cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
An expanded evaluation of protein function prediction methods shows an improvement in accuracy
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2016
Subjects: Protein function prediction
Disease gene prioritization

description: © 2016 The Author(s). Background: A major bottleneck in our understanding of the molecular underpinnings of life is the assignment of function to proteins. While molecular experiments provide the most reliable annotation of proteins, their relatively low throughput and restricted purview have led to an increasing role for computational function prediction. However, assessing methods for protein function prediction and tracking progress in the field remain challenging. Results: We conducted the second critical assessment of functional annotation (CAFA), a timed challenge to assess computational methods that automatically assign protein function. We evaluated 126 methods from 56 research groups for their ability to predict biological functions using Gene Ontology and gene-disease associations using Human Phenotype Ontology on a set of 3681 proteins from 18 species. CAFA2 featured expanded analysis compared with CAFA1, with regards to data set size, variety, and assessment metrics. To review progress in the field, the analysis compared the best methods from CAFA1 to those of CAFA2. Conclusions: The top-performing methods in CAFA2 outperformed those from CAFA1. This increased accuracy can be attributed to a combination of the growing number of experimental annotations and improved methods for function prediction. The assessment also revealed that the definition of top-performing algorithms is ontology specific, that different performance metrics can be used to probe the nature of accurate predictions, and the relative diversity of predictions in the biological process and human phenotype ontologies. While there was methodological improvement between CAFA1 and CAFA2, the interpretation of results and usefulness of individual methods remain context-dependent.
LIPS: A light intensity-based positioning system for indoor environments
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2016
Subjects: Design
Algorithms
Performance
Light intensity
indoor positioning
LED sensor
smartphones

description: © 2016 ACM. This article presents a Light Intensity-based Positioning System (LIPS) for indoor environments. The system uses off-the-shelf light-emitting diode lamps as signal sources and light sensors as signal receivers. The design is inspired by the observation that a light sensor has deterministic sensitivity to both the distance and incident angle of a light signal, an under-utilized feature of photodiodes now widely found on mobile devices. We develop a stable and accurate light intensity model to capture the phenomenon, based on which a new positioning principle, Multi-Face Light Positioning, is established that uses three collocated sensors to uniquely determine the receiver's position, assuming merely a single source of light. We have implemented a prototype on both dedicated embedded systems and smartphones. Experimental results show average positioning accuracy within 0.4m across different environments, with high stability against interferences from obstacles, ambient lights, temperature variation, and so on.
Henry Hopkins and George Clarke: Two Tasmanian nonconformists
Creators: name: Alexander, Alison
Publisher: name: University Of Tasmania
Year: 2023

description: Henry Hopkins and George Clarke were two Congregationalists who lived in Tasmania between 1822 and 1913. Hopkins and his wife, both of lower middle-class origins, emigrated to the colony and quickly built up wealth, by importing and retailing ironmongery and by largely establishing the wool trade in Van Diemen's Land. Hopkins used his wealth to establish the Congregational church, and to attempt to build up a society where honest labourers could, by hard work, achieve independence. To this end he was one of a group who established banks, insurance companies, churches, schools and new industries, and supported many charities. When Victoria was settled, he duplicated his Tasmanian activities there. Hopkins' career is typical of many nonconformist merchants, and is a negation of the prevalent view that Van Diemen's Land was inhabited by bad convicts and worse free settlers. Clarke, Hopkins' son-in-law, was a Congregationalist minister, highly regarded by the community as a whole, and with a most influential congregation. He eschewed money-making and politics, and through sermons, lectures and pamphlets encouraged Tasmanians to be tolerant and reasonable. Though conciliatory, he occasionally made a public stand, for example, against Chiniquy's antiCatholic behaviour, and, earlier in New Zealand, against white injustice to the Maoris. Like Hopkins, Clarke was interested in education, though more at the tertiary level. He was instrumental in establishing the University of Tasmania, was its first Vice-Chancellor (1890--1898), then Chancellor (1898-1907). It was due to his wise leadership that the university survived many crises in these years. Hopkins and Clarke typify several trends in Tasmanian history: from rather Dickensian early days to a more sophisticated outlook, from a strongly evangelical creed to a more reasoned one, from a society largely concerned with economic survival to a secure, middle-class environ- ment. They also typify a class whose contribution to Tasmanian development has been largely ignored.
Magnetic properties of a spin-3 Chromium condensate
Creators: name: He, Liang
name: Yi, Su
Publisher: name: arXiv
Year: 2009
Subjects: subject: Other Condensed Matter (cond-mat.other)
subject: FOS: Physical sciences

