cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Dissecting the Bond Formation Process of $d^{10}$-Metal-Ethene Complexes with Multireference Approaches
Creators: name: Zhao, Yilin
name: Boguslawski, Katharina
name: Tecmer, Paweł
name: Duperrouzel, Corinne
name: Barcza, Gergely
name: Legeza, Örs
name: Ayers, Paul W.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: The bonding mechanism of ethene to a nickel or palladium center is studied by the density matrix renormalization group algorithm, the complete active space self consistent field method, coupled cluster theory, and density functional theory. Specifically, we focus on the interaction between the metal atom and bis-ethene ligands in perpendicular and parallel orientations. The bonding situation in these structural isomers is further scrutinized using energy decomposition analysis and quantum information theory. Our study highlights the fact that when two ethene ligands are oriented perpendicular to each other, the complex is stabilized by the metal-to-ligand double-back-bonding mechanism. Moreover, we demonstrate that nickel-ethene complexes feature a stronger and more covalent interaction between the ligands and the metal center than palladium-ethene compounds with similar coordination spheres.
description: 13 pages, 9 figures
An Important Role of CDK Inhibitor p18INK4c in Modulating Antigen Receptor-Mediated T Cell Proliferation
Creators: name: Su, L.
name: Coffield, V. M.
name: Xiong, Y.
name: Kovalev, G. I.
name: Franklin, D. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2001

description: The inhibitors of cyclin-dependent kinase (CDK) 4 (INK4) bind CDK4/6 to prevent their association with D-cyclins and G1 cell cycle initiation and progression. We report here that among the seven CDK inhibitors, p18INK4c played an important role in modulating TCR-mediated T cell proliferation. Loss of p18INK4c in T cells led to hyperproliferation in response to CD3 stimulation. p18INK4c-null mice developed lymphoproliferative disorder and T cell lymphomas. Expression of IL-2, IL-2R-a, and the major G1 cell cycle regulatory proteins was not altered in p18-null T cells. Both FK506 and rapamycin efficiently inhibited proliferation of p18-null T cells. In activated T cells, p18INK4c remained constant, and preferentially associated with and inhibited CDK6 but not CDK4. We propose that p18INK4c sets an inhibitory threshold in T cells and one function of CD28 costimulation is to counteract the p18INK4c inhibitory activity on CDK6-cyclin D complexes. The p18INK4c protein may provide a novel target to modulate T cell immunity.
New possibilities through Puredyne print heads for bioprinting
Creators: name: Gruber, Felix
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2022

description: While the additive manufacturing of polymers and powder has already found its way into the industry is bioprinting reps. regenerative medicine still at the beginning of a professional process. The brand Puredyne deliver with the endless piston principle and the single use cartridges a new extrusion head for bioprinting. This volumetric dispensing process is based on extrusion-based technology. The combination allows more precision and a high repeatability for viscous biomaterials. The researcher can be more focused on the development of the biomaterials and offers new opportunities in handling of viscous materials. Bioprinting print head with single-use cap. The compact print head with integrated compressed air supply is mounted as a multi-use component on a 3D printer or bioprinter. A stepper motor provides simple control; no additional control system is required. The print head is supplemented by patented single-use caps. In this, eccentric screw technology is the key to maximum precision. The cap comprises a volume reservoir of 5 ml and is replaced after the dispensing process. The exchange process guarantees absolute safety: there is no cross-contamination, as only one material is used per cartridge. The Luer lock connection at the lower end of the cap allows a wide range of different dispensing needles. Eccentric screw technology in bioprinting: Eccentric screw technology is predestined for volumetric dispensing of low- to high-viscosity biomaterials. Precision, repeatability, process reliability and intuitive handling are the core competencies of ViscoTec technology. Materials of a wide range of viscosities are applied reliably and precisely - for a perfect print result. Environmental influences can be virtually neglected in the printing process thanks to the reliable technology. Due to the metering geometry, a constant volume is always conveyed and precisely applied per revolution. The option of reversing the conveying direction ensures clean start and end points.
description: Transactions on Additive Manufacturing Meets Medicine, Vol. 4 No. S1 (2022): Trans. AMMM Supplement
EBV-Encoded Latent Membrane Protein 1 Cooperates with BAFF/BLyS and APRIL to Induce T Cell-Independent Ig Heavy Chain Class Switching
Creators: name: Cerutti, Andrea
name: He, Bing
name: Casali, Paolo
name: Raab-Traub, Nancy
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: By substituting the H chain C region of IgM with that of IgG, IgA, or IgE, class switching enables Abs to acquire new effector functions that are crucial for the neutralization of invading pathogens. Class switching occurs through class switch DNA recombination (CSR) and usually requires engagement of CD40 on B cells by CD40 ligand on Ag-activated CD4+ T cells. CSR must be tightly regulated because abnormal IgG and IgA production favors the onset of autoimmunity, whereas increased switching to IgE leads to atopy. These inflammatory disorders can be triggered or exacerbated by EBV infection. In this study, we show that EBV induces CD40-independent CSR from Cµ to multiple downstream Cγ, Cα, and C∊ genes through latent membrane protein 1 (LMP1), a CD40-like viral protein that signals in a ligand-independent fashion. LMP1-induced CSR is associated with transcriptional activation of germline Cγ, Cα, and C∊ genes and triggers the up-regulation of activation-induced cytidine deaminase, a crucial component of the CSR machinery. In addition, LMP1 induces B cells to express B cell-activating factor of the TNF family and a proliferation-inducing ligand, two molecules that mediate B cell survival and T cell-independent Ab production. B cell-activating factor of the TNF family and a proliferation-inducing ligand cooperate with LMP1 to induce Ig class switching because their neutralization by appropriate soluble decoy receptors attenuates CSR in LMP1-expressing B cells. By showing that LMP1 triggers T cell-independent CSR, our findings suggest that EBV could play an important role in the pathogenesis of disorders with aberrant IgG, IgA, and/or IgE production.
Interplay between TCR Affinity and Necessity of Coreceptor Ligation: High-Affinity Peptide-MHC/TCR Interaction Overcomes Lack of CD8 Engagement
Creators: name: Buslepp, Jennifer
name: Hensley, Lucinda L.
name: Cramer, Lorraine A.
name: Kerry, Samantha E.
name: Kavathas, Paula
name: Vilen, Barbara J.
name: Nielsen, Alma I.
name: Frelinger, Jeffrey A.
name: Collins, Edward J.
name: Maile, Robert
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2003

