cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
STUDIO CLINICO_ PNRR LEMONADE 568.2023
Creators: name: MultiMedica Data Management
Publisher: name: Zenodo
Year: 2024

description: STUDIO CLINICO_ PNRR LEMONADE 568.2023

TITOLO : LEMONADE - La variante di LAV-BFIFB4 associata alla longevità: un nuovo strumento contro la trombocitosi e la “resistenza all’aspirina” nel Diabete

Promotore: MultiMedica

Il progetto è finanziato dal Piano Nazionale di Ripresa e Resilienza (PNRR)

Codice progetto: PNRR-MAD-2022-12376723

Studio osservazionale prospettico monocentrico

Lettera Richiesta CE 10.3.2023 e risposta al CE 27.3.2023

Sinossi Versione  v. 1.1 del 27.3.2023 (post CE)

Verbale 18-2023 e 25.2023(def)
In vitro characterization of 4′-(p-toluenesulfonylamide)-4-hydroxychalcone using human liver microsomes and recombinant cytochrome P450s
Creators: name: Boram Lee
name: Zhexue Wu
name: Taeho Lee
name: Tan, Xue Fei
name: Park, Ki Hun
name: Kwang-Hyeon Liu
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Cancer
subject: Inorganic Chemistry

description: 1. 4′-(p-Toluenesulfonylamide)-4-hydroxychalcone (TSAHC) is a synthetic sulfonylamino chalcone compound possessing anti-cancer properties. The aim of this study was to elucidate the metabolism of TSAHC in human liver microsomes (HLMs) and to characterize the cytochrome P450 (P450) enzymes that are involved in the metabolism of TSAHC. 2. TSAHC was incubated with HLMs or recombinant P450 isoforms (rP450) in the presence of an nicotinamide adenine dinucleotide phosphate, reduced form (NADPH)-regenerating system. The metabolites were identified and analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). P450 isoforms, responsible for TSAHC metabolite formation, were characterized by chemical inhibition and correlation studies in HLMs and enzyme kinetic studies with a panel of rP450 isoforms. 3. Two hydroxyl metabolites, that is M1 and M2, were produced from the human liver microsomal incubations (Km and Vmax values were 2.46 µM and 85.1 pmol/min/mg protein for M1 and 9.98 µM and 32.1 pmol/min/mg protein for M2, respectively). The specific P450 isoforms responsible for two hydroxy-TSAHC formations were identified using a combination of chemical inhibition, correlation analysis and metabolism by expressed recombinant P450 isoforms. The known P450 enzyme activities and the rate of TSAHC metabolite formation in the 15 HLMs showed that TSAHC metabolism is correlated with CYP2C and CYP3A activity. The P450 isoform-selective inhibition study in HLMs and the incubation study of cDNA-expressed enzymes also showed that two hydroxyl metabolites M1 and M2 biotransformed from TSAHC are mainly mediated by CYP2C and CYP3A, respectively. These findings suggest that CYP2C8, CYP2C9, CYP2C19, CYP3A4 and CYP3A5 isoforms are major enzymes contributing to TSAHC metabolism.
Immune-tolerant elastin-like polypeptides (iTEPs) and their application as CTL vaccine carriers
Creators: name: S. Cho
name: S. Dong
name: K. N. Parent
name: M. Chen
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Chemistry
subject: Pharmacology
subject: Microbiology
subject: FOS: Biological sciences