description: We study the ground state properties of a spin-3 Cr condensate subject to an external magnetic field by numerically solving the Gross-Piteavskii equations. We show that the widely adopted single-mode approximation is invalid under a finite magnetic field. In particular, a phase separation like behavior may be induced by the magnetic field. We also point out the possible origin of the phase separation phenomenon.
description: 6 pages, 5 figures
Methyl 5-chloro-2-hydr-oxy-3-(4-methoxyphenyl)-4,6-dimethylbenzoate
Creators: name: Adeel, M.
name: Ali, I.
name: Langer, P.
name: Villinger, A.
Publisher: name: Chester : International Union of Crystallography
Year: 2009
Subjects: subject: Crystal structure
subject: Chemistry
subject: Crystallography
subject: 540

description: In the title compound, C17H17ClO4, the dihedral angle between the mean planes of the two benzene rings is 65.92 (5)°. The methyl ester group lies within the ring plane [deviations of O atoms from the plane = -0.051 (2) and 0.151 (2) Å] due to an intra-molecular O - H⋯O hydrogen bond. In the crystal, molecules are held together by rather weak non-classical inter-molecular C - H⋯O hydrogen bonds, resulting in dimeric units about inversion centers, forming eight- and ten-membered ring systems as R22(8) and R2 2(10) motifs. © Adeel et al. 2009.
Tracers of stellar mass-loss. I. Optical and near-IR colours and surface brightness fluctuations
Creators: name: Gonzalez-Lopezlira, Rosa A.
name: Bruzual-A., Gustavo
name: Charlot, Stephane
name: Ballesteros-Paredes, Javier
name: Loinard, Laurent
Publisher: name: arXiv
Year: 2009
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We present optical and IR integrated colours and SBF magnitudes, computed from stellar population synthesis models that include emission from the dusty envelopes surrounding TP-AGB stars undergoing mass-loss. We explore the effects of varying the mass-loss rate by one order of magnitude around the fiducial value, modifying accordingly both the stellar parameters and the output spectra of the TP-AGB stars plus their dusty envelopes. The models are single burst, and range in age from a few Myr to 14 Gyr, and in metallicity between $Z$ = 0.0001 and $Z$ = 0.07; they combine new calculations for the evolution of stars in the TP-AGB phase, with star plus envelope SEDs produced with the radiative transfer code DUSTY. We compare these models to optical and near-IR data of single AGB stars and Magellanic star clusters. This comparison validates the current understanding of the role of mass-loss in determining stellar parameters and spectra in the TP-AGB. However, neither broad-band colours nor SBF measurements in the optical or the near-IR can discern global changes in the mass-loss rate of a stellar population. We predict that mid-IR SBF measurements can pick out such changes, and actually resolve whether a relation between metallicity and mass-loss exists.
description: 31 pages, 17 figures, accepted for publication in MNRAS
Probing the reconstructed Fermi surface of antiferromagnetic BaFe2As2 in one domain
Creators: name: Watson, M.D.
name: Dudin, P.
name: Rhodes, L.C.
name: Evtushinsky, D.V.
name: Iwasawa, H.
name: Aswartham, S.
name: Wurmehl, S.
name: Büchner, B.
name: Hoesch, M.
name: Kim, T.K.
Publisher: name: London : Nature Publishing Group
Year: 2019
Subjects: subject: superconductivity
subject: nematic instabilities
subject: magnetic instabilities
subject: 620

description: A fundamental part of the puzzle of unconventional superconductivity in the Fe-based superconductors is the understanding of the magnetic and nematic instabilities of the parent compounds. The issues of which of these can be considered the leading instability, and whether weak- or strong-coupling approaches are applicable, are both critical and contentious. Here, we revisit the electronic structure of BaFe2As2 using angle-resolved photoemission spectroscopy (ARPES). Our high-resolution measurements of samples “detwinned” by the application of a mechanical strain reveal a highly anisotropic 3D Fermi surface in the low-temperature antiferromagnetic phase. By comparison of the observed dispersions with ab initio calculations, we argue that overall it is magnetism, rather than orbital/nematic ordering, which is the dominant effect, reconstructing the electronic structure across the Fe 3d bandwidth. Finally, using a state-of-the-art nano-ARPES system, we reveal how the observed electronic dispersions vary in real space as the beam spot crosses domain boundaries in an unstrained sample, enabling the measurement of ARPES data from within single antiferromagnetic domains, and showing consistence with the effective mono-domain samples obtained by detwinning.
Association between high school students' cigarette smoking, asthma and related beliefs: A population-based study
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2016
Subjects: Adolescents
Asthma
Smoking
Smoking-related beliefs

