cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Efficacy of Video Prompting Using Mobile Technology to Teach Employment Tasks to Individuals with Intellectual Disability
Creators: name: Walters, Sharon
name: Stierle, Jordan
name: Stockwell, Daniel
name: Carlson, Alex
name: Ryan, Joseph
Publisher: name: Journal of Inclusive Postsecondary Education
Year: 2021

description: Abstract Individuals with intellectual disability (ID) often experience a combination of both intellectual and adaptive functioning deficits which negatively impact their ability to obtain and maintain competitive employment. Fortunately, research has shown that assistive technology, and particularly video prompting, helps support employment for individuals with ID. This single case multiple probe study investigated the efficacy of a highly customizable task analysis smartphone application in assisting three young adults with ID complete common work-related office tasks. Findings indicate all three participants demonstrated very large effect size gains in completing three unique office-related tasks once provided with the Task Analysis app. Keywords: intellectual disability, assistive technology, employment, video prompting, mobile technology
description: Journal of Inclusive Postsecondary Education, Vol. 3 No. 1 (2021): Journal of Inclusive Postsecondary Education
Boletín Fármacos: Agencias Reguladoras 2024; 27(1)
Creators: name: Salud y Fármacos
name: Homedes, Nuria
name: Ugalde, Antonio
Publisher: name: Salud y Fármacos
Year: 2024
Subjects: Medicamentos
Agencias reguladoras
Regulación internacional
América Latina
FDA
EMA
Regulación de medicamentos en países de altos ingresos
Regulación de medicamentos en países de medianos y bajos ingresos
Covid
Europa y el Reino Unido
Canadá y EE UU
Ensayos clínicos
Permisos de comercialización y cambios al etiquetado/ficha técnica
Inspecciones
Comisión Federal de Comercio
FTC
Asia
Guías y normas

description: Boletín Fármacos es un boletín electrónico de la organización Salud y Fármacos (https://www.saludyfarmacos.org/) que se publica cuatro veces al año: febrero, mayo, agosto y noviembre.

El "Boletín Fármacos: Agencias Reguladoras" incluye información sobre el desempeño de las agencias reguladoras en materia de medicamentos, tanto las de países de altos ingresos como las de países de medianos y bajos ingresos.

Este documento corresponde al 2024, Vol. 27 N°1.
Surface hydrophobicity and acidity effect on alumina catalyst in catalytic methanol dehydration reaction
Creators: name: Osman, Ahmed
Publisher: name: figshare
Year: 2017
Subjects: subject: 30601 Catalysis and Mechanisms of Reactions
subject: FOS: Chemical sciences

description: AbstractBACKGROUNDMethanol to dimethyl ether (MTD) is considered one of the main routes for the production of clean bio-fuel. The effect of copper loading on the catalytic performance of different phases of alumina that formed by calcination at two different temperatures was examined for the dehydration of methanol to dimethyl ether (DME).RESULTSA range of Cu loadings of (1, 2, 4, 6, 10 and 15% Cu wt/wt) on Al2O3 calcined at 350 and 550 °C were prepared and characterized by TGA, XRD, BET, NH3-TPD, TEM, H2-TPR, SEM, EDX, XPS and DRIFT-Pyridine techniques. The prepared catalysts were used in a fixed bed reactor under reaction conditions in which the temperature ranged from 180–300 °C with weight hourly space velocity (WHSV) = 12.1 h-1. It was observed that all catalysts calcined at 550 °C (γ-Al2O3 support phase) exhibited higher activity than those calcined at 350 °C (γ-AlOOH), and this is due to the phase support change. Furthermore, the optimum Cu loading was found to be 6% Cu/γ-Al2O3 with this catalyst also showing a high degree of stability under steady state conditions and this is attributed to the enhancement in surface acidity and hydrophobicity.CONCLUSIONThe addition of copper to the support improved the catalyst properties and activity. For all the copper modified catalysts, the optimum catalyst with high degree of activity and stability was 6% copper loaded on gamma alumina. © 2017 The Authors. Journal of Chemical Technology & Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
A Facile Green Synthetic Route for the Preparation of Highly Active γ-Al2O3 from Aluminum Foil Waste
Creators: name: Osman, Ahmed
Publisher: name: figshare
Year: 2017
Subjects: subject: 30301 Chemical Characterisation of Materials
subject: FOS: Chemical sciences

description: Recycling Aluminium foil into active catalyst for bio-fuel production
D8.3 IMPACT ASSESSMENT AND EXPLOITATION INTERIM REPORT
Creators: name: Biraj Harnal
Publisher: name: Zenodo
Year: 2022
Subjects: Digital Twin, Building Information Modelling, Communication, Exploitation, Market, Sustainable, Strategy, Business Model

description: Exploitation activities are critical components of any H2020-funded project's success. The following document provides a comprehensive summary of ASHVIN's strategy, business model, targeted market, challenges, competitors, and information about the conducted with the partners to brainstorm the key exploitable results. It lays out the current market insights and specifies the various market domains ASHVIN could target by pursuing its exploitation strategy.
PhD Thesis: Characterizing Viruses Mimicry Mechanisms with Protein-Protein Interactions and Short Linear Motifs
Creators: name: Sandoval, Andrés Becerra
Publisher: name: figshare
Year: 2017
Subjects: subject: 80301 Bioinformatics Software
subject: FOS: Computer and information sciences

description: Abstract:

Viruses are obligate intracellular parasites predominant in all domains of life. Viral infections cause diseases and death to humans and edible organisms like plants and cattle. Viral short genomes encode subversion mechanisms of the host cell subsystems. These subversion mechanisms are based on virus-host protein-protein interactions.
The descent of next generation sequencing costs has spurred an exponential growth of the number of viral genomes in bioinformatic databases. In contrast, the cost of experimental high-throughput techniques for virus-host protein-protein determination is not decreasing at the same rate. Although the number of virus-host protein-protein interactions has been growing in databases too, it is still low in order to analyze viral subversion mechanisms with system biology approaches.
There is a need of computational virus-host protein-protein interaction prediction methods. However, the number of viral and host protein 3D structures is too small in order to predict virus-host protein-protein interactions with structural methods.
The prediction of virus-host protein-protein interactions has been carried out mostly with machine learning classifiers. However, the classifiers do not reveal in high-level why the interactions were inferred and are sensitive to the training set quality. For virus-host protein-protein interactions there is still not a gold standard data set for validation of interactions.
This thesis is about predicting virus-host interactions mediated by protein short linear motifs. These interactions are more predominant than virus-host domain-domain interactions and are used by several viruses. Additionally, the inference of this kind of interactions is guided by biological hypothesis like the conservation of motifs and localization of motifs in protein disordered regions.
The result of this thesis is a computational method and platform for predicting interactions between host and viral proteins mediated by linear motifs. This candidate interactions are used to study common viral attack strategies in a particular human subsystem, the protein-synthesis machinery. Nevertheless, the methods developed can be used with any subsystem like interferon and apoptosis.
Analytical linearization of aerodynamic loads in the UVLM for nonlinear aeroelastic applications
Creators: name: Hente, Christian
Publisher: name: Hannover : Institutionelles Repositorium der Leibniz Universität Hannover
Year: 2024
Subjects: subject: aerodynamic loads
subject: analytical linearization
subject: unsteady-vortex lattice method
subject: nonlinear aeroelasticity
subject: Aerodynamische Lasten
subject: Analytische Linearisierung
subject: Nichtlineare Aeroelastik
subject: Dewey Decimal Classification::500 | Naturwissenschaften::530 | Physik
subject: Dewey Decimal Classification::600 | Technik

description: This article presents the analytical linearization of aerodynamic loads (computed with the unsteady vortex-lattice method), which is formulated as tangent matrices with respect to the kinematic states of the aerodynamic grid. The loads and their linearization are then mapped to a nonlinear structural model by means of radial-basis functions allowing for a two-way strong interaction scheme. The structural model comprises geometrically exact beams formulated in a director-based total Lagrangian description, circumventing the need for rotational degrees of freedom. The structural model is spatially discretized into finite elements and temporally discretized with the help of an implicit scheme that identically preserves momenta and energy. The resulting nonlinear discrete equations are solved by applying Newton’s method, requiring calculating the Jacobians of the whole aeroelastic system. The correctness of the linearized loads is then shown by direct comparison with their numerical counterparts. In addition, we employ our strongly-coupled aeroelastic model to investigate the nonlinear static and dynamic behavior of a suspension bridge. With this approach, we successfully investigate the numerical features of the aeroelastic system under divergence and flutter conditions.
title: ADCO, Cartulaire de Cîteaux pour les possessions de Chaugey et Maison-Dieu (Fin XVe siècle), Cart. 181 (11 H 754), 165 folios, f. 0046
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2017
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire de Cîteaux pour les possessions de Chaugey et Maison-Dieu (Fin XVe siècle), Archives départementales de la Côte-d'Or, Cart. 181 (11 H 754), 165 folios, f. 0046, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour les possessions de Chaugey et Maison-Dieu (Fin XVe siècle), Archives départementales de la Côte-d'Or, Cart. 181 (11 H 754), 165 folios, f. 0046, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
title: Les routes du commerce sino-bolivien en Amérique du Sud
Creators: name: Lagarde, David
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: Chili
subject: Commerce sino-bolivien
subject: Carte
subject: Commerce
subject: Amérique du Sud
subject: Bolivie

