cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Detection of hepatitis B virus in serum using amplification of viral DNA by means of the polymerase chain reaction
Creators: name: Sumazaki, R.
name: Motz, M.
name: Wolf, Hans
name: Heinig, J.
name: Jilg, Wolfgang
name: Deinhardt, F.
Publisher: name: Universität Regensburg
Year: 1989
Subjects: subject: 610 Medizin
subject: Antibodies, Viral/immunology
subject: Blotting, Southern
subject: DNA Probes
subject: DNA, Viral/biosynthesis
subject: DNA-Directed DNA Polymerase/metabolism
subject: Electrophoresis, Agar Gel
subject: Gene Amplification
subject: Hepatitis Antibodies/analysis
subject: Hepatitis B/diagnosis
subject: Hepatitis B Antigens/immunology
subject: Hepatitis B virus/isolation & purification
subject: Humans
subject: Immune Sera/analysis
subject: Methods
subject: Plasmids
subject: Sensitivity and Specificity
subject: Serologic Tests
subject: Taq Polymerase

description: A new assay was developed for the detection of hepatitis B virus (HBV) in human serum using amplification of a short viral DNA sequence by means of the polymerase chain reaction. As little as 0.4 fg viral DNA, corresponding to about 130 genome equivalents, per ml serum could be detected after the amplification procedure. This assay detected viral DNA in a number of patients with proven or suspected chronic HBV infection who were all negative for HBV DNA in the conventional hybridisation assay. We found HBV DNA in all of six HBeAg-positive and in three of eight HBeAg-negative HBsAg carriers, as well as in all of 11 patients with chronic liver disease with antibodies against the HBV core antigen (anti-HBc) as the sole marker for HBV infection, and in three of five apparently healthy individuals showing only anti HBc. Thus, this method is an important improvement for the diagnosis of persistent HBV infections, especially in patients where a definitive serological diagnosis is not possible.
Quantum Torus symmetry of the KP, KdV and BKP hierarchies
Creators: name: Li, Chuanzhong
name: He, Jingsong
Publisher: name: arXiv
Year: 2013
Subjects: subject: Mathematical Physics (math-ph)
subject: Exactly Solvable and Integrable Systems (nlin.SI)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: In this paper, we construct the quantum Torus symmetry of the KP hierarchy and further derive the quantum torus constraint on the tau function of the KP hierarchy. That means we give a nice representation of the quantum Torus Lie algebra in the KP system by acting on its tau function. Comparing to the $W_{\infty}$ symmetry, this quantum Torus symmetry has a nice algebraic structure with double indices. Further by reduction, we also construct the quantum Torus symmetries of the KdV and BKP hierarchies and further derive the quantum Torus constraints on their tau functions. These quantum Torus constraints might have applications in the quantum field theory, supersymmetric gauge theory and so on.
description: published in Lett. Math. Phys. online ahead of print 15 August 2014
Progress towards quantum simulating the classical O(2) model
Creators: name: Zou, Haiyuan
name: Liu, Yuzhi
name: Lai, Chen-Yen
name: Unmuth-Yockey, J.
name: Yang, Li-Ping
name: Bazavov, A.
name: Xie, Z. Y.
name: Xiang, T.
name: Chandrasekharan, S.
name: Tsai, S. -W.
name: Meurice, Y.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We connect explicitly the classical $O(2)$ model in 1+1 dimensions, a model sharing important features with $U(1)$ lattice gauge theory, to physical models potentially implementable on optical lattices and evolving at physical time. Using the tensor renormalization group formulation, we take the time continuum limit and check that finite dimensional projections used in recent proposals for quantum simulators provide controllable approximations of the original model. We propose two-species Bose-Hubbard models corresponding to these finite dimensional projections at strong coupling and discuss their possible implementations on optical lattices using a $^{87}$Rb and $^{41}$K Bose-Bose mixture.
description: 7 pages, 6 figures, uses revtex, new material and one author added, as to appear in Phys. Rev. A
Oral hairy leukoplakia: observations in 95 cases and review of the literature
Creators: name: Reichart, P. A.
name: Langford, A.
name: Gelderblom, H. R.
name: Pohle, H. D.
name: Becker, J.
name: Wolf, Hans J.
Publisher: name: Universität Regensburg
Year: 1989
Subjects: subject: 610 Medizin
subject: Adult
subject: Aged
subject: Aged, 80 and over
subject: Female
subject: HIV Seropositivity
subject: Herpesvirus 4, Human
subject: Humans
subject: Leukoplakia, Oral/pathology
subject: Male
subject: Middle Aged
subject: Risk Factors
subject: T-Lymphocytes, Helper-Inducer/pathology
subject: T-Lymphocytes, Regulatory/pathology
subject: Tongue Neoplasms/pathology
subject: Tumor Virus Infections/pathology

