cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Who is identified when screening for depression is undertaken in general practice? Baseline findings from the Diagnosis, Management and Outcomes of Depression in Primary Care (diamond) longitudinal study.
Creators: name: Gunn, Jane M.
name: Gilchrist, Gail P.
name: Chondros, Patty
name: Ramp, Melina
name: Hegarty, Kelsey L.
name: Blashki, Grant A.
name: Pond, Dimity C.
name: Kyrios, Michael
name: Herrman, Helen
Publisher: name: Swinburne
Year: 2024

description: Objectives: To report the baseline characteristics of the Diagnosis, Management and Outcomes of Depression in Primary Care (diamond) study cohort and discuss the implications for depression care in general practice. Design: A prospective longitudinal study beginning in January 2005. Participants and setting: Adult patients with depressive symptoms identified via screening with the Center for Epidemiologic Studies Depression Scale (CES-D >= 16) in 30 randomly selected Victorian general practices. Main outcome measure: Depression status on the Patient Health Questionnaire (PHQ). Results: 789 patients form the cohort (71 % women). At baseline, 47% were married, 21 % lived alone, 36% received a pension or benefit, 15% were unable to work, 23% reported hazardous drinking, 32% were smokers, 39% used antidepressants and 19% used sedatives. 27% satisfied criteria for current major depressive syndrome (MDS) on the PHQ, while 52% had 'persistent' depressive symptoms, and 22% had 'transient' depressive symptoms, lasting at most a few weeks. Of those satisfying criteria for MDS, 49% were also classified with an anxiety syndrome, 40% reported childhood sexual abuse, 57% reported childhood physical abuse, 42% had at some time been afraid of their partner, and 72% reported a chronic physical condition; 84% were receiving mental health care (either taking antidepressants or seeing a health practitioner specifically for mental health care) compared with 66% of those with persistent depressive symptoms and 57% with transient depressive symptoms. Conclusion: This method of screening for depressive symptoms in general practice identifies a group of patients with substantial multiple comorbidities - psychiatric, physical and social problems coexist with depressive symptoms, raising challenges for the management of depression in general practice.
Ophion callanderi JOHANSSON 2019
Creators: name: Riedel
name: Pénigot
name: Schwarz
name: Diller
name: Johansson
name: Japoshvili, G.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Ichneumonidae
Ophion
Ophion callanderi

description: Ophion callanderi JOHANSSON, 2019
M a t e r i a l e x a m i n e d: 1♀ 27.vii.-10.viii., 1♀ 24.viii.-7.ix., 1♀ 21.ix.-5.x.
D i s t r i b u t i o n: Western Palaearctic, new record for Georgia and the Caucasus region.
description: Published as part of Riedel, Pénigot, Schwarz, Diller, Johansson & Japoshvili, G., 2023, Darwin wasps (Hymenoptera, Ichneumonidae) of the Kintrishi National Park, Sakartvelo (Georgia), with descriptions of six new species, pp. 61-153 in Linzer biologische Beiträge 55 (1) on page 115, DOI: 10.5281/zenodo.10788481
Formica yessensis WHEELER 1913
Creators: name: Seifert, Bernhard
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Formica
Formica yessensis

description:  Formica yessensis WHEELER, 1913 Formica truncorum var. yessensis WHEELER, 1913 [type investigation] The taxon was described by FOREL (1901) under the infrasubspecific name Formica rufa r. truncorum var. yessensis FOREL, 1901 from Sorachi, some 100 km ENE of Sapporo, Hokaido. Investigated was one type worker from MHN Genève labelled by A. Forel “ Formica truncicola v. yessensis For Type ” and carrying a printed label “Sorachi Prov. Ishikari Yesso V. 1899. Mus.em. 24.XI.1899 ”. The specimen shows below average setae length on eyes and no setae on dorsum of scape, and extensor profile of hind tibia but is in any character within the range of variation known from the Palaearctic population of F. truncorum. For a more detailed argumentation in favor of this synonymization, see below under taxonomic comments.
description: Published as part of Seifert, Bernhard, 2021, A taxonomic revision of the Palaearctic members of the Formica rufa group (Hymenoptera: Formicidae) - the famous mound-building red wood ants, pp. 133-179 in Myrmecological News 31 on page 169, DOI: 10.25849/myrmecol.news_031:133, http://zenodo.org/record/5582216
description: {"references": ["WHEELER, W. M. 1913: A revision of the ants of the genus Formica (LINNE) MAYR. - Bulletin of the Museum of Comparative Zoology 53: 379 - 565.", "FOREL, A. 1901: Formiciden des Naturhistorischen Museums zu Hamburg. Neue Calyptomyrmex -, Dacryon -, Podomyrma - und Echinopla - Arten. - Mitteilungen aus dem Naturhistorischen Museum in Hamburg 18: 43 - 82."]}
Media richness and user acceptance of second life
Creators: name: Saeed, Nauman
name: Yang, Yun
name: Sukunesan, Suku
Publisher: name: Swinburne
Year: 2024

