cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
EXPLORATION OF MICONAZOLE AS AN ACTIVATOR OF THE 20S ISOFORM OF THE PROTEASOME
Creators: name: Salazar-Chaparro, Andres F
Publisher: name: Purdue University Graduate School
Year: 2023
Subjects: Other chemical sciences not elsewhere classified
Medicinal and biomolecular chemistry not elsewhere classified

description: The proteasome is a multi-subunit protease complex responsible for most of the non-lysosomal protein turnover in eukaryotic cells. This degradation process can be conducted dependent or independent of ubiquitination as different isoforms with different substrate preferences coexist in the cell. Proteasomal activity declines during aging due to a decreased expression of proteasome subunits, complex disassembly, and oxidative stress. This malfunction leads to protein accumulation, subsequent aggregation, and ultimately diseased states. Considering the shared feature of aggregation and accumulation of intrinsically disordered proteins (IDPs) in age-related diseases, and the substrate preference of the 20S isoform for misfolded proteins, enhancing the proteolytic activity of the 20S proteasome has arisen as an attractive strategy to minimize the burden associated with this increased protein load. Recently, we identified the FDA-approved drug miconazole (MO) as a stimulator of the 20S isoform and validated its activity profile in biochemical and cell-based assays. Given its FDA-approved drug status, we considered that to successfully repurpose it, information regarding its binding location within the 20S and network of binding partners, as well as its value in protein homeostasis in age-related diseases are necessary. Herein, we (1) conduct SAR studies to determine MO’s key features responsible for proteasomal activation and obtain molecules with enhanced ability to activate the 20S proteasome; next, using the developed SAR model, we (2) design a diazirine-based photoreactive probe that allows for the identification of MO’s binding partners and location within the 20S proteasome. Lastly, we (3) explore the use of MO to restore the activity of impaired proteasomes by Parkinson’s disease-associated toxic oligomers. This work expands upon previous research avenues by using newer approaches to study this enzymatic complex, and describes methods that can be further used to better establish the role of the 20S proteasome in age-related diseases.
LATAM
Creators: name: Manthan Janodia
name: V, Santhosh K
name: N, Aparna I
name: Radhakrishnan, Raghu
name: Magazine, Bharti Chogtu
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Architecture
subject: FOS: Civil engineering
subject: Education
subject: Arts and Humanities
subject: Engineering
subject: Social and Behavioral Sciences
subject: Physical Sciences and Mathematics

description: Bibliographic data related to LATAM countries as derived from Scopus
Additional file 1 of Evaluating preferences for colorectal cancer screening in individuals under age 50 using the Analytic Hierarchy Process
Creators: name: Hyams, Travis
name: Golden, Bruce
name: Sammarco, John
name: Sultan, Shahnaz
name: King-Marshall, Evelyn
name: Wang, Min Qi
name: Curbow, Barbara
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Neuroscience
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1.
Spin Bose-Metal and Valence Bond Solid phases in a spin-1/2 model with ring exchanges on a four-leg triangular ladder
Creators: name: Block, Matthew S.
name: Sheng, D. N.
name: Motrunich, Olexei I.
name: Fisher, Matthew P. A.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We study a spin-1/2 system with Heisenberg plus ring exchanges on a four-leg triangular ladder using the density matrix renormalization group and Gutzwiller variational wave functions. Near an isotropic lattice regime, for moderate to large ring exchanges we find a spin Bose-metal phase with a spinon Fermi sea consisting of three partially filled bands. Going away from the triangular towards the square lattice regime, we find a staggered dimer phase with dimers in the transverse direction, while for small ring exchanges the system is in a featureless rung phase. We also discuss parent states and a possible phase diagram in two dimensions.
description: 4 pages, 5 figures, v3 is the print version
Are Canadians more cosmopolitan than Americans? Evidence from study abroad programs
Creators: name: Dias, Megan
Publisher: name: University of British Columbia
Year: 2017

