cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
60693: Photographs of Private Albert George Reed M.M.
Creators: name: Project Team, Great War Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Brother of Caroline Austin, brother-in-law of Thomas Richard Austin. He served with the Leicestershire Regiment, and was awarded Military Medal. Killed July 5th 1917, he is buried at Metz-en Couture Communal Cemetery, Pas de Calais.
My grandmother's brother, to whom she sent a card of her and her two children, which was returned with his effects. He is so handsome, cocky, full of life! In the group photo I think it is he, near the back on the left of the column, in a light suit.

Editor's Comment:

Three single shots and one group photograph of men in Hospital 'Blues' Uniform.
Private 15249 Albert George Reed, M.M., 2nd/5th Bn. Leicestershire Regiment, was killed in action 5th July 1917, aged 25. The son of Joseph and Mary Ann Reed, of 61, Rodney St., Swansea, he is buried in Metz-en-Couture Communal Cemetery British Extension.
Additional file 1 of Seizure semiology and predictors of outcomes in Chinese patients with glutamic acid decarboxylase antibody-associated neurological syndrome
Creators: name: Lin, Nan
name: Bai, Lin
name: Liu, Qing
name: Chen, Jianhua
name: Ren, Haitao
name: Guan, Hongzhi
name: Lu, Qiang
Publisher: name: figshare
Year: 2024
Subjects: subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1: Table S1. Clinical characteristics and treatments. Table S2. Treatments and outcome in anti-GAD encephalitis.
Heavy-tailed prior distributions for sequence count data: removing the noise and preserving large differences
Creators: name: Love, Michael I
name: Zhu, Anqi
name: Ibrahim, Joseph G
Publisher: name: Oxford University Press (OUP)
Year: 2018

description: MOTIVATION: In RNA-seq differential expression analysis, investigators aim to detect those genes with changes in expression level across conditions, despite technical and biological variability in the observations. A common task is to accurately estimate the effect size, often in terms of a logarithmic fold change (LFC). RESULTS: When the read counts are low or highly variable, the maximum likelihood estimates for the LFCs has high variance, leading to large estimates not representative of true differences, and poor ranking of genes by effect size. One approach is to introduce filtering thresholds and pseudocounts to exclude or moderate estimated LFCs. Filtering may result in a loss of genes from the analysis with true differences in expression, while pseudocounts provide a limited solution that must be adapted per dataset. Here, we propose the use of a heavy-tailed Cauchy prior distribution for effect sizes, which avoids the use of filter thresholds or pseudocounts. The proposed method, Approximate Posterior Estimation for generalized linear model, apeglm, has lower bias than previously proposed shrinkage estimators, while still reducing variance for those genes with little information for statistical inference. AVAILABILITY AND IMPLEMENTATION: The apeglm package is available as an R/Bioconductor package at https://bioconductor.org/packages/apeglm, and the methods can be called from within the DESeq2 software. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
64515: The Cottage
Creators: name: Project Team, First World War Poetry Digital Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Here in turn succeed and rule
 Carter, smith, and village fool,
 Then again the place is known
 As tavern, shop, and Sunday-school;
 Now somehow it's come to me
 To light the fire and hold the key,
 Here in Heaven to reign alone.
 All the walls are white with lime,
 Big blue periwinkles climb
 And kiss the crumbling window-sill;
 Snug inside I sit and rhyme,
 Planning poem, book, or fable,
 At my darling beech-wood table
 Fresh with bluebells from the hill.
 Through the window I can see
 Rooks above the cherry-tree,
 Sparrows in the violet bed,
 Bramble-bush and bumble-bee,
 And old red bracken smoulders still
 Among boulders on the hill,
 Far too bright to seem quite dead.
 But old Death, who can't forget,
 Waits his time and watches yet,
 Waits and watches by the door.
 Look, he's got a great new net,
 And when my fighting starts afresh
 Stouter cord and smaller mesh
 Won't be cheated as before.
 Nor can kindliness of Spring,
 Flowers that smile nor birds that sing,
 Bumble-bee nor butterfly,
 Nor grassy hill nor anything
 Of magic keep me safe to rhyme
 In this Heaven beyond my time.
 No! for Death is waiting by.
sj-docx-1-phr-10.1177_00333549221142571 – Supplemental material for Pregnant Women’s Experiences During and After Hurricanes Irma and Maria, Pregnancy Risk Assessment Monitoring System, Puerto Rico, 2018
Creators: name: Simeone, Regina M.
name: House, L. Duane
name: Salvesen von Essen, Beatriz
name: Kortsmit, Katherine
name: Hernandez Virella, Wanda
name: Vargas Bernal, Manuel I.
name: Galang, Romeo R.
name: D’Angelo, Denise V.
name: Shapiro-Mendoza, Carrie K.
name: Ellington, Sascha R.
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental material, sj-docx-1-phr-10.1177_00333549221142571 for Pregnant Women’s Experiences During and After Hurricanes Irma and Maria, Pregnancy Risk Assessment Monitoring System, Puerto Rico, 2018 by Regina M. Simeone, L. Duane House, Beatriz Salvesen von Essen, Katherine Kortsmit, Wanda Hernandez Virella, Manuel I. Vargas Bernal, Romeo R. Galang, Denise V. D’Angelo, Carrie K. Shapiro-Mendoza and Sascha R. Ellington in Public Health Reports
A critical overview of computational approaches employed for COVID-19 drug discovery
Creators: name: Brown, Nathan
name: Merz, Kenneth M.
name: Todd, Matthew H.
name: Medina-Franco, Jose L.
name: Ekins, Sean
name: Zakharov, Alexey V.
name: Cherkasov, Artem
name: Muratov, Eugene N.
name: Kozakov, Dima
name: Andrade, Carolina H.
name: Varnek, Alexandre
name: Fourches, Denis
name: Poroikov, Vladimir
name: Amaro, Rommie
name: Winkler, David A.
name: Isayev, Olexandr
name: Oprea, Tudor I.
name: Tropsha, Alexander
name: Schneider, Gisbert
Publisher: name: Royal Society of Chemistry (RSC)
Year: 2021