description: Oral hairy leukoplakia (HL) was observed in 25.4% of 373 HIV-seropositive patients (n = 95). 87 were men of an average age of 37.1 yr, 8 were women (30.3 yr). 71.6% of the patients were male homosexuals. At initial diagnosis of HL the majority of cases was classified as CDC IVc1 (45.3%) and CDC II (22.1%). Average CD4/CD8 ratio (n = 19) was 0.24 with a range of 0.04-1.0. Thirty biopsies of HL revealed some of the histologic features thought to be characteristic. In only 20 of 30 biopsies EB-virus-specific-capsid antigen was detected. The problems of clinical and histological diagnosis of HL are discussed. Further strict criteria are necessary in order to define HL more distinctly.
Scalar strangeness content of the nucleon and baryon sigma terms
Creators: name: Ren, Xiu-Lei
name: Geng, Li-Sheng
name: Meng, Jie
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Lattice (hep-lat)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The scalar strangeness content of the nucleon, characterized by the so-called strangeness-nucleon sigma term, is of fundamental importance in understanding its sea-quark flavor structure. We report a determination of the octet baryon sigma terms via the Feynman-Hellmann theorem by analyzing the latest high-statistics $n_f=2+1$ lattice QCD simulations with covariant baryon chiral perturbation theory up to next-to-next-to-next-to-leading order. In particular, we predict $σ_{πN}=55(1)(4)$ MeV and $σ_{sN}=27(27)(4)$ MeV, while the first error is statistical and the second systematic due to different lattice scales. The predicted $σ_{sN}$ is consistent with the latest LQCD results and the results based on the next-to-next-to-leading order chiral perturbation theory. Several key factors in determining the sigma terms are systematically taken into account and clarified for the first time, including the effects of lattice scale setting, systematic uncertainties originating from chiral expansion truncations, and constraint of strong-interaction isospin breaking effects.
description: 6 pages, 2 figures; version to appear in Physical Review D
Online Matrix
Creators: name: Université Savoie Mont Blanc
Publisher: name: Zenodo
Year: 2021
Subjects: matrix

description: This document outlines the implementation of “the matrix” as the basic material used for
 developing faster recognition tracks.
 The content of the matrix is gathered in a spreadsheet, available on the Datacloud WP2
 folder.
description: UNITA Grant number 101004082
Between quantum and classical gravity: Is there a mesoscopic spacetime?
Creators: name: Di Casola, Eolo
name: Liberati, Stefano
name: Sonego, Sebastiano
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Between the microscopic domain ruled by quantum gravity, and the macroscopic scales described by general relativity, there might be an intermediate, "mesoscopic" regime, where spacetime can still be approximately treated as a differentiable pseudo-Riemannian manifold, with small corrections of quantum gravitational origin. We argue that, unless one accepts to give up the relativity principle, either such a regime does not exist at all (hence, the quantum-to-classical transition is sharp), or the only mesoscopic, tiny corrections conceivable are on the behaviour of physical fields, rather than on the geometric structures.
description: 7 pages, no figures
Serodiagnosis of infectious mononucleosis by using recombinant Epstein-Barr virus antigens and enzyme-linked immunosorbent assay technology
Creators: name: Gorgievski-Hrisoho, M.
name: Hinderer, W.
name: Nebel-Schickel, H.
name: Horn, J.
name: Vornhagen, R.
name: Sonneborn, H. H.
name: Wolf, Hans J.
name: Siegl, G.
Publisher: name: Universität Regensburg
Year: 1990
Subjects: subject: 610 Medizin
subject: Adolescent
subject: Adult
subject: Antibodies, Viral/blood
subject: Antigens, Viral
subject: Biological Markers/blood
subject: Child
subject: Child, Preschool
subject: Enzyme-Linked Immunosorbent Assay
subject: Evaluation Studies as Topic
subject: Female
subject: Herpesvirus 4, Human/immunology
subject: Humans
subject: Immunoglobulin G/analysis
subject: Immunoglobulin M/analysis
subject: Infectious Mononucleosis/immunology
subject: Male
subject: Serologic Tests
subject: Viral Proteins/immunology

description: Four recombinant, diagnostically useful Epstein-Barr virus (EBV) proteins representative of the viral capsid antigen (p150), diffuse early antigen (p54), the major DNA-binding protein (p138), and the EBV nuclear antigen (p72) (W. Hinderer, H. Nebel-Schickel, H.H. Sonneborn, M. Motz, R. Kühbeck, and H. Wolf, J. Exp. Clin. Cancer Res. 7[Suppl.]:132, 1988) were used to set up individual enzyme-linked immunosorbent assays (ELISAs) for the qualitative and quantitative detection of immunoglobulin M (IgM) and IgG antibodies. In direct comparison with results obtained by standard immunofluorescence or immunoperoxidase assays, it was then shown that the recombinant EBV ELISAs provide the means for specific and sensitive serodiagnosis of infectious mononucleosis (IM) caused by EBV. The most useful markers in sera from such patients proved to be IgM antibodies against p54, p138, and p150. Additional positive markers for recent or ongoing IM apparently were IgG antibodies against p54 and p138. In contrast, anti-p72 IgG had a high preference for sera from healthy blood donors and, therefore, can be considered indicative of past exposure to the virus. Altogether, the individual ELISAs proved to be as specific and at least as sensitive for the diagnosis of IM as the currently available standard techniques are. Moreover, our findings suggest that, by combining individual test antigens, a workable ELISA system consisting of three assays (IgM against p54, p138, and p150; IgG against p54 and p138; and IgG against p72) can be established for the standardized rapid diagnosis of acute EBV infections.
Direct observation of the injection dynamics of a laser wakefield accelerator using few-femtosecond shadowgraphy
Creators: name: Sävert, A.
name: Mangles, S. P. D.
name: Schnell, M.
name: Siminos, E.
name: Cole, J. M.
name: Leier, M.
name: Reuter, M.
name: Schwab, M. B.
name: Möller, M.
name: Poder, K.
name: Jäckel, O.
name: Paulus, G. G.
name: Spielmann, C.
name: Skupin, S.
name: Najmudin, Z.
name: Kaluza, M. C.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: Accelerator Physics (physics.acc-ph)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We present few-femtosecond shadowgraphic snapshots taken during the non-linear evolution of the plasma wave in a laser wakefield accelerator with transverse synchronized few-cycle probe pulses. These snapshots can be directly associated with the electron density distribution within the plasma wave and give quantitative information about its size and shape. Our results show that self-injection of electrons into the first plasma wave period is induced by a lengthening of the first plasma period. Three dimensional particle in cell simulations support our observations.
description: 5 pages, 4 figures
Some curvature problems in semi-Riemannian geometry
Creators: name: Finster, Felix
name: Nardmann, Marc
Publisher: name: Universität Regensburg
Year: 2010
Subjects: subject: 510 Mathematik

