cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Analyse et synthèse des expérimentations et actions de restauration écologique réalisées sur sites miniers en Nouvelle-Calédonie depuis 30 ans. Rapport scientifique final
Creators: name: Amir, Hamid
name: Fogliani, Bruno
name: Gensous, Simon
name: Durrieu, Gilles
name: L'Huillier, Laurent
name: Saintpierre, Danielle
name: Reck, Adeline
name: Lagrange, Alexandre
name: Gaillard, Thomas
Publisher: name: CNRT Nickel et son environnement
Year: 2018
Subjects: subject: FOS: Earth and related environmental sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Programme Recosynth. (Tome Nickel et Environnement)
Lattice of infinite bending-resistant fibers
Creators: name: Kobelev, V.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: This article present the double-periodical lattice made of infinite elastic fibers that withstand bending and tension. The model describes the elastic properties of flat periodic structure. With this model the behavior of a two-dimensional array of infinite fibers is simulated. The material that contains a row of broken fibers is considered. These broken fibers form the failure in the material that shapes like a long straight crack. The lattice is tensioned in the direction, which is orthogonal to the direction of straight crack. The conditions of fracture of this lattice are investigated. The closed form expression for the stress in the first unbroken fiber and the expression for fracture toughness are given. These values are the functions of mechanical parameters of lattice and tensions in both families of fibers. The closed form solution demonstrates a notable behavior of the material. Namely, the fracture behavior of two-dimensional lattice is cardinally depends upon the pre-stress in the material in the direction, parallel to crack direction. If the tension in fibers that parallel to the crack direction exists, it stabilizes the crack growth and makes the load distribution in the unbroken fibers more even. The two-dimensional lattice behaves in the presence of tension in both directions similarly to the plane elastic media. The finite length crack assumes the shape of the elongated elliptic split. Another behavior of lattice occurs if the fibers, parallel to crack direction, are unstressed. The character of stress concentration near the crack differs. The load distribution at the crack tip varies considerably. The first unbroken fiber carries higher load. The crack is lens-shaped and the crack borders form at the tip the finite angle.
Hungaria region as possible source of Trojans and satellites in the inner solar-system
Creators: name: Galiazzo, Mattia Alvise
name: Schwarz, Richard
Publisher: name: arXiv
Year: 2016
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: The Hungaria Family (the closest region of the Main Belt to Mars) is an important source of Planet-Crossing-Asteroids and even impactors of terrestrial planets. We present the possibility that asteroids coming from the Hungaria Family get captured into co-orbital motion with the terrestrial planets in the inner solar system. Therefore we carried out long term numerical integrations (up to 100 Myr) to analyze the migrations from their original location - the Hungaria family region- into the inner solar system. During the integration time we observed whether or not the Hungarias get captured into a co-orbital motion with the terrestrial planets. Our results show that 5.5% of 200 Hungarias, selected as a sample of the whole group, escape from the Hungaria region and the probability from that to become co-orbital objects (Trojans, satellites or horseshoes) turns out to be about 3.3%: 1.8% for Mars and 1.5% for the Earth. In addition, we distinguished in which classes of co-orbital motion the asteroids get captured and for how long they stay there in stable motion. Most of the escaped Hungarias become Quasi-satellites and the ones captured as Trojans favor the L_5 lagrangian point. This work highlights that the Hungaria region is a source of Mars and also Earth co-orbital objects.
Molecularly engineering a dual-drug nanoassembly for self-sensitized photodynamic therapy via thioredoxin impairment and glutathione depletion
Creators: name: Zhang, Hongyuan
name: Kong, Zhiqiang
name: Wang, Ziyue
name: Chen, Yao
name: Zhang, Shenwu
name: Luo, Cong
Publisher: name: Taylor & Francis
Year: 2022
Subjects: Biochemistry
Space Science
Medicine
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
Computational Biology

description: Photodynamic therapy (PDT) has been extensively investigated as a spatiotemporally noninvasive and controllable modality for cancer treatment. However, the intracellular antioxidant systems mainly consisting of thioredoxin (Trx) and glutathione (GSH) significantly counteract and prevent reactive oxygen species (ROS) accumulation, resulting in a serious loss of PDT efficiency. To address this challenge, we propose that PDT can be improved by precisely blocking antioxidant systems. After molecular engineering and synergistic cytotoxic optimization, a DSPE-PEG2K-modified dual-drug nanoassembly (PPa@GA/DSPE-PEG2K NPs) of pyropheophorbide a (PPa) and gambogic acid (GA) is successfully constructed. Interestingly, GA can effectively destroy intracellular antioxidant systems by simultaneously inhibiting Trx and GSH. Under laser irradiation, the cell-killing effects of PPa is significantly enhanced by GA-induced inhibition of the antioxidant systems. As expected, PPa@GA/DSPE-PEG2K nanoparticles demonstrate potent antitumor activity in a 4T1 breast tumor-bearing BALB/c mouse xenograft model. Such a carrier-free self-sensitized nanotherapeutic offers a novel co-delivery strategy for effective PDT.
Risk of overhydration and low lean tissue index as measured using a body composition monitor in patients on hemodialysis: a systemic review and meta-analysis
Creators: name: Hwang, Seun Deuk
name: Lee, Jin Ho
name: Lee, Seoung Woo
name: Kim, Joong Kyung
name: Moon-Jae Kim
name: Song, Joon Ho
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Medicine
subject: Physiology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: 69999 Biological Sciences not elsewhere classified
subject: Science Policy

