cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Biharmonic hypersurfaces with three distinct principal curvatures in Euclidean space
Creators: name: Fu, Yu
Publisher: name: arXiv
Year: 2014
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics

description: The well known Chen's conjecture on biharmonic submanifolds states that a biharmonic submanifold in a Euclidean space is a minimal one ([10-13, 16, 18-21, 8]). For the case of hypersurfaces, we know that Chen's conjecture is true for biharmonic surfaces in $\mathbb E^3$ ([10], [24]), biharmonic hypersurfaces in $\mathbb E^4$ ([23]), and biharmonic hypersurfaces in $\mathbb E^m$ with at most two distinct principal curvatures ([21]). The most recent work of Chen-Munteanu [18] shows that Chen's conjecture is true for $δ(2)$-ideal hypersurfaces in $\mathbb E^m$, where a $δ(2)$-ideal hypersurface is a hypersurface whose principal curvatures take three special values: $λ_1, λ_2$ and $λ_1+λ_2$. In this paper, we prove that Chen's conjecture is true for hypersurfaces with three distinct principal curvatures in $\mathbb E^m$ with arbitrary dimension, thus, extend all the above-mentioned results. As an application we also show that Chen's conjecture is true for $O(p)\times O(q)$-invariant hypersurfaces in Euclidean space $\mathbb E^{p+q}$.
description: 18 pages,to appear in Tohoku Math. J
Constructing black hole entropy from gravitational collapse
Creators: name: Acquaviva, Giovanni
name: Ellis, George F. R.
name: Goswami, Rituparno
name: Hamid, Aymen I. M.
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Based on a recent proposal for the gravitational entropy of free gravitational fields, we investigate the thermodynamic properties of black hole formation through gravitational collapse in the framework of the semitetrad 1+1+2 covariant formalism. In the simplest case of an Oppenheimer-Snyder-Datt collapse we prove that the change in gravitational entropy outside a collapsing body is related to the variation of the surface area of the body itself, even before the formation of horizons. As a result, we are able to relate the Bekenstein-Hawking entropy of the black hole endstate to the variation of the vacuum gravitational entropy outside the collapsing body.
description: 8 pages, 1 figure
A prototype U.S. CMS analysis facility
Creators: name: Shadura, Oksana
Publisher: name: Zenodo
Year: 2020

description: In the HL-LHC era, an order of magnitude increase of event rates will mean activities that can be done on a laptop today will require significantly more resources tomorrow. For example, increased dataset volumes means that users cannot necessarily keep all their data locally on a laptop - dedicated analysis facilities will be needed. Today, most facilities are batch-oriented while analysts often want to work interactive when exploring the data; facilities will likely need to provide a hybrid of both batch and interactive approaches going forward. U.S. CMS seeks to provide a prototype analysis facility that addresses these challenges during 2020. In this tutorial we describe and demonstrate elements of such a prototype at the University of Nebraska-Lincoln (UNL). The prototype analysis facility provides services for “low latency columnar analysis”, enabling rapid processing of data in a column-wise fashion. These services, based on Dask and Jupyter notebooks, aim to dramatically lower time for analysis and provide an easily-scalable and user-friendly computational environment that will simplify, facilitate, and accelerate the delivery of HEP results. The facility is built on top of a local Kubernetes cluster and integrates dedicated resources with resources allocated via fairshare through the local HTCondor system. In addition to the user-facing interfaces such as Dask, the facility also manages access control through single-sign-on and authentication & authorization for data access. The showcase will include simple HEP analysis examples, managed interactively in a Jupyter notebook and scheduled on Dask workers and accessing both public and protected data
Side-by-Side vs Face-to-Face: Evaluating Colocated Collaboration via a Transparent Wall-sized Display
Creators: name: Gong, Jiangtao
name: Sun, Jingjing
name: Chu, Mengdi
name: Wang, Xiaoye
name: Luo, Minghai
name: Lu, Yi
name: Zhang, Liuxin
name: Wu, Yaqiang
name: Wang, Qianying
name: Liu, Can
Publisher: name: arXiv
Year: 2023
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: FOS: Computer and information sciences
subject: H.5.2

description: Traditional wall-sized displays mostly only support side-by-side co-located collaboration, while transparent displays naturally support face-to-face interaction. Many previous works assume transparent displays support collaboration. Yet it is unknown how exactly its afforded face-to-face interaction can support loose or close collaboration, especially compared to the side-by-side configuration offered by traditional large displays. In this paper, we used an established experimental task that operationalizes different collaboration coupling and layout locality, to compare pairs of participants collaborating side-by-side versus face-to-face in each collaborative situation. We compared quantitative measures and collected interview and observation data to further illustrate and explain our observed user behavior patterns. The results showed that the unique face-to-face collaboration brought by transparent display can result in more efficient task performance, different territorial behavior, and both positive and negative collaborative factors. Our findings provided empirical understanding about the collaborative experience supported by wall-sized transparent displays and shed light on its future design.
description: 25 pages, 13 figures
Addendum: Improved MSSM Higgs mass calculation using the 3-loop FlexibleEFTHiggs approach including $x_t$-resummation
Creators: name: Kwasnitza, Thomas
name: Stöckinger, Dominik
name: Voigt, Alexander
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In this addendum we present the stand-alone C++ program MSSMEFTHiggs3L, which implements the 3-loop FlexibleEFTHiggs approach to calculate the lightest CP-even Higgs boson pole mass in the real MSSM at N$^3$LL and N$^3$LO with $x_q$ resummation, presented in JHEP 07 (2020) 197 (arXiv:2003.04639).
description: 5 pages, 1 figure
We are all Individuals: The Role of Robot Personality and Human Traits in Trustworthy Interaction
Creators: name: Lim, Mei Yii
name: Lopes, José David Aguas
name: Robb, David A.
name: Wilson, Bruce W.
name: Moujahid, Meriam
name: De Pellegrin, Emanuele
name: Hastie, Helen
Publisher: name: arXiv
Year: 2023
Subjects: subject: Robotics (cs.RO)
subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences
subject: H.5; I.2

