cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Whole-genome DNA methylation profiling of pancreatic cancer using bisulfite sequencing
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Pancreatic cancer is the fourth leading cause of cancer death in the United States with a dismal overall five-year survival rate of less than 5%. In spite of significant headway in determining the major genetic and epigenetic alterations that contribute to pancreatic carcinogenesis, there have been no significant advances in our treatment of this highly aggressive and lethal disease. A more comprehensive picture of the full range of genetic and epigenetic changes is needed to better inform the development of new pancreatic cancer diagnostic and therapy. Epigenetic alterations including changes in DNA methylation have been recognized in recent years as key factor in the development of cancer. Genome-wide screenings of DNA-methylation patterns reveals a great potential to identify tumour-suppressor genes, and more importantly to detect disease markers for the early detection of cancer. My laboratory at UCLA has recently developed methods for coupling genomic bisulfite sequencing with ultra high throughput DNA sequencing methods for determining DNA methylation patterns at single nucleotide resolution. This approach, termed BS-Seq, unlike previous microarray-based methods, allows one to sensitively measure methylation on a genome-wide scale and thus understand the specific sequence contexts associated with methylation. This proposal is to provide the first comprehensive profile of molecular alterations in pancreatic cancer by performing parallel high resolution mapping of both the pancreatic cancer epigenome and transcriptome. The aims of this proposal are: 1) To generate a reference map of DNA methylation and mRNA at single nucleotide resolution for normal human pancreatic ductal epithelium. 2) To identify alterations in the global transcriptome and DNA methylome at single nucleotide resolution in human pancreatic adenocarcinoma. Identifying the full complement of genetic and epigenetic alterations that occur in pancreatic cancer will improve our understanding of the molecular basis of pancreatic adenocarcinoma with the potential to uncover (i) novel targets for therapeutic intervention, (ii) new early cancer detection markers and (iii) better predictors of response to therapy.
Conus (Turriconus) miniexcelsus
Creators: name: Tenorio, Manuel J.
name: Puillandre, Nicolas
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Neogastropoda
Conidae
Conus
Conus miniexcelsus

description: Conus (Turriconus) miniexcelsus (Olivera & Biggs, 2010)
Figs 2, 87I–K, N
Conus miniexcelsus Olivera & Biggs in Biggs et al., 2010: 5, figs 1–2, 4, 6, 8.
Turriconus miniexcelsus – Tucker & Tenorio 2013: 281.
Turriconus (Turriconus) miniexcelsus – Monnier et al. 2018a: 340.
Material examined
2 lots (2 specimens). See Supp. file 1.
Type material
Holotype PHILIPPINES • 22 mm; Aliguay Island; 30–150 m depth; Marine Science Institute of the University of the Philippines (Fig. 87I).
Figured material
NEW CALEDONIA • 22 mm; Norfolk Ridge, Munida, off New Caledonia, stn DW3106; 23°02′ S, 168°21′ E; 180–220 m depth; 27 Oct. 2008; TERRASSES expedition; MNHN (Fig. 87J, N) • 32.3 mm; S Lansdowne, off New Caledonia, stn DW2639; 20º47′ S, 161º01′ E; 289‒294 m depth; 22 Oct. 2005; EBISCO expedition; MNHN (Fig. 87K).
Geographical distribution and bathymetry
Japan (Ryu Kyu Islands) to the Philippines and Vietnam (Monnier et al. 2018a). Also present in Papua New Guinea, Solomon Islands and New Caledonia, where this species has been sampled in Coral Sea and Norfolk Ridge at depths between 180‒ 294 m.
Remarks
Shell moderately small (maximum shell length 37 mm), biconical with a high spire of straight profile. Protoconch multispiral of about 3 whorls. Last whorl with flat spiral ribbons, white with two brown spiral bands, and a pattern of little brown square or rectangular spots. Radular tooth (Fig. 87N) with the anterior section much shorter than the posterior section. Tooth serrated with 4–5 small denticles arranged in one row, ending on a large, pointed cusp. Barb indistinct. Blade reduced or absent. Very small basal spur present on the rounded base. This species, resembling in shape a small specimen of C. (T.) excelsus (and hence its name), was initially reported from the Philippines, and its range has now been extended to many other localities including New Caledonia. It is distinct from C. (T.) excelsus as shown in the DNA phylogeny (Fig. 2), where one specimen from New Caledonia appears sister to another one from Papua New Guinea.
description: Published as part of Tenorio, Manuel J. & Puillandre, Nicolas, 2023, Revision of the deep-water cone snail fauna from New Caledonia (Gastropoda, Conoidea), pp. 1-134 in European Journal of Taxonomy 896 on page 122, DOI: 10.5852/ejt.2023.896.2291, http://zenodo.org/record/8405510
Efficacy of chlorine dioxide gas in inactivating salmonella spp. on mung beans sprouts
Creators: name: Prodduk, Vara
Publisher: name: No Publisher Supplied
Year: 2013