description: Overhydration and sarcopenia, related to an individual’s nutritional status, have been associated with increased cardiovascular mortality and poor prognosis in patients on hemodialysis. The purpose of this study was to investigate the prediction of overhydration and sarcopenia on mortality in patients on hemodialysis using a body composition monitor. We conducted a systematic review and meta-analysis using a random-effects model. We searched the Cochrane Central Register, OVID MEDLINE, EMBASE and PubMed databases for all studies published prior to December 9, 2016 and reviewed the reference lists of relevant reviews, registered trials and relevant conference proceedings. The overhydration group (fluid excess, >15% vs. the normohydration group) and the low lean tissue index group ( <10%) were compared with a reference group. Six trials, consisting of 29,469 patients, were included in the pooled analysis. The pooled hazard ratio for overall survival of the overhydration group, compared with the reference normohydration group was 1.798 (95% confidence interval [CI]: 1.53–2.804, p = .001). The hazard ratio for mortality in the low lean tissue index group was 1.533 (95% CI, 1.411–1.644; p = .001) in the random-effects model. The results from the most recent study showed the greatest heterogeneity in the sensitivity analysis. Low lean tissue index and overhydration, measured using a body composition monitor, were associated with a high mortality rate in patients on hemodialysis.
Herschel survey and modelling of externally-illuminated photoevaporating protoplanetary disks
Creators: name: Champion, Jason
name: Berné, Olivier
name: Vicente, Silvia
name: Kamp, Inga
name: Petit, Franck Le
name: Gusdorf, Antoine
name: Joblin, Christine
name: Goicoechea, Javier R.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: FOS: Physical sciences

description: Protoplanetary disks undergo substantial mass-loss by photoevaporation, a mechanism which is crucial to their dynamical evolution. However, the processes regulating the gas energetics have not been well constrained by observations so far. We aim at studying the processes involved in disk photoevaporation when it is driven by far-UV photons. We present a unique Herschel survey and new ALMA observations of four externally-illuminated photoevaporating disks (a.k.a. proplyds). For the analysis of these data, we developed a 1D model of the photodissociation region (PDR) of a proplyd, based on the Meudon PDR code and computed the far infrared line emission. We successfully reproduce most of the observations and derive key physical parameters, i.e. densities at the disk surface of about $10^{6}$ cm$^{-3}$ and local gas temperatures of about 1000 K. Our modelling suggests that all studied disks are found in a transitional regime resulting from the interplay between several heating and cooling processes that we identify. These differ from those dominating in classical PDRs, i.e. grain photo-electric effect and cooling by [OI] and [CII] FIR lines. This energetic regime is associated to an equilibrium dynamical point of the photoevaporation flow: the mass-loss rate is self-regulated to set the envelope column density at a value that maintains the temperature at the disk surface around 1000 K. From our best-fit models, we estimate mass-loss rates - of the order of $10^{-7}$ $\mathrm{M}_\odot$/yr - that are in agreement with earlier spectroscopic observation of ionised gas tracers. This holds only if we assume an evaporation flow launched from the disk surface at sound speed (supercritical regime). We have identified the energetic regime regulating FUV-photoevaporation in proplyds. This regime could be implemented into models of the dynamical evolution of protoplanetary disks.
description: 17 pages (6 more with appendices), 11 figures, accepted for publication in A&A
Optimization of process parameters for fabrication of electrospun nanofibers containing neomycin sulfate and Malva sylvestris extract for a better diabetic wound healing
Creators: name: Islam, Mohammed Monirul
name: Ramesh, Varshini Hemmanahalli
name: Bhavani, Penmetsa Durga
name: Goudanavar, Prakash S.
name: Naveen, N. Raghavendra
name: Ramesh, B.
name: Fattepur, Santosh
name: Shiroorkar, Predeepkumar Narayanappa
name: Habeebuddin, Mohammed
name: Meravanige, Girish
name: Telsang, Mallikarjun
name: Sreeharsha, Nagaraja
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Biochemistry
subject: Chemical Sciences not elsewhere classified
subject: Immunology
subject: FOS: Clinical medicine
subject: Cancer
subject: Infectious Diseases
subject: FOS: Health sciences

