cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: 03_0286
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Additional file 1: of The efficacy of the traditional Chinese medicine Juanbi pill combined with methotrexate in active rheumatoid arthritis: study protocol for a randomized controlled trial
Creators: name: Wang, Qiong
name: Wang, Yi-Ru
name: Jia, Qing-Yun
name: Liu, Li
name: Xu, Chong-Qing
name: Wang, Xiao-Yun
name: Yao, Min
name: Cui, Xue-Jun
name: Shi, Qi
name: Wang, Yong-Jun
name: Liang, Qian-Qian
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: SPIRIT 2013 checklist: Recommended items to address in a clinical trial protocol and related documents. (PDF 284 kb)
Canadian National Data Services Framework: Discussion Document
Creators: name: Baker, David
name: Barsky, Eugene
name: Burpee, Jane
name: Leggott, Mark
name: Moon, Jeff
name: Sinatra, Michael
name: Spencer, Byron
name: Gerlitz, Laura
Publisher: name: Zenodo
Year: 2019
Subjects: subject: national data services
subject: research data management
subject: digital research infrastructure
subject: canada
subject: https://dictionary.casrai.org/Research_data_management
subject: https://dictionary.casrai.org/Data_management
subject: https://dictionary.casrai.org/Digital_infrastructure

description: This document is intended as a backgrounder to the 2nd NDSF Summit, and as a general discussion paper for the Canadian data management community.
description: This document was produced by the NDSF Working Group, of the Infrastructure Committee of Research Data Canada.
Reasons to be cautious about 'well-being' in economic development (and elsewhere)
Creators: name: Jenkins, Matt
Publisher: name: figshare
Year: 2017
Subjects: subject: Geography
subject: 160499 Human Geography not elsewhere classified
subject: FOS: Social and economic geography

description: This is the submitted version of a paper published here, http://www.inderscienceonline.com/doi/pdf/10.1504/IJHD.2016.079592, in the International Journal of Happiness and Development, in early 2016.
Official statistic-making as a social practice: the UK 'Measuring National Well-being' programme
Creators: name: Jenkins, Matt
Publisher: name: figshare
Year: 2017
Subjects: subject: Geography
subject: 160403 Social and Cultural Geography
subject: FOS: Social and economic geography

description: This is my thesis, including the creative appendix at the end. It was accepted as doctorate-worthy in early 2016.
Response and injury of the human leg for axial impact durations applicable to automotive intrusion and underbody blast environments
Creators: name: Bailey, Ann M.
name: Perry, Brandon J.
name: Salzar, Robert S.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: Similar lower extremity injuries occur in both military vehicle underbody blast and automotive intrusion events despite the drastic differences in acceleration, velocity, and load duration. Understanding human leg response to variations in load rate and boundary condition is imperative to assessment of injury using anthropomorphic test devices (ATDs). Two axial impact test series were performed using post-mortem human surrogate legs, varying load rates and using ‘fixed’ and translational proximal tibia boundaries. Corridors were developed for a 50th percentile male for five loading rates ranging from 0.3 to 12 kN/ms. Calculated leg stiffness ranged from 700 to 1600 N/mm, and foot and ankle compression at peak force accounted for greater than 75% of lower leg compression. Injuries included calcaneus, talus, pilon, and malleolar fractures. Results indicated a duration-dependence of fracture force, which has major implications for the validity of existing injury criteria and the future design of ATD legs.
title: 01_0389
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Photocrosslinked tyramine-substituted hyaluronate hydrogels with tunable mechanical properties improve immediate tissue-hydrogel interfacial strength in articular cartilage
Creators: name: Donnelly, Patrick E.
name: Chen, Tony
name: Finch, Anthony
name: Brial, Caroline
name: Maher, Suzanne A.
name: Torzilli, Peter A.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Articular cartilage lacks the ability to self-repair and a permanent solution for cartilage repair remains elusive. Hydrogel implantation is a promising technique for cartilage repair; however for the technique to be successful hydrogels must interface with the surrounding tissue. The objective of this study was to investigate the tunability of mechanical properties in a hydrogel system using a phenol-substituted polymer, tyramine-substituted hyaluronate (TA-HA), and to determine if the hydrogels could form an interface with cartilage. We hypothesized that tyramine moieties on hyaluronate could crosslink to aromatic amino acids in the cartilage extracellular matrix. Ultraviolet (UV) light and a riboflavin photosensitizer were used to create a hydrogel by tyramine self-crosslinking. The gel mechanical properties were tuned by varying riboflavin concentration, TA-HA concentration, and UV exposure time. Hydrogels formed with a minimum of 2.5 min of UV exposure. The compressive modulus varied from 5 to 16 kPa. Fluorescence spectroscopy analysis found differences in dityramine content. Cyanine-3 labelled tyramide reactivity at the surface of cartilage was dependent on the presence of riboflavin and UV exposure time. Hydrogels fabricated within articular cartilage defects had increasing peak interfacial shear stress at the cartilage-hydrogel interface with increasing UV exposure time, reaching a maximum shear stress 3.5× greater than a press-fit control. Our results found that phenol-substituted polymer/riboflavin systems can be used to fabricate hydrogels with tunable mechanical properties and can interface with the surface tissue, such as articular cartilage.
Knowledge and practice mobilities in the process of policy-making: The case of UK national well-being statistics
Creators: name: Jenkins, Matt
Publisher: name: figshare
Year: 2017
Subjects: subject: Geography
subject: 160403 Social and Cultural Geography
subject: FOS: Social and economic geography

