cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Nonlinearity in a dynamo
Creators: name: Hejda, P.
name: Reshetnyak, M.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: Using a rotating flat layer heated from below as an example, we consider effects which lead to stabilizing an exponentially growing magnetic field in magnetostrophic convection in transition from the kinematic dynamo to the full non-linear dynamo. We present estimates of the energy redistribution over the spectrum and helicity quenching by the magnetic field. We also study the alignment of the velocity and magnetic fields. These regimes are similar to those in planetary dynamo simulations.
description: Accepted to Geophys. Astrophys. Fluid Dynam
Inhibition of IKKβ by celastrol and its analogues – an in silico and in vitro approach
Creators: name: Karpagam Veerappan
name: Sathishkumar Natarajan
name: Purushoth Ethiraj
name: Vetrivel, Umashankar
name: Samuel, Shila
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Context: Alzheimer’s disease (AD) is the most common form of dementia affecting the aged population and neuroinflammation is one of the most observed AD pathologies. NF-κB is the central regulator of inflammation and inhibitor κB kinase (IKK) is the converging point in NF-κB activation. Celastrol is a natural triterpene used as a treatment for inflammatory conditions. Objective: This study determines the neuroprotective and inhibitory effect of celastrol on amyloid beta1-42 (Aβ1-42) induced cytotoxicity and IKKβ activity, respectively. Materials and methods: Retinoic acid differentiated IMR-32 cells were treated with celastrol (1 μM) before treatment with Aβ1-42 (IC30 10 μM) for 24 h. The cytotoxicity and IKK phosphorylation were measured by MTT and western blotting analysis, respectively. We screened 36 celastrol analogues for the IKKβ inhibition by molecular docking and evaluated their drug like properties to delineate the neuroprotective effects. Results: Celastrol (1 μM) inhibited Aβ1-42 (10 μM) induced IκBα phosphorylation and protected IMR-32 cells from cell death. Celastrol and 25 analogues showed strong binding affinity with IKKβ as evidenced by strong hydrogen-bonding interactions with critical active site residues. All the 25 analogues displayed strong anti-inflammatory properties but only 11 analogues showed drug-likeness. Collectively, molecule 15 has highest binding affinity, CNS activity and more drug likeness than parent compound celastrol. Discussion and conclusion: The decreased expression of pIκBα in celastrol pretreated cells affirms the functional representation of inhibited IKKβ activity in these cells. The neuroprotective potentials of celastrol and its analogues may be related to IKK inhibition.
Freeform Templates: Combining Freeform Curation with Structured Templates
Creators: name: MacNeil, Stephen
name: Huang, Ziheng
name: Chen, Kenneth
name: Ding, Zijian
name: Yu, Alex
name: Nakai, Kendall
name: Dow, Steven P.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences
subject: H.5.0

description: Online whiteboards are becoming a popular way to facilitate collaborative design work, providing a free-form environment to curate ideas. However, as templates are increasingly being used to scaffold contributions from non-experts designers, it is crucial to understand their impact on the creative process. In this paper, we present the results from a study with 114 students in a large introductory design course. Our results confirm prior findings that templates benefit students by providing a starting point, a shared process, and the ability to access their own work from previous steps. While prior research has criticized templates for being too rigid, we discovered that using templates within a free-form environment resulted in visual patterns of free-form curation where concepts were spatially organized, clustered, color-coded, and connected using arrows and lines. We introduce the concept of "Free-form Templates" to illustrate how templates and free-form curation can be synergistic.
Ent-trachylobane-3β-hydroperoxide, a new diterpene from the root bark of Chrozophora oblongifolia (Fam.; Euphorbiaceae)
Creators: name: Kamel, Mohamed R.
name: Nafady, Alaa M.
name: Hassanein, Ahmed M. M.
name: Hassan, Ahmed R.
name: Shimizu, Kuniyoshi
name: Ibrahim, Reham R.
name: Haggag, Eman G.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Plant Biology

description: New ent-trachylobane-3β-hydroperoxide (5) together with four known compounds, ricinine (1), trimethoxy ellagic acid (2), dimethoxy ellagic acid (3) and aleurotolic acid (4) were isolated from the methylene chloride fraction of the root bark of Chrozophora oblongifolia. The structures of these secondary metabolites were elucidated by using different spectroscopic techniques, 1H NMR, 13C NMR, HSQC, HMBC, 1H-1H COSY, NOESY, HR-ESI-MS, EI-MS and comparison with published data. Ent-trachylobane-3β-hydroperoxide showed moderate cytotoxic activity by MTT assay method against human breast cancer cells (MCF-7) and human hepatocyte-derived carcinoma cells (Huh-7) with IC50 values of 24.53 and 34.13 µM, in comparison with IC50 values of 23.47 µM and 15.82 µM for 5-fluorouracil respectively.
title: Quartierspiegel Albisrieden 2024
Creators: name: (:Unkn) Unknown
Publisher: name: Zentralbibliothek Zürich
Year: 2024
Subjects: subject: 314 Allgemeine Statistiken zu Europa
subject: 710 Städtebau, Raumplanung, Landschaftsgestaltung
subject: 949 Geschichte anderer Teile Europas
subject: Albisrieden
subject: Zürich / Kreis 9
subject: Quartier
subject: Amtliche Statistik
subject: Bevölkerungsstatistik

