cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Regional Correlations of Late Pleistocene Climatic Changes Based on Cosmogenic Nuclide Exposure Dating of Moraines in Idaho
Creators: name: Sherard, Cody
Publisher: name: Western Washington University
Year: 2006

description:
Multiple post-last glacial maximum (LGM) moraines occur in the Sawtooth Range of the Rocky Mountains in central Idaho. Although relative ages of the moraines have been studied, few numerical ages exist for these moraine sequences. In this study, the ages of LGM and late glacial (Younger Dryas) moraines in the Redfish Lake drainage of Idaho are constrained with 23 new, cosmogenic, 10Be dates. Results of this study include developing a new chronology for the Redfish Lake late Pleistocene moraines that are consistent with regional morainal ages.

New cosmogenic 10Be data from boulders on Bull Lake moraines at Redfish Lake are consistent with other dates obtained from Bull Lake moraines elsewhere in the Rocky Mountains. Ages of 107 to 206 ka and 238 to 323 ka suggest synchroniety with other Bull Lake glacial advances in the Wind River Range, Tetons, and Yellowstone.

New cosmogenic 10Be data from boulders on terminal moraines in Redfish Lake valley, Idaho, show a LGM at 18.5 ± 0.9 ka to 15.6 ± 0.8 ka, recessional (or minor readvance) moraines deposited between 15.4 ± 0.7 ka and 14.2 ± 0.7 ka; and a Younger Dryas (YD) phase at 11.4-11.7 ± 0.5 ka. Boulders on an LGM moraine at Alturas Lake, Idaho were 10Be dated in order to supplement and test the existing concepts of glaciation there. Ages of 17.2 ± 1.0 ka and 16.8 ± 0.8 ka indicate that this moraine is late Pinedale, not mid-Pinedale as previously suggested by Thackray et al. (2004).

The late Pleistocene ice chronology at Redfish Lake is consistent with the glacial chronology in the Wind River Range, WY (LGM 24 ka to l8 ka; recessional deposits 18 ka to 16 ka and YD 11.5 ka); Yellowstone, WY (LGM advances: 29.5-22.5 ka, and 19.5- 5.5 ka); Wallowa Mountains, OR (two 10Be dated LGM advances: 21.1 ± 0.4 ka and 17.0 ± 0.3 ka, and YD advance: 10.2 ± 0.6 ka); Crowfoot Lake, Canada (YD advance: 11,330 ± 220-10,100 ± 70 14C yrs B.P.); and many other places throughout western North America. This research provides chronological constraints on Pinedale LGM (~18.5 ka) moraines, Pinedale recessional (between 18.5 and 14.2 ka) moraines, and Younger Dryas (~11.4 ka) moraines in the Sawtooth Range of the Rocky Mountains, and assists in determining the areal extent of the late Pleistocene cold period in the Western United States.
Experiencing subtle and overt sexism from the target’s perspective
Creators: name: Stanke, Franziska
name: Stermann, Marie
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Social Psychology
subject: Social and Behavioral Sciences
subject: Psychology
subject: FOS: Psychology

description: In this study, we examine womens experience of subtle and overt sexist situations and explore several factors that may influence perceptions of those situations and the psychological distress they cause. 1) we investigate the perception of subtle and overt sexist situations and how perceived peer norms and societal norms can influence ones own perception of discrimination. 2) we investigate the psychological distress that can be caused by subtle and overt sexist situations and how it is influenced by ones self-concept and use of social support.
Additional file 5 of Human cortical spheroids with a high diversity of innately developing brain cell types
Creators: name: De Kleijn, Kim M. A.
name: Zuure, Wieteke A.
name: Straasheijm, Kirsten R.
name: Martens, Marijn B.
name: Avramut, M. Cristina
name: Koning, Roman I.
name: Martens, Gerard J. M.
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 5: Fig. S5. Modulation of BMP4 concentration tweaks the ratio between the extent of neuroectoderm- and mesoderm development. (A) Representative images of the morphologies and sizes of human cortical spheroids (hCSs) (batch-2), including neuroectoderm-layer formation/neural rosettes (blue arrow heads) at days 1, 12, 23 and 70 following culturing in the presence of 10 μM SB43152 and 0.1, 1, 2.5 or 10 μM dorsomorphin (DM). hCSs cultured in the presence of a high degree of SMAD inhibition (10 μM DM) and with a starting density of 1.25*104 H9 ESCs did not aggregate into spheres. (B) Quantifications of hCS (batch-2) circumferences during days 0 until 70 following culturing with 10 μM SB43152 and 0.1, 1 or 2.5 μM DM. (C) Representative immunocytochemistry whole-spheroid (batch-2) images and mean field-intensity quantifications of MAP2 (neuron) and GFAP (astrocyte) protein expression in day-13 (d13), d23 and d33 hCSs cultured in the presence of 0.1, 1 or 2.5 μM DM. ANOVA with Tukey post hoc comparisons: ** p < 0.01, * p < 0.05. (D) Levels of mRNA expression of the microglial marker TMEM119 in d13, d23 and d33 hCSs (batch-2) following culturing with 10 μM SB43152 and 0.1, 1 or 2.5 μM DM, as determined by qPCR analysis. ANOVA with Tukey post hoc comparisons: ** p < 0.01, * p < 0.05. Each data point in (C) and (D) represents one spheroid. Error bars represent the standard error of the mean.
Additional file 1 of Growth, physiological, and molecular responses of three phaeophyte extracts on salt-stressed pea (Pisum sativum L.) seedlings
Creators: name: Hamouda, Marwa M.
name: Badr, Abdelfattah
name: Ali, Sameh S.
name: Adham, Alia M.
name: Ahmed, Hanan I. Sayed
name: Saad-Allah, Khalil M.
Publisher: name: figshare
Year: 2023
Subjects: subject: Plant Biology
subject: FOS: Biological sciences

