cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Optimising desired gain indices to maximise selection response
Creators: name: Joukhadar, Reem
name: Li, Yongjun
name: Thistlethwaite, Rebecca
name: Forrest, Kerrie L
name: Tibbits, Josquin
name: Trethowan, Richard
name: Hayden, Matthew
Publisher: name: La Trobe
Year: 2024
Subjects: classificationCode: 3004
subject: Crop and pasture production
classificationCode: 30
subject: Agricultural, veterinary and food sciences
classificationCode: 3108
subject: Plant biology

description: Introduction: In plant breeding, we often aim to improve multiple traits at once. However, without knowing the economic value of each trait, it is hard to decide which traits to focus on. This is where “desired gain selection indices” come in handy, which can yield optimal gains in each trait based on the breeder’s prioritisation of desired improvements when economic weights are not available. However, they lack the ability to maximise the selection response and determine the correlation between the index and net genetic merit. Methods: Here, we report the development of an iterative desired gain selection index method that optimises the sampling of the desired gain values to achieve a targeted or a user-specified selection response for multiple traits. This targeted selection response can be constrained or unconstrained for either a subset or all the studied traits. Results: We tested the method using genomic estimated breeding values (GEBVs) for seven traits in a bread wheat (Triticum aestivum) reference breeding population comprising 3,331 lines and achieved prediction accuracies ranging between 0.29 and 0.47 across the seven traits. The indices were validated using 3,005 double haploid lines that were derived from crosses between parents selected from the reference population. We tested three user-specified response scenarios: a constrained equal weight (INDEX1), a constrained yield dominant weight (INDEX2), and an unconstrained weight (INDEX3). Our method achieved an equivalent response to the user-specified selection response when constraining a set of traits, and this response was much better than the response of the traditional desired gain selection indices method without iteration. Interestingly, when using unconstrained weight, our iterative method maximised the selection response and shifted the average GEBVs of the selection candidates towards the desired direction. Discussion: Our results show that the method is an optimal choice not only when economic weights are unavailable, but also when constraining the selection response is an unfavourable option.
Genetic testing : help, hope or hype : proceedings of the 15th Annual Health Policy Conference of the Centre for Health Services and Policy Research, November 8, 2002
Creators: name: Baird, Patricia A.
name: Williams-Jones, Bryn
Publisher: name: Centre for Health Services and Policy Research (CHSPR)
Year: 2014

description: The rapidly increasing numbers of genetic tests—generated in part by the identification of genes through the Human Genome Project, along with their patenting and commercialization by biotechnology and pharmaceutical companies—means there are key ethical, legal, and policy questions to be examined and their policy implications assessed by academics, policy-makers and practitioners. For example: • When are genetic tests indicated (and which type)? Who should pay for them? Whom should they be offered to? • Who should have access to the results? What are the equity implications for access to services? • What are the effects on the sustainability of the health care system? What are the effects on social justice of private markets for testing? These and other related questions were explored during the Centre for Health Services and Policy Research 2002 conference, “Genetic Testing: Help, Hope or Hype?”
AN UNUSUAL CAUSE OF ACUTE LOWER GASTROINTESTINAL BLEEDING
Creators: name: V Anumakonda
name: H Bu-Hayee
name: G Chung-Faye
name: Diaz-Cano, Salvador J.
Publisher: name: figshare
Year: 2012
Subjects: Medicine

description: Case Report: A 36-year-old presented with abdominal cramps, diarrhoea and several episodes of profuse rectal bleeding (1 week duration). No associated fever sweats or weight loss. He was haemodynamically stable. He had mild left iliac fossa tenderness, no organomegaly and bowel sounds were normal. Digital rectal examination revealed some fresh blood but no haemorrhoids and a normal prostrate. Other systems were unremarkable. Investigations: c-RP 10 mg/l, Hb 13.5 g/dl, WBC 8.34×103/mm3, and platelets 162×103/mm3. Multiple stool cultures were negative. A flexible sigmoidoscopy demonstrated blue lesions in the recto-sigmoid area, confluent inflammation of the descending and sigmoid colon, and relative rectal sparing, with ulceration. The histopathology specimens revealed ischaemic colitis with red cell extravasation, haemosiderin deposition and fibrosis. Mesalazine was discontinued. The patient had no further rectal bleeding and remained asymptomatic during his follow up over 6 months. This is first reported association of ischaemic colitis with Blue Rubber Bleb Nevus (BRBS) syndrome. BRBN are cavernous haemangioma lined by single layer of endothelium surrounded by thin connective tissue.1 The fragility of thin wall may predispose to further bleeding into submucosa compromise the vascular supply. BRBNS is managed conservatively with iron replacement therapy and transfusions. Endoscopic laser photocoagulation, systemic treatment with corticosteroids, interferon and vincristine may also be effective.2 Subcutaneous octreotide in the presence of active lesion proliferation or DIC has been used successfully.3,4 Skin lesions have been treated with the neodymium: YAG laser.5
Assessment of TGx-DDI genes for genotoxicity in a comprehensive panel of chemicals
Creators: name: Barutcu, A. Rasim
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology

description: The TGx-DDI biomarker identifies transcripts specifically induced by primary DNA damage. Profiling similarity of TGx-DDI signatures can allow clustering compounds by genotoxic mechanism. This transcriptomics-based approach complements conventional toxicology testing by enhancing mechanistic resolution. Unsupervised hierarchical clustering and t-distributed stochastic neighbor embedding (tSNE) were utilized to assess similarity of publicly-available per- and polyfluoroalkyl substances (PFAS) and ToxCast chemicals based on TGx-DDI modulation. TempO-seq transcriptomic data after highest chemical concentrations were analyzed. Clustering discriminated between genotoxic and non-genotoxic compounds while drawing similarity among chemicals with shared mechanisms. PFAS largely clustered distinctly from classical mutagens. However, dynamic range across PFAS types and durations indicated variable potential for DNA damage. tSNE visualization reinforced phenotypic groupings, with genotoxins clustering separately from non-DNA damaging agents. Unsupervised learning approaches applied to TGx-DDI profiles effectively categorizes chemical genotoxicity potential, aiding elucidation of biological response pathways. This transcriptomics-based strategy gives further insight into the role and effect of individual TGx-DDI biomarker genes and complements existing assays by enhancing mechanistic resolution. Overall, TGx-DDI biomarker profiling holds promise for predictive safety screening.
Obesity aggravates neuroinflammatory and neurodegenerative effects of bisphenol A in female rats
Creators: name: Mangla, Anuradha
name: Goswami, Poonam
name: Sharma, Bhaskar
name: Suramya, Suramya
name: Jindal, Garima
name: Javed, Mehjbeen
name: Saifi, Mohd. Anas
name: Parvez, Suhel
name: Nag, Tapas Chandra
name: Sheikh Raisuddin
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Physiology
subject: Chemical Sciences not elsewhere classified
subject: Science Policy
subject: Mental Health

description: Bisphenol A (BPA), a common plasticizer, is categorized as a neurotoxic compound. Its impact on individuals exhibits sex-linked variations. Several biological and environmental factors impact the degree of toxicity. Moreover, nutritional factors have profound influence on toxicity outcome. BPA has been demonstrated to be an obesogen. However, research on the potential role of obesity as a confounding factor in BPA toxicity is lacking. We studied the neurodegenerative effects in high-fat diet (HFD)-induced obese female rats after exposure to BPA (10 mg/L via drinking water for 90 days). Four groups were taken in this study – Control, HFD, HFD + BPA and BPA. Cognitive function was evaluated through novel object recognition (NOR) test. Inflammatory changes in brain, and changes in hormonal level, lipid profile, glucose tolerance, oxidative stress, and antioxidants were also determined. HFD + BPA group rats showed a significant decline in memory function in NOR test. The cerebral cortex (CC) of the brain showed increased neurodegenerative changes as measured by microtubule-associated protein-2 (MAP-2) accompanied by histopathological confirmation. The increased level of neuroinflammation was demonstrated by microglial activation (Iba-1) and protein expression of nuclear factor– kappa B (NF-КB) in the brain. Obesity also caused significant (p < 0.05) increase in lipid peroxidation accompanied by reduced activities of antioxidant enzymes (glutathione S-transferase, catalase and glutathione peroxidase) and decrease in reduced-glutathione (p < 0.05) when compared to non-obese rats with BPA treatment. Overall, study revealed that obesity serves as a risk factor in the toxicity of BPA which may exacerbate the progression of neurological diseases.
Assessment of TGx-DDI Genes for Genotoxicity in a Comprehensive Panel of Chemicals
Creators: name: Barutcu, A. Rasim
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Cancer
subject: Plant Biology

description: Background: The TGx-DDI biomarker identifies transcripts specifically induced by primary DNA damage. Profiling similarity of TGx-DDI signatures can allow clustering compounds by genotoxic mechanism. This transcriptomics-based approach complements conventional toxicology testing by enhancing mechanistic resolution. Method: Unsupervised hierarchical clustering and t-distributed stochastic neighbor embedding (tSNE) were utilized to assess similarity of publicly-available per- and polyfluoroalkyl substances (PFAS) and ToxCast chemicals based on TGx-DDI modulation. TempO-seq transcriptomic data after highest chemical concentrations were analyzed. Results: Clustering discriminated between genotoxic and non-genotoxic compounds while drawing similarity among chemicals with shared mechanisms. PFAS largely clustered distinctly from classical mutagens. However, dynamic range across PFAS types and durations indicated variable potential for DNA damage. tSNE visualization reinforced phenotypic groupings, with genotoxins clustering separately from non-DNA damaging agents. Discussion: Unsupervised learning approaches applied to TGx-DDI profiles effectively categorizes chemical genotoxicity potential, aiding elucidation of biological response pathways. This transcriptomics-based strategy gives further insight into the role and effect of individual TGx-DDI biomarker genes and complements existing assays by enhancing mechanistic resolution. Overall, TGx-DDI biomarker profiling holds promise for predictive safety screening.
Gesine Folyanty-Jost: Ökonomie und Ökologie in Japan. Politik zwischen Wachstum und Umweltschutz
Creators: name: Pascha, Werner
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 61 (1996): ASIEN (Oktober)
Flow-through imaging and automated analysis of oil-exposed early stage Atlantic cod (Gadus morhua)
Creators: name: Williamson, David R.
name: Davies, Emlyn J.
name: Ludvigsen, Martin
name: Hansen, Bjørn Henrik
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Medicine
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: Toxicology studies in early fish life stages serve an important function in measuring the impact of potentially harmful substances, such as crude oil, on marine life. Morphometric analysis of larvae can reveal the effects of such substances in retarding growth and development. These studies are labor intensive and time consuming, typically resulting in only a small number of samples being considered. An automated system for imaging and measurement of experimental animals, using flow-through imaging and an artificial neural network to allow faster sampling of more individuals, has been described previously and used in toxicity experiments. This study compares the performance of the automated imaging and analysis system with traditional microscopy techniques in measuring biologically relevant endpoints using two oil treatments as positive controls. We demonstrate that while the automated system typically underestimates morphometric measurements relative to analysis of manual microscopy images, it shows similar statistical results to the manual method when comparing treatments across most endpoints. It allows for many more individual specimens to be sampled in a shorter time period, reducing labor requirements and improving statistical power in such studies, and is noninvasive allowing for repeated sampling of the same population.
How we get to know what we know about alcohol. Book review: Vladimir Lovchev. Alcohol in European Culture. (2012). [Book review]. Tobacco Control and Public Health in Eastern Europe, 2(2), 109-110. doi:10.6084/m9.figshare.103125
Creators: name: Andreeva, Tatiana
Publisher: name: figshare
Year: 2012
Subjects: Medicine
History
Art
Literature

