cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 7 of Exploring fine-scale urban landscapes using satellite data to predict the distribution of Aedes mosquito breeding sites
Creators: name: Teillet, Claire
name: Devillers, Rodolphe
name: Tran, Annelise
name: Catry, Thibault
name: Marti, Renaud
name: Dessay, Nadine
name: Rwagitinywa, Joseph
name: Restrepo, Johana
name: Roux, Emmanuel
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified

description: Supplementary Material 7
Tidally driven dynamos in a rotating sphere
Creators: name: Cébron, David
name: Hollerbach, Rainer
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Large-scale planetary or stellar magnetic fields generated by a dynamo effect are mostly attributed to flows forced by buoyancy forces in electrically conducting fluid layers. However, these large-scale fields may also be controlled by tides, as previously suggested for the star $τ$-boo, Mars or the Early Moon. By simulating a small local patch of a rotating fluid, \cite{Barker2014} have recently shown that tides can drive small-scale dynamos by exciting a hydrodynamic instability, the so-called elliptical (or tidal) instability. By performing global magnetohydrodynamic simulations of a rotating spherical fluid body, we investigate if this instability can also drive the observed large-scale magnetic fields. We are thus interested by the dynamo threshold and the generated magnetic field in order to test if such a mechanism is relevant for planets and stars. Rather than solving the problem in a geometry deformed by tides, we consider a spherical fluid body and add a body force to mimic the tidal deformation in the bulk of the fluid. This allows us to use an efficient spectral code to solve the magnetohydrodynamic problem. We first compare the hydrodynamic results with theoretical asymptotic results, and numerical results obtained in a truely deformed ellipsoid, which confirms the presence of the elliptical instability. We then perform magnetohydrodynamic simulations, and investigate the dynamo capability of the flow. Kinematic and self-consistent dynamos are finally simulated, showing that the elliptical instability is capable of generating dipole dominated large-scale magnetic field in global simulations of a fluid rotating sphere.
description: Astrophysical Journal Letters In press, (accepted) (2014) (accepted)
The association between insulin resistance and cytokines in adolescents: the role of weight status and exercise
Creators: name: McMurray, Robert G.
name: Thorpe, Deborah E.
name: Haqq, Andrea M.
name: Hackney, Anthony C.
name: Harrell, Joanne S.
name: Rubin, Daniela A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Increased adiposity is associated with insulin resistance (IR) and an inflammatory response in adults. We tested the hypotheses that cytokines associated with adiposity are also correlated with IR in early adolescents and that these relationships are moderated by weight status, levels of vigorous physical activity (VPA), or maximal aerobic power (pVO2max). Body mass, stature, and a fasting blood sample were obtained from 120 mid-pubertal adolescents (60 girls & 60 boys). Habitual VPA was obtained by a survey. Predicted VO2max was determined using a cycle-ergometer test. Weight status was based on body mass index percentiles (normal weight = BMI < 75th %tile and overweight = BMI > 95th %tile). Glucose, insulin, adiponectin, resistin, tumor necrosis factor-α, and interleukin-6 were measured, and IR index was based on the Homeostatic Model Assessment (HOMA). Adiponectin, resistin and TNF-α were associated with IR in all adolescents (R2=0.329, p<0.001, R2=0.152, p=0.001, R2=0.141, p=0.002; respectively), but IL-6 was not (R2=0.148, p=0.114). The degree of association between adiponectin and IR was stronger in overweight than in normal weight adolescents (p<0.050). When regression models included weight status, neither TNF-α nor resistin were significantly related to IR (p>0.050). Exercise did not moderate the association between these cytokines and IR. However, higher levels of VPA and/or pVO2max were associated with higher adiponectin, lower resistin and lower TNF- α in at least one of the genders. Our results indicate that the pathophysiology of obesity is already established in early adolescents. Increased adiposity, resulting in reduced adiponectin and increased resistin and TNF-α may link these cytokines with insulin resistance in adolescents.
Additional file 1 of Lithological structure of western Pacific lithosphere reconstructed from mantle xenoliths in a petit-spot volcano
Creators: name: Mikuni, Kazuto
name: Hirano, Naoto
name: Akizawa, Norikatsu
name: Yamamoto, Junji
name: Machida, Shiki
name: Tamura, Akihiro
name: Hagiwara, Yuuki
name: Morishita, Tomoaki
Publisher: name: figshare
Year: 2022
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: Additional file 1: Figure S1. Entire BSE images of the ultramafic xenolith. These were taken using SEM–EDS, Hitachi S-3400, at Tohoku University. The dark shadows are hardware artifacts. The grain cores of ultramafic xenoliths are compositionally homogeneous. Analyzed points are indicated by circles and arrows. The colors of the symbols indicate mineral species (yellow-green is olivine, green is clinopyroxene, orange is orthopyroxene, and red is spinel). (a) MPSX-PR1 peridotite, (b) MPSX-PR2 peridotite, (c) MPSX-PX1 pyroxenite, (d) MPSX-PX2 pyroxenite, (e) MPSX-PX3 pyroxenite, (f) MPSX-PX4 pyroxenite, (g) MPSX-PX5 pyroxenite, and (h) MPSX-PX6 clinopyroxene xenocryst.
Effects of an intensive behavioral weight loss intervention consisting of caloric restriction with or without physical activity on common carotid artery remodeling in severely obese adults
Creators: name: DeLany, James P.
name: Sutton-Tyrrell, Kim
name: Columbus, Mindy L.
name: Jakicic, John M.
name: Asubonteng, Julius
name: Barinas-Mitchell, Emma
name: Cooper, Jennifer N.
name: Meyer, Michelle L.
name: Shields, Kelly J.
name: Goodpaster, Bret H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2012

