cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Hydrostatic and chemical pressure driven crossover from commensurate to the incommensurate state of the Weyl semimetal Mn$_{3+x}$Sn$_{1-x}$
Creators: name: Bhattacharya, K.
name: Bharatwaj, A. K.
name: Singh, C.
name: Gupta, R.
name: Khasanov, R.
name: Kanungo, S.
name: Nayak, A. K.
name: Majumder, M.
Publisher: name: arXiv
Year: 2024
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: The observation of large intrinsic anomalous Hall conductivity (AHC) in the non-collinear antiferromagnetic (AFM) phase of the Weyl semimetal Mn$_3$Sn generates enormous interest in uncovering the entanglement between the real space magnetic ordering and the momentum space band structure. Previous studies show that changes in the magnetic structure induced by the application of hydrostatic and chemical pressure can significantly affect the AHC of Mn$_{3+x}$Sn$_{1-x}$ system. Here, we employ the muon spin relaxation/rotation ($μ^+$SR) technique to systematically investigate the evolution of different magnetic states in the Mn$_{3+x}$Sn$_{1-x}$ as a function of hydrostatic and chemical pressure. We find two muon sites experimentally, which is also supported by our \textit{ab initio} calculations. Our $μ^+$SR experiments affirm that the $x = 0.05$ compound exhibits a commensurate magnetic state throughout the magnetically ordered phase below the Neel temperature $T_N \approx 420$~K in ambient pressure. In contrast, we observe an incommensurate magnetic state below $T_{IC} \sim 175$~K when a hydrostatic pressure of 1.5~GPa is applied. A similar transition from the commensurate to incommensurate state is also found with chemical pressure for $x = 0.04$ and $x = 0.03$, using $μ^+$SR and elastic neutron scattering experiments. Using band structure calculations, we have shown the emergence of Fermi nesting in Mn$_3$Sn and the subsequent development of incommensurate magnetic ordering under hydrostatic/chemical pressure.
description: 13 pages, 8 figures. Accepted at Physical Review B (2024)
A library of electrophysiological responses in plants - A model of transversal education and open science: Source Data Recordings and Supplemental Figure 1
Creators: name: Madariaga, Danae
name: Arro, Derek
name: Irarrázaval, Catalina
name: Soto, Alejandro
name: Guerra, Felipe
name: Romero, Angélica
name: Ovalle, Fabián
name: Fedrigolli, Elsa
name: DesRosiers, Thomas
name: Serbe-Kamp, Étienne
name: Marzullo, Timothy C.
Publisher: name: figshare
Year: 2024
Subjects: classificationCode: 310806
subject: Plant physiology

description: A .zip file containing all electrophysiology recordings for this study + supplemental figure 1.Online ResourcesTo generate the figures Fig. 3 and Suppl. Fig. 1, we used the following code base: t.ly/dJBGcTo generate Fig. 4 (conduction velocity in Drosera), we used the following code base: t.ly/HRdQAThe online data from all recordings is stored in the following library: t.ly/imDXRNew data can be sent also through Google Forms: t.ly/LbTTI
Interaction of radiopharmaceutical with SSTR2 revealed by MD simulations
Creators: name: Silvia, Gervasoni
name: Işılay, Öztürk
name: Camilla, Guccione
name: Andrea, Bosin
name: Paolo, Ruggerone
name: Giuliano, Malloci
Publisher: name: Zenodo
Year: 2023

description: The development of drugs targeting the somatostatin receptor 2 (SSTR2), generally overexpressed in neuroendocrine tumors, is the focus of intense research. A few molecules in conjugation with radionuclides are in clinical use for both diagnostic and therapeutic purposes. These radiopharmaceuticals are composed by a somatostatin analogue bio-vector conjugated to a chelator moiety bearing the radionuclide. To date, despite valuable efforts, a detailed molecular-level description of the interaction of radiopharmaceuticals in complex with SSTR2 has not yet been accomplished. Therefore, in this work we carefully analyzed the key dynamical features and detailed molecular interactions of SSTR2 in complex with six radiopharmaceutical compounds selected among the few already in use (64Cu/68Ga-DOTATATE, 68Ga-DOTATOC, 64Cu-SARTATE) and some in clinical development (68Ga-DOTANOC, 64Cu-TETATATE). Through molecular dynamics simulations exploiting recently available structures of SSTR2, we explored the influence of the different portions of the compounds (peptide, radionuclide, chelator) in the interaction with the receptor. We identified the most stable binding modes and found distinct interaction patterns characterizing the six compounds. We thus unveiled detailed molecular interactions crucial for recognition of this class of radiopharmaceuticals. The microscopically well-founded analysis presented in this study provides guidelines to the design of new potent ligands targeting SSTR2.
description: Molecular dynamics (MD) simulations of the somatostatin receptor 2 in complex with six radiopharmaceuticals: 68Ga/64Cu-DOTATATE, 68Ga-DOTATOC, 68Ga-DOTANOC, 64Cu-TETATATE, 64Cu-SARTATE. For each system, five replicas of 3 microsecond-long MD simulations were performed. Here we report the raw MD simulations (production runs), stripped every five frames and without solvent, in the compressed "xtc" format. The input topology and coordinates files (parm7 and rst7) of the systems are included, as well as the conformational clusters (pdb).
description: {"references": ["Gervasoni, S., Guccione, C., Fanti, V. et al. Molecular simulations of SSTR2 dynamics and interaction with ligands. Sci Rep 13, 4768 (2023). https://doi.org/10.1038/s41598-023-31823-1"]}
Brief interventions for alcohol misuse among people living with HIV: a meta-analysis
Creators: name: Ghosh, Abhishek
name: Singh, Geetesh K.
name: Yadav, Nidhi
name: Singh, Pranshu
name: Kathiravan, Sanjana
Publisher: name: Taylor & Francis
Year: 2023
Subjects: subject: Medicine
subject: Biotechnology
subject: Science Policy
subject: Mental Health
subject: Infectious Diseases
subject: FOS: Health sciences
subject: Virology

