cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Monitoring extracellular pH, oxygen, and dopamine during reward delivery in the striatum of primates
Creators: name: Phillips, Paul E. M.
name: Heien, Michael L. A. V.
name: Hermans, Andre
name: Bermudez, Maria A.
name: Wightman, R. Mark
name: Ariansen, Jennifer L.
name: Schultz, Wolfram
name: Hernadi, Istvan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Dopamine projections that extend from the ventral tegmental area to the striatum have been implicated in the biological basis for behaviors associated with reward and addiction. Until recently, it has been difficult to evaluate the complex balance of energy utilization and neural activity in the striatum. Many techniques such as electrophysiology, functional magnetic resonance imaging (fMRI), and fast-scan cyclic voltammetry have been employed to monitor these neurochemical and neurophysiological changes. In this brain region, physiological responses to cues and rewards cause local, transient pH changes. Oxygen and pH are coupled in the brain through a complex system of blood flow and metabolism as a result of transient neural activity. Indeed, this balance is at the heart of imaging studies such as fMRI. To this end, we measured pH and O2 changes with fast-scan cyclic voltammetry in the striatum as indices of changes in metabolism and blood flow in vivo in three Macaca mulatta monkeys during reward-based behaviors. Specifically, the animals were presented with Pavlovian conditioned cues that predicted different probabilities of liquid reward. They also received free reward without predictive cues. The primary detected change consisted of pH shifts in the striatal extracellular environment following the reward predicting cues or the free reward. We observed three types of cue responses that consisted of purely basic pH shifts, basic pH shifts followed by acidic pH shifts, and purely acidic pH shifts. These responses increased with reward probability, but were not significantly different from each other. The pH changes were accompanied by increases in extracellular O2. The changes in pH and extracellular O2 are consistent with current theories of metabolism and blood flow. However, they were of sufficient magnitude that they masked dopamine changes in the majority of cases. The findings suggest a role of these chemical responses in neuronal reward processing.
สถานภาพการวิจัยวรรณกรรมท้องถิ่นภาคกลางในรอบสองทศวรรษ (พ.ศ. 2540 - 2560)
Creators: name: พัชลินจ์ จีนนุ่น
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2021
Subjects: สถานภาพการวิจัย
วรรณกรรมท้องถิ่นภาคกลาง
ประเทศไทย

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 21, 1, 214-237
Optogenetic stimulation of VTA dopamine neurons reveals that tonic but not phasic patterns of dopamine transmission reduce ethanol self-administration
Creators: name: Day-Brown, Jonathan D.
name: Weiner, Jeff L.
name: Gioia, Dominic
name: Bonin, Keith D.
name: Bass, Caroline E.
name: Grinevich, Valentina P.
name: Stuber, Garret D.
name: Budygin, Evgeny A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: There is compelling evidence that acute ethanol exposure stimulates ventral tegmental area (VTA) dopamine cell activity and that VTA-dependent dopamine release in terminal fields within the nucleus accumbens plays an integral role in the regulation of ethanol drinking behaviors. Unfortunately, due to technical limitations, the specific temporal dynamics linking VTA dopamine cell activation and ethanol self-administration are not known. In fact, establishing a causal link between specific patterns of dopamine transmission and ethanol drinking behaviors has proven elusive. Here, we sought to address these gaps in our knowledge using a newly developed viral-mediated gene delivery strategy to selectively express Channelrhodopsin-2 (ChR2) on dopamine cells in the VTA of wild-type rats. We then used this approach to precisely control VTA dopamine transmission during voluntary ethanol drinking sessions. The results confirmed that ChR2 was selectively expressed on VTA dopamine cells and delivery of blue light pulses to the VTA induced dopamine release in accumbal terminal fields with very high temporal and spatial precision. Brief high frequency VTA stimulation induced phasic patterns of dopamine release in the nucleus accumbens. Lower frequency stimulation, applied for longer periods mimicked tonic increases in accumbal dopamine. Notably, using this optogenetic approach in rats engaged in an intermittent ethanol drinking procedure, we found that tonic, but not phasic, stimulation of VTA dopamine cells selectively attenuated ethanol drinking behaviors. Collectively, these data demonstrate the effectiveness of a novel viral targeting strategy that can be used to restrict opsin expression to dopamine cells in standard outbred animals and provide the first causal evidence demonstrating that tonic activation of VTA dopamine neurons selectively decreases ethanol self-administration behaviors.
พหุวัฒนธรรมกับการปฏิวัติ: ประวัติศาสตร์ความสัมพันธ์ระหว่างพรรคคอมมิวนิสต์จีนกับขบวนการทางสังคมแนวพุทธ
Creators: name: วาสนา วงศ์สุรวัฒน์
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2021
Subjects: พหุวัฒนธรรม
พรรคคอมมิวนิสต์จีน
สมาคมลับ
ฝ่าหลุนกง

