cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Domain Enhanced Arbitrary Image Style Transfer via Contrastive Learning
Creators: name: Zhang, Yuxin
name: Tang, Fan
name: Dong, Weiming
name: Huang, Haibin
name: Ma, Chongyang
name: Lee, Tong-Yee
name: Xu, Changsheng
Publisher: name: arXiv
Year: 2022
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Graphics (cs.GR)
subject: FOS: Computer and information sciences

description: In this work, we tackle the challenging problem of arbitrary image style transfer using a novel style feature representation learning method. A suitable style representation, as a key component in image stylization tasks, is essential to achieve satisfactory results. Existing deep neural network based approaches achieve reasonable results with the guidance from second-order statistics such as Gram matrix of content features. However, they do not leverage sufficient style information, which results in artifacts such as local distortions and style inconsistency. To address these issues, we propose to learn style representation directly from image features instead of their second-order statistics, by analyzing the similarities and differences between multiple styles and considering the style distribution. Specifically, we present Contrastive Arbitrary Style Transfer (CAST), which is a new style representation learning and style transfer method via contrastive learning. Our framework consists of three key components, i.e., a multi-layer style projector for style code encoding, a domain enhancement module for effective learning of style distribution, and a generative network for image style transfer. We conduct qualitative and quantitative evaluations comprehensively to demonstrate that our approach achieves significantly better results compared to those obtained via state-of-the-art methods. Code and models are available at https://github.com/zyxElsa/CAST_pytorch
description: Accepted by SIGGRAPH 2022
Fully irreducible Automorphisms of the Free Group via Dehn twisting in $\sharp_k(S^2 \times S^1)$
Creators: name: Gültepe, Funda
Publisher: name: arXiv
Year: 2014
Subjects: subject: Group Theory (math.GR)
subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: Primary 20F65, Secondary 57M

description: By using a notion of a geometric Dehn twist in $\sharp_k(S^2 \times S^1)$, we prove that when projections of two $\mathbb{Z}$-splittings to the free factor complex are far enough from each other in the free factor complex, Dehn twist automorphisms corresponding to the $\mathbb{Z}$-splittings generate a free group of rank $2$. Moreover, every element from this free group is either conjugate to a power of one of the Dehn twists or it is a fully irreducible outer automorphism of the free group. We also prove that, when projected to the intersection graph, the same group of Dehn twists produce atoroidal fully irreducible automorphisms.
description: 23 pages, 7 figures. Latest version accepted to AGT
Resonant phonon-magnon interactions in free-standing metal-ferromagnet multilayer structures
Creators: name: Vernik, Urban
name: Lomonosov, Alexey M.
name: Vlasov, Vladimir S.
name: Kotov, Leonid N.
name: Kuzmin, Dmitry A.
name: Bychkov, Igor V.
name: Vavassori, Paolo
name: Temnov, Vasily V.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: We analyze resonant magneto-elastic interactions between standing perpendicular spin wave modes (exchange magnons) and longitudinal acoustic phonon modes in free-standing hybrid metal-ferromagnet bilayer and trilayer structures. Whereas the ferromagnetic layer acts as a magnetic cavity, all metal layers control the frequencies and eigenmodes of acoustic vibrations. The here proposed design allows for achieving and tuning the spectral and spatial modes overlap between phonons and magnons that results in their strong resonant interaction. Realistic simulations for gold-nickel multilayers show that sweeping the external magnetic field should allow for observing resonantly enhanced interactions between individual magnon and phonon modes in a broad range of frequencies spanning from tens of GHz up to several hundreds of GHz, which can be finely tuned through the multilayer design. Our results would enable the systematic study and the deep understanding of resonantly enhanced magneto-elastic coupling between individual phonon and magnon modes up to frequencies of great contemporary fundamental and applied interest.
description: 9 pages, 6 figures
Phytochemical group test and pharmacological investigations of Persicaria barbata (L.) H. Hara
Creators: name: Bhuia, Md. Shimul
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 310110
subject: Receptors and membrane biology

description: Traditionally, various parts of Persicaria barbata (family: Polygonaceae) are used in many countries in eastern South Asia. This study evaluates the phytochemical groups and pharmacological activities of the aerial parts of P. barbata. For this, extraction was done with ethanol and fractioned with chloroform and n-hexane. Preliminary chemical groups, DPPH scavenging, egg albumin denaturation, and disc diffusion assays were performed for phytochemical, antioxidant, anti-inflammatory, and anti-bacterial activity screening, respectively. In vivo anti-diarrheal, analgesic, and anti-pyretic activity screening was done by applying the castor oil-induced diarrheal model, the hot plate test, and the yeast-induced pyrexia model, respectively. Additionally, open-field and swing test models were used to assess in vivo anxiolytic activity. The phytochemical study suggests that P. barbata possesses alkaloids, steroids, glycosides, flavonoids, tannins, gums, and saponins. The hydro-ethanol extract showed concentration-dependent DPPH radical scavenging and inhibition of protein denaturation capacity. It also showed moderate (zone of inhibition ranging from 9 to 16 mm) but broad-spectrum anti-bacterial effects against L. casei, L. coryniformis, B. cereus, S. aureus, P. azotoformis, E. coli, P. aeruginosa, and K. pneumonia. Moreover, all the extracts also showed significant anti-diarrheal, analgesic, anxiolytic, and antipyretic effects in Swiss albino mice. In conclusion, P. barbata might be a good source of phytotherapeutic agents. Further extensive investigations should be conducted to isolate and distinguish the active principles of this plant and to interpret the exact mechanism of each action.
Respiratory Viral Infections in Lung Transplant Recipients: Implications for Long Term Outcomes and Emerging Therapies
Creators: name: Hage C.
name: van Duin D.
name: Coakley R.
name: Lobo L.J.
name: Krishnan S.
Publisher: name: LIDSEN Publishing Inc
Year: 2019