description: Das Quartier Albisrieden hat im Laufe des letzten Jahrhunderts eine gewaltige Entwicklung vom Bauerndorf zum Technologiestandort durchgemacht. Gleichwohl hat es seinen ländlichen Charakter nie ganz verloren, wovon der beeindruckende historische Dorfkern zeugt.
The Evolution of PSR J0737-3039B and a Model for Relativistic Spin Precession
Creators: name: Perera, Benetge
name: McLaughlin, Maura
name: Kramer, Michael
name: Stairs, Ingrid
name: Ferdman, Robert
name: Freire, Paulo
name: Possenti, Andrea
name: Breton, Rene
name: Manchester, Richard N.
name: Burgay, Marta
name: Lyne, Andrew
name: Camilo, Fernando
Publisher: name: arXiv
Year: 2010
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present the evolution of the radio emission from the 2.8-s pulsar of the double pulsar system PSR J0737-3039A/B. We provide an update on the Burgay et al. (2005) analysis by describing the changes in the pulse profile and flux density over five years of observations, culminating in the B pulsar's radio disappearance in 2008 March. Over this time, the flux density decreases by 0.177 mJy/yr at the brightest orbital phases and the pulse profile evolves from a single to a double peak, with a separation rate of 2.6 deg/yr. The pulse profile changes are most likely caused by relativistic spin precession, but can not be easily explained with a circular hollow-cone beam as in the model of Clifton & Weisberg (2008). Relativistic spin precession, coupled with an elliptical beam, can model the pulse profile evolution well. This particular beam shape predicts geometrical parameters for the two bright orbital phases which are consistent and similar to those derived by Breton et al. (2008). However, the observed decrease in flux over time and B's eventual disappearance cannot be easily explained by the model and may be due to the changing influence of A on B.
description: 20 pages, 18 figures, Accepted by ApJ on 2 August 2010
Dynamic Score-Driven Independent Component Analysis
Creators: name: Hafner, Christian M.
name: Herwartz, Helmut
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: A model for dynamic independent component analysis is introduced where the dynamics are driven by the score of the pseudo likelihood with respect to the rotation angle of model innovations. While conditional second moments are invariant with respect to rotations, higher conditional moments are not, which may have important implications for applications. The pseudo maximum likelihood estimator of the model is shown to be consistent and asymptotically normally distributed. A simulation study reports good finite sample properties of the estimator, including the case of a misspecification of the innovation density. In an application to a bivariate exchange rate series of the Euro and the British Pound against the U.S. Dollar, it is shown that the model-implied conditional portfolio kurtosis largely aligns with narratives on financial stress as a result of the global financial crisis in 2008, the European sovereign debt crisis (2010–2013) and early rumors signalling the United Kingdom to leave the European Union (2017). These insights are consistent with a recently proposed model that associates portfolio kurtosis with a geopolitical risk factor.
Antioxidant, anti-inflammatory and anti-septic potential of phenolic acids and flavonoid fractions isolated from Lolium multiflorum
Creators: name: Ki-Choon Choi
name: Son, Young-Ok
name: Hwang, Jung-Min
name: Beom-Tae Kim
name: Minseon Chae
name: Jeong-Chae Lee
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Physiology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: Hematology

description: Context: Interest has recently renewed in using Lolium multiflorum Lam. (Poaceae) (called Italian ryegrass; IRG) silage as an antioxidant and anti-inflammatory diet. Objective: This study investigated the antioxidant, anti-inflammatory and anti-septic potential of IRG silage and identified the primary components in IRG active fractions. Materials and methods: Total 16 fractions were separated from the chloroform-soluble extract of IRG aerial part using Sephadex LH-20 column before HPLC analysis. Antioxidant and anti-inflammatory activities of the fractions at doses of 0–100 μg/mL were investigated using various cell-free and cell-mediated assay systems. To explore anti-septic effect of IRG fractions, female ICR and BALB/c mice orally received 40 mg/kg of phenolic acid and flavonoid-rich active fractions F7 and F8 every other day for 10 days, respectively, followed by LPS challenge. Results: The active fractions showed greater antioxidant and anti-inflammatory potential compared with other fractions. IC50 values of F7 and F8 to reduce LPS-stimulated NO and TNF-α production were around 15 and 30 μg/mL, respectively. Comparison of retention times with authentic compounds through HPLC analysis revealed the presence of caffeic acid, ferulic acid, myricetin and kaempferol in the fractions as primary components. These fractions inhibited LPS-stimulated MAPK and NF-κB activation. Supplementation with F7 or F8 improved the survival rates of mice to 70 and 60%, respectively, in LPS-injected mice and reduced near completely serum TNF-α and IL-6 levels. Discussion and conclusion: This study highlights antioxidant, anti-inflammatory and anti-septic activities of IRG active fractions, eventually suggesting their usefulness in preventing oxidative damage and inflammatory disorders.
title: Quartierspiegel Altstetten 2024
Creators: name: (:Unkn) Unknown
Publisher: name: Zentralbibliothek Zürich
Year: 2024
Subjects: subject: 314 Allgemeine Statistiken zu Europa
subject: 710 Städtebau, Raumplanung, Landschaftsgestaltung
subject: 949 Geschichte anderer Teile Europas
subject: Zürich-Altstetten
subject: Zürich / Kreis 9
subject: Quartier
subject: Amtliche Statistik
subject: Bevölkerungsstatistik

