cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Discovery of an Exceptionally Strong $β$-Decay Transition of $^{20}$F and Implications for the Fate of Intermediate-Mass Stars
Creators: name: Kirsebom, O. S.
name: Jones, S.
name: Strömberg, D. F.
name: Martínez-Pinedo, G.
name: Langanke, K.
name: Roepke, F. K.
name: Brown, B. A.
name: Eronen, T.
name: Fynbo, H. O. U.
name: Hukkanen, M.
name: Idini, A.
name: Jokinen, A.
name: Kankainen, A.
name: Kostensalo, J.
name: Moore, I.
name: Möller, H.
name: Ohlmann, S. T.
name: Penttilä, H.
name: Riisager, K.
name: Rinta-Antila, S.
name: Srivastava, P. C.
name: Suhonen, J.
name: Trzaska, W. H.
name: Äystö, J.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Nuclear Experiment (nucl-ex)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: A significant fraction of stars between 7-11 solar masses are thought to become supernovae, but the explosion mechanism is unclear. The answer depends critically on the rate of electron capture on $^{20}$Ne in the degenerate oxygen-neon stellar core. However, due to the unknown strength of the transition between the ground states of $^{20}$Ne and $^{20}$F, it has not previously been possible to fully constrain the rate. By measuring the transition, we have established that its strength is exceptionally large and enhances the capture rate by several orders of magnitude. This has a decisive impact on the evolution of the core, increasing the likelihood that the star is (partially) disrupted by a thermonuclear explosion rather than collapsing to form a neutron star. Importantly, our measurement resolves the last remaining nuclear physics uncertainty in the final evolution of degenerate oxygen-neon stellar cores, allowing future studies to address the critical role of convection, which at present is poorly understood.
description: 6 pages, 5 figures, supplemental material; submitted to Science on January 26, 2019; revised version submitted to Physical Review Letters on May 22, 2019; re-submitted to Physical Review Letters on August 15, 2019, after minor revisions; revised title
A Revolution Domesticated: Negotiating Family Life in Urban China, 1959-1984
Creators: Huang, Yanjie
Publisher: name: Columbia University
Year: 2021
Subjects: History
Chinese
Communism
Capitalism
Youth movements
Twentieth century
Great Leap Forward (China : 1958-1960)
Households--Economic aspects

description: Based on newfound family letters, factory archives, oral history, and offiicial publications in Shanghai and other Chinese cities, this dissertation examines how urban Chinese families weathered the economic aftermath of the Great Leap Forward and the Cultural Revolution by negotiating with the austerity measures, official ideology, and street-level bureaucracy. Such multivalent negotiations gave rise to "xiaokang", a “Confucianized” doctrine of depoliticized economic development, providing a durable basis for socialist China’s integration with the capitalist world order. A Shanghai-focused history of urban household economy and grassroots ideology in socialist China, this dissertation explains how urban families shaped modern China’s state-society dynamics and charted China’s unique transition away from Communism. Urban families’ experiences in late Maoist China were profoundly shaped by “revolutionary austerity”, characterized by ideological mobilization of urban families to bear the costs of Mao’s continuous revolution. By separating millions of teenagers from their families, the send-down youths movement (1968-1980) marked the austerity's apex. Instead of continuing the revolution, the send-down youths movement and other revolutionary austerity measures transformed urban families into smaller, more efficient, and depoliticized economic units. Once the ideologically disillusioned and economically strained sent-down youths negotiated the difficult bureaucratic terrain to achieve family reunion, they reinvested the virtue of sacrifice to the “possessive vision” of family life and the cultivation of their single child. By examining eight collections of Mao-era family letters in the context of larger historical processes, this dissertation demonstrates a significant shift in the late Maoist household economy and grassroots sentiments undergirding China’s "xiaokang" ideology.
Ichneumon languidus WESMAEL 1845
Creators: name: Kolarov, J.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Ichneumonidae
Ichneumon
Ichneumon languidus

description: Ichneumon languidus WESMAEL 1845
 Ichneumon languidus WESMAEL 1845. Nouv. Mem. Acad. Sc. Brux. 18: 52.
 Ichneumon languidus: MOCSARY 1897: 35, Croatia; HEINRICH 1930: 120; HILPERT 1992: 216.
D i s t r i b u t i o n:Europe.
description: Published as part of Kolarov, J., 2008, A Catalogue of the [former] Yugoslavian Ichneumonidae (Hymenoptera, Insecta), pp. 1585-1739 in Linzer biologische Beiträge 40 (2) on page 1662, DOI: 10.5281/zenodo.5431642
The Space of Triangles, Vanishing Theorems, and Combinatorics
Creators: name: van der Kallen, Wilberd
name: Magyar, Peter
Publisher: name: arXiv
Year: 1996
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 05E10 05E15 14M15 (Primary) 14F17 (Secondary)

