title: ÐÐµÑÐ°Ð±Ð¾Ð»Ð¸Ð·Ð¼ ÑÐµÑÐ¾ÑÐ¾Ð½Ð¸Ð½Ð° Ð¿ÑÐ¸ Ð³ÐµÐ½ÐµÑÐ¸ÑÐµÑÐºÐ¸ Ð´ÐµÑÐµÑÐ¼Ð¸Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð¼ Ð½Ð°ÑÑÑÐµÐ½Ð¸Ð¸ Ð¾Ð±Ð¼ÐµÐ½Ð° Ð´Ð¾ÑÐ°Ð¼Ð¸Ð½Ð°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Serotonin metabolism in genetically determined dopamine metabolism disorders
Creators: name: Ð¢ÑÐ°ÐºÑÐ¸ÑÐ¾Ð², ÐÐ¼Ð¸ÑÑÐ¸Ð¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2021
Subjects: ÐÐ¸Ð¾ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸Ñ
ÐÐ»ÐµÑÐºÐ° (Ð±Ð¸Ð¾Ð».)
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ÑÐµÑÐ¾ÑÐ¾Ð½Ð¸Ð½
Ð¼Ð¾Ð½Ð¾Ð°Ð¼Ð¸Ð½Ñ
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Ð½Ð¾ÐºÐ°ÑÑ Ð³ÐµÐ½Ð°
DAT-KO

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ Ð¼ÐµÑÐ°Ð±Ð¾Ð»Ð¸Ð·Ð¼Ð° ÑÐµÑÐ¾ÑÐ¾Ð½Ð¸Ð½Ð° Ð¿ÑÐ¸ Ð³ÐµÐ½ÐµÑÐ¸ÑÐµÑÐºÐ¸ Ð´ÐµÑÐµÑÐ¼Ð¸Ð½Ð¸ÑÐ¾Ð²Ð°Ð½Ð½Ð¾Ð¼ Ð½Ð°ÑÑÑÐµÐ½Ð¸Ð¸ Ð¾Ð±Ð¼ÐµÐ½Ð° Ð´Ð¾ÑÐ°Ð¼Ð¸Ð½Ð°. ÐÐ¾ÑÐ°Ð¼Ð¸Ð½ÐµÑÐ³Ð¸ÑÐµÑÐºÐ°Ñ Ð¸ ÑÐµÑÐ¾ÑÐ¾Ð½Ð¸Ð½ÐµÑÐ³Ð¸ÑÐµÑÐºÐ°Ñ Ð½ÐµÐ¹ÑÐ¾Ð¼ÐµÐ´Ð¸Ð°ÑÐ¾ÑÐ½ÑÐµ ÑÐ¸ÑÑÐµÐ¼Ñ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÑÑÑ ÑÐµÑÐµÐ½Ð¸Ðµ Ð²ÑÐµÑ ÑÑÐ½Ð´Ð°Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÑ Ð´Ð»Ñ Ð¦ÐÐ¡ Ð¿ÑÐ¾ÑÐµÑÑÐ¾Ð², Ð¾Ð´Ð½Ð°ÐºÐ¾ Ð² Ð»Ð¸ÑÐµÑÐ°ÑÑÑÐµ ÑÐ¾Ð´ÐµÑÐ¶Ð¸ÑÑÑ Ð¼Ð°Ð»Ð¾ Ð´Ð°Ð½Ð½ÑÑ Ð¾Ð± Ð¸Ñ Ð²Ð·Ð°Ð¸Ð¼Ð¾Ð´ÐµÐ¹ÑÑÐ²Ð¸Ð¸. Ð¦ÐµÐ»ÑÑ Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ ÑÐ²Ð»ÑÐ»Ð¾ÑÑ Ð²ÑÑÐ²Ð»ÐµÐ½Ð¸Ðµ ÑÑÑÐµÐºÑÐ¾Ð² Ð½Ð¾ÐºÐ°ÑÑÐ° Ð³ÐµÐ½Ð° Ð¾Ð±ÑÐ°ÑÐ½Ð¾Ð³Ð¾ Ð·Ð°ÑÐ²Ð°ÑÐ° Ð´Ð¾ÑÐ°Ð¼Ð¸Ð½Ð° (DAT) Ð½Ð° Ð¾Ð±Ð¼ÐµÐ½ ÑÐµÑÐ¾ÑÐ¾Ð½Ð¸Ð½Ð° Ð¸ Ð½Ð° Ð¿Ð¾Ð²ÐµÐ´ÐµÐ½Ð¸Ðµ ÐºÑÑÑ Ð»Ð¸Ð½Ð¸Ð¸ DAT-KO (Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÐµ, Ð½Ð¾ÐºÐ°ÑÑÐ½ÑÐµ Ð¿Ð¾ Ð³ÐµÐ½Ñ ÑÑÐ°Ð½ÑÐ¿Ð¾ÑÑÐµÑÐ° Ð´Ð¾ÑÐ°Ð¼Ð¸Ð½Ð° â DAT). Ð