cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
History of faulting in the Northern Hastings Block, southern New England Orogen
Creators: name: J. Yan
name: P.G. Lennox
name: R. Offler
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Brittle failure is common in the Devonian to Permian rocks in the Northern Hastings Block (NHB) and is manifested by faults of different orientation and kinematic histories, but the timing of fault movement is not well defined. In this study, faults in the NHB were analysed with the map pattern of cross-cutting faults used to estimate the relative time of movement and relationship to other faults. We defined five episodes of faulting or fault reactivation that affected the NHB. The Yarras Fault System on the southwestern side of the NHB and the Parrabel Fault and related faults on the eastern side of the NHB are the two major fault systems responsible for transporting and rotating the NHB in the late Carboniferous. Faults on the eastern, northeastern and northern part of Parrabel Dome started and stopped moving after emplacement of the Hastings Block and before the intrusion of the Werrikimbe Triassic granitoids. We suggested that the movement on the major bounding faults is related to the accommodation of the NHB to the folding and cleavage development in the adjoining Nambucca Block, and is associated with the earliest part of the Hunter–Bowen Orogeny. Limited dextral movement on the extensions of the Taylors Arm Fault System caused minor displacements in the northeastern part of the NHB during the Late Triassic. Some small faults cut the Triassic granitoids or Triassic Lorne Basin sediments indicating tectonic activity continued post-Triassic.
Implementation of the patient-derived explant (PDE) platform for evaluating tumour responses to novel immunotherapies and BRAF inhibitors
Creators: name: Abid, Naila
Publisher: name: University of Leicester
Year: 2024

description: Melanoma is a leading cause of skin cancer deaths, often progressing to metastasis and treatment resistance after surgery. Many oncology drugs fail in clinical trials due to inadequate preclinical models predictive of patient outcome, especially for immune checkpoint inhibitors (ICIs), necessitating accurate predictive models. We have established a metastatic melanoma (MM) PDE pre-clinical model, which represents the “live” culture of MM tumour fragments and retains tumour architecture intact. These cultures were used to test and predict the responses to ICIs. BRAF is the most common mutation in melanoma and BRAF inhibitors have been known to be effective.Tumours obtained from surgery were sectioned into explants and cultured for 16-24 h. PDEs were transferred into fresh media containing ICIs and BRAF inhibitors for 24h and then fixed, and formalin fixed paraffin embedded (FFPE) blocks generated. Multi-immunofluorescence (mIF) staining coupled to digital pathology tools was used to segment tumour and stroma areas, followed by quantitation of proliferation (Ki67) and cell death (cPARP) response to the drugs. Key immunological subsets (CD4, CD8, FOXP3) were evaluated using mIF to investigate the density of key immune cells in response to treatments.Differential apoptotic responses to ICIs as well as BRAF inhibitors (i) across the MM-PDEs were observed which matched clinical outcomes, with the highest response rate to α-PD1 inhibition and combination treatment (αPD1+ α-CTLA4) and (BARFi + MEKi). Differential levels of CD4+FOXP3+ regulatory T cells and CD8+ Cytotoxic T Lymphocytes (CTLs) infiltration into stroma and tumour areas of the MM-PDEs was observed. This allowed us to distinguish immune “hot” and “cold” tumours and correlate this status with cell death induction by ICIs and patient outcomes in the clinic.Positive correlations of intrinsic CTL densities with positive patient outcomes and negative correlation of intrinsic CTL density with ICI treated PDEs and cell death were found. Further analysis of these data with clinical comparisons, will allow us to understand the extent to which the MM-PDEs are predictive of patient outcomes in the preclinical testing of ICIs.
The Great Inundation of 1771 and the Rebuilding of the North-East's Bridges
Creators: name: Rennison, R W
Publisher: name: Archaeology Data Service
Year: 2019

description: Archaeologia Aeliana, 29, 269-291
description: Mostly historical. Reports on major floods in AD 1771, which led to the destruction (and subsequent rebuilding) of many of the area's bridges. Documents the architecture of some of the bridges. Includes an:
Merging teaching and research: how to use your teaching to increase your research outputs
Creators: name: Byrd, Hugh
Publisher: name: University of Lincoln
Year: 2024
Subjects: K100 - Architecture
X142 - Training teachers - higher education

description: We all need research outputs for:We all need research outputs for:Promotion,job applications,peer esteem,attracting good students,evidence for attracting fundingThis presentation is for architectural staff and gives some examples of how to make the most of teaching so that it can be converted into research outputs
Merging teaching and research: how to use your teaching to increase your research outputs
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2024
Subjects: K100 - Architecture
X142 - Training teachers - higher education

