cometadata/datacite-rtg-text-other-reclassification-records huggingface dataset:
MDH1 and MPP7 regulate autophagy in pancreatic ductal adenocarcinoma
Creators: name: New, Maria
name: Acker, Tim Van
name: Jun-Ichi Sakamaki
name: Jiang, Ming
name: Saunders, Rebecca E
name: Long, Jaclyn
name: Wang, Victoria MY
name: Behrens, Axel
name: Cerveira, Joana
name: Padhmanand Sudhakar
name: Korcsmaros, Tamas
name: Jefferies, Harold BJ
name: Ryan, Kevin M
name: Howell, Michael
name: Tooze, Sharon A
Publisher: name: The Francis Crick Institute
Year: 2019
Subjects: Model organisms
Biochemistry & Proteomics
Imaging
Tumour Biology
Signalling & Oncogenes
Gene Expression
Genetics & Genomics
Genome Integrity & Repair
Cell Biology
Stem Cells
Chemical Biology & High Throughput

description: Pancreatic ductal adenocarcinoma (PDAC) is driven by metabolic changes in pancreatic cells caused by oncogenic mutations and dysregulation of p53. PDAC cell lines and PDAC-derived xenografts grow as a result of altered metabolic pathways, changes in stroma, and autophagy. Selective targeting and inhibition of one of these may open avenues for the development of new therapeutic strategies. In this study, we performed a genome-wide siRNA screen in a PDAC cell line using endogenous autophagy as a readout and identified several regulators of autophagy that were required for autophagy-dependent PDAC cell survival. Validation of two promising candidates, MPP7 (MAGUK p55 subfamily member 7, a scaffolding protein involved in cell-cell contacts) and MDH1 (cytosolic Malate dehydrogenase 1), revealed their role in early stages of autophagy during autophagosome formation. MPP7 was involved in the activation of YAP1 (a transcriptional coactivator in the Hippo pathway), which in turn promoted autophagy, whereas MDH1 was required for maintenance of the levels of the essential autophagy initiator serine-threonine kinase ULK1, and increased in the activity upon induction of autophagy. Our results provide a possible explanation for how autophagy is regulated by MPP7 and MDH1, which adds to our understanding of autophagy regulation in PDAC. SIGNIFICANCE: This study identifies and characterizes MPP7 and MDH1 as novel regulators of autophagy, which is thought to be responsible for pancreatic cancer cell survival.
An empirical comparison of spatial scan statistics for outbreak detection.
Creators: name: Neill, Daniel B.
Publisher: name: Carnegie Mellon University
Year: 2009
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences
subject: 160510 Public Policy
subject: FOS: Political science

description: BACKGROUND: The spatial scan statistic is a widely used statistical method for the automatic detection of disease clusters from syndromic data. Recent work in the disease surveillance community has proposed many variants of Kulldorff's original spatial scan statistic, including expectation-based Poisson and Gaussian statistics, and incorporates a variety of time series analysis methods to obtain expected counts. We evaluate the detection performance of twelve variants of spatial scan, using synthetic outbreaks injected into four real-world public health datasets. RESULTS: The relative performance of methods varies substantially depending on the size of the injected outbreak, the average daily count of the background data, and whether seasonal and day-of-week trends are present. The expectation-based Poisson (EBP) method achieves high performance across a wide range of datasets and outbreak sizes, making it useful in typical detection scenarios where the outbreak characteristics are not known. Kulldorff's statistic outperforms EBP for small outbreaks in datasets with high average daily counts, but has extremely poor detection power for outbreaks affecting more than of the monitored locations. Randomization testing did not improve detection power for the four datasets considered, is computationally expensive, and can lead to high false positive rates. CONCLUSION: Our results suggest four main conclusions. First, spatial scan methods should be evaluated for a variety of different datasets and outbreak characteristics, since focusing only on a single scenario may give a misleading picture of which methods perform best. Second, we recommend the use of the expectation-based Poisson statistic rather than the traditional Kulldorff statistic when large outbreaks are of potential interest, or when average daily counts are low. Third, adjusting for seasonal and day-of-week trends can significantly improve performance in datasets where these trends are present. Finally, we recommend discontinuing the use of randomization testing in the spatial scan framework when sufficient historical data is available for empirical calibration of likelihood ratio scores.
AT2017gfo: an anisotropic and three-component kilonova counterpart of GW170817
Creators: name: Perego, Albino
name: Radice, David
name: Bernuzzi, Sebastiano
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: The detection of a kilo/macronova electromagnetic counterpart (AT2017gfo) of the first gravitational wave signal compatible with the merger of two neutron stars (GW170817) has confirmed the occurrence of r-process nucleosynthesis in this kind of events. The blue and red components of AT2017gfo have been interpreted as the signature of multi-component ejecta in the merger dynamics. However, the explanation of AT2017gfo in terms of the properties of the ejecta and of the ejection mechanisms is still incomplete. In this work, we analyse AT2017gfo with a new semi-analytic model of kilo/macronova inferred from general relativistic simulations of the merger and long-term numerical models of the merger aftermath. The model accounts for the anisotropic emission from the three known mass ejecta components: dynamic, winds and secular outflows from the disk. The early multi-band light-curves of AT2017gfo can only be explained by the presence of a relatively low opacity component of the ejecta at high latitudes. This points to the key role of weak interactions in setting the ejecta properties and determining the nucleosynthetic yields. Our model constrains also the total ejected mass associated to AT2017gfo to be between $0.042$ and $0.077 M_{\odot}$; the observation angle of the source to be between $π/12$ and $7π/36 $; and the mass of the disk to be $ \gtrsim 0.08 M_{\odot}$.
description: 9 pages, 4 figures and one table. Submitted to ApJL
Detection of influenza C virus infection among hospitalized patients, Cameroon
Creators: name: Njouom, Richard
name: Monamele, Gwladys Chavely
name: Ermetal, Burcu
name: Tchatchouang, Serge
name: Moyo-Tetang, Sylvie
name: McCauley, John W
name: Daniels, Rodney S
Publisher: name: The Francis Crick Institute
Year: 2019
Subjects: Infectious Disease
Ecology,Evolution & Ethology

