cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Large Language Models for Extraction of Structured Data in Pathology
Creators: name: Grothey, Bastian
name: Tolkach, Yuri
Publisher: name: Zenodo
Year: 2024
Subjects: subject: Pathology
subject: Natural language processing
subject: Large language models

description: This repository contains a comprehensive suite of scripts designed to extract, process, analyze, and visualize structured data from pathology reports. The workflow utilizes various models and APIs, including OpenAI's GPT-4, Hugging Face's LLaMA models, and 4-bit quantized model versions provided by Ollama. Additionally, R scripts are provided for detailed statistical analysis and visualization of the extracted data.
МАҲАЛЛА ҲУҚУҚ-ТАРТИБОТ МАСКАНИ ФАОЛИЯТИНИ РЕЖАЛАШТИРИШ ВА ТАҲЛИЛ ҚИЛИШ МАҚСАДИ ҲАМДА МОҲИЯТИ
Creators: name: Кушбаков, Дилшод
Publisher: name: Zenodo
Year: 2024

description: Ушбу мақолада маҳалла ҳуқуқ-тартибот маскани фаолиятини режалаштириш ва таҳлил қилиш мақсади ҳамда моҳияти ёритилган. Шу билан бирга, маҳалла ҳуқуқ-тартибот маскани вазифаси, ишни режалаштиришда тузиладиган режа турлари ва улар асосида профилактика инспекторларининг фаолиятининг тартибга солиниши батафсил ёритилган.
Correlation between the genomic o454-nlpD region polymorphisms, virulence gene equipment and phylogenetic group of extraintestinal Escherichia coli (ExPEC) enables pathotyping irrespective of host, disease and source of isolation
Creators: name: Ewers, Christa
name: Dematheis, Flavia
name: Singamaneni, Haritha Devi
name: Nandanwar, Nishant
name: Fruth, Angelika
name: Diehl, Ines
name: Semmler, Torsten
name: Wieler, Lothar H.
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2014
Subjects: subject: MLST
subject: Escherichia coli
subject: Ecor
subject: mutS-rpoS and o454-nlpD genomic regions
subject: 610 Medizin

description: Background: The mutS-rpoS intergenic region in E. coli displays a mosaic structure which revealed pathotype specific patterns. To assess the importance of this region as a surrogate marker for the identification of highly virulent extraintestinal pathogenic E. coli (ExPEC) strains we aimed to: (i) characterize the genetic diversity of the mutS gene and the o454-nlpD genomic region among 510 E. coli strains from animals and humans; (ii) delineate associations between the polymorphism of this region and features such as phylogenetic background of E. coli, pathotype, host species, clinical condition, serogroup and virulence associated genes (VAG)s; and (iii) identify the most important VAGs for classification of the o454-nlpD region. Methods: Size variation in the o454-nlpD region was investigated by PCR amplification and sequencing. Phylogenetic relationships were assessed by Ecor- and Multilocus sequence- typing (MLST), and a comparative analysis between mutS gene phylogenetic tree obtained with RAxML and the MLST grouping method was performed. Correlation between o454-nlpD patterns and the features described above were analysed. In addition, the importance of 47 PCR-amplified ExPEC-related VAGs for classification of o454-nlpD patterns was investigated by means of Random Forest algorithm. Results: Four main structures (patterns I-IV) of the o454-nlpD region among ExPEC and commensal E. coli strains were identified. Statistical analysis showed a positive and exclusive association between pattern III and the ExPEC strains. A strong association between pattern III and either the Ecor group B2 or the sequence type complexes known to represent the phylogenetic background of highly virulent ExPEC strains (such as STC95, STC73 and STC131) was found as well. RF analyses determined five genes (csgA, malX, chuA, sit, and vat) to be suitable to predict pattern III strains. Conclusion: The significant association between pattern III and group B2 strains suggested the o454-nlpD region to be of great value in identifying highly virulent strains among the mixed population of E. coli promising to be the basis of a future typing tool for ExPEC and their gut reservoir. Furthermore, top-ranked VAGs for classification and prediction of pattern III were identified. These data are most valuable for defining ExPEC pathotype in future in vivo assays.
sj-docx-1-jpc-10.1177_21501327211030817 – Supplemental material for The Effectiveness of Telenursing for Self-Management Education on Cardiometabolic Conditions: A Pilot Project on a Remote Island of Ōsakikamijima, Japan
Creators: name: Moriyama, Michiko
name: Kazawa, Kana
name: Jahan, Yasmin
name: Ikeda, Mika
name: Mizukawa, Mariko
name: Fukuoka, Yasuko
name: Harada, Koji
name: Rahman, Md Moshiur
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified

description: Supplemental material, sj-docx-1-jpc-10.1177_21501327211030817 for The Effectiveness of Telenursing for Self-Management Education on Cardiometabolic Conditions: A Pilot Project on a Remote Island of Ōsakikamijima, Japan by Michiko Moriyama, Kana Kazawa, Yasmin Jahan, Mika Ikeda, Mariko Mizukawa, Yasuko Fukuoka, Koji Harada and Md Moshiur Rahman in Journal of Primary Care & Community Health
Notas editoriales al Cantar de Mio Cid
Creators: name: Marcos Marin, Francisco
Publisher: name: EUNSA Ediciones Universidad de Navarra
Year: 2002
Subjects: subject: Middle Ages
subject: Spanish literature
subject: Epic poetry
subject: Editing
subject: Criticism, Textual