description: Background: Cytotoxic T lymphocyte (CTL) vaccine carriers are known to enhance the efficacy of vaccines, but a search for more effective carriers is warranted. Elastin-like polypeptides (ELPs) have been examined for many medical applications but not as CTL vaccine carriers.Purpose: We aimed to create immune tolerant ELPs using a new polypeptide engineering practice and create CTL vaccine carriers using the ELPs.Results: Four sets of novel ELPs, termed immune-tolerant elastin-like polypeptide (iTEP) were generated according to the principles dictating humoral immunogenicity of polypeptides and phase transition property of ELPs. The iTEPs were non-immunogenic in mice. Their phase transition feature was confirmed through a turbidity assay. An iTEP nanoparticle (NP) was assembled from an amphiphilic iTEP copolymer plus a CTL peptide vaccine, SIINFEKL. The NP facilitated the presentation of the vaccine by dendritic cells (DCs) and enhanced vaccine-induced CTL responses.Discussion: A new ELP design and development practice was established. The non-canonical motif and the immune tolerant nature of the iTEPs broaden our insights about ELPs. ELPs, for the first time, were successfully used as carriers for CTL vaccines.Conclusion: It is feasible to concurrently engineer both immune-tolerant and functional peptide materials. ELPs are a promising type of CTL vaccine carriers.
AUTEN-67, an autophagy-enhancing drug candidate with potent antiaging and neuroprotective effects
Creators: name: Papp, Diána
name: Kovács, Tibor
name: Billes, Viktor
name: Máté Varga
name: Tarnóci, Anna
name: Hackler, László
name: Puskás, László G
name: Liliom, Hanna
name: Tárnok, Krisztián
name: Schlett, Katalin
name: Borsy, Adrienn
name: Pádár, Zsolt
name: Kovács, Attila L
name: Hegedűs, Krisztina
name: Juhász, Gábor
name: Komlós, Marcell
name: Erdős, Attila
name: Gulyás, Balázs
name: Vellai, Tibor
Publisher: name: Taylor & Francis
Year: 2016
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Autophagy is a major molecular mechanism that eliminates cellular damage in eukaryotic organisms. Basal levels of autophagy are required for maintaining cellular homeostasis and functioning. Defects in the autophagic process are implicated in the development of various age-dependent pathologies including cancer and neurodegenerative diseases, as well as in accelerated aging. Genetic activation of autophagy has been shown to retard the accumulation of damaged cytoplasmic constituents, delay the incidence of age-dependent diseases, and extend life span in genetic models. This implies that autophagy serves as a therapeutic target in treating such pathologies. Although several autophagy-inducing chemical agents have been identified, the majority of them operate upstream of the core autophagic process, thereby exerting undesired side effects. Here, we screened a small-molecule library for specific inhibitors of MTMR14, a myotubularin-related phosphatase antagonizing the formation of autophagic membrane structures, and isolated AUTEN-67 (autophagy enhancer-67) that significantly increases autophagic flux in cell lines and in vivo models. AUTEN-67 promotes longevity and protects neurons from undergoing stress-induced cell death. It also restores nesting behavior in a murine model of Alzheimer disease, without apparent side effects. Thus, AUTEN-67 is a potent drug candidate for treating autophagy-related diseases.
AUTEN-67, an autophagy-enhancing drug candidate with potent antiaging and neuroprotective effects
Creators: name: Papp, Diána
name: Kovács, Tibor
name: Billes, Viktor
name: Máté Varga
name: Tarnóci, Anna
name: Hackler, László
name: Puskás, László G
name: Liliom, Hanna
name: Tárnok, Krisztián
name: Schlett, Katalin
name: Borsy, Adrienn
name: Pádár, Zsolt
name: Kovács, Attila L
name: Hegedűs, Krisztina
name: Juhász, Gábor
name: Komlós, Marcell
name: Erdős, Attila
name: Gulyás, Balázs
name: Vellai, Tibor
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: 69999 Biological Sciences not elsewhere classified
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Autophagy is a major molecular mechanism that eliminates cellular damage in eukaryotic organisms. Basal levels of autophagy are required for maintaining cellular homeostasis and functioning. Defects in the autophagic process are implicated in the development of various age-dependent pathologies including cancer and neurodegenerative diseases, as well as in accelerated aging. Genetic activation of autophagy has been shown to retard the accumulation of damaged cytoplasmic constituents, delay the incidence of age-dependent diseases, and extend life span in genetic models. This implies that autophagy serves as a therapeutic target in treating such pathologies. Although several autophagy-inducing chemical agents have been identified, the majority of them operate upstream of the core autophagic process, thereby exerting undesired side effects. Here, we screened a small-molecule library for specific inhibitors of MTMR14, a myotubularin-related phosphatase antagonizing the formation of autophagic membrane structures, and isolated AUTEN-67 (autophagy enhancer-67) that significantly increases autophagic flux in cell lines and in vivo models. AUTEN-67 promotes longevity and protects neurons from undergoing stress-induced cell death. It also restores nesting behavior in a murine model of Alzheimer disease, without apparent side effects. Thus, AUTEN-67 is a potent drug candidate for treating autophagy-related diseases.
Selective loss of younger erythrocytes from blood circulation and changes in erythropoietic patterns in bone marrow and spleen in mouse anemia induced by poly-dispersed single-walled carbon nanotubes
Creators: name: Nitin Bhardwaj
name: Saxena, Rajiv K.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Computational Biology
subject: Plant Biology
subject: FOS: Biological sciences
subject: Hematology
subject: Cancer
subject: Developmental Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: Evolutionary Biology
subject: Physiology
subject: Genetics
subject: Cell Biology
subject: Biochemistry

description: Administration of poly-dispersed acid-functionalized single-walled carbon nanotubes (AF-SWCNTs, 10 µg intravenously on alternate days) induced a sustained anemia in mice. Using a modified double in vivo biotinylation (DIB) technique, blood counts of reticulocytes and erythrocytes of different age groups were simultaneously enumerated in control and AF-SWCNT treated mice. A sustained reticulocytosis was observed in AF-SWCNT treated mice. Young erythrocytes (up to 7 days old) that are normally resistant to elimination in control mice were eliminated at a significant rate in AF-SWCNT treated mice. Old erythrocytes, however, accumulated in circulation indicating that younger erythrocytes were selectively eliminated from the blood circulation of AF-SWCNT treated mice. Cells representing various stages of erythroid differentiation in bone marrow and spleen were enumerated flow cytometrically by double staining with anti-Ter119 and anti-transferrin receptor (CD71) monoclonal antibodies. Proportion of erythroid cells was significantly reduced (up to 27%) in bone marrow (BM) indicating a fall in erythropoietic activity. A concomitant increase in the spleen erythroid population was however observed that could be a compensatory response. Changes in erythroid populations in bone marrow and spleen correlated with changes in erythroblast-A population in these organs that represent an early stage of erythroid differentiation. Uptake of intravenously administered fluorescence tagged AF-SWCNTs (FAF-SWCNTs) was relatively low (3–4%) in erythroid cells in bone marrow and spleen. A significantly higher proportion of pro-erythroblasts and erythroblast-A (early stages of erythroid differentiation) took-up FAF-SWCNTs. Uptake of AF-SWCNTs by early precursors of erythroid differentiation with toxic consequences may be a contributing factor in AF-SWCNT induced anemia.
AUTEN-67, an autophagy-enhancing drug candidate with potent antiaging and neuroprotective effects
Creators: name: Papp, Diána
name: Kovács, Tibor
name: Billes, Viktor
name: Máté Varga
name: Tarnóci, Anna
name: Hackler, László
name: Puskás, László G.
name: Liliom, Hanna
name: Tárnok, Krisztián
name: Schlett, Katalin
name: Borsy, Adrienn
name: Pádár, Zsolt
name: Kovács, Attila L.
name: Hegedűs, Krisztina
name: Juhász, Gábor
name: Komlós, Marcell
name: Erdős, Attila
name: Gulyás, Balázs
name: Vellai, Tibor
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Biological Sciences
subject: Pharmacology
subject: Physiology
subject: FOS: Biological sciences
subject: Neuroscience
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Biochemistry

