cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Hemiancistrus daguae
Creators: name: Ardila, Carlos
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Siluriformes
Loricariidae
Hemiancistrus
Hemiancistrus daguae

description: Hemiancistrus daguae
: FMNH-56052, Holotype, 60.4 mm SL, Colombia, Caldas. FMNH-56053, 3 Paratypes, 32.3–75.8 mm SL, Colombia, Caldas. FMNH-56054, 2 Paratypes, 33.6–65.9 mm SL, Colombia, Caldas.
description: Published as part of Ardila, Carlos, 2017, A new species of the catfish genus Cordylancistrus (Siluriformes, Loricariidae) from the Sierra Nevada de Santa Marta, Colombia, pp. 256-266 in Zootaxa 4329 (3) on page 265, DOI: 10.11646/zootaxa.4329.3.4, http://zenodo.org/record/1002500
ReDas: A Lightweight Architecture for Supporting Fine-Grained Reshaping and Multiple Dataflows on Systolic Array
Creators: name: Han, Meng
name: Wang, Liang
name: Xiao, Limin
name: Cai, Tianhao
name: Wang, Zeyu
name: Xu, Xiangrong
name: Zhang, Chenhao
Publisher: name: arXiv
Year: 2023
Subjects: subject: Hardware Architecture (cs.AR)
subject: FOS: Computer and information sciences

description: The systolic accelerator is one of the premier architectural choices for DNN acceleration. However, the conventional systolic architecture suffers from low PE utilization due to the mismatch between the fixed array and diverse DNN workloads. Recent studies have proposed flexible systolic array architectures to adapt to DNN models. However, these designs support only coarse-grained reshaping or significantly increase hardware overhead. In this study, we propose ReDas, a flexible and lightweight systolic array that supports dynamic fine-grained reshaping and multiple dataflows. First, ReDas integrates lightweight and reconfigurable roundabout data paths, which achieve fine-grained reshaping using only short connections between adjacent PEs. Second, we redesign the PE microarchitecture and integrate a set of multi-mode data buffers around the array. The PE structure enables additional data bypassing and flexible data switching. Simultaneously, the multi-mode buffers facilitate fine-grained reallocation of on-chip memory resources, adapting to various dataflow requirements. ReDas can dynamically reconfigure to up to 129 different logical shapes and 3 dataflows for a 128x128 array. Finally, we propose an efficient mapper to generate appropriate configurations for each layer of DNN workloads. Compared to the conventional systolic array, ReDas can achieve about 4.6x speedup and 8.3x energy-delay product (EDP) reduction.
description: 14 pages, 22 figures, journal
Oncorhynchus clarkii
Creators: name: Love, Milton S.
name: Bizzarro, Joseph J.
name: Cornthwaite, Maria
name: Frable, Benjamin W.
name: Maslenikov, Katherine P.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Salmoniformes
Salmonidae
Oncorhynchus
Oncorhynchus clarkii

description: Oncorhynchus clarkii (Richardson, 1836).
Cutthroat Trout. To 99.1 cm (39 in) TL (Morrow 1980). Outer coast of Kenai Peninsula, northern Gulf of Alaska (Behnke 1992) to Eel River, northern California (Morrow 1980). At sea, stays close to home streams (Mecklenburg et al. 2002). Anadromous. Parasalmo clarkii (Richardson, 1836) is used by most Russian authors and by Fricke et al. (2020).
description: Published as part of Love, Milton S., Bizzarro, Joseph J., Cornthwaite, Maria, Frable, Benjamin W. & Maslenikov, Katherine P., 2021, Checklist of marine and estuarine fishes from the Alaska-Yukon Border, Beaufort Sea, to Cabo San Lucas, Mexico, pp. 1-285 in Zootaxa 5053 (1) on page 53, DOI: 10.11646/zootaxa.5053.1.1, http://zenodo.org/record/5578008
Wie wird das Asylwesen menschlicher?
Creators: name: Staffler, Armin
Publisher: name: Melusina Press
Year: 2024
Subjects: theater
asyl

description: Transkultureller Theaterschauplatz: Grenzen und die Odyssee Fliehender –
 Interdisziplinäre Überlegungen
description: Der folgende Artikel schildert im Wesentlichen die Tage zwischen 1. und 7. September
 2015. In dieser Zeit entstand ein Theater-Projekt zum Thema „Asyl in Tirol“, das vom
 kanadischen Theatermacher David Diamond geleitet wurde. Er begleitet eine Gruppe von
 Menschen, die das Thema aus unterschiedlichen Gründen unmittelbar betrifft, um mit
 ihnen Stücke zu entwickeln, diese zu proben und aufzuführen, um sie noch während der
 Aufführung mit dem Publikum weiter zu bearbeiten. Diese Art des Theaters nennt sich
 Forumtheater. Die zentrale Frage des Projekts lautete: Wie lässt sich das Asylwesen
 menschlicher gestalten?
Small system flow measurements from the PHENIX experiment at RHIC
Creators: name: Lim, Sanghoon
Publisher: name: Zenodo
Year: 2024
Subjects: aum24
phenix
small systems
p+al
p+au
d+au
3he+au
elliptic
flow
correlations
mid-rapidity
forward-rapidity
backward-rapidity
multiplicity

description: Talk presented at the flow and vorticity workshop at the RHIC/AGS Annual Users' Meeting 2024
Causal oscillations in the visual thalamo-cortical network in sustained attention in ferrets
Creators: name: Ramasamy, Nivetha S
name: Radtke-Schuller, Susanne
name: Frohlich, Flavio
name: Zhou, Zhe C
name: Huang, Wei A
name: Stitt, Iain M
Publisher: name: Elsevier
Year: 2024

description: Sustained visual attention allows us to process and react to unpredictable, behaviorally relevant sensory input. Sustained attention engages communication between the higher-order visual thalamus and its connected cortical regions. However, it remains unclear whether there is a causal relationship between oscillatory circuit dynamics and attentional behavior in these thalamo-cortical circuits. By using rhythmic optogenetic stimulation in the ferret, we provide causal evidence that higher-order visual thalamus coordinates thalamo-cortical and cortico-cortical functional connectivity during sustained attention via spike-field phase locking. Increasing theta but not alpha power in the thalamus improved accuracy and reduced omission rates in a sustained attention task. Further, the enhancement of effective connectivity by stimulation was correlated with improved behavioral performance. Our work demonstrates a potential circuit-level causal mechanism for how the higher-order visual thalamus modulates cortical communication through rhythmic synchronization during sustained attention.
Hemiancistrus platyrhynchus Fowler 1943
Creators: name: Ardila, Carlos
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Siluriformes
Loricariidae
Hemiancistrus
Hemiancistrus platyrhynchus

