cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
DIAGNOSTIC AND THERAPEUTIC MANAGEMENT OF IATROGENIC LESIONS OF LINGUAL AND INFERIOR ALVEOLAR NERVE
Creators: name: ALLEVI, FABIANA
Publisher: name: Universit� degli Studi di Milano
Year: 2019

description: Trigeminal nerve branches injuries are more and more frequent because of the wide spread of oral surgery. When the nerve damage involves the lingual nerve (LN) or the inferior alveolar nerve (IAN), the negative impact of the nervous dysfunction on the daily life of patients is relevant. Patients usually describe their condition as a crippling disease interfering with their common daily activities (talking, eating and drinking) and, consequently, forcing them to give up their social life. This difficult situation is undoubtedly worse when pain is present. It is about a neuropathic pain due to the nerve damage and the wrong regeneration process that make a mixture of nervous fibres and scar tissue. It is a dull pain described by one of our patient as ?a monster that never gives up, always present as a new life-mate?. Moreover, all these feelings and patients? adaptability have always to be correlate to the kind of surgery that caused the symptoms themselves. It?s not easy to understand and accept a complete lingual anaesthesia associated with continuous pain appeared after the removal of an asymptomatic wisdom molar! The same symptoms appeared after the removal of a malign tumour are usually more acceptable. Unfortunately, even today, there is no worldwide consensus about how to early recognize and eventually treat this kind of lesions. Nowadays, these iatrogenic nerve damages culminate more and more frequent in legal matters. A standardization of diagnostic and therapeutic management is necessary, to clarify which the correct approach for each patient is. This project aimed to standardize through the founding of a specific Clinic the management of patients affected by lingual nerve and inferior alveolar nerve lesion, in order to propose a common diagnostic process, followed by both the patient-specific reconstructive surgery and the regular clinic and neurophysiological follow up. The standardized management allows to understand the actual efficacy of this kind of surgery.
What is the evidence base for care models within care homes that improve the end of life for patients and their carers? A rapid review
Creators: name: Chatland, Laura
name: Mann, Mala
name: Byrne, Anthony
name: Best, Sabine
Publisher: name: AMRC Open Research
Year: 2020

description: Care homes are a common place of residence for older people who are nearing the end of their lives. Often those living in care or residential homes have multiple long-term conditions and palliative care needs and this can lead to poorer quality of life, quality of death and unnecessary hospital admissions. There is anecdotal evidence from service evaluations that suggest there are benefits of implementing interventions within care homes for people at the end of life and their families/ carers (Garden et al. 2016; Finucance et al. 2013). This rapid review aims to identify robust evidence for interventions/care models within care homes which improve quality of life and quality of care outcomes within the UK or comparable countries.
Assessing preferences for rural landscapes: An attribute based choice modelling approach
Creators: name: Ryan, Mary
name: O'Donoghue, Cathal
name: Hynes, Stephen
name: Kilgarriff, Paul
name: Tsakiridis, Andreas
Publisher: name: Bio-based and Applied Economics
Year: 2020

description: This study adopts a choice modelling framework to disentangle individual preferences for rural landscape attributes based on the viewing of photographs of the Irish countryside. Using ordered logit and standard panel and pooled regression models, societal preferences are quantified for rural landscape attributes, grouped into natural, agricultural and human-built non-agricultural categories. The preferences of 430 individuals towards 50 rural landscape photographs are analysed. The results show positive preferences for landscapes with natural attributes such as cliffs, mountainous features, water and native trees, as well as preferences for neat/managed agricultural landscapes and traditional human-built features such as stone walls and planted hedgerows. The study shows negative preferences for features such as flooding, unmanaged landscapes, industrial turf cutting and mechanised features such as wind turbines. There is significant preference heterogeneity observed across the sample particularity across the urban-rural residency divide. It is argued that analysing preferences for specific attributes of landscapes rather than preferences for individual landscape photographs allows for further applications particularly in the area of simulation.
description: Bio-based and Applied Economics, Vol. 9 No. 2 (2020): Economics of culture and food in evolving agri-food systems and rural areas
Exploring governance mechanisms, collaborative processes and main challenges in short food supply chains: the case of Turkey
Creators: name: Kurtsal, Yaprak
name: Karakaya Ayalp, Emel
name: Viaggi, Davide
Publisher: name: Bio-based and Applied Economics
Year: 2020

