cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Scolia (Discolia) lateralis KLUG 1832
Creators: name: B, Cathimeris
name: B, Guigliana
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Scoliidae
Scolia
Scolia lateralis

description: Scolia (Discolia) lateralis KLUG, 1832
 Discolia lateralis (KLUG, 1832): WALKER 1871: 12 (Harkeko).
 Discolia lateralis (KLUG, 1832): INNES BEY 1911: 109 (Harkeko, catalogue Lord Collection). Scolia lateralis (KLUG, 1832) var.: GUIGLIA 1950b: 301 (taxonomy, Massawa (var.), Sabarguma). Scolia lateralis (KLUG, 1832) subsp. (?): GUIGLIA 1954: 344 (Harkeko).
D i s t r i b u t i o n: Harkeko, Massawa, Sabarguma.
 Scolia lateralis is known from the Afrotropical (Chad, Eritrea, Niger, Sudan) and Palaearctic regions.
description: Published as part of B, Cathimeris & B, Guigliana, 2021, A catalogue of the Scoliidae (Hymenoptera, Vespoidea) of Eritrea, pp. 743-750 in Linzer biologische Beiträge 53 (2) on page 747, DOI: 10.5281/zenodo.13154580
Analysis of multibunch free electron laser operation
Creators: name: Hellert, Thorsten
name: Decking, Winfried
name: Branlard, Julien
Publisher: name: Deutsches Elektronen-Synchrotron, DESY, Hamburg
Year: 2017
Subjects: subject: 530

description: At the SASE-FEL user facilities FLASH and European XFEL, superconducting TESLA type cavities are used for acceleration of the driving electron bunches. The high achievable duty cycle allows for operating with long bunch trains, hence considerably increasing the efficiency of the machine. However, multibunch free electron lasers (FEL) operation requires longitudinal and transverse stability within the bunch train. The purpose of this work is to investigate the intra-bunch-train transverse dynamics at FLASH and European XFEL. Key relationships of superconducting rf cavity operation and the resulting impact on the intrabunch-train trajectory variation are described. The observed trajectory variation during multibunch user runs at FLASH is analyzed and related to both, intrabunch-train variations of the rf and the following impact on the multibunch FEL performance.
Joinction de la Valserine au Rhône
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1785
Subjects: Schlucht

description: Blick in die Schlucht bei Bellegarde-sur-Valserine, wo die Valserine in die Rhone fliesst
description: dessiné d'apr. nat. [par Hans Conrad Escher von der Linth]
description: Auf der Rückseite dieses Blattes befindet sich die Zeichnung BRA 1785.0731
description: Beschriftungen im Bild: "Montagne à 2 l.", "côte [...]", "roches jeaune et noir", "roches", "roche noir", "chemin", "le Rhone agile", "Prex"
Boloria eunomia
Creators: name: Spitsyn, V. M.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Nymphalidae
Boloria
Boloria eunomia

description: Boloria eunomia (Esper, 1799)
 МатериаA. РОССИЯ: АрхангеΛьская обΛасть, Мезенский р-н, р. КойΔа, забоΛоченная тунΔра с реΔкими соснами, 66 ° 07'59"N, 42 ° 42'12"E, 16.06.2022, E. Spitsyna & V. Spitsyn leg. — 2♂; АрхангеΛьская обΛасть, Мезенский р-н, верховье р. КойΔа, верховое боΛото, 65 ° 56'10"N, 42 ° 26'50"E, 05.07.2022, E. Spitsyna & V. Spitsyn leg. — 1♂.
 Примечание. Первая нахоΔка ΔΛя Мезенского района и самая северная ΔΛя территории АрхангеΛьской обΛасти.
description: Published as part of Spitsyn, V. M., 2023, New records of Lepidoptera from the Arkhangelsk Region, Russia, pp. 261-266 in Amurian Zoological Journal XV (2) on page 262, DOI: 10.33910/2686-9519-2023-15-2-261-266, http://zenodo.org/record/12816741
Boloria euphrosyne
Creators: name: Spitsyn, V. M.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Nymphalidae
Boloria
Boloria euphrosyne

description: Boloria euphrosyne (Linnaeus, 1758)
 МатериаA. РОССИЯ: АрхангеΛьская обΛасть, Мезенский р-н, р. КойΔа, забоΛоченная тунΔра с реΔкими соснами, 66 ° 07'59"N, 42 ° 42'12"E, 16.06.2022, E. Spitsyna & V. Spitsyn leg. — 1♂; АрхангеΛьская обΛасть, Мезенский р-н, оз. КойΔа, верховое боΛото, 65 ° 57'16"N, 42 ° 26'17"E, 03.07.2022, E. Spitsyna & V. Spitsyn leg. — 2♀.
 Примечание. Первая нахоΔка ΔΛя Мезенского района и самая северная ΔΛя территории АрхангеΛьской обΛасти.
description: Published as part of Spitsyn, V. M., 2023, New records of Lepidoptera from the Arkhangelsk Region, Russia, pp. 261-266 in Amurian Zoological Journal XV (2) on page 263, DOI: 10.33910/2686-9519-2023-15-2-261-266, http://zenodo.org/record/12816741
Chûte d'eau prex de Magland
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1785
Subjects: Wasserfall

description: Die Zeichnung zeigt einen Wasserfall in der Nähe von Magland, umgeben von Felsen. Links unten ist eine kleine Hütte mit einem Wasserrad dargestellt
description: dessiné d'après nature [par Hans Conrad Escher von der Linth]
description: Auf der Rückseite dieses Blattes befindet sich die Zeichnung mit der Signatur "BRA 1785.0721"
description: Beschriftungen im Bild: "escarpements horizonteux", "irreguliers escarpent", "Escarpem irreguliers", "couvert d'arbriseaux", "Prex de Sable"
title: Modernes Cluster Management für Deep Learning Workloads
Creators: name: Villavicencio, Santiago
Publisher: name: Hochschule für Angewandte Wissenschaften Landshut
Year: 2024

description: Diese Bachelorarbeit untersucht die Herausforderungen und Lösungen bei der Verwaltung moderner Cluster, die durch hohe Anforderungen an Rechenleistung und Datenverarbeitung entstehen. In dieser Arbeit wird das Potenzial eines Deep-Learning Hardware-Management-Systems zur Verwaltung unserer lokalen Recheninfrastruktur untersucht: SkyPilot.

