cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
(101756) Selina Ann Radford
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Inhibition of glutamine metabolism accelerates resolution of acute lung injury
Creators: name: Vigeland, C.L.
name: Powell, J.D.
name: Chan-Li, Y.
name: Beggs, H.S.
name: Horton, M.R.
name: Collins, S.L.
name: Doerschuk, C.M.
Publisher: name: American Physiological Society
Year: 2019

description: Despite recent advances, acute respiratory distress syndrome (ARDS) remains a severe and often fatal disease for which there is no therapy able to reduce the underlying excessive lung inflammation or enhance resolution of injury. Metabolic programming plays a critical role in regulating inflammatory responses. Due to their high metabolic needs, neutrophils, macrophages, and lymphocytes rely upon glutamine metabolism to support activation and function. Additionally, during times of physiologic stress, nearly all cells, including fibroblasts and epithelial cells, require glutamine metabolism. We hypothesized that inhibiting glutamine metabolism reduces lung inflammation and promotes resolution of acute lung injury. Lung injury was induced by instilling lipopolysaccharide (LPS) intratracheally. To inhibit glutamine metabolism, we administered a glutamine analogue, 6-diazo-5-oxo-L-norleucine (DON) that binds to glutamine-utilizing enzymes and transporters, after injury was well established. Treatment with DON led to less lung injury, fewer lung neutrophils, lung inflammatory and interstitial macrophages, and lower levels of proinflammatory cytokines and chemokines at 5 and/or 7 days after injury. Additionally, DON led to earlier expression of the growth factor amphiregulin and more rapid recovery of LPS-induced weight loss. Thus, DON reduced lung inflammation and promoted resolution of injury. These data contribute to our understanding of how glutamine metabolism regulates lung inflammation and repair, and identifies a novel target for future therapies for ARDS and other inflammatory lung diseases.
title: Hypersensitivity Pneumonitis : a diagnosis underestimated
Creators: name: Rispal, Adrien
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Pathology
subject: Inflammation
subject: Acute
subject: eLearning
subject: CT-High Resolution
subject: CT
subject: Thorax
subject: Respiratory system
subject: Lung

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The purpose of our educational exhibit is to: Underline HP diagnosis issues; Remind ourselves about the acute and chronic HP semiology and the leading role of a CT scan within the diagnostic process, Describe main differential...
Neuropilin-2 regulates airway inflammatory responses to inhaled lipopolysaccharide
Creators: name: Doerschuk, C.M.
name: Lauzier, D.C.
name: Peden, D.B.
name: Moran, T.P.
name: Ghio, A.J.
name: Immormino, R.M.
name: Cook, D.N.
name: Hernandez, M.L.
name: Alexis, N.E.
name: Nakano, H.
name: Tilley, S.L.
Publisher: name: American Physiological Society
Year: 2018

description: Neuropilins are multifunctional receptors that play important roles in immune regulation. Neuropilin-2 (NRP2) is expressed in the lungs, but whether it regulates airway immune responses is unknown. Here, we report that Nrp2 is weakly expressed by alveolar macrophages (AMs) in the steady state but is dramatically upregulated following in vivo lipopolysaccharide (LPS) inhalation. Ex vivo treatment of human AMs with LPS also increased NRP2 mRNA expression and cell-surface display of NRP2 protein. LPS-induced Nrp2 expression in AMs was dependent upon the myeloid differentiation primary response 88 signaling pathway and the transcription factor NF-κB. In addition to upregulating display of NRP2 on the cell membrane, inhaled LPS also triggered AMs to release soluble NRP2 into the airways. Finally, myeloid-specific ablation of NRP2 resulted in increased expression of the chemokine (C-C motif) ligand 2 (Ccl2) in the lungs and prolonged leukocyte infiltration in the airways following LPS inhalation. These findings suggest that NRP2 expression by AMs regulates LPS-induced inflammatory cell recruitment to the airways and reveal a novel role for NRP2 during innate immune responses in the lungs.
Detection and Characterization of Extrasolar Planets through Mean-Motion Resonances: Simulations of Hypothetical Debris Disks
Creators: name: Tabeshian, Maryam
name: Wiegert, Paul
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The gravitational influence of a planet on a nearby disk provides a powerful tool for detecting and studying extrasolar planetary systems. Here we demonstrate that gaps can be opened in dynamically cold debris disks at the mean-motion resonances of an orbiting planet. The gaps are opened away from the orbit of the planet itself, revealing that not all disk gaps need contain a planetary body. These gaps are large and deep enough to be detectable in resolved disk images for a wide range of reasonable disk-planet parameters, though we are not aware of any such gaps detected to date. The gap shape and size are diagnostic of the planet location, eccentricity and mass, and allow one to infer the existence of unseen planets, as well as many important parameters of both seen and unseen planets in these systems. We present expressions to allow the planetary mass to be calculated from observed gap width and location.
description: minor revisions to reflect accepted ApJ version
Non-perturbative tests of continuum HQET through small-volume two-flavour QCD
Creators: name: Fritzsch, P.
name: Garron, N.
name: Heitger, J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the heavy quark mass dependence of selected observables constructed from heavy-light meson correlation functions in small-volume two-flavour lattice QCD after taking the continuum limit. The light quark mass is tuned to zero, whereas the range of available heavy quark masses $m_h$ covers a region extending from around the charm to beyond the bottom quark mass scale. This allows entering the asymptotic mass-scaling regime as $1/m_h \to 0$ and performing well-controlled extrapolations to the infinite-mass limit. Our results are then compared to predictions obtained in the static limit of continuum Heavy Quark Effective Theory (HQET), in order to verify non-perturbatively that HQET is an effective theory of QCD. While in general we observe a nice agreement at the few-% level, we find it to be less convincing for the small-volume pseudoscalar decay constant when perturbative matching is involved.
description: 42 pages, 10 figures, 12 tables; JHEP style
title: Spine imaging tecniques - learning material for radiography and radiotherapy students
Creators: name: Karsikko, Merja
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Musculoskeletal spine
subject: Neuroradiology spine
subject: Digital radiography
subject: Teleradiology
subject: Education
subject: eLearning
subject: Staging
subject: Education and training

