cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: AIAS – AI-gestütztes akademisches Schreiben
title: Neue Wege für die Geistes-, Kultur- und Humanwissenschaften
titleType: AlternativeTitle
Creators: name: Zöllner, Reinhard
Publisher: name: Universität Bonn, Institut für Orient- und Asienwissenschaften, Abteilung für Japanologie und Koreanistik
Year: 2024
Subjects: subject: Künstliche Intelligenz
subject: AI
subject: KI
subject: Studium
subject: Lehre
subject: ddc:004
subject: ddc:020
subject: ddc:370

description: Die Studie gibt einen Überblick über Risiken und Chancen der Anwendung künstlicher Intelligenz im Kontext des akademischen Schreibens und entwirft eine Gesamtstrategie zur Einführung des AI-gestützten akademischen Schreibens (AIAS) vor, gegliedert in die Aufgaben und Probleme der Leitungs-, operativen und pädagogischen Ebene. Zwei Einzelmaßnahme zur Absicherung von AIAS, nämlich das Logbuch und das elektronische Portfolio, werden vorgestellt. Im letzten Kapitel wird entworfen, wie der Schreibprozeß unter AIAS konkret aussehen kann.
Patient-reported outcomes - harnessing patients' voices to improve clinical care
Creators: name: Basch, E.
Publisher: name: Massachussetts Medical Society
Year: 2017

description: Symptom management is a cornerstone of clinical care, particularly for patients with chronic conditions. Yet patients’ symptoms and physical impairments go undetected by health care providers as much as half the time, particularly between clinic visits. As a result, we miss opportunities to intervene and alleviate suffering. Moreover, incomplete documentation of this information in the electronic health record (EHR) limits our ability to understand key patient outcomes when we aggregate EHR data for comparative effectiveness research or quality-of-care assessments.
Supplementary document for Ultra-broadband and high-efficiency Planar Chiral Metamaterial - 6099761.pdf
Creators: name: Hussain, Shahid
name: Liu, Qingquan
name: Maroof, Zubaria
name: Ji, Ruonan
name: Wang, Shao-Wei
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Supplement 1
Overcoming barriers to integrating patient-reported outcomes in clinical practice and electronic health records
Creators: name: Basch, E.
name: Snyder, C.
Publisher: name: Oxford University Press
Year: 2017

description: There is burgeoning interest in integrating electronic patient-reported outcomes (PROs) into the workflow of routine cancer care. In general, this involves offering patients an interface for self-reporting their symptoms, distress, physical functioning, and other clinically oriented information through online or telephone systems, with this information conveyed to clinicians through real-time alerts and longitudinal graphic reports.
The Oncology Care Model: Perspectives From the Centers for Medicare & Medicaid Services and Participating Oncology Practices in Academia and the Community
Creators: name: Adelson, K.
name: Kirshner, J.J.
name: Kline, R.
name: Conway, P.H.
name: Basch, E.
name: Devita, M.
name: Strawbridge, L.M.
name: Sinanis, N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Cancer care delivery in the United States is often fragmented and inefficient, imposing substantial burdens on patients. Costs of cancer care are rising more rapidly than other specialties, with substantial regional differences in quality and cost. The Centers for Medicare & Medicaid Services (CMS) Innovation Center (CMMIS) recently launched the Oncology Care Model (OCM), which uses payment incentives and practice redesign requirements toward the goal of improving quality while controlling costs. As of March 2017, 190 practices were participating, with approximately 3,200 oncologists providing care for approximately 150,000 unique beneficiaries per year (approximately 20% of the Medicare Fee-for-Service population receiving chemotherapy for cancer). This article provides an overview of the program from the CMS perspective, as well as perspectives from two practices implementing OCM: an academic health system (Yale Cancer Center) and a community practice (Hematology Oncology Associates of Central New York). Requirements of OCM, as well as implementation successes, challenges, financial implications, impact on quality, and future visions, are provided from each perspective.
$\text{TT}^{\Box}_{\mathcal C}$: a Family of Extensional Type Theories with Effectful Realizers of Continuity
Creators: name: Cohen, Liron
name: Rahli, Vincent
Publisher: name: arXiv
Year: 2023
Subjects: subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences

description: $\text{TT}^{\Box}_{\mathcal C}$ is a generic family of effectful, extensional type theories with a forcing interpretation parameterized by modalities. This paper identifies a subclass of $\text{TT}^{\Box}_{\mathcal C}$ theories that internally realizes continuity principles through stateful computations, such as reference cells. The principle of continuity is a seminal property that holds for a number of intuitionistic theories such as System T. Roughly speaking, it states that functions on real numbers only need approximations of these numbers to compute. Generally, continuity principles have been justified using semantical arguments, but it is known that the modulus of continuity of functions can be computed using effectful computations such as exceptions or reference cells. In this paper, the modulus of continuity of the functionals on the Baire space is directly computed using the stateful computations enabled internally in the theory.
Rewriting and Completeness of Sum-Over-Paths in Dyadic Fragments of Quantum Computing
Creators: name: Vilmart, Renaud
Publisher: name: arXiv
Year: 2023
Subjects: subject: Logic in Computer Science (cs.LO)
subject: Quantum Physics (quant-ph)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: The "Sum-Over-Paths" formalism is a way to symbolically manipulate linear maps that describe quantum systems, and is a tool that is used in formal verification of such systems. We give here a new set of rewrite rules for the formalism, and show that it is complete for "Toffoli-Hadamard", the simplest approximately universal fragment of quantum mechanics. We show that the rewriting is terminating, but not confluent (which is expected from the universality of the fragment). We do so using the connection between Sum-over-Paths and graphical language ZH-calculus, and also show how the axiomatisation translates into the latter. We provide generalisations of the presented rewrite rules, that can prove useful when trying to reduce terms in practice, and we show how to graphically make sense of these new rules. We show how to enrich the rewrite system to reach completeness for the dyadic fragments of quantum computation, used in particular in the Quantum Fourier Transform, and obtained by adding phase gates with dyadic multiples of $π$ to the Toffoli-Hadamard gate-set. Finally, we show how to perform sums and concatenation of arbitrary terms, something which is not native in a system designed for analysing gate-based quantum computation, but necessary when considering Hamiltonian-based quantum computation.
description: arXiv admin note: text overlap with arXiv:2205.02600
Self-adaptive fine-tuning of deep learning super-resolution microscopy for artifact suppression in live-cell imaging
Creators: name: Zhao, Xian'ao
name: Yang, Tianjie
name: Ji, Wei
Publisher: name: figshare
Year: 2025
Subjects: classificationCode: 310199
subject: Biochemistry and cell biology not elsewhere classified

description: Existing pre-trained super-resolution models often struggle to adapt to changes in imaging conditions, leading to artifacts in live-cell imaging. In this study, we introduce an innovative online fine-tuning method specifically designed for deep-learning super-resolution microscopy (DSRM). This approach minimizes artifacts in live-cell imaging by dynamically adjusting model parameters based on data obtained directly from live-cell observations. We applied this method in single-molecule localization microscopy (SMLM)-enabled DSRM, successfully visualizing nanoscale organelle interactions with significantly reduced artifacts.
Feasibility and acceptability of electronic symptom surveillance with clinician feedback using the patient-reported outcomes version of common terminology criteria for adverse events (PRO-CTCAE) in Danish prostate cancer patients
Creators: name: Johansen, C.
name: Dalton, S.O.
name: Hjollund, N.H.
name: Pappot, H.
name: Mitchell, S.A.
name: Nissen, A.
name: Basch, E.
name: Bidstrup, P.E.
name: Baeksted, C.
Publisher: name: Springer
Year: 2017

description: Background: The aim was to examine the feasibility, acceptability and clinical utility of electronic symptom surveillance with clinician feedback using a subset of items drawn from the Patient-Reported Outcomes version of Common Terminology Criteria for Adverse Events (PRO-CTCAE) in a cancer treatment setting. Methods: Danish-speaking men with castration-resistant metastatic prostate cancer receiving treatment at the Department of Oncology, Rigshospitalet, Copenhagen between March 9, 2015 and June 8, 2015 were invited to participate (n = 63 eligible). Participants completed the PRO-CTCAE questionnaire on tablet computers using AmbuFlex software at each treatment visit in the outpatient clinic. In total, 22 symptomatic toxicities (41 PRO-CTCAE items), corresponding to the symptomatic adverse-events profile associated with the regimens commonly used for prostate cancer treatment (Docetaxel, Cabazitaxel, Abiraterone, Alpharadin), were selected. Participants’ PRO-CTCAE responses were presented graphically to their treating oncologists via an AmbuFlex dashboard, for real-time use to enhance the patient-clinician dialogue that occurs during the consultation prior to each treatment cycle. Technical and clinical barriers and acceptability were evaluated through semi-structured interviews with both patients and oncologists. Patients receiving active treatment at the end of the study period completed an evaluation questionnaire. Results: Fifty-four out of sixty-three (86%) eligible patients were enrolled. The PRO-CTCAE questionnaire was completed a total of 168 times by 54 participants (median number per patient was 3, range 1–5). Eight surveys were missed, resulting in a compliance rate of 97%. At the end of the study period, 35 patients (65%) were still receiving active treatment and completed the evaluation questionnaire. Patients reported that their PRO-CTCAE responses served as a communication tool. Oncologists stated that the availability of the PRO-CTCAE self-reports during the consultation improved patient-clinician communication about side effects. Conclusion: Electronic capture of symptomatic toxicities using PRO-CTCAE and the submission of self-reports to clinicians prior to consultation were feasible among metastatic prostate cancer patients receiving chemotherapy in an outpatient setting, and this procedure was acceptable to both patients and clinicians. Continued research, including a cluster-randomized trial, will evaluate the effects of submitting patients’ PRO-CTCAE results to clinicians prior to consultation on the quality of side-effects management and resultant clinical outcomes.
Partitioned fluid-structure interaction simulation of maritime applications
Creators: name: Lund, Jorrid
Publisher: name: TUHH Universitätsbibliothek
Year: 2024
Subjects: subject: fluid-structure interaction
subject: partitioned coupling
subject: finite element method
subject: computational fluid dynamics
subject: maritime applications
classificationCode: 6
subject: Technology::621: Applied Physics::621.3: Electrical Engineering, Electronic Engineering
classificationCode: 6
subject: Technology::620: Engineering::620.1: Engineering Mechanics and Materials Science

