cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Adhesins of Streptococcus sanguinis that promote infective endocarditis through interactions with platelets
Creators: name: Moricz, Bridget S
Publisher: name: University of Iowa
Year: 2024
Subjects: Infective endocarditis
pbrA
RTX
Streptococcus sanguinis
type IV pili
public abstract

description: Infective endocarditis (IE) is a bacterial infection of the heart. For IE to occur the heart valve must be injured or inflamed, which can arise from congenital heart disease, rheumatic heart disease, intravenous drug use, or the presence of an artificial valve. Bacteria can stick to multiple factors at the site of injury and grow into biofilm-like masses called vegetations. These vegetations can impair heart function and break off, causing blood clots (emboli) throughout the body. IE is associated with a high mortality rate even with treatment. How bacteria cause this disease is relatively unknown and understudied. We set out to look for factors that the bacterium, Streptococcus sanguinis, use to cause IE. We created mutant strains in sixteen different genes that were unable to function in various tests that mimic IE progression. Three of these factors were tested in an animal model and found to be unable to cause disease. We characterized two of these factors in more detail. The first factor, PbrA, is a unique protein that cleaves itself, is surface associated, and interacts with platelets. The other factor is a type IV pili (T4P) system, which is composed of small proteins that are extended out of the bacteria and can be retracted back and one of its functions is to mediate twitching motility. We found that T4P are needed to produce a platelet-dependent biofilm as well as invade aortic endothelial cells. Together this work improves our understanding on how S. sanguinis causes IE and provides foundations for future research in the development of preventatives and treatments.
La otredad suburbana en la narrativa peruana entre 1950 y 1992
Creators: name: Abanto, Luis
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Language, Modern.
subject: Literature, Latin American.

description: Since the 1950's, Peru has moved from a rural to an urban society. Rural migration caused a demographic explosion and emerging shantytowns ( barriadas) in peripheral areas of Lima, where a third of Peru's population currently resides. This phenomenon has transformed Lima's Hispanic character. The main actors of this process, referred to in this study as otro suburbano, were mostly Andean-peasant migrants and marginal urban individuals. Together, they built barriadas and occupied traditional urban spaces, and were considered as suburban groups excluded from the conventional city. Despite Peruvian literature's mimetic tradition, critics have stated that Peruvian writers have lacked interest in this phenomenon. This dissertation demonstrates that, by applying the concept of otredad suburbana, we find, in fact, significant relations between Lima's urban transformation and fictional stories. The focus of this study is the configuration of the otredad suburbana in Peruvian narrative between 1950 and 1992 through the analyses of eight short stories, three novels and one nouvelle, written respectively by Huanay, Congrains, Ribeyro, Bonilla, Salazar Bondy, Urteaga, Jara, and Higa. This study is divided into four parts corresponding to four points of view depicting the otro suburbano: (1) Andean-migrant (the other from the margin), (2) Urban-criollo (the other from the centre), (3) Emerging-migrant (the other and the hybridizing centre), and (4) Contemporary-urban (the other and the suburbanizing centre). Considering the literary text as the vehicle of an author's ideology, analyses are based on semiotic-narratological concepts (Bal, Genette, Lanser) and supported by categories from sociological and cultural studies (Comejo Polar, Lauer, Matos Mar, Nugent, Romero). This dissertation concludes that, (1) the otro suburbano, as fictional figure, appears alternately as a sublime, victimized, scatological, perturbing and tanatic subject; (2) the otro suburbano , in the narrative production, passed from being a contemplated object to being an agent of its own discourse; and (3) as a consequence of the other's massive presence, stories illustrate Lima moving towards a desuburbanizing periphery and consequently a suburbanizing centre.
Functional analysis of the carboxyl terminus of human hepatic lipase
Creators: name: Brown, Robert J
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2005
Subjects: subject: Chemistry, Biochemistry.

