cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Kepler-11 is a Solar Twin: Revising the Masses and Radii of Benchmark Planets Via Precise Stellar Characterization
Creators: name: Bedell, Megan
name: Bean, Jacob L.
name: Melendez, Jorge
name: Mills, Sean M.
name: Fabrycky, Daniel C.
name: Freitas, Fabricio C.
name: Ramirez, Ivan
name: Asplund, Martin
name: Liu, Fan
name: Yong, David
Publisher: name: arXiv
Year: 2016
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The six planets of the Kepler-11 system are the archetypal example of a population of surprisingly low-density transiting planets revealed by the Kepler mission. We have determined the fundamental parameters and chemical composition of the Kepler-11 host star to unprecedented precision using an extremely high quality spectrum from Keck-HIRES (R$\simeq$67,000, S/N per pixel$\simeq$260 at 600 nm). Contrary to previously published results, our spectroscopic constraints indicate that Kepler-11 is a young main-sequence solar twin. The revised stellar parameters and new analysis raise the densities of the Kepler-11 planets by between 20-95% per planet, making them more typical of the emerging class of "puffy" close-in exoplanets. We obtain photospheric abundances of 22 elements and find that Kepler-11 has an abundance pattern similar to that of the Sun with a slightly higher overall metallicity. We additionally analyze the Kepler lightcurves using a photodynamical model and discuss the tension between spectroscopic and transit/TTV-based stellar density estimates.
description: 15 pages, 7 figures; ApJ accepted version
Global unique solutions for the inhomogeneous Navier-Stokes equation with only bounded density, in critical regularity spaces
Creators: name: Danchin, Raphaël
name: Wang, Shan
Publisher: name: arXiv
Year: 2022
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: We here aim at proving the global existence and uniqueness of solutions to the inhomogeneous incompressible Navier-Stokes system in the case where the initial density is discontinuous and the initial velocity has critical regularity. Assuming that the initial density is close to a positive constant, we obtain global existence and uniqueness in the two-dimensional case whenever the initial velocity belongs to some critical homogeneous Besov space (and in small in the three-dimensional case). Next, still in a critical functional framework, we establish a uniqueness statement that is valid in the case of large variations of density with, possibly, vacuum. Interestingly, our result implies that the Fujita-Kato type solutions constructed by P. Zhang in are unique. Our work relies on interpolation results, time weighted estimates and maximal regularity estimates in Lorentz spaces (with respect to the time variable) for the evolutionary Stokes system.
Low-Redshift Lyman Limit Systems as Diagnostics of Cosmological Inflows and Outflows
Creators: name: Hafen, Z.
name: Faucher-Giguere, C. -A.
name: Angles-Alcazar, D.
name: Keres, D.
name: Feldmann, R.
name: Chan, T. K.
name: Quataert, E.
name: Murray, N.
name: Hopkins, P. F.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We use cosmological hydrodynamic simulations with stellar feedback from the FIRE project to study the physical nature of Lyman limit systems (LLSs) at z<1. At these low redshifts, LLSs are closely associated with dense gas structures surrounding galaxies, such as galactic winds, dwarf satellites, and cool inflows from the intergalactic medium. Our analysis is based on 14 zoom-in simulations covering the halo mass range M_h~10^9-10^13 Msun at z=0, which we convolve with the dark matter halo mass function to produce cosmological statistics. We find that the majority of cosmologically-selected LLSs are associated with halos in the mass range 10^10 < M_h < 10^12 Msun. The incidence and HI column density distribution of simulated absorbers with columns 10^16.2 < N_HI < 2x10^20 cm^-2 are consistent with observations. High-velocity outflows (with radial velocity exceeding the halo circular velocity by a factor >~2) tend to have higher metallicities ([X/H] ~ -0.5) while very low metallicity ([X/H] < -2) LLSs are typically associated with gas infalling from the intergalactic medium. However, most LLSs occupy an intermediate region in metallicity-radial velocity space, for which there is no clear trend between metallicity and radial kinematics. Metal-enriched inflows arise in the FIRE simulations as a result of galactic winds that fall back onto galaxies at low redshift. The overall simulated LLS metallicity distribution has a mean (standard deviation) [X/H] = -0.9 (0.4) and does not show significant evidence for bimodality, in contrast to recent observational studies but consistent with LLSs arising from halos with a broad range of masses and metallicities.
description: 13 pages, 12 figures. Accepted to MNRAS
title: EGFL7 as a tool to treat malignant glioma
Creators: name: Schmidt, Mirko
name: Dudvarski Stankovic, Nevenka
Publisher: name: German Medical Science GMS Publishing House
Year: 2015
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: Patients with malignant brain tumors have a poor prognosis of survival. The most lethal form, glioblastoma multiforme (GBM), is still non-curable despite of multimodal treatments. Patients havea median survival time of less than a year. Therefore new additional treatments are desirable.[for full text, please go to the a.m. URL]
description: 60th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN)
Motion of Satellite under the Effect of Oblateness of Earth and Atmospheric Drag
Creators: name: Sharma, Jaita
name: Ratanpal, B. S.
name: Pirzada, U. M.
name: Shah, Vishant
Publisher: name: arXiv
Year: 2016
Subjects: subject: Space Physics (physics.space-ph)
subject: FOS: Physical sciences