description: There is a growing scientific interest and public debate on the potential contributions that Local Food Systems (LFS) and Short Food Supply Chains (SFSCs) can make towards overcoming sustainability challenges and creating societal impact. In the case of Turkey, where local agricultural systems are particularly vulnerable, lacking of resilience and innovative capacity, understanding the governance mechanisms of SFSCs would have strong implications for policy making. To this end, our aim in this study is to explore the mechanisms through which civil society driven SFSCs are governed in the city of Izmir (Turkey), referring to the actors involved in the process, institutional frameworks that are adopted and challenges experienced, that could inform policy discussions towards establishing more sustainable local food systems. In this direction, the questions we aim to answer are: (1) what are the mechanisms through which community level SFSCs are initiated and governed, (2) how collaboration takes place within these groups and through which processes, and finally (3) what the outcomes of these processes are, with respect to individual, community and local impacts experienced on the ground, and challenges associated with them. We use a descriptive case study methodology, to study seven SFSC initiatives (four food community networks, two farmers’ markets and a local shop) in the city of Izmir; and collect data through qualitative semi-structured in-depth interviews (41 with producers, 32 with consumers, 11 with coordinators and 5 with experts). Our findings suggest that different mechanisms are at play within our cases, depending on aspects including their governing structures and their way and purpose of operation. While farmers had difficulties relying solely on their income from these initiatives for their livelihoods, organizational challenges experienced by food communities were mainly related to difficulties associated to managing tasks on a voluntary basis. Moreover, arriving at a shared understanding about mutual goals, in addition to finding a way to include stakeholders in the process, were among the most prevalent challenges of all initiatives.
description: Bio-based and Applied Economics, Vol. 9 No. 2 (2020): Economics of culture and food in evolving agri-food systems and rural areas
Additional file 3 of Ovarian activation delays in peripubertal ewe lambs infected with Haemonchus contortus can be avoided by supplementing protein in their diets
Creators: name: Suarez-Henriques, Paula
name: de Miranda e Silva Chaves, Camila
name: Cardoso-Leite, Ricardo
name: Gomes-Caldas, Danielle G.
name: Morita-Katiki, Luciana
name: Tsai, Siu Mui
name: Louvandini, Helder
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: Additional file 3: Table S3. Percentage of mapping to gene regions.
OBSERVING THE POLARIZED COSMIC MICROWAVE BACKGROUND FROM THE EARTH: SCANNING STRATEGY AND POLARIMETERS TEST FOR THE LSPE/STRIP INSTRUMENT
Creators: name: INCARDONA, FEDERICO
Publisher: name: Universit� degli Studi di Milano
Year: 2020

description: Detecting B-mode polarization anisotropies on large angular scales in the Cosmic Microwave Background (CMB) polarization pattern is one of the major challenges in modern observational cosmology since it would give us an important evidence in favor of the inflationary paradigm and would shed light on the physics of the very early Universe. Multi-frequency observations are required to disentangle the very weak CMB signal from diffuse polarized foregrounds originating by radiative processes in our galaxy. The ?Large Scale Polarization Explorer? (LSPE) is an experiment that aims to constrain the ratio between the amplitudes of tensor and scalar modes to r ? 0.03 and to study the polarized emission of the Milky Way. LSPE is composed of two instruments: SWIPE, a stratospheric balloon operating at 140, 210 and 240 GHz that will fly for two weeks in the Northern Hemisphere during the polar night of 2021, and STRIP, a ground-based telescope that will start to take data in early 2021 from the ?Observatorio del Teide? in Tenerife observing the sky at 43 GHz (Q-band) and 95 GHz (W-band). In my thesis, I show the results of the unit-level tests campaign on the STRIP detectors that took place at ?Universit� degli Studi di Milano Bicocca? from September 2017 to July 2018, and I present the code I developed and the simulations I performed to study the STRIP scanning strategy. During the unit-level tests, more than 800 tests on 68 polarimeters have been performed in order to select the 55 (49 Q-band and 6 W-band) with the best performance in terms of central frequencies, bandwidths, noise temperatures, white noise levels, slopes and knee frequencies. The STRIP scanning strategy is based on spinning the telescope around the azimuth axis with constant elevation in order to overlap the SWIPE coverage maintaining a sensitivity of 1.6 �K (on average) per sky pixels of 1�. Individual sources will be periodically observed both for calibration and study purposes.
Additional file 2 of Ovarian activation delays in peripubertal ewe lambs infected with Haemonchus contortus can be avoided by supplementing protein in their diets
Creators: name: Suarez-Henriques, Paula
name: de Miranda e Silva Chaves, Camila
name: Cardoso-Leite, Ricardo
name: Gomes-Caldas, Danielle G.
name: Morita-Katiki, Luciana
name: Tsai, Siu Mui
name: Louvandini, Helder
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: Additional file 2: Table S2. Number of sequences and Sequencing depth generated by RNA sequencing.
Thermodynamics of histories for the one-dimensional contact process
Creators: name: Hooyberghs, Jef
name: Vanderzande, Carlo
Publisher: name: arXiv
Year: 2009
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: FOS: Physical sciences

description: The dynamical activity K(t) of a stochastic process is the number of times it changes configuration up to time t. It was recently argued that (spin) glasses are at a first order dynamical transition where histories of low and high activity coexist. We study this transition in the one-dimensional contact process by weighting its histories by exp(sK(t)). We determine the phase diagram and the critical exponents of this model using a recently developed approach to the thermodynamics of histories that is based on the density matrix renormalisation group. We find that for every value of the infection rate, there is a phase transition at a critical value of s. Near the absorbing state phase transition of the contact process, the generating function of the activity shows a scaling behavior similar to that of the free energy in an equilibrium system near criticality.
description: 16 pages, 7 figures
An abstract Nyquist criterion containing old and new results
Creators: name: Sasane, Amol
Publisher: name: arXiv
Year: 2010
Subjects: subject: Optimization and Control (math.OC)
subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 93D15, 46J20