description: Hemiancistrus platyrhynchus:
ANSP-70512, Holotype, 70.7 mm SL, Colombia, Florencia, Orteguasa River basin, Brother Nicéforo María, 1931. ANSP-70513, Paratype, 67.75 mm SL, Colombia, Florencia, Orteguasa River basin, Brother Nicéforo María, 1931. MBUCV-V-18376 (ex. ANSP-84570), 3 ex., 37.4–56.1 mm SL, Colombia, Brother Nicéforo María, 1931.
description: Published as part of Ardila, Carlos, 2017, A new species of the catfish genus Cordylancistrus (Siluriformes, Loricariidae) from the Sierra Nevada de Santa Marta, Colombia, pp. 256-266 in Zootaxa 4329 (3) on page 265, DOI: 10.11646/zootaxa.4329.3.4, http://zenodo.org/record/1002500
Dugongidae Gray 1821
Creators: name: Russell A. Mittermeier
name: Don E. Wilson
Publisher: name: Lynx Edicions
Year: 2014
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Mammalia
Sirenia
Dugongidae

description: Family DUGONGIDAE
(DUGONG)
• Medium-sized sirenian with pectoral flippers lacking nails, no external hindlimbs, and a whale-like tail fluke with a median notch.
• 200-330 cm.
• Subtropical and tropical Indo-West Pacific waters.
Coastal and island waters with seagrass meadows
.
1 genus, 1 species, at least 1 extant taxon
.
1 species Vulnerable; 1 species Extinct since 1600 (1768).
description: Published as part of Russell A. Mittermeier & Don E. Wilson, 2014, Dugongidae, pp. 564-573 in Handbook of the Mammals of the World – Volume 4 Sea Mammals, Barcelona :Lynx Edicions on page 564, DOI: 10.5281/zenodo.6598667
Oncorhynchus gorbuscha
Creators: name: Love, Milton S.
name: Bizzarro, Joseph J.
name: Cornthwaite, Maria
name: Frable, Benjamin W.
name: Maslenikov, Katherine P.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Salmoniformes
Salmonidae
Oncorhynchus
Oncorhynchus gorbuscha

description: Oncorhynchus gorbuscha (Walbaum, 1792).
Humpback Salmon or Pink Salmon. To 76 cm (2.5 ft) TL (Hart 1973). Northern Siberia to western Canada; North Korea and Japan to Beaufort Sea coast of Alaska (Mecklenburg et al. 2002) and Canada (westwards to Sachs Harbor, Banks Island) (Stephenson 2006), and south to La Jolla, California; throughout North Pacific and Bering Sea north of about 40°N (Mecklenburg et al. 2002). Successfully introduced in upper Great Lakes, and rivers of Norway and Russia (Pietsch and Orr 2019). Depth: maximum to 74 m (243 ft) (Walker et al. 2007); based on a bottom trawl collection, perhaps to 118 m (387 ft) (NWFSC-FRAM). Anadromous.
description: Published as part of Love, Milton S., Bizzarro, Joseph J., Cornthwaite, Maria, Frable, Benjamin W. & Maslenikov, Katherine P., 2021, Checklist of marine and estuarine fishes from the Alaska-Yukon Border, Beaufort Sea, to Cabo San Lucas, Mexico, pp. 1-285 in Zootaxa 5053 (1) on page 53, DOI: 10.11646/zootaxa.5053.1.1, http://zenodo.org/record/5578008
Coregonus pidschian
Creators: name: Love, Milton S.
name: Bizzarro, Joseph J.
name: Cornthwaite, Maria
name: Frable, Benjamin W.
name: Maslenikov, Katherine P.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Salmoniformes
Salmonidae
Coregonus
Coregonus pidschian

description: Coregonus pidschian (Gmelin, 1789).
Humpback Whitefish. To 54 cm (31.5 in) TL. Along Arctic coasts from Siberia, Russia, west to Kara Sea, and eastward along Alaska and Canadian coasts to Hudson Bay and New England (as Clupea clupeaformis of Canadian authors). American biologists have generally referred to anadromous and Alaska-dwelling individuals of this species as “humpback” whitefish, Coregonus pidschian. Anadromous fish in northern Canada usually have been called “lake” whitefish (Coregonus clupeaformis (Mitchill, 1818)) by Canadian researchers. Following McDermid et al. (2007), we refer to the individuals residing from the Alaska Peninsula to the U.S. Chukchi and Beaufort Sea drainages and eastward at least to the lower Mackenzie River as this species. All in Love et al. (2016).
description: Published as part of Love, Milton S., Bizzarro, Joseph J., Cornthwaite, Maria, Frable, Benjamin W. & Maslenikov, Katherine P., 2021, Checklist of marine and estuarine fishes from the Alaska-Yukon Border, Beaufort Sea, to Cabo San Lucas, Mexico, pp. 1-285 in Zootaxa 5053 (1) on page 53, DOI: 10.11646/zootaxa.5053.1.1, http://zenodo.org/record/5578008
Leptoancistrus canensis
Creators: name: Ardila, Carlos
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Siluriformes
Loricariidae
Leptoancistrus
Leptoancistrus canensis

description: Leptoancistrus canensis:
MBUCV-V-28064 (ex. STRI-4851), 6 ex., 27.0– 37.9 mm SL, Panamá, Quebrada Bayano, aprox. 09°07’12”N 78°21’36”W, 14 February 1996.
description: Published as part of Ardila, Carlos, 2017, A new species of the catfish genus Cordylancistrus (Siluriformes, Loricariidae) from the Sierra Nevada de Santa Marta, Colombia, pp. 256-266 in Zootaxa 4329 (3) on page 265, DOI: 10.11646/zootaxa.4329.3.4, http://zenodo.org/record/1002500
Pseudancistrus atratoenesis
Creators: name: Ardila, Carlos
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Siluriformes
Loricariidae
Pseudancistrus
Pseudancistrus atratoenesis

description: Pseudancistrus atratoenesis:
ICNMHN-46, 7 Paratypes (5 Alc, 2 C&S), 42.81–75.50 mm SL, Colombia, Departmento de Antioquiá, Quebrada La Noche, tributary to upper Río Atrato, Rio Sucio, western Colombia, elevation about 550 meters. 10 August 1959.
description: Published as part of Ardila, Carlos, 2017, A new species of the catfish genus Cordylancistrus (Siluriformes, Loricariidae) from the Sierra Nevada de Santa Marta, Colombia, pp. 256-266 in Zootaxa 4329 (3) on page 265, DOI: 10.11646/zootaxa.4329.3.4, http://zenodo.org/record/1002500
Orcevia pakse Yu & Maddison & Zhang 2023, sp. nov.
Creators: name: Yu, Kun
name: Maddison, Wayne P.
name: Zhang, Junxia
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Salticidae
Orcevia
Orcevia pakse