description: Background: One-third of people living with HIV (PLHIV) have alcohol misuse or alcohol use disorders which negatively affect course and outcome of HIV. Objectives: The meta-analysis sought to evaluate the effectiveness of brief interventions (BI) on alcohol and HIV outcomes in PLHIV with alcohol misuse. Methods: We included clinical trials published between 1990 and September 2022 on adults with harmful/hazardous alcohol use; only randomized clinical trials (RCTs) were included in the meta-analysis. We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Clinical Trials.Gov, and the World Health Organization’s International Clinical Trials Registry Platform databases. Cochrane’s risk-of-bias assessment was used. Results: Eighteen studies were included in the narrative synthesis, and a meta-analysis could be performed on 13 studies. Among the included RCTs, seven showed a low risk and two showed a high risk of bias; others showed some concerns. There was no evidence of publication bias. Compared to the control, BI significantly reduces the drinks per drinking day (N = 5, Hedge’s g= −0.45, 95%CI = −0.58, −0.32) and the number of heavy drinking days (N = 4, Hedge’sg = −0.81, 95% CI= −0.94, −0.67) between 3–6 months post-intervention. BI also reduces the odds of mortality by 42% (N = 7, OR = 0.58, 95% CI = 0.34, 0.99) in 6–12 months. BI does not change the alcohol risk scores and transition to harmful alcohol use; it does not improve adherence to Anti-Retroviral Therapy and increase viral suppression. Conclusion: Policymakers must introduce and scale up integrated screening and brief intervention services within HIV clinics and primary care.
Prevalence and correlates of DSM-5 opioid withdrawal syndrome in U.S. adults with non-medical use of prescription opioids: results from a national sample
Creators: name: Mannes, Zachary L.
name: Livne, Ofir
name: Knox, Justin
name: Hasin, Deborah S.
name: Kranzler, Henry R.
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biotechnology
Biological Sciences not elsewhere classified
Science Policy
Mental Health

description: Background: In the U.S. non-medical use of prescription opioids (NMOU) is prevalent and often accompanied by opioid withdrawal syndrome (OWS). OWS has not been studied using nationally representative data. Objectives: We examined the prevalence and clinical correlates of OWS among U.S. adults with NMOU. Methods: We used data from 36,309 U.S. adult participants in the 2012–2013 National Epidemiologic Survey on Alcohol and Related Conditions-III, 1,527 of whom reported past 12-month NMOU. Adjusted linear and logistic regression models examined associations between OWS and its clinical correlates, including psychiatric disorders, opioid use disorder (OUD; excluding the withdrawal criterion), medical conditions, and healthcare utilization among people with regular (i.e. ≥3 days/week) NMOU (n = 534). Results: Over half (50.4%) of the sample was male. Approximately 9% of people with NMOU met criteria for DSM-5 OWS, with greater prevalence of OWS (∼20%) among people with regular NMOU. Individuals with bipolar disorder, dysthymia, panic disorder, and borderline personality disorder had greater odds of OWS (aOR range = 2.71–4.63). People with OWS had lower mental health-related quality of life (β=-8.32, p < .001). Individuals with OUD also had greater odds of OWS (aOR range = 26.02–27.77), an association that increased with more severe OUD. People using substance use-related healthcare services also had greater odds of OWS (aOR range = 6.93–7.69). Conclusion: OWS was prevalent among people with OUD and some psychiatric disorders. These findings support screening for OWS in people with NMOU and suggest that providing medication- assisted treatments and behavioral interventions could help to reduce the burden of withdrawal in this patient population.
Embodiment and emergent phonology in the visual-manual modality : factors enabling sublexical componentiality
Creators: name: Tkachman, Oksana
Publisher: name: University of British Columbia
Year: 2022

description: Duality of patterning, which refers to the fact that in languages a limited number of meaningless units combine to create an unlimited number of meaningful units, is considered a language design feature, a property that any human language is expected to have. However, some emerging sign languages have been claimed to lack this property, and some research on spoken languages suggests that it is a strong statistical tendency rather than a universal property of human language. In this dissertation, I explore the possibility that duality of patterning is an emergent property, and it is so widespread because some commonality of human communication motivates its emergence repeatedly, across languages of different types and even modalities. I argue that this commonality is the human body. I adopt the Embodied Cognition framework, which views the body as integral to cognitive processing via the sensorimotor systems that are active not only in action but also in mental imagery and conceptual representation. It views cognition as emergent from embodied experiences of the sensorimotor system, perception, and interaction with the environment. “Abstract” properties of higher cognition are epiphenomenal to the lower-level habitual functioning of bodies in their environments, which is true of language as well. One way to understand how duality of patterning could emerge phylogenetically is via iconicity; iconicity is claimed to be a bridge between language and sensorimotor experiences. I argue that meaningless sublexical componentiality develops as a consequence of the emergence and conventionalization of meaningful sublexical componentiality. We should expect the emergence of meaningful sublexical componentiality in phylogenesis, because we are embodied creatures, and both the content and the form of our communicative messages are motivated and constrained by the structure and kinematics of our bodies. If both the content and the form of the message are embodied, we should expect to find effects of embodiment both in the iconic prototypes chosen to create an iconic sign, and in the phonetic form of a sign. Therefore, I explore the role of two factors, iconicity and kinematics, in contributing to the emergence of a conventionalized inventory of meaningful sublexical segments in the visual-manual modality.
Obtaining Green Energy From Municipal Wastewater Treatment Plants With Environmentally Friendly And Energy-Efficient Technologies
Creators: name: Abbas, Gursel
name: Yuksel Orhan, Ozge
Publisher: name: figshare
Year: 2023
Subjects: Chemical and thermal processes in energy and combustion
Waste management, reduction, reuse and recycling