description: CD8 engagement is believed to be a critical event in the activation of naive T cells. In this communication, we address the effects of peptide-MHC (pMHC)/TCR affinity on the necessity of CD8 engagement in T cell activation of primary naive cells. Using two peptides with different measured avidities for the same pMHC-TCR complex, we compared biochemical affinity of pMHC/TCR and the cell surface binding avidity of pMHC/TCR with and without CD8 engagement. We compared early signaling events and later functional activity of naive T cells in the same manner. Although early signaling events are altered, we find that high-affinity pMHC/TCR interactions can overcome the need for CD8 engagement for proliferation and CTL function. An integrated signal over time allows T cell activation with a high-affinity ligand in the absence of CD8 engagement.
Unusual ferromagnetic critical behavior owing to short-range antiferromagnetic correlations in antiperovskite Cu1-xNMn3+x(0.1
Creators: name: Lin, J. C.
name: Tong, P.
name: Cui, D. P.
name: Yang, C.
name: Yang, J.
name: Lin, S.
name: Wang, B. S.
name: Tong, W.
name: Zhang, L.
name: Zou, Y. M.
name: Sun, Y. P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: For ferromagnets, varying from simple metals to strongly correlated oxides,the critical behaviors near the Curie temperature (TC) can be grouped into several universal classes. In this paper, we report an unusual critical behavior in manganese nitrides Cu1-xNMn3+x(0.1
description: 26 pages, 6 figures
Age and growth of Venus verrucosa (Bivalvia: Veneridae) in the eastern Adriatic Sea
Creators: name: PEHARDA, Melita
name: POPOVIĆ, Zvjezdana
name: EZGETA-BALIĆ, Daria
name: VRGOČ, Nedo
name: PULJAS, Sanja
name: FRANKIĆ, Anamarija
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2013

description: The growth rates of Venus verrucosa collected from five locations in the eastern Adriatic Sea were studied using shell-sectioning techniques. At each sampling site, mean shell lengths at ring formation were assessed and von Bertalanffy growth curves fitted. Asymptotic length (L∞) values ranged between 48.2 mm (Istria) to 57.9 mm (Pag Bay) and the growth coefficient (k) from 0.2 year-1 (Pag Bay) to 0.3 year-1 (Istria). Values of phi-prime index (ø') ranged from 6.4 (Starigrad- Paklenica) to 6.7 (Kaštela Bay). Marginal growth increments analysed for individuals collected monthly from Kaštela Bay showed an annual periodicity. That is, translucent (slow growth) increments were added during summer, while opaque (fast growth) increments were deposited during other seasons. Individuals older than ten years were poorly represented in the samples. The obtained data indicate possible differences in levels of exploitation and illustrate the need to establish long- term strategies for the sustainable exploitation of V. verrucosa in the eastern Adriatic.
Human Ribonuclease A Superfamily Members, Eosinophil-Derived Neurotoxin and Pancreatic Ribonuclease, Induce Dendritic Cell Maturation and Activation
Creators: name: Tchernev, Velizar T.
name: Oppenheim, Joost J.
name: Kingsmore, Stephen F.
name: Schweitzer, Barry
name: Rybak, Susanna M.
name: Rosenberg, Helene F.
name: Patel, Dhavalkumar D.
name: Fu, Qin
name: Yang, De
name: Newton, Dianne L.
name: Howard, O. M.Zack
name: Wang, Minjuan
name: Wang, Zhao Yuan
name: Chen, Qian
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2004