description: Ein Quartier im Wandel: Während bisher vor allem Bauten aus der Zeit nach 1940 Altstettens Bild prägten, schiessen inzwischen neue Grossbauten wie der WestLink Tower aus dem Boden. Und mit weiteren geplanten Projekten in den Bereichen Transportinfrastruktur, Wohnen und Industrie bleibt sichergestellt, dass der Boom auch anhält.
The Wall of Fundamental Constants
Creators: name: Olive, Keith A.
name: Peloso, Marco
name: Uzan, Jean-Philippe
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We consider the signatures of a domain wall produced in the spontaneous symmetry breaking involving a dilaton-like scalar field coupled to electromagnetism. Domains on either side of the wall exhibit slight differences in their respective values of the fine-structure constant, alpha. If such a wall is present within our Hubble volume, absorption spectra at large redshifts may or may not provide a variation in alpha relative to the terrestrial value, depending on our relative position with respect to the wall. This wall could resolve the ``contradiction'' between claims of a variation of alpha based on Keck/Hires data and of the constancy of alpha based on VLT data. We derive the properties of the wall and the parameters of the underlying microscopic model required to reproduce the possible spatial variation of alpha. We discuss the constraints on the existence of the low-energy domain wall and describe its observational implications concerning the variation of the fundamental constants.
description: 7 pages, 3 figures
Size characterization of particles using capillary electrophoresis
Creators: name: Khodabandehloo, Akram
Publisher: name: University of British Columbia
Year: 2019

description: Taylor dispersion analysis (TDA) can be used for characterizing size of particles over a wide range. This method is performed on a capillary column and its simplicity and reproducibility offer many advantages over other more commonly used techniques for sizing. In the first part of the thesis, different sizing techniques are reviewed and their advantages and disadvantages are discussed. In the second part of this thesis, numerical modeling is used to optimize the operating conditions for performing TDA. In addition, the validity of TDA conditions is verified and the optimum conditions for performing TDA are discussed. Also, the effect of electric field on the validity of TDA and its application for a mixture of molecules with different sizes is studied. It is concluded that care must be taken to choose parameters in a way that lead to optimal TDA results. For the mixtures, using electric field is advantageous, because it not only leads to separation of molecules but also gives information on the charge of the molecules. In addition to numerical modeling, the equations for TDA to be used in the presence of electrophoretic mobility are modified and compared to the diffusion coefficients obtained using classical TDA. In this part of thesis, in addition to pressure, voltage is also applied to separate the components of mixtures and characterize the size of individual species. The results indicate that using the modified equations make the resulting values more consistent with the ones obtained from classical TDA. Our method can be used for mixtures, and in this thesis, a preliminary attempt has been made to characterize the size and charge of a mixture of proteins and peptides and amino acids. The final part of this thesis discusses the dispersion of proteins and small peptides during electrokinetic migration. Like conventional Taylor dispersion, peak broadening is more prronounced for particles with smaller diffusion coefficients. The theoretical description of band broadening caused by electroosmotic flow dispersion (EOFD) and the experimental verification of this phenomenon are presented.
Endophytic fungi associated with Monarda citriodora, an aromatic and medicinal plant and their biocontrol potential
Creators: name: Katoch, Meenu
name: Shipra Pull
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Plant Biology