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To produce a high quality and visual online learning material of the cervical, thoracic and lumbar spine imaging for the radiography and radiotherapy students in Helsinki Metropolia University of Applied Sciences in Finland (Figure...
(101753) Charlotte Louisa La Trobe
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A Rnd3/p190RhoGAP pathway regulates RhoA activity in idiopathic pulmonary fibrosis fibroblasts
Creators: name: Monaghan-Benson, E.
name: Doerschuk, C.M.
name: Wittchen, E.S.
name: Burridge, K.
Publisher: name: American Society for Cell Biology
Year: 2018

description: Idiopathic pulmonary fibrosis (IPF) is an incurable disease of the lung that is characterized by excessive deposition of extracellular matrix (ECM), resulting in disruption of normal lung function. The signals regulating fibrosis include both transforming growth factor beta (TGF-β) and tissue rigidity and a major signaling pathway implicated in fibrosis involves activation of the GTPase RhoA. During studies exploring how elevated RhoA activity is sustained in IPF, we discovered that not only is RhoA activated by profibrotic stimuli but also that the expression of Rnd3, a major antagonist of RhoA activity, and the activity of p190RhoGAP (p190), a Rnd3 effector, are both suppressed in IPF fibroblasts. Restoration of Rnd3 levels in IPF fibroblasts results in an increase in p190 activity, a decrease in RhoA activity and a decrease in the overall fibrotic phenotype. We also find that treatment with IPF drugs nintedanib and pirfenidone decreases the fibrotic phenotype and RhoA activity through up-regulation of Rnd3 expression and p190 activity. These data provide evidence for a pathway in IPF where fibroblasts down-regulate Rnd3 levels and p190 activity to enhance RhoA activity and drive the fibrotic phenotype.
High Dimensional Unitary Transformations and Boson Sampling on Temporal Modes using Dispersive Optics
Creators: name: Pant, Mihir
name: Englund, Dirk
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We present methods which allow orders of magnitude increase in the number of modes in linear optics experiments by moving from spatial encoding to temporal encoding and using dispersion. This enables significant practical advantages for linear quantum optics and Boson Sampling experiments. Passing consecutively heralded photons through time-independent dispersion and measuring the output time of the photons is equivalent to a Boson Sampling experiment for which no efficient classical algorithm is reported, to our knowledge. With time-dependent dispersion, it is possible to implement arbitrary single-particle unitaries. Given the relatively simple requirements of these schemes, they provide a path to realizing much larger linear quantum optics experiments including post-classical Boson Sampling machines.
title: Imaging principles of spondylolysis
Creators: name: Soylu Ozturk, Esra
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Connective tissue disorders
subject: Diagnostic procedure
subject: SPECT
subject: Digital radiography
subject: CT
subject: Musculoskeletal spine