description: We consider compactifications of the space of triples of distinct points in projective $n$-space. One such space is a singular variety of configurations of points and lines; another is the smooth compactification of Fulton and MacPherson; and a third is the triangle space of Schubert and Semple. We compute the sections of line bundles on these spaces, and show that they are equal as GL(n) representations to the generalized Schur modules associated to ``bad'' generalized Young diagrams with three rows (Borel-Weil theorem). On the one hand, this yields Weyl-type character and dimension formulas for the Schur modules; on the other, a combinatorial picture of the space of sections. Cohomology vanishing theorems play a key role in our analysis.
description: LaTeX Version 2.09 <7 Dec 1989>, 38 pages, author-supplied PostScript file available at http://www.math.ruu.nl/people/vdkallen/triang.ps.gz
Effects of the equation of state on the bulk properties of maximally-rotating neutron stars
Creators: name: Koliogiannis, P. S.
name: Moustakidis, Ch. C.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Neutron stars are among the densest known objects in the universe and an ideal laboratory for the strange physics of super-condensed matter. While the simultaneously measurements of mass and radius of non-rotating neutron stars may impose constraints on the properties of the dense nuclear matter, the observation and study of maximally-rotating ones, close to the mass-shedding limit, may lead to significantly further constraints. Theoretical predictions allow neutron stars to rotate extremely fast (even more than $2000 \ {\rm Hz}$). However, until this moment, the fastest observed rotating pulsar has a frequency of $716 \ {\rm Hz}$, much lower compared to the theoretical predictions. There are many suggestions for the mechanism which lead to this situation. In any case, the theoretical study of uniformly rotating neutron stars, along with the accurate measurements, may offer rich information concerning the high density part of the equation of state. In addition, neutron stars through their evolution, may provide us with a criteria to determine the final fate of a rotating compact star. Sensitivity of bulk neutron stars properties on the equation of state at the mass-shedding limit are the main subject of the present study.
description: v1: 16 pages, 24 figures. v2: 18 pages, 14 labeled figures, 5 tables, sections and references had been updated, accepted for publication in Phys. Rev. C
Combinatorics of branchings in higher dimensional automata
Creators: name: Gaucher, Philippe
Publisher: name: arXiv
Year: 1999
Subjects: subject: Category Theory (math.CT)
subject: Other Computer Science (cs.OH)
subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics
subject: FOS: Computer and information sciences
subject: 55U

description: We explore the combinatorial properties of the branching areas of execution paths in higher dimensional automata. Mathematically, this means that we investigate the combinatorics of the negative corner (or branching) homology of a globular $ω$-category and the combinatorics of a new homology theory called the reduced branching homology. The latter is the homology of the quotient of the branching complex by the sub-complex generated by its thin elements. Conjecturally it coincides with the non reduced theory for higher dimensional automata, that is $ω$-categories freely generated by precubical sets. As application, we calculate the branching homology of some $ω$-categories and we give some invariance results for the reduced branching homology. We only treat the branching side. The merging side, that is the case of merging areas of execution paths is similar and can be easily deduced from the branching side.
description: Final version, see http://www.tac.mta.ca/tac/volumes/8/n12/abstract.html
Anacassis rubronotata
Creators: name: Simões, Marianna V. P.
name: Husemann, Martin
name: Sekerka, Lukáš
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Chrysomelidae
Anacassis
Anacassis rubronotata

description: Anacassis rubronotata (Boheman, 1854)
 Additional Specimens Examined. BRAZIL: Paraná: without additional data, Emil Ross Berlin Collection N 113 (1 specimen).
 Distribution. Brazil (S~ ao Paulo) (Borowiec and Świętojańska 2020). New state record for Brazil (Paraná).
description: Published as part of Simões, Marianna V. P., Husemann, Martin & Sekerka, Lukáš, 2021, A Catalog of the Tortoise Beetle (Coleoptera: Chrysomelidae: Cassidinae) Collection Deposited in the Zoological Museum Hamburg (ZMH), pp. 191-210 in The Coleopterists Bulletin 75 (1) on page 205, DOI: 10.1649/0010-065X-75.1.191, http://zenodo.org/record/5454573
Ichneumon phaeostigmus WESMAEL 1857
Creators: name: Kolarov, J.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Ichneumonidae
Ichneumon
Ichneumon phaeostigmus

description: Ichneumon phaeostigmus WESMAEL 1857
 Ichneumon phaeostigmus WESMAEL 1857. Bull. Acad. Sc. Belg. 2: 373.
 Ichneumon phaeostigmus: SCHMIEDEKNECHT 1928: 266, Croatia; MEYER 1933: 142, Croatia; CONSTANTINEANU 1959: 405, Croatia; SELFA 1994: 199: SELFA 1996: 184.
 Ichneumon melanostigma: MOCSARY 1897: 35, Croatia.
D i s t r i b u t i o n: Europe and Israel.
description: Published as part of Kolarov, J., 2008, A Catalogue of the [former] Yugoslavian Ichneumonidae (Hymenoptera, Insecta), pp. 1585-1739 in Linzer biologische Beiträge 40 (2) on page 1663, DOI: 10.5281/zenodo.5431642
Security: An Australian Genealogy
Creators: name: Burke, Anthony
Publisher: name: The Australian National University
Year: 1998