description: Autophagy is a major molecular mechanism that eliminates cellular damage in eukaryotic organisms. Basal levels of autophagy are required for maintaining cellular homeostasis and functioning. Defects in the autophagic process are implicated in the development of various age-dependent pathologies including cancer and neurodegenerative diseases, as well as in accelerated aging. Genetic activation of autophagy has been shown to retard the accumulation of damaged cytoplasmic constituents, delay the incidence of age-dependent diseases and extend life span in genetic models. This implies that autophagy serves as a therapeutic target in treating such pathologies. Although several autophagy-inducing chemical agents have been identified, the majority of them operate upstream of the core autophagic process, thereby exerting undesired side effects. Here, we screened a small-molecule library for specific inhibitors of MTMR14, a myotubularin-related phosphatase antagonizing the formation of autophagic membrane structures, and isolated AUTEN-67 (autophagy enhancer-67) that significantly increases autophagic flux in cell lines and in vivo models. AUTEN-67 promotes longevity and protects neurons from undergoing stress-induced cell death. It also restores nesting behavior in a murine model of Alzheimer disease, without apparent side effects. Thus, AUTEN-67 is a potent drug candidate for treating autophagy-related diseases.
title: The impact of green walls on air pollution and thermal comfort at pedestrian level in street canyon
Creators: name: Laurel, Raymund
Publisher: name: University of Southampton
Year: 2023

description: Urban areas grapple with challenges like poor air quality from traffic and increasing summer heat due to heat-absorbing surfaces such as concrete and asphalt. Green infrastructure offers solutions but faces limitations in urban settings. This study explores green walls as an alternative to improving air quality and outdoor comfort. Three scenarios were tested: base case (BC), green wall (GW), and green wall with trees (GW+T), using ENVI-met. The green wall's impact was prominent on the windward side against prevailing pollution. In the afternoon, it notably reduced NO2 by up to 32% and PMs by 31% compared to BC. Additionally, green walls lowered mean radiant temperature by up to 5Â°C, especially in peak high temperatures. This study underscores the potential of green walls as an effective means of mitigating urban air pollution and enhancing summer outdoor comfort, especially when incorporated strategically.
Microvascular and mitochondrial dysfunction in the female F1 generation after gestational TiO2 nanoparticle exposure
Creators: name: Stapleton, Phoebe A.
name: Nichols, Cody E.
name: Jinghai Yi
name: McBride, Carroll R.
name: Minarchick, Valerie C.
name: Shepherd, Danielle L.
name: Hollander, John M.
name: Nurkiewicz, Timothy R.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Science Policy
subject: Developmental Biology
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Genetics
subject: Cell Biology
subject: Medicine

description: Due to the ongoing evolution of nanotechnology, there is a growing need to assess the toxicological outcomes in under-studied populations in order to properly consider the potential of engineered nanomaterials (ENM) and fully enhance their safety. Recently, we and others have explored the vascular consequences associated with gestational nanomaterial exposure, reporting microvascular dysfunction within the uterine circulation of pregnant dams and the tail artery of fetal pups. It has been proposed (via work derived by the Barker Hypothesis) that mitochondrial dysfunction and subsequent oxidative stress mechanisms as a possible link between a hostile gestational environment and adult disease. Therefore, in this study, we exposed pregnant Sprague-Dawley rats to nanosized titanium dioxide aerosols after implantation (gestational day 6). Pups were delivered, and the progeny grew into adulthood. Microvascular reactivity, mitochondrial respiration and hydrogen peroxide production of the coronary and uterine circulations of the female offspring were evaluated. While there were no significant differences within the maternal or litter characteristics, endothelium-dependent dilation and active mechanotransduction in both coronary and uterine arterioles were significantly impaired. In addition, there was a significant reduction in maximal mitochondrial respiration (state 3) in the left ventricle and uterus. These studies demonstrate microvascular dysfunction and coincide with mitochondrial inefficiencies in both the cardiac and uterine tissues, which may represent initial evidence that prenatal ENM exposure produces microvascular impairments that persist throughout multiple developmental stages.
title: Potential Applications of BET Inhibitors in Combination with other Anti-Cancer Agents
Creators: name: Gray, Araminta
Publisher: name: University of Kent
Year: 2024

description: Bromodomain and Extra-Terminal Domain (BET) proteins are a family of epigenetic readers which bind to specific acetylated lysine residues located on histone tails. These proteins are involved in the regulation of a number of essential biological functions, consequently aberrations of these proteins and dysregulation of the pathways they regulate is associated with oncogenesis. A number of studies have provided proof of concept that inhibition of BET proteins could be a viable therapeutic strategy for the treatment of cancer.

A qualitative systematic literary review was conducted, with a focus on the development of resistance to BET inhibitors in cancer, as well as the use of BET inhibitors to aid overcoming drug resistance to other classes of chemotherapeutics. The review identified several factors responsible for the acquisition of resistance to BET inhibitors which might aid in determining effective combination therapies and guide the development of next-generation BET inhibitors. Furthermore, the review showed evidence of BET inhibitors conferring a synergistic effect in resistant cancer cell lines when used in combination with other chemotherapeutic agents, in some instances assisting in overcoming drug resistance by increasing the sensitivity of cancer cell lines to other anti-cancer agents.

