cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Spatiotemporal clustering, climate periodicity, and social-ecological risk factors for dengue during an outbreak in Machala, Ecuador, in 2010
Creators: name: Stewart-Ibarra, Anna
name: Muñoz, Ángel
name: Ryan, Sadie
name: Ayala, Efraín
name: Borbor-Cordova, Mercy
name: Finkelstein, Julia
name: Mejía, Raúl
name: Ordoñez, Tania
name: Recalde-Coronel, G.
name: Rivero, Keytia
Publisher: name: Columbia University
Year: 2014
Subjects: Pathology
Environmental sciences

description: Background: Dengue fever, a mosquito-borne viral disease, is a rapidly emerging public health problem in Ecuador and throughout the tropics. However, we have a limited understanding of the disease transmission dynamics in these regions. Previous studies in southern coastal Ecuador have demonstrated the potential to develop a dengue early warning system (EWS) that incorporates climate and non-climate information. The objective of this study was to characterize the spatiotemporal dynamics and climatic and social-ecological risk factors associated with the largest dengue epidemic to date in Machala, Ecuador, to inform the development of a dengue EWS. Methods: The following data from Machala were included in analyses: neighborhood-level georeferenced dengue cases, national census data, and entomological surveillance data from 2010; and time series of weekly dengue cases (aggregated to the city-level) and meteorological data from 2003 to 2012. We applied LISA and Moran’s I to analyze the spatial distribution of the 2010 dengue cases, and developed multivariate logistic regression models through a multi-model selection process to identify census variables and entomological covariates associated with the presence of dengue at the neighborhood level. Using data aggregated at the city-level, we conducted a time-series (wavelet) analysis of weekly climate and dengue incidence (2003-2012) to identify significant time periods (e.g., annual, biannual) when climate co-varied with dengue, and to describe the climate conditions associated with the 2010 outbreak. Results: We found significant hotspots of dengue transmission near the center of Machala. The best-fit model to predict the presence of dengue included older age and female gender of the head of the household, greater access to piped water in the home, poor housing condition, and less distance to the central hospital. Wavelet analyses revealed that dengue transmission co-varied with rainfall and minimum temperature at annual and biannual cycles, and we found that anomalously high rainfall and temperatures were associated with the 2010 outbreak. Conclusions: Our findings highlight the importance of geospatial information in dengue surveillance and the potential to develop a climate-driven spatiotemporal prediction model to inform disease prevention and control interventions. This study provides an operational methodological framework that can be applied to understand the drivers of local dengue risk.
title: R/V NATSUSHIMA Cruise report NT07-10
Creators: name: Jinbo, Mitsuru
Publisher: name: JAMSTEC
Year: 2007
Subjects: subject: Cruise report
subject: R/V NATSUSHIMA
subject: oceans

description: [CRUISE REPORT] This document is a preliminary report of NT07-10 on R/V NATSUSHIMA from 2007-06-09 to 2007-06-12.
EM VEZ DOS "ELEMENTOS"
Creators: name: Immig, Kai
Publisher: name: POLISSEMA – Revista de Letras do ISCAP
Year: 2019

description: O artigo pode ser lido como uma pequena introdução à linguística funcionalista martinetiana. Consiste numa breve apresentação comentada de alguns dos conceitos fundamentais (monema, dupla articulação, relação funcional, valor axiológico) da obra “Elementos de Linguística Geral“ aplicada, nas suas exemplificações, à língua alemã. Consideramos a abordagem de André Martinet digna de ser conhecida por todos os estudantes e interessados da linguística. Descreve e explica, de forma não-dogmática e simples, o funcionamento de um sistema linguístico, isto é, de uma língua humana (no original, da língua francesa), facilita o entendimento da dinâmica desse mesmo sistema e abre caminho para abordagens científicas (operação com elementos discretos, segmentação, comutação), também ao nível da significação.
description: POLISSEMA – Revista de Letras do ISCAP, No. 5 (2005)
title: CRUISE REPORT R/V Natsushima Cruise NT0707
Creators: name: Ishizuka, Osamu
Publisher: name: JAMSTEC
Year: 2007
Subjects: subject: Cruise report
subject: R/V NATSUSHIMA
subject: oceans

description: [CRUISE REPORT] This document is a preliminary report of NT07-07 on R/V NATSUSHIMA from 2007-04-17 to 2007-05-09.
Complete Response to Pembrolizumab in a Patient with Lynch Syndrome A Case Report
Creators: name: ALakkad, Ashraf
Publisher: name: figshare
Year: 2022
Subjects: Other health sciences not elsewhere classified