description: Obesity increases cardiovascular disease risk and adversely affects vascular structure and function. Few studies have evaluated the vascular effects of non-surgical weight reduction in the severely obese. We hypothesized that weight loss and improvements in cardiometabolic factors would reduce common carotid artery intima-media thickness (CIMT) and inter-adventitial diameter (AD) in severely obese adults.
Acoustic interaction forces and torques acting on suspended spheres in an ideal fluid
Creators: name: Lopes, J. Henrique
name: Azarpeyvand, M.
name: Silva, G. T.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Classical Physics (physics.class-ph)
subject: FOS: Physical sciences

description: In this paper, the acoustic interaction forces and torques exerted by an arbitrary time-harmonic wave on a set of N spheres suspended in an inviscid fluid are theoretically analyzed. In so doing, we utilize the partial-wave expansion method to solve the related multiple scattering problem. The acoustic interaction force and torque are computed for a sphere using the farfield radiation force and torque formulas. To exemplify the method, we calculate the interaction forces exerted by an external traveling and standing plane wave on an arrangement of two and three olive-oil droplets in water. The droplets radii are comparable to the wavelength (i.e. Mie scattering regime). The results show that the radiation force may considerably deviates from that exerted solely by the external incident wave. In addition, we find that acoustic interaction torques arise on the droplets when a nonsymmetric effective incident wave interacts with the droplets.
description: 13 pages, 10 figures, submitted to TUFFC-IEEE
Estimated plasma stearoyl co-A desaturase-1 activity and risk of incident diabetes: The Atherosclerosis Risk in Communities (ARIC) study
Creators: name: Pankow, James S.
name: Eckfeldt, John H.
name: Couper, David J.
name: Li, Shuzhen
name: Seaquist, Elizabeth R.
name: Eberly, Lynn E.
name: Steffen, Lyn M.
name: Hoogeveen, Ron C.
name: Chow, Lisa S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Evidence from pre-clinical studies suggests inhibition of Stearoyl Co-A Desaturase-1 (SCD-1) activity improves insulin sensitivity. Translation of these findings to humans remains less defined. The purpose of this research was to evaluate the association between different measures of SCD-1 activity and incident diabetes in a large, prospective human study.
title: Bumble bee queen production in semi-field studies: assessment of endpoints and challenges
Creators: name: Franke, L.
name: Klein, O.
name: Fricke, J.
name: Sorli, J.
name: Knaebe, S.
Publisher: name: Julius Kühn-Institut
Year: 2018

description: Bumble bees (Bombus terrestris L; Hymenoptera, Apidae) provide important pollination services and are commercially used, e.g. in greenhouse cultures. Consequently, the impacts of pesticides on bumble bees were already tested in the past. In the light of the newest EFSA guidance document on the risk assessment of plant protection products for pollinators standardized higher tier studies for pollinators are needed (EFSA 2013). For that reason a ringtest protocol for a bumble bee semi-field study design was developed in the ICPPR Non-Apis working group starting in 2015 to date.
The central endpoint in a higher tier bumble bee study is the colony reproduction success (production of young queens, Cabrera et al. 2016). The endpoint is chosen because at the end of the annual life cycle of a bumble bee colony all workers die and only young queens overwinter. Queens that survive establish a new colony in the following year. However, assessing queen reproduction is challenging. Many variables can influence the number of produced queens, such as the right timing for the termination of the study or the condition of the colony at study start. Furthermore, young queen weights are measured. Weight is used as indicator of diapause survival. Literature values of average weight needed for survival before overwintering state 0.8 g for a young queen for successful overwintering (Beekman et al. 1998).
Based on data from ring tests of 2016 and 2017 we tried to answer several open questions concerning queen reproduction, i.e. how can the experimental set-up influence queen weights and how high is the natural variation in queen numbers and queen weight/size?
description: Julius-Kühn-Archiv, Nr. 462 (2018): Hazards of pesticides to bees 13th International Symposium of the ICP-PR Bee Protection Group 18. - 20. October 2017, València (Spain) - Proceedings -
Coordination between cell size and chromatin structure
Creators: name: Martin, Lucie
Publisher: name: Imperial College London
Year: 2022