description: As robots take on roles in our society, it is important that their appearance, behaviour and personality are appropriate for the job they are given and are perceived favourably by the people with whom they interact. Here, we provide an extensive quantitative and qualitative study exploring robot personality but, importantly, with respect to individual human traits. Firstly, we show that we can accurately portray personality in a social robot, in terms of extroversion-introversion using vocal cues and linguistic features. Secondly, through garnering preferences and trust ratings for these different robot personalities, we establish that, for a Robo-Barista, an extrovert robot is preferred and trusted more than an introvert robot, regardless of the subject's own personality. Thirdly, we find that individual attitudes and predispositions towards robots do impact trust in the Robo-Baristas, and are therefore important considerations in addition to robot personality, roles and interaction context when designing any human-robot interaction study.
description: 8 pages, RO-MAN'22, 31st IEEE International Conference on Robot and Human Interactive Communication (RO-MAN), August 2022, Naples, Italy
Cryo-EM structure of the Smc5/6 holo-complex
Creators: name: Hallett, Stephen T
name: Harry, Isabella Campbell
name: Schellenberger, Pascale
name: Zhou, Lihong
name: Cronin, Nora B
name: Baxter, Jonathan
name: Etheridge, Thomas J
name: Murray, Johanne M
name: Oliver, Antony W
Publisher: name: The Francis Crick Institute
Year: 2022
Subjects: Chemical Biology & High Throughput
Structural Biology & Biophysics

description: The Smc5/6 complex plays an essential role in the resolution of recombination intermediates formed during mitosis or meiosis, or as a result of the cellular response to replication stress. It also functions as a restriction factor preventing viral replication. Here, we report the cryogenic EM (cryo-EM) structure of the six-subunit budding yeast Smc5/6 holo-complex, reconstituted from recombinant proteins expressed in insect cells – providing both an architectural overview of the entire complex and an understanding of how the Nse1/3/4 subcomplex binds to the hetero-dimeric SMC protein core. In addition, we demonstrate that a region within the head domain of Smc5, equivalent to the ‘W-loop’ of Smc4 or ‘F-loop’ of Smc1, mediates an important interaction with Nse1. Notably, mutations that alter the surface-charge profile of the region of Nse1 which accepts the Smc5-loop, lead to a slow-growth phenotype and a global reduction in the chromatin-associated fraction of the Smc5/6 complex, as judged by single molecule localisation microscopy experiments in live yeast. Moreover, when taken together, our data indicates functional equivalence between the structurally unrelated KITE and HAWK accessory subunits associated with SMC complexes.
Global coherence of older adults with traumatic brain injury
Creators: name: Yutrzenka, Melissa
name: Phillips, Emma
name: Byom, Lindsey
name: Li, Jamie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Adults with traumatic brain injury (TBI) may experience communication deficits at the macrolinguistic and microlinguistic levels of discourse. Global coherence is an element of macrolinguistics defined by the speaker’s ability to maintain topic organization and thematic unity. Maintenance of global coherence has been studied amongst neurotypical adults and adults with acquired neurogenic disorders, however little is known about the global coherence of older adults with TBI. This is concerning because older adults are among those most at risk for TBI. The objective of this study was to quantify the degree of global coherence in the discourse of older adults’ with TBI using a 4-point global coherence scale during a narrative story retelling. Based on prior research in younger adults1 we hypothesized that older adults with TBI would produce narratives that were rated as less coherent than those of older adults with no TBI history.
FleXR: A System Enabling Flexibly Distributed Extended Reality
Creators: name: Heo, Jin
name: Bhardwaj, Ketan
name: Gavrilovska, Ada
Publisher: name: arXiv
Year: 2023
Subjects: subject: Distributed, Parallel, and Cluster Computing (cs.DC)
subject: Multimedia (cs.MM)
subject: FOS: Computer and information sciences