description: Diabetes mellitus is one of the most concerning conditions, and its chronic consequences are almost always accompanied by infection, oxidative stress, and inflammation. Reducing excessive reactive oxygen species and the wound’s inflammatory response is a necessary treatment during the acute inflammatory phase of diabetic wound healing. Malva sylvestris extract (MS) containing nanofibers containing neomycin sulfate (NS) were synthesized for this investigation, and their impact on the healing process of diabetic wounds was assessed. Using Design Expert, the electrospinning process for the fabrication of NS nanofibers (NS-NF) was adjusted for applied voltage (X1), the distance between the needle’s tip and the collector (X2), and the feed rate (X3) for attaining desired entrapment efficacy [EE] and average nanofiber diameter (ND). The optimal formulation can be prepared with 19.11 kV of voltage, 20 cm of distance, and a flow rate of 0.502 mL/h utilizing the desirability approach. All the selected parameters and responses have their impact on drug delivery from nanofibers. In addition, M. sylvestris extracts have been added into the optimal formulation [MS-NS-NF] and assessed for their surface morphology, tensile strength, water absorption potential, and in vitro drug release studies. The NS and MS delivery from MS-NS-NF has been extended for more than 60 h. M. sylvestris-loaded nanofibers demonstrated superior antibacterial activity compared to plain NS nanofibers. The scaffolds featured a broad aspect and a highly linked porous fibrous network structure. Histomorphometry study and the in vitro scratch assay demonstrate the formulation’s efficacy in treating diabetic wound healing. The cells treated with MS-NS-NF in vivo demonstrated that wound dressings successfully reduced both acute and chronic inflammations. To improve the healing of diabetic wounds, MS-NS-NF may be regarded as an appropriate candidate for wound dressing.
title: Atlas des DOM. - La Réunion - Planche 36 : Scolarité : notices, page 2, 3, 4
Creators: name: Perrolat, Gérard
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2017
Subjects: subject: établissement d'enseignement
subject: enseignement
subject: enseignement agricole
subject: enseignement général
subject: enseignement primaire
subject: enseignement secondaire
subject: enseignement supérieur
subject: formation professionnelle
subject: politique de l'éducation
subject: scolarisation
subject: éducation
subject: élève
subject: économie de l'éducation
subject: enseignement technique
subject: école

description: La page 2 présente les effectifs scolaires d'un point de vue quantitatif. Deux graphiques et deux tableaux appuient ces propos : un graphique en courbes montre l'évolution du flux de rentrée et du flux de sortie dans l'enseignement du 1er degré public (y compris l'enseignement pré-scolaire) de 1966 à 1971, un graphique en courbes montre l'évolution des effectifs scolaires de 1950 à 1970, un tableau montre la répartition des effectifs scolaires dans les différents établissements d'enseignement de 1970 à 1971, un tableau montre la scolarisation dans l'enseignement des 1er et 2e degrés par année de naissance et par niveau d'enseignement. La page 3 présente l'enseignement pré-scolaire et l'enseignement primaire puis les problèmes propres à l'enseignement du premier degré. Présente le premier cycle du second degré. Deux graphiques et deux tableaux appuient ces propos : un tableau donne la répartition des écoles primaires en fonction du nombre de classes et d'élèves, un graphique en courbes montre la répartition des filles et des garçons scolarisés en 1970, un tableau donne le nombre de classes financées de 1963 à 1970, un graphique en courbes montre l'évolution du nombre de rationnaires des cantines scolaires dans l'enseignement public et privé du premier degré de 1963 à 1970. Page 4 : suite de la présentation du premier cycle du second degré, puis présentation du second cycle. Présente l'enseignement technique, puis les enseignements des 1er et 2e degré et du technique ainsi que l'enseignement supérieur et les établissements particuliers. Trois graphiques et deux tableaux appuient ces propos : un graphique en courbes montre l'évolution des inscrits et des admis au Baccalauréat de 1958 à 1970, un tableau donne les effectifs du second cycle technique court de 1964 à 1972, un graphique en courbes montre l'évolution des bourses d'étude de 1965 à 1971, un tableau donne la répartition des enseignants des premier et second degrés et du technique, un graphique en courbes montre l'évolution des effectifs dans l'enseignement supérieur de 1963 à 1971.
description: Relation: http://www.nakala.fr/data/11280/7b38141a
description: Coverage: La Réunion
description: Temporal: start=1950; end=1971;
title: Identification d’indicateurs biologiques du fonctionnement des écosystèmes miniers restaurés. Acronyme : « Bioindic ». Rapport scientifique final
Creators: name: Carriconde, Fabian
name: Nunez, Nicolas Fernandez
name: Ripoll, Julie
name: Léopold, Audrey
name: Fogliani, Bruno
name: Ititiaty, Yawiya
name: Lelievre, Mélanie
name: Letellier, Kelly
name: Maggia, Laurent
name: Bidau, Géraldine
name: L'Huillier, Laurent
name: Amir, Hamid
name: Cavaloc, Yvon
name: Ducousso, Marc
name: Galiana, Antoine
name: Hannibal, Laure
name: Jourand, Philippe
name: Lebrun, Michel
Publisher: name: CNRT Nickel et son environnement
Year: 2019
Subjects: subject: FOS: Earth and related environmental sciences
valueUri: http://www.oecd.org/science/inno/38235147.pdf

description: Programme Bioindic. (Tome Nickel et Environnement)
Targeted co-delivery biomimetic nanoparticles reverse macrophage polarization for enhanced rheumatoid arthritis therapy
Creators: name: Zheng, Xiu
name: Yu, Xin
name: Wang, Chenglong
name: Liu, Yan
name: Jia, Ming
name: Lei, Fenting
name: Tian, Ji
name: Li, Chunhong
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: FOS: Biological sciences
subject: Immunology
subject: FOS: Clinical medicine
subject: Biological Sciences not elsewhere classified

