cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Overdensity of submillimeter galaxies around the $z\simeq 2.3$ MAMMOTH-1 nebula
Creators: name: Battaia, F. Arrigoni
name: Chen, Chian-Chou
name: Fumagalli, M.
name: Cai, Zheng
name: Rivera, G. Calistro
name: Xu, Joachuan
name: Smail, I.
name: Prochaska, J. X.
name: Yang, Yujin
name: De Breuck, C.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: In the hierarchical model of structure formation, giant elliptical galaxies form through merging processes within the highest density peaks known as protoclusters. While high-redshift radio galaxies usually pinpoint the location of these environments, we have recently discovered at z~2-3 three Enormous (>200 kpc) Lyman-Alpha Nebulae (ELANe) that host multiple AGN and that are surrounded by overdensities of Lyman-alpha Emitters (LAE). These regions are prime candidates of massive protoclusters in the early stages of assembly. To characterize the star-forming activity within these rare structures - both on ELAN and protocluster scales - we have initiated an observational campaign with the JCMT and the APEX telescopes. In this paper we report on sensitive SCUBA-2/JCMT 850 and 450 $μ$m observations of a 128 arcmin$^2$ field comprising the ELAN MAMMOTH-1, together with the peak of the hosting BOSS1441 LAE overdensity at z=2.32. These observations unveil $4.0\pm1.3$ times higher source counts at 850 $μ$m with respect to blank fields, likely confirming the presence of an overdensity also in obscured tracers. We find a strong detection at 850 $μ$m associated with the continuum source embedded within the ELAN MAMMOTH-1, which - together with the available data from the literature - allow us to constrain the spectral energy distribution of this source to be of an ULIRG with a far-infrared luminosity of $L_{\rm FIR}^{\rm SF}=2.4^{+7.4}_{-2.1}\times10^{12}$ L$_{\odot}$, and hosting an obscured AGN. Such a source is thus able to power the hard photoionization plus outflow scenario depicted in Cai et al. (2017b) to explain the extended Lyman-alpha, HeII$\lambda1640$ and CIV$\lambda1549$ emission, and their kinematics. In addition, the two brightest detections at 850 $μ$m ($f_{850}>18$ mJy) sit at the density peak of the LAEs overdensity, likely pinpointing the core of the protocluster.
description: 17 pages, 12 figures, 8 tables; Accepted for publication in A&A
Additional file 2: of Effects of unaltered and bioconverted mulberry leaf extracts on cellular glucose uptake and antidiabetic action in animals
Creators: name: Jung, Sang-Hyuk
name: Joo-Hui Han
name: Park, Hyun-Soo
name: Lee, Do-Hyung
name: Kim, Seok
name: Cho, Hyun
name: Kang, Jong
name: Chang-Seon Myung
Publisher: name: figshare
Year: 2019
Subjects: subject: Biochemistry
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Plant Biology

description: The following information is available online: In vitro test of the cytotoxicity of the bioconverted and unaltered mulberry lead extracts (BMLE and MLE, respectively) used in this study. (PDF 1633 kb)
Experimental quantum teleportation
Creators: name: Bouwmeester, Dik
name: Pan, Jian-Wei
name: Mattle, Klaus
name: Eibl, Manfred
name: Weinfurter, Harald
name: Zeilinger, Anton
Publisher: name: arXiv
Year: 2019
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Quantum teleportation -- the transmission and reconstruction over arbitrary distances of the state of a quantum system -- is demonstrated experimentally. During teleportation, an initial photon which carries the polarization that is to be transferred and one of a pair of entangled photons are subjected to a measurement such that the second photon of the entangled pair acquires the polarization of the initial photon. This latter photon can be arbitrarily far away from the initial one. Quantum teleportation will be a critical ingredient for quantum computation networks.
description: 7 pages, 5 figures
OpenSafeDrive-PrivacyProtect
Creators: name: École Centrale d'Électronique
Publisher: name: PFE Gérer et Protéger l'alcoolémie
Year: 2025
Subjects: Alcoolemie
protection des données
recherche

description: Ce projet est un projet de recherche qui cherche des solutions quant à la possibilité de protéger nos données personnelles en cas d'alcoolémie, et aide à déterminer notre aptitude à prendre le volant pour garantir la sécurité des usagers de la route
title: Abbildung der Inanspruchnahme palliativer Versorgung anhand bundesweit und regional verfügbarer Verordnungsziffern und Leistungsabrechnungen
Creators: name: Ditscheid, Bianka
name: Krause, Markus
name: Lehmann, Thomas
name: L’hoest, Helmut
name: Marschall, Ursula
name: Meißner, Winfried
name: Freytag, Antje
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Die Verfügbarkeit palliativer Versorgung (PV) hat in Deutschland in den letzten Jahren stark zugenommen. Die Versorgungsformen umfassen u.a. die (allgemeine) ambulante Palliativversorgung (AAPV) durch Hausärzte und niedergelassene Spezialisten, die spezialisierte ambulante Palliativversorgung[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 18. Deutscher Kongress für Versorgungsforschung (DKVF)
Plasmons in coupled bilayer structures
Creators: name: Sarma, S. Das
name: Hwang, E. H.
Publisher: name: arXiv
Year: 1998
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We calculate the collective charge density excitation dispersion and spectral weight in bilayer semiconductor structures {\it including effects of interlayer tunneling}. The out-of-phase plasmon mode (the ``acoustic'' plasmon) develops a long wavelength gap in the presence of tunneling with the gap being proportional to the square root (linear power) of the tunneling amplitude in the weak (strong) tunneling limit. The in-phase plasmon mode is qualitatively unaffected by tunneling. The predicted plasmon gap should be a useful tool for studying many-body effects.
description: 10 pages, 6 figures. to appear in Phys. Rev. Lett
Thermal conductivity of Mg-doped CuGeO_3 at very low temperatures: Heat conduction by antiferromagnetic magnons
Creators: name: Takeya, J.
name: Tsukada, I.
name: Ando, Yoichi
name: Masuda, T.
name: Uchinokura, K.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Thermal conductivity κis measured at very low temperatures down to 0.28 K for pure and Mg-doped CuGeO_3 single crystals. The doped samples carry larger amount of heat than the pure sample at the lowest temperature. This is because antiferromagnetic magnons appear in the doped samples and are responsible for the additional heat conductivity, while κof the pure sample represents phonon conductivity at such low temperatures. The maximum energy of the magnon is estimated to be much lower than the spin-Peierls-gap energy. The result presents the first example that κat very low temperatures probes the magnon transport in disorder-induced antiferromagnetic phase of spin-gap systems.
OpenSafeDrive-PrivacyProtect
Creators: name: École Centrale d'Électronique
Publisher: name: Zenodo
Year: 2025
Subjects: Alcoolemie
protection des données
recherche