Die Studie zielt darauf ab, eine wartungsarme, hochflexible Lösung zu entwickeln, welche die Arbeitsabläufe der Forscherinnen und Forscher nur minimal beeinträchtigt, reibungslos von unseren Maschinen zu verschiedenen Rechnern in unserem Labor skaliert und moderne Tools wie das Accelerate-Paket von Huggingface und JAX unterstützt.

Die Lösung sollte auch große Grafikkarten-Speichersysteme für die Verfolgung der Workloads integrieren und die Sicherheit der Vorkaufsrechte für langlaufende Aufträge gewährleisten. Die Arbeit wird mit SkyPilot beginnen und darauf abzielen, dessen Funktionalität vor Ort zu implementieren.

Zu den erwarteten Ergebnissen gehört eine praktische Lösung für mindestens einen unserer lokalen Server und die einzelnen Maschinen in K017, welche den K017-Clustern bilden. Diese Lösung wird an mehreren großen Datensätzen von Huggingface demonstriert und soll sowohl mit lokalen als auch mit Cloud-basierten Clustern kompatibel sein.

Die Voraussetzungen für dieses Projekt umfassen einen kleinen Server, der als Testsystem zur Verfügung steht, sowie den Zugang zu allen Rechnern in K017 außerhalb der Vorlesungszeiten. Es wird erwartet, dass sich das Dokument im Laufe des Projekts weiterentwickelt, und bei Bedarf Klarstellungen und Anpassungen vorgenommen werden.
Scolia (Discolia) luteicornis
Creators: name: B, Cathimeris
name: B, Guigliana
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Scoliidae
Scolia
Scolia luteicornis

description: Scolia (Discolia) luteicornis (WALKER, 1871)
 Discolia luteicornis sp.n.: WALKER 1871: 13 (description ♁, Harkeko, Massawa).
 Scolia luteicornis (WALKER, 1871): DALLA TORRE 1897: 168 (taxonomy, world catalogue).
 Discolia luteicornis WALKER, 1871: INNES BEY 1911: 109 (Massawa, catalogue Lord Collection).
 Discolia luteicornis WALKER, 1871: MAGRETTI 1906: 10 (as Discolia luteipennis, biology, Massawa), 20 (Ailet).
 Scolia (Discolia) luteicornis (WALKER, 1871): BETREM & BRADLEY 1964: 92 (taxonomy, world catalogue).
 Scolia (Discolia) luteicornis (WALKER, 1871): OSTEN 2005: 37 (world catalogue).
D i s t r i b u t i o n: Ailet, Harkeko, Massawa.
 Scolia luteicornis is recorded also from Sudan.
description: Published as part of B, Cathimeris & B, Guigliana, 2021, A catalogue of the Scoliidae (Hymenoptera, Vespoidea) of Eritrea, pp. 743-750 in Linzer biologische Beiträge 53 (2) on pages 747-748, DOI: 10.5281/zenodo.13154580
Vue du glacier des bois prex du Montenvert
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1785
Subjects: Gletscher

description: Blick auf den Gletscher Mer de Glace von einem Ort in der Nähe des Aussichtspunktes Montenvers aus gesehen
description: déssiné d'après nature [par Hans Conrad Escher von der Linth]
description: Auf der Rückseite dieses Blattes befindet sich die Zeichnung BRA 1785.0805
description: Beschriftungen im Bild: "neige", "Sapins", "palissade"(?), "paturage"
Peer Review Workgroup Report
Creators: name: Barba, Lorena
name: Davenport, Nancy
name: Earle, Lacey
name: Gabriel, Ann
name: Newton, Mark
name: Packer, Abel
name: Price, Richard
Publisher: name: Open Scholarship Initiative Proceedings
Year: 2017

description: Building on the peer review workgroupâ€™s proposals from OSI2016, this workgroup will develop a broader and clearer description of peer review that considers the different needs for different stages of review, as well as discuss possibly emerging issues such as the need to promote uniform interpretation and enforcement of peer review definitions, and will develop proposals for moving forward.
description: Open Scholarship Initiative Proceedings, 2017
Boloria aquilonaris
Creators: name: Spitsyn, V. M.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Nymphalidae
Boloria
Boloria aquilonaris