description: Human hepatic lipase (hHL) plays an important role in the metabolism of several lipoproteins. Unlike hHL that is mainly cell surface anchored via binding to heparan sulfate proteoglycans (HSPG), mouse HL (mHL) has a low affinity to HSPG and thus is largely blood borne. Studies have suggested that the carboxyl terminus of HL mediates cell surface binding. Recombinant hHL, mHL, and chimeric proteins (hHLmt and mHLht, in which the C-terminal 70 amino acids of hHL were exchanged with the corresponding sequence from mHL) were generated in a cell culture model. The hHL, mHL, and hHLmt proteins were catalytically active using triglyceride and phospholipid substrates. In transfected cells, the majority of hHL bound to the cell surface with only 4% of total extracellular hHL released into heparin-free media, whereas under the same conditions, 61% of total extracellular mHL were released. Like mHL, hHLmt showed decreased cell surface binding with 68% of total extracellular hHLmt released. A truncated hHL mutant (hHL471) was also generated by deleting the C-terminal five residues (KRKIR). The hHL471 also retained hydrolytic activity, and showed decreased cell surface binding with 40% of total extracellular protein released into the heparin-free media. To determine the functional role of HSPG binding by hHL in vivo, hHL and hHLmt were expressed in mice. Low levels of adenoviral expression (up to 1.8 x 10 10 virus particles per mouse) of hHL and the chimera hHLmt in C57BL/6J mice resulted in a 4- to 6-fold increase in post-heparin HL activity above uninfected mice. The hHLmt displayed reduced HSPG binding; the activity of hHLmt in pre-heparin plasma was 3-fold higher than that of hHL. In contrast to mice expressing hHL which had plasma total cholesterol and phospholipid levels comparable control mice, mice expressing hHLmt showed decreased plasma total cholesterol and phospholipids in a time-dependent manner by at least half, and the decrease was mainly attributable to HDL cholesterol and HDL phospholipids, as determined by FPLC. The reduced HDL lipids in the hHLmt-expressing mice were accompanied by markedly decreased plasma and hepatic apoA-I. In primary hepatocytes isolated from hHLmt-expressing mice, the concentration of cell-associated and secreted apoA-I were decreased by 2- to 3-fold as compared to hepatocytes isolated from control mice, whereas the levels of apoB and apoE were unaltered. Surprisingly, primary hepatocytes expressing hHLmt ex vivo had reduced secreted apoA-I but exhibited unaltered levels of cell-associated apoA-I. These data show that the C-terminal 70 amino acids of hHL play an important role in HSPG binding, and that the impaired HSPG binding of hHL has a profound HDL-lowering effect (hypoalphalipoproteinemia) in vivo.
Studies of ultracold neutron dynamics and systematic effects for the TUCAN EDM experiment
Creators: name: Vanbergen, Sean
Publisher: name: University of British Columbia
Year: 2025

description: The TRIUMF UltraCold Advanced Neutron (TUCAN) collaboration is developing a new measurement of the neutron electric dipole moment (nEDM) with the goal of improving the current best limit of dn ≤ 1.8 × 10-²⁶ ecm (90% C.L.) to the level of dn ≲ 2 × 10-²⁷ ecm (90% C.L.). A non-zero nEDM requires the violation of charge-parity (CP) symmetry, and so the measurement of the nEDM can shed light on unanswered questions of fundamental physics, such as baryon asymmetry, the strong CP problem, and extensions of the Standard Model.The first part of this dissertation relates to the development of a new source of ultracold neutrons (UCNs). This source is based on the conversion of cold neutrons produced by a dedicated spallation source to UCNs by downscattering in superfluid ⁴He. The new source will enable the desired statistical reach of the experiment. Prior to the construction of the new source, a prototype source was operated at TRIUMF from 2017 to 2019, and was used to perform experiments on UCN production, storage, and transport to assist in the design of the new source. This dissertation describes the results of a subset of those experiments, relating to the production and lifetime of UCNs in superfluid 4He. The second part of this dissertation relates to the design of the TUCAN EDM spectrometer, which implements Ramsey’s method of separated oscillating magnetic fields to search for a shift in precession frequency associated with the presence of a non-zero nEDM in a large electric field. To achieve the desired sensitivity, the spectrometer must be designed to minimize systematic uncertainties. The calculations and simulations described here demonstrate the requirements to achieve this goal. This work is largely focused on the design of the central region of the spectrometer, which contains the UCNs and applies the electric field. The work done on the central region includes the development of a prototype cell and characterization of its storage properties, simulation studies of the electric fields and impact of magnetic properties, and measurements of ferromagnetic contamination in components of the central region.
ENHANCING NURSING EDUCATION: CREATING BOOKLETS FOR SELF-DIRECTED STUDENT LEARNING
Creators: name: Hala Mahmoud Abdel-, Abdel-Halim, PhD
Publisher: name: continental journal
Year: 2024
Subjects: Self-directed learning, nursing education, intrinsic motivation, lifelong learning, student development.

description: Contemporary educational trends emphasize a shift from artificial to deep learning, from passive to active learning, and from teacher-dependent instruction to self-directed learning (SDL). In the context of nursing education, this transformation is paramount for preparing students to deliver comprehensive care to diverse patient populations. SDL equips students with the individual capabilities to plan their learning, identify suitable approaches, and discern the necessary resources and tools. SDL is underpinned by intrinsic motivation, veracity, conscientiousness, persistence, and diligence, all of which foster the development of nursing professionals. This article delves into the critical role of SDL in nursing education, shedding light on its capacity to enhance students' knowledge, skills, and professional values, ultimately enabling them to provide holistic patient care.
Relationships Between Land Use and Mercury Contamination in Twelve Tributaries of the Lake St Francis Region of the St Lawrence River near Cornwall, Ontario
Creators: name: Harrison, Sarah
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Biogeochemistry.
subject: Water Resource Management.