description: We report 3 cases of influenza C virus in children hospitalized with severe acute respiratory infection in Cameroon. Two of these case-patients had grave clinical manifestations, but all 3 recovered. The lack of specific antiviral drugs for influenza C virus highlights the need to identify and describe cases involving this virus.
СОВРЕМЕННЫЕ ПОДХОДЫ К ИСПОЛЬЗОВАНИЮ ФИТОПРЕПАРАТОВ В КОМПЛЕКСНОМ ЛЕЧЕНИИ ТУБЕРКУЛЕЗА
Creators: name: Ташпулатова, Фатима
name: Алиджанов, Сарвар
name: Сабиров, Шавкат
Publisher: name: Zenodo
Year: 2024

description: Туберкулез (ТБ) остается серьезной глобальной проблемой здравоохранения, при этом потребность в инновационных и эффективных стратегиях лечения становится более острой, чем когда-либо. На этом фоне фитотерапия становится многообещающим дополнением к комплексному лечению туберкулеза, предлагая потенциальные преимущества, варьирующиеся от повышения эффективности лекарств до облегчения побочных эффектов, связанных с традиционным лечением туберкулеза. В этой статье рассматриваются современные подходы к интеграции фитотерапии в схемы лечения туберкулеза, исследуются научные данные об эффективности и безопасности различных растительных лекарственных средств.
Generalized Solutions for Quantum Mechanical Oscillator on Kähler Conifold
Creators: name: Giri, Pulak Ranjan
Publisher: name: arXiv
Year: 2006
Subjects: subject: High Energy Physics - Theory (hep-th)
subject: FOS: Physical sciences

description: We study the possible generalized boundary conditions and the corresponding solutions for the quantum mechanical oscillator model on Kähler conifold. We perform it by self-adjoint extension of the the initial domain of the effective radial Hamiltonian. Remarkable effect of this generalized boundary condition is that at certain boundary condition the orbital angular momentum degeneracy is restored! We also recover the known spectrum in our formulation, which of course correspond to some other boundary condition.
description: 7 pages, latex, no figure
Kinematics of Parsec-Scale Jets of Gamma-Ray Blazars at 43~GHz within the VLBA-BU-BLAZAR Program
Creators: name: Jorstad, Svetlana G.
name: Marscher, Alan P.
name: Morozova, Daria A.
name: Troitsky, Ivan S.
name: Agudo, Iván
name: Casadio, Carolina
name: Foord, Adi
name: Gómez, José L.
name: MacDonald, Nicholas R.
name: Molina, Sol N.
name: Lähteenmäki, Anne
name: Tammi, Joni
name: Tornikoski, Merja
Publisher: name: arXiv
Year: 2017
Subjects: subject: Astrophysics of Galaxies (astro-ph.GA)
subject: High Energy Astrophysical Phenomena (astro-ph.HE)
subject: FOS: Physical sciences

description: We analyze the parsec-scale jet kinematics from 2007 June to 2013 January of a sample of $γ$-ray bright blazars monitored roughly monthly with the Very Long Baseline Array at 43~GHz. In a total of 1929 images, we measure apparent speeds of 252 emission knots in 21 quasars, 12 BL~Lacertae objects (BLLacs), and 3 radio galaxies, ranging from 0.02$c$ to 78$c$; 21\% of the knots are quasi-stationary. Approximately 1/3 of the moving knots execute non-ballistic motions, with the quasars exhibiting acceleration along the jet within 5~pc (projected) of the core, and knots in the BLLacs tending to decelerate near the core. Using apparent speeds of components and timescales of variability from their light curves, we derive physical parameters of 120 superluminal knots, including variability Doppler factors, Lorentz factors, and viewing angles. We estimate the half-opening angle of each jet based on the projected opening angle and scatter of intrinsic viewing angles of knots. We determine characteristic values of physical parameters for each jet and AGN class based on the range of values obtained for individual features. We calculate intrinsic brightness temperatures of the cores, $T_{\rm b,int}^{\rm core}$, at all epochs, finding that the radio galaxies usually maintain equipartition conditions in the cores, while $\sim$30\% of $T_{\rm b,int}^{\rm core}$ measurements in the quasars and BLLacs deviate from equipartition values by a factor $>$10. This probably occurs during transient events connected with active states. In the Appendix we briefly describe the behavior of each blazar during the period analyzed.
description: 48 pages, 18 figures, Tables 2,3,5, & 7 in a full length and figures 2 and 4 for each source can be found in the journal version of the paper
MOESM1 of Influence of heart rate control on exercise capacity and quality of life in patients with permanent atrial fibrillation
Creators: name: She, Fei
name: Ma, Yuan
name: Li, Yi
name: Li, Lei
name: Xu, Weixian
name: Wang, Hongyan
name: Cui, Ming
Publisher: name: figshare
Year: 2019
Subjects: subject: Space Science
subject: Medicine
subject: Pharmacology
subject: Sociology
subject: FOS: Sociology
subject: Biological Sciences not elsewhere classified
subject: Developmental Biology
subject: Mental Health

