cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 1 of Characterization of newly isolated thermotolerant bacterium Cupriavidus sp. CB15 from composting and its ability to produce polyhydroxyalkanoate from glycerol
Creators: name: Yootoum, Anuyut
name: Jantanasakulwong, Kittisak
name: Rachtanapun, Pornchai
name: Moukamnerd, Churairat
name: Chaiyaso, Thanongsak
name: Pumas, Chayakorn
name: Tanadchangsaeng, Nuttapol
name: Watanabe, Masanori
name: Fukui, Toshiaki
name: Insomphun, Chayatip
Publisher: name: figshare
Year: 2023
Subjects: subject: Space Science
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology

description: Additional file 1: Table S1 Basic properties of compost samplings.
Additional file 1 of Spatial variation of cardiovascular mortality in Cali, Colombia, between 2010 and 2017
Creators: name: Murillo, Luisa M.
name: Ramírez, Carolina
name: Andrade-Bejarano, Mercedes
name: Perlaza, Guillermo
name: Barrera, Lena
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics

description: Additional file 1: Table S1. Characteristics of deaths due to cardiovascular diseases registered in Cali between 2010 and 2017. Table S2. Characteristics of death from districts 1, 14 and 21 in Cali, between 2010 and 2017.
Nontuberculous mycobacterial infection after fractionated CO2 laser resurfacing
Creators: name: Miller, Becky A.
name: Stout, Jason E.
name: White, Becky
name: Lachiewicz, Anne M.
name: Miller, Melissa B.
name: Cox, Gary M.
name: Culton, Donna A.
name: MacKuen, Courtney
name: Groben, Pamela
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2013

description: Nontuberculous mycobacteria are increasingly associated with cutaneous infections after cosmetic procedures. Fractionated CO2 resurfacing, a widely used technique for photorejuvenation, has been associated with a more favorable side effect profile than alternative procedures. We describe 2 cases of nontuberculous mycobacterial infection after treatment with a fractionated CO2 laser at a private clinic. Densely distributed erythematous papules and pustules developed within the treated area within 2 weeks of the laser procedure. Diagnosis was confirmed by histologic analysis and culture. Both infections responded to a 4-month course of a multidrug regimen. An environmental investigation of the clinic was performed, but no source of infection was found. The case isolates differed from each other and from isolates obtained from the clinic, suggesting that the infection was acquired by postprocedure exposure. Papules and pustules after fractionated CO2 resurfacing should raise the suspicion of nontuberculous mycobacterial infection.
Additional file 1 of Fetuin-A alleviates neuroinflammation against traumatic brain injury-induced microglial necroptosis by regulating Nrf-2/HO-1 pathway
Creators: name: Zhao, Pengzhan
name: Wei, Yutian
name: Sun, Guangchi
name: Xu, Lei
name: Wang, Tian
name: Tian, Yufei
name: Chao, Honglu
name: Tu, Yiming
name: Ji, Jing
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Additional file 1: Fig. S1. Experimental design. A. Experiment was designed to identify global differences in protein expression between CCI and sham mouse groups. B. Experiment was designed to determine the endogenous Fetuin-A at each time point. C. Experiment was designed to detect the content of Fetuin-A after tail-vein Injection. D. Experiment was designed to detect whether intravenous administration of Fetuin-A could cross the intact BBB. E. Experiment was designed to test whether intravenous administration of Fetuin-A has biological toxicity. F. Experiment was designed to determine the extent and duration of BBB damage after CCI. G. Experiment was designed to detect the role of Fetuin-A in CCI model and explore the underlying mechanism of Fetuin-A. H. Experiment was designed to detect interference efficiency of AD-shFetuin-A and examine if the injury is worse by blocking Fetuin-A after CCI. I. Experiment was designed to detect the efficiency of microglia depletion and whether the therapeutic effect of Fetuin-A was dependent on the presence of microglia following CCI in vivo.
Solving the Cooling Flow Problem through Mechanical AGN Feedback
Creators: name: Gaspari, M.
name: Brighenti, F.
name: Ruszkowski, M.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Unopposed radiative cooling of plasma would lead to the cooling catastrophe, a massive inflow of condensing gas, manifest in the core of galaxies, groups and clusters. The last generation X-ray telescopes, Chandra and XMM, have radically changed our view on baryons, indicating AGN heating as the balancing counterpart of cooling. This work reviews our extensive investigation on self-regulated heating. We argue that the mechanical feedback, based on massive subrelativistic outflows, is the key to solving the cooling flow problem, i.e. dramatically quenching the cooling rates for several Gyr without destroying the cool-core structure. Using a modified version of the 3D hydrocode FLASH, we show that bipolar AGN outflows can further reproduce fundamental observed features, such as buoyant bubbles, weak shocks, metals dredge- up, and turbulence. The latter is an essential ingredient to drive nonlinear thermal instabilities, which cause the formation of extended cold gas, a residual of the quenched cooling flow and, later, fuel for the feedback engine. Compared to clusters, groups and galaxies require a gentler mechanical feedback, in order to avoid catastrophic overheating. We highlight the essential characteristics for a realistic AGN feedback, with emphasis on observational consistency.
description: Accepted by AN; 4 pages, 2 figures
Additional file 1 of The impact of nucleic acid testing to detect human immunodeficiency virus, hepatitis C virus, and hepatitis B virus yields from a single blood center in China with 10-years review
Creators: name: Wu, Danxiao
name: Feng, Fangjun
name: Wang, Xiaojuan
name: Wang, Dairong
name: Hu, Yiqin
name: Yu, Yang
name: Huang, Jihong
name: Wang, Min
name: Dong, Jie
name: Wu, Yaling
name: Zhu, Hong
name: Zhu, Faming
Publisher: name: figshare
Year: 2022
Subjects: subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Additional file 1: Table S1. ELISA reagents used for screening donors in HBsAg, anti-HCV, anti-HIV1/2 and anti-TP. Table S2. Non-discriminating reactive NAT yields in the seven blood services. Table S3. HBV NAT yields rates in the seven blood services. Table S4. HBV NAT yields for tested donations with HBsAg negative in the different demographic groups. Table S5. The follow-up results of 2 HCV NAT yields blood donors. Table S6. The follow-up results of 3 HIV NAT+ELISA- blood donors.
Visualising Virtual Communities: From Erdős to the Arts
Creators: name: Bowen, Jonathan P.
name: Wilson, Robin J.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Computers and Society (cs.CY)
subject: Digital Libraries (cs.DL)
subject: FOS: Computer and information sciences
subject: E.1; H.3.3; J.5; K.4.0
subject: 00A66 (Primary) 68P20 (Secondary)