description: We all need research outputs for:We all need research outputs for:Promotion,job applications,peer esteem,attracting good students,evidence for attracting fundingThis presentation is for architectural staff and gives some examples of how to make the most of teaching so that it can be converted into research outputs
10 ways to improve NSS results
Creators: name: Byrd, Hugh
Publisher: name: University of Lincoln
Year: 2024
Subjects: K100 - Architecture
X142 - Training teachers - higher education

description: This presentation is a series of suggestions and ideas for improving NSS results in an architectural course, though much of it is applicable to other design-based courses.The slides are not intended to be in any order of priority.50 practical suggestions around 10 themes that correspond to NSS questions
10 ways to improve NSS results
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2024
Subjects: K100 - Architecture
X142 - Training teachers - higher education

description: This presentation is a series of suggestions and ideas for improving NSS results in an architectural course, though much of it is applicable to other design-based courses.The slides are not intended to be in any order of priority.50 practical suggestions around 10 themes that correspond to NSS questions
Career progression: taking your place
Creators: name: Byrd, Hugh
Publisher: name: University of Lincoln
Year: 2024
Subjects: K100 - Architecture
X142 - Training teachers - higher education

description: My intention is to give you ideas of how you can best prepare yourself for improving your position.There is no optimum method of doing this. It depends on what you want and where you want to go.A position will not be given to you; you must take your placeWhat I will show you are the basic rules of the game for improving your CV, staff profile and responses at interviews.
Career progression: taking your place
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2024
Subjects: K100 - Architecture
X142 - Training teachers - higher education

description: My intention is to give you ideas of how you can best prepare yourself for improving your position.There is no optimum method of doing this. It depends on what you want and where you want to go.A position will not be given to you; you must take your placeWhat I will show you are the basic rules of the game for improving your CV, staff profile and responses at interviews.
Students as producers - cooperation with AEC (Abundant Earth Community) 2013-2014 [action research contribution]
Creators: name: Kolakowski, Marcin MA
Publisher: name: University of Lincoln
Year: 2024
Subjects: K100 - Architecture
X142 - Training teachers - higher education
X341 - Academic studies in further education
X342 - Academic studies in higher education
X390 - Academic studies in education not elsewhere classified
X990 - Education not elsewhere classified

description: Visions for Architectural Education â€“ Unpublished voice in internal departmental discussion in University of Lincoln about forms of education [Action Research Contribution]In 2013 and 2014 group of 2nd year architecture students have designed project for one most interesting Lincolnshire housing cooperative group â€“ Abundant Earth Community (A.E.C.). The project was facilitated by dr. Marcin M. Ko?akowski who found opportunity in leasing with â€“ A.E.C. , which is a recently established group aiming to set up a co-housing cooperative community of people committed to idea of shearing, and deeply ecological work/live model
Students as producers - cooperation with AEC (Abundant Earth Community) 2013-2014 [action research contribution]
Creators: name: Kolakowski, Marcin
Publisher: name: University of Lincoln
Year: 2024
Subjects: K100 - Architecture
X142 - Training teachers - higher education
X341 - Academic studies in further education
X342 - Academic studies in higher education
X390 - Academic studies in education not elsewhere classified
X990 - Education not elsewhere classified

description: Visions for Architectural Education â€“ Unpublished voice in internal departmental discussion in University of Lincoln about forms of education [Action Research Contribution]In 2013 and 2014 group of 2nd year architecture students have designed project for one most interesting Lincolnshire housing cooperative group â€“ Abundant Earth Community (A.E.C.). The project was facilitated by dr. Marcin M. Ko?akowski who found opportunity in leasing with â€“ A.E.C. , which is a recently established group aiming to set up a co-housing cooperative community of people committed to idea of shearing, and deeply ecological work/live model
Uniqueness, challenges and dilemmas of teaching first year architecture
Creators: name: Kolakowski, Marcin MA
Publisher: name: University of Lincoln
Year: 2024
Subjects: K100 - Architecture
X142 - Training teachers - higher education
X341 - Academic studies in further education
X342 - Academic studies in higher education
X390 - Academic studies in education not elsewhere classified
X990 - Education not elsewhere classified

description: Visions for Architectural Education â€“ Unpublished voice in internal departmental discussion about forms of education [Action Research Contribution]Everyone who ever taught the first year must have felt its uniqueness. Literature as much as internet forums of academics involved in teaching the first year clearly show patterns pointing out the uniqueness, challenges and dilemmas which all define the importance of this phase of teaching design.- For most first-year students, enrolment on the architecture course marks the beginning of a new chapter in life with many lifestyle changes. For some of them, this could be an unpleasant experience as they might feel homesick and overwhelmed with new responsibilities. For others, this might mean an unprecedented excitement of freedom, new circles of friends, etc. New exciting attractions may be a distraction which could compete with learning. On the other hand, the beginning of new period in life could be connected with unique openness and engagement, almost like â€œNew Yearâ€™s resolutionsâ€ . The highest attendance and engagement is observed at the beginning of the academic year. - In order to release studentsâ€™ creative energy and create a synergy between studentsâ€™ new lifestyle, we decided to join social and learning activities. The expectations that group work and versatile activities would keep the momentum were confirmed.
Uniqueness, challenges and dilemmas of teaching first year architecture
Creators: name: Kolakowski, Marcin
Publisher: name: University of Lincoln
Year: 2024
Subjects: K100 - Architecture
X142 - Training teachers - higher education
X341 - Academic studies in further education
X342 - Academic studies in higher education
X390 - Academic studies in education not elsewhere classified
X990 - Education not elsewhere classified

description: Visions for Architectural Education â€“ Unpublished voice in internal departmental discussion about forms of education [Action Research Contribution]Everyone who ever taught the first year must have felt its uniqueness. Literature as much as internet forums of academics involved in teaching the first year clearly show patterns pointing out the uniqueness, challenges and dilemmas which all define the importance of this phase of teaching design.- For most first-year students, enrolment on the architecture course marks the beginning of a new chapter in life with many lifestyle changes. For some of them, this could be an unpleasant experience as they might feel homesick and overwhelmed with new responsibilities. For others, this might mean an unprecedented excitement of freedom, new circles of friends, etc. New exciting attractions may be a distraction which could compete with learning. On the other hand, the beginning of new period in life could be connected with unique openness and engagement, almost like â€œNew Yearâ€™s resolutionsâ€ . The highest attendance and engagement is observed at the beginning of the academic year. - In order to release studentsâ€™ creative energy and create a synergy between studentsâ€™ new lifestyle, we decided to join social and learning activities. The expectations that group work and versatile activities would keep the momentum were confirmed.
Ontik Zaman Fenomeninin Epistemolojik Yansıması
Creators: name: Çetin, Esad
Publisher: name: figshare
Year: 2020
Subjects: subject: 220314 Philosophy of Mind (excl. Cognition)
subject: FOS: Philosophy, ethics and religion

description: Abstract: This paper focuses on the philosophical ground constituted between “Language” and “Logic”, which should be coined as “synthetic ways” because the synthesis of “Logic” and “Language” is “the science of Logic” as one of the synthetic ways of synthesis by the “mind”. When we look into the historical development of this synthesis process, we see very different synthetic opera-tions, compared with those which are in modern times and in terms of funda-mental dynamics. Thus, this article aims to show that the dynamic of “time” is in interaction with the dynamic of “motion” –so the dynamic of “changing”. It also aims to how that that the quality of the interaction between those dynam-ics is coming true because of the difference in understanding the category of “quantity” by the views of different philosophers. For instance, according to Aristotle, categories belong to being; but in Kant, categories belong to the mind that will perceive the being. Hence, this study aims to show the differ-ence in understanding the “being” and the one who perceives it from a different perspective.
How not to teach self-centred, object-centred and image-centred design? Action research
Creators: name: Kolakowski, Marcin MA
Publisher: name: University of Lincoln
Year: 2024
Subjects: K100 - Architecture
X142 - Training teachers - higher education
X341 - Academic studies in further education
X342 - Academic studies in higher education
X390 - Academic studies in education not elsewhere classified
X990 - Education not elsewhere classified

description: Ongoing Action Research on architectural education. Based on [PGCE pedagogical Portfolio] â€“Final Thesis Dr Marcin Mateusz Ko?akowski (Ph.D, in?. arch., Dipl, -Ing) Supervisor: Dr. Sarah AmslerUniversity of Lincoln: May 2014University of Lincoln: February 2014Visions for Architectural Education â€“ Unpublished voice in internal departmental discussion about forms of education [Action Research Contribution]Ongoing Action Research about architectural education. During the years 2010 and 2011, the Department of Architecture underwent a series of substantial changes. They were particularly visible in the first year of the BA course, where methods and contents of teaching were changed considerably. The aim of this research is to evaluate the changes that were undertaken.
626430410_09_Cetin_(713-728).pdf
Creators: name: Çetin, Esad
Publisher: name: figshare
Year: 2020
Subjects: subject: 220314 Philosophy of Mind (excl. Cognition)
subject: FOS: Philosophy, ethics and religion

description: Abstract: This paper focuses on the philosophical ground constituted between “Language” and “Logic”, which should be coined as “synthetic ways” because the synthesis of “Logic” and “Language” is “the science of Logic” as one of the synthetic ways of synthesis by the “mind”. When we look into the historical development of this synthesis process, we see very different synthetic opera-tions, compared with those which are in modern times and in terms of funda-mental dynamics. Thus, this article aims to show that the dynamic of “time” is in interaction with the dynamic of “motion” –so the dynamic of “changing”. It also aims to how that that the quality of the interaction between those dynam-ics is coming true because of the difference in understanding the category of “quantity” by the views of different philosophers. For instance, according to Aristotle, categories belong to being; but in Kant, categories belong to the mind that will perceive the being. Hence, this study aims to show the differ-ence in understanding the “being” and the one who perceives it from a different perspective.
The Conservation Treatment of a Plan of Newcastle upon Tyne by James Corbridge
Creators: name: Arribas, �Ngels
Publisher: name: Archaeology Data Service
Year: 2019

