cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Prisconnatanones A, a cytotoxic naphthoquinone from Prismatomeris connata, suppresses the proliferation of human laryngocarcinoma HEp-2 cells in vitro
Creators: name: Feng, Shixiu
name: Zhang, Min
name: Xu, Jing
name: Hu, Yinming
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Prisconnatanones A (Priscon-A) is a rare tetrahydroanthraquinone isolated from herbal Prismatomeris connate. In this study, we examine its anti-tumour activity on human laryngocarcinoma HEp-2 cells in vitro. The CCK-8 assay was performed to evaluate its cytotoxicity. Cell cycle and apoptosis were analysed using flow cytometric analysis. Here, we showed Priscon-A inhibited the proliferation of HEp-2 cells in a dose-dependent manner, and at 5 μM it almost completely inhibited cell growth. Its cytotoxicity was associated with the cell cycle arrest at G2/M phase. The Annexin V-FITC/PI binding assay showed that the cell death induced by Priscon-A was associated with apoptosis. And, western blot analysis revealed that the levels of the apoptosis protein, cleaved caspase-3, PARP, p21 and Bax protein increased, while the level of anti-apoptosis protein Bcl-2 decreased.. These data demonstrated that Priscon-A significantly inhibited HEp-2 cell growth, induced the cell cycle arrest at the G2/M phase and efficiently induced cell apoptosis. Prisconnatanones A, a cytotoxic naphthoquinone from Prismatomerisconnata, suppresses the proliferation of human laryngocarcinoma HEp-2 cells in vitro
Molasses as a new additive in papermaking: For high alphacellulose wood pulp
Creators: name: Fahmy, Tamer Y A
Publisher: name: figshare
Year: 2017
Subjects: subject: 30504 Organic Green Chemistry
subject: FOS: Chemical sciences
subject: 30304 Physical Chemistry of Materials
subject: 91210 Timber, Pulp and Paper
subject: FOS: Materials engineering

description: The present work introduces, for the first time worldwide, molasses as an additive in papermaking. The resulting paper composites exhibit greater breaking length and remarkably higher water uptake (WRV) in comparison to paper, which did not involve molasses as an additive. Previous studies, by the author and others, have shown that incorporating the cell wall microstructure of cellulose fibers with sucrose greatly enhanced the breaking length and water uptake of paper. Also, it is well established in the literature that using gums (including starch) as additives in papermaking enhances the strength of paper. Molasses contains both sucrose and gums (including starch). Molasses is a byproduct of sugar industry, which is cheaper than sucrose; and a major part of sucrose lost in sugar industry resides in molasses. Therefore, molasses was chosen as a new additive in this work. The effect of mercerization of pulp fibers before loading them with molasses is, also, studied in this work; and mercerization is shown to greatly enhance the positive effects produced by loading with molasses. Paper composites produced in this work find their use as specialty absorbent paper. The present work shows that the benefits obtained by using molasses are close to the benefits obtained in the case of using the more expensive additive sucrose.
Performance of: "I Fuck What I Like"
Creators: name: Sibisi, Noluthando Mpho
name: Matchett, Sara
name: Seane, Warona
Publisher: name: University of Cape Town
Year: 2022
Subjects: subject: 190404 Drama, Theatre and Performance Studies
subject: FOS: Arts (arts, history of arts, performing arts, music)

description: A performance piece created in partial fulfilment of the requirements for the degree of Master of Arts in Theatre and Performance at the University of Cape Town, 2021
This performance is created to complement the thesis titled: “Sexuality and cultural heritage at odds: I fuck what I like, an ode to the young queer black woman in South Africa”
ABSTRACT

I write this paper as a theatre practitioner to complete a creative research project in line with complicating and archiving queer black women’s narratives in the South African performance and literary canon. As a strategy of social reform, I aim to complicate what I argue to be an insistent narrative of queer black womanhood as emblematic of abjection by exploring the concept of queer black woman joy. I use Sara Ahmed’s The Promise of Happiness, alongside Lethabo Mailula’s theory of a tripartite erasure of queer black women, to frame what I consider to be queer black women’s cultural heritage. In search of research methods, I turn to the work of Koleka Putuma, Zanele Muholi, Athi-Patra Ruga as my artistic influences, from whom I garner multivocality, collage, ode, and play as methods for my autoethnographic explorations concerning writing, performing, and archiving joy as part of the queer black woman narrative. This research project culminates in the writing, performance, and archiving of I Fuck What I Like as an ode to the young queer black woman in South Africa.
Response of pulps of different origins to the upgrading effect of bulk added green denatured soy protein, in correlation to morphological structure & chemical composition of cellulose fibers
Creators: name: Fahmy, Tamer Y A
name: Ragab E Abou-Zeid
name: Fahmy, Yehia
Publisher: name: figshare
Year: 2017
Subjects: subject: Biochemistry
subject: 30301 Chemical Characterisation of Materials
subject: FOS: Chemical sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: 39903 Industrial Chemistry
subject: 30502 Natural Products Chemistry
subject: Organic Chemistry
subject: 30504 Organic Green Chemistry
subject: 30699 Physical Chemistry not elsewhere classified
subject: 30304 Physical Chemistry of Materials
subject: 30305 Polymerisation Mechanisms
subject: 30406 Proteins and Peptides
subject: 60310 Plant Systematics and Taxonomy
subject: FOS: Biological sciences
subject: 90301 Biomaterials
subject: FOS: Medical engineering
subject: 90499 Chemical Engineering not elsewhere classified
subject: FOS: Chemical engineering
subject: 91006 Manufacturing Processes and Technologies (excl. Textiles)
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: 91210 Timber, Pulp and Paper
subject: FOS: Materials engineering