description: Cells change size during the cell cycle and in response to external conditions. In order to maintain biomolecule concentrations, gene expression is coordinated with cell size in a process called “scaling”. In fission yeast, scaling has been found to be associated with a genome-wide increase in transcription initiation rates and RNA polymerase II occupancy. However, the mechanistic details that underpin this global increase in transcription have not been defined yet. Since transcription initiation operates in the context of chromatin, we hypothesize that global transcriptional scaling is in part regulated by changes in chromatin state that reflect cell-size increase. To test this hypothesis, we used an analogue sensitive strain of the cyclin-dependent protein kinase Cdc2 (cdc2-asM17). Upon analogue treatment this strain exits the cell cycle in G2 and grows up to a size 3-4 times larger than wild-type after 6h of treatment. By mapping nucleosome occupancy in arrested cdc2-asM17 cells of increasing size, I uncover the link between cell size and the global chromatin architecture. More precisely, I show that cell size increase is accompanied by an increasing occupancy at promoters. These factors occupying the promoter in large cells are MNase-sensitive factors, suggesting that they are not canonical nucleosomes. Moreover, I report that a marker of transcription initiation, H3K9ac, scales with cell size, suggesting a possible role of this post-translational modification in setting a favorable context for an increasing occupancy at promoter of larger cells. Finally, comparing the genome wide distribution of H3 between normal and large cells reveals that for most genes, the protein complex occupying the promoter of large cells is not composed of H3, suggesting that they are not nucleosomal particles, although some promoters indeed present an enrichment of H3 upon cell size increase. Altogether, this work provides insights into the mechanism that regulates scaling.
Archaeological Reconnaissance of the Proposed Locality of a Thermal Test Facility on Sandia Base
Creators: name: Johnson, Carl B.
Publisher: name: Agency For Conservation Archaeology
Year: 1976
Subjects: subject: Bernalillo (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/3646/bernalillo-county
subject: Albuquerque, New Mexico
valueUri: https://core.tdar.org/browse/geographic-keyword/84765/albuquerque-new-mexico
subject: Kirtland Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/17943/kirtland-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/temporal-keyword/5728/historic
subject: Prehistoric
valueUri: https://core.tdar.org/browse/temporal-keyword/53/prehistoric
subject: Negative Result
valueUri: https://core.tdar.org/browse/other-keyword/76495/negative-result
subject: Cultural Resources Clearance
valueUri: https://core.tdar.org/browse/other-keyword/168090/cultural-resources-clearance
subject: Reconnaissance / Survey
valueUri: https://core.tdar.org/browse/investigation-type/7/reconnaissance-survey

description: The results of survey over a proposed construction site. No cultural resources were found during the reconnaissance.
Phenology of grassland plants responds to urbanization
Creators: name: Christmann, Tina
name: Kowarik, Ingo
name: Bernard-Verdier, Maud
name: Buchholz, Sascha
name: Hiller, Anne
name: Seitz, Birgit
name: Lippe, Moritz Von Der
Publisher: name: Technische Universität Berlin
Year: 2022
Subjects: subject: 577 Ökologie
subject: urban grassland
subject: flowering phenology
subject: urban biodiversity
subject: urban heat island
subject: urban-rural gradient
subject: reproductive phenology

description: Understanding phenological responses of plants to changing temperatures is important because of multiple associated ecological consequences. Cities with their urban heat island can be used as laboratories to study phenological adaptation to climate change. However, previous phenology studies focused on trees and did not disentangle the role of micro-climate and urban structures. We studied reproductive phenology of dry grassland species in response to micro-climate and urbanization in Berlin, Germany. Phenological stages were recorded weekly at the individual plant level for five native grassland species across 30 dry grassland sites along an urbanization and temperature gradient. We estimated 50% onset probabilities for flowering and seed maturation of populations, and analysed variation in onset dates using regression models. Early flowering species significantly advanced flowering phenology with increasing mean air temperature but were little influenced by urbanization. By contrast, late-flowering species showed significant phenological responses to both air temperature and urbanization, possibly because micro-climate was most affected by urbanization in late summer. Surprisingly, not all grassland species showed an advanced phenology with increasing intensity of urbanization. This contradicts observed patterns for urban trees, indicating that phenological shifts in urban areas cannot be generalized from the observation of one growth form or taxonomic group. Growth form appears as a possible determinant of phenological responses. Results suggest that the phenology of dry grassland species may directly respond to the urban heat island, albeit with variable direction and magnitude. This has implications for ecosystem services, shifted allergy seasons, changes of biogeochemical cycles and potential ecological mismatches.
Reexamining computer ethics in light of AI systems and AI regulation
Creators: name: Jacobs, Mattis
name: Simon, Judith
Publisher: name: Technische Universität Berlin
Year: 2022
Subjects: subject: 301 Soziologie, Anthropologie
subject: artificial intelligence
subject: AI ethics
subject: computer ethics
subject: value sensitive design
subject: regulation
subject: governance