description: COVID-19 has resulted in huge numbers of infections and deaths worldwide and brought the most severe disruptions to societies and economies since the Great Depression. Massive experimental and computational research effort to understand and characterize the disease and rapidly develop diagnostics, vaccines, and drugs has emerged in response to this devastating pandemic and more than 130000 COVID-19-related research papers have been published in peer-reviewed journals or deposited in preprint servers. Much of the research effort has focused on the discovery of novel drug candidates or repurposing of existing drugs against COVID-19, and many such projects have been either exclusively computational or computer-aided experimental studies. Herein, we provide an expert overview of the key computational methods and their applications for the discovery of COVID-19 small-molecule therapeutics that have been reported in the research literature. We further outline that, after the first year the COVID-19 pandemic, it appears that drug repurposing has not produced rapid and global solutions. However, several known drugs have been used in the clinic to cure COVID-19 patients, and a few repurposed drugs continue to be considered in clinical trials, along with several novel clinical candidates. We posit that truly impactful computational tools must deliver actionable, experimentally testable hypotheses enabling the discovery of novel drugs and drug combinations, and that open science and rapid sharing of research results are critical to accelerate the development of novel, much needed therapeutics for COVID-19.
Additional file 1 of Dual spatially resolved transcriptomics for human host–pathogen colocalization studies in FFPE tissue sections
Creators: name: Sounart, Hailey
name: Lázár, Enikő
name: Masarapu, Yuvarani
name: Wu, Jian
name: Várkonyi, Tibor
name: Glasz, Tibor
name: Kiss, András
name: Borgström, Erik
name: Hill, Andrew
name: Rezene, Sefanit
name: Gupta, Soham
name: Jurek, Aleksandra
name: Niesnerová, Anezka
name: Druid, Henrik
name: Bergmann, Olaf
name: Giacomello, Stefania
Publisher: name: figshare
Year: 2024
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Fig. S1 - S17. Table S3. Confusion matrix comparing RNAScope and ST SARS-CoV-2 S gene signal. The confusion matrix is generated from 300 µm disk areas used in the quantitative validation analysis that determines the SARS-CoV-2 S gene signal in each area for RNAScope and our ST approach.
Supplemental Material - Recovery from Alcohol Use Disorder among Older Adults: A Scoping Review
Creators: name: Kermel-Schiffman, Ile
name: Afuta, May
name: Zur, Amit
name: Gavriel-Fried, Belle
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: 110308 Geriatrics and Gerontology
subject: 111799 Public Health and Health Services not elsewhere classified
subject: FOS: Health sciences

description: Supplemental Material for Recovery from Alcohol Use Disorder among Older Adults: A Scoping Review by Ile Kermel-Schiffman, May Afuta, Amit Zur, and Belle Gavriel-Fried in Journal of Applied Gerontology
sj-docx-1-asm-10.1177_10731911221141873 – Supplemental material for Optimizing the Assessment of Parental Burnout: A Multi-informant and Multimethod Approach to Determine Cutoffs for the Parental Burnout Inventory and the Parental Burnout Assessment
Creators: name: Brianda, Maria Elena
name: Mikolajczak, Moïra
name: Bader, Michel
name: Bon, Sandra
name: Déprez, Alexandra
name: Favez, Nicolas
name: Holstein, Liliane
name: Le Vigouroux, Sarah
name: Lebert-Charron, Astrid
name: Sánchez-Rodríguez, Raquel
name: Séjourné, Natalène
name: Wendland, Jaqueline
name: Roskam, Isabelle
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology

description: Supplemental material, sj-docx-1-asm-10.1177_10731911221141873 for Optimizing the Assessment of Parental Burnout: A Multi-informant and Multimethod Approach to Determine Cutoffs for the Parental Burnout Inventory and the Parental Burnout Assessment by Maria Elena Brianda, Moïra Mikolajczak, Michel Bader, Sandra Bon, Alexandra Déprez, Nicolas Favez, Liliane Holstein, Sarah Le Vigouroux, Astrid Lebert-Charron, Raquel Sánchez-Rodríguez, Natalène Séjourné, Jaqueline Wendland and Isabelle Roskam in Assessment
A Bayesian approach to comparing common models of life-course epidemiology
Creators: name: Harris, Kathleen M
name: Shanahan, Michael
name: Chumbley, Justin
name: Potente, Cecilia
name: Xu, Wenjia
Publisher: name: Oxford University Press (OUP)
Year: 2021

