cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Effect of geometry on concentration polarization in realistic heterogeneous permselective systems
Creators: name: Green, Yoav
name: Shloush, Shahar
name: Yossifon, Gilad
Publisher: name: arXiv
Year: 2014
Subjects: subject: Fluid Dynamics (physics.flu-dyn)
subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: This study extends previous analytical solutions of concentration-polarization occurring solely in the depleted region, to the more realistic geometry consisting of a three dimensional (3D) heterogeneous ion-permselective medium connecting two opposite microchambers (i.e. 3 layers system). Under the local electro-neutrality approximation, the separation of variable methods is used to derive an analytical solution of the electro-diffusive problem for the two opposing asymmetric microchambers. Assuming an ideal permselective medium allows for the analytic calculation of the 3D concentration and electric potential distributions as well as a current-voltage relation. It is shown that any asymmetry in the microchamber geometries will result in current rectification. Moreover, it is demonstrated that for non-negligible microchamber resistances the conductance does not exhibit the expected saturation at low concentrations but instead shows a continuous decrease. The results are intended to facilitate a more direct comparison between theory and experiments as now the voltage drop is across a realistic 3D and 3-layer system.
description: 7 figures
The Nuclear RhoA Exchange Factor Net1 Interacts with Proteins of the Dlg Family, Affects Their Localization, and Influences Their Tumor Suppressor Activity
Creators: name: Garcia-Mata, R.
name: Frost, J. A.
name: Dubash, A. D.
name: Sharek, L.
name: Burridge, K.
name: Carr, H. S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Net1 is a RhoA-specific guanine nucleotide exchange factor which localizes to the nucleus at steady state. A deletion in its N terminus redistributes the protein to the cytosol, where it activates RhoA and can promote transformation. Net1 contains a PDZ-binding motif at the C terminus which is essential for its transformation properties. Here, we found that Net1 interacts through its PDZ-binding motif with tumor suppressor proteins of the Dlg family, including Dlg1/SAP97, SAP102, and PSD95. The interaction between Net1 and its PDZ partners promotes the translocation of the PDZ proteins to nuclear subdomains associated with PML bodies. Interestingly, the oncogenic mutant of Net1 is unable to shuttle the PDZ proteins to the nucleus, although these proteins still associate as clusters in the cytosol. Our results suggest that the ability of oncogenic Net1 to transform cells may be in part related to its ability to sequester tumor suppressor proteins like Dlg1 in the cytosol, thereby interfering with their normal cellular function. In agreement with this, the transformation potential of oncogenic Net1 is reduced when it is coexpressed with Dlg1 or SAP102. Together, our results suggest that the interaction between Net1 and Dlg1 may contribute to the mechanism of Net1-mediated transformation.
A gap-sharing planet pair shaping the crescent in HD 163296: a disk sculpted by a resonant chain
Creators: name: Garrido-Deutelmoser, Juan
name: Petrovich, Cristobal
name: Charalambous, Carolina
name: Guzmán, Viviana V.
name: Zhang, Ke
Publisher: name: arXiv
Year: 2023
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: ALMA observations of the disk around HD 163296 have resolved a crescent-shape substructure at around 55 au, inside and off-center from a gap in the dust that extends from 38 au to 62 au. In this work we propose that both the crescent and the dust rings are caused by a compact pair (period ratio $\simeq 4:3$) of sub-Saturn-mass planets inside the gap, with the crescent corresponding to dust trapped at the $L_5$ Lagrange point of the outer planet. This interpretation also reproduces well the gap in the gas recently measured from the CO observations, which is shallower than what is expected in a model where the gap is carved by a single planet. Building on previous works arguing for outer planets at $\approx 86$ and $\approx 137$ au, we provide with a global model of the disk that best reproduces the data and show that all four planets may fall into a long resonant chain, with the outer three planets in a 1:2:4 Laplace resonance. We show that this configuration is not only an expected outcome from disk-planet interaction in this system, but it can also help constraining the radial and angular position of the planet candidates using three-body resonances.
description: 11 pages, 8 figures, re-submitted to ApJL, comments welcome
On the regularization of solution of an inverse ultraparabolic equation associated with perturbed final data
Creators: name: Khoa, Vo Anh
name: Lan, Le Trong
name: Tuan, Nguyen Huy
name: Hung, Tran The
Publisher: name: arXiv
Year: 2014
Subjects: subject: Analysis of PDEs (math.AP)
subject: Functional Analysis (math.FA)
subject: FOS: Mathematics
subject: 47A52, 20M17, 26D15