description: Waste management is crucial in addressing environmental pollution and public health concerns. A study used chemical looping combustion (CLC) to process waste sludge from the Ankara Central Wastewater Treatment Plant and red mud from Eti Aluminum as an oxygen carrier. Analytical methods showed the red mud's suitability as an oxygen carrier, resulting in zero emissions. Waste sludge was found to have an energy value similar to brown coal, and the ash produced could be used in cement and fertilizer production. This novel technology provides a zero-waste and zero-carbon footprint approach to waste management, helping to reduce environmental impacts.
Pipeline mesh generator based on blockMesh version 2.5
Creators: name: Polansky, Jiri
Publisher: name: Physikalisch-Technische Bundesanstalt (PTB)
Year: 2023
Subjects: Mesh generation
pipelines
T-junctions
elbows
hexahedral mesh
OpenFOAM
blockMesh

description: This report provides a description of an OpenFOAM script for constructing fully hexahedral meshes for a variety of different pipeline geometries. This script allows to change several length scales as well as some useful geometrical parameters concerning the refinement of the mesh, for example close to the walls to resolve boundary layers. The aim of the mesh generator tool is to extent the blockMesh utility in such a way that it allows to create arbitrary geometries consisting of bends, blind-Ts, Venturi parts, and straight pipes. For the different parts, the following parameters can be adapted to the considered geometry: • Bend: diameter of the pipe, radius of curvature, orientation in space • Blind-T: diameter of inflow pipe, diameter of outflow pipe, length of blind end, orientation in space • Venturi part: inlet diameter, throat diameter, outlet diameter, convection angle, divergence angle, orientation in space • Straight pipe: diameter of pipe, orientation in space. Furthermore, one can prescribe the number of nodes used in flow direction, in radial direction as well as within the boundary layer.
Meta-analysis of primary care delivered buprenorphine treatment retention outcomes
Creators: name: Cooper, Robert L.
name: Edgerton, Ryan D.
name: Watson, Julia
name: Conley, Nicholas
name: Agee, William A.
name: Wilus, Derek M.
name: MacMaster, Samuel A.
name: Bell, Lisa
name: Patel, Parul
name: Godbole, Amruta
name: Bass-Thomas, Cynthia
name: Ramesh, Aramandla
name: Tabatabai, Mohammad
Publisher: name: Taylor & Francis
Year: 2023
Subjects: Biochemistry
Pharmacology
Biotechnology
Cancer
Science Policy
Mental Health

description: Background: Currently, the capacity to provide buprenorphine treatment (BT) is not sufficient to treat the growing number of people in the United States with opioid use disorder (OUD). We sought to examine participant retention in care rates of primary care delivered BT programs and to describe factors associated with retention/attrition for participants receiving BT in this setting. Objectives: A PRISMA-guided search of various databases was performed to identify the articles focusing on efficacy of BT treatment and OUD. Method: A systematic literature search identified 15 studies examining retention in care in the primary care setting between 2002 and 2020. Random effects meta-regression were used to identify retention rates across studies. Results: Retention rates decreased across time with a mean 0.52 rate at one year. Several factors were found to be related to retention, including: race, use of other drugs, receipt of counseling, and previous treatment with buprenorphine. Conclusions: While we only investigate BT through primary care, our findings indicate retention rates are equivalent to the rates reported in the specialty care literature. More work is needed to examine factors that may impact primary care delivered BT specifically and differentiate participants that may benefit from care delivered in specialty over primary care as well as the converse.
title: L'aromathérapie comme intervention infirmière
title: l'huile essentielle de lavande pour soulager les souffrances de l'anxiété
titleType: Subtitle
title: L'aromathérapie comme intervention infirmière
titleType: AlternativeTitle
Creators: name: Ulveling, Quentin
Publisher: name: Unknown
Year: 0
Subjects: subject: Aromathérapie
subject: Gestion des émotions
subject: Soins infirmiers

description: Question de recherche : quel est l’impact de l’utilisation de l’huile essentielle de lavande (sous différentes formes) dans la prise en charge de l’anxiété chez l’adulte hospitalisé comparée à son absence et au placébo ? Contexte : en 2017, environ une personne sur six a été hospitalisée en Suisse et cet environnement hospitalier est souvent anxiogène. L’aromathérapie est proposée comme intervention infirmière dans le Nursing Interventions Classification (NIC), et le Manuel de diagnostics infirmiers « Carpenito » propose de renseigner le patient sur l’aromathérapie comme technique de relaxation lorsqu’il souffre d’anxiété (Butcher, Bulechek, Dochterman, & Wagner, 2018, p. 72 ; Carpenito, 2016, p. 79). Pourtant, l’aromathérapie est un sujet vaste qui demande des précisions sur l’huile essentielle à utiliser pour ce symptôme spécifique, son efficacité ou encore sur les recommandations associées pour la pratique, entre autres.
Endoluminal stent reconstruction of low-grade, symptomatic carotid plaques: a treatment alternative—report of two cases
Creators: name: Zeenat Qureshi Stroke Institutes
Publisher: name: Zenodo
Year: 2023

