cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Investigation of pyrrolizidine alkaloids including their respective N-oxides in selected food products available in Hong Kong by liquid chromatography electrospray ionisation mass spectrometry
Creators: name: Chung, Stephen W. C.
name: Lam, Aaron C. H.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy
subject: 60506 Virology

description: This study determined the levels of pyrrolizidine alkaloids (PAs), including their respective N-oxides, in foodstuffs available in Hong Kong by liquid chromatography-electrospray ionisation tandem mass spectrometry. A total of 234 samples (48 food items) were collected randomly from a local market and analysed. About 50% of samples were found to contain detectable amount of PAs. Amongst the 48 food items, PAs were not detected in 11 food items, including barley flour, beef, cattle liver, pork, pig liver, chicken meat, chicken liver, milk, non-fermented tea, Melissa tea and linden tea. For those found to contain detectable PAs, the summed PA content ranged up to 11,000 µg kg−1. The highest sum of PA content among the 37 food items calculated with lower bound was cumin seed, then followed by oregano, tarragon and herbs de Provence with ranges of 2.5–11,000, 1.5–5100, 8.0–3300 and 18–1300 µg kg−1 respectively. Among the samples, the highest sum of PA content was detected in a cumin seed sample (11,000 µg kg−1), followed by an oregano (5100 µg kg−1), a tarragon (3300 µg kg−1) and a herbs de Provence (1300 µg kg−1). In general, the results of this study agreed well with other published results in peer-reviewed journals, except that the total PAs in honey and specific tea infusion in this study were comparatively lower.
Syntheses of Polyalkylated Imidazoles
Creators: name: Sigvart Evjen
name: Fiksdahl, Anne
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Marine Biology

description: We have developed improved general simple methods for large scale preparation of polyalkylated imidazoles by improved multi-component synthesis from commercially available starting materials. A large range of NH- and N-alkyl-polyalkylimidazoles (40 in total, including novel compounds) has been synthesised.
Efficient Synthesis of the Related Substances of Cinacalcet Hydrochloride via Heck Coupling
Creators: name: Lei, Fan
name: Qu, Boyi
name: Li, Xiaolong
name: Guo, Li
name: Guan, Mei
name: Hai, Li
name: Jin, Hui
name: Wu, Yong
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Biological Sciences
Chemistry
Earth and Environmental Sciences
Biotechnology
Pharmacology
Molecular Biology
Physics
Engineering
Biochemistry
Biophysics

description: Efficient synthetic methods to process related substances of Cinacalcet hydrochloride 1, generated during the preparation, were described. The compounds were identified as [1-(7, 8-dihydro-naphthalen-1-yl)-ethyl]-[3-(3-trifluoromethyl-phenyl)-propyl]-amine hydrochloride 2, [1-(5, 6, 7, 8-tetrahydro-naphthalen-1-yl)-ethyl]-[3-(3-trifluoromethyl-phenyl)- propyl]-amine hydrochloride 3 and [1-(naphthalen-2-yl)-ethyl]-[3-(3-trifluoromethyl-phenyl)- propyl]-amine hydrochloride 4. All were prepared from commercially available materials in several linear steps and characterized by their respective spectral data.
O Carnaval na ilha Terceira
Creators: name: Duarte, Luiz Fagundes
Publisher: name: Comunicação & Cultura
Year: 2010

description: O Carnaval na ilha Terceira tem características que o distinguem no contexto açoriano, nacional e internacional: os folguedos tradicionalmente atribuídos a este período do ano têm vindo a ser, progressivamente, substituídos por representações teatrais combinadas com música e dança, que envolvem quase toda a população da ilha. Estas representações são designadas como «danças», que na sua vertente satírica são denominadas «bailhinhos», e não se inscrevem na categoria de folclore. Os textos, as músicas e as coreografias são da autoria dos participantes, sendo os textos, sempre originais e motivados por acontecimentos da actualidade, compostos em versos rimados de redondilha maior, frequentemente encomendados a poetas populares. A origem deste fenómeno da cultura popular remonta provavelmente ao século xvi, e radica no teatro ibérico representado nas naus que cruzavam o Atlântico ao longo dos séculos xvi-xviii, podendo ser nele identificados alguns traços que o ligam ao circuito transatlântico da escravatura e da produção do açúcar, e a algumas tradições coreográficas e dramatúrgicas do Nordeste brasileiro.
description: Comunicação & Cultura, n. 10 (2010): A festa
O mundo dos mortos no quotidiano dos vivos: celebrar a morte nas Misericórdias portuguesas da época moderna
Creators: name: Araújo, Maria Marta Lobo De
Publisher: name: Comunicação & Cultura
Year: 2010

description: O nosso trabalho analisa as celebrações da morte nas Misericórdias portuguesas da idade moderna, destacando o papel ocupado pelos mortos no quotidiano dos vivos. Estudamos as práticas mortuárias e os mecanismos desencadeados por estas instituições para alcançar a salvação, demonstrando o peso da morte no reino dos vivos.
description: Comunicação & Cultura, n. 10 (2010): A festa
A emergência da rádio e a vulgarização do entretenimento no lar
Creators: name: Ribeiro, Nelson
Publisher: name: Comunicação & Cultura
Year: 2010

