cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 2 of Quantification, description and international comparison of antimicrobial use on Irish pig farms
Creators: name: O’Neill, Lorcan
name: Costa, Maria Rodrigues Da
name: Leonard, Finola C.
name: Gibbons, James
name: Díaz, Julia Adriana Calderón
name: McCutcheon, Gerard
name: Manzanilla, Edgar García
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine

description: Additional file 2: Supplementary Table 1. Breakdown of antimicrobial use by stage of production. Supplementary Figure 1. Numbers of antimicrobials used in medicated feed in diets for growing pigs on 67 Irish pig farms during 2016. Supplementary Table 2. Prophylactic AMU in oral remedies other than premix and injectable preparations.
(102910) Arthur C Lloyd
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(102909) Gertrude Eleanor Lloyd
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Enhanced bioactivity of silybin B methylation products
Creators: name: Sy-Cordero, Arlene A.
name: Runyon, Scott P.
name: Brantley, Scott J.
name: Agarwal, Rajesh
name: Wani, Mansukh C.
name: Graf, Tyler N.
name: Paine, Mary F.
name: Kroll, David J.
name: Polyak, Stephen J.
name: Oberlies, Nicholas H.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Flavonolignans from milk thistle (Silybum marianum) have been investigated for their cellular modulatory properties, including cancer chemoprevention and hepatoprotection, as an extract (silymarin), as partially purified mixtures (silibinin and isosilibinin), and as pure compounds (a series of seven isomers). One challenge with the use of these compounds in vivo is their relatively short half-life due to conjugation, particularly glucuronidation. In an attempt to generate analogues with improved in vivo properties, particularly reduced metabolic liability, a semi-synthetic series was prepared in which the hydroxy groups of silybin B were alkylated. A total of five methylated analogues of silybin B were synthesized using standard alkylation conditions (dimethyl sulfate and potassium carbonate in acetone), purified using preparative HPLC, and elucidated via spectroscopy and spectrometry. Of the five, one was monomethylated (3), one was dimethylated (4), two were trimethylated (2 and 6), and one was tetramethylated (5). The relative potency of all compounds was determined in a 72 hr growth-inhibition assay against a panel of three prostate cancer cell lines (DU-145, PC-3, and LNCaP) and a human hepatoma cell line (Huh7.5.1) and compared to natural silybin B. Compounds also were evaluated for inhibition of both cytochrome P450 2C9 (CYP2C9) activity in human liver microsomes and hepatitis C virus infection in Huh7.5.1 cells. The monomethyl and dimethyl analogues were shown to have enhanced activity in terms of cytotoxicity, CYP2C9 inhibitory potency, and antiviral activity (up to 6-fold increased potency) compared to the parent compound, silybin B. In total, these data suggested that methylation of flavonolignans can increase bioactivity.
Search for α3β2/3γ2 subtype selective ligands that are stable on human liver microsomes
Creators: name: Rallapalli, Sundari K.
name: Cook, James M.
name: Johnson, Yun Teng
name: Majumder, Samarpan
name: Johnson Jr., Edward Merle
name: Varagic, Zdravko
name: Wang, Zhi Jian
name: Rowlett, James K.
name: Sieghart, Werner
name: Ng, Hanna
name: Namjoshi, Ojas A.
name: Roth, Bryan L.
name: Ramerstorfer, Joachim
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Selective modulation of specific benzodiazepine receptor (BzR) gamma amino butyric acid-A (GABAA) receptor ion channels has been identified as an important method for separating out the variety of pharmacological effects elicited by BzR-related drugs. Importantly, it has been demonstrated that both α2β(2/3)γ2 (α2BzR) and α3BzR (and/or α2/α3) BzR subtype selective ligands exhibit anxiolytic effects with little or no sedation. Previously we have identified several such ligands; however, three of our parent ligands exhibited significant metabolic liability in rodents in the form of a labile ester group. Here eight analogs are reported which were designed to circumvent this liability by utilizing a rational replacement of the ester moiety based on medicinal chemistry precedents. In a metabolic stability study using human liver microsomes, four compounds were found to undergo slower metabolic transformation, as compared to their corresponding ester analogs. These compounds were also evaluated in in vitro binding as well as efficacy assays. Additionally, bioisostere 11 was evaluated in a rodent model of anxiety. It exhibited anxiolytic activity at doses of 10 and 100 mg/kg and was devoid of sedative properties.