description: In the environment, oxidized mercury (Hg) can be converted to more toxic chemical species, such as methylmercury (MeHg), as a result of both abiotic and biotic reactions. Hg and MeHg are present in aquatic ecosystems that flow into the Lake St. Francis region of the St. Lawrence River, but their origin is still being debated. A study of mercury and methylmercury contamination in Lake St. Francis in cooperation with the Raisin Region Conservation Authority (RRCA) is ongoing, in collaboration with the Ontario Ministry of Agriculture, Food, and Rural Affairs (OMAFRA) and the Great Lakes Program. A recent report detailed the experimental results for one portion of the area of concern, the Raisin River. The goal of the present project is to update and expand upon the previous work in order to include other existing and new data for this river and several other watercourses feeding Lake St. Francis. Special attention was paid to the MeHg hotspots in an attempt to link methylation and subsequent mobilization to different types of land use and nutrient profiles compiled from new and existing data. It was predicted that water draining off wetlands would have higher MeHg concentrations than water from catchments with other land use profiles. Total and methylmercury were expected to be correlated to the concentrations of nitrogen compounds, sulfate, phosphorus, dissolved inorganic carbon (DIC), and especially dissolved organic carbon (DOC). However, wetlands could not be correlated to MeHg as predicted but the area of crop land was correlated positively with the percentage of THg present as MeHg. Forest and impermeable areas were associated with a decrease in mercury. There was no difference in mercury during wet years compared to dry years when compared on an annual basis, but a significant seasonal difference exists between the two categories. MeHg was positively correlated to DOC, NH3, and BOD. THg was positively correlated to BOD, TSS, Escherichia coli, and fecal coliforms. The percentage of THg present as MeHg (%MeHg) was positively correlated to phosphorus. There were also some statistically significant negative correlations. Forest and impermeable area were negatively correlated with the quantity of MeHg, and impermeable area was negatively correlated with %MeHg. Greater predictor strength and more numerous significant correlations are expected under more thorough sampling and more data.
The multicultural Internet - parallel worlds?: Review of Gerard Goggin and Mark McLelland (Eds.), Internationalizing Internet Studies
Creators: name: Gerrand, Peter
Publisher: name: Swinburne
Year: 2024

description: Review of Internationalizing Internet Studies. Beyond Anglophone Paradigms, edited by Gerard Goggin and Mark McLelland. (Routledge, New York, 2009).
Marina Köhn, Umweltbundesamt, zur Energie-Effizienz und Nachhaltigkeit im Rechenzentrum
Creators: name: Lutz, Harald
Publisher: name: My University
Year: 2022

description: Die Europäische Union zieht die Zügel an, um die im Pariser Abkommen gesteckten Klimaziele zur Begrenzung der Erderwärmung auf maximal 1,5 Grad zu erreichen. Über sowohl freiwillige als auch gesetzlich einzufordernde Beiträge der Datacenter-Branche, über Gemeinsamkeiten und Unterschiede im Vergleich mit anderen Industrien sowie über den aktuellen Projektstand etwa von "PeerDC" und der Aktualisierung des "Blauen Engel", äußert sich Marina Köhn vom Umweltbundesamt. Quelle: https://www.datacenter-insider.de/
Introduction of the Charité Mobility Index (CHARMI) – A Novel Clinical Mobility Assessment for Acute Care Rehabilitation
Creators: name: Liebl, Max E.
name: Elmer, Nancy
name: Schroeder, Isabelle
name: Schwedtke, Christine
name: Baack, Angelika
name: Reisshauer, Anett
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Introduction Mobility is an essential part of a person’s functioning and independence. It encompasses locomotive functions, but also the more basic functions of positioning and transferring. Despite the availability of several mobility-related assessment instruments to date, there is a need for assessment instruments with the specific capability to display the full range of mobilisation. Our aim was to develop and validate a scoring instrument with hierarchical composition where every score value stands for a defined mobility level. Participants and Methods A previously developed and validated pilot instrument was applied to assess patients (n = 113) admitted to an acute rehabilitation programme. Mobility was assessed during admission, subsequently at weekly intervals and at discharge to acquire a detailed status of mobility at multiple time points and individual mobilisation profiles over time. The scoring instrument was then remodelled based on clinical criteria to establish an easy-to-use scoring system with hierarchical composition. Psychometric properties were calculated using an independent sample of 87 consecutive patients. Results Content validity could be affirmed. The psychometric tests demonstrated excellent convergent validity with the three mobility items of the Barthel Index (r = 0.93), despite an adequately lower correlation with the whole Barthel Index (r = 0.63). Adequate floor and ceiling effects (20%) and a large responsiveness to change (ǀdǀ = 1.7, p < 0.001) between admission and discharge values were demonstrated. Inter-rater reliability was excellent (κ = 0.88). Conclusions The Charité Mobility Index (CHARMI) is a promising, easy- to-use hierarchical scoring instrument assessing the full individual spectrum from immobility to unlimited mobility, including positioning, transfer and locomotion items. It allows for monitoring of mobilisation.
Modélisation spatio-dynamique de la structure urbaine et du système de transport.
Creators: name: Brice, Stéphane.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1990
Subjects: subject: Geography.

