cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Power devices and integrated circuits based on 4H-SiC lateral JFETs
Creators: name: Su, Ming
Publisher: name: No Publisher Supplied
Year: 2010

description: Silicon carbide (SiC) is a wide-bandgap semiconductor that has drawn significant research interest for the next-generation power electronics due to its superior electrical properties. Excellent device performance has been repeatedly demonstrated by SiC vertical power devices. However, for lateral power devices that offer the unique advantage of possible monolithic integration of a power electronics system-on-chip, the progress has been limited. This dissertation describes the 4H-SiC vertical-channel lateral JFET (VC-LJFET) technology that provides a suitable solution for power integration applications. Power devices based on this structure have a trenched-and-implanted vertical channel and a carefully designed lateral drift region, enabling normally-off operation with a high-voltage blocking capability. Low-voltage (LV) versions of VC-LJFET feature nearly identical device structures with a reduced drift length, and can be readily fabricated on the same wafer with the power devices. Essential components for a power integrated circuit, such as gate drive buffers, can be thus implemented monolithically on the VC-LJFET technology platform.    This dissertation research starts with the process improvement investigation for the TI-JFET structure. Particularly, a novel ohmic contact scheme is developed using Ni to replace the troubling process in TI-VJFETs. The entire process flow of VC-LJFET is then designed and demonstrated in experiments, leading to the world’s first demonstration of a normally-off lateral power JFET in SiC. As of today, power JFETs fabricated in this technology are still representing the best-performing lateral power transistors in SiC and silicon.   Based on the VC-LJFET structure, low-voltage circuits critical to the power integration applications are investigated. Gate drive buffer provides the interface between low-voltage control circuits and the power device, and is recognized as a key component for an integrated power electronics system. A thorough design, modeling and optimization work on the LJFET-based gate drive circuits is described. These buffer drivers using resistor or transistor loads will enable high-frequency switching of the power LJFETs at megahertz levels.   The results achieved in this research strongly suggest the feasibility of SiC power integration technologies in general, as well as the suitability of the SiC VC-LJFET platform for such applications in particular.
Protolabeo protolabeo Zhang, Zhao & Liu 2010
Creators: name: Ye, Enqi
name: Xing, Yingchun
name: Zhang, Chunguang
name: Zhao, Yahui
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Cypriniformes
Cyprinidae
Protolabeo
Protolabeo protolabeo

description: Protolabeo protolabeo Zhang, Zhao & Liu, 2010 (Fig. 29)
Holotype. 182233 (2009-002), Upper Lihe River: Maojiacun Reservoir, Jinzhong Town, Huize County, Yunnan Province, P. R. China, Jan., 2009.
Paratypes. 182232 (2009-001), 182234-182236 (2009-003-2009-005), collected with holotype.
description: Published as part of Ye, Enqi, Xing, Yingchun, Zhang, Chunguang & Zhao, Yahui, 2015, Catalogue of the type specimens in the fish collection of the National Zoological Museum, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, pp. 10-113 in Zootaxa 3962 (1) on page 38, DOI: 10.11646/zootaxa.3962.1.4, http://zenodo.org/record/233837
Identification and expression of the cytochrome P450 reductase gene in Aedes sollicitans (Walker) (Diptera: culicidae)
Creators: name: Sun, Debin
Publisher: name: No Publisher Supplied
Year: 2010

description: Aedes sollicitans (Walker) is an important vector of mosquito-borne diseases. Cytochrome P450 system is one of the most important enzyme families involved in the metabolic responses of living organisms to foreign chemicals. To explore the specific functions of individual cytochrome P450s, it is important to identify the cytochrome P450 reductase gene.    The cytochrome P450 reductase genes were identified in Ae. sollicitans from Cape May, Middlesex and Ocean County, New Jersey. The cytochrome P450 reductase gene has an open reading frame of 2040 bp encoding 679 amino acid residues. The comparison among 679 amino acid residues deduced from the cytochrome P450 reductase gene obtained from three mosquito populations showed that mutations had occurred at the nucleotide level but did not produce amino acid changes except in one case. In Ocean County mosquito population, the amino acid serine was changed to glycine. The amino acid change was not considered to cause any functional change of cytochrome P450 reductase since the mutation was not located in any functional region. Quantitative real-time expression analysis showed that the expressions of CYP6BB1 and cytochrome P450 reductase mRNAs were not significantly different in fourth instar larvae or in different body parts of adult female mosquitoes in populations from three locations. The study implied that CYP6BB1 was ubiquitously expressed in female mosquitoes and its expression occurred in both larvae and adults.  The cytochrome P450 reductase gene was expressed in E. coli cells and molecular mass of the protein was estimated to be 78 kDa. Its activity was assayed in both the cytosolic and cell membrane fractions. The activity in the cytosol was much higher than that in the membrane fractions.  The cytochrome P450 reductase activities in microsomes of Ae. sollicitans collected from the three locations were assayed. The results showed no statistically significant differences. This is the first study of cytochrome P450 reductase in Ae. sollicitans. The identification and expression of the cytochrome P450 reductase gene provide further insights on how cytochrome P450s metabolize substrates and make it possible to explore the specific functions of each cytochrome P450 gene. The study is not only meaningful for Ae. sollicitans but also for other mosquito species.
Mideopsellides K.O. Viets 1962
Creators: name: Pešić, Vladimir
name: Cook, David
name: Gerecke, Reinhard
name: Smit, Harry
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Mideopsidae
Mideopsellides