description: Lung transplant recipients are at greater risk of respiratory viral infections as compared to other solid organ transplant recipients due to constant exposure of the allograft to the external environment. There are no standardized methods for surveillance, prevention, or treatment of these infections despite their association with increased morbidity and mortality. Various studies have linked respiratory viral infections with acute cellular rejection and chronic allograft dysfunction, and emerging data indicates a role in antibody mediated rejection. This paper will review the prevalence and impact of community acquired respiratory viruses in lung transplant recipients, review the evidence linking these viral infections to long term graft dysfunction and rejection, describe existing strategies for surveillance and prevention, and list the currently available, and promising investigational therapies.
Effects of Crystalline Disorder on Interfacial and Magnetic Properties of Sputtered Topological Insulator/Ferromagnet Heterostructures
Creators: name: Bhattacharjee, Nirjhar
name: Mahalingam, Krishnamurthy
name: Fedorko, Adrian
name: Will-Cole, Alexandria
name: Ryu, Jaehyeon
name: Page, Michael
name: McConney, Michael
name: Fang, Hui
name: Heiman, Don
name: Sun, Nian Xiang
Publisher: name: arXiv
Year: 2022
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Thin films of Topological insulators (TIs) coupled with ferromagnets (FMs) are excellent candidates for energy-efficient spintronics devices. Here, the effect of crystalline structural disorder of TI on interfacial and magnetic properties of sputter-deposited TI/FM, Bi2Te3/Ni80Fe20, heterostructures is reported. Ni and a smaller amount of Fe from Py was found to diffuse across the interface and react with Bi2Te3. For highly crystalline c-axis oriented Bi2Te3 films, a giant enhancement in Gilbert damping is observed, accompanied by an effective out-of-plane magnetic anisotropy and enhanced damping-like spin-orbit torque (DL-SOT), possibly due to the topological surface states (TSS) of Bi2Te3. Furthermore, a spontaneous exchange bias is observed in hysteresis loop measurements at low temperatures. This is because of an antiferromagnetic topological interfacial layer formed by reaction of the diffused Ni with Bi2Te3 which couples with the FM, Ni80Fe20. For increasing disorder of Bi2Te3, a significant weakening of exchange interaction in the AFM interfacial layer is found. These experimental results Abstract length is one paragraph.
Polarization switching induced by domain wall sliding in two-dimensional ferroelectric monochalcogenides
Creators: name: Petralanda, Urko
name: Olsen, Thomas
Publisher: name: arXiv
Year: 2022
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The ability to switch between distinct states of polarization comprises the defining property of ferroelectrics. However, the microscopic mechanism responsible for switching is not well understood and theoretical estimates based on coherent monodomain switching typically overestimate experimentally determined coercive fields by orders of magnitude. In this work we present a detailed first principles characterization of domain walls (DWs) in two-dimensional ferroelectric GeS, GeSe, SnS and SnSe. In particular, we calculate the formation energies and migration barriers for 180 and 90 DWs, and then derive a general expression for the coercive field assuming that polarization switching is mediated by DW migration. We apply our approach to the materials studied and obtain good agreement with experimental coercive fields. The calculated coercive fields are up to two orders of magnitude smaller than those predicted from coherent monodomain switching in GeSe, SnS and SnSe. Finally, we study the optical properties of the compounds and find that the presence of 180 DWs leads to a significant red shift of the absorption spectrum, implying that the density of DWs may be determined by means of simple optical probes.
description: 14 pages, 6 figures
Albia (Anchistalbia) suvarna Cook 1967
Creators: name: Pešić, Vladimir
name: Chatterjee, Tapas
name: Bordoloi, Sabitry
Publisher: name: Zenodo
Year: 2010
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Axonopsidae
Albia
Albia suvarna

description: Albia (Anchistalbia) suvarna Cook, 1967
Records from the study area: Kerala—Cook (1967); Prasad (1974).
Habitat: Mountain streams.
Distribution: India.
description: Published as part of Pešić, Vladimir, Chatterjee, Tapas & Bordoloi, Sabitry, 2010, A checklist of the water mites (Acari: Hydrachnidia) of India, with new records and description of one new species, pp. 1-54 in Zootaxa 2617 (1) on page 17, DOI: 10.11646/zootaxa.2617.1.1, http://zenodo.org/record/197964
Properties and examples of Faber--Walsh polynomials
Creators: name: Sète, Olivier
name: Liesen, Jörg
Publisher: name: arXiv
Year: 2015
Subjects: subject: Complex Variables (math.CV)
subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 30C10, 30E10, 30C20

