cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Automatic treatment planning facilitates fast generation of high-quality treatment plans for esophageal cancer
Creators: name: Hansen, Christian Rønn
name: Nielsen, Morten
name: Bertelsen, Anders Smedegaard
name: Hazell, Irene
name: Holtved, Eva
name: Zukauskaite, Ruta
name: Bjerregaard, Jon Kroll
name: Brink, Carsten
name: Bernchou, Uffe
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Background: The quality of radiotherapy planning has improved substantially in the last decade with the introduction of intensity modulated radiotherapy. The purpose of this study was to analyze the plan quality and efficacy of automatically (AU) generated VMAT plans for inoperable esophageal cancer patients. Material and Methods: Thirty-two consecutive inoperable patients with esophageal cancer originally treated with manually (MA) generated volumetric modulated arc therapy (VMAT) plans were retrospectively replanned using an auto-planning engine. All plans were optimized with one full 6MV VMAT arc giving 60 Gy to the primary target and 50 Gy to the elective target. The planning techniques were blinded before clinical evaluation by three specialized oncologists. To supplement the clinical evaluation, the optimization time for the AU plan was recorded along with DVH parameters for all plans. Results: Upon clinical evaluation, the AU plan was preferred for 31/32 patients, and for one patient, there was no difference in the plans. In terms of DVH parameters, similar target coverage was obtained between the two planning methods. The mean dose for the spinal cord increased by 1.8 Gy using AU (p = .002), whereas the mean lung dose decreased by 1.9 Gy (p p = .001). The median optimization time for AU plans was 117 min. Conclusions: The AU plans were in general preferred and showed a lower mean dose to the lungs. The automation of the planning process generated esophageal cancer treatment plans quickly and with high quality.
The potential of hyperpolarized 13C magnetic resonance spectroscopy to monitor the effect of combretastatin based vascular disrupting agents
Creators: name: Iversen, Ane B.
name: Busk, Morten
name: Bertelsen, Lotte B.
name: Laustsen, Christoffer
name: Munk, Ole L.
name: Nielsen, Thomas
name: Wittenborn, Thomas R.
name: Bussink, Johan
name: Lok, Jasper
name: Stødkilde-Jørgensen, Hans
name: Horsman, Michael R.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: Background: Targeting tumor vasculature with vascular disrupting agents (VDAs) results in substantial cell death that precede tumor shrinkage. Here, we investigate the potential of hyperpolarized magnetic resonance spectroscopy (HPMRS) to monitor early metabolic changes associated with VDA treatment. Methods: Mice bearing C3H mammary carcinomas were treated with the VDAs combretastatin-A4-phosphate (CA4P) or the analog OXi4503, and HPMRS was performed following [1-13C]pyruvate administration. Similarly, treated mice were positron emission tomography (PET) scanned following administration of the glucose analog FDG. Finally, metabolic imaging parameters were compared to tumor regrowth delay and measures of vascular damage, derived from dynamic contrast-agent enhanced magnetic resonance imaging (DCE-MRI) and histology. Results: VDA-treatment impaired tumor perfusion (histology and DCE-MRI), reduced FDG uptake, increased necrosis, and slowed tumor growth. HPMRS, revealed that the [1-13C]pyruvate-to-[1-13C]lactate conversion remained unaltered, whereas [1-13C]lactate-to-[13C]bicarbonate (originating from respiratory CO2) ratios increased significantly following treatment. Conclusions: DCE-MRI and FDG-PET revealed loss of vessel functionality, impaired glucose delivery and reduced metabolic activity prior to cell death. [1-13C]lactate-to-[13C]bicarbonate ratios increased significantly during treatment, indicating a decline in respiratory activity driven by the onset of hypoxia. HPMRS is promising for early detection of metabolic stress inflicted by VDAs, which cannot easily be inferred based on blood flow measurements.
Additional file 1 of classifieR a flexible interactive cloud-application for functional annotation of cancer transcriptomes
Creators: name: Quinn, Gerard P.
name: Sessler, Tamas
name: Ahmaderaghi, Baharak
name: Lambe, Shauna
name: VanSteenhouse, Harper
name: Lawler, Mark
name: Wappett, Mark
name: Seligmann, Bruce
name: Longley, Daniel B.
name: McDade, Simon S.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Supplementary figures. Supplementary 1. Screenshots of the classifieR application. (A) Screenshot of main page, showing where the file is selected, what technology is used and a submission button. (B) Progress bar showing progress of the app’s stratification. (C) An example of the advanced settings that can be selected when running the analysis (D) This page of the app Includes a table with all classification data, and box plots which integrate the classifiers (CRIS/CMS) with immune population and transcription factor activity. (E) This page has a detailed table and interactive heatmap (not shown), an interactive bar chart showing transcription factor activity, a histogram of activity across all samples and a correlation plot across all samples in which the transcription factor of interest can be selected. Supplementary 2. Sample number can confound transcriptional subtyping of GSE103479. (A) Schematic of experimental plan to test number of samples for robust CRIS/CMS classification (B) Sample discordance between subsets of samples against all samples ran simultaneously in GSE103479.
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Cart. 188 (11 H 73), f. 0261r
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Archives départementales de la Côte-d'Or, Cart. 188 (11 H 73), f. 0261r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Archives départementales de la Côte-d'Or, Cart. 188 (11 H 73), f. 0261r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
The potential of hyperpolarized 13C magnetic resonance spectroscopy to monitor the effect of combretastatin based vascular disrupting agents
Creators: name: Iversen, Ane B.
name: Busk, Morten
name: Bertelsen, Lotte B.
name: Laustsen, Christoffer
name: Munk, Ole L.
name: Nielsen, Thomas
name: Wittenborn, Thomas R.
name: Bussink, Johan
name: Lok, Jasper
name: Stødkilde-Jørgensen, Hans
name: Horsman, Michael R.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer

description: Background: Targeting tumor vasculature with vascular disrupting agents (VDAs) results in substantial cell death that precede tumor shrinkage. Here, we investigate the potential of hyperpolarized magnetic resonance spectroscopy (HPMRS) to monitor early metabolic changes associated with VDA treatment. Methods: Mice bearing C3H mammary carcinomas were treated with the VDAs combretastatin-A4-phosphate (CA4P) or the analog OXi4503, and HPMRS was performed following [1-13C]pyruvate administration. Similarly, treated mice were positron emission tomography (PET) scanned following administration of the glucose analog FDG. Finally, metabolic imaging parameters were compared to tumor regrowth delay and measures of vascular damage, derived from dynamic contrast-agent enhanced magnetic resonance imaging (DCE-MRI) and histology. Results: VDA-treatment impaired tumor perfusion (histology and DCE-MRI), reduced FDG uptake, increased necrosis, and slowed tumor growth. HPMRS, revealed that the [1-13C]pyruvate-to-[1-13C]lactate conversion remained unaltered, whereas [1-13C]lactate-to-[13C]bicarbonate (originating from respiratory CO2) ratios increased significantly following treatment. Conclusions: DCE-MRI and FDG-PET revealed loss of vessel functionality, impaired glucose delivery and reduced metabolic activity prior to cell death. [1-13C]lactate-to-[13C]bicarbonate ratios increased significantly during treatment, indicating a decline in respiratory activity driven by the onset of hypoxia. HPMRS is promising for early detection of metabolic stress inflicted by VDAs, which cannot easily be inferred based on blood flow measurements.
Training Networks in VET as Innovative Concepts – Reasons and Boundaries for Training Companies to Participate
Creators: name: Leemann, Regula Julia
name: Da Rin, Sandra
name: Imdorf, Christian
Publisher: name: Institute Technology and Education University of Bremen
Year: 2015
Subjects: subject: Case studies
subject: in-company training
subject: initial vocational education and training
subject: training networks
subject: quality of VET
subject: 370 - Erziehung, Schul- und Bildungswesen

description: During the past decade vocational education policy has been furthering training networks. Enterprises which are too small or too specialised to offer an apprenticeship place on their own join a network of training companies. The responsibility for recruitment, placement, and formal qualification lies with a professionalised lead organisation. During their apprenticeship, the apprentices switch their training company on a (half-)yearly rotational basis. Based on a case study of four training networks in Switzerland the aim of this paper is to understand the reasons for the slow and hesitant institutionalisation of this new organisational form of VET that has high potential for improving quality of VET, for creating additional apprenticeship places and for integration socially disadvantaged youth into post-compulsory education.
Additional file 1 of ENNGene: an Easy Neural Network model building tool for Genomics
Creators: name: Chalupová, Eliška
name: Vaculík, Ondřej
name: Poláček, Jakub
name: Jozefov, Filip
name: Majtner, Tomáš
name: Alexiou, Panagiotis
Publisher: name: figshare
Year: 2022
Subjects: subject: Statistics
subject: FOS: Mathematics
subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences

description: Additional file 1. Documentation. Complete documentation of the current version of the ENNGene application (v1.2.2) in pdf format. Each module and its functions, together with all the parameters and available options, are described in the documentation.
title: ADCO, Cartulaire de l'office de la Porte de l'abbaye de Cîteaux, Registrum possessionum porte Cistercii (début XVe siècle), Cart. 172 (11 H 69), 115 folios, f. 0230
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire de l'office de la Porte de l'abbaye de Cîteaux, Registrum possessionum porte Cistercii (début XVe siècle), Archives départementales de la Côte-d'Or, Cart. 172 (11 H 69), 115 folios, f. 0230, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire de l'office de la Porte de l'abbaye de Cîteaux, Registrum possessionum porte Cistercii (début XVe siècle), Archives départementales de la Côte-d'Or, Cart. 172 (11 H 69), 115 folios, f. 0230, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
Predicting tumor hypoxia in non-small cell lung cancer by combining CT, FDG PET and dynamic contrast-enhanced CT
Creators: name: Even, Aniek J. G.
name: Reymen, Bart
name: Fontaine, Matthew D. La
name: Das, Marco
name: Jochems, Arthur
name: Mottaghy, Felix M.
name: Belderbos, José S. A.
name: Ruysscher, Dirk De
name: Lambin, Philippe
name: Elmpt, Wouter Van
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Cancer