description: Como homenaje a Fernando González Ollé se realizó esta presentación de notas y correcciones a la edición de FMM en Biblioteca Nueva, 1997, como un modo de ampliar el diálogo y abrirlo al conjunto de participantes en el homenaje, fueran autores o lectores.
Using Rapid Application Development for Software Development Projects
Creators: name: Agrawal, Suyash
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Software engineering not elsewhere classified

description: In the modern era where technology is constantly evolving, it is important to evaluate new technological tools and approaches in order to gauge their potential for adoption. Rapid Application Development (RAD) has highly evolved over the years, but it has not seen much response at the university level. Several studies show that perceptions of usability form the basis of acceptance or rejection of new tools and applications. Thus, running a usability study on a specific RAD tool coupled with autoethnographic documentation of specific development experience with that tool has the potential to encourage university faculty/staff to consider teaching/using it.
This research study seeks to understand developers' perceptions regarding the usability aspect of Mendix, a Rapid Application Development (RAD) tool. Both qualitative and quantitative approaches were employed to discover and understand the extent of perceived usefulness, ease of use and satisfaction with the tool. The results of the study presented a case for academicians on the viability of teaching RAD or using Mendix for their web application development needs. The study ultimately sought to help university faculty understand what to expect while teaching RAD to students from computing background and also help them decide if they would like to use tools like Mendix for their software development projects or continue to use specific coding languages (traditional software development) for software development projects.
Ständige Impfkommission: Aktualisierte Impfempfehlungen
Creators: name: Falkenhorst, Gerhard
name: Koch, Judith
name: Wichmann, Ole
Publisher: name: Robert Koch-Institut, Infektionsepidemiologie
Year: 2016
Subjects: subject: 610 Medizin

description: Wesentliche Änderungen betreffen die Pneumokokken-Impfung für Erwachsene ab 60 Jahren sowie für Risikogruppen. Aktualisiert wurde das Kapitel über Aufklärungspflichten vor Impfungen, neu sind Hinweise zur Schmerz- und Stressreduktion beim Impfen und zum Vorgehen bei Lieferengpässen.
Additional file 1 of Transcriptome data analysis provides insights into the conservation of Michelia lacei, a plant species with extremely small populations distributed in Yunnan province, China
Creators: name: Liu, Yang
name: Cai, Lei
name: Sun, Weibang
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Ecology

description: Additional file 1: Table S1. Detailed sampling information of seven Michelia lacei populations in Yunnan. Table S2. The CV error values of the two datasets at values of K between 2–5. Table S3. Measures of genetic diversity for 63 Michelia lacei individuals from Dataset 2. N, number of individuals in the population; π, nucleotide diversity; HO, observed heterozygosity; HE, heterozygosity within populations; FIS, inbreeding coefficient; Tajima's D, neutrality test statistics. Table S4. Genetic distances (FST values) between Michelia lacei populations based on Dataset 2. Table S5. Number of candidate SNP loci under putative selection identified by BAYESCENV and RDA; the VIF values of the four environmental factors. Table S6. GO enrichment of environment-associated genes (the combined data from the BAYESCENV and RDA analysis) in Michelia lacei (P < 0.01). Table S7. Detailed sampling information of 7 Michelia lacei populations in Yunnan. Table S8. Environmental variables used in this study and the contribution of four selected environmental factors to M. lacei distribution. Table S9. Correlation between the selected environmental factors. Fig. S1. Genetic structure obtained in Dataset 2 when K = 3. Different colors represent different genetic backgrounds. Fig. S2. Principal components analysis scatterplots based on the PCA results obtained from Datasets 2, where each point represents one plant. Fig. S3. genetic distance represented by FST/(1-FST) (a) IBE: genetic distance and environment distance (R2 = 0.519, p = 0.001), (b) IBD: genetic distance and geographical distance (R2 = 0.501, p = 0.001). Fig. S4. Population history was inferred for two Michelia lacei lineages (KM, OTHER) based on Folded SFS. The 95% confidence interval for the estimated effective population size is shown in light colors, and thick lines represent the median value. The light gray areas represent different glaciation events during the Pleistocene (XG, Xixiabangma Glaciation; LGP, Last Glaciation Period).
Hyperspectral infrared nanoimaging of organic samples based on Fourier transform infrared nanospectroscopy
Creators: name: Amenabar, Iban
name: Poly, Simon
name: Goikoetxea, Monika
name: Nuansing, Wiwat
name: Lasch, Peter
name: Hillenbrand, Rainer
Publisher: name: Robert Koch-Institut, Biologische Sicherheit
Year: 2017
Subjects: subject: 610 Medizin

