cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Radiation pressure on fluffy submicron-sized grains
Creators: name: Silsbee, Kedron
name: Draine, Bruce T.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: We investigate the claim that the ratio β of radiation pressure force to gravitational force on a dust grain in our solar system can substantially exceed unity for some grain sizes, provided that grain porosity is high enough. For model grains consisting of random aggregates of silicate spherules, we find that the maximum value of β is almost independent of grain porosity, but for small (<0.3 μm) grains, β actually decreases with increasing porosity. We also investigate the effect of metallic iron and amorphous carbon inclusions in the dust grains and find that while these inclusions do increase the radiation pressure cross-section, β remains below unity for grains with 3 pg of silicate material. These results affect the interpretation of the grain trajectories estimated from the {\it Stardust} mission, which were modeled assuming β values exceeding one. We find that radiation pressure effects are not large enough for particles Orion and Hylabrook captured by {\it Stardust} to be of interstellar origin given their reported impact velocities. We also consider the effects of solar radiation on transverse velocities and grain spin, and show that radiation pressure introduces both transverse velocities and equatorial spin velocities of several hundred meters per second for incoming interstellar grains at 2 AU. These transverse velocities are not important for modeling trajectories, but such spin rates may result in centrifugal disruption of aggregates.
OPERCULAR GLANDS OF THE LESSER WEEVER, TRACHINUS-VIPERA CV (TELEOSTEI, TRACHINOIDEA, TRACHINIDAE) .2. HISTOCHEMICAL AND HISTOENZYMOLOGICAL STUDY
Creators: name: Perriere, C.
name: Michel, C.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1987

Abstract
Additional file 3 of Optimal experimental designs for estimating genetic and non-genetic effects underlying infectious disease transmission
Creators: name: Pooley, Christopher
name: Marion, Glenn
name: Bishop, Stephen
name: Doeschl-Wilson, Andrea
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Additional file 3: Inversion of the observed Fisher information matrix. Description: This shows how the observed Fisher information matrix in Eq. (4) is inverted to give the results in Eqs. (6) and (7).
Impact of phosphorus ligand modification on transition metal coordination and homogeneous carbonylation catalysis
Creators: name: Tay Wei Peng, Dillon
Publisher: name: Imperial College London
Year: 2020

description: Subtle changes in phosphorus ligand structure have been known to lead to significant changes in metal-ligand coordination behaviour and subsequent catalytic performance. A combination of both experimental and computational techniques has been employed to study the influence of phosphorus ligand modification on its coordination behaviour and performance in homogeneous olefin carbonylation. The gem-dialkyl effect (also known as the Thorpe-Ingold effect) can be applied to C3-bridged bis(diphenylphosphine) ligands via geminal substitution of two alkyl groups (R) on the central carbon of the C3-bridge. Structurally, the gem-dialkyl effect has been observed to distort 6-membereded chelates formed in diphosphine-palladium(II) chloride complexes from a chair (R = H) to a half-chair (R = Me, Et, iPr) and eventually to a twist-boat (R = tBu) conformation. In terms of catalytic performance, the gem-dialkyl effect favours reductive hydroformylation to directly produce alcohols from olefins during palladium catalysed hydroformylation. The gem-dialkyl effect has also been observed to hinder isomerisation and promote reaction rate in palladium catalysed methoxycarbonylation of terminal olefins. Modification of the C2-linker from ethylene to phenyl in diphobane ligands has resulted in a dramatic shift in chemoselectivity from alcohols to aldehydes in palladium catalysed olefin hydroformylation. The competition between hydroformylation and alkoxycarbonylation in palladium catalysed olefin carbonylation has also been tuned by introducing substituents (X) on phenyl-bridged diphobanes to favour aldehyde (X = H), alcohol (X = OMe, OMe) or ester (X = CF3) products respectively. The testing of a series of ligands in ruthenium catalysed tandem reverse Water-Gas Shift-hydroformylation-reduction of olefins to alcohols has shown that bidentate ligands and higher monodentate ligand-to-metal ratios favour olefin hydrogenation. The choice of solvent has also been found to play a crucial role as high CO2 pressures at reaction conditions can expand the solvent, alter its physical properties and thus influence catalytic activity.
A note on the zeros of zeta and $L$-functions
Creators: name: Carneiro, Emanuel
name: Chandee, Vorrapan
name: Milinovich, Micah B.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 11M06, 11M26, 11M36, 11M41, 41A30

