Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals
Creators: name: Winkler, Thomas W.
name: Rasheed, Humaira
name: Teumer, Alexander
name: Gorski, Mathias
name: Rowan, Bryce X.
name: Stanzick, Kira J.
name: Thomas, Laurent F.
name: Tin, Adrienne
name: Hoppmann, Anselm
name: Chu, Audrey Y.
name: Tayo, Bamidele
name: Thio, Chris H. L.
name: Cusi, Daniele
name: Chai, Jin-Fang
name: Sieber, Karsten B.
name: Horn, Katrin
name: Li, Man
name: Scholz, Markus
name: Cocca, Massimiliano
name: Wuttke, Matthias
name: van der Most, Peter J.
name: Yang, Qiong
name: Ghasemi, Sahar
name: Nutile, Teresa
name: Li, Yong
name: Pontali, Giulia
name: Günther, Felix
name: Dehghan, Abbas
name: Correa, Adolfo
name: Parsa, Afshin
name: Feresin, Agnese
name: de Vries, Aiko P. J.
name: Zonderman, Alan B.
name: Smith, Albert V.
name: Oldehinkel, Albertine J.
name: De Grandi, Alessandro
name: Rosenkranz, Alexander R.
name: Franke, Andre
name: Teren, Andrej
name: Metspalu, Andres
name: Hicks, Andrew A.
name: Morris, Andrew P.
name: Tönjes, Anke
name: Morgan, Anna
name: Podgornaia, Anna I.
name: Peters, Annette
name: Körner, Antje
name: Mahajan, Anubha
name: Campbell, Archie
name: Freedman, Barry I.
name: Spedicati, Beatrice
name: Ponte, Belen
name: Schöttker, Ben
name: Brumpton, Ben
name: Banas, Bernhard
name: Krämer, Bernhard K.
name: Jung, Bettina
name: Åsvold, Bjørn Olav
name: Smith, Blair H.
name: Ning, Boting
name: Penninx, Brenda W. J. H.
name: Vanderwerff, Brett R.
name: Psaty, Bruce M.
name: Kammerer, Candace M.
name: Langefeld, Carl D.
name: Hayward, Caroline
name: Spracklen, Cassandra N.
name: Robinson-Cohen, Cassianne
name: Hartman, Catharina A.
name: Lindgren, Cecilia M.
name: Wang, Chaolong
name: Sabanayagam, Charumathi
name: Heng, Chew-Kiat
name: Lanzani, Chiara
name: Khor, Chiea-Chuen
name: Cheng, Ching-Yu
name: Fuchsberger, Christian
name: Gieger, Christian
name: Shaffer, Christian M.
name: Schulz, Christina-Alexandra
name: Willer, Cristen J.
name: Chasman, Daniel I.
name: Gudbjartsson, Daniel F.
name: Ruggiero, Daniela
name: Toniolo, Daniela
name: Czamara, Darina
name: Porteous, David J.
name: Waterworth, Dawn M.
name: Mascalzoni, Deborah
name: Mook-Kanamori, Dennis O.
name: Reilly, Dermot F.
name: Daw, E. Warwick
name: Hofer, Edith
name: Boerwinkle, Eric
name: Salvi, Erika
name: Bottinger, Erwin P.
name: Tai, E-Shyong
name: Catamo, Eulalia
name: Rizzi, Federica
name: Guo, Feng
name: Rivadeneira, Fernando
name: Guilianini, Franco
name: Sveinbjornsson, Gardar
name: Ehret, Georg
name: Waeber, Gerard
name: Biino, Ginevra
name: Girotto, Giorgia
name: Pistis, Giorgio
name: Nadkarni, Girish N.
name: Delgado, Graciela E.
name: Montgomery, Grant W.
name: Snieder, Harold
name: Campbell, Harry
name: White, Harvey D.
name: Gao, He
name: Stringham, Heather M.
name: Schmidt, Helena
name: Li, Hengtong
name: Brenner, Hermann
name: Holm, Hilma
name: Kirsten, Holger
name: Kramer, Holly
name: Rudan, Igor
name: Nolte, Ilja M.
name: Tzoulaki, Ioanna
name: Olafsson, Isleifur
name: Martins, Jade
name: Cook, James P.
name: Wilson, James F.
name: Halbritter, Jan
name: Felix, Janine F.
name: Divers, Jasmin
name: Kooner, Jaspal S.
name: Lee, Jeannette Jen-Mai
name: O’Connell, Jeffrey
name: Rotter, Jerome I.
name: Liu, Jianjun
name: Xu, Jie
name: Thiery, Joachim
name: Ärnlöv, Johan
name: Kuusisto, Johanna
name: Jakobsdottir, Johanna
name: Tremblay, Johanne
name: Chambers, John C.
name: Whitfield, John B.
name: Gaziano, John M.
name: Marten, Jonathan
name: Coresh, Josef
name: Jonas, Jost B.
name: Mychaleckyj, Josyf C.
name: Christensen, Kaare
name: Eckardt, Kai-Uwe
name: Mohlke, Karen L.
name: Endlich, Karlhans
name: Dittrich, Katalin
name: Ryan, Kathleen A.
name: Rice, Kenneth M.
name: Taylor, Kent D.
name: Ho, Kevin
name: Nikus, Kjell
name: Matsuda, Koichi
name: Strauch, Konstantin
name: Miliku, Kozeta
name: Hveem, Kristian
name: Lind, Lars
name: Wallentin, Lars
name: Yerges-Armstrong, Laura M.
name: Raffield, Laura M.
name: Phillips, Lawrence S.
name: Launer, Lenore J.
name: Lyytikäinen, Leo-Pekka
name: Lange, Leslie A.