description: Carte présentant la circulation régionale des transports de marchandises en provenance de Chine. Les marchandises arrivent au Chili, puis sont acheminées par la Bolivie vers d'autres pays d'Amérique du Sud. Cette carte illustre (p. 135) l'ouvrage "Dans les interstices de la globalisation. Les chaînes de marchandises populaires : Chine, Chili, Bolivie" par Nico Tassi, Éditions du Croquant, dans la collection Le Grand Entrepôt, 2024.
description: Carte présentant la circulation régionale des transports de marchandises en provenance de Chine. Les marchandises arrivent au Chili, puis sont acheminées par la Bolivie vers d'autres pays d'Amérique du Sud.
Review Protocol
Creators: name: Booth, Graham
Publisher: name: OSF Registries
Year: 2022

description: PCORI seeks a systematic review to assess the evidence on the effectiveness of audio-based care compared with in-person, video-based, or other usual care for managing chronic conditions among adults. The COVID-19 Public Health Emergency necessitated a shift in healthcare delivery from in-person care to telehealth-enabled care, including both video-based and audio-based care. Audio-based care may be particularly important for vulnerable patients who continue to face challenges to accessing video-based care.
Fusion of Sentinel-1A and Sentinel-2A data for land cover mapping: a case study in the lower Magdalena region, Colombia
Creators: name: Clerici, Nicola
name: Calderón, Cesar Augusto Valbuena
name: Posada, Juan Manuel
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 20199 Astronomical and Space Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: Land cover–land use (LCLU) classification tasks can take advantage of the fusion of radar and optical remote sensing data, leading generally to increase mapping accuracy. Here we propose a methodological approach to fuse information from the new European Space Agency Sentinel-1 and Sentinel-2 imagery for accurate land cover mapping of a portion of the Lower Magdalena region, Colombia. Data pre-processing was carried out using the European Space Agency’s Sentinel Application Platform and the SEN2COR toolboxes. LCLU classification was performed following an object-based and spectral classification approach, exploiting also vegetation indices. A comparison of classification performance using three commonly used classification algorithms was performed. The radar and visible-near infrared integrated dataset classified with a Support Vector Machine algorithm produce the most accurate LCLU map, showing an overall classification accuracy of 88.75%, and a Kappa coefficient of 0.86. The proposed mapping approach has the main advantages of combining the all-weather capability of the radar sensor, spectrally rich information in the visible-near infrared spectrum, with the short revisit period of both satellites. The mapping results represent an important step toward future tasks of aboveground biomass and carbon estimation in the region.
Novel microfluidic approaches for rapid point-of-care quantitation of Escherichia coli using immunoassays
Creators: name: Azevedo-Alves, Isabel
Publisher: name: Loughborough University
Year: 2019
Subjects: subject: 90499 Chemical Engineering not elsewhere classified
subject: FOS: Chemical engineering

description: There is a major clinical demand for rapid diagnostic tests capable of detecting pathogens in human samples. This is driven by an unprecedented clinical need in prescribing antibiotics more objectively and fighting antimicrobial resistance. Despite the remarkable breakthroughs, miniaturisation of such bioassays is challenging and expensive.Urinary Tract Infections are the most common bacterial infection, with Escherichia coli (E. coli) being responsible for >80% of cases, presenting concerning resistance levels to the last generation of antibiotics. Currently, diagnostics industry struggle to deliver miniaturised biosensors capable of detection and identifying bacteria at format compatible with point-of-care.This thesis presents novel experimental insights for sensitive and rapid detection of E. coli using polyclonal antibodies immobilized on the inner surface of an inexpensive 10-bore FEP-Teflon® MicroCapillary Film. Overall the results achieved allowed identification of three major challenges for miniaturisation of bacteria detection: the interrogation volume, gravity and shear stress. Coated capillaries acted as a very high affinity system, capturing up to 100% of E. coli cells, with clear evidence of immunospecificity. In addition, an opportunity to explore the ‘open’ fluidics aspect of microcapillary systems to concentrate bacteria from a large sample volume was identified and therefore speed up the detection of bacteria in clinical samples without the need for microbiological incubation. Therefore, this enabled the development of a fluorescence sandwich immunoassay capable of quantifying E. coli in buffer and synthetic urine in less than 25 minutes, yielding a limit of detection (LoD) up to 240 CFU/ml, commensurate with the cut-off value required for UTIs (103-105 CFUs/ml). This proof-of-concept was achieved exploiting low cost readout systems such as a smartphone and demonstrated reproducible and robust performance in synthetic urine. Ultimately, two new gravity-driven microfluidic devices, denominated MCF-funnel and MCF-siphon, were designed and manufactured to address autonomy, power-free and portability requirements.
Normierung und Standardisierungim Digitalen Zeitalter
Creators: name: Scherer, Peter
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2017
Subjects: BIM
VDC
IPD

description: DIe Normierung im digitalen Zeitalter des vernetzten Wissens stellt insbesondere die hoch regulierte Bau- und Immobilienbranche vor grosse Herausforderungen.
Optimierung Ausführungsplanung Holzbau durch BIM Prinzipien
Creators: name: Siegrist, Thomas
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2017
Subjects: BIM