description: Context: The Food and Agriculture Organization has estimated that every year considerable losses of the food crops occur due to plant diseases. Although fungicides are extensively used for management of plant diseases, they are expensive and hazardous to the environment and human health. Alternatively, biological control is the safe way to overcome the effects of plant diseases and to sustain agriculture. Since Monarda citriodora Cerv. ex Lag. (Lamiaceae/Labiatae) is known for its antifungal properties, it was chosen for the study. Objective: The isolation of endophytic fungi from M. citriodora and assessing their biocontrol potential. Material and methods: The isolated endophytes were characterized using ITS-5.8 S rDNA sequencing. Their biocontrol potential was assessed using different antagonistic assays against major plant pathogens. Results: Twenty-eight endophytes representing 11 genera were isolated, of which, around 82% endophytes showed biocontrol potential against plant pathogens. MC-2 L (Fusarium oxysporum), MC-14 F (F. oxysporum), MC-22 F (F. oxysporum) and MC-25 F (F. redolens) displayed significant antagonistic activity against all the tested pathogens. Interestingly, MC-10 L (Muscodor yucatanensis) completely inhibited the growth of Sclerotinia sp., Colletotrichum capsici, Aspergillus flavus and A. fumigatus in dual culture assay, whereas MC-8 L (A. oryzae) and MC-9 L (Penicillium commune) completely inhibited the growth of the Sclerotinia sp. in fumigation assay. Conclusions: Endophytes MC-2 L, MC-14 F, MC-22 F and MC-25 F could effectively be used to control broad range of phytopathogens, while MC-10 L, MC-8 L and MC-9 L could be used to control specific pathogens. Secondly, endophytes showing varying degrees of antagonism in different assays represented the chemo-diversity not only as promising biocontrol agents but also as a resource of defensive and bioactive metabolites.
The effect of twisted magnetic field on the resonant absorption of MHD waves in coronal loops
Creators: name: Karami, K.
name: Bahari, K.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The standing quasi modes in a cylindrical incompressible flux tube with magnetic twist that undergoes a radial density structuring is considered in ideal magnetohydrodynamics (MHD). The radial structuring is assumed to be a linearly varying density profile. Using the relevant connection formulae, the dispersion relation for the MHD waves is derived and solved numerically to obtain both the frequencies and damping rates of the fundamental and first-overtone modes of both the kink (m=1) and fluting (m=2,3) waves. It was found that a magnetic twist will increase the frequencies, damping rates and the ratio of the oscillation frequency to the damping rate of these modes. The period ratio P_1/P_2 of the fundamental and its first-overtone surface waves for kink (m=1) and fluting (m=2,3) modes is lower than 2 (the value for an untwisted loop) in the presence of twisted magnetic field. For the kink modes, particularly, the magnetic twists B_ϕ/B_z=0.0065 and 0.0255 can achieve deviations from 2 of the same order of magnitude as in the observations. Furthermore, for the fundamental kink body waves, the frequency bandwidth increases with increasing the magnetic twist.
description: 18 pages, 9 figures
Novel ferulic acid and benzophenone derivatives from the flower buds of Syzygium aromaticum
Creators: name: Kiran, Zareena
name: Begum, Sabira
name: Sara, Sara
name: Bano, Zarina
name: Siddiqui, Bina S.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Phytochemical investigation of clove resulted in the isolation of two new natural compounds, a ferulic acid derivative, sabrinic acid (1) and a benzophenone derivative (2) together with two known compounds kaempferol-3,5-dimethyl ether (3) and 4-methyl benzoic acid (4). Compounds 3 and 4 were isolated for the first time from the genus Syzygium. The structures of compounds were elucidated through modern spectroscopic techniques including 1D and 2D NMR spectroscopy.
Remaining Resources of the Herrin Coal
Creators: name: Weisenfluh, Gerald A.
Publisher: name: Kentucky Geological Survey, University of Kentucky
Year: 2011

description: Abstract:
The Herrin coal bed (W. Ky. No. 11) is one of the most important coal resources in the Illinois Basin. To 2009, the Herrin coal had an estimated 10 million tons of production in Kentucky, and remained the second largest producer in the Western Kentucky Coal Field. The Herrin is known for its regionally extensive "blue band" rock parting, and, in Kentucky, its close association with the overlying Providence Limestone Member and Paradise coal (W. Ky. No. 11) (see, for example, Greb and others, 1992). To fact, the Herrin and Paradise coal beds were so closely spaced in some areas along the southern margin of the basin that they were mined together. Like most coals in western Kentucky, the Herrin is a medium-sulfur product. Because of relatively lower mining costs compared to Appalachian coals, the Herrin coal is increasingly in demand for electric power plants with sulfur-reduction capability. Scrubbed power plants can use higher-sulfur coals for fuel because the scrubbers remove almost all of the sulfur dioxide produced by combustion of sulfur compounds in the coal from the emission stream. This recent demand has resulted in a significant increase in western Kentucky coal production since 2003, all of which is supplied by mining of the Herrin and Springfield coal beds.
Copyright: © 2011, University of Kentucky, Kentucky Geological Survey
The application of the essential-use and functional substitution concepts to phase-out harmful chemicals from cosmetic products - Example of persistent and mobile substances
Creators: name: Figuière, Romain
Publisher: name: Zenodo
Year: 2023