description: This thesis is a study of the deployment and operation of security through Australian political history. In doing so, it takes a distinctive approach to both the concept of security and the historical material which it encounters. Rather than seeing security as an ontologically stable concept or state of affairs, it analyses security as a political technology which has had a profound impact on the political, cultural and economic forms of life which have been held to characterise the Australian nation and the modernisation path of the Asia-Pacific region. In fact, it argues that security needs to be placed alongside a range of other economic, political, technological, philosophic and scientific developments as one of the key events of our modernity. By the beginning of the twentieth century security had been entrenched as a unique and pervasive form which combined 'totalising'and 'individualising' modes of power-here liberal constructions of atomistic, acquisitive subjectivity were integrated with a strong image of the nation-statel which became the principle for a movement of geopolitical power in which colonisation and trade were portrayed as progressive and universalising forces. In its practical operation, security thus combines modes of personal identity and discipline with macroeconomic management and international policy. The remainder of the thesis describes this technology's operation through the history of Australia and its region, from the initial impetus for colonisation in the desire of the British to rid their island of an entire criminal class, to the construction of an allegedly whole 'Australian' subject at Federation in confrontation with racial, industrial and geopolitical images of the Other. It then traces this politics of security and identity through the vast sacrifice of the Great War, the division and trauma of the Depression, the patriotic struggle for survival of the Pacific War, and the militarism and 'development' of the Cold War, concluding with a chapter which examines how dramatic surface changes in the national identity after 1969 were marred by an underlying continuity to which the violence and rigidity of the past remained essential. In this way the tragedies of East Timor, Cambodia or Soeharto's Indonesia were politically (and ontologically) continuous with the Vietnam war and the genocidal assault on Australia's Aboriginal peoples. The thesis concludes by speculating that a path beyond security will simultaneously empower subjects to challenge the forms of power which construct them and, at the level of the state and economy, will replace a coercive and exploitative relation to difference with an 'ethic of engagement' in which the Other might finally begin to speak on its own terms.
PAC-Bayes Un-Expected Bernstein Inequality
Creators: name: Mhammedi, Zakaria
name: Grunwald, Peter D.
name: Guedj, Benjamin
Publisher: name: arXiv
Year: 2019
Subjects: subject: Machine Learning (cs.LG)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: We present a new PAC-Bayesian generalization bound. Standard bounds contain a $\sqrt{L_n \cdot \KL/n}$ complexity term which dominates unless $L_n$, the empirical error of the learning algorithm's randomized predictions, vanishes. We manage to replace $L_n$ by a term which vanishes in many more situations, essentially whenever the employed learning algorithm is sufficiently stable on the dataset at hand. Our new bound consistently beats state-of-the-art bounds both on a toy example and on UCI datasets (with large enough $n$). Theoretically, unlike existing bounds, our new bound can be expected to converge to $0$ faster whenever a Bernstein/Tsybakov condition holds, thus connecting PAC-Bayesian generalization and {\em excess risk\/} bounds---for the latter it has long been known that faster convergence can be obtained under Bernstein conditions. Our main technical tool is a new concentration inequality which is like Bernstein's but with $X^2$ taken outside its expectation.
description: 24 pages, 6 figures. To Appear in NeurIPS2019
Incremental construction of minimal acyclic finite-state automata
Creators: name: Daciuk, Jan
name: Mihov, Stoyan
name: Watson, Bruce
name: Watson, Richard
Publisher: name: arXiv
Year: 2000
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences
subject: I.2.7

description: In this paper, we describe a new method for constructing minimal, deterministic, acyclic finite-state automata from a set of strings. Traditional methods consist of two phases: the first to construct a trie, the second one to minimize it. Our approach is to construct a minimal automaton in a single phase by adding new strings one by one and minimizing the resulting automaton on-the-fly. We present a general algorithm as well as a specialization that relies upon the lexicographical ordering of the input strings.
description: 14 pages, 7 figures
Predstavitev (dobrih) praks pri izvajanju in vodenju mednarodnih raziskovalnih projektov
Creators: name: Kovač, Jernej
Publisher: name: Zenodo
Year: 2024
Subjects: Project management

description: Predstavitev z naslovom Predstavitev (dobrih) praks pri izvajanju in vodenju mednarodnih raziskovalnih projektov, ki je bila predstavljena na dogodku Letno srečanje partnerjev konzorcija KRPAN z izmenjavo dobrih praks, 9. aprila 2024. Dogodek je bil izpeljan v okviru projekta KRPAN v organizaciji Instituta "Jožef Stefan".
Name Strategy: Its Existence and Implications
Creators: name: Roberts, Mark D.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Computation and Language (cs.CL)
subject: Artificial Intelligence (cs.AI)
subject: History and Overview (math.HO)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics
subject: I.2.6;J.4;I.2.7

description: It is argued that colour name strategy, object name strategy, and chunking strategy in memory are all aspects of the same general phenomena, called stereotyping. It is pointed out that the Berlin-Kay universal partial ordering of colours and the frequency of traffic accidents classified by colour are surprisingly similar. Some consequences of the existence of a name strategy for the philosophy of language and mathematics are discussed. It is argued that real valued quantities occur {\it ab initio}. The implication of real valued truth quantities is that the {\bf Continuum Hypothesis} of pure mathematics is side-stepped. The existence of name strategy shows that thought/sememes and talk/phonemes can be separate, and this vindicates the assumption of thought occurring before talk used in psycholinguistic speech production models.
description: 32 pages, 2 ascii diagrams
Additional file 3: of Elevated levels of circulating ITIH4 are associated with hepatocellular carcinoma with nonalcoholic fatty liver disease: from pig model to human study
Creators: name: Nakamura, Naohiko
name: Etsuro Hatano
name: Kohta Iguchi
name: Sato, Motohiko
name: Kawaguchi, Hiroaki
name: Ohtsu, Iwao
name: Takaki Sakurai
name: Aizawa, Nobuhiro
name: Iijima, Hiroko
name: Nishiguchi, Shuhei
name: Tomono, Takuya
name: Okuda, Yukihiro
name: Seidai Wada
name: Seo, Satoru
name: Taura, Kojiro
name: Uemoto, Shinji
name: Ikegawa, Masaya
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Inorganic Chemistry
subject: Science Policy

description: Table S1. Univariate and multivariate analyses for overall survival of HCC with NAFLD patients. Table S2. Serum ITIH4 intensity of patients in subgroup analysis in terms of the fibrosis severity. (DOCX 33 kb)
Additional file 5: of Intertumoral heterogeneity in patient-specific drug sensitivities in treatment-naïve glioblastoma
Creators: name: Skaga, Erlend
name: Kulesskiy, Evgeny
name: Fayzullin, Artem
name: Sandberg, Cecilie
name: Swapnil Potdar
name: Kyttälä, Aija
name: Langmoen, Iver
name: Laakso, Aki
name: Gaál-Paavola, Emília
name: Perola, Markus
name: Wennerberg, Krister
name: Vik-Mo, Einar
Publisher: name: figshare
Year: 2019
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Gene expression analyses of GSC cultures related to selected genes of drug resistance, metabolism, GSC- and GBM genes. Unsupervised hierarchical clustering of expressed genes related to (A) drug resistance, (B) drug metabolism, (C) GSCs, and (D) GBM. In all analyses of selected gene panels, the clusters do not separate the most sensitive tumors from the others. Scale bar in all heat maps: log2-values. The cultures highlighted in red text were the two most sensitive GSC cultures from the drug screening. (PDF 289 kb)
X-ray Plateaus in Gamma Ray Bursts' light-curves from jets viewed slightly off-axis
Creators: name: Beniamini, Paz
name: Duque, Raphael
name: Daigne, Frederic
name: Mochkovitch, Robert
Publisher: name: arXiv
Year: 2019
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Using multiple observational arguments, recent work has shown that cosmological GRBs are typically viewed at angles within, or close to the cores of their relativistic jets. One of those arguments relied on the lack of tens-of-days-long periods of very shallow evolution that would be seen in the afterglow light-curves of GRBs viewed at large angles. Motivated by these results, we consider that GRBs efficiently produce $γ$-rays only within a narrow region around the core. We show that, on these near-core lines-of-sight, structured jets naturally produce shallow phases in the X-ray afterglow of GRBs. These plateaus would be seen by a large fraction of observers and would last between $10^2-10^5$ s. They naturally reproduce the observed distributions of time-scales and luminosities as well as the inter-correlations between plateau duration, plateau luminosity and prompt $γ$-ray energy. An advantage of this interpretation is that it involves no late time energy injection which would be both challenging from the point of view of the central engine and, as we show here, less natural given the observed correlations between plateau and prompt properties.
description: 11 pages, 6 figures. Accepted for publication in MNRAS
Ichneumon coniger TISCHBEIN 1876
Creators: name: Kolarov, J.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Ichneumonidae
Ichneumon
Ichneumon coniger

description: Ichneumon coniger TISCHBEIN 1876
 Ichneumon coniger TISCHBEIN 1876. Stettin Ent. Zeigt. 37: 284.
 Ichneumon coniger: SCHMIEDEKNECHT 1928: 280, Croatia; MEYER 1933: 139, Croatia; ANDERSON & WHITING 1939: 65; CONSTANTINEANU 1959: 393, Croatia; HILPERT 1992: 163.
D i s t r i b u t i o n:Europe.
description: Published as part of Kolarov, J., 2008, A Catalogue of the [former] Yugoslavian Ichneumonidae (Hymenoptera, Insecta), pp. 1585-1739 in Linzer biologische Beiträge 40 (2) on page 1661, DOI: 10.5281/zenodo.5431642
A Retaguarda da Vanguarda - Modernidades contestadas em três tempos: Bilac, Aranha e Lobato.
Creators: Diniz da Silva, Daniella Amaral
Publisher: name: Columbia University
Year: 2015
Subjects: Literature, Modern
Brazilian literature
Brazilian literature--Social aspects
Brazilian literature--Political aspects
Latin Americans
Latin American literature
History

description: This dissertation studies conservative modernism through the work of three Brazilian authors: Olavo Bilac, Graça Aranha and Monteiro Lobato. The three of them lived and were active between the 1890s and 1930s and were influential and controversial public figures during that period. Commonly criticized by the avant-garde modernists, their names remain associated with conservative and traditional views of modernity. I analyze how these three authors dialogued with the literary and journalistic circles and what kind of impact their works had when confronted with the avant-garde generation. I argue that some of their main ideas – misconceived in their attempt to answer the dilemmas of Brazilian society at the time – represented, nevertheless, an opportunity to think about the dialogue between high culture and popular culture, key elements of national identity used in the political discourse, and the role of the writer. These three central issues were tackled in the development and accommodation of modernity in the social and political discourse at that time.
Spatially Averaged Quantum Inequalities Do Not Exist in Four-Dimensional Spacetime
Creators: name: Ford, L. H.
name: Helfer, Adam D.
name: Roman, Thomas A.
Publisher: name: arXiv
Year: 2002
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We construct a particular class of quantum states for a massless, minimally coupled free scalar field which are of the form of a superposition of the vacuum and multi-mode two-particle states. These states can exhibit local negative energy densities. Furthermore, they can produce an arbitrarily large amount of negative energy in a given region of space at a fixed time. This class of states thus provides an explicit counterexample to the existence of a spatially averaged quantum inequality in four-dimensional spacetime.
description: 13 pages, 1 figure, minor corrections and added comments
IMB-XMA0038, a new inhibitor targeting aspartate-semialdehyde dehydrogenase of Mycobacterium tuberculosis
Creators: name: Wang, Xiao
name: Yang, Ruifang
name: Liu, Sihan
name: Guan, Yan
name: Xiao, Chunling
name: Li, Chuanyou
name: Meng, Jianzhou
name: Pang, Yu
name: Liu, Yishuang
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: The emergence of drug-resistant tuberculosis (TB) constitutes a major challenge to TB control programmes. There is an urgent need to develop effective anti-TB drugs with novel mechanisms of action. Aspartate-semialdehyde dehydrogenase (ASADH) is the second enzyme in the aspartate metabolic pathway. The absence of the pathway in humans and the absolute requirement of aspartate in bacteria make ASADH a highly attractive drug target. In this study, we used ASADH coupled with Escherichia coli type III aspartate kinase (LysC) to establish a high-throughput screening method to find new anti-TB inhibitors. IMB-XMA0038 was identified as an inhibitor of MtASADH with an IC50 value of 0.59 μg/mL through screening. The interaction between IMB-XMA0038 and MtASADH was confirmed by surface plasmon resonance (SPR) assay and molecular docking analysis. Furthermore, IMB-XMA0038 was found to inhibit various drug-resistant MTB strains potently with minimal inhibitory concentrations (MICs) of 0.25–0.5 μg/mL. The conditional mutant strain MTB::asadh cultured with different concentrations of inducer (10−5 or 10−1 μg/mL pristinamycin) resulted in a maximal 16 times difference in MICs. At the same time, IMB-XMA0038 showed low cytotoxicity in vitro and vivo. In mouse model, it encouragingly declined the MTB colony forming units (CFU) in lung by 1.67 log10 dosed at 25 mg/kg for 15 days. In conclusion, our data demonstrate that IMB-XMA0038 is a promising lead compound against drug-resistant tuberculosis.
Additional file 4: of Intertumoral heterogeneity in patient-specific drug sensitivities in treatment-naïve glioblastoma
Creators: name: Skaga, Erlend
name: Kulesskiy, Evgeny
name: Fayzullin, Artem
name: Sandberg, Cecilie
name: Swapnil Potdar
name: Kyttälä, Aija
name: Langmoen, Iver
name: Laakso, Aki
name: Gaál-Paavola, Emília
name: Perola, Markus
name: Wennerberg, Krister
name: Vik-Mo, Einar
Publisher: name: figshare
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology

description: Global gene expression analyses. (A) Correspondence analysis of global gene expression data displayed a tumor distribution contrasting the overall drug sensitivity analyses with no clear separation of the two most sensitive tumors from the others. Each dot in the scatter plot represents individual genes (rows), while individual tumors are highlighted (columns). (B) Unsupervised hierarchical clustering with distance matrix (average linkage, Pearson correlation). (PDF 657 kb)
A Riddle, Wrapped in a Mystery, Inside an Enigma: The Formation of a Modern Peacetime U.S. Intelligence Structure, 1943-1949
Creators: Adzhiashvili, Esther
Publisher: name: Columbia University
Year: 2010
Subjects: History