Cell viability of the neuroblastoma cell lines following treatment with the platinum-based drugs, carboplatin and oxaliplatin, and the BET inhibitors, JQ1 and I-BET726, as single agents was assessed. Each of the cell lines demonstrated increased sensitivity to I-BET726 compared to JQ1, with this effect most apparent in the oxaliplatin-resistant neuroblastoma cell line. Furthermore, the responses to JQ1 demonstrated greater variation than the responses to I-BET726.

Moreover, this study investigated the impact of the structurally different BET inhibitors on the sensitivity of the neuroblastoma cell line, UKF-NB-3, and its carboplatin- (UKF-NB-3rCARBO2000) and oxaliplatin-resistant (UKF-NB-3rOXALI2000) sublines to carboplatin and oxaliplatin respectively. Pre-treatment with the BET inhibitors increased the sensitivity of the cell lines to their respective platinum compound, with the response to the platinum agents improving as the pre-treatment concentration and duration increased.

The findings from the literary review highlights the potential of BET inhibitors to aid in overcoming resistance when used in combination with other classes of chemotherapeutics. This finding is corroborated by the results generated within the wet lab portion of this study which demonstrate this in neuroblastoma against platinum-based drugs.
Essays in Causal Inference with Panel Data (Data Management Plan)
Creators: name: Schenk, T.D.
Publisher: name: University of Amsterdam / Amsterdam University of Applied Sciences
Year: 2024
Subjects: Social Science

description: This dissertation discusses and advances the econometric methods in the field of causal inference with panel data. In particular, I improve difference-in-differences (DiD) type of methods in multiple aspects. Being one of the most commonly used empirical strategy, researchers in all fields apply these methods to answer questions such as “what is the effect of a labor market interventions on earnings?”, ”to what extent do changes in the school leaving age affect study choices?” or ”by how much have the policy instruments of the clean-air-act reduced emissions of greenhouse gases?”. The three chapters of this dissertation address issues that naturally arise in these applications.
Surfactant protein A (SP-A) inhibits agglomeration and macrophage uptake of toxic amine modified nanoparticles
Creators: name: Ding, Ping
name: Griffiths, Mark
name: Clark, Howard
name: Madsen, Jens
name: Zofi McKenzie
name: Kendall, Michaela
name: Rose-Marie Mackay
name: Whitwell, Harry
name: Elgy, Christine
name: Sumeet Mahajan
name: Morgan, Cliff
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Immunology
subject: FOS: Clinical medicine
subject: Astronomy, Astrophysics, Space Science
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Cell Biology
subject: Microbiology
subject: FOS: Biological sciences
subject: Medicine
subject: Physics
subject: Biochemistry

description: The lung provides the main route for nanomaterial exposure. Surfactant protein A (SP-A) is an important respiratory innate immune molecule with the ability to bind or opsonise pathogens to enhance phagocytic removal from the airways. We hypothesised that SP-A, like surfactant protein D, may interact with inhaled nanoparticulates, and that this interaction will be affected by nanoparticle (NP) surface characteristics. In this study, we characterise the interaction of SP-A with unmodified (U-PS) and amine-modified (A-PS) polystyrene particles of varying size and zeta potential using dynamic light scatter analysis. SP-A associated with both 100 nm U-PS and A-PS in a calcium-independent manner. SP-A induced significant calcium-dependent agglomeration of 100 nm U-PS NPs but resulted in calcium-independent inhibition of A-PS self agglomeration. SP-A enhanced uptake of 100 nm U-PS into macrophage-like RAW264.7 cells in a dose-dependent manner but in contrast inhibited A-PS uptake. Reduced association of A-PS particles in RAW264.7 cells following pre-incubation of SP-A was also observed with coherent anti-Stokes Raman spectroscopy. Consistent with these findings, alveolar macrophages (AMs) from SP-A−/− mice were more efficient at uptake of 100 nm A-PS compared with wild type C57Bl/6 macrophages. No difference in uptake was observed with 500 nm U-PS or A-PS particles. Pre-incubation with SP-A resulted in a significant decrease in uptake of 100 nm A-PS in macrophages isolated from both groups of mice. In contrast, increased uptake by AMs of U-PS was observed after pre-incubation with SP-A. Thus we have demonstrated that SP-A promotes uptake of non-toxic U-PS particles but inhibits the clearance of potentially toxic A-PS particles by blocking uptake into macrophages.
title: SotA LoRaWAN - drunter und drüber
title: Eine State-of-the-Art Analyse von Märkten, Lösungen, Protokollen Und Trends.
titleType: Subtitle
Creators: name: Burkhardt, Detlef
Publisher: name: Zenodo
Year: 2025
Subjects: LoRaWAN
RF