description: It appears difficult to explain the spatial organization of a major urban centre without referring to its transportation system just as travel demand analysis and transport planning cannot be dissociated from the understanding of urban structure. Moreover, in economics, transportation is seen as a demand resulting from economic activities while in geography, human interactions are considered as an organizing factor rather than a product of such activities. Consequently we are interested by a modelling framework which can conciliate both realities often analysed separately. Several fundamental hindrances are therefore encountered. Transportation system analysis must initially be integrated within its own components of demand and supply. As for the urban structure, we must seek a representation suited to apprehend the spatial distribution and the evolution of several interdependent activities. Unification also requires definitions of common or at least consistent principles, standardized formulations and an adjustment of temporal scales. This attempt of integration does not imply starting over but rather using all theoretical frameworks, approaches and models concerned by urban structure and transportation. This comprehensive exercise leads to a formulation of a space-time model of a urban region. An empirical application to the Montreal metropolitain area unveils the analytical possibilities, the necessary adjustment and the limitations of this modelling.
title: Justificación de la radiografía simple de senos paranasales en la sinusitis. Controversia acerca de la necesidad de pruebas radiológicas en su diagnóstico.
Creators: name: Santos Montón, Cecilia
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Ear / Nose / Throat

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
Realizar una revisión sobre la justificación de la radiografía simple en el diagnóstico de pacientes con juicio clínico de...
National information infrastructure ubiquity: Enabling evolution
Creators: name: Heydon, Geof
name: Hunter, Mark
Publisher: name: Swinburne
Year: 2024

description: Today's broadband and Internet frameworks enable a wide variety of applications and services; from gaming to banking, distance education to online media, dating services to heath monitoring-and the rate of new applications continues to grow in function and volume. Of particular interest here is this rate of service and application creation and how such growth can be facilitated within the Australian environment - for the benefit of all Australians, as both consumers and producers of these applications.
3909822.pdf
Creators: name: Levy, Miguel
name: Borovkova, Olga
name: Sheidler, Colin
name: Blasiola, Brandon
name: Karki, Dolendra
name: Jomard, François
name: POPOVA, Olena
name: Keller, Niels
name: Kozhaev, Mikhail
name: Belotelov, Vladimir
Publisher: name: Optica Publishing Group
Year: 2019
Subjects: Uncategorized

description: Supplementary Material
Analysis of spelling skills in children who are hard of hearing using multilinguistic coding
Creators: name: Turner, Meagon A.
Publisher: name: University of Iowa
Year: 2023
Subjects: hard of hearing
hearing loss
morphological awareness
multilinguistic coding
phonological awareness
spelling
public abstract

description: Children who are hard of hearing (CHH) are at risk for difficulties with language development as well as reading and writing skills as a result of reduced or limited access to sound information. Spelling is one distinct component of written language that combines the use of phonological awareness, orthographical representations, and morphological awareness, all of which contribute to literacy and academic success. In the present study, we analyzed the frequency and types of spelling errors made by fourth grade CHH as compared to fourth grade children with normal hearing on a standardized spelling test using a multilinguistic coding system. Results showed no group differences, but students in both groups made significantly more mental graphemic representation errors than any other type of error. Future longitudinal studies are needed to provide a more detailed picture of spelling skill development among CHH and to further inform instructional methods of reading, writing, and spelling for this population.
title: Empleo del tapón vascular Amplatzer en el tratamiento endovascular de la hemorragia aguda.
Creators: name: NACARINO MEJIAS, VERONICA
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: Embolisation
subject: Catheters
subject: CT-Angiography
subject: Catheter arteriography
subject: Interventional vascular

description: Objetivos
Material y método
Resultados
Conclusiones
description: Objetivos:
Demostrar la utilidad de los tapones vasculares (TV) tipo Amplatzer en el tratamiento endovascular de pacientes con hemorragia aguda. Presentamos nuestra experiencia. INTRODUCCIÓN: Los TV Amplatzer son unos dispositivos autoexpandibles recubiertos...
Terahertz microjets and graphene : technologies towards ultrafast all-optical modulation
Creators: name: Geoffroy-Gagnon, Simon
name: Bergen, Mark Henry
name: Born, Brandon
name: Holzman, Jonathan F.
Publisher: name: IEEE
Year: 2018

description: Key technologies for ultrafast all-optical THz modulation are introduced. A graphene monolayer is applied for modulation, on a picosecond timescale, and a dielectric sphere is applied to form a high-intensity THz microjet within the graphene monolayer.
title: Criterios de respuesta para linfoma
Creators: name: Gálvez González, Esther
Publisher: name: Sociedad Española de Radiología Médica
Year: 2012
Subjects: subject: CT
subject: PET-CT
subject: Education
subject: Comparative studies
subject: Lymphoma

