cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Pyrocarbon Interposition Arthroplasty for The Thumb Carpo-Metacarpal Joint Osteoarthritis – mid to long term outcome analysis
Creators: name: Cerovac, Sonja
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: thumb
subject: basal joint
subject: arthritis
subject: interposition arthroplasty
subject: pyrocarbon
subject: 610 Medical sciences; Medicine

description: Objectives/Interrogation: This talk presents a mid to long-term result and operative technique on use of a pyrocarbon, non-anatomical implant for arthrosis of the first carpo-metacarpal joint (CMCJ) arthritis. Methods: Data was collected prospectively for 25 patients (average age 56) with [for full text, please go to the a.m. URL]
description: 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT)
Anomalous diffusion in run-and-tumble motion
Creators: name: Thiel, Felix
name: Schimansky-Geier, Lutz
name: Sokolov, Igor M.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Biological Physics (physics.bio-ph)
subject: FOS: Physical sciences

description: A random walk scheme, consisting of alternating phases of regular Brownian motion and Lévy walks, is proposed as a model for run-and-tumble bacterial motion. Within the continuous-time random walk approach we obtain the long-time and short-time behavior of the mean squared displacement of the walker as depending on the properties of dwelling time distribution in each phase. Depending on these distributions, normal diffusion, superdiffusion and ballistic spreading may arise.
description: 4 pages, 2 figures
title: Changes in joint distance during flexion and abduction of the thumb carpometacarpal joint
Creators: name: Nakada, Mika
name: Tada, Kaoru
name: Nakajima, Tadahiro
name: Matsuta, Masashi
name: Tsuchiya, Hiroyuki
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: thumb carpometacarpal joint
subject: joint distance
subject: boimechanics
subject: 610 Medical sciences; Medicine

description: Objectives/Interrogation: Although osteoarthritis of the thumb carpometacarpal (CMC) joint is common, the effect of thumb movement at the joint surface remains unclear. The purpose of this study was to examine the changes in joint distance during flexion and abduction of the thumb by computed tomography[for full text, please go to the a.m. URL]
description: 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT)
Two new naphthoate derivatives from Morinda officinalis
Creators: name: Zhai, Hui-Juan
name: Ye, Guo-Hua
name: Xue, Jun-Juan
name: Yu, Jin-Hai
name: Zhang, Yu-Ying
name: Zhang, Hua
Publisher: name: Taylor & Francis
Year: 2019
Subjects: subject: Biochemistry
subject: Neuroscience
subject: Pharmacology
subject: Environmental Sciences not elsewhere classified
subject: Chemical Sciences not elsewhere classified
subject: Biological Sciences not elsewhere classified
subject: Plant Biology
subject: FOS: Biological sciences

description: Two new naphthoate derivatives, including a symmetrical dimer (1) and a monomer (2), were separated from the roots of Morinda officinalis var. hirsuta. Their structures were characterized on the basis of spectroscopic means especially MS and NMR methods. Biological evaluations revealed that the two compounds did not show inhibition against both cholinesterases AChE and BChE, while the dimer (1) did exhibit moderate growth inhibitory activity toward one human osteosarcoma cell line U2OS with an IC50 value of 18.5 ± 1.1 μM.
Approach for describing spatial dynamics of quantum light-matter interaction in dispersive dissipative media
Creators: name: Zyablovsky, A. A.
name: Andrianov, E. S.
name: Nechepurenko, I. A.
name: Dorofeenko, A. V.
name: Pukhov, A. A.
name: Vinogradov, A. P.
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Solving the challenging problem of the amplification and generation of an electromagnetic field in nanostructures enables to implement many properties of the electromagnetic field at the nanoscale in novel practical applications. A first-principles quantum mechanical consideration of such a problem is sufficiently restricted by the exponentially large number of degrees of freedom, and does not allow the electromagnetic field dynamics to be described if it involves a high number of interacting atoms and modes of the electromagnetic field. Conversely, the classical description of electromagnetic fields is incorrect at the nanoscale due to the high level of quantum fluctuations connected to high dissipation and noise levels. In this paper, we develop the framework with a significantly reduced number of degrees of freedom, which describes the quantum spatial dynamics of electromagnetic fields interacting with atoms. As an example, we consider the interaction between atoms placed in a metallic subwavelength groove, and demonstrate that a spontaneously excited electromagnetic pulse propagates with the group velocity. The developed approach may be exploited to describe non-uniform amplification and propagation of electromagnetic fields in arbitrary dispersive dissipative systems.
Pearcey solitons in curved nonlinear photonic caustic lattices
Creators: name: Zannotti, Alessandro
name: Rüschenbaum, Matthias
name: Denz, Cornelia
Publisher: name: arXiv
Year: 2017
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: Controlling artificial Pearcey and swallowtail beams allows realizing caustic lattices in nonlinear photosensitive media at very low light intensities. We examine their functionality as 2D and 3D waveguiding structures, and show the potential of exploiting these lattices as a linear beam splitter, which we name a Pearcey-Y-splitter. For symmetrized Pearcey beams as auto-focusing beams, the formation of solitons in focusing nonlinearity is observed. Our original approach represents the first realization of caustic photonic lattices and can directly be applied in signal processing, microscopy and material lithography.
Additional file 1 of Regulation of DNA methylation on key parasitism genes of Cysticercus cellulosae revealed by integrative epigenomic-transcriptomic analyses
Creators: name: Wang, Xinrui
name: Song, Weiyi
name: Ji, Guanyu
name: Song, Yining
name: Liu, Xiaolei
name: Luo, Xuenong
name: Liu, Mingyuan
name: Sun, Shumin
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 1: Figure S1. Phylogenetic tree of DNMT proteins.
title: Costochondral interposition arthroplasty in treatment of basal thumb arthritis
Creators: name: Mandziuk, Agnieszka
name: Nicoloff, Miho
name: Cleenewerck, Simon
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: Basal thumb arthritis
subject: 610 Medical sciences; Medicine

