cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Chemical composition and antioxidant activity of a polar extract of Thymelaea microphylla Coss. et Dur.
Creators: name: Khawla Kerbab
name: Tarak Mekhelfi
name: Lahcene Zaiter
name: Benayache, Samir
name: Benayache, Fadila
name: Picerno, Patrizia
name: Mencherini, Teresa
name: Sansone, Francesca
name: Aquino, Rita P.
name: Rastrelli, Luca
Publisher: name: Taylor & Francis
Year: 2015
Subjects: Science Policy
Developmental Biology
Biological Sciences
Chemistry
Earth and Environmental Sciences
Biotechnology
Pharmacology
Biochemistry

description: Thymelaea microphylla Coss. et Dur. (Thymelaeaceae) is a rare medicinal plant endemic to Algeria. In order to continue our studies on this species, herein we report the isolation and characterisation of 20 compounds from a hydroalcoholic extract (EtOH–H2O 7:3) of the aerial parts. They include monoterpene glucosides (1–3), phenolic acid derivatives (4, 8 and 9), phenylpropanoid glucosides (5 and 6), flavonoids (7, 10 and 11), a benzyl alcohol glucoside (12), ionol glucosides (13–16), lignans (17–19) and a bis-coumarin (20). All the structures were elucidated by spectroscopic methods including 1D and 2D NMR experiments, as well as ESI-MS analysis. Moreover, the extract of T. microphylla showed a significant and concentration-dependent free radical-scavenging activity in vitro, correlated to the presence of phenolic and chlorogenic acid derivatives (8, 9 and 4).
Chemical composition and anti-inflammatory activities of the essential oils from Acacia mearnsii de Wild
Creators: name: Opeyemi N. Avoseh
name: Ope-Oluwa O. Oyedeji
name: Kayode Aremu
name: Nkeh-Chungag, Benedicta N.
name: Sandile P. Songca
name: Oluwafemi, Samuel O.
name: Adebola O. Oyedeji
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Mathematics
subject: FOS: Mathematics
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Genetics
subject: Microbiology
subject: Biochemistry

description: The volatile oils of the leaves and the stem bark of Acacia mearnsii de Wild obtained by hydro-distillation were analysed by gas chromatography–mass spectrometry. A total of 20, 38, 29 and 38 components accounted for 93.8%, 92.1%, 78.5% and 90.9% of the total oils of the fresh, dry leaves and fresh, dry stem bark, respectively. The major components of the oil were octadecyl alcohol (25.5%) and phytol (10.5%); cis-verbenol (29.5%); phytol (10.1%) and phytol (23.4%) for the fresh leaves, dried leaves, fresh stem, dry stem bark, respectively. Oral administration of essential oils at a dose of 2% showed significant (p A. mearnsii hereby confirmed its traditional use in treating various inflammatory diseases.
In vitro anti-cataract evaluation of standardised Abies pindrow leaf extract using isolated goat lenses
Creators: name: Suchita Dubey
name: Saha, Sudipta
name: Shubhini A Saraf
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Science Policy
subject: Cancer
subject: Biological Sciences
subject: Ecology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Molecular Biology
subject: Cell Biology
subject: Biochemistry
subject: Biophysics

description: Oxidative stress is known to spark off the pathogenesis of cataract. Antioxidant potential of Abies pindrow Royle leaf extract (APE) is well established in the literature. In this context, standard aqueous leaf extract of this plant was evaluated for its role in hydrogen peroxide-induced cataract in isolated goat lenses using varying concentrations (5, 10, 15 and 20 mg/mL). Total phenol and flavonoidal content was evaluated and found to be high in concentration. Biochemical parameters, namely superoxide dismutase (SOD), glutathione (GSH), total protein content (TPC) and malondialdehyde (MDA), were evaluated. SOD, GSH and TPC formation was found to increase proportionally with increasing concentration. However, MDA level decreased significantly as the concentration of the extract increased. The results suggest that the extract under investigation can delay the onset and/or prevent the progression of cataract. Its anti-cataract potential may be attributed to the presence of high phenolics and flavonoids in APE. Photographic evaluation, further, confirmed the observation.
Isolation of a new lycodine alkaloid from Lycopodium japonicum
Creators: name: Jichun Wu
name: Huanqin Wang
name: Yanfang Ma
name: Jinhe Jiang
name: Zhan, Rui
name: Yegao Chen
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biochemistry

