cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Political Violence and Conflict Resolution: The Struggle for Peace in Northern Ireland
Creators: name: Fox, Lisa G.
Publisher: name: Old Dominion University Libraries
Year: 2004

description: Political violence, especially in ethnoreligious conflicts, continues to threaten the stability and security of the international environment. Motivations for using violence are complex and can evolve over time. As long as one or more of the motivations continue to exist, parties to a conflict will feel that violence is a legitimate course of action and, thus, the conflict will persist.

Theories about the causes of conflict and the approaches that should be taken to terminate it mostly propose a single approach. A single approach, however, will address certain issues while leaving others unresolved, allowing some motivations to continue stimulating conflict. To bring violence to an end, it is necessary to utilize multiple conflict resolution approaches, addressing the conflict from different perspectives and leading to the elimination of violence. Systematic combination of four essential elements drawn from several approaches provides a more comprehensive model of conflict resolution that can succeed in overcoming the motivations for violence and allow peace to endure. These four elements are a response to the underlying issues, track-two diplomacy, inclusiveness, and third-party assistance.

The case of Northern Ireland demonstrates the efficacy of this comprehensive model. Until all four elements of the model were used during the peace process, attempts to produce peace in this region repeatedly failed. Failed attempts, such as the Sunningdale negotiations, demonstrate the deficiencies of an incomplete peace process. The successful Good Friday negotiations, on the other hand, highlight the benefits of incorporating the four necessary elements into the conflict resolution process.
(100609) Frederick Dods Ashmead
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
TRF1 and TRF2 Differentially Modulate Rad51-Mediated Telomeric and Nontelomeric Displacement Loop Formation in Vitro
Creators: name: Griffith, Jack D.
name: Bower, Brian D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: A growing body of literature suggests that the homologous recombination/repair (HR) pathway cooperates with components of the shelterin complex to promote both telomere maintenance and nontelomeric HR. This may be due to the ability of both HR and shelterin proteins to promote strand invasion, wherein a single-stranded DNA (ssDNA) substrate base pairs with a homologous double-stranded DNA (dsDNA) template displacing a loop of ssDNA (D-loop). Rad51 recombinase catalyzes D-loop formation during HR, and telomere repeat binding factor 2 (TRF2) catalyzes the formation of a telomeric D-loop that stabilizes a looped structure in telomeric DNA (t-loop) that may facilitate telomere protection. We have characterized this functional interaction in vitro using a fluorescent D-loop assay measuring the incorporation of Cy3-labeled 90-nucleotide telomeric and nontelomeric substrates into telomeric and nontelomeric plasmid templates. We report that preincubation of a telomeric template with TRF2 inhibits the ability of Rad51 to promote telomeric D-loop formation upon preincubation with a telomeric substrate. This suggests Rad51 does not facilitate t-loop formation and suggests a mechanism whereby TRF2 can inhibit HR at telomeres. We also report a TRF2 mutant lacking the dsDNA binding domain promotes Rad51-mediated nontelomeric D-loop formation, possibly explaining how TRF2 promotes nontelomeric HR. Finally, we report telomere repeat binding factor 1 (TRF1) promotes Rad51-mediated telomeric D-loop formation, which may facilitate HR-mediated replication fork restart and explain why TRF1 is required for efficient telomere replication.
Zwischen „allumfassender Sorge für unsere Kinder“ und der Erziehung zur „Liebe zur Arbeit“
Between "all-embracing care for our children" and education in the "love of work"
Creators: name: Koebe, Kristina
name: Lanz, Juliane
name: Decker, Clemens
name: Henneberger, Anita
Publisher: name: Universität Rostock, Arbeitsstelle Pädagogische Lesungen
Year: 2022
Subjects: subject: 370 Education
subject: 943 General history of Europe Central Europe Germany

description: Dieser Beitrag betrachtet die Pädagogischen Lesungen zum Thema Patenbrigadearbeit im Kontext anderer Diskurse. Er arbeitet heraus, dass die Lesungen mangels anderer Hilfestellungen eine zentrale Rolle bei der Weiterbildung der Fachkräfte mittels Weitergabe gesammelter Erfahrungen spielten – und, dass das Format ein besonderes Innovationspotential entfalten konnte. Gleichzeitig werden bislang wenig beleuchtete Grenzen des Mediums sichtbar: Offenbar hatten die Pädagogischen Lesungen nach ihrer Entstehung nur eine zeitlich stark befristete Weiterbildungswirkung, wurden also nur in der unmittelbaren Folgezeit breit rezipiert. Dies führte dazu, dass über Dekaden hinweg ähnliche Problemstellungen immer aufs Neue behandelt wurden und Problemlösungssuchen in Form von Empfehlungen nicht aufeinander aufbauten. Ergänzend dazu beleuchtet der Beitrag die pädagogischen Zielsetzungen, die die Verfasser*innen der Texte mit ihrer Arbeit verbanden und leistet damit einen Beitrag zur Rekonstruktion des Formats Patenbrigade als ein in der DDR-Gesellschaft fest verankertes Erziehungs- und Bildungsprojekt.
null Erweiterung der DDR-Lehrer*innenweiterbildung um das Fernsehformat „Von Pädagogen für Pädagogen“ von 1970 bis 1982
The expansion of GDR teacher training by television format “From Educators for Educators” from 1970 to 1982
Creators: name: Koch, Katja
name: Koebe, Kristina
Publisher: name: Universität Rostock, Arbeitsstelle Pädagogische Lesungen
Year: 2021
Subjects: subject: 370 Education
subject: 943 General history of Europe Central Europe Germany