description: Rising popularity of fresh sprouted beans and grains as a source of good nutrition also brings increased challenges for maintaining food safety and quality. Internalization of various microorganisms apart from surface localization is a hurdle in ensuring safe produce of high quality. Microorganisms internalized in stomata and crevices may not be affected by the traditional chlorine sanitizing wash treatment. Sprouts, integral to many cuisines, have been the focus of media attention due to the frequency and severity of microbial outbreaks. Sprouts provide good matrices for microbial localization and growth due to optimal conditions of temperature and humidity while sprouting and lack of post-processing. In fact, the microbial populations on sprouts are some of the largest reported for fresh produce.  As conventional aqueous chlorine sanitizing wash treatment was unable to provide more than 2 log10 CFU/gram reduction in Salmonella spp. levels, this research explores the antimicrobial effectiveness of gaseous chlorine dioxide on mung bean sprouts. 3 – 4 log CFU/gram reduction was achieved in Salmonella serovar inoculated sprouts by gaseous chlorine dioxide application at various time combinations.  The difference in microbial reduction points to the important role of surface physiology, pore structure and bacterial internalization in sprouts. Consequently, the surface morphology of sprouts has been studied to understand the better efficacy of gaseous antimicrobial chlorine dioxide.   As the microbial loads and microorganism distribution on sprouts is variable, a three-dimensional printer was utilized to design and create consistent reliable silicone substrates which can simulate the surface physiology and pore structure of sprouts.  Sprouts have a complex farm-to-fork path with multiple microbial contamination scenarios. This research helps understand how gaseous antimicrobials and increase in surface area available for antimicrobial application can provide more effective microbial load reduction.
Understanding sex change in exploited fish populations
Creators: name: Provost, Mikaela M.
Publisher: name: No Publisher Supplied
Year: 2013

description: Hermaphroditic species present unique challenges to fishery managers because the effects of fishing on hermaphroditic population dynamics are not entirely understood. In protogynous hermaphrodites (female to male sex change) the sex ratio varies with size as females change to males. It is expected that male fish have disproportionately high fishing mortality in size regulated fisheries for two reasons. First, males are predicted to be more vulnerable to fishing because they are larger than females and, second, male fish often exhibit aggressive behavior. The implications of prolonged fishing pressure on the population dynamics of protogynous hermaphrodites varies across species. More information about species’ patterns of sex change is needed in order to understand the effects of fishing.  This study is divided into two separate chapters: (1) review how sex change is currently handled in stock assessments along the eastern coast of the U.S. in order to identify key data gaps, and to compare hermaphroditic and gonochoristic stock status. (2) Using a tagging study, measure sex selectivity and sex change as a function of size, age, and season in black sea bass (Centropristis striata), an economically important protogynous hermaphrodite in New Jersey and along the East Coast.   A review of eleven hermaphroditic stock assessments revealed that sex change is handled in a variety of ways. Despite that no stock assessments assessed sex-specific mortality; hermaphroditic stock status was not any worse off than gonochoristic stock status. In black sea bass, the vulnerability of capturing males and females varied by size and between commercial and recreational fishing gears. For commercial traps, males of intermediate size range (280–360 mm) were most likely to be captured, probability ranged 0.0&–0.12. For recreational hook-and-line, male vulnerability increased with size: the largest males (440–500 mm) had the highest change of being captured, probability ranged 0.30–0.60.  Across most sizes (129–483 mm), commercial traps captured a significantly higher proportion of males at length compared to hook-and-line fishing gear. Size at 50% sex change was 365 mm and all sex changing females were 3–4 years old. Females that changed sex ranged from 290–3&0 mm to 342–480 mm. Complete sex change events happened over the winter between the summer spawning seasons in 2011 and 2012, it was expected that slightly less than half (4&%) of female black sea bass in 2011 changed sex by the following year in 2012.
Additional file 2: of Lactoferrin and lysozyme to reduce environmental enteric dysfunction and stunting in Malawian children: study protocol for a randomized controlled trial
Creators: name: Cheng, William
name: Wold, Karl
name: Benzoni, Nicole
name: Thakwalakwa, Chrissie
name: Maleta, Kenneth
name: Manary, Mark
name: Indi Trehan
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Assessment of the change in environmental enteropathy after supplementation with bovine lactoferrin and recombinant human lysozyme. (PDF 1177 kb)
Astyanax belizianus Bocourt 1868
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Characiformes
Characidae
Astyanax
Astyanax belizianus

description: Astyanax belizianus Bocourt 1868. Belizean Tetra; Sardina, Sardina de Río, Sardinilla, Sabalete, Sábalo, Sardina Común, Plateada, Machaca, Coliroja, Picaculo, Golosa, Tetra, Mojarra, Sardina De Belize
Vouchers: Not available. Distribution: Central America; from southern Belize and eastern Guatemala to eastern Honduras-northern Nicaragua, Atlantic drainages; (Nicaragua) Co (Atlantic); 4–31 masl; Pri, Pot. Occurrence and conservation status: Nat; NE, population trend unknown. Literature: Schmitter-Soto (2017: 37; redescription, including illustrations and an identification key, and information on distribution, with a map, and ecology).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 22, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
IRENA and IEECP Joint Workshop: Stakeholder-driven energy scenarios for a just transition: Dialogue with the scientific community
Creators: name: Süsser, Diana
name: Goussous, Nadeem
Publisher: name: Zenodo
Year: 2024

