cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
Seepicola Rice, Tovar-Hernandez, Ellison & Young 2025, gen. nov.
Creators: name: Rice, Lauren N.
name: Tovar-Hernández, María Ana
name: Ellison, Christina I.
name: Young, Craig M.
Publisher: name: Zenodo
Year: 2025
Subjects: Biodiversity
Taxonomy
Animalia
Annelida
Polychaeta
Sabellida
Sabellidae
Seepicola

description: Seepicola Rice, Tovar-Hernández, Ellison & Young gen. nov.
Seepicola viridiplumi Rice, Tovar-Hernández, Ellison & Young, 2025, gen. nov. designated by monotypy .. Type species.
Description
Medium size species in the subfamily Myxicolinae with a moderate number of radioles arranged in semi-circular radiolar lobes. Brachial crown symmetrical, with all radioles nearly the same length. Brachial crown with basal, dorsal, and ventral flanges. Palmate membrane, radiolar flanges and radiolar eyes absent. Pinnules paired. Radiolar tips entire (unbranched). Dorsal lips with mid rib (radiolar appendages) and dorsal pinnular appendages. Ventral lips and parallel lamellae present. Ventral sacs absent. Ventral peristomial chambers present, located between the ventral lappets and parallel lamellae. Peristomial loops absent. Peristomial eyes present. Collar chaete narrowly hooded. Glandular ridge on chaetiger 2 absent. Ventral shields are well differentiated. Thoracic chaetae with a superior group of narrowly hooded chaete, inferior group with paleate chaetae. Neurochaetae with tear-drop shaped companion chaetae and avicular uncini. Teeth above the main fan of equal size, hood absent, breast well-developed, expanded, handles of medium length. Interamal eyespots absent. Abdominal chaetae elongate, broadly hooded. Abdominal avicular uncini with teeth above the main fang of equal size, breast well developed, short handled. Pygidium without anal cirrus. Pygidial eyes absent.
Etymology
The genus name refers to the fact that the type species was found in hydrocarbon seep habitats (Seeps, combined with the latin - cola = ' dweller'). It should be regarded as an invariant compound noun in apposition (Read et al. 2017; pg. 19).
description: Published as part of Rice, Lauren N., Tovar-Hernández, María Ana, Ellison, Christina I. & Young, Craig M., 2025, A new genus and species of feather duster worm (Annelida, Sabellidae) from shallow hydrocarbon seeps in the Gulf of Mexico, pp. e 139552 in Biodiversity Data Journal 13 on page e139552, DOI: 10.3897/BDJ.13.e139552
The genomic basis of parasitism in the Strongyloides clade of nematodes
Creators: name: Hunt, VL
name: Tsai, IJ
name: Coghlan, A
name: Reid, AJ
name: Holroyd, N
name: Foth, BJ
name: Tracey', A
name: Cotton', JA
name: Stanley, EJ
name: Beasley, H
name: Bennett, HM
name: Brooks, K
name: Harsha, B
name: Kajitani, R
name: Kulkarni, A
name: Harbecke, D
name: Nagayasu, E
name: Nichol, S
name: Ogura, Y
name: Quail, MA
name: Randle, N
name: Xia, D
name: Brattig, NW
name: Soblik, H
name: Ribeiro, DM
name: Sanchez-Flores, A
name: Hayashi, T
name: Itoh, T
name: Denver, DR
name: Grant, Warwick
name: Stoltzfus, JD
name: Lok, JB
name: Murayama, H
name: Wastling, J
name: Streit, A
name: Kikuchi, T
name: Viney, M
name: Berriman, M
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 3001
subject: Agricultural biotechnology
subject: FOS: Agricultural biotechnology
classificationCode: 300909
subject: Veterinary parasitology
classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3102
subject: Bioinformatics and computational biology
classificationCode: 3105
subject: Genetics
classificationCode: 3107
subject: Microbiology

description: Soil-transmitted nematodes, including the Strongyloides genus, cause one of the most prevalent neglected tropical diseases. Here we compare the genomes of four Strongyloides species, including the human pathogen Strongyloides stercoralis, and their close relatives that are facultatively parasitic (Parastrongyloides trichosuri) and free-living (Rhabditophanes sp. KR3021). A significant paralogous expansion of key gene families - families encoding astacin-like and SCP/TAPS proteins - is associated with the evolution of parasitism in this clade. Exploiting the unique Strongyloides life cycle, we compare the transcriptomes of the parasitic and free-living stages and find that these same gene families are upregulated in the parasitic stages, underscoring their role in nematode parasitism.
Sailings and fares to and from the Orient via Honolulu or direct express
Creators: name: Canadian Pacific Steamships
name: Crawford, Lawrence
Publisher: name: Montreal : Canadian Pacific Steamships
Year: 2018

description: Schedules and prices for Canadian Pacific ships heading to Asia. Pamphlet TP 48. Assembled by Lawrence Crawford, orchestra leader on the Canadian Pacific second Empress of Japan, Princess Louise, and Princess Alice.
Koechlin, Nicolas, & Frères
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1825

