cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Additional file 2: Figure S2. of α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism
Creators: name: Yun, Seung
name: Donghoon Kim
name: Sangjune Kim
name: SangMin Kim
name: Senthilkumar Karuppagounder
name: Seung-Hwan Kwon
name: Saebom Lee
name: Tae-In Kam
name: Suhyun Lee
name: Sangwoo Ham
name: Park, Jae
name: Valina Dawson
name: Dawson, Ted
name: Yunjong Lee
name: Ko, Han
Publisher: name: figshare
Year: 2018
Subjects: subject: Neuroscience
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: 111714 Mental Health
subject: FOS: Health sciences

description: The schematic diagram depicts the time schedule of intervention and analyses performed. Numerals represent the days experiments were conducted. On 1th day we injected saline or MPTP (2 h interval, 4 times, 20 mg/kg free base) in 8 months WT, GBA +/L444P , SNCA−/−, GBA +/L444P SNCA−/− mice. On 6th day, the pole and grip strength were performed. On 7th day, mice were sacrificed for indicated studies. Following are animal numbers used for these studies: behavioral (n = 10), neurochemical (n = 5), immunohistochemistry (n = 5), and biochemical studies (n = 4) per each treatment group. (PDF 110 kb)
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Cart. 188 (11 H 73), f. 0117v
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Archives départementales de la Côte-d'Or, Cart. 188 (11 H 73), f. 0117v, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Archives départementales de la Côte-d'Or, Cart. 188 (11 H 73), f. 0117v, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
Type Annotation for Adaptive Systems
Creators: name: Bottoni, Paolo
name: Fish, Andrew
name: Presicce, Francesco Parisi
Publisher: name: arXiv
Year: 2016
Subjects: subject: Software Engineering (cs.SE)
subject: Programming Languages (cs.PL)
subject: FOS: Computer and information sciences
subject: F.3.2;D.2.2;D.2.10

description: We introduce type annotations as a flexible typing mechanism for graph systems and discuss their advantages with respect to classical typing based on graph morphisms. In this approach the type system is incorporated with the graph and elements can adapt to changes in context by changing their type annotations. We discuss some case studies in which this mechanism is relevant.
description: In Proceedings GaM 2016, arXiv:1612.01053
General Finnish DMP guidance
Creators: name: Tuuli-Project
Publisher: name: Zenodo
Year: 2018

description: National guidance and questions that assist with data management planning have been updated in 2018. A large group of experts co-operated in writing the guidance. The members of the group came from Finnish universities, research institutions and The Academy of Finland. The work was coordinated by Tuuli office, which is funded (2015-2018) by Ministry in Education and Culture. The questions and guidance have been modified based on user feedback to make them more explicit and easier to understand. The questions and guidance will be updated annually in the future as well. As the expertise of the users increases it would be useful that the structure of the guidance stays the same. The guidance is in English, Finnish and Swedish.
Additional file 1: of Comparison of two different coagulation algorithms on the use of allogenic blood products and coagulation factors in severely injured trauma patients: a retrospective, multicentre, observational study
Creators: name: Kaserer, Alexander
name: Casutt, Mattias
name: Sprengel, Kai
name: Seifert, Burkhardt
name: Spahn, Donat
name: Stein, Philipp
Publisher: name: figshare
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Science Policy
subject: Hematology

description: Transfusion and coagulation algorithm of the Cantonal Hospital Lucerne (LUKS-Alg). (PDF 23Â kb)
Gli smart workers tra solitudine e collaborazione
Creators: name: Albano, Roberto
name: Parisi, Tania
name: Tirabeni, Lia
Publisher: name: Cambio. Rivista sulle Trasformazioni Sociali
Year: 2019

description: This essay focuses on the risk of solitude of smart workers, i.e. those people who perform mobile, remotely and digitally intensive relations of work. Reduction in face-to-face interactions with organizational members can have negative effects on either their professional identity and sense of community, or their extra-work life. On the other side, a growing number of mobile workers is discovering novel social spaces and collective practices (e.g. Coworking Centers, Fab Labs). On the basis of a review of theoretical and research literature, and the analysis of data from the European Working Condition Survey, we connect the interpretation of smart working and of new digitalized practices of collaborative work. Is smart working a win win solution for organizations and workers or merely a new form of intensification of work? Do the new practices of collaborative work overcome the risk of isolation posed by the remote work? Or are they perfectly complementary to smart working to reduce labor costs and share human capital? As empirical evidence does not permit to formulate clear answers to these questions, we try to identify trend lines for some future scenarios in terms of risks and opportunities.
description: Cambio. Rivista sulle Trasformazioni Sociali, Vol 9 No 17 (2019): Political Solitude
Characterization of complete mitochondrial genome of Periclimenes brevicarpalis (Decapoda: Palaemonidae)
Creators: name: Peng, Chao
name: Fan, Sigang
name: Peng, PengFei
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Virology

