cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Synthesis and evaluation of AKR1C inhibitory properties of A-ring halogenated oestrone derivatives
Creators: name: Sinreih, Maša
name: Jójárt, Rebeka
name: Kele, Zoltán
name: Büdefeld, Tomaž
name: Paragi, Gábor
name: Mernyák, Erzsébet
name: Rižner, Tea Lanišnik
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Enzymes AKR1C regulate the action of oestrogens, androgens, and progesterone at the pre-receptor level and are also associated with chemo-resistance. The activities of these oestrone halides were investigated on recombinant AKR1C enzymes. The oestrone halides with halogen atoms at both C-2 and C-4 positions (13β-, 13α-methyl-17-keto halogen derivatives) were the most potent inhibitors of AKR1C1. The lowest IC50 values were for the 13α-epimers 2_2I,4Br and 2_2I,4Cl (IC50, 0.7 μM, 0.8 μM, respectively), both of which selectively inhibited the AKR1C1 isoform. The 13α-methyl-17-keto halogen derivatives 2_2Br and 2_4Cl were the most potent inhibitors of AKR1C2 (IC50, 1.5 μM, 1.8 μM, respectively), with high selectivity for the AKR1C2 isoform. Compound 1_2Cl,4Cl showed the best AKR1C3 inhibition, and it also inhibited AKR1C1 (Ki: AKR1C1, 0.69 μM; AKR1C3, 1.43 μM). These data show that halogenated derivatives of oestrone represent a new class of potent and selective AKR1C inhibitors as lead compounds for further optimisations.
Vergleichende Untersuchungen und Bilanzierungen von Prozessketten zur Herstellung und Nutzung von Biokohlen aus Klärschlämmen
Creators: name: Gievers, Fabian
Publisher: name: Universität Rostock, Agrar- und Umweltwissenschaftliche Fakultät, Professur Abfall und Stroffstromwirtschaft
Year: 2022
Subjects: subject: 333.7 Natural resources, energy and environment
subject: 624 Structural and Environmental Engineering

description: In dieser Dissertation wurden alternative Prozessketten zur Verwertung von Klärschlämmen mithilfe einer Ökobilanz untersucht und mit der Monoverbrennung verglichen. Die Ermittlung der Emissionsprofile für die Klärschlammbehandlung mit hydrothermale Carbonisierung (HTC) und Pyrolyse sowie für die verschiedenen Anwendungspfade der entstehenden Wertstoffe erfolgte in acht verschiedenen Szenarien. Insgesamt zeigten beide Verfahren ökologische Vorteile gegenüber der Monoverbrennung, sodass Pyrolyse und HTC potentielle Verwertungstechnologien im Rahmen einer nachhaltigen Abfallwirtschaft darstellen.
Functional analysis of 2C protein in hepatitis A virus and poliovirus genome replication,
Creators: name: Cho, Michael Wan
Publisher: name: University of Utah
Year: 2012
Subjects: Persistent Infection
Biochemical Analysis: Morphologically

description: The growth properties of hepatitis A virus (HAV) in cultured cells and the biochemical properties of two viral proteins involved in genome replication, 2C and 3Dpol, were examined. The replication of HAV, unlike that of poliovirus and other picornaviruses, was nonlytic and characterized by a protracted growth cycle which terminated in a persistent infection. Replication was sensitive to millimolar concentrations of guanidine. Rapid completion of the replication cycle of HAV subsequent to reversal of guanidine inhibition demonstrated that a major factor in the apparant slow growth of the virus was asynchrony in replication. Biochemical analysis of recombinant 2C expressed in Escherichia coli was hampered by the high toxicity of the protein, low expression level, and marked insolubility. These problems were overcome by expressing the protein in either recombinant baculovirus or vaccinia virus systems, from which adequate amounts of soluble protein could be extracted by maintaining nonionic detergents in the preparation. The detergent, however, posed a subsequent problem in purification of the protein. Preliminary data showed that poliovirus 2C binds and hydrolyzes nucleoside triphosphates (NTP). No RNA helicase activity was detected. Unexpectedly, poliovirus 3Dpol exhibited an RNA duplex unwinding activity which was dependent on chain elongation, but not hydrolysis of the gamma-phosphate of NTP. Thus, the activity exhibited by 3D$/sp[/rm pol]$ is a strand displacement reaction, rather than an RNA helicase activity. Examination of human cells expressing poliovirus 2C or 2BC by immunofluorescence and electron microscopy demonstrated that these proteins, in the absence of other viral proteins, associated with specific cytoplasmic membranes. Additionally, they induced reorganization of membranes including formation of vesicles which morphologically resembled those found in poliovirus-infected cells. 2C, but not 2BC, induced the formation of tubular membrane structures with a myelin-like arrangement in the lumen of rough endoplasmic reticulum. This property of 2C was dependent on having intact NTP binding motifs in the protein. We speculate that these membrane reorganizations play a role in viral RNA replication.
Brief an [Abraham] Abramson
Creators: name: Bernoulli, Johann
Publisher: name: [s.n.]
Year: 1784

