title: ÐÐ·Ð¼ÐµÐ½ÐµÐ½Ð¸Ðµ Ð»Ð¸Ð¿Ð¸Ð´Ð½Ð¾Ð³Ð¾ Ð±Ð¸Ð¾Ð³ÐµÐ½ÐµÐ·Ð° Ð¿ÑÐ¸ Ð¾ÑÐ»Ð¾Ð¶ÐµÐ½Ð¸Ð¸ Ð°Ð¼Ð¸Ð»Ð¾Ð¸Ð´Ð½Ð¾Ð³Ð¾ Ð¿ÐµÐ¿ÑÐ¸Ð´Ð° Ð±ÐµÑÐ° Ð² Ð½ÐµÑÐ²Ð½Ð¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ðµ Drosophila melanogaster
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Changes in lipid biogenesis during deposition of amyloid beta peptide in the nervous system of Drosophila melanogaster
Creators: name: Ð§Ð°Ð¹ÐºÐ¾Ð²ÑÐºÐ°Ñ, ÐÐ²Ð³ÐµÐ½Ð¸Ñ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: Ð±Ð¾Ð»ÐµÐ·Ð½Ñ ÐÐ»ÑÑÐ³ÐµÐ¹Ð¼ÐµÑÐ°
Ð±ÐµÐ»Ð¾Ðº Ð¿ÑÐµÐ´ÑÐµÑÑÐ²ÐµÐ½Ð½Ð¸Ðº Ð°Ð¼Ð¸Ð»Ð¾Ð¸Ð´Ð°
Ð°Ð¼Ð¸Ð»Ð¾Ð´Ð½ÑÐ¹ Ð¿ÐµÐ¿ÑÐ¸Ð´ Ð±ÐµÑÐ°
drosophila melanogaster
Alzheimer's disease
amiloid precurcor protein
amyloid peptide beta
lipid dropletsÑÑ

description: Ð¢ÐµÐ¼Ð° Ð²ÑÐ¿ÑÑÐºÐ½Ð¾Ð¹ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ: Â«ÐÐ·Ð¼ÐµÐ½ÐµÐ½Ð¸Ðµ Ð»Ð¸Ð¿Ð¸Ð´Ð½Ð¾Ð³Ð¾ Ð±Ð¸Ð¾Ð³ÐµÐ½ÐµÐ·Ð° Ð¿ÑÐ¸ Ð¾ÑÐ»Ð¾Ð¶ÐµÐ½Ð¸Ð¸ Ð°Ð¼Ð¸Ð»Ð¾Ð¸Ð´Ð½Ð¾Ð³Ð¾ Ð¿ÐµÐ¿ÑÐ¸Ð´Ð° Ð±ÐµÑÐ° Ð² Ð½ÐµÑÐ²Ð½Ð¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ðµ Drosophila melanogasterÂ». ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ ÑÐ°ÑÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ñ Ð½ÐµÐ¹ÑÑÐ°Ð»ÑÐ½ÑÑ Ð»Ð¸Ð¿Ð¸Ð´Ð¾Ð² Ð² Ð¼Ð¾Ð·Ð³Ðµ Drosophila melanogaster Ð¿ÑÐ¸ Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ð¸ Ð±Ð¾Ð»ÐµÐ·Ð½Ð¸ ÐÐ»ÑÑÐ³ÐµÐ¹Ð¼ÐµÑÐ°, Ð° ÑÐ°ÐºÐ¶Ðµ Ð°Ð½Ð°Ð»Ð¸Ð·Ñ ÐºÐ¾Ð»Ð¸ÑÐµÑÑÐ²Ð° Ð¸ ÑÐ°ÑÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ñ Ð»Ð¸Ð¿Ð¸Ð´Ð½ÑÑ ÐºÐ°Ð¿ÐµÐ»Ñ Ð² Ð¼Ð¾Ð·Ð³Ðµ Ð´ÑÐ¾Ð·Ð¾ÑÐ¸Ð»Ñ. ÐÐ°Ð´Ð°ÑÐ¸, ÐºÐ¾ÑÐ¾ÑÑÐµ Ð±ÑÐ»Ð¸ Ð¿Ð¾ÑÑÐ°Ð²Ð»ÐµÐ½Ñ Ð² ÑÐ¾Ð´Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ: ÐÑÑÐµÐ¼ ÑÐºÑÐµÑÐ¸Ð²Ð°Ð½Ð¸Ð¹ ÑÐ¸Ð½ÑÐµÐ·Ð¸ÑÐ¾Ð²Ð°ÑÑ ÑÑÐ°Ð½ÑÐ³ÐµÐ½Ð½ÑÐµ Ð³Ð¸Ð±ÑÐ¸Ð´Ñ Drosophila melanogaster, Ð²Ð¾ÑÐ¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ¸Ðµ Ð¿ÑÐ¸Ð·Ð½Ð°ÐºÐ¸ Ð±Ð¾Ð»ÐµÐ·Ð½Ð¸ ÐÐ»ÑÑÐ³ÐµÐ¹Ð¼ÐµÑÐ°. Ð£Ð´Ð¾ÑÑÐ¾Ð²ÐµÑÐ¸ÑÑÑÑ, ÑÑÐ¾ ÑÐ¸Ð½ÑÐµÐ·Ð¸ÑÐ¾Ð²Ð°Ð½Ð½ÑÐµ Ð³Ð¸Ð±ÑÐ¸Ð´Ñ Ð½Ð°ÐºÐ°Ð¿Ð»Ð¸Ð²Ð°ÑÑ Ð°Ð¼Ð¸Ð»Ð¾Ð¸Ð´Ð½ÑÐ¹ Ð¿ÐµÐ¿ÑÐ¸Ð´ Ð±ÐµÑÐ° Ð² Ð¼Ð¾Ð·Ð³Ðµ. ÐÑÐ¾Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°ÑÑ ÑÐ°ÑÐ¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð¸Ðµ Ð½ÐµÐ¹ÑÑÐ°Ð»ÑÐ½ÑÑ Ð»Ð¸Ð¿Ð¸Ð´Ð¾Ð² Ð² Ð¼Ð¾Ð·Ð³Ðµ ÑÐ¾Ð·Ð´Ð°Ð½Ð½ÑÑ Ð³Ð¸Ð±ÑÐ¸Ð´Ð¾Ð² ÑÐ°Ð·Ð½Ð¾Ð³Ð¾ Ð²Ð¾Ð·ÑÐ°ÑÑÐ°. ÐÑÐµÐ½Ð¸ÑÑ ÐºÐ¾Ð»Ð¸ÑÐµÑÑÐ²Ð¾ Ð»Ð¸Ð¿Ð¸Ð´Ð½ÑÑ ÐºÐ°Ð¿ÐµÐ»Ñ Ð² Ð½ÐµÐ¹ÑÐ¾Ð½Ð°Ñ Ð¸ Ð³Ð»Ð¸Ð¸ Ð¼Ð¾Ð·Ð³Ð° ÑÐ¾Ð·Ð´Ð°Ð½Ð½ÑÑ Ð³Ð¸Ð±ÑÐ¸Ð´Ð¾Ð² ÑÐ°Ð·Ð½Ð¾Ð³Ð¾ Ð²Ð¾Ð·ÑÐ°ÑÑÐ°. Ð Ð°Ð±Ð¾ÑÐ° Ð±ÑÐ»Ð° Ð¿ÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð° Ð½Ð° Ð±Ð°Ð·ÐµÂ  Ð¤ÐµÐ´ÐµÑÐ°Ð»ÑÐ½Ð¾Ð³Ð¾Â  Ð³Ð¾ÑÑÐ´Ð°ÑÑÑÐ²ÐµÐ½Ð½Ð¾Ð³Ð¾ Ð±ÑÐ´Ð¶ÐµÑÐ½Ð¾Ð³Ð¾ ÑÑÑÐµÐ¶Ð´ÐµÐ½Ð¸Ñ Â«ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¸Ð½ÑÑÐ¸ÑÑÑ ÑÐ´ÐµÑÐ½Ð¾Ð¹ ÑÐ¸Ð·Ð¸ÐºÐ¸ Ð¸Ð¼. Ð.Ð. ÐÐ¾Ð½ÑÑÐ°Ð½ÑÐ¸Ð½Ð¾Ð²Ð° ÐÐ°ÑÐ¸Ð¾Ð½Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°ÑÐµÐ»ÑÑÐºÐ¾Ð³Ð¾ ÑÐµÐ½ÑÑÐ° Â«ÐÑÑÑÐ°ÑÐ¾Ð²ÑÐºÐ¸Ð¹ Ð¸Ð½ÑÑÐ¸ÑÑÑÂ» Ð² Ð»Ð°Ð±Ð¾ÑÐ°ÑÐ¾ÑÐ¸Ð¸ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½Ð¾Ð¹ Ð¸Â  Ð¿ÑÐ¸ÐºÐ»Ð°Ð´Ð½Ð¾Ð¹Â  Ð³ÐµÐ½ÐµÑÐ¸ÐºÐ¸Â  Ð¿Ð¾Ð´ ÑÑÐºÐ¾Ð²Ð¾Ð´ÑÑÐ²Ð¾Ð¼ Ð´Ð¾ÐºÑÐ¾ÑÐ° Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ Ð½Ð°ÑÐºÂ  Ð¡Ð²ÐµÑÐ»Ð°Ð½ÑÂ  ÐÐ»Ð°Ð´Ð¸Ð¼Ð¸ÑÐ¾Ð²Ð½Ñ Ð¡Ð°ÑÐ°Ð½ÑÐµÐ²Ð¾Ð¹.Â 
description: Theme ofÂ  finalÂ  qualificationÂ  work: Â«Changes in lipid biogenesis during deposition of amyloid beta peptide in the nervous system of Drosophila melanogasterÂ». This work is devoted to the research of the distribution of neutral lipids in the brain of Drosophila melanogaster when modeling Alzheimer's disease, as well as the analysis of the quantity and distribution of lipid droplets in the brain of Drosophila.The tasks that were set during the study: To synthesize transgenic hybrids of Drosophila melanogaster reproducing signs of Alzheimer's disease by crossing. To ensure that the synthesized hybrids accumulate amyloid beta peptide in the brain. To analyze the distribution of neutral lipids in the brains of obtained hybrids of different ages. To estimate the number of lipid droplets in the neurons and glia of the brain of created hybrids of different ages. TheÂ  workÂ  wasÂ  carriedÂ  outÂ  atÂ  theÂ  FederalÂ  StateÂ  BudgetaryInstitution Petersburg Institute of Nuclear Physics named after B.P. KonstantinovNational Research Center Â«Kurchatov InstituteÂ» in the laboratory of experimentaland applied genetics under the supervision of Doctor of Biological Sciences Svetlana Vladimirovna Sarantseva.Â