description: This article argues that the emergence of AI systems and AI regulation showcases developments that have significant implications for computer ethics and make it necessary to reexamine some key assumptions of the discipline. Focusing on design- and policy-oriented computer ethics, the article investigates new challenges and opportunities that occur in this context. The main challenges concern how an AI system’s technical, social, political, and economic features can hinder a successful application of computer ethics. Yet, the article demonstrates that features of AI systems that potentially interfere with successfully applying some approaches to computer ethics are (often) only contingent, and that computer ethics can influence them. Furthermore, it shows how computer ethics can make use of how power manifests in an AI system’s technical, social, political, and economic features to achieve its goals. Lastly, the article outlines new interdependencies between policy- and design-oriented computer ethics, manifesting as either conflicts or synergies.
The early B-type eclipsing binary GT\,Cephei: a massive triple system?
Creators: name: Çakırlı, Ö.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: GT\,Cep is a semi-detached close binary system with an orbital period of 4.91 days, containing a massive star. I have obtained spectroscopic observations and derived radial velocities of both components. Combining the analyses of radial velocities and available photometric observations we have measured the absolute parameters of both components of GT\,Cep. The components are shown to be a B2\,V primary with a mass M$_p$=10.70$\pm$0.50 M$_{\odot}$ and radius R$_p$=6.83$\pm$0.19 R$_{\odot}$ and a A0\,IV secondary with a mass M$_s$=2.58$\pm$0.14 M$_{\odot}$ and radius R$_s$=7.56$\pm$0.21 R$_{\odot}$. My analyses show that GT\,Cep is a classical Algol-type binary with a less massive secondary filling its $Roche$ lobe. Using the UBVJHK magnitudes and the interstellar reddening of E(B-V)=0.61 I estimated the mean distance to the system as 854$\pm$43\,pc. The O-C residuals have been analyzed as the consequence of a light-time effect superimposed on an upward parabola. My analysis indicates that the eclipsing binary revolves around a third-body with a period of about 57.5 yr in an orbit with a radius of 40 $AU$. The lower limit for the mass of the third star has been estimated to be 7 M$_{\odot}$ for the inclination between $70^{o}$ and $90^{o}$.
description: 29 pages, 5 figures, Accepted by New Astronomy. arXiv admin note: text overlap with arXiv:1406.0334, arXiv:1406.0331
Additional file 2 of Lithological structure of western Pacific lithosphere reconstructed from mantle xenoliths in a petit-spot volcano
Creators: name: Mikuni, Kazuto
name: Hirano, Naoto
name: Akizawa, Norikatsu
name: Yamamoto, Junji
name: Machida, Shiki
name: Tamura, Akihiro
name: Hagiwara, Yuuki
name: Morishita, Tomoaki
Publisher: name: figshare
Year: 2022
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: Additional file 2: Figure S2. Representative data and example of the Raman microscopic analysis for CO2 fluid inclusion. (a) Raman spectrum of a CO2 fluid inclusion in MPSX-PX5 pyroxenite. The peaks of volatile species except for CO2 were lower than the detection limit of Raman spectroscopy. (b) An image of CO2 fluid inclusions in the same sample.
Cultural Resources Survey Department of Energy (DOE)/Transportation Safeguard Academy Test Well #1
Creators: name: Hayden, John S.
Year: 1987
Subjects: subject: Bernalillo (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/3646/bernalillo-county
subject: Albuquerque, New Mexico
valueUri: https://core.tdar.org/browse/geographic-keyword/84765/albuquerque-new-mexico
subject: Kirtland Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/17943/kirtland-air-force-base
subject: Negative Result
valueUri: https://core.tdar.org/browse/other-keyword/76495/negative-result
subject: Reconnaissance / Survey
valueUri: https://core.tdar.org/browse/investigation-type/7/reconnaissance-survey

description: This report documents the findings of a cultural resource survey for a proposed test well. The survey failed to reveal any evidence of cultural resources. However, it was recommended that surveyors reinvestigate the area.
Stress-first single photon emission computed myocardial perfusion imaging
Creators: name: Aquino, Carmen Imma
name: Scarano, Mariella
name: Squame, Fiorenzo
name: Casaburi, Giorgio
name: Nori, Stefania Lucia
name: Pace, Leonardo
Publisher: name: Universita' degli Studi di Salerno
Year: 2016
Subjects: Myocardial perfusion imaging
Coronary artery disease
Radiation dose
Stress-first

description: Background. Myocardial perfusion imaging (MPI) with single photon emission tomography (SPET) is widely used in coronary artery disease evaluation. Recently major dosimetric concerns have arisen. The aim of this study was to evaluate if a pre-test scoring system could predict the results of stress SPET MPI, thus avoiding two radionuclide injections. Methods. All consecutive patients (n=309) undergoing SPET MPI during the first 6 months of 2014 constituted the study group. The scoring system is based on these characteristics: age >65 years (1 point), diabetes (2 points), typical chest pain (2 points), congestive heart failure (3 points), abnormal ECG (4 points), male gender (4 points), and documented previous CAD (5 points). The patients were divided on the basis of the prediction score into 3 classes of risk for an abnormal stress-first protocol. Results. An abnormal stress SPET MPI was present in 7/31 patients (23%) with a low risk score, in 24/90 (27%) with an intermediate score risk, and in 124/188 (66%) with an high score risk. ROC curve analysis showed good prediction of abnormal stress MPI. Conclusions. Our results suggest an appropriate use of a pre-test clinical prediction formula of abnormal stress MPI in a routine clinical setting.
Intensive Archaeological Investigation of 22 Acres of Excess Land, Kirtland Air Force Base
Creators: name: Rodgers, James B.
Publisher: name: Center for Anthropological Studies, Albuquerque, NM
Year: 1980
Subjects: subject: Bernalillo (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/3646/bernalillo-county
subject: Albuquerque, New Mexico
valueUri: https://core.tdar.org/browse/geographic-keyword/84765/albuquerque-new-mexico
subject: Kirtland Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/17943/kirtland-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/temporal-keyword/5728/historic
subject: Prehistoric
valueUri: https://core.tdar.org/browse/temporal-keyword/53/prehistoric
subject: Negative Result
valueUri: https://core.tdar.org/browse/other-keyword/76495/negative-result
subject: Cultural Resources Clearance
valueUri: https://core.tdar.org/browse/other-keyword/168090/cultural-resources-clearance
subject: Reconnaissance / Survey
valueUri: https://core.tdar.org/browse/investigation-type/7/reconnaissance-survey