description: Ce projet est un projet de recherche qui cherche des solutions quant à la possibilité de protéger nos données personnelles en cas d'alcoolémie, et aide à déterminer notre aptitude à prendre le volant pour garantir la sécurité des usagers de la route
title: Abgrenzung von Bedarfen und Einordnung in palliative Versorgungsformen aus Sicht von Hausärzten
Creators: name: Volkert, Anna
name: Peter, Sophie
name: Pfaff, Holger
name: Scholten, Nadine
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Neben der palliativen hausärztlichen Regelversorgung und der allgemeinen ambulanten Palliativversorgung (AAPV), die durch Hausärzte mit entsprechender Fortbildung geleistet wird, ist die spezialisierte ambulante Palliativversorgung (SAPV) eine weitere ambulante Versorgungsform,[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 18. Deutscher Kongress für Versorgungsforschung (DKVF)
Evolution of Fixed-End Strings and the Off-Shell Disk Amplitude
Creators: name: Orland, Peter
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: An exact integral expression is found for the amplitude of a Bosonic string with ends separated by a fixed distance $R$ evolving over a time $T$ between arbitrary initial and final configurations. It is impossible to make a covariant subtraction of a covariant quantity which would render the amplitude non-zero. It is suggested that this fact (and not the tachyon) is responsible for the lack of a continuum limit of regularized random-surface models with target-space dimension greater than one. It appears consistent, however, to remove this quantity by hand. The static potential of Alvarez and Arvis $V(R)$ is recovered from the resulting finite amplitude for $R>R_{c}$. For $R
description: Latex file, 19 pages, no figures
Multiple topic identification in telephone conversations
Creators: name: Bost, Xavier
name: Bèze, Marc El
name: De Mori, Renato
Publisher: name: arXiv
Year: 2018
Subjects: subject: Computation and Language (cs.CL)
subject: FOS: Computer and information sciences

description: This paper deals with the automatic analysis of conversations between a customer and an agent in a call centre of a customer care service. The purpose of the analysis is to hypothesize themes about problems and complaints discussed in the conversation. Themes are defined by the application documentation topics. A conversation may contain mentions that are irrelevant for the application purpose and multiple themes whose mentions may be interleaved portions of a conversation that cannot be well defined. Two methods are proposed for multiple theme hypothesization. One of them is based on a cosine similarity measure using a bag of features extracted from the entire conversation. The other method introduces the concept of thematic density distributed around specific word positions in a conversation. In addition to automatically selected words, word bi-grams with possible gaps between successive words are also considered and selected. Experimental results show that the results obtained with the proposed methods outperform the results obtained with support vector machines on the same data. Furthermore, using the theme skeleton of a conversation from which thematic densities are derived, it will be possible to extract components of an automatic conversation report to be used for improving the service performance. Index Terms: multi-topic audio document classification, hu-man/human conversation analysis, speech analytics, distance bigrams
description: arXiv admin note: text overlap with arXiv:1812.07207
Geometric Phase of a Transmon in a Dissipative Quantum Circuit
Creators: name: Viotti, Ludmila
name: Lombardo, Fernando C.
name: Villar, Paula I.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Quantum Physics (quant-ph)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Superconducting circuits reveal themselves as promising physical devices with multiple uses. Within those uses, the fundamental concept of the geometric phase accumulated by the state of a system shows up recurrently, as, for example, in the construction of geometric gates. Given this framework, we study the geometric phases acquired by a paradigmatic setup: a transmon coupled to a superconductor resonating cavity. We do so both for the case in which the evolution is unitary and when it is subjected to dissipative effects. These models offer a comprehensive quantum description of an anharmonic system interacting with a single mode of the electromagnetic field within a perfect or dissipative cavity, respectively. In the dissipative model, the non-unitary effects arise from dephasing, relaxation, and decay of the transmon coupled to its environment. Our approach enables a comparison of the geometric phases obtained in these models, leading to a thorough understanding of the corrections introduced by the presence of the environment.
description: 12 pages, 11 figures
On-Time Delivery in Crowdshipping Systems: An Agent-Based Approach Using Streaming Data
Creators: name: Dötterl, Jeremias
name: Bruns, Ralf
name: Dunkel, Jürgen
name: Ossowski, Sascha
Publisher: name: arXiv
Year: 2024
Subjects: subject: Artificial Intelligence (cs.AI)
subject: Machine Learning (cs.LG)
subject: Multiagent Systems (cs.MA)
subject: FOS: Computer and information sciences