description: This thesis examines how cross-boarder contact affects Americans and Canadians. It argues that the specific national identity one has influences how she is affected by interactions with other cultures. It argues that key differences in the American and Canadian identities might influence how individuals from those two countries respond to cross-cultural interactions. Specifically, it argues that the different outlooks Canadians and Americans have towards multiculturalism and the different views they have about their county’s place in the world will influence how individuals from both countries respond to cross-board contact. Canadians, with their support for multiculturalism and the expectation that they should be “good global citizens,” will be more likely to see commonalities between their country and others. They feel more warmly towards, and more trusting of, individuals from other countries. At the same time, they will be less likely to see their country as superior to others. Americans, with their emphasis on assimilation and exceptionalism, will experience the opposite. To test these hypotheses, this thesis employs a natural experiment that measures how Canadian and American students were affected by studying abroad. It looks at how studying abroad changes students’ attitudes towards other countries, as well as their own, and whether these changes are different for Canadians and Americans. Ultimately, it finds little differences in the affects of studying abroad for Canadians and Americans. Studying abroad seems to cause both American and Canadian students to see greater differences between their country and others, and to feel more attached to their country.
Additional file 1 of Food environment in and around schools and colleges of Delhi and National Capital Region (NCR) in India
Creators: name: Bassi, Shalini
name: Bahl, Deepika
name: Arora, Monika
name: Tullu, Fikru Tesfaye
name: Dudeja, Sakshi
name: Gupta, Rachita
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Neuroscience
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1. Study tools.
Fluctuation-exchange approximation theory of the non-equilibrium singlet-triplet transition
Creators: name: Horváth, Bertalan
name: Lazarovits, Bence
name: Zaránd, Gergely
Publisher: name: arXiv
Year: 2010
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: As a continuation of a previous work [B. Horváth et al., Phys. Rev. B {\bf 82}, 165129 (2010)], here we extend the so-called Fluctuation Exchange Approximation (FLEX) to study the non-equilibrium singlet-triplet transition. We show that, while being relatively fast and a conserving approximation, FLEX is able to recover all important features of the transition, including the evolution of the linear conductance throughout the transition, the two-stage Kondo effect on the triplet side, and the gradual opening of the singlet-triplet gap on the triplet side of the transition. A comparison with numerical renormalization group calculations also shows that FLEX captures rather well the width of the Kondo resonance. FLEX thus offers a viable route to describe correlated multi-level systems under non-equilibrium conditions, and, in its rather general form, as formulated here, it could find a broad application in molecular electronics calculations.
description: 11 pages, 16 figures, new subsections added
BindingDB Entry 12436: TYK2 INHIBITORS
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2025
Subjects: Non-receptor tyrosine-protein kinase TYK2, Tyrosine-protein kinase JAK1, Tyrosine-protein kinase JAK2, and Tyrosine-protein kinase JAK3 [3-974], Biogen Ma, Affinity

description: Small molecule binding data for protein Non-receptor tyrosine-protein kinase TYK2, Tyrosine-protein kinase JAK1, Tyrosine-protein kinase JAK2, and Tyrosine-protein kinase JAK3 [3-974], Uniprot O60674, P23458, and P29597
Analysis of mass difference of the $π$ and $ρ$ with Bethe-Salpeter equation
Creators: name: Wang, Zhi-Gang
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: In this article, we take into account the one-pion exchange force besides the one-gluon exchange force to study the mass difference of the $π$ and $ρ$ mesons with the Bethe-Salpeter equation. After projecting the Bethe-Salpeter equation into an simple form, we can see explicitly that the bound energy $|E_π|\gg |E_ρ|$.
description: 7 pages, 1 figure, revised version
BindingDB Entry 12435: AROYL SUBSTITUTED TRICYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2025
Subjects: Tyrosine-protein kinase BTK and Tyrosine-protein kinase BTK [C481S], GENFLEET THERAPEUTICS (SHANGHAI) INC.; ZHEJIANG GENFLEET THERAPEUTICS CO., LTD., Affinity

description: Small molecule binding data for protein Tyrosine-protein kinase BTK and Tyrosine-protein kinase BTK [C481S], Uniprot Q06187
Expansion-Free Cavity Evolution: Some exact Analytical Models
Creators: name: Di Prisco, A.
name: Herrera, L.
name: Ospino, J.
name: Santos, N. O.
name: Viña-Cervantes, V. M.
Publisher: name: arXiv
Year: 2011
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We consider spherically symmetric distributions of anisotropic fluids with a central vacuum cavity, evolving under the condition of vanishing expansion scalar. Some analytical solutions are found satisfying Darmois junction conditions on both delimiting boundary surfaces, while some others require the presence of thin shells on either (or both) boundary surfaces. The solutions here obtained model the evolution of the vacuum cavity and the surrounding fluid distribution, emerging after a central explosion. This study complements a previously published work where modeling of the evolution of such kind of systems was achieved through a different kinematical condition.
description: 9 pages, Revtex. Typos corrected. Published in Int. J. Mod. Phys. D
BindingDB Entry 12434: NITRILE SUMO INHIBITORS AND USES THEREOF
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2025
Subjects: SUMO-activating enzyme subunit 1, Suvalent Therapeutics, Affinity

description: Small molecule binding data for protein SUMO-activating enzyme subunit 1, Uniprot Q9UBE0
Additional file 5 of Comparative transcriptome analysis reveals that chlorophyll metabolism contributes to leaf color changes in wucai (Brassica campestris L.) in response to cold
Creators: name: Yuan, Lingyun
name: Zhang, Liting
name: Wu, Ying
name: Zheng, Yushan
name: Nie, Libing
name: Zhang, Shengnan
name: Lan, Tian
name: Zhao, Yang
name: Zhu, Shidong
name: Hou, Jinfeng
name: Chen, Guohu
name: Tang, Xiaoyan
name: Wang, Chenggang
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Plant Biology

description: Additional file 5: Table S5. DEGs of carotenoid biosynthesis and abscisic acid biosynthesis pathways.
DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF NOVEL HIV-1 PROTEASE AND SARS- COV-2 3-CHYMOTRYPSIN LIKE PROTEASE INHIBITORS
Creators: name: Mishevich, Jennifer Lynn
Publisher: name: Purdue University Graduate School
Year: 2023
Subjects: Organic chemical synthesis