ÑÐ¾Ð´Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð±ÑÐ»Ð¾ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð½Ð¾, ÑÑÐ¾ DAT-KO ÐºÑÑÑÑ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸Ð·ÑÑÑÑÑ Ð¿Ð¾Ð²ÑÑÐµÐ½Ð½Ð¾Ð¹ Ð»Ð¾ÐºÐ¾Ð¼Ð¾ÑÐ¾ÑÐ½Ð¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑÑ Ð¸ Ð½Ð°ÑÑÑÐµÐ½Ð¸ÐµÐ¼ ÐºÐ¾Ð³Ð½Ð¸ÑÐ¸Ð²Ð½ÑÑ ÑÑÐ½ÐºÑÐ¸Ð¹. ÐÐ¾ÐºÐ°ÑÑ Ð³ÐµÐ½Ð° DAT Ð¿ÑÐ¸Ð²Ð¾Ð´Ð¸Ñ Ðº ÑÐµÐ³Ð¸Ð¾Ð½-ÑÐ¿ÐµÑÐ¸ÑÐ¸ÑÐµÑÐºÐ¸Ð¼ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸ÑÐ¼ ÑÐºÐ¾ÑÐ¾ÑÑÐ¸ Ð¼ÐµÑÐ°Ð±Ð¾Ð»Ð¸Ð·Ð¼Ð° Ð´Ð¾ÑÐ°Ð¼Ð¸Ð½Ð° Ð¸ ÑÐµÑÐ¾ÑÐ¾Ð½Ð¸Ð½Ð°, Ð° ÑÐ°ÐºÐ¶Ðµ Ðº Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ Ð¿ÑÐ¾Ð´ÑÐºÑÐ¸Ð¸ Ð¼Ð ÐÐ ÑÐµÑÐ¼ÐµÐ½ÑÐ¾Ð² Ð¼ÐµÑÐ°Ð±Ð¾Ð»Ð¸Ð·Ð¼Ð° Ð¼Ð¾Ð½Ð¾Ð°Ð¼Ð¸Ð½Ð¾Ð² (Ð¼Ð¾Ð½Ð¾Ð°Ð¼Ð¸Ð½Ð¾ÐºÑÐ¸Ð´Ð°Ð·Ñ Ð, Ð¼Ð¾Ð½Ð¾Ð°Ð¼Ð¸Ð½Ð¾ÐºÑÐ¸Ð´Ð°Ð·Ñ Ð, ÐºÐ°ÑÐµÑÐ¾Ð»Ð-Ð¼ÐµÑÐ¸Ð»ÑÑÐ°Ð½ÑÑÐµÑÐ°Ð·Ñ).
description: This work is devoted to the study of serotonin metabolism in genetically determined disorders of dopamine metabolism. Dopaminergic and serotonergic neurotransmitter systems determine all processes fundamental for the central nervous system, but, however, the literature contains little data on their interaction. The aim of this work was to identify the effects of dopamine transporter gene knockout (DAT) on serotonin metabolism and behavior of DAT-KO rats. During the study, it was shown that DAT-KO rats are characterized by increased locomotor activity and impaired cognitive functions. Knockout of the DAT gene leads to regional changes in the metabolic rate of dopamine and serotonin, as well as to changes in the metabolism of mRNA of enzymes of monoamine metabolism (monoaminoxidase A, monoamineoxidase B, catechol-O-methyltransferase).