description: In parcel delivery, the "last mile" from the parcel hub to the customer is costly, especially for time-sensitive delivery tasks that have to be completed within hours after arrival. Recently, crowdshipping has attracted increased attention as a new alternative to traditional delivery modes. In crowdshipping, private citizens ("the crowd") perform short detours in their daily lives to contribute to parcel delivery in exchange for small incentives. However, achieving desirable crowd behavior is challenging as the crowd is highly dynamic and consists of autonomous, self-interested individuals. Leveraging crowdshipping for time-sensitive deliveries remains an open challenge. In this paper, we present an agent-based approach to on-time parcel delivery with crowds. Our system performs data stream processing on the couriers' smartphone sensor data to predict delivery delays. Whenever a delay is predicted, the system attempts to forge an agreement for transferring the parcel from the current deliverer to a more promising courier nearby. Our experiments show that through accurate delay predictions and purposeful task transfers many delays can be prevented that would occur without our approach.
Spin relaxation of conduction electrons in polyvalent metals: A realistic calculation
Creators: name: Fabian, J.
name: Sarma, S. Das
Publisher: name: arXiv
Year: 1998
Subjects: subject: Condensed Matter (cond-mat)
subject: FOS: Physical sciences

description: Relaxation of electronic spins in metals is significantly enhanced whenever a Fermi surface crosses Brillouin zone boundaries, special symmetry points, or lines of accidental degeneracy. A realistic calculation shows that if aluminum had one valence electron, its spin relaxation would be slower by nearly two orders of magnitude. This not only solves a longstanding experimental puzzle, but also provides a way of tailoring spin dynamics of electrons in a conduction band.
description: 12 pages, 3 figures; to appear in PRL
Differentiation of integral Mittag-Leffler and integral Wright functions with respect to parameters
Creators: name: Apelblat, Alexander
name: González-Santander, Juan Luis
Publisher: name: arXiv
Year: 2024
Subjects: subject: Classical Analysis and ODEs (math.CA)
subject: FOS: Mathematics
subject: 33E12, 33C10, 33C20

description: Derivatives with respect to the parameters of the integral Mittag-Leffler function and the integral Wright function, recently introduced by us, are calculated. These derivatives can be expressed in the form of infinite sums of quotients of the digamma and gamma functions. In some particular cases, these infinite sums are calculated in closed-form with the help of MATHEMATICA. However, parameter differentiation reduction formulas are explicitly derived in order to check some of the results given by MATHEMATICA, as well as to provide many other new results. In addition, we present these infinite sums graphically for particular values of the parameters. Finally, new results for parameter derivatives of the Mittag-Leffler and Wright functions are reported in the Appendices.
Additional file 2: of Computational fluid dynamic analysis of physical forces playing a role in brain organoid cultures in two different multiplex platforms
Creators: name: Goto-Silva, Livia
name: Ayad, Nadia
name: Iasmin Herzog
name: Nilton Silva
name: Lamien, Bernard
name: Helcio Orlande
name: Souza, Annie Costa
name: Sidarta Ribeiro
name: Martins, Michele
name: Domont, Gilberto
name: Junqueira, Magno
name: Tovar-Moll, Fernanda
name: Stevens Rehen
Publisher: name: figshare
Year: 2019
Subjects: subject: Biophysics
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Developmental Biology
subject: Science Policy

description: Figure S2. CFD analysis of plates in an orbital shaker. Transient states were simulated until a quasi-steady-state regime was reached, when the flow became periodic. Liquid flow was analyzed at 0.5, 14 and 15â s after the start of the movement. (PDF 1067 kb)
Wellposedness and convergence of solutions to a class of forced non-diffusive equations with applications
Creators: name: Friedlander, Susan
name: Suen, Anthony
Publisher: name: arXiv
Year: 2019
Subjects: subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics
subject: 76D03, 35Q35, 76W05

description: This paper considers a family of non-diffusive active scalar equations where a viscosity type parameter enters the equations via the constitutive law that relates the drift velocity with the scalar field. The resulting operator is smooth when the viscosity is present but singular when the viscosity is zero. We obtain Gevrey-class local well-posedness results and convergence of solutions as the viscosity vanishes. We apply our results to two examples that are derived from physical systems: firstly a model for magnetostrophic turbulence in the Earth's fluid core and secondly flow in a porous media with an "effective viscosity".
title: Brouillon sur politique française au Liban
title: Draft about French politics in Lebanon
title: مسودة عن السياسية الفرنسية في لبنان
Creators: name: Seurat, Michel
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2019

description: Source: http://www.calames.abes.fr/pub/ms/FileId-2994
description: created: sine data
Electronic structure of full-shell InAs/Al hybrid semiconductor-superconductor nanowires: Spin-orbit coupling and topological phase space
Creators: name: Woods, Benjamin D.
name: Sarma, Sankar Das
name: Stanescu, Tudor D.
Publisher: name: arXiv
Year: 2019
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: We study the electronic structure of full-shell superconductor-semiconductor nanowires, which have recently been proposed for creating Majorana zero modes, using an eight-band $\vec{k} \cdot \vec{p}$ model within a fully self-consistent Schrödinger-Poisson scheme. We find that the spin-orbit coupling induced by the intrinsic radial electric field is generically weak for sub-bands with their minimum near the Fermi energy. Furthermore, we show that the chemical potential windows consistent with the emergence of a topological phase are small and sparse and can only be reached by fine tunning the diameter of the wire. These findings suggest that the parameter space consistent with the realization of a topological phase in full-shell InAs/Al nanowires is, at best, very narrow.
description: 5 pages, 4 figures + Supplemental Material
Additional file 1: of Effects of unaltered and bioconverted mulberry leaf extracts on cellular glucose uptake and antidiabetic action in animals
Creators: name: Jung, Sang-Hyuk
name: Joo-Hui Han
name: Park, Hyun-Soo
name: Lee, Do-Hyung
name: Kim, Seok
name: Cho, Hyun
name: Kang, Jong
name: Chang-Seon Myung
Publisher: name: figshare
Year: 2019
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified

description: The following information is available online: Grouping experimental animals by results of blood glucose levels and oral glucose tolerance test. (PDF 1658 kb)
Improving genetic algorithms performance via deterministic population shrinkage
Creators: name: Laredo, Juan Luis Jiménez
name: Fernandes, Carlos
name: Merelo, Juan Julián
name: Gagné, Christian
Publisher: name: arXiv
Year: 2024
Subjects: subject: Neural and Evolutionary Computing (cs.NE)
subject: FOS: Computer and information sciences

description: Despite the intuition that the same population size is not needed throughout the run of an Evolutionary Algorithm (EA), most EAs use a fixed population size. This paper presents an empirical study on the possible benefits of a Simple Variable Population Sizing (SVPS) scheme on the performance of Genetic Algorithms (GAs). It consists in decreasing the population for a GA run following a predetermined schedule, configured by a speed and a severity parameter. The method uses as initial population size an estimation of the minimum size needed to supply enough building blocks, using a fixed-size selectorecombinative GA converging within some confidence interval toward good solutions for a particular problem. Following this methodology, a scalability analysis is conducted on deceptive, quasi-deceptive, and non-deceptive trap functions in order to assess whether SVPS-GA improves performances compared to a fixed-size GA under different problem instances and difficulty levels. Results show several combinations of speed-severity where SVPS-GA preserves the solution quality while improving performances, by reducing the number of evaluations needed for success.
title: Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° ÐºÐ¾Ð¼Ð¿Ð¾Ð½ÐµÐ½ÑÐ¾Ð² ÑÐ¸ÑÑÐµÐ¼Ñ Ð¸Ð½ÑÐµÐ»Ð»ÐµÐºÑÑÐ°Ð»ÑÐ½Ð¾Ð³Ð¾ ÑÐ¿ÑÐ°Ð²Ð»ÐµÐ½Ð¸Ñ ÐºÐ¾ÑÐ»Ð¾Ð°Ð³ÑÐµÐ³Ð°ÑÐ¾Ð¼
title: Ð²ÑÐ¿ÑÑÐºÐ½Ð°Ñ ÐºÐ²Ð°Ð»Ð¸ÑÐ¸ÐºÐ°ÑÐ¸Ð¾Ð½Ð½Ð°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¼Ð°Ð³Ð¸ÑÑÑÐ°
titleType: Subtitle
title: Development of components of the boiler intelligent control system
Creators: name: ÐÐ¾ÑÐ¸ÑÐ¾Ð², ÐÐ²Ð³ÐµÐ½Ð¸Ð¹
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2024
Subjects: ÐÐ°ÑÐ¾Ð²ÑÐµ ÐºÐ¾ÑÐ»Ñ
ÑÐµÐ¼Ð°Ð½ÑÐ¸ÑÐµÑÐºÐ°Ñ Ð¸Ð½ÑÐµÑÐ¾Ð¿ÐµÑÐ°Ð±ÐµÐ»ÑÐ½Ð¾ÑÑÑ
Ð¾Ð½ÑÐ¾Ð»Ð¾Ð³Ð¸Ð¸
ÐºÐ¾ÑÐ»Ð¾Ð°Ð³ÑÐµÐ³Ð°Ñ
Ð±Ð°Ð·Ð° Ð·Ð½Ð°Ð½Ð¸Ð¹
semantic interoperability
ontologies
boiler
knowledge base

