cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Synthesis and evaluation of in vitro and in vivo anti-Toxoplasma gondii activity of tetraoxane-substituted ursolic acid derivatives
Creators: name: Wang, Ya-Lan
name: Jin, Li-Li
name: Cheng, Xu
name: Yan, Wei-Feng
name: Deng, Hao
name: Shen, Qing-Kun
name: Quan, Zhe-Shan
name: Jin, Chun-Mei
name: Zhang, Chang-Hao
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine

description: A series of derivatives of ursolic acid (UA) were synthesised, the anti-Toxoplasma gondii activity was tested, and the selectivity index (SI) of these compounds was calculated to determine the derivative with the best anti-Toxoplasma gondii activity. Compound A7 showed the best activity against the Toxoplasma gondii (IC50 in T. gondii infected GES-1 cells: 9.1 ± 7.2 μM), better than the lead compound UA and the positive control drug Spiramycin. Compound A7 was selected for further in vivo research: A7 was tested for its effect on the inhibition rate of tachyzoites in mice and its biochemical parameters, such as alanine aminotransferase, aspartate aminotransferase, glutathione, and malondialdehyde were determined. Compound A7 was evaluated for its anti-Toxoplasma activity and partial damage to the liver. Therefore, the results show that compound A7 could be a potential lead compound for developing a novel anti-Toxoplasma gondii molecule.
The substantia nigra pars reticulata in vitro and in silico
Creators: name: Thompson, William Scott
name: Hjorth, Johannes
name: Kozlov, Alexander
name: Silberberg, Gilad
name: Hellgren Kotaleski, Jeanette
name: Grillner, Sten
Publisher: name: Zenodo
Year: 2023

description: Presentation at SfN 2022, San Diego, CA. Program No. 272.08.
Studiare gli attori
Creators: name: Ferrone, Siro
Publisher: name: Drammaturgia
Year: 2014

description: This essay lays the foundation for methodological criteria to study the history of actors for a longer span of time. Starting from the Ancient Regime centuries, where the contribution of actors to the drama invention is more decipherable, to nowadays, where documents overload risks to hide the contribution of players to the building of a collective work, a critical interpretation of sources is necessary to rebuild actors biographies and to restore their fundamental point of view. Il saggio pone i criteri metodologici fondativi per lo studio della storia degli attori all'interno di un periodo di lunga durata. A partire dai secoli di Antico regime, dove più decifrabile è l'apporto degli interpreti all'invenzione drammaturgica, fino ai giorni nostri, dove l'eccesso di documenti rischia di nascondere il contributo dei recitanti alla costruzione di un'opera collettiva, si impone una lettura critica delle fonti per ricostruire le biografie degli attori e restaurarne il fondamentale punto di vista.
description: Drammaturgia, Vol 11 No 1 (2014): Anno XI / n.s. I – 2014
title: Auf dem Weg zu krisenfesten  Vielfaltsstrategien?
title: Erfolgsfaktoren und Herausforderungen  kommunaler Integrationspolitik
titleType: Subtitle
Creators: name: Gesemann, Frank
name: Freudenberg, Lea
name: Walther, Claudia
Publisher: name: Bertelsmann Stiftung
Year: 2023
Subjects: Integrationspolitik
Kommune
Migration
Integration

description: In dieser Ausgabe von Analysen und Konzepte beschäftigen wir uns mit den Entwicklungen kommunaler Integrationspolitik der letzten zwei Jahrzehnte. Hintergrund sind die aktuellen Herausforderungen sowie eine zukünftig benötigte höhere Resilienz. Eine Vielzahl von Krisen und Ereignissen der vergangenen Jahre hat einen spürbaren Effekt auf deutsche Kommunen entwickelt.
Il lavoro dell’attrice. Interpreti, capocomiche e imprenditrici italiane dal XVIII alla prima metà del XX secolo
Creators: name: Agostini, Emanuela
Publisher: name: Drammaturgia
Year: 2014

description: The article describes the research project The Work of the Actress. Players and Actress-Managers from the 18th century to the mid 20th century submitted under call for proposals FIRB 2012. L'articolo illustra il progetto di ricerca Il lavoro dell’attrice. Interpreti, capocomiche e imprenditrici dal XVIII secolo alla prima metà del XX secolo presentato al bando di finanziamento Firb 2012.
description: Drammaturgia, Vol 11 No 1 (2014): Anno XI / n.s. I – 2014
Making complex interventions work in low resource settings: developing and applying a design focused implementation approach to deliver mental health through primary care in India
Creators: name: Ramaswamy, Rohit
Publisher: name: BioMed Central
Year: 2018