description: Over 40 years since the emergence of the AIDS epidemic and still no cure exists for AIDS or its causative HIV-1 infection. Protease inhibitors are an integral part of the most effective treatment regimen for HIV-1 infected patients known as combination antiretroviral therapy (cART), which is extremely effective at decreasing viral loads to nearly undetectable levels. One of the most alarming issues with current treatments is the emergence of multi-drug resistant strains. Even darunavir, which has shown exceptional activity against drug resistant strains, has experienced this issue. Herein we designed a novel series of heterocyclic based P2 ligand HIV-1 protease inhibitors based on kinase inhibitors such as imatinib and dasatinib. These inhibitors were designed to promote hydrogen bonding with the peptide backbone atoms of HIV-1 protease. Compounds were synthesized, biologically evaluated, and underwent X-ray structural studies. Inhibitors displayed activity as low as sub-nanomolar potency and low nanomolar antiviral activity. Important ligand-binding site interactions were determined through two X-ray crystal structures. Emergence of SARS-CoV-2 at the end of 2019 resulted in a global pandemic that has affected millions. Researchers all over the world turned their attention to developing drug therapies aimed at preventing and treating the viral infection. One such target became the main viral protease, or 3-chymotrypsin like protease (3CLpro). 3CLpro is an essential viral enzyme responsible for polypeptide cleavage during the viral replication cycle to produce 16 nonstructural proteins (nsps). Thus, it has been a highly researched area for effective SARS-CoV-2 drug therapies. Therefore, we designed, synthesized, and biologically evaluated a series of competitive reversible SARS-CoV-2 3CLpro inhibitors.
BindingDB Entry 12433: CYCLIN-DEPENDENT KINASE (CDK2) INHIBITORS
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2025
Subjects: Cyclin-dependent kinase 2/G1/S-specific cyclin-E1, Cyclin-dependent kinase 4/G1/S-specific cyclin-D1, Cyclin-dependent kinase 6/G1/S-specific cyclin-D3, and Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1, Novartis, Affinity

description: Small molecule binding data for protein Cyclin-dependent kinase 2/G1/S-specific cyclin-E1, Cyclin-dependent kinase 4/G1/S-specific cyclin-D1, Cyclin-dependent kinase 6/G1/S-specific cyclin-D3, and Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1, Uniprot P06493, P11802, P14635, P24385, P24864, P24941, P30281, and Q00534
BindingDB Entry 12432: PYRAZOLOPYRIMIDINES AND THEIR USES AS PDGFR INHIBITORS
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2025
Subjects: Platelet-derived growth factor receptor beta and Vascular endothelial growth factor receptor 2, Actelion Pharmaceuticals, Affinity

description: Small molecule binding data for protein Platelet-derived growth factor receptor beta and Vascular endothelial growth factor receptor 2, Uniprot P09619 and P35968
On Singularity formation for the L^2-critical Boson star equation
Creators: name: Lenzmann, Enno
name: Lewin, Mathieu
Publisher: name: arXiv
Year: 2011
Subjects: subject: Analysis of PDEs (math.AP)
subject: Mathematical Physics (math-ph)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: We prove a general, non-perturbative result about finite-time blowup solutions for the $L^2$-critical boson star equation $i\partial_t u = \sqrt{-Δ+m^2} \, u - (|x|^{-1} \ast |u|^2) u$ in 3 space dimensions. Under the sole assumption that the solution blows up in $H^{1/2}$ at finite time, we show that $u(t)$ has a unique weak limit in $L^2$ and that $|u(t)|^2$ has a unique weak limit in the sense of measures. Moreover, we prove that the limiting measure exhibits minimal mass concentration. A central ingredient used in the proof is a "finite speed of propagation" property, which puts a strong rigidity on the blowup behavior of $u$. As the second main result, we prove that any radial finite-time blowup solution $u$ converges strongly in $L^2$ away from the origin. For radial solutions, this result establishes a large data blowup conjecture for the $L^2$-critical boson star equation, similar to a conjecture which was originally formulated by F. Merle and P. Raphael for the $L^2$-critical nonlinear Schrödinger equation in [CMP 253 (2005), 675-704]. We also discuss some extensions of our results to other $L^2$-critical theories of gravitational collapse, in particular to critical Hartree-type equations.
description: 24 pages. Accepted in Nonlinearity
BindingDB Entry 12431: GLUN2B-SUBUNIT SELECTIVE ANTAGONISTS OF THE N-METHYL-D-ASPARTATE RECEPTORS WITH ENHANCED POTENCY AT ACIDIC PH
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2025
Subjects: Glutamate receptor ionotropic, NMDA 2B, Emory University; Neurop, Inc., Affinity

description: Small molecule binding data for protein Glutamate receptor ionotropic, NMDA 2B, Uniprot Q13224
Phase structure of finite temperature QCD in the heavy quark region
Creators: name: Saito, H.
name: Ejiri, S.
name: Aoki, S.
name: Hatsuda, T.
name: Kanaya, K.
name: Maezawa, Y.
name: Ohno, H.
name: Umeda, T.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the quark mass dependence of the finite temperature QCD phase transition in the heavy quark region using an effective potential defined through the probability distribution function of the average plaquette. Performing a simulation of SU(3) pure gauge theory, we first confirm that the distribution function has two peaks indicating that the phase transition is of first order in the heavy quark limit, while the first order transition turns into a crossover as the quark mass decreases from infinity, where the mass dependence of the distribution function is evaluated by the reweighting method combined with the hopping parameter expansion. We determine the endpoint of the first order transition region for N_f=1, 2, 3 and 2+1 cases. The quark mass dependence of the latent heat is also evaluated in the first order transition region.
description: 13 pages, 17 figures, 3 tables
Kicked-rotor quantum resonances in position space: Application to situations of experimental interest
Creators: name: Lepers, M.
name: Zehnlé, V.
name: Garreau, J. -C.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Quantum Physics (quant-ph)
subject: Quantum Gases (cond-mat.quant-gas)
subject: Atomic Physics (physics.atom-ph)
subject: FOS: Physical sciences