description: In this survey article we review several results on the curvature of semi-Riemannian metrics which are motivated by the positive mass theorem. The main themes are estimates of the Riemann tensor of an asymptotically flat manifold and the construction of Lorentzian metrics which satisfy the dominant energy condition.
Quantum non-Gaussian Depth of Single-Photon States
Creators: name: Straka, Ivo
name: Predojević, Ana
name: Huber, Tobias
name: Lachman, Lukáš
name: Butschek, Lorenz
name: Miková, Martina
name: Mičuda, Michal
name: Solomon, Glenn S.
name: Weihs, Gregor
name: Ježek, Miroslav
name: Filip, Radim
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: We introduce and experimentally explore the concept of quantum non-Gaussian depth of single-photon states with a positive Wigner function. The depth measures the robustness of a single-photon state against optical losses. The directly witnessed quantum non-Gaussianity withstands significant attenuation, exhibiting a depth of 18 dB, while the nonclassicality remains unchanged. Quantum non-Gaussian depth is an experimentally approachable quantity that is much more robust than the negativity of the Wigner function. Furthermore, we use it to reveal significant differences between otherwise strongly nonclassical single-photon sources.
description: 6 pages, 3 figures, 1 onion
Données, métadonnées, partage & réutilisation : cas de la dynamique moléculaire
Creators: name: Poulain, Pierre
Publisher: name: Zenodo
Year: 2023

description: Présentation donnée lors de l'évènement "Le BIG Day" organisé par l'association e-BIGO des étudiants en bioinformatique de l'Université Rennes 1.
https://ebigo-rennes.jimdofree.com/big-day/
Mass endomorphism, surgery and perturbations
Creators: name: Ammann, Bernd
name: Dahl, Mattias
name: Hermann, Andreas
name: Humbert, Emmanuel
Publisher: name: Universität Regensburg
Year: 2010
Subjects: subject: 510 Mathematik

description: We prove that the mass endomorphism associated to the Dirac operator on a Riemannian manifold is non-zero for generic Riemannian metrics. The proof involves a study of the mass endomorphism under surgery, its behavior near metrics with harmonic spinors, and analytic perturbation arguments.
Enhancing public research on citizen data: An empirical investigation of data synthesis using Statistics New Zealand’s Integrated Data Infrastructure
Creators: name: Wang, Xing
name: Chukova, Stefanka S
name: Sporle, Andrew
name: Milne, Barry J
name: Simpson, Colin R
name: Nguyen, Binh
Publisher: name: Open Access Te Herenga Waka-Victoria University of Wellington
Year: 2023
Subjects: classificationCode: 4609
subject: Information systems
classificationCode: 4610
subject: Library and information studies

description: No description supplied
New class of rotating perfect fluid black holes in three dimensional gravity
Creators: name: Wu, Bin
name: Xu, Wei
Publisher: name: arXiv
Year: 2013
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We obtain a new class of rotating black holes for Einstein theory with perfect fluid source in (2+1) dimensions. We conclude that these black hole solutions only depend on variable angular velocity $m(r)$. Some examples of these black holes are given explicitly. In particular, the unknown static black hole in this special background is obtained. In addition, the general properties including the horizon structure, energy conditions and equation of state, mass and angular momentum are explained in detail.
description: 12 pages, no figures; a few references added and typos corrected; published version
Regularity for eigenfunctions of Schrödinger operators
Creators: name: Ammann, Bernd
name: Carvalho, Catarina
name: Nistor, Victor
Publisher: name: Universität Regensburg
Year: 2010
Subjects: subject: 510 Mathematik

description: We prove a regularity result in weighted Sobolev (or Babuˇska–Kondratiev) spaces for the eigenfunctions of a single-nucleus Schr¨odinger operator. More precisely, let Km a (R3N) be the weighted Sobolev space obtained by blowing up the set of singular points of the potential V (x) = Σ 1jN bj jxj j + Σ 1i
Nonlinear Young integrals and differential systems in Hölder media
Creators: name: Hu, Yaozhong
name: Lê, Khoa N.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Probability (math.PR)
subject: Analysis of PDEs (math.AP)
subject: FOS: Mathematics

description: For Hölder continuous functions $W(t,x)$ and $ϕ_t$, we define nonlinear integral $\int_a^b W(dt, ϕ_t)$ in various senses, including Itô-Skorohod and pathwise. We study their properties and relations. The stochastic flow in a time dependent rough vector field associated with $\dot ϕ_t=(\partial _tW)(t, ϕ_t)$ is also studied and its applications to the transport equation $\partial _t u(t,x)-\partial _t W(t,x)\nabla u(t,x)=0$ in rough media is given. The Feynman-Kac solution to the stochastic partial differential equation with random coefficients $\partial _t u(t,x)+Lu(t,x) +u(t,x)W(t,x)=0$ are given, where $L$ is a second order elliptic differential operator with random coefficients (dependent on $W$). To establish such formula the main difficulty is the exponential integrability of some nonlinear integrals, which is proved to be true under some mild conditions on the covariance of $W$. Along the way, we also obtain an upper bound for increments of stochastic processes on multidimensional rectangles by majorizing measures.
Combinatorial model for cluster categories of type E
Creators: name: Lamberti, Lisa
Publisher: name: arXiv
Year: 2014
Subjects: subject: Representation Theory (math.RT)
subject: FOS: Mathematics