description: Presentation given for the Swedish Academic Consortium on Chemical Safety (SWACCS) seminar series on the topic "Our consumables, safety, and essential utility under considerations", on the 6th of December 2023. The presentation presented the work carried out in ZeroPM WP2 on the implementation of the essential-use concept as a tool to phase-out PMT substances from cosmetic products.
Dimeric glycosylated flavan-3-ol and antimicrobial in vitro evaluation of Trichilia catigua extracts
Creators: name: Ritter, Mariane Roberta
name: Oliveira, Marcelo Tempesta de
name: Makimori, Regina Yasuko
name: Sereia, Ana Luiza
name: Simionato, Ane Stefano
name: Chierrito, Danielly
name: Galdino, Andrade Filho
name: de, Oliveira Admilton Gonçalves
name: Silva, Denise Brentan da
name: Novello, Claudio Roberto
name: de, Medeiros Daniela Cristina
name: Prado, Dias Filho Benedito
name: de, Mello João Carlos Palazzo
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: Trichilia catigua is a tree known as “catuaba”, widely distributed in Brazil. Studies carried out with T. catigua barks suggest that plant has antidepressant, antidiabetic, antimicrobial, antioxidant, antiviral, and preventive against brain damage. The aim of this work was to isolate and characterise compounds from the semipurified fraction of T. catigua barks, and to conduct microbiological screening against bacteria and fungi. The crude extract (CE) of “catuaba” was produced by turbo extraction with acetone-water, and later, partitioned to yield ethyl-acetate (EAF) and aqueous (AqF) fractions. From AqF the new catechin-3-O-α-L-rhamnoside-(4α→8)-epicatechin was isolated, identified, and described here for the first time. Regarding antimicrobial activity, the extracts presented impressive results, mainly for Vancomycin Resistant Enterococcus faecium (VREfm) with MIC of 156.5 μg/mL. The results suggest that extract of T. catigua could potentially be used as an adjuvant to treatment and is a promising candidate for the development of new antimicrobial drugs.
Impact on cosmology of the celestial anisotropy of the short gamma-ray bursts
Creators: name: Meszaros, Attila
name: Balazs, Lajos G.
name: Bagoly, Zsolt
name: Veres, Peter
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Recently the anisotropy of the short gamma-ray bursts detected by BATSE was announced (Vavrek et al. 2008). The impact of this discovery on cosmology is discussed. It is shown that the anisotropy found may cause the breakdown of the cosmological principle.
description: 4 pages, 1 figure. Published in Proceedings of the 6th INTEGRAL/BART Workshop, 26-29 March, 2009; Karlovy Vary
Spirodela polyrhiza extract modulates the activation of atopic dermatitis-related ion channels, Orai1 and TRPV3, and inhibits mast cell degranulation
Creators: name: Nam, Joo Hyun
name: Jung, Hyo Won
name: Young-Won Chin
name: Won-Mo Yang
name: Bae, Hyo Sang
name: Kim, Woo Kyung
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Plant Biology

description: Context:Spirodela polyrhiza (L.) Schleid. (Lemnaceae), Spirodelae Herba (SH), has been known to relieve inflammation, urticaria and skin symptoms including pruritus, eczema and rash. Objective: The effects of SH extract on two calcium ion channels, Orai1 and TRPV3, and their potential as novel therapeutics for atopic dermatitis (AD) were investigated. The regulatory role of Orai1 on mast cell degranulation was evaluated. Materials and methods: The dried leaves of SH were extracted by 70% methanol. Effects of SH extract (100 μg/mL) in an HEK293T cell line overexpressing human Orai1 or TRPV3 were assessed. Ion channel modulation in transfected HEK293T cells was measured using a conventional whole-cell patch-clamp technique. IgE-antigen complex-stimulated mast cell degranulation was measured by β-hexosaminidase assay with morphological observation after treatment with 20, 50 and 100 μg/mL SH extract. Results: SH extract (100 μg/mL) significantly inhibited Orai1 activity (63.8 ± 0.97%) in Orai1-STIM1 co-overexpressed HEK293T cells. SH extract significantly increased TRPV3 activity (81.29 ± 0.05% at −100 mV) compared with the positive control 2-APB (100 μM), which induced full activation. SH extract inhibited degranulation in IgE-antigen complex-stimulated RBL-2H3 mast cells by decreasing β-hexosaminidase activity (3.14 ± 0.03, 2.56 ± 0.12 and 2.29 ± 0.08 mU/mg, respectively). Conclusion: Our results suggested that SH extract could treat abnormal skin barrier pathologies in AD through modulation of the activities of the calcium ion channels Orai1 and TRPV3 and inhibition of mast cell degranulation. This is the first report of an herbal effect on the modulation of ion channels associated with skin barrier disruption in AD pathogenesis.
PMDG: Privacy for Multi-Perspective Process Mining through Data Generalization
Creators: name: Hildebrant, Ryan
name: Fahrenkrog-Petersen, Stephan A.
name: Weidlich, Matthias
name: Ren, Shangping
Publisher: name: arXiv
Year: 2023
Subjects: subject: Databases (cs.DB)
subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences

description: Anonymization of event logs facilitates process mining while protecting sensitive information of process stakeholders. Existing techniques, however, focus on the privatization of the control-flow. Other process perspectives, such as roles, resources, and objects are neglected or subject to randomization, which breaks the dependencies between the perspectives. Hence, existing techniques are not suited for advanced process mining tasks, e.g., social network mining or predictive monitoring. To address this gap, we propose PMDG, a framework to ensure privacy for multi-perspective process mining through data generalization. It provides group-based privacy guarantees for an event log, while preserving the characteristic dependencies between the control-flow and further process perspectives. Unlike existin privatization techniques that rely on data suppression or noise insertion, PMDG adopts data generalization: a technique where the activities and attribute values referenced in events are generalized into more abstract ones, to obtain equivalence classes that are sufficiently large from a privacy point of view. We demonstrate empirically that PMDG outperforms state-of-the-art anonymization techniques, when mining handovers and predicting outcomes.
description: 16 Pages
Gold mediated sp3αC-H functionalization of steroidal diglycoside and their anti-cancer evaluation
Creators: name: Kankala, Shravankumar
name: Vadde, Ravinder
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Cancer

description: C(sp3)-H alkylation at α-position of methyl-keto group on D-ring of Steroidal diglycoside (SG) with (i) C=N of Schiff base imines to form amine derivatives and (ii) C=C of acrylate Michael acceptors to form Markovnikov ester products using AuCl3/NHC as pre-catalyst and Ag(I) salts as co-catalyst was described. The original form of SG (1) and its derivatives (3b-f & 5a-d) were screened for in vitro anti-cancer activity specifically on two breast cancer cell lines (i.e. MCF-7, MDA-MB-231) and deduced the structure-activity-relationship with the support of molecular docking studies. Among these compounds 3b, 3f, 5b & 5d have shown more potent anticancer activity than standard drug cisplatin with considerable IC50 values.
The role of adaptive evolution in the success of an agricultural weed, Helianthus annuus
Creators: name: Drummond, Emily Barbara McKenzie
Publisher: name: University of British Columbia
Year: 2019

description: If a weed is defined as a plant that is “growing where it is not wanted”, then agricultural weeds, or plants that invade and persist in cultivated fields, might be the epitome of weeds. Agricultural weeds have arisen repeatedly from wild plant species, often undergoing rapid evolution to escape eradication. While agricultural weeds thus represent an attractive opportunity to study evolutionary processes operating over short timescales, the genetic basis of local adaptation and, in cases of multiple independent weed origins, the factors influencing parallel evolution, they remain understudied. For my thesis work, I asked whether populations of common sunflower (Helianthus annuus) growing as agricultural weeds have adapted to the unique challenges posed by cultivated fields. In a common garden, I compared paired weedy and wild (i.e., non-agricultural) populations, collected over a latitudinal transect from Canada to Kansas, USA. Weedy populations grew faster and flowered earlier than wild populations, suggesting an evolutionary shift in life history strategy to prioritize growth and reproduction. One wild population from a wetland site showed the same pattern, indicating that wild sunflowers may face similar selection pressures in certain contexts. I then used whole genome resequencing to investigate the extent of parallel genetic differentiation between weedy and wild populations. Using two different metrics, a “cluster separation score” based on genetic distance matrices and FST, I identified a list of 148 differentiated genomic regions, though our analysis lacked power to distinguish true positives after correction for multiple testing, and therefore these regions are only suggestively linked to adaptation to the agricultural environment. Genes overlapping these regions were varied and included those involved in plant stress responses, flowering time genes and transporter genes linked to herbicide resistance. To connect phenotype to genotype, I conducted a genome-wide association analysis of glyphosate resistance, a trait likely critical for the success of weedy populations. At a glyphosate application rate of 0.5 kg a.e. ha-¹, or half the rate typically applied by a farmer, resistance segregated in the mapping population, with surviving plants (78.5%) showing a variety of symptoms. Mapping identified 68 SNPs suggestively associated with resistance, and three transporter proteins, among other genes.
The monadic theory of order
Creators: name: Shelah, Saharon
Publisher: name: arXiv
Year: 2023
Subjects: subject: Logic (math.LO)
subject: FOS: Mathematics

description: We deal with the monadic (second-order) theory of order. We prove all known results in a unified way, show a general way of reduction, prove more results and show the limitation on extending them. We prove (CH) that the monadic theory of the real order is undecidable. Our methods are model-theoretic, and we do not use automaton theory. This is a slightly corrected version of a very old work.
The repulsive nature of naked singularities from the point of view of Quantum Mechanics
Creators: name: Batic, D.
name: Nowakowski, M.
Publisher: name: arXiv
Year: 2010
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We use the Dirac equation coupled to a background metric to examine what happens to quantum mechanical observables like the probability density and the radial current in the vicinity of a naked singularity of the Reissner-Nordström type. We find that the wave function of the Dirac particle is regular in the point of the singularity. We show that the probability density is exactly zero at the singularity reflecting quantum-mechanically the repulsive nature of the naked singularity. Furthermore, the surface integral of the radial current over a sphere in the vicinity of the naked singularity turns out to be also zero.
description: 11 pages
Acetylenic sesquiterpenoids from cultures of the basidiomycete Stereum cf. hirsutum BCC 26597
Creators: name: Isaka, Masahiko
name: Yangchum, Arunrat
name: Choeyklin, Rattaket
name: Anaphon, Sakaokan
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: Science Policy
subject: Hematology
subject: Plant Biology