description: Momentan schwebt die Holzbaubranche auf einer Erfolgswelle. Die Architekten und Bauherren möchten mit Holz bauen und die Vorschriften lassen Holzkonstruktionen in alle Gebäudekategorien zu. Jedoch müssen dazu die Prozesse so gestaltet werden, dass die Projekte, welche immer grösser werden, schneller und besser geplant werden können.
title: Виды художественных деталей в детско-юношеской прозе ХХ—ХХI вв.
Creators: name: Мухамадеева, Рушания
name: Божкова, Галина
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: Статья посвящена анализу наиболее частотных видов художественных деталей в литературе для детей и подростков ХХ—ХХI вв. Достижение цели осуществлялось путем реализации поставленных задач: определить преобладающие виды художественных деталей в детской прозе XX века, выявить частотные детали в современной подростковой литературе. Для получения максимально точных результатов нами были определены следующие методы исследования: структурно-семантический— при работе с видами и функциями художественной детали; культурно-исторический — при интерпретации художественных произведений и метод литературоведческого анализа текста. Материалом для анализа были выбраны 8 произведений (3 текста подростковой прозы и 5 — современной юношеской литературы). В произведениях А.И.Куприна, М.М.Пришвина и П.П.Бажова наиболее частотны такие виды художественных деталей, как пейзажные и портретные (детали-сравнения). В прозе М.С.Аромштам, Ю.Н.Кузнецовой, А.В.Соя и Ю.В.Линде преобладают предметные и портретные детали (детали-впечатления). Делается вывод о том, что действительность в последние десятилетия значительно поменялась, и современная литература призвана помогать адаптироваться ребенку во взрослой жизни, используя мягкие пути решения.
title: ADCO, Boursier de Cîteaux : comptes (1489-1493) (11 H 1166), f. 00311
Creators: name: de la Côte-d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: comptes
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Boursier de Cîteaux : comptes (1489-1493), Archives départementales de la Côte-d'Or, (11 H 1166). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Boursier de Cîteaux : comptes (1489-1493), Archives départementales de la Côte-d'Or, (11 H 1166), f. 00311, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Quantum work statistics of controlled evolutions
Creators: name: Campbell, Steve
Publisher: name: Freie Universität Berlin
Year: 2023
Subjects: subject: quantum work statistics
subject: controlled dynamics
subject: counterdiabatic driving field
subject: 500 Naturwissenschaften und Mathematik::530 Physik::530 Physik