description: This is the submitted version of an article published here, http://www.sciencedirect.com/science/article/pii/S0962629816302098, in Political Geography, in early 2017.
Obligate planktotrophy in the Götte’s larva of Stylochus ellipticus (Platyhelminthes)
Creators: name: J. D. Allen
name: A. M. L. Klompen
name: E. J. Alpert
name: A. J. Reft
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Polyclad flatworms are a diverse and emerging model system for developmental biologists, yet development remains poorly understood for many species. One limitation of polyclads as a model system has been the lack of reliable methods for culturing planktotrophic polyclad larvae to metamorphosis. There are conflicting statements in the literature about which types of polyclad larvae require food to complete development. We developed simple methods for rearing planktotrophic flatworms to metamorphosis and tested the effects of food type and concentration on their development. The flatworm Stylochus ellipticus develops from small (~65 μm) eggs into an obligately planktotrophic Götte’s larva. In this species, development to metamorphosis requires high concentrations (50,000 cells/ml) of the unicellular alga Rhodomonas lens as a food source. High concentrations of two other algal species (Dunaliella tertiolecta and Isochrysis galbana) were successfully ingested by larvae but failed to result in development to metamorphosis. We provide estimates of larval development times and initial descriptions of late larval and early juvenile forms in S. ellipticus. These data provide an important contrast between larval development in obligate planktotrophs and development in non-feeding species. Other indirect developing flatworm species may also be reared using these methods, allowing broader examination of polyclad developmental patterns than previously possible.
Extrusion-based 3D printing of poly(propylene fumarate) scaffolds with hydroxyapatite gradients
Creators: name: Trachtenberg, Jordan E.
name: Placone, Jesse K.
name: Smith, Brandon T.
name: Fisher, John P.
name: Mikos, Antonios G.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified

description: The primary focus of this work is to present the current challenges of printing scaffolds with concentration gradients of nanoparticles with an aim to improve the processing of these scaffolds. Furthermore, we address how print fidelity is related to material composition and emphasize the importance of considering this relationship when developing complex scaffolds for bone implants. The ability to create complex tissues is becoming increasingly relevant in the tissue engineering community. For bone tissue engineering applications, this work demonstrates the ability to use extrusion-based printing techniques to control the spatial deposition of hydroxyapatite (HA) nanoparticles in a 3D composite scaffold. In doing so, we combined the benefits of synthetic, degradable polymers, such as poly(propylene fumarate) (PPF), with osteoconductive HA nanoparticles that provide robust compressive mechanical properties. Furthermore, the final 3D printed scaffolds consisted of well-defined layers with interconnected pores, two critical features for a successful bone implant. To demonstrate a controlled gradient of HA, thermogravimetric analysis was carried out to quantify HA on a per-layer basis. Moreover, we non-destructively evaluated the tendency of HA particles to aggregate within PPF using micro-computed tomography (μCT). This work provides insight for proper fabrication and characterization of composite scaffolds containing particle gradients and has broad applicability for future efforts in fabricating complex scaffolds for tissue engineering applications.
Magnetic solid-phase extraction based on Fe3O4/graphene oxide nanoparticles for the determination of malachite green and crystal violet in environmental water samples by HPLC
Creators: name: Zhang, Leilei
name: Zhang, Yiying
name: Tang, Yurong
name: Li, Xiaorong
name: Zhang, Xinfeng
name: Li, Chaobi
name: Xu, Shuxia
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: This work describes a magnetic Fe3O4/graphene oxide (GO)-based solid-phase extraction (MSPE) technique for high performance liquid chromatography (HPLC) detection of malachite green (MG) and crystal violet (CV) in environmental water samples. Fe3O4/ GO magnetic nanoparticles were synthesised by a chemical co-precipitation method and characterised by scanning electron micrograph, transmission electron microscope, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy and surface area analyser. The prepared Fe3O4/GO magnetic nanoparticles were used as the adsorbents of MSPE for MG and CV. By coupling with HPLC, a sensitive and cost-effective method for simultaneous determination of MG and CV was developed. The important parameters including the amount of Fe3O4/GO, pH of the sample solution, extraction time, salt effect, the type and volume of desorption solvent were investigated in detail. Under optimised conditions, the calibration curves were linear in the concentration range of 0.5–200 μg L−1, and the limits of detection were 0.091 and 0.12 μg L−1 for MG and CV, respectively. Finally, the established MSPE-HPLC method was successfully applied to determine MG and CV in environmental water samples with the recoveries ranging from 91.5% to116.7%.
title: Paratexte (2)_Le Cabinet d'un amateur d'aujourd'hui (deuxième période 1918-1938)
Creators: name: AmateurS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2021

