cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Genetic basis of falling risk susceptibility in the UK Biobank Study
Creators: name: Trajanoska, Katerina
name: Seppala, Lotta J.
name: Medina-Gomez, Carolina
name: Hsu, Yi-Hsiang
name: Zhou, Sirui
name: Van Schoor, Natasja M.
name: De Groot, Lisette C. P. G. M.
name: Karasik, David
name: Richards, J. Brent
name: Kiel, Douglas P.
name: Uitterlinden, Andre G.
name: Perry, John R. B.
name: Van Der Velde, Nathalie
name: Day, Felix R.
name: Rivadeneira, Fernando
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Article
/631/208/205
/692/499
/45/43
article

description: Abstract: Both extrinsic and intrinsic factors predispose older people to fall. We performed a genome-wide association analysis to investigate how much of an individual’s fall susceptibility can be attributed to genetics in 89,076 cases and 362,103 controls from the UK Biobank Study. The analysis revealed a small, but significant SNP-based heritability (2.7%) and identified three novel fall-associated loci (Pcombined ≤ 5 × 10−8). Polygenic risk scores in two independent settings showed patterns of polygenic inheritance. Risk of falling had positive genetic correlations with fractures, identifying for the first time a pathway independent of bone mineral density. There were also positive genetic correlations with insomnia, neuroticism, depressive symptoms, and different medications. Negative genetic correlations were identified with muscle strength, intelligence and subjective well-being. Brain, and in particular cerebellum tissue, showed the highest gene expression enrichment for fall-associated variants. Overall, despite the highly heterogenic nature underlying fall risk, a proportion of the susceptibility can be attributed to genetics.
title: Quels liens peut-on relever à travers des traces d'étudiants de première année issues d'un dispositif d'un module à la HEPL et les résultats qu'ils ont obtenus à l'examen semestriel ?
title: Quels liens peut-on relever à travers des traces d'étudiants de première année issues d'un dispositif d'un module à la HEPL et les résultats qu'ils ont obtenus à l'examen semestriel ?
titleType: AlternativeTitle
Creators: name: Abreu De Nobrega, Eléa
Publisher: name: Unknown
Year: 0
Subjects: subject: Enseignement supérieur
subject: dispositifs d’accompagnement
subject: résultats
subject: examen
subject: réussite / échec

description: L’enseignement supérieur a subi de nombreux changements durant ces dernières décennies. Il s’efforce de changer son mode de fonctionnement, dit traditionnel, afin de pouvoir répondre aux besoins actuels. Parmi ces derniers, nous retrouvons notamment l’augmentation du nombre d’étudiants. Ainsi, face à ces nouveaux enjeux, université, haute école et autres institutions appartenant à ce degré d’enseignement, se doivent de garantir la qualité de leurs offres d’enseignement. De ce fait, de nombreux dispositifs ou cellules de ressources pédagogiques ont vu le jour dans le but de favoriser la réussite des étudiants. C’est un défi auquel la haute école pédagogique de Lausanne a également dû relever. En effet, nous nous sommes intéressés à un module, donné lors du premier semestre de première année, qui a dû répondre au nombre grandissant d’étudiants. Il est vrai que pour les formateurs de ce module il ne devenait plus possible de corriger toutes ces copies. De ce fait, les modalités de l’examen ont été modifiées et ce dernier a pris la forme d’un QCM. Ils ont alors mis en place un dispositif, soit la production de synthèses (facultatif et hebdomadaire) afin d’accompagner les étudiants durant le semestre et leur permettre de mieux appréhender leur examen semestriel. Il s’agit alors de comprendre le fonctionnement d’un tel dispositif afin tisser des liens entre ce dernier et la réussite/l’échec d’un examen et ainsi de pouvoir y apporter des modifications en vue de le perfectionner.
Long-Term Spectral Variations of Ultraluminous X-ray Sources in the Interacting Galaxy Systems M51 and NGC4490/85
Creators: name: Yoshida, Tessei
name: Ebisawa, Ken
name: Matsushita, Kyoko
name: Tsujimoto, Masahiro
name: Kawaguchi, Toshihiro
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: Variable ultraluminous X-ray sources (ULXs), which are considered to be black hole binaries (BHBs), are known to show state transitions similarly to Galactic BHBs. However, the relation between the ULX states and the Galactic BHB states is still unclear primarily due to less well-understood behaviors of ULXs in contrast to the Galactic BHBs. Here, we report a statistical X-ray spectral study of 34 energy spectra from seven bright ULXs in the interacting galaxy systems M51 and NGC4490/85, using archive data from multiple Chandra and XMM-Newton observations spanning for a few years. In order to compare with Galactic BHB states, we applied representative spectral models of BHBs; a power-law (PL), a multi-color disk black body (MCD), and a slim disk model to all the ULX spectra. We found a hint of a bimodal structure in the luminosity distribution of the samples, suggesting that ULXs have two states with typical luminosities of 3-6*10^{39} and 1.5-3*10^{39} ergs/s. Most spectra in the brighter state are explained by the MCD or the slim disk model, whereas those in the fainter state are explained by the PL model. In particular, the slim disk model successfully explains the observed spectral variations of NGC4490/85 ULX-6 and ULX-8 by changes of the mass accretion rate to a black hole of an estimated mass of <40 Msun. From the best-fit model parameters of each state, we speculate that the brighter state in these two ULXs corresponds to the brightest state of Galactic BHBs, which is often called the ``apparently standard state''. The fainter state of the ULXs has a PL shaped spectrum, but the photon index range is much wider than that seen in any single state of Galactic BHBs. We thus speculate that it is a state unique to ULXs. Some sources show much fainter and steeper spectra than the faint state, which we identified as another state.
description: 14 pages, 8 figures, accepted for publication in ApJ
Additional file 1 of Effect of a curriculum transformation on pharmacy student self-efficacy, self-reported activities, and satisfaction in degree and career choice
Creators: name: Singh, Harjit Kaur
name: Lyons, Kayley Marie
name: Brock, Tina Penick
name: Malone, Daniel Thomas
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Science Policy

