cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
(4041) Isabella Davidson
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
DESCRIPTION OF 2 NEW SPECIES OF MARINE BATILLIPEDIDAE, BATILLIPES-MARCELLI AND BATILLIPES-AFRICANUS (TARDIGRADA, HETEROTARDIGRADA)
Creators: name: Delucia, R. M. M.
name: Gallo, M. D.
name: Dezio, S. G.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1988

Abstract
title: Evaluating the inter tester reliability of the MRI WORMS system for chondral degradation in two anterior cruciate ligament reconstruction techniques.
Creators: name: Hodgkinson, James
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Musculoskeletal joint
subject: Musculoskeletal bone
subject: Musculoskeletal soft tissue
subject: MR
subject: Surgery
subject: Outcomes analysis
subject: Athletic injuries
subject: Trauma
subject: Inflammation

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: The anterior cruciate ligament (ACL) is the primary structure that provides knee joint stability. The function of the ACL is to limit excessive anterior displacement during movement. Thus, an ACL rupture can lead to instability, dysfunctional...
The Werner Syndrome Protein Binds Replication Fork and Holliday Junction DNAs as an Oligomer
Creators: name: Loeb, Lawrence A.
name: Tolun, Gökhan
name: Compton, Sarah A.
name: Kamath-Loeb, Ashwini S.
name: Griffith, Jack D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Werner syndrome is an inherited disease displaying a premature aging phenotype. The gene mutated in Werner syndrome encodes both a 3′ → 5′ DNA helicase and a 3′ → 5′ DNA exonuclease. Both WRN helicase and exonuclease preferentially utilize DNA substrates containing alternate secondary structures. By virtue of its ability to resolve such DNA structures, WRN is postulated to prevent the stalling and collapse of replication forks that encounter damaged DNA. Using electron microscopy, we visualized the binding of full-length WRN to DNA templates containing replication forks and Holliday junctions, intermediates observed during DNA replication and recombination, respectively. We show that both wild-type WRN and a helicase-defective mutant bind with exceptionally high specificity (>1000-fold) to DNA secondary structures at the replication fork and at Holliday junctions. Little or no binding is observed elsewhere on the DNA molecules. Calculations of the molecular weight of full-length WRN revealed that, in solution, WRN exists predominantly as a dimer. However, WRN bound to DNA is larger; the mass is consistent with that of a tetramer.
Unique D Box and KEN Box Sequences Limit Ubiquitination of Acm1 and Promote Pseudosubstrate Inhibition of the Anaphase-promoting Complex
Creators: name: Dial, J. Michael
name: Choi, Eunyoung
name: Hall, Mark C.
name: Jeong, Dah Eun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The anaphase-promoting complex (APC) regulates cell division in eukaryotes by targeting specific proteins for destruction. APC substrates generally contain one or more short degron sequences that help mediate their recognition and poly-ubiquitination by the APC. The most common and well characterized degrons are the destruction box (D box) and the KEN box. The budding yeast Acm1 protein, an inhibitor of Cdh1-activated APC (APCCdh1) also contains several conserved D and KEN boxes, and here we report that two of these located in the central region of Acm1 constitute a pseudosubstrate sequence required for APCCdh1 inhibition. Acm1 interacted with and inhibited substrate binding to the WD40 repeat domain of Cdh1. Combined mutation of the central D and KEN boxes strongly reduced both binding to the Cdh1 WD40 domain and APCCdh1 inhibition. Despite this, the double mutant, but not wild-type Acm1, was poly-ubiquitinated by APCCdh1in vitro. Thus, unlike substrates in which D and KEN boxes promote ubiquitination, these same elements in the central region of Acm1 prevent ubiquitination. We propose that this unique property of the Acm1 degron sequences results from an unusually high affinity interaction with the substrate receptor site on the WD40 domain of Cdh1 that may serve both to promote APC inhibition and protect Acm1 from destruction.
Food composition and feeding habits of little tunny, Euthynnus alletteratus (Rafinesque, 1810), from the Tunisian Mediterranean coasts
Creators: name: HAJJEJ, Ghailen
name: SLEY, Ayda
name: CHERIF, Mourad
name: JARBOUI, Othman
name: HATTOUR, Abdallah
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2016

description: The stomach contents of 622 little tunny Euthynnus alletteratus, sampled between January 2008 and December 2009, were examined. Fish size ranged from 19.2 to 97.8 cm fork length, and all fish were captured in the coastal areas of Tunisian waters. Among 622 stomachs examined, 287 were empty (%VI = 46.14). There were no significant variations in the vacuity index (%VI) depending on sex. After the stomach contents analysis, 22 prey taxa belonging to 14 families were identified: 15 fish species, 3 crustaceans, 3 mollusks and 1 vegetal species (Posidonia oceanica). This study was based mainly on the evolution of the index of relative importance (IRI) with respect to sex, fish size and season. Little tunny are carnivorous fish that feed opportunistically. Teleosts were found in the majority of stomachs, with a total relative importance (%IRI) of 97.3% and Sardinella aurita was the most important prey species (%IRI = 17.56) followed by Boops boops (%IRI = 0.87) and Sardina pilchardus (%IRI = 0.77). All other prey (crustaceans and molluscs) are secondary or incidental.
Biological characteristics of three Brachyuran crab species in the Lagoon of Elbibane, South-Eastern Tunisia
Creators: name: JOUILI, Soufiane
name: ARCULEO, Marco
name: MANSOUR, Lamjed
name: RABAOUI, Lotfi
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 2016