description: Let $πS(t)$ denote the argument of the Riemann zeta-function at the point $s=\tfrac12+it$. Assuming the Riemann hypothesis, we give a new and simple proof of the sharpest known bound for $S(t)$. We discuss a generalization of this bound for a large class of $L$-functions including those which arise from cuspidal automorphic representations of GL($m$) over a number field. We also prove a number of related results including bounding the order of vanishing of an $L$-function at the central point and bounding the height of the lowest zero of an $L$-function.
(3934) Janet Tassie
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
New data on the attachment of teeth in the Angler fish Lophius piscatorius (Actinopterygii: Teleostei: Lophiidae)
Creators: name: MEUNIER, François J.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2015

description: The angler fish, Lophius piscatorius (Lophiidae), has sharp caniniform teeth that are fixed on jaws and various other splanchocranian bones. The teeth are 3 to 4 times longer than wide; they are more or less curved the tip being turned toward the buccal cavity. They are constituted of a cone of orthodentine with a cap of enameloid substance at their tip. The dentine of the teeth is divided in two layers: an inner layer of circumpulpal dentine and an external one of pallial dentine. Main buccal Lophius's teeth have a mixed ankylosis and hinged attachment; but the ankylosed part of teeth, localised on the labial side, is constituted of dentine folds: so it is a plicidentine organisation. Some other teeth that are completely ankylosed show dentine folds all around the pulp cavity. This morphological feature is a new example of plicidentine in the actinopterygian lineage, in addition to Lepisosteidae, Arapaimadidae, Characidae and Erythrinidae.
title: Wind on buildings
Creators: name: Dalgliesh, W. A.
name: Boyd, D. W.
Publisher: name: National Research Council of Canada. Division of Building Research
Year: 1962
Subjects: subject: Air flow/Wind pressure
valueUri: urn:ircsubjects:IRC0344
subject: Surcharges dues au vent/écoulement d'air
valueUri: urn:ircsubjects:IRC0344
subject: wind loads
subject: surcharges de vent
subject: high rise buildings
subject: construction élevée

description: Some of the features of wind near the surface of the earth are briefly described in this Digest. Particular attention is given to gustiness and to the rates of increase of both mean wind speeds and peak gust speeds with increases in height. A method of computing design wind speeds from wind observations available in Canada is outlined.
Additional file 4 of Optimal experimental designs for estimating genetic and non-genetic effects underlying infectious disease transmission
Creators: name: Pooley, Christopher
name: Marion, Glenn
name: Bishop, Stephen
name: Doeschl-Wilson, Andrea
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Additional file 4: Derivation of standard deviations for recoverability SNP effect. Description: The standard deviation for the SNP effect on recoverability ar is derived.
Uncovering Biphasic Catalytic Mode of C 5 -epimerase in Heparan Sulfate Biosynthesis
Creators: name: Xu, Yongmei
name: Sheng, Juzheng
name: Huang, Xuefei
name: Dulaney, Steven B.
name: Liu, Jian
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Heparan sulfate (HS), a highly sulfated polysaccharide, is biosynthesized through a pathway involving several enzymes. C5-epimerase (C5-epi) is a key enzyme in this pathway. C5-epi is known for being a two-way catalytic enzyme, displaying a “reversible” catalytic mode by converting a glucuronic acid to an iduronic acid residue, and vice versa. Here, we discovered that C5-epi can also serve as a one-way catalyst to convert a glucuronic acid to an iduronic acid residue, displaying an “irreversible” catalytic mode. Our data indicated that the reversible or irreversible catalytic mode strictly depends on the saccharide substrate structures. The biphasic mode of C5-epi offers a novel mechanism to regulate the biosynthesis of HS with the desired biological functions.
(3936) Ann Niven
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Critical surface of the hexagonal polygon model
Creators: name: Grimmett, Geoffrey R.
name: Li, Zhongyang
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: Combinatorics (math.CO)
subject: Probability (math.PR)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 82B20, 60K35, 05C70

description: The hexagonal polygon model arises in a natural way via a transformation of the 1-2 model on the hexagonal lattice, and it is related to the high temperature expansion of the Ising model. There are three types of edge, and three corresponding parameters $α,β,γ>0$. By studying the long-range order of a certain two-edge correlation function, it is shown that the parameter space $(0,\infty)^3$ may be divided into subcritical and supercritical regions, separated by critical surfaces satisfying an explicitly known formula. This result complements earlier work on the Ising model and the 1-2 model. The proof uses the Pfaffian representation of Fisher, Kasteleyn, and Temperley for the counts of dimers on planar graphs.
description: v2: minor changes and corrections
FEDORA Podcasts - Deliverable 6.5
Creators: name: Conti, Francesca
name: Troncoso, Andrea
name: Tola, Elisabetta
Publisher: name: Zenodo
Year: 2022
Subjects: Podcast
Dissemination
Futures thinking
Science education