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 21, 1, 238-268
Quark Wigner distributions in a light-cone spectator model
Creators: name: Liu, Tianbo
name: Ma, Bo-Qiang
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We investigate the quark Wigner distributions in a light-cone spectator model. The Wigner distribution, as a quasi-distribution function, provides the most general one-parton information in a hadron. Combining the polarization configurations, unpolarized, longitudinal polarized or transversal polarized, of the quark and the proton, we can define 16 independent Wigner distributions at leading twist. We calculate all these Wigner distributions for the $u$ quark and the $d$ quark respectively. In our calculation, both the scalar and the axial-vector spectators are included, and the Melosh-Wigner rotation effects for both the quark and the axial-vector spectator are taken into account. The results provide us a very rich picture of the quark structure in the proton.
description: 28 pages, 11 figures, version accepted for publication in PRD
Astrocyte IP3R2-dependent Ca2+ signaling is not a major modulator of neuronal pathways governing behavior
Creators: name: Petravicz, Jeremy
name: Boyt, Kristen M.
name: McCarthy, Ken D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Calcium-dependent release of gliotransmitters by astrocytes is reported to play a critical role in synaptic transmission and be necessary for long-term potentiation (LTP), long-term depression (LTD) and other forms of synaptic modulation that are correlates of learning and memory. Further, physiological processes reported to be dependent on Ca2+ fluxes in astrocytes include functional hyperemia, sleep, and regulation of breathing. The preponderance of findings indicate that most, if not all, receptor dependent Ca2+ fluxes within astrocytes are due to release of Ca2+ through IP3 receptor/channels in the endoplasmic reticulum. Findings from several laboratories indicate that astrocytes only express IP3 receptor type 2 (IP3R2) and that a knockout of IP3R2 obliterates the GPCR-dependent astrocytic Ca2+ responses. Assuming that astrocytic Ca2+ fluxes play a critical role in synaptic physiology, it would be predicted that elimination of astrocytic Ca2+ fluxes would lead to marked changes in behavioral tests. Here, we tested this hypothesis by conducting a broad series of behavioral tests that recruited multiple brain regions, on an IP3R2 conditional knockout mouse model. We present the novel finding that behavioral processes are unaffected by lack of astrocyte IP3R-mediated Ca2+ signals. IP3R2 cKO animals display no change in anxiety or depressive behaviors, and no alteration to motor and sensory function. Morris water maze testing, a behavioral correlate of learning and memory, was unaffected by lack of astrocyte IP3R2-mediated Ca2+-signaling. Therefore, in contrast to the prevailing literature, we find that neither receptor-driven astrocyte Ca2+ fluxes nor, by extension, gliotransmission is likely to be a major modulating force on the physiological processes underlying behavior.
The macro-policies and micropolitics influencing pre-service secondary school physical education teachers’ interpretations of pedagogy, when using a gymnastics interactive mobile website at one university in England
Creators: name: McVeigh, Joanne
Publisher: name: Loughborough University
Year: 2019
Subjects: subject: 119999 Medical and Health Sciences not elsewhere classified
subject: FOS: Other medical sciences

description: This study reports on the use of a purposefully designed bespoke mobile website, as part of a gymnastics module of work (10 weeks), on a Post Graduate Certificate of Education course in 2014. This involved 23 (f = 13 / m = 10) secondary physical education (PE) pre-service teachers, a teacher educator (female) and me (researcher, website designer and teacher educator). Additionally, a pilot study was conducted in 2013 (2 weeks), involving 24 PE pre-service teachers, with the aim of testing the mobile website’s usability. The intent of the mobile website was to support the development of pedagogical content knowledge and constructivist pedagogies of PE pre-service teachers, as they learnt to teach gymnastics. [Continues.]
การสร้างโมเดล 4PBL สำหรับการพัฒนากระบวนการเรียนการสอนวิชาการแปลภาษาจีนเป็นภาษาไทยและภาษาไทยเป็นภาษาจีนในระดับอุดมศึกษา
Creators: name: กนกพร นุ่มทอง
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2021
Subjects: การเรียนการสอน
การแปล
ภาษาจีน
โมเดล 4PBL

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 21, 1, 269-297
The Effectiveness of a School-based Addiction Prevention Program: Pilot Evaluation of Rajasthan Addiction Prevention Project (RAPP)
Creators: name: Sharma, Sadhana
name: Sharma, Dr. Neha
name: Singhal, Sahil
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 420899
subject: Traditional, complementary and integrative medicine not elsewhere classified
classificationCode: 420313
subject: Mental health services
classificationCode: 420399
subject: Health services and systems not elsewhere classified

description: It is widely acknowledged globally that parents must advocate for their children's drug and substance abuse prevention. However, many parents find it difficult to advocate due to systemic and logistical barriers. Alternatives to introducing advocacy, awareness, and support for the prevention of drug and substance abuse to children could occur in schools. However, little research has been conducted on the development of advocates for substance abuse in school settings. Present study was undertaken to evaluate the effectiveness of a school-based addiction prevention and control created as part of the Rajasthan Addiction Prevention Project (partnership between state-community initiative).
The fixed subgroups of homeomorphisms of Seifert manifolds
Creators: name: Zhang, Qiang
Publisher: name: arXiv
Year: 2015
Subjects: subject: Geometric Topology (math.GT)
subject: Group Theory (math.GR)
subject: FOS: Mathematics
subject: 57M05, 57M07, 37C25

