cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
SpeX Spectroscopy of Unresolved Very Low Mass Binaries. II. Identification of Fourteen Candidate Binaries with Late-M/Early-L and T Dwarf Components
Creators: name: Gagliuffi, Daniella C. Bardalez
name: Burgasser, Adam J.
name: Gelino, Christopher R.
name: Looper, Dagny L.
name: Nicholls, Christine P.
name: Schmidt, Sarah J.
name: Cruz, Kelle
name: West, Andrew A.
name: Gizis, John E.
name: Metchev, Stanimir
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Multiplicity is a key statistic for understanding the formation of very low mass (VLM) stars and brown dwarfs. Currently, the separation distribution of VLM binaries remains poorly constrained at small separations ($\leq$ 1 AU), leading to uncertainty in the overall binary fraction. We approach this problem by searching for late-M/early-L plus T dwarf spectral binaries whose combined light spectra exhibit distinct peculiarities, allowing for separation-independent identification. We define a set of spectral indices designed to identify these systems, and use a spectral template fitting method to confirm and characterize spectral binary (SB) candidates from a library of 815 spectra from the SpeX Prism Spectral Libraries. We present eleven new binary candidates, confirm three previously reported candidates and rule out two previously identified candidates, all with primary and secondary spectral types between M7-L7 and T1-T8, respectively. We find that subdwarfs and blue L dwarfs are the primary contaminants in our sample and propose a method for segregating these sources. If confirmed by follow-up observations, these systems may add to the growing list of tight separation binaries, whose orbital properties may yield further insight into brown dwarf formation scenarios.
description: 49 pages, 9 figures. v3 includes sigma values for table 4, and corrected table 3 and figure 2
Recent Advances in Intravesical Drug/Gene Delivery
Creators: name: Wu, Pao-Chu
name: Tyagi, Pradeep
name: Yoshimura, Naoki
name: Huang, Leaf
name: Chancellor, Michael
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2006

description: Targeting of the drugs administered systemically relies on the higher affinity of ligands for specific receptors to obtain selectivity in drug response. However, achieving the same goal inside the bladder is much easier with an intelligent pharmaceutical approach that restricts drug effects by exploiting the pelvic anatomical architecture of the human body. This regional therapy involves placement of drugs directly into the bladder through a urethral catheter. It is obvious that drug administration by this route holds advantage in chemotherapy of superficial bladder cancer and it has now become the most widely used treatment modality for this ailment. In recent years, the intravesical route has also been exploited either as an adjunct to an oral regimen or as a second-line treatment for neurogenic bladder 1, 2. Instillation of DNA via this route using different vectors has been able to restrict the transgene expression in organs other than bladder. The present review article will discuss the shortcomings of the current options available for intravesical drug delivery (IDD) and lay a perspective for future developments in this field.
Aquatic macrophytes, macroinvertebrate associations and water levels in a lowland Tasmanian river
Creators: name: Humphries, Paul
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

Aquatic macrophytes are a common habitat for macroinvertebrates and may occupy depth zones in the littoral region of lowland rivers. Studies have indicated that different species of macrophyte typically support different assemblages, abundances and numbers of species of macroinvertebrates. This has often been attributed to differences in the dissectedness of stems and leaves of the macrophytes, resulting in differences in the surface area and/or the number of microhabitats available to invertebrates. I set out to measure the abundance and taxonomic richness and to describe the macroinvertebrate assemblages associated with three species of aquatic macrophyte in a pool in the Macquarie River, Tasmania and to examine responses of these variables to changes in water levels over summer. The macrophyte species sampled wereMyriophyllum simulans/variifolium, Triglochin procera} and Eleocharis sphacelata, each one differing in the dissectedness of its stems and leaves and its location in the littoral zone. Whereas the greatest abundance of macroinvertebrates was found associated in all months (i.e. at all water levels) with the structurally complex and shallowest macrophyte species, Myriophyllum, the number of taxa associated with this species was in several cases lower than for the structurally simpler and deeper water Triglochin and Eleocharis. While water depth and total plant biomass of samples were often correlated with invertebrate abundance and richness, these relationships were different for each macrophyte species. Of the nine most common invertebrate taxa collected from all samples, the abundances of more than half showed consistent differences among macrophyte species across months, two showed differences among macrophytes, but with an interaction with month and two showed no differences among macrophytes. There were major differences in the invertebrate assemblages associated with each macrophyte species in any one month, however, there was also a large turnover of taxa associated with the species of macrophytes from one month to the next. Changes in water level and concomitant changes in environmental variables are suggested as factors influencing the invertebrate fauna in the littoral zone of the pool of the Macquarie River. It is thus important for river managers to be aware that species of macroinvertebrates are not evenly distributed across species of macrophyte and that water levels and their influence on macrophytes as invertebrate habitat may play an integral part in determining the abundance, richness and assemblage of invertebrates in rivers.