description: ÐÐ°Ð½Ð½Ð°Ñ Ð¼Ð°Ð³Ð¸ÑÑÐµÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ° Ð¿Ð¾ÑÐ²ÑÑÐµÐ½Ð° Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸Ñ ÑÐµÐ¼Ð°Ð½ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð¸Ð½ÑÐµÑÐ¾Ð¿ÐµÑÐ°Ð±ÐµÐ»ÑÐ½Ð¾ÑÑÐ¸ Ð´Ð»Ñ Ð¿Ð¾Ð²ÑÑÐµÐ½Ð¸Ñ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ ÑÐºÑÐ¿Ð»ÑÐ°ÑÐ°ÑÐ¸Ð¸ ÐºÐ¾ÑÐ»Ð¾Ð°Ð³ÑÐµÐ³Ð°ÑÐ°. ÐÐ°Ð´Ð°ÑÐ¸, ÑÐµÑÐ°ÐµÐ¼ÑÐµ Ð² ÑÐ¾Ð´Ðµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ñ: Ð¸Ð·ÑÑÐµÐ½Ð¸Ðµ ÑÑÑÐµÑÑÐ²ÑÑÑÐ¸Ñ Ð¾Ð½ÑÐ¾Ð»Ð¾Ð³Ð¸Ð¹ Ð² ÑÑÐµÑÐµ ÑÐµÐ¿Ð»Ð¾ÑÐ½ÐµÑÐ³ÐµÑÐ¸ÐºÐ¸, Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¾Ð½ÑÐ¾Ð»Ð¾Ð³Ð¸ÑÐµÑÐºÐ¾Ð³Ð¾ Ð¼ÐµÑÐ¾Ð´Ð° Ð¾Ð±ÐµÑÐ¿ÐµÑÐµÐ½Ð¸Ñ ÑÐµÐ¼Ð°Ð½ÑÐ¸ÑÐµÑÐºÐ¾Ð¹ Ð¸Ð½ÑÐµÑÐ¾Ð¿ÐµÑÐ°Ð±ÐµÐ»ÑÐ½Ð¾ÑÑÐ¸, pÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ° Ð¿ÑÐ¸Ð»Ð¾Ð¶ÐµÐ½Ð¸Ñ. ÐÑÐ»Ð¸ ÑÐ°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ñ ÑÐ¿Ð¾ÑÐ¾Ð±Ñ Ð½Ð°Ð¸Ð±Ð¾Ð»ÐµÐµ ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾Ð¹ ÑÐµÐ°Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¿ÑÐ¸Ð»Ð¾Ð¶ÐµÐ½Ð¸Ñ, ÐºÐ¾ÑÐ¾ÑÐ¾Ðµ Ð¾Ð±ÐµÑÐ¿ÐµÑÐ¸Ð²Ð°ÐµÑ ÑÐµÐ¼Ð°Ð½ÑÐ¸ÑÐµÑÐºÑÑ Ð¸Ð½ÑÐµÑÐ¾Ð¿ÐµÑÐ°Ð±ÐµÐ»ÑÐ½Ð¾ÑÑÑ, Ð¸ Ð²Ð¾Ð·Ð¼Ð¾Ð¶Ð½Ð¾ÑÑÑ ÐµÐ³Ð¾ ÑÐ°Ð·ÑÐ°Ð±Ð¾ÑÐºÐ¸. Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ð° Ð¾Ð½ÑÐ¾Ð»Ð¾Ð³Ð¸Ñ Ð² Ð¸Ð½ÑÑÑÑÐ¼ÐµÐ½ÑÐ°Ð»ÑÐ½Ð¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ðµ ProtÃ©gÃ© Ð¸ Ð´Ð²Ð° Ð¿ÑÐ¸Ð»Ð¾Ð¶ÐµÐ½Ð¸Ñ Ð´Ð»Ñ Ð¾Ð±ÑÐ°Ð±Ð¾ÑÐºÐ¸ Ð¸ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° Ð´Ð°Ð½Ð½ÑÑ Ð² ÑÐ¾Ð¾ÑÐ²ÐµÑÑÑÐ²Ð¸Ð¸ Ñ Ð¾Ð½ÑÐ¾Ð»Ð¾Ð³Ð¸ÐµÐ¹ Ð½Ð° ÑÐ·ÑÐºÐ°Ñ Ð² ÑÐ¸ÑÑÐµÐ¼Ðµ Matlab Ð¸ C# Ñ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸ÐµÐ¼ Ð±Ð¸Ð±Ð»Ð¸Ð¾ÑÐµÐºÐ¸ dotNetRDF.
description: This masters thesis is devoted to the study of the use of semantic interoperability to improve the efficiency of boiler operation. The tasks to be solved during the research: the study of existing ontologies in the field of thermal power engineering, the study of the ontological method of ensuring semantic interoperability, the development of an application. The ways of the most effective implementation of the application, which provides semantic interoperability, and the possibility of its development were considered. An ontology has been developed in the ProtÃ©gÃ© tool system and two applications for data processing and analysis in accordance with the ontology in Matlab and C# languages using the dotNetRDF library.
The Murchison Widefield Array Transients Survey (MWATS). A search for low frequency variability in a bright Southern hemisphere sample
Creators: name: Bell, M. E.
name: Murphy, Tara
name: Hancock, P. J.
name: Callingham, J. R.
name: Johnston, S.
name: Kaplan, D. L.
name: Hunstead, R. W.
name: Sadler, E. M.
name: Croft, S.
name: White, S. V.
name: Hurley-Walker, N.
name: Chhetri, R.
name: Morgan, J. S.
name: Edwards, P. G.
name: Rowlinson, A.
name: Offringa, A. R.
name: Bernardi, G.
name: Bowman, J. D.
name: Briggs, F.
name: Cappallo, R. J.
name: Deshpande, A. A.
name: Gaensler, B. M.
name: Greenhill, L. J.
name: Hazelton, B. J.
name: Johnston-Hollitt, M.
name: Lonsdale, C. J.
name: McWhirter, S. R.
name: Mitchell, D. A.
name: Morales, M. F.
name: Morgan, E.
name: Oberoi, D.
name: Ord, S. M.
name: Prabu, T.
name: Shankar, N. Udaya
name: Srivani, K. S.
name: Subrahmanyan, R.
name: Tingay, S. J.
name: Wayth, R. B.
name: Webster, R. L.
name: Williams, A.
name: Williams, C. L.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We report on a search for low-frequency radio variability in 944 bright (> 4Jy at 154 MHz) unresolved, extragalactic radio sources monitored monthly for several years with the Murchison Widefield Array. In the majority of sources we find very low levels of variability with typical modulation indices < 5%. We detect 15 candidate low frequency variables that show significant long term variability (>2.8 years) with time-averaged modulation indices M = 3.1 - 7.1%. With 7/15 of these variable sources having peaked spectral energy distributions, and only 5.7% of the overall sample having peaked spectra, we find an increase in the prevalence of variability in this spectral class. We conclude that the variability seen in this survey is most probably a consequence of refractive interstellar scintillation and that these objects must have the majority of their flux density contained within angular diameters less than 50 milli-arcsec (which we support with multi-wavelength data). At 154 MHz we demonstrate that interstellar scintillation time-scales become long (~decades) and have low modulation indices, whilst synchrotron driven variability can only produce dynamic changes on time-scales of hundreds of years, with flux density changes less than one milli-jansky (without relativistic boosting). From this work we infer that the low frequency extra-galactic southern sky, as seen by SKA-Low, will be non-variable on time-scales shorter than one year.
description: 19 pages, 11 figures
title: Datura wrightii
title: Version 1
titleType: Subtitle
Creators: name: The Information Contained In This Species Profile Was Provided By The Council Of Heads Of Australasian Herbaria (CHAH) To The Department Of Sustainability, Environment, Water, Population And Communities In August 2007, Updated In December 2011.
Publisher: name: WEEDS AUSTRALIA - profiles
Year: 2021
Subjects: Datura wrightii