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: In this exhibit, review of the current concepts, pathogenesis, epidemiology, general treatment guidelines, besides an extensive discussion and review of the imaging principles for the diagnosis of spondylolysis was...
Blocking CXCL1-dependent neutrophil recruitment prevents immune damage and reduces pulmonary bacterial infection after inhalation injury
Creators: name: Doerschuk, C.M.
name: Dunn, J.L.M.
name: Glenn, L.I.
name: Malfitano, M.M.
name: Jones, S.W.
name: Stepp, W.H.
name: Kartchner, L.B.
name: Maile, R.
name: Cairns, B.A.
Publisher: name: NLM (Medline)
Year: 2018

description: Smoke inhalation associated with structural fires, wildfires, or explosions leads to lung injury, for which innovative and clinically relevant animal models are needed to develop effective therapeutics. We have previously reported that damage-associated molecular patterns (DAMPs) and anti-inflammatory cytokines correlate with infectious complications in patients diagnosed with inhalational injury. In this study, we describe a novel and translational murine model of acute inhalational injury characterized by an accumulation of protein and neutrophils in the bronchoalveolar space, as well as histological evidence of tissue damage. Mice were anesthetized, and a cannula was placed in the trachea and exposed to smoldering plywood smoke three times for 2-min intervals in a smoke chamber. Here we demonstrate that this model recapitulates clinically relevant phenotypes, including early release of double-stranded DNA (dsDNA), IL-10, monocyte chemoattractant protein (MCP)-1, and CXCL1 along with neutrophilia early after injury, accompanied by subsequent susceptibility to opportunistic infection with Pseudomonas aeruginosa. Further investigation of the model, and in turn a reanalysis of patient samples, revealed a late release of the DAMP hyaluronic acid (HA) from the lung. Using nitric oxide synthase-deficient mice, we found that Nos2 was required for increases in IL-10, MCP-1, and HA following injury but not release of dsDNA, CXCL1 expression, early neutrophilia, or susceptibility to opportunistic infection. Depletion of CXCL1 attenuated early neutrophil recruitment, leading to decreased histopathology scores and improved bacterial clearance in this model of smoke inhalation. Together, these data highlight the potential therapeutic benefit of attenuating neutrophil recruitment in the first 24 h after injury in patients.
title: The rising incidence of CVST with the advent of heat wave in tropical countries
Creators: name: Arooj, Shumaila
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Obstruction / Occlusion
subject: Outcomes analysis
subject: MR
subject: CNS

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: By reviewing this scientific exhibit, viewer will be: able to recognize the presence of venous sinus thrombosis on baseline MR images as well as MRV. Able to associate increase in incidence of CVST with hemoconcentration secondary to dehydration...
Biomarkers of exposure to new and emerging tobacco delivery products
Creators: name: Blair, I.A.
name: Schick, S.F.
name: Blount, B.C.
name: El Hellani, A.
name: Gomez, J.C.
name: Bhatnagar, A.
name: Jacob, P., III
name: Lorkiewicz, P.K.
name: Hecht, S.S.
name: Doerschuk, C.M.
name: Saliba, N.A.
name: Srivastava, S.
name: Benowitz, N.L.
name: Foulds, J.
name: Pappas, R.S.
name: St. Helen, G.
name: Wang, L.
name: Ghosh, A.
name: Jatlow, P.
name: Martin, J.R.
name: Kimmel, H.L.
name: Mesaros, C.
name: Tarran, R.
name: Bernert, J.T.
Publisher: name: American Physiological Society
Year: 2017

description: Accurate and reliable measurements of exposure to tobacco products are essential for identifying and confirming patterns of tobacco product use and for assessing their potential biological effects in both human populations and experimental systems. Due to the introduction of new tobaccoderived products and the development of novel ways to modify and use conventional tobacco products, precise and specific assessments of exposure to tobacco are now more important than ever. Biomarkers that were developed and validated to measure exposure to cigarettes are being evaluated to assess their use for measuring exposure to these new products. Here, we review current methods for measuring exposure to new and emerging tobacco products, such as electronic cigarettes, little cigars, water pipes, and cigarillos. Rigorously validated biomarkers specific to these new products have not yet been identified. Here, we discuss the strengths and limitations of current approaches, including whether they provide reliable exposure estimates for new and emerging products. We provide specific guidance for choosing practical and economical biomarkers for different study designs and experimental conditions. Our goal is to help both new and experienced investigators measure exposure to tobacco products accurately and avoid common experimental errors. With the identification of the capacity gaps in biomarker research on new and emerging tobacco products, we hope to provide researchers, policymakers, and funding agencies with a clear action plan for conducting and promoting research on the patterns of use and health effects of these products.
Hybrid resonance and long-time asymptotic of the solution to Maxwell's equations
Creators: name: Després, Bruno
name: Weder, Ricardo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: 35Q61, 78A25

