RT group) were included, with 213 patients per group. The median PFS of the RT group was better than that of the non-RT group (13.8 months versus 9.5 months; p < 0.0001), although no superiority in median overall survival (OS) of the RT group was observed (p = 0.715). However, among the cohort of patients with ≤3 metastases, the median OS of the RT group improved significantly (HR = 0.60, [95% CI 0.44–0.83]; p = 0.004). Treatment-related AEs occurred in 94.5% of RT group patients and in 94.9% of non-RT group patients (p = 0.792), which indicated no observable increase in AEs from RT. These results demonstrate the tolerability of RT when administered along with immunotherapy, suggesting its potential to positively impact the survival outcomes of NSCLC patients.
title: The Interface is Obsolete: A Critical Investigation of the Digital interface in Interactive New Media Installations
Creators: name: Shanbaum, Phaedra
Publisher: name: Goldsmiths, University of London
Year: 2017
Subjects: subject: Interface, Interface Criticism, Art and Technology, Digital Media Art, Interactive New Media Installations

description: My thesis proposes a critical framework for understanding the digital interface in interactive
new media installations. I aim at dispelling the instrumental, cybernetic, “action-reaction”
myth that surrounds the functions of the interface and that constitutes one of the main
limitations in its conceptualization today. I argue that a rethinking of the digital interface in
terms of its aesthetic and cultural properties is essential if we are to take digital interfaces
seriously as devices that inform or even, to some extent, structure our relationship with
technology.

Theorists who work in the interdisciplinary field of interface studies have historically been
preoccupied with the technical and instrumental functions the interface performs –
specifically with how it acts and reacts to pre-programmed information. To do this, they have
predominantly drawn on computer science and engineering perspectives. Thus digital
interfaces have commonly been understood as the symbolic software that enables humans to
use computers. My thesis approaches the digital interface from a different direction,
concentrating on the aesthetic and cultural aspects of the digital interface, and drawing on
scholarship from the fields of art history and media studies. In particular, I focus on critically
examining how various interfaces are defined within art environments and how they
influence the way subjects, objects, and the relationships and processes that exist between
them are understood in these disciplinary fields and practices. Throughout, I propose a more
expansive definition of the digital interface in interactive new media installations, positioning
it as a dynamic, hybrid, aesthetic and cultural process. I thus reformulate the problem of the
digital interface as a problem of making the often invisible aspects of the device legible.

Ultimately, I argue that the interface mediates, thus creates, to an extent, relationships
between viewer/participants, artists and artworks as well as influences the movements and
perceptions of those interacting with it. This reading enables me to conclude that the digital
interface can be seen as an important actor in positioning and (re)shaping specific ways in
which the self relates to technology, to artistic practice and to other human and nonhuman
beings in the current media culture. At the heart of this thesis is the notion that the digital
interface matters and that a critical exploration of it in aesthetic contexts can help us
understand and possibly reconfigure our human relationship with technology.
sj-pdf-2-pmj-10.1177_02692163211042999 – Supplemental material for Navigating the caregiving abyss: A metasynthesis of how family caregivers manage end-of-life care for older adults at home
Creators: name: Michaels, Jacqueline
name: Chen, Chiahui
name: Ann Meeker, Mary
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-2-pmj-10.1177_02692163211042999 for Navigating the caregiving abyss: A metasynthesis of how family caregivers manage end-of-life care for older adults at home by Jacqueline Michaels, Chiahui Chen and Mary Ann Meeker in Palliative Medicine
AN EVOLUTIONARY GENOMICS STUDY FOR CONSERVATION OF THE MONTEZUMA QUAIL
Creators: name: Mathur, Samarth
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Evolutionary biology not elsewhere classified
Genomics
Molecular evolution
Anthropological genetics
Genetics not elsewhere classified
Behavioural genetics

description: Humans have altered natural landscape since the agricultural revolution, but it has been most destructive since human globalization and rampant industrialization in the last two centuries. These activities deteriorate and fragments natural habitat of many wild species that creates small isolated populations that lose genetic diversity over time. Loss of genetic diversity reduces the adaptive capacity of a population to respond to future environmental change and increases their extinction risks. Implementing strategies for wildlife conservation is a challenge primarily because of our lack of understanding of the biology of many wild species, the risks they are currently facing, and their evolutionary histories. With the advent of genomic and computational techniques, it is now possible to address these concerns. In my research, I used genomics to study the evolutionary history of the Montezuma Quail (Cyrtonyx montezumae) and created monitoring tools that can be readily applied by wildlife managers for its conservation. Montezuma Quail is a small gamebird found mostly in Mexico with peripheral populations existing in Arizona, New Mexico, and Texas. Montezuma Quail are going through species wide decline in the United States and are listed as vulnerable in the state of Texas due to their small population sizes and geographic isolation from rest of the range. My results show that Texas quail are genetically distinct and significantly less diverse than Arizona quail. Analysis of whole genome sequences from multiple individuals show that due to small population sizes and isolation, Texas quail are significantly more inbred and genetic drift is the major contributor for loss of genetic diversity we see today. Inbreeding is negatively impacting Texas quail as they carry more deleterious alleles within their genome that reduce fitness of the individuals. Demographic models predict that both Arizona and Texas populations were formed via founding bottlenecks around 20,000 years ago. Texas populations have maintained small population sizes since its split from the ancestral populations and are less efficient in purging new deleterious mutations that arise post-bottleneck. The inferences from my research not only carries direct implications for Montezuma Quail conservationists, but also illustrate the power of evolutionary genomics in implementing targeted management strategies for any species that face existential threats in today’s waning world.
sj-pdf-2-pmj-10.1177_02692163211037480 – Supplemental material for End of life care for people with severe mental illness: Mixed methods systematic review and thematic synthesis (the MENLOC study)
Creators: name: Edwards, Deborah
name: Anstey, Sally
name: Coffey, Michael
name: Gill, Paul
name: Mann, Mala
name: Meudell, Alan
name: Hannigan, Ben
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 110308 Geriatrics and Gerontology
subject: FOS: Clinical medicine
subject: 111702 Aged Health Care
subject: FOS: Health sciences

