cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
title: Life events and life satisfaction: Estimating effects of multiple life events in combined models
Creators: name: Krämer, Michael D.
name: Rohrer, Julia M.
name: Lucas, Richard E.
name: Richter, David
Publisher: name: Freie Universität Berlin
Year: 2025
Subjects: subject: Life events
subject: life satisfaction
subject: event co-occurrence
subject: romantic relationships
subject: childbirth
classificationCode: 150
subject: Psychologie

description: How do life events affect life satisfaction? Previous studies focused on a single event or separate analyses of several events. However, life events are often grouped non-randomly over the lifespan, occur in close succession, and are causally linked, raising the question of how to best analyze them jointly. Here, we used representative German data (SOEP; N = 40,121 individuals; n = 41,402 event occurrences) to contrast three fixed-effects model specifications: First, individual event models in which other events were ignored, which are thus prone to undercontrol bias; second, combined event models which controlled for all events, including subsequent ones, which may induce overcontrol bias; and third, our favored combined models that only controlled for preceding events. In this preferred model, the events of new partner, cohabitation, marriage, and childbirth had positive effects on life satisfaction, while separation, unemployment, and death of partner or child had negative effects. Model specification made little difference for employment- and bereavement-related events. However, for events related to romantic relationships and childbearing, small but consistent differences arose between models. Thus, when estimating effects of new partners, separation, cohabitation, marriage, and childbirth, care should be taken to include appropriate controls (and omit inappropriate ones) to minimize bias.
Structures of the entire human opioid receptor family
Creators: name: Roth B.L
name: Xu H.E
name: Zhou X.E
name: Liu W
name: Jain M.K
name: Schmitz G.P
name: Melcher K
name: Yuan Q
name: Jiang Y
name: Wang Y
name: DiBerto J.F
name: Zhuang Y
Publisher: name: Elsevier B.V.
Year: 2023

description: Opioids are effective analgesics, but their use is beset by serious side effects, including addiction and respiratory depression, which contribute to the ongoing opioid crisis. The human opioid system contains four opioid receptors (μOR, δOR, κOR, and NOPR) and a set of related endogenous opioid peptides (EOPs), which show distinct selectivity toward their respective opioid receptors (ORs). Despite being key to the development of safer analgesics, the mechanisms of molecular recognition and selectivity of EOPs to ORs remain unclear. Here, we systematically characterize the binding of EOPs to ORs and present five structures of EOP-OR-Gi complexes, including β-endorphin- and endomorphin-bound μOR, deltorphin-bound δOR, dynorphin-bound κOR, and nociceptin-bound NOPR. These structures, supported by biochemical results, uncover the specific recognition and selectivity of opioid peptides and the conserved mechanism of opioid receptor activation. These results provide a structural framework to facilitate rational design of safer opioid drugs for pain relief.
Structures of the human dopamine D3 receptor-Gi complexes
Creators: name: Melcher, K
name: Tan, Y
name: Shen, D.-D
name: Zhou, X.E
name: Jiang, H
name: Cheng, X
name: Jiang, Y
name: Zhang, Y
name: Mao, C
name: Liu, Y
name: Xu, H.E
name: Xu, P
name: Krumm, B.E
name: Huang, X.-P
name: Huang, S
name: Roth, B.L
name: Yu, X
Publisher: name: Cell Press
Year: 2021

description: Xu et al. report two cryo-EM structures of dopamine receptor D3R bound to Gi protein and D3R-selective agonists, PD128907 and the Parkinson's disease drug pramipexole. The structures reveal the basis of ligand selectivity, ligand-induced D3R activation, and selective Gi coupling by D3R. © 2021 Elsevier Inc.The dopamine system, including five dopamine receptors (D1R–D5R), plays essential roles in the central nervous system (CNS), and ligands that activate dopamine receptors have been used to treat many neuropsychiatric disorders. Here, we report two cryo-EM structures of human D3R in complex with an inhibitory G protein and bound to the D3R-selective agonists PD128907 and pramipexole, the latter of which is used to treat patients with Parkinson's disease. The structures reveal agonist binding modes distinct from the antagonist-bound D3R structure and conformational signatures for ligand-induced receptor activation. Mutagenesis and homology modeling illuminate determinants of ligand specificity across dopamine receptors and the mechanisms for Gi protein coupling. Collectively our work reveals the basis of agonist binding and ligand-induced receptor activation and provides structural templates for designing specific ligands to treat CNS diseases targeting the dopaminergic system.
Euspira Agassiz 1837
Creators: name: Sacchetti, Claudia
name: Landau, Bernard
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Littorinimorpha
Naticidae
Euspira

description: Genus Euspira Agassiz in J. Sowerby, 1837
Type species. Natica glaucinoides J. Sowerby, 1812 (Agassiz in J. Sowerby 1837: 14), by subsequent designation (Anton, 1838). Pliocene, British Isles.
description: Published as part of Sacchetti, Claudia, Landau, Bernard & Ávila, Sérgio P., 2023, The Lower Pliocene marine gastropods of Santa Maria Island, Azores: Taxonomy and palaeobiogeographic implications, pp. 1-150 in Zootaxa 5295 (1) on page 40, DOI: 10.11646/zootaxa.5295.1.1, http://zenodo.org/record/7965273
Structures of the σ2 receptor enable docking for bioactive ligand discovery
Creators: name: Kruse, A.C
name: Lyu, J
name: Shoichet, B.K
name: Huang, X.-P
name: Irwin, J.J
name: Braz, J.M
name: Moroz, Y.S
name: Webb, C.M
name: Basbaum, A.I
name: Tummino, T.A
name: Liu, Y
name: Radchenko, D.S
name: Craik, V
name: Roth, B.L
name: Alon, A
name: O’Meara, M.J
Publisher: name: Nature Research
Year: 2021