description: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease, which is characterized by synovial inflammation and autoimmunity. The main cause of the disease is the imbalance of the proportion of pro-inflammatory macrophages (M1-type) and anti-inflammatory macrophages (M2-type) in the synovial tissues of the joint. To restore this balance, in our study, the interleukin-10 encoding anti-inflammatory cytokines (IL-10 pDNA) and chemotherapeutic drug dexamethasone sodium phosphate (DSP) were co-loaded into human serum albumin (HSA) preparing pDNA/DSP-NPs to actively target macrophages in synovium tissue to promote M1-M2 polarization. Confocal laser scanning microscope and western blot were used to demonstrate the targeting ability of co-delivery nanoparticles. In vivo, the real-time fluorescence imaging system and HPLC were used to study the tissue distribution and pharmacokinetics of nanoparticles, and the results showed that the accumulation of nanoparticles in the inflammatory joint site was higher. Its pharmacodynamics were evaluated in collagen-induced arthritis (CIA) rat model, and it demonstrated that the pDNA/DSP-NPs significantly reduced the expression of serum inflammatory factors and alleviated joint swelling and bone erosion, suggesting the favorable therapeutic effect. The synergistic treatment effect of IL-10 pDNA and DSP in this system was achieved by reducing the secretion of pro-inflammatory factors (TNF-α, IL-1β) and increasing the expression of anti-inflammatory factors (IL-10) to promote the M1-M2 polarization of macrophages. Our strategy is promising for co-delivery of gene drugs and chemical drugs by biomimetic natural materials to promote macrophages polarization so that to achieve synergically treatment of inflammatory disease.
ONTOPRIMA: A PROTOTYPE FOR AUTOMATING ONTOLOGY POPULATION
Creators: name: Pola, Jackson
Publisher: name: figshare
Year: 2018
Subjects: subject: Biotechnology
subject: 111302 Optical Technology
subject: FOS: Clinical medicine
subject: 91012 Textile Technology
subject: FOS: Materials engineering

description: Ontology Population supports the process of building ontologies in the complex task of instantiating ontology. Performing this process manually is both expensive and time consuming; this logically leads to attempts of fully or partially automating the process of acquisition and absorption of knowledge in general and the process of Ontology Population in particular. This paper presents OntoPRiMa (Ontology Population for PRIMA Project), a prototype based on a semiautomatic approach for ontology population in the domain of risk management. OntoPRiMa demonstrates the feasibility of the proposed approach in populating generic and small domain ontologies from textual corpus with many potentials and possible instances that are unknown and not realized. The prototype is based on Natural Language Processing (NLP) techniques for language processing, semantic web techniques (RDFS, RDF, Jena APIs) for knowledge modeling and representation and on domain expert’s intervention for validating extracted instances. Furthermore, this paper presents an experiment for populating the ontology of the PRIMA project using a text corpus which is consist of chemical fact sheets issued by the U.S. Environmental Protection Agency. We have achieved high precision (above 80%) of knowledge acquisition in this experiment.
Effect of strong magnetic fields on the crust-core transition and inner crust of neutron stars
Creators: name: Fang, Jianjun
name: Pais, Helena
name: Pratapsi, Sagar
name: Avancini, Sidney
name: Li, Jing
name: Providência, Constança
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: The Vlasov equation is used to determine the dispersion relation for the eigenmodes of magnetized nuclear and neutral stellar matter, taking into account the anomalous magnetic moment of nucleons. The formalism is applied to the determination of the dynamical spinodal section, a quantity that gives a good estimation of the crust-core transition in neutron stars. We study the effect of strong magnetic fields, of the order of $10^{15}-10^{17}$ G, on the extension of the crust of magnetized neutron stars. The dynamical instability region of neutron-proton-electron ($npe$) matter at subsaturation densities is determined within a relativistic mean field model. It is shown that a strong magnetic field has a large effect on the instability region, defining the crust-core transition as a succession of stable and unstable regions due to the opening of new Landau levels. The effect of the anomalous magnetic moment is non-negligible for fields larger than 10$^{15}$ G. The complexity of the crust at the transition to the core and the increase of the crust thickness may have direct impact on the properties of neutrons stars related with the crust.
description: 15 pages, 6 figures, accepted for publication in Phys. Rev. C
The Effect of Solutes on the Temperature of Miscibility Transitions in Multi-component Membranes
Creators: name: Allender, D. W.
name: Schick, M.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Statistical Mechanics (cond-mat.stat-mech)
subject: FOS: Physical sciences

description: We address questions posed by experiments which show that most small-chain alcohols reduce the miscibility transition temperature when added to giant plasma membrane vesicles, but increase that temperature when added to giant unilamellar vesicles. In both systems the change in temperature depends non-monotonically on the length of the alcohol chain. To emphasize the roles played by the internal entropies of the components, we model them as linear polymers. We show that, within Flory-Huggins theory, the addition of alcohol causes an increase or decrease of the transition temperature depending upon the competition of two effects. One is the dilution of the solvent interactions caused by the introduction of solute, which tends to lower the temperature. The other is the preference of the solute for one phase or the other, which tends to raise the temperature. The magnitude of this term depends on the entropies of all components. Lastly we provide a reasonable explanation for the behavior of the transition temperature with alcohol chain length observed in experiment.
Using Coalgebras and the Giry Monad for Interpreting Game Logics --- A Tutorial
Creators: name: Doberkat, Ernst-Erich
Publisher: name: arXiv
Year: 2017
Subjects: subject: Logic in Computer Science (cs.LO)
subject: FOS: Computer and information sciences
subject: F.4.1, I.2.3, I.2.4, G.3
subject: 03B45, 18C15, 18C20