description: Periclimenes brevicarpalis is widely distributed in the Indo West Pacific oceans. The mitochondrial genome of P. brevicarpalis was sequenced and assembled firstly by next generation sequencing technology in our study. The complete mitochondrial genome of P. brevicarpalis was 16,673 bp in size, consisted of 22 transfer RNA genes, 13 protein coding genes and two ribosomal RNA genes. The contents of the four bases were C (25.62%), T (28.73%), A (31.64%), and G (14.01%). The result of phylogenetic analysis showed that P. brevicarpaliswas clustered with Anchistus australis. In conclusion, our research provided valuable data for phylogenetic analysis of the Palaemonidae family as the first report about mitochondrial genomes in Periclimenes.
Breeding and foraging ecology of the threatened Gould's petrel, Pterodroma leucoptera
Creators: name: Kim, Yuna
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Many seabirds experience threats in their environment when breeding and foraging in the highly variable marine ecosystems. Understanding breeding and foraging ecology is crucial to conserve threatened species. The research presented in this thesis aimed to investigate the foraging ecology of Gould's Petrel (Pterodroma leucoptera) on Cabbage Tree Island (CTI), New South Wales (NSW), Australia, to provide a knowledge base to inform the future conservation and management of this threatened species. First, I validated my methods to ensure they were ethical and effective. I found no detectable negative impact of using tracking devices on adult mass changes and associated chick growth and breeding success. Second, I tested the reliability and practicality of four techniques (trapping adults, measuring mass change in chicks, examining images from infrared cameras and analysing temperature data from geolocators) to monitor nest attendance rates. I concluded that temperature loggers featured within geolocators could be used to monitor nest attendance effectively. Third, I explored the relationships between body mass, incubation shift duration and nest desertion and concluded that incubation success was limited by the condition of birds at the start of the shift and their tenacity to remain until relieved by their partner. Lastly, but most importantly, I identified the core foraging areas of Gould's Petrels during the breeding season, which were previously unknown. In addition, I confirmed that Gould's Petrels adopted a dual foraging strategy by measuring foraging trip durations and distances during the breeding season. Examination of regurgitated stomach contents suggested diversity and variation in diet of the Gould's Petrel, showing that it is an opportunistic forager, which is important to cope with variable environment. These findings are discussed in relation to management of issues with a view to improving conservation strategies for this threatened species and, potentially, other small pelagic seabirds.
title: ADCO, Cinquième cartulaire de Saint-Étienne de Dijon (1664), Cart. 28 (G 132), 258 folios, f. 00470
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
name: Petot, Frédéric
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Cinquième cartulaire de Saint-Étienne de Dijon (1664), Archives départementales de la Côte-d'Or, Cart. 28 (G 132), 258 folios, f. 00470, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cinquième cartulaire de Saint-Étienne de Dijon (1664), Archives départementales de la Côte-d'Or, Cart. 28 (G 132), 258 folios, f. 00470, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
The Solitude of Power. A Reflection on the Political
Creators: name: Grimaldi, Giorgio
Publisher: name: Cambio. Rivista sulle Trasformazioni Sociali
Year: 2019