description: Additional file 1: Table S1. The presence-absence score of leaf proteins SDS-PAGE profile of pea seedlings under salinity stress treatments and priming with extract of the seaweeds Sargassum vulgare (S) Colpomenia sinuosa (C) and Pandia pavonica (P), and their combinations. Band type*: Polymorphic (P), Monomorphic (M) and Unique (U). Table S2. ISSR fingerprinting score produced by the DNA of 21-days-old pea leaves using the seven primers given in Table 1, grown under 50 ,100, and 150 mM NaCl in combination with marine brown seaweeds (Sargassum vulgare (S), Colpomenia sinuosa (C), and Pandia pavonica (P)).
Römer und Alamannen – Neue Dauerausstellung im Stadtmuseum Bad Krozingen
Creators: name: Bücker, Christel
name: Hoeper, Michael
Publisher: name: Archäologische Nachrichten aus Baden
Year: 2018

description: -
description: Archäologische Nachrichten aus Baden, Bd. 80/81 (2010): Archäologische Nachrichten aus Baden
Additional file 7 of Positive feedback between lncRNA FLVCR1-AS1 and KLF10 may inhibit pancreatic cancer progression via the PTEN/AKT pathway
Creators: name: Lin, Jiewei
name: Zhai, Shuyu
name: Zou, Siyi
name: Xu, Zhiwei
name: Zhang, Jun
name: Jiang, Lingxi
name: Deng, Xiaxing
name: Chen, Hao
name: Peng, Chenghong
name: Zhang, Jiaqiang
name: Shen, Baiyong
Publisher: name: figshare
Year: 2021
Subjects: Biophysics
Biochemistry
Medicine
Cell Biology
Molecular Biology
Biological Sciences not elsewhere classified
Developmental Biology
Cancer

description: Additional file 7: Table S4. Antibodies used for western blotting.
title: Embraceable Joe: Notes on Joe Brainard’s Art
Creators: name: Drąg, Wojciech
Publisher: name: Electronic Book Review
Year: 2020

description: A comprehensive summary of a career that, unlike those of Warhol, Lichtenstein, Katz or most other contemporaries, lets us recognize Joe Brainard as an antecedent of our current, dispersed and all-embracing digital arts practices. As Nathan Kernan argues in 2019, our multimodal online habitus “looks more and more like a Joe Brainard world.” Wojciech Drąg takes us further into Brainard's lifelong refusal of artistic grandeur. An aesthetic of visual attention that purifies objects and pieces of writing where Brainard wonders if he can ¨get by without saying anything.¨
An hydroxytyrosol enriched extract from olive mill wastewaters exerts antioxidant activity and antimicrobial activity on Pseudomonas savastanoi pv. savastanoi and Agrobacterium tumefaciens
Creators: name: Pannucci, Elisa
name: Caracciolo, Rocco
name: Romani, Annalisa
name: Cacciola, Francesco
name: Dugo, Paola
name: Bernini, Roberta
name: Varvaro, Leonardo
name: Santi, Luca
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Cancer

description: An hydroxytyrosol (HTyr) enriched extract (HTE), obtained from olive mill wastewaters (OMWW) through an eco-friendly, patented process was tested on two olive tree pathogens, Pseudomonas savastanoi pv. savastanoi (Pss) and Agrobacterium tumefaciens (At). Pss, in particular, is a feared treat for olive tree cultivation being the etiological agent of the olive knot disease responsible of severe production losses. Chemical characterization allowed to identify and quantify HTyr as the main constituent along with other low molecular weight phenols. HTE has proven potent antioxidant activity and significant antimicrobial activity against Pss and At in vitro, in both cases higher than hydroxytyrosol alone, suggesting an important role also of the minor phenolic components, which act synergistically with HTyr. Alternatives to the molecules currently present on the market are needed, but only the use of standardized extraction technologies would allow to conduct solid field studies and enable this circular approach to find a real application in the olive groves.
Additional file 1 of IFN-γ blockade after genetic inhibition of PD-1 aggravates skeletal muscle damage and impairs skeletal muscle regeneration
Creators: name: Zhuang, Shuzhao
name: Russell, Aaron
name: Guo, Yifan
name: Xu, Yingying
name: Xiao, Weihua
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Genetics
subject: Physiology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1. Original images of western blotting.
State of the Unions
Creators: name: Caluwaerts, Didier
name: Bernaerts, Kamil
Publisher: name: Open Science Framework
Year: 2023
Subjects: subject: Social and Behavioral Sciences
subject: Comparative Politics
subject: Political Science
subject: FOS: Political science