description: Genus Mideopsellides K.O. Viets, 1962
description: Published as part of Pešić, Vladimir, Cook, David, Gerecke, Reinhard & Smit, Harry, 2013, The water mite family Mideopsidae (Acari: Hydrachnidia): a contribution to the diversity in the Afrotropical region and taxonomic changes above species level, pp. 1-75 in Zootaxa 3720 (1) on page 64, DOI: 10.11646/zootaxa.3720.1.1, http://zenodo.org/record/285029
Ptychidio macrops Fang 1981
Creators: name: Ye, Enqi
name: Xing, Yingchun
name: Zhang, Chunguang
name: Zhao, Yahui
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Cypriniformes
Cyprinidae
Ptychidio
Ptychidio macrops

description: Ptychidio macrops Fang, 1981 (Fig. 30)
Holotype. 60281 (A042), Yongjiang River, Nanning City, Guangxi Province, P. R. China, Jul., 1974. Paratypes. 60282 (750226), locality with holotype, Mar. 22, 1975; 60283-60284 (751776-751777), Zuojiang River basin: Longzhou County, Guangxi Province, P. R. China, Nov. 11, 1975.
description: Published as part of Ye, Enqi, Xing, Yingchun, Zhang, Chunguang & Zhao, Yahui, 2015, Catalogue of the type specimens in the fish collection of the National Zoological Museum, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, pp. 10-113 in Zootaxa 3962 (1) on page 39, DOI: 10.11646/zootaxa.3962.1.4, http://zenodo.org/record/233837
Early identification of the nosocomial spread of vancomycin-resistant Enterococcus faecium by Fourier-transform infrared spectroscopy and performance comparison with PFGE and WGS
Creators: name: Pitart, Cristina
name: Piquet, Maria
name: Burgwinkel, Tessa
name: Del Pino, Rocío Arazo
name: Rubio, Marc
name: Aguilar, Mireia
name: De Gea, Sergi
name: Pulgarín, Andrea
name: Campo, Irene
name: Torralbo, Blanca
name: Parejo, Romina
name: Valls, Silvia
name: Fortes, Isabel
name: Santana, Gemina
name: Rubio, Elisa
name: Vilella, Anna
name: Del Río, Ana
name: Martínez, José Antonio
name: Miró, Elisenda
name: Navarro, Ferran
name: Espasa, Mateu
name: Casals-Pascual, Climent
name: Vila, Jordi
name: Higgins, Paul G.
name: Roca, Ignasi
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Early detection of disseminating vancomycin-resistant Enterococcus faecium (VREfm) in ICU wards is crucial for outbreak identification and the implementation of prompt infection control measures. Genotypic methods like pulsed-field gel electrophoresis (PFGE) and whole-genome sequencing (WGS) are costly and time-consuming, hindering rapid response due to batch dependency. Fourier-transform infrared spectroscopy (FT-IR) offers the potential for real-time outbreak detection and reliable strain typing. We utilized FT-IR to identify clonal VREfm dissemination and compared its performance to PFGE and WGS. Between February through October 2023, an unusually high number of VREfm were recovered at a tertiary hospital in Barcelona. Isolates were examined for antimicrobial susceptibility, carriage of vanA/vanB genes and clonality was also studied using FT-IR, PFGE, and WGS. Routine FT-IR inspections revealed recurring VREfm clustering during the outbreak's initial weeks. In total, 104 isolates were recovered from 75 patients and from multiple wards. However, only one isolate was recovered from an environmental sample, suggesting the absence of environmental reservoirs. An ST80 vancomycin-resistant (vanA) E. faecium strain was the main strain responsible for the outbreak, although a few additional VREfm strains were also identified, all belonging to CC17. PFGE and cgMLST (WGS) yielded identical clustering results to FT-IR, and WGS confirmed vanA/vanB gene carriage in all VREfm isolates. Infection control measures led to a rapid decline in VREfm isolates, with no isolates detected in November. FT-IR spectroscopy offers rapid turnaround times, sensitivity, and reproducibility, comparable to standard typing methods. It proved as an effective tool for monitoring VREfm dissemination and early outbreak detection.
Amblyseius excelsus Chaudhri, Akbar & Rasool 1979
Creators: name: KamranK, Muhammad
name: AlatawiK, Fahad Jaber
Publisher: name: Zenodo
Year: 2024
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Mesostigmata
Phytoseiidae
Amblyseius
Amblyseius excelsus

description: Amblyseius excelsus Chaudhri, Akbar & Rasool (Figures 1–4)
Amblyseius excelsus Chaudhri, Akbar and Rasool, 1979: 68.
description: Published as part of KamranK, Muhammad & AlatawiK, Fahad Jaber, 2024, Complementary description of three Amblyseius species (Acari: Mesostigmata ; Phytoseiidae) and keys to the world species of duncansoni and largoensis species subgroups, pp. 925-940 in Acarologia 64 (3) on page 926, DOI: 10.24349/hr32-1gg9, http://zenodo.org/record/14670336
A dose finding method in joint modeling of efficacy and safety  endpoints in phase II studies
Creators: name: Tao, Aiyang
Publisher: name: No Publisher Supplied
Year: 2010