description: SSH CENTRE (Social Sciences and Humanities for Climate, Energy aNd Transport Research Excellence) is a Horizon Europe project, engaging directly with stakeholders across research, policy, and business (including citizens) to strengthen social innovation, SSH-STEM collaboration, transdisciplinary policy advice, inclusive engagement, and SSH communities across Europe, accelerating the EU’s transition to carbon neutrality. SSH CENTRE is based in a range of activities related to Open Science, inclusivity and diversity – especially with regards Southern and Eastern Europe and different career stages –  including: development of novel SSH-STEM collaborations to facilitate the delivery of the EU Green Deal; SSH knowledge brokerage to support regions in transition; and the effective design of strategies for citizen engagement in EU R&I activities. Outputs include action-led agendas and building stakeholder synergies through regular Policy Insight events.This is captured in a high-profile virtual SSH CENTRE generating and sharing best practice for SSH policy advice, overcoming fragmentation to accelerate the EU’s journey to a sustainable future.The documents uploaded here are part of WP2 whereby novel, interdisciplinary teams were provided funding to undertake activities to develop a policy recommendation related to EU Green Deal policy. Each of these policy recommendations, and the activities that inform them, will be written-up as a chapter in an edited book collection. Three books will make up this edited collection - one on climate, one on energy and one on mobility. On the 22 November 2023, the International Energy Agency (IRENA) and the Institute for European Energy and Climate Policy (IEECP) organised a hybrid workshop on stakeholder-driven energy scenarios for a just transition. It brought together the scientific community, modellers in governmental institutions, and other energy and climate actors to discuss the importance of developing more partcipatory scenarios for a more inclusive and just transition, as well as the possibilities of involving the wider and interdisciplinary scientific community in national energy scenario planning. The background and agenda are provided in the workshop agenda document.
How p53 and PSF enhance pre-mRNA processing after being recruited to the start point of transcription
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Cancer is generally characterized by the widespread derangement of RNA processing, both splicing and cleavage/polyadenylation. Usually this is manifested as a shift in the balance of alternative processing choices. Seemingly minor changes at the RNA processing level can often lead to major alterations of cellular fate. Tumor suppressors and oncoproteins often govern alternative RNA processing choices, and in many instances they do so after being recruited to the start point of transcription. How do these proteins project their influence from a location at the startpoint of transcription to the sites of RNA processing far downstream? Addressing this problem begins with the understanding that transcription and the subsequent processing of the RNA produced are, in fact, tightly coordinated processes. One highly favored model proposes that RNA processing regulators are recruited to the start point of transcription, where they then bind to the RNA polymerase which transports them down the gene as the RNA is being made. These regulators are thereby poised to act as soon as the processing signals in the RNA are extruded from the polymerase. However, it has proven extremely difficult to obtain direct molecular evidence in favor of (or against) this model because of the difficulty of reproducing the coupling between transcription and processing in a biochemical setting (in vitro). We have recently developed such a system and have used it to show that the tumor suppressor p53, when recruited to the start of transcription, exerts a powerful effect on processing downstream. We show that this effect does not occur via the “recruitment” model described above, or by another highly favored “kinetic” model. Instead, the remarkable result is that p53 seemingly imprints a molecular memory on the RNA polymerase itself, either by means of a durable covalent modification that is not altered during any part of the transcription cycle, or through the extremely tenacious binding of an as yet unidentified protein. This imprint is shown to be directly responsible for the ability of the polymerase to enhance processing—by well over an order of magnitude. Here I propose experiments which make use of our in vitro system together with DNA templates immobilized on magnetic beads to prepare imprinted transcription elongation complexes for analysis. Mass spectrometry will be used in an attempt to identify the imprint, and functional studies will be carried out to characterize the mode and target of processing fac
Climatic and tectonic controls on ferroan dolomite formation: insights on Early Miocene Mediterranean anoxia (il-Blata, Malta)
Creators: name: Zammit, Ray
name: Petrash, D. A.
name: Bialik, O. M.
Publisher: name: Geological Society of London
Year: 2025
Subjects: classificationCode: 3705
subject: Geology
subject: FOS: Earth and related environmental sciences

description: Supplementary Information.
Tetramorium humbloti Forel
Creators: name: Bolton, B.
Publisher: name: Zenodo
Year: 1979
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium humbloti

