cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Mass-conservative and positivity preserving second-order semi-implicit methods for high-order parabolic equations
Creators: name: Keita, Sana
name: Beljadid, Abdelaziz
name: Bourgault, Yves
Publisher: name: arXiv
Year: 2020
Subjects: subject: Numerical Analysis (math.NA)
subject: FOS: Mathematics

description: We consider a class of finite element approximations for fourth-order parabolic equations that can be written as a system of second-order equations by introducing an auxiliary variable. In our approach, we first solve a variational problem and then an optimization problem to satisfy the desired physical properties of the solution such as conservation of mass, positivity (non-negativity) of solution and dissipation of energy. Furthermore, we show existence and uniqueness of the solution to the optimization problem and we prove that the methods converge to the truncation schemes \cite{Berger1975}. We also propose new conservative truncation methods for high-order parabolic equations. A numerical convergence study is performed and a series of numerical tests are presented to show and compare the efficiency and robustness of the different schemes.
Οι κοινωνικές αιτίες της ανόδου του επαγγελματισμού και οι προοπτικές του εκπαιδευτικού επαγγέλματος:
Creators: name: Φυτιλή, Δήμητρα Γεωργίου
Publisher: name: Aristotle University of Thessaloniki
Year: 2009
Subjects: Καταμερισμός εργασίας
Επαγγελματισμός
Επαγγέλματα-professions-κοινωνιολογικές προσεγγίσεις
Επάγγελμα του εκπαιδευτικού
Επαγγελματική ανάπτυξη του εκπαιδευτικού
Επιμόρφωση του εκπαιδευτικού
Division of labor in society
Professionalism-professionalization
Professions, professionals
Teachers-is teaching a profession
Teacher education
Teacher professional development

description: Το θεωρητικό μέρος της εργασίας εξετάζει την ανάλυση των αιτιών της ανάπτυξης του επαγγελματισμού και της κοινωνικής ιεράρχησης των επαγγελμάτων, και εστιάζει στο επαγγελμα του εκπαιδευτικού. Το ερευνητικό μέρος εστιάζει στην ανάδειξη ττης προσωπικής θεωρίας του εκπαιδευτικού και στο πώς αντιλαμβάνεται ο έλληνας εκπαιδευτικός την επαγγελματική ανάπτυξη
description: The theoretical part of this thesis is concerned with tho subjects. It tries to explain the reason of the development of professionalism and it focuses on the division of labor in society. The second theme is the teacher professionalism. It is discussed why teachers are not reagarded as professionals in society and some ways that could lead to the teacher professional development are explored. The research focuses on the presentation of the teachers theory about their job. It is explored if and how the greek teachers long for their development
title: Defects in high-entropy alloys studied by atomic scale computer simulations
Creators: name: Utt, Daniel Thomas
Publisher: name: UNSPECIFIED
Year: 2022

description: High-entropy alloys (HEAs) are a new class of metal alloys containing multiple principal elements in concentrations between 5-35 at%. Due to their inherent chemical complexity, they possess a wide range of interesting properties, which we explore in greater detail throughout this thesis. Reduced or sluggish diffusion has been discussed for HEAs since their inception. We perform time-scale bridging simulations on the pseudo-binary (CoCrFeMn)_(1-x)Ni_x HEA, combining atomistic simulations of the vacancy migration energies and equilibrium vacancy concentrations with kinetic Monte Carlo simulations of tracer diffusion trajectories. Here, we extend the established random alloy model to account for the local chemical fluctuations within the complex alloy matrix. The results compare favorably to experimental tracer diffusion measurements. Dislocations in HEAs also interact with chemical fluctuations in the random matrix. This leads to a meandering dislocation line shape and localized pinning during dislocation glide. We find a physically motivated descriptor for these pinning sites in the form of a per-atom Peierls force. This descriptor shows good spatial correlation with observed dislocation pinning sites during glide. Furthermore, we show that the density of strong pinning sites in an alloy correlates not only with the critical shear required to initiate dislocation glide but also the dislocation mobility. We report on the grain growth properties of a CoCuFeNi model HEA. Atomistic simulations give unique insights into the effects of random chemical fluctuations by comparison of the HEA to its average-atom counterpart. The average-atom is a virtual element which has the same long-range properties as the alloy but consists only of a single element. Additionally, solute segregation to grain boundaries (GBs) is considered. The comparison of two different samples, namely a Sigma 11 GB and a large-scale nanocrystalline sample, reveals that while grain growth is reduced in the HEA compared to other pure metals, this does not stem from the chemical randomness. Instead, solute segregation is necessary to pin GBs up to high temperatures.
Οι μεταβυζαντινοί μελουργοί της Λέσβου και το έργο τους (μέσα ιε' αιώνα-μέσα ιθ' αιώνα):
Creators: name: Ιωακείμ, Ανδρέας Παναγιώτη
Publisher: name: Aristotle University of Thessaloniki
Year: 2008
Subjects: Μελουργός
Κωδικογράφος
Λέσβος
Μεταβυζαντινή (περίοδος)
(Ι.Μ.) Λειμώνος
Βυζαντινή (μουσική)
Composer
Manuscript
Lesvos
Post Byzantine
Leimonos (monastery)
Byzantine (music)

