title: ÐÐ·ÑÑÐµÐ½Ð¸Ðµ Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð²Ð¸ÑÑÑÐ½Ð¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´Ð½ÑÑ Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ½ÑÑ ÑÐ»ÐµÐºÑÑÐ¾Ð»Ð¸ÑÐ¾Ð² Ð² Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ð¸ ÑÐµÑÐ¿Ð¸ÑÐ°ÑÐ¾ÑÐ½Ð¾-ÑÐ¸Ð½ÑÐ¸ÑÐ¸Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ Ð²Ð¸ÑÑÑÐ°
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Research of the antiviral activity of derivatives of polymer electrolytes against the respiratory syncytial virus
Creators: name: ÐÐ°Ð½Ð°ÑÐ¾Ð², ÐÐ¸ÑÐ°Ð»Ð¸Ð¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2023
Subjects: Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÑ
rsv a2
Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð²Ð¸ÑÑÑÐ½Ð°Ñ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ
in vitro
in vivo
polymers
antiviral activity
inÂ vitro

description: Ð¦ÐµÐ»ÑÑ Ð´Ð°Ð½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ Ð±ÑÐ»Ð¾ Ð¾ÑÐµÐ½Ð¸ÑÑ Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½Ð¾ÑÑÑ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ¾Ð² ÐºÐ°Ðº Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð²Ð¸ÑÑÑÐ½ÑÐµ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÑ, Ð¿ÑÐ¾Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°ÑÑ ÑÐ¸ÑÐ¾Ð¿Ð°ÑÐ¸ÑÐµÑÐºÐ¾Ðµ Ð´ÐµÐ¹ÑÑÐ²Ð¸Ðµ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ð¹ Ð´Ð°Ð½Ð½Ð¾Ð¹ Ð³ÑÑÐ¿Ð¿Ñ, Ð¿ÑÐ¸Ð²ÐµÑÑÐ¸ ÑÑÐ°Ð²Ð½Ð¸ÑÐµÐ»ÑÐ½ÑÑ ÑÐ°ÑÐ°ÐºÑÐµÑÐ¸ÑÑÐ¸ÐºÑ Ð¿Ð¾ Ð³ÑÑÐ¿Ð¿Ð°Ð¼. ÐÐ° Ð¿ÐµÑÐ²Ð¾Ð¼ ÑÑÐ°Ð¿Ðµ ÑÐ°Ð±Ð¾ÑÑ Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ Ð¼ÐµÑÐ¾Ð´Ð¾Ð² ÐÐ¢Ð¢ Ð¸ ÐÐ¤Ð Ð¿Ð¾Ð»ÑÑÐµÐ½Ñ ÑÐ¸ÑÐ»ÐµÐ½Ð½ÑÐµ Ð·Ð½Ð°ÑÐµÐ½Ð¸Ñ ÑÐ¸ÑÐ¾ÑÐ¾ÐºÑÐ¸ÑÐ½Ð¾ÑÑÐ¸ Ð¸ Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð²Ð¸ÑÑÑÐ½Ð¾Ð¹ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð² Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ð¸ ÑÐµÑÐ¿Ð¸ÑÐ°ÑÐ¾ÑÐ½Ð¾-ÑÐ¸Ð½ÑÐ¸ÑÐ¸Ð°Ð»ÑÐ½Ð¾Ð³Ð¾ Ð²Ð¸ÑÑÑÐ° Ð´Ð»Ñ ÐºÐ°Ð¶Ð´Ð¾Ð³Ð¾ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ°. ÐÐ· 41 Ð¸Ð·ÑÑÐµÐ½Ð½ÑÑ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ð¹ 26 Ð¾Ð±Ð»Ð°Ð´Ð°ÑÑ Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð²Ð¸ÑÑÑÐ½Ð¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑÑ. ÐÐ±ÑÐ°Ð±Ð¾ÑÐºÐ° ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐ¾Ð² Ð²ÐµÐ»Ð°ÑÑ Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð¼ÐµÑÐ¾Ð´Ð¾Ð² Ð¾Ð±ÑÐ°Ð±Ð¾ÑÐºÐ¸ Ð½ÐµÐ»Ð¸Ð½ÐµÐ¹Ð½ÑÑ ÑÐµÐ³ÑÐµÑÑÐ¸Ð¹ Ð² Ð¿ÑÐ¾Ð³ÑÐ°Ð¼Ð¼Ð½Ð¾Ð¼ Ð¿Ð°ÐºÐµÑÐµ GraphPad Prism. Ð¢Ð°Ðº Ð¶Ðµ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð»Ð¸ÑÑ Ð±Ð¸Ð±Ð»Ð¸Ð¾ÑÐµÐºÐ¸ Python scipy Ð¸ matplotlib. ÐÐ¾ Ð²ÑÐ¾ÑÑÑ ÑÐ°Ð·Ñ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ° Ð±ÑÐ»Ð¾ Ð¾ÑÐ¾Ð±ÑÐ°Ð½Ð¾ Ð½ÐµÑÐºÐ¾Ð»ÑÐºÐ¾ Ð½Ð°Ð¸Ð±Ð¾Ð»ÐµÐµ Ð¿ÐµÑÑÐ¿ÐµÐºÑÐ¸Ð²Ð½ÑÑ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ð¹ Ð´Ð»Ñ Ð¾ÑÐµÐ½ÐºÐ¸ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð² Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ð¸ Ð Ð¡-Ð²Ð¸ÑÑÑÐ° in vivo. ÐÐ·ÑÑÐµÐ½Ð½ÑÐµ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ñ Ð¾Ð±Ð»Ð°Ð´Ð°ÑÑ Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð²Ð¸ÑÑÑÐ½Ð¾Ð¹ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑÑ, Ð½Ð¾ Ð¼ÐµÐ½ÑÑÐµÐ¹, ÑÐµÐ¼ Ñ ÑÐ¸Ð±Ð°Ð²Ð¸ÑÐ¸Ð½Ð°. Ð ÑÑÐµÑÑÑ ÑÐ°Ð·Ñ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ° ÑÐ°ÑÑÑ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ¾Ð² Ð¾ÑÐ¾Ð±ÑÐ°Ð½Ð° Ð½Ð° Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ ÑÐ¿ÐµÐºÑÑÐ° Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸. ÐÐ¸ÑÑ Ð¾Ð´Ð¸Ð½ Ð¿ÑÐµÐ¿Ð°ÑÐ°Ñ Ð¾Ð±Ð»Ð°Ð´Ð°ÐµÑ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑÑ Ð² Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ð¸ ÐÐÐ§ 1 ÑÐ¸Ð¿Ð°, Ð² Ð¾ÑÐ½Ð¾ÑÐµÐ½Ð¸Ð¸ Ð³ÑÐ¸Ð¿Ð¿Ð° Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ Ð½Ðµ Ð²ÑÑÐ²Ð»ÐµÐ½Ð°. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¿Ð¾ÐºÐ°Ð·ÑÐ²Ð°ÑÑ, ÑÑÐ¾ Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ½ÑÐµ ÑÐ»ÐµÐºÑÑÐ¾Ð»Ð¸ÑÑ Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½Ð¾ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°ÑÑ Ð² ÐºÐ°ÑÐµÑÑÐ²Ðµ Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð²Ð¸ÑÑÑÐ½ÑÑ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ¾Ð².
description: The purpose of this work was to evaluate the possibility of using polymers as antiviral drugs, to analyze the cytopathic effect of the compounds of this group, and to give a comparative description of the groups. At the first stage of work, numerical values of cytotoxicity and antiviral efficacy against respiratory syncytial virus were obtained for each drug with using the MTT and ELISA methods. Of the 41 compounds studied, 26 have antiviral activity. The results were processed using non-linear regression processing methods in the GraphPad Prism software package. The Python libraries scipy and matplotlib were also used. In the second phase of the experiment, several of the most promising compounds were selected to evaluate the effectiveness against the RS virus in vivo. The studied compounds have antiviral activity, but less than that of ribavirin. In the third phase of the experiment, some preparations were selected for the research of the activity spectrum. Only one drug has activity against HHV type 1; no activity has been detected against influenza. The results obtained show that polymer electrolytes can be used as antiviral drugs.