description: Extended reality (XR) applications require computationally demanding functionalities with low end-to-end latency and high throughput. To enable XR on commodity devices, a number of distributed systems solutions enable offloading of XR workloads on remote servers. However, they make a priori decisions regarding the offloaded functionalities based on assumptions about operating factors, and their benefits are restricted to specific deployment contexts. To realize the benefits of offloading in various distributed environments, we present a distributed stream processing system, FleXR, which is specialized for real-time and interactive workloads and enables flexible distributions of XR functionalities. In building FleXR, we identified and resolved several issues of presenting XR functionalities as distributed pipelines. FleXR provides a framework for flexible distribution of XR pipelines while streamlining development and deployment phases. We evaluate FleXR with three XR use cases in four different distribution scenarios. In the results, the best-case distribution scenario shows up to 50% less end-to-end latency and 3.9x pipeline throughput compared to alternatives.
description: 11 pages, 11 figures, conference paper
Error Analysis of the Variational Quantum Eigensolver Algorithm
Creators: name: Brandhofer, Sebastian
name: Devitt, Simon
name: Polian, Ilia
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Variational quantum algorithms have been one of the most intensively studied applications for near-term quantum computing applications. The noisy intermediate-scale quantum (NISQ) regime, where small enough algorithms can be run successfully on noisy quantum computers expected during the next 5 years, is driving both a large amount of research work and a significant amount of private sector funding. Therefore, it is important to understand whether variational algorithms are effective at successfully converging to the correct answer in presence of noise. We perform a comprehensive study of the variational quantum eigensolver (VQE) and its individual quantum subroutines. Building on asymptotic bounds, we show through explicit simulation that the VQE algorithm effectively collapses already when single errors occur during a quantum processing call. We discuss the significant implications of this result in the context of being able to run any variational type algorithm without resource expensive error correction protocols.
Real-space grids and the Octopus code as tools for the development of new simulation approaches for electronic systems
Creators: name: Andrade, Xavier
name: Strubbe, David A.
name: De Giovannini, Umberto
name: Larsen, Ask Hjorth
name: Oliveira, Micael J. T.
name: Alberdi-Rodriguez, Joseba
name: Varas, Alejandro
name: Theophilou, Iris
name: Helbig, Nicole
name: Verstraete, Matthieu
name: Stella, Lorenzo
name: Nogueira, Fernando
name: Aspuru-Guzik, Alán
name: Castro, Alberto
name: Marques, Miguel A. L.
name: Rubio, Ángel
Publisher: name: arXiv
Year: 2015
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Other Condensed Matter (cond-mat.other)
subject: Computational Physics (physics.comp-ph)
subject: FOS: Physical sciences

description: Real-space grids are a powerful alternative for the simulation of electronic systems. One of the main advantages of the approach is the flexibility and simplicity of working directly in real space where the different fields are discretized on a grid, combined with competitive numerical performance and great potential for parallelization. These properties constitute a great advantage at the time of implementing and testing new physical models. Based on our experience with the Octopus code, in this article we discuss how the real-space approach has allowed for the recent development of new ideas for the simulation of electronic systems. Among these applications are approaches to calculate response properties, modeling of photoemission, optimal control of quantum systems, simulation of plasmonic systems, and the exact solution of the Schrödinger equation for low-dimensionality systems.
description: 28 pages, 16 figures
Impact of leader on cluster synchronization
Creators: name: Jalan, Sarika
name: Singh, Aradhana
name: Acharya, Suman
name: Kurths, J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: We study the mechanisms of frequency synchronized cluster formation in coupled non-identical oscillators and investigate the impact of presence of a leader on the cluster synchronization. We find that the introduction of a leader, node having large parameter mismatch, induces a profound change in the cluster pattern as well as in the mechanism of the cluster formation. The emergence of a leader generates a transition from the driven to the mixed cluster state. The frequency mismatch turns out to be responsible for this transition. Additionally, for a chaotic evolution, the driven mechanism stands as a primary mechanism for the cluster formation, whereas for a periodic evolution the self-organization mechanism becomes equally responsible.
description: 5 pages, 5 figures
When to generate hedges in peer-tutoring interactions
Creators: name: Abulimiti, Alafate
name: Clavel, Chloé
name: Cassell, Justine
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences

description: This paper explores the application of machine learning techniques to predict where hedging occurs in peer-tutoring interactions. The study uses a naturalistic face-to-face dataset annotated for natural language turns, conversational strategies, tutoring strategies, and nonverbal behaviours. These elements are processed into a vector representation of the previous turns, which serves as input to several machine learning models. Results show that embedding layers, that capture the semantic information of the previous turns, significantly improves the model's performance. Additionally, the study provides insights into the importance of various features, such as interpersonal rapport and nonverbal behaviours, in predicting hedges by using Shapley values for feature explanation. We discover that the eye gaze of both the tutor and the tutee has a significant impact on hedge prediction. We further validate this observation through a follow-up ablation study.
description: In Proceedings of the 16th Annual Conference ub Discourse and Dialogue (SIGDIAL). Sept 11-15, Prague Czechia
Flexural behavior of continuous concrete beams prestressed with bonded and unbonded tendons
Creators: name: Abu-Saibia, Abdulemam K.
Publisher: name: No Publisher Supplied
Year: 2018