description: Background: Most solid tumors contain inadequately oxygenated (i.e., hypoxic) regions, which tend to be more aggressive and treatment resistant. Hypoxia PET allows visualization of hypoxia and may enable treatment adaptation. However, hypoxia PET imaging is expensive, time-consuming and not widely available. We aimed to predict hypoxia levels in non-small cell lung cancer (NSCLC) using more easily available imaging modalities: FDG-PET/CT and dynamic contrast-enhanced CT (DCE-CT). Material and methods: For 34 NSCLC patients, included in two clinical trials, hypoxia HX4-PET/CT, planning FDG-PET/CT and DCE-CT scans were acquired before radiotherapy. Scans were non-rigidly registered to the planning CT. Tumor blood flow (BF) and blood volume (BV) were calculated by kinetic analysis of DCE-CT images. Within the gross tumor volume, independent clusters, i.e., supervoxels, were created based on FDG-PET/CT. For each supervoxel, tumor-to-background ratios (TBR) were calculated (median SUV/aorta SUVmean) for HX4-PET/CT and supervoxel features (median, SD, entropy) for the other modalities. Two random forest models (cross-validated: 10 folds, five repeats) were trained to predict the hypoxia TBR; one based on CT, FDG, BF and BV, and one with only CT and FDG features. Patients were split in a training (trial NCT01024829) and independent test set (trial NCT01210378). For each patient, predicted, and observed hypoxic volumes (HV) (TBR > 1.2) were compared. Results: Fifteen patients (3291 supervoxels) were used for training and 19 patients (1502 supervoxels) for testing. The model with all features (RMSE training: 0.19 ± 0.01, test: 0.27) outperformed the model with only CT and FDG-PET features (RMSE training: 0.20 ± 0.01, test: 0.29). All tumors of the test set were correctly classified as normoxic or hypoxic (HV > 1 cm3) by the best performing model. Conclusions: We created a data-driven methodology to predict hypoxia levels and hypoxia spatial patterns using CT, FDG-PET and DCE-CT features in NSCLC. The model correctly classifies all tumors, and could therefore, aid tumor hypoxia classification and patient stratification.
Additional file 3 of ENNGene: an Easy Neural Network model building tool for Genomics
Creators: name: Chalupová, Eliška
name: Vaculík, Ondřej
name: Poláček, Jakub
name: Jozefov, Filip
name: Majtner, Tomáš
name: Alexiou, Panagiotis
Publisher: name: figshare
Year: 2022
Subjects: subject: Statistics
subject: FOS: Mathematics
subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences

description: Additional file 3. RBP24 ROC curves. ROC curves generated by ENNGene for each experiment in the RBP24 dataset. The ROC curves are based on the evaluation of the final models on the leave-out data. The AUROC values of the corresponding ROC curves were used for comparison with the other publications and their reported AUROC values.
Emotional cascade theory and non-suicidal self-injury: the importance of imagery and positive affect
Creators: name: Hasking, Penelope A.
name: Simplicio, Martina Di
name: McEvoy, Peter M.
name: Rees, Clare S.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Grounded in Emotional Cascade Theory, we explored whether rumination and multisensory imagery-based cognitions moderated the relationships between affect and both odds of non-suicidal self-injury (NSSI), and frequency of the behaviour. A sample of 393 university students completed self-report questionnaires assessing the constructs of interest. Contrary to expectations, rumination did not emerge as a significant moderator of the affect-NSSI relationship. However, the relationship between affect and frequency of NSSI was moderated by the use of imagery. Further, the relationship between negative affect and NSSI was moderated by positive affect, underscoring the need to consider both negative and positive affect in models of NSSI. Most youth who self-injured reported thinking in images while the urge to self-injure was strong, with 53% thinking in images at least half the time. Future work is needed to explore how positive and negative affect work in concert to govern NSSI, and how imagery might either exacerbate or reduce risk of NSSI.
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Cart. 188 (11 H 73), f. 0126r
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Archives départementales de la Côte-d'Or, Cart. 188 (11 H 73), f. 0126r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Archives départementales de la Côte-d'Or, Cart. 188 (11 H 73), f. 0126r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
The Power of Conflict Management on Innovative Team Behavior
Creators: name: Sutter, Daniela
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2018
Subjects: Innovation
innovatives Teamhandeln
kooperatives Konfliktmanagement
vermeidendes Konfliktmanagement
kompetitives Konfliktmanagement
Teamklima
Scrum