description: 4 Zeilen Antwort von Abramson
description: von J[ohann] Bernoulli
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Februar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Comparative study of four different scavenging systems for nitrous oxide
Creators: name: Morgan, Rory Watson
Publisher: name: University of Utah
Year: 2012
Subjects: Scavenging Systems
Anesthetic Gas
Field Investigations

description: A field investigation was conducted to evaluate and compare four of the commercially available scavenging systems for nitrous oxide in a dental operatory.  In 1977, the National Institute for Occupational Safety and Health (NIOSH) recommended that no worker be exposed at time-weighted average concentrations greater than 50 part per million in a dental office per administration.  Since that time, several companies have developed scavengers to capture waste anesthetic gas.  The scavenging systems tested in this study included the "Brown," "Blue," "Porter," and the "Fraser Harlake."  The anesthetic gas analyzed in all measurements was nitrous oxide.  Twenty-minute personal air samples were taken from the dentist's breathing zone.  Air samples were collected in a Tedlar bag (50 liters) using a personal air sampling pump operating at a flow rate of 2.0 liters per minute.  The air sample was analyzed using a Wilks-Foxboro, Maran 1A Infrared Gas Analyzer.  A pair of Nitrox dosimeters was taped side by side next to the open end of the Tygon tubing to test the similarity between the dosimeters and the Miran 1A results.  The results of the study indicated that the six pairs of scavengers were not statistically different at an overall ? = 0.05.  Power calculations indicate high probability the a Type II Error resulted, since only 13 of the 30 patients (required to achieve this ?-level) were obtained.  The results suggest that, given a larger sample size and similar outcomes in the test results, there could be b difference between four of the six pairs.  The results of all four scavengers exceeded the NIOSH recommendation of 50 parts per million.  Comparisons between the Nitrox dosimeters and the bag samples showed no statistically significant difference (p > 1.10).  Also, no statistical significance was shown in the results of the paired Nitrox dosimeters ( p> 0.10).
Brief an [Johan Ray?]
Creators: name: Hotton, Petrus
Publisher: name: [s.n.]
Year: 1700

description: von [Petrus Hotton?]
description: Öffentliche Bibliothek der Universität Basel
description: Englisch
description: Verzeichnung=Description=Inventaire Februar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Studies of the biological activity of naamidine A
Creators: name: James, Robyn D.
Publisher: name: University of Utah
Year: 2012
Subjects: subject: Marine Pharmacology
subject: Cancer
subject: Sponges
subject: Physiology
subject: FOS: Biological sciences

description: Malignant cells can occur due to deregulation of growth factor cascades.  The binding of epidermal growth factor (EGF) to its receptor culminates in the activation of the MAP kinase pathway.  This pathway has been identified as a vital link between membrane-bound Ras and nuclear events and therefore has great pharmacological potential as a target of chemotherapeutic drugs.  Naamidine A is a dibenzylated 2-aminoimidazole alkaloid from the calcareous sponge Leucetta chagosensis which was reported to exhibit potent inhibition of EGF-stimulated DNA synthesis in high-throughput screens.  Proliferation inhibition data collected in a cell line transfected with the EGF receptor (EGFR) gene showed modest cytotoxicity, and preliminary in vivo data demonstrated promising squamous cell carcinoma growth inhibition.  Studies were undertaken to elucidate the molecular target(s) of naamidine A and to further investigate the mechanism of action.  Naamidine A showed a significant effect on the mitogenic response by completely halting DNA synthesis in A-431 cells after 30 h.  Also, cells examined in this time point were shown to be arrested in the G1 phase of the cell cycle.  Treatment with naamidine A also produced charges in the phosphorylation states of the extracellular signal-regulated kinases (ERKs).  These enzymes propagate the activation of several proteins, which can trigger proliferation, differentiation, or cell death.  The hypothesis of this thesis in that ERK1 and ERK2 are the primary cellular targets of naamidine A in A-431 cells.  In vitro and in-gel kinase experiments demonstrated that ERK1 is a primary molecular target for naamidine A.  In-gel data, western blotting, and notable sequence similarity to ERK1 demonstrate that ERk2 is also a primary target of naamidine A.  Treatment with naamidine A strongly induces the phosphotransferase activity of the ERK enzymes in A-431 cells.  Naamidine A is the first known small molecular to cause this effect on the ERK kinases.  This type of robust ERK signal, previously only achieved by the transfection of activated Raf of MEK, has been shown to induce and sustain increased levels of p21[CIP1] in various cell lines in the G1 phase of the cell cycle.  The increase levels of p21[CIP1] bind to and inhibit cdk2, which cannot complex with cyclin E. causing cells to arrest in late G1.
Silhouette von Karl Benjamin Lengnich und seiner Frau
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1782
Subjects: Lengnich, Karl Benjamin1743-1795
Lengnich, Eleonore

description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Februar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Brief an Joh[ann] Bernoulli
Creators: name: Lengnich, Karl Benjamin
Publisher: name: [s.n.]
Year: 1788

