cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Εξερευνώντας την Σαουδική Αραβία
title: Exploring Saudi Arabia
titleType: AlternativeTitle
Creators: name: Μπαντέκα, Ευαγγελή
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2022
Subjects: Σαουδική Αραβία
Ντοκουμέντο
Ταξίδι
Φωτογραφία
Saudi Arabia
Travel
Travel photography

description: Η παρούσα εργασία βασίζεται και αναφέρεται στην φωτογραφική αποτύπωση ενός ταξιδιού μου στην Σαουδική Αραβία, που πραγματοποιήθηκε τον Φεβρουάριο-Μάρτιο του 2022, μετά το άνοιγμα των συνόρων της χώρας στον τουρισμό αρχές του 2020 και την αποκλιμάκωση της πανδημίας Covid-19. Κατά την διάρκεια του ταξιδιού επιχειρήθηκε η φωτογραφική καταγραφή των φυσικών και μη αξιοθέατων της χώρας, των μνημείων πολιτισμού της, του αστικού τοπίου και της αρχιτεκτονικής των διαφόρων περιοχών της, του σημερινού τρόπου ζωής των κατοίκων της και των εναπομεινάντων αυθεντικών στοιχείων αυτής, ως ντοκουμέντο, πριν την μαζική εισβολή του τουρισμού. Η Σαουδική Αραβία που χαρακτηρίζεται ως το Λίκνο του Ισλάμ, είναι μια παραδοσιακά βαθιά συντηρητική χώρα, με πολλά ήθη, έθιμα και άγραφους νόμους, και έχει κατηγορηθεί και καταγγελθεί για πολλούς λόγους, κυρίως για την παραβίαση των ανθρωπίνων δικαιωμάτων στη χώρα, με πρώτη και ευρέως καταγγελλόμενη αυτή των δικαιωμάτων των γυναικών. Με βάση τις ιδιαιτερότητες της μέχρι πρότινος μυστηριώδους και απροσπέλαστης αυτής χώρας, με σεβασμό προς την χώρα και τους ανθρώπους της, έγινε η φωτογραφική τεκμηρίωση και εκπονήθηκε η παρούσα εργασία, σε μια προσπάθεια οπτικής προσέγγισης και σύντομης ανάλυσης των πολιτισμικών και κοινωνιολογικών στοιχείων της χώρας, με επιπλέον μια ειδική αναφορά στην σημερινή θέση της γυναίκας στην κοινωνία.
[Baumgruppe geg. Stadt]
Creators: name: Breitinger, Robert
Publisher: name: [Robert Breitinger]
Year: 1892
Subjects: Zürich

description: Zürichhorn mit Blick auf die andere Seeseite
description: [Robert Breitinger]
description: Bildtitel gemäss Zettelkatalog der Graphischen Sammlung und des Fotoarchivs
description: Gemäss dem Verzeichnis Breitingers wurde die Fotografie am 23. April 1892 um 15.40 Uhr aufgenommen. Im Verzeichnis Information zu den Wetterverhältnissen: "zi[e]mlich bede[c]kt"
description: Aus der Sammlung Breitinger (1841-1913) Exemplar der Zentralbibliothek Zürich, Graphische Sammlung und Fotoarchiv
description: Auf der Rückseite handschriftliche Notizen und oben rechts Vermerk mit roter Tinte: "1736" (Bildnummer der Kabinettkarte) Exemplar der Zentralbibliothek Zürich, Graphische Sammlung und Fotoarchiv
Emerging recombinant noroviruses identified by clinical and waste water screening
Creators: name: Lun, Jennifer H.
name: Hewitt, Joanne
name: Sitabkhan, Alefiya
name: Eden, John-Sebastian
name: Tuipulotu, Daniel Enosi
name: Netzler, Natalie Ellen
name: Morrell, Leigh
name: Merif, Juan
name: Jones, Richard
name: Huang, Bixing
name: Warrilow, David
name: Ressler, Kelly-Anne
name: Ferson, Mark J.
name: Dwyer, Dominic E.
name: Kok, Jen
name: Rawlinson, William D.
name: Deere, Daniel
name: Crosbie, Nicholas D.
name: White, Peter
Publisher: name: Institute of Environmental Science and Research
Year: 2019
Subjects: Geriatrics and gerontology
Clinical microbiology

description: Norovirus is estimated to cause 677 million annual cases of gastroenteritis worldwide, resulting in 210,000 deaths. As viral gastroenteritis is generally self-limiting, clinical samples for epidemiological studies only partially represent circulating noroviruses in the population and is biased towards severe symptomatic cases. As infected individuals from both symptomatic and asymptomatic cases shed viruses into the sewerage system at a high concentration, waste water samples are useful for the molecular epidemiological analysis of norovirus genotypes at a population level. Using Illumina MiSeq and Sanger sequencing, we surveyed circulating norovirus within Australia and New Zealand, from July 2014 to December 2016. Importantly, norovirus genomic diversity during 2016 was compared between clinical and waste water samples to identify potential pandemic variants, novel recombinant viruses and the timing of their emergence. Although the GII. 4 Sydney 2012 variant was prominent in 2014 and 2015, its prevalence significantly decreased in both clinical and waste water samples over 2016. This was concomitant with the emergence of multiple norovirus strains, including twoGII. 4 Sydney 2012 recombinant viruses, GII. P4 New Orleans 2009/GII.4 Sydney 2012 and GII. P16/GII.4 Sydney 2012, along with three other emerging strains GII. 17, GII. P12/GII.3 and GII. P16/GII.2. This is unusual, as a single GII.4 pandemic variant is generally responsible for 65-80% of all human norovirus infections at any one time and predominates until it is replaced by a new pandemic variant. In sumary, this study demonstrates the combined use of clinical and wastewater samples provides a more complete picture of norovirus circulating within the population.
Über Bürgermeister Heidegger
Creators: name: Bodmer, Johann Jakob
Publisher: name: [s.n.]
Year: 1778