description: By the end of the Second World War, American intelligence organizations were mounting extensive efforts against Soviet communications, despite the official designation of the USSR as an ally. Meanwhile, the USSR never ceased its tradition of espionage, which dated back to tsarist times. However, at the end of the twentieth century, many of the historians who acknowledge the significance of SIGINT (signals intelligence) in the Second World War, ignore intelligence almost completely in their histories of the Cold War. Intelligence is particularly ignored in historiography of the origins of the Cold War. In effort to draw a link between the two scholarships of the Cold War, this thesis, by focusing of the formative period of the Cold War, argues that between 1943 and 1949, intelligence had brief window of opportunity to influence early American policy toward the Soviet Union, but failed to do so as result of internal and external factors.
The EntOptLayout Cytoscape plug-in for the efficient visualization of major protein complexes in protein-protein interaction and signalling networks
Creators: name: Agg, Bence
name: Csaszar, Andrea
name: Szalay-Beko, Mate
name: Veres, Daniel V.
name: Mizsei, Reka
name: Ferdinandy, Peter
name: Csermely, Peter
name: Kovacs, Istvan A.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Molecular Networks (q-bio.MN)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Biological sciences
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Motivation: Network visualizations of complex biological datasets usually result in 'hairball' images, which do not discriminate network modules. Results: We present the EntOptLayout Cytoscape plug-in based on a recently developed network representation theory. The plug-in provides an efficient visualization of network modules, which represent major protein complexes in protein-protein interaction and signalling networks. Importantly, the tool gives a quality score of the network visualization by calculating the information loss between the input data and the visual representation showing a 3- to 25-fold improvement over conventional methods. Availability and implementation: The plug-in (running on Windows, Linux, or Mac OS) and its tutorial (both in written and video forms) can be downloaded freely under the terms of the MIT license from: http://apps.cytoscape.org/apps/entoptlayout. Supplementary data are available at Bioinformatics online. Contact: csermely.peter@med.semmelweis-univ.hu
Interfacing Interpreted and Compiled Languages to Support Applications on a Massively Parallel Network of Workstations (MP-NOW)
Creators: name: Kepner, Jeremy
name: Gokhale, Maya
name: Minnich, Ron
name: Marks, Aaron
name: DeGood, John
Publisher: name: arXiv
Year: 1999
Subjects: subject: Astrophysics (astro-ph)
subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: Astronomers are increasingly using Massively Parallel Network of Workstations (MP-NOW) to address their most challenging computing problems. Fully exploiting these systems is made more difficult as more and more modeling and data analysis software is written in interpreted languages (such as IDL, MATLAB, and Mathematica) which do not lend themselves to parallel computing. We present a specific example of a very simple, but generic solution to this problem. Our example uses an interpreted language (IDL) to set up a calculation and then interfaces with a computational kernel written in a compiled language (C). The IDL code then calls the C code as an external library. We have added to the computational kernel an additional layer, which manages multiple copies of the kernel running on a MP-NOW and returns the results back to the interpreted layer. Our implementation uses The Next generation Taskbag (TNT) library developed at Sarnoff to provide an efficient means for implementing task parallelism. A test problem (taken from Astronomy) has been implemented on the Sarnoff Cyclone computer which consists of 160 heterogeneous nodes connected by a ``fat'' tree 100 Mb/s switched Ethernet running the RedHat Linux and FreeBSD operating systems. Our first results in this ongoing project have demonstrated the feasibility of this approach and produced speedups of greater than 50 on 60 processors.
description: To appear in Cluster Computing, 22 pages including 8 color figures
Additional file 1 of Simplified molecular classification of lung adenocarcinomas based on EGFR, KRAS, and TP53 mutations
Creators: name: Ruiz-Cordero, Roberto
name: Ma, Junsheng
name: Khanna, Abha
name: Lyons, Genevieve
name: Rinsurongkawong, Waree
name: Bassett, Roland
name: Guo, Ming
name: Routbort, Mark
name: Zhang, Jianjun
name: Skoulidis, Ferdinandos
name: Heymach, John
name: Roarty, Emily
name: Tang, Zhenya
name: Medeiros, L.
name: Patel, Keyur
name: Luthra, Rajyalakshmi
name: Roy-Chowdhuri, Sinchita
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Computational Biology

description: Additional file 1. Supplement Data. Materials and Methods.
Ichneumon ligatorius THUNBERG 1824
Creators: name: Kolarov, J.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Ichneumonidae
Ichneumon
Ichneumon ligatorius

description: Ichneumon ligatorius THUNBERG 1824
 Ichneumon ligatorius THUNBERG 1824. Mem. Acad. Sc. St. Petersbourg 8: 277.
 Ichneumon ligatorius: CONSTANTINEANU 1959: 524.
D i s t r i b u t i o n Palearcticregion.
description: Published as part of Kolarov, J., 2008, A Catalogue of the [former] Yugoslavian Ichneumonidae (Hymenoptera, Insecta), pp. 1585-1739 in Linzer biologische Beiträge 40 (2) on page 1662, DOI: 10.5281/zenodo.5431642
A Review of Genetic Transfer Therapy Trials from a Regulatory Perspective for the Scientific Understanding
Creators: Olguin, Arturo
Publisher: name: Columbia University
Year: 2013
Subjects: subject: Medical ethics
subject: Genetics
subject: FOS: Biological sciences