description: Abstract Background Globally, there is a large treatment gap for people with mental disorders, and this gap is especially extreme in Low and Middle Income Countries. This gap can be potentially bridged by integrating evidenced based mental health interventions into primary care, but there is little knowledge about how to do this well, especially in countries with weak health systems. Research into the best implementation approaches is a priority, but in order to do so, it is first necessary to adapt implementation science principles and tools for mental health services in low resource settings. Results The frameworks that have been used to implement evidence-based behavioral health and health care interventions in High Income Countries do not directly apply to contexts where resources and processes for service delivery and support do not exist. We propose an implementation approach for low resource settings, called design-focused implementation, emphasizing the design of delivery systems using systematic design methods as precursor to implementation in severely resource constrained environments. This approach draws from existing literature in design thinking, quality implementation, improvement science and evaluation and we describe its use in creating the processes, organizations and the enabling environment for integration of mental health service delivery into primary care in India. Conclusions Design-focused implementation will be useful for guiding research and practice in closing the implementation gap for a wide variety of complex interventions in low resource settings.
Baghdad City in Poetry: Fabled Metropolis Valorized and Elegized
Creators: name: Al-Shamali, Farah
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 470206
subject: Cultural studies of nation and region
classificationCode: 470514
subject: Literary theory
classificationCode: 360201
subject: Creative writing (incl. scriptwriting)
classificationCode: 439999
subject: Other history, heritage and archaeology not elsewhere classified

description: Amongst the return to ruin ravaging Baghdad, its poets lamented the fall from utopian bliss to dystopia with their words representing a pained spatiality and reckoning with character-altering devastation. There is a love of place as it suffers human vices, one of the complexities of representation. Within these poeticisms are numerous historiographies. Earlier poets such as Muti ibn Iyas and Abd Allah ibn Al-Mubarak capture the urban majesty igniting the imagination. Yet it inspired contradictory emotions. Time ensured that, as destruction defined space, the poet crossed the threshold in the subject-object interaction. Those like Sa'di Shirazi, elegizing the ghostly capital after the 1258 Mongol invasion, was broken himself with his rhythmic cadence reflecting a hemorrhaging mentality. When violence invades the poetics of creation, some like Abdulghani Al-Jamil strip language of an embellished exterior. It is a desire to resist. Woundedness speaks back to the city uncovering a spatiality of loss.
Low-energy tetrahedral polymorphs of carbon, silicon, and germanium
Creators: name: Mujica, Andres
name: Pickard, Chris J.
name: Needs, Richard J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: Searches for low-energy tetrahedral polymorphs of carbon and silicon have been performed using density functional theory computations and the ab initio random structure searching (AIRSS) ap- proach. Several of the hypothetical phases obtained in our searches have enthalpies that are lower or comparable to those of other polymorphs of group 14 elements that have either been experimentally synthesized or recently proposed as the structure of unknown phases obtained in experiments, and should thus be considered as particularly interesting candidates. A structure of P bam symmetry with 24 atoms in the unit cell was found to be a low energy, low-density metastable polymorph in carbon, silicon, and germanium. In silicon, Pbam is found to have a direct band gap at the zone center with an estimated value of 1.4 eV, which suggests applications as a photovoltaic material. We have also found a low-energy chiral framework structure of P 41 21 2 symmetry with 20 atoms per cell containing fivefold spirals of atoms, whose projected topology is that of the so-called Cairo-type two- dimensional pentagonal tiling. We suggest that P41 21 2 is a likely candidate for the structure of the unknown phase XIII of silicon. We discuss Pbam and P41 21 2 in detail, contrasting their energetics and structures with those of other group 14 elements, particularly the recently proposed P42 /ncm structure, for which we also provide a detailed interpretation as a network of tilted diamond-like tetrahedra.
Introduction to supercomputers and PRACE: What are supercomputers, why do we need them, how they are used?
Creators: name: Povh, Janez
name: Kos, Leon
Publisher: name: Zenodo
Year: 2021
Subjects: HPC
PRACE
NoMachine
Training Material

description: Introduction to supercomputers and PRACE: What are supercomputers, why do we need them, how they are used? Introducing the participants to modern hardware, HPCs, PRACE project What is a shared memory computer? The concept architecture and real hardware. Using HPC-FS and NoMachine desktop
Two truxinate derivatives and a phenyldilactone from the leaves of Castanopsis eyrei
Creators: name: Wang, Ya-feng
name: Pang, Nao
name: Liang, Zhen-hua
name: Huang, Yong-lin
name: He, Rui-jie
name: Yang, Bing-yuan
name: Liu, Zhang-bin
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biophysics
Biochemistry
Pharmacology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Virology
Computational Biology

description: Phytochemical investigation of the Leaves of Castanopsis eyrei led to the isolation of two new natural truxinate derivatives and a new phenyldilactone. The structures of the new natural compounds were determined by spectroscopic methods and chemical evidence as 3,3',4,4'-tetrahydroxy-β-truxillic acid (1), 3,3',4,4'-tetrahydroxy-δ-truxillic acid (2), 3'-hydroxymaysedilactone A (3). Establishment of a Caenorhabditis elegans lipid metabolism model using GFP and mCherry fluorescently labeled lipid droplets to screen compound 3 for its activity in reducing lipid accumulation.
Simplifying Wireless Social Caching
Creators: name: Karmoose, Mohammed
name: Cardone, Martina
name: Fragouli, Christina
Publisher: name: arXiv
Year: 2016
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: Social groups give the opportunity for a new form of caching. In this paper, we investigate how a social group of users can jointly optimize bandwidth usage, by each caching parts of the data demand, and then opportunistically share these parts among themselves upon meeting. We formulate this problem as a Linear Program (LP) with exponential complexity. Based on the optimal solution, we propose a simple heuristic inspired by the bipartite set-cover problem that operates in polynomial time. Furthermore, we prove a worst case gap between the heuristic and the LP solutions. Finally, we assess the performance of our algorithm using real-world mobility traces from the MIT Reality Mining project dataset and two mobility traces that were synthesized using the SWIM model. Our heuristic performs closely to the optimal in most cases, showing a better performance with respect to alternative solutions.
description: Parts of this work were accepted for publication in ISIT 2016. A complete version is submitted to Transactions on Mobile Computing
Towards Metadata Driven Harmonisation
Creators: name: Mills, Hayley
name: Johnson, Jon
Publisher: name: Zenodo
Year: 2023
Subjects: Metadata
Harmonisation
DDI
CLOSER
Longitudinal