description: This project consists of one episode of data collection consisting of a survey experiment. The main aim of the project is to disentangle the effects of various forms of polarisation on democracy in Belgium and the UK. It will result in multiple papers.
Sabine Faust, Fulcra: figürlicher und ornamentaler Schmuck an antiken Betten
Creators: name: Barr-Sharrar, Beryl
Publisher: name: Bonner Jahrbücher
Year: 2018

description: Rezension zu: Sabine Faust, Fulcra: figürlicher und ornamentaler Schmuck an antiken Betten. Mitteilungen des Deutschen Archäologischen Instituts, Römische Abteilung, Ergänzungsheft 30. Verlag Philipp von Zabern, Mainz 1989. 248 Seiten, 11 Abbildungen im Text, 80 Tafeln, 2 Tabellen, 2 Karten, 1 Beilage.
description: Bonner Jahrbücher, Bd. 194.1994: Bonner Jahrbücher
Collective Chemotactic Dynamics in the Presence of Self-Generated Fluid Flows
Creators: name: Lushi, Enkeleida
name: Goldstein, Raymond E.
name: Shelley, Michael J.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Biological Physics (physics.bio-ph)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: In micro-swimmer suspensions locomotion necessarily generates fluid motion, and it is known that such flows can lead to collective behavior from unbiased swimming. We examine the complementary problem of how chemotaxis is affected by self-generated flows. A kinetic theory coupling run-and-tumble chemotaxis to the flows of collective swimming shows separate branches of chemotactic and hydrodynamic instabilities for isotropic suspensions, the first driving aggregation, the second producing increased orientational order in suspensions of "pushers" and maximal disorder in suspensions of "pullers". Nonlinear simulations show that hydrodynamic interactions can limit and modify chemotactically-driven aggregation dynamics. In puller suspensions the dynamics form aggregates that are mutually-repelling due to the non-trivial flows. In pusher suspensions chemotactic aggregation can lead to destabilizing flows that fragment the regions of aggregation.
description: 4 pages
Comparative study on the chemical composition and biological activities of the essential oils of three Lagochilus species collected from Uzbekistan
Creators: name: Akramov, Davlat Kh.
name: Zengin, Gokhan
name: Kang, Sun Chul
name: Tojibaev, Komiljon Sh.
name: Mahomoodally, Mohamad Fawzi
name: Azimova, Shahnoz S.
name: Mamadalieva, Nilufar Z.
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: Lagochilus species are mainly distributed in Central Asia and widely used in folk medicine as a sedative and haemostatic. The present investigation reports on the extraction by hydrodistillation and the chemical composition of three Lagochilus species (L. gypsaceus, L. inebrians and L. setulosus) essential oils from Uzbekistan. The chemical composition of these essential oils was determined by GC-MS. The results showed that the studied essential oils are made up mainly of linalool (11.97%), β-ionone (11.75%), trans-chrysanthenyl acetate (7.15%), α-terpineol (7.40%) for L. gypsaceus; trans-chrysanthenyl acetate (9.40%), eugenol (7.01%), trans-verbenol (3.85%), bicyclo[3.1.1]hept-3-en-2-one (3.76%), pinocarvone (3.43%) for L. inebrians; and finally 2,4-bis(1,1-dimethylethyl)phenol (19.78%), bicyclo[3.1.1]hept-2-en-4-ol (5.43%), hexadecanoic acid (5.39%), limonene (5.19%), 2-hexenal (5.03%) for L. setulosus. The best antioxidant and tyrosinase inhibitory activity was observed for the essential oil of L. inebrians. However, L. setulosus essential oil exhibited the strongest inhibitory effect against amylase.
Additional file 4 of Human cortical spheroids with a high diversity of innately developing brain cell types
Creators: name: De Kleijn, Kim M. A.
name: Zuure, Wieteke A.
name: Straasheijm, Kirsten R.
name: Martens, Marijn B.
name: Avramut, M. Cristina
name: Koning, Roman I.
name: Martens, Gerard J. M.
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 4: Fig. S4. Complete omission of SMAD inhibition (absence of dorsomorphin and SB43152 in the culture medium) results in mitigated growth of neuroectoderm-derived neurons and astrocytes. (A) Representative images of whole-spheroid signal scans of the neuronal marker MAP2, the astrocyte marker GFAP and the oligodendrocyte marker O1 in day-17 (d17), d33 and d73 human cortical spheroids (hCSs) (batch-11) grown with dorsomorphin and SB-431542 (+ SMAD inhibition) or without dorsomorphin and SB-431542 (- SMAD inhibition) in the culture medium. (B) Quantifications of the mean MAP2-, GFAP- and O1-signal intensities per field in d17, d33 and d73 hCSs (batch-11) grown with or without SMAD inhibition. One-way ANOVA per time point for -SMAD vs +SMAD: * p < 0.05. Each data point represents the level of mRNA expression in one spheroid. Error bars represent the standard error of the mean.
Additional file 3 of Human cortical spheroids with a high diversity of innately developing brain cell types
Creators: name: De Kleijn, Kim M. A.
name: Zuure, Wieteke A.
name: Straasheijm, Kirsten R.
name: Martens, Marijn B.
name: Avramut, M. Cristina
name: Koning, Roman I.
name: Martens, Gerard J. M.
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 3: Fig. S3. Low variability in the number of P2RY12-positive microglial cells among independent human cortical spheroid (hCS) batches and in hCSs grown with various start-cell densities. (A) Left: Representative immunocytochemistry (ICC) images of whole-spheroid signal scans of the microglia marker P2RY12 in five independently grown batches of day-150 (d150) hCSs. Microglia often developed in patch-like structures within the hCSs. Right: Quantifications of the mean P2RY12 signal intensities per field in five independently grown d150 hCS batches. ANOVA with Tukey post hoc comparisons: ** p < 0.01, * p < 0.05. (B) Left: Representative ICC images of whole-spheroid P2RY12 signal scans of d150 hCSs grown with various start H9 human embryonic stem cell (ESC) densities. Right: Quantifications of the mean P2RY12 signal intensities per field in d150 hCSs grown with 1.0*104, 2.0*104 or 4.0*104 start H9 ECSs. ANOVA with Tukey post hoc comparisons: ns, not significant. Each data point in (A) and (B) represents the level of mRNA expression in one spheroid. Error bars represent the standard error of the mean.
Inhibition of nitric oxide production by clerodane diterpenoids from leaves and stems of Croton poomae Esser
Creators: name: Somteds, Apisara
name: Tantapakul, Cholpisut
name: Kanokmedhakul, Kwanjai
name: Laphookhieo, Surat
name: Phukhatmuen, Piyaporn
name: Kanokmedhakul, Somdej
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Space Science
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: Chromatographic separation of crude extracts from the leaves and stems of Croton poomae Esser led to the isolation of two new clerodane diterpenes crotonolide K (1) and furocrotinsulolide A acetate (2) and six known clerodane diterpenes (3–8), together with twelve known compounds (9–20). Their structures were established from spectroscopic analysis. The clerodane diterpenoids 1–8 were evaluated for inhibition of nitric oxide (NO) production in LPS-activated RAW 264.7 macrophages. Compounds 1, 2, 5, 7 and 8 showed potent inhibitory effects, with IC50 values ranging from 32.19 to 48.85 μM, which is better than both the standard drugs indomethacin (154.5 μM) and dexamethasone (56.28 μM).
A new antibacterial tirucallane from Walsura trichostemon roots
Creators: name: Suchaichit, Nattawut
name: Kanokmedhakul, Kwanjai
name: Promgool, Trinop
name: Moosophon, Panawan
name: Chompoosor, Apiwat
name: Suchaichit, Natcha P
name: Kanokmedhakul, Somdej
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified

description: Phytochemical investigation of the roots of Walsura trichostemon, a Thai medicinal plant, provided a new tirucallane, 3-epimesendanin S 12-acetate (1), together with four known compounds, 3-epimesendanin S (2), meliasenin G (3), β-sitosterol (4) and β-sitosterol glucoside (5). Their structures were characterized by intensive spectroscopy including 1 D and 2 D NMR, UV, IR and MS spectrometric analysis. The isolated compounds were evaluated for antibacterial and acetylcholinesterase inhibitory activities. Compounds 1–2 showed antibacterial activity against Bacillus cereus and Bacillus subtilis with MIC values ranging from 16–128 μg/mL. In addition, compound 3 was active against Pseudomonas aeruginosa and Escherichia coli with MIC values of 64 and 128 μg/mL, respectively.
title: A country that loses control of its past loses control of its future
title: The Role of Architecture Heritage Maintaining Culture Identity Post Natural Disasters Kathmandu, Nepal as a case study
titleType: Subtitle
Creators: name: Wright, Katie
Publisher: name: Oxford Brookes University
Year: 2020

description: As one of the most seismically dangerous regions in the world, it is remarkable that Kathmandu maintains to have an abundance of architectural heritage. However, as a result of the 2015 earthquake, many of the esteemed world heritage status buildings and temples were damaged, several beyond repair. Many people share the opinion that the destruction caused by natural disasters provides an opportunity in underdeveloped countries to ‘build back better’ with improved facilities, to ensure an enhanced quality of life. Whilst this strategy is most commonly enforced on vernacular heritage it has also been applied to the significant historical and cultural buildings. Whilst this can still have authentic significance and value to the community, opposing opinions such as Oliver-Smith’s, would suggest that rebuilding in a more modern vernacular could ‘endanger the connection that people have with their built environment, violating cultural norms of space and place, inhibiting the re-weaving of social networks and delaying or stopping the re-emergence of community identity’. Cultural heritage preservation is important to protect a society’s economically valuable material assets, preserve traditions, history and the environment, and a sense of continuity and identity. Historical buildings and heritage function as a collective memory and ‘Without memory, a sense of self, identity, culture and heritage is lost’, it helps give individuals a sense of belonging in time and place. Natural disasters can put architectural heritage at great risk both directly, from the disaster itself such as ground shaking caused by an earthquake, and secondary hazards such as fire caused by a damaged electricity mains. Humans actions such as building repairs can also be a threat to the heritage. This research aims to evaluate the importance of heritage to the local economy and its social significance, and to conclude whether it is best to repair or rebuild heritage or to memorialise or document it and build something new.
On quantum plasma: a plea for a common sense
Creators: name: Vranjes, J.
name: Pandey, B. P.
name: Poedts, S.
Publisher: name: arXiv
Year: 2012
Subjects: subject: Plasma Physics (physics.plasm-ph)
subject: FOS: Physical sciences

