cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Design, construction, and in vivo feasibility of a positioning device for irradiation of mice brains using a clinical linear accelerator and intensity modulated radiation therapy
Creators: name: Rancilio, Nicholas J.
name: Dahl, Shaun
name: Athanasiadi, Ilektra
name: Perez-Torres, Carlos J.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Biotechnology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: Purpose: The goal of this study was to design a positioning device that would allow for selective irradiation of the mouse brain with a clinical linear accelerator. Methods: We designed and fabricated an immobilization fixture that incorporates three functions: head stabilizer (through ear bars and tooth bar), gaseous anesthesia delivery and scavenging, and tissue mimic/bolus. Cohorts of five mice were irradiated such that each mouse in the cohort received a unique dose between 1000 and 3000 cGy. DNA damage immunohistochemistry was used to validate an increase in biological effect as a function of radiation dose. Mice were then followed with hematoxylin and eosin (H&E) and anatomical magnetic resonance imaging (MRI). Results: There was evidence of DNA damage throughout the brain proportional to radiation dose. Radiation-induced damage at the prescribed doses, as depicted by H&E, appeared to be constrained to the white matter consistent with radiological observation in human patients. The severity of the damage correlated with the radiation dose as expected. Conclusions: We have designed and manufactured a device that allows us to selectively irradiate the mouse brain with a clinical linear accelerator. However, some off-target effects are possible with large prescription doses.
GROUNDWATER POTENTIAL INVESTIGATION OF UPPER DIDESSA RIVER CATCHMENT, WESTERN ETHIOPIA
Creators: name: DAWIT ITANA
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2020
Subjects: Upper Didessa catchment, Groundwater potential, Hydrochemistry, Water quality

description: This study aims to evaluate the groundwater potential of upper Didessa river catchment based on
 hydrometrological, hydrogeological, and hydrochemical data analysis. The study area is located in southern
 parts of Abay river basin and bounded between 707’- 901’N latitude and 360- 370E longitude. It is
 characterized by highly rugged topography, dendritic drainage pattern, and tropical to sub-tropical climate
 condition.
 By analyzing the available meteorological and river discharge data, the different water balance components
 of the study area was estimated using conventional approaches. The long-term mean annual precipitation
 over the study area is spatially variable but estimated to be 1725 mm and usually high rainfall is received
 during in winter months. The potential and actual evapotranspiration for the basin are 1177.6 mm and 1021
 mm, respectively. Similarly, surface runoff in the area was computed and found to be 330 mm/year. Finally,
 the long term annual recharge rate was calculated based on river discharge data (base flow separation) and
 water balance (residual) method. Accordingly, the recharge rate obtained from water balance method (374)
 mm/year) was believed to represent the annual groundwater recharge of the catchment.
 The groundwater potential of the study was evaluated using pump test analysis data, lithologic log
 interpretation, and nature of geology of the area. The hydraulic property vary spatially owing to difference
 in lithology and extent of weathering as well as fracturing. As a result, transmissivity vary from 0.3 m2/day
 to 566 m2/day. The fractured and weathered volcanic rocks are the main water bearing unit in the catchment.
 Generally, four hydrostratigraphic units was identified and were grouped in to four potential/productivity
 zones: high to moderate, moderate, low and very low potential zone.
 The hydrochemical analysis result shows that Ca and HCO3 are dominant cation and anion, respectively.
 Based on graphical plots, the major water type found to be Ca-Na-HCO3. The suitability of groundwater
 for drinking and agricultural purposes was evaluated by comparing with WHO water quality standard and
 different irrigation water quality indices (Na%, RSC, and SAR), respectably. Accordingly, water can serve
 for both domestic and irrigation without posing much risk with exception of a few water point.
Effects of formic acid, methanol and ethanol on the survival and detoxification immune-related gene expression in honeybees
Creators: name: Xiong, Ting
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 300304
subject: Animal protection (incl. pests and pathogens)
classificationCode: 300399
subject: Animal production not elsewhere classified

description: Formic acid, methanol and ethanol are widely used as pesticide adjuvants in pest control in agricultural production, but their effects on the health of Apis mellifera are rarely studied, and their effects on Apis cerana have not been reported so far. In order to investigate the effects of formic acid, methanol and ethanol on the survival rate of honeybees, and the effects of these reagents of 48h median lethal dose and 48h-LD50 on the mRNA expression of detoxification immune-related genes in honeybees, the effects of three chemical reagents on the survival rate of honeybees and 48h median lethal dose were determined by feeding methods. The effects of formic acid, methanol and ethanol at 48h-LD50 on the mRNA expression of detoxification immune-related genes in honeybees were studied by qRT-PCR. The results showed that the survival rate of honeybees in the experimental group was significantly lower than that in the control group.The mRNA expression of Cyp6as5, Cyp9e2, Defensin1 and PPO in the experimental groups was significantly different from that in the control group.This study provides evidence at the molecular level that median lethal dose of formic acid, methanol, and ethanol affect the physiology and metabolism of honeybees by disrupting the normal immune system of these insects, which is expecting to provide some theoretical basis for the maintenance of bee health.
Design, construction, and in-vivo feasibility of a positioning device for irradiation of mice brains using a clinical linear accelerator and intensity modulated radiation therapy
Creators: name: Rancilio, Nicholas J.
name: Dahl, Shaun
name: Athanasiadi, Ilektra
name: Perez-Torres, Carlos J.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Cell Biology
subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Biotechnology
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: Hematology

