cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Cytochrome P4501A Induction by Highly Purified Hexachlorobenzene in Primary Cultures of Avian Hepatocytes
Creators: name: Mundy, Lukas
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: Hexachlorobenzene
organic pollutants
fungicide
HCB

description: Hexachlorobenzene (HCB) is a persistent organic pollutant that was primarily produced for use as a fungicide dating back to the 1940s. Worldwide emissions have declined steadily over the past forty years, but HCB is still produced as a by-product of a number of industrial processes and is still detected in remote locations around the globe. Many studies have been conducted to determine the toxic and biochemical effects of HCB, but it has been suggested that reported toxic and biochemical effects initially attributed to HCB exposure may have actually been elicited by contamination of HCB by polychlororinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (PCBs). This thesis investigates whether highly purified HCB (HCB-P; defined as HCB containing < 0.2 ppb of any PCDD, PCDF, or co-planar PCB congener [the detection limit of current analytical methods]) can induce cytochrome P4501A (CYP1A) in three avian species in vitro. Primary cultures of chicken (Gallus gallus domesticus), ring-necked pheasant (Phasianus colchicus) and Japanese quail (Corturnix japonica) embryo hepatocytes were used to compare the potencies of reagent-grade (RG-HCB), HCB-P and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as inducers of ethoxyresorufin O-deethylase (EROD) activity, CYP1A4 messenger ribonucleic acid (mRNA) and CYP1A5 mRNA. The potencies of two mono-ortho substituted PCBs, 2,3,3’,4,4’-pentachlorobiphenyl (PCB 105) and 2,3’,4,4’,5-pentachlorobiphenyl (PCB 118) were also assessed in chicken embryo hepatocytes using the same endpoints. All compounds induced EROD activity and up-regulated CYP1A4/5 mRNAs in the hepatocytes of each species. The potency of HCB relative to the potency of TCDD (ReP) was 0.0001, 0.001 and 0.01 in chicken, ring-necked pheasant and Japanese quail embryo hepatocytes, respectively. ECthreshold values were suggested to be more appropriate than EC50 values because ECthreshold values account for differences in maximal EROD and CYP1A4/5 mRNA levels that are observed with HCB exposure in avian embryo hepatocytes more so than EC50 values. Differences in species sensitivity to HCB were also assessed, and did not vary as greatly as the listed ReP values. The results presented herein suggest that HCB is capable of inducing effects downstream of activation of the aryl hydrocarbon receptor, and may warrant its inclusion in the World Health Organization’s toxic equivalency concept.
Glycobiology studies of Influenza-A and SARS-CoV-2 respiratory viruses: the use of glycans as receptors and the role of host cells in viral protein glycosylation
Creators: name: Hassard, Jack
Publisher: name: Imperial College London
Year: 2024

description: Glycosylation plays a significant role in the life cycle of many viruses: from providing a receptor to assisting in the folding of viral proteins, as well as shielding these proteins from the host’s immune system. In the case of influenza A viruses, their surface glycoproteins haemagglutinin (HA) and neuraminidase bind to glycans expressing sialic acid (Sia). In general, human IAVs prefer a2- 6 linked Sia, however, there are reports that H3N2 viruses are more selective in their HA receptor preference: H3N2 viruses have evolved a preference for bi-antennary glycans containing extended poly-LacNAc chains terminating in a2-6 linked Sia. This shift in receptor preference has led to challenges propagating and characterising modern H3N2 viruses in the laboratory. Here we demonstrate that targeting specific enzymes involved in glycosylation pathways can produce extended glycan receptors in HEK cells, demonstrating the potential of this approach to be applied to other cell lines. Glycans have also been reported to act as secondary receptors enhancing infection of the novel respiratory virus SARS-CoV-2. Multiple studies have highlighted the potential for heparan sulfate (HS) to enhance SARS-CoV-2 cell entry. The mechanism by which SARS- CoV-2 Spike binds to HS is poorly understood despite HS having been demonstrated to enhance SARS-CoV-2 infection in vitro. We confirm that SARS-CoV-2 may utilize HS as a potential secondary receptor and that both the receptor binding domain and N-terminal domain of the Spike protein are likely to contribute to HS binding. Finally, SARS-CoV-2 Spike itself is heavily glycosylated, however, there is variance among the glycosylation profiles published to date, which provides increasing evidence that the expression system used influences the glycosylation present on the Spike protein. We have assessed the effect of using different expression systems to express SARS-CoV-2 spike and find significant differences between glycosylation profiles depending on the expression system used.
Metacognitive Aspects of Face Identification
Creators: name: Watier, Nicholas
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: Face Identification
Metacognition
Distinctiveness

description: To date, relatively little research has investigated participants’ ability to monitor their memory for faces and names. Four experiments were conducted with aim of developing a comprehensive profile of memory monitoring performance during face identification tasks. In each experiment, memory monitoring judgements were solicited during encoding and/or retrieval of unfamiliar face-name pairs. In general, subjective estimates of future and past memory performance were valid predictors of objective memory performance, regardless of whether a face or name was the item to be retrieved from memory. As a test of the stability of memory monitoring accuracy across different categories of stimuli, memory monitoring for face-name pairs was compared with noun-noun pairs. The predictive validity of estimates of future memory performance was similar across the categories of stimuli, but the predictive validity of estimates of past memory performance was superior for nouns compared with names. A subset of the studies examined the influence of face and name distinctiveness on memory and memory monitoring for face-name associations. This was done in an attempt to identify sources of information that individuals might use to monitor their memory during face-name learning. The beneficial effects of distinctiveness on associative memory were symmetrical between faces and names, such that relative to their typical counterparts, distinct faces enhanced memory for names, and distinct names enhanced memory for faces. These effects were also apparent in memory monitoring. Estimates of future and past memory performance were greater for face-name associations that contained a distinct face or name compared with a typical face or name, regardless of whether the distinct item was a cue or target. Moreover, the predictive validity of prospective monitoring improved with name distinctiveness, whereas the predictive validity of retrospective monitoring improved with facial distinctiveness. Altogether, the results of the dissertation indicate that participants can monitor their memory for faces and names at a level above chance, that retrospective metamemory is more accurate for nouns compared with names, and that distinctiveness not only affects the strength of the association between a face and a name, but also the ability to monitor that association.
Supplementary document for Detecting momentum weak value: Shack–Hartmann versus weak measurement wavefront sensor - 5370310.pdf
Creators: name: Zheng, Yi
name: Yang, Mu
name: Liu, Zheng-Hao
name: Xu, Jin-Shi
name: Li, Chuanfeng
name: Guo, Guang-can
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: A derivation of an equation and technical details of weak measurement wavefront sensor
Polarization Dependent Femtosecond Laser Microstructuring of Silicon
Creators: name: Al-Khazraji, Hajar
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: Polarization
Femtosecond
Microstructuring
Silicon

description: Microstructuring of silicon is performed to alter its optical and electrical properties for use in photonic devices. Femtosecond lasers are a favourable structuring tool because they are extremely precise due to the confinement of their interaction to the focal volume. Experiments were carried out on N-type, P-type, and intrinsic silicon with a femtosecond laser operating at 800 nm, with pulse duration of 40 fs, and 1 kHz repetition rate. A single pulse produced a micro-ring structure surrounding a crater. It is caused by the motion of material according to the pressure gradient induced by the Gaussian profile of the laser. Multiple-pulse structures were similar to the single pulse except for the central protrusion of material. Two factors are responsible for multiple-pulse structures: (1) geometrical difference of the plasma compared to the single pulse (2) reflections of shockwaves produce protruding structures. Polarization dependence of all structures was observed.
title: Московские корреспонденты академика Е. Ф. Карского
Creators: name: Шишкина, К. Г.
Publisher: name: Реноме
Year: 2018

description: Статья посвящена переписке академика Евфимия Федоровича Карского (1860–1931) с московскими корреспондентами. Среди них известный собиратель и исследователь древнерусской письменности Е. В. Барсов и московские профессора — В. Ф. Миллер, П. А. Расторгуев и Г. А. Ильинский. Основная часть переписки хранится в СПбФ АРАН и охватывает период 1896–1931 гг. Дан краткий обзор писем и выделены основные темы. Переписка ученых носит не только деловой характер, но и содержит сведения биографического характера и является важным источником информации по изучению истории науки и образования на рубеже XIX–XX вв.

Ключевые слова: академик Е. Ф. Карский, Е. В. Барсов, В. Ф. Миллер, П. А. Расторгуев, Г. А. Ильинский, корреспонденция ученых, СПбФ АРАН.
Möglichkeiten einer ressourcenschonenden Kreislaufwirtschaft durch weitergehende Gewinnung von Rohstoffen aus festen Verbrennungsrückständen aus der Behandlung von Siedlungsabfällen
Creators: name: Quicker, Peter
name: Stockschläder, Jan
name: Zayat-Vogel, Battogtokh
Publisher: name: My University
Year: 2018
Subjects: subject: Asche
subject: Metall
subject: Siedlungsabfallverbrennung
subject: Nassentauschung
subject: Trockentauschung
subject: Nassenschlackung
subject: Trockenentschlackung
subject: Rostasche
subject: Rostschlacke
subject: mechanische Aufbereitungsverfahren
subject: Metallrückgewinnung
subject: Bio-leaching
subject: Bioflotation
subject: Flokkulation
subject: Abfall | Ressourcen

description: Ziel des vorliegenden Berichts war es, die beiden Optionen – der trockenen Entaschung/-schlackung und Nassentaschung/-schlackung im Wasserbad – hinsichtlich der Qualität der ausgelesenen Metalle und Mineralik experimentell zu untersuchen. Dazu wurden Aschen/Schlacken aus einer Abfallverbrennungsanlage nass und trocken ausgetragen und anschließend anhand aufbereitungstechnischer, metallurgischer sowie bautechnischer Charakterisierungsmethoden bewertet. Neben der klassischen Aufbereitung, wie beispielsweise Magnetscheidung, wurden im Labormaßstab neue Ansätze wie biologische und chemische Laugung sowie Bioflotation zur Metallrückgewinnung aus der Feinfraktion < 4 mm untersucht.
title: Клинико-эпидемиологическая характеристика хронических миелопролиферативных заболеваний в Республике Саха (Якутия)
Creators: name: Александрова, Т. Н.
name: Павлова, Н. И.
name: Куртанов, Х. А.
name: Мулина, И. И.
name: Ядрихинская, В. Н.
name: Соловьева, И. Е.
name: Терехова, Л. Д.
name: Санникова, А. Н.
name: Парфенова, С. Н.
name: Попова, А. М.
name: Костина, В. Ф.
name: Федорова, М. А.
Publisher: name: Реноме
Year: 2018