description: A number of mammalian antimicrobial proteins produced by neutrophils and cells of epithelial origin have chemotactic and activating effects on host cells, including cells of the immune system. Eosinophil granules contain an antimicrobial protein known as eosinophil-derived neurotoxin (EDN), which belongs to the RNase A superfamily. EDN has antiviral and chemotactic activities in vitro. In this study, we show that EDN, and to a lesser extent human pancreatic RNase (hPR), another RNase A superfamily member, activates human dendritic cells (DCs), leading to the production of a variety of inflammatory cytokines, chemokines, growth factors, and soluble receptors. Human angiogenin, a RNase evolutionarily more distant to EDN and hPR, did not display such activating effects. Additionally, EDN and hPR also induced phenotypic and functional maturation DCs. These RNases were as efficacious as TNF-α, but induced a different set of cytokine mediators. Furthermore, EDN production by human macrophages could be induced by proinflammatory stimuli. The results reveal the DC-activating activity of EDN and hPR and suggest that they are likely participants of inflammatory and immune responses. A number of endogenous mediators in addition to EDN have been reported to have both chemotactic and activating effects on APCs, and can thus amplify innate and Ag-specific immune responses to danger signals. We therefore propose these mediators be considered as endogenous multifunctional immune alarmins.
Some biological parameters of the bullet tuna Auxis rochei (Risso, 1810) in Tunisian waters
Creators: name: ALLAYA, Hassen
name: HATTOUR, Abdallah
name: HAJJEJ, Ghailen
name: MONIATRABELSI, MoniaTRABELSI
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2013

description: Between January and December 2010, 254 specimens of the Scombrid fish species Auxis rochei (Risso, 1810) were captured in the coastal areas of Tunisian waters. Although this species represents an important fish species among the small tunas in Tunisian fishery, its biology, namely its reproduction, has not been investigated in depth yet. During the study period, 74 females (30.7 to 42.2 cm FL) and 109 males (31.6 to 43.5 cm FL) were subjected to biological analysis. Sex- ratio was 40.43% for females. The gonado-somatic index (GSI) indicated that spawning generally occurs between July and September. The hepato-somatic index (HIS) is maximum in July with 2.99% for females, and in May with 1.90% for males. The length-weight relationships were W = 0.00138 × L3.70218 for females, W = 0.00207 × L3.59345 for males, W = 0.00164 × L3.65688 for pooled data. In the present paper some features of bullet tuna in Tunisian waters are reported in order to ensure a rational and sustainable management of this resource.
Additional file 6 of How are nature based solutions contributing to priority societal challenges surrounding human well-being in the United Kingdom: a systematic map protocol
Creators: name: Dick, Jan
name: Miller, James D.
name: Carruthers-Jones, Jonathan
name: Dobel, Anne J.
name: Carver, Steve
name: Garbutt, Angus
name: Hester, Alison
name: Hails, Rosie
name: Magreehan, Victoria
name: Quinn, Melina
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 6. Web of Science Core Collection database subscription details.
(1842) Thomas Richmond
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
THE SPATIAL NICHE OF DY NAMEN A PUMI LA (L.) AND GONOTHYRAEA LOVENI (ALLMAN) (HYDROZOA) WITHIN A FUCUS SERRATUS L COMMUNITY
Creators: name: SEED, R.
name: , R.J. O'Connor
name: BOADEN, P.J.S.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1983

Abstract
Tailored electron bunches with smooth current profiles for enhanced transformer ratios in beam-driven acceleration
Creators: name: Lemery, Francois
name: Piot, Philippe
Publisher: name: arXiv
Year: 2015
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: Collinear high-gradient ${\cal O} (GV/m)$ beam-driven wakefield methods for charged-particle acceleration could be critical to the realization of compact, cost-efficient, accelerators, e.g., in support of TeV-scale lepton colliders or multiple-user free-electron laser facilities. To make these options viable, the high accelerating fields need to be complemented with large transformer ratios $>2$, a parameter characterizing the efficiency of the energy transfer between a wakefield-exciting "drive" bunch to an accelerated "witness" bunch. While several potential current distributions have been discussed, their practical realization appears challenging due to their often discontinuous nature. In this paper we propose several alternative current profiles which are smooth which also lead to enhanced transformer ratios. We especially explore a laser-shaping method capable of generating one the suggested distributions directly out of a photoinjector and discuss a linac concept that could possible drive a dielectric accelerator.
DESCRIPTION DE DEUX NOUVELLES ESPÈCES DE LILJEBORGIIDAE DES COTES FRANÇAISES (CRUSTACEA-AMPHIPODA) : LISTRIELLA DENTIPALMA N.SP. ET LISTRIELLA SPINIFERA N.SP.
Creators: name: Dauvin, J.C.
name: Gentil, F.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1983