description: In this paper, we study the inverse problem for a class of abstract ultraparabolic equations which is well-known to be ill-posed. We employ some elementary results of semi-group theory to present the formula of solution, then show the instability cause. Since the solution exhibits unstable dependence on the given data functions, we propose a new regularization method to stabilize the solution. then obtain the error estimate. A numerical example shows that the method is efficient and feasible. This work slightly extends to the earlier results in Zouyed et al. \cite{key-9} (2014).
description: 19 pages, 4 figures, 1 table
On the round-trip time for a photon propagating in the field of a plane gravitational wave
Creators: name: Rakhmanov, Malik
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: A network of large-scale laser interferometers is currently employed for searches of gravitational waves from various astrophysical sources. The frequency dependence of the dynamic response of these detectors introduces corrections to their antenna patterns which in principle can affect the outcome of the associated data-analysis algorithms. The magnitude of these corrections and the corresponding systematic errors have recently been estimated for searches of periodic and stochastic gravitational waves (CQG 25 (2008) 184017). However, the calculation of the detector response in that paper followed the traditional semi-rigorous approach which does not properly take into account the curved nature of spacetime. The question then arises as to whether the results will be the same if the calculation is done within the rigorous framework of general relativity. In this paper we provide such a derivation of the response of the detectors to gravitational waves. We obtain the photon propagation time from the solution of the equation for null geodesics and calculate the corresponding phase delay by solving the eikonal equation for curved spacetime. The calculations are then extended to include phase amplification from multi-beam interference in Fabry-Perot resonators which play an important role in the formation of the signal in these detectors.
A Catalog of 71 Coronal Line Galaxies in MaNGA: [NeV] is an Effective AGN Tracer
Creators: name: Negus, James
name: Comerford, Julia M.
name: Sanchez, Francisco Muller
name: Revalski, Mitchell
name: Riffel, Rogemar A.
name: Bundy, Kevin
name: Nevin, Rebecca
name: Rembold, Sandro B.
Publisher: name: arXiv
Year: 2023
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Despite the importance of AGN in galaxy evolution, accurate AGN identification is often challenging, as common AGN diagnostics can be confused by contributions from star formation and other effects (e.g., Baldwin-Phillips-Terlevich diagrams). However, one promising avenue for identifying AGNs are ``coronal emission lines" (``CLs"), which are highly ionized species of gas with ionization potentials $\ge$ 100 eV. These CLs may serve as excellent signatures for the strong ionizing continuum of AGN. To determine if CLs are in fact strong AGN tracers, we assemble and analyze the largest catalog of optical CL galaxies using the Sloan Digital Sky Survey's Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) catalog. We detect CL emission in 71 MaNGA galaxies, out of the 10,010 unique galaxies from the final MaNGA catalog, with $\ge$ 5$σ$ confidence. In our sample, we measure [NeV]$λ$3347, $λ$3427, [FeVII]$λ$3586, $λ$3760, $λ$6086, and [FeX]$λ$6374 emission and crossmatch the CL galaxies with a catalog of AGNs that were confirmed with broad line, X-ray, IR, and radio observations. We find that [NeV] emission, compared to [FeVII] and [FeX] emission, is best at identifying high luminosity AGN. Moreover, we find that the CL galaxies with the least dust extinction yield the most iron CL detections. We posit that the bulk of the iron CLs are destroyed by dust grains in the galaxies with the highest [OIII] luminosities in our sample, and that AGN in the galaxies with low [OIII] luminosities are possibly too weak to be detected using traditional techniques.
description: 21 pages, 6 figures, 8 tables
The RNA Polymerase II Kinase Ctk1 Regulates Positioning of a 5' Histone Methylation Boundary along Genes
Creators: name: Shibata, Y.
name: Rao, B.
name: O'Rourke, R.
name: Laribee, R. N.
name: Xiao, T.
name: Krogan, N. J.
name: Greenblatt, J. F.
name: Buck, M. J.
name: Lieb, J. D.
name: Strahl, B. D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: In yeast and other eukaryotes, the histone methyltransferase Set1 mediates methylation of lysine 4 on histone H3 (H3K4me). This modification marks the 5′ end of transcribed genes in a 5′-to-3′ tri- to di- to monomethyl gradient and promotes association of chromatin-remodeling and histone-modifying enzymes. Here we show that Ctk1, the serine 2 C-terminal domain (CTD) kinase for RNA polymerase II (RNAP II), regulates H3K4 methylation. We found that CTK1 deletion nearly abolished H3K4 monomethylation yet caused a significant increase in H3K4 di- and trimethylation. Both in individual genes and genome-wide, loss of CTK1 disrupted the H3K4 methylation patterns normally observed. H3K4me2 and H3K4me3 spread 3′ into the bodies of genes, while H3K4 monomethylation was diminished. These effects were dependent on the catalytic activity of Ctk1 but are independent of Set2-mediated H3K36 methylation. Furthermore, these effects are not due to spurious transcription initiation in the bodies of genes, to changes in RNAP II occupancy, to changes in serine 5 CTD phosphorylation patterns, or to “transcriptional stress.” These data show that Ctk1 acts to restrict the spread of H3K4 methylation through a mechanism that is independent of a general transcription defect. The evidence presented suggests that Ctk1 controls the maintenance of suppressive chromatin in the coding regions of genes by both promoting H3K36 methylation, which leads to histone deacetylation, and preventing the 3′ spread of H3K4 trimethylation, a mark associated with transcriptional initiation.
Diamond Nanophotonics
Creators: name: Aharonovich, Igor
name: Neu, Elke
Publisher: name: arXiv
Year: 2014
Subjects: subject: Quantum Physics (quant-ph)
subject: Materials Science (cond-mat.mtrl-sci)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: The burgeoning field of nanophotonics has grown to be a major research area, primarily because of the ability to control and manipulate single quantum systems (emitters) and single photons on demand. For many years studying nanophotonic phenomena was limited to traditional semiconductors (including silicon and GaAs) and experiments were carried out predominantly at cryogenic temperatures. In the last decade, however, diamond has emerged as a new contender to study photonic phenomena at the nanoscale. Offering plethora of quantum emitters that are optically active at room temperature and ambient conditions, diamond has been exploited to demonstrate super-resolution microscopy and realize entanglement, Purcell enhancement and other quantum and classical nanophotonic effects. Elucidating the importance of diamond as a material, this review will highlight the recent achievements in the field of diamond nanophotonics, and convey a roadmap for future experiments and technological advancements.
description: Advanced Optical Materials (2014)
The Saccharomyces cerevisiae Histone Demethylase Jhd1 Fine-Tunes the Distribution of H3K36me2
Creators: name: Hogan, G. J.
name: Fang, J.
name: Liang, G.
name: Zhang, Y.
name: Lieb, J. D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: Histone methylation plays important roles in the regulation of chromatin dynamics and transcription. Steady-state levels of histone lysine methylation are regulated by a balance between enzymes that catalyze either the addition or removal of methyl groups. Using an activity-based biochemical approach, we recently uncovered the JmjC domain as an evolutionarily conserved signature motif for histone demethylases. Furthermore, we demonstrated that Jhd1, a JmjC domain-containing protein in Saccharomyces cerevisiae, is an H3K36-specific demethylase. Here we report further characterization of Jhd1. Similar to its mammalian homolog, Jhd1-catalyzed histone demethylation requires iron and α-ketoglutarate as cofactors. Mutation and deletion studies indicate that the JmjC domain and adjacent sequences are critical for Jhd1 enzymatic activity, while the N-terminal PHD domain is dispensable. Overexpression of JHD1 results in a global reduction of H3K36 methylation in vivo. Finally, chromatin immunoprecipitation-coupled microarray studies reveal subtle changes in the distribution of H3K36me2 upon overexpression or deletion of JHD1. Our studies establish Jhd1 as a histone demethylase in budding yeast and suggest that Jhd1 functions to maintain the fidelity of histone methylation patterns along transcription units.
ความรู้ทักษะด้านเทคโนโลยีดิจิทัลในวิถีชีวิตใหม่ของบุคลากร สำนักหอสมุดกลาง มหาวิทยาลัยรามคำแหง
Creators: name: ชลวิทย์ จิตมาน
Publisher: name: Department of Strategics for Improving Education Quality, Surindra Rajabhat University
Year: 2023
Subjects: การรู้จักใช้เทคโนโลยี
เทคโนโลยีดิจิทัล
ชีวิตวิถีใหม่
ทักษะการใช้เทคโนโลยีสารสนเทศ