description: Ort: Mulhouse
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Kampermann & Co
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1825

description: Ort: Barmen
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Functional assessments used by occupational therapists with older adults at risk of activity and participation limitations: a systematic review
Creators: name: Wales, K
name: Clemson, L
name: Lannin, Natasha
name: Cameron, I
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4201
subject: Allied health and rehabilitation science
classificationCode: 4203
subject: Health services and systems

description:   
Introduction: The use of functional assessments to evaluate patient change is complicated by a lack of consensus as to which assessment is most suitable for use with older adults. Objective: To identify and appraise the properties of assessments used to evaluate functional abilities in older adults.
Methods: A systematic review of randomised controlled trials of occupational therapy interventions was conducted up to 2012 to identify assessments used to measure function. Two authors screened and extracted data independently. A second search then identified papers investigating measurement properties of each assessment. Studies from the second search were included if: i) published in English, ii) the assessment was not modified from its original published form, iii) study aim was to evaluate the quality of the tool, iv) and was original research. Translated versions of assessments were excluded. Measurement quality was rated using the COSMIN checklist and Terwee criteria.
Results: Twenty-eight assessments were identified from the systematic search of occupational therapy interventions provided to older adults. Assessments were of varied measurement quality and many had been adapted (although still evaluated as though the original tool had been administered) potentially altering the conclusions drawn about measurement quality. Synthesis of best evidence established 15 functional assessments have not been tested in an older adult population.
Conclusions: The Functional Autonomy Measurement System (SMAF) appears to be a promising assessment for use with older adults. Only two tools (the SMAF and the Assessment of Motor and Process Skills (AMPS)) were deemed to be responsive to change when applied to older adults. Health professionals should use functional assessments that have been validated with their population and in their setting. There are reliable and valid assessments to capture the functional performance of older adults in community and hospital settings, although further refinement of these assessments may be necessary.
Iselin, Gebrüder
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1825

description: Ort: Basel
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
The Resonant Universe: A Suppression-Driven Cosmological Framework for Quantum-Driven Structure Formation and Gravitational Wave Echoes
Creators: name: Tomlinson, Simon
Publisher: name: Zenodo
Year: 2025

description: We present a novel cosmological model where quantum resonance and suppression fields govern the large-scale structure formation, cosmic expansion, and gravitational wave echoes. This framework integrates quantum decoherence, dimensional resonance effects, and non-particle explanations for dark matter, providing predictive insights beyond ΛCDM and standard cosmology. We validate this approach through empirical comparisons with LIGO/Virgo gravitational wave data and observed cosmic structures.
Identification and characterisation of somatic regulatory mutations in the breast cancer genome
Creators: name: Slaven, Neil David
Publisher: name: Imperial College London
Year: 2021

description: Luminal breast cancer remains a major clinical challenge with over 2 million cases diagnosed annually. While prognosis is favourable in these patients, roughly 40% will relapse over the course of the next 20 years. Understanding the evolution of disseminated tumour cells at distal sites is critical to effectively treating these patients. While metastatic driver mutations, such as those in the Oestrogen Receptor (ESR1) gene, can be identified in many cases for a significant proportion of patients, clear drivers remain elusive. A limitation of previous genomics studies in metastatic breast cancer is their focus on the coding genome. Advances in our understanding have revealed the critical role of regulatory elements such as enhancers and promoters in transcriptional regulation. This effect is mediated through the functional and hierarchical organisation of chromatin within the nucleus, the key unit of chromatin organisation is the Topologically Associating Domains (TADs). TAD organisation is, in part, mediated by the CCCTC-Binding Factor (CTCF) protein which physically binds to DNA mediating the formation of loops and domains. Together promoters, enhancers, and CTCF-bound regions provide potential as sites for non-coding mutations to occur, drastically impacting gene regulation and tumour evolution. In this work we interrogate the contribution of regulatory element mutations in the evolution of metastatic breast cancer. This is done through two projects. First, a proof of principle study functionally characterising a clinically relevant CTCF binding site mutation. Second, through the design of an informed panel of regulatory regions utilised in a longitudinal targeted sequencing study in patient samples and a CRISPRi perturbation study in cell lines. Through these studies we provide evidence that the mutation of TAD boundary associated CTCF binding sites is unlikely to contribute to tumour evolution. We also fail to identify recurrence of non-coding drivers, though more patient specific mutations may contribute to metastatic evolution. Results obtained from the CRISPRi screen illustrate the functionality of the regulatory regions in the panel, identifying regulatory elements that confer fitness or vulnerabilities when specifically repressed. This study identifies that repression of several members of the NF-κB signalling pathway provides MCF7 cells with an advantage in adapting to oestrogen deprivation. This data underlines the importance of regulatory regions in the evolution of luminal breast cancers and indicates that non-genetic mechanisms may play a key role.
Jaeger, Wilhelm, & Zentgraff
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1825

description: Ort: Messina
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Köncke & Edlefsen
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1825