description: Objetivo docente
Revisión del tema
Conclusiones
description: Objetivo docente:
El linfoma es una patología muy prevalente la cual ha dado lugar al desarrollo de muchas terapias.
Para poder comparar la efectividad entre dichos tratamientos se han desarrollado unos criterios por el IWG “International Working Group”,
que...
3935984.pdf
Creators: name: Sterczewski, Lukasz
name: Westberg, Jonas
name: Yang, Yang
name: Burghoff, David
name: Reno, John
name: Hu, Qing
name: Wysocki, Gerard
Publisher: name: Optica Publishing Group
Year: 2019
Subjects: Uncategorized

description: Supplement 1 - supplementary information to ”Terahertz hyperspectral imaging with dual chip-scale combs"
The roles of L-type calcium channels in behavior and cerebellar structure
Creators: name: Klomp, Annette
Publisher: name: University of Iowa
Year: 2024
Subjects: Behavior
Calcium
L-type Channels
Sex Differences
Cerebellum
Morphology

description: Mutations in L-type calcium channels have been associated with neuropsychiatric disorders like autism spectrum disorder, schizophrenia, and bipolar disorder. Recent work in mice has found that global knockout of the L-type calcium channels CaV1.2 and CaV1.3 each result in social, motor, and cognitive impairments; however, it is unclear how a loss of CaV1 channels leads to behavioral impairments. The goal of this work is to use multiple conditional knockout mouse models to understand the specific roles of CaV1.2, CaV1.3 and α2δ-4 in the brain. From this work, we established that a global knockout of the L-type channel subunit α2δ-4 is sufficient to cause impairments in cognitive and motor behaviors. We established that a neuron-specific knockout of CaV1.2 is sufficient to cause impairments in cognitive, motor, and social behaviors. We found that a global knockout of CaV1.3 does not alter most measures of cerebellar cortex morphology but does result in less complexity in the dendrites of Purkinje cells, the primary output neuron of the cerebellar cortex. Finally, we established that a conditional deletion of CaV1.3 from ~25% of cerebellar molecular layer interneurons is sufficient to impair motor learning behaviors. Together, this work contributes to our understanding of the complex role L-type channels play in the brain. Given the genetic links between L-type channels and neuropsychiatric disorders, a better understanding of the role of L-type channels in neuronal function may contribute to our understanding of neuropsychiatric disorders.
The construction of homosexuality in Christian tradition and its influence on the meaning of AIDS: A psychological study.
Creators: name: Mills, Bruce L.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1991
Subjects: subject: Religion, History of.

description: This thesis addresses two fundamental questions: What is the meaning given to Acquired Immune Deficiency Syndrome (AIDS)? Where does the meaning of AIDS come from? In a psychological investigation it appears that the most predominant meaning given to AIDS is homophobic meaning, expressing a profound fear and dread of homosexuality. Homophobia can be traced to two main historical sources. Both of these sources are located within Christian tradition: the Sodom story (Genesis XIX), and discourse on human sexuality originating in the New Testament writing of Paul. These two sources can be shown to influence many attitudes that are expressed in this society towards homosexuality generally and towards the AIDS epidemic in particular. Homophobic attitudes situated in the context of western society seem to exist in close proximity with prevalent Christian definitions of homosexuality. Much of the meaning given to homosexuality within Christian tradition can be followed as it influences moral systems, psychiatry and homosexual experience itself. The understanding of homosexuality which develops in much Christian tradition seems to provide a central point of reference for the ways homosexuality is perceived and experienced. A psychodynamic model also ascertains that homophobia is partially structured in the unconscious as a form of prohibition against homosexual desire. By taking both conscious and unconscious aspects of homophobia into consideration, the meaning of AIDS and some of the sources of this meaning can be put forward. The meanings which predicate the AIDS epidemic are religious and psychological in nature. By taking homophobia apart with the tools of psychological deconstruction, the meaning of AIDS may be approached, and some of the implications of this meaning for society, for Christian tradition and for the homosexual person may be demonstrated.
Incidence of orbital, conjunctival and lacrimal gland malignant tumors in USA from Surveillance, Epidemiology and End Results, 1973-2009
Creators: name: Hassan, Waleed M.
name: Bakry, Mohamed S.
name: Hassan, Housam M.
name: Alfaar, Ahmad S.
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: orbital tumors
subject: incidence
subject: conjunctiva
subject: lacrimal gland
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: AIM: To determine the types and incidence of tumors affecting the orbit, conjunctiva and lacrimal glands and to study the trend line of these tumors in the United States from 1973 to 2009. METHODS: We used the publicly available Surveillance, Epidemiology and End Results (SEER) database registries to determine the incidence rates. Age was adjusted to the 2000 US Standard Population. Patients were stratified according to age group, gender, race and histological grouping of tumor lesions. Three age groups were defined: 0-19, 20-49 and ≥50y. Annual percentage changes were calculated to examine trends. RESULTS: The overall age adjusted incidence rate was 3.39 (95%CI: 3.27-3.52) per million person-years. The tumors were more prevalent in age group ≥50 counting 9.51 (95%CI: 9.11-9.92) per million person-years. Most of the soft tissue sarcomas occurred in the young age with incidence rate of 0.35 (95%CI: 0.28-0.42) per million person-years. Lymphomas were the dominant subtype in the adult population with incidence rate of 5.74 (95%CI: 5.43-6.06) per million person-years. Incidence rates were higher in males than females with an overall rate ratio of 1.31 (95%CI: 1.21-1.41) mainly caused by the increase in carcinoma subtypes. White race had a higher tumor incidence with a rate ratio of 1.47(95%CI: 1.25-1.73) driven by the higher incidence of most histological subtypes. Orbital tumors showed a higher incidence rate followed by conjunctival and lacrimal gland tumors with incidence rates of 1.59, 1.37 and 0.43 per million person-years respectively. The trend line of overall incidence of tumors showed a significant increase (APC=3.11, 95%CI: 2.61-3.61) mainly due to increase of lymphomas. This increase was higher than the increase of lymphomas at other sites. CONCLUSION: Orbital, conjunctival and lacrimal gland malignant tumors differ among children and adults. Over the years there has been a noticeable increase in incidence rates of orbital and lacrimal gland tumors mainly caused by an increase in lymphomas and an apparent increase due to advances in diagnostic techniques. ICD-O-3 topographical coding should be improved to consider the different orbital bones and ocular structures.
Eco-evolutionary consequences of colonization by a controphic competitor : competitive exclusion or coexistence?
Creators: name: Duchesne, Megan
Publisher: name: University of British Columbia
Year: 2025