description: The Faber--Walsh polynomials are a direct generalization of the (classical) Faber polynomials from simply connected sets to sets with several simply connected components. In this paper we derive new properties of the Faber--Walsh polynomials, where we focus on results of interest in numerical linear algebra, and on the relation between the Faber--Walsh polynomials and the classical Faber and Chebyshev polynomials. Moreover, we present examples of Faber--Walsh polynomials for two real intervals as well as some non-real sets consisting of several simply connected components.
description: Minor rewording in Section 3, which now explicitly mentions the Bernstein-Walsh inequality
Additional file 1 of Health-related quality of life in patients with inoperable malignant bowel obstruction: secondary outcome from a double-blind, parallel, placebo-controlled randomised trial of octreotide
Creators: name: McCaffrey, Nikki
name: Asser, Tegan
name: Fazekas, Belinda
name: Muircroft, Wendy
name: Agar, Meera
name: Clark, Katherine
name: Eckermann, Simon
name: Lee, Jessica
name: Rohit Joshi
name: Allcroft, Peter
name: Sheehan, Caitlin
name: Currow, David C.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Table A1. Baseline and post-treatment EORTC QLQ-C15-PAL mean scores (multiple imputation). Baseline and post-treatment EORTC QLQ-C15-PAL mean scores for completed items and multiple imputation.
Additional file 1: of The long-term survival characteristics of a cohort of colorectal cancer patients and baseline variables associated with survival outcomes with or without time-varying effects
Creators: name: Yajun Yu
name: Carey, Megan
name: Pollett, William
name: Green, Jane
name: Dicks, Elizabeth
name: Parfrey, Patrick
name: Yildiz Yilmaz
name: Savas, Sevtap
Publisher: name: Figshare
Year: 2019
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Figure S1. Kaplan-Meier curves for the variables with a p value
Combined Medical and Surgical Management of Hepatic Mucormycosis in an Adult with Acute Myeloid Leukemia: Case Report and Review of the Literature
Creators: name: Shah M.
name: Van Duin D.
name: Gerber D.A.
name: Almansouri A.
name: Nel J.
Publisher: name: Springer Netherlands
Year: 2019

description: Hepatic mucormycosis is a disease caused by a ubiquitous fungus which is especially important in patients with hematologic malignancies. We present a case of an adult patient with acute myeloid leukemia who developed the infection after undergoing chemotherapy. His successful management was an integrated approach of a minimally invasive surgical resection with anti-fungal therapy. We describe the management of this patient and a review of the literature.
The pharmacokinetics of dabigatran in a rat model of hyperlipidemia induced by poloxamer 407
Creators: name: Kim, Ji Hyeon
name: Baek, Eugene
name: Kang, Hee Eun
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Physiology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Mental Health

description: Various pharmacokinetic changes have been reported in experimental hyperlipidemic (HL) animal models. To evaluate whether P-glycoprotein (P-gp) activity was affected in HL rats, we assessed the pharmacokinetics of dabigatran after oral administration of dabigatran etexilate (DABE); this is a dabigatran prodrug and a well-known P-gp substrate. HL and control rats exhibited similar area under the plasma concentration-time curve (AUC), total body clearance (CL), and steady state volume of distribution (Vss) values following intravenous administration of dabigatran (1 mg/kg). This suggested that the distribution and elimination of dabigatran were similar in control and HL rats. The hepatic and intestinal P-gp protein levels did not differ significantly between control and HL rats. The dabigatran AUC and extent of absolute oral bioavailability (F) values were similar in control and HL rats following oral administration of DABE (10 mg/kg as dabigatran). Therefore, there was no apparent change in intestinal P-gp activity in HL rats compared to control rats. This study revealed no significant change in P-gp expression or activity in the intestine or liver of HL rats, and similar pharmacokinetics of dabigatran. Hyperlipidemia may not directly affect the oral absorption of P-gp substrate drugs.
Exponential Varieties
Creators: name: Michałek, Mateusz
name: Sturmfels, Bernd
name: Uhler, Caroline
name: Zwiernik, Piotr
Publisher: name: arXiv
Year: 2014
Subjects: subject: Algebraic Geometry (math.AG)
subject: Statistics Theory (math.ST)
subject: FOS: Mathematics

description: Exponential varieties arise from exponential families in statistics. These real algebraic varieties have strong positivity and convexity properties, familiar from toric varieties and their moment maps. Among them are varieties of inverses of symmetric matrices satisfying linear constraints. This class includes Gaussian graphical models. We develop a general theory of exponential varieties. These are derived from hyperbolic polynomials and their integral representations. We compare the multidegrees and ML degrees of the gradient map for hyperbolic polynomials.
Fingering convection in the stably-stratified layers of planetary cores
Creators: name: Guervilly, Celine
Publisher: name: arXiv
Year: 2022
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Fluid Dynamics (physics.flu-dyn)
subject: Geophysics (physics.geo-ph)
subject: FOS: Physical sciences

