cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
The Transcriptional Regulation of Premyogenic Mesoderm Factors during Skeletal Myogenesis
Creators: name: Mehta, Virja
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Chemistry, Biochemistry.

description: A complex network of transcription factors, which are regulated by signalling molecules, is responsible in coordinating the formation of differentiated skeletal myocytes from the undifferentiated state. The present study aims to understand and compare the transcriptional regulation of skeletal muscle progenitor and MRFs through beta-catenin- and MyoD-induced P19 EC cell differentiation. Furthermore, the study aims to compare the expression pattern of transcription factors that mark either the epaxial or hypaxial domain of the differentiated somite of the developing embryo in DMSO-, beta-catenin- and MyoD induced P19 EC cell differentiation. First, stable expression of an active beta-catenin in P19 cells was sufficient to induce the expression of the premyogenic mesoderm factors such as Pax3/7, Meox1, Gli2, Foxc2, in addition to the somitic marker Foxc2. Knock-down of beta-catenin, by shRNA, resulted in a decreased expression of these factors, and a downregulation of the MRFs, indicating that beta-catenin is essential for myogenesis. DMSO-induced differentiation led to the upregulation of Sim1 and Lbx1, whereas beta-catenin-induced differentiation did not show any significant changes to either. Second, gain- and loss-of-function experiments demonstrated that MyoD directed P19 cells into the skeletal muscle lineage by inducing the expression of Meox1, Pax7, Six1, and Eya2, on day 4 and eventually Pax3 leading to the subsequent upregulation of the MRFs. Chromatin immunoprecipitation experiments showed that MyoD bound directly to the regulatory regions of Pax3/7, Eya2, Six1, Meox1 and myogenin. Furthermore, MyoD-induced differentiation upregulated the expression of Lbx1 and C-met and had relatively unchanged levels of En1 and Sim1 expression. These results demonstrate that MyoD re-directs P19 cells into the skeletal muscle lineage by directly binding to the regulatory regions of several premyogenic mesoderm genes, leading to the formation of skeletal muscle that express the transcription factors C-met and Lbx1, both of which are shown to be essential in limb, diaphragm and tongue muscle formation in the embryo. These studies have provided an understanding of the transcriptional regulation of premyogenic mesoderm factors in both beta-catenin- and Myod-induced differentiation, with further insight into the type of skeletal muscle that may be forming in P19 EC cells.
Stability and Chaos in Multi-Planet Systems: The Role of Mean-Motion Resonances and Secular Dynamics
Creators: name: Liu, Zhixing
Publisher: name: Zenodo
Year: 2023

description: This study investigates the optimal packing of multi-planet systems through numerical N-body simulations. Previous studies assumed that a system will be optimally packed if they are equally spaced. We explicitly test this assumption by examining the stability timescales of 5-planet, 10-planet, and 15-planet systems around a Sun-like star with increasing degrees of non-uniform-spacing represented by the parameter 0 < k < 1, with a value of k = 1 corresponding to equal spacing, whereas a value of k < 1 lead to the inner planets being more widely spaced than outer planets. We find that the optimal value of k for the longest stability time gradually deviates from k = 1 with increasing semi-major axis range and system multiplicity distribution. We additionally demonstrate the role of mean-motion resonances (MMRs) in determining the configurations of optimal planet packing, examine the eccentricity evolution of the planetary system, and present a simulation of the secular evolution of the system.
Exploring the Origin of Metastability in Multi-Planet Systems Through Angular Momentum Deficit Accumulation
Creators: name: Zhixing Liu
name: Pu, Bonan
Publisher: name: Zenodo
Year: 2024

description: Numerical studies have shown that multi-planet systems on initially nearly circular, co-planar tend to auto-excite dynamically, eventually leading to systemic instability. The timescale of this instability grows exponentially with mean planet spacing and may not be reached for billions of orbits. Various competing explanations have been proposed to explain the origins of this eventual instability, and it is not known whether all multi-planet systems are metastable and will eventually destabilize or a critical spacing exists beyond which the system is expected to be perpetually stable. We present numerical simulations testing prior hypotheses for the pathway to instability: we examine the challenges faced by the two-body and three-body MMR overlap models in accurately predicting encounter times as the number of planets in a system increases. We find that although two-body MMR overlap theory traditionally favors equal spacing to minimize the optical depth of MMRs, systems with a more significant number of planets and varied planetary masses tend to destabilize more rapidly under such conditions, compared with an unequal spacing regime where planets with higher angular momentum are packed more tightly. Our results suggest that global transport of AMD facilitated by secular interactions may play a key role. We present a novel mode diffusion theory to illustrate how mild and bounded aperiodicity in planet semimajor axes can cause planet systems to accumulate global AMD. If this theory is correct, it suggests that all planet systems are only metastable but have a long instability time dispersion.
Numerical Investigations of Non-equal Mass and Non-equal Spacing Packing of Planetary Bodies
Creators: name: Zhixing Liu
Publisher: name: Zenodo
Year: 2022