description: Background: Lynch syndrome LS is a life-threatening condition caused by heterozygous mutations in mismatch repair genes (MMR). People with this syndrome are at increased risk of developing different types of cancers, such as colorectal carcinomas, endometrial cancer, and ovarian cancers. Case report: The present case report discusses the case of a 36-year-old non-diabetic non- alcoholic female who came to the oncology department with a known history of Lynch syndrome. The patient had a significant past medical history. In 2003, she was diagnosed with left colon cancer for which she had left hemicolectomy followed by adjuvant chemotherapy. In 2004, she developed duodenal cancer for which she had Whipple surgery. Then, she developed ovarian cancer on both sides, which was also treated by surgery and adjuvant chemotherapy. After that, she developed uterine cancer, treated by surgery and adjuvant chemotherapy. The patient had a total colectomy and she underwent two ileostomy procedures. In 2014, immunohistochemistry testing confirmed the diagnosis that she was suffering from Lynch syndrome. Additionally, cancer sequencing panel testing in 2016 and MSH testing in 2018 further confirmed the diagnosis of Lynch syndrome as only the loss of nuclear expression of the PMS2 gene was revealed. Then in 2018, she developed a peritoneal metastasis of ovarian origin. This was the first time she started Pembrolizumab immunotherapy, that was finished at the end of 2019. One intriguing fact is that all her diseases cleared up and she continues to live normal life four years after stopping immunotherapy and she is in complete remission. Also, all her tumor markers have dropped down and normalized. Conclusion: Carrying the PMS2 germline mutation confers an extraordinarily high risk of developing LS-associated cancers. To decrease the morbidity and mortality associated with LS- related cancers, intensive clinical monitoring, pembrolizumab therapy, and preventive surgeries are strongly advised.
Εργασιακή παρενόχληση και τοξική ηγεσία
Creators: name: Γκιντώνης, Απόστολος
Publisher: name: Πανεπιστήμιο Πειραιώς
Year: 2023
Subjects: subject: Τοξική ηγεσία
subject: Εργασιακή παρενόχληση
subject: Εργασιακός εκφοβισμός

description: Η τοξική ηγεσία με την πάροδο των χρόνων τείνει να γίνει ένα σύνηθες φαινόμενο στους οργανισμούς και στις επιχειρήσεις, πράγμα το οποίο έχει δυσμενείς επιπτώσεις τόσο στις ίδιες όσο και στα μέλη που τις αποτελούν, δηλαδή τους εργαζόμενους της κατά κύριο λόγο. Από την άλλη πλευρά το φαινόμενο της εργασιακής παρενόχλησης ή αλλιώς του εργασιακού εκφοβισμού όπως επίσης λέγεται, δυστυχώς χρόνο με το χρόνο αντί να περιορίζεται, θα λέγαμε ότι αυξάνεται με επίσης αρνητικές συνέπειες στα θύματά της. Η παρούσα εργασία μελετάει τη σχέση μεταξύ τοξικής ηγεσίας και εργασιακής παρενόχλησης. Τα δεδομένα της έρευνάς μας συλλέχθηκαν μέσω ερωτηματολογίου, στο οποίο απάντησαν 288 εργαζόμενοι σε διάφορους τομείς του δημόσιου ή ιδιωτικού τομέα. Οι ερωτήσεις αφορούσαν τόσο τα δημογραφικά στοιχεία των συμμετεχόντων, όσο και τη μέτρηση των δύο εξεταζόμενων μεταβλητών της μελέτης, της τοξικής ηγεσίας και της εργασιακής παρενόχλησης. Από τα αποτελέσματα προέκυψε ισχυρή θετική συσχέτιση ανάμεσα στην τοξική ηγεσία και την εργασιακή παρενόχληση, χωρίς να διαδραματίζει ιδιαίτερο ρόλο το φύλο, η ηλικία, η οικογενειακή κατάσταση και το εκπαιδευτικό επίπεδο των ερωτηθέντων. Επομένως, η τοξική ηγεσία οδηγεί σε πολλές περιπτώσεις σε φαινόμενα εργασιακής παρενόχλησης και εκφοβισμού.
title: R/V NATSUSHIMA Cruise report NT07-06
Creators: name: Goto, Tadanori
Publisher: name: JAMSTEC
Year: 2007
Subjects: subject: Cruise report
subject: R/V NATSUSHIMA
subject: oceans

description: [CRUISE REPORT] This document is a preliminary report of NT07-06 on R/V NATSUSHIMA from 2007-04-02 to 2007-04-16.
Lessons from Africa: developing a global human rights framework for tuberculosis control and prevention
Creators: name: Slagle, Tracy
name: Ben Youssef, Mehdi
name: Calonge, Golda
name: Ben Amor, Yanis
Publisher: name: Columbia University
Year: 2014
Subjects: subject: Public health
subject: Law
subject: FOS: Law

description: Background: Tuberculosis is a highly contagious disease, and there has been a rise in recent years of drug-resistant cases no longer responding to standard treatment. In order to address this threat and contain possible transmission of drug-resistant cases, some countries have taken strong action, including the compulsory detention of non-adherent drug-resistant patients. These measures have been strongly criticized by human rights advocates, and they raise the question of how to legally protect both citizens and the community. Discussion: Following discussions with National Tuberculosis Programs in Africa (the continent with the highest incidence rates of tuberculosis worldwide), we show that of all the countries surveyed, all but one (Swaziland) had either no specific policy addressing tuberculosis, or only general policies regarding public health applicable to tuberculosis. Six countries also reported having policies that address non-adherence to treatment with containment (isolation in health facilities or incarceration), but laws are not adequately enforced. If the international community wants to effectively respond to the threat of tuberculosis transmission, there is a need to go beyond national tuberculosis policies and to implement an international framework for tuberculosis control, inspired by the Framework Convention on Tobacco Control, a key model for future public health treaties that address global burdens of disease. The framework, for which we clarify the conditions and procedures in this piece, would define the rights and responsibilities of the different stakeholders involved: patients, doctors, pharmaceutical firms and public authorities. To facilitate the governance of the national obligations under the Convention, a coordinating body should be set up, under the leadership of the World Health Organization and the Stop TB Partnership. Summary: Successfully implementing policies for tuberculosis that simultaneously address patients’ rights and communities’ wellbeing will have positive implications for those affected by the disease and serve as a basis for other global health conventions to truly ensure the global right to health.
PERSPECTIVAS DA TERMINOLOGIA NA CONCEPÇÃO DE UM DICIONÁRIO MULTILINGUE DE ESPECIALIDADE
Creators: name: Moreira Da Silva, Manuel
Publisher: name: POLISSEMA – Revista de Letras do ISCAP
Year: 2019

