cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Neurodegeneration induced by general anaesthetics in the developing brain: Mechanism and prevention
Creators: name: Shu, Yi
Publisher: name: Imperial College London
Year: 2010

description: In the early development of brain, there is an important period called the synaptogenesis period (also known as the brain growth-spurt period) which occurs in different mammalian species at different times relative to birth. In rodents, it begins a day or two before birth and ends 2 weeks after birth, whereas in humans it starts at the beginning of the third trimester and ends several years after birth. This is a critical period during neural development as neurons are establishing communications with their environment and other neurons to ensure that they develop and function appropriately; disruption at this stage by toxic agents including anaesthetic agents may compromise the normal neuronal development of the central nervous system. During the course of my PhD study, I found that inhalational agents isoflurane (ISO) alone or in combination with nitrous oxide (N2O) caused a wide spread neurodegeneration in the brain including the cingulated cortex, hippocampus, substantia nigra and basal forebrain in postnatal day 7 Sprague-Dawley rat pups. In those brain regions, the cells involved included glutamatergic, GABAergic and dopaminergic neurons. However, the cholinergic neurons in the basal forebrain were spared from anaesthesia-induced neuroapoptosis. My studies also showed that the neurodegeneration was not only confined to the higher centres, but was also observed in the spinal cord. These data indicated that the anaesthetics studied acted at molecular level and induced neuronal apoptosis by activating the intrinsic apoptotic pathway. It has been well documented that preconditioning with hypoxia or other interventions including pharmacological agents can protect against subsequent brain injury induced by hypoxia/ischemia. However, my data showed that hypoxic preconditioning exacerbated N2O+ISO-induced neonatal neurodegeneration, while xenon preconditioning protected against anaesthetics-induced neuroapoptosis and subsequent neurocognitve impairment. Most studies in this field including my own study described above are more relevant to the clinical situation where neonates are managed in the critical care unit, i.e. in the absence of surgery. For this reason, I implemented another experimental setting to mimic the clinical situation in the operating room where neonates receiving anaesthetic drugs are also subjected to nociceptive surgical stimuli. Therefore, in another experiment, rat pups in addition to receiving anaesthetic drugs were also subjected to standardised nociceptive stimuli. The results suggested that nociceptive stimuli enhanced neuronal apoptosis induced by anaesthetic drugs in the brain and the spinal cord and consequently impaired neurological function. Were the data reported in my thesis to be extrapolated to the clinical setting, it would have very important implications for the clinical management of paediatric population receiving general anaesthesia.
Development of Molecular Probes Responsive to Matrix Metalloproteinases
Creators: name: Cowell, Sheena
Publisher: name: Imperial College London
Year: 2013

description: Matrix metalloproteinases (MMPs) have been identified as biomarkers for cancer, offering prognostic potential. However, they lack non-invasive detection. This thesis highlights the work carried out on the design, synthesis and development of 19F MRI probes for the molecular imaging of MMP activity. The design of these MMP-activated imaging agents was based on the paramagnetic effects of gadolinium(III) on the NMR/MRI signal of a CF3 group in close proximity to the metal cation. 1st generation probes were prepared, incorporating MMP-2 selective peptide substrates SPAYYTA or SLAYYTA as a linker between gadolinium(III)-DOTA and Asp[(trifluoromethoxy)benzylamide]-OH. Attempts to monitor MMP-2 mediated peptide hydrolysis via HPLC and fluorescent assays proved problematic. The use of 68Ga and its complexation to DOTA provided a highly sensitive assay for the assessment of the peptide compounds. Using this method, assay conditions were optimised to observe on average 20% peptide cleavage over 2 hours with MMP-2, with selectivity observed against MMP-9 and MMP-14. The original gadolinium analogues of these compounds were then analysed by 19F NMR spectroscopy, successfully demonstrating a change in signal upon incubation with MMP-2. Development of the probes was then carried out to improve their clinical potential. Two pathways were explored; increasing compound reactivity through the introduction of spacer groups and increasing 19F sensitivity via increased local concentrations of fluorine, carried out utilising activated cell penetrating peptides (ACPPs). The latter method proved more successful, displaying similar reactivity and selectivity to 1st generation compounds. These ACPP probes are still in the early stages of development, with scope for future investigation. The transferability of 1st generation MMP-2-activated probes was also investigated via the production of a compound of analogous design, incorporating an MMP-14 selective substrate RIGFLR. Testing and development revealed this compound required incorporation of a two amino acid spacer group (SG) in order to demonstrate partial MMP-14 selectivity.
The Social Organization of Work Incapacity. Incapacities in the Swiss Social Insurance System and in the Workplace
Creators: name: Nadai, Eva
name: Gonon, Anna
name: Hübscher, Robin
name: John, Anna
Publisher: name: GESIS
Year: 2021
Subjects: subject: work incapacity
subject: social insurance
subject: valuation of labor
subject: sociology of conventions
subject: low-skilled workers
subject: 300 - Sozialwissenschaften, Soziologie, Anthropologie
subject: 360 - Soziale Probleme, Sozialdienste, Versicherungen