description: BACKGROUND: Life-course epidemiology studies people's health over long periods, treating repeated measures of their experiences (usually risk factors) as predictors or causes of subsequent morbidity and mortality. Three hypotheses or models often guide the analyst in assessing these sequential risks: the accumulation model (all measurement occasions are equally important for predicting the outcome), the critical period model (only one occasion is important) and the sensitive periods model (a catch-all model for any other pattern of temporal dependence). METHODS: We propose a Bayesian omnibus test of these three composite models, as well as post hoc decompositions that identify their best respective sub-models. We test the approach via simulations, before presenting an empirical example that relates five sequential measurements of body weight to an RNAseq measure of colorectal-cancer disposition. RESULTS: The approach correctly identifies the life-course model under which the data were simulated. Our empirical cohort study indicated with >90% probability that colorectal-cancer disposition reflected a sensitive process, with current weight being most important but prior body weight also playing a role. CONCLUSIONS: The Bayesian methods we present allow precise inferences about the probability of life-course models given the data and are applicable in realistic scenarios involving causal analysis and missing data.
66004: La Gorgues
Creators: name: Project Team, First World War Poetry Digital Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Typescript without alterations, prepared by Marion Scott, and possibly amongst those poems submitted to and rejected by the firm Sidgwick and Jackson in 1922. Another version of the poem entitled 'La Gorgue' appears in P.J. Kavanagh's 'Ivor Gurney: Collected Poems' (2004) with numerous minor changes to lines and punctuation.
sj-pdf-1-vmj-10.1177_1358863X221148797 – Supplemental material for Use of telemedicine facilitated by trained telepresenters to manage advanced peripheral artery disease in rural areas
Creators: name: Breen, Thomas J
name: Peake, James B
name: Keefe, Heidi
name: Moran, Justine
name: Kunjukutty, Felix
name: Pfau, Steven
name: Altin, S Elissa
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: Cardiology
subject: 110323 Surgery
subject: FOS: Clinical medicine

description: Supplemental material, sj-pdf-1-vmj-10.1177_1358863X221148797 for Use of telemedicine facilitated by trained telepresenters to manage advanced peripheral artery disease in rural areas by Thomas J Breen, James B Peake, Heidi Keefe, Justine Moran, Felix Kunjukutty, Steven Pfau and S Elissa Altin in Vascular Medicine
sj-docx-1-cre-10.1177_02692155221150002 - Supplemental material for The influence of seated exercises on balance, mobility, and cardiometabolic health outcomes in individuals living with a stroke: A systematic review and meta-analysis
Creators: name: Mackie, Paul
name: Eng, Janice J
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 110314 Orthopaedics
subject: 110604 Sports Medicine
subject: FOS: Health sciences

description: Supplemental material, sj-docx-1-cre-10.1177_02692155221150002 for The influence of seated exercises on balance, mobility, and cardiometabolic health outcomes in individuals living with a stroke: A systematic review and meta-analysis by Paul Mackie and Janice J Eng in Clinical Rehabilitation
IL-6 Response to Psychosocial Stress Predicts 12-month Changes in Cardiometabolic Biomarkers in Perimenopausal Women
Creators: name: Girdler, Susan S
name: Rubinow, David R
name: Hinderliter, Alan L
name: Zannas, Anthony S
name: Gordon, Jennifer L
Publisher: name: The Endocrine Society
Year: 2020

description: OBJECTIVE: Cardiometabolic diseases are the number one cause of mortality, accounting for over one third of all deaths in the United States. Cardiometabolic risk further increases with psychosocial stress exposure and during menopausal transition in women. Because disease risk and stress burden are associated with aberrant immune signaling, we hypothesized that responses of interleukin-6 (IL-6) to psychosocial stress may predict longitudinal cardiometabolic outcomes in perimenopausal women. METHODS: We conducted post hoc analyses in 151 perimenopausal or early postmenopausal women participants in a previously completed study. At study onset, participants underwent the Trier Social Stress Test (TSST), and plasma IL-6 was measured repeatedly before and during the 1 hour post-TSST. Subsequently, participants were randomly assigned to either hormonal treatment (HT) or placebo and followed for 12 months to determine longitudinal changes in cardiometabolic biomarkers. RESULTS: Greater IL-6 reactivity to stress, measured with baseline-adjusted area under the curve, predicted 12-month decrease in flow-mediated dilatation of the brachial artery (P = 0.0005), a measure of endothelial-dependent vascular function, but not in endothelial-independent function measured with nitroglycerin-mediated dilatation (P = 0.17). Greater baseline IL-6 levels predicted 12-month increase in insulin resistance based on the homeostatic model assessment of insulin resistance score (P = 0.0045) and in the number of criteria met for metabolic syndrome (P = 0.0008). These predictions were not moderated by HT. CONCLUSIONS: Greater baseline IL-6 levels as well as its reactivity to stress may predict worsening in distinct cardiometabolic biomarkers as women transition to menopause. Interleukin-6 reactivity predicts decline in endothelial-dependent vascular function, whereas baseline IL-6 presages accumulation of metabolic risk.
sj-docx-1-dst-10.1177_19322968221149040 – Supplemental material for Estimation of a Machine Learning-Based Decision Rule to Reduce Hypoglycemia Among Older Adults With Type 1 Diabetes: A Post Hoc Analysis of Continuous Glucose Monitoring in the WISDM Study
Creators: name: Kahkoska, Anna R.
name: Shah, Kushal S.
name: Kosorok, Michael R.
name: Miller, Kellee M.
name: Rickels, Michael
name: Weinstock, Ruth S.
name: Young, Laura A.
name: Pratley, Richard E.
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 110306 Endocrinology
subject: FOS: Clinical medicine
subject: Medicine
subject: 111199 Nutrition and Dietetics not elsewhere classified

