cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
OSTrails Interoperability Framework – FAIR-IF: A Unified Framework for Consistently FAIRifying Research Outputs.
Creators: name: Wilkinson, Mark
Publisher: name: Zenodo
Year: 2025
Subjects: FAIR Interoperability Framework (FAIR-IF)
FAIR evaluation tools
Assessment components

description: This is the first webinar of the OSTrails Interoperability Webinar Series, focusing on the FAIR-IF initiative, held on 28 April 2025. In this session, Mark Wilkinson (UPM, Madrid) presents how FAIR-IF aims to harmonize the behavior of FAIR assessment tools, ensuring that the choice of a tool becomes secondary to the choice of benchmarks. The vision is that FAIR assessment tools will eventually be seamlessly integrated into other environments, such as DMP authoring platforms, making their use nearly invisible to the end user.

The webinar covers the overall conceptual framework for FAIR testing, detailing how a specific test relates to a Metric, how a Metric relates to a Benchmark, and how metadata about these entities can be retrieved. It also explores the current capabilities for invoking FAIR assessments at the Metric level, and outlines the plans for developing the final stage: enabling communities to author and execute their own benchmarks on digital objects. Finally, the session presents the vision for embedding actionable advice into assessment outputs, shifting the role of assessments from simple evaluation to supportive guidance.
Hormones as go‐betweens in plant microbiome assembly
Creators: name: Eichmann, Ruth
name: Richards, Luke
name: Schäfer, Patrick
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: endosphere
subject: microbiota
subject: DDC 580 / Botanical sciences
subject: Plants Development
subject: Plants Evolution
subject: Rhizosphere
subject: Symbiosis
subject: Rhizosphäre
subject: Symbiose

description: The interaction of plants with complex microbial communities is the result of co-evolution over millions of years and contributed to plant transition and adaptation to land. The ability of plants to be an essential part of complex and highly dynamic ecosystems is dependent on their interaction with diverse microbial communities. Plant microbiota can support, and even enable, the diverse functions of plants and are crucial in sustaining plant fitness under often rapidly changing environments. The composition and diversity of microbiota differs between plant and soil compartments. It indicates that microbial communities in these compartments are not static but are adjusted by the environment as well as inter-microbial and plant–microbe communication. Hormones take a crucial role in contributing to the assembly of plant microbiomes, and plants and microbes often employ the same hormones with completely different intentions. Here, the function of hormones as go-betweens between plants and microbes to influence the shape of plant microbial communities is discussed. The versatility of plant and microbe-derived hormones essentially contributes to the creation of habitats that are the origin of diversity and, thus, multifunctionality of plants, their microbiota and ultimately ecosystems.
Plugging the 3MC sink in ru-II‐based photocatalysts
Creators: name: Shillito, Georgina E.
name: Rau, Sven
name: Kupfer, Stephan
Publisher: name: Universität Ulm
Year: 2023
Subjects: subject: TDDFT
subject: electron transfer
subject: Marcus theory
subject: molecular photocatalysts
subject: DDC 540 / Chemistry & allied sciences
subject: Charge exchange
subject: Fotokatalyse

description: Abstract Quantum chemical methods have been utilised to explore the kinetics and thermodynamics of a prominent charge recombination pathway in a series of RuII based molecular photocatalysts. Selective tuning of the RuII coordination sphere, replacing the tbbpy ligands of the hydrogen evolving parent photocatalyst with electron rich, biimidazole based ligands, promotes unidirectional charge transfer towards the bridging ligand during initial photoexcitation. These electronic effects are also significant in the triplet manifold, where the predicted rate of the undesired deactivation process from the 3MLCT state on the bridging ligand to a 3MC state on the ruthenium centre, is decreased relative to the parent complex, by 1–2 orders of magnitude, alongside a decrease in electronic coupling. This design methodology could be utilised to promote targeted (light‐driven) electron transfer pathways, as well as to potentially reduce 3MC deactivation pathways in commonly used polypyridyl‐based RuII photocentres, thus enhancing the quantum efficiency of light driven catalysis.
description: Photocatalysis: The photophysical properties of a series of RuII based photocatalysts are investigated by means of quantum chemical methods. Through selective co‐ligand design, greater control can be exerted over the electron transfer pathways, targeted at increasing electron localisation on the bridging ligand and reducing deactivation through 3MC states. image
Path Adventure - 23215385 - Aulia Muslim Hidayatullah
Creators: name: Hidayatullah, Aulia Muslim
Publisher: name: figshare
Year: 2016
Subjects: subject: 80305 Multimedia Programming
subject: FOS: Computer and information sciences

description: Pathfinding Adventure bertujuan untuk membantu pemain dalam memahami konsep matematika kelas 8 mengenai sistem koordinat. Pada game ini pemain dapat berpetualang di area khusus untuk mencari dan menggambar peta dari hasil perjalanan dalam melaksanakan misi di setiap tingkatan permainan.
Pemain diberikan akses kontrol pada game dalam format “2D Platformer” dan “Turn Based”. Menyelesaikan tantangan-tantangan yang diberikan di setiap tingkatan adalah salah satu cara untuk mendapatkan arah koordinat akhir pada misi di setiap tingkatan permainan. Dari data yang didapatkan, diharapkan pemain dapat memahami metode pengaturan koordinat peta dengan menggunakan koordinat sumbu X & Y berdasarkan perjalanan yang telah dilalui.
Ada berbagaimacam aksi dalam suatu misi yang dapat dilakukan yaitu, melakukan pertarungan melawan kecerdasan buatan atau AI (Artificial Intelligence), puzzle game dengan implementasi sistem koordinat, dan memecahkan koordinat jalur yang harus dilalui.
Github:
https://github.com/lskk/Pathfinding_Adventures
Additional file 1 of Single-cell RNA sequencing of the retina in a model of retinitis pigmentosa reveals early responses to degeneration in rods and cones
Creators: name: Karademir, Duygu
name: Todorova, Vyara
name: Ebner, Lynn J. A.
name: Samardzija, Marijana
name: Grimm, Christian
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 1: Figure S1. Validation of the degenerative state of rd10 retinas at P21. Fundus images (left panels) and OCT scans (right panels) of (A) rd10 mouse 1, (B) rd10 mouse 2, and (C) a wild-type mouse at P21. Mice were littermates of rd10 and wild-type mice used for scRNAseq. Red lines in fundus images mark the location of OCT scans. The vertical black bars on OCT images mark the outer retina (outer plexiform layer to photoreceptor segments). Scale bars: 100 μm.
Path Adventure
Creators: name: Hidayatullah, Aulia Muslim
Publisher: name: figshare
Year: 2016
Subjects: subject: 80305 Multimedia Programming
subject: FOS: Computer and information sciences

description: Pathfinding Adventure bertujuan untuk membantu pemain dalam memahami konsep matematika kelas 8 mengenai sistem koordinat. Pada game ini pemain dapat berpetualang di area khusus untuk mencari dan menggambar peta dari hasil perjalanan dalam melaksanakan misi di setiap tingkatan permainan.
Pemain diberikan akses kontrol pada game dalam format “2D Platformer” dan “Turn Based”. Menyelesaikan tantangan-tantangan yang diberikan di setiap tingkatan adalah salah satu cara untuk mendapatkan arah koordinat akhir pada misi di setiap tingkatan permainan. Dari data yang didapatkan, diharapkan pemain dapat memahami metode pengaturan koordinat peta dengan menggunakan koordinat sumbu X & Y berdasarkan perjalanan yang telah dilalui.
Ada berbagaimacam aksi dalam suatu misi yang dapat dilakukan yaitu, melakukan pertarungan melawan kecerdasan buatan atau AI (Artificial Intelligence), puzzle game dengan implementasi sistem koordinat, dan memecahkan koordinat jalur yang harus dilalui.
Github:
https://github.com/lskk/Pathfinding_Adventures
New draft item
Creators: name: Hidayatullah, Aulia Muslim
Publisher: name: figshare
Year: 2016
Subjects: subject: 80305 Multimedia Programming
subject: FOS: Computer and information sciences

description: Pathfinding Adventure bertujuan untuk membantu pemain dalam memahami konsep matematika kelas 8 mengenai sistem koordinat. Pada game ini pemain dapat berpetualang di area khusus untuk mencari dan menggambar peta dari hasil perjalanan dalam melaksanakan misi di setiap tingkatan permainan.
Pemain diberikan akses kontrol pada game dalam format “2D Platformer” dan “Turn Based”. Menyelesaikan tantangan-tantangan yang diberikan di setiap tingkatan adalah salah satu cara untuk mendapatkan arah koordinat akhir pada misi di setiap tingkatan permainan. Dari data yang didapatkan, diharapkan pemain dapat memahami metode pengaturan koordinat peta dengan menggunakan koordinat sumbu X & Y berdasarkan perjalanan yang telah dilalui.
Ada berbagaimacam aksi dalam suatu misi yang dapat dilakukan yaitu, melakukan pertarungan melawan kecerdasan buatan atau AI (Artificial Intelligence), puzzle game dengan implementasi sistem koordinat, dan memecahkan koordinat jalur yang harus dilalui.
Cosmology and Cancer in the Post-Star-Trek Centuries
Creators: name: Bartlett, Karen
Publisher: name: figshare
Year: 2016
Subjects: subject: Cosmology
subject: Astrophysics
subject: 20105 General Relativity and Gravitational Waves
subject: FOS: Physical sciences
subject: Space Science
subject: Stellar Astronomy
subject: 60303 Biological Adaptation
subject: FOS: Biological sciences
subject: Biological Engineering
subject: Biophysics
subject: Biotechnology
subject: Cancer
subject: Evolutionary Biology
subject: Medicine
subject: Neuroscience
subject: Applied Computer Science
subject: Computation Theory and Mathematics
subject: FOS: Computer and information sciences
subject: 80611 Information Systems Theory
subject: Theoretical Computer Science
subject: Geometry
subject: 10504 Mathematical Aspects of General Relativity
subject: FOS: Mathematics
subject: 10599 Mathematical Physics not elsewhere classified
subject: 10112 Topology
subject: Uncategorized
subject: Applied Physics
subject: Condensed Matter Physics
subject: Entropy
subject: General Relativity
subject: 29903 Medical Physics
subject: 20203 Particle Physics
subject: Quantum Mechanics
subject: Thermodynamics
subject: Atomic Physics

