Zn (II) complex with vanillin derived Schiff base: antifungal, antibacterial, antioxidant and anticholinesterase activities
Creators: name: de Oliveira Pinheiro, Solange
name: Braga, Jordana Lima
name: da Silva, Wildson Max Barbosa
name: Do Nascimento, Guida Hellen Mota
name: Montes, Renato Almeida
name: Alves, Daniela Ribeiro
name: Rodrigues, Daniel Sampaio
name: Leitão, Amanda Cavalcante
name: de Farias Cabral, Vitória Pessoa
name: Moreira, Lara Elloyse Almeida
name: Do Amaral Valente Sá, Lívia Gurgel
name: da Silva, Cecília Rocha
name: de Andrade Neto, João Batista
name: Canuto, Kirley Marques
name: de Morais, Selene Maia
name: Júnior, Hélio Vitoriano Nobre
Publisher: name: Taylor & Francis
Year: 2025
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified

description: To synthesize and characterize a Schiff base derived from vanillin and tris(hydroxymethyl)aminomethane (VTRIS) and the Zinc (II) complex [Zn(VTRIS)<sub>2</sub>](CH<sub>3</sub>COO)<sub>2</sub>. VTRIS and the Zn (II) complex were synthesized through condensation and complexation reactions, respectively. Structures were confirmed by electron spectroscopy in the UV-Vis, FT-IR and NMR regions. Toxicity was evaluated in Artemia salina, antimicrobial activity was evaluated by microdilution assay, ABTS and DPPH methods were used for antioxidant effect and the anticholinesterase potential was investigated. VTRIS and the complex showed low toxicity in <i>Artemia salina</i> (LC<sub>50</sub> = 698.56 and 543.88, respectively). VTRIS did not show antifungal or antibacterial activity, but the complex showed MICs ranging from 32 to 128 μg/mL against <i>Cryptococcus neoformans</i> and <i>Candida</i> spp. and 512 μg/mL against <i>Staphylococcus aureus</i>, demonstrating an antimicrobial effect improvement after coordination to the metal center. VTRIS and the complex showed excellent results as antioxidant molecules, and the complex presented lower values than the standard quercetin in the ABTS method (IC<sub>50</sub> = 1.08 and 1.63 μg/mL, respectively). VTRIS and the complex showed anticholinesterase potential of 1.93 and 1.83 μg/mL. Zn complexation potentiates VTRIS, and this compound exhibits promising antimicrobial, antioxidant, and anticholinesterase activities at nontoxic concentrations. The number of novel medicines launched on the market is decreasing over the years, making the available therapy options limited, especially in diseases where there may be therapeutic failure due to several factors, such as antimicrobial resistance. The union of metals such as zinc to natural derived compounds has shown potential biological activity, and this kind of strategie can be a great option to overtake some of these therapeutic problems. So, we chemically united the zinc to a vaniline compound and we found that this new drug can be a great therapeutic option presenting many biological activities, such as killing fungal and bacteria that are considered a concern for medicine, in addition to shown antioxidant effect and improving the neurological activity by blocking an important molecule involved in this process called cholinesterase. A new Schiff base derived from vanillin and Zn (II) complex has been synthesized and characterized.The Schiff base and the Zn (II) complex showed no toxicities at the concentrations tested.The Zn (II) complex showed better results in antifungal, antioxidant, and anticholinesterase activities compared to the Schiff base. A new Schiff base derived from vanillin and Zn (II) complex has been synthesized and characterized. The Schiff base and the Zn (II) complex showed no toxicities at the concentrations tested. The Zn (II) complex showed better results in antifungal, antioxidant, and anticholinesterase activities compared to the Schiff base.