description: Second Life is a 3-D multi user virtual environment and is used as a platform for education by many institutions around the world. It offers a variety of communication channels to perform academic activities for both distance and on-campus education. As such, Second Life provides an excellent platform to test the implications of media richness theory (MRT). This paper aims at examining the media richness of Second Life and its impact on the user acceptance. Media Richness Theory and Technology Acceptance Model have been used as its theoretical basis. PLS approach is used to test the hypothesised relationships. Our study results suggest that Second Life is highly rich medium and is capable of promoting effective communication among its users. We found that media richness has a direct positive effect on the perceived usefulness and perceived ease of use of Second Life which in turn leads to actual usage. Some implications of our findings are discussed and ideas for future research are also presented.
title: Head-related transfer functions calculated using the boundary element method for a head and torso simulator
Creators: name: Thulke, Mirko
Publisher: name: University of Liverpool Repository
Year: 2016

description: The work reported in this thesis focuses on the calculation of the head-related transfer functions (HRTF) using the boundary element method (BEM). The main aim is to investigate the potential in using boundary element methods to predict HRTFs for sound sources that are close to the human body. To assess the accuracy of BEM using SYSNOISE software, results from direct and indirect BEM have been compared to an analytical solution of a rigid sphere. These typically show close agreement between 100 Hz and at least 3 kHz. However, at higher frequencies, the non-uniqueness of the BEM solutions leads to irregular frequencies, which become a major source of error. To try and identify and reduce these errors, procedures were developed that could be used for BEM modelling of the head and torso simulator (HATS) for which no analytical model is available. The second part of the work focused on the creation of a three-dimensional model of a HATS for the BEM simulation. A laser scan of the HATS was imported into PRO-ENGINEER software but the complexity of the geometrical features of the ear required additional editing using BLENDER software. The final model was successfully meshed and imported into SYSNOISE. BEM simulations were used to calculate sound fields over the surface on the HATS between 500 Hz and 10 kHz for a point source that was 1 m in front of the HATS and two point source positions that were close to the side of the torso. This allowed visual confirmation of features such as the bright spot at the back of the head and pinna resonances. HRTFs from the BEM model were validated against measurements on the HATS in the anechoic chamber and, in general, close agreement was achieved between 500 Hz and 8 kHz. At 10 kHz, the discrepancy is attributed to irregular frequencies.
The effectiveness of Stress Management Programs for Educators: A Scoping Review Protocol
Creators: name: Faria, Carolina Dias
Publisher: name: OSF Registries
Year: 2024
Subjects: subject: Medicine and Health Sciences
subject: Rehabilitation and Therapy
subject: Mental and Social Health
subject: Social and Behavioral Sciences

description: Occupational stress has a negative impact on the mental health of educators, which results in repercussions on the functionality and occupational performance of each one, directly compromising the education of future young people. The identified programs focus on the development of effective strategies for managing occupational stress for educators from primary school to and including higher education. The Scoping Review seeks to verify gaps that exist and thus identify occupational stress management programs orientated at educators, as well as their effectiveness and recognize intervention strategies to reduce occupational stress in educators. This Scoping Review will be guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) and will follow the methodology recommended by the Joanna Briggs Institute (JBI) Manual for Evidence Synthesis. It is proposed the inclusion of peer-reviewed studies, published in English and Portuguese in the PubMed and B-on databases.
Ophion crassicornis BROCK 1982
Creators: name: Riedel
name: Pénigot
name: Schwarz
name: Diller
name: Johansson
name: Japoshvili, G.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Ichneumonidae
Ophion
Ophion crassicornis

description: Ophion crassicornis BROCK, 1982
M a t e r i a l e x a m i n e d: Trap4:1♁20.v.-1.vi.
D i s t r i b u t i o n: Western Palaearctic, new record for Georgia and the Caucasus region.
description: Published as part of Riedel, Pénigot, Schwarz, Diller, Johansson & Japoshvili, G., 2023, Darwin wasps (Hymenoptera, Ichneumonidae) of the Kintrishi National Park, Sakartvelo (Georgia), with descriptions of six new species, pp. 61-153 in Linzer biologische Beiträge 55 (1) on page 115, DOI: 10.5281/zenodo.10788481
Cyclin-dependent kinase regulatory subunit 1 promotes cell proliferation by insulin regulation
Creators: name: Liu, Chun-Yan
name: Zhao, Wen-Li
name: Wang, Jin-Xing
name: Zhao, Xiao-Fan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Computational Biology

description: Cyclin-dependent kinase regulatory subunit 1 (CKS1) helps regulate the cell cycle to increase cell number. However, the hormonal regulation on CKS1 expression is not well understood. We report that CKS1 is involved in the promotion of cell proliferation with insulin regulation in the lepidopteran insect Helicoverpa armigera. CKS1 is expressed in various tissues during the larval feeding stage. CKS1 knockdown results in larval death, body weight decrease, pupation time delay, and small-sized pupa formation. The underlying mechanism involves the blocking of cell proliferation and the repression of gene expression in the insulin pathway after CKS1 knockdown. CKS1 overexpression in the epidermal cell line results in cell proliferation. The N45 amino acid asparagine in the CKS domain is essential for the function of CKS in cell proliferation. CKS1 is upregulated by insulin via an insulin receptor, but is repressed by a high level of steroid hormone 20-hydroxyecdysone (20E). Results suggest that CKS1 promotes cell proliferation and body growth in coordination with the regulatory actions of insulin and steroid hormone 20E.
Using learning styles and preferences to incorporate emerging e-learning tools in teaching
Creators: name: Saeed, Nauman
name: Yang, Yun
Publisher: name: Swinburne
Year: 2024

