cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Multi-version execution for increasing the reliability and availability of updated software
Creators: name: Hosek, Petr
Publisher: name: Imperial College London
Year: 2015

description: Software updates are an integral part of the software development and maintenance process, but unfortunately they present a high risk, as new releases often introduce new bugs and security vulnerabilities; as a consequence, many users refuse to upgrade their software, relying instead on outdated versions, which often leave them exposed to known software bugs and security vulnerabilities. In this thesis we propose a novel multi-version execution approach, a variant of N-version execution, for improving the software update process. Whenever a new program update becomes available, instead of upgrading the software to the newest version, we run the new version in parallel with the old one, and carefully synchronise their execution to create a more reliable multi-version application. We propose two different schemes for implementing the multi-version execution technique—via failure recovery and via transparent failover—and we describe two possible designs for implementing these schemes: Mx, focused on recovering from crashes caused by the faulty software updates; and Varan, focused on running a large number of versions in parallel with a minimal performance overhead. Mx uses static binary analysis, system call interposition, lightweight checkpointing and runtime state manipulation to implement a novel fault recovery mechanism, which enables the recovery of the crashing version using the code of the other, non-crashing version. We have shown how Mx can be applied successfully to recover from real crashes in several real applications. Varan combines selective binary rewriting with high-performance event streaming to significantly reduce performance overhead, without sacrificing the size of the trusted computing base, nor flexibility or ease of debugging. Our experimental evaluation has demonstrated that Varan can run C10k network servers with low performance overhead, and can be used in various scenarios such as transparent failover and live sanitisation.
How to tell the shape of a wormhole by its quasinormal modes
Creators: name: Konoplya, R. A.
Publisher: name: arXiv
Year: 2018
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Here we shall show how to reconstruct the shape function of a spherically symmetric traversable Lorenzian wormhole near its throat if one knows high frequency quasinormal modes of the wormhole. The wormhole spacetime is given by the Morris-Thorne ansatz. The solution to the inverse problem via fitting of the parameters within the WKB approach is unique for arbitrary tideless wormholes and some wormholes with non-zero tidal effects, but this is not so for arbitrary wormholes. As examples, we reproduce the near throat geometries of the Bronnikov-Ellis and tideless Morris-Thorne metrics by their quasinormal modes at high multipole numbers $\ell$.
description: 8 pages, revtex4, 1 figure; version accepted for publication in Physics Letters B
A dimensionally split Cartesian cut cell method for the compressible Navier-Stokes equations
Creators: name: Gokhale, Nandan
name: Nikiforakis, Nikos
name: Klein, Rupert
Publisher: name: arXiv
Year: 2018
Subjects: subject: Computational Physics (physics.comp-ph)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: We present a dimensionally split method for computing solutions to the compressible Navier-Stokes equations on Cartesian cut cell meshes. The method is globally second order accurate in the L1 norm, fully conservative, and allows the use of time steps determined by the regular grid spacing. We provide a description of the three-dimensional implementation of the method and evaluate its numerical performance by computing solutions to a number of test problems ranging from the nearly incompressible to the highly compressible flow regimes. All the computed results show good agreement with reference results from theory, experiment and previous numerical studies. To the best of our knowledge, this is the first presentation of a dimensionally split cut cell method for the compressible Navier-Stokes equations in the literature.
Isolating Red Giant Stars in M31's Elusive Outer Spheroid
Creators: name: Reitzel, David B.
name: Guhathakurta, Puragra
name: Gould, Andrew
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Deep UBRI images of a 15'x15' field in the M31 galaxy's outer spheroid obtained with the KPNO 4-m telescope, and Keck 10-m telescope+LRIS I-band images, are used to isolate candidate red giant branch stars located at R=19 kpc (projected) along the minor axis. These stars are distinguished from the more numerous distant field galaxies by isolating objects whose colors are consistent with the long but narrow locus occupied by RGB stars in UBRI color space and whose angular sizes are consistent with the stellar PSF (FWHM~0.6"-1.5"). We carry out the same analysis of data on a comparison field with a similar Galactic latitude to the M31 halo field. The color-magnitude diagram of comparison field objects is well described by a superposition of foreground Galactic dwarf stars against a backdrop of faint blue field galaxies, while the M31 halo field contains a clear excess of faint red objects (I~20-23, B-I~2-3.5) in addition to these two components. The CMD location of this population of faint red objects is as would be expected for RGB stars at the distance of M31. The surface density of RGB candidates in the R=19 kpc M31 halo field is consistent with the findings of two recent HST studies. The data indicate that M31's stellar halo is much denser/larger than that of the Galaxy: (ρ_M31/ρ_MW) (Λ/1.5)^(-ν) ~ 10, where Λis the ratio of M31's and the Galaxy's radial scale lengths and ν=-3.8 is the assumed power law index of the density profile. The color and slope of the RGB in M31's outer halo are suggestive of a relatively metal-rich population, [Fe/H] >~ -1, in agreement with the HST measurements.
description: 39 pages, 8 figures and 2 tables. Full resolution figures available at: http://www.ucolick.org/~reitzel/
Removal of phosphate from wastewater by Fe-C micro-electrolysis: application of a novel integrated Fe/C aggregate
Creators: name: Shao, Yutian
name: Bai, Yang
name: Liu, Mingwei
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Physiology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Computational Biology