description: The equations governing motion of the satellite under the effect of oblateness of Earth and atmospheric drag have been simulated, for a fixed initial position and three different initial velocities, till satellite collapses on Earth. Simulation of motion of artificial Earth satellite subject to the combined effects of oblate Earth and atmospheric drag is presented. The atmospheric model considered here takes in to account of exponential variation of the density with initial distance of Satellite from Earth's surface, scale height and radial distance. The minimum and maximum values of orbital elements and their variation over a time for different initial velocities have been reported.
description: 21 figures, 3 tables
Optimising Antimicrobial Therapy in Renal Impairment
Creators: name: KATRINA WAI YUN HUI
Publisher: name: Monash University
Year: 2018
Subjects: subject: 110312 Nephrology and Urology
subject: FOS: Clinical medicine
subject: 111503 Clinical Pharmacy and Pharmacy Practice
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: This thesis investigates the use of antibiotics in people who have kidney failure and are receiving haemodialysis. This thesis identifies common antibiotics prescribed and aspects of antibiotic prescribing, such as dose and dosing frequency selection, which could be improved in this patient population. Appropriate dosage regimens for vancomycin and amoxycillin/clavulanic acid for patients receiving haemodialysis were also developed through the use of computer-based modelling and simulation. These findings can be used to guide the use and dosing of antibiotics in people receiving haemodialysis in order to improve patient outcomes.
A positivity preserving strategy for entropy stable discontinuous Galerkin discretizations of the compressible Euler and Navier-Stokes equations
Creators: name: Lin, Yimin
name: Chan, Jesse
name: Tomas, Ignacio
Publisher: name: arXiv
Year: 2022
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: High-order entropy-stable discontinuous Galerkin methods for the compressible Euler and Navier-Stokes equations require the positivity of thermodynamic quantities in order to guarantee their well-posedness. In this work, we introduce a positivity limiting strategy for entropy-stable discontinuous Galerkin discretizations constructed by blending high order solutions with a low order positivity-preserving discretization. The proposed low order discretization is semi-discretely entropy stable, and the proposed limiting strategy is positivity preserving for the compressible Euler and Navier-Stokes equations. Numerical experiments confirm the high order accuracy and robustness of the proposed strategy.
Effects of oxytocin in the ovis aries lung
Creators: name: JIBRIIL PATRICK IBRAHIM
Publisher: name: Monash University
Year: 2018
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: 111504 Pharmaceutical Sciences
subject: FOS: Clinical medicine

description: This thesis examined the effects of oxytocin in the lungs of sheep to determine whether an inhalable formulation of oxytocin could be used as an alternative delivery route for the management of uncontrollable bleeding after labour, without dangerous respiratory side effects.
On panel-regular ~A_2 lattices
Creators: name: Witzel, Stefan
Publisher: name: arXiv
Year: 2016
Subjects: subject: Group Theory (math.GR)
subject: FOS: Mathematics
subject: 20F65, 51E24

description: We study lattices on ~A_2 buildings that preserve types, act regularly on each type of edge, and whose vertex stabilizers are cyclic. We show that several of their properties, such as their automorphism group and isomorphism class, can be determined from purely combinatorial data. As a consequence we can show that the number of such lattices (up to isomorphism) grows super-exponentially with the thickness parameter q. We look in more detail at the 3295 lattices with q in {2,3,4,5}. We show that with one exception for each q these are all exotic. For the exotic examples we prove that the automorphism group of the lattice and of the building coincide, and that two lattices are quasi-isometric only if they are isomorphic.
description: 62 pages, 8 tables, 4 figures, v2 has appendix removed and abelianizations for q=5 corrected
Novel Compounds for Anti-Cancer Directed Enzyme Prodrug Therapy Utilising Nitroreductase
Creators: name: ANDREW TANG
Publisher: name: Monash University
Year: 2018
Subjects: subject: 30499 Medicinal and Biomolecular Chemistry not elsewhere classified
subject: FOS: Chemical sciences

description: Cancer is a disease with global impact and there is a constant need to develop new treatments to target it. One method is to take potent drugs and activate them at the tumour. We’ve been working on a strategy that will release potent drugs only when activated by a specific enzyme which can be delivered to the tumour. We have success designed a chemical system that only releases the payload in the presence of the enzyme. We hope that this design will be used to make anti-cancer drugs safer.
Error analysis of projection methods for non inf-sup stable mixed finite elements. The Navier-Stokes equations
Creators: name: de Frutos, Javier
name: García-Archilla, Bosco
name: Novo, Julia
Publisher: name: arXiv
Year: 2016
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics
subject: 65M12