description: In 1954 Carl Schmitt writes a dialogue entitled Dialogue on Power and on Access to the Powerful, in which he notices and examines the solitude of those who hold and exert power. He describes a twine of power, in which on one hand those who have command are in a state of dependence, and on the other hand those who should only represent the intermediate passage between the vertex (individual or assembly) and the basis (the people) are raised to a decision élite. This twine of power reflects, in a sort of variant, the master/servant dialectics of the Hegelian Phenomenology of Spirit, in which, at the end of the dialectics, the two extremes of the relationship overturn. This dialectics actually dissolves domination, that is, the power exerted through the relation of master/servant, every time, differently varied. Instead, Schmitt thinks of power only as domination. Hence, we have to distinguish power from domination. Via this crucial distinction it will be possible to aptly think and practice democracy.
description: Cambio. Rivista sulle Trasformazioni Sociali, Vol 9 No 17 (2019): Political Solitude
השפעת מיקוד שליטה והצלחת אחרים על מסוגלות עצמית אקדמית
Creators: name: Hadar Sagiv
name: TAU Experimental Psychology Team
name: Peled, Maya
name: GAL YAGIL
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: זוהי הרשמה מראש למחקר במסגרת קורס פסיכולוגיה ניסויית
Characterization of the VVV Survey RR Lyrae Population across the Southern Galactic Plane
Creators: name: Minniti, Dante
name: Dékány, Istvan
name: Majaess, Daniel
name: Palma, Tali
name: Pullen, Joyce
name: Rejkuba, Marina
name: Alonso-García, Javier
name: Catelan, Marcio
name: Ramos, Rodrigo Contreras
name: Gonzalez, Oscar A.
name: Hempel, Maren
name: Irwin, Mike
name: Lucas, Philip W.
name: Saito, Roberto K.
name: Tissera, Patricia
name: Valenti, Elena
name: Zoccali, Manuela
Publisher: name: arXiv
Year: 2017
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Deep near-IR images from the VISTA Variables in the Vía Láctea (VVV) Survey were used to search for RR Lyrae stars in the Southern Galactic plane. A sizable sample of 404 RR Lyrae of type ab stars was identified across a thin slice of the 4$^{\rm th}$ Galactic quadrant ($295°< l < 350°$, $-2.24°< b < -1.05°$). The sample's distance distribution exhibits a maximum density that occurs at the bulge tangent point, which implies that this primarily Oosterhoff type I population of RRab stars does not trace the bar delineated by their red clump counterparts. The bulge RR Lyrae population does not extend beyond $l \sim340 °$, and the sample's spatial distribution presents evidence of density enhancements and substructure that warrants further investigation. Indeed, the sample may be employed to evaluate Galactic evolution models, and is particularly lucrative since half of the discovered RR Lyrae are within reach of Gaia astrometric observations.
description: 10 pages, 13 figures. AJ, in press
La solitudine come tecnica di dominio.
Creators: name: Gallino, Francesco
Publisher: name: Cambio. Rivista sulle Trasformazioni Sociali
Year: 2019

description: This work aims to understand solitude and isolation as a domination tool, as it was conceptualized and experimented in early XIX century prison reforms. Focus will be placed on French political thinker Alexis de Tocqueville’s critical reception of the French and Anglophone prison debates as well as on its field study of U.S. penitentiaries. As both a theorist and a political reformer, Tocqueville can be regarded as a key source concerning the philosophical path underlying the invention and early development of penitentiary systems. Tocqueville particularly stressed the importance of adopting convicts isolation as an essential step in order to accomplish a radical renewal of French prisons. His writings can therefore contribute to frame XIX century theorists’ understanding of «solitary confinement» and deprivation of mutual communication, as well as to analyze the different perspectives which distinguished the promoters of the various (and competing) forms of penitentiary solitude. Tocqueville’s writings on prisons, in turn, will be read through the interpretation of political thinker Roger Boesche, who interestingly evoked Tocqueville’s studies on solitude in prisons in order to draw a critique of late XX century consumerism.
description: Cambio. Rivista sulle Trasformazioni Sociali, Vol 9 No 17 (2019): Political Solitude
Additional file 4: Appendix B. of Pregnancy outcomes in women taking probiotics or prebiotics: a systematic review and meta-analysis
Creators: name: Jarde, Alexander
name: Anne-Mary Lewis-Mikhael
name: Moayyedi, Paul
name: Stearns, Jennifer
name: Collins, Stephen
name: Beyene, Joseph
name: McDonald, Sarah
Publisher: name: figshare
Year: 2018
Subjects: subject: Medicine
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Inorganic Chemistry
subject: Science Policy
subject: Hematology