description: © 2016 The Author(s). Background: Smoking has a detrimental effect on the symptoms and severity of asthma, a common chronic disease among adolescents. The purpose of this study was to examine the association between asthma and smoking among high school students and assess provider-patient communication with asthmatic adolescents regarding smoking and adolescents' beliefs about the harms of smoking. Methods: In fall 2014, data from high school students, ages 14-18 years, completing the 2009-2010 Virginia Youth Tobacco Survey (N = 1796) were used in descriptive analyses and multivariable logistic regression models adjusting for model-specific confounders as appropriate. Results: Overall, an estimated 19 % of high school students in Virginia smoked and 16 % had asthma. Odds of smoking did not differ by asthma status; however, asthmatics had 1.5 times higher odds of being asked if they smoke (95 % CI 1.06-2.13) and being advised not to smoke by a health professional (95 % CI 1.10-2.14) compared to non-asthmatics. Asthmatics who believed second-hand smoke or smoking 1-5 cigarettes/day was not harmful had respectively 4.2 and 2.8 times higher odds of smoking than those who thought each was harmful. Further, asthmatics who thought smoking 1-2 years is safe had 3.4 times higher odds of smoking than those who did not (95 % CI 1.57-10.1). Conclusions: While asthmatic adolescents are just as likely to smoke as non-asthmatics, less healthy beliefs about the risks of smoking increase the odds of smoking among asthmatics. Thus, targeted asthma-specific smoking prevention and education to change attitudes and beliefs could be an effective tool for adolescents.
Singlet-triplet transition in a few-electron lateral InGaAs-InAlAs quantum dot
Creators: name: Deon, F.
name: Pellegrini, V.
name: Carillo, F.
name: Giazotto, F.
name: Sorba, L.
name: Biasiol, G.
name: Beltram, F.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The magnetic-field evolution of Coulomb blockade peaks in lateral InGaAs/InAlAs quantum dots in the few-electron regime is reported. Quantum dots are defined by gates evaporated onto a 60 nm-thick hydrogen silsesquioxane insulating film. A gyromagnetic factor of 4.4 is measured via zero-bias spin spectroscopy and a transition from singlet to triplet spin configuration is found at an in-plane magnetic field B = 0.7 T. This observation opens the way to the manipulation of singlet and triplet states at moderate fields and its relevance for quantum information applications will be discussed.
description: 4 pages, 3 figures
P-[N-(Diphenyl-phospho-rothio-yl)iso-propyl-amino]-N-isopropyl-P-phenyl- thio-phosphinic amide
Creators: name: Peulecke, N.
name: Aluri, B.R.
name: Wöhl, A.
name: Spannenberg, A.
name: Al-Hazmi, M.H.
Publisher: name: Chester : International Union of Crystallography
Year: 2009
Subjects: subject: Crystal structure
subject: Chemistry
subject: Crystallography
subject: 540

description: The title compound, C24H30N2P2S2, was obtained by the reaction of Ph2PN(iPr)P(Ph)N(iPr)H with elemental sulfur in tetra-hydro-furan. In the solid state, intra-molecular N - H⋯S hydrogen bonding influences the mol-ecular conformation; a P - N - P - N torsion angle of 2.28 (9)° is observed. The two phenyl rings attached to one P atom form a dihedral angle of 74.02 (4)°.
Coastal eutrophication a study of Orielton Lagoon
Creators: name: Brett, MA
Publisher: name: University Of Tasmania
Year: 2023

description: Orielton Lagoon, an enclosed estuary, was created in 1953 following the extension of a road causeway between Midway Point and Sorell. Over the past 30 years, decomposition of excessive macrophytic growth has been blamed, for the periodic occurrence of unpleasant, nauseating odours. The growth of macrophytes appears to be associated with rainfall patterns, temperature and nutrient levels in the lagoon. A biological survey of the lagoon indicated a highly eutrophic, hypersaline water body, rich in phytoplankton. Diatoms dominated the phytoplankton and there was a suppressed zooplankton population throughout the year. Average monthly chlorophyll levels varied between 10 and 43 J.Lg/L. The prime source of nutrients measured in 1991 was a sewage treatment plant at Midway Point which has discharged primary treated sewage into the lagoon since 1969. Nitrate levels were similar to those in the adjacent Pittwater area but phosphate levels in the lagoon were approximately double those in Pittwater. Computer modelling of water movement through the lagoon was used to estimate water exchange within the system. This highlighted the very limited water exchange with the existing restricted outlet and demonstrated the significant additional water movement that could be achieved by minor modification. The study has predicted changes in water quality that would result from both increased water flow and removal of nutrient input. To achieve a water quality similar to that in the neighbouring Pittwater area, with a chlorophyll level between 1 and 5 J.Lg/L, both the removal of the nutrient source and increased flushing of the system must be undertaken. The importance of the area as an internationally recognised wetland, important for migratory wading birds, is a prime consideration in any management plans to improve the water quality in the lagoon. The presence of a profitable aquacultural industry in the adjacent Pittwater area is also important in formulating future management practices.
Emergent Lorentz symmetry with vanishing velocity in a critical two-subband quantum wire
Creators: name: Sitte, M.
name: Rosch, A.
name: Meyer, J. S.
name: Matveev, K. A.
name: Garst, M.
Publisher: name: arXiv
Year: 2008
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We consider a quantum wire with two subbands of spin-polarized electrons in the presence of strong interactions. We focus on the quantum phase transition when the second subband starts to get filled as a function of gate voltage. Performing a one-loop renormalization group (RG) analysis of the effective Hamiltonian, we identify the critical fixed-point theory as a conformal field theory having an enhanced SU(2) symmetry and central charge 3/2. While the fixed point is Lorentz invariant, the effective 'speed of light' nevertheless vanishes at low energies due to marginally irrelevant operators leading to a diverging critical specific heat coefficient.
description: 4 pages, 3 figures, minor changes, published version
Oligothiophene-Based Phosphonates for Surface Modification of Ultraflat Transparent Conductive Oxides
Creators: name: Timpel, Melanie
name: Nardi, Marco V.
name: Wegner, Berthold
name: Ligorio, Giovanni
name: Pasquali, Luca
name: Hildebrandt, Jana
name: Pätzel, Michael
name: Hecht, Stefan
name: Ohta, Hiromichi
name: Koch, Norbert
Publisher: name: Weinheim : Wiley-VCH
Year: 2020
Subjects: subject: Indium-tin oxide
subject: phosphonic acid
subject: photoelectron spectroscopy
subject: self-assembled monolayer
subject: zinc oxide
subject: 540
subject: 600