description: tl;dr: Eine SotA Exploration über Technologien, Protokolle, Hard- und Software Architekturen und Lösungen zum Thema LoRaWAN.LoRaWAN hat sich als eine der führenden LPWAN-Technologien etabliert, doch die zugrunde liegenden Architekturen, Protokolle und Lösungen entwickeln sich kontinuierlich weiter. Diese Arbeit bietet eine State-of-the-Art-Analyse der aktuellen Technologien im LoRaWAN-Ökosystem. Sie untersucht die zugrundeliegenden Hard- und Software-Architekturen, darunter Forwarder, Stacks und Netzwerkserver (LNS ... tbd). Neben einer systematischen Erfassung der existierenden Lösungen wird die Interoperabilität zwischen verschiedenen Komponenten betrachtet. Ziel ist es, eine umfassende Momentaufnahme der aktuellen Entwicklungen zu liefern, technische Herausforderungen aufzuzeigen und einen Ausblick auf zukünftige Entwicklungen zu geben.v0.7.5: Initiales DOI Releasev0.7.6: Inhaltsverzeichnis vollständigv0.7.7: Geschite der Funkwellen in 5 Epochen
title: SotA LoRaWAN - drunter und drüber
title: Eine State-of-the-Art Analyse von Märkten, Lösungen, Protokollen Und Trends.
titleType: Subtitle
Creators: name: Burkhardt, Detlef
Publisher: name: Zenodo
Year: 2025
Subjects: LoRaWAN
LPWAN

description: tl;dr: Eine SotA Exploration über Technologien, Protokolle, Hard- und Software Architekturen und Lösungen zum Thema LoRaWAN.LoRaWAN hat sich als eine der führenden LPWAN-Technologien etabliert, doch die zugrunde liegenden Architekturen, Protokolle und Lösungen entwickeln sich kontinuierlich weiter. Diese Arbeit bietet eine State-of-the-Art-Analyse der aktuellen Technologien im LoRaWAN-Ökosystem. Sie untersucht die zugrundeliegenden Hard- und Software-Architekturen, darunter Forwarder, Stacks und Netzwerkserver (LNS ... tbd). Neben einer systematischen Erfassung der existierenden Lösungen wird die Interoperabilität zwischen verschiedenen Komponenten betrachtet. Ziel ist es, eine umfassende Momentaufnahme der aktuellen Entwicklungen zu liefern, technische Herausforderungen aufzuzeigen und einen Ausblick auf zukünftige Entwicklungen zu geben.
title: SotA LoRaWAN - drunter und drüber
title: Eine State-of-the-Art Analyse von Märkten, Lösungen, Protokollen Und Trends.
titleType: Subtitle
Creators: name: Burkhardt, Detlef
Publisher: name: Zenodo
Year: 2025
Subjects: LoRaWAN
LPWAN

description: tl;dr: Eine SotA Exploration über Technologien, Protokolle, Hard- und Software Architekturen und Lösungen zum Thema LoRaWAN.LoRaWAN hat sich als eine der führenden LPWAN-Technologien etabliert, doch die zugrunde liegenden Architekturen, Protokolle und Lösungen entwickeln sich kontinuierlich weiter. Diese Arbeit bietet eine State-of-the-Art-Analyse der aktuellen Technologien im LoRaWAN-Ökosystem. Sie untersucht die zugrundeliegenden Hard- und Software-Architekturen, darunter Forwarder, Stacks und Netzwerkserver (LNS ... tbd). Neben einer systematischen Erfassung der existierenden Lösungen wird die Interoperabilität zwischen verschiedenen Komponenten betrachtet. Ziel ist es, eine umfassende Momentaufnahme der aktuellen Entwicklungen zu liefern, technische Herausforderungen aufzuzeigen und einen Ausblick auf zukünftige Entwicklungen zu geben.v0.7.5: Initiales DOI Releasev0.7.6: Inhaltsverzeichnis vollständigv0.7.7: Geschite der Funkwellen in 5 Epochen (tbd)
IN03192 Rāssahela Rock Inscription 3
Creators: name: Paranavitana, S.
Publisher: name: Zenodo
Year: 2020
Subjects: IN03192
Epigraphia Zeylanica
Rajagala
Rāssahela

description: IN03192 Rāssahela Rock Inscription 3 - Transcript and Translation Source: Paranavitana, S. (1934–41). ‘No. 20. Three Rock-Inscriptions at Rāssahela,’ Epigraphia Zeylanica 4, pp. 169–176.
Pulmonary clearance kinetics and extrapulmonary translocation of seven titanium dioxide nano- and submicron materials following intratracheal administration in rats
Creators: name: Sasaki, Takeshi
name: Guihua Zhang
name: Naohide Shinohara
name: Oshima, Yutaka
name: Kobayashi, Toshio
name: Nobuya Imatanaka
name: Nakai, Makoto
name: Ichinose, Takayuki
name: Kawaguchi, Kenji
name: Gamo, Masashi
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Biotechnology
subject: Pharmacology
subject: Molecular Biology
subject: Cell Biology
subject: Medicine