description: AThis is definitely not a work of science fiction. It's a serious 9,000 words detailing what today's philosophy and science (in areas like physics, computer science, cosmology, biology and mathematics) are likely to evolve into. I've always been totally fascinated by the future – the more distant, the better! So the adventures of the Star Trek movies and TV shows, based in the 23rd and 24th centuries, are a good starting point. They're not documentaries by any stretch but are a tremendous boost to the sense of wonder about the universe. Superman and Doctor Who are also great at making a person wonder about new possibilities in other centuries and other parts of the cosmos. Putting together the marvels of science fiction and the marvels of science results in the following picture of what lies in store for humanity and the cosmos. In the end, this new science and philosophy is my opinion and only time can determine its accuracy.
Path Adventure
Creators: name: Hidayatullah, Aulia Muslim
Publisher: name: figshare
Year: 2016
Subjects: subject: 80305 Multimedia Programming
subject: FOS: Computer and information sciences

description: Pathfinding Adventure bertujuan untuk membantu pemain dalam memahami konsep matematika kelas 8 mengenai sistem koordinat. Pada game ini pemain dapat berpetualang di area khusus untuk mencari dan menggambar peta dari hasil perjalanan dalam melaksanakan misi di setiap tingkatan permainan.
Pemain diberikan akses kontrol pada game dalam format “2D Platformer” dan “Turn Based”. Menyelesaikan tantangan-tantangan yang diberikan di setiap tingkatan adalah salah satu cara untuk mendapatkan arah koordinat akhir pada misi di setiap tingkatan permainan. Dari data yang didapatkan, diharapkan pemain dapat memahami metode pengaturan koordinat peta dengan menggunakan koordinat sumbu X & Y berdasarkan perjalanan yang telah dilalui.
Ada berbagaimacam aksi dalam suatu misi yang dapat dilakukan yaitu, melakukan pertarungan melawan kecerdasan buatan atau AI (Artificial Intelligence), puzzle game dengan implementasi sistem koordinat, dan memecahkan koordinat jalur yang harus dilalui.
DATA COLLECTION
Creators: name: Luciara Fabiane Sebold
name: Amante, Lucia Nazareth
name: Vicente, Camila
name: SILVEIRA, LORENA BARROS DA
name: Huiana Cristine Lucca
Publisher: name: OSF Registries
Year: 2024

description: Selection process
1. Combine health descriptors with related keywords through crossings with Boolean operators, according to each database, according to the strategy developed by the librarian.
2. Forward the identified materials to Mendley bibliographic reference manager software in order to identify repeated materials and exclude them. Most used managers:
3. Go through the titles and abstracts of each reference and decide whether or not the study described is potentially eligible for inclusion, according to the criteria already established in this protocol. If you are unsure about a specific study, keep it on the selected list for now.
4. Examine each study in more detail, analyzing the text to determine eligibility that was not clear in the first selection.
5. Decide in consensus meetings to exclude or include the article. All reasons for excluding articles must be explained after reading the articles in full.

Data extraction process
1. Detail the data extraction process in accordance with PRISMA-ScR (2018) – Annex B. Use flowchart templates according to the data sources in addition to the electronic databases and records used. If necessary, adapt the figures in the proposed flowchart.
2. Extract data from primary studies according to the research object, in line with the JBI.
3- Compile the data into a synoptic table.
Additional file 2 of Single-cell RNA sequencing of the retina in a model of retinitis pigmentosa reveals early responses to degeneration in rods and cones
Creators: name: Karademir, Duygu
name: Todorova, Vyara
name: Ebner, Lynn J. A.
name: Samardzija, Marijana
name: Grimm, Christian
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Additional file 2: Figure S2. Additional quality control measures on the single-cell transcriptomic dataset. (A) Two-dimensional tSNE plot of the whole dataset before low-quality clusters were filtered. Filtered clusters have the tag “: Omitted” and are labeled with “M” (Müller glia-rods) and “R” (Rods) in the tSNE plot. (B-D) Quality control measures for the omitted rod cluster, compared to the three retained rod clusters C01, C02 and C03. The omitted cluster has lower numbers of total features (B) and transcripts (C) but a higher percentage of mitochondrial transcripts (“mt-genes”) per cell (D). (E) Differential gene expression analysis between omitted and retained rod clusters shows that omitted rods have higher levels of ribosomal transcripts. (F) Differential gene expression analysis between omitted and retained Müller glia cluster shows that omitted Müller glia are positive for rod cell markers (e.g., Sag, Rho) and express lower levels of Müller glia markers (e.g., Dkk3).
Repositories as a Corner Stone of Publication Cost Transparency : XML, OAI-PMH and all that
Creators: name: Stein, Lisa-Marie
name: Wagner, Alexander
name: Bartlewski, Julia
name: Broschinski, Christoph
name: Pieper, Dirk
name: Deinzer, Gernot
name: Schweighofer, Bianca
name: Sippl, Colin
name: Weisheit, Silke
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2024

