The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
Creators: name: Laakso, Markku
name: Kleber, Marcus E.
name: Kim, Yun Kyoung
name: Schwarz, Peter E. H.
name: Holmen, Jostein
name: Lindström, Jaana
name: Franceschini, Nora
name: Krauss, Ronald M.
name: Peters, Annette
name: Wu, Ying
name: Bonnycastle, Lori L.
name: Smith, Albert V.
name: Munroe, Patricia B.
name: Stančáková, Alena
name: Hunt, Steven C.
name: Tarasov, Kirill V.
name: Farrall, Martin
name: Ridker, Paul M.
name: Fornage, Myriam
name: Balkau, Beverley
name: Renström, Frida
name: Groves, Christopher J.
name: Chang, I-Shou
name: Bjornsdottir, Gyda
name: Gierman, Hinco J.
name: Fall, Tove
name: Saltevo, Juha
name: O'Reilly, Paul F.
name: Bochud, Murielle
name: Shah, Sonia
name: Khaw, Kay-Tee
name: Brown, Morris J.
name: Amin, Najaf
name: Deloukas, Panos
name: Jarvelin, Marjo-Riitta
name: März, Winfried
name: Lakka, Timo A.
name: Goel, Anuj
name: Penninx, Brenda W.
name: Edkins, Sarah
name: Montasser, May E.
name: Paccaud, Fred
name: Markus, Hugh S.
name: Hsiung, Chao A.
name: Wagner, Aline
name: Spector, Tim D.
name: Meneton, Pierre
name: Bornstein, Stefan R.
name: Iribarren, Carlos
name: Chen, Yii-Der I.
name: Mulas, Antonella
name: Kim, Stuart K.
name: Watkins, Hugh
name: De Faire, Ulf
name: Ferrucci, Luigi
name: Rasheed, Asif
name: Fava, Cristiano
name: Verwoert, Germaine C.
name: Goodall, Alison H.
name: Caulfield, Mark J.
name: Thorleifsson, Gudmar
name: Kang, Hyun Min
name: Joehanes, Roby
name: Kolovou, Genovefa
name: Wilsgaard, Tom
name: Barroso, Inês
name: Petersen, Ann-Kristin
name: Cheng, Ching-Yu
name: Evangelou, Evangelos
name: Esko, Tonu
name: Delgado, Graciela
name: Hayward, Caroline
name: Axelsson, Tomas
name: Franco, Oscar H.
name: Sheu, Wayne H.-H.
name: Vitart, Veronique
name: Westra, Harm-Jan
name: Sanna, Serena
name: Li, Xiaohui
name: Morris, Andrew P.
name: Uitterlinden, Andre G.
name: Voight, Benjamin F.
name: Virtamo, Jarmo
name: Chung, Ren-Hua
name: Sim, Xueling
name: Langenberg, Claudia
name: Morrison, Alanna C.
name: Taylor, Kent D.
name: Hottenga, Jouke-Jan
name: Vaez, Ahmad
name: Ikram, M Arfan
name: Müller-Nurasyid, Martina
name: Hicks, Andrew A.
name: Wong, Tien Y.
name: Smith, Andrew J. P.
name: Hingorani, Aroon D.
name: Stirrups, Kathleen E.
name: Bandinelli, Stefania
name: Connell, John M.
name: Hallmans, Göran
name: Willer, Cristen J.
name: Keating, Brendan J.
name: Loos, Ruth J. F.
name: Rauramaa, Rainer
name: Gianfagna, Francesco
name: Boerwinkle, Eric
name: Ong, Ken K.
name: Wilson, James F.
name: Palmas, Walter
name: Burnier, Michel
name: Wareham, Nicholas J.
name: Franks, Paul W.
name: Kim, Eric
name: Herzig, Karl-Heinz
name: Rayner, N William
name: Yao, Jie
name: Evans, Alun
name: Zhao, Jing Hua
name: Franco-Cereceda, Anders
name: Thorsteinsdottir, Unnur
name: Lehtimäki, Terho
name: Ingelsson, Erik
name: Marouli, Eirini
name: Gertow, Karl
name: Hartikainen, Anna-Liisa
name: Sever, Peter
name: Psaty, Bruce M.
name: Lee, I-Te
name: Witkowska, Kate
name: Ferreira, Teresa
name: Salomaa, Veikko
name: Zhao, Wei
name: Holmen, Oddgeir Lingaas
name: Sundstrom, Johan
name: Menni, Cristina
name: Nikus, Kjell
name: Kvaløy, Kirsti
name: Kosova, Gulum
name: Kuulasmaa, Kari
name: Kathiresan, Sekar
name: Lind, Lars
name: Elosua, Roberto
name: Sosa, Maria X.
name: Rice, Kenneth M.
name: Stefansson, Kari
name: Wilks, Rainford
name: Lataniotis, Lazaros
name: O'Donnell, Christopher J.
name: Erdmann, Jeanette
name: Kanoni, Stavroula
name: Forrester, Terrence
name: Barnes, Michael R.
name: Hughes, Maria F.
name: Kähönen, Mika
name: Havulinna, Aki S.
name: Rose, Lynda M.
name: Tobin, Martin D.
name: Donnelly, Louise A.
name: Weder, Alan B.
name: Vasan, Ramachandran S.