description: We evaluated and compared the pulmonary clearance kinetics and extrapulmonary translocations of seven titanium dioxide (TiO2) nano- and submicron particles with different characteristics, including size, shape and surface coating. Varying doses of TiO2 nano- and submicron particles dispersed in 0.2% disodium phosphate solution were intratracheally administered to male F344 rats. The rats were euthanized under anesthesia for 3, 28 and 91 days after administration. Ti levels in pulmonary and various extrapulmonary organs were determined using inductively coupled plasma-sector field mass spectrometry (ICP-SFMS). The lungs, including bronchoalveolar lavage fluid (BALF), contained 55–89% of the administered TiO2 dose at 3 days after administration. The pulmonary clearance rate constants, estimated using a one-compartment model, were higher after administration of 0.375–2.0 mg/kg body weight (bw) (0.016–0.020/day) than after administration of 3.0–6.0 mg/kg bw (0.0073–0.013/day) for six uncoated TiO2. In contrast, the clearance rate constant was 0.011, 0.0046 and 0.00018/day following administration of 0.67, 2.0 and 6.0 mg/kg bw TiO2 nanoparticle with Al(OH)3 coating, respectively. Translocation of TiO2 from the lungs to the thoracic lymph nodes increased in a time- and dose-dependent manner. Furthermore, the translocation of TiO2 from the lungs to the thoracic lymph nodes after 91 days was higher when Al(OH)3 coated TiO2 was administered (0.93–6.4%), as compared to uncoated TiO2 (0.016–1.8%). Slight liver translocation was observed (<0.11%), although there was no clear trend related to dose or elapsed time. No significant translocation was observed in other organs including the kidney, spleen and brain.
title: 03_0173
Creators: name: Wesley Baldwin, John
name: Baldwin, John W.
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2018
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: L'ensemble de ces notes ont été crée par John Baldwin lors d'une de ses premières périodes de résidence à Paris. Ces documents comprennent tous les magistri qu’il avait pu rencontrer dans ses sources. Aux XIIème et XIIIème siècles, les universités n'existant pas encore, le titre de magister s'il évoque certainement une compétence n'est pas rattaché de façon systématique au passage par les écoles. De surcroît, les magistris sont le plus souvent désignés par leur seul prénom. La lecture de ces données est donc difficile et suppose un long travail pour tenter d'identifier un individu auquel on pourrait rattacher plusieurs mentions. John Baldwin avait donc renoncé à utiliser ces données pour donner un prolongement à sa magnifique étude sur les gradués d'université et leur emploi par les Capétiens et les Plantagenêts. Néanmoins, il a conservé ces données et elles sont potentiellement très utile dans le cadre de Studium, comme le sont toutes les mentions dans les volumes des Fasti Ecclesiae Gallicanae de chanoines portant ce titre de magister sans autres précisions. L'ampleur des dépouillements rend ces données très utiles et nous devons une grande reconnaissance à John Baldwin pour avoir pris la peine de faire photocopier ses fiches et de nous les avoir transmises amicalement.
Les données ainsi que les images des fiches sont accessibles sur le site Internet à l'adresse suivante : http://studium-baldwin.lamop.fr/.
Les transcriptions des fiches ont été effectuées par des étudiants de Paris 1 Panthéon - Sorbonne mais elles n'ont pas été corrigées par la suite.
description: Relation: https://lamop.hypotheses.org/
Low-cost wind turbine aeroacoustic predictions using actuator lines
Creators: name: Botero-Bolivar, Laura
name: Marino, Oscar A
name: Venner, Cornelis H.
name: de Santana, Leandro D.
name: Ferrer, Esteban
Publisher: name: arXiv
Year: 2024
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: Aerodynamic noise is a limitation for further exploitation of wind energy resources. As this type of noise is caused by the interaction of turbulent flow with the airframe, a detailed resolution of the flow is necessary to obtain an accurate prediction of the far-field noise. Computational fluid dynamic (CFD) solvers simulate the flow field but only at a high computational cost, which is much increased when the acoustic field is resolved. Therefore, wind turbine noise predictions using numerical approaches remain a challenge. This paper presents a methodology that couples (relatively fast) wind turbine CFD simulations using actuator lines with a fast turn-around noise prediction method. The flow field is simulated using actuator lines and large eddy simulations. The noise prediction method is based on the Amiet-Schlinker's theory for rotatory noise sources, considering leading- and trailing-edge noise as unique noise sources. A 2D panel code (XFOIL) calculates the sectional forces and boundary layer quantities. The resulting methodology for the noise prediction method is of high fidelity since the wind turbine geometry is accounted for in both flow and acoustics predictions. Results are compared with field measurements of a full-scale wind turbine for two operational conditions, validating the results of this research.
description: 13 pages, 12 figures
Υποστηρικτική εργαλειοθήκη για εκπαιδευτικούς
Creators: name: Scheuer, Claude
name: Heck, Sandra
Publisher: name: Zenodo
Year: 2020
Subjects: motor competence
support toolkit
children
teacher
promotion
assessment

description: Στο πλαίσιο του έργου BMC-EU (Βασικές Κινητικές Δεξιότητες στην Ευρώπη) αναπτύχθηκε το πλαίσιο υποστήριξης και η υποστηρικτική εργαλειοθήκη βάση του μοντέλου των βασικών κινητικών δεξιοτήτων και των αποτελεσμάτων από τη συλλογή δεδομένων κατά τη φάση 1 του έργου, το οποίο αποτελεί μέρος της πνευματικής παραγωγής 3. Ο σκοπός της εργαλειοθήκης αυτής είναι να εφαρμοστεί στα μαθήματα φυσικής αγωγής, ώστε να προσαρμοστούν κατάλληλα τόσο το περιεχόμενο όσο και οι μέθοδοι διδασκαλίας της φυσικής αγωγής. Ως πρώτο βήμα, το υποστηρικτικό πλαίσιο αναπτύχθηκε για τη διάγνωση των βασικών κινητικών δεξιοτήτων των μαθητών, καθώς και για την αξιολόγηση των δυνατοτήτων τους, ώστε στη συνέχεια να δημιουργηθούν συγκεκριμένα παρεμβατικά προγράμματα. Με βάση το πλαίσιο αυτό, αναπτύχθηκαν υποστηρικτικά φυλλάδια με τη μορφή της υποστηρικτικής εργαλειοθήκης, έτοιμα προς εφαρμογή σε συγκεκριμένες εκπαιδευτικές συνθήκες για την υποστήριξη μαθητών με πρόσθετες ανάγκες στις βασικές κινητικές δεξιότητες. Η υποστηρικτική εργαλειοθήκη περιλαμβάνει οδηγίες για την ερμηνεία των αποτελεσμάτων του MOBAK (Motorische Basiskompetenzen; Γερμανικά για τις βασικές κινητικές δεξιότητες), το πλαίσιο υποστήριξης ΜΟΒΑΚ, ένα γλωσσάρι, καθώς και την υποστηρικτική εργαλειοθήκη με εργαλεία για καθηγητές φυσικής αγωγής υπό τη μορφή καρτών περιγραφής διαδικασιών και καρτών δραστηριοτήτων ΜΟΒΑΚ, βασισμένα στις αρχές της παραλλαγής των δραστηριοτήτων και σε μία προσέγγιση προσανατολισμένη στις δεξιότητες.
description: Project "Basic Motor Competencies in Europe – Assessment and Promotion" (BMC-EU); Funder: European Commission - Erasmus+ Programme of the European Union; Programme: Erasmus+ Sport: Collaborative Partnerships - 2017; Reference: 590777-EPP-1-2017-1-DE-SPO-SCP; Timeline: January 2018 - December 2019; Project Sheet: https://ec.europa.eu/programmes/erasmus-plus/projects/eplus-project-details/#project/590777-EPP-1-2017-1-DE-SPO-SCP
Covid-19: Physical Distancing Will Make Science Closer to Citizen Participation in Decision Making
Creators: name: Cinti, Stefano
Publisher: name: Substantia
Year: 2020