description: How we get to know what we know about alcohol. Book review: Vladimir Lovchev. Alcohol in European Culture. (2012). [Book review]. Tobacco Control and Public Health in Eastern Europe, 2(2), 109-110. doi:10.6084/m9.figshare.103125
Hagen Rudolph: Erfolgsfaktoren japanischer Großunternehmen. Die Bedeutung von Wettbewerb und individuellen Leistungsanreizen
Creators: name: Niehoff, Walter
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 61 (1996): ASIEN (Oktober)
Human oligodendroglial cells express low levels of C1 inhibitor and membrane cofactor protein mRNAs
Creators: name: Hosokawa, Masato
name: Klegeris, Andis
name: McGeer, Patrick L
Publisher: name: BioMed Central
Year: 2015

description: Background: Oligodendrocytes, neurons, astrocytes, microglia, and endothelial cells are capable of synthesizing complement inhibitor proteins. Oligodendrocytes are vulnerable to complement attack, which is particularly observed in multiple sclerosis. This vulnerability may be related to a deficiency in their ability to express complement regulatory proteins. Methods This study compared the expression level of complement inhibitor mRNAs by human oligodendrocytes, astrocytes and microglia using semi-quantitative RT-PCR. Results Semi-quantitative RT-PCR analysis showed that C1 inhibitor (C1-inh) mRNA expression was dramatically lower in oligodendroglial cells compared with astrocytes and microglia. The mRNA expression level of membrane cofactor protein (MCP) by oligodendrocytes was also significantly lower than for other cell types. Conclusion The lower mRNA expression of C1-inh and MCP by oligodendrocytes could contribute to their vulnerability in several neurodegenerative and inflammatory diseases of the central nervous system.
title: Lucerne :
title: Guidelines for the Conduct of Tests for Distinctness, Uniformity and Stability.
titleType: Subtitle
Creators: name: (:Unas)
Publisher: name: Unknown
Year: 2005

description: The purpose of these guidelines (“Test Guidelines”) is to elaborate the principles contained in the General Introduction (document TG/1/3), and its associated TGP documents, into detailed practical guidance for the harmonized examination of distinctness, uniformity and stability (DUS) and, in particular, to identify appropriate characteristics for the examination of DUS and production of harmonized variety descriptions.
Sentinel node in malignant melanoma – The pathologist’s point of view
Creators: name: Diaz-Cano, Salvador J.
Publisher: name: figshare
Year: 2012
Subjects: Medicine
Cancer

description: Overall, the benefit of accurate nodal staging obtained by SLN biopsy far outweighs the risks and has important implications for patient management. That is not to say that this test should be over-utilized. SLN biopsy is an extremely valuable tool to stratify a group of patients in which the standard prognostic factors have failed providing reliable information. Although SLN biopsy can still be considered a relatively “new” diagnostic tool, clear prognostic and therapeutic implications can be drawn when the samples are properly handle. The mRNA detection of melanoma-associated antigens (tyrosinase, MART-1, gp100, and others) remains experimental unless conclusive results on its clinical value are available. Finally, there are four major reasons to perform SLN biopsy. (1) SLN biopsy improves the accuracy of staging and provides valuable prognostic information. The “N classification” distinguishes between macroscopic and microscopic metastases. (2) SLN biopsy facilitates early therapeutic lymph node dissection for those patients with nodal metastases. (3) SLN biopsy identifies patients who are candidates for adjuvant therapy with interferon α-2b. (4) SLN biopsy identifies homogeneous patient populations for entry onto clinical trials of novel adjuvant therapy agents.
Fritsche, Klaus: Rußlands AuBenpolitik: Die asiatisch-pazifische Dimension Wacker, Gudrun: Die "chinesische Bedrohung": Wahn oder Wirklichkeit?
Creators: name: Glaubnitz, Joachim
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 61 (1996): ASIEN (Oktober)
Richtigstellungen zur Rezension meines Buches "Die Roten Khmer und der Dritte Indochina-Krieg" von Volker Grabowsky
Creators: name: Raszelenberg, Patrick
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 61 (1996): ASIEN (Oktober)
Health Care Utilization by Canadian Women
Creators: name: Kazanjian, Arminée, 1947-
name: Morettin, Denise
name: Cho, Robert
Publisher: name: BioMed Central
Year: 2015