description: We use the quantum work statistics to characterize the controlled dynamics governed by a counterdiabatic driving field. Focusing on the Shannon entropy of the work probability distribution, P(W), we demonstrate that the thermodynamics of a controlled evolution serves as an insightful tool for studying the non-equilibrium dynamics of complex quantum systems. In particular, we show that the entropy of P(W) recovers the expected scaling according to the Kibble-Zurek mechanism for the Landau-Zener model. Furthermore, we propose that the entropy of the work distribution provides a useful summary statistic for characterizing the need and complexity of the control fields for many-body systems.
title: Трансформации суверенитета в эпоху информационной глобализации
Creators: name: Шипулин, Всеволод
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: Анализируется динамика представлений о суверенитете в философской и социально-политической мысли. Долгое время это понятие в основном рассматривалось как атрибут национального государства, независимого в своей внутренней и внешней политике, однако впоследствии стало также использоваться применительно к индивиду, суверенному в отношении самого себя. Особое внимание уделяется осмыслению феномена индивидуального суверенитета в контексте таких аспектов, как глобализация, способствующая кризису института национального государства и диверсификации трактовки суверенитета в классическом смысле, возникновение и популяризация либеральных и либертарианских представлений о правах и свободах человека как высшей ценности, а также трансформация коммуникативных моделей и способов самовыражения личности вследствие бурного развития информационных технологий. Отмечается, что формирующееся цифровое общество рождает новые возможности для становления инновационных форматов самосуверенной (self-sovereign) идентичности, индивидуального суверенитета, в том числе посредством регистрации и использования персонального цифрового ID. Прогнозируются и оцениваются связанные с этим социальные, политические, правовые последствия и риски.
Supplementary Material for: Einsatzerlebnisse, moralische Verletzungen, Werte und psychische Erkrankungen bei Einsatzsoldaten der Bundeswehr
Creators: name: Hellenthal, A.
name: Zimmermann, P.
name: Willmund, G.
name: Lovinusz, A.
name: Fiebig, R.
name: Bozoyan, C.
name: Maercker, A.
name: Alliger-Horn, C.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Hintergrund: Soldaten sind in militärischen Auslandseinsätzen vielfältigen belastenden Erlebnissen ausgesetzt, die zu erhöhten Raten an psychischen Erkrankungen führen. Moralische Verletzungen und Wertorientierungen scheinen in der Pathogenese dieser Erkrankungen eine Rolle zu spielen. Patienten und Methode: 191 Bundeswehrsoldaten erhielten zum Ende eines Einsatzes in Afghanistan eine Skala zu Einsatzerfahrungen (MHAT), die Posttraumatic Stress Diagnostic Scale (PDS), den Patient Health Questionnaire (PHQ-D), die Moral Injury Events Scale sowie den Portrait Values Questionnaire (PVQ). In Regressionsanalysen wurden direkte Assoziationen von Einsatzstressoren und Wertorientierungen mit psychischen Syndromen untersucht. In einer Mediationsanalyse wurden moralische Verletzungen als Mediator zwischen Einsatzerleben und psychischen Erkrankungen betrachtet. Ergebnisse: Der einsatzbezogene Stressor «Konfrontation mit Not, Leid, Gewalt in der Bevölkerung» zeigte einen direkten signifikanten Einfluss auf psychische Erkrankungen. Moralische Verletzungen stellten eine differenziell vermittelnde Variable zwischen dem Stressor «Konfrontation mit Not, Leid, Gewalt in der Bevölkerung» und den psychischen Syndromen «posttraumatische Belastungsstörung» und «Depressivität» einerseits und Alkoholmissbrauch andererseits dar. Keine signifikanten Zusammenhänge ergaben sich zwischen traditionellen Werthaltungen und psychischen Erkrankungen sowie zwischen traditionellen Werthaltungen und moralischen Verletzungen. Schlussfolgerung: Einsatzerlebnisse mit moralischer Dimension scheinen eine besonders starke Rolle in Bezug auf psychische Erkrankungen bei Bundeswehrsoldaten zu spielen. Der Effekt wird über das Konstrukt moralischer Verletzungen vermittelt. Diese Ergebnisse können zur Weiterentwicklung präventiver und therapeutischer Maßnahmen beitragen.
Flow cytometry-based platelet function testing is predictive of symptom burden in a cohort of bleeders
Creators: name: Boknäs, Niklas
name: Ramström, Sofia
name: Faxälv, Lars
name: Lindahl, Tomas L.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: Platelet function disorders (PFDs) are common in patients with mild bleeding disorders (MBDs), yet the significance of laboratory findings suggestive of a PFD remain unclear due to the lack of evidence for a clinical correlation between the test results and the patient phenotype. Herein, we present the results from a study evaluating the potential utility of platelet function testing using whole-blood flow cytometry in a cohort of 105 patients undergoing investigation for MBD. Subjects were evaluated with a test panel comprising two different activation markers (fibrinogen binding and P-selectin exposure) and four physiologically relevant platelet agonists (ADP, PAR1-AP, PAR4-AP, and CRP-XL). Abnormal test results were identified by comparison with reference ranges constructed from 24 healthy controls or with the fifth percentile of the entire patient cohort. We found that the abnormal test results are predictive of bleeding symptom severity, and that the greatest predictive strength was achieved using a subset of the panel, comparing measurements of fibrinogen binding after activation with all four agonists with the fifth percentile of the patient cohort (p = 0.00008, hazard ratio 8.7; 95% CI 2.5–40). Our results suggest that whole-blood flow cytometry-based platelet function testing could become a feasible alternative for the investigation of MBDs. We also show that platelet function testing using whole-blood flow cytometry could provide a clinically relevant quantitative assessment of platelet-related hemostasis.
Das asynchrone Videointerview - Eine explorative Untersuchung, wie potentielle Bewerberinnen und Bewerber das neue Rekrutierungstool erleben
Creators: name: Zenger, Laura
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2018

description: Das neue Rekrutierungstool asynchrones Videointerview kann sowohl örtliche wie auch zeitliche Grenzen überwinden. Für Unternehmen birgt es deshalb viele Vorteile. Doch wie erleben Bewerbende das asynchrone Videointerview? Um diese Fragestellung beantworten zu können, wurde ein exploratives Untersuchungsdesign gewählt. In einem ersten Schritt wurden qualitative Interviews durchgeführt, deren Ergebnisse in die darauf aufbauende quantitative Erhebung einflossen. Die potentiellen Bewerber und Bewerberinnen zeigten eine mittlere Haltung gegenüber dem asynchronen Videointerview. Dank den quantitativen Ergebnissen konnten sowohl positive wie auch negative Aspekte des asynchronen Videointerviews aufgezeigt werden. Zudem wurden verbesserungswürdige Aspekte ausgemacht, die als Gestaltungsmassnahmen für die Praxis zusammengefasst wurden.
Development of a novel in vitro assay to evaluate environmental water using an IL-8 reporter cell line
Creators: name: Kimura, Yutaka
name: Fujimura, Chizu
name: Imagawa, Toshifumi
name: Lupisan, Socorro P.
name: Saito-Obata, Mariko
name: Saito, Mayuko
name: Oshitani, Hitoshi
name: Aiba, Setsuya
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2020
Subjects: Toll-like receptors
NOD-like receptors
IL-8
Luciferase assay
monocyte
hapten