description: A survey of 22 acres at Kirtland Air Force Base resulting in no cultural resources discovered in the area.
Towards high-throughput metabolomics using ultrahigh-field Fourier transform ion cyclotron resonance mass spectrometry
Creators: name: Scarlett, Cameron O.
name: Zeisel, Steven
name: Han, Jun
name: Patel, Jayanti R.
name: Speir, J. Paul
name: Borchers, Christoph H.
name: Parker, Carol E.
name: Gumerov, Dmitry R.
name: Danell, Ryan M.
name: Rusyn, Ivan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: With unmatched mass resolution, mass accuracy, and exceptional detection sensitivity, Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FTICR-MS) has the potential to be a powerful new technique for high-throughput metabolomic analysis. In this study, we examine the properties of an ultrahigh-field 12-Tesla (12T) FTICR-MS for the identification and absolute quantitation of human plasma metabolites, and for the untargeted metabolic fingerprinting of inbred-strain mouse serum by direct infusion (DI). Using internal mass calibration (mass error ≤1 ppm), we determined the rational elemental compositions (incorporating unlimited C, H, N and O, and a maximum of two S, three P, two Na, and one K per formula) of approximately 250 out of 570 metabolite features detected in a 3-min infusion analysis of aqueous extract of human plasma, and were able to identify more than 100 metabolites. Using isotopically-labeled internal standards, we were able to obtain excellent calibration curves for the absolute quantitation of choline with sub-pmol sensitivity, using 500 times less sample than previous LC/MS analyses. Under optimized serum dilution conditions, chemical compounds spiked into mouse serum as metabolite mimics showed a linear response over a 600-fold concentration range. DI/FTICR-MS analysis of serum from 26 mice from 2 inbred strains, with and without acute trichloroethylene (TCE) treatment, gave a relative standard deviation (RSD) of 4.5%. Finally, we extended this method to the metabolomic fingerprinting of serum samples from 49 mice from 5 inbred strains involved in an acute alcohol toxicity study, using both positive and negative electrospray ionization (ESI). Using these samples, we demonstrated the utility of this method for high-throughput metabolomics, with more than 400 metabolites profiled in only 24 h. Our experiments demonstrate that DI/FTICR-MS is well-suited for high-throughput metabolomic analysis.
Energy absorption evaluation and design at the ballistic level in composites
Creators: name: Willows, Michelle
Publisher: name: Imperial College London
Year: 2019

description: The research presented in this thesis is directed towards the evaluation and understanding of a range of composite materials impacted at a ballistic level under both normal and oblique orientations, and the development of a novel recycled composite material with enhanced ballistic performance. It compares the ballistic performance of normal and oblique impacts of metallic and composite materials, describes the development, production and testing of a novel recycled composite material, and the performance of a Kolsky experiment on this novel material. For the Certification Authorities within the Aerospace Industry, the effects of angled impacts onto composites have not been addressed to the same extent as normal impacts, primarily because perpendicular impacts are largely considered to be the worst case scenarios. However, this research highlights certain aspects within the behaviour of composite materials in which that assumption may be too simplistic. Composites offer many advantages in ballistic protection but they are still relatively expensive and once damaged the ‘used’ material is usually discarded in secure landfill or burnt, and new pristine protective panels are required in their place. The development of a new recycled composite material could potentially therefore reduce costs, for example, if employed in partly replacing current battle-damaged polymeric armour panels used in the protection of air/land/sea vehicles, equipment and buildings. Further insight has been gained through the implementation of a Kolsky bar impact test based on a Hopkinson bar methodology, which has been modified to encompass a Taylor impact type concept. In this test, a polymeric specimen is fired against an instrumented steel bar, which measures the strain generated during the impact event, and the process of material deformation and disintegration is captured on video for subsequent analysis. Tests have been carried out on Aluminium, pristine cylindrical and cuboid Dyneema® specimens and also recycled cylindrical Dyneema® specimens.
Additional file 14 of Adiposity and mortality among intensive care patients with COVID-19 and non-COVID-19 respiratory conditions: a cross-context comparison study in the UK
Creators: name: Bell, Joshua A.
name: Carslake, David
name: Hughes, Amanda
name: Tilling, Kate
name: Dodd, James W.
name: Doidge, James C.
name: Harrison, David A.
name: Rowan, Kathryn M.
name: Davey Smith, George
Publisher: name: figshare
Year: 2024
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 14: Figure S14 Association between BMI and mortality in COVID-19 and non-COVID-19 respiratory patients, by admission date.
Mechanism of cell death in enteropathogenic Escherichia coli-infected colorectal cancer cell
Creators: name: Zhong, Qiyun
Publisher: name: Imperial College London
Year: 2022

