cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Comparison of registered and published outcomes in randomized controlled trials: a systematic review
Creators: name: Keil, Lukas G
name: Holland, Wesley C
name: Platts-Mills, Timothy
name: Caughey, Melissa C
Publisher: name: BioMed Central
Year: 2015

description: Abstract Background Clinical trial registries can improve the validity of trial results by facilitating comparisons between prospectively planned and reported outcomes. Previous reports on the frequency of planned and reported outcome inconsistencies have reported widely discrepant results. It is unknown whether these discrepancies are due to differences between the included trials, or to methodological differences between studies. We aimed to systematically review the prevalence and nature of discrepancies between registered and published outcomes among clinical trials. Methods We searched MEDLINE via PubMed, EMBASE, and CINAHL, and checked references of included publications to identify studies that compared trial outcomes as documented in a publicly accessible clinical trials registry with published trial outcomes. Two authors independently selected eligible studies and performed data extraction. We present summary data rather than pooled analyses owing to methodological heterogeneity among the included studies. Results Twenty-seven studies were eligible for inclusion. The overall risk of bias among included studies was moderate to high. These studies assessed outcome agreement for a median of 65 individual trials (interquartile range [IQR] 25–110). The median proportion of trials with an identified discrepancy between the registered and published primary outcome was 31 %; substantial variability in the prevalence of these primary outcome discrepancies was observed among the included studies (range 0 % (0/66) to 100 % (1/1), IQR 17–45 %). We found less variability within the subset of studies that assessed the agreement between prospectively registered outcomes and published outcomes, among which the median observed discrepancy rate was 41 % (range 30 % (13/43) to 100 % (1/1), IQR 33–48 %). The nature of observed primary outcome discrepancies also varied substantially between included studies. Among the studies providing detailed descriptions of these outcome discrepancies, a median of 13 % of trials introduced a new, unregistered outcome in the published manuscript (IQR 5–16 %). Conclusions Discrepancies between registered and published outcomes of clinical trials are common regardless of funding mechanism or the journals in which they are published. Consistent reporting of prospectively defined outcomes and consistent utilization of registry data during the peer review process may improve the validity of clinical trial publications.
Gravitational induced particle production through a nonminimal curvature-matter coupling
Creators: name: Harko, Tiberiu
name: Lobo, Francisco S. N.
name: Mimoso, José P.
name: Pavón, Diego
Publisher: name: arXiv
Year: 2015
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We consider the possibility of a gravitationally induced particle production through the mechanism of a nonminimal curvature-matter coupling. An interesting feature of this gravitational theory is that the divergence of the energy-momentum tensor is nonzero. As a first step in our study we reformulate the model in terms of an equivalent scalar-tensor theory, with two arbitrary potentials. By using the formalism of open thermodynamic systems, we interpret the energy balance equations in this gravitational theory from a thermodynamic point of view, as describing irreversible matter creation processes. The particle number creation rates, the creation pressure, and the entropy production rates are explicitly obtained as functions of the scalar field and its potentials, as well as of the matter Lagrangian. The temperature evolution laws of the newly created particles are also obtained. The cosmological implications of the model are briefly investigated, and it is shown that the late-time cosmic acceleration may be due to particle creation processes. Furthermore, it is also shown that due to the curvature--matter coupling, during the cosmological evolution a large amount of comoving entropy is also produced.
description: 15 pages; accepted for publication in the European Physical Journal C
МАКТАБГАЧА ЁШ ФЕНОМЕНИ
Creators: name: Ш.С. Сайфутдинов
name: Ю.К. Нарметова
Publisher: name: Central Asian Research Journal for Interdisciplinary Studies (CARJIS)
Year: 2022
Subjects: мактабгача ѐш
феномен
индивидуал
психолог
дошкольный возраст
личность
психолог.

description: Ушбу мақола мактабгача ѐшдаги боланинг психологик хусусиятлари ѐритилган. Мактабгача ѐшдаги болаларда ўзига ҳос хусусиятлари таснифлаб берилган. Психолог олимлар томонидан мактабгача ѐшдаги болаларнинг ўрганилганли кўрсатиб ўтилган. Мактабгача ѐшдаги болаларнинг феноменал хусусияти ўрганилган.
description: В данной статье рассматриваются психологические особенности ребенка дошкольного возраста. Классифицируются особенности у детей дошкольного возраста. Психологи доказали, что дети дошкольного возраста изучаются учеными. Изучена феноменальная природа детей дошкольного возраста.
First look: a cluster-randomized trial of ultrasound to improve pregnancy outcomes in low income country settings
Creators: name: Bose, Carl
Publisher: name: BioMed Central Ltd
Year: 2014