description: Stably-stratified layers may be present at the top of the electrically-conducting fluid layers of many planets either because the temperature gradient is locally subadiabatic or because a stable composition gradient is maintained by the segregation of chemical elements. Here we study the double-diffusive processes taking place in such a stable layer, considering the case of Mercury's core where the temperature gradient is stable but the composition gradient is unstable over a 800km-thick layer. The large difference in the molecular diffusivities leads to the development of buoyancy-driven instabilities that drive radial flows known as fingering convection. We model fingering convection using hydrodynamical simulations in a rotating spherical shell and varying the rotation rate and the stratification strength. For small Rayleigh numbers (i.e. weak background temperature and composition gradients), fingering convection takes the form of columnar flows aligned with the rotation axis and with an azimuthal size comparable with the layer thickness. For larger Rayleigh numbers, the flows retain a columnar structure but the azimuthal size is drastically reduced leading to thin sheet-like structures that are elongated in the meridional direction. The azimuthal length decreases when the thermal stratification increases, following closely the scaling law expected from the linear non-rotating planar theory (Stern, 1960). We find that the radial flows always remain laminar with local Reynolds number of order 1-10. Equatorially-symmetric zonal flows form due to latitudinal variations of the axisymmetric composition. The zonal velocity exceeds the non-axisymmetric velocities at the largest Rayleigh numbers. We discuss plausible implications for planetary magnetic fields.
description: accepted for publication in JGR: Planets
Additional file 1 of Pharmacist and patient perspectives on recruitment strategies for randomized controlled trials: a qualitative analysis
Creators: name: Fletcher, Jane M.
name: Saunders-Smith, Terry
name: Manns, Braden J.
name: Tsuyuki, Ross
name: Hemmelgarn, Brenda R.
name: Tonelli, Marcello
name: Campbell, David J. T.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: Sociology
subject: FOS: Sociology
subject: Science Policy

description: Additional file 1. Interview Guide - Assessing outcomes of enhanced Chronic disease Care through patient Education and a value-baSed formulary Study (ACCESS).
Stranger than Metals
Creators: name: Phillips, Philip W.
name: Hussey, Nigel E.
name: Abbamonte, Peter
Publisher: name: arXiv
Year: 2022
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Although the resistivity in traditional metals increases with temperature, its $T$ dependence vanishes at low or high temperature, albeit for different reasons. Here, we review a class of materials, known as \lq strange' metals, that can violate both principles. In materials exhibiting such behavior, the change in slope of the resistivity as the mean free path drops below the lattice constant, or as $T \rightarrow 0$, can be imperceptible, suggesting complete continuity between the charge carriers at low and high $T$. Since particles cannot scatter at length scales shorter than the interatomic spacing, strange metallicity calls into question the relevance of locality and a particle picture of the underlying current. This review focuses on transport and spectroscopic data on candidate strange metals with an eye to isolate and identify a unifying physical principle. Special attention is paid to quantum criticality, Planckian dissipation, Mottness, and whether a new gauge principle, which has a clear experimental signature, is needed to account for the non-local transport seen in strange metals. For the cuprates, strange metallicity is shown to track the superfluid density, thereby making a theory of this state the primary hurdle in solving the riddle of high-temperature superconductivity.
description: Accepted in Science (as a Review on Strange Metals), 4 figures, 2 tables
Phytochemical group test and pharmacological investigations of Persicaria barbata (L.) H. Hara
Creators: name: Bhuia, Md. Shimul
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 310110
subject: Receptors and membrane biology

description: Traditionally, various parts of Persicaria barbata (family: Polygonaceae) are used in many countries in eastern South Asia. This study evaluates the phytochemical groups and pharmacological activities of the aerial parts of P. barbata. For this, extraction was done with ethanol and fractioned with chloroform and n-hexane. Preliminary chemical groups, DPPH scavenging, egg albumin denaturation, and disc diffusion assays were performed for phytochemical, antioxidant, anti-inflammatory, and anti-bacterial activity screening, respectively. In vivo anti-diarrheal, analgesic, and anti-pyretic activity screening was done by applying the castor oil-induced diarrheal model, the hot plate test, and the yeast-induced pyrexia model, respectively. Additionally, open-field and swing test models were used to assess in vivo anxiolytic activity. The phytochemical study suggests that P. barbata possesses alkaloids, steroids, glycosides, flavonoids, tannins, gums, and saponins. The hydro-ethanol extract showed concentration-dependent DPPH radical scavenging and inhibition of protein denaturation capacity. It also showed moderate (zone of inhibition ranging from 9 to 16 mm) but broad-spectrum anti-bacterial effects against L. casei, L. coryniformis, B. cereus, S. aureus, P. azotoformis, E. coli, P. aeruginosa, and K. pneumonia. Moreover, all the extracts also showed significant anti-diarrheal, analgesic, anxiolytic, and antipyretic effects in Swiss albino mice. In conclusion, P. barbata might be a good source of phytotherapeutic agents. Further extensive investigations should be conducted to isolate and distinguish the active principles of this plant and to interpret the exact mechanism of each action.
Relebactam is a potent inhibitor of the kpc-2 -lactamase and restores imipenem susceptibility in kpc-producing enterobacteriaceae
Creators: name: Alsop J.
name: Taracila M.A.
name: Kreiswirth B.N.
name: Bethel C.R.
name: Kaye K.S.
name: Barnes M.D.
name: Papp-Wallace K.M.
name: Becka S.A.
name: van Duin D.
name: Bonomo R.A.
Publisher: name: American Society for Microbiology
Year: 2018