description: Tetramorium humbloti Forel
Tetramorium {Xiphomyrmex) humbloti Forel, 1891 a: 154, pl. 4, fig. 12. Syntype workers, Comoro Is.: Grand Comoro I., Ngasiya (L. Humblot) (MHN, Geneva) [examined].
Worker. TL 3.4 - 4.1, HL 0.80 - 0.94, HW 0.74 - 0.88, CI 92 - 95, SL 0.56 - 0.72, SI 74 - 84, PW 0.54 - 0.66, AL 0.88 - 1.08 (30 measured).
Mandibles finely longitudinally striate. Antennal scrobes represented by an impressed area bounded above by the frontal carinae but without a differentiated ventral margin. Alitrunk in profile with the propodeum sloping downwards strongly from the metanotal groove to the base of the stout, acute spines. Metapleural lobes acutely triangular and generally slightly upcurved. Both petiole and postpetiole strongly anteroposteriorly compressed, in profile narrow and much higher than the dorsum is long, in dorsal view markedly transverse, much broader than long, in general form similar to that of bessoni, Fig. 9. Head strongly longitudinally rugulose, often with cross-meshes and always with the spaces between the rugulae reticulate-punctate. Dorsal alitrunk unsculptured or at most with some weak punctulation on the pro- or mesonotum. Pedicel segments and gaster unsculptured. Head with sparse, fine, erect hairs. Alitrunk and pedicel usually without hairs but rarely with 2 - 6 hairs present on the former. First gastral tergite always without hairs, but remaining tergites with them. Colour varying from light to dark brown, the gaster sometimes darker in shade than the alitrunk.
T. humbloti is an African species which has extended its range to include the Comoro Islands, but has not yet been discovered on the mainland of Madagascar. In Madagascar is a sibling of humbloti, T. bessoni, which has the head consistently less strongly sculptured and also tends to be more densely hairy than humbloti. Details for their separation are noted in the key.
As noted above, humbloti really belongs to the Ethiopian region fauna, and the description is based mainly upon such material. Discussion of the synonymy and distribution of humbloti is not given here as it will be dealt with in the part of this study dealing with the Ethiopian region.
description: Published as part of Bolton, B., 1979, The ant tribe Tetramoriini (Hymenoptera: Formicidae). The genus Tetramorium Mayr in the Malagasy region and in the New World., pp. 129-181 in Bulletin of the British Museum (Natural History) Entomology 38 on page 142
Additional file 1:Table S1. of High-throughput gadobutrol-enhanced CMR: a time and dose optimization study
Creators: name: D’Angelo, Tommaso
name: Chrysanthos Grigoratos
name: Mazziotti, Silvio
name: Bratis, Konstantinos
name: Faraz Pathan
name: Blandino, Alfredo
name: Elen, Elen
name: Puntmann, Valentina
name: Nagel, Eike
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biophysics
subject: Space Science
subject: Pharmacology
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Computational Biology

description: Late enhancement qualitative results at the different time delays for different doses of gadobutrol. Table S2. Late enhancement quantitative results (percentage of LGE myocardial mass) obtained at 10 min with 0.1 mmol/kg protocol and at 15 min with 0.2 mmol/kg protocol. (DOCX 58 kb)
Influence of pre-existing strike-slip faults on fault development during a subsequent phase of extension
Creators: name: Putra Ginting, Christian Satrianta
Publisher: name: No Publisher Supplied
Year: 2013

description: The goal of this study is to investigate how high-angle strike-slip faults affect deformation patterns during a subsequent phase of extension. To accomplish this goal, I use scaled experimental (analog) models with wet clay and two phases of deformation, an initial strike-slip phase and subsequent extensional phase. In Series 1 models, the extension direction varies during the second phase. In Series 2 models, the degree of the strike-slip-fault development varies during the first phase. The first-phase, right-lateral strike-slip deformation consists of subvertical Riedel shears, right-lateral R-shears and left-lateral R’-shears that strike ~15° and ~85°, respectively, relative to the trend of the deformation zone. In Series 1 models, the maximum extension direction relative to the strike of the pre-existing R- and R’-shears controls the likelihood of reactivation, the sense of slip on the reactivated faults, and the orientation of new normal faults. Pre-existing faults that are closer to being subperpendicular to the extension direction are more likely to be reactivated as high-angle normal faults. Additionally, some of the pre-existing R-shears are reactivated as tension gashes. Pre-existing faults that are closer to being subparallel to the extension direction are more likely to be reactivated as oblique-slip/strike-slip faults. Series 2 models show that new faults increasingly become more parallel to the orientation of R-shears as the pre-existing R-shears become better developed. In both Series 1 and 2 models, new faults commonly interact with pre-existing faults by cutting across, initiating at, and/or intersecting them. A pre-existing high-angle fault population can inhibit the development of new faults. A layered model shows that more faults cut the bottom of the clay than cut the top of the clay, suggesting that many faults nucleate at the base of the clay and propagate upward to the top of the clay. The reactivation of the pre-existing high-angle faults during a subsequent episode of extension and the interactions between pre-existing high-angle faults and new faults are comparable to those observed in the Suez rift system.
Abrodictyum C. Presl (Presl 1843
Creators: name: Ahamada H. Saïd
name: Sabine Hennequin
name: Germinal Rouhan
name: Jean-Yves Dubuisson
Publisher: name: Zenodo
Year: 2017
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Polypodiopsida
Hymenophyllales
Hymenophyllaceae
Abrodictyum