description: The optimal packing of non-equally massed and non-equally spaced multi-planet systems through numerical N-body simulations are studied and the recent results will be presented. Previous studies have generally assumed that a system of equal mass planets will be optimally packed if they are also equally spaced, i.e., if the semi-major axis ratios between planet pairs is a constant. We explicitly test this assumption by obtaining the stability timescales of 5-planet systems around a Sun-like star (with masses varying from 3 Earth masses to 3 Jupiter masses) with increasing degrees of non-uniform-spacing represented by the parameter 0 < k < 1. For planets with equal masses, a value of k = 1 corresponds to equal spacing, whereas a value of k < 1 leads to the inner planets being more widely spaced than outer planets. We study the optimal value of k for optimal planet packing (i.e., longest stability time) under both equal mass and non-equal mass scenarios and find evidence that k = 1 may not be optimal under all scenarios and. We also find system stability will decrease with the increase of mass variation. The role that distance to mean-motion resonances (MMRs) and Fourier analysis of complex eccentricity play in determining the configurations of optimal planet packing will also be demonstrated. The distinction of different exponents and different mass variation in system stability is potentially explained by their MMR distributions and complex eccentricity frequency. The graph illustrations for both cases will also be presented.
ANTENNA COMPRISING AN UNMANNED AIRCRAFT
Creators: name: Broyde, Frederic
name: Clavelier, Evelyne
Publisher: name: WIPO
Year: 2018

description: The invention relates to an antenna for radiocommunication, for instance an antenna for radio reception and/or radio emission in the frequency range 1.8 MHz to 30 MHz. The antenna comprises a tethered unmanned aircraft and a coupling network.
Revitalising documentary archives Exploring methods of digital distribution
Creators: name: Lotman, Nicolas
name: van Ravenhorst, Jeroen
Publisher: name: Zenodo
Year: 2024
Subjects: Languages of Tanzania
Language mobilization
Endangered languages
Language documentation
Language Archivation
Descriptive linguistics

description: Language documentation or documentary linguistics is concerned with compiling long lasting multipurpose records of natural language (Himmelmann 1998; 2006; Austin & Grenoble 2007). Austin (2010) identifies five components of language documentation practice, the last component being “mobilisation”, which deals with the “creation, publication and distribution of outputs, in a range of formats for a range of different users and uses” (2010: 19). In practice, language documentation outputs tend to remain obscure to the community, being hidden in user-unfriendly online archives, even though the materials themselves are potentially of great value and interest to the community. It is therefore crucial that the documentary linguist recognises their responsibility beyond compiling and archiving of materials, ensuring that the outputs are accessible for the speaker community.

In this presentation, we firstly aim to elaborate on the current definition of mobilisation as given by Austin (2010). Then, taking a modernising setting into account, we suggest practical ways to share and promote documentary outputs digitally among communities in accessible, usable, and digestible formats. We also highlight the importance of localised solutions which account for local means of access, compatibility of platforms, and related issues such as varying rates of (digital) literacy in sharing the documentary materials. Finally, to help ensure better outreach and community awareness of the materials, we stress the benefits of cooperating with active and digitally literate community members who have existing networks of digital content distribution.

 

References:

Austin, P. K., & Grenoble, L. A. (2007). Current trends in language documentation. Language documentation and description, 4.

Austin, P. K. (2010). Current issues in language documentation. Language documentation and description, 7.

Himmelmann, N. P. (1998). Documentary and descriptive linguistics. Linguistics, 36(1), 161-196.

Himmelmann, N. P. (2006). Language documentation What is it and what is it good for. Essentials of language documentation, 178(1).
description: Note: This talk has not gone through a process of peer review, and findings should therefore be treated as preliminary and subject to change.

Acknowledgement and citation: Van Ravenhorst, Jeroen & Nicolas Lotman. 2024. Revitalising documentary archives: Exploring methods of digital distribution. Talk given at the Rift Valley Network Webinar Series. 29/05/2024.
OLIMPIYA O'YINLARIDA BADIIY GIMNASTIKA
Creators: name: Farhodova, Maftuna
Publisher: name: Zenodo
Year: 2024

description: Ushbu maqolada Olimpiya o'yinlarida badiiy gimnastikaning rivojlanishi va ahamiyati tahlil qilinadi. Badiiy gimnastika bo'yicha Olimpiya musobaqalarining tarixi, qoidalari va zamonaviy tendensiyalari ko'rib chiqiladi. Shuningdek, O'zbekiston terma jamoasining so'nggi yillardagi yutuqlari va istiqbollari muhokama qilinadi.
A framework for provisioning reliable services in multi-domain networks
Creators: name: Saad, Tarek W
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2009
Subjects: subject: Engineering, Electronics and Electrical.