description: Objectives/Interrogation: Trapeziectomy remains gold standard in treatment of basal thumb arthritis. This presentation handles the technique of costal cartilage interposition arthroplasty with special attention to the additional arthritis of the scaphotrapezoidal joint. Methods: The main[for full text, please go to the a.m. URL]
description: 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT)
title: An alternative direction of the borehole for ligament reconstruction after resection of the trapezium in basal joint osteoarthrosis: a comparative study in 32 cadaver hands
Creators: name: Van Bömmel, Leon
name: Könneker, Sören
name: Vogt, Peter M.
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: Basal joint osteoarthrosis
subject: trapeziectomy
subject: ligament reconstruction
subject: 610 Medical sciences; Medicine

description: Objectives/Interrogation: Ligament reconstruction of the basal joint of the thumb after trapeziectomy is a common technique in patients with osteoarthrosis. For this procedure different donor tendons and techniques are described. However, there is no exact report about the best borehole direction[for full text, please go to the a.m. URL]
description: 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT)
Prediction of Final Phosphorus Content of Steel in a Scrap-Based Electric Arc Furnace Using Artificial Neural Networks
Creators: name: Azzaz, Riadh
name: Hurel, Valentin
name: Menard, Patrice
name: Jahazi, Mohammad
name: Kahou, Samira Ebrahimi
name: Moosavi-Khoonsari, Elmira
Publisher: name: arXiv
Year: 2024
Subjects: subject: Machine Learning (cs.LG)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Computer and information sciences
subject: FOS: Physical sciences

description: The scrap-based electric arc furnace process is expected to capture a significant share of the steel market in the future due to its potential for reducing environmental impacts through steel recycling. However, managing impurities, particularly phosphorus, remains a challenge. This study aims to develop a machine learning model to estimate the steel phosphorus content at the end of the process based on input parameters. Data were collected over two years from a steel plant, focusing on the chemical composition and weight of the scrap, the volume of oxygen injected, and process duration. After preprocessing the data, several machine learning models were evaluated, with the artificial neural network (ANN) emerging as the most effective. The best ANN model included four hidden layers. The model was trained for 500 epochs with a batch size of 50. The best model achieves a mean square error (MSE) of 0.000016, a root-mean-square error (RMSE) of 0.0049998, a coefficient of determination (R2) of 99.96%, and a correlation coefficient (r) of 99.98%. Notably, the model achieved a 100% hit rate for predicting phosphorus content within +-0.001 wt% (+-10 ppm). These results demonstrate that the optimized ANN model offers accurate predictions for the steel final phosphorus content.
description: 53 pages, 8 figures
Additional file 2 of Regulation of DNA methylation on key parasitism genes of Cysticercus cellulosae revealed by integrative epigenomic-transcriptomic analyses
Creators: name: Wang, Xinrui
name: Song, Weiyi
name: Ji, Guanyu
name: Song, Yining
name: Liu, Xiaolei
name: Luo, Xuenong
name: Liu, Mingyuan
name: Sun, Shumin
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 2: Figure S2. Phylogenetic tree of mbd proteins.
Lie symmetries of nonlinear parabolic-elliptic systems and their application to a tumour growth model
Creators: name: Cherniha, Roman
name: Davydovych, Vasyl'
name: King, John R.
Publisher: name: arXiv
Year: 2017
Subjects: subject: Mathematical Physics (math-ph)
subject: FOS: Physical sciences

description: A generalisation of the Lie symmetry method is applied to classify a coupled system of reaction-diffusion equations wherein the nonlinearities involve arbitrary functions in the limit case in which one equation of the pair is quasi-steady but the other not. A complete Lie symmetry classification, including a number of the cases characterised being unlikely to be identified purely by intuition, is obtained. Notably, in addition to the symmetry analysis of the PDEs themselves, the approach is extended to allow the derivation of exact solutions to specific moving-boundary problems motivated by biological applications tumour growth). Graphical representations of the solutions are provided and biological interpretation addressed briefly. The results are generalised on multi-dimensional case under assumption of radially symmetrical shape of the tumour.
title: Is hand dominance and a history of hand injury associated with a higher prevalence of hand pain and osteoarthritis in cricketers?
Creators: name: Shah, Karishma
name: Furniss, Dominic
name: Peirce, Nicholas
name: Arden, Nigel
name: Filbay, Stephanie
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: Hand
subject: Osteoarthritis
subject: Pain
subject: Injury
subject: Dominance
subject: Cricket
subject: 610 Medical sciences; Medicine