description: Abstract Background In high-resource settings, obstetric ultrasound is a standard component of prenatal care used to identify pregnancy complications and to establish an accurate gestational age in order to improve obstetric care. Whether or not ultrasound use will improve care and ultimately pregnancy outcomes in low-resource settings is unknown. Methods/Design This multi-country cluster randomized trial will assess the impact of antenatal ultrasound screening performed by health care staff on a composite outcome consisting of maternal mortality and maternal near-miss, stillbirth and neonatal mortality in low-resource community settings. The trial will utilize an existing research infrastructure, the Global Network for Women’s and Children’s Health Research with sites in Pakistan, Kenya, Zambia, Democratic Republic of Congo and Guatemala. A maternal and newborn health registry in defined geographic areas which documents all pregnancies and their outcomes to 6 weeks post-delivery will provide population-based rates of maternal mortality and morbidity, stillbirth, neonatal mortality and morbidity, and health care utilization for study clusters. A total of 58 study clusters each with a health center and about 500 births per year will be randomized (29 intervention and 29 control). The intervention includes training of health workers (e.g., nurses, midwives, clinical officers) to perform ultrasound examinations during antenatal care, generally at 18–22 and at 32–36 weeks for each subject. Women who are identified as having a complication of pregnancy will be referred to a hospital for appropriate care. Finally, the intervention includes community sensitization activities to inform women and their families of the availability of ultrasound at the antenatal care clinic and training in emergency obstetric and neonatal care at referral facilities. Discussion In summary, our trial will evaluate whether introduction of ultrasound during antenatal care improves pregnancy outcomes in rural, low-resource settings. The intervention includes training for ultrasound-naïve providers in basic obstetric ultrasonography and then enabling these trainees to use ultrasound to screen for pregnancy complications in primary antenatal care clinics and to refer appropriately. Trial registration Clinicaltrials.gov ( NCT#01990625 )
title: Vermessung von Dispersion und Elektronendynamik der NTCDA/Ag(111) Grenzflächenzustände mittels 2-Photonen-Photoemission
Creators: name: Schmidt, Benjamin
Publisher: name: Philipps-Universität Marburg
Year: 2010
Subjects: Oberflächenphysik
Dispersion
2-Photonen-Photoemission
Photoemission
Physics
Physik
NTCDA
Ag(111)

description: Vermessung der Bildpotentialzustände sowie des Interfacezustands an der NTCDA/Ag(111)-Grenzfläche im Vergleich zum wohlbekannten PTCDA/Ag(111)-Modellsystem. Untersucht werden sowohl die Dispersion als auch die Elektronendynamik der Zustände.
Effects of false performance feedback on feelings of agency and the error-related negativity
Creators: name: Hiralal, Kamil
name: van Elk, Michiel
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Cognitive Psychology
subject: Cognition and Perception
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: We conducted a follow-up study of our original study. We describe the reasons of conducting this new study, our new study design and our analysis plan. The study has already been conducted when we wrote this registration, but we haven't analysed our data before uploading this registration.
The diamidine DB75 targets the nucleus of Plasmodium falciparum
Creators: name: Purfield, Anne E
name: Meshnick, Steven R.
name: Tidwell, Richard R.
Publisher: name: BioMed Central Ltd
Year: 2009

description: Abstract Background DB289, [2,5-bis(4-amidinophenyl)furan bis-O-methylamidoxime], is a broad spectrum anti-parasitic compound which has been shown to be effective against malaria in recent clinical trials. DB75, [2,5-bis(4-amidinophenyl)furan], is the active metabolite of this drug. The objective of this study was to determine the mechanism of action of DB75 in Plasmodium falciparum. Methods Live parasites were observed by confocal microscopy after treatment with organelle specific dyes and DB75, an inherently fluorescent compound. Parasites were exposed to DB75 and assessed for growth and morphological changes over time using blood smears and light microscopy. Also, to determine if DB75 affects gene transcription, real time PCR was used to monitor transcript levels over time for six developmentally expressed genes, including trophozoite antigen R45-like (PFD1175w), lactate dehydrogenase (PF13_0141), DNA primase (PFI0530c), isocitrate dehydrogenase (PF13_0242), merozoite surface protein-1 (PFI1475w), and merozoite surface protein-7 (PF13_0197). Results The results show that DB75 localizes in the parasite nucleus but not in other organelles. Once rings are exposed, parasites mature to the trophozoite stage and stall. No stage-dependent or gene-specific inhibition of transcription was seen. However, DB75 delayed peak transcription of trophozoite-stage genes. Conclusion Taken together, DB75 appears to concentrate in the nucleus and delay parasite maturation.
Influence of spin polarizability on liquid gas phase transition in the nuclear matter
Creators: name: Rezaei, Z.
name: Bigdeli, M.
name: Bordbar, G. H.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Nuclear Theory (nucl-th)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: In this paper, we investigate the liquid gas phase transition for the spin polarized nuclear matter. Applying the lowest order constrained variational (LOCV) method, and using two microscopic potentials, $AV_{18}$ and $UV_{14}$+TNI, we calculate the free energy, equation of state, order parameter, entropy, heat capacity and compressibility to derive the critical properties of spin polarized nuclear matter. Our results indicate that for the spin polarized nuclear matter, the second order phase transition takes place at lower temperatures with respect to the unpolarized one. It is also shown that the critical temperature of our spin polarized nuclear matter with a specific value of spin polarization parameter is in good agreement with the experimental result.
description: 26 pages, 13 figures, 4 tables
МЕТОД РАЗВИТИЕ СКОРОСТНЫХ СПОСОБНОСТЕЙ У ФУТБОЛИСТОВ 14-15 ЛЕТ
Creators: name: Н. Х. Умаров
Publisher: name: Central Asian Research Journal for Interdisciplinary Studies (CARJIS)
Year: 2022
Subjects: motor
premotor
motor reaction
from a high start
significant differences
speed abilities
моторная
премоторная
двигательная реакция
с высокого старта
достоверных различий
скоростные способности.