description: The σ2 receptor has attracted intense interest in cancer imaging1, psychiatric disease2, neuropathic pain3–5 and other areas of biology6,7. Here we determined the crystal structure of this receptor in complex with the clinical candidate roluperidone2 and the tool compound PB288. These structures templated a large-scale docking screen of 490 million virtual molecules, of which 484 compounds were synthesized and tested. We identified 127 new chemotypes with affinities superior to 1 μM, 31 of which had affinities superior to 50 nM. The hit rate fell smoothly and monotonically with docking score. We optimized three hits for potency and selectivity, and achieved affinities that ranged from 3 to 48 nM, with up to 250-fold selectivity versus the σ1 receptor. Crystal structures of two ligands bound to the σ2 receptor confirmed the docked poses. To investigate the contribution of the σ2 receptor in pain, two potent σ2-selective ligands and one potent σ1/σ2 non-selective ligand were tested for efficacy in a mouse model of neuropathic pain. All three ligands showed time-dependent decreases in mechanical hypersensitivity in the spared nerve injury model9, suggesting that the σ2 receptor has a role in nociception. This study illustrates the opportunities for rapid discovery of in vivo probes through structure-based screens of ultra large libraries, enabling study of underexplored areas of biology.
Study design and baseline profile for adults with type 2 diabetes in the once-weekly subcutaneous SEmaglutide randomized PRAgmatic (SEPRA) trial
Creators: name: Cziraky M
name: Soule B.P
name: Buse J.B
name: Zacherle E
name: Harty B.J
name: Mitchell J
name: Nordahl Christensen H
name: Willey V.J
Publisher: name: BMJ Publishing Group
Year: 2023

description: Introduction Once-weekly subcutaneous semaglutide, a glucagon-like peptide-1 analog, is approved in the USA as an adjunct to diet and exercise for adults with inadequately controlled type 2 diabetes (T2D) to improve glycemic control and reduce the risk of major adverse cardiovascular events in people with T2D and established cardiovascular disease. The Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes (SUSTAIN) phase III clinical trial program demonstrated the efficacy and safety of once-weekly subcutaneous semaglutide; however, determining its effectiveness in a real-world setting could support decision-making by clinicians, payers and policy makers in routine clinical practice. Research design and methods SEmaglutide PRAgmatic (SEPRA) is an ongoing open-label, randomized, pragmatic clinical trial designed to compare the effects of once-weekly subcutaneous semaglutide versus standard of care in US health-insured adults with T2D and physician-determined inadequate glycemic control. The primary end point is the proportion of participants achieving glycated hemoglobin (HbA1c) <7.0% at year 1; other key outcomes include glycemic control, weight loss, healthcare utilization, and patient-reported outcomes. Individual-level data will be collected from routine clinical practice and health insurance claims. The last patient last visit is expected by June 2023. Results Between July 2018 and March 2021, 1278 participants were enrolled from 138 study sites across the USA. At baseline, 54% were male with mean±SD age 57.4±11.1 years and body mass index 35.7±8.0 kg/m 2. Mean diabetes duration was 7.4±6.0 years and mean HbA1c was 8.5±1.6%. At baseline, concomitant antidiabetes medications included metformin, sulfonylureas, sodium-glucose co-transporter-2 inhibitors, and dipeptidyl peptidase-4 inhibitors. The majority of participants had hypertension and dyslipidemia. The trial design was self-assessed using the PRagmatic Explanatory Continuum Indicator Summary-2 tool by the study steering group and was scored 4-5 in all domains suggesting a highly pragmatic study. Conclusions SEPRA, a highly pragmatic ongoing study, will provide data on the effects of once-weekly subcutaneous semaglutide in a real-world setting when used during routine management of T2D. Trial registration number NCT03596450. Trial registration number
Triphoridae Gray 1847
Creators: name: Sacchetti, Claudia
name: Landau, Bernard
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Triphoridae

description: Family Triphoridae Gray, 1847
Triphorid s.l.
Plate 2 I
Cerithiopsis perversa Linné — Mayer 1864: 67.
Santa Maria material examined. Maximum height 3.2 mm, width 1.3 mm. DBUA-F 471-5 (1), Ponta do Castelo, Santa Maria Island, Azores, Touril Complex, Lower Pliocene.
Discussion. A single fragment of a triphorid species is present in the Santa Maria assemblages. It is missing the protoconch and neanic whorls so that the order of appearance of the spiral cords is difficult to assess. However, it seems that the middle cord might be the last to appear. Further classification is not possible.
Distribution. Lower Pliocene: Atlantic, Santa Maria Island, Azores (Mayer 1864).
description: Published as part of Sacchetti, Claudia, Landau, Bernard & Ávila, Sérgio P., 2023, The Lower Pliocene marine gastropods of Santa Maria Island, Azores: Taxonomy and palaeobiogeographic implications, pp. 1-150 in Zootaxa 5295 (1) on page 41, DOI: 10.11646/zootaxa.5295.1.1, http://zenodo.org/record/7965273
Subcortical Brain Development in Autism and Fragile X Syndrome: Evidence for Dynamic, Age- and Disorder-Specific Trajectories in Infancy
Creators: name: Kim, S.H
name: Hazlett, H.C
name: Botteron, K.N
name: John, T.S
name: MacIntyre, L
name: Evans, A.C
name: Dager, S.R
name: Gerig, G
name: Girault, J.B
name: Pandey, J
name: Styner, M.A
name: Estes, A.M
name: Schultz, R.T
name: Zwaigenbaum, L
name: Burrows, C.A
name: Swanson, M.R
name: Smith, R.G
name: Flake, L
name: Louis Collins, D
name: Elison, J.T
name: McKinstry, R.C
name: Gross, J.L
name: Piven, J
name: Weisenfeld, L.A.H
name: Fonov, V.S
name: Wolff, J.J
name: Graves, M.M
name: Shen, M.D
Publisher: name: American Psychiatric Association
Year: 2022