description: Objectives/Interrogation: Hand osteoarthritis (HOA) is the most common form of OA. However, factors associated with hand pain and HOA in current and former sport participants is poorly understood. We aimed to determine if hand pain and HOA are more prevalent in (i) cricketers with a history of [for full text, please go to the a.m. URL]
description: 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT)
Anemia and adverse outcomes in a chronic obstructive pulmonary disease population with a high burden of comorbidities an analysis from SPIROMICS
Creators: name:  Lambert, A.A.
name:  Paul, G.G.
name:  Michael Wells, J.
name:  Wise, R.A.
name:  Woo, J.
name: O'Neal, W.K.
name:  Martinez, C.
name:  Psoter, K.J.
name:  Sidhaye, V.K.
name:  Paulin, L.M.
name:  Martinez, F.J.
name:  Kanner, R.E.
name: SPIROMICS Investigators
name:  Labaki, W.W.
name:  Doerschuk, C.M.
name: Graham Barr, R.
name: Hansel, N.N.
name:  Han, M.K.
name:  Fawzy, A.
name: Putcha, N.
Publisher: name: American Thoracic Society
Year: 2018

description: Rationale: Chronic obstructive pulmonary disease (COPD) is a common cause of morbidity and associated with a significant burden of comorbidities. Although anemia is associated with adverse outcomes in COPD, its contribution to outcomes in individuals with other comorbid chronic diseases is not well understood. Objectives: This study examines the association of anemia with outcomes in a large, well-characterized COPD cohort, and attempts to understand the contribution of anemia to outcomes and phenotypes in individuals with other comorbidities. Methods: Participants with COPD from SPIROMICS (the Subpopulations and Intermediate Outcome Measures in COPD Study) were analyzed in adjusted models to determine the associations of normocytic anemia with clinical outcomes, computed tomographic measures, and biomarkers. Analysis was additionally performed to understand the independence and possible interactions related to cardiac and metabolic comorbidities. Results: A total of 1,789 individuals with COPD from SPIROMICS had data on hemoglobin, and of these 7.5% (n = 135) were found to have normocytic anemia. Anemic participants were older with worse airflow obstruction, a higher proportion of them were African Americans, and they had a higher burden of cardiac and metabolic comorbidities. Anemia was strongly associated with 6-minute walk distance (b, 261.43; 95% confidence interval [CI], 285.11 to 237.75), modified Medical Research Council dyspnea questionnaire (b, 0.27; 95% CI, 0.11-0.44), and St. George's Respiratory Questionnaire (b, 3.90; 95% CI, 1.09-6.71), and these adjusted associations were stronger among those with two or more cardiac and metabolic comorbidities. Anemia was associated with higher levels of serum C-reactive protein, soluble receptor for advanced glycosylation endproducts, and epithelial cadherin-1, findings that persisted when in those with a high burden of comorbidities. Conclusions: Anemia is associated with worse exercise capacity, greater dyspnea, and greater disease severity among adults with COPD, particularly among those with comorbid chronic cardiac and metabolic diseases. The biomarkers found in anemic individuals suggest inflammation, lung tissue injury, and oxidative stress as possible pathways for the adverse correlations of anemia with outcomes in COPD; however, substantial further study is required to better understand these potential mechanisms.
title: Functional outcome of distal interphalangeal joint arthrodesis
Creators: name: Oh, Jinchul
name: Kang, Ho-Jung
name: Choi, Yun-rak
name: Koh, Il-hyun
name: Oh, Won-taek
name: Hong, JungJun
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: Functional outcome
subject: osteoarhtritis of DIPJ
subject: arthrodesis of DIPJ
subject: 610 Medical sciences; Medicine

description: Objectives/Interrogation: Distal interphalangeal joint (DIPJ) arthrodesis can be used to treat pain, deformity, or instability associated with arthritis of DIPJ. It is not common procedure, but effective for creating a painless stable joint. The purpose of this study was to analyze DIPJ pathologies,[for full text, please go to the a.m. URL]
description: 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT)
Lower serum IgA is associated with COPD exacerbation risk in SPIROMICS
Creators: name: Han, M.K.
name: Azar, A.
name: Kanner, R.E.
name: Fawzy, A.
name: Dransfield, M.T.
name: Lambert, A.A.
name: Hansel, N.N.
name: Paine, R.
name: Wise, R.A.
name: Comellas, A.P.
name: Martinez, F.J.
name: Barr, R.G.
name: Paulin, L.M.
name: Paul, G.G.
name: O'Neal, W.K.
name: Bowler, R.P.
name: Woodruff, P.G.
name: Curtis, J.L.
name: Putcha, N.
name: Drummond, M.B.
Publisher: name: Public Library of Science
Year: 2018