description: Supplemental material, sj-docx-1-dst-10.1177_19322968221149040 for Estimation of a Machine Learning-Based Decision Rule to Reduce Hypoglycemia Among Older Adults With Type 1 Diabetes: A Post Hoc Analysis of Continuous Glucose Monitoring in the WISDM Study by Anna R. Kahkoska, Kushal S. Shah, Michael R. Kosorok, Kellee M. Miller, Michael Rickels, Ruth S. Weinstock, Laura A. Young and Richard E. Pratley in Journal of Diabetes Science and Technology
A Bayesian functional approach to test models of life course epidemiology over continuous time
Creators: name: Harris, Kathleen Mullan
name: Bodelet, Julien
name: Shanahan, Michael
name: Imeri, Hira
name: Hofer, Scott
name: Potente, Cecilia
name: Blanc, Guillaume
name: Chumbley, Justin
name: Muniz-Terrera, Graciela
Publisher: name: Oxford University Press (OUP)
Year: 2024

description: BACKGROUND: Life course epidemiology examines associations between repeated measures of risk and health outcomes across different phases of life. Empirical research, however, is often based on discrete-time models that assume that sporadic measurement occasions fully capture underlying long-term continuous processes of risk. METHODS: We propose (i) the functional relevant life course model (fRLM), which treats repeated, discrete measures of risk as unobserved continuous processes, and (ii) a testing procedure to assign probabilities that the data correspond to conceptual models of life course epidemiology (critical period, sensitive period and accumulation models). The performance of the fRLM is evaluated with simulations, and the approach is illustrated with empirical applications relating body mass index (BMI) to mRNA-seq signatures of chronic kidney disease, inflammation and breast cancer RESULTS: Simulations reveal that fRLM identifies the correct life course model with three to five repeated assessments of risk and 400 subjects. The empirical examples reveal that chronic kidney disease reflects a critical period process and inflammation and breast cancer likely reflect sensitive period mechanisms. CONCLUSIONS: The proposed fRLM treats repeated measures of risk as continuous processes and, under realistic data scenarios, the method provides accurate probabilities that the data correspond to commonly studied models of life course epidemiology. fRLM is implemented with publicly-available software.
sj-docx-1-jop-10.1177_02698811221144636 – Supplemental material for Role of serotonin in modulation of decision-making in Parkinson’s disease
Creators: name: Nobis, Lisa
name: Maio, Maria Raquel
name: Saleh, Youssuf
name: Manohar, Sanjay
name: Kienast, Annika
name: McGann, Emily
name: Husain, Masud
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 110904 Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: 170199 Psychology not elsewhere classified
subject: FOS: Psychology
subject: 110319 Psychiatry (incl. Psychotherapy)

description: Supplemental material, sj-docx-1-jop-10.1177_02698811221144636 for Role of serotonin in modulation of decision-making in Parkinson’s disease by Lisa Nobis, Maria Raquel Maio, Youssuf Saleh, Sanjay Manohar, Annika Kienast, Emily McGann and Masud Husain in Journal of Psychopharmacology
88309: The Pudding
Creators: name: Project Team, First World War Poetry Digital Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Part of a Typescript of 'The Patchwork Flag', which included 38 examples of war and children's verses, with Robert Graves' manuscript corrections. Compiled with Nancy Nicholson. Sent also to Edward Marsh. Contains one two-sided leaf of a manuscript comments by Siegfried Sassoon, dated 21st August (1918)" Not published after Graves received criticism both from Sassoon And Robert Ross.
Eutrophication, biodiversity loss, and species invasions modify the relationship between host and parasite richness during host community assembly
Creators: name: Wilfahrt, Peter A.
name: Heckman, Robert W.
name: Halliday, Fletcher W.
name: Mitchell, Charles E.
Publisher: name: Wiley
Year: 2020

description: Host and parasite richness are generally positively correlated, but the stability of this relationship in response to global change remains poorly understood. Rapidly changing biotic and abiotic conditions can alter host community assembly, which in turn, can alter parasite transmission. Consequently, if the relationship between host and parasite richness is sensitive to parasite transmission, then changes in host composition under various global change scenarios could strengthen or weaken the relationship between host and parasite richness. To test the hypothesis that host community assembly can alter the relationship between host and parasite richness in response to global change, we experimentally crossed host diversity (biodiversity loss) and resource supply to hosts (eutrophication), then allowed communities to assemble. As previously shown, initial host diversity and resource supply determined the trajectory of host community assembly, altering post-assembly host species richness, richness-independent host phylogenetic diversity, and colonization by exotic host species. Overall, host richness predicted parasite richness, and as predicted, this effect was moderated by exotic abundance-communities dominated by exotic species exhibited a stronger positive relationship between post-assembly host and parasite richness. Ultimately, these results suggest that, by modulating parasite transmission, community assembly can modify the relationship between host and parasite richness. These results thus provide a novel mechanism to explain how global environmental change can generate contingencies in a fundamental ecological relationship-the positive relationship between host and parasite richness.
Swimming downstream: statistical analysis of differential transcript usage following Salmon quantification
Creators: name: Patro, Rob
name: Soneson, Charlotte
name: Love, Michael I.
Publisher: name: F1000Research
Year: 2018