Abstract
Independent Trafficking of Ig- /Ig-  and  -Heavy Chain Is Facilitated by Dissociation of the B Cell Antigen Receptor Complex
Creators: name: Kim, Jin Hyang
name: Vilen, Barbara J.
name: Mueller, Heather
name: Wilson, Bridget
name: Cramer, Lorraine
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: The BCR relays extracellular signals and internalizes Ag for processing and presentation. We have previously demonstrated that ligation of the BCR destabilizes Ig-α/Ig-β (Ig-αβ) from μ-H chain (μm). In this study we report that receptor destabilization represents a physical separation of μm from Ig-αβ. Sucrose gradient fractionation localized Ig-αβ to GM1-containing lipid microdomains in the absence of μm. Confocal and electron microscopy studies revealed the colocalization of unsheathed μm with clathrin-coated vesicles. Furthermore, μm failed to associate with clathrin-coated vesicles when receptor destabilization was inhibited, suggesting that unsheathing of μm is required for clathrin-mediated endocytosis. In summary, we found that Ag stimulation physically separates Ig-αβ from μm, facilitating concomitant signal transduction and Ag delivery to the endocytic compartment.
Spatial niche partitioning in the Cellaria meadow epibiont association, northern Adriatic Sea
Creators: name: McKINNEY, Frank Ken
name: JAKLIN, Andrej
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2000

description: A diverse assemblage of foraminiferans, rhodophytes, sponges, hydroids, bryozoans, polychaete annelids, and
 ascidians lives within the dense mat formed by branches of the erect bryozoan Cellaria salicornioides that carpets a 35 m
 deep "meadow" west of Banjole Island offshore of Rovinj, Croatia. A variety of modular growth habits predominates among
 the epibionts, but almost all the most common species grow laterally by runner-like extensions. Although the depth
 distribution of each species within the mat has high variance, spatial niche partitioning is indicated because depth
 distributions of species can be discriminated statistically one from the other. Higher-level clade distribution within the mat
 generates three statistically defined zones: a shallow zone characterized by foraminiferans, rhodophytes and sponges; an
 intermediate zone characterized by hydroids, ctenostome bryozoans, annelids and ascidians; and a deep zone characterized
 by cheilostome and cyclostome bryozoans. The calcified bryozoans also show a pattern in the distribution of growth habits,
 with erect flexible colonies being on average shallowest, encrusting colonies being intermediate, and erect rigid colonies
 deepest.
Tunable negative thermal expansion related with the gradual evolution of antiferromagnetic ordering in antiperovskite manganese nitrides Ag1-xNMn3+x (0
Creators: name: Lin, J. C.
name: Tong, P.
name: Tong, W.
name: Lin, S.
name: Wang, B. S.
name: Song, W. H.
name: Zou, Y. M.
name: Sun, Y. P.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The thermal expansion and magnetic properties of antiperovskite manganese nitrides Ag1-xNMn3+x were reported. The substitution of Mn for Ag effectively broadens the temperature range of negative thermal expansion and drives it to cryogenic temperatures. As x increases, the paramagnetic (PM) to antiferromagnetic (AFM) phase transition temperature (TN) decreases. At x~0.2, the PM-AFM transition overlaps with the AFM to glass-like state transition. Above x=0.2, two new distinct magnetic transitions were observed: one occurs above room temperature from PM to ferromagnetic (FM), and the other one evolves at a lower temperature (T*) below which both AFM and FM orderings are involved. Further electron spin resonance measurement suggests that the broadened volume change near T* is closely related with the evolution of Γ5g AFM ordering.
description: 11 pages, 5 figures
BENJAMIN RUSH. An Inquiry into the Effects of Ardent Spirits Upon the Human Body and Mind. The First American Medical Work on the Effects of Alcohol.
Creators: name: Jellinek, E. M. (Elvin Morton)
Publisher: name: No Publisher Supplied
Year: 1943