description: Post-tensioning techniques have become very popular and a primary method in long spans continuous bridges and other structures due to their excellent performance in controlling cracking and excessive deflection. Moreover, the use of continuous prestressed concrete beams leads to shallower cross-sections, requires less maintenance cost, and enhances the durability of concrete in the negative moment region. Since using post-tensioned unbonded tendon requires particular analysis methods to predict the stress in the unbonded tendon because of the bond lack between the tendon and the adjacent concrete, thus this research presents an analytical approach to estimate the stress in the tendon and provide full-range of load versus deformation at different location of the span length at various load levels. The model used a trussed-beam system in additional to moment and force equilibrium equations to find the unknowns which include the stress in the unbonded tendon, deflection, and neutral axis depth. The analytical part included analyzing and estimating the stress in the unbonded tendon for beams subjected to a third-point and single-point load.The proposed approach was validated with results from the performed beam tests in addition to test data in the literature. The experimental part included 20-ft long continuous High Strength Concrete (HSC) beams post-tensioned internally with bonded and unbonded tendons. The experimental approach included casting, instrumenting, and load testing of 8 continuous span beams at various levels of prestressing and combination of tendons. Various design parameters such as the area of non-prestressed steel in tension at the maximum positive and negative moment locations and effective prestress in the bonded, and unbonded tendons are considered. Both models show a good correlation between predicted and experimental results. Furthermore, the effect of different design parameters on the flexural response was investigated. This study demonstrates that some design parameters have a significant influence on the results while the impact of other variables can be ignored.
Possibility to enhance teraherz emission from intrinsic Josephson junction by external local heating
Creators: name: Asai, Hidehiro
name: Kawabata, Shiro
Publisher: name: arXiv
Year: 2014
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We theoretically propose a practical method for realizing intense terahertz (THz) emission from intrinsic Josephson junctions (IJJs) using an external heat source. An artificial inhomogeneous temperature distribution by the local heating strongly excites the Josephson plasma wave inside IJJs and enhances THz emission power. We show optimum heating conditions for achieving high power THz emission. Our result indicates that local heat control is a powerful method to realize practical solid-state THz-emitters utilizing IJJs.
description: 4 pages, 3 figures
Additional file 5 of Mapping the functional impact of non-coding regulatory elements in primary T cells through single-cell CRISPR screens
Creators: name: Alda-Catalinas, Celia
name: Ibarra-Soria, Ximena
name: Flouri, Christina
name: Gordillo, Jorge Esparza
name: Cousminer, Diana
name: Hutchinson, Anna
name: Sun, Bin
name: Pembroke, William
name: Ullrich, Sebastian
name: Krejci, Adam
name: Cortes, Adrian
name: Acevedo, Alison
name: Malla, Sunir
name: Fishwick, Carl
name: Drewes, Gerard
name: Rapiteanu, Radu
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 5. Review history.
Additional file 1: of Aptamer-Modified Magnetic Nanosensitizer for In Vivo MR Imaging of HER2-Expressing Cancer
Creators: name: Heo, Dan
name: Minhee Ku
name: Kim, Jung-Hoon
name: Jaemoon Yang
name: Jin-Suck Suh
Publisher: name: Figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Figure S1. Physicochemical characterization of Tm80. (a) Absorbance spectra, FT-IR spectra; and (b) 1H-NMR spectra of 3-MPA (black line), T80 (blue line), and Tm80 (red line). Figure S2. Schematics showing the volume of oxygen ionic radius in single FCC unit. Figure S3. Half-life of anti-HER2 aptamer in serum: the half-life of control (non-modified), 3 h; NapdU-modified, 151 h. Figure S4. In vivo MR images of HER2+ tumor mouse model (a) AptHER2-MNS—injected group, (b) WMNC—injected group. Scale bars, 5 mm. Table S1. Relative intensities of in vivo MR images measured from figure 5 and S4 (red solid-lined ROI) (DOCX 1110 kb)
Adapting Multilingual Speech Representation Model for a New, Underresourced Language through Multilingual Fine-tuning and Continued Pretraining
Creators: name: Nowakowski, Karol
name: Ptaszynski, Michal
name: Murasaki, Kyoko
name: Nieuważny, Jagna
Publisher: name: arXiv
Year: 2023
Subjects: subject: Computation and Language (cs.CL)
subject: Machine Learning (cs.LG)
subject: Audio and Speech Processing (eess.AS)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In recent years, neural models learned through self-supervised pretraining on large scale multilingual text or speech data have exhibited promising results for underresourced languages, especially when a relatively large amount of data from related language(s) is available. While the technology has a potential for facilitating tasks carried out in language documentation projects, such as speech transcription, pretraining a multilingual model from scratch for every new language would be highly impractical. We investigate the possibility for adapting an existing multilingual wav2vec 2.0 model for a new language, focusing on actual fieldwork data from a critically endangered tongue: Ainu. Specifically, we (i) examine the feasibility of leveraging data from similar languages also in fine-tuning; (ii) verify whether the model's performance can be improved by further pretraining on target language data. Our results show that continued pretraining is the most effective method to adapt a wav2vec 2.0 model for a new language and leads to considerable reduction in error rates. Furthermore, we find that if a model pretrained on a related speech variety or an unrelated language with similar phonological characteristics is available, multilingual fine-tuning using additional data from that language can have positive impact on speech recognition performance when there is very little labeled data in the target language.