description: The present work reviews the safety and efficacy concerns of the Recombinant DNA Advisory Committee (RAC) regarding Gene Transfer Therapy (GTT) clinical trials. The RAC, an advisory board established by the National Institutes of Health (NIH) is charged with reviewing and discussing GTT clinical trials and give regulatory guidance to the NIH for further proceedings. Considering the infamous past of GTT clinical trials, where malignancies have been found as a serious adverse event, one of the main concerns among regulators is the possible insertional mutagenesis (IM) caused by the viral vector used in this kind of trials. Many controls have been suggested to decrease this risk like fully characterizing the insertion sites (IS) of the vector used. The rest of the regulatory concerns are related to efficacy and safety of the whole therapy. This is no different from any other type of therapy or drug that is subject to FDA approval, however, there are some specific points for GTT clinical trials that must not be ignored. Based on these concerns, I include two case studies to exemplify how their findings would be reviewed from a regulatory perspective The first is a trial that uses an Adenovirus-associated virus vector to treat adult patients suffering from Hemophilia B. The trial is successful but they did not covered key efficacy and safety aspects that would fully convince a regulator to approve this kind of therapy. The second trial uses a lentiviral vector to transduce ex-vivo hematopoietic cells to correct the condition known as X-linked adrenoleukodystrophy (X-ALD), which affects children from 5-12 years of age and results in mental retardation and if not treated can cause death. The researchers on this trial took a lot of measures and controls to ensure the safety of the therapy however they failed to include a statistically significant population that would describe the efficacy of the therapy over the standard of care. I hope this can serve as a guide to harmonize the understanding of regulatory requirements from the science community and work together for a better drug development process.
Supplementary_File - Information Security Analysis in the Passenger-Autonomous Vehicle Interaction
Creators: name: Bakhtina, Mariia
Publisher: name: figshare
Year: 2021
Subjects: subject: 80303 Computer System Security
subject: FOS: Computer and information sciences

description: Supplementary File for Information Security Analysis in the Passenger-Autonomous Vehicle Interaction by Mariia Bakhtina and Raimundas Matulevicius in SP2I ARES 2021 workshop.
Mean-field thermodynamic quantum time-space crystal: spontaneous breaking of time-translation symmetry in a macroscopic fermion system
Creators: name: Efetov, Konstantin B.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: A model demonstrating existence of a thermodynamically stable quantum time-space crystal has been proposed and studied. This state is characterized by an order parameter periodic in both real and imaginary times. The average of the order parameter over phases of the oscillations vanishes but correlation functions of two or more order parameters show non-decaying oscillations. An alternative interpretation of the results is based on a concept of an operator order parameter introduced for this purpose. The model studied here has been suggested previously, in particular, for describing the pseudogap state in superconducting cuprates. Although many properties of the time-space crystal considered here are close to those of a well known DDW state, static magnetic moments oscillating at $ ( π,π) $ do not exist. Instead, $δ$-peaks at finite energies are predicted in the cross-section of inelastic spin-polarized neutron scattering.
description: 33 pages, 3 figures. Many details concerning breaking of time-translation symmetry are added, inapplicability of a `no-go' theorem is explained, the final results remain intact. arXiv admin note: text overlap with arXiv:1902.07520
Loxandrus limatus Casey 1918
Creators: name: Bousquet, Yves
Publisher: name: Zenodo
Year: 2006
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Carabidae
Loxandrus
Loxandrus limatus

description: 12. Loxandrus limatus Casey, 1918:382
This taxon was described from an unspecified number of specimens collected in the « District of Columbia ». Casey’s collection in USNM contains a single specimen, a female herein designated as the lectotype, labelled «Washgtn 15.10 D.C./Casey bequest 1925/Type USNM 47335 / limatus Csy. [handwritten]/ UAIC 00044057 / lectotype Loxandrus limatus by [handwritten] R. T. Allen».
 The lectotype (SBL ¼ 8.9; ABL ¼ about 10.0 mm) is conspecific with specimens of L. rectus (Say, 1823) [NEW SYNONYMY]. As pointed out by Allen (1972:72) ‘‘the large size and broadly rounded and explinate posterior angles of the pronotum serve to distinguish this species [L. rectus] and L. pravitubus from all other Loxandrus species. ’’
description: Published as part of Bousquet, Yves, 2006, New Synonymies and Notes on North American Loxandrus LeConte (Coleoptera: Carabidae), pp. 145-157 in The Coleopterists Bulletin 60 (2) on page 149, DOI: 10.1649/865.1, http://zenodo.org/record/10106359
Supplementary_File - Information Security Analysis in the Passenger-Autonomous Vehicle Interaction: Security requirements for Passenger-AV interaction using SREBP method
Creators: name: Bakhtina, Mariia
Publisher: name: figshare
Year: 2021
Subjects: subject: 80303 Computer System Security
subject: FOS: Computer and information sciences

description: Supplementary File for Information Security Analysis in the Passenger-Autonomous Vehicle Interaction by Mariia Bakhtina and Raimundas Matulevicius in SP2I ARES 2021 workshop.