description: Background Decreased but measurable serum IgA levels (70 mg/dL) have been associated with risk for infections in some populations, but are unstudied in COPD. This study tested the hypothesis that subnormal serum IgA levels would be associated with exacerbation risk in COPD. Methods Data were analyzed from 1,049 COPD participants from the observational cohort study SPIROMICS (535 (51%) women; mean age 66.1 (SD 7.8), 338 (32%) current smokers) who had baseline serum IgA measured using the Myriad RBM biomarker discovery platform. Exacerbation data was collected prospectively (mean 944.3 (SD 281.3) days), and adjusted linear, logistic and zero-inflated negative binomial regressions were performed. Results Mean IgA was 269.1 mg/dL (SD 150.9). One individual had deficient levels of serum IgA (<7 mg/dL) and 25 (2.4%) had IgA level 70 mg/dL. Participants with IgA 70 mg/dL were younger (62 vs. 66 years, p = 0.01) but otherwise similar to those with higher IgA. In adjusted models, IgA 70 mg/dL was associated with higher exacerbation incidence rates (IRR 1.71, 95% CI 1.01-2.87, p = 0.044) and greater risk for any severe exacerbation (OR 2.99, 95% CI 1.30-6.94, p = 0.010). In adjusted models among those in the lowest decile (<120 mg/ dL), each 10 mg/dL decrement in IgA (analyzed continuously) was associated with more exacerbations during follow-up (β 0.24, 95% CI 0.017-0.46, p = 0.035). Conclusions Subnormal serum IgA levels were associated with increased risk for acute exacerbations, supporting mildly impaired IgA levels as a contributing factor in COPD morbidity. Additionally, a dose-response relationship between lower serum IgA and number of exacerbations was found among individuals with serum IgA in the lowest decile, further supporting the link between serum IgA and exacerbation risk. Future COPD studies should more comprehensively characterize immune status to define the clinical relevance of these findings and their potential for therapeutic correction.
Cystic fibrosis disease modifiers: Complex genetics defines the phenotypic diversity in a monogenic disease
Creators: name: O'Neal, W.K.
name: Knowles, M.R.
Publisher: name: Annual Reviews Inc.
Year: 2018

description: In many respects, genetic studies in cystic fibrosis (CF) serve as a paradigm for a human Mendelian genetic success story. From recognition of the condition as a heritable pathological entity to implementation of personalized treatments based on genetic findings, this multistep pathway of progress has focused on the genetic underpinnings of CF clinical disease. Along this path was the recognition that not all CFTR gene mutations produce the same disease and the recognition of the complex, multifactorial nature of CF genotype-phenotype relationships. The non-CFTR genetic components (gene modifiers) that contribute to variation in phenotype are the focus of this review. A multifaceted approach involving candidate gene studies, genome-wide association studies, and gene expression studies has revealed significant gene modifiers for multiple CF phenotypes. The bold challenges for the future are to integrate the findings into our understanding of CF pathogenesis and to use the knowledge to develop novel therapies.
Additional file 3 of Regulation of DNA methylation on key parasitism genes of Cysticercus cellulosae revealed by integrative epigenomic-transcriptomic analyses
Creators: name: Wang, Xinrui
name: Song, Weiyi
name: Ji, Guanyu
name: Song, Yining
name: Liu, Xiaolei
name: Luo, Xuenong
name: Liu, Mingyuan
name: Sun, Shumin
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 3: Figure S3. Patterns and chromosomal distribution of DNA methylation in T. solium.
Membrane Mucin Muc4 promotes blood cell association with tumor cells and mediates efficient metastasis in a mouse model of breast cancer
Creators: name: Stonebraker, J.R.
name: Wald, J.H.
name: Sweeney, C.
name: VanderVorst, K.
name: Borowsky, A.D.
name: Rowson-Hodel, A.R.
name: Carraway, K.L.
name: Hatakeyama, J.
name: Saldana, M.J.
name: O'Neal, W.K.
Publisher: name: Nature Publishing Group
Year: 2018

description: Mucin-4 (Muc4) is a large cell surface glycoprotein implicated in the protection and lubrication of epithelial structures. Previous studies suggest that aberrantly expressed Muc4 can influence the adhesiveness, proliferation, viability and invasiveness of cultured tumor cells, as well as the growth rate and metastatic efficiency of xenografted tumors. Although it has been suggested that one of the major mechanisms by which Muc4 potentiates tumor progression is via its engagement of the ErbB2/HER2 receptor tyrosine kinase, other mechanisms exist and remain to be delineated. Moreover, the requirement for endogenous Muc4 for tumor growth progression has not been previously explored in the context of gene ablation. To assess the contribution of endogenous Muc4 to mammary tumor growth properties, we first created a genetically engineered mouse line lacking functional Muc4 (Muc4 ko), and then crossed these animals with the NDL (Neu DeLetion mutant) model of ErbB2-induced mammary tumorigenesis. We observed that Muc4 ko animals are fertile and develop normally, and adult mice exhibit no overt tissue abnormalities. In tumor studies, we observed that although some markers of tumor growth such as vascularity and cyclin D1 expression are suppressed, primary mammary tumors from Muc4 ko /NDL female mice exhibit similar latencies and growth rates as Muc4 wt /NDL animals. However, the presence of lung metastases is markedly suppressed in Muc4 ko /NDL mice. Interestingly, histological analysis of lung lesions from Muc4 ko /NDL mice revealed a reduced association of disseminated cells with platelets and white blood cells. Moreover, isolated cells derived from Muc4 ko /NDL tumors interact with fewer blood cells when injected directly into the vasculature or diluted into blood from wild type mice. We further observed that blood cells more efficiently promote the viability of non-adherent Muc4 wt /NDL cells than Muc4 ko /NDL cells. Together, our observations suggest that Muc4 may facilitate metastasis by promoting the association of circulating tumor cells with blood cells to augment tumor cell survival in circulation.
title: Wide-awake local anesthesia no tourniquet (WALANT) proximal row carpectomy
Creators: name: Muller, Camillo Theo
name: Deboccard, Olivier
name: Raffoul, Wassim
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: WALANT proximal row carpectomy
subject: 610 Medical sciences; Medicine