Partial spin polarization of conductance in vertical bi-layer nanowire with rectangular and smooth lateral confinement potential
Creators: name: Chwiej, T.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We simulate the electron transport in vertical bi-layer nanowire which can be fabricated in molecular beam epitaxy process with lateral confinement potential formed by means of cleaved overgrowth or surface oxidization methods giving rectangular and smooth side confinement, respectively. In calculations we take into account interaction between charge carriers using DFT within local spin density approximation. If magnetic field is perpendicular to the wire axis, pseudogaps are opened in energy dispersion relation E(k) what in conjunction with spin Zeeman shift of spin-up and spin-down subbands allows for quite high spin polarization of conductance. We find that in nanowire with rectangular lateral confinement potential, electron density has two maximums localized at wire edges in each layers. This modificates strongly all magnetosubbands giving up to four energy minimums in lowest subband and considerably diminishes widths of pseudogaps what translates into low maximal spin polarization of conductance, not exceeding $40\%$. This drawback is absent in wire with smooth lateral confinement. However, in order to gain a large spin polarization simultaneous tuning of magnetic field as well as the Fermi energies in both layers of nanowire are required.
Clusters of heavy particles in two-dimensional Keplerian turbulence
Creators: name: Gerosa, Fabiola Antonietta
name: Meheut, Héloïse
name: Bec, Jérémie
Publisher: name: arXiv
Year: 2022
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Chaotic Dynamics (nlin.CD)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: Protoplanetary disks are gaseous systems in Keplerian rotation around young stars, known to be turbulent. They include a small fraction of dust from which planets form. In the incremental scenario for planet growth, the formation of kilometer-size objects (planetesimals) from pebbles is a major open question. Clustering of particles is necessary for solids to undergo a local gravitational collapse. To address this question, the dynamic of inertial particles in turbulent flows with Keplerian rotation and shear is studied. Two-dimensional direct numerical simulations are performed to explore systematically two physical parameters: the rotation rate, which depends on the distance to the star, and the particle response time, which relates to their size. Shear is found to drastically affect the characteristics of the turbulent flow destroying cyclones and favoring the survival of anticyclones. Faster Keplerian rotation enhances clustering of particles. For intermediate sizes, particles concentrate in anticyclones. These clusters form in a hierarchical manner and merge together with time. For other parameter values, solids concentrate on fractal sets that get more singular with rotation. The mass distribution of particles is then found to be multifractal with small dimensions at large orders, intriguing for triggering their gravitational collapse. Such results are promising for a precise description and better understanding of planetesimal formation.
description: 16 pages, 21 figures
No signaling and strong subadditivity condition for tomographic q-entropy of single qudit states
Creators: name: Chernega, V. N.
name: Man'ko, O. V.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: The single qudit state tomograms are shown to have the no signaling property. The known and new entropic and information inequalities for Shannon, von Neumann and q-entropies of the composite and noncomposite systems characterizing correlations in these systems are discussed. The spin tomographic probability distributions determining the single qudit states are demonstrated to satisfy the strong subadditivity condition for Tsallis q-entropy. Examples of the new entropic inequalities for q-entropy are considered for qudits with j = 5=2, j = 7=2.
description: to be published in Special Issue of Physica Scripta
Toric $G$-Fano Threefolds
Creators: name: Sarikyan, Arman
Publisher: name: arXiv
Year: 2019
Subjects: subject: Algebraic Geometry (math.AG)
subject: FOS: Mathematics

description: We classify toric Fano threefolds having at worst terminal singularities such that a rank of a $G$-invariant part of a class group equals one, where $G$ is a group acting on the variety by automorphisms.
Field-linked resonances of polar molecules
Creators: name: Chen, Xing-Yan
name: Schindewolf, Andreas
name: Eppelt, Sebastian
name: Bause, Roman
name: Duda, Marcel
name: Biswas, Shrestha
name: Karman, Tijs
name: Hilker, Timon
name: Bloch, Immanuel
name: Luo, Xin-Yu
Publisher: name: arXiv
Year: 2022
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Atomic Physics (physics.atom-ph)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Scattering resonances are an essential tool for controlling interactions of ultracold atoms and molecules. However, conventional Feshbach scattering resonances, which have been extensively studied in various platforms, are not expected to exist in most ultracold polar molecules due to the fast loss that occurs when two molecules approach at a close distance. Here, we demonstrate a new type of scattering resonances that is universal for a wide range of polar molecules. The so-called field-linked resonances occur in the scattering of microwave-dressed molecules due to stable macroscopic tetramer states in the intermolecular potential. We identify two resonances between ultracold ground-state sodium-potassium molecules and use the microwave frequencies and polarizations to tune the inelastic collision rate by three orders of magnitude, from the unitary limit to well below the universal regime. The field-linked resonance provides a tuning knob to independently control the elastic contact interaction and the dipole-dipole interaction, which we observe as a modification in the thermalization rate. Our result provides a general strategy for resonant scattering between ultracold polar molecules, which paves the way for realizing dipolar superfluids and molecular supersolids as well as assembling ultracold polyatomic molecules.