The file contains a set of security requirements elicited for the Passenger-AV interaction scenario. The elicitation was conducted using the SREBP method.
Ichneumon melanotis HOLMGREN 1864
Creators: name: Kolarov, J.
Publisher: name: Zenodo
Year: 2008
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Ichneumonidae
Ichneumon
Ichneumon melanotis

description: Ichneumon melanotis HOLMGREN 1864
 Ichneumon melanotis HOLMGREN 1864. Ichn. Suec. 1: 72.
 Ichneumon melanotis: HEINRICH 1930: 120, Croatia.
D i s t r i b u t i o n:Palearcticregion.
description: Published as part of Kolarov, J., 2008, A Catalogue of the [former] Yugoslavian Ichneumonidae (Hymenoptera, Insecta), pp. 1585-1739 in Linzer biologische Beiträge 40 (2) on page 1662, DOI: 10.5281/zenodo.5431642
JOHN JOSEPH THOMAS HAYES OWEN - Bibliography from JOHN JOSEPH THOMAS HAYES OWEN. 7 January 1934 — 5 January 2023
Creators: name: Brown, Geoff
name: Michell, Bob
Publisher: name: The Royal Society
Year: 2024
Subjects: classificationCode: 320499
subject: Immunology not elsewhere classified

description: John Owen was an anatomist and immunologist who conducted pioneering work on the origins and development of the two major classes of lymphocytes, the cells that are the central players in the adaptive immune systems of vertebrates. He was a meticulous biological experimenter who liked to keep questions simple and precise. His observations contributed to two key discoveries: that mouse and avian stem cells migrate into the embryonic thymus and give rise to T lymphocytes; and that in birds the Bursa of Fabricius is the tissue in which stem cells develop into B lymphocytes. He also helped to establish that in mammals the earliest B lymphocytes develop in the liver of the fetus. He and his colleagues went on to define how combinations of several cell populations in the thymus provide the settings in which mammals first generate and then select from the variety of T lymphocyte lineages and immune specificities that will equip them with healthy immune surveillance and responses. His wry Liverpudlian sense of humour let him engage easily with everyone, from any walk of life, and he was an inspiration to young colleagues, many of whom would go on to flourish in the research areas that he pioneered. John died on 5 January 2023, from prostate cancer and other ailments: but he was in the gym only a couple of weeks before he died. He is buried in Kirkdale cemetery, Lancashire, under a family tombstone that also celebrates his grandfather, his father and his mother: his epitaph reads ‘One push-up too many’.
Additional file 1 of A meta-analysis of the incidence rate of postoperative acute kidney injury in patients with congenital heart disease
Creators: name: Li, Dandan
name: Niu, Zhaozhuo
name: Huang, Qiang
name: Sheng, Wei
name: Wang, Tianyi
Publisher: name: figshare
Year: 2020
Subjects: Medicine
Biotechnology
Mathematical Sciences not elsewhere classified
Developmental Biology
Science Policy

description: Additional file 1 Table S1 The detailed information relating to the retrieval steps and results of PubMed (The retrieval time: 20200424). Table S2 The detailed information relating to the retrieval steps and results of Embase (The retrieval time: 20200424). Table S3 The detailed information relating to the retrieval steps and results of The Cochrane library (The retrieval time: 20200424)
Theory of spin transport through antiferromagnetic insulator
Creators: name: Tatara, Gen
name: Pauyac, Christian Ortiz
Publisher: name: arXiv
Year: 2019
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: A theoretical formulation for spin transport through an antiferromagnetic (AF) insulator is presented in the case driven/detected by direct/inverse spin Hall effect in two heavy metal contacts. The spin signal is shown to be transferred by the ferromagnetic correlation function of the antiferromagnet, which is calculated based on a magnon representation. To cover high temperature regimes, we include an auxiliary field representing short AF correlations and a temperature-dependent damping due to magnon scattering. The diffusion length for spin is long close to the degeneracy of the two AF magnons, and has a maximum as function of temperature near the Néel transition.
Suppression of Entropy Perturbations in Multi--Field Inflation on the Brane
Creators: name: Ashcroft, P. R.
name: van de Bruck, C.
name: Davis, A. -C.
Publisher: name: arXiv
Year: 2002
Subjects: subject: Astrophysics (astro-ph)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: At energies higher than the brane tension, the dynamics of a scalar field rolling down a potential are modified relative to the predictions of General Relativity. The modifications imply, among other things, that steeper potentials can be used to drive an epoch of slow--roll inflation. We investigate the evolution of entropy and adiabatic modes during inflation driven by two scalar fields confined on the brane. We show that the amount of entropy perturbations produced during inflation is suppressed compared to the predictions made by General Relativity. As a consequence, the initial conditions do not matter in multiple field inflation in brane worlds if inflation is driven at energies much higher than the brane tension.
description: 4 pages, 1 figure