description: Boloria aquilonaris (Stichel, 1908)
 МатериаA. РОССИЯ: АрхангеΛьская обΛасть, Мезенский р-н, с. КойΔа, тунΔра на берегу ручья, 66 ° 22'30"N, 42 ° 33'57"E, 12.07.2022, E. Spitsyna & V. Spitsyn leg. — 2♀; АрхангеΛьская обΛасть, Мезенский р-н, тунΔра, 66 ° 23'03"N, 42 ° 35'52"E, 13.07.2022, E. Spitsyna & V. Spitsyn leg. — 10♂; АрхангеΛьская обΛасть, Мезенский р-н, р. КойΔа, 66 ° 12'N, 42 ° 33'E, 15.07.2022, E. Spitsyna & V. Spitsyn leg. — 8♂, 2♀.
 Примечание. Первая нахоΔка ΔΛя Мезенского района и самая северная ΔΛя территории АрхангеΛьской обΛасти.
description: Published as part of Spitsyn, V. M., 2023, New records of Lepidoptera from the Arkhangelsk Region, Russia, pp. 261-266 in Amurian Zoological Journal XV (2) on page 263, DOI: 10.33910/2686-9519-2023-15-2-261-266, http://zenodo.org/record/12816741
Exploring the role of framework mutations in enabling breadth of a cross-reactive antibody (CR3022) against the SARS-CoV-2 RBD and its variants of concern
Creators: name: Saini, Samvedna
name: Agarwal, Manusmriti
name: Pradhan, Amartya
name: Pareek, Savitha
name: Singh, Ashish K
name: Dhawan, Gagan
name: Dhawan, Uma
name: Kumar, Yatender
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: Immunology
subject: FOS: Clinical medicine
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Cross-reactive and broadly neutralizing antibodies against surface proteins of diverse strains of rapidly evolving viral pathogens like SARS-CoV-2 can prevent infection and therefore are crucial for the development of effective universal vaccines. While antibodies typically incorporate mutations in their complementarity determining regions during affinity maturation, mutations in the framework regions have been reported as players in determining properties of broadly neutralizing antibodies against HIV and the Influenza virus. We propose an increase in the cross-reactive potential of CR3022 against the emerging SARS- CoV-2 variants of concern through enhanced conformational flexibility. In this study, we use molecular dynamics simulations, in silico mutagenesis, structural modeling, and docking to explore the role of light chain FWR mutations in CR3022, a SARS-CoV anti-spike (S)-protein antibody cross-reactive to the S-protein receptor binding domain of SARS-CoV-2. Our study shows that single substitutions in the light chain framework region of CR3022 with conserved epitopes across SARS-CoV strains allow targeting of diverse antibody epitope footprints that align with the epitopes of recently-categorized neutralizing antibody classes while enabling binding to more than one strain of SARS-CoV-2. Our study has implications for rapid and evolution-based engineering of broadly neutralizing antibodies and reaffirms the role of framework mutations in effective change of antibody orientation and conformation via improved flexibility. Communicated by Ramaswamy H. Sarma
Chamouni et le Glacier des Buissons
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1785

description: Blick auf Chamonix und den Glacier des Bossons im Hintergrund
description: dessiné d'ap. nat. [par Hans Conrad Escher von der Linth]
description: Auf der Rückseite dieses Blattes befindet sich die Zeichnung BRA 1785.0801
description: Beschriftungen im Bild: "nuage", "Glacier", "ex.", "prex", "sable", "Roc et Sapins", "Sapins", "Paturages rempli de Sapins", "arve"
The molecular docking and molecular dynamics study of flavonol synthase and flavonoid 3’-monooxygenase enzymes involved for the enrichment of kaempferol
Creators: name: Kumari, Garima
name: Nigam, Vinod Kumar
name: Pandey, Dev Mani
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biophysics
Biochemistry
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: Kaempferol is a natural flavonol that shows many pharmacological properties including anti-inflammatory, antioxidant, anticancer, antidiabetic activities etc. It has been reported in many vegetables, fruits, herbs and medicinal plants. The enzyme flavonol synthase (FLS, EC 1.14.20.6) catalyses the conversion of dihydroflavonols to flavonols. Whereas flavonoid 3’-monooxygenase (F3’H, EC 1.14.14.82) catalyses the hydroxylation of dihydroflavonol, and flavonol. FLS is involved in the synthesis of the kaempferol whereas F3’H causes degradation of kaempferol. The present study aimed to analyse the binding affinity, stability and activating activity of enzyme FLS as well as inhibitory activity of enzyme F3’H involved in the enrichment of the kaempferol using the in-silico approaches. Computational study for physico-chemical properties, conserved domain identification, 3-D structure prediction and its validation, conservation analysis, molecular docking followed by molecular dynamics analysis of FLS and F3’H, protein-activator (FLS-LIG Complex) and protein-inhibitor (F3’H-LIG Complex) complexes have been performed. Other structural analyses like root mean square fluctuation (RMSF), root mean square deviation (RMSD), surface area solvent accessibility (SASA), radius of gyration (Rg), hydrogen bond analysis, principal component analysis (PCA), Poisson-Boltzmann analysis (MM_PBSA) and the dynamic cross correlation map (DCCM) analysis to explore the structural, functional and thermodynamic stability of the proteins and the complexes were also studied. The molecular docking result showed that FLS binds strongly with the activator ascorbate (CID _54670067) while F3’H binds with the inhibitor ketoconazole (CID_456201). The most powerful inhibitor (ketoconazole for F3’H) and activator (ascorbate for FLS) is determined by computing the thermodynamic binding free energy through MM_PBSA analysis. The current work provides wide-ranging structural and functional information about FLS and F3’H enzymes showing detailed molecular mechanism of kaempferol biosynthesis and its degradation and hence kaempferol enrichment. Finding of the present work opens up new possibilities for future research towards enrichment of kaempferol by using activator (ascorbate) for FLS and inhibitor (ketoconazole) for F3’H as well as for its large-scale production using in vitro approaches. Communicated by Ramaswamy H. Sarma
In silico screening and in vitro validation of phytocompounds as multidrug efflux pump inhibitor against E. coli
Creators: name: Samreen
name: Qais, Faizan Abul
name: Ahmad, Iqbal
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: Multiple drug resistance (MDR) in bacteria has increased globally in recent times. This has reduced the efficacy of antibiotics and increasing the rate of therapeutic failure. Targeting efflux pump by natural and synthetic compounds is one of the strategies to develop an ideal broad-spectrum resistance-modifying agent. Very few inhibitors of AcrB from natural sources have been reported till date. In the current study, 19 phytocompounds were screened for efflux pump inhibitory activity against AcrB protein of E. coli TG1 using molecular docking studies. The molecular dynamics simulation provided stability the protein (AcrB) and its complex with chlorogenic acid under physiological conditions. Moreover, the detailed molecular insights of the binding were also explored. The Lipinski rule of 5 and the drug-likeness prediction was determined using Swiss ADME server, while toxicity prediction was done using admetSAR and PROTOX-II webservers. Chlorogenic acid showed the highest binding affinity (−9.1 kcal mol−1) with AcrB protein among all screened phytocompounds. Consequently, all the phytocompounds that accede to Lipinski’s rule, demonstrated a high LD50 value indicating that they are non-toxic except the phytocompound reserpine. Chlorogenic acid and capsaicin are filtered out based on the synergy with tetracycline having FIC index of 0.25 and 0.28. The percentage increase of EtBr fluorescence by chlorogenic acid was 36.6% followed by piperine (24.2%). Chlorogenic acid may be a promising efflux pump inhibitor that might be employed in combination therapy with tetracycline against E. coli, based on the above relationship between in silico screening and in vitro positive efflux inhibitory activity. Communicated by Ramaswamy H. Sarma.
Ville de Vevey depuis Plattet
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1785