Synthesis and biological evaluation of N-alkyl-N-(4-methoxyphenyl)pyridin-2-amines as a new class of tubulin polymerization inhibitors
Creators: name: Lee, Kuo Hsiung
name: Xie, Lan
name: Morris-Natschke, Susan L.
name: Ohkoshi, Emika
name: Hamel, Ernest
name: Bastow, Kenneth F.
name: Wang, Xiao Feng
name: Wang, Sheng Biao
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Based on our prior antitumor hits, 32 novel N-alkyl-N-substituted phenylpyridin-2-amine derivatives were designed, synthesized and evaluated for cytotoxic activity against A549, KB, KBVIN, and DU145 human tumor cell lines (HTCL). Subsequently, three new leads (6a, 7g, and 8c) with submicromolar GI50 values of 0.19 to 0.41 μM in the cellular assays were discovered, and these compounds also significantly inhibited tubulin assembly (IC50 1.4–1.7 μM) and competitively inhibited colchicine binding to tubulin with effects similar to those of the clinical candidate CA-4 in the same assays. These promising results indicate that these tertiary diarylamine derivatives represent a novel class of tubulin polymerization inhibitors targeting the colchicine binding site and showing significant anti-proliferative activity.
The impact of quark masses on pQCD thermodynamics
Creators: name: Graf, Thorben
name: Schaffner-Bielich, Juergen
name: Fraga, Eduardo S.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We present results for several thermodynamic quantities within the next-to-leading order calculation of the thermodynamic potential in perturbative QCD at finite temperature and chemical potential including non-vanishing quark masses. These results are compared to lattice data and to higher-order optimized perturbative calculations to investigate the trend brought about by mass corrections.
description: V2: Major modifications; 12 pages, 13 figures
Cytotoxic cardiac glycosides and coumarins from Antiaris toxicaria
Creators: name: Wu, Tian Shung
name: Shi, Li Shian
name: Morris-Natschke, Susan L.
name: Kuo, Sheng Chu
name: Lee, Kuo Hsiung
name: Sun, Han Dong
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Eight new cardiac glycosides/aglycones (antiaritoxiosides A–G, 1–7, and antiarotoxinin B, 8), two new coumarins (anticarins A–B, 41–42), and two new flavanones (antiarones L–K, 43–44) were isolated from trunk bark of Antiaris toxicaria together with 53 known compounds. The new structures were established by extensive analysis of spectroscopic data. Compound 1 (10-carboxy and 3α-hydroxy) and compounds 3–6 (10-hydroxy) contain unique substituents that are rarely found in cardiac glycosides. The cytotoxic effects of isolated compounds against ten human cancer cell lines, KB, KB-VIN, A549, MCF-7, U-87-MG, PC-3, 1A9, CAKI-1, HCT-9 and S-KMEL-2, were tested using the sulforhodamine B assay. Five compounds (12, 16, 20, 22, and 31) showed significant cytotoxicity against all ten cancer cell lines, with notable potency at the ng/mL level against some cell lines, which merits further development as clinical trial candidates.
Additional file 3 of Ontogeny, species identity, and environment dominate microbiome dynamics in wild populations of kissing bugs (Triatominae)
Creators: name: Brown, Joel J.
name: Rodríguez-Ruano, Sonia M.
name: Anbu Poosakkannu
name: Batani, Giampiero
name: Schmidt, Justin O.
name: Roachell, Walter
name: Zima, Jan
name: Hypša, Václav
name: Nováková, Eva
Publisher: name: figshare
Year: 2020
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional File 3: Results of ordination analyses based on 'basic' and 'decontam' datasets.
Dark Matter and Gauged Flavor Symmetries
Creators: name: Bishara, Fady
name: Greljo, Admir
name: Kamenik, Jernej F.
name: Stamou, Emmanuel
name: Zupan, Jure
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We investigate the phenomenology of flavored dark matter (DM). DM stability is guaranteed by an accidental ${\mathcal Z}_3$ symmetry, a subgroup of the standard model (SM) flavor group that is not broken by the SM Yukawa interactions. We consider an explicit realization where the quark part of the SM flavor group is fully gauged. If the dominant interactions between DM and visible sector are through flavor gauge bosons, as we show for Dirac fermion flavored DM, then the DM mass is bounded between roughly $0.5$ TeV and $5$ TeV if the DM multiplet mass is split only radiatively. In general, however, no such relation exists. We demonstrate this using scalar flavored DM where the main interaction with the SM is through the Higgs portal. For both cases we derive constraints from flavor, cosmology, direct and indirect DM detection, and collider searches.