description: The imipenem-relebactam combination is in development as a potential treatment regimen for infections caused by Enterobacteriaceae possessing complex -lactamase backgrounds. Relebactam is a -lactamase inhibitor that possesses the diazabicyclooctane core, as in avibactam; however, the R1 side chain of relebactam also includes a piperidine ring, whereas that of avibactam is a carboxyamide. Here, we investigated the inactivation of the Klebsiella pneumoniae carbapenemase KPC-2, the most widespread class A carbapenemase, by relebactam and performed susceptibility testing with imipenem-relebactam using KPC-producing clinical isolates of Enterobacteriaceae. MIC measurements using agar dilution methods revealed that all 101 clinical isolates of KPC-producing Enterobacteriaceae (K. pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii, Citrobacter koseri, and Escherichia coli) were highly susceptible to imipenem-relebactam (MICs 2 mg/liter). Relebactam inhibited KPC-2 with a second-order onset of acylation rate constant (k2/K) value of 24,750 M1 s1 and demonstrated a slow off-rate constant (koff) of 0.0002 s1. Biochemical analysis using time-based mass spectrometry to map intermediates revealed that the KPC-2–relebactam acyl-enzyme complex was stable for up to 24 h. Importantly, desulfation of relebactam was not observed using mass spectrometry. Desulfation and subsequent deacylation have been observed during the reaction of KPC-2 with avibactam. Upon molecular dynamics simulations of relebactam in the KPC-2 active site, we found that the positioning of active-site water molecules is less favorable for desulfation in the KPC-2 active site than it is in the KPC-2–avibactam complex. In the acyl complexes, the water molecules are within 2.5 to 3 Å of the avibactam sulfate; however, they are more than 5 to 6 Å from the relebactam sulfate. As a result, we propose that the KPC-2–relebactam acyl complex is more stable than the KPC-2–avibactam complex. The clinical implications of this difference are not currently known.
Characterization and depositional pattern of the modern pollen and non-pollen palynomorphs in Pobitora Wildlife Sanctuary, India and its implications to palaeoecology and palaeoherbivory analysis
Creators: name: Vaish, Siddhant
name: Arya, Ajay K.
name: Basumatary, Sadhan K.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: This study documents the depositional pattern of modern pollen and fungal spores in relation to the different vegetation types and wildlife activities in Pobitora Wildlife Sanctuary located in northeast India. The pollen data accurately matches the extant vegetation types and provides additional evidence on the representation and relative abundance of the major pollen taxa in the pollen assemblages. Forest habitat is characterized by the abundance of Bombax, Lagerstroemia, Barringtonia, and Albizia pollen in the pollen assemblage. The swamp habitat is characterized by a Cyperaceae, Onagraceae, Nymphaea, and Potamogeton the grassland habitat characterized by the dominance of non-cereal (Poaceae), Asteroideae, Cyperaceae, and Bombax pollen in the pollen assemblage. Among fungal spores, coprophilous fungal spores were observed and identified. Their presence varies in relation to the different vegetation types and level of wildlife activity in each habitat in the wildlife sanctuary. Rhododendron pollen in the palynoassemblages is indicative of seasonal flooding during periods of high rainfall in and around the study areas. Principal Component Analysis (PCA) applied to the quantified data obtained from the pollen frequency analyses revealed a significant variation that distinguished the three different vegetation types in the Pobitora Wildlife Sanctuary. This modern pollen and fungal spore data serves as a reliable baseline for the reconstruction of the palaeoecology and palaeoherbivory in the Pobitora Wildlife Sanctuary and to correlate the types of vegetation present in other parts of the tropical region of Indo-Burma.
Additional file 1: of Variable retention forestry in European boreal forests in Russia
Creators: name: Shorohova, Ekaterina
name: Sinkevich, Sergey
name: Kryshen, Aleksandr
name: Vanha-Majamaa, Ilkka
Publisher: name: Figshare
Year: 2019
Subjects: subject: Molecular Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology

description: References in the Russian language. (DOCX 27 kb)
Evaluation of Sensititre Broth Microdilution Plate for determining the susceptibility of carbapenem-resistant Klebsiella pneumoniae to polymyxins
Creators: name: Karichu J.
name: Cober E.
name: Hujer K.M.
name: Otiso J.
name: Salata R.
name: Domitrovic T.N.
name: Bonomo R.A.
name: Marshall S.
name: Hujer A.M.
name: Rudin S.D.
name: Van Duin D.
name: Kaye K.S.
name: Van Heule H.
name: Rojas L.J.
name: Perez F.
name: Keller G.
name: Richter S.S.
Publisher: name: Elsevier Inc.
Year: 2018