description: The 19th International Conference on Open Repositories, OpenRepositories24, Göteborg, Sweden, 3 Jun 2024 - 6 Jun 2024
description: With the rise of Gold Open Access publishing in "author pays" models a new kind of metadata gains importance: costs directly associated with publications. Adding so-called transformative agreements as well as scholarly led Open Access to the mix further increases their importance, as cost transparency has to be a guiding principle for sustainability.Repositories provide high quality metadata in various formats via established interfaces. Enhancing these metadata by cost data thus makes them a potential corner stone to achieve the desired transparency.Therefore, the project openCost developed, together with the community, a XML schema to model cost data both for individual articles and, most recently, to handle contracts.We give an in-depth view of the openCost schema, demonstrate real world implementations and provide some glimpses on an associated workflow to collect the data. This will enable developers to gain an understanding of the requirements for adding openCost compatibility to existing repository systems.Tbe openCost partner University of Bielefeld already implemented harvesting of the openCost format via OAI-PMH for their own, openly available aggregator platform OpenAPC. Their openly available metadata store allows a wide variety of analyses and thus showcases the strength of the openCost approach.
Honest, open, proud to support disclosure decisions and to decrease stigma’s impact among people with mental illness : conceptual review and meta-analysis of program efficacy
Creators: name: Rüsch, Nicolas
name: Kösters, Markus
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Stigma
subject: Self-stigma
subject: Stigma stress
subject: Honest, Open, Proud
subject: Coming Out Proud
subject: Peer intervention
subject: DDC 150 / Psychology
subject: Stigma (Social psychology)
subject: Mentally ill persons
subject: Prejudice
subject: Disclosure
subject: Meta-analysis
subject: Psychisch Kranker
subject: Stigmatisierung
subject: Selbstöffnung

description: Purpose Honest, Open, Proud (HOP; formerly “Coming Out Proud”/COP) is a peer-led group program to support people with mental illness in their disclosure decisions and in their coping with stigma. The aims of this study were to provide (i) a conceptual review of HOP, including versions for different target groups and issues related to outcome measurement and implementation; and (ii) a meta-analysis of program efficacy. Methods Conceptual and empirical literature on disclosure and the HOP program was reviewed. Controlled trials of HOP/COP were searched in literature databases. A meta-analysis of HOP efficacy in terms of key outcomes was conducted. Results HOP program adaptations for different target groups (e.g. parents of children with mental illness; veterans or active soldiers with mental illness) exist and await evaluation. Recruitment for trials and program implementation may be challenging. A meta-analysis of five HOP RCTs for adults or adolescents with mental illness or adult survivors of suicide attempts found significant positive effects on stigma stress (smd = − 0.50) as well as smaller, statistically non-significant effects on self-stigma (smd = − 0.17) and depression (smd = − 0.11) at the end of the HOP program. At 3- to 4-week follow-up, there was a modest, not statistically significant effect on stigma stress (smd = − 0.40, 95%-CI -0.83 to 0.04), while effects for self-stigma were small and significant (smd = − 0.24). Long-term effects of the HOP program are unknown. Conclusion There is initial evidence that HOP effectively supports people with mental illness in their disclosure decisions and in their coping with stigma. Implementation issues, future developments and public health implications are discussed.
Investigation of control structures for a four‐product laboratory multiple dividing‐wall column using dynamic simulation
Creators: name: Preißinger, Ulrich
name: Lukač, Goran
name: Dejanović, Igor
name: Grützner, Thomas
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Column control
subject: Dividing‐wall column
subject: Dynamic simulation
subject: Four‐product column
subject: DDC 540 / Chemistry & allied sciences
subject: Distillation
subject: Destillation

description: Multiple dividing‐wall columns offer high investment and energy cost savings in distillation. To ensure these savings during operation, robust control structures must be applied. Three basically simple and practical control structures were investigated for a simplified multiple dividing‐wall column. All three control structures allow a robust control of the laboratory column. The dynamic behavior of a multiple dividing‐wall column pilot plant is evaluated by means of dynamic simulation. Three different control structures are developed or adapted from the literature, which are constrained by the actual design features of the pilot plant column. Since in the present case the design of the column was chosen such that very different mixtures can be separated, it cannot be optimally designed for each of these potential mixtures. Rather, the design focused on the flexibility of the plant. All three investigated control structures were tested on feed flow rate and feed composition disturbance and allowed a robust control of the pilot plant, whereby control structure 2 is slightly better than others in terms of steady‐state deviations and less pronounced fluctuations during the dynamic phase. The transferability of control structure 2 to other variants of multiple dividing‐wall columns is easily possible.
List of objects found by metal detectorists in the Kendal area in recent years.
Creators: name: Marsh, John
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 96, 238-240
description: Ten objects including a late medieval cloisonn� enamelled heart-shaped object, RB trumpet brooch, lead alloy male head, bronze mace head, Henry II short cross pennies, a wool seal and a bronze seal.
Body fat compartment determination by encoder–decoder convolutional neural network: application to amyotrophic lateral sclerosis
Creators: name: Vernikouskaya, Ina
name: Müller, Hans‑Peter
name: Felbel, Dominik Jochen
name: Roselli, Francesco
name: Ludolph, Albert C.
name: Kassubek, Jan Rainer
name: Rasche, Volker
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: Computer science
subject: DDC 610 / Medicine & health
subject: Amyotrophic lateral sclerosis
subject: Subcutaneous fat
subject: Intra-abdominal fat
subject: Biomarkers
subject: Myatrophische Lateralsklerose
subject: Biomarker
subject: Fettgewebe

