Synthesis, spectroscopic characterization, antimicrobial activity, molecular docking and DFT studies of proton transfer (H-bonded) complex of 8-aminoquinoline (donor) with chloranilic acid (acceptor)
Creators: name: Khan, Ishaat M.
name: Islam, Maidul
name: Shakya, Sonam
name: Alam, Nisat
name: Imtiaz, Shah
name: Islam, Md. Rabiul
Publisher: name: Taylor & Francis
Year: 2021
Subjects: subject: Biophysics
subject: Biochemistry
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences

description: The proton transfer complex has been synthesized by mixing 1:1 ratio of 8-aminoquinoline (donor) and chloranilic acid (acceptor) in methanol. FTIR, <sup>13</sup>C NMR, <sup>1</sup>H NMR, Powder XRD and UV-visible studies confirmed the formation of the newly synthesized compound. These methods ascertain that cations and anions combine to form weak hydrogen bonds as N<sup>+</sup>–H----O<sup>–</sup>. The physical properties such as energy of interaction (E<sub>CT</sub>), resonating energy (R<sub>N</sub>), Ionization potential (I<sub>D</sub>), and oscillator strength (f), transition dipole strength (D) and free energy (Δ G) were estimated through UV-visible spectroscopy. The thermal stability of this complex and extensive erosion was analyzed by TGA/DTA study. Benesi-Hildebrand equation was used to determine 1:1 stoichiometry of this complex and to calculate the molar extinction coefficient (<i>ε<sub>CT</sub></i>), the formation constant (K<sub>CT</sub>) and other physical parameters. The nature of transfer of charge relations plays a vital role in chemistry and in biological systems. The synthesized proton transfer complex has been screened for antibacterial activities against different bacteria and antifungal activities against different fungi. The proton transfer complex also displays outstanding interaction with the human protein (globulin) protein. The DFT calculations by B3LYP/6-311G** basis set gave theoretical establishment and HOMO (−5.468 eV) to LUMO (−3.328 eV) electronic energy gap (ΔE) as 2.140 eV. Theoretical analysis proves the biological characteristics as well. Molecular docking displays that CT complex is fully bound to the protein and determines the free binding energy value of −290.18 kcal/mol (FEB). A new organic charge transfer complex has been prepared, characterized and explored for antibacterial, antifungal and protein binding properties. The experimental results are supported by theoretical analysis. Communicated by Ramaswamy H. Sarma HighlightsCharge transfer complex was synthesized and characterized by various techniques.Spectrophotometric studies were made in different polar solvents. K<sub>CT,</sub> <i>ε</i><sub>CT</sub> and E<sub>CT</sub> of were determined using Benesi-Hildebrand equation.Structure and hydrogen-bonding network were also investigated by FT-IR and NMR (<sup>1</sup>H &amp; <sup>13</sup>C).Thermal analysis (TGA–DTA) was also used to confirm the thermal fragmentation and the stability of the CT-complex.Synthesized CT-complex was screened for its antimicrobial activity and protein (globulin) binding. Charge transfer complex was synthesized and characterized by various techniques. Spectrophotometric studies were made in different polar solvents. K<sub>CT,</sub> <i>ε</i><sub>CT</sub> and E<sub>CT</sub> of were determined using Benesi-Hildebrand equation. Structure and hydrogen-bonding network were also investigated by FT-IR and NMR (<sup>1</sup>H &amp; <sup>13</sup>C). Thermal analysis (TGA–DTA) was also used to confirm the thermal fragmentation and the stability of the CT-complex. Synthesized CT-complex was screened for its antimicrobial activity and protein (globulin) binding.