description: We study the long-time asymptotic of the solutions to Maxwell's equation in the case of a upper-hybrid resonance in the cold plasma model. We base our analysis in the transfer to the time domain of the recent results of B. Després, L.M. Imbert-Gérard and R. Weder, J. Math. Pures Appl. {\bf 101} ( 2014) 623-659, where the singular solutions to Maxwell's equations in the frequency domain were constructed by means of a limiting absorption principle and a formula for the heating of the plasma in the limit of vanishing collision frequency was obtained. Currently there is considerable interest in these problems, in particular, because upper-hybrid resonances are a possible scenario for the heating of plasmas, and since they can be a model for the diagnostics involving wave scattering in plasmas.
description: This published version has been edited to improve the presentation of the results
(101750) Clara Stooke
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Technical aspects of cerebral PET/CT with β-amyloid tracers in Alzheimer's disease
Creators: name: Giudice, Debora
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Nuclear medicine
subject: Molecular imaging
subject: Neuroradiology brain
subject: PET-CT
subject: Technical aspects
subject: Molecular imaging
subject: Dementia

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The work aims to illustrate the professional aspects related to the figure of the Radiographer during the various phases of a PET-CT brain scan using β-amyloid tracers in the examination of Alzheimer's Disease (AD). The aims are the following: Care...
Foxp31 regulatory t cell expression of keratinocyte growth factor enhances lung epithelial proliferation
Creators: name: Tune, M.K.
name: Mock, J.R.
name: Dial, C.F.
name: Doerschuk, C.M.
Publisher: name: American Thoracic Society
Year: 2017

description: Repair of the lung epithelium after injury is a critical component for resolution; however, the processes necessary to drive epithelial resolution are not clearly defined. Published data demonstrate that Foxp31 regulatory T cells (Tregs) enhance alveolar epithelial proliferation after injury, and Tregs in vitro directly promote type II alveolar epithelial cell (AT2) proliferation, in part by a contactindependent mechanism. Therefore, we sought to determine the contribution of Treg-specific expression of a growth factor that is known to be important in lung repair, keratinocyte growth factor (kgf). The data demonstrate that Tregs express kgf and that Treg-specific expression of kgf regulates alveolar epithelial proliferation during the resolution phase of acute lung injury and in a model of regenerative alveologenesis in vivo. In vitro experiments demonstrate that AT2 cells cocultured with Tregs lacking kgf have decreased rates of proliferation compared with AT2 cells cocultured with wild-type Tregs. Moreover, Tregs isolated from lung tissue and grown in culture express higher levels of two growth factors that are important for lung repair (kgf and amphiregulin) compared with Tregs isolated from splenic tissue. Lastly, Tregs isolated from human lung tissue can be stimulated ex vivo to induce kgf expression. This study reveals mechanisms by which Tregs direct tissuereparative effects during resolution after acute lung injury, further supporting the emerging role of Tregs in tissue repair.
Activating integrins isn't always "beta" for neutrophil migration!
Creators: name: Gomez, J.C.
name:  Doerschuk, C.M.
Publisher: name: American Thoracic Society
Year: 2017

description: The lungs possess extraordinary defenses against bacteria and other stimuli. Initial mechanisms of host defense include the very effective mucociliary escalator and the alveolar macrophages,which clearmany stimuli without inducing an inflammatory response and recruitment of circulating leukocytes. When these defenses are overwhelmed, epithelial cells andmacrophages call in help fromoutside the lungs. In response to bacteria, neutrophils are usually first to arrive, and their response is quick, recognizing a need within minutes.
title: Timing and mechanisms of Late Mesozoic to Early Cenozoic exhumation and uplift in Central Europe
Creators: name:  von Eynatten ,  Hilmar
name:  Kley ,  Jonas
name:  Dunkl ,  István
Publisher: name: Deutsche Geologische Gesellschaft - Geologische Vereinigung e.V. (DGGV)
Year: 2021

description: Widespread exhumation and uplift affected Central Europe in Late Cretaceous to Paleogene time (e.g. Kley and Voigt, 2008, Geology, 36, 839-842). The area involved includes thrust-related basement uplifts and inverted Mesozoic basins and extends at least from the Rhenish Massif to the Bohemian Massif and from the Black Forest/Vosges to the North German Basin. Exhumation and basin inversion started at approx. 95 Ma based on stratigraphic constraints (Voigt et al. 2021, Solid Earth, https://se.copernicus.org/preprints/se-2020-188), well in line with ZHe cooling data (e.g. von Eynatten et al. 2019, International Journal of Earth Sciences, 108, 2097-2111). Late Cretaceous SW-NE directed basement thrusting (e.g. Harz Mountains, Thuringian Forest, Flechtingen High) peaked around 85 to 70 Ma. Thermochronological data (AFT, AHe) from the Triassic uplands between the basement highs reveal km-scale exhumation of a wider region, at least 250-300 km across, suggesting long-wavelength domal uplift (von Eynatten et al. 2021, Solid Earth, 12, 935-958). This domal uplift is dated slightly later at 75 to 55 Ma and calls for a separate mechanism superimposed on the Late Cretaceous compressional event. Based on timing, spatial extent of the doming area and thickness of eroded strata (3-4 km), possible mechanisms are evaluated for their contribution to exhumation and uplift. While shortening and crustal thickening may explain 50% of the domal uplift at most, upwelling asthenosphere driving dynamic topography appears capable of producing uplift and erosion of the required magnitude, wavelength and rate.
title: Imaging approaches for pediatric ischemic stroke
Creators: name: Soylu Ozturk, Esra
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Ischaemia / Infarction
subject: Education
subject: MR-Angiography
subject: MR
subject: CT
subject: Vascular
subject: Paediatric
subject: Neuroradiology brain

