cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Mental Health Problems in Parole Decisions: The Re-conceptualization of Mental Health Problems as Risk Factors
Creators: name: Stewart, Shannon Marie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Mental health
DSM-5
conditional release
parole
detention
risk
the expert
medication compliance
corrections
symbolic interactionism
governmentality
decision-making theory

description: Deinstitutionalization has had an impact increasing the number of offenders with mental health problems within the correctional system. Furthermore, preliminary research claims that offenders with mental health problems are disproportionately denied when applying for parole. The reasons for this are not well understood. This exploratory qualitative research draws on 48 decisions from the Parole Board of Canada decision registry, four interviews with former parole board members, and observation data from 17 parole hearings to explore how mental health problems are constructed within the conditional release decision-making process. Against a risk logic back drop, this institutional ethnography analyzes the way parole board members understand and operationalize mental health within the decision-making process. Self-regulation, medication compliance, and the role of the expert were strong themes that emerged through a content analysis. By integrating symbolic interactionism and a governmentality framework, the current study explores how mental health in parole decision-making is influenced by individual, organizational, and macro-level risk rationalities that draw on neoliberal responsibilization strategies and "psy" expertise. The findings are presented within Hawkin’s (2002) legal decision-making framework. Policy and human rights implications are discussed.
Multi-actor cooperation models for NTM (network traffic management). First release
Creators: name: Franco, Daniel
name: Juliat, Morgane
Publisher: name: Zenodo
Year: 2024
Subjects: Multi-actor cooperation
arbitration models
data sharing
network traffic management
cooperative decision-making
data governance

description: The first release of D1.3 reports on the analysis of multi-actor cooperation models for innovative network traffic management (NTM), considering the system’s architecture and operation, to develop optimal cooperation models and provide recommendations towards effective governance structures for network traffic management in the TANGENT case studies cities.One of the key objectives of the TANGENT project is to propose multi-actor cooperation models for optimizing and controlling the dynamics of traffic and demand and adapting to the evolving complex multimodal transport setting with innovative network traffic management.Based on the literature review conducted in D5.1 “Analysis of current approaches in optimization of transport network management” related to negotiation and arbitration models for transport network management, this deliverable aims at identifying the case studies current multi-actor cooperation mechanisms in place and the ones that could be tested in TANGENT. It also reflects on data governance aspects of multi-actor cooperation, further developed in D2.2 “Data-sharing governance model”.
What is the Readiness of Registered Nurses Who Provide Care for Patients with Diabetes in a Primary Care Setting for Registered Nurse Prescribing?
Creators: name: MacKenzie, Shelley
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: RN prescribing
nurse prescribing

description: Objective: To determine the readiness of registered nurses (RNs) who provide care for patients with diabetes in a primary care setting for RN prescribing. Setting: Canadian provinces and territories. Participants: Canadian RNs working in primary care settings who provide care to patients with diabetes. Methods: A cross-sectional survey design was used to examine the readiness of RNs by measuring the attributes of readiness (value, confidence and willingness). The survey included questions on the demographic profile of participants including their age, education level and whether or not they had obtained additional certifications. This data was used to describe the sample and to determine whether there were differences between RNs who were ready to prescribe and RNs who were not ready to prescribe. Results: Almost 75% of the respondents were "ready" for RN prescribing. There were high positive correlations between "value" and "confidence", "value" and "willingness", and "confidence" and "willingness". There were no statistically significant differences in age, level of education and certifications for respondents who were ready to prescribe compared to those who were not ready to prescribe. Conclusions: The results of the present study indicate that RNs who provide care for patients with diabetes in a primary care setting are ready for prescribing. This practice has the potential to make more effective use of health human resources, allowing RNs to work to their full potential and increase accessibility to care for patients with diabetes.
Hemp-Lime Composite Integration with Phase Change Materials and their Application in Cold Climates
Creators: name: Abdellatef, Yaser
Publisher: name: Université d'Ottawa | University of Ottawa
Year: 2024
Subjects: Hempcrete
Phase change material
Energy storage
Hysteresis
Hemp-lime Composite
ANSYS Fluent
Energy Consumption
Numerical Analysis