description: Η εργασία "Οι Μεταβυζαντινοί Μελουργοί της Λέσβου και το έργο τους" περιλαμβάνει δυο μέρη. Στο πρώτο μέρος παρουσιάζεται η Εισαγωγή η οποία αποσαφηνίζει αρκετά μουσικολογικά ζητήματα, χαρακτηρίζει τη Μεταβυζαντινή περίοδο μελουργίας και αναφέρεται σε ιστορικά και πολιτιστικά στοιχεία του νησιού καθώς και σε μια συνοπτική παρουσίαση όλων των Λέσβιων Μελουργών, ποιητών και κωδικογράφων. Το δεύτερο μέρος περιλαμβάνει 3 κεφάλαια. Το πρώτο αναφέρει τους μελουργούς που έδρασαν από τα μέσα του ιε' αιώνα (1470) μέχρι τα μέσα του ιζ' αιώνα (1670), ενώ το δεύτερο παρουσιάζει εκείνους που έδρασαν από τα μέσα του ιζ' αιώνα (1670) έως τις αρχές του ιθ' αιώνα (1814). Το τρίτο κατά σειρά κεφάλαιο περιλαμβάνει μορφολογική ανάλυση σημαντικών ανέκδοτων ύμνων, ορισμένων μάλιστα σε δεκαπεντασύλλαβη μορφή.
description: The work "The post Byzantine composers of Lesvos and their work" concludes two parts. In the first part there is the introduction which gives responses in many musical themes, characterizes the Post Byzantine composing period and refers to historic and civilizing elements of the island of Lesvos as well as to a short presentation all of the Lesbian composers, poets and the writers of the manuscripts. The second part concludes three chapters. The first refers to the composers who created their work from the middle xv century (1470) till middle xvii century (1670). The second chapter refers to those who created their work from the middle xvii century (1670) till the beginning xix century (1814). At least the third chapter concludes the analysis form of important hymns which haven't been published, some of them in fifteenth syllable form.
Propranolol treatment for children with hemangiomas – final report
Creators: name: Albuquerque, Juliana
name: Juvenia Fontenele
name: Felix, Francisco
Publisher: name: F1000Research
Year: 2015

description: Hemangiomas are benign vascular tumors more frequent in female, caucasian infants. They show a rapidly growing proliferative phase in the first months of life, followed by an involutive phase that ends with complete regression in two thirds of cases, at 3-5 years of age. Little is known about its biology and the molecular phenomena underlying these phases. Nonetheless, it is hypothesized that propranolol has an anti-angiogenic effect in the first, proliferative phase of its development. We have been treating patients with problematic hemangiomas since 2009 with off-label propranolol. In this report, we summarize the results of an observational retrospective study completed in our medical center.

We reviewed the charts of patients 0-19 years diagnosed with problematic vascular lesions with an initial classification as hemangiomas and treated with propranolol. Primary endpoint was response to treatment, evaluated by the comparison of the status at the beginning of treatment and at the last clinical evaluation. The comparison was either subjective (by inspection or photographs) and/or objective (by direct measuring or imaging with ultrasound or MRI). Patients without proper response evaluation were excluded. Response was classified according to WHO criteria (stable disease – less than 25% change, partial response, and complete response – more than 95% change).

Ninety four patients were included. Median follow-up time was 17 months. Propranolol dose ranged from 0.5 to 4 mg/kg/day q8-12h. Patients with a history of asthma were not treated with beta-blockers. Most patients (69%) were female and were confirmed with infantile hemangiomas (IH) (71%). A minority of patients were reclassified as congenital hemangioma (5%), IH in the setting of syndromic patients (7%) and undefined lesions (17%), some of the latter with histology of "cavernous hemangioma" or "diffuse hemangioma", one probably with a vascular malformation, and other with a lymphangioma. Response was as follows: IH – CR 39%, PR 43%, SD 18%; reclassified – CR 22%, PR 33%, SD 45%. Comparing the odds of responding between groups, we found that best responders were IH (OR = 0,26 CI = 0.1-0.7) and children under 1 year (OR = 0.1 CI = 0.04-0.31).

As a conclusion, we believe that there is evidence that children with more than 1 year of age (past the proliferative phase) lose most of the response potential. However, we still believe that a therapeutic course with propranolol after the proliferative phase is worth the shot in selected, complicated cases. We were intrigued by the possible potential for response in non-IH cases. Since the group of patients with reclassified lesions was small and heterogeneous it is premature to conclude anything. Nonetheless, it is possible that other vascular lesions may respond to beta blockers.
Relativity and the low energy nd Ay puzzle
Creators: name: Witala, H.
name: Golak, J.
name: Skibinski, R.
name: Glockle, W.
name: Polyzou, W. N.
name: Kamada, H.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We solve the Faddeev equation in an exactly Poincare invariant formulation of the three-nucleon problem. The dynamical input is a relativistic nucleon-nucleon interaction that is exactly on-shell equivalent to the high precision CDBonn NN interaction. S-matrix cluster properties dictate how the two-body dynamics is embedded in the three-nucleon mass operator. We find that for neutron laboratory energies above 20 MeV relativistic effects on Ay are negligible. For energies below 20 MeV dynamical effects lower the nucleon analyzing power maximum slightly by 2% and Wigner rotations lower it further up to 10 % increasing thus disagreement between data and theory. This indicates that three-nucleon forces must provide an even larger increase of the Ay maximum than expected up to now.
description: 29 pages, 2 ps figures
Correlation of microdistortions with misfit volumes in High Entropy Alloys
Creators: name: Nöhring, Wolfram Georg
name: Curtin, W. A.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The yield strengths of High Entropy Alloys have recently been correlated with measured picometer-scale atomic distortions. Here, the root mean square microdistortion in a multicomponent alloy is shown to be nearly proportional to the misfit-volume parameter that enters into a predictive model of solute strengthening. Analysis of two model ternary alloy families, face-centered cubic Cr-Fe-Ni and body-centered cubic Nb-Mo-V, demonstrates the correlation over a wide composition space. The reported correlation of yield strength with microdistortion is thus a consequence of the correlation between microdistortion and misfit parameter and the derived dependence of yield strength on the misfit parameter.
description: 12 pages, 3 figures
Subependymal Giant Cell Astrocytoma with good response to oral everolimus – a case report
Creators: name: Felix, Francisco
name: Albuquerque, Juliana
name: Juvenia Fontenele
Publisher: name: F1000Research
Year: 2015