description: Das primäre Ziel der vorliegenden Arbeit war es, zu untersuchen, wie das kooperative, das vermeidende und das kompetitive Konfliktmanagement das innovative Teamhandeln von agilen Teams aus der ITund Softwarebereich beeinflussen. Zusätzlich wurde untersucht, welche Effekte das Teamklima auf diesen Zusammenhang nimmt. Dafür wurden insgesamt 59 agile Teams aus 20 verschiedenen Unternehmen mittels eines quantitativen Onlinefragebogens befragt. Die Ergebnisse zeigen, dass ein signifikant positiver Zusammenhang zwischen dem kooperativen Konfliktmanagement und dem innovativen Teamhandeln besteht. Das Teamklima erwies sich als wichtiger signifikanter Moderator bezüglich dieses Zusammenhangs. Weiter konnte festgestellt werden, dass das vermeidende sowie das kompetitive Konfliktmanagement einen signifikant negativen Zusammenhang mit dem innovativen Teamhandeln aufweist. Die Annahme, dass das Konfliktmanagement eine positive Power für das innovative Teamhandeln hat, konnte bestätigt werden. Aufgrund der Ergebnisse konnten Implikationen für zukünftige Forschungsarbeiten vorgestellt und mögliche Handlungsfelder für Praktiker aufgezeigt werden, und zwar dahingehend, wie das kooperative Konfliktmanagement gefördert werden kann.
The model description and parameters, and additional analyses from School and community reopening during the COVID-19 pandemic: a mathematical modelling study
Creators: name: Yuan, Pei
name: Aruffo, Elena
name: Gatov, Evgenia
name: Tan, Yi
name: Li, Qi
name: Ogden, Nick
name: Collier, Sarah
name: Nasri, Bouchra
name: Moyles, Iain
name: Zhu, Huaiping
Publisher: name: The Royal Society
Year: 2022

description: In this file we provide details of the compartmental model used, including description of household structure, transmission process and equations. We provide list of parameters and calibration. Also, additional results are reported to complete analyses in the main text.
Additional file 1 of Rare missense mutations in ABCA7 might increase Alzheimer’s disease risk by plasma membrane exclusion
Creators: name: Bossaerts, Liene
name: Hendrickx Van de Craen, Elisabeth
name: Cacace, Rita
name: Asselbergh, Bob
name: Van Broeckhoven, Christine
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Supplementary material and methods.
Supplementary document for Noble metal modified ReS2 nanocavity for surface-enhanced Raman spectroscopy (SERS) analysis - 5330881.pdf
Creators: name: Shao, MingRui
name: Zhang, C
name: Yu, Jing
name: Jiang, Shouzhen
name: Zhao, Xiaofei
name: Li, Zhaoxiang
name: Lu, Weixi
name: man, yuan
name: Li, Zhen
Publisher: name: Optica Publishing Group
Year: 2021
Subjects: Uncategorized

description: Supplement 1: Supplementary data results
Additional file 1 of JCD-DEA: a joint covariate detection tool for differential expression analysis on tumor expression profiles
Creators: name: Li, Yi
name: Liu, Yanan
name: Wu, Yiming
name: Zhao, Xudong
Publisher: name: figshare
Year: 2019
Subjects: Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
Mathematical Sciences not elsewhere classified

description: Pairwise results on simulation data with a descending order of A5 scores. (PDF 153 kb)
Lettre de Jules François Paul de Fauris de Saint-Vincent à Jean-François Séguier, 1780-07-03
Creators: name: Fauris de Saint-Vincent, Jules François Paul de
name: De Fauris De Saint-Vincent, Jules François Paul
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021
Subjects: Antiquités (général)
Bibliographie
Epigraphie
Collections

description: [transcription] A Aix ce 3 juillet 1780

Je viens de recevoir, Monsieur, le beau présent que vous avez eu la bonté de me faire en m'envoyant les variétés littéraires de M. le présidentd'Orbessan. Je connaissais déjà le nom et la réputation que ce magistrat s'était fait par ses mélanges de poésie et de littérature. c'est un homme de mérite, il ferme la chaîne des magistrats qui ont su allier l'étude des lois avec le goût des lettres. Pendant plus de deux siècles la magistrature a produit de très beaux esprits et des gens qui ont cultivé avec succès tous les genres de littérature. Cela a bien changé de face. Il y a encore quelques gens d'affaires, et bientôt il n'y aura plus rien du tout. La philosophie moderne détruit et empoisonne toutes les vertus et tous les talents. Pardonnez-moi d'avoir épanché avec vous mon humeur qui est excitée par tout ce que je vois et tout ce que j'entends.