description: Orcevia pakse Yu & Zhang, sp. nov. (巴DZĸ尔¤)
Figs 189–198, 277
Type material. Holotype: ♂ (MHBU-ARA-00023557), LAOS: Pakse, Tad Fane Waterfall, 20 November 2012, leg. F. Zhang, C. Zhang & Z. Gao. Paratype: 1♂ (MHBU-ARA-00023558), LAOS: Pakse, Tad E Tu Waterfall, 16 November 2012, leg. F. Zhang.
Etymology. The specific epithet is from the type locality; noun in apposition.
Diagnosis. The new species resembles O. deelemanae sp. nov. in the flat tip of RTA, but differs in the longer length of RTA and the smaller lobe-like protrusion of tegulum (Figs 193, 291).
Description. Male (holotype). Habitus as shown in Figs 189–190. Carapace length 2.52; abdomen length 2.20; measurements of eyes: AME 0.43, ALE 0.25, PME 0.08, PLE 0.27; measurements of legs: I 5.17 (1.52, 0.99, 1.26, 0.89, 0.51), II 3.53 (1.16, 0.62, 0.69, 0.64, 0.42), III 3.55 (1.24, 0.57, 0.70, 0.63, 0.41), IV 4.11 (1.33, 0.55, 0.93, 0.84, 0.46); leg formula 1432. Carapace dark, dorsal abdomen brown, ventral abdomen, and legs light except melanic area present on distal half of femora and tibiae of legs III–IV; cephalon covered by pale yellow setae, dorsal abdomen covered with pale setae dense marginally and relatively sparse centrally.
Palp (Figs 191–193): embolus slender, S-shaped in ventral view and without apophysis, basal part of embolus without grooves along extending direction of embolus; apophysis on embolic disc sharp; RTA rather long, bent basally, lobe on tip of RTA small and indistinct, tip of RTA relatively flat.
Female. Unknown.
Distribution. Laos (Pakse).
description: Published as part of Yu, Kun, Maddison, Wayne P. & Zhang, Junxia, 2023, Taxonomic revision of Orcevia Thorell, 1890, with description of fifteen new species (Araneae, Salticidae, Euophryini), pp. 1-79 in Zootaxa 5384 (1) on page 13, DOI: 10.11646/zootaxa.5384.1.1, http://zenodo.org/record/10376440
Pseudancistrus carnegiei Eigenmann 1916
Creators: name: Ardila, Carlos
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Siluriformes
Loricariidae
Pseudancistrus
Pseudancistrus carnegiei

description: Pseudancistrus carnegiei:
FMNH-58350, Holotype, 82.67 mm SL, Colombia, Santander, Río San Gil. FMNH- 58351, 2 of 5 Paratypes, 17.1–31.42 mm SL.
description: Published as part of Ardila, Carlos, 2017, A new species of the catfish genus Cordylancistrus (Siluriformes, Loricariidae) from the Sierra Nevada de Santa Marta, Colombia, pp. 256-266 in Zootaxa 4329 (3) on page 265, DOI: 10.11646/zootaxa.4329.3.4, http://zenodo.org/record/1002500
Orcevia proszynskii
Creators: name: Yu, Kun
name: Maddison, Wayne P.
name: Zhang, Junxia
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Salticidae
Orcevia
Orcevia proszynskii

description: Orcevia proszynskii (Song, Gu & Chen, 1988) (Ḃ氏ĸ尔¤)
Figs 19, 23, 199–217, 281
Laufeia proszynskii Song, Gu & Chen, 1988: 70, figs 1–2; Song, Zhu & Chen, 1999: 532, fig. 302K; Peng, 2020: 206, figs 140a–b.
Orcevia proszynskii (Song, Gu & Chen, 1988): Prószyński & Deeleman-Reinhold, 2012: 50; Prószyński, 2017: 75.
Material examined. 1♂ (Topotype; MHBU-ARA-00023614), CHINA: Hainan Island, Ledong County, Jianfengling National Park, Mingfenggu, 9 April 2016, leg. C. Jin & J. He; 1♂ 1♀ (MHBU-ARA-00023641~MHBU-ARA-00023642), CHINA: Hainan Island, Sanya City, Haishishanmeng Scenic Area, 18.2533°N, 109.5457°E, 369m elev., 23 July 2022, leg. W. Wang, HBUARA#2022-133.
Diagnosis. It can be distinguished from all other congeners by its straight spine-like RTA, domed top margin of LPT and the absence of VFB in males (Fig. 210), and the presence of rough central area which has a large number of small pits on sternum of females (Fig. 207).
Description. Male. See Song, Gu & Chen (1988).
Female. Habitus as shown in Fig. 204. Carapace length 2.92; abdomen length 3.15; measurements of eyes:AME 0.62, ALE 0.41, PME 0.12, PLE 0.33; measurements of legs: I 4.85 (1.57, 0.93, 1.04, 0.74, 0.57), II 4.44 (1.53, 0.87, 0.90, 0.66, 0.48), III 4.75 (1.54, 0.69, 0.97, 0.93, 0.62), IV 5.43 (1.75, 0.77, 1.26, 1.04, 0.61); leg formula 4132. Body rather dark, sternum with dense pits centrally; ventral surface of each trochanter flat.
Epigynum (Fig. 212): outer rim of each atrium extending upwards and connecting each other, forming a large but very shallow concave area at upper part of epigynum. Vulva (Fig. 213): accessory glands with many small branches distally.
Natural History. All specimens were collected from cracks of tree trunks or handrails (Figs 19, 23).
Distribution. China (Hainan).
description: Published as part of Yu, Kun, Maddison, Wayne P. & Zhang, Junxia, 2023, Taxonomic revision of Orcevia Thorell, 1890, with description of fifteen new species (Araneae, Salticidae, Euophryini), pp. 1-79 in Zootaxa 5384 (1) on pages 13-14, DOI: 10.11646/zootaxa.5384.1.1, http://zenodo.org/record/10376440
TEZKOR-QIDIRUV FAOLIYATIDA INSON HUQUQLARI, ERKINLIKLARI VA QONUNIY MANFAATLARINI TA'MINLASH TUSHUNCHASINING TAHLILI
Creators: name: Bobomurodov, Farxod
Publisher: name: Zenodo
Year: 2024