Absolute Properties of the Oscillating Eclipsing Algol X Trianguli
Creators: name: Lee, Jae Woo
name: Hong, Kyeongsoo
name: Park, Jang-Ho
name: Wolf, Marek
name: Kim, Dong-Jin
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We report results from the TESS photometric data and new high-resolution spectra of the Algol system X Tri showing short-period pulsations. From the echelle spectra, the radial velocities of the eclipsing pair were measured, and the rotational rate and effective temperature of the primary star were obtained to be $v_1$$\sin$$i=84\pm6$ km s$^{-1}$ and $T_{\rm eff,1}=7900 \pm 110$ K, respectively. The synthetic modeling of these observations implies that X Tri is in synchronous rotation and is physically linked to a visual companion TIC 28391715 at a separation of about 6.5 arcsec. The absolute parameters of our target star were accurately and directly determined to be $M_1 = 2.137 \pm 0.018$ $M_\odot$, $M_2 = 1.101 \pm 0.010$ $M_\odot$, $R_1 = 1.664 \pm 0.010$ $R_\odot$, $R_2 = 1.972 \pm 0.010$ $R_\odot$, $L_1 = 9.67 \pm 0.55$ $L_\odot$, and $L_2 = 2.16 \pm 0.09$ $L_\odot$. The phase-binned mean light curve was used to remove the binary effect from the observed TESS data. Multifrequency analysis of the residuals revealed 16 significant frequencies, of which the high-frequency signals between 37 day$^{-1}$ and 48 day$^{-1}$ can be considered probable pulsation modes. Their oscillation periods of 0.021$-$0.027 days and pulsation constants of 0.014$-$0.018 days are typical values of $δ$ Sct variables. The overall results demonstrate that X Tri is an oEA star system, consisting of a $δ$ Sct primary and its lobe-filling companion in the semi-detached configuration.
description: 27 pages, including 8 figures and 6 tables, accepted for publication in AJ
Induction of Cytotoxic T-Lymphocytes and Antitumor Activity by a Liposomal Lipopeptide Vaccine
Creators: name: Huang, Leaf
name: Chen, Weihsu
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: We have previously described a simple yet effective liposome-based therapeutic vaccine, DOTAP/E7, which contains only two molecules, the cationic lipid DOTAP and a peptide antigen derived from the E7 oncoprotein of human papillomavirus (HPV) type 16. In the current report, we have improved the vaccine formulation by incorporation of E7-lipopeptide instead of the water-soluble native E7 peptide into the DOTAP liposome. The lipopeptide consists of an N-terminal α- or ∊-palmitoyl lysine connected to the E7 peptide via a dipeptide Ser-Ser linker. The DOTAP/E7-lipopeptide vaccine exhibited an enhanced functional antigen-specific CD8+ T lymphocyte response in vivo compared to the previous DOTAP/E7 formulation. More importantly, the cytotoxic T cells induced by the DOTAP/E7-lipopeptide vaccine could efficiently eliminate an existing HPV positive TC-1 tumor. The antitumor activity of lipopeptide formulated in DOTAP liposome was more than twice as potent as that of native E7, likely owing to the increased peptide entrapment efficiency in the liposomal complex. Our results also showed that it is essential to have the dipeptide spacer sequence between E7 peptide and the attached fatty acid to achieve a full immune response. Overall, the improved DOTAP/E7-lipopeptide vaccine described herein showed a significantly enhanced therapeutic effect for the treatment of a cervical cancer model.
Recent Beam-Beam Effects at VEPP-2000 and VEPP-4M
Creators: name: Shwartz, Dmitry
name: Berkaev, Dmitry
name: Koop, Ivan
name: Levichev, Evgeny
name: Perevedentsev, Evgeny
name: Rogovsky, Yury
name: Romanov, Alexander
name: Shatilov, Dmitry
name: Shatunov, Petr
name: Shatunov, Yuri
Publisher: name: arXiv
Year: 2014
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: Budker INP hosts two e+e- colliders, VEPP-4M operating in the beam energy range of 1-5.5 GeV and the low-energy machine VEPP-2000, collecting data at 160-1000 MeV per beam. The latter uses a novel concept of round colliding beams. The paper presents an overview of observed beam-beam effects and obtained luminosities.
description: Presented at the ICFA Mini-Workshop on Beam-Beam in Hadron Colliders, CERN, Geneva, Switzerland, 18-22 March 2013
Commonalities in clonal selection during normal tissue and cancer development
Creators: name: ABADI, ABBAS SALAVATY HOSEIN
Publisher: name: Monash University
Year: 2023
Subjects: Cancer cell biology
Cell development, proliferation and death
Systems biology
Bioinformatics and computational biology not elsewhere classified
Bioinformatic methods development

description: Clonal selection and drift (i.e. proliferation and dominance of some cell clones and extinction of others, respectively) are critical phenomena during development. To evaluate the commonalities of this phenomena during normal tissue and cancer development we recruited computational techniques to analyze both normal and cancer tissue data. Also, several models, algorithms, and tools were developed to solve different problems we faced throughout the project. The comparative analyses revealed that while there are major differences in the drivers of selection in normal and cancer tissues, some key genes are common across different tissues and even between normal and cancerous ones.
