cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
[Nordmaniana geg. Kirche]
Creators: name: Breitinger, Robert
Publisher: name: [Robert Breitinger]
Year: 1901
Subjects: Nordmannstanne

description: Häuser an der Bürglistrasse 19 (Pfarrhaus) und 17, und ganz rechts Schulhausstrasse 16, im Hintergrund Kirche Enge
description: [Robert Breitinger]
description: Bildtitel gemäss Zettelkatalog der Graphischen Sammlung und des Fotoarchivs und dem Verzeichnis Breitingers
description: Gemäss dem Verzeichnis Breitingers wurde die Fotografie am 19. Januar 1901 um 10.30 Uhr aufgenommen. Im Verzeichnis Information zu den Wetterverhältnissen "Nebel heller"
description: Aus der Sammlung Breitinger (1841-1913) Exemplar der Zentralbibliothek Zürich, Graphische Sammlung und Fotoarchiv
description: Auf der Rückseite handschriftliche Notizen und oben rechts Vermerk mit Bleistift: "6207" (Bildnummer der Kabinettkarte) Exemplar der Zentralbibliothek Zürich, Graphische Sammlung und Fotoarchiv
title: SFTA2 - a novel secretory peptide highly expressed in the lung - is modulated by lipopolysaccharide but not hyperoxia
Creators: name: Mittal, Rashmi A.
name: Hammel, Markus
name: Schwarz, Johannes
name: Heschl, Katharina M.
name: Bretschneider, Nancy
name: Flemmer, Andreas W.
name: Herber-Jonat, Susanne
name: Königshoff, Melanie
name: Eickelberg, Oliver
name: Holzinger, Andreas
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2012
Subjects: subject: 610

description: Tissue-specific transcripts are likely to be of importance for the corresponding organ. While attempting to define the specific transcriptome of the human lung, we identified the transcript of a yet uncharacterized protein, SFTA2. In silico analyses, biochemical methods, fluorescence imaging and animal challenge experiments were employed to characterize SFTA2. Human SFTA2 is located on Chr. 6p21.33, a disease-susceptibility locus for diffuse panbronchiolitis. RT-PCR verified the abundance of SFTA2-specific transcripts in human and mouse lung. SFTA2 is synthesized as a hydrophilic precursor releasing a 59 amino acid mature peptide after cleavage of an N-terminal secretory signal. SFTA2 has no recognizable homology to other proteins while orthologues are present in all mammals. SFTA2 is a glycosylated protein and specifically expressed in nonciliated bronchiolar epithelium and type II pneumocytes. In accordance with other hydrophilic surfactant proteins, SFTA2 did not colocalize with lamellar bodies but colocalized with golgin97 and clathrin-labelled vesicles, suggesting a classical secretory pathway for its expression and secretion. In the mouse lung, Sfta2 was significantly downregulated after induction of an inflammatory reaction by intratracheal lipopolysaccharides paralleling surfactant proteins B and C but not D. Hyperoxia, however, did not alter SFTA2 mRNA levels. We have characterized SFTA2 and present it as a novel unique secretory peptide highly expressed in the lung.
Exhaustion Land Experiment overview figure
Creators: name: Rothamsted Research
Publisher: name: Rothamsted Experimental Station
Year: 2016
Subjects: subject: potatoes
valueUri: c_13551
subject: precipitation
valueUri: c_6161
subject: rainfall patterns
valueUri: c_34890
subject: ecological succession
valueUri: c_2464

description: Figure illustrating the main treatment phases for the Exhaustion Land Long-term experiment
Exhaustion Land Experiment plans and fertilizer treatments, Phase IV, 1986-2006
Creators: name: Glendining, Margaret
name: Poulton, Paul
Publisher: name: Rothamsted Experimental Station
Year: 2022
Subjects: subject: Exhaustion land long-term experiment
valueUri: Q41528375
subject: fertilizer
valueUri: c_2867
subject: residual effects
valueUri: c_24408
subject: Rothamsted Research
valueUri: Q1326711
subject: phosphorous
valueUri: c_5804
subject: potassium
valueUri: c_6139

description: Plans and details of the fertilizer treatments applied to the Rothamsted Exhaustion Land Experiment, Phase IV (1986-2006), not to scale.
title: Transcript-specific expression profiles derived from sequence-based analysis of standard microarrays.
Creators: name: Moll, Anton G.
name: Lindenmeyer, Maja T.
name: Kretzler, Matthias
name: Nelson, Peter J.
name: Zimmer, Ralf
name: Cohen, Clemens D.
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2009
Subjects: subject: 610

description: Alternative mRNA processing mechanisms lead to multiple transcripts (i.e. splice isoforms) of a given gene which may have distinct biological functions. Microarrays like Affymetrix GeneChips measure mRNA expression of genes using sets of nucleotide probes. Until recently probe sets were not designed for transcript specificity. Nevertheless, the re-analysis of established microarray data using newly defined transcript-specific probe sets may provide information about expression levels of specific transcripts.In the present study alignment of probe sequences of the Affymetrix microarray HG-U133A with Ensembl transcript sequences was performed to define transcript-specific probe sets. Out of a total of 247,965 perfect match probes, 95,008 were designated "transcript-specific", i.e. showing complete sequence alignment, no cross-hybridization, and transcript-, not only gene-specificity. These probes were grouped into 7,941 transcript-specific probe sets and 15,619 gene-specific probe sets, respectively. The former were used to differentiate 445 alternative transcripts of 215 genes. For selected transcripts, predicted by this analysis to be differentially expressed in the human kidney, confirmatory real-time RT-PCR experiments were performed. First, the expression of two specific transcripts of the genes PPM1A (PP2CA_HUMAN and P35813) and PLG (PLMN_HUMAN and Q5TEH5) in human kidneys was determined by the transcript-specific array analysis and confirmed by real-time RT-PCR. Secondly, disease-specific differential expression of single transcripts of PLG and ABCA1 (ABCA1_HUMAN and Q5VYS0_HUMAN) was computed from the available array data sets and confirmed by transcript-specific real-time RT-PCR.Transcript-specific analysis of microarray experiments can be employed to study gene-regulation on the transcript level using conventional microarray data. In this study, predictions based on sufficient probe set size and fold-change are confirmed by independent means.
[Fichte mit Haus]
Creators: name: Breitinger, Robert
Publisher: name: [Robert Breitinger]
Year: 1901
Subjects: Fichte