description: The stochastic interpretation of Parikh's game logic should not follow the usual pattern of Kripke models, which in turn are based on the Kleisli morphisms for the Giry monad, rather, a specific and more general approach to probabilistic nondeterminism is required. We outline this approach together with its probabilistic and measure theoretic basis, introducing in a leisurely pace the Giry monad and their Kleisli morphisms together with important techniques for manipulating them. Proof establishing specific techniques are given, and pointers to the extant literature are provided. After working through this tutorial, the reader should find it easier to follow the original literature in this and related areas, and it should be possible for her or him to appreciate measure theoretic arguments for original work in the areas of Markov transition systems, and stochastic effectivity functions.
Fine Tuning of Optical Transition Energy of Twisted Bilayer Graphene via Interlayer Distance Modulation
Creators: name: del Corro, Elena
name: Peña-Alvarez, Miriam
name: Sato, Kentaro
name: Morales-Garcia, Angel
name: Bousa, Milan
name: Mračko, Michal
name: Kolman, Radek
name: Pacakova, Barbara
name: Kavan, Ladislav
name: Kalbac, Martin
name: Frank, Otakar
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: Twisted bilayer graphene (tBLG) represents a family of unique materials with optoelectronic properties tuned by the rotation angle between the two layers. The presented work shows an additional way of tweaking the electronic structure of tBLG: by modifying the interlayer distance, for example by a small uniaxial out-of-plane compression. We have focused on the optical transition energy, which shows a clear dependence on the interlayer distance, both experimentally and theoretically.
description: accepted to Physical Review B https://journals.aps.org/prb/accepted/dd078Y90H2517b63a1632e870189c8db652549060
COVAX_Equity_BulletinWHO_Supplement.docx
Creators: name: Yoo, Katelyn Jison
name: Mehta, Akriti
name: Mak, Joshua
name: Bishai, David
name: Chansa, Collins
name: Patenaude, Bryan
Publisher: name: figshare
Year: 2022
Subjects: subject: 140208 Health Economics
subject: FOS: Economics and business
subject: 150309 Logistics and Supply Chain Management

description: Supplementary materials to the research article "COVAX and equitable access to COVID-19 vaccines", published by the Bulletin of the World Health Organization in year 2022.
Biodegradable gemcitabine-loaded microdevice with sustained local drug delivery and improved tumor recurrence inhibition abilities for postoperative pancreatic tumor treatment
Creators: name: Kong, Xiangming
name: Feng, Miao
name: Wu, Lihuang
name: He, Yiyan
name: Mao, Hongli
name: Gu, Zhongwei
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Space Science
subject: Medicine
subject: Genetics
subject: FOS: Biological sciences
subject: Pharmacology
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Cancer

description: At present, the 10-year survival rate of patients with pancreatic cancer is still less than 4%, mainly due to the high cancer recurrence rate caused by incomplete surgery and lack of effective postoperative adjuvant treatment. Systemic chemotherapy remains the only choice for patients after surgery; however, it is accompanied by off-target effects and server systemic toxicity. Herein, we proposed a biodegradable microdevice for local sustained drug delivery and postoperative pancreatic cancer treatment as an alternative and safe option. Biodegradable poly(l-lactic-co-glycolic acid) (P(L)LGA) was developed as the matrix material, gemcitabine hydrochloride (GEM·HCl) was chosen as the therapeutic drug and polyethylene glycol (PEG) was employed as the drug release-controlled regulator. Through adjusting the amount and molecular weight of PEG, the controllable degradation of matrix and the sustained release of GEM·HCl were obtained, thus overcoming the unstable drug release properties of traditional microdevices. The drug release mechanism of microdevice and the regulating action of PEG were studied in detail. More importantly, in the treatment of the postoperative recurrence model of subcutaneous pancreatic tumor in mice, the microdevice showed effective inhibition of postoperative in situ recurrences of pancreatic tumors with excellent biosafety and minimum systemic toxicity. The microdevice developed in this study provides an option for postoperative adjuvant pancreatic treatment, and greatly broadens the application prospects of traditional chemotherapy drugs.
Simulating the interaction between a falling super-quadric object and a soap film
Creators: name: Davies, I. T.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: Fluid Dynamics (physics.flu-dyn)
subject: FOS: Physical sciences

description: The interaction that occurs between a light solid object and a horizontal soap film of a bamboo foam contained in a cylindrical tube is simulated in 3D. We vary the shape of the falling object from a sphere to a cube by changing a single shape parameter as well as varying the initial orientation and position of the object. We investigate in detail how the soap film deforms in all these cases, and determine the network and pressure forces that a foam exerts on a falling object, due to surface tension and bubble pressure respectively. We show that a cubic particle in a particular orientation experiences the largest drag force, and that this orientation is also the most likely outcome of dropping a cube from an arbitrary orientation through a bamboo foam.
COVAX_Equity_BulletinWHO.docx
Creators: name: Yoo, Katelyn Jison
name: Mehta, Akriti
name: Mak, Joshua
name: Bishai, David
name: Chansa, Collins
name: Patenaude, Bryan
Publisher: name: figshare
Year: 2022
Subjects: subject: 140208 Health Economics
subject: FOS: Economics and business
subject: 150309 Logistics and Supply Chain Management