description: Detection of differential transcript usage (DTU) from RNA-seq data is an important bioinformatic analysis that complements differential gene expression analysis. Here we present a simple workflow using a set of existing R/Bioconductor packages for analysis of DTU. We show how these packages can be used downstream of RNA-seq quantification using the Salmon software package. The entire pipeline is fast, benefiting from inference steps by Salmon to quantify expression at the transcript level. The workflow includes live, runnable code chunks for analysis using DRIMSeq and DEXSeq, as well as for performing two-stage testing of DTU using the stageR package, a statistical framework to screen at the gene level and then confirm which transcripts within the significant genes show evidence of DTU. We evaluate these packages and other related packages on a simulated dataset with parameters estimated from real data.
The Profile Analysis Of Job Satisfaction - Reliability, Validity And Benefits Of A New Measurement
Creators: name: Jiménez, Paulino
Publisher: name: Zenodo
Year: 2003
Subjects: job satisfaction
turnover
intention to quit
measurement development
model of job satisfaction
cybernetics
absenteeism

description: Job satisfaction is important for companies. Nevertheless it is often measured with global or single items. The results therefore are sometimes disappointing, leading to the conclusion that measuring job satisfaction doesn’t bring useful information. The cybernetic model of job satisfaction (Jiménez, 2000) takes a new approach: Job satisfaction is seen as a comparison of a reference value with an actual situation, the resulting action is seen as feedback. The results also generate expectations regarding future possibilities – the level of comparison is being changed. These comparisons are made for several dimensions. The Profile Analysis of Job Satisfaction (PAJS, Jiménez, 2000) takes these assumptions into account and therefore has 11 different scales. Various empirical studies are presented which underline the high validity and reliability of this instrument. PAJS is a statistically well proven instrument that can be used for a broad circle of clients and which measures job satisfaction in a very differentiating form. The construction, the psychometric quality and its possibilities of application as a screening instrument but also for usage in balanced score cards is shown. The results for the Profile Analysis of Job Satisfaction show very good predictive value for important aspects like intention to quit, burnout, withdrawal, motivation. Because of its economical core it can be filled out in a short time. It can also be expanded through additional company-specific questions. This approach helps companies to act in advance to raise motivation at work. The application for scientific and practical approaches is discussed.
Computationally-guided drug repurposing enables the discovery of kinase targets and inhibitors as new schistosomicidal agents
Creators: name: Silva, Arthur C.
name: Muratov, Eugene N.
name: Ramos, Pablo I. P.
name: Furnham, Nicholas
name: Borba, Joyce V. V. B.
name: Andrade, Carolina Horta
name: Giuliani, Sandra
name: Paveley, Ross A.
Publisher: name: Public Library of Science (PLoS)
Year: 2018

description: The development of novel therapeutics is urgently required for diseases where existing treatments are failing due to the emergence of resistance. This is particularly pertinent for parasitic infections of the tropics and sub-tropics, referred to collectively as neglected tropical diseases, where the commercial incentives to develop new drugs are weak. One such disease is schistosomiasis, a highly prevalent acute and chronic condition caused by a parasitic helminth infection, with three species of the genus Schistosoma infecting humans. Currently, a single 40-year old drug, praziquantel, is available to treat all infective species, but its use in mass drug administration is leading to signs of drug-resistance emerging. To meet the challenge of developing new therapeutics against this disease, we developed an innovative computational drug repurposing pipeline supported by phenotypic screening. The approach highlighted several protein kinases as interesting new biological targets for schistosomiasis as they play an essential role in many parasite's biological processes. Focusing on this target class, we also report the first elucidation of the kinome of Schistosoma japonicum, as well as updated kinomes of S. mansoni and S. haematobium. In comparison with the human kinome, we explored these kinomes to identify potential targets of existing inhibitors which are unique to Schistosoma species, allowing us to identify novel targets and suggest approved drugs that might inhibit them. These include previously suggested schistosomicidal agents such as bosutinib, dasatinib, and imatinib as well as new inhibitors such as vandetanib, saracatinib, tideglusib, alvocidib, dinaciclib, and 22 newly identified targets such as CHK1, CDC2, WEE, PAKA, MEK1. Additionally, the primary and secondary targets in Schistosoma of those approved drugs are also suggested, allowing for the development of novel therapeutics against this important yet neglected disease.
Deep reinforcement learning with positional context for intraday trading
Creators: name: Goluža, Sven
name: Kovačević, Tomislav
name: Bauman, Tessa
name: Kostanjčar, Zvonko
Publisher: name: arXiv
Year: 2024
Subjects: subject: Trading and Market Microstructure (q-fin.TR)
subject: FOS: Economics and business

description: Deep reinforcement learning (DRL) is a well-suited approach to financial decision-making, where an agent makes decisions based on its trading strategy developed from market observations. Existing DRL intraday trading strategies mainly use price-based features to construct the state space. They neglect the contextual information related to the position of the strategy, which is an important aspect given the sequential nature of intraday trading. In this study, we propose a novel DRL model for intraday trading that introduces positional features encapsulating the contextual information into its sparse state space. The model is evaluated over an extended period of almost a decade and across various assets including commodities and foreign exchange securities, taking transaction costs into account. The results show a notable performance in terms of profitability and risk-adjusted metrics. The feature importance results show that each feature incorporating contextual information contributes to the overall performance of the model. Additionally, through an exploration of the agent's intraday trading activity, we unveil patterns that substantiate the effectiveness of our proposed model.
sj-docx-4-jop-10.1177_02698811221147152 – Supplemental material for Reduction in caffeine withdrawal after open-label decaffeinated coffee
Creators: name: Mills, Llewellyn
name: Lee, Jessica C.
name: Boakes, Robert
name: Colagiuri, Ben
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: Psychology not elsewhere classified
subject: Psychiatry (incl. Psychotherapy)