description: We obtain error bounds for a modified Chorin-Teman (Euler non-incremental) method for non inf-sup stable mixed finite elements applied to the evolutionary Navier-Stokes equations. The analysis of the classical Euler non-incremental method is obtained as a particular case. We prove that the modified Euler non-incremental scheme has an inherent stabilization that allows the use of non inf-sup stable mixed finite elements without any kind of extra added stabilization. We show that it is also true in the case of the classical Chorin-Temam method. The relation of the methods with the so called pressure stabilized Petrov Galerkin method (PSPG) is established. We do not assume non-local compatibility conditions for the solution.
title: MGMT Promoter Methylation And BRAF V600E Mutations Are Helpful Markers To Discriminate Pleomorphic Xanthoastrocytoma From Giant Cell Glioblastoma
Creators: name: Koch, Arend
name: Bradtmöller, Maren
name: Lohkamp, Laura-Nanna
name: Gehlhaar, Claire
name: Guse, Katrin
name: Thomale, Ulrich-Wilhelm
name: Vajkoczy, Peter
name: Heppner, Frank
Publisher: name: German Medical Science GMS Publishing House
Year: 2015
Subjects: subject: 610 Medical sciences; Medicine

description: Giant Cell Glioblastoma (gcGBM) and Pleomorphic Xanthoastrocytoma (PXA) are rare astroglial tumors of the central nervous system. Although they share certain histomorphological and immunohistochemical features, they are characterized by different clinical behavior and prognosis. Nevertheless, few cases[for full text, please go to the a.m. URL]
description: 60th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN)
El sector financiero de Cartagena y su contribución al crecimiento económico de la ciudad
Creators: name: Alvarez Cuadrado, Enilce
name: Del Valle Medina, Bibiana
Publisher: name: Universidad de Cartagena
Year: 1989
Subjects: Bancos

description: Tesis (Economista) -- Universidad de Cartagena. Facultad de Ciencias Económicas. Programa de Economía. 1989.
description: El presente estudio tiene por objeto describir la estructura del sector financiero de Cartagena, estableciendo la participación que este ha tenido en el crecimiento económico de la ciudad.
Towards A Novel Non-Viral Gene Delivery System Based On Adenovirus Genome
Creators: name: HARETH BASIM ALI AL-WASSITI
Publisher: name: Monash University
Year: 2018
Subjects: subject: 100401 Gene and Molecular Therapy
subject: FOS: Medical biotechnology
subject: Genetic Engineering
subject: 60506 Virology
subject: FOS: Biological sciences

description: Gene therapy is a new form of medical treatment that delivers genetic "information” to treat diseases. In order to achieve a good outcome, a gene delivery system must reach the appropriate location inside the target cell after administration by injection. The project examined different ways to enhance the delivery of genetic information and investigated how the information is processed to achieve the desired therapeutic outcome. New delivery technologies were explored, using mechanisms used by viruses for inspiration. The results identified new opportunities to improve the performance of gene delivery systems to treat diseases such as cancer.
The practice of project management in Ethiopian real estate industry and its contribution to project success: The case of selected company in Addis Ababa
Creators: name: w/kidan, befkadu
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2017

description: The application of Project Management (PM) tools and techniques in public sector is gradually becoming an important issue in developing economies, especially in a country like Ethiopia where projects of different size and structures are undertaken. The paper examined the application of the project management practice in public sector in Ethiopia. There are different problems that are faced by Real Estate projects such as delay, nonperformance of projects, not meeting required specifications, and dissatisfaction of customers, etc. This study aims to assess the extent to which project management is applied in Ethiopian Real Estate projects and its contribution to success of these projects and to address the major causes of delay, cost escalation, and poor quality. Major data for the assessment are obtained from 24 Real Estate companies through questionnaire. Data are also gathered from 11 construction consultants, 3 instructors, and 44 Real Estate house owners for cross checking the information found from the Real Estate companies. Mean, standard deviation, correlation, regression, and other quantitative and qualitative analysis tools are used. IBM SPSS Statistics 20 computer applications is used to simplify long statistical computations. The findings reveal that Project integration, scope, time, HR, procurement, and claim are well managed in the Industry. In addition to this, Project initiation process groups and project closing process group are practiced well and consistently. On the contrary, the other knowledge areas and process groups are either poorly practiced or inconsistently applied or both throughout the Industry. It is also found that the practice of project management has significant contribution to success of Ethiopian Real Estate projects. Recommendations are forwarded for Real Estate companies to maintain their good project management practices that are mentioned above, to improve the other knowledge area and process group practices, to consider causes of delay, cost escalation, and poor quality while making project decisions, to continuously conduct customer satisfaction survey to cop up with the new dimension of project success, and to have project management Information Systems. It is advised to establish Real Estate Association at industry level and to set project management standards by government at national level. Finally, area for further study are indicated
The Development of HIV-1 Integrase Allosteric Inhibitors Using a Fragment Based Drug Discovery Approach
Creators: name: DAN ZHENG
Publisher: name: Monash University
Year: 2018
Subjects: subject: 111504 Pharmaceutical Sciences
subject: FOS: Clinical medicine
subject: 30503 Organic Chemical Synthesis
subject: FOS: Chemical sciences

description: HIV-1 integrase (IN) is an enzyme that is essential for viral replication. Previous work within our group identified a molecule as a hit that bound to IN and had potential to be developed as an inhibitor of HIV. This thesis describes the hit-to-lead optimisation process of developing the hit into a high-affinity lead compound using a Fragment-Based Drug Discovery approach. Overall, in this work 99 analogues were synthesised and evaluated using multiple assays. The binding affinity of the hit was improved by a factor of 700 thousand.
Programa educativo sobre lactancia materna y maloclusiones en bebés de 0 – 18 meses
Creators: name: Estremor Herrera, Angélica
name: Herrera De La Ossa, David
Publisher: name: Universidad de Cartagena
Year: 2020
Subjects: subject: Dientes - Malformaciones
subject: Maloclusión
subject: Articuladores Dentales
subject: Niños lactantes - Cuidado e higiene
subject: Lactancia materna