description: Supplementary materials to the research article "COVAX and equitable access to COVID-19 vaccines", published by the Bulletin of the World Health Organization in year 2022.
Biofilm community structure and the associated drag penalties of a groomed fouling release ship hull coating
Creators: name: Hunsucker, Kelli Z.
name: Vora, Gary J.
name: J. Travis Hunsucker
name: Gardner, Harrison
name: Leary, Dagmar H.
name: Seongwon Kim
name: Baochuan Lin
name: Swain, Geoffrey
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Grooming is a proactive method to keep a ship’s hull free of fouling. This approach uses a frequent and gentle wiping of the hull surface to prevent the recruitment of fouling organisms. A study was designed to compare the community composition and the drag associated with biofilms formed on a groomed and ungroomed fouling release coating. The groomed biofilms were dominated by members of the Gammaproteobacteria and Alphaproteobacteria as well the diatoms Navicula, Gomphonemopsis, Cocconeis, and Amphora. Ungroomed biofilms were characterized by Phyllobacteriaceae, Xenococcaceae, Rhodobacteraceae, and the pennate diatoms Cyclophora, Cocconeis, and Amphora. The drag forces associated with a groomed biofilm (0.75 ± 0.09 N) were significantly less than the ungroomed biofilm (1.09 ± 0.06 N). Knowledge gained from this study has helped the design of additional testing which will improve grooming tool design, minimizing the growth of biofilms and thus lowering the frictional drag forces associated with groomed surfaces.
Biofilm community structure and the associated drag penalties of a groomed fouling release ship hull coating
Creators: name: Hunsucker, Kelli Z.
name: Vora, Gary J.
name: J. Travis Hunsucker
name: Gardner, Harrison
name: Leary, Dagmar H.
name: Seongwon Kim
name: Baochuan Lin
name: Swain, Geoffrey
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Space Science
subject: Microbiology
subject: FOS: Biological sciences
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: Ecology
subject: 69999 Biological Sciences not elsewhere classified
subject: 110309 Infectious Diseases
subject: FOS: Health sciences

description: Grooming is a proactive method to keep a ship’s hull free of fouling. This approach uses a frequent and gentle wiping of the hull surface to prevent the recruitment of fouling organisms. A study was designed to compare the community composition and the drag associated with biofilms formed on a groomed and ungroomed fouling release coating. The groomed biofilms were dominated by members of the Gammaproteobacteria and Alphaproteobacteria as well the diatoms Navicula, Gomphonemopsis, Cocconeis, and Amphora. Ungroomed biofilms were characterized by Phyllobacteriaceae, Xenococcaceae, Rhodobacteraceae, and the pennate diatoms Cyclophora, Cocconeis, and Amphora. The drag forces associated with a groomed biofilm (0.75 ± 0.09 N) were significantly less than the ungroomed biofilm (1.09 ± 0.06 N). Knowledge gained from this study has helped the design of additional testing which will improve grooming tool design, minimizing the growth of biofilms and thus lowering the frictional drag forces associated with groomed surfaces.
title: Mail à Maria Sanminiatelli, copie à Christine Bergstrom, transféré à John David - Pièce jointe
Creators: name: Leibowitch, Jacques
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Pièce jointe : "A NEW EDGE INTO AIDS THERAPY".
description: Source: http://www.calames.abes.fr/pub/ms/Calames-20193111133930913
In vitro antioxidant potential and in vivo effects of Schinus terebinthifolia Raddi leaf extract in diabetic rats and determination of chemical composition by HPLC-ESI-MS/MS
Creators: name: Iwanaga, Camila Cristina
name: Ferreira, Lilian Dos Anjos Oliveira
name: Bernuci, Karine Zanoli
name: Fernandez, Carla Maria Mariano
name: Lorenzetti, Fabiana Brusco
name: Sehaber, Camila Caviquioli
name: Frez, Flávia Cristina Vieira
name: Bernardes, Sara Santos
name: Gean Pier Panizzon
name: Giani Andrea Linde
name: Vieira, Maria Do Carmo
name: Zanoni, Jacqueline Nelisis
name: Diógenes Aparício Garcia Cortez
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Pharmacology
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: Ecology
subject: Immunology
subject: FOS: Clinical medicine