description: 14 pages
Quantum annealing: the fastest route to quantum computation?
Creators: name: Laumann, C. R.
name: Moessner, R.
name: Scardicchio, A.
name: Sondhi, S. L.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: In this review we consider the performance of the quantum adiabatic algorithm for the solution of decision problems. We divide the possible failure mechanisms into two sets: small gaps due to quantum phase transitions and small gaps due to avoided crossings inside a phase. We argue that the thermodynamic order of the phase transitions is not predictive of the scaling of the gap with the system size. On the contrary, we also argue that, if the phase surrounding the problem Hamiltonian is a Many-Body Localized (MBL) phase, the gaps are going to be typically exponentially small and that this follows naturally from the existence of local integrals of motion in the MBL phase.
description: 16 pages, 1 figure
Effect of stimulus type on extended high frequency thresholds
Creators: name: Kane, Stacey
name: Buss, Emily
name: Sobon, Kathryn
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Extended high frequency (EHF) information (≥ 8 kHz) plays a significant role in speech understanding for both adults and children (e.g., Monson et al., 2019; Braza et al., 2021; Flaherty et al., 2021). However, measurement protocols at EHFs are not well established. Detection thresholds above 8 kHz can be highly variable (Plack et al., 2019). Some researchers suggest separate normative
reference values for listeners above and below 18 years old (Hemmingson et al., 2021).
Constraining globular cluster formation through studies of young massive clusters - V. ALMA observations of clusters in the Antennae
Creators: name: Cabrera-Ziri, I.
name: Bastian, N.
name: Longmore, S. N.
name: Brogan, C.
name: Hollyhead, K.
name: Larsen, S. S.
name: Whitmore, B.
name: Johnson, K.
name: Chandar, R.
name: Henshaw, J. D.
name: Davies, B.
name: Hibbard, J. E.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Some formation scenarios that have been put forward to explain multiple populations within Globular Clusters (GCs) require that the young massive cluster have large reservoirs of cold gas within them, which is necessary to form future generations of stars. In this paper we use deep observations taken with Atacama Large Millimeter/sub-millimeter Array (ALMA) to assess the amount of molecular gas within 3 young (50-200 Myr) massive (~10^6 Msun) clusters in the Antennae galaxies. No significant CO(3--2) emission was found associated with any of the three clusters. We place upper limits for the molecular gas within these clusters of ~1x10^5 Msun (or <9 % of the current stellar mass). We briefly review different scenarios that propose multiple episodes of star formation and discuss some of their assumptions and implications. Our results are in tension with the predictions of GC formation scenarios that expect large reservoirs of cool gas within young massive clusters at these ages.
description: 9 pages, 2 figures, accepted by MNRAS
Additional file 1: of Aptamer-modified Magnetic Nanosensitizer for in vivo MR imaging of HER2-expressing Cancer
Creators: name: Heo, Dan
name: Minhee Ku
name: Kim, Jung-Hoon
name: Jaemoon Yang
name: Jin-Suck Suh
Publisher: name: Figshare
Year: 2018
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Figure S1. Physicochemical characterization of Tm80. (a) Absorbance spectra, FT-IR spectra; and (b) 1H-NMR spectra of 3-MPA (black line), T80 (blue line), and Tm80 (red line). Figure S2. Schematics showing the volume of oxygen ionic radius in single FCC unit. Figure S3. Half-life of anti-HER2 aptamer in serum: the half-life of control (non-modified), 3 h; NapdU-modified, 151 h. Figure S4. In vivo MR images of HER2+ tumor mouse model (a) AptHER2-MNS—injected group, (b) WMNC—injected group. Scale bars, 5 mm. Table S1. Relative intensities of in vivo MR images measured from figure 5 and S4 (red solid-lined ROI) (DOCX 1110 kb)
Pair creation in heavy ion channeling
Creators: name: Belov, Nikolay A.
name: Harman, Zoltán
Publisher: name: arXiv
Year: 2014
Subjects: subject: Atomic Physics (physics.atom-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Heavy ions channeling through crystals with multi-GeV kinetic energies can create electron-positron pairs. In the framework of the ion, the energy of virtual photons arising from the periodic crystal potential may exceed the threshold $2mc^2$. The repeated periodic collisions with the crystal ions yield high pair production rates. When the virtual photon frequency matches a nuclear transition in the ion, the production rate can be resonantly increased. In this two-step excitation-pair conversion scheme, the excitation rates are coherently enhanced, and they scale approximately quadratically with the number of crystal sites along the channel.
ENSURING NATIONAL ECONOMIC SECURITY IN THE CONDITIONS OF GREEN ECONOMY DEVELOPMENT IN UZBEKISTAN
Creators: name: Rustamova, Maftuna
Publisher: name: Zenodo
Year: 2023