description: O artigo analisa as alterações introduzidas na vida quotidiana pela emergência da rádio: o primeiro meio de comunicação a entrar no interior dos lares. Coincidindo com uma necessidade de comodização do lazer, nos anos 20 e 30 do século passado, a radiodifusão foi responsável por mudanças nas formas de organização familiar e social, levando o entretenimento – até então confinado a espaços públicos – até ao seio da vida familiar. Além de conferir dimensão nacional a acontecimentos locais, na primeira metade do século xx, as estações de rádio deram igualmente um importante contributo para a promoção da identidade nacional em diversos países. Tal ficou a dever-se, sobretudo, à capacidade de agregar um número elevado de ouvintes, o que foi possível com a implementação de estratégias de programação baseadas na transmissão de conteúdos de índole popular, contribuindo decisivamente para a afirmação da cultura de massas.
description: Comunicação & Cultura, n. 10 (2010): A festa
Céramique
Amphore à col pseudo-chaldinienne
amphore à col attique
Creators: name: SAM
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2016

description: amphore à col
description: Provenance: Caeré
description: date: VIe, 3e quart
A new naphthalene glycoside from the sponge-derived fungus Arthrinium sp. ZSDS1-F3
Creators: name: Wang, Jun-Feng
name: Xu, Fu-Quan
name: Wang, Zhen
name: Lu, Xin
name: Wan, Jun-Ting
name: Yang, Bin
name: Zhou, Xue-Feng
name: Zhang, Tian-Yu
name: Tu, Zheng-Chao
name: Liu, Yonghong
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorised

description: One new naphthalene derivative, 1,8-dihydroxynaphthol-1-O-α-l-rhamnopyranoside (1), together with one known α-dibenzopyrone, alternariol (2), and five xanthones (3–7) were isolated from the sponge-derived fungus Arthrinium sp. ZSDS1-F3. All the isolated compounds (1–7) were established by comprehensive analysis of the spectral data, especially 1D and 2D NMR (HMQC and HMBC) spectra. In the primary bioassays, compound 3 exhibited moderate COX-2 inhibition, with IC50 values of 12.2 μM.
Optimization of the Performance of Micro Hydro-Turbines for Electricity Generation
Creators: name: Yassen, Saeed Rajab
Publisher: name: University of Hertfordshire
Year: 2014
Subjects: turbomachine
water turbine
micro hydro-turbines
electricity generation

description: Rural electrification has long been the most important topic on the development agenda of many countries. The needs for power supplies to rural areas increased significantly in the past decades. Extending electricity grids to rural areas is of a very high initial cost and is not viable economically. Micro hydroelectric power plants provide a good economical solution, which is also environmentally very friendly. The current study concentrates on selecting and optimizing a suitable cross-flow micro-turbine to be used in micro hydroelectric power plants. Cross-flow turbines are in general of simple structure, low cost, easy to fabricate and of modest efficiency. The main purpose of the present work is to optimize the performance of a selected turbine by establishing the optimal turbine’s design parameters. A complete analysis of the internal flow, which is of turbulent, two-phase and three dimensional in nature, was undertaken by simulating it using various CFD simulation codes. This study reports on the flow simulation using ANSYS CFX with a two-phase flow model, water-air free surface model and shear stress transport (SST) turbulence model. Prediction velocity and pressure fields of inside the turbine are, subsequently, used to characterize the turbine performance for different geometric parameters including the number of runner blades, the angle of attack, the ratio of inner to outer diameter, the nozzle profile, the blade profile, the nozzle throat width, the nozzle to runner blades width and the runner blades width to outer runner diameter. The results revealed the highly complex nature of the flow and provided a very good insight to the flow structure and performance optimization parameters.
Synthesis, Molecular Modeling of N-acyl Benzoazetinones and their Docking Simulation on Fungal Modeled Target
Creators: name: Inul Ansary
name: Arijit Das
name: Parth Sarthi Sen Gupta
name: Bandyopadhyay, Amal Kumar
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Computational Biology

description: A series of stable N-acyl benzoazetinones have been synthesized in moderate to good yields (58-85%) from easily available substrates such as 2-(N-acyl) amino benzoic acids via intramolecular amidation under mild conditions. These geometry-optimized benzoazetinones were docked in the model target of P450, class CYP53A15, a benzoate 4-monooxygenase abundantly found in the genome of ascomycetes and basidiomycetes classes of pathogenic fungi. Low per residue RMSD of modeled structure of the enzyme indicated similar topology as template (4D6Z.pdb). Observed score judges site-specific docking, and the interaction of quantum mechanically optimized benzoazetinone derivatives with the target enzyme. These results suggest that 3i is the best antifungal agent. The specific hydrophobic substituent in the benzoazetinones contributed to the stability of ligand-target complex. Overall, the study provided insight into the specificity of the site-specific interactions, thereby, facilitating the possibility of development of broad-spectrum antifungal agents against opportunistic and infectious fungi.
MOESM10 of Detecting significant genotype–phenotype association rules in bipolar disorder: market research meets complex genetics
Creators: name: Breuer, René
name: Mattheisen, Manuel
name: Frank, Josef
name: Krumm, Bertram
name: Treutlein, Jens
name: Kassem, Layla
name: Strohmaier, Jana
name: Herms, Stefan
name: Mühleisen, Thomas
name: Degenhardt, Franziska
name: Cichon, Sven
name: Nöthen, Markus
name: Karypis, George
name: Kelsoe, John
name: Greenwood, Tiffany
name: Nievergelt, Caroline
name: Shilling, Paul
name: Shekhtman, Tatyana
name: Edenberg, Howard
name: Craig, David
name: Szelinger, Szabolcs
name: Nurnberger, John
name: Gershon, Elliot
name: Alliey-Rodriguez, Ney
name: Zandi, Peter
name: Goes, Fernando
name: Schork, Nicholas
name: Smith, Erin
name: Koller, Daniel
name: Zhang, Peng
name: Badner, Judith
name: Berrettini, Wade
name: Bloss, Cinnamon
name: Byerley, William
name: Coryell, William
name: Foroud, Tatiana
name: Guo, Yirin
name: Hipolito, Maria
name: Keating, Brendan
name: Lawson, William
name: Liu, Chunyu
name: Mahon, Pamela
name: McInnis, Melvin
name: Murray, Sarah
name: Nwulia, Evaristus
name: Potash, James
name: Rice, John
name: Scheftner, William
name: Zöllner, Sebastian
name: McMahon, Francis
name: Rietschel, Marcella
name: Schulze, Thomas
Publisher: name: figshare
Year: 2018
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: Additional file 10: Table S5. Association results of the case-control analyses for the top 5 replication patterns.
Cardenolides from the bark of Calotropis gigantea
Creators: name: Van Khang, Pham
name: Zhang, Zhong-Guo
name: Meng, Yu-Hui
name: Guo, De-An
name: Liu, Xuan
name: Hu, Li-Hong
name: Ma, Lei
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorised

description: Three new cardenolides (1–3) were isolated from the 90% ethanolic extract of the bark of a wild-type Calotropis gigantea. Their structures were determined by using NMR spectra and LC-MS analysis. Their inhibitory activities were evaluated against non-small cell lung carcinoma (A549) and human cervix epithelial adenocarcinoma (HeLa) cell lines. Compounds 1 and 3 exhibited strong inhibitory effect on two cancer cell lines.
Chemical composition of rosehips from different Rosa species: an alternative source of antioxidants for the food industry
Creators: name: Jiménez, Sandra
name: Jiménez-Moreno, Nerea
name: Luquin, Asunción
name: Laguna, Mariano
name: Rodríguez-Yoldi, María Jesús
name: Ancín-Azpilicueta, Carmen
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: It is important to explore new sources of natural additives because the demand for these compounds by consumers is increasing. These products also provide health benefits and help in food preservation. An unexplored source of nutrients and antioxidant compounds is rosehip, the fleshy fruit of roses. This work compares the antioxidant compound (vitamin C, neutral phenols and acidic phenols) content of four Rosa species rosehips: R. pouzinii, R. corymbifera, R. glauca and R. canina from different geographical zones. Results show quantitative variability in ascorbic acids and neutral phenols content, and quantitative and qualitative differences in acidic phenol content, depending on species. Vitamin C concentration was highly variable depending on species, R. canina being the one with the highest concentration and R. pouzinii the one with the lowest content. Variability was found in total neutral polyphenols concentration and a correlation between freshness of the rosehips and concentration of neutral polyphenols was also found. Significant differences were found in the acidic phenols content among the studied species. Generally antioxidant activity was higher in the vitamin C fraction.
A Single Case Design Study Evaluating the Impact of a Values Based Positive Self Affirmations Intervention on Eating Disorder Symptons in Women with Bulimia Nervosa
Creators: name: Cullen, Ella
Publisher: name: University of Hertfordshire
Year: 2014
Subjects: eating disorders
bulimia nervosa
self-affirmations
personal values
intervention

description: Numerous studies have reported psychological benefits associated with the practice of values-based selfaffirmation. However, there is little evidence regarding their clinical applicability. Many of the purported benefits of values-based self-affirmation are highly relevant to people with bulimia nervosa (BN). This study used a multiple case study design in order to investigate the effectiveness, underlying mechanisms and acceptability of a brief (three week) intervention focussing on the development and practice of values-based self-affirmations with people who have BN. Two participants were recruited from an Eating Disorders (ED) Service waiting list. They completed questionnaires measuring cognitions associated with ED, attitude towards change, self-esteem, self-compassion, body image acceptance, psychological flexibility, cognitive defusion, and SELF repertory grids over four time points. Following appointments qualitative data was collected, and on completion of the intervention participants were interviewed, regarding their experiences. Pre and post intervention behavioural measures of BN were also collected. The use of a personal values-based self-affirmation intervention was associated with reductions in behaviours associated with BN, enhanced attitude towards change and reduced discrepancy between self and ideal self. There was little convincing evidence that the intervention was associated with a reduction in cognitions associated with ED. A very small degree of change in a positive direction was observed in relation to self-esteem, self-compassion, body image acceptance, psychological flexibility and cognitive fusion. However, scores did not reflect Reliable Change in these processes. Overall, results appeared to be slightly better explained by theory underpinning Personal Construct Psychotherapy rather than Acceptance and Commitment Therapy. However, neither theoretical explanation fully accounted for the data. Participants generally found the intervention to be acceptable. The results add novel findings to the literature regarding the use of values-based self-affirmation within the treatment of BN. They suggest that a brief values-based self-affirmation intervention might be a useful adjunct to evidence based treatment of BN. However, the case study design that is utilised in this study limits the degree to which these results may be generalised and future research should explore this further.
Growth arrest-specific protein 6 (Gas6) as a noninvasive biomarker for early detection of diabetic nephropathy
Creators: name: Wenni Li
name: Junlin Wang
name: Ge, Lina
name: Jiehui Shan
name: Chunbing Zhang
name: Jianping Liu
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Cancer
subject: 60506 Virology