description: 46 pages, 16 figures
IRS-Assisted RF-powered IoT Networks:System Modeling and Performance Analysis
Creators: name: Sun, Hongguang
name: Zhao, Zelun
name: Cheng, Hu
name: Lyu, Jiangbin
name: Wang, Xijun
name: Zhang, Yan
name: Quek, Tony Q. S.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Emerged as a promising solution for future wireless communication systems, intelligent reflecting surface (IRS) is capable of reconfiguring the wireless propagation environment by adjusting the phase-shift of a large number of reflecting elements. To quantify the gain achieved by IRSs in the radio frequency (RF) powered Internet of Things (IoT) networks, in this work, we consider an IRS-assisted cellular-based RFpowered IoT network, where the cellular base stations (BSs) broadcast energy signal to IoT devices for energy harvesting (EH) in the charging stage, which is utilized to support the uplink (UL) transmissions in the subsequent UL stage. With tools from stochastic geometry, we first derive the distributions of the average signal power and interference power which are then used to obtain the energy coverage probability, UL coverage probability, overall coverage probability, spatial throughput and power efficiency, respectively. With the proposed analytical framework, we finally evaluate the effect on network performance of key system parameters, such as IRS density, IRS reflecting element number, charging stage ratio, etc. Compared with the conventional RF-powered IoT network, IRS passive beamforming brings the same level of enhancement in both energy coverage and UL coverage, leading to the unchanged optimal charging stage ratio when maximizing spatial throughput.
description: 32 pages, 11 figures, submitted to IEEE Transactions on Communications
Additional file 4 of Ontogeny, species identity, and environment dominate microbiome dynamics in wild populations of kissing bugs (Triatominae)
Creators: name: Brown, Joel J.
name: Rodríguez-Ruano, Sonia M.
name: Anbu Poosakkannu
name: Batani, Giampiero
name: Schmidt, Justin O.
name: Roachell, Walter
name: Zima, Jan
name: Hypša, Václav
name: Nováková, Eva
Publisher: name: figshare
Year: 2020
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional File 4: Sample set phylogenetic background inferred from coxB sequences.
Design and synthesis of novel spin-labeled camptothecin derivatives as potent cytotoxic agents
Creators: name: Lee, Kuo Hsiung
name: Goto, Masuo
name: Morris-Natschke, Susan L.
name: Wu, Xiao Bing
name: Zhu, Gao Xiang
name: Wu, Dan
name: Zhao, Xiao Bo
name: Liu, Ying Qian
name: Wang, Mei Juan
name: Song, Zi Long
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: In our continuing search for natural product-based spin-labeled antitumor drugs, 20 novel spin-labeled camptothecin derivatives were synthesized via a Cu-catalyzed one pot reaction and evaluated for cytotoxicity against four human tumor cell lines (A-549, MDA-MB-231, KB, and KBvin). Eighteen of the target compounds (9a, 9b, 9d–9k, 9m–9t) exhibited significant in vitro antiproliferative activity against these four tested tumor cell lines. Compounds 9e and 9j (IC50 0.057 and 0.072 μM, respectively) displayed the greatest cytotoxicity against the multidrug-resistant (MDR) KBvin cell line and merit further development into preclinical and clinical drug candidates for treating cancer including MDR phenotype.
Design, synthesis and cytotoxic activity of novel sulfonylurea derivatives of podophyllotoxin
Creators: name: Lee, Kuo Hsiung
name: Liu, Ying Qian
name: Nan, Xiang
name: Tian, Jing
name: Yang, Liu
name: Morris-Natschke, Susan L.
name: Wang, Li Ting
name: Wang, Mei Juan
name: Zhang, Zhi Jun
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Three series of novel sulfonylurea podophyllotoxin derivatives were designed, synthesized, and evaluated for in vitro cytotoxicity against four tumor cell lines (A-549, DU-145, KB and KBvin). Compounds 14c (IC50: 1.41–1.76 μM) and 14e (IC50: 1.72–2.01 μM) showed superior cytotoxic activity compared with etoposide (IC50: 2.03– >20μM), a clinically available anticancer drug. Significantly, most of the compounds exhibited comparable cytotoxicity against the drug-resistant tumor cell line KBvin, while etoposide lost activity completely. Preliminary structure-activity relationship (SAR) correlations indicated that the 4′-O-methyl functionality in podophyllotoxin analogues may be essential to maintain cytotoxic activity, while an arylsulfonylurea side chain at podophyllotoxin’s 4β position can significantly improve cytotoxic activity.