description: Emerging e-learning tools have the potential to enrich academic environments. However, there is a need to understand the requirements, expectations, and learning styles of the end users before incorporating new tools into courses. This paper presents details of a user study to analyze learning styles and tools preferences of the end users and to explore significant relationships among them. The study outcomes highlight several significant relationships and reveal the tools preferences of various learner types. In contrast with existing studies, our study report balanced or unbiased academic performances across all learner types.
Efficient Protocol for Synthesis of Pyrazolo[3,4-a]acridines
Creators: name: Satheeshkumar, Rajendran
name: Kaminsky, Werner
name: Sparkes, Hazel A.
name: Prasad, Karnam Jayarampillai Rajendra
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Cell Biology
subject: Physics
subject: Biochemistry
subject: Biophysics

description: A new class of pyrazolo[3,4-a]acridines have been prepared. The synthon acridones were obtained in very good yield by a one-pot reaction of 2-amino-5-chloro or nitro substituted benzophenones with 1,3-cyclic diketones in the presence of freshly prepared Eaton’s reagent without solvent, using Friedländer synthesis. The intermediates were reacted with ethylformate followed by hydrazine hydrate to afford pyrazolo[3,4-a]acridines. All of the compounds were purified by recrystallization only, and no chromatographic workup was required. The structures of the synthesized compounds were deduced by spectroscopic techniques, including single-crystal x-ray diffraction.
Ophion confusus JOHANSSON 2019
Creators: name: Riedel
name: Pénigot
name: Schwarz
name: Diller
name: Johansson
name: Japoshvili, G.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Ichneumonidae
Ophion
Ophion confusus

description: Ophion confusus JOHANSSON, 2019
M a t e r i a l e x a m i n e d: Trap4: 1♀ 15-29.vi.
D i s t r i b u t i o n: Western Palaearctic, new record for Georgia and the Caucasus region.
description: Published as part of Riedel, Pénigot, Schwarz, Diller, Johansson & Japoshvili, G., 2023, Darwin wasps (Hymenoptera, Ichneumonidae) of the Kintrishi National Park, Sakartvelo (Georgia), with descriptions of six new species, pp. 61-153 in Linzer biologische Beiträge 55 (1) on page 115, DOI: 10.5281/zenodo.10788481
Dicamba and 2,4-D residues following applicator cleanout: A potential point source to the environment and worker exposure
Creators: name: Osborne, Penny P.
name: Zichun Xu
name: Swanson, Kenneth D.
name: Thia Walker
name: Farmer, Delphine K.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Pharmacology
subject: Science Policy
subject: Cancer
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Engineering
subject: Biochemistry
subject: Biophysics

description: This paper presents a survey of pesticide residues in tanks following application and throughout the cleanout procedure as conducted by 46 volunteer operators across Colorado. While many pesticides were detected, this paper focuses on dicamba and 2,4-D, which were detected by liquid chromatography/tandem mass spectroscopy (LC-MS/MS). An exponential decrease in concentration was observed with sequential rinses, although this decrease may be more rapid for more water-soluble pesticides. More than 95% of the pesticide in the prerinse solution was removed by the end of the third rinse in all but three operator samples. Concentrations after three rinses were 0.41 ± 0.25 and 3.3 ± 1.1 mg/L for dicamba and 2,4-D, respectively. These concentrations suggest that the recommended practice of three rinses may not be adequate to eliminate off-target effects or point sources of pesticide waste, and that the recommended standard of personal protective equipment is essential to prevent worker exposure to the chemicals.Implications: This paper demonstrates that the waste generated during cleanout of pesticide application devices constitutes a potential source of pollution and worker exposure. In particular, while the first rinse of pesticide containers is often treated as hazardous waste and reapplied to crops, the remaining rinses are not. This work demonstrates that the wastewater generated in subsequent rinses can have high enough concentrations to impact worker health, cause off-target effects on crops, and potentially constitute a point source of pesticides. The practical implication is for improved recommendations and regulations regarding pesticide applicators and their cleanout process.
MONITORING AND CONTROL SYSTEMS FOR INFORMATION SECURITY: ENHANCING CYBER DEFENSE
Creators: name: Mardona Omonboyeva  Nigora Normatova  Odamboy Jabbarov
Publisher: name: Zenodo
Year: 2024