description: Uma das abordagens mais importantes da terminologia é a desenvolvida pelas disciplinas técnico-científicas, para as quais representa a reflexão formal da sua organização conceptual e, como tal, um meio essencial de expressão e comunicação. De forma a desenvolver as diferentes tarefas a que se propõe, a terminologia tem como principal objecto de estudo os textos de línguas de especialidade, que são o primeiro veículo, por excelência, de expressão e comunicação das disciplinas suprareferidas. Estes textos reflectem, normalmente, um tipo de comunicação especializada, cujo objectivo é o da transferência de conhecimentos, realizada com recurso a um sistema de representação verbal. No entanto, a abertura e a extensão do texto escrito a outros meios de representação, sobretudo nas áreas técnicas, está a conduzir a uma nova tendência no campo da terminologia e da pesquisa das línguas de especialidade, que tem vindo a reforçar a importância da utilização de formas não-verbais para representar o conhecimento. A tendência para o aumento do uso destas formas de representação, normalmente em complemento ou conjugação com a informação verbal, aponta para um novo paradigma em que a linguagem, como representação do pensamento, parece estar em busca de uma nova abordagem que venha transformar a maneira de produzir, organizar e transmitir conhecimentos, recorrendo às novas tecnologias, cada vez mais à disposição da chamada sociedade do conhecimento. A nossa percepção desta realidade ganhou maior consistência ao longo do desenvolvimento de um projecto terminográfico de elaboração do Dicionário Multilingue de População e Desenvolvimento, no qual o recurso a sistemas de representação não-verbais (organigramas e outro tipo de representações visuais), utilizados como forma de percepção e organização dos conceitos e dos domínios a incluir no dicionário, se tornou um meio importante de aquisição, discussão, estruturação e transmissão do conhecimento. Daí a decisão de abordarmos, ainda que de forma breve, a análise de duas problemáticas sugeridas pelo desenrolar daquele projecto. A primeira recai sobre o estabelecimento de relações semânticas entre os conceitos, sobre as implicações deste processo na estruturação conceptual e sobre a sua importância no processamento da informação terminológica. A segunda incide na análise do recurso aos meios de representação não-verbais e do papel que desempenham e que podem vir a desempenhar no desenrolar do processo terminológico, enquanto elementos de estruturação de um sistema conceptual, de estruturação de um projecto terminológico e de comunicação especializada. Estas duas problemáticas estão directamente interrelacionadas e devem ser analisadas em conjunto, sobretudo quando se trata de formalizar a informação e armazená-la numa base de dados terminológica, de forma a poder ser processada (semi)automaticamente.
description: POLISSEMA – Revista de Letras do ISCAP, No. 5 (2005)
DIDEROT, LE GRAND SATIRIQUE
Creators: name: Pinho Lucas De Freitas De Carvalho Pedrosa, Lúcia Margarida
Publisher: name: POLISSEMA – Revista de Letras do ISCAP
Year: 2019

description: Diderot est davantage un humaniste et un non-conformiste qui se préoccupe beaucoup de la stabilité et du confort de l’existence humaine. Il croit que l’homme est né pour vivre en société et qu’il doit être heureux. Toute cette philosophie ressort de ses oeuvres dont l’objectif est celui d’aider les hommes à atteindre le bonheur: il s’agit donc d’une littérature engagée. La verve satirique de Diderot est le fil directeur d’une oeuvre variée et diverse qui risque de décourager le lecteur paresseux. L’élément satirique rassemble les articles de L’Encyclopédie, les Salons et les oeuvres fictives de Diderot, comme par exemple, Le Neveu de Rameau, Jacques le Fataliste et son Maître et La Religieuse. Bien que L’Encyclopédie soit une entreprise scientifique, Diderot cache, dans plusieurs articles, pour tromper la censure, des attaques virulentes contre la morale, la religion et ses institutions. Il critique aussi les superstitions et les croyances dont s’entourent les religions. Dans les Salons, Diderot rédige des appréciations sur les tableaux de quelques peintres, parus dans plusieurs expositions. Mais Diderot ne les décrit pas en tant que technicien, il s’en sert pour faire une parodie de ces peintures, utilisant très souvent un langage grossier et un style gaillard. La satire est le lien entre la non-fiction et la fiction. Dans ses oeuvres romanesques on trouve la satire sociale et littéraire : Diderot y met en question le genre romanesque traditionnel, par conséquent Le Neveu de Rameau, Jacques le Fataliste et son Maître et La Religieuse se caractérisent par un décousu apparent et désordonné – c’est la forme amusante dont Diderot se sert pour révéler aux lecteurs que les romans traditionnels les trompent. La forme désorganisée sert aussi à montrer le manque de liberté dont l’homme jouit – l’homme n’est qu’un guignol manipulé par le destin. En effet, en « déconstruisant » le roman, Diderot oblige le lecteur à réfléchir sur la condition humaine et l’illusion romanesque de telle façon que le lecteur ne sait plus ce qui est faux et ce qui est vrai, surtout dans le cas de La Religieuse.
description: POLISSEMA – Revista de Letras do ISCAP, No. 5 (2005)
Geometry for separable states and construction of entangled states with positive partial transposes
Creators: name: Ha, Kil-Chan
name: Kye, Seung-Hyeok
Publisher: name: arXiv
Year: 2013
Subjects: subject: Quantum Physics (quant-ph)
subject: Operator Algebras (math.OA)
subject: FOS: Physical sciences
subject: FOS: Mathematics
subject: 81P15, 15A30, 46L05