description: Introduction—Medical treatment of low-grade (<50% luminal narrowing) symptomatic carotid stenosis has been the treatment of choice because trial data showed no evident benefit to carotid endarterectomy for these patients. Such patients may have recurrent neurological symptoms despite adequate medical therapy owing to recurrent plaque rupture. In such cases, carotid stenting may represent an option for treatment but has not been tested in trials because of previous failure of carotid endarterectomy to demonstrate any benefit for patients with low-grade carotid stenosis. The cases presented here illustrate the perioperative safety and potential benefit of carotid stenting for such patients with persistent neurological symptoms despite adequate medical therapy. Case material—Two patients with low-grade stenosis and recurrent transient ischemic attack or stroke despite antiplatelet therapy were treated with carotid stenting. Both patients were treated after recent ipsilateral neurological events in the absence of an evident cardioembolic source. Carotid plaque ulceration thought to be related to the ischemic events was present in both cases. No perioperative complications were noted. On followup, the patients showed resolution of symptoms and had no new neurological events. Conclusion—Carotid stenting of low-grade but symptomatic carotid plaque refractory to medical management represents a surgical option for treatment. Further studies may be warranted to evaluate stenting as a suitable treatment option.
title: Stratégies utilisées par les infirmier.ère.s aux urgences pour offrir des transmissions de qualité
title: Stratégies utilisées par les infirmier.ère.s aux urgences pour offrir des transmissions de qualité
titleType: AlternativeTitle
Creators: name: Steiner, Aurélie
Publisher: name: Unknown
Year: 0
Subjects: subject: Transmission d'information
subject: Qualité des soins
subject: Urgences

description: La question de recherche de ce travail de Bachelor consiste à déterminer les stratégies développées par les infirmier.ère.s pour assurer des transmissions de qualité dans les services d’urgences. Les transmissions sont un sujet très discuté concernant la sécurité du patient au vu de l’importance que prend la communication dans les événements indésirables. Le fonctionnement du système hospitalier actuel a provoqué un fractionnement dans le parcours du patient ce qui met à mal la continuité des soins. De plus, les changements de responsabilités ainsi que les brèches dans l’activités d’un.e infirmier.ère qui a plusieurs patients à sa responsabilité provoquent de nombreuses ruptures dont l’impact est à diminuer au maximum. Le rôle infirmier dans les transmissions est important pour le travail en équipe mais aussi pour le rôle de leader clinique que les infirmier.ère.s se doivent de développer. Lors de ce travail, la recherche sur les bases de données Pubmed et CINAHL a permis de sélectionner 9 articles au préalable dont 7 articles sont retenus pour répondre à la question de recherche. Dans les résultats, l’importance de la cohésion de l’équipe est relevée afin que la dynamique de l’équipe soit productive et dirigée vers le même but : la sécurité du patient. La formation continue permet aux infirmier.ère.s de développer leur pratique et leurs capacités professionnelles. L’implantation des outils mnémotechniques est très présente pour améliorer la qualité des transmissions mais les auteurs des divers articles rappellent l’importance de l’adapter au contexte du service. La normalisation de la transmission permet de diminuer les informations inutiles et de garder une précision pour des transmissions complètes. L’évaluation régulière des pratiques est un point important relevé en conclusion de ce travail.
Symmetric data structure for conjugate computation, distance, and sensitivity analysis of convexity for bivariate convex piecewise linear quadratic functions
Creators: name: Kagdiwala, Zenab Kutubuddin
Publisher: name: University of British Columbia
Year: 2022

description: The objective of this thesis is to develop efficient algorithms and data structures appropriate to support future dynamic algorithms for the conjugate operator in the Computational Convex Analysis (CCA) toolbox for piecewise-defined functions. The CCA toolbox implements efficient tools for computing essential transformations that arise in convex analysis. We focus only on piecewise linear-quadratic (PLQ) functions in our research. Different data structures can be used to represent this class of functions. We offer two representations as well as conversion methods between them. Using the symmetric data structure, we implement an offline conjugate method that runs in linear time. Additionally, we compute the distance between two PLQ functions, which is useful for unit testing and managing floating point issues. The input of a dynamic conjugate algorithm will be a convex PLQ function (called primal). The goal is to output the conjugate (dual) object 𝑷﹡each time the input data is modified. As a first step, we perform a sensitivity analysis to compute local modifications that keep the function convex. The primal objects are modified by changing either vertices or function coefficients or both. An interactive visualization using MATLAB's AppDesigner is developed. The graphical user interface (GUI) modifies the primal object 𝑷 using different interaction techniques and displays the modification on visualization of 𝑷﹡.
Diversity Rationales & Judges
Creators: name: Kyneshawau Hurd
name: Plaut, Victoria C.
name: N. Derek Brown
name: Starck, Jordan
name: Jacoby-Senghor, Drew S
Publisher: name: OSF Registries
Year: 2023
Subjects: subject: Social and Behavioral Sciences

description: This project primarily seeks to understand judges’ proclivity to support instrumental vs. moral arguments for universities having the right to have race-conscious admissions policies.
Saúde Única em Periferias: biopolítica, determinação social e campo de práxis
Creators: name: Baquero, Oswaldo Santos
name: Amorim, Júlia
Publisher: name: Zenodo
Year: 2023