description: This study is a first contribution to the knowledge of the biology of three crab species, Carcinus aestuarii, Eriphia verrucosa and Pachygrapsus marmoratus, occurring in the intertidal zone of Elbibane lagoon, south-eastern Tunisia. A total of 1264 individuals from the three brachyuran species were collected monthly from April 2010 until March 2011 and their reproduction and growth parameters were determined. The seasonal distribution of carapace width showed for the three species that males have always a greater size than females. The length-weight relationship showed in the three species a negative allometry in males, and in non-ovigerous females. The von Bertalanffy growth model (VBGF) parameters for C. aestuarii females and males were: CL∞ = 49.35 mm, K = 0.87 year-1 and CL∞ = 55.70 mm, K = 0.75 year-1, respectively, whereas in females and males of P. marmoratus, the parameters were CL∞ = 42.95 mm, K = 0.56 year-1 and CL∞ = 44.08 mm, K = 0.52 respectively. In E. verrucosa, it was possible to estimate only the parameters in females (CL∞ = 73.50 mm, K = 0.66 year-1). In all, the VBGF values indicate that the crabs are fast-growing species, with a fishable lifespan of 3-4 years identified by Bhattacharya's method. Moreover, the sex-ratio of the three decapods was found to be male-biased along most of the year; the abundance of females appeared to increase in reproduction periods. In addition, the fecundity of the three species was found to be correlated with body size and weight.
Additional file 2 of “There is no joy in the family anymore”: a mixed-methods study on the experience and impact of maternal mortality on families in Ghana
Creators: name: Lawrence, Emma R.
name: Appiah-Kubi, Adu
name: Lawrence, Hannah R.
name: Lui, Maxine Y.
name: Owusu-Antwi, Ruth
name: Konney, Thomas
name: Moyer, Cheryl A.
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 2. Linear regression analyses evaluating predictors of complicated grief following maternal death.
title: Stereotactic body radiotherapy with CyberKnife for treatment of hepatocellular carcinoma: Tertiary Liver Transplant Unit Experience
Creators: name: Tan, Hendrick
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Multidisciplinary cancer care
subject: Image guided radiotherapy
subject: Stereotactic radiotherapy
subject: Radiation therapy / Oncology
subject: MR
subject: Abdomen
subject: Liver
subject: Oncology

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Stereotactic body radiotherapy (SBRT) is an emerging non-invasive treatment modality for treatment of hepatocellular carcinoma (HCC) when curative treatments cannot be applied. It allows ablative doses to be delivered safely to the focal...
ENHANCING ESP STUDENTS' PROFESSIONAL COMPETENCE IN TEACHING ENGLISH
Creators: name: Bakhronova, Mahliyo
Publisher: name: Zenodo
Year: 2025