description: von Professor [Johann Jakob] Bodmer
description: Siehe auch: Ms Bodmer 34.24.I
description: Notiz von der Hand eines Dr. Hirzel: Da Bodmer als 80jähriger Greis die Stadtbibliothek-Gesellschaft anno 1778 praesidirte (S. 10)
description: Gedruckt 1784 unter dem Titel ,Denkrede auf den seeligen Bürgermeister Heidegger; in dem grossen Convent auf der Bürgerbibliothek zu Zürich, den 27. Junius, gehalten von dem seel. Bodmer‘, in: Schweitzerisches Museum, Siebentes Stück. Zürich: bey Orell, Gessner, Füssli und Comp., Jg. 1 (1783/84), S. 653-663
title: Οπτική Αντίληψη: Πώς επηρεάζουν οι οπτικοαντιληπτικές δεξιότητες τη σχολική επίδοση του παιδιού
title: Visual Perception: How visual perception skills affect a child's school performance
titleType: AlternativeTitle
Creators: name: Λουμπρούκου, Αγγελική
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2022
Subjects: Όραση
Αισθητήριο
Όργανο
Σχολείο
Οπτική αντίληψη

description: Η όραση είναι ο πιο αποτελεσματικός αισθητηριακός υποδοχέας μας και μας δίνει τις περισσότερες πληροφορίες για τον κόσμο μας από κάθε άλλο αισθητήριο όργανο. Ένα παιδί τείνει να «χτίζει» τις έννοιές του για τον κόσμο και τις σχέσεις μορφής που αποτελούν αυτές τις έννοιες, έχοντας ως πυρήνα του την οπτική αντίληψη. Νευρολογικά και ψυχολογικά, η όραση καταλαμβάνει την επικρατέστερη θέση. Ο ανθρώπινος οργανισμός έχει ρυθμιστεί να χτίζει τις αντιλήψεις της μορφής, αναθέτοντας μεγαλύτερη προτεραιότητα σε οπτικά δεδομένα. Αρχικά αναλύεται η νευρολογική βάση και η ανατομία του ματιού, καθώς και οι λειτουργίες και δεξιότητες της οπτικής αντίληψης. Στη συνέχεια, αναφέρονται μοντέλα και θεωρητικές προσεγγίσεις που έχουν χρησιμοποιηθεί κατά καιρούς για την οπτική αντίληψη. Η φυσιολογική ανάπτυξη της οπτικής αντίληψης κατά την παιδική ηλικία παίζει πολύ σημαντικό ρόλο για την μετέπειτα εκπαιδευτική πορεία του παιδιού. Στόχος της παρούσας διπλωματικής είναι να αναδειχθεί ο ρόλος της οπτικής αντίληψης στο σχολείο και κατά πόσο οι οπτικοαντιληπτικές δεξιότητες του παιδιού μπορεί να επηρεάσουν την σχολική του επίδοση. Τέλος αναφέρονται κάποιες πρακτικές παρέμβασης της οπτικής αντίληψης για το σχολικό πλαίσιο. Λέξειςκλειδιά: όραση, αισθητήριο όργανο, οπτική αντίληψη, φυσιολογική ανάπτυξη, σχολικό πλαίσιο, πρακτικές παρέμβασης
Hinter diesem Haus war der Fraumünster Kreuzgang [...]
Creators: name: M. H. [H. M.]
Publisher: name: [s.n.]
Year: 1897
Subjects: Zürich

description: Abgebildet ist das ehemalige Kornhaus, das spätere Kaufhaus, das 1897 abgebrochen wurde, daneben rechts das Zunfthaus zur Meisen; hinter den an der Limmat gelegenen Gebäuden die Fraumünsterkirche und die Kirche St. Peter
description: M. H.
description: Titel gemäss rückseitiger Beschriftung, u.a. "Kaufhaus" und "Meise"
description: Der Fotograf kann nicht näher identifiziert werden
Shear localisation in the elastohydrodynamic lubrication regime
Creators: name: Jeffreys, Stephen
Publisher: name: Imperial College London
Year: 2020

description: Understanding the shear behaviour of lubricants subject to high shear stresses and high shear rates is crucial to successfully model elastohydrodynamic friction. A method for determining this is through measuring the flow condition. Three in situ luminescence-based velocimetry techniques have been applied to a point contact with submicron film thickness. The techniques focus on quantifying through-film velocity distributions to understand the validity of flow assumptions used in modelling EHL. Nanoparticle tracking velocimetry was investigated to see whether the flow behaviour could be determined from nanoparticle velocity distributions. A protocol was developed deriving formal relations between nanoparticle velocity distributions, nanoparticle concentration distributions and through-film fluid flow velocity distributions, obtained using molecular tagging velocimetry (MTV). Nanoparticle velocity distributions were found to be pressure dependent. Results were proved quantitatively that the pressure dependency was consistent with the observed change in the flow condition; as the flow changed from Couette to partial plug flow above a critical pressure. The work presents for the first time simultaneous measurements of the velocity and temperature in elastohydrodynamic lubricant films. MTV was applied to determine through-film velocity profiles of a polyphenyl ether lubricant film operating in the EHL under high pressure and high shear. In this work, velocity profiles severely deviate from Couette shear and exhibit shear localisation. The flow behaviour is heavily dependent on the thermal conductivity of the contacting surfaces and shear heating, changing the through-film position of localised shear. A novel complementary molecular tagging thermometry technique, based on the principle of phosphorescence lifetime, was developed and applied to confirm through-film temperature gradients. At higher pressures, the flow behaviour is dominated by the normal pressure, which is observed through a strong asymmetric shape resembling a glassy partial plug. The work provides an improved understanding of the parameters leading to flow heterogeneity in elastohydrodynamic lubricant films.
title: Ο ρόλος της προϊσταμένης του νηπιαγωγείου στην εισαγωγή και διαχείριση καινοτόμων δράσεων και αλλαγών στην εκπαιδευτική μονάδα
title: The role of the kindergarten principal in introducing and managing innovative activities and changes to the educational unit
titleType: AlternativeTitle
Creators: name: Τσώλης, Εμμανουήλ
name: Κρίκου, Δέσποινα
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2022
Subjects: Προσχολική εκπαίδευση
Σχολική καινοτομία
Προϊσταμένη νηπιαγωγείου
Ηγεσία
Διευθυντές σχολικών μονάδων
Διευθυντής
Ηγέτης
Καινοτομία