description: Ort: Hamburg
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Ratsbeschluss
Creators: name: Basel
Publisher: name: [s.n.]
Year: 1597

description: Beschluss über die Reiterstatue des Heiligen Martin am Münster, dass dieselbe zu bleiben habe als Gezierd, aber mit Stein- oder Kesselfarbe angestrichen werden solle, welches den Herren Ministris nicht zum Ärgernis gereichen solle. (nach Verzeichnis HSS Ki.-Ar.)
description: Rat zu Basel
description: Bl. 318v-319: leer
description: Deutsch
description: Verzeichnung=Description=Inventaire Juli 2021 HAN-Katalogisierungsregeln Vollständige Rekatalogisierung nach Verzeichnis HSS Ki.-Ar. und Original tri
Sammelhandschrift
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1300

description: Öffentliche Bibliothek der Universität Basel
description: Latein
description: Pertz, Georg Heinrich. - Reise nach der Schweiz und Savoyen, im August und September 1837. In: Archiv der Gesellschaft für ältere deutsche Geschichtskunde ; 7 (1839), S. 168-182, hier S. 174
description: Bataillon, Louis-Jacques J./Bériou, Nicole. - G. de Mailly de l'ordre des frères prêcheurs. In: Archivum fratrum Praedicatorum ; 61 (1991), S. 5-88, hier S. 63 146vb-242rb
description: Neidiger, Bernhard. - Selbstverständnis und Erfolgschancen der Dominikanerobservanten. In: Rottenburger Jahrbuch für Kirchengeschichte ; 17 (1998), S. 67-122, hier S. 106 Anm. 202
description: Verzeichnung=Description=Inventaire 2008 Titel, Jahr, Sprache, Signatur, Vorbesitzer nach: Meyer/Burckhardt
description: Digitalisierung=Digitization=Numérisation Mai 2023 TIFF
description: Erschliessungsniveau Minimalniveau
Strain-transcending immune response generated by chimeras of the malaria vaccine candidate merozoite surface protein 2
Creators: name: Krishnarjuna, B
name: Andrew, D
name: MacRaild, CA
name: Morales, RAV
name: Beeson, JG
name: Anders, Robin
name: Richards, JS
name: Norton, RS
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences
classificationCode: 3207
subject: Medical microbiology

description: MSP2 is an intrinsically disordered protein that is abundant on the merozoite surface and essential to the parasite Plasmodium falciparum. Naturally-acquired antibody responses to MSP2 are biased towards dimorphic sequences within the central variable region of MSP2 and have been linked to naturally-acquired protection from malaria. In a phase IIb study, an MSP2-containing vaccine induced an immune response that reduced parasitemias in a strain-specific manner. A subsequent phase I study of a vaccine that contained both dimorphic forms of MSP2 induced antibodies that exhibited functional activity in vitro. We have assessed the contribution of the conserved and variable regions of MSP2 to the generation of a strain-transcending antibody response by generating MSP2 chimeras that included conserved and variable regions of the 3D7 and FC27 alleles. Robust anti-MSP2 antibody responses targeting both conserved and variable regions were generated in mice, although the fine specificity and the balance of responses to these regions differed amongst the constructs tested. We observed significant differences in antibody subclass distribution in the responses to these chimeras. Our results suggest that chimeric MSP2 antigens can elicit a broad immune response suitable for protection against different strains of P. falciparum.
Imperatori, Vincenzo & Fratelli
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1825

description: Ort: Arona
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Epidemiology, healthcare resource utilisation, identification, and outcomes of different heart failure phenotypes in real world
Creators: name: Sundaram, Varun
Publisher: name: Imperial College London
Year: 2021

description: While international guidelines for the management of heart failure (HF) largely overlap, important regional differences exist in patient characteristics, prescription patterns, healthcare resource utilisation and consequently, in clinical outcomes, between the Western and Asian countries. To date, comparative data on geographic differences in patient characteristics, management and outcomes has either been based on post-hoc analyses from clinical trials, aggregate patient data or from registries that lacked both quantum and generalisability. I therefore performed an individual patient-level analysis of more than one million non-consecutive heart failure hospitalisations across four countries – UK, US, Japan, and Taiwan – using nationally representative electronic health care records (EHR), which captured routine clinical encounters (Specific Aims 1 and 2). Although, multiple studies have been undertaken to efficiently identify patients with HF in the real world using EHR, there is a paucity of evidence on identification and validation of algorithms for identifying patients with specific HF phenotypes, including heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF). As part of specific aim 3, I have focussed on improving the ability to identify patients with different HF phenotypes within the EHR, by collecting additional data (including direct questionnaire to General Practitioner’s), and by seeking to understand the impact of different algorithms for identification of HFrEF and HFpEF. HFpEF patients are widely believed to be a heterogenous and can be broadly categorised into two further sub-phenotypes at the population level: 1) young obese patients and 2) older non-obese patients where hypertension, chronic kidney disease, coronary artery disease (CAD) and atrial fibrillation are the predominant drivers. As part of specific aims 4 and 5, I have evaluated the obese HFpEF sub-phenotype and the impact of coronary revascularisation in patients with HFpEF (CAD-HFpEF sub-phenotype) using nationwide EHR.
Kaisser, Max Ludwig
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1825