description: We prove an abstract Nyquist criterion in a general set up. As applications, we recover various versions of the Nyquist criterion, some of which are new.
description: 19 pages
Step-by-step development of a model simulating returns on farm from investments: the example of hazelnut plantation in Italy
Creators: name: Spiegel, Alisa
name: Severini, Simone
name: Britz, Wolfgang
name: Coletta, Attilio
Publisher: name: Bio-based and Applied Economics
Year: 2020

description: Recent literature reviews of empirical models optimizing long-term investments in agriculture see gaps with regard to (i) separating investment and financing decisions, (ii) considering explicitly risk and temporal flexibility, and (iii) accounting for farm-level resource endowments and other constraints. Inspired by real options approaches, this paper therefore stepwise develops a model extending a simple net present value calculation to a farm-scale simulation model based on mathematical programming, which considers time flexibility, different financing options and downside risk aversion. We empirically assess the different model variants by analysing investments into hazelnut orchards in Italy outside of traditional producing regions. The variants suggest quite different optimal results with respect to scale and timing of the investment, its financing and the expected NPV. The stepwise approach reveals which aspects drive these differences and underlines that considering temporal flexibility, different financing options and riskiness can considerably improve traditional NPV analysis.
description: Bio-based and Applied Economics, Vol. 9 No. 1 (2020)
DIAGNOSTICS OF PARTIALLY COHERENT RADIATION FROM ULTRARELATIVISTIC BEAMS: THE HETERODYNE NEAR FIELD SPECKLE APPROACH
Creators: name: SIANO, MIRKO
Publisher: name: Universit� degli Studi di Milano
Year: 2017

description: X-ray radiation from relativistic charged particle beams has nowadays achieved unprecedented high brilliance and high degree of coherence, fostering the development of coherence-based techniques such as coherent diffractive imaging, photon correlation spectroscopy and phase contrast imaging. Probing the spatial and temporal coherence properties of the X-ray beam is of outermost importance for proper planning of the experiments and for unbiased data reduction. It also paves the way to non-invasive diagnostics techniques aimed at gauging the transverse emittance of the particle beam. Consequently, coherence diagnostics of the radiation emitted in third- and fourth-generation light sources represents an increasingly challenging demand. In this thesis we describe a novel coherence diagnostics technique named Heterodyne Near Field Speckle (HNFS). It exploits the staggering self-referenced interference between the weak spherical waves scattered by nanoparticles in a colloidal suspension and the strong transmitted field to probe the coherence properties of the radiation by means of Fourier analysis of the resulting stochastic speckle fields. A criterion based on master curves from data acquired at different sample-detector distances is introduced, allowing to gauge spatial and temporal coherence separately by means of two different scaling laws. The technique requires a minimal setup and it is ultimately wavelength independent. It can be operated also at X-ray wavelengths, remarkably without any dedicated optics. We first show results obtained with visible table-top thermal sources, validating the master curve criterion and introducing the concept of Analogical Optical Modeling. Then we provide a characterization of the spatio-temporal coherence properties of a pulsed High Harmonic Generation laser at the ELETTRA synchrotron (Trieste, Italy). Finally, the technique is applied to measure the coherence properties of visible synchrotron radiation and of soft X-ray undulator radiation at the ALBA facility (Barcelona, Spain), showing how the technique can be effectively implemented as a valuable beam diagnostics tool.
Wellposedness of Cauchy problem for the Fourth Order Nonlinear Schrödinger Equations in Multi-dimensional Spaces
Creators: name: Hao, Chengchun
name: Hsiao, Ling
name: Wang, Baoxiang
Publisher: name: arXiv
Year: 2008
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35Q55;35G25;35A07

description: We study the wellposedness of Cauchy problem for the fourth order nonlinear Schrödinger equations i\partial_t u=-\epsΔu+Δ^2 u+P((\partial_x^αu)_{\absα\ls 2}, (\partial_x^α\bar{u})_{\absα\ls 2}),\quad t\in \Real, x\in\Real^n, where $\eps\in\{-1,0,1\}$, $n\gs 2$ denotes the spatial dimension and $P(\cdot)$ is a polynomial excluding constant and linear terms.
description: 28 pages
Additional file 1 of Bridging mapping and simulation modelling in the ecosystem service assessments of boreal forests: effects of bioenergy production on carbon dynamics
Creators: name: Akujärvi, Anu
name: Repo, Anna
name: Akujärvi, Altti M.
name: Liski, Jari
Publisher: name: figshare
Year: 2021
Subjects: subject: Ecology
subject: FOS: Biological sciences