description: La lactancia ha demostrado ser un factor protector contra distintas enfermedades infectocontagiosas, del espectro atópico y cardiovasculares, así como contra la leucemia, enterocolitis necrotizante, enfermedad celíaca y enfermedades inflamatorias intestinales. Asimismo, tiene un impacto positivo en el neurodesarrollo, mejorando el coeficiente intelectual y pudiendo tener una disminución del riesgo de otras condiciones como el déficit atencional, trastorno generalizado del desarrollo y alteraciones de conducta. (1) Además de esto, en diversos estudios se plantea que el uso de fórmulas lácteas y otros tipos de complemento en la alimentación del bebé podrían aumentan el riesgo de las alteraciones de la cavidad oral, tales como respiración bucal, alteración de la mordida, caries y maloclusión.
Novel Agents Targeting Sphingolipid Signalling
Creators: name: CARMEN VITTORIA SCULLINO
Publisher: name: Monash University
Year: 2018
Subjects: subject: 111504 Pharmaceutical Sciences
subject: FOS: Clinical medicine

description: This thesis explores the sphingolipid pathway as a novel area of therapy in the treatment of cancer, fibrosis and multiple sclerosis. In a scaffold-hopping approach we have developed a compound library of drug-like non-lipid sphingolipid mimetics with improved phenotypic, physicochemical and pharmacokinetic activity relative to current frontrunners, as part of an ongoing optimisation effort. Our compounds further demonstrate a unique mechanism of action, which overcomes pathway redundancy of contemporary kinase inhibitors and receptor antagonists through phosphatase activation. As well as focusing on the development of viable drug candidates, this work further investigates the structure-activity relationship of our compounds in connection to activity.
Adding boundary terms to Anderson localized Hamiltonians leads to unbounded growth of entanglement
Creators: name: Huang, Yichen
Publisher: name: arXiv
Year: 2021
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: It is well known that in Anderson localized systems, starting from a random product state the entanglement entropy remains bounded at all times. However, we show that adding a single boundary term to an Anderson localized Hamiltonian leads to unbounded growth of entanglement. Our results imply that Anderson localization is not a local property. One cannot conclude that a subsystem has Anderson localized behavior without looking at the whole system, as a term that is arbitrarily far from the subsystem can affect the dynamics of the subsystem in such a way that the features of Anderson localization are lost.
description: v3: published version
Ehrenfest dynamics implemented in the all-electron package exciting
Creators: name: Pela, Ronaldo Rodrigues
name: Draxl, Claudia
Publisher: name: arXiv
Year: 2022
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Ehrenfest Dynamics combined with real-time time-dependent density functional theory has proven to be a reliable tool to study non-adiabatic molecular dynamics with a reasonable computational cost. Among other possibilities, it allows for assessing in real time electronic excitations generated by ultra-fast laser pulses, as e.g., in pump-probe spectroscopy, and their coupling to the nuclear vibrations even beyond the linear regime. In this work, we present its implementation in the all-electron full-potential package exciting. Three cases are presented as examples: diamond and cubic BN relaxed after an initial lattice distortion, and cubic BN exposed to a laser pulse. Comparison with the Octopus code exhibits good agreement.
On the mechanism of release from novel drug-polymer conjugates
Creators: name: IGOR CHEKHTMAN
Publisher: name: Monash University
Year: 2018
Subjects: subject: 111504 Pharmaceutical Sciences
subject: FOS: Clinical medicine
subject: 30505 Physical Organic Chemistry
subject: FOS: Chemical sciences

description: This thesis investigates the key processes controlling drug release from a novel delivery technology. It confirms that the physical and chemical properties of the device affect the mechanism of release, and identifies strategies for modifying the rate and duration of drug delivery.
Effective field theory for magnetic compactifications
Creators: name: Buchmuller, Wilfried
name: Dierigl, Markus
name: Dudas, Emilian
name: Schweizer, Julian
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: Magnetic flux plays an important role in compactifications of field and string theories in two ways, it generates a multiplicity of chiral fermion zero modes and it can break supersymmetry. We derive the complete four-dimensional effective action for N=1 supersymmetric Abelian and non-Abelian gauge theories in six dimensions compactified on a torus with flux. The effective action contains the tower of charged states and it accounts for the mass spectrum of bosonic and fermionic fields as well as their level-dependent interactions. This allows us to compute quantum corrections to the mass and couplings of Wilson lines. We find that the one-loop corrections vanish, contrary to the case without flux. This can be traced back to the spontaneous breaking of a symmetry of the six-dimensional theory by the background gauge field, with the Wilson line as Goldstone boson.
description: 34 pages, 6 figures; published version
Feldstudie zur Entwicklung der Rechenfertigkeit von Erstklässlern
Creators: name: Eilerts, Katja
name: Rinkens, Hans-Dieter
name: Seifert, Andreas
Publisher: name: Gesellschaft für Didaktik der Mathematik
Year: 2014
Subjects: subject: 510