description: Тромботические осложнения наблюдаются у пациентов с ХМПЗ в 34,6% случаев. В большинстве случаев тромбозы являются первым клиническим симптомом миелопролиферативного заболевания, что определяет необходимость внедрения в клиническую практику методов молекулярно-генетического тестирования среди пациентов с тромбозами, повышением уровней форменных эле-ментов крови, спленомегалией для ранней диагностики клонального гемопоэза и назначения таргетного препарата.
Design of integral motor and its embedded system
Creators: name: Motamed Ektesabi, Mehran
Publisher: name: Swinburne
Year: 2024

description: Migration from traditional motors to more intelligent motors may be seen as a new motor manufacturing trend. It may be considered as addition of intelligence to the motors, so that the overall package requires no more space, yet is capable of increase in efficiency and working capabilities. In this paper an integral motor with a unique design is proposed to overcome critical issues associated with the motor and its embedded systems. It proposes a compact unit built to operate in arduous industrial environments with optimized power consumption and best practice motor management under different load conditions. Advantages of the proposed Integral motor are compactness of combo motor and drive system with no external cabling/wiring. This motor provides a perfect shielding for least amount of radiated emission. It has an inbuilt filter for EMC compliance and has been designed to provide lower EMC noise for immunity of the internal electronics as well as other neighboring systems.
Goal-oriented Pattern Family Framework for Business Process Modeling
Creators: name: Ahmadi Behnam, Saeed
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2012
Subjects: goal model
business process model
pattern
pattern family
requirements engineering
knowledge reusability
goal oriented pattern
family framework
CoPF

description: While several approaches exist for modeling goals and business processes in organizations, the relationships between these two views are often not well defined. This inhibits the effective reuse of available knowledge in models. This thesis aims to address this issue through the introduction of a Goal-oriented Pattern Family (GoPF) framework that helps constructing business process models from organization goals while expanding these goals, establishing traceability relationships between the goal and process views, and improving reusability. Methods for extracting domain knowledge as patterns, which are composed of goal model building blocks, process model building blocks, and their relationships, and for maintaining the patterns over time are also presented. The GoPF framework provides the infrastructure for defining pattern families, i.e., collections of related patterns for particular domains. The foundation of GoPF is formalized as a profile of the User Requirements Notation, a standard modeling language that supports goals, scenarios, and links between them. A method for the use of GoPF is defined and then illustrated through a case study that targets the improvement of patient safety in healthcare organizations. The framework and the extraction/maintenance methods are also validated against another case study involving aviation security in a regulatory environment. The GoPF framework is expected to have a positive impact on the scientific community through the formalization, evolution, and reuse of patterns in domain-specific business domains. From an industrial viewpoint, this framework will also help intermediary organizations (such as consulting firms) who are required to repeatedly create and document goal and process models for other organizations in their business domain.
3D Visualization of Heterogeneous User Interactions in a Social Network
Creators: name: Pei, Wanjun
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015

description: With the popularity of social networks, users can communicate with each other in a more convenient way. However, the increasing amount of data poses new challenges for the analysis of the social activities of the users. In this article, we propose to visualize the heterogeneous information of user interactions in a social network in a three-dimensional way using the concept of solar systems. The target user represents the center of the solar system. We determine physical variables from interaction frequencies between the user and their friends to be visualized. This gives the user a better insight about their relationships on Facebook. To show the interactions between the user and their friends, we choose four variables related to the solar system: the size of each planet, its angular velocity, and the semi-major and the semi-minor axis of its elliptical orbit. Our system measures the interaction frequencies between a user and their friends based on a linear model. Its coefficients are derived from an online survey we performed. The experimental results indicate that the accuracy of our estimated interaction frequency is better than the accuracy for each individual interaction feature. The average accuracy improvement is 15.93%.
Real-time Interrogation of Fiber Bragg Grating Sensors Based on Chirped Pulse Compression
Creators: name: Liu, Weilin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: chirped microwave pulse
cross-correlation
dispersion
dispersive Fourier transformation
fiber Bragg grating
Wavelength-to-time mapping