description: Monitoring communities has become increasingly easy on the web as the number of visualisation tools and amount of data available about communities increase. It is possible to visualise connections on social and professional networks such as Facebook in the form of mathematical graphs. It is also possible to visualise connections between authors of papers. In particular, Microsoft Academic Search now has a large corpus of information on publications, together with author and citation information, that can be visualised in a number of ways. In mathematical circles, the concept of the "Erdős number" has been introduced, in honour of the Hungarian mathematician Paul Erdős, measuring the "collaborative distance" of a person away from Erdős through links by co-author. Similar metrics have been proposed in other fields, including acting. The possibility of exploring and visualising such links in arts fields is proposed in this paper.
description: 7 pages, 7 figures
Additional file 2 of Fetuin-A alleviates neuroinflammation against traumatic brain injury-induced microglial necroptosis by regulating Nrf-2/HO-1 pathway
Creators: name: Zhao, Pengzhan
name: Wei, Yutian
name: Sun, Guangchi
name: Xu, Lei
name: Wang, Tian
name: Tian, Yufei
name: Chao, Honglu
name: Tu, Yiming
name: Ji, Jing
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Additional file 2: Fig. S2. A, B. Western blot analysis of ZO-1 and Occludin expression from peri-contusional area. GAPDH was used as the loading control. And bar graphs show the results of analysis (by band density analysis) of these proteins (n = 3). C. The co-localization of ZO-1 or Occludin with CD31 by immunofluorescence assay with representative imaging. Scale bar = 10 μm (n = 3). Data are presented as the means ± SD; *P < 0.05 vs. sham, and n.s.: no significant difference.
Cytokine release syndrome in a patient with colorectal cancer after vaccination with BNT162b2.
Creators: name: Au, Lewis
name: Fendler, Annika
name: Shepherd, Scott TC
name: Rzeniewicz, Karolina
name: Cerrone, Maddalena
name: Byrne, Fiona
name: Carlyle, Eleanor
name: Edmonds, Kim
name: Del Rosario, Lyra
name: Shon, John
name: Haynes, Winston A
name: Ward, Barry
name: Shum, Ben
name: Gordon, William
name: Gerard, Camille L
name: Xie, Wenyi
name: Joharatnam-Hogan, Nalinie
name: Young, Kate
name: Pickering, Lisa
name: Furness, Andrew JS
name: Larkin, James
name: Harvey, Ruth
name: Kassiotis, George
name: Gandhi, Sonia
name: Consortium, Crick COVID-19
name: Swanton, Charles
name: Fribbens, Charlotte
name: Wilkinson, Katalin A
name: Wilkinson, Robert J
name: Lau, David K
name: Banerjee, Susana
name: Starling, Naureen
name: Chau, Ian
name: Consortium, CAPTURE
name: Turajlic, Samra
Publisher: name: The Francis Crick Institute
Year: 2021
Subjects: subject: Neurosciences
subject: FOS: Clinical medicine
subject: Model organisms
subject: Tumour Biology
subject: Signalling & Oncogenes
subject: Genetics & Genomics
subject: Genome Integrity & Repair
subject: Human Biology & Physiology
subject: Cell Biology
subject: Stem Cells
subject: Chemical Biology & High Throughput
subject: Infectious Disease
subject: Ecology,Evolution & Ethology
subject: Immunology
subject: Computational & Systems Biology

