cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
История гениальности в России: Михаил Васильевич Ломоносов (1711-2016)
Creators: name: Чернов Сергей Васильевич
Publisher: name: Философская школа
Year: 2017
Subjects: ИСТОРИЯ ГЕНИАЛЬНОСТИ
М. В. ЛОМОНОСОВ
ПЕРВОПРОХОДЕЦ-СОЗИДАТЕЛЬ
РУССКИЙ ЯЗЫК
НАУЧНАЯ ТЕРМИНОЛОГИЯ
ТВОРЧЕСКАЯ ЖИЗНЬ ГЕНИЯ
ХИМИЧЕСКАЯ ЛАБОРАТОРИЯ ЛОМОНОСОВА
ОТТЕНКИ ЦВЕТНОГО СТЕКЛА
МОЗАИЧНЫЕ КАРТИНЫ
РУССКИЙ ГЕНИЙ
HISTORY OF GENIUS
M. V. LOMONOSOV
PIONEER CREATOR
RUSSIAN LANGUAGE
SCIENTIFIC TERMINOLOGY
CREATIVE LIFE OF THE GENIUS
CHEMICAL LABORATORY OF LOMONOSOV
SHADES OF COLOR GLASS
MOSAIC PICTURES
RUSSIAN GENIUS

description: Настоящая работа составлена из нескольких фрагментов, взятых из трудов С. В. Чернова «Истории гениальности в России», первая книга этих трудов, посвящённая Михаилу Васильевичу Ломоносову, носит название «Университет всея Руси». В декабре 2016 года эта книга была подписана в печать и планируется к выходу в первом квартале 2017 года. В указанной монографии предметом исследования является гений Ломоносова, творческая жизнь которого определяет его как самобытного русского гения и как знаковую фигуру для русской культуры в целом. В отличие от множества других трудов, где исследуется творческая биография М. В. Ломоносова, указанная монография выстроена иначе. Главную задачу настоящего исследования, автор видит в том, чтобы, опираясь на факты созидательной творческой деятельности Ломоносова, раскрыть, прежде всего, феноменологию гениальности (универсальную, созидательную и духовно-нравственную составляющие человеческого гения), опираясь на уникальную во всех отношениях феноменологию гения Ломоносова, интересного прежде всего тем, что в нём очень ярко и наглядно раскрывается строение русского творческого духа, собственно то, что мы и называем русским гением. Представленная здесь работа приурочена к 305-летию со дня рождения М. В. Ломоносова.Review. This article has made of several fragments taken from S. V. Chernov's works «History of genius in Russia», the first book of these works devoted to Michael Vasil'evich Lomonosov carries the name «University of All Russia». In December, 2016 this book was sent for the press and is planned to an exit in the first quarter 2017. In the specified monograph an object of research is the genius of Lomonosov whose creative life defines it as the original Russian genius and as a sign figure for the Russian culture in general. Unlike a set of other works where the creative biography of M. V. Lomonosov is investigated, the specified monograph is built differently. The main task of this research consists in opening genius phenomenology (universal, creative and spiritual and moral making the human genius) on the basis of unique phenomenology of the genius of Lomonosov. He is interesting first of all that the structure of the Russian spirit that is the Russian genius reveals in him. The work presented here is dated for the 305 anniversary since the birth of M. V. Lomonosov.
Using $B^0_s\to D_s^\mp K^\pm$ Decays as a Portal to New Physics
Creators: name: Fleischer, Robert
name: Malami, Eleftheria
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: FOS: Physical sciences

description: The system of $B^0_s\to D_s^\mp K^\pm$ decays offers a theoretically clean determination of the angle $γ$ of the Unitarity Triangle. A corresponding LHCb analysis resulted in a surprisingly large result, which is in tension with other determinations and global analyses of the Unitarity Triangle. Paying special attention to discrete ambiguities, we confirm this picture and resolve a final ambiguity. Moreover, we extract the branching ratios of the underlying $\bar{B}^0_s\to D_s^+K^-$ and $\bar{B}^0_s\to D_s^- K^+$ modes. Combining them with information from semileptonic $B_{(s)}$ decays, we arrive at another puzzling situation, which we obtain also for other decays with similar dynamics. These patterns could be footprints of New Physics in the $b\to c \bar{u} s$ and $b \to u \bar{c} s$ processes which govern the dynamics of the $\bar{B}^0_s\to D_s^\mp K^\pm$ channels. Employing a model-independent parametrisation, we present a strategy to reveal such effects. Applying it to the present data, we obtain strongly correlated New-Physics contributions with potentially large CP-violating phases. We find that new contributions sizeably smaller than the Standard Model amplitudes could actually accommodate the current data. This strategy offers an exciting probe for new sources of CP violation at the future high-precision frontier of $B$ physics.
description: 36 pages, 5 figures, version to appear in Physical Review D
Homogenization of the Navier–Stokes equations in perforated domains in the inviscid limit
Creators: name: Höfer, Richard M.
Publisher: name: Universität Regensburg
Year: 2023
Subjects: subject: homogenization, perforated domain, Navier–Stokes equations, inviscid limit, Euler equations, Darcy’s law, Euler–Brinkman equations Mathematics Subject Classification numbers: 35Q30, 35Q31, 76D07, 76M50, 76S05,76T25
subject: 510 Mathematik