description: We construct faces of the convex set of all $2\otimes 4$ bipartite separable states, which are affinely isomorphic to the simplex $Δ_{9}$ with ten extreme points. Every interior point of these faces is a separable state which has a unique decomposition into 10 product states, even though ranks of the state and its partial transpose are 5 and 7, respectively. We also note that the number 10 is greater than $2\times 4$, to disprove a conjecture on the lengths of qubit-qudit separable states. This face is inscribed in the corresponding face of the convex set of all PPT states so that sub-simplices $Δ_k$ of $Δ_{9}$ share the boundary if and only if $k\le 5$. This enables us to find a large class of $2\otimes 4$ PPT entangled edge states with rank five.
description: 8 pages, 2 figures
«D. JUAN» DE E.T.A. HOFFMANN E «DON GIONVANNI» DE LORENZO DA PONTE
Creators: name: Guimarães, Maria Helena
Publisher: name: POLISSEMA – Revista de Letras do ISCAP
Year: 2019

description: Através da análise comparativo/intertextual do conto Don Juan, de E.T.A. Hoffmann e do libreto da ópera Don Giovanni, de Mozart, da autoria de Lorenzo da Ponte, o objectivo deste artigo foi pôr em relevo a relação intrínseca, presente em muitas das obras de E.T.A. Hoffmann, entre a escrita e a música, explicável pela enorme sensibilidade musical deste autor, a que não só dedicou a sua vida, como também produziu várias obras musicais. Tal como na ópera Don Giovanni, de Mozart, a escrita de Hoffmann é dirigida por uma batuta imaginária, apresentando o suspense próprio dos enigmas, cuja revelação é suspensa por um entreacto – neste caso, uma carta escrita a um amigo, em que nos é apresentada uma reformulação do mito de Don Juan – entreacto este que vem prolongar o mistério e nos encaminha para um finale, em que a progressão da melodia e a sequência narrativa se unem mais uma vez. Por seu turno, na análise puramente intertextual, é feita uma tentativa de estabelecer, de forma clara, os paralelismos existentes com o pré-texto, isto é, com o libreto da autoria de Lorenzo da Ponte, bem como com outros pré-textos presentes no texto de forma mais esbatida, mas cujo peso é, também ele, significativo para a criação do novo mito de Don Juan, um homem sempre consciente do absurdo da existência, interpretação esta que abriu caminho para novas abordagens do mito, do herói e da história. Tal como em muitas outras obras, o pós-texto procura, em geral, apropriar-se do texto pressuposto, tentando ultrapassá-lo em mestria, o que acontece com este texto de Hoffmann, literária e semanticamente mais rico que o seu pré-texto.
description: POLISSEMA – Revista de Letras do ISCAP, No. 5 (2005)
title: R/V NATSUSHIMA Cruise report NT07-03
Creators: name: Kasaya, Takafumi
Publisher: name: JAMSTEC
Year: 2007
Subjects: subject: Cruise report
subject: R/V NATSUSHIMA
subject: oceans

description: [CRUISE REPORT] This document is a preliminary report of NT07-03 on R/V NATSUSHIMA from 2007-02-10 to 2007-02-12.
CONSTRUÇÕES DE FOCALIZAÇÃO NA IMPRENSA INGLESA
Creators: name: Lopes, Dalila
Publisher: name: POLISSEMA – Revista de Letras do ISCAP
Year: 2019

description: Este artigo consiste na análise do uso de construções de focalização na imprensa inglesa, utilizando como corpus a edição de 9 de Março de 2005 do jornal britânico The Guardian, International Edition. As construções de focalização aqui tratadas são basicamente as catalogadas por Erdmann (1990) e Tschida (1995). Todas as ocorrências tiradas do citado corpus são devidamente co-textualizadas, e comentadas em termos de sintaxe de frase e de texto.
description: POLISSEMA – Revista de Letras do ISCAP, No. 5 (2005)
title: After School Programs: Resiliency Through Recreation
Creators: name: Johnston, Aaron
Publisher: name: Old Dominion University
publisherIdentifier: https://ror.org/04zjtrb98
publisherIdentifierScheme: ROR
Year: 2009

description: The purpose of this study was to examine a resiliency based after school intervention program and its effects on the development of at risk youth in a public middle school. A middle school was chosen from the Norfolk Public School System in Norfolk, Virginia. Undergraduate college students led multiple resiliency-based activities during the immediate after school hours, concluding with an educational session. Data were collected by administers via pre test and post test. Confirmatory factor analysis (CFA) was used to determine the uni-dimensionality of the resiliency traits. The CF A provided for six traits. Results did not confirm an increase in resiliency scores from pre to post test. Of the six dimensions, only the "relationship" dimension showed a significant difference between boys and girls. The results of the present study were discussed in reference to the previous research on after school programs and their benefits. Conclusions on the effects of a resiliency based after school program were then reported and possible areas of future research were proposed.
Complete Response to Pembrolizumab in a Patient with Lynch Syndrome A Case Report.pdf
Creators: name: ALakkad, Ashraf
Publisher: name: figshare
Year: 2022
Subjects: Other health sciences not elsewhere classified