description: Archaeologia Aeliana, 29, 293-297
description: Summarises the methodology and results of the recent conservation of the Plan of Newcastle, a map produced in 1723 which depicts the layout of the town and features twenty-six images of important buildings within its margin.
How not to teach self-centred, object-centred and image-centred design? Action research
Creators: name: Kolakowski, Marcin
Publisher: name: University of Lincoln
Year: 2024
Subjects: K100 - Architecture
X142 - Training teachers - higher education
X341 - Academic studies in further education
X342 - Academic studies in higher education
X390 - Academic studies in education not elsewhere classified
X990 - Education not elsewhere classified

description: Ongoing Action Research on architectural education. Based on [PGCE pedagogical Portfolio] â€“Final Thesis Dr Marcin Mateusz Ko?akowski (Ph.D, in?. arch., Dipl, -Ing) Supervisor: Dr. Sarah AmslerUniversity of Lincoln: May 2014University of Lincoln: February 2014Visions for Architectural Education â€“ Unpublished voice in internal departmental discussion about forms of education [Action Research Contribution]Ongoing Action Research about architectural education. During the years 2010 and 2011, the Department of Architecture underwent a series of substantial changes. They were particularly visible in the first year of the BA course, where methods and contents of teaching were changed considerably. The aim of this research is to evaluate the changes that were undertaken.
BERA Bites 6 - Researching education & mental health: From â€˜Where are we now?â€™ to â€˜What next?â€™
Creators: name: Jayman, Michelle
name: Glazzard, Jonathan
name: Rose, Anthea
Publisher: name: University of Lincoln
Year: 2024
Subjects: X120 - Training teachers - primary
X141 - Training teachers - further education
X190 - Training teachers not elsewhere classified
X990 - Education not elsewhere classified

description: The world has changed dramatically since these articles first appeared online. As we continue to endure the global pandemic, the urgency of the issues highlighted in this collection on mental health and wellbeing in education has never resonated more profoundly. The mental health and wellbeing of learners and teaching staff rank among some of the most pressing issues facing education in the early 2020s.1 Growing rates of emotional distress among school-aged children, the impact of relentless workloads on teacher wellbeing, and the seismic effects of acute low-level funding and childhood poverty are common concerns. These were some of the critical areas for research attention highlighted at our special interest groupâ€™s inaugural conference â€“ Researching Education and Mental Health: Where Are We Now?2 â€“ in July 2019. The event brought together researchers, academics and practitioners from contexts ranging from early years to higher education to discuss worries, consider practical solutions and set a dynamic research agenda moving forward. This edition of BERA Bites presents a collection of papers from the conference, first presented as a special issue of the BERA Blog, 3 and features ground-breaking projects supporting mental health and wellbeing in education as well as showcasing some of the latest studies to emerge, collectively helping to steer the research agenda in this crucial area
Efficient synthesis of (S,S)-2,8-diazabicyclo[4.3.0]nonane
Creators: name: Shipeng Chen
name: Dongqi Liu
name: Leilei Si
name: Ligong Chen
name: Xilong Yan
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: An efficient synthetic route for moxifloxacin chiral intermediate via five steps was established. First, dehydration, N-acylation, and cyclization were combined in one pot to meet the industrial requirement. Then relatively low hydrogen pressure was employed in the catalytic hydrogenation reaction with high yield. Isopropanol/water system was used in resolution, which guaranteed high yield and perfect optical purity. The racemic process conducted by manganese dioxide and Pd/C successfully converted the undesired enantiomer into the racemate and hence the total yield increased remarkably. Furthermore, mild hydrogen transfer catalytic hydrogenation method was utilized in debenzylation process instead of high-pressure hydrogenation. Total yield of 39.0% was achieved, which was much higher than that of 29.0% in literature.
BERA Bites 6 - Researching education & mental health: From Ã¢â‚¬ËœWhere are we now?Ã¢â‚¬â„¢ to Ã¢â‚¬ËœWhat next?Ã¢â‚¬â„¢
Creators: name: Author, Unknown
Publisher: name: University of Lincoln
Year: 2024
Subjects: X120 - Training teachers - primary
X141 - Training teachers - further education
X190 - Training teachers not elsewhere classified
X990 - Education not elsewhere classified