description: Additional file 1: Table S1. Multivariate Regression Analysis of Resting Heart Rate and PCS. Table S2. Multivariate Regression Analysis of Resting Heart Rate and MCS. Table S3. Multivariate Regression Analysis of Exercise Heart Rate and PCS. Table S4. Multivariate Regression Analysis of Exercise Heart Rate and MCS. Table S5. Pearson correlation between heart rate and SF-36 score item.
INTERNAL CONTROL AND BANK PERFORMANCE: EVIDENCE FROM SELECTED COMMERCIAL BANKS IN NIGERIA
Creators: name: Agbo,, Elias Igwebuike
name: Basilia Chiamaka, Nwachukwu Ph.D.
Publisher: name: ZAP JOURNALS
Year: 2025
Subjects: Internal control system; Bank performance, COSO; Nigeria.

description: Despite the crucial role played by the banking sector in regulating the economy worldwide and the significant failures and crises it has experienced in the past for which t weakness in internal control was responsible, a majority of the studies concerning the connection between internal control and firm performance were carried out employing members from numerous sectors other than the sector. This research examines the effect of the compliance with internal control system on the performance of banks in Nigeria Using the survey research approach, the extent the compliance with internal control system has affected the indicators of performance in banks was examined, Frequency tables and percentages were employed to collate and arrange the views those that responded to the questionnaires distributed. The hypotheses of the study were tested using one sample-test technique. The research had a population of 84, while the size of the sample was 69. The results indicate that internal control system has a strong and positive impact on the performance of deposit-money banks in Nigeria. This suggests that bank management should entrench significant internal control components in their banks to achieve optimal performance
ОСОБЕННОСТИ КЛИНИЧЕСКОГО ТЕЧЕНИЯ, ДИАГНОСТИКИ И ЭФФЕКТИВНОСТИ ЛЕЧЕНИЯ ТУБЕРКУЛЕЗНОГО МЕНИНГИТА У ВИЧ-ИНФИЦИРОВАННЫХ
Creators: name: Ташпулатова, Фатима
name: Алиджанов, Сарвар
name: Сабиров, Шавкат
Publisher: name: Zenodo
Year: 2024

description: Туберкулезный менингит (ТБМ) у ВИЧ-инфицированных пациентов представляет собой уникальные проблемы в клиническом течении, диагностике и эффективности лечения, требующие индивидуального подхода к лечению. В этой статье рассматривается пересечение ТБМ и ВИЧ-инфекции, подчеркивая особенности течения заболевания, трудности диагностики и результаты лечения в этой группе населения. Синергия между ВИЧ и туберкулезом (ТБ) усложняет клиническую картину, часто приводя к атипичным проявлениям ТБМ и более высокому риску неблагоприятных результатов лечения.
title: doute-incrédulité 3 annotation
Creators: name: Mạc, Đăng Khoa
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015
Subjects: subject: Vietnamien
subject: vie

description: Conforms to: Praat textgrid
Nonclassicality and entanglement criteria for bipartite optical fields characterized by quadratic detectors
Creators: name: Perina, Jan
name: Arkhipov, Ievgen I.
name: Michalek, Vaclav
name: Haderka, Ondrej
Publisher: name: arXiv
Year: 2017
Subjects: subject: Quantum Physics (quant-ph)
subject: FOS: Physical sciences

description: Numerous inequalities involving moments of integrated intensities and revealing nonclassicality and entanglement in bipartite optical fields are derived using the majorization theory, non-negative polynomials, the matrix approach, as well as the Cauchy-Schwarz inequality. Different approaches for deriving these inequalities are compared. Using the experimental photocount histogram generated by a weak noisy twin beam monitored by a photon-number-resolving iCCD camera the performance of the derived inequalities is compared. A basic set of ten inequalities suitable for monitoring the entanglement of a twin beam is suggested. Inequalities involving moments of photocounts (photon numbers) as well as those containing directly the elements of photocount (photon-number) distributions are also discussed as a tool for revealing nonclassicality.
description: 15 pages, 19 figures
An Empirical Analysis of the Impact of Pre-Release Movie Piracy on Box-Office Revenue
Creators: name: Liye  Ma
name: Montgomery, Alan
name: Param Singh
name: Smith, Michael
Publisher: name: Carnegie Mellon University
Year: 2014
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences
subject: 160510 Public Policy
subject: FOS: Political science