description: Ort: Freiburg i. Br.
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
ECONOMIC IMPLICATIONS OF TARIFFS AND TRADE BARRIERS
Creators: name: Norkobilov, Akobir
Publisher: name: Zenodo
Year: 2024

description: This research explores the economic implications of tariffs and trade barriers, examining their impact on domestic industries, consumer prices, global supply chains, and overall economic growth. Utilizing contemporary and historical data, the study highlights the complex interplay between protectionist policies and market efficiency. Key examples include the U.S. – China trade war, which significantly disrupted global trade, and the European Union’s non-tariff barriers, which impose substantial costs on businesses. The analysis reveals that while tariffs and trade barriers can protect domestic jobs and generate government revenue, they often lead to higher consumer prices, reduced economic efficiency, and strained international relations. This research underscores the need for a balanced approach to trade policy that considers both the benefits and drawbacks of protectionist measures.
Israel, Joseph Elias
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1825

description: Ort: Schwerin
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Irmtraut, Freiherr, von
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1825

description: Ort: Stuttgart
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Kindervater, Gebrüder
Creators: name: [s.n.]
Publisher: name: [s.n.]
Year: 1825

description: Ort: Ulm
description: Verzeichnung=Description=Inventaire 05.07.2020 Automatisiert nach HAN-Import
description: Verzeichnung=Description=Inventaire ISAD(G) / HAN Katalogisierungsregeln für Archivbestände Detailliert
Achieving Effective Internal Control Over Sustainability Reporting
Creators: name: Thomson, Jeffrey
Publisher: name: University of Notre Dame
Year: 2025
Subjects: classificationCode: 41
subject: Environmental sciences

description: The ISSB issued IFRS S1 and S2 for consistent climate reporting, with IFRS S2 effective in 2024. The SEC is developing rules for climate and ESG reporting. COSO released guidance on internal controls for sustainability reporting (ICSR) to enhance trust, as studies show distrust in ESG data. The COSO framework aligns financial and non-financial reporting, benefiting businesses of all sizes. It helps prevent greenwashing, integrates ESG into decision-making, and ensures reliable sustainability reporting.
Align-and-repeat: one-shot visual imitation learning using imagination
Creators: name: Uzun, Murat
Publisher: name: Imperial College London
Year: 2021

description: Visual imitation learning is a compelling framework that enables robotic agents to perform tasks using expert demonstrations. It is, however, currently too costly to collect high-quality expert behavior, as it requires manual kinesthetic teaching or tele-operation. Furthermore, as deep learning stays at the foundation of raw sensory input processing, it is possible to observe erroneous imitation behavior, especially when the operating conditions are not fully covered by the training data. In this work, we initially study the predictive uncertainty estimations in deep learning comparing the most commonly used methods in the literature from the robotic object manipulation context. Our empirical analysis exposes the involved challenges of uncertainty calibration and out-of-distribution robustness of neural network models. We then propose a practical method for one-shot visual imitation that enables robots to solve a number of everyday table-top manipulation tasks using a single expert demonstration. Our method does not assume any task-relevant prior knowledge and 3D object models. The expert demonstration, i.e., end-effector velocities, is collected together with the corresponding depth measurements using a calibrated wrist-cam. For each task, we divide the robot motion into two phases: the view-point alignment and the interaction. The proposed approach first learns to reconstruct an orthographic render of the workspace via an encoder-decoder type neural scene rendering model that is trained offline. Imagined full top-down render of the live scene, including the unexplored and occluded regions, is then used to guide the end-effector for task-relevant visual information collection. After sufficient visual exploration, the first frame of the live scene is aligned with the first frame of the demonstration scene via estimating a rigid transformation matrix, so that, we can simply repeat the expert actions. This allows executing complex behavior, i.e., 3D trajectory, without explicitly learning a policy. We conduct a number of manipulation experiments in simulation comparing our approach with similar baselines and illustrate its superior performance.
By moonlighting in the nucleus, Villin regulates epithelial plasticity
Creators: name: Patnaik, S
name: George, SP
name: Pham, E
name: Roy, S
name: Singh, K
name: Mariadason, John
name: Khurana, S
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3101
subject: Biochemistry and cell biology