description: Berichtet wird über eine Feldstudie mit über 2600 Erstklässlern in 128 Klassen gegen Ende des ersten Schuljahres. Getestet werden jeweils alle 231 Additions- sowie Subtraktionsaufgaben mit Ergebnissen im Zahlenraum bis 20, bestehend aus Aufgaben der Form "a + b =" bzw. "a –b =" (Testdesign siehe Rinkens, 2011). Im Vortrag werden vor allem die Ergebnisse des Subtraktionstests dargestellt. Es zeigt sich eine Unterteilung des Aufgabenpools in "leichte" und "schwere" Aufgaben, die nicht immer den intuitiven Vermutungen entspricht. Entscheidend für erfolgreiches Rechnen ist ein wachsender Bestand an verfügbaren Rechensätzen und an Rechenstrategien. Beides hängt zusammen: Rechenstrategien setzen einen Bestand an bekannten Rechensätzen voraus, die Erweiterung dieses Bestandes geschieht über Rechenstrategien. Die Rechensätze sind das Rohmaterial, die Rechenstrategien das Gewusst-wie des Rechnens. Die Automatisierung des Einspluseins und des Einsminuseins ist letztendlich Voraussetzung für die arithmetischen Themen der folgenden Schuljahre. Empirische Studien zur Entwicklung der Rechenkompetenz im ersten Schuljahr sind im deutschsprachigen Raum Mangelware (vgl. Padberg & Benz 2011). Meist sind es qualitative Studien zu Rechenstrategien (vgl. Gaidoschik 2010). Grassmann (2003) untersucht den Lernzuwachs bezogen auf ausgewählte Aufgaben, eingekleidet in Sachkontexten, zwischen Beginn und Ende des 1. Schuljahres in einer Stichprobe von 777 Kindern aus den Bundesländern Berlin, Brandenburg und Nordrhein-Westfalen.
On endomorphisms of the bicyclic semigroup and the extended bicyclic semigroup
Creators: name: Gutik, Oleg
name: Prokhorenkova, Oksana
name: Sekh, Diana
Publisher: name: arXiv
Year: 2022
Subjects: subject: Group Theory (math.GR)
subject: FOS: Mathematics
subject: 20M15, 20M50, 18B40

description: It is proved that the semigroups $\mathrm{\mathbf{End}}(\boldsymbol{B}_ω)$ and $\mathrm{\mathbf{End}}(\boldsymbol{B}_{\mathbb{Z}})$ of the endomorphisms of the bicyclic semigroup $\boldsymbol{B}_ω$ and the endomorphisms of the extended bicyclic semigroup $\boldsymbol{B}_{\mathbb{Z}}$ are isomorphic to the semidirect products $(ω,+)\rtimes_φ(ω,*)$ and $\mathbb{Z}(+)\rtimes_φ(ω,*)$, respectively.
description: 10 pages, in Ukrainian
DEVELOPMENT OF STEREOSELECTIVE SYNTHESES OF BROMODOMAIN INHIBITORS AS ANTI-CANCER DRUGS
Creators: name: MOHAMMAD AL AMIN
Publisher: name: Monash University
Year: 2018
Subjects: subject: 30401 Biologically Active Molecules
subject: FOS: Chemical sciences

description: This project explored the design, synthesis and testing of small molecules as anticancer agents. The compounds sought to block a particular family of (BET domain) proteins that affect cell growth. Specifically the research explored novel chemical scaffolds and required techniques to either synthesise or separate chiral substances. Encouragingly, these molecules were found to successfully block transcription pathways and represent an exciting new class of anticancer drugs that will be investigated further.
Structural Analysis of DNA molecule in a confined shell
Creators: name: Maity, Arghya
name: Mathur, Neha
name: Imhof, Petra
name: Singh, Navin
Publisher: name: arXiv
Year: 2022
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: Recent advances in operating and manipulating DNA have provided unique experimental possibilities in many fields of DNA research, especially in gene therapy. Researchers have deployed many techniques, experimental and theoretical, to study the DNA structure changes due to external perturbation. It is crucial to understand the structural and dynamical changes in the DNA molecules in a confined state to understand and control the self-assembly of DNA confined in a chamber or nano-channel for various applications. In the current manuscript, we extend the work study the effect of confinement on the thermal stability and the structural properties of duplex DNA. The present work is an extension of our previous research works. For our study we have considered a 1 BNA chain that is confined in a cylindrical geometry. How the geometry of the confinement affects the opening and other structural parameters of DNA molecule is the objective of this manuscript. We have used a statistical model(PBD model) and Molecular dynamics simulations for our purpose.
Activación dinámica manual VS láser de diodo en la eliminación del barrillo dentinario con naocl: revisión sistemática
Creators: name: Maestre Juvinao, Katerine
name: Gómez Gulfo, Melissa Del Carmen
Publisher: name: Universidad de Cartagena
Year: 2022
Subjects: subject: Endodoncia
subject: Canal radicular - Tratamiento
subject: Conductos radiculares
subject: Láseres semiconductores