description: Digital distribution channels raise many new challenges for managers in the media industries. This is particularly true for movie studios where high-value content can be stolen and released through illegitimate digital channels, even prior to the release of the movie in legal channels. In response to this potential threat, movie studios have spent millions of dollars to protect their content from unauthorized distribution throughout the lifecycle of films. They have focused their efforts on the pre-release period under the assumption that pre-release piracy could be particularly harmful for a movie’s success. However, surprisingly, there has been little rigorous research to analyze whether, and how much, pre-release movie piracy diminishes legitimate sales. In this paper, we analyze this question using data collected from a unique Internet file-sharing site. We find that, on average, pre-release piracy causes a 19.1% decrease in revenue compared to piracy that occurs postrelease. Our study contributes to the growing literature on piracy and digital media consumption by presenting evidence of the impact of Internet-based movie piracy on sales, and by analyzing pre-release piracy, a setting that is distinct from much of the extant literature.
A Fully Decentralized Control of Grid-Connected Cascaded Inverters
Creators: name: Sun, Yao
name: Hou, Xiaochao
name: Han, Hua
name: Liu, Zhangjie
name: Yuan, Wenbin
name: Su, Mei
Publisher: name: arXiv
Year: 2017
Subjects: subject: Systems and Control (eess.SY)
subject: FOS: Electrical engineering, electronic engineering, information engineering

description: This letter proposes a decentralized control scheme for grid-connected cascaded modular inverters without any communication, and each module makes decisions based on its own local information. In contrast, the conventional methods are usually centralized control and depend on a real-time communication. Thus, the proposed scheme has advantages of improved reliability and decreased costs. The overall system stability is analyzed, and the stability condition is derived as well. The feasibility of the proposed method is verified by simulation.
description: 2 Pages, 2 figures
An Empirical Analysis of Cellular Voice and Data Services
Creators: name: Telang, Rahul
Publisher: name: Carnegie Mellon University
Year: 2004
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences
subject: 160510 Public Policy
subject: FOS: Political science

description: Cellular telephony and associated data services has been a major social phenomena for well over a decade now. It has changed the way – in some countries more than others – in which people communicate. In many countries in Northern Europe and Asia, its penetration rates are very high and in others less so but in all cases it has engendered change at multiple levels – socially as noted and in terms of market structure and competition with the established Incumbent Local Exchange and Inter Exchange service providers. However, there has been little work published in the academic literature on user consumption of cellular voice and data services. This has been due to the unavailability of longitudinal data at the individual user level on their consumption of voice and data services. We have such data from a large cellular service provider in Asia. Demand for voice and data services is influenced by the tariffs or “service plans” offered by firms. In our analysis we empirically estimate the drivers for cellular services how demographic and plan characteristics affect the user choices. We first provide a theoretical model and then provide insight into consumption patterns over a one year period of cellular voice and data services and relate it to service plan design.
Dynamical susceptibility of a near-critical non-conserved order parameter and B2g Raman response in Fe-based superconductors
Creators: name: Klein, Avraham
name: Lederer, Samuel
name: Chowdhury, Debanjan
name: Berg, Erez
name: Chubukov, Andrey
Publisher: name: arXiv
Year: 2017
Subjects: subject: Strongly Correlated Electrons (cond-mat.str-el)
subject: Superconductivity (cond-mat.supr-con)
subject: FOS: Physical sciences

description: We analyze the dynamical response of a two-dimensional system of itinerant fermions coupled to a scalar boson $ϕ$, which undergoes a continuous transition towards nematic order with $d-$wave form-factor. We consider two cases: (a) when $ϕ$ is a soft collective mode of fermions near a Pomeranchuk instability, and (b) when it is an independent critical degree of freedom, such as a composite spin order parameter near an Ising-nematic transition. In both cases, the order-parameter is not a conserved quantity and the $d-$wave fermionic polarization $Π(q, Ω)$ remains finite even at $q=0$. The polarization $Π(0, Ω)$ has similar behavior in the two cases, but the relations between $Π(0, Ω)$ and the bosonic susceptibility $χ(0, Ω)$ are different, leading to different forms of $χ^{\prime \prime} (0, Ω)$, as measured by Raman scattering. We compare our results with polarization-resolved Raman data for the Fe-based superconductors FeSe$_{1-x}$S$_x$, NaFe$_{1-x}$Co$_x$As and BaFe$_2$As$_2$. We argue that the data for FeSe$_{1-x}$S$_x$ are well described within Pomeranchuk scenario, while the data for NaFe$_{1-x}$Co$_x$As and BaFe$_2$As$_2$ are better described within the "independent" scenario involving a composite spin order.
An Age-Structured Single-State Initiation Model -- Cycles of Drug Epidemics and Optimal Prevention Programs
Creators: name: Almeder, Christian
name: Caulkins, Jonathan
name: Feichtinger, Gustav
name: Tragler, Gernot
Publisher: name: Carnegie Mellon University
Year: 2002
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences
subject: 160510 Public Policy
subject: FOS: Political science

description: This paper introduces a model for drug initiation that extends traditional dynamic models by considering explicitly the age distribution of the users. On the basis of a 2-groups model in which the population in split into a user and a non-user group the advantage of a continuous age distribution is shown by considering more details and by yielding new results. Neglecting death rates reduces the model to a single state (1-group) descriptive model which can still simulate some of the complex behavior of drug epidemics such as repeated cycles. Furthermore, prevention programs - especially school-based programs - can eb targeted to certain age classes. So in order to discover how best to allocate resources to prevention programs over different age classes we formulate and solve optimal control models.
Controllable Asymmetric Phase-Locked States of the Fundamental Active Photonic Dimer
Creators: name: Kominis, Yannis
name: Kovanis, Vassilios
name: Bountis, Tassos
Publisher: name: arXiv
Year: 2017
Subjects: subject: Optics (physics.optics)
subject: Chaotic Dynamics (nlin.CD)
subject: FOS: Physical sciences