description: The IL-8 luciferase reporter cell line, THP-G8 cells, used in the in vitro sensitization test, OECD442E, can respond to a variety of stimuli other than haptens, such as lipopolysaccharide (LPS), other bacterial toxins, and detergents. Considering these characteristics, we examined the ability of the IL-8 luciferase assay using THP-G8 cells to evaluate water pollution. We first stimulated THP-G8 cell with various Toll-like receptor (TLR) agonists and nucleotide-binding oligomerization domain-like receptor (NLR) agonists, and found that TLR1, 2, 4, 5, 6 agonists and NOD 1, 2 agonists significantly augmented IL-8 luciferase activity (IL8LA). Then, we examined the detection threshold of LPS by THP-G8 cells, and found it 0.4 EU/ml. Next, we examined whether THP-G8 cells can differently respond to a variety of sources of environmental water around Sendai, Japan and Manila, Philippine and whether there is a correlation between the IL8LA of different sources of water and their level of endotoxin assessed by the LAL assay. There was a clear trend that the IL8LA was lower in the upper stream and higher in the downstream in both Japan and Philippine. Moreover, there was a strong correlation between the IL8LA of the environmental water and its endotoxin level. Finally, using N-acetyl-L-cysteine, an antioxidant/radical scavenger, and polymyxin B that neutralizes endotoxin, we demonstrated that there was a difference in the suppressive effects by them between the water from Japan and that from Philippine. These data suggest the potential of the IL-8 luciferase assay for evaluating environmental water pollution both quantitatively and qualitatively.
description: EXCLI Journal; 19:Doc1054; ISSN 1611-2156
title: ADCO, Cartulaire de Cîteaux pour les possessions d’Izeure (XVe siècle), Cart. 178 (11 H 80), 82 folios, f. 0089
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2015
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Cartulaire de Cîteaux pour les possessions d’Izeure (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 178 (11 H 80), 82 folios, f. 0089, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de Cîteaux pour les possessions d’Izeure (XVe siècle), Archives départementales de la Côte-d'Or, Cart. 178 (11 H 80), 82 folios, f. 0089, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Von Koordination zur Ko-Kreation im digitalen Planungs- und Bauprozess
Creators: name: Schulze, Hartmut
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2020
Subjects: subject: Digitale Planung im Bauwesen
subject: Kooperation und Zusammenarbeit
subject: 100 - Philosophie und Psychologie
subject: 300 - Sozialwissenschaften
subject: 600 - Technik, Medizin, angewandte Wissenschaften

description: Schaffung zusammenarbeitsförderlicher Bedingungen und Voraussetzungen: 1. Schaffung gemeinsamer Zielstellungen und Interdependenzen der beteiligten Partner 2. Incentivierungvon gemeinsamem Erfolg 3. Systematische Integration von Teams in den Planungs-und Bauprozess 4. Soziale Präsenz und informelle Kommunikation als Grundlage für gegenseitiges Vertrauen 5. Räumliche und technische Bedingungen förderlich für Austausch und Ko-Kreation 6. Perspektive: Soziale Austauschtheorie und «psychologischer Vertrag»
A POLUIÇÃO DO SOLO: CAUSAS, FONTES E PRINCIPAIS POLUENTES
Creators: name: Ribeiro, Ondina
name: Briones, Maria J.L.
name: Ribeiro, Cláudia
name: Natal-Da-Luz, Tiago
name: Sousa, João Ricardo
name: Carrola, João Soares
Publisher: name: Revista Captar: Ciência e Ambiente para Todos
Year: 2024

description: O solo é um recurso importante para os ecossistemas, a vida selvagem e para a agricultura. Desde a revolução industrial, milhares de compostos têm sido utilizados, produzidos e libertados involuntariamente ou até de forma voluntária (caso dos pesticidas e bombas) para o ambiente afetando os solos. Diversas fontes e vários tipos de poluentes vão afetar a fauna do solo, os ecossistemas aquáticos e as cadeias alimentares. Estes compostos podem ser bioacumulados e bioamplificados o que os torna ainda mais problemáticos, nomeadamente: metais pesados/metaloides, fertilizantes orgânicos e minerais, plásticos, pesticidas, hidrocarbonetos aromáticos policíclicos, poluentes orgânicos persistentes, fármacos e produtos de higiene pessoal, dioxinas e explosivos. Estes tóxicos acabam por estar presentes sob a forma de misturas que contribuem para a perturbação da fauna edáfica, poluição das culturas, contaminação das linhas de água e lençóis freáticos, e para uma perda progressiva da biodiversidade. O conhecimento das fontes, dos efeitos e mecanismos associados a esses contaminantes no funcionamento do ecossistema terrestre é fundamental para se poder evitar/prevenir os impactos irreversíveis e assim preservar a saúde do solo, a produção de alimentos saudáveis e a continuidade dos serviços de ecossistema, vitais para a sobrevivência e bem-estar do ser humano.