description: Objectives/Interrogation: Wide-awake local anesthesia using no tourniquet (WALANT) hand surgery is a still gaining popularity. WALANT has been used by hand surgeons when operating on skin, nerve entrapments, tendons and bones. The limits of hand surgery under local anesthesia are permanently being[for full text, please go to the a.m. URL]
description: 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT)
Novel variation at chr11p13 associated with cystic fibrosis lung disease severity
Creators: name: Dang, H.
name: Knowles, M.R.
name: Pace, R.G.
name: O'Neal, W.K.
name: Gallins, P.J.
name: Cutting, G.R.
name: Corvol, H.
name: Drumm, M.L.
name: Strug, L.J.
name: Stonebraker, J.R.
name: Guo, X.-L.
Publisher: name: Nature Publishing Group
Year: 2016

description: Published genome-wide association studies (GWASs) identified an intergenic region with regulatory features on chr11p13 associated with cystic fibrosis (CF) lung disease severity. Targeted resequencing in n=377, followed by imputation to n=6,365 CF subjects, was used to identify unrecognized genetic variants (including indels and microsatellite repeats) associated with phenotype. Highly significant associations were in strong linkage disequilibrium and were seen only in Phe508del homozygous CF subjects, indicating a CFTR genotype-specific mechanism.
title: Trapeziometacarpal arthroplasty – Case report with Ball and socket type prostheses
Creators: name: Cayon, Fidel
name: Alegria, Gabriel
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: Trapeziometacarpal joint
subject: Eaton-Glickel Classification
subject: Ball and Socket Prostheses
subject: 610 Medical sciences; Medicine

description: Objective: To evaluate the pain, strength and mobility arches in the trapeziometacarpal joint in patients undergoing MAIA Prosthesis (Group Lepine, France) placement by the same hand surgeon from January 1, 2015 to June 30, 2018 Methods: A retrospective study of case reports was carried out, taking[for full text, please go to the a.m. URL]
description: 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT)
title: Table des matières_Le Café, le chocolat et le thé, guide de l'acheteur, du vendeur et de l'amateur
Creators: name: AmateurS
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020

description: Table des matières
Airway epithelial inflammation-induced endoplasmic reticulum Ca2+ store expansion is mediated by X-box binding protein-1
Creators: name: Ribeiro, C.P.
name: O'Neal, W.K.
name: Olsen, J.C.
name: Martino, M.E.B.
name: Wolfgang, M.C.
name: Fulcher, N.B.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Inflamed cystic fibrosis (CF) human bronchial epithelia (HBE), or normal HBE exposed to supernatant from mucopurulent material (SMM) from CF airways, exhibit endoplasmic reticulum (ER)/Ca2+ store expansion and amplified Ca2-mediated inflammation. HBE inflammation triggers an unfolded protein response (UPR) coupled to mRNA splicing of X-box binding protein-1 (XBP-1). Because spliced XBP-1 (XBP-1s) promotes ER expansion in other cellular models, we hypothesized that XBP-1s is responsible for the ER/Ca2+ store expansion in inflamed HBE. XBP-1s was increased in freshly isolated infected/inflamed CF in comparison with normal HBE. The link between airway epithelial inflammation, XBP-1s, and ER/Ca2+ store expansion was then addressed in murine airways challenged with phosphate-buffered saline or Pseudomonas aeruginosa. P. aeruginosa-challenged mice exhibited airway epithelial ER/Ca2+ store expansion, which correlated with airway inflammation. P. aeruginosa-induced airway inflammation triggered XBP-1s in ER stress-activated indicator (ERAI) mice. To evaluate the functional role of XBP-1s in airway inflammation linked to ER/Ca2+ store expansion, control, XBP-1s, or dominant negative XBP-1 (DN-XBP-1) stably expressing 16HBE14o- cell lines were used. Studies with cells transfected with an unfolded protein response element (UPRE) luciferase reporter plasmid confirmed that the UPRE was activated or inhibited by expression of XBP-1s or DN-XBP-1, respectively. Expression of XBP-1s induced ER/Ca2+ store expansion and potentiated bradykinin-increased interleukin (IL)-8 secretion, whereas expression of DN-XBP-1 inhibited bradykinin-dependent IL-8 secretion. In addition, expression of DN-XBP-1 blunted SMM-induced ER/Ca2+ store expansion and SMM-induced IL-8 secretion. These findings suggest that, in inflamed HBE, XBP-1s is responsible for the ER/Ca2+ store expansion that confers amplification of Ca2+-dependent inflammatory responses.
title: Tetraplegia Hand Surgery. The Cypriot Perspective
Creators: name: Kritiotis, Constantinos
name: Fakonti, Christiana
name: Friden, Jan
name: Koch Borner, Sabrina
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: tetraplegia
subject: tetrahand
subject: tendon transfer
subject: ALPHABET
subject: posterior deltoid
subject: triceps
subject: spinal cord
subject: 610 Medical sciences; Medicine