Les inscriptions dont j'ai eu l'honneur de vous parler dans ma dernière lettre sont très différentes de celles que vous tenez de M. Grosson. Celles-là ont été réellement trouvées dans des excavations faites à Marseille et sont incontestablement antiques au lieu que le plus grand nombre de celles que j'ai acheté est certainement faux. Elles ont été envoyées d'Italie à un homme qui achetait les antiquités à la toise sans le moindre examen. A la 1re vue on juge qu'elles n'ont pas dix ans d'ancienneté. Je vous envoie une copie de celles que j'ai [fol. 167v] sous les yeux. J'ai abandonné les autres au premier venu. Je crois les deux premières antiques. La 2de où il est parlé de l'horloge est fort inutile. Je vous prie de me faire donner des nouvelles de votre santé dont je sais fort en peine et qui m'est infiniment précieuse.

J'ai l'honneur d'être avec le plus tendre et le plus respectueux attachement,

Monsieur,

Votre très humble et très obéissant serviteur.

Saint Vincens
description: [personnes citées] Anne Marie d'Aignan, baron d' Orbessan, Jean-Baptiste Grosson
description: [reférence bibliographique citée]
Grosson Jean-Baptiste Bernard, Recueil des antiquités et des monuments marseillais qui peuvent intéresser l'histoire et les arts, Marseille, Mossy, 1773.. Orbessan, Anne Marie Daignan, marquis d', Variétés littéraires, pour servir de suite aux Mélanges..., Auch, J. P. Dupont, 1778, 2 vol. in-8°.
description: Source: [lieu de Conservation] Nîmes, Bibliothèque Carré d'Art [cote]ms. 149_4, fol. 167-167v
A GOVERNANÇA CORPORATIVA E OS PROGRAMAS DE COMPLIANCE: uma análise sob a ótica da gestão pública
Creators: name: LUIZ FERNANDO DE BRITO LOIOLA AGUIAR
Publisher: name: Zenodo
Year: 2018
Subjects: Governança Corporativa Pública
Programas de Integridade
Gestão Pública
Compliance

description: A governança corporativa, os programas de integridade e a nova gestão pública cresceram significativamente no início do século XXI. As instituições privadas e públicas puderam trocar experiências, fazer novas parcerias, criar mecanismos e métodos, criar novas teorias, ensinar, aprender e desenvolver medidas que melhorem as atividades econômicas e sociais. A figura do gestor público passou por uma série de adaptações devida a realidade que a sociedade enxerga e exige das instituições públicas. Perceberam que a governança corporativa e os programas de integridade são ferramentas adequadas para a eficiência das instituições públicas. As legislações criadas recentemente foram um avanço institucional e organizacional na administração pública brasileira, embora alguns agentes políticos as utilizassem como forma de atenuar e enfraquecer esses avanços são notória que trouxe mudança nas instituições públicas. O estudo analisado neste trabalho foi um exemplo. O Banco do Nordeste, diante da pesquisa avaliada pela Controladoria Geral da União (CGU) identificou melhorias, entretanto, ainda possui dificuldades de implementação. Por exemplo, a instituição tem uma administração voltada para governança corporativa, mas não possui um programa adequado de compliance. No que se refere à qualidade e efetividade, o Banco apresenta necessidade de ferramentas de gestão e controle no combate às práticas ilícitas internas e externas. Essa acepção do Banco sob ponto de vista de integridade revela-se em boa parte das instituições públicas brasileiras e, por isso, deve haver uma maior atenção caso contrário criará ainda mais uma imagem negativa, principalmente aos gestores públicos que são um dos principais atores na administração.
Predicting tumor hypoxia in non-small cell lung cancer by combining CT, FDG PET and dynamic contrast-enhanced CT
Creators: name: Even, Aniek J. G.
name: Reymen, Bart
name: Fontaine, Matthew D. La
name: Das, Marco
name: Jochems, Arthur
name: Mottaghy, Felix M.
name: Belderbos, José S. A.
name: Ruysscher, Dirk De
name: Lambin, Philippe
name: Elmpt, Wouter Van
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Cancer