description: วารสารราชภัฏสุรินทร์วิชาการ, 1, 5, 15-32
Restitution des résultats de l'enquête Libqual + _ SCD Université Toulouse Capitole
Creators: name: Bolze Véronique,
Publisher: name: Zenodo
Year: 2023
Subjects: Libqual +, infographie, résultats d'enquête, évaluation

description: Document constitué pour communication auprès de la communauté universitaire des résultats de l'enquête Libqual + et des actions envisagées. Document diffusé sous forme d'affiche et en version électronique sur le site de l'université et les réseaux sociaux.
Electromagnetic media with Higgs-type spontaneously broken transparency
Creators: name: Itin, Yakov
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: In the framework of standard electrodynamics with linear local response, we construct a model that provides spontaneously broken transparency. The functional dependence of the medium parameter turns out to be of the Higgs type.
description: 3 pages, 5 figures
Indirect constraints on the Georgi-Machacek model and implications for Higgs couplings
Creators: name: Hartling, Katy
name: Kumar, Kunal
name: Logan, Heather E.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We update the indirect constraints on the Georgi-Machacek model from $B$-physics and electroweak precision observables, including new constraints from $b \to s γ$ and $B^0_s \to μ^+ μ^-$. We illustrate the effect of these constraints on the couplings of the Standard Model-like Higgs boson by performing scans using the most general scalar potential, subject to vacuum stability and perturbativity constraints. We find that simultaneous enhancements of all the Higgs production cross sections by up to 39\% are still allowed after imposing these constraints. LHC rate measurements on the Higgs pole could be blind to these enhancements if unobserved non-standard Higgs decays are present.
description: 20 pages, 6 figures
Moduli space metric for maximally-charged dilaton black holes
Creators: name: Shiraishi, Kiyoshi
Publisher: name: arXiv
Year: 2014
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: The system consisting of slowly-moving, maximally charged, nonrotating dilaton black holes is investigated. We obtain the metric on the moduli space of the system in the low-velocity limit. We find that: (1) only two-body interactions exist between the extreme black holes in string theory; (2) the mutual interaction between the black holes vanishes if the dilaton can be interpreted as a Kaluza-Klein scalar; and (3) for general dilaton couplings, there exist many-body interactions among the extreme black holes. We analyze the low-energy classical scattering of the two extreme black holes in string theory by utilizing the moduli space metric.
description: 11 pages, 2 figure files
VHL Promotes E2 Box-Dependent E-Cadherin Transcription by HIF-Mediated Regulation of SIP1 and Snail
Creators: name: Russell, R. C.
name: Roberts, A. M.
name: Jewett, M. A. S.
name: Berx, G.
name: Ohh, M.
name: Saravanan, A.
name: Marsden, P. A.
name: Gervais, M. L.
name: Evans, A. J.
name: Roche, O.
name: Chow, V. W. K.
name: Teh, B. T.
name: Kim, W. Y.
name: Wilson, L. A.
name: Burry, T. N.
name: Vandewalle, C.
name: Fish, J. E.
name: Betten, M.
name: Irwin, M. S.
name: Maynard, M. A.
name: Sufan, R. I.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2007