description: Purpose: The goal of this study was to design a positioning device that would allow for selective irradiation of the mouse brain with a clinical linear accelerator. Methods: We designed and fabricated an immobilization fixture that incorporates three functions: head stabilizer (through ear bars and tooth bar), gaseous anesthesia delivery and scavenging, and tissue mimic/bolus. Cohorts of five mice were irradiated such that each mouse in the cohort received a unique dose between 1000 and 3000 cGy. DNA damage immunohistochemistry was used to validate an increase in biological effect as a function of radiation dose. Mice were then followed with hematoxylin and eosin (H&E) and anatomical magnetic resonance imaging (MRI). Results: There was evidence of DNA damage throughout the brain proportional to radiation dose. Radiation-induced damage at the prescribed doses, as depicted by H&E, appeared to be constrained to the white matter consistent with radiological observation in human patients. The severity of the damage correlated with the radiation dose as expected. Conclusions: We have designed and manufactured a device that allows us to selectively irradiate the mouse brain with a clinical linear accelerator. However, some off-target effects are possible with large prescription doses.
Green synthesis of Gold Nanoparticles using Dovyalis abyssinica leave extract and its characterization and functional evaluation
Creators: name: Abera Beyene
Publisher: name: National Academic Digital Repository of Ethiopia
Year: 2020
Subjects: Dovyalis abyssinica, Green synthesis, Nanoparticles, antioxidant, Catalyst

description: n this work, gold nanoparticles (Au NPS) are synthesized using aqueous extract of
 Dovyalis abyssinica (D. abyssinica) leaf as reducing and surface capping agent. The
 phytochemical test of the crude extract showed the presence of tannins, phenolics,
 steroids, terpenes and saponins. HAuCl4 was successfully synthesized in the laboratory
 from pure gold and hydrochloric acid and then Au NPs were synthesized from HAuCl4
 and hydrochloric acid at 45 oC with a digestion time of 1 hr. The size of the particle was
 modulated by varying the ratio of the plant extract and HAuCl4 to obtain the smallest
 average particle size, 63.13 nm. To study the nature of reducing compounds, the crude
 water extract was fractionated with hexane and ethyl acetate sequentially. Based on the
 evaluation results, the aqueous fraction was the best reducing fraction to synthesize Au
 NPs. The SEM image of the synthesized Au NPs showed mixed shapes which are
 spherical, cylindrical rods and some irregularities. The synthesis of Au NPs was also
 confirmed by its characteristic crystalline peaks from X-ray diffraction (XRD) spectra.
 The FTIR spectrum revealed the presence of primary amines, cyanids, ether linkages
 sulfide bonds, and aromatic rings indicating the presence of proteins with more
 functional groups. The synthesized Au NPs showed excellent free radical scavenging
 potential against 2, 2-Diphenyl-2-picrylhydrazyl (DPPH) and catalytic activity for
 degradation of Bromothymol blue and methyl red. However, the newly synthesized Au
 NPs were not effective to inhibit the growth of selected bacteria (Staphylococcus aureus
 and E.coli).
New chemical constituents from the Piper betle Linn. (Piperaceae)
Creators: name: Atiya, Akhtar
name: Barij Nayan Sinha
name: Lal, Uma Ranjan
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: The phytochemical investigation of chloroform extract from Piper betle var. haldia, Piperaceae, leaves has resulted in the isolation of two new chemical constituents which were identified as 1-n-dodecanyloxy resorcinol (H1) and desmethylenesqualenyl deoxy-cepharadione-A (H4), on the basis of spectroscopic data 1D NMR (1H and 13C) and 2D NMR (1H-1H COSY and HMBC) as well as ESI-MS, FT-IR and HR-ESI-MS analyses. Compounds H1 and H4 showed excellent antioxidant DPPH free radical scavenging activity with IC50 values of 7.14 μg/mL and 8.08 μg/mL compared to ascorbic acid as a standard antioxidant drug with IC50 value of 2.52 μg/mL, respectively. Evaluation of cytotoxic activity against human hepatoma cell line (PLC-PRF-5) showed moderate effect with the GI50 values of 35.12 μg/mL for H1, 31.01 μg/mL for H4, compared to Doxorubicin® as a standard cytotoxic drug with GI50 value of 18.80 μg/mL.
title: ADCO, Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Cart. 188 (11 H 73), f. 0123r
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire

description: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Archives départementales de la Côte-d'Or, Cart. 188 (11 H 73), f. 0123r, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Cartulaire général de Cîteaux, dit de Jean de Cirey, (XVe siècle), tome IV, Archives départementales de la Côte-d'Or, Cart. 188 (11 H 73), f. 0123r, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https:// manuscrits.cbma-project.eu/
description: Provenance: abbaye de Cîteaux
description: Provenance: http://www.wikidata.org/entity/Q843261
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
The heliospheric current sheet at solar maximum
Creators: name: Child, Simon Roy
Publisher: name: Imperial College London
Year: 2020

description: Whilst near solar minimum it was possible to gain an understanding of the structure of the heliosphere in three dimensions using only low latitude in situ measurements, at solar maximum this was not the case. The Ulysses mission, with its unique almost polar orbit has provided an opportunity to investigate the structure of the heliosphere in three dimensions during a period of solar maximum. This thesis has focussed on investigating the topology and evolution of the HCS at solar maximum as well as the local structure of the boundary itself using magnetic field and plasma observations taken during the second Ulysses orbit. As a passive structure the Heliospheric Current Sheet (HCS) acts as a marker for the dynamic evolution of solar wind surrounding it while the large scale structure of the HCS also reflects the structure of the solar magnetic field. By combining simultaneous spacecraft observations at differing latitudes with potential field models the HCS was found to be near vertical at low latitudes and non planar at high latitudes. A second technique using minimum variance analysis to infer the orientation of the HCS concurred that the HCS extended to high latitudes, with the added suggestion that the topology was modified by stream interactions. Suprathermal electron heat flux measurements suggested the presence of substantial local HCS structure, especially during periods where the Ulysses trajectory skimmed along the HCS.
title: ADCO, Troisième cartulaire de Saint-Étienne de Dijon (XVIe), Cart. 23 (G 127), 310 folios, f. 00017
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2011
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Corpus Burgundiae Medii Aevi

description: Troisième cartulaire de Saint-Étienne de Dijon (XVIe), Archives départementales de la Côte-d'Or, Cart. 23 (G 127), 310 folios, f. 00017, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Troisième cartulaire de Saint-Étienne de Dijon (XVIe), Archives départementales de la Côte-d'Or, Cart. 23 (G 127), 310 folios, f. 00017, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
The effect of geometrical configurations on flows in idealised and realistic vascular geometries
Creators: name: Lee, Kyung Eun (Dana)
Publisher: name: Imperial College London
Year: 2020

description: This thesis reports the use of computational fluid dynamics (CFD) to investigate geometrical effects on flows in idealised non-branching double curved geometries (Study A) and in realistic distal anastomoses where geometries have been determined in vivo using magnetic resonance imaging (Study B). The purpose of this research is to improve understanding of the effects of geometrical configurations, especially curvature and non-planarity, on steady flow in idealised non-branching double curved geometries typical of arteries such as the aortic arch, the right coronary artery or the femoral arteries and on pulsatile flow in realistic distal anastomosis geometries. It is explained that the further knowledge gained from these idealised geometries can be useful to understand flows in anatomically correct geometries in order to optimise the design of end-to-side bypass graft vessels in clinical surgery. In the Study A, three-dimensional computations of steady flows in planar and non-planar double bends with 8 = 0.25 (curvature ratio) at Reynolds numbers of 125 and 500 were performed using the Navier-Stokes solver called Nektar that is based on spectral/hp element methods. The numerical haemodynamics analysis is presented in terms of the various mechanical factors which primarily involve axial velocity, transverse flows, vorticity, coherent vertical structure and wall shear stress. From these results, we can anticipate the wall shear stress distributions and secondary flow patterns in various double bend geometries with different non-planarity at low Reynolds numbers. Non-planarity plays a significant role on the wall shear stress distribution and the mixing properties of flow in the double bends, both of which are believed to be important factors for the patency of bypass grafts. In the Study B, Three sets of MRI data from patients undergoing tunnelled or superficial femoral bypass surgery were processed to give input velocity waveforms and geometries. From the latter and using the same Navier Stokes solver, detailed patient-specific pulsatile haemodynamics were calculated. Wall shear stress and velocity are influenced by the anatomical geometry, and wall shear stress distributions in pulsatile flow are compared with those in steady flow. The correlation is discussed between the haemodynamics and the remodelling of the vessel following bypass surgery determined in follow-up studies carried out a few months or a few years later. The results suggest that better designs should be possible for bypass grafts and indicate how inflow conditions can affect the flow field. The findings imply that proper anastomotical configurations might, induce haemodynamics environments that may prevent cardiovascular disorders or delay the progression of vascular disease.
The decarboxylative Ireland-claisen rearrangemet : methodology studies and approaches to the total synthesis of (-) -suaveoline
Creators: name: Lewis, Simon Eliot
Publisher: name: Imperial College London
Year: 2020