description: Novel interactions among native and colonist species are now common due to range shifts in response to climate and land use change, but few studies of native populations are sufficiently detailed or long to document reliably their evolutionary and demographic responses to colonization by controphic competitors. I emulated a classic study of competition, rapid evolution, and coexistence in Galapagos Finches (Geospiza) to test if the colonization of XOXDEL (Mandarte I), British Columbia, Canada, by Fox Sparrows (Passerella iliaca unalaskensis), a dominant controphic competitor to the native Song Sparrow (Melospiza melodia) resident there, led to directional selection on bill size or shape and subsequent convergence on or divergence from bill morphology of Fox Sparrows over 49 years (1975-2023). To do so, I used 3,991 captures of 1,554 adult and yearling Song Sparrows to test for natural selection and morphological evolution. Survival increased with bill size in adult and yearling males and yearling females on average, effectively truncating distributions in adult male and female breeders that hatched locally. However, despite strong directional selection and positive relationships between annual selection differentials and change in the mean bill size and shape of breeding adults across years, I did not observe divergence or convergence in the bill sizes or shapes of Song and Fox Sparrows. Although I also predicted that the intensity of natural selection on bill morphology would increase with the density of intra- and/or interspecific competitors, those predictions were not supported. I did not find support for the hypothesis that large bills enhance survival by reducing heat stress. While ecological conditions were situationally similar to those described by Grant & Grant (2006), patterns of natural selection and morphological change remained unpredictable despite substantial variation in individual phenotype, survival, and competitor density. My results advance understanding by providing clear examples of the influence of natural selection on bill morphology in a small, insular population of Song Sparrows that was colonized by a superior competitor for seeds in 1975 but declined to extinction over the subsequent half-century.
The influence of United States-Soviet differences on press coverage of terrorism: A comparison of "The New York Times" and "Izvestia".
Creators: name: Skabas, Radoslaw.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Journalism.

description: This paper examines the differences between the coverage accorded to incidents of transnational terrorism by the press of the United States and the Soviet Union. Two elite daily newspapers are compared: The New York Times and Izvestia. The coverage of two incidents of transnational terrorism is analyzed (1985 TWA airliner hijacking and 1985 kidnapping of four Soviet diplomats; both incidents took place in Beirut) in which nationals of both countries were involved. It is assumed, that "political distance"--the attitude towards the perpetrators and the victims--will influence the coverage. Findings indicate two different patterns in the coverage, which reflect the fundamental differences between the two papers in their perception of the role of the mass media in their respective societies. This raises more general questions of an ethical nature relating to the role and responsibilities of the media towards their audiences and towards the state.
Reduction of environmental risks from the use of biocides: Environmental sound use of disinfectants, masonry preservatives, and rodenticides
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2015
Subjects: subject: Risikowahrnehmung
subject: biocides
subject: sustainable use
subject: pesticides
subject: integrated pest management
subject: best practice
subject: risk awareness
subject: Chemikalien
subject: Chemicals

description: In November 2009 a framework action plan for achieving a sustainable use of pesticides was established by Directive 2009/128/EC on the basis of the corresponding Thematic Strategy. It aims at minimising hazards and risks for human health and the environment. This is accomplished by improving the controls of pesticide application, their distribution and by encouraging cultivation methods with limited use of pesticides. This shall be achieved by supporting "good practicesŁ and by integrated pest management as well as by use restrictions in sensitive areas. Up to now the sustainable use of pesticides Directive (SUD) has focused on plant protection products. However, the possibility for extending the Directive to biocides is kept open.
Quelle: www.umweltbundesamt.de