description: In this paper we give a geometric-combinatorial description of the cluster categories of type E. In particular, we give an explicit geometric description of all cluster tilting objects in the cluster category of type E_6. The model we propose here arises from combining two polygons, and it generalises the description of the cluster category of type A and D.
description: Following the suggestion of the referee we significantely extended Section 3, 4 and 6. To appear in the Journal of Algebraic Combinatorics
A remark on the rigidity case of the positive energy theorem
Creators: name: Nardmann, Marc
Publisher: name: Universität Regensburg
Year: 2010
Subjects: subject: 510 Mathematik

description: In their proof of the positive energy theorem, Schoen and Yau showed that every asymptotically flat spacelike hypersurface M of a Lorentzian manifold which is flat along M can be isometrically imbedded with its given second fundamental form into Minkowski spacetime as the graph of a function Rn ! R; in particular,M is diffeomorphic to Rn. In this short note, we give an alternative proof of this fact. The argument generalises to the asymptotically hyperbolic case, works in every dimension n, and does not need a spin structure.
A hierarchy of bound states in the 1D ferromagnetic Ising chain CoNb$_2$O$_6$ investigated by high resolution time-domain terahertz spectroscopy
Creators: name: Morris, C. M.
name: Aguilar, R. Valdés
name: Ghosh, A.
name: Koohpayeh, S. M.
name: Krizan, J.
name: Cava, R. J.
name: Tchernyshyov, O.
name: McQueen, T. M.
name: Armitage, N. P.
Publisher: name: arXiv
Year: 2013
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: Kink bound states in the one dimensional ferromagnetic Ising chain compound CoNb$_2$O$_6$ have been studied using high resolution time-domain terahertz spectroscopy in zero applied magnetic field. When magnetic order develops at low temperature, nine bound states of kinks become visible. Their energies can be modeled exceedingly well by the Airy function solutions to a 1D Schrödinger equation with a linear confining potential. This sequence of bound states terminates at a threshold energy near two times the energy of the lowest bound state. Above this energy scale we observe a broad feature consistent with the onset of the two particle continuum. At energies just below this threshold we observe a prominent excitation that we interpret as a novel bound state of bound states -- two pairs of kinks on neighboring chains.
Sim-to-Lab-to-Real: Safe Reinforcement Learning with Shielding and Generalization Guarantees
Creators: name: Hsu, Kai-Chieh
name: Ren, Allen Z.
name: Nguyen, Duy Phuong
name: Majumdar, Anirudha
name: Fisac, Jaime F.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Robotics (cs.RO)
subject: Machine Learning (cs.LG)
subject: FOS: Computer and information sciences

description: Safety is a critical component of autonomous systems and remains a challenge for learning-based policies to be utilized in the real world. In particular, policies learned using reinforcement learning often fail to generalize to novel environments due to unsafe behavior. In this paper, we propose Sim-to-Lab-to-Real to bridge the reality gap with a probabilistically guaranteed safety-aware policy distribution. To improve safety, we apply a dual policy setup where a performance policy is trained using the cumulative task reward and a backup (safety) policy is trained by solving the Safety Bellman Equation based on Hamilton-Jacobi (HJ) reachability analysis. In Sim-to-Lab transfer, we apply a supervisory control scheme to shield unsafe actions during exploration; in Lab-to-Real transfer, we leverage the Probably Approximately Correct (PAC)-Bayes framework to provide lower bounds on the expected performance and safety of policies in unseen environments. Additionally, inheriting from the HJ reachability analysis, the bound accounts for the expectation over the worst-case safety in each environment. We empirically study the proposed framework for ego-vision navigation in two types of indoor environments with varying degrees of photorealism. We also demonstrate strong generalization performance through hardware experiments in real indoor spaces with a quadrupedal robot. See https://sites.google.com/princeton.edu/sim-to-lab-to-real for supplementary material.
description: Accepted to Special Issue on Risk-aware Autonomous Systems: Theory and Practice, Artificial Intelligence
title: A different language : implementing the total communication approach
Creators: name: Wilson, Charlotte
Publisher: name: Strathprints - University of Strathclyde
Year: 2013

description: The majority of people with a learning disability have a communication impairment; however, difficulties with communication are not limited to children with disabilities. In spite of this the importance of communication is often overlooked. This article explores the implementation of the total communication approach in a residential short breaks unit, as a way towards improving communication. In doing so it aims to provide a clearer understanding of the total communication approach, as a model that values all modes of communication. Through this, the impact of communication on efficacy, participation, meaning making, behaviour, containment, attachment, and relationships will be considered.
The Overeducated Employed in the Italian Regions  between 2018 and 2022
Creators: name: Leogrande, Angelo
Publisher: name: Zenodo
Year: 2023

