cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Association Between Midlife Obesity and Kidney Function Trajectories: The Atherosclerosis Risk in Communities (ARIC) Study
Creators: name: North, K.E.
name: Ndumele, C.E.
name: Wagenknecht, L.
name: Grams, M.E.
name: Coresh, J.
name: Giovannucci, E.L.
name: Rebholz, C.M.
name: Yu, Z.
name: Boerwinkle, E.
Publisher: name: W.B. Saunders
Year: 2021

description: Rationale & Objective: Obesity has been related to risk for chronic kidney disease. However, the associations of different measures of midlife obesity with long-term kidney function trajectories and whether they differ by sex and race are unknown. Study Design: Observational study. Setting & Participants: 13,496 participants from the Atherosclerosis Risk in Communities (ARIC) Study. Predictors: Midlife obesity status as measured by body mass index (BMI), waist-to-hip ratio, and predicted percent fat at baseline. Outcomes: Estimated glomerular filtration rate (eGFR) calculated using serum creatinine level measured at 5 study visits, and incident kidney failure with replacement therapy (KFRT). Analytical Approach: Mixed models with random intercepts and random slopes for eGFR. Cox proportional hazards models for KFRT. Results: Baseline mean age was 54 years, median eGFR was 103 mL/min/1.73 m2, and median BMI was 27 kg/m2. Over 30 years of follow-up, midlife obesity measures were associated with eGFR decline in White and Black women but not consistently in men. Adjusted for age, center, smoking, and coronary heart disease, the differences in eGFR slope per 1-SD higher BMI, waist-to-hip ratio, and predicted percent fat were 0.09 (95% CI, −0.18 to 0.36), −0.25 (95% CI, −0.50 to 0.01), and −0.14 (95% CI, −0.41 to 0.13) mL/min/1.73 m2 per decade for White men; −0.91 (95% CI, −1.15 to −0.67), −0.82 (95% CI, −1.06 to −0.58), and −1.02 (95% CI, −1.26 to −0.78) mL/min/1.73 m2 per decade for White women; −0.70 (95% CI, −1.54 to 0.14), −1.60 (95% CI, −2.42 to −0.78), and −1.24 (95% CI, −2.08 to −0.40) mL/min/1.73 m2 per decade for Black men; and −1.24 (95% CI, −2.08 to −0.40), −1.50 (95% CI, −2.05 to −0.95), and −1.43 (95% CI, −2.00 to −0.86) mL/min/1.73 m2 per decade for Black women. Obesity indicators were independently associated with risk for KFRT for all sex-race groups except White men. Limitations: Loss to follow-up during 3 decades of follow-up with 5 eGFR assessments. Conclusions: Obesity status is a risk factor for future decline in kidney function and development of KFRT in Black and White women, with less consistent associations among men.
Taeniasis case report in our media
Creators: name: Gutiérrez-Fernández, José
name: Gomez, Jairo Lopez
name: Villena, Jaime Jiménez
Publisher: name: figshare
Year: 2015
Subjects: subject: Pathology
subject: Medicine
subject: Parasitology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Diseases
subject: Ecology
subject: FOS: Biological sciences

description: Se describe un caso clínico de teniasis de gran interés por la improbabilidad de encontrarlo en nuestro medio. A case of great interest teniasis unlikely to find in our environment is described.
The EMM (Ethnic and Migrant Minorities) Survey Registry
Creators: name: Morales, Laura
name: Saji, Ami
name: Méndez, Mónica
name: Bergh, Johannes
name: Bernat, Anikó
Publisher: name: Zenodo
Year: 2021
Subjects: survey research
ethnic minorities
migrant minorities
integration
FAIR principles
metadata
Europe

description: The EMM Survey Registry is a database of quantitative surveys that have been undertaken with EMM (sub)samples across Europe and beyond since January 2000. Survey-level metadata is available for each of the surveys included in the EMM Survey Registry. The EMM Survey Registry is one of the main outputs generated by COST Action 16111 Ethmigsurveydata jointly with the Sciences Po team of the SSHOC (Social Sciences and Humanities Open Cloud) project. It is also a result of the collective efforts by the national delegations of the participating countries in the COST Action who have contributed to an initial comprehensive compilation of all the surveys targeting EMM respondents since January 2000 and until 2020 in their respective country. The EMM Survey Registry work has been coordinated by Laura Morales, Mónica Méndez, Anikó Bernat and Johannes Bergh as the leaders of Work Groups (WG) 1 and 2 of the COST Action, and by Ami Saji at Sciences Po as the researcher in the SSHOC project. Nevertheless, numerous researchers in the COST Action and the SSHOC project have contributed at various stages of the process, providing feedback on various iterations of the methodological guidelines and data collection templates as well as offering advice on the technical aspects of implementation, and participating in the quality control process. Unfortunately, they are too numerous to be listed here, but we wish to publicly acknowledge their contributions. The technical design and implementation of the registry was undertaken by Youngminds. The EMM Survey Registry is currently in version 1.0. This means that it is fully functional and displays all the metadata compiled and contributed by the national delegations of Ethmigsurveydata.
description: Access to the dataset here: https://registry.ethmigsurveydatahub.eu/
Description with a case of taeniasis in our media
Creators: name: Gutiérrez-Fernández, José
name: Gomez, Jairo Lopez
name: Villena, Jaime Jiménez
Publisher: name: figshare
Year: 2014
Subjects: subject: Pathology
subject: Medicine
subject: Parasitology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Diseases
subject: Ecology
subject: FOS: Biological sciences