description: Let $M$ be a compact connected orientable Seifert manifold with hyperbolic orbifold $B_M$, and $f_π: π_1(M)\rightarrowπ_1(M)$ be an automorphism induced by an orientation-reversing homeomorphism $f$ of $M$. We give a bound on the rank of the fixed subgroup of $f_π$, namely, $\rank\fix(f_π)<2\rank π_1(M)$, which is similar to the inequalities on surface groups and hyperbolic 3-manifold groups.
description: To appear in Acta Mathematica Sinica, English Series
Involvement of phospholipase C signaling in melanoma cell-induced endothelial junction disassembly
Creators: name: Peng, Hsin-Hsin,
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2005

description: In this study, we report a phospholipase C (PLC)-mediated mechanism for the redistribution of interendothelial adherens junctions in response to melanoma cell contacts with the endothelium. We demonstrated that contact of melanoma cells to human umbilical vein endothelial cells (HUVEC) triggered rapid endothelial [Ca2+]i response through PLC-IP3 pathway. In addition, alternation of endothelial adherens junctions following contact of melanoma cells was evidenced by the changes in immunological staining patterns of vascular endothelial (VE)-cadherin. A PLC inhibitor, {"type":"entrez-nucleotide","attrs":{"text":"U73122","term_id":"4098075","term_text":"U73122"}}U73122 was shown to significantly diminish [Ca2+]i response and reduce the occurrence of melanoma cell–induced VE-cadherin reorganization. Moreover, inhibition of PLC attenuated melanoma cell transendothelial migration. However, melanoma cell-associated VE-cadherin breakdown was not sensitive to Ly294002, an inhibitor of phosphatidylinositol-3-kinase (PI3K), whereas inhibition of PI3K resulted in a reduction of melanoma cell transmigration. Taken together, our findings implicate that by inducing the PLC-Ca2+ signaling pathway, melanoma cells disrupt EC junctions to breach the endothelium and promote transvascular homing of tumor cells.
Live Group Detection for Mobile Wireless Sensor Networks
Creators: name: Lauzier, Matthieu
name: Risset, Tanguy
name: Fraboulet, Antoine
name: Gorce, Jean-Marie
Publisher: name: arXiv
Year: 2015
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: This paper deals with distributed algorithms for monitoring the topology of a dynamic group of mobile wireless sensor networks. We propose two major extensions of a distributed static group consensus algorithm and an experimental implementation. Group consensus algorithms are exploited to let each node obtain the knowledge of its connected com-ponents. The proposed extensions provide a more accurate information about the proximity of nodes and allow to deal with dynamic networks using a periodical reevaluation of the group detection. We validate these algorithms by implementing them in an original and challenging application scenario, in the context of a real bicycle race. The real traces thus obtained and analyzed show the effectiveness of our live group detection implementation.
description: BodyNets 2014 - 9th International Conference on Body Area Networks, Sep 2014, Londres, United Kingdom
Endothelial signaling in paracellular and transcellular leukocyte transmigration
Creators: name: Wittchen, Erika, S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: As the primary physical barrier between blood and tissue compartments within the body, blood vessel endothelial cells and integrity of the cell junctions connecting them must be carefully regulated to support leukocyte transendothelial migration only when necessary. Leukocytes utilize two independent routes across the endothelium: the paracellular route involves migration in-between adjacent endothelial cells and requires the transient disassembly of endothelial cell junctions, while the transcellular route occurs directly through an individual endothelial cell, likely requiring the formation of a channel or pore. In this review, I will first summarize the signaling events that are transduced by leukocyte engagement of endothelial cell-surface receptors like ICAM-1 and VCAM-1. Some of these signals include activation of GTPases, production of reactive oxygen species, and phosphorylation of target proteins. These signaling pathways converge to cause junctional disruption, cytoskeletal remodeling, and/or the membrane fusion events that are associated with leukocyte transendothelial migration. The review will conclude with a detailed discussion of the newly characterized transmigratory cup structure, and the recent advances made towards understanding the mechanisms of transcellular transendothelial migration.
LIBSENSE: Building communities to strengthen open access and open science in Africa
Creators: name: Oaiya, Omo
Publisher: name: Zenodo
Year: 2022

description: Apresentação realizada na Conferência de Encerramento da 13ª Conferência Lusófona de Ciência Aberta, formato híbrido, de 10 a 12 de outubro de 2022.
Ärgerlich: Haschisch-Urteil des BVG und die unverhältnismäßigen Reaktionen
Creators: name: Foitzik, Alexander
Publisher: name: Herder Korrespondenz
Year: 1970