description: Individual study data.docx; Individual study data; Individual study data for all outcomes, comparisons and analyses. (DOCX 1588 kb)
EBL Inhomogeneity and Hard-Spectrum Gamma-Ray Sources
Creators: name: Abdalla, Hassan
name: Boettcher, Markus
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: The unexpectedly hard very-high-energy (VHE; $E > 100$ GeV) $γ$-ray spectra of a few distant blazars have been interpreted as evidence for a reduction of the $γγ$ opacity of the Universe due to the interaction of VHE $γ$-rays with the extragalactic background light (EBL) compared to the expectation from our current knowledge of the density and cosmological evolution of the EBL. One of the suggested solutions to this problem consisted of the inhomogeneity of the EBL. In this paper, we study the effects of such inhomogeneities on the energy density of the EBL (which then also becomes anisotropic) and the resulting $γγ$ opacity. Specifically, we investigate the effects of cosmic voids along the line of sight to a distant blazar. We find that the effect of such voids on the $γγ$ opacity, for any realistic void size, is only of the order of $\lesssim 1$ % and much smaller than expected from a simple linear scaling of the $γγ$ opacity with the line-of-sight galaxy under-density due to a cosmic void.
description: Accepted for Publication in The Astrophysical Journal
An investigation of the treatment journey of paediatric patients with acute lymphoblastic leukaemia in hospital
Creators: name: Nhiwatiwa, Dudzayi Caxton
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: Background and aims: Leukaemia is the most prevalent childhood cancer, with acute lymphoblastic leukaemia (ALL) the most common sub-type. ALL cure rate is high, however, the treatment journey is long and complex. There has been limited research quantifying or describing the types and causes of delays experienced by ALL patients. This study aimed to summarise the characteristics of ALL patients; identify key milestones of the ALL treatment journey; and identify when and why delays occurred. Methods: Site: The Oncology Department of a paediatric tertiary hospital in Sydney.Sample: All patients diagnosed with ALL during a one-year period (January 10th 2013 to January 10th 2014) and treated using the Study 9 Protocol.Procedure: Data on: demographics; treatment delays and causes; and supportive care for patients were extracted via an in-depth retrospective audit of clinical information systems as well as review of the treatment protocol and discussions with key oncology clinicians at the hospital. Results: The average delays experienced during the two-year treatment journey were 33 days and 94 days for standard risk/medium risk and high risk patients respectively. Nearly 90% of treatment delays were due to low counts, other toxicities or a combination of these factors. Nine percent and 1% of the delays were attributed to organisational factors and patient factors respectively. Despite these delays, most patients completed all milestones of ALL treatment. Conclusions: The ALL patient journey is often interrupted by treatment delays, mostly due to treatment-related toxicity, but also due to patient factors and organisational issues. The use of electronic health records systems may potentially reduce delays due to organisational issues by improving care coordination.
Double loneliness and double belonging.
Creators: name: Pasini, Cecilia
Publisher: name: Cambio. Rivista sulle Trasformazioni Sociali
Year: 2019

description: In experiencing migration, some actors may take political action to contrast their own loneliness and to claim the belonging both to the host country and the country of origin. For the foreigners living in Italy, approaching to the social and political struggles of the community of origin can be a way to claim the belonging to a group, or to several groups. The objective of this contribution is to analyse the transnational networks of the political mobilisation at the time of globalization, the migration flows and the increasing use of online social networks. The Moroccan movement Hirak Rif was born in the region of Rif during October 2016 to advance social, political and economic demands. This work’s aim is to examine the mobilisation of the Moroccans living in Italy, in particular of those from the Riffian region. They use Facebook as a tool of struggle, to fight the loneliness that they consider the end of the Hirak’s strength. In this contribution, the role of the social networks as means of separation among individuals is questioned, supporting instead their unifying function. The social networks as political tools are essential to the existence of the Moroccan diaspora’s political action. This comes clear both from the observation of the movement’s action and from the interviews with the activists. Therefore, the assumption of the movement’s loneliness and the methods used in order to oppose it, seem to be strategies to fight the loneliness of the activists themselves. This can be seen as a migrant’s double loneliness, echoing the migrant’s double absence of Sayad’s analysis . The activists’ actions put in place to support the Riffian movement would lead, on the one hand, to the strengthening of the links between the individuals and the group of origin; on the other hand, they would lead to the creation or to the consolidation of the group in the immigration country. The political action, made possible and easier thanks to the social networks, is used by the activists to create and legitimate both groups. In this way the double political belonging of the activists is built and strengthened.
description: Cambio. Rivista sulle Trasformazioni Sociali, Vol 9 No 17 (2019): Political Solitude
Additional file 9 of Comprehensive analysis of complete chloroplast genome and phylogenetic aspects of ten Ficus species
Creators: name: Huang, Yuying
name: Li, Jing
name: Yang, Zerui
name: An, Wenli
name: Xie, Chunzhu
name: Liu, Shanshan
name: Zheng, Xiasheng
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 9: Table S8. The 23 studied species and the corresponding chloroplast whole genome GenBank accession number.
Whole chloroplast genome sequence and phylogenetic analysis of Calanthe discolor (Orchidaceae)
Creators: name: Liu, Qiuping
name: Song, Qin
name: Yu, Yan
name: Shi, Yiming
name: Lu, Minghui
name: Chen, Yan
name: Tan, Leitao
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Plant Biology