description: Data harmonisation for longitudinal population studies (LPS) involves retrospectively adjusting data collected by different surveys to allow comparisons. Repeating the same analysis across several LPS allows researchers to test whether results are consistent, or differ due to changing or different social conditions. Finding detailed information about data for harmonisation is however resource intensive, with a high level of uncertainty about the possible success. CLOSER Discovery is a metadata research tool which enables users to discover, explore and assess data. It can help provide assurance of the quality and utility for any potential harmonisation. Information held in CLOSER Discovery such as the question text, the available responses, mode of interview and a consistent vocabulary, can be used to identify comparable data within and across LPS. CLOSER aims to enhance the metadata further by adding variable concordance, enabling direct comparison of variables within and across LPS. The purpose is to save researchers’ time by providing sufficient information to make decisions about whether the data are suitable for their harmonisation use case. This task is a large undertaking not only in scale, with CLOSER Discovery containing 11 LPS, but poses a significant challenge in how to align variables within a consistent conceptual framework. This presentation will set out our approach in identifying variables across surveys and how this will be structured to be useful for Discovery users. It will detail the main considerations for determining a workable conceptual framework and we would value input as to whether this is the ideal approach for us and its utility to the research user community.
An upper limit for macromolecular crowding effects
Creators: name: Li, Conggang
name: Pielak, Gary J.
name: Miklos, Andrew C
Publisher: name: BioMed Central Ltd
Year: 2011

description: Abstract: Background: Solutions containing high macromolecule concentrations are predicted to affect a number of protein properties compared to those properties in dilute solution. In cells, these macromolecular crowders have a large range of sizes and can occupy 30% or more of the available volume. We chose to study the stability and ps-ns internal dynamics of a globular protein whose radius is ~2 nm when crowded by a synthetic microgel composed of poly(N-isopropylacrylamide-co-acrylic acid) with particle radii of ~300 nm. Results: Our studies revealed no change in protein rotational or ps-ns backbone dynamics and only mild (~0.5 kcal/mol at 37°C, pH 5.4) stabilization at a volume occupancy of 70%, which approaches the occupancy of closely packing spheres. The lack of change in rotational dynamics indicates the absence of strong crowder-protein interactions. Conclusions: Our observations are explained by the large size discrepancy between the protein and crowders and by the internal structure of the microgels, which provide interstitial spaces and internal pores where the protein can exist in a dilute solution-like environment. In summary, microgels that interact weakly with proteins do not strongly influence protein dynamics or stability because these large microgels constitute an upper size limit on crowding effects.
Competing Hydrostatic Compression Mechanisms in Nickel Cyanide
Creators: name: Adamson, Jasper
name: Lucas, Timothy C.
name: Cairns, Andrew B.
name: Funnell, Nicholas P.
name: Tucker, Matthew G.
name: Kleppe, Annette K.
name: Hriljac, Joseph A.
name: Goodwin, Andrew L.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We use variable-pressure neutron and X-ray diffraction measurements to determine the uniaxial and bulk compressibilities of nickel(II) cyanide, Ni(CN)$_2$. Whereas other layered molecular framework materials are known to exhibit negative area compressibility, we find that Ni(CN)$_2$ does not. We attribute this difference to the existence of low-energy in-plane tilt modes that provide a pressure-activated mechanism for layer contraction. The experimental bulk modulus we measure is about four times lower than that reported elsewhere on the basis of density functional theory methods [{\it Phys. Rev. B} {\bf 83}, 024301 (2011)].
description: 6 pages, 5 figures, 1 table
Effective tools and best practices for live online tutorials: ready-to-run virtual environments with AiiDA and Quantum Mobil
Creators: name: Bercx, Marnick
Publisher: name: Zenodo
Year: 2021
Subjects: HPC
virtual environments
AiiDA
Quantum Mobil
Training Material

description: Effective tools and best practices for live online tutorials: ready-to-run virtual environments with AiiDA and Quantum Mobil
The Shifted Convolution of Divisor Functions
Creators: name: Topacogullari, Berke
Publisher: name: arXiv
Year: 2015
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11N37 (Primary), 11F30, 11N75 (Secondary)

description: We prove an asymptotic formula for the shifted convolution of the divisor functions $d_3(n)$ and $d(n)$, which is uniform in the shift parameter and which has a power-saving error term. The method is also applied to give analogous estimates for the shifted convolution of $d_3(n)$ and Fourier coefficents of holomorphic cusp forms. These asymptotics improve previous results obtained by several different authors.
Vitamin D receptor expression controls proliferation of naïve CD8+ T cells and development of CD8 mediated gastrointestinal inflammation
Creators: name: Bruce, Danny
name: Chen, Jing
name: Cantorna, Margherita T
Publisher: name: BioMed Central Ltd
Year: 2014