description: The subependymal giant cell astrocytoma (SEGA) is a benign neoplasm of glioneuronal origin related to tuberous sclerosis (TS). It is a slow growth lesion that occurs commonly into the lateral ventricles near the foramen of Monro. Its growth can determine severe hydrocephalus. Surgery is curative when complete resection is possible. Up until recently, patients with progressive  disease and without surgical possibility had no effective alternative treatment (Goh, 2004; Krueger, 2010). The cellular signaling pathway that activates mammalian target of rapamycin (mTOR) is altered in many tumors. In TS, mutations in TSC protein 1 and 2 determine the loss of the ability to inhibit mTOR. Everolimus is an oral inhibitor of the mTOR pathway, that can inhibit tumor cell proliferation in patients with TS. A phase I / II clinical trial showed that everolimus induces SEGA regression in patients withTS (Easton, 2006 Krueger, 2010).

Methodology: retrospective analysis of medical records, with prior approval of the responsible for the patient. Figures of skin lesions and radiographic images were obtained by consent. The processing of nuclear magnetic resonance imaging (MRI) used the routines of the Osirix program for Mac OS X.

Case report: a little more than 2 years ago, the patient (5 years old) was diagnosed with a large lesion in the topography of the left lateral ventricle with the contralateral impairment due to the large volume. Surgical resection was carried out after about 18 months with removal of a small amount of the lesion. The patient was considered uneligible for further surgery and referred to the Pediatric Cancer Center, for evaluation. Imaging tests showed tumor progression (see infographic). Treatment was started with everolimus. The patient was heavily symptomatic and dependent of care without walking and interacting little. Everolimus was started at 1.5 mg/m2/day. After the serum demonstrated a concentration of 2.9 ng/ml the dose was increased to 3.0mg/m2/day. No side effects were observed and no laboratory test has changed. New imaging evaluation showed partial remission of the lesion. The patient showed a clear neurological improvement, managing to raise the trunk and neck, play and communicate more actively. In addition, her seizures, present from infancy, ceased and the patient was able to reduce its anti-epileptic medications from 4 to only 2 drugs.

The treatment of SEGA with everolimus has a quick and dramatic effect on these rare lesions and on the health of TS patients treated with this drug. Despite the current cost of medication and the possibility of the patient come to use it for the rest of his life, it becomes economically feasible to use it as first choice in the SEGA therapy in TS due to the great reduction in morbidity of patients.
Stochastic integration in UMD Banach spaces
Creators: name: van Neerven, J. M. A. M.
name: Veraar, M. C.
name: Weis, L.
Publisher: name: arXiv
Year: 2006
Subjects: subject: Probability (math.PR)
subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 60H05 (Primary); 28C20, 60B11 (Secondary)

description: In this paper we construct a theory of stochastic integration of processes with values in $\mathcal{L}(H,E)$, where $H$ is a separable Hilbert space and $E$ is a UMD Banach space (i.e., a space in which martingale differences are unconditional). The integrator is an $H$-cylindrical Brownian motion. Our approach is based on a two-sided $L^p$-decoupling inequality for UMD spaces due to Garling, which is combined with the theory of stochastic integration of $\mathcal{L}(H,E)$-valued functions introduced recently by two of the authors. We obtain various characterizations of the stochastic integral and prove versions of the Itô isometry, the Burkholder--Davis--Gundy inequalities, and the representation theorem for Brownian martingales.
description: Published at http://dx.doi.org/10.1214/009117906000001006 in the Annals of Probability (http://www.imstat.org/aop/) by the Institute of Mathematical Statistics (http://www.imstat.org)
Falcerminthus parvus LS
Creators: name: Bahoy, Daphne Cayle M.
name: Sabang, Aira Mae M.
name: Tan, Ming Kai
name: Nuñeza, Olga Macas
name: Robillard, Tony
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Orthoptera
Gryllidae
Falcerminthus
Falcerminthus parvus