description: A new acetylenic sesquiterpenoid, stereyne A (1), and its acetonide derivative, stereyne B (2), were isolated from cultures of the basidiomycete Stereum cf. hirsutum BCC 26597. The structures were elucidated by spectroscopic analysis and a chemical correlation. Their absolute configurations were determined by application of the modified Mosher’s method. They represent new structural type of sesquiterpenoids from Stereum.
Not so fast—building resilience in place : BRAC (Bangladesh) and the rise of social enterprise in the world's largest non-governmental nonprofit organization
Creators: name: Koerner, Jacqueline Laura
Publisher: name: University of British Columbia
Year: 2018

description: Against a backdrop of accelerating globalization, poverty in the Global South has declined over the past thirty years. However, a singular focus on short-term economic gain has advanced socio-economic-environmental injustices, as evidenced by the growing income inequality gap, greater job insecurity, and environmental degradation. To address these issues, government, businesses, and civil society need to find scalable approaches that are inclusive of the broader needs of society and the environment. This study is ‘solution-seeking’. It examines one non-profit organization (NPO), BRAC, founded and headquartered in Dhaka, Bangladesh. BRAC fosters locally based and globally significant ways to achieve durable economic, environmental, and social initiatives. Its work is accomplished through both charitable programs and revenue generating mission-aligned social enterprises operated from within the NPO. This research investigates qualities of resilience and place in BRAC. In reviewing literatures that engage with resilience, I observed that most resilience literature is directed at social-ecological systems and place as a local-scale, community phenomenon; there is scant mention of social-economic place linked to cross-scale interactions. Through two separate case studies, I examine how BRAC: • Uses place to build organizational resilience and greater resilience in the lives of its clients; • Engages in cross-scale interaction; • Employs both slow and fast variables in its work in pursuit of transformation toward more inclusion. My research demonstrates that for BRAC place matters. This is not quaint, nostalgic localism but essential and difficult work to create lives of dignity in a globalized world. ii My research findings indicate that attending to slower variables in resilience building in BRAC is more challenging today due to the pressure of market-based enterprise activities and the need to reduce dependence on aid and philanthropy. My research further shows that operating social enterprises within charitable NPO offers a strong platform for continuously including the most marginalized. In order to do this, BRAC needs to promote risk taking and experimentation in its enterprises just as it does in its development programs. Building inclusive social enterprises is challenging work that takes time and significant donor support to be inclusive, scalable, and sustainable over time.
Molecular profiling and bioactive potential of an endophytic fungus Aspergillus sulphureus isolated from Sida acuta: a medicinal plant
Creators: name: M. Murali
name: C. Mahendra
name: P. Hema
name: N. Rajashekar
name: A. Nataraju
name: M. S. Sudarshana
name: K. N. Amruthesh
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Context:Sida acuta Burm.f. (Malvaceae) extracts are reported to have applications against malaria, diuretic, antipyretic, nervous and urinary diseases. No fungal endophytes of S. acuta are reported. Objective: Isolation, identification and evaluation of antibacterial, antioxidant, anticancer and haemolytic potential of fungal endophytes from the ethnomedcinal plant S. acuta. Materials and methods:Sida acuta stem segments were placed on PDA medium to isolate endophytic fungi. The fungus was identified by genomic DNA analysis and phylogenetic tree was constructed using ITS sequences (GenBank) to confirm species. The antibacterial efficacy of Aspergillus sulphureus MME12 ethyl acetate extract was tested against Gram-positive and Gram-negative pathogenic bacteria. DPPH free radical scavenging activity, anticancer and DNA fragmentation against EAC cells, and direct haemolytic activity (100–500 μg/mL) using human erythrocytes were determined. Results and discussion: The ethyl acetate extract of A. sulphureus (Fresen.) Wehmer (Trichocomaceae) demonstrated significant antibacterial potential against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Salmonella typhi compared to streptomycin. MIC against test pathogens was in the range of 15.6–62.5 μg/mL. The antioxidant results revealed significant RSA from 12.43% to 62.02% (IC50 = 350.4 μg/mL, p ≤ 0.05). MME12 offered considerable inhibition of EAC proliferation (23% to 84%, IC50 = 216.7 μg/mL, p ≤ 0.05) supported by DNA fragmentation studies. The extract also offered insignificant haemolysis (5.6%) compared to Triton X-100. Conclusions: A single endophytic fungus, A. sulphureus MME12 was isolated and identified using molecular profiling. The above-mentioned findings support the pharmacological application of A. sulphureus MME12 extract and demand for purification of the active principle(s).
Dynamic score driven independent component analysis
Creators: name: Hafner, Christian M.
name: Herwartz, Helmut
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy

description: A model for dynamic independent component analysis is introduced where the dynamics are driven by the score of the pseudo likelihood with respect to the rotation angle of model innovations. While conditional second moments are invariant with respect to rotations, higher conditional moments are not, which may have important implications for applications. The pseudo maximum likelihood estimator of the model is shown to be consistent and asymptotically normally distributed. A simulation study reports good finite sample properties of the estimator, including the case of a mis-specification of the innovation density. In an application to a bivariate exchange rate series of the Euro and the British Pound against the US Dollar, it is shown that the model-implied conditional portfolio kurtosis largely aligns with narratives on financial stress as a result of the global financial crisis in 2008, the European sovereign debt crisis (2010-2013) and early rumors signalling the UK to leave the European Union (2017). These insights are consistent with a recently proposed model that associates portfolio kurtosis with a geopolitical risk factor.
Nucleon, Delta and Omega excited state spectra at three pion mass values
Creators: name: Bulava, John
name: Edwards, Robert G.
name: Joó, Bálint
name: Richards, David G.
name: Engelson, Eric
name: Lin, Huey-Wen
name: Morningstar, Colin
name: Wallace, Stephen J.
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: The energies of the excited states of the Nucleon, Delta and Omega are computed in lattice QCD, using two light quarks and one strange quark on anisotropic lattices. The calculations are performed at three values of the pion mass: 392(4), 438(3) and 521(3) MeV. We employ the variational method with a basis of about ten interpolating operators enabling six energies to be distinguished clearly in each irreducible representation of the octahedral group. We compare our calculations of nucleon excited states with the low-lying experimental spectrum. There is reasonable agreement for the pattern of states.
description: The XXVIII International Symposium on Lattice Field Theory, June 14-19, 2010, Villasimius, Sardinia Italy // 7 pages, 3 figures
The Monty Hall Problem is not a Probability Puzzle (it's a challenge in mathematical modelling)
Creators: name: Gill, Richard D.
Publisher: name: arXiv
Year: 2010
Subjects: subject: History and Overview (math.HO)
subject: Applications (stat.AP)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences
subject: 97K50

description: Suppose you're on a game show, and you're given the choice of three doors: Behind one door is a car; behind the others, goats. You pick a door, say No. 1, and the host, who knows what's behind the doors, opens another door, say No. 3, which has a goat. He then says to you, ``Do you want to pick door No. 2?'' Is it to your advantage to switch your choice? The answer is ``yes'' but the literature offers many reasons why this is the correct answer. The present paper argues that the most common reasoning found in introductory statistics texts, depending on making a number of ``obvious'' or ``natural'' assumptions and then computing a conditional probability, is a classical example of solution driven science. The best reason to switch is to be found in von Neumann's minimax theorem from game theory, rather than in Bayes' theorem.
description: Mathematical Humour, Mathematical Education. Submitted to Statistica Neerlandica
On structure of homogenenous Wick ideals in Wick $*$-algebras with braided coefficients
Creators: name: Ostrovskyi, Vasyl
name: Proskurin, Danil
name: Savchuk, Yurii
name: Turowska, Lyudmila
Publisher: name: arXiv
Year: 2011
Subjects: subject: Operator Algebras (math.OA)
subject: Functional Analysis (math.FA)
subject: Representation Theory (math.RT)
subject: FOS: Mathematics

description: We study the structure of Wick homogenenous ideals of higher degrees in quadratic algebras allowing Wick ordering. We present a method how to construct a homogeneous Wick ideal $\mathcal{I}_{n+1}$ of degree $n+1$ out of a homogeneous Wick ideal $\mathcal{I}_n$ of degree $n$ so that $\mathcal{I}_{n+1}\subset\mathcal{I}_n$. We show that in some particular cases our procedure allows one to get a description of the largest homogeneous Wick ideals of higher degrees having generators of the largest quadratic Wick ideal only. Finally we study classes of $*$-representations of Wick version of CCR annihilating certain homogeneous Wick ideals of degree higher than $2$.
Product-limit estimators of the gap time distribution of a renewal process under different sampling patterns
Creators: name: Gill, Richard D.
name: Keiding, Niels
Publisher: name: arXiv
Year: 2010
Subjects: subject: Applications (stat.AP)
subject: Methodology (stat.ME)
subject: FOS: Computer and information sciences

description: Nonparametric estimation of the gap time distribution in a simple renewal process may be considered a problem in survival analysis under particular sampling frames corresponding to how the renewal process is observed. This note describes several such situations where simple product limit estimators, though inefficient, may still be useful.