cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Oral misoprostol tablets (25 µg) for induction of labor: a targeted literature review and cost analysis
Creators: name: Poinas, Anne-Claire
name: Padgett, Katherine
name: de Heus, Roel
name: Perrotin, Franck
name: Devlieger, Roland
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy
subject: Infectious Diseases
subject: FOS: Health sciences

description: Various methods exist for the induction of labor (IOL), and there is limited consensus as to optimal methods. Off-label misoprostol is recommended by the World Health Organization (WHO) for IOL but preparing it into doses suitable for IOL lacks precision, with potential adverse outcomes if dosing is inaccurate. This study explores potential outcomes and costs associated with increased uptake of a low-dose (25 µg) oral misoprostol formulation (Angusta; Norgine BV, Amsterdam) approved for IOL, in France, Belgium, and the Netherlands. A literature review was undertaken to derive probabilities of delivery outcomes (vaginal, instrumental, and cesarean sections) for IOL methods, from published meta-analyses. Outcomes for oral misoprostol tablets (25 µg) were unavailable in the meta-analyses, so were estimated using data from two published retrospective cohort studies. A model was developed to predict the frequency of IOL outcomes and associated costs at the national level, across multiple scenarios. Scenarios were tested using a moderate, medium, and high increase in oral misoprostol tablet (25 µg) uptake. Market shares, costs, and induction rates were defined for each country using multiple data sources. Increased uptake of oral misoprostol tablets (25 µg) was estimated to be associated with a slightly increased rate of routine vaginal deliveries, and concurrent decreases in instrumental vaginal deliveries and cesarean sections. Since routine vaginal deliveries are less costly than other delivery outcomes, increased uptake of oral misoprostol tablets (25 µg) within the IOL market has the potential to be cost-saving. These trends were predicted using 25 µg oral misoprostol tablet outcomes informed by both retrospective studies. Preliminary outcomes suggest that oral misoprostol tablets at 25 µg per dose may improve outcomes in IOL and be cost-saving. Further study is required to validate these findings and assess the comparative efficacy of IOL methods, including oral misoprostol tablets (25 µg).
Using Backward Design to Create Research Data Management Professional Development for Information Professionals
Creators: name: Goben, Abigail
name: Nelson, Megan Sapp
Publisher: name: Zenodo
Year: 2017

description: This poster details the design process that was used to develop the Association of College and Research Libraries "Building Your Research Data Management Toolkit: Integrating RDM into Your Liaison Work" road show.nbsp; Starting with the development of learning objectives, and highlighting the multiple assessments that are offered prior to the road show experience, during the road show itself, and follows up the road show at the one month and six month post- show mark. The poster then shows the links between the learning objectives, assessments, and learning activities developed to assist learners to meet the learning objectives.
PDS: Deduce Elder Privacy from Smart Homes
Creators: name: Lee, Ming-Chang
name: Lin, Jia-Chun
name: Owe, Olaf
Publisher: name: arXiv
Year: 2020
Subjects: subject: Cryptography and Security (cs.CR)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: With the development of IoT technologies in the past few years, a wide range of smart devices are deployed in a variety of environments aiming to improve the quality of human life in a cost efficient way. Due to the increasingly serious aging problem around the world, smart homes for elder healthcare have become an important IoT-based application, which not only enables elders' health to be properly monitored and taken care of, but also allows them to live more comfortably and independently in their houses. However, elders' privacy might be disclosed from smart homes due to non-fully protected network communication. To show that elders' privacy could be substantially exposed, in this paper we develop a Privacy Deduction Scheme (PDS for short) by eavesdropping sensor traffic from a smart home to identify elders' movement activities and speculating sensor locations in the smart home based on a series of deductions from the viewpoint of an attacker. The experimental results based on sensor datasets from real smart homes demonstrate the effectiveness of PDS in deducing and disclosing elders' privacy, which might be maliciously exploited by attackers to endanger elders and their properties.
description: 31 pages, 23 figures, and 2 tables, journal paper. arXiv admin note: text overlap with arXiv:1808.07379
Additional file 4 of Characterising a human endogenous retrovirus(HERV)-derived tumour-associated antigen: enriched RNA-Seq analysis of HERV-K(HML-2) in mantle cell lymphoma cell lines
Creators: name: Tatkiewicz, Witold
name: Dickie, James
name: Franchesca Bedford
name: Jones, Alexander
name: Atkin, Mark
name: Kiernan, Michele
name: Maze, Emmanuel
name: Agit, Bora
name: Farnham, Garry
name: Kanapin, Alexander
name: Belshaw, Robert
Publisher: name: figshare
Year: 2020
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Evolutionary Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Additional file 4: Figure illustrating problem in mapping reads to proviruses that have similar sequences.
Scalable microwave-to-optical transducers at single photon level with spins
Creators: name: Xie, Tian
name: Fukumori, Rikuto
name: Li, Jiahui
name: Faraon, Andrei
Publisher: name: arXiv
Year: 2024
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Microwave-to-optical transduction of single photons will play an essential role in interconnecting future superconducting quantum devices, with applications in distributed quantum computing and secure communications. Various transducers that couple microwave and optical modes via an optical drive have been developed, utilizing nonlinear phenomena such as the Pockels effect and a combination of electromechanical, piezoelectric, and optomechanical couplings. However, the limited strength of these nonlinearities, set by bulk material properties, requires the use of high quality factor resonators, often in conjunction with sophisticated nano-fabrication of suspended structures. Thus, an efficient and scalable transduction technology is still an outstanding goal. Rare-earth ion (REI) doped crystals provide high-quality atomic resonances that result in effective second-order nonlinearities stronger by many orders of magnitude compared to conventional materials. Here, we use ytterbium-171 ions doped in a YVO$_4$ crystal at 340 ppm with an effective resonant $χ^{(2)}$ nonlinearity of ~ 10$^7$ pm/V to implement an on-chip microwave-to-optical transducer. Without an engineered optical cavity, we achieve percent-level efficiencies with an added noise as low as 1.24(9) photons. To showcase scalability, we demonstrate the interference of photons originating from two simultaneously operated transducers, enabled by the inherent absolute frequencies of the atomic transitions. These results establish REI-based transducers as a highly competitive transduction platform, provide existing REI-based quantum technologies a native link to various leading quantum microwave platforms, and pave the way toward remote transducer-assisted entanglement of superconducting quantum machines.
description: TX and RF contributed equally to this work
Efficient Algorithms for Citation Network Analysis
Creators: name: Batagelj, Vladimir
Publisher: name: arXiv
Year: 2003
Subjects: subject: Digital Libraries (cs.DL)
subject: Discrete Mathematics (cs.DM)
subject: Data Structures and Algorithms (cs.DS)
subject: FOS: Computer and information sciences
subject: E.1; G.2.2; H.3.7