description: Tradução ao portugês do artigo: One Health of Peripheries: Biopolitics, Social Determination, and Field of Praxis. https://doi.org/10.3389/fpubh.2021.617003
Portuguese translation of the article: One Health of Peripheries: Biopolitics, Social Determination, and Field of Praxis. https://doi.org/10.3389/fpubh.2021.617003
Se este documento for usado em outros trabalhos, citar o artigo original. Em caso de usar citações da tradução, citar também a tradução.
title: Le rôle infirmier en Etablissement Médico-Social vaudois face à un résident ayant recours au suicide assisté
title: Le rôle infirmier en Etablissement Médico-Social vaudois face à un résident ayant recours au suicide assisté
titleType: AlternativeTitle
Creators: name: Maggi, Margaux
name: Mange, Tatiana
Publisher: name: Unknown
Year: 0
Subjects: subject: Etablissement Médico-Social
subject: Soins infirmiers
subject: Suicide assisté

description: Ce travail est une analyse d’articles scientifiques, complété par l’étude d’articles de presse et l’analyse des entretiens nous permettant de mettre en avant le rôle que joue une infirmière lorsqu’un résident demande à faire recours au suicide assisté en EMS. L’épidémiologie, les aspects légaux ainsi que l’éthique sont également des points abordés dans cette analyse. Il a été réalisé et écrit en se basant sur un grand nombre d’informations venant de l’Association d’assistance au suicide de Suisse romande, EXIT. En premier lieu, nous exposerons notre problématique, la loi, nos motivations quant au choix de ce thème, ainsi que les théories infirmières. Ceci nous sert à répondre le plus précisément à notre problématique et nous permet d’avoir des pistes dans notre pratique professionnelle. L'épidémiologie montre la thématique sous un autre angle ; certains chiffres mettent en lumière la réalité du sujet. Pour constituer au mieux ce point, beaucoup de recherches ont été faites sur le site de l’association d’EXIT. De plus, un contact téléphonique à l’Office Fédéral de la Statistique (OFS) ainsi qu’à l’Association CURAVIVA Suisse nous a aider à réaliser les statistiques aussi précises que possible. Ensuite, notre question PICOT pose clairement notre question de recherche, annonce la population ciblée, les interventions, le contexte, les résultats attendus et enfin la temporalité de nos recherches. Celle-ci fixe le cadre de notre travail afin de cibler et de filtrer nos recherches dans les diverses bases de données. La méthodologie montre notre cheminement pour arriver à nos fins. Nos difficultés, nos réflexions, nos façons de procéder afin d’avoir sept articles scientifiques qui seront nos éléments clés afin de répondre à notre problématique. En regard de notre thématique, nous avons rencontré des difficultés pour trouver des articles pertinents sur les bases de données. Nous avons dû à plusieurs reprises élargir nos termes de recherches pour obtenir des résultats. C’est pourquoi, nous avons également usé de sources extrascientifiques telles que deux entretiens, et des articles de presse venant de brochures et de journaux. Les synthèses ainsi que les principaux résultats de nos articles scientifiques, de presses, de nos entretiens seront présentés dans la partie résultats de notre travail. Nos articles seront exposés dans un tableau comparatif permettant de justifier le choix de nos articles.
Cytochrome P450 monooxygenase-mediated tailoring of triterpenoids and steroids in plants
Creators: name: Malhotra, Karan
name: Franke, Jakob
Publisher: name: Frankfurt, Main : Beilstein-Institut zur Förderung der Chemischen Wissenschaften
Year: 2022
Subjects: subject: biosynthesis
subject: CYPs
subject: cytochrome P450 monooxygenases
subject: plants
subject: steroid
subject: sterol
subject: triterpene
subject: triterpenoid
subject: Dewey Decimal Classification::500 | Naturwissenschaften::540 | Chemie

description: The cytochrome P450 monooxygenase (CYP) superfamily comprises hemethiolate enzymes that perform remarkable regio- and stereospecific oxidative chemistry. As such, CYPs are key agents for the structural and functional tailoring of triterpenoids, one of the largest classes of plant natural products with widespread applications in pharmaceuticals, food, cosmetics, and agricultural industries. In this review, we provide a full overview of 149 functionally characterised CYPs involved in the biosynthesis of triterpenoids and steroids in primary as well as in specialised metabolism. We describe the phylogenetic distribution of triterpenoid- and steroid-modifying CYPs across the plant CYPome, present a structure-based summary of their reactions, and highlight recent examples of particular interest to the field. Our review therefore provides a comprehensive up-to-date picture of CYPs involved in the biosynthesis of triterpenoids and steroids in plants as a starting point for future research.
Supplementary Table 1 for Pascoal et al. from Parental care results in a greater mutation load, for which it is also a phenotypic antidote
Creators: name: Pascoal, Sonia
name: Shimadzu, Hideyasu
name: Mashoodh, Rahia
name: Kilner, Rebecca M.
Publisher: name: The Royal Society
Year: 2023
Subjects: subject: Evolutionary Biology
subject: FOS: Biological sciences
subject: 60801 Animal Behaviour