description: Determination of appropriate dose(s) to advance into Phase III is one of the  most challenging and important decisions made during drug development.  Selecting a dose too high may result in unacceptable safety problems, while  a too low dose may lead to ineffective drugs. Proper estimation of such  dose-response profiles for relevant safety and efficacy endpoints allows the  reliable evaluation of the risk-benefit profile of a drug at the end of  Phase II, as well as the selection of appropriate doses to be brought into  confirmatory Phase III trials. This dissertation will address how to select  dose(s) in Phase II trials by combining information about the efficacy and  safety in a joint model setting. The methods we present in the dissertation  may play a key role in drug development programs, and are often the  gate-keeper for large confirmatory Phase III  trials with greater chance of  successful approval. The dose selection when both safety and efficacy are represented by  continuous responses is discussed in Part I of the dissertation, while Part  II addresses the methodology when the safety and efficacy are mixed type responses. Both scenarios involve joint modeling of safety and efficacy  endpoints. The methodology will focus on the following: (1) Joint modeling  approaches; (2) Model selection; (3) Identification of minimum effective  dose (MED) and maximum safety dose(MSD); (4) Selection of optimal  dose(s) for the Phase III program.
Rugogymnocypris tibetanus Yue & Huang 1964
Creators: name: Ye, Enqi
name: Xing, Yingchun
name: Zhang, Chunguang
name: Zhao, Yahui
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Cypriniformes
Cyprinidae
Rugogymnocypris
Rugogymnocypris tibetanus

description: Rugogymnocypris tibetanus Yue & Huang, 1964 (Fig. 31)
= Gymnocypris waddellii Regan, 1905
Holotype. 43774 ♀ (TS-047), Yamzho Lake, Baidi Village, Langkazi County, Xizang Province, P. R. China, May 22, 1961.
description: Published as part of Ye, Enqi, Xing, Yingchun, Zhang, Chunguang & Zhao, Yahui, 2015, Catalogue of the type specimens in the fish collection of the National Zoological Museum, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, pp. 10-113 in Zootaxa 3962 (1) on page 41, DOI: 10.11646/zootaxa.3962.1.4, http://zenodo.org/record/233837
Mediation in civil wars
Creators: name: Tiemann, Andreas
Publisher: name: No Publisher Supplied
Year: 2010

description: In the recent past, mediation, a special kind of Alternative Dispute Resolution (ADR), has become a both more frequent and more successful tool to reach peaceful settlements in civil wars. Nevertheless, current research still does not understand what triggers the occurrence of mediation and which factors determine its failure or success. This research paper aims to answer these questions, deriving a comprehensive theoretical framework and corresponding research hypotheses from a literature review. Taking into account debates on the conceptualization and operationalization of the key variables in question, these hypotheses are subjected to an empirical test, analyzing a data-set including 68 civil wars in the time span 1945-1999. In doing so, for the first time, the ordinal nature of mediation outcomes is taken into account when modeling both the incidence of mediation and potential determinants of its outcome jointly. The results question a large number of hypotheses found in the literature, asking for a better theoretical underpinning of the subject matter. Particularly, while mediation occurrence can be explained rather well, a lack of knowledge remains concerning success factors of mediation. Moreover, adding to discussions on a mediator's agency within structural constraints, none of the variables within the reach of a mediator's direct influence were found to be significant predictors of mediation success.
Novel high volumetric energy density nanostructured electrode materials for biomedical applications
Creators: name: Tong, Wei
Publisher: name: No Publisher Supplied
Year: 2010

description: A definitive focus is being made to develop cathode materials of higher energy and good power for primary and rechargeable lithium batteries upon the development of implantable biomedical devices (cardiac defibrillators). In this thesis, novel electroactive nanostructured silver metal oxyfluoride perovskites, Ag1+3Mo6+(O3F3) and Ag1+3Nb5+(O2F4) have been successfully synthesized by a mechanochemical reaction. The formation of these perovskites was investigated throughout the Ag-Mo / Nb composition range with the use of either Ag1+ or Ag2+ in the form of AgF and AgF2 as the reactant, respectively. The compositional study combined with XRD and extensive Raman investigation was utilized to determine structure and cation distribution and infer oxidation state. An electrochemical characterization of these silver metal oxyfluoride perovskite positive electrodes for Li batteries was investigated for the first time as a function of synthesis condition, stoichiometry and effect of Mo and Ag derived second phases. A detailed in-situ electrochemical study by XAS, Raman and XRD was performed, revealing a 3 electron silver displacement or conversion reaction at > 3 V and a 2 electron reduction of Mo6+ to Mo4+ in the region < 3 V. To further improve the rate capability of silver metal oxyfluorides, metallic Ag2F phase has been successfully synthesized through the mechanochemical reaction of Ag and AgF. Its unique metallic character within Ag layers lead to a very good electronic conductivity (7.89×10-2 S/cm). The efficacy of SMOF composites consisting of conducting matrix (carbon black, Ag2F and Ag phase) for lithium battery was investigated through discharge rate studies. Results indicated that Ag2F phase could be utilized as an alternative conductive additive with exceptional density.
Usable Web 2.0 privacy management and medical imaging search
Creators: name: Vyas, Nitya
Publisher: name: No Publisher Supplied
Year: 2010