description: The quantum plasma theory has flourished in the past few years without much regard to the physical validity of the formulation or its connection to any real physical system. It is argued here that there is a very limited physical ground for the application of such a theory.
description: EPL, to be published 2012
Identification of polyphenolic contents, in vitro evaluation of antioxidant and antidiabetic potentials of a polyherbal formulation-Mehani
Creators: name: Venkateswaran, Meenakshi R.
name: Jayabal, Sasidharan
name: Murugesan, Selvakumar
name: Periyasamy, Sureshkumar
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: Diabetes has become a global disease that needs an alternative drug treatment with lesser side effects. The present study was aimed to evaluate the antioxidant and antidiabetic activities of soxhlet and microwave assisted extraction of a polyherbal formulation-Mehani using aqueous, hydroalcoholic and hexane solvents. Preliminary investigation shows that the heavy metal contents were within the permissible limits. Comparative antioxidant studies showed that hydroalocoholic soxhlet (HAS) and microwave (HAM) extracts possessed highest activity as assessed through DPPH assay (93.8 ± 0.04%, 94.85 ± 0.04%), H2O2 assay (88.7 ± 0.9%, 87.2 ± 1.4%), reducing power assay (absorbance-1.61 ± 0.12, 2.08 ± 0.03) and nitric oxide scavenging activity (51.1 ± 0.9%, 56.5 ± 0.18%) at 500 µg/mL concentration. HAS and HAM also exhibited 80.3 ± 1.12% and 85.3 ± 1.86% of α-amylase inhibitory activity and 78.7 ± 0.15% and 80.0 ± 0.63% of glucosidase inhibitory activity. HPLC analysis in both the extracts reveals the presence of eight polyphenols with gallic acid being the predominant compound; these might be responsible for the highest activities.
Time delay matrix at the spectrum edge and the minimal chaotic cavities
Creators: name: Abbout, Adel
Publisher: name: arXiv
Year: 2012
Subjects: subject: Disordered Systems and Neural Networks (cond-mat.dis-nn)
subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Statistical Mechanics (cond-mat.stat-mech)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: Using the concept of minimal chaotic cavities, we give the distribution of the proper delay times of $Q=-i\hbar S^\dagger \frac{\partial S}{\partial E}$ at the spectrum edge with a scattering matrix $S$ belonging to circular ensembles CE. The three classes of symmetry ($β=1$, 2 and 4) will be analyzed to show how it differs from the distribution obtained in the bulk of the spectrum. In this new class of universality at the spectrum edge, more attention will be given to the Wigner time $τ_w=tr(Q)$ and its distribution will be given analytically in the case of 2 modes scattering. The results will be presented exactly at all the Fermi energies without any approximation. All this will be tested numerically with an excellent precision.
description: 7 pages, 4 figures
Evidence of growing spatial correlations during the aging of glassy glycerol
Creators: name: Brun, C.
name: Ladieu, F.
name: L'Hôte
name: Biroli, G.
name: Bouchaud, Jean-Philippe
Publisher: name: arXiv
Year: 2012
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: We have measured, as a function of the age $t_a$, the aging of the nonlinear dielectric susceptibility $χ_3$ of glycerol below the glass transition. Whereas the linear susceptibility can be accurately accounted for in terms of an age dependent relaxation time $τ_α(t_a)$, this scaling breaks down for $χ_3$, suggesting an increase of the amplitude of $χ_3$. This is a strong indication that the number $N_{corr}$ of molecules involved in relaxation events increases with $t_a$. For $T=0.96 \times T_g$, we find that $N_{corr}$ increases by $\sim 10%$ when $t_a$ varies from $1\mathrm{ks}$ to $100\mathrm{ks}$. This sheds new light on the relation between length scales and time scales in glasses.
description: Accepted in Physical Review Letters
Additional file 2 of Human cortical spheroids with a high diversity of innately developing brain cell types
Creators: name: De Kleijn, Kim M. A.
name: Zuure, Wieteke A.
name: Straasheijm, Kirsten R.
name: Martens, Marijn B.
name: Avramut, M. Cristina
name: Koning, Roman I.
name: Martens, Gerard J. M.
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Pharmacology
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Additional file 2: Fig. S2. Ultrastructural transmission electron microscopy (TEM) analysis of early-stage (day-39, d39) and late-stage (d150) human cortical spheroids (hCSs) reveals multiple neuroectoderm-derived and mesoderm-derived cell types. (A) Left: Synapse formation in d39 hCS (yellow arrow head: synaptic vesicles). Right: Mature synapses (S) with vesicles (V) in d150 hCS (red arrow heads: dense core vesicles). (B) Overview images of d39 and d150 hCSs showing differences in cell density, length of outgrowths and number of cell contacts. Representative images of (C) astrocytes, (D) oligodendrocyte precursor cells (encircled in right image), (E) mature oligodendrocytes, (F) microglia cells and (G) endothelial cells in d150 hCSs. (H) Levels of mRNA expression of the T-cell/neuronal marker CRTAM, the B-cell markers CD80 and MS4A1, the natural killer cell marker FCGR3A, the leukocyte marker SELL and the dendritic cell marker CD209 in H9 human embryonic stem cells (ESCs) and d150 hCSs, as determined by quantitative PCR (qPCR) analysis. Independent samples T-test: * p < 0.05. Error bars represent the standard error of the mean. Each data point represents the level of mRNA expression in one spheroid. (I) Muscle tissue (‘Mus’) observed occasionally in d150 hCS. (J) Cartilage tissue (‘Cart’) observed occasionally in d150 hCS.
Neisseria gonorrhoeae Aggregation Reduces Its Ceftriaxone Susceptibility
Creators: name: Wang, Liang-Chun
name: Litwin, Madeline
name: Sahiholnasab, Zahraossadat
name: Song, Wenxia
name: Stein, Daniel C.
Publisher: name: MDPI
Year: 2018
Subjects: gonorrhea
antibiotic resistance
increased susceptibility
biofilm
treatment failure
recurrence