description: A new lycodine alkaloid, N-methylhydroxypropyllycodine (1), was isolated from the club moss Lycopodium japonicum Thunb, together with five known compounds, N-methyllycodine (2), huperzinine (3), β-obscurine (4), α-obscurine (5) and des-N-methyl-α-obscurine (6). Their structures were elucidated by spectroscopic analyses, including 2D NMR techniques.
Two high-risk susceptibility loci at 6p25.3 and 14q32.13 for Waldenström macroglobulinemia
Creators: name: Melbye, M.
name: Chatterjee, N.
name: Maria, A.
name: Goldin, L.R.
name: Vijai, J.
name: de Sanjose, S.
name: Li, S.A.
name: Benavente, Y.
name: Slager, S.L.
name: Kraft, P.
name: Purdue, M.P.
name: Lawrence, C.
name: Jackson, R.D.
name: Vermeulen, R.C.H.
name: North, K.E.
name: Kleinstern, G.
name: Hutchinson, A.
name: Smith, A.
name: Besson, C.M.
name: Smedby, K.E.
name: Mayr, C.
name: Fansler, M.M.
name: Conde, L.
name: Cerhan, J.R.
name: Maynadie, M.
name: Giovannucci, E.
name: Burdette, L.
name: Boffetta, P.
name: Bassig, B.A.
name: Hjalgrim, H.
name: McKay, J.
name: Hofmann, J.N.
name: Berndt, S.I.
name: Novak, A.J.
name: Ansell, S.M.
name: Cozen, W.
name: Adami, H.-O.
name: Nieters, A.
name: Yeager, M.
name: Travis, R.C.
name: Weiderpass, E.
name: Zhang, J.
name: Becker, N.
name: Rothman, N.
name: Morton, L.M.
name: Park, J.-H.
name: Brown, E.E.
name: Birmann, B.M.
name: Zhang, Y.
name: Link, B.K.
name: Montalvan, R.
name: Ojesina, A.I.
name: Foretova, L.
name: Caporaso, N.E.
name: Clavel, J.
name: Glimelius, B.
name: Offit, K.
name: Bracci, P.M.
name: Vajdic, C.M.
name: Staines, A.
name: Brennan, P.
name: Skibola, C.F.
name: Severson, R.K.
name: McMaster, M.L.
name: Feldman, A.L.
name: Tinker, L.F.
name: Teras, L.R.
name: Vineis, P.
name: Diver, W.R.
name: Wang, Z.
name: Canzian, F.
name: Chanock, S.J.
name: Pradhan, N.
name: Chung, C.C.
name: Zhu, B.
name: Riby, J.
name: Hicks, B.D.
name: Lan, Q.
name: Zheng, T.
name: Yan, H.
name: Monnereau, A.
Publisher: name: Nature Publishing Group
Year: 2018

description: Waldenström macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL) is a rare, chronic B-cell lymphoma with high heritability. We conduct a two-stage genome-wide association study of WM/LPL in 530 unrelated cases and 4362 controls of European ancestry and identify two high-risk loci associated with WM/LPL at 6p25.3 (rs116446171, near EXOC2 and IRF4; OR = 21.14, 95% CI: 14.40–31.03, P = 1.36 × 10−54) and 14q32.13 (rs117410836, near TCL1; OR = 4.90, 95% CI: 3.45–6.96, P = 8.75 × 10−19). Both risk alleles are observed at a low frequency among controls (~2–3%) and occur in excess in affected cases within families. In silico data suggest that rs116446171 may have functional importance, and in functional studies, we demonstrate increased reporter transcription and proliferation in cells transduced with the 6p25.3 risk allele. Although further studies are needed to fully elucidate underlying biological mechanisms, together these loci explain 4% of the familial risk and provide insights into genetic susceptibility to this malignancy.
Chemotyping of diverse Eucalyptus species grown in Egypt and antioxidant and antibacterial activities of its respective essential oils
Creators: name: Salem, Mohamed Z.M.
name: Ashmawy, Nader A.
name: Hosam O. Elansary
name: El-Settawy, Ahmed A.
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Plant Biology
subject: FOS: Biological sciences
subject: Inorganic Chemistry
subject: FOS: Chemical sciences
subject: Developmental Biology
subject: Biological Sciences
subject: Sociology
subject: FOS: Sociology
subject: Ecology
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Molecular Biology
subject: Cell Biology
subject: Microbiology
subject: Biochemistry

description: The chemical composition of the essential oil from the leaves of Eucalyptus camaldulensis, Eucalyptus camaldulensis var. obtusa and Eucalyptus gomphocephala grown in northern Egypt was analysed by using GC-FID and GC–MS techniques. The antibacterial (agar disc diffusion and minimum inhibitory concentration methods) and antioxidant activities (2,2′-diphenypicrylhydrazyl) were examined. The main oils constituents were 1,8-cineole (21.75%), β-pinene (20.51%) and methyleugenol (6.10%) in E. camaldulensis; spathulenol (37.46%), p-cymene (17.20%) and crypton (8.88%) in E. gomphocephala; spathulenol (18.37%), p-cymene (19.38%) and crypton (16.91%) in E. camaldulensis var. obtusa. The essential oils from the leaves of Eucalyptus spp. exhibited considerable antibacterial activity against Gram-positive and Gram-negative bacteria. The values of total antioxidant activity were 70 ± 3.13%, 50 ± 3.34% and 84 ± 4.64% for E. camaldulensis, E. camaldulensis var. obtusa and E. gomphocephala, respectively. The highest antioxidant activity value of 84 ± 4.64% could be attributed to the high amount of spathulenol (37.46%).
Bisexual Women’s Female Friendships: Predictors and Outcomes of Sexual Identity Disclosure
Creators: name: Parekh, Nina
Publisher: name: Digital Repository at the University of Maryland
Year: 2020
Subjects: subject: Psychology
subject: FOS: Psychology
subject: BSOS
subject: Parekh
subject: bisexual
subject: friendships
subject: women
subject: sexual identity disclosure