description: Istat calculates the value of over-educated employees. The variable is defined as the percentage of employed people who have a higher educational qualification than the one best possessed to carry out that profession out of the total number of employed people. This variable is analysed for the 20 Italian regions from 2018 and 2022.
A direct quantitative measure of surface mobility in a glassy polymer
Creators: name: Chai, Yu
name: Salez, Thomas
name: McGraw, Joshua D.
name: Benzaquen, Michael
name: Dalnoki-Veress, Kari
name: Raphaël, Elie
name: Forrest, James A.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Other Condensed Matter (cond-mat.other)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: Thin polymer films have striking dynamical properties that differ from their bulk counterparts. With the simple geometry of a stepped polymer film on a substrate, we probe mobility above and below the glass transition temperature $T_{\textrm{g}}$. Above $T_{\textrm{g}}$ the entire film flows, while below $T_{\textrm{g}}$ only the near surface region responds to the excess interfacial energy. An analytical thin film model for flow limited to the free surface region shows excellent agreement with sub-$T_{\textrm{g}}$ data. The system transitions from whole film flow to surface localized flow over a narrow temperature region near the bulk $T_{\textrm{g}}$. The experiments and model provide a measure of surface mobility in a sample geometry where confinement and substrate effects are negligible. This fine control of the glassy rheology is of key interest to nanolithography among numerous other applications.
Expression of class I major histocompatibility complex antigens in Epstein-Barr virus-carrying lymphoblastoid cell lines and Burkitt lymphoma cells
Creators: name: Jilg, W.
name: Voltz, R.
name: Markert-Hahn, C.
name: Mairhofer, H.
name: Münz, I.
name: Wolf, Hans J.
Publisher: name: Universität Regensburg
Year: 1991
Subjects: subject: 610 Medizin
subject: Blotting, Northern
subject: Burkitt Lymphoma/immunology
subject: Cell Line
subject: Cell Transformation, Viral
subject: Electrophoresis, Gel, Two-Dimensional
subject: Histocompatibility Antigens Class I/metabolism
subject: Humans
subject: Interferon-gamma/pharmacology
subject: Lymphocytes/microbiology
subject: Major Histocompatibility Complex
subject: Molecular Weight
subject: Pokeweed Mitogens/pharmacology
subject: Precipitin Tests
subject: RNA, Messenger/genetics
subject: Tumor Virus Infections/immunology

description: Epstein-Barr virus (EBV) carrying lymphoblastoid cell lines (LCLs) and EBV-positive Burkitt lymphoma (BL) cells were compared for their expression of class I antigens of the major histocompatibility complex. Five common BL lines, LCLs, pokeweed mitogen-stimulated blasts and resting B-cells from healthy donors, and eight pairs of BL cells and LCLs, each pair originating from one patient, were tested. Quantitative analysis was performed using a radioimmunoassay; qualitative aspects were studied by one- and two-dimensional gel electrophoresis. In general, LCLs expressed significantly higher amounts of class I antigens than BL cells, the latter showing class I densities similar to or lower than peripheral resting B-cells. From analysis of the expression of class I-specific RNA, there is some evidence that class I antigen expression is regulated on the transcriptional level. In two BL cells studied, class I expression could be enhanced by gamma-interferon, whereas the corresponding LCLs seemed to be refractory to this treatment. One- and two-dimensional gel electrophoresis showed that in some BL lines, in addition to the generally lower class I expression, distinct class I specificities were down-regulated. None of these alterations in class I expression was EBV specific; however, they may well play a role in the recognition of BL cells and LCLs by cellular immune mechanisms. Thus, down-regulation of class I antigens may contribute to the resistance of BL cells to cytotoxic T-lymphocytes, whereas their enhanced expression may improve the recognition of EBV-infected LCLs.
Probing neutron-star matter in the lab: similarities and differences between binary mergers and heavy-ion collisions
Creators: name: Most, Elias R.
name: Motornenko, Anton
name: Steinheimer, Jan
name: Dexheimer, Veronica
name: Hanauske, Matthias
name: Rezzolla, Luciano
name: Stoecker, Horst
Publisher: name: arXiv
Year: 2022
Subjects: subject: Nuclear Theory (nucl-th)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Binary neutron-star mergers and heavy-ion collisions are related through the properties of the hot and dense nuclear matter formed during these extreme events. In particular, low-energy heavy-ion collisions offer exciting prospects to recreate such {extreme} conditions in the laboratory. However, it remains unexplored to what degree those collisions can actually reproduce hot and dense matter formed in binary neutron star mergers. As a way to understand similarities and differences between these systems, we {discuss their geometry and }perform a direct numerical comparison of the thermodynamic conditions probed in both collisions. To enable a direct comparison, we employ a finite-temperature equation of state able to describe the entire high-energy phase diagram of Quantum Chromodynamics. Putting side by side the evolution of both systems, we find that laboratory heavy-ion collisions at the energy range of $E_{\mathrm{lab}}=0.4 - 0.6\ A$ MeV probe (thermodynamic) states of matter that are very similar to those created in binary neutron-star mergers. These results can inform future low-energy heavy-ion collisions probing this regime.
description: 12 pages, 4 figures, accepted version
Immunocytochemical detection of herpes viruses in oral smears of HIV-infected patients
Creators: name: Langford, A.
name: Kunze, R.
name: Schmelzer, S.
name: Wolf, Hans J.
name: Pohle, H. D.
name: Reichart, P.
Publisher: name: Universität Regensburg
Year: 1992
Subjects: subject: 610 Medizin
subject: Adult
subject: Cell Nucleus/microbiology
subject: Cytodiagnosis
subject: Cytomegalovirus/isolation & purification
subject: Cytoplasm/microbiology
subject: DNA Probes
subject: DNA, Viral/analysis
subject: Female
subject: HIV Infections/pathology
subject: HIV Seropositivity/pathology
subject: Herpesvirus 4, Human/isolation & purification
subject: Humans
subject: Immunohistochemistry
subject: Keratinocytes/microbiology
subject: Leukoplakia, Oral/microbiology
subject: Male
subject: Nucleic Acid Hybridization
subject: Tongue/ultrastructure
subject: Tongue Neoplasms/microbiology
subject: Tumor Virus Infections/microbiology
subject: Viral Proteins/analysis