description: This thesis is divided into three sections. Section one is a review of recent progress in the synthesis of macroline, sarpagine and ajmaline-related indole alkaloids. The review covers approximately the last ten years of published literature. Section two is divided into two parts and discusses the results of research into the decarboxylative Ireland-Claisen rearrangement. Part one gives the background to the project and discusses the mechanism of this rearrangement. The development of methodology for the synthesis of bifunctional rearrangement substrates is detailed. The competitive rearrangement of these bifunctional substrates is outlined and trends in reactivity are discussed. An account is given of the application of the decarboxylative Ireland-Claisen rearrangement to a cyclic malonate, which gave rise to a cyclopropane. Efforts towards a cyclic malonate substrate are detailed, including the use of carbon suboxide. Part two concerns studies towards the total synthesis of (-)-suaveoline. The retrosynthetic analysis is explained and pertinent methodology introduced. The initial construction of a synthetically relevant rearrangement substrate is outlined. The reasons for the failure of this substrate to rearrange are discussed, as is the modified protecting group strategy that was adopted. Subsequent successful rearrangement and the synthesis of a key cyclopentenyl intermediate are described. Unsuccessful attempts to alkylate this cyclopentene are detailed and an alternative strategy is put forward. Novel methodology for the formation of pyridine-A/-oxides is disclosed and attempts to apply this to the synthesis of suaveoline are discussed. Section three is the experimental section, which gives detailed descriptions of the synthesis and spectroscopic characteristics of the compounds discussed in section two.
Three-dimensional wake dynamics of curved cylinders
Creators: name: Miliou, Anthi
Publisher: name: Imperial College London
Year: 2020

description: Three-dimensional computations have been performed in order to study the fundamental mechanisms of vortex shedding past curved circular cylinders in directions normal and parallel to the plane of curvature at Reynolds numbers of 100 and 500. The basic shape upon which all the geometries were built was that of a quarter ring. The spatial discretization of the three-dimensional Navier-Stokes algorithm was based on the spectral//ip element method. For the cases where the flow was normal to the plane of curvature, a quarter ring geometry and a curved cylinder ending semi-buried in the ground were studied. Different flow conditions were applied including a uniform or sheared velocity profile and a slip or a no-slip wall. The effect of a sheared velocity profile was found to be dominant to that of the wall boundary and resulted in vortex linking and lack of correlation along the span. For the cases where the flow was parallel to the plane of curvature, different configurations were investigated with respect to the leading edge orientation. When the flow was directed onto the outside of the bend, three-dimensional shedding was observed not governed by the variation of local normal Reynolds numbers considered by a sectional approach. With the free-stream aligned onto the inside of the bend, however, no conventional shedding was detected. The axial flow directed towards the top of the geometry and the production of streamwise vorticity played a key role in stabilizing the wake. The steady wake features persisted on the whole even when a straight cylinder extension was added on top of the curved body. The feeding of the axial flow, stemming from the curved part, into the straight cylinder extension, weakened the shedding process expected from a straight cylinder at these Reynolds numbers. Maximum w velocity components of the order of the free-stream at Re = 500 were located in the wakes of these bodies. Experimental work was also conducted alongside. The towing tank flow visualizations were found to be in qualitative agreement with the computational findings. Overall, the importance of investigating these curved cylinder flows with a fully three-dimensional approach has been demonstrated, especially for the second set of computations.
Pew Research Center: Voting and Citizenship April 2017 Survey
Creators: name: Pew Research Center
Publisher: name: Roper Center for Public Opinion Research
Year: 2020

description: Citizens should have to prove they want to vote by registering ahead of time vs. make it easy to vote (1); citizens required to vote in national elections (1); give up personal privacy to keep country safe (1); government restrictions on private property (1); gap between rich and poor a threat to American democracy (1); jury duty (1); registered to vote (1).
Changes in hepatic phase I and phase II biotransformation enzyme expression and glutathione levels following atrazine exposure in female rats
Creators: name: Zimmerman, Arthur D.
name: Breckenridge, Charles B.
name: Yi, Kun D.
name: Pragati Sawhney Coder
name: Wanders, Desiree
name: Judd, Robert L.
name: Foradori, Chad D.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Physiology
subject: Pharmacology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Plant Biology
subject: 60506 Virology