description: Health Issues: While women are reported to be more frequent users of health services in Canada, differences in women's and men's health care utilization have not been fully explored. To provide an overview on women's healthcare utilization, we selected two key issues that are important for public policy purposes: access to care and patterns of utilization. These issues are examined using primarily data from the 1998/99 National Population Health Survey, complemented by the 2000 Canadian Community Health Survey and the 2001 Health Service Access Survey. Key Findings • Women are twice as likely as men to report a regular family physician, but that proportion is very low (15.8%). • Women report significantly shorter specialist wait times (20.9 days) than men (55.4 days) for mental health, while the reverse is true for asthma and other breathing conditions (10.8 for men, 78.8 for women). • Reported mean wait times are significantly lower for men than for women pertaining to overall diagnostic tests: for MRI, 70.3 days for women compared to 29.1 days for men. Data Gaps and Recommendations • Measurement of possible system bias and its implication for equitable and quality healthcare for women requires larger provincial samples of the national surveys, along with a longitudinal design. • Either a national database on preventive services, or better alignment of provincial databases pertaining to health promotion and preventive services, is needed to facilitate data linkage with national surveys to undertake longitudinal studies that support gender based analyses.
Clonality assays in adrenal medullary and thyroid C-cell proliferation
Creators: name: Diaz-Cano, Salvador J.
Publisher: name: figshare
Year: 2012
Subjects: Medicine
Molecular Biology
Cancer
Cell Biology

description: This review covers the role of RET protooncogene in the pathogenesis of thyroid C-cell and adrenal medullary cells proliferative lesions and the clonal and genetic evolution of these lesions, especially emphasizing the role of other genes. These key elements contribute to the molecular progression and intralesion heterogeneity of such lesions.
[Bladder transitional cell carcinoma rating, systematization of grading and value of DNA ploidy]
Creators: name: Hierro Martin I
name: Alvarez Perez M
name: Blanes A
name: Quiñonero Diaz A
name: Diaz-Cano, Salvador J.
name: Garcia Gonzalez I
name: Matilla A
Publisher: name: figshare
Year: 2012
Subjects: Medicine
Cancer
Cell Biology

description: TCCs are an heterogenous group of tumors with an uncertain biologic behaviour, especially intermediate grade (G2). Histologic grade and pathologic stage have revealed only partially useful on predicting the outcome.
Search and statement of objective and cuantitative parameters able to define prognostic subgroups to TCCs.
We studied consecutive 106 patients with TCC in order to: 1) Identify every variable with independent predictive value in classifying cases of TCC in a three (1,2,3) or two (high/low) grades systems. 2) Make a correlation between DNA ploidy obtained by image analysis and DNA ploidy and S-phase obtained by flow cytometry.
Every variable used to define the histologic grade showed significative correlation with both gradation systems. In multivariate analysis, the presence of superficial cells and the mitotic counts revealed us the most valuable variables in predicting the histologic grade. DNA-ploidy (both obtained by static an flow cytometry) correlated well with grade, stage, growth pattern and necrosis, whereas S-phase did so with grade, mitotic index and DNA ploidy. Image cytometry showed similars results to those of flow cytometry and also was able to detect aneuploidy when an situ carcinoma or dysplasia were present in the adyacent mucosa.
Does the accounting of the local symmetry fragments in quasi-SMILES improve the predictive potential of the QSAR models of toxicity towards tadpoles?
Creators: name: Toropova, Alla P.
name: Toropov, Andrey A.
name: Roncaglioni, Alessandra
name: Benfenati, Emilio
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Neuroscience
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified

description: Models of toxicity to tadpoles have been developed as single parameters based on special descriptors which are sums of correlation weights, molecular features, and experimental conditions. This information is presented by quasi-SMILES. Fragments of local symmetry (FLS) are involved in the development of the model and the use of FLS correlation weights improves their predictive potential. In addition, the index of ideality correlation (IIC) and correlation intensity index (CII) are compared. These two potential predictive criteria were tested in models built through Monte Carlo optimization. The CII was more effective than IIC for the models considered here.
L. L. Mehrotra, H. S. Chopra, Gert W. Kueck (eds.): SAARC 2000 and beyond. International seminar organised by India International Centre, Jawaharlal Nehru University, Konrad Adenauer Foundation.
Creators: name: Zingel, Wolfgang-Peter
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 61 (1996): ASIEN (Oktober)
NUMBЕRS IN ОLD TURKISH LАNGUАGЕ
Creators: name: Bаynаzаrоv Zоkir Аssistаnt Prоfеssоr in Sаmаrkаnd Stаtе Univеrsity Dоctоr оf Philоsоphy in Philоlоgy
Publisher: name: Zenodo
Year: 2024