description: Paratexte
description: ID_PARA_01069
Additional file 10: of A pooled analysis of mesenchymal stem cell-based therapy for liver disease
Creators: name: Zhao, Lu
name: Chen, Shanquan
name: Shi, Xiaowei
name: Cao, Hongcui
name: Li, Lanjuan
Publisher: name: figshare
Year: 2018
Subjects: Space Science
Medicine
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Developmental Biology

description: Results of symmetrical contour-enhanced funnel plots combined with trim and fill analysis of TBiL. (PDF 167 kb)
Additional file 1: of A pooled analysis of mesenchymal stem cell-based therapy for liver disease
Creators: name: Zhao, Lu
name: Chen, Shanquan
name: Shi, Xiaowei
name: Cao, Hongcui
name: Li, Lanjuan
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Computational Biology

description: Search strategy. (PDF 52 kb)
Additional file 1 of Childhood PFAS exposure and immunotoxicity: a systematic review and meta-analysis of human studies
Creators: name: Antoniou, Evangelia E.
name: Dekant, Wolfgang
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1: Tables S1–S19 and Figures S1–S7.
Additional file 1: of Gas5 is an essential lncRNA regulator for self-renewal and pluripotency of mouse embryonic stem cells and induced pluripotent stem cells
Creators: name: Tu, Jiajie
name: Tian, Geng
name: Cheung, Hoi-Hung
name: Wei, Wei
name: Lee, Tin-lap
Publisher: name: figshare
Year: 2018
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Computational Biology

description: Figure S1. The promoter region of Gas5 is more conserved than that of the gene body across species. (PDF 1365 kb)
Cadre canadien des services de données nationaux Document de travail
Creators: name: Baker, David
name: Barsky, Eugene
name: Burpee, Jane
name: Leggott, Mark
name: Moon, Jeff
name: Sinatra, Michael
name: Spencer, Byron
name: Gerlitz, Laura
Publisher: name: Zenodo
Year: 2019
Subjects: gestion des données de recherche
infrastructure numérique au milieu de la recherche
services de données nationaux
canada

description: Ce document se veut un document d’information destiné au 2e Sommet sur le CSDN et servira de document de travail aux spécialistes en gestion des données scientifiques du Canada.
Additional file 2: of A pooled analysis of mesenchymal stem cell-based therapy for liver disease
Creators: name: Zhao, Lu
name: Chen, Shanquan
name: Shi, Xiaowei
name: Cao, Hongcui
name: Li, Lanjuan
Publisher: name: figshare
Year: 2018
Subjects: Space Science
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Developmental Biology