description: In today's globalized world, the demand for professionally competent English teachers, particularly those specializing in English for Specific Purposes (ESP), has significantly increased. This article explores effective strategies for enhancing ESP students' professional competence in teaching English. It discusses the integration of subject-specific knowledge, pedagogical skills, and practical training to equip future ESP instructors with the necessary expertise. The study highlights the role of innovative teaching methodologies, technology-assisted learning, and experiential practices such as case studies, simulations, and internships. Additionally, it emphasizes the importance of continuous professional development, reflective teaching, and collaboration with industry professionals to align ESP instruction with real-world needs. By adopting a comprehensive approach to training, ESP students can develop the linguistic, methodological, and intercultural competencies required for effective English teaching in specialized fields. The findings contribute to the ongoing discourse on teacher education, offering insights into best practices for preparing ESP educators to meet the evolving demands of their profession.
Observation of surface states on heavily indium doped SnTe(111), a superconducting topological crystalline insulator
Creators: name: Polley, C. M.
name: Jovic, V.
name: Su, T. -Y.
name: Saghir, M.
name: Newby, D.
name: Kowalski, B.
name: Jakiela, R.
name: Barcz, A.
name: Guziewicz, M.
name: Balasubramanian, T.
name: Balakrishnan, G.
name: Laverock, J.
name: Smith, K. E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The topological crystalline insulator tin telluride is known to host superconductivity when doped with indium (Sn$_{1-x}$In$_{x}$Te), and for low indium contents ($x=0.04$) it is known that the topological surface states are preserved. Here we present the growth, characterization and angle resolved photoemission spectroscopy analysis of samples with much heavier In doping (up to $x\approx0.4$), a regime where the superconducting temperature is increased nearly fourfold. We demonstrate that despite strong p-type doping, Dirac-like surface states persist.
β-Catenin Levels Influence Rapid Mechanical Responses in Osteoblasts
Creators: name: Ma, Meiyun
name: Gross, Ted S.
name: Xie, Zhihui
name: Sen, Buer
name: Rubin, Janet
name: Case, Natasha
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Mechanical loading of bone initiates an anabolic, anticatabolic pattern of response, yet the molecular events involved in mechanical signal transduction are not well understood. Wnt/β-catenin signaling has been recognized in promoting bone anabolism, and application of strain has been shown to induce β-catenin activation. In this work, we have used a preosteoblastic cell line to study the effects of dynamic mechanical strain on β-catenin signaling. We found that mechanical strain caused a rapid, transient accumulation of active β-catenin in the cytoplasm and its translocation to the nucleus. This was followed by up-regulation of the Wnt/β-catenin target genes Wisp1 and Cox2, with peak responses at 4 and 1 h of strain, respectively. The increase of β-catenin was temporally related to the activation of Akt and subsequent inactivation of GSK3β, and caveolin-1 was not required for these molecular events. Application of Dkk-1, which disrupts canonical Wnt/LRP5 signaling, did not block strain-induced nuclear translocation of β-catenin or up-regulation of Wisp1 and Cox2 expression. Conditions that increased basal β-catenin levels, such as lithium chloride treatment or repression of caveolin-1 expression, were shown to enhance the effects of strain. In summary, mechanical strain activates Akt and inactivates GSK3β to allow β-catenin translocation, and Wnt signaling through LRP5 is not required for these strain-mediated responses. Thus, β-catenin serves as both a modulator and effector of mechanical signals in bone cells.
title: Audit of ureteric calculi measurements in patients who undergo CT KUB
Creators: name: Lee, Kirsti So Ve
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Obstruction / Occlusion
subject: Education
subject: Audit and standards
subject: CT
subject: Urinary Tract / Bladder
subject: Calcifications / Calculi