description: Median survival times of each lineage (measured in generations) in the Evolutionary History Experiment, with lower and upper 95% confidence intervals (CI). See Figure 1 for design of the Evolutionary History Experiment. ‘Breeding Condition’ indicates whether lineages were inbred or outbred. ‘Evolutionary History’ indicates whether lineages were derived from the No Care or Full Care evolving populations. ‘Current Environment’ refers to whether lineages experienced No Care or Full Care in the Evolutionary History Experiment. (NA = populations did not go extinct).
title: Participation à une recherche
title: programme Emotions Positives pour la Schizophrénie (PEPS)
titleType: Subtitle
title: Participation à une recherche
titleType: AlternativeTitle
Creators: name: Medevielle, Candice
name: Jaquet, Fatim-Zohra
Publisher: name: Unknown
Year: 0
Subjects: subject: Projet scientifique
subject: Soins infirmiers
subject: Schizophrénie

description: Dans le cadre de notre Travail de Bachelor incorporé à la recherche 2019-2020 au sein de l’Institut et Haute Ecole de la Santé La Source, nous avons eu la chance d’évoluer dans un groupe composé d’étudiants et d’enseignants collaborant au sein du Laboratoire d’Enseignement et Recherche en Santé Mentale et Psychiatrie (LER SMP) en regard du Programme Emotions Positives pour la Schizophrénie (PEPS). Selon Favrod et al. (2016) « Le programme Émotions positives pour la schizophrénie (PEPS) est un programme groupal qui cherche à réduire l’anhédonie et l’apathie en augmentant le contrôle cognitif des émotions positives » (p.132). Ce dernier étant composé de plusieurs étapes distinctes, nous avons fait le choix de partager aux lecteurs de ce travail les tenants et les aboutissants de chaque séance ; la visée étant d’apporter un regard professionnel, chronologique et détaillé, en tant que participantes ou en tant qu’observatrices. Nous avons choisi de documenter notre cheminement réflexif d’ordres académique et pratique (se référer aux annexes 4 et 5) afin de mettre en lumière l’ensemble des savoirs dont nous avons bénéficié. En outre, nous avons souhaité incorporer les travaux ainsi que les documents que nous devions fournir à nos directeurs de Travail de Bachelor afin de rendre compte de nos progressions, tant personnelles que professionnelles. Dès lors et en regard du travail continu qu’il nous était demandé d’effectuer, nous avons produit divers documents soumis à hétéroévaluation. Plus spécifiquement, il était question de remplir des échelles visant à identifier notre évolution conjointement au programme PEPS. Au terme du travail, les enseignants nous ont présenté les résultats de notre implication au sein de la recherche. Conscientes que notre participation à PEPS ainsi que notre collaboration – en tant que binôme de futures professionnelles – allait avoir un potentiel impact sur la prise en soin de la patientèle bénéficiant de la plateforme EPEPS, il nous tenait d’autant plus à coeur de rendre compte du travail effectué de la manière la plus précise possible. Afin de conclure cet écrit, nous allons vous présenter l’ensemble des apprentissages que nous avons respectivement réalisés au sein de PEPS ainsi que leurs contributions à la formation de nos identités professionnelles respectives en tant qu’infirmières en devenir.
Relocatable modular capacities in risk aware strategic supply network planning under demand uncertainty
Creators: name: Kayser, Ariane
name: Sahling, Florian
Publisher: name: Wiesbaden : Springer Fachmedien
Year: 2022
Subjects: subject: Conditional value at risk
subject: Modular capacities
subject: Stochastic demand
subject: Supply network reconfiguration
subject: Dewey Decimal Classification::600 | Technik::650 | Management

description: We propose a new model formulation for a three-echelon supply network design problem incorporating the concept of relocatable modular capacities. A robust supply network configuration must be determined based on uncertain demand. Furthermore, by incorporating the conditional value at risk (CVaR), the risk induced by uncertain demand is explicitly considered. The derived supply network configuration should maximize the weighted sum of the expected net present value and the CVaR. The resulting nonlinear model formulation is approximated by a piecewise linearization. Our numerical investigation shows that the derived supply network configuration is robust and stable in the presence of uncertain demand.
title: L’impact du suicide assisté sur les professionnels de la santé
title: L’impact du suicide assisté sur les professionnels de la santé
titleType: AlternativeTitle
Creators: name: Noël, Valentine
Publisher: name: Unknown
Year: 0
Subjects: subject: Suicide assisté
subject: Vécu infirmier

description: Depuis 1982, cinq associations proposant l’assistance au suicide ont vu le jour en Suisse. C’est un des rare pays à proposer ce service de plus en plus demandé par les suisses, mais aussi par des personnes ne résidants pas dans le pays. Les personnes atteintes de neuropathologies à hauts risques de comportements suicidaires, entre autre, peuvent, grâce à ces organisations, appréhender leur désir de mourir d’une manière différente. Suite à une forte demande, le nombre d’hôpitaux et d’institutions médico-sociales qui acceptent l’assistance au suicide entre leurs murs est en constante augmentation. Il me semblait donc intéressant de traiter, dans ce travail de Bachelor, un sujet en expansion et relativement propre à l’endroit où je compte exercer mon futur métier d’infirmière.
Study of feasibility for the reintroduction of the mexican wolf (Canis lupus baileyi), in Sierra de Cardos, Zacatecas
Creators: name: Michel-Hernández, Misael A.
Publisher: name: Zenodo
Year: 2019
Subjects: subject: Mexican wolf
subject: Social acceptance
subject: Population density
subject: Canis lupus baileyi
subject: Reintroduction
subject: Conflict resolution
subject: Habitat
subject: Zacatecas
subject: Sierra de Cardos
subject: IMRN
subject: http://agrovoc.uniroma2.it/agrovoc/agrovoc/en/page/c_9576
subject: http://agrovoc.uniroma2.it/agrovoc/agrovoc/en/page/c_8419
subject: http://agrovoc.uniroma2.it/agrovoc/agrovoc/en/page/c_24103
subject: http://agrovoc.uniroma2.it/agrovoc/agrovoc/en/page/c_8389