description: Maqolada tezkor-qidiruv faoliyatida inson huquqlari, erkinliklari va qonuniy manfaatlarini ta'minlash tushunchasi haqida fikr bildirgan mutaxassislarning fikrlari tahlil qilinib, "Tqfda inson huquqlari va erkinliklarining buzilishi", "Tqfda inson huquqlari va erkinliklariga rioya qilish", "Tqfda inson huquqlari va erkinliklarini ta'minlash" tushunchalariga mualliflik ta'rifi ishlab chiqilgan.
Oncorhynchus keta
Creators: name: Love, Milton S.
name: Bizzarro, Joseph J.
name: Cornthwaite, Maria
name: Frable, Benjamin W.
name: Maslenikov, Katherine P.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Salmoniformes
Salmonidae
Oncorhynchus
Oncorhynchus keta

description: Oncorhynchus keta (Walbaum, 1792).
Calico Salmon, Chum Salmon, or Dog Salmon. To 109 cm (42.9 in) TL (Salo in Groot and Margolis 1991). Arctic coasts of Siberia west to Laptev Sea and east across Alaskan and Canadian Arctic to Kugluktuk, Nunavut (Stephenson 2006); Korea and southern Japan to Beaufort Sea, Alaska to Del Mar, southern California near U.S. –Mexican border (Mecklenburg et al. 2002). Depth: at sea, surface to 253 m (830 ft) (Walker et al. 2007). Anadromous.
description: Published as part of Love, Milton S., Bizzarro, Joseph J., Cornthwaite, Maria, Frable, Benjamin W. & Maslenikov, Katherine P., 2021, Checklist of marine and estuarine fishes from the Alaska-Yukon Border, Beaufort Sea, to Cabo San Lucas, Mexico, pp. 1-285 in Zootaxa 5053 (1) on page 53, DOI: 10.11646/zootaxa.5053.1.1, http://zenodo.org/record/5578008
De-escalating and escalating treatments for early-stage breast cancer: the St. Gallen International Expert Consensus Conference on the Primary Therapy of Early Breast Cancer 2017
Creators: name: Viale, G.
name: Pagani, O.
name: Rutgers, E.J.T.
name: Huober, J.
name: Cardoso, F.
name: Toi, M.
name: Khaled, H.
name: Denkert, C.
name: Osborne, K.C.
name: Bergh, J.
name: Dubsky, P.
name: Gulluoglu, B.
name: Senn, H.-J.
name: Shao, Z.
name: Thürlimann, B.
name: Hayes, D.F.
name: Tutt, A.
name: Ro, J.
name: Galimberti, V.
name: Partridge, A.H.
name: Goodwin, P.
name: Francis, P.
name: Curigliano, G
name: Watanabe, T.
name: Huang, C.-S.
name: André, F.
name: Cuzick, J.
name: Burstein, H.J.
name: Regan, M.M.
name: Brucker, S.Y.
name: Piccart-Gebhart, M.
name: Pritchard, K.
name: Whelan, T.J.
name: Gnant, M.
name: Garber, J.
name: Ejlertsen, B.
name: Harbeck, N.
name: Orecchia, R.
name: Semiglazov, V.
name: Jiang, Z.
name: Baselga, J.
name: Colleoni, M.
name: Carey, L.
name: Xu, B.
name: Karlsson, P.
name: Winer, E.P.
name: Jassem, J.
name: Loibl, S.
name: Di Leo, A.
name: Bonnefoi, H.
name: Smith, I.
name: Ciruelos, E.
name: Sedlmayer, F.
name: Morrow, M.
Publisher: name: Elsevier
Year: 2017

description:
The 15th St. Gallen International Breast Cancer Conference 2017 in Vienna, Austria reviewed substantial new evidence on loco-regional and systemic therapies for early breast cancer. Treatments were assessed in light of their intensity, duration and side-effects, seeking where appropriate to escalate or de-escalate therapies based on likely benefits as predicted by tumor stage and tumor biology. The Panel favored several interventions that may reduce surgical morbidity, including acceptance of 2 mm margins for DCIS, the resection of residual cancer (but not baseline extent of cancer) in women undergoing neoadjuvant therapy, acceptance of sentinel node biopsy following neoadjuvant treatment of many patients, and the preference for neoadjuvant therapy in HER2 positive and triple-negative, stage II and III breast cancer. The Panel favored escalating radiation therapy with regional nodal irradiation in high-risk patients, while encouraging omission of boost in low-risk patients. The Panel endorsed gene expression signatures that permit avoidance of chemotherapy in many patients with ER positive breast cancer. For women with higher risk tumors, the Panel escalated recommendations for adjuvant endocrine treatment to include ovarian suppression in premenopausal women, and extended therapy for postmenopausal women. However, low-risk patients can avoid these treatments. Finally, the Panel recommended bisphosphonate use in postmenopausal women to prevent breast cancer recurrence. The Panel recognized that recommendations are not intended for all patients, but rather to address the clinical needs of the majority of common presentations. Individualization of adjuvant therapy means adjusting to the tumor characteristics, patient comorbidities and preferences, and managing constraints of treatment cost and access that may affect care in both the developed and developing world.
Pseudancistrus cobrensis
Creators: name: Ardila, Carlos
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Siluriformes
Loricariidae
Pseudancistrus
Pseudancistrus cobrensis

description: Pseudancistrus cobrensis:
MBUCV-V-18375 (ex. USNM- 121037), 10 Paratypes, 12.7–53.8 mm SL, Venezuela, Táchira State, Maracaibo Basin, Catatumbo River system, Cobre River, below La Grita, tributary to Quinta River, approx. 08°02’N 71°59’W, L.P. Schultz, 31 March 1942.
description: Published as part of Ardila, Carlos, 2017, A new species of the catfish genus Cordylancistrus (Siluriformes, Loricariidae) from the Sierra Nevada de Santa Marta, Colombia, pp. 256-266 in Zootaxa 4329 (3) on page 265, DOI: 10.11646/zootaxa.4329.3.4, http://zenodo.org/record/1002500
Oncorhynchus kisutch
Creators: name: Love, Milton S.
name: Bizzarro, Joseph J.
name: Cornthwaite, Maria
name: Frable, Benjamin W.
name: Maslenikov, Katherine P.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Salmoniformes
Salmonidae
Oncorhynchus
Oncorhynchus kisutch