description: The world has changed dramatically since these articles first appeared online. As we continue to endure the global pandemic, the urgency of the issues highlighted in this collection on mental health and wellbeing in education has never resonated more profoundly. The mental health and wellbeing of learners and teaching staff rank among some of the most pressing issues facing education in the early 2020s.1 Growing rates of emotional distress among school-aged children, the impact of relentless workloads on teacher wellbeing, and the seismic effects of acute low-level funding and childhood poverty are common concerns. These were some of the critical areas for research attention highlighted at our special interest groupÃ¢â‚¬â„¢s inaugural conference Ã¢â‚¬â€œ Researching Education and Mental Health: Where Are We Now?2 Ã¢â‚¬â€œ in July 2019. The event brought together researchers, academics and practitioners from contexts ranging from early years to higher education to discuss worries, consider practical solutions and set a dynamic research agenda moving forward. This edition of BERA Bites presents a collection of papers from the conference, first presented as a special issue of the BERA Blog, 3 and features ground-breaking projects supporting mental health and wellbeing in education as well as showcasing some of the latest studies to emerge, collectively helping to steer the research agenda in this crucial area
The Vallum causeway and fort ditches at Great Chesters
Creators: name: Breeze, David J
name: Heywood, Brenda
Publisher: name: Archaeology Data Service
Year: 2019

description: Archaeologia Aeliana, 39, 1-7
description: An original causeway of boulder clay, revetted in neatly coursed stones, was discovered in 1950 across the Vallum, well to the south of the fort at Great Chesters. No evidence for a monumental gateway was found. The ditch was filled with silt when it was capped by a layer of clay on which lay a secondary road surface overlapping the eastern part of the causeway. To the east of the fort, two ditches were located which may correspond to the two outer ditches to the west.
Students as explorers - cooperation with EMESS (East Midlands Earth Structure Society) 2011-2014 [action research contribution]
Creators: name: Kolakowski, Marcin MA
Publisher: name: University of Lincoln
Year: 2024
Subjects: K100 - Architecture
X142 - Training teachers - higher education
X341 - Academic studies in further education
X342 - Academic studies in higher education
X390 - Academic studies in education not elsewhere classified
X990 - Education not elsewhere classified

description: Visions for Architectural Education â€“ Unpublished voice in internal departmental discussion about forms of education [Action Research Contribution]This adventure started when dr. Marcin M. Ko?akowski, who isresearching natural and alternative architecture, decided to attend ameeting organised by a local group of practitioners and enthusiasts oflocal architecture called EMESS (East Midland Earth StructureSociety). 'Strike while the iron is hot!' said Chairman David Glew andalready at that meeting they started to sketch plans for cooperationand for future practical workshops for students.It was 3 years ago and since then students of architecture had achance to participate in three workshops, each of them with adifferent character. During the first one in 2012, students had anopportunity to meet Prof Louis Nelson from the University of Virginiaand listen to his talk about the application of Lincolnshire methodsin America. In 2013, students got involved in a real renovationproject. That year, students had a chance to participate in intensiveworkshops at Tumby Moorside Barn, where five specialists introducedstudents to key aspects of building conservation. Despite being alisted building, the barn uniquely received a permission to holdworkshops there. It does not happen often that a listed building canbe experimented on, but thanks to this arrangement our students got areal insight into traditional details, which they could touch andrepair.
Students as explorers - cooperation with EMESS (East Midlands Earth Structure Society) 2011-2014 [action research contribution]
Creators: name: Kolakowski, Marcin
Publisher: name: University of Lincoln
Year: 2024
Subjects: K100 - Architecture
X142 - Training teachers - higher education
X341 - Academic studies in further education
X342 - Academic studies in higher education
X390 - Academic studies in education not elsewhere classified
X990 - Education not elsewhere classified

description: Visions for Architectural Education â€“ Unpublished voice in internal departmental discussion about forms of education [Action Research Contribution]This adventure started when dr. Marcin M. Ko?akowski, who isresearching natural and alternative architecture, decided to attend ameeting organised by a local group of practitioners and enthusiasts oflocal architecture called EMESS (East Midland Earth StructureSociety). 'Strike while the iron is hot!' said Chairman David Glew andalready at that meeting they started to sketch plans for cooperationand for future practical workshops for students.It was 3 years ago and since then students of architecture had achance to participate in three workshops, each of them with adifferent character. During the first one in 2012, students had anopportunity to meet Prof Louis Nelson from the University of Virginiaand listen to his talk about the application of Lincolnshire methodsin America. In 2013, students got involved in a real renovationproject. That year, students had a chance to participate in intensiveworkshops at Tumby Moorside Barn, where five specialists introducedstudents to key aspects of building conservation. Despite being alisted building, the barn uniquely received a permission to holdworkshops there. It does not happen often that a listed building canbe experimented on, but thanks to this arrangement our students got areal insight into traditional details, which they could touch andrepair.
Hadrian's Wall and the defence of North Britain
Creators: name: Corby, Mark
Publisher: name: Archaeology Data Service
Year: 2019