description: An article published in the Quarterly Journal of Studies on Alcohol and in the volume entitled Classics of the Alcohol Literature, the primary source of many seminal articles related to Alcohol Studies.
Early Preplasma Cells Define a Tolerance Checkpoint for Autoreactive B Cells
Creators: name: Clarke, Stephen H.
name: Culton, Donna A.
name: Conway, Kara L.
name: Diz, Ramiro
name: Rutan, Jennifer
name: O'Conner, Brian P.
name: Vilen, Barbara J.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Ab-secreting plasma cells (PCs) are the effectors of humoral immunity. In this study, we describe regulation of autoreactive B cells specific for the ribonucleoprotein Smith (Sm) at an early pre-PC stage. These cells are defined by the expression of the PC marker CD138 and normal levels of CD19 and B220. They are present at a high frequency in normal mouse spleen and bone marrow, are Ag dependent, and are located predominantly along the T cell-B cell border and near bridging channels. Anti-Sm pre-PCs also occur at a high frequency in nonautoimmune mice and show additional phenotypic characteristics of PC differentiation. However, while some of these pre-PCs are Ab-secreting cells, those specific for Sm are not, indicating regulation. Consistent with this, anti-Sm pre-PCs have a higher turnover rate and higher frequency of cell death than those that do not bind Sm. Regulation of anti-Sm pre-PCs occurs upstream of the transcriptional repressor, B lymphocyte-induced maturation protein-1, expression. Regulation at this stage is overcome in autoimmune MRL/lpr mice and is accompanied by an altered B lymphocyte stimulator receptor profile. These data reveal a new B cell tolerance checkpoint that is overcome in autoimmunity.
Unilateral cranial defect bone reconstruction using 3D designing and manufacturing
Creators: name: Jindal, Prashant
name: Bhattacharya, Abhipriya
name: Singh, Major
name: Pareek, Deval
name: Watson, Jason
name: O’Connor, Rory
name: Breedon, Philip
name: Reinwald, Yvonne
name: Juneja, Mamta
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2022

description: A cranial contour defect can occur when bone is removed following direct trauma, removal of a tumor or for surgical access to the brain. These defects impair function (protection) and aesthetic contour and require a design strategy for reconstructing the defect. In principle, if the defect is unilateral (one side) then designing a form to restore the contour could be assisted by attaining a mirror image of the undamaged side of the skull. As an alternative to mirroring the undamaged skull an interpolated surface could also be generated for repairing this cranial defect. A case with a unilateral left temporal bone defect was considered for this study. A cranioplasty reconstruction was to be performed to restore the bone contour. The patient’s Computed Tomography (CT) scan (1 mm slice thickness) was saved in the raw file format Digital Imaging and Communication in Medicine (DICOM). The DICOM data was converted to a standard tesselation file (stl.) using MIMICS software (Materialise V24. Belgium). The stl. file of the skull was used to generate a 3D design of the implant using Computer-aided Design/ Computer-aided Manufacturing (CAD/CAM) software. The design was used to 3D print a base template, which could finally be used to fabricate the physical implant to restore the defect. This case explored the two techniques of mirroring and interpolation for repairing a cranial defect. A comparison of the two techniques was performed. Feedback from the surgeon suggested that interpolation provided a digitally accurate implant surface comparable to a mirrored one.
description: Transactions on Additive Manufacturing Meets Medicine, Vol. 4 No. 1 (2022): Trans. AMMM
Additional file 1 of Upadacitinib in active non-radiographic axial spondyloarthritis: 2-year data from the phase 3 SELECT-AXIS 2 study
Creators: name: Van den Bosch, Filip
name: Deodhar, Atul
name: Poddubnyy, Denis
name: Maksymowych, Walter P.
name: van der Heijde, Désirée
name: Kim, Tae-Hwan
name: Kishimoto, Mitsumasa
name: Baraliakos, Xenofon
name: Bu, Xianwei
name: Lagunes-Galindo, Ivan
name: Song, In-Ho
name: Wung, Peter
name: Kato, Koji
name: Shmagel, Anna
Publisher: name: figshare
Year: 2025
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Supplementary Material 1
THOMAS NASH. The Observations of the Elizabethan Writer Thomas Nash on Drunkenness.
Creators: name: Jellinek, E. M. (Elvin Morton)
Publisher: name: No Publisher Supplied
Year: 1943

description: An article published in the Quarterly Journal of Studies on Alcohol and in the volume entitled Classics of the Alcohol Literature, the primary source of many seminal articles related to Alcohol Studies.
(1844) Archibald Robinson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Dendritic Cells from Lupus-Prone Mice Are Defective in Repressing Immunoglobulin Secretion
Creators: name: Baldwin Jr., Albert S.
name: Vilen, Barbara J.
name: Cogswell, Patricia C.
name: Carnathan, Diane G.
name: Gilbert, Mileka M.
name: Lin, Li
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Autoimmunity results from a breakdown in tolerance mechanisms that regulate autoreactive lymphocytes. We recently showed that during innate immune responses, secretion of IL-6 by dendritic cells (DCs) maintained autoreactive B cells in an unresponsive state. In this study, we describe that TLR4-activated DCs from lupus-prone mice are defective in repressing autoantibody secretion, coincident with diminished IL-6 secretion. Reduced secretion of IL-6 by MRL/lpr DCs reflected diminished synthesis and failure to sustain IL-6 mRNA production. This occurred coincident with lack of NF-κB and AP-1 DNA binding and failure to sustain IκBα phosphorylation. Analysis of individual mice showed that some animals partially repressed Ig secretion despite reduced levels of IL-6. This suggests that in addition to IL-6, DCs secrete other soluble factor(s) that regulate autoreactive B cells. Collectively, the data show that MRL/lpr mice are defective in DC/IL-6-mediated tolerance, but that some individuals maintain the ability to repress autoantibody secretion by an alternative mechanism. The Journal of Immunology, 2007, 178: 4803–4810.
Post processing of Ti6Al4V manufactured using high power laser powder bed fusion
Creators: name: Makoana, Nkutwane Washington
name: Yadroitsava, Ina
name: Tshabalala, Lerato
name: Yadroitsev, Igor
name: Mathoho, Ipfi
name: Pityana, Sisa
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2022