description: Se describe un caso clínico de teniasis de gran interés por la improbabilidad de encontrarlo en nuestro medio. A case of great interest teniasis unlikely to find in our environment is described.
Tracing the Distribution of European Lactase Persistence Genotypes Along the Americas
Creators: name: Weiss, S.
name: Borges, V.
name: Guimarães Alves, A.C.
name: Arboleda-Bustos, C.E.
name: Tarazona-Santos, E.
name: Rainha de Souza, I.
name: Santolalla, M.
name: Santos-Lobato, B.L.
name: O’Connor, T.D.
name: Sanchez, C.
name: Lehtonen Rodrigues Souza, R.
name: Guio, H.
name: Sukow, N.M.
name: Lima-Costa, M.F.
name: Barreto, M.L.
name: Tumas, V.
name: Lescano, A.
name: Borda, V.
name: Petzl-Erler, M.L.
name: Cáceres, O.
name: Machado, M.
name: Beltrame, M.H.
name: Adelman Cipolla, G.
name: Chana-Cuevas, P.
name: Schumacher-Schuh, A.
name: Moon, J.-Y.
name: Dean, M.
name: North, K.E.
name: Arboleda, G.
name: Ferraz, H.B.
name: Fernandez, W.
name: Kaplan, R.
name: Rieder, C.R.
name: Dieguez, E.
name: Mata, I.F.
name: Padilla, C.
name: Arboleda, H.
name: Raggio, V.
name: Loesch, D.
name: Leal, T.P.
name: Mendes, M.
Publisher: name: Frontiers Media S.A.
Year: 2021

description: In adulthood, the ability to digest lactose, the main sugar present in milk of mammals, is a phenotype (lactase persistence) observed in historically herder populations, mainly Northern Europeans, Eastern Africans, and Middle Eastern nomads. As the –13910∗T allele in the MCM6 gene is the most well-characterized allele responsible for the lactase persistence phenotype, the –13910C > T (rs4988235) polymorphism is commonly evaluated in lactase persistence studies. Lactase non-persistent adults may develop symptoms of lactose intolerance when consuming dairy products. In the Americas, there is no evidence of the consumption of these products until the arrival of Europeans. However, several American countries’ dietary guidelines recommend consuming dairy for adequate human nutrition and health promotion. Considering the extensive use of dairy and the complex ancestry of Pan-American admixed populations, we studied the distribution of –13910C > T lactase persistence genotypes and its flanking haplotypes of European origin in 7,428 individuals from several Pan-American admixed populations. We found that the –13910∗T allele frequency in Pan-American admixed populations is directly correlated with allele frequency of the European sources. Moreover, we did not observe any overrepresentation of European haplotypes in the –13910C > T flanking region, suggesting no selective pressure after admixture in the Americas. Finally, considering the dominant effect of the –13910∗T allele, our results indicate that Pan-American admixed populations are likely to have higher frequency of lactose intolerance, suggesting that general dietary guidelines deserve further evaluation across the continent.
Investigating transport mechanisms of exhaust-gas aftertreatment systems
Creators: name: Ferreira Motta Barbosa, Luis Felipe
name: Reddemann, Manuel Armin
name: Kneer, Reinhold
Publisher: name: RWTH Aachen University
Year: 2022

description: 8th International Conference "Fuel Science – From Production to Propulsion", online, 23 Jun 2020 - 25 Jun 2020
Radical scavenging activities of flavonoids from roots of Akschindlium godefroyanum
Creators: name: Kanokkarn Saejueng
name: Natcha Panthama
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Engineering
subject: Biochemistry

description: Chemical constituents of crude ethyl acetate extract of roots of Akschindlium godefroyanum (Kuntze) H. Ohashi were investigated and seven flavonoids were isolated. Their structures were identified based on spectroscopic methods as well as by comparison with spectral data reported in the literature as six flavanonols and a flavonol including 7,4′-dihydroxy-5,3′-dimethoxyflavanonol (1), neophellamuretin (2), taxifolin (3), erycibenin D (4), geraldol (5), fustin (6) and garbanzol (7). Compounds 2, 4 and 7 were found in the genus Akschindlium for the first time. Compounds 3, 5 and 6 appeared to have free radical scavenging activities using DPPH assay with IC50 of 21, 40 and 15 μg/mL, respectively.
Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program
Creators: name: Tracy, R.P.
name: Lin, X.
name: Mukherjee, S.
name: Rotter, J.M.
name: Boerwinkle, E.A.
name: Guo, X.
name: Wang, H.
name: Chen, H.
name: Wilson, J.G.
name: Evans, D.S.
name: Redline, S.
name: Gottlieb, D.J.
name: Kaplan, R.C.
name: NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
name: Saxena, R.
name: Abecasis, G.R.
name: Patel, S.R.
name: Zhang, M.
name: Hillman, D.R.
name: Gharib, S.A.
name: Vasan, R.S.
name: Lane, J.M.
name: Nickerson, D.A.
name: Rich, S.S.
name: Purcell, S.M.
name: Cade, B.E.
name: Tranah, G.J.
name: Liang, J.
name: Zhu, X.
name: Shah, N.A.
name: TOPMed Sleep Working Group
name: Correa, A.
name: Cupples, L.A.
name: Sofer, T.
name: Mei, H.
name: Psaty, B.M.
name: Hanis, C.L.
name: Palmer, L.J.
name: North, K.E.
name: Stone, K.L.
name: Lee, J.
Publisher: name: BioMed Central Ltd
Year: 2021