description: The objective of this study was to automate the discrimination and quantification of human abdominal body fat compartments into subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) from T1-weighted MRI using encoder-decoder convolutional neural networks (CNN) and to apply the algorithm to a diseased patient sample, i.e., patients with amyotrophic lateral sclerosis (ALS). One-hundred-and-fifty-five participants (74 patients with ALS and 81 healthy controls) were split in training (50%), validation (6%), and test (44%) data. SAT and VAT volumes were determined by a novel automated CNN-based algorithm of U-Net like architecture in comparison with an established protocol with semi-automatic assessment as the reference. The dice coefficients between the CNN predicted masks and the reference segmentation were 0.87 ± 0.04 for SAT and 0.64 ± 0.17 for VAT in the control group and 0.87 ± 0.08 for SAT and 0.68 ± 0.15 for VAT in the ALS group. The significantly increased VAT/SAT ratio in the ALS group in comparison to controls confirmed the previous results. In summary, the CNN approach using CNN of U-Net architecture for automated segmentation of abdominal adipose tissue substantially facilitates data processing and offers the opportunity to automatically discriminate abdominal SAT and VAT compartments. Within the research field of neurodegenerative disorders with body composition alterations like ALS, the unbiased analysis of body fat components might pave the way for these parameters as a potential biological marker or a secondary read-out for clinical trials.
Finds from Veterae, The Roman Fort of Brough.
Creators: name: Woolliscroft, David J
name: Lockett, N J J
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 96, 230-233
description: Fieldwalking at Brough-under-Stainmore fort brought forth Roman coins, nails, pottery (coarse and samian and post-Roman) and glass.
Neural substrates of anorexia nervosa patient’s deficits to decode emotional information
Creators: name: Lulé, Dorothée
name: Müller, Sabine
name: Fladung, Anne-Katharina
name: Uttner, Ingo
name: Schulze, Ulrike M. E.
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: DDC 150 / Psychology
subject: DDC 610 / Medicine & health
subject: Emotion recognition
subject: Alexithymia
subject: Anorexia nervosa
subject: Emotions
subject: Anxiety
subject: Depression
subject: Affective symptoms
subject: Anorexia nervosa
subject: Alexithymie
subject: Angst
subject: Depression

description: Purpose The aim of the study was to define specific substrates of pathological behaviour patterns by analysing cortical activity using functional magnetic resonance imaging (fMRI) during an emotional processing task. Methods In a sample of N = 11 adolescent patients with AN (16.36 years, SD ± 1.36) and N = 11 age-matched controls, we performed a functional MRI study to detect BOLD signal changes in a 3 T MRI scanner while presenting emotional facial stimuli. Results Young people with AN presented with a generally reduced cortical activation pattern in key areas of emotion recognition for happy and fearful faces. Areas essential for control of social behaviour were associated with symptoms of depression. Conclusion Obviously, there are already indications of cortical patterns in young affected persons, which indicate a changed emotional reaction to potentially aversive stimuli in the sense of a changed top-down process of emotion avoidance. Thus, the current study provides further evidence that the disorder of anorexia nervosa is closely related to deficits in emotion processing in the early course of ontogenesis. Depressive symptoms might additionally trigger pathological behavior. Due to the small sample size, the data should be considered preliminary and require further validation. Level of evidence Level of evidence III: case–control study.
The Bewcastle Cauldron.
Creators: name: Davenport, J
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 96, 228-230
description: `Santon' type bronze cauldron, found during peat cutting on Black Moss, High Grains, Bewcastle (Cumbria) in 1907 and donated to Tullie House Museum in 1947. The Carlingwark Loch (D&G) cauldron is very similar in appearance but has a different rivetting method. Comparison with Urlingford (Co Kilkenny) cauldron and the Santon Downham (Suffolk) example is also made. Extensive repairs indicate a high value to its owners/users.
Note on a stone find from Lake Windermere.
Creators: name: King, Alan
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 96, 226-227
description: Greywacke or very fine-grained sandstone with finely pecked waist is here interpreted as a BA mining implement. Other similar finds may subsequently be re-interpreted.
Autoantibody targets in vaccine-associated narcolepsy
Creators: name: Häggmark-Månberg, Anna
name: Zandian, Arash
name: Forsström, Björn
name: Khademi, Mohsen
name: Izaura Lima Bomfim
name: Hellström, Cecilia
name: Lisen Arnheim-Dahlström
name: Hallböök, Tove
name: Darin, Niklas
name: Lundberg, Ingrid E.
name: Uhlén, Mathias
name: Partinen, Markku
name: Schwenk, Jochen M.
name: Olsson, Tomas
name: Nilsson, Peter
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Marine Biology
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Narcolepsy is a chronic sleep disorder with a yet unknown cause, but the specific loss of hypocretin-producing neurons together with a strong human leukocyte antigen (HLA) association has led to the hypothesis that autoimmune mechanisms might be involved. Here, we describe an extensive effort to profile autoimmunity repertoires in serum with the aim to find disease-related autoantigens. Initially, 57 serum samples from vaccine-associated and sporadic narcolepsy patients and controls were screened for IgG reactivity towards 10 846 fragments of human proteins using planar microarrays. The discovered differential reactivities were verified on suspension bead arrays in the same sample collection followed by further investigation of 14 antigens in 176 independent samples, including 57 narcolepsy patients. Among these 14 antigens, methyltransferase-like 22 (METTL22) and 5'-nucleotidase cytosolic IA (NT5C1A) were recognized at a higher frequency in narcolepsy patients of both sample sets. Upon sequence analysis of the 14 proteins, polymerase family, member 3 (PARP3), acyl-CoA-binding domain containing 7 (ARID4B), glutaminase 2 (GLS2) and cyclin-dependent kinase-like 1 (CDKL1) were found to contain amino acid sequences with homology to proteins found in the H1N1 vaccine. These findings could become useful elements of further clinical assays that aim towards a better phenotypic understanding of narcolepsy and its triggers.
Antiquities from Cumbria in West Midlands Museums.
Creators: name: Watson, Philip J
name: Symons, D J
Publisher: name: Archaeology Data Service
Year: 2002