description: Οι προκλήσεις του 21ου αιώνα απαιτούν ένα σχολείο ανοιχτό, ευέλικτο, συνεχώς εξελισσόμενο, καινοτόμο, το οποίο προσαρμόζεται στα νέα δεδομένα που ορίζει η ψηφιακή εποχή και ψηφιακή κοινωνία. Καθοριστικό ρόλο στην υποστήριξη και προώθηση της σχολικής καινοτομίας διαδραματίζει ο διευθυντής/ προϊστάμενος/ηγέτης. Αυτός θα καθορίσει την πορεία, την ποιότητα και τον βαθμό καινοτομίας και σε συνεργασία με τους υφιστάμενους εκπαιδευτικούς θα επιχειρήσουν να εφαρμόσουν τις αλλαγές στη σχολική μονάδα. Ωστόσο, η επιτυχία του όλου εγχειρήματος θα κριθεί από την αποτελεσματικότητα, τις ηγετικές ικανότητες, τις προσωπικές δεξιότητες και τα χαρακτηριστικά της προσωπικότητας του διευθυντή/ προϊστάμενου/ηγέτη. Σκοπός της παρούσας εργασίας είναι η διερεύνηση των απόψεων τεσσάρων προϊσταμένων νηπιαγωγείων σχετικά με την εφαρμογή καινοτόμων εκπαιδευτικών ή διοικητικών προγραμμάτων στις σχολικές τους μονάδες. Μέσα από τις απόψεις τους θα επιχειρήσουμε να αναλύσουμε την υφιστάμενη κατάσταση σχετικά με τον βαθμό και την έκταση εφαρμογής καινοτόμων εκπαιδευτικών ή διοικητικών πρακτικών στα ελληνικά νηπιαγωγεία. Η έρευνα διεξήχθη στο νομό Αττικής και ακολούθησε την ποιοτική προσέγγιση συλλογής δεδομένων, μέσω των συνεντεύξεων των τεσσάρων προϊσταμένων νηπιαγωγείων.
title: Big Data in den Sozial-, Verhaltens- und Wirtschaftswissenschaften: Datenzugang und Forschungsdatenmanagement - Mit Gutachten "Web Scraping in der unabhängigen wissenschaftlichen Forschung"
Creators: name: Rat Für Sozial- Und Wirtschaftsdaten (RatSWD)
Publisher: name: German Data Forum ( RatSWD)
Year: 2019

description: RatSWD Output Paper Series
Sonnenfleckenzeichnung Nr. 3533.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 17.01.1902, erstellt von Alfred Wolfer
Creators: name: Eidgenössische Sternwarte in Zürich (ETH Zürich bzw. vor 1911 Polytechnikum)
Publisher: name: [s.n.]
Year: 1902

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Kern-Merz-Refraktor.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zugeordnete numerische Werte wurden in einer separat geführten, chronologischen Tabelle erfasst. Unter Umständen sind tabellarisch notierte Werte, die für Protuberanzen mit rot geschrieben wurden, direkt auf der Fleckenzeichnung vermerkt
description: ETH-Bibliothek
title: Μελέτη προβλημάτων ποιότητας ισχύος από παλμικά φορτία για συστήματα ηλεκτρικής ενέργειας πλοίων
title: Study of power quality disturbances from pulse loads in power electric systems on ships
titleType: AlternativeTitle
Creators: name: Κολερός, Αθανάσιος
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2022
Subjects: Παλμικά φορτία
Συστήματα ηλεκτρικής ενέργειας
Πλοία
Πρόωση πλοίων
Ποιότητα ισχύος
Αρμονικές συνιστώσες

description: Βασικός σκοπός της παρούσας εργασίας είναι η μελέτη των προβλημάτων ποιότητας ισχύος στα συστήματα ηλεκτρικής ενέργειας πλοίων μέσω θεωρητικής ανάλυσης και προσομοίωσης.
Sonnenfleckenzeichnung Nr. 3530.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 12.01.1902, erstellt von Alfred Wolfer
Creators: name: Eidgenössische Sternwarte in Zürich (ETH Zürich bzw. vor 1911 Polytechnikum)
Publisher: name: [s.n.]
Year: 1902

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Kern-Merz-Refraktor.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zugeordnete numerische Werte wurden in einer separat geführten, chronologischen Tabelle erfasst. Unter Umständen sind tabellarisch notierte Werte, die für Protuberanzen mit rot geschrieben wurden, direkt auf der Fleckenzeichnung vermerkt
description: ETH-Bibliothek
Le château Grepplang du Côté de Flums
Creators: name: Rahn, Johann Rudolf
Publisher: name: [s.n.]
Year: 1870

description: Dargestellt wird eine Aussenansicht der Burg Gräpplang bei Flums
description: [Johann Rudolf Rahn]
description: Handschriftliche Notiz von Johann Rudolf Rahn "Colorirte Federzeichnung ca Ende XVIII Jhdte i Besitz des Herrn Landammann G. Muheim in Altorf"
Burg ob Grestis bei Villers (Sargans)
Creators: name: Immler, Paul Peter
Publisher: name: [s.n.]
Year: 1862
Subjects: Archäologische Stätte

description: Dargestellt wird ein Plan der archäologischen Fundstelle auf dem Plateau Severgall bei Vilters-Wangs. An dieser Stelle konnten frühere Ansiedlungen nachgewiesen werden, eine eigentliche Burg stand allerdings nie auf dem Severgall. Immler hat um 1850 als einer der ersten dort Ausgrabungen durchgeführt
description: Aufnahme von P. Immler
description: Paul Peter Immler hat handschriftlich notiert "Sammlung Dr. A Nüscheler-Usteri". Zudem hat Immler einzelne Elemente der Darstellung beschriftet oder mit Buchstaben versehen. Diese werden in der angefügten Legende aufgelöst
Preliminary evaluation of BioFire FilmArray(A (R)) Gastrointestinal Panel for the detection of noroviruses and other enteric viruses from wastewater and shellfish
Creators: name: Gyawali, Pradip
name: Croucher, Dawn
name: Hewitt, Joanne
Publisher: name: Institute of Environmental Science and Research
Year: 2019
Subjects: Infectious diseases
Microbiology not elsewhere classified
Infectious agents
Plant cell and molecular biology
Animal cell and molecular biology