description: Supplemental material, sj-pdf-2-pmj-10.1177_02692163211037480 for End of life care for people with severe mental illness: Mixed methods systematic review and thematic synthesis (the MENLOC study) by Deborah Edwards, Sally Anstey, Michael Coffey, Paul Gill, Mala Mann, Alan Meudell and Ben Hannigan in Palliative Medicine
Online Training as a Means to Improve the Understanding of Ethical, Legal, and Social Aspects of Biobanking Research: Stakeholder Perspectives from South Africa
Creators: name: Cadigan, Rosemary Jean
name: Moodley, Keymanthri
name: Singh, Shenuka
Publisher: name: Mary Ann Liebert
Year: 2021

description:
Introduction: The proliferation of biobanking activities demand a review of current training opportunities for service providers and researchers, specifically related to the ethical, legal, and social issues (ELSI) of biobanking research. Such information could be useful for planning and developing an educational course. However, it is equally important to explore the platform for offering such a course. Aim and Objectives: This study explored stakeholder perspectives on training needs in biobanking research and the use of an online training platform for such educational purposes. Methods: An exploratory study design using qualitative data was used. The study sample comprised selected stakeholders (n = 25) including biobankers, clinicians, researchers, postgraduate students, and research ethics committee members. Semi-structured in-person or Skype interviews were conducted and all ethical considerations were upheld. The interview focused on participants' perspectives on the accessibility and applicability of current available courses, and advantages and disadvantages of online biobanking courses. Data were analyzed using thematic analysis. Results and Discussion: The following themes arose from data analysis: inadequate availability of online courses, and advantages and disadvantages of online courses and opportunities for a successful training course. There was general consensus regarding the limited availability of context-specific training opportunities on the ELSI of biobanking. The majority of participants were previously self-taught and therefore relied on existing literature and collaborations with international biobanking groups for ongoing learning. Some respondents indicated that the costs of such available training courses were exorbitant. Some respondents also felt that available courses were not tailored to the specific needs of a diverse audience in biobanking. Apart from access, respondents reported possible challenges with internet connectivity and availability of data. Conclusion: Respondents expressed a need for affordable and focused online educational opportunities in biobanking, but highlighted that these courses need to be contextualized and integrated into other learning activities.
High-Speed Flow Visualization and IR Imaging of Pool Boiling on Surfaces Having Differing Dynamic Wettabilities
Creators: name: Vu, Nicholas Toan-Nang
Publisher: name: Purdue University Graduate School
Year: 2020
Subjects: Mechanical engineering not elsewhere classified
Computational methods in fluid flow, heat and mass transfer (incl. computational fluid dynamics)

description: Boiling is used in a wide variety of industries, including electronics cooling, distillation, and power generation. Fundamental studies on the boiling process are needed for effective implementation. Key performance characteristics of boiling are the heat transfer coefficient, which determines the amount of heat flux that can be dissipated for a given superheat, and critical heat flux(CHF), the failure point that occurs when vapor blankets the surface. The wettability of a surface is one of the key parameters that affects boiling behavior. Wetting surfaces(e.g., hydrophilic surfaces), typically characterized by a static contact angle below 90°,have better critical heat flux due to effective rewetting, but compromised heat transfer coefficients due to increased waiting times between nucleation of each bubble. Meanwhile, nonwetting surfaces (e.g., hydrophobic surfaces), characterized by static contact angles greater than 90°, have better heat transfer coefficients due to improved nucleation characteristic, but reach critical heat flux early due to surface dry out. However, recent studies have shown that the static contact angle alone offers and incomplete, and sometimes inaccurate, description of this behavior, which is instead governed entirely by the dynamic wettability. Specifically, the receding contact angle impacts the size and contact area of bubbles forming on a surface during boiling, while the advancing contact angle determines how the bubble departs. With this more complete set of wettability descriptors, three characteristic wetting regimes define the boiling behavior: hygrophilic surfaces having advancing and receding contact angles both under 90°; hygrophobic surfaces having both these dynamic contact angles over 90°;and ambiphilic surfaces having a receding contact angle less than 90°, but an advancing contact angle greater than 90°.The goal of this thesis is to experimentally characterize and compare the behavior of boiling surfaces in each of these regimes, observe the contact line behavior, and explain the mechanisms for their differences in performance.