description: Antibiotic resistance in Neisseria gonorrhoeae (GC) has become an emerging threat worldwide and heightens the need for monitoring treatment failures. N. gonorrhoeae, a gram-negative bacterium responsible for gonorrhea, infects humans exclusively and can form aggregates during infection. While minimal inhibitory concentration (MIC) tests are often used for determining antibiotic resistance development and treatment, the knowledge of the true MIC in individual patients and how it relates to this laboratory measure is not known. We examined the effect of aggregation on GC antibiotic susceptibility and the relationship between bacterial aggregate size and their antibiotic susceptibility. Aggregated GC have a higher survival rate when treated with ceftriaxone than non-aggregated GC, with bacteria in the core of the aggregates surviving the treatment. GC lacking opacity-associated protein or pili, or expressing a truncated lipooligosaccharide, three surface molecules that mediate GC-GC interactions, reduce both aggregation and ceftriaxone survival. This study demonstrates that the aggregation of N. gonorrhoeae can reduce the susceptibility to antibiotics, and suggests that antibiotic utilization can select for GC surface molecules that promote aggregation which in turn drive pathogen evolution. Inhibiting aggregation may be a potential way of increasing the efficacy of ceftriaxone treatment, consequently reducing treatment failure.
title: How do same-sex hook-up applications impact users’ construction of self and sexual identity?
Creators: name: Winckles, Luke
Publisher: name: Oxford Brookes University
Year: 2020

description: Research into sex and love has demonstrated a clear heteronormative bias, where any behaviours that do not conform to heterosexual norms are deemed ‘deficient’. Perceiving oneself as non-normative has driven people to hide their sexual identity and behaviours. Consequently, the use of hook-up applications such as Grindr have become a fundamental aspect of the gay community, allowing for private sexual liaisons. The current research explores the psychological impact these platforms have on a person’s self and sexual identity by examining the ways in which Grindr is used and the ways the users manage the risks of casual sex. Eight participants (aged 19-37) were interviewed about their experiences of consensual same-sex hook-ups initiated online. Thematic analysis of interviews revealed Grindr usage to have conflicting impacts on self-esteem, elevating it but also reducing it and even contributing to unhealthy addiction to the app. Users constructed a separate ‘sexual’ identity when online, exaggerating desirable aspects of the self. Participants were aware of the risks of unprotected anal sex, but many took that risk to increase pleasure and to feel sexually liberated. The findings can inform the evaluation of existing sexual health interventions and direct future research to explore users’ rationalisations of engaging in high- risk sexual behaviours.
On a Stochastic Leray-α model of Euler equations
Creators: name: Barbato, David
name: Bessaih, Hakima
name: Ferrario, Benedetta
Publisher: name: arXiv
Year: 2012
Subjects: subject: Probability (math.PR)
subject: FOS: Mathematics
subject: 35Q31, 60H15, 35Q35