description: As part of the original voice that the FEDORA project has set as a purpose for reaching its audiences in a compelling and meaningful way, the “FEDORA podcast” is a communication tool that will share the views, narratives and questions that the project intends to address. Deliverable 6.5 “FEDORApodcast” explains the aim of this dissemination product, as well as its editorial plan and shares a trailer that invites and explains the contents of the series of audios that will be released between September 2022 and June 2023. This deliverable is the 5th document delivered by WP6, “Behind the scenes: Communicating and Disseminating FEDORA in its making”, part of task 6.4, “Multimedia production”, and is led by formicablu.
Wilms Tumor Gene on X Chromosome (WTX) Inhibits Degradation of NRF2 Protein through Competitive Binding to KEAP1 Protein
Creators: name: Tang, Xiaobo
name: Yan, Feng
name: Davison, James M.
name: James, Richard G.
name: Dawson, David W.
name: Houck, Scott A.
name: Major, Michael B.
name: Moon, Randall T.
name: Camp, Nathan D.
name: Zheng, Ning
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Background: KEAP1 is a ubiquitin ligase adaptor that promotes the ubiquitination and degradation of NRF2, a transcription factor that drives the antioxidant response.Results: Wilms tumor gene on the X chromosome (WTX) stabilizes NRF2 by competing with NRF2 for binding to KEAP1.Conclusion: WTX regulates the antioxidant response.Significance: This study reveals a novel regulatory mechanism governing the antioxidant response.WTX is a tumor suppressor protein that is lost or mutated in up to 30% of cases of Wilms tumor. Among its known functions, WTX interacts with the β-transducin repeat containing family of ubiquitin ligase adaptors and promotes the ubiquitination and degradation of the transcription factor β-catenin, a key control point in the WNT/β-catenin signaling pathway. Here, we report that WTX interacts with a second ubiquitin ligase adaptor, KEAP1, which functions to regulate the ubiquitination of the transcription factor NRF2, a key control point in the antioxidant response. Surprisingly, we find that unlike its ability to promote the ubiquitination of β-catenin, WTX inhibits the ubiquitination of NRF2. WTX and NRF2 compete for binding to KEAP1, and thus loss of WTX leads to rapid ubiquitination and degradation of NRF2 and a reduced response to cytotoxic insult. These results expand our understanding of the molecular mechanisms of WTX and reveal a novel regulatory mechanism governing the antioxidant response.
Incidence, aetiology and inspective notes of cottony in Mediterranean deep-water rose shrimp Parapenaeus longirostris (Crustacea: Decapoda)
Creators: name: PANEBIANCO, Antonio
name: GIARRATANA, Filippo
name: MUSCOLINO, Daniele
name: ZIINO, Graziella
name: BENINATI, Chiara
name: FALSONE, Luigi
name: CASALE, Gianfranco
name: GIUFFRIDA, Alessandro
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2015