description: The orchid Calanthe discolor, which has high ornamental and medicinal value, is mainly distributed in Zhejiang, Jiangsu, and southeast Hubei Provinces of China, as well as in Japan and the southern Korean peninsula. In this study, the whole chloroplast genome sequence of C. discolor was first assembled using high-throughput Illumina paired-end technology, providing data to evaluate the evolution of this species. The C. discolor chloroplast genome was158,286 bp long, including a large single-copy region of 87,095 bp, a small single-copy region of 18,407 bp, and two copies of a repeat region (26,392-bp each). The overall G + C content was 41.2%. A total of 133 genes were predicted from the genome, including 87 protein-coding genes, eight ribosomal RNAs, 38 transfer RNAs. Phylogenetic analysis indicated a close relationship between C. discolor and C. bicolor.
Dynamics of 3-Forms in Seven Dimensions
Creators: name: Krasnov, Kirill
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: We continue to study a certain dynamical theory of 3-forms in seven dimensions, which can be viewed as a non-linear 7D analog of the 3D Abelian Chern-Simons theory. We perform the 6+1 split and show that the theory propagates 3 degrees of freedom. We also study the dimensional reduction on S3. We find the resulting theory to be a variant of 4D scalar-tensor theory of gravity.
description: 25 pages, no figures
Ricerca attivismo e trasformazione sociale nel post sisma
Creators: name: Olori, Davide
name: Menghi, Marta
Publisher: name: Cambio. Rivista sulle Trasformazioni Sociali
Year: 2019

description: In December 2016 the research project on the post-earthquake of the Central Apennines and the research group Emidio of Treviri was born. It generated a collective and self-organized research experience, oriented to a militant approach, which for over two years studies and returns the various aspects of the post-earthquake. This experience showed both the potential of this kind of research practice, based on a continuous interaction with the subjects involved in the post-disaster processes, and its implicit limits. Our proposal starts from empirical research, yet with the aim of providing theoretical evaluations on the emancipatory potential of a critical social science, systematizing its risks and opportunities, as we have faced them during our field experience. The paper focuses in particular on the issues of the internal organization of the group, the organizational balance between efficiency and self-management, the methodologies and research techniques employed in relation to the pursued aims (methodological level); on the relationship with political and academic structures, in terms of opportunities and risks, sustainability and planning of the activity (epistemological level); on the transformative power of field-research, i.e. the ability to influence social processes (political level). The aim of the work is the critical analysis of a public (Buroway, 2007) and collective research process with the ultimate intent of relaunching its innovative scope in the processes of social change and its central role in the production, accumulation and sharing of knowledge.
description: Cambio. Rivista sulle Trasformazioni Sociali, Vol 9 No 17 (2019): Political Solitude
Additional file 1: Figure S1. of α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism
Creators: name: Yun, Seung
name: Donghoon Kim
name: Sangjune Kim
name: SangMin Kim
name: Senthilkumar Karuppagounder
name: Seung-Hwan Kwon
name: Saebom Lee
name: Tae-In Kam
name: Suhyun Lee
name: Sangwoo Ham
name: Park, Jae
name: Valina Dawson
name: Dawson, Ted
name: Yunjong Lee
name: Ko, Han
Publisher: name: figshare
Year: 2018
Subjects: subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Molecular Biology
subject: Pharmacology
subject: Science Policy
subject: Plant Biology

description: Activity of 20S proteasome was measured in WT and GBA +/L444P primary cultured neurons (n = three per each group). Student’s t-test was used to for statistical analysis. *P
title: The effects of supergrids and superblocks on the transformation of the historic urban fabric of Kashan city in Iran
Creators: name: Karbalaei Hassani, Elham
Publisher: name: Conference Proceedings XXIX International Seminar on Urban Form ISUF 2022 Urban Redevelopment and Revitalisation A Multidisciplinary Perspective/Lodz University of Technology Press
Year: 2023
Subjects: uperblock, Supergrid, Urban Morphology, Kashan City, Historic Urban Context.