Exhausting curve complexes by finite rigid sets
Creators: name: Aramayona, Javier
name: Leininger, Christopher J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics

description: Let $S$ be a connected orientable surface of finite topological type. We prove that there is an exhaustion of the curve complex $\mathcal{C}(S)$ by a sequence of finite rigid sets.
description: 22 pages, 16 figures
Steady-State Magnetohydrodynamic Flow Around an Unmagnetized Conducting Sphere
Creators: name: Romanelli, Norberto
name: Gomez, Daniel
name: Bertucci, Cesar
name: Delva, Magda
Publisher: name: arXiv
Year: 2014
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The non-collisional interaction between conducting obstacles and magnetized plasma winds can be found in different scenarios, from the interaction occurring between regions inside galaxy clusters to the interaction between the solar wind and Mars, Venus, active comets or even the interaction between Titan and the Saturnian's magnetospheric flow. These objects generate, through several current systems, perturbations in the streaming magnetic field leading to its draping around the obstacle's effective conducting surface. Recent observational results suggest that several properties associated with the magnetic field draping, such as the location of the polarity reversal layer of the induced magnetotail, are affected by variations in the conditions of the streaming magnetic field. To improve our understanding of these phenomena, we perform a characterization of several magnetic field draping signatures by analytically solving an ideal problem in which a perfectly conducting magnetized plasma (with frozen-in magnetic field conditions) flows around a spherical body for various orientations of the streaming magnetic field. In particular, we compute the shift of the inverse polarity reversal layer as the orientation of the background magnetic field is changed.
description: Preprint submitted to Astrophysical Journal
title: Ouverture
Creators: name: Nancy , Jean-Luc
Publisher: name: Roma Tre-Press
Year: 2011

description: Nell'articolo è rivendicato con forza e determinazione l'assunto che «ogni filosofia ha a che fare con l'apertura e l'agire», si dà immediatamente come praxis e come ethos, si tratta di «una postura del pensiero» non di una teoria che solo in un secondo momento si determina anche come filosofia dell'agire. Pensare è un atto, un'azione esplicita che accade tra-noi, esposti al mondo, gli uni e gli altri in quello spazio libero, quel "terreno vago", indeciso, che sta a noi destinare a qualcosa.

description: B@belonline vol. 10/11 Pensare con Jean-Luc Nancy
Husimi distribution and phase-space analysis of a vibron-model quantum phase transition
Creators: name: Calixto, M.
name: del Real, R.
name: Romera, E.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: The Husimi distribution is proposed for a phase space analysis of quantum phase transitions in the two-dimensional $U(3)$ vibron model for $N$-size molecules. We show that the inverse participation ratio and Wehrl's entropy of the Husimi distribution give sharp signatures of the quantum (shape) phase transition from linear to bent. Numerical results are complemented with a variational approach using parity-symmetry-adapted $U(3)$ coherent states, which reach the minimum Wehrl entropy $\frac{N(3+2N)}{(N+1)(N+2)}$, in the rigidly linear phase, according to a generalized Wehrl-Lieb conjecture. We also propose a characterization of the vibron-model quantum phase transition by means of the zeros of the Husimi distribution.
description: 8 pages, 8 figures
Microlensing of the broad emission line region in the lensed quasar J1004+4112
Creators: name: Hutsemékers, Damien
name: Sluse, Dominique
name: Savić, Đorđe
name: Richards, Gordon T.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: J1004+4112 is a lensed quasar for which the first broad emission line profile deformations due to microlensing were identified. Detailed interpretations of these features have nevertheless remained controversial. Based on 15 spectra obtained from 2003 to 2018, we revisit the microlensing effect that distorts the CIV broad emission line profile. We show that the microlensing-induced line profile distortions in image A, although variable, are remarkably similar over a period of 15 years. They are characterized by a strong magnification of the blue part of the line profile, a strong demagnification of the red part of the line profile, and a small-to-negligible demagnification of the line core. We used the microlensing effect to constrain the broad emission-line region (BLR) size, geometry, and kinematics. For this purpose, we modeled the deformation of the emission lines considering three simple, representative BLR models: a Keplerian disk, an equatorial wind, and a biconical polar wind, with various inclinations with respect to the line of sight. We find that the observed magnification profile of the CIV emission line can be reproduced with the simple BLR models we considered, without the need for more complex BLR features. The magnification appears dominated by the position of the BLR with respect to the caustic network -- and not by the velocity-dependent size of the BLR. The favored models for the CIV BLR are either the Keplerian disk or the equatorial wind, depending on the orientation of the BLR axis with respect to the caustic network. We also find that the polar wind model can be discarded. We measured the CIV BLR half-light radius as $r_{1/2} = 2.8^{+2.0}_{-1.7}$ light-days. This value is smaller than the BLR radius expected from the radius-luminosity relation derived from reverberation mapping, but it is still in reasonable agreement given the large uncertainties.