description: des. d'a. n[ature] [par Hans Conrad Escher von der Linth]
description: Auf der Rückseite dieses Blattes befindet sich die Zeichnung BRA 1785.0810
description: Beschriftungen im Bild: "vignes"
Investigating the Conserved CTX-HaCaT Membrane Interaction and Secretome Alteration
Creators: name: YONG, YANNING
Publisher: name: Monash University
Year: 2024
Subjects: classificationCode: 320506
subject: Medical biochemistry - proteins and peptides (incl. medical proteomics)

description: Cobra bite-induced dermonecrosis is mainly caused by cytotoxin (CTX). Given the scarcity of effective treatments for dermonecrosis, it is crucial to have a better understanding of the role of CTX in dermonecrosis-associated envenomation. This study investigated the concentration of CTX as a determinant of cell death in human skin cells. We observed the interaction between CTX and the cell membrane using in silico and in vitro methods. The downstream pathways were elucidated via secretome analysis. We also identified a surface membrane protein, annexin A2, as a potential binding partner of CTX via cross-link mass spectrometry.
Ville de Vevey
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1785

description: dessinée d'ap. nat. [par Hans Conrad Escher von der Linth]
description: Auf der Rückseite dieses Blattes befindet sich die Zeichnung BRA 1785.0811
description: Beschriftungen im Bild: "St. Prex", "morges", "Coteau bien cultivé et garni d'arbres & de maisons", "vignes"
Euphydryas maturna
Creators: name: Spitsyn, V. M.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Nymphalidae
Euphydryas
Euphydryas maturna

description: Euphydryas maturna (Linnaeus, 1758)
 МатериаA. РОССИЯ: АрхангеΛьская обΛасть, Мезенский р-н, р. КойΔа, Λуг у реки, 66 ° 12'22"N, 42 ° 36'13"E, 16.06.2022, E. Spitsyna & V. Spitsyn leg. — 1♂; АрхангеΛьская обΛасть, Мезенский р-н, оз. КойΔа, верховое боΛото, 65 ° 57'16"N, 42 ° 26'17"E, 03.07.2022, E. Spitsyna & V. Spitsyn leg. — 1♀.
 Примечание. Первая нахоΔка ΔΛя Мезенского района и самая северная ΔΛя территории АрхангеΛьской обΛасти.
description: Published as part of Spitsyn, V. M., 2023, New records of Lepidoptera from the Arkhangelsk Region, Russia, pp. 261-266 in Amurian Zoological Journal XV (2) on page 263, DOI: 10.33910/2686-9519-2023-15-2-261-266, http://zenodo.org/record/12816741
Prospekt von der Kirche in Thun
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1785
Subjects: Thun
Berg
Gebirge

description: Blick vom Schlossberg in Thun auf das Aarebecken und den Thunersee, im Hintergrund die Berner Alpen
description: gezeichnet [von Hans Conrad Escher von der Linth]
description: Auf der Rückseite dieses Blattes befindet sich die Zeichnung BRA 1785.0825.2
Bioinformatic characterization of a triacylglycerol lipase produced by Aspergillus flavus isolated from the decaying seed of Cucumeropsis mannii
Creators: name: Ezema, Benjamin. O.
name: Omeje, Kingsley. O.
name: Bill, Roslyn M.
name: Goddard, Alan D.
name: Eze, Sabinus Oscar O.
name: Fernandez-Castane, Alfred
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biotechnology
subject: Evolutionary Biology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Virology

description: Lipases are enzymes of industrial importance responsible for the hydrolysis of ester bonds of triglycerides. A lipolytic fungus was isolated and subsequently identified based on the ITS sequence analysis as putative Aspergillus flavus with accession number LC424503. The gene coding for extracellular triacylglycerol lipase was isolated from Aspergillus flavus species, sequenced, and characterised using bioinformatics tools. An open reading frame of 420 amino acid sequence was obtained and designated as Aspergillus flavus lipase (AFL) sequence. Alignment of the amino acid sequence with other lipases revealed the presence GHSLG sequence which is the lipase consensus sequence Gly-X1-Ser-X2-Gly indicating that it a classical lipase. A catalytic active site lid domain composed of TYITDTIIDLS amino acids sequence was also revealed. This lid protects the active site, control the catalytic activity and substrate selectivity in lipases. The 3-Dimensional structural model shared 34.08% sequence identity with a lipase from Yarrowia lipolytica covering 272 amino acid residues of the template model. A search of the lipase engineering database using AFL sequence revealed that it belongs to the class GX-lipase, superfamily abH23 and homologous family abH23.02, molecular weight and isoelectric point values of 46.95 KDa and 5.7, respectively. N-glycosylation sites were predicted at residues 164, 236 and 333, with potentials of 0.7250, 0.7037 and 0.7048, respectively. O-glycosylation sites were predicted at residues 355, 358, 360 and 366. A signal sequence of 37 amino acids was revealed at the N-terminal of the polypeptide. This is a short peptide sequence that marks a protein for transport across the cell membrane and indicates that AFL is an extracellular lipase. The findings on the structural and molecular properties of Aspergillus flavus lipase in this work will be crucial in future studies aiming at engineering the enzyme for biotechnology applications. Communicated by Ramaswamy H. Sarma
Stadt Thun im Bern Gebiethe
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1785