description: Supplemental material, sj-docx-4-jop-10.1177_02698811221147152 for Reduction in caffeine withdrawal after open-label decaffeinated coffee by Llewellyn Mills, Jessica C. Lee, Robert Boakes and Ben Colagiuri in Journal of Psychopharmacology
Failed Target Weight Achievement Associates with Short-Term Hospital Encounters among Individuals Receiving Maintenance Hemodialysis
Creators: name: Assimon, Magdalene M
name: Wang, Lily
name: Flythe, Jennifer E
Publisher: name: Wolters Kluwer
Year: 2018

description: Background Hospitalizations and 30-day readmissions are common in the hemodialysis population. Actionable clinical markers for near-term hospital encounters are needed to identify individuals who require swift intervention to avoid hospitalization. Aspects of volume management, such as failed target weight (i.e, estimated dry weight) achievement, are plausible modifiable indicators of impending adverse events. The short-term consequences of failed target weight achievement are not well established.Methods Statistically deidentified data were taken from a cohort of Medicare-enrolled, prevalent hemodialysis patients treated at a large dialysis organization from 2010 to 2012. We used a retrospective cohort design with repeated intervals, each consisting of 180-day baseline, 30-day exposure assessment, and 30-day follow-up period, to estimate the associations between failed target weight achievement and the risk of 30-day emergency department visits and hospitalizations. We estimated adjusted risk differences using inverse probability of exposure weighted Kaplan-Meier methods.Results A total of 113,561 patients on hemodialysis contributed 788,722 study intervals to analyses. Patients who had a postdialysis weight >1.0 kg above the prescribed target weight in ≥30% (versus <30%) of exposure period treatments had a higher absolute risk (risk difference) of 30-day: emergency department visits (2.13%; 95% confidence interval, 2.00% to 2.32%); and all-cause (1.47%; 95% confidence interval, 1.34% to 1.62%), cardiovascular (0.31%; 95% confidence interval, 0.24% to 0.40%), and volume-related (0.15%; 95% confidence interval, 0.11% to 0.21%) hospitalizations.Conclusions In the absence of objective measures of volume status, recurrent failure to achieve target weight is an easily identifiable clinical risk marker for impending hospital encounters among patients on hemodialysis.
sj-docx-8-jop-10.1177_02698811221147152 – Supplemental material for Reduction in caffeine withdrawal after open-label decaffeinated coffee
Creators: name: Mills, Llewellyn
name: Lee, Jessica C.
name: Boakes, Robert
name: Colagiuri, Ben
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: Psychology not elsewhere classified
subject: Psychiatry (incl. Psychotherapy)

description: Supplemental material, sj-docx-8-jop-10.1177_02698811221147152 for Reduction in caffeine withdrawal after open-label decaffeinated coffee by Llewellyn Mills, Jessica C. Lee, Robert Boakes and Ben Colagiuri in Journal of Psychopharmacology
Insurance instability and use of emergency and office-based care after gaining coverage: An observational cohort study
Creators: name: Platts-Mills, Timothy F.
name: Trogdon, Justin G.
name: Sabik, Lindsay M.
name: Shafer, Paul R.
name: Stearns, Sally C.
name: Dusetzina, Stacie B.
Publisher: name: Public Library of Science (PLoS)
Year: 2020

description: BACKGROUND: The Affordable Care Act led to improvements in reporting a usual source of care, but it is unclear whether patients are changing their usual source of care in response to coverage gains. We assess whether prior insurance instability is associated with changes in use of emergency and office-based care after the Marketplace and Medicaid expansion were introduced. METHODS: Our study draws from the 2013-14 Medical Expenditure Panel Survey, identifying a cohort of non-elderly adults with full-year health insurance coverage in 2014. We use linear and multinomial logistic regression to assess the relationship between insurance instability prior to 2014 (uninsured for 1-11 months, ≥12 months) and person-level changes in use of health care after gaining coverage (change in ED and office visits from 2013 to 2014) with continuously insured individuals serving as a comparison group. RESULTS: Being uninsured for at least one year prior to gaining full-year coverage in 2014 was associated with a 33% increase in ED visits (0.06 visits, p<0.01) and a 47% increase in office visits (1.10 visits, p<0.01), driven by those gaining public coverage. We found no evidence of substitution across settings in the short term, often a stated goal of expansion. CONCLUSION: The long-term uninsured may have substantial health needs and pent-up demand for health care, seeing more physicians across multiple settings in the year after gaining coverage as they seek to get unmanaged conditions under control. Closing the gap in primary care use between the previously uninsured and those with health insurance coverage may help improve long-term health outcomes.
Chalcones as a basis for computer-aided drug design: innovative approaches to tackle malaria
Creators: name: Muratov, Eugene N
name: Cassiano, Gustavo C
name: Costa, Fabio TM
name: Ferreira, Leticia T
name: Bargieri, Daniel Y
name: Neves, Bruno J
name: Tomaz, Kaira CP
name: Lima, Marilia NN
name: Gomes, Marcelo N
name: Andrade, Carolina Horta
name: Calit, Juliana
name: Tavella, Tatyana A
Publisher: name: Taylor & Francis
Year: 2019