description: Taxonomic treatment for Datura wrightii
Monte Carlo simulation of GaAs(001) homoepitaxy
Creators: name: Itoh, M.
name: Bell, G. R.
name: Joyce, B. A.
name: Vvedensky, D. D.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: By carrying out Monte Carlo simulations based on the two-species atomic-scale kinetic growth model of GaAs(001) homoepitaxy and comparing the results with scanning tunneling microscope images, we show that initial growing islands undergo the structural transformation before adopting the proper beta2(2x4) reconstruction.
description: 6 pages, 7 figures, talk given at 5th International Conference on Computational Physics (Kanazawa, Japan, 1999). Progress of Theoretical Physics, Supplement, to appear. Related articles can be found at http://wwwacty.phys.sci.osaka-u.ac.jp/~makoto/
Phonon-assisted tunneling in asymmetric resonant tunneling structures
Creators: name: Shi, Jun-jie
name: Sanders, Barry C.
name: Pan, Shao-hua
Publisher: name: arXiv
Year: 1998
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Based on the dielectric continuum model, we calculated the phonon assisted tunneling (PAT) current of general double barrier resonant tunneling structures (DBRTSs) including both symmetric and antisymmetric ones. The results indicate that the four higher frequency interface phonon modes (especially the one which peaks at either interface of the emitter barrier) dominate the PAT processes, which increase the valley current and decrease the PVR of the DBRTSs. We show that an asymmetric structure can lead to improved performance.
description: 1 paper and 5 figures
title: Was bedeuten Versorgungsübergänge im letzten Lebensjahr für Patient*innen und Nahestehende? Ein sequenzielles Mixed-Methods-Vertiefungsdesign
Creators: name: Schippel, Nicolas
name: Hanke, Gloria
name: Rietz, Christian
name: Strupp, Julia
name: Voltz, Raymond
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Das letzte Lebensjahr von Patient*innen ist häufig von komplexen Behandlungsbedürfnissen und einer Vielzahl von involvierten Versorgenden gekennzeichnet. Es finden vermehrt Übergänge zwischen Versorgungsorten statt, die eine Diskontinuität im Versorgungsverlauf[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 18. Deutscher Kongress für Versorgungsforschung (DKVF)
Facilitating the Manual Annotation of Sounds When Using Large Taxonomies
Creators: name: Favory, Xavier
name: Fonseca, Eduardo
name: Font, Frederic
name: Serra, Xavier
Publisher: name: arXiv
Year: 2018
Subjects: subject: Information Retrieval (cs.IR)
subject: Human-Computer Interaction (cs.HC)
subject: Machine Learning (cs.LG)
subject: Sound (cs.SD)
subject: Audio and Speech Processing (eess.AS)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: Properly annotated multimedia content is crucial for supporting advances in many Information Retrieval applications. It enables, for instance, the development of automatic tools for the annotation of large and diverse multimedia collections. In the context of everyday sounds and online collections, the content to describe is very diverse and involves many different types of concepts, often organised in large hierarchical structures called taxonomies. This makes the task of manually annotating content arduous. In this paper, we present our user-centered development of two tools for the manual annotation of audio content from a wide range of types. We conducted a preliminary evaluation of functional prototypes involving real users. The goal is to evaluate them in a real context, engage in discussions with users, and inspire new ideas. A qualitative analysis was carried out including usability questionnaires and semi-structured interviews. This revealed interesting aspects to consider when developing tools for the manual annotation of audio content with labels drawn from large hierarchical taxonomies.
description: 5 pages, 5 figures, IEEE FRUCT International Workshop on Semantic Audio and the Internet of Things
title: Datura wrightii
title: Version 2
titleType: Subtitle
Creators: name: The Information Contained In This Species Profile Was Provided By The Council Of Heads Of Australasian Herbaria (CHAH) To The Department Of Sustainability, Environment, Water, Population And Communities In August 2007, Updated In December 2011 And Subsequently In June 2021.
Publisher: name: WEEDS AUSTRALIA - profiles
Year: 2021
Subjects: Datura wrightii

description: Taxonomic treatment for Datura wrightii
On the Effectiveness of Observations in the Mid-Infrared Wavelength Range on the 2.5-Meter Telescope of the Caucasus Mountain Observatory of Moscow State University with Commercial IR Cameras
Creators: name: Zheltoukhov, S. G.
name: Tatarnikov, A. M.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Instrumentation and Methods for Astrophysics (astro-ph.IM)
subject: FOS: Physical sciences