description: Die DDR-Pädagog*innen adressierende Sendereihe „Von Pädagogen für Pädagogen“ wurde 1970 etabliert und in dieser Form über dreizehn Jahre hinweg in ungefähr monatlichen Intervallen ausgestrahlt. Der hiermit vorgelegte Beitrag verortet die Sendung innerhalb der Weiterbildungslandschaft der DDR und bemüht sich um die Rekonstruktion von Sendungsentstehung und -weiterentwicklung. Letztere bietet auch deshalb einen wertvollen Einblick in das Aus- und Weiterbildungssystem der DDR, weil sie sich im Kooperations- aber durchaus auch Spannungsfeld zwischen Ministerium für Volksbildung, Akademie der Pädagogischen Wissenschaften (APW), Zentralinstitut für Weiterbildung (ZIW) und den DDR-Schulen (sowohl in der Funktion als Mitproduzenten als auch als Rezipienten) vollzog. Es wird deutlich, dass das Format stark von ministerialen Vorgaben beeinflusst war, sich gleichzeitig aber auch dem Urteil der Lehrer*innen hinsichtlich seiner praktischen Relevanz stellen musste, um die intendierte Funktion – eine Weiterbildung jenseits der organisierten Veranstaltungen – erfüllen zu können. Die Betrachtungen machen außerdem deutlich, dass die beiden mit der Organisation beauftragten Institutionen (zunächst die APW, dann das ZIW) hierbei durchaus eigene Perspektiven beisteuerten und damit nicht auf die Rolle der Ausführenden von Ministeriumswünschen reduziert werden können. Das Ergebnis der Kooperation war eine Sendereihe, die ein – wissenschaftlich fundiertes – Wunschbild von DDR-Unterricht präsentierte. Gleichzeitig nutzte sie aber auch das Feedback von Praktiker*innen zur Optimierung und ist damit als Dokumentation von durch die Praxis akzeptierten (aber nicht notwendig implementierten) Bildungsidealen einzuordnen.
(100605) Frederick Ashmead
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
An extension of a theorem of Wu-Yau
Creators: name: Tosatti, Valentino
name: Yang, Xiaokui
Publisher: name: arXiv
Year: 2015
Subjects: subject: Differential Geometry (math.DG)
subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 32Q20, 32Q05, 32Q15, 32Q45, 32W20

description: We show that a compact Kahler manifold with nonpositive holomorphic sectional curvature has nef canonical bundle. If the holomorphic sectional curvature is negative then it follows that the canonical bundle is ample, confirming a conjecture of Yau. The key ingredient is the recent solution of this conjecture in the projective case by Wu-Yau.
description: 6 pages; final version to appear in J. Differential Geom
Bedeutung von atrialen Niedervoltagearealen für die Ablationsbehandlung von Vorhofflimmern
Creators: name: Landsmann, Anja
Publisher: name: Universität Rostock
Year: 2018
Subjects: subject: 610 Medical sciences Medicine