description: Genus Abrodictyum C. Presl (Presl 1843)
This pantropical genus comprises almost 25 species which are mostly terrestrial (and a few epiphytic) ferns displaying erect, large, highly-divided fronds on a short-creeping (or long-creeping in some Asiatic species) to erect stout rhizomes bearing numerous robust roots (Fig. 4). All Comorian specimens represent only one species although they are identified as either A. rigidum (Sw.) Ebihara & Dubuisson or A. cupressoides (Desv.) Ebihara & Dubuisson. These two species are indeed commonly confused in collections. Kuhn (1868) also cited Trichomanes obscurum Blume (= Abrodictyum obscurum (Blume) Ebihara & K.Iwats.) for Mayotte, but this species is in fact restricted to Asia and is clearly distinct even if also often confused with A. rigidum. Recent morphological and molecular studies focused on A. cupressoides and paleotropical A. rigidum evidenced that A. cupressoides is endemic to Seychelles and is in fact nested within the distinct genus Trichomanes (Bauret et al. 2015). Trichomanes cupressoides Desv. is thus absent from Comoros. Furthermore, specimens of the Malagasy region (including Comoros) formerly identified as A. rigidum actually represent a distinct species from the true neotropical A. rigidum (Bauret et al. 2015), and this new species has recently been described and named Abrodictyum pseudorigidum Bauret & Dubuisson (Dubuisson et al. 2016).
description: Published as part of Ahamada H. Saïd, Sabine Hennequin, Germinal Rouhan & Jean-Yves Dubuisson, 2017, Disentangling the diversity and taxonomy of Hymenophyllaceae (Hymenophyllales, Polypodiidae) in the Comoros, pp. 1-53 in European Journal of Taxonomy 313 on page 9, DOI: 10.5852/ejt.2017.313, http://zenodo.org/record/896401
Performing ethnic identities in global economies
Creators: name: Rajasingham, Nimanthi
Publisher: name: No Publisher Supplied
Year: 2013

description: This dissertation explores the aesthetics of contemporary globalization and ethnic war. It analyzes how literary texts and performances express the relationship between neoliberal doctrines, the idea that economies work best when least regulated, and ethnic wars in the global south.  This work uses cultural examples from Sri Lanka as it was the first country in the South Asian region to open its economies to neoliberalism in the 19&0s, and subsequently experienced thirty years of brutal ethnic war between the Sinhala majoritarian state and the minority Tamil Tigers. The cultural and aesthetic examples I analyze also demonstrate how both global forces and ethnic conflicts rework colonial and precolonial forms of power. Using an expanded definition of literature that takes us from the page to the stage and beyond, my chapters consider state-sponsored village festivals, workers’ plays and everyday practices, high-culture performances, and diasporic prize-winning fiction. Each chapter illustrates how transnational networks linked to neoliberal doctrines–such as development aid into rural villages, multinational capital into export processing zones, and human rights regimes into conflict zones–are interpreted and performed, and how local conditions may change the character of neoliberalism. When I investigate creative expressions that refuse the logic of war and nationalism, I point to cross-cultural exchanges that provided artists with models for social protest.  Sri Lankan examples add to literatures on globalization by scholars like Frederic Jameson, Gayatri Spivak, and David Harvey by expanding their theories of late capitalism to study its relationship to ethnic wars.  Similarly, my work expands arguments made by scholars like Mahmood Mamdani, and Valentine Daniel by expanding their arguments about ethnic and communal violence by linking them to late capitalism.
Evaluation of two NOS1AP regulatory variants and NOS1 as a candidate gene contributing to schizophrenia risk
Creators: name: Ramirez, Carmen
Publisher: name: No Publisher Supplied
Year: 2013

description: Schizophrenia is a major neuropsychiatric disorder that affects approximately one percent of the general population. Although the etiology of schizophrenia is unknown, family, twin and adoption studies have demonstrated that schizophrenia is a predominantly genetic disorder with a very high heritability.  We previously reported highly significant evidence of linkage to chromosome 1q21-23, identified NOS1AP as the candidate gene from this region contributing to risk for schizophrenia in our sample, and identified three SNPs with strong evidence of association to schizophrenia. These SNPs were tested for regulatory functions using a Dual Luciferase Reporter Assay. rs12&42393 demonstrated regulatory activity and produced significant allelic expression differences in two different human neural cell lines. Further statistical analysis of eight SNPs in strong LD with rs12&42393 identified a haplotype block of four SNPs in complete LD with each other (rs455&949-rs11584803-rs4145621-rs12084492) with strong evidence of association to schizophrenia.  Additional statistical analysis revealed that a haplotype of rs12&42393 and this block produced stronger evidence for association than rs12&42393 alone. rs4145621 already has been tested for regulatory activity and produced no evidence of being a functional variant. The focus of this thesis was to evaluate the regulatory activity of two of these SNPs within this haplotype, rs12084492 and rs455&949. We performed Dual-Luciferase Reporter Assays to test for regulatory function of each SNP individually and in combination with rs12&42393 using two different cell lines, PFSK-1 and SK-N-MC, and using different cell confluence levels. Our results suggest that both SNPs are not functional variants. Evaluation of rs11584803 is necessary to completely test our initial hypothesis.
Novel anti-oncogene function of p53
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Background: The tumor suppressor gene TP53 and the proto-oncogene MYC are frequently altered genes in human cancer and their deregulation is associated with most types of malignancies in humans and is tumorigenic in animal models. The MYC oncoprotein and the p53 tumor suppressor protein are transcription regulators that can influence each other’s genetic programs in a cell context-dependent manner. In normal cells, p53 protein levels and downstream pathways leading to apoptotic cell death are induced by deregulated/overexpressed MYC (e.g.,via the ARF-MDM2 pathway) as a safeguard against uncontrolled MYC-driven cell proliferation and cancer development. On the other hand, MYC has been reported to inhibit p53-dependent apoptosis in ARF-deficient cancer cells. The molecular mechanisms for the antagonistic functions of p53 and MYC on each oher’s pathways are generally thought to be indirect but remain poorly understood. Here, based on preliminary studies, we propose that p53 and MYC proteins may influence each other’s transcription regulatory activities via direct physical interactions. Aims: The objectives of the proposed research are (1) to verify and characterize the p53-MYC interaction in cells and in vitro and (2) to analyze the role of the p53-MYC interaction in transcription of p53 and MYC target genes. Methods: Transfection, co-immunoprecipitation and Western blot analyses will be used to test MYC-p53 interaction in normal and transformed human cells; sub-cellular co-localization studies will be performed by double immunofluorescence and imaging on a high-resolution UV confocal microspcope (Leica SP2). In vitro protein-protein interaction assays will be performed by “GST pull-down” with cell extracts and purified recombinant proteins. Binding of MYC and p53 to target genes in cells will be tested by chromatin immunoprecipitation; in vitro DNA-binding will be assayed by “gel-shift” with recombinant purified proteins. Analyses of gene transcription will be performed by quantitative/real-time reverse transcription PCR (qRT-PCR) and Luciferase reporter gene assays. Depletion of p53 and/or MYC will be performed by RNA interference (RNAi). Relevance: These studies will uncover a novel mechanism by which the p53 tumor suppressor exerts its anti-oncogenic functions and will demonstrate for the first time a direct crosstalk between p53 an MYC, the products of the two most frequently altered genes in cancer.
A nanoengineering approach for regulation of actin machinery in focal adhesion process of cancer cells
Creators: name: University Of California Office Of The President
Publisher: name: University of California Office of the President
publisherIdentifier: https://ror.org/00dmfq477
publisherIdentifierScheme: ROR
Year: 2024

