cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Hydrophilicity effect on CO2/CH4 separation using carbon nanotube membranes: insights from molecular simulation
Creators: name: Cao, Wei
name: Lu, Linghong
name: Zhou, Musen
name: Tow, Garrett M.
name: Huang, Liangliang
name: Yang, Tingting
name: Lu, Xiaohua
Publisher: name: Taylor & Francis
Year: 2017
Subjects: Biochemistry
Space Science
Medicine
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Virology

description: Molecular simulation methods were applied to study the effect of hydrophilicity on CO2/CH4 separation using carbon nanotube (CNT) membranes. CNTs with a diameter of ~1 nm were functionalised by varying amounts of carbonyl groups, in order to achieve various hydrophilicity. The presence of –CO groups inside the CNT allow a significant gain in the diffusion selectivity of CO2, while in contrast the adsorption selectivity is hardly changed. The corresponding permeation selectivity increases as the hydrophilicity of the CNT-based membrane increases. However, the permeability of CO2 decreases due to a combination of the intermolecular interactions between the gas and functional groups and the steric effects of the added functional groups. Considering both the permeation selectivity and permeability, it was found that the maximum separation performance is achieved in a certain hydrophilic CNT membrane. Moreover, the separation performance of hydrophilic CNTs for CO2/CH4 mixtures breaks the Robeson upper bound.
Two new Anti-TMV active chalconoid analogues from the root of Phyllanthus emblica
Creators: name: Yan, He
name: Han, Li Rong
name: Zhang, Xing
name: Feng, Jun Tao
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology

description: Two new chalconoid analogues, emblirol A (1) and B (2), along with three known ones (3–5), were isolated from the root of the Phyllanthus emblica L. Their structures were elucidated on the basis of spectral data. Compound 1 and 2 showed moderate anti-TMV activity with inhibition rates 79.6 and 62.1% at a concentration of 1 mg/mL, respectively.
Процессуальный порядок исключения показаний обвиняемого, полученных с нарушением требований УПК РФ, в ходе судебного производства по уголовному делу
Creators: name: Георгий Юрьевич ЮРЬЕВ
Publisher: name: Закон и право
Year: 2020
Subjects: допустимость доказательств
показания обвиняемого
исключение показаний обвиняемого
судебное производство
суд

description: В статье рассматриваются проблемы процессуального порядка исключения показаний обвиняемого, полученных с нарушением требований УПК РФ, в ходе судебного производства по уголовному делу.
Rapid identification and simultaneous analysis of multiple constituents from Rheum tanguticum Maxim. ex Balf. by UPLC/Q-TOF-MS
Creators: name: Gao, Liang-Liang
name: Guo, Tao
name: Xu, Xu-Dong
name: Yang, Jun-Shan
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified

description: Rhubarb contains biologically active compounds such as anthraquinones, anthrones, stilbenes and tannins. A rapid and efficient UPLC/Q-TOF-MS/MS method was developed and applied towards identifying the constituents of Rheum tanguticum Maxim. ex Balf. for the first time. Chemical constituents were separated and investigated by UPLC/Q-TOF-MS/MS in the negative ion mode. The ESI-MS2 fragmentation pathways of four types of compounds were interpreted, providing a very useful guidance for the characterisation of different types of compounds. Based on the exact mass information, fragmentation characteristic and LC retention time of 7 reference standards, 30 constituents were tentatively identified from the methanol extract of R. tanguticum. Among them, seven compounds were described for the first time from R. tanguticum and two from the genus Rheum were described for the first time. The analytical tool used here is valuable for the rapid separation and identification of multiple and minor constituents in methanol extracts of R. tanguticum.
One-Pot Efficient Pseudo Five Components Synthesis of 4,4′-(Arylmethylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ols) at Room Temperature Assisted by K2CO3
Creators: name: Dipanwita Banerjee
name: Karmakar, Rajiv
name: Kayal, Utpal
name: Gourhari Maiti
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: Plant Biology

description: A convenient approach for the synthesis of 4, 4′-(arylmethylene)-bis (3-methyl-1-phenyl-1H-pyrazol-5-ols) by an efficient one-pot reaction of aromatic/aliphatic aldehydes, phenylhydrazine and ethyl acetoacetate by using sub-stoichiometric amount of K2CO3 in acetonitrile solvent at room temperature is described. This protocol of one-pot synthesis produced a library of bis-pyrazolylmethane derivatives, a potential bioactive compound in very good to excellent yields.
Molecular mechanism of the selectivity between BAFF/APRIL and their receptors by molecular simulations
Creators: name: Fu, Xuegang
name: Mao, Zhuo
name: Li, Siming
name: Guan, Yunyun
name: Jian, Xiaodong
name: Sun, Jian
name: Wei, Jing
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) belonging to the tumour necrosis factor (TNF) ligand family can bind three unusual TNF receptors (BCMA, TACI and BR3) with various binding affinities. BAFF and APRIL are regarded as promising therapeutic targets for autoimmune diseases because of their pivotal roles in cell survival and immune regulation. In this work, we carried out molecular dynamics calculations to explore the structural and chemical features responsible for ligand recognition by extracellular functional segments of TNF receptors. We found that the conserved pocket Dcons of BAFF/APRIL contacted the DxL motif of TNF receptors, while the Dspe1–3 sub-domains were responsible for their different affinities, especially Dspe1 and Dspe2. The residues at position II–V of DxL motif were wrapped into the Dcons pocket via salt-bridge and hydrophobic interactions. The hydrophobic residues of strand3 and helix1 in TNF receptors provided remarkable contributions for the affinities to BAFF/APRIL. Additionally, ArgVI of DxL motif played a key role in the binding selectivity via salt-bridge interaction with residue D275B in BAFF. Arg27 in BCMA contributed to the high affinity for APRIL so that BCMA showed a preference for APRIL. Our studies indicated that Arg84 and Gln95 in TACI2 played an important role in the selectivity of two cysteine-rich domain segments in TACI, leading to the higher binding affinities of TACI2 than those of TACI1. The primary cause of the disability to bind APRIL was the space conflict with the rigid conformation of the C-terminus coil of BR3. These thorough understanding of the molecular mechanism for BAFF/APRIL recognition by their receptors provides new insights for guiding inhibitor design.
[Cu]-catalyzed direct coupling of dibromoalkenes: Synthesis of symmetrical 1,3-diynes and triazoles
Creators: name: Lodi Mahendar
name: Bokka Venkat Ramulu
name: Gedu Satyanarayana
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences

description: An efficient [Cu]-catalyzed homocoupling of 1,1-dibromoalk-1-enes is described for the synthesis of symmetrical 1,3-diyines. The method showed good substrate scope and amenable to aryl and heteroaryl systems. Significantly, the strategy was also successfully applied to the sequential one-pot synthesis of triazoles.
Проблемы самостоятельности следователя. История и современность
Creators: name: Ренат Шамильевич ГАДЖИЕВ
Publisher: name: Закон и право
Year: 2020
Subjects: следователь
прокурор
руководитель следственного органа
процессуальная самостоятельность
история предварительного расследования

description: В данной статье рассматриваются полномочия следователя с точки зрения судопроизводства, анализируется его самостоятельность как участника уголовного судопроизводства. Критически оценивается реформа российского уголовно-процессуального законодательства, в результате которой получила существенное ограничение процессуальная самостоятельность следователя.
Gastrointestinal stability of dihydromyricetin, myricetin, and myricitrin: an in vitro investigation
Creators: name: Xiang, Dong
name: Wang, Chen-guang
name: Wang, Wen-qing
name: Shi, Chun-yang
name: Xiong, Wei
name: Wang, Meng-die
name: Fang, Jian-guo
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Computational Biology

description: The gastrointestinal (GI) stability of three flavonoids, dihydromyricetin (DMY), myricetin (MYR), and myricitrin (MYT), was examined in simulated physiological fluids. Several factors that may influence the degradation rate of theses flavonoids were evaluated, including pH and the presence of pepsin and pancreatin enzymes. We found that GI stability followed the order of MYT > DMY > MYR. These flavonoids were stable in simulated gastric fluids and buffer solutions (pH 1.2), but encountered a pseudo-first-order kinetic degradation in simulated intestinal fluids and buffer solutions (pH 6.8). We conclude that it is the pH, rather than the presence of pepsin or pancreatin, which most strongly influences the stability of these three flavonoids. Further study of the stability of the compounds using a pH range (1.0–8.0) indicated potential instability in the duodenum, small intestine, and colon. Therefore, we conclude that the low bioavailability of these flavonoids may be due to their poor stability in the GI tract.
Solvent-free Synthesis of Polyhydroquinoline and 1,8-dioxodecahydroacridine Derivatives via the Hantzsch Reaction Catalyzed by a natural organic acid: A green method
Creators: name: Imène Sehout
name: Boulcina, Raouf
name: Boudjemaa Boumoud
name: Taous Boumoud
name: Abdelmadjid Debache
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: Solvent-free and high yielding one-pot synthesis of 1,8-dioxodecahydroacridine and polyhdroquinoline derivatives have been described via Hantzsch condensation of various aldehydes, ammonium acetate with cyclic 1,3-dicarbonyl compounds and ethyl acetoacetate in a very simple, efficient, and environmentally benign method using ascorbic acid as a nontoxic organocatalyst.
Avdat LTER site - Meteorology Data (2008-2010)
Creators: name: [Unknown]
Publisher: name: FZ-Juelich B2SHARE
Year: 2020

description: LTER site in the Negev Highland of Israel. Annual rainfall of 80-100 mm, high degree of geo-diversity, Vegetation spot pattern about 600 species of plants. Ten years of meteorology data (2008-2018)
EIN2-mediated signaling is involved in pre-invasion defense in Nicotiana benthamiana against potato late blight pathogen, Phytophthora infestans
Creators: name: Soriya Rin
name: Mizuno, Yuri
name: Shibata, Yusuke
name: Mayuka Fushimi
name: Katou, Shinpei
name: Sato, Ikuo
name: Chiba, Sotaro
name: Kawakita, Kazuhito
name: Daigo Takemoto
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: Science Policy
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Plant Biology