description: Background: Sleep-disordered breathing is a common disorder associated with significant morbidity. The genetic architecture of sleep-disordered breathing remains poorly understood. Through the NHLBI Trans-Omics for Precision Medicine (TOPMed) program, we performed the first whole-genome sequence analysis of sleep-disordered breathing. Methods: The study sample was comprised of 7988 individuals of diverse ancestry. Common-variant and pathway analyses included an additional 13,257 individuals. We examined five complementary traits describing different aspects of sleep-disordered breathing: the apnea-hypopnea index, average oxyhemoglobin desaturation per event, average and minimum oxyhemoglobin saturation across the sleep episode, and the percentage of sleep with oxyhemoglobin saturation < 90%. We adjusted for age, sex, BMI, study, and family structure using MMSKAT and EMMAX mixed linear model approaches. Additional bioinformatics analyses were performed with MetaXcan, GIGSEA, and ReMap. Results: We identified a multi-ethnic set-based rare-variant association (p = 3.48 × 10−8) on chromosome X with ARMCX3. Additional rare-variant associations include ARMCX3-AS1, MRPS33, and C16orf90. Novel common-variant loci were identified in the NRG1 and SLC45A2 regions, and previously associated loci in the IL18RAP and ATP2B4 regions were associated with novel phenotypes. Transcription factor binding site enrichment identified associations with genes implicated with respiratory and craniofacial traits. Additional analyses identified significantly associated pathways. Conclusions: We have identified the first gene-based rare-variant associations with objectively measured sleep-disordered breathing traits. Our results increase the understanding of the genetic architecture of sleep-disordered breathing and highlight associations in genes that modulate lung development, inflammation, respiratory rhythmogenesis, and HIF1A-mediated hypoxic response.
Antiradical and antioxidant activity of flavones from Scutellariae baicalensis radix
Creators: name: Woźniak, Dorota
name: Dryś, Andrzej
name: Matkowski, Adam
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Physiology
subject: Biochemistry

description: We evaluated the antioxidant properties of four main flavones from Scutellaria baicalensis: baicalein, wogonin and their glucuronides – baicalin and wogonoside. We used three in vitro assays: free radical scavenging with 2,2′-diphenylpicrylhydrazyl radical, transition metal ions reducing power by phosphomolybdenum assay and inhibition of the hydroxyl radical-induced peroxidation of linoleic acid assay. All flavones have antioxidant capacity, which differs depending on the structure and mechanisms of activity. In all tests, only baicalein – the aglycone with three adjacent hydroxyl groups – exhibited consistent antioxidant effect. Wogonin protected linoleic acid against oxidation. Baicalin displayed less potent antioxidant properties whereas wogonoside did not have significant antioxidant activity.
МИТРИДАТ И РИМ: «КТО» БЫЛ «КЕМ» НАКАНУНЕ ПЕРВОЙ МИТРИДАТОВОЙ ВОЙНЫ?
Creators: name: Молев Евгений Александрович
Publisher: name: Материалы по археологии и истории античного и средневекового Причерноморья
Year: 2019
Subjects: Понт
Рим
Митридат VI Евпатор
агрессор
жертва
внешняя политика

description: В статье рассматривается вопрос о соотношении роли и степени агрессивности Рима и Понта накануне антиримских войн Митридата VI Евпатора. Автор кратко характеризует исследования своих предшественников и дает свою оценку данного фактора для обеих сторон, ссылаясь на свидетельства античных авторов и логику исследований своих предшественников. В заключении делается вывод об оборонительном характере предвоенной внешнеполитической деятельности царя Понта, проистекающем из понимания силы и могущества его главного противника и желания сохранить и укрепить независимость своего государства за счет соседей в соответствии с идеологией того времени.
Microbial co-occurrence complicates associations of gut microbiome with US immigration, dietary intake and obesity
Creators: name: Williams-Nguyen, J.S.
name: Usyk, M.
name: Vázquez-Baeza, Y.
name: Burk, R.D.
name: North, K.E.
name: Daviglus, M.L.
name: Qi, Q.
name: Hua, S.
name: Isasi, C.R.
name: Wang, Z.
name: Wang, T.
name: Thyagarajan, B.
name: Chen, G.-C.
name: Kaplan, R.C.
name: Knight, R.
name: Cai, J.
name: McDonald, D.
Publisher: name: BioMed Central Ltd
Year: 2021

description: Background: Obesity and related comorbidities are major health concerns among many US immigrant populations. Emerging evidence suggests a potential involvement of the gut microbiome. Here, we evaluated gut microbiome features and their associations with immigration, dietary intake, and obesity in 2640 individuals from a population-based study of US Hispanics/Latinos. Results: The fecal shotgun metagenomics data indicate that greater US exposure is associated with reduced ɑ-diversity, reduced functions of fiber degradation, and alterations in individual taxa, potentially related to a westernized diet. However, a majority of gut bacterial genera show paradoxical associations, being reduced with US exposure and increased with fiber intake, but increased with obesity. The observed paradoxical associations are not explained by host characteristics or variation in bacterial species but might be related to potential microbial co-occurrence, as seen by positive correlations among Roseburia, Prevotella, Dorea, and Coprococcus. In the conditional analysis with mutual adjustment, including all genera associated with both obesity and US exposure in the same model, the positive associations of Roseburia and Prevotella with obesity did not persist, suggesting that their positive associations with obesity might be due to their co-occurrence and correlations with obesity-related taxa, such as Dorea and Coprococcus. Conclusions: Among US Hispanics/Latinos, US exposure is associated with unfavorable gut microbiome profiles for obesity risk, potentially related to westernized diet during acculturation. Microbial co-occurrence could be an important factor to consider in future studies relating individual gut microbiome taxa to environmental factors and host health and disease.
KING PACORUS/BAKUR OF LAZI
Creators: name: Phiphia, Natia
Publisher: name: Материалы по археологии и истории античного и средневекового Причерноморья
Year: 2019
Subjects: Pacorus/Bakur
Lazi
Georgia
Colchis
Iberia
Rome

description: The personality of Pacorus/Bakur the king of Lazi has become the subject of an interesting historiographic discussion in recent years. The discovery of a pitcher in Achmarda with the inscription “Ἐγὼ Πάκουρος ὁ βασιλεὺς τοῖς μνοῖς ἒδωκα” played a key role in stimulating discussion of this issue. There is every reason to believe that king Pacorus/Bakur played an active role in the events that occurred on the territory of Georgia in the third quarter of the 3rd century CE. We take into account the information provided in the “Scriptores Historiae Augustae”, on the facts of the discovery of Greek inscriptions on the signet from Zhinvali and on silver vessels from Gagra and Maikop, and also take into account the passage from “Life of Kartli”. There is every reason to believe that Pacorus/Bakur became king of Lazi at the behest of Antoninus Pius. The Lazi managed to unite the whole Western Georgia under their rule after half of a century. Pacorus/Bakur also supposedly participated in the power struggle in Iberia. The very fact of the discovery of a pitcher that attracted our attention suggests that Pacorus/Bakur controlled the area of modern Gagra.
A new oxathiolane from Enterobacter cloacae
Creators: name: Ann-Chee Yap
name: Wuen-Yew Teoh
name: Kok-Gan Chan
name: Kae-Shin Sim
name: Yeun-Mun Choo
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Microbiology
subject: Biochemistry