description: The self-assembly of electroactive organic molecules on transparent conductive oxides is a versatile strategy to engineer the interfacial energy-level alignment and to enhance charge carrier injection in optoelectronic devices. Via chemical grafting of an aromatic oligothiophene molecule by changing the position of the phosphonic acid anchoring group with respect to the organic moiety (terminal and internal), the direction of the main molecular dipole is changed, i.e., from parallel to perpendicular to the substrate, to study the molecular arrangement and electronic properties at the organic–inorganic interface. It is found that the observed work function increase cannot solely be predicted based on the calculated molecular dipole moment of the oligothiophene-based phosphonates. In addition, charge transfer from the substrate to the molecule has to be taken into account. Molecular assembly and induced electronic changes are analogous for both indium-tin oxide (ITO) and zinc oxide (ZnO), demonstrating the generality of the approach and highlighting the direct correlation between molecular coverage and electronic effects. © 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Pulse propagation in tapered granular chains: An analytic study
Creators: name: Harbola, Upendra
name: Rosas, Alexandre
name: Esposito, Massimiliano
name: Lindenberg, Katja
Publisher: name: arXiv
Year: 2009
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: We study pulse propagation in one-dimensional tapered chains of spherical granules. Analytic results for the pulse velocity and other pulse features are obtained using a binary collision approximation. Comparisons with numerical results show that the binary collision approximation provides quantitatively accurate analytic results for these chains.
Large-Scale Discovery of Disease-Disease and Disease-Gene Associations
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2016
Subjects: Algorithms
Databases, Factual
Electronic Health Records
Genetic Diseases, Inborn
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Phenotype

description: © 2016 The Author(s). Data-driven phenotype analyses on Electronic Health Record (EHR) data have recently drawn benefits across many areas of clinical practice, uncovering new links in the medical sciences that can potentially affect the well-being of millions of patients. In this paper, EHR data is used to discover novel relationships between diseases by studying their comorbidities (co-occurrences in patients). A novel embedding model is designed to extract knowledge from disease comorbidities by learning from a large-scale EHR database comprising more than 35 million inpatient cases spanning nearly a decade, revealing significant improvements on disease phenotyping over current computational approaches. In addition, the use of the proposed methodology is extended to discover novel disease-gene associations by including valuable domain knowledge from genome-wide association studies. To evaluate our approach, its effectiveness is compared against a held-out set where, again, it revealed very compelling results. For selected diseases, we further identify candidate gene lists for which disease-gene associations were not studied previously. Thus, our approach provides biomedical researchers with new tools to filter genes of interest, thus, reducing costly lab studies.
Zirconium-Catalyzed Atom-Economical Synthesis of 1,1-Diborylalkanes from Terminal and Internal Alkenes
Creators: name: Wang, Xianjin
name: Cui, Xin
name: Li, Sida
name: Wang, Yue
name: Xia, Chungu
name: Jiao, Haijun
name: Wu, Lipeng
Publisher: name: Weinheim : Wiley-VCH
Year: 2020
Subjects: subject: alkenes
subject: borane
subject: boration
subject: homogeneous catalysis
subject: zirconium
subject: 540