description: In this work we apply the formalism developed in [M. Lepers \emph{et al}., Phys. Rev. A \textbf{77}, 043628 (2008)] to different initial conditions corresponding to systems usually met in real-life experiments, and calculate the observable quantities that can be used to characterize the dynamics of the system. The position space point of view allows highly intuitive pictures of the physics at play.
description: accepted in Eur. Phys. J. D
Water-energy-carbon nexus : a system dynamics approach for assessing urban water systems
Creators: name: Chhipi Shrestha, Gyan Kumar
Publisher: name: University of British Columbia
Year: 2017

description: Water, energy, and carbon emissions of Urban Water Systems (UWSs) are intertwined and have complex interactions forming a water-energy-carbon (WEC) nexus. A comprehensive methodology to quantify dynamic WEC nexus is required. The main objective of this research is to develop a decision support system (DSS) for assessing the WEC nexus for sustainable planning and management of UWSs. This research has been accomplished in five distinct steps. In the first step, key Sustainability Performance Indicators (SPIs) of small to medium-sized UWSs have been identified. The SPIs related to water consumption, energy use, carbon emissions, and cost were used for developing the DSS. In the second step, a WEC DSS has been developed for an operational phase of an UWS using system dynamics and then applied to the City of Penticton. The highest energy consumer was found to be indoor hot water use in the city. In the third step, a framework has been developed to study the impacts of neighbourhood densification on the WEC nexus. A higher net residential density will result in lower per capita water demand, energy use, net carbon emissions, and life cycle cost of water distribution system. The proposed framework provides an optimal residential density and energy intensity of water distribution, which can be used as inputs to the WEC DSS. In the fourth step, microbial water quality guidelines for reclaimed water have been developed for various non-potable urban reuses. Moreover, the FitWater tool has been developed for evaluating fit-for-purpose wastewater treatment and reuse potentials based on cost, health risk, and the WEC nexus. The outputs of FitWater can be used as inputs to the WEC DSS. In the last step, the economics of the WEC nexus of net-zero water communities has been analyzed using the WEC model. The DSS developed based on this research is capable of quantifying dynamic water consumption, energy use, carbon emissions, and the cost of UWSs. The DSS can analyze different WEC-based interventions. The DSS can be used by utilities, urban developers, and policy makers for long-term planning of urban water in communities.
BindingDB Entry 12430: COMPOUNDS FOR NEUTROPHIL ROS INHIBITION
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2025
Subjects: Proto-oncogene tyrosine-protein kinase ROS, IMMUNYX PHARMA LTD.; YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.; Hadasit Medical Research Services and Development Ltd., Affinity

description: Small molecule binding data for protein Proto-oncogene tyrosine-protein kinase ROS, Uniprot P08922 and Q78DX7
Service system innovation: an ambidexterity perspective
Creators: name: Wolf, Verena
Publisher: name: Universität Paderborn
Year: 2020

description: Die digitale Transformation prägt die Entwicklung von innovativen Dienstleistungssystemen und deren Management. Einerseits entstehen Potentiale durch die Verfügbarkeit von neuen Ressourcen, wie z.B. Daten und digitalen Technologien, sodass neue Wertversprechen ermöglicht werden. Andererseits entstehen durch die hohe Dynamik am Markt auch Herausforderungen, da Innovationszyklen verkürzt werden müssen. Auf der Unternehmensseite besteht dadurch der Bedarf, dass Entwicklung und Anwendung von Dienstleistungsinnovationen verschmelzen. Mithilfe der Theorie der Ambidextrie werden in der Dissertation neue erkenntnistheoretische und gestaltungsorientierte Forschungsbeiträge geschaffen, welche eine integrierte Sichtweise auf Innovation ermöglichen. Dabei wird Innovation in Dienstleistungssystemen als sich gegenseitig konstituierende Mechanismen von Exploration und Exploitation konzeptualisiert. Exploration kann durch agile und flexible Vorgehensmodelle und Methoden des Service System Engineering erfolgen. Eine wichtige Aktivität stellt dabei die Transformation von bestehenden Strukturen, Geschäftsprozessen und Organisationsroutinen dar. Die eigenständige Abweichung von Mitarbeitern in Organisationsroutinen stellt eine Form von Exploitation dar. Insbesondere Workarounds bilden eine wichtige Quelle für Innovation, welche das Potential haben eine Organisation bottom-up zu transformieren.
description: Digital transformation affects the development and management of innovative service systems. On the one hand, potentials are created through the availability of new types of resources, e.g., data and digital technologies, enabling new value propositions. On the other hand, challenges arise through highly dynamic markets, requiring faster innovation cycles. Therefore, organizations need to span the boundaries between the development and management of service system innovation.By taking ambidexterity as a theoretical lens, the dissertation provides descriptive and prescriptive knowledge to achieve an integrated view on service system innovation. In this regard, innovation can be conceptualized as mutual constitutive mechanisms of exploration and exploitation. Exploration can be achieved through agile and flexible methods of service system engineering. Essential activities of exploration are the transformation of existing structures, business processes, and organizational routines. The unacknowledged deviation of employees in organizational routines constitutes a type of exploitation. Especially workarounds can be an important source of innovation, having the potential to transform an organization bottom-up.
Enhancing Creative, Learning and Collaborative Experiences through Augmented Reality-compatible Internet-of-Things Devices
Creators: name: Raja, Pashin Farsak
Publisher: name: Purdue University Graduate School
Year: 2023
Subjects: Mechanical engineering not elsewhere classified
Mechatronics hardware design and architecture
Human-computer interaction
Cyberphysical systems and internet of things
Electronic device and system performance evaluation, testing and simulation
Simulation, modelling, and programming of mechatronics systems
Graphics, augmented reality and games not elsewhere classified
Analog electronics and interfaces