description: Nicotiana benthamiana ABCG1 and ABCG2 are ABC transporters which are probably involved in the export of capsidiol, the major phytoalexin of Nicotiana species. While capsidiol export by these transporters plays an essential role in post-invasion defense against Phytophthora infestans, they also export unidentified antimicrobial compound(s) involved in pre-invasion defense. In this study, promoter activity of NbABCG2 (Pabcg2a) was analyzed using a GFP marker. Expression of GFP under the control of Pabcg2a was significantly increased by co-expression with the INF1 elicitor from P. infestans. Disruption of the ethylene-responsive GCC box in Pabcg2a compromised INF1-induced activation of Pabcg2a. Consistently, penetration by P. infestans was increased by gene-silencing of NbEIN2, the key ethylene-signaling component, suggesting the involvement of ethylene for pre-invasion defense of N. benthamiana.
Is maternal smoking during pregnancy associated with an increased risk of congenital heart defects among offspring? A systematic review and meta-analysis of observational studies
Creators: name: Zhang, Dongyu
name: Cui, Hao
name: Zhang, Long
name: Huang, Yanjie
name: Zhu, Jun
name: Li, Xiaohong
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Science Policy

description: Objective: To investigate the association between maternal smoking during pregnancy and risk of congenital heart defects (CHDs) among offspring. Methods: PubMed, EMBASE, and Web of Science were searched for eligible studies. The outcomes of interest included risk of any CHD and nine subtypes. We summarized study characteristics and used a random-effects model in meta-analysis, and a two-stage dose–response model was utilized to assess the association between smoking consumption and risk. Statistical heterogeneity was assessed by a chi-squared test of the Cochrane Q statistic and I-squared value. Publication bias was assessed by funnel plots and Egger’s test, and trim and fill method was utilized when publication bias existed. Results: Forty-three observational epidemiologic studies were included. The pooled risk ratio (RR) of any CHD was 1.11 (95% CI: 1.04, 1.18), but it exhibited substantial statistical heterogeneity (p < 0.001, I2 = 69.0%). In sensitivity analysis, we observed significant associations for atrial septal defect (ASD) and marginally significant associations for septal defects (SPD). The two-stage dose–response analysis showed evidence to support that higher levels of tobacco smoke was associated with an increased risk of septal defects, particularly for ASD and VSD (ventricular septal defect). Conclusion: Our study presents evidence to support the cardiovascular teratogenic effect of maternal smoking during pregnancy, and their offspring may suffer from approximately a 10% relative increase in the risk of CHDs on average.
Общие проблемы совершенствования доказательственного права в России
Creators: name: Мурад Джавидович ДЖАЛАЛОВ
Publisher: name: Закон и право
Year: 2020
Subjects: доказательство
состязательность
законность
доказывание
судопроизводство
совершенствование

description: В статье обосновывается актуальность изучения существующих проблем в системе доказательств уголовного процесса. Проблемы доказывания по уголовным делам на протяжении уже не одного десятилетия являются наиболее обсуждаемыми в уголовно-процессуальной науке, что особенно характерно для периодов реформ в правоохранительной и судебной системах, в уголовнопроцессуальном законодательстве.
One-pot efficient pseudo-five-components synthesis of 4,4′-(arylmethylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ols) at room temperature assisted by K2CO3
Creators: name: Dipanwita Banerjee
name: Karmakar, Rajiv
name: Kayal, Utpal
name: Gourhari Maiti
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: Plant Biology

description: A convenient approach for the synthesis of 4,4′-(arylmethylene)-bis(3-methyl-1-phenyl-1H-pyrazol-5-ols) by an efficient one-pot reaction of aromatic aldehydes, phenylhydrazine, and ethyl acetoacetate by using substoichiometric amount of K2CO3 in acetonitrile solvent at room temperature is described. This protocol of one-pot synthesis produced a library of bis-pyrazolylmethane derivatives, a potential bioactive compound in very good to excellent yields.
Involvement of protoporphyrin IX accumulation in the pathogenesis of isoniazid/rifampicin-induced liver injury: the prevention of curcumin
Creators: name: He, Leiyan
name: Guo, Yaoxue
name: Deng, Ye
name: Li, Chun
name: Zuo, Chengzi
name: Peng, Wenxing
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Combination of isoniazid (INH) and rifampicin (RFP) causes liver injury frequently among tuberculosis patients. However, mechanisms of the hepatotoxicity are not entirely understood. Protoporphyrin IX (PPIX) accumulation, as an endogenous hepatotoxin, resulting from isoniazid and rifampicin co-therapy (INH/RFP) has been reported in PXR–humanized mice. Aminolevulinic acid synthase1 (ALAS1), ferrochelatase (FECH) and breast cancer resistance protein (BCRP) play crucial roles in PPIX synthesis, metabolism and transport, respectively. Herein, this study focused on the role of INH/RFP in these processes. We observed PPIX accumulation in human hepatocytes (L-02) and mouse livers. FECH expression was initially found downregulated both in L-02 cells and mouse livers and expression levels of ALAS1 and BCRP were elevated in L-02 cells after INH/RFP treatment, indicating FECH inhibition and ALAS1 induction might confer a synergistic effect on PPIX accumulation. Additionally, our results revealed that curcumin alleviated INH/RFP-induced liver injury, declined PPIX levels and induced FECH expression in both L-02 cells and mice. In conclusion, our data provide a novel insight in the mechanism of INH/RFP-induced PPIX accumulation and evidence for understanding pathogenesis of INH/RFP-induced liver injury, and suggest that amelioration of PPIX accumulation might be involved in the protective effect of curcumin on INH/RFP-induced liver injury.
Проблемы гендерного подхода в уголовном праве
Creators: name: Асият Абдуллаховна КАСУМОВА
Publisher: name: Закон и право
Year: 2020
Subjects: гендер
гендерная ассиметрия
пол
преступление
уголовно-правовые отношения
равноправие.