description: Herder Korrespondenz, Bd. 48 Nr. 7 (1994): Herder Korrespondenz, Band 48, Heft 7
Replication licensing and the DNA damage checkpoint
Creators: name: Cook, Jeanette Gowen
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Accurate and timely duplication of chromosomal DNA requires that replication be coordinated with processes that ensure genome integrity. Significant advances in determining how the earliest steps in DNA replication are affected by DNA damage have highlighted some of the mechanisms to establish that coordination. Recent insights have expanded the relationship between the ATM and ATR-dependent checkpoint pathways and the proteins that bind and function at replication origins. These findings suggest that checkpoints and replication are more intimately associated than previously appreciated, even in the absence of exogenous DNA damage. This review summarizes some of these developments.
Searches for the role of spin and polarization in gravity: a five-year update
Creators: name: Ni, Wei-Tou
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Searches for the role of spin in gravitation dated before the firm establishment of the electron spin in 1925. Since mass and spin, or helicity in the case of zero mass, are the Casimir invariants of the Poincaré group and mass participates in universal gravitation, these searches are natural steps to pursue. In this update, we report on the progress on this topic in the last five years after our last review. We begin with how is Lorentz/Poincaré group in local physics arisen from spacetime structure as seen by photon and matter through experiments/observations. The cosmic verification of the Galileo Equivalence Principle for photons/electromagnetic wave packets (Universality of Propagation in spacetime independent of photon energy and polarization, i.e. nonbirefringence) constrains the spacetime constitutive tensor to high precision to a core metric form with an axion degree and a dilaton degree of freedom. Hughes-Drever-type experiments then constrain this core metric to agree with the matter metric. Thus comes the metric with axion and dilation. In local physics this metric gives the Lorentz/Poincaré covariance. Constraints on axion and dilaton from polarized/unpolarized laboratory/astrophysical/cosmic experiments/observations are presented. In the end, we review the theoretical progress on the issue of gyrogravitational ratio for fundamental particles and the experimental progress on the measurements of possible long range/intermediate range spin-spin, spin-monopole and spin-cosmos interactions.
description: 12 pages, 2 tables; Plenary talk presented in the 21st International Symposium on Spin Physics (Spin2014), 19 October 2014 - 24 October 2014, Peking University, Beijing, China; Based partly on arXiv:1411.0460, arXiv:1410.0126 and arXiv:0912.5057
พุทธศาสนากับบทบาทสตรีในสังคมพหุวัฒนธรรมสมัยราชวงศ์ถัง
Creators: name: ศิริวรรณ วรชัยยุทธ
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2021
Subjects: ราชวงศ์ถัง
สตรี
พุทธศาสนา
สังคมพหุวัฒนธรรม

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 21, 1, 298-329
Hybrid imploding scalar and ads spacetime
Creators: name: Roberts, Mark D.
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences
subject: 83C15

description: A solution to the massless scalar cosmological constant field equations is presented. The solution has imploding scalar and parts of anti-deSitter or deSitter spacetime as limiting cases. Some of the solutions properties are discussed however not much can be said because of the contrasting properties of imploding scalar and deSitter spacetimes.
description: size increased from 3 pages to 10 pages
Identification of a Lactate-Quinone Oxidoreductase in Staphylococcus aureus that is Essential for Virulence
Creators: name: Richardson, Anthony R.
name: Scott, Eric
name: Vitko, Nicholas P.
name: Perkowski, Ellen F.
name: Thurlow, Lance R.
name: Khatri, Dal
name: Spontak, Jeffrey S.
name: Fuller, James R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2011

description: Staphylococcus aureus is an important human pathogen commonly infecting nearly every host tissue. The ability of S. aureus to resist innate immunity is critical to its success as a pathogen, including its propensity to grow in the presence of host nitric oxide (NO·). Upon exogenous NO· exposure, S. aureus immediately excretes copious amounts of L-lactate to maintain redox balance. However, after prolonged NO·-exposure, S. aureus reassimilates L-lactate specifically and in this work, we identify the enzyme responsible for this L-lactate-consumption as a L-lactate-quinone oxidoreductase (Lqo, SACOL2623). Originally annotated as Mqo2 and thought to oxidize malate, we show that this enzyme exhibits no affinity for malate but reacts specifically with L-lactate (KM = ∼330 μM). In addition to its requirement for reassimilation of L-lactate during NO·-stress, Lqo is also critical to respiratory growth on L-lactate as a sole carbon source. Moreover, Δlqo mutants exhibit attenuation in a murine model of sepsis, particularly in their ability to cause myocarditis. Interestingly, this cardiac-specific attenuation is completely abrogated in mice unable to synthesize inflammatory NO· (iNOS−/−). We demonstrate that S. aureus NO·-resistance is highly dependent on the availability of a glycolytic carbon sources. However, S. aureus can utilize the combination of peptides and L-lactate as carbon sources during NO·-stress in an Lqo-dependent fashion. Murine cardiac tissue has markedly high levels of L-lactate in comparison to renal or hepatic tissue consistent with the NO·-dependent requirement for Lqo in S. aureus myocarditis. Thus, Lqo provides S. aureus with yet another means of replicating in the presence of host NO·.
Reliable Initialization of GPU-enabled Parallel Stochastic Simulations Using Mersenne Twister for Graphics Processors
Creators: name: Passerat-Palmbach, Jonathan
name: Mazel, Claude
name: Mahul, Antoine
name: Hill, David
Publisher: name: arXiv
Year: 2015
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: FOS: Computer and information sciences

description: Parallel stochastic simulations tend to exploit more and more computing power and they are now also developed for General Purpose Graphics Process Units (GP-GPUs). Conse-quently, they need reliable random sources to feed their applications. We propose a survey of the current Pseudo Random Numbers Generators (PRNG) available on GPU. We give a particular focus to the recent Mersenne Twister for Graphics Processors (MTGP) that has just been released. Our work provides empirically checked statuses designed to initialize a particular configuration of this generator, in order to prevent any potential bias introduced by the parallelization of the PRNG.
Evaluation of photocatalytic processes in aqueous environments and on dry surfaces using titanium dioxide for bacterial inactivation
Creators: name: Clemente, Andrea
Publisher: name: Loughborough University
Year: 2019
Subjects: subject: 90499 Chemical Engineering not elsewhere classified
subject: FOS: Chemical engineering