description: 1. To determine the effects of repeated atrazine (ATR) treatment on hepatic phase I and II enzymes, adult female rats were treated with vehicle or 100 mg/kg of ATR for 1, 2, 3 or 4 days. Glutathione-s-transferases (GST) mRNA expression, protein levels (mu, pi, alpha, omega), and activity (cytosolic and microsomal), along with bioavailable glutathione (GSH) were assayed. 2. GST expression, concentrations and activity were increased, along with GSH levels, in animals treated with ATR for 3 and 4 days. 3. A subsequent study was performed with animals treated with vehicle, 6.5, 50 or 100 mg/kg/day for 4, 8 or 14 days. Expression of hepatic phase I CYP 450 enzymes was evaluated in conjugation with GST expression, protein and activity. Nineteen of the 45 CYP enzymes assayed displayed increased mRNA levels after eight days of treatment in animals treated with 50 or 100 mg/kg/day. After 14 days of treatment, all CYP expression levels returned to control levels except for CYP2B2, CYP2B3, CYP2C7, CYP2C23, CYP2E1, CYP3A9, CYP4A3 and CYP27A1, which remained elevated. 4. Results indicate that there may be a habituation or adaptation of liver phase I and phase II expression following repeated ATR treatment.
Risk of serious opportunistic infections after solid organ transplantation: interleukin-2 receptor antagonists versus polyclonal antibodies. A meta-analysis
Creators: name: Kalil, Andre C
name: Florescu, Marius C
name: Grant, Wendy
name: Miles, Clifford
name: Morris, Michael
name: R Brian Stevens
name: Langnas, Alan N
name: Florescu, Diana F
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Cell Biology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: 60506 Virology
subject: Cardiology

description: Background: We aimed to evaluate and quantify the risk of serious opportunistic infections after induction with polyclonal antibodies versus IL-2 receptor antagonists (IL-2RAs) in randomized clinical trials. Methods: PRISMA guidelines were followed and random-effects models were performed. Results: 70 randomized clinical trials (10,106 patients) were selected: 36 polyclonal antibodies (n = 3377), and 34 IL-2RAs (n = 6729). Compared to controls, polyclonal antibodies showed higher risk of serious opportunistic infections (OR: 1.93, 95% CI: 1.34–2.80; p < 0.0001); IL-2RAs were associated with lower risk of serious opportunistic infections (OR: 0.80, 95% CI: 0.68–0.94; p = 0.009). Polyclonal antibodies were associated with higher risk of bacterial (OR: 1.58, 95% CI: 1.00–2.50; p = 0.049) and viral infections (OR: 2.37, 95% CI: 1.60–3.49; p < 0.0001), while IL-2RAs were associated with lower risk of cytomegalovirus (CMV) disease (OR: 0.73, 95% CI: 0.56–0.97; p = 0.032). Adjusted indirect comparison: compared to polyclonal antibodies, IL-2RAs were associated with lower risk of serious opportunistic infections (OR: 0.41, 95% CI: 0.34–0.49; p < 0.0001), bacterial infections (OR: 0.51, 95% CI: 0.39–0.67; p < 0.0001) and CMV disease (OR: 0.58, 95% CI: 0.34–0.98; p = 0.043). Results remained consistent across allografts. Conclusion: The risk of serious opportunistic infections, bacterial infections and CMV disease were all significantly decreased with IL-2RAs compared to polyclonal antibodies.
title: ADCO, Huitième cartulaire de Saint-Étienne de Dijon (1661-1667), Cart. 31 (G 135), 549 folios, f. 0978
Creators: name: de la Côte d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: cartulaire
subject: LaMOP
subject: Corpus Burgundiae Medii Aevi
subject: Laboratoire de Médiévistique Occidentale de Paris
subject: Chartes de la Bourgogne du Moyen Âge

description: Huitième cartulaire de Saint-Étienne de Dijon (1661-1667), Archives départementales de la Côte-d'Or, Cart. 31 (G 135), 549 folios, f. 0978, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Huitième cartulaire de Saint-Étienne de Dijon (1661-1667), Archives départementales de la Côte-d'Or, Cart. 31 (G 135), 549 folios, f. 0978, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Relationship between voided volume and the urge to void among patients with lower urinary tract symptoms
Creators: name: Blaivas, Jerry G.
name: Tsui, Johnson F.
name: Amirian, Michael
name: Buddima Ranasinghe
name: Weiss, Jeffrey P.
name: Haukka, Jari
name: Tikkinen, Kari A. O.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 110309 Infectious Diseases