description: Soy-protein is used, for the first time, as bulk binder in papermaking from wood pulps (hardwood and softwood pulps). Wood pulps represent the major pulps used for paper production. A green denaturing method, involving only biodegradable compounds, was found sufficient to expose the functional groups of proteins. Addition of denatured soy-protein caused a considerable increase in all strength properties of paper, at all beating degrees. The effect was highest in non-wood (for comparison) followed by hardwood and softwood pulps respectively. This could be correlated to ratio of fiber length/width, fines, and hemicellulose content of pulps. The less the ratio, and the higher the fines and hemicellulose content, the more was the increase in strength properties; due to more exposed surfaces. The outstanding effect of soy-protein was magnifying the desired opacifying effect and retention of inorganic fillers e.g. kaolin, while eliminating the loss in strength, which occurs normally due to fillers.
Sustainability of Paper & Sugar Industries via Molasses: Novel Green Nanocomposites from Upgraded Recycled Cellulose Fibers
Creators: name: Fahmy, Tamer Y A
name: Fardous Mobarak
Publisher: name: figshare
Year: 2017
Subjects: subject: 30502 Natural Products Chemistry
subject: FOS: Chemical sciences
subject: Organic Chemistry
subject: 30504 Organic Green Chemistry
subject: 30304 Physical Chemistry of Materials
subject: 90899 Food Sciences not elsewhere classified
subject: FOS: Other engineering and technologies
subject: 100703 Nanobiotechnology
subject: FOS: Nanotechnology
subject: 100708 Nanomaterials
subject: 100712 Nanoscale Characterisation
subject: 91210 Timber, Pulp and Paper
subject: FOS: Materials engineering
subject: 150106 Sustainability Accounting and Reporting
subject: FOS: Economics and business

description: The present work leads to sustainability (responsible management of resources consumption) of both paper and sugar industries. It, simultaneously, upgrades recycled waste paper (namely old newsprint) and creates a new use for molasses (an important byproduct of the sugar industry). This study introduces -for the first time world wide- a novel environmentally safe approach to upgrade recycled natural cellulose fibers (waste paper namely old newsprint), for use as specialty paper green nanocomposites suitable for several advanced purposes. The recycled cellulose fibers are upgraded by increasing their alpha cellulose content, and restoring their natural nanoporous structure, which is -normally- collapsed due to the first cycle of papermaking. Molasses is then incorporated into this restored nanoporous structure to obtain paper green nanocomposites filled with kaolin in presence of molasses. In comparison to conventionally recycled waste paper, the green paper nanocomposites -produced in this work- exhibit high dry and wet strength, and a surprisingly tremendous retention of inorganic fillers used in papermaking. This was achieved through a green nanotechnology process, where the solvent used is water (the ideal green solvent). The input and output components are renewable environmentally safe materials i.e. waste paper (cellulose fibers) and molasses (a by product of the sugar industry). The procedures used are simple physical processes conducted at room temperature rather than hazardous chemical reactions. Thus, saving energy, and decreasing the risk of chemical and thermal accidents, pollutive releases, explosions, and fires.
Physiologically based pharmacokinetic model of docetaxel and interspecies scaling: comparison of simple injection with folate receptor-targeting amphiphilic copolymer-modified liposomes
Creators: name: Lu, Xue-Feng
name: Bi, Kaishun
name: Chen, Xiaohui
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified

description: 1. To compare the disposition of docetaxel (DTX) in male/female rats after intravenous administration of simple injection and folate-poly(PEG-cyanoacrylate-co-cholesteryl cyanoacrylate)-modified liposomes utilising a physiologically based pharmacokinetic (PBPK) modelling method, and extrapolate this model to mice and humans by taking into account the interspecies differences in physiological- and chemical-specific parameters. 2. Four structural models for single organs were evaluated, and the whole-body PBPK model included artery, vein, lung, brain, heart, spleen, liver, gastrointestinal tract, kidney, muscle and remainder compartment. 3. Rats following modified liposomes administration were characterised by significant decrease in the partition coefficients for brain, spleen, liver and remainder compartment. The blood-to-plasma partition coefficient also decreased significantly, while a marked rise of partition coefficients for lung, kidney and muscle was revealed. Partition coefficient for heart was approximately 1.3-fold higher in females than males, while the decrease of intestinal clearance was revealed in females compared to males. The final model successfully characterised the time course of DTX in rats, mice and humans. 4. This PBPK model is beneficial to the prediction of the effects of DTX in different species. It also represented a platform to encompass both formulation- and sex-related effects on DTX disposition and elimination in the future.
title: 01_0046
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Nanocomposites from natural cellulose fibers incorporated with sucrose
Creators: name: Fahmy, Tamer Y A
name: Fardous Mobarak
name: Fahmy, Yehia
name: M H Fadl
name: El-Sakhawy, Mohamed
Publisher: name: figshare
Year: 2017
Subjects: subject: 30301 Chemical Characterisation of Materials
subject: FOS: Chemical sciences
subject: 30403 Characterisation of Biological Macromolecules
subject: 39999 Chemical Sciences not elsewhere classified
subject: 39903 Industrial Chemistry
subject: 30302 Nanochemistry and Supramolecular Chemistry
subject: 30502 Natural Products Chemistry
subject: Organic Chemistry
subject: 30504 Organic Green Chemistry
subject: 30699 Physical Chemistry not elsewhere classified
subject: 30304 Physical Chemistry of Materials
subject: Supramolecular Chemistry
subject: 100706 Nanofabrication, Growth and Self Assembly
subject: FOS: Nanotechnology
subject: 100707 Nanomanufacturing
subject: 100708 Nanomaterials
subject: 100712 Nanoscale Characterisation
subject: 100799 Nanotechnology not elsewhere classified
subject: 60106 Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)
subject: FOS: Biological sciences
subject: 60702 Plant Cell and Molecular Biology
subject: 60112 Structural Biology (incl. Macromolecular Modelling)

description: The present work shows for the first time worldwide that sucrose can be easily placed by simple techniques within the micropores or nanostructure of the mercerized non-dried cotton linter fibers to create a low-cost cellulose substitute. Such sucrose-containing nanocomposites find suitable use as specialty absorbent paper. Relative to the sucrose-free paper, the sucrose-containing counterparts exhibit greater breaking length and remarkably high water uptake (WRV) up to a sucrose content of 8–15% w/w. Mercerization of cotton linters before incorporating them with sucrose greatly enhanced the retention of sucrose in the prepared paper nanocomposites as compared to the case of unmercerized cotton linters. We assume that regions of the cell wall lamellae, on both sides of the sucrose spacers, are stressed during drying because the sucrose spacers hinder them to relax. This leads to a strain, which makes some microfibrils partially released and protrude out of the fiber. Thus, a sort of fiber beating takes place. We called this phenomenon incorporation beating or encapsulation beating to differentiate it from chemical and mechanical beatings, and it explains the great increase in breaking length of the paper nanocomposites prepared from the mercerized non-dried sucrose-loaded linters.
Radiation Duration in Women with Cervical Cancer Treated with Primary Chemoradiation: A Population-Based Analysis
Creators: name: I. Tergas, Ana
name: I. Neugut, Alfred
name: Chen, Ling
name: M. Burke, William
name: L. Hershman, Dawn
name: D. Wright, Jason
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Physical Sciences not elsewhere classified
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: This study examines factors associated with prolonged radiation duration and its impact on survival in women with cervical cancer treated with primary chemoradiation. Women in the National Cancer Database with stage IB2-IVA cervical cancer from 2003 to 2011 who received radiation and chemotherapy were included. Of 7209 women, who met inclusion criteria, 3401 (47.1%) and 3808 (52.8%) completed radiation in ≤ 8 and > 8 weeks, respectively. There was no overall survival difference for radiation duration ≤ 8 vs. > 8 weeks. Sensitivity analyses showed that inferior overall survival is only seen with radiation duration of > 10–12 weeks.
Resolving the extended emission of H2 on M58
Creators: name: Lopez, Ivan Ezequiel
name: Ogle, Patrick
name: Reynaldi, Victoria
Publisher: name: Zenodo
Year: 2022
Subjects: agn feedback
datacubes
h2 emission
m58

description: Spitzer mid-infrared spectral maps of the nearby galaxy M58 reveal that the physical conditions of the interstellar medium in molecular gas and star-forming regions are impacted by AGN feedback. In particular, the strong H2 extended emission in this galaxy appears to trace a large mass of jet-shocked molecular gas.
 We developed a flexible spectral-cube fitting tool to fit the infrared spectra of galaxies. We are using this tool to search for extended H2 emission in nearby galaxies so we can study the effects of AGN feedback on molecular gas and how this affects the star formation process in galaxy bulges.
High-Energy Neutrino Sources in the Infra-Red
Creators: name: Stein, Robert
Publisher: name: Zenodo
Year: 2022
Subjects: neutrinos
multi-messenger astronomy