description: Objective: Previous research has demonstrated that the amygdala is enlarged in children with autism spectrum disorder (ASD). However, the precise onset of this enlargement during infancy, how it relates to later diagnostic behaviors, whether the timing of enlargement in infancy is specific tothe amygdala,andwhether it is specifictoASD(or present in other neurodevelopmental disorders, such as fragile X syndrome) are all unknown. Methods: Longitudinal MRIs were acquired at 6-24 months of age in 29 infants with fragile X syndrome, 58 infants at high likelihood for ASD who were later diagnosed with ASD, 212 high-likelihood infants not diagnosed with ASD, and 109 control infants (1,099 total scans). Results: Infants who developed ASD had typically sized amygdala volumes at 6 months, but exhibited significantly faster amygdala growth between 6 and 24 months, such that by 12 months theASDgroup had significantly larger amygdala volume (Cohen's d50.56) compared with all other groups. Amygdala growth rate between 6 and 12 months was significantly associated with greater social deficits at 24monthswhenthe infantswere diagnosed with ASD. Infants with fragile X syndrome had a persistent and significantly enlarged caudate volume at all ages between 6 and 24 months (d52.12), compared with all other groups, which was significantly associated with greater repetitive behaviors. Conclusions: This is the first MRI study comparing fragile X syndrome and ASD in infancy, demonstrating strikingly different patterns of brain and behavior development. Fragile X syndrome-related changes were present from 6 months of age, whereas ASD-related changes unfolded over the first 2 years of life, starting with no detectable group differences at 6 months. Increased amygdala growth rate between 6 and 12 months occurs prior to social deficits and well before diagnosis. This gradual onset of brain and behavior changes in ASD, but not fragile X syndrome, suggests an age- and disorder-specific pattern of cascading brain changes preceding autism diagnosis.
Cerithiopsis Forbes & Hanley 1850
Creators: name: Sacchetti, Claudia
name: Landau, Bernard
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Littorinimorpha
Cerithiopsidae
Cerithiopsis

description: Genus Cerithiopsis Forbes & Hanley, 1850
Type species. Murex tubercularis Montagu, 1803 (Forbes & Hanley 1850: pl. OO), by monotypy. Present-day, British Isles.
description: Published as part of Sacchetti, Claudia, Landau, Bernard & Ávila, Sérgio P., 2023, The Lower Pliocene marine gastropods of Santa Maria Island, Azores: Taxonomy and palaeobiogeographic implications, pp. 1-150 in Zootaxa 5295 (1) on page 42, DOI: 10.11646/zootaxa.5295.1.1, http://zenodo.org/record/7965273
KOMPOZITOR DILOROM OMONULLAYEVANING "YOMG'IR" QO'SHIG'I ESTRADA XONANDA VA GURUHLARI IJROSIDA
Creators: name: Ataboyeva Nigina Davlatjon qizi
name: Professor M. Bafoyev
Publisher: name: Academic Scientific Research Group
Year: 2024

description: Ushbu maqolada o’zbek estrada san’atining shakllanishi, estrada rivoji uchun ijod qilgan shaxslar , Dilorom Darvinovna Omonullayevaning “Yomg’ir” qo’shig’i taxlili haqida so’z boradi.
Cerithiopsis tubercularis
Creators: name: Sacchetti, Claudia
name: Landau, Bernard
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Littorinimorpha
Cerithiopsidae
Cerithiopsis
Cerithiopsis tubercularis

description: Cerithiopsis cf. tubercularis (Montagu, 1803)
Plate 2 J 1 -J 2
cf.* Murex tubercularis Montagu 1803: 260.
Santa Maria material examined. Maximum height 3.0 mm, width 1.2 mm. DBUA-F 1023-1 (1), Ponta do Castelo, Santa Maria Island, Azores, Touril Complex, Lower Pliocene.
Description. Last five teleoconch whorls preserved. Late teleoconch whorl almost straight sided, bearing orthocline to slightly prosocline axial ribs, 14 on penultimate whorl, overrun by three spiral cords with prominent rounded tubercles developed at sculptural intersection. Last whorl with two peribasal cords plus one further cord over base. Aperture and siphonal fasciole incomplete.
Discussion. The single fragment missing the apical whorls could well represent Cerithiopsis tubercularis Montagu, 1803, but in the absence of protoconch definitive assignment cannot be made.
Distribution. Lower Pliocene: Atlantic, Santa Maria Island, Azores (this paper).
description: Published as part of Sacchetti, Claudia, Landau, Bernard & Ávila, Sérgio P., 2023, The Lower Pliocene marine gastropods of Santa Maria Island, Azores: Taxonomy and palaeobiogeographic implications, pp. 1-150 in Zootaxa 5295 (1) on page 42, DOI: 10.11646/zootaxa.5295.1.1, http://zenodo.org/record/7965273
Boshkerria (Radfordiella) punctata Radford 1946
Creators: name: Nielsen, David H.
name: Robbins, Richard G.
name: Rueda, Leopoldo M.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Actinedida
Trombiculidae
Boshkerria
Boshkerria punctata

description: Schoengasitiella (Radfordiella) punctata Radford, 1946 a:
PAL, ORI
Schoengastiella punctata Radford, 1946 a; Wharton & Fuller 1952
Gahrliepia (Schoengastiella) punctata, Womersley 1952; Audy 1956c
Schoengastiella (Schoengastiella) punctata, Vercammen-Grandjean 1968c [punctata group]
Schoengastiella (Radfordiella) punctata, Kolebinova & Vercammen-Grandjean 1978
Schoengastiella punctata, Fernandes & Kulkarni 2003; Stekolnikov 2021
description: Published as part of Nielsen, David H., Robbins, Richard G. & Rueda, Leopoldo M., 2021, Annotated world checklist of the Trombiculidae and Leeuwenhoekiidae (1758 - 2021) (Acari: Trombiculoidea), with notes on nomenclature, taxonomy, and distribution, pp. 1-243 in Zootaxa 4967 (1) on page 31, DOI: 10.11646/zootaxa.4967.1.1, http://zenodo.org/record/4745510
Dizoniopsis Sacco 1895
Creators: name: Sacchetti, Claudia
name: Landau, Bernard
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Cerithiopsidae
Dizoniopsis