description: Patients with cancer are currently prioritized in coronavirus disease 2019 (COVID-19) vaccination programs globally, which includes administration of mRNA vaccines. Cytokine release syndrome (CRS) has not been reported with mRNA vaccines and is an extremely rare immune-related adverse event of immune checkpoint inhibitors. We present a case of CRS that occurred 5 d after vaccination with BTN162b2 (tozinameran)-the Pfizer-BioNTech mRNA COVID-19 vaccine-in a patient with colorectal cancer on long-standing anti-PD-1 monotherapy. The CRS was evidenced by raised inflammatory markers, thrombocytopenia, elevated cytokine levels (IFN-γ/IL-2R/IL-18/IL-16/IL-10) and steroid responsiveness. The close temporal association of vaccination and diagnosis of CRS in this case suggests that CRS was a vaccine-related adverse event; with anti-PD1 blockade as a potential contributor. Overall, further prospective pharmacovigillence data are needed in patients with cancer, but the benefit-risk profile remains strongly in favor of COVID-19 vaccination in this population.
Additional file 3 of Fetuin-A alleviates neuroinflammation against traumatic brain injury-induced microglial necroptosis by regulating Nrf-2/HO-1 pathway
Creators: name: Zhao, Pengzhan
name: Wei, Yutian
name: Sun, Guangchi
name: Xu, Lei
name: Wang, Tian
name: Tian, Yufei
name: Chao, Honglu
name: Tu, Yiming
name: Ji, Jing
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Additional file 3: Fig. S3. A-B. Western blot analysis of Fetuin-A expression. GAPDH was used as the loading control. And bar graphs show the results of analysis (by band density analysis) of these proteins (n = 3). C. H&E staining of hemispheres sections (n = 3). D. water content% (n = 3) were analyzed by statistical. E–F. cell death measured by TUNEL staining. Scale bar is 100 μm (n = 3). Data are presented as the means ± SD; n.s.: no significant difference.
Mexico: Afectaciones al Lago de Cuitzeo, Michoacán / Afectaciones al espacio escultórico de la UNAM por la construcción del edificio H de la Facultad de Ciencias Políticas / El Hospicio Cabañas en Guadalajara y su entorno inmediato amenazado por la construcción de una torre de oficinas (CDD) / Varias afectaciones al patrimonio de la Ciudad de Guanajuato, Gto. / Varias afectaciones al patrimonio de la Zona Monumental de Puebla
Creators: name: Hrsg., ICOMOS
Publisher: name: Heritage at Risk
Year: 2018

description: Heritage at Risk, H@R 2014-2015
title: Timing and Nature of Post-Collapse Sedimentation in Kulshan Caldera, North Cascades, Washington
Creators: name: Feeney, Dennis M.
Publisher: name: Western Washington University
Year: 2008

description:
Sedimentary rocks found in the 4.5 x 8 km Kulshan caldera of the Mount Baker volcanic field in the North Cascades, WA, indicate that the post-collapse basin hosted a lacustrine environment shortly after the initial collapse at 1.149 Ma (Hildreth, 1996). The sedimentary rocks of the 14 Goat area in Kulshan caldera are well-preserved in 124 meters of stratigraphic exposure. Blocks of wall rock debris in the lower stratigraphy show instability in the caldera wall. Intermediate and late stages are mainly turbidites composed primarily of sediments derived from extra-caldera ignimbrite. From these 1 interpret the 14 Goat area of Kulshan to have been a steep and deep depositional basin for most of its history. Additional sedimentary structures found in Kulshan caldera reveal a complex environmental history. Trough cross-bedding within a well sorted sandstone indicates channelized flow. Clastic dikes resulted from the overburdening of wet sediments. Dropstones found throughout the stratigraphy indicate an active ice field. Outside the stratigraphic section but within the 14 Goat area oscillation ripples indicate shallow water and raindrop imprints show drying. Paleomagnetic analysis of 12 sites spanning the entire stratigraphic column failed to show that any magnetic transition was recorded in the Kulshan sediments. Anisotropy of magnetic susceptibility results confirm that grain settling from quiet water produced the most prominent magnetic fabric and confirm secondary alteration was likely the cause of scatter in the remanent magnetization signal. A conservative estimate for the duration of the lacustrine environment at Kulshan caldera is 157 ka leading to a minimum rate of sedimentation of 79 cm/ka. A shorter estimate suggests duration of 22 ka and rate of sedimentation of 560 cm/ka. The sedimentary environments of Kulshan caldera are similar to other calderas with post-collapse depositional records. Kulshan caldera compares favorably to depositional models for small calderas (less than 10 km).
Ausgewählte Neufunde aus den Jahren 1978/79
Creators: name: Nitzschke, Waldemar
name: Stahlhofen, Heribert
Publisher: name: Jahresschrift für mitteldeutsche Vorgeschichte
Year: 2018

description: -
description: Jahresschrift für mitteldeutsche Vorgeschichte, Bd. 65 (1982): Jahresschrift für Mitteldeutsche Vorgeschichte
Additional file 4 of Fetuin-A alleviates neuroinflammation against traumatic brain injury-induced microglial necroptosis by regulating Nrf-2/HO-1 pathway
Creators: name: Zhao, Pengzhan
name: Wei, Yutian
name: Sun, Guangchi
name: Xu, Lei
name: Wang, Tian
name: Tian, Yufei
name: Chao, Honglu
name: Tu, Yiming
name: Ji, Jing
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Additional file 4: Fig. S4. A, B. Western blot analysis of Fetuin-A expression after transfected with shFetuin-A. GAPDH was used as the loading control. And bar graphs show the results of analysis (by band density analysis) of these proteins (n = 3). C. H&E staining of hemispheres sections (n = 3). D, E. Lesion volume (n = 5) and water content% (n = 5) were analyzed by statistical. F, G. Neuron death measured by TUNEL staining. Scale bar is 50 μm (n = 5). Data are presented as the means ± SD; *P < 0.05 vs. sham group, **P < 0.01 vs. sham group, #P < 0.05 vs. CCI + shCtrl group, and n.s.: no significant difference.
Additional file 1 of Relationship between changes in the public health nurses’ workforce and the empirical Bayes estimates of standardized mortality ratio: a longitudinal ecological study of municipalities in Japan
Creators: name: Kodama, Shimpei
name: Uwatoko, Futoshi
name: Koriyama, Chihaya
Publisher: name: figshare
Year: 2023
Subjects: subject: Statistics
subject: FOS: Mathematics