description: Monitoring and control systems are essential components of modern information security frameworks, providing real-time oversight and mitigation of potential cyber threats. This article explores the significance of monitoring and control systems in safeguarding digital assets, their key components, importance, challenges, and considerations. In today's digital age, where information is a valuable asset, protecting it from unauthorized access, misuse, and theft is paramount. As organizations increasingly rely on digital platforms to conduct business, the importance of robust information security measures cannot be overstated. Among the array of strategies and technologies available, monitoring and control systems play a crucial role in safeguarding sensitive data and ensuring the integrity of digital infrastructure.
Ophion scutellaris THOMSON 1888
Creators: name: Riedel
name: Pénigot
name: Schwarz
name: Diller
name: Johansson
name: Japoshvili, G.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Ichneumonidae
Ophion
Ophion scutellaris

description: Ophion scutellaris THOMSON, 1888
M a t e r i a l e x a m i n e d: Trap 2: 2♀♀ 20.iv.-5.v.
D i s t r i b u t i o n: Transpalaearctic, new record for Georgia nd the Caucasus region.
description: Published as part of Riedel, Pénigot, Schwarz, Diller, Johansson & Japoshvili, G., 2023, Darwin wasps (Hymenoptera, Ichneumonidae) of the Kintrishi National Park, Sakartvelo (Georgia), with descriptions of six new species, pp. 61-153 in Linzer biologische Beiträge 55 (1) on page 115, DOI: 10.5281/zenodo.10788481
title: Structure-borne sound transmission on frameworks of beams
Creators: name: Wang, Xing
Publisher: name: University of Liverpool Repository
Year: 2016

description: Many engineering structures are built from frameworks of beams, particularly lightweight structures. For the purpose of noise control from airborne and structure-borne sources, it is useful to be able to predict vibration transmission across these frameworks. This thesis investigates the potential use of Advanced Statistical Energy Analysis (ASEA) to predict structure-borne sound transmission when the beams support multiple wave types due to wave conversion at the junction. In contrast to Statistical Energy Analysis (SEA), ASEA is able to account for high propagation losses and indirect coupling through the use of ray tracing. SEA and ASEA were validated through comparison with measurements and numerical experiments with Finite Element Methods (FEM). When each beam supports at least two local modes for each wave type in the frequency band of interest and the modal overlap factor is at least 0.1, FEM and measurement data tend to have average values which form smooth curves such as those predicted by SEA and ASEA. It was shown that SEA and ASEA models could incorporate Euler-Bernoulli and Timoshenko theory by changing over from Euler-Bernoulli to Timoshenko group velocity when calculating the coupling loss factors. However, comparisons with measurements were not conclusive although there were indications that a suitable crossover frequency could be when Timoshenko and Euler-Bernoulli group velocities differ by at least 26%. Agreement between FEM and ASEA indicates that it is appropriate to ignore phase effects in the ray tracing approach used with ASEA. This was particularly noteworthy for the three-bay and five-bay truss beams as these were perfectly periodic for which phase effects could be important. Results for an L-junction, a rectangular beam frame and a five-bay truss with relatively long beams and relatively high internal loss factors demonstrated that ASEA was able to incorporate high propagation losses. This was not possible with SEA. For a three-bay truss beam with relatively short beams ASEA showed close agreement with FEM and measurements confirming that there was significant indirect coupling rather than high propagation losses. There are indications from the five-bay truss beams that ASEA may no longer be accurate in predicting the response on beams that are at least three structural junctions away from the source beam, particularly when ASEA predicts high propagation losses on the receiving beam.
An Efficient Protocol for Synthesis of Pyrazolo[3,4-a]acridines
Creators: name: Satheeshkumar, Rajendran
name: Kaminsky, Werner
name: Sparkes, Hazel A.
name: Prasad, Karnam Jayarampillai Rajendra
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Cell Biology
subject: Physics
subject: Biochemistry
subject: Biophysics

description: A new class of pyrazolo[3,4-a]acridines have been prepared, the synthon acridones were obtained in very good yield by one pot reaction of 2-amino-5-chloro or nitro substituted benzophenones with 1,3-cyclic diketones in the presence of freshly prepared Eaton's reagent without solvent, using Friedländer synthesis. The intermediates were reacted with ethylformate followed by hydrazine hydrate to afford pyrazolo[3,4-a]acridines. All of the compounds were purified by recrystallization only, and no chromatographic work-up was required. The structures of the synthesized compounds were deduced by spectroscopic techniques, including single crystal X-ray diffraction.
Ophion tenuicornis JOHANSSON 2019
Creators: name: Riedel
name: Pénigot
name: Schwarz
name: Diller
name: Johansson
name: Japoshvili, G.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Ichneumonidae
Ophion
Ophion tenuicornis

description: Ophion tenuicornis JOHANSSON, 2019
M a t e r i a l e x a m i n e d: Trap 2: 1♀ 27.vii.-10.viii.; trap 4: 2♀♀ 27.vii.-10.viii., 1♀ 10- 24.viii., 1♀ 24.viii.-7.ix., 1♀ 7-21.ix., 1♀ 21.ix.-5.x.
D i s t r i b u t i o n: Western Palaearctic, new record for Georgia and the Caucasus region.
description: Published as part of Riedel, Pénigot, Schwarz, Diller, Johansson & Japoshvili, G., 2023, Darwin wasps (Hymenoptera, Ichneumonidae) of the Kintrishi National Park, Sakartvelo (Georgia), with descriptions of six new species, pp. 61-153 in Linzer biologische Beiträge 55 (1) on page 115, DOI: 10.5281/zenodo.10788481
A conceptual framework for unified and comprehensive SOA management
Creators: name: Mueller, Ingo
name: Han, Jun
name: Schneider, Jean-Guy
name: Versteeg, Steven
Publisher: name: Swinburne
Year: 2024

