cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
On some aspects of the discretization of the Suslov problem
Creators: name: Jimenez, Fernando
name: Scheurle, Juergen
Publisher: name: arXiv
Year: 2015
Subjects: subject: Numerical Analysis (math.NA)
subject: Mathematical Physics (math-ph)
subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics
subject: FOS: Physical sciences

description: In this paper we explore the discretization of Euler-Poincaré-Suslov equations on $SO(3)$, i.e. of the Suslov problem. We show that the consistency order corresponding to the unreduced and reduced setups, when the discrete reconstruction equation is given by a Cayley retraction map, are related to each other in a nontrivial way. We give precise conditions under which general and variational integrators generate a discrete flow preserving the constraint distribution. We establish general consistency bounds and illustrate the performance of several discretizations by some plots. Moreover, along the lines of [14] we show that any constraints-preserving discretization may be understood as being generated by the exact evolution map of a time-periodic non-autonomous perturbation of the original continuous-time nonholonomic system.
description: Nonholonomic mechanics, discretization as perturbation, geometric integration, discrete variational calculus, ordinary differential equations, differential algebraic equations, Lie groups and Lie algebras, reduction of mechanical systems with symmetry. Comments are welcome!!
Decoherence limit of quantum systems obeying generalized uncertainty principle: New paradigm for Tsallis thermostatistics
Creators: name: Jizba, Petr
name: Lambiase, Gaetano
name: Luciano, Giuseppe Gaetano
name: Petruzziello, Luciano
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: Entropy
subject: Nonequilibrium statistical mechanics
subject: Quantum cosmology
subject: Relativistic aspects of cosmology
subject: 500 Naturwissenschaften und Mathematik::530 Physik::530 Physik

description: The generalized uncertainty principle (GUP) is a phenomenological model whose purpose is to account for a minimal length scale (e.g., Planck scale or characteristic inverse-mass scale in effective quantum description) in quantum systems. In this paper, we study possible observational effects of GUP systems in their decoherence domain. We first derive coherent states associated to GUP and unveil that in the momentum representation they coincide with Tsallis probability amplitudes, whose nonextensivity parameter q monotonically increases with the GUP deformation parameter β. Second, for β<0 (i.e., q<1), we show that, due to Bekner-Babenko inequality, the GUP is fully equivalent to information-theoretic uncertainty relations based on Tsallis-entropy-power. Finally, we invoke the maximal entropy principle known from estimation theory to reveal connection between the quasiclassical (decoherence) limit of GUP-related quantum theory and nonextensive thermostatistics of Tsallis. This might provide an exciting paradigm in a range of fields from quantum theory to analog gravity. For instance, in some quantum gravity theories, such as conformal gravity, aforementioned quasiclassical regime has relevant observational consequences. We discuss some of the implications.
The POLD3 subunit of DNA polymerase δ can promote translesion synthesis independently of DNA polymerase ζ
Creators: name: Yamada, Kouich
name: Tsurimoto, Toshiki
name: Lehmann, Alan
name: Pommier, Yves
name: Nakamura, Jun
name: Takeda, Shunichi
name: Murai, Junko
name: Nishihara, Kana
name: Hirota, Kouji
name: Guilbaud, Guillaume
name: Kobayashi, Kaori
name: Sale, Julian E.
name: Tsuda, Masataka
name: Yoshikiyo, Kazunori
name: Phillips, Lara G.
name: Narita, Takeo
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2015

description: The replicative DNA polymerase Polδ consists of a catalytic subunit POLD1/p125 and three regulatory subunits POLD2/p50, POLD3/p66 and POLD4/p12. The ortholog of POLD3 in Saccharomyces cerevisiae, Pol32, is required for a significant proportion of spontaneous and UV-induced mutagenesis through its additional role in translesion synthesis (TLS) as a subunit of DNA polymerase ζ. Remarkably, chicken DT40 B lymphocytes deficient in POLD3 are viable and able to replicate undamaged genomic DNA with normal kinetics. Like its counterpart in yeast, POLD3 is required for fully effective TLS, its loss resulting in hypersensitivity to a variety of DNA damaging agents, a diminished ability to maintain replication fork progression after UV irradiation and a significant decrease in abasic site-induced mutagenesis in the immunoglobulin loci. However, these defects appear to be largely independent of Polζ, suggesting that POLD3 makes a significant contribution to TLS independently of Polζ in DT40 cells. Indeed, combining polη, polζ and pold3 mutations results in synthetic lethality. Additionally, we show in vitro that POLD3 promotes extension beyond an abasic by the Polδ holoenzyme suggesting that while POLD3 is not required for normal replication, it may help Polδ to complete abasic site bypass independently of canonical TLS polymerases.
ผลของการใช้ข้าวไรซ์เบอรี่ต่อฤทธิ์การต้านอนุมูลอิสระในผลิตภัณฑ์ข้าวห่อใบบัวแช่เยือกแข็งและการเปลี่ยนแปลงสมบัติทางกายภาพหลังการทำละลาย
Creators: name: สุนัน ปานสาคร
Publisher: name: สถาบันวิจัยและพัฒนา มหาวิทยาลัยเทคโนโลยีราชมงคลธัญบุรี
Year: 2023
Subjects: ข้าวไรซ์เบอรี่
ฤทธิ์การต้านอนุมูลอิสระ
ข้าวห่อใบบัว
แช่เยือกแข็ง
การทำละลาย

description: Journal of Applied Research on Science and Technology (JARST), 22, 1, 1-12
Design and Functional Analysis of Heterobifunctional Multivalent Phage Capsid Inhibitors Blocking the Entry of Influenza Virus
Creators: name: Adam, Lutz
name: Müller, Eva
name: Ludwig, Kai
name: Klenk, Simon
name: Lauster, Daniel
name: Liese, Susanne
name: Herrmann, Andreas
name: Hackenberger, Christian P. R.
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: Conjugate acid-base pairs
subject: Functionalization
subject: Inhibition
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

description: Multiple conjugation of virus-binding ligands to multivalent carriers is a prominent strategy to construct highly affine virus binders for the inhibition of viral entry into host cells. In a previous study, we introduced rationally designed sialic acid conjugates of bacteriophages (Qβ) that match the triangular binding site geometry on hemagglutinin spike proteins of influenza A virions, resulting in effective infection inhibition in vitro and in vivo. In this work, we demonstrate that even partially sialylated Qβ conjugates retain the inhibitory effect despite reduced activity. These observations not only support the importance of trivalent binding events in preserving high affinity, as supported by computational modeling, but also allow us to construct heterobifunctional modalities. Capsids carrying two different sialic acid ligand–linker structures showed higher viral inhibition than their monofunctional counterparts. Furthermore, capsids carrying a fluorescent dye in addition to sialic acid ligands were used to track their interaction with cells. These findings support exploring broader applications as multivalent inhibitors in the future.
(401233) Marie March [Russell]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
2′-O-HYDROXYALKOXYMETHYLRIBIBONUCLEOSIDE AND THEIR INCORPORATION INTO OLIGORIBONUCLEOTIDES
Creators: name: Herdewijn, Piet
name: Bobkov, Georgii V.
name: Rozenski, Jef
name: Fisher, Michael H.
name: Brilliantov, Kyrill V.
name: Van Aerschot, Arthur
name: Juliano, Rudolph L.
name: Mikhailov, Sergey N.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: A simple and efficient method for the preparation of pyrimidine 2′-O-hydroxyethoxymethylribonucleosides and 2′-O-hydmxypropoxymethylribonucleosides has been developed. These modified nucleosides were incorporated into oligoribonucleotides, which were shown to form stable RNA/RNA duplexes. The effect of 2′-O-modification in the antisense and sense strands of small interference RNA was evaluated in multi-drug resistant NIH 3T3 cells.
A Brief Overview of Adaptive Designs for Phase I Cancer Trials
Creators: name: Saxena, Anshul
name: Rubens, Muni
name: Ramamoorthy, Venkataraghavan
name: Zhang, Zhenwei
name: Ahmed, Md Ashfaq
name: McGranaghan, Peter
name: Das, Sankalp
name: Veledar, Emir
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: phase I trial
subject: cancer clinical trial
subject: adaptive design
subject: maximum tolerated dose
subject: dose-limiting toxicity
subject: nonparametric designs
subject: algorithm-based designs
subject: parametric model-based designs
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Phase I studies are used to estimate the dose-toxicity profile of the drugs and to select appropriate doses for successive studies. However, literature on statistical methods used for phase I studies are extensive. The objective of this review is to provide a concise summary of existing and emerging techniques for selecting dosages that are appropriate for phase I cancer trials. Many advanced statistical studies have proposed novel and robust methods for adaptive designs that have shown significant advantages over conventional dose finding methods. An increasing number of phase I cancer trials use adaptive designs, particularly during the early phases of the study. In this review, we described nonparametric and algorithm-based designs such as traditional 3 + 3, accelerated titration, Bayesian algorithm-based design, up-and-down design, and isotonic design. In addition, we also described parametric model-based designs such as continual reassessment method, escalation with overdose control, and Bayesian decision theoretic and optimal design. Ongoing studies have been continuously focusing on improving and refining the existing models as well as developing newer methods. This study would help readers to assimilate core concepts and compare different phase I statistical methods under one banner. Nevertheless, other evolving methods require future reviews.
title: De Man, That Dangerous Supplement
Creators: name: Filipovic, Zlatan
Publisher: name: Goldsmiths, University of London
Year: 2009