description: Cytologic smears (CS) were taken from the lateral border of the tongue of HIV-seropositive patients (HIV+) (n = 39) and of seronegative controls (HIV-) (n = 19) and examined by immunocytochemistry (APAAP) and in situ hybridization (ISH) (biotinylated DNA probes) for the presence of viral antigens/DNA of EBV and CMV. While none of the HIV controls showed positive results for EBV antigen, 61% (APAAP) resp. 79% (ISH) of oral epithelial cells in the group of HIV+ patients were EBV-positive. While all CS taken from areas with the clinical diagnosis of hairy leukoplakia (HL) were EBV positive (APAAP and/or ISH), the detection of EBV in CS from uninvolved oral mucosa seemed to be associated with the later development of HL. In the group of HIV+ patients the detection rate for CMV was about five times (APAAP) resp. three times (ISH) higher than in HIV- persons. This non-invasive technique seems to be a valuable tool to screen for viral antigens/genomes.
In the matter establishing standards and regulations to be followed by utilities engaged in the production, sale and distribution of gas: order, October 6th, 1911
Creators: name: No Name Supplied
Publisher: name: No Publisher Supplied
Year: 1911

description: State of New Jersey.Board of Public Utility Commissioners.In the matter establishing standards and regulations to be followed by utilities engaged in the production, sale and distribution of gas. Order, October 6th, 1911.
Subcellular distribution and life cycle of Epstein-Barr virus in keratinocytes of oral hairy leukoplakia
Creators: name: Rabanus, J. P.
name: Greenspan, D.
name: Petersen, V.
name: Leser, Ulrike
name: Wolf, Hans J.
name: Greenspan, J. S.
Publisher: name: Universität Regensburg
Year: 1991
Subjects: subject: 610 Medizin
subject: Adult
subject: Antigens, Viral/analysis
subject: Capsid/immunology
subject: DNA/analysis
subject: Herpesvirus 4, Human/physiology
subject: Humans
subject: Immune Sera/immunology
subject: Keratinocytes/ultrastructure
subject: Leukoplakia, Oral/pathology
subject: Male
subject: Microscopy, Immunoelectron
subject: Papillomaviridae/immunology
subject: Subcellular Fractions/microbiology

description: The authors investigated the life cycle of Epstein-Barr virus (EBV) in keratinocytes of oral hairy leukoplakia by combining immunohistochemistry. DNA in situ hybridization, and lectin histochemistry with electron microscopy. Diffuse-staining components of the EBV early antigen complex (EA-D), EBV 150-kd capsid antigen (VCA), EBV membrane antigen (gp350/220), and double-stranded DNA were labeled with monoclonal antibodies. An EBV-DNA probe was used to locate EBV DNA. Wheat-germ agglutinin (WGA) was employed to distinguish Golgi-associated compartments. The authors found EBV proteins and EBV DNA only in keratinocytes with apparent viral assembly. In situ hybridization showed EBV DNA in free corelike material and in electron-dense cores of mature nucleocapsids. Monoclonal antibodies to nonspecific double-stranded DNA attached to the same structures and to marginated chromatin. Components of EA-D were dispersed throughout the nuclei but accumulated near condensed chromatin and in 'punched-out' regions of the chromatin. Epstein-Barr virus 150-kd capsid antigen was found only in the nuclei, where it appeared preferentially on mature nucleocapsids. As yet unexplained arrays of intranuclear particles that remained unlabeled with all EBV-specific probes reacted intensely with an antiserum against common papillomavirus antigen. Gp350/220 was detectable in various cellular membrane compartments and was highly concentrated on EBV envelopes in peripheral Golgi-associated secretory vesicles. It was less abundant on the extracellular EBV, indicating that viral membrane antigen partly dissociates from the mature virus. Combined lectin-binding histochemistry and electron microscopy demonstrated for the first time that EBV is processed in the Golgi apparatus, which eventually releases the virus by fusion with the plasma membrane. These results provide insight into the biologic events that occur during complete EBV replication in vivo.
Non-perturbative renormalization of overlap quark bilinears on 2+1-flavor domain wall fermion configurations
Creators: name: Liu, Zhaofeng
name: Chen, Ying
name: Dong, Shao-Jing
name: Glatzmaier, Michael
name: Gong, Ming
name: Li, Anyi
name: Liu, Keh-Fei
name: Yang, Yi-Bo
name: Zhang, Jian-Bo
Publisher: name: arXiv
Year: 2013
Subjects: subject: High Energy Physics - Lattice (hep-lat)
subject: FOS: Physical sciences

description: We present renormalization constants of overlap quark bilinear operators on 2+1-flavor domain wall fermion configurations. This setup is being used by the chiQCD collaboration in calculations of physical quantities such as strangeness in the nucleon and the strange and charm quark masses. The scale independent renormalization constant for the axial vector current is computed using the Ward Identity. The renormalization constants for scalar, pseudoscalar and vector current are calculated in the RI-MOM scheme. Results in the MS-bar scheme are also given. The step scaling function of quark masses in the RI-MOM scheme is computed as well. The analysis uses, in total, six different ensembles of three sea quarks each on two lattices with sizes 24^3x64 and 32^3x64 at spacings a=(1.73 GeV)^{-1} and (2.28 GeV)^{-1}, respectively.
description: 26 pages, 17 figures. More discussions on O(4) breaking effects, and on the perturbative running and a^2p^2 extrapolation of Zs. A subsection for the calculation of the step scaling function of quark mass is added. References added. Version to appear in PRD
Spin$^h$ Manifolds
Creators: name: Lawson, H. Blaine
Publisher: name: arXiv
Year: 2023
Subjects: subject: Differential Geometry (math.DG)
subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics
subject: 53C27, 55P99