description: Formation of focal adhesion, podosomes and invadopodia are of fundamental importance in cellular adhesion and other functions including cancer cell invasion across tissue barriers. Invasion is frequently correlated with characteristic actin-membrane features, such as invadopodia, which are membrane protrusions that are associated with localized polymerization of sub-membrane actin filaments. The long-term goal is to develop nanobiotechnology that allows understanding of the integrin related and actin-participated signal transduction processes in time and in space, and with that knowledge to devise strategies to alter the behavior of cells in general, and specifically the invasion behavor of cancer cells. The idea is based on two main observations (a) that the clustering of integrin initiated by ligand binding results in recruitment of focal adhesion proteins such as tensin and tyrosine kinases to the integrin clusters, and then mediates further downstream cell singlings leading to cell adhesion, migration, and gene expression; (b) that the ring-like structures (the so-called rosette) are present for podosomes in osteoclasts and invadopodia in Src-transformed cells. We hypothesize that by engineering the ECM containing designed geometry at nanometer level, such as clusters and rings, we should be able to guide and facilitate the clustering of integrin thus the focal adhesion, and the formation of rosette thus the podosomes and invadopodia, respectively. The corresponding characteristic membrane features as dictated by actin dynamics underneath will also be controlled by the engineering parameters. Two specific aims: Aim 1. Design, production and characterization of nanostructures consisting integrinbinding ligands such as fibronectin. Using atomic force microscopy (AFM) based nanolithography method known as nanografting, we plan to focus on reaching nanometer resolution and precision and to ensure a practical throughput. Aim 2. To investigate how the geometry of the Fn nanostructures impact the integrin clustering and rosette formation, and the corresponding actin structures. Using combined AFM and laser scanning confocal imaging as well as single cell mechanics, we plan to monitor the signaling process using the structural characterization and Young’s moduli.
Tetramorium marginatum Forel
Creators: name: Bolton, B.
Publisher: name: Zenodo
Year: 1979
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Insecta
Hymenoptera
Formicidae
Tetramorium
Tetramorium marginatum

description: Tetramorium marginatum Forel
(Figs 10, 11)
Tetramorium {Xiphomyrmex) marginatum Forel, 1895 b: 485. Syntype workers, Madagascar: central Madagascar {Sikora) (MHN, Geneva) [examined].
Worker. TL 3.8 - 3.9, HL 0.84 - 0.86, HW 0.78, CI 90 - 93, SL 0.68 - 0.70, SI 87 - 90, PW 0.60, AL 1.00 - 1.02 (2 measured).
Mandible with a few faint and feeble striae but with extensive smooth areas. Clypeus with a sharp, fine median carina. Frontal carinae short, ending just posterior to the level of the eyes. Antennal scrobes very weak, merely short, shallow impressions below the frontal carinae and not as long as the antennal scapes. Pronotal corners rounded in dorsal view, the sides of the pronotum bluntly marginate. Dorsum of mesonotum and propodeum separated from the sides by an acute, very distinct margination which runs to the bases of the long, acute propodeal spines. Dorsal alitrunk between the margination transversely flat, longitudinally feebly convex. Metapleural lobes short and rounded. Petiole in profile anteroposteriorly compressed, the node tapering from base to apex as shown in Fig. 11. Dorsum of head with sparse, scattered, fine longitudinal rugulae which peter out posteriorly. Dorsal alitrunk unsculptured but with superficial patterning, the pedicel and gaster unsculptured. All dorsal surfaces of head and body with erect or suberect fine hairs. Head and alitrunk black or blackish brown, the pedicel and gaster dark brown.
Rendered highly conspicuous among the Malagasy tetramoriines by its lack of sculpture, sharply margined mesonotum and propodeum and compressed petiole, marginatum is unlikely to be confused with any other member of the genus from Madagascar or Africa.
Material examined
Madagascar: Rte d'Anosibe (W. L. & D. E. Brown); Beforona (A. Peyrieras).
description: Published as part of Bolton, B., 1979, The ant tribe Tetramoriini (Hymenoptera: Formicidae). The genus Tetramorium Mayr in the Malagasy region and in the New World., pp. 129-181 in Bulletin of the British Museum (Natural History) Entomology 38 on pages 142-143
Astyanax bransfordii
Creators: name: Angulo, Arturo
name: Betts, Joel T.
name: González-Alemán, Néstor J.
name: Castañeda, Edgar
name: Berghe, Eric Van Den
name: Elías, Diego J.
name: Mcmahan, Caleb D.
name: Matamoros, Wilfredo A.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Chordata
Characiformes
Characidae
Astyanax
Astyanax bransfordii