description: Astrophysical neutrino sources were first discovered by IceCube in 2013, and there has since been an ongoing search to find the origin of these neutrinos. Neutrino detections are now published in real-time in the form of public alerts, enabling electromagnetic follow-up. In recent years, neutrino follow-up campaigns by the Zwicky Transient Facility (ZTF) at optical wavelengths have identified two Tidal Disruption Events (TDEs) as likely neutrino sources. These TDEs both exhibited dramatic dust echoes, as seen in observations at NIR and MIR wavelengths. Searching for similar dust echoes revealed a third TDE-like flare as another likely neutrino source. I will discuss how IR can be used to identify further neutrino sources, and the prospects for a planned IR neutrino follow-up program with the upcoming WINTER telescope.
Universal Model Framework: A Prime-Fractal Prompt Architecture for Unified Physics
Creators: name: Gericke, Marco
Publisher: name: Zenodo
Year: 2025
Subjects: Universal Model Framework
Prime Numbers
Fractal Geometry
Quantum Gravity
Riemann Zeta
CMB
QFT
Prime-based Cosmology
Information Physics
Emergence
Computational Metaphysics
UMF

description: This repository contains a modular, GPT-compatible framework to explore a unified physical theory that connects general relativity, quantum field theory, cosmology, and number theory. Based on the Universal Model Framework (UMF), it proposes that reality emerges from a prime-indexed, fractal information lattice—the Planck lattice—where matter, space, time, and quantum coherence are projections of structured arithmetic geometry.

The repository includes a master prompt and modular extensions to guide large language models (LLMs) in synthesizing:

Quantum coherence models on prime-modulated Sierpiński lattices

Spectral comparisons between prime Hamiltonians and Riemann Zeros

Prime-based alignment in the cosmic microwave background and void structure

A reinterpretation of gravity as an entropy gradient

The emergence of consciousness as recursive symmetry recognition

This package enables interactive, reproducible reasoning using advanced LLMs and represents an open research program bridging physics, information, and mathematics.

This project was developed by Marco Gericke, with structured assistance from a large language model (ChatGPT). All scientific concepts and conclusions were generated, verified, and interpreted by the author.

Dedicated to Peter Plichta, who envisioned the code before it could be computed.
Autophagy is required for ectoplasmic specialization assembly in sertoli cells
Creators: name: Liu, Chao
name: Wang, Hongna
name: Shang, Yongliang
name: Liu, Weixiao
name: Song, Zhenhua
name: Zhao, Haichao
name: Wang, Lina
name: Jia, Pengfei
name: Gao, Fengyi
name: Xu, Zhiliang
name: Yang, Lin
name: Gao, Fei
name: Li, Wei
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: The ectoplasmic specialization (ES) is essential for Sertoli-germ cell communication to support all phases of germ cell development and maturity. Its formation and remodeling requires rapid reorganization of the cytoskeleton. However, the molecular mechanism underlying the regulation of ES assembly is still largely unknown. Here, we show that Sertoli cell-specific disruption of autophagy influenced male mouse fertility due to the resulting disorganized seminiferous tubules and spermatozoa with malformed heads. In autophagy-deficient mouse testes, cytoskeleton structures were disordered and ES assembly was disrupted. The disorganization of the cytoskeleton structures might be caused by the accumulation of a negative cytoskeleton organization regulator, PDLIM1, and these defects could be partially rescued by Pdlim1 knockdown in autophagy-deficient Sertoli cells. Altogether, our works reveal that the degradation of PDLIM1 by autophagy in Sertoli cells is important for the proper assembly of the ES, and these findings define a novel role for autophagy in Sertoli cell-germ cell communication.
The Development and Characterisation of Porous Clay - Precipitated Calcium Carbonate
Creators: name: Halif, Norzilah Abdul
Publisher: name: figshare
Year: 2017
Subjects: subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: In this study, the development of ceramic foam utilised white clay with a combination of precipitated calcium carbonate (PCC). The ceramic foam was successfully developed using this combination after the sample was sintered at 1250 °C for 2 hours holding time. The various compositions of PCC (10.0, 12.5, 15.0, 17.5, 20.0, 22.5 and 25.0 wt.%) affected the chemical composition and compressive strength of the ceramic foam.
Fabrication of miniature components using nano
Creators: name: Zakaria, Hafizawati
Publisher: name: figshare
Year: 2017
Subjects: subject: 91201 Ceramics
subject: FOS: Materials engineering
subject: 91299 Materials Engineering not elsewhere classified
subject: Mechanical Engineering
subject: FOS: Mechanical engineering
subject: 91207 Metals and Alloy Materials
subject: 91009 Microtechnology
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: 90406 Powder and Particle Technology
subject: FOS: Chemical engineering
subject: 91011 Precision Engineering
subject: 91499 Resources Engineering and Extractive Metallurgy not elsewhere classified
subject: FOS: Environmental engineering