description: Ein Wiederauftreten von VHF nach einer PVI und auch das Remodelling des linken Vorhofs, wodurch es im Verlauf zu fortschreitenden strukturellen und elektrophysiologischen Veränderungen des atrialen Gewebes kommt, sind zunehmend Untersuchungsgegenstand in vielen Studien. Der Fokus der vorliegenden Arbeit lag auf der Untersuchung von Patienten hinsichtlich low voltage arealen (LVA) im Vorhof an verschiedenen Eckpunkten. Die Bestimmung von Niedervoltagearealen erwies sich als entscheidendes Kriterium zur Bewertung von LVA. Niederspannungsbereiche scheinen ein eigenständiger Prozess zu sein.
Challenge of Mimicking the Influences of the Cellular Environment on RNA Structure by PEG-Induced Macromolecular Crowding
Creators: name: Pielak, Gary J.
name: Tyrrell, Jillian
name: Weeks, Kevin M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: There are large differences between the cellular environment and the conditions widely used to study RNA in vitro. SHAPE RNA structure probing in Escherichia coli cells has shown that the cellular environment stabilizes both long-range and local tertiary interactions in the adenine riboswitch aptamer domain. Synthetic crowding agents are widely used to understand the forces that stabilize RNA structure and in efforts to recapitulate the cellular environment under simplified experimental conditions. Here, we studied the structure and ligand binding ability of the adenine riboswitch in the presence of the macromolecular crowding agent, polyethylene glycol (PEG). Ethylene glycol and low molecular mass PEGs destabilized RNA structure and caused the riboswitch to sample secondary structures different from those observed in simple buffered solutions or in cells. In the presence of larger PEGs, longer range loop-loop interactions were more similar to those in cells than in buffer alone, consistent with prior work showing that larger PEGs stabilize compact RNA states. Ligand affinity was weakened by low mass PEGs, but increased with high mass PEGs, indicating that PEG cosolvents exert complex chemical and steric effects on RNA structure. Regardless of polymer size, however, nucleotide-resolution structural characteristics observed in cells were not recapitulated in PEG solutions. Our results reveal that the cellular environment is difficult to recapitulate in vitro; mimicking the cellular state will likely require a combination of crowding agents and other chemical species.
The Chemodynamics of the Stellar Populations in M31 from APOGEE Integrated Light Spectroscopy
Creators: name: Gibson, Benjamin J.
name: Zasowski, Gail
name: Seth, Anil
name: Ashok, Aishwarya
name: Goold, Kameron
name: Wainer, Tobin
name: Hasselquist, Sten
name: Holtzman, Jon
name: Imig, Julie
name: Bizyaev, Dmitry
name: Majewski, Steven R.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We present analysis of nearly 1,000 near-infrared, integrated light spectra from APOGEE in the inner $\sim$7 kpc of M31. We utilize full spectrum fitting with A-LIST simple stellar population spectral templates that represent a population of stars with the same age, [M/H], and [$α$/M]. With this, we determine the mean kinematics, metallicities, $α$ abundances, and ages of the stellar populations of M31's bar, bulge, and inner disk ($\sim$4-7 kpc). We find a non-axisymmetric velocity field in M31 resulting from the presence of a bar. The bulge of M31 is metal-poor relative to the disk ([M/H] = $-0.149^{+0.067}_{-0.081}$ dex), features minima in metallicity on either side of the bar ([M/H] $\sim$ -0.2), and is enhanced in $α$ abundance ([$α$/M] = $0.281^{+0.035}_{-0.038}$). The disk of M31 within $\sim$7 kpc is enhanced in both metallicity ([M/H] = $-0.023^{+0.050}_{-0.052}$) and $α$ abundance ([$α$/M] = $0.274^{+0.020}_{-0.025}$). Both of these structural components are uniformly old at $\simeq$ 12 Gyr. We find the metallicity increases with distance from the center of M31, with the steepest gradient along the disk major axis ($0.043\pm0.021$ dex/kpc). This gradient is the result of changing light contributions from the metal-poor bulge and metal-rich disk. The chemodynamics of stellar populations encodes information about a galaxy's chemical enrichment, star formation history, and merger history, allowing us to discuss new constraints on M31's formation. Our results provide a stepping stone between our understanding of the Milky Way and other external galaxies.
title:  U.S. - ASEAN Organized Crime Cooperation as Part of Washington's Rebalancing Policy Toward the Asia-Pacific
Creators: name: Luc, Tuan Anh
Publisher: name: Old Dominion University Libraries
Year: 2014

description: This research addresses the reasons why the United States of America (U.S.) has been involving in the effort of the Association of Southeast Asian Nations (ASEAN) to combat transnational organized crime. The author argues that Washington has been doing so because: first, it wants to prevent and suppress negative influences of Southeast Asian organized crime and protect national interests; second, it wants to increase regional capabilities, sometimes at the Association's request, and narrow differences so as to effectively deal with transnational organized crime; and third, it wants to justify its presence in the region and pave the way for the partial concretization of the rebalancing toward the Asia-Pacific.

The research finds that Washington's level of support to ASEAN's effort to combat transnational organized crime has steadily increased despite the ebbs and flows of the U.S.-ASEAN relationship. Given the fact that organized crime in the region gets worse, ASEAN lacks of capabilities to deal with problems incur, and the region is an important part of its rebalancing policy toward the Asia-Pacific, Washington's level of support to the region is expected to be on the rise. In other words, U.S. - ASEAN organized crime cooperation will be more dynamic in the future.
Dirac Triplet Extension of the MSSM
Creators: name: Alvarado, C.
name: Delgado, A.
name: Martin, A.
name: Ostdiek, B.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In this paper we explore extensions of the Minimal Supersymmetric Standard Model involving two $SU(2)_L$ triplet chiral superfields that share a superpotential Dirac mass yet only one of which couples to the Higgs fields. This choice is motivated by recent work using two singlet superfields with the same superpotential requirements. We find that, as in the singlet case, the Higgs mass in the triplet extension can easily be raised to $125\,\text{GeV}$ without introducing large fine-tuning. For triplets that carry hypercharge, the regions of least fine tuning are characterized by small contributions to the $\mathcal T$ parameter, and light stop squarks, $m_{\tilde t_1} \sim 300-450\,\text{GeV}$; the latter is a result of the $\tanβ$ dependence of the triplet contribution to the Higgs mass. Despite such light stop masses, these models are viable provided the stop-electroweakino spectrum is sufficiently compressed.
description: 26 pages, 4 figures
Novel methods for subcellular in vivo imaging of the cornea with the Rostock Cornea Module 2.0
Creators: name: Bohn, Sebastian
Publisher: name: Universität Rostock
Year: 2021
Subjects: subject: 530 Physics