description: To overcome the drawbacks of typical Fe-C micro-electrolysis in wastewater treatment, we developed a new electrolysis material, integrated Fe/C aggregate (FCA) made from Fe0 and carbon powder, and used it for phosphate removal from wastewater. Results show that the free iron ions could quickly react with PO43- and form an iron phosphate precipitate in phosphate-containing wastewater. The release rate of iron ions was extremely rapid in the first 10 h, indicating that Fe-C microscopic galvanic cells formed on the aggregate surface. Acid conditions are beneficial for accelerating the Fe-C micro-electrolysis reaction and enhancing the iron ion release capacity and phosphate removal capacity. In batch experiments, the maximum phosphate removal capacity of FCA was found to be 10.84 mg P/g. The phosphate removal behavior of FCA can be well described by the Langmuir isotherm model and the pseudo-second-order kinetic model. SEM and XPS investigations also revealed that phosphates were absorbed by ferrous or ferric hydroxide and generated Fe-P precipitate, which adhered to the surface of FCA throughout the phosphate removal process. Because of its low cost and outstanding performance, the FCA aggregate has a high potential for P removal in wastewater treatment.
HST Images of a Galaxy Group at z=2.81, and the Sizes of Damped Lyman Alpha Galaxies
Creators: name: Moller, Palle
name: Warren, Stephen J.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: We present HST WFPC2 observations in three bands (F450W, F467M and F814W) of a group of three galaxies at z=2.8 discovered in a ground-based narrow-band search for Lyman alpha emission near the z=2.8 quasar PKS0528-250. One of the galaxies is a damped (DLA) absorber and these observations bear on the relation between the DLA clouds and the Lyman-break galaxies and the stage in the evolution of galaxies they represent. We describe a procedure for combining the undersampled WFPC2 images pointed on a sub-pixel grid, which largely recovers the full sampling of the WFPC2 point spread function (psf). These three galaxies have similar properties to the Lyman-break galaxies except that they have strong Lyman alpha emission. The three galaxies are detected in all three bands, with average B~26, I~25. Two of the galaxies are compact with intrinsic (i.e. after correcting for the effect of the psf) half-light radii of ~0.1 arcsec (~0.4/h kpc, q_o=0.5). The third galaxy comprises two similarly compact components separated by 0.3 arcsec. The HST images and a new ground-based Lyman alpha image of the field provide evidence that the three galaxies are more extended in the light of Lyman alpha than in the continuum. The measured impact parameters for this DLA galaxy (1.17 arcsec), for a second confirmed system, and for several candidates, provide a preliminary estimate of the cross-section-weighted mean radius of the DLA gas clouds at z~3 of less than 13/h kpc, for q_o=0.5. Given the observed sky covering factor of the absorbers this implies that for q_o=0.5 the space density of DLA clouds at these redshifts is more than five times the space density of spiral galaxies locally, with the actual ratio probably considerably greater. For q_o=0.0 there is no evidence as yet that DLA clouds are more common than spiral galaxies locally.
description: 11 pages, LaTeX, 6 Figures total (4 colour GIF-format, 2 PostScript), accepted for publication in MNRAS
X-ray tomography of extended objects: a comparison of data acquisition approaches
Creators: name: Du, Ming
name: Vescovi, Rafael
name: Fezzaa, Kamel
name: Jacobsen, Chris
name: Gursoy, Doga
Publisher: name: arXiv
Year: 2018
Subjects: subject: Image and Video Processing (eess.IV)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: The penetration power of x-rays allows one to image large objects. For example, centimeter-sized specimens can be imaged with micron-level resolution using synchrotron sources. In this case, however, the limited beam diameter and detector size preclude the acquisition of the full sample in a single take, necessitating strategies for combining data from multiple regions. Object stitching involves the combination of local tomography data from overlapping regions, while projection stitching involves the collection of projections at multiple offset positions from the rotation axis followed by data merging and reconstruction. We compare these two approaches in terms of radiation dose applied to the specimen, and reconstructed image quality. Object stitching involves an easier data alignment problem, and immediate viewing of subregions before the entire dataset has been acquired. Projection stitching is more dose-efficient, and avoids certain artifacts of local tomography; however, it also involves a more difficult data assembly and alignment procedure, in that it is more sensitive to accumulative registration error.
description: Under review
H-alpha Objective Prism Survey of Abell 1060
Creators: name: Bennett, S. M.
name: Moss, C.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: As part of a continuing study of the effect of cluster environment on the star formation properties of galaxies, we have undertaken an H-alpha objective prism survey of the nearby cluster, Abell 1060. We detect 33 galaxies in emission, 24 of which are cluster members. We present new radial velocity measurements and H-alpha+[NII] equivalent widths and fluxes for a number of these galaxies. We distinguish between galaxies with diffuse and compact emission, the latter having been associated in previous work with a disturbed morphology of the galaxy and most likely resulting from tidally-induced star formation from galaxy-galaxy or cluster-galaxy interactions. The fraction of cluster spirals in Abell 1060 detected with compact emission agrees with the expected fraction for a cluster of its richness, as derived from results of a previous survey of 8 clusters. Some of the detected cluster early-type spirals exhibit anomalously high global H-alpha equivalent widths, as compared to galaxies of similar type in the field.
description: 10 pages, Latex, 2 figures, needs l-aa macros. Accepted for publication in Astronomy and Astrophysics Supplement Series
Additional file 2: of Estimation of the diaphragm neuromuscular efficiency index in mechanically ventilated critically ill patients
Creators: name: Jansen, Diana
name: Jonkman, Annemijn
name: Roesthuis, Lisanne
name: Suvarna Gadgil
name: Hoeven, Johannes Van Der
name: Gert-Jan Scheffer
name: Girbes, Armand
name: Doorduin, Jonne
name: Sinderby, Christer
name: Heunks, Leo
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Marine Biology