description: We study the solution uε to the Navier–Stokes equations in R3 perforated by small particles centered at (εZ)3 with no-slip boundary conditions at the particles. We study the behavior of uε for small ε, depending on the diameter εα, α>1, of the particles and the viscosity εγ, γ >0, of the fluid. We prove quantitative convergence results for uε in all regimes when the local Reynolds number at the particles is negligible. Then, the particles approximately exert a linear friction force on the fluid. The obtained effective macroscopic equations depend on the order of magnitude of the collective friction. We obtain (a) the Euler–Brinkman equations in the critical regime, (b) the Euler equations in the subcritical regime and (c) Darcy’s law in the supercritical regime.
Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis
Creators: name: Webster, Paul
name: Gukovsky, Ilya
name: O’Konski, Mark S.
name: Katunuma, Nobuhiko
name: Erickson, Ann H.
name: Gukovskaya, Anna S.
name: Mareninova, Olga A.
name: Hermann, Kip
name: Gorelick, Fred S.
name: Pandol, Stephen J.
name: French, Samuel W.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The pathogenic mechanisms underlying acute pancreatitis are not clear. Two key pathologic acinar cell responses of this disease are vacuole accumulation and trypsinogen activation. We show here that both result from defective autophagy, by comparing the autophagic responses in rodent models of acute pancreatitis to physiologic autophagy triggered by fasting. Pancreatitis-induced vacuoles in acinar cells were greater in number and much larger than those induced with fasting. Degradation of long-lived proteins, a measure of autophagic efficiency, was markedly inhibited in in vitro pancreatitis, while it was stimulated by acinar cell starvation. Further, processing of the lysosomal proteases cathepsin L (CatL) and CatB into their fully active, mature forms was reduced in pancreatitis, as were their activities in the lysosome-enriched subcellular fraction. These findings indicate that autophagy is retarded in pancreatitis due to deficient lysosomal degradation caused by impaired cathepsin processing. Trypsinogen activation occurred in pancreatitis but not with fasting and was prevented by inhibiting autophagy. A marker of trypsinogen activation partially localized to autophagic vacuoles, and pharmacologic inhibition of CatL increased the amount of active trypsin in acinar cells. The results suggest that retarded autophagy is associated with an imbalance between CatL, which degrades trypsinogen and trypsin, and CatB, which converts trypsinogen into trypsin, resulting in intra-acinar accumulation of active trypsin in pancreatitis. Thus, deficient lysosomal degradation may be a dominant mechanism for increased intra-acinar trypsin in pancreatitis.
Бесприютная флейта: о поэзии Арсения Тарковского
Creators: name: Пекелис Михаил Абрамович
Publisher: name: Философская школа
Year: 2017
Subjects: ПОЭЗИЯ
АРСЕНИЙ ТАРКОВСКИЙ
ТВОРЧЕСКИЙ ПУТЬ
ВОЕННАЯ ЛИРИКА
ФИЛОСОФСКАЯ ЛИРИКА
ЛЮБОВНАЯ ЛИРИКА
ЧЕЛОВЕК
ТВОРЕЦ
ВЕЧНАЯ ЖИЗНЬ
МИФОЛОГИЯ
POETRY
ARSENY TARKOVSKY
CAREER
MILITARY LYRICS
PHILOSOPHICAL LYRICS
LOVE LYRICS
PERSON
CREATOR
ETERNAL LIFE
MYTHOLOGY

description: В 1983 году вышла в свет книга стихов Арсения Тарковского «Стихи разных лет». Фактически это была книга избранного. Первоначально данная статья предназначалась журналу «Юность», но было решено для журнала «Юность» заказать статью более маститому критику, а эту статью напечатать в журнале «Литературное обозрение». Завершилось всё тем, что статья не прошла цензуру. Полагаю, что это решение «Главлита» было продиктовано не отношением к автору статьи, не содержанием самой статьи и даже не попыткой замалчивания поэта. Вмешался Его Величество Случай. Совпали два события: смерть Леонида Ильича Брежнева и переход в финальную, драматическую стадию трёхлетнего, своевольного проживания Андрея Тарковского (сына поэта) в Италии. Статья болталась по столам цензоров до лета 1984 года и, когда Андрей Тарковский принял твёрдое решение остаться в Италии, была окончательно похоронена советской цензурой. Это не помешало автору подарить статью Арсению Тарковскому. Статья ему понравилась, и он подарил мне на память свою книгу с очень доброй и теплой надписью. Так что эта статья выходит впервые, через 33 года после её написания.Review. In 1983 the book of verses of Arseny Tarkovsky «Verses of different years» was published. Actually it was the book of the electee. Originally this article intended to the Yunost magazine, but was decided to order for the Yunost magazine article to more venerable critic, and to print this article in the Literary Review magazine. Everything came to the end with the fact that article did not pass censorship. I believe that this decision of Glavlit was dictated not by the attitude towards the author of article, not contents of the article and even not attempt of concealment of the poet. Its Majesty Case had intervened. Two events coincided: Leonid Brezhnev's death and transition to a final, drama stage of three years', willful residence of Andrey Tarkovsky (son of the poet) in Italy. Article dangled on tables of censors till summer of 1984 and when Andrey Tarkovsky made the firm decision to remain in Italy, was finally buried by the Soviet censorship. It did not prevent the author to present article to Arseny Tarkovsky. Article was pleasant to it, and he gave to me as keepsake the book with very kind and warm inscription. So this article appears for the first time, in 33 years after its writing.
Holographic energy density, dark energy sound speed, and tensions in cosmological parameters: $H_0$ and $S_8$
Creators: name: Cardona, Wilmar
name: Sabogal, M. A.
Publisher: name: arXiv
Year: 2022
Subjects: subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: FOS: Physical sciences

