cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Heraldry on the tombs of Margaret, Countess of Cumberland, and Anne, Countess of Pembroke, Dorset and Montgomery, in St Lawrence's, Appleby.
Creators: name: Boumphrey, R S
Publisher: name: Archaeology Data Service
Year: 2017

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 74, 221-222
Strukturbiologie der systemischen Amyloidosen
Creators: name: Haupt, Christian
name: Schmidt, Matthias
name: Fändrich, Marcus
Publisher: name: Universität Ulm
Year: 2024
Subjects: subject: DDC 570 / Life sciences
subject: Amyloidosis
subject: Amyloidose

description: Systemic amyloidosis refers to a group of diseases that are caused by the misfolding of proteins and their deposition as amyloid fibrils in various organs. Here we present an overview of the progress made in the understanding of the biochemical and structural characteristics of the pathogenic agents of these diseases, obtained by using cryo-electron microscopy. The observed structures provided insights in the molecular etiology of the diseases and helped to shed light on the mechanism of misfolding in the affected patients.
Additional file 1 of Mind the gap: covariate constrained randomisation can protect against substantial power loss in parallel cluster randomised trials
Creators: name: Kristunas, Caroline
name: Grayling, Michael
name: Gray, Laura J.
name: Hemming, Karla
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Appendix Figure 1. Type I error rate when fourcovariates are balanced in the randomisation (C=4) and an increasing number ofcovariates (A≤C) are adjusted in the analysis.
Serum IGF1 and linear growth in children with congenital leptin deficiency before and after leptin substitution
Creators: name: Beghini, Marianna
name: Brandt, Stephanie
name: Körber, Ingrid
name: Kohlsdorf, Katja
name: Vollbach, Heike
name: Lennerz, Belinda
name: Denzer, Christian
name: Shalitin, Shlomit
name: Santini, Ferruccio
name: Blum, Werner F.
name: Von Schnurbein, Julia
name: Wabitsch, Martin
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Endocrine system and metabolic diseases
subject: Obesity
subject: BINDING-PROTEIN (IGFBP)-1
subject: EARLY-ONSET OBESITY
subject: FACTOR-I
subject: MISSENSE MUTATION
subject: WEIGHT-LOSS
subject: REFERENCE INTERVALS
subject: POTENT STIMULATOR
subject: FACTOR (IGF)-I
subject: BONE TURNOVER
subject: INSULIN
subject: DDC 610 / Medicine & health

description: Abstract Background Evidence from in vitro and rodent studies suggests that leptin, a key signal of long-term energy reserves, promotes IGF1 synthesis and linear growth. This effect of leptin has not been fully investigated in humans. The aim of our study was to investigate the effect of leptin substitution on growth factors and linear growth in children with congenital leptin deficiency (CLD). Methods In this cohort study we included eight pediatric patients (six males), age 0.9–14.8 years, who were diagnosed with CLD and received leptin substitution at our University Medical Center. We calculated standard deviation scores (SDS) for serum levels of IGF1 and IGFBP3, IGF1/IGFBP3 molar ratio, and height at baseline (T0) and 12 months (T12) after the initiation of substitution with metreleptin. Results All patients had severe obesity (BMI-SDS mean ± SD: 4.14 ± 1.51) at T0 and significant BMI-SDS reduction to 2.47 ± 1.05 at T12. At T0, all patients were taller than the mid-parental median, yet had low IGF1 and IGF1/IGFBP3 molar ratios (IGF1-SDSx¯\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\overline x$$\end{document}T0: −1.58 ± 0.92, IGF1/IGFBP3 molar ratio-SDSx¯\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\overline x$$\end{document}T0: −1.58 ± 0.88). At T12, IGF1-SDS increased significantly (∆T0–12: 1.63 ± 1.40, p = 0.01), and IGFBP3-SDS and IGF1/IGFBP3 molar ratio-SDS showed a trend toward an increase. In the three children within the childhood growth period (post-infancy, pre-puberty) height-SDS increased (∆height-SDST0–12: 0.57 ± 0.06, p = 0.003) despite substantial weight loss. Conclusions These results in CLD patients are contrary to observations in children with idiopathic obesity who typically have above-mean IGF1 levels that decrease with weight loss, and therefore suggest that leptin increases IGF1 levels and promotes linear growth.
Additional file 2 of Mind the gap: covariate constrained randomisation can protect against substantial power loss in parallel cluster randomised trials
Creators: name: Kristunas, Caroline
name: Grayling, Michael
name: Gray, Laura J.
name: Hemming, Karla
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2: Table 1. Power by candidate set size when an increasing number of covariates (C) are balanced in the randomisation and the same number of covariates are adjusted in the analysis, for trials with 10 clusters and intracluster correlation coefficient (ICC) between 0.001 and 0.1. Table 2. Power by candidate set size when an increasing number of covariates (C) are balanced in the randomisation and the same number of covariates are adjusted in the analysis, for trials with 18 clusters and intracluster correlation coefficient (ICC) between 0.001 and 0.1. Table 3. Power by candidate set size when an increasing number of covariates (C) are balanced in the randomisation and the same number of covariates are adjusted in the analysis, for trials with 26 clusters and intracluster correlation coefficient (ICC) between 0.001 and 0.1.
НЕТРАДИЦИОННЫЙ ИСТОЧНИК ЭНЕРГИИ НА ОСНОВЕ НАНОКОМПОЗИТОВ
Creators: name: Исаев, Х.
name: Боймуратов, Ф.Т.
Publisher: name: Zenodo
Year: 2024