description: This study examined identity-based predictors of bisexual women’s sexual identity disclosure and outcomes of disclosure related to individual and interpersonal well-being. The study assessed hypotheses that Asian bisexual women would be less likely to disclose their sexual minority status to Asian friends and more likely to White friends, as well as less likely to monosexual friends. The study also identified that the act of sexual identity disclosure for all participants, regardless of race/ethnicity would experience stronger interpersonal wellbeing among the friends to which they have disclosed their sexual minority status. A sample of bisexual women completed measures focused on their demographic information, personal self-esteem, self-authenticity, satisfaction with life, and perceived social support, as well as their interpersonal level of outness, validation, trust, intimacy, and overall friendship.
title: Development and understanding of iron-catalysed C–H functionalisation reactions
title: The development and understanding of iron-catalysed C–H functionalisation reactions
titleType: AlternativeTitle
Creators: name: Britton, Luke Aaron
Publisher: name: The University of Edinburgh
Year: 2024
Subjects: subject: iron-catalysed C–H functionalisation reactions
subject: C–H functionalisation
subject: Earth-abundant metal-catalysed methods
subject: iron-catalysed C–H borylation reaction of arenes
subject: Earth-abundant metalcatalysed C–H borylation reaction
subject: C–H borylation of 2-phenylpyridine derivatives
subject: Brønsted acid catalysis
subject: parallel non-metal-catalysed reaction conditions
subject: iron-catalysed hydrogen isotope exchange (HIE)

description: C–H functionalisation reactions allow for an efficient and sustainable manner of increasing molecular complexity. The application of Earth-abundant metal-catalysed methods is dependent on systems that are reliable, predictable, and easily accessible. However, current methods typically show limited reaction tolerances, often have little mechanistic understanding, and rely on highly sensitive reagents and pre-catalysts. An iron-catalysed C–H borylation reaction of arenes has been developed using only commercially available, bench-stable reagents (Scheme A-1). The reaction demonstrates the largest functional group tolerance of any Earth-abundant metalcatalysed C–H borylation reaction and provides insight into observed side reactivity. Mechanistic studies of an iron halide-catalysed system for the directed C–H borylation of 2-phenylpyridine derivatives identified iron to be an initiator in a reaction driven by hidden Brønsted acid catalysis. The development of parallel non-metal-catalysed reaction conditions and methods for main group catalyst activation has also been demonstrated. Mechanistic studies on an iron-catalysed hydrogen isotope exchange (HIE) reaction of heteroarenes and alkenes identified the modes of exchange and a novel method for accessing iron-hydrides in situ. Reaction selectivity and the isolation of catalytic intermediates, including products of C–H metallation, suggested deuterium incorporation was proceeding through a selection of reaction pathways.
Plusiocampa (Dydimocampa) euxina Conde 1996
Creators: name: Sendra, Alberto
name: Antić, Dragan
name: Barranco, Pablo
name: Borko, Špela
name: Christian, Erhard
name: Delić, Teo
name: Fadrique, Floren
name: Faille, Arnaud
name: Galli, Loris
name: Gasparo, Fulvio
name: Georgiev, Dilian
name: Giachino, Pier Mauro
name: Kovac, L'ubomír
name: Lukić, Marko
name: Marcia, Paolo
name: Miculinić, Kazimir
name: Nicolosi, Giuseppe
name: Palero, Ferran
name: Paragamian, Kaloust
name: Pérez, Toni
name: Polak, Slavko
name: Prieto, Carlos E.
name: Turbanov, Ilya
name: Vailati, Dante
name: Reboleira, Ana Sofia P. S.
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Entognatha
Diplura
Campodeidae
Plusiocampa
Plusiocampa euxina

description: Plusiocampa (Dydimocampa) euxina Condé, 1996
Plusiocampa euxina Condé, 1996: 102, figs 1–6.
Diagnosis (Condé 1996)
Troglomorphic species. Antennae with 44–45 antennomeres; eight to ten complex olfactory chemoreceptors in cupuliform organ; slightly protruding frontal process with a few anterior tubercular setae. Pronotum with 1+1 ma, 1+1 la, 2+2 lp macrosetae; mesonotum with 1+1 ma, 2+2 la, 2+2 lp macrosetae; metanotum with 1+1 ma, 1+2 la, 2+2 lp macrosetae; long, barbed notal macrosetae; sparse short, smooth notal clothing setae. Three ventral tibial macrosetae; unequal claws (1.25) with large lateral crests, posterior claw with a small backward overhang; short lateral processes. Urotergites I–III with 1+1 post macrosetae; urotergite IV with 1+1 la, 4+4 post macrosetae; urotergite V with 2+2 la, 4+4 post macrosetae; urotergites VI–VII with 2+2 la, 5+4 post macrosetae; urotergite VIII with 6+6 post macrosetae; abdominal segment IX with 9+9 post macrosetae; urosternite I with 8+7, urosternites II–VII with 6+6, urosternite VIII with 2+2 macrosetae. Male without glandular g 1 setae, enlarged subcylindrical appendages with a large area of glandular a 1 setae; adult female unknown.
Habitat and distribution
Subterranean species inhabiting the Movile Cave, Southern Dubrudja, Romania.
description: Published as part of Sendra, Alberto, Antić, Dragan, Barranco, Pablo, Borko, Špela, Christian, Erhard, Delić, Teo, Fadrique, Floren, Faille, Arnaud, Galli, Loris, Gasparo, Fulvio, Georgiev, Dilian, Giachino, Pier Mauro, Kovac, L'ubomír, Lukić, Marko, Marcia, Paolo, Miculinić, Kazimir, Nicolosi, Giuseppe, Palero, Ferran, Paragamian, Kaloust, Pérez, Toni, Polak, Slavko, Prieto, Carlos E., Turbanov, Ilya, Vailati, Dante & Reboleira, Ana Sofia P. S., 2020, Flourishing in subterranean ecosystems: Euro-Mediterranean Plusiocampinae and tachycampoids (Diplura, Campodeidae), pp. 1-138 in European Journal of Taxonomy 591 on page 21, DOI: 10.5852/ejt.2020.591, http://zenodo.org/record/3659823
Human Facial Expression Recognition Using Handcrafted Features and Deep Learning
Creators: name: Amin, Muhammad Usama
name: Zhimao, Lu
name: Wali, Muhammad Qasim
name: Rehman, Abdur
name: Naveed, Muhammad Usman
name: Ishaq, Muhammad Yasir
Publisher: name: Zenodo
Year: 2024