description: In the paper very efficient, linear in number of arcs, algorithms for determining Hummon and Doreian's arc weights SPLC and SPNP in citation network are proposed, and some theoretical properties of these weights are presented. The nonacyclicity problem in citation networks is discussed. An approach to identify on the basis of arc weights an important small subnetwork is proposed and illustrated on the citation networks of SOM (self organizing maps) literature and US patents.
Lattice study on kaon pion scattering length in the $I=3/2$ channel
Creators: name: Miao, Chuan
name: Du, Xining
name: Meng, Guangwei
name: Liu, Chuan
Publisher: name: arXiv
Year: 2004
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: Using the tadpole improved Wilson quark action on small, coarse and anisotropic lattices, $Kπ$ scattering length in the $I=3/2$ channel is calculated within quenched approximation. The results are extrapolated towards the chiral and physical kaon mass region. Finite volume and finite lattice spacing errors are also analyzed and a result in the infinite volume and continuum limit is obtained. Our result is compared with the results obtained using Roy equations, Chiral Perturbation Theory, dispersion relations and the experimental data.
description: Latex file typeset with elsart.cls, 9 pages, 3 figures
Let it Burn : Reframing Architecture And Wldfire
Creators: name: Sokoloff, Annie
Publisher: name: The University of British Columbia
Year: 2023

description: Fire is a multifaceted phenomenon that serves as a critical tool for human advancement, yet concurrently, remains one of the most destructive forces. Fire has remained an intrinsic part of the earth and its surroundings for many millennia. However, human intervention and climate change have resulted in increasingly frequent, larger, and longer-lasting wildfires. This thesis advocates for a new approach to rural single-family housing that co-exists with wildfires, rather than working against them. Current architectural responses to rural wildfires are inadequate, and this project aims to address the increasing risk and severity of wildfires by exploring opportunities for buildings to "burn better" with non-toxic materials and a dialogue between temporary and permanent materials. The project also promotes a fundamental shift in our understanding of the value of objects and our attitudes towards material loss. This project draws inspiration from wildfire ecology, which highlights how plants have adapted to cope with the inevitability of wildfires.
Meri mathani Simon 1880
Creators: name: Rheims, Cristina A.
name: Jäger, Peter
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Sparassidae
Meri
Meri mathani

description: Meri mathani Simon, 1880
Figs 208–210, 318
Sadala mathani Simon, 1880: 327 (female lectotype and female paralectotype, here designated, from Pebas [‑3.3167, ‑718167), Loreto, Peru, no date, no collector, deposited in MNHN 2028).
Olios mathani: Simon 1897: 36; Mello-Leitão 1918: 51, fig. 28; Jäger 2020: 81 (misplaced in Olios).
Additional material examined. ECUADOR: Orellana: 1♀, Reserva Etnica Waorani, 1 km S Onkone Gare Camp (-0.9500, -76.2167), 19 January 1994, T. L. Erwin et al. leg. (USNM); 1♀, same locality as previous specimen, 25 June 1994, T. L. Erwin et al. leg. (USNM).
Diagnosis. Females of M. mathani comb. nov. are distinguished from all congeners by the MS funnel-shaped, slightly wider than long with EP along the entire length of MS (Fig. 208). Males unknown.
Redescription. Female (MNHN 2028, lectotype): Total length 13.2. Prosoma 5.0 long, 5.2 wide. Opisthosoma 7.2 long, 4.4 wide. Eyes: diameters: 0.36, 0.34, 0.20, 0.32; interdistances: 0.36, 0.15, 0.62, 0.62, 0.36, 0.26. Legs: I: 23.4 (6.6, 2.7, 6.1, 6.2, 1.8); II: 25.1 (7.2, 2.8, 6.8, 6.5, 1.8); III: 18.3 (5.7, 2.2, 4.5, 4.4, 1.5); IV: 20.3 (6.1, 2.3, 4.9, 5.3, 1.7). Epigyne: EF longer than wide; MAB inconspicuous; MS slightly longer than wide; EP triangular, slightly more than 2 times longer than wide; LL touching posteriorly (Fig. 208). Vulva: GP more than 3 times longer than wide, curving antero mediad, arising from ducts at first turn; SP ovoid; FD laterad (Figs 209–210).
Male: unknown.
Variation. Females (n = 2): total length 13.2–14.1; prosoma length 5.0–5.5; femur I length 6.5–6.6.
Distribution. Only known from the type locality (Fig. 318).
description: Published as part of Rheims, Cristina A. & Jäger, Peter, 2022, Revalidation of the genus Sadala Simon, 1880 with the description of a new genus of Neotropical huntsman spiders (Araneae, Sparassidae), pp. 1-80 in Zootaxa 5135 (1) on page 54, DOI: 10.11646/zootaxa.5135.1.1, http://zenodo.org/record/6550195
Store It in a Cool Dry Place - Processing and Long-term Preservation of Research Data
Creators: name: Alaterä, Tuomas J.
Publisher: name: Zenodo
Year: 2017