description: In this work, the benefits of employing the partitioned approach in fluid-structure interaction simulations are demonstrated in four different examples: Simulations of a floating offshore wind turbine and a wave energy converter are used to analyze dynamic effects and improve the structural design. A multilayered submersible mixer validates the simulations by assessing local strains, thrust, and torque. Finally, an anisotropic ship propeller made of carbon-reinforced polymer is optimized with an evolutionary algorithm based on coupled simulations concerning efficiency, thrust, and cavitation.
description: In dieser Arbeit wird der Nutzen des partitionierten Ansatzes für die Fluid-Struktur-Interaktionssimulation von maritimen Anwendungsfällen an vier verschiedenen Beispielen demonstriert: Die Simulationen einer schwimmenden Offshore-Windenergieanlage und eines Wellenergiekonverters werden genutzt, um dynamische Effekte zu analysieren und das Strukturdesign zu verbessern. Ein mehrschichtig aufgebautes flexibles Tauchrührwerk dient der Validierung der Simulation anhand von lokalen Dehnungen, Schub und Drehmoment. Am Ende wird ein anisotroper Schiffspropeller aus kohlefaserverstärktem Kunststoff basierend auf gekoppelten Simulationen in Bezug auf Effizienz, Schub und Kavitation mit einem evolutionären Algorithmus optimiert.
The influence of peers on managerial honesty in participative budgeting: an integrated approach combining experiments and agent-based modeling
Creators: name: Plähn, Jannick
Publisher: name: TUHH Universitätsbibliothek
Year: 2024
Subjects: subject: Participative budgeting
subject: open internal reporting environment
subject: social norm
subject: managerial honesty
subject: peer sanctioning
subject: agent-based modeling
classificationCode: 6
subject: Technology::658: Marketing
classificationCode: 3
subject: Social Sciences::300: Social Sciences

description: Firms still rely on decentral managers participating in the budgeting process when preparing budgets. However, managers are incentivized to misreport their private information, decreasing the value of participative budgeting. This thesis focuses on how peers influence managerial honesty by establishing social norms. Specifically, I investigate how managerial honesty in open internal reporting environments is affected by peers when peer sanctioning is possible. Results of two experiments show that the possibility of peer sanctioning can increase honesty under certain conditions. The combination of experiments and agent-based modeling provides additional support for a social norm of honesty as the underlying mechanism.
description: Unternehmen verlassen sich in der Budgetierung nach wie vor auf die Informationen dezentraler Manager. Für Manager besteht jedoch ein Anreiz, ihre Informationen unwahr anzugeben. Diese Arbeit befasst sich mit der Frage, wie Kollegen über die Gestaltung von sozialen Normen die Ehrlichkeit von Managern beeinflussen. Konkret wird untersucht, wie die Ehrlichkeit von Managern durch informelle Sanktionen der Kollegen beeinflusst wird. Zwei Experimenten zeigen, dass die Möglichkeit der Sanktionierung durch Kollegen die Ehrlichkeit unter bestimmten Bedingungen erhöht. Die agentenbasierte Modellierung liefert Unterstützung für eine soziale Norm als zugrunde liegenden Mechanismus.
Second-line hormonal therapy for men with chemotherapy-naive, castration-resistant prostate cancer: American society of clinical oncology provisional clinical opinion
Creators: name: Nordquist, L.
name: Winquist, E.
name: Taplin, M.-E.
name: Oliver, T.K.
name: Basch, E.
name: Singer, E.A.
name: Carducci, M.A.
name: Andrew Loblaw, D.
name: Virgo, K.S.
name: Rumble, R.B.
Publisher: name: American Society of Clinical Oncology
Year: 2017

description: ASCO provisional clinical opinions (PCOs) offer direction to the ASCO membership after publication or presentation of potential practice-changing data. This PCO addresses second-line hormonal therapy for chemotherapy-näive men with castration-resistant prostate cancer (CRPC) who range from being asymptomatic with only biochemical evidence of CRPC to having documented metastases but minimal symptoms. Clinical Context The treatment goal for CRPC is palliation. Despite resistance to initial androgen deprivation therapy, most men respond to second-line hormonal therapies. However, guidelines have neither addressed second-line hormonal therapy for nonmetastatic CRPC nor provided specific guidance with regard to the chemotherapy-näive population. Recent Data Six phase III randomized controlled trials and expert consensus opinion inform this PCO. Provisional Clinical Opinion For men with CRPC, a castrate state should be maintained indefinitely. Second-line hormonal therapy (eg, antiandrogens, CYP17 inhibitors) may be considered in patients with nonmetastatic CRPC at high risk for metastatic disease (rapid prostate-specific antigen doubling time or velocity) but otherwise is not suggested. In patients with radiographic evidence of metastases and minimal symptoms, enzalutamide or abiraterone plus prednisone should be offered after discussion with patients about potential harms, benefits, costs, and patient preferences. Radium-223 and sipuleucel-T also are options. No evidence provides guidance about the optimal order of hormonal therapies for CRPC beyond second-line treatment. Prostate-specific antigen testing every 4 to 6 months is reasonable for men without metastases. Routine radiographic restaging generally is not suggested but can be considered for patients at risk for metastases or who exhibit symptoms or other evidence of progression. Additional information is available at www.asco.org/genitourinary-cancer-guidelines and www.asco.org/guidelineswiki.
On the Metric Temporal Logic for Continuous Stochastic Processes
Creators: name: Ikeda, Mitsumasa
name: Yamagata, Yoriyuki
name: Kihara, Takayuki
Publisher: name: arXiv
Year: 2023
Subjects: subject: Logic in Computer Science (cs.LO)
subject: Logic (math.LO)
subject: Probability (math.PR)
subject: FOS: Computer and information sciences
subject: FOS: Mathematics