description: Supplementary Material 1
Many-body effects in van der Waals-Casimir interaction between graphene layers
Creators: name: Sarabadani, Jalal
name: Naji, Ali
name: Asgari, Reza
name: Podgornik, Rudolf
Publisher: name: arXiv
Year: 2011
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Van der Waals-Casimir dispersion interactions between two apposed graphene layers, a graphene layer and a substrate, and in a multilamellar graphene system are analyzed within the framework of the Lifshitz theory. This formulation hinges on a known form of the dielectric response function of an undoped or doped graphene sheet, assumed to be of a random phase approximation form. In the geometry of two apposed layers the separation dependence of the van der Waals-Casimir interaction for both types of graphene sheets is determined and compared with some well known limiting cases. In a multilamellar array the many-body effects are quantified and shown to increase the magnitude of the van der Waals-Casimir interactions.
description: 13 pages, 13 figures
Comparison of putative BH3 mimetics AT-101, HA14-1, sabutoclax and TW-37 with ABT-737 in platelets
Creators: name: Wei, Hao
name: Harper, Matthew T.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Pharmacology
subject: Cancer
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Platelet lifespan is regulated by intrinsic apoptosis. Platelet apoptosis can be triggered by BH3 mimetics that inhibit the pro-survival Bcl-2 family protein, Bcl-xL. Here, we investigated several small molecules that are reported to act as BH3 mimetics and compared their effects to the well-established BH3 mimetic, ABT-737. Platelet phosphatidylserine (PS) exposure was determined by flow cytometry. Changes in cytosolic Ca2+ signaling were detected using Cal-520. Plasma membrane integrity was determined by calcein leakage. The roles of caspases and calpain in these processes were determined using Q-VD-OPh and calpeptin, respectively. As previously reported, ABT-737 triggered PS exposure in a caspase-dependent manner and calcein loss in a caspase and calpain-dependent manner. In contrast, AT-101 and sabutoclax triggered PS exposure independently of caspases. HA14-1 also triggered PS exposure in a caspase-independent but calpain-dependent manner. There were also significant differences in the pattern and protease-dependency of cytosolic Ca2+ signaling in response to these drugs compared to ABT-737. Since there are clear differences between the action of ABT-737 and the other putative BH3 mimetics investigated here, AT-101, HA14-1 and sabutoclax cannot be considered as acting as BH3 mimetics in platelets. Furthermore, the platelet death caused by these drugs is likely to be distinct from apoptosis.
Sick with sugar : the sociocultural dimensions of managing diabetes in a semi-urban Indian Trinidadian community
Creators: name: Parmasad, Vishala
Publisher: name: University of British Columbia
Year: 2019

description: This dissertation comprises ethnographies and narratives of the ways in which Indian Trinidadians in Debe, Trinidad negotiated their life-worlds, life-course expectations, and ethnic identities around Type 2 diabetes mellitus with family, food, and religion as central themes. In overview, this research explores how Type 2 diabetes mellitus, popularly known as “sugar”, is constructed and responded to, as well as the impact of inequities in access to healthcare on people’s ability to manage this disease. Diabetes is the second most common cause of death in Trinidad and Tobago, and has highest estimated prevalence among Indian Trinidadians. Much of the discourse in Trinidad blames high local rates of Type 2 diabetes mellitus-associated mortality and morbidity on unhealthy patient practices and lifestyles. Through participant observation, interviews, and archival research, I explored normative biomedical notions of disease and untangled who is affected by a diabetes diagnosis, how they are affected, and what they do when their lives change, or to change their lives in this context. This research revealed some ways in which overly simplistic notions of patient autonomy projected upon complex, enmeshed societies and polities can be translated as ineffective recommendations for disease management, producing unintended and detrimental changes to people’s life-worlds. Understanding diabetes and its management in Debe required not only understanding the pathological or biological disease process, but more crucially, the explanatory models of people with this diagnosis, how they coped with associated illness, and the crucial communities of care that facilitated therapeutic efforts. Particularly important were narratives of persons with diagnosis of diabetes, and their caregivers. The case narratives produced are grounded in the ethnography of an economically heterogeneous community that has undergone many transitions in the recent past, including the rise in the rates of diabetes and resultant transformations of everyday socialities. These stories are therefore also inherently concerned with temporality on different scales: the progression of a disease over time, the changes in an individual life course over time, and the temporal shifts in a community as it moves from a shared, agricultural past to an uncertain and multitudinous future.
A flowing plasma model to describe drift waves in a cylindrical helicon discharge
Creators: name: Chang, L.
name: Hole, M. J.
name: Cormac, C. S.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: A two-fluid model developed originally to describe wave oscillations in the vacuum arc centrifuge, a cylindrical, rapidly rotating, low temperature and confined plasma column, is applied to interpret plasma oscillations in a RF generated linear magnetised plasma (WOMBAT), with similar density and field strength. Compared to typical centrifuge plasmas, WOMBAT plasmas have slower normalised rotation frequency, lower temperature and lower axial velocity. Despite these differences, the two-fluid model provides a consistent description of the WOMBAT plasma configuration and yields qualitative agreement between measured and predicted wave oscillation frequencies with axial field strength. In addition, the radial profile of the density perturbation predicted by this model is consistent with the data. Parameter scans show that the dispersion curve is sensitive to the axial field strength and the electron temperature, and the dependence of oscillation frequency with electron temperature matches the experiment. These results consolidate earlier claims that the density and floating potential oscillations are a resistive drift mode, driven by the density gradient. To our knowledge, this is the first detailed physics model of flowing plasmas in the diffusion region away from the RF source. Possible extensions to the model, including temperature non-uniformity and magnetic field oscillations, are also discussed.
Recovering Grammar Relationships for the Java Language Specification
Creators: name: Lämmel, Ralf
name: Zaytsev, Vadim
Publisher: name: arXiv
Year: 2010
Subjects: subject: Programming Languages (cs.PL)
subject: FOS: Computer and information sciences