description: This research explores the vital topic of ensuring national economic security within the context of Uzbekistan's burgeoning green economy. As environmental concerns grow globally, nations are transitioning toward sustainable practices, posing unique challenges and opportunities for economic security. This study investigates Uzbekistan's strategies, policies, and challenges in aligning economic growth with ecological sustainability, ensuring a harmonious development path. The research delves into various aspects, from renewable energy adoption to sustainable agriculture, providing insights into how Uzbekistan navigates the complexities of the green economy to safeguard its economic stability.
Concurrent recording of the electrically-evoked compound action potential and the auditory brainstem response in cochlear implant users
Creators: name: Dillon, Margaret
name: Dedmon, Matthew M.
name: Van Bosch, Jenna
name: Grose, John H.
name: Kane, Stacey G.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2022

description: Purpose and Technological Feasibility
• In the ABR waveform, WI reflects activity in the 8th cranial nerve while WV reflects activity in the upper brainstem. The amplitude ratio between WI and WV is emerging as an important metric for auditory function.
• In the electrically evoked ABR (eABR), eWI cannot be measured because of artifact associated with cochlear implant (CI) stimulation. The electrical eWI /eWV ratio therefore cannot be measured in a single test as the WI /WV ratio can for an acoustically evoked ABR.
• For MED-EL Corporation CIs, the electrically evoked compound action
potential (eCAP), equivalent to eWI, is measured with the Auditory nerve Response Telemetry (ART) test. The ART uses sequences of ‘masker’ and ‘probe’ biphasic pulses to extract an eCAP (see Fig. 1). Note that the ART also generates an external trigger.
Additional file 1 of Natural carboxyterminal truncation of human CXCL10 attenuates glycosaminoglycan binding, CXCR3A signaling and lymphocyte chemotaxis, while retaining angiostatic activity
Creators: name: Dillemans, Luna
name: Yu, Karen
name: De Zutter, Alexandra
name: Noppen, Sam
name: Gouwy, Mieke
name: Berghmans, Nele
name: Verhallen, Lisa
name: De Bondt, Mirre
name: Vanbrabant, Lotte
name: Brusselmans, Stef
name: Martens, Erik
name: Schols, Dominique
name: Verschueren, Patrick
name: Rosenkilde, Mette M.
name: Marques, Pedro Elias
name: Struyf, Sofie
name: Proost, Paul
Publisher: name: figshare
Year: 2024
Subjects: subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 1: Figure S1. (related to Figure 1) shows the experimental optimization of the solid phase peptide synthesis of human CXCL10(1-73). Figure S2. (related to Figure 2) demonstrates the fitted curves on SPR sensorgrams for interactions of heparin, heparan sulfate and chondroitin sulfate via the 1:1 binding model with mass transfer correction. Figure S3. (related to Figure 3H-I) shows the gating strategy for evaluation of CXCR3 expression on primary T lymphocytes stimulated with phytohemagglutinin (PHA) and IL-2. Figure S4. (related to Figure 3) shows that CXCL10(1-73) also induces significantly less T lymphocyte migration through membranes coated with different extracellular matrix proteins compared to CXCL10(1-77). Figure S5. (related to Figure 5) shows high quality images of the wound borders and area with reduced wound density upon treatment with CXCL10(1-77) and CXCL10(1-73). Figure S6. (related to Figure 5) shows that FGF-2-induced HMVEC migration and invasion is inhibited by CXCL10(1-77) and CXCL10(1-73) at 360 nM. Figure S7. (related to Figure 7) shows that the average consumption of sitagliptin per mouse is equivalent for groups that were treated with vehicle, CXCL10(1-77) or CXCL10(1-73). Figure S8. (related to Figure 7) shows that trends towards increased ingress of T cells, CD4+ T cells, NKT cells and B cells and their activated CXCR3+ subsets were found for mice treated with CXCL10(1-77), but not for those receiving CXCL10(1-73). Figure S9. (related to Figure 5-8) shows that CXCL10(1-77) and CXCL10(1-73) do not affect the expression of adherence junction vascular endothelial (VE)-cadherin nor tight junction zona occludens 1 (ZO-1). This figure also shows the CXCR3 expression by HMVEC and CXCR3A-transfected CHO cells in culture. Table S1. (related to Figure 3E and Figure 3H-I) shows the list of antibodies used for immunophenotyping of CXCR3-expressing primary T lymphocytes stimulated with PHA and IL-2. Table S2. (related to Figure 7) shows a list of the antibodies used for immunophenotyping of peritoneal lymphoid cells harvested after peritoneal lavages from sitagliptin-treated NMRI mice. Table S3. (related to Figure 8) shows a list of the antibodies used for immunophenotyping of endothelial cells to evaluate lymphocyte adhesion molecules, adherence and tight junctions.
On the ontological ambiguity of Physics facing Reality
Creators: name: Horvath, J. E.
name: Fernandes, R. Rosas
name: Idiart, T. E.
Publisher: name: arXiv
Year: 2023
Subjects: subject: History and Philosophy of Physics (physics.hist-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We discuss in this work the contradictory position in modern Physics between the existence of a microphysical quantum Reality and macrophysical classical one. After discussing some basic concepts in Philosophy, we revisit the situation of Quantum Mechanics results, particularly after the confirmation of violations of Bell's Theorem, and its significance to create a tension between the micro and the macro world, which is very fundamental and unsolved.
description: Contribution to the IWARA 2022 Workshop, Antigua, Guatemala
Dynamical Stability of a Many-body Kapitza Pendulum
Creators: name: Citro, Roberta
name: Torre, Emanuele G. Dalla
name: DÁlessio, Luca
name: Polkovnikov, Anatoli
name: Babadi, Mehrtash
name: Oka, Takashi
name: Demler, Eugene
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We consider a many-body generalization of the Kapitza pendulum: the periodically-driven sine-Gordon model. We show that this interacting system is dynamically stable to periodic drives with finite frequency and amplitude. This finding is in contrast to the common belief that periodically-driven unbounded interacting systems should always tend to an absorbing infinite-temperature state. The transition to an unstable absorbing state is described by a change in the sign of the kinetic term in the effective Floquet Hamiltonian and controlled by the short-wavelength degrees of freedom. We investigate the stability phase diagram through an analytic high-frequency expansion, a self-consistent variational approach, and a numeric semiclassical calculations. Classical and quantum experiments are proposed to verify the validity of our results.
description: 11 pages, 11 figures
Early life influences of pharmacological and immune stressors on development
Creators: name: Norton, Sara A.
Publisher: name: No Publisher Supplied
Year: 2019