description: Theoretical and experimental studies of real-time interrogation of fiber Bragg grating (FBG) sensors based on chirped pulse compression with increased interrogation resolution and signal-to-noise ratio are presented. Two interrogation systems are proposed in this thesis. In the first interrogation system, a linearly chirped FBG (LCFBG) is employed as the sensing element. By incorporating the LCFBG in an optical interferometer as the sensor encoding system, employing wavelength-to-time mapping and chirped pulse compression technique, the correlation of output microwave waveform with a chirped reference waveform would provide an interrogation result with high speed and high resolution. The proposed system can provide an interrogation resolution as high as 0.25 μ at a speed of 48.6 MHz. The second interrogation system is designed to achieve simultaneous measurement of strain and temperature. In this system, a high-birefringence LCFBG (Hi-Bi LCFBG) is employed as a sensing element.
Carpe Noctem: Social Media and the Sharing of the Night Skies
Creators: name: Vasseur, Michael F.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: Social Media
Communication
Motivation
Astrocasting
Self-Determination Theory
Thesis
Leisure
Serious Leisure Perspective
Mallincam
Night Skies Network

description: The emergence of astrocasting on the Internet offered an opportunity to study the creation of a Social Media site, and determine the influence of the participants’ perception of this leisure activity and their motivation for it. The Night Skies Network was examined under a Social Media theoretical framework. The motivation for astrocasting was studied using the Self-Determination Theory of Motivation, and its perception as a leisure activity using the Serious Leisure Perspective. The methodology used included a focus group that provided a qualitative perspective, and an on-line questionnaire using the Serious Leisure Inventory and Measure and the Leisure Motivation Scale for quantitative data. The results showed that the Night Skies Network did meet the requirements for a Social Media site, that the participants considered astrocasting as a serious leisure activity, and that they were intrinsically motivated towards it, with a strong emphasis on the Intrinsic Motivation to Know.
50 Two-Transistor MOSFET Circuits: A tribute to the versatility of MOSFETs
Creators: name: Pretl, Harald
name: Eberlein, Matthias
Publisher: name: Zenodo
Year: 2022
Subjects: MOST
MOSFET
metal-oxide-semiconductor transistors
circuits

description: We present a summary talk of our compendium paper of two-metal-oxide-semiconductor (MOS)-transistor circuits, which span the range from simple standard configurations to ingenious arrangements, and are a testament to the versatility of the MOSFET. Using these building blocks, circuit designers can assemble a vast array of complex analog functions. This (incomplete) collection shall serve as a reference and inspiration to junior circuit designers, and hopefully contains at least one unexpected example for professional engineers.
Supplementary document for Expansion tomography for large volume tissues imaging with nanoscale resolution - 5370561.pdf
Creators: name: Chen, Ruixi
name: Cheng, Xiaofeng
name: Zhang, Yongsheng
name: Yang, Xiong
name: Wang, Yu
name: Liu, Xiuli
name: Zeng, Shaoqun
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Neuroscience

description: Supplemental Document
Intra-Cycle Elastic Nonlinearity of Nitrogen-Doped Carbon Nanotube/Polymer Nanocomposites under Medium Amplitude Oscillatory Shear (MAOS) Flow
Creators: name: Kamkar, Milad
name: Sadeghi, Soheil
name: Arjmand, Mohammad
name: Aliabadian, Ehsan
name: Sundararaj, Uttandaraman
Publisher: name: Multidisciplinary Digital Publishing Institute
Year: 2020

description: This study seeks to unravel the effect of carbon nanotube’s physical and chemical features on the final electrical and rheological properties of polymer nanocomposites thereof. Nitrogen-doped carbon nanotubes (N-CNTs) were synthesized over two different types of catalysts, i.e., Fe and Ni, employing chemical vapor deposition. Utilizing this technique, we were able to synthesize N-CNTs with significantly different structures. As a result, remarkable differences in the network structure of the nanotubes were observed upon mixing the N-CNTs in a polyvinylidene fluoride (PVDF) matrix, which, in turn, led to drastically different electrical and rheological properties. For instance, no enhancement in the electrical conductivity of poorly-dispersed (N-CNT)Ni/PVDF samples was observed even at high nanotube concentrations, whereas (N-CNT)Fe/PVDF nanocomposites exhibited an insulative behavior at 1.0 wt%, a semi-conductive behavior at 2.0 wt%, and a conductive behavior at 2.7 wt%. In terms of rheology, the most substantial differences in the viscoelastic behavior of the systems were distinguishable in the medium amplitude oscillatory shear (MAOS) region. The stress decomposition method combined with the evaluation of the elastic and viscous third-order Chebyshev coefficients revealed a strong intra-cycle elastic nonlinearity in the MAOS region for the poorly-dispersed systems in small frequencies; however, the well-dispersed systems showed no intra-cycle nonlinearity in the MAOS region. It was shown that the MAOS elastic nonlinearity of poorly-dispersed systems stems from the confinement of N-CNT domains between the rheometer’s plates for small gap sizes comparable with the size of the agglomerates. Moreover, the intra-cycle elastic nonlinearity of poorly-dispersed systems is frequency-dependent and vanished at higher frequencies. The correlation between the microstructure and viscoelastic properties under large shear deformations provides further guidance for the fabrication of high-performance 3D-printed electrically conductive nanocomposites with precisely controllable final properties for engineering applications.
The Journey Towards Professional Competence: A Case Study of the Reflective Process of Six Japanese EFL Teachers During a Professional Development Programme in Canada
Creators: name: Lundy, Marlene
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011