description: Grammar convergence is a method that helps discovering relationships between different grammars of the same language or different language versions. The key element of the method is the operational, transformation-based representation of those relationships. Given input grammars for convergence, they are transformed until they are structurally equal. The transformations are composed from primitive operators; properties of these operators and the composed chains provide quantitative and qualitative insight into the relationships between the grammars at hand. We describe a refined method for grammar convergence, and we use it in a major study, where we recover the relationships between all the grammars that occur in the different versions of the Java Language Specification (JLS). The relationships are represented as grammar transformation chains that capture all accidental or intended differences between the JLS grammars. This method is mechanized and driven by nominal and structural differences between pairs of grammars that are subject to asymmetric, binary convergence steps. We present the underlying operator suite for grammar transformation in detail, and we illustrate the suite with many examples of transformations on the JLS grammars. We also describe the extraction effort, which was needed to make the JLS grammars amenable to automated processing. We include substantial metadata about the convergence process for the JLS so that the effort becomes reproducible and transparent.
Additional file 1 of Multiple trauma in pregnant women: injury assessment, fetal radiation exposure and mortality. A multicentre observational study
Creators: name: Abback, Paer-Selim
name: Benchetrit, Alison
name: Delhaye, Nathalie
name: Daire, Jean-Luc
name: James, Arthur
name: Neuschwander, Arthur
name: Boutonnet, Mathieu
name: Cook, Fabrice
name: Vinour, Hélène
name: Hanouz, Jean-Luc
name: Cotte, Jean
name: Pastene, Bruno
name: Jouffroy, Viridiana
name: Gauss, Tobias
name: Group, Traumabase
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Science Policy

description: Supplementary Material 1
Theory of planet formation and comparison with observation: Formation of the planetary mass-radius relationship
Creators: name: Mordasini, C.
name: Alibert, Y.
name: Benz, W.
name: Klahr, H.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The planetary mass-radius diagram is an observational result of central importance to understand planet formation. We present an updated version of our planet formation model based on the core accretion paradigm which allows to calculate planetary radii and luminosities during the entire formation and evolution of the planets. We first study with it the formation of Jupiter, and compare with previous works. Then we conduct planetary population synthesis calculations to obtain a synthetic mass-radius diagram which we compare with the observed one. Except for bloated Hot Jupiters which can be explained only with additional mechanisms related to their proximity to the star, we find a good agreement of the general shape of the observed and the synthetic mass-radius diagram. This shape can be understood with basic concepts of the core accretion model.
description: Proceedings Haute Provence Observatory Colloquium: Detection and Dynamics of Transiting Exoplanets (23-27 August 2010). Edited by F. Bouchy, R. F. Diaz & C. Moutou. Extended version: 17 pages, 8 figures
An adaptable analysis workflow for characterization of platelet spreading and morphology
Creators: name: Pike, Jeremy A.
name: Simms, Victoria A.
name: Smith, Christopher W.
name: Morgan, Neil V.
name: Khan, Abdullah O.
name: Poulter, Natalie S.
name: Styles, Iain B.
name: Thomas, Steven G.
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: The assessment of platelet spreading through light microscopy, and the subsequent quantification of parameters such as surface area and circularity, is a key assay for many platelet biologists. Here we present an analysis workflow which robustly segments individual platelets to facilitate the analysis of large numbers of cells while minimizing user bias. Image segmentation is performed by interactive learning and touching platelets are separated with an efficient semi-automated protocol. We also use machine learning methods to robustly automate the classification of platelets into different subtypes. These adaptable and reproducible workflows are made freely available and are implemented using the open-source software KNIME and ilastik.
Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy
Creators: name: Thisted, Louise
name: Østergaard, Mette V.
name: Pedersen, Annemarie A.
name: Pedersen, Philip J.
name: Lindsay, Ross T.
name: Murray, Andrew J.
name: Fink, Lisbeth N.
name: Pedersen, Tanja X.
name: Secher, Thomas
name: Johansen, Thea T.
name: Thrane, Sebastian T.
name: Skarsfeldt, Torben
name: Jelsing, Jacob
name: Thomsen, Morten B.
name: Zois, Nora E.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2020
Subjects: Article
/692/163/2743/137/138
/692/163/2743/137
article