description: The product of the von Hippel-Lindau gene (VHL) acts as the substrate-recognition component of an E3 ubiquitin ligase complex that ubiquitylates the catalytic α subunit of hypoxia-inducible factor (HIF) for oxygen-dependent destruction. Although emerging evidence supports the notion that deregulated accumulation of HIF upon the loss of VHL is crucial for the development of clear-cell renal cell carcinoma (CC-RCC), the molecular events downstream of HIF governing renal oncogenesis remain unclear. Here, we show that the expression of a homophilic adhesion molecule, E-cadherin, a major constituent of epithelial cell junctions whose loss is associated with the progression of epithelial cancers, is significantly down-regulated in primary CC-RCC and CC-RCC cell lines devoid of VHL. Reintroduction of wild-type VHL in CC-RCC (VHL−/−) cells markedly reduced the expression of E2 box-dependent E-cadherin-specific transcriptional repressors Snail and SIP1 and concomitantly restored E-cadherin expression. RNA interference-mediated knockdown of HIFα in CC-RCC (VHL−/−) cells likewise increased E-cadherin expression, while functional hypoxia or expression of VHL mutants incapable of promoting HIFα degradation attenuated E-cadherin expression, correlating with the disengagement of RNA polymerase II from the endogenous E-cadherin promoter/gene. These findings reveal a critical HIF-dependent molecular pathway connecting VHL, an established “gatekeeper” of the renal epithelium, with a major epithelial tumor suppressor, E-cadherin.
The view from here
Creators: name: JANE KATHRYN CONNORY
Publisher: name: Monash University
Year: 2019
Subjects: subject: 120307 Visual Communication Design (incl. Graphic Design)
subject: FOS: Arts (arts, history of arts, performing arts, music)
subject: 120301 Design History and Theory
subject: Gender studies
subject: Design

description: Exploring the causes of invisibility for women in Australian graphic design and advocating for their equity and autonomy
Antibiotic resistance of aquatic bacteria and it's implications for limnological research
Creators: name: Boon, Paul I
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

The antibiotic resistance of bacteria from the water column of various rivers and billabongs in north-eastern Victoria was studied during 1988-91. Two indices were used as measures of resistance: conventional disc-sensitivity tests with culturable bacteria, and the effect of antibiotics on the uptake of 14C-glucose and 14C-amino acids by native bacterial assemblages. Culturable bacteria were resistant to ampicillin, methicillin and penicillin but generally sensitive to nalidixic acid, neomycin, streptomycin, sulfafurazole and tetracycline. Responses to chloramphenicol, erythromycin, nitrofurantoin and sulfamethizole were variable. Bacteria isolated from rivers were more resistant to antibiotics than were those isolated from billabongs. Methicillin, even at 200 mg L-1, had little effect on the uptake of 14C-labelled compounds. Nalidic acid (20 mg L-1) also was ineffective unless lengthy pre-incubations (24 h) were used. Chloramphenicol and tetracycline at 20 mg L-1 markedly reduced amino acid uptake but not glucose uptake. The widespread antibiotic resistance of aquatic bacteria casts doubt on the suitability of these compounds to selectively inhibit the prokaryotic component in ecological studies and may be cause for concern regarding the spread of antibiotic resistance through natural aquatic communities.
The Inside-out Growth of the Most Massive Galaxies at 0.3
Creators: name: Bai, Lei
name: Yee, H. K. C.
name: Yan, Renbin
name: Lee, Eve
name: Gilbank, David G.
name: Ellingson, E.
name: Barrientos, L. F.
name: Gladders, M. D.
name: Hsieh, B. C.
name: Li, I. H.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: We study the surface brightness profiles of a sample of brightest cluster galaxies (BCGs) with 0.3
description: 23 pages, 11 figures, 6 tables, accepted for publication in ApJ, fixed typos
การพัฒนาความสามารถในการให้เหตุผลทางคณิตศาสตร์เรื่องตรรกศาสตร์ โดยใช้การจัดการเรียนรู้แบบเกมมิฟิเคชัน สำหรับนักเรียนระดับชั้นมัธยมศึกษาปีที่ 4
Creators: name: วุฒิพงษ์ สมมิตร
Publisher: name: Department of Strategics for Improving Education Quality, Surindra Rajabhat University
Year: 2023
Subjects: ความสามารถในการให้เหตุผลทางคณิตศาสตร์
เกมมิฟิเคชัน
ตรรกศาสตร์
แรงจูงใจใฝ่สัมฤทธิ์

description: วารสารราชภัฏสุรินทร์วิชาการ, 1, 5, 33-48
An integrated low phase noise radiation-pressure-driven optomechanical oscillator chipset
Creators: name: Luan, X.
name: Huang, Y.
name: Li, Y.
name: McMillan, J. F.
name: Zheng, J.
name: Huang, S. -W.
name: Hsieh, P. -C.
name: Gu, T.
name: Wang, D.
name: Hati, A.
name: Howe, D. A.
name: Wen, G.
name: Yu, M.
name: Lo, G.
name: Kwong, D. -L.
name: Wong, C. W.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: High-quality frequency references are the cornerstones in position, navigation and timing applications of both scientific and commercial domains. Optomechanical oscillators, with direct coupling to continuous-wave light and non-material-limited f Q product, are long regarded as a potential platform for frequency reference in radio-frequency-photonic architectures. However, one major challenge is the compatibility with standard CMOS fabrication processes while maintaining optomechanical high quality performance. Here we demonstrate the monolithic integration of photonic crystal optomechanical oscillators and on-chip high speed Ge detectors based on the silicon CMOS platform. With the generation of both high harmonics (up to 59th order) and subharmonics (down to 1/4), our chipset provides multiple frequency tones for applications in both frequency multipliers and dividers. The phase noise is measured down to -125 dBc/Hz at 10 kHz offset at ~ 400 μW dropped-in powers, one of the lowest noise optomechanical oscillators to date and in room-temperature and atmospheric non-vacuum operating conditions. These characteristics enable optomechanical oscillators as a frequency reference platform for radio-frequency-photonic information processing.
description: 32 pages, 13 figures
Australia’s neglected freshwater microfauna
Creators: name: Green, John D
name: Shiel, Russell J
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