description: Blick vom Aarebecken auf die Stadt Thun
description: nach der N. g. von Escher de K[efikon]
description: Auf der Rückseite dieses Blattes befindet sich die Zeichnung BRA 1785.0825.1
Scolia (Discolia) morio FABRICIUS 1781
Creators: name: B, Cathimeris
name: B, Guigliana
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Scoliidae
Scolia
Scolia morio

description: Scolia (Discolia) morio FABRICIUS, 1781
 Scolia morio FABRICIUS, 1781 ssp.: GUIGLIA 1958: 55 (taxonomy, Keren).
D i s t r i b u t i o n:Keren.
 Scolia morio, which is widely distributed in the Afrotropical region, is also known from Sudan.
description: Published as part of B, Cathimeris & B, Guigliana, 2021, A catalogue of the Scoliidae (Hymenoptera, Vespoidea) of Eritrea, pp. 743-750 in Linzer biologische Beiträge 53 (2) on page 748, DOI: 10.5281/zenodo.13154580
Sur la montagne de Zurich
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1786
Subjects: Zürich

description: Die Zeichnung zeigt Teile des Kreuzganges im ehemaligen "Klösterli", dem Chorherrenstift St. Martin auf dem Zürichberg
description: E[scher] des. d'ap. nat.
Hypoglycemic and hepatoprotective effects in adult zebrafish (Danio rerio) of fisetinidol isolated from Bauhinia pentandra: In vivo and in silico assays
Creators: name: da Silva, Horlando Carlota
name: de Oliveira Monteiro, Aurelio
name: de Queiroz Almeida-Neto, Francisco Wagner
name: Marinho, Emanuelle Machado
name: Ferreira, Maria Kueirislene Amâncio
name: da Silva Mendes, Francisco Rogênio
name: Marinho, Emmanuel Silva
name: Marinho, Márcia Machado
name: Bezerra, Lucas Lima
name: da Rocha, Matheus Nunes
name: de Menezes, Jane Eire Silva Alencar
name: Teixeira, Alexandre Magno Rodrigues
name: da Silva, Antonio Wlisses
name: de Lima Rebouças, Emanuela
name: Pinto, Francisco das Chagas Lima
name: dos Santos, Hélcio Silva
name: Santiago, Gilvandete Maria Pinheiro
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biochemistry
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified

description: Diabetes mellitus is a chronic metabolic disorder that has been increasing drastically around the worldwide. It is important to emphasize that although many drugs are commercially available to treat diabetes, many of them have shown a number of adverse effects. Therefore, search for new antidiabetic agents is of great interest, and natural products, especially those obtained from plants sources, may be an alternative to available drugs. This study reports the in vivo and in silico evaluation of the hypoglycemic activity of fisetinidol. The conformational analysis confirmed that the fisetinidol compound possesses two valleys in the potential energy curve, showing a stable conformer on the global minimum of the PES defined by the dihedral angle θ (C6-C7-O-H) at 179.9°, whose energy is equal to zero. In addition, fisetinidol has shown promise in glycemic control and oxidative stress caused by hyperglycemia induced by high sucrose concentration, causing hypoglycemic and hepatoprotective effects in adult zebrafish. ADMET studies showed that fisetinidol has high passive permeability, low clearance and low toxic risk by ingestion, and computational studies demonstrated that fisetinidol complexes in the same region as metformin and α-acarbose, which constitutes a strong indication that fisetinidol has the same inhibitory mechanisms of α-acarbose and metformin. Communicated by Ramaswamy H. Sarma.
Rapperschweil près du Lac de Zurich
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1786
Subjects: Steg

description: Rapperswil am Zürichsee mit dem alten, hölzernen Steg, im Hintergrund die Alpen
description: Escher des. d'ap. nat.
description: Vermerk oben rechts: "5."
Erebia disa
Creators: name: Spitsyn, V. M.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Nymphalidae
Erebia
Erebia disa

description: Erebia disa (Thunberg, 1791)
 Рис. 1: B
 МатериаA. РОССИЯ: АрхангеΛьская обΛасть, Мезенский р-н, с. КойΔа, тунΔра на берегу ручья, 66 ° 22'30"N, 42 ° 33'57"E, 23.06.2022, E. Spitsyna & V. Spitsyn leg. — 1♂; АрхангеΛьская обΛасть,Мезенский р-н, с. КойΔа, оз. Каменное, тунΔра с морошкой и карΛиковыми березками, 66 ° 21'28"N, 42 ° 31'14"E, 25.06.2022, E. Spitsyna & V. Spitsyn leg. — 4♂, 1♀.
 Примечание. Ранее виΔ быΛ известен по нахоΔке, сΔеΛанной боΛее ста Λет назаΔ в окрестностях гороΔа Мезень. (Kozlov et al. 2014). ЗΔесь мы поΔтвержΔаем обитание виΔа на территории АрхангеΛьской обΛасти. Вероятно, виΔ нужΔается в охране.
description: Published as part of Spitsyn, V. M., 2023, New records of Lepidoptera from the Arkhangelsk Region, Russia, pp. 261-266 in Amurian Zoological Journal XV (2) on page 263, DOI: 10.33910/2686-9519-2023-15-2-261-266, http://zenodo.org/record/12816741
Isle d'Ufenau dans le Lac de Zurich
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1786