description: Arbeitsfähigkeit als unabdingbare Voraussetzung von Produktivität ist für die Wirtschaft und den Sozialstaat gleichermaßen ein zentrales Anliegen. Arbeitsunfähigkeit wirft daher die Frage nach sozialem Schutz für diejenigen auf, die als unproduktiv gelten. Auf der Basis zweier qualitativer Studien zur Beschäftigung von „behinderten“ respektive „unqualifizierten“ Arbeitskräften diskutieren wir die Regulierung von Arbeitsunfähigkeit im schweizerischen System der sozialen Sicherung. Am Beispiel der Invalidenversicherung wird aufgezeigt, wie Arbeitgeber Einfluss auf die Gestaltung sozialstaatlicher Institutionen nehmen, die dann als Formate in die Bewertung von Arbeitskraft eingehen. Sozialversicherungen und das Recht stellen zusammen mit betrieblichen Formaten Dispositive für die Bestimmung von Arbeits(un)fähigkeit und für Prüfungen der Qualität von Arbeitskräften dar. Sie eröffnen und begrenzen den Raum für die Tolerierung von verminderter Produktivität und für Kompromisse zwischen Qualitätskonventionen. Wenn gesundheitliche Einschränkungen und fehlende Qualifikationen kumulieren, führen die existierenden Formate eher zu Exklusion als zu Schutz.
Bacterial sensitivity and SOD behavior of N-pyrone glucosamine Schiff base Fe(III) complex: Conjoint experimental-DFT evaluation
Creators: name: Mir, Jan Mohammad
name: Rajak, Deepak Kumar
name: Maurya, Ram Charitra
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Iron and sugar are essential components of life processes. In the evident interest towards Fe(III) compounds to explore the ability of sugars towards metallotherapy, a systematic hyphenated DFT-experimental study of a novel sugar Schiff base Fe(III) complex of general composition [Fe(L)(OH)], where L = N-dehydroacetic acid-glucosamine (dha-glsH2), is presented. Based on various experimental spectrometric and spectroscopic characterization techniques in combination with theoretical data, a suitable distorted tetragonal structure is suggested for the complex. In addition to the formulation of the synthesized complex, superoxide dismutase (SOD) mimetic and antimicrobial actions have also been the active goal of the work. A promising superoxide dismutazing potential with IC50 = 69 μM was found. But on the other hand antibacterial action of the complex has shown less sensitivity to be called as efficient bactericidal agent.
Self-assembled nanocomplexes comprising of green tea catechin derivatives and protein drugs for cancer therapy
Creators: name: Tan, Susi
Publisher: name: Imperial College London
Year: 2013

description: The drug-to-carrier ratio has been a considerable issue in the design of a drug carrier, because the use of unreasonably high quantities of carrier can lead to problems associated with carrier toxicity, metabolism and elimination. However, if the carrier itself displays therapeutic effects, the drug-to-carrier ratio would no longer be a concern, and the delivery system should attain greater therapeutic effects from both the drug and the carrier. Epigallocatechin gallate (EGCG), a major ingredient of green tea, has been recognized as an attractive functional compound due to its various potential therapeutic effects, including anticancer effects. Herein we design the core-shell micellar nanocomplex (MNC) spontaneously constructed by self-assembly from the EGCG derivatives and proteins. This system achieved a greater anticancer effect in vitro and in vivo when loaded with an anticancer protein, as compared to the native protein or the carrier alone. This unique green tea-based MNC is the first nanoparticle drug delivery system that takes advantage of the beneficial bioactivities of EGCG.
title: Der gestielte ALT Lappen (anterolateral thigh flap) zur plastischen Deckung von ausgedehnten Gewebedefekten nach urologischen Eingriffen
Creators: name: Kalogirou, C.
name: Kocot, A.
name: Kübler, H.
name: Bernuth, S.
name: Jakubietz, R.
name: Jakubietz, M.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Fragestellung: Urologische Eingriffe - insbesondere in der Rezidivsituation nach mehrfachen Laparotomien oder bei der Fournier’schen Gangrän - können mitunter allschichtige Gewebedefekte in der Abdominal- und Genitalregion hinterlassen, welche sich mit konventionellen Verschiebelappenplastiken[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
Vitamin D receptor gene polymorphisms and risk of polycystic ovary syndrome in South Indian women
Creators: name: Siddamalla, Swapna
name: Tumu Venkat Reddy
name: Govatati, Suresh
name: Nagendram Erram
name: Mamata Deenadayal
name: Sisinthy Shivaji
name: Bhanoori, Manjula
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer

description: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of reproductive age women. Emerging evidence suggests that Vitamin D Receptor (VDR) might be a causal factor for characteristics associated with PCOS such as obesity and type 2 diabetes. Present study investigated association between VDR gene BsmI A/G (rs1544410), ApaI A/C (rs7975232) and TaqI T/C (rs731236) single nucleotide polymorphisms and PCOS risk in South Indian women. Genotyping of VDR gene SNPs was carried out in PCOS patients (n = 95) and controls (n = 130) by PCR-RFLP method and confirmed by sequencing analysis. Haplotype frequencies for multiple loci and the standardized disequilibrium coefficient (D′) for pairwise linkage disequilibrium (LD) were assessed by Haploview software. Results showed significantly increased frequencies of BsmI G/G (p = .0197), ApaI C/C (p = .048), TaqI C/C (p = .044) genotypes and BsmI G (p = .0181), ApaI C (p = .0092), TaqI C (p = .0066) alleles in patients compared to controls. In addition, the frequency of the ‘BsmI G, ApaI C, TaqI C’ haplotype was also significantly elevated in patients (p = .0087). In conclusion, the VDR gene BsmI A/G ApaI A/C TaqI T/C and haplotype may constitute an inheritable risk factor for PCOS in South Indian women.
title: A Benefit-Cost Analysis of Impact-Resistant Asphalt Shingle Roofing
Creators: name: Porter, Keith Alan
Publisher: name: Institute for Catastrophic Loss Reduction
Year: 2021

description: The Institute for Catastrophic Loss Reduction creates and disseminates disaster resilience knowledge for Canada. Among the catastrophes ICLR addresses are hailstorms, one of Canada’s most serious natural hazards. Hail costs $400 million annually. A June 2020 hailstorm at the edge of Calgary damaged 77,000 homes and cost $1.4 billion. Much of that money paid for roof repairs. A direct hit on Calgary could be 5 to 10 times worse. Though the hailstorm is inevitable, the catastrophe is not. This document summarizes a study of one way that homeowners and insurers can prevent costly hail damage: by using impact-resistant asphalt shingle roofs instead of standard shingles.

Impact-resistant roof shingles look like ordinary shingles, but have material that makes them resistant to hail damage. When struck by large hailstones, they resist pits and fractures that would otherwise allow water to pool or penetrate beneath them. And they resist cosmetic damage like the loss of granules: the specks that cover the shingle surface.
INNOVATIVE APPROACHES IN THE TREATMENT OF PATIENTS WITH DISSEMINATED PURULENT PERITONITIS
Creators: name: Sattarov, Shokir
name: Atoeva, Mokhigul
name: Usmonov, Amirbek
name: Saymurodova, Shaxnoza
Publisher: name: Zenodo
Year: 2024

description: Disseminated purulent peritonitis is associated with high mortality and significant difficulties in treatment [2, 6, 9, 11]. Purulent peritonitis is a severe, life-threatening condition that requires a comprehensive and timely approach to diagnosis and treatment. Despite modern advances in intensive care, surgical techniques and antibiotic therapy, mortality in widespread purulent peritonitis remains high [1, 3, 4, 7]. The development and implementation of an effective algorithm for the management of such patients is essential to improve treatment outcomes, reduce complications, and increase survival. Research in this area is necessary to optimise the treatment and diagnostic process and to form standards of medical care aimed at improving the quality of life of patients with this severe disease [5, 8, 10].
Operative and diagnostic strategies in pelvic floor disease and incontinence
Creators: name: Tan, Emile John Kwong-Wei
Publisher: name: Imperial College London
Year: 2012