description: Aim: Computer-aided drug design approaches were applied to identify chalcones with antiplasmodial activity. Methodology: The virtual screening was performed as follows: structural standardization of in-house database of chalcones; identification of potential Plasmodium falciparum protein targets for the chalcones; homology modeling of the predicted P. falciparum targets; molecular docking studies; and in vitro experimental validation. Results: Using these models, we prioritized 16 chalcones with potential antiplasmodial activity, for further experimental evaluation. Among them, LabMol-86 and LabMol-87 showed potent in vitro antiplasmodial activity against P. falciparum, while LabMol-63 and LabMol-73 were potent inhibitors of Plasmodium berghei progression into mosquito stages. Conclusion: Our results encourage the exploration of chalcones in hit-to-lead optimization studies for tackling malaria.
sj-pdf-2-imr-10.1177_03000605221147444 - Supplemental material for Screening and verification of genes related to polycystic ovary syndrome
Creators: name: Li, Xuebing
name: Wang, Chunxia
name: Yang, Heng
name: Pei, Dongxu
name: Liu, Yuchun
name: Yan, Sha
name: Li, Yongwei
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: Health and Community Services
subject: Cardiology
subject: Dentistry not elsewhere classified
subject: Emergency Medicine
subject: Endocrinology
subject: Geriatrics and Gerontology
subject: Neurology and Neuromuscular Diseases
subject: FOS: Clinical medicine
subject: Nursing not elsewhere classified
subject: Nutrition and Dietetics not elsewhere classified
subject: Oncology and Carcinogenesis not elsewhere classified
subject: Orthopaedics
subject: Sports Medicine
subject: Otorhinolaryngology
subject: Aged Health Care
subject: Paediatrics
subject: Pharmacology and Pharmaceutical Sciences not elsewhere classified
subject: Psychology not elsewhere classified
subject: Psychiatry (incl. Psychotherapy)
subject: Public Health and Health Services not elsewhere classified
subject: Respiratory Diseases
subject: Sociological Methodology and Research Methods
subject: Surgery

description: Supplemental material, sj-pdf-2-imr-10.1177_03000605221147444 for Screening and verification of genes related to polycystic ovary syndrome by Xuebing Li, Chunxia Wang, Heng Yang, Dongxu Pei, Yuchun Liu, Sha Yan and Yongwei Li in Journal of International Medical Research
A Nexus Model of Restricted Interests in Autism Spectrum Disorder
Creators: name: Jung, Heejung
name: Blakeley-Smith, Audrey
name: Carter, R. McKell
name: Reaven, Judy
name: Dichter, Gabriel S.
Publisher: name: Frontiers
Year: 2020

description: Restricted interests (RIs) in autism spectrum disorder (ASD) are clinically impairing interests of unusual focus or intensity. They are a subtype of restricted and repetitive behaviors which are one of two diagnostic criteria for the disorder. Despite the near ubiquity of RIs in ASD, the neural basis for their development is not well understood. However, recent cognitive neuroscience findings from nonclinical samples and from individuals with ASD shed light on neural mechanisms that may explain the emergence of RIs. We propose the nexus model of RIs in ASD, a novel conceptualization of this symptom domain that suggests that RIs may reflect a co-opting of brain systems that typically serve to integrate complex attention, memory, semantic, and social communication functions during development. The nexus model of RIs hypothesizes that when social communicative development is compromised, brain functions typically located within the lateral surface of cortex may expand into social processing brain systems and alter cortical representations of various cognitive functions during development. These changes, in turn, promote the development of RIs as an alternative process mediated by these brain networks. The nexus model of RIs makes testable predictions about reciprocal relations between the impaired development of social communication and the emergence of RIs in ASD and suggests novel avenues for treatment development.
sj-docx-1-smm-10.1177_09622802221146305 - Supplemental material for Taking a chance: How likely am I to receive my preferred treatment in a clinical trial?
Creators: name: Walter, Stephen D
name: Blaha, Ondrej
name: Esserman, Denise
Publisher: name: SAGE Journals
Year: 2023
Subjects: subject: 111708 Health and Community Services
subject: FOS: Health sciences
subject: 111099 Nursing not elsewhere classified
subject: 160807 Sociological Methodology and Research Methods
subject: FOS: Sociology

description: Supplemental material, sj-docx-1-smm-10.1177_09622802221146305 for Taking a chance: How likely am I to receive my preferred treatment in a clinical trial? by Stephen D Walter, Ondrej Blaha and Denise Esserman in Statistical Methods in Medical Research
title: Lavandula, Lavender :
title: Guidelines for the Conduct of Tests for Distinctness, Uniformity and Stability.
titleType: Subtitle
Creators: name: International Union For The Protection Of New Varieties Of Plants,
Publisher: name: International Union for the Protection of New Varieties of Plants,
Year: 0
Subjects: New Varieties of Plants
Lavender