description: Archaeologia Aeliana, 39, 9-13
description: The defence of North Britain is considered from the viewpoint of a modern army officer. Hadrian's Wall played only a minor role compared to that of the cavalry in the Advance Forts; the effectiveness of their patrols to the North of the Wall is stressed, in a strategy that relied upon reconnaissance, concentration and interception.
A Dolichenum at Vindolanda
Creators: name: Birley, Anthony R
name: Birley, Andrew
Publisher: name: Archaeology Data Service
Year: 2019

description: Archaeologia Aeliana, 39, 25-51
description: In 2009, two large alters were excavated side by side in the north-west quadrant of the third-century stone fort at Vindolanda, evidently inside a temple. A third, smaller altar was found just outside the temple. The relief on the main altar is a notable addition to the inscriptions and images of the Dolichenus cult in Britain. This article deals first with the excavation, then the alters, gives a brief account of the cult in general, with particular reference to Britain, and finally offers some reflections on the two cohorts.
Rapid and efficient one-pot microwave-assisted synthesis of 2-phenylimidazo[1,2-a]pyridines and 2-phenylimidazo[1,2-a]quinoline in water–PEG-400
Creators: name: Jadhav, Santosh A.
name: Shioorkar, Mahesh G.
name: Omprakash S. Chavan
name: Aniket P. Sarkate
name: Devanand B. Shinde
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: An effective, expeditious, environmentally benign one-pot synthesis of 2-phenylimidazo[1,2-a]pyridines and 2-phenylimidazo[1,2-a]quinoline from easily available starting materials as aromatic carbonyl compound, 2-amino pyridine, succinamide, and in situ generated α-iodo acetophenone in combination with green solvent PEG-400 and water (2:1) under microwave irradiation. The newly developed protocol with excellent yield of product in very short time of reaction by avoiding the use of lachrymatric α-chloro and α-bromocarbonyl compounds, volatile, toxic organic and hazardous solvents, reagents is the advantage of this research work. The final products were confirmed by their characterization data such as 1H NMR, 13C NMR, high resolution mass spectrometry (HRMS) and were compared with its reported method.
Bioactive molecule-based nano-particulate drug delivery system for antifertility activity
Creators: name: Khosla, Gayatri
name: Sharma, Vikram
name: Shukla, Vikesh Kumar
Publisher: name: Taylor & Francis
Year: 2024
Subjects: Biochemistry
Space Science
Medicine
Cell Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Current research work was design to develop bioactive molecule (Plumbagin) loaded nanoparticle formulation by using Design of experiment to investigate its formulation characteristics and in-vivo antifertility activity. Plumbagin belongs to the (Plumbaginaceae) family and mostly obtained from plant Plumbago indica Linn. Insolubility, instability and poor bioavailability are the factors which constrained in designing formulation of plumbagin. In order to overcome these factors, nanoparticles loaded plumbagin were formulated, this modified delivery system not only enhances the solubility and stability of plumbagin by reducing the particle size from thousands to a few hundred nanometers; when the size decreases, the active ingredient’s bioavailability increases. However, it also aids in enhancing the antifertility activity’s impact. Optimized formula was selected on the basis of design expert software and characterized. As a result, the optimized formula showed Particle size was 397.4 nm, shape of the nanoparticle was spherical detected by Scanning Electron Microscopy, Entrapment efficiency was 67.49 ± 0.047% and Zeta Potential was 25.0 mV. The disruption of the estrous cycle is indicated by the drop in FSH levels found in the in-vivo investigation. An in-vivo study reveals that the reproductive rate of albino wistar rats is decreasing. It was also discernible on the histology slide of the uterus and ovaries of the female albino rat. Follicle counts can yield valuable insights into the ovary’s functioning, particularly on the interplay between the mechanisms that control and facilitate folliculogenesis. At all test levels, no adverse symptoms were seen in any of the experimental groups after treatment. Due to high entrapment efficiency, stability, kinetics of release under simulated physiological conditions, and increased antifertility activity indicated that eudragit based nanoparticle formulation provide appropriate delivery system for Plumbagin.
Efficient Synthesis of (S,S)-2,8-diazabicyclo[4.3.0]nonane
Creators: name: Shipeng Chen
name: Dongqi Liu
name: Leilei Si
name: Ligong Chen
name: Xilong Yan
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: An efficient synthetic route for moxifloxacin chiral intermediate via five steps was established. Firstly, dehydration, N-acylation and cyclization were combined in one pot to meet the industrial requirement. Then relatively low hydrogen pressure was employed in the catalytic hydrogenation reaction with high yield. Isopropanol/water system was used in resolution which guaranteed high yield and perfect optical purity. The racemic process conducted by manganese dioxide and Pd/C successfully converted the undesired enantiomer into the racemate and hence the total yield increased remarkably. Furthermore, mild hydrogen transfer catalytic hydrogenation method was utilized in debenzylation process instead of high-pressure hydrogenation. Total yield of 39.0% was achieved which was much higher than that of 29.0% in literature.
Reaction of 4-hydroxycoumarin or its O-substituted derivatives with diatomic interhalogens: ICl and IBr
Creators: name: Popa, Marcel Mirel
name: Draghici, Constantin
name: Barbu, Loredana
name: Dumitrescu, Denisa E.
name: Dumitrascu, Florea
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Plant Biology