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: The exhibit will illustrate imaging findings of the pediatric acute ischemic stroke (AIS) on CT, MRI, MR angiography and propose a diagnosis strategy for different clinical...
Overview: Systemic Inflammatory Response Derived From Lung Injury Caused by SARS-CoV-2 Infection Explains Severe Outcomes in COVID-19
Creators: name: de Santis Santiago, R.
name: Schmidt, N.W.
name: Hagan, R.S.
name: Polidoro, R.B.
Publisher: name: Frontiers Media S.A.
Year: 2020

description: Most SARS-CoV2 infections will not develop into severe COVID-19. However, in some patients, lung infection leads to the activation of alveolar macrophages and lung epithelial cells that will release proinflammatory cytokines. IL-6, TNF, and IL-1β increase expression of cell adhesion molecules (CAMs) and VEGF, thereby increasing permeability of the lung endothelium and reducing barrier protection, allowing viral dissemination and infiltration of neutrophils and inflammatory monocytes. In the blood, these cytokines will stimulate the bone marrow to produce and release immature granulocytes, that return to the lung and further increase inflammation, leading to acute respiratory distress syndrome (ARDS). This lung-systemic loop leads to cytokine storm syndrome (CSS). Concurrently, the acute phase response increases the production of platelets, fibrinogen and other pro-thrombotic factors. Systemic decrease in ACE2 function impacts the Renin-Angiotensin-Kallikrein-Kinin systems (RAS-KKS) increasing clotting. The combination of acute lung injury with RAS-KKS unbalance is herein called COVID-19 Associated Lung Injury (CALI). This conservative two-hit model of systemic inflammation due to the lung injury allows new intervention windows and is more consistent with the current knowledge.
(101751) William Frank Page
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Sentiment Analysis For Modern Standard Arabic And Colloquial
Creators: name: Ibrahim, Hossam S.
name: Abdou, Sherif M.
name: Gheith, Mervat
Publisher: name: arXiv
Year: 2015
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences

description: The rise of social media such as blogs and social networks has fueled interest in sentiment analysis. With the proliferation of reviews, ratings, recommendations and other forms of online expression, online opinion has turned into a kind of virtual currency for businesses looking to market their products, identify new opportunities and manage their reputations, therefore many are now looking to the field of sentiment analysis. In this paper, we present a feature-based sentence level approach for Arabic sentiment analysis. Our approach is using Arabic idioms/saying phrases lexicon as a key importance for improving the detection of the sentiment polarity in Arabic sentences as well as a number of novels and rich set of linguistically motivated features contextual Intensifiers, contextual Shifter and negation handling), syntactic features for conflicting phrases which enhance the sentiment classification accuracy. Furthermore, we introduce an automatic expandable wide coverage polarity lexicon of Arabic sentiment words. The lexicon is built with gold-standard sentiment words as a seed which is manually collected and annotated and it expands and detects the sentiment orientation automatically of new sentiment words using synset aggregation technique and free online Arabic lexicons and thesauruses. Our data focus on modern standard Arabic (MSA) and Egyptian dialectal Arabic tweets and microblogs (hotel reservation, product reviews, etc.). The experimental results using our resources and techniques with SVM classifier indicate high performance levels, with accuracies of over 95%.
description: International Journal on Natural Language Computing (IJNLC) Vol. 4, No.2,April 2015
Transformation of environmental and legal education and environmental education in the context of the constitution of the ideology of animal rights//Трансформация эколого-правового образования и экологического воспитания в контексте конституирования идеологии прав животных / Д. И. Наумов, С. В. Шошин // Трансформация правовых институтов и методов обеспечения санитарно-эпидемиологического благополучия: Материалы конференции – Саратов: "Саратовский источник", 2021. – С. 157-161.
Creators: name: Shoshin, Serguei
name: Naumov, Dmitry
Publisher: name: figshare
Year: 2022
Subjects: subject: 50199 Ecological Applications not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 50101 Ecological Impacts of Climate Change
subject: Ecology
subject: FOS: Biological sciences
subject: 50102 Ecosystem Function
subject: 50203 Environmental Education and Extension
subject: 50204 Environmental Impact Assessment
subject: 50205 Environmental Management
subject: 50206 Environmental Monitoring
subject: 50207 Environmental Rehabilitation (excl. Bioremediation)
subject: Environmental Science
subject: 50299 Environmental Science and Management not elsewhere classified
subject: 59999 Environmental Sciences not elsewhere classified