description: Accepted for publication in Astronomy & Astrophysics
Predicting interface structures: From SrTiO$_3$ to graphene
Creators: name: Schusteritsch, Georg
name: Pickard, Chris J.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We present here a fully first-principles method for predicting the atomic structure of interfaces. Our method is based on the {\it ab initio} random structure searching (AIRSS) approach, applied here to treat two dimensional defects. The method relies on repeatedly generating random structures in the vicinity of the interface and relaxing them within the framework of density functional theory (DFT). The method is simple, requiring only a small set of parameters that can be easily connected to the chemistry of the system of interest, and efficient, ideally adapted to high-throughput first-principles calculations on modern parallel architectures. Being first-principles, our method is transferable, an important requirement for a generic computational method for the determination of the structure of interfaces. Results for two structurally and chemically very different interfaces are presented here, grain boundaries in graphene and grain boundaries in strontium titanate (SrTiO$_3$). We successfully find a previously unknown low energy grain boundary structure for the graphene system, as well as recover the previously known higher energy structures. For the SrTiO$_3$ system we study both stoichiometric and non-stoichiometric compositions near the grain boundary and find previously unknown low energy structures for all stoichiometries. We predict that these low energy structures have long-range distortions to the ground state crystal structure emanating into the bulk from the interface.
description: 17 pages, 5 figures; corrected typos and corrected references
Biological Barriers to Therapy with Antisense and siRNA Oligonucleotides
Creators: name: Bauman, J.
name: Juliano, R.
name: Ming, X.
name: Kang, H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Attaining the full therapeutic utility of antisense and siRNA oligonucleotides will require understanding of the biological barriers that stand between initial administration of these drugs and their final actions within cells. This article examines some of the key barriers that affect the biodistribution of oligonucleotides both in molecular form and when they are associated with nanocarriers. An understanding of the biological processes underlying these barriers will aid in the design of more effective delivery systems.
Energy Consumption, Transportation, and Sustainability from the UK to the US
Creators: name: Anastasakos, Evgenia
Publisher: name: Unknown
Year: 2024
Subjects: subject: public transportation
subject: domestic energy
subject: 1970s miner strikes
subject: energy efficiency
subject: minimalism
subject: food consumption
subject: climate awareness
subject: renewable energy

description: Evgenia Anastasakos interviews mother Julia Harris, born in London and later living in Surrey and southwest England, reflecting on her evolving experiences with energy. In her early years, electricity use was minimal, limited mainly to overhead lights, with many battery-powered appliances like radios. Julia recalls the transition from diesel to electric trains and the impact of the 1970s coal miners' strikes, which led to a three-day energy week, pushing her to spend more time outdoors. She notes significant differences between the UK and the US, particularly regarding transportation, vehicle efficiency, and public transit systems. She also discusses changes in domestic energy use, from hand-washed laundry to more modern appliances, and the shift in food production towards processed goods, though her family maintained a preference for fresh, home-cooked meals. Julia highlights a growing environmental awareness in the UK, contrasting it with the gradual waste reduction efforts she observes in the US.
Maximal area integral problem for certain class of univalent analytic functions
Creators: name: Ponnusamy, Saminathan
name: Sahoo, Swadesh Kumar
name: Sharma, Navneet Lal
Publisher: name: arXiv
Year: 2014
Subjects: subject: Complex Variables (math.CV)
subject: FOS: Mathematics
subject: 30C45, 30C70, 30H10, 33C05

description: One of the classical problems concerns the class of analytic functions $f$ on the open unit disk $|z|<1$ which have finite Dirichlet integral $Δ(1,f)$, where $$Δ(r,f)=\iint_{|z|
description: 16 pages, 8 figures, 3 tables
Knocking Down Breast Cancer Resistance Protein (Bcrp) by Adenoviral Vector-Mediated RNA Interference (RNAi) in Sandwich-Cultured Rat Hepatocytes: A Novel Tool To Assess the Contribution of Bcrp to Drug Biliary Excretion
Creators: name: Yue, Wei
name: Brouwer, Kim L. R.
name: Abe, Koji
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: BCRP transports numerous drugs/derived metabolites and toxins, and exhibits overlapping substrate specificity with P-glycoprotein (P-gp) and multidrug resistance-associated protein 2 (MRP2). Assessing the contribution of BCRP to drug/metabolite biliary excretion in the intact hepatocytes remains a challenge. Current studies were designed to develop a novel in vitro tool to specifically assess the contribution of Bcrp to drug biliary excretion. Adenoviral vectors expressing short hairpin (sh) RNA targeting Bcrp (Ad-si01Bcrp) or a non-target control (Ad-siNT) were packaged and infected into sandwich-cultured rat hepatocytes (SCRH). Protein levels were detected by immunoblot. Biliary excretion index (BEI) and in vitro biliary clearance (Clbiliary) of nitrofurantoin (BCRP substrate) and digoxin (P-gp substrate) were compared among non-infected, Ad-siNT- and Ad-si01Bcrp-infected cells in SCRH. shRNA targeting Bcrp efficiently knocked down Bcrp in SCRH, while levels of other transport proteins (P-gp, Mrp2, Bsep, Mrp4 and Oatp1a1) were unaffected. In SCRH exhibiting Bcrp knockdown, cellular accumulation of nitrofurantoin was increased markedly and nitrofurantoin BEI and in vitro Clbiliary were decreased to 11% and 14% of control, respectively. Digoxin values were unaffected by knockdown of Bcrp. Results indicated that Bcrp contributed predominantly to nitrofurantoin biliary excretion, but played a negligible role in digoxin biliary excretion. In summary, Bcrp knockdown in SCRH is the first in vitro model utilizing intact hepatocytes to assess the contribution of Bcrp to the biliary excretion of drugs. This approach may be useful in predicting drug-drug interactions in biliary excretion and the consequence of impaired BCRP function on the hepatic exposure of drugs/derived metabolites.