description: Genus Dizoniopsis Sacco, 1895
Type species. Cerithium bilineatum Ho ̈rnes, 1848 (Sacco, 1895: 67), by original designation. Middle Miocene, Vienna Basin.
description: Published as part of Sacchetti, Claudia, Landau, Bernard & Ávila, Sérgio P., 2023, The Lower Pliocene marine gastropods of Santa Maria Island, Azores: Taxonomy and palaeobiogeographic implications, pp. 1-150 in Zootaxa 5295 (1) on page 42, DOI: 10.11646/zootaxa.5295.1.1, http://zenodo.org/record/7965273
Centaurea foveolata Blakelock
Creators: name: Negaresh, Kazem
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Asterales
Asteraceae
Centaurea
Centaurea foveolata

description: Centaurea foveolata Blakelock
(Fig. 1)
Kew Bulletin 4 (1): 46 (1949).
TYPE. — Iraq. Amadia, Kurdistan, Mazurka Gorge above Sulaf, 1500 m, 2.VIII.1933, E. R. Guest 3773 (lecto-, first-step designated by Wagenitz [1980: 341] K!; second-step lecto-, designated here, K [K000794077]!; isolecto-, K [K000794076]!).
REMARKS
Blakelock (1949) described Centaurea faveolata based on collections of Guest 3773 from Mazurka, Amadia, but did not mention any specific sheet as the holotype nor the name of the herbarium where the specimens were housed. Two herbarium specimens of collection number 3773 of Guest from Mazurka were found at herbarium K (K000794076 and K000794077). Although Wagenitz (1980) indicated that the lectotype (as “type K”) is at K, he did not specify nor annotate any of the two sheets there, and a second-step lectotypification is needed. The sheetK000794077 is selected here as the lectotype, because it clearly shows the characters mentioned in the protologue.
description: Published as part of Negaresh, Kazem, 2020, Typification of three Iraqi endemic taxa of Centaurea L. (Asteraceae, Cardueae), pp. 255-260 in Adansonia (3) (3) 42 (15) on page 256, DOI: 10.5252/adansonia2020v42a15, http://zenodo.org/record/4447973
Dizoniopsis bilineata
Creators: name: Sacchetti, Claudia
name: Landau, Bernard
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Cerithiopsidae
Dizoniopsis
Dizoniopsis bilineata

description: Dizoniopsis bilineata (Hörnes, 1848)
* Cerithium bilineatum Ho ̈rnes 1848: 21.
Cerithiopsis trilineata [sic] Haern. [sic]— Mayer 1864: 66.
Cerithiopsis (Dizoniopsis) bilineata Ho ̈rnes, 1856 [sic]— Brébion 1964: 247.
Cerithiopsis (s. lat.) bilineata (Hörnes, 1848)—Landau et al. 2006: 14, text-fig. 1, figs. 1-3.
Dizoniopsis bilineata (Hörnes, 1848)— Chirli 2009: 14, pl. 7, figs. 1-12.
Dizoniopsis bilineata (Hörnes, 1848)— Landau et al. 2018: 237, pl. 62, figs. 1-2 (cum syn.).
non Cerithiopsis (Dizoniopsis) bilineata (Hörnes)— Nordsieck 1968: 70, pl. 11, fig. 43.10 [= Dizoniopsis coppolae (Aradas, 1870)].
non Cerithiopsis (Dizoniopsis) bilineata (Hörnes, 1856 [sic])— Nordsieck 1976: 7, fig. 12: 18, unnumbered fig. [= Dizoniopsis concatenata (Conti, 1864)].
? non Dizoniopsis bilineata (Hörnes, 1848)—Gründel 1980: 229, figs. 14-15 [= Dizoniopsis coppolae (Aradas, 1870)].
non Dizoniopsis bilineata (Hörnes, 1848)— Giannuzzi-Savelli et al. 1999: 44, fig. 76 [= Dizoniopsis concatenata (Conti, 1864)].
Santa Maria material examined. One specimen, size not indicated, from Feteirinhas (= Ponta das Salinas), Santa Maria Island, Azores, Touril Complex, Lower Pliocene.
Discussion. Mayer (1864: 66) recorded one specimen as Cerithiopsis bilineata Ĥrnes, 1848 from Feteirinhas (= Ponta das Salinas), but in the text wrote trilineata instead of bilineata (lapsus). Seila trilineata (Philippi, 1836) was also recorded from Santa Maria Island by Mayer (1864: 67), but from the Pleistocene deposits of Praia and Prainha.
Cerithium bilineatum Ho ̈rnes, 1848 is the type species for Dizoniopsis Sacco, 1895, which is characterised by having only two spiral cords on spire whorls instead of three in Cerithiopsis. To be certain of the species, the protoconch must be preserved. No further specimens are available; however, we accept this determination as D. bilineata is widespread in the European Miocene and Pliocene.
Distribution. Middle Miocene: Paratethys, Austria (Hörnes 1848; Landau et al. 2006). Upper Miocene:Atlantic (Tortonian), NW France (Brébion 1964; Landau et al. 2018). Lower Pliocene: Atlantic, Santa Maria Island, Azores (Mayer 1864); Mediterranean, Italy (Chirli 2009). Upper Pliocene: western Mediterranean, Estepona Basin, Spain (Landau et al. 2006).
description: Published as part of Sacchetti, Claudia, Landau, Bernard & Ávila, Sérgio P., 2023, The Lower Pliocene marine gastropods of Santa Maria Island, Azores: Taxonomy and palaeobiogeographic implications, pp. 1-150 in Zootaxa 5295 (1) on pages 42-43, DOI: 10.11646/zootaxa.5295.1.1, http://zenodo.org/record/7965273
Bioinspired Spatiotemporal Management toward RNA Therapies
Creators: name: Li, Shiyao
name: Ma, Yutian
name: Chen, Yupeng
name: Lin, Xin
Publisher: name: The University of North Carolina at Chapel Hill University Libraries
Year: 2023