description: Abstract: Cardiovascular and renal complications are the predominant causes of morbidity and mortality amongst patients with diabetes. Development of novel treatments have been hampered by the lack of available animal models recapitulating the human disease. We hypothesized that experimental diabetes in rats combined with a cardiac or renal stressor, would mimic diabetic cardiomyopathy and nephropathy, respectively. Diabetes was surgically induced in male Sprague Dawley rats by 90% pancreatectomy (Px). Isoprenaline (Iso, 1 mg/kg, sc., 10 days) was administered 5 weeks after Px with the aim of inducing cardiomyopathy, and cardiac function and remodeling was assessed by echocardiography 10 weeks after surgery. Left ventricular (LV) fibrosis was quantified by Picro Sirius Red and gene expression analysis. Nephropathy was induced by Px combined with uninephrectomy (Px-UNx). Kidney function was assessed by measurement of glomerular filtration rate (GFR) and urine albumin excretion, and kidney injury was evaluated by histopathology and gene expression analysis. Px resulted in stable hyperglycemia, hypoinsulinemia, decreased C-peptide, and increased glycated hemoglobin (HbA1c) compared with sham-operated controls. Moreover, Px increased heart and LV weights and dimensions and caused a shift from α-myosin heavy chain (MHC) to β-MHC gene expression. Isoprenaline treatment, but not Px, decreased ejection fraction and induced LV fibrosis. There was no apparent interaction between Px and Iso treatment. The superimposition of Px and UNx increased GFR, indicating hyperfiltration. Compared with sham-operated controls, Px-UNx induced albuminuria and increased urine markers of kidney injury, including neutrophil gelatinase-associated lipocalin (NGAL) and podocalyxin, concomitant with upregulated renal gene expression of NGAL and kidney injury molecule 1 (KIM-1). Whereas Px and isoprenaline separately produced clinical endpoints related to diabetic cardiomyopathy, the combination of the two did not accentuate disease development. Conversely, Px in combination with UNx resulted in several clinical hallmarks of diabetic nephropathy indicative of early disease development.
Additional file 2 of Multiple trauma in pregnant women: injury assessment, fetal radiation exposure and mortality. A multicentre observational study
Creators: name: Abback, Paer-Selim
name: Benchetrit, Alison
name: Delhaye, Nathalie
name: Daire, Jean-Luc
name: James, Arthur
name: Neuschwander, Arthur
name: Boutonnet, Mathieu
name: Cook, Fabrice
name: Vinour, Hélène
name: Hanouz, Jean-Luc
name: Cotte, Jean
name: Pastene, Bruno
name: Jouffroy, Viridiana
name: Gauss, Tobias
name: Group, Traumabase
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Biotechnology
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Developmental Biology
subject: Science Policy

description: Supplementary Material 2
Variational principles for conformal geodesics
Creators: name: Dunajski, Maciej
name: Kryński, Wojciech
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Article
Conformal geodesics
Lagrangians
Hamiltonians
58E10
53C18

description: Abstract: Conformal geodesics are solutions to a system of third-order equations, which makes a Lagrangian formulation problematic. We show how enlarging the class of allowed variations leads to a variational formulation for this system with a third-order conformally invariant Lagrangian. We also discuss the conformally invariant system of fourth-order ODEs arising from this Lagrangian and show that some of its integral curves are spirals.
Stochastic population oscillations in spatial predator-prey models
Creators: name: Tauber, Uwe C.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Populations and Evolution (q-bio.PE)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Biological sciences
subject: FOS: Physical sciences