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Information regarding calculus location, size as well as complications of hydronephrosis and perinephric collection/abscess are essential for determining the management pathway in patients with renal tract calculi. This information is required for...
(4036) James Brady
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Early evolution of embedded clusters
Creators: name: Dale, J. E.
name: Ercolano, B.
name: Bonnell, I. A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: We examine the combined effects of winds and photoionizing radiation from O--type stars on embedded stellar clusters formed in model turbulent molecular clouds covering a range of masses and radii. We find that feedback is able to increase the quantities of dense gas present, but decreases the rate and efficiency of the conversion of gas to stars relative to control simulations in which feedback is absent. Star formation in these calculations often proceeds at a rate substantially slower than the freefall rate in the dense gas. This decoupling is due to the weakening of, and expulsion of gas from, the deepest parts of the clouds' potential wells where most of the star formation occurs in the control simulations. This results in large fractions of the stellar populations in the feedback simulation becoming dissociated from dense gas. However, where star formation \emph{does} occur in both control and feedback simulations, it does so in dense gas, so the correlation between star formation activity and dense gas is preserved. The overall dynamical effects of feedback on the \emph{clusters} are minimal, with only small fraction of stars becoming unbound, despite large quantities of gas being expelled from some clouds. This owes to the settling of the stars into virialised and stellar--dominated configurations before the onset of feedback. By contrast, the effects of feedback on the observable properties of the clusters -- their U--, B-- and V--band magnitudes -- are strong and sudden. The timescales on which the clusters become visible and unobscured are short compared with the timescales which the clouds are actually destroyed.
description: 19 pages, 17 figures (many degraded to get below submission size limit), accepted by MNRAS
Aberrant Receptor Internalization and Enhanced FRS2-dependent Signaling Contribute to the Transforming Activity of the Fibroblast Growth Factor Receptor 2 IIIb C3 Isoform
Creators: name: Harden, T. Kendall
name: Der, Channing J.
name: Cha, Jiyoung Y.
name: Maddileti, Savitri
name: Mitin, Natalia
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Alternative splice variants of fibroblast growth factor receptor 2 (FGFR2) IIIb, designated C1, C2, and C3, possess progressive reduction in their cytoplasmic carboxyl termini (822, 788, and 769 residues, respectively), with preferential expression of the C2 and C3 isoforms in human cancers. We determined that the progressive deletion of carboxyl-terminal sequences correlated with increasing transforming potency. The highly transforming C3 variant lacks five tyrosine residues present in C1, and we determined that the loss of Tyr-770 alone enhanced FGFR2 IIIb C1 transforming activity. Because Tyr-770 may compose a putative YXXL sorting motif, we hypothesized that loss of Tyr-770 in the 770YXXL motif may cause disruption of FGFR2 IIIb C1 internalization and enhance transforming activity. Surprisingly, we found that mutation of Leu-773 but not Tyr-770 impaired receptor internalization and increased receptor stability and activation. Interestingly, concurrent mutations of Tyr-770 and Leu-773 caused 2-fold higher transforming activity than caused by the Y770F or L773A single mutations, suggesting loss of Tyr and Leu residues of the 770YXXL773 motif enhances FGFR2 IIIb transforming activity by distinct mechanisms. We also determined that loss of Tyr-770 caused persistent activation of FRS2 by enhancing FRS2 binding to FGFR2 IIIb. Furthermore, we found that FRS2 binding to FGFR2 IIIb is required for increased FRS2 tyrosine phosphorylation and enhanced transforming activity by Y770F mutation. Our data support a dual mechanism where deletion of the 770YXXL773 motif promotes FGFR2 IIIb C3 transforming activity by causing aberrant receptor recycling and stability and persistent FRS2-dependent signaling.
Can A Pseudo-Nambu-Goldstone Higgs Lead To Symmetry Non-Restoration?
Creators: name: Kilic, Can
name: Swaminathan, Sivaramakrishnan
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: The calculation of finite temperature contributions to the scalar potential in a quantum field theory is similar to the calculation of loop corrections at zero temperature. In natural extensions of the Standard Model where loop corrections to the Higgs potential cancel between Standard Model degrees of freedom and their symmetry partners, it is interesting to contemplate whether finite temperature corrections also cancel, raising the question of whether a broken phase of electroweak symmetry may persist at high temperature. It is well known that this does not happen in supersymmetric theories because the thermal contributions of bosons and fermions do not cancel each other. However, for theories with same spin partners, the answer is less obvious. Using the Twin Higgs model as a benchmark, we show that although thermal corrections do cancel at the level of quadratic divergences, subleading corrections still drive the system to a restored phase. We further argue that our conclusions generalize to other well-known extensions of the Standard Model where the Higgs is rendered natural by being the pseudo-Nambu-Goldstone mode of an approximate global symmetry.
description: 21 pages, 5 figures. v2: fixed problem related to references with 9-digit arXiv identifiers. v3: references added v4: Some clarifications and more references added; matches published version
Airway Epithelial Inflammation-induced Endoplasmic Reticulum Ca 2+ Store Expansion Is Mediated by X-box Binding Protein-1
Creators: name: Wolfgang, Matthew C.
name: Martino, Mary E.B.
name: Ribeiro, Carla M.P.
name: Fulcher, Nanette B.
name: O'Neal, Wanda K.
name: Olsen, John C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Inflamed cystic fibrosis (CF) human bronchial epithelia (HBE), or normal HBE exposed to supernatant from mucopurulent material (SMM) from CF airways, exhibit endoplasmic reticulum (ER)/Ca2+ store expansion and amplified Ca2+-mediated inflammation. HBE inflammation triggers an unfolded protein response (UPR) coupled to mRNA splicing of X-box binding protein-1 (XBP-1). Because spliced XBP-1 (XBP-1s) promotes ER expansion in other cellular models, we hypothesized that XBP-1s is responsible for the ER/Ca2+ store expansion in inflamed HBE. XBP-1s was increased in freshly isolated infected/inflamed CF in comparison with normal HBE. The link between airway epithelial inflammation, XBP-1s, and ER/Ca2+ store expansion was then addressed in murine airways challenged with phosphate-buffered saline or Pseudomonas aeruginosa. P. aeruginosa-challenged mice exhibited airway epithelial ER/Ca2+ store expansion, which correlated with airway inflammation. P. aeruginosa-induced airway inflammation triggered XBP-1s in ER stress-activated indicator (ERAI) mice. To evaluate the functional role of XBP-1s in airway inflammation linked to ER/Ca2+ store expansion, control, XBP-1s, or dominant negative XBP-1 (DN-XBP-1) stably expressing 16HBE14o- cell lines were used. Studies with cells transfected with an unfolded protein response element (UPRE) luciferase reporter plasmid confirmed that the UPRE was activated or inhibited by expression of XBP-1s or DN-XBP-1, respectively. Expression of XBP-1s induced ER/Ca2+ store expansion and potentiated bradykinin-increased interleukin (IL)-8 secretion, whereas expression of DN-XBP-1 inhibited bradykinin-dependent IL-8 secretion. In addition, expression of DN-XBP-1 blunted SMM-induced ER/Ca2+ store expansion and SMM-induced IL-8 secretion. These findings suggest that, in inflamed HBE, XBP-1s is responsible for the ER/Ca2+ store expansion that confers amplification of Ca2+-dependent inflammatory responses.
CONTRIBUTION A LA CONNAISSANCE DES GASTROTRICHES DES CÔTES DE TOSCANE
Creators: name: LUPORINI, Pierangelo
name: MAGAGNINI, Giampaolo
name: TONGIORGI, Paolo
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1971