description: Programmed cell death pathways are crucial for maintaining homeostasis, eliminating damaged or diseased cells before they can cause harm. Thus, the understanding of the mechanisms involved in these pathways is necessary for future therapeutic development. Pyroptosis, a pro-inflammatory lytic form of cell death, restricts the growth of both pathogens and cancer cells and effectively stimulates immune responses. In this study I characterised the mechanism resulting in pyroptosis of colorectal cancer cell (CRC) lines infected by a tumour-colonising bacterium, enteropathogenic Escherichia coli (EPEC). EPEC uses a type III secretion system to inject virulence factors, called effectors, into the host cytosol. The translocated intimin receptor (Tir), an essential effector that inserts into the host plasma membrane and binds to the bacterial outer membrane protein intimin to establish the intimate attachment of the bacteria, activates pyroptosis in CRC cells. Pyroptosis is initiated by Tir-dependent extracellular Ca2+ influx through the mechanosensitive cation channel TRPV2, followed by the internalisation of the bacterial cell wall component lipopolysaccharide (LPS). Cytosolic LPS can be recognised by caspase-4, which then cleaves and activates the pore-forming protein gasdermin D to facilitate cell lysis. As pyroptosis and its downstream immune stimulation is detrimental to EPEC colonisation, multiple other bacterial effectors are employed to counteract pyroptosis at different stages. Importantly, this Tir-dependent cell death mechanism is largely conserved among the caspase-4- and GSDMD-expressing CRC cells of different genetic backgrounds. This study identifies a novel bacterial virulence factor-mediated pyroptotic mechanism effective in killing CRC cells that could potentially be exploited for future cancer therapy development.
Additional file 3 of Lithological structure of western Pacific lithosphere reconstructed from mantle xenoliths in a petit-spot volcano
Creators: name: Mikuni, Kazuto
name: Hirano, Naoto
name: Akizawa, Norikatsu
name: Yamamoto, Junji
name: Machida, Shiki
name: Tamura, Akihiro
name: Hagiwara, Yuuki
name: Morishita, Tomoaki
Publisher: name: figshare
Year: 2022
Subjects: subject: Geology
subject: FOS: Earth and related environmental sciences

description: Additional file 3. Supplementary information about the numerical process. The method of error calculation for the two pyroxene thermometry of Brey and Köhler (1990), the two pyroxene thermobarometry using the equation (36) and (38) of Putirka (2008), and the geobarometry of CO2 inclusion in pyroxene by Raman spectroscopy are described. The process of depth-pressure conversion is also attached.
$N$-point free energy distribution function in one dimensional random directed polymers
Creators: name: Dotsenko, V.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: Explicit expression for the $N$-point free energy distribution function in one dimensional directed polymers in a random potential is derived in terms of the Bethe ansatz replica technique. The obtained result is equivalent to the one derived earlier by Prolhac and Spohn [J. Stat. Mech., 2011, P03020].
description: 10 pages, 1 figure
Metabolic assessment of a novel chronic myelogenous leukemic cell line and an imatinib resistant subline by 1H NMR spectroscopy
Creators: name: Dzeja, Petras
name: Macdonald, Jeffrey M.
name: Keshari, Kayvan
name: Graves, Lee M.
name: Dewar, Brian J.
name: Jeffries, Rex
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: The goal of this study was to examine metabolic differences between a novel chronic myelogenous leukemic (CML) cell line, MyL, and a sub-clone, MyL-R, which displays enhanced resistance to the targeted Bcr-Abl tyrosine kinase inhibitor imatinib. 1H nuclear magnetic resonance (NMR) spectroscopy was carried out on cell extracts and conditioned media from each cell type. Both principal component analysis (PCA) and specific metabolite identification and quantification were used to examine metabolic differences between the cell types. MyL cells showed enhanced glucose removal from the media compared to MyL-R cells with significant differences in production rates of the glycolytic end-products, lactate and alanine. Interestingly, the total intracellular creatine pool (creatine + phosphocreatine) was significantly elevated in MyL-R compared to MyL cells. We further demonstrated that the MyL-R cells converted the creatine to phosphocreatine using non-invasive monitoring of perfused alginate-encapsulated MyL-R and MyL cells by in vivo 31P NMR spectroscopy and subsequent HPLC analysis of extracts. Our data demonstrated a clear difference in the metabolite profiles of drug-resistant and sensitive cells, with the biggest difference being an elevation of creatine metabolites in the imatinib-resistant MyL-R cells.
An umbrella review of physical literacy modelling
Creators: name: Fenton, Sam
name: Dabkowski, Elissa
name: Porter, Joanne
name: Fletcher, Anna
name: Prins, Alex
Publisher: name: Federation University Australia
Year: 2022
Subjects: Sports science and exercise not elsewhere classified
Community child health
Public health not elsewhere classified
Social determinants of health