description: Herein, we present some aspects regarding the iodination/bromination of 4-hydroxycoumarin or its O-methyl or O-acetyl derivatives with iodine monochloride or iodine monobromide as halogenation reagents. Also, the investigation of photochemical transformation of the three 3-iodocoumarins was investigated for the first time.
A new approach to church archaeology, II: Dowsing and excavations at Ponteland and St. Oswald's, Durham
Creators: name: Bailey, Richard N
name: Cambridge, Eric
name: Briggs, H Denis
Publisher: name: Archaeology Data Service
Year: 2019

description: Archaeologia Aeliana, 13, 133-146
description: 'Dowsed' plans of 36 buildings compiled; test excavations of two churches confirmed the technique can recover otherwise inaccessible details. 'Imprint' phenomena also noted.
Bessie Surtees House Two Merchant Houses in Sandhill, Newcastle upon Tyne
Creators: name: Thomson, C
name: Heslop, David
name: McCombie, Grace
Publisher: name: Archaeology Data Service
Year: 2019

description: Archaeologia Aeliana, 22, 1-27
description: Details two houses, now amalgamated to form EH's Historic Properties Office and exhibition rooms. Their original fabric and documentary details of development and ownership are included.
Reaction of 4-hydroxycoumarin or its O-substituted Derivatives with Diatomic Interhalogens: ICl and IBr
Creators: name: Popa, Marcel Mirel
name: Draghici, Constantin
name: Barbu, Loredana
name: Dumitrescu, Denisa E.
name: Dumitrascu, Florea
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Plant Biology

description: Herein we present some aspects regarding the iodination/bromination of 4-hydroxycoumarin or its O-methyl or O-acetyl derivatives with iodine monochloride or iodine monobromide as halogenation reagents. Also the investigation of photochemical transformation of the three 3-iodocoumarins was investigated for the first time.
An Unenclosed Bronze Age House Site at Lookout Plantation, Northumberland
Creators: name: Monaghan, Jason
Publisher: name: Archaeology Data Service
Year: 2019

description: Archaeologia Aeliana, 22, 29-41
description: Reports a site uncovered during pipe-laying work and comprising an apparently heptagonal slot with a south west facing entrance and timber porch structure enclosing an inner ring of seven posts.
The electrocatalytic activity of pomelo peel-derived nitrogen-doped carbon material for oxygen reduction reaction
Creators: name: Yang, Jingjing
name: Zheng, Shengbiao
name: Tong, Wenjing
name: Zhang, Xiang
name: Tang, Jing
name: Guo, Jiahao
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Exploring the non-precious metal catalysts of oxygen reduction reaction (ORR) becomes the key to promote the industrialization of new energy devices such as fuel cells and metal-air batteries because of the sluggish kinetics of ORR. Three-dimensional N-doped carbon (NC-900) material was obtained using the high-temperature pyrolysis of pomelo peel waste. The prepared NC-900 catalyst possesses an ultra-high specific surface area of 1631.3 m2·g−1, high content of 57.7 ± 0.9% pyrrolic-N, and three-dimensional porous structure. As the ORR catalyst, NC-900 has a onset potential of 0.992 V and half-wave potential of 0.859 V, comparable to 0.988 and 0.872 V of Pt/C. The typical 4-electron pathway of ORR process is occupied by the surface of NC-900. The ORR catalytic activity of NC-900 was almost unaffected by methanol. After 8 h of continuous operation, the reduction current on the surface of NC-900 was decreased only 2.7% of the initial current. Based on these outstanding ORR performances, the pomelo peel-derived NC-900 can serve as a strong competitor for the substitute of Pt/C to promote the potential industrialization of new energy devices.
A Rapid an Efficient One Pot Microwave Assisted Synthesis of 2- Phenylimidazo[1,2-a]pyridines and 2-phenylimidazo[1,2-a]quinoline in Water-PEG-400
Creators: name: Jadhav, Santosh A.
name: Shioorkar, Mahesh G.
name: Omprakash S. Chavan
name: Aniket P. Sarkate
name: Devanand B. Shinde
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: Plant Biology