description: The BioFire FilmArray(A (R)) Gastrointestinal Panel was evaluated for the rapid detection of adenovirus, astrovirus, norovirus, rotavirus and sapovirus from influent and effluent wastewater and shellfish. The multiplex BioFire FilmArray(A (R)) Gastrointestinal Panel compared well to singleplex qPCR/RT-qPCR methods for the detection of adenovirus, astrovirus, rotavirus and sapovirus from influent and effluent wastewater samples. However, the BioFire FilmArray(A (R)) Gastrointestinal Panel showed poor performance for the detection of norovirus, significantly underestimating its presence in wastewater and shellfish samples when compared with the singleplex norovirus GI and GII RT-qPCR assays. Therefore, improvement on detection efficiency for norovirus from environmental and food samples is necessary before using results from the FilmArray(A (R)) Gastrointestinal Panel to assess associated public health risks.
"Abriss des uhralten Fürstlichen Hauses Habspurg, wie es noch diser Zeitt gesächen wirt". (Wappenbuch, gez. von Hans Ulrich Fisch, Aarau 1634. Mter. der Stadtbibliothek Luzern
Creators: name: Zemp, Josef
Publisher: name: [s.n.]
Year: 1892

description: Dargestellt wird eine Aussenansicht der Burg Habsburg. Die Zeichnung von Zemp ist eine Kopie einer früheren Darstellung von Hans Ulrich Fisch aus dem Jahr 1634. Die Zeichnung Fischs ist Teil dessen Wappenbuchs und gilt als älteste bekannte realitätsnahe Darstellung der Burg Habsburg
description: JZ [Monogramm]
description: JZ = Joseph Zemp
Interactive effects of age and respiratory virus on severe lower respiratory infection
Creators: name: Prasad, Namrata
name: Trenholme, A. A.
name: Huang, Qiu Sue
name: Thompson, M. G.
name: Pierse, N.
name: Widdowson, M. A.
name: Wood, Tim
name: Seeds, R.
name: Taylor, S.
name: Grant, C.C.
name: Newbern, Elizabeth Claire
name: team, SHIVERS
Publisher: name: Institute of Environmental Science and Research
Year: 2019
Subjects: Epidemiology not elsewhere classified
Cardiology (incl. cardiovascular diseases)

description: We investigated risk factors for severe acute lower respiratory infections (ALRI) among hospitalised children <2 years, with a focus on the interactions between virus and age. Statistical interactions between age and respiratory syncytial virus (RSV), influenza, adenovirus (ADV) and rhinovirus on the risk of ALRI outcomes were investigated. Of 1780 hospitalisations, 228 (12.8%) were admitted to the intensive care unit (ICU). The median (range) length of stay (LOS) in hospital was 3 (1-27) days. An increase of 1 month of age was associated with a decreased risk of ICU admission (rate ratio (RR) 0.94; 95% confidence intervals (CI) 0.91-0.98) and with a decrease in LOS (RR 0.96; 95% CI 0.95-0.97). Associations between RSV, influenza, ADV positivity and ICU admission and LOS were significantly modified by age. Children <5 months old were at the highest risk from RSV-associated severe outcomes, while children >8 months were at greater risk from influenza-associated ICU admissions and long hospital stay. Children with ADV had increased LOS across all ages. In the first 2 years of life, the effects of different viruses on ALRI severity varies with age. Our findings help to identify specific ages that would most benefit from virus-specific interventions such as vaccines and antivirals.
The 2014 national survey of pesticides in groundwater in New Zealand
Creators: name: Close, Murray E.
name: Humphries, Bronwyn
Publisher: name: Institute of Environmental Science and Research
Year: 2019
Subjects: Environmental assessment and monitoring
Other environmental sciences not elsewhere classified
Natural resource management

description: A total of 165 wells were sampled as part of the 2014 national survey of pesticides in groundwater, a survey that is conducted on a four-yearly basis. The survey aims were to update the national overview of pesticides in New Zealand’s groundwater systems, to investigate temporal variation in pesticide concentrations, and to identify environmental factors associated with pesticide contamination. Samples were analysed for around 80 pesticides using gas chromatography with mass spectrometry detection. Pesticides were detected in 28 wells (17%), with two or more pesticides detected in 10 wells (6%). Pesticides were detected in wells from six of the 13 regions sampled. One well contained a pesticide (dieldrin) at a concentration greater than the maximum acceptable value (MAV) for drinking water. Twenty-one different pesticides were detected, with most concentrations being less than 0.1 mg m-3. Only four of the 51 pesticide detections exceeded a con centration of 1 mg m-3. Comparisons with earlier surveys indicate similar levels of pesticide detections in groundwater over the last 12 years, with higher levels of detections before that time. The majority of wells sampled in each national survey have not had pesticides detected; where detected, the concentrations were mostly less than 0.1 mg m-3 and, with the exception of dieldrin and terbuthylazine, less than 5% of MAVs.
title: Cultured meat consumer acceptance
title: Μελέτη αποδοχής καταναλωτών του κρέατος κυτταροκαλλιέργειας
titleType: AlternativeTitle
Creators: name: Κουγιουμουτζόγλου, Σπυριδούλα
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2022
Subjects: Kρέας κυτταροκαλλιέργειας
Kαταναλωτής