description: Recognition of facial expressions, a critical aspect of non-verbal social communication, plays an essential role in the field of Human-Computer Interaction (HCI). The development and application of both traditional handcrafted features and contemporary deep neural networks (DNNs) have substantially advanced the efficacy of Facial Expression Recognition (FER) systems. Enhancements in deep learning technologies have significantly improved the performance and efficiency of FER methodologies, rendering it an increasingly researched topic, particularly with the advent of streamlined neural network models. In this study, we introduced a framework designed to enhance the precision of Facial Expression Recognition (FER) by integrating sophisticated neural network-derived features with manually crafted features, including structural and appearance-based elements. Specifically, the handcrafted features employed encompass facial landmarks, Histograms of Oriented Gradients (HOG) — applicable with or without sliding window techniques — Local Binary Patterns (LBP), and Scale-Invariant Feature Transforms (SIFT). To effectively amalgamate these diverse features, the proposed model integrates a fully connected (FC) layer of CNN, facilitating the feature fusion of both the handcrafted and deep learning-derived features. Following this integration, the framework employs a CNN-based classification algorithm, which has been validated against benchmark datasets for effectiveness assessment. The evaluation protocol involved utilizing images of size 48 × 48 pixels to conduct tests and measure the performance of our proposed framework on several challenging datasets, notably FER2013 and the Extended Cohn-Kanade (CK+) datasets. According to the literature review, the presented framework exhibits a significant improvement in test accuracy over prevailing algorithms and methodologies within the domain. In the context of the FER2013 and Extended Cohn-Kanade (CK+) datasets, our system showcased superior performance. Specifically, it achieved accuracy rates of 66.5% and 99.8% across seven distinct emotional states, respectively. These results underscore the effectiveness and reliability of the proposed framework in accurately recognizing facial expressions.
Profiles of internalizing and externalizing symptoms associated with bullying victimization
Creators: name: Reyes, H.L.M.
name: Eastman, M.
name: North, K.E.
name: Foshee, V.
name: Faris, R.
name: Sotres-Alvarez, D.
name: Ennett, S.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: This study identified profiles of internalizing (anxiety and depression) and externalizing (delinquency and violence against peers) symptoms among bullying victims and examined associations between bullying victimization characteristics and profile membership. The sample consisted of 1196 bullying victims in grades 8–10 (Mage = 14.4, SD = 1.01) who participated in The Context Study in three North Carolina counties in Fall 2003. Five profiles were identified using latent profile analysis: an asymptomatic profile and four profiles capturing combinations of internalizing and externalizing symptoms. Associations between bullying characteristics and membership in symptom profiles were tested using multinomial logistic regression. More frequent victimization increased odds of membership in the two high internalizing profiles compared to the asymptomatic profile. Across all multinomial logistic regression models, when the high internalizing, high externalizing profile was the reference category, adolescents who received any type of bullying (direct, indirect, or dual) were more likely to be in this category than any others.
title: Comparative study of passive modelocking configurations in semiconductor lasers
Creators: name: Camacho Paez, Fernando
Publisher: name: University of Glasgow
Year: 1997
Subjects: subject: Electrical engineering.

description: This thesis is concerned with the investigation of different configurations of semiconductor lasers to generate short optical pulses through passive modelocking, and the analysis of the possible uses for these optical pulse generators. Three different modelocking configurations have been studied to generate optical pulses at frequencies between 1 and 15 GHz; two of them monolithic configurations, namely all active cavity mode-locked lasers and extended cavity mode-locked lasers and the third one being an external cavity configuration. The all active cavity mode-locked lasers have the advantage of having the easiest and most reliable fabrication process, but exhibited high threshold, around 100 mA for 5 mm long laser, broad pulses, around 10 ps, and high timing jitter levels, up to 22 ps (1 kHz-l0MHz). The extended cavity mode-locked lasers, which incorporate active and passive sections, are also easy to fabricate, but the reliability of the fabrication process depends on the reliability of the technique to fabricate the passive section of the device. They are excellent short pulse generators with very low threshold current, around 25 mA for a 5 mm long laser, pulses as narrow as 3.5 ps and jitter levels as low as 9 ps (1 kHz- 10MHz), which indicates a high stability in the pulse generation. With the external cavity configuration the pulse generation frequency can be reduced to values as low as hundreds of MHz. The drawback with this type of laser is their mechanical instability, which makes them a difficult device to work with. An important application for these optical pulse generators is that of all-optical clock recovery. The locking range of the monolithic configurations, under external periodic excitation, was studied. The all active cavity lasers showed a locking range wider than 0.15% of the free running modelocking frequency, whilst the extended cavity lasers locking range was around 0.03% of the free running modelocking frequency.
A high throughput, functional screen of human Body Mass Index GWAS loci using tissue-specific RNAi Drosophila melanogaster crosses
Creators: name: North, K.E.
name: Fink, J.L.
name: Cupples, L.A.
name: Liu, C.-T.
name: Kraja, A.T.
name: Borecki, I.B.
name: Baranski, T.J.
name: Lenzini, P.A.
name: Province, M.A.
name: Feitosa, M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2018