description: One crucial component of making research data accessible and reusable is preserving it properly. We know that the recipe is heavy on metadata.nbsp;But there are other ingredients too, and even the ripest data need to be carefully prepared for preservation. Furthermore, without the right tools and a cool, dry place for storage, the mission is in jeopardy from the beginning.This poster highlights the recent progress of the Finnish Social Science Data Archive. We run an institutional data repository, but have in a systematic way been preparing our collection for sustainable long-term preservation by taking advantage of an emerging national long-term preservation solution.There are four major, partly parallel, areas for development:1) Choosing sustainable file formats, migrating existing content, and updating data processing policies and software accordingly.2) Producing software for harvesting rich metadata and wrapping it with the data and contextual files into a METS container for transfer.3) Influencing to the adoption of national standards and services.4) Training the staff and administrative tasksBetter data management, increased trustworthiness and automated processes should allow us to allocate more human resources to other critical software development and data services. Our effort focuses on traditional social science data; data matrices, code and textual materials. However, the principles accepted can be adopted by other disciplines as well, given that the formats are the same. The work has been carried out in collaboration with the National Digital Library Initiative.
Additional file 5 of Characterising a human endogenous retrovirus(HERV)-derived tumour-associated antigen: enriched RNA-Seq analysis of HERV-K(HML-2) in mantle cell lymphoma cell lines
Creators: name: Tatkiewicz, Witold
name: Dickie, James
name: Franchesca Bedford
name: Jones, Alexander
name: Atkin, Mark
name: Kiernan, Michele
name: Maze, Emmanuel
name: Agit, Bora
name: Farnham, Garry
name: Kanapin, Alexander
name: Belshaw, Robert
Publisher: name: figshare
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 5: Phylogenetic tree of all HML-2 proviruses that have complete env sequences and that integrated since the human-chimpanzee divergence (~â€‰5 million years ago).
Evidence of a substellar companion to AB Dor C
Creators: name: Climent, J. B.
name: Berger, J. P.
name: Guirado, J. C.
name: Marcaide, J. M.
name: Martí-Vidal, I.
name: Mérand, A.
name: Tognelli, E.
name: Wittkowski, M.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Studies of fundamental parameters of very low-mass objects are indispensable to provide tests of stellar evolution models that are used to derive theoretical masses of brown dwarfs and planets. However, only objects with dynamically determined masses and precise photometry can effectively evaluate the predictions of stellar models. AB Dor C (0.090 solar masses) has become a prime benchmark for calibration of theoretical evolutionary models of low-mass young stars. One of the ambiguities remaining in AB Dor C is the possible binary nature of this star. We observed AB Dor C with the VLTI/AMBER instrument in low-resolution mode at the J, H and K bands. The interferometric observables at the K-band are compatible with a binary brown dwarf system with tentative components AB Dor Ca/Cb with a K-band flux ratio of 5$\pm$1% and a separation of 38$\pm$1 mas. This implies theoretical masses of 0.072$\pm$0.013 M$_{\rm \odot}$ and 0.013$\pm$0.001 M$_{\rm \odot}$ for each component, near the hydrogen-burning limit for AB Dor Ca, and near the deuterium-burning limit, straddling the boundary between brown dwarfs and giant planets, for AB Dor Cb. The possible binarity of AB Dor C alleviates the disagreement between observed magnitudes and theoretical mass-luminosity relationships.
description: 8 pages, 5 figures, accepted for publication in ApJ Letters
Modeling extracellular field potentials and the frequency-filtering properties of extracellular space
Creators: name: Bédard, Claude
name: Kröger, Helmut
name: Destexhe, Alain
Publisher: name: arXiv
Year: 2003
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Quantitative Biology (q-bio)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Extracellular local field potentials (LFP) are usually modeled as arising from a set of current sources embedded in a homogeneous extracellular medium. Although this formalism can successfully model several properties of LFPs, it does not account for their frequency-dependent attenuation with distance, a property essential to correctly model extracellular spikes. Here we derive expressions for the extracellular potential that include this frequency-dependent attenuation. We first show that, if the extracellular conductivity is non-homogeneous, there is induction of non-homogeneous charge densities which may result in a low-pass filter. We next derive a simplified model consisting of a punctual (or spherical) current source with spherically-symmetric conductivity/permittivity gradients around the source. We analyze the effect of different radial profiles of conductivity and permittivity on the frequency-filtering behavior of this model. We show that this simple model generally displays low-pass filtering behavior, in which fast electrical events (such as Na$^+$-mediated action potentials) attenuate very steeply with distance, while slower (K$^+$-mediated) events propagate over larger distances in extracellular space, in qualitative agreement with experimental observations. This simple model can be used to obtain frequency-dependent extracellular field potentials without taking into account explicitly the complex folding of extracellular space.
description: text (LaTeX), 6 figs. (ps)
Assessment of face validity of a disease model of nonsense mutation Duchenne muscular dystrophy: a multi-national Delphi panel study
Creators: name: Landfeldt, Erik
name: Zhang, Rongrong
name: Childs, Anne-Marie
name: Johannsen, Jessika
name: O'Rourke, Declan
name: Sejersen, Thomas
name: Strautmanis, Jurgis
name: Schara-Schmidt, Ulrike
name: Tulinius, Mar
name: Walter, Maggie C
name: Willis, Tracey
name: Buesch, Katharina
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: The objective of this study was to assess the face validity of a disease model evaluating the cost-effectiveness of ataluren for the treatment of nonsense mutation Duchenne muscular dystrophy (nmDMD). This was a Delphi panel study comprising of physicians with first-hand experience of ataluren for the treatment of nmDMD. Consensus was sought for previously unvalidated model data, including patient health status and quality of life measured using the Health Utility Index (HUI), mortality, informal caregiving, and the expected benefit of early ataluren treatment across four states: (1) ambulatory, (2) non-ambulatory, not yet requiring ventilation support, (3) non-ambulatory, night-time ventilation support, and (4) non-ambulatory, full-time ventilation support. Nine experts from five countries participated in the Delphi panel. Consensus was obtained for all questions after three panel rounds (except for two HUI-questions concerning hand function [dexterity]). Consensus HUI-derived utilities for state (1) were 1.0000 for ataluren on top of best supportive care (BSC) and 0.7337 for BSC alone. Corresponding estimates for state (2) were 0.3179 and 0.2672, for state (3) 0.1643 and 0.0913, and for state (4) -0.0732 and -0.1163. Consensus mortality rates for states (1), (2), and (3) were 4%, 13%, and 33%, and life expectancy in state (4) was agreed to be 3 years. Panelists further agreed that two informal caregivers typically provide day-to-day care/support to patients with nmDMD, and that starting treatment with ataluren at 2 versus 5 years of age would be expected to delay loss of ambulation by an additional 2 years, and initiation of night-time and full-time ventilation support by an additional 3 years, respectively. The main limitation concerns the size of the Delphi panel, govern primarily by the rarity of the disease. This study confirms the face validity of key clinical parameters and assumptions underlying the ataluren cost-effectiveness model.
Interpretation of wave function by coherent ensembles of trajectories
Creators: name: Kisil, Vladimir V.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences
subject: 81P05