description: E[scher] d. K[efikon] des. d'ap. nat
description: Beschriftungen im Bild: "Wiesen", "Lac"
description: Vermerk oben rechts: "6."
Computational investigation of the alkaloids of Pilocarpus microphyllus species as phytopharmaceuticals for the inhibition of sterol 14α-demethylase protease of Trypanosoma cruzi
Creators: name: de Sá, Ézio R. A.
name: Souza, Janilson L.
name: Costa, Rayla K. M.
name: Barros, Rômulo O.
name: de Lima, Carlos E. B.
name: Lima, Francisco das C. A.
name: Ramos, Ricardo M.
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Physical Sciences not elsewhere classified
subject: Medicine
subject: Molecular Biology
subject: Pharmacology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Biological Sciences not elsewhere classified

description: Trypanosoma cruzi is a protozoan transmitted by the insect Triatoma infestans, popularly known as kissing bug. This protozoan causes the Chagas disease, a Neglected Tropical Disease. This study aimed to investigate, through DFT method and B3LYP hybrid functional, the physicochemical, pharmacokinetic, and pharmacodynamic properties of the alkaloids present in the leaves of the species Pilocarpus microphyllus (jaborandi) as a potential inhibitory activity on the protease sterol 14α-demethylase of T. cruzi associated with the techniques of molecular docking, molecular dynamics, MM-PBSA and ADMET predictions. The molecules of isopilosine, epiisopiloturine, epiisopilosine, and pilosine showed up the lowest binding energies by molecular docking, good human intestinal absorption, low penetration in the blood-brain barrier, antiprotozoal and anticarcinogenic activities in ADMET studies. It has been observed a better binding affinity of the sterol 14α-demethylase protease with isopilosine in molecular dynamics and MM-PBSA studies, which indicates it as a potential drug candidate for Chagas disease. Communicated by Ramaswamy H. Sarma
Erebia euryale
Creators: name: Spitsyn, V. M.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Nymphalidae
Erebia
Erebia euryale

description: Erebia euryale (Esper, 1805)
 МатериаA. РОССИЯ: АрхангеΛьская обΛасть, Мезенский р-н, с. КойΔа, тунΔра на берегу ручья, 66 ° 22'30"N, 42 ° 33'57"E, 12.07.2022, E. Spitsyna & V. Spitsyn leg. — 6♂, 2♀; АрхангеΛьская обΛасть, Мезенский р-н, тунΔра, 66 ° 23'03"N, 42 ° 35'52"E, 13.07.2022, E. Spitsyna & V. Spitsyn leg. — 9♂, 3♀; АрхангеΛьская обΛасть, Мезенский р-н, р. КойΔа, 66 ° 12'N, 42 ° 33'E, 15.07.2022, E. Spitsyna & V. Spitsyn leg. — 2♂, 3♀.
 Примечание. Первая нахоΔка ΔΛя Мезенского района и самая северная ΔΛя территории АрхангеΛьской обΛасти.
description: Published as part of Spitsyn, V. M., 2023, New records of Lepidoptera from the Arkhangelsk Region, Russia, pp. 261-266 in Amurian Zoological Journal XV (2) on page 263, DOI: 10.33910/2686-9519-2023-15-2-261-266, http://zenodo.org/record/12816741
An Efficient HTN to STRIPS Encoding for Concurrent Plans
Creators: name: Cavrel, N.
name: Pellier, D.
name: Fiorino, H.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: The Hierarchical Task Network (HTN) formalism is used to express a wide variety of planning problems in terms of decompositions of tasks into subtaks. Many techniques have been proposed to solve such hierarchical planning problems. A particular technique is to encode hierarchical planning problems as classical STRIPS planning problems. One advantage of this technique is to benefit directly from the constant improvements made by STRIPS planners. However, there are still few effective and expressive encodings. In this paper, we present a new HTN to STRIPS encoding allowing to generate concurrent plans. We show experimentally that this encoding outperforms previous approaches on hierarchical IPC benchmarks.
Evaluation of glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism and susceptibility to type 2 diabetes mellitus, a meta-analysis
Creators: name: Saadat, Mostafa
Publisher: name: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
Year: 2017
Subjects: susceptibility
heterogeneity
risk
Diabetes mellitus
genetic polymorphism

description: It is well established that type 2 diabetes mellitus (T2DM) is associated with oxidative stress and glutathione S-transferases (GSTs) protect cells against oxidative stress. The missense substitution Ile105Val (rs1695) of the glutathione S-transferase P1 (GSTP1, OMIM: 134660) results from an A/G base substitution at nucleotide 313. Many studies have evaluated the correlation between the rs1695 polymorphism and T2DM, but the results remain inconclusive. The aim of the present meta-analysis was to investigate the association between GSTP1 Ile105Val polymorphism and the susceptibility risk of T2DM. Eligible studies (published before August 2017) were identified in several databases. The heterogeneity between studies was evaluated with the chi-square based Q test and the I2 test. The strengths of the association were assessed by pooled odds ratios (ORs) and the corresponding 95 % confidence interval (95 % CI) using either a fixed or random-effects models. Eighteen studies documenting a total of 2595 T2DM cases and 2888 controls were included in this meta-analysis. In the overall analysis there was no significant association between the rs1695 polymorphism and the risk of T2DM. The subgroup analyses stratified by ethnicity, publication year and sample size did not reveal significant association between the study polymorphism and the risk of T2DM and any sources contributing to the substantial heterogeneity between studies. The present meta-analysis suggested that there was significant heterogeneity between studies. Considering some limi tations of our meta-analysis, further large-scale studies should be done to reach a more comprehensive understanding.
description: EXCLI Journal; 16:Doc1188; ISSN 1611-2156
Scrapter divergens
Creators: name: Kuhlmann, Michael
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Colletidae
Scrapter
Scrapter divergens