description: Colistin and polymyxin B MICs were determined for 106 carbapenem-resistant Klebsiella pneumoniae (CR-Kp) isolates using Sensititre Research Use Only GNX2F plates (Thermo Fisher) and compared to CLSI broth macrodilution (BMD) as the reference method. For colistin, EUCAST breakpoints were applied and testing of isolates with very major (VM) errors was repeated in duplicate by both methods to determine a majority result. Essential agreement (MIC ± one dilution) of GNX2F with the reference method was 97.1% for polymyxin B and 92.5% for colistin (7 VM errors, 22.6%). After discrepancy testing, there were 28 colistin resistant isolates by BMD and essential agreement was 94.3% with 4 VM errors (14.3%). Colistin and polymyxin B GNX2F results showed acceptable essential agreement with BMD for MICS without interpretation. Colistin VM errors with EUCAST breakpoints were due to MIC variability in the 2 to 4 μg/mL range that could be addressed by establishing an intermediate category.
Ergodic Achievable Rate Maximization of RIS-assisted Millimeter-Wave MIMO-OFDM Communication Systems
Creators: name: Li, Renwang
name: Sun, Shu
name: Tao, Meixia
Publisher: name: arXiv
Year: 2022
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: Reconfigurable intelligent surface (RIS) has attracted extensive attention in recent years. However, most research focuses on the scenario of the narrowband and/or instantaneous channel state information (CSI), while wide bandwidth with the use of millimeter-wave (mmWave) (including sub-Terahertz) spectrum is a major trend in next-generation wireless communications, and statistical CSI is more practical to obtain in realistic systems. Thus, we {consider} the ergodic achievable rate of RIS-assisted mmWave multiple-input multiple-output orthogonal frequency division multiplexing communication systems. The widely used Saleh-Valenzuela channel model is adopted to characterize the mmWave channels and only the statistical CSI is available. We first derive the approximations of the ergodic achievable rate by means of the majorization theory and Jensen's inequality. Then, an alternating optimization based algorithm is proposed to maximize the ergodic achievable rate by jointly designing the transmit covariance matrix at the base station and the reflection coefficients at the RIS. Specifically, the design of the transmit covariance matrix is transformed into a power allocation problem and solved by spatial-frequency water-filling. The reflection coefficients are optimized by the Riemannian conjugate gradient algorithm. Simulation results corroborate the effectiveness of the proposed algorithms.
description: submitted for possible publication. in IEEE Transactions on Wireless Communications, 2022
DRUG DESIGN AND DEVELOPMENT OF ALECTINIB AGAINST ALK PROTEIN DOMAIN FOR TREATMENT OF LUNG CANCER: AN IN-SILICO APPROACH
Creators: name: Bhuia, Md. Shimul
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 310101
subject: Analytical biochemistry

description: Alectinib (D) is an inhibitor of anaplastic lymphoma kinase (ALK) and approved by the USFDA for the treatment of non-small cell lung cancer (NSCLC). This study aims to develop & design new Alectinib derivatives which can be capable to inhibit more potently the activity of kinases other than ALK and better in pharmacokinetics than the parent drug in the treatment of NSCLC. The derivatives of Alectinib have been designed by using density functional theory (DFT) and the inhibitory performance of drugs was also explored by molecular docking study. We have investigated frontier molecular orbital features (HOMO, LUMO, gap, hardness, and softness), electrostatic potential, dipole moment and thermodynamic properties (electronic energy, enthalpy, Gibb’s free energy) of all the optimized drugs. The screening of the designed drugs (D-F, D-Cl, D-Br, D-CF3, D-OCH3, D-NH2) has been performed against ALK, RET, KDR, and KIT crystal structure of proteins. In our findings, the modified derivatives D-F and D-Cl revealed higher binding affinity -11.2 & -11.1 against ALK (PDB ID: 4TT7) respectively, where the parent drug showed binding affinity -10 against the same protein. The pharmacokinetic properties & toxicity of all drugs were predicted by preADMET, admetSAR@LMMD online database and MedChem designer. It assured that all the drugs are thermodynamically stable; some of them are more chemically reactive. In our computational investigation, we found that D-F & D-Cl are more potent inhibitors against ALK for the treatment of NSCLC than the parent drug. Finally, this study can be helpful for the design and development of new ALK inhibitors
China-United States Research Collaborations in Antimicrobial Resistance
Creators: name: Li L.
name: Wang M.
name: Zhang F.
name: Gu P.
name: Dong J.
name: Cao B.
name: Evans B.
name: Liu Z.
name: Yu Y.
name: Pfaff M.
name: Fowler V.G.
name: van Duin D.
name: Arias R.M.
Publisher: name: Oxford University Press
Year: 2018