description: We deal with the 3D inviscid Leray-α model. The well posedness for this problem is not known; by adding a random perturbation we prove that there exists a unique (in law) global solution. The random forcing term formally preserves conservation of energy. The result holds for initial velocity of finite energy and the solution has finite energy a.s.. These results are easily extended to the 2D case.
description: 25 pages; a reference updated;few comments added
Additional file 1 of Insulin-like growth factor-1 receptor controls the function of CNS-resident macrophages and their contribution to neuroinflammation
Creators: name: Ivan, Daniela C.
name: Berve, Kristina Carolin
name: Walthert, Sabrina
name: Monaco, Gianni
name: Borst, Katharina
name: Bouillet, Elisa
name: Ferreira, Filipa
name: Lee, Henry
name: Steudler, Jasmin
name: Buch, Thorsten
name: Prinz, Marco
name: Engelhardt, Britta
name: Locatelli, Giuseppe
Publisher: name: figshare
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: Additional file 1. Morphological characterization of CNS-resident myeloid cells following ablation of IGF-1R.To assess the morphology of CNS resident microglia (brain and spinal cord) and leptomeningeal BAMs in IGF-1RKO-tdTomato (n=4 mice) compared to IGF-1RWT-tdTomato (n=4 mice), we performed Sholl analysis, skeletal analysis and fractal-lacunarity analysis (see methods for more details). The parameters obtained from these 3 morphological analyses were grouped into 4 categories indicating cell size (comprising quantification of soma size, cell density, critical value defined as distance from soma where maximum number of branches occurred), cell shape/elongation (characterized by span ratio and circularity), cell complexity (quantification of cell lacunarity and maximum cell span across a convex hull) and cell ramification (illustrated through summed branch length/cell, maximum branch length/ cell, maximum intersections/cell, number of endpoints/cell (measurement of cell contact with environment), number of junctions/ cell). Number of cells analysed: Brain Microglia: IGF-1RKO-tdTomato (n=84), IGF-1RWT-tdTomato (n=71); Spinal Cord Microglia: IGF-1RKO-tdTomato (n=75) IGF-1RWT-tdTomato (n=66); Leptomeningeal BAMs: IGF-1RKO-tdTomato (n=78) IGF-1RWT-tdTomato (n=91). All values are presented as mean ± SEM. Statistical analysis was performed by using unpaired t test with Welch’s correction for normally distributed data or Mann-Whitney U test for non-normally distributed data. Asterisks indicate significant differences (∗p < 0.05, ∗∗p < 0.01 and ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001).
Chemical constituents and their biological activities from the roots of diospyros filipendula
Creators: name: Wisetsai, Awat
name: Schevenels, Florian T.
name: Lekphrom, Ratsami
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: 80699 Information Systems not elsewhere classified
subject: FOS: Computer and information sciences
subject: Inorganic Chemistry

description: Phytochemical investigation of Diospyros filipendula (Ebenaceae) resulted in the isolation of eighteen compounds. Their structures were identified by analysis of mass spectrometric and spectroscopic (IR, 1 D and 2 D NMR) data. We report three benzoic acid derivatives (1-3), one peptide (4), one coumarin (5), three phthalides (6-8), three steroids (9-11) and seven triterpenes (12-18). Nine compounds (1, 4-8, 10, 17 and 18) are reported from the Ebenaceae family for the first time while the other nine are new to the species D. filipendula. Compounds 7, 17 and 18 showed low to moderate cytotoxicity against NCI-H187 and Vero cell lines while compound 18 showed moderate cytotoxicity against KB cell line. In addition, compounds 17 and 18 showed moderate to significant antimalarial activity against Plasmodium falciparum.
Additional file 2 of Insulin-like growth factor-1 receptor controls the function of CNS-resident macrophages and their contribution to neuroinflammation
Creators: name: Ivan, Daniela C.
name: Berve, Kristina Carolin
name: Walthert, Sabrina
name: Monaco, Gianni
name: Borst, Katharina
name: Bouillet, Elisa
name: Ferreira, Filipa
name: Lee, Henry
name: Steudler, Jasmin
name: Buch, Thorsten
name: Prinz, Marco
name: Engelhardt, Britta
name: Locatelli, Giuseppe
Publisher: name: figshare
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: Additional file 2. Transcriptomic changes in microglia and BAMs upon IGF-1R deletion. A) Sorting strategy of microglia (CD45+CD11b+P2ry12+tdTomato+) and BAMs (CD45+CD11b+P2ry12-CD206+tdTomato+). Cells were sorted from the brain of IGF-1RKO-tdTomato and IGF-1RWT-tdTomato mice directly into RNA protect buffer. B) Venn diagram showing the concordance of gene expression differences in microglia and BAMs from IGF-1RKO-tdTomato and IGF-1RWT-tdTomato mice C) Functional enrichment analysis of the microglia from IGF-1RKO-tdTomato and IGF-1RWT-tdTomato mice using all pathways from the Gene Ontology database. Left, pathways upregulated in IGF-1RKO-tdTomato mice; right, pathways downregulated in IGF-1RKO-tdTomato mice.
title: Dendrochronology of Seaside Juniper (Juniperus maritima)
Creators: name: Gleaves, Dustin
Publisher: name: Western Washington University
Year: 2018

description:
Seaside juniper (Juniperus maritima) is a recently discovered tree species endemic to the Salish Sea region and is an as yet unutilized dendrochronological resource. This study reports the first dendrochronological investigation of the species. We sought to determine if Seaside junipers are capable of crossdating, a requirement for consideration as a dendrochronology study species, and to identify correlations between instrumental climate records and radial growth to determine climate-growth response. We collected tree core samples from Seaside juniper in five sites throughout the San Juan Islands and nearby mainland. Samples collected from one of five sites successfully crossdated. Bootstrapped correlation function analysis found the dominant growth-limiting factor of Seaside junipers is growing season minimum temperatures in the prior year (r = 0.547) and in the current year (r = 0.524), potentially indicating a common growth-limiting factor of either temperature or solar irradiance. Understanding this climate-growth relationship will aid in development of a conservation strategy for this rare and endemic species.
Triterpenes from Archidendron clypearia (Jack) I.C.N. with anti-β-amyloid aggregation activity
Creators: name: Wang, Yu-Xi
name: Duan, Zhi-Kang
name: Chang, Ye
name: Yan, Zhi-Yang
name: Wang, Xiao-Bo
name: Huang, Xiao-Xiao
name: Song, Shao-Jiang
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biophysics
subject: Biochemistry
subject: Pharmacology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Inorganic Chemistry