description: The global Internet is effectively a loose collection of semi-autonomous constituent networks. Each of these operates with its own policies, services, prices, and customers making independent decisions about where and how to secure supply of various components that are needed to create the network service. The next generation network is about convergence of multiple services onto a single multilayered network. A service or quality offered by the network is envisaged as a concatenation of dissimilar services offered at multiple switching layers and domains. Consequently, control plane mechanisms must support the routing of service requests through a series of regions using dissimilar convergence layers. Generalized Multi-Protocol Label Switching (GMPLS) protocol suite has been extensively deployed to provide consistent quality of service (QoS) within intra-domain boundaries. This process is simple and efficient when a GMPLS Label Switched Path (LSP) involves only one domain, but can potentially become severely resource heavy, complex, and inefficient when multiple domains are involved. The Path Computation Element (PCE) has been introduced as a candidate solution to solve this. A PCE collects link-state information and performs path computation on behalf of other network nodes. Since the PCE is completely devoted to path computation, the visibility of network resources can be extended including a higher number of network nodes and layers. In this thesis, we propose several novel schemes and heuristics that are suitable for the implementation in multi-domain hierarchical networks. The proposed schemes address the dynamic provisioning of service constrained and/or failure-disjoint paths for point-to-point, as well as point-to-multipoint TE LSPs.
СИСТЕМАТИЧЕСКИЙ ОБЗОР ЭСТЕТИЧЕСКИХ ПРОБЛЕМ, СВЯЗАННЫХ С ДЕНТАЛЬНЫМИ ИМПЛАНТАТАМИ В ЭСТЕТИЧЕСКОЙ ЗОНЕ
Creators: name: Сапарбаев, Закир
Publisher: name: Zenodo
Year: 2024

description: В данной статье представлен систематический обзор эстетических проблем, связанных с установкой дентальных имплантатов в эстетической зоне полости рта. Эстетическая зона, охватывающая участки от клыка до клыка, требует особого внимания при имплантации, так как окружающие мягкие ткани и имплантаты находятся на виду при улыбке, что делает эту зону чувствительной для пациентов. Обзор включает анализ таких эстетических аспектов, как потеря краевой кости, изменения мягких тканей и достижение высоких показателей розовой эстетики. Рассмотрены результаты исследований, в которых использовались различные подходы к имплантации, такие как техника защиты лунки и стандартные методы. Исследования показали, что техника защиты лунки (SST) обладает преимуществами по сравнению с традиционными методами в плане снижения эстетических осложнений. Представленные данные подчеркивают важность тщательного планирования лечения, управления мягкими тканями и учета эстетических ожиданий пациентов для достижения оптимальных результатов имплантации.
Peter Schnabel: Vom Ruhrpott nach Shanghai. Wie das Essener Unternehmen RWE in weniger als einem Jahrzehnt zum Global Player wurde und den Weg in Asiens Millionenstädte fand
Creators: name: Clemens, Jürgen
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 92 (2004): ASIEN (Juli)
Approaches to implementing an influenza vaccine decision aid for healthcare personnel
Creators: name: Lam, Po-Po
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Health Sciences, Epidemiology.
subject: Health Sciences, Health Care Management.

description: The Ottawa Influenza Decision Aid (OIDA) is a newly developed tool to assist healthcare personnel (HCP) make an informed decision regarding the seasonal influenza vaccine. The primary objective of this thesis is to determine approaches to implementing the OIDA into healthcare organizations by 1) conducting a systematic review of influenza immunization campaigns for HCP; 2) facilitating consultation meetings with healthcare organizers to collect their ideas on using the OIDA within their workplace; and 3) develop an OIDA implementation questionnaire based on the findings from the systematic review and consultation meetings. The systematic review results suggest that education-only campaigns only have a minimal impact on immunization rates. Future studies require improved reporting on the follow-up of HCP and calculation of HCP immunization rates. The consultation meetings identified ten approaches to implementing the OIDA within a healthcare setting. The OIDA Implementation Questionnaire was designed and a survey implementation approach recommended.
Case Study: COpAPS – A Case Study in Social Agriculture
Creators: name: LOBA - Customer Experience Design
name: Avans University of Applied Sciences
name: FVA New Media Research (Italy)
name: University of Bologna
name: Q PLAN International (Greece)
Publisher: name: Zenodo
Year: 2024

description: Explore this case study collected by BioGov.net partners in Italy! This valuable resource provides a quick and comprehensive understanding of the COpAPS – A Case Study in Social Agriculture case study.
E-LIS: the open archive for library and information science
Creators: name: Morrison, Heather
name: Subirats Coll, Imma
name: Medeiros, Norm
name: De Robbio, Antonella
Publisher: name: Charleston Advisor
Year: 2008

description: E-LIS is an open access archive for library and information science. With over 5,800 documents as of June 2007 (over 5,000 in February 2007 when the archive was investigated in-depth), E-LIS is the world’s largest archive for LIS. Over half the documents in ELIS are peer-reviewed. E-LIS is particularly strong in English and Spanish language documents, but supports over 22 languages. With this multilingual support and a global team of volunteer editors, E-LIS has significant diversity in content, an advantage over traditional, english-based LIS resources. Not surprising, this tool designed by and for librarians features robust and user friendly search options. Lack of phrase searching, and pointing to a cross-archiving searching tool no longer supported when much better options are available, are identified as areas for improvement.
Eun-Jeung Lee: "Anti-Europa". Die Geschichte der Rezeption des Konfuzianismus und der konfuzianischen Gesellschaft seit der frühen Aufklärung. Eine ideengeschichtliche Untersuchung unter besonderer Berücksichtigung der deutschen Entwicklung
Creators: name: Pfenning, Werner
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 92 (2004): ASIEN (Juli)
Constuction des normes, entre stratégie et communication: Un cas de négotiation collective
Creators: name: Parent, Marc-Antonie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2006
Subjects: subject: Engineering, System Science.