description: Cottony of shrimp muscle is a pathological condition characterized by a progressive white opacity of musculature. Several causes have been accounted for this condition, including viruses, bacteria and parasites. In the present study incidence and etiology of this muscle alteration was evaluated in deep-water rose shrimp (Parapenaeus longirostris) captured in the Mediterranean Sea. A total of 190,000 either fresh or frozen P. longirostris coming from fishing area FAO 37-1 (n = 95.000) and 37-2 (n = 95.000) were evaluated for cottony by direct inspection, and lesion studied through histology and transmission electron microscope analysis. A comparison of bacteria found in specimens with and without cottony was also performed. A total of 126 cases (0.07%) of opaque muscle tissue were found. In all cases histopathological and ultrastructural observations revealed the presence of uninucleate microsporidian spores. No bacteriological differences were observed between cottony and non-infected shrimps. Although cottony does not represent a public health risk because these parasites do not constitute a zoonotic hazard for the consumer, it renders shrimps unmarketable and inedible.
Secret Key Generation with One Communicator and a One-Shot Converse via Hypercontractivity
Creators: name: Liu, Jingbo
name: Cuff, Paul
name: Verdu, Sergio
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: A new model of multi-party secret key agreement is proposed, in which one terminal called the communicator can transmit public messages to other terminals before all terminals agree on a secret key. A single-letter characterization of the achievable region is derived in the stationary memoryless case. The new model generalizes some other (old and new) models of key agreement. In particular, key generation with an omniscient helper is the special case where the communicator knows all sources, for which we derive a zero-rate one-shot converse for the secret key per bit of communication.
description: slightly extended version of ISIT 2015 paper
Additional file 5 of Optimal experimental designs for estimating genetic and non-genetic effects underlying infectious disease transmission
Creators: name: Pooley, Christopher
name: Marion, Glenn
name: Bishop, Stephen
name: Doeschl-Wilson, Andrea
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Additional file 5: Derivation of standard deviations in the dominance parameters Δg, Δf and Δr.
Human coronavirus OC43-elicited CD4+ T cells protect against SARS-CoV-2 in HLA transgenic mice
Creators: name: Shafee, Norazizah
name: Shresta, Sujan
name: Valentine, Kristen
name: Pinto, Paolla Beatriz Almeida
name: Dobaczewska, Katarzyna
name: Laffey, Brett
name: Baric, Ralph S.
name: Ollmann Saphire, Erica
name: Gonzalez, Andrew
name: Miller, Robyn
name: Timis, Julia
name: Mikulski, Zbigniew
name: McArdle, Sara
name: Olmedillas, Eduardo
name: Dos Santos Alves, Rúbens Prince
name: Regla-Nava, Jose Angel
name: Elong Ngono, Annie
name: Landeras-Bueno, Sara
name: Kim, Kenneth
name: Nguyen, Michael N.
name: Maule, Erin
name: Leist, Sarah R.
Publisher: name: Springer Nature
Year: 2024

description: SARS-CoV-2-reactive T cells are detected in some healthy unexposed individuals. Human studies indicate these T cells could be elicited by the common cold coronavirus OC43. To directly test this assumption and define the role of OC43-elicited T cells that are cross-reactive with SARS-CoV-2, we develop a model of sequential infections with OC43 followed by SARS-CoV-2 in HLA-B*0702 and HLA-DRB1*0101 Ifnar1-/- transgenic mice. We find that OC43 infection can elicit polyfunctional CD8+ and CD4+ effector T cells that cross-react with SARS-CoV-2 peptides. Furthermore, pre-exposure to OC43 reduces subsequent SARS-CoV-2 infection and disease in the lung for a short-term in HLA-DRB1*0101 Ifnar1-/- transgenic mice, and a longer-term in HLA-B*0702 Ifnar1-/- transgenic mice. Depletion of CD4+ T cells in HLA-DRB1*0101 Ifnar1-/- transgenic mice with prior OC43 exposure results in increased viral burden in the lung but no change in virus-induced lung damage following infection with SARS-CoV-2 (versus CD4+ T cell-sufficient mice), demonstrating that the OC43-elicited SARS-CoV-2 cross-reactive T cell-mediated cross-protection against SARS-CoV-2 is partially dependent on CD4+ T cells. These findings contribute to our understanding of the origin of pre-existing SARS-CoV-2-reactive T cells and their effects on SARS-CoV-2 clinical outcomes, and also carry implications for development of broadly protective betacoronavirus vaccines.
Additional file 6 of Optimal experimental designs for estimating genetic and non-genetic effects underlying infectious disease transmission
Creators: name: Pooley, Christopher
name: Marion, Glenn
name: Bishop, Stephen
name: Doeschl-Wilson, Andrea
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Additional file 6: Fig. S1. Shows how the probability of epidemic extinction varies as a function of the number of seeder individuals Nseed for different basic reproductive ratios R0.
17β-Estradiol Inhibits Phosphorylation of Stromal Interaction Molecule 1 (STIM1) Protein: IMPLICATION FOR STORE-OPERATED CALCIUM ENTRY AND CHRONIC LUNG DISEASES
Creators: name: Watson, Michael J.
name: Gilmore, Rodney C.
name: Sheridan, John T.
name: Tarran, Robert
name: Archer, Christopher B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Sex plays a significant role in the development of lung diseases including asthma, cancer, chronic bronchitis, and cystic fibrosis. In cystic fibrosis, 17β-estradiol (E2) may inhibit store-operated Ca2+ entry (SOCE) to impinge upon airway secretions, leaving females at greater risk of contracting lung infections. Stromal interaction molecule 1 (STIM1)-mediated SOCE is essential for cell homeostasis and regulates numerous processes including cell proliferation, smooth muscle contraction, and secretion. E2 can signal nongenomically to modulate Ca2+ signaling, but little is known of the underlying mechanisms. We found that E2 exposure inhibited STIM1 translocation in airway epithelia, preventing SOCE. This correlated with a decrease in STIM1-STIM1 FRET and STIM1 mobility in E2-exposed HEK293T cells co-expressing estrogen receptor α. We also examined the role of STIM1 phosphorylation in E2-mediated inhibition of STIM1 mobility. STIM1 is basally phosphorylated at serine 575, which is required for SOCE. Exposure to E2 significantly decreased STIM1 serine phosphorylation. Mutating serine 575 to an alanine blocked STIM1 phosphorylation, reduced basal STIM1 mobility, and rendered STIM1 insensitive to E2. These data indicate that E2 can signal nongenomically by inhibiting basal phosphorylation of STIM1, leading to a reduction in SOCE.
ÉTUDE HISTOLOGIQUE DU DÉVELOPPEMENT DE NANOMIA BIJUGA (CHIAJE, 1841), SIPHONOPHORE PHYSONECTE, AGALMIDAE.
Creators: name: CARRÉ, Daniele
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1969