description: Overview of the five repeated occlusions in each individual patient. The blue line represents the EAdi signal expressed in microvolts. The orange line represents the airway pressure (Paw) expressed in cmH2O. (DOCX 1942 kb)
Penning trap and vacuum noise
Creators: name: Rosu, H. C.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: A number of comments are provided on Rogers's model experiment to measure the circular Unruh vacuum noise by means of a hyperbolic Penning trap inside a microwave cavity. It is suggested that cylindrical Penning traps, being geometrically simpler, and controlled almost at the same level of accuracy as the hyperbolic trap, might be a better choice for such an experiment. Besides, the microwave modes of the trap itself, of known analytical structure, can be directly used in trying to obtain measurable results for such a tiny noise effect.
description: 7 LaTex pages, published text and references with titles
Improving microbial chemical production strains through transcriptional regulatory network rewiring
Creators: name: Rodrigues, Rui Tiago De Lima
Publisher: name: Imperial College London
Year: 2015

description: The production of chemicals using microbes is an area of significant interest for academia and industry. Significant resources are often devoted to strain development not only for the increase of productivity and yield but also for the improvement of robustness and tolerance to industrial production conditions. The genetic regulatory network of microbial organisms has evolved to maximize growth and survival in a variety of dynamic environmental conditions found in nature. Many of these responses can be suboptimal for the purpose of industrial manufacture of valuable bioproducts. A small number of methods have been developed to explore the effect of perturbing these networks with the objective of obtaining improved strains. This thesis explores the use of transcriptional regulatory network rewiring as a general strategy for improvement of strains used in the production of chemical compounds. Libraries generated using a regulatory network rewiring strategy – addition of nodes to wildtype background – were screened for enhanced production of a target compound or other phenotypes of interest. Combinatorial libraries of promoters and coding regions of transcriptional regulators were used to test the strategy towards the improvement of phenotypical limitations of M. smegmatis (growth rate) and for the isolation of strains with improved production of lycopene in P. pastoris. The method was shown to allow for the identification of potential fast growing strains in M. smegmatis and for the isolation of strains with improved production of lycopene in P. pastoris. In the lycopene project, a strain was isolated that was shown to produce significantly higher levels of lycopene in suboptimal aeration conditions as well as modest improvements in non-limited cultures, providing a hint that the strategy could be applied for the development of strains with large phenotypical diversity, and towards the understanding of complex factors limiting production of compounds of interest.
Introduction to Quantum Optics
Creators: name: Man'ko, V. I.
Publisher: name: arXiv
Year: 1995
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The theory of quantum propagator and time--dependent integrals of motion in quantum optics is reviewed as well as the properties of Wigner function, Q--function, and coherent state representation. Propagators and wave functions of a free particle, harmonic oscillator, and the oscillator with varying frequency are studied using time--dependent linear in position and momentum integrals of motion. Such nonclassical states of light (of quantum systems) as squeezed states, correlated states, even and odd coherent states (Schrödinger cat states) are considered. Photon distribution functions of Schrödinger cat male and female states are given, and the photon distribution function of squeezed vacuum is derived using the theory of the oscillator with varying parameters. Properties of multivariable Hermite polynomials used for the description of the multimode squeezed and correlated light and polymode Schrödinger cats are studied.
description: Latex,35 pages,Lectures in Latin America Scool of Physics 1995
Understanding the structure/property/processing inter-relationships in organic semiconducting blends
Creators: name: Westacott, Paul
Publisher: name: Imperial College London
Year: 2014