description: A strong synergy can result from China-US antimicrobial resistance (AMR) collaborations given similarities and differences between their respective healthcare systems and research infrastructures. The Antibacterial Resistance Leadership Group has employed a model of realistic growth, starting with a feasible, relatively low-resource observational study in a critical priority pathogen. This and other observational studies will provide vital scientific information required for the rational design of future interventional trials. In addition, it provides a mutual, low-risk opportunity for determining the strengths and opportunities of the research collaboration. Issues identified during the observational studies can be addressed prior to the initiation of high-resource interventional studies. Collaborative clinical AMR studies between China and the United States have tremendous potential to decrease AMR rates, improve responsible antibiotic use, and ultimately improve the lives of patients in both countries.
New test of the FLRW metric using the distance sum rule
Creators: name: Rasanen, Syksy
name: Bolejko, Krzysztof
name: Finoguenov, Alexis
Publisher: name: arXiv
Year: 2014
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We present a new test of the validity of the Friedmann-Lemaitre-Robertson-Walker (FLRW) metric, based on comparing the distance from redshift 0 to $z_1$ and from $z_1$ to $z_2$ to the distance from $0$ to $z_2$. If the universe is described by the FLRW metric, the comparison provides a model-independent measurement of spatial curvature. The test relies on geometrical optics, it is independent of the matter content of the universe and the applicability of the Einstein equation on cosmological scales. We apply the test to observations, using the Union2.1 compilation of supernova distances and Sloan Lens ACS Survey galaxy strong lensing data. The FLRW metric is consistent with the data, and the spatial curvature parameter is constrained to be $-1.22
description: 6 pages, 1 figure. v2: fixed typos, clarified text. v3: fixed a mistake in data-fitting, improved analysis, clarified text, added a reference. Published version
Impact of Population III homogeneous stellar evolution on early cosmic reionisation
Creators: name: Sibony, Yves
name: Liu, Boyuan
name: Simmonds, Charlotte
name: Meynet, Georges
name: Bromm, Volker
Publisher: name: arXiv
Year: 2022
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Context: Population III (Pop III) stars may be fast rotating. An expected consequence of fast rotation is strong internal mixing that deeply affects their evolutionary tracks in the Hertzsprung-Russell diagram and hence their ionising power. aims: We investigate the impact on the ionising power of Pop III stars in an extreme case of internal mixing, the one leading to chemically homogeneous evolution (CHE). In that situation, during the main sequence phase, the star keeps the same chemical composition from its center to its surface. Homogeneous stars have larger effective temperatures and luminosities than stars evolving non-homogeneously and thus are stronger ionising sources. Methods: The stellar evolution models are based on $n=3$ polytropes with a time varying hydrogen mass fraction. The ionisation model employs the self-similar champagne flow solution from Shu et al. (2002), as well as numerical simulations for the stochastic treatment of star clusters over a grid of redshifts and halo masses. Results: We find that haloes containing chemically homogeneous stars have an escape fraction of ionising photons about twice that of haloes containing classical Pop III stars. By extrapolating the high-$z$ ionisation history powered by Pop III stars (at $z\gtrsim 15$) to the post-reionisation epoch, we derive the Thomson scattering optical depth $τ$, which is compared with the value measured by $\textit{Planck}$. We find that $τ$ is overproduced by $\sim1.5- 5σ$, when all Pop III stars evolve homogeneously. This indicates that CHE is unlikely to be realised in the majority of Pop III stars, although the present study cannot exclude that a fraction of them undergoes CHE. Conclusions: Fast rotation might have a significant impact on the ionising budget of Pop III stars, and thus on early cosmic reionisation.
description: Accepted for publication in A&A (12 August 2022); 13 pages, 9 figures
Additional file 1: of Neuronal impairment following chronic Toxoplasma gondii infection is aggravated by intestinal nematode challenge in an IFN-γ-dependent manner
Creators: name: French, Timothy
name: Düsedau, Henning
name: Steffen, Johannes
name: Aindrila Biswas
name: Norus Ahmed
name: Hartmann, Susanne
name: Schüler, Thomas
name: Schott, Björn
name: Dunay, Ildiko
Publisher: name: Figshare
Year: 2019
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: Figure S1. Reduced IL-4 and IL-13 gene expression in the spleen of co-infected mice. (A-B) qRT-PCR data for relative expression of mRNA in the spleen homogenate from non-infected (Non.Inf.), T. gondii-infected (Tg), T. gondii and H. polygyrus co-infected (Tg+Hp), and H. polygyrus-infected (Hp) mice. Relative mRNA levels were normalized to the mean of the non-infected control group (Non.Inf). Bars represent mean ± SEM. (PDF 33 kb)
Conditioning diffusion processes with respect to the local time at the origin
Creators: name: Mazzolo, Alain
name: Monthus, Cécile
Publisher: name: arXiv
Year: 2022
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Probability (math.PR)
subject: FOS: Physical sciences
subject: FOS: Mathematics