name: Yengo, Loic
name: Gorski, Mathias
name: Sebert, Sylvain
name: Mach, François
name: Shungin, Dmitry
name: Tanaka, Toshiko
name: Mohlke, Karen L.
name: Ehret, Georg B.
name: Kaakinen, Marika
name: Metspalu, Andres
name: Klopp, Norman
name: Folkersen, Lasse
name: Zhu, Xiaofeng
name: Eriksson, Niclas
name: Ferrières, Jean
name: Schunkert, Heribert
name: Kivimaki, Mika
name: Kuusisto, Johanna
name: Jensen, Richard A.
name: Salfati, Elias L.
name: Theusch, Elizabeth
name: Swift, Amy J.
name: Van Duijn, Cornelia M.
name: Syvänen, Ann-Christine
name: Lakatta, Edward G.
name: Wichmann, H-Erich
name: Van Iperen, Erik P. A.
name: Jackson, Anne U.
name: Kooner, Jaspal S.
name: Shin, Young-Ah
name: Nagaraja, Ramaiah
name: Cooper, Richard S.
name: Tuomilehto, Jaakko
name: Levy, Daniel
name: Melander, Olle
name: Wain, Louise V.
name: Tai, E-Shyong
name: Gräßler, Jürgen
name: Adair, Linda S.
name: Gyllensten, Ulf
name: Müller, Gabriele
name: McKenzie, Colin A.
name: Enroth, Stefan
name: Njølstad, Inger
name: Parsa, Afshin
name: Nolte, Ilja M.
name: Tayo, Bamidele O.
name: Dallongeville, Jean
name: Hveem, Kristian
name: Snieder, Harold
name: Lyytikäinen, Leo-Pekka
name: Rettig, Rainer
name: Vollenweider, Peter
name: Gao, He
name: Giulianini, Franco
name: Goodarzi, Mark O.
name: Hamsten, Anders
name: Gigante, Bruna
name: Cabrera, Claudia P.
name: Pedersen, Nancy L.
name: Lee, Nanette R.
name: Quertermous, Thomas
name: Danesh, John
name: Bevan, Stephen
name: Narisu, Narisu
name: Hercberg, Serge
name: Palmer, Cameron D.
name: Eicher, John D.
name: McCarthy, Mark I.
name: Doney, Alex S. F.
name: Pihur, Vasyl
name: Tremoli, Elena
name: Poulter, Neil
name: Moilanen, Leena
name: Samani, Nilesh J.
name: Komulainen, Pirjo
name: Felix, Janine F.
name: Assimes, Themistocles L.
name: Liang, Kae-Woei
name: Smit, Johannes H.
name: Magnusson, Patrik K.
name: Howard, Phil
name: Saramies, Jouko
name: Lee, Jong-Young
name: Dedoussis, George
name: Teumer, Alexander
name: Chambers, John C.
name: Morris, Andrew D.
name: Zhang, Weihua
name: Chakravarti, Aravinda
name: Elliott, Paul
name: Froguel, Philippe
name: Palmer, Colin N. A.
name: Johnson, Toby
name: Franke, Lude
name: Rossouw, Jacques
name: Rotter, Jerome I.
name: Lin, Li
name: Wong, Andrew
name: Fraser, Ross M.
name: Hofman, Albert
name: Kristiansson, Kati
name: Chines, Peter S.
name: Uusitupa, Matti
name: Boehnke, Michael
name: Pers, Tune H.
name: Vaidya, Dhananjay
name: Arking, Dan E.
name: Eriksson, Per
name: Boomsma, Dorret I.
name: Gudnason, Vilmundur
name: Lobbens, Stéphane
name: Schmidt, Ellen M.
name: Kumari, Meena
name: Bis, Joshua C.
name: Perola, Markus
name: Jansen, Rick
name: Bovet, Pascal
name: Döring, Angela
name: Stringham, Heather M.
name: Chasman, Daniel I.
name: Kim, Young Jin
name: Collins, Francis S.
name: Absher, Devin
name: Pramstaller, Peter P.
name: Newton-Cheh, Christopher
name: Yang, Tsun-Po
name: Ganesh, Santhi K.
name: Rao, Dabeeru C.
name: Männistö, Satu
name: Stanton, Alice V.
name: Saleheen, Danish
name: Hirschhorn, Joel N.
name: Dominiczak, Anna F.
name: Guo, Xiuqing
name: Baldassarre, Damiano
name: Drenos, Fotios
name: Illig, Thomas
name: Johnson, Andrew D.
name: Luan, Jian'An
name: Hovingh, G. Kees
name: Kuh, Diana
name: Kutalik, Zoltan
name: Strawbridge, Rona J.
name: Warren, Helen
name: Lee, Wen-Jane
name: Bouatia-Naji, Nabila
name: Lin, Honghuang
name: Mijatovic, Vladan
name: Roberts, Robert
name: Rallidis, Loukianos S.
name: Hassinen, Maija
name: Meirelles, Osorio
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: To dissect the genetic architecture of blood pressure and assess effects on target-organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure loci, of which 17 were novel and 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target-organ damage in multiple tissues, with minor effects in the kidney. Our findings expand current knowledge of blood pressure pathways and highlight tissues beyond the classic renal system in blood pressure regulation.