description: Nous décrivons un processus de négociation, afin d'identifier l'interaction entre l'argumentation, basée sur des principes, et le marchandage, basé sur un rapport de force. Selon Bent Flyvbjerg, le pouvoir permet des manquements systématiques à l'éthique communicative prônée par Jurgen Habermas comme une nécessité philosophique. Selon Joseph Heath, l'exercice du pouvoir stratégique est de facto limité par les normes sociales, qui ont concrètement besoin de l'éthique communicative pour appliquer les sanctions. Nous avons procédé à une observation participante dans un cadre de la renégociation d'une convention collective, et analysons l'emploi des arguments dans nos données ethnographiques. Notre analyse montre en effet des défauts dans l'argumentation, mais qui ne sont pas explicables simplement selon le pouvoir où les normes sociales. Nous proposons une superposition des niveaux d'analyse stratégique, normative, dramaturgique et communicationnelle. Nous identifions également une collusions qui maintient certains dissensus, interprétés, selon Habermas, comme résistance à la convention comme média gouvernant.
Factors associated with spontaneous clearance of hepatitis C virus among illicit drug users
Creators: name: Grebely, Jason
name: Raffa, Jesse Daniel
name: Lai, Calvin
name: Krajden, Mel
name: Conway, Brian
name: Tyndall, Mark
Publisher: name: The University of British Columbia
Year: 2017

description: BACKGROUND: Spontaneous clearance of hepatitis C virus (HCV) occurs in approximately 25% of individuals. METHODS: To better understand the characteristics associated with clearance, the present study evaluated HCV clearance in a community-based cohort study. The Community Health and Safety Evaluation project recruited 3553 individuals via community organizations and door-to-door canvassing of a random sample of single occupancy hotels in the community to monitor uptake of health services and to estimate the incidence of communicable infections. Cohort data were linked with longitudinal laboratory databases, including HCV antibody and polymerase chain reaction assay results. RESULTS: Overall, 762 individuals had HCV antibody and RNA testing performed between 1999 and 2005. Spontaneous HCV clearance was observed in 179 individuals (23.5%), while HCV persistence was observed in 583 individuals (76.5%). The ability to develop protective immunity against HCV, as demonstrated by viral clearance, occurred more often in individuals of Aboriginal ethnicity (adjusted OR [AOR] 2.9, 95% CI 2.0 to 4.3; P<0.001) and female individuals (AOR 1.6, 95% CI 1.1 to 2.4; P=0.01). The rate of spontaneous HCV clearance was reduced in individuals using any type of illicit drugs (AOR 0.54, 95% CI 0.29 to 1.00; P=0.05) and those with HIV coinfection (AOR 0.58, 95% CI 0.38 to 0.88; P=0.01). Of 218 HIV-infected subjects, 48 of 51 (94%) in whom the order of HCV and HIV infection was established were infected with HCV a median of 2.4 years (range 0.2 to 10 years) before becoming infected with HIV. CONCLUSIONS: Aboriginal ethnicity and female sex were associated with increased rates of HCV clearance, while HIV coinfection and illicit drug use were associated with increased HCV persistence.
Pseudomonas aeruginosa biofilms in drinking water and the evolution of antibiotic resistance
Creators: name: Jurgens, Dawn Julie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2008
Subjects: subject: Biology, Microbiology.
subject: Health Sciences, Immunology.

description: In nature, bacteria grow attached to surfaces in communities called biofilms. Biofilm bacteria are phenotypically distinct from free-floating planktonic bacteria, and one of the phenotypic characteristics of biofilms is that they are highly resistant to antimicrobials. Because of this, biofilms growing inside water distribution systems are not killed by the residual water disinfectant. Bacteria that live inside drinking water distribution system biofilms are under stress due to the constant exposure to the residual disinfectant and the nutritional stress of living in an oligotrophic environment. These stresses can activate the bacterial stress response mechanisms, resulting in increased mutation rates. The mutations that occur are random, but the possibility exists for a mutation to arise that confers increased resistance to antibiotics. The objective of this study was to determine if biofilm bacteria acquire antibiotic resistance when exposed to the residual water disinfectant chloramine. I grew biofilms of Pseudomonas aeruginosa in drinking water bioreactors and treated them with chloramine. The bacteria were sampled over time for isolates that were resistant to ciprofloxacin; isolates were obtained from both the chloramine treated and control biofilms. The ciprofloxacin-resistant isolates had some phenotypic differences from the wildtype P. aeruginosa, as well as being resistant to rifampicin and chloramphenicol, but not resistant to tobramycin and gentamicin.
France Bevk Public Library Citizen Science Case Study
Creators: name: Vidmar, Saša
name: Montanari, Madeleine Cléa
Publisher: name: Zenodo
Year: 2024
Subjects: Public libraries
Citizen Science
Scientific activities

description: France Bevk Public Library Citizen Science Case Study is a case study of how France Bevk Public Library situated in Nova Gorica (Slovenia) has developed citizen science activities at their public library. It focuses on one of their activity, which is a Seed Library. 