description: In the present study, TiO2 photocatalysis has been investigated for the inactivation of pathogenic bacteria Escherichia coli ATCC 11303, Staphylococcus aureus SH1000 wild type, SH1000 ahpC/katA catalase mutant strains and SH1000 sodA/sodM superoxide dismutase mutant strains. The same dose of UVA light given at different light intensities resulted in different intracellular oxidative stress and bacteria inactivation kinetics especially for bacteria in presence of TiO2 coatings. The inactivation results obtained did not follow the Bunsen–Roscoe reciprocity law which is applicable for simple photochemical processes. Differences were observed in the intracellular response and subsequent killing of S. aureus upon exposure to UVA and these were found to be dependent on the level of intensity of irradiation and not the total UVA dose. [Continues.]
Shiga toxin 2-induced intestinal pathology in infant rabbits is A-subunit dependent and responsive to the tyrosine kinase and potential ZAK inhibitor imatinib
Creators: name: Kane, Anne V.
name: Vozenilek, Aimee
name: Rogers, Arlin B.
name: Ahluwalia, Amrita
name: Obata, Fumiko
name: Jandhyala, Dakshina M.
name: Thorpe, Cheleste M.
name: Magun, Bruce E.
name: Stone, Samuel M.
name: Kolling, Glynis L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Shiga toxin producing Escherichia coli (STEC) are a major cause of food-borne illness worldwide. However, a consensus regarding the role Shiga toxins play in the onset of diarrhea and hemorrhagic colitis (HC) is lacking. One of the obstacles to understanding the role of Shiga toxins to STEC-mediated intestinal pathology is a deficit in small animal models that perfectly mimic human disease. Infant rabbits have been previously used to study STEC and/or Shiga toxin-mediated intestinal inflammation and diarrhea. We demonstrate using infant rabbits that Shiga toxin-mediated intestinal damage requires A-subunit activity, and like the human colon, that of the infant rabbit expresses the Shiga toxin receptor Gb3. We also demonstrate that Shiga toxin treatment of the infant rabbit results in apoptosis and activation of p38 within colonic tissues. Finally we demonstrate that the infant rabbit model may be used to test candidate therapeutics against Shiga toxin-mediated intestinal damage. While the p38 inhibitor SB203580 and the ZAK inhibitor DHP-2 were ineffective at preventing Shiga toxin-mediated damage to the colon, pretreatment of infant rabbits with the drug imatinib resulted in a decrease of Shiga toxin-mediated heterophil infiltration of the colon. Therefore, we propose that this model may be useful in elucidating mechanisms by which Shiga toxins could contribute to intestinal damage in the human.
Mind Wandering & Perceptual Load
Creators: name: Steindorf, Lena
name: Pink, Sebastian
name: Rummel, Jan
Publisher: name: Open Science Framework
Year: 2021
Subjects: subject: Psychology
subject: FOS: Psychology
subject: Social and Behavioral Sciences

description: We are about to start running a study that examines the effect of perceptual (visual and auditory) load on mind wandering. In this registration, we preregister our main research questions as well as methods and intended analyses.
กรอบความคิดเกี่ยวกับ “ไทย” ที่นำเสนอผ่านกลวิธีทางภาษาในหนังสือพิมพ์รัสเซีย: กรณีศึกษา “Izvestia” และ “Komsomolskaya Pravda”
Creators: name: ปริตต์ อรุณโอษฐ์
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2021
Subjects: ไทย
กลวิธีทางภาษา
วาทกรรมวิเคราะห์เชิงวิพากษ์
หนังสือพิมพ์รัสเซีย

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 21, 1, 330-362
Update to Sleep, Stress and Aggression: A Meta-Analysis
Creators: name: , Olivia
name: Grainger, Sarah
name: McKay, Kate T
name: Henry, Julie
Publisher: name: Open Science Framework
Year: 2021
Subjects: subject: Health Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: This document contains an update to the inclusion criteria to supplement the initial preregistration, associated with the project “Sleep, Stress and Aggression: A Meta-Analysis’ which was registered on the Open Science Framework on 04/12/2020.
การศึกษาภูมิปัญญาท้องถิ่นผู้สูงอายุ คุณค่าและความท้าทาย ในสังคมเมืองยุคสมัยใหม่: กรณีศึกษาตำบลบางรักน้อย จังหวัดนนทบุรี
Creators: name: ธีรพัฒน์ วงศ์คุ้มสิน
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2021
Subjects: ภูมิปัญญาท้องถิ่น
คุณค่า
สังคมเมืองยุคใหม่
ผู้สูงอายุ

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 21, 1, 363-395
title: Zwischen Vollständigkeitsfalle und Kompetenzorientierung – Scaffolding für die Studiengangsgestaltung
Creators: name: Selmayr, Anna
Publisher: name: Zentrum für Hochschul- und Wissenschaftsdidaktik, Universität Regensburg
Year: 2022

description: Wie können Studiengänge konzipiert werden, ohne in die Vollständigkeitsfalle zu tappen? Anna Selmayr zeigt auf, wie eine Kompetenzmatrix helfen kann, die Inhalte anhand der Lernziele und Aneignungsformen zu einem kohärenten Studiengang zu bündeln.
คำเรียกผีภาษาล้านนา: การดำรงอยู่และโลกทัศน์ของชาวล้านนา
Creators: name: ศราวุธ หล่อดี
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2021
Subjects: คำเรียกผี
ภาษาล้านนา
การดำรงอยู่
โลกทัศน์
ภาคเหนือ