description: This research explores developing, characterizing, and analyzing a new low-carbon composite material combining hemp-lime (hempcrete) and phase change materials (PCMs) for enhanced thermal performance in buildings. The study is divided into four main phases. In the first phase, novel hemp-lime composites were created using recycled, locally sourced, low-embodied energy binders and pozzolans. These composites were experimentally characterized for mechanical, thermal, and moisture buffering properties. Results showed that density affects hempcrete's properties and locally sourced pozzolans like metakaolin and recycled brick performed better than traditional hydraulic lime. The second phase included developing new hemp-lime composites with metakaolin and microencapsulated PCMs (MPCM). Numerical simulations compared the energy performance of timber-frame walls with hempcrete and HPCMs. The inclusion of MPCMs enhanced the heat storage potential of the composites. Consequently, in the third phase, a novel hysteresis modelling approach was proposed to improve the accuracy of phase change simulations. The new model was validated experimentally and compared with existing hysteresis methods. The study highlighted the importance of selecting appropriate hysteresis models and PCM integration techniques. Finally, numerical simulations investigated the effect of different heating schedules on hempcrete-PCM wall assemblies. The scenarios tested included heating setback temperature and temperature ramp-up. Results indicated that changing setpoints significantly influences PCM behaviour and wall thermal performance. Overall, this research demonstrates the potential of PCM-enhanced hemp-lime composites as sustainable building materials with improved thermal mass capacity suitable for cold climates like Canada.
PSR J2234+0611: A new laboratory for stellar evolution
Creators: name: Stovall, K.
name: Freire, P. C. C.
name: Antoniadis, J.
name: Bagchi, M.
name: Deneva, J. S.
name: Garver-Daniels, N.
name: Martinez, J. G.
name: McLaughlin, M. A.
name: Arzoumanian, Z.
name: Blumer, H.
name: Brook, P. R.
name: Cromartie, H. T.
name: Demorest, P. B.
name: DeCesar, M. E.
name: Dolch, T.
name: Ellis, J. A.
name: Ferdman, R. D.
name: Ferrara, E. C.
name: Fonseca, E.
name: Gentile, P. A.
name: Jones, M. L.
name: Lam, M. T.
name: Lorimer, D. R.
name: Lynch, R. S.
name: Ng, C.
name: Nice, D. J.
name: Pennucci, T. T.
name: Ransom, S. M.
name: Spiewak, R.
name: Stairs, I. H.
name: Swiggum, J. K.
name: Vigeland, S. J.
name: Zhu, W. W.
Publisher: name: Swinburne
Year: 2024

description: We report the timing results for PSR J2234+0611, a 3.6 ms pulsar in a 32 day, eccentric (e = 0.13) orbit with a helium white dwarf. The precise timing and eccentric nature of the orbit allow measurements of an unusual number of parameters: (a) a precise proper motion of 27.10(3) mas yr-1 and a parallax of 1.05(4) mas resulting in a pulsar distance of 0.95(4) kpc; enabling an estimate of the transverse velocity, 123(5) km s-1. Together with previously published spectroscopic measurements of the systemic radial velocity, this allows a 3D determination of the system's velocity; (b) precise measurements of the rate of advance of periastron yields a total system mass of 1.6518 +0.0033
 -0.0035 M o; (c) a Shapiro delay measurement, h 3 = 82 ±14 ns, despite the orbital inclination not being near 90°; combined with the measurement of the total mass yields a pulsar mass of and a companion mass of (d) we measure precisely the secular variation of the projected semimajor axis and detect a significant annual orbital parallax; together these allow a determination of the 3D orbital geometry of the system, including an unambiguous orbital inclination (i = 138.7+2.5
 -2.2 deg) and a position angle for the line of nodes (ω = 44+5
 -4 deg). We discuss the component masses to investigate the hypotheses previously advanced to explain the origin of eccentric MSPs. The unprecedented determination of the 3D position, motion, and orbital orientation of the system, plus the precise pulsar and WD masses and the latter's optical detection make this system a unique test of our understanding of white dwarfs and their atmospheres.
Childhood Maltreatment, Negative Self-Referential Processing, and Depressive Symptoms During Stress
Creators: name: Jopling, Ellen
name: Tracy, Alison
name: LeMoult, Joelle
Publisher: name: Dove Medical Press
Year: 2022

description: Introduction: Researchers have documented that the impact of childhood maltreatment on later symptoms of depression differs depending on the type(s) of maltreatment experienced, with emotional abuse and neglect being more likely than other forms of childhood maltreatment to increase the risk for depression. It is possible that emotional abuse and neglect are more likely to increase the risk for depression because they promote the development of negative selfreferential processing (SRP), but this has not yet been tested empirically. The current study was designed to examine whether negative SRP mediated the association between different forms of childhood maltreatment and symptoms of depression during a time of stress. Methods: We assessed the experience of different forms of childhood maltreatment (ie, emotional neglect, physical neglect, emotional abuse, physical abuse, and sexual abuse) and negatively biased self-schemas early on in the university semester, among a sample of undergraduate students. We then assessed levels of depressive symptoms 2 months later during a naturalistic stressor (ie, university students’ first final exams). Results: As expected, negative SRP mediated the relation between both neglect and emotional abuse, but not physical and sexual abuse, and later symptoms of depression. Discussion: This is the first study to examine SRP as a mechanism underlying the association between forms of childhood maltreatment and symptoms of depression during a time of stress. Results suggest that the development of negative SRP biases may explain why some types of childhood maltreatment are more likely than others to increase an individual’s risk for depression during stressful developmental periods.
Esaguasu ocularis Galileo & Martins, 2007, sp. nov.
Creators: name: Galileo, Maria Helena M.
name: Martins, Ubirajara R.
Publisher: name: Zenodo
Year: 2007
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Cerambycidae
Esaguasu
Esaguasu ocularis