description: Objective.The aim of this study was to explore the relationship between voided volume (VV) and urge to void among patients with lower urinary tract symptoms. Material and methods. Consecutive adult patients (aged 23–90 years) were enrolled, and completed a 24 h bladder diary and the Urgency Perception Scale (UPS). Patients were categorized as urgency or non-urgency based on the Overactive Bladder Symptom Score. The relationship between UPS and VV (based on the bladder diary) was analyzed by Spearman’s rho and proportional odds model. Results. In total, 1265 micturitions were evaluated in 117 individuals (41 men, 76 women; 56 individuals in the urgency and 61 in the non-urgency group). The mean (± SD) VV and UPS were 192 ± 127 ml and 2.4 ± 1.2 ml in the urgency group and 173 ± 124 ml and 1.7 ± 1.1 ml in the non-urgency group, respectively. Spearman’s rho (between UPS and VV) was 0.21 [95% confidence interval (CI) 0.13–029, p < 0.001] for the urgency group, 0.32 (95% CI 0.25–0.39, p < 0.001) for the non-urgency group, and 0.28 (95% CI 0.23–0.33, p < 0.001) for the total cohort. Urgency patients had higher UPS [odds ratio (OR) 3.1, 95% CI 2.5–3.8]. Overall, each additional 50 ml VV increased the odds of having a higher UPS with OR 1.2 (95% CI 1.2–1.3). The relationship between VV and UPS score was similar in both groups (p = 0.548 for interaction). Conclusion. Although urgency patients void with a higher UPS score, among both urgency and non-urgency patients there is only a weak correlation between VV and the urge to void. This suggests that there are factors other than VV that cause the urge to void.
Comparison of intermittent and continuous androgen deprivation and quality of life between patients with locally advanced and patients with metastatic prostate cancer: a post hoc analysis of the randomized FinnProstate Study VII
Creators: name: Salonen, Arto J.
name: Taari, Kimmo
name: Ala-Opas, Martti
name: Sankila, Anna
name: Viitanen, Jouko
name: Lundstedt, Seppo
name: Tammela, Teuvo L. J.
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: 111714 Mental Health
subject: FOS: Health sciences
subject: 60506 Virology

description: Objective. The aim of the study was to compare intermittent (IAD) and continuous (CAD) androgen deprivation therapy (ADT) between locally advanced (M0) and metastatic (M1) prostate cancer, and the effect of ADT on the quality of life. Material and methods. In total, 852 men with advanced prostate cancer were enrolled to receive goserelin acetate for 24 weeks. Of these, 554 patients whose prostate-specific antigen (PSA) decreased to less than 10 ng/ml or by at least 50% (<20 ng/ml at baseline) were randomized to IAD or CAD. In the IAD arm, ADT was resumed for at least 24 weeks whenever PSA increased to greater than 20 ng/ml or above baseline. Results. Median follow-up time was 65 months. Median times from randomization to progression, death, prostate cancer death and treatment failure in M0 and M1 patients were 46.8 and 21.4, 57.6 and 40.3, 59.5 and 40.7, and 41.9 and 20.0 months, respectively (p < 0.001). No significant differences emerged between IAD and CAD. ADT showed a beneficial effect on pain, activity limitation and social functioning in M1 patients, and a deleterious effect on physical capacity in M0 patients and on sexual functioning in both groups. IAD offered extra benefit for activity limitation, social functioning and recovery of sexual functioning. Conclusions. IAD is as efficient as CAD in treatment of locally advanced and metastatic prostate cancer. ADT improves quality of life in M1 patients, with IAD offering extra benefit.
Laser Offset Stabilization for Broadly Tunable TeraHertz (THz) Frequency Generation
Creators: name: Cossel, Kevin
Publisher: name: California Institute of Technology
Year: 2007
Subjects: Chemistry and Physics
Chemistry
Physics

description: Spectroscopy and imaging in the terahertz region promises to be useful for a wide variety of applications. For remote sensing, terahertz spectroscopy could help in the identification of explosives and narcotics. In astronomy, terahertz imaging should provide new information about the composition of the interstellar medium and about the processes by which stars and planets are born. In chemistry and molecular biology, terahertz spectroscopy provides new rotational or rovibrational spectra of molecules and is useful in the study of hydrogen-bound clusters that serve as model systems for the quantitative understanding of the intermolecular forces involved in (bio )polymers and aqueous media. However, there are currently no terahertz sources that are easily tunable over the full region with high precision and accuracy. Here, we discuss the development of a novel three-laser source that allows for accurate stabilization of the difference frequency between two diode lasers to any frequency up to several terahertz, while still maintaining a long-term linewidth of under 10 MHz. When coupled with new traveling-wave photomixers, we will have a narrow linewidth, broadband terahertz source with high accuracy and capable of delivering up to tens of microwatts of power.
Progress toward the Development of a Single Molecule Transistor with Graphene Electrodes
Creators: name: Schmidgall, Emma Rose
Publisher: name: California Institute of Technology
Year: 2007
Subjects: Physics and History
Physics