description: Coupled semiconductor lasers are systems possessing complex dynamics that are interesting for numerous applications in photonics. In this work, we investigate the existence and the stability of asymmetric phase-locked states of the fundamental active photonic dimer consisting of two coupled lasers. We show that stable phase-locked states of arbitrary asymmetry exist for extended regions of the parameter space of the system and that their field amplitude ratio and phase difference can be dynamically controlled by appropriate current injection. The model includes the important role of carrier density dynamics and shows that the phase-locked state asymmetry is related to operation conditions providing, respectively, gain and loss in the two lasers.
description: 19 pages, 9 figures
Heavy-Lifting of Gauge Theories By Cosmic Inflation
Creators: name: Kumar, Soubhik
name: Sundrum, Raman
Publisher: name: arXiv
Year: 2017
Subjects: subject: High Energy Physics - Phenomenology (hep-ph)
subject: Cosmology and Nongalactic Astrophysics (astro-ph.CO)
subject: General Relativity and Quantum Cosmology (gr-qc)
subject: FOS: Physical sciences

description: Future measurements of primordial non-Gaussianity can reveal cosmologically produced particles with masses of order the inflationary Hubble scale and their interactions with the inflaton, giving us crucial insights into the structure of fundamental physics at extremely high energies. We study gauge-Higgs theories that may be accessible in this regime, carefully imposing the constraints of gauge symmetry and its (partial) Higgsing. We distinguish two types of Higgs mechanisms: (i) a standard one in which the Higgs scale is constant before and after inflation, where the particles observable in non-Gaussianities are far heavier than can be accessed by laboratory experiments, perhaps associated with gauge unification, and (ii) a "heavy-lifting" mechanism in which couplings to curvature can result in Higgs scales of order the Hubble scale during inflation while reducing to far lower scales in the current era, where they may now be accessible to collider and other laboratory experiments. In the heavy-lifting option, renormalization-group running of terrestrial measurements yield predictions for cosmological non-Gaussianities. If the heavy-lifted gauge theory suffers a hierarchy problem, such as does the Standard Model, confirming such predictions would demonstrate a striking violation of the Naturalness Principle. While observing gauge-Higgs sectors in non-Gaussianities will be challenging given the constraints of cosmic variance, we show that it may be possible with reasonable precision given favorable couplings to the inflationary dynamics.
description: 53 pages, 12 figures
Heliophysics Strategic Technology Office (HESTO)
Creators: name: Christe, Steven
name: Hakimzadeh, Roshanak
name: McAllen, Kyle
name: Cold, Melissa
Publisher: name: Zenodo
Year: 2023

description: In response to the Decadal Survey and the 2019 Congressional mandate, the NASA Heliophysics Division (HDP) established a new Technology Program. In order to manage this new program, HPD has created the Heliophysics Strategic Technology Office (HESTO) whose goal is to enable novel and transformative new capabilities and mission concepts in Heliophysics by expanding the limits of what is measurable, observable, and achievable. HESTO partners with researchers and scientists to help solve technological challenges inherent in space-based observations to better understand our heliosphere and the dynamic, interrelated systems contained within it. Through an open and competitive solicitation process, the HPD Technology program provide grants to universities, corporations, NASA Centers, and other institutions to explore new instrument designs and technologies. HESTO’s purpose is to (1) oversee and support the Heliophysics technology portfolio from early development, maturation, and eventual infusion, (2) engage with and expand the Heliophysics technology community, (3) identify technology gaps and trends to guide future investments and, (3) support the HPD in implementing the Technology Program. This presentation will introduce HESTO to the community and what it can do for you.
INTERNAL CONTROL AND BANK PERFORMANCE: EVIDENCE FROM SELECTED COMMERCIAL BANKS IN NIGERIA
Creators: name: Prof. Agbo, Elias Igwebuike
name: Basilia Chiamaka, Nwachukwu Ph.D.
Publisher: name: ZAP JOURNALS
Year: 2025
Subjects: Internal control system; Bank performance, COSO; Nigeria.

description: Despite the crucial role played by the banking sector in regulating the economy worldwide and the significant failures and crises it has experienced in the past for which t weakness in internal control was responsible, a majority of the studies concerning the connection between internal control and firm performance were carried out employing members from numerous sectors other than the sector. This research examines the effect of the compliance with internal control system on the performance of banks in Nigeria Using the survey research approach, the extent the compliance with internal control system has affected the indicators of performance in banks was examined, Frequency tables and percentages were employed to collate and arrange the views those that responded to the questionnaires distributed. The hypotheses of the study were tested using one sample-test technique. The research had a population of 84, while the size of the sample was 69. The results indicate that internal control system has a strong and positive impact on the performance of deposit-money banks in Nigeria. This suggests that bank management should entrench significant internal control components in their banks to achieve optimal performance
MOESM1 of POLE mutations improve the prognosis of endometrial cancer via regulating cellular metabolism through AMF/AMFR signal transduction
Creators: name: Li, Yiran
name: Bian, Yiding
name: Wang, Kai
name: Wan, Xiao-Ping
Publisher: name: figshare
Year: 2019
Subjects: subject: Medicine
subject: Microbiology
subject: FOS: Biological sciences
subject: Genetics
subject: Molecular Biology
subject: Biological Sciences not elsewhere classified
subject: Mathematical Sciences not elsewhere classified
subject: Infectious Diseases
subject: FOS: Health sciences