description: Esaguasu ocularis sp. nov.
(Fig. 9)
Tegumento corporal preto com áreas mais avermelhadas. Antenas e pernas preto-avermelhadas. Cabeça com faixa de pubescência amarelada atrás dos olhos. Antenas atingem o ápice elitral na base do antenômero IX. Lados do protórax com faixa longitudinal de pubescência branco-amarelada. Pronoto densamente pontuado no centro; os pontos se anastomosam e chegam a constituir rugosidades transversais. Cada élitro com três áreas irregulares, revestidas por pubescência amarelo-esbranquiçada: uma lateral, do úmero ao meio, outra lateral no terço apical e uma sutural que envolve as extremidades menos os espinhos.
 Dimensões, em mm, holótipo macho: Comprimento total, 13,5; comprimento do protórax, 2,7; maior largura do protórax, 3,4; comprimento dos élitros, 9,5; largura umeral, 4,0.
 Material-tipo: Holótipo macho, COLÔMBIA, Amazonas: Parque Natural Nacional Amacayacu (Mata Mata, 3°23’S, 70°6’W, 150 m), 2-11.IV.2000, A. Parente col. (IAHC).
description: Published as part of Galileo, Maria Helena M. & Martins, Ubirajara R., 2007, Descrições de táxons em Hippopsini, Desmiphorini e Pteropliini (Cerambycidae, Lamiinae), pp. 349-357 in Papéis Avulsos de Zoologia 47 (25) on pages 356-357, DOI: 10.1590/S0031-10492007002500001, http://zenodo.org/record/13236463
"They Told Me to Shut Up and Stop Denying What I Am": On Claims of Asylum, Nigerian Women Fleeing Witchcraft-Motivated Violence and Intersecting Canadian Structures of Othering
Creators: name: Paul, Margaret Doreen O'Sullivan
Publisher: name: Université d'Ottawa | University of Ottawa
Year: 2024
Subjects: Immigration
Witchcraft
Gender-based violence

description: According to existing literature, English-speaking countries that receive refugees fleeing witchcraft-motivated violence see claims of asylum from Nigerian women more than from any other nation. Witchcraft-motivated violence is a gender-based issue that occurs in various forms in countries all over the world, and occurs when an individual, especially a woman, is accused of witchcraft and experiences violence as a result. Research in the sphere of witchcraft-motivated violence and asylum-seeking focuses on the context of international refugee law, particularly with regard to belonging to a 'particular social group.' This thesis aims to expand upon existing literature by focusing exclusively on decisions from Canada's Refugee Appeal Division. Through conducting a thematic content analysis of five cases of Nigerian women seeking asylum in Canada between 2019 and 2020, I demonstrated how intersecting Canadian structures of oppressive 'Othering' led to immigration decision-makers arriving at different conclusions about the lived realities of witchcraft-motivated violence than those presented by the women. I attribute these intersecting structures of Othering to a combination of what Said observed in his work Orientalism and Western social constructions of witchcraft and witch hunts rooted in misogyny. The importance of these findings contributed to the knowledge production in the sphere of witchcraft-motivated violence and asylum seeking, and highlights fundamental issues within the culture of the Refugee Appeal Division, and the Immigration and Refugee Board more broadly.
What does wellbeing mean? Perspectives of wellbeing among young people and youth workers in rural Victoria
Creators: name: Bourke, Lisa
name: Geldens, Paula
Publisher: name: Swinburne
Year: 2024

description: Well being is a well used but ill defined term in youth research. This paper describes research that explored the ways in which young people and youth workers define well being. The findings suggest that both groups agreed that well being was a multidimensional concept. However, the young people were more likely to consider well being to be influenced by individual factors, such as the state of their relationships, while the youth workers were more likely to emphasise the importance of structural factors. The different focuses of young people and youth workers may mean that each group works toward different but not necessarily contradictory goals. In fact, the goals may compliment each other.
The professionalization of history in English Canada to the 1950s.
Creators: name: Wright, Donald A.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: History, Canadian.

description: In opposition to the historiography which plots the rise of a historical profession in tum-of-the-century English Canada, this thesis argues that to think in terms of a rise from amateur history to professional history obscures more than it clarifies. Instead, it plots a different trajectory. Owing to the demands of an increasingly modern, urban and industrial society, intellectual life was transformed. In other words, one way of organizing intellectual life yielded to another way of organizing intellectual life. Whereas the nineteenth-century historian was a generalist for whom the study of the past was a part-time activity, the twentieth-century historian was a specialist for whom the study of the past was a full-time career. However, at the same time as there were changes in the practice of history, there were also important continuities. Against this backdrop, this thesis argues that while pre-professional historians could write hagiographic and patriotic books and articles, they also practised some of the techniques associated with professional history: archival research, historiography and the weighing of evidence. Moreover, women could be, and indeed were, historians when history was a part-time activity. Beginning with George Wrong's 1892 appointment to the University of Toronto, history began its migration into universities across English Canada. In addition, the Canadian Historical Review was launched in 1920; the Canadian Historical Association was founded in 1922; and graduate programmes were instituted. Historians also pursued a variety of professional strategies, including the drawing and policing of boundaries between who could and could not be a historical knower. Boundary-work was a gendered process. Whereas women were historians when history was understood as a past-time, they were excluded from the historical project when it was understood as a career. In this sense, the professionalization of history also saw its masculinization. Central to any professional project is the defence of independence. To study the defence of professional autonomy, this thesis examines the many relationships English-Canadian historians had with American philanthropy. In the absence of Canadian granting agencies, historians were forced to rely on American foundations for subventions to research and publication. Although the Carnegie Endowment for International Peace and the Rockefeller Foundation had their own research objectives, at the end of the day English-Canadian historians successfully pursued their own research agendas. In the crisis of World War II and the Cold War, professional historians began to re-think the historical project. Abandoning history as a practical social science, they returned to an older notion of history as a humanity concerned with questions about human values.
Ensuring effective protection against ELF adverse effect: the Australian experience
Creators: name: Wood, Andrew
Publisher: name: Swinburne
Year: 2024

description: A recent Environmental Health Criteria (EHC) monograph on Extremely Low Frequency fields (ELF) involved health risk assessment [1]. It recommended that exposure limits were needed to protect against certain established acute effects which could lead to adverse health. It noted the evidence for long-term low-intensity exposure being associated with increased risk of childhood leukaemia for average time-weighted exposure above 0.3 – 0.4 μT, but considered that the evidence was insufficiently strong to be considered causal. However, because of this evidence, procedures for implementing very low-cost precautionary procedures for reducing exposure were considered to be warranted. The Australian radiation protection agency, ARPANSA, commenced revision of 50/60 Hz guidelines, to encompass the 0 – 3 kHz frequency range, in 2002. The drafting committee considered local and international expert input as well as from stakeholders. The rationale behind the public consultation draft is reviewed in this paper. To protect against established effects, Basic Restrictions were derived by reassessing the literature, including the more recent data from MRI studies. Reference Levels were then derived making use of recent voxel-based models of male and female humans. A requirement for considering low-cost precautionary measures was included, with an annex discussing the form that these measures could take.
Supplementary document for Analysis and optimization of light outcoupling in OLEDs with external hierarchical textures - 5198201.pdf
Creators: name: Kovacic, Milan
name: Samigullina, Dinara
name: Bouchard, Felix
name: Krc, Janez
name: Lipovsek, Benjamin
name: Soldera, Marcos
name: Lasagni, Andrés
name: Reineke, Sebastian
name: Topic, Marko
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplementary information
Seismic evaluation and retrofit of existing reinforced concrete bridge columns.
Creators: name: Yalcin, Cem.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1998
Subjects: subject: Engineering, Civil.

description: Bridges like other important lifeline structures must remain in service when they are subjected to strong earthquakes. Many existing bridges, especially those built before the 1970s, are vulnerable to seismic damage since a number of deficiencies with regard to low design force levels, inadequate column confinement and lack of shear capacity were discovered during recent earthquakes. Bridge columns are expected to withstand seismically induced inertia forces without a significant loss of strength. This can be achieved in old columns through external retrofitting. Many reinforced concrete bridge columns in California were already retrofitted with steel jackets to enhance flexural ductility and shear resistance. Although this retrofitting technique is highly effective, it is also time consuming and costly, especially in view of the fact that high number of columns are yet to be retrofitted. Therefore, a new retrofitting technique has been developed through experimental research that involves external prestressing of bridge columns for improved deformability and shear strength. The supporting experimental work involved testing of 1485 mm high two 550 mm square and five 610 mm diameter circular cantilever columns. The columns were retrofitted with post-tensioned external hoops and high-strength steel straps at different spacing and stress levels. The results indicated that transverse prestressing of shear-dominant columns improved ductility and changed the mode of behavior from a brittle shear response to a ductile flexural behavior. The research project also included analysis of columns to establish lateral drift demands and capacities for bridge columns in Canada. A comprehensive survey of existing bridges in Canada was conducted to identify and classify common types of existing bridges in terms of their numbers, types, age, and structural and geometric properties. This information proved to be helpful in establishing column drift capacities and demands. A computer software DRAIN-RC, developed for non-linear dynamic analysis of reinforced concrete structures, was used to determine the drift demands of columns under various ground motions. Drift capacities were computed by a computer program COLA, developed by the author. The program COLA uses proper material models such as confinement of core concrete, extension of longitudinal reinforcement in tension, and buckling of re-bars in compression. The decision for retrofitting depended on the capacity of a column when demand exceeded its capacity.
Assessing the carbon capture potential of silicate materials with different soils and organic supplements
Creators: name: Freije, Toribio
Publisher: name: Southern Cross University
Year: 2023
Subjects: Enhanced weathering
Silicate materials
Soil types
Dissolution rates
Carbon dioxide sequestration potential