This case study informs the reader about the library itself, gives an executive summary, how its citizen science project connects to the mission, how the seed library came to be, how it was implemented, partnerships and collaboration, community engagement, resources used, its promotion, impacts, challenges and solutions and lessons learned. 

This case study is and was used as a training material as part of the 'Citizen Science at Your Library' course, carried out by SciStarter and the ECS Academy in March 2024.

This case study is a source of inspiration and know how on what type of citizen science activty can emerge wtihin a public library. 

This case study is under the Creative Commons Attribution-Non Commercial- NoDerivs 4.0 International. This entails the following rights: 

You are free to:

Share — copy and redistribute the material in any medium or format

The licensor cannot revoke these freedoms as long as you follow the license terms.

Under the following terms:

Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

NonCommercial — You may not use the material for commercial purposes .

NoDerivatives — If you remix, transform, or build upon the material, you may not distribute the modified material.

No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
ABU NASR FOROBIYNING PSIXOLOGIK QARASHLARI
Creators: name: Baxtiyorova, Umida
Publisher: name: Zenodo
Year: 2024

description: maqolada buyuk ajdodimiz Abu Nasr Farobiyning  psixologik qarashlari, uning bugungi kunga qadar qiymati, psixologik va falsafiy g'oyalarga ta'siri, uning asarlari insonni haqiqat va uyg'unlikka intilayotgan aqlli va axloqiy mavjudot sifatida yaxshiroq tushunishga yordam berishi, allomaning psixologik qarashlari psixologik fikr tarixiga muhim hissa qo'shganligi, uning ruh, aql, bilim, iroda va axloq haqidagi asarlarining psixologiya va falsafaning keyingi rivojlanishidagi ahamiyati haqida so‘z boradi.
An Implementation of Resource Advertising and Discovery for Optical Research Networks
Creators: name: Jian, Jun
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2010
Subjects: subject: Engineering, Electronics and Electrical.

description: In optical research networks, the need to enable network users to dynamically provision and manage network resources inspired the development of the User Controlled Lightpath Provisioning System (UCLP). The UCLP version 2 (UCLPv2) is based on a service-oriented architecture in which network resources are abstracted as and managed via Web Services. It introduces a new concept, called Articulated Private Network, where end-users collect resources from several different domains to dynamically articulate and change their network topology. In the current UCLPv2 system, the process of resource sharing is manual, usually error prone and inefficient. This thesis proposes, designs and implements a new functionality for resource advertising and discovery as an enhancement to the UCPv2 system. The new functionality describes the UCLPv2 resources based on the Resource Description Framework (RDF) and advertises them in directories. This allows automation of the resource advertising and discovery. By adopting RDF, the capability of sharing resources with other provisioning applications is achieved.
Udoy M. Ghose: Die Transformation der Indischen Union. Eine empirische und theoretische Analyse der Wirtschaftsreformen 1991-96 und ihrer Implikationen fur die Mainstream Transformationstheorie
Creators: name: Zingel, Wolfgang-Peter
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 92 (2004): ASIEN (Juli)
Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells
Creators: name: Godoy, Patricio
name: Schmidt-Heck, Wolfgang
name: Natarajan, Karthick
name: Lucendo-Villarin, Baltasar
name: Szkolnicka, Dagmara
name: Asplund, Annika
name: Björquist, Petter
name: Widera, Agata
name: Stöber, Regina
name: Campos, Gisela
name: Hammad, Seddik
name: Sachinidis, Agapios
name: Chaudhari, Umesh
name: Damm, Georg
name: Weiss, Thomas S.
name: Nüssler, Andreas
name: Synnergren, Jane
name: Edlund, Karolina
name: Küppers-Munther, Barbara
name: Hay, David C.
name: Hengstler, Jan G.
Publisher: name: Universität Regensburg
Year: 2015
Subjects: subject: Stem cells Hepatocytes Differentiation Gene array Bioinformatics Transcriptomics Gene networks
subject: 610 Medizin

description: Background & Aims

The differentiation of stem cells to hepatocyte-like cells (HLC) offers the perspective of unlimited supply of human hepatocytes. However, the degree of differentiation of HLC remains controversial. To obtain an unbiased characterization, we performed a transcriptomic study with HLC derived from human embryonic and induced stem cells (ESC, hiPSC) from three different laboratories.
Methods

Genome-wide gene expression profiles of ESC and HLC were compared to freshly isolated and up to 14 days cultivated primary human hepatocytes. Gene networks representing successful and failed hepatocyte differentiation, and the transcription factors involved in their regulation were identified.
Results

Gene regulatory network analysis demonstrated that HLC represent a mixed cell type with features of liver, intestine, fibroblast and stem cells. The “unwanted” intestinal features were associated with KLF5 and CDX2 transcriptional networks. Cluster analysis identified highly correlated groups of genes associated with mature liver functions (n = 1057) and downregulated proliferation associated genes (n = 1562) that approach levels of primary hepatocytes. However, three further clusters containing 447, 101, and 505 genes failed to reach levels of hepatocytes. Key TF of two of these clusters include SOX11, FOXQ1, and YBX3. The third unsuccessful cluster, controlled by HNF1, CAR, FXR, and PXR, strongly overlaps with genes repressed in cultivated hepatocytes compared to freshly isolated hepatocytes, suggesting that current in vitro conditions lack stimuli required to maintain gene expression in hepatocytes, which consequently also explains a corresponding deficiency of HLC.
Conclusions