description: Business requirements, such as regulations and laws, corporate policies, quality of service aspects, etc. affect the management of enterprise-scale SOA systems during different life-cycle stages. Such requirements also induce interdependencies across different elements and aspects of an SOA system. Therefore, a systematic approach to SOA management must be in place in order to effectively govern the development and execution of automated business processes throughout the entire SOA life-cycle in compliance with business requirements. Until now, industry and research have focused on specific management aspects rather than unified and comprehensive solutions. This paper addresses this issue by proposing a conceptual framework for SOA management that combines a micro-kernel/plug-in architecture with the concept of management workflows. The micro-kernel incorporates a unified registry/repository model, facilitating the extension of specific management capabilities with plug-ins. Management workflows compose the capabilities of multiple plug-ins into comprehensive management processes that can be linked to events in different places in an SOA system.
Dicamba and 2,4-D residues following applicator clean-out: A potential point source to the environment and worker exposure
Creators: name: Osborne, Penny P.
name: Zichun Xu
name: Swanson, Kenneth D.
name: Thia Walker
name: Farmer, Delphine K.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Pharmacology
subject: Science Policy
subject: Cancer
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Engineering
subject: Biochemistry
subject: Biophysics

description: This paper presents a survey of pesticide residues in tanks following application and throughout the clean-out procedure as conducted by 46 volunteer operators across Colorado. While many pesticides were detected, this paper focuses on dicamba and 2,4-D, which were detected by LC-MS/MS. An exponential decrease in concentration was observed with sequential rinses, although this decrease may be more rapid for more water soluble pesticides. Over 95% of the pesticide in the pre-rinse solution was removed by the end of the third rinse in all but three operator samples. Concentrations after three rinses were 0.41 ± 0.25 and 3.3 ± 1.1 mg/L for dicamba and 2,4-D, respectively. These concentrations suggest that the recommended practice of three rinses may not be adequate to eliminate off-target effects or point sources of pesticide waste, and that the recommended standard of personal protective equipment is essential to prevent worker exposure to the chemicals. Implications StatementThis paper demonstrates that the waste generated during cleanout of pesticide application devices constitutes a potential source of pollution and worker exposure. In particular, while the first rinse of pesticide containers is often treated as hazardous waste and reapplied to crops, the remaining rinses are not. This work demonstrates that the wastewater generated in subsequent rinses can have high enough concentrations to impact worker health, cause off-target effects on crops and potentially constitute a point source of pesticides. The practical implication is for improved recommendations and regulations regarding pesticide applicators and their cleanout process.
Cyclin-dependent kinase regulatory subunit 1 promotes cell proliferation by insulin regulation
Creators: name: Liu, Chun-Yan
name: Zhao, Wen-Li
name: Wang, Jin-Xing
name: Zhao, Xiao-Fan
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Computational Biology
subject: Cancer
subject: Developmental Biology
subject: Biological Sciences
subject: Chemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Biochemistry

description: Cyclin-dependent kinase regulatory subunit 1 (CKS1) helps regulate the cell cycle to increase cell number. However, the hormonal regulation on CKS1 expression is not well understood. We report that CKS1 is involved in the promotion of cell proliferation with insulin regulation in the lepidopteran insect Helicoverpa armigera. CKS1 is expressed in various tissues during the larval feeding stage. CKS1 knockdown results in larval death, body weight decrease, pupation time delay, and small-sized pupa formation. The underlying mechanism involves the blocking of cell proliferation and the repression of gene expression in the insulin pathway after CKS1 knockdown. CKS1 overexpression in the epidermal cell line results in cell proliferation. The N45 amino acid asparagine in the CKS domain is essential for the function of CKS in cell proliferation. CKS1 is upregulated by insulin via an insulin receptor, but is repressed by a high level of steroid hormone 20-hydroxyecdysone (20E). Results suggest that CKS1 promotes cell proliferation and body growth in coordination with the regulatory actions of insulin and steroid hormone 20E.
Stauropoctonus bombycivorus
Creators: name: Riedel
name: Pénigot
name: Schwarz
name: Diller
name: Johansson
name: Japoshvili, G.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Ichneumonidae
Stauropoctonus
Stauropoctonus bombycivorus

description: Stauropoctonus bombycivorus (GRAVENHORST, 1829)
M a t e r i a l e x a m i n e d: Trap 15: 1♁ 30.vi.-14.vii., 1♁ 14-28.vii.
D i s t r i b u t i o n: Transpalaearctic and Oriental, known from Georgia (DJANELIDZE 1967; KASPARYAN & KHALAIM 2007).
description: Published as part of Riedel, Pénigot, Schwarz, Diller, Johansson & Japoshvili, G., 2023, Darwin wasps (Hymenoptera, Ichneumonidae) of the Kintrishi National Park, Sakartvelo (Georgia), with descriptions of six new species, pp. 61-153 in Linzer biologische Beiträge 55 (1) on page 115, DOI: 10.5281/zenodo.10788481
Investigation on critical structural motifs of ligands for triggering glucocorticoid receptor nuclear migration through molecular docking simulations
Creators: name: Liu, Ya-Lin
name: Soonmin Jang
name: Shih-Min Wang
name: Chiu-Hao Chen
name: Feng-Yin Li
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: Hematology