Additional file 8 of Ontogeny, species identity, and environment dominate microbiome dynamics in wild populations of kissing bugs (Triatominae)
Creators: name: Brown, Joel J.
name: Rodríguez-Ruano, Sonia M.
name: Anbu Poosakkannu
name: Batani, Giampiero
name: Schmidt, Justin O.
name: Roachell, Walter
name: Zima, Jan
name: Hypša, Václav
name: Nováková, Eva
Publisher: name: figshare
Year: 2020
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional File 8: Bartonella phylogenetic analysis of gltA sequences retrieved from T. rubida.
(102905) Henry Britten Cox
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Additional file 2 of Ontogeny, species identity, and environment dominate microbiome dynamics in wild populations of kissing bugs (Triatominae)
Creators: name: Brown, Joel J.
name: Rodríguez-Ruano, Sonia M.
name: Anbu Poosakkannu
name: Batani, Giampiero
name: Schmidt, Justin O.
name: Roachell, Walter
name: Zima, Jan
name: Hypša, Václav
name: Nováková, Eva
Publisher: name: figshare
Year: 2020
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional File 2: Methodological Supplement for 18S rRNA gene blocking primer design and validation
(102904) Ellen Selena Withers
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Discovery of novel antitumor dibenzocyclooctatetraene derivatives and related biphenyls as potent inhibitors of NF-κB signaling pathway
Creators: name: Morris-Natschke, Susan L.
name: Lai, Chin Yu
name: Wang, Sheng Biao
name: Wang, Li Ting
name: Lee, Kuo Hsiung
name: Xie, Lan
name: Ohkoshi, Emika
name: Yu, Le
name: Gu, Chunping
name: Liu, Shuwen
name: Yu, Fang Lin
name: He, Xiao Yang
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Several dibenzocyclooctatetraene derivatives (5-7) and related biphenyls (8-11) were designed, synthesized, and evaluated for inhibition of cancer cell growth and the NF-κB signaling pathway. Compound 5a, a dibenzocyclooctatetraene succinimide, was discovered as a potent inhibitor of the NF-κB signaling pathway with significant antitumor activity against several human tumor cell lines (GI50 1.38–1.45 μM) and was more potent than paclitaxel against the drug-resistant KBvin cell line. Compound 5a also inhibited LPS-induced NF-κB activation in RAW264.7 cells with an IC50 value of 0.52 μM, prevented IκB-α degradation and p65 nuclear translocation, and suppressed LPS-induced NO production in a dose-dependent manner. The antitumor data in cellular assays indicated that relative positions and types of substituents on the dibenzocyclooctatetraene or acyclic biphenyl as well as torsional angles between the two phenyls are of primary importance to antitumor activity.
The Effect of Non-minimally Coupled Scalar Field on Gravitational Waves from First-order Vacuum Phase Transitions
Creators: name: Arapoğlu, A. Savaş
name: Yükselci, A. Emrah
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We investigate first-order vacuum phase transitions in the presence of a non-minimally coupled scalar field starting with the coupling effect on the initial dynamics of phase transitions by defining an effective potential for the scalar field and then performing three dimensional numerical simulations to observe any possible distinction in gravitational wave power spectrum. Although we give a description of the model with the expanding background, in this particular paper, we exclude the scale factor contribution since we primarily focus on the immediate impact of the non-minimal coupling at initial phases of the transition. Even in this case we found that this modification has discernible effect on the power spectrum of the gravitational wave energy density.
description: 18 pages, 8 figures, appendix added, typos corrected, matches with the published version
The periodic integral orbits of polynomial recursions with integer coefficients
Creators: name: Sedaghat, Hassan
Publisher: name: arXiv
Year: 2019
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: 39A23

description: We show that polynomial recursions $x_{n+1}=x_{n}^{m}-k$ where $k,m$ are integers and $m$ is positive have no nontrivial periodic integral orbits for $m\geq3$. If $m=2$ then the recursion has integral two-cycles for infinitely many values of $k$ but no higher period orbits. We also show that these statements are true for all quadratic recursions.
description: 19 pages, 2 figures
Schwarzschild spacetime under generalised Gullstrand-Painlevé slicing
Creators: name: MacLaurin, Colin
Publisher: name: arXiv
Year: 2019
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We investigate a foliation of Schwarzschild spacetime determined by observers freely falling in the radial direction. This is described using a generalisation of Gullstrand-Painlevé coordinates which allows for any possible radial velocity. This foliation provides a contrast with the usual static foliation implied by Schwarzschild coordinates. The $3$-dimensional spaces are distinct for the static and falling observers, so the embedding diagrams, spatial measurement, simultaneity, and time at infinity are also distinct, though the $4$-dimensional spacetime is unchanged. Our motivation is conceptual understanding, to counter Newton-like viewpoints. In future work, this alternate foliation may shed light on open questions regarding quantum fields, analogue gravity, entropy, energy, and other quantities. This article is aimed at experienced relativists, whereas a forthcoming series is intended for a general audience of physicists, mathematicians, and philosophers.