description: Villin is a tissue-specific, actin-binding protein involved in the assembly and maintenance of microvilli in polarized epithelial cells. Conversely, villin is also linked with the loss of epithelial polarity and gain of the mesenchymal phenotype in migrating, invasive cells. In this study, we describe for the first time how villin can switch between these disparate functions to change tissue architecture by moonlighting in the nucleus. Our study reveals that the moonlighting function of villin in the nucleus may play an important role in tissue homeostasis and disease. Villin accumulates in the nucleus during wound repair, and altering the cellular microenvironment by inducing hypoxia increases the nuclear accumulation of villin. Nuclear villin is also associated with mouse models of tumorigenesis, and a systematic analysis of a large cohort of colorectal cancer specimens confirmed the nuclear distribution of villin in a subset of tumors. Our study demonstrates that nuclear villin regulates epithelial-mesenchymal transition (EMT). Altering the nuclear localization of villin affects the expression and activity of Slug, a key transcriptional regulator of EMT. In addition, we find that villin directly interacts with a transcriptional corepressor and ligand of the Slug promoter, ZBRK1. The outcome of this study underscores the role of nuclear villin and its binding partner ZBRK1 in the regulation of EMT and as potential new therapeutic targets to inhibit tumorigenesis.
Multi-scale computer models of lymphatic pumping
Creators: name: Morris, Christopher James
Publisher: name: Imperial College London
Year: 2021

description: The lymphatic system maintains fluid homeostasis by returning interstitial fluid to the veins. Lymphatics pump fluid locally with contracting segments of the vessel (lymphangions) bounded by valves. Contractions are generated by specialized muscle exhibiting phasic and tonic contractions. Deficient pumping can result in accumulation of interstitial fluid, called lymphoedema. Lymphoedema treatments have limited effectiveness, partially attributable to a lack of understanding of contractions. A lumped parameter computational model of lymphangion pumping has previously been developed in the group. In this thesis I detail development of two multiscale models of lymphatic pumping to facilitate improved treatments for lymphoedema. The first model captures subcellular mechanisms of lymphatic muscle contraction. This model is based on the sliding filament model and its smooth muscle adaptation. Contractile elements are combined with passive viscoelastic elements to model a cell. Many arrangements were trialled but only one behaved physiologically. The muscle model was then combined with the lymphangion model for comparison with experiments. This model captures mechanical and energetic aspects of both contraction types. I show that the model provides results similar to published experiments from rat mesenteric lymphatics. The model predicted a peak efficiency of 35%, in the upper range from other muscle types. In the range of frequencies and amplitudes simulated, the direct effect of calcium oscillations can increase lymphangion outflow by up to 40% of the flow in their absence. The second model aims to improve our understanding of lymphangion interaction in large networks through computational homogenisation. In this model we do not directly simulate all lymphangions but sample lymphangions at evenly spaced intervals to reduce the computational intensity. We show through this model that increased external pressure at the network inlet collapses lymphangions and that this disruption of pumping for a few lymphangions reduces the outflow from the entire network.
Identifying stable reference genes for qRT-PCR normalisation in gene expression studies of narrow-leafed lupin (Lupinus angustifolius L.)
Creators: name: Taylor, Candy M
name: Jost, Ricarda
name: Erskine, W
name: Nelson, MN
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 30
subject: Agricultural, veterinary and food sciences
classificationCode: 3004
subject: Crop and pasture production

description: Quantitative Reverse Transcription PCR (qRT-PCR) is currently one of the most popular, high-throughput and sensitive technologies available for quantifying gene expression. Its accurate application depends heavily upon normalisation of gene-of-interest data with reference genes that are uniformly expressed under experimental conditions. The aim of this study was to provide the first validation of reference genes for Lupinus angustifolius (narrow-leafed lupin, a significant grain legume crop) using a selection of seven genes previously trialed as reference genes for the model legume, Medicago truncatula. In a preliminary evaluation, the seven candidate reference genes were assessed on the basis of primer specificity for their respective targeted region, PCR amplification efficiency, and ability to discriminate between cDNA and gDNA. Following this assessment, expression of the three most promising candidates [Ubiquitin C (UBC), Helicase (HEL), and Polypyrimidine tract-binding protein (PTB)] was evaluated using the NormFinder and RefFinder statistical algorithms in two narrow-leafed lupin lines, both with and without vernalisation treatment, and across seven organ types (cotyledons, stem, leaves, shoot apical meristem, flowers, pods and roots) encompassing three developmental stages. UBC was consistently identified as the most stable candidate and has sufficiently uniform expression that it may be used as a sole reference gene under the experimental conditions tested here. However, as organ type and developmental stage were associated with greater variability in relative expression, it is recommended using UBC and HEL as a pair to achieve optimal normalisation. These results highlight the importance of rigorously assessing candidate reference genes for each species across a diverse range of organs and developmental stages. With emerging technologies, such as RNAseq, and the completion of valuable transcriptome data sets, it is possible that other potentially more suitable reference genes will be identified for this species in future.
Physiological and transcriptome responses to combinations of elevated CO2 and magnesium in Arabidopsis thaliana
Creators: name: Y Niu
name: GJ Ahammed
name: Caixian Tang
name: L Guo
name: J Yu
Publisher: name: La Trobe
Year: 2021
Subjects: Uncategorized