description: Η αύξηση της κατανάλωσης κρέατος τείνει να κάνει τις κτηνοτροφικές μονάδες μη βιώσιμες στο μέλλον. Επίσης έχει διαπιστωθεί ότι το κρέας λόγω των αντιβιοτικών και άλλως βλαβερών ουσιών που περιέχει βλάπτει την ανθρώπινη υγεία. Γι’ αυτούς τους λόγους αλλά και για πολλούς άλλους οι επιστήμονες οδηγήθηκαν στην εύρεση μίας νέας τεχνολογίας με στόχο το κρέας να κατασκευάζεται σε εργαστήριο. Σκοπός της παρούσας μελέτης είναι να ερευνηθεί κατά πόσο οι Έλληνες καταναλωτές θα μπορούσαν να αποδεχτούν αυτή τη νέα τεχνολογία. Δηλαδή η στάση τους απέναντι στο κρέας κυτταροκαλλιέργειας και η ενδεχόμενη πληρωμή του. Ακόμα στόχος αυτής της έρευνας είναι να συγκριθεί με άλλες έρευνες που έχουν γίνει στην Ευρώπη. Η μελέτη αυτή χωρίζεται σε τρία μέρη. Αρχικά δίνονται πληροφορίες για το κρέας κυτταροκαλλιέργειας και την τεχνολογία παρασκευής τους. Το δεύτερο μέρος της εργασίας αφορά την έρευνα και τα αποτελέσματα της και το τρίτο μέρος σχολιάζονται οι κυριότερες έρευνες που αφορούν την αποδοχή του κρέατος κυτταροκαλλιέργειας από τους καταναλωτές. Τα αποτελέσματα έδειξαν πως οι καταναλωτές δεν είναι διατεθειμένοι να πληρώσουν παραπάνω για το κρέας κυτταροκαλλιέργειας από το συμβατικό κρέας. Επιπλέον, τα αποτελέσματα έδειξαν ότι οι χορτοφάγοι δέχονται αυτό το προϊόν κυρίως ως μία άλλη λύση για αυτούς που καταναλώνουν κρέας και όχι για δικής τους κατανάλωση, ενώ οι κρεατοφάγοι θεωρούν ότι το κρέας κυτταροκαλλιέργειας δεν πρέπει να αντικαταστήσει το συνηθισμένο κρέας.
Directed evolution of potassium channels for the understanding of neuronal activity including mechanisms of sleep and anaesthesia
Creators: name: Le, Lily Wong
Publisher: name: Imperial College London
Year: 2019

description: Directed evolution is a technique able to modify functions on existing proteins which won the Noble Prize for Chemistry in 2018. It is based on diversifying the DNA coding sequence of the target protein, expression in a biological platform, and applying a selection pressure for screening. This is repeated for several rounds, each time generating incremental mutations directing the protein towards carrying out the desired function. Directed evolution has led to the production of molecules which have contributed to the understanding of neuronal activity underlying a range of physiological phenomena including loss of consciousness during sleep and anaesthesia. This thesis includes a short review of optogenetic tools developed by the technique including genetically-encoded calcium indicators which fluoresce upon detecting intracellular calcium ion influx and genetically-encoded voltage indicators which fluoresce upon detecting change in membrane potential of neurons. An additional short review covers the handful of metabotropic designer receptors exclusively activated by designer drugs also developed by the same technique. In an endeavour to further contribute to this field, we have conducted preliminary studies on ionotropic channels 5HT3A, and tandem two-pore potassium channels TASK3, TREK1, and TOK1 onto which directed evolution could be applied to add to this molecular toolbox. Parallel preliminary experiments, also preparing for directed evolution, investigate the binding site of halothane anaesthetic on TOK1 in order to better understand the activation mechanism of halothane on tandem two-pore potassium channels. Further work suggests experiments on TOK1 to conduct directed evolution and future perspectives for the developed molecules: a TOK1 receptor hypersensitive to halothane and a TOK1 receptor exclusively activated by Compound 21, a designer drug with no physiological targets.
Hallwyl
Creators: name: Rahn, Johann Rudolf
Publisher: name: [s.n.]
Year: 1859
Subjects: Seengen

description: Dargestellt wird eine Aussenansicht des Wohnhauses auf der Vorderen Insel des Schlosses Hallwil in Seengen
description: JR [Monogramm]
description: JR = Johann Rudolf Rahn
Genome sequence of a podovirus (AAPEc6) isolated from wastewater in New Zealand that infects Escherichia coli O45:H10
Creators: name: Nonis, Judith
name: Premaratne, Aruni
name: Billington, Craig
name: Varsani, Arvind
Publisher: name: Institute of Environmental Science and Research
Year: 2019
Subjects: Genomics
Genetics not elsewhere classified
Infectious diseases
Microbial genetics

description: Bacteriophages are ideal candidates for pathogen biocontrol to mitigate outbreaks of prevalent foodborne pathogens, such as Escherichia coli. We identified a bacteriophage (AAPEc6) from wastewater that infects E. coli O45:H10. The AAPEc6 genome sequence shares 93% identity (with 92% coverage) to enterobacterial phage K1E (Sp6likevirus) in the Autographivirinae subfamily (Podoviridae).
Hallwyl
Creators: name: Rahn, Johann Rudolf
Publisher: name: [s.n.]
Year: 1893
Subjects: Seengen

description: Dargestellt wird in zweifacher Ausführung (Raumansicht sowie Grundriss) das Einstiegsloch zum Gefängnis, das sich im untersten Geschoss eines Turms auf der Vorderen Insel des Schlosses Hallwil in Seengen befunden hat
description: J Rahn
description: Handschriftliche Notiz von Johann Rudolf Rahn "Gefängnisthurm neben der Nordostecke des hinteren Hauses. Einsteigeloch auf der Höhe der Terrasse"
Hallwyl
Creators: name: Rahn, Johann Rudolf
Publisher: name: [s.n.]
Year: 1860
Subjects: Seengen

description: Dargestellt wird eine Rundscheibe, die eine Aussenansicht des Schlosses Hallwil in Seengen zeigt
description: [Johann Rudolf Rahn]
description: Handschriftliche Notiz von Johann Rudolf Rahn "Rundscheibe Hans Wolff von Hapsburg. 1540. I Besitz des Herrn v Hallwil i Stockholm. Die Scheibe befand sich früher auf Schloss Hallwil"
Investigating the Metabolic Role of Interleukin-10 in Inflammatory Macrophages
Creators: name: Afzal, Remsha
Publisher: name: Royal College of Surgeons in Ireland
Year: 2022
Subjects: subject: Immunology
subject: FOS: Clinical medicine
subject: Molecular Biology
subject: 60104 Cell Metabolism
subject: FOS: Biological sciences

