A new EURAMET EMPIR Project: establishing metrology standards in microfluidic devices
Creators: name: Ogheard, Florestan
name: Batista, Elsa
name: Tzannis, Alexios
name: Becker, Holger
name: Silverio, Vania
name: Graham, Emmelyn
Publisher: name: Zenodo
Year: 2021
Subjects: Microfluidics
Metrology
Standards

description: In 2021, an new EURAMET EMPIR-funded project, MFMET – Establishing metrology standards in microfluidic devices- will start. The goal of this project is to contribute to the development of globally accepted standards for microfluidic devices and disseminate them to end users in industry, particularly Life Science and Diagnostics Companies, and in academia. This project will focus on testing and metrology strategies that are essential to ensure measurement accuracy and traceability of microfluidic devices and will aid product developers in advancing the field of microfluidics. The project partners will interact with ISO/TC48/WG3 for the development of microfluidic standards, covering metrology for the methodologies and fabrication processes. This project will also develop protocols for measuring different quantities, interface, connectivity, modularity and sensor integration of microfluidic devices<br> based on experimental test results obtained by the new microfluidic transfer standards fabricated by the consortium and literature surveys. The overall objective of this project is to focus on metrology research necessary to support standardisation for microfluidics used in the health and pharmaceutical industry. This project will develop protocols for measuring different quantities, interfaces, connectivity, modularity and sensor integration in microfluidic devices. The protocols implemented in new transfer standards fabricated under this project and literature surveys will integrate the standards prepared by ISO/TC48/WG3. The specific objectives, are: 1. To investigate, evaluate and formulate consensus-based flow control specifications to enhance the manufacturing capability of the microfluidics industry supply chain through voluntary compliance. 2. To develop measurement protocols for different quantities, (e.g. flow rate and liquid properties) in different microfluidics devices to be used in pharmaceuticals, biomedical and mechanobiology applications. A EURAMET guide on these measurement protocols will be developed. 3. To define general standards and guidelines for interfaces and connectivity between fluidic passages and optical/electrical connections of microfluidics components and corresponding measurement standards, from micro to macro size scales. 4. To define guidelines for the standardisation of dimensions and accuracy for modularity (either moduleto-module or module-to-world) and sensor integration (combination of sensing elements/materials with microfluidic modules). 5. To contribute to the standards development work of ISO/TC 48/WG3 to ensure that the outputs of the project are aligned with their needs. The project outputs from objective 1-4 will be communicated and disseminated quickly to those developing the standards and to those who will use them (health and pharmaceutical industry), and in a form (e.g. specifications, guidelines and white papers) that can be incorporated into the standards (e.g. new technical guides, ISO 10991 and ISO/CD 22916) at the earliest opportunity. The present publication will detail the state of the art, the underlying needs, the objectives, and the means implemented to establish new metrology standards in microfluidic devices. This work performed under MFMET project has received funding from the EMPIR programme co-financed by the Participating States and from the European Union’s Horizon 2020 research and innovation programme<br>
description: This project (Euramet 20NRM02 MFMET) has received funding from the EMPIR programme co-financed by the Participating States and from the European Union's Horizon 2020 research and innovation programme.