description: Enterobacter cloacae is a versatile bacterial species inhabiting a wide variety of niches and is capable of metabolising a wide variety of substances as energy resources. The fermentation culture of this bacterial species has successfully yielded one new compound, Rimboxa (1) and three known compounds, i.e. indole-3-carboxaldehyde (2), indole-3-acetic acid (3) and 3,4-di-t-butylaniline (4). Rimboxa (1) is shown to possess the 1,2-oxathiolane core structure. 3,4-Di-t-butylaniline (4) is isolated for the first time from a natural resource. These compounds were isolated and characterised using extensive chromatographic and spectroscopic methods, and were subjected to cytotoxicity evaluations.
ЭТНИЧЕСКИЕ ПЕРЕМЕЩЕНИЯ В ЗАПАДНЫХ ПРОВИНЦИЯХ ПОЗДНЕЙ РИМСКОЙ ИМПЕРИИ В IV В.: К ВОПРОСУ ОБ ИСТОРИИ НЕКОТОРЫХ ВОЙСКОВЫХ ПОДРАЗДЕЛЕНИЙ
Creators: name: Мехамадиев Евгений Александрович
Publisher: name: Материалы по археологии и истории античного и средневекового Причерноморья
Year: 2019
Subjects: германцы
бритты
франки
Амвросий
Арбогаст
пограничные гарнизоны
экспедиционные армии.

description: В IV в. центральная администрация Римской империи часто привлекала на военную службу представителей различных внешних племен, живших на границе с империей, применительно к западным провинциям империи эта политика, конечно же, в первую очередь затрагивала германские племена, располагавшиеся вдоль рейнской границы. Тем не менее, автор данной статьи стремится выяснить, как римская администрация создавала не только из внешних, но и из внутренних этнических групп регулярные войсковые подразделения, т.е. подразделения, входившие в состав постоянно действующих пограничных или экспедиционных армий. Автор рассматривает особенности внутренней организационной структуры этих подразделений и правовое положение племенной аристократии этнических групп, вошедших в состав регулярных позднеримских армий. Для изучения поставленных вопросов автор обратился к агиографическим источникам («Жизнь Мартина Турского» и «Жизнь Амвросия Медиоланского»), классическим нарративным источникам (Аммиан Марцеллин и Зосим), а также к надписи из города Струмица (Республика Македония). Автор пришел к выводу, что внутренняя структура этнических боевых отрядов была такой же, как и в других регулярных подразделениях римских армий, а сами эти отряды находились под командованием своих племенных вождей, эти вожди получали почетные титулы трибуна или протектора.
Antioxidant and antifungal activity of different extracts obtained from aerial parts of Inula crithmoides L.
Creators: name: Bucchini, Anahi
name: Ricci, Donata
name: Messina, Federica
name: Marcotullio, Maria Carla
name: Curini, Massimo
name: Giamperi, Laura
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Science Policy
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Cancer
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Ecology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Molecular Biology
subject: Cell Biology
subject: Microbiology
subject: Biochemistry

description: The total phenolic content, antioxidant and antifungal activities of three Inula crithmoides extracts (n-hexane, methylene chloride and MeOH) were investigated. The methanolic extract showed the highest total phenolic content. In the DPPH assay, the methanolic and hexane extracts exhibited the highest DPPH-radical scavenging activity; in the 5-lipoxygenase assay, the hexane extract showed greater inhibitory effect with an IC50 similar to that of Trolox and ascorbic acid. The antifungal activity of the methanolic extract revealed a higher activity against Phytophtora cryptogea and Alternaria solani.
Discrimination and leukocyte telomere length by depressive symptomatology: The jackson heart study
Creators: name: Sims, M.
name: Glover, L.M.
name: North, K.E.
name: Cené, C.W.
name: Reiner, A.
name: Gebreab, S.
name: Williams, D.R.
Publisher: name: MDPI AG
Year: 2021

description: Background: Psychosocial stressors, such as perceived discrimination and depressive symptoms, may shorten telomeres and exacerbate aging-related illnesses. Methods: Participants from the Jackson Heart Study at visit 1 (2000–2004) with LTL data and Center for Epidemiological Studies-Depression (CES-D) scores (n = 580 men, n = 910 women) were utilized. The dimensions of discrimination scores (everyday, lifetime, burden of lifetime, and stress from lifetime discrimination) were standardized and categorized as low, moderate, and high. Coping responses to everyday and lifetime discrimination were categorized as passive and active coping. Multivariable linear regression analyses were performed to estimate the mean difference (standard errors-SEs) in LTL by dimensions of discrimination and coping responses stratified by CES-D scores < 16 (low) and ≥ 16 (high) and sex. Covariates were age, education, waist circumference, smoking and CVD status. Results: Neither everyday nor lifetime discrimination was associated with mean differences in LTL for men or women by levels of depressive symptoms. Burden of lifetime discrimination was marginally associated with LTL among women who reported low depressive symptoms after full adjustment (b = 0.11, SE = 0.06, p = 0.08). Passive coping with lifetime discrimination was associated with longer LTL among men who reported low depressive symptoms after full adjustment (b = 0.18, SE = 0.09, p < 0.05); and active coping with lifetime discrimination was associated with longer LTL among men who reported high depressive symptoms after full adjustment (b = 1.18, SE = 0.35, p < 0.05). Conclusions: The intersection of perceived discrimination and depressive symptomatology may be related to LTL, and the effects may vary by sex.
Protection by the flavonoids quercetin and luteolin against peroxide- or menadione-induced oxidative stress in MC3T3-E1 osteoblast cells
Creators: name: Fatokun, Amos A.
name: Tome, Mercedes
name: Smith, Robert A.
name: L. Gail Darlington
name: Stone, Trevor W.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Cancer
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Molecular Biology
subject: Cell Biology
subject: Microbiology
subject: Biochemistry