description: Infrared nanospectroscopy enables novel possibilities for chemical and structural analysis of nanocomposites, biomaterials or optoelectronic devices. Here we introduce hyperspectral infrared nanoimaging based on Fourier transform infrared nanospectroscopy with a tunable bandwidth-limited laser continuum. We describe the technical implementations and present hyperspectral infrared near-field images of about 5,000 pixel, each one covering the spectral range from 1,000 to 1,900 cm−1. To verify the technique and to demonstrate its application potential, we imaged a three-component polymer blend and a melanin granule in a human hair cross-section, and demonstrate that multivariate data analysis can be applied for extracting spatially resolved chemical information. Particularly, we demonstrate that distribution and chemical interaction between the polymer components can be mapped with a spatial resolution of about 30 nm. We foresee wide application potential of hyperspectral infrared nanoimaging for valuable chemical materials characterization and quality control in various fields ranging from materials sciences to biomedicine.
Supplemental Material, sj-pdf-1-tct-10.1177_15330338211027916 - NT157 Inhibits HCC Migration via Downregulating the STAT3/Jab1 Signaling Pathway
Creators: name: Yu, SiZhe
name: Wang, Yu
name: Lv, KeJia
name: Hou, Jia
name: Li, WenYuan
name: Wang, Xiao
name: Guo, Hui
name: Wang, WenJuan
Publisher: name: SAGE Journals
Year: 2021
Subjects: Oncology and Carcinogenesis not elsewhere classified
Radiology and Organ Imaging
Biochemistry

description: Supplemental Material, sj-pdf-1-tct-10.1177_15330338211027916 for NT157 Inhibits HCC Migration via Downregulating the STAT3/Jab1 Signaling Pathway by SiZhe Yu, Yu Wang, KeJia Lv, Jia Hou, WenYuan Li, Xiao Wang, Hui Guo and WenJuan Wang in Technology in Cancer Research & Treatment
Wild African great apes as natural hosts of malaria parasites: current knowledge and research perspectives
Creators: name: Nys, Hélène Marie De
name: Löhrich, Therese
name: Wu, Doris
name: Calvignac-Spencer, Sébastien
name: Leendertz, Fabian H.
Publisher: name: Robert Koch-Institut
Year: 2017
Subjects: subject: 610 Medizin

description: Humans and African great apes (AGAs) are naturally infected with several species of closely related malaria parasites. The need to understand the origins of human malaria as well as the risk of zoonotic transmissions and emergence of new malaria strains in human populations has markedly encouraged research on great ape Plasmodium parasites. Progress in the use of non-invasive methods has rendered investigations into wild ape populations possible. Present knowledge is mainly focused on parasite diversity and phylogeny, with still large gaps to fill on malaria parasite ecology. Understanding what malaria infection means in terms of great ape health is also an important, but challenging avenue of research and has been subject to relatively few research efforts so far. This paper reviews current knowledge on African great ape malaria and identifies gaps and future research perspectives.
The many faces of Interleukin-4 in homeostasis and disease
Creators: name: Selva, Diana M Cortes
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Immunology not elsewhere classified
Microbiology not elsewhere classified

description: Intensive study of interleukin-4 for more than three decades has revealed multiple functions of this cytokine in diverse processes. Nevertheless, the wide distribution of Interleukin-4 suggests the possibility of unexplored roles. Indeed, in here we present a novel role of IL-4 for the maintenance of different populations of stromal cells in peripheral lymph nodes at homeostasis and describe a role of IL-4 in the expansion of these stromal populations following antigen challenge. In consequence, IL-4 is fundamental for mounting an appropriate humoral response to a primary immunization, and absence of this cytokine is detrimental for the development of a Type 2 response. Furthermore, we describe the role of IL-4 in the immune responses of offspring antenatally exposed to Schistosoma mansoniantigens. Diminished IL-4 production is linked to reduced cellular T and B cells responses in offspring derived from infected mothers, which is of critical relevance to understand vaccination failure. Finally, we describe the protective role of Schistosomiasis infection in atherosclerosis and propose possible mechanism that helps explain the athero-protection. This will contribute to the discovery of novel pathways inducing protection from cardiovascular disease and help to identify possible targets for novel treatments
sj-pdf-2-qhr-10.1177_10497323211028829 – Supplemental material for Theorizing Factors Mediating With the Implementation of a Patient Feedback on Safety Intervention Implemented in the Primary Care Setting
Creators: name: Beks, Hannah
name: Hernan, Andrea L.
name: Giles, Sally
name: Malakellis, Mary
name: Mc Namara, Kevin P.
name: Versace, Vincent L.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111099 Nursing not elsewhere classified
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, sj-pdf-2-qhr-10.1177_10497323211028829 for Theorizing Factors Mediating With the Implementation of a Patient Feedback on Safety Intervention Implemented in the Primary Care Setting by Hannah Beks, Andrea L. Hernan, Sally Giles, Mary Malakellis, Kevin P. Mc Namara and Vincent L. Versace in Qualitative Health Research
Prevalence and genotype distribution of hepatitis delta virus among chronic hepatitis B carriers in Central Vietnam
Creators: name: Nguyen, Hung Minh
name: Sy, Bui Tien
name: Trung, Nguyen Thanh
name: Hoan, Nghiem Xuan
name: Wedemeyer, Heiner
name: Velavan, Thirumalaisamy P.
name: Bock, Thomas
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2017
Subjects: subject: 610 Medizin