description: Additional file 1: Figure S1 The development of the forest age class distribution in the Vanajavesi catchment area over the simulation period 2012-2100. Figure S2 The simulated (a) and measured (b) mean age class distribution in the study area in the beginning of the simulation period. The simulated and measured estimates represent the Vanajavesi catchment in 2012-2016 and the surrounding Kanta-Häme region in 2009-2013 (Natural Resources Institute Finland 2020), respectively.
Additional file 4 of Ovarian activation delays in peripubertal ewe lambs infected with Haemonchus contortus can be avoided by supplementing protein in their diets
Creators: name: Suarez-Henriques, Paula
name: de Miranda e Silva Chaves, Camila
name: Cardoso-Leite, Ricardo
name: Gomes-Caldas, Danielle G.
name: Morita-Katiki, Luciana
name: Tsai, Siu Mui
name: Louvandini, Helder
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: Additional file 4. Full list of differentially expressed genes in supplemented not infected vs control not infected groups-converted.
Single plate connections for steel beams
Creators: name: Wyss, Urs
Publisher: name: University of British Columbia
Year: 2011

description: Single plate connections for steel beams, connected by high strength bolts to the beam web and welded to the column, were investigated to determine their, behaviour. Tests were performed on the connections in the absence and in the presence of shear, and shear was found not to affect the rigidity of the connections. Varying the gauge distance, the weld size, the pitch and the number of bolts in the test specimens, showed that only the pitch and the number of bolts influenced the rigidity of the connections. An increase in the pitch and the number of bolts causes an increase in the rigidity of the connections. In all cases the major slip value was greater than the usually assumed value. Under the action of pure moment the centre of rotation was found to be slightly above the centroid of the connection, whereas under the action of moment and shear the centre of rotation was slightly below the centroid of the connection. The maximum moment developed by the connections varied from 45 kip-inches for the two-bolt connection, to 355 kip-inches for the six-bolt connection.
Analytic continuation average spectrum method for quantum liquids
Creators: name: Reichman, David R.
name: Rabani, Eran
Publisher: name: arXiv
Year: 2009
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: Quantum Gases (cond-mat.quant-gas)
subject: FOS: Physical sciences

description: We revisit the problem of determining the real-frequency density response in quantum fluids via analytical continuation of imaginary-time quantum Monte Carlo data. We demonstrate that the average spectrum method (ASM) is capable of revealing resolved modes in the dynamic structure factor of both ortho-deuterium and liquid para-hydrogen, in agreement with experiments and quantum mode-coupling theories, while the maximum entropy approach yields only a smooth unimodal spectrum. Outstanding issues are discussed. Our work provides the first application of the ASM method in realistic off-lattice systems.
description: 7 pages, 2 figures
Additional file 5 of Ovarian activation delays in peripubertal ewe lambs infected with Haemonchus contortus can be avoided by supplementing protein in their diets
Creators: name: Suarez-Henriques, Paula
name: de Miranda e Silva Chaves, Camila
name: Cardoso-Leite, Ricardo
name: Gomes-Caldas, Danielle G.
name: Morita-Katiki, Luciana
name: Tsai, Siu Mui
name: Louvandini, Helder
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: Additional file 5. Full list of differentially expressed genes in supplemented infected vs control infected groups-converted.
Transformations of one-dimensional Gibbs measures with infinite range interaction
Creators: name: Redig, Frank
name: Wang, Feijia
Publisher: name: arXiv
Year: 2010
Subjects: subject: Probability (math.PR)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We study single-site stochastic and deterministic transforma- tions of one-dimensional Gibbs measures in the uniqueness regime with infinite-range interactions. We prove conservation of Gibbsianness and give quantitative estimates on the decay of the transformed potential. As examples, we consider exponentially decaying potentials, and potentials decaying as a power-law.
Thermosphere and exosphere of Hot-Jupiters
Creators: name: Etangs, A. Lecavelier des
Publisher: name: arXiv
Year: 2009
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Here we describe the observations and the resulting constraints on the upper atmosphere (thermosphere and exosphere) of the "Hot-Jupiters". In particular, observations and theoretical modeling of Hot-Jupiter evaporation are described. The observations allowed the discovery that the planet orbiting HD209458 has an extended atmosphere of escaping hydrogen and showed the presence of oxygen and carbon at very high altitude. These observations give unique constraints on the escape rate and mechanism in the atmosphere of these planets. The most recent Lyman-alpha HST observations of HD189733b allows for the first time to compare the evaporation from two different planets in different environments. Models to quantify the escape rate from the measured occultation depths, and an energy diagram to describe the evaporation state of Hot-Jupiters are presented. Using this diagram, it is shown that few already known planets could be remnants of formerly giant planets.
description: Invited review at IAU Symposium 253 "Transiting planets". Pont F., Queloz D., Sasselov., Torres M., and Holman M., Eds
Faded Shine... Use and Degradation of Metal Brass Powder in two 19th Century Paintings.
Creators: name: Ferreira, E.S.B.
name: Gros, D.
name: Scherrer, Nadim
name: Zumbühl, Stefan
Publisher: name: (:null)
Year: 2014