description: Results of sensitivity analyses: MELD. (PDF 47 kb)
Additional file 2: of Gas5 is an essential lncRNA regulator for self-renewal and pluripotency of mouse embryonic stem cells and induced pluripotent stem cells
Creators: name: Tu, Jiajie
name: Tian, Geng
name: Cheung, Hoi-Hung
name: Wei, Wei
name: Lee, Tin-lap
Publisher: name: figshare
Year: 2018
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: Figure S2. qPCR results show the knockdown efficiency of lentivirus-mediated Gas5 knockdown in mESCs. *P < 0.05, **P < 0.01, ***P < 0.001, t test, n = 3. Error bars represent SEM of the indicated experiment replicates. (PDF 1365 kb)
Fragment based discovery of DsbA inhibitors
Creators: name: Doak, Bradley Croy
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: DsbA’s are dithiol-disulfide oxidoreductases found in many Gram-negative bacteria. They catalyse the formation of disulfide bonds in many bacterial proteins. Bacteria lacking DsbA display phenotypes associated with the incorrect folding of DsbA substrates, often rendering the bacteria avirulent. DsbA is not present in eukaryotes and several crystal structures are available, thus it presents itself as an attractive antibacterial target and is the protein of interest for this project. To date there are no reported small molecule inhibitors. Previous NMR based screening conducted within the group has identified fragments that bind to Escherichia coli (Ec) DsbA, some of which gave crystal structures. This provided a platform for SBDD and FBDD of a phenylthiophene fragment hit. In the current work, design, synthesis and screening of multiple series of phenylthiophene fragment analogues was conducted. Initial optimisation of the core followed by expansion led to two additional series of compounds that also gave X-ray crystal structures. Their binding mode was found to change significantly from the parent compound highlighting the difficulty in developing EcDsbA inhibitors. Further exploration of the SAR was conducted however with increasingly poor physicochemical properties an accurate affinity measurement is required to assess if ongoing development would lead to suitable compounds. Towards this, a high concentration functional assay for inhibitor screening was developed through synthesis and optimisation of modified peptide substrates employing a fluorescence resonance energy transfer (FRET) lanthanide/coumarin readout. Investigation of the biochemistry of the assay shows weaker than expected inhibition on comparison to NMR data and is currently under further investigation. An alternate strategy for fragment development employing a reactive functional group to produce selective covalent inhibitors was investigated. Synthesis of a clickable fluoromethylketone (FMK) as a thiol selective reactive functional group allowed for the synthesis of a fragment-FMK conjugate which showed selectivity for EcDsbA as well as increased reaction rate due to the incorporation of a low affinity fragment binder. The covalent adduct formed was demonstrated to spontaneously resolve to give oxidised EcDsbA and the corresponding methyl ketone, which is the first report of reduction of a C-F bond by DsbA. Subsequently, the catalytic reduction of the well known thiol-reactive covalent modifier, maleimide was also demonstrated. Screening of additional reactive functional groups support that EcDsbA has a unique thiolate reactivity and this should be taken into account in design of future DsbA covalent inhibitors.
Additional file 3: of A pooled analysis of mesenchymal stem cell-based therapy for liver disease
Creators: name: Zhao, Lu
name: Chen, Shanquan
name: Shi, Xiaowei
name: Cao, Hongcui
name: Li, Lanjuan
Publisher: name: figshare
Year: 2018
Subjects: Space Science
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified
Developmental Biology

description: Results of sensitivity analyses: ALB levels. (PDF 52 kb)
Meatpackers' Costs for Slaughtering Hogs and Distributing Fresh Pork
Creators: name: Agnew, Donald B.
name: Agnew, Donald B.
Publisher: name: Unknown
Year: 1964
Subjects: subject: Labor and Human Capital
subject: Livestock Production/Industries
subject: Marketing
subject: FOS: Economics and business
subject: Production Economics

description: How much of the price the consumer pays for pork is typically paid for meatpackers' services? How are costs of these services allocated among labor, packaging materials, buying and selling, and operating overhead? And how stable are the packers' margins on pork operations when volume of slaughter and prices of live hogs change seasonally? A recent survey of meatpacker costs in commercial-scale fresh pork operations provides some information. Reporting packers were located in the eastern and western Corn Belt and adjoining Southern and Mid-Atlantic States. (Records from packers not slaughtering, or those slaughtering mostly extra heavy hogs and sows, were excluded for the analysis).
description: Reprinted from The Marketing and Transportation Situation February 1964
Additional file 3: of Gas5 is an essential lncRNA regulator for self-renewal and pluripotency of mouse embryonic stem cells and induced pluripotent stem cells
Creators: name: Tu, Jiajie
name: Tian, Geng
name: Cheung, Hoi-Hung
name: Wei, Wei
name: Lee, Tin-lap
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology
subject: Computational Biology