description: Building a broad network of wide and long routes in the center of ancient cities inspired the most significant modernization efforts in Iranian cities between 1925 and 1941. This method transformed the urban grid and destroyed historic urban areas; however, it helped transportation tremendously. A city's supergrid is a notion that is superimposed on an existing city structure, triggering a transformation process that results in a complete reorganization of the city's layout, as Moudon stated in 2019. Regular and semi-regular grid patterns and the superimposed modern supergrids have emerged as the dominating pattern of expansion, enclosing the ancient city's organic form inside the confined and transformed historic core. This research's primary methodology is based on the Italian approach of urban morphology, which is focused on the idea that a city's history is written within its built urban fabric. My investigation began by reading the most recent superimposed layers in contemporary time and progressing backward by deleting them in each phase of city formation until I reached the city's origins before the Islamic period. Kashan's morphological cadastral cartographies reveal the city's most recent footprints. The strategy has been implemented by cutting procedures, which superimposed new grids and levels on the medieval town's topography and architecture. The historical aggregate's architectural structure may still be observed inside the modern network. This study examines how the new supergrid axes have changed the behavior of the built fabric on both sides of the route margins.
Those administrative documents are sealed: a study of the evolution of the structure and function of the Egyptian administration in the Late Predynastic and Early Dynastic Period, with specific attention to seals and seal impressions
Creators: name: George, Matthew Warren Bernard
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: The study of the administration in Egypt is ultimately a study of the control that the Egyptian government was able to exert over its population. However, despite the existence of scholarly works on later periods, there is comparatively little knowledge of the administration from the Late Predynastic and Early Dynastic periods. Whilst the wider aim of this research is to provide a comprehensive view of the administration from this time period, this particular study will be focusing on interpreting the information that is provided on seals. This will be undertaken through first examining the origins of the sealing practice in Egypt, then moving onto an analysis of the various types of seals that exist in Egypt. The study then moves into the analysis of the administrative departments and centres and the information that they can provide us in relation to the structures of the administration. Finally our attention turns to the titles present upon these seals and what they can tell us in relation to the administration and ultimately how it functioned.
Cost-effectiveness of tezepelumab in Canada for severe asthma
Creators: name: Habash, Mara
name: Guiang, Hannah
name: Mayers, Irvin
name: Quinton, Anna
name: Vuong, Vivian
name: Dineen, Aidan
name: Singh, Sumeet
name: Gibson, Danny
name: Turner, Adrian P.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Pharmacology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Marine Biology
subject: Science Policy

description: To assess the cost-effectiveness of tezepelumab as add-on maintenance therapy compared with standard of care (SoC) for the treatment of patients with severe asthma in Canada. A cost utility analysis was conducted using a Markov cohort model with five health states (“controlled asthma”, “uncontrolled asthma”, “previously controlled asthma with exacerbation”, “previously uncontrolled asthma with exacerbation”, and “death”). Tezepelumab plus SoC was compared to SoC (high-dose inhaled corticosteroids plus long-acting beta agonist) using efficacy estimates derived from the NAVIGATOR (NCT03347279) and SOURCE (NCT03406078) trials. The model included the costs of therapy, administration, resource use for disease management, and adverse events. Utility estimates were calculated using a mixed-effects regression analysis of the NAVIGATOR and SOURCE trials. A Canadian public payer perspective was used with a 50-year time horizon, a 1.5% annual discount rate, and the base case analysis was conducted probabilistically. A key scenario analysis assessed the cost-effectiveness of tezepelumab compared with currently reimbursed biologics informed by an indirect treatment comparison. The base case analysis suggested that tezepelumab plus SoC was associated with a quality-adjusted life-year (QALY) gain of 1.077 compared with SoC alone at an incremental cost of $207,101 (2022 Canadian dollars), resulting in an incremental cost-utility ratio of $192,357/QALY. The key scenario analysis demonstrated that tezepelumab was dominant against all currently reimbursed biologics, with higher incremental QALYs (ranging from 0.062 to 0.407) and lower incremental costs (ranging from −$6,878 to −$1,974). Additionally, when compared against currently reimbursed biologics in Canada, tezepelumab had the highest probability of being cost-effective across all willingness-to-pay (WTP) thresholds. Tezepelumab provided additional life years and QALYs at additional cost compared with SoC in Canada. In addition, tezepelumab dominated (i.e. more effective, less costly) the other currently reimbursed biologics.
An EMOF-Compliant Abstract Syntax for Bigraphs
Creators: name: Kehrer, Timo
name: Tsigkanos, Christos
name: Ghezzi, Carlo
Publisher: name: arXiv
Year: 2016
Subjects: subject: Software Engineering (cs.SE)
subject: FOS: Computer and information sciences
subject: D.2.2; D.2.10; D.3.1; I.6.5

