Additional file 1 of Circulating bilirubin levels and risk of colorectal cancer: serological and Mendelian randomization analyses
Creators: name: Seyed Khoei, Nazlisadat
name: Jenab, Mazda
name: Murphy, Neil
name: Banbury, Barbara L.
name: Carreras-Torres, Robert
name: Viallon, Vivian
name: Kühn, Tilman
name: Bueno-de-Mesquita, Bas
name: Aleksandrova, Krasimira
name: Cross, Amanda J.
name: Weiderpass, Elisabete
name: Stepien, Magdalena
name: Bulmer, Andrew
name: Tjønneland, Anne
name: Boutron-Ruault, Marie-Christine
name: Severi, Gianluca
name: Carbonnel, Franck
name: Katzke, Verena
name: Boeing, Heiner
name: Bergmann, Manuela M.
name: Trichopoulou, Antonia
name: Karakatsani, Anna
name: Martimianaki, Georgia
name: Palli, Domenico
name: Tagliabue, Giovanna
name: Panico, Salvatore
name: Tumino, Rosario
name: Sacerdote, Carlotta
name: Skeie, Guri
name: Merino, Susana
name: Bonet, Catalina
name: Rodríguez-Barranco, Miguel
name: Gil, Leire
name: Chirlaque, Maria-Dolores
name: Ardanaz, Eva
name: Myte, Robin
name: Hultdin, Johan
name: Perez-Cornago, Aurora
name: Aune, Dagfinn
name: Tsilidis, Konstantinos K.
name: Albanes, Demetrius
name: Baron, John A.
name: Berndt, Sonja I.
name: Bézieau, Stéphane
name: Brenner, Hermann
name: Campbell, Peter T.
name: Casey, Graham
name: Chan, Andrew T.
name: Chang-Claude, Jenny
name: Chanock, Stephen J.
name: Cotterchio, Michelle
name: Gallinger, Steven
name: Gruber, Stephen B.
name: Haile, Robert W.
name: Hampe, Jochen
name: Hoffmeister, Michael
name: Hopper, John L.
name: Hsu, Li
name: Huyghe, Jeroen R.
name: Jenkins, Mark A.
name: Joshi, Amit D.
name: Kampman, Ellen
name: Larsson, Susanna C.
name: Le Marchand, Loic
name: Li, Christopher I.
name: Li, Li
name: Lindblom, Annika
name: Lindor, Noralane M.
name: Martín, Vicente
name: Moreno, Victor
name: Newcomb, Polly A.
name: Offit, Kenneth
name: Ogino, Shuji
name: Parfrey, Patrick S.
name: Pharoah, Paul D. P.
name: Rennert, Gad
name: Sakoda, Lori C.
name: Schafmayer, Clemens
name: Schmit, Stephanie L.
name: Schoen, Robert E.
name: Slattery, Martha L.
name: Thibodeau, Stephen N.
name: Ulrich, Cornelia M.
name: van Duijnhoven, Franzel J. B.
name: Weigl, Korbinian
name: Weinstein, Stephanie J.
name: White, Emily
name: Wolk, Alicja
name: Woods, Michael O.
name: Wu, Anna H.
name: Zhang, Xuehong
name: Ferrari, Pietro
name: Anton, Gabriele
name: Peters, Annette
name: Peters, Ulrike
name: Gunter, Marc J.
name: Wagner, Karl-Heinz
name: Freisling, Heinz
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 1 Supplementary tables 1–6, supplementary figures 1–3, supplementary text 1. Suppl. table 1 - Summary statistics for the genetic association with bilirubin levels, and sex-stratified colorectal cancer risk. Suppl. table 2 - Participating studies in the genetic consortia (GECCO/ CCFR/ and CORECT). Suppl. table 3 - Associations between unconjugated bilirubin (UCB) levels and colorectal cancer risk after different sensitivity analyses in the EPIC study. Suppl. table 4 - Results for the Mendelian randomization sensitivity analyses. Suppl. table 5 - Results for the Mendelian randomization sensitivity analyses: positive control outcomes for pancreatic cancer. Suppl. table 6 - Results for genome-wide associations of instruments with other phenotypes. Suppl. figure 1 - Cubic spline modeling of unconjugated bilirubin (UCB) levels in relation to colorectal cancer risk in the EPIC study. Suppl. figure 2 - Association between UGT1A1 polymorphism (rs6431625) and unconjugated bilirubin (UCB) levels in the EPIC study (with available GWAS data). Suppl. figure 3 - Directed acyclic graph (DAG) of the causal structure of associations between unconjugated bilirubin (UCB) levels in relation to colorectal cancer risk in the EPIC study. Suppl. text 1 - Specific funding sources and acknowledgements of participating studies.