description: Additional file 1. Details on the Besag-York-Mollie (BYM) model and full Bayesian inference methods in this study. The Besag-York-Mollie (BYM) model and the full Bayesian inference method in this study are described in detail, including the model formulation, sampler algorithm, parameter prior distribution, and convergence criteria.
title: Timing and Conditions of Deformation and Metamorphism of the Structural Packages East of Harrison Lake, B.C.
Creators: name: Bennett, Jeffrey D.
Publisher: name: Western Washington University
Year: 1989

description:
Metamorphosed oceanic and arc-related lithologies of the Slollicum, Cogburn and Settler packages crop out to the east of Harrison Lake, B.C., within the southern Coast Plutonic Complex and represent the northern extension of the Cascade orogenic belt. The Cretaceous Spuzzum plutons intruded the packages in late syn- to post-metamorphic time, and several early Tertiary stocks intruded all units after deformation.

The Slollicum package is dominated by graphitic to politic phyllite, and felsic to mafic arc volcanics intercalated with marble, conglomerate and quartzite. The sediments dominate western exposures, and eastern exposures are mainly volcanics. U-Pb analysis of zircon in a volcanic interbed gives a concordant 146 Ma depositional age for the Slollicum package. The Cogburn package is composed of structurally juxtaposed blocks of graphitic phyllite, mafic metavolcanics, banded chert and marble. Serpentinite is common. The Settler package is dominated by politic schist interlayered with quartzite, amphibolite and conglomerate.

Foliations generally strike northwest, dip northeast and are accompanied by down-dip stretching lineations. Kinematic indicators show orogen-normal reverse-slip. Cleavage in the Slollicum package exhibits a strong influence of pressure solution. Cogburn and Settler packages each show two foliations, one preserved in poikiloblastic minerals and a dominant crenulation cleavage. The Harrison Lake shear zone is a late stage, right-lateral strike-slip shear zone that locally prints across the earlier fabrics after Spuzzum plutonism and prior to the intrusion of the early Tertiary stocks.

Metamorphic grade increases eastward from the chlorite and biotite zones of the greenschist facies in the Slollicum package to the garnet zone of the greenschist facies and the oligoclase/hornblende zone of the amphibolite facies in the Cogburn package through the staurolite zone to the sillimanite zone of the amphibolite facies in the Settler package.

Geothermobarometry indicates pressures of 3 to 4.5 kb in the biotite zone and 5.5 kb in the sillimanite zone. Temperatures in the sillimanite zone range up to approximately 750 ° C. A poly-metamorphic history is indicated by pseudomorphs of kyanite after andalusite in the Settler package.

Lineation-parallel slip on foliation planes, evidenced by augenshaped and boudinaged metamorphic minerals Indicates syn- to postmetamorphic deformation. Fabric relations indicate that this deformation primarily occurred prior to the intrusion of the Spuzzum plutons.

Early low-pressure metamorphism is interpreted to have been followed by higher grade, amphibolite facies metamorphism prior to and during deformation followed by the intrusion of the Spuzzum plutons coeval with peak metamorphism.
Winfried Henke und Hartmut Rothe, Paläoanthropologie
Creators: name: Czarnetzki, Alfred
Publisher: name: Bonner Jahrbücher
Year: 2018

description: Rezension zu: Winfried Henke und Hartmut Rothe, Paläoanthropologie. Springer-Verlag, Berlin 1994. 699 Seiten, 307 Abbildungen.
description: Bonner Jahrbücher, Bd. 195.1995(1996): Bonner Jahrbücher
Yann Le Bohec (Hrsg.), Militaires romains en Gaule civile
Creators: name: Klee, Margot
Publisher: name: Bonner Jahrbücher
Year: 2018

description: Rezension zu: Yann Le Bohec (Hrsg.), Militaires romains en Gaule civile. Actes de la Table-Ronde de mai 1991 organisee au Centre d'Études Romaines et Gallo-Romaines de l’Université Lyon III. Collection du Centre d’Études Romaines et Gallo-Romaines, Nouvelle Série, Band 11. Éditions De Boccard, Paris 1993. 77 Seiten, 15 Abbildungen, 7 Tafeln.
description: Bonner Jahrbücher, Bd. 195.1995(1996): Bonner Jahrbücher
Beat Meyer-Flügel, Das Bild der ostgotisch-römischen Gesellschaft bei Cassiodor
Creators: name: Wirth, Gerhard
Publisher: name: Bonner Jahrbücher
Year: 2018