Generalized Unruh effect: A potential resolution to the black hole information paradox
Creators: name: Chen, Angela
Publisher: name: arXiv
Year: 2023
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We generalize the vacuum-Unruh effect to arbitrary excited states in the Fock space and find that the Unruh mode at the horizon induces coherent excitation on the canonical background ensemble measured by an accelerated observer. When there is only one type of Unruh mode in the system, for example, the ones outgoing from a black hole horizon, the mapping from an arbitrary density matrix on the maximal foliation to a vector space spanned by the pseudo-thermal density matrix on the partitioned spacetime wedge is one-to-one. Hence we propose that the information of the particles that are inside a collapsing shell, thus inside the asymptotic black hole horizon is at least partially retrievable by measuring the deviation of the Hawking radiation from the black body radiation spectrum. This work shows that the long-standing black hole information confusion might come from overlooking the possibility that the information could be preserved much better than we have expected in a seemingly non-unitary process when the partitions of the system are strongly entangled.
description: 27 pages, 6 figures, accepted by PRD
Galaxy population properties of the massive X-ray luminous galaxy cluster XDCP J0044.0-2033 at z=1.58: red-sequence formation, massive galaxy assembly, and central star formation activity
Creators: name: Fassbender, R.
name: Nastasi, A.
name: Santos, J. S.
name: Lidman, C.
name: Verdugo, M.
name: Koyama, Y.
name: Rosati, P.
name: Pierini, D.
name: Padilla, N.
name: Romeo, A. D.
name: Menci, N.
name: Bongiorno, A.
name: Castellano, M.
name: Cerulo, P.
name: Fontana, A.
name: Galametz, A.
name: Grazian, A.
name: Lamastra, A.
name: Pentericci, L.
name: Sommariva, V.
name: Strazzullo, V.
name: Suhada, R.
name: Tozzi, P.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We investigate various galaxy population properties of the massive X-ray luminous galaxy cluster XDCP J0044.0-2033 at z=1.58, which constitutes the most extreme matter density peak at this redshift currently known. We analyze deep VLT/HAWK-I NIR data in the J- and Ks-bands, complemented by Subaru imaging in i and V, Spitzer observations at 4.5 micron, and new spectroscopic observations with VLT/FORS2. We detect a cluster-associated excess population of about 90 galaxies, which follows a centrally peaked, compact NFW galaxy surface density profile with a concentration of c200~10. Based on the Spitzer 4.5 micron imaging data, we measure a stellar mass fraction of fstar,500=(3.3+-1.4)% consistent with local values. The total J- and Ks-band galaxy luminosity functions of the core region yield characteristic magnitudes J* and Ks* consistent with expectations from simple z_f=3 burst models. However, a detailed look at the morphologies and color distributions of the spectroscopically confirmed members reveals that the most massive galaxies are undergoing a very active mass assembly epoch through merging processes. Consequently, the bright end of the cluster red-sequence is not in place, while at intermediate magnitudes [Ks*,Ks*+1.6] a red-locus population is present, which is then sharply truncated at magnitudes fainter than Ks*+1.6. The dominant cluster core population comprises post-quenched galaxies transitioning towards the red-sequence at intermediate magnitudes, while additionally a significant blue cloud population of faint star-forming galaxies is present even in the densest central regions. Our observations lend support to the scenario in which the dominant effect of the dense z~1.6 cluster environment is an accelerated mass assembly timescale through merging activity that is responsible for driving core galaxies across the mass quenching threshold of log(Mstar/Msun)~10.4.
description: 23 pages, 19 color figures, accepted for publication in A&A, v2 matches journal version
Новые противоэрозионные влагосберегающие технологии и орудия для обработки почвы в условиях Узбекистана
Creators: name: Маматов Фармон Муртозевич
name: Мирзаев Бахадир Суюнович
Publisher: name: Экология и строительство
Year: 2017
Subjects: водная эрозия
водосбережение
технология
плуг
склон

description: Целью исследования является разработка технологии и технических средств для обработки почвы, способствующих влагосбережению и предотвращению водной эрозии на склоновых землях. Разработаны технологии обработки почв склонов, подверженных водной эрозии, принципиальные схемы и конструкции двухъярусного рыхлителя и плуга для гребнисто-ступенчатой вспашки. Результаты экспериментальных и хозяйственных испытаний разработанных орудий показали, что они по основным показателям работы существенно превосходит серийные машины, защищает почвы от водной эрозии, позволяет улучшить качество обработки почвы, снизить энергозатраты, повысить производительность агрегатов. При применении двухъярусного рыхлителя с наклонными стойками и плуга для гребнисто-ступенчатой вспашки соответственно затраты труда снижаются на 18,75 % и 14,4 %, расход топлива на 19,12 % и 14,25 %, производительность труда повышается на 18,96 % и 14,28 %.