description: Background: Lynch syndrome LS is a life-threatening condition caused by heterozygous mutations in mismatch repair genes (MMR). People with this syndrome are at increased risk of developing different types of cancers, such as colorectal carcinomas, endometrial cancer, and ovarian cancers. Case report: The present case report discusses the case of a 36-year-old non-diabetic non- alcoholic female who came to the oncology department with a known history of Lynch syndrome. The patient had a significant past medical history. In 2003, she was diagnosed with left colon cancer for which she had left hemicolectomy followed by adjuvant chemotherapy. In 2004, she developed duodenal cancer for which she had Whipple surgery. Then, she developed ovarian cancer on both sides, which was also treated by surgery and adjuvant chemotherapy. After that, she developed uterine cancer, treated by surgery and adjuvant chemotherapy. The patient had a total colectomy and she underwent two ileostomy procedures. In 2014, immunohistochemistry testing confirmed the diagnosis that she was suffering from Lynch syndrome. Additionally, cancer sequencing panel testing in 2016 and MSH testing in 2018 further confirmed the diagnosis of Lynch syndrome as only the loss of nuclear expression of the PMS2 gene was revealed. Then in 2018, she developed a peritoneal metastasis of ovarian origin. This was the first time she started Pembrolizumab immunotherapy, that was finished at the end of 2019. One intriguing fact is that all her diseases cleared up and she continues to live normal life four years after stopping immunotherapy and she is in complete remission. Also, all her tumor markers have dropped down and normalized. Conclusion: Carrying the PMS2 germline mutation confers an extraordinarily high risk of developing LS-associated cancers. To decrease the morbidity and mortality associated with LS- related cancers, intensive clinical monitoring, pembrolizumab therapy, and preventive surgeries are strongly advised.
title: R/V NATSUSHIMA Cruise report NT07-01
Creators: name: Goto, Tadanori
Publisher: name: JAMSTEC
Year: 2007
Subjects: subject: Cruise report
subject: R/V NATSUSHIMA
subject: oceans

description: [CRUISE REPORT] This document is a preliminary report of NT07-01 on R/V NATSUSHIMA from 2007-01-05 to 2007-01-12.
Development of a culturally sensitive Arabic version of the Mini International Neuropsychiatric Interview (M.I.N.I.-AR) and validation of the depression module
Creators: name: Karnouk, Carine
name: Böge, Kerem
name: Lindheimer, Nico
name: Churbaji, Dana
name: Abdelmagid, Shaymaa
name: Mohamad, Sara
name: Hahn, Eric
name: Bajbouj, Malek
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Validation
subject: Mini International Neuropsychiatric Interview (M.I.N.I.)
subject: Psychiatric diagnosis
subject: Arabic
subject: Cultural adaptation
subject: Assessment
subject: Arabic-speakers
subject: Refugee
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Arabic represents one of the most frequently spoken languages worldwide, especially among refugee populations. There is a pressing need for specialized diagnostic tools corresponding to the DSM-5 criteria in Modern Standard Arabic, which can be administered on Arabic speakers in the West and Arab region alike. Objectives: To develop and validate the culturally-adapted version of the most recent M.I.N.I. 7.0.2 into Modern Standard Arabic-a form of Arabic commonly used across all Arab countries. Methods: 102 participants were recruited between April 2019 to March 2020 at the Charite - Universitatsmedizin in Berlin. Symptoms were assessed with Arabic versions of rater-based and self-rated measures, including Mini International Neuropsychiatric Interview (M.I.N.I.), Patient Health Questionnaire (PHQ-9), and Harvard Trauma Questionnaire (HTQ). Arabic-speaking psychiatrists saw participants for diagnostic assessment. Results: Cohen's kappa (kappa) values were moderate for major depression, and slight for post-traumatic stress disorder, as well as generalized anxiety disorder. Moreover, kappa values indicated moderate agreement between M.I.N.I.-AR and PHQ-9 for depression, as well as HTQ for post-traumatic stress disorder, respectively. Conclusion: The translated and culturally adapted version of the M.I.N.I. addresses an existing need for a reliable, efficient, and effective comprehensive diagnostic tool using the most recent DSM-5 criteria in Modern Standard Arabic (MSA). Based on the obtained results, only a validation of the depression module (Module A) of the M.I.N.I-AR was possible. Study outcomes also show evidence for the validation of Module H covering Post-Traumatic Stress Disorder. Potential valuable contributions can be extended to this translation and validation.
title: Yokosuka Cruise Report YK21-08C
Creators: name: Nomaki, Hidetaka
Publisher: name: JAMSTEC
Year: 2021
Subjects: subject: Cruise report
subject: S/V YOKOSUKA
subject: oceans

description: [CRUISE REPORT] This document is a preliminary report of YK21-08C on S/V YOKOSUKA from 2021-05-10 to 2021-05-28.
WORKING "IN" AND "ON" GROUPS: AN ILLUSTRATION OF THE PRINCIPLES OF EXPLORATORY PRACTICE IN AN ESP CLASSROOM
Creators: name: Pinto Da Silva, Cristina
Publisher: name: POLISSEMA – Revista de Letras do ISCAP
Year: 2019

description: .
description: POLISSEMA – Revista de Letras do ISCAP, No. 5 (2005)
Taxing the Poor: State Income Tax Policies Make a Big Difference to Working Families
Creators: name: Hartig, Seth
name: Skinner, Curtis
name: Ekono, Mercedes M.
Publisher: name: Columbia University
Year: 2014
Subjects: Income tax--U.S. states
Earned Income Tax Credit
Poor families
Working poor
Working poor--Government policy