description: Interleukin-10 (IL-10) is a pleotropic cytokine implicated in infection-associated immunopathology, autoimmunity, and allergy. It was tested as a potential therapeutic agent against several inflammatory and autoimmune disorders. However, systemic IL-10 administration proved to be of limited value, which indicated that its production needed to be carefully targeted in order to be efficacious therapeutically. Hence, research focus shifted on understanding the regulation of IL-10’s downstream targets, so they could be utilised instead in a more cell-specific approach to therapy.Macrophages are regulated by the modulation of metabolic events, and can shift their functional status in response to their changing microenvironmental stimuli. The focus of this project was to investigate how IL-10 impacted on inflammatory macrophage metabolism and whether manipulating targets of IL-10 could result in a reduced inflammatory burden overall. Here, I uncover two targets of IL-10, both part of the arginine-polyamine pathway, as being attractive candidates for modulating macrophage polarisation. The first target, Spermine oxidase (Smox), is a catabolic enzyme of the polyamine pathway, which was upregulated in lipolysaccharide (LPS)-stimulated inflammatory macrophages, but was significantly inhibited in the presence of IL-10. Chemical inhibition of Smox in LPS-treated cells significantly reduced cytotoxicity, pro-inflammatory cytokine secretion, and reactive oxygen species (ROS) production.The second target that is more extensively characterised in this thesis is the mitochondrial isoform of arginase, Arginase-2 (Arg2), which was significantly enhanced by the presence of IL-10 in LPS-stimulated murine and human macrophages. I demonstrated that Arg2 was essential for enhancing mitochondrial respiration in both quiescent and inflammatory macrophage cells. I further delineated that Arg2 enhanced macrophage mitochondrial respiration by enhancing the activity and assembly of a particular node of the electron transport chain at Complex II/Succinate dehydrogenase (Sdh). The product of Sdh, the metabolite fumarate, was found to be downregulated in Arg2–/– macrophages, while the substrate of Sdh, succinate was upregulated. This finding correlated with a significant increase in the expression of the transcription factor Hypoxia Inducible Factor-1α (HIF-1α) and the pro-inflammatory cytokine Interleukin-1β (IL-1β) in the Arg2–/– cells. Collectively, this is the first report of the Arg2 isoform affecting mitochondrial oxidative output in an immune cell type, which in turn modulates the overall inflammatory output of the cell.
Complete genome sequence of Campylobacter concisus ATCC 33237(T) and draft genome sequences for an additional eight well-characterized C. concisus strains
Creators: name: Cornelius, Angela
name: G Miller, William
name: J. Lastovica, Albert
name: On, Stephen L. W.
name: French, Nigel P.
name: Vandenberg, Olivier
name: Biggs, Patrick J.
Publisher: name: Institute of Environmental Science and Research
Year: 2019
Subjects: Genomics
Genetics not elsewhere classified
Infectious diseases
Infectious agents

description: We report the complete genome sequence of the Campylobacter concisus type strain ATCC 33237 and the draft genome sequences of eight additional well-characterized C. concisus strains. C. concisus has been shown to be a genetically heterogeneous species, and these nine genomes provide valuable information regarding the diversity within this taxon.
[Aussenansicht des Turms in Halten]
Creators: name: Rahn, Johann Rudolf
Publisher: name: [s.n.]
Year: 1892
Subjects: Halten, Solothurn

description: JR [Monogramm]
description: JR = Johann Rudolf Rahn
description: Die Zeichnung ist abgebildet in: Johann Rudolf Rahn: Die Mittelalterlichen Kunstdenkmäler des Cantons Solothurn, Zürich 1893, S. 93
The ADDRESS-2 cohort: database management & data analysis evaluating the characteristics and predictors of early remission in people with incident type 1 diabetes
Creators: name: Kaur, Akaal
Publisher: name: Imperial College London
Year: 2021

description: Type 1 diabetes (T1D) is an autoimmune disease characterised by loss of pancreatic β-cell function and is heterogeneous in its presentation and progression. Some recently diagnosed individuals may experience transient β-cell recovery (partial remission), characterised by low insulin requirements and good glycaemic control. ADDRESS-2 recruits individuals aged ≥5 years, within 6 months of a clinician-assigned diagnosis of T1D. Recruitment is facilitated by NIHR Clinical Research Network research nurses across 156 sites in the U.K. Participant’s demographic, medical and family history, clinical and biochemistry data within the first year of diagnosis are recorded on an online database. An optional blood sample is obtained for the measurement of islet autoantibodies, and storage of serum and DNA. This thesis first explores ADDRESS-2 data validation issues and the data preparation methodologies adopted to maintain data integrity, particularly in relation to insulin medication and clinical and biochemistry data structuring. Subsequent chapters then explore the research potential of ADDRESS-2 with analysis of (1) cohort characteristics in adults and children; (2) predictors of glycaemic control, measured by random and fasting plasma glucose (RPG and FPG) and HbA1c; and (3) predictors of partial remission. Adults were more likely than children to present in diabetic ketoacidosis (DKA), with weight loss and fatigue, a longer symptom duration, a higher HbA1c, and were more likely to be autoantibody negative. As measures of glycaemic control, RPG and FPG had multiple independent predictors at diagnosis, but no significant predictors subsequently. In contrast, HbA1c exhibited a broad range of predictors at and after diagnosis. Five definitions of partial remission were investigated. For all definitions, increasing age, male gender and the absence of DKA were independent predictors. Depending on the definition, 51-80% of individuals in partial remission had a c-peptide concentration > 300 pmol/l. In conclusion, after careful attention to data validation and structuring, this large, multicenter database could be highly informative regarding real-world T1D characteristics.
Haltenthurm bei Kriegstetten (Solothurn)
Creators: name: Rahn, Johann Rudolf
Publisher: name: [s.n.]
Year: 1892
Subjects: Halten, Solothurn

description: Dargestellt wird eine Aussenansicht des Wohnturms in Halten
description: [Johann Rudolf Rahn]
description: Die Zeichnung ist eine Vorstudie zur Abbildung in: Johann Rudolf Rahn: Die Mittelalterlichen Kunstdenkmäler des Cantons Solothurn, Zürich 1893, S. 93
description: Johann Rudolf Rahn hat zweimal handschriftlich notiert "Putz"
Understanding geological evolution of chalk cliffs and coastal processes using InSAR
Creators: name: Mider, Malgorzata
Publisher: name: Imperial College London
Year: 2021