The present gene regulatory network approach identifies key transcription factors which require modulation to improve HLC differentiation.
Studies of Iron Polyfluorometallacycle Complexes Enroute to the "Green" Catalytic Synthesis of Hydrofluorocarbons
Creators: name: Granville, Stephanie L
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: subject: Chemistry, Inorganic.
subject: Chemistry, Organic.

description: Chlorofluorocarbons were once commonly used as propellants and refrigerants due to their stability, low toxicity and excellent physical properties. They were phased out, however, after being identified as ozone-depleters, and have been replaced by hydrofluorocarbons (HFCs) and other fluorocarbon derivatives (FCDs). The high temperature-resistant characteristic of these materials is beneficial for many applications; however, the robust nature of the C-F bonds leads to their persistence in the environment. Frequently, the synthesis of HFCs and FCDs involves energy-intensive processes and toxic precursors, such as chlorocarbons and heavy metals. In accordance with the shift to greener, more sustainable chemistry, more energy efficient methods employing less hazardous and non-toxic materials for the generation of HFCs and FCDs need to be developed. Organometallic catalysis offers potential new routes to the synthesis of fluorinated compounds. We sought to study the reactivity of tetrafluoroethylene and 1,1-difluoroethylene with a variety of iron complexes to increase our understanding of the bonding and chemistry of coordinated fluoro-olefins. Crystal structures were obtained for the parent and dppe substituted metallaycles: Fe(CF2) 4(CO)4 and Fe(CF2)4(K2-dppe)(CO) 2. Sterics were found to be responsible for the preferential formation of three- versus five-membered metallacycles through investigating the reactivity of TFE with iron phosphine- and phosphite-carbonyl complexes, as well as with the homoleptic complex pentakis(2,6-dimethylphenylisocyanide)iron and the anionic complex K[FeCp(CO)2]. The five-membered metallacycle was selectively formed with the mono-substituted phosphine and phosphite complexes, whereas, the di-substituted complexes yield the olefin (three-membered metallacycle) complexes. With the goal of developing methods for iron-mediated fluoride abstraction, the reactivity of these iron fluoro-metallacycles with a variety of Lewis acids was probed. Extremely electrophillic fluoro-carbenes were generated. A more electron rich metal centre, as in the thermally synthesized K[FeCp(CF 2)4(CO)2], is required to facilitate fluoride abstraction and stabilize the fluor-ocarbene. The results that were obtained in this investigation set the stage well for further development of iron-based organofluorometallic chemistry and our desire to functionalize the alpha-carbon of the metallacycle enroute to the generation of novel FCs.
Supplemental_file_3
Creators: name: Ferraro, Salvatore
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 309999
subject: Other agricultural, veterinary and food sciences not elsewhere classified

description: Assessment of the model fit made for the study published by Ferraro et al. paper Dairy farm management factors associated with auction sale price of young dairy calves sold at auction markets in Québec, Canada. A cross-sectional studyFigure 1. Studentized residuals (y axis) versus leverage plot (x axis) from the final multivariable linear regression model built to explore the possible associations between farms’ characteristics, calves’ management practices and median percentile of surplus calves’ selling price per farm.Figure 2. Distribution of Cook’s distances from the final multivariable regression model exploring the possible associations between farms’ characteristics, calves’ management practices and median percentile of surplus calves’ selling price per farm.
Do women spend longer on wait lists for coronary bypass surgery? Analysis of a population-based registry in British Columbia, Canada
Creators: name: Levy, Adrian R.
name: Sobolev, Boris
name: Kuramoto, Lisa
name: Hayden, Robert
name: MacLeod, Stuart M.
Publisher: name: BioMed Central
Year: 2015

description: Background: Studies have shown patients who are delayed for surgical cardiac revascularization are faced with increased risks of symptom deterioration and death. This could explain the observation that operative mortality among persons undergoing coronary artery bypass surgery (CABG) is higher among women than men. However, in jurisdictions that employ priority wait lists to manage access to elective cardiac surgery, there is little information on whether women wait longer than men for CABG. It is therefore difficult to ascertain whether higher operative mortality among women is due to biological differences or to delayed access to elective CABG. Methods Using records from a population-based registry, we compared the wait-list time between women and men in British Columbia (BC) between 1990 and 2000. We compared the number of weeks from registration to surgery for equal proportions of women and men, after adjusting for priority, comorbidity and age. Results In BC in the 1990s, 9,167 patients aged 40 years and over were registered on wait lists for CABG and spent a total of 136,071 person-weeks waiting. At the time of registration for CABG, women were more likely to have a comorbid condition than men. We found little evidence to suggest that women waited longer than men for CABG after registration, after adjusting for comorbidity and age, either overall or within three priority groups. Conclusion Our findings support the hypothesis that higher operative mortality during elective CABG operations observed among women is not due to longer delays for the procedure.
EKSPERIMENTAL PSIXOLOGIYA, UNING RIVOJLANISH JARAYONLARI
Creators: name: Baxtiyorova, Umida
Publisher: name: Zenodo
Year: 2024