description: An NCCP analysis of state tax policy finds that a significant number of states continue to push the working poor deeper into poverty by imposing income tax liabilities on poverty-level earnings–liabilities that in some states reach hundreds of dollars. In contrast to states that tax the poor, a growing number of states offer supports to poor families through refundable tax credits, providing income supplements that that can reach up to almost two thousand dollars per family.
Measurement of the inclusive isolated prompt photon cross section in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector using 4.6 fb-1
Creators: name: ATLAS Collaboration
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: A measurement of the cross section for the production of isolated prompt photons in pp collisions at a center-of-mass energy sqrt(s) = 7 TeV is presented. The results are based on an integrated luminosity of 4.6 fb-1 collected with the ATLAS detector at the LHC. The cross section is measured as a function of photon pseudorapidity and transverse energy in the kinematic range between 100 GeV and 1000 GeV and in the regions of pseudorapidity less than 1.37 and between 1.52 and 2.37. The results are compared to leading-order parton-shower Monte Carlo models and next-to-leading-order perturbative QCD calculations. Next-to-leading-order perturbative QCD calculations agree well with the measured cross sections as a function of transverse energy and pseudorapidity.
description: 12 pages plus author list (24 pages total), 7 figures, 3 tables, submitted to Phys. Rev. D. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2012-16/
Promising antibacterials for LLM of Staphylococcus aureus using virtual screening, molecular docking, dynamics, and MMPBSA
Creators: name: Rathi, Ravi
name: Kumari, Reena
name: Pathak, Seema R.
name: Dalal, Vikram
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: In S. aureus, lipophilic membrane (LLM) protein is a methicillin resistance factor and is an essential role in peptidoglycan metabolism. The virtual screening of antibacterial molecules against the model of LLM was performed to identify the potent antibacterial molecules. Molecular docking results of pharmacokinetic filtered molecules illustrated that five molecules had higher binding affinities than tunicamycin (TUM) and were stabled via non-covalent interactions (hydrogen bond and hydrophobic interactions) at the active site of LLM. Further, molecular dynamics results revealed that binding of identified antibacterial molecules with LLM resulted in stable LLM-inhibitor(s) complexes. Molecular Mechanics/Position-Boltzmann Surface Area (MMPBSA) analysis showed that LLM-inhibitor(s) complexes had high binding affinities in the range of −213.49 ± 2.24 to −227.42 ± 3.05 kJ/mol. The amino acid residues decomposition analysis confirmed that identified antibacterial molecules bound at the active site (Asn148, Leu149, Asp151, Asp208, His269, His271, and His272) of LLM. Noticeably, the current study found five antibacterial molecules (BDE 27575101, BDE 33638168, BDE 33672484, LAS 51502073, and BDE 25098678) were highly potent than TUM and even than earlier reported molecules. Therefore, here reported antibacterial molecules may be used directly or developed to inhibit LLM of S. aureus. Communicated by Ramaswamy H. Sarma
Axioms for Definability and Full Completeness
Creators: name: Abramsky, Samson
Publisher: name: arXiv
Year: 2014
Subjects: subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences

description: Axioms are presented which encapsulate the properties satisfied by categories of games which form the basis of results on full abstraction for PCF and other programming languages, and on full completeness for various logics and type theories. Axioms are presented on models of PCF from which full abstraction can be proved. These axioms have been distilled from recent results on definability and full abstraction of game semantics for a number of programming languages. Full completeness for pure simply-typed $λ$-calculus is also axiomatized.
description: 18 pages
The Berlin Exoplanet Search Telescope II. Catalog of Variable Stars. I. Characterization of Three Southern Target Fields
Creators: name: Fruth, T.
name: Cabrera, J.
name: Chini, R.
name: Csizmadia, Sz.
name: Dreyer, C.
name: Eigmüller, P.
name: Erikson, A.
name: Kabath, P.
name: Kirste, S.
name: Lemke, R.
name: Murphy, M.
name: Pasternacki, T.
name: Rauer, H.
name: Titz-Weider, R.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: A photometric survey of three Southern target fields with BEST II yielded the detection of 2,406 previously unknown variable stars and an additional 617 stars with suspected variability. This study presents a catalog including their coordinates, magnitudes, light curves, ephemerides, amplitudes, and type of variability. In addition, the variability of 17 known objects is confirmed, thus validating the results. The catalog contains a number of known and new variables that are of interest for further astrophysical investigations, in order to, e.g., search for additional bodies in eclipsing binary systems, or to test stellar interior models. Altogether, 209,070 stars were monitored with BEST II during a total of 128 nights in 2009/2010. The overall variability fraction of 1.2-1.5% in these target fields is well comparable to similar ground-based photometric surveys. Within the main magnitude range of $R\in\left[11,17\right]$, we identify 0.67(3)% of all stars to be eclipsing binaries, which indicates a completeness of about one third for this particular type in comparison to space surveys.
description: accepted to AJ
Image Quality Assessment for Fetal MRI
Creators: name: Junshen Xu
Publisher: name: Zenodo
Year: 2022
Subjects: deep learning
fetal MRI
Image quality assessment