description: Falcerminthus parvus (Baroga-Barbecho & Robillard, 2020)
(Figs 5A, 5B)
Lebinthus parvus Baroga-Barbecho et al., 2020: 419
Falcerminthus parvus —Tan et al., 2021: 1077 (new combination); Tan et al., 2023: 306 (description of calling song)
New material examined. PHILIPPINES: • 1♂; Mindanao, South Cotabato, Lake Sebu, Barangay Lamlakak, Allah Valley Protected Landscape, foot of the northern slope of Mt. Busa; N6.183858, E124.699522, 1062± 5 m.a.s.l.; 2 February 2024, 21h27; open area outside secondary forest, found on the leaf of a [juvenile] tree; leg. D.C. Bahoy & A. M. Sabang; LS60B; PNM • 1♂; same locality as L60B; N6.183939, E124.682933, 1064 m.a.s.l.; 2 February 2024, 21h36; open area outside secondary forest, near agricultural site, found on the leaf of Zea mays; leg. D.C. Bahoy & A. M. Sabang; LS63; PNM.
Remarks. New material collected at Lake Sebu in the south of Mindanao were identified as Falcerminthus parvus, thereby extending its distribution from the north to south of Mindanao.
Measurements. See Table 1.
Type locality. Philippines. Mindanao: Misamis Or. [Oriental], Mt. Balatukan, 15 km SW of Gingoog, 1000– 2000 m.
Distribution. Philippines: Misamis Oriental, Mt. Balatukan; Bukidnon, Mt. Kitanglad; Agusan, San Francisco; South Cotabato, Lake Sebu [new locality record] (Fig. 1B).
description: Published as part of Bahoy, Daphne Cayle M., Sabang, Aira Mae M., Tan, Ming Kai, Nuñeza, Olga Macas & Robillard, Tony, 2024, A new species and new records of the subtribe Lebinthina (Grylloidea, Eneopterinae, Lebinthini) from Mindanao, Philippines, pp. 167-178 in Zootaxa 5507 (1) on page 174, DOI: 10.11646/zootaxa.5507.1.8, http://zenodo.org/record/13747917
Additional file 1 of Confirmatory and bi-factor analysis of the Short Form Health Survey 8 (SF-8) scale structure in a German general population sample
Creators: name: Wirtz, M. A.
name: A. Schulz
name: E. Brähler
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Additional file 1. SF8_scoring_syntax.doc; SPSS syntax file for calculation the SF-8 scale scores.
Quantum Monte Carlo, Density Functional Theory, and Pair Potential Studies of Solid Neon
Creators: name: Drummond, N. D.
name: Needs, R. J.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We report quantum Monte Carlo (QMC), plane-wave density-functional theory (DFT), and interatomic pair-potential calculations of the zero-temperature equation of state (EOS) of solid neon. We find that the DFT EOS depends strongly on the choice of exchange-correlation functional, whereas the QMC EOS is extremely close to both the experimental EOS and the EOS obtained using the best semiempirical pair potential in the literature. This suggests that QMC is able to give an accurate treatment of van der Waals forces in real materials, unlike DFT. We calculate the QMC EOS up to very high densities, beyond the range of values for which experimental data are currently available. At high densities the QMC EOS is more accurate than the pair-potential EOS. We generate a different pair potential for neon by a direct evaluation of the QMC energy as a function of the separation of an isolated pair of neon atoms. The resulting pair potential reproduces the EOS more accurately than the equivalent potential generated using the coupled-cluster CCSD(T) method.
Testing MOND with Local Group spiral galaxies
Creators: name: Corbelli, Edvige
name: Salucci, Paolo
Publisher: name: arXiv
Year: 2006
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: The rotation curves and the relative mass distributions of the two nearby Local Group spiral galaxies, M31 and M33, show discrepancies with Modified Newtonian dynamic (MOND) predictions. In M33 the discrepancy lies in the kinematics of the outermost regions. It can be alleviated by adopting tilted ring models compatible with the 21-cm datacube but different from the one that best fits the data. In M31 MOND fails to fit the falling part of the rotation curve at intermediate radii, before the curve flattens out in the outermost regions. Newtonian dynamics in a framework of a stellar disc embedded in a dark halo can explain the complex rotation curve profiles of these two galaxies, while MOND has some difficulties. However, given the present uncertainties in the kinematics of these nearby galaxies, we cannot address the success or failure of MOND theory in a definite way. More sensitive and extended observations around the critical regions, suggested by MOND fits discussed in this paper, may lead to a definite conclusion.
description: 6 pages, 4 figures. To be published in MNRAS
Development of N-halamine Low-Melting Point Poly(ethylene terephthalate) Fibers via Melt Spinning: Structural Characterization and Demonstration of Rechargeable Antibacterial Properties
Creators: name: Rouhollah Ahmadi
name: Fashandi, Hossein
name: Vajihe Akbari
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Antibacterial low-melting-point poly(ethylene terephthalate) (LMP-PET) fibers are produced via melt spinning. First, LMP-PET granules are modified by free radical graft polymerization of acrylamide (AAm), an N-halamine precursor, using a twin-screw extruder to conduct reactive melt extrusion. The modified granules are spun into fibers using a melt spinning machine. The fibers are characterized by various analytical techniques. Potent rechargeable antibacterial properties of the fibers are assessed and demonstrated by zone of inhibition test, counting bacterial colonies, and imaging of dead bacteria. It is shown that increasing AAm concentration yields to enhanced rechargeable antibacterial properties while fibers structural properties are preserved.
Epithelial Expressed B7-H4 Drives Differential Immunotherapy Response in Murine and Human Breast Cancer
Creators: name: Gomez, Henry
name: Wescott, Elizabeth C.
name: Balko, Justin M.
name: Gallagher, Rosa I.
name: Santa-Maria, Cesar A.
name: Bronzini, Juliana
name: Esserman, Laura J.
name: Sanders, Melinda E.
name: van ˈt Veer, Laura J.
name: Gonzalez-Ericsson, Paula
name: Hanna, Ann
name: Isaacs, Claudine
name: Wilson, John T.
name: Sun, Xiaopeng
name: Pietenpol, Jennifer A.
name: Swigart, Lamorna Brown
name: Ballinger, Tarah J.
name: Taylor, Brandie C.
name: Hirst, Gillian L.
name: Shah, Payal D.
name: Lehmann, Brian D.
name: Petricoin, Emanuel F.
name: Dees, Elizabeth C.
name: Opalenik, Susan R.
name: Bharti, Vijaya
name: Wulfkuhle, Julia
name: Sanchez, Violeta
name: Abramson, Vandana G.
Publisher: name: American Association for Cancer Research (AACR)
Year: 2024