description: © 2016 Niu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The unprecedented rise in atmospheric CO2 concentration and injudicious fertilization or heterogeneous distribution of Mg in the soil warrant further research to understand the synergistic and holistic mechanisms involved in the plant growth regulation. This study investigated the influence of elevated CO2 (800 μL L-1) on physiological and transcriptomic profiles in Arabidopsis cultured in hydroponic media treated with 1 μM (low), 1000 μM (normal) and 10000 μM (high) Mg2+. Following 7-d treatment, elevated CO2 increased the shoot growth and chlorophyll content under both low and normal Mg supply, whereas root growth was improved exclusively under normal Mg nutrition. Notably, the effect of elevated CO2 on mineral homeostasis in both shoots and roots was less than that of Mg supply. Irrespective of CO2 treatment, high Mg increased number ofyoung leaf but decreased root growth and absorption of P, K, Ca, Fe and Mn whereas low Mg increased the concentration of P, K, Ca and Fe in leaves. Transcriptomics results showed that elevated CO2 decreased the expression of genes related to cell redox homeostasis, cadmium response, and lipid localization, but enhanced signal transduction, protein phosphorylation, NBS-LRR disease resistance proteins and subsequently programmed cell death in low-Mg shoots. By comparison, elevated CO2 enhanced the response of lipid localization (mainly LTP transfer protein/protease inhibitor), endomembrane system, heme binding and cell wall modification in high-Mg roots. Some of these transcriptomic results are substantially in accordance with our physiological and/or biochemical analysis. The present findings broaden our current understanding on the interactive effect of elevated CO2 and Mg levels in the Arabidopsis, which may help to design the novel metabolic engineering strategies to cope with Mg deficiency/excess in crops under elevated CO2.
The use of self-report questions to examine the prevalence of musculoskeletal problems: a test-retest study
Creators: name: Gill, TK
name: Tucker, GR
name: Avery, JC
name: Shanahan, EM
name: Menz, Hylton
name: Taylor, AW
name: Adams, RJ
name: Hill, CL
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 32
subject: Biomedical and clinical sciences
classificationCode: 3202
subject: Clinical sciences
classificationCode: 42
subject: Health sciences
subject: FOS: Health sciences
classificationCode: 4201
subject: Allied health and rehabilitation science
classificationCode: 4207
subject: Sports science and exercise

description: Background: Case definition has long been an issue for comparability of results obtained for musculoskeletal pain prevalence, however the test-retest reliability of questions used to determine joint pain prevalence has not been examined. The objective of this study was to determine question reliability and the impact of question wording, ordering and the time between questions on responses. Methods: A Computer Assisted Telephone Interviewing (CATI) survey was used to re-administer questions collected as part of a population-based longitudinal cohort study. On two different occasions questions were asked of the same sample of 203 community dwelling respondents (which were initially randomly selected) aged 18 years and over at two time points 14 to 27 days apart (average 15 days). Reliability of the questions was assessed using Cohen's kappa (κ) and intraclass correlation coefficient (ICC) and whether question wording and period effects existed was assessed using a crossover design. Results: The self-reported prevalence of doctor diagnosed arthritis demonstrated excellent reliability (κ = 0.84 and κ = 0.79 for questionnaires 1 and 2 respectively). The reliability of questions relating to musculoskeletal pain and/or stiffness ranged from moderate to excellent for both types of questions, that is, those related to ever having joint pain on most days for at least a month (κ = 0.52 to κ = 0.95) and having pain and/or stiffness on most days for the last month (κ = 0.52 to κ = 0.90). However there was an effect of question wording on the results obtained for hand, foot and back pain and/or stiffness indicating that the area of pain may influence prevalence estimates. Conclusions: Joint pain and stiffness questions are reliable and can be used to determine prevalence. However, question wording and pain area may impact on estimates with issues such as pain perception and effect on activities playing a possible role in the recall of musculoskeletal pain.
Vortex-lattice-based nonlinear aeroservoelastic modelling and analysis of large floating wind turbines
Creators: name: Muñoz Simón, Arturo
Publisher: name: Imperial College London
Year: 2021

description: Wind turbine blades have significantly increased in length over the last few decades and are being operated in increasingly complex inflows such as the wake of other wind turbines or on floating platforms. This is increasing the unsteady and three-dimensional aerodynamic effects and the nonlinear structural dynamics that are neglected by the industry-standard Blade-Element Momentum and linear structural theories, respectively. In this dissertation, we employ Unsteady Vortex-Lattice Method for the aerodynamics and nonlinear Geometrically-Exact Beam Theory for the structural dynamics computations to describe these phenomena and their role on wind turbine aeroelasticity. We show that, Unsteady Vortex-Lattice Method fails to provide accurate drag estimation that we overcome with a semiempirical correction to include drag from steady-state tabulated data. We also show that, in cases of yaw, Blade-Element Momentum theory predicts accurate root-bending moments and rotor coefficients up to about ten degrees of yaw, for larger yaw angles, it over estimates the loads decay with the yaw angle. Furthermore, the interaction between radial sections of the blade under turbulent inflow is significant but not accounted for by Blade-Element Momentum theory so we study this phenomenon with Unsteady Vortex-Lattice Method and propose a correction to include the interaction between blade sections in Blade-Element Momentum theory that improves the prediction of loads along the span. We also reduce the computational cost of the Unsteady Vortex-Lattice Method by proposing a new wake discretisation scheme of the wake convection equation. We study the change in aerodynamic surface orientation in long flexible blades and conclude that capturing the twist degree of freedom is important for loads and power estimation. Moreover, we describe the influence of the platform pitch and roll motions in the unsteady character of the aerodynamic loads. Finally, we redesign the controller of the blade pitch to account for nonlinear structural dynamics and unsteady aerodynamics showing a reduction in the fluctuations of the main platform motions and energy production around the equilibrium position.
Assessing the Hydraulic Performance of Flow Impact on Bridge Structures: The Case of Saris and Lafto Bridges in Addis Ababa, Ethiopia
Creators: name: GEZAHAGN GETISO
Publisher: name: Zenodo
Year: 2020