description: Oncorhynchus kisutch (Walbaum, 1792).
Coho Salmon or Silver Salmon. To 108 cm (42.5 in) TL (Coad 1995). North Korea and Japan to Point Hope, Chukchi Sea, Alaska to Monterey Bay, central California (Mecklenburg et al. 2002), with strays to MacKenzie Delta, Northwest Territories (Stephenson 2006), to Bahía Camalu, northern Baja California (Messersmith 1965). Depth: surface to 97 m (318 m) (Walker et al. 2007). A much deeper record of 454 m (1,489 ft) (DFO) was recorded from a bottom longline survey; however, the fish could have been caught at a shallower depth as the hooks descended through the water column and a record from 421 m (1,381 ft) was from a bottom trawl (NWFSC-FRAM)
description: Published as part of Love, Milton S., Bizzarro, Joseph J., Cornthwaite, Maria, Frable, Benjamin W. & Maslenikov, Katherine P., 2021, Checklist of marine and estuarine fishes from the Alaska-Yukon Border, Beaufort Sea, to Cabo San Lucas, Mexico, pp. 1-285 in Zootaxa 5053 (1) on page 53, DOI: 10.11646/zootaxa.5053.1.1, http://zenodo.org/record/5578008
Pseudancistrus pediculatus Eigenmann 1918
Creators: name: Ardila, Carlos
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Siluriformes
Loricariidae
Pseudancistrus
Pseudancistrus pediculatus

description: Pseudancistrus pediculatus:
FMNH-58352, Holotype, 84.10 mm SL, Colombia, Villavicencio, Río Negro. FMNH-58564, 2 of 3 Paratypes, 34.46–63.12 mm SL. FMNH-58565, 2 of 4 Paratypes, 32.04–69.9 mm SL.
description: Published as part of Ardila, Carlos, 2017, A new species of the catfish genus Cordylancistrus (Siluriformes, Loricariidae) from the Sierra Nevada de Santa Marta, Colombia, pp. 256-266 in Zootaxa 4329 (3) on page 265, DOI: 10.11646/zootaxa.4329.3.4, http://zenodo.org/record/1002500
Oncorhynchus nerka
Creators: name: Love, Milton S.
name: Bizzarro, Joseph J.
name: Cornthwaite, Maria
name: Frable, Benjamin W.
name: Maslenikov, Katherine P.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Salmoniformes
Salmonidae
Oncorhynchus
Oncorhynchus nerka

description: Oncorhynchus nerka (Walbaum, 1792).
Blueback, Red Salmon, or Sockeye Salmon. To 84 cm (33.1 in) TL (Coad 1995). Northern Japan and Sea of Okhotsk to Point Hope, Chukchi Sea, Alaska to Malibu Point, southern California (Personal communication: Scripps Institution of Oceanography Fish Collection, La Jolla, California) with strays along Arctic Alaska and Canada coasts to Bathurst Inlet (Craig and Haldorson 1986) and northward to Sachs Harbour, Banks Island (Stephenson 2006); across Pacific Ocean north of about 40°N. Depth: surface to 83 m (272 ft) (Walker et al. 2007). Anadromous and freshwater populations. Range of the nonanadromous (freshwater) form, called Kokanee, not included here.
description: Published as part of Love, Milton S., Bizzarro, Joseph J., Cornthwaite, Maria, Frable, Benjamin W. & Maslenikov, Katherine P., 2021, Checklist of marine and estuarine fishes from the Alaska-Yukon Border, Beaufort Sea, to Cabo San Lucas, Mexico, pp. 1-285 in Zootaxa 5053 (1) on page 53, DOI: 10.11646/zootaxa.5053.1.1, http://zenodo.org/record/5578008
RASAL2 Confers Collateral MEK/EGFR Dependency in Chemoresistant Triple-Negative Breast Cancer
Creators: name: Saladi, Srinivas Vinod
name: Melkonjan, Nsan
name: Mayer, Erica L.
name: Schultz, Andrew
name: Carey, Lisa A.
name: Liu, Minetta C.
name: Koh, Siang-Boon
name: Traina, Tiffany A.
name: Rugo, Hope S.
name: Stearns, Vered
name: Ellisen, Leif W.
name: Lawrence, Michael S.
name: Isakoff, Steven J.
name: Matissek, Karina J.
name: Langenbucher, Adam
name: Ross, Kenneth
name: Ramaswamy, Sridhar
name: He, Lei
Publisher: name: American Association for Cancer Research (AACR)
Year: 2021

description:
PURPOSE: While chemotherapy remains the standard treatment for triple-negative breast cancer (TNBC), identifying and managing chemoresistant tumors has proven elusive. We sought to discover hallmarks and therapeutically actionable features of refractory TNBC through molecular analysis of primary chemoresistant TNBC specimens. EXPERIMENTAL DESIGN: We performed transcriptional profiling of tumors from a phase II clinical trial of platinum chemotherapy for advanced TNBC (TBCRC-009), revealing a gene expression signature that identified de novo chemorefractory tumors. We then employed pharmacogenomic data mining, proteomic and other molecular studies to define the therapeutic vulnerabilities of these tumors. RESULTS: We reveal the RAS-GTPase-activating protein (RAS-GAP) RASAL2 as an upregulated factor that mediates chemotherapy resistance but also an exquisite collateral sensitivity to combination MAP kinase kinase (MEK1/2) and EGFR inhibitors in TNBC. Mechanistically, RASAL2 GAP activity is required to confer kinase inhibitor sensitivity, as RASAL2-high TNBCs sustain basal RAS activity through suppression of negative feedback regulators SPRY1/2, together with EGFR upregulation. Consequently, RASAL2 expression results in failed feedback compensation upon co-inhibition of MEK1/2 and EGFR that induces synergistic apoptosis in vitro and in vivo. In patients with TNBC, high RASAL2 levels predict clinical chemotherapy response and long-term outcomes, and are associated via direct transcriptional regulation with activated oncogenic Yes-Associated Protein (YAP). Accordingly, chemorefractory patient-derived TNBC models exhibit YAP activation, high RASAL2 expression, and tumor regression in response to MEK/EGFR inhibitor combinations despite well-tolerated intermittent dosing. CONCLUSIONS: These findings identify RASAL2 as a mediator of TNBC chemoresistance that rewires MAPK feedback and cross-talk to confer profound collateral sensitivity to combination MEK1/2 and EGFR inhibitors.
Pseudancistrus torbesensis
Creators: name: Ardila, Carlos
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Siluriformes
Loricariidae
Pseudancistrus
Pseudancistrus torbesensis