description: von [Carl Benjamin] Lengnich
description: Mit Spuren von einer roten Oblate
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Fertility, offspring gender, and parental mortality later in life
Creators: name: Suo, Ying
Publisher: name: University of Utah
Year: 2012
Subjects: Fertility
Longevity
Offspring gender
Parental mortality
Postreproductive mortality

description: The relationship between childbearing and postreproductive mortality has attracted attention from researchers in biology, demography, anthropology, and gerontology. Findings from this growing literature are inconsistent. In addition to the relationship between parity and mortality, some studies also explore whether the gender of children may affect parental postreproductive longevity. Similar to studies examining the association between parity and mortality, the link between offspring gender and longevity is not conclusive. Two broad types of mechanisms have been proposed to explain how reproduction may affect postreproductive maternal mortality: those that are biological and those that are socio-cultural. Most of previous studies dealt with all biological children, instead of surviving children. Moreover, studies that used contemporary data to examine these relationships are often based on developed countries. Far less is known about these relationships in developing countries.  The current study examines the number of surviving children as well as the number of surviving sons and daughters in relation to parental postreproductive mortality in China, controlling for a variety of potential confounders. Data used are based on the baseline survey of the Beijing Multidimensional Longitudinal Study on Aging (BMLSA) conducted in 1992 and mortality data collected up to 2004. Cox proportional hazards regression models are used to estimate the mortality hazard ratios. Results show that females with three to six surviving children have significantly better survival than  those with only one. Males with no surviving children have higher mortality risk, compared to males with one surviving child. More daughters are associated with lower maternal mortality. It is possible that larger social support from additional children reduces females' mortality. In addition, accumulated hormonal changes due to repeated pregnancies may protect females from some diseases. Lower levels of social control and social support attributable to children may increase mortality risk among men if they have no surviving children. Our results on the interaction between fertility and urban/rural areas show that the beneficial effects of children are more pronounced in urban females with low level of fertility in relation to rural females.
Studies on the heat labile hyaluronidase inhibitor of monkey serum
Creators: name: Wilcox, Wesley Calvin
Publisher: name: University of Utah
Year: 2012
Subjects: Monkeys

description: 1.  The nature of the rise of non-specific hyaluronidase in poliomyelitis infected monkeys was established.  2.  Animals infected with the virus of poliomyelitis by means of the gastro-intestinal  route failed to exhibit a rate in non-specific inhibition.  Those animals infected by either the intranasal or intra-cerebral routes exhibited a rise in serum inhibitors levels at or near the onset of paralysis.  3.  A possible relationship between virus antibody levels and the level of physiological inhibitor is suggested.  4.  The kinetics of the enzymic hydrolysis of hyaluroic acid was studied in some detail by means of an improved turbidimetric method.  The reaction order, enzyme-substrate dissociation constant, and the energy of activation were obtained by means of these studies.  5.  The kinetics of the inhibi
Discovery of new non-pyrimidine scaffolds as Plasmodium falciparum DHFR inhibitors by fragment-based screening
Creators: name: Hoarau, Marie
name: Vanichtanankul, Jarunee
name: Srimongkolpithak, Nitipol
name: Vitsupakorn, Danoo
name: Yuthavong, Yongyuth
name: Kamchonwongpaisan, Sumalee
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: 60506 Virology
subject: Computational Biology

description: In various malaria-endemic regions, the appearance of resistance has precluded the use of pyrimidine-based antifolate drugs. Here, a three-step fragment screening was used to identify new non-pyrimidine Plasmodium falciparum dihydrofolate reductase (PfDHFR) inhibitors. Starting from a 1163-fragment commercial library, a two-step differential scanning fluorimetry screen identified 75 primary fragment hits. Subsequent enzyme inhibition assay identified 11 fragments displaying IC50 in the 28-695 μM range and selectivity for PfDHFR. In addition to the known pyrimidine, three new anti-PfDHFR chemotypes were identified. Fragments from each chemotype were successfully co-crystallized with PfDHFR, revealing a binding in the active site, in the vicinity of catalytic residues, which was confirmed by molecular docking on all fragment hits. Finally, comparison with similar non-hit fragments provides preliminary input on available growth vectors for future drug development.
The impact of NAFTA on the U.S. labor market
Creators: name: Sunthonkhan, Duangkamol
Publisher: name: University of Utah
Year: 2012
Subjects: Free trade agreements
Impact
International economics
International trade
NAFTA
U.S. labor market