description: We re-use some original ideas of de~Broglie, Schrödiger, Dirac and Feynman to revise the ensemble interpretation of wave function in quantum mechanics. To this end we introduce coherence (auto-concordance) of ensembles of quantum trajectories in the space-time. The coherence condition accounts phases proportional to classical action, which are in foundation of the Feynman path integral technique. Therefore, our interpretation is entirely based on well-known and tested concepts and methods of wave mechanics. Similarly to other ensemble interpretations our approach allows us to avoid all problems and paradoxes related to wave function collapse during a measurement process. Another consequence is that no quantum computation or quantum cryptography method will ever work if it assumes that a particular q-bit represents the entire wave function.
description: RevTeX, 5 pages (each English and Russian versions); v2: minor corrections; v3: post-publication additional references [33]-[36]
Optimizing the delivery of genetic and advanced diagnostic testing in the province of Ontario: challenges and implications for laboratory technology assessment and management in decentralized healthcare systems
Creators: name: Husereau, Don
name: Sullivan, Terrence
name: Feilotter, Harriet E.
name: Gomes, Marcio M.
name: Juergens, Rosalyn
name: Sheffield, Brandon S.
name: Kassam, Shaqil
name: Stockley, Tracy L.
name: Jacobs, Philip
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Medicine
Biological Sciences not elsewhere classified
Science Policy