description: В статье рассматриваются проблемы гендерного подхода в уголовном и уголовнопроцессуальном законодательстве, практика применения уголовного закона по гендерному признаку на всех этапах развития уголовного права в различных государствах. Приведены исследования правоведов, высказана возможность использования гендерного подхода в современном уголовном и уголовно-исполнительном законодательстве.
Survey of discomfort glare from the headlamps of cars widely used in Iran
Creators: name: Mehri, Ahmad
name: Somayeh Farhang Dehghan
name: Roohalah Hajizadeh
name: Zakerian, Seyed Abolfazl
name: Mohammadi, Hamzeh
name: Abbasi, Milad
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences

description: Objective: On 2-lane roads, discomfort glare can cause annoyance, discomfort, inconvenience, stress, and fatigue to drivers, posing a risk of accidents. The aim of this study is to evaluate discomfort glare from the headlamps of cars widely used in Iran. Methods: The discomfort glare of new vehicles including Pride Saba model GTX, Pride Model 131SL, Samand Soren, Peugeot 405, Megane, and Peugeot Pars was examined at distances of 5 to 100 m at a background luminance of 50 cd/m2 (late twilight/early dawn lighting) and 1 cd/m2 (nighttime) using Schmidt-Clausen and Bindels model and de Boer's subjective scale. Results: According to the de Boer scale, at a background luminance of 50 cd/m2, the discomfort glare for all studied vehicles was between 1.98 and 4.05 in high-beam mode and between 3.5 and 5.4 in low-beam mode. At a background luminance of 1 cd/m2, discomfort glare was between 0.41 and 2.48 in high-beam mode and between 1.93 and 3.84 in low-beam mode. In high-beam mode, the average levels of discomfort glare of these vehicles gradually increased when the distance between cars was reduced by up to about 20 m. In low-beam mode, there was no discomfort glare up to a vehicle distance of 40 m. In addition, at an angle of 1.15°–5.73° between the line of sight and light of vehicles in high-beam mode, the level of discomfort glare was increased, but at an angle of 5.73°–22.9° the level of discomfort glare was reduced. In low-beam mode at an angle of 2.86°–22.9°, the level of discomfort glare was almost identical. The results show that in high-beam mode and with a 100-m distance between vehicles as well as in low-beam mode at intervals of less than 40 m between cars, discomfort glare is created. Conclusion: It can be concluded that by providing solutions such as installing road lighting system, an increase in luminance of roads, separating or widening road lanes, increasing the lateral distance between vehicles, and increasing the angle between lighted vehicles and drivers can noticeably reduce discomfort glare.
title: [Sermones]; [Anfang 15. Jahrhundert]
title: (1r) Sermones de sanctis, de tempore et de communi sanctorum. (133v) Sermones de tempore et de sanctis.
titleType: Subtitle
Creators: name: (:Unav)
Publisher: name: Universitätsbibliothek der Ludwig-Maximilians-Universität München
Year: 2023

description: Kurzaufnahme einer Handschrift = 4° Cod.ms. 878
Density-functional based tight-binding for the study of CO2/MOF interactions: the case of Zn(ADC)·DMSO
Creators: name: Li, Jie
name: Foster, Michael E.
name: Sohlberg, Karl
Publisher: name: Taylor & Francis
Year: 2017
Subjects: Biophysics
Biochemistry
Space Science
Medicine
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified

description: The adsorption of CO2 on the metal–organic framework, Zn(ADC) · DMSO, is studied using density functional-based tight-binding calculations with empirical dispersion correction (DFTB-D). Validation calculations predict bulk structure parameters that are consistent with published X-ray structure data for the material. The method is further validated by showing that DFTB-D predicts surface structures and CO2 binding energies in good agreement with the results of DFT/PW91-D calculations for both Zn(ADC) · DMSO and Cu(BTC) · 3H2O. A corrugated 1 0 0 surface of Zn(ADC) · DMSO is proposed that avoids cleaving through any aromatic rings to form the slab when studying the surface adsorption of CO2. DFTB-D calculations of CO2/surface interactions are combined with an enhanced Langmuir-type adsorption model to investigate the adsorption efficiency of CO2 on the Zn(ADC) · DMSO surface. The dependence of this adsorption on particle size and shape, and its sensitivity to errors in the predicted binding energy on the order of the anticipated accuracy of the calculated binding energies are discussed. By comparison to DFT/PW91-D calculations, we conclude that DFTB-D is a cost-effective and reliable tool to predict adsorption behaviour for MOFs of this type. Finally, it is found that for this newly synthesised Zn · ADC MOF to attain a specific CO2 adsorption capacity comparable to that of conventional porous MOFs, its particle size must be decreased to the nanometer level.
Sex-specific vulnerabilities in human astrocytes underpin the differential impact of palmitic acid
Creators: name: Hidalgo-Lanussa, Oscar
name: Gonzalez  Santos, Janneth
name: BARRETO, GEORGE
Publisher: name: University of Limerick
Year: 2024
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences

description: Obesity and neurometabolic diseases have been linked to neurodegenerative diseases. Our hypothesis is that the endogenous estrogenic component of human astrocytes plays a critical role in cell response during lipotoxic damage, given that obesity can disrupt hormonal homeostasis and cause brain inflammation. Our findings showed that high concentrations of palmitic acid (PA) significantly reduced cell viability more in male astrocytes, indicating sex-specific vulnerabilities. PA induced a greater increase in cytosolic reactive oxygen species (ROS) production in males, while female astrocytes exhibited higher superoxide ion levels in mitochondria. In addition, female astrocytes treated with PA showed increased expression of antioxidant proteins, including catalase, Gpx-1 and Nrf2 suggesting a stronger cellular defence mechanism. Interestingly, there was a difference in the expression of estrogenic components, such as estrogen, androgens, and progesterone receptors, as well as aromatase and 5α-reductase enzymes, between males and females. PA induced their expression mainly in females, indicating a potential protective mechanism mediated by endogenous hormones. In summary, our findings highlight the impact of sex on the response of human astrocytes to lipotoxicity. Male astrocytes appear to be more susceptible to cellular damage when exposed to high concentrations of fatty acids.
Pyridine-incorporated cyclo[6]aramide for recognition of urea and its derivatives with two different binding modes
Creators: name: Kang, Kang
name: Huang, Wei
name: Fu, Yonghong
name: Chen, Lixi
name: Hu, Jinchuan
name: Ren, Yi
name: Feng, Wen
name: Yuan, Lihua
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Cell Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: A novel pyridine-incorporated cyclo[6]aramide is designed and synthesised for recognition of urea and its derivatives. Analysis of its single crystal structure reveals the presence of introverted amide NH protons and amide carbonyl groups that are supposed to contribute to the subsequent accommodation of neutral urea-related guest molecules via multiple hydrogen bonding interactions. Thiourea is found to be superior to urea in binding to the receptor. Particularly interesting is the observation of two binding modes in complexing urea/thiourea (contact mode) and ethylurea/diethylurea (threading mode) as supported by both NMR experiments and computational simulations. The finding of the threading mode may open up new opportunities for the development of pesudorotaxanes and related mechanically interlocked structures.
Основные направления совершенствования деятельности в особых условиях руководителей территориальных органов внутренних дел
Creators: name: Анатолий Федорович МАЙДЫКОВ
name: Андрей Анатольевич МАЙДЫКОВ
Publisher: name: Закон и право
Year: 2020
Subjects: территориальные органы внутренних дел
особые условия
организация деятельности руководителей территориальных органов внутренних дел в особых условиях

description: Статья посвящена организации деятельности руководителей территориальных органов внутренних дел в особых условиях.
К вопросу о юридически значимых обстоятельствах по делам о возмещении вреда, причиненного жизни или здоровью гражданина трудовым увечьем или профессиональным заболеванием
Creators: name: Ольга Вячеславовна СМИРНОВА
Publisher: name: Закон и право
Year: 2020
Subjects: возмещение вреда
размер возмещаемого вреда
дополнительные расходы

description: Статья посвящена некоторым вопросам, возникающим по делам о возмещении вреда жизни или здоровью, причиненного трудовым увечьем или профессиональным заболеванием.
A highly selective visual and fluorescent sensor for Pb2+ and Zn2+ and crystal structure of Cu2+ complex based-on a novel single-armed Salamo-type bisoxime
Creators: name: Dong, Yin-Juan
name: Li, Xia-Liang
name: Zhang, Yang
name: Dong, Wen-Kui
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Neuroscience
subject: Chemical Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Plant Biology

description: A novel single-armed Salamo-type bisoximes (H4L) has been designed and synthesised. An obvious colour change from yellow (H4L) to pale pink (HL-Pb2+) which can be visually observed by the naked eye in visible light. H4L can act as a fluorescent sensor for ratiometric recognition of Zn2+ with high selectivity and sensitivity. Crystallographic data of the [Cu(HL)(μ-OAc)Cu] reveals that the two Cu2+ ions are both penta-coordinated with square pyramidal geometries, and forms a 2D supramolecular plane structure by hydrogen bonding interactions. A new single-armed Salamo-type bisoxime compound (H4L) has been designed and synthesised. An obvious colour change from yellow (H4L) to pale pink (HL-Pb2+) can be visually observed by the naked eye in visible light. H4L can act as a fluorescent sensor for ratiometric recognition of Zn2+ with high selectivity and sensitivity. Crystallographic data of the complex [Cu(HL)(μ-OAc)Cu] forms a 2D supramolecular network by hydrogen bonding interactions.
Effects of KF Loading on Mg–Al Mixed Oxides for the Selective Synthesis of Trimethylolpropane Triesters
Creators: name: Surapoj Katekong
name: Suchada Butnark
name: Chawalit Ngamcharussrivichai
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology

description: A series of Mg–Al hydrotalcites (HTCs) calcined at different temperatures were evaluated for their suitability as solid base catalysts for the selective synthesis of trimethylolpropane triesters (TMPTEs) via transesterification of trimethylolpropane (TMP) with a mixture of C8–C10 fatty acid methyl esters (FAMEs). The effect of potassium fluoride (KF) loading of the calcined HTCs on the physicochemical and catalytic properties of the materials attained was ascertained. Using a 5 wt% catalyst loading and a FAME:TMP molar ratio of 3.5:1 at 170°C for 8 h, the Mg–Al mixed oxide obtained by calcining HTC at 500°C (HTC-500) gave the highest TMPTE selectivity and FAME conversion. Impregnating HTC-500 with 10 wt% KF (KF/HTC-500) generated strongly basic KMgF3, KOH, K2O, and coordinatively unsaturated F− sites. The FAME conversion and TMPTE yield obtained over different HTC and KF/HTC-500 catalysts depended on their total basicity, where a basic strength of 15 H_ 3, a common homogeneous base for the polyol ester production.
Multiple-site fragment deletion, insertion and substitution mutagenesis by modified overlap extension PCR
Creators: name: Zeng, Fanli
name: Zhang, Yujie
name: Zhang, Ze
name: Malik, Asrar Ahmad
name: Lin, Yibin
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Introducing various mutations at multiple specific sites within a gene requires multiple steps of DNA manipulation, which is the initial, but limiting step of protein structure–function studies. In the present work, we standardized a simple and fast procedure to perform site-directed mutagenesis, multiple-site fragment deletion, insertion and substitution mutagenesis by a modified version of overlap extension polymerase chain reaction (PCR). In this procedure, target genes divided into several fragments based on the site of mutagenesis are amplified and annealed with their complementary overhanging, followed by extension and amplification to full-length gene with expected mutation(s) by PCR. Vectors inserted with the modified target gene are screened by colony PCR. By using the standardized procedure, we have easily generated single-site mutations, replaced/deleted DNA fragment into/from a target gene and engineered a cysteine-free protein. Practically, the standardized procedure provides an efficient choice for almost all kinds of mutagenesis, especially for multiple-site and large DNA fragment modification mutagenesis. Therefore, this method can be utilized to analyze protein structure and function, to optimize codons of genes for protein expression and to assemble genes of interest.
[Cu]-Catalyzed Direct Coupling of Dibromoalkenes: Synthesis of Symmetrical 1,3-Diynes and Triazoles
Creators: name: Lodi Mahendar
name: Bokka Venkat Ramulu
name: Gedu Satyanarayana
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified

description: An efficient [Cu]-catalyzed homo-coupling of 1,1-dibromoalk-1-enes, is described, for the synthesis of symmetrical 1,3-diyines. The method showed good substrate scope and amenable to aryl and heteroaryl systems. Significantly, the strategy was also successfully applied to the sequential one-pot synthesis of triazoles.
title: Τεχνικές της μηχανικής μάθησης για την βελτιστοποίηση των ευρυζωνικών δικτύων
title: Learning engineering techniques for the optimization of broadband networks
titleType: AlternativeTitle
Creators: name: Φουράκης, Βασίλειος
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2024
Subjects: Μηχανική μάθηση
Ευρυζωνικά δίκτυα
Εκμάθηση αλγορίθμων
Πρόβλεψη
Ταξινόμηση

description: Η συνεχή ζήτηση των χρηστών για ταχύτερες συνδέσεις, ποιοτικότερες και σταθερές υπηρεσίες και οι νέες τεχνολογίες του σήμερα, ανάγκασαν τους φορείς να αναπτύξουν τεχνικές για την ευρυζωνική κάλυψη, αξιοπιστία και ταχύτητα στην λήψη και μεταφορά των δεδομένων. Η ανάπτυξη των κέντρων δεδομένων, οι νέες τεχνολογίες οπτικών ινών και τα δίκτυα πέμπτης γενιάς, είναι από τις πιο σύνηθες τεχνολογίες, οι οποίες χρησιμοποιούνται καθημερινά από τους χρήστες για την κάλυψη των αναγκών τους. Συχνά υπάρχει το φαινόμενο της συμφόρησης λόγω υψηλής ζήτησης των υπηρεσιών ή μεγάλη κίνηση ροής, η οποία διαφέρει κατά την περιοχή και το χρονικό διάστημα. Επιπλέον η διαχείριση των πόρων αλλά και οι προτεραιότητες που θα δοθούν στους χρήστες, συνδέονται άμεσα με την τοπολογία, την χρήση, τους συνδρομητές που είναι ήδη στο αντίστοιχο δίκτυο και τις υπηρεσίες. Σημαντική επίσης είναι και η επεκτασιμότητα των διαθέσιμων κέντρων δεδομένων, για την ευελιξία και αξιοπιστία των δικτύων και των κέντρων. Επιπλέον η υψηλή κατανάλωση ενέργειας, έχει κάνει τους επιστήμονες να επικεντρωθούν σε νεότερες τεχνολογίες, οι οποίες θα μας επιφέρουν υψηλότερες επιδόσεις με μικρότερη κατανάλωση ενέργειας. Γενικότερα, όλες αυτές τις αναφερόμενες προκλήσεις, μπορούμε να τις προσεγγίσουμε και να τις διαχειριστούμε αποτελεσματικά μέσω της μηχανικής μάθησης, η οποία θα μπορεί σε πραγματικό χρόνο να ταξινομεί, να φιλτράρει και να επαναυπολογίζει διαδρομές στην ροή, ώστε να μπορούν να οριστούν τόσο οι αρχιτεκτονικές, για την δημιουργία του αντίστοιχου δικτύου, όσο και οι πόροι που θα χρειαστούν.
MIR506 induces autophagy-related cell death in pancreatic cancer cells by targeting the STAT3 pathway
Creators: name: Sun, Longhao
name: Hu, Limei
name: Cogdell, David
name: Lu, Li
name: Gao, Chao
name: Tian, Weijun
name: Zhang, Zhixiang
name: Kang, Ya'an
name: B. Fleming, Jason
name: Zhang, Wei
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive and lethal cancer. The role of autophagy in the pathobiology of PDAC is intricate, with opposing functions manifested in different cellular contexts. MIR506 functions as a tumor suppressor in many cancer types through the regulation of multiple pathways. In this study, we hypothesized that MIR506 exerted a tumor suppression function in PDAC by inducing autophagy-related cell death. Our results provided evidence that downregulation of MIR506 expression was associated with disease progression in human PDAC. MIR506 triggered autophagic flux in PDAC cells, which led to autophagy-related cell death through direct targeting of the STAT3 (signal transducer and activator of transcription 3)-BCL2-BECN1 axis. Silencing and inhibiting STAT3 recapitulated the effects of MIR506, whereas forced expression of STAT3 abrogated the effects of MIR506. We propose that the apoptosis-inhibitory protein BCL2, which also inhibits induction of autophagy by blocking BECN1, was inhibited by MIR506 through targeting STAT3, thus augmenting BECN1 and promoting autophagy-related cell death. Silencing BECN1 and overexpression of BCL2 abrogated the effects of MIR506. These findings expand the known mechanisms of MIR506-mediated tumor suppression to activation of autophagy-related cell death and suggest a strategy for using MIR506 as an anti-STAT3 approach to PDAC treatment.
Basic meteo at Las Tablas de Daimiel National Park (1992-2016)
Creators: name: [Unknown]
Publisher: name: FZ-Juelich B2SHARE
Year: 2020