title: Adopting wearables to customize health insurance contributions: a ranking-type Delphi
Creators: name: Neumann, Daniel
name: Tiberius, Victor
name: Biendarra, Florin
Publisher: name: Universitätsverlag Potsdam
Year: 2022
Subjects: subject: 610 Medizin und Gesundheit

description: Background Wearables, as small portable computer systems worn on the body, can track user fitness and health data, which can be used to customize health insurance contributions individually. In particular, insured individuals with a healthy lifestyle can receive a reduction of their contributions to be paid. However, this potential is hardly used in practice. Objective This study aims to identify which barrier factors impede the usage of wearables for assessing individual risk scores for health insurances, despite its technological feasibility, and to rank these barriers according to their relevance. Methods To reach these goals, we conduct a ranking-type Delphi study with the following three stages. First, we collected possible barrier factors from a panel of 16 experts and consolidated them to a list of 11 barrier categories. Second, the panel was asked to rank them regarding their relevance. Third, to enhance the panel consensus, the ranking was revealed to the experts, who were then asked to re-rank the barriers. Results The results suggest that regulation is the most important barrier. Other relevant barriers are false or inaccurate measurements and application errors caused by the users. Additionally, insurers could lack the required technological competence to use the wearable data appropriately. Conclusion A wider use of wearables and health apps could be achieved through regulatory modifications, especially regarding privacy issues. Even after assuring stricter regulations, users’ privacy concerns could partly remain, if the data exchange between wearables manufacturers, health app providers, and health insurers does not become more transparent.
description: Zweitveröffentlichungen der Universität Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe; 153
title: Franck Condon Factors and R-Centeroids for Six Diatomic Molecules
Creators: name: Fazio, Patricia M.
Publisher: name: Old Dominion University Libraries
Year: 1979

description: The Franck Condon factor is defined as the square of the overlap integral and is so named because of its ties with the Franck Condon Principle. The r-centroid is the internuclear separation associated with the electronic transition of the diatomic molecule. The physical meaning of these integrals is discussed. Two methods for construction of the wavefunctions are presented. Both methods employ the Morse Potential Energy function. The first method calculates the integrals using the analytic wavefunction of Morse and the second method has numerically constructed wavefunct!ons. The twelve transitions and six diatomic molecules studied include; B 2Σ+ to X 2π½ for AsO, A to X transition for NO+, C 3πu to B πg for N2 , A 2πi to X 2Σ+ for CO+, A 2π to X 2Σ for MgF and D 2Σ+ to X 2Σ+ for SrH. The results are compared with the published results of other methods.
MUX64, an analogue 64-to-1 multiplexer ASIC for the ATLAS High Granularity Timing Detector
Creators: name: Xu, Zifeng
name: Zhang, Li
name: Huang, Xing
name: Sha, Qiyu
name: Ge, Zhenwu
name: Che, Yimin
name: Gong, Datao
name: Hou, Suen
name: Zhang, Jie
name: Liu, Tiankuan
name: Liang, Zhijun
name: Zhang, Lei
name: Ye, Jingbo
name: Qi, Ming
Publisher: name: arXiv
Year: 2023
Subjects: subject: Instrumentation and Detectors (physics.ins-det)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: We present the design and the performance of MUX64, a 64-to-1 analogue multiplexer ASIC for the ATLAS High Granularity Timing Detector (HGTD). The MUX64 transmits one of its 64 inputs selected by six address lines for the voltages or temperatures being monitored to an lpGBT ADC channel. The prototype ASICs fabricated in TSMC 130 nm CMOS technology were prepared in wire-bonding and QFN88 packaging format. A total of 280 chips was examined for functionality and quality assurance. The accelerated aging test conducted at 85 degrees celsius shows negligible degradation over 16 days.
Effects of exposure to air and subsequent drying on the phosphate sorption characteristics of sediments from a eutrophic reservoir
Creators: name: Baldwin, D. S
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

The effects of exposure to air and subsequent drying on the phosphate adsorptive characteristics of sediments taken from Chaffey Dam - a small eutrophic water storage reservoir in New South Wales, Australia - were studied. Sediments were sampled along a transect that covered heavily desiccated, wet-littoral, and submerged sediments, both from above and below the oxycline. Phosphate adsorption isotherms showed that there was a definite transition in P affinity along the transect, with sediments taken from the driest sites displaying the least adsorptive capacity for phosphate and samples taken from beneath the oxycline the highest. A similar transition was observed for the kinetics of phosphate uptake. The order of reaction with respect to phosphate loading decreased from approximately first order for anoxic sediments to fractional order for desiccated sediments. These effects are mostly the result of sediment oxidation and aging rather than desiccation, variation in elemental composition, or differences in the amount of native P adsorbed to the sediment.