description: During the examination of two 19th century oil paintings by Swiss artists, the Reading pastor (ca. 1885) by Ferdinand Hodler (1853–1918) and Portrait of a young girl (ca. 1888) by Filippo Franzoni (1857–1911), it was observed that in particular locations, the surface had an unusually granular texture, given by the application of metallic particles and the presence of large translucent green agglomerates. In this paper we investigate the composition and origin of the metal particles and green agglomerates. A combination of bulk analysis (GC–MS and FTIR) and analytical microscopy techniques (X-ray tomographic microscopy, light microscopy, ATR–FTIR–FPA imaging and SEM–EDX) were used. It was concluded that the metal particles are composed of a lower quality brass (copper/zinc alloy) and ground from foil. The current appearance resulted from the reaction of the brass and its corrosion products with the fatty acids in the surrounding paint/varnish matrix. This has lead to the formation of agglomerates of zinc and copper carboxylates, the latter responsible for their green colour.
REGENERATION-ASSOCIATED WNT SIGNALING ACTIVATION IN ACUTE MYELOID LEUKEMIA
Creators: name: CORLAZZOLI, FRANCESCA
Publisher: name: Universit� degli Studi di Milano
Year: 2012

description: Ample evidence exists in mouse models that acute myeloid leukemia (AML) develops through stepwise acquisition of collaborating genetic and epigenetic changes in self-renewing leukemia-initiating cells (LICs) that exhibit a committed myeloid immunophenotype. Recently, critical questions emerged regarding the characterization of LICs in the CD34+CD38- fraction and the AC133 antigen (a glycosylation-dependent epitope of CD133) seems to be one of the markers more appropriate to enrich for the LICs-containing fraction. The requirement of the Wnt/?-catenin pathway in the pathogenesis of acute myeloid leukemia (AML) has recently emerged in mouse models. However, its relationship to genetic programs promoting retention of self-renewing leukemia stem cells (LSCs) remains elusive. Hence, the need to identify transcriptional programs involved in the maintenance of a self-renewing state in LSCs. Given the predominant role of transcription factors (TFs) function in myeloid leukemia and recent progresses in reprogramming research for a critical role of TFs in the establishment and maintenance of cellular phenotypes, here we generated a specially designed transcriptional regulators (TRs) dataset to interrogate expression microarray data obtained from AC133+ cells in AML patients and healthy donors. Our data suggest that the canonical Wnt/?-catenin signaling is activated in leukemic human long-term reconstituting AC133+ restricted cells. In a series of molecular and functional studies we found that leukemic cells AC133+ synthesize and secrete WNT10B, a hematopoietic stem cells (HSCs) regenerative-associated molecule, and increase the levels of dephosphorylated ?-catenin. Nevertheless, AML AC133+ cells, in zebrafish embryos, are able to develop ectopic structures by activating organizer markers that act downstream of the Wnt pathway. In light of the long-known association between cancer and chronic tissue injury, and because of the higher homeostatic range of Wnt/?-catenin signaling occurring during regeneration upon an acute injury, altogether our data provide compelling evidence that regenerationassociated Wnt signaling exceeds the homeostatic range in human AML and affects responsive cells whose renewal is promoted by Wnt pathway activity.
NOVEL FUNCTIONS OF POLYCOMB PROTEINS AND OGT GLYCOSYLTRANSFERASEIN CHROMATIN REGULATION AND TRANSCRIPTION CONTROL IN EMBRYONIC STEM CELLS
Creators: name: SCELFO, ANDREA
Publisher: name: Universit� degli Studi di Milano
Year: 2015

description: During my PhD course, I have been involved in studies aiming to identify novel properties of proteins having fundamental roles in the regulation of chromatin modifications and gene transcription. One of the two project was focused on the functional characterization of the products of the catalytic activity of Polycomb Repressive Complex 2 (PRC2). In spite of the wide knowledge about PRC2-dependent trimethylation of Lysine 27 of histone H3 (H3K27me3), the other forms of methylation on H3K27, namely mono (me1) and di-methylation (me2), are still poorly characterized. Using mouse embryonic stem cells (mESC) as model system, we were able to provide an extensive characterization of the functional properties of these methylation forms, highlighting their differential deposition along the genome, their fundamental role in the mechanisms of transcriptional regulation in mESC, and their potential implications during differentiation program. Our data demonstrated that while H3K27me1 was required for efficient transcription of genes and positively correlated with the deposition of H3K36me3, H3K27me2 was broadly deposited and protects the genome from aberrant firing of non specific cell type enhancers. My second project focused on the activity of the O-linked glycosyltransferase Ogt which is the only enzyme capable to catalyze O-linked GlcNAcylation within the cell. Sxc protein, which is the Drosophila orthologue of mammalian Ogt, is essential for Polycomb (PcG) function. Sxc null embryos showed lethal phenotypes at early developmental stages like those observed in PcG null embryos. Starting from this observation we found appealing to investigate whether Sxc function in Drosophila were conserved in mammals. In particular, we were interested in the discovery of possible role for Ogt in the context of PcG recruitment to chromatin and the mechanisms governing transcriptional regulation in mESC. With our study we have identified a novel partnership between Ogt and ten-eleven translocation (TET) proteins, which catalyze hydroxylation of methylated cytosine. We have shown that Tet1 protein recruits Ogt to target genes in proximity of transcription start sites (TSS) rich in cytosine-guanine dinucleotides (CpG). Tet1-Ogt co-localization at target genes correlated with low levels of cytosine modification, suggesting a role in the regulation of CpG island (CpGi) methylation.
title: Flow and fiber orientation of fresh fiber reinforced concrete
Creators: name: Gerland, Florian
name: Schomberg, Thomas
name: Kuhl, Detlef
name: Wünsch, Olaf
Publisher: name: Universität Kassel
Year: 2021
Subjects: subject: 620
subject: Faserbeton
subject: Ultrahochfester Beton
subject: Rheologische Eigenschaft
subject: Fließverhalten