description: Background: Most solid tumors contain inadequately oxygenated (i.e., hypoxic) regions, which tend to be more aggressive and treatment resistant. Hypoxia PET allows visualization of hypoxia and may enable treatment adaptation. However, hypoxia PET imaging is expensive, time-consuming and not widely available. We aimed to predict hypoxia levels in non-small cell lung cancer (NSCLC) using more easily available imaging modalities: FDG-PET/CT and dynamic contrast-enhanced CT (DCE-CT). Material and methods: For 34 NSCLC patients, included in two clinical trials, hypoxia HX4-PET/CT, planning FDG-PET/CT and DCE-CT scans were acquired before radiotherapy. Scans were non-rigidly registered to the planning CT. Tumor blood flow (BF) and blood volume (BV) were calculated by kinetic analysis of DCE-CT images. Within the gross tumor volume, independent clusters, i.e., supervoxels, were created based on FDG-PET/CT. For each supervoxel, tumor-to-background ratios (TBR) were calculated (median SUV/aorta SUVmean) for HX4-PET/CT and supervoxel features (median, SD, entropy) for the other modalities. Two random forest models (cross-validated: 10 folds, five repeats) were trained to predict the hypoxia TBR; one based on CT, FDG, BF and BV, and one with only CT and FDG features. Patients were split in a training (trial NCT01024829) and independent test set (trial NCT01210378). For each patient, predicted, and observed hypoxic volumes (HV) (TBR > 1.2) were compared. Results: Fifteen patients (3291 supervoxels) were used for training and 19 patients (1502 supervoxels) for testing. The model with all features (RMSE training: 0.19 ± 0.01, test: 0.27) outperformed the model with only CT and FDG-PET features (RMSE training: 0.20 ± 0.01, test: 0.29). All tumors of the test set were correctly classified as normoxic or hypoxic (HV > 1 cm3) by the best performing model. Conclusions: We created a data-driven methodology to predict hypoxia levels and hypoxia spatial patterns using CT, FDG-PET and DCE-CT features in NSCLC. The model correctly classifies all tumors, and could therefore, aid tumor hypoxia classification and patient stratification.
Regulation of Ni valence state and synergistic effects of supports in the hydrodeoxygenation of lignin-derived vanillin using pseudoboehmite-supported Ni catalysts
Creators: name: Liu, Rundong
name: Li, Zhiyu
name: Zhang, Yuchun
name: Yan, Jinliang
name: Wang, Wenwen
name: Lu, Yangyang
name: Fu, Peng
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology
subject: FOS: Biological sciences

description: Preparing 2-methoxy-4-methylphenol (MMP) through the vanillin (VAN) route is a crucial step in the high-value utilization of lignin (VTM). In this study, a series of Ni/PB catalysts were synthesized using pseudoboehmite (PB) as a carrier. Changes in the valence states of Ni were induced through H2 activation, while the impacts of reaction temperature, initial pressure, and catalyst addition were investigated based on the VTM process. The results revealed that PB exhibited a distinct mesoporous structure (average pore size of 5.8 nm), with Ni loaded in small particles size (3.88 nm). Ni species on the catalyst existed in a + 2-valence state, undergoing a change after H2 activation, with an increase in Ni0 promoting enhanced activity. The Ni/PB-450 catalyst exhibited excellent activity at 250°C for 3 hours (VAN conversion and MMP selectivity > 99%), and the catalyst demonstrated good durability, maintaining 99.1% VAN conversion and 80% MMP selectivity after two cycles. Combining the characterization and experimental results, the etherification and hydrogenation of VAN were identified as the primary reaction pathways. This study aimed to provide a new avenue for the high-value utilization of lignin and its derivatives through controlled catalyst preparation.
Additional file 1 of Challenges in eating disorder diagnosis and management among family physicians and trainees: a qualitative study
Creators: name: Tse, Angel
name: Xavier, Sabatinie
name: Trollope-Kumar, Karen
name: Agarwal, Gina
name: Lokker, Cynthia
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Additional file 1. Semi-structured question guide used during the focus groups.
Evaluation der Arbeitsprozesse in der Orthopädie Sonnenhof in Hinblick auf den Nutzen von Synergien
Creators: name: Fasnacht, Michèle
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2018

description: Die vorliegende Arbeit befasst sich mit der Analyse von Arbeits- und Veränderungsprozesse in den verschiedenen Fachbereichen des Sekretariats der Orthopädie Sonnenhof. Es werden theoretische Grundlagen zur Prozessgestaltung, deren Möglichkeiten, diese zu verschlanken, sowie zu psychologischen Faktoren in Veränderungsprozessen erläutert. Mit Experteninterviews wurden die Medizinischen Sekretärinnen zu den typischen Arbeitsprozessen, der Team- und Organisationsstruktur sowie zu möglichem Veränderungspotenzial befragt. Die Ergebnisse zeigen, dass die Aufgaben und Prozessabläufe über die Teams hinweg insgesamt sehr ähnlich ablaufen und sich allfällige Unterschiede durch Einzelheiten herauskristallisieren. Weiter zeigt sich, dass eine Vereinheitlichung in einzelnen Prozessschritten gewünscht wird, jedoch nur bedingt was die Teamstruktur anbelangt. Gründe hierfür sind der Verlust der persönlichen Beziehungen zu den Patientinnen und Patienten, die nach Vorlieben verteilten Aufgaben und die geschätzte Zusammenarbeit mit den ärztlichen Fachpersonen sowie den Teamkolleginnen. Gleichwohl können durch das Nutzen von Synergien effizientere und effektivere Arbeitsprozessen entstehen.
Topische Geschichte der Universitaet Ingolstadt in Grundrissen, perspektivischen Aufnahmen der Gebaeude, welche der Universitaet selbst gehoerten, oder in naeherer oder fernerer Beziehung zu ihr standen, darstellend …; [1855]
Creators: name: (:Unav)
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2009