description: It is well-established that including spatial structure and stochastic noise in models for predator-prey interactions invalidates the classical deterministic Lotka-Volterra picture of neutral population cycles. In contrast, stochastic models yield long-lived, but ultimately decaying erratic population oscillations, which can be understood through a resonant amplification mechanism for density fluctuations. In Monte Carlo simulations of spatial stochastic predator-prey systems, one observes striking complex spatio-temporal structures. These spreading activity fronts induce persistent correlations between predators and prey. In the presence of local particle density restrictions (finite prey carrying capacity), there exists an extinction threshold for the predator population. The accompanying continuous non-equilibrium phase transition is governed by the directed-percolation universality class. We employ field-theoretic methods based on the Doi-Peliti representation of the master equation for stochastic particle interaction models to (i) map the ensuing action in the vicinity of the absorbing state phase transition to Reggeon field theory, and (ii) to quantitatively address fluctuation-induced renormalizations of the population oscillation frequency, damping, and diffusion coefficients in the species coexistence phase.
description: 14 pages, 6 figures, submitted to J. Phys C: Conf. Ser. (2011)
Fermi-LAT Study of Gamma-ray Emission in the Direction of Supernova Remnant W49B
Creators: name: LAT Collaboration
Publisher: name: arXiv
Year: 2010
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We present an analysis of the gamma-ray data obtained with the Large Area Telescope (LAT) onboard the Fermi Gamma-ray Space Telescope in the direction of SNR W49B (G43.3-0.2). A bright unresolved gamma-ray source detected at a significance of 38 sigma is found to coincide with SNR W49B. The energy spectrum in the 0.2-200 GeV range gradually steepens toward high energies. The luminosity is estimated to be 1.5x10^{36} (D/8 kpc)^2 erg s^-1 in this energy range. There is no indication that the gamma-ray emission comes from a pulsar. Assuming that the SNR shell is the site of gamma-ray production, the observed spectrum can be explained either by the decay of neutral pi mesons produced through the proton-proton collisions or by electron bremsstrahlung. The calculated energy density of relativistic particles responsible for the LAT flux is estimated to be remarkably large, U_{e,p}>10^4 eV cm^-3, for either gamma-ray production mechanism.
description: 9 pages, 10 figures
VLTI observations of the dust geometry around R Coronae Borealis stars
Creators: name: Bright, S. N.
name: Chesneau, O.
name: Clayton, G. C.
name: De Marco, O.
name: Leão, I. C.
name: Nordhaus, J.
name: Gallagher, J. S.
Publisher: name: arXiv
Year: 2011
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We are investigating the formation and evolution of dust around the hydrogen-deficient supergiants known as R Coronae Borealis (RCB) stars. We aim to determine the connection between the probable merger past of these stars and their current dust-production activities. We carried out high-angular resolution interferometric observations of three RCB stars, namely RY Sgr, V CrA, and V854 Cen with the mid-IR interferometer, MIDI on the VLTI, using two telescope pairs. The baselines ranged from 30 to 60 m, allowing us to probe the dusty environment at very small spatial scales (~ 50 mas or 400 stellar radii). The observations of the RCB star dust environments were interpreted using both geometrical models and one-dimensional radiative transfer codes. From our analysis we find that asymmetric circumstellar material is apparent in RY Sgr, may also exist in V CrA, and is possible for V854 Cen. Overall, we find that our observations are consistent with dust forming in clumps ejected randomly around the RCB star so that over time they create a spherically symmetric distribution of dust. However, we conclude that the determination of whether there is a preferred plane of dust ejection must wait until a time series of observations are obtained.
description: Accepted for publication in MNRAS; 14 pages, 10 figures, 6 tables
title: Music Therapy with Children and Parents: Toward an Ecological Attitude
Creators: name: Flower, Claire
Publisher: name: Goldsmiths, University of London
Year: 2019

description: Since 2000 there has been significant growth in music therapy with children and parents. Empirical studies have primarily investigated outcomes associated with parental participation. Less literature addresses the processes through which therapy is enacted. 

The practice-led study is situated in a Child Development Service within the UK state-funded healthcare system. Within the music therapy service, and more widely across the profession, parental attendance has increased in recent years, challenging conventional frames of practice and theory. This study investigates the enactment of music therapy with a child and parent in relation to everyday practice, organisational and professional structures. 

The research consists of two interlinked, phenomenologically-informed studies. A preliminary study explores a single case of child, parent, and therapist, investigating experiences of those within it and musical-social processes. It uses a hybrid methodology of interviews and video microanalysis. The second main study, investigates the broader meshwork of people, places, events, and expertise through which music therapy with a child and parent is enacted. It employs focus groups with parents, music therapists, and healthcare staff. Methods drawn respectively from Interpretative Phenomenological Analysis and Grounded Theory are used. 

The findings of the preliminary study suggest that music therapy with a child and parent appears through emergent, complex activity and interactivity between participants. It is characterised by a permeability of traditional music therapy boundaries. The main study further reveals the musicing of child and parent in everyday life and the various forms of expertise through which this appears. 

The thesis argues for a radical realignment of practice, away from a conventional dyadic perception of music therapy. It proposes an ecological attitude by which music therapy is understood as a meshwork of interweaving lines of musicing, expertise, and emergence, within and beyond the therapy room. Implications for practice, theory, and research are drawn from this realignment.
Enhancement of the critical temperature in cuprate superconductors by inhomogeneous doping
Creators: name: Goren, Lilach
name: Altman, Ehud
Publisher: name: arXiv
Year: 2011
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We use a renormalized mean field theory to investigate the superconducting properties of underdoped cuprates embedded with overdoped or metallic regions that carry excess dopants. The overdoped regions are considered, within two different models, first as stripes of mesoscopic size larger than the coherence length and then as point impurities. In the former case we compute the temperature dependent superfluid stiffness by solving Bogoliubov de Gennes equations within the slave boson mean field theory. We average over stripes of different orientations to obtain an isotropic result. To compute the superfluid stiffness in the model with point impurities we resort to a diagrammatic expansion in the impurity concentration (to first order) and their strength (up to second order). We find analytic expressions for the disorder averaged superfluid stiffness and the critical temperature. For both types of inhomogeneity we find increased superfluid stiffness, and for a wide range of doping enhancement of Tc relative to a homogeneously underdoped system. Remarkably, in the case of microscopic impurities we find that the maximal Tc can be significantly increased compared to Tc at optimal doping of a pure system.
description: 16 pages, 6 figures
Public acceptability of the UK Soft Drinks Industry Levy: repeat cross-sectional analysis of the International Food Policy Study (2017–2019)
Creators: name: Adams, Jean
name: Pell, David
name: Penney, Tarra L
name: Hammond, David
name: Vanderlee, Lana
name: White, Martin
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Public health
1506
1724
nutrition & dietetics
public health
health policy