description: Over the last few years organic semiconductors have seen a dramatic rise in interest from both academia and industry alike. This has been largely due to their promise of low-cost, high-throughput manufacture, combined with many other positive attributes including their: flexibility; semi-transparency and light-weight nature. This combination of factors show that organic semiconductors hold strong potential to compete with inorganic technologies in a number of existing and emerging applications. More specifically, blends comprised of a number organic semiconductors offer significant promise for devices such as organic photovoltaics (OPVs) and organic light emitting diodes (OLEDs), as tuning the chemical nature of the constituting materials can influence the blend’s optoelectronic properties. However, during processing, such as blending, complex mixture of phases are formed which renders understanding these systems challenging. This thesis examines the relationships between the three critical aspects that affect organic semiconducting blends, namely: the processing route selected, the resulting microstructure and, as a consequence, the induced optoelectronic properties. A more comprehensive understanding is developed of how the processing route (solution casting from common solvent vs. bilayer fabrication via lamination) can affect the structural formation processes in organic semiconductor systems, such as crystallisation, vitrification etc. Additionally, this thesis elucidates how the structural formation processes influence the mixture of phases that evolve and discusses how the microstructure that is created affects the photo-physical processes such as exciton quenching and charge generation, within these systems. The results within this thesis highlight the sensitive interplay between the three areas of structure, property and processing. Clear insights into how to manipulate these aspects to positively impact the photo-physical processes are conferred. The findings discussed here give, thus, clear guidelines as to how to further enhance understanding and terminally improve the performance of devices such as organic solar cells.
Neutrino Mass Ordering from Oscillations and Beyond: 2018 Status and Future Prospects
Creators: name: de Salas, P. F.
name: Gariazzo, S.
name: Mena, O.
name: Ternes, C. A.
name: Tórtola, M.
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The ordering of the neutrino masses is a crucial input for a deep understanding of flavor physics, and its determination may provide the key to establish the relationship among the lepton masses and mixings and their analogous properties in the quark sector. The extraction of the neutrino mass ordering is a data-driven field expected to evolve very rapidly in the next decade. In this review, we both analyze the present status and describe the physics of subsequent prospects. Firstly, the different current available tools to measure the neutrino mass ordering are described. Namely, reactor, long-baseline (accelerator and atmospheric) neutrino beams, laboratory searches for beta and neutrinoless double beta decays and observations of the cosmic background radiation and the large scale structure of the universe are carefully reviewed. Secondly, the results from an up-to-date comprehensive global fit are reported: the Bayesian analysis to the 2018 publicly available oscillation and cosmological data sets provides \emph{strong} evidence for the normal neutrino mass ordering versus the inverted scenario, with a significance of 3.5 standard deviations. This preference for the normal neutrino mass ordering is mostly due to neutrino oscillation measurements. Finally, we shall also emphasize the future perspectives for unveiling the neutrino mass ordering. In this regard, apart from describing the expectations from the aforementioned probes, we also focus on those arising from alternative and novel methods, as 21~cm cosmology, core-collapse supernova neutrinos and the direct detection of relic neutrinos.
description: 62 pages, 3 Tables and 15 figures. Invited Review for the 'Frontiers in Astronomy and Space Science' - Section 'High Energy and Astroparticle Physics', Research Topic 'From the Fermi Scale to Cosmology'. v2 matches the version accepted for publication
Additional file 1 of Human amniotic stem cells-derived exosmal miR-181a-5p and miR-199a inhibit melanogenesis and promote melanosome degradation in skin hyperpigmentation, respectively
Creators: name: Wang, Xiao-Yu
name: Guan, Xiao-Hui
name: Yu, Zhen-Ping
name: Wu, Jie
name: Huang, Qi-Ming
name: Deng, Ke-Yu
name: Xin, Hong-Bo
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: Hematology

description: Additional file 1. Figure S1. The identification of hASCs and the effect of their CM on the proliferation and migration of B16F10. Figure S2. Exosomes derived from hAESCs inhibited hyperpigmentation. Figure S3. Bioinformatics analysis of hAMSCs-derived exosomes. Figure S4. Quantitative analysis is shown in Western blotting. Table S1. The sequences of Real-Time PCR primers. Table S2. miRNAs expression in top from hAMSCs-secreted exosomes.
title: Frühe literale Praktiken
Creators: name: Cordeiro, Glaís
name: Isler, Dieter
name: Thévenaz-Christen, Thérèse
Publisher: name: Publikationsserver der Pädagogischen Hochschule Thurgau
Year: 2011

description: Schweizerische Zeitschrift für Bildungswissenschaften, vol. 33, no. 1, p. 17
ECG Heartbeat Classification: A Deep Transferable Representation
Creators: name: Kachuee, Mohammad
name: Fazeli, Shayan
name: Sarrafzadeh, Majid
Publisher: name: arXiv
Year: 2018
Subjects: subject: Computers and Society (cs.CY)
subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: Electrocardiogram (ECG) can be reliably used as a measure to monitor the functionality of the cardiovascular system. Recently, there has been a great attention towards accurate categorization of heartbeats. While there are many commonalities between different ECG conditions, the focus of most studies has been classifying a set of conditions on a dataset annotated for that task rather than learning and employing a transferable knowledge between different tasks. In this paper, we propose a method based on deep convolutional neural networks for the classification of heartbeats which is able to accurately classify five different arrhythmias in accordance with the AAMI EC57 standard. Furthermore, we suggest a method for transferring the knowledge acquired on this task to the myocardial infarction (MI) classification task. We evaluated the proposed method on PhysionNet's MIT-BIH and PTB Diagnostics datasets. According to the results, the suggested method is able to make predictions with the average accuracies of 93.4% and 95.9% on arrhythmia classification and MI classification, respectively.
Engineering protein cages with synthetic biology
Creators: name: Field, James Edward John
Publisher: name: Imperial College London
Year: 2014

description: Nanotechnology has the potential to revolutionise every facet of human life. One particularly exciting branch of nanotechnology involves the construction of nanodevices using protein cages. Protein cages are spherically shaped structures with large internal cavities. The research described in this thesis was conducted with the aim of rationalising the design and fabrication of protein cage-based nanodevices. Protein-based nanodevices are typically constructed by re-engineering naturally occurring protein chassis (e.g. ferritin). To rationalise the process of chassis selection, an online registry of protein cages, rings and tubes was designed and populated by computationally mining the Protein Data Bank. The resulting registry was made publically available to the research community through the website – www.nanodevice.build. The functionality of protein cage-based nanodevices can be augmented by packaging inorganic nanoparticles inside their internal cavities. The methods currently used to achieve this typically involve exposure to harsh conditions, which can cause irreversible damage to the protein cage. To address this, a strategy for efficiently packaging inorganic nanoparticles into protein cages under mild conditions was formulated and tested. These experiments were conducted using gold nanoparticles and a number of different protein cages (e.g. Bfr, FtnH and FtnL). Cholangiocarcinoma (CCA) is a deadly liver cancer for which current treatment options are limited. Therefore a CCA-targeting protein cage-based nanodevice was designed, constructed and experimentally evaluated. CCA-targeting was achieved in the context of the CCA cell line TFK-1 using an anti-mesothelin antibody as a targeting agent. Collectively, these three outputs provide a rational framework for selecting a protein cage chassis, loading it with a pre-fabricated inorganic nanoparticle and targeting the resulting device to a particular cell-type. It is hoped that by leveraging these three tools, synthetic biologists will be able to engineer a new generation of nanodevices.
Comment on 'Reduced System Dynamics from the N-Body Schrodinger Equation'
Creators: name: Diosi, Lajos
Publisher: name: arXiv
Year: 1995
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We argue that the "reduced wave function", proposed recently [Phys.Rev.Lett. {\bf 75}, 2255 (1995)], contains conditional and restricted information on the reduced system. The concept of "reduced wave function" can thus not represent a relevant alternative to the common reduced dynamics methods.
description: 3pp LateX
$χ_{\textrm{top}}(T \gg T_{\textrm{c}})$ in pure-glue QCD through reweighting
Creators: name: Jahn, P. Thomas
name: Moore, Guy D.
name: Robaina, Daniel
Publisher: name: arXiv
Year: 2018
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We calculate the topological susceptibility at 2.5 Tc and 4.1 Tc in SU(3) pure Yang-Mills theory. We define topology with the help of gradient flow and we largely overcome the problem of poor statistics at high temperatures by applying a reweighting technique in terms of the topological charge, measured after a specific small amount of gradient flow. This allows us to obtain a sample of configurations which compares topological sectors with good statistics, with enhanced tunneling between topologies. We quote continuum extrapolated results at these two temperatures and conclude that our method is viable and can be extended without new conceptual problems to the case of full QCD with fermions.
description: 11 pages including 7 figures. Replaced with the published version
TV_PIES cruise,Alis R/V
Creators: name: GASSIER David
Publisher: name: Sismer
Year: 2014