description: Background: To investigate the diagnostic level of cystatin C and growth arrest-specific gene 6 (Gas6) levels in elderly type 2 diabetic patients with different degrees of diabetic nephropathy (DN). Methods: Four hundred and eighty-two old people, including 130 healthy controls, 130 normoalbuminuric diabetic patients, 122 with microalbuminuria, and 100 with macroalbuminuria, were recruited. Plasma Gas6 and serum cystatin C levels were measured. Results: Plasma Gas6 concentration was significantly lower in diabetic patients with microalbuminuria or macroalbuminuria, as compared with diabetic subjects with normoalbuminuria; while cystatin C was significantly higher. Gas6 was inversely correlated with BMI, WHR, and HbA1c, while cystatin C was inversely correlated with urea nitrogen and creatinine. Multivariate logistic regression analysis showed that, after adjusted for established diabetes risk factors, higher plasma Gas6 was significantly associated with a decreased risk of DN, while higher serum cystatin C was significantly associated with an increased risk. Receiver operating characteristic curve analysis showed that Gas6 was better than cystatin C as a biomarker for early diagnosis and detection of DN, with a cutoff value of 9.435 ng/mL (86.1% sensitivity and 84.6% specificity). Conclusion: Compared to cystatin C, Gas6 may be potentially a better noninvasive diagnostic biomarker for early detection of DN.
A family of metallocyclodextrins: synthesis, absorption and luminescence characteristic studies based on host–guest recognition
Creators: name: Qi, Yantao
name: Wang, Xiuhua
name: Chen, Hong
name: Tang, Jie
name: Yang, Fan
name: He, Pingang
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Cancer
Chemistry
Earth and Environmental Sciences
Neuroscience
Cell Biology
Engineering
Biochemistry
Biophysics

description: A family of metallocyclodextrins bearing one, two, three or six β-cyclodextrin binding sites on their ligands have been synthesised, and their structures were confirmed by 1H NMR, 13C NMR, MALDI-TOF MS, UV–vis spectroscopy and elemental analysis. Comparative investigation of the luminescent properties of these metallocyclodextrins found that 6CD-Ru showed the strongest fluorescence intensity. The fluorescence quantum yield results show that 6CD-Ru exhibits the highest emission efficiency, as we expected. To gain insight into the binding properties of the most promising metallocyclodextrin 6CD-Ru, two guest compounds 4-dimethylaminoazobenzene-4′-carboxylic acid (Dab) and methylene blue (MB) were used as analytes. 6CD-Ru exhibited remarkable emission quenching compared with the reference compound CD-Ru. Furthermore, calculated binding constants demonstrated that 6CD-Ru has enhanced binding capacity due to the presence of multiple β-cyclodextrin binding sites. These prominent characteristics of 6CD-Ru suggest that it may be used to detect the two guests Dab and MB, and their analogues, with greater sensitivity, and the relevant research with these metallocyclodextrins is in progress in our group.
Determination of mycotoxins in biscuits, dried fruits and fruit jams: an assessment of human exposure
Creators: name: Škrbić, Biljana
name: Antić, Igor
name: Cvejanov, Jelena
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy

description: A reliable, fast and simple method using UHPLC-MS/MS was developed for the determination of aflatoxins B1 (AFB1), G1 (AFG1), B2 (AFB2) and G2 (AFG2), ochratoxin A (OTA), deoxynivalenol (DON), zearalenone (ZEA), HT-2 toxin and T-2 toxin in crude extracts of biscuits with fruit filling, cookies, dried fruits and fruit jams. The method was successfully demonstrated on 39 samples of biscuits with fruit filling, 34 cookies, 14 dried fruits and 10 fruit jams. The mycotoxins detected in biscuits samples were ZEA, OTA, T-2 and AFB1 with an average concentrations of positive samples of 2.64, 4.10, 8.13 and 1.32 µg kg−1, respectively; while the mycotoxins detected in jam samples were AFB1, OTA, T-2 and AFB2 with an average concentrations of positive samples of 2.00, 17.7, 4.37 and 1.15 µg kg−1, respectively. The results showed that the majority of samples were in compliance with relevant regulations. However in eight samples of biscuits and three samples of fig jam the contents of OTA were higher than the existing OTA limits. The combined dietary exposure of selected mycotoxins was estimated for the first time for children, adolescents and adults. The estimated combined dietary exposures were all lower than the proposed value assumed to predict a possible risk scenario.
Endothelial TRPV4 Dysfunction in a Streptozotocin-Diabetic Rat Model
Creators: name: Shamsaldeen, Yousif
Publisher: name: UH Research Archive
Year: 2017
Subjects: Diabetes mellitus
Transient receptor potential channels
TRPV4
TRPM8
Endothelial nitric oxide synthase
Inducible nitric oxide synthase
Nitric oxide
Caveolae
Methylglyoxal
Insulin
Diabetes endothelial dysfunction
Endothelial cells
Vascular smooth muscle cells
L-arginine
Akt
P38
Vasodilation