description: Разработка  нетрадиционных источников энергии является  одной из  основных задач энергетики Узбекистана. Развитие топливно-энергетического комплекса в сфере энергетики Республики невозможно без создания новых технологий и новых  материалов со специальными электрофизическими свойствами. В последние годы количество экспериментальных и теоретических исследований  в области создания  материалов со специальными и практически важными электрофизическими свойствами  на основе неоднородных материалов, содержащих наночастицы металлов,  значительно расширились, в основном из-за уникальных  физических характеристик  этих композитов, существенно отличных от свойств  соответствующих компактных материалов.
Evaluation of the metabolism, bioactivation and pharmacokinetics of triaminopyrimidine analogs toward selection of a potential candidate for antimalarial therapy
Creators: name: Abhishek Srivastava
name: Vijender Panduga
name: Ramanatha Saralaya
name: Prabhakar K., R.
name: Shahul Hameed
name: Solapure, Suresh
name: Vinayak P. Hosagrahara
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: 1. During the course of metabolic profiling of lead Compound 1, glutathione (GSH) conjugates were detected in rat bile, suggesting the formation of reactive intermediate precursor(s). This was confirmed by the identification of GSH and N-acetylcysteine (NAC) conjugates in microsomal incubations. 2. It was proposed that bioactivation of Compound 1 occurs via the formation of a di-iminoquinone reactive intermediate through the involvement of the C-2 and C-5 nitrogens of the pyrimidine core. 3. To further investigate this hypothesis, structural analogs with modifications at the C-5 nitrogen were studied for metabolic activation in human liver microsomes supplemented with GSH/NAC. 4. Compounds 1 and 2, which bear secondary nitrogens at the C-5 of the pyrimidine core, were observed to form significant amounts of GSH/NAC-conjugates in vitro, whereas compounds with tertiary nitrogens at C-5 (Compound 3 and 4) formed no such conjugates. 5. These observations provide evidence that electron/hydrogen abstraction is required for the bioactivation of the triaminopyrimidines, potentially via a di-iminoquinone intermediate. The lack of a hydrogen and/or steric hindrance rendered Compound 3 and 4 incapable of forming thiol conjugates. 6. This finding enabled advancement of compound 4, with a desirable potency, safety and PK profile, as a lead candidate for further development in the treatment of malaria.
MAKTABGACHA YOSHDAGI BOLALARDA NUTQINI RIVOJLANTIRISHNING PEDAGOGIK USULLARI.
Creators: name: Sulaymonova, Ozoda
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqolada maktabgacha yoshdagi bolalarning nutqini rivojlantirishning pedagogik usullari haqida fikr bildirilgan.
Additional file 3 of Mind the gap: covariate constrained randomisation can protect against substantial power loss in parallel cluster randomised trials
Creators: name: Kristunas, Caroline
name: Grayling, Michael
name: Gray, Laura J.
name: Hemming, Karla
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 3: Table 1. Power by candidate set size when an increasing number of covariates (C) are balanced in the randomisation and all four covariates are adjusted in the analysis, for trials with 10 clusters and intracluster correlation coefficient (ICC) between 0.001 and 0.1 Table 2. Power by candidate set size when an increasing number of covariates (C) are balanced in the randomisation and all four covariates are adjusted in the analysis, for trials with 18 clusters and intracluster correlation coefficient (ICC) between 0.001 and 0.1. Table 3. Power by candidate set size when an increasing number of covariates (C) are balanced in the randomisation and all four covariates are adjusted in the analysis, for trials with 26 clusters and intracluster correlation coefficient (ICC) between 0.001 and 0.1.
Highly sensitive hydrogen sulfide sensor based on GaN/GaInN heterostructure
Creators: name: Shahbaz, Jassim
name: Scholz, Ferdinand
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: GaInN
subject: GaN
subject: Gas sensors
subject: Breath biomarkers
subject: Disease
subject: DDC 530 / Physics
subject: DDC 620 / Engineering & allied operations
subject: Ammonia
subject: Hydrogen sulfide
subject: Ammoniak
subject: Gas