description: A general and atom-economical synthesis of 1,1-diborylalkanes from alkenes and a borane without the need for an additional H2 acceptor is reported for the first time. The key to our success is the use of an earth-abundant zirconium-based catalyst, which allows a balance of self-contradictory reactivities (dehydrogenative boration and hydroboration) to be achieved. Our method avoids using an excess amount of another alkene as an H2 acceptor, which was required in other reported systems. Furthermore, substrates such as simple long-chain aliphatic alkenes that did not react before also underwent 1,1-diboration in our system. Significantly, the unprecedented 1,1-diboration of internal alkenes enabled the preparation of 1,1-diborylalkanes. © 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.
Electrophoretic mobility of a water-in-oil droplet separately affected by the net charge and surface charge density
Creators: name: Uematsu, Yuki
name: Ohshima, Hiroyuki
Publisher: name: arXiv
Year: 2023
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Chemical Physics (physics.chem-ph)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: Water-in-oil emulsions and droplets exhibit completely different physico-chemical properties compared to oil-in-water emulsions and droplets. Thus, directly applying a standard theoretical model to water-in-oil systems cannot describe these anomalous properties. Here, the electrophoretic mobility of a water-in-oil droplet is analytically investigated using Debye-Hückel linearization and neglecting Marangoni effect. The resulting electrophoretic mobility is shown to be separately dependent on the net charge of the droplet and the surface charge density at the droplet interface. Furthermore, when the net charge is negligible, electrophoretic mobility is proportional to the surface charge density with a negative coefficient. This indicates that the internal electric double layer inversely contributes the electrophoresis. This theory is applied to experimental data of water-in-oil emulsions and droplets in the literature, and qualitative and quantitative verification of the theory is discussed.
description: 11 pages, accepted version
Tourism in national parks: Managing a paradoxical mandate
Creators: name: Sutton, R
Publisher: name: University Of Tasmania
Year: 2023

description: This thesis deals with reconciling environmental protection and tourism in national parks. It asks, \What tourism is appropriate in national parks?\" The objective is to develop an assessment framework to answer this question. There is widespread contemporary discussion about the perceived economic benefits of tourism. Some argue that national parks should provide economic returns and job opportunities to the community. Consequently tourism particularly ecotourism is seen as a promising economic use of national parks. At the same time many people believe that national parks are important for environmental protection and preservation. The history of national parks the assumptions and values held about them and the legislation establishing them are examined to determine the roles and values of national parks today. The phenomenon of tourism is examined along with management responses to dealing with it in national parks. A confusion of purpose and the lack of a clear tourism assessment process are identified. The need for a framework to assess appropriate tourism in national parks is established and a new legislative policy and implementation framework is proposed. The framework sets out a clearly defined process identifying the key components necessary for its application. It requires an explicit legislative definition of national parks a statement of purpose in the formal gazettal of each park the setting of goals for the future character of each park the setting of goals and objectives for tourism in national parks and development of strategies for achieving the tourism goals and objectives. The key strategy is the development of criteria for assessing tourism proposals for national parks. To elaborate and test the framework the substance of some of the key components of it is proposed. The framework is further tested in a case study by applying it to Maria Island National Park. The case study proposes a statement of purpose and future character goals for the park. Tourism values and tourism opportunities for the park are identified. Limitations of the proposed framework are discussed and suggestions for further development are made."
Competing responses and resistance to extinction
Creators: name: Bradely, Harry Willard
Publisher: name: University of British Columbia
Year: 2011

description: At birth, male and female rats were randomly assigned to either a handled or nonhandled condition. The handled Ss were given tactual stimulation for a five minute period from days five to twenty-five. During the preweaning period Ss in the nonhandled condition were given the least possible amount of experimenter handling. When Ss were between 80 to 100 days old both handled and nonhandled Ss were randomly assigned to one of four acquisition conditions and were trained and tested in a straight alley runway. These conditions were; continuous reinforcement in a large goalbox, continuous reinforcement in a small goalbox, partial reinforcement in a large goalbox, and partial reinforcement in a small box. Each S was then given 60 acquisition trials at the rate of 5 trials per day. Following completion of the acquisition trials all Ss received 50 nonreward trials which were also given in blocks of 5 trials per day. On both acquisition and extinction trials, time measures were taken for startbox and runway performance. For the purpose of analysis all time measures were converted into speed scores. The results showed that all experimental treatments, (i.e. handling, reward schedule and goalbox size), had a significant effect on the rate of experimental extinction. Infantile handling, a partial reinforcement schedule, and a large goalbox were all conducive to decreasing the rate of extinction of a running response.
Homology Groups of Symmetric Quandles and Cocycle Invariants of Links and Surface-links
Creators: name: Kamada, Seiichi
name: Oshiro, Kanako
Publisher: name: arXiv
Year: 2009
Subjects: subject: Geometric Topology (math.GT)
subject: FOS: Mathematics
subject: 57M25; 57Q45

description: We introduce the notion of a quandle with a good involution and its homology groups. Carter et al. defined quandle cocycle invariants for oriented links and oriented surface-links. By use of good involutions, quandle cocyle invariants can be defined for links and surface-links which are not necessarily oriented or orientable. The invariants can be used in order to estimate the minimal triple point numbers of non-orientable surface-links.
Intensive treatment with ultrasound visual feedback for speech sound errors in childhood apraxia
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2016
Subjects: childhood apraxia of speech
intensive treatment program
speech therapy
ultrasound
visual feedback