description: Diabetes mellitus is a complex disease characterised by chronic hyperglycaemia due to compromised insulin synthesis and secretion, or decreased tissue sensitivity to insulin, if not all three conditions. Endothelial dysfunction is a common complication in diabetes in which endothelium-dependent vasodilation is impaired. The aim of this study was to examine the involvement of TRPV4 in diabetes endothelial dysfunction. Male Charles River Wistar rats (350–450 g) were injected with 65mg/kg streptozotocin (STZ) intraperitoneally. STZ-injected rats were compared with naïve rats (not injected with STZ) or control rats (injected with 10ml/kg of 20mM citrate buffer, pH 4.0–4.5), if not both. Rats with blood glucose concentrations greater than 16mmol/L were considered to be diabetic. As the results revealed, STZ-diabetic rats showed significant endothelial dysfunction characterised by impaired muscarinic-induced vasodilation, as well as significant impairment in TRPV4-induced vasodilation in aortic rings and mesenteric arteries. Furthermore, STZ-diabetic primary aortic endothelial cells (ECs) showed a significant reduction in TRPV4-induced intracellular calcium ([Ca2+]i) elevation. TRPV4, endothelial nitric oxide synthase (eNOS), and caveolin-1 (CAV-1) were also significantly downregulated in STZ-diabetic primary aortic ECs and were later significantly restored by in vitro insulin treatment. Methylglyoxal (MGO) was significantly elevated in STZ-diabetic rat serum, and nondiabetic aortic rings incubated with MGO (100μM) for 12 hours showed significant endothelial dysfunction. Moreover, nondiabetic primary aortic ECs treated with MGO (100μM) for 5 days showed significant TRPV4 downregulation and significant suppression of 4-α-PDD-induced [Ca2+]i elevation, which was later restored by L-arginine (100μM) co-incubation. Incubating nondiabetic aortic rings with MGO (100μM) for 2 hours induced a spontaneous loss of noradrenaline-induced contractility persistence. Moreover, MGO induced significant [Ca2+]i elevation in Chinese hamster ovary cells expressing rat TRPM8 channels (rTRPM8), which was significantly inhibited by AMTB (1–5μM). Taken together, TRPV4, CAV-1, and eNOS can form a functional complex that is downregulated in STZ-diabetic aortic ECs and restored by insulin treatment. MGO elevation might furthermore contribute to diabetes endothelial dysfunction and TRPV4 downregulation. By contrast, MGO induced the loss of contractility persistence, possibly due to MGO’s acting as a TRPM8 agonist.
MOESM1 of Detecting significant genotype–phenotype association rules in bipolar disorder: market research meets complex genetics
Creators: name: Breuer, René
name: Mattheisen, Manuel
name: Frank, Josef
name: Krumm, Bertram
name: Treutlein, Jens
name: Kassem, Layla
name: Strohmaier, Jana
name: Herms, Stefan
name: Mühleisen, Thomas
name: Degenhardt, Franziska
name: Cichon, Sven
name: Nöthen, Markus
name: Karypis, George
name: Kelsoe, John
name: Greenwood, Tiffany
name: Nievergelt, Caroline
name: Shilling, Paul
name: Shekhtman, Tatyana
name: Edenberg, Howard
name: Craig, David
name: Szelinger, Szabolcs
name: Nurnberger, John
name: Gershon, Elliot
name: Alliey-Rodriguez, Ney
name: Zandi, Peter
name: Goes, Fernando
name: Schork, Nicholas
name: Smith, Erin
name: Koller, Daniel
name: Zhang, Peng
name: Badner, Judith
name: Berrettini, Wade
name: Bloss, Cinnamon
name: Byerley, William
name: Coryell, William
name: Foroud, Tatiana
name: Guo, Yirin
name: Hipolito, Maria
name: Keating, Brendan
name: Lawson, William
name: Liu, Chunyu
name: Mahon, Pamela
name: McInnis, Melvin
name: Murray, Sarah
name: Nwulia, Evaristus
name: Potash, James
name: Rice, John
name: Scheftner, William
name: Zöllner, Sebastian
name: McMahon, Francis
name: Rietschel, Marcella
name: Schulze, Thomas
Publisher: name: figshare
Year: 2018
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mental Health

description: Additional file 1: Table S1. Descriptive data for patients with bipolar disorder and controls.
Entrevista a Gilles Lipovetsky
Creators: name: Ganito, Carla
name: Maurício, Ana Fabíola
Publisher: name: Comunicação & Cultura
Year: 2010

description: Gilles Lipovetsky, filósofo e professor da Universidade de Grenoble, é o autor de A Era do Vazio [1983] e A Terceira Mulher [1997], entre várias outras obras. A presente entrevista decorreu em Lisboa, durante a conferência «A Cultura Planetária na Era Hipermoderna», realizada na Universidade Católica Portuguesa. Este encontro deu-se por ocasião do lançamento do seu novo livro O Ecrã Global, em co-autoria com Jean Serroy, em Março de 2010.
description: Comunicação & Cultura, n. 9 (2010): Pós-género
Anti-depressive activities and biotransformation of timosaponin B-III and its derivatives
Creators: name: Jiang, WeiXin
name: Guo, Jing
name: Xue, Rui
name: Zhu, KaiCheng
name: Li, ZhiXiong
name: Chen, MingCang
name: Huang, ChengGang
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorised

description: Timosaponin B-III (TB-III) is a steroidal saponin isolated from the rhizome of Anemarrhenae asphodeloides (Liliaceae). The biotransformation of TB-III by β-glucosidase was investigated. Three biotransformation products were isolated and their structures were identified as timosaponin B-III-a (M1), (20R,25S)-5β-spirostane-3β-ol-3-O-β-d-glucopyranosyl-(1 → 2)-β-d-galacopyanoside (M2) and timosaponin AIII (M3). Then the four compounds were evaluated for their anti-depressive activity in mice by the open field test, tail suspension test and forced swimming test. As a result, TB-III, M1 and M3 exhibited modest anti-depressive activity. Structure–activity relationships were investigated and the preliminary conclusions are summarised as follows: the glycosyl at C-3 and C-26 can increase the activity, the double bond between C-20 and C-22 might be important for the anti-depressive activity, the R-configuration at C-22 and S-configuration at C-20 are necessary for its anti-depressive activity.
Entrevista a Gaye Tuchman
Creators: name: Rosa, Gonçalo Pereira
Publisher: name: Comunicação & Cultura
Year: 2010

description: A socióloga Gaye Tuchman esteve em Portugal a 20 de Outubro de 2009, a convite da Fundação Luso-Americana para o Desenvolvimento (FLAD), onde deu uma palestra sobre as «Mudanças nas Universidades Americanas». Esta investigadora da Universidade de Connecticut, com trabalho reconhecido no campo da sociologia do jornalismo e da sociologia do género, abordou o seu legado sobre a evolução do conhecimento nestas áreas e estabeleceu balizas para a investigação futura.
description: Comunicação & Cultura, n. 9 (2010): Pós-género
Festa e identidade
Creators: name: Teixeira, Joaquim De Sousa
Publisher: name: Comunicação & Cultura
Year: 2010

description: A festa é, por definição, um evento colectivo. Depois de uma breve crítica a algumas teorias, conclui-se pela importância de dois elementos nucleares: o formal (o objecto da festa) e o material (os ingredientes). Toda a festa é cerimónia e festividade. O tempo da festa, essencial na sua caracterização, é uma ruptura com o tempo anódino, visando dar mais sentido à existência de quem celebra. Apesar do fim de certas festas na Europa moderna, do avanço do utilitarismo racionalista e das revoluções, defende-se o carácter antropologicamente necessário da celebração festiva e o seu papel insuprível no processo de identificação dos indivíduos, dos grupos sociais, das nações. Contra a tentativa pós-moderna e pagã de fazer da festa um acontecimento de indiferenciação ou dissolução na Natureza, reivindica-se, no seio da própria exultação festiva, a «diferenciação da consciência».
description: Comunicação & Cultura, n. 10 (2010): A festa
Festas régias e comunicação política no Portugal moderno (1521-1572)
Creators: name: Buesco, Ana Isabel
Publisher: name: Comunicação & Cultura
Year: 2010

description: Deixando de lado outras materializações e irrupções da festa e do lúdico igualmente significantes, como é todo o universo da festa no âmbito da cultura dita «popular» e da festa religiosa e litúrgica, objecto de numerosíssimos estudos quer para a época medieval quer para a moderna, o objecto deste trabalho será uma reflexão sobre as festas da realeza, aqui tomadas no sentido mais amplo de celebrações cerimoniais, no Portugal quinhentista. Procurar-se-á evidenciar como todas elas, tão diferentes na sua essência e finalidade, eram parte integrante de um sistema de comunicação política, comum à generalidade das monarquias de Antigo Regime.
description: Comunicação & Cultura, n. 10 (2010): A festa
Integrating induced seismicity with rock mechanics: a conceptual model for the 2011 Preese Hall fracture development and induced seismicity
Creators: name: R. Westaway
Publisher: name: Geological Society of London
Year: 2017
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: Background information on the stratigraphy, structural geology, rockmechanical properties of the study region and its state of stress, as well as theory for fluid injection, hydraulic fracturing and Coulomb failure analysis
Synthesis, crystal structures, and biological activity of oxovanadium(V) complexes with similar tridentate hydrazone ligands
Creators: name: Sheng, Gui-Hua
name: Han, Xiao
name: You, Zhonglu
name: Li, Hai-Hua
name: Zhu, Hai-Liang
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorised

description: Two new oxovanadium(V) complexes, [VOL1(OEt)(EtOH)] (1) and [VOL2(OMe)(MeOH)] (2), were prepared by reaction of [VO(acac)2] (where acac = acetylacetonate) with N′-(3-bromo-2-hydroxybenzylidene)-4-methylbenzohydrazide (H2L1) in ethanol and N′-(3-bromo-2-hydroxybenzylidene)-4-methoxybenzohydrazide (H2L2) in methanol, respectively. Crystal and molecular structures of the complexes were determined by elemental analysis, infrared spectra, and single-crystal X-ray diffraction. The V ions have octahedral coordination. Thermal stability and the inhibition of urease of the complexes were studied.
Supplementary Material for: Low Back Pain in Pregnancy: Investigations, Management, and Role of Neuraxial Analgesia and Anaesthesia: A Systematic Review
Creators: name: Sehmbi, H.
name: D'Souza, R.
name: Bhatia, A.
Publisher: name: Karger Publishers
Year: 2017
Subjects: Medicine