description: The 'histological study of the first developmental stages of the Siphonophora Nanomia bijuga shows that the segmentation leads to a sterroblastula which changes into a gastrula, by primary delamination. The gastrula evolves into a planula, the ectodermic cells of the anterior pole of which invaginate, to form the internal ectoderm of the pneumatophore. The différenciation of this pneumatophoreisdescribed.
The author studies also the different kinds of glandular cells of the primary gastrozoid and the development of gonophores in young colonies.
Finally, some experiments are described, showing the possibility of regulation in thelarvae.
(3938) Elizabeth Begg
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 7 of Optimal experimental designs for estimating genetic and non-genetic effects underlying infectious disease transmission
Creators: name: Pooley, Christopher
name: Marion, Glenn
name: Bishop, Stephen
name: Doeschl-Wilson, Andrea
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Additional file 7: Further details for the single contact group design. Description: Provides analytical expressions for the standard deviations in the SNP effect parameters ag, af and ar for the single contact group design.
A Link between Dimerization and Autophosphorylation of the Response Regulator PhoB
Creators: name: Silversmith, Ruth E.
name: Creager-Allen, Rachel L.
name: Bourret, Robert B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Response regulator proteins within two-component signal transduction systems are activated by phosphorylation and can catalyze their own covalent phosphorylation using small molecule phosphodonors. To date, comprehensive kinetic characterization of response regulator autophosphorylation is limited to CheY, which follows a simple model of phosphodonor binding followed by phosphorylation. We characterized autophosphorylation of the response regulator PhoB, known to dimerize upon phosphorylation. In contrast to CheY, PhoB time traces exhibited an initial lag phase and gave apparent pseudo-first order rate constants that increased with protein concentration. Furthermore, plots of the apparent autophosphorylation rate constant versus phosphodonor concentration were sigmoidal, as were PhoB binding isotherms for the phosphoryl group analog BeF3−. Successful mathematical modeling of the kinetic data necessitated inclusion of the formation of a PhoB heterodimer (one phosphorylated and one unphosphorylated monomer) with an enhanced rate of phosphorylation. Specifically, dimerization constants for the PhoB heterodimer and homodimer (two phosphorylated monomers) were similar, but the rate constant for heterodimer phosphorylation was ∼10-fold higher than for the monomer. In a test of the model, disruption of the known PhoBN dimerization interface by mutation led to markedly slower and noncooperative autophosphorylation kinetics. Furthermore, phosphotransfer from the sensor kinase PhoR was enhanced by dimer formation. Phosphorylation-mediated dimerization allows many response regulators to bind to tandem DNA-binding sites and regulate transcription. Our data challenge the notion that response regulator dimers primarily form between two phosphorylated monomers and raise the possibility that response regulator heterodimers containing one phosphoryl group may participate in gene regulation.
XtalFluor-E: A useful and versatile reagent in organic transformations
Creators: name: Heravi, Majid Mommahed
name: Mohammadkhani, Leyla
Publisher: name: figshare
Year: 2020
Subjects: subject: 30299 Inorganic Chemistry not elsewhere classified
subject: FOS: Chemical sciences
subject: Inorganic Chemistry
subject: 30203 Inorganic Green Chemistry
subject: 30302 Nanochemistry and Supramolecular Chemistry
subject: 30502 Natural Products Chemistry
subject: 30205 Non-metal Chemistry
subject: Nuclear Chemistry
subject: 30303 Optical Properties of Materials
subject: 30503 Organic Chemical Synthesis
subject: Organic Chemistry
subject: 30599 Organic Chemistry not elsewhere classified
subject: 30504 Organic Green Chemistry

