title: Ð¢ÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸Ñ ÐÐµÐ½Ð³Ð¼ÑÑÐ° ÐºÐ°Ðº ÑÐ¿Ð¾ÑÐ¾Ð± Ð¿Ð¾Ð»ÑÑÐµÐ½Ð¸Ñ Ð¼ÐµÑÐ°Ð»Ð»-Ð°ÑÑÐ¸Ð½Ð½ÑÑ ÑÐ¾ÑÐ±ÐµÐ½ÑÐ¾Ð², ÑÐ¾Ð´ÐµÑÐ¶Ð°ÑÐ¸Ñ Ð¸Ð¾Ð½Ñ ÑÐµÐ´ÐºÐ¾Ð·ÐµÐ¼ÐµÐ»ÑÐ½ÑÑ Ð¼ÐµÑÐ°Ð»Ð»Ð¾Ð² Ð½Ð° ÑÐ²ÐµÑÐ´ÑÑ Ð¿Ð¾Ð´Ð»Ð¾Ð¶ÐºÐ°Ñ
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Langmuir technology as a method for producing metal-affinity sorbents containing rare-earth metal ions on solid substrates
Creators: name: ÐÐ°Ð»Ð½Ð¸Ð½Ñ, Ð¯Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2020
Subjects: ÑÐµÑ Ð½Ð¾Ð»Ð¾Ð³Ð¸Ñ ÐÐµÐ½Ð³Ð¼ÑÑÐ°
ÑÑÐµÐ°ÑÐ°ÑÑ ÑÐµÐ´ÐºÐ¾Ð·ÐµÐ¼ÐµÐ»ÑÐ½ÑÑ Ð¼ÐµÑÐ°Ð»Ð»Ð¾Ð²
ÐºÐ¾Ð»Ð»Ð°Ð¿ÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐµ Ð¼Ð¾Ð½Ð¾ÑÐ»Ð¾Ð¸
Ð¼ÐµÑÐ°Ð»Ð»-Ð°ÑÑÐ¸Ð½Ð½Ð°Ñ Ñ ÑÐ¾Ð¼Ð°ÑÐ¾Ð³ÑÐ°ÑÐ¸Ñ
ÐÐÐÐÐ Ð¼Ð¸ÑÐµÐ½Ñ
ÐÐÐÐÐ Ð¼Ð°ÑÑ-ÑÐ¿ÐµÐºÑÑÐ¾Ð¼ÐµÑÑÐ¸Ñ
Langmuir technology
rare-earth stearates
collapsed monolayers
metal affinity chromatography
MALDI target
MALDI mass spectrometry

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description: This work is devoted to the development and improvement of the method for modifying a MALDI target with metal affinity sorbents based on Langmuir monolayers containing new research objects, such as rare-earth metals (lanthanum, cerium, europium, ytterbium) for the specific isolation of chlorine-containing adducts of blood proteins. Objective: to study the possibility of modifying the MALDI target with sorbents based on lanthanum, cerium, europium, and ytterbium stearates for specific extraction of chlorine-containing protein adducts. Tasks that were solved during the study: 1. Modify the MALDI target with metal affinity sorbents based on lanthanum, cerium, europium and ytterbium stearates; 2. Investigate the resulting sorbents using various physicochemical methods; 3. Carry out metal-affinity extraction of modified globin peptides from its hydrolyzate. The work was fulfilled on the basis of Institute of Toxicology, Federal Medical-Biological Agency of Russia. The composition of each of the obtained sorbents was proved, a study of the obtained sorbents was carried out using scanning electron microscopy, energy dispersive x-ray spectroscopy and mass spectrometry. A new approach has been developed for the specific isolation of the globin adducts from 2,4- dichloro-N-chloroacetanilide from a biological sample.