description: Figure S3. Binding site prediction results of Sox2, Oct4, and Nanog in the promoter region of Gas5. (PDF 12625 kb)
Resources and Recreation in the Northern Great Lakes Region; A Department of Agriculture Task Force Report
Creators: name: U. S. Department Of Agriculture
name: U. S. Department Of Agriculture
Publisher: name: Unknown
Year: 1963
Subjects: Community/Rural/Urban Development
Crop Production/Industries
Labor and Human Capital
Land Economics/Use
Livestock Production/Industries
Resource /Energy Economics and Policy

description: Excerpts from the Preface: This report is about opportunities for rural area development in the Northern Great Lakes Region. It originated in Secretary Freeman’s request for an analysis of the potentials for economic development in this extensive forested and lake-studded region. The need for it is accentuated by the tragic disruption of human welfare and community stability through the continuing closedown of deep iron ore mines in part of the region. The objective of this study was to analyze and portray the opportunities for development and multiple use of land and water resources in ways that would be helpful to State and local Rural Areas Development Boards and Committees and other groups in developing plans for improved incomes, employment, community betterment, and more effective resource use. Special attention was to be given to land- and water-based recreation uses that can add to the financial income and employment of people who live in this region.
description: Task Force Members: E. M. Bacon, Forest Service, Task Force Leader; M. H. Cohee, Soil Conservation Service; H. A. Johnson, Economic Research Service; H. C. Davis, Forest Service
Prediction of vitamin D deficiency in older adults: the role of machine learning models
Creators: name: Sluyter, John
name: Raita, Yoshihiko
name: Hasegawa, Kohei
name: Reid, Ian
name: Scragg, Robert
name: Camargo, Carlos
Publisher: name: The University of Auckland
Year: 2022
Subjects: subject: 110306 Endocrinology
subject: FOS: Clinical medicine