description: XtalFluor-E, [Et2NSF2]BF4, is best known as a useful, versatile and inexpensive commercially available reagent for the deoxyfluorination of carbonyl compounds and alcohols. Although XtalFluor-E is commonly used in combination with an exogenous fluoride source as a deoxofluorinating reagent, it has also been widely employed in other chemical transformations such as dehydration, cyclodehydration, ring expansion, formylation, and proto-functionalization, etc. This Review aims to provide an overview for the applications of XtalFluor-E as a reagent in organic synthesis, including its physical properties, futures, and its unique roles beyond than being just as a deoxofluorinating reagent in organic transformation.
title: Fondations des maisons
Creators: name: Crawford, C. B.
Publisher: name: Conseil national de recherches du Canada. Division des recherches en construction
Year: 1962
Subjects: subject: Basements and foundations
valueUri: urn:ircsubjects:IRC0320
subject: Sous-sol et fondations
valueUri: urn:ircsubjects:IRC0320
subject: foundations
subject: fondation (ouvrage)
subject: single family dwellings
subject: maison unifamiliale
subject: construction sites
subject: chantier de construction
subject: selection
subject: soils
subject: sol (terre)
subject: fine grained soils
subject: sol à grains fins
subject: basements
subject: sous sol (bâtiment)

description: On cherche dans la présente notice à montrer les éléments essentiels du choix d'un emplacement de construction et les avantages à tirer de l'étude du sol avant la construction de chaque maison. On a donnée en référence la terminologie standard qui a été mise au point pour faciliter l'inscription des renseignements concernant le sol. On a montré que des solutions exceptionnellement simples existent pour résoudre les problèmes communs qui se posent dans le cadre des difficultés de construction inhérentes aux divers types de sol.
BIOLOGY AND ECOLOGY OF 3 SPECIES OF INTERTIDAL GASTROPOD MOLLUSKS, RISSOA-PARVA, BARLEEIA-UNIFASCIATA, AND BITTIUM-RETICULATUM .1. POPULATION-STRUCTURE AND DYNAMICS
Creators: name: Borja, A.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1986

Abstract
The quantum brachistochrone problem for an arbitrary spin in a magnetic field
Creators: name: Kuzmak, A. R.
name: Tkachuk, V. M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We consider quantum brachistochrone evolution for a spin-$s$ system on rotational manifolds. Such manifolds are determined by the rotation of the eigenstates of the operator of projection of spin-$s$ on some direction. The Fubini-Study metrics of these manifolds are those of spheres with radii dependent on the value of the spin and on the value of the spin projection. The conditions for optimal evolution of the spin-$s$ system on rotational manifolds are obtained.
description: Accepted for publication in Phys. Lett. A
(3935) William Cunningham
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 8 of Optimal experimental designs for estimating genetic and non-genetic effects underlying infectious disease transmission
Creators: name: Pooley, Christopher
name: Marion, Glenn
name: Bishop, Stephen
name: Doeschl-Wilson, Andrea
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Additional file 8: Fig. S2. Impact of changing R0. In additional file 8, we numerically investigate how changing R0 affects the fraction of infected contacts ϕ and the optimal design choices outlined in Fig. 2.
ULTRASTRUCTURE DU MUSCLE DE LA QUEUE DE L'APPENDICULAIRE OIKOPLEURA LONGICAUDA VOGT. LES LIMITES CELLULAIRES ; LES DISQUES INTERCALAIRES
Creators: name: BOGORAZE, Dimitri
name: TUZET, Odette
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1969