description: Additional file 1: Table S1. The number of mutation classification and type in 530 endometrial cancer patients. Table S2. The mutation frequency of top 124 mutated genes in 530 endometrial cancer patients. Table S3. The relationship between POLE mutations and four clinical characteristics by chi-square test. Figure S1. SNP and mutation istatistics in 530 endometrial cancer patients. Figure S2. Kaplan-Meier curve and Log-rank test for endometrial cancer patients based on POLE mutational status classification when excluded hypermutated phenotypes (more than 500 mutations per sample), N = 387. Figure S3. (A-B) GSEA of genes between mutant and wild type POLE endometrial cancer samples. Figure S4. (A) Kaplan-Meier curve and Log-rank test for endometrial cancer patients based on expression level of AMF/GPI classification. (B) Kaplan-Meier curve and Log-rank test for endometrial cancer patients based on expression level of AMFR/gp78 classification.
Physical parameters and emission mechanism in Gamma-Ray Bursts
Creators: name: Derishev, E. V.
name: Kocharovsky, V. V.
name: Kocharovsky, Vl. V.
Publisher: name: arXiv
Year: 2000
Subjects: subject: Astrophysics (astro-ph)
subject: FOS: Physical sciences

description: Detailed information on the physical parameters in the sources of cosmological Gamma-Ray Bursts (GRBs) is obtained from few plausible assumptions consistent with observations. Model-independent requirements posed by these assumptions on the emission mechanism in GRBs are formulated. It is found that the observed radiation in sub-MeV energy range is generated by the synchrotron emission mechanism, though about ten per cent of the total GRB energy should be converted via the inverse Compton process into ultra-hard spectral domain (above 100 GeV). We estimate the magnetic field strength in the emitting region, the Lorentz factor of accelerated electrons, and the typical energy of IC photons. We show that there is a "line-of-death" relation for GRBs and derive from this relation the lower limits on both GRB duration and GRB variability timescale. The upper limit on the Lorentz factor of GRB fireballs is also found. We demonstrate that steady-state electron distribution consistent with the Compton losses may produce different spectral indices, e.g., 3/4 as opposed to the figure 1/2 widely discussed in the literature. It is suggested that the changes in the decline rate observed in the lightcurves of several GRB afterglows may be due to the time evolution of spectral break, which appears in the synchrotron emission generated by steady-state self-consistent electron distribution.
description: Journal reference added, introduction extended, minor changes in notations
Bidisperse and polydisperse suspension rheology at large solid fraction
Creators: name: Pednekar, Sidhant
name: Chun, Jaehun
name: Morris, Jeffrey
Publisher: name: arXiv
Year: 2017
Subjects: subject: Soft Condensed Matter (cond-mat.soft)
subject: FOS: Physical sciences

description: At the same solid volume fraction, bidisperse and polydisperse suspensions display lower viscosities, and weaker normal stress response, compared to monodisperse suspensions. The reduction of viscosity associated with size distribution can be explained by an increase of the maximum flowable, or jamming, solid fraction $ϕ_m$. In this work, dense suspensions are simulated under strong shearing, where thermal motion and repulsive forces are negligible, but we allow for particle contact with a mild frictional interaction with interparticle friction coefficient of $μ = 0.2$. Aspects of bidisperse suspension rheology are first revisited to establish that the approach reproduces established trends; the study of bidisperse suspensions at size ratios of large to small particle radii of $δ= 2$ to 4 shows that a minimum in the viscosity occurs for $ζ$ slightly above 0.5, where $ζ= ϕ_l/ϕ$ is the fraction of the total solid volume occupied by the large particles. The simple shear flows of polydisperse suspensions with truncated normal and log normal size distributions, and bidisperse suspensions which are statistically equivalent with these polydisperse cases up to third moment of the size distribution, are simulated and the rheologies are extracted. Prior work shows that such distributions with equivalent low-order moments have similar $ϕ_m$, and the rheological behaviors of normal, log normal and bidisperse cases are shown to be in close agreement for a wide range of standard deviation in particle size, with standard correlations which are functionally dependent on $ϕ/ϕ_m$ providing excellent agreement with the rheology found in simulation. The close agreement of both viscosity and normal stress response between bi- and polydisperse suspensions demonstrates the controlling influence of the maximum packing fraction in noncolloidal suspensions
Wavefront-sensing with a thin diffuser
Creators: name: Berto, Pascal
name: Rigneault, Hervé
name: Guillon, Marc
Publisher: name: arXiv
Year: 2017
Subjects: subject: Optics (physics.optics)
subject: FOS: Physical sciences

description: We propose and implement a broadband, compact, and low-cost wavefront sensing scheme by simply placing a thin diffuser in the close vicinity of a camera. The local wavefront gradient is determined from the local translation of the speckle pattern. The translation vector map is computed thanks to a fast diffeomorphic image registration algorithm and integrated to reconstruct the wavefront profile. The simple translation of speckle grains under local wavefront tip/tilt is ensured by the so-called "memory effect" of the diffuser. Quantitative wavefront measurements are experimentally demonstrated both for the few first Zernike polynomials and for phase-imaging applications requiring high resolution. We finally provided a theoretical description of the resolution limit that is supported experimentally.
The Hydration Number of Li+ in Liquid Water
Creators: name: Rempe, Susan B.
name: Pratt, Lawrence R.
name: Hummer, Gerhard
name: Kress, Joel D.
name: Martin, Richard L.
name: Redondo, Antonio
Publisher: name: arXiv
Year: 2000
Subjects: subject: Chemical Physics (physics.chem-ph)
subject: Biological Physics (physics.bio-ph)
subject: FOS: Physical sciences