description: Astyanax bransfordii (Gill 1877) (Fig. 7A). Longjaw Tetra; Sardina, Sardina Picuda, Picuda, Sábalo, Sabalete, Sardina Hocicuda, Sardina Dientona
Vouchers: UCR 0024-001 (4), 0061-001 (1), 0063-005 (3), 0535-001 (6), 0542-004 (4), 0552-004 (2), 1051-017 (4), 1065-002 (4), 1066-006 (1) and 3122-003 (2); FMNH 5919 (18), 5920 (2), 5921 (1), 5922 (1), 33077 (1), 33078 (1), 33079 (1), 33080 (1), 33081 (1), 33082 (1), 33083 (1) and 105091 (1); LSUMZ 15475 (8); other collections: CAS 61538 (1), IBUNAM 13684 (1), TCWC 249201 (3), UF 93555 (1) and UMMZ 180608 (1). Distribution: Central America; from southwestern Nicaragua to northern Costa Rica, Atlantic drainages; (Nicaragua) Es, To, Sa, SJ, RF and LN (Atlantic); 4–87 masl; Pri, Pot. Occurrence and conservation status: Nat; NT B1ab(iii) (2020), population trend stable. Literature: Meek (1907: 110, as Bramocharax bransfordii —synonym, also as Bramocharax elongatus (Meek, 1097) —synonym; brief description, including an identification key, and information on distribution and ecology), Astorqui (1975: 74, as B. bransfordii —synonym; brief description, including illustrations and an identification key, and information on distribution and ecology), Villa (1982: 102, as B. bransfordii —synonym; detailed description, including illustrations and an identification key, and information on distribution and ecology), Bussing (1998: 88, as B. bransfordii —synonym; brief description, including illustrations and an identification key, and information on distribution, with a map, and ecology), González-Alemán (2006: 39, as B. bransfordii — synonym; brief description, including an illustration, and information on distribution and ecology), Schmitter-Soto (2017: 41; redescription, including illustrations and an identification key, and information on distribution, with a map, and ecology), Angulo et al. (2018: 1867; identification key and information on distribution) and Angulo (2021: 25; listed, including information on distribution).
description: Published as part of Angulo, Arturo, Betts, Joel T., González-Alemán, Néstor J., Castañeda, Edgar, Berghe, Eric Van Den, Elías, Diego J., Mcmahan, Caleb D. & Matamoros, Wilfredo A., 2023, Continental fishes of Nicaragua: diversity, distribution and conservation status; with an annotated and illustrated checklist of species and an identification guide to families, pp. 1-89 in Zootaxa 5376 (1) on page 22, DOI: 10.11646/zootaxa.5376.1.1, http://zenodo.org/record/10208788
Additional file 2: of Lactoferrin and lysozyme to reduce environmental enteric dysfunction and stunting in Malawian children: study protocol for a randomized controlled trial
Creators: name: Cheng, William
name: Wold, Karl
name: Benzoni, Nicole
name: Thakwalakwa, Chrissie
name: Maleta, Kenneth
name: Manary, Mark
name: Indi Trehan
Publisher: name: Figshare
Year: 2017
Subjects: subject: Space Science
subject: Medicine
subject: Cell Biology
subject: Ecology
subject: FOS: Biological sciences
subject: Sociology
subject: FOS: Sociology
subject: 69999 Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Infectious Diseases
subject: FOS: Health sciences

description: Assessment of the change in environmental enteropathy after supplementation with bovine lactoferrin and recombinant human lysozyme. (PDF 1177 kb)
Additional file 1: Table S1. of Quantifying the intensity of permethrin insecticide resistance in Anopheles mosquitoesÂ in western Kenya
Creators: name: Omondi, Seline
name: Mukabana, Wolfgang
name: Ochomo, Eric
name: Muchoki, Margaret
name: Kemei, Brigid
name: Mbogo, Charles
name: Nabie Bayoh
Publisher: name: Figshare
Year: 2017
Subjects: subject: Biochemistry
subject: Medicine
subject: Biotechnology
subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: 19999 Mathematical Sciences not elsewhere classified
subject: FOS: Mathematics
subject: Cancer
subject: 60506 Virology
subject: Computational Biology