description: A tenth of the world’s population lives in coastal zones (Evans, 2004), where human activity and rising global sea levels intensify the erosion and flooding. To enable the coastal area to remain viable for human use, reliable and repeatable methods of monitoring are necessary, along with better understanding of geological processes that can be encountered in such areas. Current monitoring methods are often expensive, requiring specialist equipment, which can prove problematic when trying to gain access to the coast, work can be weather and/or tide dependant. Space-borne Synthetic Aperture Radar Interferometry (InSAR) is increasingly used to monitor ground motions related to natural and anthropogenic geohazards with up to millimetre accuracy. The European Space Agency (ESA) satellites, Sentinel-1A and 1B, provide freely available detailed data with repeat time of 6 days. The aim of this research was to investigate and understand use of InSAR data for monitoring and analysis of geological processes affecting coastal zones. The focus of the research is downwearing and erosion of the shoreline, cliff collapse and rotational landslides. Permanent Scatterer Interferometry (PSI) technique was used on Sentinel-1 data to measure surface deformation and relate to these coastal processes and mechanisms. The UK chalk coast was selected for the research sites, the results show that identifying evidence of vertical cliff collapses was very challenging and the results were inconclusive, mainly due to the vegetation present, leading to a loss of coherence. Platform downwearing can be successfully monitored both at a local and regional scale, and large scale coastal, rotational landslides can also be successfully monitored. This has been performed to sub-millimetre accuracy and allowed for the natural processes to be interpreted. The effectiveness of the PSI methodology as a monitoring tool for coastal environments has been shown, especially when coupled with conventional monitoring methods.
Interactive effects of age and respiratory virus on severe lower respiratory infection
Creators: name: Prasad, Namrata
name: Trenholme, A. A.
name: Huang, Qiu Sue
name: Thompson, M. G.
name: Pierse, N.
name: Widdowson, M. A.
name: Wood, Tim
name: Seeds, R.
name: Taylor, S.
name: Grant, C.C.
name: Newbern, E. C.
name: team, SHIVERS
Publisher: name: Institute of Environmental Science and Research
Year: 2019
Subjects: Epidemiology not elsewhere classified
Cardiology (incl. cardiovascular diseases)

description: We investigated risk factors for severe acute lower respiratory infections (ALRI) among hospitalised children <2 years, with a focus on the interactions between virus and age. Statistical interactions between age and respiratory syncytial virus (RSV), influenza, adenovirus (ADV) and rhinovirus on the risk of ALRI outcomes were investigated. Of 1780 hospitalisations, 228 (12.8%) were admitted to the intensive care unit (ICU). The median (range) length of stay (LOS) in hospital was 3 (1-27) days. An increase of 1 month of age was associated with a decreased risk of ICU admission (rate ratio (RR) 0.94; 95% confidence intervals (CI) 0.91-0.98) and with a decrease in LOS (RR 0.96; 95% CI 0.95-0.97). Associations between RSV, influenza, ADV positivity and ICU admission and LOS were significantly modified by age. Children <5 months old were at the highest risk from RSV-associated severe outcomes, while children >8 months were at greater risk from influenza-associated ICU admissions and long hospital stay. Children with ADV had increased LOS across all ages. In the first 2 years of life, the effects of different viruses on ALRI severity varies with age. Our findings help to identify specific ages that would most benefit from virus-specific interventions such as vaccines and antivirals.
Hegi. Schlosskapelle
Creators: name: Rahn, Johann Rudolf
Publisher: name: [s.n.]
Year: 1861
Subjects: Schlosskapelle
Winterthur

description: Dargestellt wird eine Innenansicht gegen Osten der Kapelle im Schloss Hegi in Winterthur. Zudem hat Johann Rudolf Rahn daneben Skizzen architektonischer Details angefügt
description: [Johann Rudolf Rahn]
description: Handschriftliche Notizen von Johann Rudolf Rahn zu den einzelnen Darstellungen, v.o.n.u. "Profile a [der] Thüre", "Thüre 1/10 natürl Grösse", "Profile der Gewölbgurten" und "[...]"
Schloss Hegi
Creators: name: Rahn, Johann Rudolf
Publisher: name: [s.n.]
Year: 1861
Subjects: Wappen
Schlosskapelle
Winterthur

description: Dargestellt werden mehrere Skizzen von Säulen im Schloss Hegi in Winterthur. Rahn hat zudem zwei sich an den Säulen befindende Wappen dargestellt: Links das geviertelte Wappen mit dem Wappen des Bistums Konstanz, ein rotes Kreuz auf weissem Feld und dem Wappen der Hohen-Landenberg, drei weisse Ringe auf rotem Feld, abwechselnd mit gelben und schwarzen Würfeln. Rechts ist das Wappen der Familie Hegi dargestellt. Daneben befindet sich eine weitere Wappendarstellung
description: [Johann Rudolf Rahn]
description: Johann Rudolf Rahn hat die einzelnen Darstellungen handschriftlich beschriftet
Helfenberg
Creators: name: Immler, Paul Peter
Publisher: name: [s.n.]
Year: 1865
Subjects: Gossau, Kanton Sankt Gallen

description: Dargestellt wird der Grundriss der Burgruine Helfenberg bei Gossau
description: PI [Monogramm]
description: Paul Peter Immler hat handschriftlich notiert "Sammlung A Nüscheler-Usteri"
description: PI = Paul Peter Immler
description: Johann Rudolf Rahn hat auf dem Unterlagenblatt handschriftlich notiert "[...] Gossau"
Development of an Integrated Device-RNAi Particle Platform for the Treatment of Cystic Fibrosis via Inhalation
Creators: name: Gaul, Rachel
Publisher: name: Royal College of Surgeons in Ireland
Year: 2022
Subjects: subject: 111504 Pharmaceutical Sciences
subject: FOS: Clinical medicine
subject: 100401 Gene and Molecular Therapy
subject: FOS: Medical biotechnology
subject: Molecular Biology
subject: 110203 Respiratory Diseases
subject: 100709 Nanomedicine
subject: FOS: Nanotechnology