description: In this paper, we prove measurability of event for which a general continuous-time stochastic process satisfies continuous-time Metric Temporal Logic (MTL) formula. Continuous-time MTL can define temporal constrains for physical system in natural way. Then there are several researches that deal with probability of continuous MTL semantics for stochastic processes. However, proving measurability for such events is by no means an obvious task, even though it is essential. The difficulty comes from the semantics of "until operator", which is defined by logical sum of uncountably many propositions. Given the difficulty involved in proving the measurability of such an event using classical measure-theoretic methods, we employ a theorem from stochastic analysis. This theorem is utilized to prove the measurability of hitting times for stochastic processes, and it stands as a profound result within the theory of capacity. Next, we provide an example that illustrates the failure of probability approximation when discretizing the continuous semantics of MTL formulas with respect to time. Additionally, we prove that the probability of the discretized semantics converges to that of the continuous semantics when we impose restrictions on diamond operators to prevent nesting.
Methods for Implementing and Reporting Patient-reported Outcome (PRO) Measures of Symptomatic Adverse Events in Cancer Clinical Trials
Creators: name: Basch, E.
name: Dueck, A.C.
name: Rogak, L.J.
Publisher: name: Excerpta Medica Inc.
Year: 2016

description: Purpose There is increasing interest to use patient-reported outcome (PRO) measures to evaluate symptomatic adverse events (AEs) in cancer treatment trials. However, there are currently no standard recommended approaches for integrating patient-reported AE measures into trials. Methods Approaches are identified from previous trials for selecting AEs for solicited patient reporting, administering patient-reported AE measures, and analyzing and reporting results. Findings Approaches for integrating patient-reported AE measures into cancer trials generally combine current standard methods for clinician-reported AEs and established best practices for using PRO measures. Specific AEs can be selected for a PRO questionnaire based on common and expected reactions in a given trial context, derived from literature review and qualitative/mixed-methods evaluations and should be the same set administered across all arms of a trial. A mechanism for collecting unsolicited patient-reported AEs will also ideally be included. Patients will preferably report at baseline and at the end of active treatment as well as on a frequent standardized schedule during active treatment, such as weekly from home, with a recall period corresponding to the frequency of reporting (eg, past 7 days). Less frequent reporting may be considered after an initial intensive monitoring period for trials of prolonged treatments and during long-term follow-up. Electronic PRO data collection is preferred. Backup data collection for missed PRO reports is advisable to boost response rates. Analysis can use a combination of approaches to AE and PRO data. If a high proportion of patients is experiencing baseline symptoms, systematic subtraction of these from on-study AEs should be considered to improve reporting of symptoms related to treatment. More granular longitudinal analyses of individual symptoms can also be useful. Implications Methods are evolving for integrating patient-reported symptomatic AEs into cancer trials. These methods are expected to further evolve as more data from trials become available.
Guideline to apply hedging to mitigate the risk of construction materials price escalation
Creators: name: Al-Zarrad, Mohammad Ammar
name: Moynihan, Gary P.
name: Vereen, Stephanie C.
Publisher: name: The University of British Columbia
Year: 2015

description: Accurately forecasting cost is vital to the success of any construction project. Cost estimation encompasses uncertainty, since construction projects are exposed to many forms and degrees of risk. Materials price volatility and shocks constitute one aspect. Most current approaches for material risk assessment are deterministic and do not take into consideration material price fluctuation. The application of hedging, to mitigate the risk of construction material price fluctuations, is proposed in this research. Although it is known that using hedging as a risk management tool adds value to a financial firm, limited knowledge has been established about using hedging for construction material price risk mitigation. Hedging has also been a practice applied in the airline industry for a long time, and substantive research has been completed in the field of airline fuel hedging. The objective of this research is to identify best practices in the area of airline fuel hedging to provide an outline for implementation in the construction industry, and to develop a step-by-step guideline to applying materials hedging in the construction industry. This is considered to be the first attempt to match construction material hedging with the airline fuel hedging application. The guideline presented herein helps construction companies to apply hedging to mitigate the risk of construction material price fluctuations. This guideline improves construction companies’ ability to submit a very competitive bid on a specific project.
Danish Translation and Linguistic Validation of the U.S. National Cancer Institute's Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE)
Creators: name: Pappot, H.
name: Bidstrup, P.E.
name: Mitchell, S.A.
name: Johansen, C.
name: Dalton, S.O.
name: Basch, E.
name: Nissen, A.
name: Bæksted, C.
Publisher: name: Elsevier Inc.
Year: 2016