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 21, 1, 369-420
The information-complete quantum theory
Creators: name: Chen, Zeng-Bing
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum mechanics is a cornerstone of our current understanding of nature and extremely successful in describing physics covering a huge range of scales. However, its interpretation remains controversial since the early days of quantum mechanics. What does a quantum state really mean? Is there any way out of the so-called quantum measurement problem? Here we present an information-complete quantum theory (ICQT) and the trinary property of nature to beat the above problems. We assume that a quantum system's state provides an information-complete description of the system in the trinary picture. We give a consistent formalism of quantum theory that makes the information-completeness explicitly and argue that conventional quantum mechanics is an approximation of the ICQT. We then show how our ICQT provides a coherent picture and fresh angle of some existing problems in physics. The computational content of our theory is uncovered by defining an information-complete quantum computer.
description: 12 pages+1 figure; updated version; comments are welcome
Functions of Protein Arginine Methyltransferase 5 in Skeletal Muscle Development and Homeostasis
Creators: name: Kim, Kun Ho
Publisher: name: Purdue University Graduate School
Year: 2023
Subjects: classificationCode: 310103
subject: Cell metabolism
classificationCode: 310111
subject: Signal transduction
classificationCode: 310199
subject: Biochemistry and cell biology not elsewhere classified

description: We have provided the significance of Protein Methyltransferase 5 on skeletal muscle function and muscle development.
Toll-like receptor sensing of human herpesvirus infection
Creators: name: Damania, Blossom
name: Gregory, Sean M.
name: West, John A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Toll-like receptors (TLRs) are evolutionarily conserved pathogen sensors that constitute the first line of defense in the human immune system. Herpesviruses are prevalent throughout the world and cause significant disease in the human population. Sensing of herpesviruses via TLRs has only been documented in the last 10 years and our understanding of the relationship between these sentinels of the immune system and herpesvirus infection has already provided great insight into how the host cell responds to viral infection. This report will summarize the activation and modulation of TLR signaling in the context of human herpesvirus infections.
Toward a molecular pathogenic pathway for Yersinia pestis YopM
Creators: name: Kaplan, Alan M.
name: Uittenbogaard, Annette M.
name: Straley, Susan C.
name: Ye, Zhan
name: Gorman, Amanda A.
name: Cohen, Donald A.
name: Brickey, W. June
name: Ting, Jenny P.-Y.
name: Myers-Morales, Tanya
name: Chelvarajan, R. Lakshman
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: YopM is one of the six “effector Yops” of the human-pathogenic Yersinia, but its mechanism has not been defined. After delivery to J774A.1 monocyte-like cells, YopM can rapidly bind and activate the serine/threonine kinases RSK1 and PRK2. However, in infected mice, effects of Y. pestis YopM have been seen only after 24–48 h post-infection (p.i.). To identify potential direct effects of YopM in-vivo we tested for effects of YopM at 1 h and 16–18 h p.i. in mice infected systemically with 106 bacteria. At 16 h p.i., there was a robust host response to both parent and ΔyopM-1 Y. pestis KIM5. Compared to cells from non-infected mice, CD11b+ cells from spleens of infected mice produced more than 100-fold greater IFNγ. In the corresponding sera there were more than 100-fold greater amounts of IFNγ, G-CSF, and CXCL9, as well as more than 10-fold greater amounts of IL-6, CXCL10, and CXCL1. The only YopM-related differences were slightly lower CXCL10 and IL-6 in sera from mice infected 16 h with parent compared to ΔyopM-1 Y. pestis. Microarray analysis of the CD11b+ cells did not identify consistent transcriptional differences of ≥4-fold at 18 h p.i. However, at 1 h p.i. mRNA for early growth response transcription factor 1 (Egr1) was decreased when YopM was present. Bone marrow-derived macrophages infected for 1 h also expressed lower Egr1 message when YopM was present. Infected J774A.1 cells showed greater expression of Egr1 at 1 h p.i. when YopM was present, but this pattern reversed at 3 h. At 6 h p.i., Cxcl10 mRNA was lower in parent-strain infected cells. We conclude that decreased Egr1 expression is a very early transcriptional effect of YopM and speculate that a pathway may exist from RSK1 through Egr1. These studies revealed novel early transcriptional effects of YopM but point to a time after 18 h of infection when critical transitional events lead to later major effects on cytokine gene transcription.
Developing a Double Major Curriculum in Two Foreign Languages to Meet the Current Needs of Program Stakeholders
Creators: name: Sunporn Eiammongkhonsakun
Publisher: name: คณะศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์
Year: 2021
Subjects: Double major curriculum
foreign languages program
stakeholder

description: วารสารศิลปศาสตร์ มหาวิทยาลัยธรรมศาสตร์, 21, 1, 421-439
Testing the Efficacy of Two Antibiotics, (Tetracycline and Amoxicillin) on Bacteria Isolated from the Intestine of Wild African Catfish (Clarias Gariepinus Burchell, 1822) from Ajiwa Reservoir, Katsina State, Nigeria
Creators: name: Life Sciences: an International Journal (LSIJ)
Publisher: name: Zenodo
Year: 2025
Subjects: Antibiotic resistance
Bacteria isolation
Tetracycline
Amoxicillin
Clarias gariepinus