description: Background: Low back pain (LBP) is commonly experienced during pregnancy and is often poorly managed. There is much ambiguity in diagnostic work-up, appropriate management and decision-making regarding the use of neuraxial analgesia and anaesthesia during labour and delivery in these patients. This systematic review summarises the evidence regarding investigations, management strategies and considerations around performing neuraxial blocks for pregnant women with LBP. Methods: We searched 3 databases and reviewed literature concerning LBP in pregnancy with regards to diagnostic modalities, management strategies and use of neuraxial techniques for facilitating labour and delivery. Results: In all, we included 78 studies in this review, with 32 studies concerning diagnostic investigations, 56 studies involving management strategies, and 4 studies regarding the use of neuraxial techniques for labour and delivery. Summary: MRI is the safest investigative modality for LBP in pregnancy. Antenatal educational programmes, exercise and steroid injections into the epidural space or sacroiliac joints may help with pain management. Worsening neurological deficits, vertebral fractures and tumours may need surgical management. There is limited evidence on challenges of performing neuraxial blocks in the peripartum period for analgesia and anaesthesia, but there is a potential for increased risk of neurological complications in parturients with pre-existing neurological deficits.
Synthesis, crystal structures and biological activity of oxovanadium(V) complexes with similar tridentate hydrazone ligands
Creators: name: Sheng, Gui-Hua
name: Han, Xiao
name: You, Zhonglu
name: Li, Hai-Hua
name: Zhu, Hai-Liang
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorised

description: Two new oxovanadium(V) complexes, [VOL1(OEt)(EtOH)] (1) and [VOL2(OMe)(MeOH)] (2), were prepared by reaction of [VO(acac)2] (where acac = acetylacetonate) with N’-(3-bromo-2-hydroxybenzylidene)-4-methylbenzohydrazide (H2L1) in ethanol and N’-(3-bromo-2-hydroxybenzylidene)-4-methoxybenzohydrazide (H2L2) in methanol, respectively. Crystal and molecular structures of the complexes were determined by elemental analysis, infrared spectra and single crystal X-ray diffraction. The V ions have octahedral coordination. Thermal stability and the inhibition of urease of the complexes were studied.
Diffusion Data.pdf
Creators: name: Thomas, Astrid
name: Hanel, Birgitte
name: Marott, Jacob
name: Buchvald, Frederik
name: Mortensen, Jann
name: Nielsen, Kim Gjerum
Publisher: name: figshare
Year: 2017
Subjects: subject: 111499 Paediatrics and Reproductive Medicine not elsewhere classified
subject: FOS: Clinical medicine
subject: Medicine

description: Data for the publication: Thomas A, Hanel B, Marott JL, Buchvald F, Mortensen J, Nielsen KG (2014) The Single-Breath Diffusing Capacity of CO and NO in Healthy Children of European Descent. PLoS ONE 9(12): e113177. https://doi.org/10.1371/journal.pone.0113177
Editorial and front matter: Colloquy, Issue 19, June 2010
Creators: name: Colloquy
Publisher: name: Monash University
Year: 2017
Subjects: subject: 200599 Literary Studies not elsewhere classified
subject: FOS: Languages and literature

description: Issue 19 of Colloquy: text, theory, critique is a general issue. A wide range of topics is traversed: from translation to "coming out," the predicaments of late capitalism to the construction of memory, with references that range through Benjamin, Derrida, Sebald and Peirce. The issue is completed by a number of book reviews. The editors wish to thank the many referees who made this issue possible.
This issue sees the debut of three new Editors-in-Chief: David Blencowe, Timothy Chandler and Catherine Ryan. Accordingly, the editorial team wishes to acknowledge the contribution made to Colloquy by outgoing Editor-in-Chief, Geoff Berry. Geoff has given much time, passion and enthusiasm to Colloquy over the last few years, and for this we thank him.
MOESM2 of Detecting significant genotype–phenotype association rules in bipolar disorder: market research meets complex genetics
Creators: name: Breuer, René
name: Mattheisen, Manuel
name: Frank, Josef
name: Krumm, Bertram
name: Treutlein, Jens
name: Kassem, Layla
name: Strohmaier, Jana
name: Herms, Stefan
name: Mühleisen, Thomas
name: Degenhardt, Franziska
name: Cichon, Sven
name: Nöthen, Markus
name: Karypis, George
name: Kelsoe, John
name: Greenwood, Tiffany
name: Nievergelt, Caroline
name: Shilling, Paul
name: Shekhtman, Tatyana
name: Edenberg, Howard
name: Craig, David
name: Szelinger, Szabolcs
name: Nurnberger, John
name: Gershon, Elliot
name: Alliey-Rodriguez, Ney
name: Zandi, Peter
name: Goes, Fernando
name: Schork, Nicholas
name: Smith, Erin
name: Koller, Daniel
name: Zhang, Peng
name: Badner, Judith
name: Berrettini, Wade
name: Bloss, Cinnamon
name: Byerley, William
name: Coryell, William
name: Foroud, Tatiana
name: Guo, Yirin
name: Hipolito, Maria
name: Keating, Brendan
name: Lawson, William
name: Liu, Chunyu
name: Mahon, Pamela
name: McInnis, Melvin
name: Murray, Sarah
name: Nwulia, Evaristus
name: Potash, James
name: Rice, John
name: Scheftner, William
name: Zöllner, Sebastian
name: McMahon, Francis
name: Rietschel, Marcella
name: Schulze, Thomas
Publisher: name: figshare
Year: 2018
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 2: Table S2. Details on the 23 phenotypic traits included into the study.
Negative: On the Translation of Jacques Derrida, Mal d’Archive
Creators: name: Barker, Daniel James
Publisher: name: Monash University
Year: 2017
Subjects: subject: 200599 Literary Studies not elsewhere classified
subject: FOS: Languages and literature