description: Accurate detection of gases such as hydrogen sulfide in the exhaled human breath is of great interest for medical professionals as it can possibly help in the early detection of organ malfunction and other diseases. GaInN heterostructure sensors are sensitive to the changes in the surface potential caused by the adsorption of gas molecules. A quantum well (QW) placed close to the surface experiences a change in the quantum-confined Stark effect and as a result shifts its photoluminescence signal. Several parameters of the GaInN sensors grown by metal organic vapor phase epitaxy are optimized such as the GaN cap layer, QW thickness, and doping concentration. Moreover, how various metal functionalization layers can improve its sensitivity and selectivity is investigated. Gold (Au) and Silver (Ag) shows sensitivity to hydrogen sulfide in the 10–100 parts per billion (ppb) range. Ammonia gas is also detected in the 5–10 range (ppm) with a sensor structure covered with a thin gold layer.
Additional file 4 of Mind the gap: covariate constrained randomisation can protect against substantial power loss in parallel cluster randomised trials
Creators: name: Kristunas, Caroline
name: Grayling, Michael
name: Gray, Laura J.
name: Hemming, Karla
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 4.
Self-supervised pre-training with contrastive and masked autoencoder methods for dealing with small datasets in deep learning for medical imaging
Creators: name: Wolf, Daniel
name: Payer, Tristan
name: Lisson, Catharina Silvia
name: Beer, Meinrad
name: Götz, Michael
name: Ropinski, Timo
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: Computer science
subject: Machine learning
subject: Medical imaging
subject: DDC 000 / Computer science, information & general works

description: Deep learning in medical imaging has the potential to minimize the risk of diagnostic errors, reduce radiologist workload, and accelerate diagnosis. Training such deep learning models requires large and accurate datasets, with annotations for all training samples. However, in the medical imaging domain, annotated datasets for specific tasks are often small due to the high complexity of annotations, limited access, or the rarity of diseases. To address this challenge, deep learning models can be pre-trained on large image datasets without annotations using methods from the field of self-supervised learning. After pre-training, small annotated datasets are sufficient to fine-tune the models for a specific task. The most popular self-supervised pre-training approaches in medical imaging are based on contrastive learning. However, recent studies in natural image processing indicate a strong potential for masked autoencoder approaches. Our work compares state-of-the-art contrastive learning methods with the recently introduced masked autoencoder approach “SparK” for convolutional neural networks (CNNs) on medical images. Therefore, we pre-train on a large unannotated CT image dataset and fine-tune on several CT classification tasks. Due to the challenge of obtaining sufficient annotated training data in medical imaging, it is of particular interest to evaluate how the self-supervised pre-training methods perform when fine-tuning on small datasets. By experimenting with gradually reducing the training dataset size for fine-tuning, we find that the reduction has different effects depending on the type of pre-training chosen. The SparK pre-training method is more robust to the training dataset size than the contrastive methods. Based on our results, we propose the SparK pre-training for medical imaging tasks with only small annotated datasets.
Pazopanib in advanced vascular sarcomas: an EORTC Soft Tissue and Bone Sarcoma Group (STBSG) retrospective analysis
Creators: name: A. Kollár
name: R. L. Jones
name: S. Stacchiotti
name: H. Gelderblom
name: M. Guida
name: G. Grignani
name: N. Steeghs
name: A. Safwat
name: D. Katz
name: F. Duffaud
name: S. Sleijfer
name: W. T. Van Der Graaf
name: N. Touati
name: S. Litière
name: S. Marreaud
name: A. Gronchi
name: B. Kasper
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Background: Pazopanib is a multitargeted tyrosine kinase inhibitor approved for the treatment of patients with selective subtypes of advanced soft tissue sarcoma (STS) who have previously received standard chemotherapy including anthracyclines. Data on the efficacy in vascular sarcomas are limited. The main objective of this study was to investigate the activity of pazopanib in vascular sarcomas. Patients and methods: A retrospective study of patients with advanced vascular sarcomas, including angiosarcoma (AS), epithelioid hemangioendothelioma (HE) and intimal sarcoma (IS) treated with pazopanib in real life practice at EORTC centers as well as patients treated within the EORTC phase II and III clinical trials (62043/62072) was performed. Patient and tumor characteristics were collected. Response was assessed according to RECIST 1.1. and survival analysis was performed. Results: Fifty-two patients were identified, 40 (76.9%), 10 (19.2%) and two (3.8%) with AS, HE and IS, respectively. The response rate was eight (20%), two (20%) and two (100%) in the AS, HE and IS subtypes, respectively. There was no significant difference in response rate between cutaneous and non-cutaneous AS and similarly between radiation-associated and non-radiation-associated AS. Median progression-free survival (PFS) and median overall survival (OS; from commencing pazopanib) were three months (95% CI 2.1–4.4) and 9.9 months (95% CI 6.5–11.3) in AS, respectively. Conclusion: The activity of pazopanib in AS is comparable to its reported activity in other STS subtypes. In this study, the activity of pazopanib was similar in cutaneous/non-cutaneous and in radiation/non-radiation-associated AS. In addition, pazopanib showed promising activity in HE and IS, worthy of further evaluation.
title: OFROM: interview avec unine15a91m
Creators: name: Delafontaine, François
name: Widmer, Aline
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.6d6443jo.v2#116ebfdc40b1bfbd36d0098d1268199551f9f0fa
Informal care-giving and the intention to give up employment: the role of perceived supervisor behaviour in a cohort of German employees
Creators: name: Montano, Diego
name: Peter, Richard
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Informal long-term care
subject: Employment of care-givers
subject: Working conditions
subject: Psychosocial load
subject: Work-private-life conflict
subject: FUTURE TIME PERSPECTIVE
subject: OLDER-PEOPLE
subject: WORK
subject: CAREGIVERS
subject: PARTICIPATION
subject: ASSOCIATIONS
subject: METAANALYSIS
subject: STRESS
subject: BURDEN
subject: HEALTH
subject: DDC 610 / Medicine & health