description: An effective, expeditious, environmentally benign and one pot synthesis of 2-Phenylimidazo[1,2-a] pyridines and 2-phenylimidazo[1,2-a] quinoline from easily available starting materials as aromatic carbonyl compound, 2-amino pyridine, Succinamide and in-situ generated α –iodo acetophenone in combination with green solvent PEG-400 and water (2:1) under microwave irradiation. The newly developed protocol with excellent yield of product in very short time of reaction by avoiding the use of lachrymatric α –chloro and α –bromocarbonyl compounds, volatile, toxic organic and hazardous solvents, reagents is the advantage of this research work. The final products were confirmed by their characterization data such as 1HNMR,13CNMR, HRMS and were compared with its reported method.
A survey of the Anglo-Saxon crypt at Hexham and its reused Roman stonework
Creators: name: Bidwell, Paul T
Publisher: name: Archaeology Data Service
Year: 2019

description: Archaeologia Aeliana, 39, 53-145
description: The Anglo-Saxon crypt at Hexham now lies below the nave of the Abbey. This article provides an in-depth account of the crypt, the fullest yet published, and the results of the first structural survey since one undertaken more than 120 years ago. An early history of the crypt, and its rediscovery and subsequent history until the 1880s, is provided; a background to the modern research is then given. The sources of the reused Roman stonework are described, and the survival and demolition of the Roman structures discussed. Roman and Medieval quarries and the quantities of stone required for the original church and other buildings at Hexham are also discussed. The details of the survey of the crypt are then presented. The construction of the crypt, possible antecedents to the ribbed vaults, the plaster surfaces and other features of the crypt are considered, before a concluding discussion of Roman ruins and Anglo-Saxon churches.
Reaction of 4-hydroxycoumarin or Its O-substituted derivatives with diatomic interhalogens: ICl and IBr
Creators: name: Popa, Marcel Mirel
name: Draghici, Constantin
name: Barbu, Loredana
name: Dumitrescu, Denisa E.
name: Dumitrascu, Florea
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Plant Biology

description: Herein, we present some aspects regarding the iodination/bromination of 4-hydroxycoumarin or its O-methyl or O-acetyl derivatives with iodine monochloride or iodine monobromide as halogenation reagents. Also, the investigation of photochemical transformation of the three 3-iodocoumarins was investigated for the first time.
An Excavation in the Roman Cemetery at South Shields
Creators: name: Snape, Margaret E
Publisher: name: Archaeology Data Service
Year: 2019

description: Archaeologia Aeliana, 22, 43-66
description: Several areas of use were revealed in a small area containing both cremations and inhumations. No unburnt bone survived because of the acidity of the soil, but gravegoods were found. There are separately authored reports on: `Pottery' by P T Bidwell (51--3); `Small finds' by A T Croom (53--63) including copper alloy, iron, and bone bracelets, copper alloy and iron rings, glass beads, jet objects, iron coffin fittings, copper alloy brooches, hobnails, a shale bracelet, millstone, and fragments of glass; and `Human remains' by J Langston (63).
The Early Medieval cemetery at the Castle, Newcastle upon Tyne
Creators: name: Harbottle, Barbara
name: Nolan, John
name: Vaughan, Jenny
Publisher: name: Archaeology Data Service
Year: 2019

description: Archaeologia Aeliana, 39, 147-287
description: This cemetery, which may have its origins in the late seventh century AD, overlies the remains of the Roman fort of Pons Aelius, occupying a headland site on the north bank of the River Tyne. In 1080 the 'New Castle upon Tyne' was constructed on the headland, reputed by some 12th-century chroniclers to have previously been the site of a Christian community called Monkchester. This report describes and discusses the results of the excavations of the cemetery, including the impact of the 'New Castle' and the later refortification. This is not considered to be a final or definitive statement on the cemetery, but does attempt to synthesis 13 seasons of excavation. Study of the skeletal remains is continuing and it is likely that the results of future analysis may revise some of the conclusions presented here. Similarly, the suggested presence of a late Saxon stone church, and a possible smaller predecessor, will almost certainly be a subject of further research and, perhaps, re-interpretation.
Water-mediated, green, and efficient synthesis of bisquinolones under catalyst-free conditions
Creators: name: Madhu, Bandi
name: Ch. Venkata Ramana Reddy
name: Dubey, Pramod Kumar
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Neuroscience
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Water-mediated, green, and efficient synthesis involving condensation of 4-hydroxy-1-methylquinoline-2(1H)-one (3) with different aromatic and heterocyclic aldehydes (4a–n) leading to 3,3′-(arylmethylene)-bis-(4-hydroxy-1-methylquinolin-2(1H)-one) 5(a–n) under catalyst-free conditions is described. This reaction has an easy workup without using column chromatography and provides excellent yields of the products in shorter reaction times. It does not require any catalyst and uses water as the medium which is the greenest solvent. 3 required in this work was itself obtained by condensation of N-methylaniline (1) with malonic acid (2) in the presence of POCl3 using a previously reported procedure.