description: Single molecule transistors are useful for studying both the charge and spin states of molecules. These devices consist of a nanogap with three contacts for the source, drain, and gate. Current versions use metallic contacts for the source and drain, which remain essentially three dimensional. It is thought that graphene contacts for the source and drain, which would he atomically tlat, would enable the observation of more molecular charge states due to reduced screening between the sample and the contacts. This thesis presents the progress made in the development of graphene single molecule transistors during the 2006-2007 academic year. Additionally, this thesis will introduce a new method for the large-scale production of graphene samples.
The influence of coercive measures on patients’ stances towards psychiatric institutions
Creators: name: Mielau, Juliane
name: Altunbay, Jasmin
name: Lehmann, Anja
name: Bermpohl, Felix
name: Heinz, Andreas
name: Montag, Christiane
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Cell Biology
subject: Neuroscience
subject: Science Policy
subject: 111714 Mental Health
subject: FOS: Health sciences

description: Objective: To examine the impact of coercive interventions (CI) on patients’ evaluations of psychiatric hospitals as adversaries versus allies. Methods: Self-constructed interviews were conducted relating to quantitative and subjective aspects of coercion and the attitude towards psychiatry of 79 patients with psychotic and bipolar disorders. The Coercion Experience Scale (CES) and the Admission Experience Survey (AES) were used to establish the subjective impact of CI. Instruments measuring psychopathological symptoms and the Global Assessment of Functioning (GAF) were applied alongside the Schedule for the Assessment of Illness (SAI) and the Beck Cognitive Insight Scale (BCIS). Using a logistic regression approach, considered influencing factors such as number, type and patients’ subjective experiences of CI, cognitive and clinical insight, psychopathological symptoms and patients' global perceptions of their hospitalisation were analysed for their predictive value of patients’ attitudes towards psychiatry. Results: Binary logistic regression revealed that the subjective experience of CI and the perception of fairness and effectiveness during the treatment process predict patients’ attitudes towards psychiatry to a greater extent than symptom-related measures or the quantity of CI. Patients presenting a higher degree of self-reflectiveness perceive psychiatric institutions more likely as allies. Conclusions: The manner in which coercion is subjectively experienced has direct influence on patients’ perceptions of psychiatry.
Opening the Red Budget Box: Nonlinear Effects of a Tax Shock in the UK
Creators: name: Colombo, Valentina
Publisher: name: Alma Mater Studiorum - Università di Bologna
Year: 2020
Subjects: SECS-P/01 Economia politica

description: This paper studies the real effects of an exogenous UK tax change in recessions and expansions. The tax shock is identified via the measure proposed by Cloyne (2013). Combining local projection techniques (Jordà, 2005) with smooth transition regressions (Granger and Teräsvirta, 1994), tax policy shock is found to affect UK macroeconomic variables depending on the phase of the business cycle the economy is when tax shock occurs. An exogenous tax cut in recessions triggers a large, persistent, positive, and statistically significant reaction in output, consumption, investment, exports, imports, and government consumption. The results suggest that the output tax multiplier is positive and above one (in absolute value) in recessions but not in expansions. The size and the sign of responses of a number of macroeconomic variables are also found to be state-contingent.
Orbital atherectomy for the treatment of severely calcified coronary lesions: evidence, technique, and best practices
Creators: name: Shlofmitz, Evan
name: Martinsen, Brad J.
name: Lee, Michael
name: Rao, Sunil V.
name: Généreux, Philippe
name: Higgins, Joe
name: Chambers, Jeffrey W.
name: Kirtane, Ajay J.
name: Brilakis, Emmanouil S.
name: Kandzari, David E.
name: Sharma, Samin K.
name: Shlofmitz, Richard
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Medicine
subject: Cell Biology
subject: Molecular Biology
subject: Physiology
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Cancer
subject: Science Policy
subject: Hematology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Introduction: The presence of severe coronary artery calcification is associated with higher rates of angiographic complications during percutaneous coronary intervention (PCI), as well as higher major adverse cardiac events compared with non-calcified lesions. Incorporating orbital atherectomy (OAS) for effective preparation of severely calcified lesions can help maximize the benefits of PCI by attaining maximal luminal gain (or stent expansion) and improve long-term outcomes (by reducing need for revascularization). Areas covered: In this manuscript, the prevalence, risk factors, and impact of coronary artery calcification on PCI are reviewed. Based on current data and experience, the authors review orbital atherectomy technique and best practices to optimize lesion preparation. Expert Commentary: The coronary OAS is the only device approved for use in the U.S. as a treatment for de novo, severely calcified coronary lesions to facilitate stent delivery. Advantages of the device include its ease of use and a mechanism of action that treats bi-directionally, allowing for continuous blood flow during treatment, minimizing heat damage, slow flow, and subsequent need for revascularization. The OAS technique tips reviewed in this article will help inform interventional cardiologists treating patients with severely calcified lesions.
Latihan Pemodelan Sederhana Metode Induced Polarization
Creators: name: Heriyanto, Mohammad
Publisher: name: figshare
Year: 2017
Subjects: subject: 40401 Electrical and Electromagnetic Methods in Geophysics
subject: FOS: Earth and related environmental sciences