Abstract
Summary of the Second Workshop on Liquid Argon Time Projection Chamber Research and Development in the United States
Creators: name: Acciarri, R.
name: Adamowski, M.
name: Artrip, D.
name: Baller, B.
name: Bromberg, C.
name: Cavanna, F.
name: Carls, B.
name: Chen, H.
name: Deptuch, G.
name: Epprecht, L.
name: Dharmapalan, R.
name: Foreman, W.
name: Hahn, A.
name: Johnson, M.
name: Jones, B. J. P.
name: Junk, T.
name: Lang, K.
name: Lockwitz, S.
name: Marchionni, A.
name: Mauger, C.
name: Montanari, C.
name: Mufson, S.
name: Nessi, M.
name: Back, H. Olling
name: Petrillo, G.
name: Pordes, S.
name: Raaf, J.
name: Rebel, B.
name: Sinins, G.
name: Soderberg, M.
name: Spooner, N.
name: Stancari, M.
name: Strauss, T.
name: Terao, K.
name: Thorn, C.
name: Tope, T.
name: Toups, M.
name: Urheim, J.
name: Van de Water, R.
name: Wang, H.
name: Wasserman, R.
name: Weber, M.
name: Whittington, D.
name: Yang, T.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The second workshop to discuss the development of liquid argon time projection chambers (LArTPCs) in the United States was held at Fermilab on July 8-9, 2014. The workshop was organized under the auspices of the Coordinating Panel for Advanced Detectors, a body that was initiated by the American Physical Society Division of Particles and Fields. All presentations at the workshop were made in six topical plenary sessions: $i)$ Argon Purity and Cryogenics, $ii)$ TPC and High Voltage, $iii)$ Electronics, Data Acquisition and Triggering, $iv)$ Scintillation Light Detection, $v)$ Calibration and Test Beams, and $vi)$ Software. This document summarizes the current efforts in each of these areas. It primarily focuses on the work in the US, but also highlights work done elsewhere in the world.
description: 49 pages, 29 figures, 1 table
Mosaic community dynamics on Juan de Fuca Ridge sulphide edifices : substratum, temperature and implications for trophic structure
Creators: name: SARRAZIN, Jozée
name: LEVESQUE, Christian
name: JUNIPER, S. Kim
name: TIVEY, Margaret K.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2002

Abstract
A Pathophysiologic Role for Epidermal Growth Factor Receptor in Pemphigus Acantholysis
Creators: name: Jolly, Puneet S.
name: Amagai, Masayuki
name: Bektas, Meryem
name: Rubenstein, David S.
name: Berkowitz, Paula
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: The pemphigus family of autoimmune bullous disorders is characterized by autoantibody binding to desmoglein 1 and/or 3 (dsg1/dsg3). In this study we show that EGF receptor (EGFR) is activated following pemphigus vulgaris (PV) IgG treatment of primary human keratinocytes and that EGFR activation is downstream of p38 mitogen-activated protein kinase (p38). Inhibition of EGFR blocked PV IgG-triggered dsg3 endocytosis, keratin intermediate filament retraction, and loss of cell-cell adhesion in vitro. Significantly, inhibiting EGFR prevented PV IgG-induced blister formation in the passive transfer mouse model of pemphigus. These data demonstrate cross-talk between dsg3 and EGFR, that this cross-talk is regulated by p38, and that EGFR is a potential therapeutic target for pemphigus. Small-molecule inhibitors and monoclonal antibodies directed against EGFR are currently used to treat several types of solid tumors. This study provides the experimental rationale for investigating the use of EGFR inhibitors in pemphigus.
Monthly monitoring of length-weight relationships of allis shad (Alosa immaculata Bennett, 1835), horse mackerel (Trachurus mediterraneus Steindachner, 1868) and sprat (Sprattus sprattus Linnaeus, 1758) from the Southern Black Sea, Turkey
Creators: name: ÖZDEMİR, Süleyman
name: ERDEM, Ercan
name: BİRİNCİ ÖZDEMIR, Zekiye
name: AKSU, Hakan
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2015