description: La preparación biomecánica de los conductos radiculares implica la eliminación del barrillo dentinario o “smear layer” para lograr una desinfección completa, siendo factor clave de éxito del tratamiento endodóntico el uso de soluciones irrigadoras y técnicas de activación. Sin embargo, es necesario evaluar otras técnicas de activación como el uso del láser para establecer nuevos protocolos que garanticen mayor efectividad y disminución de procedimientos con fracaso endodóntico. Objetivo general: Examinar la evidencia disponible y establecer un estado del arte con relación a la efectividad de la activación dinámica manual y láser de diodo en la eliminación del barrillo dentinario con NaOCl. Materiales y métodos: Revisión sistemática de la literatura, a partir de estudios in vitro y ensayos clínicos aleatorizados, publicados en los últimos cinco años, disponibles en texto completo; en idiomas inglés y español; utilizando las bases de datos PubMed/MEDLINE, ScienceDirect, Scopus y Google Scholar. Se diseñó una estrategia de búsqueda por medio de la combinación de un vocabulario estructurado y términos libres. Para el proceso de selección de los estudios, dos autores examinaron los títulos de las publicaciones, limitándose la información de los resúmenes y texto completo para su inclusión mediante consenso y/o a través de un tercer revisor en caso de discrepancias, reportándose las razones de la exclusión de los estudios. Resultados: Se identificaron 285 artículos en total, de los cuales se incluyeron finalmente 11 artículos para esta revisión. Con relación a las características de los estudios incluidos de esta revisión se pudo analizar que el 100% de los artículos tenían un tipo de diseño in vitro. El láser de diodo a diferentes longitudes de onda con NaOCl + EDTA al 17% mostraron los mejores resultados para la reducción del barrillo dentinario. Sin embargo, la técnica de activación dinámica manual reportó cambios no significativos con el uso exclusivo del NaOCl a concentraciones de 2,5% y 5,25%. Conclusión: Es necesario el diseño y la implementación de estudios de intervención que permitan analizar los efectos del láser de diodo y la activación dinámica manual en la eliminación del barrillo dentinario, debido a que la evidencia científica reporta resultados no determinantes para la toma de decisiones clínicas.
Implementación de un sistema de control metrológico a los espesores de pinturas aplicados a los vehículos automotores intervenidos en el taller autos pintura Cartagena
Creators: name: Estrada Aguirre, Luis Carlos
name: Galofre Alvarado, Julián
name: Peña Muñoz, Lisley
Publisher: name: Universidad de Cartagena
Year: 2017
Subjects: Metrología
Instrumentos de medición

description: Tesis (Tecnólogo en Metrología Industrial). -- Universidad de Cartagena. Facultad de Ciencias Exactas y Naturales. Programa de Metrología, 2017
description: El presente trabajo se busca Implementar un sistema de control metrológico a los espesores de pinturas aplicados a los vehículos automotores intervenidos en el taller auto pintura
Tackling Polymyxin Resistance in Pseudomonas aeruginosa: A Multi-disciplinary Approach
Creators: name: MEILING HAN
Publisher: name: Monash University
Year: 2018
Subjects: subject: 111504 Pharmaceutical Sciences
subject: FOS: Clinical medicine
subject: Pharmacology

description: This thesis, for the first time, provides an important mechanistic insight into the comprehensive mechanisms of polymyxin resistance in P. aeruginosa through the integrated neutron reflectometry and systems pharmacological approaches. Our research highlighted the complex and dynamic interactions of multiple cellular metabolic pathways involved in the bacterial physiological response to polymyxins, and their potential as therapeutic targets. Our study has made a significant contribution to understanding polymyxin mode of action and helps to tackle polymyxin resistance in Gram-negative "superbugs".
Assessment Of Management Roles Effectiveness For Enterprise Resource Planning (ERP) System Implementation Success: The Case Of Ethiopian Electric Utility (EEU) ERP Project
Creators: name: mulushoa, Yohannes
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2019

