title: ÐÐ»Ð¸ÑÐ½Ð¸Ðµ ÑÐºÑÑÑÐ°ÐºÑÐ° ÐºÐ°ÑÐ¾ÑÐ¸Ð½Ð¾Ð¸Ð´Ð¾Ð² Ð¸Ð· Ð±Ð¸Ð¾Ð¼Ð°ÑÑÑ Ð²Ð¾Ð´Ð¾ÑÐ¾ÑÐ»ÐµÐ¹ Chlorella vulgaris Ð½Ð° Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð¾Ð¿ÑÑ Ð¾Ð»ÐµÐ²ÑÐµ ÑÑÑÐµÐºÑÑ Ñ Ð¼ÑÑÐµÐ¹ Ñ ÐºÐ°ÑÑÐ¸Ð½Ð¾Ð¼Ð¾Ð¹ Ð­ÑÐ»Ð¸Ñ Ð° Ð¿ÑÐ¸ Ð»ÐµÑÐµÐ½Ð¸Ð¸ ÑÐ¸ÑÐ¿Ð»Ð°ÑÐ¸Ð½Ð¾Ð¼
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÐ°
titleType: Subtitle
title: The effect of carotenoids extract from the biomass of Chlorella Vulgaris algae on antitumor effects in mice with Ehrlich's carcinoma treated with cisplatin
Creators: name: ÐÑÐ°Ð½Ð¸ÑÐ½Ð¸ÐºÐ¾Ð², ÐÐ»Ð°Ð´Ð¸ÑÐ»Ð°Ð²
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2022
Subjects: ÑÐ¸ÑÐ¿Ð»Ð°ÑÐ¸Ð½-Ð»ÑÐ½Ñ
Ð¼ÑÑÐ¸ BALB/c
Ð¾Ð¿ÑÑ Ð¾Ð»Ñ Ð­ÑÐ»Ð¸Ñ Ð°
Chlorella Vulgaris
Ð¾Ð½ÐºÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¸Ðµ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ñ
cisplatin-lance
BALB/c mice
Ehrlich tumor
oncological diseases

description: ÐÐ° 46 Ñ., 6 ÑÐ¸ÑÑÐ½ÐºÐ¾Ð², 8 ÑÐ°Ð±Ð»Ð¸Ñ.Ð­ÐºÑÑÑÐ°ÐºÑ ÐºÐ°ÑÐ¾ÑÐ¸Ð½Ð¾Ð¸Ð´Ð¾Ð² Ð¸Ð·Â Chlorella VulgarisÂ Ð¿Ð¾Ð»ÑÑÐµÐ½ Ð² Ð»Ð°Ð±Ð¾ÑÐ°ÑÐ¾ÑÐ¸Ð¸ ÐÑÑÑÐµÐ¹ ÑÐºÐ¾Ð»Ñ Ð±Ð¸Ð¾ÑÐµÑÐ½Ð¾Ð»Ð¾Ð³Ð¸Ð¸ Ð¸ Ð¿Ð¸ÑÐµÐ²ÑÑ Ð¿ÑÐ¾Ð¸Ð·Ð²Ð¾Ð´ÑÑÐ² Ð¡ÐÐ± ÐÐ¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑÐ° ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾.ÐÐ°Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð²Ð»Ð¸ÑÐ½Ð¸Ñ ÑÐºÑÑÑÐ°ÐºÑÐ° ÐºÐ°ÑÐ°ÑÐ¸Ð½Ð¾Ð¸Ð´Ð¾Ð² Ð½Ð° Ð¿ÑÐ¾ÑÐ¸Ð²Ð¾Ð¾Ð¿ÑÑÐ¾Ð»ÐµÐ²ÑÐ¹ ÑÑÑÐµÐºÑ Ð¿ÑÐ¸ Ð»ÐµÑÐµÐ½Ð¸Ð¸ ÑÐ¸ÑÐ¿Ð»Ð°ÑÐ¸Ð½Ð¾Ð¼. Ð Ð°ÑÑÐ¼Ð°ÑÑÐ¸Ð²Ð°Ð»Ð¸ÑÑ ÑÐ°ÐºÐ¸Ðµ Ð¿Ð¾ÐºÐ°Ð·Ð°ÑÐµÐ»Ð¸ ÐºÐ°Ðº Ð¸Ð½Ð´ÐµÐºÑ ÑÐ¾ÑÑÐ° Ð¾Ð¿ÑÑÐ¾Ð»Ð¸, Ð¾Ð±ÑÐµÐ¼ Ð¾Ð¿ÑÑÐ¾Ð»Ð¸, Ð¿Ð»Ð¾ÑÐ°Ð´Ñ Ð¿Ð¾Ð´ ÐºÐ¸Ð½ÐµÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÐºÑÐ¸Ð²Ð¾Ð¹ ÑÐ¾ÑÑÐ° Ð¾Ð¿ÑÑÐ¾Ð»Ð¸, Ð¼Ð°ÑÑÐ° ÑÐµÐ»Ð° Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÑ.ÐÐ»Ñ ÑÐµÑÐµÐ½Ð¸Ñ Ð¿Ð¾ÑÑÐ°Ð²Ð»ÐµÐ½Ð½Ð¾Ð¹ ÑÐµÐ»Ð¸ ÑÐµÑÐ°Ð»Ð¸ÑÑ Ð½Ð¸Ð¶ÐµÐ¿ÐµÑÐµÑÐ¸ÑÐ»ÐµÐ½Ð½ÑÐµ Ð·Ð°Ð´Ð°ÑÐ¸:- ÐÐµÑÐµÐ²Ð¸ÑÑ ÑÑÐ°Ð¼Ð¼ Ð¾Ð¿ÑÑÐ¾Ð»Ð¸ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÐ¼ Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÐ¼;- Ð Ð°Ð½Ð´Ð¾Ð¼Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°ÑÑ Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÑ Ñ Ð¿ÐµÑÐµÐ²Ð¸ÑÑÐ¼ ÑÑÐ°Ð¼Ð¼Ð¾Ð¼ Ð¾Ð¿ÑÑÐ¾Ð»Ð¸ Ð­ÑÐ»Ð¸ÑÐ° Ð½Ð° Ð³ÑÑÐ¿Ð¿Ñ;- ÐÑÐ¾Ð²ÐµÑÑÐ¸ Ð²ÑÐµ Ð½ÐµÐ¾Ð±ÑÐ¾Ð´Ð¸Ð¼ÑÐµ Ð¸Ð·Ð¼ÐµÑÐµÐ½Ð¸Ñ, ÑÐ°ÐºÐ¸Ðµ ÐºÐ°Ðº Ð¼Ð°ÑÑÐ° ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÑ Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÑ, Ð¾Ð±ÑÐµÐ¼ Ð¾Ð¿ÑÑÐ¾Ð»Ð¸, Ð¿Ð»Ð¾ÑÐ°Ð´Ñ Ð¿Ð¾Ð´ ÐºÐ¸Ð½ÐµÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÐºÑÐ¸Ð²Ð¾Ð¹;- ÐÑÐ¾Ð²ÐµÑÑÐ¸ Ð½ÐµÐ¾Ð±ÑÐ¾Ð´Ð¸Ð¼ÑÐµ ÑÐ°ÑÑÐµÑÑ;- ÐÑÐ¾Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°ÑÑ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÐµ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð¸ ÑÐ´ÐµÐ»Ð°ÑÑ Ð²ÑÐ²Ð¾Ð´ Ð¿Ð¾ Ð²ÑÐµÐ¹ ÑÐ°Ð±Ð¾ÑÐµ.ÐÐ±ÑÐµÐºÑÐ°Ð¼Ð¸ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð±ÑÐ»Ð¸ 4 Ð³ÑÑÐ¿Ð¿Ñ Ð¼ÑÑÐµÐ¹ Ñ Ð¿ÐµÑÐµÐ²Ð¸ÑÐ¾Ð¹ Ð¾Ð¿ÑÑÐ¾Ð»ÑÑ Ð­ÑÐ»Ð¸ÑÐ°.Ð­ÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½Ð¾-Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°ÑÐµÐ»ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿ÑÐ¾Ð²Ð¾Ð´Ð¸Ð»Ð°ÑÑ Ð² Ð½Ð°ÑÑÐ½Ð¾Ð¹ Ð»Ð°Ð±Ð¾ÑÐ°ÑÐ¾ÑÐ¸Ð¸ ÑÐ¸Ð¼Ð¸Ð¾Ð¿ÑÐ¾ÑÐ¸Ð»Ð°ÐºÑÐ¸ÐºÐ¸ ÑÐ°ÐºÐ° Ð¸ Ð¾Ð½ÐºÐ¾ÑÐ°ÑÐ¼Ð°ÐºÐ¾Ð»Ð¾Ð³Ð¸Ð¸ Ð¤ÐÐÐ£ Â«ÐÐÐÐ¦ Ð¾Ð½ÐºÐ¾Ð»Ð¾Ð³Ð¸Ð¸ Ð¸Ð¼. Ð. Ð. ÐÐµÑÑÐ¾Ð²Ð°Â» ÐÐ¸Ð½Ð·Ð´ÑÐ°Ð²Ð° Ð Ð¤.ÐÐ½Ð°Ð»Ð¸Ð·Ð¸ÑÑÐµÐ¼ÑÐ¼Ð¸ Ð¿Ð¾ÐºÐ°Ð·Ð°ÑÐµÐ»ÑÐ¼Ð¸ Ð±ÑÐ»Ð¸: Ð¸Ð½Ð´ÐµÐºÑ ÑÐ¾ÑÑÐ° Ð¾Ð¿ÑÑÐ¾Ð»Ð¸, Ð¾Ð±ÑÐµÐ¼ Ð¾Ð¿ÑÑÐ¾Ð»Ð¸, Ð¿Ð»Ð¾ÑÐ°Ð´Ñ Ð¿Ð¾Ð´ ÐºÐ¸Ð½ÐµÑÐ¸ÑÐµÑÐºÐ¾Ð¹ ÐºÑÐ¸Ð²Ð¾Ð¹ ÑÐ¾ÑÑÐ° Ð¾Ð¿ÑÑÐ¾Ð»Ð¸, Ð¼Ð°ÑÑÐ° ÑÐµÐ»Ð° Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÑ.Ð ÑÐ¾Ð´Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¹ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð½Ð¾, ÑÑÐ¾ ÑÐ¾Ð²Ð¼ÐµÑÑÐ½Ð¾Ðµ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¿ÑÐµÐ¿Ð°ÑÐ°ÑÐ° ÑÐ¸ÑÐ¿Ð»Ð°ÑÐ¸Ð½Ð° Ð¸ ÑÐºÑÑÑÐ°ÐºÑÐ° ÐºÐ°ÑÐ°ÑÐ¸Ð½Ð¾Ð¸Ð´Ð¾Ð² Ð¾ÐºÐ°Ð·ÑÐ²Ð°Ð»Ð¾ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ Ð½Ð° ÑÐ¾ÑÑ Ð¾Ð¿ÑÑÐ¾Ð»Ð¸ Ñ ÑÐºÑÐ¿ÐµÑÐ¸Ð¼ÐµÐ½ÑÐ°Ð»ÑÐ½ÑÑ Ð¶Ð¸Ð²Ð¾ÑÐ½ÑÑ Ð¸ Ð²ÑÐ·Ð²Ð°Ð»Ð¾ Ð·Ð°Ð¼ÐµÐ´Ð»ÐµÐ½Ð¸Ðµ ÐµÐµ ÑÐ¾ÑÑÐ°.
description: 46 pages, 6 figures, 8 tables.The extract of carotenoids fromÂ Chlorella VulgarisÂ was obtained in the laboratory of the Higher School of Biotechnology and Food Production of St. Petersburg Polytechnic University of Peter the Great.This work is devoted to the study of the effect of carotenoid extract on the antitumor effect in the treatment with cisplatin. Such indicators as tumor growth index, tumor volume, area under the kinetic curve of tumor growth, animal body weight were considered.To achieve this goal, the following tasks were solved:- Transfer the tumor strain to experimental animals;- Randomize animals with the transplanted strain of Ehrlich's tumor into groups;- Carry out all necessary measurements, such as the mass of experimental animals, the volume of the tumor, the area under the kinetic curve;- Make the necessary calculations;- Analyze the results obtained and draw a conclusion on the whole work.The objects of the study were 4 groups of mice with a transplanted Ehrlich tumor.Experimental research work was carried out in the scientific laboratory of Cancer Chemoprophylaxis and Oncopharmacology of the Federal State Budgetary Institution "N. N. Petrov" of the Ministry of Health of the Russian Federation.The analyzed indicators were tumor growth index, tumor volume, area under the kinetic curve of tumor growth, animal body weight.Studies have shown that the combined use of cisplatin and carotenoid extract had an effect on tumor growth in experimental animals and caused its growth to slow down.