description: Assessing the Hydraulic Performance of Flow Impact on Bridge Structures: The 

Case of Saris and Lafto Bridges in Addis Ababa, Ethiopia
Elizabeth Usher Memorial Lecture: Language is literacy is language - Positioning speech-language pathology in education policy, practice, paradigms and polemics
Creators: name: Snow, Pamela
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 4201
subject: Allied health and rehabilitation science
classificationCode: 47
subject: Language, communication and culture
classificationCode: 4704
subject: Linguistics
subject: FOS: Languages and literature

description: This paper is concerned with the fundamental and intrinsic links between early receptive and expressive oral language competence on the one hand and the transition to literacy in the early school years and achievement of academic (and life) success on the other. Consequently, it also concerns the professional knowledge base of two key disciplines whose work is central to children’s early language and literacy success: teachers and speech-language pathologists (SLPs). Oral language competence underpins the transition to literacy, which in turn underpins academic achievement. Academic achievement is significant in its own right, conferring opportunities for further education and training post-secondary school, contributing to psychological health and mitigating some of the mental health risks and adversities that can be associated with adolescence and early adulthood. The central thesis is that the linguistic basis of the transition to literacy makes early reading success core business for SLPs. Further, SLPs need a firm grasp of the political and ideological factors that have exerted historical and continuing influence on reading instruction in western nations such as Australia, the US and the UK. This will facilitate the establishment of meaningful working relationships with teaching colleagues, to achieve optimal education outcomes for all children.
On Communication Through a Gaussian Channel With an MMSE Disturbance Constraint
Creators: name: Dytso, Alex
name: Bustin, Ronit
name: Tuninetti, Daniela
name: Devroye, Natasha
name: Poor, H Vincent
name: Shitz, Shlomo Shamai
Publisher: name: University of Illinois at Chicago
Year: 2022
Subjects: subject: Artificial Intelligence and Image Processing
subject: FOS: Computer and information sciences

description: This paper considers a Gaussian channel with one transmitter and two receivers. The goal is to maximize the communication rate at the intended/primary receiver subject to a disturbance constraint at the unintended/secondary receiver. The disturbance is measured in terms of the minimum mean square error (MMSE) of the interference that the transmission to the primary receiver inflicts on the secondary receiver. This paper presents a new upper bound for the problem of maximizing the mutual information subject to an MMSE constraint. The new bound holds for vector inputs of any length and recovers a previously known limiting (when the length of the vector input tends to infinity) expression from the work of Bustin et al. The key technical novelty is a new upper bound on the MMSE. This bound allows one to bound the MMSE for all signal-to-noise ratio (SNR) values below a certain SNR at which the MMSE is known (which corresponds to the disturbance constraint). The bound also complements the “single-crossing point property” of the MMSE that upper bounds the MMSE for all SNR values above a certain value at which the MMSE value is known. The MMSE upper bound provides a refined characterization of the phase-transition phenomenon, which manifests, in the limit as the length of the vector input goes to infinity, as a discontinuity of the MMSE for the problem at hand. For vector inputs of size n = 1, a matching lower bound, to within an additive gap of order O(log log(1/MMSE)) (where MMSE is the disturbance constraint), is shown by means of the mixed inputs technique recently introduced by Dytso et al.
File Locking Control in HDF5 1.10.x
Creators: name: Robinson, Dana
Publisher: name: Zenodo
Year: 2016

description: Version 1.10 of the HDF5 library uses a file locking scheme to help prevent reader/writer access patterns that can cause library errors, particularly with respect to the singlewriter/multiple-readers (SWMR) access pattern. Although this scheme works well for many users, it has come to our attention that it can cause problems for others. Additional control over the file locking scheme would mitigate the issues that have been described to us.