description: Ribonucleic acid (RNA)-based therapies have become an attractive topic in disease intervention, especially with some that have been approved by the FDA such as the mRNA COVID-19 vaccine (Comirnaty, Pfizer-BioNTech, and Spikevax, Moderna) and Patisiran (siRNA-based drug for liver delivery). However, extensive applications are still facing challenges in delivering highly negatively charged RNA to the targeted site. Therapeutic delivery strategies including RNA modifications, RNA conjugates, and RNA polyplexes and delivery platforms such as viral vectors, nanoparticle-based delivery platforms, and hydrogel-based delivery platforms as potential nucleic acid-releasing depots have been developed to enhance their cellular uptake and protect nucleic acid from being degraded by immune systems. Here, we review the growing number of viral vectors, nanoparticles, and hydrogel-based RNA delivery systems; describe RNA loading/release mechanism induced by environmental stimulations including light, heat, pH, or enzyme; discuss their physical or chemical interactions; and summarize the RNA therapeutics release period (temporal) and their target cells/organs (spatial). Finally, we describe current concerns, highlight current challenges and future perspectives of RNA-based delivery systems, and provide some possible research areas that provide opportunities for clinical translation of RNA delivery carriers.
Centaurea fusiformis Blakelock, Guest 1589
Creators: name: Negaresh, Kazem
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Asterales
Asteraceae
Centaurea
Centaurea fusiformis

description: Centaurea fusiformis Blakelock
(Fig. 2)
Kew Bulletin 4 (1): 47 (1949).
TYPE. — Iraq. Kurdistan, Dohuk [Duhok], Rustam, 450 m, 10.X.1931, E. R. Guest 1589 (lecto-, first-step designated byWagenitz [2006: 349] K!; second-step lecto-, designated here, K [K000794106]!; isolecto-, K [K000794107]!).
REMARKS
Blakelock (1949) in the protologue of Centaurea fusiformis cited “ Iraq, Dohuk, 450 m, 10.X.31, E. R. Guest 1589 (type)”. In Flora Iranica, Wagenitz (1980) cited “type: Guest 1589, K, fragm.W!”. There is no specimen of Centaurea in Guest’s collection at W. Wagenitz (2006) cited “Type: Kurdistan, Dohuk, 1500 fr., 10.X.1931, Guest 1589 (K)”. Pertaining to the type specification provided in the protologue, two specimens of Guest 1589 were traced at K (K000794106 and K000794107). As there is no evidence that Blakelock used only one specimen for describing the species, the type citation by Wagenitz (2006) has to be accepted as the first-step lectotype as it cannot be ascertained which of the specimens at K was selected by him as lectotype. Thus a second-step lectotype has to be designated followingTurland et al. (2018: art. 9.15). The best one and better preserved sheet, K000794106, is designated here as the lectotype, because it is in better condition than another specimen and shows all relevant characters with the protologue.
description: Published as part of Negaresh, Kazem, 2020, Typification of three Iraqi endemic taxa of Centaurea L. (Asteraceae, Cardueae), pp. 255-260 in Adansonia (3) (3) 42 (15) on page 256, DOI: 10.5252/adansonia2020v42a15, http://zenodo.org/record/4447973
Petaloconchus H. C. Lea 1843
Creators: name: Sacchetti, Claudia
name: Landau, Bernard
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Littorinimorpha
Vermetidae
Petaloconchus

description: Genus Petaloconchus H.C. Lea, 1843
Type species. Petaloconchus sculpturatus H.C. Lea, 1845 (H.C. Lea, 1843: 162), by monotypy. Miocene, Virginia, USA.
description: Published as part of Sacchetti, Claudia, Landau, Bernard & Ávila, Sérgio P., 2023, The Lower Pliocene marine gastropods of Santa Maria Island, Azores: Taxonomy and palaeobiogeographic implications, pp. 1-150 in Zootaxa 5295 (1) on page 43, DOI: 10.11646/zootaxa.5295.1.1, http://zenodo.org/record/7965273
Room‐Temperature Formate Ester Transfer Hydrogenation Enables an Electrochemical/Thermal Organometallic Cascade for Methanol Synthesis from CO2
Creators: name: Curley, Julia B.
name: Hazari, Nilay
name: Travis, Benjamin D.
name: Assaf, Eric A.
name: Ahmad, Shahbaz
name: Ertem, Mehmed Z.
name: Miller, Alexander James Minden
name: Fernández, Sergio
Publisher: name: Wiley
Year: 2024

description:
The reduction of CO2 to synthetic fuels is a valuable strategy for energy storage. However, the formation of energy‐dense liquid fuels such as methanol remains rare, particularly under low‐temperature and ‐pressure conditions that can be coupled to renewable electricity sources via electrochemistry. Here, a multicatalyst system pairing an electrocatalyst with a thermal organometallic catalyst is introduced, which enables the reduction of CO2 to methanol at ambient temperature and pressure. The cascade methanol synthesis proceeds via CO2 reduction to formate by electrocatalyst [Cp*Ir(bpy)Cl]+ (Cp* = pentamethylcyclopentadienyl, bpy = 2,2’‐bipyridine), Fischer esterification of formate to isopropyl formate catalyzed by trifluoromethanesulfonic acid (HOTf), and thermal transfer hydrogenation of isopropyl formate to methanol facilitated by the organometallic catalyst (H‐PNP)Ir(H)3 (H‐PNP = HN(C2H4PiPr2)2). The isopropanol solvent plays several crucial roles: activating formate ion as isopropyl formate, donating hydrogen for the reduction of formate ester to methanol via transfer hydrogenation, and lowering the barrier for transfer hydrogenation through hydrogen bonding interactions. In addition to reporting a method for room‐temperature reduction of challenging ester substrates, this work provides a prototype for pairing electrochemical and thermal organometallic reactions that will guide the design and development of multicatalyst cascades.
Centaurea longipedunculata Boiss.
Creators: name: Negaresh, Kazem
Publisher: name: Zenodo
Year: 2020
Subjects: Biodiversity
Taxonomy
Plantae
Tracheophyta
Magnoliopsida
Asterales
Asteraceae
Centaurea
Centaurea longipedunculata