 
description: Revista Captar: Ciência e Ambiente para Todos, Vol 13 (2024)
Application of a semi-automatic cartilage segmentation method for biomechanical modeling of the knee joint
Creators: name: Liukkonen, Mimmi K.
name: Mononen, Mika E.
name: Tanska, Petri
name: Saarakkala, Simo
name: Nieminen, Miika T.
name: Korhonen, Rami K.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Manual segmentation of articular cartilage from knee joint 3D magnetic resonance images (MRI) is a time consuming and laborious task. Thus, automatic methods are needed for faster and reproducible segmentations. In the present study, we developed a semi-automatic segmentation method based on radial intensity profiles to generate 3D geometries of knee joint cartilage which were then used in computational biomechanical models of the knee joint. Six healthy volunteers were imaged with a 3T MRI device and their knee cartilages were segmented both manually and semi-automatically. The values of cartilage thicknesses and volumes produced by these two methods were compared. Furthermore, the influences of possible geometrical differences on cartilage stresses and strains in the knee were evaluated with finite element modeling. The semi-automatic segmentation and 3D geometry construction of one knee joint (menisci, femoral and tibial cartilages) was approximately two times faster than with manual segmentation. Differences in cartilage thicknesses, volumes, contact pressures, stresses, and strains between segmentation methods in femoral and tibial cartilage were mostly insignificant (p > 0.05) and random, i.e. there were no systematic differences between the methods. In conclusion, the devised semi-automatic segmentation method is a quick and accurate way to determine cartilage geometries; it may become a valuable tool for biomechanical modeling applications with large patient groups.
title: PP_1961-1962_Esquisse d'entraînement_Un baptistère
Creators: name: Panerai, Philippe
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2024
Subjects: subject: architecture
subject: beaux-arts
subject: Écoles des beaux-arts
subject: enseignement
subject: Atelier Arretche

description: Travaux scolaires de Philippe Panerai à l'École des beaux-arts.
Français pour les bilingues 5e/6e: La pub
Creators: name: Trommer, Bernadette
name: Egli, Mirjam
name: Oliveira, Marta
Publisher: name: Pädagogische Hochschule FHNW
Year: 2020
Subjects: subject: français
subject: bilingue
subject: école primaire
subject: 440 - Französisch, romanische Sprachen allgemein
subject: 370 - Erziehung, Schul- und Bildungswesen

description: Die Lernparcours sind spezifische Materialien, um französischsprachige Kinder, die in der Deutschschweiz den Fremdsprachenunterricht Französisch auf der Primarstufe besuchen, angemessen zu fördern.
A two-step theory and test of the oil curse: the conditional effect of oil on democratization
Creators: name: Houle, Christian
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Does oil impede democratization? This article posits that in order to understand the effect of oil on democratization one has to decompose the transition process into two steps: (1) the ending of the authoritarian regime, which initiates the process; and (2) the subsequent establishment of a democracy rather than an autocracy. I argue that oil has different effects on the two phases of the transition process: while oil has contradictory effects on the likelihood that an authoritarian regime fails, it diminishes the likelihood of the establishment of democracy following the failure. Oil’s negative effect is conditional on the breakdown of the authoritarian regime, which itself is unaffected by oil. That is, although oil does not initiate the transition process, it does influence its outcome. Using data on 118 autocracies, I find evidence consistent with this hypothesis.
Two Voices for What: A tragicomedy or a romantic comedy or some dinner theatre or “just” liner notes on some sleeve (not of a jacket, no, but on – what – a recording)
Creators: name: Latimer, Quinn
Publisher: name: edition fink
Year: 2020
Subjects: Fortsetzung folgt
edition fink
Georg Rutishauser
Quinn Latimer
Marion Ritzmann
Claudiabasel

description: Published as part of “Fortsetzung folgt” by Marion Ritzmann / adhesive binding, cardboard book. Textbuch / Teilpublikation aus: Fortsetzung folgt
Haptic Exploratory Procedures of Children and Youth with and without Cerebral Palsy
Creators: name: Taylor, Susan
name: Girdler, Sonya
name: McCutcheon, Sara
name: McLean, Belinda
name: Parsons, Richard
name: Falkmer, Torbjorn
name: Jacoby, Peter
name: Carey, Leeanne
name: Elliott, Catherine
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 4201
subject: Allied health and rehabilitation science
classificationCode: 3213
subject: Paediatrics