Coherent beam-beam experiments and implications for head-on compensation
Creators: name: White, S.
name: Blaskiewicz, M.
name: Fischer, W.
name: Luo, Y.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Accelerator Physics (physics.acc-ph)
subject: FOS: Physical sciences

description: In polarized proton operation in the Relativistic Heavy Ion Collider (RHIC) coherent beam-beam modes are routinely observed with beam transfer function measurements. These modes can become unstable under external excitation or in the presence of impedance. This becomes even more relevant in the presence of head-on compensation, which reduces the beam-beam tune spread and hence Landau damping. We report on experiments and simulations carried out to understand the impact of coherent modes on operation with electron lenses.
description: 8 pages, contribution to the ICFA Mini-Workshop on Beam-Beam Effects in Hadron Colliders, CERN, Geneva, Switzerland, 18-22 Mar 2013
Nonviral Methods for siRNA Delivery
Creators: name: Huang, Leaf
name: Gao, Kun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: RNA interference (RNAi) as a mechanism to selectively degrade messenger RNA (mRNA) expression has emerged as a potential novel approach for drug target validation and the study of functional genomics. Small interfering RNAs (siRNA) therapeutics has developed rapidly and already there are clinical trials ongoing or planned. Although other challenges remain, delivery strategies for siRNA become the main hurdle that must be resolved prior to the full-scale clinical development of siRNA therapeutics. This article provides an overview of the current delivery strategies for synthetic siRNA, focusing on the targeted, self-assembled nanoparticles which show potential to become a useful and efficient tool in cancer therapy.
A Study of Pre-flare Solar Coronal Magnetic Fields: Magnetic Energy and Helicity
Creators: name: Duan, Aiying
name: Jiang, Chaowei
name: Feng, Xueshang
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Solar flares fall into two types with eruptive ones associated with coronal mass ejection (CME) and confined ones without CME. To explore whether there are pre-flare conditions in terms of magnetic energy and helicity that can effectively determine the types of flares, here we analyzed a suite of related parameters of the reconstructed pre-flare coronal magnetic field of major solar flares, either eruptive or confined, from 2011 to 2017 near the solar disk center. The investigated parameters include the extensive-type quantities such as the total magnetic energy $E_T$, the potential energy $E_P$, the free energy $E_F$, the relative helicity $H_R$, and the non-potential helicity $H_J$, as well as the intensive-type indices $E_F/E_P$, $|H_J/H_R|$, $|H_R/ϕ^{\prime2}|$ and $|H_J/ϕ^{\prime2}|$, where $ϕ^{\prime}$ is half of the total unsigned magnetic flux. We have the following key findings: (1) None of the extensive parameters can effectively distinguish the eruptive and confined potential of the pre-flare coronal fields, though the confined events have averagely larger values; (2) All the intensive parameters have significantly larger average and median values for eruptive flares than the confined events, which indicates that the field for eruptive flares have overall higher degree of non-potentiality and complexity than that of the confined flares; (3) The energy ratio $E_F/E_P$ and the normalized non-potential helicity $|H_J/ϕ^{\prime2}|$, which are strongly correlated with each other, have among the highest capability of distinguishing the fields that possibly produce a major eruptive or confined flare, as over 75\% of all the events are successfully discriminated between eruptive and confined flares by using critical values of $E_F/E_P\ge0.27$ and $|H_J/ϕ^{\prime2}|\ge0.009$.
description: accepted by ApJ
Supplementary document for Multistatic Fiber-Based System for Measuring Mueller Matrix Bidirectional Reflectance Distribution Function - 6089981.pdf
Creators: name: Scarboro, Clifton
name: Kudenov, Michael
name: Doherty, Colleen
name: Balint-Kurti, Peter
Publisher: name: Optica Publishing Group
Year: 2022
Subjects: Uncategorized

description: Fabrication Methods and Additional Results Figures
Novel Cationic Lipid That Delivers siRNA and Enhances Therapeutic Effect in Lung Cancer Cells
Creators: name: Chen, Yunching
name: Bathula, Surendar Reddy
name: Huang, Leaf
name: Fittipaldi, Raffaella
name: Yang, Qi
name: Sen, Joyeeta
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: We have developed lipid–polycation–DNA (LPD) nanoparticles containing DOTAP and targeted with polyethylene glycol (PEG) tethered with anisamide (AA) to specifically deliver siRNA to H460 human lung carcinoma cells which express the sigma receptor. A novel non-glycerol based cationic lipid which contains both a guanidinium and a lysine residue as the cationic headgroup, i.e. DSGLA, downregulated pERK more efficiently in H460 cells than DOTAP. As demonstrated by using fluorescently labeled siRNA, LPD-PEG-AA prepared with DSGLA efficiently delivered siRNA to the cytoplasm of the H460 cells. Although the siRNA delivered by LPD-PEG-AA containing either DOTAP or DSGLA could effectively silence EGFR expression, a synergistic cell killing effect in promoting cellular apoptosis was only observed with DSGLA. The fluorescently labeled siRNA was efficiently delivered into the cytoplasm of H460 xenograft tumor by the LPD-PEG-AA containing either DOTAP or DSGLA 4 h after intravenous injection. Three daily injections (0.6 mg/kg) of siRNA formulated in the LPD-PEG-AA containing either DOTAP or DSGLA could effectively silence the epidermal growth factor receptor (EGFR) in the tumor, but the formulation containing DSGLA could induce more cellular apoptosis. A significant improvement in tumor growth inhibition was observed after dosing with LPD-PEG-AA containing DSGLA. Thus, DSGLA served as both a formulation component as well as a therapeutic agent which synergistically enhanced the activity of siRNA.