description: Schulhausstrasse 18
description: [Robert Breitinger]
description: Bildtitel gemäss Zettelkatalog der Graphischen Sammlung und des Fotoarchivs und dem Verzeichnis Breitingers
description: Gemäss dem Verzeichnis Breitingers wurde die Fotografie am 19. Januar 1901 um 10.30 Uhr aufgenommen. Im Verzeichnis Information zu den Wetterverhältnissen "Nebel heller"
description: Aus der Sammlung Breitinger (1841-1913) Exemplar der Zentralbibliothek Zürich, Graphische Sammlung und Fotoarchiv
description: Auf der Rückseite handschriftliche Notizen und oben rechts Vermerk mit Bleistift: "6208" (Bildnummer der Kabinettkarte) Exemplar der Zentralbibliothek Zürich, Graphische Sammlung und Fotoarchiv
Validating the ratio of insulin like growth factor binding protein 4 to sex hormone binding globulin as a prognostic predictor of preterm birth in Viet Nam: a case-cohort study
Creators: name: Hirst, Jane E.
name: Boniface, J. Jay
name: Le, Dung Puhong
name: Polpitiya, Ashoka D.
name: Fox, Angela C.
name: Vu, Thi Thai Kim
name: Dang, Thuan Trong
name: Fleischer, Tracey C.
name: Bui, Nhu Thi Hong
name: Hickok, Durlin E.
name: Kearney, Paul E.
name: Thwaites, Guy
name: Kennedy, Stephen H.
name: Kestelyn, Evelyne
name: Le, Thanh Quang
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer
subject: Hematology
subject: Computational Biology

description: To validate a serum biomarker developed in the USA for preterm birth (PTB) risk stratification in Viet Nam. Women with singleton pregnancies (n = 5000) were recruited between 19+0-23+6 weeks’ gestation at Tu Du Hospital, Ho Chi Minh City. Maternal serum was collected from 19+0-22+6 weeks’ gestation and participants followed to neonatal discharge. Relative insulin-like growth factor binding protein 4 (IGFBP4) and sex hormone binding globulin (SHBG) abundances were measured by mass spectrometry and their ratio compared between PTB cases and term controls. Discrimination (area under the receiver operating characteristic curve, AUC) and calibration for PTB <37 and <34 weeks’ gestation were tested, with model tuning using clinical factors. Measured outcomes included all PTBs (any birth ≤37 weeks’ gestation) and spontaneous PTBs (birth ≤37 weeks’ gestation with clinical signs of initiation of parturition). Complete data were available for 4984 (99.7%) individuals. The cohort PTB rate was 6.7% (n = 335). We observed an inverse association between the IGFBP4/SHBG ratio and gestational age at birth (p = 0.017; AUC 0.60 [95% CI, 0.53-0.68]). Including previous PTB (for multiparous women) or prior miscarriage (for primiparous women) improved performance (AUC 0.65 and 0.70, respectively, for PTB <37 and <34 weeks’ gestation). Optimal performance (AUC 0.74) was seen within 19-20 weeks’ gestation, for BMI >21 kg/m2 and age 20-35 years. We have validated a novel serum biomarker for PTB risk stratification in a very different setting to the original study. Further research is required to determine appropriate ratio thresholds based on the prevalence of risk factors and the availability of resources and preventative therapies.
title: Heat-shock mediated overexpression of HNF1Î² mutations has differential effects on gene expression in the Xenopus pronephric kidney.
Creators: name: Sauert, Kathrin
name: Kahnert, Stefan
name: Roose, Magdalena
name: Gull, Mazhar
name: Brändli, André W.
name: Ryffel, Gerhart U.
name: Waldner, Christoph
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2012
Subjects: subject: 610

description: The transcription factor HNF1B, encoded by the TCF2 gene, plays an important role in the organogenesis of vertebrates. In humans, heterozygous mutations of HNF1B are associated with several diseases, such as pancreatic Î²-cell dysfunction leading to maturity-onset diabetes of the young (MODY5), defective kidney development, disturbed liver function, pancreas atrophy, and malformations of the genital tract. The African claw frog Xenopus laevis is an excellent model to study the processes involved in embryogenesis and organogenesis, as it can be manipulated easily with a series of methods. In the present study, we overexpressed HNF1Î² mutants in the developing Xenopus embryo to assess their roles during organogenesis, particularly in the developing pronephric kidney. Towards this goal, we developed a heat-shock inducible binary Cre/loxP system with activator and effector strains. Heat-shock activation of the mutant HNF1B variants P328L329del and A263insGG resulted in malformations of various organs and the affected larvae developed large edemas. Defects in the pronephros were primarily confined to malformed proximal tubules. Furthermore, the expression of the proximal tubule marker genes tmem27 and slc3a1, both involved in amino acid transport, was affected. Both P328L329del and A263insGG downregulated expression of slc3a1. In addition, P328L329del reduced tmem27 expression while A263insGG overexpression decreased expression of the chloride channel clcnk and the transcription factor pax2. Overexpression of two mutant HNF1B derivatives resulted in distinct phenotypes reflected by either a reduction or an enlargement of pronephros size. The expression of selected pronephric marker genes was differentially affected upon overexpression of HNF1B mutations. Based on our findings, we postulate that HNF1B mutations influence gene regulation upon overexpression in specific and distinct manners. Furthermore, our study demonstrates that the newly established Cre/loxP system for Xenopus embryos is an attractive alternative to examine the gene regulatory potential of transcription factors in developing pronephric kidney as exemplified here for HNF1B.
Grüebler Bleicherweg
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1893
Subjects: Restaurant
Zürich

description: Anonyme/r Fotograf/in
description: Ehemaliges Gebäude der Wirtschaft zum Grübel am Bleicherweg (damaliger Standort entspricht etwa der heutigen Hausnummer 56)
Neonatal transport: parental needs and potential for improvement – a single-center cross-sectional study
Creators: name: Lengauer, Charlotte
name: Grass, Beate
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Neonates with medical problems need transfer from the place of birth to a neonatal (intensive care) unit after birth by a specialized neonatal transport team. Neonatal transport is accompanied by a high emotional burden for the families due to spatial separation, uncertainty and care for the neonate. This survey of parents’ needs was a quality control project of the neonatal transport team of the University Children’s Hospital Zurich, Switzerland. The aim was to identify areas for improvement of family-centred care and to derive concrete suggestions for adjustments in the transport process. This single-center prospective cross-sectional study included parents of neonates transported between January 2021 and February 2022. Based on a literature review, an anonymous questionnaire was developed (mini-Delphi method) and conducted using an online survey tool. The survey results were analyzed descriptively. The response rate was 77% (168/217). The majority of parents agreed with the current procedures for neonatal transports and experienced the transport team as professional. There were no (emotional) support measures applied by the transport team which were not approved by the parents. Some parents suggested the following additions: the possibility of parental accompaniment during transport, contact by telephone on arrival at the destination hospital, and an improvement in the transmission of medical information, both prenatally and in the context of transport. There is potential for improvement in meeting parental needs during neonatal transport. Some parental suggestions can be implemented easily and cost-effectively. The importance of professional communication and situationally adapted information for parents was confirmed.
title: Zwischen Romantik und Realismus - Geschlechterverhältnisse in Briefromanen Mitte des 19. Jahrhunderts
Creators: name: Gasch, Karin
Year: 2013

description: Die Gattung Briefroman wird auf ihre Bedeutung für die schriftstellerische Produktion von Frauen Mitte des 19. Jahrhunderts in Deutschland und England hin untersucht. Ein besonderer Augenmerk gilt dabei den literaturhistorischen und sozialgeschichtlichen Rahmenbedingungen denen die Autorinnen zu dieser Zeit ausgesetzt waren. Der Hauptteil der Arbeit beschäftigt sich mit den beiden Briefromanen von Bettine von Arnim und Anne Brontë, wobei diese im Hinblick auf die darin abgebildeten Geschlechterverhältnisse untersucht, miteinander verglichen und sowohl mit den zeitgenössischen als auch mit gegenwärtigen Diskursen zur weiblichen Autorschaft kontextualisiert werden.
[Restaurant Grüebler und Wohnhaus am Bleicherweg]
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1893
Subjects: Restaurant
Zürich

description: Anonyme/r Fotograf/in
description: Ehemalige Gebäude am Bleicherweg: Wirtschaft zum Grübel, Scheune und Wohnhaus bei Nummer 48 (damaliger Standort entspricht etwa der heutigen Hausnummern 52-56)
Hoosfield spring barley experiment plans 1968-2000
Creators: name: Rothamsted Research
Publisher: name: Rothamsted Experimental Station
Year: 2015
Subjects: subject: fertilizer
valueUri: c_2867
subject: farmyard manure
valueUri: c_2810
subject: Rothamsted Research
valueUri: Q1326711
subject: Hoosfield spring barley long-term experiment
valueUri: Q41522609
subject: long term experiments
valueUri: C5355
subject: experimental design
valueUri: c_29466
subject: barley
valueUri: c_823

description: Standardised experiment plans for the Hoosfield spring barley experiment, 1968-2000, with details of fertilizer and manure treatments (not to scale). Includes rotation of potatoes, beans and barley (1968-1978) and silicate treatments (1979-2000).
description: Derived from plans published in the Rothamsted Guides to the Classical and Field Experiments, 1977 and 1991. None None
Sonnenfleckenzeichnung Nr. 1262.
Zeichnung von Flecken und Fackelflächen zur Ermittlung der Sonnenaktivität am 13.10.1892, erstellt von Alfred Wolfer
Creators: name: Eidgenössische Sternwarte in Zürich (ETH Zürich bzw. vor 1911 Polytechnikum)
Publisher: name: [s.n.]
Year: 1892

description: Bleistiftzeichnung mit Tinte und Farbstift überschrieben, erstellt als Projektionsbildzeichnung in der Eidgenössischen Sternwarte Zürich. Instrument: Kern-Merz-Refraktor.
Die Beobachtungen zu Einzelflecken und zu Sonnenfleckengruppen wurden mit Bleistift auf einem Vordruck eingetragen. Zugeordnete numerische Werte wurden in einer separat geführten, chronologischen Tabelle erfasst. Unter Umständen sind tabellarisch notierte Werte, die für Protuberanzen mit rot geschrieben wurden, direkt auf der Fleckenzeichnung vermerkt
description: ETH-Bibliothek
title: Individuation bei Ibn Sīnā
Creators: name: Rogers, Christoph
Year: 2013