description: Introduction: Pelvic floor disease affects many patients, with age, female gender and multiparity being significant associations. This can present clinically as pelvic organ prolapse, internal and external rectal mucosal intussuception, obstructed defecation syndrome, rectocele, cystocele and urinary/faecal incontinence. Diagnostic and treatment strategies for the management of such disorders is significantly varied, and evidence for current surgical management is poor. This thesis explores diagnostic and operative strategies currently regarded as state of the art and examines a novel method of pelvic floor assessment using MRI-based statistical shaped modelling. Methods: Meta-analysis in accordance with Cochrane collaboration guidelines was performed to assess laparoscopic versus open techniques for urinary incontinence, as well as endoanal ultrasound (EUS) scanning versus MRI in the assessment of faecal incontinence. The efficacy of sacral nerve stimulation (SNS) was reviewed. In addition, decision analysis was performed to assess the cost-effectiveness of delayed versus immediate anal sphincter repairs, and current operative treatments for end-stage faecal incontinence, and operative strategies for end-stage incontinence. MRI-based statistical shaped biomechanical modelling was performed to assess normal pelvic floors in comparison with patients with obstructed defecation syndrome. 15 asymptomatic volunteers aged 18 to 60 years were scanned and compared against 7 with obstructed defecation (ODS). Finally, 7 patients who were treated surgically for ODS were reassessed 6 months post-operation. Results: There were significant benefits to laparoscopic colposuspension for urinary incontinence. EUS was superior to MRI at detecting internal sphincter lesions, but not for external sphincter lesions. Immediate sphincter repairs were more cost-effective than delayed repairs. The artificial bowel sphincter and end stoma were more acceptable to both patient and institution than dynamic graciloplasty. Patients with obstructed defecation had significantly more irregular levator muscles with wider levator hiatus. Pressure during straining was concentrated in the posterior aspect of the hiatus, potentially contributing to the rectal neuropathy noted in obstructed defecation. Conclusions: Sacral nerve stimulation is an effective treatment for faecal incontinence. The artificial bowel sphincter and end stoma were cost-effective long-term strategies for end-stage faecal incontinence. A new technique for dynamic imaging and functionally assessing pelvic floor musculature has been developed and is showing promise as an adjunct to conventional assessment. Conventional defecating proctography does not provide the dynamic and functional assessment provided by this technique, and may translate well into a means of functional radiological assessment in the future.
title: Omentus Majus-Interponat und -Durchzug als Salvage-Operation bei komplexen vesiko-vaginalen Fisteln: Operative Technik und Langzeitergebnisse bei 25 Patientinnen
Creators: name: Panichi, R.
name: Kübler, H.
name: Riedmiller, H.
name: Kalogirou, C.
name: Kocot, A.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Fragestellung: Während in Entwicklungsländern vesiko-vaginale Fisteln (VVF) heutzutage vor allem als Folge von Geburtstraumata entstehen, sind diese in industrialisierten Ländern mit einer Inzidenz von 0,3-2% selten und treten hier meist als Folge von operativen Interventionen im[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
Advances in Neuromodulation for Bowel Dysfunction : Opening New Frontiers
Creators: name: George, Anil Thomas
Publisher: name: Imperial College London
Year: 2011

description: Neurostimulation in the form of sacral nerve stimulation has been used in the treatment of bowel dysfunction since the past 17-18 years. However, our knowledge on the alternative forms of neurostimulation such as pudendal nerve stimulation and posterior tibial nerve stimulation are limited. In addition, there exist several patient groups where sacral nerve stimulation is not effective. This thesis incorporates a series of studies done with the aim of expanding our existing knowledge on neurostimulation as well as exploring alternate forms of neurostimulation in treating bowel dysfunction. The role of pudendal nerve stimulation in faecal incontinence and the steps in the development of a new technique including cadaveric dissection, for stimulating the pudendal nerve are discussed. The new technique developed is subsequently used to successfully stimulate the pudendal nerve in two specific subgroups of patients where sacral nerve stimulation has not been effective in: patients with complete cauda equina syndrome and those who failed to improve with sacral nerve stimulation. The thesis explores additional routes of neurostimulation using the posterior tibial nerve and discusses the findings of a single blinded randomised placebo controlled clinical trial of percutaneous, transcutaneous and sham posterior tibial nerve stimulation in a group of faecal incontinent patients. Our knowledge on the effects of sacral nerve stimulation in constipation is relatively new. The results of a double blinded crossover study of sacral nerve stimulation in constipation sheds more light on the possible actions and effects of sacral nerve stimulation in this group of patients. The effects of sacral nerve stimulation in the elderly is discussed in the subsequent chapter through the presentation of the findings of a single center retrospective analysis on the safety and long term efficacy of sacral nerve stimulation in the elderly subgroup.
Hunger and learning : evidence on the costs and effectiveness of providing food through schools in food-insecure areas
Creators: name: Gelli, Aulo
Publisher: name: Imperial College London
Year: 2012

description: Globally, over the last decade primary school access has improved significantly. Yet challenges remain: 67 million primary school-aged children are not in school. Poor nutrition and health among schoolchildren are important barriers in achieving education-for-all goals. School feeding is a popular intervention supporting the education, health and nutrition of children in food-insecure settings. However, school feeding programmes are complex, involving a broad range of stakeholders across different sectors and implementation levels. This thesis is aimed at providing evidence to support policy-makers in managing trade-offs among alternative targeting approaches, feeding modalities, and costs. This work is also aimed at building an evidence-based framework to guide Governments in managing the inherent complexity of school feeding interventions. The thesis includes an analysis of a natural experiment involving survey data from 32 countries across sub-Saharan Africa that suggested that school feeding increased enrolment by 10 percent. Enrolment changes varied by modality and gender, with onsite meals having stronger effects in the first year of treatment in lower grades, and onsite combined with take-home rations being effective post-year 1, particularly for girls. Expenditures across 62 countries indicated considerable differences in costs across modalities, ranging from $23 USD for fortified biscuits to $75 USD for take-home rations. This raises important questions of cost-effectiveness and sustainability, also in terms of school-level costs not normally captured in programme expenditures. Findings also suggest that school level costs are substantive, and are a considerable overhead, considering that these costs are generally borne by food-insecure communities. The thesis also highlights that scaling-up school feeding requires significant financing, on average equal to 40 percent of primary education costs. Despite these opportunity costs there is strong buy-in on school feeding from governments in sub-Saharan Africa. The implications of this thesis also suggest that the complexity of school feeding as an intervention has perhaps been underestimated by policymakers. Strengthening the evidence linking outcomes to the design of school feeding and to the quality of the service delivery, including the trade-offs between implementation modalities, remains a critical area of future research. This thesis provides both a foundation and a step towards answering these complex questions in a comparable and meaningful way.
Frauen an die Spitze - dank neuen Arbeitsmodellen
Creators: name: Freiermuth, Karin
Publisher: name: Schweizerischer Gemeindeverband
Year: 2021
Subjects: subject: Gemeindeverwaltung
subject: Frauenförderung
subject: neue Arbeitsmodelle
subject: Teilzeit
subject: Jobsharing
subject: 350 - Öffentliche Verwaltung