description: Ontology is the study of categorization of concepts and their relations. In this thesis, I provide insight towards an idea of using ontology-based approach for systems of which I present it in two different contexts. First application is in User Privacy Management in Web 2.0 and the other is in Medical Imaging Search. Both applications use user-defined annotations within a standard framework to achieve the desired results. The central idea of our technique is that users are not required to have prior knowledge about the structure of the ontology to use the system. In the first application we use annotated data in Web 2.0 social networking applications to predict privacy preferences of users and automatically derive policies for shared content. We carry out a series of user studies to evaluate the accuracy of our prediction techniques. Our analysis gives encouraging results on the feasibility of using annotations for privacy management in Web 2.0. The second application is a system for annotation and retrieval of medical images, and is built on semantic web standards. By annotating data according to standard medical ontologies, it allows the user to construct complex queries that utilize background knowledge from the underlying ontologies. Our ontology-based approach allows for several features not available in existing keyword-based search engines.
Semilabeo obscurus Lin & Zheng 1981
Creators: name: Ye, Enqi
name: Xing, Yingchun
name: Zhang, Chunguang
name: Zhao, Yahui
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Cypriniformes
Cyprinidae
Semilabeo
Semilabeo obscurus

description: Semilabeo obscurus Lin & Zheng, 1981 (Fig. 32)
Paratype (holotype has been lost): 60285 (750610), Youjiang River basin: Yangxu Town, Baise City, Guangxi Province, P. R. China, Mar. 31, 1975.
description: Published as part of Ye, Enqi, Xing, Yingchun, Zhang, Chunguang & Zhao, Yahui, 2015, Catalogue of the type specimens in the fish collection of the National Zoological Museum, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, pp. 10-113 in Zootaxa 3962 (1) on page 41, DOI: 10.11646/zootaxa.3962.1.4, http://zenodo.org/record/233837
Mideopsellides geae K.O. Viets 1962
Creators: name: Pešić, Vladimir
name: Cook, David
name: Gerecke, Reinhard
name: Smit, Harry
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Mideopsidae
Mideopsellides
Mideopsellides geae

description: Mideopsellides geae K.O. Viets, 1962
(Figs. 41D–E, 42A–F)
New records: South Africa: DC 102 84 Eastern Cape Province, Kaaimans River E of George, 5–10 m wide, sand & rocks, stained, good flow (9.5 ˚C), 10.vi.1984 Cook 7/5/0 (mounted); West Cape Province, Bloukrans River at crossing with Road R 102, 15.xi.2004 Smit 1/0/0.
Distribution: South Africa (Eastern Cape Province—K.O. Viets 1962; present study).
description: Published as part of Pešić, Vladimir, Cook, David, Gerecke, Reinhard & Smit, Harry, 2013, The water mite family Mideopsidae (Acari: Hydrachnidia): a contribution to the diversity in the Afrotropical region and taxonomic changes above species level, pp. 1-75 in Zootaxa 3720 (1) on page 64, DOI: 10.11646/zootaxa.3720.1.1, http://zenodo.org/record/285029
Brucellosis Seroprevalence in Cattle in China During 2014–2024: A Systematic Review and Meta-analysis
Creators: name: Tian, Zihan
name: Wan, Liyun
name: Pei, Jie
name: Li, Tingting
name: Wang, Xiaozhong
name: Yuan, Peng
name: Guo, Aizhen
name: Chen, Yingyu
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Neuroscience
subject: Environmental Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Cancer

description: Brucellosis, caused by several species of Brucella, continues to be a significant illness that poses a global threat to public health. China remains a persistent hotspot for brucellosis, despite the implementation of extensive control measures. This study aims to conduct a systematic review and meta-analysis of the seroprevalence of bovine brucellosis in different breeds and regions of China from 2014-2024, and to provide predictions on the future prevalence patterns of brucellosis in cattle and humans. The analysis comprised a total of 80 research studies, which consisted of 187 datasets and a combined sample size of 3,130,706. We estimated the overall pooled seroprevalence of bovine brucellosis in China to be 1.5% (95% CI: 0.6-2.6%). Subgroup analysis revealed that the seroprevalence in dairy cattle was 3.1%, surpassing the seroprevalence in beef cattle (1.3%) and yak (1.5%). Regions that had authorized vaccination programs exhibited higher seroprevalence (1.8%) compared to regions that did not have vaccination (0.5%). Notably, the study observed a simultaneous rise in both the prevalence of brucellosis in cattle and the number of human brucellosis cases. This suggests that high-quality routine surveillance of brucellosis in cattle will be essential for predicting and responding to cases in humans. Additionally, given the existing prevention and control measures, brucellosis will likely continue to be prevalent in both cattle and people. This systematic review will assist policymakers in adjusting animal surveillance and interregional livestock movement policies, ultimately contributing to the public safety goal of preventing brucellosis in humans by controlling it in animals.
Extension of cure rate model when cured is partially known
Creators: name: Wu, Yu
Publisher: name: No Publisher Supplied
Year: 2010