description: The Canadian province of Ontario provides full coverage for its residents (pop.14.8 M) for hospital-based diagnostic testing. Historical governance of the healthcare system and a legacy scheme of health technology assessment (HTA) and financing has led to a suboptimal approach of adopting advanced diagnostic technology (i.e. protein expression, cytogenetic, and molecular/genetic) for guiding therapeutic decisions. The aim of this research is to explore systemic barriers and provide guidance to improve patient and care provider experiences by reducing delays and inequity of access to testing, while benefitting laboratory innovators and maximizing system efficiency. A mixed-methods approach including literature review, semi-structured interviews, and a multi-stakeholder forum involving patient representatives (n = 1), laboratory leaders (n = 6), physicians (n = 5), Ministry personnel (n = 4), administrators (n = 3), extra-provincial experts, and researchers (n = 7), as well as pharmaceutical (n = 5) and diagnostic companies (n = 2). The forum considered evidence of good practices in adoption, implementation, and financing laboratory services and identified barriers as well as feasible options for improving advanced diagnostic testing in Ontario. Overarching challenges identified included: barriers to define what is needed; need for a clear approach to adoption; and the need for more oversight and coordination. Recommendations to address these included a shift to an anticipatory system of test adoption, creating a fit-for-purpose system of health technology management that consolidates existing evaluation processes, and modernizing the governance and financing of testing so that it is managed at a care-delivery level. The proposals for change in Ontario highlight the role that HTA, governance, and financing of health technology play along the continuum of a health technology life cycle within a healthcare system where decision-making is highly decentralized. Resource availability and capacity were not a concern – instead, solutions require higher levels of coordination and system integration along with innovative approaches to HTA.
EQUILIBRIA AND WELFARE IN MARKETS WITH SOCIAL PREFERENCES
Creators: name: Fitzsimmons, Jill Ann
name: Lavoie, Nathalie
name: Lass, Daniel A.
name: Fitzsimmons, Jill Ann
name: Lavoie, Nathalie
name: Lass, Daniel A.
Publisher: name: Unknown
Year: 2019
Subjects: Institutional and Behavioral Economics

description: Presentation ID 16277
Cost-effectiveness of axicabtagene ciloleucel versus lisocabtagene maraleucel for adult patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy in the US
Creators: name: Oluwole, Olalekan O.
name: Liu, Rongzhe
name: Diakite, Ibrahim
name: Feng, Chaoling
name: Patel, Anik
name: Nourhussein, Iman
name: Snider, Julia Thornton
name: Locke, Frederick L.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Medicine
Pharmacology
Biological Sciences not elsewhere classified
Cancer
Science Policy
Hematology

description: This study evaluated from a US payer perspective the cost-effectiveness of two chimeric antigen receptor T (CAR T) cell therapies, axicabtagene ciloleucel (axi-cel) versus lisocabtagene maraleucel (liso-cel), for the treatment of adult patients with relapsed or refractory (r/r) large B-cell lymphoma (LBCL) following two or more systemic therapy lines. We developed a 3-state (i.e., pre-progression, post-progression, death) partitioned survival model to estimate patients’ lifetime outcomes. Mixture cure models were used for survival extrapolation to account for long-term remission. Survival inputs were based on a matching-adjusted indirect comparison (MAIC) that reweighted the ZUMA-1 population (receiving axi-cel) to match patient characteristics in TRANSCEND-NHL-001 (assessing liso-cel). Costs included apheresis, drug acquisition, and administration for conditioning chemotherapy and CAR T therapies, monitoring, transplant, hospitalization, adverse events, routine care, and terminal care, per published literature and databases. Utilities were derived from ZUMA-1 and literature. Deterministic and probabilistic sensitivity analyses were conducted. In the base case, axi-cel was associated with more QALYs (7.76 vs. 5.94) and greater costs overall ($611,440 vs. $597,174) than liso-cel, at $7,843/QALY gained. The incremental costs (+$14,266) were largely driven by higher routine care costs (+$18,596) due to longer survival and hospitalization (+$10,993) but partially offset by reduced costs of CAR T acquisition (‒$11,300) and terminal care (‒$4,025). Sensitivity analyses consistently suggested robustness of base-case results. This study relied on an MAIC in which trial design differences and unobserved confounders could not be accounted for. Future real-world studies for recently approved CAR T are warranted to validate our results. Due to a lack of data, we assumed equivalent use of transplants and treatment for B-cell aplasia between the two therapies based on clinicians’ opinions. In the US, axi-cel is a potentially cost-effective treatment option compared with liso-cel for adult patients with r/r LBCL after two or more systemic therapy lines.
Charge asymmetries in $γγ\to μ^+μ^- + ν_μ \barν_μ$ / $γγ\to W^\pmμ^\mp +ν_μ$ with polarized photons
Creators: name: Anipko, D. A.
name: Cannoni, M.
name: Ginzburg, I. F.
name: Panella, O.
name: Pak, A. V.
Publisher: name: arXiv
Year: 2003
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: It is shown that the difference in the distributions of positive ($μ^+$) and negative charged leptons ($μ^-$) in reactions $γγ\to μ^+μ^-+ν\barν$ and $γγ\to W^\pmμ^\mp +ν(\barν)$ at $\sqrt{s}>200$ GeV leads to observable {\em charge asymmetry} of muons which is sensitive to New Physics effects.
description: Talk presented by I. F. Ginzburg at Photon 2003: International Conference on the Structure and Interactions of the Photon and 15th International Workshop on Photon-Photon Collisions, Frascati, Italy, 7-11 Apr 2003
Wine tasting: consumer preferences for wine, choice, and sensory information
Creators: name: Weerasekara, Nadeeka D K
name: Streletskaya, Nadia A.
name: Li, Jie
name: Weerasekara, Nadeeka D K
name: Streletskaya, Nadia A.
name: Li, Jie
Publisher: name: Unknown
Year: 2019
Subjects: Institutional and Behavioral Economics