description: Combinations of immune checkpoint inhibitors (ICI, including anti-PD-1/PD-L1) and chemotherapy have been FDA approved for metastatic and early-stage triple-negative breast cancer (TNBC), but most patients do not benefit. B7-H4 is a B7 family ligand with proposed immunosuppressive functions being explored as a cancer immunotherapy target and may be associated with anti-PD-L1 resistance. However, little is known about its regulation and effect on immune cell function in breast cancers. We assessed murine and human breast cancer cells to identify regulation mechanisms of B7-H4 in vitro. We used an immunocompetent anti-PD-L1-sensitive orthotopic mammary cancer model and induced ectopic expression of B7-H4. We assessed therapy response and transcriptional changes at baseline and under treatment with anti-PD-L1. We observed B7-H4 was highly associated with epithelial cell status and transcription factors and found to be regulated by PI3K activity. EMT6 tumors with cell-surface B7-H4 expression were more resistant to immunotherapy. In addition, tumor-infiltrating immune cells had reduced immune activation signaling based on transcriptomic analysis. Paradoxically, in human breast cancer, B7-H4 expression was associated with survival benefit for patients with metastatic TNBC treated with carboplatin plus anti-PD-L1 and was associated with no change in response or survival for patients with early breast cancer receiving chemotherapy plus anti-PD-1. While B7-H4 induces tumor resistance to anti-PD-L1 in murine models, there are alternative mechanisms of signaling and function in human cancers. In addition, the strong correlation of B7-H4 to epithelial cell markers suggests a potential regulatory mechanism of B7-H4 independent of PD-L1.
SIGNIFICANCE: This translational study confirms the association of B7-H4 expression with a cold immune microenvironment in breast cancer and offers preclinical studies demonstrating a potential role for B7-H4 in suppressing response to checkpoint therapy. However, analysis of two clinical trials with checkpoint inhibitors in the early and metastatic settings argue against B7-H4 as being a mechanism of clinical resistance to checkpoints, with clear implications for its candidacy as a therapeutic target.
Propagation of UHE Protons through Magnetized Cosmic Web
Creators: name: Das, Santabrata
name: Kang, Hyesung
name: Ryu, Dongsu
name: Cho, Jungyeon
Publisher: name: arXiv
Year: 2008
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: If ultra-high-energy cosmic rays (UHECRs) originate from extragalactic sources, understanding the propagation of charged particles through the magnetized large scale structure (LSS) of the universe is crucial in the search for the astrophysical accelerators. Based on a novel model of the turbulence dynamo, we estimate the intergalactic magnetic fields (IGMFs) in cosmological simulations of the formation of the LSS. Under the premise that the sources of UHECRs are strongly associated with the LSS, we consider a model in which protons with E >10^{19} eV are injected by sources that represent active galactic nuclei located inside clusters of galaxies. With the model IGMFs, we then follow the trajectories of the protons, while taking into account the energy losses due to interactions with the cosmic background radiation. For observers located inside groups of galaxies like ours, about 70% and 35% of UHECR events above 60 EeV arrive within ~15 degree and ~5 degree, respectively, of the source position with time delays of less than ~10^7 yr. This implies that the arrival direction of super-GZK protons might exhibit a correlation with the distribution of cosmological sources on the sky. In this model, nearby sources (within 10 - 20 Mpc) should contribute significantly to the particle flux above ~10^{20} eV.
description: 24 pages, 8 figures, corrected typos
Multi-spike solutions of a hybrid reaction-transport model
Creators: name: Bressloff, Paul C
Publisher: name: arXiv
Year: 2020
Subjects: subject: Pattern Formation and Solitons (nlin.PS)
subject: Quantitative Methods (q-bio.QM)
subject: FOS: Physical sciences
subject: FOS: Biological sciences

description: Numerical simulations of classical pattern forming reaction-diffusion systems indicate that they often operate in the strongly nonlinear regime, with the final steady-state consisting of a spatially repeating pattern of localized spikes. In activator-inhibitor systems such as the two-component Gierer-Meinhardt (GM) model, one can consider the singular limit $D_a\ll D_h$, where $D_a$ and $D_h$ are the diffusivities of the activator and inhibitor, respectively. Asymptotic analysis can then be used to analyze the existence and linear stability of multi-spike solutions. In this paper, we analyze multi-spike solutions in a hybrid reaction-transport model, consisting of a slowly diffusing activator and an actively transported inhibitor that switches at a rate $α$ between right-moving and left-moving velocity states. This class of model was recently introduced to account for the formation and homeostatic regulation of synaptic puncta during larval development in {\em C. elegans}. We exploit the fact that that the hybrid model can be mapped onto the classical GM model in the fast switching limit $α\rightarrow \infty$, which allows us to establish the existence of multi-spike solutions. Linearization about the multi-spike solution leads to a non-local eigenvalue problem that is used to derive stability conditions for the multi-spike solution for finite $α$
description: 25 pages, 9 figures
Large energy storage efficiency of the dielectric layer of graphene nanocapacitors
Creators: name: Bezryadin, A.
name: Belkin, A.
name: Ilin, E.
name: Pak, M.
name: Colla, Eugene V.
name: Hubler, A.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Electric capacitors are commonly used in electronic circuits for short-term storage of small amounts of energy. It is desirable however to use capacitors to store much larger energy amounts to replace rechargeable batteries. Unfortunately, the existing capacitors cannot store a sufficient energy to be able to replace common electrochemical energy storage systems. Here we examine energy storage capabilities of graphene nanocapacitors, which are try-layers involving an Al film, Al2O3 dielectric layer, and a single layer of carbon atoms, i.e., graphene. This is a purely electronic capacitor and therefore it can function in a wide temperature interval. The capacitor shows a high dielectric breakdown electric field strength, of the order of 1000 kV/mm (i.e., 1GV/m), which is much larger than the table value of the Al2O3 dielectric strength. The corresponding energy density is 10 to 100 times larger than the energy density of a common electrolytic capacitor. Moreover, we discover that the amount of charge stored in the dielectric layer can be equal or can even exceed the amount of charge stored on the capacitor plates. The dielectric discharge current follows a power-law time dependence. We suggest a model to explain this behavior.
Οικογένεια και κοινωνικές σχέσεις των παιδιών στα σχολικά εγχειρίδια της γλώσσας του δημοτικού σχολείου:
Creators: name: Τσιλίκα, Ναταλία-Παρθενόπη Σωτηρίου
Publisher: name: Aristotle University of Thessaloniki
Year: 2009
Subjects: Σχολικά εγχειρίδια
Γλώσσα
Οικογένεια
Κοινωνικές σχέσεις
Δημοτικό Σχολείο
Παιδική φιλία
Family
School relations
Municipal school
Children's friendship
Books
Childhood