description: This repo contains the pre-trained models of the following works. [1] A deep learning approach for image quality assessment of fetal brain MRI, ISMRM 2019 [2] Semi-supervised learning for fetal brain MRI quality assessment with ROI consistency, MICCAI 2020 [3] Automated detection and reacquisition of motion-degraded images in fetal HASTE imaging at 3 T, MRM See https://github.com/daviddmc/fetal-IQA for details.
Investigation of spleen CXCR4 expression by [68Ga]Pentixafor PET in a cohort of 145 solid cancer patients
Creators: name: Lewis, Richard
name: Habringer, Stefan
name: Kircher, Malte
name: Hefter, Maike
name: Peuker, Caroline Anna
name: Werner, Rudolf
name: Ademaj-Kospiri, Valëza
name: Gäble, Alexander
name: Weber, Wolfgang
name: Wester, Hans-Jürgen
name: Buck, Andreas
name: Herhaus, Peter
name: Lapa, Constantin
name: Keller, Ulrich
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: Solid tumors
subject: Clinical studies
subject: Retrospective studies
subject: Molecular imaging
subject: PET
subject: CXCR4
subject: Pentixafor
subject: Spleen
subject: Uptake
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: The chemokine receptor CXCR4 is frequently overexpressed and associated with adverse prognosis in most hematopoietic malignancies and solid cancers. Recently, CXCR4 molecular imaging using the CXCR4-specific positron emission tomography (PET) tracer Pentixafor ([Ga-68]Pentixafor) has become a well-established method to non-invasively measure CXCR4 expression in vivo. In previous Pentixafor imaging studies, highly variable CXCR4 tracer uptake to the spleen was observed. Results: We investigated the hypothesis that enhanced spleen [Ga-68]Pentixafor uptake and thus CXCR4 expression in patients with solid tumors would indicate an activated spleen state and/or an association with clinical and prognostic features and survival parameters. In this retrospective study, [Ga-68]Pentixafor-PET images and patient records of 145 solid tumor patients representing 27 cancer entities were investigated for an association of spleen [Ga-68]Pentixafor uptake and clinical characteristics and outcome. Based on this assessment, we did not observe differences in clinical outcomes, measured by progression-free survival, overall survival and remission status neither within the entire cohort nor within subgroups of adrenal cancer, desmoplastic small round cell tumor, neuroendocrine tumors, non-small cell lung cancer, small cell lung cancer and pancreatic adenocarcinoma patients. No tumor entity showed especially high levels of spleen [Ga-68]Pentixafor uptake compared to others or a control cohort. However, when investigating laboratory parameters, there was a positive correlation of high spleen [Ga-68]Pentixafor uptake with leukocyte and/or platelet counts in neuroendocrine tumors, non-small cell lung cancer and small cell lung cancer. Conclusion: Spleen [Ga-68]Pentixafor uptake was not associated with stage of disease and clinical outcomes in solid tumor patients. We identified positively associated platelet and/or leukocyte counts with spleen [Ga-68]Pentixafor uptake in neuroendocrine tumors, non-small cell lung cancer and small cell lung cancer, suggesting that splenic CXCR4 expression could possibly play a role in systemic immunity/inflammation in some types of solid tumors or a subgroup of patients within solid tumor entities.
TRAGÉDIA DA CONSCIÊNCIA NO CONTO DE MACHADO DE ASSIS
Creators: name: Sarmento, Clara
Publisher: name: POLISSEMA – Revista de Letras do ISCAP
Year: 2019

description: Neste ensaio, o conto O Caso da Vara de Machado de Assis é lido não só como uma história irónica, cuidadosamente estruturada, de conflitos internos versus acções reais, mas também como uma potencial peça dramática que partilha das características da tragédia clássica. As acções das personagens são vencidas pela torrente dos seus pensamentos, medos, crueldades e dramas, conduzindo a narrativa até um desfecho enigmático e sempre adiado. Tal como no drama clássico, n’O Caso da Vara notamos a predilecção de Machado de Assis por situações universais que revelam a feição trágico-cómica dos comportamentos instituídos, num conto carregado de implicações morais que despertam o leitor para as grandes intenções e ainda maiores cobardias do ser humano.
description: POLISSEMA – Revista de Letras do ISCAP, No. 5 (2005)
Identifying inhibitors of NSP16-NSP10 of SARS-CoV-2 from large databases
Creators: name: Nguyen, Hoang Linh
name: Thai, Nguyen Quoc
name: Li, Mai Suan
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: The COVID-19 pandemic, which has already claimed millions of lives, continues to pose a serious threat to human health, requiring the development of new effective drugs. Non-structural proteins of SARS-CoV-2 play an important role in viral replication and infection. Among them, NSP16 (non-structured protein 16) and its cofactor NSP10 (non-structured protein 10) perform C2'-O methylation at the 5' end of the viral RNA, which promotes efficient virus replication. Therefore, the NSP16-NSP10 complex becomes an attractive target for drug development. Using a multi-step virtual screening protocol which includes Lipinski’s rule, docking, steered molecular dynamics and umbrella sampling, we searched for potential inhibitors from the PubChem and anti-HIV databases. It has been shown that CID 135566620 compound from PubChem is the best candidate with an inhibition constant in the sub-μM range. The Van der Waals interaction was found to be more important than the electrostatic interaction in the binding affinity of this compound to NSP16-NSP10. Further in vitro and in vivo studies are needed to test the activity of the identified compound against COVID-19. Communicated by Ramaswamy H. Sarma
title: Yokosuka Cruise Report YK21-18C
Creators: name: Nomaki, Hidetaka
Publisher: name: JAMSTEC
Year: 2021
Subjects: subject: Cruise report
subject: S/V YOKOSUKA
subject: oceans