description: Basic meteorologic data from authomatic weather stations (MeteoAutoTDNP_1: GEONICA METEODATA 256 [1992-1999; Currently not in operation], MeteoAutoTDNP_2: METEODATA/HYDRODATA 1256C [2001-]). Values recorded at 10 min intervals and then averaged for daily data (mean or sum).
title: Σολάριουμ, τεχνική, υγειονομική, νομοθετική και οικονομική μελέτη
title: Solarium, technical, sanitary, legislative and economical study
titleType: AlternativeTitle
Creators: name: Kιζερόπουλος, Κωσταντίνος Μάριος
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2024
Subjects: Τεχνητό μαύρισμα
Κρεβάτια μαυρίσματος
Ηλιακή ακτινοβολία
Κέντρα μαυρίσματος
Solarium

description: Σκοπός της εργασίας είναι να δώσει μια αντικειμενική και ολοκληρωμένη πληροφόρηση για το τι ακριβώς είναι και κάνει ένα κρεβάτι τεχνητού μαυρίσματος και να πραγματοποιήσει μία οικονομοτεχνική μελέτη για την δημιουργία ενός κέντρου solarium με δύο κρεβάτια. Μέσω επισκόπησης της επιστημονικής και μη βιβλιογραφίας εξετάζονται τα τεχνικά και λειτουργικά ζητήματα των κρεβατιών μαυρίσματος, οι βιολογικές επιδράσεις του solarium στον ανθρώπινο οργανισμό, και οι διαφορετικές απόψεις σχετικά με την εφαρμογή και την ασφάλεια αυτών των συστημάτων. Με την συνεργασία μεγάλης κατασκευαστικής εταιρείας solarium καταγράφηκαν και αναλύθηκαν οικονομικά και τεχνικά δεδομένα με στόχο την δημιουργία μιας οικονομοτεχνικής μελέτης ενός κέντρου solarium με δύο κρεββάτια μαυρίσματος. Η τεχνική, υγειονομική, και νομοθετική ανάλυση έδειξε ότι τα κρεββάτια μαυρίσματος παρουσιάζουν αρκετές ιδιαιτερότητες στην λειτουργία τους και απαιτούν εξειδικευμένο προσωπικό για την συντήρηση και τον τακτικό τους έλεγχο ώστε να εξασφαλίζεται η ασφαλής έκθεση στην UV ακτινοβολία ενώ επιτυγχάνεται το επιθυμητό αποτέλεσμα, είτε αισθητικό είτε θεραπευτικό. Ο μηχανικός βιοϊατρικής μπορεί να έχει ένα σημαντικό ρόλο και στην συντήρηση και στον έλεγχο των συστημάτων. Η οικονομοτεχνική μελέτη έδειξε ότι ένα κέντρο solarium μπορεί να είναι κερδοφόρο αρκεί να γίνει η σωστή έρευνα αγοράς και επιλογή σωστού χώρου που θα εξασφαλίσει τον απαιτούμενο αριθμό συνεδριών έτσι ώστε να γίνει η απόσβεση μέσα σε 10ετία.
Виды поведенческих стратегий адвоката в корпоративной системе управления конфликтами
Creators: name: Павел Валентинович СМИРНОВ
Publisher: name: Закон и право
Year: 2020
Subjects: конфликт интересов
поведенческие стратегии
адвокат
управление конфликтом