description: В статье рассмотрены вопросы развития скоростных способностей у футболистов 14-15 лет.
description: The article deals with the development of high-speed abilities of football players aged 14-15 years.
On the number of solutions of a quadratic equation in a normed space
Creators: name: Alexandrov, Victor
Publisher: name: arXiv
Year: 2015
Subjects: subject: Functional Analysis (math.FA)
subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 47H30, 39B52, 35Q60

description: We study an equation $Qu=g$, where $Q$ is a continuous quadratic operator acting from one normed space to another normed space. Obviously, if $u$ is a solution of such equation then $-u$ is also a solution. We find conditions implying that there are no other solutions and apply them to the study of the Dirichlet boundary value problem for the partial differential equation $uΔu =g$.
description: 6 pages
Data, Disorder in convergent floral nanostructures enhances signalling to bees
Creators: name: Wenzel, Tobias
name: Moyroud, Edwige
name: Vignolini, Silvia
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Coevolution
subject: Computer simulation
subject: Evolutionary ecology
subject: Materials science
subject: Nanoscale materials
subject: Optical materials and structures
subject: Optics and photonics
subject: Plant evolution
subject: Plant sciences

description: Data and material for the associated publication with the DOI: 10.1038/nature24285
Diabetes-specific genetic effects on obesity traits in American Indian populations: the Strong Heart Family Study
Creators: name: Franceschini, Nora
name: North, Kari
Publisher: name: BioMed Central Ltd
Year: 2008

description: Abstract Background Body fat mass distribution and deposition are determined by multiple environmental and genetic factors. Obesity is associated with insulin resistance, hyperinsulinemia, and type 2 diabetes. We previously identified evidence for genotype-by-diabetes interaction on obesity traits in Strong Heart Family Study (SHFS) participants. To localize these genetic effects, we conducted genome-wide linkage scans of obesity traits in individuals with and without type 2 diabetes, and in the combined sample while modeling interaction with diabetes using maximum likelihood methods (SOLAR 2.1.4). Methods SHFS recruited American Indians from Arizona, North and South Dakota, and Oklahoma. Anthropometric measures and diabetes status were obtained during a clinic visit. Marker allele frequencies were derived using maximum likelihood methods estimated from all individuals and multipoint identity by descent sharing was estimated using Loki. We used variance component linkage analysis to localize quantitative trait loci (QTLs) influencing obesity traits. We tested for evidence of additive and QTL-specific genotype-by-diabetes interactions using the regions identified in the diabetes-stratified analyses. Results Among 245 diabetic and 704 non-diabetic American Indian individuals, we detected significant additive gene-by-diabetes interaction for weight and BMI (P < 0.02). In analysis accounting for QTL-specific interaction (P < 0.001), we detected a QTL for weight on chromosome 1 at 242 cM (LOD = 3.7). This chromosome region harbors the adiponectin receptor 1 gene, which has been previously associated with obesity. Conclusion These results suggest distinct genetic effects on body mass in individuals with diabetes compared to those without diabetes, and a possible role for one or more genes on chromosome 1 in the pathogenesis of obesity.
Double copies of fermions as only gravitational interacting matter
Creators: name: de la Cruz, Leonardo
name: Kniss, Alexander
name: Weinzierl, Stefan
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Inspired by the recent progress in the field of scattering amplitudes, we discuss hypothetical particles which can be characterised as the double copies of fermions -- in the same way gravitons can be viewed as double copies of gauge bosons. As the gravitons, these hypothetical particles interact only through gravitational interactions. We present two equivalent methods for the computation of the relevant scattering amplitudes. The hypothetical particles can be massive and non-relativistic.
description: 5 pages, v2: version to be published
Tumor specific HMG-CoA reductase expression in primary pre-menopausal breast cancer predicts response to tamoxifen
Creators: name: Millikan, Robert C.
Publisher: name: BioMed Central Ltd
Year: 2011