description: Transactions of the Cumberland & Westmorland Antiquarian & Archaeological Society, 96, 223-226
description: `Prehistoric' by P J Watson (223--6) and `Roman' by D J Symons (226).
FAIRness of published data in life sciences, and opportunities to improve
Creators: name: Gobeill, Julien
name: Harrison, Melissa
name: Liberante, Fabio
name: Licata, Luana
name: Jeffryes, Matt
name: TURINA, MARIA PAOLA
name: Ruch, Patrick
Publisher: name: Zenodo
Year: 2025
Subjects: subject: Data Curation
subject: Information Storage and Retrieval
subject: Metadata
subject: FAIR Data Principles
subject: Open Access Publishing
subject: Persistent Identifiers
subject: Databases

description: This document represents a deliverable from ELIXIR’s 2024-28 Programme. It has been developed as part of the ELIXIR Data Platform in Work Package 4 on Scalable Curation. It was drafted by the Work Package members, with support from the ELIXIR Hub, and with input and feedback from ELIXIR members. 

This report examines each FAIR principle (Findability, Accessibility, Interoperability, and Reusability) in relation to the "long tail of data" in the life sciences, focusing on both published data and annotated publications. It highlights challenges in data sharing, persistent identifiers, metadata standards, and reuse practices. The report provides recommendations for funders, institutions, publishers, authors, curators and repositories to advance FAIR practices.
Clinico-genetic findings in 509 frontotemporal dementia patients
Creators: name: Wagner, Matias
name: Lorenz, Georg
name: Volk, Alexander E.
name: Brunet, Theresa
name: Edbauer, Dieter
name: Berutti, Riccardo
name: Zhao, Chen
name: Anderl-Straub, Sarah
name: Bertram, Lars
name: Danek, Adrian
name: Deschauer, Marcus
name: Dill, Veronika
name: Fassbender, Klaus
name: Fliessbach, Klaus
name: Götze, Katharina S.
name: Jahn, Holger
name: Kornhuber, Johannes
name: Landwehrmeyer, Bernhard
name: Lauer, Martin
name: Obrig, Hellmuth
name: Prudlo, Johannes
name: Schneider, Anja
name: Schroeter, Matthias L.
name: Uttner, Ingo
name: Vukovich, Ruth
name: Wiltfang, Jens
name: Winkler, Andrea S.
name: Zhou, Qihui
name: Ludolph, Albert C.
name: Consortium, The German FTLD
name: Oexle, Konrad
name: Otto, Markus
name: Diehl-Schmid, Janine
name: Winkelmann, Juliane
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Predictive markers
subject: Psychiatric disorders
subject: DDC 570 / Life sciences
subject: DDC 610 / Medicine & health
subject: Genetics
subject: FOS: Biological sciences
subject: Biomarkers
subject: Mental Disorders
subject: Genetik

description: Abstract Frontotemporal dementia (FTD) is a clinically and genetically heterogeneous disorder. To which extent genetic aberrations dictate clinical presentation remains elusive. We investigated the spectrum of genetic causes and assessed the genotype-driven differences in biomarker profiles, disease severity and clinical manifestation by recruiting 509 FTD patients from different centers of the German FTLD consortium where individuals were clinically assessed including biomarker analysis. Exome sequencing as well as C9orf72 repeat analysis were performed in all patients. These genetic analyses resulted in a diagnostic yield of 18.1%. Pathogenic variants in C9orf72 (n = 47), GRN (n = 26), MAPT (n = 11), TBK1 (n = 5), FUS (n = 1), TARDBP (n = 1), and CTSF (n = 1) were identified across all clinical subtypes of FTD. TBK1-associated FTD was frequent accounting for 5.4% of solved cases. Detection of a homozygous missense variant verified CTSF as an FTD gene. ABCA7 was identified as a candidate gene for monogenic FTD. The distribution of APOE alleles did not differ significantly between FTD patients and the average population. Male sex was weakly associated with clinical manifestation of the behavioral variant of FTD. Age of onset was lowest in MAPT patients. Further, high CSF neurofilament light chain levels were found to be related to GRN-associated FTD. Our study provides large-scale retrospective clinico-genetic data such as on disease manifestation and progression of FTD. These data will be relevant for counseling patients and their families.
In vitro evaluation of simulated stereotactic radiotherapy for wet age-related macular degeneration on three different cell lines
Creators: name: Vounotrypidis, Efstathios
name: Hillenmayer, Anna
name: Wertheimer, Christian M.
name: Athanasiou, Alexis
name: Siedlecki, Jakob
name: Orth, Michael
name: Ohlmann, Andreas
name: Priglinger, Siegfried G.
name: Wolf, Armin
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Diseases
subject: Medical research
subject: DDC 610 / Medicine & health