description: The "Maker Movement" is a cultural phenomena rooted in DIY culture, which stresses making devices and creations on your own rather than purchasing it ready-made. At the core of the Maker Movement, is the "Maker Mindset"; a collection of attitudes, beliefs and behaviors that emphasize the importance of creativity, experimentation and innovation in the learning process. Since the Maker Mindset embodies constructionist principles at its core that push makers to experiment and problem-solve by collaborating with fellow makers through hands-on activities, it can be said that these activities comprise of Creative, Learning and Collaborative experiences. While Internet-of-Things devices have long been used to enhance these activities, research pertaining to using Augmented Reality in tandem with IoT for the purpose of enhancing experiences core to the Maker Mindset is relatively unexplored. Three different systems were developed with the goal of addressing this -- MicrokARts, ShARed IoT and MechARspace. Each system focuses on enhancing one of the three core experiences through AR-compatible IoT devices, whilst ensuring that they do not require prerequisite knowledge in order to author AR experiences. These systems were evaluated through user studies and testing over a variety of age-groups, with each system successfully enhancing one core experience each through the use of AR-IoT interactions.
Additional file 1 of Frequency of basic public health services utilization by married female migrants in China: associations of social support, discrimination and sociodemographic factors
Creators: name: Hu, Xin
name: Sun, Mei
name: Tang, Siyuan
name: Lommel, Lisa L.
Publisher: name: figshare
Year: 2021
Subjects: subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy

description: Additional file 1. The questionnaire of women’s demographic and social structure information.
Additional file 1 of Satellite-based modelling of potential tsetse (Glossina pallidipes) breeding and foraging sites using teneral and non-teneral fly occurrence data
Creators: name: Gachoki, Stella
name: Groen, Thomas
name: Vrieling, Anton
name: Okal, Michael
name: Skidmore, Andrew
name: Masiga, Daniel
Publisher: name: figshare
Year: 2021
Subjects: subject: Biochemistry
subject: Neuroscience
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Hematology

description: Additional file 1: Figure S1. Boxplots showing the seasonal 16-day MODIS NDVI within the study area (Shimba Hills National Reserve and its surrounding). Figure S2 and Figure S3. Histograms showing the distribution of traps based on the relative land cover classes abundance generated using the 1010 × 1010 m moving window during the dry and wet season, respectively.
Class A Spacetimes
Creators: name: Suhr, Stefan
Publisher: name: arXiv
Year: 2010
Subjects: subject: Differential Geometry (math.DG)
subject: FOS: Mathematics
subject: 53C50

description: We introduce class A spacetimes, i.e. compact vicious spacetimes $(M,g)$ such that the Abelian cover $(\bar{M},\bar{g})$ is globally hyperbolic. We study the main properties of class A spacetimes using methods similar to the one introduced in D. Sullivan "Cycles for the dynamical study of foliated manifolds and complex manifolds" (Invent. Math.,36, 225-255 (1976)) and D. Yu. Burago "Periodic metrics" (Representation theory and dynamical systems (Adv. Soviet Math.), 9, 205-210 (1992)). As a consequence we are able to characterize manifolds admitting class A metrics completely as mapping tori. Further we show that the notion of class A spacetime is equivalent to that of SCTP (spacially compact time-periodic) spacetimes as introduced in Galloway "Splitting theorems for spatially closed spacetimes" (Comm Math Phys 96:423-429, 1984). The set of class A spacetimes is shown to be open in the $C^0$-topology on the set of Lorentzian metrics. As an application we prove a coarse Lipschitz property for the time separation of the Abelian cover. This coarse Lipschitz property is an essential part in the study of Aubry-Mather theory in Lorentzian geometry.
description: 26 pages, comments welcome; Geometriae Dedicata 2011
A new three-parameter correlation for gamma-ray bursts with a plateau phase in the afterglow
Creators: name: Xu, M.
name: Huang, Y. F.
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Gamma ray bursts (GRBs) have great advantages for their huge burst energies, luminosities and high redshifts in probing the Universe. A few interesting luminosity correlations of GRBs have been used to test cosmology models. Especially, for a subsample of long GRBs with known redshifts and a plateau phase in the afterglow, a correlation between the end time of the plateau phase (in the GRB rest frame) and the corresponding X-ray luminosity has been found. In this paper, we re-analyze the subsample and found that a significantly tighter correlation exists when we add a third parameter, i.e. the isotropic $γ$-ray energy release, into the consideration. Additionally, both long and intermediate duration GRBs are consistent with the same three-parameter correlation equation. It is argued that the new three-parameter correlation is consistent with the hypothesis that the subsample of GRBs with a plateau phase in the afterglow be associated with the birth of rapidly rotating magnetars, and that the plateau be due to the continuous energy-injection from the magnetar. It is suggested that the newly born millisecond magnetars associated with GRBs might provide a good standard candle in the Universe.
description: 11 pages, 3 figures, 1 table; A&A, in press
BindingDB Entry 12428: PHARMACEUTICAL AND FOOD COMPOSITIONS FOR THE PREVENTION, ALLEVIATION, OR TREATMENT OF INFLAMMATORY DISEASES COMPRISING 1-ALKYL-5-ARYLIDENE-2-SELENOXOIMIDAZOLIDIN-4-ONE AND ITS DERIVATIVES
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2025
Subjects: NADPH oxidase 1, DUKSUNG WOMEN''S UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION; INDUSTRY ACADEMIC COOPERATION FOUNDATION OF YEUNGNAM UNIVERSITY, Affinity