description: Scrapter divergens (FRIESE, 1925)spec. rev.
 Polyglossa (Strandiella) divergens FRIESE, 1925: 515. Holotype ♀ (Willowmore, South Africa) (ZMHB), examined.
 EARDLEY (1996) synonymised this species with S. ruficornis (Cockerell).
description: Published as part of Kuhlmann, Michael, 2021, Taxonomic notes on the bee genus Scrapter LEPELETIER & SERVILLE, 1828, with a checklist to species (Hymenoptera, Anthophila, Colletidae), pp. 699-714 in Linzer biologische Beiträge 53 (2) on page 701, DOI: 10.5281/zenodo.13154583
Diversity and Inclusion Statement NumPy for Chan Zuckerberg Initiative EOSS 2019 round 1
Creators: name: Gommers, Ralf
Publisher: name: figshare
Year: 2020
Subjects: subject: 80306 Open Software
subject: FOS: Computer and information sciences

description: This diversity statement was part of the grant proposal for NumPy and OpenBLAS that was submitted to round 1 of the Essential Open Source Software for Science program from the Chan Zuckerberg Initiative in July 2019.

For more details, see:

- The proposal: https://figshare.com/articles/journal_contribution/Proposal_NumPy_OpenBLAS_for_Chan_Zuckerberg_Initiative_EOSS_2019_round_1/10302167
- RFA: https://chanzuckerberg.com/rfa/essential-open-source-software-for-science/- blog post from the program managers: https://medium.com/@cziscience/the-invisible-foundations-of-biomedicine-4ab7f8d4f5dd- press release from the Chan Zuckerberg Initiative: https://chanzuckerberg.com/newsroom/chan-zuckerberg-initiative-awards-5-million-for-open-source-software-projects-essential-to-science/
Oeneis jutta
Creators: name: Spitsyn, V. M.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Nymphalidae
Oeneis
Oeneis jutta

description: Oeneis jutta (Hubner, 1806)
 МатериаA. РОССИЯ: АрхангеΛьская обΛасть, Мезенский р-н, р. КойΔа, забоΛоченная тунΔра с реΔкими соснами, 66 ° 07'59"N, 42 ° 42'12"E, 16.06.2022, E. Spitsyna & V. Spitsyn leg. — 1♂.
 Примечание. Первая нахоΔка ΔΛя Мезенского района и самая северная ΔΛя территории АрхангеΛьской обΛасти. Вероятно, виΔ нужΔается в охране.
description: Published as part of Spitsyn, V. M., 2023, New records of Lepidoptera from the Arkhangelsk Region, Russia, pp. 261-266 in Amurian Zoological Journal XV (2) on page 263, DOI: 10.33910/2686-9519-2023-15-2-261-266, http://zenodo.org/record/12816741
Ici repose l'homme de la nature et de la verité
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1786
Subjects: Grab
Temple de la philosophie
Rousseau, Jean-Jacques1712-1778

description: Das Grab von Jean-Jacques Rousseau auf der Pappelinsel (Île des peupliers) im Schlosspark Ermenonville
description: dessiné d'ap. nat. par J.C. Escher de Keffiken
Barque du Brabant
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1787
Subjects: Handelsschiff

description: Holländisches Handelsschiff
description: [Hans Conrad Escher von der Linth]
description: Beschriftung im Bild: "marchandises"
description: Die Zeichnung wurde unregelmässig, möglicherweise aus einem Reisebericht ausgeschnitten. Auf dem Verso befinden sich handschriftliche Notizen Eschers auf Französisch (mit grossen, gitterartigen Linien durchgestrichen)
In silico screening and in vitro validation of phytocompounds as multidrug efflux pump inhibitor against E. coli
Creators: name: Samreen
name: Qais, Faizan Abul
name: Ahmad, Iqbal
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Information Systems not elsewhere classified

description: Multiple drug resistance (MDR) in bacteria has increased globally in recent times. This has reduced the efficacy of antibiotics and increasing the rate of therapeutic failure. Targeting efflux pump by natural and synthetic compounds is one of the strategies to develop an ideal broad-spectrum resistance-modifying agent. Very few inhibitors of AcrB from natural sources have been reported till date. In the current study, 19 phytocompounds were screened for efflux pump inhibitory activity against AcrB protein of E. coli TG1 using molecular docking studies. The molecular dynamics simulation provided stability the protein (AcrB) and its complex with chlorogenic acid under physiological conditions. Moreover, the detailed molecular insights of the binding were also explored. The Lipinski rule of 5 and the drug-likeness prediction was determined using Swiss ADME server, while toxicity prediction was done using admetSAR and PROTOX-II webservers. Chlorogenic acid showed the highest binding affinity (−9.1 kcal mol−1) with AcrB protein among all screened phytocompounds. Consequently, all the phytocompounds that accede to Lipinski’s rule, demonstrated a high LD50 value indicating that they are non-toxic except the phytocompound reserpine. Chlorogenic acid and capsaicin are filtered out based on the synergy with tetracycline having FIC index of 0.25 and 0.28. The percentage increase of EtBr fluorescence by chlorogenic acid was 36.6% followed by piperine (24.2%). Chlorogenic acid may be a promising efflux pump inhibitor that might be employed in combination therapy with tetracycline against E. coli, based on the above relationship between in silico screening and in vitro positive efflux inhibitory activity. Communicated by Ramaswamy H. Sarma.
From Gene Repression to the Maintenance of Facultative Heterochromatin: A Molecular Basis
Creators: name: MURRAY, MELANIE
Publisher: name: Monash University
Year: 2024
Subjects: classificationCode: 310504
subject: Epigenetics (incl. genome methylation and epigenomics)