description: Enhanced weathering is a promising technology for carbon sequestration. The process involves the addition, and subsequent dissolution, of certain silicate materials which increases total alkalinity (TA) in soils. To date, there is a considerable research gap regarding the interaction between different soil types, various silicate materials, and organic matter. Furthermore, only a handful of silicate materials have been assessed for their weathering capacity, and different measurement methodologies have been utilised. In general, most studies use a measured alkalinity increase to calculate subsequent CO2 sequestration and ignore dissolved inorganic carbon (DIC) dynamics, which influences uptake potential.
description: To close these knowledge gaps, this study compared the dissolution rates of 6 different silicate materials, including by-products of different industries such as basalt fines, fly ash and slag, in pure water. Then, the dissolution of three of these minerals was assessed in four different Australian soil types by measuring the changes in TA, DIC, total inorganic carbon, and total organic carbon. In a second experiment, the interaction of organic matter in soils, both raw and carbonised, with alkalinity generating basalt was assessed in soil columns.
description: One of the primary outcomes from the dissolution experiment was that basalt and iron slag were the two silicate materials with the highest dissolution rate per mass of feedstock. The incubation experiments in soils showed that the soil type strongly influences the enhanced weathering capacity of silicate materials. In particular, the soil pH and cation exchange capacity were important factors in regulating the dissolution of silicates in soil. The column experiment with silicate materials (basalt) and organic wastes (ryegrass and tannery waste, or hydrochar) showed that alkaline basalt added with the organics significantly impacted CO2 production during the experiment (12 weeks), and the addition of ryegrass had a major impact on both the CO2 production and dissolved organic carbon pools.
description: Finally, this study lists the most critical parameters to analyse and compare prior to and after applying silicate materials in various types of soils.
Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces
Creators: name: Dopler, Arthur
name: Stibitzky, Selina
name: Hevey, Rachel
name: Mannes, Marco
name: Guariento, Mara
name: Höchsmann, Britta
name: Schrezenmeier, Hubert
name: Ricklin, Daniel
name: Schmidt, Christoph Q.
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Complement system
subject: Factor H related protein 1
subject: FHR-1
subject: Factor H (FH)
subject: FH deregulation
subject: Sialic acid
subject: DDC 570 / Life sciences
subject: DDC 610 / Medicine & health
subject: Complement system proteins
subject: N-acetylneuraminic acid
subject: Komplement

description: To discriminate between self and non-self surfaces and facilitate immune surveillance, the complement system relies on the interplay between surface-directed activators and regulators. The dimeric modulator FHR-1 is hypothesized to competitively remove the complement regulator FH from surfaces that strongly fix opsonic C3b molecules—a process known as “deregulation.” The C-terminal regions of FH and FHR-1 provide the basis of this competition. They contain binding sites for C3b and host surface markers and are identical except for two substitutions: S1191L and V1197A (i.e., FH “SV”; FHR-1 “LA”). Intriguingly, an FHR-1 variant featuring the “SV” combination of FH predisposes to atypical hemolytic uremic syndrome (aHUS). The functional impact of these mutations on complement (de)regulation, and their pathophysiological consequences, have largely remained elusive. We have addressed these questions using recombinantly expressed wildtype, mutated, and truncated versions of FHR-1 and FH. The “SV” to “LA” substitutions did not affect glycosaminoglycan recognition and had only a small effect on C3b binding. In contrast, the two amino acids substantially affected the binding of FH and FHR-1 to α2,3-linked sialic acids as host surfaces markers, with the S-to-L substitution causing an almost complete loss of recognition. Even with sialic acid-binding constructs, notable deregulation was only detected on host and not foreign cells. The aHUS-associated “SV” mutation converts FHR-1 into a sialic acid binder which, supported by its dimeric nature, enables excessive FH deregulation and, thus, complement activation on host surfaces. While we also observed inhibitory activities of FHR-1 on C3 and C5 convertases, the high concentrations required render the physiological impact uncertain. In conclusion, the SV-to-LA substitution in the C-terminal regions of FH and FHR-1 diminishes its sialic acid-binding ability and results in an FHR-1 molecule that only moderately deregulates FH. Such FH deregulation by FHR-1 only occurs on host/host-like surfaces that recruit FH. Conversion of FHR-1 into a sialic acid binder potentiates the deregulatory capacity of FHR-1 and thus explains the pathophysiology of the aHUS-associated FHR-1 “SV” variant.
Development of Inhibitors of Human PCSK9 as Potential Regulators of LDL-Receptor and Cholesterol
Creators: name: Alghamdi, Rasha Hassen
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Proprotein Convertase Subtilisin/Kexin 9
PCSK9
Low Density Lipoprotein Receptor
LDL-R
Low Density Lipoprotein Cholesterol
LDL-C
Cardiovascular Disease
CVD
Autosomal Dominant Hypercholesterolemia
ADH
Catalytic Domain
Inhibitors
Peptides Design
LDL-R Degradation
Epidermal Growth Factor like repeat A
EGF-A
Familial Hypercholesterolemia
FH
Gain-of-Function Mutations