description: Numеrаls аs а linguistic rеsоurcе аrе оnе оf thе аrеаs studiеd in linguistics. In thе Uzbеk lаnguаgе, аs in оthеr lаnguаgеs, thе numеrаl is cоnsidеrеd аs оnе pаrt оf spееch, аnd its linguistic fеаturеs, typеs аnd еxprеssiоns, its functiоn in thе spееch prоcеss, prаgmаtic аspеcts аrе studiеd in thе sciеncе оf linguistics. Thе histоry аnd еtymоlоgy оf numbеrs, which wе аrе аbоut tо tаlk аbоut, is аlsо а pаrtiаlly еxplоrеd аrеа with аn intеrеsting linguistic rеsеrvе. Thе linguistic аnd prаgmаtic fеаturеs оf thе studiеd numеrаls аlsо hаvе linguоculturаl аspеcts, аnd studying thеm аs linguistic mаtеriаl аlоng with sоciоculturаl аspеcts аlоng with еtymоlоgicаl аnаlysis prоvidеs mоrе sciеntific rеsults. Thеrеfоrе, in this smаll study, wе sеt а gоаl tо study numbеrs in thе histоry оf thе Uzbеk lаnguаgе, thеir linguоculturаl, linguоstаtisticаl аnd еtymоlоgicаl chаrаctеristics, аnd аs thе оbjеct оf study wе chоsе thе tеxts оf stоnе inscriptiоns crеаtеd in thе 7th-9th cеnturiеs. Sincе thе rеsеаrch оbjеct wе hаvе chоsеn is lаrgе-scаlе, wе triеd tо аnаlyzе оnly thе stаtistics оf thе usе оf primе numbеrs, sоciоculturаl chаrаctеristics аnd thе еtymоlоgy оf thеir оrigin frоm thе cоllеctеd mаtеriаls.

Kеy wоrds: numbеr, unit, dеcimаl, hundrеdth, stаtistics, еtymоlоgy, аnciеnt Turkic lаnguаgе, inscriptiоns оn stоnеs, numbеr functiоn, numbеr structurе, numbеrs
Improvement of the elk domestication technology at Sumarokovsky State Nature Reserve
Creators: name: Grachev, N.L.
name: Bourdeiniy, V.V.
name: Reshetnyak, V.V.
name: Volkhonov, M.S.
name: Elokhin, M.D.
name: Karenkova, N.G.
name: Kukhar, V.S.
Publisher: name: Agronomy Research
Year: 2020
Subjects: domestication
elk
elk farm
article

description: The paper discusses the technology of elk domestication and measures for its improvement at Sumarokovsky state nature reserve, the largest world center for the domestication of elks, as well as an environmental, research, cultural and educational institution. The article contains the data on ethological observations, the evolution of elk behavior in the conditions of ecological tourism, on elk keeping and on the conditions of the food base, on technological processes and suggests possible ways to correct them. It has the description of the organizational structure of the reserve, of the forestlands around and of their forage capacity; gives information about the vegetation composition, the mode of keeping and feeding elks. The reserve, due to its presence in a specially protected area, experiences significant restrictions on forest use on its territory, which leads to a deterioration and decrease in the area and quality of forage land for domesticated elks. The article shows the necessity of improving the regulatory framework as well as of the development and implementation of biotechnological measures to preserve and increase the forage capacity of frestland. It also shows that the technological chain of domestication makes it possible to get a controlled, stress-resistant, calm, friendly and safe animal, to carry out the selection period for the formation of dairy herds earlier, to obtain unique milk with both high nutritional and medicinal properties. Considering the fact that the largest number of domesticated elks in the world is concentrated in the reserve, the technology there is unique. Because of the potential danger of an elk as a source of human infection with various pathogens, the veterinary service requires intensification. It includes monitoring, development of treatment methods, drug application, prevention and control measures for diseases, provision of normative documents, etc. A change in the elk domestication technology under the increasing role of ecological tourism has led to the formation of a new economical type of a reserve, which combines elements of a stationary-exit, multidisciplinary and enclosure types.
The "Dramatic" Overture and the Idea of Tragic Narrative (Complete Thesis)
Creators: name: Fenby-Hulse, Kieran
Publisher: name: figshare
Year: 2012
Subjects: subject: History
subject: Art
subject: Philosophy
subject: FOS: Philosophy, ethics and religion
subject: Literature
subject: Performing Arts

description: This thesis consists of four chapters, each chapter presenting a case study of an overture from either the latter half of the eighteenth century or first decade of the nineteenth century, in particular overtures written between the years 1767 and 1809. The aim is to explore the relationship between the overture and the drama that it introduces. I assess whether an overture bears any relation to the ensuing drama and, if so, how the music of the overture is able to foster a sense of drama that is akin to that of the literary-based narrative that follows. In short, this thesis explores ideas of introduction, preparation, and expectation, and is as much concerned with ideas of music as drama and music as narrative, as it is with overtures. The four overtures I have chosen to focus upon each introduce either a tragedy or contain tragic scenes and/or subjects. By focusing my investigation on the idea of tragic narrative, I will be able to look in detail at the relationship between music, narrative and drama, and explore whether literary ideas particular to tragedy can inform the musical narrative of an overture. This thesis, then, is not so much a contribution to the history of the overture, than a contribution to the theory of music as narrative and, in particular, music as tragic narrative. More Info: This the complete version of my thesis which was AHRC Funded PhD and Awarded by King's College London on 1st November 2011
Prehospital Advanced Airway Management and Ventilation for Out-of-Hospital Cardiac Arrest with Prehospital Return of Spontaneous Circulation: A Prospective Observational Cohort Study in Japan
Creators: name: Nakayama, Ryuichi
name: Bunya, Naofumi
name: Uemura, Shuji
name: Sawamoto, Keigo
name: Narimatsu, Eichi
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Medicine
Biological Sciences not elsewhere classified
Science Policy