description: Die vorliegende Arbeit setzt sich mit Ibn Sīnās Konzeptionen des Individuationsprozesses anhand seiner Ausführungen in der Metaphysik (Ilāhīyāt) des Kitāb aš-Šifāʾ, sowie der Abhandlung über die Seele innerhalb des Werks an-Naǧāt auseinander. Der Schwerpunkt der Untersuchung liegt bei der Erörterung des Zusammenhangs zwischen transkategorialen Begriffen und der von Ibn Sīnā beschriebenen Emanation. In der wissenschaftlichen Literatur wird zu meist der kausale Zusammenhang von Intellekt, Seele und Körper dargelegt, ohne auf die von Ibn Sīnā aufgestellten Möglichkeitsbedingungen sprachlicher Explikation einzugehen. Insofern Begriffe und Vorstellungen hinsichtlich ihrer Entstehung im Verstand Gesetzmäßigkeiten und Modalitäten unterliegen, die von extramentalen Entitäten ebenfalls ausgesagt werden, ist eine Analyse der von Ibn Sīnā beschriebenen Voraussetzungen der Begriffsbildung nötig, um die Möglichkeiten und Grenzen der Denotation im Falle kausaler Zusammenhänge bestimmen zu können. Im ersten Teil der Arbeit steht die Genealogie des aristotelischen Substanzbegriffs in der Spätantike im Zentrum der Untersuchung. Da die Kategorie der Substanz in der aristotelischen Metaphysik die Voraussetzung eines jeden Seinsbezugs darstellt, wird auf Ibn Sīnās Konzeption von Substanz genauer eingegangen, um den Ausgangspunkt der kausalen Relation von Intellekt, Seele und Körper aufgreifen zu können. Im Anschluss daran folgt im zweiten Teil der Arbeit eine Untersuchung transkategorialer Begriffe, welche Ibn Sīnā im ersten Buch seiner Metaphysik vorstellt. Es darf nicht angenommen werden, dass diese Begriffe ausschließlich epistemologische Relevanz besitzen, noch darf davon ausgegangen werden, insofern von Transkategorialität die Rede ist, dass Ibn Sīnā die aristotelische Substanzlehre durch eine Metaphysik ersetzt, in welcher transkategoriale Begriffe eine ontologisch eminente Position vor der Kategorie der Substanz einnehmen. Stattdessen, so die Hauptthese dieser Arbeit, sind sie wesentliche Faktoren der Emanation, insoweit die Explikationsmöglichkeiten des Verstandes in einem analogen Verhältnis zu den Möglichkeiten von Ereignissen in der extramentalen Welt stehen, da beide Ebenen letztlich in einem seelischen Prinzip gründen. Der dritte Teil befasst sich sodann mit den Eigenschaften von Intellekt, Seele und Körper und erörtert in welchem Verhältnis sie zu einander stehen. Der Seelenbegriff rückt als vermittelndes Prinzip hierbei in den Vordergrund der Untersuchung. Im vierten Teil der Arbeit wird überprüft, auf welche Weise Ibn Sīnā die Enstehung des Kosmos erklärt. Dabei wird argumentiert, dass der Notwendigseiende bzw. Gott für Ibn Sīnā letztlich nicht als Zweckursache aufzufassen ist.
title: MVA-based H5N1 vaccine affords cross-clade protection in mice against influenza A/H5N1 viruses at low doses and after single immunization.
Creators: name: Kreijtz, Joost H. C. M.
name: Suezer, Yasemin
name: Mutsert, Gerrie de
name: Amerongen, Geert van
name: Schwantes, Astrid
name: Brand, Judith M. A. van den
name: Fouchier, Ron A. M.
name: Löwer, Johannes
name: Osterhaus, Albert D. M. E.
name: Sutter, Gerd
name: Rimmelzwaan, Guus F.
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2009
Subjects: subject: 570

description: Human infections with highly pathogenic avian influenza viruses of the H5N1 subtype, frequently reported since 2003, result in high morbidity and mortality. It is feared that these viruses become pandemic, therefore the development of safe and effective vaccines is desirable. MVA-based H5N1 vaccines already proved to be effective when two immunizations with high doses were used. Dose-sparing strategies would increase the number of people that can be vaccinated when the amount of vaccine preparations that can be produced is limited. Furthermore, protective immunity is induced ideally after a single immunization. Therefore the minimal requirements for induction of protective immunity with a MVA-based H5N1 vaccine were assessed in mice. To this end, mice were vaccinated once or twice with descending doses of a recombinant MVA expressing the HA gene of influenza virus A/Vietnam/1194/04. The protective efficacy was determined after challenge infection with the homologous clade 1 virus and a heterologous virus derived from clade 2.1, A/Indonesia/5/05 by assessing weight loss, virus replication and histopathological changes. It was concluded that MVA-based vaccines allowed significant dose-sparing and afford cross-clade protection, also after a single immunization, which are favorable properties for an H5N1 vaccine candidate.
Hoosfield spring barley experiment plan 1852-1967
Creators: name: Rothamsted Research
Publisher: name: Rothamsted Experimental Station
Year: 2012
Subjects: subject: fertilizer
valueUri: c_2867
subject: farmyard manure
valueUri: c_2810
subject: Rothamsted Research
valueUri: Q1326711
subject: Hoosfield spring barley long-term experiment
valueUri: Q41522609
subject: long term experiments
valueUri: C5355
subject: experimental design
valueUri: c_29466
subject: barley
valueUri: c_823

description: Standardised experiment plan for the Hoosfield spring barley experiment, 1852-1967, with details of fertilizer and manure treatments (not to scale).
description: Derived from Rothamsted Experimental Station (1970): Details of the Classical and Long-term Experiments 
up to 1967, pp18-21. None None
[Bäume an d. Schulhausstrasse]
Creators: name: Breitinger, Robert
Publisher: name: [Robert Breitinger]
Year: 1901

description: Vermutlich in der Umgebung zwischen Nr. 18 und Schulhaus Gabler aufgenommen
description: [Robert Breitinger]
description: Bildtitel gemäss Zettelkatalog der Graphischen Sammlung und des Fotoarchivs
description: Abzug in zwei Belichtungsvarianten vorhanden, Signatur der Zentralbibliothek Zürich, Graphische Sammlung und Fotoarchiv: Breitinger, Cabinet IV, Blumen u. Bäume 6210/165/1901
description: Gemäss dem Verzeichnis Breitingers wurde die Fotografie am 19. Januar 1901 um 10.30 Uhr aufgenommen. Im Verzeichnis Information zu den Wetterverhältnissen "Nebel heller"
description: Aus der Sammlung Breitinger (1841-1913) Exemplar der Zentralbibliothek Zürich, Graphische Sammlung und Fotoarchiv
description: Auf der Rückseite oben rechts Vermerk mit Bleistift: "6210" (Bildnummer der Kabinettkarte) Exemplar der Zentralbibliothek Zürich, Graphische Sammlung und Fotoarchiv
title: "Woraus bemerkenswerterweise nichts hervorgeht"
Creators: name: Reisinger, Bernadette
Year: 2013

