Additional file 1 of Prenatal exposures to organophosphate ester metabolite mixtures and children’s neurobehavioral outcomes in the MADRES pregnancy cohort
Creators: name: Hernandez-Castro, Ixel
name: Eckel, Sandrah P.
name: Howe, Caitlin G.
name: Niu, Zhongzheng
name: Kannan, Kurunthachalam
name: Robinson, Morgan
name: Foley, Helen B.
name: Yang, Tingyu
name: Vigil, Mario J.
name: Chen, Xinci
name: Grubbs, Brendan
name: Lerner, Deborah
name: Lurvey, Nathana
name: Al-Marayati, Laila
name: Habre, Rima
name: Dunton, Genevieve F.
name: Farzan, Shohreh F.
name: Aung, Max T.
name: Breton, Carrie V.
name: Bastain, Theresa M.
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Additional file 1: Supplemental Figure 1. Directed Acyclic Graph (DAG) of Prenatal OPE metabolites and Child Neurobehavioral Development. Supplemental Figure 2. Associations Between Urinary Prenatal OPE Metabolite Concentrations (ng/mL) and Internalizing Scores by Child Sex, Using Generalized Additive Models (N = 204). Supplemental Figure 3. Associations Between Urinary Prenatal OPE Metabolite Concentrations (ng/mL) and Externalizing Scores by Child Sex, Using Generalized Additive Models (N = 204). Supplemental Figure 4. Associations Between Urinary Prenatal OPE Metabolite Concentrations (ng/mL) and Total Problems Scores by Child Sex, Using Generalized Additive Models (N = 204). Supplemental Figure 5. Associations Between Urinary Prenatal OPE Metabolite Concentrations (ng/mL) and CBCL Composite T-Scores, Using Generalized Additive Models (N = 204). Supplemental Figure 6. Associations Between Urinary Prenatal OPE Metabolite Concentrations (ng/mL) and CBCL Composite Raw Scores Among Participants Who Reported No In-Utero Smoking, Using Generalized Additive Models (N = 199). Supplemental Figure 7. Posterior Inclusion Probabilities (PIPs) for Pairwise Interactions Between OPE Metabolites and CBCL Composite Raw Scores Using NLinteraction Method. Supplemental Figure 8. Prenatal DNBP+DIBP Exposures and Children’s Total Problems Scores by Tertiles of BCEP, Using Generalized Additive Models. Supplemental Figure 9. Prenatal OPE Urinary Metabolite Mixtures (ng/mL) and CBCL Composite T-Scores, Using BKMR (N = 204). Supplemental Figure 10. Prenatal OPE Urinary Metabolite Mixtures (ng/mL) and CBCL Composite Raw Scores Among Participants Who Reported No In-Utero Smoking, Using BKMR (N = 199). Supplemental Figure 11. Prenatal OPE Urinary Metabolite Mixtures (ng/mL) and CBCL Composite Raw Scores, Using BKMR Varying the Smoothing Parameter to b = 50. Supplemental Figure 12. Prenatal OPE Urinary Metabolite Mixtures (ng/mL) and CBCL Composite Raw Scores, Using BKMR Varying the Smoothing Parameter to b = 1000. Supplemental Figure 13. Posterior Inclusion Probabilities (PIPs) for Pairwise Interactions Between OPE Metabolites and CBCL Composite Raw Scores Using NLinteraction Method and Increasing the Threshold to 0.25. Supplemental Figure 14. Prenatal OPE Urinary Metabolite Mixtures and CBCL Composite Raw Scores, Using BKMR and Metabolites with Detect Frequency &gt;80% Only (N = 204). Supplemental Figure 15. Bivariate Associations Between Prenatal OPE Urinary Metabolite Mixtures (ng/mL) and CBCL Composite Raw Scores, Using BKMR and Metabolites with Detect Frequency &gt;80% Only (N = 204). Supplemental Table 1. Parent Compounds of OPE Metabolites Analyzed and Common Applications. Supplemental Table 2. Distribution of Specific Gravity Adjusted OPE Concentrations (ng/mL) in Urine for Maternal Participants Analyzed (N = 204) vs the Full Sample of Maternal Participants with OPEs Available (N = 426). Supplemental Table 3. Comparison of Participant Characteristics Analyzed in the Analytical Dataset (N = 204) to Subset with OPE Metabolite Concentrations Available (N = 426) and Full MADRES Participants Who Delivered Children in the Study by August 28th, 2022 (N = 774). Supplemental Table 4. Individual Associations Between Third Trimester Urinary OPE Metabolites (ng/mL) and CBCL Raw Composite Scores by Child Sex (N = 204). Supplemental Table 5. Individual Associations Between Third Trimester Urinary OPE Metabolites (ng/mL) and CBCL Composite T-Scores (N = 204). Supplemental Table 6. Individual Associations Between Third Trimester Urinary OPE Metabolites (ng/mL) and CBCL Raw Composite Scores Among Participants Who Reported No In-Utero Smoking (N = 199). Supplemental Table 7. Median Concentrations (ng/mL) of Urinary OPE Metabolites Across Published Studies.