description: Some species of Gastrotricha have been found along the Tuscan coast between Leghorn and Pisa: seven of these species are described in the present paper. Tetranchyroderma polypodium n.sp. is characterized by the presence of pentancres and of sixty adhesive tubules on each side of the body. Paraturbanella pallida n.sp. is distinguishable from the other species of the genus mainly for the number of its adhesive tubules which are 11 on ventral organs and 14-16 on each caudal lobe. The taxonomic position of one species of the subterranea group of the genus Xenotrichula is discussed. New morphological details and drawings are given for Tetranchyroderma papii Gerlach, Diplodasys minor Remane, Aspidiophorus mediterraneus Remane and Polymerurus tesselatus Renaud-Mornant.
Abundances in the atmosphere of the metal-rich planet-host star HD 77338
Creators: name: Kushniruk, I. O.
name: Pavlenko, Ya. V.
name: Jenkins, J. S.
name: Jones, H. R. A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Abundances of Fe, Si, Ni, Ti, Na, Mg, Cu, Zn, Mn, Cr and Ca in the atmosphere of the K-dwarf HD 77338 are determined and discussed. HD 77338 hosts a hot Uranus-like planet and is currently the most metal-rich single star to host any planet. Determination of abundances was carried out in the framework of a self-consistent approach developed by Pavlenko et al. (2012). Abundances were computed iteratively by the program ABEL8, and the process converged after 4 iterations. We find that most elements follow the iron abundance, however some of the iron peak elements are found to be over-abundant in this star.
Biphasic Activation of p38MAPK Suggests That Apoptosis Is a Downstream Event in Pemphigus Acantholysis
Creators: name: Lee, Hua En
name: Berkowitz, Paula
name: Jolly, Puneet S.
name: Chua, Michael P.
name: Diaz, Luis A.
name: Rubenstein, David S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: In pemphigus vulgaris and pemphigus foliaceus (PF), autoantibodies against desmoglein-3 and desmoglein-1 induce epidermal cell detachment (acantholysis) and blistering. Activation of keratinocyte intracellular signaling pathways is emerging as an important component of pemphigus IgG-mediated acantholysis. We previously reported activation of p38 mitogen-activated protein kinase (MAPK) in response to pathogenic pemphigus vulgaris and PF IgG. Inhibition of p38MAPK blocked pemphigus IgG-induced cytoskeletal reorganization in tissue culture and blistering in pemphigus mouse models. We now extend these observations by demonstrating two peaks of p38MAPK activation in pemphigus tissue culture and mouse models. Administration of the p38MAPK inhibitor SB202190 before PF IgG injection blocked both peaks of p38MAPK phosphorylation and blister formation, consistent with our previous findings; however, administration of the inhibitor 4 h after PF IgG injection blocked only the later peak of p38MAPK activation but failed to block blistering. Examination of the temporal relationship of p38MAPK phosphorylation and apoptosis showed that apoptosis occurs at or after the second peak of p38MAPK activation. The time course of p38MAPK activation and apoptotic markers, as well as the ability of inhibitors of p38MAPK to block activation of the proapoptotic proteinase caspase-3, suggest that activation of apoptosis is downstream to, and a consequence of, p38MAPK activation in pemphigus acantholysis. Furthermore, these observations suggest that the earlier peak of p38MAPK activation is part of the mechanism leading to acantholysis, whereas the later peak of p38MAPK and apoptosis may not be essential for acantholysis.
Mismatch in the Classification of Linear Subspaces: Sufficient Conditions for Reliable Classification
Creators: name: Sokolic, Jure
name: Renna, Francesco
name: Calderbank, Robert
name: Rodrigues, Miguel R. D.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Machine Learning (stat.ML)
subject: FOS: Computer and information sciences