description: Hepatitis D virus (HDV) infection plays an important role in liver diseases. However, the molecular epidemiology and impact of HDV infection in chronic hepatitis B (CHB) remain uncertain in Vietnam. This cross-sectional study aimed to investigate the prevalence and genotype distribution of HDV among HBsAg-positive patients in Central Vietnam. 250 CHB patients were tested for HDV using newly established HDV-specific RT-PCR techniques. HDV genotypes were determined by direct sequencing. Of the 250 patients 25 (10%) had detectable copies of HDV viral RNA. HDV-2 was predominant (20/25; 80%) followed by HDV-1 (5/25; 20%). Proven HDV genotypes share the Asian nomenclature. Chronic hepatitis B patients with concomitant HDV-1 showed higher HBV loads as compared to HDV-2 infected patients [median log10 (HBV-DNA copies/ml): 8.5 vs. 4.4, P = 0.036]. Our findings indicate that HDV infection is highly prevalent and HDV-2 is predominant in Central Vietnam. The data will add new information to the management of HBsAg-positive patients in a highly HBV endemic region to in- or exclude HDV infection in terms of diagnostic and treatment options.
BEHAVIORAL RESPONSES TO POST-HARVEST CHALLENGES IN EAST AFRICA: LESSONS FROM FIELD EXPERIMENTS
Creators: name: Channa, Hira
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Agricultural economics

description: This dissertation consists of three different essays evaluating solutions to postharvest challenges faced by farmers in Kenya and Tanzania. In the first essay we see that demand for a new storage technology the Purdue Improved Crop Storage (PICS) bags in Western Kenya, a completely new technology for almost the entire sample, was highly elastic and that a small proportion of the population would buy at the current market price. In the second essay we find evidence that farmers, who are primarily growing for maize consumption are more concerned about food safety in maize than traders, who are willing to pay less to keep the maize safer. In the third essay in Tanzania, we find that liquidity concerns at harvest prevent farmers from optimizing maize storage and sales decisions.
sj-docx-3-mcr-10.1177_10775587211028068 – Supplemental material for How Can Implementation of a Large-Scale Patient Safety Program Strengthen Hospital Safety Culture? Lessons From a Qualitative Study of National Patient Safety Program Implementation in Two Public Hospitals in Brazil
Creators: name: Caldas, Bárbara do Nascimento
name: Portela, Margareth Crisóstomo
name: Singer, Sara Jean
name: Aveling, Emma-Louise
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, sj-docx-3-mcr-10.1177_10775587211028068 for How Can Implementation of a Large-Scale Patient Safety Program Strengthen Hospital Safety Culture? Lessons From a Qualitative Study of National Patient Safety Program Implementation in Two Public Hospitals in Brazil by Bárbara do Nascimento Caldas, Margareth Crisóstomo Portela, Sara Jean Singer and Emma-Louise Aveling in Medical Care Research and Review
The UV spectroscopy of 3-phenyl-2-propynenitrile and it's methylated derivatives
Creators: name: Jawad, Khadija M
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Physical chemistry not elsewhere classified

description: For decades there has been interest in understanding early prebiotic Earth, including its atmospheric chemistry. Saturn’s moon Titan is the only other body in our Solar System with an atmosphere thought to resemble that of early Earth’s, and for this reason it has garnered a lot of attention over the years. Much is now known about the smaller molecules present in that atmosphere, starting with the most abundant, N2 and CH4, and going up to slightly larger molecules such as cyanoacetylene and benzene. As the molecules get larger, however, so does the gap in knowledge, especially as it pertains to nitriles. This dissertation aims to add to the story of Titan’s nitriles by first characterizing a molecule thought to be the photochemical product of the reaction between cyanoacetylene and benzene, 3-phenyl-2-propyne-nitrile (PPN). The UV spectra of PPN proved immensely interesting due to the strong presence of in-plane and out-of-plane vibrations of b2 and b1 symmetry, respectively. This is possibly a result of strong vibronic coupling between several excited electronic states or Coriolis coupling between complementary b1 and b2 vibrational levels. The multi-layer extension of the multi-configuration time dependent Hartree (ML-MCTDH) algorithm was used to understand how the excited states and the vibrational levels might interact, and emission and absorption spectra were modeled and compared to the experimental spectra. The second group of molecules studied included the ortho-, meta-, and para-methyl PPN. Strong methyl rotor activity is seen in the m-methyl PPN, with some activity in the p-methyl PPN. The methyl rotor activity in the m-methyl PPN is similar to other meta-substituted toluenes, and allows us to describe the methyl rotor barrier height in both ground and excited electronic state. Additionally, in all three methylated PPNs we see evidence for strong vibronic coupling in the abundance of out-of-plane vibrations, as had been seen in PPN.
sj-docx-4-mcr-10.1177_10775587211028068 – Supplemental material for How Can Implementation of a Large-Scale Patient Safety Program Strengthen Hospital Safety Culture? Lessons From a Qualitative Study of National Patient Safety Program Implementation in Two Public Hospitals in Brazil
Creators: name: Caldas, Bárbara do Nascimento
name: Portela, Margareth Crisóstomo
name: Singer, Sara Jean
name: Aveling, Emma-Louise
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, sj-docx-4-mcr-10.1177_10775587211028068 for How Can Implementation of a Large-Scale Patient Safety Program Strengthen Hospital Safety Culture? Lessons From a Qualitative Study of National Patient Safety Program Implementation in Two Public Hospitals in Brazil by Bárbara do Nascimento Caldas, Margareth Crisóstomo Portela, Sara Jean Singer and Emma-Louise Aveling in Medical Care Research and Review
sj-docx-2-anp-10.1177_00048674211025722 – Supplemental material for Insight in nonpsychotic disorders: A new model of insight and a systematic review of measures
Creators: name: Halaj, Asala
name: Huppert, Jonathan D
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)
subject: FOS: Clinical medicine
subject: Neuroscience