description: To further increase the adoption of additive manufacturing in the industry, it is important to leverage the technology’s potential for serial production to drive down the cost of manufacturing. The use of high-powered laser beam has been envisaged as the potential technique to improve the productivity of additive manufacturing processes such as laser powder bed fusion. Since a large beam spot size is normally used at high laser power, the rougher surfaces obtained in the as-built condition can be a limitation for medical applications. As such, post processing of the parts manufactured is required to enhance the surface quality. This study investigates the effect of post processing on the surface roughness and mechanical properties of Ti6Al4V manufactured at high laser power. The samples manufactured using developed process parameters were subjected to hot isostatic press annealing and polished by centrifugal barrel finishing. The surface roughness and mechanical properties obtained are presented and discussed.
description: Transactions on Additive Manufacturing Meets Medicine, Vol. 4 No. 1 (2022): Trans. AMMM
Cutting Edge: Inflammasome Activation by Alum and Alum's Adjuvant Effect Are Mediated by NLRP3
Creators: name: Re, Fabio
name: Willingham, Stephen B.
name: Li, Hanfen
name: Ting, Jenny P.Y.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Alum is the only adjuvant approved for routine use in humans, although the basis for its adjuvanticity remains poorly understood. We have recently shown that Alum activates caspase-1 and induces secretion of mature IL-1β and IL-18. Here we show that in human and mice macrophages, alum-induced IL-1β, IL-18, and IL-33 secretion is mediated by the NLR protein NLRP3 and its adaptor ASC, but not by NLRC4. Other particulate adjuvants, such as QuilA and chitosan, induce inflammasome activation in a NLRP3-dependent fashion, suggesting that activation of the NLRP3-inflammasome may be a common mechanism of action of particulate adjuvants. Importantly, we demonstrate that antigen-specific antibody production elicited by vaccines that contain alum is significantly impaired in NLRP3-deficient mice. Our results demonstrate for the first time a role for the NLRP3-inflammasome during development of the immune response elicited by alum-enhanced vaccination. and suggest that therapeutic intervention aimed at NLRP3 may improve adjuvant efficacy.
Improved Acoustic and Adaptive Language Models for Continuous Speech Recognition
Creators: name: Rosenfeld, Ronald
name: Thayer, E
name: Mosur, R
name: Chase, L
name: Hwang, M.
name: Weide, R.
name: Huang, Xuedong
name: Alleva, Fileno
Publisher: name: Carnegie Mellon University
Year: 2023
Subjects: subject: 170203 Knowledge Representation and Machine Learning
subject: FOS: Psychology

description: We present improvements in acoustic and language modeling for large vocabulary continuous speech recognition. Two refinements to our acoustic models and a new approach to adaptive language modeling are discussed.
A new species of scale-worm (Polychaeta: Polynoidae), Lepidonotopodium atalantae sp. nov., from the East Pacific Rise at 13°N and 9°50'N
Creators: name: DESBRUYÈRES, Daniel
name: HOURDEZ, Stéphane
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2000