description: Latihan pemodelan induced polarization sederhana untuk kasus silinder horisontal.
Tetrazoleacetic acid templated 3d-4f heterometallic-organic frameworks constructed from different ligands: structures, luminescence, magnetism and photocatalytic properties
Creators: name: Zhou, Lin-Xia
name: Xu, Jian-Qing
name: Zheng, Yue-Qing
name: Zhu, Hong-Lin
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Medicine
subject: Molecular Biology
subject: Biotechnology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: FOS: Biological sciences
subject: 69999 Biological Sciences not elsewhere classified

description: A series of 3-D lanthanide-transition 3d-4f heterometallic complexes have been synthesized by hydrothermal route from mixtures of 2,2′-bipyridyl-5,5′-dicarboxylic acid (H2bpdc) and acetic acid (HAc) with tetrazoleacetic acid as template. The single-crystal X-ray analysis shows that nine CdLn(H2O)2Cl2(bpdc)Ac complexes (Ln = La for 1, Pr for 2, Nd for 3, Sm for 4, Eu for 5, Gd for 6, Dy for 7, Ho for 8, Er for 9) crystallized in the space group P-1 and featured three-nodal (3, 4, 6)-three connected topological frameworks. The photocatalytic behaviors imply that 1–9 have significant photocatalytic activities for degradation of RhB.
Characterization and physicochemical studies of the conjugates of graphene quantum dots with differently charged zinc phthalocyanines
Creators: name: Refilwe Matshitse
name: Kutloano E. Sekhosana
name: Ojodomo J. Achadu
name: Tebello Nyokong
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Biophysics
subject: Biochemistry
subject: Space Science
subject: 29999 Physical Sciences not elsewhere classified
subject: FOS: Physical sciences
subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Plant Biology

description: Unsubstituted zinc phthalocyanine (ZnPc), 2,9,16,23-tetrakis[4-(N-methylpyridyloxy)]-phthalocyanine (ZnTPPcQ) and Zn tetrasulfo phthalocyanine (ZnTSPc) were non-covalently (electrostatic and/or π–π interaction) attached to graphene quantum dots (GQDs) to form GQDs-Pc nanoconjugates. Relative to Pcs alone, the presence of GQDs improved the triplet quantum yields with the following values: GQDs-ZnPc (0.73), GQDs-ZnTPPcQ (0.76) and GQDs-ZnTSPc (0.67). Respective Förster resonance energy transfer (FRET) efficiencies were calculated to be 0.81, 0.80 and 0.28. However, singlet oxygen generating abilities of the as-synthesized nanoconjugates were relatively low due to the screening effect of GQDs and quenching in water. This study shows that, the type of Pc, loading and solvent used are among the vital properties to consider when constructing GQD-nanoconjugate systems with optimal triplet quantum yield properties and investigation of their physicochemical properties.
title: ADCO, Sixième cartulaire de Saint-Étienne de Dijon (1662), Cart. 30 (G 133), 441 folios, f. 815
Creators: name: de la Côte d'Or, Archives départementales
name: Petot, Frédéric
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CG21/F.PETOT/2012
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: cartulaire
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Sixième cartulaire de Saint-Étienne de Dijon (1662), Archives départementales de la Côte-d'Or, Cart. 30 (G 133), 441 folios, f. 815, Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Sixième cartulaire de Saint-Étienne de Dijon (1662), Archives départementales de la Côte-d'Or, Cart. 30 (G 133), 441 folios, f. 815, in Projet CBMA - Corpus Burgundiae Medii Aevi [Ressource en ligne], https://manuscrits.cbma-project.eu/
description: Provenance: abbaye Saint-Étienne de Dijon
description: Provenance: http://www.wikidata.org/entity/Q15945019
Stage finishes – mapping the locations and results of Tour de France (1903–2016)
Creators: name: Bačík, Vladimír
name: Klobučník, Michal
Publisher: name: Taylor & Francis
Year: 2017
Subjects: subject: Physiology
subject: FOS: Biological sciences
subject: Evolutionary Biology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Developmental Biology
subject: Inorganic Chemistry
subject: Science Policy
subject: Plant Biology

description: The aim of this paper is to illustrate the history of one of the world's greatest multi-stage bicycle races, the Tour de France, by mapping all the stage finish places from the first race in 1903 to the present. On the one hand, there is a long list of places that the Tour de France has visited just once in its whole history, but on the other, there are also several places that different editions include fairly regularly. Since the Tour de France is one of the most watched sports events on the planet, spatial variability is a good means for promoting the different regions of France and the surrounding countries where individual stages have been held. The organisation of individual editions does not depend on the existence of purpose-built sports stadiums but makes use of the existing infrastructure and settlement structure that have developed over long periods. By showing the finish places, we are able to capture not only the frequency of the inclusion of the places in the race, but also show the success of cyclists from different countries at each stage finish and thus identify the countries that have historically been most successful at winning stages.