description: Many researchers claim that reflective practice is an integral component of professional development and a necessary component for the development of professional competence, which involves both dispositional competencies (knowledge or awareness of) and capacity competencies (the skills and attitudes required to make reasoned judgments about professional practice). The lack of such reflective practice has been identified as an underlying reason why many teachers have difficulty applying formal learning in their classrooms post-training. This qualitative research study examined the impact of introducing a reflective process into a 2007 Canadian teacher education programme for six Japanese secondary English as a foreign language teachers (EFL). It was hypothesized that introducing a reflective process around a contextually-based research project (also known as the Professional Development Dossier or PDD) would be instrumental in helping to bridge the theory practice gap so common in similar programmes. Data sources included reflective worksheets, classroom observation records, practice teaching summaries, research essays, and one-on-one pre and post-training programme interviews. The results of this case study analysis indicate that the PDD research process was instrumental in developing the teachers’ knowledge of required second language teaching methodologies such as Communicative Language Teaching and raised their awareness of the important role teachers plays in creating a classroom environment that is conducive to learning (dispositional competencies). However, it was the reflective process supporting the research process that assisted the teachers in understanding how to apply this knowledge in their individual teaching contexts. The reflective process promoted the development of reasoned judgments regarding the teaching theories, activities, and teaching practices best suited to their specific teaching challenges. This experience provided the Japanese English teachers with the skills needed to create a more balanced English language programme for their Japanese students (capacity competencies). The findings from this study suggest that teacher education programmes which include a contextually based research project that is supported by critical reflection, classroom observation, mentoring, and practice teaching can be instrumental in helping to bridge the theory-practice gap. This study also suggests that a longitudinal approach to research is needed to more clearly understand the interaction between teacher education and teaching context.
Méthode de la lecture, lecture de la méthode : l'acte de lecture en didactique de la traduction (Canada)
Creators: name: Normandin, Julie Stéphanie
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: Théories de la lecture (champ littéraire)
Théorie interprétative
Théorie fonctionnaliste du Skopos
Didactique de la traduction (Canada)

description: Cette étude entend questionner l’impensé de la lecture et de la textualité sous-jacent aux modèles traductologiques orientés vers le processus qui se sont imposés en didactique de la traduction au cours des quatre dernières décennies, tels que la théorie interprétative de l’École de Paris et la théorie fonctionnaliste du Skopos de l’École allemande, et qui sous-tendent actuellement la formation des traducteurs professionnels au Canada. On trouvera dans ces pages, après un survol de l’histoire de cette formation, une confrontation dialogique entre les fondements immanentistes des approches qui y sont dominantes et ceux de théories issues du champ littéraire ayant problématisé l’acte de lecture, ainsi que l’analyse de la traduction collective d’une œuvre de fiction (réalisée par une équipe de traducteurs diplômés du premier cycle) dont le but est d’étayer la critique métathéorique.
Sortilin is a Negative Regulator of Sonic Hedgehog Processing and Anterograde Trafficking in Neurons
Creators: name: Campbell, Charles
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2016
Subjects: Sonic Hedgehog
Sortilin1
Anterograde Trafficking
Protein Processing
Neuron

description: Sonic Hedgehog (SHH) is a secreted morphogen that is an essential regulator of patterning and growth. The SHH protein requires cleavage of its full-length precursor (SHHFL) for secretion of biologically active SHH (SHHNp). Mutations in SHH that affect SHH processing are associated with human disease, which highlights the importance of processing for patterning in vivo. We identified Sortilin (SORT1), a member of the VPS10P receptor family, as a novel SHH interacting protein. SORT1 preferentially associates with SHHFL and SORT1 levels correlate inversely with cleavage of SHHFL. Consistent with an antagonistic relationship between SORT1 and SHH processing, loss of SORT1 results in an increase in SHH levels in axons and a partial rescue of Hedgehog-associated patterning defects in a mouse model of deficient SHH processing. Finally, we demonstrate a functional requirement for SORT1-mediated trafficking on SHH-dependent signaling from axons in the developing visual system in vivo. Our findings identify a novel role for SORT1 in the regulation of SHH processing and trafficking.
A Study of Early Sixteenth-Century English Music Fragments from the DIAMM Database
Creators: name: Hamilton, Elizabeth P.K.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2011
Subjects: DIAMM
music
manuscript
sixteenth-century
sixteenth century
england
fragment
mensural
functional
performance practice
scribe
scribal practice
period use
musica ficta
Digital Image Archive of Medieval Music
secular
sacred
liturgical
court
concordance
stemmatics
accidentals

description: While the study of complete sources is very valuable, and has contributed greatly to what is understood of music history, the perspective they contribute is limited because they cannot reveal information about how music and music sources were most often used. The study of functional sources, more probably created for use, allows for more insight into how music was performed and understood, and how such sources were created, used and valued. This study examines twelve fragmentary early sixteenth-century English sources from the Digital Image Archive of Medieval Music (DIAMM) database, constituting a sample of functional music sources in this period. The study of this sampling reveals information about how functional manuscripts were created, used and valued in England during this time period. Some of the fragments contain works with concordances. These concordances are compared using variant comparison, where differences in the versions of the work are considered and weighed. The comparative study of concordances provides insight into the transmission of the versions, scribal and performance culture, as well as into music culture in general. Overall, the study of this sampling of early sixteenth-century functional English sources provides a clearer understanding of the use of accidentals, scribes and scribal culture, performers, performance practice and music culture in England at this time, contributing to the understanding of music history.
Calliscirpus Gen. Nov. and its Relationships Within the Hyperdiverse Cariceae + Dulichieae + Scirpeae Clade (Cyperaceae)
Creators: name: Gilmour, Claire N.
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2013
Subjects: Cyperaceaee
Calliscirpus
Cariceae + Dulichieae + Scirpeae clade