description: Objectives/Interrogation: We present the creation of the Cypriot Tetraplegia Hand Surgery Service, the acceptance in the SCI patients community as well as our results thus far. Methods: All tetraplegic patients who express an interest for reconstructive procedures are referred and evaluated[for full text, please go to the a.m. URL]
description: 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT)
Investigation of the possible role of a novel gene, DPCD, in primary ciliary dyskinesia
Creators: name: Ostrowski, L.E.
name: Zariwala, M.
name: O'Neal, W.K.
name: Noone, P.G.
name: Knowles, M.R.
name: Leigh, M.W.
Publisher: name: American Thoracic Society
Year: 2004

description: Primary ciliary dyskinesia (PCD) is an autosomal recessive disease caused by mutations that affect the proper function of cilia. Recently, deletion of DNA polymerase λ (Poll) in mice produced a phenotype characteristic of PCD (Kobayashi et al., 2002, Mol. Cell. Biol. 22:2769-2776). Because it is unclear how a mutation in a DNA polymerase would result in a specific defect in axonemes, the targeting construct was examined further. Analysis of the genomic region surrounding the Poll gene revealed an uncharacterized gene, named Dpcd, that is predicted to be transcribed from the opposite strand relative to Poll. The deletion of Poll would also remove the first exon of Dpcd. Because it is possible that the PCD phenotype observed is due to the absence of either gene, the expression of these genes during ciliogenesis of human airway epithelial cells was examined. Northern analysis demonstrated that DPCD expression increases during ciliated cell differentiation; the expression of POLL decreases. To examine directly whether DPCD is mutated in cases of human PCD, the complete coding sequence of DPCD was sequenced from 51 unrelated PCD patients. No disease-causing mutations were confirmed; however, one variant could not be excluded. Therefore, DPCD remains a novel candidate gene for PCD.
Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons
Creators: name: Aguilar-Córdova, E.
name: Leland, M.
name: Graham, F.L.
name: Parks, R.J.
name: Velji, R.
name: Morral, N.
name: Kaplan, J.
name: Dee Carey, K.
name: Rice, K.
name: Kochanek, S.
name: O'Neal, W.
name: Wadsworth, S.
name: Beaudet, A.L.
name: Zhou, H.
name: Piedra, P.A.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 1999

description: The efficiency of first-generation adenoviral vectors as gene delivery tools is often limited by the short duration of transgene expression, which can be related to immune responses and to toxic effects of viral proteins. In addition, readministration is usually ineffective unless the animals are immunocompromised or a different adenovirus serotype is used. Recently, adenoviral vectors devoid of all viral coding sequences (helper-dependent or gutless vectors) have been developed to avoid expression of viral proteins. In mice, liver-directed gene transfer with AdSTK109, a helper-dependent adenoviral (Ad) vector containing the human α1-antitrypsin (hAAT) gene, resulted in sustained expression for longer than 10 months with negligible toxicity to the liver. In the present report, we have examined the duration of expression of AdSTK109 in the liver of baboons and compared it to first- generation vectors expressing hAAT. Transgene expression was limited to approximately 3-5 months with the first-generation vectors. In contrast, administration of AdSTK109 resulted in transgene expression for longer than a year in two of three baboons. We have also investigated the feasibility of circumventing the humoral response to the virus by sequential administration of vectors of different serotypes. We found that the ineffectiveness of readministration due to the humoral response to an Ad5 first-generation vector was overcome by use of an Ad2-based vector expressing hAAT. These data suggest that long-term expression of transgenes should be possible by combining the reduced immunogenicity and toxicity of helper-dependent vectors with sequential delivery of vectors of different serotypes.
title: ADCO, Grènetier de Cîteaux : comptes (1497-1504) (11 H 1172), f. 00057
Creators: name: de la Côte-d'Or, Archives départementales
name: Archives Départementales De La Côte-D'Or
name: Petot, Frédérique
name: Projet CBMA
name: CBMA/CG21/F.PETOT/2019
Publisher: name: NAKALA - https://nakala.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2020
Subjects: subject: comptes
subject: Corpus Burgundiae Medii Aevi
subject: Chartes de la Bourgogne du Moyen Âge
subject: LaMOP
subject: Laboratoire de Médiévistique Occidentale de Paris

description: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172). Numérisation en mode image.
description: Relation: http://www.cbma-project.eu/
description: Bibliographic citation: Grènetier de Cîteaux : comptes (1497-1504), Archives départementales de la Côte-d'Or, (11 H 1172), f. 00057, in Projet CBMA - Corpus Burgundiae Medii Aevi \[Ressource en ligne\], https:// manuscrits.cbma-project.eu/
description: Provenance: https://www.geonames.org/3024876
description: Provenance: http://www.idref.fr/030974844/id
description: Provenance: abbaye de Cîteaux
description: Provenance: https://catalogue.bnf.fr/ark:/12148/cb12228351v
description: Provenance: http://www.wikidata.org/entity/Q843261
Lung cell-specific cre deleter mouse strains: Going back to move forward
Creators: name: O'Neal, W.K.
Publisher: name: American Thoracic Society
Year: 2017