description: Abstract Current social policies in the European Union addressing employment, retirement and long-term care are expected to result in increasing employment rates among informal carers. The present investigation contributes to previous research by focusing on how specific work-related factors, in this case supervisor behaviour, may facilitate the fulfilment of the demands arising from paid work and care and ultimately influence the desire to give up employment. To this end, population data from the German Cohort Study on Work, Age, Health and Work Participation conducted in 2011 and 2014 are analysed (n = 3916). Three research hypotheses investigating the associations between care-giving, supervisor behaviour, the intention to give up employment and work-private-life conflict are tested by means of cumulative link models. The results suggest that the intention to give up employment is stronger among employed carers. In addition, the perception that one’s supervisor is considerate towards subordinates and is effective in planning, coordinating work and solving conflicts is found to be negatively related to the desire to give up employment, especially among carers. The statistical analyses reveal that supervisor behaviour mediates the association between the level of work-private-life conflict and the intention to give up employment. It is concluded that the working conditions may exert a substantial influence on the levels of psychosocial load carers experience by facilitating or hindering the extent to which carers are allowed to accommodate their work schedules and job assignments to the conflicting demands of their dual role as workers and carers.
Highly Cited Researchers 2014 and 2015: An investigation of some of the world’s most influential scientific minds on the institutional and country level
Creators: name: Bornmann, Lutz
name: Bauer, Johann
name: Schlagberger, Elisabeth Maria
Publisher: name: figshare
Year: 2016
Subjects: subject: Library and Information Studies
subject: FOS: Media and communications

description: For several years, Clarivate Analytics, formerly the IP & Science business of Thomson Reuters, has published a list of researchers who have published the largest number of highly cited papers in a particular discipline (see www.highlycited.com). These researchers are described by Clarivate Analytics as highly-cited researchers (HCRs) or as some of the world's most influential scientific minds. Whereas the HCR 2014 list refers to the publication years 2002 to 2012, the HCR 2015 list which was published a few months ago refers to the years 2003 to 2013. The new list contains a total of 3126 researchers worldwide. Compared with the HCR 2014 list which includes 3215 researchers, the new list thus includes 89 fewer researchers as HCRs. This study undertakes a comparison of HCR 2014 and 2015 on the institute and country levels. As the results on the countries show, for HCR 2015, around half the researchers work in the USA; a further ~10% in Great Britain. About 6% or 5% of the researchers are in Germany or China respectively. In comparison with HCR 2014, no country has lost as many HCRs as the USA with 3.4%. An especially great increase in HCRs occurred in Australia (1.3%), Saudi Arabia (0.7%), Germany (0.5%) and Great Britain (0.5%). The evaluation of the institutional addresses proves that - based on the primary addresses - the largest number of HCRs is employed at the University of California, System (n=161). This is followed by Harvard University (n=95). However, both institutions are also - if one compares HCR 2015 with HCR 2014 - affected by a large decrease in the HCRs (both in numbers of HCR and percentages).
New mono-ether of glycerol and triterpenes with DPPH radical scavenging activity from Cameroonian propolis
Creators: name: Talla, Emmanuel
name: Tamfu, Alfred Ngenge
name: Gade, Isaac Sylvère
name: Yanda, Lambert
name: Mbafor, Joseph Tanyi
name: Laurent, Sophie
name: Elst, Luce Vander
name: Popova, Milena
name: Vassya Bankova
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Inorganic Chemistry
subject: Plant Biology
subject: FOS: Biological sciences

description: The extracts of some propolis samples were analysed by GC-MS and then purified by column chromatography. The latter led to the isolation of a new mono-ether of glycerol, 1′-O-eicosanyl glycerol and a new triterpene, methyl-3β,27-dihydroxycycloart-24-en-26-oate together with known triterpenoids namely betulin, 3β-hydroxylanostan-9,24-dien-21-oic acid, mangiferonic acid, a mixture of ambolic acid and β-sitosterol, 3β-hydroxycycloartan-12,24(25)-diene and 27-hydroxymangiferonic acid. The DPPH radical scavenging potential of some extracts and compounds were measured. The radical scavenging activity varied from Hexane extract of Foumban propolis (IC50 = 5.6 mg/mL) to Methanol extract of Foumban propolis (IC50 = 1.07 mg/mL) for the extracts and from 3β-hydroxylanostan-9,24-dien-21-oic acid (IC50 = 1.22 mg/mL) to 1′-O-eicosanyl glycerol (IC50 = 0.93 mg/mL) for the compounds. Activities of samples were moderate as they remained closer to those of the standard antioxidants Gallic acid (IC50 = 0.30 mg/mL) and vitamin C (IC50 = 0.80 mg/mL), especially 1′-O-eicosanyl glycerol, the most active compound.
The dynamics of ‘First Lady public diplomacy’
Creators: name: Marczuk, Karina Paulina
Publisher: name: figshare
Year: 2022
Subjects: subject: 160607 International Relations
subject: FOS: Political science
subject: 160699 Political Science not elsewhere classified
subject: 200199 Communication and Media Studies not elsewhere classified
subject: FOS: Media and communications