description: Supplementary file for manuscript entitled, "Prediction of vitamin D deficiency in older adults: the role of machine learning models"
Citizens minus: rights, recognition and the Nubians of Kenya
Creators: name: Balaton-Chrimes, Samantha
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: This thesis examines the unequal nature of the citizenship of Kenya’s Nubians. The Nubians of Kenya trace their origins to the Egyptian slave armies of the nineteenth century. Brought by the British to Kenya as soldiers they were categorised as detribalized natives during the colonial era, neither settler nor fully native. This anomalous status has carried over into the postcolonial political community, and the Nubians can today be considered ethnic strangers. Far from being liminal in an inconsequential sense, the various ways in which the Nubians have occupied anomalous social, political and legal categories since they arrived in Kenya have been symptomatic of the hierarchical and exclusionary tendencies of the colonial and post-colonial citizenship regimes. This thesis argues that the Nubians are not full citizens, but citizens minus. They experience an unequal and insufficient quality of citizenship. The deficit in the Nubians’ citizenship can be measured by the extent to which they lack participatory parity. Although (most) Nubians now have formal membership in the form of citizenship status (a national identity card), they are lacking in social and political standing, that is, lacking in effective membership. Treated as inferior and limited to the margins of the political community, it is more difficult for Nubians to exercise their rights, and both their formal membership and those rights are insecure. In understanding these deficits, this thesis explores three mechanisms which sustain the Nubians’ marginalisation as ethnic strangers and citizens minus: discrimination in relation to access to national identity cards, the withholding of collective recognition as a tribe of Kenya, and the withholding of recognition of Nubian land in the form of communal land title. In evaluating these mechanisms the thesis draws on political theories of recognition and connects the Nubians’ exclusion from full citizenship to the widespread privileging of indigeneity and autochthony as conditions of full citizenship in Kenya. In making this argument, the thesis addresses a number of critical questions about the nature of citizenship in Kenya, arguing that national citizenship in Kenya is largely subordinate to and defined by ethnicity. Throughout the thesis, and particularly in the final chapters, the thesis seeks to understand the Nubians’ response to their marginalisation, and the reasons why, and ways in which, they affirm a role for ethnicity in public affairs. In the final chapter the thesis engages in a critique of this role, and an exploration of a moderately transformative approach to ethnicity in the form of moral-inter ethnicity. Such an approach may allow Kenyans to affirm the importance of ethnicity in daily life and in the polity, without affirming ethnic parochialism and inter-ethnic competition, and thereby undermining equal citizenship.
Health investment, health outcomes and economic growth in China: an applied macroeconomic analysis
Creators: name: Chen, Gang
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Health is regarded as an important dimension of human development and its crucial role as human capital has been long recognised; however, the strategic role of health investment remains undervalued in less developed regions. China is a very good example of this. Along with the economic transition in the past three decades, China’s health care system has also undergone several major changes. A key policy change was a shift of the main responsibility of health care finance to the individual in the early 1990s and a reversal of this in the early 2000s after the SARS epidemic. Possibly as a result of this, the population’s health status is reported to be performing below its potential. This thesis conducts a thorough empirical investigation of the various and varied relationships between health investment, health outcomes and economic growth in China, using publicly available macro data; thus it makes a significant contribution to the academic literature, as well as provides evidence for policy-makers in both China and other countries in transition. More specifically, this thesis empirically studies (1) the long-run relationship between health investment and economic output; and (2) the short-run nexus between health expenditure behaviours, health status and economic fluctuations, through both national time series and provincial-level panel data from mainland China. Overall, the results suggest that health investment has a significant and positive role in explaining the level of economic output in the long-run; and an estimated stronger effect in inland China may further highlight diminishing returns in health investment. The short-run results also suggest a significantly pro-cyclical movement of government health expenditure with economic growth. Furthermore, child health outcomes and infectious disease incidence are also significantly associated with economic fluctuations.
Elucidating the role of TLR2 in STAT3-mediated gastric tumourigenesis
Creators: name: Tye, Yuet Mei
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Gastric cancer (GC) is the second most lethal form of cancer world-wide, which represents a subset of inflammation-associated carcinogenesis. While it is accepted that deregulated interactions between gastric microbes (i.e. Helicobacter pylori) and the host innate immune system are likely to be involved in the pathogenesis of gastric inflammation (gastritis) and the development GC, the identity of oncogenic inflammatory regulators in the host gastric mucosa remains obscure. On this note, uncontrolled activation of cytokine signalling pathways, especially the pro-inflammatory and oncogenic transcription factor signal transducer and activator of transcription (STAT) 3, is implicated in various inflammation-associated cancers, including up to 50% of human GC cases. However, the downstream molecular consequences of aberrant STAT3 activation in promoting gastritis and subsequently gastric tumorigenesis are ill-defined. This thesis addresses the role of toll-like receptors (TLRs) which are key components of the innate immune system primarily known to trigger an inflammatory response upon pathogen detection during gastric tumourigenesis. Our mouse model for GC, was generated by a specific “knock-in” phenylalanine substitution at tyrosine 757 in the interleukin (IL)-6 cytokine family co-receptor gp130 (gp130F/F), which abolishes the negative feedback mechanism, thus leading to gp130-STAT3 hyper-activation. These mice spontaneously developed gastric hyperplasia and adenomatous lesions that resembled histopathological features similar to human intestinal-type GC. Notably, aberrant STAT3 activation in the gastric compartment of these mice directly caused a significant increase in the expression of TLR2, a receptor that is responsible for recognising a broad range of microbial products. In addition, genetic deletion of TLR2 in gp130F/F mice severely reduced the gastric tumour mass by approximately 50%. However, unexpectedly, the level of gastritis was comparable to gp130F/F mice. Interestingly, immunohistochemical analyses revealed that gp130F/F:Tlr2-/- mice had increased TUNEL-positive apoptotic cells and reduced PCNA-positive cells in the gastric mucosal epithelium, therefore implicating a role for TLR2 in gastric epithelial cell proliferation and survival. Consistent with our mouse data, we identified that activating TLR2, using synthetic lipopeptides, in human gastric epithelial cell lines promoted gastric epithelial cell proliferation. Collectively, our data depicts an unexpected role for TLR2 in gastric tumourigenesis, whereby increased STAT3 activation resulted in over-expression of TLR2 to promote gastric tumour cell growth.
Additional file 4: of A pooled analysis of mesenchymal stem cell-based therapy for liver disease
Creators: name: Zhao, Lu
name: Chen, Shanquan
name: Shi, Xiaowei
name: Cao, Hongcui
name: Li, Lanjuan
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Visualized results of publication bias of ALB. (PDF 120 kb)
Additional file 5: of A pooled analysis of mesenchymal stem cell-based therapy for liver disease
Creators: name: Zhao, Lu
name: Chen, Shanquan
name: Shi, Xiaowei
name: Cao, Hongcui
name: Li, Lanjuan
Publisher: name: figshare
Year: 2018
Subjects: Space Science
Medicine
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Mathematical Sciences not elsewhere classified