description: 21 pages, 5 figures, to appear as chapter 9 in Cacciatori, G\"uneysu, and Pigola, eds. (c. 2019), Einstein equations: Physical and mathematical aspects of general relativity
(102903) Hilda Nellie Cox
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Identification of a new selective dopamine D4 receptor ligand
Creators: name: Ofori, Edward
name: Zhu, Xue Y.
name: Sampson, Dinithia
name: Eyunni, Suresh V.K.
name: Etukala, Jagan R.
name: Ablordeppey, Seth Y.
name: Roth, Bryan L.
name: Setola, Vincent
name: Bricker, Barbara
name: Lamango, Nazarius S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The dopamine D4 receptor has been shown to play key roles in certain CNS pathologies including addiction to cigarette smoking. Thus, selective D4 ligands may be useful in treating some of these conditions. Previous studies in our laboratory have indicated that the piperazine analog of haloperidol exhibits selective and increased affinity to the DAD4 receptor subtype, in comparison to its piperidine analog. This led to further exploration of the piperazine moiety to identify new agents that are selective at the D4 receptor. Compound 27 (KiD4 = 0.84 nM) was the most potent of the compounds tested. However, it only had moderate selectivity for the D4 receptor. Compound 28 (KiD4 = 3.9 nM) while not as potent, was more discriminatory for the D4 receptor subtype. In fact, compound 28 has little or no binding affinity to any of the other four DA receptor subtypes. In addition, of the 23 CNS receptors evaluated, only two, 5HT1AR and 5HT2BR, have binding affinity constants better than 100 nM (Ki < 100 nM). Compound 28 is a potentially useful D4-selective ligand for probing disease treatments involving the D4 receptor, such as assisting smoking cessation, reversing cognitive deficits in schizophrenia and treating erectile dysfunction. Thus, further optimization, functional characterization and evaluation in animal models may be warranted.
Additional file 5 of Ontogeny, species identity, and environment dominate microbiome dynamics in wild populations of kissing bugs (Triatominae)
Creators: name: Brown, Joel J.
name: Rodríguez-Ruano, Sonia M.
name: Anbu Poosakkannu
name: Batani, Giampiero
name: Schmidt, Justin O.
name: Roachell, Walter
name: Zima, Jan
name: Hypša, Václav
name: Nováková, Eva
Publisher: name: figshare
Year: 2020
Subjects: subject: Microbiology
subject: FOS: Biological sciences

description: Additional File 5: Microbiome ontogenetic shift in other Triatoma sp.
Clarifying spatial distance measurement
Creators: name: MacLaurin, Colin
Publisher: name: arXiv
Year: 2019
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We examine length measurement in curved spacetime, based on the 1+3-splitting of a local observer frame. This situates extended objects within spacetime, in terms of a given coordinate which serves as an external reference. The radar metric is shown to coincide with the spatial projector, but these only give meaningful results on the observer's 3-space, where they reduce to the metric. Examples from Schwarzschild spacetime are given.
description: 6 pages, 0 figures, submitted to the proceedings of the 2018 Marcel Grossmann conference, Rome. v2 has minor rewording and typo corrections
The Fifth Catalogue of Nearby Stars (CNS5)
Creators: name: Golovin, Alex
name: Reffert, Sabine
name: Just, Andreas
name: Jordan, Stefan
name: Vani, Akash
name: Jahreiß, Hartmut
Publisher: name: arXiv
Year: 2022
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: We present the compilation of the Fifth Catalogue of Nearby Stars (CNS5), based on astrometric and photometric data from Gaia EDR3 and Hipparcos, and supplemented with parallaxes from ground-based astrometric surveys carried out in the infrared. The aim of the CNS5 is to provide the most complete sample of objects in the solar neighbourhood. For all known stars and brown dwarfs in the 25 pc sphere around the Sun, basic astrometric and photometric parameters are given. Furthermore, we provide the colour-magnitude diagram and various luminosity functions of the stellar content in the solar neighbourhood, and characterise the completeness of the CNS5 catalogue. We compile a sample of stars and brown dwarfs which most likely are located within 25 pc of the Sun, taking space-based parallaxes from Gaia EDR3 and Hipparcos as well as ground-based parallaxes from Best et al. (2021), Kirkpatrick et al. (2021), and from the CNS4 into account. We develop a set of selection criteria to clean the sample from spurious sources. Furthermore, we show that effects of blending in the Gaia photometry, which affect mainly the faint and red sources in Gaia, can be mitigated, to reliably place those objects in a colour-magnitude diagram. We also assess the completeness of the CNS5 using a Kolmogorov-Smirnov test and derive observational optical and mid-infrared luminosity functions for the main-sequence stars and white dwarfs in the solar neighbourhood. The CNS5 contains 5931 objects, including 5230 stars (4946 main-sequence stars, 20 red giants and 264 white dwarfs) and 701 brown dwarfs. We find that the CNS5 catalogue is statistically complete down to 19.7 mag in G-band and 11.8 mag in W1-band absolute magnitudes, corresponding to a spectral type of L8.