description: Centaurea longipedunculata Sch. Bip. ex Boiss.
(Fig. 3)
Flora Orientalis 3: 668 (1875) “ longepedunculata ”. — Colymbada longipedunculata (Boiss.) Holub, Folia Geobotanica et Phytotaxonomica 7: 316 (1972).
LECTOTYPE (DESIGNATED HERE). — Iraq. In proclivibus orientem versus sitis pr. pagum Gara Kurdist. [Assyricae supra Mossul], 5.VIII.1841, Th. Kotschy, Pl. Alepp. Kurd.374 (lecto-, P [P02585330]!; isolecto-, FI [FI 006606!, FI 012678]!, GOET [GOET001278]!, HAL [HAL0112768]!, H [H1034886]!, JE [JE00015706]!, K [K000794200, K000794201, K000794202]!, M [M0030573]!, P [P00730220, P00730221, P00730222, P00730223, P00730224, P02585331]!, S [S10-6688]!, US [US00289164]!, W [W1889- 0065801, W1889-0294071, W0056442, W0056443, W0056444, W0056445], WAG [WAG0004184]!).
REMARKS
Twenty-six duplicates of the type of Centaurea longipedunculata were found at FI, GOET, HAL, H, JE, K, M, P, S, US, W and WAG, which had to be treated as syntypes (Art. 40, Note 1 of the International Code of Nomenclature; Turland et al. 2018). According to McNeill (2014), the existence of a holotype cannot be established in this case, as there were more than one specimen for this species, housed in more than one institution. P00730226, P02585330, HAL0112768 and W0056442 show the roots and therefore the perennial habit. The specimen P00730226 is not suitable as lectotype because it has a handwritten label with a wrong number “74”, though it is probably from the same collection. HAL0112768 is fragmentary. W0056442 does not show the leaves very well. But most of the syntypes are even worse or has also as annotation the field book number of Kotschy “451”. The sheet P02585330 is better preserved and more complete than the other duplicates and best represents the species description given in the protologue; hence, it is designated here as the lectotype.
description: Published as part of Negaresh, Kazem, 2020, Typification of three Iraqi endemic taxa of Centaurea L. (Asteraceae, Cardueae), pp. 255-260 in Adansonia (3) (3) 42 (15) on page 256, DOI: 10.5252/adansonia2020v42a15, http://zenodo.org/record/4447973
Cell-free DNA Screening and Maternal Cancer
Creators: name: Vora, Neeta L.
Publisher: name: Massachusetts Medical Society
Year: 2024

description:
In 2013, I, along with other investigators, described a healthy woman with an uncomplicated pregnancy who was referred to maternal fetal medicine and genetic counseling because she received positive results for trisomy 13 and monosomy 18 through a screening assay of cell-free DNA (cfDNA) obtained from a blood sample.
Subtyping of mild cognitive impairment using a deep learning model based on brain atrophy patterns
Creators: name: Kwak, K
name: Dayan, E
name: Styner, M
name: Alzheimer's Disease Neuroimaging Initiative
name: Bozoki, A
name: Giovanello, K.S
Publisher: name: Cell Press
Year: 2021

description: Trajectories of cognitive decline vary considerably among individuals with mild cognitive impairment (MCI). To address this heterogeneity, subtyping approaches have been developed, with the objective of identifying more homogeneous subgroups. To date, subtyping of MCI has been based primarily on cognitive measures, often resulting in indistinct boundaries between subgroups and limited validity. Here, we introduce a subtyping method for MCI based solely upon brain atrophy. We train a deep learning model to differentiate between Alzheimer's disease (AD) and cognitively normal (CN) subjects based on whole-brain MRI features. We then deploy the trained model to classify MCI subjects based on whole-brain gray matter resemblance to AD-like or CN-like patterns. We subsequently validate the subtyping approach using cognitive, clinical, fluid biomarker, and molecular imaging data. Overall, the results suggest that atrophy patterns in MCI are sufficiently heterogeneous and can thus be used to subtype individuals into biologically and clinically meaningful subgroups.
Bodily awareness: Religious culture’s associations with interoceptive sensibility
Creators: name: Van Cappellen, Patty
name: Drummond, Tehya M. LePage
Publisher: name: Public Library of Science (PLoS)
Year: 2024

description:
Religions, as cultural systems, influence how people view and attune to their body. This research explores whether individual differences in various dimensions of religiosity are associated with interoceptive sensibility (IS), i.e., one's perceived ability to detect and interpret bodily signals. In Study 1, Christians, Muslims, and Hindus (N = 1570) reported their religiosity and completed the Multidimensional Assessment of Interoceptive Awareness, a well-validated measure of IS. Results show that religious identity moderates the relationship between the centrality of religion in one's life and IS such that the association is positive and medium for Christians, large for Muslims and Hindus. In addition, the medium positive correlation between frequency of religious practice and IS was similar across religious groups. Study 2 (N = 450) extended these results by measuring additional dimensions of religiosity and spirituality as well as investigating religious-related beliefs about the body, both positive (e.g., My body is holy) and negative (e.g., My body is sinful). Associations between religiosity and IS are replicated and found for spirituality as well. Interestingly, mediation analyses reveal that belief in the body as holy partially explains the association between religiosity and IS, but belief in the body as sinful suppresses such association. We discuss how religion, as a cultural factor, may influence beliefs about the body and bodily awareness, with implications for emotion regulation and mental health.
Saltipedis Gutu 1995
Creators: name: Hansknecht, Tom
name: Heard, Richard W.
name: Martin, Joel W.
Publisher: name: Zenodo
Year: 2001
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Malacostraca
Tanaidacea
Parapseudidae
Saltipedis

