title: Toll-Ð¿Ð¾Ð´Ð¾Ð±Ð½ÑÐµ ÑÐµÑÐµÐ¿ÑÐ¾ÑÑ Ð¿ÑÐ¸ Ð³ÑÐ°Ð½ÑÐ»ÐµÐ¼Ð°ÑÐ¾Ð·Ð½Ð¾Ð¼ Ð²Ð¾ÑÐ¿Ð°Ð»ÐµÐ½Ð¸Ð¸
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: Toll-like receptors in granulomatous inflammation
Creators: name: ÐÑÑÐ¸Ð½Ð°, Ð¯Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2023
Subjects: Toll-Ð¿Ð¾Ð´Ð¾Ð±Ð½ÑÐµ ÑÐµÑÐµÐ¿ÑÐ¾ÑÑ
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ÑÑÐµÐ¿ÐµÐ½Ð¸ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ð°
ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ñ Ð±ÐµÐ»ÐºÐ¾Ð²
Toll-like receptors
membrane and intracellular receptors
adaptive and innate immunity
inflammatory process
immunohistochemistry
granuloma
tuberculosis
tuberculoma
degrees of tuberculosis activity
protein expression

description: ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸Ð·ÑÑÐµÐ½Ð¸Ñ Toll-Ð¿Ð¾Ð´Ð¾Ð±Ð½ÑÑ ÑÐµÑÐµÐ¿ÑÐ¾ÑÐ¾Ð² Ð¸ Ð¸Ñ ÑÐ¾Ð»Ð¸ Ð² Ð²Ð¾ÑÐ¿Ð°Ð»Ð¸ÑÐµÐ»ÑÐ½ÑÑ Ð¿ÑÐ¾ÑÐµÑÑÐ°Ñ, Ð°Ð´Ð°Ð¿ÑÐ¸Ð²Ð½Ð¾Ð¼ Ð¸ Ð²ÑÐ¾Ð¶Ð´ÐµÐ½Ð½Ð¾Ð¼ Ð¸Ð¼Ð¼ÑÐ½Ð¸ÑÐµÑÐµ, Ð² ÑÐ°ÑÑÐ½Ð¾ÑÑÐ¸ ÑÑÐ°ÑÑÐ¸Ðµ ÑÐµÑÐµÐ¿ÑÐ¾ÑÐ¾Ð² Ð² ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ð¸ Ð³ÑÐ°Ð½ÑÐ»ÐµÐ¼Ð°ÑÐ¾Ð·Ð½Ð¾Ð³Ð¾ Ð²Ð¾ÑÐ¿Ð°Ð»ÐµÐ½Ð¸Ñ, ÑÐ°Ð·Ð²Ð¸Ð²Ð°ÑÑÐµÐ³Ð¾ÑÑ Ð¿ÑÐ¸ ÑÑÐ±ÐµÑÐºÑÐ»ÑÐ·Ðµ Ð¾ÑÐ³Ð°Ð½Ð¾Ð² Ð´ÑÑÐ°ÑÐµÐ»ÑÐ½Ð¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ. Ð ÑÐ¾Ð´Ðµ ÑÐ°Ð±Ð¾ÑÑ Ð±ÑÐ» Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½ ÑÑÐ¾Ð²ÐµÐ½Ñ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð±ÐµÐ»ÐºÐ¾Ð² TLR1 Ð¸ TLR2 Ð² Ð»ÐµÐ³Ð¾ÑÐ½ÑÑ ÑÐºÐ°Ð½ÑÑ, Ð²Ð·ÑÑÑÑ Ñ Ð¿Ð°ÑÐ¸ÐµÐ½ÑÐ¾Ð² Ñ ÑÐ°Ð·Ð½Ð¾Ð¹ ÑÑÐµÐ¿ÐµÐ½ÑÑ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÑÑÐ±ÐµÑÐºÑÐ»ÑÐ·Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¾ÑÐµÑÑÐ°. Ð ÑÐ¾Ð´Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸Ð»Ð¾ÑÑ Ð¸Ð¼Ð¼ÑÐ½Ð¾Ð³Ð¸ÑÑÐ¾ÑÐ¸Ð¼Ð¸ÑÐµÑÐºÐ¾Ðµ Ð¾ÐºÑÐ°ÑÐ¸Ð²Ð°Ð½Ð¸Ðµ Ð³Ð¸ÑÑÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ñ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ¾Ð², ÑÐ¾Ð´ÐµÑÐ¶Ð°ÑÐ¸Ñ Ð³ÑÐ°Ð½ÑÐ»ÐµÐ¼Ñ, ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ¼Ñ Ð¸ Ð¾ÐºÑÑÐ¶Ð°ÑÑÐ¸Ðµ Ð¸Ñ ÑÐºÐ°Ð½Ð¸ Ð»ÐµÐ³ÐºÐ¾Ð³Ð¾, Ð°Ð½ÑÐ¸ÑÐµÐ»Ð°Ð¼Ð¸ Ðº ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²ÑÑÑÐ¸Ð¼ Ð±ÐµÐ»ÐºÐ°Ð¼. ÐÑÐ¸ Ð°Ð½Ð°Ð»Ð¸Ð·Ðµ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÑ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÐ¾Ð² Ð·Ð°ÑÐµÐ³Ð¸ÑÑÑÐ¸ÑÐ¾Ð²Ð°Ð½Ð¾ ÑÐ²ÐµÐ»Ð¸ÑÐµÐ½Ð¸Ðµ Ð¼ÐµÐ´Ð¸Ð°Ð½Ð½Ð¾Ð³Ð¾ Ð·Ð½Ð°ÑÐµÐ½Ð¸Ñ Ð¾ÑÐ½Ð¾ÑÐ¸ÑÐµÐ»ÑÐ½Ð¾Ð¹ Ð¿Ð»Ð¾ÑÐ°Ð´Ð¸ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ TLR2 Ð¿ÑÐ¸ 3 ÑÑÐµÐ¿ÐµÐ½Ð¸ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÑÑÐ±ÐµÑÐºÑÐ»ÐµÐ·Ð½Ð¾Ð³Ð¾ Ð¿ÑÐ¾ÑÐµÑÑÐ° Ð²Ð½ÑÑÑÐ¸ Ð³ÑÐ°Ð½ÑÐ»ÐµÐ¼Ñ. ÐÐ¾Ð»ÑÑÐµÐ½Ð½ÑÐµ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¿Ð¾Ð´ÑÐ²ÐµÑÐ¶Ð´Ð°ÑÑ Ð²Ð¾Ð²Ð»ÐµÑÐµÐ½Ð½Ð¾ÑÑÑ TLR2 Ð² ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ðµ Ð¸Ð¼Ð¼ÑÐ½Ð½ÑÑ ÑÐµÐ°ÐºÑÐ¸Ð¹ Ð¸ ÑÑÐ°ÑÑÐ¸Ðµ Ð² ÑÐ¾ÑÐ¼Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ð¸ Ð¸ Ð¿Ð°ÑÐ¾Ð³ÐµÐ½ÐµÐ·Ðµ Ð³ÑÐ°Ð½ÑÐ»ÑÐ¼Ñ.Â  ÐÑÐ¾Ð¼Ðµ ÑÐ¾Ð³Ð¾, Ð±ÑÐ»Ð¾ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð½Ð¾ ÑÑÐ°ÑÐ¸ÑÑÐ¸ÑÐµÑÐºÐ¸ Ð´Ð¾ÑÑÐ¾Ð²ÐµÑÐ½Ð¾Ðµ ÑÐ½Ð¸Ð¶ÐµÐ½Ð¸Ðµ ÑÑÐ¾Ð²Ð½Ñ Ð¼ÐµÐ´Ð¸Ð°Ð½Ð½Ð¾Ð³Ð¾ Ð·Ð½Ð°ÑÐµÐ½Ð¸Ñ Ð¾ÑÐ½Ð¾ÑÐ¸ÑÐµÐ»ÑÐ½Ð¾Ð¹ Ð¿Ð»Ð¾ÑÐ°Ð´Ð¸ ÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ TLR2 Ð¿ÑÐ¸ Ð¿ÐµÑÐµÑÐ¾Ð´Ðµ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ñ Ðº ÑÑÐ°Ð´Ð¸Ð¸ ÑÐ°Ð·ÑÐµÑÐµÐ½Ð¸Ñ, ÑÐ¾ ÐµÑÑÑ Ð¿ÑÐ¸ ÑÐ¼ÐµÐ½ÑÑÐµÐ½Ð¸Ð¸ Ð²Ð¾ÑÐ¿Ð°Ð»ÐµÐ½Ð¸Ñ.
description: This work is devoted to the study of Toll-like receptors and their role in inflammatory processes, adaptive and innate immunity, in particular, the participation of receptors in the development of granulomatous inflammation developing in tuberculosis of the respiratory system. In the course of the study, the level of expression of TLR1 and TLR2 proteins in lung tissues taken from patients with varying degrees of activity of the tuberculosis process was determined. During the study, immunohistochemical staining of histological preparations containing granulomas, tuberculomas and surrounding lung tissues with antibodies to the corresponding proteins was carried out. When analyzing the results obtained, an increase in the median value of the relative area of TLR2 expression was registered at the third degree of activity of the tuberculosis process inside the granuloma. The obtained results confirm the involvement of TLR2 in the development of immune reactions and participation in the formation and pathogenesis of granuloma. In addition, a statistically significant decrease in the level of the median value of the relative area of TLR2 expression was shown during the transition of the disease to the resolution stage, that is, with a decrease in inflammation.