description: Supplemental material, sj-docx-2-anp-10.1177_00048674211025722 for Insight in nonpsychotic disorders: A new model of insight and a systematic review of measures by Asala Halaj and Jonathan D Huppert in Australian & New Zealand Journal of Psychiatry
sj-pdf-1-chl-10.1177_17475198211032580 – Supplemental material for Homocoupling of terminal alkynes catalyzed by CuCl under solvent-free conditions
Creators: name: Xiao, Yan
name: Gao, Jiyu
name: Chen, Peng
name: Chen, Guangliang
name: Li, Zicheng
name: Huang, Wencai
Publisher: name: SAGE Journals
Year: 2021
Subjects: Materials Engineering not elsewhere classified

description: Supplemental material, sj-pdf-1-chl-10.1177_17475198211032580 for Homocoupling of terminal alkynes catalyzed by CuCl under solvent-free conditions by Yan Xiao, Jiyu Gao, Peng Chen, Guangliang Chen, Zicheng Li and Wencai Huang in Journal of Chemical Research
Additional file 2 of Glutathione Peroxidase 3 induced mitochondria-mediated apoptosis via AMPK /ERK1/2 pathway and resisted autophagy-related ferroptosis via AMPK/mTOR pathway in hyperplastic prostate
Creators: name: Li, Yan
name: Zhou, Yongying
name: Liu, Daoquan
name: Wang, Zhen
name: Qiu, Jizhang
name: Zhang, Junchao
name: Chen, Ping
name: Zeng, Guang
name: Guo, Yuming
name: Wang, Xinghuan
name: DiSanto, Michael E.
name: Zhang, Xinhua
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 2: Table S2. List of primary antibodies.
RESEARCH ON APPLYING THE SELF-PIERCE RIVETING (SPR) FOR DIE CASTING ALUMINUM ALLOYS
Creators: name: Zhao, Xuzhe
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Mechanical engineering not elsewhere classified

description: Self-pierce riveting as a relative new technology has been used by automotive industry for decades. Because of the several benefits of the SPR technique, it has been widely used for joining the similar or dissimilar materials to satisfy the light-weighting requirements of automobile. There were many researchers and automotive manufacturers that had been investigated the SPR by experiments and applied this technique to their products. The SPR was designed for joining the materials with sufficient ductility because the joining process was going to introduce the large plastic deformation on the joint button area. Die casting aluminum alloy products became more and more popular to be used for structural components. However, the casting aluminum components have relative low ductility than the wrought alloy product. The cracking problems were easy to occur during the riveting process.
In terms of the cracking issues on die casting aluminum products, an analysis was conducted in this study to investigate the influence of composition on cracking problem. And the cracking mechanism was also analyzed and summarized. Corresponding to the influence of silicon content difference and silicon morphology, heat treatment was used to modify the eutectic silicon morphology of the casting aluminum alloys to improve the rivetability. Once the silicon network was broken by the heat treatment, the rivetability of die casting aluminum was drastically increased and the cracks on joint button were also suppressed. Under the effect of heat treatment, the joint performance was tightly related to the variation of the eutectic silicon phase and the cracks on the joint button. The joint strength was obtained by shear test to investigate the influence of heat treatment and die depth. A novel cracking statistics has been generated and used to calculate the cracks on the joint button. Eventually, a comprehensive joint performance was obtained by taking into consideration of joint strength, heat treatment and die depth.
Finally, the simulation of the SPR process was conducted and analyzed by FORGE. The die depth as the variable was used to investigate the strain and fracture distribution incross-section view of the joint. In terms of the initial results of the simulation, the die cavity with various sidewall incline angles was simulated to find the optimal die cavity geometry in order to improve the rivetability of the bottom material sheet.
Additional file 1 of Glutathione Peroxidase 3 induced mitochondria-mediated apoptosis via AMPK /ERK1/2 pathway and resisted autophagy-related ferroptosis via AMPK/mTOR pathway in hyperplastic prostate
Creators: name: Li, Yan
name: Zhou, Yongying
name: Liu, Daoquan
name: Wang, Zhen
name: Qiu, Jizhang
name: Zhang, Junchao
name: Chen, Ping
name: Zeng, Guang
name: Guo, Yuming
name: Wang, Xinghuan
name: DiSanto, Michael E.
name: Zhang, Xinhua
Publisher: name: figshare
Year: 2024
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1: Table S1. Primer sequences used for qRT-PCR.
El mito del pluricentrismo desde le realidad de la traducción
Creators: name: Marcos Marin, Francisco
Publisher: name: Humanities Commons
Year: 2021
Subjects: subject: Spanish language
subject: Hispanic Americans--Social life and customs
subject: Culture--Study and teaching
subject: Journalism
subject: Germany
subject: History