description: Interesting discrepancies in cosmological parameters are challenging the success of the $Λ$CDM model. Direct measurements of the Hubble constant $H_0$ using Cepheid variables and supernovae turn out to be higher than inferred from the Cosmic Microwave Background (CMB). Weak galaxy lensing surveys consistently report values of the strength of matter clustering $σ_8$ lower than values derived from the CMB in the context of $Λ$CDM. In this paper we address these discrepancies in cosmological parameters by considering Dark Energy (DE) as a fluid with evolving equation of state $w_{\mathrm{de}}(z)$, constant sound speed squared $\hat{c}_{\mathrm{s}}^{2}$, and vanishing anisotropic stress $σ$. Our $w_{\mathrm{de}}(z)$ is derived from the Holographic Principle and can consecutively exhibit radiation-like, matter-like, and DE-like behaviour, thus affecting the sound horizon and the comoving angular diameter distance, hence $H_0$. Here we show DE sound speed plays a part in the matter clustering behaviour through its effect on the evolution of the gravitational potential. We compute cosmological constraints using several data set combinations including primary CMB, CMB lensing, redshift-space-distortions, local distance-ladder, supernovae, and baryon acoustic oscillations. In our analysis we marginalise over $\hat{c}_{\mathrm{s}}^{2}$ and find $\hat{c}_{\mathrm{s}}^{2}=1$ is excluded at $\gtrsim 3σ$. For our baseline result including the whole data set we found $H_0$ and $σ_8$ in good agreement (within $\approx 2σ$) with low redshift probes. Our constraint for the baryon energy density $ω_{\rm{b}}$ is however in $\approx 3σ$ tension with BBN constraints. We conclude evolving DE also having non-standard clustering properties [e.g., $\hat{c}_{\mathrm{s}}^{2}(z,k)$] might be relevant for the solution of current discrepancies in cosmological parameters.
description: 28 pages, 12 figures, 3 tables. References added. Published version
$\mathcal{L}_1$ Adaptive Augmentation for Geometric Tracking Control of Quadrotors
Creators: name: Wu, Zhuohuan
name: Cheng, Sheng
name: Ackerman, Kasey A.
name: Gahlawat, Aditya
name: Lakshmanan, Arun
name: Zhao, Pan
name: Hovakimyan, Naira
Publisher: name: arXiv
Year: 2021
Subjects: subject: Systems and Control (eess.SY)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: This paper introduces an $\mathcal{L}_1$ adaptive control augmentation for geometric tracking control of quadrotors. In the proposed design, the $\mathcal{L}_1$ augmentation handles nonlinear (time- and state-dependent) uncertainties in the quadrotor dynamics without assuming or enforcing parametric structures, while the baseline geometric controller achieves stabilization of the known nonlinear model of the system dynamics. The $\mathcal{L}_1$ augmentation applies to both the rotational and the translational dynamics. Experimental results demonstrate that the augmented geometric controller shows consistent and (on average five times) smaller trajectory tracking errors compared with the geometric controller alone when tested for different trajectories and under various types of uncertainties/disturbances.
description: accepted by ICRA 2022
MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice
Creators: name: Tang, Ru-Hang
name: Willis, Monte S.
name: Shumate, Janelle
name: Tatsuguchi, Mariko
name: Seok, Hee Young
name: Selzman, Craig H.
name: Deng, Zhongliang
name: Wang, Da-Zhi
name: Callis, Thomas E.
name: Pandya, Kumar
name: Chen, Jian-Fu
name: Huang, Zhan-Peng
name: Gunn, Bronwyn
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: MicroRNAs (miRNAs) are a class of small noncoding RNAs that have gained status as important regulators of gene expression. Here, we investigated the function and molecular mechanisms of the miR-208 family of miRNAs in adult mouse heart physiology. We found that miR-208a, which is encoded within an intron of α-cardiac muscle myosin heavy chain gene (Myh6), was actually a member of a miRNA family that also included miR-208b, which was determined to be encoded within an intron of β-cardiac muscle myosin heavy chain gene (Myh7). These miRNAs were differentially expressed in the mouse heart, paralleling the expression of their host genes. Transgenic overexpression of miR-208a in the heart was sufficient to induce hypertrophic growth in mice, which resulted in pronounced repression of the miR-208 regulatory targets thyroid hormone–associated protein 1 and myostatin, 2 negative regulators of muscle growth and hypertrophy. Studies of the miR-208a Tg mice indicated that miR-208a expression was sufficient to induce arrhythmias. Furthermore, analysis of mice lacking miR-208a indicated that miR-208a was required for proper cardiac conduction and expression of the cardiac transcription factors homeodomain-only protein and GATA4 and the gap junction protein connexin 40. Together, our studies uncover what we believe are novel miRNA-dependent mechanisms that modulate cardiac hypertrophy and electrical conduction.
Я ваш поэт. Вл. Маяковский
Creators: name: Лемешева Юлия Витальевна
Publisher: name: Философская школа
Year: 2017
Subjects: ПОЭЗИЯ
ВЛАДИМИР МАЯКОВСКИЙ
ТВОРЧЕСТВО
ФУТУРИЗМ
АЛЛЮЗИЯ
АЛЛИТЕРАЦИЯ
ЖИЗНЬ
ОДИНОЧЕСТВО
ЛЮБОВИЩЕ
ГЕНИАЛЬНЫЙ ЛИРИК
POETRY
VLADIMIR MAYAKOVSKY
CREATIVITY
FUTURISM
HINT
ALLITERATION
LIFE
LONELINESS
LOVE
INGENIOUS LYRIC POET

description: В статье рассматриваются некоторые факты творческой биографии В. Маяковского. Особое внимание уделено его повальной, угловатой, беззащитной любовище. Она была больше его, и это удивительное и жуткое чувство, взрывающее все его стихи изнутри, вызывает особый интерес в судьбе поэта.Review. The article describes some facts of the creative biography of V. Mayakovsky. Special attention is paid to his general, angular, defenseless love. It was more him, both surprising and terrible feeling which is blowing up all its verses from within attracts particular interest in destiny of the poet.
Grass-roots optimization of coupled oscillator networks
Creators: name: Chamlagai, Pranick R.
name: Taylor, Dane
name: Skardal, Per Sebastian
Publisher: name: arXiv
Year: 2021
Subjects: subject: Adaptation and Self-Organizing Systems (nlin.AO)
subject: FOS: Physical sciences