description: In November 2009 a framework action plan for achieving a sustainable use of pesticides was established by Directive 2009/128/EC on the basis of the corresponding Thematic Strategy. It aims at minimising hazards and risks for human health and the environment. This is accomplished by improving the controls of pesticide application, their distribution and by encouraging cultivation methods with limited use of pesticides. This shall be achieved by supporting „good practices” and by integrated pest management as well as by use restrictions in sensitive areas. Up to now the sustainable use of pesticides Directive (SUD) has focused on plant protection products. However, the possibility for extending the Directive to biocides is kept open.
Broadband and network environmentalism: The case of One Million Acts of Green
Creators: name: Biggar, Jeff
name: Middleton, Catherine
Publisher: name: Swinburne
Year: 2024

description: Global focus on reaching emission reduction targets has shed light on the significance of household contributions to greenhouse gas (GHG) emissions. At the consumer level, 'going green' has become a popular trend aimed at curbing environmental impact and living in more sustainable ways. This paper explores the ways in which individuals are addressing these realities and adopting new lifestyle choices through broadband-enabled social networking initiatives. Presenting a case study of current practices to support sustainability using broadband networks, this paper demonstrates that an understanding of motivations, barriers to participation, and other factors determine the success of environmental campaigns.
Asymptotically tight performance bounds for equal-gain combining over a new correlated fading channel
Creators: name: Olutayo, Adebola
name: Cheng, Julian
name: Holzman, Jonathan F.
Publisher: name: IEEE
Year: 2018

description: A recently proposed fading model which can be used to describe both line-of-sight and non-line-of-sight components of a fading channel is analyzed. The outage probability and error rate performance of equal-gain combining over arbitrary correlated Beaulieu-Xie fading channels is considered. Asymptoticallytight closed-form lower and upper bounds are derived and these analytical results are verified via Monte Carlo simulations.
Immunochip analysis identifies association of the RAD50/IL13 region with human longevity
Creators: name: Flachsbart, Friederike
name: Ellinghaus, David
name: Gentschew, Liljana
name: Heinsen, Femke-Anouska
name: Caliebe, Amke
name: Christiansen, Lene
name: Nygaard, Marianne
name: Christensen, Kaare
name: Blanche, Helene
name: Deleuze, Jean-Francois
name: Derbois, Celine
name: Galan, Pilar
name: Buening, Carsten
name: Brand, Stephan
name: Peters, Anette
name: Strauch, Konstantin
name: Mueller-Nurasyid, Martina
name: Hoffmann, Per
name: Noethen, Markus M.
name: Lieb, Wolfgang
name: Franke, Andre
name: Schreiber, Stefan
name: Nebel, Almut
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2016
Subjects: subject: 5q31.1
subject: genetic association
subject: human longevity
subject: IL13
subject: Immunochip
subject: RAD50
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

description: Human longevity is characterized by a remarkable lack of confirmed genetic associations. Here, we report on the identification of a novel locus for longevity in the RAD50/IL13 region on chromosome 5q31.1 using a combined European sample of 3208 long-lived individuals (LLI) and 8919 younger controls. First, we performed a large-scale association study on 1458 German LLI (mean age 99.0 years) and 6368 controls (mean age 57.2 years) by targeting known immune-associated loci covered by the Immunochip. The analysis of 142 136 autosomal single nucleotide polymorphisms (SNPs) revealed an Immunochip- wide significant signal (PImmunochip = 7.01 × 10–9) for the SNP rs2075650 in the TOMM40/APOE region, which has been previously described in the context of human longevity. To identify novel susceptibility loci, we selected 15 markers with PImmunochip < 5 × 10–4 for replication in two samples from France (1257 LLI, mean age 102.4 years; 1811 controls, mean age 49.1 years) and Denmark (493 LLI, mean age 96.2 years; 740 controls, mean age 63.1 years). The association at SNP rs2706372 replicated in the French study collection and showed a similar trend in the Danish participants and was also significant in a meta-analysis of the combined French and Danish data after adjusting for multiple testing. In a meta-analysis of all three samples, rs2706372 reached a P-value of PImmunochip+Repl = 5.42 × 10−7 (OR = 1.20; 95% CI = 1.12–1.28). SNP rs2706372 is located in the extended RAD50/IL13 region. RAD50 seems a plausible longevity candidate due to its involvement in DNA repair and inflammation. Further studies are needed to identify the functional variant(s) that predispose(s) to a long and healthy life.
Thermal management of avionics systems : analysis of advanced avionics modules through modelling and optimization
Creators: name: Amedu, Ojogbane
Publisher: name: University of British Columbia
Year: 2025