description: When there is evidence of long term survivors, cure rate models have been used by researchers to model the tail behavior of the survival curve.  Mixture models were traditionally used, and different parameter estimation approaches for parametric and semi-parametric models have been suggested.  A common aspect of the traditional cure rate models is that they implicitly assume there is no additional information about the status of cure, thus the indicator of cure has been modeled as latent variable. This assumption is not entirely valid in many cases, when some diagnostic procedure can provide information about the status of cure. This dissertation proposes a novel extension to incorporate the additional information about status of cure in the cure rate models. It also shows that, with this additional information, more efficient estimator can be obtained. The efficiency gain increases with better sensitivity and specificity of the diagnostic procedure.  The efficiency gain is larger when the censoring rate is high. This extension can be applied when the latency part is modeled parametrically, semi-parametrically, or non-parametrically. Both proportional hazards (PH) cure rate models and accelerated failure time (AFT) cure rate models can use this model extension. Simulation study and a case study results are presented.
Albumin-derived nanoparticles
Creators: name: Xu, Jing
Publisher: name: No Publisher Supplied
Year: 2010

description: Mesenchymal stem cells (MSCs) are multipotent stem cells that can differentiate into a variety of cell types and have been widely investigated as a possible alternative treatment strategy for wound healing. A major challenge to the direct application of MSCs in severe wounds is the limited engraftment of these cells at the wound sites (<1%) and a lack of spatial control of MSC adhesion and activation, which could be potentially enhanced through engineered nanoscale multifunctional substrates. The use of human albumin-derived nanoparticles (ANPs) as a foundational nanoscale substrate to display RGD-containing fibronectin FIII9-10 fragment (Abbreviated: Fnf) has been previously reported in the Moghe laboratory. When presented in 2-D cell cultures on ANPs, this ligand has been proven to promote cell motility and extracellular matrix assembly. Here we showed Fnf-ANPs promoted human MSCs (hMSCs) adhesion as well as integrin clustering in cell protrusions and were able to spatially direct the adhesion and growth of hMSC on 2-D polymer substrates. Furthermore, hMSC morphology and its organization of focal adhesion were sensitively modulated by nanoscale size of ANPs. The adhesion of hMSC was cooperatively promoted in the presence of Fnf-ANPs and growth factor, bFGF. In order to promote similar synergies between the biofunctionalized ANPs and growth factors, we engineered albumin nanoparticles with P14 peptide, a fibronectin-derived growth factor sequestering peptide proven to bind to a variety of growth factors. Thus, we demonstrate that albumin-derived nanoparticles can be used as a flexible system for nanoscale presentation of adhesion and growth factors, the combination of which could potentially control hMSC phenotype and functions.
Physiological, biochemical and molecular factors associated with heat tolerance in bentgrass (Agrostis spp.)
Creators: name: Xu, Yan
Publisher: name: No Publisher Supplied
Year: 2010