description: Antibiotics are powerful medicines that fight certain infections. However, illegal dumping of human andlivestock wastes into water bodies has severe consequences, including the development of antibioticresistant bacteria. This study isolated and identified bacteria from the intestine of wild Clarias gariepinus(African catfish) from the Ajiwa reservoir. Nine fish samples (W1-W9) yielded five different bacteriaspecies: Pseudomonas aeruginosa, Escherichia coli, Cytrobacter freundii, Acinetobacter baumannii, andKlebsiella pneumoniae. Antibiotic effectiveness was determined using Kirby-Bauer disc diffusion. Allisolated bacteria showed 100% effectiveness to Tetracycline, except one Pseudomonas spp (W3), whichshowed 13.5% effectiveness. However, all isolates were 100% resistant to Amoxicillin. These resultssuggest that Tetracycline has minimal interference, while Amoxicillin has abundant resistance. Theintroduction of multi-antibiotic-resistant bacteria from terrestrial environments poses a significant threatto aquatic ecosystems and human health.
description: Antibiotics are powerful medicines that fight certain infections. However, illegal dumping of human andlivestock wastes into water bodies has severe consequences, including the development of antibioticresistant bacteria. This study isolated and identified bacteria from the intestine of wild Clarias gariepinus(African catfish) from the Ajiwa reservoir. Nine fish samples (W1-W9) yielded five different bacteriaspecies: Pseudomonas aeruginosa, Escherichia coli, Cytrobacter freundii, Acinetobacter baumannii, andKlebsiella pneumoniae. Antibiotic effectiveness was determined using Kirby-Bauer disc diffusion. Allisolated bacteria showed 100% effectiveness to Tetracycline, except one Pseudomonas spp (W3), whichshowed 13.5% effectiveness. However, all isolates were 100% resistant to Amoxicillin. These resultssuggest that Tetracycline has minimal interference, while Amoxicillin has abundant resistance. Theintroduction of multi-antibiotic-resistant bacteria from terrestrial environments poses a significant threatto aquatic ecosystems and human health.
Milk- and solid-feeding practices and daycare attendance are associated with differences in bacterial diversity, predominant communities, and metabolic and immune function of the infant gut microbiome
Creators: name: Thompson, Amanda L.
name: Cadenas, Maria B.
name: Azcarate-Peril, M. A.
name: Monteagudo-Mera, Andrea
name: Lampl, Michelle L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The development of the infant intestinal microbiome in response to dietary and other exposures may shape long-term metabolic and immune function. We examined differences in the community structure and function of the intestinal microbiome between four feeding groups, exclusively breastfed infants before introduction of solid foods (EBF), non-exclusively breastfed infants before introduction of solid foods (non-EBF), EBF infants after introduction of solid foods (EBF+S), and non-EBF infants after introduction of solid foods (non-EBF+S), and tested whether out-of-home daycare attendance was associated with differences in relative abundance of gut bacteria. Bacterial 16S rRNA amplicon sequencing was performed on 49 stool samples collected longitudinally from a cohort of 9 infants (5 male, 4 female). PICRUSt metabolic inference analysis was used to identify metabolic impacts of feeding practices on the infant gut microbiome. Sequencing data identified significant differences across groups defined by feeding and daycare attendance. Non-EBF and daycare-attending infants had higher diversity and species richness than EBF and non-daycare attending infants. The gut microbiome of EBF infants showed increased proportions of Bifidobacterium and lower abundance of Bacteroidetes and Clostridiales than non-EBF infants. PICRUSt analysis indicated that introduction of solid foods had a marginal impact on the microbiome of EBF infants (24 enzymes overrepresented in EBF+S infants). In contrast, over 200 bacterial gene categories were overrepresented in non-EBF+S compared to non-EBF infants including several bacterial methyl-accepting chemotaxis proteins (MCP) involved in signal transduction. The identified differences between EBF and non-EBF infants suggest that breast milk may provide the gut microbiome with a greater plasticity (despite having a lower phylogenetic diversity) that eases the transition into solid foods.
Human performance consequences of automated decision aids: The impact of time pressure
Creators: name: Rieger, Tobias
name: Manzey, Dietrich
Publisher: name: Technische Universität Berlin
Year: 2020
Subjects: subject: 300 Sozialwissenschaften
subject: compliance and reliance
subject: human–automation interaction
subject: trust in automation
subject: warning compliance
subject: decision making
subject: visual search
subject: signal detection theory
subject: stress