description: Attached is our protocol for an umbrella review on physical literacy models.
On non-disk geometry of r = 0 in Kerr-de Sitter and Kerr-Newman-de Sitter spacetimes
Creators: name: Manko, V. S.
name: Garcia-Compean, H.
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Gaussian curvature of the two-surface r=0, t=const is calculated for the Kerr-de Sitter and Kerr-Newman-de Sitter solutions, yielding non-zero analytical expressions for both the cases. The results obtained, on the one hand, exclude the possibility for that surface to be a disk and, on the other hand, permit one to establish a correct geometrical interpretation of that surface for each of the two solutions.
description: 11 pages, 4 figures
Additional file 1 of Non-suicidal self-injury and its relation to suicide through acquired capability: investigating this causal mechanism in a mainly late-diagnosed autistic sample
Creators: name: Moseley, Rachel L.
name: Gregory, Nicola J.
name: Smith, Paula
name: Allison, Carrie
name: Cassidy, Sarah
name: Baron-Cohen, Simon
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Biotechnology
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Computational Biology

description: Additional file 1. Supplementary data analysis.
Recurring automated model calibration for dynamically adaptive water distribution networks
Creators: name: Waldron, Alexander Joseph
Publisher: name: Imperial College London
Year: 2021

description: The ability to build and maintain accurate hydraulic models in the water industry is a challenge of increasing importance as the applications of these models are used for short-term operational management, as well as strategic infrastructure investment and repair decisions. However, uncertainties are introduced into hydraulic models as water networks evolve over time, both in terms of physical degradation and changing consumer demand within urban environments. The process of calibrating and validating the hydraulic model can bring back confidence to the end user, but it is traditionally only undertaken on an ad hoc basis as it is a labour intensive and expensive exercise with frequently questionable results. This thesis utilises the ever-increasing quantity and quality of hydraulic data to develop robust and efficient model fitting methods for the purpose of hydraulic model calibration. Furthermore, data from long-term telemetry systems is used, together with advanced control, to study automatic and recurrent model validation for the continuous maintenance of dynamically adaptive networks. Methods for model calibration have been extensively discussed in previously published literature. However, there have been key limitations, which were exacerbated by using theoretical water networks with fictitious data. These case studies often disregard the constraints of an operational model from the water industry, hence an underlying principle of this work is to implement advanced calibration procedures on operational networks and investigate the level of accuracy that can be achieved. Investigations into reducing the ill-posedness of the problem and its scalability are also undertaken. Passive and active data sampling approaches are developed for continuously maintaining and improving the accuracy of the hydraulic model. Passive data sampling approaches use machine learning techniques to sample hydraulic data streams over an extended period, utilising natural variations and changes in control to improve the prediction accuracy of the hydraulic model. Active data sampling approaches involve optimally modifying hydraulic conditions via remotely actuated valves within dynamically adaptive networks for the purpose of improving the prediction accuracy of the hydraulic model. Three large case studies that provide hydraulic data with high temporal and spatial resolution are used as unique test areas for implementing the methods presented in the thesis. Using these methods, water companies can now recurrently validate and maintain their models, and as data and control become more ubiquitous, the process of automatic recurrent model validation will be further enhanced.
A targeted metabolomic protocol for short-chain fatty acids and branched-chain amino acids
Creators: name: Qiu, Yunping
name: Jia, Wei
name: Li, Qiong
name: Qiao, Shanlei
name: Zhou, Zhanxiang
name: Zhong, Wei
name: Zhao, Aihua
name: Ore, Brandon M.
name: Zeisel, Steven H.
name: Xie, Guoxiang
name: Su, Mingming
name: Zheng, Xiaojiao
name: Spencer, Melanie D.
name: Baxter, Sarah
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Research in obesity and metabolic disorders that involve intestinal microbiota demands reliable methods for the precise measurement of the short-chain fatty acids (SCFAs) and branched-chain amino acids (BCAAs) concentration. Here, we report a rapid method of simultaneously determining SCFAs and BCAAs in biological samples using propyl chloroformate (PCF) derivatization followed by gas chromatography mass spectrometry (GC-MS) analysis. A one-step derivatization using 100 µL of PCF in a reaction system of water, propanol, and pyridine (v/v/v = 8:3:2) at pH 8 provided the optimal derivatization efficiency. The best extraction efficiency of the derivatized products was achieved by a two-step extraction with hexane. The method exhibited good derivatization efficiency and recovery for a wide range of concentrations with a low limit of detection for each compound. The relative standard deviations (RSDs) of all targeted compounds showed good intra- and inter-day (within 7 days) precision (< 10%), and good stability (< 20%) within 4 days at room temperature (23–25 °C), or 7 days when stored at −20 °C. We applied our method to measure SCFA and BCAA levels in fecal samples from rats administrated with different diet. Both univariate and multivariate statistics analysis of the concentrations of these target metabolites could differentiate three groups with ethanol intervention and different oils in diet. This method was also successfully employed to determine SCFA and BCAA in the feces, plasma and urine from normal humans, providing important baseline information of the concentrations of these metabolites. This novel metabolic profile study has great potential for translational research.