description: To ask whether Paul de Man still matters is perhaps to have already answered the question. De Man's work, as J. Hillis Miller writes in a telling irony, "is a violent allergen that provokes fits of coughing, sneezing, and burning eyes, perhaps even worse symptoms, unless it can be neutralized or expelled." There is something inherently resistant in de Man then that goes beyond his wartime journalism. Dust having settled, one must have good reasons today to whip it up and risk another reactive fit. Yet it is precisely this resistance in de Man that will pivot the movement of this thesis, as it sneezes and coughs along the way. Relayed through the allergen of terms like deconstruction, unreadability, rhetoric, it will come to remark a trace of something inappropriable, inhuman in texts, which persistently stalks our attempts to be rid of it. It articulates a crisis in the empire of cognition and a disruption of epistemo-aesthetic ideologies that inform our thinking of the political. The thesis plots a narrative that interrogates the relation between the rhetorical, the inhuman and the political, which in de Man comes to activate a new exigency of reading, constantly overtasking received epistemic regimes that integrate dissention to open a passage for the new ones to emerge. What is consistently traced is the measured emptying out of ontology and psychologism from language and its opening to unmasterable linguistic agencies. This general freeing of latency in structural closures that de Man's reading always teases out not only unsettles their epistemic reliability but also calls for a permanent assault on the authoritative grounding of their legitimacy. What shocks in de Man's work, provoking systemic fits, is a kind of permanent revolution to which his writing is committed.
Dipole moments of charged leptons in the THDM-III with Textures
Creators: name: Arroyo-Ureña, M.
name: Díaz, Enrique
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We study the magnetic and weak magnetic dipole moments of charged leptons in the framework of the Two Higgs Doublet Model type III (THDM-III) with four zero textures. We first analyze the possibility that the discrepancy between the experimental measurements and the theoretical prediction of the muon anomalous magnetic dipole moment ($a_μ$) in the Standard Model (SM) can be explained in the context of the model and then find values for the parameters of the THDM-III: neutral and charged Higgs boson masses ($m_{H}$, $m_{H^{\pm}}$), mixing angles ($α, β$), CP-violating angles $θ_1,\,θ_2$ and an additional parameter arising from the mass matrix ($γ_f$), for which a correspondence between theory and experiment is possible. We use $a_μ^{THDM-III}$ and current low energy processes $K-\bar{K}$ mixing, $B_s^0\toμ\barμ$, $τ\toμμ\barμ$, $μ\to e e \bar e$, $τ\to μγ$, $τ\to eγ$, $μ\to e γ$, $b\to sγ$, $B\to D (D^*) τν$ and the rare higgs decay $h\toτμ$ in order to determine the allowed parameter space of THDM-III and from these we give a prediction for the magnetic and weak magnetic dipole moment of charged leptons, in particular of the $τ$ lepton. The obtained magnetic dipole moment of the $τ$ lepton is of the order of $\mathcal{O}(10^{-8}-10^{-7})$ and the weak magnetic is of the order $\mathcal{O}(10^{-10}-10^{-7})$.
On the chaos game of Iterated Function Systems
Creators: name: Barrientos, Pablo G.
name: Ghane, F. H.
name: Malicet, Dominique
name: Sarizadeh, A.
Publisher: name: arXiv
Year: 2015
Subjects: subject: Dynamical Systems (math.DS)
subject: FOS: Mathematics

description: Every quasi-attractor of an iterated function system (IFS) of continuous functions on a first-countable Hausdorff topological space is renderable by the probabilistic chaos game. By contrast, we prove that the backward minimality is a necessary condition to get the deterministic chaos game. As a consequence, we obtain that an IFS of homeomorphisms of the circle is renderable by the deterministic chaos game if and only if it is forward and backward minimal. This result provides examples of attractors (a forward but no backward minimal IFS on the circle) that are not renderable by the deterministic chaos game. We also prove that every well-fibred quasi-attractor is renderable by the deterministic chaos game as well as quasi-attractors of both, symmetric and non-expansive IFSs.
Time-resolved multivariate pattern analysis of infant EEG data: A practical tutorial
Creators: name: Ashton, Kira
name: Zinszer, Benjamin D.
name: Cichy, Radoslaw M.
name: Nelson, Charles A.
name: Aslin, Richard N.
name: Bayet, Laurie
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: EEG
subject: Infants
subject: MVPA
subject: Decoding
subject: Representations
subject: 100 Philosophie und Psychologie::150 Psychologie::150 Psychologie