description: The Rostock Cornea Module transforms a confocal laser scanning ophthalmoscope into a corneal confocal laser scanning microscope. In this thesis, an improved version, the Rostock Cornea Module 2.0, and its achieved results were demonstrated. These include a concave contact cap design to attenuate eye movements to improve 3D volume reconstruction, an oscillating focal plane to improve mosaicking of the subbasal nerve plexus, the integration of simultaneous optical coherence tomography, multiwavelength corneal imaging, the clinical usage, and the automated morphological characterization.
(100606) Harriette Martha Dods
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Gluon distributions in the proton in a light-front spectator model
Creators: name: Chakrabarti, Dipankar
name: Choudhary, Poonam
name: Gurjar, Bheemsehan
name: Kishore, Raj
name: Maji, Tanmay
name: Mondal, Chandan
name: Mukherjee, Asmita
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We formulate a light-front spectator model for the proton incorporating the gluonic degree of freedom. In this model, at high energy scattering of the proton, the active parton is a gluon and the rest is viewed as a spin-$\frac{1}{2}$ spectator with an effective mass. The light front wave functions of the proton are constructed using a soft wall AdS/QCD prediction and parameterized by fitting the unpolarized gluon distribution function to the NNPDF3.0nlo data set. We investigate the helicity distribution of gluon in this model. We find that our prediction for the gluon helicity asymmetry agrees well with existing experimental data and satisfies the perturbative QCD constraints at small and large longitudinal momentum regions. We also present the transverse momentum dependent distributions (TMDs) for gluon in this model. We further show that the model-independent Mulders-Rodrigues inequalities are obeyed by the TMDs computed in our model.
description: 14 pages, 7 figures
Analog Simulation of Weyl Particles with Cold Atoms
Creators: name: Suchet, Daniel
name: Rabinovic, Mihail
name: Reimann, Thomas
name: Kretzschmar, Norman
name: Sievers, Franz
name: Salomon, Christophe
name: Lau, Johnathan
name: Goulko, Olga
name: Lobo, Carlos
name: Chevy, Frédéric
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We study theoretically, numerically, and experimentally the relaxation of a collisionless gas in a quadrupole trap after a momentum kick. The non-separability of the potential enables a quasi thermalization of the single particle distribution function even in the absence of interactions. Suprinsingly, the dynamics features an effective decoupling between the strong trapping axis and the weak trapping plane. The energy delivered during the kick is redistributed according to the symmetries of the system and satisfies the Virial theorem, allowing for the prediction of the final temperatures. We show that this behaviour is formally equivalent to the relaxation of massless relativistic Weyl fermions after a sudden displacement from the center of a harmonic trap.
Reinhard Schindler, Studien zum vorgeschichtlichen Siedlungs- und Befestigungswesen des Saarlandes
Creators: name: Jacobi, Gerhard
Publisher: name: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts
Year: 2023

description: Rezension zu: Reinhard Schindler, Studien zum vorgeschichtlichen Siedlungs- und Befestigungswesen des Saarlandes. Paulinus-Verlag Trier 1968. 204 S., 148 Abbildungen und 15 Beilagen.
description: Germania : Anzeiger der Römisch-Germanischen Kommission des Deutschen Archäologischen Instituts, Bd. 50 (1972)
Circadian Clock, Cancer, and Chemotherapy
Creators: name: Kemp, Michael G.
name: Sancar, Aziz
name: Hu, Jinchuan
name: Ye, Rui
name: Gaddameedhi, Shobhan
name: Lee, Jin Hyup
name: Ozturk, Nuri
name: Chiou, Yi Ying
name: Lindsey-Boltz, Laura A.
name: Selby, Christopher P.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The circadian clock is a global regulatory system that interfaces with most other regulatory systems and pathways in mammalian organisms. Investigations of the circadian clock–DNA damage response connections have revealed that nucleotide excision repair, DNA damage checkpoints, and apoptosis are appreciably influenced by the clock. Although several epidemiological studies in humans and a limited number of genetic studies in mouse model systems have indicated that clock disruption may predispose mammals to cancer, well-controlled genetic studies in mice have not supported the commonly held view that circadian clock disruption is a cancer risk factor. In fact, in the appropriate genetic background, clock disruption may instead aid in cancer regression by promoting intrinsic and extrinsic apoptosis. Finally, the clock may affect the efficacy of cancer treatment (chronochemotherapy) by modulating the pharmacokinetics and pharmacodynamics of chemotherapeutic drugs as well as the activity of the DNA repair enzymes that repair the DNA damage caused by anticancer drugs.
Wissenschaft im Spannungsfeld zwischen Elfenbeinturm, politischer Notwendigkeit und gesellschaftlicher Realität
Creators: name: Lambsdorff, Alexandra
name: Homölle, Susanne
Publisher: name: Universität Rostock, Quistorp Stiftung
Year: 2022
Subjects: subject: 000 Generalities, Science