description: Accepted for publication in A&A. Catalogue available at https://dc.g-vo.org/CNS5
(102901) Harold Walter Peaty
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Chimeric derivatives of functionalized amino acids and α-aminoamides: Compounds with anticonvulsant activity in seizure models and inhibitory actions on central, peripheral, and cardiac isoforms of voltage-gated sodium channels
Creators: name: Yang, Xiao Fang
name: Khanna, Rajesh
name: Torregrosa, Robert
name: Cummins, Theodore R.
name: Dustrude, Erik T.
name: Kohn, Harold
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Six novel 3″-substituted (R)-N-(phenoxybenzyl) 2-N-acetamido-3-methoxypropionamides were prepared and then assessed using whole-cell, patch-clamp electrophysiology for their anticonvulsant activities in animal seizure models and for their sodium channel activities. We found compounds with various substituents at the terminal aromatic ring that had excellent anticonvulsant activity. Of these compounds, (R)-N-4′-((3″-chloro)phenoxy)benzyl 2-N-acetamido-3-methoxypropionamide ((R)-5) and (R)-N-4′-((3″-trifluoromethoxy)phenoxy)benzyl 2-N-acetamido-3-methoxypropionamide ((R)-9) exhibited high protective indices (PI = TD50/ED50) comparable with many antiseizure drugs when tested in the maximal electroshock seizure test to mice (intraperitoneally) and rats (intraperitoneally, orally). Most compounds potently transitioned sodium channels to the slow-inactivated state when evaluated in rat embryonic cortical neurons. Treating HEK293 recombinant cells that expressed hNav1.1, rNav1.3, hNav1.5, or hNav1.7 with (R)-9 recapitulated the high levels of sodium channel slow inactivation.
On the superstring-inspired quantum correction to the Starobinsky model of inflation
Creators: name: Ketov, Sergei V.
name: Pozdeeva, Ekaterina O.
name: Vernov, Sergey Yu.
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Superstring/M-theory is the theory of quantum gravity that can provide the UV-completion to viable inflation models. We modify the Starobinsky inflation model by adding the Bel-Robinson tensor $T^{μνλρ}$ squared term proposed as the leading quantum correction inspired by superstring theory. The $(R+\frac{1}{6m^2}R^2 -\fracβ{8m^6}T^2)$ model under consideration has two parameters: the inflaton mass $m$ and the string-inspired positive parameter $β$. We derive the equations of motion in the Friedmann-Lemaitre-Robertson-Walker universe and investigate its solutions. We find the physical bounds on the value of the parameter $β$ by demanding the absence of ghosts and consistency of the derived inflationary observables with the measurements of the cosmic microwave background radiation.
description: 24 pages, 5 figures, LaTeX; the version to appear in JCAP
Additional file 1 of Using heat maps to identify areas prone to violence against women in the public sphere
Creators: name: Royo, Margarita Garfias
name: Parikh, Priti
name: Belur, Jyoti
Publisher: name: figshare
Year: 2020
Subjects: subject: Medicine
subject: Cell Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer

description: Additional file 1. Observations and visual data checklist.
Cosmic cable
Creators: name: MacLaurin, Colin
Publisher: name: arXiv
Year: 2019
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: I investigate the relativistic mechanics of an extended "cable" in an arbitrary static, spherically symmetric spacetime. Such hypothetical bodies have been proposed as tests of energy and thermodynamics: by lowering objects toward a black hole, scooping up Hawking radiation, or mining energy from the expansion of the universe. I review existing work on stationary cables, which demonstrates an interesting "redshift" of tension, and extend to a case of rigid motion. By using a partly restrained cable to turn a turbine, the energy harvested is up to the equivalent of the cable's rest mass, concurring with the quasistatic case. Still, the total Killing energy of the system is conserved.
description: 6 pages, 0 figures, submitted to the proceedings of the 2018 Marcel Grossmann conference in Rome
Discovery of Mer kinase inhibitors by virtual screening using Structural Protein–Ligand Interaction Fingerprints
Creators: name: Jayakody, C.