description: Beat Meyer-Flügel, Das Bild der ostgotisch-römischen Gesellschaft bei Cassiodor. Leben und Ethik von Römern und Germanen in Italien nach dem Ende des weströmischen Reiches. Europäische
Hochschulschriften III, Band 533. Verlag Peter Lang, Frankfurt am Main u. a. 1992, 772 Seiten.
description: Bonner Jahrbücher, Bd. 195.1995(1996): Bonner Jahrbücher
Molecular dynamics simulation revealed the intrinsic conformational change of cellular inhibitor of apoptosis protein-1
Creators: name: Xu, Heng
name: Tang, Zhengkuan
name: Zuo, Yu
name: Xiong, Fengmin
name: Chen, Kaixian
name: Jiang, Hualiang
name: Luo, Cheng
name: Zhang, Hao
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Developmental Biology
subject: Cancer
subject: Hematology

description: Inhibitor of apoptosis proteins (IAPs) are important regulators of apoptosis, and protein targets for the development of anti-cancer drugs. Cellular inhibitor of apoptosis protein-1 (cIAP1) is an important member of IAPs. Peptides or small-molecular antagonists can induce the dimerization, auto-ubiquitination, and proteasomal degradation of the cellular inhibitor of apoptosis protein-1 (cIAP1). While in the absence of antagonists, several mutations of the cIAP1 protein also lead to its dimerization and auto-ubiquitination. Even though the crystal structure of cIAP1 protein has been determined, the intrinsic mechanism of its dimerization remains unexplored. Accumulating evidence indicated that intrinsic conformational change existed during the binding of antagonists with cIAP1 protein, or introduction of mutations. To reveal this intrinsic conformational change, molecular dynamics simulations at microsecond scale were applied for the wild-type and mutant-type cIAP1 proteins. Compared to the crystal structure, significant conformational change was observed during the simulations, which could explain the importance of previously identified key mutations. To validate these findings revealed by our simulations, a new mutation D303A was constructed and the following native polyacrylamide gel electrophoresis (native-PAGE) assay observed a proportion of spontaneous dimerization, in comparison with the wild-type control. Taken together, these computational and experimental results revealed the intrinsic conformational change of cIAP1, which could not only explain previously identified key mutations, but also be exploited for further design and development of anti-tumor compounds that target the cIAP1 protein. Communicated by Ramaswamy H. Sarma
Meso-scale turbulence in living fluids
Creators: name: Wensink, Henricus H.
name: Dunkel, Jörn
name: Heidenreich, Sebastian
name: Drescher, Knut
name: Goldstein, Raymond E.
name: Löwen, Hartmut
name: Yeomans, Julia M.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: Turbulence is ubiquitous, from oceanic currents to small-scale biological and quantum systems. Self-sustained turbulent motion in microbial suspensions presents an intriguing example of collective dynamical behavior amongst the simplest forms of life, and is important for fluid mixing and molecular transport on the microscale. The mathematical characterization of turbulence phenomena in active non-equilibrium fluids proves even more difficult than for conventional liquids or gases. It is not known which features of turbulent phases in living matter are universal or system-specific, or which generalizations of the Navier-Stokes equations are able to describe them adequately. Here, we combine experiments, particle simulations, and continuum theory to identify the statistical properties of self-sustained meso-scale turbulence in active systems. To study how dimensionality and boundary conditions affect collective bacterial dynamics, we measured energy spectra and structure functions in dense Bacillus subtilis suspensions in quasi-2D and 3D geometries. Our experimental results for the bacterial flow statistics agree well with predictions from a minimal model for self-propelled rods, suggesting that at high concentrations the collective motion of the bacteria is dominated by short-range interactions. To provide a basis for future theoretical studies, we propose a minimal continuum model for incompressible bacterial flow. A detailed numerical analysis of the 2D case shows that this theory can reproduce many of the experimentally observed features of self-sustained active turbulence.
description: accepted PNAS version, 6 pages, click doi for Supplementary Information
The Frequency of Debris Disks at White Dwarfs
Creators: name: Barber, Sara D.
name: Patterson, Adam J.
name: Kilic, Mukremin
name: Leggett, S. K.
name: Dufour, P.
name: Bloom, J. S.
name: Starr, D. L.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We present near- and mid-infrared photometry and spectroscopy from PAIRITEL, IRTF, and Spitzer of a metallicity-unbiased sample of 117 cool, hydrogen-atmosphere white dwarfs from the Palomar-Green survey and find five with excess radiation in the infrared, translating to a 4.3+2.7-1.2% frequency of debris disks. This is slightly higher than, but consistent with the results of previous surveys. Using an initial-final mass relation, we apply this result to the progenitor stars of our sample and conclude that 1-7Msol stars have at least a 4.3% chance of hosting planets; an indirect probe of the intermediate-mass regime eluding conventional exoplanetary detection methods. Alternatively, we interpret this result as a limit on accretion timescales as a fraction of white dwarf cooling ages; white dwarfs accrete debris from several generations of disks for ~10Myr. The average total mass accreted by these stars ranges from that of 200km asteroids to Ceres-sized objects, indicating that white dwarfs accrete moons and dwarf planets as well as Solar System asteroid analogues.
description: ApJ, in press
Additional file 5 of Zinc-mediated activation of CREB pathway in proliferation of pulmonary artery smooth muscle cells in pulmonary hypertension
Creators: name: Xiao, Genfa
name: Lian, Guili
name: Wang, Tingjun
name: Chen, Weixiao
name: Zhuang, Wei
name: Luo, Li
name: Wang, Huajun
name: Xie, Liangdi
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer

description: Additional file 4: Figure S4. Identification of protein kinases involved in hypoxia-prolonged CREB phosphorylation. a The effect of ERK1/2, CAMK and PKC on CREB phosphorylation in hypoxia-treated PASMCs. Serum-starved PASMCs were pretreated with ERK1/2 inhibitor PD98059 (20 μM), CaMK inhibitor KN62 (10 μM) and PKC inhibitor chelerythrine chloride (CHE, 10 µM) for 24 h in the present of hypoxia, respectively. Then cells then were stimulated by 10% fetal bovine serum (FBS) for 1 h in the present of hypoxia and protein kinase inhibitors. n=5, 6 and 5. b The effect of P38MAPK, PI3K and PKA on CREB phosphorylation in hypoxia-treated PASMCs. Serum-starved PASMCs were pretreated with P38MAPK inhibitor SB203580 (20 μM), PI3K inhibitor LY294002 (50 μM) and PKA inhibitor H89 (10 μM) for 24h in the present of hypoxia, respectively. Then cells were stimulated by 10% FBS for 1 h in the present of hypoxia and protein kinase inhibitors. n=5, 5 and 5. c The effect of staurosporine (Sto, 10 nM) on CREB phosphorylation in hypoxia-pretreated PASMCs. The PASMCs were starved with serum-free DMEM/F12 and exposed to hypoxia for 24h, then, the cells were simultaneously stimulated by 10% FBS and Sto for 1 h in the present of hypoxia. n=6. *p<0.05 vs. Ctr, #p<0.05 vs. Hypoxia+10% FBS group.
Schiek, Das Gräberfeld der Merowingerzeit bei Oberflacht (Gemeinde Seitingen-Oberflacht, Kr. Tuttlingen)
Creators: name: Päffgen, Bernd
Publisher: name: Bonner Jahrbücher
Year: 2018

description: Rezension zu: Siegwalt Schiek, Das Gräberfeld der Merowingerzeit bei Oberflacht (Gemeinde Seitingen-Oberflacht, Kr. Tuttlingen). Mit Beiträgen von P. Filzer, H.-J. Hundt, F. Zauner. Forschungen und Berichte zur Vor- und Frühgeschichte in Baden-Württemberg, Band 41,1. Konrad Theiss Verlag, Stuttgart 1992. 166 Seiten, 63 Abbildungen und 113 Tafeln.

Rezension zu: Peter Paulsen, Die Holzfunde aus dem Gräberfeld bei Oberflacht und ihre kulturhistorische Bedeutung. Forschungen und Berichte zur Vor- und Frühgeschichte in Baden-Württemberg, Band 41,2. Konrad Theiss Verlag, Stuttgart 1992. 162 Seiten und 135 Abbildungen.
description: Bonner Jahrbücher, Bd. 195.1995(1996): Bonner Jahrbücher
The rational-transcendental dichotomy of Mahler functions
Creators: name: Bell, Jason P.
name: Coons, Michael
name: Rowland, Eric
Publisher: name: arXiv
Year: 2012
Subjects: subject: Complex Variables (math.CV)
subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 30D05 (Primary) 11B37, 05A15 (Secondary)

description: In this paper, we give a new proof of a result due to Bezivin that a D-finite Mahler function is necessarily rational. This also gives a new proof of the rational-transcendental dichotomy of Mahler functions due to Nishioka. Using our method of proof, we also provide a new proof of a Polya-Carlson type result for Mahler functions due to Rande; that is, a Mahler function which is meromorphic in the unit disk is either rational or has the unit circle as a natural boundary.
description: 10 pages, 1 figure; added reference to Bezivin's paper
Additional file 5 of Fetuin-A alleviates neuroinflammation against traumatic brain injury-induced microglial necroptosis by regulating Nrf-2/HO-1 pathway
Creators: name: Zhao, Pengzhan
name: Wei, Yutian
name: Sun, Guangchi
name: Xu, Lei
name: Wang, Tian
name: Tian, Yufei
name: Chao, Honglu
name: Tu, Yiming
name: Ji, Jing
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Additional file 5: Fig. S5. A–D. Western blot analysis of Nrf-2 or HO-1 expression after transfected with ML385 or siHO-1, GAPDH were used as the loading control. And bar graphs show the results of analysis (by band density analysis) of these proteins (n = 3). Data are presented as the means ± SD; *P < 0.05 vs. control, #P < 0.05 vs. Glu + siCtrl group, and n.s.: no significant difference
Quantification of local geometry and local symmetry in models of disordered materials
Creators: name: Cliffe, Matthew J.
name: Goodwin, Andrew L.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We suggest two metrics for assessing the quality of atomistic configurations of disordered materials, both of which are based on quantifying the orientational distribution of neighbours around each atom in the configuration. The first metric is that of geometric invariance: i.e., the extent to which the neighbour arrangements are as similar as possible for different atoms, allowing for variations in frame of reference. The second metric concerns the degree of local symmetry. We propose that for a set of configurations with equivalent pair correlations, ranking highly those configurations with low geometric invariance but with high local symmetry selects for structural simplicity in a way that does not rely on formal group theoretical language (and hence long-range periodic order). We show that these metrics rank a range of SiO2 and a-Si configurations in an intuitive manner, and are also significantly more sensitive to unphysical features of those configurations in a way that metrics based on pair correlations are not. We also report that implementation of the metrics within a reverse Monte Carlo algorithm gives rise to an energy landscape that is too coarse (at least in this initial implementation) for amorphous structure "solution".
description: 8 pages, 8 figures, formatted as for Physica Status Solidi B
Additional file 6 of Fetuin-A alleviates neuroinflammation against traumatic brain injury-induced microglial necroptosis by regulating Nrf-2/HO-1 pathway
Creators: name: Zhao, Pengzhan
name: Wei, Yutian
name: Sun, Guangchi
name: Xu, Lei
name: Wang, Tian
name: Tian, Yufei
name: Chao, Honglu
name: Tu, Yiming
name: Ji, Jing
Publisher: name: figshare
Year: 2022
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Additional file 6: Fig. S6. PLX5622, which was specific CSF1R inhibitor, was able to achieve robust brain-wide microglia elimination. We fed PLX5622 to mice and tested its elimination efficiency. A, B. Immunofluorescence for Iba-1 in the hemisphere and statistical analysis of Iba-1. Scale bar is 100 μm (n = 3). Data are presented as the means ± SD; ***P < 0.001 vs. sham + Veh group, ###P < 0.001 vs. CCI + Veh group, and n.s.: no significant difference
Additional file 1 of Investigating the effect of multimedia education based on the health belief model in preventing COVID-19 in pregnant women
Creators: name: Shakerinejad, Ghodratollah
name: Navak, Tayebeh
name: Hatemzadeh, Nasser
name: Haghi, Mehdi
name: Haghigizadeh, Mohammad Hossein
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Additional file 1. The questionnire used in the study to collect the data.
Usability, Design and Content Issues of Mobile Apps for Cultural Heritage Promotion: The Malta Culture Guide Experience
Creators: name: Boiano, Stefania
name: Bowen, Jonathan P.
name: Gaia, Giuliano
Publisher: name: arXiv
Year: 2012
Subjects: subject: Human-Computer Interaction (cs.HC)
subject: Computers and Society (cs.CY)
subject: Multimedia (cs.MM)
subject: FOS: Computer and information sciences
subject: H.5.1; H.5.2; J.5; K.4.0
subject: 00A66 (Primary) 68N01 (Secondary)

description: The paper discusses the experience of producing and distributing an iPhone app for promotion of the Maltese Cultural Heritage on behalf of the Malta Tourism Authority. Thanks to its position at the heart of the Mediterranean Sea, Malta has been a crossroads of civilisations whose traces are still visible today, leaving a particularly rich and varied cultural heritage, from megalithic temples to baroque palaces and Caravaggio masterpieces. Conveying all these different aspects within a single application, using textual, visual, and audio means, has raised many different issues about the planning and production of cultural content for mobile usage, together with usability aspects regarding design and distribution of a mobile app. In this paper, we outline all of these aspects, focusing on the design and planning strategies for a long-term user commitment and how to evaluate results for cultural mobile applications. We include experience of all the steps of developing a mobile app, information that is of possible benefit to other app developers in the cultural sector.
description: 8 pages, 7 figures, EVA London 2012: Electronic Visualisation and the Arts, London, UK, 10-12 July 2012
title: Does a surgeon's visual parameters and other attributes have an effect on the safety and rate of complications in eye surgery?
Creators: name: Elahi, Faizan
Publisher: name: Oxford Brookes University
Year: 2020

description: Purpose: To investigate different factors which may play a role in the safety of eye surgery. Method: A survey questionnaire with 22 questions was sent to the members of the UK & Eire Glaucoma Society (UKEGS ) and Midlands Ophthalmic Society (MOS). Results: 73 responses were received within 2 weeks of the survey being sent. 77.78% were consultant ophthalmologists. 96% agreed with seniority being linked to safety of surgery and 89% felt higher volume of surgery performed may reduce complications. Although 89% were right-handed, 7% left-handed and 4% ambidextrous; all the consultants felt that ambidextrous surgeons are the safest. One clinician was colour-blind, but the majority felt that there was no significant evidence linking colour-blindness with poor surgical outcomes. Although almost everyone felt the importance of visual and stereo acuity for eye surgeons, the majority did not have a formal assessment for these for doing their job. 79% respondents felt the need for checking various visual parameters at varying intervals. Hunger, anger, stress & limited time, tiredness and alcohol were deemed to be the greatest risks to safe surgery. Conclusion: Visual parameters are regarded as important for the safety of eye surgeries. However, there is no requirement for formal assessment for these in the NHS; although most surgeons would be happy for these assessments at varying intervals.
An Effective Fingerprint Classification and Search Method
Creators: name: Bhuyan, Monowar H.
name: Bhattacharyya, D. K.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Computer Vision and Pattern Recognition (cs.CV)
subject: Cryptography and Security (cs.CR)
subject: FOS: Computer and information sciences
subject: I.5.3
subject: 68U35

description: This paper presents an effective fingerprint classification method designed based on a hierarchical agglomerative clustering technique. The performance of the technique was evaluated in terms of several real-life datasets and a significant improvement in reducing the misclassification error has been noticed. This paper also presents a query based faster fingerprint search method over the clustered fingerprint databases. The retrieval accuracy of the search method has been found effective in light of several real-life databases.
description: 10 pages, 8 figures, 6 tables, referred journal publication
Additional file 2 of Investigating the effect of multimedia education based on the health belief model in preventing COVID-19 in pregnant women
Creators: name: Shakerinejad, Ghodratollah
name: Navak, Tayebeh
name: Hatemzadeh, Nasser
name: Haghi, Mehdi
name: Haghigizadeh, Mohammad Hossein
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Additional file 2. Flow chart.
G-matrix stability of clinally diverging populations of an annual weed
Creators: name: Henry, Georgia A.
name: Stinchcombe, John R.
Publisher: name: Zenodo
Year: 2022
Subjects: G-matrix
clinal divergence
Ipomoea hederacea
constraint
Multivariate evolution