description: Bigraphs are an emerging modeling formalism for structures in ubiquitous computing. Besides an algebraic notation, which can be adopted to provide an algebraic syntax for bigraphs, the bigraphical theory introduces a visual concrete syntax which is intuitive and unambiguous at the same time; the standard visual notation can be customized and thus tailored to domain-specific requirements. However, in contrast to modeling standards based on the Meta-Object Facility (MOF) and domain-specific languages typically used in model-driven engineering (MDE), the bigraphical theory lacks a precise definition of an abstract syntax for bigraphical modeling languages. As a consequence, available modeling and analysis tools use proprietary formats for representing bigraphs internally and persistently, which hampers the exchange of models across tool boundaries. Moreover, tools can be hardly integrated with standard MDE technologies in order to build sophisticated tool chains and modeling environments, as required for systematic engineering of large systems or fostering experimental work to evaluate the bigraphical theory in real-world applications. To overcome this situation, we propose an abstract syntax for bigraphs which is compliant to the Essential MOF (EMOF) standard defined by the Object Management Group (OMG). We use typed graphs as a formal underpinning of EMOF-based models and present a canonical mapping which maps bigraphs to typed graphs in a natural way. We also discuss application-specific variation points in the graph-based representation of bigraphs. Following standard techniques from software product line engineering, we present a framework to customize the graph-based representation to support a variety of application scenarios.
description: In Proceedings GaM 2016, arXiv:1612.01053
Additional file 4 of Comprehensive analysis of complete chloroplast genome and phylogenetic aspects of ten Ficus species
Creators: name: Huang, Yuying
name: Li, Jing
name: Yang, Zerui
name: An, Wenli
name: Xie, Chunzhu
name: Liu, Shanshan
name: Zheng, Xiasheng
Publisher: name: figshare
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 4: Table S3. Gene with introns in the Ficus species chloroplast genome and the lengths of the introns and exons.
Characterization of the complete mitochondrial genome of the medical fungus Ganoderma resinaceum Boud., 1889 (Polyporales: Ganodermataceae)
Creators: name: He, Mingda
name: Chen, Guangjiu
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Evolutionary Biology
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified

description: The medical mushroom Ganoderma resinaceum Boud., 1889, is of great interest in pharmacy due to its diverse functional active ingredients. However, the mitochondrial genome of G. resinaceum remains unexplored. Here, we present the complete mitochondrial genome of G. resinaceum, which spans 67,458 bp and has a GC content of 25.65%. This genome encompasses 15 core protein-coding genes, 8 independent ORFs, 15 intronic ORFs, 27 tRNAs, and 2 rRNA genes. Through phylogenetic analysis using Bayesian inference (BI), we elucidated the evolutionary relationships among 34 Basidiomycota fungi, revealing distinct clades and indicating a close relationship between G. resinaceum and G. subamboinense.
Interaction of Two Active Region Filaments Observed by NVST and SDO
Creators: name: Yang, Liheng
name: Yan, Xiaoli
name: Li, Ting
name: Xue, Zhike
name: Xiang, Yongyuan
Publisher: name: arXiv
Year: 2017
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: Using high spatial and temporal resolution H$α$ data from the New Vacuum Solar Telescope (NVST) and simultaneous observations from the Solar Dynamics Observatory (SDO), we present a rare event on the interaction between two filaments (F1 and F2) in AR 11967 on 2014 January 31. The adjacent two filaments were almost perpendicular to each other. Their interaction was driven by the movement of F1 and started when the two filaments collided with each other. During the interaction, the threads of F1 continuously slipped from the northeast to the southwest, accompanied by the brightenings at the junction of two filaments and the northeast footpoint of F2. Part of F1 and the main body of F2 became invisible in H$α$ wavelength due to the heating and the motion of F2. At the same time, bright material initiated from the junction of two filaments were observed to move along F1. The magnetic connectivities of F1 were found to be changed after their interaction. These observations suggest that magnetic reconnection was involved in the interaction of two filaments and resulted in the eruption of one filament.
description: 18 pages, 6 figures, accepted by ApJ
Systematic literature review of health economic models developed for multiple myeloma to support future analyses
Creators: name: Choon-Quinones, Mimi
name: Zelei, Tamás
name: Németh, Bertalan
name: Tóth, Manna
name: Jia, Xiao Yang
name: Barnett, Mike
name: Keown, Paul
name: Durie, Brian
name: Harousseau, Jean-Luc
name: Hose, Dirk
name: Kaló, Zoltán
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Medicine
Biotechnology
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Science Policy

description: The goal of this study was to review the economic evaluations of health technologies in Multiple Myeloma (MM) and provide guidance and recommendations for future health economic analyses. A systemic literature review (SLR) was conducted on original economic assessment studies and structured review papers focusing on the studies in MM. The search was limited to English language papers published from January 1, 2000, onwards. Publications not applying any type of modelling methodology to describe disease progression and patient pathways over a specific time horizon were excluded. A total of 2,643 publications were initially identified, of which 148 were eligible to be included in the full-text review phase. From these, 49 publications were included in the final analysis. Most published health economic analyses supported by models came from high-income countries. Evaluations from middle-income countries were rarely published. Diagnostic technologies were rarely modelled and integrated care had not been modelled. Very few models investigated MM treatments from a societal perspective and there was a relative lack of evaluations regarding minimal residual disease (MRD). Limitations of the publications included differences between trial populations and modelled populations, justification of methods, lack of confounder analyses, and small trial populations. Limitations of our study included the infeasibility of comparing MM economic evaluations due to the significant variance in modelled therapeutic lines and indications, and the relative scarcity of published economic evaluations from non-high-income countries. As published economic models lacked many of the elements of the complex and heterogeneous patient pathways in MM and they focused on single decision problems, a thorough, open-source economic whole disease modelling framework is needed to assess the economic value of a wide range of technologies across countries with various income levels with a more detailed view on MM, by including patient-centric and societal aspects.
Twitter and the transformation of the public sphere: an analysis of asylum seeker narratives in the new media landscape
Creators: name: Dunn, Rebecca Mary
Publisher: name: Macquarie University
Year: 2022
Subjects: Other education not elsewhere classified

description: This thesis reports on a research project investigating the different ways that asylum seekers are represented in the Australian print media and social media. The study involves textual analysis of print media reports and social media discussion of asylum seekers over two separate eight-day periods during 2013 and 2014. In light of the discourses conveyed by the analysis of the two types of media, the primary question that the thesis considers is how do the print media and social media contribute to and interact in the public sphere in relation to the issue of asylum seekers? Supplementary key research questions which inform this overarching investigation include whether mainstream print media provides the requisite interrogation of public policy necessary for a healthy public sphere; whether and in what manner social media impacts on public communication about political issues; and whether social media enables members of the public to participate in and disrupt traditional media narratives about asylum seekers. The thesis findings include that the print media discussed asylum seeker policy on the basis of its political merits, and conveyed dominant narratives in relation to asylum seekers constructing them as a problem to be solved on the basis of their illegitimacy, immorality and criminality (consistent with the approach adopted and the narratives conveyed by the two major political parties). By contrast, analysis of the data indicated that social media provided an opportunity to disrupt those dominant narratives and convey alternatives that engaged with the experience of asylum seekers. Against the backdrop of those findings, this thesis considers the respective roles of the mainstream media and social media in the public sphere, drawing on the theories of Jürgen Habermas in relation to the role of the public sphere in a functioning democracy. It concludes that social media enhances the dialogue about politics and society that is ever present in the public sphere, by enabling competing voices to be heard and to engage with one another.
Cost-effectiveness of pembrolizumab as an adjuvant treatment for patients with resected stage IIB or IIC melanoma in Switzerland
Creators: name: Favre-Bulle, Andrea
name: Bencina, Goran
name: Zhang, Shujing
name: Jiang, Ruixuan
name: Andritschke, Daniel
name: Bhadhuri, Arjun
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: To assess the cost-effectiveness of adjuvant pembrolizumab versus observation for patients with resected stage IIB/IIC melanoma from a third-party payers’ perspective in Switzerland over a lifetime horizon. A Markov state transition model with four health states (recurrence-free [RF], locoregional recurrence, distant metastases [DM], and death) was developed to determine the cost-effectiveness of pembrolizumab versus observation as an adjuvant treatment in patients with stage IIB/IIC melanoma who have undergone complete resection. The model utilized data from the KEYNOTE-716 randomized controlled trial (ClinicalTrials.gov, NCT03553836). The incremental cost-effectiveness ratio (ICER) (Swiss Franc [CHF] per life year or quality-adjusted life years [QALYs] gained) was calculated. A probabilistic sensitivity analysis and deterministic sensitivity analysis were conducted to assess the robustness of the base case results. Model results demonstrated that pembrolizumab is highly cost-effective as an adjuvant treatment for resected stage IIB/IIC melanoma versus observation in Switzerland. Base case results showed an ICER of CHF 27,424/QALY (EUR 27,342/QALY; exchange rate: 1 CHF = 0.997 EUR) for pembrolizumab versus observation. Results were most sensitive to changes to transition probabilities from the RF state. Most sensitivity and scenario analyses resulted in ICERs below the willingness-to-pay threshold (WTP) of CHF 100,000. At this WTP, pembrolizumab had a 78.9% probability of being cost-effective versus observation. Due to a limited follow-up period in the KEYNOTE-716 trial, data from other clinical trials in the advanced melanoma setting were synthesized in a network meta-analysis and used to inform transition probabilities from DM to death in the cost-effectiveness model, to overcome the absence of these data from the trial. The model demonstrated that pembrolizumab is highly cost-effective versus observation in patients with resected stage IIB/IIC melanoma in Switzerland. The ICER was below the WTP threshold of CHF 100,000, commonly used for cost-effectiveness models in Switzerland.