description: This paper considers the classification of linear subspaces with mismatched classifiers. In particular, we assume a model where one observes signals in the presence of isotropic Gaussian noise and the distribution of the signals conditioned on a given class is Gaussian with a zero mean and a low-rank covariance matrix. We also assume that the classifier knows only a mismatched version of the parameters of input distribution in lieu of the true parameters. By constructing an asymptotic low-noise expansion of an upper bound to the error probability of such a mismatched classifier, we provide sufficient conditions for reliable classification in the low-noise regime that are able to sharply predict the absence of a classification error floor. Such conditions are a function of the geometry of the true signal distribution, the geometry of the mismatched signal distributions as well as the interplay between such geometries, namely, the principal angles and the overlap between the true and the mismatched signal subspaces. Numerical results demonstrate that our conditions for reliable classification can sharply predict the behavior of a mismatched classifier both with synthetic data and in a motion segmentation and a hand-written digit classification applications.
description: 17 pages, 7 figures, submitted to IEEE Transactions on Signal Processing
C Terminus of Hsc70-interacting Protein Promotes Smooth Muscle Cell Proliferation and Survival through Ubiquitin-mediated Degradation of FoxO1
Creators: name: Xie, Ping
name: Gu, Dongfeng
name: Li, Huihua
name: Fan, Yongna
name: Zhang, Hua
name: Zheng, Lianfang
name: Patterson, Cam
name: Li, Fang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Forkhead transcription factors (FoxOs) play a pivotal role in controlling cellular proliferation and survival. The cellular level of these factors is tightly regulated through the phosphoinositide 3-kinase/Akt and ubiquitin-mediated degradation. However, the ubiquitin ligases responsible for the degradation of FoxO1 and the relevance of this regulation to smooth muscle cell (SMC) proliferation and survival have not been fully identified. Here we showed that overexpression of C terminus of Hsc70-interacting protein (CHIP) promoted ubiquitination and degradation of FoxO1 in SMCs in response to tumor necrosis factor-α. Both the U-box (containing ubiquitin ligase activity) and the charged (essential for FoxO1 binding) domains within CHIP were required for CHIP-mediated FoxO1 down-regulation. Moreover, interaction and ubiquitination of FoxO1 by CHIP depended on phos pho ryl a tion of FoxO1 at Ser-256. Furthermore, overexpression of CHIP repressed FoxO1-mediated transactivation and its proapo pto tic function following tumor necrosis factor-α treatment. In contrast, knockdown of CHIP by small interfering RNA enhanced FoxO1-mediated transactivation and its effect on SMC proliferation and survival. Taken together, our data indicate that CHIP is a negative regulator of FoxO1 activity through ubiquitin-mediated degradation, and inhibition of CHIP may serve as a potential therapeutic target for reducing proliferative arterial diseases.
title: Internationale Hilfe während der Nordkoreanischen Hungersnot von 1994 bis 1998
Creators: name: Böttcher, Jennifer Rebecca
Year: 2022

description: Ziel dieser Masterarbeit ist es, die Formen internationaler Hilfe während der Nordkoreanischen Hungersnot von 1994 bis 1998 zu bestimmen, liberale und konservative Meinungen dazu in den südkoreanischen Zeitungen Chosun Ilbo und Hankyoreh zu finden und Unterschiede in der Berichterstattung aufzuzeigen. Durch die Qualitative Inhaltsanalyse nach Philipp Mayring konnte in den insgesamt 69 Zeitungsartikeln keine eindeutige Unterscheidung der Inhalte einer politischer Orientierung zugeordnet werden. In der Chosun Ilbo erschienen bis Februar 1997 mehr Artikel, als in der Hankyoreh, die erst ab März 1997 mehr Artikel über die Hungersnot und internationale Hilfe veröffentlichte. Die genannten Hilfsleistungen waren großteils thematisch gleich. Die Chosun Ilbo berichtete mehr über Hilfsleistungen der USA als die Hankyoreh; diese wiederum mehr über politische Faktoren und Schwierigkeiten Nordkoreas.
description: The aim of this master's thesis is to determine the forms of international aid during the North Korean famine from 1994 to 1998, to find liberal and conservative opinions on this in the South Korean newspapers Chosun Ilbo and Hankyoreh, and to show differences in reporting. Using Philipp Mayring’s Qualitative Content Analysis, no clear distinction of content could be assigned to a political orientation in the 69 analysed newspaper articles. More articles appeared in the Chosun Ilbo until February of 1997 than in the Hankyoreh, which did not publish more articles about the famine and international aid until March of 1997. The mentioned relief efforts were largely thematically the same. The Chosun Ilbo reported more on U.S. aid than the Hankyoreh; the Hankyoreh, in turn, reported more on North Korean political factors and difficulties the North Korean Regime was facing.
ÉTUDE PRÉLIMINAIRE, MORPHOLOGIQUE ET HISTOLOGIQUE, DE L'APPAREIL GÉNITAL MALE DE NEROPHIS LUMBRICIFORMIS (TÉLÉOSTÉENS SYNGNATHIDÉS)
Creators: name: GUYOMARC'H, J.-P.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1971

description: A detailed description of genital tract is given in male Nerophis: general morphology and description of germ cells different types. It precedes a particular study of somatical cells in order to define their structure and roll. Two morphological and functional different types are described.
Additional file 1 of Tau seeding activity in various regions of down syndrome brain assessed by two novel assays
Creators: name: Jin, Nana
name: Gu, Jianlan
name: Wu, Ruozhen
name: Chu, Dandan
name: Tung, Yunn Chyn
name: Wegiel, Jerzy
name: Wisniewski, Thomas
name: Gong, Cheng-Xin
name: Iqbal, Khalid
name: Liu, Fei
Publisher: name: figshare
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. Supplementary figures.
title: A pictorial review of benign and malignant subsolid pulmonary nodules on CT, and a review of current management
Creators: name: Zhao, Henry
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Lung
subject: Respiratory system
subject: Oncology
subject: CT
subject: Education
subject: Cancer