description: This paper was prompted by the growing interest in the role and impact first ladies have on how contemporary states achieve their foreign policy goals through diplomatic means. Specifically, the paper’s purpose is to examine whether and how first ladies are involved in the public diplomacy of their states. The literature on this subject is limited, and this paper therefore aims to fill that gap. The argument is that the traditional role of the first lady has evolved – from one outside of any political-oriented activity to one that increasingly involves diplomatic activities, including promoting the respective countries overseas. The main research questions are whether and how any first ladies are involved in public diplomacy activities, and, if so, what are the main areas and directions in which they are involved, and what is the extent of their action? To answer these questions, the paper presents an exploratory, longitudinal single case study about the role and activities of the present First Lady of Poland, Agata Kornhauser-Duda, during the first term of President Andrzej Duda from August 2015 to August 2020. The intention is to both deconstruct and construct a pattern of what we might call ‘first-lady public diplomacy’.
title: OFROM: interview avec unine15a90m
Creators: name: Delafontaine, François
name: Widmer, Aline
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2023
Subjects: subject: Français
subject: fra

description: Conforms to: Praat textgrid
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Conforms to: doi:10.34847/cocoon.69c4fa74-f324-3ddb-9f1a-580867fd5826
description: Source: https://nakala.fr/10.34847/nkl.ab92tf55.v2#3a07cec0208f1d27f739ff0e174c94c0bcaa3cd8
Additional file 10 of Single-cell RNA sequencing of the retina in a model of retinitis pigmentosa reveals early responses to degeneration in rods and cones
Creators: name: Karademir, Duygu
name: Todorova, Vyara
name: Ebner, Lynn J. A.
name: Samardzija, Marijana
name: Grimm, Christian
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 10: Figure S3. Expression levels of potential target genes after downregulation of Egr1 in vitro. Expression levels of Egr1, potential EGR1-target genes (Agtpbp1, Gadd45b) and a non-target gene (Apoe) were determined in 661W cells 24 hours after transfection of an siRNA against Egr1 (“siEgr1”, blue) or control siRNA (“siCtrl”, green), or in untransfected controls (“No TF”, red). Shown are the mean of three independent experiments (diamonds) ± standard error of the mean (error bars). Each individual point refers to the mean of an independent experiment. *: p < 0.05; one-way ANOVA with Tukey’s range test. TF: transfection.
Semiparametric estimation of moment condition models with weakly dependent data
Creators: name: Bravo, Francesco
name: Chu, Ba M.
name: Jacho-Chávez, David T.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Science Policy
subject: Plant Biology

description: This paper develops the asymptotic theory for the estimation of smooth semiparametric generalized estimating equations models with weakly dependent data. The paper proposes new estimation methods based on smoothed two-step versions of the generalised method of moments and generalised empirical likelihood methods. An important aspect of the paper is that it allows the first-step estimation to have an effect on the asymptotic variances of the second-step estimators and explicitly characterises this effect for the empirically relevant case of the so-called generated regressors. The results of the paper are illustrated with a partially linear model that has not been previously considered in the literature. The proofs of the results utilise a new uniform strong law of large numbers and a new central limit theorem for U-statistics with varying kernels that are of independent interest.
Disruption of orbitofrontal-hypothalamic projections in a murine ALS model and in human patients
Creators: name: Bayer, David
name: Antonucci, Stefano
name: Müller, Hans-Peter
name: Saad, Rami
name: Dupuis, Luc
name: Rasche, Volker
name: Böckers, Tobias M.
name: Ludolph, Albert C.
name: Kassubek, Jan
name: Roselli, Francesco
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: rAAV2
subject: Agranular insula
subject: Orbitofrontal cortex
subject: Lateral hypothalamus
subject: Hypermetabolism
subject: Amyotrophic lateral sclerosis
subject: AMYOTROPHIC-LATERAL-SCLEROSIS
subject: PREFRONTAL CORTICAL PROJECTIONS
subject: BODY-MASS INDEX
subject: PTDP-43 PATHOLOGY
subject: ORBITAL CORTEX
subject: FOOD-INTAKE
subject: BRAIN
subject: CONNECTIVITY
subject: MICE
subject: PROTEIN
subject: DDC 610 / Medicine & health