description: The present study investigated the in vitro and in vivo antioxidant potential and phytochemical composition of Schinus terebinthifolia, which is widely used in folk medicine for various therapeutic purposes. The in vitro analyses indicated that the hydroethanolic extract (HE) had 312.50 ± 0.50 mg GAE/g of total phenols. It also presented anti-DPPH• and anti-ABTS•+ activity, reduced phosphomolybden and metal ions and blocked the bleaching of β-carotene. The HE at concentrations of 3.0 and 2.0 μg/mL had TRAP values of 2.223 ± 0.018 and 1.894 ± 0.026 μM Trolox, respectively. The HE increased the availability of antioxidants in plasma in treated animals in vivo. HPLC-ESI-MS/MS indicated the presence of 11 phenols: cumaric acid, (+)-catechin, myricetin-3-O-glicuronide, kaempferol-3-O-glucoside, myricetin, myricitrin, quercetin, gallic acid, methyl galate, pentagalloyl glucose and ethyl galate. Thus, S. terebinthifolia has potential for the prevention or treatment of diseases that are related to oxidative stress, such as diabetes mellitus.
Time Fractional Quantum Mechanics
Creators: name: Laskin, Nick
Publisher: name: arXiv
Year: 2017
Subjects: subject: General Physics (physics.gen-ph)
subject: FOS: Physical sciences

description: A time fractional quantum framework has been introduced into quantum mechanics. A new version of the space-time fractional Schrödinger equation has been launched. The introduced space-time fractional Schrödinger equation has a new scale parameter, which is a fractional generalization of Planck's constant in quantum physics. It has been shown that the presence of a time fractional time derivative in the space-time fractional Schrödinger equation significantly impacts quantum mechanical fundamentals. Time fractional quantum mechanical operators of coordinate, momentum and angular momentum were defined and their commutation relationships were established. The pseudo-Hamilton operator was introduced and its Hermicity has been proven. Two new functions related to the Mittag-Leffler function have been introduced to solve the space-time fractional Schrödinger equation. Energy of a time fractional quantum system has been defined and calculated in terms of the newly introduced functions. It has been found that in the framework of time fractional quantum mechanics there are no stationary states, and the eigenvalues of the pseudo-Hamilton operator are not the energy levels of the time fractional quantum system. A free particle solution to the space-time fractional Schrödinger equation was found. A free particle space-time fractional quantum mechanical kernel has been found and expressed in terms of the H-function. Renormalization properties of a free particle solution and the space-time fractional quantum kernel were established. Some particular cases of time fractional quantum mechanics have been analyzed and discussed.
description: 36 pages
Dynamical Mass Generation in Pseudo Quantum Electrodynamics with Four-Fermion Interactions
Creators: name: Alves, Van Sérgio
name: Junior, Reginaldo O. C.
name: Marino, E. C.
name: Nascimento, Leandro O.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: FOS: Physical sciences

description: We describe dynamical symmetry breaking in a system of massless Dirac fermions with both electromagnetic and four-fermion interactions in (2+1) dimensions. The former is described by the Pseudo Quantum Electrodynamics (PQED) and the latter is given by the so-called Gross-Neveu action. We apply the Hubbard-Stratonovich transformation and the large$-N_f$ expansion in our model to obtain a Yukawa action. Thereafter, the presence of a symmetry broken phase is inferred from the non-perturbative Schwinger-Dyson equation for the electron propagator. This is the physical solution whenever the fine-structure constant is larger than a critical value $α_c(D N_f)$. In particular, we obtain the critical coupling constant $α_c\approx 0.36$ for $D N_f=8$., where $D=2,4$ corresponds to the SU(2) and SU(4) cases, respectively, and $N_f$ is the flavor number. Our results show a decreasing of the critical coupling constant in comparison with the case of pure electromagnetic interaction, thus yielding a more favorable scenario for the occurrence of dynamical symmetry breaking. For two-dimensional materials,in application in condensed matter systems, it implies an energy gap at the Dirac points or valleys of the honeycomb lattice.
description: 9 pages, 3 figures
Obtaining geographical competences through online cartography of familiar and unfamiliar urban heritage: lessons from student workshops
Creators: name: Martínez-Hernández, Carlos
name: Stoffelen, Arie
name: Piskorski, Radosław
Publisher: name: Taylor & Francis
Year: 2022
Subjects: subject: Genetics
subject: FOS: Biological sciences
subject: Molecular Biology
subject: Neuroscience
subject: Environmental Sciences not elsewhere classified
subject: Ecology
subject: Cancer
subject: Science Policy
subject: Mental Health

description: In times of the COVID-19 pandemic, teachers on all levels have had to adapt to an online or hybrid teaching environment. People in geography, a discipline that traditionally values field trips to connect theory to practice, have had to find online alternatives for educational activities that normally would have taken place in the field. This has led to several innovative practices, which, however, have only to a limited degree been purposively tested for efficacy because of the ad-hoc, enforced nature of the required changes. This project deals with this issue by studying, through student workshops dealing with the creation of online didactic walking routes in two cities, how students can obtain specific geographical competences such as interpreting different historical layers that collectively shape the current urban fabric through online cartography. We found that students reported clear improvements in geographical reasoning skills, regarding both GIS and heritage interpretation. There were no clear patterns regarding the role of familiarity with the studied city for the quality of the produced story maps. On final reflection, we argue that online cartographic exercises are a valuable addition to the geographers’ educational toolkit to bounce forward to a more resilient, reflective educational practice after the pandemic.
Modeling BSM effects on the Higgs transverse-momentum spectrum in an EFT approach
Creators: name: Grazzini, Massimiliano
name: Ilnicka, Agnieszka
name: Spira, Michael
name: Wiesemann, Marius
Publisher: name: arXiv
Year: 2016
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: FOS: Physical sciences