description: Abstract Introduction We previously reported an association between tumor-specific 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMG-CoAR) expression and a good prognosis in breast cancer. Here, the predictive value of HMG-CoAR expression in relation to tamoxifen response was examined. Methods HMG-CoAR protein and RNA expression was analyzed in a cell line model of tamoxifen resistance using western blotting and PCR. HMG-CoAR mRNA expression was examined in 155 tamoxifen-treated breast tumors obtained from a previously published gene expression study (Cohort I). HMG-CoAR protein expression was examined in 422 stage II premenopausal breast cancer patients, who had previously participated in a randomized control trial comparing 2 years of tamoxifen with no systemic adjuvant treatment (Cohort II). Kaplan-Meier analysis and Cox proportional hazards modeling were used to estimate the risk of recurrence-free survival (RFS) and the effect of HMG-CoAR expression on tamoxifen response. Results HMG-CoAR protein and RNA expression were decreased in tamoxifen-resistant MCF7-LCC9 cells compared with their tamoxifen-sensitive parental cell line. HMG-CoAR mRNA expression was decreased in tumors that recurred following tamoxifen treatment (P < 0.001) and was an independent predictor of RFS in Cohort I (hazard ratio = 0.63, P = 0.009). In Cohort II, adjuvant tamoxifen increased RFS in HMG-CoAR-positive tumors (P = 0.008). Multivariate Cox regression analysis demonstrated that HMG-CoAR was an independent predictor of improved RFS in Cohort II (hazard ratio = 0.67, P = 0.010), and subset analysis revealed that this was maintained in estrogen receptor (ER)-positive patients (hazard ratio = 0.65, P = 0.029). Multivariate interaction analysis demonstrated a difference in tamoxifen efficacy relative to HMG-CoAR expression (P = 0.05). Analysis of tamoxifen response revealed that patients with ER-positive/HMG-CoAR tumors had a significant response to tamoxifen (P = 0.010) as well as patients with ER-positive or HMG-CoAR-positive tumors (P = 0.035). Stratification according to ER and HMG-CoAR status demonstrated that ER-positive/HMG-CoAR-positive tumors had an improved RFS compared with ER-positive/HMG-CoAR-negative tumors in the treatment arm (P = 0.033); this effect was lost in the control arm (P = 0.138), however, suggesting that HMG-CoAR predicts tamoxifen response. Conclusions HMG-CoAR expression is a predictor of response to tamoxifen in both ER-positive and ER-negative disease. Premenopausal patients with tumors that express ER or HMG-CoAR respond to adjuvant tamoxifen.
Light-like $κ$-deformations and scalar field theory via Drinfeld twist
Creators: name: Jurić, Tajron
name: Meljanac, Stjepan
name: Samsarov, Andjelo
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this article we will use the Drinfeld twist leading to light-like $κ$-deformations of Poincaré algebra. We shall apply the standard Hopf algebra methods in order to define the star-product, which shall be used to formulate a scalar field theory compatible with $κ$-Poincaré-Hopf algebra. Using this approach we show that there is no problem with formulating integration on $κ$-Minkowski space and no need for introducing a new measure. We have shown that the $\star$-product obtained from this twist enables us to define a free scalar field theory on $κ$-Minkowski space that is equivalent to a commutative one on a usual Minkowski space. We also discuss the interacting $ϕ^4$ scalar field model compatible with $κ$-Poincaré-Hopf algebra.
description: 11 pages, accepted for publication in the Proceedings of the NCG parallel session of the conference Conceptual and Technical Challenges in Quantum Gravity 2014 to be published in the Journal of Physics Conference Series
Striatal mechanisms for entrainment to high frequency components - an in silico study
Creators: name: Pajo, Kadri
name: Hjorth, Johannes
name: Frost Nylén, Johanna
name: Carannante, Ilaria
name: Kozlov, Alexander
name: Grillner, Sten
name: Hellgren Kotaleski, Jeanette
Publisher: name: Zenodo
Year: 2023

description: Poster presentation at SfN2022, San Diego, CA. Program No. 690.21.
Organic semiconductor photocatalyst can bifunctionalize arenes and heteroarenes
Creators: name: Ghosh, Indrajit
name: Khamrai, Jagadish
name: Savateev, Aleksandr
name: Shlapakov, Nikita
name: Antonietti, Markus
name: König, Burkhard
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: GRAPHITIC CARBON NITRIDE; C-H FUNCTIONALIZATION; CATALYZED ELECTROPHILIC AMINATION; PHOTOREDOX CATALYSIS; ARYL HALIDES; TRIFLUOROMETHYLATION; CYANATION; HYDROGEN; REDUCTION; LIGAND;
subject: 540 Chemie

description: Photoexcited electron-hole pairs on a semiconductor surface can engage in redox reactions with two different substrates. Similar to conventional electrosynthesis, the primary redox intermediates afford only separate oxidized and reduced products or, more rarely, combine to one addition product. Here, we report that a stable organic semiconductor material, mesoporous graphitic carbon nitride (mpg-CN), can act as a visible-light photoredox catalyst to orchestrate oxidative and reductive interfacial electron transfers to two different substrates in a two-or three-component system for direct twofold carbon-hydrogen functionalization of arenes and heteroarenes. The mpg-CN catalyst tolerates reactive radicals and strong nucleophiles, is straightforwardly recoverable by simple centrifugation of reaction mixtures, and is reusable for at least four catalytic transformations with conserved activity.
Characterizing the three-orbital Hubbard model with determinant quantum Monte Carlo
Creators: name: Kung, Y. F.
name: Chen, C. -C.
name: Wang, Yao
name: Huang, E. W.
name: Nowadnick, E. A.
name: Moritz, B.
name: Scalettar, R. T.
name: Johnston, S.
name: Devereaux, T. P.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We characterize the three-orbital Hubbard model using state-of-the-art determinant quantum Monte Carlo (DQMC) simulations with parameters relevant to the cuprate high-temperature superconductors. The simulations find that doped holes preferentially reside on oxygen orbitals and that the (π,π) antiferromagnetic ordering vector dominates in the vicinity of the undoped system, as known from experiments. The orbitally-resolved spectral functions agree well with photoemission spectroscopy studies and enable identification of orbital content in the bands. A comparison of DQMC results with exact diagonalization and cluster perturbation theory studies elucidates how these different numerical techniques complement one another to produce a more complete understanding of the model and the cuprates. Interestingly, our DQMC simulations predict a charge-transfer gap that is significantly smaller than the direct (optical) gap measured in experiment. Most likely, it corresponds to the indirect gap that has recently been suggested to be on the order of 0.8 eV, and demonstrates the subtlety in identifying charge gaps.
description: 16 pages, 18 figures
Parity-related molecular signatures and breast cancer subtypes by estrogen receptor status
Creators: name: Sun, Xuezheng
name: Yang, Xiaohong R
Publisher: name: BioMed Central Ltd
Year: 2014