description: High temperature is a major factor limiting the growth of cool-season plant species during summer. Understanding mechanisms of plant tolerance to high temperature would help develop effective management practices and heat-tolerant cultivars through breeding or biotechnology. This dissertation research explored physiological, biochemical and molecular mechanisms for improving heat tolerance in two bentgrass species, creeping bentgrass (Agrostis stolonifera L.), a widely used cool-season grass species on golf course tees and putting greens, and thermal rough bentgrass (Agrostis scabra Willd.) adapted to geothermal areas in Yellowstone National Park. The dissertation reports research in three main components. The first section compared differential heat-induced metabolism of hormones, proteins and metabolites between heat-sensitive creeping bentgrass and heat-tolerant A. scabra. Based on the findings that heat tolerance of bentgrass was associated with changes in stress-related hormone levels, the effects of foliar-applied hormone or hormone inhibitors on creeping bentgrass to enhance heat tolerance were further studied. Results from both growth chamber and field studies confirmed the effectiveness of applying hormones or hormone-based plant growth regulators on alleviating heat injuries in creeping bentgrass. In the last part of the dissertation, a few transgenic creeping bentgrass lines with improved heat tolerance were characterized. These transgenic lines carry a gene (ipt) controlling cytokinin synthesis. Increased ipt gene expression and cytokinin levels were confirmed and changes in morphological and physiological traits of the plants were examined. Genome-wide protein responses to the addition of the gene and their association with heat tolerance were discussed. The results indicated that transformation with the ipt gene induced protein changes involved in multiple functional groups, mainly in energy, protein destination and storage, and disease/defense categories in both leaves and roots of creeping bentgrass, thus cytokinins may have regulatory roles in multiple metabolic pathways for heat tolerance. Taken together, these studies suggest summer performance of creeping bentgrass may be improved by properly applying hormone-based plant growth regulators or biostimulants, and incorporating molecular markers developed from heat- and/or hormone-responsive proteins and metabolites may facilitate selection of heat-tolerant creeping bentgrass cultivars.
The safety, immunogenicity, and efficacy of heterologous boosting with a SARS-CoV-2 mRNA vaccine (SYS6006) in Chinese participants aged 18 years or more: a randomized, open-label, active-controlled phase 3 trial
Creators: name: Zhou, Chunhua
name: Qiu, Yuanzheng
name: Wang, Jianxin
name: Zhong, Xiang
name: Zhu, Xiufang
name: Huang, Xiaojing
name: Yang, Lan
name: Ji, Qiaolei
name: Zhou, Feifei
name: Wu, Shunquan
name: Yang, Mengjie
name: Zhang, Jing
name: Liu, Kaili
name: Ji, Li
name: Yang, Hanyu
name: Li, Chunlei
name: Zhao, Yuanyuan
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Continuous emergence of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), enhanced transmissibility, significant immune escape, and waning immunity call for booster vaccination. We evaluated the safety, immunogenicity, and efficacy of heterologous booster with a SARS-CoV-2 mRNA vaccine SYS6006 versus an active control vaccine in a randomized, open-label, active-controlled phase 3 trial in healthy adults aged 18 years or more who had received two or three doses of SARS-CoV-2 inactivated vaccine in China. The trial started in December 2022 and lasted for 6 months. The participants were randomized (overall ratio: 3:1) to receive one dose of SYS6006 (N = 2999) or an ancestral receptor binding region-based, alum-adjuvanted recombinant protein SARS-CoV-2 vaccine (N = 1000), including 520 participants in an immunogenicity subgroup. SYS6006 boosting showed good safety profiles with most AEs being grade 1 or 2, and induced robust wild-type and Omicron BA.5 neutralizing antibody response on Days 14 and 28, demonstrating immunogenicity superiority versus the control vaccine and meeting the primary objective. The relative vaccine efficacy against COVID-19 of any severity was 51.6% (95% CI, 35.5–63.7) for any variant, 66.8% (48.6–78.5) for BA.5, and 37.7% (2.4–60.3) for XBB, from Day 7 through Month 6. In the vaccinated and infected hybrid immune participants, the relative vaccine efficacy was 68.4% (31.1–85.5) against COVID-19 of any severity caused by a second infection. All COVID-19 cases were mild. SYS6006 heterologous boosting demonstrated good safety, superior immunogenicity and high efficacy against BA.5-associated COVID-19, and protected against XBB-associated COVID-19, particularly in the hybrid immune population. Trial registration: Chinese Clinical Trial Registry: ChiCTR2200066941
Multivariate autoregressive modular processes
Creators: name: Zhao, Xiang
Publisher: name: No Publisher Supplied
Year: 2010

description: This thesis defines a new class of vector-valued stochastic processes, called MARM (Multivariate Autoregressive Modular) Processes.  It describes the construction of two flavors of MARM processes, MARM+ and MARM−, studies the statistics of MARM processes (transition structure and second order statistics), and devises MARM-based fitting and forecasting algorithms providing point estimators and confidence intervals.  The key advantage of MARM processes is their ability to fit a strong statistical signature consisting of empirical first-order and second-order statistics simultaneously.  More precisely, MARM processes exactly fit arbitrary multi-dimensional empirical histograms and approximately fit the leading empirical autocorrelations and cross-correlations functions.  This ability appears to make the MARM modeling methodology unique in its goal of fitting a model to such a class of strong statistical signatures.  Furthermore, the thesis proposes practical MARM modeling and forecasting methodologies of considerable generality, suitable for implementation on a computer.  We demonstrate the efficacy of these methodologies with an example of a three-dimension time series vector, using a software environment, called MultiArmLab, which supports MARM modeling and forecasting.
Polybrominated diphenyl ethers in NY.NJ harbor and lower Delaware River Valley areas
Creators: name: Zarnadze, Archil
Publisher: name: No Publisher Supplied
Year: 2010