description: Abstract Background Increased catabolism has recently been recognized as a clinical manifestation of amyotrophic lateral sclerosis (ALS). The hypothalamic systems have been shown to be involved in the metabolic dysfunction in ALS, but the exact extent of hypothalamic circuit alterations in ALS is yet to be determined. Here we explored the integrity of large-scale cortico-hypothalamic circuits involved in energy homeostasis in murine models and in ALS patients. Methods The rAAV2-based large-scale projection mapping and image analysis pipeline based on Wholebrain and Ilastik software suites were used to identify and quantify projections from the forebrain to the lateral hypothalamus in the SOD1(G93A) ALS mouse model (hypermetabolic) and the FusΔNLS ALS mouse model (normo-metabolic). 3 T diffusion tensor imaging (DTI)-magnetic resonance imaging (MRI) was performed on 83 ALS and 65 control cases to investigate cortical projections to the lateral hypothalamus (LHA) in ALS. Results Symptomatic SOD1(G93A) mice displayed an expansion of projections from agranular insula, ventrolateral orbitofrontal and secondary motor cortex to the LHA. These findings were reproduced in an independent cohort by using a different analytic approach. In contrast, in the FusΔNLS ALS mouse model hypothalamic inputs from insula and orbitofrontal cortex were maintained while the projections from motor cortex were lost. The DTI-MRI data confirmed the disruption of the orbitofrontal-hypothalamic tract in ALS patients. Conclusion This study provides converging murine and human data demonstrating the selective structural disruption of hypothalamic inputs in ALS as a promising factor contributing to the origin of the hypermetabolic phenotype.
EXCLUSION CRITERIA
Creators: name: Luciara Fabiane Sebold
name: Amante, Lucia Nazareth
name: Vicente, Camila
name: SILVEIRA, LORENA BARROS DA
name: Huiana Cristine Lucca
Publisher: name: OSF Registries
Year: 2024

description: Editorials.
Letters to the editor.
Annals of scientific events (abstracts).
Opinion articles.
Duplicate publications.
Studies whose population studied is not human beings.
Oligodendrogenesis is a key process for cognitive performance improvement induced by voluntary physical activity
Creators: name: Eugenin Von Bernhardi, Jaime
name: Dimou, Leda
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: GPR17
subject: NG2-glia
subject: Novel object recognition test
subject: DDC 150 / Psychology
subject: Myelination
subject: Cognition
subject: Exercise
subject: Neuroglia
subject: Running
subject: Kognition
subject: Körperliche Belastung
subject: Glia
subject: Myelogenese

description: Physical activity (PA) promotes the proliferation of neural stem cells and enhances neurogenesis in the dentate gyrus resulting in hippocampal circuit remodeling and cognitive enhancement. Nonetheless, knowledge of other neural progenitors affected by PA and the mechanisms through which they could contribute to circuit plasticity and cognitive enhancement are still poorly understood. In this work we demonstrated that NG2-glia, also known as oligodendrocyte progenitor cells, show enhanced proliferation and differentiation in response to voluntary PA in a brain region-dependent manner in adult mice. Surprisingly, preventing NG2-glia differentiation during enhanced PA abolishes the exercise-associated cognitive improvement without affecting neurogenesis or baseline learning capacity. Thus, here we provided new evidence highlighting the requirement of oligodendrogenesis for exercise induced-cognition enhancement.
Additional file 13 of Single-cell RNA sequencing of the retina in a model of retinitis pigmentosa reveals early responses to degeneration in rods and cones
Creators: name: Karademir, Duygu
name: Todorova, Vyara
name: Ebner, Lynn J. A.
name: Samardzija, Marijana
name: Grimm, Christian
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 13: Figure S5. Additional stainings for EGR1 in rd10 and wild-type retinas. Co-immunofluorescence for EGR1 (red) and GS (green) as a Müller glia marker was performed in retinas of (A) wild-type control at P21 or (B-C) rd10 mice at P21. (D) Co-immunofluorescence for (red) and OPN1SW (green) as a cone marker in a retinal section of a wild-type control mouse at P35. Arrows point to EGR1-positive Müller glia nuclei close to the outer rim of the INL. The arrowhead indicates an EGR1-positive Müller glia nucleus at its expected position. Scale bars: 50 μm. PS: Photoreceptor segments. ONL: outer nuclear layer. INL: inner nuclear layer. IPL: inner plexiform layer. GCL: ganglion cell layer.
A collection of Roman and later finds from Kirkby Thore, 1985-1988
Creators: name: Richardson, Colin
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 97, 63-78
description: Reports finds made over a period of years by metal-detector. Despite the lack of archaeological context they are thought an important addition to the Roman fort and settlement.
Recording of Hadrian's Wall at Willowford Farm.
Creators: name: Whitworth, Alan M
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 97, 57-62
description: Reports two watching/recording briefs at the site in advance of building work across the Wall ditch and the consolidation of newly exposed length of Wall.
Additional file 12 of Single-cell RNA sequencing of the retina in a model of retinitis pigmentosa reveals early responses to degeneration in rods and cones
Creators: name: Karademir, Duygu
name: Todorova, Vyara
name: Ebner, Lynn J. A.
name: Samardzija, Marijana
name: Grimm, Christian
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 12: Figure S4. Relative expression levels of selected genes in rd10 and wild-type retinas. Expression levels of selected genes were determined in retinas of rd10 (blue) and wild-type (red) mice at various ages, relative to the average of C57BL/6 P21 retinas. Shown are boxplots with individual data points. N=3 per time point per strain. *: p < 0.05, **: p < 0.01, ***: p < 0.001, ****: p < 0.0001; two-way ANOVA with Tukey’s range test.
Lake Sinai virus is a diverse, globally distributed but not emerging multi‐strain honeybee virus
Creators: name: Hou, Chunsheng
name: Liang, Hao
name: Chen, Chenxiao
name: Zhao, Hongxia
name: Zhao, Pengfei
name: Deng, Shuai
name: Li, Beibei
name: Yang, Dahe
name: Yang, Sa
name: Wilfert, Lena
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: vector
subject: virus
subject: DDC 570 / Life sciences
subject: DDC 590 / Animals (Zoology)
subject: Emerging infectious diseases
subject: Honeybee
subject: Varroa
subject: Biene
subject: Varroa destructor
subject: Viren