description: Context The Common Terminology Criteria for Adverse Events (CTCAE) is the basis for standardized clinician-based grading and reporting of adverse events in cancer clinical trials. The U.S. National Cancer Institute has developed the Patient-Reported Outcomes version of the CTCAE (PRO-CTCAE) to incorporate patient self-reporting of symptomatic adverse events. Objectives The aim of the study was to translate and linguistically validate a Danish language version of PRO-CTCAE. Methods The U.S. English language PRO-CTCAE was translated into Danish using forward and backward procedures with reconciliation. The linguistic validity of the PRO-CTCAE Danish was examined in two successive rounds of semistructured cognitive interviews in a sample of 56 patients equally distributed by gender and cancer type (prostate, head and neck, lung, breast, gynecological, gastrointestinal, and hematological cancer), and who were currently undergoing cancer treatment. Results In the first round of linguistic validation (n = 42), the phrasing of five symptomatic toxicities was adjusted, and the refined phrasing was retested in a second round of interviews (n = 14). Agreement about phrasing that was both culturally acceptable and semantically comprehensible was achieved in the second round. Statements from participants describing the meaning of the PRO-CTCAE symptomatic toxicities support conceptual equivalence to the U.S. English language version. Conclusion Availability of the NCI PRO-CTCAE in languages beyond English will support international congruence in self-reporting of side effects of cancer treatment. A rigorous methodology was used to develop the Danish language version of PRO-CTCAE. Results provide preliminary support for the use of PRO-CTCAE in cancer clinical trials that include Danish speakers.
Efficient Algorithms for Finite $\mathbb{Z}$-Algebras
Creators: name: Kreuzer, Martin
name: Walsh, Florian
Publisher: name: arXiv
Year: 2023
Subjects: subject: Commutative Algebra (math.AC)
subject: Rings and Algebras (math.RA)
subject: FOS: Mathematics
subject: 13P99 (Primary) 68W39, 13P10, 68Q15 (Secondary)

description: For a finite $\mathbb{Z}$-algebra $R$, i.e., for a $\mathbb{Z}$-algebra which is a finitely generated $\mathbb{Z}$-module, we assume that $R$ is explicitly given by a system of $\mathbb{Z}$-module generators $G$, its relation module ${\rm Syz}(G)$, and the structure constants of the multiplication in $R$. In this setting we develop and analyze efficient algorithms for computing essential information about $R$. First we provide polynomial time algorithms for solving linear systems of equations over $R$ and for basic ideal-theoretic operations in $R$. Then we develop ZPP (zero-error probabilitic polynomial time) algorithms to compute the nilradical and the maximal ideals of 0-dimensional affine algebras $K[x_1,\dots,x_n]/I$ with $K=\mathbb{Q}$ or $K=\mathbb{F}_p$. The task of finding the associated primes of a finite $\mathbb{Z}$-algebra $R$ is reduced to these cases and solved in ZPPIF (ZPP plus one integer factorization). With the same complexity, we calculate the connected components of the set of minimal associated primes ${\rm minPrimes}(R)$ and then the primitive idempotents of $R$. Finally, we prove that knowing an explicit representation of $R$ is polynomial time equivalent to knowing a strong Gröbner basis of an ideal $I$ such that $R = \mathbb{Z}[x_1,\dots,x_n]/I$.
description: Published in journal of Groups, Complexity, Cryptology
Unlocking the Potential of Containers in Scientific Computing to Achieve Bitwise Reproducibility, Portability and Performance
Creators: name: Iaquinta, Jean
name: Fouilloux, Anne
Publisher: name: Zenodo
Year: 2024
Subjects: Containers
intra-node communications
reproducibility

description: This presentation was prepared for the Special Science Session of the NeIC2024 conference on "Containers for HPC"
description: The modern form of containers, as popularly known through platforms like Docker, Singularity (Apptainer), Podman or Charliecloud, to cite only a few, began to take shape over a decade ago. However, the fundamentals behind containerization and actual benefits of containers in scientific computing remain largely unclear to a vast majority of users. In fact, there is a significant gap between simplistic “Hello world” examples found online and real scientific applications. Also, rumors suggest that achieving satisfactory performances on supercomputers across multiple nodes is impossible.The aim of this paper is to explain how containers can leverage the potential of high-speed networks for inter-node communications with UCX on Fram and Betzy (from the Norwegian national e-infrastructure provider).It is also shown how to achieve near-native performance on LUMI (EuroHPC’s flagship) despite a “Slingshot-11” interconnect and proprietary library.Results obtained in the standard OSU Micro-Benchmarks tests for latency and bandwidth, and with a fully-fledged climate model, demonstrate that containerized applications work just as well as their bare-metal counterparts, are portable and provide bit-for-bit reproducibility on different platforms.Containers are therefore highly recommended to minimize deployment and porting issues i) for AaaS (Applications as a Service) coming with all the necessary software environment (rather than source code only); and ii) so that HPC users do not have to rely on anybody to install what they need and can be operational within minutes whilst still getting top performance.
Patient-reported outcomes in the evaluation of toxicity of anticancer treatments
Creators: name: Perrone, F.
name: Basch, E.
name: Bryce, J.
name: Di Maio, M.
Publisher: name: Nature Publishing Group
Year: 2016