description: Despite the prevalence of biological and physical systems for which synchronization is critical, existing theory for optimizing synchrony depends on global information and does not sufficiently explore local mechanisms that enhance synchronization. Thus, there is a lack of understanding for the self-organized, collective processes that aim to optimize/repair synchronous systems, e.g., the dynamics of paracrine signaling within cardiac cells. Here we present ``grass-roots'' optimization of synchronization, which is a multiscale mechanism in which local optimizations of smaller subsystems cooperate to collectively optimize an entire system. Considering models of cardiac tissue and a power grid, we show that grass-roots-optimized systems are comparable to globally optimized systems, but they also have the added benefit of being robust to targeted attacks or subsystem islanding. Our findings motivate and support further investigation into the physics of local mechanisms that can support self-optimization for complex systems.
Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice
Creators: name: Blanton, Robert
name: Mendelsohn, Michael E.
name: Bedja, Djahida
name: Takimoto, Eiki
name: Nagayama, Takahiro
name: Kass, David A.
name: Siderovski, David P.
name: Hsu, Steven
name: Zhang, Manling
name: Ketner, Elizabeth A.
name: Gabrielson, Kathleen L.
name: Koitabashi, Norimichi
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: The heart initially compensates for hypertension-mediated pressure overload by enhancing its contractile force and developing hypertrophy without dilation. Gq protein–coupled receptor pathways become activated and can depress function, leading to cardiac failure. Initial adaptation mechanisms to reduce cardiac damage during such stimulation remain largely unknown. Here we have shown that this initial adaptation requires regulator of G protein signaling 2 (RGS2). Mice lacking RGS2 had a normal basal cardiac phenotype, yet responded rapidly to pressure overload, with increased myocardial Gq signaling, marked cardiac hypertrophy and failure, and early mortality. Swimming exercise, which is not accompanied by Gq activation, induced a normal cardiac response, while Rgs2 deletion in Gαq-overexpressing hearts exacerbated hypertrophy and dilation. In vascular smooth muscle, RGS2 is activated by cGMP-dependent protein kinase (PKG), suppressing Gq-stimulated vascular contraction. In normal mice, but not Rgs2–/– mice, PKG activation by the chronic inhibition of cGMP-selective phosphodiesterase 5 (PDE5) suppressed maladaptive cardiac hypertrophy, inhibiting Gq-coupled stimuli. Importantly, PKG was similarly activated by PDE5 inhibition in myocardium from both genotypes, but PKG plasma membrane translocation was more transient in Rgs2–/– myocytes than in controls and was unaffected by PDE5 inhibition. Thus, RGS2 is required for early myocardial compensation to pressure overload and mediates the initial antihypertrophic and cardioprotective effects of PDE5 inhibitors.
Optimizing Wi-Fi Channel Selection in a Dense Neighborhood
Creators: name: Vaizman, Yonatan
name: Wang, Hongcheng
Publisher: name: arXiv
Year: 2022
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: Signal Processing (eess.SP)
subject: FOS: Computer and information sciences
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: In dense neighborhoods, there are often dozens of homes in close proximity. This can either be a tight city-block with many single-family homes (SFHs), or a multiple dwelling units (MDU) complex (such as a big apartment building or condominium). Each home in such a neighborhood (either a SFH or a single unit in a MDU complex) has its own Wi-Fi access point (AP). Because there are few (typically 2 or 3) non-overlapping radio channels for Wi-Fi, neighboring homes may find themselves sharing a channel and competing over airtime, which may cause bad experience of slow internet (long latency, buffering while streaming movies, etc.). Wi-Fi optimization over all the APs in a dense neighborhood is highly desired to provide the best user experience. We present a method for Wi-Fi channel selection in a centralized way for all the APs in a dense neighborhood. We describe how to use recent observations to estimate the potential-pain matrix - for each pair of APs, how much Wi-Fi-pain would they cause each other if they were on the same channel. We formulate an optimization problem - finding a channel allocation (which channel each home should use) that minimizes the total Wi-Fi-pain in the neighborhood. We design an optimization algorithm that uses gradient descent over a neural network to solve the optimization problem. We describe initial results from offline experiments comparing our optimization solver to an off-the-shelf mixed-integer-programming solver. In our experiments we show that the off-the-shelf solver manages to find a better (lower total pain) solution on the train data (from the recent days), but our neural-network solver generalizes better - it finds a solution that achieves lower total pain for the test data (tomorrow).
description: We discussed this work in the 2022 Fall Technical Forum as part of SCTE Cable-Tec Expo. This paper was published in SCTE Technical Journal. For citing this work, please cite the original publication
Герменевтика текстов берлинского затворника русской литературы Вадима Фадина
Creators: name: Пекелис Михаил Абрамович
name: Антипов Сергей Сергеевич
Publisher: name: Философская школа
Year: 2017
Subjects: ЧЕЛОВЕК
РОССИЯ
ГЕРМАНИЯ
БЕРЛИН
ЛИТЕРАТУРА
ЭМИГРАЦИЯ
ВАДИМ ФАДИН
ГЕРМЕНЕВТИКА
ЭКЗИСТЕНЦИЯ
АРМАГЕДДОН