description: L'objectif principal de la mission était de récupérer le PIES à la station 1 et d'y déployer un équipement identique. Un objectif secondaire était la récupération des données acquises par le mouillage subsurface de la station2 (en acoustique uniquement).
Bixasteroid, a new compound from the fruits of Bixa orellana and its anti-inflammatory activity
Creators: name: Chen, Yi-min
name: Xu, Tian-qi
name: Zhang, Xiao-qi
name: Fan, Chun-lin
name: Ye, Wen-cai
name: Xu, Wei
name: Zhou, Guang-xiong
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Bixasteroid (1), one new steroid together with five known compounds (2–6), were isolated from the ethyl acetate fraction of ethanol extract of Bixa orellana fruits. All of these known compounds were isolated from the plant for the first time. Their structures were elucidated on the basis of spectroscopic analysis, and the absolute configuration of compound 1 was determined by X-ray crystallographic data analysis as well as by the quantum chemical ECD calculations. All the isolated compounds were tested for their anti-inflammatory activities. Compounds 1 and 2 showed inhibiting NO release activities in LPS-induced RAW 264.7 macrophages with the IC50 values of 4.72 ± 0.28 and 5.48 ± 1.48 μM, respectively.
MOESM2 of Deep analysis of immune response and metabolic signature in children with food protein induced enterocolitis to cow’s milk
Creators: name: Adel-Patient, Karine
name: Lezmi, Guillaume
name: Castelli, Florence
name: Blanc, Sibylle
name: Bernard, Hervé
name: Soulaines, Pascale
name: Dumond, Pascale
name: Ah-Leung, Sandrine
name: Lageix, Florence
name: Boissieu, Delphine
name: Cortes-Perez, Naima
name: Hazebrouck, Stéphane
name: Fenaille, François
name: Junot, Christophe
name: Dupont, Christophe
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 2. Analysis of memory cells within PBMC before and after reactivation using PHA mitogen
Anti-oxidised low density lipoprotein antibodies for the serology and imaging of atherosclerosis
Creators: name: Khamis, Ramzi Yousef Jabra
Publisher: name: Imperial College London
Year: 2014

description: Atherosclerosis and its related major adverse cardiovascular events represent a major worldwide morbidity and mortality burden. The paradigm of identifying ‘vulnerable plaques’ leading to ‘vulnerable patients’ remains challenging despite recent advances in cardiovascular medicine. The project aimed to develop an antibody-based strategy for the translational development of imaging oxidised low density lipoprotein (LDL), a major constituent of vulnerable atherosclerotic plaque. It also aimed to simultaneously develop anti-oxidised LDL antibody-based serological assays for the stratification of individual cardiovascular risk independently of classical risk factors. In this thesis, I first discuss the development of a number of assays for the measurement of anti-oxidised LDL antibodies in serum and plasma. I then describe our findings, using a subpopulation of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) to discover that IgG anti-Malondialdehyde (MDA)-LDL antibody levels are stable, independent biomarkers of freedom from adverse cardiovascular events over a 5.5 year follow up. This is followed by describing LO1 and LO9, both murine monoclonal antibodies, isolated in our laboratory, against MDA-LDL and adherent native LDL respectively. We characterise and sequence both, and take LO1 further into development as an imaging agent. I then progress to discussing the utility of directly labelled LO1 (LO1-750) as a near infra-red fluorescence (NIRF) imaging agent. We use two animal models (Ldlr-/- and rabbit atherosclerosis models), utilising three different modalities (IVIS Spectrum/ computed tomography (CT), Fluorescence molecular tomography (FMT)/CT and intravascular 2D NIRF/intravascular ultrasound (IVUS)). I further discuss the generation of a partially humanised tagged molecular construct (LO1-Fab-Cys), as a first step towards the molecular expression and humanisation of LO1 in an optimised form for targeting of oxidised LDL in humans. Moreover I detail the characterisation of LO9 by delineating in a series of experiments its allosteric epitope on adherent LDL, and describe a potential pathological role for it. We label LO9 with a NIRF agent, and show LO9 localisation in vitro and in vivo in mouse studies.
TV_ORLS cruise,L'Atalante R/V
Creators: name: VIOLLETTE Pascal
Publisher: name: Sismer
Year: 2009