description: Domesticated honeybees and wild bees are some of the most important beneficial insects for human and environmental health, but infectious diseases pose a serious risk to these pollinators, particularly following the emergence of the ectoparasitic mite Varroa destructor as a viral vector. The acquisition of this novel viral vector from the Asian honeybee Apis ceranae has fundamentally changed viral epidemiology in its new host, the western honeybee A. mellifera. While the recently discovered Lake Sinai Viruses (LSV) have been associated with weak honeybee colonies, they have not been associated with vector-borne transmission. By combining a large-scale multi-year survey of LSV in Chinese A. mellifera and A. cerana honeybee colonies with globally available LSV-sequence data, we investigate the global epidemiology of this virus. We find that globally distributed LSV is a highly diverse multi-strain virus, which is predominantly associated with the western honeybee A. mellifera. In contrast to the vector-borne deformed wing virus, LSV is not an emerging disease. Instead, demographic reconstruction and strong global and local population structure indicates that it is a highly variable multi-strain virus in a stable association with its main host, the western honeybee. Prevalence patterns in China suggest a potential role for migratory beekeeping in the spread of this pathogen, demonstrating the potential for disease transmission with the man-made transport of beneficial insects.
A Prehistoric ritual sequence at Oddendale, near Shap.
Creators: name: Turnbull, Percival
name: Walsh, Deborah
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 97, 11-44
description: Reports work on a small annular earthwork apparently the focus for ritual and burial throughout the Neo and EBA and constructed in four main phases. Two third millennium BC concentric timber-post-circles were demolished and the tops of the post pits sealed by substantial settings of boulders. This in turn was succeeded by a simple ring-cairn in the EBA, to which was later added a rectangular platform of boulders with a feature like a facade on one side of the ring-cairn. A long sequence of ceremonial activity is indicated, to which considerable funerary activity may be regarded as secondary in importance. There are notes on `Identification of charcoal samples' by Jennifer Jones (23), `Pollen analysis' by Samantha Chinn (23--5), `The lithic material' by Robert Young (26--9), and `The human remains' by Mandy Marlow (32--9).
The Prehistoric Occupation of Blenkett Wood near Allithwaite.
Creators: name: Salisbury, C R
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 97, 1-10
description: Details Pal and prehist evidence and controversy surrounding Kirkhead Cave, also Whitton's Cave, Kents Bank Cavern, and Site 17 (a collapsed cave). Concludes that the Wood evinces Late Pleistocene occupation in south Cumbria.
Weighted average ensemble-based semantic segmentation in biological electron microscopy images
Creators: name: Devan, Kavitha Shaga
name: Kestler, Hans A.
name: Read, Clarissa
name: Walther, Paul
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Automated image analysis
subject: Semantic segmentation
subject: Ensemble-based machine learning
subject: DDC 150 / Psychology
subject: DDC 570 / Life sciences
subject: Artificial intelligence
subject: Electron microscopy
subject: Ensemble learning (Machine learning)
subject: Deep learning
subject: Künstliche Intelligenz
subject: Elektronenmikroskopie
subject: Maschinelles Lernen