description: We consider the transverse-momentum distribution of a Higgs boson produced through gluon fusion in hadron collisions. At small transverse momenta, the large logarithmic terms are resummed up to next-to-leading-logarithmic (NLL) accuracy. The resummed computation is consistently matched to the next-to-leading-order (NLO) result valid at large transverse momenta. The ensuing Standard Model prediction is supplemented by possible new-physics effects parametrised through three dimension-six operators related to the modification of the top and bottom Yukawa couplings, and to the inclusion of a point-like Higgs-gluon coupling, respectively. We present resummed transverse-momentum spectra including the effect of these operators at NLL+NLO accuracy and study their impact on the shape of the distribution. We find that such modifications, while affecting the total rate within the current uncertainties, can lead to significant distortions of the spectrum. The proper parametrization of such effects becomes increasingly important for experimental analyses in Run II of the LHC.
Highly responsive ground state of PbTaSe$_2$: structural phase transition and evolution of superconductivity under pressure
Creators: name: Kaluarachchi, Udhara
name: Deng, Yuhang
name: Besser, Matthew F.
name: Sun, Kewei
name: Zhou, Lin
name: Nguyen, Manh Cuong
name: Yuan, Zhujun
name: Zhang, Chenglong
name: Schilling, James S.
name: Kramer, Matthew J.
name: Jia, Shuang
name: Wang, Cai-Zhuang
name: Ho, Kai-Ming
name: Canfield, Paul C.
name: Bud'ko, Sergey L.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: Transport and magnetic studies of PbTaSe$_2$ under pressure suggest existence of two superconducting phases with the low temperature phase boundary at $\sim 0.25$ GPa that is defined by a very sharp, first order, phase transition. The first order phase transition line can be followed via pressure dependent resistivity measurements, and is found to be near 0.12 GPa near room temperature. Transmission electron microscopy and x-ray diffraction at elevated temperatures confirm that this first order phase transition is structural and occurs at ambient pressure near $\sim 425$ K. The new, high temperature / high pressure phase has a similar crystal structure and slightly lower unit cell volume relative to the ambient pressure, room temperature structure. Based on first-principles calculations this structure is suggested to be obtained by shifting the Pb atoms from the $1a$ to $1e$ Wyckoff position without changing the positions of Ta and Se atoms. PbTaSe$_2$ has an exceptionally pressure sensitive, structural phase transition with $ΔT_s/ΔP \approx - 1700$ K/GPa near 4 K, this first order transition causes an $\sim 1$ K ($\sim 25 \%$) step - like decrease in $T_c$ as pressure is increased through 0.25 GPa.
Multivalent glycan arrays
Creators: name: Mende, Marco
name: Bordoni, Vittorio
name: Tsouka, Alexandra
name: Loeffler, Felix F.
name: Delbianco, Martina
name: Seeberger, Peter H.
Publisher: name: Freie Universität Berlin
Year: 2019
Subjects: subject: Glycan microarrays
subject: 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

description: Glycan microarrays have become a powerful technology to study biological processes, such as cell–cell interaction, inflammation, and infections. Yet, several challenges, especially in multivalent display, remain. In this introductory lecture we discuss the state-of-the-art glycan microarray technology, with emphasis on novel approaches to access collections of pure glycans and their immobilization on surfaces. Future directions to mimic the natural glycan presentation on an array format, as well as in situ generation of combinatorial glycan collections, are discussed.
Senna occidentalis (L.) Link and Senna hirsuta (L.) H. S. Irwin & Barneby: constituents of fruit essential oils and antimicrobial activity
Creators: name: Essien, Emmanuel E.
name: Thomas, Paul S.
name: Ascrizzi, Roberta
name: Setzer, William N.
name: Flamini, Guido
Publisher: name: Taylor & Francis
Year: 2018
Subjects: subject: Biochemistry
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: 59999 Environmental Sciences not elsewhere classified
subject: FOS: Earth and related environmental sciences
subject: 39999 Chemical Sciences not elsewhere classified
subject: FOS: Chemical sciences
subject: 69999 Biological Sciences not elsewhere classified
subject: 60506 Virology

description: Senna occidentalis and S. hirsuta are mostly gathered from the wild for medicinal use and have a disagreeable odour when crushed. The volatile oils isolated from fresh fruits of S. occidentalis and S. hirsuta were subjected to gas chromatography (GC), gas chromatography-mass spectrometry (GC-MS) and antimicrobial assays. GC and GC-MS analyses permitted the identification of 58 constituents. S. occidentalis oil was dominated by cyperene (10.8%), β-caryophyllene (10.4%), limonene (8.0%) and caryophyllene oxide (6.8%). The main components of S. hirsuta fruit oil were benzyl benzoate (24.7%), τ-cadinol (18.9%), 2,5-dimethoxy-p-cymene (14.6%) and β-caryophyllene (5.1%). S. occidentalis fruit oil exhibited better antimicrobial activity (MIC 78–312 μg/mL) against Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Aspergillus niger compared with S. hirsuta oil. The compositions and the activities of the fruit essential oils of S. occidentalis and S. hirsuta are reported for the first time.