description: Σκοπός της εργασίας είναι η διερεύνηση της παρουσίασης της οικογένειας και των κοινωνικών σχέσεων των παιδιών σε όλα τα σχολικά εγχειρίδια της Γλώσσας του Δημοτικού Σχολείου με απώτερο στόχο να αποτυπωθεί η εικόνα που επικρατεί ως προς τα συγκεκριμένα κοινωνικά φαινόμενα. Έρευνα σε άρθρα επιστημονικών περιοδικών για την εκπαίδευση (1982 - 2007) φανέρωσε ότι η βιβλιογραφία σχετικά με τα σχολικά εγχειρίδια της Γλώσσας δεν είναι ολοκληρωμένη. Εν συνεχεία θεμελιώθηκαν οι έννοιες: παιδική ηλικία, παιδική φιλία και σχέσεις με συνομηλίκους, μορφές οικογενειακής οργάνωσης, πολυπολιτισμική εκπαίδευση.Με τη βοήθεια της ανάλυσης περιεχομένου εξετάστηκαν οι αντιλήψεις που προβάλλονται στα εγχειρίδια σε σχέση με τις τέσσερις παραπάνω κατηγορίες και καταλήξαμε σε ορισμένα συμπεράσματα.
description: Aim of work is the investigation of presentation of family and social relations of children in all the school handbooks of Language of Municipal School with final objective to impress the picture that prevails as for the particular social phenomena. Research in articles of scientific magazines on education (1982 - 2007) revealed that the bibliography about the school handbooks of Language is not completed.After that research we founded the significances: children's age, children's friendship and relations with other children, family, multicultural education. With analysis of content we examined the perceptions that appearred in the handbooks concerning the four categories and we led to certain conclusions.
Charm physics with highly improved staggered quarks
Creators: name: Davies, C. T. H.
name: Follana, E.
name: Hornbostel, K.
name: Lepage, G. P.
name: Mason, Q.
name: Trottier, H.
name: Shigemitsu, J.
name: Wong, K.
Publisher: name: arXiv
Year: 2006
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We use a relativistic highly improved staggered quark action to discretize charm quarks on the lattice. We calculate the masses and the dispersion relation for heavy-heavy and heavy-light meson states, and show that for lattice spacings below .1 fm, the discretization errors are at the few percent level. We also discuss the prospects for accurate calculations at the few percent level of f_D_s, f_D, and the leptonic width of the psi and phi.
description: 7 pages, contribution to Lattice 2006
Geometrical dependence in Casimir-Polder repulsion
Creators: name: Marchetta, John Joseph
name: Parashar, Prachi
name: Shajesh, K. V.
Publisher: name: arXiv
Year: 2020
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Repulsion, induced from quantum vacuum fluctuations, for an anisotropically polarizable atom on the symmetry axis of an anisotropically polarizable annular disc is studied. There exists two torsion free points on each side of the annular disc, where the interaction energy is orientation independent. The position of second of the two torsion free points, on either side of the disc, is shown to determine the orientation dependence of the atom at distances far from the plate, revealing a geometrical dependence. In the ring limit of the annular disc, new repulsion emerges.
description: 5 pages, 4 Figures, 1 Table
Cell-cycle inhibition and immune microenvironment in breast cancer treated with ribociclib and letrozole or chemotherapy
Creators: name: Gavilá, Joaquín
name: Gil-Gil, Miguel
name: Perou, Charles M.
name: Fernandez-Martinez, Aranzazu
name: Gonzàlez-Farré, Blanca
name: Villagrasa, Patricia
name: Gonzàlez-Farré, Xavier
name: Pascual, Tomás
name: Galván, Patricia
name: Brasó-Maristany, Fara
name: Ciruelos, Eva
name: Oliveira, Mafalda
name: Villacampa, Guillermo
name: Prat, Aleix
name: Agrawal, Yash
name: Saura, Cristina
name: Pfefferle, Adam D.
name: Hernando, Cristina
name: Chic, Nuria
name: Paré, Laia
name: Muñoz, Montserrat
Publisher: name: Springer Nature
Year: 2024