description: Time-resolved multivariate pattern analysis (MVPA), a popular technique for analyzing magneto- and electro-encephalography (M/EEG) neuroimaging data, quantifies the extent and time-course by which neural representations support the discrimination of relevant stimuli dimensions. As EEG is widely used for infant neuroimaging, time-resolved MVPA of infant EEG data is a particularly promising tool for infant cognitive neuroscience. MVPA has recently been applied to common infant imaging methods such as EEG and fNIRS. In this tutorial, we provide and describe code to implement time-resolved, within-subject MVPA with infant EEG data. An example implementation of time-resolved MVPA based on linear SVM classification is described, with accompanying code in Matlab and Python. Results from a test dataset indicated that in both infants and adults this method reliably produced above-chance accuracy for classifying stimuli images. Extensions of the classification analysis are presented including both geometric- and accuracy-based representational similarity analysis, implemented in Python. Common choices of implementation are presented and discussed. As the amount of artifact-free EEG data contributed by each participant is lower in studies of infants than in studies of children and adults, we also explore and discuss the impact of varying participant-level inclusion thresholds on resulting MVPA findings in these datasets.
(401232) Jane/Jennie S Forbes
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Supplementary information from Experimental evolution of parasitic host manipulation.
Creators: name: Hafer-Hahmann, Nina
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 60801 Animal Behaviour

description: The supplementary information contains supplementary tables that provide further statistical information, figures showing the pedigree of parasites used in this study (Fig. S1) and a picture of an infected copepod to illustrate traits measured in this study (Fig. S2), and a section providing more detailed information on potential trade-offs between host manipulation and other fitness related parasite traits.
Determination of neutrino mass ordering in future $^{76}$Ge-based neutrinoless double-beta decay experiments
Creators: name: Zhang, Jue
name: Zhou, Shun
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: Motivated by recent intensive experimental efforts on searching for neutrinoless double-beta decays, we perform a detailed analysis of the physics potential of the experiments based on $^{76}\mathrm{Ge}$. Assuming no signals, current and future experiments could place a $90\%$ lower limit on the half life $T^{0ν}_{1/2} \gtrsim 4\times 10^{26}~{\rm yr}$ and $T^{0ν}_{1/2} \gtrsim 7\times 10^{27}~{\rm yr}$, respectively. Then, how to report an evidence for neutrinoless double-beta decays is addressed by following the Bayesian statistical approach. For the first time, we present a quantitative description of experimental power to distinguish between normal and inverted neutrino mass orderings. Taking an exposure of $10^{4}~{\rm kg}\cdot{\rm yr}$ and a background rate of $10^{-4}~{\rm counts}/({\rm keV}\cdot{\rm kg}\cdot{\rm yr})$, we find that a moderate evidence for normal neutrino mass ordering (i.e., with a Bayes factor ${\cal B}$ given by $\ln({\cal B}) \simeq 2.5$ or a probability about $92.3\%$ according to the Jeffreys scale) can be achieved if the true value of effective neutrino mass $m^{}_{ββ}$ turns out to be below $0.01~{\rm eV}$.
description: 16 pages, 7 figures, the Jeffreys scale used, more discussions added, to appear in Phys. Rev. D
Imatinib-Resistant CML Cells Have Low ENT Activity But Maintain Sensitivity to Gemcitabine
Creators: name: Leisewitz, Andrea V.
name: Graves, Lee M.
name: Jones, Shannon Z.
name: Yang, Jing
name: Zimmerman, Eric I.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Philadelphia chromosome-positive chronic myelogenus leukemia (CML) is widely treated with imatinib mesylate (imatinib), a potent inhibitor of the Bcr-Abl tyrosine kinase. However, resistance to this compound remains a concern. Current treatment approaches include combinations of imatinib with nucleoside analogs such as gemcitabine, which requires equilibrative nucleoside transporters (ENTs) for uptake, to overcome this resistance. Here we report that imatinib treatment decreased ENT1-dependent activity and mRNA expression. Although, imatinib-resistant cells showed decreased levels of both ENT1 and ENT2 activity and expression, these cells remained sensitive to gemcitabine, suggesting that nucleoside analogs can be used as adjunctive therapy.
(401231) Frances Davidson [Burgess]
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
When worlds collide: Invader-driven benthic habitat complexity alters predatory impacts of invasive and native predatory fishes
Creators: name: Coughlan, Neil E.
name: Dickey, James W. E.
name: Dick, Jaimie T. A.
name: Médoc, Vincent
name: McCard, Monica
name: Lacroix, Gérard
name: Fiorini, Sarah
name: Millot, Alexis
name: Cuthbert, Ross N.
Publisher: name: Freie Universität Berlin
Year: 2022
Subjects: subject: Aquatic ecosystem
subject: Corbicula fluminea
subject: Functional response
subject: Habitat complexity
subject: Invasive alien species
subject: Neogobius melanostomus
subject: 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie

description: Interactions between multiple invasive alien species (IAS) might increase their ecological impacts, yet relatively few studies have attempted to quantify the effects of facilitative interactions on the success and impact of aquatic IAS. Further, the effect of abiotic factors, such as habitat structure, have lacked consideration in ecological impact prediction for many high-profile IAS, with most data acquired through simplified assessments that do not account for real environmental complexities. In the present study, we assessed a potential facilitative interaction between a predatory invasive fish, the Ponto-Caspian round goby (Neogobius melanostomus), and an invasive bivalve, the Asian clam (Corbicula fluminea). We compared N. melanostomus functional responses (feeding-rates under different prey densities) to a co-occurring endangered European native analogue fish, the bullhead (Cottus gobio), in the presence of increased levels of habitat complexity driven by the accumulation of dead C. fluminea biomass that persists within the environment (i.e. 0, 10, 20 empty bivalve shells). Habitat complexity significantly influenced predation, with consumption in the absence of shells being greater than where 10 or 20 shells were present. However, at the highest shell density, invasive N. melanostomus maximum feeding-rates and functional response ratios were substantially higher than those of native C. gobio. Further, the Relative Impact Potential metric, by combining per capita effects and population abundances, indicated that higher shell densities exacerbate the relative impact of the invader. It therefore appears that N. melanostomus can better tolerate higher IAS shell abundances when foraging at high prey densities, suggesting the occurrence of an important facilitative interaction. Our data are thus fully congruent with field data that link establishment success of N. melanostomus with the presence of C. fluminea. Overall, we show that invader-driven benthic habitat complexity can alter the feeding-rates and thus impacts of predatory fishes, and highlight the importance of inclusion of abiotic factors in impact prediction assessments for IAS.
(401230) Jessie [or Janet] Bell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Supplementary information from Experimental evolution of parasitic host manipulation
Creators: name: Hafer-Hahmann, Nina
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: Ecology
subject: 60801 Animal Behaviour

description: The supplementary information contains supplementary tables that provide further statistical information, figures showing the pedigree of parasites used in this study (Fig. S1) and a picture of an infected copepod to illustrate traits measured in this study (Fig. S2), and a section providing more detailed information on potential trade-offs between host manipulation and other fitness related parasite traits.
A THESIS SUBMITTED TO THE SCHOOL OF GRADUATE STUDIES OF ADDIS ABABA UNIVERSITY IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF PUBLIC HEALTH IN EPIDEMIOLOGY AND BIOSTATISTICS
Creators: name: ZENAWI HAGOS GUFUE
Publisher: name: Zenodo
Year: 2019

description: Background: Globally, stroke appears as a major cause of preventable death and disability.

In Ethiopia, the intra-hospital mortality of stroke is significant and there is scarcity of

epidemiologic data whether there is a difference in the overall survival time between

hypertensive and non-hypertensive adult stroke patients admitted in specialized hospitals.

Objectives: To determine the survival of stroke patients according to their hypertension

status admitted in Ayder Comprehensive Specialized Hospital, Northern Ethiopia from

March 1, 2012 to February 28, 2019.
Comparing Perioperative Outcome Measures of the Dynamic Hip Screw and the Femoral Neck System
Creators: name: Niemann, Marcel
name: Braun, Karl F.
name: Ahmad, Sufian S.
name: Stöckle, Ulrich
name: Märdian, Sven
name: Graef, Frank
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: dynamic hip screw
subject: femoral neck system
subject: femoral neck fracture
subject: individual medicine
subject: minimal-invasive surgery
subject: multiple trauma
subject: geriatrics
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background and Objective: Various fixation devices and surgical techniques are available for the management of proximal femur fractures. Recently, the femoral neck system (FNS) was introduced, and was promoted on the basis of less invasiveness, shorter operating time, and less fluoroscopy time compared to previous systems. The aim of this study was to compare two systems for the internal fixation of femoral neck fractures (FNF), namely the dynamic hip screw (DHS) with an anti-rotation screw (ARS) and an FNS. The outcome measures included operating room time (ORT), dose–area product (DAP), length of stay (LOS), perioperative changes in haemoglobin concentrations, and transfusion rate. Materials and Methods: A retrospective single-centre study was conducted. Patients treated for FNF between 1 January 2020 and 30 September 2021 were included, provided that they had undergone closed reduction and internal fixation. We measured the centrum-collum-diaphyseal (CCD) and the Pauwels angle preoperatively and one week postoperatively. Results: In total, 31 patients (16 females), with a mean age of 62.81 ± 15.05 years, were included. Fracture complexity assessed by the Pauwels and Garden classification did not differ between groups preoperatively. Nonetheless, the ORT (54 ± 26.1 min vs. 91.68 ± 23.96 min, p < 0.01) and DAP (721 ± 270.6 cGycm² vs. 1604 ± 1178 cGycm², p = 0.03) were significantly lower in the FNS group. The pre- and postoperative CCD and Pauwels angles did not differ statistically between groups. Perioperative haemoglobin concentration changes (–1.77 ± 1.19 g/dl vs. –1.74 ± 1.37 g/dl) and LOS (8 ± 5.27 days vs. 7.35 ± 3.43 days) were not statistically different. Conclusions: In this cohort, the ORT and DAP were almost halved in the patient group treated with FNS. This may confer a reduction in secondary risks related to surgery.
Control of fixed points and existence and uniqueness of centric linking systems
Creators: name: Glauberman, George
name: Lynd, Justin
Publisher: name: arXiv
Year: 2015
Subjects: subject: Group Theory (math.GR)
subject: Algebraic Topology (math.AT)
subject: FOS: Mathematics
subject: 20D20, 20D05, 55R35, 55P60