description: A theoretical treatment based upon the quasi-chemical theory of solutions predicts the most probable number of water neighbors in the inner shell of a Li+ ion in liquid water to be four. The instability of a six water molecule inner sphere complex relative to four-coordinated structures is confirmed by an `ab initio' molecular dynamics calculation. A classical Monte Carlo simulation equilibrated 26 water molecules with a rigid six-coordinated Li(H2O)6+ complex with periodic boundary conditions in aqueous solution. With that initial configuration for the molecular dynamics, the six-coordinated structure relaxed into four-coordinated arrangements within 112 fs and stabilized. This conclusion differs from prior interpretations of neutron and X-ray scattering results on aqueous solutions.
description: 9 pages, 2 figures
Methods for preliminary study in 2021 from Experimental evidence supports the ability of spotted lanternfly to hitchhike on vehicle exteriors as a mechanism for anthropogenic dispersal
Creators: name: Elsensohn, Johanna
name: Wolford, Scott
name: Tabb, Amy
name: Leskey, Tracy
Publisher: name: The Royal Society
Year: 2024
Subjects: classificationCode: 310399
subject: Ecology not elsewhere classified

description: Supplementary File 1. Methods and results of the preliminary assays conducted in Fall 2021 during the development of the experimental methods for this manuscript.
An Age-Structured Single-State Drug Initiation Model: Cycles of Drug Epidemics and Optimal Prevention Programs
Creators: name: Almeder, Christian
name: Caulkins, Jonathan P.
name: Feichtinger, Gustav
name: Tragler, Gernot
Publisher: name: Carnegie Mellon University
Year: 2002
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences
subject: 160510 Public Policy
subject: FOS: Political science

description: This paper introduces a model for drug initiation that extends traditional dynamic models by considering explicitly the age distribution of the users. On the basis of a 2-groups model in which the population is split up in an user and a non-user group the advantage of a continuous age distribution is shown by considering more details and by yielding new results. Neglecting death rates allows to reduce the model to a single state (1-group) descriptive model which is capable to simulate the complex behavior of drug epidemics. Furthermore, prevention programs – especially school-based programs – can be targeted to certain age classes. So in order to discover how best to allocate resources to prevention programs over different age classes we formulate and solve also optimal control models.
title: évidence 3 annotation
Creators: name: Mạc, Đăng Khoa
Publisher: name: COCOON - https://cocoon.huma-num.fr (Huma-Num - CNRS)
publisherIdentifier: https://ror.org/04ces3204
publisherIdentifierScheme: ROR
Year: 2015
Subjects: subject: Vietnamien
subject: vie

description: Conforms to: Praat textgrid
Effects of carbon sources on production and properties of curdlan using Agrobaterium sp. DH-2
Creators: name: Wan, Jie
name: Wang, Yifeng
name: Jiang, Deming
name: Gao, Hongliang
name: Yang, Guang
name: Yang, Xuexia
Publisher: name: Taylor & Francis
Year: 2020
Subjects: subject: Biochemistry
subject: Space Science
subject: Physical Sciences not elsewhere classified
subject: Microbiology
subject: FOS: Biological sciences
subject: Biotechnology
subject: Chemical Sciences not elsewhere classified
subject: Ecology
subject: Biological Sciences not elsewhere classified
subject: Inorganic Chemistry
subject: FOS: Chemical sciences

description: Curdlan has wide potential application in the food and biomedical fields due to its unique thermal gel and biological activity. This study investigated the effect of six sugars including glucose, fructose, lactose, maltose, sucrose and xylose as carbon sources on production and properties of curdlan using Agrobacterium sp. DH-2. The maximum production (38.1 g/L and 37.4 g/L, respectively) and yield (0.58 g curdlan/g sucrose and 0.53 g curdlan/g maltose, respectively) of curdlan were achieved by sucrose and maltose, followed by glucose, fructose, lactose and xylose. Scanning electron micrographs showed that the surface of cells was smooth in strain growth phase, while cells were covered by curdlan matrix acted as a net in the curdlan synthesis phase. The highest glucosyltransferase activity (19.9 U/g biomass) corresponded to the maximum curdlan production using the sucrose medium. The molecular weight and gel strength of curdlan were influenced by the carbon sources. The curdlan from xylose medium resulted in a maximum molecular weight of 1.59 × 106 Da and the highest gel strength of 989.2 g/cm2, while the curdlan from sucrose medium resulted in a lowest molecular weight of 1.10 × 106 Da and gel strength of 672.8 g/cm2. The high molecular weight of curdlan had high gel strength.
All Reviews are Not Created Equal: The Disaggregate Impact of Reviews and Reviewers at Amazon.com
Creators: name: Chen, Pei-Yu
name: Dhanasobhon, Samita
name: Smith, Michael
Publisher: name: Carnegie Mellon University
Year: 2001
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences
subject: 160510 Public Policy
subject: FOS: Political science