description: Saltipedis Gu ‰ u, 1995
Diagnosis. (Modified, 1996). Apseudomorpha, Parapseudidae. Eyes and carapace without spinous processes. Coxa of pereopod 2 lacking spine or spinose process. 1st hyposphenial spine laterally flattened, curved and directed anteriorly over mouthpart bundle. Oostegites, 5 pairs. Pereopods 5­7 with basis greatly enlarged. Anterior (= tergal) margin of basis of pereopod 7 lined with plumose setae. Pleonite 1 with dorsal margin bearing transverse row of small setae. Pleopods, 5 pairs.
description: Published as part of Hansknecht, Tom, Heard, Richard W. & Martin, Joel W., 2001, Saltipedis navassensis, a new species of apseudomorph tanaidacean (Crustacea: Peracarida: Parapseudidae) from the tropical northwestern Atlantic, pp. 1-11 in Zootaxa 18 on page 2, DOI: 10.5281/zenodo.4618328
Direct-to-consumer tests: emerging trends are cause for concern.
Creators: name: Woloshin, Steven
name: Plüddemann, Annette
name: Shih, Patti
name: Ransohoff, David F
name: Gram, Emma Grundtvig
name: Kramer, Barnett S
name: Copp, Tessa
Publisher: name: BMJ
Year: 2024

description:
Advances in diagnostic technology and digital health have increased the variety and volume of direct-to-consumer tests—commercial tests initiated by consumers without clinical consultation. Sales of these tests have surged from $15m in 2010 to $1.15bn in 2022 in the United States alone. As well as the better known DTC tests for covid-19, genetics, and HIV, many other types of tests are now available, including for prostate health checks, thyroid function, and food sensitivity. However, no dedicated regulatory framework exists to govern the appropriate use of emerging DTC products.
Comparative transcriptomic, epigenomic and immunological analyses identify drivers of disparity in high-grade serous ovarian cancer
Creators: name: Lengyel, Ernst
name: Kocherginsky, Masha
name: Cardenas, Horacio
name: Zhao, Guangyuan
name: Barber, Emma L.
name: Nephew, Kenneth P.
name: Bae-Jump, Victoria
name: Zhang, Bin
name: Huang, Hao
name: Wei, Jianjun
name: Fu, Zhen
name: Xie, Ping
name: Matei, Daniela
name: Kim, Ujin
name: Keathley, Russel
Publisher: name: Springer Nature
Year: 2024

description:
Black women face the highest mortality-to-incidence ratio from high grade serous ovarian cancer (HGSOC). This study investigated biological differences in HGSOC tumors from Black vs. White women. HGSOC from 35 Black and 31 White patients were analyzed by Infinium Methyation-EPIC array and RNA sequencing. 191 CpG sites were differentially methylated (FDR < 0.05, β value change> 10%) and 277 genes were differentially expressed (FDR < 0.05). Gene Ontology identified enriched pathways related to DNA damage response, p53/apoptosis signaling, and cholesterol/lipid metabolism directly connected with genes like INSR, FOXA1 and FOXB1. INSR and FOXA1 knockdown enhanced cisplatin sensitivity and inhibited cell proliferation and colony formation. Tumors from Black patients were infiltrated by fewer CD4+ naïve and regulatory T-cells. Overall, differences in DNA methylation, transcriptomic profiles and immune cell infiltration were detected in tumors from Black vs. White patients. Further investigation is warranted into how these differences may affect treatment response and outcomes in Black women.
Subversion of Serotonin Receptor Signaling in Osteoblasts by Kynurenine Drives Acute Myeloid Leukemia
Creators: name: Ali, A.M
name: Gil-Iturbe, E
name: Galán-Díez, M
name: Borot, F
name: Roth, B.L
name: Raza, A
name: Luo, N
name: Liu, Y
name: Kousteni, S
name: Mukherjee, S
name: Carroll, M
name: Bisikirska, B
name: Kurland, I
name: Zhao, J
name: Shan, X
name: Quick, M
name: Rabadán, R
name: Huang, X.-P
name: Labella, R
Publisher: name: American Association for Cancer Research Inc.
Year: 2022

description: Remodeling of the microenvironment by tumor cells can activate pathways that favor cancer growth. Molecular delineation and targeting of such malignant-cell nonautonomous pathways may help overcome resistance to targeted therapies. Herein we leverage genetic mouse models, patient-derived xenografts, and patient samples to show that acute myeloid leukemia (AML) exploits peripheral serotonin signaling to remodel the endosteal niche to its advantage. AML progression requires the presence of serotonin receptor 1B (HTR1B) in osteoblasts and is driven by AMLsecreted kynurenine, which acts as an oncometabolite and HTR1B ligand. AML cells utilize kynurenine to induce a proinflammatory state in osteoblasts that, through the acute-phase protein serum amyloid A (SAA), acts in a positive feedback loop on leukemia cells by increasing expression of IDO1—the ratelimiting enzyme for kynurenine synthesis—thereby enabling AML progression. This leukemia–osteoblast cross-talk, conferred by the kynurenine–HTR1B–SAA–IDO1 axis, could be exploited as a niche-focused therapeutic approach against AML, opening new avenues for cancer treatment. SIGNIFICANCE: AML remains recalcitrant to treatments due to the emergence of resistant clones. We show a leukemia-cell nonautonomous progression mechanism that involves activation of a kynurenine– HTR1B–SAA–IDO1 axis between AML cells and osteoblasts. Targeting the niche by interrupting this axis can be pharmacologically harnessed to hamper AML progression and overcome therapy resistance.
Inferring the proportion of undetected cholera infections from serological and clinical surveillance in an immunologically naive population
Creators: name: Jackson, Brendan
name: Mintz, Eric
name: Lemaitre, Joseph
name: Lessler, Justin
name: Finger, Flavio
name: Juin, Stanley
name: Dely, Patrick
name: Funk, Sebastian
name: Azman, Andrew S
name: Boncy, Jacques
Publisher: name: Cambridge University Press (CUP)
Year: 2024