description: © 2016 Preston, Leece and Maas. Ultrasound imaging is an adjunct to traditional speech therapy that has shown to be beneficial in the remediation of speech sound errors. Ultrasound biofeedback can be utilized during therapy to provide clients with additional knowledge about their tongue shapes when attempting to produce sounds that are erroneous. The additional feedback may assist children with childhood apraxia of speech (CAS) in stabilizing motor patterns, thereby facilitating more consistent and accurate productions of sounds and syllables. However, due to its specialized nature, ultrasound visual feedback is a technology that is not widely available to clients. Short-term intensive treatment programs are one option that can be utilized to expand access to ultrasound biofeedback. Schema-based motor learning theory suggests that short-term intensive treatment programs (massed practice) may assist children in acquiring more accurate motor patterns. In this case series, three participants ages 10-14 years diagnosed with CAS attended 16 h of speech therapy over a 2-week period to address residual speech sound errors. Two participants had distortions on rhotic sounds, while the third participant demonstrated lateralization of sibilant sounds. During therapy, cues were provided to assist participants in obtaining a tongue shape that facilitated a correct production of the erred sound. Additional practice without ultrasound was also included. Results suggested that all participants showed signs of acquisition of sounds in error. Generalization and retention results were mixed. One participant showed generalization and retention of sounds that were treated; one showed generalization but limited retention; and the third showed no evidence of generalization or retention. Individual characteristics that may facilitate generalization are discussed. Short-term intensive treatment programs using ultrasound biofeedback may result in the acquisition of more accurate motor patterns and improved articulation of sounds previously in error, with varying levels of generalization and retention.
Single-point single-molecule FRAP distinguishes inner and outer nuclear membrane protein distribution
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2016
Subjects: Biological Transport
Endoplasmic Reticulum
Feasibility Studies
Fluorescence Recovery After Photobleaching
HeLa Cells
Humans
Membrane Proteins
Microscopy, Confocal
Microscopy, Fluorescence
Nuclear Envelope
Single Molecule Imaging

description: © The Author(s) 2016. The normal distribution of nuclear envelope transmembrane proteins (NETs) is disrupted in several human diseases. NETs are synthesized on the endoplasmic reticulum and then transported from the outer nuclear membrane (ONM) to the inner nuclear membrane (INM). Quantitative determination of the distribution of NETs on the ONM and INM is limited in available approaches, which moreover provide no information about translocation rates in the two membranes. Here we demonstrate a single-point single-molecule FRAP microscopy technique that enables determination of distribution and translocation rates for NETs in vivo.
Analytic theory of nonlinearly coupled electrokinetics in nanochannels
Creators: name: Uematsu, Yuki
Publisher: name: arXiv
Year: 2023
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Soft Condensed Matter (cond-mat.soft)
subject: Chemical Physics (physics.chem-ph)
subject: FOS: Physical sciences

description: The nonlinear electrokinetic response of ionic solutions is important in nanofluidics. However, quantitatively understanding the mechanisms is still a challenging problem because of a lack of analytic approaches. Here, a general framework for calculating the nonlinear electrokinetic coefficients of strongly confined electrolytes is constructed using a perturbation scheme of the pressure and voltage differences across a nanochannel. The theory is applied to an electrically neutral nanochannel filled with electrolytes, and analytic expressions for the first- and third-order electrokinetic coefficients are obtained. We demonstrate that the combination of high hydrodynamic permeability and ion-wall friction plays an essential role in nonlinear electrokinetics. Furthermore, we analytically demonstrate that the external flow induces uniform excess charge inside the nanochannel.
description: 9 pages, 4pages for SI, accepted version
There was movement that was stationary, for the four-velocity had passed around
Creators: name: Roukema, Boudewijn F.
Publisher: name: arXiv
Year: 2009
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Is the Doppler interpretation of galaxy redshifts in a Friedmann-Lemaitre-Robertson-Walker (FLRW) model valid in the context of the approach to comoving spatial sections pioneered by de Sitter, Friedmann, Lemaitre and Robertson, i.e. according to which the 3-manifold of comoving space is characterised by both its curvature and topology? Holonomy transformations for flat, spherical and hyperbolic FLRW spatial sections are proposed. By quotienting a simply-connected FLRW spatial section by an appropriate group of holonomy transformations, the Doppler interpretation in a non-expanding Minkowski space-time, obtained via four-velocity parallel transport along a photon path, is found to imply that an inertial observer is receding from herself at a speed greater than zero, implying contradictory world-lines. The contradiction in the multiply-connected case occurs for arbitrary redshifts in the flat and spherical cases, and for certain large redshifts in the hyperbolic case. The link between the Doppler interpretation of redshifts and cosmic topology can be understood physically as the link between parallel transport along a photon path and the fact that the comoving spatial geodesic corresponding to a photon's path can be a closed loop in an FLRW model of any curvature. Closed comoving spatial loops are fundamental to cosmic topology.
description: 8 pages, 2 figures; v2: missing dot added to Defn 1, minor corrections; submitted to MNRAS
Axios/Ipsos Coronavirus Index Wave 51
Creators: name: Axios
Publisher: name: Roper Center for Public Opinion Research
Year: 2021