description: Objectives: To determine whether public acceptability, in terms of both support for and perceived effectiveness of, the UK Soft Drinks Industry Levy (SDIL) changed between 4 months prior to, and 8 and 20 months after, implementation. Design: Repeat cross-sectional online survey. Setting: The UK. Participants: UK respondents to the International Food Policy Study aged 18–64 years who provided information on all variables of interest in November–December 2017 (4 months prior to SDIL implementation), 2018 (8 months after) or 2019 (20 months after; n=10 284). Outcome measures: Self-reported support for, and perceived effectiveness of, the SDIL. Results: The adjusted logistic regression model predicted that 70% (95% CI: 68% to 72%) of participants supported the SDIL in 2017, 68% (95% CI: 67% to 70%) in 2018 and 68% (95% CI: 66% to 70%) in 2019. There was no evidence of a difference in support in 2018 vs 2017 (OR: 0.93; 95% CI: 0.81 to 1.05); or in 2019 vs 2017 (OR: 0.90; 95% CI: 0.78 to 1.03). The adjusted logistic regression model predicted that 72% (95% CI: 70% to 74%) of participants perceived the SDIL to be effective in 2017, 67% (95% CI: 65% to 69%) in 2018 and 67% (95% CI: 64% to 69%) in 2019. There was evidence that perceived effectiveness decreased a small amount in 2018 vs 2017 (OR: 0.78; 95% CI: 0.69 to 0.88). The difference in 2019 vs 2017 was similar. Conclusions: We found high support for the SDIL among UK adults and this did not change between 4 months before implementation and 8 or 20 months after. While perceived effectiveness remained high, there was evidence that this decreased slightly after implementation in 2018, but no further in 2019. Greater understanding of influences on public acceptability of effective structural public health interventions is required.
title: Developing an OpenFOAM solver for coupled aero-hydrodynamic analysis of integrated structure with floating offshore wind turbine and aquaculture net cage
Creators: name: Cai, Yefeng
name: Zhao, Haisheng
name: Li, Xin
name: Shi, Wei
name: Xiao, Qing
Publisher: name: Strathprints - University of Strathclyde
Year: 2025

description: The integrated structure of floating offshore wind turbines (FOWTs) and aquaculture net cages has garnered significant attention in recent years. This study establishes, for the first time, a CFD analysis method for the integrated structure of FOWTs and aquaculture cages, and develops a specialized solver, HybridMarineFoam, for coupled analysis of the integrated structure. The solver currently includes aerodynamic, hydrodynamic, mooring, and aquaculture cage computation modules. The aquaculture cage module is based on the Darcy-Forchheimer model, incorporating the influence of the floating platform's motion into the Darcy-Forchheimer equation and accounting for the hydrodynamic impact of the cage on the floating platform, thus achieving coupled calculations between the fish cage and the floating platform. In this study, the force loading calculation for the moving aquaculture cage and the coupling simulation for the integrated structure have been very well validated. Subsequently, an integrated structure, combining an IEA 15 MW FOWT and an aquaculture cage, was proposed, and the HybridMarineFoam solver was used to analyze its aerodynamic, hydrodynamic, and flow field characteristics under different wind speeds, wave heights and water current speeds. The results reveal that the presence of the cage significantly impacts the system dynamics motion response and flow field characteristics of the floating wind turbine.
Protamine stimulates platelet aggregation in vitro with activation of the fibrinogen receptor and alpha-granule release, but impairs secondary activation via ADP and thrombin receptors
Creators: name: Törnudd, Mattias
name: Ramström, Sofia
name: Kvitting, John-Peder Escobar
name: Alfredsson, Joakim
name: Pihl, Richard
name: Berg, Sören
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Heparin and protamine are fundamental in the management of anticoagulation during cardiac surgery. Excess protamine has been associated with increased bleeding. Interaction between protamine and platelet function has been demonstrated but the mechanism remains unclear. We examined the effect of protamine on platelet function in vitro using impedance aggregometry, flow cytometry, and thrombin generation. Platelets were exposed to protamine at final concentrations of 0, 20, 40, and 80 µg/mL, alone or together with adenosine diphosphate (ADP) or thrombin PAR1 receptor-activating peptide (TRAP). We found that in the absence of other activators, protamine (80 µg/mL) increased the proportion of platelets with active fibrinogen receptor (binding of PAC-1) from 3.6% to 97.0% (p < .001) measured with flow cytometry. Impedance aggregometry also increased slightly after exposure to protamine alone. When activated with ADP or TRAP protamine at 80 µg/mL reduced aggregation, from 73.8 ± 29.4 U to 46.9 ± 21.1 U (p < .001) with ADP and from 126.4 ± 16.1 U to 94.9 ± 23.7 U (p < .01) with TRAP. P-selectin exposure (a marker of alpha-granule release) measured by median fluorescence intensity (MFI) increased dose dependently with protamine alone, from 0.76 ± 0.20 (0 µg/mL) to 10.2 ± 3.1 (80 µg/mL), p < .001. Protamine 80 µg/mL by itself resulted in higher MFI (10.16 ± 3.09) than activation with ADP (2.2 ± 0.7, p < .001) or TRAP (5.7 ± 2.6, p < .01) without protamine. When protamine was combined with ADP or TRAP, there was a concentration-dependent increase in the alpha-granule release. In conclusion, protamine interacts with platelets in vitro having both a direct activating effect and impairment of secondary activation of aggregation by other agonists.
Automated Reasoning and Presentation Support for Formalizing Mathematics in Mizar
Creators: name: Urban, Josef
name: Sutcliffe, Geoff
Publisher: name: arXiv
Year: 2010
Subjects: subject: Artificial Intelligence (cs.AI)
subject: FOS: Computer and information sciences