description: Neurodevelopmental disorders manifest early and may impair function throughout life. Exposure to environmental challenges is thought to play a causal role in many such disorders, but a key unanswered question relates to the vulnerability window(s) during which there is an increased sensitivity to these challenges. In a mouse model, we found that administration of the GABAergic toxicant valproic acid (VPA) differentially disrupted neurobehavioral development depending on the precise timing of exposure, and that the resulting behavioral profiles were sex-dependent. Specifically, neonatal C57BL/6 mice were challenged with 400 mg/kg VPA or saline on postnatal day 14 (P14) or 300 mg/kg VPA or saline on postnatal day 7 (P7). Animals were then assessed on a battery of behavioral tests chosen to assess social, emotional, and cognitive functioning. While VPA exposure at P14 resulted in a behaviorally disinhibited phenotype in males, VPA exposure at P7 resulted in social abnormalities in females. In addition, a single VPA challenge at either P7 or P14 affected dendritic spine plasticity in brain regions thought to regulate behaviors that reflect impulsivity. Finally, the behavioral consequences of VPA challenge were compared with an immunogenic challenge using the T cell superantigen, staphylococcal enterotoxin A (SEA). Challenge with SEA at P7 and P14 revealed that interleukin-2 (IL-2) production was lacking at P7, but not P14. Therefore, behavior was investigated after P14 treatment. There were no major differences in social, emotional or cognitive behaviors between SEA- and saline-treated mice during adolescence or adulthood. Overall, this investigation revealed that pharmacological challenges that focus on disruption of the GABAergic system influenced neurodevelopment in a sex- and time-dependent manner. However, T cell immune challenge was less disruptive, possibly due to the absence of key neuromodulatory cytokines that are normally induced by SEA in adult rodents and by other proinflammatory stimuli that target non-T cell populations. In conclusion, identifying the approximate vulnerability windows during postnatal development may allow for a better understanding of underlying mechanisms resulting in toxicant-induced deficits and provide a focus for prevention efforts.
Theory of reactions between hydrogen and group-III acceptors in silicon
Creators: name: Coutinho, José
name: Gomes, Diana
name: Torres, Vitor J. B.
name: Fattah, Tarek O. Abdul
name: Markevich, Vladimir P.
name: Peaker, Anthony R.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The thermodynamics of several reactions involving atomic and molecular hydrogen with group-III acceptors is investigated. The results provide a first-principles-level account of thermally- and carrier-activated processes involving these species. Acceptor-hydrogen pairing is revisited as well. We present a refined physicochemical picture of long-range migration, compensation effects, and short-range reactions, leading to fully passivated $\equiv\textrm{Si-H}\cdots X\equiv$ structures, where $X$ is a group-III acceptor element. The formation and dissociation of acceptor-H and acceptor-H$_{2}$ complexes is considered in the context of Light and elevated Temperature Induced Degradation (LeTID) of silicon-based solar cells. Besides explaining observed trends and answering several fundamental questions regarding the properties of acceptor-hydrogen pairing, we find that the BH$_{2}$ complex is a by-product along the reaction of H$_{2}$ molecules with boron toward the formation of BH pairs (along with subtraction of free holes). The calculated changes in Helmholtz free energies upon the considered defect reactions, as well as activation barriers for BH$_{2}$ formation/dissociation (close to $\sim1$ eV) are compatible with the experimentally determined activation energies of degradation/recovery rates of Si:B-based cells during LeTID. Dihydrogenated acceptors heavier than boron are anticipated to be effective-mass-like shallow donors, and therefore, unlikely to show similar non-radiative recombination activity.
In Defense of Elizabethan Anglicanism: The Virginia Company of London
Creators: name: Lukow, Jamie
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2021