The composition, function and importance of zooplankton and littoral microfaunal communities in Australian freshwaters are discussed. Relative to global studies, these groups have been neglected. These is a diverse endemic microfauna in Australia, but much of it is undescribed or incorrectly identified because of over-reliance on northern hemisphere taxonomy. The importance of these animals in freshwater ecosystems, for example in regulating algal abundance and as fish food, has been under-estimated or ignored in Australia.
Présentation réorganisation fonctionnelle_SCD Toulouse Capitole _2014
Creators: name: CASTILLON, Magali
Publisher: name: Zenodo
Year: 2023
Subjects: Reorganisation fonctionnelle, Organisation, Pilotage

description: Document de présentation de la réorganisation fonctionnelle du SCD Toulouse Capitole menée en 2014 et mise en oeuvre le 01/01/2015
ATP Binding by Monarch-1/NLRP12 Is Critical for Its Inhibitory Function
Creators: name: Williams, K. L.
name: Duncan, J. A.
name: Ye, Z.
name: Moore, C. B.
name: Ting, J. P.-Y.
name: Lich, J. D.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The recently discovered nucleotide binding domain-leucine rich repeat (NLR) gene family is conserved from plants to mammals, and several members are associated with human autoinflammatory or immunodeficiency disorders. This family is defined by a central nucleotide binding domain that contains the highly conserved Walker A and Walker B motifs. Although the nucleotide binding domain is a defining feature of this family, it has not been extensively studied in its purified form. In this report, we show that purified Monarch-1/NLRP12, an NLR protein that negatively regulates NF-κB signaling, specifically binds ATP and exhibits ATP hydrolysis activity. Intact Walker A/B motifs are required for this activity. These motifs are also required for Monarch-1 to undergo self-oligomerization, Toll-like receptor- or CD40L-activated association with NF-κB-inducing kinase (NIK) and interleukin-1 receptor-associated kinase 1 (IRAK-1), degradation of NIK, and inhibition of IRAK-1 phosphorylation. The stable expression of a Walker A/B mutant in THP-1 monocytes results in increased production of proinflammatory cytokines and chemokines to an extent comparable to that in cells in which Monarch-1 is silenced via short hairpin RNA. The results of this study are consistent with a model wherein ATP binding regulates the anti-inflammatory activity of Monarch-1.
การส่งเสริมการท่องเที่ยวเชิงวัฒนธรรมชุมชน “ปราสาทบ้านไพล” จังหวัดสุรินทร์
Creators: name: ยโสธารา ศิริภาประภากร
Publisher: name: Department of Strategics for Improving Education Quality, Surindra Rajabhat University
Year: 2023
Subjects: การส่งเสริมการท่องเที่ยวเชิงวัฒนธรรมชุมชน
ปราสาทบ้านไพล
จังหวัดสุรินทร์

description: วารสารราชภัฏสุรินทร์วิชาการ, 1, 5, 49-66
Anomalous magnetic moment of hot quarks, inverse magnetic catalysis and reentrance of chiral symmetry broken phase
Creators: name: Fayazbakhsh, Sh.
name: Sadooghi, N.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Theory (hep-th)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The effect of anomalous magnetic moment of quarks on thermodynamic properties of the chiral condensate is studied, using of a two-flavor Nambu--Jona-Lasinio model at finite temperature $T$, chemical potential $μ$, and in the presence of a uniform magnetic field $eB$. To this purpose, the Schwinger linear-in-$B$ ansatz for the quark anomalous magnetic moment in term of the nonperturbative Bohr magneton is considered. In a two-dimensional flavor space, it leads to the correction $\hat{T}_{Sch}=\hatκ\hat{Q} eB$ in the energy dispersion relation of quarks. Here, $\hat{Q}$ is the quark charge matrix. We consider three different sets for $\hatκ$, and numerically determine the dependence of the constituent quark mass on $T,μ$ and $eB$ for fixed $\hatκ$. By exploring the complete phase portrait of this model in $T$-$μ$, $μ$-$eB$, and $T$-$eB$ phase spaces for various fixed $eB$, $T$, $μ$ and $\hatκ$, we observe that inverse magnetic catalysis occurs for large enough $\hatκ$. Moreover, in the regime of weak magnetic fields, the phenomenon of reentrance of chiral symmetry broken and restored phases occurs for $T, μ$ and $eB$ dependent $\hatκ$.
description: 22 pages, 14 figures
Biogeochemistry of billabong sediments. II. Seasonal variations in methane production
Creators: name: Sorrell, Brian K
name: Boon, Paul I
Publisher: name: La Trobe
Year: 2023

description: Murray-Darling Freshwater Research Centre

MDFRC item.

1. We examined the temporal (seasonal and diel) and spatial variation in methane flux from sediments of a billabong in south-eastern Australia, and related it to variations in the rate of organic matter decay, concentration of interstitial metabolites, and sediment redox.2. Total gas ebullition ranged from <2 to >59mlm−2h−1, and was highest in the summer months when water temperatures were >25°C. These rates are equivalent to carbon fluxes of about 16–30gC—CH4m−2yr−1. Ebullition was greater from unvegetated sediments than from sediments colonized by the emergent macrophyte Eleockaris sphacelata, R, Br. or the submerged macrophyte Vallisneria gigantea Graeb. There were no consistent differences in the rate of ebullition over the day and the night.3. Methane accounted for about 42–45% of total sediment gas in the vegetated sediments, but about 60% in the unvegetated sediments. These ratios did not vary greatly throughout the year. Carbon dioxide was a minor component of sediment gas, usually comprising <5% of the total. Carbon dioxide contents were highest in summer, especially in unvegetated and E. sphacelata beds.4. In vitro methanogenesis ranged from 3 ± 0.9 to 106 ± 30 nmol g(dry weight)−1 h−1, being highest in summer and lowest in winter. Added acetate (5mM) increased the rate of methanogenesis by up to 10-fold, with the effect being greater in summer than winter. Generally, added acetate had least effect in E. sphacelata sediments. The maximum rate of in vitro methanogenesis with added acetate was 243 ± 57 nmolg(dry weight)−1 h−1.5. Ebullition was highly correlated with the rate of in vitro methanogenesis, with a rime lag of about 4 weeks. About 35–60% of benthic in vitro methanogenesis could be accounted for by ebullitive loss: the remainder was presumably lost via diffusion, flux through emergent plants or by oxidation. The rate of organic-matter degradation, assessed with amylopectin azure, varied throughout the year, but there was no clear relationship between ebullition and organic-matter decay.6. Concentrations of interstitial ammonium, which also varied seasonally, ranged from 1 ± 0.2 to 13 ± 1 mgNl−1. There was no clear relationship between ebullition rates and ammonium concentrations, Redox potential was most positive in the E. sphacelata sediments, but there was little consistent difference in the redox potential of V. gigantea and unvegetated sediments. Redox potential appeared not to be a controlling factor in methane release.
CHIP Deficiency Decreases Longevity, with Accelerated Aging Phenotypes Accompanied by Altered Protein Quality Control
Creators: name: Portbury, A. L.
name: Lockyer, P.
name: Sharpless, N. E.
name: Whaley, R. A.
name: Min, J.-N.
name: Patterson, C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: During the course of biological aging, there is a gradual accumulation of damaged proteins and a concomitant functional decline in the protein degradation system. Protein quality control is normally ensured by the coordinated actions of molecular chaperones and the protein degradation system that collectively help to maintain protein homeostasis. The carboxyl terminus of Hsp70-interacting protein (CHIP), a ubiquitin ligase/cochaperone, participates in protein quality control by targeting a broad range of chaperone substrates for proteasome degradation via the ubiquitin-proteasome system, demonstrating a broad involvement of CHIP in maintaining cytoplasmic protein quality control. In the present study, we have investigated the influence that protein quality control exerts on the aging process by using CHIP−/− mice. CHIP deficiency in mice leads to a markedly reduced life span, along with accelerated age-related pathophysiological phenotypes. These features were accompanied by indications of accelerated cellular senescence and increased indices of oxidative stress. In addition, CHIP−/− mice exhibit a deregulation of protein quality control, as indicated by elevated levels of toxic oligomer proteins and a decline in proteasome activity. Taken together, these data reveal that impaired protein quality control contributes to cellular senescence and implicates CHIP-dependent quality control mechanisms in the regulation of mammalian longevity in vivo.
การจัดการเรียนรู้โดยใช้คำถามเป็นฐาน
Creators: name: จุฑาทิพย์ หาญกุดตุ้ม
Publisher: name: Department of Strategics for Improving Education Quality, Surindra Rajabhat University
Year: 2023
Subjects: การจัดการเรียนรู้เชิงรุก
การประเมินผลทางเลือกใหม่
การเรียนรู้โดยใช้คำถามเป็นฐาน