description: This paper presents a combination of several automated reasoning and proof presentation tools with the Mizar system for formalization of mathematics. The combination forms an online service called MizAR, similar to the SystemOnTPTP service for first-order automated reasoning. The main differences to SystemOnTPTP are the use of the Mizar language that is oriented towards human mathematicians (rather than the pure first-order logic used in SystemOnTPTP), and setting the service in the context of the large Mizar Mathematical Library of previous theorems,definitions, and proofs (rather than the isolated problems that are solved in SystemOnTPTP). These differences poses new challenges and new opportunities for automated reasoning and for proof presentation tools. This paper describes the overall structure of MizAR, and presents the automated reasoning systems and proof presentation tools that are combined to make MizAR a useful mathematical service.
description: To appear in 10th International Conference on. Artificial Intelligence and Symbolic Computation AISC 2010
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titleType: Subtitle
title: Node connections of the steel frame with mounted FCW (frame cladding wall) panels in multilevel buildings
Creators: name: Ð ÑÐ·Ð°Ð½Ð¾Ð²Ð°, ÐÑÐ´Ð¼Ð¸Ð»Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2019
Subjects: Ð¡ÑÑÐ¾Ð¸ÑÐµÐ»ÑÐ½ÑÐµ ÐºÐ¾Ð½ÑÑÑÑÐºÑÐ¸Ð¸ ÑÐ¾Ð½ÐºÐ¾ÑÑÐµÐ½Ð½ÑÐµ
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description: Ð Ð´Ð°Ð½Ð½Ð¾Ð¹ Ð¼Ð°Ð³Ð¸ÑÑÐµÑÑÐºÐ¾Ð¹ Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ð¸ ÑÐ°ÑÑÐ¼Ð°ÑÑÐ¸Ð²Ð°ÐµÑÑÑ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ðµ Ð½Ð°Ð²ÐµÑÐ½ÑÑ ÐºÐ°ÑÐºÐ°ÑÐ½Ð¾-Ð¾Ð±ÑÐ¸Ð²Ð½ÑÑ ÑÑÐµÐ½Ð¾Ð²ÑÑ Ð¿Ð°Ð½ÐµÐ»ÐµÐ¹ Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ðµ Ð»ÑÐ³ÐºÐ¸Ñ ÑÑÐ°Ð»ÑÐ½ÑÑ ÑÐ¾Ð½ÐºÐ¾ÑÑÐµÐ½Ð½ÑÑ ÐºÐ¾Ð½ÑÑÑÑÐºÑÐ¸Ð¹ Ð² Ð¾Ð³ÑÐ°Ð¶Ð´Ð°ÑÑÐ¸Ñ ÐºÐ¾Ð½ÑÑÑÑÐºÑÐ¸ÑÑ Ð¼Ð½Ð¾Ð³Ð¾ÑÑÐ°Ð¶Ð½Ð¾Ð³Ð¾ Ð·Ð´Ð°Ð½Ð¸Ñ ÑÐ¾ ÑÑÐ°Ð»ÑÐ½ÑÐ¼ Ð½ÐµÑÑÑÐ¸Ð¼ ÐºÐ°ÑÐºÐ°ÑÐ°Ð¼. Ð Ð°ÑÑÐ¼Ð¾ÑÑÐµÐ½Ð¾ ÑÐ¾Ð²ÑÐµÐ¼ÐµÐ½Ð½Ð¾Ðµ ÑÐ¾ÑÑÐ¾ÑÐ½Ð¸Ðµ Ð²Ð¾Ð¿ÑÐ¾ÑÐ°, Ð¿ÑÐ¾Ð°Ð½Ð°Ð»Ð¸Ð·Ð¸ÑÐ¾Ð²Ð°Ð½ ÑÐ¾ÑÑÐ¸Ð¹ÑÐºÐ¸Ð¹ Ð¸ Ð·Ð°ÑÑÐ±ÐµÐ¶Ð½ÑÐ¹ Ð¾Ð¿ÑÑ. ÐÑÐ¾Ð¸Ð·Ð²ÐµÐ´ÐµÐ½ ÑÐµÐ¿Ð»Ð¾ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ°ÑÑÐµÑ Ð¿Ð°Ð½ÐµÐ»Ð¸, ÐºÐ¾ÑÐ¾ÑÑÐ¹ Ð¿Ð¾ÐºÐ°Ð·ÑÐ²Ð°ÐµÑ ÑÐ½ÐµÑÐ³Ð¾ÑÑÑÐµÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ ÐµÐµ Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ. Ð Ð°Ð·ÑÐ°Ð±Ð¾ÑÐ°Ð½Ñ ÑÐµÐºÐ¾Ð¼ÐµÐ½Ð´Ð°ÑÐ¸Ð¸ Ð¿Ð¾ Ð¿Ð¾Ð´Ð±Ð¾ÑÑ Ð¿Ð°Ð½ÐµÐ»Ð¸ Ð¸ ÐµÐµ Ð¼Ð¾Ð½ÑÐ°Ð¶Ð° Ñ ÑÐºÐ°Ð·Ð°Ð½Ð¸Ðµ ÑÑÐµÐ±Ð¾Ð²Ð°Ð½Ð¸Ð¹ Ð¿Ð¾ Ð±ÐµÐ·Ð¾Ð¿Ð°ÑÐ½Ð¾ÑÑÐ¸ Ð½Ð° ÑÑÑÐ¾Ð¸ÑÐµÐ»ÑÐ½Ð¾Ð¹ Ð¿Ð»Ð¾ÑÐ°Ð´ÐºÐµ. ÐÑÐ¾Ð²ÐµÐ´ÐµÐ½Ð¾ ÐºÐ¾Ð½ÐµÑÐ½Ð¾-ÑÐ»ÐµÐ¼ÐµÐ½ÑÐ½Ð¾Ðµ Ð¼Ð¾Ð´ÐµÐ»Ð¸ÑÐ¾Ð²Ð°Ð½Ð¸Ðµ 3 Ð²Ð¸Ð´Ð¾Ð² Ð¿Ð°Ð½ÐµÐ»ÐµÐ¹ Ñ ÑÐ°Ð·Ð»Ð¸ÑÐ½ÑÐ¼ ÑÐ°Ð³Ð¾Ð¼ Ð²ÐµÑÑÐ¸ÐºÐ°Ð»ÑÐ½ÑÑ ÑÑÐ¾ÐµÐº, Ð½Ð° Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð¸Ð¸ ÑÐµÐ³Ð¾ Ð´Ð°Ð½Ñ ÑÐµÐºÐ¾Ð¼ÐµÐ½Ð´Ð°ÑÐ¸Ð¸ Ð½Ð° Ð¿ÑÐ¸Ð¼ÐµÐ½ÐµÐ½Ð¸Ñ ÑÐ·Ð»Ð¾Ð²Ð¾Ð³Ð¾ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ñ.
description: This master's thesis discusses the use of hinged frame-sheath wall panels based on light steel thin-walled structures in enclosing structures of a multi-storey building with steel supporting frames. Considered the current state of the issue, analyzed the Russian and foreign experience. Thermal calculation of the panel was made, which shows the energy efficiency of its application. Developed recommendations for the selection of the panel and its installation with an indication of safety requirements at the construction site. Finite element modeling of 3 types of panels with different pitch of vertical columns was carried out, on the basis of which recommendations were made for the use of a nodal connection.
