Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
Creators: name: Vogelezang, Suzanne
name: Bradfield, Jonathan P.
name: Ahluwalia, Tarunveer S.
name: Curtin, John A.
name: Lakka, Timo A.
name: Grarup, Niels
name: Scholz, Markus
name: Van Der Most, Peter J.
name: Monnereau, Claire
name: Stergiakouli, Evie
name: Heiskala, Anni
name: Horikoshi, Momoko
name: Fedko, Iryna O.
name: Vilor-Tejedor, Natalia
name: Cousminer, Diana L.
name: Standl, Marie
name: Wang, Carol A.
name: Viikari, Jorma
name: Geller, Frank
name: Íñiguez, Carmen
name: Pitkänen, Niina
name: Chesi, Alessandra
name: Bacelis, Jonas
name: Yengo, Loic
name: Torrent, Maties
name: Ntalla, Ioanna
name: Helgeland, Øyvind
name: Selzam, Saskia
name: Vonk, Judith M.
name: Zafarmand, Mohammed H.
name: Heude, Barbara
name: Farooqi, Ismaa Sadaf
name: Alyass, Akram
name: Beaumont, Robin N.
name: Have, Christian T.
name: Rzehak, Peter
name: Bilbao, Jose Ramon
name: Schnurr, Theresia M.
name: Barroso, Inês
name: Bønnelykke, Klaus
name: Beilin, Lawrence J.
name: Carstensen, Lisbeth
name: Charles, Marie-Aline
name: Chawes, Bo
name: Clément, Karine
name: Closa-Monasterolo, Ricardo
name: Custovic, Adnan
name: Eriksson, Johan G.
name: Escribano, Joaquin
name: Groen-Blokhuis, Maria
name: Grote, Veit
name: Gruszfeld, Dariusz
name: Hakonarson, Hakon
name: Hansen, Torben
name: Hattersley, Andrew T.
name: Hollensted, Mette
name: Hottenga, Jouke-Jan
name: Hyppönen, Elina
name: Johansson, Stefan
name: Joro, Raimo
name: Kähönen, Mika
name: Karhunen, Ville
name: Kiess, Wieland
name: Knight, Bridget A.
name: Koletzko, Berthold
name: Kühnapfel, Andreas
name: Landgraf, Kathrin
name: Langhendries, Jean-Paul
name: Lehtimäki, Terho
name: Leinonen, Jaakko T.
name: Li, Aihuali
name: Lindi, Virpi
name: Lowry, Estelle
name: Bustamante, Mariona
name: Medina-Gomez, Carolina
name: Melbye, Mads
name: Michaelsen, Kim F.
name: Morgen, Camilla S.
name: Mori, Trevor A.
name: Nielsen, Tenna R. H.
name: Niinikoski, Harri
name: Oldehinkel, Albertine J.
name: Pahkala, Katja
name: Panoutsopoulou, Kalliope
name: Pedersen, Oluf
name: Pennell, Craig E.
name: Power, Christine
name: Reijneveld, Sijmen A.
name: Rivadeneira, Fernando
name: Simpson, Angela
name: Sly, Peter D.
name: Stokholm, Jakob
name: Teo, Kook K.
name: Thiering, Elisabeth
name: Timpson, Nicholas J.
name: Uitterlinden, André G.
name: Van Beijsterveldt, Catharina E. M.
name: Van Schaik, Barbera D. C.
name: Vaudel, Marc
name: Verduci, Elvira
name: Vinding, Rebecca K.
name: Vogel, Mandy
name: Zeggini, Eleftheria
name: Sebert, Sylvain
name: Lind, Mads V.
name: Brown, Christopher D.
name: Santa-Marina, Loreto
name: Reischl, Eva
name: Frithioff-Bøjsøe, Christine
name: Meyre, David
name: Wheeler, Eleanor
name: Ong, Ken
name: Nohr, Ellen A.
name: Vrijkotte, Tanja G. M.
name: Koppelman, Gerard H.
name: Plomin, Robert
name: Njølstad, Pål R.
name: Dedoussis, George D.
name: Froguel, Philippe
name: Sørensen, Thorkild I. A.
name: Jacobsson, Bo
name: Freathy, Rachel M.
name: Zemel, Babette S.
name: Raitakari, Olli
name: Vrijheid, Martine
name: Feenstra, Bjarke
name: Lyytikäinen, Leo-Pekka
name: Snieder, Harold
name: Kirsten, Holger
name: Holt, Patrick G.
name: Heinrich, Joachim
name: Widén, Elisabeth
name: Sunyer, Jordi
name: Boomsma, Dorret I.
name: Järvelin, Marjo-Riitta
name: Körner, Antje
name: Davey Smith, George
name: Holm, Jens-Christian
name: Atalay, Mustafa
name: Murray, Clare
name: Bisgaard, Hans
name: McCarthy, Mark I.
name: Early Growth Genetics Consortium
name: Jaddoe, Vincent W. V.
name: Grant, Struan F. A.
name: Felix, Janine F.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: subject: Research Article
subject: Biology and life sciences
subject: Research and analysis methods
subject: Physical sciences
subject: FOS: Physical sciences
subject: FOS: Physical sciences
subject: Medicine and health sciences

description: The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values &lt;0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.