description: The present work analyzes the application of the pluricentric interpretation to the Spanish language from the repercussion that this current may have to correctly interpret the complex reality of Spanish in the United States. The concept of pluricentrism is not innocent, it tries to favor certain political and economic interests and it can have serious consequences in the evolution of a linguistic community as cohesive as the Spanish-speaking one. It is an issue that affects the cultural construction of the 21st century and therefore requires research models that take into account other realities. In this work, the reality that is opposed to pluricentrism is translation and, specifically, its importance in the Spanish of the United States.
sj-docx-1-mdm-10.1177_0272989X211028236 – Supplemental material for Reference Case Methods for Expert Elicitation in Health Care Decision Making
Creators: name: Bojke, Laura
name: Soares, Marta O.
name: Claxton, Karl
name: Colson, Abigail
name: Fox, Aimée
name: Jackson, Chris
name: Jankovic, Dina
name: Morton, Alec
name: Sharples, Linda D.
name: Taylor, Andrea
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, sj-docx-1-mdm-10.1177_0272989X211028236 for Reference Case Methods for Expert Elicitation in Health Care Decision Making by Laura Bojke, Marta O. Soares, Karl Claxton, Abigail Colson, Aimée Fox, Chris Jackson, Dina Jankovic, Alec Morton, Linda D. Sharples and Andrea Taylor in Medical Decision Making
Additional file 1 of Tidal asymmetry and transition in the Singapore Strait revealed by GNSS interferometric reflectometry
Creators: name: Peng, Dongju
name: Soon, Kit Ying
name: Khoo, Victor H. S.
name: Mulder, Evert
name: Wong, Poh Weng
name: Hill, Emma M.
Publisher: name: figshare
Year: 2024
Subjects: subject: Environmental Sciences not elsewhere classified
subject: Astronomical and Space Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Additional file 1. Additional texts: Texts S1 to S4; additional figures: Figures S1 to S4; and additional tables: Tables S1 to S3.
Identification of Novel Substrates for AURKA and LIMK2
Creators: name: Haymour, Hanan S
Publisher: name: Purdue University Graduate School
Year: 2021
Subjects: Biochemistry and cell biology not elsewhere classified

description: LIMK2 is a serine/threonine/tyrosine kinase that promotes tumor cell invasion and metastasis by phosphorylating cell proteins and altering their functions. There is a need to find tumor-specific substrates for LIMK2 in order to understand the downstream pathway of these substrates, their function, and how they are regulated by LIMK2. Recently, our labrotory identified LIMK2 as an excellent target for curing castration-resistant prostate cancer (CRPC). In this study, we identify two novel substrates for LIMK2 in CRPC: speckle-type POZ protein (SPOP), and Y-box binding protein-1 (YBX1). While LIMK2 negatively regulates SPOP, it positively regulates YBX1 − both by phosphorylation using in-vitro kinase assays. A study in our labrotory also proved that LIMK2 regulates Aurora A kinase (AURKA), where AURKA directly phosphorylates LIMK2. AURKA is a serine/threonine kinase that regulates cell cycle during mitosis; it is known to be upregulated, with uncontrolled activity, in many types of cancer, including prostate cancer. It is therefore important to identify new substrates for AURKA, especially in light of reported lethality in early embryonic mice, in association with AURKA-knockout. In other words, targeting AURKA directly may cause severe toxicity, a finding that has prevented direct inhibitors from passing Phase II clinical trials. In this study, we also identified SPOP and YBX1 as direct substrates for AURKA. Our results confirm what we know about the LIMK2/AURKA relationship: that AURKA negatively regulates SPOP and positively regulates YBX1. Targeting LIMK2 and AURKA indirectly through SPOP, YBX1 and its other substrates holds tremendous therapeutic potential in treating prostate cancer. With this, we open the door for researches to investigate the direct phosphorylation of SPOP and YBX1 in other types of cancer cells known to have overexpression in SPOP and/or YBX1.
Physical health-related quality of life in relation to metabolic health and obesity among men and women in Germany
Creators: name: Truthmann, Julia
name: Mensink, Gert
name: Bosy-Westphal, Anja
name: Hapke, Ulfert
name: Scheidt-Nave, Christa
name: Schienkiewitz, Anja
Publisher: name: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung
Year: 2017
Subjects: subject: Germany
subject: SF-36
subject: Comorbidities
subject: DEGS1
subject: Lifestyle
subject: Metabolically healthy obesity
subject: Physical component summary
subject: Sex
subject: Socio-economic status
subject: 610 Medizin