description: When the unconditioned process is a diffusion process $X(t)$ of drift $μ(x)$ and of diffusion coefficient $D=1/2$, the local time $A(t)= \int_{0}^{t} dτδ(X(τ)) $ at the origin $x=0$ is one of the most important time-additive observable. We construct various conditioned processes $[X^*(t),A^*(t)]$ involving the local time $A^*(T)$ at the time horizon $T$. When the horizon $T$ is finite, we consider the conditioning towards the final position $X^*(T)$ and towards the final local time $A^*(T)$, as well as the conditioning towards the final local time $A^*(T)$ alone without any condition on the final position $X^*(T)$. In the limit of the infinite time horizon $T \to +\infty$, we consider the conditioning towards the finite asymptotic local time $A_{\infty}^*<+\infty$, as well as the conditioning towards the intensive local time $a^* $ corresponding to the extensive behavior $A_T \simeq T a^*$, that can be compared with the appropriate 'canonical conditioning' based on the generating function of the local time in the regime of large deviations. This general construction is then applied to generate various constrained stochastic trajectories for three unconditioned diffusions with different recurrence/transience properties : (i) the simplest example of transient diffusion corresponds to the uniform strictly positive drift $μ(x)=μ>0$; (ii) the simplest example of diffusion converging towards an equilibrium is given by the drift $μ(x)=- μ\, {\rm sgn}( x)$ of parameter $μ>0$; (iii) the simplest example of recurrent diffusion that does not converge towards an equilibrium is the Brownian motion without drift $μ=0$.
description: 47 pages, 5 figures, added 2 tables
DRUG DESIGN AND DEVELOPMENT OF ALECTINIB AGAINST ALK PROTEIN DOMAIN FOR TREATMENT OF LUNG CANCER: AN IN-SILICO APPROACH
Creators: name: Bhuia, Md. Shimul
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 310101
subject: Analytical biochemistry

description: Alectinib (D) is an inhibitor of anaplastic lymphoma kinase (ALK) and approved by the USFDA for the treatment of non-small cell lung cancer (NSCLC). This study aims to develop & design new Alectinib derivatives which can be capable to inhibit more potently the activity of kinases other than ALK and better in pharmacokinetics than the parent drug in the treatment of NSCLC. The derivatives of Alectinib have been designed by using density functional theory (DFT) and the inhibitory performance of drugs was also explored by molecular docking study. We have investigated frontier molecular orbital features (HOMO, LUMO, gap, hardness, and softness), electrostatic potential, dipole moment and thermodynamic properties (electronic energy, enthalpy, Gibb’s free energy) of all the optimized drugs. The screening of the designed drugs (D-F, D-Cl, D-Br, D-CF3, D-OCH3, D-NH2) has been performed against ALK, RET, KDR, and KIT crystal structure of proteins. In our findings, the modified derivatives D-F and D-Cl revealed higher binding affinity -11.2 & -11.1 against ALK (PDB ID: 4TT7) respectively, where the parent drug showed binding affinity -10 against the same protein. The pharmacokinetic properties & toxicity of all drugs were predicted by preADMET, admetSAR@LMMD online database and MedChem designer. It assured that all the drugs are thermodynamically stable; some of them are more chemically reactive. In our computational investigation, we found that D-F & D-Cl are more potent inhibitors against ALK for the treatment of NSCLC than the parent drug. Finally, this study can be helpful for the design and development of new ALK inhibitors
Additional file 1 of Therapeutic options for patients with rare rheumatic diseases: a systematic review and meta-analysis
Creators: name: Bender, Tim T. A.
name: Leyens, Judith
name: Sellin, Julia
name: Kravchenko, Dmitrij
name: Conrad, Rupert
name: Mücke, Martin
name: Seidel, Matthias F.
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 1. Applied search strategy for each database.
Using Thermal Ratchet Mechanism to Achieve Net Motility in Magnetic Microswimmers
Creators: name: Patil, Gouri
name: Mandal, Pranay
name: Ghosh, Ambarish
Publisher: name: arXiv
Year: 2022
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Thermal ratchets can extract useful work from random fluctuations. This is common in the molecular scale, such as motor proteins, and has also been used to achieve directional transport in microfluidic devices. In this work, we use the ratchet principle to induce net motility in an externally powered magnetic colloid, which otherwise shows reciprocal (back and forth) motion. The experimental system is based on ferromagnetic micro helices driven by oscillating magnetic fields, where the reciprocal symmetry is broken through asymmetric actuation timescales. The swimmers show net motility with an enhanced diffusivity, in agreement with the numerical calculations. This new class of microscale, magnetically powered, active colloids can provide a promising experimental platform to simulate diverse active matter phenomena in the natural world.
Universal domain wall dynamics under electric field in Ta/CoFeB/MgO devices with perpendicular anisotropy
Creators: name: Lin, Weiwei
name: Vernier, Nicolas
name: Agnus, Guillaume
name: Garcia, Karin
name: Ocker, Berthold
name: Zhao, Weisheng
name: Fullerton, Eric E.
name: Ravelosona, Dafiné
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: Electric field effects in ferromagnetic/oxide dielectric structures provide a new route to control domain wall (DW) dynamics with low power dissipation. However, electric field effects on DW velocities have only been observed so far in the creep regime where DW velocities are low due to strong interactions with pinning sites. Here, we show gate voltage modulation of DW velocities ranging from the creep to the flow regime in Ta/Co40Fe40B20/MgO/TiO2 structures with perpendicular magnetic anisotropy. We demonstrate a universal description of the role of applied electric fields in the various pinning dependent regimes by taking into account an effective magnetic field being linear with the electric field. In addition, the electric field effect is found to change sign in the Walker regime. Our work opens new opportunities for the study and optimization of electric field effect at ferromagnetic metal/insulator interfaces.
description: 21 pages, 6 figures