description: Human GWAS of obesity have been successful in identifying loci associated with adiposity, but for the most part, these are non-coding SNPs whose function, or even whose gene of action, is unknown. To help identify the genes on which these human BMI loci may be operating, we conducted a high throughput screen in Drosophila melanogaster. Starting with 78 BMI loci from two recently published GWAS meta-analyses, we identified fly orthologs of all nearby genes (± 250KB). We crossed RNAi knockdown lines of each gene with flies containing tissue-specific drivers to knock down (KD) the expression of the genes only in the brain and the fat body. We then raised the flies on a control diet and compared the amount of fat/triglyceride in the tissue-specific KD group compared to the driver-only control flies. 16 of the 78 BMI GWAS loci could not be screened with this approach, as no gene in the 500-kb region had a fly ortholog. Of the remaining 62 GWAS loci testable in the fly, we found a significant fat phenotype in the KD flies for at least one gene for 26 loci (42%) even after correcting for multiple comparisons. By contrast, the rate of significant fat phenotypes in RNAi KD found in a recent genome-wide Drosophila screen (Pospisilik et al. (2010) is ~5%. More interestingly, for 10 of the 26 positive regions, we found that the nearest gene was not the one that showed a significant phenotype in the fly. Specifically, our screen suggests that for the 10 human BMI SNPs rs11057405, rs205262, rs9925964, rs9914578, rs2287019, rs11688816, rs13107325, rs7164727, rs17724992, and rs299412, the functional genes may NOT be the nearest ones (CLIP1, C6orf106, KAT8, SMG6, QPCTL, EHBP1, SLC39A8, ADPGK /ADPGK-AS1, PGPEP1, KCTD15, respectively), but instead, the specific nearby cis genes are the functional target (namely: ZCCHC8, VPS33A, RSRC2; SPDEF, NUDT3; PAGR1; SETD1, VKORC1; SGSM2, SRR; VASP, SIX5; OTX1; BANK1; ARIH1; ELL; CHST8, respectively). The study also suggests further functional experiments to elucidate mechanism of action for genes evolutionarily conserved for fat storage.
title: Святой благоверный великий князь Александр Невский и его время
Creators: name: Ранне, Александр протоиререй
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: В статье дается очерк жизни и деятельности Александра Невского — в ипостасях князя, воина, политика. Показаны события и обстоятельства, сопутствующие его жизни и правлению. Описывается взаимодействие князя Александра Невского с иерархами католической церкви, русскими князьями, деятелями Золотой Орды. Проводится мысль, что целью и объединяющим мотивом поступков и деятельности Александра Невского были его забота о благополучии Русской земли, следование идеалам Православной церкви.
GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation
Creators: name: Moss, K.L.
name: Jing, L.
name: North, K.E.
name: Seaman, W.T.
name: Beck, J.D.
name: Offenbacher, S.
name: Schaefer, A.S.
name: Cowley, D.
name: Agler, C.S.
name: Jiao, Y.
name: Sun, L.
name: Barros, S.P.
name: Zhang, S.
name: Kim, S.J.
name: Divaris, K.
name: Marchesan, J.
name: Bencharit, S.
name: Morelli, T.
name: Munz, M.
Publisher: name: Nature Publishing Group
Year: 2018

description: There is no agnostic GWAS evidence for the genetic control of IL-1β expression in periodontal disease. Here we report a GWAS for “high” gingival crevicular fluid IL-1β expression among 4910 European-American adults and identify association signals in the IL37 locus. rs3811046 at this locus (p = 3.3 × 10−22) is associated with severe chronic periodontitis (OR = 1.50; 95% CI = 1.12–2.00), 10-year incident tooth loss (≥3 teeth: RR = 1.33; 95% CI = 1.09–1.62) and aggressive periodontitis (OR = 1.12; 95% CI = 1.01–1.26) in an independent sample of 4927 German/Dutch adults. The minor allele at rs3811046 is associated with increased expression of IL-1β in periodontal tissue. In RAW macrophages, PBMCs and transgenic mice, the IL37 variant increases expression of IL-1β and IL-6, inducing more severe periodontal disease, while IL-37 protein production is impaired and shows reduced cleavage by caspase-1. A second variant in the IL37 locus (rs2708943, p = 4.2 × 10−7) associates with attenuated IL37 mRNA expression. Overall, we demonstrate that IL37 variants modulate the inflammatory cascade in periodontal disease.
New Zealand nurses' alcohol and other drug use
Creators: name: Topp, Marea
Publisher: name: Charles Darwin University
Year: 2016