This RFC provides an overview of the locking scheme, describes the problems that users have been encountering, and proposes some solutions. The implementation of the solutions are targeted for HDF5 1.10.1 (target release date: December 2016).
Diary
Creators: name: MacDonell, Father Andrew
Publisher: name: [place of publication unknown] : Knickerbocker Leather & Novelty Co., Inc
Year: 2015

description: MacDonell's 1938 diary is sparsely written in and recounts his travels, correspondence, and daily activities. He sailed from Honolulu to Victoria on February 4 and arrived February 10. Returned to Edmonton and visited Clandonald. Includes cash accounts in back of book.
Canadian Pacific Steamships agent's stubs
Creators: name: Yip Sang Company
name: Canadian Pacific Steamships
Publisher: name: The University of British Columbia
Year: 2016

description: Ticket stubs for the following passengers: Chew Yee [Gip], Lim Foo Chun, Fong Chan Jang, Young Won Dang, [Gunn Wing], Ho Kim So, Louie Eng, Lim Hong, Lew Shing.
Materials Design of Complex Dielectric Crystals
Creators: name: Morita, Kazuki
Publisher: name: Imperial College London
Year: 2022

description: Dielectric materials are insulators that can screen an external electric field. These materials are used in capacitors, high power applications, computer chips, and sensors, making them an essential part of today's electronic technology. The screening in these materials can originate from dipoles of various length scales, but the electronic and ionic contributions have attracted special attention as they are intrinsic to a material. Surprisingly, a microscopic description of polarisation was only formulated two decades ago, and its calculation became computationally feasible only recently. In light of this progress, it is timely to use these to develop new dielectric materials. In contrast to the conventional characterisation approach, where theoretical works follow experiments, this ``materials design'' approach aims to suggest new dielectric materials or new usage of conventional dielectric materials a priori to experimental findings. In this thesis, I show that a combination of conventional electronic structure methods and data science tools can be used synergistically to design dielectric materials. This thesis consists of three main results. Firstly, new properties of conventional materials are probed using electronic structure theory, in particular the dipole induced by F-doping in non-polar Ruddlesden-Popper phase Sr3Ti2O7 is discussed. Next, electronic structure calculation are combined with data science methods, to analyse the permittivity of 1364 materials. Finally, a fully data-oriented method for analysing distortions in dielectric materials is shown. Together these studies show the strength of combining conventional electronic structure and data science techniques and that their balance can be adjusted according to the problem of interest. These studies not only open a new path towards next-generation dielectric materials, but the methodologies are also significant as many of them are either newly developed or newly imported from different scientific fields. Therefore, works in this thesis are likely to promote further material discoveries.
Data publication with the structural biology data grid supports live analysis
Creators: name: Meyer, PA
name: Socias, S
name: Key, J
name: Ransey, E
name: Tjon, EC
name: Buschiazzo, A
name: Lei, M
name: Botka, C
name: Withrow, J
name: Neau, D
name: Rajashankar, K
name: Anderson, KS
name: Baxter, RH
name: Blacklow, SC
name: Boggon, TJ
name: Bonvin, AMJJ
name: Borek, D
name: Brett, TJ
name: Caflisch, A
name: Chang, C-I
name: Chazin, WJ
name: Corbett, KD
name: Cosgrove, MS
name: Crosson, S
name: Dhe-Paganon, S
name: Di, E
name: Drennan, CL
name: Eck, MJ
name: Eichman, BF
name: Fan, QR
name: Ferre-D'Amare, AR
name: Fromme, JC
name: Garcia, KC
name: Gaudet, R
name: Gong, P
name: Harrison, SC
name: Heldwein, EE
name: Jia, Z
name: Keenan, RJ
name: Kruse, AC
name: Kvansakul, Marc
name: McLellan, JS
name: Modis, Y
name: Nam, Y
name: Otwinowski, Z
name: Pai, EF
name: Pereira, PJ Barbosa
name: Petosa, C
name: Raman, S
name: Rapoport, TA
name: Roll-Mecak, A
name: Rosen, MK
name: Rudenko, G
name: Schlessinger, J
name: Schwartz, TU
name: Shamoo, Y
name: Sondermann, H
name: Tao, YJ
name: Tolia, NH
name: Tsodikov, OV
name: Westover, KD
name: Wu, H
name: Foster, I
name: Fraser, JS
name: Maia, FRNC
name: Gonen, T
name: Kirchhausen, T
name: Diederichs, K
name: Crosas, M
name: Sliz, P
Publisher: name: La Trobe
Year: 2023
Subjects: classificationCode: 31
subject: Biological sciences
subject: FOS: Biological sciences
classificationCode: 3101
subject: Biochemistry and cell biology

description: Access to experimental X-ray diffraction image data is fundamental for validation and reproduction of macromolecular models and indispensable for development of structural biology processing methods. Here, we established a diffraction data publication and dissemination system, Structural Biology Data Grid (SBDG; data.sbgrid.org), to preserve primary experimental data sets that support scientific publications. Data sets are accessible to researchers through a community driven data grid, which facilitates global data access. Our analysis of a pilot collection of crystallographic data sets demonstrates that the information archived by SBDG is sufficient to reprocess data to statistics that meet or exceed the quality of the original published structures. SBDG has extended its services to the entire community and is used to develop support for other types of biomedical data sets. It is anticipated that access to the experimental data sets will enhance the paradigm shift in the community towards a much more dynamic body of continuously improving data analysis.