description: Abstract Introduction Relationships of parity with breast cancer risk are complex. Parity is associated with decreased risk of postmenopausal hormone receptor–positive breast tumors, but may increase risk for basal-like breast cancers and early-onset tumors. Characterizing parity-related gene expression patterns in normal breast and breast tumor tissues may improve understanding of the biological mechanisms underlying this complex pattern of risk. Methods We developed a parity signature by analyzing microRNA microarray data from 130 reduction mammoplasty (RM) patients (54 nulliparous and 76 parous). This parity signature, together with published parity signatures, was evaluated in gene expression data from 150 paired tumors and adjacent benign breast tissues from the Polish Breast Cancer Study, both overall and by tumor estrogen receptor (ER) status. Results We identified 251 genes significantly upregulated by parity status in RM patients (parous versus nulliparous; false discovery rate = 0.008), including genes in immune, inflammation and wound response pathways. This parity signature was significantly enriched in normal and tumor tissues of parous breast cancer patients, specifically in ER-positive tumors. Conclusions Our data corroborate epidemiologic data, suggesting that the etiology and pathogenesis of breast cancers vary by ER status, which may have implications for developing prevention strategies for these tumors.
ОПТИМИЗАЦИЯ ПРОФИЛАКТИКИ БРОНХОЛЕГОЧНЫХ ЗАБОЛЕВАНИЙ У ЛИЦ МОЛОДОГО ВОЗРАСТА С УЧЕТОМ ФАКТОРА ТАБАКОКУРЕНИЯ
Creators: name: Хуршидбек Муслимович Ташметов
name: Наима Набихановна Убайдуллаева
Publisher: name: Central Asian Research Journal for Interdisciplinary Studies (CARJIS)
Year: 2022
Subjects: табакокурение
лица молодого возраста
тест Фагерстрема
окись углерода в выдыхаемом.

description: Одним из важнейших рисков развития БЛЗ является табакокурение, которое отличается высокой агрессивностью деструктивной детерминации среди факторов риска и приводящему к выраженной реструктивизации бронхолегочного аппарата с дисфункцией внешнего дыхания в целом. В данной статье отражены подходы к оптимизации профилактики БЛЗ среди лиц молодого возраста, в основе которого лежат определение уровня диагностической значимости вопросника, скрининговых тестов (тест Фагерстрема, определение уровня оксида углерода в выдыхаемом воздухе) в отношении степени выраженности обструктивных нарушений и др. параметров.
An examination of the effects of downsizing on organizational performance
Creators: name: Smith, Tashonna Lorraine
Publisher: name: No Publisher Supplied
Year: 2011

description: The purpose of this study is to develop greater understanding about how organizations can continuously adapt as their competitive landscapes continuously transform. Theories of organizational change emphasize episodic changes or slowtransformation, but many organizations now face continued turbulence as their technologies, markets, and competitors shift unpredictably. I investigate the relationship between continual product innovation and repeated episodes of downsizing, two primaryapproaches for adapting to turbulent conditions that are often employed simultaneously, since an organization must introduce streams of new products to stay current with evolving markets, while at the same time must cut costs to respond to intense competition. However, downsizing and product innovation may be negatively correlated, which would create a significant tension in managing organizational adaptation. This research seeks to develop better theory for managing continual organizational adaptation by exploring how these potentially conflicting means for adaptation interact. Through product innovation, organizations can continuously adapt to turbulent conditions by strengthening their position with product enhancements, and exploiting capabilities. To be capable of ongoing product innovation, organizations must maintain employee skills and capabilities for creating, combining, and recombining knowledge, and working collaboratively in multifunctional networks. Downsizing may disrupt both employee capabilities and the strategic commitment necessary for product innovation. Research is unclear: while several studies suggest that downsizing reduces innovativeness, no study has specifically examined the actual effects of repeated downsizing on product innovation over time and the connections between these practicesand ongoing innovation remains unexplained. To sort out these divergent ideas about downsizing and innovation, I use data from a panel of 2174 product innovations that were initiated during a 39 month period at one telecommunications firm when the firm carried out downsizing events. This study found that the general effect of downsizing increases the likelihood of projectwithdrawal. Convergence protects radical innovations and buffers them from withdrawal; no effect on completion. Reorientation enhances the likelihood of starting new projects and this prospect increases for more radical product categories. Overall, ittakes time for managers to get up to speed with the strategic implications of downsizing and resources are wasted, a potential pitfall for innovation.
lsis im Osten
Creators: name: Vaelske, Veit
Publisher: name: Humboldt-Universität zu Berlin
Year: 2018
Subjects: subject: Ägypten
subject: Levante
subject: Religion
subject: Hellenismus
subject: Römische Kaiserzeit
subject: Palästina
subject: Phönizien
subject: Syrien
subject: Jordanien
subject: Isis
subject: Sarapis
subject: Petra
subject: Nabatäer
subject: Archäologie
subject: Antike
subject: Egypt
subject: Orient
subject: Isis-religion
subject: Graeco-Roman
subject: 930 Geschichte des Altertums bis ca. 499, Archäologie
subject: LE 5820