description: This case study is conducted in Ethiopian Electric Utility (EEU) to assess Enterprise Resource Planning (ERP)implementation success based on Management Roles effectiveness. Thus the study;by adapting previous research work that tried to group related Critical Success Factors (CSFs) into five Management Roles, developed a research framework that associate the management roleseffectiveness with the ERP implementation success; and also by using various data collection methods (qualitative and quantitative) in combination with purposive sampling techniqueto select 167 samples and using the opinions of the project managers, core team members, end users and consultants/implementation partners assessed the implementation success, test the relationship and draw explanation. The result ofthe studyshows that; with the established criteria EEU's ERP implementation performance is under average;found that the Top Management, Technology Management, Process Management, Change Management and Project Management Roles have a strong and positive relationship with ERP implementation success; andall the management roles have a respectable amount of variance to explain the ERP Implementation Success. Additionally, in order to exploit the full potential from ERP, more efforts to be practiced to improve the effectiveness of the five management rolesand further research in the five management roles areas are recommendedfor the case of EEU.
Improving the management of enterococcal bacteraemia and prevention of vancomycin-resistant enterococci transmission in the Australian hospital setting
Creators: name: LOO YEE CHEAH
Publisher: name: Monash University
Year: 2017
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: This thesis addressed important knowledge gaps about the management of patients with bloodstream infection due to bacteria called enterococci and prevention of vancomycin-resistant enterococci spread in the Australian hospital setting. The thesis identified factors linked to the development and outcomes (for example, death in hospital, length of stay, hospitalisation costs) of vancomycin-resistant and -susceptible enterococci bloodstream infection. This thesis provided information on the effectiveness of infection control strategies to prevent VRE spread in a cancer ward. Information generated will assist healthcare practitioners to optimise the management of patients with bloodstream infection due to enterococci and prevention of vancomycin-resistant enterococci spread.
Probing Plasma Physics with Spectral Index Maps of Accreting Black Holes on Event Horizon Scales
Creators: name: Ricarte, Angelo
name: Gammie, Charles
name: Narayan, Ramesh
name: Prather, Ben S.
Publisher: name: arXiv
Year: 2022
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The Event Horizon Telescope (EHT) collaboration has produced the first resolved images of the supermassive black holes at the centre of our galaxy and at the centre of the elliptical galaxy M87. As both technology and analysis pipelines improve, it will soon become possible to produce spectral index maps of black hole accretion flows on event horizon scales. In this work, we predict spectral index maps of both M87* and Sgr A* by applying the general relativistic radiative transfer (GRRT) code IPOLE to a suite of general relativistic magnetohydrodynamic (GRMHD) simulations. We analytically show that the spectral index increases with increasing magnetic field strength, electron temperature, and optical depth. Consequently, spectral index maps grow more negative with increasing radius in almost all models, since all of these quantities tend to be maximised near the event horizon. Additionally, photon ring geodesics exhibit more positive spectral indices, since they sample the innermost regions of the accretion flow with the most extreme plasma conditions. Spectral index maps are sensitive to highly uncertain plasma heating prescriptions (the electron temperature and distribution function). However, if our understanding of these aspects of plasma physics can be tightened, even the spatially unresolved spectral index around 230 GHz can be used to discriminate between models. In particular, Standard and Normal Evolution (SANE) flows tend to exhibit more negative spectral indices than Magnetically Arrested Disk (MAD) flows due to differences in the characteristic magnetic field strength and temperature of emitting plasma.
description: Accepted for publication in MNRAS
A universal lower bound on the free energy cost of molecular measurements
Creators: name: Das, Suman G.
name: Iyengar, Garud
name: Rao, Madan
Publisher: name: arXiv
Year: 2016
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Molecular Networks (q-bio.MN)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: The living cell uses a variety of molecular receptors to read and process chemical signals that vary in space and time. We model the dynamics of such molecular level measurements as Markov processes in steady state, with a coupling between the receptor and the signal. We prove exactly that, when the the signal dynamics is not perturbed by the receptors, the free energy consumed by the measurement process is lower bounded by a quantity proportional to the mutual information. Our result is completely independent of the receptor architecture and dependent on signal properties alone, and therefore holds as a general principle for molecular information processing.
description: 12 pages, 3 figures
First contact breaking distributions in strained disordered crystals
Creators: name: Maharana, Roshan
name: Nampoothiri, Jishnu N.
name: Ramola, Kabir
Publisher: name: arXiv
Year: 2022
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We derive exact probability distributions for the strain ($ε$) at which the first stress drop event occurs in uniformly strained disordered crystals, with quenched disorder introduced through polydispersity in particle sizes. We characterize these first stress drop events numerically as well as theoretically, and identify them with the first contact breaking event in the system. Our theoretical results are corroborated with numerical simulations of quasistatic volumetric strain applied to disordered near-crystalline configurations of athermal soft particles. We develop a general technique to determine the $distribution$ of strains at which the first stress drop events occur, through an exact mapping between the cumulative distribution of first contact breaking events and the volume of a convex polytope whose dimension is determined by the number of defects $N_d$ in the system. An exact numerical computation of this polytope volume for systems with small numbers of defects displays a remarkable match with the distribution of strains generated through direct numerical simulations. Finally, we derive the distribution of strains at which the first stress drop occurs, assuming that individual contact breaking events are uncorrelated, which accurately reproduces distributions obtained from direct numerical simulations.
description: 17 pages, 12 figures
Some new results on integration for multifunction
Creators: name: Candeloro, Domenico
name: Di Piazza, Luisa
name: Musiał, Kazimierz
name: Sambucini, Anna Rita
Publisher: name: arXiv
Year: 2016
Subjects: subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 28B20, 26E25, 26A39, 28B05, 46G10, 54C60, 54C65