description: Symptomatic toxicities associated with anticancer treatments, such as nausea and vomiting, are frequently underreported by clinicians, even when data are prospectively collected within clinical trials. Such underreporting can result in an underestimation of the absolute rate of toxicity, which is highly relevant information for patients and their physicians in clinical practice, and for regulatory authorities. Systematic collection of patient-reported outcomes (PROs) has been demonstrated to be a valid, reliable, feasible and precise approach to tabulating symptomatic toxicities and enables symptoms that are missed by clinicians to be detected. In this Perspectives, the barriers and challenges that should be addressed when considering broad integration of PRO toxicity monitoring in oncology clinical trials are discussed, including challenges related to data collection logistics, analytical approaches, and resource utilization. Instruments conceived to enable description of treatment-related adverse effects, from the patient perspective, bring the potential to improve risk-versus-benefit analyses in clinical research, and to provide patients with accurate information, on the basis of previous experiences of their peers.
Degrees in random $m$-ary hooking networks
Creators: name: Bhutani, Kiran R.
name: Kalpathy, Ravi
name: Mahmoud, Hosam
Publisher: name: arXiv
Year: 2023
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 05C82, 90B15 (Primary) 60C05, 60F05 (Secondary)

description: The theme in this paper is a composition of random graphs and Pólya urns. The random graphs are generated through a small structure called the seed. Via Pólya urns, we study the asymptotic degree structure in a random $m$-ary hooking network and identify strong laws. We further upgrade the result to second-order asymptotics in the form of multivariate Gaussian limit laws. We give a few concrete examples and explore some properties with a full representation of the Gaussian limit in each case. The asymptotic covariance matrix associated with the Pólya urn is obtained by a new method that originated in this paper and is reported in [25].
description: 21 pages, 5 figures
First Passage Times for Continuous Quantum Measurement Currents
Creators: name: Kewming, Michael J.
name: Kiely, Anthony
name: Campbell, Steve
name: Landi, Gabriel T.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The First Passage Time (FPT) is the time taken for a stochastic process to reach a desired threshold. In this letter we address the FPT of the stochastic measurement current in the case of continuously measured quantum systems. Our approach is based on a charge-resolved master equation, which is related to the Full-Counting statistics of charge detection. In the quantum jump unravelling this takes the form of a coupled system of master equations, while for quantum diffusion it becomes a type of quantum Fokker-Planck equation. In both cases, we show that the FPT can be obtained by introducing absorbing boundary conditions, making their computation extremely efficient {and analytically tractable}. The versatility of our framework is demonstrated with two relevant examples. First, we show how our method can be used to study the tightness of recently proposed kinetic uncertainty relations (KURs) for quantum jumps, which place bounds on the signal-to-noise ratio of the FPT. Second, we study the usage of qubits as threshold detectors for Rabi pulses, and show how our method can be employed to maximize the detection probability while, at the same time, minimize the occurrence of false positives.
description: 8 pages, 2 figures
Repeated measures analysis of patient-reported outcomes in prostate cancer after abiraterone acetate
Creators: name: Li, S.
name: Li, T.
name: Todd, M.B.
name: Kheoh, T.
name: Cella, D.
name: Basch, E.
Publisher: name: Frontline Medical Communications
Year: 2016

description: Background: Metastatic castration-resistant prostate cancer (mCRPC) is typically associated with declining health-related quality of life (HR-QoL). Objective: To assess patient experience with abiraterone acetate (hereafter abiraterone) plus prednisone longitudinally. Methods: COU-AA-302 was a phase 3, multinational, randomized, double-blind study that enrolled asymptomatic or mildly symptomatic, chemotherapy-naïve patients with mCRPC. Patients were randomized to 1 g abiraterone daily plus 5 mg prednisone BID (n = 546) or placebo plus prednisone (n = 542) in continuous 28-day cycles. Patient-reported outcomes (PROs) were collected using the Functional Assessment of Cancer Therapy-Prostate (FACT-P) questionnaire, consisting of 4 well-being subscales (physical, social/family, emotional, functional) and a prostate cancer-specific subscale (PCS). The trial outcome index (TOI) is a composite of the physical well-being, functional well-being, and PCS scores. Least squares mean change from baseline at each cycle up to 1 year (cycle13) was compared between treatment arms using a mixed-effects model for repeated measures, which assumed that data were "missing at random." A pattern-mixture model (PMM) with multiple imputation was performed to address the assumption that data were "missing not at random." Results: Significant differences favoring abiraterone-prednisone were observed for FACT-P total, TOI, and PCS scores, and for all well-being subscales except social/family well-being over the first year of treatment. These results were supported by the PMM with multiple imputation. Limitations: Attrition after 1 year limited our ability to analyze the PRO data beyond that time point. Conclusions: Abiraterone-prednisone confers sustained HR-QoL benefits over the course of treatment.
Near-extremal Kerr-like ECO in the Kerr/CFT Correspondence in Higher Spin Perturbations
Creators: name: Djogama, M. Zhahir
name: Sakti, Muhammad F. A. R.
name: Zen, Freddy P.
name: Satriawan, Mirza
Publisher: name: arXiv
Year: 2023
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The Kerr/CFT correspondence has been established to explore the quantum theory of gravity in the near-horizon geometry of a extreme Kerr black holes. The quantum gravitational corrections on the near-horizon region may manifest in form of a partially reflective membrane that replace the horizon. In such modification, the black holes now can be seen as a horizonless exotic compact object (ECO). In this paper, we consider the properties of Kerr-like ECOs in near-extremal condition using Kerr/CFT correspondence. We study the quasinormal modes and absorption cross-section in that background and compare these by using CFT dual computation. The corresponding dual CFT one needs to incorporate finite size/finite $N$ effects in the dual CFT terminology. We also extend the dual CFT analysis for higher spin perturbations such as photon and graviton. We find consistency between properties of the ECOs from gravity sides and from CFT sides. The quasinormal mode spectrum is in line with non-extreme case, where the differences are in the length of the circle, on which the dual CFT lives, and phase shift of the incoming perturbation. The absorption cross-section has oscillatory feature that start to disappear near extremal limit. The particle spin determines the phase shift and conformal weight. We also obtain that the echo time-delay depends on the position of the membrane and extremality of the ECOs.
description: 16 pages, 7 figures, for submission to journal
Better infrastructure procurement for public private partnerships : an Australian perspective
Creators: name: Regan, M.
name: Smith, J.
name: Love, P. E. D.
Publisher: name: The University of British Columbia
Year: 2015