description: Im Mittelpunkt dieser Arbeit steht die Kritik am Geniebegriff und am Persönlichkeitskult der Moderne, die Edgar Zilsel und Robert Musil in ihren Werken Die Geniereligion (1918) und Der Mann ohne Eigenschaften leisten. Der Geniebegriff als eine der Grundkategorien zur Bestimmung der Ursprünge und Resultate künstlerischen Schaffens in der traditionellen Ästhetik mutiert im Laufe des 19. und in der ersten Hälfte des 20. Jahrhunderts zu einer Genie- und Persönlichkeitsideologie, die vor allem in den zwanziger und dreißiger Jahren von jenen Intellektuellen vertreten wird, die Armin Mohler unter den Sammelbegriff der „kulturellen Revolution“ gefasst hat und die sich durch eine antiegalitäre, antidemokratische und aufklärungskritische Gesinnung auszeichnen. Der Philosoph und Wissenschaftstheoretiker Edgar Zilsel, als Vertreter der „wissenschaftlichen Weltauffassung“ Anhänger einer gegenläufigen weltanschaulichen Strömung, und Robert Musil, der ideologisch noch immer schwer zuzuordnen ist, wagen mit ihrer Verhandlung des modernen Geniebegriffs also einen Schritt in das ideologische Mienenfeld, das die Geistesverfassung der Intellektuellen in der Zeit nach dem Ersten Weltkrieg darstellt. In dieser Arbeit geht es darum, die Positionen der beiden Autoren, ihre kritische Partizipation am Geniediskurs und ihre über die „bloße“ Kritik hinausgehenden Problemlösungsansätze zu einer Überwindung der ideellen „Krise“ vor allem anhand einer genauen Textlektüre nachzuzeichnen. Ob aus dem Geniebegriff der Moderne, ob aus den hier verhandelten Texten und ob schließlich aus dem Experiment, ein vergleichsweise unvergleichbares Autorenpaar wie Zilsel und Musil im Zuge einer Arbeit gegenüberzustellen, im Endeffekt etwas oder vielmehr doch „bemerkenswerterweise nichts hervorgeht“, bleibt eine spannende Frage.
title: Single-channel electrophysiology reveals a distinct and uniform pore complex formed by Î±-synuclein oligomers in lipid membranes.
Creators: name: Schmidt, Felix
name: Levin, Johannes
name: Kamp, Frits
name: Kretzschmar, Hans
name: Giese, Armin
name: Bötzel, Kai
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2012
Subjects: subject: 610

description: Synucleinopathies such as Parkinson's disease, multiple system atrophy and dementia with Lewy bodies are characterized by deposition of aggregated Î±-synuclein. Recent findings indicate that pathological oligomers rather than fibrillar aggregates may represent the main toxic protein species. It has been shown that Î±-synuclein oligomers can increase the conductance of lipid bilayers and, in cell-culture, lead to calcium dyshomeostasis and cell death. In this study, employing a setup for single-channel electrophysiology, we found that addition of iron-induced Î±-synuclein oligomers resulted in quantized and stepwise increases in bilayer conductance indicating insertion of distinct transmembrane pores. These pores switched between open and closed states depending on clamped voltage revealing a single-pore conductance comparable to that of bacterial porins. Pore conductance was dependent on transmembrane potential and the available cation. The pores stably inserted into the bilayer and could not be removed by buffer exchange. Pore formation could be inhibited by co-incubation with the aggregation inhibitor baicalein. Our findings indicate that iron-induced Î±-synuclein oligomers can form a uniform and distinct pore species with characteristic electrophysiological properties. Pore formation could be a critical event in the pathogenesis of synucleinopathies and provide a novel structural target for disease-modifying therapy.
title: Dmitri D. Schostakowitsch und der Stalinismus
Creators: name: Petrovic, Gabriela
Year: 2013

description: Meine Arbeit ist in zwei Kapiteln geteilt. Erster Kapitel setzt sich mit dem Diktator Josef Wissarionowitsch Stalin und dem Komponist Dmitri Dmitrijewitsch Schostakowitsch auseinander. Ich schreibe über den grossen Terror in der zweiten Hälfte der 1930er Jahre, besonders über 1936/37. Mein Schwerpunkt hier setzt sich auf Stalins Machtpolitik und auf die Machtpolitik in der Sowjetunion zu dieser Zeit. Ich fasse kurz zusammen, wie die politische Situation, aber auch das kulturelle, und besonders musikalisches, Bild des Alltags in Moskau ausgeschaut hat. Der zweite Kapitel handelt über den 1936 erschienenen Zeitungsartikel “Chaos statt Musik – über die Oper Lady Macbeth von Mzensk“.
Hoosfield spring barley experiment plan 2001 onwards
Creators: name: Rothamsted Research
Publisher: name: Rothamsted Experimental Station
Year: 2009
Subjects: subject: fertilizer
valueUri: c_2867
subject: farmyard manure
valueUri: c_2810
subject: Rothamsted Research
valueUri: Q1326711
subject: Hoosfield spring barley long-term experiment
valueUri: Q41522609
subject: long term experiments
valueUri: C5355
subject: experimental design
valueUri: c_29466
subject: barley
valueUri: c_823