description: Learning objectives Background Imaging findings OR Procedure details Conclusion Personal information References
description: Learning objectives: To illustrate cases of subsolid pulmonary nodules on CT, and their outcome on follow-up (benign versus malignant) To review the current management of subsolid pulmonary...
(4037) James Kelly
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Hall detection of a ppm spin polarization
Creators: name: Hou, Dazhi
name: Qiu, Z.
name: Iguchi, R.
name: Sato, K.
name: Uchida, K.
name: Bauer, G. E. W.
name: Saitoh, E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Hall effects have been employed as sensitive detectors of magnetic fields and magnetizations. In spintronics, exotic phenomena often emerge from a non-equilibrium spin polarization or magnetization, that is very difficult to measure directly. The challenge is due to the tiny total moment, which is out of reach of superconducting quantum interference devices and vibrating sample magnetometers or spectroscopic methods such as X-ray magnetic circular dichroism. The Kerr effect is sufficiently sensitive only in direct gap semiconductors, in which the Kerr angle can be resonantly enhanced. Here we demonstrate that even one excess spin in a million can be detected by a Hall effect at room temperature. The novel Hall effect is not governed by the spin Hall conductivity but by its energy derivative thereby related to the spin Nernst effect.
Cerebral Cavernous Malformation 2 Protein Promotes Smad Ubiquitin Regulatory Factor 1-mediated RhoA Degradation in Endothelial Cells
Creators: name: Crose, Lisa E.S.
name: Sciaky, Noah
name: Hilder, Thomas L.
name: Johnson, Gary L.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Mutation of CCM2 predisposes individuals to cerebral cavernous malformations, vascular abnormalities that cause seizures and hemorrhagic stroke. CCM2 has been proposed to regulate the activity of RhoA for maintenance of vascular integrity. Herein, we define a novel mechanism where the CCM2 phosphotyrosine binding (PTB) domain binds the ubiquitin ligase (E3) Smurf1, controlling RhoA degradation. Brain endothelial cells with knockdown of CCM2 have increased RhoA protein and display impaired directed cell migration. CCM2 binding of Smurf1 increases Smurf1-mediated degradation of RhoA. CCM2 does not significantly alter the catalytic activity of Smurf1, nor is CCM2 a Smurf1 substrate. Rather the CCM2-Smurf1 interaction functions to localize Smurf1 for RhoA degradation. These findings provide a molecular mechanism for the pathogenesis of cerebral cavernous malformations (CCM) resulting from loss of CCM2-mediated localization of Smurf1, which controls RhoA degradation required for maintenance of normal endothelial cell physiology.
title: Sexuelle und geschlechtliche Vielfalt - (k)ein Thema in der stationären Langzeitpflege in Österreich
Creators: name: Obernauer, Eva
Year: 2023

description: Vor dem Hintergrund spezifischer Bedürfnisse von LSBTI* verfolgt die Forschungsarbeit das Ziel, Erkenntnisse bezüglich der Versorgungslage von LSBTI* im Setting der stationären Langzeitpflege (LZP) in Österreich zu generieren. Auf Basis eines qualitativen Forschungsdesigns wurden leitfadengestützte Interviews mit Führungskräften aus der Praxis erhoben, sowie Textbausteine von Webseiten von Pflegeeinrichtungen mittels Stichwortsuche ausgewählt. Die Daten wurden mit der qualitativen Inhaltsanalyse nach Mayring ausgewertet. Die Ergebnisse zeigen, dass Sensibilität gegenüber LSBTI* heterogen ausgeprägt ist. Es dominiert die Ansicht, dass LSBTI*-sensible Pflege ein Zukunftsthema sei. Daraus ergeben sich zwei divergierende Einschätzungen die Handlungsnotwendigkeit betreffend. Einerseits sprechen sich Verantwortliche dafür aus, vorbereitende Maßnahmen zu ergreifen, anderseits wird noch keine Notwendigkeit des Handelns erkannt, eine Handlungsbereitschaft aber antizipiert. Die Verankerung in der Unternehmenskultur bleibt eine Ausnahmeerscheinung. Auf Basis einer offenen Selbsteinschätzung verknüpft mit einer universalistischen Grundhaltung werden spezifische Bedürfnisse von LSBTI* häufig nicht erkannt und größtenteils vorherrschende Handlungsstrategien als ausreichend klassifiziert. Binäre Geschlechter- und Rollenvorstellungen, sowie heteronormativ gefasste Strukturen führen mitunter zu Otheringprozessen.
description: Due to the specific needs of LGBTI* individuals, this research aims to generate insights into the current situation of LGBTI* individuals in long-term care (LTC) facilities in Austria. Based on a qualitative research design, interviews with managers from the field and additionally a website analysis of LTCs based on key words, were conducted. The data was evaluated using the qualitative content analysis method according to Mayring. The results show that sensitivity towards LGBTI* individuals is heterogeneous. The dominant view observed is that LGBTI*-sensitive care is a concern for the future. The results show two different assessments of the need for action. On the one hand, managers are in favor of taking preparatory measures; on the other hand, no need for action is yet recognized but a willingness to act is anticipated. Implementation of LGBTI*-sensitive care in the corporate culture remains an exception. Based on the self-assessment of having an open attitude combined with a universalistic attitude, specific needs of LGBTI* individuals are often not recognized and prevailing action strategies are largely classified as sufficient. Concepts of a gender binary and gender role perception as well as heteronormative structures sometimes still lead to othering.
(4038) Grace Mccormick
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
title: Improvements in rectal dosimetry with introduction of SpaceOAR hydrogel spacer prior to definitive radiotherapy for prostate cancer
Creators: name: Kleiven, Hilde
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Oncology
subject: Genital / Reproductive system male
subject: CT
subject: Radiation therapy / Oncology
subject: Dosimetry
subject: Intensity Modulated Radiotherapy (IMRT)
subject: Dosimetric comparison