description: Als Orte der Wissenschaft sind Universitäten ein bedeutender Impulsgeber für technologische, wirtschaftliche und gesellschaftliche Veränderungen. Neben Forschung und Lehre wird der aktive Austausch mit Gesellschaft und Wirtschaft seit einiger Zeit als Third Mission der Universitäten diskutiert. Ein fruchtbarer Austausch lebt von Ideen aus der Wissenschaft, aber auch von der Bereitschaft von Politik und Wirtschaft, sich mit neuen und ggf. unbequemen Erkenntnissen auseinanderzusetzen. Der vorliegende Sammelband umfasst 4 Artikel und 3 Interviews, die sich mit diesem Themenkreis beschäftigen.
Detection of RNA–Protein Interactions in Living Cells with SHAPE
Creators: name: Weeks, Kevin M.
name: Smola, Matthew J.
name: Calabrese, J. Mauro
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: SHAPE-MaP is unique among RNA structure probing strategies in that it both measures flexibility at single-nucleotide resolution and quantifies the uncertainties in these measurements. We report a straightforward analytical framework that incorporates these uncertainties to enable detection of RNA structural differences between any two states, and we use it here to detect RNA-protein interactions in healthy mouse trophoblast stem cells. We validate this approach by analysis of three model cytoplasmic and nuclear ribonucleoprotein complexes, in 2-minute in-cell probing experiments. In contrast, data produced by alternative in-cell SHAPE probing methods correlate poorly (r = 0.2) with those generated by SHAPE-MaP and do not yield accurate signals for RNA-protein interactions. We then examine RNA-protein and RNA-substrate interactions in the RNase MRP complex and, by comparing in-cell interaction sites with disease-associated mutations, characterize these non-coding mutations in terms of molecular phenotype. Together, these results reveal that SHAPE-MaP can define true interaction sites and infer RNA functions under native cellular conditions with limited pre-existing knowledge of the proteins or RNAs involved.
(100607) Sarah Anne Ashmead
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Quantified vehicles
Creators: name: Kaiser, Christian
Publisher: name: Universität Rostock
Year: 2021
Subjects: subject: 004 Data processing Computer sciences
subject: 330 Economics

description: Advancing digitalization has shown the potential of so-called Quantified Vehicles for gathering valuable sensor data about the vehicle itself and its environment. Consequently, (vehicle) Data has become an important resource, which can pave the way to (Data-driven) Services. The (Data-driven Service) Ecosystem of actors that collaborate to ultimately generate services, has only shaped up in recent years. This cumulative dissertation summarizes the author's contributions and includes a synopsis as well as 14 peer-reviewed publications, which contribute to answer the three research questions.
The CRISP colorectal cancer risk prediction tool: an exploratory study using simulated consultations in Australian primary care
Creators: name: Walker, JG
name: Bickerstaffe, A
name: Hewabandu, N
name: Maddumarachchi, S
name: Dowty, JG
name: CRECRC,
name: Jenkins, M
name: Pirotta, M
name: Walter, Fiona
name: Emery, JD
Publisher: name: Apollo - University of Cambridge Repository
Year: 2017
Subjects: Bowel cancer screening
Cancer screening
Colorectal cancer
Colorectal cancer risk assessment
Colorectal cancer risk prediction
General practitioners
Primary care