description: Presentation ID 16659
Study of Gasdynamic Electron Cyclotron Resonance Plasma Vacuum Ultraviolet Emission to Optimize Negative Hydrogen Ion Production Efficiency
Creators: name: Lapin, R. L.
name: Skalyga, V. A.
name: Izotov, I.
name: Razin, S. V.
name: Shaposhnikov, R. A.
name: Vybin, S. S.
name: Bokhanov, A. F.
name: Kazakov, M. Yu.
name: Tarvainen, O.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: Negative hydrogen ion sources are used as injectors into accelerators and drive the neutral beam heating in ITER. Certain processes in low-temperature hydrogen plasmas are accompanied by the emission of vacuum ultraviolet (VUV) emission. Studying the VUV radiation therefore provides volumetric rates of plasma-chemical processes and plasma parameters. In the past we have used gasdynamic ECR discharge for volumetric negative ion production and investigated the dependencies between the extracted H$^-$ current density and various ion source parameters. It was shown that it is possible to reach up to 80 mA/cm$^2$ of negative ion current density with a two electrode extraction. We report experimental studies on negative hydrogen ion production in a high-density gasdynamic ECR discharge plasma consisting of two simple mirror traps together with the results of VUV emission measurements. The VUV-power was measured in three ranges -- Ly$_α$, Lyman band and molecular continuum -- varying the source control parameters near their optima for H$^-$ production. It was shown that the molecular continuum emission VUV power is the highest in the first chamber while Ly$_α$ emission prevails in the second one. Modifications for the experimental scheme for further optimization of negative hydrogen ion production are suggested.
Constructing Elliptic Curves over $\mathbb{Q}(T)$ with Moderate Rank
Creators: name: Arms, Scott
name: Miller, Steven J.
name: Lozano-Robledo, Alvaro
Publisher: name: arXiv
Year: 2004
Subjects: subject: Number Theory (math.NT)
subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics
subject: 11G05 (primary), 11G20 (secondary)

description: We give several new constructions for moderate rank elliptic curves over $\mathbb{Q}(T)$. In particular we construct infinitely many rational elliptic surfaces (not in Weierstrass form) of rank 6 over $\mathbb{Q}$ using polynomials of degree two in $T$. While our method generates linearly independent points, we are able to show the rank is exactly 6 \emph{without} having to verify the points are independent. The method generalizes; however, the higher rank surfaces are not rational, and we need to check that the constructed points are linearly independent.
description: 11 pages
Meri munduruku Rheims & Jäger 2022, spec. nov.
Creators: name: Rheims, Cristina A.
name: Jäger, Peter
Publisher: name: Zenodo
Year: 2022
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Araneae
Sparassidae
Meri
Meri munduruku

description: Meri munduruku spec. nov.
Figs 211–213, 217–218, 319
Type material. Holotype: BRAZIL: Pará: ♀, Juruti, Acampamento Mutum (‑1.6124, ‑56.1942), 18 August 2011, E.G.S. Cafofo-Silva leg. (MPEG 30776).
Etymology. The specific name refers to the native indigenous group that inhabit the type locality in Juruti, southwestern Pará; noun in apposition.
Diagnosis. Females of M. munduruku spec. nov. resemble those M. arraijan spec. nov. (Figs 121–123) by the irregular hexagon shape of the MS, wider than long and widest anteriorly, in the epigyne. They are distinguished from the latter species by the pair of anterior grooves in the epigynal field (Fig. 211) and by the internal ducts with FW dilated (Fig. 212) (anterior groove single and FW slender in M. arraijan spec. nov.). Males are unknown.
Description. Female (holotype): Total length 15.7. Prosoma 6.8 long, 6.3 wide. Opisthosoma 8.5 long, 4.7 wide. Eyes: diameters 0.48, 0.42, 0.30, 0.38; interdistances: 0.40, 0.20, 0.65, 0.68, 0.35, 0.26. Legs: I: absent; II: - (8.6, 3.4, 7.8, rest of leg absent); III: 22.4 (6.9, 3.0, 5.5, 5.2, 1.8); IV: 24.3 (7.5, 2.6, 6.0, 6.3, 1.9). Spination (legs III–IV) follows the generic pattern except femur IV: r1-1-1. Epigyne: EF slightly longer than wide; MAB short and narrow; EP triangular, as wide as long, opening at posterior margin of MS; LL touching posteriorly (Figs 211, 217). Vulva: internal ducts with FW mediad; GP longer than wide, anteriad, asrising from ducts at first turn; SP ovoid; FD antero laterad (Figs 212–213, 218).
Male: unknown.
Distribution. (Fig. 319).
description: Published as part of Rheims, Cristina A. & Jäger, Peter, 2022, Revalidation of the genus Sadala Simon, 1880 with the description of a new genus of Neotropical huntsman spiders (Araneae, Sparassidae), pp. 1-80 in Zootaxa 5135 (1) on page 54, DOI: 10.11646/zootaxa.5135.1.1, http://zenodo.org/record/6550195
Spatial Economic Analysis of Parental Immunization Hesitancy in Rural Montana
Creators: name: Frimpong, Stephen
name: Xu, Chen
name: Ehmke, Mariah D.
name: Frimpong, Stephen
name: Xu, Chen
name: Ehmke, Mariah D.
Publisher: name: Unknown
Year: 2019
Subjects: Institutional and Behavioral Economics