description: Статья посвящена поведению адвоката в рамках управления конфликтами интересов. Автором обозначены ключевые элементы стратегий поведения как факторы, формирующие конкурентные преимущества на рынке юридических услуг. Выделены виды поведенческих стратегий в рамках работы с конфликтами интересов на различных стадиях их формирования. Цель данной статьи — анализ составляющих поведенческих стратегий и их вариаций с целью выявления ситуаций возможного применения. Актуальность исследования состоит в потребности компаний в условиях растущей конкурентности на рынке юридических услуг управлять конфликтами интересов, безукоризненно следовать нормам права и этики в отношении поведения адвокатов, не допуская репутационных рисков. По результатам проведенной работы можно сделать вывод о том, что юридические фирмы должны оперировать не только различными стратегиями поведения в работе с корпоративными клиентами, но и тщательно прорабатывать элементы стратегий.
title: Έξυπνες εφαρμογές γεωργίας ακριβείας στο πλαίσιο του Διαδικτύου των Αντικειμένων
title: Smart agricultural applications in the context of the IoT
titleType: AlternativeTitle
Creators: name: Λαζάρου, Αναστάσιος
Publisher: name: Πανεπιστήμιο Δυτικής Αττικής
Year: 2024
Subjects: IoT
AI
Microcontroller
Agriculture
Web services
Climate change

description: Η παρούσα διπλωματική εργασία με θέμα «Έξυπνες εφαρμογές γεωργίας ακριβείας στο πλαίσιο του διαδικτύου των αντικειμένων" εκπονήθηκε στα πλαίσια του προγράμματος σπουδών του τμήματος Μηχανικών πληροφορικής και Υπολογιστών του Πανεπιστημίου Δυτικής Αττικής και εμπίπτει στα γνωστικά αντικείμενα των μαθημάτων διαδίκτυο των αντικειμένων, δίκτυα κινητών επικοινωνιών, προηγμένες δικτυακές τεχνολογίες, τεχνολογία και προγραμματισμός κινητών συσκευών. Σκοπός της διπλωματικής είναι η καταγραφή και η κατανόηση των υπαρχόντων μεθόδων γεωργίας , τα προβλήματα που αντιμετωπίζουν , πως επηρεάζονται από τις καιρικές και περιβαλλοντικές μεταβολές που φέρνει η κλιματική αλλαγή και πως μπορεί η τεχνολογία να βοηθήσει στην αντιμετώπισή τους. Επίσης η διπλωματική περιλαμβάνει τη σχεδίαση ενός έξυπνου συστήματος καταγραφής, ενημέρωσης και προειδοποίησης χρήστη (αγρότη) για τη κατάσταση της καλλιέργειάς του και στη συνέχεια με τη χρήση αλγορίθμων μηχανικής μάθησης τη πρόβλεψη για επικείμενα γεγονότα με σκοπό την αποφυγή κατανάλωσης περιττών πόρων (π.χ. πότισμα σε ήδη υγρό έδαφος κ.α.). Τέλος το έξυπνο σύστημα είναι το ελάχιστο βιώσιμο προϊόν, δηλαδή φέρει τα ελάχιστα δυνατά χαρακτηριστικά για να είναι λειτουργικό με σκοπό τη σταδιακή ανάπτυξή του. Οι βασικές τεχνολογίες που χρησιμοποιήθηκαν για τη σχεδίαση και την ανάπτυξη του συστήματος είναι: Arduino, Sensors, C, Python3, ThingsBoard, Nitro, Docker, Vue3(Javascript), Vuetify3, HTML,CSS.
Правозащитная функция прокуратуры Российской Федерации
Creators: name: Денис Юрьевич ПАРШУНИН
Publisher: name: Закон и право
Year: 2020
Subjects: Прокуратура РФ
правозащитная функция прокуратуры
функции прокуратуры
прокурорский надзор за соблюдением прав и свобод граждан
акты прокурорского реагирования

description: Статья посвящена характеристике правозащитной функции прокуратуры, ее сущности и отличительным особенностям. Целью выступает рассмотрение правозащитной функции прокуратуры, участие прокурора в гражданском и арбитражном процессе с целью защиты законных интересов, прав и свобод граждан, анализ актов прокурорского реагирования на нарушения закона. При помощи таких методов научного познания, как сравнительно-правовой метод и метод формализации, проанализированы нормативно-правовые акты и научная литература по рассматриваемой проблематике, сопоставлены составные части (элементы) правозащитной функции прокуратуры
MitoQ regulates autophagy by inducing a pseudo-mitochondrial membrane potential
Creators: name: Sun, Chao
name: Liu, Xiongxiong
name: Di, Cuixia
name: Wang, Zhenhua
name: Mi, Xiangquan
name: Liu, Yang
name: Zhao, Qiuyue
name: Mao, Aihong
name: Chen, Weiqiang
name: Gan, Lu
name: Zhang, Hong
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Cell Biology
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer

description: During the process of oxidative phosphorylation, protons are pumped into the mitochondrial intermembrane space to establish a mitochondrial membrane potential (MMP). The electrochemical gradient generated allows protons to return to the matrix through the ATP synthase complex and generates ATP in the process. MitoQ is a lipophilic cationic drug that is adsorbed to the inner mitochondrial membrane; however, the cationic moiety of MitoQ remains in the intermembrane space. We found that the positive charges in MitoQ inhibited the activity of respiratory chain complexes I, III, and IV, reduced proton production, and decreased oxygen consumption. Therefore, a pseudo-MMP (PMMP) was formed via maintenance of exogenous positive charges. Proton backflow was severely impaired, leading to a decrease in ATP production and an increase in AMP production. Excess AMP activates AMP kinase, which inhibits the MTOR (mechanistic target of rapamycin) pathway and induces macroautophagy/autophagy. Therefore, we conclude that MitoQ increases PMMP via proton displacement with exogenous positive charges. In addition, PMMP triggered autophagy in hepatocellular carcinoma HepG2 cells via modification of mitochondrial bioenergetics pathways.