description: This study is the first New Zealand research to estimate the prevalence of nurses’ alcohol and other drug use (AOD). It is also the first study to examine the implications of altered work performance due to AOD use. A mixed methods design was used. This included developing a questionnaire and surveying a nationally representative sample of active registered nurses. In addition, to gain a greater depth of understanding of the survey findings, focus groups and individual interviews were undertaken with active registered nurses, managers of nurses and Directors of Nursing across rural, regional and metropolitan regions. This research found that nurses’ use of alcohol was similar to that reported for the New Zealand general population. Nurses’ cannabis use was less than reported for the general population and their opiate and benzodiazepine use was two times greater. When nurses reported working below their normal level of performance due to their AOD use, their critical thinking and decision making abilities were altered, and they neglected the emotional care of patients and families. Nurse colleagues accommodated AOD affected nurses’ behaviours in an effort to reduce risk to both patients and the affected nurses. The findings from this study suggest an established ‘culture of permissibility’ that unintentionally enables nurses to compromise the safety of patients when they work with a hangover or when they work while affected by their AOD use. It is recommended AOD workforce education be provided to nurses and nursing students and organisational policies be developed that include zero tolerance for nurses working with a hangover, or otherwise affected by AOD use. These processes would discourage the continuation of the culture of permissibility, reduce health service provider organisations’ risk, and promote safe patient care.
Objectively measured physical activity, sedentary behavior, and genetic predisposition to obesity in U.S. Hispanics/Latinos: Results from the hispanic community health study/study of Latinos (HCHS/SOL)
Creators: name: Gellman, M.D.
name: Argos, M.
name: Sotres-Alvarez, D.
name: Wang, T.
name: Kaplan, R.C.
name: North, K.E.
name: Sofer, T.
name: Qi, Q.
name: Moon, J.-Y.
name: Isasi, C.R.
name: Cai, J.
name: Moncrieft, A.E.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Studies using self-reported data suggest a gene-physical activity interaction on obesity, yet the influence of sedentary behavior, distinct from a lack of physical activity, on genetic associations with obesity remains unclear. We analyzed interactions of accelerometer-measured moderate to vigorous physical activity (MVPA) and time spent sedentary with genetic variants on obesity among 9,645 U.S. Hispanics/Latinos. An overall genetic risk score (GRS), a central nervous system (CNS)-related GRS, and a non-CNS-related GRS were calculated based on 97 BMIassociated single nucleotide polymorphisms (SNPs). Genetic association with BMI was stronger in individuals with lower MVPA (first tertile) versus higher MVPA (third tertile) (b = 0.78 kg/m2 [SE, 0.10 kg/m2] vs. 0.39 kg/m2 [0.09 kg/m2] per SD increment of GRS; Pinteraction = 0.005), and in those with more time spent sedentary (third tertile) versus less time spent sedentary (first tertile) (b = 0.73 kg/m2 [SE, 0.10 kg/m2] vs. 0.44 kg/m2 [0.09 kg/m2]; Pinteraction = 0.006). Similar significant interaction patterns were observed for obesity risk, body fat mass, fat percentage, fat mass index, and waist circumference, but not for fat-free mass. The CNS-related GRS, but not the non-CNS-related GRS, showed significant interactions with MVPA and sedentary behavior, with effects on BMI and other adiposity traits. Our data suggest that both increasing physical activity and reducing sedentary behavior may attenuate genetic associations with obesity, although the independence of these interaction effects needs to be investigated further.
title: Мужество защитников Сталинграда в художественном освещении Константина Симонова: повесть «Дни и ночи» (1944)
Creators: name: Алексеева, Любовь
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: Освещаются художественные и документально-исторические достоинства написанной молодым, еще не достигшим 30-летия Симоновым повести о переломной для хода войны битве за Сталинград. Сама эпоха предстает со страниц повести в ее подробностях, удивительных для современного читателя, представляющих многие особенности отношений между защитниками города, в том числе жёсткую субординацию, суровую дисциплину; их самоотверженность, горькие переживания и мужественные поступки. С особой пронзительностью включается в трагическое пространство любовная история, высвечивающая понимание персонажами смысла жизни, светлую сущность бытия.
Isolation and evaluation of cytogenetic effect of Brahmi saponins on cultured human lymphocytes exposed in vitro
Creators: name: Mangathayaru Kalachaveedu
name: Sunu Papacchan
name: Sudip Sanyal
name: Koshy, Teena
name: Srivani Telapolu
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 60506 Virology
subject: FOS: Biological sciences
subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Science Policy
subject: Cancer
subject: Biological Sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Physiology
subject: Molecular Biology
subject: Genetics
subject: Cell Biology
subject: Microbiology
subject: Biochemistry

description: Major saponins of Brahmi (Bacopa monniera, Fam: Scrophulariaceae) – bacosides A and B – were isolated from the total methanol extract and characterised based on melting point, TLC, IR, 1H NMR and 13C NMR. They were evaluated for their in vitro cytogenetic effects on human peripheral blood lymphocytes by chromosomal aberration (CA) assay and sister chromatid exchange (SCE) assay. The frequency of chromatid type aberrations and reciprocal interchanges between sister chromatids in the treated cells was scored in comparison to the untreated control. At 30 μg/mL dose, bacoside A showed a statistically significant increase in the frequency of both CA and SCE and bacoside B showed an increase only in SCE. Our report of the genotoxicity of the saponins is significant in view of the reports of anticancer activity of Brahmi extracts.
Gene-by-psychosocial factor interactions influence diastolic blood pressure in european and african ancestry populations: Meta-analysis of four cohort studies
Creators: name: North, K.E.
name: Boerwinkle, E.
name: Yasutake, K.
name: Mwasongwe, S.
name: Sims, M.
name: Sun, Y.V.
name: Needham, B.L.
name: Zhao, W.
name: Weir, D.R.
name: Gao, Y.
name: Smith, J.A.
name: August, C.
name: Roux, A.V.D.
name: Heiss, G.
name: Kardia, S.L.R.
name: Griswold, M.E.
name: Chakravarti, A.
name: Ratliff, S.M.
name: Morrison, A.C.
name: Faul, J.D.
name: Musani, S.K.
name: Rose, K.M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2017