description: A. Chermak has recently proved that to each saturated fusion system over a finite $p$-group, there is a unique associated centric linking system. B. Oliver extended Chermak's proof by showing that all the higher cohomological obstruction groups relevant to unique existence of centric linking systems vanish. Both proofs indirectly assume the classification of finite simple groups. We show how to remove this assumption, thereby giving a classification-free proof of the Martino-Priddy conjecture concerning the $p$-completed classifying spaces of finite groups. Our main tool is a 1971 result of the first author on control of fixed points by $p$-local subgroups. This result is directly applicable for odd primes, and we show how a slight variation of it allows applications for $p=2$ in the presence of offenders.
description: v1: 34pp; v2: 39pp, post-refereed version
(401229) Margaret Halliburton
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(401228) William Cochran
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
(401227) Margaret Hardy
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Contrasting Behavior of Conformationally Locked Carbocyclic Nucleosides of Adenosine and Cytidine as Substrates for Deaminases
Creators: name: Wolfenden, Richard
name: Ezzitouni, Abdallah
name: Ludek, Olaf R.
name: Schroeder, Gottfried K.
name: Marquez, Victor E.
name: Siddiqui, Maqbool A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: In addition to the already known differences between adenosine deaminase (ADA) and cytidine deaminase (CDA) in terms of their tertiary structure, the sphere of Zn+2 coordination, and their reverse stereochemical preference, we present evidence that the enzymes also differ significantly in terms of the North/South conformational preferences for their substrates and the extent to which the lack of the O(4’) oxygen affects the kinetics of the enzymatic deamination of carbocyclic substrates. The carbocyclic nucleoside substrates used in this study have either a flexible cyclopentane ring or a rigid bicyclo[3.1.0]hexane scaffold.
Predictions for the Top-Quark Forward-Backward Asymmetry at High Invariant Pair Mass Using the Principle of Maximum Conformality
Creators: name: Wang, Sheng-Quan
name: Wu, Xing-Gang
name: Si, Zong-Guo
name: Brodsky, Stanley J.
Publisher: name: arXiv
Year: 2015
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The D0 collaboration at FermiLab has recently measured the top-quark pair forward-backward asymmetry in $\bar p p \to t \bar{t} X$ reactions as a function of the $t\bar{t} $ invariant mass $M_{t\bar{t}}$. The D0 result for $A_{\rm FB}(M_{t\bar{t}}>650\, {\rm GeV})$ is smaller than $A_{\rm FB}(M_{t\bar{t}})$ obtained for small values of $M_{t\bar{t}}$, which may indicate an "increasing-decreasing" behavior for $A_{\rm FB}(M_{t\bar{t}}>M_{\rm cut})$. This behavior is not explained using conventional renormalization scale-setting, even by a next-to-next-to-leading order (N$^2$LO) QCD calculation -- one predicts a monotonically increasing behavior. In the conventional scale-setting method, one simply guesses a single renormalization scale $μ_r$ for the argument of the QCD running coupling and then varies it over an arbitrary range. However, the conventional method has inherent difficulties. ...... In contrast, if one fixes the scale using the Principle of Maximum Conformality (PMC), the resulting pQCD predictions are renormalization-scheme independent since all of the scheme-dependent $\{β_i\}$-terms in the QCD perturbative series are resummed into the QCD running couplings at each order. ...... In this paper we show that if one applies the PMC to determine the top versus anti-top quark forward-backward asymmetry by properly using the pQCD predictions up to N$^2$LO level, one obtains the predictions without renormalization scheme or scale ambiguities. ...... In addition, the PMC prediction for $A_{\rm FB}(M_{t\bar{t}}> M_{\rm cut})$ shows an "increasing-decreasing" behavior for increasing values of $M_{\rm cut}$ which is not observed in the NLO and N$^2$LO predictions for $A_{\rm FB}(M_{t\bar{t}}> M_{\rm cut})$ with conventional scale-setting. This behavior could be tested by the future more precise measurements at the LHC.
description: 7 pages, 2 figures. Revised version to be published in Phys.Rev.D
Drosophila Symplekin localizes dynamically to the histone locus body and tricellular junctions
Creators: name: Curry, Kaitlin P.
name: Witkowski, Alison M.
name: Rizzardi, Lindsay F.
name: Duronio, Robert J.
name: Marzluff, William F.
name: Tatomer, Deirdre C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: The scaffolding protein Symplekin is part of multiple complexes involved in generating and modifying the 3' end of mRNAs, including cleavage-polyadenylation, histone pre-mRNA processing and cytoplasmic polyadenylation. To study these functions in vivo, we examined the localization of Symplekin during development and generated mutations of the Drosophila Symplekin gene. Mutations in Symplekin that reduce Symplekin protein levels alter the efficiency of both poly A+ and histone mRNA 3' end formation resulting in lethality or sterility. Histone mRNA synthesis takes place at the histone locus body (HLB) and requires a complex composed of Symplekin and several polyadenylation factors that associates with the U7 snRNP. Symplekin is present in the HLB in the early embryo when Cyclin E/Cdk2 is active and histone genes are expressed and is absent from the HLB in cells that have exited the cell cycle. During oogenesis, Symplekin is preferentially localized to HLBs during S-phase in endoreduplicating follicle cells when histone mRNA is synthesized. After the completion of endoreplication, Symplekin accumulates in the cytoplasm, in addition to the nucleoplasm, and localizes to tricellular junctions of the follicle cell epithelium. This localization depends on the RNA binding protein ypsilon schachtel. CPSF-73 and a number of mRNAs are localized at this same site, suggesting that Symplekin participates in cytoplasmic polyadenylation at tricellular junctions.
(401226) William Bell
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
Stroke Genomics: Current Knowledge, Clinical Applications and Future Possibilities
Creators: name: Appunni, Sandeep
name: Rubens, Muni
name: Ramamoorthy, Venkataraghavan
name: Saxena, Anshul
name: McGranaghan, Peter
name: Veledar, Emir
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2022
Subjects: subject: stroke
subject: genomics
subject: Mendelian inheritance
subject: GWAS
subject: PheWAS
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: The pathophysiology of stoke involves many complex pathways and risk factors. Though there are several ongoing studies on stroke, treatment options are limited, and the prevalence of stroke is continuing to increase. Understanding the genomic variants and biological pathways associated with stroke could offer novel therapeutic alternatives in terms of drug targets and receptor modulations for newer treatment methods. It is challenging to identify individual causative mutations in a single gene because many alleles are responsible for minor effects. Therefore, multiple factorial analyses using single nucleotide polymorphisms (SNPs) could be used to gain new insight by identifying potential genetic risk factors. There are many studies, such as Genome-Wide Association Studies (GWAS) and Phenome-Wide Association Studies (PheWAS) which have identified numerous independent loci associated with stroke, which could be instrumental in developing newer drug targets and novel therapies. Additionally, using analytical techniques, such as meta-analysis and Mendelian randomization could help in evaluating stroke risk factors and determining treatment priorities. Combining SNPs into polygenic risk scores and lifestyle risk factors could detect stroke risk at a very young age and help in administering preventive interventions.
Polymer models of interphase chromosomes
Creators: name: Vasquez, Paula A.
name: Bloom, Kerry
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2014