description: The authors propose a new scientific problem related to the legal regulation of animal rights. From the legal regulation of animals as a thing used in Russia and the Republic of Belarus today, it is recommended to move to more humane legal regimes. Corresponding changes are also worthy of inclusion in plans for the development of environmental and legal education. Moreover, these categories can be included in the structure of modern environmental education.
title: Breast ultrasound in patients with mastectomy and reconstructive surgery, what a radiologist needs to know
Creators: name: Pineiro, Tiare
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Breast
subject: Ultrasound
subject: Ultrasound-Power Doppler
subject: Education
subject: Biopsy
subject: Surgery
subject: Cancer
subject: Prostheses
subject: Multidisciplinary cancer care

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: - To show a brief description of different breast reconstruction techniques - To recognize anatomic changes depending on the type of surgery performed - To identify post-operative benign lesions by ultrasound and their typical ultrasonic...
title: Abdominal emergencies after hematopoietic stem cell transplantation. Radiographic features.
Creators: name: Pesquera Muñoz, Alvaro
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Contrast agent-intravenous
subject: Diagnostic procedure
subject: Ultrasound-Colour Doppler
subject: CT
subject: Haematologic
subject: Emergency
subject: Abdomen
subject: Contrast agent-oral
subject: Transplantation

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: - To describe the imaging findings of the most common abdominal diseases in patients with hematopoietic stem cell transplantation. - To explain the pathophysiology of the complications of hematopoietic stem cell transplantation...
Do $n$-Lie algebras have universal enveloping algebras
Creators: name: Garcia-Martinez, Xabier
name: Turdibaev, Rustam
name: van der Linden, Tim
Publisher: name: arXiv
Year: 2015
Subjects: subject: Rings and Algebras (math.RA)
subject: FOS: Mathematics
subject: 17B35, 17A42

description: The aim of this paper is to investigate in which sense, for $n\geq 3$, $n$-Lie algebras admit universal enveloping algebras. There have been some attempts at a construction (see [10] and [5]) but after analysing those we come to the conclusion that they cannot be valid in general. We give counterexamples and sufficient conditions. We then study the problem in its full generality, showing that universality is incompatible with the wish that the category of modules over a given $n$-Lie algebra $L$ is equivalent to the category of modules over the associated algebra $U(L)$. Indeed, an associated algebra functor $U \colon \text{$n$-}\mathsf{Lie}_{\mathbb{K}} \to \mathsf{Alg}_{\mathbb{K}}$ inducing such an equivalence does exist, but this kind of functor never admits a right adjoint. We end the paper by introducing a (co)homology theory based on the associated algebra functor $U$.
(101752) Sir George Beresford-Stoke
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Pancreatic fibrosis and sarcopenia: MRI and CT diagnostic value. First experience.
Creators: name: Kemesiene, Jurate
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Tissue characterisation
subject: Pathology
subject: Outcomes
subject: Diagnostic procedure
subject: Biopsy
subject: MR
subject: CT
subject: Pancreas
subject: Abdomen

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: Pancreatic fibrosis is a histological feature of chronic pancreatitis. Moreover, it develops during the course of pancreatic cancer. The only method that can be used to determine the level of PF accurately is histological examination of pancreatic...
TBK1 Limits mTORC1 by Promoting Phosphorylation of Raptor Ser877
Creators: name: Serafin, D.S.
name: Graves, L.M.
name: Castillo, J.
name: Baldwin, A.S.
name: Antonia, R.J.
name: Hagan, R.S.
name: Liu, P.
name: Herring, L.E.
Publisher: name: Nature Publishing Group
Year: 2019