description: The relationship among advanced airway management (AAM), ventilation, and oxygenation in patients with out-of-hospital cardiac arrest (OHCA) who achieve prehospital return of spontaneous circulation (ROSC) has not been validated. This study was designed to evaluate ventilation and oxygenation for each AAM technique (supraglottic devices [SGA] or endotracheal intubation [ETI]) using arterial blood gas (ABG) results immediately after hospital arrival. This observational cohort study, using data from the Japanese Association for Acute Medicine OHCA Registry, included patients with OHCA with prehospital and hospital arrival ROSC between July 1, 2014, and December 31, 2019. The primary outcomes were the partial pressure of carbon dioxide in the arterial blood (PaCO2) and partial pressure of oxygen in the arterial blood (PaO2) in the initial ABG at the hospital for each AAM technique (SGA or ETI) performed by paramedics. The secondary outcome was favorable neurological outcome (cerebral performance category [CPC] 1 or 2) for specific PaCO2 levels, which were defined as good ventilation (PaCO2 ≤45 mmHg) and insufficient ventilation (PaCO2 >45 mmHg). This study included 1,527 patients. Regarding AAM, 1,114 and 413 patients were ventilated using SGA and ETI, respectively. The median PaCO2 and PaO2 levels were 74.50 mmHg and 151.35 mmHg in the SGA group, while 66.30 mmHg and 173.50 mmHg in the ETI group. PaCO2 was significantly lower in the ETI group than in the SGA group (12.55 mmHg; 95% CI 15.27 to 8.20, P-value < 0.001), while no significant difference was found in PaO2 by multivariate linear regression analysis. After stabilizing inverse probability of weighting (IPW), the adjusted odds ratio for favorable neurological outcome at 1 month was significant in the good ventilation group compared to the insufficient ventilation cohort (adjusted odds ratio = 2.12, 95%CI: 1.40 to 3.19, P value < 0.001). The study showed that in OHCA patients with prehospital ROSC, the PaCO2 levels in the initial ABG were lower in the group with AAM by ETI than in the SGA group. Furthermore, patients with prehospital ROSC and PaCO2 ≤45 mmHg on arrival had an increased odds of favorable neurological outcome after stabilized IPW adjustment.
Survival following Prehospital Traumatic Cardiac Arrest Resuscitation in the Israel Defense Forces: A Retrospective Study
Creators: name: Talmy, Tomer
name: Greenstein, Ithamar
name: Gendler, Sami
name: Chayen, David
name: Radomislensky, Irina
name: Ahimor, Alon
name: Koler, Tomer
name: Glassberg, Elon
name: Almog, Ofer
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Medicine
Biotechnology
Information Systems not elsewhere classified
Developmental Biology
Cancer

description: Prehospital traumatic cardiac arrest (TCA) is associated with a poor prognosis and requires urgent interventions to address its potentially reversible causes. Resuscitative efforts of TCA in the prehospital setting may entail significant resource allocation and impose added tolls on caregivers. The Israel Defense Forces Medical Corps (IDF-MC) instructs clinicians to perform a set protocol in the case of TCA, providing prompt oxygenation, chest decompression and volume resuscitation. This study investigates the settings, interventions, and outcomes of TCA resuscitation by IDF-MC teams over 25 years in both combat and civilian settings. Retrospective study of the IDF-MC Trauma Registry between 1997–2022. Search criteria were applied to identify cases where the TCA protocol was initiated. A manual review of cases matching the search criteria was performed by two curators to determine the indications, interventions, and outcomes of casualties with prehospital TCA. Patients for whom interventions were performed outside of the TCA protocol, such as with measurable vital signs, were excluded. The primary outcome was survival to hospital admission, with the secondary outcome being return of vital signs in the prehospital setting. Following case review, 149 patients with prehospital TCA were included, with a median age of 21 (interquartile range 19–27). Eighty-four (56.4%) presented with TCA in military or combat settings, with gunshot wounds and blast injuries being the most common mechanisms in this group. For 56 casualties (37.8%), all components of the protocol were performed (oxygenation, chest decompression, and volume resuscitation). Five (3.4%) casualties had return of vital signs in the prehospital setting, but none survived to hospital admission. The prognosis of prehospital TCA is poor, and efforts to address its potentially reversible causes may often be futile. These notions may be further emphasized in military settings, where resources are limited, and extensive penetrating injuries are more common.
Duden. Rechtschreibung in der deutschen Sprache. 21., völlig neu bearbeitete und erweiterte Auflage. Hrsg. Von der Dudenredaktion
Creators: name: Schucher, Günter
Publisher: name: ASIEN: The German Journal on Contemporary Asia
Year: 2021

description: ASIEN: The German Journal on Contemporary Asia, Nr. 61 (1996): ASIEN (Oktober)
The Association of Prehospital End-Tidal Carbon Dioxide with Survival Following Out-of-Hospital Cardiac Arrest
Creators: name: Smida, Tanner
name: Menegazzi, James J.
name: Crowe, Remle P.
name: Salcido, David D.
name: Bardes, James
name: Myers, Brent
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Medicine
Biological Sciences not elsewhere classified
Cancer
Science Policy