description: Detailed results of the 2Â h CDC bottle bioassays performed for the different permethrin concentration in the four sub-counties in western Kenya. (DOCX 16 kb)
Triple intersection formulas for isotropic Grassmannians
Creators: name: Ravikumar, Vijay
Publisher: name: No Publisher Supplied
Year: 2013

description: A K-theoretic Pieri formula provides a convenient way to calculate the product of  arbitrary Schubert classes with certain special classes in the Grothendieck ring of a  homogeneous space. In this paper we calculate the triple intersection numbers of Pieri  type, for Grassmannians of types B, C, and D. These can be used to quickly compute  Pieri coefficients, and we hope they will lead to Pieri formulas in these cases.    We also summarize part of our earlier work with Anders Buch [BR12], in which triple  intersection numbers lie at the heart of a new geometric proof of Lenart’s K-theoretic  Pieri formula for type A Grassmannians [Len00].
The impact of school neighborhood disadvantage on bullying
Creators: name: Reyes-Portillo, Jazmin
Publisher: name: No Publisher Supplied
Year: 2013

description: This study sought to examine bullying in schools from an ecological systems perspective by assessing the role that important aspects of the school and neighborhood microsystems play in shaping student behavior and experiences. Specifically, this study examined whether school neighborhood socioeconomic status (SNSES) and school climate were associated with student reports of bullying, victimization, and others being bullied at school. The interaction between SNSES and school climate was also assessed. The sample included 9,603 students from 26 schools (49.&% were female and 50.1% self-identified as White, 15.&% as Latino, 12.3% as Mixed race/ethnicity, &.1% as Black, 6.5% as Asian, 2.&% as Middle Eastern and 5.4% as Other). Student grade levels ranged from 3 to 12. Bullying and school climate were assessed via student report. SNSES was assessed via 2000 U.S. Census data. Multilevel linear modeling was used to examine the study hypotheses. Results revealed that negative school climate and negative SNSES were associated with increased student reports of bullying, victimization, and others being bullied. Students in high SNSES schools reported less victimization at positive levels of school climate. There was little difference in student reported victimization across different levels of school climate among students in low SNSES schools. Implications for future research are discussed.
Pay status, work design, job satisfaction, and career development
Creators: name: Rogers, Sean Edmund
Publisher: name: No Publisher Supplied
Year: 2013

description: Volunteer labor – work performed for no remuneration – represents a sizable amount of labor power generated for nonprofit, public, and private organizations in the United States. Despite the tens of millions of men and women who donate their work to employers year in and year out, and despite the billions of dollars these unpaid workers save their employers in wage expenses annually, volunteers have received scant coverage in management and organizational scholarship. As a result, many of the fundamental aspects of work that have been studied concerning paid workers remain empirically unproven for volunteers.    This study represents an attempt to bring the academic study of volunteers into the mainstream of industrial relations, human resource management, and organizational behavior scholarship. Using literature and theory from several disciplines, and utilizing the case of paid and unpaid college student interns, the pay status of work is analyzed in terms of its relationship to job design, job satisfaction, and career development. For a range of reasons predicated upon theoretical and empirical positions from the management, volunteerism, and vocational development literatures, it was predicted that non-wage jobs would possess lower levels of work structure in terms of a job’s task, knowledge, social, and contextual-related characteristics, and that unpaid workers would be less satisfied with, and report fewer career development benefits from, their work than would paid work and workers.    A series of statistical analyses performed on data collected from 168 college interns partly supported the hypotheses put forth in this study. Volunteer interns indeed reported experiencing lower levels of knowledge and social characteristics than did their paid counterparts. However, no differences were found to exist between paid and unpaid workers on task and contextual dimensions of work. Additionally, paid and unpaid interns reported similar levels of satisfaction, as well as career development benefits, from their work experience.    This study shed new light on a workforce that has existed in America since its earliest years, but that has been largely overlooked by workplace scholars. Its findings, and the discussion and debate it hopefully prompts, stand to benefit employers, communities and societies, and most importantly, the volunteer workforce itself.
Magic bean
Creators: name: Roth, Matthew D.
Publisher: name: No Publisher Supplied
Year: 2013

description: In 1900, the soybean was a nonentity in American farming. By 2000, 8& million metric tons were grown each year and soy was the country’s most valuable agricultural export. A less concrete but perhaps more telling difference was the soybean’s increased presence in American culture: in 1900, a small number of Asian immigrants, adventuresome farmers, and agricultural researchers thought about soybeans on a regular basis.  By 2000, that number had expanded to include chemical, nutritional and medical researchers; commodities traders; lobbyists; vegetarians and millions more buying tofu or soy health-foods; sufferers of soybean allergies; and countless others.  Magic Bean charts the diverse paths of the soybean into American farming, diet and culture over the course of the twentieth century.  These pathways were enmeshed in systems of knowledge and cultural transfer that themselves underwent enormous transformations in that time: immigrant networks, missionary enterprises, agricultural science, laboratory chemistry, commodities markets, spiritual pilgrimages, and marketing techniques.  In tracking the career of the soybean in America, Magic Bean takes a broadly ecological approach that highlights the interconnections between the environment, science and culture, while never losing sight of the aspirations of individuals whose quests drove the process forward.