description: Eriophorum crinigerum (Scirpeae, Cyperaceae) has been placed in either the genus Scirpus (club-rushes) or Eriophorum (cottograsses), but a unique combination of bristle and inflorescence features suggests that it could represent a new generic lineage. In addition, prior field studies and initial analyses suggested that E. crinigerum could consist of two species. Using molecular, morphological, anatomical, embryological and geographical data, I examine relationships within the hyperdiverse Cariceae + Dulichieae + Scirpeae clade (ca. 2055 species)to which E. crinigerum belongs and I explore whether this species could contain undocumented species diversity. Results demonstrate not only that E. crinigerum represents a new genus within Cyperaceae, here called Calliscirpus, but it can be divided into two allopatric species, C. criniger and C. brachythrix sp. nov. Calliscirpus brachythrix is confined to the Sierra Nevada Mountains and C. criniger is confined to the Klamath-Siskiyou and North Coastal Mountains; all three mountain ranges are found within the California Floristic Province (USA) which is well known for its high generic and species endemism. My results suggest that Calliscirpus is distantly related to Eriophorum, but that it could be most closely related to the Cariceae, a osmopolitan clade representing almost 40% of all Cyperaceae diversity.
School crisis management in the 21st century: an examination of school counsellors' preparedness and implications for training
Creators: name: Trethowan, Vicki
Publisher: name: Swinburne
Year: 2024

description: This thesis investigated the range of critical incidents impacting on Australian schools, the type of training accessed by school counsellors and implications for school crisis management training in the Australian state of Victoria. The study had two general aims. The first was to identify Victorian school counsellors' level of crisis management training, and associated training needs. The second aim was to develop a comprehensive crisis management model which was specific to schools. One hundred and twenty school counsellors working in Victorian government schools completed a questionnaire that gathered data regarding demographic information, experiences in school crisis work, crisis management training accessed, school satisfaction with crisis responses, self care practices and crisis management training needs. Results showed that the majority of school counsellors had been required to respond to critical incidents involving death, suicide, sexual assaults and/or motor vehicle accidents. Counsellors reported that schools called on them for support and that most schools were very satisfied with the support they received, but the school counsellors indicated that they see the need to know more about school crisis management. Results also indicated that few of the school counsellors sampled had accessed pre-service crisis management training. A large portion had engaged in some in-service crisis management training. Results further indicated that theoretical model/clear procedures, current research, intervention skills, practice scenarios and school staff training were considered by school counsellors important aspects of school crisis management training needs. Based on the study findings, a new comprehensive crisis management model that could guide school crisis management practices and crisis management training for school counsellors was developed. Methodological considerations and recommendations for future research were discussed.
Folic acid supplementation in children with sickle cell disease: study protocol for a double-blind randomized cross-over trial
Creators: name: Williams, Brock A.
name: McCartney, Heather
name: Adams, Erin
name: Devlin, Angela M.
name: Singer, Joel
name: Vercauteren, Suzanne
name: Wu, John K.
name: Karakochuk, Crystal D.
Publisher: name: BioMed Central
Year: 2020

description: Background: Sickle cell disease (SCD) is a genetic disorder which causes dysfunctional red blood cells (RBC) and is thought to increase requirements for folate, an essential B vitamin, due to increased RBC production and turnover in the disease. High-dose supplementation with 1–5 mg/d folic acid, synthetic folate, has been the standard recommendation for children with SCD. There is concern about whether children with SCD need such high doses of folic acid, following mandatory folic acid fortification of enriched grains in Canada, and advancements in medical therapies which extend the average lifespan of RBCs. In animal and human studies, high folic acid intakes (1 mg/d) have been associated with accelerated growth of some cancers, and the biological effects of circulating unmetabolized folic acid (UMFA), which can occur with doses of folic acid ≥ 0.2 mg/d, are not fully understood. The objective of this study is to determine efficacy of, and alterations in folate metabolism from high-dose folic acid in children with SCD during periods of folic acid supplementation versus no supplementation. Methods: In this double-blind randomized controlled cross-over trial, children with SCD (n = 36, aged 2–19 years) will be randomized to either receive 1 mg/d folic acid, the current standard of care, or a placebo for 12 weeks. After a 12-week washout period, treatments will be reversed. Total folate concentrations (serum and RBC), different folate forms (including UMFA), folate-related metabolites, and clinical outcomes will be measured at baseline and after treatment periods. The sum of the values measured in the two periods will be calculated for each subject and compared across the two sequence groups by means of a test for independent samples for the primary (RBC folate concentrations) and secondary (UMFA) outcomes. Dietary intake will be measured at the beginning of each study period. Discussion: As the first rigorously designed clinical trial in children with SCD, this trial will inform and assess current clinical practice, with the ultimate goal of improving nutritional status of children with SCD. Trial registration: ClinicalTrials.gov NCT04011345 . Registered on July 8, 2019
Analysis of MicroRNAs in Biological Samples
Creators: name: Khan, Nasrin
Publisher: name: Université d'Ottawa / University of Ottawa
Year: 2015
Subjects: MicroRNA
Capillary Electrophoresis
Laser induced fluorescence detection
Circulating miRNA
Post-transcriptional modification
Mass Spectrometry