description: The glucocorticoid receptor (GR), a transcription factor regulating gene expression in a ligand-dependent fashion, is known for flexibility in adapting various ligands with their structures ranging from steroid to non-steroid. However, in our previous study, GR shows a stringent discrimination against a set of steroid ligands with highly similar structures for triggering its nuclear migration. In order to resolve this puzzle, we employed molecular docking simulations to investigate the origin of this structural discrimination. By analyzing the docking orientations and the related ligand–GR interaction patterns, we found that the hydrophilicity mismatch between the docking ligand and the GR ligand-binding site is the main cause combined with the steric hindrance and structural rigidness of these steroid ligands. Furthermore, we utilized this knowledge to rationalize how the structure–binding interaction of non-steroid ligands triggers GR nuclear migration with their structures available in Protein Data Bank.
The form of the asymptotic depth-limited wind-wave spectrum. Part II - The wavenumber spectrum
Creators: name: Young, I. R.
name: Babanin, Alexander
Publisher: name: Swinburne
Year: 2024

description: Data from a spatial array of wave gauges is analysed using the Wavelet Directional Method (WDM) to directly determine the wavenumber spectrum. The data shows that the asymptotic depth-limited wavenumber spectrum can be represented as a two-parameter form, which is far simpler than the corresponding frequency spectrum. The WDM analysis shows that there are significant nonlinear processes active in the finite depth water, which results in energy being 'smeared' across a range of wavenumbers and frequencies around the standard dispersion shell. As a result, the wavenumber spectrum has much less peak enhancement than seen in the frequency spectrum obtained with standard Fourier analysis. In addition, the wavenumber spectrum does not have the clear harmonic previously observed in the finite depth frequency spectrum. This result demonstrates that the harmonic is nonlinearly phase-locked to the spectral peak.
title: John Stuart Mill and romanticism
Creators: name: Macleod, Christopher
Publisher: name: University of St Andrews
publisherIdentifier: https://ror.org/02wn5qz54
publisherIdentifierScheme: ROR
Year: 2011

description: This thesis is an examination of the philosophy of John Stuart Mill and its relation to the romantic movement. The Introduction outlines reasons to believe that such an inquiry is sensible: Mill’s readings of the British and German romantics are outlined. I proceed to offer an argument for the application of an historical term such as ‘romanticism’ in philosophy and suggest that the space opened up by the revisionist view of romanticism as an extension, rather than a denial, of the Enlightenment project creates room to take seriously Mill’s relation to the romantic movement. Chapters 1-4 are concerned with Mill’s metanormative theory. For Mill, the norms of acting and believing are founded on the assent given to our primitive dispositions under critical scrutiny. I investigate this foundation in the context of Mill’s denial of normative validity to intuitions. The relation of Mill’s metanormative theory to romanticism is taken up during the process of interpretation. The movement shows broad endorsement of what I term ‘romantic-cognitivism’ – the post-Kantian view that we can arrive at truth through the process of ‘creative-discovery’. I hold that Mill’s metanormative theory is not so far away from romantic-cognitivism in orientation as might be thought. I turn to Mill’s macro-epistemology and conception of mind in Chapter 5. Mill’s view of how we come to know, I suggest, moves towards a Coleridgean position – Mill sees the mind as active, and holds that we come to possess a deeper state of knowledge by engaging with propositions actively. In Chapter 6, I consider Mill’s philosophy of history. Many have noted that Mill endorses a directional theory of historical progress. I argue that he also adopts ‘hermeneutical historicism’ in his discussions of history. In Chapter 7, I consider Mill’s theory of human nature. Mill believes that human nature is malleable: it is subject to change and emendation.
Comparison of allocation strategies of convalescent plasma to reduce excess infections and mortality from SARS-CoV-2 in a US-like population
Creators: name: Wesolowski, A
name: Vassallo, R.R
name: Lessler, J
name: Truelove, S
name: Bravo, M.D
name: Lau, B
name: Drabo, E.F
name: Casadevall, A
name: Yenokyan, K
name: Tobian, A.A.R
name: Kostandova, N
name: Bloch, E.M
Publisher: name: John Wiley and Sons Inc
Year: 2023