description: The miniaturization of components is gaining importance in many microsystem technologies such as medical technology, biotechnology and drive technology. In this study, two types nano-sized powder, metal (stainless steel 316L) and ceramic (ytria stabilized zirconia, YSZ) has been used to fabricate miniature parts by micro powder injection moulding process. Micro parts have been produced by mixing of powders with a binder system, injection, debinding and sintering process respectively. Due to the agglomeration of fine powder and environmentally hazard of organic binder, the partially water soluble binder system with surfactant addition has been used to mix with 316L or YSZ nano-powder to form feedstock. The PEG loss in water is observed by a rapidly removal period for the first 60 min immersion for micro parts. The PMMA binder is removed to 97% after the pyrolysis process at 450 ⁰C and 2.5h. Sintered ceramic and metallic parts showed that relative density about 97% of theoretical density and free defect. Hardness around 212 Hv and 1200 Hv has been achieved for fabricated micro parts using SS 316L and YSZ powders respectively.
ФОРМЫ КОНТРОЛЯ И СРЕДСТВА ОБУЧЕНИЯ НА УРОКАХ РУССКОГО ЯЗЫКА
Creators: name: Гиёсова, Василя
name: Мадаминова, Зебунисо
Publisher: name: Zenodo
Year: 2025

description: Контроль на уроке — это не просто оценка. Я часто думаю: почему слово "контроль" в школе звучит как приговор?
Autophagy is required for ectoplasmic specialization assembly in Sertoli cells
Creators: name: Liu, Chao
name: Wang, Hongna
name: Shang, Yongliang
name: Liu, Weixiao
name: Song, Zhenhua
name: Zhao, Haichao
name: Wang, Lina
name: Jia, Pengfei
name: Gao, Fengyi
name: Xu, Zhiliang
name: Yang, Lin
name: Gao, Fei
name: Li, Wei
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biophysics
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: The ectoplasmic specialization (ES) is essential for Sertoli-germ cell communication to support all phases of germ cell development and maturity. Its formation and remodeling requires rapid reorganization of the cytoskeleton. However, the molecular mechanism underlying the regulation of ES assembly is still largely unknown. Here, we show that Sertoli cell-specific disruption of autophagy influenced male mouse fertility due to the resulting disorganized seminiferous tubules and spermatozoa with malformed heads. In autophagy-deficient mouse testes, cytoskeleton structures were disordered and ES assembly was disrupted. The disorganization of the cytoskeleton structures might be caused by the accumulation of a negative cytoskeleton organization regulator, PDLIM1, and these defects could be partially rescued by Pdlim1 knockdown in autophagy-deficient Sertoli cells. Altogether, our works reveal that the degradation of PDLIM1 by autophagy in Sertoli cells is important for the proper assembly of the ES, and these findings define a novel role for autophagy in Sertoli cell-germ cell communication.
Palaeomagnetic results from Palaeogene red beds of the Chuan-Dian Fragment, southeastern margin of the Tibetan Plateau: implications for the displacement on the Xianshuihe–Xiaojiang fault systems
Creators: name: Wang, Heng
name: Yang, Zhenyu
name: Tong, Yabo
name: Gao, Liang
name: Jing, Xianqing
name: Zhang, Haifeng
Publisher: name: Taylor & Francis
Year: 2016
Subjects: Physical Sciences not elsewhere classified
Biotechnology
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Science Policy

description: The mechanism of deformation associated with the Cenozoic collision of India with Asia along the eastern boundary remains a poorly understood aspect of the tectonic evolution of the southwestern South China Block (SCB). Consequently, we carried out a palaeomagnetic investigation of Palaeogene red beds of the Dayao area of Yunnan Province in order to contribute to understanding the Palaeogene evolution of the SCB. A characteristic higher temperature magnetic component (HTC), with an unblocking temperature from 660°C to 680°C, was determined by principal component analysis (PCA), and positive fold tests indicated that the remanence was a primary magnetization. The mean direction of the HTC from the Dayao area is Ds = 27.8° Is = 33.1° κ = 64.8, α95 = 4.3° after tilt correction. Compared with other palaeomagnetic results from the SCB, our data suggest that the central part of the Chuan–Dian Fragment (CDF) experienced approximately 16.3 ± 4.7° clockwise rotation with respect to East Asia. Rotation of the CDF occurred along the left-lateral Xianshuihe–Xiaojiang Fault Systems (XSF-XJF), which exhibit an arc-shaped curve centred on the Eastern Himalayan Syntaxis. The XSF-XJF was approximated by a circle centred on a Euler pole at Lat. = 26.5° N, Lon. = 97.2° E (α95 = 0.2°), based on 11 reference points selected from the fault system. The clockwise rotation of the CDF resulted in left-lateral shearing along the XSF-XJF system, with a left-lateral displacement of ~200 km. The nature of diverse intense local deformation along the Xianshuihe-Xiaojiang left-lateral strike-slip fault systems is also discussed.
Preliminary Study: Direct Growth Carbon Nanomaterials on Metal Substrate to Improve Corrosion Resistance
Creators: name: Halif, Norzilah Abdul
Publisher: name: figshare
Year: 2017
Subjects: subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: CNMs are synthesized directly on various metal substrates by Chemical Vapor Deposition (CVD) technique without addition of any external catalyst, in reactor at temperature of 800°C. Argon with a flow rate of 200ml/min was used as a carrier gas and acetone as a carbon source. In this study, two different metals were used as metal substrate: mild steel and stainless steel 316. It was proven that the different element composition of metal substrate influenced the size and morphology of CNMs. The most suitable metal to grow CNTs was found to be stainless steel.
PARKINSONIZMNI DAVOLASHDA LEVODOPA PREPARATINING QO'LLANILISHI
Creators: name: Bahriddinova, Dilso'z
Publisher: name: Zenodo
Year: 2024