description: Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) is the ninth member of the Ca+2-dependent mammalian proprotein convertase super family of serine endoproteases that is structurally related to the bacterial subtilisin and yeast kexin enzymes. It plays a critical role in the regulation of lipid metabolism and cholesterol homeostasis by binding to and degrading low-density lipoprotein-receptor (LDL-R) which is responsible for the clearance of circulatory LDL-cholesterol from the blood. Owing to this functional property, there is plenty of research interest in the development of functional inhibitors of PCSK9 which may find important biochemical applications as therapeutic agents for lowering plasma LDL-cholesterol. The catalytic domain of PCSK9 binds to the EGF-A domain of LDL-R on the cell surface to form a stable complex and re-routes the receptor from its normal endosomal recycling pathway to the lysosomal compartments leading to its degradation. Owing to these findings, we propose that selected peptides from PCSK9 catalytic domain, particularly its disulphide (S-S) bridged loop1 323-358 and loop2 365-385, are likely to exhibit strong affinity towards the EGF-A domain of LDL-R. Several regular peptides along with corresponding all- dextro and retro-inverse peptides as well as the gain-of-function mutant variants were designed and tested for their regulatory effects towards LDL-R expression and PCSK9-binding in human hepatic HepG2 and mouse hepatic Hepa1c1c7 cells. Our data indicated that disulfide bridged loop1-hPCSK9323-358 and its H357 mutant as well as two short loop2-hPCSK9372-380 and its Y374 mutant peptides modestly promote the LDL-R protein levels. Our study concludes that specific peptides from the PCSK9 catalytic domain can regulate LDL-R and may be useful for development of novel class of therapeutic agents for cholesterol regulation.
Packet voice over non-QoS networks.
Creators: name: Xu, Tie.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1999
Subjects: subject: Engineering, Electronics and Electrical.

description: Past communication networks were characterized by separate networks for data and voice. The integration of data and voice in a unique network rapidly gained more and more interest. This integration can provide bandwidth efficiency and new integrated services. The traditional packet switched network cannot be directly applied to voice communication, because it doesn't provide quality of service (QoS). One solution is to modify the network structure to provide new real-time services. Application adaptation provides an alternative solution, with which we can build real-time applications upon currently available network services. The adaptations include bandwidth control, lost packet recovery, delay jitter control, and operating scheduling compensation. The key problem is delay jitter compensation. In this thesis, the application adaptation solution is discussed and algorithms are surveyed. A simulation tool is developed to study the jitter management problem. By managing the tradeoff between display latency and gap frequency, and by dynamically adjusting the display latency according to network conditions. we can provide acceptable voice transmission as long as the average bandwidth is sufficient.
title: Effect of Fibre Material and Fibre Roughness on the Pullout Behaviour of Metallic Micro Fibres Embedded in UHPC
Creators: name: Wiemer, Niels
name: Wetzel, Alexander
name: Schleiting, Maximilian
name: Krooß, Philipp
name: Vollmer, Malte
name: Niendorf, Thomas
name: Böhm, Stefan
name: Middendorf, Bernhard
Publisher: name: Universität Kassel
Year: 2020
Subjects: subject: high-performance concrete
subject: fibre reinforcement
subject: shape memory alloys
subject: pullout strength
subject: fibre/matrix bond
subject: 500
subject: Ultrahochfester Beton
subject: Mikrofaser
subject: Memory-Legierung
subject: Mechanische Eigenschaft

description: Gefördert durch den Publikationsfonds der Universität Kassel
Le corps de l'hospitalité : Éthique et matérialité, d'Emmanuel Levinas à Jacques Derrida
Creators: name: Morar, Mihaela Cristina
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2014
Subjects: Corps et sensibilité
Emmanuel Levinas
Jacques Derrida
Éthique et politique de l'hospitalité

description: L’objectif poursuivi dans cette thèse est de rendre compte de l’émergence, dans la réflexion philosophique de l’après-guerre, d’une préoccupation pour les questions de l’affect et de la corporéité. Nous abordons cette orientation affective et sensible de la pensée avec les œuvres des philosophes français Emmanuel Levinas et Jacques Derrida, qui l’ont infléchie dans le sens d’une prise en compte de la fragilité et de la précarité de l’existence. Cela donne lieu à deux pensées incarnées. Le corps est chez Levinas à la fois ce qui pose dans l’être et permet de se vouer à autrui. Chez Derrida, c’est l’écriture qui fait sortir hors de soi, venant espacer et différer l’identité. Le défi sera de montrer que l’écriture relève, elle aussi, du registre de la corporéité. Les deux pensées reconnaissent ainsi au corps une place importante dans l’élaboration d’une nouvelle conceptualité qui se produit aux interstices de la vie et de l’œuvre. On a affaire dans les deux cas à des écritures vivantes, poétiques, métaphoriques, qui affectent le lecteur et ouvrent ainsi des avenues nouvelles pour penser les questions éthiques et politiques. Les deux philosophes engagent de la sorte la métaphysique et l’ontologie dans un mouvement, allant du même vers l’autre, et faisant du sentir et du pâtir le lieu même d’une nouvelle expérience philosophique. Nous en rendons compte en termes d’une orientation matérialiste de la pensée ainsi que d’une notion de subjectivité conçue, à travers le prisme de l’hospitalité, comme ouverture à l’autre.
Influence of menopause on inflammatory cytokines during murine and human bone fracture healing
Creators: name: Fischer, Verena
name: Kalbitz, Miriam
name: Müller-Graf, Fabian
name: Gebhard, Florian
name: Ignatius, Anita
name: Liedert, Astrid
name: Haffner-Luntzer, Melanie
Publisher: name: Universität Ulm
Year: 2018
Subjects: subject: Osteoblastogenesis
subject: DDC 610 / Medicine & health
subject: Midkine
subject: Fracture healing
subject: Bone regeneration
subject: Inflammation
subject: Menopause
subject: Knochenbruch
subject: Osteoblast
subject: Entzündung