description: Background: While the use of convalescent plasma (CP) in the ongoing COVID-19 pandemic has been inconsistent, CP has the potential to reduce excess morbidity and mortality in future pandemics. Given constraints on CP supply, decisions surrounding the allocation of CP must be made. Study Design and Methods: Using a discrete-time stochastic compartmental model, we simulated implementation of four potential allocation strategies: administering CP to individuals in early hospitalization with COVID-19; administering CP to individuals in outpatient settings; administering CP to hospitalized individuals and administering any remaining CP to outpatient individuals and administering CP in both settings while prioritizing outpatient individuals. We examined the final size of SARS-CoV-2 infections, peak and cumulative hospitalizations, and cumulative deaths under each of the allocation scenarios over a 180-day period. We compared the cost per weighted health benefit under each strategy. Results: Prioritizing administration to patients in early hospitalization, with remaining plasma administered in outpatient settings, resulted in the highest reduction in mortality, averting on average 15% more COVID-19 deaths than administering to hospitalized individuals alone (95% CI [11%–18%]). Prioritizing administration to outpatients, with remaining plasma administered to hospitalized individuals, had the highest percentage of hospitalizations averted (22% [21%–23%] higher than administering to hospitalized individuals alone). Discussion: Convalescent plasma allocation strategy should be determined by the relative priority of averting deaths, infections, or hospitalizations. Under conditions considered, mixed allocation strategies (allocating CP to both outpatient and hospitalized individuals) resulted in a larger percentage of infections and deaths averted than administering CP in a single setting.
Investigation on critical structural motifs of ligands for triggering glucocorticoid receptor nuclear migration through molecular docking simulations
Creators: name: Liu, Ya-Lin
name: Soonmin Jang
name: Shih-Min Wang
name: Chiu-Hao Chen
name: Feng-Yin Li
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Molecular Biology
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: The glucocorticoid receptor (GR), a transcription factor regulating gene expression in a ligand-dependent fashion, is known for flexibility in adapting various ligands with their structures ranging from steroid to non-steroid. However, in our previous study (Chen et al., 2011), GR shows a stringent discrimination against a set of steroid ligands with highly similar structures for triggering its nuclear migration. In order to resolve this puzzle, we employed molecular docking simulations to investigate the origin of this structural discrimination. By analyzing the docking orientations and the related ligand-GR interaction patterns, we found that the hydrophilicity mismatch between the docking ligand and the GR ligand-binding site is the main cause combined with the steric hindrance and structural rigidness of these steroid ligands. Furthermore we utilized this knowledge to rationalize how the structure-binding interaction of non-steroid ligands triggers GR nuclear migration with their structures available in Protein Data Bank.
Incidence and molecular characterization of flavescence dorée and stolbur phytoplasmas in grapevine cultivars from different viticultural areas of Serbia
Creators: name: Kuzmanovic, S.
name: Martini, M.
name: Ermacora, P.
name: Ferrini, F.
name: Starović, M.
name: Tosić, M.
name: Carraro, L.
name: Osler, R.
Publisher: name: VITIS - Journal of Grapevine Research
Year: 2015

description: The presence and distribution of grapevine phytoplasmas was investigated from 2003 to 2005 in some of the most important viticultural areas of Serbia, considering in particular the susceptibility and sensitiveness of both local and imported grapevine cultivars. Both flavescence dorée (FD) and bois noir (BN) phytoplasmas were detected using molecular techniques. The presence of FD phytoplasma at the moment seems limited, while BN phytoplasma appears to be present in the majority of grape growing regions in Serbia. Field surveys demonstrate that grapevine yellows (GY) epidemics in the vineyards inspected in Serbia spread very fast, indeed the incidence of symptomatic plants increased considerably year by year. In particular, the average rate of FD diffusion increased from 45.5 to 93.0 % in the Sićevačko region, while the spread of BN resulted lower. The local cultivar 'Plovdina' appeared to be extremely sensitive to FD phytoplasma showing a percentage of infected plants ranging from 91 to 100 %. PCR-RFLP and phylogenetic analyses based on ribosomal protein (rp) and secY gene sequences performed on Serbian FD grapevine strains demonstrated their close relationship with the Italian FD-C strain present in north-east Italy. Based on both phylogenetic markers, Serbian FD strains represent a new distinct lineage and together with the FD-C strain form a major phylogenetic group within the elm yellows group.
description: VITIS - Journal of Grapevine Research, Vol. 47 No. 2 (2008): Vitis
Accounting for assay performance when estimating the temporal dynamics in SARS-CoV-2 seroprevalence in the U.S.
Creators: name: Lessler, J
name: Slayton, R.B
name: Johansson, M.A
name: Healy, J.M
name: Biggerstaff, M
name: García-Carreras, B
name: Huang, A.T
name: Quandelacy, T
name: Hitchings, M.D.T
name: Cummings, D.A.T
name: Salje, H
Publisher: name: Nature Research
Year: 2023

description: Reconstructing the incidence of SARS-CoV-2 infection is central to understanding the state of the pandemic. Seroprevalence studies are often used to assess cumulative infections as they can identify asymptomatic infection. Since July 2020, commercial laboratories have conducted nationwide serosurveys for the U.S. CDC. They employed three assays, with different sensitivities and specificities, potentially introducing biases in seroprevalence estimates. Using models, we show that accounting for assays explains some of the observed state-to-state variation in seroprevalence, and when integrating case and death surveillance data, we show that when using the Abbott assay, estimates of proportions infected can differ substantially from seroprevalence estimates. We also found that states with higher proportions infected (before or after vaccination) had lower vaccination coverages, a pattern corroborated using a separate dataset. Finally, to understand vaccination rates relative to the increase in cases, we estimated the proportions of the population that received a vaccine prior to infection.
Structural modeling and molecular simulation analysis of HvAP2/EREBP from barley
Creators: name: Pandey, Bharati
name: Sharma, Pradeep
name: Chetna Tyagi
name: Sukriti Goyal
name: Abhinav Grover
name: Sharma, Indu
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Computational Biology