description:
Most infections with pandemic Vibrio cholerae are thought to result in subclinical disease and are not captured by surveillance. Previous estimates of the ratio of infections to clinical cases have varied widely (2 to 100 infections per case). Understanding cholera epidemiology and immunity relies on the ability to translate between numbers of clinical cases and the underlying number of infections in the population. We estimated the infection incidence during the first months of an outbreak in a cholera-naive population using a Bayesian vibriocidal antibody titer decay model combining measurements from a representative serosurvey and clinical surveillance data. 3,880 suspected cases were reported in Grande Saline, Haiti, between 20 October 2010 and 6 April 2011 (clinical attack rate 18.4%). We found that more than 52.6% (95% Credible Interval (CrI) 49.4-55.7) of the population ≥2 years showed serologic evidence of infection, with a lower infection rate among children aged 2-4 years (35.5%; 95%CrI 24.2-51.6) compared with people ≥5 years (53.1%; 95%CrI 49.4-56.4). This estimated infection rate, nearly three times the clinical attack rate, with underdetection mainly seen in those ≥5 years, has likely impacted subsequent outbreak dynamics. Our findings show how seroincidence estimates improve understanding of links between cholera burden, transmission dynamics and immunity.
Thylacodes Guettard 1770
Creators: name: Sacchetti, Claudia
name: Landau, Bernard
name: Ávila, Sérgio P.
Publisher: name: Zenodo
Year: 2023
Subjects: Biodiversity
Taxonomy
Animalia
Mollusca
Gastropoda
Littorinimorpha
Vermetidae
Thylacodes

description: Genus Thylacodes Guettard, 1770
Type species. Serpulorbis polyphragma Sassi, 1827 (Guettard 1770: 143), by subsequent designation (Keen 1961). Present-day, Mediterranean.
description: Published as part of Sacchetti, Claudia, Landau, Bernard & Ávila, Sérgio P., 2023, The Lower Pliocene marine gastropods of Santa Maria Island, Azores: Taxonomy and palaeobiogeographic implications, pp. 1-150 in Zootaxa 5295 (1) on page 45, DOI: 10.11646/zootaxa.5295.1.1, http://zenodo.org/record/7965273
Sugar-sweetened beverage (SSB) consumption is associated with lower quality of the non-SSB diet in US adolescents and young adults
Creators: name: Popkin B.M
name: Lacko A.M
name: Doherty A.M
Publisher: name: Oxford University Press
Year: 2021

description: Background: Since 2003-4, the United States has seen large declines in sugar-sweetened beverage (SSB) intake overall, especially among non-Hispanic white (NHW) subpopulations. However, obesity prevalence has not shown comparable declines in the 2 highest SSB-consuming groups, adolescents and young adults. Little is understood about the quality of the diet excluding SSBs (non-SSB diet). Objectives: The objective of this study was to evaluate differences in non-SSB diet quality in SSB consumers and nonconsumers in adolescents and young adults and in the 3 major race/ethnic subgroups. Methods: This study utilized data from the NHANES, a cross-sectional, nationally representative survey of the US population. Data from 6426 participants aged 12-29 y from the NHANES (2009-2014) was included. Quality of the non-SSB diet was measured using the 2015 Healthy Eating Index (HEI). Multivariate linear regressions controlled for sociodemographic characteristics and included interactions by race/ethnicity [NHWs, non-Hispanic blacks (NHBs), Hispanics]. Individuals were classified as non-, low-(<10% of daily calories), or high-SSB consumers (≥10% of daily calories), according to the US Dietary Guidelines added sugar intake recommendation. Results: Non-SSB HEI scores differed among SSB consumer groups (53 for adolescent nonconsumers compared with 46 for high consumers, P < 0.001; 57 for young adult nonconsumers compared with 45 for high consumers, P < 0.001), although all scores were low and require improvement. Among NHBs, significant differences in non-SSB HEI were found only between non-And low-SSB consumers. In Hispanics, associations varied by age group, with significant differences found for young adults but no association found for adolescents. Conclusions: Low non-SSB HEI scores in SSB consumers suggest that reducing SSB consumption alone will not be a sufficient strategy for improving dietary quality in adolescents and young adults. Future policies must also consider improving the non-SSB diet.
Schoengastiella (Schoengastiella) absonata Nadchatram and Fernandes 1989
Creators: name: Nielsen, David H.
name: Robbins, Richard G.
name: Rueda, Leopoldo M.
Publisher: name: Zenodo
Year: 2021
Subjects: Biodiversity
Taxonomy
Animalia
Arthropoda
Arachnida
Actinedida
Walchiidae
Schoengastiella
Schoengastiella absonata

description: Schoengastiella (Schoengastiella) absonata Nadchatram and Fernandes, 1989
: PAL
description: Published as part of Nielsen, David H., Robbins, Richard G. & Rueda, Leopoldo M., 2021, Annotated world checklist of the Trombiculidae and Leeuwenhoekiidae (1758 - 2021) (Acari: Trombiculoidea), with notes on nomenclature, taxonomy, and distribution, pp. 1-243 in Zootaxa 4967 (1) on page 31, DOI: 10.11646/zootaxa.4967.1.1, http://zenodo.org/record/4745510