description: Small molecule binding data for protein NADPH oxidase 1, Uniprot Q9Y5S8
BindingDB Entry 12427: Substituted pyrazolo[1,5-a]pyridine compound, composition containing the same and use thereof
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2025
Subjects: Proto-oncogene tyrosine-protein kinase receptor Ret and Proto-oncogene tyrosine-protein kinase receptor Ret [V804M], Shenzhen Targetrx, Affinity

description: Small molecule binding data for protein Proto-oncogene tyrosine-protein kinase receptor Ret and Proto-oncogene tyrosine-protein kinase receptor Ret [V804M], Uniprot P07949
SPATIOTEMPORAL MAPPING OF CARBON DIOXIDE CONCENTRATIONS AND FLUXES IN A MECHANICAL VENTILATION SYSTEM OF A LIVING LABORATORY OFFICE
Creators: name: Huang, Junkai
Publisher: name: Purdue University Graduate School
Year: 2023
Subjects: Architectural engineering
Air pollution modelling and control

description: Indoor air quality in office buildings can impact the health, well-being, and productivity of occupants. In most buildings, occupants exhaled breath is the primary source of carbon dioxide (CO2). Concentrations of indoor CO2 are also strongly associated with the operational mode of the mechanical ventilation system. While CO2 is routinely monitored in indoor environments, there are few spatially-resolved real-time measurements of CO2 throughout mechanical ventilation systems. Such measurements can provide insight into indoor- and outdoor-generated CO2 dispersion throughout a building and between the building and the outdoor atmosphere. This thesis aims to investigate spatiotemporal variations in CO2 concentrations and mass fluxes throughout a mechanical ventilation system of a living laboratory office in a LEED-certified building. The impact of human occupancy patterns and ventilation conditions of CO2 concentrations and fluxes was evaluated. A four-month measurement campaign was conducted in one of the four living laboratory offices at the Ray W. Herrick Laboratories. The living laboratory offices feature precise control and monitoring of the mechanical ventilation system via an advanced building automation system. Various mechanical ventilation modes were implemented, such as variable outdoor air exchange rates (AERs) and recirculation ratios. A novel multi-location sampling manifold was used to measure CO2 at eight locations throughout the ventilation system, such as across the outdoor, supply, and return air ducts. Office occupancy was measured via a chair-based temperature sensor array. Volumetric airflow rate data and CO2 concentration data were used to estimate CO2 mass fluxes through the ventilation system. The CO2 mass flux for the outdoor and exhaust air was used to evaluate the net CO2 transport from the office to the outdoor atmosphere. The measurements demonstrate that there exist significant spatiotemporal variations in CO2 concentrations across the outdoor, supply, and return air ducts. CO2 concentrations varied with human occupancy in the office and the outdoor AER of the mechanical ventilation system. Due to human-associated CO2 emissions, the net CO2 mass flux from the office to the outdoor environment was approximately 700 kg of CO2 per year. Thus, occupied offices may represent an important, yet unrecognized, source of CO2 to the urban atmosphere.
Updated Results from the RICE Experiment and Future Prospects for Ultra-High Energy Neutrino Detection at the South Pole
Creators: name: Kravchenko, Ilya
name: Seckel, Dave
name: Besson, Dave
name: Ralston, John
name: Taylor, John
name: Ratzlaff, Ken
name: Young, Rob
Publisher: name: arXiv
Year: 2011
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The RICE experiment seeks observation of ultra-high energy (UHE; >100 PeV) neutrinos interacting in Antarctic ice, by measurement of the radiowavelength Cherenkov radiation resulting from the collision of a neutrino with an ice molecule. RICE was initiated in 1999 as a first-generation prototype for an eventual, large-scale in-ice UHE neutrino detector. Herein, we present updated limits on the diffuse UHE neutrino flux, based on twelve years of data taken between 1999 and 2010. We find no convincing neutrino candidates, resulting in 95% confidence-level model-dependent limits on the flux which improve on our previous (2006) results by a factor of two. We also report on ice properties' studies, including observation of radiowave reflections from layers internal to the ice sheet. We observe correlations of these reflections with the local ice flow direction, and also qualitatively verify the expected reduction in radio frequency ice transparency with increasing depth/temperature. A new experimental initiative (the Askaryan Radio Array, ARA) commenced at South Pole in 2010-11 will improve the RICE sensitivity (per unit time) by approximately two orders of magnitude.
description: version accepted for publication in Phys. Rev. D
BindingDB Entry 12426: Diaryl macrocyclic compound and pharmaceutical composition, and use thereof
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2025
Subjects: ALK tyrosine kinase receptor [L1196M], BDNF/NT-3 growth factors receptor, High affinity nerve growth factor receptor, NT-3 growth factor receptor, Proto-oncogene tyrosine-protein kinase ROS, and Proto-oncogene tyrosine-protein kinase ROS [G2032R], Primegene (Beijing) Co., Affinity