description: While best known for its role in the innate immune system, the TANK-binding kinase 1 (TBK1) is now known to play a role in modulating cellular growth and autophagy. One of the major ways that TBK1 accomplishes this task is by modulating the mechanistic Target of Rapamycin (mTOR), a master regulator that when activated promotes cell growth and inhibits autophagy. However, whether TBK1 promotes or inhibits mTOR activity is highly cell type and context dependent. To further understand the mechanism whereby TBK1 regulates mTOR, we tested the hypothesis that TBK1 phosphorylates a key component of the mTOR complex 1 (mTORC1), Raptor. Using kinase assays coupled with mass spectrometry, we mapped the position of the TBK1 dependent phosphorylation sites on Raptor in vitro. Among the sites identified in vitro, we found that TBK1 promotes Raptor Ser877 phosphorylation in cells both basally and in response to pathogen-associated molecules known to induce TBK1 activity. The levels of Raptor Ser877 phosphorylation were inversely correlated with the levels of mTOR activity. Expression of a mutant Raptor that could not be phosphorylated at Ser877 led to an increase in mTORC1 activity. We conclude that TBK1 limits mTORC1 activity by promoting Raptor Ser877 phosphorylation.
Fast Sparsely Synchronized Brain Rhythms in A Scale-Free Neural Network
Creators: name: Kim, Sang-Yoon
name: Lim, Woochang
Publisher: name: arXiv
Year: 2015
Subjects: subject: Neurons and Cognition (q-bio.NC)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: We consider a directed Barabási-Albert scale-free network model with symmetric preferential attachment with the same in- and out-degrees, and study emergence of sparsely synchronized rhythms for a fixed attachment degree in an inhibitory population of fast spiking Izhikevich interneurons. For a study on the fast sparsely synchronized rhythms, we fix $J$ (synaptic inhibition strength) at a sufficiently large value, and investigate the population states by increasing $D$ (noise intensity). For small $D$, full synchronization with the same population-rhythm frequency $f_p$ and mean firing rate (MFR) $f_i$ of individual neurons occurs, while for sufficiently large $D$ partial synchronization with $f_p > {\langle f_i \rangle}$ ($\langle f_i \rangle$: ensemble-averaged MFR) appears due to intermittent discharge of individual neurons; particularly, the case of $f_p > 4 {\langle f_i \rangle}$ is referred to as sparse synchronization. Only for the partial and sparse synchronization, MFRs and contributions of individual neuronal dynamics to population synchronization change depending on their degrees, unlike the case of full synchronization. Consequently, dynamics of individual neurons reveal the inhomogeneous network structure for the case of partial and sparse synchronization, which is in contrast to the case of statistically homogeneous random graphs and small-world networks. Finally, we investigate the effect of network architecture on sparse synchronization in the following three cases: (1) variation in the degree of symmetric attachment (2) asymmetric preferential attachment of new nodes with different in- and out-degrees (3) preferential attachment between pre-existing nodes (without addition of new nodes). In these three cases, both relation between network topology and sparse synchronization and contributions of individual dynamics to the sparse synchronization are discussed.
description: 54 pages, 13 figures. arXiv admin note: text overlap with arXiv:1403.1034
title: Brain perfusion techniques a comparison analysis
Creators: name: Soto García, Marta
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Image verification
subject: Blood
subject: Technical aspects
subject: Diagnostic procedure
subject: Contrast agent-intravenous
subject: MR
subject: Radiographers
subject: Neuroradiology brain

description: Aims and objectives Methods and materials Results Conclusion Personal information References
description: Aims and objectives: MRI perfusion studies (MRIP) give access to information on the capillary microcirculation of brain tissue. The main quantitative parameters measured are blood volume and temporal data (transit time, time to contrast peak…) 1 .The growth of...
MTORC1 promotes T-bet phosphorylation to regulate Th1 differentiation
Creators: name: Haile, A.
name: Banerjee, A.
name: Gamper, C.J.
name: Arwood, M.L.
name: Hagan, R.S.
name: Chornoguz, O.
name: Powell, J.D.
Publisher: name: American Association of Immunologists
Year: 2017

description: CD4+ T cells lacking the mTORC1 activator Rheb fail to secrete IFN-g under Th1 polarizing conditions. We hypothesized that this phenotype is due to defects in regulation of the canonical Th1 transcription factor T-bet at the level of protein phosphorylation downstream of mTORC1. To test this hypothesis, we employed targeted mass-spectrometry proteomic analysis-multiple reaction monitoring mass spectrometry. We used this method to detect and quantify predicted phosphopeptides derived from T-bet. By analyzing activated murine wild-type and Rheb-deficient CD4+ T cells, as well as murine CD4+ T cells activated in the presence of rapamycin, a pharmacologic inhibitor of mTORC1, we were able to identify six T-bet phosphorylation sites. Five of these are novel, and four sites are consistently dephosphorylated in both Rheb-deficient CD4+ T cells and T cells treated with rapamycin, suggesting mTORC1 signaling controls their phosphorylation. Alanine mutagenesis of each of the six phosphorylation sites was tested for the ability to impair IFN-g expression. Single phosphorylation site mutants still support induction of IFN-g expression; however, simultaneous mutation of three of the mTORC1-dependent sites results in significantly reduced IFN-g expression. The reduced activity of the triple mutant T-bet is associated with its failure to recruit chromatin remodeling complexes to the Ifng gene promoter. These results establish a novel mechanism by which mTORC1 regulates Th1 differentiation, through control of T-bet phosphorylation.
Some identities involving polynomial coefficients
Creators: name: Fahssi, Nour-Eddine
Publisher: name: arXiv
Year: 2015
Subjects: subject: Number Theory (math.NT)
subject: Combinatorics (math.CO)
subject: FOS: Mathematics
subject: 11B65, 05A10, 05A19