description: It has been proven in previous papers that each Henstock-Kurzweil-Pettis integrable multifunction with weakly compact values can be represented as a sum of one of its selections and a Pettis integrable multifunction. We prove here that if the initial multifunction is also Bochner measurable and has absolutely continuous variational measure of its integral, then it is a sum of a strongly measurable selection and of a variationally Henstock integrable multifunction that is also Birkhoff integrable.
description: 15 pages
Bias-Scalable Near-Memory CMOS Analog Processor for Machine Learning
Creators: name: Kumar, Pratik
name: Nandi, Ankita
name: Chakrabartty, Shantanu
name: Thakur, Chetan Singh
Publisher: name: arXiv
Year: 2022
Subjects: subject: Emerging Technologies (cs.ET)
subject: Artificial Intelligence (cs.AI)
subject: Hardware Architecture (cs.AR)
subject: Machine Learning (cs.LG)
subject: Systems and Control (eess.SY)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Bias-scalable analog computing is attractive for implementing machine learning (ML) processors with distinct power-performance specifications. For instance, ML implementations for server workloads are focused on higher computational throughput for faster training, whereas ML implementations for edge devices are focused on energy-efficient inference. In this paper, we demonstrate the implementation of bias-scalable approximate analog computing circuits using the generalization of the margin-propagation principle called shape-based analog computing (S-AC). The resulting S-AC core integrates several near-memory compute elements, which include: (a) non-linear activation functions; (b) inner-product compute circuits; and (c) a mixed-signal compressive memory, all of which can be scaled for performance or power while preserving its functionality. Using measured results from prototypes fabricated in a 180nm CMOS process, we demonstrate that the performance of computing modules remains robust to transistor biasing and variations in temperature. In this paper, we also demonstrate the effect of bias-scalability and computational accuracy on a simple ML regression task.
description: 11 pages, 11 figures, 2 Tables
Partial orderings of default predictions
Creators: name: Krämer, Walter
name: Posch, Peter N.
Publisher: name: Technische Universität Dortmund
Year: 2015
Subjects: subject: probability forecasts
subject: partial ordering
subject: rating systems
subject: 310
subject: 330
subject: 620

description: We compare and generalize various partial orderings of probability forecasters according to the quality of their predictions. It appears that the calibration requirement is quite at odds with the possibility of some such ordering. However, if the requirements of calibration and identical sets of debtors are relaxed, comparability obtains more easily. Taking default predictions in the credit rating industry as an example, we show for a data base of 5333 (Moody’s) and 6505 ten-year default predictions (S&P), that Moody’s and S&P cannot be ordered neither according to their grade distributions given default or non-default or to their Ginicurves, but Moody’s dominate S&P with respect to the ROC-criterion.
description: Discussion Paper / SFB 823;31/2015
De la paternidad responsable y del hijo natural en el derecho positivo colombiano"
Creators: name: Camacho Orozco, Pedro Rafael
Publisher: name: Universidad de Cartagena
Year: 1971
Subjects: Hijos naturales

description: Tesis (Abogado) -- Universidad de Cartagena. Facultad de Derecho y Ciencias Políticas. Programa de Derecho, 1971
description: Comentario de la ley sobre paternidad responsable sobre sus aspectos positivos y negativos de manera específica en lo relativo al hijo natural.
title: Proteasome immunosubunits in the pathogenesis of myopathies
Creators: name: Bhattarai, Salyan
name: Ghannam, Khetam
name: Stenzel, Werner
name: Gamboa Martinez, Lorena
name: Spuler, Simone
name: Benveniste, Olivier
name: Feist, Eugen
Publisher: name: German Medical Science GMS Publishing House
Year: 2015
Subjects: subject: 610 Medical sciences; Medicine

description: Introduction: Idiopathic inflammatory myopathies (IIM) are characterized by infiltration of immune cells into muscle and upregulation of MHC-I molecule. Previously, we found mRNA of that IFN-γ inducible proteasome subunits (β1i and β5i) significantly increased in IIM muscle biopsies[for full text, please go to the a.m. URL]
description: 60th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN)
Towards Non-Volatile Spin Orbit Devices: Deposition of Ferroelectric Hafnia on Monolayer Graphene/Co/HM Stacks
Creators: name: Lancaster, Suzanne
name: Arnay, Iciar
name: Guerrero, Ruben
name: Gudín, Adrian
name: Guedeja-Marrón, Alejandra
name: Toledano, Jose Manuel Diez
name: Gärtner, Jan
name: Anadón, Alberto
name: Varela, Maria
name: Camarero, Julio
name: Mikolajick, Thomas
name: Perna, Paolo
name: Slesazeck, Stefan
Publisher: name: arXiv
Year: 2021
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: Although technologically challenging, the integration of ferroelectric thin films with graphene spintronics potentially allows the realization of highly efficient, electrically tuneable, non-volatile memories. Here, the atomic layer deposition (ALD) of ferroelectric Hf$_{0.5}$Zr$_{0.5}$O$_2$ (HZO) directly on graphene (Gr)/Co/heavy metal (HM) epitaxial stacks is investigated via the implementation of several nucleation methods. With an in-situ method employing an Al$_2$O$_3$ layer, the HZO demonstrates a remanent polarization (2Pr) of 19.2 $μC/cm^2$. An ex-situ, naturally oxidized sputtered Ta layer for nucleation produces a film with 2Pr of 10.81 $μC/cm^2$, but a lower coercive field over the stack and switching enduring over subsequent cycles. Magnetic hysteresis measurements taken before and after ALD deposition show strong perpendicular magnetic anisotropy (PMA), with only slight deviations in the magnetic coercive fields due to the HZO deposition process, thus pointing to a good preservation of the single-layer Gr. X-ray diffraction measurements further confirm that the high-quality interfaces demonstrated in the stack remain unperturbed by the ferroelectric deposition and anneal.
description: Accepted at ACS Applied Materials & Interfaces