description: L'objectif principal de ce transit valorisé est de rendre opérationnel le nouveau positionnement dynamique EasyDP : * trouver l'origine des défauts qui ont affecté le fonctionnement lors des essais du mois d'août ; * vérifier que les bugs détectés depuis juillet ont bien été corrigés sans apporter de perturbation secondaire ; * retrouver un fonctionnement satisfaisant pour les principaux modes qui nous intéressent (SK, HK, TKLS, TKHS) ; * établir des procédures-types d'utilisation en lien avec le bord.Des essais de mise au point du logiciel CINNA ainsi que des tests liés aux dysfonctionnements des lochs seront réalisés en temps masqué..
Analytical template for gravitational-wave echoes: signal characterization and prospects of detection with current and future interferometers
Creators: name: Testa, Adriano
name: Pani, Paolo
Publisher: name: arXiv
Year: 2018
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Gravitational-wave echoes in the post-merger ringdown phase are under intense scrutiny as probes of near-horizon quantum structures and as signatures of exotic states of matter in ultracompact stars. We present an analytical template that describes the ringdown and the echo signal for nonspinning objects in terms of two physical parameters: the reflectivity and the redshift at the surface of the object. We characterize the properties of the template and adopt it in a preliminary parameter estimation with current (aLIGO) and future (Cosmic Explorer, Einstein Telescope, LISA) gravitational-wave detectors. For fixed signal-to-noise ratio in the post-merger phase, the constraints on the model parameters depend only mildly on the details of the detector sensitivity curve, but depend strongly on the reflectivity. Our analysis suggests that it might be possible to detect or rule out Planckian corrections at the horizon scale for perfectly-reflecting ultracompact objects at $5σ$ confidence level with Advanced LIGO/Virgo. On the other hand, signal-to-noise ratios in the ringdown phase equal to $\approx 100$ (as achievable with future interferometers) might allow us to probe near-horizon quantum structures with reflectivity $\gtrsim30\%$ ($\gtrsim85\%$) at $2σ$ ($3σ$) level.
description: v3: 13+4 pages, 11 figures, 4 appendices; matches the PRD version with a new plot and extended results. v2 (submitted version): 12 pages + 4 appendices; 9 figures. Further discussion and new appendix with template for localized sources at generic position. Template and waveforms available at https://www.darkgra.org/gw-echo-catalogue.html
Neurodevelopmental outcomes of children born preterm: analyses into the validity of data collection and outcome reports
Creators: name: Wong, Sze Ying
Publisher: name: Imperial College London
Year: 2015

description: Background and aims: Information on the neurodevelopmental outcomes of children born very preterm is required for multiple purposes. Reliable and up-to-date data sources are lacking. The overall aim of this thesis is to evaluate the validity and usability of the neurodevelopmental outcome data of very preterm children available from current data sources. The specific objectives were: 1) to examine the validity of outcome data recorded during routine follow-up assessment 2) to explore early childhood social-communication difficulties exhibited by very preterm children 3) to assess the stability over time of neurodevelopmental diagnoses made in early childhood. Methods: Three studies were conducted to meet the objectives. For studies 1 and 2, I recruited children born at <30 weeks’ gestation at 2 years corrected age (age corrected for prematurity) from 13 participating study sites. In study 1, I compared the agreement between the neurodevelopmental outcomes of 190 children recorded at their routine NHS assessments and data obtained by a research assessment using the Bayley Scales of Infant Development, 3rd edition. In study 2, the social-communication skills of 141 children were determined using the parent-completed Quantitative Checklist of Autism in Toddlers (Q-CHAT) questionnaire and compared to published results from the general population. In study 3, I conducted a systematic review and using meta-analytic methods, I calculated the pooled sensitivity and specificity of early developmental assessment in identifying school-age cognitive deficit from 24 studies. Conclusions: 1) Compared with research assessment, routine NHS follow-up assessment had a low sensitivity but high specificity for identifying children with neurodevelopmental impairment. 2) Very preterm children display greater early childhood social-communication difficulties and autistic behaviour than the general population as measured by their parents on the Q-CHAT. 3) Early neurodevelopmental assessment has high specificity but low sensitivity for identifying later school-age cognitive deficits.
Cypraea spurca Linnaeus, 1758, spec. nov.
Creators: name: Linnaeus, Carolus
Publisher: name: Laurentius Salvius
Year: 1758
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Littorinimorpha
Cypraeidae
Cypraea
Cypraea spurca

description: Cypraea spurca [spec. nov.]
C. testa submarginata lutescente luteo irrorata, lateribus fusco punctata.
Habitat in M. Mediterraneo.
Testa ovata, laevis, lutescens punctis pallidioribus aut saturatioribus confertim adspersa; margo supra crenulatus colore fusco; labium interius postice reflexo apice, quod huic proprium. Testa interdum occurrit livida immaculata diaphana, non dum dentes adepta, sed tamen magnitudine justa, unde apparet has senectam exuere. p. 728.
description: Published as part of Linnaeus, Carolus, 1758, Systema Naturae per regna tria naturae: secundum classes, ordines, genera, species, cum characteribus, differentiis, synonymis, locis, Stockholm :Laurentius Salvius on page 724, DOI: 10.5962/bhl.title.542, http://zenodo.org/record/3922206
Additional file 1 of Predicting clinical outcomes in neuroblastoma with genomic data integration
Creators: name: Ilyes Baali
name: D Alp Emre Acar
name: Tunde W. Aderinwale
name: HafezQorani, Saber
name: Kazan, Hilal
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Developmental Biology
subject: Marine Biology
subject: Cancer
subject: Science Policy