description: Abstract Background Vitamin D receptor (VDR) deficiency contributes to the development of experimental inflammatory bowel disease (IBD) in several different models. T cells have been shown to express the VDR, and T cells are targets of vitamin D. In this article we determined the effects of VDR expression on CD8+ T cells. Results VDR KO CD8+ T cells, but not WT CD8+ T cells, induced colitis in Rag KO recipients. In addition, co-transfer of VDR KO CD8+ T cells with naïve CD4+ T cells accelerated colitis development. The more severe colitis was associated with rapidly proliferating naïve VDR KO CD8+ T cells and increased IFN-γ and IL-17 in the gut. VDR KO CD8+ T cells proliferated in vitro without antigen stimulation and did not downregulate CD62L and upregulate CD44 markers following proliferation that normally occurred in WT CD8+ T cells. The increased proliferation of VDR KO CD8+ cells was due in part to the higher production and response of the VDR KO cells to IL-2. Conclusions Our data indicate that expression of the VDR is required to prevent replication of quiescent CD8+ T cells. The inability to signal through the VDR resulted in the generation of pathogenic CD8+ T cells from rapidly proliferating cells that contributed to the development of IBD.
APPC 2020 Mask Study
Creators: name: Pasek, Josh
name: Dias, Nic
name: Holbert, Lance
name: Hardy, Bruce
name: Levendusky, Matt
name: Winneg, Kenneth
name: Jamieson, Kathleen
name: Romer, Daniel
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Communication
subject: Political Science
subject: FOS: Political science
subject: Social and Behavioral Sciences

description: Experimental study on excess recruits to APPC election study designed to test impacts of mask and bible image messaging.
Garcicowanones C-E, three new hydrated-geranylated xanthones from the roots of Garcinia cowa Roxb. ex Choisy, and their α-glucosidase inhibition activities
Creators: name: An, Nguyen Thi Kim
name: Van Hien, Nguyen
name: Thuy, Nguyen Thi
name: Phuong, Doan Lan
name: Bach, Ha Gia
name: Tra, Nguyen Thanh
name: Tung, Nguyen Quang
name: Tham, Pham Thi
name: Tai, Bui Huu
name: Thuy, Tran Thi Thu
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biochemistry
Space Science
Medicine
Pharmacology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Developmental Biology

description: Three new xanthones, garcicowanones C-E (1 − 3), and six known xanthones (4 − 9) were isolated from the roots of Garcinia cowa Roxb. ex Choisy. Their chemical structures were determined using spectroscopic technics, including HR-ESI-MS and 2 D NMR. All isolated compounds were evaluated for in vitro α-glucosidase inhibition. Cowanol (6) and norcowanin (8) had the most potent α-glucosidase inhibitory activity, with respective IC50 values of 33.5 ± 0.8 and 17.2 ± 0.3 µM, compared with the positive control, acarbose (IC50 257.3 ± 4.8 µM).
Variáveis Modificáveis que Impactam sobre a Progressão da Osteoartrite de Joelho e Quadril
Creators: name: Montenegro, Renata
name: COSTA, GILKA
name: Alves, Karoline
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Medicine and Health Sciences

description: Trata-se de uma revisão de escopo, estruturada pelo Joanna Briggs Institute (JBI).
Novel opportunities for sub-meV inelastic X-ray scattering at high-repetition rate self-seeded X-ray free-electron lasers
Creators: name: Chubar, Oleg
name: Geloni, Gianluca
name: Kocharyan, Vitali
name: Madsen, Anders
name: Saldin, Evgeni
name: Serkez, Svitozar
name: Shvyd'ko, Yuri
name: Sutter, John
Publisher: name: arXiv
Year: 2015
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Inelastic X-ray scattering (IXS) is an important tool for studies of equilibrium dynamics in condensed matter. A new spectrometer recently proposed for ultra-high-resolution IXS (UHRIX) has achieved 0.6~meV and 0.25~nm$^{-1}$ spectral and momentum transfer resolutions, respectively. However, further improvements down to 0.1~meV and 0.02~nm$^{-1}$ are required to close the gap in energy-momentum space between high and low frequency probes. We show that this goal can be achieved by further optimizing the X-ray optics and by increasing the spectral flux of the incident X-ray pulses. UHRIX performs best at energies from 5 to 10 keV, where a combination of self-seeding and undulator tapering at the SASE-2 beamline of the European XFEL promises up to a hundred-fold increase in average spectral flux compared with nominal SASE pulses at saturation, or three orders of magnitude more than possible with storage-ring based radiation sources. Wave-optics propagation shows that about $7\times 10^{12}$~ph/s in a $90$-$μ$eV bandwidth can be achieved on the sample. This will provide unique new possibilities for dynamics studies by IXS.
description: 17 pages, 14 figures
A comprehensive system for evaluation of remote sequence similarity detection
Creators: name: Qi, Yuan
Publisher: name: BioMed Central Ltd
Year: 2007