description: Online product review networks help to transmit information that customers can use to evaluate product quality. The prior literature has found that, in the aggregate, better product reviews lead to higher sales. However, product review networks increasingly include an explicit social component that allows consumers to evaluate individual reviews based on the status of the reviewer and on the "helpfulness" of the review to the community. In this research, we extend this literature by analyzing the impact of reviews at a disaggregate level. We find that reviews that the community finds helpful have a stronger influence on consumers' purchase decisions than other reviews do. Moreover, these reviews have a stronger impact on less popular books than on more popular books, where consumers may be able to use other outside information sources to form an opinion of the product. Overall, our results suggest that the micro-level dynamics of community interactions are valuable in signaling quality over-and-above aggregate-level scores. One implication of this result is that the micro-level dynamics of reputation communities make it harder for self-interested parties to manipulate reviews versus an environment where consumers only have aggregate quality measures.
Performance of a spin-based insulated gate field effect transistor
Creators: name: Hall, Kimberley C.
name: Flatté, Michael E.
Publisher: name: arXiv
Year: 2006
Subjects: subject: Mesoscale and Nanoscale Physics (cond-mat.mes-hall)
subject: Materials Science (cond-mat.mtrl-sci)
subject: FOS: Physical sciences

description: Fundamental physical properties limiting the performance of spin field effect transistors are compared to those of ordinary (charge-based) field effect transistors. Instead of raising and lowering a barrier to current flow these spin transistors use static spin-selective barriers and gate control of spin relaxation. The different origins of transistor action lead to distinct size dependences of the power dissipation in these transistors and permit sufficiently small spin-based transistors to surpass the performance of charge-based transistors at room temperature or above. This includes lower threshold voltages, smaller gate capacitances, reduced gate switching energies and smaller source-drain leakage currents.
description: 4 pages including 3 figures, APL in press
СУВ РЕСУРСЛАРИ  СУВЛAРИДAГИ КИМЁВИЙ МОДДAЛAР УЧУН РУХСАТ ЭТИЛГАН МИҚДОРЛAРНИ ИШЛАБ ЧИҚИШ МЕТОДОЛОГИЯСИ
Creators: name: Искандарова, Ш.Т.
name: Усманов, И.A.
name: Хасанова, М.И.
Publisher: name: Zenodo
Year: 2024

description: Ушбу мақола мавжуд минтақавий хусусиятлар ва жаҳон соғлиқни сақлаш ташкилотининг талабларини ҳисобга олган ҳолда сув ҳавзалари сувларидаги зарарли моддаларни гигиеник регламентлаш бўйича экспериментал тадқиқотларни ягона тартибга келтиришга бағишланган. Сув ҳавзаларида зарарли кимёвий моддаларнинг рухсат этилган максимал концентрациясини (РЭК) ишлаб чиқиш методологияси ўткир, ўткир ости ва сурункали санитария-токсикологик тажрибалар шароитида ҳар хил турдаги экспериментал ҳайвонларда бир қатор экспериментал тадқиқотлар ўтказишни ўз ичига олади.
A Characterization of Mobility Management in User-centric Networks
Creators: name: Nascimento, Andrea
name: Sofia, Rute
name: Condeixa, Tiago
name: Sargento, Susana
Publisher: name: arXiv
Year: 2017
Subjects: subject: Networking and Internet Architecture (cs.NI)
subject: FOS: Computer and information sciences

description: Mobility management is a key aspect to consider in future Internet architectures, as these architectures include a highly nomadic end-user which often relies on services provided by multi-access networks. In contrast, today's mobility management solutions were designed having in mind simpler scenarios and requirements from the network and where roaming could often be taken care of with previously established agreements. With a more dynamic behavior in the network, and also with a more prominent role from the end-user, mobility management has to deal with additional requirements derived from new Internet paradigms. To assist in understanding such requirements and also how to deal with them, this paper proposes a starting point to dismantle current mobility management notions. Our contribution is an initial proposal on defining mobility management in concrete functional blocks, their interaction, as well as a potential grouping which later can assist in deriving novel and more flexible mobility management architectures.
description: New2AN 2011
Air Pollution, Power Grid, and Infant Health: Evidence from the Shutdown of TVA Nuclear Power Plants in the 1980s
Creators: name: Severnini, Edson
Publisher: name: Carnegie Mellon University
Year: 2014
Subjects: subject: Information Systems
subject: FOS: Computer and information sciences
subject: 160510 Public Policy
subject: FOS: Political science

description: When environmental regulations focus on a subset of power plants, the ultimate goal of human health protection may not be reached. Because power plants are interconnected through the electrical grid, excessive scrutiny of a group of facilities may generate more pollution out of another group, with potential deleterious effects to public health. I study the impact of the shutdown of nuclear power plants in the Tennessee Valley Authority (TVA) in the 1980s, on health outcomes at birth. After the Three Mile Island accident in 1979, the Nuclear Regulatory Commission (NRC) intensifies inspections in nuclear facilities leading to the shutdown of many of them, including Browns Ferry and Sequoyah in the TVA area. I first show that, in response to the shutdown, electricity generation shifts one-to-one to coal-fired power plants within TVA, increasing air pollution in counties where they are located. Second, I find that babies born after the shutdown have both lower birth weight and lower gestational age in the counties most affected by the shutdown. Third, I highlight the presence of substantial heterogeneity in those effects depending on how much more electricity those coal-powered facilities are generating in response to the shutdown. Lastly, I use the heterogeneity in response to the shutdown to provide suggestive evidence on the "safe" threshold of exposure to total suspended particles (TSP), which may help the Environmental Protection Agency (EPA) to set the National Ambient Air Quality Standards (NAAQS) for particulate matters (PM). It may also help regulators to incentivize power companies to respond optimally to unexpected energy shortages.