description: End tidal carbon dioxide (ETCO2) is often used to assess ventilation and perfusion during cardiac arrest resuscitation. However, few data exist evaluating the relationship between ETCO2 values and mortality in the context of contemporary resuscitation practices. We aimed to explore the association between ETCO2 and mortality following out-of-hospital cardiac arrest (OHCA). We used the 2018–2021 ESO annual datasets to query all non-traumatic OHCA patients with attempted resuscitation. Patients with documented DNR/POLST, EMS-witnessed arrest, ROSC after bystander CPR only, or < 2 documented ETCO2 values were excluded. The lowest and highest ETCO2 values recorded during the total prehospital interval, in addition to the pre- and post-ROSC intervals for resuscitated patients, were calculated. Multivariable logistic regression models adjusted for age, sex, initial rhythm, witnessed status, bystander CPR, etiology, OHCA location, sodium bicarbonate administration, number of milligrams of epinephrine administered, and response interval were used to evaluate the association between measures of ETCO2 and mortality. Hospital outcome data were available for 14,122 patients, and 2,209 (15.6%) were classified as surviving to discharge. Compared to patients with maximum prehospital ETCO2 values of 30–40 mmHg, odds of mortality were increased for patients with maximum prehospital ETCO2 values of <20 mmHg (aOR: 3.5 [2.1, 5,9]), 20–29 mmHg (aOR: 1.5 [1.1, 2.1]), and >50 mmHg (aOR: 1.5 [1.2, 1.8]). After 20 minutes of ETCO2 monitoring, <12% of patients had ETCO2 values <10 mmHg. This cutpoint was 96.7% specific and 6.9% sensitive for mortality. In this dataset, both high and low ETCO2 values were associated with increased mortality. Contemporary resuscitation practices may make low ETCO2 values uncommon, and field termination decision algorithms should not use ETCO2 values in isolation.
Integrating Ethnicity and Migration As Determinants of Canadian Women's Health
Creators: name: Vissandjee, Bilkis
name: Desmeules, Marie
name: Cao, Zheynuan
name: Abdool, Shelly
name: Kazanjian, Arminée
Publisher: name: BioMed Central
Year: 2016

description: Health Issue: This chapter investigates (1) the association between ethnicity and migration, as measured by length of residence in Canada, and two specific self-reported outcomes: (a) self-perceived health and (b) self-reports of chronic conditions; and (2) the extent to which these selected determinants provide an adequate portrait of the differential outcomes on Canadian women's self-perceived health and self-reports of chronic conditions. The 2000 Canadian Community Health Survey was used to assess these associations while controlling for selected determinants such as age, sex, family structure, highest level of education attained and household income. Key Findings: • Recent immigrant women (2 years or less in Canada) are more likely to report poor health than Canadian-born women (OR = 0.48 CI: 0.30–0.77). Immigrant women who have been in Canada 10 years and over are more likely to report poor health than Canadian-born women (OR = 1.31 CI: 1.18–1.45). • Although immigrant women are less likely to report chronic conditions than Canadian-born women, this health advantage decreased over time in Canada (OR from 0.35 to 0.87 for 0–2 years to 10 years and above compared with Canadian born women). Data Gaps and Recommendations: • Migration experience needs to be conceptualized according to the results of past studies and included as a social determinant of health above and beyond ethnicity and culture. It is expected that the upcoming longitudinal survey of immigrants will help enhance surveillance capacity in this area. • Variables need to be constructed to allow women and men to best identify themselves appropriately according to ethnic identity and number of years in the host country; some of the proposed categories used as a cultural group may simply refer to skin colour without capturing associated elements of culture, ethnicity and life experiences.
Modelling and Simulation of Supercritical CO2 Oil Extraction from Biomass
Creators: name: Filipe, Rui M.
name: Coelho, José A.P.
name: Villanueva-Bermejo, David
name: Stateva, Roumiana  P.
Publisher: name: Zenodo
Year: 2019
Subjects: Grape seeds
chia seeds
supercritical CO2 extraction
extraction kinetics
mathematical modelling

description: The aim of this work is to model the kinetics of the supercritical CO2 extraction of oils from biomass, namely from industrial grape seeds and chia seeds. A model introduced by Sovova and Stateva (2015) is used and solved using gPROMS ModelBuider. The
 supercritical extraction experiments performed at different temperature, pressure and flow rate conditions, provide the data to the modelling studies and for model parameter estimation, using gPROMS parameter estimation.
 The partition coefficient and the maximum oil content corresponding to monolayer adsorption was estimated and the absolute average relative deviation between the experimentally measured and simulated extraction curves for the cases examined is
 within the range (1-9) %, which may be considered as a good agreement taking into consideration the very complex nature of the systems under study.
THE ROLE OF USING DIGITAL EDUCATIONAL TECHNOLOGIES IN METHODICAL TRAINING OF FUTURE PRIMARY SCHOOL TEACHERS
Creators: name: Ruzimatov, Jamshid
Publisher: name: Zenodo
Year: 2024

description: The digitalization of all aspects of our life today, including the role of digital technologies in the integration of preschool and primary education, the role of digital technologies in the training of future personnel, and the problems of modern education were seen in the article.
Protocolo de Revisión sistemática: Comparación del Impacto entre la Atención del Parto Hospitalario y Domicili
Creators: name: Castillo Gonzalez, Antonia
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 429999
subject: Other health sciences not elsewhere classified