description: Familienfreundliche Arbeitsmodelle in Gemeindeverwaltungen könnten helfen, dem Fachpersonalmangel entgegenzuwirken. In einigen Gemeinden hat man das erkannt und Gemeindeschreiberinnen in Teilzeitpensen oder im Jobsharing angestellt.
Study of immunomics and immune regulation in ovarian cancer
Creators: name: Abdul Aziz, Nor Haslinda
Publisher: name: Imperial College London
Year: 2013

description: Immunological suppression and regulation may be involved in tumour progression in many cancers. An integrated study has been carried out with regard to the protein expression of immune surface markers, soluble cytokines as well as the functional analysis of immune cells and their relationship to ovarian cancer and its prognosis. Peripheral blood, ascites, and tumour tissues were collected from patients with untreated ovarian cancers and benign ovarian tumours. Peripheral Blood Mononuclear Cells (PBMCs) from healthy women were used as a control. The immune cells that had been isolated for phenotypic analysis were analysed for immune surface and activation marker expressions using flow cytometry. Ovarian cancer tissues were used for immunohistochemistry (IHC) and for tissue RNA extraction to screen immune-related genes by quantitative real time PCR (qRT-PCR). Functional and enzymatic assays were performed to further characterise the regulatory and inhibitory molecules in the patients‟ PBMCs and ascites. It was found that the expression of regulatory T cells and T cell associated programmed death-1 molecule (PD-1) was significantly upregulated in cancer patients on the T cells. The programmed death ligand-1 (PD-L1) expression on monocytes from the patients‟ PBMCs and ascites was observed to have significantly increased in patients with ovarian cancer compared to women with benign diseases. From the functional results, it was hypothesised that PD-L1 may be involved in T cell dysfunction in ovarian cancer. The PBMCs, ascites, and tissues from ovarian cancer patients were also used to study the expression and potential role of immunomodulatory enzymes such as indoleamine 2,3-dioxygenase (IDO) and arginase in ovarian cancer.
Canada's Toughest Neighbourhood': Surveillance, Myth and Orientalism in Jane-Finch
Creators: name: Richardson, Chris
Publisher: name: Zenodo
Year: 2008
Subjects: toronto
jane finch
orientalism
surveillance

description: This study examines coverage of lane-Finch in popular Canadian newspapers in 2007. It explores the often-negative representations of the community through conceptual frameworks based on the work of Michel Foucault, Roland Barthes and Edward Said. The question it attempts to answer is: What knowledge and power relationships are embedded within depictions of lane-Finch in popular Canadian newspapers in 2007? The methodology is a version of critical discourse analysis based on Foucault's The Archaeology of Knowledge. It finds that predominantly-negative connotations of the neighbourhood are reinforced through the perpetuation of dominant discourses, the use of "expert" knowledge sources, and the discounting of subjugated knowledges or livedexperiences of residents. The study concludes by suggesting where further research within the realm of popular culture and community identity can be directed.
Disconnection, network dysfunction and cognitive impairment after traumatic brain injury
Creators: name: Bonnelle, Valerie
Publisher: name: Imperial College London
Year: 2012

description: It is now widely accepted that cognitive functions depend on the integrated operation of large-scale distributed brain networks. Recent methodological advances allow both structural and functional connectivity within these networks to be studied non-invasively in vivo. These approaches hold the promise of dramatically extending our understanding of the impact of traumatic brain injury (TBI) on cognition, which should help determine strategic targets for the rehabilitation of individuals with TBI. In this thesis, I present three studies that combine structural and functional magnetic resonance imaging to test the general hypothesis that cognitive deficits after TBI arise from structural disconnection within brain networks that mediate cognitive functions. In the first study, I demonstrate that sustained attention deficits in TBI patients are related to a failure to regulate activity within a ‘default-mode’ network (DMN) thought to be involved, among others, in internally directed processes such as self-referential thought. In addition, these deficits can be predicted by the functional and structural connectivity within the DMN. Next, I present a study investigating the neural basis for inhibitory control in healthy subjects using a modified version of the Stop Signal Task (SST). This study allows a clear distinction between attentional and response inhibition processes, and paves the way for my last study, which investigates inhibitory deficits after TBI. In this study, I demonstrate that a failure of DMN deactivation during response inhibition is associated with impaired inhibitory performance in TBI patients. The ability to efficiently regulate the DMN can be predicted by the structural integrity within a remote brain network previously proposed to be involved in switching between internally and externally directed attention. This work identifies DMN dysfunction as underlying various cognitive deficits after TBI, and confirms the relevance of white matter damage in the development of brain dysfunctions after TBI.
title: Perineale Blasenhalsrekonstruktion bei rezidivierender Blasenhalsenge nach Prostataoperationen
Creators: name: Dittrich, B.
name: Keller, H.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Fragestellung: Erfolgsrate der perinealen Blasenhalsrekonstruktion nach multiplen Therapieversuchen. Material/Methoden: Von 3/2006 - 9/ 2019 stellten sich insges. 33 Pat. zur plastischen Korrektur rez. Blasenhalsengen vor. Bei 7 (21%) im Z.n. TURP (Gruppe I) waren 4 Blasenhalsinzisionen/Resektionen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
Knowledge and Practice Changes Following a Student Data-Focused Data Management Education Program
Creators: name: Griffin, Tina
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: Uncategorized

description: Introduction: It is known that graduate students work with research data more intimately than their faculty mentors. Because of this, much data management education is geared toward this population. However, student learning has predominantly been assessed through measures of satisfaction and attendance rather than through evaluating knowledge and skills acquired. This study attempts to advance assessment efforts by asking students to report their knowledge and practice changes before, immediately after, and 6 months following education. Method: Graduate students in science, technology, engineering, and mathematics (STEM) and health science disciplines self-enrolled in an 8-week pilot data management program that used their research projects as the focus for learning. Three surveys were administered (pre-, post-, and 6 months following) to determine changes in students’ knowledge and practices regarding data management skills through self-assessment. The survey consisted of approximately 115 Likert-style questions and covered major aspects of the data life cycle. Results and Discussion: Overall, students increased their data management knowledge and improved their skills in all areas of the data life cycle. Students readily adopted practices for straightforward tasks such as determining storage and improving file naming. Students improved in but struggled with tasks that were more involved, such as sharing data and documenting code. For most of these practices, students consistently implemented them through the 6-month follow-up period. Conclusion: Impact of data management education lasts significantly beyond immediate instruction. In-depth assessment of student knowledge and practices indicates in which areas this education is effective and in which areas it needs further support. It is likely that this effect is due to the program length and focus on implementation.
Synthesising Nucleoside Analogues For Imaging Proliferation In Cancer And Other Biomedical Applications
Creators: name: Doepner, Andreas
Publisher: name: Imperial College London
Year: 2013

description: Rapidly proliferating cells, such as cancerous cells, show increased reliance on deoxyribonucleic acid (DNA) salvage pathways for producing nucleotides required for DNA synthesis. As such targeting these salvage pathways using radiolabelled nucleosides can provide a means of imaging the extent of proliferation within a tissue using positron emission tomography (PET). This permits the detection of malignant growths. Thiothymidine and 2’-deoxy-2’,2’-difluoro nucleoside analogues are currently being evaluated for theoretically superior properties in comparison to 3’-deoxy-3’-[18F]-fluorothymidine (FLT), the current standard PET proliferation marker. Investigations towards the design and synthesis of radiolabelled analogues of these nucleosides for evaluation as PET tracers were carried out. Synthesis and radiosynthesis of the 2’,2’-difluoro nucleoside analogue i was completed using a Stille coupling to introduce the carbon-11 radiolabel. The synthesis of ii, a precursor to a carbon-11 methylated gemcitabine analogue and iii, an intermediate in the synthesis of thiothymidine nucleosides are also reported. [Molecular diagram appears here. To view, please open pdf attachment] Based on the synthetic route developed for accessing iv an analogue of ii suitable for radiolabelling with fluorine-18, a series of difluoro nucleoside analogues with potential uses in PET, HIV therapy and fluorescent imaging were also synthesised v-viii. [Molecular diagram appears here. To view, please open pdf attachment]
Lernende setzen Fachbegriffe gezielt ein
Creators: name: Brunner, Pia
name: Pirani, Kathrin
Publisher: name: Beltz
Year: 2019
Subjects: subject: Luuise
subject: Unterrichtsentwicklung
subject: formative Selbstevaluation
subject: Lernen
subject: Fachbegriffe
subject: Chemieunterricht
subject: 370 - Erziehung, Schul- und Bildungswesen

description: Im Rahmen eines Luuise-Projekts bearbeitet eine Chemielehrerin im gymnnasialen Unterricht eine wiederkehrende Knacknuss erfolgreich.
Additional file 2 of An integrated strategy for deciding open versus laparoscopic hepatectomy for resectable primary liver cancer
Creators: name: Fu, Yizhen
name: Yang, Zhenyun
name: Hu, Zili
name: Yang, Zhoutian
name: Chen, Jinbin
name: Wang, Juncheng
name: Zhou, Zhongguo
name: Xu, Li
name: Chen, Minshan
name: Zhang, Yaojun
Publisher: name: figshare
Year: 2023
Subjects: Medicine
Cancer

description: Additional file 2: Table S1. Baseline Characteristics after PSM.
Self-assembled monolayers of Prussian blue nanoparticles with photothermal effect
Creators: name: Dacarro, Giacomo
name: Grisoli, Pietro
name: Borzenkov, Mykola
name: Milanese, Chiara
name: Fratini, Emiliano
name: Ferraro, Giovanni
name: Taglietti, Angelo
name: Piersandro Pallavicini
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: A photo-responsive antibacterial surface was prepared grafting non-toxic Prussian blue nanoparticles on a functionalized glass surface. Colloidal Prussian blue was synthesized as nanoparticles with cubic shape and grafted on a polyamine-functionalized SiO2 surface, obtaining a good coverage and a homogeneous distribution of the nanocubes. Irradiation of these samples in the so-called ‘bio-transparent window’ of the near-infrared allows to exert a triggered antibacterial effect.
Phase transition of a microemulsion upon addition of cyclodextrin – applications in drug delivery
Creators: name: Thakur, Sachin S.
name: Solloway, Jared
name: Stikkelman, Anneloes
name: Seyfoddin, Ali
name: Rupenthal, Ilva D.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Space Science
subject: Medicine
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Computational Biology

description: This study reports on the impact of cyclodextrin addition on the phase behavior of microemulsion systems. Three distinct oil-in-water microemulsions were formulated and subjected to increasing concentrations of various cyclodextrins. The prepared formulations underwent visual, textural and microscopic characterization followed by the evaluation of their in vitro drug release and ex vivo tissue retention behavior. Combining microemulsions with cyclodextrins resulted in either phase separation or transition into a liquid crystalline state depending on the concentration and type of cyclodextrin utilized. Formulations combined with α-cyclodextrin consistently demonstrated transition into a liquid crystalline state as confirmed by polarized light and cryo-scanning electron microscopy. In these cases, cyclodextrin addition was also positively correlated with an increase in formulation hardness, adhesiveness and turbidity. Release and clearance studies revealed that drug diffusion from the microemulsions could be slowed and tissue retention prolonged by increasing the cyclodextrin content. These findings pave the way for the development of novel cyclodextrin-microemulsion-based liquid crystalline formulations in a variety of sustained drug delivery applications.
IoT Cards for Predictive Food Rescue
Creators: name: Bedö, Viktor
name: Martins, Yann Patrick
name: Güngör, Ozan
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2023
Subjects: subject: food rescue
subject: experimental prototyping
subject: commoning-based predictive tech
subject: design toolkit
subject: 700 - Künste und Unterhaltung

description: The IoT Cards for Predictive Food Rescue explores specificities of commoning- and care-based data-driven infrastructure through the lens of prototyping cards. The cards were developed by an experimental design project investigating the predictive distribution of rescued food and the inherent friction between heterogenous situated cooking habits and city-wide infrastructure. The cards present themselves as a subversive extension pack for the IoT Service Kit, a third party open-source prototyping toolset for IoT service design.
Inhibition of human cytochromes P450 2A6 and 2A13 by flavonoids, acetylenic thiophenes and sesquiterpene lactones from Pluchea indica and Vernonia cinerea
Creators: name: Supattra Boonruang
name: Khanistha Prakobsri
name: Phisit Pouyfung
name: Ekaruth Srisook
name: Prasopthum, Aruna
name: Pornpimol Rongnoparut
name: Songklod Sarapusit
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The human liver cytochrome P450 (CYP) 2A6 and the respiratory CYP2A13 enzymes play role in nicotine metabolism and activation of tobacco-specific nitrosamine carcinogens. Inhibition of both enzymes could offer a strategy for smoking abstinence and decreased risks of respiratory diseases and lung cancer. In this study, activity-guided isolation identified four flavonoids 1–4 (apigenin, luteolin, chrysoeriol, quercetin) from Vernonia cinerea and Pluchea indica, four hirsutinolide-type sesquiterpene lactones 5–8 from V. cinerea, and acetylenic thiophenes 9–11 from P. indica that inhibited CYP2A6- and CYP2A13-mediated coumarin 7-hydroxylation. Flavonoids were most effective in inhibition against CYP2A6 and CYP2A13, followed by thiophenes, and hirsutinolides. Hirsutinolides and thiophenes exhibited mechanism-based inhibition and in irreversible mode against both enzymes. The inactivation kinetic KI values of hirsutinolides against CYP2A6 and CYP2A13 were 5.32–15.4 and 0.92–8.67 µM, respectively, while those of thiophenes were 0.11–1.01 and 0.67–0.97 µM, respectively.
Shaping aggregated load profiles based on optimized local scheduling of home appliances
Creators: name: Hunziker, Christoph
name: Schulz, Nicola
name: Wache, Holger
Publisher: name: Springer
Year: 2018
Subjects: subject: HEMS
subject: Real-time price
subject: Inclining block rates
subject: Demand response
subject: Distributed load management
subject: MILP
subject: 004 - Computer Wissenschaften, Internet
subject: 620 - Ingenieurwissenschaften und Maschinenbau

description: We present a new method to control an aggregated electric load profile by exploiting the flexibilities provided by residential homes. The method is based on a common energy price combined with inclining block rates, broadcasted to all households allowing them to minimize their energy provisioning cost. The distributed home energy management systems receive the price signal and use mixed integer linear programming for optimal scheduling of load, storage, and generation devices. The method provides excellent scalability as well as autonomy for home owners and avoids load synchronization effects. As proof of concept, an optimization algorithm for determining a day-ahead price is applied in two case studies. An excellent conformance between a given reference load profile and the resulting aggregated load profile of all households is demonstrated.
title: Intrapelvine prostatobulböse Harnröhrenanastomose nach membranösem Harnröhrenabriss und fehlgeschlager Rekonstruktion
Creators: name: Jelisejevas, L.
name: Rehder, P.
name: Gulacsi, A.
name: Pedrini, M.
name: Horninger, W.
name: Stühmeier, J.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Ziel: Harnröhrenrekonstruktion mit Erhalt der Kontinenz und Potenz. Fragestellung: Ist eine kontinenz-/potenzerhaltende Harnröhrenrekonstruktion nach komplexem Beckentrauma und fehlgeschlagener prostatabulböser Harnröhrenanastomose möglich? Methoden: Fallbericht[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 46. Gemeinsame Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie
Energieoptimiertes Data Center
Creators: name: Grüter, Cyrill
name: Gysel, Peter
name: Meier, Christoph
Publisher: name: Fachhochschule Nordwestschweiz FHNW
Year: 2011
Subjects: subject: Data Center
subject: Energieeffizienz
subject: Optimierung
subject: 004 - Computer Wissenschaften, Internet
subject: 624 - Ingenieurbau und Umwelttechnik

description: Die Effizienz eines Data Centers in Bezug auf dessen Energieverbrauch wird mit steigenden Energiekosten ein immer wichtigeres Thema. Das KTI-Projekt „Energie optimiertes Data Center“ befasst sich deshalb mit der mathematischen Modellierung des Energieverbrauchs eines Data Centers. Ziel des Projektes ist eine benutzerfreundliche Planungs- und Optimierungssoftware, welche mit Hilfe der entwickelten Modelle den Energieverbrauch eines Data Centers und dessen Teilsysteme berechnet. Unsere Software wird den Data Center Planern helfen, verschiedene Varianten von Data Centern zu planen und zu vergleichen, um dem Kunden die energieeffizienteste Lösung vorzuschlagen.
MOESM1 of Development of a novel, robust and cost-efficient process for valorizing dairy waste exemplified by ethanol production
Creators: name: Shen, Jing
name: Chen, Jun
name: Jensen, Peter
name: Solem, Christian
Publisher: name: figshare
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified
subject: Developmental Biology

description: Additional file 1. The genetic stability of JS93.
TEAMWORK AND PATIENT SAFETY IN SURGERY
Creators: name: Vats, Amit
Publisher: name: Imperial College London
Year: 2013

description: There is a growing concern that adverse events occur frequently in operating theatres. Adverse events such as wrong site surgery and surgical site infections have a severe detrimental impact on not only the patient but also the healthcare staff and the services. Institute of Medicine’s report, ‘To err is human’ highlighted that teamwork failures are a leading cause of death and suffering. Yet, in surgery, measuring teamwork and designing interventions to improve teamwork and patient safety in operating theatres remains an area of research that is largely unexplored. This thesis aims to measure and improve teamwork in operating theatres to ensure safer surgery. In this project, the WHO surgical safety checklist was evaluated for its impact on patient safety. The WHO checklist improved patient safety processes in operating theatres but its impact on teamwork, intra-operative problems and theatre efficiency was not clearly understood. Therefore, a framework was developed to measure teamwork failures, equipment problems and technical failures as surrogate markers of teamwork, patient safety and efficiency in operating theatres. Equipment failures emerged as a sensitive measure of teamwork in operating theatres. Teamwork failures were also associated with technical failures, delay in case progress and patient harm. It emerged that the WHO checklist can improve teamwork and theatre efficiency and reduce equipment problems in operating theatres when it is used in its true spirit rather than a tick-box exercise.