description: Pseudancistrus torbesensis:
MBUCV-V-18374 (ex. USNM- 121002), 5 Paratypes, 23.8–51.8 mm SL, Venezuela, Táchira State, Orinoco Basin, Apure River system, Torbes River, 1 kilometer above Táriba, tributary to Uribante River, approx. 07°50’N 72°20’W, L.P. Schultz, 31 March 1942.
description: Published as part of Ardila, Carlos, 2017, A new species of the catfish genus Cordylancistrus (Siluriformes, Loricariidae) from the Sierra Nevada de Santa Marta, Colombia, pp. 256-266 in Zootaxa 4329 (3) on page 265, DOI: 10.11646/zootaxa.4329.3.4, http://zenodo.org/record/1002500
Orcevia sokoli Yu & Maddison & Zhang 2023, comb. nov.
Creators: name: Yu, Kun
name: Maddison, Wayne P.
name: Zhang, Junxia
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Salticidae
Orcevia
Orcevia sokoli

description: Orcevia sokoli (Prószyński & Deeleman-Reinhold, 2013) comb. nov. (Ḱ氏ĸ尔¤)
Figs 250–258
Echeclus sokoli Prószyński & Deeleman-Reinhold, 2013: 124, figs 25–31; Prószyński, 2017: 80, fig. 34A.
Material examined. 2♀ (UBCZ; KYU-SAL739), MALAYSIA: Sarawak, Lambir Hills Nat. Pk., Pantu Trail, 4.2020– 4.2021°N, 114.0425– 114.0429°E, 110 m elev., 31 March 2012, leg. W.P. Maddison, E.K. Piascik, WPM#12- 105.
Diagnosis. Males can be distinguished from O. zabkai sp. nov. by the distally bicuspid RTA (Fig. 255; vs. RTA is unbranched in O. zabkai sp. nov.) and the wide embolus (Fig. 254; vs. narrower and longer in O. zabkai sp. nov.), females can be distinguished from O. zabkai sp. nov. by the starting part of copulatory duct separated from spermathecae, curved and formed an angle of ca. 80° (Fig. 258; vs. CD almost fused to spermathecae in O. zabkai sp. nov.).
Description. See Prószyński & Deeleman-Reinhold (2013).
Distribution. Malaysia (Sarawak).
Remark. The tubular accessory glands, the folded inner tubes in spermathecae and lobe-like protrusion of tegulum all indicate that this species belongs to Orcevia. Therefore, we herein propose this new combination.
description: Published as part of Yu, Kun, Maddison, Wayne P. & Zhang, Junxia, 2023, Taxonomic revision of Orcevia Thorell, 1890, with description of fifteen new species (Araneae, Salticidae, Euophryini), pp. 1-79 in Zootaxa 5384 (1) on page 15, DOI: 10.11646/zootaxa.5384.1.1, http://zenodo.org/record/10376440
Quantum dichotomies and coherent thermodynamics beyond first-order asymptotics
Creators: name: Lipka-Bartosik, Patryk
name: Chubb, Christopher T.
name: Renes, Joseph M.
name: Tomamichel, Marco
name: Korzekwa, Kamil
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: Information Theory (cs.IT)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences
subject: FOS: Computer and information sciences

description: We address the problem of exact and approximate transformation of quantum dichotomies in the asymptotic regime, i.e., the existence of a quantum channel $\mathcal E$ mapping $ρ_1^{\otimes n}$ into $ρ_2^{\otimes R_nn}$ with an error $ε_n$ (measured by trace distance) and $σ_1^{\otimes n}$ into $σ_2^{\otimes R_n n}$ exactly, for a large number $n$. We derive second-order asymptotic expressions for the optimal transformation rate $R_n$ in the small, moderate, and large deviation error regimes, as well as the zero-error regime, for an arbitrary pair $(ρ_1,σ_1)$ of initial states and a commuting pair $(ρ_2,σ_2)$ of final states. We also prove that for $σ_1$ and $σ_2$ given by thermal Gibbs states, the derived optimal transformation rates in the first three regimes can be attained by thermal operations. This allows us, for the first time, to study the second-order asymptotics of thermodynamic state interconversion with fully general initial states that may have coherence between different energy eigenspaces. Thus, we discuss the optimal performance of thermodynamic protocols with coherent inputs and describe three novel resonance phenomena allowing one to significantly reduce transformation errors induced by finite-size effects. What is more, our result on quantum dichotomies can also be used to obtain, up to second-order asymptotic terms, optimal conversion rates between pure bipartite entangled states under local operations and classical communication.
description: 53 pages, 6 figures, comments welcome
A short proof of the Hanlon-Hicks-Lazarev Theorem
Creators: name: Brown, Michael K.
name: Erman, Daniel
Publisher: name: arXiv
Year: 2023
Subjects: subject: Algebraic Geometry (math.AG)
subject: Commutative Algebra (math.AC)
subject: FOS: Mathematics
subject: 13D02, 14F08, 14M25

description: We give a short, new proof of a recent result of Hanlon-Hicks-Lazarev about toric varieties. As in their work, this leads to a proof of a conjecture of Berkesch-Erman-Smith on virtual resolutions and to a resolution of the diagonal in the simplicial case.
description: 6 pages. To appear in Forum of Mathematics, Sigma
Oncorhynchus mykiss
Creators: name: Love, Milton S.
name: Bizzarro, Joseph J.
name: Cornthwaite, Maria
name: Frable, Benjamin W.
name: Maslenikov, Katherine P.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Salmoniformes
Salmonidae
Oncorhynchus
Oncorhynchus mykiss

description: Oncorhynchus mykiss (Walbaum, 1792).
Rainbow Trout or Steelhead. To 122 cm (48 in) TL (Coad 1995). Pacific off Kuril Islands (Kovalenko et al. 2005), Sea of Okhotsk, and Kamchatka to Kuskokwim Bay and Port Moller, south-eastern Bering Sea to northern Baja California near Cuidad Durango (Morrow 1980). Anadromous and freshwater populations. The anadromous form is typically called Steelhead, while freshwater populations are called Rainbow Trout. Parasalmo is used by many European authors. Recently as Salmo gairdnerii (Richardson, 1836).
description: Published as part of Love, Milton S., Bizzarro, Joseph J., Cornthwaite, Maria, Frable, Benjamin W. & Maslenikov, Katherine P., 2021, Checklist of marine and estuarine fishes from the Alaska-Yukon Border, Beaufort Sea, to Cabo San Lucas, Mexico, pp. 1-285 in Zootaxa 5053 (1) on page 53, DOI: 10.11646/zootaxa.5053.1.1, http://zenodo.org/record/5578008
Pagurus forceps H. Milne Edwards 1836
Creators: name: Mantelatto, Fernando Luis
name: Pardo, Luis Miguel
name: Pileggi, Leonardo Gomes
name: Felder, Darryl L.
Publisher: name: Zenodo
Year: 2009
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda
Paguridae
Pagurus
Pagurus forceps