description: Presentation ID 16728
Metadata in the Middle
Creators: name: Fallaw, Colleen
Publisher: name: Zenodo
Year: 2017

description: To participate in centralized data search and access, Illinois Data Bank (the research data repository for the University of Illinois at Urbana-Champaign) contributes and maintains records for datasets in the DataCite Metadata Store, using the EZID API through Purdue University. The organizational and technical hand-offs through the various layers can be complex to navigate.nbsp;nbsp;nbsp;On the way from research data producers to consumers, Illinois Data Bank metadata is formatted, stored, subsetted, reformatted, and passed through several organizations.nbsp;University Library = EZID at Purdue = DataCite = International DOI Foundationnbsp;If a researcher needs to correct metadata or adjust publication delay, or a curator needs to suppress a dataset while reviewing concerns, Illinois Data Bank propagates adjustments along the chain. Supporting researcher self-deposit, along with a slate of curator controls, exploits the breadth of the API and requires an understanding of the connections among components. The goal of this poster will be to present these intricacies, along with some of our technical strategies for using the EZID API, in way that implements features of the Illinois Data Bank.
Additional file 2 of Characterising a human endogenous retrovirus(HERV)-derived tumour-associated antigen: enriched RNA-Seq analysis of HERV-K(HML-2) in mantle cell lymphoma cell lines
Creators: name: Tatkiewicz, Witold
name: Dickie, James
name: Franchesca Bedford
name: Jones, Alexander
name: Atkin, Mark
name: Kiernan, Michele
name: Maze, Emmanuel
name: Agit, Bora
name: Farnham, Garry
name: Kanapin, Alexander
name: Belshaw, Robert
Publisher: name: figshare
Year: 2020
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Hematology

description: Additional file 2: Comparison of our results to those from whole transcriptome datasets in the Short Read Archive (SRA).
Graphene and its derivatives for Analytical Lab on Chip platforms
Creators: name: Sengupta, Joydip
name: Hussain, Chaudhery Mustansar
Publisher: name: arXiv
Year: 2019
Subjects: subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: Since last decade, graphene has materialized itself as one of the phenomenal materials to modern researchers because of its remarkable thermal, optical, electronic, and mechanical properties. Graphene holds enormous potentials for lab on chip (LOC) devices and can provide diverse fabrication routes and structural features due to their special electronic and electrochemical properties. A LOC device can manipulate fluids using microchannels and chamber structures, to accomplish fast, highly sensitive and inexpensive analysis with high yield. Hence, the graphene based LOC devices can constitute a well-controlled microenvironment for both advanced chemical/biological evaluation and low-cost point-of-care analysis etc. This review critically debates the graphene as a prime candidate for microfluidic devices and their future applicability towards various practical applications. Finally, the opportunities and challenges for the future of graphene with respect to their commercial challenges and sustainability perspectives are discussed.
description: Graphene, Lab-on-chip, Microchannels, Chamber structures, Commercial challenge, sustainable perceptions
Partial regularity of mass-minimizing Cartesian currents
Creators: name: Johnson, David L.
name: Smith, Penelope
Publisher: name: arXiv
Year: 2004
Subjects: subject: Differential Geometry (math.DG)
subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 49F20, 49F22, 49F10, 58A25, 53C42, 53C65

description: Let B be a fiber bundle with compact fiber F over a compact Riemannian n-manifold M. There is a natural Riemannian metric on the total space B consistent with the metric on M. With respect to that metric, the volume of a rectifiable section s:M--> B is the mass of the image s(M) as a rectifiable n-current in B. Theorem: For any homology class of sections of B, there is a mass-minimizing Cartesian current T representing that homology class which is the graph of a C^1 section on an open dense subset of M.
description: 36 pages, no figures. Published version, with minor revisions from previous arxive version
Dark energy in multi-fractional spacetimes
Creators: name: Calcagni, Gianluca
name: De Felice, Antonio
Publisher: name: arXiv
Year: 2020
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the possibility to obtain cosmological late-time acceleration from a geometry changing with the scale, in particular, in the so-called multifractional theories with $q$-derivatives and with weighted derivatives. In the theory with $q$-derivatives, the luminosity distance is the same as in general relativity and, therefore, geometry cannot act as dark energy. In the theory with weighted derivatives, geometry alone is able to sustain a late-time acceleration phase without fine tuning, while being compatible with structure-formation and big-bang nucleosynthesis bounds. This suggests to extend the theory, in a natural way, from just small-scale to also large-scale modifications of gravity. Surprisingly, the Hausdorff dimension of spacetime is constrained to be close to the topological dimension 4. After arguing that this finding might not be a numerical coincidence, we conclude that present-day acceleration could be regarded as the effect of a new restoration law for spacetime geometry.
description: 17 pages, 7 figures, 2 tables. v2: discussion improved, results unchanged, typos corrected
Additional file 3 of Characterising a human endogenous retrovirus(HERV)-derived tumour-associated antigen: enriched RNA-Seq analysis of HERV-K(HML-2) in mantle cell lymphoma cell lines
Creators: name: Tatkiewicz, Witold
name: Dickie, James
name: Franchesca Bedford
name: Jones, Alexander
name: Atkin, Mark
name: Kiernan, Michele
name: Maze, Emmanuel
name: Agit, Bora
name: Farnham, Garry
name: Kanapin, Alexander
name: Belshaw, Robert
Publisher: name: figshare
Year: 2020
Subjects: subject: Cell Biology
subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Additional file 3: Ion Torrent run summaries.
Wild ramification, the nearby cycle complexes, and the characteristic cycles of $\ell$-adic sheaves
Creators: name: Kato, Hiroki
Publisher: name: arXiv
Year: 2019
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics

description: We prove a purely local form of a result of Saito and Yatagawa. They proved that the characteristic cycle of a constructible étale sheaf is determined by wild ramification of the sheaf along the boundary of a compactification. But they had to consider ramification at all the points of the compactification. We give a pointwise result, that is, we prove that the characteristic cycle of a constructible étale sheaf around a point is determined by wild ramification at the point. The key ingredient is to prove that wild ramification of the stalk of the nearby cycle complex of a constructible étale sheaf at a point is determined by wild ramification at the point.
description: 42 pages
A Framing Effect of Sugar Content Labeling on Sugar Intake: Evidence from Online Choice Experiment
Creators: name: Kim, Sanghyo
name: Heo, Seong-Yoon
name: Kim, Sanghyo
name: Heo, Seong-Yoon
Publisher: name: Unknown
Year: 2019
Subjects: Institutional and Behavioral Economics

description: Presentation ID 15863
Solvable multi-species reaction-diffusion processes, including the extended drop-push model
Creators: name: Alimohammadi, Masoud
Publisher: name: arXiv
Year: 2004
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: By considering the master equation of asymmetric exclusion process on a one-dimensional lattice, we obtain the most general boundary condition of the multi-species exclusion processes in which the number of particles is constant in time. This boundary condition introduces the various interactions to the particles, including ones which have been studied yet and the new ones. In these new models, the particles have simultaneously diffusion, the two-particle interactions $A_αA_β\to A_γA_δ$, and the $n$-particle extended drop-push interaction. The constraints on reaction rates are obtained and in two-species case, they are solved to obtain a solvable model. The conditional probabilities of this model are calculated.
description: 14 pages. Minor changes have been done and a number of references are added. To be published in European Physical Journal B
Efficient cylindrical envelope modeling for laser wakefield acceleration
Creators: name: Massimo, Francesco
name: Zemzemi, Imen
name: Beck, Arnaud
name: Dérouillat, Julien
name: Specka, Arnd
Publisher: name: arXiv
Year: 2019
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: The resolution of the system given by Maxwell's equations and Vlasov equation in three dimensions can describe all the phenomena of interest for laser wakefield acceleration, with few exceptions (e.g. ionization). Such arduous task can be numerically completed using Particle in Cell (PIC) codes, where the plasma is sampled by an ensemble of macroparticles and the electromagnetic fields are defined on a computational grid. However, the resulting three dimensional PIC simulations require substantial resources and often yield a larger amount of information than the one necessary to study a particular aspect of a phenomenon. Reduced models, i.e. models of the Maxwell-Vlasov system taking into account approximations and symmetries, are thus of fundamental importance for preliminary studies and parametric scans. In this work, the implementation of one of these models in the code Smilei, an envelope description of the laser-plasma interaction with cylindrical symmetry, is described.
description: 9 pages, 4 figures - Submitted as a proceeding to EAAC 2019 (European Advanced Accelerator Concepts)
Neural antecedents in reflection: The application of food choice analysis with fNIRS methodology
Creators: name: Risius, Antje
name: Mehlhose, Clara
name: Ullmann, Konstanze
name: Risius, Antje
name: Mehlhose, Clara
name: Ullmann, Konstanze
Publisher: name: Unknown
Year: 2019
Subjects: Institutional and Behavioral Economics

description: Presentation ID 16551
Large distance behaviour of light cone operator product in perturbative and nonperturbative QCD regimes
Creators: name: Blok, B.
name: Frankfurt, L.
Publisher: name: arXiv
Year: 2004
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We evaluate the coordinate space dependence of the matrix elements of the commutator of the electromagnetic and gluon currents in the vicinity of the light-cone but at large distances within the parton model, DGLAP, the resummation approaches to the small x behaviour of DIS processes, and for the Unitarity Bound. We find that an increase of the commutator with relative distance $py$ as $\propto (py)f(py,y^2=t^2-r^2)$ is the generic property of QCD at small but fixed space-time interval $y^2=t^2-r^2$ in perturbative and nonperturbative QCD regimes. We explain that the factor $py$ follows within the dipole model (QCD factorization theorem) from the properties of Lorents transformation. The increase of $f(r)$ disappeares at central impact parameters if cross section of DIS may achieve the Unitarity Limit. We argue that such long range forces are hardly consistent with thermodynamic equilibrium while a Unitarity Limit may signal equilibration. Possible implications of this new long range interaction are briefly discussed.
description: 23 pages