description: The effect of the North American Free Trade Agreement (NAFTA) on the U.S. labor market is particularly interesting because the employment level is a key determinant of overall economic welfare. This research investigates the impact of NAFTA tariff reductions and U.S. macroeconomic conditions on U.S. employment and wages in 21 manufacturing sectors from 1994 to 2008. The estimation results reveal that U.S. macroeconomic fluctuations dominate the effects of trade liberalization. Domestic Consumption, labor productivity, GDP, capital expenditures, and land prices contributed significantly to the U.S. labor market movement. Most of the job losses in manufacturing sectors are attributable to a decrease in capital expenditures, an increase in labor productivity and land prices, and a change in the structure of employment. Competition from unskilled Mexican labor is estimated to lower wages of U.S. unskilled labor while competition from skilled Canadian labor is estimated to reduce wages of U.S. skilled labor. However, these negative effects are offset by higher productivity of aggregate U.S. labor, causing an overall increase in U.S. wages. In addition, I observe the inverse relationship between employment and wages. A decrease in employment is associated with an increase in wages per worker. To produce a finer set of results this research combines econometric work with computable general equilibrium analysis by evaluating the success of the GTAP model in predicting the impact of NAFTA reductions on U.S. employment and wages. The model performs well in simulating both production and nonproduction wages as a result of trade liberalization. The performance of the model in simulating the absolute changes in both U.S. employment and wages is less accurate. The model was only able to account for a minuscule fraction of the variance of changes in employment and wages. This research also examines the relative factor-price convergence among NAFTA countries from 1981 to 2008. The regression results reveal that commodity prices and relative factor endowments made a significant contribution to the factor-price convergence among the U.S., Canada, and Mexico. Moreover, labor-saving productivity growth also plays a significant role in driving trends in wage-rental ratios in Canada, emphasizing the importance of innovation induced by factor scarcities.
Brief an [Johann] Bernoulli
Creators: name: Lengnich, Karl Benjamin
Publisher: name: [s.n.]
Year: 1790

description: von [Carl Benjamin] Lengnich
description: Mit Oblate
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Policy analysis: federal support for nursing research
Creators: name: Ashton, Carol Ann
Publisher: name: University of Utah
Year: 2012
Subjects: Economics
Research Support

description: As a result of nursing research, care provided by nurses in many different settings has been shown to be cost effective and the quality of care provided for clients has been enhanced.  Despite findings such as these, continuation of federal support for nursing research has emerged as a major issue.  The purpose of this study was to analyze public policy processes related to federal support for nursing research.  The major research question was, How has public policy related to nursing research evolved since the passage of the Nursing Training Amendments of 1979, P.L. 96-76?"  Study emphasis was on the processes involved and not whether policy was good or bad, or what it should or ought to be.  The design of the study was exploratory, descriptive field research.  Grounded theory methodology directed the data collection and analysis.  The sample consisted of 66 nurse and nonnurse participants from three policy-making areas:  (a) legislative branch of government, (b) executive branch, and (c) nursing special interest groups. Primary methods of data collection were ethnographic interviews and unobtrusive data from government documents; participant information files were used as secondary data sources.  Interviews were transcribed and analyzed using the computer program, Ethnograph.  Constant comparative analysis directed the data coding process and continued until conceptual and theoretical categories were developed and a core variable emerged.  The major finding of this research is the development of a substantive theory, Re-Searching:  Toward Legitimization of Care.  "Re-searching" is the core variable and accounts for the central process related to nursing research policy process.  Three concepts serve to integrate the theory:  making connections, transcending disorder, and passage.  "Toward Legitimization of Care" emerged as a consequence of the policy process.  The idea of care-related research gained beginning acceptance within the larger context of biomedical or "cure" research.  The significance for nursing is the development of a theoretical scheme to explain how the policy process has affected federal support for nursing research.  Study findings provide an explanatory-theoretical scheme that can serve as a base for hypothesis generation about the policy-making process and how nursing might influence the process to effect greater support for nursing research and research training.
Brief an [Johann] Bernoulli
Creators: name: Lengnich, Karl Benjamin
Publisher: name: [s.n.]
Year: 1785

description: von [Carl Benjamin] Lengnich
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
description: Bl. 250: Jahresrechnung für Bücher
Brief an [Gottfried Kirch]
Creators: name: Langenmantel, Hieronymus Ambrosius
Publisher: name: [s.n.]
Year: 1686

description: von Hieron. Ambros. Langenmantel
description: Öffentliche Bibliothek der Universität Basel
description: Lateinisch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Anisotropic surface features of selected phyllosilicates
Creators: name: Yin, Xihui
Publisher: name: University of Utah
Year: 2012
Subjects: Anisotropic surface features
Atomic force microscopy
AFM

description: The phyllosilicate minerals are very important in geology, agriculture, and a wide range of industries. It has been known that almost all the processes in mineral processing are significantly influenced by the surface properties of the phyllosilicates. Therefore, the objective of this research is to investigate the anisotropic surface properties of selected phyllosilicates using both experimental and theoretical methods. A new technique based on atomic force microscopy (AFM) was developed to determine the anisotropic wetting characteristics of kaolinite basal surfaces. The hydrophobicity was determined by the magnitude of the hydrophobic attraction force between a hydrophobic diamond-like-carbon (DLC) AFM tip and the kaolinite basal surfaces. The results demonstrate that the kaolinite silica face has a moderate degree of hydrophobicity, whereas the kaolinite alumina face is hydrophilic. The hydrophobicity of the kaolinite silica face is found to be weaker than the talc basal surface, which may be due to the presence of isomorphous substitutions. Using molecular dynamics simulation (MDS), it is noted that the wetting characteristics and the interfacial water structure of the silica tetrahedral surface of phyllosilicates are greatly affected by the isomorphous lattice substitution. In addition, the surface charging behaviors of chlorite basal plane surfaces and the edge surface were established as a function of pH.  It is expected that the findings from this dissertation research will provide a basis for understanding the behavior of layered silicate particles in flotation systems, leaching systems, and tailing disposal systems.
Synthesis and anti-hepatocellular carcinoma activity of aminopyridinol–sorafenib hybrids
Creators: name: Awasthi, Bhuwan Prasad
name: Chaudhary, Prakash
name: Guragain, Diwakar
name: Jee, Jun-Goo
name: Kim, Jung-Ae
name: Jeong, Byeong-Seon
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Cell Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer

description: Sorafenib is recommended as the primary therapeutic drug for patients with hepatocellular carcinoma. To discover a new compound that avoids low response rates and toxic side effects that occur in sorafenib therapy, we designed and synthesized new hybrid compounds of sorafenib and 2,4,5-trimethylpyridin-3-ols. Compound 6 was selected as the best of 24 hybrids that inhibit each of the four Raf kinases. The anti-proliferative activity of 6 in HepG2, Hep3B, and Huh7 cell lines was slightly lower than that of sorafenib. However, in H6c7 and CCD841 normal epithelial cell lines, the cytotoxicity of 6 was much lower than that of sorafenib. In addition, similar to sorafenib, compound 6 inhibited spheroid forming ability of Hep3B cells in vitro and tumour growth in a xenograft tumour model of the chick chorioallantoic membrane implanted with Huh7 cells. Compound 6 may be a promising candidate targeting hepatocellular carcinoma with low toxic side effects on normal cells.
A study of coupling two thermoacoustic lasers
Creators: name: Surathu, Rohit
Publisher: name: University of Utah
Year: 2013

description: Thermoacoustics is a field studying the effects of applying heat to particular resonator geometries, resulting in the oscillations of gas and thereby producing sound waves. This field is a rich blend of many other scientific fields: acoustics, thermodynamics, and fluid mechanics. Thermoacoustic engines work on a similar principle as traditional heat engines. The main difference between a traditional heat engine and a thermoacoustic engine is that an acoustic wave drives the thermodynamic process in the latter. These engines are easy to construct, and there are no moving parts, which reduces the mechanical wear and tear. In our case, we fabricated the simpler thermoacoustic lasers to conduct the analysis. In most previous work within this field, different designs were tested and studied for a single laser operation from which extensive experimental data sets were collected and analyzed. Design and operation of a thermoacoustic laser pair is more complicated. Even though there have been a few coupling studies, detailed information about the acoustic field of multiple thermoacoustic lasers is lacking. Hence, an effort was made to study the interaction between the sound waves by acoustically coupling two thermoacoustic lasers. The acoustic coupling was varied using 4 different configurations. First, the lasers were placed parallel to each other, with their open ends separated by a 1 m distance (0o crossing angle). Next, the sound waves of the two lasers were focused at a particular point, with their openings in proximity at a fixed crossing angle (30 or 90o). Finally, the spatial distance between the openings of the 30 and 90o crossing lasers was increased in their own respective angles. The signals were read using three different measuring devices: a sound pressure level meter, a unidirectional microphone or an omnidirectional miniature microphone. The signals read using both microphones were collected, measured, and analyzed. The results proved that coupling between two thermoacoustic lasers was strong enough to allow synchronization (mode-locking) of the sound waves in a particular frequency and phase. The output amplitude of the synchronized signal produced from coupling two thermoacoustic lasers was always less compared to the acoustic amplitude of a single laser, suggesting out-of-phase synchronization. In a few experiments, the signals from the two coupled lasers did not synchronize because of the mistuning of the natural frequencies between them. When this happened, the uncoupled signals beat with the difference in the natural frequency. The amplitude output of the beating signal was greater than that of the single laser only when the two lasers were in-phase.
Brief an [Johann Bernoulli]
Creators: name: Lambertenghi, Luigi
Publisher: name: [s.n.]
Year: 1781

description: von L[uigi] Lambertenghi
description: Öffentliche Bibliothek der Universität Basel
description: Französisch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Synthesis of novel pyrroles and fused pyrroles as antifungal and antibacterial agents
Creators: name: El-Hameed, Rania Helmy Abd
name: Sayed, Amira Ibrahim
name: Ali, Shima Mahmoud
name: Mosa, Mohamed A.
name: Khoder, Zainab M.
name: Fatahala, Samar Said
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology

description: Pyrroles and its fused forms possess antimicrobial activities, they can easily interact with biomolecules of living systems. A series of substituted pyrroles, and its fused pyrimidines and triazines forms have been synthesised, all newly synthesised compound structures were confirmed by spectroscopic analysis. Generally, the compounds inhibited growth of some important human pathogens, the best effect was given by: 2a, 3c, 4d on Gram-positive bacteria and was higher on yeast (C. albicans), by 5c on Gram-negative bacteria and by 5a then 3c on filamentous fungi (A. fumigatus and F. oxysporum). Such results present good antibacterial and antifungal potential candidates to help overcome the global problem of antibiotic resistance and opportunistic infections outbreak. Compound 3c gave the best anti-phytopathogenic effect at a 50-fold lower concentration than Kocide 2000, introducing a safe commercial candidate for agricultural use. The effect of the compounds on DNA was monitored to detect the mode of action.
Brief an Joh[ann] Theodor Jablonski
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1701