description: The lung is highly complex, composed of multiple cell types. As such, the molecular dissection of pulmonary biology has been significantly supported by in vivo models. Genetic manipulations leading to transgenic overexpression or knockdown of specific genes in mammalian models, particularly mice, are commonplace in respiratory research. Although it is often informative to conduct genetic manipulations without consideration for tissue or cell type, such as in the generation of germline knockouts of genes to evaluate gene function, use of cell type–specific transgenic strains is often the only feasible approach to study lung-specific effects. Particularly powerful has been the development of inducible Crerecombinase transgenic mouse strains that are used to specifically delete genes of interest in cells of interest in an inducible fashion.
ОСОБЕННОСТИ ЭКОЛОГИЧЕСКОГО НОРМИРОВАНИЯ ЭНЕРГОГЕНЕРИРУЮЩИХ УСТАНОВОК НА РАЗЛИЧНЫХ ВИДАХ ТОПЛИВА
Creators: name: Нижников Александр Васильевич
name: Савенок Владимир Евгеньевич
Publisher: name: Вестник Витебского государственного технологического университета
Year: 2020
Subjects: НОРМАТИВ
ОЦЕНКА
ТОПЛИВО
УСТАНОВКА
ЭНЕРГИЯ

description: В связи с ограниченностью собственных энергоресурсов Республики Беларусь в хозяйственный оборот вовлекаются местные виды ТЭР, содержащие достаточное количество органических веществ (углерода) и имеющие необходимую теплоту сгорания для удовлетворения теплоэнергетических нужд. Целью данной работы было определение и выявление критериев, влияющих на оценку экологического ущерба окружающей среде при замещении природного газа местными видами топлива. Перевод энергогенерирующих установок на местные виды топлива (биотопливо), как альтернатива импортируемому природному газу приводит к увеличению выбросов загрязняющих веществ в атмосферный воздух на единицу установленной мощности. Считаем, что данный перевод должен сопровождаться разработкой мер, снижающих негативное воздействие на окружающую среду, которое возникает при эксплуатации топливосжигающих установок на местных видах топлива. При этом наряду с техническими мероприятиями, снижающими это воздействие, должна быть разработана нормативная база, обеспечивающая действенный контроль в этой области. Нами предлагается разработать эколого-энергетические нормативы, которые бы регламентировали выбросы загрязняющих веществ от различных топливосжигающих установок на единицу мощности вырабатываемой тепловой и (или) электрической энергии.
Additional file 4 of Regulation of DNA methylation on key parasitism genes of Cysticercus cellulosae revealed by integrative epigenomic-transcriptomic analyses
Creators: name: Wang, Xinrui
name: Song, Weiyi
name: Ji, Guanyu
name: Song, Yining
name: Liu, Xiaolei
name: Luo, Xuenong
name: Liu, Mingyuan
name: Sun, Shumin
Publisher: name: figshare
Year: 2021
Subjects: subject: Genetics
subject: FOS: Biological sciences

description: Additional file 4: Figure S4. DNA methylation patterns and chromosomal distribution.
Co-sputtered PtMnSb thin films and PtMnSb/Pt bilayers for spin-orbit torque investigations
Creators: name: Krieft, Jan
name: Mendil, Johannes
name: Aguirre, Myriam H.
name: Avci, Can O.
name: Klewe, Christoph
name: Rott, Karsten
name: Schmalhorst, Jan-Michael
name: Reiss, Günter
name: Gambardella, Pietro
name: Kuschel, Timo
Publisher: name: arXiv
Year: 2016
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: FOS: Physical sciences

description: The manipulation of the magnetization by spin-orbit torques (SOTs) has recently been extensively studied due to its potential for efficiently writing information in magnetic memories. Particular attention is paid to non-centrosymmetric systems with space inversion asymmetry, where SOTs emerge even in single-layer materials. The half-metallic half-Heusler PtMnSb is an interesting candidate for studies of this intrinsic SOT. Here, we report on the growth and epitaxial properties of PtMnSb thin films and PtMnSb/Pt bilayers deposited on MgO(001) substrates by dc magnetron co-sputtering at high temperature in ultra-high vacuum. The film properties were investigated by x-ray diffraction, x-ray reflectivity, atomic force microscopy, and electron microscopy. Thin PtMnSb films present a monocrystalline C1b phase with (001) orientation, coexisting at increasing thickness with a polycrystalline phase with (111) texture. Films thinner than about 5 nm grow in islands, whereas thicker films grow layer-by-layer, forming a perfect MgO/PtMnSb interface. The thin PtMnSb/Pt bilayers also show island growth and a defective transition zone, while thicker films grow layer-by-layer and Pt grows epitaxially on the half-Heusler compound without significant interdiffusion.
description: 5 pages, 4 figures
title: Grift Hand Spastic, Tetraplegic, and Obstetric Paralysis
Creators: name: Loda, Guillermo
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: 610 Medical sciences; Medicine