description: Standardised experiment plan for the Hoosfield spring barley experiment, 2001 onwards (not to scale), with details of fertilizer and manure treatments applied since 1968.
description: Dervied from Rothamsted Guide to the Classical and other Long-term experiments, 2006. None None
Comparison of cardiac indices during pregnancy between noninvasive automated device and two-dimensional echocardiography: a longitudinal study
Creators: name: Chaemsaithong, Piya
name: Chung, Man Yan
name: Sun, Qian
name: Kwan, Angel H.W
name: Kubi, Appiah
name: Huang, Junhong
name: Chong, Ka Chun
name: Poon, Liona C.
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology
subject: Cancer

description: To determine the correlation, precision, mean percentage difference and agreement between cardiac indices (stroke volume [SV], cardiac output [CO], SV index [SVI], and cardiac index [CI]) measured by noninvasive cardiac output monitor (NICOM®, Cheetah Medical, Boston, MA, USA) and 2-dimensional transthoracic echocardiography (2D-TTE) across gestations in Chinese pregnant women. This was a prospective longitudinal study performed in women with singleton pregnancy at 11–14+6 (n = 152), 19–24+6 (n = 152), 30–34+6 (n = 141), and 35–37+6 (n = 103). Cardiac indices, including CO and SV, were obtained by NICOM®, which uses thoracic bioreactance, and 2D-TTE. CI and SVI were calculated from CO and SV adjusted for body surface area. The measurements of cardiac indices obtained using NICOM® were assessed relative to that of 2D-TTE by calculating correlation coefficient, bias, precision, mean percentage difference, and 95% limits of agreement, adjusted for repeated measurements. Comparison of the SV and SVI measurements by the two approaches showed significant moderate correlation in the first trimester (r = 0.2–0.3; p = .01). Overall, the SV and SVI measurements obtained using NICOM® relative to that obtained by 2D-TTE revealed a bias of −12.1 mL and −6.1 mL/m2 (95% confidence interval [CI]: −44.5 to 20.2 and −24.8 to 12.5), respectively. Comparison of the CO and CI measurements by the two approaches showed significant moderate correlation in the first trimester (r∼0.2; p = .01). Overall, the CO and CI measurements obtained using NICOM® relative to that obtained by 2D-TTE revealed a bias of −0.50 L/min and −0.18 L/min/m2 (95% CI: 2.26–3.27 and −1.79 to 1.39), respectively. Mean percentage difference for all cardiac parameters in all three trimesters were more than 30%. In Chinese pregnant women, NICOM® has underestimated cardiac indices (SV, CO, SVI, and CI) compared to that measured by 2D-TTE. The mean percentage differences for all cardiac indices are more than 30%, which are higher than the clinically acceptable limit. Future research is needed to determine whether adjustment factors should be applied to the proprietary algorithms used by the NICOM® for the estimation of SV and CO in the Chinese pregnant population.
title: Chitin modulates innate immune responses of keratinocytes.
Creators: name: Koller, Barbara
name: Müller-Wiefel, Alisa Sophie
name: Rupec, Rudolph
name: Korting, Hans Christian
name: Ruzicka, Thomas
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2011
Subjects: subject: 610

description: Chitin, after cellulose the second most abundant polysaccharide in nature, is an essential component of exoskeletons of crabs, shrimps and insects and protects these organisms from harsh conditions in their environment. Unexpectedly, chitin has been found to activate innate immune cells and to elicit murine airway inflammation. The skin represents the outer barrier of the human host defense and is in frequent contact with chitin-bearing organisms, such as house-dust mites or flies. The effects of chitin on keratinocytes, however, are poorly understood.We hypothesized that chitin stimulates keratinocytes and thereby modulates the innate immune response of the skin. Here we show that chitin is bioactive on primary and immortalized keratinocytes by triggering production of pro-inflammatory cytokines and chemokines. Chitin stimulation further induced the expression of the Toll-like receptor (TLR) TLR4 on keratinocytes at mRNA and protein level. Chitin-induced effects were mainly abrogated when TLR2 was blocked, suggesting that TLR2 senses chitin on keratinocytes.We speculate that chitin-bearing organisms modulate the innate immune response towards pathogens by upregulating secretion of cytokines and chemokines and expression of MyD88-associated TLRs, two major components of innate immunity. The clinical relevance of this mechanism remains to be defined.
6. FUNGUS DISEASES OF WHEAT ON BROADBALK, 1843-1967 , Rothamsted Experimental Station Report for 1968 - Part 2
Creators: name: MARY D. GLYNNE
Publisher: name: Lawes Agricultural Trust
Year: 1969
Subjects: subject: rothamsted research
subject: broadbalk long-term experiment
subject: fungal diseases

description: Scanned PDF of 6. FUNGUS DISEASES OF WHEAT ON BROADBALK, 1843-1967 , part of Rothamsted Experimental Station Report for 1968 - Part 2
[Tannengruppe mit Reif]
Creators: name: Breitinger, Robert
Publisher: name: [Robert Breitinger]
Year: 1901
Subjects: Tanne

description: Vom Balkon der Schulhausstrasse 18
description: [Robert Breitinger]
description: Bildtitel gemäss Zettelkatalog der Graphischen Sammlung und des Fotoarchivs
description: Gemäss dem Verzeichnis Breitingers wurde die Fotografie am 23. Februar 1901 aufgenommen. Im Verzeichnis Information zu den Wetterverhältnissen "hell Sonne"
description: Aus der Sammlung Breitinger (1841-1913) Exemplar der Zentralbibliothek Zürich, Graphische Sammlung und Fotoarchiv
description: Auf der Rückseite oben rechts Vermerk mit Bleistift: "6248" (Bildnummer der Kabinettkarte) Exemplar der Zentralbibliothek Zürich, Graphische Sammlung und Fotoarchiv
title: Characterization of Ku70(2)-NLS as bipartite nuclear localization sequence for non-viral gene delivery.
Creators: name: Matschke, Johannes
name: Bohla, Alexander
name: Maucksch, Christof
name: Mittal, Rashmi
name: Rudolph, Carsten
name: Rosenecker, Joseph
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2012
Subjects: subject: 610