description: In this study, we performed genomic analyses of cell cycle and tumor microenvironment changes during and after ribociclib and letrozole or chemotherapy in the CORALLEEN trial. 106 women with untreated PAM50-defined Luminal B early breast cancers were randomly assigned to receive neoadjuvant ribociclib and letrozole or standard-of-care chemotherapy. Ki67 immunohistochemistry, tumor-infiltrating lymphocytes quantification, and RNA sequencing were obtained from tissue biopsies pre-treatment, on day 14 of treatment, and tumor specimens from surgical resection. Results showed that at surgery, Ki67 and the PAM50 proliferation scores were lower after ribociclib compared to chemotherapy. However, consistent reactivation of tumor cell proliferation from day 14 to surgery was only observed in the ribociclib arm. In tumors with complete cell cycle arrest (CCCA) at surgery, PAM50 proliferation scores were lower in the ribociclib arm compared to chemotherapy (p < 0.001), whereas the opposite was observed with tumor cellularity (p = 0.002). Gene expression signatures (GES) associated with antigen-presenting cells (APCs) and innate immune system activity showed increased expression post-chemotherapy but decreased expression post-ribociclib. Interferon-associated GES had decreased expression with CCCA and increased expression with non-CCCA. Our findings suggest that while both treatment strategies decreased proliferation, the depth and the patterns over time differed by treatment arm. Immunologically, ribociclib was associated with downregulated GES associated with APCs and the innate immune system in Luminal B tumors, contrary to existing preclinical data. Further studies are needed to understand the effect of CDK4/6 inhibition on the tumor cells and microenvironment, an effect which may vary according to tumor subtypes.
High resolution X-ray spectroscopy of Supergiant HMXB 4U1700$-$37 during the compact object eclipse
Creators: name: Martínez-Chicharro, M.
name: Grinberg, V.
name: Torrejón, J. M.
name: Schulz, N.
name: Oskinova, L.
name: Nowak, M.
name: Fürst, F.
name: Hell, N.
name: Hainich, R.
Publisher: name: arXiv
Year: 2020
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present an analysis of the first observation of the iconic High Mass X-ray Binary \so with the \chandra High Energy Transmission Gratings during an X-ray eclipse. The goal of the observation was to study the structure/physical conditions in the clumpy stellar wind through high resolution spectroscopy. We find that: a) emission line brightness from K shell transitions, corresponding to near neutral species, directly correlates with continuum illumination. However, these lines do not greatly diminish during eclipse. This is readily explained if fluorescence K$α$ emission comes from the bulk of the wind. b) The highly ionised Fexxv and Fexxvi Ly$α$ diminish during eclipse. Thus, they must be produced in the vicinity of the compact object where $\log ξ>3$. c) to describe the emission line spectrum, the sum of two self consistent photo ionisation models with low ionisation ($\log ξ\sim -1$) and high ionisation ($\log ξ\sim 2.4$) is required. From their emission measures, the clump-to-interclump density ratio can be estimated to be $n_c/n_i\sim 300$. To fit the complex He-like \ion{Si}{xiii}{} profile, the plasma requires a broadening with $v_{\rm bulk}\sim 840$ km s$^{-1}$. Reproducing the observed $r\approx f$ line fluxes requires the addition of a third collisionally ionised plasma. d) Emission lines widths appear unresolved at the \textsc{hetg} gratings resolution with exception of Silicon. There is no clear radial segregation between (quasi)neutral and ionised species, consistent with cold wind clumps interspersed in a hot rarefied interclump medium.
Artifact for Fast Deterministic Black-box Context-free Grammar Inference
Creators: name: Arefin, Mohammad Rifat
name: Shetiya, Suraj
name: Wang, Zili
name: Csallner, Christoph
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 461201
subject: Automated software engineering
classificationCode: 461204
subject: Programming languages

description: Artifact for "Fast Deterministic Black-box Context-free Grammar Inference", accepted at ICSE 2024 technical track.For detailed guidelines on how to use the artifact, please follow the instructions in the README file.
Quantum Monte Carlo study of the Ne atom and the Ne+ ion
Creators: name: Drummond, N. D.
name: Rios, P. Lopez
name: Ma, A.
name: Trail, J. R.
name: Spink, G.
name: Towler, M. D.
name: Needs, R. J.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We report all-electron and pseudopotential calculations of the ground-stateenergies of the neutral Ne atom and the Ne+ ion using the variational and diffusion quantum Monte Carlo (DMC) methods. We investigate different levels of Slater-Jastrow trial wave function: (i) using Hartree-Fock orbitals, (ii) using orbitals optimized within a Monte Carlo procedure in the presence of a Jastrow factor, and (iii) including backflow correlations in the wave function. Small reductions in the total energy are obtained by optimizing the orbitals, while more significant reductions are obtained by incorporating backflow correlations. We study the finite-time-step and fixed-node biases in the DMC energy and show that there is a strong tendency for these errors to cancel when the first ionization potential (IP) is calculated. DMC gives highly accurate values for the IP of Ne at all the levels of trial wave function that we have considered.
Absorbing states and elastic interfaces in random media: two equivalent descriptions of self-organized criticality
Creators: name: Bonachela, Juan A.
name: Chate, H.
name: Dornic, I.
name: Munoz, Miguel A.
Publisher: name: arXiv
Year: 2006
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We elucidate a long-standing puzzle about the non-equilibrium universality classes describing self-organized criticality in sandpile models. We show that depinning transitions of linear interfaces in random media and absorbing phase transitions (with a conserved non-diffusive field) are two equivalent languages to describe sandpile criticality. This is so despite the fact that local roughening properties can be radically different in the two pictures, as explained here. Experimental implications of our work as well as promising paths for future theoretical investigations are also discussed.
description: 4 pages. 2 Figures
title: Life Cycle Assessment of biochar, electricity, and heat from a wood gasification plant
Creators: name: Sistek, Maren
Publisher: name: FH Vorarlberg (Fachhochschule Vorarlberg)
Year: 2022
Subjects: subject: 600 Technik, Medizin, angewandte Wissenschaften