description: Inter-individual variability in blood pressure (BP) is influenced by both genetic and nongenetic factors including socioeconomic and psychosocial stressors. A deeper understanding of the gene-by-socioeconomic/psychosocial factor interactions on BP may help to identify individuals that are genetically susceptible to high BP in specific social contexts. In this study, we used a genomic region-based method for longitudinal analysis, Longitudinal Gene-Environment-Wide Interaction Studies (LGEWIS), to evaluate the effects of interactions between known socioeconomic/ psychosocial and genetic risk factors on systolic and diastolic BP in four large epidemiologic cohorts of European and/or African ancestry. After correction for multiple testing, two interactions were significantly associated with diastolic BP. In European ancestry participants, outward/trait anger score had a significant interaction with the C10orf107 genomic region (p = 0.0019). In African ancestry participants, depressive symptom score had a significant interaction with the HFE genomic region (p = 0.0048). This study provides a foundation for using genomic region-based longitudinal analysis to identify subgroups of the population that may be at greater risk of elevated BP due to the combined influence of genetic and socioeconomic/psychosocial risk factors.
In vitro antioxidant, antimicrobial and anti-proliferative activities of purple potato extracts (Solanum tuberosum cv Vitelotte noire) following simulated gastro-intestinal digestion
Creators: name: Ombra, Maria Neve
name: Fratianni, Florinda
name: Granese, Tiziana
name: Cardinale, Federica
name: Autilia Cozzolino
name: Nazzaro, Filomena
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Cancer
subject: Developmental Biology
subject: Information and Computing Sciences
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Microbiology
subject: Biochemistry

description: Analyses of antioxidant and in vitro antimicrobial and anti-proliferative activities of anthocyanin-rich extracts from purple potatoes, Solanum tuberosum L. cv Vitelotte noire (Solanaceae), were performed by simulating both a domestic cooking process and human digestion. Extracts of crude and cooked purple potato did not exhibit antimicrobial activity against the tester strains: Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa. The behaviour changed after the simulated gastrointestinal transit, when an inhibition halo was observed against all tester strains used, ranging from 0.53 cm against B. cereus to 0.82 cm against E. coli. In addition antioxidant activity exhibited, before and after the simulated gastrointestinal digestion (5.96 mg/mL ± 0.92; 28 mg/mL ± 0 .13, respectively) and the persistence of anti-proliferative activity against the colon cancer cells Caco-2, SW48 and MCF7, MDA-MB-231 breast cancer cells, after the simulated digestion, (EC50 = 0.21; 1.13 μg/mL), suggest that vitelotte consumption might bring tangible benefits for human health.
Assessment of mineral elements and heavy metals in leaves of indigenous cypress of High Atlas Mountains
Creators: name: M.Y. Arjouni
name: M.A. Bennouna
name: M.A. El Alaoui El Fels
name: A. Romane
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Hematology
subject: Biological Sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Biochemistry
subject: Biophysics

description: An inductively coupled plasma mass spectrometry was developed to determine 20 mineral elements and heavy metals in leaves of Cupressus atlantica Gaussen, a traditional Moroccan medicinal herb from five environmentally different sites in N'Fis valley (High Atlas Mountains). The results showed in the leaves that Ca, K, P, Mg, Na and Fe were the most abundant of the elements in all samples of the studied locality. The concentrations of trace metals from the leaves of this plant were in the order Ca>K > P > Mg>Na>Fe. The results of the mineral composition were analysed by hierarchical cluster and principal component analysis that established three statistically significant clusters.
Process optimisation for the biosynthesis of cellulase by Bacillus PC-BC6 and its mutant derivative Bacillus N3 using submerged fermentation
Creators: name: Roheena Abdullah
name: Wajeeha Zafar
name: Nadeem, Muhammad
name: Mehwish Iqtedar
name: Shagufta Naz
name: Quratulain Syed
name: Afshan Kaleem
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: 110309 Infectious Diseases
subject: FOS: Health sciences
subject: Ecology
subject: FOS: Biological sciences
subject: Earth and Environmental Sciences
subject: Biotechnology
subject: Molecular Biology
subject: Microbiology
subject: Biochemistry

description: This study deals with optimisation of cultural conditions for enhanced production of cellulase by Bacillus PC-BC6 and its mutant derivative Bacillus N3. Influence of different variables including incubation time, temperature, inoculum size, pH, nitrogen sources and metal ions has been studied. The optimum conditions for cellulase production were incubation period of 72 h, inoculum size 4% incubation temperature 37°C, pH 7, 0.25% ammonium sulphate, 0.2% peptone as inorganic and organic nitrogen source in case of Bacillus PC-BC6. In case of mutant Bacillus N3, optimal conditions were incubation period of 48 h, incubation temperature 37°C, inoculum size 3%, pH 7, 0.2% ammonium chloride and 0.15% yeast extract. Presence of MnSO4 and CaCl2 enhances the enzyme production by Bacillus PC-BC6 and mutant Bacillus N3, respectively. This study was innovative and successful in producing cellulase economically by using cheap indigenous substrate Saccharum spontaneum.
New flavonol glycosides from the leaves of Caragana brachyantha
Creators: name: Shagufta Perveen
name: Areej Mohammad Al-Taweel
name: Al-Musayeib, Nawal
name: Fawzy, Ghada Ahmed
name: Khan, Afsar
name: Mehmood, Rashad
name: Malik, Abdul
Publisher: name: Taylor & Francis
Year: 2015
Subjects: subject: Science Policy
subject: Developmental Biology
subject: Biological Sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Ecology
subject: FOS: Biological sciences
subject: Chemistry
subject: Earth and Environmental Sciences
subject: Molecular Biology
subject: Genetics
subject: Microbiology
subject: Engineering
subject: Biochemistry