description: История русской цивилизации насчитывает несколько глубочайших социальных катаклизмов и гуманитарных катастроф, следствием которых становились многомиллионные эмиграционные потоки. При этом эмигрантская среда зачастую выдвигала выдающихся деятелей русской культуры и литературы, которые вносили неоценимый вклад в сокровищницу русской мысли, оставаясь при этом в поле чужеродной им иностранной культуры. В данной статье исследуются тексты, жизнь и творчество русского писателя Вадима Ивановича Фадина, который в 1996 году эмигрировал в Германию и по настоящее время проживает в Берлине. В качестве философского метода исследования используется герменевтика, а в качестве философского жанра «письма к другу». Показаны некоторые закономерности и законы преемственности в организации социальной жизни русской литературы за рубежом.
Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium
Creators: name: Yang, Yanan
name: Yu, Ming
name: Kurie, Jonathan M.
name: Lee, Daekee
name: Pannicia, Christina
name: Kim, Kyoungmi
name: Threadgill, David W.
name: Kim, Hyunok
name: Lee, Eunjung
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2009

description: Pharmacologic blockade of EGFR or the closely related receptor ERBB2 has modest efficacy against colorectal cancers in the clinic. Although the upregulation of ERBB3, a pseudo-kinase member of the EGFR/ERBB family, is known to contribute to EGFR inhibitor resistance in other cancers, its functions in normal and malignant intestinal epithelium have not been defined. We have shown here that the intestinal epithelium of mice with intestine-specific genetic ablation of Erbb3 exhibits no cytological abnormalities but does exhibit loss of expression of ERBB4 and sensitivity to intestinal damage. By contrast, intestine-specific Erbb3 ablation resulted in almost complete absence of intestinal tumors in the ApcMin mouse model of colon cancer. Unlike nontransformed epithelium lacking ERBB3, intestinal tumors lacking ERBB3 had reduced PI3K/AKT signaling, which led to attenuation of tumorigenesis via a tumor-specific increase in caspase-3–mediated apoptosis. Consistent with the mouse data, which suggest that ERBB3-ERBB4 heterodimers contribute to colon cancer survival, experimentally induced loss of ERBB3 in a KRAS mutant human colon cancer cell line was associated with loss of ERBB4 expression, and siRNA knockdown of either ERBB3 or ERBB4 resulted in elevated levels of apoptosis. These results indicate that the ERBB3 pseudo-kinase has essential roles in supporting intestinal tumorigenesis and suggest that ERBB3 may be a promising target for the treatment of colorectal cancers.
Противостояние цивилизаций
Creators: name: Спирова Эльвира Маратовна
Publisher: name: Философская школа
Year: 2017
Subjects: КУЛЬТУРА
ЦИВИЛИЗАЦИЯ
ВАРВАРСТВО
ЕВРОПОЦЕНТРИЗМ
ГЛОБАЛИЗАЦИЯ
КУЛЬТУРНАЯ АНТРОПОЛОГИЯ
КУЛЬТУРНО-ИСТОРИЧЕСКИЕ ТИПЫ
ДУХОВНОСТЬ
ЦЕННОСТИ
КОНФЛИКТ ЦИВИЛИЗАЦИЙ
ПАССИОНАРНОСТЬ

description: В статье анализируется современная геополитическая ситуация. Отмечается, что в нынешнюю эпоху стержнем противостояний выступает не нация, не государство, а цивилизация. Разумеется, эта тема давно обсуждается в социальной философии, однако она получила в наши дни особую остроту. Прежде всего, многое изменилось в самом содержательном толковании понятия «цивилизация». Многие стороны социальной жизни в былые времена, по мнению современных исследователей, были организованы гораздо целесообразнее и даже цивилизованнее, чем в современном социуме. В практике древних обществ обнаружены ценные идеи и достижения, которые в значительной мере наносят удар европоцентризму. Встреча цивилизаций стирает особенности разных культур. Неслучайно многие исследователи, представляя локальные культуры, говорят именно об особом укладе жизни и необычном духовном опыте. Среди претендентов на мировое господство остаётся, судя по всему, евроатлантическая цивилизация. Но это вовсе не означает, что евроатлантическая цивилизация имеет все шансы на универсальность.
Effective two-body approach to the hierarchical three-body problem: quadrupole to 1PN
Creators: name: Kuntz, Adrien
name: Serra, Francesco
name: Trincherini, Enrico
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Relativity and Quantum Cosmology (gr-qc)
subject: Earth and Planetary Astrophysics (astro-ph.EP)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Solar and Stellar Astrophysics (astro-ph.SR)
subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: Many binary systems of interest for gravitational-wave astronomy are orbited by a third distant body, which can considerably alter their relativistic dynamics. Precision computations are needed to understand the interplay between relativistic corrections and three-body interactions. We use an effective field theory approach to derive the effective action describing the long time-scale dynamics of hierarchical three-body systems up to 1PN quadrupole order. At this level of approximation, computations are complicated by the backreaction of small oscillations on orbital time-scales as well as deviations from the adiabatic approximation. We address these difficulties by eliminating the fast modes through the method of near-identity transformations. This allows us to compute for the first time the complete expression of the 1PN quadrupole cross-terms in generic configurations of three-body systems. We numerically integrate the resulting equations of motion and show that 1PN quadrupole terms can affect the long term dynamics of relativistic three-body systems.
description: 41 pages, 3 figures
Heavy-meson chiral Lagrangians, effective flavored couplings, SU(4) flavor breaking and their consequences
Creators: name: El-Bennich, Bruno
name: Serna, Fernando E.
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: High Energy Physics - Experiment (hep-ex)
subject: High Energy Physics - Lattice (hep-lat)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We review heavy quark flavor and spin symmetries, their exploitation in heavy meson effective theories and the flavored couplings of charmed and light mesons in the definition of their effective Lagrangians. We point out how nonperturbative continuum QCD approaches based on Dyson-Schwinger and Bethe-Salpeter equations can be used to calculate strong and leptonic decays of open-charm mesons and heavy quarkonia. The strong decay $D^*\to Dπ$ serves as a benchmark, as it is the only physical open-charm observable that can be related to the effective Lagrangian's couplings. Nonetheless, a quantitative comparison of $D^*Dπ$, $ρDD$, $ρD^*D$ and $ρD^* D^*$ couplings for a range of off-shell momenta of the $ρ$-meson invalidates SU(4)$_F$ symmetry relations between these couplings. Thus, besides the breaking of flavor symmetry by mass terms in the Lagrangians, the flavor-symmetry breaching in couplings and their dependence on the $ρ$-meson virtuality cannot be ignored. We also take the opportunity to present new results for the effective $J/ψDD$ and $J/ψD^*D$ couplings. We conclude this contribution with a discussion on how the description of pseudoscalar and vector $D$, $D_s$, $B$ and $B_s$ meson properties can be drastically improved with a modest modification of the flavor-dependence in the Bethe-Salpeter equation.
description: Contribution to the proceedings of the 10th International Workshop on Charm Physics (CHARM 2020), 26 pages, 4 tables, 5 figures. Additional references, typo in tensor basis of vector mesons corrected. Published in PoS
X-ray spectral variability of LINERs selected from the Palomar sample
Creators: name: Hernández-García, L.
name: González-Martín, O.
name: Masegosa, J.
name: Márquez, I.
Publisher: name: arXiv
Year: 2014
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: Astrophysics of Galaxies (astro-ph.GA)
subject: FOS: Physical sciences