description: Abstract Background Accurate and sensitive performance evaluation is crucial for both effective development of better structure prediction methods based on sequence similarity, and for the comparative analysis of existing methods. Up to date, there has been no satisfactory comprehensive evaluation method that (i) is based on a large and statistically unbiased set of proteins with clearly defined relationships; and (ii) covers all performance aspects of sequence-based structure predictors, such as sensitivity and specificity, alignment accuracy and coverage, and structure template quality. Results With the aim of designing such a method, we (i) select a statistically balanced set of divergent protein domains from SCOP, and define similarity relationships for the majority of these domains by complementing the best of information available in SCOP with a rigorous SVM-based algorithm; and (ii) develop protocols for the assessment of similarity detection and alignment quality from several complementary perspectives. The evaluation of similarity detection is based on ROC-like curves and includes several complementary approaches to the definition of true/false positives. Reference-dependent approaches use the 'gold standard' of pre-defined domain relationships and structure-based alignments. Reference-independent approaches assess the quality of structural match predicted by the sequence alignment, with respect to the whole domain length (global mode) or to the aligned region only (local mode). Similarly, the evaluation of alignment quality includes several reference-dependent and -independent measures, in global and local modes. As an illustration, we use our benchmark to compare the performance of several methods for the detection of remote sequence similarities, and show that different aspects of evaluation reveal different properties of the evaluated methods, highlighting their advantages, weaknesses, and potential for further development. Conclusion The presented benchmark provides a new tool for a statistically unbiased assessment of methods for remote sequence similarity detection, from various complementary perspectives. This tool should be useful both for users choosing the best method for a given purpose, and for developers designing new, more powerful methods. The benchmark set, reference alignments, and evaluation codes can be downloaded from ftp://iole.swmed.edu/pub/evaluation/.
Dynamical Mass Ejection from Binary Neutron Star Mergers
Creators: name: Radice, David
name: Galeazzi, Filippo
name: Lippuner, Jonas
name: Roberts, Luke F.
name: Ott, Christian D.
name: Rezzolla, Luciano
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We present fully general-relativistic simulations of binary neutron star mergers with a temperature and composition dependent nuclear equation of state. We study the dynamical mass ejection from both quasi-circular and dynamical-capture eccentric mergers. We systematically vary the level of our treatment of the microphysics to isolate the effects of neutrino cooling and heating and we compute the nucleosynthetic yields of the ejecta. We find that eccentric binaries can eject significantly more material than quasi-circular binaries and generate bright infrared and radio emission. In all our simulations the outflow is composed of a combination of tidally- and shock-driven ejecta, mostly distributed over a broad $\sim 60^\circ$ angle from the orbital plane, and, to a lesser extent, by thermally driven winds at high latitudes. Ejecta from eccentric mergers are typically more neutron rich than those of quasi-circular mergers. We find neutrino cooling and heating to affect, quantitatively and qualitatively, composition, morphology, and total mass of the outflows. This is also reflected in the infrared and radio signatures of the binary. The final nucleosynthetic yields of the ejecta are robust and insensitive to input physics or merger type in the regions of the second and third r-process peaks. The yields for elements on the first peak vary between our simulations, but none of our models is able to explain the Solar abundances of first-peak elements without invoking additional first-peak contributions from either neutrino and viscously-driven winds operating on longer timescales after the mergers, or from core-collapse supernovae.
description: 19 pages, 10 figures. We corrected a problem in the formulation of the neutrino heating scheme and re-ran all of the affected models. The main conclusions are unchanged. This version also contains one more figure and a number of improvements on the text
Introduction to PETSc
Creators: name: Lecas, Dimitri
name: Lacroix, Remi
name: Van Criekingen, Serge
Publisher: name: Zenodo
Year: 2021
Subjects: HPC
PETSc
Training Material

description: The Portable, Extensible Toolkit for Scientific Computation (PETSc) is a suite of data structures and routines for the scalable (parallel) solution of scientific applications modeled by partial differential equations (www.mcs.anl.gov/petsc/). It enables researchers to delegate the linear algebra part of their applications to a specialized team, and to test various solution methods. The course will provide the necessary basis to get started with PETSc and give an overview of its possibilities. Presentations will alternate with hands-on sessions (in C or Fortran). Learning outcomes : On completion of this course, the participant should
 - Be able to build and solve simple PDE examples
 - Use and compare different solvers on these examples
 - Be familiar with using the on-line documentation
 - Be able to easily explore other PETsc possibilities relevant to his/her application. Prerequisites : C or Fortran programming.
 Notions of linear algebra, as well as notions of MPI, would be an asset.
Synthesis and evaluation of in vitro and in vivo anti-Toxoplasma gondii activity of tetraoxane-substituted ursolic acid derivatives
Creators: name: Wang, Ya-Lan
name: Jin, Li-Li
name: Cheng, Xu
name: Yan, Wei-Feng
name: Deng, Hao
name: Shen, Qing-Kun
name: Quan, Zhe-Shan
name: Jin, Chun-Mei
name: Zhang, Chang-Hao
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine

description: A series of derivatives of ursolic acid (UA) were synthesised, the anti-Toxoplasma gondii activity was tested, and the selectivity index (SI) of these compounds was calculated to determine the derivative with the best anti-Toxoplasma gondii activity. Compound A7 showed the best activity against the Toxoplasma gondii (IC50 in T. gondii infected GES-1 cells: 9.1 ± 7.2 μM), better than the lead compound UA and the positive control drug Spiramycin. Compound A7 was selected for further in vivo research: A7 was tested for its effect on the inhibition rate of tachyzoites in mice and its biochemical parameters, such as alanine aminotransferase, aspartate aminotransferase, glutathione, and malondialdehyde were determined. Compound A7 was evaluated for its anti-Toxoplasma activity and partial damage to the liver. Therefore, the results show that compound A7 could be a potential lead compound for developing a novel anti-Toxoplasma gondii molecule.
Ardisia blatteri Gamble 1921
Creators: name: Roy, Rijupalika
name: Roy, Anirban
name: Pramanik, Arabinda
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Ericales
Primulaceae
Ardisia
Ardisia blatteri

description: Ardisia blatteri Gamble (1921: 121)
 Lectotype (designated here): — INDIA. High Wavy Mountain, 4000–5000 ft, May 1917, Blatter & Hallberg 564 (K barcode K000756696 [digital photo!], arrow; isolectotype CAL 279223!), Fig. 1.
 Notes:— Gamble (1921) cited in the protologue five gatherings from South India: “ Blatter & Hallberg 3, 251, 552, 564 and T.F. Bourdillon 14”. The gatherings of “Blatter & Hallberg” are from Madura district (in a mountainous area near Cumbum) and that of “T.F. Bourdillon” is from Hills of Travancore in moist forest of Tamil Nadu.
 According to Stafleu & Cowan (1976) the Gamble’s herbarium is kept at K and duplicates are at B, BM, CAL, DD, H, L, OXF and US. We traced relevant specimens at CAL, K and MH that can be considered as original material (Art. 9.3 of the ICN, McNeill et al. 2012).
 The specimen “ T.F. Bourdillon 14 ” kept in MH (barcode MH00002292) consists of two twigs mounted on the same sheet, but it is doubtfully included by Gamble (1921) in the protologue of A. blatteri and cited as “ T.F. Bourdillon 14 is probably the same species, but the leaf-nervation is less conspicuous”. The specimen “ Blatter & Hallberg 552 ” kept in K (barcode K000756695) fits the protologue, but has only a single flower with the calyx and gynoecium. The specimens in K “ Blatter & Hallberg 564 ” (barcode K000756696) and “ Blatter & Hallberg 251 ” (barcode K000756697) are mounted on the same sheet. The specimen “ Blatter & Hallberg 564 ” is on right side along with dissected floral parts and sketches on a piece of paper. The specimen “ Blatter & Hallberg 251” (barcode K000756697) is on the left side with a packet including a leaf and fruits pasted at right corner of the sheet. The specimen “ Blatter & Hallberg 564” housed at CAL (No. 279223) has flowers, and fits the protologue. Finally, We were not able to trace the specimen “ Blatter & Hallberg 3” in the consulted herbaria.
 The specimen “ Blatter & Hallberg 564” kept in K (barcode K000756696) clearly depicts the diagnostic characters of A. blatteri and perfectly fits the protologue, therefore, is designated here as lectotype (Arts. 9.2, 9.11 and 9.12 of the ICN, McNeill et al., 2012).
 Additional specimens examined (syntypes):— INDIA. High Wavy Mountain, 4000–5000 ft, May 1917, Blatter & Hallberg 251 (K barcode K000756697 [digital photo!]); Madura, Cumbum, High Wavy Mountain, 4000–5000 ft, May 1917, Blatter & Hallberg 552 (K barcode 000756695 [digital photo!]); Travancore, 2000–4000 ft, February 1887, T. F. Bourdillon 14 (MH barcode MH00002292!).
description: Published as part of Roy, Rijupalika, Roy, Anirban & Pramanik, Arabinda, 2017, Typification of Ardisia blatteri (Primulaceae), pp. 92-94 in Phytotaxa 295 (1) on page 92, DOI: 10.11646/phytotaxa.295.1.10, http://zenodo.org/record/13695546
Supplemental materials for preprint: Data Protection Record of Processing Activities and Privacy Notice generator toolkit by EMBL’s European Bioinformatics Institute
Creators: name: Gonzalez-Ferreiro, Montserrat
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Business
subject: Engineering
subject: Law
subject: FOS: Law
subject: Data protection
subject: GDPR
subject: intergovernmental organisations
subject: personal data
subject: privacy notice
subject: record of processing activities
subject: research infrastructures

description: Templates for the Data Protection Record of Processing Activities and Privacy Notice generator toolkit by EMBL’s European Bioinformatics Institute.
Stellar oscillations - the adiabatic case
Creators: name: Mosser, Benoit
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: This lecture on adiabatic oscillations is intended to present the basis of asteroseismology and to serve as an introduction for other lectures of the EES 2014. It also exposes the state-of-the-art of solar-like oscillation analysis, as revealed by the space missions CoRoT and Kepler. A large part of the lecture is devoted to the interpretation of the modes with a mixed character that reveal the properties of the radiative cores of subgiants and red giants.
description: 103 pages
Error estimates of finite element method for semi-linear stochastic strongly damped wave equation
Creators: name: Qi, Ruisheng
name: Wang, Xiaojie
Publisher: name: arXiv
Year: 2015
Subjects: subject: Numerical Analysis (math.NA)
subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60H35, 60H15, 65C30