description: AP2/ERF transcription factors play a critical role in plant development and stress adaptation. This study reports the three-dimensional ab initio-based model of AP2/EREBP protein of barley and its interaction with DNA. Full-length coding sequence of HvAP2/EREBP gene isolated from two Indian barley cultivars, RD 2503 and RD 31, was used to model the protein. Of five protein models obtained, the one with lowest C-score was chosen for further analysis. The N- and C-terminal regions of HvAP2 protein were found to be highly disordered. The dynamic properties of AP2/EREBP and its interaction with DNA were investigated by molecular dynamics simulation. Analysis of trajectories from simulation yielded the equilibrated conformation between 2-10ns for protein and 7-15ns for protein-DNA complex. We established relationship between DNA having GCC box and DNA-binding domain of HvAP2/EREBP was established by modeling 11-base-pair-long nucleotide sequence and HvAP2/EREBP protein using ab initio method. Analysis of protein–DNA interaction showed that a β-sheet motif constituting amino acid residues THR105, ARG100, ARG93, and ARG83 seems to play important role in stabilizing the complex as they form strong hydrogen bond interactions with the DNA motif. Taken together, this study provides first-hand comprehensive information detailing structural conformation and interactions of HvAP2/EREBP proteins in barley. The study intensifies the role of computational approaches for preliminary examination of unknown proteins in the absence of experimental information. It also provides molecular insight into protein–DNA binding for understanding and enhancing abiotic stress resistance for improving the water use efficiency in crop plants.
Modelling interventions and contact networks to reduce the spread of carbapenem-resistant organisms between individuals in the ICU
Creators: name: Martínez, D.A
name: Levin, S.R
name: Paul, R
name: Cai, J
name: Toerper, M
name: Goodman, K.E
name: Milstone, A.M
name: Simner, P.J
name: Klein, E.Y
name: Lin, G
name: Lessler, J
Publisher: name: W.B. Saunders Ltd
Year: 2023

description: Background: Contact precautions are widely used to prevent the transmission of carbapenem-resistant organisms (CROs) in hospital wards. However, evidence for their effectiveness in natural hospital environments is limited. Objective: To determine which contact precautions, healthcare worker (HCW)–patient interactions, and patient and ward characteristics are associated with greater risk of CRO infection or colonization. Design, setting and participants: CRO clinical and surveillance cultures from two high-acuity wards were assessed through probabilistic modelling to characterize a susceptible patient's risk of CRO infection or colonization during a ward stay. User- and time-stamped electronic health records were used to build HCW-mediated contact networks between patients. Probabilistic models were adjusted for patient (e.g. antibiotic administration) and ward (e.g. hand hygiene compliance, environmental cleaning) characteristics. The effects of risk factors were assessed by adjusted odds ratio (aOR) and 95% Bayesian credible intervals (CrI). Exposures: The degree of interaction with CRO-positive patients, stratified by whether CRO-positive patients were on contact precautions. Main outcomes and measures: The prevalence of CROs and number of new carriers (i.e. incident CRO aquisition). Results: Among 2193 ward visits, 126 (5.8%) patients became colonized or infected with CROs. Susceptible patients had 4.8 daily interactions with CRO-positive individuals on contact precautions (vs 1.9 interactions with those not on contact precautions). The use of contact precautions for CRO-positive patients was associated with a reduced rate (7.4 vs 93.5 per 1000 patient-days at risk) and odds (aOR 0.03, 95% CrI 0.01–0.17) of CRO acquisition among susceptible patients, resulting in an estimated absolute risk reduction of 9.0% (95% CrI 7.6–9.2%). Also, carbapenem administration to susceptible patients was associated with increased odds of CRO acquisition (aOR 2.38, 95% CrI 1.70–3.29). Conclusions and relevance: In this population-based cohort study, the use of contact precautions for patients colonized or infected with CROs was associated with lower risk of CRO acquisition among susceptible patients, even after adjusting for antibiotic exposure. Further studies that include organism genotyping are needed to confirm these findings.
GIS Research UK (GISRUK) 2015 Proceedings
Creators: name: Malleson, Nick
name: Addis, Nicholas
name: Durham, Helen
name: Heppenstall, Alison
name: Lovelace, Robin
name: Norman, Paul
name: Oldroyd, Rachel
Publisher: name: figshare
Year: 2015
Subjects: subject: Geography
subject: Physical Geography
subject: Computer Software
subject: FOS: Computer and information sciences
subject: Applied Computer Science

description: This volume contains the papers presented at GIS Research UK 2015 (GISRUK2015) held at the School of Geography, University of Leeds, on 15-17 April 2015.