description: Nowadays, social distancing is mandatory in various countries worldwide. It is defined as a non-pharmaceutical interventions for preventing the spread of COVID-19, by maintaining a distance among people and reducing the frequency of contacts with each other. However, the correct definition, as reported somewhere, should be physical distancing. Populations are “socially” close, citizens are experimenting novel approaches of communication, and novel way to help. Of course, in the era of social networks, everybody is enabled to get in touch, even with people that were missing since lot of time. The velocity of how life goes, the necessity of getting results, the demonstration of own value and the invention of brand-new strategies to overcome the generic “everyday” issues, covering all the fields such as family, job, friends, etc., are facing with a pandemic monster.
description: Substantia, Vol 4 No 1 Suppl. 1 (2020) - Open Stream on Covid-19 Emergency
Food-Insecure Households Score Lower on Diet Quality Compared to Food-Secure Households
Creators: name: Mancino, Lisa
name: Gregory, Christian A.
name: Mancino, Lisa
name: Gregory, Christian A.
Publisher: name: Unknown
Year: 2020
Subjects: subject: Consumer/Household Economics
subject: Food Consumption/Nutrition/Food Safety
subject: Food Security and Poverty
subject: Health Economics and Policy
subject: food-insecure
subject: food-secure
subject: food safety
subject: low-income
subject: Food Acquisition and Purchase Survey (FoodAPS)
subject: Healthy Eating Index-2010 (HEI-2010)

description: ERS researchers scored the nutritional quality of a week’s worth of food purchases and acquisitions by low-income food-secure and food-insecure households. For every 1,000 calories of food at home acquired, food-secure households acquired more total fruit, whole fruit, total protein, and seafood and plant proteins compared with food-insecure households.
African Swine Fever Shrinks Pork Production in China, Swells Demand for Imported Pork
Creators: name: Haley, Mildred
name: Gale, Fred
name: Haley, Mildred
name: Gale, Fred
Publisher: name: Unknown
Year: 2020
Subjects: subject: Farm Management
subject: International Development
subject: International Relations/Trade
subject: Livestock Production/Industries
subject: hogs
subject: pork
subject: African Swine Fever (ASF)
subject: China

description: Although the rapid spread of African Swine Fever across China decimated the world’s largest swine herd in 2019, it has created significant export opportunities for the U.S. pork industry. In the United States, recent industry expansion and low prices helped the sector export more pork to China, despite high retaliatory tariffs on U.S. pork
Consolidation in U.S. Agriculture Continues
Creators: name: MacDonald, James M.
name: MacDonald, James M.
Publisher: name: Unknown
Year: 2020
Subjects: subject: Agricultural and Food Policy
subject: Crop Production/Industries
subject: Farm Management
subject: Financial Economics
subject: Livestock Production/Industries
subject: Production Economics
subject: farm economy
subject: crop production
subject: livestock production
subject: cropland

description: Over the last three decades, cropland has increasingly shifted to large operations with 2,000 or more acres. In 1987, 57 percent of cropland acres were operated by midsize farms (100-999 acres), while large farms operated 15 percent of all cropland. By 2017, the midsize farm share had fallen to 33 percent, while the large farm share had grown to 41 percent of all cropland. The consolidation of cropland into larger farms was persistent over time and widespread across most crops and most States. Major consolidation in livestock production continued to affect dairy, hog, and egg production. In contrast, the cow-calf sector, along with associated pasture and rangeland, showed little consolidation.
title: Understanding the geopolitical implications of the Chinese belt and road initiative: what are the consequences for the geographical perspective of the 21st century
Creators: name: Mulholland, Jamie S.
Publisher: name: University of Reading
Year: 2022