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: Biocompatible prostate-rectal spacers inserted in the perirectal space of patients with prostate cancer prior to receiving high-dose radiotherapy have been evaluated in several series and a large randomised controlled trial and found to be...
title: A comparison of the diagnostic accuracy of CT colonoscopy versus optical colonoscopy for clinically significant polyps in a tertiary hospital
Creators: name: Dassanayake, Yamal
Publisher: name: The Royal Australian and New Zealand College of Radiologists
Year: 2017
Subjects: subject: Colon
subject: Abdomen
subject: Gastrointestinal tract
subject: CT
subject: Colonography CT
subject: Cancer

description: Purpose Methods and materials Results Conclusion Personal information References
description: Purpose: CT colonoscopy has the advantages of having less complications, being cheaper, more accessible for regional areas, ability to assess beyond stenotic lesions, diagnosing nodal and metastatic disease and faster procedure time compared to optical...
Coordinated Activation of the Origin Licensing Factor CDC6 and CDK2 in Resting Human Fibroblasts Expressing SV40 Small T Antigen and Cyclin E
Creators: name: Kurimchak, Alison
name: Sotillo, Elena
name: Cook, Jeanette Gowen
name: Padgaonkar, Amol
name: Garriga, Judit
name: Graña, Xavier
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: We have previously shown that SV40 small t antigen (st) cooperates with deregulated cyclin E to activate CDK2 and bypass quiescence in normal human fibroblasts (NHF). Here we show that st expression in serum-starved and density-arrested NHF specifically induces up-regulation and loading of CDC6 onto chromatin. Coexpression of cyclin E results in further accumulation of CDC6 onto chromatin concomitantly with phosphorylation of CDK2 on Thr-160 and CDC6 on Ser-54. Investigation of the mechanism leading to CDC6 accumulation and chromatin loading indicates that st is a potent inducer of cdc6 mRNA expression and increases CDC6 protein stability. We also show that CDC6 expression in quiescent NHF efficiently promotes cyclin E loading onto chromatin, but it is not sufficient to activate CDK2. Moreover, we show that CDC6 expression is linked to phosphorylation of the activating T loop of CDK2 in serum-starved NHF stimulated with mitogens or ectopically expressing cyclin E and st. Our data suggest a model where the combination of st and deregulated cyclin E result in cooperative and coordinated activation of both an essential origin licensing factor, CDC6, and an activity required for origin firing, CDK2, resulting in progression from quiescence to S phase.
Opportunistic Scheduling for Full-Duplex Uplink-Downlink Networks
Creators: name: Karakus, Can
name: Diggavi, Suhas
Publisher: name: arXiv
Year: 2015
Subjects: subject: Information Theory (cs.IT)
subject: FOS: Computer and information sciences

description: We study opportunistic scheduling and the sum capacity of cellular networks with a full-duplex multi-antenna base station and a large number of single-antenna half-duplex users. Simultaneous uplink and downlink over the same band results in uplink-to-downlink interference, degrading performance. We present a simple opportunistic joint uplink-downlink scheduling algorithm that exploits multiuser diversity and treats interference as noise. We show that in homogeneous networks, our algorithm achieves the same sum capacity as what would have been achieved if there was no uplink-to-downlink interference, asymptotically in the number of users. The algorithm does not require interference CSI at the base station or uplink users. It is also shown that for a simple class of heterogeneous networks without sufficient channel diversity, it is not possible to achieve the corresponding interference-free system capacity. We discuss the potential for using device-to-device side-channels to overcome this limitation in heterogeneous networks.
description: 10 pages, 2 figures, to appear at IEEE International Symposium on Information Theory (ISIT) '15
(4039) Theresa Kean
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
NEW-SPECIES OF MARINE-FAUNA FROM ROSCOFF - CRUSTACEA, AMPHIPODA, SIPHONOECETES-STRIATUS-MYERS-AND-MCGRATH, AND ANNELIDA, POLYCHAETA, PARAONIDAE, PLUS NEW-DATA ON ECHINOCARDIUM-PENNATIFIDUM-NORMAN (SPATANGOIDA) DISTRIBUTION
Creators: name: Dauvin, J. C.
name: Cabioch, L.
Publisher: name: Station Biologique de Roscoff (SBR)
Year: 1988

Abstract