description: Several barriers have to be overcome in order to achieve gene expression in target cells, e.g. cellular uptake, endosomal release and translocation to the nucleus. Nuclear localization sequences (NLS) enhance gene delivery by increasing the uptake of plasmid DNA (pDNA) to the nucleus. So far, only monopartite NLS were analysed for non-viral gene delivery. In this study, we examined the characteristics of a novel bipartite NLS like construct, namely NLS Ku70. We synthesized a dimeric structure of a modified NLS from the Ku70 protein (Ku70(2)-NLS), a nuclear transport active mutant of Ku70(2)-NLS (s1Ku70(2)-NLS) and a nuclear transport deficient mutant of Ku70(2)-NLS (s2Ku70(2)). We examined the transfection efficiency of binary Ku70(2)-NLS/DNA and ternary Ku70(2)-NLS/PEI/DNA gene vector complexes in vitro by using standard transfection protocols as well as the magnetofection method. The application of Ku70(2)-NLS and s1Ku70(2)-NLS increased gene transfer efficiency in vitro and in vivo. This study shows for the first time that the use of bipartite NLS compounds alone or in combination with cationic polymers is a promising strategy to enhance the efficiency of non-viral gene transfer.
Association of pre-/early pregnancy high blood pressure and pregnancy outcomes: a systemic review and meta-analysis
Creators: name: Jin, Ming
name: Liu, Xiaowen
name: Liu, Xiaojing
name: Wu, Yaxian
name: Zhang, Yali
name: Zhang, Le
name: Li, Zhiwen
name: Ye, Rongwei
name: Li, Nan
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Maternal high blood pressure (BP) was associated with adverse pregnancy outcomes. This study aimed to synthesize evidence on the association between high BP prior to or in early pregnancy with maternal and fetal complications. We searched the cohort studies assessing the effect of high BP in the Medline, Embase, Web of Science and China National Knowledge Internet databases. A random-effects model was used to estimate the pooled odds ratios (ORs) with 95% confidence intervals (CIs). The protocol was registered in PROSPERRO (CRD 42023414945). 23 eligible studies were identified. High BP prior to or in early pregnancy was associated with higher odds of hypertensive disorders of pregnancy (OR 2.90, 95% CI 1.91–3.89), gestational hypertension (2.56, 2.01–3.12), preeclampsia (3.20, 2.66–3.74), gestational diabetes mellitus (1.71, 1.36–2.06), preterm birth (1.66, 1.39–1.93), stillbirth (2.01, 1.45–2.58) and neonatal intensive care unit admission (1.22, 1.08–1.37). Subgroup analyses indicated that pre-hypertension could significantly increase the odds of these outcomes except for stillbirth, though the odds were lower than hypertension. High BP prior to or in early pregnancy was associated with adverse pregnancy outcomes and this association increased with hypertension severity. The findings emphasized an urgent need for heightened surveillance for maternal BP, especially pre-hypertensive status.
Definitive Zurich Relative Sunspot Number (daily values) R 1949; Definitive Relativzahlen der Sonnenflecken 1949.
Tabellenblatt (1) mit den endgültigen Werten, erstellt und berechnet durch Max Waldmeier, Eidgenössische Sternwarte Zürich
Creators: name: Eidgenössische Sternwarte in Zürich (ETH Zürich bzw. vor 1911 Polytechnikum)
Publisher: name: [s.n.]
Year: 1949

description: Handschriftlich ausgefüllte Tabelle (Vordruck) für tägliche Sonnenfleckenrelativzahlen R im Jahr 1949.
Von Max Waldmeier geführt und als Blatt Nr. 1 ins Jahresregister 1949 eingeordnet.
Publikation der Daten in: Die Sonnenaktivität im Jahre 1949, von Max Waldmeier, Astronomische Mitteilungen der Eidg. Sternwarte Zürich Nr. 172, Zürich 1950, Tab. 1 - siehe auch https://www.ngzh.ch/archiv/1950_95/95_3/95_24.pdf
description: ETH-Bibliothek
title: Immediate and heterogeneous response of the LiaFSR two-component system of Bacillus subtilis to the peptide antibiotic bacitracin.
Creators: name: Kesel, Sara
name: Mader, Andreas
name: Höfler, Carolin
name: Mascher, Thorsten
name: Leisner, Madeleine
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2013
Subjects: subject: 570

description: Two-component signal transduction systems are one means of bacteria to respond to external stimuli. The LiaFSR two-component system of Bacillus subtilis consists of a regular two-component system LiaRS comprising the core Histidine Kinase (HK) LiaS and the Response Regulator (RR) LiaR and additionally the accessory protein LiaF, which acts as a negative regulator of LiaRS-dependent signal transduction. The complete LiaFSR system was shown to respond to various peptide antibiotics interfering with cell wall biosynthesis, including bacitracin.Here we study the response of the LiaFSR system to various concentrations of the peptide antibiotic bacitracin. Using quantitative fluorescence microscopy, we performed a whole population study analyzed on the single cell level. We investigated switching from the non-induced 'OFF' state into the bacitracin-induced 'ON' state by monitoring gene expression of a fluorescent reporter from the RR-regulated liaI promoter. We found that switching into the 'ON' state occurred within less than 20 min in a well-defined switching window, independent of the bacitracin concentration. The switching rate and the basal expression rate decreased at low bacitracin concentrations, establishing clear heterogeneity 60 min after bacitracin induction. Finally, we performed time-lapse microscopy of single cells confirming the quantitative response as obtained in the whole population analysis for high bacitracin concentrations.The LiaFSR system exhibits an immediate, heterogeneous and graded response to the inducer bacitracin in the exponential growth phase.
title: Die Wahrnehmung Tschechiens im Weinviertel
Creators: name: Hienert, Franziska
Year: 2013