description: The main factors that influence the success of observations in the infrared range (central wavelengths of the photometric bands at 3.75 and 4.8~$μ$m) on the multipurpose optical telescope are considered. Estimates of the sky background brightness are obtained for the Caucasus Mountain Observatory (CMO) of Moscow State University: $1.3\cdot10^6$~photons/(s pixel) in the 3.75~$μ$m band and $3.4\cdot10^6$~photons/(s pixel) in the 4.8~$μ$m; and the instrumental background for the 2.5-m CMO telescope at $0^\circ$C: $3.2\cdot10^6$~photons/(s pixel) in the 3.75~$μ$m band and $4.3\cdot10^6$~photons/(s pixel) in the 4.8~$μ$m band. It is shown that at this background signal level with the currently available commercial cameras in the $3-5$~$μ$m spectral range, the telescope-camera coupling capabilities for observing faint objects will still be limited by the thermal background. For different observational conditions, estimates of the limiting magnitudes of objects available for observations in the 3.75 and 4.8~$μ$m ranges are obtained. For average observation conditions (instrument temperature of $0^\circ$C and stellar image size of 1 arcsec), the limit is $\sim10.6^m$ and $\sim8.4^m$, respectively.
description: 16 pages, 7 figures
Boundary integrable quantum field theories
Creators: name: Dorey, Patrick
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: A brief survey of recent results in the study of boundary integrable quantum field theories, indicating some currently open problems. Based on lectures given at the 2000 Eotvos Summer School in Physics on `Nonperturbative QFT methods and their applications'.
description: 6 pages, Latex, uses sprocl, cite, amssymb
title: Letztes Lebensjahr: Krankenhausversorgung ist zentraler Einflussfaktor auf die Unzufriedenheit
Creators: name: Hanke, Gloria
name: Schippel, Nicolas
name: Rietz, Christian
name: Voltz, Raymond
name: Strupp, Julia
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Die häufig komplexen und multidimensionalen Bedarfs- und Problemlagen von Patient*innen im letzten Lebensjahr führen zu einer erhöhten Inanspruchnahme von Versorgungsleistungen verschiedener Professionen und Versorgungsstrukturen. Die subjektiven Erfahrungen, die Patient*innen[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 18. Deutscher Kongress für Versorgungsforschung (DKVF)
The Kalman-Levy filter
Creators: name: Sornette, D.
name: Ide, K.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: The Kalman filter combines forecasts and new observations to obtain an estimation which is optimal in the sense of a minimum average quadratic error. The Kalman filter has two main restrictions: (i) the dynamical system is assumed linear and (ii) forecasting errors and observational noises are taken Gaussian. Here, we offer an important generalization to the case where errors and noises have heavy tail distributions such as power laws and Lévy laws. The main tool needed to solve this ``Kalman-Lévy'' filter is the ``tail-covariance'' matrix which generalizes the covariance matrix in the case where it is mathematically ill-defined (i.e. for power law tail exponents $μ\leq 2$). We present the general solution and discuss its properties on pedagogical examples. The standard Kalman-Gaussian filter is recovered for the case $μ= 2$. The optimal Kalman-Lévy filter is found to deviate substantially fro the standard Kalman-Gaussian filter as $μ$ deviates from 2. As $μ$ decreases, novel observations are assimilated with less and less weight as a small exponent $μ$ implies large errors with significant probabilities. In terms of implementation, the price-to-pay associated with the presence of heavy tail noise distributions is that the standard linear formalism valid for the Gaussian case is transformed into a nonlinear matrice equation for the Kalman-Lévy filter. Direct numerical experiments in the univariate case confirms our theoretical predictions.
description: 41 pages, 9 figures, correction of errors in the general multivariate case
title: Versorgungsverläufe im letzten Lebensjahr und Hinweise auf die Zielerreichung ambulanter palliativer Versorgung. Eine Auswertung regionaler GKV-Routinedaten
Creators: name: Meyer, Ingo
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Hintergrund: Die SAPV [ref:1] zielt auf die Verbesserung der Versorgung unheilbar Kranker am Lebensende und umfasst medizinische und pflegerische Leistungen, Koordination und Beratung von Betroffenen. Ihre Ziele sind die Förderung von Lebensqualität und Selbstbestimmung schwerstkranker[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 18. Deutscher Kongress für Versorgungsforschung (DKVF)
title: The Robson Classification for Caesarean Section – Routinely Collected Health Data at a Swiss Tertiary Care Center from 2014 to 2017: Evaluating Clinical Homogeneity, Case Related Costs and Swiss DRG Reimbursement
Creators: name: Triep, Karen
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Background: With an increasing rate of caesarean sections (CS) as well as rising numbers of multiple pregnancies, valid classifications are needed. Benchmarking with regard to the CS rate and outcome is only possible, if a commonly accepted classification is established. The Robson classification provides[for full text, please go to the a.m. URL]
description: 18. Deutscher Kongress für Versorgungsforschung (DKVF)
Review on the Role of GNSS Meteorology in Monitoring Water Vapor for Atmospheric Physics
Creators: name: Vaquero-Martinez, Javier
name: Anton, Manuel
Publisher: name: arXiv
Year: 2024
Subjects: subject: Atmospheric and Oceanic Physics (physics.ao-ph)
subject: FOS: Physical sciences

description: After 30 years since the beginning of the Global Positioning System (GPS), or, more generally, Global Navigation Satellite System (GNSS) meteorology, this technique has proven to be a reliable method for retrieving atmospheric water vapor; it is low-cost, weather independent, with high temporal resolution and is highly accurate and precise. GNSS ground-based networks are becoming denser, and the first stations installed have now quite long time-series that allow the study of the temporal features of water vapor and its relevant role inside the climate system. In this review, the different GNSS methodologies to retrieve atmospheric water vapor content re-examined, such as tomography, conversion of GNSS tropospheric delay to water vapor estimates, analyses of errors, and combinations of GNSS with other sources to enhance water vapor information. Moreover, the use of these data in different kinds of studies is discussed. For instance, the GNSS technique is commonly used as a reference tool for validating other water vapor products (e.g., radiosounding, radiometers onboard satellite platforms or ground-based instruments). Additionally, GNSS retrievals are largely used in order to determine the high spatio-temporal variability and long-term trends of atmospheric water vapor or in models with the goal of determining its notable influence on the climate system (e.g., assimilation in numerical prediction, as input to radiative transfer models, study of circulation patterns, etc.
description: 29 pages, 3 figures
Measurement of the impact of turbulence anisoplanatism on precision free-space optical time transfer
Creators: name: Swann, W. C.
name: Bodine, M. I.
name: Khader, I.
name: Deschenes, J. -D.
name: Baumann, E.
name: Sinclair, L. C.
name: Newbury, N. R.
Publisher: name: arXiv
Year: 2018
Subjects: subject: Optics (physics.optics)
subject: Applied Physics (physics.app-ph)
subject: FOS: Physical sciences