description: Results of symmetrical contour-enhanced funnel plots combined with trim and fill analysis of ALB. (PDF 165 kb)
Additional file 4: of Gas5 is an essential lncRNA regulator for self-renewal and pluripotency of mouse embryonic stem cells and induced pluripotent stem cells
Creators: name: Tu, Jiajie
name: Tian, Geng
name: Cheung, Hoi-Hung
name: Wei, Wei
name: Lee, Tin-lap
Publisher: name: figshare
Year: 2018
Subjects: Space Science
Cell Biology
Biological Sciences not elsewhere classified
Developmental Biology
Science Policy
Hematology

description: Figure S4. Gas5 KD did not affect mESC proliferation under regular culture conditions (with LIF). (PDF 730 kb)
Titanium-oxide nanomaterials: synthesis, characterization, and selective photocatalysis
Creators: name: Ainikalkannath Lazar, Manoj
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: The side effects of some recent scientific advances challenge the well-being of our planet. Water contamination, one of these side effects, from industrial effluents is a major source of fresh water pollution. Semiconductor photocatalysis, which operates under ultraviolet or visible light irradiation, is a well proven approach to water de-contamination. Among the various available semiconductor photocatalysts, nanocrystalline titanium-oxides are unique in their activity, stability and biocompatibility. Consequently titanium-oxide mediated photocatalytic mineralization of organic pollutants in aqueous solution has become a well established research area. Titanium-oxides are mostly exploited as non-selective photocatalysts in degrading water contaminants, mainly organic compounds. However, selective degradation has the advantage of being able to allow the recovery of valuable desired compounds from waste water while degrading the rest. This thesis is about the synthesis, characterization and selective adsorption and degradation properties of titanium dioxide and potassium titanate nanostructures. A low-temperature sol-gel method followed by a pH controlled precipitation technique was adopted for the synthesis of titanium dioxide photocatalysts with tailored surface charge. Potassium titanate was derived by the alkali (KOH) treatment of titanium dioxide nanoparticles under near-ambient experimental conditions. These nanomaterials were tested for their selective adsorption and photocatalytic properties with a cationic and an anionic dye. The origin of the selective adsorption and photocatalytic ability of the synthesized titanium-oxide samples was found to be due to the synergistic effects of surface charge and crystallinity.
Additional file 6: of A pooled analysis of mesenchymal stem cell-based therapy for liver disease
Creators: name: Zhao, Lu
name: Chen, Shanquan
name: Shi, Xiaowei
name: Cao, Hongcui
name: Li, Lanjuan
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Genetics
subject: FOS: Biological sciences
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Developmental Biology