description: Length-weight relationships are presented monthly for allis shad (Alosa immaculata), horse mackerel (Trachurus mediterraneus) and sprat (Sprattus sprattus) sampled with a commercial pelagic trawl vessel at depths ranging from 20 to 80 m between October 2008 and May 2009 in Black Sea, Turkey. The mean monthly values of the exponent b of the length- weight relationships ranged from 3.043 to 3.658 for allis shad, from 3.016 to 3.357 for horse mackerel and from 2.813 to 3.253 for sprat. Taking into account monthly confidence intervals, the length-weight relationships generally indicated a positive allometric growth in allis shad but an isometric growth in February, April and May 2009; it indicated a positive allometric growth in horse mackerel except in November and December 2008 (isometric growth), whereas it denoted isometric growth in sprat in October 2008, negative allometric growth from November 2008 to February 2009, isometric growth again in March 2009 and positive allometric growth in April and May 2009. Results showed that b value of allis shad, horse mackerel and sprat varied with season in the Black Sea.
Aminoacylating Urzymes Challenge the RNA World Hypothesis
Creators: name: Francklyn, Christopher
name: Li, Li
name: Carter Jr., Charles W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: We describe experimental evidence that ancestral peptide catalysts substantially accelerated development of genetic coding. Structurally invariant 120–130-residue Urzymes (Ur = primitive plus enzyme) derived from Class I and Class II aminoacyl-tRNA synthetases (aaRSs) acylate tRNA far faster than the uncatalyzed rate of nonribosomal peptide bond formation from activated amino acids. These new data allow us to demonstrate statistically indistinguishable catalytic profiles for Class I and II aaRSs in both amino acid activation and tRNA acylation, over a time period extending to well before the assembly of full-length enzymes and even further before the Last Universal Common Ancestor. Both Urzymes also exhibit ∼60% of the contemporary catalytic proficiencies. Moreover, they are linked by ancestral sense/antisense genetic coding, and their evident modularities suggest descent from even simpler ancestral pairs also coded by opposite strands of the same gene. Thus, aaRS Urzymes substantially pre-date modern aaRS but are, nevertheless, highly evolved. Their unexpectedly advanced catalytic repertoires, sense/antisense coding, and ancestral modularities imply considerable prior protein-tRNA co-evolution. Further, unlike ribozymes that motivated the RNA World hypothesis, Class I and II Urzyme·tRNA pairs represent consensus ancestral forms sufficient for codon-directed synthesis of nonrandom peptides. By tracing aaRS catalytic activities back to simpler ancestral peptides, we demonstrate key steps for a simpler and hence more probable peptide·RNA development of rapid coding systems matching amino acids with anticodon trinucleotides.
(3932) Janet Sellatly
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 9 of Optimal experimental designs for estimating genetic and non-genetic effects underlying infectious disease transmission
Creators: name: Pooley, Christopher
name: Marion, Glenn
name: Bishop, Stephen
name: Doeschl-Wilson, Andrea
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Computational Biology

description: Additional file 9: Fig. S3. Further details for the “pure” design. Description: Provides analytical expressions for the standard deviations in the SNP effect parameters ag, af and ar and dominance parameters Δg, Δf and Δr for the “pure” design.
Symmetry Conserving Purification of Quantum States within the Density Matrix Renormalization Group
Creators: name: Nocera, A.
name: Alvarez, G.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The density matrix renormalization group (DMRG) algorithm was originally designed to efficiently compute the zero temperature or ground-state properties of one dimensional strongly correlated quantum systems. The development of the algorithm at finite temperature has been a topic of much interest, because of the usefulness of thermodynamics quantities in understanding the physics of condensed matter systems, and because of the increased complexity associated with efficiently computing temperature-dependent properties. The ancilla method is a DMRG technique that enables the computation of these thermodynamic quantities. In this paper, we review the ancilla method, and improve its performance by working on reduced Hilbert spaces and using canonical approaches. We furthermore explore its applicability beyond spins systems to t-J and Hubbard models.
description: 10 pages, 7 figures
Supplemental Material for Bazzicalupo et al., 2020
Creators: name: Bazzicalupo, Anna L.
name: Thomas, Mallory
name: Munro-Ehrlich, Robert Mason
name: Branco, Sara
Publisher: name: GSA Journals
Year: 2020
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences

description: Supplementary figures and tables for G3/2020/401735
(3933) John Irvine
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Oxalyl Chloride: A Versatile Reagent in Organic Transformations
Creators: name: Heravi, Majid Mommahed
name: Mohammadkhani, Leyla
Publisher: name: figshare
Year: 2020
Subjects: subject: Organic Chemistry
subject: FOS: Chemical sciences
subject: 30599 Organic Chemistry not elsewhere classified
subject: 30504 Organic Green Chemistry
subject: 39904 Organometallic Chemistry
subject: 30699 Physical Chemistry not elsewhere classified
subject: 30302 Nanochemistry and Supramolecular Chemistry

description: Oxalyl chloride, (COCl)2, as an inexpensive commercially available chemical is one of the most versatile applicable organic reagents in chemical transformations. It is also employed extensively in various chemical industries. It is employed in various chemical transformations such as chlorination, oxidation, reduction, dehydration, decarboxylation, and formylation reactions as well as ring cleavage of epoxides. During the past decades, numerous procedures using (COCl)2 as reagent have been developed and published. However, its importance has largely been overlooked by the absence of a comprehensive review in chemical literature dealing with its application in organic transformations and its utilization in the chemical industry. This Review aims to provide an overview for the applications of oxalyl chloride in organic synthesis, including its physical properties, synthesis, as well as its unique roles as the reagent in organic reactions, covering the literature over the past 103 years (from 1916 to date).