description: Pagurus forceps H. Milne Edwards, 1836
Type locality: shores of Chile, probably Valparaíso (see Haig 1955 and Forest & Saint Laurent, 1968 for review).
Material examined: 3 males (3.20, 3.41, 4.36* mm Shield Length = SL), 2 females (3.28, 3.48 mm SL), Coquimbo, Chile, October 2007, CCDB 2078 (DNA voucher); 2 males (4.36, 4.41 mm SL), 1 female (4.23 mm SL), 1 ovigerous female (2.95 mm SL), Punta de Tralca, Central Chile, February 2005, CCDB 2079; 1 male (3.89 mm SL), 1 female (3.99 mm SL), Punta de Tralca, Central Chile, July 2004, CCDB 1806 (DNA voucher); 2 males (3.59, 4.76 mm SL), 1 ovigerous female (3.32 mm SL), Punta de Tralca, Central Chile, July 2004, CCDB 1750 (*underline shield lengths indicates the specimens used for molecular analysis from numbered lot and here considered as DNA voucher).
description: Published as part of Mantelatto, Fernando Luis, Pardo, Luis Miguel, Pileggi, Leonardo Gomes & Felder, Darryl L., 2009, Taxonomic re-examination of the hermit crab species Pagurus forceps and Pagurus comptus (Decapoda: Paguridae) by molecular analysis, pp. 20-32 in Zootaxa 2133 on page 25, DOI: 10.5281/zenodo.188438
Alliance A011801 (compassHER2 RD): postneoadjuvant T-DM1 + tucatinib/placebo in patients with residual HER2-positive invasive breast cancer
Creators: name: Symmans, William Fraser
name: Goetz, Matthew P
name: Borges, Virginia F
name: Weiss, Anna
name: Irvin, William J
name: Tung, Nadine M
name: Kommalapati, Anuhya
name: Ballman, Karla V
name: McCall, Linda
name: Blinder, Victoria
name: Krop, Ian
name: Lee, Myounghee
name: Mitchell, Melissa
name: Zemla, Tyler
name: O'Sullivan, Ciara C
name: Partridge, Ann H
name: Carey, Lisa A
Publisher: name: Taylor & Francis
Year: 2021

description:
This report describes the rationale, purpose and design of A011801 (CompassHER2 RD), an ongoing prospective, multicenter, Phase III randomized trial. Eligible patients in the United States (US) and Canada with high-risk (defined as ER-negative and/or node-positive) HER2-positive (HER2+) residual disease (RD) after a predefined course of neoadjuvant chemotherapy and HER2-directed treatment are randomized 1:1 to adjuvant T-DM1 and placebo, versus T-DM1 and tucatinib. Patients have also received adjuvant radiotherapy and/or endocrine therapy, if indicated per standard of care guidelines. The primary objective of the trial is to determine if the invasive disease-free survival (iDFS) with T-DM1 plus tucatinib is superior to iDFS with T-DM1 plus placebo; other outcomes of interest include overall survival (OS), breast cancer-free survival (BCFS), distant recurrence-free survival (DRFS), brain metastases-free survival (BMFS) and disease-free survival (DFS). Correlative biomarker, quality of life (QoL) and pharmacokinetic (PK) end points are also evaluated.
Oncorhynchus tshawytscha
Creators: name: Love, Milton S.
name: Bizzarro, Joseph J.
name: Cornthwaite, Maria
name: Frable, Benjamin W.
name: Maslenikov, Katherine P.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Salmoniformes
Salmonidae
Oncorhynchus
Oncorhynchus tshawytscha

description: Oncorhynchus tshawytscha (Walbaum, 1792).
Chinook Salmon or King Salmon. To 160 cm (63 in) TL (Coad 1995). Northern Japan to Point Hope, Chukchi Sea, Alaska, with strays across northern Alaska to Coppermine River in Canada (Morrow 1980), to central Baja California at Bahía de Sebastian Vizcaino (27°54’N, 114°17’W) (De La Cruz-Agüero 1999). Depth: at sea, surface to 538 m (1,765 ft) (Courtney et al. 2019). Anadromous.
description: Published as part of Love, Milton S., Bizzarro, Joseph J., Cornthwaite, Maria, Frable, Benjamin W. & Maslenikov, Katherine P., 2021, Checklist of marine and estuarine fishes from the Alaska-Yukon Border, Beaufort Sea, to Cabo San Lucas, Mexico, pp. 1-285 in Zootaxa 5053 (1) on page 54, DOI: 10.11646/zootaxa.5053.1.1, http://zenodo.org/record/5578008
Pagurus comptus White 1847
Creators: name: Mantelatto, Fernando Luis
name: Pardo, Luis Miguel
name: Pileggi, Leonardo Gomes
name: Felder, Darryl L.
Publisher: name: Zenodo
Year: 2009
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Decapoda
Paguridae
Pagurus
Pagurus comptus

description: Pagurus comptus White, 1847
Type locality: Falkland Islands (see Haig 1955 and Forest & Saint Laurent, 1968 for review). Material examined: 2 males (6.26, 8.82 mm Shield Length), 2 ovigerous females (3.59, 4.38 mm SL), Bahía Gente Grande, Patagonia, Chile, July 2004, CCDB 1751 (DNA Voucher); 3 males (3.71, 4.24, 4.60 mm SL), Puerto del Hambre, Punta Arenas, Chile, June 2004, CCDB 1805 (DNA Voucher); 2 males (5.00, 5.28 mm SL), 2 ovigerous females (4.10, 4.25 mm SL), Punta Cavendish, Puerto Deseado, Patagonia, Argentina, July 2005, CCDB 1702 (DNA Voucher); 3 males (3.11, 5.77, 6.26 mm SL), Patagonia, Argentina, October 2007, CCDB 2196 (DNA Voucher); 1 male (6.00 mm SL), Patagonia, Argentina, June 2008, CCDB 2462.
description: Published as part of Mantelatto, Fernando Luis, Pardo, Luis Miguel, Pileggi, Leonardo Gomes & Felder, Darryl L., 2009, Taxonomic re-examination of the hermit crab species Pagurus forceps and Pagurus comptus (Decapoda: Paguridae) by molecular analysis, pp. 20-32 in Zootaxa 2133 on page 25, DOI: 10.5281/zenodo.188438
Evaluation of a Liquid Biopsy-Breast Cancer Methylation (LBx-BCM) Cartridge Assay for Predicting Early Disease Progression and Survival: TBCRC 005 Prospective Trial.
Creators: name: Campbell, Scott
name: Nanda, Rita
name: Cope, Leslie
name: Marla, Sudhakar
name: Tulac, Suzana
name: Fackler, Mary Jo
name: Carey, Lisa A
name: Sukumar, Saraswati
name: Venkatesan, Neesha
name: Storniolo, Anna Maria
name: Wolff, Antonio C
name: Bates, Michael
name: Forero-Torres, Andres
name: Visvanathan, Kala
name: Considine, Michael
name: Lin, Nancy U
name: Umbricht, Christopher B
name: Wu, Natalie C
name: Sokoll, Lori
name: Ingle, James N
Publisher: name: American Association for Cancer Research (AACR)
Year: 2022