description: Changes in health in last week (2); activities in last week (5); changes in work and household over last few weeks (6); risk of different activities (6); safety procedures when leaving the house (2); concern about coronavirus (COVID-19) outbreak (1); Delta variant of coronavirus (1); trust in organizations/politicians to provide accurate information about coronavirus (9); coronavirus vaccine (4); information about coronavirus (7); public health mandates (5); coronavirus testing (6); main source of news (1).
Cascade Synthesis of Pyrroles from Nitroarenes with Benign Reductants Using a Heterogeneous Cobalt Catalyst
Creators: name: Ryabchuk, Pavel
name: Leischner, Thomas
name: Kreyenschulte, Carsten
name: Spannenberg, Anke
name: Junge, Kathrin
name: Beller, Matthias
Publisher: name: Weinheim : Wiley-VCH
Year: 2020
Subjects: subject: cobalt
subject: heterogeneous catalysis
subject: hydrogenation
subject: nitroarene
subject: pyrrole
subject: 540

description: A bifunctional 3d-metal catalyst for the cascade synthesis of diverse pyrroles from nitroarenes is presented. The optimal catalytic system Co/NGr-C@SiO2-L is obtained by pyrolysis of a cobalt-impregnated composite followed by subsequent selective leaching. In the presence of this material, (transfer) hydrogenation of easily available nitroarenes and subsequent Paal–Knorr/Clauson-Kass condensation provides >40 pyrroles in good to high yields using dihydrogen, formic acid, or a CO/H2O mixture (WGSR conditions) as reductant. In addition to the favorable step economy, this straightforward domino process does not require any solvents or external co-catalysts. The general synthetic utility of this methodology was demonstrated on a variety of functionalized substrates including the preparation of biologically active and pharmaceutically relevant compounds, for example, (+)-Isamoltane. © 2020 The Authors. Published by Wiley-VCH GmbH
On an additive partial correlation operator and nonparametric estimation of graphical models
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2016
Subjects: Additive conditional covariance operator
Additive conditional independence
Copula
Gaussian graphical model
Partial correlation
Reproducing kernel

description: © 2016 Biometrika Trust. We introduce an additive partial correlation operator as an extension of partial correlation to the nonlinear setting, and use it to develop a new estimator for nonparametric graphical models. Our graphical models are based on additive conditional independence, a statistical relation that captures the spirit of conditional independence without having to resort to high-dimensional kernels for its estimation. The additive partial correlation operator completely characterizes additive conditional independence, and has the additional advantage of putting marginal variation on appropriate scales when evaluating interdependence, which leads to more accurate statistical inference. We establish the consistency of the proposed estimator. Through simulation experiments and analysis of the DREAM4 Challenge dataset, we demonstrate that our method performs better than existing methods in cases where the Gaussian or copula Gaussian assumption does not hold, and that a more appropriate scaling for our method further enhances its performance.
e-DIPLOMA - Deliverable 1.3: Data Management Plan
Creators: name: Stylianou, Kleovoulos
Publisher: name: Zenodo
Year: 2023
Subjects: data management plan
data
data management
e-learning
artificial intelligence
virtual reality
augmented reality
focus gropus
hackathons

description: This document is the Deliverable 1.3 "Data Management Plan" of the e-DIPLOMA project.

This deliverable is developed in the context of Work Package 1 (WP1): Project Management of the Project. The main aim of the Data Management Plan (DMP) is to describe the data management life cycle for the data to be re-use, collected, processed and/or generated during the e-DIPLOMA project. Within Horizon Europe, good research data management is viewed as the key conduit leading to knowledge discovery and innovation, and to subsequent data and knowledge integration and reuse. A robust DMP is the backbone of this, outlining how data is to be handled both during the project life and after its completion and setting out the principles and procedures to ensure that data is well-managed in the present and prepared for preservation in the future. An essential aspect of the DMP is the introduction of appropriate controls related to data privacy issues. Furthermore, as per the Grant Agreement (Article 17), a key guiding principle of Horizon Europe projects is making research data generated from said projects findable, accessible, interoperable, and reusable (FAIR); to accomplish this, a DMP should include information on:

The handling of research data during & after the end of the project

What data will be generated, collected, processed and/or re-used

Which methodology & standards will be applied

Whether data will be shared/made open access and

How data will be curated & preserved (including after the end of the project).
The effect of thymectomy on the course of experimental immune thyroiditis in mice
Creators: name: Hay, John Bruce
Publisher: name: University of British Columbia
Year: 2011

description: The purpose of this project was to experimentally induce thyroiditis in the mouse and to examine any influence thymectomy might have on its development. Immunization was performed using homologous thyroid extract emulsified in Freund's adjuvant. The mice were thymectomized within 18 hours of birth using a suction technique. Results indicated that the incidence of thyroid lesions were reduced by 25 per cent with thymectomy. Serum antibody levels of an anti-thyroid nature were not reduced, however, as detected by a tanned cell haemagglutination technique. These results are in accordance with recent evidence that the thymus is important in the development of cellular immunity while immunoglobulin production is dependent on a separate immune system probably involving the bursa of Fabricius in chickens or its homologue in mammals.
Slip line growth as a critical phenomenon
Creators: name: Leoni, Fabio
name: Zapperi, Stefano
Publisher: name: arXiv
Year: 2008
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We study the growth of slip line in a plastically deforming crystal by numerical simulation of a double-ended pile-up model with a dislocation source at one end, and an absorbing wall at the other end. In presence of defects, the pile-up undergoes a second order non-equilibrium phase transition as a function of stress, which can be characterized by finite size scaling. We obtain a complete set of critical exponents and scaling functions that describe the spatiotemporal dynamics of the slip line. Our findings allow to reinterpret earlier experiments on slip line kinematography as evidence of a dynamic critical phenomenon.
description: 4 pages, 4 figures
Ostwald ripening of aqueous microbubble solutions
Creators: name: Inoue, Sota
name: Kimura, Yasuyuki
name: Uematsu, Yuki
Publisher: name: arXiv
Year: 2023
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: Bubble solutions are of growing interest because of various technological applications in surface cleaning, water treatment, and agriculture. However, their physicochemical properties such as the stability and interfacial charge of bubbles are not fully understood yet. In this study, the kinetics of radii in aqueous microbubble solutions are experimentally investigated, and the results are discussed in the context of Ostwald ripening. The obtained distributions of bubble radii scaled by mean radius and total number were found to be time-independent during the observation period. Image analysis of radii kinetics revealed that the average growth and shrinkage speed of each bubble is governed by diffusion-limited Ostwald ripening, and the kinetic coefficient calculated using the available physicochemical constants in literature quantitatively agrees with the experimental data. Furthermore, the cube of mean radius and mean volume exhibit a linear time evolution in agreement with the Lifshitz-Slezov-Wagner (LSW) theory. The coefficients are slightly larger than those predicted using the LSW theory, which can be qualitatively explained by the effect of finite volume fraction. Finally, the slow down and pinning of radius in the shrinkage dynamics of small microbubbles are discussed in detail.
description: 10 pages, accepted version
Exploring the Paradox: Women's Political Engagement and Under-representation in Indian Politics
Creators: name: kumar, vikash
Publisher: name: figshare
Year: 2023
Subjects: classificationCode: 440806
subject: Gender and politics
classificationCode: 440305
subject: Population trends and policies

description: This article undertakes a comprehensive analysis of women's political involvement and representation, tracing their journey from being constituents to voters, from aspiring candidates to political representatives. It argues that a complex interplay of social, cultural, and political factors contributes to a democratic deficit for women within the government. Despite their omnipresence in the political arena, their representation in crucial positions and at the highest decision-making levels remains disproportionately low.While there has been an uptick in women's voter turnout in both assembly and general elections, the number of women actively participating as candidates in the electoral process remains limited, and the count of women legislators is even more scarce. Furthermore, this article delves into the enduring issue of underrepresentation of Muslim women in politics, highlighting the multiple layers of marginalization they face.
Adjacency Matrix based method to compute the node connectivity of a Computer Communication Network
Creators: name: Kamalesh, V. N
name: Srivatsa, S. K.
Publisher: name: arXiv
Year: 2010
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Paper has been withdrawn due to non-compliance with IJCSI terms and conditions.
description: Paper has been withdrawn due to non-compliance with IJCSI terms and conditions.
TRPV1: A target for rational drug design
Creators: name: (:Unkn) Unknown
Publisher: name: My University
Year: 2016
Subjects: TRPV1
capsaicin
nociception
pain
vanilloid

description: © 2016 by the authors; licensee MDPI, Basel, Switzerland. Transient Receptor Potential Vanilloid 1 (TRPV1) is a non-selective, Ca2+ permeable cation channel activated by noxious heat, and chemical ligands, such as capsaicin and resiniferatoxin (RTX). Many compounds have been developed that either activate or inhibit TRPV1, but none of them are in routine clinical practice. This review will discuss the rationale for antagonists and agonists of TRPV1 for pain relief and other conditions, and strategies to develop new, better drugs to target this ion channel, using the newly available high-resolution structures.