description: Grygiel states that “geopolitics is an objective reality, independent of state wishes and interests, that is 
determined by routes and centres of resources,” arguing that “human beings have no choice but to 
adapt themselves to the geographic characteristics of the environment in which they live” (Grygiel, 
2006, pp. 5, 24). This thesis rejects the notion that geography is immutable and that geopolitical change 
is la longue durée. Instead, this thesis argues that through harnessing human agency, state intentions 
and technology, it is possible to change the political and strategic meaning of geography. 
This thesis assesses the geopolitical implications of Chinese policy, and attempts to reveal a willingness 
of the Chinese government to undertake a scale of sustained investment that suggests a complex and 
consciously held long-term policy. Specifically, it will examine China as a case study that exemplifies the 
mutability of geopolitical reality by human agency, the components of which could not be justified by 
the economic elements taken in isolation. All that can be known from this study is their actions. In 
addition, their intentions can only be inferred from the facts on the ground, the related capabilities 
associated with their alliances and the expansion of their military capability. China’s policies are 
informed by geostrategy and attempts to alter the geopolitical reality. 
Rapid development has resulted in sufficient surplus to afford China’s attempt to alter the geopolitical 
reality, with significant investment in mega infrastructure projects funded through newly created 
economic centres. Its actions enhance access to resources and soft power on a scale that eclipses past 
projects that have used big infrastructure as a geopolitical tool, including the Trans-Siberian Railway and 
the Suez and Panama Canals. This study is significant, as it draws from a broad analysis of Beijing’s 
foreign strategy, that provides a context for understanding its behaviour and intent. It concludes with a 
grand strategy informed by geopolitics that seeks to enhance access to resources and create new lines 
of communication to counter potential US containment policies, including sea denial and a challenge to 
the post-1945 economic order.
title: The daylighting benefits of semi-enclosed atrium: based on the case study of Siyuan Centre
Creators: name: Lan, Ruolin
name: Zhang, Yifan
Publisher: name: University of Southampton
Year: 2023

description: This report examined Siyuan Centre's light environment at Nottingham's Jubilee Campus. Analysing building orientation, glazing structure, environmental strategy, visual comfort, and passive energy-saving design met sustainable standardsâdaylight factor, spatial daylight autonomous, and functional daylight illumination. We explored how atrium daylight passively improves indoors. On-site measurement, formula validation, and software simulation tested the atrium and two typical spaces. The test results showed that direct illumination caused glare in the atrium through the wide glazing, exceeding the comfort range. That affected nearby spaces, especially the two open-plan offices that use the atrium for indirect lighting. As an essential light source for them, the atrium provides an uneven and unstable light environment. This study proposed optimisation strategies for shading devices and section design to improve light distribution and reduce glare and simulated space performance after applying them.
Bleomycin A6-loaded anionic liposomes with in situ gel as a new antitumoral drug delivery system
Creators: name: Weiming Ding
name: Yanfang Li
name: Xucheng Hou
name: Guiling Li
Publisher: name: Taylor & Francis
Year: 2014
Subjects: subject: Biochemistry
subject: Space Science
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: The goal is to develop an in situ gel system comprising anionic liposomes (AL) containing bleomycin A6 (BLM A6) dispersed within the thermosensitive in situ gel for sustained release. The results indicated that the gelation temperature decreased due to AL within gel. Similarly, viscosity and mechanical parameters, such as gel strength for gel, could be enhanced by inducing lipid material with negative charge (phosphatidylglycerol) at 37 °C, which provided against corrosion at physiological condition. The in vitro release experiments performed with a dialysis method revealed that in situ gel with AL exhibited the longer drug-release period compared to that with or without nonionic liposomes. An in vivo fluorescence imaging study suggested that the gel with AL loading FITC-BLM A6 stayed in administration site at least for five days. A thermosensitive in situ gel with anionic liposome was a promising carrier for hydrophilic BLM A6, to be used in parenteral delivery system for anti-tumor treatment.
It’s in the Genes: Comparing Dairy Bulls’ Ability To Transmit Traits to Their Daughters
Creators: name: Whitt, Christine
name: Whitt, Christine
Publisher: name: Unknown
Year: 2020
Subjects: subject: Livestock Production/Industries
subject: Research and Development/Tech Change/Emerging Technologies
subject: dairy bulls
subject: genetics
subject: dairy farmers
subject: cattle
subject: beef

description: Dairy bulls pass on different genetic traits to their daughters. Certain traits, like high fat content, can influence how much milk revenue a daughter produces in her lifetime. USDA’s Economic Research Service and Cornell University researchers used 2017 trait data from a dataset of more than 400 Holstein bulls to estimate the technical, revenue, allocative, and profit efficiency of each bull relative to its peers.
Neuropsychological Profile of Children, Adolescents and Adults Experiencing Maltreatment: A Meta-analysis
Creators: name: Masson, Marjolaine
name: Eve-Line Bussières
name: East-Richard, Caroline
name: R-Mercier, Alexandra
name: Cellard, Caroline
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Neuroscience
subject: Cell Biology
subject: Medicine

description: Objective: Few studies have attempted to describe the range of cognitive impairments affecting people who have experienced child maltreatment. The aim of this meta-analysis was to examine the neuropsychological profile of these people and to determine the cognitive impacts of maltreatment from childhood to adulthood. Method: Fifty-two publications from 1970 to 2013 were included. Results: The affected cognitive domains were working memory (g = −.65), attention (g = −.63), intelligence (g = −.56) and speed of processing (g = −.49). The impact of maltreatment was greater in young children (g = −.71) and less pronounced in adults (g = −.26). Conclusions: These results suggest that exposure to maltreatment has an impact on specific cognitive processes, regardless of age.
title: Attestation pour le patient no 72
Creators: name: Leibowitch, Jacques (1942-2020)
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Lettre de Jacques Leibowitch résumant l'histoire du traitement anti-vih du patient, ayant pour but, une fois signée et approuvée, de servir d'attestation de leur consentement à emprunter une voie médicamenteuse non validée (allégée).