description: Abstract: The Mexican wolf is probably extinct in the wild and, the attempts that have been made, have not worked because they are still killing them, since they have only worked with the owners of the land, where they are freed, doing little work with the rural communities. That is why the socio-environmental feasibility for the reintroduction of the Mexican wolf (Canis lupus baileyi) was determined in the municipality of Susticacán, Zacatecas, which is located within the Sierra de Cardos. The level of social acceptance was determined through surveys, using descriptive and multiple discriminant analysis. The quality of the habitat was verified through the density of potential prey (food), vegetation cover and water availability. The surveys were applied to 80 inhabitants older than 15 years. The density of prey and domestic animals was estimated by counting fecal groups in transects in a strip, during the dry season of 2018 (March-May). Plant cover was determined using Canfield lines. Water availability was obtained using free access GIS. The social acceptance was positive (55.1%), specifically related to the fact that they would like their grandchildren to see wolves in the wild. In the case of the densities of potential prey, although the white-tailed deer obtained the highest density (<7 ind / km²), a limited number was perceived, since the wolves required twice as many individuals to settle, while the bovine was the domestic herbivore that obtained the highest density (<35 ind / km²), which in case of installing a family group could generate conflicts with humans. Coverage and space are not limiting factors for the reinsertion of the wolf, since its greatest limitation is the availability of food. Water is the resource found throughout the municipality, either by rivers or artificial bodies of water. Considering this, the tools used for this work can help to know if it is feasible or not the reintroduction of the species and that, if it is feasible, it is effective, because it also provides information about what needs to be worked with people previously (improve habitat), provide environmental education or establish strategies for livestock management - conflict resolution).
description: Thesis. M. Sc. in Innovation in Natural Resources Management, Colegio de Postgraduados, Campus San Luis Potosí, 2018
ANALYZING THE CONTEXT OF KURDISH MIGRATION IN HAKKÂRI IN 1915 THROUGH A CONSTRUCTIVIST LENS
Creators: name: Mirza, Hadzic
name: Ayşe, Nur Yılmaz
Publisher: name: AMERICAN SERIAL
Year: 2024
Subjects: First World War
forced migration
ethnic conflicts
Ottoman Empire
Hakkâri

description: The First World War stands as a pivotal moment in history, marked by the collapse of three major empires and the emergence of new states. Alongside the staggering human toll of the war, forced migrations catalyzed by the conflict resulted in profound human tragedies. Prior to the war, individuals of diverse ethnic and religious backgrounds coexisted under the Ottoman Empire's rule. However, the imperial policies of various states during the war led to tensions between non-Muslim subjects and Muslims. These tensions culminated in conflicts that forced both Muslims and non-Muslims to flee their homes. In the region of Hakkâri, clashes between Nestorians and Kurds prompted the mass emigration of both groups. Kurds, an ancient people of Hakkâri, had previously cohabited with the Nestorians/Assyrians in the Hakkâri mountains until 1915
High-pressure macromolecular crystallography at Aichi-SR
Creators: name: Chavas, Leonard
Publisher: name: Zenodo
Year: 2021

description: The Aichi synchrotron is a 1.2 GeV synchrotron located in Nagoya suburbs. The small electron storage ring provides synchrotron light to X beamlines, operating at 300 mA on a top-up injection mode. The beamline BL2S1 is accommodated in one of the available bending magnets of Aichi synchrotron. The end-station was built and is maintained by the Nagoya University Synchrotron Radiation Research Center since 2015. By adjusting a series of dedicated optics, the beamline can accommodate various types of experiments, including single-crystal diffraction, powder diffraction, and high-pressure diffraction. High-pressure protein x-ray crystallography (hereafter referred to HPPX) is a specific branch of macromolecular crystallography that provides mixed information of protein structures placed under various pressure conditions. Hence, the HPPX technique gives valuable insights in the hydration states at the molecular surface of the proteins, and within internal cavities. Moreover, the method can be applied for investigating the different states of biological events (e.g. enzymatic reaction mechanisms...) or for the study of the differences among deep sea and homolog ‘ambient pressure’ organisms. In the current presentation, I will summarize the HPPX results obtained at the BL2S1 beamline during its 6 years of operation. Some emphasizes will be given on the future implementation plans of the beamline, both in terms of HPPX and for more classical experimental setups.
AdaCC: cumulative cost-sensitive boosting for imbalanced classification
Creators: name: Iosifidis, Vasileios
name: Papadopoulos, Symeon
name: Rosenhahn, Bodo
name: Ntoutsi, Eirini
Publisher: name: London : Springer
Year: 2022
Subjects: subject: Boosting
subject: Class imbalance
subject: Cost-sensitive learning
subject: Cumulative costs
subject: Dynamic costs
subject: Dewey Decimal Classification::000 | Allgemeines, Wissenschaft::000 | Informatik, Wissen, Systeme::004 | Informatik
subject: Dewey Decimal Classification::000 | Allgemeines, Wissenschaft::070 | Nachrichtenmedien, Journalismus, Verlagswesen