description: This paper will follow the thread that may be traced in Derrida's Mal d’Archive when the title is translated as "The Archive Bug."
In so doing, it will attempt to describe the ways in which the death drive as it appears in Mal d’Archive may be related to the (non-)concept of différance as it has emerged in Derrida's theoretical writings under various names. The argument will hinge on the thinking of différance as a virus, in the sense of an (anti-)information (non-)entity which propagates by entering a genetic structure and substituting elements of its code.
Michel Houellebecq: A Lyric Poet in the Era of Late Capitalism
Creators: name: Jack, David
Publisher: name: Monash University
Year: 2017
Subjects: subject: 200599 Literary Studies not elsewhere classified
subject: FOS: Languages and literature

description: Michel Houellebecq is best known for his novels, particularly Les Particules élémentaires, with which he achieved literary fame in the late nineteen nineties. However, Houellebecq began his creative life as a poet and a writer of occasional pieces for obscure literary journals. The first of these was a magazine he founded himself, Karamazov, devoted almost entirely to poetry. Following this, he went on to publish three short collections of poetry, mostly in the lyric style, prefaced by a manifesto entitled Rester vivant [Staying Alive]. Somewhat surprisingly, given Houellebecq's notoriety, and given the publishing house's taste for scandal, these three volumes have never really seen the light of day outside France. This has as much to do with the almost absolute unmarketability of lyric poetry today as it does a certain change in the structure of experience which has affected our capacity to receive lyric poetry, perhaps irrevocably. In his essay on Baudelaire, Walter Benjamin writes: "If conditions for the positive reception of lyric poetry have become less favorable, it is reasonable to assume that only in rare instances is lyric poetry in rapport with the experience of its readers." For just as it was with Baudelaire, the last great lyric poet, certain motifs in Houellebecq's poetry continue to render the lyric form increasingly dubious.
Cranial anatomy of an Eocene notoungulate mammal from northwestern Argentina with special reference on the ear region
Creators: name: García-López, Daniel A.
name: Babot, Judith
name: González, Rodrigo
name: Scanferla, Agustín
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: A detailed anatomical analysis is here presented focused on a notoungulate skull recovered from sediments of the lower part of the Quebrada de los Colorados Formation (LC I; late middle Eocene), cropping out in Salta Province, Argentina. The material was identified as a Toxodontia, although it does not exhibit information useful enough for its generic or even familiar assignment. The description was mainly focused on the basicranium and the auditory region (especially the petrosal and auditory ossicles) given the better preservation of these parts in the specimen. Additionally, a phylogenetic analysis was conducted based on previous studies dealing with a wide sample of South American Native Ungulates. This specimen exhibits some traits traditionally mentioned for the suborder Toxodontia, such as the horizontal bullar septum, and others recently regarded as synapomorphies of Notoungulata, including the lateral location of the tensor tympani fossa and the expanded medial margin of the petrosal. However, it also shows some unexpected features for that suborder of notoungulates, such as the presence of a strongly curved promontorium. The study of this skull increases our knowledge of the auditory anatomy of Eocene Toxodontia and yields a good opportunity to test current phylogenetic hypothesis, mostly based on Neogene representatives.
Thirdnesses: Creative Cognition in Andrei Bely's Symbolist Metaphysics and the Semiotics of Peircean Epistemology
Creators: name: Funari, Rachel
Publisher: name: Monash University
Year: 2017
Subjects: subject: 200599 Literary Studies not elsewhere classified
subject: FOS: Languages and literature

description: Tripartite models of existence are as old as Western philosophy itself. Aristotle conceived of existence as form and matter united in substance, while Christianity defines the Trinity as Father, Son and Holy Spirit. Both phenomenological and epistemological systems use trichotomies to explain the ineffable, for example psychology (Ego, Id and Superego) and linguistics (signifier, signified, sign). Whether the ineffable ñ cause, meaning, origin, truth – be conceived of as metaphysical and divine or merely immaterial and unknowable, reality is usually understood in opposition to it. This essay demonstrates how a metaphysical theory, Andrei Bely's symbolism, and an epistemological theory, C S Peirce's semiotics, both figure reality as an activity of the human subject, a welding of sense and thought that is much more a realisation of the ineffable than in opposition to it. For these thinkers, without the welding of immaterial and material through a human act of embodiment, there is no experience of the world. In their foreword to volume one of The Essential Peirce, Nathan Houser and Christian Koesel note that the collected essays of the book were written "while Peirce's real- ism was limited to a single universe, that of thirdness – or the world of thought." This third world of thought is also the realm of reality for Bely.
A new modified sesquiterpene glycoside from Cupressus chengiana
Creators: name: Lin, Yan
name: Li, Yan
name: Li, Rong-Jiao
name: D. McGarvey, Brian
name: Wu, Hai-Feng
name: Wang, Xiao-Ling
Publisher: name: Taylor & Francis
Year: 2014
Subjects: Uncategorised

description: A new sesquiterpene glycoside, cupressusoside (1), and five known compounds were isolated from the 70% aqueous ethanol extract of the branches and leaves of Cupressus chengiana. Their structures were elucidated by using spectroscopic methods. All the isolates expressed no remarkable cytotoxic activity against colon carcinoma (HCT-8) and breast cancer (MCF-7) cell lines, with IC50>40 mg/mL.