description: von Michael Lange
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Identification of histone deacetylase inhibitors with (arylidene)aminoxy scaffold active in uveal melanoma cell lines
Creators: name: Nencetti, Susanna
name: Cuffaro, Doretta
name: Nuti, Elisa
name: Ciccone, Lidia
name: Rossello, Armando
name: Fabbi, Marina
name: Ballante, Flavio
name: Ortore, Gabriella
name: Carbotti, Grazia
name: Campelli, Francesco
name: Banti, Irene
name: Gangemi, Rosaria
name: Marshall, Garland R.
name: Orlandini, Elisabetta
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: FOS: Biological sciences

description: Uveal melanoma (UM) represents an aggressive type of cancer and currently, there is no effective treatment for this metastatic disease. In the last years, histone deacetylase inhibitors (HDACIs) have been studied as a possible therapeutic treatment for UM, alone or in association with other chemotherapeutic agents. Here we synthesised a series of new HDACIs based on the SAHA scaffold bearing an (arylidene)aminoxy moiety. Their HDAC inhibitory activity was evaluated on isolated human HDAC1, 3, 6, and 8 by fluorometric assay and their binding mode in the catalytic site of HDACs was studied by molecular docking. The most promising hit was the quinoline derivative VS13, a nanomolar inhibitor of HDAC6, which exhibited a good antiproliferative effect on UM cell lines at micromolar concentration and a capability to modify the mRNA levels of HDAC target genes similar to that of SAHA.
Brief an [Johann] Bernoulli
Creators: name: Lengnich, Karl Benjamin
Publisher: name: [s.n.]
Year: 1794

description: von [Carl Benjamin] Lengnich
description: Mit Oblate
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Brief an [Johann] Bernoulli
Creators: name: Lengnich, Karl Benjamin
Publisher: name: [s.n.]
Year: 1786

description: von [Carl Benjamin] Lengnich
description: Mit Oblate
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Cyclocephala ovulum H. W. Bates 1888
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala ovulum

description: Cyclocephala ovulum H. W. Bates, 1888
Cyclocephala ovulum H. W. Bates 1888: 306 (Amazon Basin, Guatemala, Nicaragua, Panama)
Distribution. Guyana: Bodkin 1919: 215; Moore et al. 2018b: 225. Suriname: MHCN - NEW COUN- TRY RECORD (Suriname, Para, 1 km W of Zanderij, (5°27′37″N, 55°13′21″W). 5-I-2011. A. J. Hielkema. On UV/HPL in savanna forest.); NZCS. French Guiana: Moore et al. 2018b: 225. “Guianas”: Arrow 1937b: 14; Blackwelder 1944: 252. Brazil: Arrow 1937b: 14; Blackwelder 1944: 252; Moore et al. 2018b: 225. Venezuela (EO): Kirmse and Ratcliffe 2019: 153 (EO). “Amazon Basin”: H. W. Bates 1888: 306. Other: H. W. Bates 1888: 306 (Guatemala, Nicaragua, Panama); Arrow 1937b: 14 (Guatemala, Paraguay); Blackwelder 1944: 252 (Guatemala, Nicaragua, Panama, Paraguay); Endrödi 1966a: 318 (treated as an aberration of C. testacea), 1985a: 108, 146 (treated as an aberration of C. testacea); Ponchel 2011 (not mentioned); Dupuis 2016b (not mentioned); Moore et al. 2018b: 225 (Argentina, Colombia, Costa Rica, Ecuador, El Salvador, Guatemala, Honduras, Mexico, Nicaragua, Panama, Paraguay).
Note. In Endrödi (1966a: 318, 1985a: 108, 146) Cyclocephala ovulum is regarded as an aberration of C. testacea. It is reinstated as a species in Ratcliffe (2003: 180). It is noteworthy that, despite several collectors and authors being active in French Guiana, no reliable records of C. ovulum from the Guianas have been published after Blackwelder (1944: 252), even though Ratcliffe has identified Surinamese specimens from multiple locations in the first author’s collection as belonging to this species. However, C. testacea has recently been reported multiple times for French Guiana (see under that species). This likely means that either the Marowijne River between Suriname and French Guiana acts as a border for this species, or that either Surinamese or French Guianese specimens are consistently being misidentified, or that the validity of C. ovulum as a separate species is not (yet) accepted by French taxonomists. The only record for French Guiana that we are aware of is in Gruner (1971: 845), as C. testacea ab. ovulum, and in Moore et al. (2018b: 225), with the former being copied by the latter (M. Moore, pers. comm. 2018). Given the apparent overall untrustworthiness of Gruner (1971), we consider this record unreliable.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 177, DOI: 10.5281/zenodo.3678492
title: Synchronization techniques for non-ideal communication channels
title: Τεχνικές συγχρονισμού για μη ιδανικά τηλεπικοινωνιακά κανάλια
Creators: name: Ζιωγας Αλεξανδρος
Publisher: name: Technical University of Crete
Year: 2024