description: BACKGROUND: In Australia, screening for colorectal cancer (CRC) with colonoscopy is meant to be reserved for people at increased risk, however, currently there is a mismatch between individuals' risk of CRC and the type of CRC screening they receive. This paper describes the development and optimisation of a Colorectal cancer RISk Prediction tool ('CRISP') for use in primary care. The aim of the CRISP tool is to increase risk-appropriate CRC screening. METHODS: CRISP development was informed by previous experience with developing risk tools for use in primary care and a systematic review of the evidence. A CRISP prototype was used in simulated consultations by general practitioners (GPs) with actors as patients. GPs were interviewed to explore their experience of using CRISP, and practice nurses (PNs) and practice managers (PMs) were interviewed after a demonstration of CRISP. Transcribed interviews and video footage of the 'consultations' were qualitatively analyzed. Themes arising from the data were mapped onto Normalization Process Theory (NPT). RESULTS: Fourteen GPs, nine PNs and six PMs were recruited from 12 clinics. Results were described using the four constructs of NPT: 1) Coherence: Clinicians understood the rationale behind CRISP, particularly since they were familiar with using risk tools for other conditions; 2) Cognitive participation: GPs welcomed the opportunity CRISP provided to discuss healthy and unhealthy behaviors with their patients, but many GPs challenged the screening recommendation generated by CRISP; 3) Collective Action: CRISP disrupted clinician-patient flow if the GP was less comfortable with computers. GP consultation time was a major implementation barrier and overall consensus was that PNs have more capacity and time to use CRISP effectively; 4) Reflexive monitoring: Limited systematic monitoring of new interventions is a potential barrier to the sustainable embedding of CRISP. CONCLUSIONS: CRISP has the potential to improve risk-appropriate CRC screening in primary care but was considered more likely to be successfully implemented as a nurse-led intervention.
description: This study was funded by a National Health and Medical Research Council (NHMRC) Centre for Research Excellence grant (APP1042021). M Pirotta is supported by an NHMRC Career Development Fellowship. JD Emery is supported by an NHMRC Practitioner Fellowship. FM Walter is supported by a NIHR Clinician Scientist award.
3D spectroscopy with GTC-MEGARA of the triple AGN candidate in SDSS J102700.40+174900.8
Creators: name: Benítez, Erika
name: Ibarra-Medel, Héctor
name: Negrete, Castalia Alenka
name: Cruz-González, Irene
name: Rodríguez-Espinosa, José Miguel
name: Liu, Xin
name: Shen, Yue
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Triple AGN systems are expected to be the result of the hierarchical model of galaxy formation. Since there are very few of them confirmed as such, we present the results of a new study of the triple-AGN candidate SDSS J102700.40+174900.8 (center nucleus) through observations with $\it{GTC}$-$\it{MEGARA}$ Integral Field Unit. 1D and 2D analysis of the line ratios of the three nuclei allow us to locate them in the EW(H$α$) vs. [Nii] /H$α$ diagram. The central nucleus is found to be a retired galaxy (or fake AGN). The neighbors are found to be a strong AGN (southeastern nucleus, J102700.55+174900.2) compatible with a Sy2 galaxy, and a weak AGN (northern nucleus, J102700.38+174902.6) compatible with a LINER2. We find evidence that the neighbors constitute a dual AGN system (Sy2-LINER2) with a projected separation of 3.98 kpc in the optical bands. The H$α$ velocity map shows that the northern nucleus has an H$α$ emission with a velocity offset of $\sim$-500 km s$^{-1}$, whereas the southeastern nucleus has a rotating disk and H$α$ extended emission at kpc scales. Chandra archival data confirm that the neighbors have X-ray (0.5-2) keV and (2-7) keV emission, whereas the center nucleus shows no X-ray emission. A collisional ring with knots is observed in the HST images of the southeastern nucleus. These knots coincide with star formation regions that along with the ring are predicted in a head-on collision. In this case, the morphology changes are probably due to a minor merger that was produced by the passing of the northern through the southeastern nucleus.
description: Accepted for publication in ApJ, 20 pages, 9 figures, 7 tables
Entamoeba histolytica RacC Selectively Engages p21-Activated Kinase Effectors
Creators: name: Siderovski, David P.
name: Bosch, Dustin E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Rho family GTPases modulate actin cytoskeleton dynamics by signaling through multiple effectors, including the p21-activated kinases (PAKs). The intestinal parasite Entamoeba histolytica expresses ∼20 Rho family GTPases and seven isoforms of PAK, two of which have been implicated in pathogenesis-related processes such as amoebic motility and invasion and host cell phagocytosis. Here, we describe two previously unstudied PAK isoforms, EhPAK4 and EhPAK5, as highly specific effectors of EhRacC. A structural model based on 2.35 Å X-ray crystallographic data of a complex between EhRacCQ65L·GTP and the EhPAK4 p21 binding domain (PBD) reveals a fairly well-conserved Rho/effector interface despite deviation of the PBD α-helix. A structural comparison with EhRho1 in complex with EhFormin1 suggests likely determinants of Rho family GTPase signaling specificity in E. histolytica. These findings suggest a high degree of Rho family GTPase diversity and specificity in the single-cell parasite E. histolytica. Because PAKs regulate pathogenesis-related processes in E. histolytica, they may be valid pharmacologic targets for anti-amoebiasis drugs.
(100602) William Ashmead
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Model Guided Sampling Optimization for Low-dimensional Problems
Creators: name: Bajer, Lukas
name: Holena, Martin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Neural and Evolutionary Computing (cs.NE)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: Optimization of very expensive black-box functions requires utilization of maximum information gathered by the process of optimization. Model Guided Sampling Optimization (MGSO) forms a more robust alternative to Jones' Gaussian-process-based EGO algorithm. Instead of EGO's maximizing expected improvement, the MGSO uses sampling the probability of improvement which is shown to be helpful against trapping in local minima. Further, the MGSO can reach close-to-optimum solutions faster than standard optimization algorithms on low dimensional or smooth problems.
Nuclear T-violation search using octupole-deformed nuclei in a crystal
Creators: name: Ramachandran, Harish D.
name: Vutha, Amar C.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Precision measurements with atoms and molecules can search for subtle violations of time-reversal symmetry (T) in nuclei, and thereby probe a variety of new physics models. We present a detailed scheme for a nuclear T-violation search experiment using $^{153}$Eu$^{3+}$ ions doped in non-centrosymmetric sites within a Y$_2$SiO$_5$ crystal. The ions in this solid contain nuclei that are highly sensitive to T-violation, and avail of large atomic enhancements by being polarized within the solid. But in particular, the system and methods that we discuss here enable the use of vast numbers of nuclei trapped in crystals, while also offering a number of stringent tests to ward off systematic errors. Our approach maps out a path to probe new physics at the PeV energy scale.
description: 10 pages, 3 figures, 5 tables
Imidazole as a Small Molecule Analogue in Two-Component Signal Transduction
Creators: name: Page, Stephani C.
name: Silversmith, Ruth E.
name: Bourret, Robert B.
name: Collins, Edward J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: In two-component signal transduction systems (TCSs), responses to stimuli are mediated through phosphotransfer between protein components. Canonical TCSs use His → Asp phosphotransfer in which phosphoryl groups are transferred from a conserved His on a sensory histidine kinase (HK) to a conserved Asp on a response regulator (RR). RRs contain the catalytic core of His → Asp phosphotransfer, evidenced by the ability of RRs to autophosphorylate with small molecule analogs of phospho-His proteins. Phosphorelays are a more complex variation of TCSs that additionally utilize Asp → His phosphotransfer through the use of an additional component, the histidine-containing phosphotransfer domain (Hpt), which reacts with RRs both as phosphodonors and phosphoacceptors. Here we show that imidazole has features of a rudimentary Hpt. Imidazole acted as a nucleophile and attacked phosphorylated RRs (RR-P) to produce monophosphoimidazole (MPI) and unphosphorylated RR. Phosphotransfer from RR-P to imidazole required the intact RR active site, indicating that the RR provided the core catalytic machinery for Asp → His phosphotransfer. Imidazole functioned in an artificial phosphorelay to transfer phosphoryl groups between unrelated RRs. The X-ray crystal structure of an activated RR•imidazole complex showed imidazole oriented in the RR active site similarly to the His of an Hpt. Imidazole interacted with RR non-conserved active site residues, which influenced the relative reactivity of RR-P with imidazole versus water. Rate constants for reaction of imidazole or MPI with chimeric RRs suggested that the RR active site contributes to the kinetic preferences exhibited by the YPD1 Hpt.
(100604) Martha Ashmead
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Curtain of Silence Japanese in Soviet Custody, 1945-1956
Creators: name: Nimmo, William F.
Publisher: name: Old Dominion University Libraries
Year: 1985