Genomic risk prediction of coronary artery disease in women with breast cancer: a prospective cohort study
Creators: name: Liou, Lathan
name: Kaptoge, Stephen
name: Dennis, Joe
name: Shah, Mitul
name: Tyrer, Jonathan
name: Inouye, Michael
name: Easton, Douglas F.
name: Pharoah, Paul D. P.
Publisher: name: Apollo - University of Cambridge Repository
Year: 2021
Subjects: Research Article
Polygenic risk score
Breast cancer
Coronary artery disease
Coronary heart disease
Cardiovascular disease
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description: Abstract: Background: Advancements in cancer therapeutics have resulted in increases in cancer-related survival; however, there is a growing clinical dilemma. The current balancing of survival benefits and future cardiotoxic harms of oncotherapies has resulted in an increased burden of cardiovascular disease in breast cancer survivors. Risk stratification may help address this clinical dilemma. This study is the first to assess the association between a coronary artery disease-specific polygenic risk score and incident coronary artery events in female breast cancer survivors. Methods: We utilized the Studies in Epidemiology and Research in Cancer Heredity prospective cohort involving 12,413 women with breast cancer with genotype information and without a baseline history of cardiovascular disease. Cause-specific hazard ratios for association of the polygenic risk score and incident coronary artery disease (CAD) were obtained using left-truncated Cox regression adjusting for age, genotype array, conventional risk factors such as smoking and body mass index, as well as other sociodemographic, lifestyle, and medical variables. Results: Over a median follow-up of 10.3 years (IQR: 16.8) years, 750 incident fatal or non-fatal coronary artery events were recorded. A 1 standard deviation higher polygenic risk score was associated with an adjusted hazard ratio of 1.33 (95% CI 1.20, 1.47) for incident CAD. Conclusions: This study provides evidence that a coronary artery disease-specific polygenic risk score can risk-stratify breast cancer survivors independently of other established cardiovascular risk factors.
Operator, number please : mediating access to shared resources for efficiency and isolation
Creators: name: Nanavati, Mihir Sudarshan
Publisher: name: University of British Columbia
Year: 2019

description: The performance density of modern hardware has forced the sharing of hardware resources across applications for better utilization and efficiency. Shared infrastructure, however, weakens isolation and risks interference, which can result in degraded performance and security breaches. This thesis explores the tension between isolation and sharing with three prototype systems: Xoar, Plastic, and Decibel. All three of these systems demonstrate the value of software mediation in providing isolation on shared hardware without sacrificing either hardware resource utilization or the performance of the underlying devices. Xoar, Plastic, and Decibel provide isolation for different hardware resources: Xoar strengthens isolation between virtual machines, thereby allowing underutilized processors to be shared; Plastic transparently mitigates poor cache utilization and the performance artifacts caused by insufficient cache line isolation across cores; and Decibel provides isolation in shared non-volatile storage and guarantees throughput, even in the face of competing workloads.