description: This thesis investigates synchronization techniques in non-ideal wireless communication channels, also known as wideband channels. In these channels, several non-ideal conditions occur, like, for example, multipath propagation resulting into intersymbol interference, and carrier frequency offset. Thus, in order to ensure precise symbols recovery at the receiver, we must use advanced synchronization methods. The study begins with the examination of the structure of the transmitter, highlighting the creation of the symbol packets via the transmitter’s filter. Concepts such as training symbols, square root raised cosine filter, intersymbol interference and low pass equivalent of input signal are analysed in Chapter 2. In Chapter 3, the thesis delves into the characteristics of the communication channel, exploring the scenario of multipath propagation. It emphasizes the impact of delay spread, a critical parameter in multipath channels, which introduces intersymbol interference. Chapter 4 is about the operation of the receiver. Synchronization techniques are addressed in detail, including methods for estimating and correcting the Carrier Frequency Offset (CFO) and the discrete equivalent channel. Finally, in order to counteract the channel’s effects, we implement a zero-forcing equalizer, ensuring that the overall telecommunication system approximates a simple delay.
description: Η παρούσα διπλωματική εργασία μελετά τεχνικές συγχρονισμού σε μη ιδανικά κανάλια ασύρματης επικοινωνίας, γνωστά και ως ευρυζωνικά κανάλια. Σε αυτά τα κανάλια, εμφανίζονται διάφορες μη ιδανικές συνθήκες, όπως, για παράδειγμα, το φαινόμενο πολλαπλής διόδευσης (multipath) και η διαφορά συχνότητας φορέα (carrier frequency offset). Έτσι, για να εξασφαλιστεί η ακριβής ανάκτηση των συμβόλων στον δέκτη, χρησιμοποιούνται μέθοδοι όπως ο συγχρονισμός, η εκτίμηση και η διόρθωση της διαφοράς συχνότητας φορέα, η εκτίμηση του καναλιού και η ισοστάθμισή του. Η μελέτη ξεκινά με την εξέταση της δομής του πομπού, επισημαίνοντας τη δημιουργία των πακέτων συμβόλων. Έννοιες όπως τα σύμβολα εκπαίδευσης, το φίλτρο τετραγωνικής ρίζας ανυψωμένου συνημιτόνου και το ισοδύναμο χαμηλοπερατό του σήματος εισόδου αναλύονται στο Κεφάλαιο 2. Στο Κεφάλαιο 3, η εργάσια εμβαθύνει στα χαρακτηριστικά του καναλιού επικοινωνίας, ερευνώντας το σενάριο της πολλαπλής διόδευσης. Τονίζεται ο αντίκτυπος του delay spread, μια κρίσιμη παράμετρος στα κανάλια πολλαπλής διόδευσης, η οποία εισάγει διασυμβολική παρεμβολή. Το Κεφάλαιο 4 αφορά στη λειτουργία του δέκτη. Τεχνικές συγχρονισμού αναλύονται λεπτομερώς και παρουσιάζονται μέθοδοι εκτίμησης και διόρθωσης της διαφοράς συχνότητας φορέα και του ισοδύναμου διακριτού καναλιού. Τέλος, για την αναίρεση των επιδράσεων του καναλιού, υλοποιείται ένας ισοσταθμιστής μηδενικής διασυμβολικής παρεμβολής (zero forcing equalizer), διασφαλίζοντας ότι το συνολικό τηλεπικοινωνιακό σύστημα προσεγγίζει μια απλή καθυστέρηση.
Brief an [Johann Bernoulli]
Creators: name: Langguth, Christian August
Publisher: name: [s.n.]
Year: 1787

description: von [Christian August] Langguth
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog
Cyclocephala paraflora Martinez 1978
Creators: name: Hielkema, Auke J.
name: Hielkema, Meindert A.
Publisher: name: Zenodo
Year: 2019
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Coleoptera
Dynastidae
Cyclocephala
Cyclocephala paraflora