description: When observing the origins of the Virginia Company, historians tend to underappreciate the significance that Anglicanism had for the Company’s endeavors. The Virginia Company was a platform for contemporary writers like Edwin Sandys, Nicholas Ferrar, and John Donne to shape what they considered to be a never-before-seen comprehensive form of Anglicanism which had only been suggested in theory in the Elizabethan Religious Settlement of 1559. What is more, Jamestown served a diverse group of European Christians and established Virginia as a religious polity in the New World while religious wars continued to plague the Old World.
Supplemental Material for Martin, Chruscick, and Howe, 2018
Creators: name: Martin, Benjamin J. E.
name: Chruscick, Adam T.
name: Howe, LeAnn J.
Publisher: name: Figshare
Year: 2018
Subjects: subject: 60405 Gene Expression (incl. Microarray and other genome-wide approaches)
subject: FOS: Biological sciences
subject: Molecular Biology

description: Ten supplemental figures.
Bimodal logics with a `weakly connected' component without the finite model property
Creators: name: Kurucz, Agi
Publisher: name: arXiv
Year: 2015
Subjects: subject: Logic in Computer Science (cs.LO)
subject: Logic (math.LO)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: There are two known general results on the finite model property (fmp) of commutators [L,L'] (bimodal logics with commuting and confluent modalities). If L is finitely axiomatisable by modal formulas having universal Horn first-order correspondents, then both [L,K] and [L,S5] are determined by classes of frames that admit filtration, and so have the fmp. On the negative side, if both L and L' are determined by transitive frames and have frames of arbitrarily large depth, then [L,L'] does not have the fmp. In this paper we show that commutators with a `weakly connected' component often lack the fmp. Our results imply that the above positive result does not generalise to universally axiomatisable component logics, and even commutators without `transitive' components such as [K.3,K] can lack the fmp. We also generalise the above negative result to cases where one of the component logics has frames of depth one only, such as [S4.3,S5] and the decidable product logic S4.3xS5. We also show cases when already half of commutativity is enough to force infinite frames.
Something new about radial wave functions of fermions in the repulsive Coulomb field
Creators: name: Neznamov, V. P.
name: Safronov, I. I.
name: Shemarulin, V. E.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: An impermeable barrier at $r=r_{cl}$ in the effective potential of the relativistic Schrödinger-type equation leads to exclusion of the range $0 \leq r < r_{cl}$ from the wave function domain. Based on duality of the Schrödinger-type equation and the Dirac equation, a similar exclusion should be made in the wave functions domain of the Dirac equation. As a result, we obtain new solutions to the Dirac equation in the Coulomb repulsive field. Calculations show that depending on working parameters, at distances of several fractions or units of the Compton wavelength of the fermion from $r=r_{cl}$ new solutions almost coincide with the standard Coulomb functions of the continuous spectrum. Practically, matrix elements with new solutions will coincide to a good accuracy with standard matrix elements with the Coulomb functions of the continuous spectrum. Our consideration is methodological and helpful for discussing further development of quantum theory.
description: 21 pages, 11 figures
Comparing OTC hearing aid outcomes in adults (Swanepoel et al., 2023)
Creators: name: Swanepoel, De Wet
name: Oosthuizen, Ilze
name: Graham, Marien Alet
name: Manchaiah, Vinaya
Publisher: name: ASHA journals
Year: 2023
Subjects: classificationCode: 420102
subject: Audiology
classificationCode: 470102
subject: Communication technology and digital media studies

description: Purpose: More affordable hearing aids are now available due to over-the-counter (OTC) hearing aid regulations. Although laboratory studies have validated many OTC hearing technologies, there are limited real-world benefit studies. This study compared hearing aid outcomes reported by clients from OTC and conventional hearing care professional (HCP) service delivery models.Method: An ecological, cross-sectional survey design was employed. An online survey was sent to the Hearing Tracker user and OTC Lexie hearing aid user databases. Moreover, 656 hearing aid users completed the survey—406 through conventional HCP services (Mage = 66.7 ± 13.0 years) and 250 through the OTC model (Mage = 63.7 ± 12.2 years). Self-reported hearing aid benefit and satisfaction were measured with the International Outcome Inventory for Hearing Aids outcome tool.Results: No significant difference for overall hearing aid outcomes between HCP and OTC users was evident using regression analyses, controlling for age, gender, duration of hearing loss, duration before hearing aid purchase, self-reported hearing difficulty, and unilateral versus bilateral fitting. For the “daily use” domain, HCP clients reported significantly longer hours of daily use. For the “residual activity limitations” domain, OTC hearing aid users reported significantly less difficulty hearing in situations where they most wanted to hear better.Conclusions: OTC hearing aid outcomes could complement and provide similar satisfaction and benefit to HCP models for adults. Service delivery aspects such as self-fitting, acclimatization programs, remote support, behavioral incentivization, and payment options should be investigated for their potential role in OTC hearing aid outcomes.Supplemental Material S1. Checklist for Reporting Of Survey Studies (CROSS; Sharma et al., 2021).Supplemental Material S2. Hearing aid experiences survey.Swanepoel, D. W., Oosthuizen, I., Graham, M. A., & Manchaiah, V. (2023). Comparing hearing aid outcomes in adults using over-the-counter and hearing care professional service delivery models. American Journal of Audiology, 32(2), 314–322. https://doi.org/10.1044/2022_AJA-22-00130