description: Potential protective effects of the flavonoids quercetin and luteolin have been examined against the oxidative stress of MC3T3-E1 osteoblast-like cells. Although hydrogen peroxide and menadione reduced cell viability, the toxicity was prevented by desferrioxamine or catalase but not superoxide dismutase, suggesting the involvement of hydrogen peroxide in both cases. Quercetin and luteolin reduced the oxidative damage, especially that caused by hydrogen peroxide. When cultures were pre-incubated with quercetin or luteolin, protection was reduced or lost. Protection was also reduced when a 24 h pre-incubation with the flavonoids was followed by exposure to menadione alone. Pretreating cultures with luteolin impaired protection by quercetin, whereas quercetin pretreatment did not affect protection by luteolin. It is concluded that quercetin and luteolin suppress oxidative damage to MC3T3-E1 cells, especially caused by peroxide. The reduction in protection by pretreatment implies a down-regulation of part of the toxic transduction pathway.
title: The Writers' Forum: Language and the Writer
title: The Writers'Forum: Language and the Writer
titleType: AlternativeTitle
Creators: name: (:Unkn) Unknown
Publisher: name: University of Massachusetts Amherst
Year: 1993

description: Introductory text explaining, "The afternoon session ofthe conference was conceivedas a public conversation in which writers from Africa, the Caribbean,and the United States would explore topics, problems, and experiences they shared as writers, using Sembene's work as a point of departure. Unlike many such round-tables, where the participants know each other and re-enact in public the discussions they have already held in private or in8rint, this forum was unrehearsed. Someofthe writers hadnever meteach other before. On the evening before the conference, the writers gathered at the home ofRhonda Cobham-Sander and Reinhard Sander to discuss the themes they would develop the next day. They were joined by Samba Gadjigo, Thomas Cassirer, and Michael Thelwell."
CESSDA SaW D4.7: Report summarising the current state of needs of new data services
Creators: name: Krejci, Jindrich
name: Čížek, Tomáš
name: Kondyli, Dimitra
name: Fragoulis, Georges
name: Oliveira, Claudia
name: Howard, John
name: Alfredsson, Iris
name: Hegedus, Peter
Publisher: name: Zenodo
Year: 2017
Subjects: Strategy and Policy

description: This report is one of the results of the CESSDA SaW (Strengthening and widening) project task 4.5 - Strengthening and widening through establishing a CESSDA partner network of established non-member data services to support processes of integration into CESSDA membership and establish a wide collaborative environment among European data service. The first goal of the task 4.5 was to discover and monitor the capacities of European data services outside the current CESSDA ERIC membership. In relation to the task 4.5 two main objectives were discussed and met at the collaborative workshops during the CESSDA SaW project. The first objective was to establish an informal collaborative network of current and potential CESSDA partners. The second objective was to collect information regarding the needs of possible future cooperation. Using the information from the non-CESSDA member data services, deliverable D4.7 summarises the current state and needs of these data services and examines them on four main levels: the technical level, the human-resources level, the legal and the political framework of the data services.
Cytotoxic, antibacterial and antioxidant activities of extracts of the bark of Melia azedarach (China Berry)
Creators: name: Zahoor, Muhammad
name: Ahmed, Manzoor
name: Sumaira Naz
name: Musarrat Ayaz
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Cancer
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Meta Science
subject: Ecology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Microbiology
subject: Biochemistry

description: Nature provides a variety of drugs and medicinal agents derived from plants. This study was conducted to determine antimicrobial, antioxidant and cytotoxic activities of extracts of Melia azedarach bark with methanol/water (9:1 v/v), chloroform, butanol, hexane, water and ethyl acetate. For the determination of the antimicrobial activities, the agar well diffusion method was employed. Cytotoxicity was studied by brine shrimp lethality assay; antioxidant activities were measured using 1,1-diphenyl-2-picrylhydrazyl. The chloroform extract was active against Enterobacter aerogenes and Proteus mirabilis, the ethyl acetate extract had highest antibacterial spectrum against Pseudomonas aeruginosa, the n-hexane extract had highest inhibition against E. aerogenes, the aqueous extract showed highest activities against P. mirabilis, the butanol fraction showed highest activities against E. aerogenes and the methanolic extract was highly active against P. mirabilis.
ТРИДЦАТЬ ТРЕТЬЯ СТРАНА ВСЕОБЩЕЙ АЗИИ ПО «ДРЕВНЕАРМЯНСКОЙ ГЕОГРАФИИ»: АРИК (АРИАНА—АРИЯ) ИЛИ ПАРФИЯ
Creators: name: Арутюнян Акоп Жораевич
Publisher: name: Материалы по археологии и истории античного и средневекового Причерноморья
Year: 2019
Subjects: Мовсес Хоренаци
Анания Ширакаци
«Древнеармянская география»
история Армении
История Ирана
Арик
Парфия