description: MicroRNAs (miRNAs) are a class of small, single-stranded, non-protein coding RNA molecules that regulate cellular messenger RNA (mRNA) and protein levels by binding to specific mRNAs. Aberrant miRNA expression has been shown to be implicated in several diseases, including cancer. Extracellular miRNAs have been found to circulate in the bloodstream and some of their levels have been associated with different diseases. Furthermore, they hold promise as tissue- and blood-based biomarkers for cancer classification and prognostication. Blood-based biomarkers are attractive for cancer screening due to their minimal invasiveness, relatively low cost and ease of reproducibility. New miRNA analysis techniques will add toward the understanding of their biological functions. In this thesis, I investigate the utility of capillary electrophoresis (CE) and mass spectrometry (MS) for analysis of miRNAs through proof-of-concept experiments. In the fi rst part of this work, we developed a Protein-Facilitated Affinity Capillary Electrophoresis (ProFACE) assay for rapid quantification of miRNA levels in blood serum (see List of publications (6)). We also implemented a capillary electrophoresis with laser induced fluorescence detection (CE-LIF) method with online sample pre-concentration for detection of endogenous microRNAs in human serum and cancer cells. 3' modification of miRNA is a physiological and common post-transcriptional event that shows selectivity for specific miRNAs and is observed across species. Recent studies have shown that post-transcriptional addition of nucleotides to the 3' end of miRNAs is a mechanism for miRNA activity regulation. For example, such modifications in plants and C. elegans influence miRNA stability. In humans, effects on miRNA stability and on mRNA target repression have both been observed. Thus, there is a need for miRNA detection techniques which are direct and multiplexed, require minimal sample preparation and provide qualitative information regarding these modifications. We developed a multiplexed miRNA detection technique based on capillary electrophoresis coupled on line with electrospray ionization mass spectrometry (CE-ESI-MS). This method allowed a label-free, direct detection of multiple miRNAs extracted from cancer serum as well as their post-transcriptional modifications with a high mass accuracy.
Gehaltsspannen von organischem Kohlenstoff in Ackerböden
Creators: name: Marx, Marc
name: Gaul, Viktoria
Publisher: name: My University
Year: 2021

description: Humus bzw. organischer Kohlenstoff (Corg) in Böden erfüllt zahlreiche Funktionen: er dient beispielsweise als Nährstoff-, Wasser- sowie Kohlenstoffspeicher und trägt zum Erosionsschutz bei. Der Erhalt und - dort, wo es möglich ist - die Erhöhung des Humusgehaltes ist eine gesamtgesellschaftliche Aufgabe. Im § 17 Bundes-Bodenschutzgesetz (BBodSchG) wird gefordert, dass "der standorttypische Humusgehalt des Bodens, [â€¦] erhalten wird" ohne konkrete Werte zu nennen. In diesem Artikel wird eine Methode für die Ableitung von standorttypischen Gehaltsspannen von organischem Kohlenstoff vorgeschlagen und die daraus resultierenden deutschlandweiten Werte basierend auf den Daten der Boden-Dauerbeobachtung präsentiert. Darüber hinaus werden weitere Differenzierungen dieser Gehaltsspannen zur regionalen Anwendung angeregt. Die Gehaltsspannen und vor allem die Ableitungsmethode sollten von allen relevanten Akteuren aus Bodenschutz, Wissenschaft und Landwirtschaft diskutiert werden, um den § 17 BBodSchG (Gute fachliche Praxis in der Landwirtschaft) mit Werten zu untersetzen. © 2021 Erich Schmidt Verlag GmbH & Co. KG
description: Humus or organic carbon (Corg), respectively, in soils fulfils numerous functions: for example, it stores nutrients, water as well as carbon and contributes to protection against erosion. Maintaining and - where possible - increasing the humus content is a task for society as a whole. Article 17 of the Federal Soil Protection Act (Bundes-Bodenschutzgesetz, BBodSchG) requires that "the soil's humus content, as is typical for the site in question, shall be conserved [â€¦]" with out giving concrete values. In this article, a derivation method for site-specific ranges of soil organic carbon is proposed and the resulting Germany-wide values based on long-term soil monitoring data are presented. In addition, further differentiations of these ranges are proposed for regional application. The ranges and especially the derivation method should be discussed by all relevant actors from soil protection, science and agriculture in order to underpin Article 17 BBodSchG (Good Agricultural Practice) with values. © 2021 Erich Schmidt Verlag GmbH & Co. KG
Incorporating security requirements into communication protocols in multi-agent software systems
Creators: name: Luo, Yuxiu
name: Antoniou, Giannakis
name: Sterling, Leon
Publisher: name: Swinburne
Year: 2024