name: Citterio, Lorena
name: Klaric, Lucija
name: Ikram, M. Arfan
name: Ising, Marcus
name: Kleber, Marcus E.
name: Francescatto, Margherita
name: Concas, Maria Pina
name: Ciullo, Marina
name: Piratsu, Mario
name: Orho-Melander, Marju
name: Laakso, Markku
name: Loeffler, Markus
name: Perola, Markus
name: de Borst, Martin H.
name: Gögele, Martin
name: Bianca, Martina La
name: Lukas, Mary Ann
name: Feitosa, Mary F.
name: Biggs, Mary L.
name: Wojczynski, Mary K.
name: Kavousi, Maryam
name: Kanai, Masahiro
name: Akiyama, Masato
name: Yasuda, Masayuki
name: Nauck, Matthias
name: Waldenberger, Melanie
name: Chee, Miao-Li
name: Chee, Miao-Ling
name: Boehnke, Michael
name: Preuss, Michael H.
name: Stumvoll, Michael
name: Province, Michael A.
name: Evans, Michele K.
name: O’Donoghue, Michelle L.
name: Kubo, Michiaki
name: Kähönen, Mika
name: Kastarinen, Mika
name: Nalls, Mike A.
name: Kuokkanen, Mikko
name: Ghanbari, Mohsen
name: Bochud, Murielle
name: Josyula, Navya Shilpa
name: Martin, Nicholas G.
name: Tan, Nicholas Y. Q.
name: Palmer, Nicholette D.
name: Pirastu, Nicola
name: Schupf, Nicole
name: Verweij, Niek
name: Hutri-Kähönen, Nina
name: Mononen, Nina
name: Bansal, Nisha
name: Devuyst, Olivier
name: Melander, Olle
name: Raitakari, Olli T.
name: Polasek, Ozren
name: Manunta, Paolo
name: Gasparini, Paolo
name: Mishra, Pashupati P.
name: Sulem, Patrick
name: Magnusson, Patrik K. E.
name: Elliott, Paul
name: Ridker, Paul M.
name: Hamet, Pavel
name: Svensson, Per O.
name: Joshi, Peter K.
name: Kovacs, Peter
name: Pramstaller, Peter P.
name: Rossing, Peter
name: Vollenweider, Peter
name: van der Harst, Pim
name: Dorajoo, Rajkumar
name: Sim, Ralene Z. H.
name: Burkhardt, Ralph
name: Tao, Ran
name: Noordam, Raymond
name: Mägi, Reedik
name: Schmidt, Reinhold
name: de Mutsert, Renée
name: Rueedi, Rico
name: van Dam, Rob M.
name: Carroll, Robert J.
name: Gansevoort, Ron T.
name: Loos, Ruth J. F.
name: Felicita, Sala Cinzia
name: Sedaghat, Sanaz
name: Padmanabhan, Sandosh
name: Freitag-Wolf, Sandra
name: Pendergrass, Sarah A.
name: Graham, Sarah E.
name: Gordon, Scott D.
name: Hwang, Shih-Jen
name: Kerr, Shona M.
name: Vaccargiu, Simona
name: Patil, Snehal B.
name: Hallan, Stein
name: Bakker, Stephan J. L.
name: Lim, Su-Chi
name: Lucae, Susanne
name: Vogelezang, Suzanne
name: Bergmann, Sven
name: Corre, Tanguy
name: Ahluwalia, Tarunveer S.
name: Lehtimäki, Terho
name: Boutin, Thibaud S.
name: Meitinger, Thomas
name: Wong, Tien-Yin
name: Bergler, Tobias
name: Rabelink, Ton J.
name: Esko, Tõnu
name: Haller, Toomas
name: Thorsteinsdottir, Unnur
name: Völker, Uwe
name: Foo, Valencia Hui Xian
name: Salomaa, Veikko
name: Vitart, Veronique
name: Giedraitis, Vilmantas
name: Gudnason, Vilmundur
name: Jaddoe, Vincent W. V.
name: Huang, Wei
name: Zhang, Weihua
name: Wei, Wen Bin
name: Kiess, Wieland
name: März, Winfried
name: Koenig, Wolfgang
name: Lieb, Wolfgang
name: Gao, Xin
name: Sim, Xueling
name: Wang, Ya Xing
name: Friedlander, Yechiel
name: Tham, Yih-Chung
name: Kamatani, Yoichiro
name: Okada, Yukinori
name: Milaneschi, Yuri
name: Yu, Zhi
name: Thio, Chris H. L.
name: van der Most, Peter J.
name: de Borst, Martin H.
name: Ho, Kevin
name: Josyula, Navya Shilpa
name: Pendergrass, Sarah A.
name: Rowan, Bryce X.
name: Robinson-Cohen, Cassianne
name: Gaziano, John M.
name: Phillips, Lawrence S.
name: Tao, Ran
name: Hung, Adriana M.
name: Stark, Klaus J.
name: Stefansson, Kari
name: Böger, Carsten A.
name: Hung, Adriana M.
name: Kronenberg, Florian
name: Köttgen, Anna
name: Pattaro, Cristian
name: Heid, Iris M.
Publisher: name: Universität Regensburg
Year: 2022
Subjects: subject: GENOME-WIDE ASSOCIATION; ENVIRONMENT INTERACTION; QUALITY-CONTROL; METAANALYSIS; LOCI; JOINT; EFFICIENT; SMOKING; DISEASE; EXPRESSION;
subject: 610 Medizin

description: A large-scale GWAS provides insight on diabetes-dependent genetic effects on the glomerular filtration rate, a common metric to monitor kidney health in disease. Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (n(DM) = 178,691, n(noDM) = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM.