title: Ð£ÑÐ°ÑÑÐ¸Ðµ Ð±ÐµÐ»ÐºÐ¾Ð²Ð¾Ð³Ð¾ ÑÐ°ÐºÑÐ¾ÑÐ° CHD1 Ð² ÑÐµÐ³ÑÐ»ÑÑÐ¸Ð¸ ÑÑÑÑÐºÑÑÑÑ Ñ ÑÐ¾Ð¼Ð¾ÑÐ¾Ð¼ Ð´ÑÐ¾Ð·Ð¾ÑÐ¸Ð»Ñ
title: Ð¼Ð°Ð³Ð¸ÑÑÐµÑÑÐºÐ°Ñ Ð´Ð¸ÑÑÐµÑÑÐ°ÑÐ¸Ñ
titleType: Subtitle
Creators: name: ÐÐ°ÑÐ°Ð½Ð¾Ð²ÑÐºÐ°Ñ, ÐÑÐ¸Ð½Ð°
Publisher: name: Ð¡Ð°Ð½ÐºÑ-ÐÐµÑÐµÑÐ±ÑÑÐ³ÑÐºÐ¸Ð¹ Ð¿Ð¾Ð»Ð¸ÑÐµÑÐ½Ð¸ÑÐµÑÐºÐ¸Ð¹ ÑÐ½Ð¸Ð²ÐµÑÑÐ¸ÑÐµÑ ÐÐµÑÑÐ° ÐÐµÐ»Ð¸ÐºÐ¾Ð³Ð¾
Year: 2016
Subjects: ÐÐ¾Ð»ÐµÐºÑÐ»ÑÑÐ½Ð°Ñ Ð±Ð¸Ð¾Ð»Ð¾Ð³Ð¸Ñ
ÐÐ»ÐµÑÐºÐ° (Ð±Ð¸Ð¾Ð»)
ÐÐµÐ»ÐºÐ¸
Ñ ÑÐ¾Ð¼Ð¾ÑÐ¾Ð¼Ñ
Ð³ÐµÐ½Ñ
Ð´Ð¾Ð·Ð¾Ð²Ð°Ñ ÐºÐ¾Ð¼Ð¿ÐµÐ½ÑÐ°ÑÐ¸Ñ
chromosome
genes
dosage compensation

description: ÐÐµÐ»Ð¾Ðº CHD1 ÑÐ²Ð»ÑÐµÑÑÑ ÐÐ¢Ð¤-Ð·Ð°Ð²Ð¸ÑÐ¸Ð¼ÑÐ¼ ÑÑÐ¾Ð¼Ð°ÑÐ¸Ð½-ÑÐµÐ¼Ð¾Ð´ÑÐ»Ð¸ÑÑÑÑÐ¸Ð¼ ÑÐ°ÐºÑÐ¾ÑÐ¾Ð¼, Ð¸Ð³ÑÐ°ÐµÑ ÐºÐ»ÑÑÐµÐ²ÑÑ ÑÐ¾Ð»Ñ Ð² ÑÐ±Ð¾ÑÐºÐµ Ð½ÑÐºÐ»ÐµÐ¾ÑÐ¾Ð¼, ÑÐ¾Ð´ÐµÑÐ¶Ð°ÑÐ¸Ñ Ð²Ð°ÑÐ¸Ð°Ð½ÑÐ½ÑÐ¹ Ð³Ð¸ÑÑÐ¾Ð½ H.3.3. ÐÑÐ¸ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð¸Ð¸ Ð¼Ð¾ÑÑÐ¾Ð»Ð¾Ð³Ð¸Ð¸ Ð¿Ð¾Ð»Ð¸ÑÐµÐ½Ð½ÑÑ ÑÑÐ¾Ð¼Ð¾ÑÐ¾Ð¼ Ð¾Ð±Ð½Ð°ÑÑÐ¶ÐµÐ½Ð¾ Ð¸Ð·Ð¼ÐµÐ½ÐµÐ½Ð¸Ðµ ÑÑÑÑÐºÑÑÑÑ Ð¥-ÑÑÐ¾Ð¼Ð¾ÑÐ¾Ð¼Ñ Ñ Ð½ÑÐ»Ñ-Ð¼ÑÑÐ°Ð½ÑÐ½ÑÑ Ð¿Ð¾ Ð³ÐµÐ½Ñ Chd1 ÑÐ°Ð¼ÑÐ¾Ð² Ð¸ ÑÑÐ°ÑÐ¸ÑÑÐ¸ÑÐµÑÐºÐ¸ Ð´Ð¾ÑÑÐ¾Ð²ÐµÑÐ½Ð¾Ðµ ÑÑÐ¸Ð»ÐµÐ½Ð¸Ðµ Ð´Ð°Ð½Ð½Ð¾Ð³Ð¾ ÑÑÑÐµÐºÑÐ° Ñ Ð¾ÑÐ¾Ð±ÐµÐ¹, Ð¼ÑÑÐ°Ð½ÑÐ½ÑÑ Ð¿Ð¾ Ð³ÐµÐ½Ñ Chd1 Ð¸ Ð¿Ð¾ Ð¾Ð´Ð½Ð¾Ð¼Ñ Ð¸Ð· Ð´Ð²ÑÑ Ð³ÐµÐ½Ð¾Ð², ÐºÐ¾Ð´Ð¸ÑÑÑÑÐ¸Ñ Ð²Ð°ÑÐ¸Ð°Ð½ÑÐ½ÑÐ¹ Ð³Ð¸ÑÑÐ¾Ð½ H3.3. ÐÐµÐ¾Ð±ÑÐ¾Ð´Ð¸Ð¼Ð¾ÑÑÑ Ð¿ÑÑÐ¼Ð¾Ð³Ð¾ Ð¿ÑÐ¸Ð²Ð»ÐµÑÐµÐ½Ð¸Ñ CHD1 Ðº Ð¥-ÑÑÐ¾Ð¼Ð¾ÑÐ¾Ð¼Ðµ ÑÐ°Ð¼ÑÐ¾Ð² Ð´Ð»Ñ Ð¿Ð¾Ð´Ð´ÐµÑÐ¶Ð°Ð½Ð¸Ñ ÐµÑ Ð½Ð¾ÑÐ¼Ð°Ð»ÑÐ½Ð¾Ð¹ ÑÑÑÑÐºÑÑÑÑ Ð¿Ð¾Ð´ÑÐ²ÐµÑÐ¶Ð´ÐµÐ½Ð° Ñ Ð¿Ð¾Ð¼Ð¾ÑÑÑ Ð¿Ð¾Ð´ÑÐ¾Ð´Ð°, Ð¾ÑÐ½Ð¾Ð²Ð°Ð½Ð½Ð¾Ð³Ð¾ Ð½Ð° Ð³Ð¸Ð¿ÐµÑÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð½ÐµÐ°ÐºÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð±ÐµÐ»ÐºÐ° Ð½Ð° ÑÐ¾Ð½Ðµ Ð´ÐµÐ»ÐµÑÐ¸Ð¸ Ð³ÐµÐ½Ð° Chd1. Ð¡ Ð¸ÑÐ¿Ð¾Ð»ÑÐ·Ð¾Ð²Ð°Ð½Ð¸ÐµÐ¼ Ð¼ÐµÑÐ¾Ð´Ð° ÐÐ¦Ð  Ð² ÑÐµÐ°Ð»ÑÐ½Ð¾Ð¼ Ð²ÑÐµÐ¼ÐµÐ½Ð¸ Ð¾Ð¿ÑÐµÐ´ÐµÐ»ÐµÐ½Ð° ÑÑÐµÐ´Ð½ÑÑ ÑÑÐµÐ¿ÐµÐ½Ñ Ð¿Ð¾Ð»Ð¸ÑÐµÐ½Ð¸Ð·Ð°ÑÐ¸Ð¸ ÑÑÐ´Ð° Ð³ÐµÑÐµÑÐ¾ÑÑÐ¾Ð¼Ð°ÑÐ¸Ð½Ð¾Ð²ÑÑ Ð³ÐµÐ½Ð¾Ð². ÐÐ¾ÐºÐ°Ð·Ð°Ð½Ð¾, ÑÑÐ¾ ÑÐ²ÐµÐ»Ð¸ÑÐµÐ½Ð¸Ðµ ÑÐ°Ð·Ð¼ÐµÑÐ° ÑÑÐ¾Ð¼Ð¾ÑÐµÐ½ÑÑÐ° Ð¿Ð¾Ð»Ð¸ÑÐµÐ½Ð½ÑÑ ÑÑÐ¾Ð¼Ð¾ÑÐ¾Ð¼ Ð¿ÑÐ¸ Ð³Ð¸Ð¿ÐµÑÑÐºÑÐ¿ÑÐµÑÑÐ¸Ð¸ Ð½Ð°ÑÐ¸Ð²Ð½Ð¾Ð³Ð¾ Ð±ÐµÐ»ÐºÐ° CHD1 Ð½Ðµ ÑÐ²ÑÐ·Ð°Ð½Ð¾ Ñ ÑÐ²ÐµÐ»Ð¸ÑÐµÐ½Ð¸ÐµÐ¼ ÑÐµÐ¿Ð»Ð¸ÐºÐ°ÑÐ¸Ð¸ Ð¸ÑÑÐ»ÐµÐ´Ð¾Ð²Ð°Ð½Ð½ÑÑ Ð³ÐµÑÐµÑÐ¾ÑÑÐ¾Ð¼Ð°ÑÐ¸Ð½Ð¾Ð²ÑÑ Ð³ÐµÐ½Ð¾Ð².
description: ATP-dependent chromatin remodeling enzymes play key role in nucleosome assembly and incorporation of variant histones into chromatin. CHD1 is the specific factor in the assembly of nucleosomes that contain variant histone H3.3. We have found that mutations in Drosophila Chd1 gene induce decondensation of male X chromosome. An effect of Chd1 null mutation can be increased by deficiency of one of the genes, encoding variant histone H3.3. Thus, the role of CHD1 in the control of male X chromosome organization can be mediated by CHD1 activity in H3.3 histone deposition and exchange. Using real-time PCR we have determined an average number of order polytenization of heterochromatic genes in polytene chromosomes in studied Drosophila lines. We have concluded that the increased size of chromocenter in polytene chromosomes of fruit flies with overexpression of native form of CHD1 isn't associated with increasing the replication level of the studied heterochromatic genes.