description: Small molecule binding data for protein ALK tyrosine kinase receptor [L1196M], BDNF/NT-3 growth factors receptor, High affinity nerve growth factor receptor, NT-3 growth factor receptor, Proto-oncogene tyrosine-protein kinase ROS, and Proto-oncogene tyrosine-protein kinase ROS [G2032R], Uniprot P04629, P08922, Q16288, Q16620, and Q9UM73
Additional file 2 of Same, same, but different? A longitudinal, mixed-methods study of stability in values and preferences for future end-of-life care among community-dwelling, older adults
Creators: name: Eneslätt, Malin
name: Helgesson, Gert
name: Tishelman, Carol
Publisher: name: figshare
Year: 2021
Subjects: subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Cancer
subject: Science Policy
subject: Computational Biology

description: Additional file 2. Supplemental demographic information.
An isoperimetric inequality for a nonlinear eigenvalue problem
Creators: name: Croce, Gisella
name: Henrot, Antoine
name: Pisante, Giovanni
Publisher: name: arXiv
Year: 2011
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: We prove an isoperimetric inequality of the Rayleigh-Faber-Krahn type for a nonlinear generalization of the first twisted Dirichlet eigenvalue. More precisely, we show that the minimizer among sets of given volume is the union of two equal balls.
description: Annales de l'Institut Henri Poincar\'e Analyse non lin\'eaire (2012) 15 pages; Equipe Equations aux d\'eriv\'ees partielles et applications
Additional file 1 of Posttraumatic stress disorder and the risk of erectile dysfunction: a nationwide cohort study in Taiwan
Creators: name: Wang, Sheng-Chiang
name: Chien, Wu-Chien
name: Chung, Chi-Hsiang
name: Tzeng, Nian-Sheng
name: Liu, Yia-Ping
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Additional file 1: Table S1. ICD-9-CM codes of comorbidities and major outcomes.
Latest Cosmological Constraints on Cardassian expansion models including the updated Gamma-ray bursts
Creators: name: Liang, Nan
name: Wu, Puxun
name: Zhu, Zong-Hong
Publisher: name: arXiv
Year: 2010
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: In this paper, we constrain the Cardassian expansion models from the latest observations including the updated Gamma-ray bursts (GRBs), which calibrated cosmology-independently from the Union2 compilation of type Ia supernovae (SNe Ia). By combining the GRB data to the joint observations with the Union2 SNe Ia set, along with the Cosmic Microwave Background radiation observation from the seven-year Wilkinson Microwave Anisotropy Probe result, the baryonic acoustic oscillation observation from the spectroscopic Sloan Digital Sky Survey Data Release galaxy sample, we find significant constraints on model parameters of the original Cardassian model $Ω_{\rm M0}=0.282_{-0.014}^{+0.015}$, $n= 0.03_{-0.05}^{+0.05}$; and $n= -0.16_{-3.26}^{+0.25}$, $β=0.76_{-0.58}^{+0.34}$ of the modified polytropic Cardassian model, which are consistent with the $Λ$CDM model in 1-$σ$ confidence region. From the reconstruction of the deceleration parameter $q(z)$ in Cardassian models, we obtain the transition redshift $z_{\rm T}=0.73\pm{0.04}$ for the original Cardassian model, and $z_{\rm\rm T}=0.68\pm{0.04}$ for the modified polytropic Cardassian model.
description: 11 pages, 5 figures, 1 table; accepted for publication in Res. Astron. Astrophys
The use of 185 nm radiation for drinking water treatment
Creators: name: Furatian, Laith
Publisher: name: University of British Columbia
Year: 2017