description: Future free-space optical clock networks will require optical links for time and frequency transfer. In many potential realizations of these networks, these links will extend over long distances and will span moving platforms, e.g. ground-to-air or ground-to-satellite. In these cases, the transverse platform motion coupled with spatial variations in atmospheric optical turbulence will lead to a breakdown in the time-of-flight reciprocity upon which optical two-way time-frequency transfer is based. Here, we report experimental measurements of this effect by use of comb-based optical two-way time-frequency transfer over two spatially separated optical links. We find only a modest degradation in the time synchronization and frequency syntonization between two sites, in good agreement with theory. Based on this agreement, we can extrapolate this 2-km result to longer distances, finding only a few-femtosecond timing noise increase due to turbulence for a link from ground to a mid-earth orbit satellite.
Additional file 1: of Computational fluid dynamic analysis of physical forces playing a role in brain organoid cultures in two different multiplex platforms
Creators: name: Goto-Silva, Livia
name: Ayad, Nadia
name: Iasmin Herzog
name: Nilton Silva
name: Lamien, Bernard
name: Helcio Orlande
name: Souza, Annie Costa
name: Sidarta Ribeiro
name: Martins, Michele
name: Domont, Gilberto
name: Junqueira, Magno
name: Tovar-Moll, Fernanda
name: Stevens Rehen
Publisher: name: figshare
Year: 2019
Subjects: Biophysics
Biochemistry
Cell Biology
Neuroscience
Biotechnology
Developmental Biology

description: Figure S1. Effect of ROCKi treatment and centrifugation at EB formation step. A. Changes in cell morphology were observed during cell counting. 10 μM iROCK treatment at dissociation step preserves cell membrane smoothness and prevents blebbing. Arrowheads: cell membranes. B. Effect of centrifugation on cell aggregation. Bars: 2000 μm. C. Measured circularity based on organoid morphology with and without centrifugation step; n = 8 for one independent test for the condition without centrifugation and n > =12 for two independent tests for the condition with centrifugation. D. Comparison of area of organoids with and without centrifugation at day 1 and day 10. (PDF 10252 kb)
title: Analyse der leitliniengerechten Versorgung von Kindern und Jugendlichen mit chronisch entzündlichen Darmerkrankungen
Creators: name: Görsch, Melanie
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Universitätsmedizin Greifswald, Institut für Community Medicine, Abteilung Versorgungsepidemiologie und Community HealthArt der Arbeit: Kumulative DissertationTitel: Analyse der leitliniengerechten Versorgung von Kindern und Jugendlichen mit chronisch entzündlichen DarmerkrankungenBeginn:[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 18. Deutscher Kongress für Versorgungsforschung (DKVF)
Scaling Dimensions of Lattice Quantized Gravity
Creators: name: Hamber, H. W.
Publisher: name: arXiv
Year: 2001
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: I discuss a model for quantized gravitation based on the simplicial lattice discretization. It has been studied in some detail using a comprehensive finite size scaling analysis combined with renormalization group methods. The results are consistent with a value for the universal critical exponent for gravitation $ν=1/3$, and suggest a simple relationship between Newton's constant, the gravitational correlation length and the observable average space-time curvature. Some perhaps testable phenomenological implications are discussed, such as the scale dependence of Newton's constant and properties of quantum curvature fluctuations.
description: Talk presented at the 9-th Marcel Grossman Meeting (LaTeX, 10 pages)
title: Implementation einer Regionalen Digitalen Fallakte in der Geriatrie (ReDiFa) unter Berücksichtigung des Community-Based Participatory Research (CBPR)-Ansatzes
Creators: name: Pfeuffer, Nils
Publisher: name: German Medical Science GMS Publishing House
Year: 2019
Subjects: subject: 610 Medical sciences; Medicine

description: Letzter Abschluss: M. Sc. Health Care ManagementArt der Arbeit: Kumulative DissertationBeginn: 01.11.2018(Geplanter) Abschluss: 31.03.2021 Hintergrund: Geriatrische Patienten zeichnen sich durch eine altersbedingte Vulnerabilität, Multimorbidität und ein erhöhtes Chronifizierungsrisiko[zum vollständigen Text gelangen Sie über die oben angegebene URL]
description: 18. Deutscher Kongress für Versorgungsforschung (DKVF)
Soluble Epoxide Hydrolase Deletion Attenuated Nicotine-induced Arterial Stiffness via Limiting the Loss of SIRT1
Creators: name: hu, shuiqing
name: Luo, Jinlan
name: Fu, Menglu
name: Luo, Liman
name: Cai, Yueting
name: Li, Wenhua
name: Li, Yuanyuan
name: Dong, Ruolan
name: Yang, Yan
name: Tu, Ling
name: Xu, Xizhen
Publisher: name: figshare
Year: 2021
Subjects: Cardiology

description: Arterial stiffness, a consequence of smoking, is an underlying risk factor of cardiovascular diseases. Epoxyeicosatrienoic acids (EETs), hydrolyzed by soluble epoxide hydrolase (sEH), have beneficial effects against vascular dysfunction. However, the role of sEH knockout in nicotine-induced arterial stiffness was not characterized. We hypothesized that sEH knockout could prevent nicotine-induced arterial stiffness. In the present study, Ephx2 (the gene encodes sEH enzyme) null (Ephx2-/-) mice and wild-type (WT) littermate mice were infused with or without nicotine and administered with or without nicotinamide (NAM, SIRT1 inhibitor) simultaneously for four weeks. Nicotine treatment increased sEH expression and activity in the aortas of WT mice. Nicotine infusion significantly induced vascular remodeling, arterial stiffness, and SIRT1 deactivation in WT mice, which was attenuated in Ephx2-/- mice without NAM treatment. However, the arterial protective effects were gone in Ephx2-/- mice with NAM treatment. In vitro, 11,12-EET treatment attenuated nicotine-induced MMP2 upregulation via SIRT1-mediated YAP deacetylation. In conclusion, sEH knockout attenuated nicotine-induced arterial stiffness and vascular remodeling via SIRT1-induced YAP deacetylation.