description: Postmenopausal females display a chronic inflammatory phenotype with higher levels of circulating pro-inflammatory cytokines. Furthermore, the inflammatory response to injury may be altered under estrogen-deficiency, because it was shown previously that estrogen-deficient mice displayed increased levels of the inflammatory cytokines Midkine (Mdk) and Interleukin-6 (IL-6) in the early fracture hematoma. Because a balanced immune response to fracture is required for successful bone regeneration, this might contribute to the delayed fracture healing frequently observed in osteoporotic, postmenopausal fracture patients. In this study, we aimed to investigate whether further cytokines in addition to Mdk and IL-6 might be affected by estrogen-deficiency after fracture in mice and whether these cytokines are also relevant during human fracture healing. Additionally, we aimed to investigate whether serum from male vs. female fracture patients affects osteogenic differentiation of human mesenchymal stem cells (MSCs). To address these questions, female mice were either sham-operated or ovariectomized (OVX) and subjected to standardized femur osteotomy. A broad panel of pro- and anti-inflammatory cytokines was determined systemically and locally in the fracture hematoma. In a translational approach, serum was collected from healthy controls and patients with an isolated fracture. Mdk and IL-6 serum levels were determined at day 0, day 14 and day 42 after fracture. Subgroup analysis was performed to investigate differences between male and female fracture patients after menopause. In an in vitro approach, human MSCs were cultured with the collected patient serum and osteogenic differentiation was assessed by qPCR and alkaline-phosphatase staining. Our results suggest an important role for the pro-inflammatory cytokines Mdk and IL-6 in the response to fracture in estrogen-deficient mice among all of the measured inflammatory mediators. Notably, both cytokines were also significantly increased in the serum of patients after fracture. However, only Mdk serum levels differed significantly between male and female fracture patients after menopause. MSCs cultivated with serum from female fracture patients displayed significantly reduced osteogenic differentiation, which was attenuated by Mdk-antibody treatment. In conclusion, our study demonstrated increased Mdk levels after fracture in OVX mice and female fracture patients after menopause. Because Mdk is a negative regulator of bone formation, this might contribute to impaired osteoporotic fracture healing.
Supplementary document for Analysis and optimization of light outcoupling in OLEDs with external hierarchical textures - 5198201.pdf
Creators: name: Kovacic, Milan
name: Samigullina, Dinara
name: Bouchard, Felix
name: Krc, Janez
name: Lipovsek, Benjamin
name: Soldera, Marcos
name: Lasagni, Andrés
name: Reineke, Sebastian
name: Topic, Marko
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Uncategorized

description: Supplementary information
Resilience of a sub-tropical riparian rainforest in Australia to major flood
Creators: name: Martiniello, Leandra
Publisher: name: Southern Cross University
Year: 2023
Subjects: Rainforest ecology
Forest ecology
Disturbance ecology
Floods
Forest soils
Riparian soils

description: Riparian rainforests are part of a complex set of interactions between hydrology, geomorphology, and vegetation ecology. Flooding in riparian forests is an essential disturbance process and riparian species have evolved functional traits to persist with riparian stressors. Traits may include responding to disturbance by vegetative regeneration or by life history strategies (seedling recruitment). Riparian soils are vulnerable to undergoing periodic erosion and deposition, potentially causing alterations in essential plant–soil feedbacks. Climate change models predict increased frequency and intensity of flooding and the implications of this on these high conservation value ecosystems is unknown. This research aimed to answer the following questions: (i) what is the resilience of old growth riparian rainforests after severe flooding? (ii) what is the resilience of riparian soils after severe flooding? Abundance and structurally based flora surveys and soil physical and chemical assessment were undertaken at the riparian rainforest at Rocky Creek, The Channon Gorge in late 2021. After catastrophic flooding in early 2022, sites were remeasured at regular intervals after flood, and the identity and abundance of resprouting individuals and seedling recruits were additionally recorded. Species richness and native plant density significantly increased after flooding; smaller plants (<10 m height and <10 cm DBH) were the most affected. Over half the rainforest taxa present demonstrated the capacity to persist after flood by resprouting or recruiting seed; new taxa were resprouting and new native taxa were being recruited to the site up to 1-year post-flood. There was a significant change in floristic composition before and immediately after flood (P= 0.026), but at one year after the flood the community was becoming more floristically similar to its pre-flood composition. Diverse soil types at varying stages of pedological development were recorded. Surface soil nutrient levels changed significantly after flood due to erosion and twelve months post-flood soil nutrients had not fully recovered. The riparian rainforest community exhibited high resilience to high intensity flooding. Soil properties, physical and chemical had low resilience to high intensity flooding. If high-impact events co-occur immediately after flood when system resilience is lowered there is risk for the initiation of positive feedbacks involving soil erosion-nutrient loss and impeded vegetation recovery to cause further degradation. The temporal limitations of this research do not allow for measuring the success rates of post-flood germinated seedlings. Future research should investigate this further and the influence of erosion and soil nutrient status on this success.
NTM ( Network Traffic Management) needs assessment and system requirements
Creators: name: Franco, Daniel
name: Juliat, Morgane
name: Bandyopadhyay, Sounak
name: Landaluce, Hugo
name: Ghosh, Arka
name: Masegosa, Antonio D.
name: SERRANO, LEIRE
Publisher: name: Zenodo
Year: 2024
Subjects: Network traffic management
stakeholder engagement
system requirements
technical and operational requirements