description: Semantic segmentation of electron microscopy images using deep learning methods is a valuable tool for the detailed analysis of organelles and cell structures. However, these methods require a large amount of labeled ground truth data that is often unavailable. To address this limitation, we present a weighted average ensemble model that can automatically segment biological structures in electron microscopy images when trained with only a small dataset. Thus, we exploit the fact that a combination of diverse base-learners is able to outperform one single segmentation model. Our experiments with seven different biological electron microscopy datasets demonstrate quantitative and qualitative improvements. We show that the Grad-CAM method can be used to interpret and verify the prediction of our model. Compared with a standard U-Net, the performance of our method is superior for all tested datasets. Furthermore, our model leverages a limited number of labeled training data to segment the electron microscopy images and therefore has a high potential for automated biological applications.
Sustained response with ixekizumab treatment of moderate-to-severe psoriasis with scalp involvement: results from three phase 3 trials (UNCOVER-1, UNCOVER-2, UNCOVER-3)
Creators: name: Reich, Kristian
name: Leonardi, Craig
name: Lebwohl, Mark
name: Kerdel, Francisco
name: Okubo, Yukari
name: Romiti, Ricardo
name: Goldblum, Orin
name: Dennehy, Ellen B.
name: Kerr, Lisa
name: Sofen, Howard
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Pharmacology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Background: Scalp is a frequently affected and difficult-to-treat area in psoriasis patients. Objective: We assessed the efficacy of ixekizumab in the treatment of patients with scalp psoriasis over 60 weeks using the Psoriasis Scalp Severity Index (PSSI). Methods: In three Phase 3, multicenter, double-blind, placebo-controlled trials, patients with moderate-to-severe psoriasis in UNCOVER-1 (N = 1296), UNCOVER-2 (N = 1224) and UNCOVER-3 (N = 1346) were randomized to subcutaneous 80 mg ixekizumab every two weeks (Q2W) or every four weeks (Q4W) after a 160 mg starting dose, or placebo through Week 12. Additional UNCOVER-2 and UNCOVER-3 cohorts were randomized to 50 mg bi-weekly etanercept through Week 12. Patients entering the open-label long-term extension (LTE) (UNCOVER-3) received ixekizumab Q4W; UNCOVER-1 and UNCOVER-2 included a blinded maintenance period in which static physician global assessment (sPGA) 0/1 responders were re-randomized to placebo, ixekizumab Q4W, or 80 mg ixekizumab every 12 weeks (Q12W) through Week 60. Results: In patients with moderate-to-severe psoriasis with baseline scalp involvement, PSSI 90 and 100 were achieved at Week 12 in higher percentages of patients treated with ixekizumab Q2W (81.7% and 74.6%) or ixekizumab Q4W (75.6% and 68.9%) compared with patients treated with placebo (7.6% and 6.7%; p p Conclusion: Ixekizumab was efficacious in treating scalp psoriasis in patients with moderate-to-severe psoriasis, with most patients achieving complete or near-complete resolution of scalp psoriasis and maintaining this response over 60 weeks.
Additional file 14 of Single-cell RNA sequencing of the retina in a model of retinitis pigmentosa reveals early responses to degeneration in rods and cones
Creators: name: Karademir, Duygu
name: Todorova, Vyara
name: Ebner, Lynn J. A.
name: Samardzija, Marijana
name: Grimm, Christian
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 14: Figure S6. Egr1 expression in the whole dataset. Two-dimensional UMAP plot of the whole dataset, with cells colored according to their normalized expression levels of Egr1. For cluster identities, see B. (B) Heatmap of average normalized expression levels of Egr1 within each cluster, split by genotype. Cluster 28 is composed only of rd10 cells. wt: wild type.
SEARCH STRATEGIES
Creators: name: Luciara Fabiane Sebold
name: Amante, Lucia Nazareth
name: SILVEIRA, LORENA BARROS DA
name: Huiana Cristine Lucca
name: Vicente, Camila
Publisher: name: OSF Registries
Year: 2024

description: With the advice of a librarian who is an expert in this type of research, prepare the search keys according to the databases.
To adapt to the databases and platforms, the Health Sciences Descriptors (DeCS) will be used for the databases in Portuguese; for LILACS, descriptors in Spanish will be used; and for databases that use the English language, Medical Subject Headings (MeSH) descriptors will be used. Along with the descriptors, the Boolean terms: AND and OR will be used to compose the search keys to be used for searches in the databases, as shown in table 1.

The record of searches in the databases with the dates, strategies and number of articles selected, with a description of the reasons why some were excluded at the time of data extraction will be attached to the review report.

Search platforms:
PubMed (National Library of Medicine)

Electronic Databases:
Medical Literature Analysis and Retrieval System on Line (MEDLINE)
Latin American Health Sciences Literature (LILACS)
Nursing Database (BDENF)
Scientific Electronic Library Online (SciELO)
SCOPUS (Elsevier)
Cumulative Index of Nursing and Allied Health Literature (CINAHL)
Web of Science (WOS)
EMBASE (Elsevier)
Educational Resources Information Center (ERIC)
Academic Google
Cochrane Library
PythonとD3.jsで作るデータベース活用を広げる可視化アプリケーション
Creators: name: Oishi, Nao
Publisher: name: figshare
Year: 2016
Subjects: subject: 80301 Bioinformatics Software
subject: FOS: Computer and information sciences
subject: 80401 Coding and Information Theory
subject: 80306 Open Software

description: slide about D3.js event