description: Two new flavonol glycosides, brachysides C and D, together with three known flavonol glycosides, were isolated from the leaves of Caragana brachyantha. The structures of brachysides C and D were elucidated on the basis of detailed spectroscopic analysis as quercetin 5-O-[α-l-rhamnopyranosyl-(1 → 6)-β-d-glucopyranoside]-7-O-[α-l-rhamnopyranoside] and quercetin 5-O-[α-l-rhamnopyranosyl-(1 → 6)-β-d-glucopyranoside]-7-O-[α-l-rhamnopyranoside]-4′-O-[α-l-rhamnopyranoside], respectively. The presence of flavonol tetra- and triglycosides bearing a sugar moiety at position 5 was the first report from this genus Caragana.
Feasibility and efficacy of early docetaxel plus androgen deprivation therapy for metastatic hormone-sensitive prostate cancer in a rural health care setting
Creators: name: Nieder, Carsten
name: Stanisavljevic, Luka
name: Dalhaug, Astrid
name: Haukland, Ellinor
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Medicine
subject: Biotechnology
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: FOS: Biological sciences
subject: Cancer
subject: Science Policy

description: The aim of this study was to evaluate the feasibility and efficacy, in terms of overall survival, of intensified upfront systemic therapy in patients with metastatic hormone-sensitive prostate cancer who lived in rural Nordland County, Norway. Overall 117 patients were included in this retrospective study. Three cohorts were created: early docetaxel and androgen deprivation therapy (ADT; the CHAARTED regimen; n = 37), ADT only during the same time period (2014–2020; n = 33), and ADT only in the years 2009–2014 (n = 47). Four patients (11%) did not complete 6 cycles of docetaxel, one of these due to early progression of cancer. During follow-up, 8 patients (22%) progressed to castration-resistant disease (mCRPC), compared to 24 (73%) with ADT only and 35 (75%) in the historical cohort, p = 0.000001. Such progression occurred within 12 months in 3 patients (8%) treated with docetaxel and 9 patients (27%) treated with ADT only during the same time period, p = 0.05. Median survival was 56 months (95% CI: 40–72 months), compared to 30 months in both other cohorts. 3-year survival rates were 79%, 38% and 37%, respectively (p = 0.016). In multivariate analysis, the CHAARTED regimen was associated with significantly improved survival. In this rural health care setting, early docetaxel was feasible and effective in reducing progression to mCRPC and prolonging survival. Median survival was very close to the 58 months reported in the CHAARTED trial.
The novel ASIC2 locus is associated with severe gingival inflammation
Creators: name: North, K.E.
name: Marchesan, J.
name: Offenbacher, S.
name: Wu, D.
name: Zhang, S.
name: Moss, K.
name: Beck, J.
name: Barros, S.
name: Kim, S.J.
name: Agler, C.
name: Morelli, T.
name: Yu, N.
name: Divaris, K.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2016

description: An increasing body of evidence suggests a significant genetic regulation of inflammatory response mechanisms; however, little is known regarding the genetic determinants of severe gingival inflammation (GI). We conducted a genomewide association study of severe GI among 4,077 European American adults, participants in the Dental Atherosclerosis Risk in Communities cohort. The severe GI trait was defined dichotomously with the 90th percentile of gingival index ≥2 extent score. Genotyping was performed with the Affymetrix 6.0 array platform, and an imputed set of 2.5 million markers, based on HapMap Phase II CEU build 36, was interrogated. Genetic models were based on logistic regression and controlled for ancestry (10 principal components), sex, age, and examination center. One locus on chromosome 17 met genomewide statistical significance criteria—lead single-nucleotide polymorphism: rs11652874 (minor allele frequency = 0.06, intronic to ASIC2 [acidsensing ionic channel 2, formerly named ACCN1]; odds ratio = 2.1, 95% confidence interval = 1.6 to 2.7, P = 3.9 × 10-8). This association persisted among subjects with severe periodontitis and was robust to adjustment for microbial plaque index. Moreover, the minor (G) allele was associated with higher levels of severe GI in stratified analyses among subsets of participants with high load of either “red” or “orange” complex pathogens, although this association was not statistically significant. While these results will require replication in independent samples and confirmation by mechanistic studies, this locus appears as a promising candidate for severe GI. Our findings suggest that genetic variation in ASIC2 is significantly associated with severe GI and that the association is plaque independent. Knowledge Transfer Statement: Persistent gingival inflammation reflected by bleeding usually precedes ongoing attachment loss or periodontal disease progression. Our findings suggest that genetic variation in ASIC2 that is associated with severe gingival inflammation might be used as a genetic marker to identify people at higher risk for periodontal disease. Ongoing studies to uncover the mechanistic link between ASIC2 and gingival inflammation could lead to novel therapeutic interventions.
IGSN – More than Unique Identification of Samples
Creators: name: Lehnert, Kerstin
name: Elger, Kirsten
name: Ulbricht, Damian
Publisher: name: Zenodo
Year: 2020
Subjects: Physical Samples
IGSN
FAIR
Data Publication

description: Introduction to IGSN, with a focus on GFZ/Germany.
Genome Organization
Creators: name: Garg, HK
Publisher: name: Zenodo
Year: 2022
Subjects: Genome
Plant Genome
Animal Genome
Viral Genome
Genetic Engineering

description: The human genome is a complex design of life, composed of billions of base pairs intricately organized within our cells. It is not just a simple sequence of DNA, but a sophisticated structure packed with layers of information that guide every cellular process.

In man, the genome consists of 23 pairs of chromosomes, each packed with thousands of genes that code for proteins - the building blocks of life. But genome organization goes beyond the linear arrangement of genes. It directly influences genetic activity. Regions of tightly packed chromatin, known as heterochromatin, are often inactive, while more loosely packed areas, or euchromatin, allow genes to be more easily accessed and expressed. This dynamic organization is essential for cellular differentiation, development, and response to external cues.