description: The Soviet Union attacked- and defeated Japanese forces in Northeast Asia in the final days of the Second World War, and 2,100,000 Japanese soldiers and civilians suddenly fell into the hands of the Red Army. This thesis examines the experiences of Japanese in Soviet custody, efforts to obtain their release, and their eventual return to Japan. Repatriation of civilians from Soviet-controlled areas was slow, and military personnel were taken to the USSR for use as forced labor for several years. The Soviets conducted an intensive Marxist-Leninist indoctrination program for prisoners of war, and a professed acceptance of communism was a prerequisite for repatriation. Extensive efforts to obtain information about the internees usually ended in frustration, leading one American diplomat to refer to the Soviet position as a ''curtain of silence." Records of the supreme Commander for the Allied Powers (SCAP), maintained at the MacArthur Memorial Archives in Norfolk, Virginia, provided the primary source of information for this research.
Kurzstudie über die Bibliotheksausstattung der Profillinie Maritime Systems an der Universität Rostock im Bereich der Geistes- und Sozialwissenschaften (unter Berücksichtigung der Museumslandschaft)
Creators: name: Koschkar, Martin
name: Saalfeld, Johannes
name: Werz, Nikolaus
name: Wirtschafts- Und Sozialwissenschaftliche Fakultät
Publisher: name: Universität Rostock, Wirtschafts- und Sozialwissenschaftliche Fakultät
Year: 2009
Subjects: subject: 020 Library & information sciences

description: Im Juli 2009 wurde den Verfassern der Auftrag zu einer Kurzstudie über die Bibliotheksausstattung der Profillinie Maritime Systems an der Universität Rostock im Bereich der Geistes- und Sozialwissenschaften unter Berücksichtigung der Museumslandschaft erteilt. Sie wurde in den Monaten September und Oktober 2009 angefertigt und besteht aus vier Teilen: den beiden Schwerpunkten Bibliotheksausstattung und Museumslandschaft, Empfehlungen und einem Anhang.
A Unified Successive Pseudo-Convex Approximation Framework
Creators: name: Yang, Yang
name: Pesavento, Marius
Publisher: name: arXiv
Year: 2015
Subjects: subject: Optimization and Control (math.OC)
subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: In this paper, we propose a successive pseudo-convex approximation algorithm to efficiently compute stationary points for a large class of possibly nonconvex optimization problems. The stationary points are obtained by solving a sequence of successively refined approximate problems, each of which is much easier to solve than the original problem. To achieve convergence, the approximate problem only needs to exhibit a weak form of convexity, namely, pseudo-convexity. We show that the proposed framework not only includes as special cases a number of existing methods, for example, the gradient method and the Jacobi algorithm, but also leads to new algorithms which enjoy easier implementation and faster convergence speed. We also propose a novel line search method for nondifferentiable optimization problems, which is carried out over a properly constructed differentiable function with the benefit of a simplified implementation as compared to state-of-the-art line search techniques that directly operate on the original nondifferentiable objective function. The advantages of the proposed algorithm are shown, both theoretically and numerically, by several example applications, namely, MIMO broadcast channel capacity computation, energy efficiency maximization in massive MIMO systems and LASSO in sparse signal recovery.
description: submitted to IEEE Transactions on Signal Processing; original title: A Novel Iterative Convex Approximation Method
Expression von microRNA durch Einfluss ionisierender Bestrahlung unter Berücksichtigung der Faktoren Dosis und Zeit in Zellen unterschiedlicher Strahlensensibilität
Creators: name: Wohlfahrt, René
Publisher: name: Universität Rostock
Year: 2021
Subjects: subject: 610 Medical sciences Medicine