description: Die vorliegende Diplomarbeit beschäftigt sich mit einer Fragestellung aus dem Gebiet der Wahrnehmungsgeographie und setzt sich aus einem theoretischen und empirischen Teil zusammen. Untersucht wurde die Wahrnehmung Tschechiens im Weinviertel. Die in der Arbeit beschriebene Grenzregion ist ein Gebiet, welches durch einen gemeinsamen geschichtlichen Hintergrund geprägt ist. Die Grenze hat im Laufe der Zeit viele verschiedene Funktionen übernommen und war einige Zeit unüberwindbar. Gerade der Fall des Eisernen Vorhangs im Jahr 1989 und die Erweiterung des Schengen-Raums haben dazu geführt, dass sich Österreich und Tschechien annähern und das Grenzgebiet als Potential dieser Region gesehen wird. Durch grenzüberschreitende Projekte und Kooperationen soll diese Region gestärkt und die Grenze, die zum Teil nach wie vor in den Köpfen der BewohnerInnen verankert ist, abgebaut werden. Diese Diplomarbeit soll dem Leser ermöglichen, einen Überblick über die Forschung der Wahrnehmungsgeographie zu gewinnen und anhand empirischer Ergebnisse die Wahrnehmung Tschechiens im Weinviertel zu bewerten. Dazu werden zunächst wichtige Begriffe der Wahrnehmungsgeographie, der raumbezogenen Identität und der Grenzraumforschung näher erläutert. Die Darstellung des geschichtlichen Hintergrundes soll dabei helfen, die Ergebnisse der Befragung über die verschiedenen Empfindungen und Wahrnehmungen der WeinviertlerInnen über Tschechien und deren BewohnerInnen besser nachvollziehen zu können.
title: MRI evidence for altered venous drainage and intracranial compliance in mild traumatic brain injury.
Creators: name: Pomschar, Andreas
name: Koerte, Inga
name: Lee, Sang
name: Laubender, Ruediger P.
name: Straube, Andreas
name: Heinen, Florian
name: Ertl-Wagner, Birgit
name: Alperin, Noam
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2013
Subjects: subject: 570

description: To compare venous drainage patterns and associated intracranial hydrodynamics between subjects who experienced mild traumatic brain injury (mTBI) and age- and gender-matched controls.Thirty adult subjects (15 with mTBI and 15 age- and gender-matched controls) were investigated using a 3T MR scanner. Time since trauma was 0.5 to 29 years (mean 11.4 years). A 2D-time-of-flight MR-venography of the upper neck was performed to visualize the cervical venous vasculature. Cerebral venous drainage through primary and secondary channels, and intracranial compliance index and pressure were derived using cine-phase contrast imaging of the cerebral arterial inflow, venous outflow, and the craniospinal CSF flow. The intracranial compliance index is the defined as the ratio of maximal intracranial volume and pressure changes during the cardiac cycle. MR estimated ICP was then obtained through the inverse relationship between compliance and ICP.Compared to the controls, subjects with mTBI demonstrated a significantly smaller percentage of venous outflow through internal jugular veins (60.9±21% vs. controls: 76.8±10%; p = 0.01) compensated by an increased drainage through secondary veins (12.3±10.9% vs. 5.5±3.3%; p<0.03). Mean intracranial compliance index was significantly lower in the mTBI cohort (5.8±1.4 vs. controls 8.4±1.9; p<0.0007). Consequently, MR estimate of intracranial pressure was significantly higher in the mTBI cohort (12.5±2.9 mmHg vs. 8.8±2.0 mmHg; p<0.0007).mTBI is associated with increased venous drainage through secondary pathways. This reflects higher outflow impedance, which may explain the finding of reduced intracranial compliance. These results suggest that hemodynamic and hydrodynamic changes following mTBI persist even in the absence of clinical symptoms and abnormal findings in conventional MR imaging.
A preclinical model of peripheral T-cell lymphoma GATA3 reveals DNA damage response pathway vulnerability.
Creators: name: Kuczynski, Elizabeth A
name: Morlino, Giulia
name: Peter, Alison
name: Coenen-Stass, Anna ML
name: Moss, Jennifer I
name: Wali, Neha
name: Delpuech, Oona
name: Reddy, Avinash
name: Solanki, Anisha
name: Sinclair, Charles
name: Calado, Dinis P
name: Carnevalli, Larissa S
Publisher: name: The Francis Crick Institute
Year: 2022
Subjects: subject: Model organisms
subject: Tumour Biology
subject: Signalling & Oncogenes
subject: Genetics & Genomics
subject: Developmental Biology
subject: Stem Cells
subject: Chemical Biology & High Throughput
subject: Immunology
subject: FOS: Clinical medicine

description: Peripheral T-cell lymphoma (PTCL) represents a rare group of heterogeneous diseases in urgent need of effective treatments. A scarcity of disease-relevant preclinical models hinders research advances. Here, we isolated a novel mouse (m)PTCL by serially transplanting a lymphoma from a germinal center B-cell hyperplasia model (Cγ1-Cre Blimp1fl/fl ) through immune-competent mice. Lymphoma cells were identified as clonal TCRβ+ T-helper cells expressing T-follicular helper markers. We also observed coincident B-cell activation and development of a de novo B-cell lymphoma in the model, reminiscent of B-cell activation/lymphomagenesis found in human PTCL. Molecular profiling linked the mPTCL to the high-risk "GATA3" subtype of PTCL, showing GATA3 and Th2 gene expression, PI3K/mTOR pathway enrichment, hyperactivated MYC, and genome instability. Exome sequencing identified a human-relevant oncogenic β-catenin mutation possibly involved in T-cell lymphomagenesis. Prolonged treatment responses were achieved in vivo by targeting ATR in the DNA damage response (DDR), a result corroborated in PTCL cell lines. This work provides mechanistic insight into the molecular and immunological drivers of T-cell lymphomagenesis and proposes DDR inhibition as an effective and readily translatable therapy in PTCL.