description: Kurzaufnahme einer Handschrift = 0001/Cim. 17(1 (= 2 Cod.ms. 739(1)
De Boer et al. DNA metabarcoding of orchid-derived products reveals widespread illegal orchid trade. Proceedings of the Royal Society B. DOI: 10.1098/rspb.2017-1182. Electronic Supplementary Material (ESM) Table S4
Creators: name: Boer, Hugo J. De
name: Abdolbaset Ghorbani
name: Manzanilla, Vincent
name: Ancuta-Cristina Raclariu
name: Kreziou, Anna
name: Sarawut Ounjai
name: Maslin Osathanunkul
name: Gravendeel, Barbara
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 60301 Animal Systematics and Taxonomy
subject: FOS: Biological sciences
subject: 60310 Plant Systematics and Taxonomy
subject: 60408 Genomics

description: Plant species detected in more than 20 % of samples, excluding orchids (presence as % in total samples in parentheses).
Identifying river changes by river pattern events: a case study of the Lower Yellow River, China
Creators: name: Yan, Chaode
name: Li, Ziwei
name: Boota, Muhammad Waseem
name: Shi, Chunlong
name: Xu, Jikun
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Space Science
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Accurate and timely detection of river change attaches importance to regional ecological security. Since river change is a complex and dynamic process, there are difficulties to describe it properly. Inspired by geographic events research, river pattern events are innovatively proposed to quantify river change process, combining multi-dimensional information thoroughly. First, inter- and intra- events are defined by comparing typologies changes of river patterns. Afterwards, a river pattern events model (RPEM), integrating "Event types-Spatial locations-River patterns-Morphological features-Hydrological attributes", was proposed to maximally characterize river change process. River pattern events were detected using the object increment difference (OID), and were interpreted as the semantic information in realistic rivers. Experimental results in the Lower Yellow River (LYR) demonstrated that the proposed method achieves good performance in assessing the morphological and hydrological change process. River pattern events are expected to support rapid detection and dynamic analysis of regional and global river change.
Additional file 1 of Does continuing professional development enhance patient care? A survey of Irish based general practitioners
Creators: name: McBride, Adam
name: Collins, Claire
name: Osborne, Brian
name: McVeigh, Helen
Publisher: name: figshare
Year: 2022
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Cancer
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1.
De Boer et al. DNA metabarcoding of orchid-derived products reveals widespread illegal orchid trade. Proceedings of the Royal Society B. DOI: 10.1098/rspb.2017-1182. Electronic Supplementary Material (ESM) Text S1
Creators: name: Boer, Hugo J. De
name: Abdolbaset Ghorbani
name: Manzanilla, Vincent
name: Ancuta-Cristina Raclariu
name: Kreziou, Anna
name: Sarawut Ounjai
name: Maslin Osathanunkul
name: Gravendeel, Barbara
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 60301 Animal Systematics and Taxonomy
subject: FOS: Biological sciences
subject: 60310 Plant Systematics and Taxonomy
subject: 60408 Genomics

description: Detailed methods.
De Boer et al. DNA metabarcoding of orchid-derived products reveals widespread illegal orchid trade. Proceedings of the Royal Society B. DOI: 10.1098/rspb.2017-1182. Electronic Supplementary Material (ESM) Table S1
Creators: name: Boer, Hugo J. De
name: Abdolbaset Ghorbani
name: Manzanilla, Vincent
name: Ancuta-Cristina Raclariu
name: Kreziou, Anna
name: Sarawut Ounjai
name: Maslin Osathanunkul
name: Gravendeel, Barbara
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 60301 Animal Systematics and Taxonomy
subject: FOS: Biological sciences
subject: 60310 Plant Systematics and Taxonomy
subject: 60408 Genomics

description: Salep samples were randomly purchased to represent commercially available salep products with the objective to assess the level of adulterated and true orchid based products. The sampling includes a representation of producers and vendors, e.g., supermarkets, herbal stores, pharmacies, and markets.
Additional file 1 of Risk factors for placental malaria, sulfadoxine-pyrimethamine doses, and birth outcomes in a rural to urban prospective cohort study on the Bandiagara Escarpment and Bamako, Mali
Creators: name: Vincenz, Claudius
name: Dolo, Zachary
name: Saye, Serou
name: Lovett, Jennie L.
name: Strassmann, Beverly I.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Fig. S1. Relationship between maternal age and date of offspring birth. Linear fit line is bold; thinner lines indicate 95% confidence intervals around the mean.
Decoding Digital Curation for Cultural Heritage: A Survey and Extended Proposal
Creators: name: Karatas, Tugce
name: Lombardo, Vincenzo
Publisher: name: Zenodo
Year: 2020
Subjects: digital curation
cultural heritage
semantics
data curation
technologies