description: В «Древнеармянской географии» тридцать третьей страной Всеобщей Азии названа Арик, в которой есть основания видеть как Арию, так и Ариану. Описание этой страны весьма небрежное. Сказано, что Арик состоит из одиннадцати провинций. Однако названы и описаны лишь четыре из них. Складывается впечатление, что Арик — не Парфия. Действительно, вторая из этих стран также описана в «Древнеармянской географии». Причем сведения о ней довольно точные. Судим по тому, что приведены подробные сведения о ее восточных и северо-восточных пределах. Однако мы эту точку зрения принять не можем. Настаиваем на том, что Арик — Парфия. Полагаем, что М. Хоренаци не мог упомянуть ее из-за негативного отношения Сасанидов к династии Аршакидов. Сведения о Парфии были добавлены в «Древнеармянскую географию» А. Ширакаци. После него описание этой страны было по небрежности искажены неизвестным переписчиком. В любом случае, «Древнеармянская география» является ценным источником по истории и географии Парфии.
ТИБЕРИЙ ЮЛИЙ ДУПТУН — ПОСЛЕДНИЙ ЦАРЬ БОСПОРА И ПОЛИТИКА ИМПЕРАТОРА АНАСТАСИЯ
Creators: name: Болгов Николай Николаевич
name: Зайцева Ирина Валерьевна
Publisher: name: Материалы по археологии и истории античного и средневекового Причерноморья
Year: 2019
Subjects: Боспор
позднеантичное Боспорское царство
Тиберий Юлий Дуптун
эпиграфика Боспора
строительная надпись Дуптуна
Ранняя Византия
византийско-боспорские связи

description: В данной статье исследуется вопрос о датировке строительной надписи последнего известного царя античного Боспора Тиберия Юлия Дуптуна. В надписи присутствует лакуна, позволяющая предположить, что на ее месте стоял термин «индикт», что позволяет переосмыслить время ее написания — ведь датировка по индиктам начала осуществляться с VI в. Аналогично сомнительной выглядит устоявшаяся в эпиграфике отсылка надписи к октябрю и интерпретация числовых знаков. Согласно нашей гипотезе, данная строительная надпись относится к началу VI в., сделана в сентябре в начале индикта, а ее христианский и проимперский характер отражает политику императора Анастасия I по мирной интеграции в империю Боспорского государства, с которым усилились культурные связи. Это косвенно находит подтверждение в письменных источниках этого периода.
ЗНАКИ ИДЕНТИЧНОСТИ МОРЯКОВ: ПО МАТЕРИАЛАМ ПОРТОВЫХ ГОРОДОВ ГЕНУЭЗСКОЙ ГАЗАРИИ XIV—XV В.
Creators: name: Еманов Александр Георгиевич
Publisher: name: Материалы по археологии и истории античного и средневекового Причерноморья
Year: 2019
Subjects: Генуэзская Газария
Крым
Кафа
XIV—XV вв.
моряки
шиурма
навы
галеры
дромоны
панфилы
барки
флаги
вымпелы
гюйсы
гербы
граффити

description: На основе широкого круга источников, публично-правовых документов, нотариальных актов, нарративных текстов, морских карт, портоланов, геральдики, сфрагистики и эпиграфики рассмотрена система символической коммуникации в социальной среде моряков Кафы и Генуэзской Газарии позднего средневековья, выявлены элементы политической, портовой, флотской, корабельной и индивидуальной идентификации, рассмотрены флаги, вымпелы и гюйсы кораблей, гербы капитанов, печати навигаторов—предпринимателей, личные знаки «людей моря». Определена группа «морских граффити» на объектах культовой архитектуры в портовых городах Генуэзской Газарии XIV—XVвв., выделены пять основных типов «морских граффити»: 1. Nave, 2. Vela navis, 3. Rosa ventorum, 4. Stella maris, 5. Baculus Jacobi. Предложено прочтение пяти личных монограмм моряков из местной грекопонтийской и крымской среды. Аргументировано суждение о смысле и назначении монументализированных личных знаков моряков в сакральной коммуникации.
ТРОЯНСКАЯ ВОЙНА АССИРИЙЦЕВ: РЕДКОЕ ОБОЗНАЧЕНИЕ ТУРЕЦКО-ТАТАРСКИХ ВОЙСК В ПОХВАЛЕ ЯНУ III СОБЕСКОМУ
Creators: name: Богатырев Арсений Владимирович
Publisher: name: Материалы по археологии и истории античного и средневекового Причерноморья
Year: 2019
Subjects: народ в литературном зеркале
турки
татары
поляки
Речь Посполитая
1674 г.
апология Яна III Собеского и его предков
В.М. Тяпкин

description: Восславляя военные подвиги новоизбранного польского короля Яна III Собеского, авторы адресованного ему «слова», переведенного на русский язык, связали побежденные поляками отряды «неверных» турок и крымских татар с выходцами с территорий Ассирии и Фригии, разгромленных древними греками. Выявляются истоки такого уподобления, приводятся параллели в карьере нового польского монарха, примеры из польской и русской литератур, говорящие о необычности для творчества писателей XVII столетия обозначения мусульман-завоевателей ассирийцами и фригийцами.
ИНСТИТУАЛИЗАЦИЯ ЮРИДИЧЕСКОГО ОФОРМЛЕНИЯ СОСЛОВНОЙ ПРИНАДЛЕЖНОСТИ КАРАИМОВ К КУПЕЧЕСТВУ И МЕЩАНСТВУ В КОНЦЕ XVIII — ПЕРВОЙ ПОЛОВИНЕ XIX В
Creators: name: Прохоров Дмитрий Анатольевич
Publisher: name: Материалы по археологии и истории античного и средневекового Причерноморья
Year: 2019
Subjects: Российская империя
Крым
караимы
сословия
купечество
мещанство

description: В статье рассмотрены основные аспекты изменения социально-экономического статуса караимов после присоединения Крыма к России в конце XVIII — первой половине XIX в. Проанализированы законодательные акты и постановления российского правительства, принятые в отношении правового и экономического положения караимского населения. Выявлены архивные документы, в которых отражены этапы институализации юридического оформления принадлежности караимов к таким социальным категориям населения, как купечество и мещанство. Сделан вывод о том, что в правовом поле Российской империи караимы не только получили новый юридический статус, по которому им предоставлялись различные права и привилегии, но и смогли динамично интегрироваться в социальную и фискальную системы Российской империи.
РОССИЙСКАЯ АКАДЕМИЯ НАУК И СУДЬБА КУЛЬТУРНО-ИСТОРИЧЕСКОГО НАСЛЕДИЯ КРЫМА В 1917—1918 ГГ. (КОЛЛЕКЦИИ А.Л. БЕРТЬЕ-ДЕЛАГАРДА)
Creators: name: Бухарин Михаил Дмитриевич
Publisher: name: Материалы по археологии и истории античного и средневекового Причерноморья
Year: 2019
Subjects: историко-культурные коллекции
Крым
музеи
архивы
Российская академия наук
А.Л. Бертье-Делагард
С.Ф. Ольденбург