description:
PURPOSE: We previously demonstrated that high levels of circulating methylated DNA are associated with subsequent disease progression in women with metastatic breast cancer (MBC). In this study, we evaluated the clinical utility of a novel liquid biopsy-breast cancer methylation (LBx-BCM) prototype assay using the GeneXpert cartridge system for early assessment of disease progression in MBC. EXPERIMENTAL DESIGN: The 9-marker LBx-BCM prototype assay was evaluated in TBCRC 005, a prospective biomarker study, using plasma collected at baseline, week 4, and week 8 from 144 patients with MBC. RESULTS: At week 4, patients with MBC with high cumulative methylation (CM) had a significantly shorter median PFS (2.88 months vs. 6.60 months, P = 0.001) and OS (14.52 months vs. 22.44 months, P = 0.005) compared with those with low CM. In a multivariable model, high versus low CM was also associated with shorter PFS (HR, 1.90; 95% CI, 1.20-3.01; P = 0.006). Change in CM from baseline to week 4 (OR, 4.60; 95% CI, 1.77-11.93; P = 0.002) and high levels of CM at week 4 (OR, 2.78; 95% CI, 1.29-5.99; P = 0.009) were associated with progressive disease at the time of first restaging. A robust risk model based on week 4 circulating CM levels was developed to predict disease progression as early as 3 months after initiating a new treatment. CONCLUSIONS: The automated LBx-BCM prototype assay is a promising clinical tool for detecting disease progression a month after initiating treatment in women with MBC undergoing routine care. The next step is to validate its clinical utility for specific treatments.
Sealing the heart from the inside out
Creators: name: Cheng, Ke
name: Huang, Ke
Publisher: name: Springer Nature
Year: 2022

description:
Myocardial infarction (MI) can occur after severe atherosclerosis or
when a clot stops blood flow in a coronary artery. Patients with acute
MI typically receive emergency percutaneous coronary intervention to
recanalize the blocked vasculature. However, fresh oxygenized arterial
blood will strike the heart again during reperfusion, causing extensive
secondary damage and inflammation. Because the adult human heart
has a fairly limited regenerative capability, a large scar caused by a
heart attack cannot spontaneously heal, and may lead to heart failure.
The Phase II MutHER Study of Neratinib Alone and in Combination with Fulvestrant in HER2-Mutated, Non-amplified Metastatic Breast CancerNeratinib and Fulvestrant in HER2-Mutated Breast Cancer
Creators: name: Gao, Feng
name: Pegram, Mark D.
name: Ellis, Matthew J.
name: Haas, Brittney
name: Thomas, Shana
name: Lin, Nancy U.
name: Luo, Jingqin
name: Pluard, Timothy J.
name: Valdez-Albini, Frances
name: Jones, Jason M.
name: Cobleigh, Melody
name: Anderson, Jill
name: Marcom, P. Kelly
name: Lu, Janice
name: Winer, Eric P.
name: Freedman, Rachel A.
name: Bucheit, Leslie
name: Bose, Ron
name: Bryce, Richard
name: Goetz, Matthew P.
name: Nangia, Julie R.
name: Ma, Cynthia X.
name: Kimmick, Gretchen
name: Carey, Lisa A.
name: Lalani, Alshad S.
Publisher: name: American Association for Cancer Research (AACR)
Year: 2022

description:
PURPOSE: HER2 mutations (HER2mut) induce endocrine resistance in estrogen receptor-positive (ER+) breast cancer. PATIENTS AND METHODS: In this single-arm multi-cohort phase II trial, we evaluated the efficacy of neratinib plus fulvestrant in patients with ER+/HER2mut, HER2 non-amplified metastatic breast cancer (MBC) in the fulvestrant-treated (n = 24) or fulvestrant-naïve cohort (n = 11). Patients with ER-negative (ER-)/HER2mut MBC received neratinib monotherapy in an exploratory ER- cohort (n = 5). RESULTS: The clinical benefit rate [CBR (95% confidence interval)] was 38% (18%-62%), 30% (7%-65%), and 25% (1%-81%) in the fulvestrant-treated, fulvestrant-naïve, and ER- cohorts, respectively. Adding trastuzumab at progression in 5 patients resulted in three partial responses and one stable disease ≥24 weeks. CBR appeared positively associated with lobular histology and negatively associated with HER2 L755 alterations. Acquired HER2mut were detected in 5 of 23 patients at progression. CONCLUSIONS: Neratinib and fulvestrant are active for ER+/HER2mut MBC. Our data support further evaluation of dual HER2 blockade for the treatment of HER2mut MBC.
Prosopium cylindraceum
Creators: name: Love, Milton S.
name: Bizzarro, Joseph J.
name: Cornthwaite, Maria
name: Frable, Benjamin W.
name: Maslenikov, Katherine P.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Salmoniformes
Salmonidae
Prosopium
Prosopium cylindraceum

description: Prosopium cylindraceum (Pennant, 1784).
Round Whitefish. 56 cm (22 in) TL (Mecklenburg et al. 2002). In Asia, west to Yenisei River and southward to Kamchatka; throughout Alaska and British Columbia eastward across arctic Canada and southward to Connecticut (Mecklenburg et al. 2002). Some populations are anadromous and enter brackish waters of river deltas and estuaries (Reist in Coad and Reist 2018).
description: Published as part of Love, Milton S., Bizzarro, Joseph J., Cornthwaite, Maria, Frable, Benjamin W. & Maslenikov, Katherine P., 2021, Checklist of marine and estuarine fishes from the Alaska-Yukon Border, Beaufort Sea, to Cabo San Lucas, Mexico, pp. 1-285 in Zootaxa 5053 (1) on page 54, DOI: 10.11646/zootaxa.5053.1.1, http://zenodo.org/record/5578008