description: The purpose of these guidelines (“Test Guidelines”) is to elaborate the principles contained in the General Introduction (document TG/1/3), and its associated TGP documents, into detailed practical guidance for the harmonized examination of distinctness, uniformity and stability (DUS) and, in particular, to identify appropriate characteristics for the examination of DUS and production of harmonized variety descriptions.
Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization
Creators: name: Lerch, Jason P.
name: Gozzi, Alessandro
name: Dijkhuizen, Rick M.
name: Grandjean, Joanes
name: Chakravarty, M. Mallar
name: Garin, Clement M.
name: Hess, Andreas
name: Cerri, Domenic H.
name: Mandino, Francesca
name: Dhenain, Marc
name: Straathof, Milou
name: Keilholz, Shella D.
name: van Tilborg, Geralda A. F.
name: Shih, Yen-Yu Ian
Publisher: name: Frontiers
Year: 2020

description: Animal whole-brain functional magnetic resonance imaging (fMRI) provides a non-invasive window into brain activity. A collection of associated methods aims to replicate observations made in humans and to identify the mechanisms underlying the distributed neuronal activity in the healthy and disordered brain. Animal fMRI studies have developed rapidly over the past years, fueled by the development of resting-state fMRI connectivity and genetically encoded neuromodulatory tools. Yet, comparisons between sites remain hampered by lack of standardization. Recently, we highlighted that mouse resting-state functional connectivity converges across centers, although large discrepancies in sensitivity and specificity remained. Here, we explore past and present trends within the animal fMRI community and highlight critical aspects in study design, data acquisition, and post-processing operations, that may affect the results and influence the comparability between studies. We also suggest practices aimed to promote the adoption of standards within the community and improve between-lab reproducibility. The implementation of standardized animal neuroimaging protocols will facilitate animal population imaging efforts as well as meta-analysis and replication studies, the gold standards in evidence-based science.
Additional file 3 of Effects of pulmonary air leak on patients with coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis
Creators: name: Zhong, Zhuan
name: Guo, Jia
name: Li, Xingzhao
name: Han, Yingying
Publisher: name: figshare
Year: 2024
Subjects: Medicine
Biotechnology
Biological Sciences not elsewhere classified
Science Policy

description: Supplementary Material 3
Automatic Skull Stripping of Rat and Mouse Brain MRI Data Using U-Net
Creators: name: Ban, Woomi
name: Lee, Sung-Ho
name: Hsu, Li-Ming
name: Song, Sheng
name: Shih, Yen-Yu Ian
name: Broadwater, Margaret A.
name: Shen, Dinggang
name: Ranadive, Paridhi
name: Wang, Shuai
name: Walton, Lindsay R.
name: Cerri, Domenic Hayden
name: Chao, Tzu-Hao Harry
Publisher: name: Frontiers
Year: 2020

description: Accurate removal of magnetic resonance imaging (MRI) signal outside the brain, a.k.a., skull stripping, is a key step in the brain image pre-processing pipelines. In rodents, this is mostly achieved by manually editing a brain mask, which is time-consuming and operator dependent. Automating this step is particularly challenging in rodents as compared to humans, because of differences in brain/scalp tissue geometry, image resolution with respect to brain-scalp distance, and tissue contrast around the skull. In this study, we proposed a deep-learning-based framework, U-Net, to automatically identify the rodent brain boundaries in MR images. The U-Net method is robust against inter-subject variability and eliminates operator dependence. To benchmark the efficiency of this method, we trained and validated our model using both in-house collected and publicly available datasets. In comparison to current state-of-the-art methods, our approach achieved superior averaged Dice similarity coefficient to ground truth T2-weighted rapid acquisition with relaxation enhancement and T2*-weighted echo planar imaging data in both rats and mice (all p < 0.05), demonstrating robust performance of our approach across various MRI protocols.
sj-docx-1-evb-10.1177_11769343221142013 – Supplemental material for The Prognostic Value of a lncRNA Risk Model Consists of 9 m6A Regulator-Related lncRNAs in Hepatocellular Carcinoma (HCC)
Creators: name: Deng, Zhen
name: Hou, Jiaxing
name: Xu, Hongbo
name: Lei, Zhao
name: Li, Zhiqiang
name: Zhu, Hongwei
name: Yu, Xiao
name: Yang, Zhi
name: Jin, Xiaoxin
name: Sun, Jichun
Publisher: name: SAGE Journals
Year: 2023
Subjects: Cell Biology

description: Supplemental material, sj-docx-1-evb-10.1177_11769343221142013 for The Prognostic Value of a lncRNA Risk Model Consists of 9 m6A Regulator-Related lncRNAs in Hepatocellular Carcinoma (HCC) by Zhen Deng, Jiaxing Hou, Hongbo Xu, Zhao Lei, Zhiqiang Li, Hongwei Zhu, Xiao Yu, Zhi Yang, Xiaoxin Jin and Jichun Sun in Evolutionary Bioinformatics
88211: Here They Lie
Creators: name: Project Team, First World War Poetry Digital Archive
Publisher: name: University of Oxford
Year: 2024
Subjects: classificationCode: 430304
subject: British history
classificationCode: 430308
subject: European history (excl. British, classical Greek and Roman)
classificationCode: 430316
subject: International history

description: Part of a Typescript of 'The Patchwork Flag', which included 38 examples of war and children's verses, with Robert Graves' manuscript corrections. Compiled with Nancy Nicholson. Sent also to Edward Marsh. Contains one two-sided leaf of a manuscript comments by Siegfried Sassoon, dated 21st August (1918)" Not published after Graves received criticism both from Sassoon And Robert Ross.