description: List of patients for which aCGH data is corrected. This text file contains the list of 32 patients for which aCGH data intensities are reversed. (TXT 191 b)
ROSAT X-ray Colors and Emission Mechanisms in Early-Type Galaxies
Creators: name: Irwin, Jimmy A.
name: Sarazin, Craig L.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The X-ray colors and X-ray-to-optical luminosity ratios (L_X/L_B) of 61 early- type galaxies observed with the ROSAT PSPC are determined. The colors indicate that the X-ray spectral properties of galaxies vary as a function of L_X/L_B. The brightest X-ray galaxies have colors consistent with thermal emission from hot gas with roughly the same metallicity of 50% solar. The spatial variation of the colors indicates that the gas temperature in these galaxies increases radially. Galaxies with medium L_X/L_B also have spectral properties consistent with emission from hot gas. If a simple one-component thermal model is assumed to describe the 0.1-2.0 keV X-ray emission in these galaxies, then one possible explanation for the progressive decrease in L_X/L_B among galaxies of this class could be the progressive decrease in metal abundance of the X-ray emitting contained by the galaxies. Galaxies with the lowest L_X/L_B values appear to be lacking a hot interstellar component. Their X-ray colors are consistent with those derived from the bulges of the spiral galaxies M31 and NGC1291. In M31 the X-ray emission is resolved into discrete sources, and is apparently due primarily to low mass X-ray binaries (LMXBs). We therefore suggest that the bulk of the X-ray emission in the faintest ellipticals is also due to LMXBs. Previously, the X-ray spectra of X-ray faint galaxies had been found to be described by a hard component which was attributed to LMXB emission, and a very soft component of unknown origin. We show that the very soft component also likely results from LMXBs, as a very soft component is seen in the X-ray spectra of the nearby LMXB Her X-1 and LMXBs in the bulge of M31. (Abridged)
description: 49 pages, 17 embedded Postscript figures, uses aaspp4.sty, Astrophysical Journal, volume 499, in press
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome V, Cart. 189 (11 H 74), 316 folios, f. 0145v
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome V, Archives départementales de la Côte-d'Or, Cart. 189 (11 H 74), 316 folios, f. 0145v, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome V, Archives départementales de la Côte-d'Or, Cart. 189 (11 H 74), 316 folios, f. 0145v, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Biomarkers of glomerular inflammation and fibrosis
Creators: name: Yu, Mei-Ching
Publisher: name: Imperial College London
Year: 2014

description: Progression of glomerular diseases to chronic kidney disease or renal failure is a major diagnostic and therapeutic problem. In addition to finding new treatment, more reliable biomarkers, using near patient technology, are needed to improve early detection of patients at risk of progressive renal injury. To achieve this aim, two approaches were applied to study novel biomarkers of glomerular inflammation and fibrosis. Firstly, expression of specific inflammatory cytokines and growth factors, including two members of the CCN protein family which are connective tissue growth factor (CTGF)/CCN2 and nephroblastoma overexpressed gene (NOV)/CCN3, were studied in a rat model of crescentic glomerulonephritis (GN). CCN2/CTGF is now regarded as a major profibrotic growth factor of chronic renal inflammation and fibrosis. On the other hand, recently, emerging evidence suggests that CCN3/NOV acts as an endogenous negative regulator of extracellular matrix accumulation and is capable of counteracting the fibrogenic effect of CCN2/CTGF. This targeted approach may be helpful in providing a novel insight into the pathophysiological activities of these two CCN proteins involved in progressive kidney disease and development of novel therapy. With regard to Fourier transform infrared (FTIR) spectroscopy, it has been increasingly used in biomedical research but so far it has not been investigated for diagnosing and/or screening progressive kidney disease. Thus, the second approach was aimed to investigate whether FTIR technique could be employed as an unbiased method of detecting sensitive renal biomarkers. Using FTIR spectroscopy, several characteristic urinary and plasma spectral markers related to renal inflammation and chronic fibrosis were identified from the rat model of crescentic GN. In particular the urinary 1545 cm-1 spectral marker was also reliable in assessing therapeutic responses in corticosteroid-treated rats with GN and severe lupus nephritis in mice. In addition, this urinary spectral marker was translatable in assessment of crescentic GN in patients. In conclusion, analysis of specific cytokines/growth factors and FTIR spectroscopic technology are likely to improve or assist diagnosis and evaluate progression of glomerulonephritis.