description: A new species of scale-worm, Lepidonotopodium atalantae, belonging to the sub-family Lepidonotopodinae
 (Polychaeta: Polynoidae) has been found in samples collected on the deep-sea hydrothermal vent sites of 9°N and 13°N on
 the East Pacific Rise. It is mainly characterized by elytra, regularly ornamented on their posterior border, and very long anal
 cirri. This is the fifth species of Lepidonotopodium, all belonging to the deep-sea hydrothermal vent fauna.
The Side-Effects of the Space Charge Field Introduced by Hollow Electron Beam in the Electron Cooler of CSRm
Creators: name: Tang, Mei-Tang
name: Yang, Xiao-Dong
name: Mao, Li-Jun
name: Li, Jie
name: Ma, Xiao-Ming
name: Yan, Tai-Lai
name: Zheng, Wen-Heng
name: Zhao, He
name: Wu, Bo
name: Wang, Geng
name: Ruan, Shuang
name: Sha, Xiao-Ping
Publisher: name: arXiv
Year: 2015
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: Electron cooler is used to improve the quality of the beam in synchrotron, however it also introduces nonlinear electromagnetic field, which cause tuneshift, tunespread and may drive resonances leading to beam loss. In this paper the tuneshift and the tunespread caused by nonlinear electromagnetic field of the hollow electron beam was investigated, and the resonance driving terms of the nonlinear electromagnetic field was analysed. The differences were presented comparing with the solid electron beam. The calculations were performed for $^{238}U^{32+}$ ions of energy 1.272MeV stored in CSRm, using the parameters given in table1. The conclusion is that in this situation nonlinear field caused by the hollow electron beam do not lead to serious resonances.
Nonmucosal Alphavirus Vaccination Stimulates a Mucosal Inductive Environment in the Peripheral Draining Lymph Node
Creators: name: Zamora, Melodie
name: Staats, Herman F.
name: Johnston, Robert E.
name: Whitmore, Alan C.
name: West, Ande
name: Nicholson, Michael G.
name: Thompson, Joseph M.
name: Iwasaki, Akiko
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The strongest mucosal immune responses are induced following mucosal Ag delivery and processing in the mucosal lymphoid tissues, and much is known regarding the immunological parameters which regulate immune induction via this pathway. Recently, experimental systems have been identified in which mucosal immune responses are induced following nonmucosal Ag delivery. One such system, footpad delivery of Venezuelan equine encephalitis virus replicon particles (VRP), led to the local production of IgA Abs directed against both expressed and codelivered Ags at multiple mucosal surfaces in mice. In contrast to the mucosal delivery pathway, little is known regarding the lymphoid structures and immunological components that are responsible for mucosal immune induction following nonmucosal delivery. In this study, we have used footpad delivery of VRP to probe the constituents of this alternative pathway for mucosal immune induction. Following nonmucosal VRP delivery, J chain-containing, polymeric IgA Abs were detected in the peripheral draining lymph node (DLN), at a time before IgA detection at mucosal surfaces. Further analysis of the VRP DLN revealed up-regulated α4β7 integrin expression on DLN B cells, expression of mucosal addressin cell adhesion molecule 1 on the DLN high endothelia venules, and production of IL-6 and CC chemokines, all characteristics of mucosal lymphoid tissues. Taken together, these results implicate the peripheral DLN as an integral component of an alternative pathway for mucosal immune induction. A further understanding of the critical immunological and viral components of this pathway may significantly improve both our knowledge of viral-induced immunity and the efficacy of viral-based vaccines.
(1840) John Gifford
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Novel system for ultrasound-assisted mixing of photopolymers with nanoparticles for additive manufacturing
Creators: name: Nordhoff, Carsten
name: Gutkelch, Dirk
name: Wiekhorst, Frank
name: Sammler, Fiona
name: Löwa, Norbert
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2022

description: Additive manufacturing is suitable to produce personalized medical phantoms and test specimens. In particular, the layer-by-layer curing of liquid photopolymers with embedded nanoparticles makes it possible to produce phantoms with defined physical properties. We have therefore developed a novel system to mix nanoparticles with photopolymers, disperse them and then feed them into an additive manufacturing system.
description: Transactions on Additive Manufacturing Meets Medicine, Vol. 4 No. S1 (2022): Trans. AMMM Supplement
Existence of Hyperbolic Calorons
Creators: name: Sibner, Lesley
name: Sibner, Robert
name: Yang, Yisong
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: Recent work of Harland shows that the $SO(3)$-symmetric, dimensionally-reduced, charge-$N$ self-dual Yang--Mills calorons on the hyperbolic space $ H^3\times S^1$ may be obtained through constructing $N$-vortex solutions of an Abelian Higgs model as in the study of Witten on multiple instantons. In this paper we establish the existence of such minimal action charge-$N$ calorons by constructing arbitrarily prescribed $N$-vortex solutions of the Witten type equations.
description: 19 pages, accepted for publication, Proceedings of Royal Society (London), Series A, 2015
Villous B Cells of the Small Intestine Are Specialized for Invariant NK T Cell Dependence
Creators: name: McPherson, Michael
name: Newberry, Rodney D.
name: Wei, Bo
name: Lobato, Lynn N.
name: Mendoza, Lesley Marie A.
name: Nguyen, Sandra L.
name: Sartor, R. Balfour
name: Schrage, Matthew
name: Fujiwara, Daisuke
name: Brewer, Sarah
name: Kronenberg, Mitchell
name: Velázquez, Peter
name: Cheng, Genhong
name: Braun, Jonathan
name: Huang, Tiffany T.
name: Arditi, Moshe
name: Turovskaya, Olga
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: B cells are important in mucosal microbial homeostasis through their well-known role in secretory IgA production and their emerging role in mucosal immunoregulation. Several specialized intraintestinal B cell compartments have been characterized, but the nature of conventional B cells in the lamina propria is poorly understood. In this study, we identify a B cell population predominantly composed of surface IgM+IgD+cells residing in villi of the small intestine and superficial lamina propria of the large intestine, but distinct from the intraepithelial compartment or organized intestinal lymphoid structures. Small intestinal (villous) B cells are diminished in genotypes that alter the strength of BCR signaling (Bruton tyrosine kinasexid, Gαi2−/−), and in mice lacking cognate BCR specificity. They are not dependent on enteric microbial sensing, because they are abundant in mice that are germfree or genetically deficient in TLR signaling. However, villous B cells are reduced in the absence of invariant NK T cells (Jα18−/− or CD1d−/− mice). These findings define a distinct population of conventional B cells in small intestinal villi, and suggest an immunologic link between CD1-restricted invariant NK T cells and this B cell population.
title: HUMAN FACTORS IN MARITIME TRANSPORTATION AND MENTAL WORKLOAD ANALYSES FOR SEAFARERS IN BRIDGE SIMULATION
Creators: name: Fan, S
Publisher: name: Liverpool John Moores University
Year: 2021