description: В период после октябрьского переворота 1917 г. остро встал вопрос о сохранении историкокультурного наследия России. В послереволюционное лихолетье многие частные музейные собрания находились под угрозой уничтожения: продажи, переплавки. Грабежи, массовый вандализм приводили к многочисленным невозвратным пропажам. Члены Российской академии наук отдавали себе отчет в происходящем и некоторые из них максимально остро ставили перед государством вопрос о необходимости принять срочные меры для сохранения российской материальной культуры. Академики С.Ф. Ольденбург, Н.Я. Марр, В.В. Бартольд, целый ряд других выдающихся ученых (П.К. Козлов), сотрудников музеев активно участвовали в культуро-охранной деятельности. Одним из выдающихся исследователей и собирателей античных древностей был А.Л. Бертье-Делагарда (1842— 1920), живший и работавший в Крыму и оказавшийся из-за преклонного возраста, состояния здоровья и отсутствия дохода в крайне тяжелом положении. В начале 1918 г. Таврическая ученая архивная комиссия обратилась в Российскую академию наук с просьбой спасти уникальное историческое собрание А.Л. Бертье-Делагард и помочь материально ученому. Непременный секретарь РАН академик С.Ф. Ольденбург, используя личные связи и следуя курсу на поиск компромиссов с новой властью, обратился к наркому просвещения А.В. Луначарскому с просьбой помочь решить этот вопрос, однако перипетии политической истории Крыма 1918—1919 годов помешали его решению и ценнейшее собрание было продано по частям. В настоящий момент часть собрания Бертье-Делагарда хранится в Британском музее.
БРОНЗОВЫЕ МОНЕТЫ САВРОМАТА I С РАЗВЕРНУТЫМ ВЛЕВО БЮСТОМ ПРАВИТЕЛЯ НА АВЕРСЕ КАК ИСТОЧНИК ИСТОРИЧЕСКОЙ ИНФОРМАЦИИ
Creators: name: Чореф Михаил Михайлович
Publisher: name: Материалы по археологии и истории античного и средневекового Причерноморья
Year: 2019
Subjects: археология
история
нумизматика
Боспорское царство
Савромат I.

description: Объектами исследования стали бронзовые монеты Савромата I (93—123/124) с развернутым влево бюстом государя на аверсе и с изображениями Афродиты Апатуры, Ники, а также горящей крепости и аллегории побежденной страны — фигуры стоящей на коленях связанной женщины на реверсе. Их чеканили не только с финансовыми, но и с пропагандистскими целями. Не случайно изображения Афродиты Апатуры и Ники на них обрамлены лавровым венком. С той же целью на монетах поместили изображение горящей крепости и аллегорию побежденной страны. Жителей Боспора информировали о благочестии государя, а также славили его победы, одержанные в войне со скифами. Савромату I удалось захватить важную крепость варваров, находившуюся на периферии Боспорского царства. Бюст правителя был развернут на изучаемых монетах влево для привлечения внимания населения к этим платежным средствам
«ΚΑΘΡΕΠΤΗΣ ΓΥΝΑΙΚΩΝ» КОНСТАНТИНА ДАПОНТЕ — ПУТЕШЕСТВИЕ В КРЫМ В ПОЛИТИЧЕСКИХ СТИХАХ (1746)
Creators: name: Штефан Альбрехт
Publisher: name: Материалы по археологии и истории античного и средневекового Причерноморья
Year: 2019
Subjects: Константин Дапонте
Крым
Селим Гирай II
греки

description: Фанариот Константин (Кесарий) Дапонте бежал в 1746 г. в Крым, где он по рекомендации Константина Маврокордатоса, господаря Валахии, был благосклонно принят ханом Селимом II Гираем. О своем пребывании он написал поэму в диалогах, в т.н. политических стихах, которую он вложил в свое огромное «Καθρέπτης γυναικών», то есть в «Зерцало жен». Дапонте — первый (ранний) современный греческий писатель, который сделал Крым доступным для греков своего времени. Он также поднял осознание того, что это место, хотя и татарское, но и действительно греческое место, — хотя и без ссылки на греческую древность и византийские времена. Поскольку работа была очень распространена, его описание Крыма весьма интересно. Дапонте не пишет ничего замечательного о политической ситуации в Крыму, хотя и предоставил своим соотечественникам полезные сведения. Интересны замечания Дапонтеса о грубой красоте монастыря, которая контрастирует с аркадными прибрежными лугами, а также о греческом населении, живущем близ Бахчисарая.
When norms and rules collide: the social production of institutional conflict in the European Union
Creators: name: Norman, Ludvig
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Developmental Biology
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Genetics
subject: FOS: Biological sciences
subject: Cell Biology

description: ABSTRACTThis paper addresses the question of when and why institutional conflicts break out over decision-making competencies in the European Union. It argues there is untapped potential in constructivist approaches to explain the occurrence of such conflicts. Rationalist institutionalist (RI) models based on the idea of the Commission as a ‘competence maximizer’, while serving as shorthand for understanding institutional dynamics, risk producing simplistic accounts of institutional conflicts. Tensions between broad collective understandings of policy issues and formal institutional rules can help explain why the Commission initiates institutional conflict in specific instances. This general argument is formulated as a social mechanism termed the rupture mechanism, its potential demonstrated by evidence from an in-depth process tracing study of one of the most controversial institutional conflicts between the Council and the Commission in the 2000s.
АМФОРНЫЕ КЛЕЙМА ИЗ ЗОЛЬНИКА № 2 СВЯТИЛИЩА ВИКТОРОВКА І В НИЖНЕМ ПОБУЖЬЕ
Creators: name: Бондаренко Денис Владимирович
name: Иващенко Михаил Вениаминович
Publisher: name: Материалы по археологии и истории античного и средневекового Причерноморья
Year: 2019
Subjects: Нижнее Побужье
Викторовка I
археологические раскопки
зольник
амфорные клейма
хронология
IV—III вв. до н.э.