description: In recent years, numerous studies around the world have examined the environmental potential of biochar to determine whether it can help address climate challenges. Several of these studies have used the Life Cycle Assessment (LCA) method to evaluate the environmental impacts of biochar systems. However, studies focus mainly on biochar obtained from pyrolysis, while the number of studies on biochar from gasification is small. To contribute to the current state of LCA research on biochar from gasification, LCA was performed for biochar, electricity, and heat from a wood gasification plant in Vorarlberg, Austria. Woodchips from local woods are used as biomass feedstock to produce energy, i.e., electricity and heat. Thereby, biochar is obtained as a side product from gasification. The production of syngas and biochar takes place in a floating fixed-bed gasifier. Eventually, the syngas is converted to electricity in a gas engine and fed to the power grid. Throughout different stages within the gasification process, heat is obtained and fed into local heat grid to be delivered to customers. The biochar produced complies with the European Biochar Industry (EBI) guidelines and is used on a nearby farm for manure treatment and eventually for soil application. Thereby, the effect of biochar used for manure treatment is considered to reduce emissions occurring from manure, i.e., nitrogen monoxide (N2O). Further, the CO2 sequestration potential of biochar, i.e., removal of CO2 from the atmosphere and long-term storage, is considered. Several constructions, such as the construction of the gasification system and the heating grid, are included in the evaluation. As input related reference flow, 1 kg of woodchips with water content of 40 % is used. Three functionals units are eventually obtained, i.e., 0.17 kg of biochar applied to soil, 4.47 MJ of heat and 2.82 MJ of electricity, each per reference flow. The results for Global Warming Potential (GWP) for biochar is – 274.7*10 - 3 kg CO2eq per functional unit, which corresponds to – 1.6 kg CO2eq per 1 kg biochar applied to soil. The GWP for heat results in 17.1*10 - 3 CO2eq per functional unit, which corresponds to 3.6*10 - 3 kg CO2eq per 1 MJ. For electricity, a GWP of 38.1*10 - 3 kg CO2eq per functional unit is obtained, which is equivalent to 13.5*10 - 3 kg CO2eq per 1 MJ. The calculation was performed using SimaPro Version 9.1 and the ReCiPe method with hierarchist perspective.
van der Waals Interactions Between Thin Metallic Wires and Layers
Creators: name: Drummond, N. D.
name: Needs, R. J.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Quantum Monte Carlo (QMC) methods have been used to obtain accurate binding-energy data for pairs of parallel thin metallic wires and layers modeled by 1D and 2D homogeneous electron gases. We compare our QMC binding energies with results obtained within the random phase approximation, finding significant quantitative differences and disagreement over the asymptotic behavior for bilayers at low densities. We have calculated pair-correlation functions for metallic biwire and bilayer systems. Our QMC data could be used to investigate van der Waals energy functionals.
Η γλωσσική μεταρρύθμιση στην Τουρκία και τα αποτελέσματά της:
Creators: name: Παρασχάκη, Χρυσάνθη Γεωργίου
Publisher: name: Aristotle University of Thessaloniki
Year: 2008
Subjects: Γλώσσα και εθνικισμός
Τουρκική γλωσσική μεταρρύθμιση
θεωρία γλώσσα-ήλιος
Γλώσσα και μειονότητες
Language and nationalism
Turkish language reform
Sun language theory
Language and minorities

description: Σκοπός της παρούσας μεταπτυχιακής εργασίας είναι να παρακολουθήσει τα στάδια της Γλωσσικής Μεταρρύθμισης στην Τουρκία και να εκτιμήσει τα αποτελέσματά της. Σε πρώτη φάση, εξετάζεται η σχέση της γλώσσας με τον εθνικισμό. Έπειτα, μετά από μία σύντομη αναδρομή στην ιστορία της Τουρκικής γλώσσας, γίνεται λόγος για τις εξελίξεις του γλωσσικού ζητήματος κατά τον 19ο και στις αρχές του 20ου αιώνα, με τους διανοούμενους να επισημαίνουν την ανάγκη για αλλαγή και απλοποίηση στη γλώσσα. Εκτενής αναφορά γίνεται στη Γλωσσική Μεταρρύθμιση που έλαβε χώρα μεταξύ 1928-1938: η αλλαγή της γραφής (1928-1930), η περίοδος του ‘εξαγνισμού’ της γλώσσας (1932-1936) και η Θεωρία Γλώσσα-Ήλιος (1936-1938). Στη συνέχεια, εξετάζονται οι γλωσσικές πολιτικές, ιδιαίτερα οι γλωσσικές απαγορεύσεις που εφαρμόστηκαν την ίδια περίοδο, σε σχέση με τον αντίκτυπο που είχαν στις αλλόγλωσσες μειονότητες της Τουρκίας. Τα μετέπειτα χρόνια, επικεντρωνόμαστε στο πώς οι πολιτικές εξελίξεις στη σύγχρονη Τουρκία επηρέασαν την πορεία της Γλωσσικής Μεταρρύθμισης μέχρι σήμερα και πού έχει ασκηθεί κριτική για τις πρακτικές του παρελθόντος.
description: The aim of this master’s thesis is to follow the steps of the Language Reform in Turkey and to evaluate its results. At first, we examine the relationship of language and nationalism. Then, after making a brief reference to the history of Turkish language we talk about the developments in the language issue during 19th and early 20th centuries, when the intellectuals stress the need for change and simplification in language. We refer in length to the Language Reform which took place in 1928-1938: the change of the script (1928-1930), the period of ‘purification’ in language (1932-1936) and the Sun-Language Theory (1936-1938). Following, we examine the language policies, especially the language prohibitions which took place during the same period, in relation to their impact on the non-Turkish speaking minorities of Turkey. Finally, we concentrate on the impact of the political developments in modern Turkey on the course of the Language Reform until today and on the points of criticism for language policy implementations of the past.