description: In this paper, we consider a semi-linear stochastic strongly damped wave equation driven by additive Gaussian noise. Following a semigroup framework, we establish existence, uniqueness and space-time regularity of a mild solution to such equation. Unlike the usual stochastic wave equation without damping, the underlying problem with space-time white noise (Q = I) allows for a mild solution with a positive order of regularity in multiple spatial dimensions. Further, we analyze a spatio-temporal discretization of the problem, performed by a standard finite element method in space and a well-known linear implicit Euler scheme in time. The analysis of the approximation error forces us to significantly enrich existing error estimates of semidiscrete and fully discrete finite element methods for the corresponding linear deterministic equation. The main results show optimal convergence rates in the sense that the orders of convergence in space and in time coincide with the orders of the spatial and temporal regularity of the mild solution, respectively. Numerical examples are finally included to confirm our theoretical findings.
description: 27 pages, 2 figures
HIV-1 infection, response to treatment and establishment of viral latency in a novel humanized T cell-only mouse (TOM) model
Creators: name: Garcia, J. Victor
name: Wahl, Angela
name: Archin, Nancie M
name: Margolis, David
name: Honeycutt, Jenna B
name: Choudhary, Shailesh
Publisher: name: BioMed Central Ltd
Year: 2013

description: Abstract Background The major targets of HIV infection in humans are CD4+ T cells. CD4+ T cell depletion is a hallmark of AIDS. Previously, the SCID-hu thy/liv model was used to study the effect of HIV on thymopoeisis in vivo. However, these mice did not develop high levels of peripheral T cell reconstitution and required invasive surgery for infection and analysis. Here, we describe a novel variant of this model in which thy/liv implantation results in systemic reconstitution with human T cells in the absence of any other human hematopoietic lineages. Results NOD/SCID-hu thy/liv and NSG-hu thy/liv mice were created by implanting human fetal thymus and liver tissues under the kidney capsule of either NOD/SCID or NSG mice. In contrast to NOD/SCID-hu thy/liv mice that show little or no human cells in peripheral blood or tissues, substantial systemic human reconstitution occurs in NSG-hu thy/liv. These mice are exclusively reconstituted with human T cells (i.e. T-cell only mice or TOM). Despite substantial levels of human T cells no signs of graft-versus-host disease (GVHD) were noted in these mice over a period of 14 months. TOM are readily infected after parenteral exposure to HIV-1. HIV replication is sustained in peripheral blood at high levels and results in modest reduction of CD4+ T cells. HIV-1 replication in TOM responds to daily administration of combination antiretroviral therapy (ART) resulting in strong suppression of virus replication as determined by undetectable viral load in plasma. Latently HIV infected resting CD4+ T cells can be isolated from suppressed mice that can be induced to express HIV ex-vivo upon activation demonstrating the establishment of latency in vivo. Conclusions NSG-hu thy/liv mice are systemically reconstituted with human T cells. No other human lymphoid lineages are present in these mice (i.e. monocytes/macrophages, B cells and DC are all absent). These T cell only mice do not develop GVHD, are susceptible to HIV-1 infection and can efficiently maintain virus replication. HIV infected TOM undergoing ART harbor latently infected, resting CD4+ T cells.
Longitudinal, cross-cohort comparison of physical activity patterns in Chinese mothers and children
Creators: name: Gordon-Larsen, Penny
name: Popkin, Barry
name: Dearth-Wesley, Tracy
name: Adair, Linda
Publisher: name: BioMed Central Ltd
Year: 2012

description: AbstractBackgroundThere is limited evidence comparing adult and child physical activity (PA) trends and examining parent–child PA associations within a newly industrialized country setting. PA research within a newly industrialized country setting is particularly important given the negative effects of rapid urbanization, socioeconomic growth, and technological advances on PA behaviors. The purpose of our study was to examine trends and associations in PA behaviors in Chinese mother-child pairs and to investigate relationships between PA behaviors and socioeconomic variables in this dyad.MethodsWe studied PA behaviors in 2 separate cohorts of mother-child pairs (n = 353) followed over a 2–4 year time period using longitudinal data from the China Health and Nutrition Survey (2000 Cohort: 2000–2004; 2004 Cohort: 2004–2006). Comparable mother-child PA behaviors included total metabolic equivalent hours per week (MET-hrs/wk) from active commuting, leisure-time sports, and sedentary behaviors. Logistic regression models were used to examine associations between mother and child PA and relationships between PA behaviors and socioeconomic variables.ResultsChildren experienced increases in active commuting and leisure-time sports activities with increasing child age, whereas mothers experienced temporal declines in active commuting and minimal change in leisure-time sports activity. Sedentary behavior was high for children and mothers over time. Mother-child associations were positive for active commuting and leisure-time sports activities and negative for sedentary behavior (P < 0.05). Maternal education was associated with a greater likelihood of high leisure-time sports activity and high sedentary behavior in mothers but not in children (P < 0.05).ConclusionEfforts to reduce sedentary behavior in Chinese mothers and children are imperative. While increased leisure-time and active commuting activities in children is encouraging, continued PA promotion in children and more intensive efforts to promote leisure-time sports and active commuting in mothers is needed.
title: Quoi, mon genre te dérange ?
title: Quoi, mon genre te dérange ?
titleType: AlternativeTitle
Creators: name: Donnet-Monay, Jocelyne
Publisher: name: Unknown
Year: 0
Subjects: subject: Identité
subject: Genre
subject: Trans*
subject: Inclusion scolaire
subject: Diversité
subject: Socialisation