description: ushbu maqolada eksperimental psixologiya, uning rivojlanish jarayonlari, bosqichlari, eksperimental psixologiyaning tamoyillari, tamoyillarning mazmuni va foydalanilishi, psixik hodisalarni o‘lchashning mumkinligi, psixologiyada eksperimetning bo‘lishi mumkinligi haqidagi psixolog olimlarning qarashlari, eksperimental psixologiyaning inson psixikasini tushunishda va odamlarga yordam berishdagi samaradorligi haqida fikrlar bayon etilgan.
Ginsenoside variation and phytochemistry of Ontario-grown North American ginseng (Panax quinquefolius): Assessing land race diversity and biological activities
Creators: name: McIntyre, Kristina L
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: subject: Biology, Botany.
subject: Biology, Plant Physiology.

description: North American ginseng (Panax quinquefolius L.) is a valuable and widely used medicinal plant and Ontario has become the largest grower of ginseng in North America. Ginseng has been grown in Ontario for over 50 years and has reached the land race stage. The phytochemistry of Ontario ginseng land races was characterized using high performance liquid chromatography (HPLC) coupled with a diode array detector (DAD), evaporative light scattering detector (ELSD), or mass spectrometry (MS) to assess ginsenoside and monosaccharide content. Nuclear magnetic resonance (NMR) was used successfully as a metabolomic tool to distinguish Ontario ginseng land races and ginseng species. Ginsenoside variation was high within and among Ontario ginseng land races and variation in ginsenoside content was correlated positively to the level of inhibition of the drug metabolizing cytochrome P450 enzyme, CYP3A4. Along with the assessment of ginsenosides, LC/MS/MS and LC/ELSD methods were developed to characterize malonyl ginsenosides and monosaccharide components respectively in Ontario ginseng. Malonyl ginsenosides accounted for a significant percentage of total ginsenoside content and glucose was found to be the major monosaccharide component. Although chromatographic ginsenoside analysis did not differentiate land races, 1H NMR was successfully applied to distinguish ginseng species and two of five land races. The results from this study contribute to the validation and characterization of Ontario ginseng and add to the value of this important medicinal crop.
A controlled trial of the Litebook light-emitting diode (LED) light therapy device for treatment of Seasonal Affective Disorder (SAD)
Creators: name: Desan, Paul H.
name: Weinstein, Andrea J.
name: Michalak, Erin E.
name: Tam, Edwin M.
name: Meesters, Ybe
name: Ruiter, Martine J.
name: Horn, Edward
name: Telner, John
name: Iskandar, Hani
name: Boivin, Diane B.
name: Lam, Raymond W.
Publisher: name: BioMed Central
Year: 2015

description: Background: Recent research has emphasized that the human circadian rhythm system is differentially sensitive to short wavelength light. Light treatment devices using efficient light-emitting diodes (LEDs) whose output is relatively concentrated in short wavelengths may enable a more convenient effective therapy for Seasonal Affective Disorder (SAD). Methods The efficacy of a LED light therapy device in the treatment of SAD was tested in a randomized, double-blind, placebo-controlled, multi-center trial. Participants aged 18 to 65 with SAD (DSM-IV major depression with seasonal pattern) were seen at Baseline and Randomization visits separated by 1 week, and after 1, 2, 3 and 4 weeks of treatment. Hamilton Depression Rating Scale scores (SIGH-SAD) were obtained at each visit. Participants with SIGH-SAD of 20 or greater at Baseline and Randomization visits were randomized to active or control treatment: exposure to the Litebook LED treatment device (The Litebook Company Ltd., Alberta, Canada) which delivers 1,350 lux white light (with spectral emission peaks at 464 nm and 564 nm) at a distance of 20 inches or to an inactivated negative ion generator at a distance of 20 inches, for 30 minutes a day upon awakening and prior to 8 A.M. Results Of the 26 participants randomized, 23 completed the trial. Mean group SIGH-SAD scores did not differ significantly at randomization. At trial end, the proportions of participants in remission (SIGH-SAD less than 9) were significantly greater (Fisher's exact test), and SIGH-SAD scores, as percent individual score at randomization, were significantly lower (t-test), with active treatment than with control, both in an intent-to-treat analysis and an observed cases analysis. A longitudinal repeated measures ANOVA analysis of SIGH-SAD scores also indicated a significant interaction of time and treatment, showing superiority of the Litebook over the placebo condition. Conclusion The results of this pilot study support the hypothesis that light therapy with the Litebook is an effective treatment for SAD. Trial registration Clinicaltrials.gov: NCT00139997
What is known about optimal care pathways and the timeliness of care in patients with colorectal cancer in Australia?
Creators: name: Fox, Elliott
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 420311
subject: Health systems

description: This scoping review aims to determine what is currently known about the Optimal care pathway for people with colorectal cancer and how it is implemented in the delivery of care to patients in Australia.
title: Understanding Elite Politics Through Relentless Research: Warren Sun’s Hua Guofeng Nianpu, Chronology of Hua Guofeng (1971–1981)
Creators: name: Teiwes, Frederick C.
Publisher: name: University of Sydney
publisherIdentifier: https://ror.org/0384j8v12
publisherIdentifierScheme: ROR
Year: 2024
Subjects: Chinese politics