description: Public private partnerships (PPPs) are a method for the delivery of social and economic infrastructure services in over 80 countries worldwide. PPPs are a contractual arrangement between public and private entities through which the skills, assets and/or financial resources of both sectors are allocated in such a manner that provides optimal service delivery and good value to society. Central to the operation of public private partnerships is the systematic evaluation of the procurement options available to government, an output specification to encourage private design, risk transfer, construction and operational innovation, the detailed analysis of projects over their operational lifecycle, a rigorous and competitive bid process, and the selection of proposals that deliver value for money. Unlike traditional procurement, which is predominantly based on lowest cost to government, value for money (VFM) is a measure that takes into account both the quantitative and qualitative outcomes over the term of a contract. This paper is based on a larger study for the Asia Development Bank (ADB) which contained an international survey prepared by the authors. The ADB report reviewed PPP policy and using six case studies as a basis for comparison. Each study considered experience of policy and institutional frameworks, value for money evaluations and infrastructure projects delivered. The Australian case study is included in this paper as an example of good procurement practice.
A note on removable edges in near-bricks
Creators: name: Wu, Deyu
name: Zhang, Yipei
name: Wang, Xiumei
Publisher: name: arXiv
Year: 2023
Subjects: subject: Combinatorics (math.CO)
subject: FOS: Mathematics

description: An edge $e$ of a matching covered graph $G$ is removable if $G-e$ is also matching covered. Carvalho, Lucchesi, and Murty showed that every brick $G$ different from $K_4$ and $\overline{C_6}$ has at least $Δ-2$ removable edges, where $Δ$ is the maximum degree of $G$. In this paper, we generalize the result to irreducible near-bricks, where a graph is irreducible if it contains no single ear of length three or more.
Supplementary document for Custom terahertz waveforms using complementary organic nonlinear optical crystals - 6099948.pdf
Creators: name: Rader, Claire
name: Nielson, Megan
name: Knighton, Brittany
name: Zaccardi, Zachary
name: Michaelis, David
name: Johnson, Jeremy
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Extra description of EO-sampling, phase matching, spectral modeling, and circular polarization.
LiHoF4 as a spin-half non-standard quantum Ising system
Creators: name: Dollberg, Tomer
name: Schechter, Moshe
Publisher: name: arXiv
Year: 2023
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: $\mathrm{LiHoF_{4}}$ is a magnetic material known for its Ising-type anisotropy, making it a model system for studying quantum magnetism. However, the theoretical description of $\mathrm{LiHoF_{4}}$ using the quantum Ising model has shown discrepancies in its phase diagram, particularly in the regime dominated by thermal fluctuations. In this study, we investigate the role of off-diagonal dipolar terms in $\mathrm{LiHoF_{4}}$, previously neglected, in determining its properties. We analytically derive the low-energy effective Hamiltonian of $\mathrm{LiHoF_{4}}$, including the off-diagonal dipolar terms perturbatively, both in the absence and presence of a transverse field. Our results encompass the full $B_{x}-T$ phase diagram, confirming the significance of the off-diagonal dipolar terms in reducing the zero-field critical temperature and determining the critical temperature's dependence on the transverse field. We also highlight the sensitivity of this mechanism to the crystal structure by comparing our calculations with the $\mathrm{Fe_{8}}$ system.
description: v3: 31 pages, 9 figures; new appendices D-F and other changes
Antiemetics: American Society of Clinical Oncology focused guideline update
Creators: name: Kris, M.G.
name: Jordan, K.
name: Lyman, G.H.
name: Basch, E.
name: Hesketh, P.J.
name: Chesney, M.
name: Somerfield, M.R.
name: Clark-Snow, R.A.
name: Danso, M.A.
name: Bohlke, K.
Publisher: name: American Society of Clinical Oncology
Year: 2016