description: Clear organizational patterns on the genome have emerged from the statistics of population studies of fixed cells. However, how these results translate into the dynamics of individual living cells remains unexplored. We use statistical mechanics models derived from polymer physics to inquire into the effects that chromosome properties and dynamics have in the temporal and spatial behavior of the genome. Overall, changes in the properties of individual chains affect the behavior of all other chains in the domain. We explore two modifications of chain behavior: single chain motion and chain-chain interactions. We show that there is not a direct relation between these effects, as increase in motion, doesn’t necessarily translate into an increase on chain interaction.
Supplementary information and statistical tables from Early-life manipulation of cortisol and its receptor alters stress axis programming and social competence.
Creators: name: Reyes-Contreras, Maria
name: Gaétan Glauser
name: Rennison, Diana J.
name: Taborsky, Barbara
Publisher: name: The Royal Society
Year: 2019
Subjects: subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: The supplementary information contains the ethogram of the behaviours recorded in this study (§1), supplementary methods including hormone sample preparation and RT-qPCR protocols (§2) and statistical tables with the results of the GLMMs and LMMs (§3).
(401225) Catherine Gordon
Creators: name: Professions, Victorian
Publisher: name: University of Oxford
Year: 2022
Subjects: subject: 220201 Business and Labour History
subject: FOS: Philosophy, ethics and religion
subject: History
subject: 140203 Economic History
subject: FOS: Economics and business