description: Repressive histone methyltransferases maintain genes in a repressed state and are required for the normal development of metazoan species. Previous evidence suggested that repressive transcription factors bind to repressive histone methyltransferases to recruit them to chromatin, but such interactions could not be detected here. Instead, physical interactions were mapped between other chromatin-associated factors and histone methyltransferases using various biophysical approaches. Additionally, using reconstituted systems and in vitro enzymatic assays, this thesis highlights how regulatory factors affect the chromatin-modification activity of repressive histone methyltransferase. Overall, this thesis provides insights into multifactorial mechanisms responsible for maintaining the repressed state of genes.
Synthesis, molecular docking, molecular dynamics and evaluation of Drug-Likeness properties of the fused N-Formyl pyrazoline substituted new dehydroepiandrosterone derivatives
Creators: name: Çapan, İrfan
name: Shehu, Abdulmalik
name: Sert, Yusuf
name: Çelik, İsmail
name: Erol, Meryem
name: Koca, İrfan
name: Servi, Süleyman
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biophysics
subject: Biochemistry
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Chemical Sciences not elsewhere classified
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Cancer

description: The hybrid molecules bearing heterocyclic structures in the A or D rings of steroids have significant biological activity. 16 (E)-Hetereoarylidene steroids were synthesized from the reaction of different heteroaromatic carbaldehydes and trans-Dehydroepiandrosterone (DHEA) in a basic medium. Then, synthesis of the N-formyl pyrazoline substituted new DHEA derivatives were carried out from the reaction of hydrazine hydrate and 16 (E)-hetereoarylidene steroids. The structures of the synthesized compounds were elucidated by elemental analysis, FT-IR, 1H NMR, and 13C NMR spectroscopy. To investigate the activation pathway of synthesized N-formyl pyrazoline substituted steroid derivatives, a molecular docking study was performed on human cytochrome P450-(CYP17A1: PDB ID 5IRQ) with the help of the free AutoDock Vina. 100 ns molecular dynamic simulation process was performed to monitor the behavior of the complex structure formed by CYP17A1 and to calculate the stability over time of 2a and 2d (-9.8 kcal/mol), which gave the lowest value according to the results obtained in the molecular docking study with AutoDock Vina. Accordingly, RMSD, RMSF, Rg, and SASA analyzes of 2a and 2d were performed, and MMPBSA was calculated. Lastly, the ADMET (absorption, distribution, metabolism, excretion, and toxicity) analyses of the novel steroid derivatives were investigated. Communicated by Ramaswamy H. Sarma
[Treidelschiff]
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1787
Subjects: Handelsschiff
Treideln

description: Die Skizze zeigt einen Fluss oder Kanal, auf dem ein Handelsschiff von Pferden auf beiden Ufern gezogen wird, zwei Staffagefiguren im Vordergrund
description: [Hans Conrad Escher von der Linth]
description: Vgl. die Zeichnung BRA 1787.001 mit dem selben Handelsschiff
Macroglossum stellatarum
Creators: name: Spitsyn, V. M.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Lepidoptera
Sphingidae
Macroglossum
Macroglossum stellatarum

description: Macroglossum stellatarum (Linnaeus, 1758) Рис. 1: C
 МатериаA. РОССИЯ: АрхангеΛьская обΛасть, Мезенский р-н, мыс Воронов, 13.06.2022, A. Malygin leg. — 1♂.
 Примечание. Мигрант. Первая нахоΔка ΔΛя Мезенского района и самая северная нахоΔка ΔΛя виΔа.
description: Published as part of Spitsyn, V. M., 2023, New records of Lepidoptera from the Arkhangelsk Region, Russia, pp. 261-266 in Amurian Zoological Journal XV (2) on page 263, DOI: 10.33910/2686-9519-2023-15-2-261-266, http://zenodo.org/record/12816741
Scrapter flavitarsis COCKERELL 1936
Creators: name: Kuhlmann, Michael
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Colletidae
Scrapter
Scrapter flavitarsis

description: Scrapter flavitarsis COCKERELL, 1936spec. rev.
 Scrapter flavitarsis COCKERELL, 1936b: 481. Lectotype ♁ [designated by EARDLEY 1996] (Cape Town, South Africa) (NHML), examined.
 EARDLEY (1996) synonymised this species with S. opacus (FRIESE).
description: Published as part of Kuhlmann, Michael, 2021, Taxonomic notes on the bee genus Scrapter LEPELETIER & SERVILLE, 1828, with a checklist to species (Hymenoptera, Anthophila, Colletidae), pp. 699-714 in Linzer biologische Beiträge 53 (2) on page 701, DOI: 10.5281/zenodo.13154583
Combining Counterfactuals With Shapley Values To Explain Image Models
Creators: name: Lahiri, Aditya
name: Alipour, Kamran
name: Adeli, Ehsan
name: Salimi, Babak
Publisher: name: arXiv
Year: 2022
Subjects: subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: With the widespread use of sophisticated machine learning models in sensitive applications, understanding their decision-making has become an essential task. Models trained on tabular data have witnessed significant progress in explanations of their underlying decision making processes by virtue of having a small number of discrete features. However, applying these methods to high-dimensional inputs such as images is not a trivial task. Images are composed of pixels at an atomic level and do not carry any interpretability by themselves. In this work, we seek to use annotated high-level interpretable features of images to provide explanations. We leverage the Shapley value framework from Game Theory, which has garnered wide acceptance in general XAI problems. By developing a pipeline to generate counterfactuals and subsequently using it to estimate Shapley values, we obtain contrastive and interpretable explanations with strong axiomatic guarantees.
Sonnenstein près de Dresden
Creators: name: Escher von der Linth, Hans Konrad
Publisher: name: [s.n.]
Year: 1787
Subjects: Pirna

description: des. d'ap. nat. ... p. J.C. E[scher] d. K[efikon]
description: Beschriftungen im Bild: "champs jaune", "elbe fleuve", "champs [...] d'un beau[...]", "brun", "chemin", "herbes jeaunes", " le 4. octob."