description: Personal Approach: Brief description of an anatomical analysis of "grift hand". Different and known surgical procedures, indications, suggestions, difficulties and complications are mentioned in this presentation. A new surgical procedure is presented so as to facilitate and minimize[for full text, please go to the a.m. URL]
description: 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT)
ТЕХНОГЕННЫЕ ПРОДУКТЫ ХИМИЧЕСКОЙ ВОДОПОДГОТОВКИ ТЕПЛОЭЛЕКТРОЦЕНТРАЛЕЙ КАК ДОБАВКА К КЛИНКЕРНЫМ КЕРАМИЧЕСКИМ МАТЕРИАЛАМ
Creators: name: Манак Павел Иванович
name: Ковчур Андрей Сергеевич
name: Гречаников Александр Викторович
name: Тимонов Иван Афанасьевич
Publisher: name: Вестник Витебского государственного технологического университета
Year: 2020
Subjects: КЛИНКЕР
КЛИНКЕРНАЯ ТРОТУАРНАЯ ПЛИТКА
ТЕХНОГЕННЫЕ ПРОДУКТЫ
ОСАДКИ ХИМИЧЕСКОЙ ВОДОПОДГОТОВКИ
ТЕПЛОЭЛЕКТРОЦЕНТРАЛИ
КЕРАМИЧЕСКИЙ КЛИНКЕРНЫЙ КИРПИЧ

description: Целью представленной работы является исследование возможности использования техногенных продуктов химической водоподготовки теплоэлектроцентралей в качестве добавки при изготовлении керамических клинкерных материалов. Проведенные на ОАО «Обольский керамический завод» исследования физико-механических свойств опытных образцов керамической клинкерной плитки показали возможность использования техногенных продуктов энергетического комплекса (осадков химической водоподготовки теплоэлектроцентралей) в качестве добавки при изготовлении керамических строительных материалов общего назначения. Добавка осадков химической водоподготовки позволяет уменьшить температуру обжига изделий, что важно в плане энергосбережения.
title: Managing Painful Wrist and Trapezio-Metacarpal Arthritis in Patients with SCI Using Surgical Joint Denervation
Creators: name: Gohritz, Andreas
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: wrist
subject: carpo-metacarpal
subject: join
subject: denervation
subject: paraplegia
subject: tetraplegia
subject: 610 Medical sciences; Medicine

description: Objectives/Interrogation: Patients with spinal cord injury (SCI) have an increased incidence of painful wrist and trapezio-metacarpal arthritis due to the accumulated long-term load on their upper extremity or post-traumatically. However, many of the affected individuals opt against standard bony[for full text, please go to the a.m. URL]
description: 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT)
title: Образ «галантной дамы» в изображении Пьера де Бурдея, аббата де Брантома
Creators: name: Быстрова, Владислава
Publisher: name: Новгородский государственный университет имени Ярослава Мудрого (НовГУ)
Year: 2022

description: В статье представлен анализ сочинений французского автора и придворного XVI в. Пьера де Бурдея, аббата де Брантома, реконструируется «ментальное состояние» высшего французского общества второй половины XVI в., на примере образа «галантной дамы». Кратко затрагивается происхождение термина «галантность». Освещаются этические представления Брантома о благородных женщинах и личный взгляд автора на социально-политическую сущность придворной жизни. Выделяются особенности социального положения женщины в эпоху Ренессанса, когда во Франции начался процесс феминизации королевского двора. Благородные дамы получают больше привилегий и возможность принимать участие в политической жизни государства. Отмечается, что под влиянием неоплатонизма появляется новый образ мышления и возникает феномен галантной любви, распространившийся в среде придворных.
title: Deltoid to triceps transfer in tetraplegic patients: The Stoke Mandeville experience
Creators: name: Song, Marie
name: Shirley, Rebecca
name: Heywood, Anthony
Publisher: name: German Medical Science GMS Publishing House
Year: 2020
Subjects: subject: Spinal cord injury
subject: tetraplegia
subject: upper limb reconstruction
subject: tendon transfer
subject: 610 Medical sciences; Medicine

description: Objectives/Interrogation: More than 50% of spinal cord injuries occur at the cervical level, leading to tetraplegia. Surgical restoration of upper limb function has the ability to improve patient autonomy and self-esteem [ref:1]. However, these operations are underutilised in the[for full text, please go to the a.m. URL]
description: 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT)
Scale-invariant biomarker discovery in urine and plasma metabolite fingerprints
Creators: name: Zacharias, Helena U.
name: Rehberg, Thorsten
name: Mehrl, Sebastian
name: Richtmann, Daniel
name: Wettig, Tilo
name: Oefner, Peter J.
name: Spang, Rainer
name: Gronwald, Wolfram
name: Altenbuchinger, Michael
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantitative Methods (q-bio.QM)
subject: FOS: Biological sciences

description: Motivation: Metabolomics data is typically scaled to a common reference like a constant volume of body fluid, a constant creatinine level, or a constant area under the spectrum. Such normalization of the data, however, may affect the selection of biomarkers and the biological interpretation of results in unforeseen ways. Results: First, we study how the outcome of hypothesis tests for differential metabolite concentration is affected by the choice of scale. Furthermore, we observe this interdependence also for different classification approaches. Second, to overcome this problem and establish a scale-invariant biomarker discovery algorithm, we extend linear zero-sum regression to the logistic regression framework and show in two applications to ${}^1$H NMR-based metabolomics data how this approach overcomes the scaling problem. Availability: Logistic zero-sum regression is available as an R package as well as a high-performance computing implementation that can be downloaded at https://github.com/rehbergT/zeroSum