Genetic instruments for drug targets MR analysis
Creators: name: Jiang, Deming
Publisher: name: Zenodo
Year: 2024

description: This repository contains the genetic instruments used in 'Genetic insights into drug targets for sporadic Creutzfeldt-Jakob disease: Integrative multi-omics analysis'.  If you use these files, you need to cite this article and relevant primary references (see Table S1 in reference 1).

References you need to cite:



Jiang D, Nan H, Chen Z, Zou WQ, Wu L. Genetic insights into drug targets for sporadic Creutzfeldt-Jakob disease: Integrative multi-omics analysis. Neurobiol Dis. 2024 Jul 10:106599. doi: 10.1016/j.nbd.2024.10659.

Wingo AP, Liu Y, Gerasimov ES, Vattathil SM, Liu J, Cutler DJ, Epstein MP, Blokland GAM, Thambisetty M, Troncoso JC, Duong DM, Bennett DA, Levey AI, Seyfried NT, Wingo TS. Sex differences in brain protein expression and disease. Nat Med. 2023 Sep;29(9):2224-2232. doi: 10.1038/s41591-023-02509-y.

Qi T, Wu Y, Fang H, Zhang F, Liu S, Zeng J, Yang J. Genetic control of RNA splicing and its distinct role in complex trait variation. Nat Genet. 2022 Sep;54(9):1355-1363. doi: 10.1038/s41588-022-01154-4.

Wang D, Liu S, Warrell J, et al.Comprehensive functional genomic resource and integrative model for the human brain. Science. 2018 Dec 14;362(6420):eaat8464. doi: 10.1126/science.aat8464.

GTEx Consortium. The GTEx Consortium atlas of genetic regulatory effects across human tissues. Science. 2020 Sep 11;369(6509):1318-1330. doi: 10.1126/science.aaz1776.



Fujita M, Gao Z, Zeng L, et al. Cell-subtype specific effects of genetic variation in the aging and Alzheimer cortex. Published online November 8, 2022:2022.11.07.515446. https://www.biorxiv.org/content/10.1101/2022.11.07.515446v1.


Bryois J, Calini D, Macnair W, Foo L, Urich E, Ortmann W, Iglesias VA, Selvaraj S, Nutma E, Marzin M, Amor S, Williams A, Castelo-Branco G, Menon V, De Jager P, Malhotra D. Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders. Nat Neurosci. 2022 Aug;25(8):1104-1112. doi: 10.1038/s41593-022-01128-z.

Võsa U, Claringbould A, Westra HJ, et al. Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression. Nat Genet. 2021 Sep;53(9):1300-1310. doi: 10.1038/s41588-021-00913-z.

Qi T, Wu Y, Zeng J, et al. Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood. Nat Commun. 2018 Jun 11;9(1):2282. doi: 10.1038/s41467-018-04558-1。

Wu Y, Zeng J, Zhang F, Zhu Z, Qi T, Zheng Z, Lloyd-Jones LR, Marioni RE, Martin NG, Montgomery GW, Deary IJ, Wray NR, Visscher PM, McRae AF, Yang J. Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits. Nat Commun. 2018 Mar 2;9(1):918. doi: 10.1038/s41467-018-03371-0.

Wingo AP, Liu Y, Gerasimov ES, et al. Sex differences in brain protein expression and disease. Nat Med. 2023 Sep;29(9):2224-2232. doi: 10.1038/s41591-023-02509-y.

Robins C, Liu Y, Fan W, Duong DM, Meigs J, Harerimana NV, Gerasimov ES, Dammer EB, Cutler DJ, Beach TG, Reiman EM, De Jager PL, Bennett DA, Lah JJ, Wingo AP, Levey AI, Seyfried NT, Wingo TS. Genetic control of the human brain proteome. Am J Hum Genet. 2021 Mar 4;108(3):400-410. doi: 10.1016/j.ajhg.2021.01.012.

Robins C, Liu Y, Fan W, Duong DM, Meigs J, Harerimana NV, Gerasimov ES, Dammer EB, Cutler DJ, Beach TG, Reiman EM, De Jager PL, Bennett DA, Lah JJ, Wingo AP, Levey AI, Seyfried NT, Wingo TS. Genetic control of the human brain proteome. Am J Hum Genet. 2021 Mar 4;108(3):400-410. doi: 10.1016/j.ajhg.2021.01.012.

Yang C, Farias FHG, Ibanez L, et al. Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders. Nat Neurosci. 2021 Sep;24(9):1302-1312. doi: 10.1038/s41593-021-00886-6.

Zheng J, Haberland V, Baird D, et al. Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases. Nat Genet. 2020 Oct;52(10):1122-1131. doi: 10.1038/s41588-020-0682-6.

Sun BB, Chiou J, Traylor M, et al. Plasma proteomic associations with genetics and health in the UK Biobank. Nature. 2023 Oct;622(7982):329-338. doi: 10.1038/s41586-023-06592-6.

Yang C, Farias FHG, Ibanez L, et al. Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders. Nat Neurosci. 2021 Sep;24(9):1302-1312. doi: 10.1038/s41593-021-00886-6.