description: Aims: Compare haptic exploratory procedures (EPs) and exploratory movements (EMs) of children. This study also tested the interrater reliability of a novel digital recording method. Methods: Participants were 31 children with typical development (TD) (aged 6 years 1 month to 15 years 9 months; 14 male) and 23 children with spastic unilateral cerebral palsy (CP) (aged 6 years to 15 years 5 months; 13 males; right hemiplegia, n = 12). Results: There were no statistically significant differences between groups for expected EP (p =.15), additional EPs (p =.78), or EMs (p =.69) but there was for mean duration of exploration (p <.001) and accuracy (p <.001). This suggests that although children with CP performed similar haptic EPs for each object as children with TD, they took more time and were less accurate in their identification. There was substantial agreement between the two raters' observations of expected EP, κ =.64, p <.0005. Conclusion: Children with CP performed similar haptic EPs as their TD peers. However, despite similarities, the results indicate that for children with CP manual ability was not the primary determinant of accuracy or speed of identification. This study provides evidence for a reliable method of recording haptic EPs.
Supplementary Material for: An Open-Label Study of the Long-Term Safety of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis (RECAP)
Creators: name: Costabel, U.
name: Albera, C.
name: Lancaster, L.H.
name: Lin, C.-Y.
name: Hormel, P.
name: Hulter, H.N.
name: Noble, P.W.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Background: RECAP (NCT00662038) was an open-label extension study in patients with idiopathic pulmonary fibrosis (IPF) who completed either the Assessment of Pirfenidone to Confirm Efficacy and Safety in Idiopathic Pulmonary Fibrosis (ASCEND) 016 phase 3 trial or the Clinical Studies Assessing Pirfenidone in Idiopathic Pulmonary Fibrosis: Research of Efficacy and Safety Outcomes (CAPACITY) 004/006 phase 3 trials. Objective: To obtain long-term safety data for pirfenidone in patients with IPF in RECAP. Methods: Of the 1,334 patients who participated in the phase 3 trials, 1,058 entered RECAP. The final analysis from enrollment (September 2008) to June 2015 is presented. Results: Mean (SD) and median (range) pirfenidone exposures in RECAP were 122 (98) weeks and 88 (>0 to 349) weeks, respectively, with a mean daily dose of 2,091.1 mg. Cumulative total exposure was 2,482 patient exposure years (PEY). The treatment-emergent adverse event (TEAE) rate was 701.9 per 100 PEY. The serious TEAE rate was 53.5 per 100 PEY, with the most common serious TEAE being IPF (11.1 per 100 PEY). Of the 231 deaths (9.3 per 100 PEY), the most common cause was IPF (5.4 per 100 PEY). The treatment discontinuation rate due to a TEAE was 17.9 per 100 PEY; discontinuations were due to IPF (7.2 per 100 PEY), pneumonia, respiratory failure, acute respiratory failure, rash (0.5 per 100 PEY each), and nausea (0.4 per 100 PEY). For patients from CAPACITY 004/006 who entered RECAP, the mean change in percent predicted forced vital capacity from RECAP baseline at 180 weeks was -9.6%. Median on-treatment survival from the first pirfenidone dose in RECAP was 77.2 months. Conclusions: RECAP provides long-term follow-up and safety data for pirfenidone that were consistent with the known profile, with no new safety signals observed.
Kindern Wege in Natur und Technik erschliessen
Creators: name: Lüscher, Andrea Denise
name: Beerenwinkel, Anne
Publisher: name: Aargauischer Lehrerinnen- und Lehrerverband (alv)
Year: 2018
Subjects: subject: Natur und Technik
subject: Zyklus 1
subject: schulhausinterne Weiterbildung
subject: 370 - Erziehung, Schul- und Bildungswesen
subject: 500 - Naturwissenschaften

description: Natur und Technik mit Freude und Sicherheit im Kindergarten und Primarschule thematisieren: Das Projekt «KiNaT» bietet dazu eine schulhaus­interne Pilot-­Weiterbildung.
Supplementary Material for: Macrophage-Derived Chemokine: A Putative Marker of Pharmacological Therapy Response in Major Depression?
Creators: name: Milenkovic, V.M.
name: Sarubin, N.
name: Hilbert, S.
name: Baghai, T.C.
name: Stöffler, F.
name: Lima-Ojeda, J.M.
name: Manook, A.
name: Almeqbaali, K.
name: Wetzel, C.H.
name: Rupprecht, R.
name: Nothdurfter, C.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Introduction: Inflammatory processes play an important and complex role in the pathophysiology of major depressive disorder (MDD), but, so far, no specific investigation of chemokines exists. Methods: In this study, we investigated the changes of plasma chemokine levels (eotaxin-1, eotaxin-3, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, and TARC) in 47 MDD patients before (PRE) and after 1 and 6 weeks of pharmacological treatment (POST1 and POST6) in relation to the response to antidepressive therapy. We hypothesized that the direction of alterations in levels of chemokines would significantly differ between the 2 groups, responders and nonresponders. Results: Among the investigated chemokines, only the level of macrophage-derived chemokine (MDC) changed significantly in relation to therapy response. MDC levels were significantly elevated in the responder group at POST6. Discussion: MDC is a constitutively expressed chemokine involved in the pathophysiology of infectious and neoplastic diseases. This is the first study providing valuable hints that MDC might serve as a marker of pharmacological therapy response in MDD.
Aus der Forschung 2. Den sprachlichen Austausch initiieren
Creators: name: Lüscher, Andrea Denise
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2020
Subjects: Unterrichtsgespräche
Zyklus 1
Experimentieren
Natur und Technik

description: Im Artikel wird aufgezeigt, wie Gesprächskonferenzen mit 4- bis 8-jährigen Kindern initiiert werden können.