description: This Working Paper is a pre-publication review of an immense documentary collection prepared over the past 25 years by Warren Sun, Adjunct Associate Professor at Monash University and Affiliate Member of the Sydney CSC. It is based on the intellectual premise that elite politics in the CCP cannot be understood without deep penetration into the details of political decision-making and conflict. In its absence, simplistic narratives emerge and become widely accepted, especially when the Party itself is creating the basis for the narrative. This is most prevalent for the immediate post-Mao period as a Hua Guofeng-Deng Xiaoping struggle between different ideological lines and in the profound misunderstanding of Hua as a limited, merely transitional political leader. Hua nianpu uses a wide range of sources to uncover details that contest such views. These include: the contemporary PRC public record; official documentary collections; internal Party documents including unpublished speeches and compendia of circulars at major Party meetings; memoirs, oral accounts, and recollections published in the PRC by or about leaders; studies by Party history scholars in PRC journals; more-adventurous books published in Hong Kong by Party historians and former officials; interviews with scholars and retired officials; and unique interviews with officials who worked as secretaries or as aides to very senior figures and their family members, especially members of Hua’s family. However, these sources have limitations that must be considered critically and discussed in terms of what they can and cannot provide. Taken together the detailed information compiled in Hua nianpu undermines central features of the accepted narrative, most notably by showing that the 1978 work conference and the subsequent Third Plenum were joint Hua-Deng ventures to advance modernization, and when unanticipated developments weakened Hua, Deng did not act against him. Instead, he worked to lower tensions and to return the focus to their original joint plan. Hua nianpu is a major basis for our joint book project, Hua Guofeng, Deng Xiaoping, and the Dismantling of Maoism. But this nianpu is entirely Professor Sun’s creation and exacting work. The target for submission of both these projects to their respective publishers is early 2025.
Exergy Minimization in Ethanol Dehydration using Hybrid DistillationMembrane Systems
Creators: name: Yuan, Jie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: subject: Chemistry, Organic.

description: As a renewable energy source, bioethanol is widely used for blending in gasoline in an attempt to partly alleviate the energy crisis and reduce the greenhouse gas emissions. To produce fuel grade ethanol, the dehydration process of bioethanol is a critical step for the economic viability of the whole process. With a single distillation column it is not possible to overcome the azeotropic point of the ethanol/water mixture. In addition, the distillation process is a very energy intensive and costly process. In this thesis, two major topics concerning the dehydration process of bioethanol are discussed. First, the multiple objective optimization of the fuel grade bioethanol dehydration is performed along with a parametric analysis of A-type zeolite membrane pervaporation. Three cases were investigated using the ranked Pareto domain that was obtained in each case. The optimal results were identified as attractive compromised solutions considering the four objectives: the total number of stages, the total area, the energy consumed, and the exergy loss. The temperature drop per stage was found to be the dominating factor. The second theme is the exergy loss minimization of the pervaporation/distillation hybrid system at the tangent pinch on the vapor-liquid equilibrium curve. Results show that both the exergy loss and the reflux ratio of the hybrid system are reduced compared to a single distillation column. In addition, the exergy loss of the hybrid system is correlated with the variation of the reflux ratio.
V-XI ASRLARDA YEVROPADA PSIXOLOGIYANING RIVOJLANISHI
Creators: name: Baxtiyorova, Umida
Publisher: name: Zenodo
Year: 2024

description: maqolada psixologiya tarixi, uning ruh haqidagi falsafiy mulohazalardan aqliy jarayonlar va inson xulq-atvori bo'yicha zamonaviy ilmiy izlanishlarga qadar bo'lgan taraqqiyoti, psixologiya rivojlanishining asosiy bosqichlari, psixologiyaning rivojlanish xususiyatlari, Kognitiv psixologiya, zamonaviy psixologiyagacha bo‘lgan jarayonlar mazmuni ilmiy asoslangan holda bayon etilgan.
Gemeinsame Tagung: Deutsche Gesellschaft für Völkerkunde, Österreichische Ethnologische Gesellschaft, Anthropologische Gesellschaft in Wien, Berliner Gesellschaft für Anthropologie, Ethnologie und Urgeschichte
Creators: name: Redaktion, Die
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 50 (1994): ASIEN (Januar)
ParsText
Creators: name: Tang, Kevin
name: Merchant, Rayyan
Publisher: name: OSF
Year: 2024

description: Despite speaking dialects of the same language, Persian speakers from Tajikistan cannot read Persian texts from Iran and Afghanistan. This is due to the fact that Tajik Persian is written in the Tajik-Cyrillic script, while Iranian and Afghan Persian are written in the Perso-Arabic script. As the formal registers of these dialects all maintain high levels of mutual intelligibility with each other, machine transliteration has been proposed as a more practical and appropriate solution than machine translation. Unfortunately, Persian texts written in both scripts are much more common in print in Tajikistan than online. This paper introduces a novel corpus meant to remedy that gap: ParsText. ParsText contains 2,813 Persian sentences written in both Tajik-Cyrillic and Perso-Arabic manually collected from blog pages and news articles online.