description: Abstract Low energy stereotactic radiotherapy has been proposed for the treatment of neovascular age related macular degeneration. We investigated the in vitro effect of the radiotherapy on pericytes, retinal pigment epithelium and endothelial cells. Primary human retinal pigment epithelium cells, human umbilical vein endothelial cells and human pericytes from Placenta were cultivated. In a pairwise protocol, one plate was irradiated at a dose of 16 Gy, while the second plate served as a non-irradiated control. Thereafter, cells were cultivated either in serum-free (non-permissive) or serum-stimulated (permissive) conditions. A life/dead assay, an XTT and a BrdU assay were performed up to 7 days after irradiation. No cell death occurred at any timepoint in any cell line after treatment nor in the control. Compared to the unirradiated controls, cell viability and metabolic activity were significantly reduced in irradiated cells in the XTT assay, except for non-permissive RPE cells. In the BrdU assay, proliferation was inhibited. While no cell death was detected in vitro, viability and proliferative capacity of all cell lines were significantly reduced. Therefore, it seems that low energy stereotactic radiotherapy inhibits angiogenesis without a direct induction of apoptosis but influencing microvascular function and stability.
The fin roundabout : Slit‐Robo and S1P signaling coordinate fin morphogenesis
Creators: name: Sehring, Ivonne M
name: Weidinger, Gilbert
Publisher: name: Universität Ulm
Year: 2022
Subjects: subject: DDC 570 / Life sciences
subject: Extremities (Anatomy)
subject: Mesenchymal stem cells
subject: Gliedmaßen

description: Development of vertebrate limbs and finsrequires that tissue growth is directedoutwards, away from the body. How suchdirected growth is achieved is a fascinat-ing biological problem. For limb/fin forma-tion and outgrowth, signaling betweenmesenchymal cells and the overlyingepithelium is essential. In particular, theepithelium at the distal margin of thegrowing limb/fin bud, termed the apicalectodermal ridge (AER), promotes directedoutgrowth of the underlying mesenchyme,e.g., by providing polarization cues formesenchymal cell migration. Several clas-sical signaling pathways, such as fibroblastgrowth factor (Fgf), hedgehog, and Wntsignaling, are involved in the regulation ofthe cellular events that shape the limb/finbud (Iovine,2007). In this issue ofEMBOReports, Carney and colleagues surpris-ingly find that the Slit-Robo pathway,which is best known for its function inaxon guidance, regulates the polarity ofdeveloping zebrafish fins (Mahabaleshwaretal,2007). Intriguingly, they identify anintricate back and forth of signals betweenthe mesenchyme and the AER. Slit ligandsderived from mesenchyme act on Roboreceptors in the AER to stimulate theproduction of sphingosine-1-phosphate,which then acts back on the mesenchymeto regulate cell polarity and orientation.
Additional file 2 of Dynamics of the infant gut microbiota in the first 18 months of life: the impact of maternal HIV infection and breastfeeding
Creators: name: Grant-Beurmann, Silvia
name: Jumare, Jibreel
name: Ndembi, Nicaise
name: Matthew, Olayemi
name: Shutt, Ashley
name: Omoigberale, Augustine
name: Martin, Olivia A.
name: Fraser, Claire M.
name: Charurat, Man
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1: Figure S1. Microbiota of 272 mother-infant pairs. Figure S2. Shannon diversity of 272 mother-infant pairs. Figure S3. PCoA of maternal microbiota based on HIV status. Figure S4. Shannon diversity of maternal microbiota based on HIV status. Figure S5. Maternal microbiota composition showed no significant differences based on HIV status. Figure S6. Number of breastfeeding and non-breastfeeding infants throughout the 18-month study period. Figure S7. PCoA of infant microbiomes based on HIV exposure, breastfeeding status, and time point. Figure S8. PCoA of infant microbiomes based on Bifidobacterium longum relative abundance, breastfeeding status, and time point. Figure S9. Shannon diversity of infant gut microbiota based on HIV exposure, breastfeeding status, and time point. Figure S10. Orthogonal partial least square discriminant analysis (OPLS_DA) and principal component analysis (PCA) of breast milk. Figure S11. Orthogonal partial least square discriminant analysis (OPLS_DA) and principal component analysis (PCA) of breast milk at six weeks postpartum and 6 months postpartum. Figure S12. Top 20 metabolites with highest Hotelling's T2 value. Table S1. Sample collection schedule. Table S2. Two-way repeated measures analysis of variance (ANOVA) of breast milk metabolites.
Using a Telegram chatbot as cost-effective software infrastructure for ambulatory assessment studies with iOS and Android devices
Creators: name: Barthelmäs, Michael
name: Killinger, Marcel
name: Keller, Johannes
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Ambulatory assessment
subject: DDC 150 / Psychology
subject: DDC 300 / Social sciences
subject: Chatbots
subject: Python (Computer program language)
subject: Telegram
subject: Chatbot
subject: Open Source
subject: Python 3.0

description: In this work, we present an innovative and cost-effective approach to run ambulatory assessment (AA) studies on participants’ smartphones via Telegram Messenger. Our approach works both for Android and iOS devices. The population of potential participants in a given country or region consists of all individuals who (a) are in possession of a smartphone, (b) are willing to install Telegram Messenger, and (c) live in an environment providing constant connection to the Internet. In our new approach to AA, participants are asked to subscribe to a Telegram chatbot that provides them with links to brief surveys at specified points in time in their everyday lives via short notifications. We developed a user-friendly Python script that allows for the flexible editing of the chatbot’s settings, e.g., the number of surveys per day. All common survey software designed for mobile devices can be used to present surveys to participants. This means that data collection takes place exclusively via the selected survey software, not via Telegram. With our approach, AA studies can be carried out among iOS and Android users cost-effectively and reliably while data security is ensured. Initial data from a pilot study show that studies of this kind are feasible, and the procedure is accepted by participants. Our Python script is licensed under General Public License (GPLv3) and therefore freely available and editable: https://github.com/Raze97/Telegram-Survey-Bot
Arthropod spatial cognition
Creators: name: Pfeffer, Sarah
name: Wolf, Harald
Publisher: name: Universität Ulm
Year: 2020
Subjects: subject: Arthropods
subject: Spatial cognition
subject: Comparative approach
subject: DDC 570 / Life sciences
subject: DDC 590 / Animals (Zoology)
subject: Arthropoda
subject: Animal orientation
subject: Gliederfüßer
subject: Navigation
subject: Orientierung