description: Parkinsonizm kasalligini paydo bo’lish sabablari va bu kasallikni davolashda qo’llaniladigan levadopa dori vositasining farmakologik ta'siri.
Effect of the river bed degradation on the vulnerability of river banks to landslides
Creators: name: Ky, Sambath
name: Martinez, Juan
name: Chhun, Soksan
Publisher: name: Academic Journal of Civil Engineering
Year: 2020

description: La dégradation du lit de la rivière et l’instabilité des berges ont augmenté dernièrement le long du bas Mékong. Cela est la conséquence de l’extraction de matériaux de la rivière et peut être de la construction de barrages hydroélectriques en amont. L’hypothèse d’une surface de rupture plane dans le lit de la rivière permet de simuler la dégradation de celui-ci et de calculer des facteurs de sécurité locaux (SFmin). Le calcul de la stabilité des berges est ensuite mené à l’aide ,de la méthode d’équilibre limite des tranches. Le niveau de la nappe phréatique dans la berge est déterminé par la méthode de Dupuit avec l’hypothèse d’un écoulement uni-directionnel, ce qui permet de déterminer les pressions intersticielles dans le sol. Les résultats montrent que les facteurs de sécurité locaux (SFmin) augmentent avec la distance au pied de la berge et diminuent avec la profondeur de la rivière. Le lit critique est celui qui produit un facteur de sécurité locale (SFmin) égale au facteur de sécurité global (SFmin(X0)) et l'angle correspondant  cr est un angle critique. Ce paramètre est utile pour évaluer le risque de projets tels que la protection des berges et l’extraction de sable.
description: Academic Journal of Civil Engineering, Vol 34 No 1 (2016): Special Issue - RUGC 2016 Liège
Low levels of graphene and graphene oxide inhibit cellular xenobiotic defense system mediated by efflux transporters
Creators: name: Liu, Su
name: Jiang, Wei
name: Wu, Bing
name: Yu, Jing
name: Yu, Haiyan
name: Zhang, Xu-Xiang
name: Torres-Duarte, Cristina
name: Cherr, Gary N.
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Low levels of graphene and graphene oxide (GO) are considered to be environmentally safe. In this study, we analyzed the potential effects of graphene and GO at relatively low concentrations on cellular xenobiotic defense system mediated by efflux transporters. The results showed that graphene (<0.5 μg/mL) and GO (<20 μg/mL) did not decrease cell viability, generate reactive oxygen species, or disrupt mitochondrial function. However, graphene and GO at the nontoxic concentrations could increase calcein-AM (CAM, an indicator of membrane ATP-binding cassette (ABC) transporter) activity) accumulation, indicating inhibition of ABC transporters’ efflux capabilities. This inhibition was observed even at 0.005 μg/mL graphene and 0.05 μg/mL GO, which are 100 times and 400 times lower than their lowest toxic concentration from cytotoxicity experiments, respectively. The inhibition of ABC transporters significantly increased the toxicity of paraquat and arsenic, known substrates of ABC transporters. The inhibition of ABC transporters was found to be based on graphene and GO damaging the plasma membrane structure and fluidity, thus altering functions of transmembrane ABC transporters. This study demonstrates that low levels of graphene and GO are not environmentally safe since they can significantly make cell more susceptible to other xenobiotics, and this chemosensitizing activity should be considered in the risk assessment of graphene and GO.
Multi-end Correlation-based Partial Discharge Location Technique for Medium Voltage Covered-conductor Lines
Creators: name: Isa, Muzamir
Publisher: name: figshare
Year: 2017
Subjects: subject: 90699 Electrical and Electronic Engineering not elsewhere classified
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In Finland, overhead covered conductors (CC) are commonly used in the medium voltage (MV) networks because the distribution loads in rural areas are not heavy and are widely distributed in the forested terrain. Such parts of the network are exposed to leaning trees and therefore partial discharging into the overhead CC frequently occurs. In this paper, a multi-end correlation-based technique for locating partial discharge (PD) sources on CC lines is presented. The theory of maximum correlation factor is used in order to find the time differences between signal arrivals at three synchronized-measuring points. This helps to solve the problem of varying parameters of the CC line that can change the propagation velocity and the problem of identifying the arrival times of the corresponding PD pulses at different measuring points. The algorithm is developed and tested using a simulated study and experimentally verified using an alternating current (ac) energized system. The Electromagnetic Transient Program-Alternative Transient Program (EMTP-ATP) is used to implement and analyze a PD monitoring system. The Discrete Wavelet Transform (DWT) is used to de-noise PD signals measured from a Rogowski coil utilized as a high frequency transducer. The noise model is added to the simulated-power network signals and then a DWT-based de-noising process is carried out. The proposed algorithm performance is evaluated by extracting the high frequency features using a windowed-standard deviation. The simulated and experimental evaluations prove that accurate PD source location can be achieved using the proposed algorithm technique. 
authorversionAMR.173.55.pdf
Creators: name: Derman, Mohd Nazree
Publisher: name: figshare
Year: 2017
Subjects: subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: This paper is study on anodising process. The mixed solution of H3PO4+CH3COOH was used to create the AAO film withcontrolled morphology. This mixed solution as anodizing electrolytes can decrease the filmdissolution rate and then increase the film formation efficiency and improve the film properties.However, optimum parameter which need for this process is very difficult to achieve because thebehaviours of the porous AAO film properties strictly influenced by anodizing process parametersuch as anodizing voltage, electrolyte temperature, acid concentration and duration of anodizingprocess. The study approach on anodizing process has been explored by using H3PO4+CH3COOHto obtain the nanostructured porous AAO film on aluminium substrate. Thus, a new hypothesis hasbeen generated to explore the relationship between anodizing parameters and substrate properties onnanostructured AAO film in microstructural and chemical properties in order to enlarge its usageespecially in electronic applications.
EGF-coated gold nanoparticles provide an efficient nano-scale delivery system for the molecular radiotherapy of EGFR-positive cancer
Creators: name: Song, Lei
name: Falzone, Nadia
name: A. Vallis, Katherine
Publisher: name: Taylor & Francis
Year: 2016
Subjects: Biophysics
Biochemistry
Space Science
Physical Sciences not elsewhere classified
Medicine
Cell Biology
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer

description: Purpose Radiolabeled antibodies and peptides hold promise for molecular radiotherapy but are often limited by a low payload resulting in inadequate delivery of radioactivity to tumour tissue and, therefore, modest therapeutic effect. We developed a facile synthetic method of radiolabeling indium-111 (111In) to epidermal growth factor (EGF)-gold nanoparticles (111In-EGF-Au NP) with a high payload. Materials and methods EGF-Au NP were prepared via an interaction between gold and the disulphide bonds of EGF and radiolabeled using 111InCl3. Targeting efficiency was investigated by quantitating internalized radioactivity and by confocal imaging following exposure of MDA-MB-468 (1.3 × 106 EGFR/cell) and MCF-7 (104 EGFR/cell) cells to Cy3-EGF-Au NP. Cytotoxicity was evaluated in clonogenic assays. Results The proportion of total administered radioactivity that was internalized by MDA-MB-468 and MCF-7 cells was 15% and 1.3%, respectively (mixing ratio of EGF:Au of 160). This differential uptake in the two cell lines was confirmed using confocal microscopy. 111In-EGF-Au NP were significantly more radiotoxic to MDA-MB-468 than MCF-7 cells with a surviving fraction of 17.1 ± 4.4% versus 89.8 ± 1.4% (p < 0.001) after exposure for 4 h. Conclusions An 111In-labeled EGF-Au nanosystem was developed. It enabled targeted delivery of a high 111In payload specifically to EGFR-positive cancer cells leading to radiotoxicity that can be exploited for molecularly targeted radiotherapy.
Two small secreted proteins from Puccinia triticina induce reduction of ß-glucoronidase transient expression in wheat isolines containing Lr9, Lr24 and Lr26
Creators: name: Segovia, Vanesa
name: Bruce, Myron
name: L. Shoup Rupp, Jessica
name: Huang, Li
name: Bakkeren, Guus
name: N. Trick, Harold
name: P. Fellers, John
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: Little is known about the molecular interaction of wheat and leaf rust (Puccinia triticina Eriks). However, genomic tools are now becoming available so that the host–pathogen interactions can be better understood. Significant efforts are being placed on understanding the secretomes of various pathogens as secreted peptides are believed to be the best candidates for avirulence effectors. In this work, a P. triticina haustorial cDNA library was evaluated for the presence of proteins containing secretion signals. Ten predicted proteins were found in the library, of which two were expressed in haustorial fractions. Three of the secreted proteins, Pt3, Pt12 and Pt27, were used in biolistic experiments to determine whether they could induce hypersensitive cell death, which is commonly observed in incompatible rust interactions with wheat leaf rust resistance genes. When Pt3 was co-bombarded with a β-glucoronidase (GUS)-expressing vector into wheat isolines with resistance genes Lr9 or Lr24, a significant reduction of GUS expression was observed, presumably due to hypersensitive cell death. In other co-bombardment experiments, Pt27 induced a significant reduction in GUS expression in the Lr26 isoline. These results suggest that Pt3 and Pt27 may function in avirulence against wheat leaf rust in resistant genotypes.
Aligned Carbon Nanofibres (CNFs) at the Graphene/Nickel Thin Film Edge
Creators: name: Halif, Norzilah Abdul
Publisher: name: figshare
Year: 2017
Subjects: subject: 91299 Materials Engineering not elsewhere classified
subject: FOS: Materials engineering