description: In dieser Arbeit wurde die Wirkung ionisierender Strahlung auf die miRNA-Expression in Zellen unterschiedlicher Strahlensensibilität untersucht. Ein genomweites Screening, von mit 8 Gray bestrahlten Tumorzellen, der Zelllinien HT29 und HCT-116, mittels DNA-hybridisierungsbasierten Microarrays wurde anschließend auf validierte und prognostizierte miRNA-Zielgeninteraktionen, in DNA-Reparaturwegen, analysiert und auf 14 miRNA-Kandidaten reduziert. Die Validierung erfolgte mittels RT-qPCR. Es wurde keine differentielle, bestrahlungsabhängige, Expression der miRNA-Kandidaten nachgewiesen.
High degrees of random recursive trees
Creators: name: Addario-Berry, Louigi
name: Eslava, Laura
Publisher: name: arXiv
Year: 2015
Subjects: subject: Combinatorics (math.CO)
subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 60C05, 05C80

description: For $n\ge 1$, let $T_n$ be a random recursive tree on the vertex set $[n]=\{1,\ldots,n\}$. Let $\mathrm{deg}_{T_n}(v)$ be the degree of vertex $v$ in $T_n$, that is, the number of children of $v$ in $T_n$. Devroye and Lu showed that the maximum degree $Δ_n$ of $T_n$ satisfies $Δ_n/\lfloor \log_2 n\rfloor \to 1$ almost surely; Goh and Schmutz showed distributional convergence of $Δ_n - \lfloor \log_2 n \rfloor$ along suitable subsequences. In this work we show how a version of Kingman's coalescent can be used to access much finer properties of the degree distribution in $T_n$. For any $i\in \mathbb{Z}$, let $X_i^{(n)}=|\{v\in [n]: \mathrm{deg}_{T_n}(v)= \lfloor \log n\rfloor +i\}|$. Also, let $\mathcal{P}$ be a Poisson point process on $\mathbb{R}$ with rate function $λ(x)=2^{-x}\cdot \ln 2$. We show that, up to lattice effects, the vectors $(X_i^{(n)},\, i\in \mathbb{Z})$ converge weakly in distribution to $(\mathcal{P}[i,i+1),\, i\in \mathbb{Z})$. We also prove asymptotic normality of $X_i^{(n)}$ when $i=i(n) \to -\infty$ slowly, and obtain precise asymptotics for $\mathbb{P}(Δ_n - \log_2 n > i)$ when $ i(n) \to \infty$ and $i(n)/\log n$ is not too large. Our results recover and extends the previous results on maximal and near-maximal degrees in random recursive trees.
description: 15 pages, 3 figures. Revised proof of Proposition 4.5, results unchanged
Retrospektive Analyse des Einflusses von symptomatischen epileptischen Anfällen auf die Prognose von Patienten mit Subarachnoidalblutungen
Creators: name: Kurtieiev, Kyrylo
Publisher: name: Universität Rostock
Year: 2020
Subjects: subject: 610 Medical sciences Medicine

description: Symptomatische epileptische Anfälle sind eine wichtige Komplikation bei der Subarachnoidalblutung (SAB). Es existieren Daten, die einen Einfluss auf das funktionelle und kognitive Outcome gezeigt haben. Allerdings wurden in den früheren Studien fast nur die Patienten mit aneurysmatischen SAB untersucht. Das Ziel der vorliegenden Arbeit besteht in der Beschreibung der Inzidenz und Identifizierung der Risikofaktoren für das Auftreten der akuten symptomatischen und unprovozierten epileptischen Anfällen bei den Patienten mit verschiedenen Typen einer SAB und ihr Einfluss auf die Prognose.
Leberspezifisches Silencing von Repin1 in der steatotischen Leber
Creators: name: Fischer, Felix
Publisher: name: Universität Rostock
Year: 2021
Subjects: subject: 610 Medical sciences Medicine

description: Die hier präsentierte Studie zeigt, dass ein Gen-Silencing über eine Liposomen-vermittelte RNA-Interferenz einen effektiven Weg zur gezielten Modulation der Proteinbiosynthese von potentiellen Therapiegenen in der Leber darstellt. Die wiederholte Applikation von siRepin1-Lipoplexen führte zu einer signifikant reduzierten Repin1 mRNA Expression in der steatotischen Leber von STZ/HFD-Mäusen. Über einen 14-tägigen Therapiezeitraum können inhibitorische Effekte auf Inflammation sowie Fibrogenese erzielt werden.