description: Digital curation in cultural heritage organizations is becoming more and more established as a practice as empirical research into tools, techniques, skills, standards and best practices in particular contexts emerge. Curators typically tackle technical obsolescence, ignorance of good practices, uncertainty over appropriate infrastructure as well as lack of resources. Digital curation activities are complex processes that involve diverse skills and techniques, software tools and systems, and a range of professional and paraprofessional practices. The lack of acknowledged models opens the way to the usage of algorithmic approaches as an alternative/support/aid to human curation, especially as personal filters and as generators of public experiences realized through machine learning and virtual reality tools. However, the relationship of curation with materials and their digital counterparts lacks an encompassing effective framework. Here, we claim that an encompassing framework of digital curation is strongly needed: this would provide and open to the development of software environments in support. It addresses all the phases that concern the digital curation activities, as well as broader technological factors impacting digital curation practice. Therefore, this research, on the one hand, formulates a definition of digital curation and then discusses the involved activities and the roles and responsibilities of the digital curators; on the other hand, it unpacks the notions of semantic encoding and argues for the importance of the data lifecycle and of metadata to digital curation. Finally, it addresses researcher behaviours and the ways in which multidisciplinarity, collective practice, and collaboration shape the sharing and reuse of data in the context of the knowledge transfer. In developing or following an appropriate digital curation workflow, designers should consider issues such as scope (what services will be offered and to which audiences), best user experience practices or community outreach or both, and model’s ability to represent work practices. The focus of the research will be on digital curation tools that are interactive, pervasive, multimodal, physical and social for further research on examining how we can better map human perceptions and experiences of the built environment. Although this is a mainly survey-type investigation, this research will also draw on other disciplines, including design, cultural heritage, science, and technology. It aims to surface similarities and differences in digital curation activities, as well as broader technological factors impacting digital curation practice.
description: This project is also related to a project called "Be- archaeo" which is funded by the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie, Grant Agreement N°. 823826
De Boer et al. DNA metabarcoding of orchid-derived products reveals widespread illegal orchid trade. Proceedings of the Royal Society B. DOI: 10.1098/rspb.2017-1182. Figure S1
Creators: name: Boer, Hugo J. De
name: Abdolbaset Ghorbani
name: Manzanilla, Vincent
name: Ancuta-Cristina Raclariu
name: Kreziou, Anna
name: Sarawut Ounjai
name: Maslin Osathanunkul
name: Gravendeel, Barbara
Publisher: name: The Royal Society
Year: 2017
Subjects: subject: 60301 Animal Systematics and Taxonomy
subject: FOS: Biological sciences
subject: 60310 Plant Systematics and Taxonomy
subject: 60408 Genomics

description: In eastern Mediterranean countries orchids continue to be collected from the wild for the production of salep, a beverage made of dried orchid tubers. In this study we used nrITS1 and nrITS2 DNA metabarcoding to identify orchid and other plant species present in 55 commercial salep products purchased in Iran, Turkey, Greece and Germany. Thirty samples yielded a total of 161 plant taxa, and 13 products (43%) contained orchid species and these belonged to 10 terrestrial species with tuberous roots. Another 70% contained the substitute ingredient Cyamopsis tetraganoloba (Guar). DNA metabarcoding using the barcoding markers nrITS1 and nrITS2 shows the potential of these markers and approach for identification of species used in salep products. The analysis of interspecific genetic distances between sequences of these markers for the most common salep orchid genera shows that species level identifications can be made with a high level of confidence. Understanding the species diversity and provenance of salep orchid tubers will enable the chain of commercialization of endangered species to be traced back to the harvesters and their natural habitats, and thus allow for targeted efforts to protect or sustainably use wild populations of these orchids.
MOESM2 of Anaplasma phagocytophilum evolves in geographical and biotic niches of vertebrates and ticks
Creators: name: Jaarsma, Ryanne
name: Sprong, Hein
name: Takumi, Katsuhisa
name: Kazimirova, Maria
name: Silaghi, Cornelia
name: Mysterud, Atle
name: Rudolf, Ivo
name: Beck, Relja
name: Földvári, Gábor
name: Tomassone, Laura
name: Groenevelt, Margit
name: Everts, Reinard
name: Rijks, Jolianne
name: Ecke, Frauke
name: Hörnfeldt, Birger
name: Modrý, David
name: Majerová, Karolina
name: Votýpka, Jan
name: Estrada-Peña, Agustín
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 2: Figure S1. The complete network of haplotypes of A. phagocytophilum with labels for every node, including the number of haplotype, carriers (ticks or vertebrates) and geographical origin. Symbols and colours in the network are identical to those in Fig. 2.
Additional file 2 of Risk factors for placental malaria, sulfadoxine-pyrimethamine doses, and birth outcomes in a rural to urban prospective cohort study on the Bandiagara Escarpment and Bamako, Mali
Creators: name: Vincenz, Claudius
name: Dolo, Zachary
name: Saye, Serou
name: Lovett, Jennie L.
name: Strassmann, Beverly I.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2: Fig. S2. Box plots of maternal age (A), offspring year of birth (B), and maternal pre-pregnancy BMI (C), by gravidity (multigravida or primigravida).