description: В работе публикуются и анализируются амфорные клейма из раннеэллинистического зольника № 2 античного святилища Викторовка I по материалам раскопок 2017 и 2019 гг. Всего было выявлено девять оттисков, позволяющих констатировать попадание клеймёной амфорной тары в засыпь зольника в течении около шестидесяти лет — с 20-х гг. IV по начало 60-х гг. III вв. до н.э. Самые ранние клейма в комплексе — синопские, а самое позднее — родосское. Присутствие в зольнике «колесовидного» аканфского клейма, а также оттиска неустановленного центра Ἑρμι(-), даёт возможность скорректировать их хронологию и датировать не ранее последней трети IV в. до н.э.
Factores de riesgo para peso bajo y muy bajo al nacimiento. Hospital Gineco Obstétrico Isidro Ayora (HGOIA), Quito.
Creators: name: Vasco-Morales, Santiago
name: Arturo-Delgado, Linda
name: Toapanta-Pinta, Paola
Publisher: name: Zenodo
Year: 2020
Subjects: Recién Nacido de muy Bajo Peso

description: Los neonatos de Muy Bajo Peso al Nacer (MBPN), constituyen un bajo porcentaje de los nacimientos, pero determinan un importante aporte a la morbilidad y mortalidad neonatal e infantil. Se realizó un estudio observacional retrospectivo, analítico caso control, de la base de datos del Sistema Informático Perinatal (SIP) del hospital Gineco Obstétrico Isidro Ayora de los últimos 8 años, los datos se analizaron mediante modelos de regresión logística simple y múltiple, se presenta el OR y su intervalo de confianza 95%, los datos se procesaron con el programa R 3.3.1 (2016). Las variables asociadas a MBPN fueron: nacimiento vía cesárea, número de consultas prenatales, edad gestacional, edad materna, hemorragias en la gestante, trastornos hipertensivos en el embarazo, madre con nefropatía, sexo masculino, ruptura prematura de membranas mayor a 18 horas. La mayoría de los factores que se reportan asociación con MBPN en las diferentes publicaciones, se encontró en este estudio.
New macrocyclic diterpenes from Euphorbia connata Boiss. with cytotoxic activities on human breast cancer cell lines
Creators: name: Somayeh Shadi
name: Hojjatollah Saeidi
name: Ghanadian, Mustafa
name: Rahimnejad, Mohammad Reza
name: Aghaei, Mahmoud
name: Ayatollahi, Syed Majid
name: M. Iqbal Choudhary
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Cancer
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Pharmacology
subject: Physics
subject: Engineering
subject: Biochemistry
subject: Biophysics

description: Acetone:chloroform (1:2) extract of the aerial parts of Euphorbia connata Boiss. (Euphorbiaceae) was investigated for its diterpenoids. This led to the isolation of one known and two new diterpenes, belonging to the pentahydroxy-13(17)-epoxy-8,10(18)-myrsinadiene and tetrahydroxy-5,6-epoxy-14-oxo-jatropha-11(E)-ene classes. The structures were elucidated based on 13C and 1H NMR as well as 2D NMR, IR and MS spectra and the cytotoxicity for compounds 1–3 were evaluated by using MTT assay against two human breast cancer cell lines. Myrsinane-type compounds – 3,7,14,15-tetraacetyl-5-propanoyl-13(17)-epoxy-8,10(18)-myrsinadiene (1) and 3,7,10,14,15-pentaacetyl-5-butanoyl-13,17-epoxy-8-myrsinene (2) – exhibited moderate inhibitory effects, with IC50 values of 24.53 ± 3.39 and 26.67 ± 1.41 μM against the MDA-MB cell line, and 37.73 ± 3.41 and 34.57 ± 2.12 μM against the MCF-7 cell line, respectively. Jatrophane-type diterpene – 5,6-epoxy-8,9,15-triacetyl-3-benzoyl-14-oxo-jatropha-11(E)-ene (3) – showed weak cytotoxicity, with IC50 values of 55.67 ± 7.09 μM against MDA-MB, and moderate cytotoxicity with IC50 values of 24.33 ± 3.21 μM against MCF-7 cell line.
РЕЦЕНЗИЯ НА КН.: АРУТЮНЯН А.Ж. 2019. СТОЛИЦА ВЕЛИКОЙ АРМЕНИИ ТИГРАНАКЕРТ В КОНТЕКСТЕ АРМЯНО-РИМСКО-БЛИЖНЕВОСТОЧНЫХ МЕЖГОСУДАРСТВЕННЫХ ОТНОШЕНИЙ (296—301 ГГ.). РОСТОВ-НА-ДОНУ; ТАГАНРОГ: ЮФУ
Creators: name: Болгов Николай Николаевич
Publisher: name: Материалы по археологии и истории античного и средневекового Причерноморья
Year: 2019
Subjects: рецензия
Древняя Армения
международные отношения
Тигранакерт
Ближний Восток
Рим
Иран

description: В рецензии анализируется новая монография ведущего антиковеда Республики Армения А.Ж. Арутюняна, прочно интегрированного в антиковедческое сообщество России. Она продолжает многолетние исследования автора в области исторической географии и межгосударственных отношений в древности в контексте истории Армении. В центре внимания книги находится ключевой момент древнеармянской истории — рубеж III—IV вв. А.Ж. Арутюнян связывает изменение геополитической ситуации на Ближнем Востоке с принятием христианства в Армении. Данный вывод является новым, важным и всесторонне обоснованным.