description: Background: This study examined sex-specific differences in physical health-related quality of life (HRQoL) across subgroups of metabolic health and obesity. We specifically asked whether (1) obesity is related to lower HRQoL independent of metabolic health status and potential confounders, and (2) whether associations are similar in men and women. Methods: We used cross-sectional data from the German Health Interview and Examination Survey 2008–11. Physical HRQoL was measured using the Short Form-36 version 2 physical component summary (PCS) score. Based on harmonized ATPIII criteria for the definition of the metabolic health and a body mass index ≥ 30 kg/m2 to define obesity, individuals were classified as metabolically healthy non-obese (MHNO), metabolically unhealthy non-obese (MUNO), metabolically healthy obese (MHO), and metabolically unhealthy obese (MUO). Sex-specific analyses including multivariable linear regression analyses were based on PCS as the dependent variable, metabolic health and obesity category as the independent variable with three categories and MHNO as the reference, and age, education, lifestyle and comorbidities as confounders. Results: This study included 6860 participants (3298 men, 3562 women). Compared to MHNO, all other metabolic health and obesity categories had significantly lower PCS in both sexes. As reflected by the beta coefficients [95% confidence interval] from bivariable linear regression models, a significant inverse association with PCS was strongest for MUO (men: −7.0 [−8.2; −5.8]; women: −9.0 [−10.2; −7.9]), intermediate for MUNO (men: −4.2 [−5.3; −3.1]; women: −5.6 [−6.8; −4.4]) and least pronounced for MHO (men: −2.2 [−3.6; −0.8]; women −3.9 [−5.4; −2.5]). Differences in relation to MHNO remained statistically significant for all groups after adjusting for confounders, but decreased in particular for MUNO (men:–1.3 [−2.3; −0.3]; women: −1.5 [−2.7; −0.3]. Conclusions: Obesity was significantly related to lower physical HRQoL, independent of metabolic health status. Potential confounders including age, educational status, health-related behaviors, and comorbidities explained parts of the inverse relationship. Associations were evident in both sexes and consistently more pronounced among women than men.
sj-docx-2-mdm-10.1177_0272989X211028236 – Supplemental material for Reference Case Methods for Expert Elicitation in Health Care Decision Making
Creators: name: Bojke, Laura
name: Soares, Marta O.
name: Claxton, Karl
name: Colson, Abigail
name: Fox, Aimée
name: Jackson, Chris
name: Jankovic, Dina
name: Morton, Alec
name: Sharples, Linda D.
name: Taylor, Andrea
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111799 Public Health and Health Services not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, sj-docx-2-mdm-10.1177_0272989X211028236 for Reference Case Methods for Expert Elicitation in Health Care Decision Making by Laura Bojke, Marta O. Soares, Karl Claxton, Abigail Colson, Aimée Fox, Chris Jackson, Dina Jankovic, Alec Morton, Linda D. Sharples and Andrea Taylor in Medical Decision Making
Decreased emergence of HIV-1 drug resistance mutations in a cohort of Ugandan women initiating option B+ for PMTCT
Creators: name: Machnowska, Patrycja
name: Hauser, Andrea
name: Meixenberger, Karolin
name: Altmann, Britta
name: Bannert, Norbert
name: Rempis, Eva
name: Schnack, Alexandra
name: Decker, Sarah
name: Braun, Vera
name: Busingye, Priscilla
name: Rubaihayo, John
name: Harms, Gundel
name: Theuring, Stefanie
Publisher: name: Robert Koch-Institut, Infektionskrankheiten / Erreger
Year: 2017
Subjects: subject: 610 Medizin

description: Background: Since 2012, WHO guidelines for the prevention of mother-to-child transmission (PMTCT) of HIV-1 in resource-limited settings recommend the initiation of lifelong antiretroviral combination therapy (cART) for all pregnant HIV-1 positive women independent of CD4 count and WHO clinical stage (Option B+). However, long-term outcomes regarding development of drug resistance are lacking until now. Therefore, we analysed the emergence of drug resistance mutations (DRMs) in women initiating Option B+ in Fort Portal, Uganda, at 12 and 18 months postpartum (ppm). Methods and findings: 124 HIV-1 positive pregnant women were enrolled within antenatal care services in Fort Portal, Uganda. Blood samples were collected at the first visit prior starting Option B+ and postpartum at week six, month six, 12 and 18. Viral load was determined by real-time RT-PCR. An RT-PCR covering resistance associated positions in the protease and reverse transcriptase HIV-1 genomic region was performed. PCR-positive samples at 12/18 ppm and respective baseline samples were analysed by next generation sequencing regarding HIV-1 drug resistant variants including low-frequency variants. Furthermore, vertical transmission of HIV-1 was analysed. 49/124 (39.5%) women were included into the DRM analysis. Virological failure, defined as >1000 copies HIV-1 RNA/ml, was observed in three and seven women at 12 and 18 ppm, respectively. Sequences were obtained for three and six of these. In total, DRMs were detected in 3/49 (6.1%) women. Two women displayed dual-class resistance against all recommended first-line regimen drugs. Of 49 mother-infant-pairs no infant was HIV-1 positive at 12 or 18 ppm. Conclusion: Our findings suggest that the WHO-recommended Option B+ for PMTCT is effective in a cohort of Ugandan HIV-1 positive pregnant women with regard to the low selection rate of DRMs and vertical transmission. Therefore, these results are encouraging for other countries considering the implementation of lifelong cART for all pregnant HIV-1 positive women.
sj-docx-1-trr-10.1177_03611981211026304 – Supplemental material for Examining Customers’ Critical Acceptance Factors toward Ridepooling Services
Creators: name: Werth, Oliver
name: Sonneberg, Marc-Oliver
name: Leyerer, Max
name: Breitner, Michael H.
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 120599 Urban and Regional Planning not elsewhere classified
subject: FOS: Social and economic geography

description: Supplemental material, sj-docx-1-trr-10.1177_03611981211026304 for Examining Customers’ Critical Acceptance Factors toward Ridepooling Services by Oliver Werth, Marc-Oliver Sonneberg, Max Leyerer and Michael H. Breitner in Transportation Research Record
online supplementary file 1 - Supplemental material for Constitutions and Gender Equality in Chile and Argentina
Creators: name: Lambert, Priscilla
name: Scribner, Druscilla
Publisher: name: SAGE Journals
Year: 2021
Subjects: subject: 160607 International Relations
subject: FOS: Political science