Non-targeted metabolomics analysis of cardiac Muscle Ring Finger-1 (MuRF1), MuRF2, and MuRF3 in vivo reveals novel and redundant metabolic changes
Creators: name: Spaniel, Carolyn
name: Willis, Monte S.
name: Quintana, Megan T.
name: Muehlbauer, Michael J.
name: He, Jun
name: Banerjee, Ranjan
name: Wang, Zhongjing
name: Newgard, Christopher B.
name: Bain, James R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The muscle-specific ubiquitin ligases MuRF1, MuRF2, MuRF3 have been reported to have overlapping substrate specificities, interacting with each other as well as proteins involved in metabolism and cardiac function. In the heart, all three MuRF family proteins have proven critical to cardiac responses to ischemia and heart failure. The non-targeted metabolomics analysis of MuRF1-/-, MuRF2-/-, and MuRF3-/- hearts was initiated to investigate the hypothesis that MuRF1, MuRF2, and MuRF3 have a similarly altered metabolome, representing alterations in overlapping metabolic processes. Ventricular tissue was flash frozen and quantitatively analyzed by GC/MS using a library built upon the Fiehn GC/MS Metabolomics RTL Library. Non-targeted metabolomic analysis identified significant differences (via VIP statistical analysis) in taurine, myoinositol, and stearic acid for the three MuRF-/- phenotypes relative to their matched controls. Moreover, pathway enrichment analysis demonstrated that MuRF1-/- had significant changes in metabolite(s) involved in taurine metabolism and primary acid biosynthesis while MuRF2-/- had changes associated with ascorbic acid/aldarate metabolism (via VIP and t-test analysis vs. sibling-matched wildtype controls). By identifying the functional metabolic consequences of MuRF1, MuRF2, and MuRF3 in the intact heart, non-targeted metabolomics analysis discovered common pathways functionally affected by cardiac MuRF family proteins in vivo. These novel metabolomics findings will aid in guiding the molecular studies delineating the mechanisms that MuRF family proteins regulate metabolic pathways. Understanding these mechanism is an important key to understanding MuRF family proteins' protective effects on the heart during cardiac disease.
Cultural Resource Survey of 50 Acres and Update of LA 152577 on Kirtland Air Force Base, Bernalillo County, New Mexico
Creators: name: Unruh, David
name: Sisneros, Brianne
name: Walth, Cherie K.
Publisher: name: swca environmental consultants
Year: 2018
Subjects: subject: Tijeras Canyon
valueUri: https://core.tdar.org/browse/geographic-keyword/85726/tijeras-canyon
subject: Bernalillo (County)
valueUri: https://core.tdar.org/browse/geographic-keyword/3646/bernalillo-county
subject: Albuquerque, New Mexico
valueUri: https://core.tdar.org/browse/geographic-keyword/84765/albuquerque-new-mexico
subject: Tijeras Arroyo
valueUri: https://core.tdar.org/browse/geographic-keyword/82692/tijeras-arroyo
subject: Kirtland Air Force Base
valueUri: https://core.tdar.org/browse/geographic-keyword/17943/kirtland-air-force-base
subject: Historic
valueUri: https://core.tdar.org/browse/temporal-keyword/5728/historic
subject: Prehistoric
valueUri: https://core.tdar.org/browse/temporal-keyword/53/prehistoric
subject: PaleoIndian
valueUri: https://core.tdar.org/browse/culture-keyword/4/paleoindian
subject: Folsom
valueUri: https://core.tdar.org/browse/culture-keyword/6/folsom
subject: Archaic
valueUri: https://core.tdar.org/browse/culture-keyword/8/archaic
subject: Early Archaic
valueUri: https://core.tdar.org/browse/culture-keyword/9/early-archaic
subject: Middle Archaic
valueUri: https://core.tdar.org/browse/culture-keyword/10/middle-archaic
subject: LA 38138
valueUri: https://core.tdar.org/browse/site-name/130439/la-38138
subject: LA 152577
valueUri: https://core.tdar.org/browse/site-name/133259/la-152577
subject: Multi-component site
valueUri: https://core.tdar.org/browse/site-type/2193/multi-component-site
subject: Artifact Scatter
valueUri: https://core.tdar.org/browse/site-type/340/artifact-scatter
subject: Chipped Stone
valueUri: https://core.tdar.org/browse/material-type/2/chipped-stone
subject: Ground Stone
valueUri: https://core.tdar.org/browse/material-type/7/ground-stone
subject: Pedestrian Survey
valueUri: https://core.tdar.org/browse/other-keyword/9852/pedestrian-survey
subject: Reconnaissance / Survey
valueUri: https://core.tdar.org/browse/investigation-type/7/reconnaissance-survey
subject: Records Search / Inventory Checking
valueUri: https://core.tdar.org/browse/investigation-type/8/records-search-inventory-checking

description: This report presents the results of an intensive archaeological pedestrian survey of 50 acres surrounding LA 152577 within the Kirtland Air Force Base property in Bernalillo County, New Mexico. The project is was completed under Prudent’s Fence-to-Fence Environmental Services at Kirtland Air Force Base, New Mexico. The project is located north of Munition Haul Road, along the south side of the confluence of Tijeras Arroyo and Arroyo del Coyote on Kirtland Air Force Base property in Bernalillo County, New Mexico. One multicomponent archaeological site (LA 152577) was updated during the project.