description: Class imbalance poses a major challenge for machine learning as most supervised learning models might exhibit bias towards the majority class and under-perform in the minority class. Cost-sensitive learning tackles this problem by treating the classes differently, formulated typically via a user-defined fixed misclassification cost matrix provided as input to the learner. Such parameter tuning is a challenging task that requires domain knowledge and moreover, wrong adjustments might lead to overall predictive performance deterioration. In this work, we propose a novel cost-sensitive boosting approach for imbalanced data that dynamically adjusts the misclassification costs over the boosting rounds in response to model’s performance instead of using a fixed misclassification cost matrix. Our method, called AdaCC, is parameter-free as it relies on the cumulative behavior of the boosting model in order to adjust the misclassification costs for the next boosting round and comes with theoretical guarantees regarding the training error. Experiments on 27 real-world datasets from different domains with high class imbalance demonstrate the superiority of our method over 12 state-of-the-art cost-sensitive boosting approaches exhibiting consistent improvements in different measures, for instance, in the range of [0.3–28.56%] for AUC, [3.4–21.4%] for balanced accuracy, [4.8–45%] for gmean and [7.4–85.5%] for recall.
Influence of honeycomb structures on straight-through labyrinth seal aerodynamics
Creators: name: Oettinger, Marcel
name: Kluge, Tim
name: Seume, Joerg
Publisher: name: [Zug] : GPPS
Year: 2022
Subjects: subject: aerodynamics
subject: cavity
subject: honeycomb
subject: labyrinth seal
subject: performance
subject: turbine
subject: Dewey Decimal Classification::600 | Technik::620 | Ingenieurwissenschaften und Maschinenbau

description: Shroud cavities in aero engines are typically formed by a labyrinth seal between the rotating turbine shroud and the stationary casing wall. To mitigate rub-in and reduce weight, the casing often features honeycomb structures above the rotor seal fins. In this paper, the aerodynamic performance of such honeycomb structures is experimentally investigated using a rotating test rig featuring both smooth and honeycomb-tapered casing walls. Measurements show that the discharge coefficient decreases for the honeycomb configuration while losses and subsequent windage heating of the flow increase. A variation in rotational speed reveals additional sensitivities to the local flow field in the swirl chamber. Numerical simulations are conducted and validated using the experiments. A good agreement between the prediction and measurements of the jet via the evolution of pressure across the sealing fins is identified. In contrast, the prediction of losses and integral parameters reveals larger deficits. Empirical correlations from available literature satisfactorily predict the leakage mass flow rate if rotation is low and if the casing is smooth. High rotation and the presence of honeycombs, however, prove challenging and reveal the potential for further improvements. We propose a simple a-posteriori correction that can capture the effect of honeycomb structures on seal discharge by accounting for changes in momentum and flow area.
An examination of people’s preferences for buildings and streetscapes in New Zealand
Creators: name: Gjerde, Morten
name: Vale, Brenda
Publisher: name: Open Access Victoria University of Wellington | Te Herenga Waka
Year: 2022
Subjects: subject: 120599 Urban and Regional Planning not elsewhere classified
subject: FOS: Social and economic geography
subject: 50299 Environmental Science and Management not elsewhere classified
subject: FOS: Earth and related environmental sciences

description: No description supplied
Identification of curcuminoids in nutraceuticals and assessment of stability and bioactivity following pulsed light treatment
Creators: name: Zhang, Huiying
Publisher: name: University of British Columbia
Year: 2024

description: Curcuminoids are the major group of bioactive polyphenolic compounds isolated from turmeric (rhizome of Curcuma longa) that has been attributed to several bioactivities and health benefits. Within this group, curcumin (CUR) is the principal component that accounts for 77%; other major components are demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC) that account for 17% and 3%, respectively. Some factors limiting the pharmaceutical and nutraceutical applications of curcuminoids include relatively poor water solubility, bioavailability and chemical stability. This thesis aims to compare the chemical- and cell-based antioxidant capacity of a random selection of commercial curcuminoid-based nutraceutical products with pure CUR, DMC, and BDMC standards (Chapter 2); emphasis was given to investigate the photochemical stability of CUR upon pulsed light (PL) treatment, an emerging light-based food processing technology, and to determine if the antioxidant capacity of curcumin would be affected (Chapter 3). Chemical-based antioxidant capacity was assessed by 2,2’-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid radical cation (ABTS•+) and oxygen radical absorbance capacity (ORAC) assay, and cell-based antioxidant capacity was assessed by 2’,7’-dichloro-dihydro-fluorescein diacetate (DCFH-DA) and glutathione assays using a differentiated Caco-2 cell model. In Chapter 2, it was found that the chemical-based antioxidant capacity of curcuminoid supplements was positively correlated with total curcuminoid content and each of the individual curcuminoid content, and CUR showed the strongest correlation among the three major curcuminoids. The cellular antioxidant capacity in differentiated Caco-2 cells was more dependent on the formulation techniques used to manufacture the supplements. In Chapter 3, a positive correlation was found between losses of CUR content with the fluence of PL treatment within the tested range (0.14 – 12.75 J/cm²). However, fluence level and losses of CUR did not directly relate to losses in antioxidant capacity. When compared to the untreated control, PL-treated CUR at relatively high fluence levels showed a decreased chemical-based antioxidant capacity but an increased capacity to alleviate oxidative stress in differentiated Caco-2 cells. Tentative curcumin dimers were identified as potential photochemical transformation products of CUR by PL treatment. In conclusion, the application of PL on CUR can induce photochemical transformation of the compound, such as dimerization, and this may potentially enhance the biological antioxidant capacity.