description: Ce travail de recherche cible principalement les jeunes trans et non binaires et comment celles·ceux-ci sont accompagné·es en milieu scolaire. Il a pour finalité d’identifier les freins et leviers qui entrent ou interfèrent dans les processus de socialisation et d’inclusion scolaire de ceux·celles-ci. Il est mené au prisme d’une perspective historique et de valeurs personnelles et institutionnelles, mises à l’épreuve face au changement de paradigme du genre. Cette minorité non binaire représenterait entre 1,2 et 2,7 % de la population (Fondation Agnodice, 2022). Un plus grand groupe, rassemblant toutes les expressions de genre atypiques, représenterait par contre, selon certaines études et les critères mis en évidence, entre 6 % et 38,6 % de la population (Sandberg, cité dans Diversité sexuelle et de genre, 2017 ; Teychenné, 2013). Dans le contexte d'une école qui se projette comme inclusive, on est en droit de se demander comment celle-ci accueille cette diversité de genre dans les faits et dans le quotidien de la vie de la classe. Plusieurs intervenant·es se demandent même jusqu’où admettre tant de diversités sans niveler les objectifs (Maulini, 2000) ou avoir l’impression de donner des avantages (annexe 2, l. 463-465 ; Rouyer et al., 2014). Pour répondre à ces questions, deux axes de recherches ont été retenus. La première étape a consisté à réaliser une revue de la littérature scientifique pour nous appuyer sur des bases théoriques. Par ailleurs, nous avons situé le contexte scolaire, identifié les prescriptions et cadres légaux en vigueur. Ces éléments ont mis en évidence que le milieu scolaire devait faire face à un dilemme éthique de précaution discriminante et se trouvait en étau entre investissement et ingérence. La deuxième étape est celle de la confrontation de ces données théoriques à la réalité, en considérant l’apport de trois témoignages de terrain (émotionnel, technique, pratique). Il en ressort que l’égalité reste un concept théorique ne correspondant pas toujours au besoin d’équité révélé par la pratique (annexe 2, l. 483-483). Cette étape débouche sur la mise en évidence des freins et leviers de la mise en œuvre d’une inclusion de cette minorité. Le travail propose enfin de (re)définir des pistes plus universelles pour mieux vivre et comprendre « l’Autre » (Abdallah-Pretceille, 2008) et éviter l’isolement social.
Wreath product of matrices
Creators: name: D'Angeli, Daniele
name: Donno, Alfredo
Publisher: name: arXiv
Year: 2015
Subjects: subject: Rings and Algebras (math.RA)
subject: FOS: Mathematics
subject: 15A69, 15A18, 05C50, 05C76, 05C81

description: We introduce a new matrix product, that we call the wreath product of matrices. The name is inspired by the analogous product for graphs, and the following important correspondence is proven: the wreath product of the adjacency matrices of two graphs provides the adjacency matrix of the wreath product of the graphs. This correspondence is exploited in order to study the spectral properties of the famous Lamplighter random walk: the spectrum is explicitly determined for the "Walk or switch" model on a complete graph of any size, with two lamp colors. The investigation of the spectrum of the matrix wreath product is actually developed for the more general case where the second factor is a circulant matrix. Finally, an application to the study of generalized Sylvester matrix equations is treated.
description: 25 pages
Self-similar transmission properties of aperiodic Cantor potentials in gapped graphene
Creators: name: Rodríguez-González, R.
name: Rodríguez-Vargas, I.
name: Díaz-Guerrero, D. S.
name: Gaggero-Sager, L. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: We investigate the transmission properties of quasiperiodic or aperiodic structures based on graphene arranged according to the Cantor sequence. In particular, we have found self-similar behaviour in the transmission spectra, and most importantly, we have calculated the scalability of the spectra. To do this, we implement and propose scaling rules for each one of the fundamental parameters: generation number, height of the barriers and length of the system. With this in mind we have been able to reproduce the reference transmission spectrum, applying the appropriate scaling rule, by means of the scaled transmission spectrum. These scaling rules are valid for both normal and oblique incidence, and as far as we can see the basic ingredients to obtain self-similar characteristics are: relativistic Dirac electrons, a self-similar structure and the non-conservation of the pseudo-spin. This constitutes a reduction of the number of conditions needed to observe self-similarity in graphene-based structures, see Díaz-Guerrero et al. [D. S. Díaz-Guerrero, L. M. Gaggero-Sager, I. Rodríguez-Vargas, and G. G. Naumis, arXiv:1503.03412v1, 2015].