description: The feats of arthropods, and of the well-studied insects and crustaceans in particular, have fascinated scientists and laymen alike for centuries. Arthropods show a diverse repertoire of cognitive feats, of often unexpected sophistication. Despite their smaller brains and resulting lower neuronal capacity, the cognitive abilities of arthropods are comparable to, or may even exceed, those of vertebrates, depending on the species compared. Miniature brains often provide parsimonious but smart solutions for complex behaviours or ecologically relevant problems. This makes arthropods inspiring subjects for basic research, bionics, and robotics. Investigations of arthropod spatial cognition have originally concentrated on the honeybee, an animal domesticated for several thousand years. Bees are easy to keep and handle, making this species amenable to experimental study. However, there are an estimated 5–10 million arthropod species worldwide, with a broad diversity of lifestyles, ecology, and cognitive abilities. This high diversity provides ample opportunity for comparative analyses. Comparative study, rather than focusing on single model species, is well suited to scrutinise the link between ecological niche, lifestyle, and cognitive competence. It also allows the discovery of general concepts that are transferable between distantly related groups of organisms. With species diversity and a comparative approach in mind, this special issue compiles four review articles and ten original research reports from a spectrum of arthropod species. These contributions range from the well-studied hymenopterans, and ants in particular, to chelicerates and crustaceans. They thus present a broad spectrum of glimpses into current research on arthropod spatial cognition, and together they cogently emphasise the merits of research into arthropod cognitive achievements.
The case of a glomus tumour
Creators: name: George, Christina
name: Rai, Sweta
name: Diaz-Cano, Salvador J.
name: Creamer, Daniel
Publisher: name: figshare
Year: 2016
Subjects: subject: 110304 Dermatology
subject: FOS: Clinical medicine
subject: 110316 Pathology (excl. Oral Pathology)

description: A 46 year old man presented to the dermatology clinic with a seven year history of intermittent pain under the fingernail of his left fourth proximal digit that was noticeably exacerbated by cold weather. Examination revealed a tender and subtle 3 mm circular dusky blue lesion under the nail (fig 1⇓). This was excised and histologically confirmed as a glomus tumour. This is a rare smooth muscle neoplasm, most common in subungual sites and the fingers and toes. It arises from the glomus body—a thermoregulatory component in the dermis. This diagnosis can be made on history alone: a subungual lesion with pain induced by cold is pathognomonic of glomus tumour. Treatment is by excision of the tumour.
Managing admission and discharge processes in intensive care units
Creators: name: Bai, Jie
name: Fügener, Andreas
name: Gönsch, Jochen
name: Brunner, Jens O.
name: Blobner, Manfred
Publisher: name: Universität Ulm
Year: 2021
Subjects: subject: Intensive care unit
subject: Admission and discharge decisions
subject: Markov decision process
subject: Dynamic programming
subject: Operations research
subject: CRITICALLY-ILL PATIENTS
subject: ICU ADMISSION
subject: CAPACITY MANAGEMENT
subject: DELAYED ADMISSION
subject: ELECTIVE-SURGERY
subject: TRIAGE
subject: OPERATIONS
subject: DECISIONS
subject: MODEL
subject: ALLOCATION
subject: DDC 610 / Medicine & health
subject: Intensive care units
subject: Intensivstation

description: Abstract The intensive care unit (ICU) is one of the most crucial and expensive resources in a health care system. While high fixed costs usually lead to tight capacities, shortages have severe consequences. Thus, various challenging issues exist: When should an ICU admit or reject arriving patients in general? Should ICUs always be able to admit critical patients or rather focus on high utilization? On an operational level, both admission control of arriving patients and demand-driven early discharge of currently residing patients are decision variables and should be considered simultaneously. This paper discusses the trade-off between medical and monetary goals when managing intensive care units by modeling the problem as a Markov decision process. Intuitive, myopic rule mimicking decision-making in practice is applied as a benchmark. In a numerical study based on real-world data, we demonstrate that the medical results deteriorate dramatically when focusing on monetary goals only, and vice versa. Using our model, we illustrate the trade-off along an efficiency frontier that accounts for all combinations of medical and monetary goals. Coming from a solution that optimizes monetary costs, a significant reduction of expected mortality can be achieved at little additional monetary cost.
Additional file 16 of Reconstructing an historical pollination syndrome: keel flowers
Creators: name: Uluer, Deniz Aygören
name: Forest, Félix
name: Armbruster, Scott
name: Hawkins, Julie A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 16. S16. Sources used to construct ancestral state analyses of Fabales.
Additional file 1 of Reconstructing an historical pollination syndrome: keel flowers
Creators: name: Uluer, Deniz Aygören
name: Forest, Félix
name: Armbruster, Scott
name: Hawkins, Julie A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1. S1. Chronogram of Fabales.