name: Wang, X.
name: Janzen, W.
name: Kireev, D.
name: Frye, S.
name: Stashko, M.
name: Da, C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: Mer is a receptor tyrosine kinase implicated in acute lymphoblastic leukemia (ALL), the most common malignancy in children. The currently available data provide a rationale for development of Mer kinase inhibitors as cancer therapeutics that can target both cell autologous and immune-modulatory anti-tumor effects. We have previously reported several series of potent Mer inhibitors and the objective of the current report is to identify a chemically dissimilar back-up series that might circumvent potential, but currently unknown, flaws inherent to the lead series. To this end, we virtually screened a database of ∼3.8 million commercially available compounds using high-throughput docking followed by a filter involving Structural Protein-Ligand Interaction Fingerprints (SPLIF). SPLIF permits a quantitative assessment of whether a docking pose interacts with the protein target similarly to an endogenous or known synthetic ligand, and therefore helps to improve both sensitivity and specificity with respect to the docking score alone. Of the total of 62 experimentally tested compounds, 15 demonstrated reliable dose-dependent responses in the Mer in vitro kinase activity assay with inhibitory potencies ranging from 0.46 μM to 9.9 μM.
Permutation blocking path integral Monte Carlo: A highly efficient approach to the simulation of strongly degenerate non-ideal fermions
Creators: name: Dornheim, Tobias
name: Groth, Simon
name: Filinov, Alexey
name: Bonitz, Michael
Publisher: name: arXiv
Year: 2015
Subjects: subject: Quantum Gases (cond-mat.quant-gas)
subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: Correlated fermions are of high interest in condensed matter (Fermi liquids, Wigner molecules), cold atomic gases and dense plasmas. Here we propose a novel approach to path integral Monte Carlo (PIMC) simulations of strongly degenerate non-ideal fermions at finite temperature by combining a fourth-order factorization of the density matrix with antisymmetric propagators, i.e., determinants, between all imaginary time slices. To efficiently run through the modified configuration space, we introduce a modification of the widely used continuous space worm algorithm, which allows for an efficient sampling at arbitrary system parameters. We demonstrate how the application of determinants achieves an effective blocking of permutations with opposite signs, leading to a significant relieve of the fermion sign problem. To benchmark the capability of our method regarding the simulation of degenerate fermions, we consider multiple electrons in a quantum dot and compare our results with other ab initio techniques, where they are available. The present permutation blocking path integral Monte Carlo approach allows us to obtain accurate results even for $N=20$ electrons at low temperature and arbitrary coupling, where no other ab initio results have been reported, so far.
(102900) Lillian Matilda Peaty
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
First bromine doped cryogenic implosion at the National Ignition Facility
Creators: name: Hayes, A. C.
name: Kyrala, G.
name: Gooden, M.
name: Wilhelmy, J. B.
name: Kot, L.
name: Volegov, P.
name: Wilde, C.
name: Haines, B.
name: Jungman, Gerard
name: Rundberg, R. S.
name: Wilson, D. C.
name: Velsko, C.
name: Cassata, W.
name: Henry, E.
name: Yeamans, C.
name: Cerjan, C.
name: Ma, T.
name: Doppner, T.
name: Nikroo, A.
name: Hurricane, O.
name: Callahan, D.
name: Hinkel, D.
name: Schneider, D.
name: Bachmann, B.
name: Graziani, F.
name: Chen, K. C.
name: Kong, C.
name: Huang, H.
name: Crippen, J. W.
name: Ratledge, M.
name: Rice, N. G.
name: Farrell, M. P.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: Nuclear Experiment (nucl-ex)
subject: FOS: Physical sciences

description: We report on the first experiment dedicated to the study of nuclear reactions on dopants in a cryogenic capsule at the National Ignition Facility (NIF). This was accomplished using bromine doping in the inner layers of the CH ablator of a capsule identical to that used in the NIF shot N140520. The capsule was doped with 3$\times$10$^{16}$ bromine atoms. The doped capsule shot, N170730, resulted in a DT yield that was 2.6 times lower than the undoped equivalent. The Radiochemical Analysis of Gaseous Samples (RAGS) system was used to collect and detect $^{79}$Kr atoms resulting from energetic deuteron and proton ion reactions on $^{79}$Br. RAGS was also used to detect $^{13}$N produced dominantly by knock-on deuteron reactions on the $^{12}$C in the ablator. High-energy reaction-in-flight neutrons were detected via the $^{209}$Bi(n,4n)$^{206}$Bi reaction, using bismuth activation foils located 50 cm outside of the target capsule. The robustness of the RAGS signals suggest that the use of nuclear reactions on dopants as diagnostics is quite feasible.