description: By polynomial (or extended binomial) coefficients, we mean the coefficients in the expansion of integral powers, positive and negative, of the polynomial $1+t +\cdots +t^{m}$; $m\geq 1$ being a fixed integer. We will establish several identities and summation formulæ parallel to those of the usual binomial coefficients.
description: 13 pages
(101749) Bertram Edward Sheppard
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Playing Hide and Seek: Review and Hidden Areas on Chest X-ray for the Trainee
Creators: name: Mizzi, Adrian
Publisher: name: European Congress of Radiology
Year: 2017
Subjects: subject: Neoplasia
subject: Education and training
subject: Perception image
subject: Education
subject: Digital radiography
subject: CT
subject: Respiratory system
subject: Anatomy

description: Learning objectives Background Findings and procedure details Conclusion Personal information References
description: Learning objectives: To demonstrateimportant review areas on frontal chest radiograph, where serious pathology may easilybe...
Hyaluronan fragments induce IFNβ via a novel TLR4-TRIF-TBK1-IRF3- dependent pathway
Creators: name: Collins, S.L.
name: Chan-Li, Y.
name: Hamblin, M.J.
name: Black, K.E.
name: Powell, J.D.
name: Hagan, R.S.
name: Horton, M.R.
name: Hallowell, R.W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Background: The extracellular matrix plays a critical role in insuring tissue integrity and water homeostasis. However, breakdown products of the extracellular matrix have emerged as endogenous danger signals, designed to rapidly activate the immune system against a potential pathogen breach. Type I interferons play a critical role in the immune response against viral infections. In the lungs, hylauronan (HA) exists as a high molecular weight, biologically inert extracellular matrix component that is critical for maintaining lung function. When lung tissue is injured, HA is broken down into lower molecular weight fragments that alert the immune system to the breach in tissue integrity by activating innate immune responses. HA fragments are known to induce inflammatory gene expression via TLR-MyD88-dependent pathways. Methods. Primary peritoneal macrophages from C57BL/6 wild type, TLR4 null, TLR3 null, MyD88 null, and TRIF null mice as well as alveolar and peritoneal macrophage cell lines were stimulated with HA fragments and cytokine production was assessed by rt-PCR and ELISA. Western blot analysis for IRF3 was preformed on cell lysates from macrophages stimulate with HA fragments. Results: We demonstrate for the first time that IFNβ is induced in murine macrophages by HA fragments. We also show that HA fragments induce IFNβ using a novel pathway independent of MyD88 but dependent on TLR4 via TRIF and IRF-3. Conclusions: Overall our findings reveal a novel signaling pathway by which hyaluronan can modulate inflammation and demonstrate the ability of hyaluronan fragments to induce the expression of type I interferons in response to tissue injury even in the absence of viral infection. This is independent of the pathway of the TLR2-MyD88 used by these matrix fragments to induce inflammatory chemokines. Thus, LMW HA may be modifying the inflammatory milieu simultaneously via several pathways.
p31 comet acts to ensure timely spindle checkpoint silencing subsequent to kinetochore attachment
Creators: name: Hagan, R.S.
name: Shah, J.V.
name: Manak, M.S.
name: Meier, M.G.
name: Buch, H.K.
name: Sorger, P.K.
name: Meraldi, P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: The spindle assembly checkpoint links the onset of anaphase to completion of chromosome-microtubule attachment and is mediated by the binding of Mad and Bub proteins to kinetochores of unattached or maloriented chromosomes. Mad2 and BubR1 traffic between kinetochores and the cytosol, thereby transmitting a "wait anaphase" signal to the anaphase-promoting complex. It is generally assumed that this signal dissipates automatically upon kinetochore-microtubule binding, but it has been shown that under conditions of nocodazole-induced arrest p31comet, a Mad2-binding protein, is required for mitotic progression. In this article we investigate the localization and function of p31 comet during normal, unperturbed mitosis in human and marsupial cells. We find that, like Mad2, p31 comet traffics on and off kinetochores and is also present in the cytosol. Cells depleted of p31 comet arrest in metaphase with mature bipolar kinetochore-microtubule attachments, a satisfied checkpoint, and high cyclin B levels. Thus p31 comet is required for timely mitotic exit. We propose that p31 comet is an essential component of the machinery that silences the checkpoint during each cell cycle.