description: Supplemental material, online supplementary file 1, for Constitutions and Gender Equality in Chile and Argentina by Priscilla Lambert and Druscilla Scribner in Journal of Politics in Latin America
Additional file 1 of Sex-specific innate immunity and ageing in long-lived fresh water turtles (Kinosternon flavescens: Kinosternidae)
Creators: name: Bronikowski, Anne M.
name: Hedrick, Ashley R.
name: Kutz, Greta A.
name: Holden, Kaitlyn G.
name: Reinke, Beth
name: Iverson, John B.
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1.
El Exento De El Abuso Hecho A Mi Un Case Study En Carne Propia, La Teoria Universal de Salud Mental
Creators: name: Martin Ignacio Sanjurjo Isla
Publisher: name: Mental Health For The Humane
Year: 2024
Subjects: Abuso sexual infantil
Abuso intrafamiliar
Abuso crónico
Revictimización
Trata sexual infantil
Orientación LGBTIQ+
Persecución y discriminación
Riesgo de trata sexual
Abandono y falta de respaldo
Diagnóstico incorrecto
Acoso sexual
Tácticas de DARVO
Maltrato psicológico
Manipulación emocional
Conductas de control
Suicidio intentado
Institucionalización traumática
Abuso sexual en instituciones
Revictimización en instituciones
Diagnóstico de esquizofrenia paranoide
Impacto psicológico en víctimas de abuso sexual
Rehabilitación neuropsicológica en el maltrato infantil

description: El presente caso de estudio se centra en la experiencia de un individuo que ha sufrido abuso sexual infantil crónico por parte de su padre biológico, abuso que comenzó desde los 5 años hasta los 18.5 años actuales. El abuso incluyó violaciones, actos de profanación sexual, golpizas físicas severas y sometimiento extremo. Además, el individuo sufrió bullying, discriminación y amenazas de secuestro por su orientación LGBTIQ+. Luego de la separación de su padre, el individuo mantuvo una relación tóxica con un amigo durante 9 años, lo que llevó a intentos de suicidio y una institucionalización traumática. Posteriormente, el individuo fue revictimiado en una institución psiquiátrica y diagnosticado erróneamente con esquizofrenia paranoide. Recientemente, ha sufrido acoso sexual explícito por parte de un adulto. A lo largo de su historia, ha experimentado constantes abandonos y falta de respaldo por parte de allegados y profesionales.
Additional file 1 of Organochlorine pesticides and risk of papillary thyroid cancer in U.S. military personnel: a nested case-control study
Creators: name: Rusiecki, Jennifer A.
name: McAdam, Jordan
name: Denic-Roberts, Hristina
name: Sjodin, Andreas
name: Davis, Mark
name: Jones, Richard
name: Hoang, Thanh D.
name: Ward, Mary H.
name: Ma, Shuangge
name: Zhang, Yawei
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Supplementary Material 1.
AN APPLICATION OF COGNITIVE LOAD THEORY: ASSESSMENT OF STUDENT PILOT PERFORMANCE
Creators: name: Dillman, Brian G
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Educational psychology

description: Pilot training and certification have largely remained the same since the Practical Test Standards (PTS) were issued more than twenty years ago by the Federal Aviation Administration (FAA). Within the last several years, the general aviation training sector has acquired the capability to collect and analyze digital data from certain training aircraft. With the implementation of digital information analysis, a more accurate picture of the capabilities of student pilots is possible. These advancements could be used by flight instructors in the assessment process of flight students. With the inclusion of digital data from the aircraft, the cognitive load necessary to make an accurate assessment of a student’s performance could be affected, ideally in a positive manner. Cognitive load researchers typically focus on three aspects to enhance the likelihood of success in learning or task completion. There are three techniques to reduce cognitive load: (a) reduce extraneous load, (b) manage intrinsic load, and (c) optimize germane load (Young, Cate, O’Sullivan, & Irby, 2016). The current research project focused on the impact to the cognitive load of flight instructors who were presented with digital information retrieved from an airplane during their assessment of a student pilot’s aircraft landing competence, endorsement readiness for initial solo, the willingness of the instructor to mentor the student, and how well they liked the student pilot. The study found that a digital condition, when presented alone, created extraneous cognitive load and did not enable flight instructors to accurately rate student landing performance. Additionally, flight instructors were not able to use a combined digital + traditional condition to accurately assess student landing performance. When student performance was on the extreme (i.e. ‘poor’ and ‘good’), flight instructors were better able to determine whether or not a student was ready for a solo endorsement, but instructors did have difficulty distinguishing an ‘average’ student from a ‘good’ performing student. Lastly, all of the conditions presented failed to provide the proper visualizations to allow participants to make assessments of their willingness to mentor the students, and participants indicated that they did not like the students presented with the digital condition. Digital visualizations from aircraft data will require careful development in order to limit the extraneous load and reduce the intrinsic load for student flight assessment, and should be developed in collaboration with flight instructors to provide information to assist the analysis of student flight performance.
What's the 'Problem' Statement? An Investigation of Problem-based Writing in a First Year Engineering Program
Creators: name: Velazquez, Ashley J
Publisher: name: Purdue University Graduate School
Year: 2019
Subjects: Science, technology and engineering curriculum and pedagogy
Engineering practice
English as a second language
Communication studies
Applied linguistics and educational linguistics
Professional writing and journalism practice
Technical writing

description: Upon IRB approval, a corpus of 1,192 texts consisting of three assignments written by a total of 1,736 first year engineering students was compiled, and 117 pedagogical materials were collected. Using an iterative quantitative-qualitative approach to written discourse analysis, instances of formulaic language (4- and 6-word sequences) were identified in the corpus; formulaic language was then coded for the rhetorical functions expected in problem statements as qualitatively identified in the pedagogical materials. Additionally, three discourse-based interviews were conducted with First-year Engineering Faculty. Interview data was coded for themes of effective communication and used to triangulate the findings from the corpus analysis.