description: [CRUISE REPORT] This document is a preliminary report of YK21-18C on S/V YOKOSUKA from 2021-09-28 to 2021-10-16.
THREE POOR JOBS: JEWISH, AMERICAN, AND HONG KONG
Creators: name: Chen, Chapman
Publisher: name: POLISSEMA – Revista de Letras do ISCAP
Year: 2019

description: Objective: To find out how Ngo Loudou Hai Dongfui [My Father is Ash of the Party], a Hong Kong Cantonese rewriting of Neil Simon’s God’s Favorite, which is in turn an American rewriting of the Biblical story of Job, reflects the socio-political ideology of Hong Kong. Methodology: 1. Andre Lefevere (1992) argues that translation and adaptation are rewriting informed and influenced by the rewriter’s ideology. 2. Sirkku Aaltonen (2000) argues that whatever its self-proclaimed intentions, the selection of foreign plays is never an innocent decision, but rather a response to a wholly specific situation within one’s own culture and society. 3. In 2003, five to six years after the handover of Hong Kong from Britain to China, the Hong Kong government had proved itself to be grossly incompetent and the frustration of the Hong Kong citizens can be seen, for example, in one of the representative translated play performed there during the period, which originated from Neil Simon’s God’s Favorite. The religious theme of the former is turned political, and the time-space of the latter is changed from Long Island Sound in the 70s to Hong Kong in 1995.
description: POLISSEMA – Revista de Letras do ISCAP, No. 5 (2005)
How do the mutations in PfK13 protein promote anti-malarial drug resistance?
Creators: name: Sharma, Shikha
name: Ali, Md. Ehesan
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Plasmodium falciparum develops resistance to artemisinin upon exposure to the anti-malarial drug. Various mutations in the Plasmodium falciparum Kelch13 (PfK13) protein such as Y493H, R539T, I543T and C580Y have been associated with anti-malarial drug resistance. These mutations impede the regular ubiquitination process that eventually invokes drug resistance. However, the relationship between the mutation and the mechanism of drug resistance has not yet been fully elucidated. The comparative protein dynamics are studied by performing the classical molecular dynamics (MD) simulations and subsequent analysis of the trajectories adopting root-mean-square fluctuations, the secondary-structure predictions and the dynamical cross-correlation matrix analysis tools. Here, we observed that the mutations in the Kelch-domain do not have any structural impact on the mutated site; however, it significantly alters the overall dynamics of the protein. The loop-region of the BTB-domain especially for Y493H and C580Y mutants is found to have the enhanced dynamical fluctuations. The enhanced fluctuations in the BTB-domain could affect the protein–protein (PfK13-Cullin) binding interactions in the ubiquitination process and eventually lead to anti-malarial drug resistance. Communicated by Ramaswamy H. Sarma
A helical jet model for OJ287
Creators: name: Valtonen, Mauri
name: Pihajoki, Pauli
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Context. OJ287 is a quasar with a quasi-periodic optical light curve, with the periodicity observed for over 120 years. This has lead to a binary black hole model as a common explanation of the quasar. The radio jet of OJ287 has been observed for a shorter time of about 30 years. It has a complicated structure that varies dramatically in a few years time scale. Aims. Here we propose that this structure arises from a helical jet being observed from a small and varying viewing angle. The viewing angle variation is taken to be in tune with the binary orbital motion. Methods. We calculate the effect of the secondary black hole on the inner edge of the accretion disk of the primary using particle simulations. We presume that the axis of the helix is perpendicular to the disk. We then follow the jet motion on its helical path and project the jet to the sky plane. This projection is compared with observations both at mm waves and cm waves. Results. We find that this model reproduces the observations well if the changes in the axis of the conical helix propagate outwards with a relativistic speed of about 0.85c. In particular, this model explains at the same time the long-term optical brightness variations as varying Doppler beaming in a component close to the core, i.e. at parsec scale in real linear distance, while the mm and cm radio jet observations are explained as being due to jet wobble at much larger (100 parsec scale) distances from the core.
description: 5 pages, 7 figures, to be published in Astronomy & Astrophysics
Identification of novel inhibitors of Neisseria gonorrhoeae MurI using homology modeling, structure-based pharmacophore, molecular docking, and molecular dynamics simulation-based approach
Creators: name: Kant, Ravi
name: Jha, Prakash
name: Saluja, Daman
name: Chopra, Madhu
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer

description: MurI is one of the most significant role players in the biosynthesis of the peptidoglycan layer in Neisseria gonorrhoeae (Ng). We attempted to highlight the structural and functional relationship between Ng-MurI and D-glutamate to design novel molecules targeting this interaction. The three-dimensional (3D) model of the protein was constructed by homology modeling and the quality and consistency of generated model were assessed. The binding site of the protein was identified by molecular docking studies and a pharmacophore was identified using the interactions of the control ligand. The structure-based pharmacophore model was validated and employed for high-throughput virtual screening and molecular docking to identify novel Ng-MurI inhibitors. Finally, the model was optimized by molecular dynamics (MD) simulations and the optimized model complex with the substrate glutamate and novel molecules facilitated us to confirm the stability of the protein-ligand docked complexes. The 100 ns MD simulations of the potential lead compounds with protein confirmed that the modeled complexes were stable. This study identifies novel potential compounds with good fitness and docking scores, which made the interactions of biological significance within the protein active site. Hence, the identified compounds may act as new leads to design and develop Ng-MurI inhibitors. Communicated by Ramaswamy H. Sarma