description: En la última década, el parto hospitalario se ha convertido en un recurso esencial para la protección del bienestar materno-fetal a nivel global, aunque ha generado debates y controversias. Hoy en día, aunque los partos domiciliarios planificados son más comunes en áreas rurales, siguen siendo raros en países como Estados Unidos. Esta investigación busca comparar el impacto de la atención hospitalaria y domiciliaria del parto, evaluando sus beneficios y riesgos, para informar las políticas de salud pública y las decisiones clínica.
BOLALAR UCHUN KUTUBXONA MEBELI DIZAYNI VA UNING KONSEPSIYASI.
Creators: name: Abdusalamova, Shahida
name: G'aybullayeva, Hafiza
Publisher: name: Zenodo
Year: 2024

description: Bolalar uchun yaratilgan har qanday mebel, bo’lmasin uning dizayniga etibor berish juda muhimdir. Sababi bolalar go’zallikni va rang-barang va shu bilan birga qiziqarli narsalarni juda yaxshi ko’rishadi. Dizayn sohasi kop qirrali sohalardan biri bolib hozirgi kunda zamon talabiga aylanib bormoqda. Xususan yurtimizda ham dizayn sohasiga e’tibor berila boshlangani quvonarli holdir. Ushbu maqolada bolalar kutubxona mebeli haqida qisqacha ma’lumot berib o’tdim.
The association of prehospital end-tidal carbon dioxide with survival following out-of-hospital cardiac arrest
Creators: name: Smida, Tanner
name: Menegazzi, James J.
name: Crowe, Remle P.
name: Salcido, David D.
name: Bardes, James
name: Myers, Brent
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Medicine
Biological Sciences not elsewhere classified
Cancer
Science Policy

description: Objective End tidal carbon dioxide (ETCO2) is often used to assess ventilation and perfusion during cardiac arrest resuscitation. However, few data exist on the relationship between ETCO2 values and mortality in the context of contemporary resuscitation practices. We aimed to explore the association between ETCO2 and mortality following out-of-hospital cardiac arrest (OHCA). Methods We used the 2018-2021 ESO annual datasets to query all non-traumatic OHCA patients with attempted resuscitation. Patients with documented DNR/POLST, EMS-witnessed arrest, ROSC after bystander CPR only, or < 2 documented ETCO2 values were excluded. The lowest and highest ETCO2 values recorded during the total prehospital interval, in addition to the pre- and post-ROSC intervals for resuscitated patients, were calculated. Multivariable logistic regression models adjusted for age, sex, initial rhythm, witnessed status, bystander CPR, etiology, OHCA location, sodium bicarbonate administration, number of milligrams of epinephrine administered, and response interval were used to evaluate the association between measures of ETCO2 and mortality. Results Hospital outcome data were available for 14,122 patients, and 2,209 (15.6%) were classified as surviving to discharge. Compared to patients with maximum prehospital ETCO2 values of 30-40 mmHg, odds of mortality were increased for patients with maximum prehospital ETCO2 values of <20 mmHg (aOR: 3.5 [2.1, 5,9]), 20-29 mmHg (aOR: 1.5 [1.1, 2.1]), and >50 mmHg (aOR: 1.5 [1.2, 1.8]). After 20 minutes of CPR, <12% of patients had ETCO2 values <10 mmHg. This cutpoint was 96.7% specific and 6.9% sensitive for mortality. Conclusion In this dataset, both high and low ETCO2 values were associated with increased mortality. Contemporary resuscitation practices may make low ETCO2 values uncommon, and field termination decision algorithms should not use ETCO2 values in isolation.
Deliverable D4.2 - First results of Use Cases implementation for eHE domain
Creators: name: Karanasiou, Gianna
name: Plakas, Dimitris
name: Maidonis, Nikos
name: Sintroris, Nikos
name: Stavroulaki, Vera
name: Bianzino, Aruna Prem
name: Sacco, Giancarlo
name: Piccinino, Mara
name: Iovanna, Paola
name: Bottari, Giulio
name: Di Giglio, Andrea
name: Moggio, Fabrizio
name: Tecchia, Franco
name: Villafranca, Silvia
name: Laurino, Marco
name: Benvenuti, Chiara
name: Maiettini, Elisa
name: Calabrese, Carmela
name: Tsakanika, Dimitra
name: Christantoni, Ilia
name: Spiliotis, Aristotelis
name: Loukea, Matina
Publisher: name: Zenodo
Year: 2024

description: The D4.2 is a public deliverable, elaborated in the context of Work Package 4 (WP4) operating in the eHealth and Emergency (eHE) domains. The activities of WP4 are carried out in the overall project framework mainly addressing two important objectives: to perform trials of the Beyond 5G (B5G) technology specifically devoted to eHE domains, supporting innovative applications (e.g., Remote Proctoring and Smart Ambulance) in large- scale environments (e.g., hospitals), and introducing societal benefits in the eHE areas to facilitate an early adoption of such new technologies.

While D4.1 defines the use cases (UC) in terms of their initial application design, components, and functionalities, along with the preliminary technical requirements and the definition of the related Key Performance Indicators (KPIs) and Key Value Indicators (KVIs), D4.2 outlines the project’s progress up to this point and focuses on reporting the initial implementation outcomes. The use cases within WP4 are organized into three main clusters, connecting expertise from Greece, Italy (Pisa site), and Spain. On such basis, for each use case, the deliverable provides a concise summary of the objectives and contexts, as well as a detailed explanation of the final application design and the preliminary integration and testing activities in terms of laboratory tests, on-field tests, and early demonstrations, shedding light on performance insights and potential challenges encountered during these activities. Finally, the document concludes with updates on the implementation plan for each use case, including a review of milestones and progress tracking.