description: A new triterpene as well as five known compounds were isolated from the twigs and leaves of Archidendron clypearia (Jack) I.C.N. Their structures were established by comprehensive spectroscopic analyses including 1D, 2D NMR and HRESIMS data. The ability of all isolated compounds to inhibit β-amyloid aggregation was investigated by a ThT-based fluorometric assay. Among them, compounds 3 (67.8%) and 6 (77.7%) exhibited higher inhibitory activity than the positive (48.0%). In addition, molecular dynamics and molecular docking have been utilized to predict the detailed binding interaction between ligands and Aβ1-42.
Additional file 3 of Insulin-like growth factor-1 receptor controls the function of CNS-resident macrophages and their contribution to neuroinflammation
Creators: name: Ivan, Daniela C.
name: Berve, Kristina Carolin
name: Walthert, Sabrina
name: Monaco, Gianni
name: Borst, Katharina
name: Bouillet, Elisa
name: Ferreira, Filipa
name: Lee, Henry
name: Steudler, Jasmin
name: Buch, Thorsten
name: Prinz, Marco
name: Engelhardt, Britta
name: Locatelli, Giuseppe
Publisher: name: figshare
Year: 2023
Subjects: subject: Biophysics
subject: Biochemistry
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Physiology
subject: Immunology
subject: FOS: Clinical medicine
subject: Developmental Biology
subject: Cancer

description: Additional file 3. Flow cytometry characterization of CNS-myeloid cell number and phenotype at the symptomatic peak of EAE. A) Gating Strategy for analysis of CNS resident myeloid cells isolated from brain and spinal cords including leptomeninges of IGF-1RKO-tdTomato and IGF-1RWT-tdTomato mice at EAE peak (clinical manifestation: hind leg paralysis). Cells were identified based on their size and granularity, using the forward versus side scatter gating (FSC vs SSC). Following single cell gating (FSC-H vs FSC-A) and selection of alive cells (live-dead staining), we gated for CD45 vs CD11b expression and analyzed two distinct cell populations: CD45highCD11b+ cells and CD45intermediateCD11b+ cells. Within the CD45highCD11b+ cell population, we further gated on Tomato positivity, thus identifying CNS-resident CD45highCD11b+Tomato+ BAMs (C) and CD45highCD11b+Tomatoneg cells illustrating CNS infiltrating blood-derived myeloid cells. The latter population was further gated for Ly6G vs Ly6C positivity and CD45highCD11b+TomatonegLy6GnegLy6C+ population representing CNS infiltrating monocyte-derived macrophages (D) was selected for the final analysis. CNS resident microglial cell population was identified based on CD45intermediateCD11b+Tomato+ expression (B). Representative histograms of marker expression profiles of MHCII, CD44, CD206 on respective myeloid cell populations analysed. We display the absolute number of CNS resident microglial cells (D), BAMs (E) and CNS-infiltrating monocyte-derived macrophages (C) in IGF-1RKO-tdTomato (n=4) and IGF-1RWT-tdTomato (n=4) mice at EAE peak and relative expression (mean fluorescence intensity of sample relative to isotype control staining) or percentage of positive cells of MHC-II, CD206, CD44 molecules. No statistically significant differences were observed in either of the parameters checked within the three populations of cells investigated between in IGF-1RKO-tdTomato and IGF-1RWT-tdTomato mice. All values are presented as mean ± SEM. Statistical analysis was performed by using unpaired t test with Welch`s correction.
Additional file 1 of BG2: Bayesian variable selection in generalized linear mixed models with nonlocal priors for non-Gaussian GWAS data
Creators: name: Xu, Shuangshuang
name: Williams, Jacob
name: Ferreira, Marco A. R.
Publisher: name: figshare
Year: 2023
Subjects: subject: Statistics
subject: FOS: Mathematics

description: Additional file 1. Supplementary Material for BG2: Bayesian variable selection in generalized linear mixed models with nonlocal priors for non-Gaussian GWAS data.
Quantum Cosmology: Effective Theory
Creators: name: Bojowald, Martin
Publisher: name: arXiv
Year: 2012
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Quantum cosmology has traditionally been studied at the level of symmetry-reduced minisuperspace models, analyzing the behavior of wave functions. However, in the absence of a complete full setting of quantum gravity and detailed knowledge of specific properties of quantum states, it remained difficult to make testable predictions. For quantum cosmology to be part of empirical science, it must allow for a systematic framework in which corrections to well-tested classical equations can be derived, with any ambiguities and ignorance sufficiently parameterized. As in particle and condensed-matter physics, a successful viewpoint is one of effective theories, adapted to specific issues one encounters in quantum cosmology. This review presents such an effective framework of quantum cosmology, taking into account, among other things, space-time structures, covariance, the problem of time and the anomaly issue.
description: 75 pages, 3 figures, Invited Topical Review