description: Cystic fibrosis (CF) is an inherited disorder caused by a mutation in the CFTR gene and characterised by progressive lung damage due to cycles of infection and inflammation. Gene-based therapies have been proposed as a potential treatment approach for CF. MicroRNA (miRNA) are short 21-24 nucleotide duplex RNAs responsible for post-transcriptionally regulating protein expression. We have identified a miRNA of interest, miR-146a which has previously been shown to target IRAK1 and TRAF6 signalling, thereby reducing inflammation. Herein we investigate the potential role of miR-146a in CF and its therapeutic potential. Delivery of exogenous miRNA therapeutics is a growing area of interest. However, their clinical translation is limited by the availability of safe and effective delivery systems. Novel star-polypeptide/peptoids are promising gene vectors capable of forming polyplexes with nucleic acids. In this work, we evaluate for the first time the star-polypeptides as miRNA carriers to prepare innovative miRNA-nanomedicines for treatment of CF via nebulisation.The levels of IRAK1 and TRAF6 gene and protein expression are significantly higher in CF versus non-CF bronchial epithelial cells while miR-146a expression is significantly lower in CF versus non-CF bronchial epithelial cells. IRAK1 and TRAF6 levels in CFBE41o-cells decreased by ~50% when miR-146a was delivered to these cells using Ribojuice™ while pro-inflammatory IL-8 production in response to LPS was attenuated by 56%. Stable nano-sized, star-miR-146a polyplexes can be formed which are capable of being nebulised and significantly reduce IRAK1 (~50%) protein and IL-8 production (~23%) in CFBEs. Overall a device-integrated, star-miRNA nanoparticle platform has been developed.
[Eisschrunde bei der Brauerei Tiefenbrunnen]
Creators: name: Breitinger, Robert
Publisher: name: [s.n.]
Year: 1891
Subjects: Eisverschluss
Schwimmbad
Zürich

description: Schmelzendes Eis des gefrorenen Zürichsees (Seegfrörni) bei der Brauerei Tiefenbrunnen und der Badeanstalt in der ehemaligen politischen Gemeinde Riesbach, heute Zürich-Riesbach
description: [Robert Breitinger]
description: Auf der Rückseite oben rechts Vermerke in roter Tinte: "1359" (Bildnummer der Kabinettkarte) und "Sys. Posage. roth"? Gemäss dem Verzeichnis Breitingers wurde die Fotografie am 28. Februar 1891 um 15.30 Uhr aufgenommen
description: Im Bestand der Graphischen Sammlung und des Fotoarchivs ist ein ähnlicher Abzug vorhanden (siehe Signatur der Zentralbibliothek Zürich, Graphische Sammlung und Fotoarchiv: Fotosgl. I Seegfrörni 1891)
Proposal for a directive on platform workers: enforcement mechanisms and the potential of the (Italian) certification procedure for self-employment
Creators: name: Giovannone, Maria
Publisher: name: Italian Labour Law e-Journal
Year: 2022

description: In the frame of the draft directive enforcement measures, the essay investigates the advisability of adopting the certification procedure for employment contracts in order to ensure the correct use of genuine self-employment in the digital platform economy. This is a hypothesis evaluated (and discarded) by the European Commission during the consultations for the adoption of the proposal for a directive on platform work. Starting from the implementation criticalities related to the legal presumption and the indices of subordination (Chapter II, proposal for a directive) in national legal systems, the centrality of enforcement mechanisms for verifying the correct contractual qualification is highlighted. However, in addition to the “ex post” enforcement tools, it may be necessary to build “ex ante” verification systems, with a deflationary nature, to be activated at the time of signing the employment contract, especially in the area of self-employment. These considerations are advanced by taking as an example the Italian model of the “Certification Commissions”, in which the European Commission had shown interest.
description: Italian Labour Law e-Journal, Vol. 15 No. 1 (2022)
[Eisschrunde Zürichhorn]
Creators: name: Breitinger, Robert
Publisher: name: [s.n.]
Year: 1891
Subjects: Eisverschluss
Zürich

description: Schmelzendes Eis des gefrorenen Zürichsees (Seegfrörni) im Gebiet des Zürichhorns samt Personen, die auf dem Eis spazieren
description: [Robert Breitinger]
description: Auf der Rückseite oben rechts Vermerk in schwarzer Tinte: "aufgenommen 27. Febr 1891. v. Breitinger Wyder". Gemäss dem Verzeichnis Breitingers wurde die Fotografie am 27. Februar 1891 um 16.00 Uhr aufgenommen
description: In der Sammlung Breitingers ist ein ähnlicher Abzug vorhanden: (siehe Signatur der Zentralbibliothek Zürich, Graphische Sammlung und Fotoarchiv: Breitinger, Cabinet III, Stadt Zürich, Riesbach III/3.8, 1353/76/1891)
[Eisschrunde Zürichhorn]
Creators: name: Breitinger, Robert
Publisher: name: [s.n.]
Year: 1891
Subjects: Eisverschluss
Zürich

description: Schmelzendes Eis des gefrorenen Zürichsees (Seegfrörni) im Gebiet des Zürichhorns samt Personen, die auf dem Eis spazieren
description: [Robert Breitinger]
description: Auf der Rückseite oben rechts Vermerke in roter Tinte: "1353" (Bildnummer der Kabinettkarte) und "?th Rapid Entn[ahme]". Gemäss dem Verzeichnis Breitingers wurde die Fotografie am 27. Februar 1891 um 16.00 Uhr aufgenommen
description: Im Bestand der Graphischen Sammlung und des Fotoarchivs ist ein ähnlicher Abzug vorhanden (siehe Signatur der Zentralbibliothek Zürich, Graphische Sammlung und Fotoarchiv: Fotosgl. I Seegfrörni 1891)
Shigella draft genome sequences : resources for food safety and public health
Creators: name: Weis, Allison M.
name: Brent Gilpin
name: Huang, Bihua C.
name: Kong, Nguyet
name: Chen, Poyin
name: Weimer, Bart C.
Publisher: name: Institute of Environmental Science and Research
Year: 2019
Subjects: Genomics
Genetics not elsewhere classified
Microbial genetics
Microbiology not elsewhere classified
Infectious diseases
Infectious agents

description: Shigella is a major foodborne pathogen that infects humans and nonhuman primates and is the major cause of dysentery and reactive arthritis worldwide. This is the initial public release of 16 Shigella genome sequences from four species sequenced as part of the 100K Pathogen Genome Project.