description: Cyclocephala paraflora Martínez, 1978
Cyclocephala paraflora Martínez 1978: 12 (Brazil (NA))
Distribution. Guyana: Endrödi 1985a: 737. French Guiana: Dechambre 1979c: 165; Moore et al. 2018b: 226. Brazil (NA): Martínez 1978: 12 (NA); Dechambre 1979c: 165; Endrödi 1985a: 737; Moore et al. 2018b: 226 (NA). Other: Ponchel 2011 (not mentioned); Dupuis 2016b (not mentioned); Moore et al. 2018b: 226 (Colombia, Peru).
Note. Cyclocephala paraflora is recorded as a new country record for French Guiana by Dechambre (1979c: 165). This record is repeated in Moore et al. (2018b: 226), but the species is not mentioned by Ponchel (2011) or Dupuis (2016b). We consider the presence of this species in French Guiana in need of confirmation.
description: Published as part of Hielkema, Auke J. & Hielkema, Meindert A., 2019, An annotated checklist of the Scarabaeoidea (Insecta: Coleoptera) of the Guianas, pp. 1-306 in Insecta Mundi 732 (732) on page 177, DOI: 10.5281/zenodo.3678492
title: Memoria 2012
Creators: name: Universidad Especializada de las Américas, UDELAS
Publisher: name: Universidad Especializadas de las Américas
Year: 2019
Subjects: subject: FOS: Educational sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: 2012, es un año de orgullo institucional para la Universidad Especializada de las Américas (UDELAS). Arribamos a los 15 años de existencia de nuestra Universidad, con la satisfacción de haber logrado la acreditación universitaria.
title: Similarities and Differences in the Argumentative Characteristics of the Official Brexit Campaigns
Creators: name: Sanders, James E
Publisher: name: London School of Economics and Political Science (LSE)
Year: 2018
Subjects: subject: J Political Science
subject: JA Political science (General)
subject: JN Political institutions (Europe)

description: This paper adds to the growing empirical literature surrounding the UK's vote to leave the European Union. Specifically, a series of quantitative and qualitative textual analysis tools are implemented on a corpus consisting of the websites of Vote Leave (VL) and Britain Stronger in Europe (BSE). By breaking down argumentative text into two components, this paper attempts to characterise how the two official campaigns differ in the information they choose to convey (or “focus"), and the style by which this information is conveyed. To analyse variation in focus, a structural topic model and thematic analysis of elementary context units are conducted with the inclusion of document-level metadata. This is then compared to survey data and their potential effectiveness is considered. To study the style of information transmission, an analysis of sentiment is used to calculate sentence-level polarity scores. An unambiguous thematic divide is uncovered with BSE employing a “focussed" approach by singling out topics related to the economy, whereas VL chose a “scattershot" approach by spreading their resources across a broader range of themes. The thematic analysis uncovers little reciprocity in most major areas — a notable exception being public services, which acted as a battleground. BSE's focussed approach allowed it to target the most influential topic for the electorate, but despite this, VL's approach led to a greater targeted proportion. A sentiment analysis yields two results: (A) the variability in sentence-level polarity scores was consistent across campaigns, and (2) BSE's website had a significantly greater mean score.
Integration of reservoir simulation and geomechanics
Creators: name: Zhao, Nan
Publisher: name: University of Utah
Year: 2012
Subjects: Geomechanics
Reservoir simulation
Natural gas

description: Fluid production from tight and shale gas formations has increased significantly, and this unconventional portfolio of low-permeability reservoirs accounts for more than half of the gas produced in the United States. Stimulation and hydraulic fracturing are critical in making these systems productive, and hence it is important to understand the mechanics of the reservoir. When modeling fractured reservoirs using discrete-fracture network representation, the geomechanical effects are expected to have a significant impact on important reservoir characteristics. It has become more accepted that fracture growth, particularly in naturally fractured reservoirs with extremely low permeability, cannot be reliably represented by conventional planar representations. Characterizing the evolution of multiple, nonplanar, interconnected and possibly nonvertical hydraulic fractures requires hydraulic and mechanical characterization of the matrix, as well as existing latent or healed fracture networks. To solve these challenging problems, a reservoir simulator (Advanced Reactive Transport Simulator (ARTS)) capable of performing unconventional reservoir simulation is developed in this research work. A geomechanical model has been incorporated into the simulation framework with various coupling schemes and this model is used to understand the geomechanical effects in unconventional oil and gas recovery. This development allows ARTS to accept geomechanical information from external geomechanical simulators (soft coupling) or the solution of the geomechanical coupled problem (hard coupling). An iterative solution method of the flow and geomechanical equations has been used in implementing the hard coupling scheme. The hard coupling schemes were verified using one-dimensional and two-dimensional analytical solutions. The new reservoir simulator is applied to learn the influence of geomechanical impact on unconventional oil and gas production in a number of practical recovery scenarios. A commercial simulator called 3DEC was the geomechanical simulator used in soft coupling. In a naturally fractured reservoir, considering geomechanics may lead to an increase or decrease in production depending on the relationship between the reservoir petrophysical properties and mechanics. Combining geomechanics and flow in multiphase flow settings showed that production decrease could be caused by a combination of fracture contraction and water blockage. The concept of geomechanical coupling was illustrated with a complex naturally fractured system containing 44 fractures. Development of the generalized framework, being able to study multiphase flow reservoir processes with coupled geomechanics, and understanding of complex phenomena such as water blocks are the major outcomes from this research. These new tools will help in creating strategies for efficient and sustainable production of fluids from unconventional resources.
Brief an [Johann] Bernoulli
Creators: name: Lengnich, Karl Benjamin
Publisher: name: [s.n.]
Year: 1791

description: von [Carl Benjamin] Lengnich
description: Mit Spuren von einer Oblate
description: Öffentliche Bibliothek der Universität Basel
description: Deutsch
description: Verzeichnung=Description=Inventaire Januar 2015 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Standortverzeichnis und Briefkatalog