title: ÐÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÐ¸ Ð¿Ð°ÑÐ°Ð¾ÐºÑÐ¾Ð½Ð°Ð·Ñ 1 (PON1) Ñ ÑÐ°Ð±Ð¾ÑÐ½Ð¸ÐºÐ¾Ð² Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ð¹, Ð¾Ð±ÐµÑÐ¿ÐµÑÐ¸Ð²Ð°ÑÑÐ¸Ñ Ñ ÑÐ°Ð½ÐµÐ½Ð¸Ðµ Ð¸ ÑÑÐ¸Ð»Ð¸Ð·Ð°ÑÐ¸Ñ ÑÐ¾ÑÑÐ¾ÑÐ¾Ð¾ÑÐ³Ð°Ð½Ð¸ÑÐµÑÐºÐ¸Ñ Ñ Ð¸Ð¼Ð¸ÐºÐ°ÑÐ¾Ð²
title: Ð±Ð°ÐºÐ°Ð»Ð°Ð²ÑÑÐºÐ°Ñ ÑÐ°Ð±Ð¾ÑÐ°
titleType: Subtitle
Creators: name: Ð Ð°Ð·Ð³Ð¸Ð»ÑÐ´Ð¸Ð½Ð°, ÐÐ°ÑÐ°Ð»ÑÑ
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2016
Subjects: Ð¿Ð°ÑÐ°Ð¾ÐºÑÐ¾Ð½Ð°Ð· 1 (PON1)
ÑÐ¾ÑÑÐ¾ÑÐ¾Ð¾ÑÐ³Ð°Ð½Ð¸ÑÐµÑÐºÐ¸Ðµ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ñ (Ð¤ÐÐ¡)
Ð³ÐµÐ½ PON1
Ð¿Ð¾Ð»Ð¸Ð¼Ð¾ÑÑÐ½ÑÐµ Ð²Ð°ÑÐ¸Ð°Ð½ÑÑ
paraoxonase 1 (PON1)
organophosphorus chemicals
paraoxonase 1 gen
polymorphic variants

description: Ð ÑÐ°Ð±Ð¾ÑÐµ Ð±ÑÐ»Ð¾ Ð¸Ð·ÑÑÐµÐ½Ð¾ Ð²Ð»Ð¸ÑÐ½Ð¸Ðµ Ð´Ð¾Ð»Ð³Ð¾Ð²ÑÐµÐ¼ÐµÐ½Ð½Ð¾Ð¹ ÑÐ°Ð±Ð¾ÑÑ Ð½Ð° Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸ÑÑ, Ð¾Ð±ÐµÑÐ¿ÐµÑÐ¸Ð²Ð°ÑÑÐ¸Ñ ÑÑÐ°Ð½ÐµÐ½Ð¸Ðµ Ð¸ ÑÑÐ¸Ð»Ð¸Ð·Ð°ÑÐ¸Ñ ÑÐ¾ÑÑÐ¾ÑÐ¾ÑÐ³Ð°Ð½Ð¸ÑÐµÑÐºÐ¸Ñ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ð¹, Ð½Ð° Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ ÑÐµÑÐ¼ÐµÐ½ÑÐ° Ð¿Ð°ÑÐ°Ð¾ÐºÑÐ¾Ð½Ð°Ð·Ñ 1 Ð¸ ÑÐ°Ð·Ð²Ð¸ÑÐ¸Ðµ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°Ð½Ð¸Ð¹ Ð¿Ð¸ÑÐµÐ²Ð°ÑÐ¸ÑÐµÐ»ÑÐ½Ð¾Ð¹ ÑÐ¸ÑÑÐµÐ¼Ñ Ð² Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÐ¸ Ð¾Ñ Ð³ÐµÐ½Ð¾ÑÐ¸Ð¿Ð° Ð¿Ð¾ Ð³ÐµÐ½Ñ PON1. ÐÐµÑÐ¾Ð´Ð¾Ð¼ Ð¿Ð¾Ð»Ð¸Ð¼ÐµÑÐ°Ð·Ð½Ð¾Ð¹ ÑÐµÐ¿Ð½Ð¾Ð¹ ÑÐµÐ°ÐºÑÐ¸Ð¸ Ð¸ ÑÐµÑÑÑÐ¸ÐºÑÐ¸Ð¾Ð½Ð½Ð¾Ð³Ð¾ Ð°Ð½Ð°Ð»Ð¸Ð·Ð° Ð±ÑÐ» Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½ Ð³ÐµÐ½Ð¾ÑÐ¸Ð¿ Ð¿Ð¾ Ð²Ð°ÑÐ¸Ð°Ð½ÑÐ°Ð¼ L54M, Q191R, C(-108)T Ð³ÐµÐ½Ð° PON1, Ð¸Ð·Ð¼ÐµÑÐµÐ½Ð° Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ ÑÐµÑÐ¼ÐµÐ½ÑÐ° Ð¿Ð°ÑÐ°Ð¾ÐºÑÐ¾Ð½Ð°Ð·Ñ 1 Ñ ÑÐ°Ð±Ð¾ÑÐ½Ð¸ÐºÐ¾Ð² Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ð¹, Ð¾Ð±ÐµÑÐ¿ÐµÑÐ¸Ð²Ð°ÑÑÐ¸Ñ ÑÑÐ°Ð½ÐµÐ½Ð¸Ðµ Ð¸ ÑÑÐ¸Ð»Ð¸Ð·Ð°ÑÐ¸Ñ ÑÐ¾ÑÑÐ¾ÑÐ¾ÑÐ³Ð°Ð½Ð¸ÑÐµÑÐºÐ¸Ñ ÑÐ¾ÐµÐ´Ð¸Ð½ÐµÐ½Ð¸Ð¹ Ð¸ Ð² ÐºÐ¾Ð½ÑÑÐ¾Ð»ÑÐ½Ð¾Ð¹ Ð³ÑÑÐ¿Ð¿Ðµ. ÐÑÐµ Ð¿Ð¾Ð»ÑÑÐµÐ½Ð½ÑÐµ ÑÐµÐ·ÑÐ»ÑÑÐ°ÑÑ Ð±ÑÐ»Ð¸ ÑÐ²ÐµÐ´ÐµÐ½Ñ Ð² ÑÐ°Ð±Ð»Ð¸ÑÑ Ð¸Ð»Ð¸ Ð³ÑÐ°ÑÐ¸ÐºÐ¸ Ð¸ ÑÑÐ°ÑÐ¸ÑÑÐ¸ÑÐµÑÐºÐ¸ Ð¾Ð±ÑÐ°Ð±Ð¾ÑÐ°Ð½Ñ. ÐÐ°ÑÐµ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ðµ Ð¿Ð¾ÐºÐ°Ð·Ð°Ð»Ð¾, ÑÑÐ¾ Ð² ÑÐµÐ»Ð¾Ð¼ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ PON1 Ð±ÑÐ»Ð° Ð²ÑÑÐµ Ñ ÑÐ°Ð±Ð¾ÑÐ½Ð¸ÐºÐ¾Ð² Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ñ Ð¿Ð¾ ÑÑÐ¸Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¤ÐÐ¡, ÑÐµÐ¼ Ð² ÐºÐ¾Ð½ÑÑÐ¾Ð»ÑÐ½Ð¾Ð¹ Ð³ÑÑÐ¿Ð¿Ðµ. Ð Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÐ¸ Ð¾Ñ Ð³ÐµÐ½Ð¾ÑÐ¸Ð¿Ð° L54M, Ñ ÑÐ°Ð±Ð¾ÑÐ½Ð¸ÐºÐ¾Ð²-Ð½Ð¾ÑÐ¸ÑÐµÐ»ÐµÐ¹ Ð³ÐµÐ½Ð¾ÑÐ¸Ð¿Ð° LL Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ PON1 Ð±ÑÐ»Ð° Ð²ÑÑÐµ, ÑÐµÐ¼ Ñ Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð¸ÑÐµÐ»ÐµÐ¹ ÐºÐ¾Ð½ÑÑÐ¾Ð»ÑÐ½Ð¾Ð¹ Ð³ÑÑÐ¿Ð¿Ñ, ÑÐ²Ð»ÑÑÑÐ¸ÑÑÑ Ð½Ð¾ÑÐ¸ÑÐµÐ»ÑÐ¼Ð¸ Ð´Ð°Ð½Ð½Ð¾Ð³Ð¾ Ð³ÐµÐ½Ð¾ÑÐ¸Ð¿Ð°. Ð Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼Ð¾ÑÑÐ¸ Ð¾Ñ Ð³ÐµÐ½Ð¾ÑÐ¸Ð¿Ð° C(-108)T, Ñ ÑÐ°Ð±Ð¾ÑÐ½Ð¸ÐºÐ¾Ð²-Ð½Ð¾ÑÐ¸ÑÐµÐ»ÐµÐ¹ Ð°Ð»Ð»ÐµÐ»Ñ Ð¡ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ PON1 Ð±ÑÐ»Ð° Ð²ÑÑÐµ, ÑÐµÐ¼ Ñ Ð¿ÑÐµÐ´ÑÑÐ°Ð²Ð¸ÑÐµÐ»ÐµÐ¹ ÐºÐ¾Ð½ÑÑÐ¾Ð»ÑÐ½Ð¾Ð¹ Ð³ÑÑÐ¿Ð¿Ñ, ÑÐ²Ð»ÑÑÑÐ¸ÑÑÑ Ð½Ð¾ÑÐ¸ÑÐµÐ»ÑÐ¼Ð¸ Ð´Ð°Ð½Ð½Ð¾Ð³Ð¾ Ð°Ð»Ð»ÐµÐ»Ñ. Ð¡ÑÐµÐ´Ð¸ ÑÐ°Ð±Ð¾ÑÐ½Ð¸ÐºÐ¾Ð² Ð¿ÑÐµÐ´Ð¿ÑÐ¸ÑÑÐ¸Ð¹ Ð¿Ð¾ ÑÑÐ¸Ð»Ð¸Ð·Ð°ÑÐ¸Ð¸ Ð¤ÐÐ¡, ÑÐ²Ð»ÑÑÑÐ¸ÑÑÑ Ð½Ð¾ÑÐ¸ÑÐµÐ»ÑÐ¼Ð¸ Ð°Ð»Ð»ÐµÐ»Ñ 191R, Ð±Ð¾Ð»ÐµÐµ Ð²ÑÑÐ¾ÐºÐ°Ñ Ð°ÐºÑÐ¸Ð²Ð½Ð¾ÑÑÑ Ð¿Ð°ÑÐ°Ð¾ÐºÑÐ¾Ð½Ð°Ð·Ñ 1 Ð±ÑÐ»Ð° ÑÐ°ÑÐ°ÐºÑÐµÑÐ½Ð° Ð´Ð»Ñ Ð»Ð¸Ñ Ñ Ð¶Ð¸ÑÐ¾Ð²ÑÐ¼ Ð³ÐµÐ¿Ð°ÑÐ¾Ð·Ð¾Ð¼.
description: In this work, we were to study the effect of long-term work with exposure to the toxic OPs on the PON1 activity and the development of diseases of the digestive system depending on the genotype PON1 gene. Polymerase chain reaction and restriction analysis was determined by genotype variants L54M, Q191R, C (-108) T PON1 gene. We measured activity of the enzyme paraoxonase 1 the workers of companies providing storage and disposal of the OPs and control group. All the results were summarized in table or graphic and statistically processed. Our study showed that PON1 activity in workers with exposure to the toxic OPs relative was increased compared to the control group. Differences in serum PON1 activity was shown for the carriers of certain genotypes of the PON1 gene: PON1 serum activity was higher in workers compared to controls only for LL genotype (L54M polymorphism) and C allele ( C(-108)T polymorphism) carriers. Among the workers of companies providing storage and disposal of the OPs, which are carriers of the allele 191R, activity of paraoxonase 1 was increased by people with steatosis.