description: This three-year research project began in January 2014 and investigated whether, during the Victorian period, the professions formed a distinct self-sustaining social group with its own mores and values. The project looked at 16,000 individuals drawn from census data for Alnwick, Brighton, Bristol, Dundee, Greenock, Leeds, Merthyr Tydfil, Morpeth, and Winchester. The research project was funded by the UK Economic & Social Research Council and was based at the Universities of Oxford and Northumbria.
A Chemerin Peptide Analog Stimulates Tumor Growth in Two Xenograft Mouse Models of Human Colorectal Carcinoma
Creators: name: Friebus-Kardash, Justa
name: Schulz, Petra
name: Reinicke, Sandy
name: Karthaus, Cordula
name: Schefer, Quirino
name: Bandholtz, Sebastian
name: Grötzinger, Carsten
Publisher: name: Charité - Universitätsmedizin Berlin
Year: 2021
Subjects: subject: chemerin
subject: peptide analog
subject: CG34
subject: CMKLR1
subject: GPR1
subject: CCLR2
subject: colorectal cancer
subject: xenograft mouse model
subject: tumor treatment
subject: 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

description: Background: Chemerin plasma concentration has been reported to be positively correlated with the risk of colorectal cancer. However, the potential regulation of CRC tumorigenesis and progression has not yet been investigated in an experimental setting. This study addresses this hypothesis by investigating proliferation, colony formation, and migration of CRC cell lines in vitro as well as in animal models. Methods: In vitro, microscopic assays to study proliferation, as well as a scratch-wound assay for migration monitoring, were applied using the human CRC cell lines HCT116, HT29, and SW620 under the influence of the chemerin analog CG34. The animal study investigated HCT116-luc and HT29-luc subcutaneous tumor size and bioluminescence during treatment with CG34 versus control, followed by an ex-vivo analysis of vessel density and mitotic activity. Results: While the proliferation of the three CRC cell lines in monolayers was not clearly stimulated by CG34, the chemerin analog promoted colony formation in three-dimensional aggregates. An effect on cell migration was not observed. In the treatment study, CG34 significantly stimulated both growth and bioluminescence signals of HCT116-luc and HT29-luc xenografts. Conclusions: The results of this study represent the first indication of a tumor growth-stimulating effect of chemerin signaling in CRC.
Additional file 1 of Pre-notifications increase retention in a 17-year follow-up of adolescents born very preterm
Creators: name: Helin, Minttu
name: Karukivi, Max
name: Rautava, Päivi
name: Hirvonen, Milka
name: Huhtala, Mira
name: Setänen, Sirkku
Publisher: name: figshare
Year: 2023
Subjects: subject: Medicine
subject: Sociology
subject: FOS: Sociology
classificationCode: 69999
subject: Biological Sciences not elsewhere classified
subject: Science Policy

description: Additional file 1. Abbreviations with references of the Figure 1.
A combined first-principles and thermodynamic approach to M-Nitronyl Nitroxide (M=Co, Mn) spin helices
Creators: name: Scarrozza, Marco
name: Vindigni, Alessandro
name: Barone, Paolo
name: Sessoli, Roberta
name: Picozzi, Silvia
Publisher: name: arXiv
Year: 2015
Subjects: subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: The properties of two molecular-based magnetic helices, composed of 3$d$ metal Co and Mn ions bridged by Nitronyl Nitroxide radicals, are investigated by density functional calculations. Their peculiar and distinctive magnetic behavior is here elucidated by a thorough description of their magnetic, electronic, and anisotropy properties. Metal ions are antiferromagnetically coupled with the radicals, leading to a ferrimagnetically ordered ground state. A strong metal-radical exchange coupling is found, about 44 meV and 48 meV for Co- and Mn-helices, respectively. The latter have also relevant next-nearest-neighbor Mn-Mn antiferromagnetic interactions (of $\sim$ 6 meV). Co-sites are characterized by non-collinear uniaxial anisotropies, whereas Mn-sites are rather isotropic. A key result pertains to the Co-helix: the microscopic picture resulting from density-functional calculations allows us to propose a spin Hamiltonian of increased complexity with respect to the commonly employed Ising Hamiltonian, suitable for the study of finite-temperature behavior, and that seems to clarify the puzzling scenario of multiple characteristic energy scales observed in experiments.
description: 17 pages, 9 figures