description: Present dissertation is a compilation of several projects implemented at the disarmament of Environmental Science of Rutgers University under the supervision of Lisa A. Rodenburg. The goal of this work was to describe the fate and transport of Polybrominated Diphenyl Ethers (PBDEs) in North-East region of the United States. Chapter 1 of this dissertation outlines background information on PBDEs, their occurrence history and environmental and health problems associated with them. Chapter 2 analyzes atmospheric (particle, gas and rain) levels of PBDEs in NY/NJ Harbor. Atmospheric levels of BDEs in this region fall into the range of the values reported by other studies in US and around the world. Chapter 3 reveals high water column levels of PBDEs in Raritan Bay of NY/NJ harbor (relative to other aquatic systems in US and around the world) concluding that atmospheric deposition is not the main source of BDEs in the NY/NJ Harbor. Dry particle and wet deposition fluxes, as well as annual load of BDEs, are estimated in this chapter. Chapter 4 deals with atmospheric levels of BDEs in lower Delaware River valley, obtained by passive air sampling (PAS) methodology. This is the first study that describes BDEs in this region.   Overall, atmospheric levels of BDEs are correlated with temperature but mostly in gas phase rather than in particle phase. Overall, PBDE concentrations do not show significant relationship with population density. Although, some congeners (BDE 47) show stronger relationship with population density at NY/NJ harbor and lower Delaware River valley, than others (BDE 99 and BDE 209).  Gas-particle partitioning is important aspect of PBDE removal from the environment and was investigated in this dissertation. Also, water column partitioning between truly dissolved and particle phases was analyzed. While heavy molecular weight congener BDE 209 was predominantly found in particle (air) and particulate (water) phases, light congener BDE 47 was predominantly detected in gas (air) and truly dissolved (water) phases, and therefore, being more inclined for long range transport in the environment. As a result, unlike gas phase congeners, particle phase BDE congeners show strong Penta-BDE (BDE 47 and BDE 99) and Deca-BDE (BDE 209) commercial mixture signature at these regions.
Additional file 3: of Effectiveness of real-time polymerase chain reaction assay for the detection of Mycobacterium tuberculosis in pathological samples: a systematic review and meta-analysis
Creators: name: Babafemi, Emmanuel
name: Cherian, Benny
name: Banting, Lee
name: Mills, Graham
name: Kandala Ngianga
Publisher: name: Figshare
Year: 2017
Subjects: subject: Molecular Biology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Quality assessment of diagnostic accuracy. (DOC 49 kb)
Sinocyclocheilus brevibarbatus Zhao, Lan & Zhang 2009
Creators: name: Ye, Enqi
name: Xing, Yingchun
name: Zhang, Chunguang
name: Zhao, Yahui
Publisher: name: Zenodo
Year: 2015
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Actinopterygii
Cypriniformes
Cyprinidae
Sinocyclocheilus
Sinocyclocheilus brevibarbatus

description: Sinocyclocheilus brevibarbatus Zhao, Lan & Zhang, 2009 (Fig. 33)
Holotype. 74228 (01060406), Gaoling Town, Du’an County, Guangxi Province, P. R. China, Jun., 2001. Paratypes. 74229 (01060404), 93900-93904, collected with holotype.
description: Published as part of Ye, Enqi, Xing, Yingchun, Zhang, Chunguang & Zhao, Yahui, 2015, Catalogue of the type specimens in the fish collection of the National Zoological Museum, Institute of Zoology, Chinese Academy of Sciences, Beijing, China, pp. 10-113 in Zootaxa 3962 (1) on page 42, DOI: 10.11646/zootaxa.3962.1.4, http://zenodo.org/record/233837
Phreatomideopsis Schwoerbel 1986
Creators: name: Pešić, Vladimir
name: Cook, David
name: Gerecke, Reinhard
name: Smit, Harry
Publisher: name: Zenodo
Year: 2013
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Trombidiformes
Mideopsidae
Phreatomideopsis

description: Genus Phreatomideopsis Schwoerbel, 1986
description: Published as part of Pešić, Vladimir, Cook, David, Gerecke, Reinhard & Smit, Harry, 2013, The water mite family Mideopsidae (Acari: Hydrachnidia): a contribution to the diversity in the Afrotropical region and taxonomic changes above species level, pp. 1-75 in Zootaxa 3720 (1) on page 64, DOI: 10.11646/zootaxa.3720.1.1, http://zenodo.org/record/285029
Thinking the body transcendent
Creators: name: Sierra, Erick Samuel
Publisher: name: No Publisher Supplied
Year: 2010

description: Twentieth-century literature and theory have offered no shortage of challenges to the unity of personal identity. What these undertakings leave largely unquestioned, however, is the prevailing understanding that personal identity is sealed within the confines of the physical body—the final uncontested frontier of Cartesian identity. Emerging from a matrix of recent American literature—by Don DeLillo, Charles Johnson, Tony Kushner, Toni Morrison, among others—is a counter-argument to the notion that the materially bounded self is separate from other such selves in space. For the “individual” to take shape as such, it must locate itself within a specific social identity, disavowing its connection with those who identify themselves differently: a process, these texts suggest,that can unleash racial and ideological violence. My dissertation explores six late twentieth-century American novels and plays (1982 to 1998) that both dramatize this violent process and propose an alternative through images of humans dislocated fromtheir bodies and fusing metaphysically with other open selves across space. Whereas critics have shown how global magic realist literatures use images of the non-unified self to represent the split consciousness resulting from colonial domination, my project explores how recent American texts religiously inflect such images and then through them imagine the transcendence of racial divisions. Challenging the notion of the human as a material isolate, images of the open body represent a literary vision for more expansive inter-racial identifications and more actively inclusive social solidarities for twenty-first century America.
Disulfide-stabilized trimeric hemagglutinin ectodomains provide enhanced heterologous influenza protection
Creators: name: Liu, De-Jian
name: Zhong, Xiu-Qin
name: Ru, Yan-Xia
name: Zhao, Shi-Long
name: Liu, Cui-Cui
name: Tang, Yi-Bo
name: Wu, Xuan
name: Zhang, Yi-Shuai
name: Zhang, Hui-Hui
name: She, Jia-Yue
name: Wan, Mu-Yang
name: Li, Yao-Wang
name: Zheng, He-Ping
name: Deng, Lei
Publisher: name: Taylor & Francis
Year: 2024
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology
subject: Computational Biology

description: Influenza virus infection poses a continual menace to public health. Here, we developed soluble trimeric HA ectodomain vaccines by establishing interprotomer disulfide bonds in the stem region, which effectively preserve the native antigenicity of stem epitopes. The stable trimeric H1 ectodomain proteins exhibited higher thermal stabilities in comparison with unmodified HAs and showed strong binding activities towards a panel of anti-stem cross-reactive antibodies that recognize either interprotomer or intraprotomer epitopes. Negative stain transmission electron microscopy (TEM) analysis revealed the stable trimer architecture of the interprotomer disulfide-stapled WA11#5, NC99#2, and FLD#1 proteins as well as the irregular aggregation of unmodified HA molecules. Immunizations of mice with those trimeric HA ectodomain vaccines formulated with incomplete Freund’s adjuvant elicited significantly more potent cross-neutralizing antibody responses and offered broader immuno-protection against lethal infections with heterologous influenza strains compared to unmodified HA proteins. Additionally, the findings of our study indicate that elevated levels of HA stem-specific antibody responses correlate with strengthened cross-protections. Our design strategy has proven effective in trimerizing HA ectodomains derived from both influenza A and B viruses, thereby providing a valuable reference for designing future influenza HA immunogens.
Breaking walls to build bridges
Creators: name: Mardari, Ghenadi
Publisher: name: No Publisher Supplied
Year: 2010

description: Public support for social policies or movements is often determined by intuitive considerations, perceived as matters of common sense. Existing theories interpret these dispositions in one of two ways: either as genetic traits inherited from hominid ancestors (evolutionary psychology), or as reified elements of cultural practices (social constructivism). Both of these approaches imply that common sense is local and context-dependent, without any primordial components. Nevertheless, rationality cannot emerge in material environments without a set of necessary beliefs. This means that common sense incorporates universal elements as well. By treating shared factual knowledge as subjective and the basic intuitions as objective (not the other way around), it is possible to understand the roots of cultural paradigms and the parameters that lead to their change over time. The interplay between belief and knowledge determines the type of principles that have the strongest appeal in any society. This process works at the level of the individual, especially in the early formative years, and shapes the generational transfer of values. Of special interest is the possibility of cultural change induced by advancements in science. For example, the social relevance of scientific rationality depends on the perceived compatibility between the necessary intuitions and the supported interpretations of physical phenomena. Global effects are possible in the long run, given the universality of relevant categories. Even the modern trend towards cultural fundamentalism can be reversed, assuming favorable conditions.   The goal of this dissertation is to provide a foundation for future research on the evolution of common sense. It is designed as an argument in three main steps. The first part aims to deduce the types of internal and external observables that determine the emergence of rational self-consciousness. The second part derives a limited list of physical properties that can be used to validate the ontological status of rationality. Those properties are shown to be compatible with existing empirical observations (but not with their interpretation) in the third part.   These conclusions suggest that the progress of democracy can be influenced by future scientific developments, especially through changes in the qualitative approaches to fundamental physical interactions.
Admission as submission
Creators: name: Rivera, Christopher
Publisher: name: No Publisher Supplied
Year: 2010

description: My dissertation is a study and contextualization of the three ethnic autobiographies of Chicano public intellectual Richard Rodriguez, The Hunger of Memory: The Education of Richard Rodriguez (1982), Days of Obligation: An Argument with my Mexican Father (1992), and Brown: The Last Discovery of America (2003).  Since the publication of Hunger of Memory, Rodriguez is identified as being against political programs like affirmative action or a “poster boy” for right-wing politics.  I argue for a more critical approach to Rodriguez’s controversial role in Chicana/o and Latina/o literary and cultural studies.  I explore the evolution of the author-protagonist, Richard, and highlight how his struggles are exemplary of postcolonial subjects negotiating their way through Americanization.  Assimilation produces psychosexual discourses that I analyze as particular to a colonized subject’s identity that is ambivalently positioned as at once typically American yet always outside the definition of what it means to be “authentically American.”  Building upon Octavio Paz’s “penetration paradigm” and expanding the implicit queer reading of la chingada and el rajado metaphors defined in Laberinto de la soledad (1950), my project articulates how the concepts of penetration, rejection, and ambivalence become strategies of resistance postcolonial subjects manipulate in pursuit of (in)authentic Americanism.    Spanning the U.S.-Mexican border, Rodriguez narrates the location the deviant, brown subject assumes in historical and present narratives of nation formation.  Rodriguez presents a colonized American subject who openly defends and explores various ambivalent processes of acculturation and assimilation.  Instead of adhering to Paz’s notion of impervious national masculinity, Rodriguez narrates his experiences as prototypical of the life of a deviant and dark subject who acknowledges the benefits and losses of openly admitting to inhabiting ambivalent locations in culture. Recognizing the relationship nations and individuals have with their ambivalence regarding penetration and rejection becomes crucial because admission is read as submission in the epistemology of penetration that my project delineates. Through close reading the autobiographies of Rodriguez, I identity a subtext of desire; it is a desire for memory, for the creation of alternative narratives and alternative spaces for postcolonial American life and subjectivity.