description: A communication protocol is a fundamental component of a multi-agent system. The security requirements for a communication protocol should be articulated during the early stages of software development. However, there is no formal way provided for software developers to find out what makes a communication protocol secure and what are secure designs. In this paper we propose a method that defines security requirements, bridges security requirement analysis with security design, and integrates the security techniques into a communication protocol to fulfill the security requirements.
Supplementary document for Raman enhancement mechanism and experiments of cavity-enhanced AgNPs decorated tapered fiber sensor - 5371262.pdf
Creators: name: Wang, Zhengkun
name: Yu, Zhinan
name: Wang, Ning
name: Zhu, Yong
name: Zhang, Jie
Publisher: name: Optica Publishing Group
Year: 2025
Subjects: Uncategorized

description: Experimental setup, background subtraction, and Eqs. (S1) and (S2)
Study of transport of fluids under nano-confinement using non-equilibrium molecular simulation
Creators: name: Xu, Weilun
Publisher: name: Imperial College London
Year: 2024

description: The boundary-driven non-equilibrium molecular dynamics (BD-NEMD) has been introduced to evaluate the mass transport coefficients of fluids in nano-confinement. In contrast to the traditional equilibrium simulation route, BD-NEMD directly measures flux and thermodynamic gradients between upstream and downstream of a porous media, which leads to accurate transport parameters while demanding less computational cost. In this work, the use of BD-NEMD on nano-confined fluids are investigated and extended to binary fluids. A novel technique that evaluates steady-state adsorbed densities at pore entry/exit using adsorption isotherms is proposed. By comparing with the traditional EMD method, it is shown that BD-NEMD is robust and suitable for the study of the transport of dense fluids in nano-confinement. BD-NEMD is further used to investigate the effect of the geometry and morphology of porous solids on the transport of nano-confined fluids. It is demonstrated that the fully mutualized plug-like flow and fast transport which is commonly observed in slit pores do not present itself in rugose pores. Depending on the choice of pore model, transport diffusivity is observed to drop up to two orders of magnitudes; It is also observed that pore selectivity varies with rugosity level, which greatly alters the adsorption/transport of multi-component fluids. The different solid models used in this work are generalised using pore characteristic parameters. It is demonstrated that the transport coefficients are correlated to these parameters. This work has a direct impact on the understanding and modelling of unconventional hydrocarbon recovery and flow in organic shale rocks.
Berichterstattung unter der Klimarahmenkonvention der Vereinten Nationen und dem Kyoto-Protokoll 2019
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2019
Subjects: subject: Klimarahmenkonvention
subject: Treibhausgasinventar
subject: Treibhausgasemission
subject: UNFCCC
subject: Entwicklung der Treibhausgasemissionen
subject: Treibhausgasausstoß
subject: Klima | Energie

description: Als Vertragsstaat der Klimarahmenkonvention der Vereinten Nationen (UNFCCC) ist Deutschland seit 1994 dazu verpflichtet, Inventare zu nationalen Treibhausgasemissionen zu erstellen, zu veröffentlichen und regelmäßig fortzuschreiben. Gemäß Entscheidung 24/CP.19 müssen alle im ANNEX I der Klimarahmenkonvention aufgeführten Staaten jährlich einen Nationalen Inventarbericht (NIR) erstellen und übermitteln, der detaillierte und vollständige Angaben über den gesamten Prozess der Erstellung der Treibhausgasinventare bereitstellt. Durch diesen Bericht soll die Transparenz, Konsistenz und Vergleichbarkeit der Inventare sichergestellt und der unabhängige Überprüfungsprozess unterstützt werden. Quelle: Bericht
description: Als Vertragsstaat der Klimarahmenkonvention der Vereinten Nationen (⁠UNFCCC⁠) ist Deutschland seit 1994 dazu verpflichtet, Inventare zu nationalen Treibhausgasemissionen zu erstellen, zu veröffentlichen und regelmäßig fortzuschreiben. Gemäß Entscheidung 24/CP.19 müssen alle im ANNEX I der Klimarahmenkonvention aufgeführten Staaten jährlich einen Nationalen Inventarbericht (NIR) erstellen und übermitteln, der detaillierte und vollständige Angaben über den gesamten Prozess der Erstellung der Treibhausgasinventare bereitstellt. Durch diesen Bericht soll die Transparenz, Konsistenz und Vergleichbarkeit der Inventare sichergestellt und der unabhängige Überprüfungsprozess unterstützt werden.
Role play in 3D virtual environments
Creators: name: Wyeld, Theodor G.
Publisher: name: Swinburne
Year: 2024

description: Researchers are beginning to explore the role of digital design collaboration within multi-user 3D virtual environments. In the latest installment of an ongoing remote digital design collaboration project with the Sydney University Key Centre of Design Computing and Cognition (KCDC), the University of Queensland Information Environments Program (IEP) co-coordinated an online production of T. S. Eliot's The Cocktail Party in a 3D virtual world environment. This paper describes the process and pedagogical outcomes of early learners collaborating remotely in digital 3D media.