description: How phenotypic and genetic divergence among populations is influenced by the genetic architecture of those traits, and how microevolutionary changes in turn affect the within-population patterns of genetic variation, are of major interest to evolutionary biology. Work on Ipomoea hederacea, an annual vine, has found genetic clines in the means of a suite of ecologically important traits, including flowering time, growth rate, seed mass, and corolla width. Here we investigate the genetic (co)variances of these clinally varying traits in two northern range-edge and two central populations of Ipomoea hederacea to evaluate the influence of the genetic architecture on divergence across the range. We find 1) limited evidence for clear differentiation between Northern and Southern populations in the structure of G, suggesting overall stability of G across the range despite mean trait divergence and 2) that the axes of greatest variation (gmax) were unaligned with the axis of greatest multivariate divergence. Together these results indicate the role of the quantitative genetic architecture in constraining evolutionary response and divergence among populations across the geographic range.
description: All analyses were performed in R.Funding provided by: Natural Sciences and Engineering Research Council of Canada
Crossref Funder Registry ID: http://dx.doi.org/10.13039/501100000038
Award Number:
description: Data was collected on plants in a glasshouse as described in the methods section of the associated paper. Entries with NAs were removed. Data were standardized as described in the paper, and saved as new columns with the ".s" suffix.
title: A New Determination of Pacific-Kula Relative Motions
Creators: name: Cashman, Harold J.
Publisher: name: Western Washington University
Year: 1990

description:
A new method is presented and used to determine estimates of instantaneous relative motion vectors for the Pacific plate relative to the Farallon and Kula plates between magnetic chrons 34 and 24 (84 to 56 Ma). A weighted chi-square minimization technique was employed that has as input sequential magnetic anomaly picks taken from original ship-track profiles, and fracture-zone azimuths estimated from bathymetric control and offsets in magnetic lineations. Assignment of errors to the input data allows the use of critical chi-square limits to obtain confidence intervals on pole locations and their angular rates. Eleven distinctive magnetic anomalies chosen as control points within the 28 million year time span result in ten possible instantaneous relative motion poles. Within the uncertainties, 3 distinct pole positions have been modeled for Pacific-Kula spreading spanning the time between chrons 34 to 33 (84 to 77 Ma), 33 to 25 (77 to 59 Ma), and 25 to 24 (59 to 56 Ma). Six significant rate changes are seen within the interval between chrons 33 and 25. These results are consistent with but more detailed than earlier hypotheses, which suggested that Pacific-Kula relative motions can be described by a single pole location between chron 32 and 25, accompanied by three changes in angular rates. Previous workers have determined that Pacific-Farallon relative motion can be described by two pole locations; this study used these pole positions to update Pacific-Farallon angular rates for the ten time intervals.

Updated relative motions were used in combination with the trace of the Pacific- Farallon-Kula (PFK) triple junction to investigate the possibility of asymmetric spreading. Except for two time intervals, the updated relative motions agree well with the observed migration of the PFK triple junction (as seen at the apexes of the Great Magnetic Bight) which implies, at least on average, consistency with the assumption of symmetric spreading.

Results of this study differ from those of previous studies in the greater number of relative motion changes found, presumably in response to changes along Kula and Farallon subduction zones. These updated models should provide increased insight into the cause of changing tectonic environments along western North America during the late Cretaceous and early Tertiary.
Bloch-Kato pro-p groups and locally powerful groups
Creators: name: Quadrelli, Claudio
Publisher: name: arXiv
Year: 2012
Subjects: subject: Group Theory (math.GR)
subject: K-Theory and Homology (math.KT)
subject: Number Theory (math.NT)
subject: FOS: Mathematics
subject: 20E18, 12G05

description: A Bloch-Kato pro-p group G is a pro-p group with the property that the F_p-cohomology ring of every closed subgroup of G is quadratic. It is shown that either such a pro-p group G contains no closed free pro-p groups of infinite rank, or there exists an orientation $θ\colon G\rightarrow \Z_p^\times$ such that G is theta-abelian. In case that G is also finitely generated, this implies that G is powerful, p-adic analytic with d(G)=cd(G), and its \F_p-cohomology ring is an exterior algebra. These results will be obtained by studying locally powerful groups (see Theorem A). There are certain Galois-theoretical implications, since Bloch-Kato pro-p groups arise naturally as maximal pro-p quotients and pro-p Sylow subgroups of absolute Galois groups (see Corollary 4.9). Finally, we study certain closure operations of the class of Bloch-Kato pro-p groups, connected with the Elementary type conjecture.
description: 17 pages, to appear on Forum Math
title: Turismo médico em Portugal : análise de viabilidade do desenvolvimento de um operador turístico
Creators: name: Pereira, Joana Brilha
name: Antão, Mário
Publisher: name: Universidade Lusíada Editora
Year: 2016

description: Lusíada. Economia & Empresa. - ISSN 1645-6750. - S. 2, n. 20 (2016). - p. 61-79