description: This document aims at identifying the system requirements for the TANGENT functionalities for each case study, based on a detailed definition and description of each case study and a comprehensive consultation and engagement process with local stakeholders. In this way, it reports on the evaluation of stakeholders’ needs and the analysis of the requirements of the local transport network for the architecture definition, design, and operation of TANGENT services for advanced traffic and network management.First, this deliverable defines the process and methodology used to develop the system requirements. Chapter 3 provides a detailed description of each of the functionalities that would be tested in TANGENT, including a description of the needs and requirements of the case studies testing this functionality. Chapter 4 provides a detailed and comprehensive – yet not final – description of each of the use cases, including a description of the local context, the characterization of the local transport network, the stakeholder mapping, the traffic management strategies, the transport modelling, an overview of an impact canvas, the definition of scopes and scenarios and a description of visualization and interaction of data. Chapter 5 provides an overview of the system requirements while the final list of system requirements can be found in Annexe II at the end of this report.As for the system requirements of the TANGENT platform, a total of 154 requirements were successfully collected, which are fundamental to guide the developments to be carried out in the coming months in work packages 2, 3, 4, 5 and 6.
La laicità dello Stato e le nuove interrelazioni tra etica e diritto
Creators: name: Valentini, Valentina
Publisher: name: Stato, Chiese e pluralismo confessionale
Year: 2011

description: SOMMARIO: 1. Il principio di laicità dello Stato. Cenni storico-comparatistici - 2. Segue: dallo Stato liberale allo Stato laico sociale - 3. La laicità dello Stato e l’indipendenza delle Chiese - 4. Le istituzioni democratiche e la pluralità delle scelte etiche - 5. Il ruolo della riflessione etica nel diritto - 6. Laicità e biodiritto - 7.
Le questioni bioetiche ed il principio di laicità.
description: Stato, Chiese e pluralismo confessionale, 2008: 9 luglio
Hedging your bets : the importance of flowering time and agronomic practise in the search for the ideal Australian hemp seed cultivar
Creators: name: Panerio, Rafael Julian G.
Publisher: name: Southern Cross University
Year: 2020
Subjects: Hemp
Cannabis
Flowering time
Seed production

description: This work investigated the effects of photoperiod and hedging on the different agronomic traits of Chinese hemp cultivars in Australia. Photoperiod was identified as the key limiting factor affecting biomass and seed yield during short-day planting regimes. Results demonstrated that hedging increased branching, but did not affect seed yield or plant biomass; while differences observed in the fatty acid profiles were genotype-specific. This project highlighted the importance of selecting suitable genotypes and sowing times for successful hemp seed production. Additionally, a putative flowering time orthologue was identified as a step in identifying genetic diversity for future breeding efforts.
Resource allocation in selected Australian universities
Creators: name: Eedle, Elizabeth
Publisher: name: Swinburne
Year: 2024

description: Australian universities are multi-million dollar operations employing tens of thousands of people. They attract revenue from a variety of government and non-government sources, and yet, as non-profit organisations they are judged by governments, peers and their communities on their performance in teaching and research rather than on a financial bottom line. In order to achieve these results, university managers must make decisions on how to allocate available funding throughout the university. Faced with competing demands on scarce funds, how do university managers make these choices? One option is to use a resource allocation model to 'crunch the numbers'. Resource allocation models can incorporate a number of elements -- student and staff numbers, weightings and performance data, for example -- to allocate available funds. These allocation models are used in different ways in different universities, but serve the same basic purpose of assisting decision-making on how much to allocate to different sections of the organisation. Such models operate within a process and context that includes the strategic aims of the University, the organisation structure, its committees and culture. This thesis contains case studies of resource allocation models and processes used in three Australian universities. It examines the methods used for resource allocation at the first and second levels within each university; that is, from the Vice-Chancellor to Dean (or equivalent), and from Dean to Head of School (or equivalent). Observations and conclusions are drawn on the models used, the processes surrounding the models, and the continuity between the two layers of allocations. The research finds all the case-study universities operate models at multiple levels in their organisations, and that there is a concerning lack of consistency and flow-through at these different levels. The messages that the university leadership intends to send through the allocations may be lost to managers one-process removed from them. The research also concludes that transparency is the most important element of the resource allocation process. University staff dealing with allocation processes will accept the results, even if they are not ideal, if they can understand how and why decisions were made. As a professional doctorate thesis, the aim is to provide a practical aid to people with responsibility for resource allocation in universities.