description: The concept of a ${\rm Spin}^h$-manifold, which is a cousin of Spin- and ${\rm Spin}^c$-manifolds, has been at the center of much research in recent years. This article discusses some of the highlights of this story.
The Role of Law in the Treatment Decisions of Doctors
Creators: name: Dent, Chris
Publisher: name: Monash University
Year: 2023
Subjects: Other law and legal studies not elsewhere classified

description: The health system is complex. Regulating those who operate within it, however, is key to the effective promotion of the goals of the system. Regulating individuals can, in turn, be understood in terms of the regulation of their decisions. Julia Black’s ‘decentred regulation’, with her notion of the ‘ungovernable’ individual, is a step in the right path towards understanding the regulation of decisions, but it does not go far enough. With a discussion of the intersection of law and ideas from behavioural economics and psychology, this article explores the regulation of the health system in terms of the embedded decision-making of medical practitioners. The analysis will be rounded out with an assessment of four categories of decisions — conscientious objection, defensive medicine, decisions (properly seen as errors) that lead to patient harm and the prescription of ‘active placebos’.
Expression of proteins encoded by Epstein-Barr virus trans-activator genes depends on the differentiation of epithelial cells in oral hairy leukoplakia
Creators: name: Becker, J.
name: Leser, U.
name: Marschall, M.
name: Langford, A.
name: Jilg, Wolfgang
name: Gelderblom, H.
name: Reichart, P.
name: Wolf, Hans J.
Publisher: name: Universität Regensburg
Year: 1991
Subjects: subject: 610 Medizin
subject: Cell Differentiation
subject: DNA-Binding Proteins/metabolism
subject: Epithelium/pathology
subject: Fluorescent Antibody Technique
subject: Gene Expression Regulation, Viral
subject: Genes, Viral
subject: HIV Seropositivity/microbiology
subject: Herpesvirus 4, Human/genetics
subject: Humans
subject: Leukoplakia, Oral/pathology
subject: Mouth Mucosa/pathology
subject: Tongue/pathology
subject: Trans-Activators
subject: Viral Proteins/metabolism
subject: Viral Structural Proteins/genetics

description: The Epstein-Barr virus (EBV) immediate early gene product BZLF1 was localized by indirect immunofluorescence to the cytoplasm of the basal epithelial layer at the lateral border and dorsum of tongue in human immunodeficiency virus-infected and -seronegative patients. Two biopsies of oral hairy leukoplakia revealed a sporadic cytoplasmic staining of the BHRF1 and BRLF1 gene products in the basal epithelial layer. The widespread presence of BZLF1 in the basal epithelial layer indicated that this cell layer contained EBV DNA and was probably directly infected by EBV. Nuclear localization of the immediate early and early gene products BZLF1, BHRF1, BRLF1, and BMLF1 was limited to oral hairy leukoplakia in human immunodeficiency virus-seropositive patients and revealed a codistribution with the virus capsid antigen. Our results indicate that the epithelium of the tongue is a potential reservoir for EBV and that in heavily immunocompromised patients EBV may move from the cytoplasm to the nucleus with increasing differentiation and be coactivated there during the terminal differentiation of epithelial cells at the lateral border and dorsum of tongue.
Quantum spin Hall insulator on the honeycomb lattice induced by ferromagnetic exchange interaction
Creators: name: An, Ye-Un
name: O, Song-Jin
name: Ryom, Kwang-Il
name: Son, Il-Gwang
Publisher: name: arXiv
Year: 2023
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We study the many-body instabilities of correlated electrons on the half-filled honeycomb lattice with enhanced exchange coupling. The system is described by an extended Hubbard model including the next-nearest-neighbor Coulomb repulsion ($V_2$) and the nearest-neighbor exchange interaction ($J$). We use the truncated unity functional renormalization group approach to determine a schematic ground-state phase diagram with higher resolution in the parameter space of $V_2$ and $J$. In the absence of the on-site repulsion and presence of sizable next-nearest-neighbor repulsion and enhanced nearest-neighbor exchange interaction, we encounter the quantum spin Hall phase, the spin-Kekulé phase, and the three-sublattice and the incommensurate charge-density-wave phases. We propose a scheme for combining consistently the truncated unity functional renormalization group and the mean-field approximation, which is distinct from the conventional one that directly uses the renormalization-group results as an input for the mean-field calculation. This scheme is used to study in detail the quantum spin Hall phase, presenting some characteristics like the bulk gap, the Chern number and the helical edge states.
description: 17 pages, 6 figures, 1 table
Recombinant antigens in viral diagnosis
Creators: name: Vornhagen, R.
name: Baur, A.
name: Jahn, G.
name: Hinderer, W.
name: Nebel-Schickel, H.
name: Horn, J.
name: Wolf, Hans J.
name: Sonneborn, H. H.
Publisher: name: Universität Regensburg
Year: 1992
Subjects: subject: 610 Medizin
subject: Antibodies, Viral/analysis
subject: Antigens, Viral/diagnostic use
subject: Blotting, Western
subject: Enzyme-Linked Immunosorbent Assay
subject: Epitopes/immunology
subject: HIV Antibodies/analysis
subject: HIV-1/immunology
subject: HIV-2/immunology
subject: Herpesvirus 4, Human/immunology
subject: Humans
subject: Recombinant Proteins/diagnostic use

description: DNA fragments coding for a variety of different viral antigens have been cloned and expressed in Escherichia coli. Selected purified recombinant antigens were used for detection of specific antibodies by means of the ELISA technique. This approach has been used for the development of four different ELISAs for the detection of HIV- and EBV-specific antibodies.
Immunological reactivity of a human immunodeficiency virus type I derived peptide representing a consensus sequence of the GP120 major neutralizing region V3
Creators: name: Wagner, R.
name: Modrow, Susanne
name: Böltz, T.
name: Fliessbach, H.
name: Niedrig, M.
name: von Brunn, A.
name: Wolf, Hans J.
Publisher: name: Universität Regensburg
Year: 1992
Subjects: subject: 610 Medizin
subject: AIDS Vaccines/immunology
subject: Acquired Immunodeficiency Syndrome/immunology
subject: Amino Acid Sequence
subject: Antibodies, Monoclonal/immunology
subject: Consensus Sequence/immunology
subject: Cross Reactions
subject: HIV Antibodies/immunology
subject: HIV Envelope Protein gp120/immunology
subject: HIV-1/immunology
subject: Immunity, Cellular
subject: Molecular Sequence Data
subject: Neutralization Tests
subject: Peptides/immunology
subject: Sequence Alignment

description: To reduce the opportunities for human immunodeficiency virus type 1 (HIV-1) to evade vaccine induced immunity, the development of subunit vaccines must focus on the characterization of immunogenic epitopes, which are major targets for the immune system. The most dominant site for elicitation of neutralising immune response is located on the external envelope glycoprotein gp120 within the third variable domain (V3). To overcome virus type specificity of antibodies directed to the V3-domain we designed a 36 amino acids long gp120/V3-consensus peptide (V3-C36) based on published biological data and sequence comparisons of various HIV-1 virus isolates. This peptide contains a conserved core sequence which is suggested to form a surface-exposed beta-turn. This peptide also includes T-cell epitopes defined in mice and humans, an ADCC-epitope and two highly conserved cysteine residues which were oxidized to form a cystine derivate, thus allowing correct peptide folding. In ELISA-tests, this peptide reacts with at least 90% of randomly selected sera of European and African patients infected with HIV-1 and is recognized by three different HIV-1/V3 "type-specific" antisera (MN, RF, IIIB-strain). Using this peptide as immunogen in rabbits, antisera could be raised with highly cross-reactive and HIV-1/IIIB strain neutralizing properties. Moreover, HTLV/HIV-1/IIIB specific cytotoxic T-lymphocytes (CTLs) of BALB/c mice infected with a gp120 recombinant vaccinia virus recognized the central 16- and 12-mer peptides of the V3-C36 consensus peptide in cytolytic assays, indicating perfect compatibility of the consensus peptide with the IIIB-primed CTLs. The DNA-sequence encoding the V3-consensus loop region might be an important component in newly designed recombinant subunit vaccines. In addition, due to its broad serological reactivity, the V3-consensus peptide might play an important role in special diagnostic purposes.
Purification and quantification of recombinant Epstein-Barr viral glycoproteins gp350/220 from Chinese hamster ovary cells
Creators: name: Hessing, M.
name: van Schijndel, H. B.
name: van Grunsven, W. M.
name: Wolf, Hans J.
name: Middeldorp, J. M.
Publisher: name: Universität Regensburg
Year: 1992
Subjects: subject: 610 Medizin
subject: Animals
subject: Antigens, Viral/isolation & purification
subject: Blotting, Western
subject: CHO Cells
subject: Cricetinae
subject: Electrophoresis, Polyacrylamide Gel
subject: Enzyme-Linked Immunosorbent Assay
subject: Herpesvirus 4, Human/immunology
subject: Recombinant Proteins/isolation & purification
subject: Viral Envelope Proteins/isolation & purification
subject: Viral Matrix Proteins

description: Truncated Epstein-Barr virus (EBV) membrane antigen gp350/220 (EBV-MA) lacking the membrane anchor was expressed and secreted into the medium of recombinant Chinese hamster ovary cells that had been cultured in Plasmapur hollow-fibre modules using defined serum-free medium. The EBV-MA in the medium was concentrated by 70% (w/v) ammonium sulphate precipitation and subsequently purified by immunoaffinity chromatography using an anti-EBV-MA (EBV.0T6) monoclonal antibody (mAb) column. Adsorbed antigen was eluted with 3 M MgCl2 in phosphate-buffered saline, concentrated by Mono Q anion-exchange chromatography and analysed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis, silver staining and Western blotting using EBV-positive serum and anti-EBV-MA specific mAbs. Monospecific polyclonal rabbit antibodies against the purified EBV-MA were raised and purified by protein G affinity chromatography. For the measurement of EBV-MA antigen levels a sandwich enzyme-linked immunosorbent assay using rabbit polyclonal antibodies and a horseradish peroxidase-conjugated anti-MA mAb was developed having a detection level of 10 ng/ml.
2009-Brian_Winkel-Modelling_Growth_Of_an_OilSlick
Creators: name: Winkel, Brian
Publisher: name: QUBES Educational Resources
Year: 2023

description: An oil-slick spreads at sea. From time to time, but irregularly, a helicopter is dispatched. On each trip, it arrives over the slick, the pilot takes a picture, waits 10 minutes, takes another, and heads home. Model this.