description: Purpose: To update a key recommendation of the American Society of Clinical Oncology antiemetic guideline. This update addresses the use of the oral combination of netupitant (a neurokinin 1 [NK1] receptor antagonist) and palonosetron (a 5-hydroxytryptamine-3 [5-HT3] receptor antagonist) for the prevention of acute and delayed nausea and vomiting in patients receiving chemotherapy. Methods: An update committee conducted a targeted systematic literature review and identified two phase III clinical trials and a randomized phase II dose-ranging study. Results: In one phase III trial, the oral combination of netupitant and palonosetron was associated with higher complete response rates (no emesis and no rescue medications) compared with palonosetron alone in patients treated with anthracycline plus cyclophosphamide chemotherapy (74% v 67% overall; P = .001). In another phase III trial, the oral combination of netupitant and palonosetron was safe and effective across multiple cycles of moderately or highly emetogenic chemotherapies. In the phase II dose-ranging study, each dose of netupitant (coadministered with palonosetron 0.50 mg) produced higher complete response rates than palonosetron alone among patients receiving cisplatin-based chemotherapy. The highest dose of netupitant (ie, 300 mg) was most effective. Recommendations: All patients who receive highly emetogenic chemotherapy regimens (including anthracycline plus cyclophosphamide) should be offered a three-drug combination of an NK1 receptor antagonist, a 5-HT3 receptor antagonist, and dexamethasone. The oral combination of netupitant and palonosetron plus dexamethasone is an additional treatment option in this setting. The remaining recommendations from the 2011 ASCO guideline are unchanged pending a full update. Additional information is available at www.asco.org/guidelines/antiemetics and www.asco.org/guidelineswiki.
Abiraterone in metastatic prostate cancer without previous chemotherapy
Creators: name: Ng, S.
name: Van Poppel, H.
name: Winquist, E.
name: Fizazi, K.
name: Small, E.J.
name: Saad, F.
name: Yu, E.Y.
name: Mainwaring, P.
name: Mukherjee, S.D.
name: De Souza, P.
name: Carles, J.
name: Suttmann, H.
name: Molina, A.
name: Basch, E.
name: Taplin, M.-E.
name: Smith, M.R.
name: Logothetis, C.J.
name: Griffin, T.
name: Scher, H.I.
name: Ryan, C.J.
name: Piulats, J.M.
name: Rathkopf, D.E.
name: Flaig, T.W.
name: Efstathiou, E.
name: Mulders, P.F.A.
name: Pantuck, A.
name: De Bono, J.S.
name: Higano, C.S.
name: Schrijvers, D.
name: Gerritsen, W.R.
name: Park, Y.
name: Kheoh, T.
name: George, D.J.
Publisher: name: Massachussetts Medical Society
Year: 2013

description: Background: Abiraterone acetate, an androgen biosynthesis inhibitor, improves overall survival in patients with metastatic castration-resistant prostate cancer after chemotherapy. We evaluated this agent in patients who had not received previous chemotherapy. Methods: In this double-blind study, we randomly assigned 1088 patients to receive abiraterone acetate (1000 mg) plus prednisone (5 mg twice daily) or placebo plus prednisone. The coprimary end points were radiographic progression-free survival and overall survival. Results: The study was unblinded after a planned interim analysis that was performed after 43% of the expected deaths had occurred. The median radiographic progressionfree survival was 16.5 months with abiraterone - prednisone and 8.3 months with prednisone alone (hazard ratio for abiraterone - prednisone vs. prednisone alone, 0.53; 95% confidence interval [CI], 0.45 to 0.62; P<0.001). Over a median follow-up period of 22.2 months, overall survival was improved with abiraterone - prednisone (median not reached, vs. 27.2 months for prednisone alone; hazard ratio, 0.75; 95% CI, 0.61 to 0.93; P = 0.01) but did not cross the efficacy boundary. Abiraterone - prednisone showed superiority over prednisone alone with respect to time to initiation of cytotoxic chemotherapy, opiate use for cancer-related pain, prostate-specific antigen progression, and decline in performance status. Grade 3 or 4 mineralocorticoid-related adverse events and abnormalities on liver-function testing were more common with abiraterone-prednisone. Conclusions: Abiraterone improved radiographic progression-free survival, showed a trend toward improved overall survival, and significantly delayed clinical decline and initiation of chemotherapy in patients with metastatic castration-resistant prostate cancer.
How do you know if you are any good? A surgeon performance feedback system for the outcomes of radical prostatectomy
Creators: name: Sculli, F.
name: Basch, E.
name: Vickers, A.J.
name: Laudone, V.
name: Eastham, J.
name: Sjoberg, D.
name: Scardino, P.T.
name: Touijer, K.
name: Shouery, M.
Publisher: name: Elsevier B.V.
Year: 2012

description: Surgery remains a mainstay of initial treatment for prostate cancer, with an estimated 85,000 operations per year in the US. Radical prostatectomy is associated with important risks of erectile dysfunction, urinary incontinence and, naturally, cancer recurrence. Given the possible consequences, it would be reassuring were it known that urologic surgeons offer uniformly high-quality care. Unfortunately, the data suggest that this is far from the case. There is copious evidence that surgeons with greater case volume or total lifetime experience have better outcomes. For example, low volume surgeons have complication rates 6 to 8% greater than their higher volume counterparts; in studies on the learning curve, the risk of recurrence is about 7% higher for a typical patient treated by an inexperienced surgeon than if treated by a more experienced surgeon There are also data that differences in outcome go over and above characteristics such as volume or experience, with large variations between surgeons even within volume categories, with one study reporting a five-fold variation in potency rates between surgeons at a single institution.
On countable isotypic structures
Creators: name: Gvozdevsky, Pavel
Publisher: name: arXiv
Year: 2023
Subjects: subject: Logic (math.LO)
subject: FOS: Mathematics
subject: 03C07(Primary) 03C60, 03C64 and 12L12(Secondary)

description: We obtain several results concerning the concept of isotypic structures. Namely we prove that any field of finite transcendence degree over a prime subfield is defined by types; then we construct isotypic but not isomorphic structures with countable underlying sets: totally ordered sets, fields, and groups. This answers an old question by B. Plotkin for groups.
description: 6 pages, Published in journal of Groups, Complexity, Cryptology