description: Variability is a general property of active galactic nuclei (AGN). At X-rays, the way in which these changes occur is not yet clear. In the particular case of low ionisation nuclear emission line region (LINER) nuclei, variations on months/years timescales have been found for some objects, but the main driver of these changes is still an open question. The main purpose of this work is to investigate the X-ray variability in LINERs, including the main driver of such variations, and to search for eventual differences between type 1 and 2 objects. We use the 18 LINERs in the Palomar sample with data retrieved from Chandra and/or XMM-Newton archives corresponding to observations gathered at different epochs. All the spectra for the same object are simultaneously fitted in order to study long term variations. The nature of the variability patterns are studied allowing different parameters to vary during the spectral fit. Whenever possible, short term variations from the analysis of the light curves and UV variability are studied.
description: 49 pages, accepted. arXiv admin note: text overlap with arXiv:1305.2225
Этноантропологическая концепция Ж. -Ж. Руссо
Creators: name: Шажинбат Ариунаа
Publisher: name: Философская школа
Year: 2017
Subjects: ФИЛОСОФИЯ
КУЛЬТУРА
ИДЕНТИЧНОСТЬ
ЭТНОС
ЧЕЛОВЕК
ЭТНОГРАФИЯ
ЭТНОАНТРОПОЛОГИЯ
ЕВРОПОЦЕНТРИЗМ
РАЗЛИЧИЕ
РАЦИОНАЛИЗМ

description: В статье анализируется этноантропологическая концепция Ж.-Ж. Руссо. Автор отмечает, что этот мыслитель имеет своеобразную концепцию, которая относится к феноменологии этноса. Его взгляд на эту тему отличается от европоцентристской установки просветительского сознания XVIII в. Опираясь на работы этнографов, Руссо радикально переосмысливает понятие самотождественности человека. Французский мыслитель дистанцируется от концепции Декарта, которая усматривает самопостижение личности во внутренней работе «я». Руссо полагает, что представление человека о самом себе, так же как и этноса о своей сущности, невозможны без оглядки на другого человека или этнического образования. В контексте такого сравнения само понятие «я» значительно сужается, поскольку, принимая на себя образ другого, человек, в той же мере и как этнос, осознает относительность своих представлений. Расшифровка другого приводит к тому, что человек пытается увидеть себя в зеркале иного существа или иной культуры. Именно поэтому К. Леви-Стросс назвал Руссо основателем гуманитарных наук. Представление о сложностях самоопознавания своей и чужой культуры, изложенная Руссо, получила развитие в постмодернистской философии.
OPENING GATES TO OPEN SCIENCE: IMPACT OF DIGITAL TECHNOLOGIES IN FOSTERING OPEN SCIENCE PRINCIPLES IN RESEARCH
Creators: name: Simon, Kiplangat Bett
name: Dr. Elisha, Ondieki Makori
Publisher: name: ZAP Journal
Year: 2024
Subjects: Open Access, Digital Technologies, Digital Repositories, Artificial Intelligence, Open Access Journals, Pre-print Servers, Open Educational Resources

description: This comprehensive systematic review investigates the instrumental impact of digital technologies on advancing the foundational principles of Open Science. The primary objective is to conduct a thorough examination of the intricate impacts of technology on enhancing accessibility, transparency, and collaboration within the scientific community. Specifically, it provides a comprehensive overview of the symbiotic relationship between digital technologies and Open Science principles. Drawing upon a diverse array of literature, including studies, articles, and reports from various disciplines, this review explores key themes integral to the paradigm shift toward Open Science. Central to the analysis are the democratization of knowledge facilitated by open access repositories, the transformative capabilities inherent in data-sharing platforms and the collaborative opportunities presented by digital tools in the dissemination of research. This review also explores the challenges and ethical considerations arising from the integration of digital technologies into the scientific process. Through the synthesis of current research, this review aims to provide a comprehensive understanding of how digital technologies have actively contributed to the evolution of Open Science. This elucidates crucial insights for researchers, policymakers, and practitioners eager to harness the complete potential of technology to cultivate a more open and collaborative scientific landscape. By delving into the nuanced interplay between digital tools and Open Science principles, this review offers a valuable resource that not only identifies current trends but also shapes future directions in the dynamic intersection of technology and scientific inquiry. Results suggest that open science practices require interdisciplinary planning and that methodologies, sampling, data collection tools, and online dissemination techniques are suitable for digital platforms
Finite-temperature effects on D-meson properties
Creators: name: Torres-Rincon, Juan M.
name: Montaña, Glòria
name: Ramos, Àngels
name: Tolos, Laura
Publisher: name: arXiv
Year: 2021
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Nuclear Theory (nucl-th)
subject: FOS: Physical sciences