description: Thermal management challenges in modern avionics systems are increasing due to rising power densities, compact designs, and complex integration requirements. Avionics systems are at risk of overheating, being throttled, and eventually shrinking those systems operational lifespan. Industry standards such as DO-160G impose stringent thermal performance requirements, making it essential to develop accurate predictive models and efficient optimization strategies for avionics bay layouts. This thesis presents a systematic evaluation of numerical modeling simplifications in avionics thermal analysis, assessing the impact of geometric approximations, airflow blockage, and system interactions on predictive accuracy. Geometric simplifications were analyzed by comparing detailed and simplified representations of avionics units in computational models. The results demonstrate that while component detail increases the accuracy of a model, simplified geometries provide an adequate representation for practical applications. Using simple rectangular blocks to model airflow blockage was found to be an ineffective solution, decreasing the relative accuracy of predictions. Heat flux wall boundary conditions were used to represent the heat transfer between adjacent units, showing that models which ignore surrounding avionics present inaccurate solutions that underpredict the thermal risk of an avionics unit in a real avionics bay. These findings were validated through experimental analysis using a controlled avionics test chamber. Notably, validated modeling revealed simpler, more cost-effective cooling designs for avionics units. In addition to numerical model evaluation, this research leverages the Thermal Risk Approach (TRA) for avionics bay optimization. TRA is incorporated into four optimization methodologies; Score Minimization Method (SMM), Min-Max Method, Multi-Objective Analysis (MOA), and Weighted Risk Scoring (WRS) that use separate criteria to determine the ideal placement of units inside an avionics bay. A Multi-Level Selection Genetic Algorithm (MLSGA) utilizing these methodologies was developed, providing a robust, scalable tool for optimizing complex avionics bays. Comparative analyses were conducted between optimized and randomly generated layouts using SMM, Min-Max, MOA, WRS and MLSGA methodologies. The MLSGA approach generated substantial reductions in the number of high-risk units and the average surface temperature for units in a complex avionics bay environment. This work provides a foundation for more efficient and reliable thermal management strategies in modern avionics systems.
The behaviour of flowthrough rockfill dams.
Creators: name: Hansen, David.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 1992
Subjects: subject: Engineering, Civil.

description: This thesis deals with the hydraulics and stability of "flowthrough" rockfill embankments. This thesis provides new information in the following seven areas: (1) A multi-disciplinary consideration of most of the available equations describing one-dimensional non-Darcy flow. Such flow is characterized by a non-linear dependence of velocity on the hydraulic gradient. New data is presented to assist in the evaluation of the effect of particle irregularity, as compared to perfect spheres. (2) A new computational method to estimate the quantity of flow moving through a rockfill embankment, as a function of the upstream water level, is presented. (3) If some minimum upstream water level is required, an impermeable element (in the form of a wall-like hydraulic barrier) will be needed. The hydraulics of an upstream impermeable facing (UIF) was studied in this research program. Some guidance is presented as to how to account for the effect of an elevated downstream water level on the stage-discharge rating curve of a flowthrough rockfill embankment. (4) Three distinct analytical methods for computing the position of the phreatic line are presented and evaluated. The validity of the Dupuit assumption, which is inherent in all three of the analytic methods, is also discussed. (5) A detailed computational framework is presented to make possible the prediction of the minimum elevation over which mesh protection is needed to prevent erosion of the downstream face of the dam. (6) The possibility of massive deep-seated failure was investigated in detail. As a first step to permit such evaluations, non-Darcy pore-pressure modelling was performed. An efficient method for executing such modelling on an electronic spreadsheet is presented. In an innovative series of experiments it was found that the measured bursting force at incipient failure was far closer to that theoretically predicted by the wedge method than that predicted by a classical rotational slip-circle method (Bishop's Simplified Method). (7) In another innovative series of experiments, this low-temperature behaviour was investigated using the Low Temperature Laboratory of the National Research Council of Canada. Based on this research a simple method for estimating the rate of growth of ice at the phreatic surface is presented. Ice was not observed to form in the voids within the body of the dam, except in one case in a small mixing zone (the base of Parkin's zone 3) below the lip of the UIF. A detailed theoretical framework for performing heat budget calculations is also presented, together with a short computer program to facilitate these calculations. It is quantitatively demonstrated that the viscous dissipation of hydraulic energy plays an important role in preventing ice formation in the voids. (Abstract shortened by UMI.)
CLINICAL CHARACTERISTICS OF CHRONIC PURULENT RHINOSINUSITIS IN PATIENTS WITH OBESITY
Creators: name: Nosirjonov, M.A.
Publisher: name: Zenodo
Year: 2024

description: Chronic purulent rhinosinusitis (CPRS) is one of the most prevalent upper respiratory tract diseases, with a significant impact on patients, particularly when combined with metabolic disorders such as obesity. Obesity, as part of metabolic syndrome (MS), exacerbates the clinical course of CPRS by promoting systemic inflammation and immune dysfunction. This study aims to analyze the clinical, immunological, and biochemical features of CPRS in patients with and without metabolic syndrome.