description: The treatment of water via 185 nm radiation allows for the oxidative degradation of trace organic contaminants without the need for chemical addition. Critical information required for the practical application of such a process has been lacking. Carbamazepine was determined to be an ideal probe compound for study of the 185 nm regime due to negligible direct photolysis at 254 nm. An increase in probe degradation rate due to 185 nm is observed with increasing temperature when water is the only significant absorber of photons. A comparison with the temperature dependence of the 254 nm - H₂O₂ process is made and a fundamental explanation proposed. Experimental evidence reveals that probe degradation rate is strongly influenced by anionic composition at environmentally relevant concentrations, particularly chloride. Evidence for the role of the chlorine radical is obtained by kinetic studies involving select probes, radical scavengers, and ionic strength. Interactions between the major organic and inorganic solutes indicate that resulting degradation kinetics are highly sensitive to the composition of the water matrix, a fact that has been neglected from the literature. A method to quantify molar absorption coefficients is developed that is not prone to errors due to stray radiant energy or wavelength inaccuracies. A method to quantify the 185:254 nm output of a low pressure mercury lamp is presented with results in agreement with values reported in the literature. In addition to the hydroxyl radical (*OH), other radical species such as chlorine (C1*) and sulphate (SO₄*¯) are proposed to be involved in oxidative degradation of trace organics in the 185 nm regime. This suggests that the degradation rate of a given target contaminant depends on the composition of the water matrix, the second-order rate constants with the relevant radicals, and the relative reaction rate constants of the target and the matrix.
การพัฒนาศิลปะการแสดงจากพิธีกรรมมม็อดของกลุ่มชาติพันธุ์ไทยเขมร
Creators: name: ณัชชา อ่อนหวาน
Publisher: name: The Office of Arts and Culture, Surindra Rajabhat University
Year: 2015
Subjects: ศิลปะการแสดง
พิธีกรรมมม๊อด
กลุ่มชาติพันธุ์ไทยเขมร

description: วารสารศิลปะและวัฒนธรรมลุ่มแม่น้ำมูล, 10, 1, 7-21
การประเมินสื่อการสอนรายวิชาสังคมกับสิ่งแวดล้อม
Creators: name: กุลปวีณ์ สมานทอง
Publisher: name: The Office of Arts and Culture, Surindra Rajabhat University
Year: 2015
Subjects: สื่อการเรียนการสอน
สื่อพี.ที.ที
บริบทของวัฒนธรรมเชิงพื้นที่
สังคมเศรษฐกิจ
ความพึงพอใจ

description: วารสารศิลปะและวัฒนธรรมลุ่มแม่น้ำมูล, 10, 1, 22-30
BindingDB Entry 12425: Chromobox protein inhibitors and uses thereof
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2025
Subjects: Chromobox protein homolog 2 and Chromobox protein homolog 7, Dana-Farber Cancer Institute, Affinity

description: Small molecule binding data for protein Chromobox protein homolog 2 and Chromobox protein homolog 7, Uniprot O95931 and Q14781
Natural selection of inflationary vacuum required by infra-red regularity and gauge-invariance
Creators: name: Urakawa, Yuko
name: Tanaka, Takahiro
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: It has been an issue of debate whether the inflationary infrared(IR) divergences are physical or not. Our claim is that, at least, in single-field models, the answer is "No," and that the spurious IR divergence is originating from the careless treatment of the gauge modes. In our previous work we have explicitly shown that the IR divergence is absent in the genuine gauge-invariant quantity at the leading order in the slow-roll approximation. We extend our argument to include higher-order slow-roll corrections and the contributions from the gravitational waves. The key issue is to assure the gauge invariance in the choice of the initial vacuum, which is a new concept that has not been considered in conventional calculations.
description: 12 pages; v3: several descriptions are added; v4: accepted version in PTP
แนวทางการส่งเสริมธุรกิจครอบครัวบริเวณตลาดการค้าชายแดนอีสานใต้
Creators: name: ธราธร ภูพันเชือก
Publisher: name: The Office of Arts and Culture, Surindra Rajabhat University
Year: 2015
Subjects: ธุรกิจครอบครัว
แนวทางการส่งเสริมธุรกิจครอบครัว
ตลาดการค้าชายแดนอีสานใต้

description: วารสารศิลปะและวัฒนธรรมลุ่มแม่น้ำมูล, 10, 1, 31-39
BindingDB Entry 12424: Difluoro phenyl amide RIP1 inhibitor
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2025
Subjects: Receptor-interacting serine/threonine-protein kinase 1, Sironax, Affinity

description: Small molecule binding data for protein Receptor-interacting serine/threonine-protein kinase 1, Uniprot Q13546
Additional file 3 of Optimal dose of perineural dexmedetomidine to prolong analgesia after brachial plexus blockade: a systematic review and Meta-analysis of 57 randomized clinical trials
Creators: name: Cai, Hai
name: Fan, Xing
name: Feng, Pengjiu
name: Wang, Xiaogang
name: Xie, Yubo
Publisher: name: figshare
Year: 2021
Subjects: subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy
subject: Hematology

description: Additional file 3. Regression analysis of perineural DEX dose and mean increase in DOA when combined with long-acting LAs (pink line: mean line; green line: fitting line). Abbreviations: DEX, dexmedetomidine; DOA, duration of analgesia; LA, local anesthetic.
BindingDB Entry 12423: Heterocyclic sulfonamide derivatives and pharmaceutical uses thereof
Creators: name: BindingDB
Publisher: name: BindingDB
Year: 2025
Subjects: Potassium voltage-gated channel subfamily A member 3, Metrion Biosciences, Affinity

description: Small molecule binding data for protein Potassium voltage-gated channel subfamily A member 3, Uniprot P22001
กระบวนการถ่ายทอดภูมิปัญญาสู่การพัฒนาท้องถิ่นสร้างสรรค์ จังหวัดสุรินทร์
Creators: name: ศุภางค์ นันตา
Publisher: name: The Office of Arts and Culture, Surindra Rajabhat University
Year: 2015
Subjects: ภูมิปัญญา
การพัฒนาท้องถิ่น

description: วารสารศิลปะและวัฒนธรรมลุ่มแม่น้ำมูล, 10, 1, 40-48