description: We study the spectroscopy and transport properties of charmed mesons in a thermal medium by applying an effective field theory based on chiral and heavy-quark symmetries in the imaginary time formalism. Relying on unitarity constraints and self-consistency we extract the in-medium properties (masses and widths) of $D$ and $D_s$ mesons and their interactions with light hadrons. We report our findings on 1) dynamically generated states, 2) thermal evolution of chiral partners, 3) in-medium scattering amplitudes, and 4) transport coefficients below the chiral restoration temperature.
description: 11 pages, 7 figures. Contribution to the 10th International Workshop on Charm Physics (CHARM2020). Accepted for publication in Proceedings of Science
Концепция В. И. Вернадского о живом веществе как созидательной силе
Creators: name: Черняго Любовь Сергеевна
Publisher: name: Философская школа
Year: 2017
Subjects: В. И. ВЕРНАДСКИЙ
БИОСФЕРА
ЖИВОЕ ВЕЩЕСТВО
ЖИЗНЬ
БИОГЕННАЯ МИГРАЦИЯ АТОМОВ
БИОЛОГИЧЕСКАЯ АРХИТЕКТОНИКА
ЛЕСА
БИОТИЧЕСКИЙ НАСОС
ДЕСТАБИЛИЗАЦИЯ КЛИМАТА

description: В статье рассмотрена концепция живого вещества, разработанная академиком В. И. Вернадским в контексте ее дальнейшего развития. Особое внимание уделено «механизму» биосферы, основанному на бике биогенном круговороте атомов. Отмечена огромная роль лесов в трансформации солнечной энергии и поддержании глобального круговорота воды.
Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon
Creators: name: Yu, Kuai
name: Lujan, Rafael
name: Gabriel, Sherif
name: Hartzell, H. Criss
name: Marmorstein, Alan
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Anion transport by the colonic mucosa maintains the hydration and pH of the colonic lumen, and its disruption causes a variety of diarrheal diseases. Cholinergic agonists raise cytosolic Ca2+ levels and stimulate anion secretion, but the mechanisms underlying this effect remain unclear. Cholinergic stimulation of anion secretion may occur via activation of Ca2+-activated Cl– channels (CaCCs) or an increase in the Cl– driving force through CFTR after activation of Ca2+-dependent K+ channels. Here we investigated the role of a candidate CaCC protein, bestrophin-2 (Best2), using Best2–/– mice. Cholinergic stimulation of anion current was greatly reduced in Best2–/– mice, consistent with our proposed role for Best2 as a CaCC. However, immunostaining revealed Best2 localized to the basolateral membrane of mucin-secreting colonic goblet cells, not the apical membrane of Cl–-secreting enterocytes. In addition, in the absence of HCO3–, cholinergic-activated current was identical in control and Best2–/– tissue preparations, which suggests that most of the Best2 current was carried by HCO3–. These data delineate an alternative model of cholinergic regulation of colonic anion secretion in which goblet cells play a critical role in HCO3– homeostasis. We therefore propose that Best2 is a HCO3– channel that works in concert with a Cl:HCO3– exchanger in the apical membrane to affect transcellular HCO3– transport. Furthermore, previous models implicating CFTR in cholinergic Cl– secretion may be explained by substantial downregulation of Best2 in Cftr–/– mice.
Fast Stabiliser Simulation with Quadratic Form Expansions
Creators: name: de Beaudrap, Niel
name: Herbert, Steven
Publisher: name: arXiv
Year: 2021
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: This paper builds on the idea of simulating stabiliser circuits through transformations of quadratic form expansions. This is a representation of a quantum state which specifies a formula for the expansion in the standard basis, describing real and imaginary relative phases using a degree-2 polynomial over the integers. We show how, with deft management of the quadratic form expansion representation, we may simulate individual stabiliser operations in $O(n^2)$ time matching the overall complexity of other simulation techniques [arXiv:quant-ph/0406196, arXiv:quant-ph/0504117, arXiv:1808.00128]. Our techniques provide economies of scale in the time to simulate simultaneous measurements of all (or nearly all) qubits in the standard basis. Our techniques also allow single-qubit measurements with deterministic outcomes to be simulated in constant time. We also describe throughout how these bounds may be tightened when the expansion of the state in the standard basis has relatively few terms (has low 'rank'), or can be specified by sparse matrices. Specifically, this allows us to simulate a 'local' stabiliser syndrome measurement in time $O(n)$, for a stabiliser code subject to Pauli noise -- matching what is possible using techniques developed by Gidney [arXiv:2103.02202] without the need to store which operations have thus far been simulated.
description: 51 pages; only change are reference format (for Quantum journal)
[Halle (Saale), Universitäts- und Landesbibliothek Sachsen-Anhalt, Morbio 6 (59)]
Creators: name: De Aduocatis, Georgia
Publisher: name: Universitäts- und Landesbibliothek Sachsen-Anhalt
Year: 1423
Subjects: subject: Sonstige weltliche Aussteller
subject: Notarsurkunde
subject: Urkunde
subject: 090