description: The growth of CNFs on graphene has been performed by chemical vapour deposition (CVD) using ferrocene as the catalyst precursor and acetone as the carbon source. Graphene film used in this study is grown on nickel (Ni) thin film, which is confirmed to be monolayer. Aligned CNTs are unintentionally obtained, however only at the graphene/Ni thin film edges.
Evolutionary based maximum power point tracking technique using differential evolution algorithm
Creators: name: Tajuddin, Mohammad Faridun Naim
Publisher: name: figshare
Year: 2017
Subjects: subject: 90699 Electrical and Electronic Engineering not elsewhere classified
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: 91305 Energy Generation, Conversion and Storage Engineering
subject: FOS: Mechanical engineering
subject: 90608 Renewable Power and Energy Systems Engineering (excl. Solar Cells)

description: This paper presents a maximum power point tracking (MPPT) technique for photovoltaic (PV) system using a modified differential evolution (DE) algorithm. The standard DE is modified to deal with dynamic objective function problem to suit with the nonlinear time-varying MPPT nature. Using this approach, a fast and accurate convergence to MPP can be achieved.
Disclosure of voluntary accounting ratios by Malaysian listed companies
Creators: name: Abdullah, Azrul
name: Ismail, Ku Nor Izah Ku
Publisher: name: figshare
Year: 2019
Subjects: subject: 140207 Financial Economics
subject: FOS: Economics and business
subject: 150103 Financial Accounting

description: Accounting ratios are believed to be of fundamental importance in financial analysis, and therefore are useful addition to financial reports. This paper examines the reporting of voluntary accounting ratio by Malaysian companies in corporate annual reports. Drawing on agency and signaling theories, this paper explores whether associations exist between company performance and voluntary disclosure of accounting ratios. In particular, associations are tested between the extent of ratio disclosure and company performance (namely profitability, liquidity, leverage, and company efficiency), size and industry. Six hypotheses are tested using data collected from 2003 annual reports of 100 Malaysian listed companies. This paper provides evidence that the extent of voluntary ratio disclosure is low; and size, industry as well as liquidity significantly influence the reporting of ratios in corporate annual reports. The implications of these findings are discussed.
Two small secreted proteins from Puccinia triticina induce reduction of ß-glucoronidase transient expression in wheat isolines containing Lr9, Lr24, and Lr26
Creators: name: Segovia, Vanesa
name: Bruce, Myron
name: L. Shoup Rupp, Jessica
name: Huang, Li
name: Bakkeren, Guus
name: N. Trick, Harold
name: P. Fellers, John
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Plant Biology
subject: Virology

description: : Little is known about the molecular interaction of wheat and leaf rust (Puccinia triticina Eriks). However, genomic tools are now becoming available so that the host-pathogen interactions can be better understood. Significant efforts are being placed on understanding the secretomes of various pathogens as secreted peptides are believed to be the best candidates for avirulence effectors. In this work, a P. triticina haustorial cDNA library was evaluated for the presence of proteins containing secretion signals. Ten predicted proteins were found in the library, of which two were expressed in haustorial fractions. Three of the secreted proteins, Pt3, Pt12, and Pt27, were used in biolistic experiments to determine whether they could induce hypersensitive cell death, which is commonly observed in incompatible rust interactions with wheat leaf rust resistance genes. When Pt3 was co-bombarded with a β-glucoronidase (GUS)-expressing vector into wheat isolines with resistance genes Lr9 or Lr24, a significant reduction of GUS expression was observed, presumably due to hypersensitive cell death. In other co-bombardment experiments, Pt27 induced a significant reduction in GUS expression in the Lr26 isoline. These results suggest that Pt3 and Pt27 may function in avirulence against wheat leaf rust in resistant genotypes.
Geometrical Shapes Impact on the Performance of ABS-Based Coreless Inductive Sensors for PD Measurement in HV Power Cables.pdf
Creators: name: Rohani, Hafizi
Publisher: name: figshare
Year: 2017
Subjects: subject: 90699 Electrical and Electronic Engineering not elsewhere classified
subject: FOS: Electrical engineering, electronic engineering, information engineering
subject: 90607 Power and Energy Systems Engineering (excl. Renewable Power)

description: In this paper, a series of investigations on sensitivityand bandwidth for four types of Rogowski coil (RC) sensorswas demonstrated. The proposed RC sensor design using acrylonitrile butadiene styrene material carries the advantages, such as lighter weight, robust, and higher temperature resistance. The prototype development first was carried out with the assistance of Solidwork 3D computer aided design software and MakerBot 2X 3D printer. Subsequently, the sensors were modeled and simulated using electromagnetic transient program alternative transient program software environment based on the lumped parameter identification. A single-end measuring technique was used to locate the PD signal on the three-phase medium voltage underground cross-link polyethylene insulated power cable with a 240-mm2 nominal area copper conductor. In order to verify the results achieved from the simulation, an experiment was carried out. This experiment was repeated concurrently for each design of the RC sensors. In order to achieve the best PD detection, the precise selection for the best sensor is paramount. In this case, the results indicated that certain geometrical shape performed better with regard to the detection of the PD signal.