description: Results of sensitivity analyses: ALT levels. (PDF 41 kb)
MIR-7 targets pax6 and modulates bladder cancer cell migration
Creators: name: Quantin, Renaud Pierre
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: Transitional cell carcinoma (TCC) of the bladder is one of the 10 most common cancers in Australia. Bladder cancer incidence increases with the age and is 3-4 times as common in males compared to females. Invasive bladder cancer is the major cause of death among people diagnosed with urothelial cancer. The work presented in this thesis aims to better understand the development and progression of bladder cancer in humans. This thesis focuses on the role played by miR-7 and its downstream target Pax6, using a novel cell model of human bladder transitional cell carcinoma. This model consists of TSU-Pr1 and TSU-Pr1-B2, two highly related cell lines that were originally derived from the T24 bladder cancer cell line. TSU-Pr1-B2 is a subline of TSU-Pr1 that was generated through in vivo selection for metastatic cells following systemic inoculation. In the present study, a low expression level of miR-7 was observed in the epithelial-like TSU-Pr1-B2 cells compared to the more mesenchymal-like TSU-Pr1 cells. Overexpression of miR-7 in TSU-Pr1-B2 cells inhibited cell migration and reduced cell speed in vitro. Bioinformatic analyses predicted four putative miR-7 binding sites in the Pax6 3’ UTR. This interaction was confirmed using a luciferase reporter assay. Further experiments showed that knock-down of Pax6 in TSU-Pr1-B2 cells also impaired cell migration and decreased cell speed in vitro. These results suggested that miR-7 decreased cell migration in vitro by down-regulating Pax6. Integrin-Linked Kinase (ILK) was identified as a potential novel downstream target of Pax6. ILK promoter activity decreased when Pax6 was overexpressed. Therefore, I postulated that Pax6 could regulate ILK, providing a novel pathway for miR-7 mediated regulation of bladder cancer progression. This study provides new insights in the molecular mechanisms mediating migration of urothelial cancer cells and implicates a miR-7/Pax6/ILK signalling pathway in this process.
MOESM1 of Effect of CBM1 and linker region on enzymatic properties of a novel thermostable dimeric GH10 xylanase (Xyn10A) from filamentous fungus Aspergillus fumigatus Z5
Creators: name: Miao, Youzhi
name: Kong, Yanqiong
name: Li, Pan
name: Li, Guangqi
name: Liu, Dongyang
name: Shen, Qirong
name: Zhang, Ruifu
Publisher: name: figshare
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Biotechnology
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Table S1. Primers used for enzyme expressions.
Additional file 7: of A pooled analysis of mesenchymal stem cell-based therapy for liver disease
Creators: name: Zhao, Lu
name: Chen, Shanquan
name: Shi, Xiaowei
name: Cao, Hongcui
name: Li, Lanjuan
Publisher: name: figshare
Year: 2018
Subjects: subject: Space Science
subject: Medicine
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Visualized results of publication bias of ALT. (PDF 106 kb)
On the use of visual conceptual information for the indexing and retrieval of image regions
Creators: name: Jarrar, Radi
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: To address the semantic gap, state-of-the-art automatic image annotation frameworks concatenate the low-level image features (such as color, texture, etc.) in high- dimensional spaces to learn a set of high-level semantic categories. This research work investigates a multimedia indexing framework establishing a correspondence between visual conceptual information representing image regions and a set of high-level semantic concepts. The computational models for extracting the visual color, texture, and shape concepts utilized in this thesis aim to capture aspects related to human perception and understanding of the color, texture, and shape features of image regions. Through the development of models that map the low-level features into a set of high-level symbolic descriptors, image regions are described in transparent and readable form. These symbolic descriptors, named in this thesis as the visual concepts, are then used to learn a set of high-level semantic categories to classify un-annotated image regions. A main contribution here is presenting a framework for characterizing visual shape concepts to describe the shapes of image regions. The efficiency of using the visual conceptual information is demonstrated by conducting a comparison with a baseline framework operating on a set of low-level image features to learn the same set of semantic categories. Using the visual concepts to describe image regions is shown to achieve promising results and outperform the baseline model. The experimental results show that using the visual conceptual information to describe image contents achieves the goal of this thesis of narrowing the semantic gap between the low-level image features and high-level semantic categories.
Oral communication strategies: task-based learning and Indonesian EFL learners
Creators: name: Rohani, Siti
Publisher: name: Monash University
Year: 2017
Subjects: Uncategorized

description: This study investigated the use of oral communication strategies during implementation of Task-Based Learning (TBL) in a tertiary English language class in Indonesia. Three research questions were addressed: students’ responses toward the implementation of TBL, oral communication strategies used, and shifts in use of oral communication strategies after the implementation of TBL for one semester. The study employed both quantitative and qualitative measurement of the data. Findings at the beginning of semester were compared to those at the end of semester. Reliability of the data was maintained through multi methods employed, including Oral Communication Strategy Inventory (OCSI) administered at the beginning and end of semester, learning journals of 26 students administered throughout the semester, focus group discussion with twelve students conducted at the end of semester, in-depth interviews with ten students to confirm the findings from the OCSI, stimulated recall interviews with fourteen students conducted at the end of semester, and video-taped classroom activities held throughout the semester. Findings indicate positive responses to TBL. Toward the end of semester, students believed their oral communication skills had improved. There was evidence of increased self-esteem, risk-taking behaviour, and motivation to learn English. Quantitative findings suggest that, toward the end of semester, students increasingly used positive strategies for coping with both speaking and listening problems. Use of negative strategies was significantly reduced. Qualitative findings confirm quantitative findings, suggesting students’ improved strategic competence in oral communication skills. Positive strategies were increasingly used while negative strategy use was reduced. There was also some evidence that the higher the students’ levels of oral proficiency, the greater the likelihood of their increasing use of positive strategies and reducing the use of negatives strategies. Reasons for this shift reported by students included higher self-esteem, higher motivation to be more actively engaged in communication and to learn English as well as improved linguistic competence, especially in the area of vocabulary.