description: วารสารราชภัฏสุรินทร์วิชาการ, 1, 5, 67-82
Epidermal Growth Factor-Dependent Phosphorylation and Ubiquitinylation of MAGE-11 Regulates Its Interaction with the Androgen Receptor
Creators: name: Wilson, E. M.
name: Bai, S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: The androgen receptor (AR) is a ligand-activated transcription factor that interacts with coregulatory proteins during androgen-dependent gene regulation. Melanoma antigen gene protein 11 (MAGE-11) is an AR coregulator that specifically binds the AR NH2-terminal FXXLF motif and modulates the AR NH2- and carboxyl-terminal N/C interaction to increase AR transcriptional activity. Here we demonstrate that epidermal growth factor (EGF) signaling increases androgen-dependent AR transcriptional activity through the posttranslational modification of MAGE-11. EGF in the presence of dihydrotestosterone stabilizes the AR-MAGE complex through the site-specific phosphorylation of MAGE-11 at Thr-360 and ubiquitinylation at Lys-240 and Lys-245. The time-dependent EGF-induced increase in AR transcriptional activity by MAGE-11 is mediated through AR activation functions 1 and 2 in association with the increased turnover of AR and MAGE-11. The results reveal a dynamic mechanism whereby growth factor signaling increases AR transcriptional activity through the covalent modification of an AR-specific coregulatory protein. Sequence conservation of the MAGE-11 phosphorylation and ubiquitinylation sites throughout the MAGE gene family suggests common regulatory mechanisms for this group of cancer-testis antigens.
Essential Role for Epidermal Growth Factor Receptor in Glutamate Receptor Signaling to NF- B
Creators: name: Sitcheran, R.
name: Baldwin, A. S.
name: Comb, W. C.
name: Cogswell, P. C.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Glutamate is a critical neurotransmitter of the central nervous system (CNS) and also an important regulator of cell survival and proliferation. The binding of glutamate to metabotropic glutamate receptors induces signal transduction cascades that lead to gene-specific transcription. The transcription factor NF-κB, which regulates cell proliferation and survival, is activated by glutamate; however, the glutamate receptor-induced signaling pathways that lead to this activation are not clearly defined. Here we investigate the glutamate-induced activation of NF-κB in glial cells of the CNS, including primary astrocytes. We show that glutamate induces phosphorylation, nuclear accumulation, DNA binding, and transcriptional activation function of glial p65. The glutamate-induced activation of NF-κB requires calcium-dependent IκB kinase α (IKKα) and IKKβ activation and induces p65-IκBα dissociation in the absence of IκBα phosphorylation or degradation. Moreover, glutamate-induced IKK preferentially targets the phosphorylation of p65 but not IκBα. Finally, we show that the ability of glutamate to activate NF-κB requires cross-coupled signaling with the epidermal growth factor receptor. Our results provide insight into a glutamate-induced regulatory pathway distinct from that described for cytokine-induced NF-κB activation and have important implications with regard to both normal glial cell physiology and pathogenesis.
Human Immunodeficiency Virus Type 1 Vpr-Binding Protein VprBP, a WD40 Protein Associated with the DDB1-CUL4 E3 Ubiquitin Ligase, Is Essential for DNA Replication and Embryonic Development
Creators: name: Xiong, Y.
name: He, Y. J.
name: Jackson, S. C.
name: Chastain, P. D.
name: Miliani de Marval, P. L.
name: Cook, J. G.
name: Kotake, Y.
name: McCall, C. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Damaged DNA binding protein 1, DDB1, bridges an estimated 90 or more WD40 repeats (DDB1-binding WD40, or DWD proteins) to the CUL4-ROC1 catalytic core to constitute a potentially large number of E3 ligase complexes. Among these DWD proteins is the human immunodeficiency virus type 1 (HIV-1) Vpr-binding protein VprBP, whose cellular function has yet to be characterized but has recently been found to mediate Vpr-induced G2 cell cycle arrest. We demonstrate here that VprBP binds stoichiometrically with DDB1 through its WD40 domain and through DDB1 to CUL4A, subunits of the COP9/signalsome, and DDA1. The steady-state level of VprBP remains constant during interphase and decreases during mitosis. VprBP binds to chromatin in a DDB1-independent and cell cycle-dependent manner, increasing from early S through G2 before decreasing to undetectable levels in mitotic and G1 cells. Silencing VprBP reduced the rate of DNA replication, blocked cells from progressing through the S phase, and inhibited proliferation. VprBP ablation in mice results in early embryonic lethality. Conditional deletion of the VprBP gene in mouse embryonic fibroblasts results in severely defective progression through S phase and subsequent apoptosis. Our studies identify a previously unknown function of VprBP in S-phase progression and suggest the possibility that HIV-1 Vpr may divert an ongoing chromosomal replication activity to facilitate viral replication.
Stable accretion and episodic outflows in the young transition disk system GM Aurigae
Creators: name: Bouvier, J.
name: Sousa, A.
name: Pouilly, K.
name: Almenara, J. M.
name: Donati, J. -F.
name: Alencar, S. H. P.
name: Frasca, A.
name: Grankin, K.
name: Carmona, A.
name: Pantolmos, G.
name: Zaire, B.
name: Bonfils, X.
name: Bayo, A.
name: Rebull, L. M.
name: Alonso-Santiago, J.
name: Gameiro, J. F.
name: Cook, N. J.
name: Artigau, E.
name: Survey, the SPIRou Legagy
name: Consortium
Publisher: name: arXiv
Year: 2023
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We investigate the structure and dynamics of the magnetospheric accretion region and associated outflows on a scale smaller than 0.1 au around the young transitional disk system GM Aur. We monitored the variability of the system on timescales ranging from days to months, using high-resolution optical and near-infrared spectroscopy, multiwavelength photometry, and low-resolution near-infrared spectroscopy, over a total duration of six months (30 rotational cycles). We analyzed the photometric and line profile variability to characterize the accretion and ejection processes. The luminosity of the system is modulated by surface spots at the stellar rotation period of 6.04 days. The Balmer, Paschen, and Brackett hydrogen lines as well as the HeI 5876 A and HeI 10830 A line profiles are modulated on the same period. The PaB line flux correlates with the photometric excess in the u' band, which suggests that most of the line emission originates from the accretion process. High-velocity redshifted absorptions reaching below the continuum periodically appear in the near-infrared line profiles at the rotational phase in which the veiling and line fluxes are the largest. These are signatures of a stable accretion funnel flow and associated accretion shock at the stellar surface. This large-scale magnetospheric accretion structure appears fairly stable over at least 15 and possibly up to 30 rotational periods. In contrast, outflow signatures randomly appear as blueshifted absorption components in the Balmer and HeI 10830 A line profiles and disappear on a timescale of a few days. The coexistence of a stable, large-scale accretion pattern and episodic outflows supports magnetospheric ejections as the main process occurring at the star-disk interface. Stable magnetospheric accretion and episodic outflows appear to be physically linked on a scale of a few stellar radii in this system.
description: 30 pages, 28 figures, 12 tables, accepted for publication in Astronomy & Astrophysics
Mice Lacking Homer 1 Exhibit a Skeletal Myopathy Characterized by Abnormal Transient Receptor Potential Channel Activity
Creators: name: Zhang, S.
name: Burch, J.
name: Williams, R. S.
name: Worley, P. F.
name: Zhang, Z.-S.
name: Yamaguchi, N.
name: Eu, J. P.
name: Rosenberg, P. B.
name: Truskey, G. A.
name: Meissner, G.
name: Seth, M.
name: Stiber, J. A.
name: Shah, R.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Transient receptor potential (TRP) channels are nonselective cation channels, several of which are expressed in striated muscle. Because the scaffolding protein Homer 1 has been implicated in TRP channel regulation, we hypothesized that Homer proteins play a significant role in skeletal muscle function. Mice lacking Homer 1 exhibited a myopathy characterized by decreased muscle fiber cross-sectional area and decreased skeletal muscle force generation. Homer 1 knockout myotubes displayed increased basal current density and spontaneous cation influx. This spontaneous cation influx in Homer 1 knockout myotubes was blocked by reexpression of Homer 1b, but not Homer 1a, and by gene silencing of TRPC1. Moreover, diminished Homer 1 expression in mouse models of Duchenne's muscular dystrophy suggests that loss of Homer 1 scaffolding of TRP channels may contribute to the increased stretch-activated channel activity observed in mdx myofibers. These findings provide direct evidence that Homer 1 functions as an important scaffold for TRP channels and regulates mechanotransduction in skeletal muscle.
The Hamburg/ESO R-process Enhanced Star survey (HERES) X. HE 2252-4225, one more r-process enhanced and actinide-boost halo star
Creators: name: Mashonkina, L.
name: Christlieb, N.
name: Eriksson, K.
Publisher: name: arXiv
Year: 2014
Subjects: subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: FOS: Physical sciences