description: Die im Oktober 2011 verteidigte und mit der Note "summa cum laude" bewertete Arbeit beschäftigt sich mit der Auswertung aller bis 2011 bekannt gewordener Zeugnisse, die im Nahen Osten auf eine Kenntnisnahme und Verehrung der ägyptischen Götter Isis, Sarapis, Apis, Harpokrates etc. hindeuten. Eine grundlegende Materialaufnahme mithilfe eines DAAD-Stipendiums erfolgte 2003 bis 2004 in allen Levanteländern. Die im Zuge dieser Recherchen allerdings ausufernde Materialbasis führte dazu, den Fokus der Dissertation auf die südliche Levante zu richten. Zeitlich wurden vor allem die Jahrhunderte der hellenistischen und römischen Beherrschung des Gebiets näher untersucht.
description: This thesis, defended in October 2011 and rated "summa cum laude", evaluates testimonies that became known until 2011, which in the Middle East point to a recognition and worship of the Egyptian gods Isis, Sarapis, Apis, Harpocrates, etc. , Basic material was collected with the help of a DAAD scholarship in 2003-2004 in all Levant countries. However, in the course of these researches, a sprawling material base led to the focus of the dissertation on the southern Levant. In particular, the centuries of Hellenistic and Roman domination of the area were examined more closely.
A compact VEGF signature associated with distant metastases and poor outcomes
Creators: name: Perou, Charles
name: Oh, Daniel S.
name: Livasy, Chad
name: Carey, Lisa
name: Hu, Zhiyuan
name: He, Xiaping
name: Ewend, Matthew G.
name: Fan, Cheng
Publisher: name: BioMed Central Ltd
Year: 2009

description: Abstract: Background: Tumor metastases pose the greatest threat to a patient's survival, and thus, understanding the biology of disseminated cancer cells is critical for developing effective therapies. Methods: Microarrays and immunohistochemistry were used to analyze primary breast tumors, regional (lymph node) metastases, and distant metastases in order to identify biological features associated with distant metastases. Results: When compared with each other, primary tumors and regional metastases showed statistically indistinguishable gene expression patterns. Supervised analyses comparing patients with distant metastases versus primary tumors or regional metastases showed that the distant metastases were distinct and distinguished by the lack of expression of fibroblast/mesenchymal genes, and by the high expression of a 13-gene profile (that is, the 'vascular endothelial growth factor (VEGF) profile') that included VEGF, ANGPTL4, ADM and the monocarboxylic acid transporter SLC16A3. At least 8 out of 13 of these genes contained HIF1α binding sites, many are known to be HIF1α-regulated, and expression of the VEGF profile correlated with HIF1α IHC positivity. The VEGF profile also showed prognostic significance on tests of sets of patients with breast and lung cancer and glioblastomas, and was an independent predictor of outcomes in primary breast cancers when tested in models that contained other prognostic gene expression profiles and clinical variables. Conclusion: These data identify a compact in vivo hypoxia signature that tends to be present in distant metastasis samples, and which portends a poor outcome in multiple tumor types. This signature suggests that the response to hypoxia includes the ability to promote new blood and lymphatic vessel formation, and that the dual targeting of multiple cell types and pathways will be needed to prevent metastatic spread.
ПАТОГЕНЕТИЧЕСКАЯ СВЯЗЬ БИОМАРКЕРОВ ИММУННОГО ОТВЕТА В ПРОГНОЗЕ ПРОГРЕССИРОВАНИЯ ХОБЛ
Creators: name: Гулчехра Талиповна Ташметова
Publisher: name: Central Asian Research Journal for Interdisciplinary Studies (CARJIS)
Year: 2022
Subjects: фенотипы ХОБЛ
местный и ситемный иммунитет
иммунобиологические маркеры

description: Корреляционные взаимосвязи, уровни соотношения биомаркеров местного, так и системного иммунного ответа определяют формирование иммуного ответа при ХОБЛ. Нарушение баланса цитокинового профиля у больных ХОБЛ с тяжелым течением заболевания и эмфизематозным фенотипом имеет выраженную некомпенсированную провоспалительную направленность и приводит к формированию аутоиммунных нарушений с характерным повышением уровня антител к легочной ткани.
Training health care workers to promote HIV services for patients with tuberculosis in the Democratic Republic of Congo
Creators: name: Sabue, Mulangu
name: Driessche, Koen
name: Behets, Frieda
name: Van Rie, Annelies
name: Dufour, Wendy
Publisher: name: BioMed Central Ltd
Year: 2009

description: Abstract Background HIV counseling and testing, HIV prevention and provision of HIV care and support are essential activities to reduce the burden of HIV among patients with TB, and should be integrated into routine TB care. Methods The development of training materials to promote HIV services for TB patients involved the definition of target health care workers (HCWs); identification of required tasks, skills and knowledge; review of international guidelines; and adaptation of existing training materials for voluntary counseling and testing, prevention of mother-to-child transmission of HIV, and management of opportunistic infections (OIs). Training effectiveness was assessed by means of questionnaires administered pre- and post-training, by correlating post-training results of HCWs with the centre's HIV testing acceptance rates, and through participatory observations at the time of on-site supervisory visits and monthly meetings. Results Pre-training assessment identified gaps in basic knowledge of HIV epidemiology, the link between TB and HIV, interpretation of CD4 counts, prevention and management of OIs, and occupational post-exposure prophylaxis (PEP). Opinions on patients' rights and confidentiality varied. Mean test results increased from 72% pre-training to 87% post-training (p < 0.001). Important issues regarding HIV epidemiology and PEP remained poorly understood post-training. Mean post-training scores of clinic's HCWs were significantly correlated with the centre's HIV testing acceptance rates (p = 0.01). On-site supervisory visits and monthly meetings promoted staff motivation, participatory problem solving and continuing education. Training was also used as an opportunity to improve patient-centred care and HCWs' communication skills. Conclusion Many HCWs did not possess the knowledge or skills necessary to integrate HIV activities into routine care for patients with TB. A participatory approach resulted in training materials that fulfilled local needs.
Controllable Isomerization of Alkenes by Dual Visible-Light-Cobalt Catalysis
Creators: name: Meng, Qing-Yuan
name: Schirmer, Tobias
name: Katou, Kousuke
name: König, Burkhard
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: THERMAL-DECOMPOSITION; TERMINAL ALKENES; BITE ANGLE; 1-ALKENES; HYDROGEN; MONOISOMERIZATION; DEBROMINATION; COMPLEXES; MECHANISM; EFFICIENT; alkene isomerization; cobalt; photosynthesis; visible light catalysis
subject: 540 Chemie

description: We report herein that thermodynamic and kinetic isomerization of alkenes can be accomplished by the combination of visible light with Co catalysis. Utilizing Xantphos as the ligand, the most stable isomers are obtained, while isomerizing terminal alkenes over one position can be selectively controlled by using DPEphos as the ligand. The presence of the donor-acceptor dye 4CzIPN accelerates the reaction further. Transformation of exocyclic alkenes into the corresponding endocyclic products could be efficiently realized by using 4CzIPN and Co(acac)(2) in the absence of any additional ligands. Spectroscopic and spectroelectrochemical investigations indicate CoI being involved in the generation of a Co hydride, which subsequently adds to alkenes initiating the isomerization.
Explicit construction of single input - single output logic gates from three soliton solution of Manakov system
Creators: name: Vijayajayanthi, M.
name: Kanna, T.
name: Lakshmanan, M.
name: Murali, K.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: Pattern Formation and Solitons (nlin.PS)
subject: FOS: Physical sciences

description: We construct single input logic gates using the energy sharing collisions of a minimal number of (three) bright optical solitons associated with the three soliton solution of the integrable Manakov system. As computation requires state changes to represent binary logic, here we make use of the state change of a particular soliton during its sequential collision with other two solitons for constructing single input gates. As a consequence, we clearly demonstrate the construction of various one-input logic gates such as COPY gate, NOT gate and ONE gate using energy sharing three soliton collision of Manakov system. This type of realization of logic gates just from a three soliton collision (pair-wise interaction) is clearly distinct from the earlier studies which require separate collisions of four solitons.
description: 22 pages, 7 figures
Attitudes of dermatologists in the southeastern United States regarding treatment of alopecia areata: a cross-sectional survey study.
Creators: name: Stewart, Paul
name: Mukherjee, Niyati
name: Morrell, Dean S
name: Goldsmith, Lowell A
Publisher: name: BioMed Central Ltd
Year: 2009

description: Abstract Background Little evidence exists to guide treatment of alopecia areata (AA). The current practices in treatment of children compared to adults and of progressive stages of hair loss are unknown. The objective of this study was to examine the current practices of southeastern United States dermatologists for the treatment of AA. Methods Dermatologists were sent anonymous questionnaires regarding their treatment practices by mail. Respondents' frequencies of treatment in children compared to adults and in patchy hair loss compared to widespread hair loss were compared with Wilcoxon signed-ranks tests and Friedman tests. As a secondary source, the National Alopecia Areata Registry (NAAR) database was analyzed for patients' treatment histories. Results Survey results suggested that dermatologists recommend treatment less frequently for children than adults and for more advanced hair loss. NAAR data confirmed that offering no treatment for AA is relatively common. Conclusion Dermatologists' treatment of AA is inconsistent. A stronger evidence base will provide more consistent treatment options.
The bounce universe history from unimodular $F(R)$ gravity
Creators: name: Nojiri, S.
name: Odintsov, S. D.
name: Oikonomou, V. K.
Publisher: name: arXiv
Year: 2016
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: In this paper we investigate how to realize various quite well known cosmological bouncing models in the context of the recently developed unimodular $F(R)$ gravity. Particularly, we shall study the matter bounce scenario, the singular bounce, the superbounce and a symmetric bounce scenario. We present the behavior of the Hubble radius for each of the bouncing models we shall take into account and we investigate which era of the bouncing model is responsible for the cosmological perturbations. As we shall demonstrate, the various bouncing models do not behave in the same way, so the cosmological perturbations for each model may correspond to a different era, in comparison to other models. Also we present which unimodular $F(R)$ gravity realizes each model. We also show that Newton's law is not modified in the unimodular $F(R)$ gravity, which also is proven to be a ghost-free theory, and in addition we discuss the matter stability issue. Finally, we demonstrate how it is possible to solve a cosmological constant problem in the context of unimodular $F(R)$ gravity.
description: PRD version
Photocarboxylation of Benzylic C-H bonds
Creators: name: Meng, Qing-Yuan
name: Schirmer, Tobias
name: Berger, Anna Lucia
name: Donabauer, Karsten
name: König, Burkhard
Publisher: name: Universität Regensburg
Year: 2019
Subjects: subject: CARBON-DIOXIDE; VISIBLE-LIGHT; CATALYZED CARBOXYLATION; REDUCTION POTENTIALS; ALKENES; CO2; CARBONYLATION; RADICALS; HALIDES; SYSTEM;
subject: 540 Chemie

description: The carboxylation of sp(3)-hybridized C-H bonds with CO2 is a challenging transformation. Herein, we report a visible-light-mediated carboxylation of benzylic C-H bonds with CO2 into 2-arylpropionic acids under metal-free conditions. Photo-oxidized triisopropylsilanethiol was used as the hydrogen atom transfer catalyst to afford a benzylic radical that accepts an electron from the reduced form of 2,3,4,6-tetra(9H-carbazol-9-yl)-5-(1-phenylethyl)benzonitrile generated in situ. The resulting benzylic carbanion reacts with CO2 to generate the corresponding carboxylic acid after protonation. The reaction proceeded without the addition of any sacrificial electron donor, electron acceptor or stoichiometric additives. Moderate to good yields of the desired products were obtained in a broad substrate scope. Several drugs were successfully synthesized using the novel strategy.
ПОВЫШЕНИЕ ЭФФЕКТИВНОСТИ ПРОЦЕССА СОВЕРШЕНСТВОВАНИЯ КОНДИЦИОННЫХ КАЧЕСТВ ЮНЫХ ВОЛЕЙБОЛИСТОВ
Creators: name: А. Ю. Частоедова
name: Э. Р. Мурадасилова
name: М. Р. Израильбекова
name: Х. С. Арабов
Publisher: name: Central Asian Research Journal for Interdisciplinary Studies (CARJIS)
Year: 2022
Subjects: волейболисты
начальный этап подготовки
кондиционные качества
физическая подготовленность
двигательная деятельность
методика подготовки.
volleyball players
initial stage of training
conditioning quality
physical fitness
motor activity
preparation technique.

description: B статье рассматриваются современные подходы в воспитании кондиционных качеств юных волейболистов с использованием нетрадиционных подходов
description: The article discusses modern approaches to the upbringing of conditioned qualities of young volleyball players using non-traditional approaches
A quantitative measure of restricted and repetitive behaviors for early childhood
Creators: name: Boyd, Brian
Publisher: name: BioMed Central
Year: 2016

description: Abstract Background Restricted and repetitive behaviors are characteristic phenotypic features of many neurodevelopmental, psychiatric, and neurological conditions. During early childhood, such behaviors are considered normative. More research is needed to delineate the dimensions of restricted and repetitive behavior across typical and atypical development during this period. Methods We developed the 34-item parent-rated Repetitive Behavior Scale for Early Childhood (RBS-EC) to capture quantitative, dimensional features across a broad range of behaviors contributing to this domain. We evaluated its psychometric properties and factor structure in a community sample of 914 toddlers. Results The RBS-EC showed excellent overall internal consistency (α = 0.90), strong test-retest reliability (ICC = 0.87 for topographies and 0.90 for frequency) and evidence of convergent and discriminative validity. Using a split-half approach to factor analysis, we identified that a three- or four-factor structure best fit the data and confirmatory factor analysis indicated acceptable fit for both models. The empirically derived four-factor model was consistent with our conceptual model and included repetitive motor, restricted interests and behavior, ritual and routine, and self-directed behavior. Conclusions This initial study indicates that the RBS-EC is a reliable and valid instrument for characterizing quantitative, dimensional aspects of restricted and repetitive behaviors in young children.
Naturalization Records of Petitioner Charles Betzner
Creators: name: United States. Bureau Of Naturalization
Publisher: name: No Publisher Supplied
Year: 1897

description: Naturalization records to become a citizen of the United States, as filled out and signed by: Charles Betzner Country of origin: Germany Age of petitioner: Unknown Occupation: Unknown City of residence at time of declaration: Unknown Date petition filed: 14 January 1897 Name of witness: George Hauselmann
FLE revisited: role of objective comprehension
Creators: name: Liu, Chuanjun
Publisher: name: Open Science Framework
Year: 2022
Subjects: subject: Multicultural Psychology
subject: Social Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology
subject: CAN algorithm
subject: CNI model
subject: comprehension
subject: Foreign language effect
subject: moral decision
subject: process dissociation
subject: understanding

description: Previous research has indicated that, compared to the native language, reading the moral dilemma scenarios presented in a foreign language makes people more willing to conduct harmful action to save more people. However, we cannot exclude the possibility that the foreign (vs. native) language makes people less comprehend the materials, which further affects their moral decisions. To address this alternative explanation, we plan to re-analyze the raw data of a previous FLE study (Białek et al., 2019).
Declaration of Intention of Hedwig Gentsch
Creators: name: United States. Bureau Of Naturalization
Publisher: name: No Publisher Supplied
Year: 1920

description: Declaration of Intention to become a citizen of the United States, as filled out and signed by: Hedwig Gentsch Applicant age:56Occupation: MaidCountry of Origin:GermanyDate of Birth: 25 June 1864Sailed to the US aboard the vessel: Unknown City of residence at time of declaration: Atlantic City NJDeclaration submitted and sworn on date:8 September 1920