description: Objective The study addresses the impact of time pressure on human interactions with automated decision support systems (DSSs) and related performance consequences. Background When humans interact with DSSs, this often results in worse performance than could be expected from the automation alone. Previous research has suggested that time pressure might make a difference by leading humans to rely more on a DSS. Method In two laboratory experiments, participants performed a luggage screening task either manually, supported by a highly reliable DSS, or by a low reliable DSS. Time provided for inspecting the X-rays was 4.5 s versus 9 s varied within-subjects as the time pressure manipulation. Participants in the automation conditions were either shown the automation’s advice prior (Experiment 1) or following (Experiment 2) their own inspection, before they made their final decision. Results In Experiment 1, time pressure compromised performance independent of whether the task was performed manually or with automation support. In Experiment 2, the negative impact of time pressure was only found in the manual but not in the two automation conditions. However, neither experiment revealed any positive impact of time pressure on overall performance, and the joint performance of human and automation was mostly worse than the performance of the automation alone. Conclusion Time pressure compromises the quality of decision-making. Providing a DSS can reduce this effect, but only if the automation’s advice follows the assessment of the human. Application The study provides suggestions for the effective implementation of DSSs in addition to supporting concerns that highly reliable DSSs are not used optimally by human operators.
Quantifying biometrology operator data analysis subjectivity within flow cytometry using measurement uncertainty principles
Creators: name: Grant, Rebecca
Publisher: name: Loughborough University
Year: 2019
Subjects: subject: 91399 Mechanical Engineering not elsewhere classified
subject: FOS: Mechanical engineering

description: A recent evaluation of medical error has shown it to be the third leading cause of death in the US, following heart disease and cancer. Better reporting and decision making could tackle this, but ultimately more accurate and precise measurement, with correct interpretation could make a significant difference to this unnecessary statistic. Clinical pathology measurement platforms are complex, requiring significant standardisation efforts to reduce false positives/negatives and the impacts these have on patient safety. Cell and Gene Therapy (CGT) manufacturing processes depend upon these platforms for measurement, with Flow Cytometry (FC) used for in-process and release metrics. However, the highly subjective nature of FC data analysis requires investigation to monitor impact on manufacturing and clinical decision making.
FC standardisation efforts have reduced variation from sample preparation and setup, however, no efforts have purely focused on the final post-analytical stage, to quantify the effect of subjective analysis of data files. This research has isolated this section of FC analysis, providing better measurement precision to build up a realistic uncertainty budget for FC measurements. Through a series of participant analysis studies that build in complexity, it has been shown that as FC data becomes more complex, the uncertainty contributions from inter-operator data analysis increase from 8 % to 34 %. This increase could mean the difference between a CGT treatment being provided at the right time, being discarded when it was suitable for administration, or an unsuitable treatment administered to the patient at an unsuitable time, having costly implications for all.
This variation does not correlate with operator experience or use frequency of the instrument, but is influenced by data visualisation effects, requiring further investigation at a later date to reduce this impact. Image parameters for other CGT measurement platforms are also impacted by subjective data analysis, requiring harmonisation to ensure the subjectivity is quantifiable, standardised and reduces manufacturing and hence medical error impacts to the patient and therapeutic product.
Digital quantum simulation of fermionic models with a superconducting circuit
Creators: name: Barends, R.
name: Lamata, L.
name: Kelly, J.
name: García-Álvarez, L.
name: Fowler, A. G.
name: Megrant, A.
name: Jeffrey, E.
name: White, T. C.
name: Sank, D.
name: Mutus, J. Y.
name: Campbell, B.
name: Chen, Yu
name: Chen, Z.
name: Chiaro, B.
name: Dunsworth, A.
name: Hoi, I. -C.
name: Neill, C.
name: O'Malley, P. J. J.
name: Quintana, C.
name: Roushan, P.
name: Vainsencher, A.
name: Wenner, J.
name: Solano, E.
name: Martinis, John M.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Simulating quantum physics with a device which itself is quantum mechanical, a notion Richard Feynman originated, would be an unparallelled computational resource. However, the universal quantum simulation of fermionic systems is daunting due to their particle statistics, and Feynman left as an open question whether it could be done, because of the need for non-local control. Here, we implement fermionic interactions with digital techniques in a superconducting circuit. Focusing on the Hubbard model, we perform time evolution with constant interactions as well as a dynamic phase transition with up to four fermionic modes encoded in four qubits. The implemented digital approach is universal and allows for the efficient simulation of fermions in arbitrary spatial dimensions. We use in excess of 300 single-qubit and two-qubit gates, and reach global fidelities which are limited by gate errors. This demonstration highlights the feasibility of the digital approach and opens a viable route towards analog-digital quantum simulation of interacting fermions and bosons in large-scale solid state systems.
description: Main text: 5 pages, 5 figures. Supplementary: 7 pages, 6 figures
The role of autophagy in intracellular pathogen nutrient acquisition
Creators: name: Kawula, Thomas
name: Brunton, Jason
name: Steele, Shaun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Following entry into host cells intracellular pathogens must simultaneously evade innate host defense mechanisms and acquire energy and anabolic substrates from the nutrient-limited intracellular environment. Most of the potential intracellular nutrient sources are stored within complex macromolecules that are not immediately accessible by intracellular pathogens. To obtain nutrients for proliferation, intracellular pathogens must compete with the host cell for newly-imported simple nutrients or degrade host nutrient storage structures into their constituent components (fatty acids, carbohydrates, and amino acids). It is becoming increasingly evident that intracellular pathogens have evolved a wide variety of strategies to accomplish this task. One recurrent microbial strategy is to exploit host degradative processes that break down host macromolecules into simple nutrients that the microbe can use. Herein we focus on how a subset of bacterial, viral, and eukaryotic pathogens leverage the host process of autophagy to acquire nutrients that support their growth within infected cells.