description: Georgia de Aduocatis, Tochter des verstorbenen Christoforus und Witwe des Arondinus Bruxatus, bestätigt dem Notar Guillielmus Bruxatus, Sohn des Johannes Bruxatus de Nibia, nach Vorlage eines von diesem verfassten Dokuments vom 7. Mai 1423 die Richtigkeit und die Verlängerung desselben.
Digital Transformation of Nature Tourism
Creators: name: Luna, Raul Enrique Rodriguez
name: Martinez, Jose Luis Rosenstiehl
Publisher: name: arXiv
Year: 2022
Subjects: subject: General Economics (econ.GN)
subject: FOS: Economics and business

description: The purpose of this article is to explore the digital behavior of nature tourism SMEs in the department of Magdalena-Colombia, hereinafter referred to as the region. In this sense, the concept of endogenization as an evolutionary mechanism refers to the application of the discrete choice model as an engine of analysis for the variables to be studied within the model. The type of study was quantitative, of correlational level, the sample was 386 agents of the tourism chain; a survey-type instrument with five factors and a Likert-type scale was used for data collection. For the extraction of the factors, a confirmatory factor analysis was used, using structural equations, followed by a discrete choice model and then the analysis of the results. Among the main findings are that the SMEs in the tourism chain that tried to incorporate Big Data activities in the decision-making processes, have greater chances of success in the digital transformation, in addition, statistical evidence was found that the training of staff in Data Science, contributes significantly to the marketing and commercialization processes within the SME in this region.
description: 7 pages
Chronic administration of membrane sealant prevents severe cardiac injury and ventricular dilatation in dystrophic dogs
Creators: name: Davis, Jennifer
name: Kornegay, Joe N.
name: Turner, Immanuel
name: Martindale, Joshua
name: Shillingford, Michael
name: Yasuda, Soichiro
name: Townsend, DeWayne
name: Metzger, Joseph M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Duchenne muscular dystrophy (DMD) is a fatal disease of striated muscle deterioration caused by lack of the cytoskeletal protein dystrophin. Dystrophin deficiency causes muscle membrane instability, skeletal muscle wasting, cardiomyopathy, and heart failure. Advances in palliative respiratory care have increased the incidence of heart disease in DMD patients, for which there is no cure or effective therapy. Here we have shown that chronic infusion of membrane-sealing poloxamer to severely affected dystrophic dogs reduced myocardial fibrosis, blocked increased serum cardiac troponin I (cTnI) and brain type natriuretic peptide (BNP), and fully prevented left-ventricular remodeling. Mechanistically, we observed a markedly greater primary defect of reduced cell compliance in dystrophic canine myocytes than in the mildly affected mdx mouse myocytes, and this was associated with a lack of utrophin upregulation in the dystrophic canine cardiac myocytes. Interestingly, after chronic poloxamer treatment, the poor compliance of isolated canine myocytes remained evident, but this could be restored to normal upon direct application of poloxamer. Collectively, these findings indicate that dystrophin and utrophin are critical to membrane stability–dependent cardiac myocyte mechanical compliance and that poloxamer confers a highly effective membrane-stabilizing chemical surrogate in dystrophin/utrophin deficiency. We propose that membrane sealant therapy is a potential treatment modality for DMD heart disease and possibly other disorders with membrane defect etiologies.
Iterative tailoring of optical quantum states with homodyne measurements
Creators: name: Etesse, Jean
name: Kanseri, Bhaskar
name: Tualle-Brouri, Rosa
Publisher: name: arXiv
Year: 2014
Subjects: subject: Optics (physics.optics)
subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: As they can travel long distances, free space optical quantum states are good candidates for carrying information in quantum information technology protocols. These states, however, are often complex to produce and require protocols whose success probability drops quickly with an increase of the mean photon number. Here we propose a new protocol for the generation and growth of arbitrary states, based on one by one coherent adjunctions of the simple state superposition $α| 0 > +β| 1 >$. Due to the nature of the protocol, that allows for the use of quantum memories, it can outperform existing protocols.
Epigenetic basis for aberrant upregulation of autoantigen genes in humans with ANCA vasculitis
Creators: name: Pendergraft, William F.
name: Hewins, Peter
name: Ciavatta, Dominic J.
name: Falk, Ronald J.
name: Badhwar, Anshul K.
name: Preston, Gloria A.
name: Yang, JiaJin
name: Xiao, Hong
name: Magnuson, Terry R.
name: Jennette, J. Charles
name: Nester, Carla M.
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2010

description: Antineutrophil cytoplasmic autoantibody (ANCA) causes vascular injury that leads to small-vessel vasculitis. Patients with ANCA aberrantly express neutrophil granule–encoding genes, including 2 that encode autoantigens: proteinase 3 (PR3) and myeloperoxidase (MPO). To uncover a potential transcriptional regulatory mechanism for PR3 and MPO disrupted in patients with ANCA vasculitis, we examined the PR3 and MPO loci in neutrophils from ANCA patients and healthy control individuals for epigenetic modifications associated with gene silencing. We found that levels of the chromatin modification H3K27me3, which is associated with gene silencing, were depleted at PR3 and MPO loci in ANCA patients compared with healthy controls. Interestingly, in both patients and controls, DNA was unmethylated at a CpG island in PR3, whereas in healthy controls, DNA was methylated at a CpG island in MPO. Consistent with decreased levels of H3K27me3, JMJD3, the demethylase specific for H3K27me3, was preferentially expressed in ANCA patients versus healthy controls. In addition, we describe a mechanism for recruiting the H3K27 methyltransferase enhancer of zeste homolog 2 (EZH2) to PR3 and MPO loci mediated by RUNX3. RUNX3 message was decreased in patients compared with healthy controls, and may also be under epigenetic control. DNA methylation was increased at the RUNX3 promoter in ANCA patients. These data indicate that epigenetic modifications associated with gene silencing are perturbed at ANCA autoantigen–encoding genes, potentially contributing to inappropriate expression of PR3 and MPO in ANCA patients.