Parity-symmetry-adapted coherent states and entanglement in quantum phase transitions of vibron models
Creators: name: Calixto, M.
name: Romera, E.
name: del Real, R.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: We propose coherent (`Schrödinger catlike') states adapted to the parity symmetry providing a remarkable variational description of the ground and first excited states of vibron models for finite-($N$)-size molecules. Vibron models undergo a quantum shape phase transition (from linear to bent) at a critical value $ξ_c$ of a control parameter. These trial cat states reveal a sudden increase of vibration-rotation entanglement linear ($L$) and von Neumann ($S$) entropies from zero to $L^{(N)}_{\rm cat}(ξ)\simeq 1-{2}/{\sqrt{πN}}$ [to be compared with $L^{(N)}_{\rm max.}(ξ)=1-{1}/{(N+1)}$] and $S^{(N)}_{\rm cat}(ξ)\simeq \frac{1}{2} \log_2(N+1)$, respectively, above the critical point, $ξ>ξ_c$, in agreement with exact numerical calculations. We also compute inverse participation ratios, for which these cat states capture a sudden delocalization of the ground state wave packet across the critical point. Analytic expressions for entanglement entropies and inverse participation ratios of variational states, as functions of $N$ and $ξ$, are given in terms of hypergeometric functions.
description: 8 pages, 7 figures
Exploring the recycling model of Phobos formation: rubble-pile satellites
Creators: name: Madeira, Gustavo
name: Charnoz, Sebastien
name: Zhang, Yun
name: Hyodo, Ryuki
name: Michel, Patrick
name: Genda, Hidenori
name: Winter, Silvia Giuliatti
Publisher: name: arXiv
Year: 2023
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Phobos is the target of the return sample mission Martian Moons eXploration by JAXA that will analyze in great details the physical and compositional properties of the satellite from orbit, from the surface and in terrestrial laboratories, giving clues about its formation. Some models propose that Phobos and Deimos were formed after a giant impact giving rise to an extended debris disk. Assuming that Phobos formed from a cascade of disruptions and re-accretions of several parent bodies in this disk, and that they are all characterized by a low material cohesion, Hesselbrock & Milton (2017) have showed that a recycling process may happen during the assembling of Phobos, by which Phobos' parents are destroyed into a Roche-interior ring and reaccreted several times. In the current paper we explore in details the recycling model, and pay particular attention to the characteristics of the disk using 1D models of disk/satellite interactions. In agreement with previous studies we confirm that, if Phobos' parents bodies are gravitational aggregates (rubble piles), then the recycling process does occur. However, Phobos should be accompanied today by a Roche-interior ring. Furthermore, the characteristics of the ring are not reconcilable with today`s observations of Mars' environment, which put stringent constraints on the existence of a ring around Mars. The recycling mechanism may or may not have occurred at the Roche limit for an old moon population, depending on their internal cohesion. However, the Phobos we see today cannot be the outcome of such a recycling process.
description: Accept in The Astronomical Journal
Importance of Avidity for an Endogenous Drug Carrier: An Antibody Carrier for CpG Oligonucleotides
Creators: name: Cheung, Roland
name: Cho, Moo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: In animal models, successful anti-cancer monotherapy with CpG oligodeoxynucleotide (ODN) has been limited to the intratumoral and peritumoral routes of administration. To overcome this limitation, we developed a delivery system utilizing an endogenous antibody as a carrier for CpG ODNs. When a 1:1 conjugate of 2,4-dinitrophenyl (DNP) to a CpG ODN was administered to tumor-bearing mice that were pre-immunized against DNP, intravenous (IV) administration successfully inhibited tumor growth.1 In the present studies, we reproduced the IV results and showed that a DNP derivative of a controlled ODN with scrambled nucleotide sequence failed in the same model. Perhaps more significantly, contralateral subcutaneous (SC) routes of administration also suppressed tumor growth. However, in a separate experiment, when the anti-DNP titer level was low, the anti-tumor effect was abolished, supporting the importance of the avidity involved in the complexation. With the low titer, a significant fraction of injected dose must have existed as unbound that is subject to rapid clearance. The present study justifies chemically crosslink immune complexes such that the CpG ODN cannot dissociate in the body after administration.
Polarized light scattering with Paschen-Back effect, level-crossing of fine structure states and partial frequency redistribution
Creators: name: Sowmya, K.
name: Nagendra, K. N.
name: Sampoorna, M.
name: Stenflo, J. O.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: The quantum interference between the fine structure states of an atom modifies the shapes of the emergent Stokes profiles in the Second Solar Spectrum. This phenomenon has been studied in great detail both in the presence and absence of magnetic fields. By assuming a flat-spectrum for the incident radiation, the signatures of this effect have been explored for arbitrary field strengths. Even though the theory which takes into account the frequency dependence of the incident radiation is well developed, it is restricted to the regime in which the magnetic splitting is much smaller than the fine structure splitting. In the present paper, we carry out a generalization of our scattering matrix formalism including the effects of partial frequency redistribution (PRD) for arbitrary magnetic fields. We test the formalism using available benchmarks for special cases. In particular we apply it to the Li\,{\sc i} 6708\,Å D$_1$ and D$_2$ line system, for which observable effects from the Paschen-Back regime are expected in the Sun's spectrum.
description: 13 pages, 6 figures, accepted for publication in the ApJ