description: We report on a detailed abundance analysis of the r-process enhanced giant star, HE 2252-4225 ([Fe/H] = -2.63, [r/Fe] = 0.80). Determination of stellar parameters and element abundances was based on analysis of high-quality VLT/UVES spectra. The surface gravity was calculated from the NLTE ionisation balance between Fe I and Fe II. Accurate abundances were determined for a total of 38 elements, including 22 neutron-capture elements beyond Sr and up to Th. This object is deficient in carbon, as expected for a giant star with Teff < 4800 K. The stellar Na-Zn abundances are well fitted by the yields of a single supernova of 14.4 Msun. For the neutron-capture elements in the Sr-Ru, Ba-Yb, and Os-Ir regions, the abundance pattern of HE 2252-4225 is in excellent agreement with the average abundance pattern of the strongly r-process enhanced stars CS 22892-052, CS 31082-001, HE 1219-0312, and HE 1523-091. This suggests a common origin of the first, second, and third r-process peak elements in HE 2252-4225 in the classical r-process. We tested the solar r-process pattern based on the most recent s-process calculations of Bisterzo et al. (2014) and found that elements in the range from Ba to Ir match it very well. No firm conclusion can be drawn about the relationship between the fisrt neutron-capture peak elements, Sr to Ru, in HE 2252-4225 and the solar r-process, due to the uncertainty in the solar r-process. The investigated star has an anomalously high Th/Eu abundance ratio, so that radioactive age dating results in a stellar age of tau = 1.5+-1.5 Gyr that is not expected for a very metal-poor halo star.
description: 20 pages, 6 tables, 9 figures, accepted for publication in A&A
เสื่อก๊กกับการส่งเสริมการท่องเที่ยวเชิงวัฒนธรรม จังหวัดบุรีรัมย์
Creators: name: ยโสธารา ศิริภาประภากร
Publisher: name: Department of Strategics for Improving Education Quality, Surindra Rajabhat University
Year: 2023
Subjects: ทรัพยากรการท่องเที่ยว
การท่องเที่ยวเชิงวัฒนธรรม
เสื่อก๊ก
จังหวัดบุรีรัมย์

description: วารสารราชภัฏสุรินทร์วิชาการ, 1, 5, 83-96
Additional file 1 of Immunotherapy in patients with metastatic castration-resistant prostate cancer: a meta-analysis of data from 7 phase III studies and 3 phase II studies
Creators: name: Zhang, Anqiang
name: Tong, Dali
Publisher: name: figshare
Year: 2022
Subjects: Medicine
Cancer

description: Additional file 1: The materials and methods section of meta-analysis including the descriptions of study outcome, inclusion and exclusion criteria, search strategy, study selection, data extraction and quality assessment and statistical analysis.
Phosphorylation of Threonine 61 by Cyclin A/Cdk1 Triggers Degradation of Stem-Loop Binding Protein at the End of S Phase
Creators: name: Graves, L. M.
name: Marzluff, W. F.
name: Koseoglu, M. M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2008

description: Histone mRNA levels are cell cycle regulated, and a major regulatory mechanism is restriction of stem-loop binding protein (SLBP) to S phase. Degradation of SLBP at the end of S phase results in cessation of histone mRNA biosynthesis, preventing accumulation of histone mRNA until SLBP is synthesized just before entry into the next S phase. Degradation of SLBP requires an SFTTP (58 to 62) and KRKL (95 to 98) sequence, which is a putative cyclin binding site. A fusion protein with the 58-amino-acid sequence of SLBP (amino acids 51 to 108) fused to glutathione S-transferase (GST) is sufficient to mimic SLBP degradation at late S phase. Using GST-SLBP fusion proteins as a substrate, we show that cyclin A/Cdk1 phosphorylates Thr61. Furthermore, knockdown of Cdk1 by RNA interference stabilizes SLBP at the end of S phase. Phosphorylation of Thr61 is necessary for subsequent phosphorylation of Thr60 by CK2 in vitro. Inhibitors of CK2 also prevent degradation of SLBP at the end of S phase. Thus, phosphorylation of Thr61 by cyclin A/Cdk1 primes phosphorylation of Thr60 by CK2 and is responsible for initiating SLBP degradation. We conclude that the increase in cyclin A/Cdk1 activity at the end of S phase triggers degradation of SLBP at S/G2.