description: Gefördert im Rahmen des Projekts DEAL
Unsymmetric loading of a framed dome
Creators: name: Fox, Selwyn Perrin
Publisher: name: University of British Columbia
Year: 2011

description: The linear analysis of a specific framed dome is mapped for the unsymmetric loadings of half snow and wind. The joints of the dome, to which the loads are applied, lie on a spherical surface but the connecting members are straight. Several parameters, such as the perimeter ring size, the web member area, geometric conformity, and joint fixity, are changed and the effects of these changes are compared and discussed. It is shown that membrane shell theory closely approximates the member forces induced by wind. An approximate system to find the member forces is presented and compared with the exact analysis. This system is based on overall structure equilibrium and an assumed distribution of edge shear. All analyses were made using a space frame program based on the stiffness method with six degrees of freedom per joint; An IBM 7040 computer was used for calculations.
Additional file 7 of Ovarian activation delays in peripubertal ewe lambs infected with Haemonchus contortus can be avoided by supplementing protein in their diets
Creators: name: Suarez-Henriques, Paula
name: de Miranda e Silva Chaves, Camila
name: Cardoso-Leite, Ricardo
name: Gomes-Caldas, Danielle G.
name: Morita-Katiki, Luciana
name: Tsai, Siu Mui
name: Louvandini, Helder
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: Additional file 7: Figure S1. Enriched terms in up-regulated genes between Supplemented Not Infected vs Control Not Infected.
The loneliness of the pro-government backbencher and the precariousness of simple majority rule Tuvalu
Creators: name: Panapa, Paulson
name: Fraenkel, Jon
Publisher: name: Canberra, ACT: State, Society and Governance in Melanesia (SSGM) Program, Research School of Pacific and Asian Studies, The Australian National University
Year: 2008
Subjects: governance
Tuvalu

description: "In this paper, we analyse the twists and turns of Tuvalu central government politics, particularly since the two elections of 1993, and consider an alternative framework which entails the abandonment of the unhappy institutionalisation of the opposition as a government-in-waiting, the introduction of an eight member executive representing all the islands, and the adoption of a stronger oversight role for the island-based Falekaupule. In the first part of the paper, we outline the institutional and political framework established in Tuvalu at independence, and the way this has developed in the period thereafter. In the second part, we review the succession of governments, why each fell and how each sought to engineer for itself a longer term in office. In the final part, we review the 1997 Falekaupule Act and the operation of local level assemblies, and set out our alternative framework, asking whether this might better fit the local customary framework as well as improving the quality of central government performance. ..." page 2
Additional file 6 of Ovarian activation delays in peripubertal ewe lambs infected with Haemonchus contortus can be avoided by supplementing protein in their diets
Creators: name: Suarez-Henriques, Paula
name: de Miranda e Silva Chaves, Camila
name: Cardoso-Leite, Ricardo
name: Gomes-Caldas, Danielle G.
name: Morita-Katiki, Luciana
name: Tsai, Siu Mui
name: Louvandini, Helder
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases
subject: Computational Biology

description: Additional file 6. Full list of differentially expressed genes in control infected vs supplemented infected.
Well-posedness for one-dimensional derivative nonlinear Schrödinger equations
Creators: name: Hao, Chengchun
Publisher: name: arXiv
Year: 2008
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 35Q55; 35A07

description: In this paper, we investigate the one-dimensional derivative nonlinear Schrödinger equations of the form $iu_t-u_{xx}+iλ\abs{u}^k u_x=0$ with non-zero $λ\in \Real$ and any real number $k\gs 5$. We establish the local well-posedness of the Cauchy problem with any initial data in $H^{1/2}$ by using the gauge transformation and the Littlewood-Paley decomposition.
description: 25 pages
Photonic analog of graphene model and its extension -- Dirac cone, symmetry, and edge states --
Creators: name: Ochiai, Tetsuyuki
name: Onoda, Masaru
Publisher: name: arXiv
Year: 2009
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: This paper presents a theoretical analysis on bulk and edge states in honeycomb lattice photonic crystals with and without time-reversal and/or space-inversion symmetries. Multiple Dirac cones are found in the photonic band structure and the mass gaps are controllable via symmetry breaking. The zigzag and armchair edges of the photonic crystals can support novel edge states that reflect the symmetries of the photonic crystals. The dispersion relation and the field configuration of the edge states are analyzed in detail in comparison to electronic edge states. Leakage of the edge states to free space is inherent in photonic systems and is fully taken into account in the analysis. A topological relation between bulk and edge, which is analogous to that found in quantum Hall systems, is also verified.
description: 9 pages, 7 figures
title: Matching Countermeasures to Driver Types and Speeding Behavior  [Traffic Tech]
title: Traffic Tech : Matching Countermeasures to Driver Types and Speeding Behavior
titleType: AlternativeTitle
Creators: name: National Highway Traffic Safety Administration
Publisher: name: National Highway Traffic Safety Administration
publisherIdentifier: https://ror.org/04gcfqs37
publisherIdentifierScheme: ROR
Year: 2017
Subjects: classificationCode: https://trt.trb.org/term/91555
subject: Age groups
classificationCode: https://trt.trb.org/term/91865
subject: Attitudes
classificationCode: https://trt.trb.org/term/91863
subject: Behavior
classificationCode: https://trt.trb.org/term/90645
subject: Countermeasures
classificationCode: https://trt.trb.org/term/91520
subject: Demographics
classificationCode: https://trt.trb.org/term/91739
subject: Drivers
classificationCode: https://trt.trb.org/term/91564
subject: Gender
classificationCode: https://trt.trb.org/term/88439
subject: Measures of effectiveness
classificationCode: https://trt.trb.org/term/90686
subject: Speeding
classificationCode: https://trt.trb.org/term/97433
subject: Surveys

description: Speeding is a common behavior; most drivers exceed the speed limit some of the time. It is also a complicated behavior that varies by driver and situation. Speeding-related crashes take a large annual toll in injuries, lost lives, and high economic costs in the United States. Speeding is a safety problem requiring serious attention. This study explored driver speeding typologies developed in two previous NHTSA studies, the 2011 National Survey of Speeding Attitudes and Behaviors (NSSAB) (Schroeder, Kostyniuk, & Mack, 2013) and Motivations for Speeding (Richard et al., 2013). An address-based mail survey was conducted in Idaho using a sample drawn from deidentified driver records obtained from the Idaho Transportation Department (ITD). The sample was stratified by age, gender, and number of speeding convictions (0, 1, and 2+ in the last three years). Younger drivers and those with 2+ convictions were oversampled relative to the general population. A total of 1,925 returned surveys were included in the analyses. Survey respondents included males (52%) and females (48%). There were three age groups: younger drivers 18 to 24 (11.2%), drivers 25 to 64 years old (70.6%), and older drivers 65+ (18.2%). Within these demographic categories, drivers were selected based on number of convictions in the previous 3 years. These included drivers with 0 convictions (49.5%), 1 conviction (19.4%), and 2+ convictions (31.1%). Drivers with 2+ convictions were greatly overrepresented in the sample relative to the Idaho driving population due to oversampling of this group of primary interest.
NEW SIGNALING PATHWAYS REGULATING SCHWANN CELLS OF THE PERIPHERAL NERVOUS SYSTEM: IMPLICATIONS IN PERIPHERAL NEUROPATHIES.
Creators: name: MELFI, SIMONA
Publisher: name: Universit� degli Studi di Milano
Year: 2018

description: The origin, development and maturation of Schwann cells (SCs), the main glial cells of the peripheral nervous system (PNS), are a set of complicated and intriguing processes. These multifactorial processes take place following a precise and unique coordination between different molecules and intracellular signaling, that interact with a complex of endogenous and exogenous signals. Among these, there are integrins, neuregulins, growth factors, hormones, neurotransmitters and intracellular pathway, including protein kinase A and protein kinase C (PKA and PKC), serine/threonine kinase 1 (AKT), extracellular regulated MAPK/mitogen-activated protein kinase 1 (ERK/MAPK), Hippo, mechanistic target of rapamycin (mTOR), etc. This thesis is focused on some novel intracellular signaling pathways involved in the SCs development and maturation, from their origin to the acquisition of the myelinating or repairing phenotype. The first part of the thesis focuses on a proto-oncogene, the non-receptor tyrosine kinase SRC (SRC), and the focal adhesion kinase (FAK), which are intermediate pathways known to play a role in the control of adhesion, motility, and migration of SCs. It has been investigated whether these pathways are regulated by allopregnanolone (ALLO), a neuroactive steroid of peculiar interest for the control of SCs maturation. The second part of this thesis focuses on the study of the Hippo signaling pathway, known to be a key regulator of proliferation, apoptosis, control of organ size and crucial for cancer proliferation. Hippo pathway has been studied in SCs, where it is linked to Merlin (an oncosuppressor protein) and Yes associated protein/tafazzin (YAP/TAZ) factors. Interestingly, these mechanisms were responsive to physical and environmental challenges. Lastly, the third part of this thesis move on studying the role of the g?-aminobutyric acid (GABA) system in the control of peripheral myelination. In particular, the whole expression profile was investigated in conditional knock out mice for the B1 subunit of the GABA-B receptor (GABA-B R), with a specific deletion in SCs. By the use of microarray technology, several genes resulted up- or downregulated in SCs, opening new perspectives on the possible targets downstream GABA-B R in SCs. Overall, these results highlight new aspects of the SCs biology, shedding light on unraveled mechanisms and underlying their importance in the development and maturation of these specialized cells of the PNS. This may be of pharmacological and therapeutically interest, in order to identify reliable approaches for the treatment of PNS diseases.
Superconductivity of Various Borides: The Role of Stretched c- Parameter
Creators: name: Mudgel, Monika
name: Awana, V. P. S.
name: Kishan, H.
name: Felner, I.
name: Alvarez, Dr. G. A.
name: Bhalla, G. L.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The superconductivity of MgB2, AlB2, NbB2+x and TaB2+x is inter-compared. The stretched c-lattice parameter (c = 3.52 A) of MgB2 in comparison to NbB2.4 (c = 3.32 A) and AlB2 (c = 3.25 A) decides empirically the population of their p and s bands and as a result their transition temperature, Tc values respectively at 39K and 9.5K for the first two and no superconductivity for the later. Besides the electron doping from substitution of Mg+2 by Al+3, the stretched c-parameter also affects the Boron plane constructed hole type Sigma-band population and the contribution from Mg or Al plane electron type Pi band. This turns the electron type (mainly Pi-band conduction) non-superconducting AlB2 to hole type (mainly s-band conduction) MgB2 superconductor (39 K) as indicated by the thermoelectric power study. Keeping this strategy in mind that stretching of c-parameter enhances superconductivity, the NbB2+x and TaB2+x samples are studied for existence of superconductivity. The non-stoichiometry induces an increase in c parameter with Boron excess in both borides. Magnetization (M-T) and Resistivity measurements (R-T) in case of niobium boride samples show the absence of superconductivity in stoichiometric NbB2 sample (c = 3.26 A) while a clear diamagnetic signal and a R = 0 transition for Boron excess NbB2+x samples. On the other hand, superconductivity is not achieved in TaB2+x case. The probable reason behind is the comparatively lesser or insufficient stretching of c-parameter.
description: 14 pages Text+Figs contact (awana@mail.nplindia.ernet.in). ACCEPTED: J. APPL.PHYS. (MMM-2008 Proceedings)
IL DUALISMO DEL FEMMINILE NEL 'NERONE' DI BOITO. TESTO E INTERPRETAZIONE
Creators: name: CAMPONOVO, PAOLA
Publisher: name: Universit� degli Studi di Milano
Year: 2018

description: The object of the present doctoral dissertation is Arrigo Boito?s last opera "Nerone" (Milan, Teatro alla Scala, 1924), a work whose compositional process spans over sixty years, from the 1840s until the composer?s death (1918), when it was left unfinished. Due to the abundance of sources, I have chosen to narrow my analysis down to gender issues, focusing on the opera?s two main female characters, Asteria and Rubria, in order to place Boito?s work within the fin de si�cle operatic and cultural context. After an introduction about the pervasive gender-oriented representations of Nero in art and literature during the second half of the 19th century, the first chapter is devoted to philological problems and to Boito?s sources for his "Nerone". The second one focuses on the musical, visual and dramaturgical aspects of those episodes in the opera in which the feminine element is central, with the analysis of decadent properties in Boito?s work. The entire third chapter is dedicated to Asteria, here considered as a hysterical woman, furthermore suggesting a connection with Eleonora Duse, who was the composer?s lover around the last two decades of the 19th century. Finally, the last chapter zooms in on the question of voice and gender in Boito?s production, arguing for a connection between his heroines ? in particular, but not exclusively, those of "Nerone" ? and the fin de si�cle topics of the femme fatale and the femme fragile.
KYC using Blockchain
Creators: name: Sreelakshmi V G
Publisher: name: figshare
Year: 2020
Subjects: subject: 150305 Human Resources Management
subject: FOS: Economics and business

description: Nowadays everyone uses their personal identification documents on a regular basis, which gets shared with third parties without their explicit consent and stored at an unknown location. Companies such as government institutions, banks, credit agencies and other financial organizations are considered to be the weakest point in the current identity management system as they are unfortified to theft and hacking of data. Although the financial services sector have been seeking solutions for identity problem for a long time, it is only now that a viable solution has arrived in form of blockchain. KYC Know Your Customer using Blockchain eliminates the repeated KYC checks that banks currently perform by maintaining a common secure database in a blockchain. The nature of a blockchain ensures that unauthorized changes to the data are automatically invalidated. The proof of reputation concept makes the verification process more robust and secure. Decentralized computing architecture, blockchain will allow for the accumulation of data from multiple authoritative service provider into a single immutable, cryptographically secured and validated database. Blockchain KYC solution take advantages of a secure, public digital ledger to give almost instantaneous and truly secure verification of identity. Due to the immutable and unalterable nature of the record kept in the blockchain, fraud could become a thing of the past. Sreelakshmi V G | Meera P M | Senna Mariya Pius | Mathews Jose | Swapna B Sasi "KYC using Blockchain" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-4 , June 2020, URL: https://www.ijtsrd.com/papers/ijtsrd31542.pdf Paper Url :https://www.ijtsrd.com/computer-science/other/31542/kyc-using-blockchain/sreelakshmi-v-g