description: Since the United States Coast Guard (USCG) reported in 1993 that human factors had essentially caused approximately 80% of maritime accidents and near misses, there has been an overwhelming understanding that human factors play a significant role in a considerable number of incidents or catastrophes by triggering chain events. The work has initially documented a literature review underlining human factors in maritime accidents, mental workload study and functional Near-Infrared Spectroscopy (fNIRS) technique to imply how it can be studied for human factors in maritime transportation. It investigates how different risk factors generate an impact on different types of human-related maritime transportation accidents using a data-driven approach, and how mental workload influences neurophysiological activation and decision- making of seafarers by conducting an experimental study in bridge simulation. The results of the developed models formalise the causal interdependencies between the risk factors with human factors perspectives and highlight the implications through scenario analyses. On the other hand, the findings of the fNIRS experimental study revealed the role of the prefrontal cortex and functional connectivity in watchkeeping and collision avoidance during maritime operations. It is concluded that the understanding of risk factors contributing to human errors will help reduce the risk level or eliminate the potential hazards of ships, and provide the clue for accident investigation and generate insights for accident prevention. Also, the experimental study supports fNIRS as a valuable neuroimaging technique in realistic situations. It examines the mental workload and functional connectivity of seafarers, which helps generate insights for human performance and seafarers’ training. Finally, the inclusion of a broader range of human factors and experimental methods shows promise by associating neurophysiological experiment in the maritime section.
Finite grid instability and spectral fidelity of the electrostatic Particle-In-Cell algorithm
Creators: name: Huang, C. -K.
name: Zeng, Y.
name: Wang, Y.
name: Meyers, M. D.
name: Yi, S.
name: Albright, B. J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: The origin of the Finite Grid Instability (FGI) is studied by resolving the dynamics in the 1D electrostatic Particle-In-Cell (PIC) model in spectral domain at the single particle level and at the collective motion level. The spectral fidelity of the PIC model is contrasted with the underlying physical system or the gridless model. The systematic spectral phase and amplitude errors from the charge deposition and field interpolation are quantified for common particle shapes used in the PIC models. It is shown through such analysis and in simulations that the lack of spectral fidelity relative to the physical system due to the existence of aliased spatial modes is the major cause of the FGI in the PIC model.
Additional file 1 of “Lost in translation?” Animal research in the era of precision medicine
Creators: name: Frühwein, Hamideh
name: Paul, Norbert W.
Publisher: name: figshare
Year: 2025
Subjects: subject: Biochemistry
subject: Neuroscience
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences

description: Supplementary Material 1
(1836) Thomas Reynolds
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
3d printed trials and short-term devices
Creators: name: Marquardt, Niclas
Publisher: name: Transactions on Additive Manufacturing Meets Medicine
Year: 2022

description: Through qualified FDA approved workflows and regulations 3d printed patient specific implants like cranial plates printed from PEEK becomes reality. But besides implants also trials sizes, spacer, surgery tools or other short-term devices follows these success stories more and more often. Printed from commonly used materials in the medical industry like PPSU, PEEK and carbon fiber enhanced PEEK a brought range or application field could be covered by filament based additive manufacturing. Through DIN EN ISO 10993 approved materials in combination with the qualified Kumovis R1 printing technique medical devices for the whole orthopedic market is already possible. From joint reconstruction over spine until trauma market applications, way beyond orthosis or cutting guides, can be experienced a disruptive change. Using 3d printing to manufacture short-term devices from high performance polymers enable a huge range of benefits in terms of material as well as overall cost effectiveness. By substituting current metal-based devices to plastics like PPSU leads to a huge reduction in weight per part and therefore for whole trays of trials and instruments. Using additives like barium sulphate for x-ray visibility a complete substitution without losses in terms of performance or medical needs can be ensured. But even more important, next to natural given material benefits, are the enormous cost efficiency that could be reached throughout FFF printing also against machining or injection molding especially for small series or special sizes. Additive manufacturing even opens further advantages and develop their full potential if devices special designed for 3d printing to add functions and structures that are only possible by using an additive instead of subtractive manufacturing techniques. Bottom line multiple use short-term devices and tools applicable up to 500 sterilization cycles with 3d printing becomes more and more efficient in functionality and production costs.
description: Transactions on Additive Manufacturing Meets Medicine, Vol. 4 No. S1 (2022): Trans. AMMM Supplement